LOCUS 026_IIG_Bs27_003_SNP 3665329 bp DNA circular UNA 12-JAN-2021 DEFINITION Bacillus subtilis strain Delta6 (hybrid trycycler assembly). ACCESSION urn.local...1dz-cvskbte VERSION urn.local...1dz-cvskbte KEYWORDS . SOURCE ORGANISM . FEATURES Location/Qualifiers S_feature complement(3665219..658) /Source="Nicolas_S_feature" /locus_tag="new_299_1067_c" /HighExp="S4, LoTm, S3, C30, S5, S7, S6, T5.0H, S8, M9-stat" /AntisenseName="dnaA" /AntisenseCor="-0.57810076860528403" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S4" CDS 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2167836, 2846289, 12682299, 16120674, 1779750, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2167836, 2846289, 12682299, 16120674, 1779750, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosomal replication initiator informational ATPase" /protein_id="NP_387882.1" /db_xref="EnsemblGenomes-Gn:BSU00010" /db_xref="EnsemblGenomes-Tr:CAB11777" /db_xref="GOA:P05648" /db_xref="InterPro:IPR001957" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013159" /db_xref="InterPro:IPR013317" /db_xref="InterPro:IPR018312" /db_xref="InterPro:IPR020591" /db_xref="InterPro:IPR024633" /db_xref="InterPro:IPR027417" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG10065" /db_xref="UniProtKB/Swiss-Prot:P05648" /translation="MENILDLWNQALAQIEKKLSKPSFETWMKSTKAHSLQGDTLTIT APNEFARDWLESRYLHLIADTIYELTGEELSIKFVIPQNQDVEDFMPKPQVKKAVKED TSDFPQNMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHL MHAIGHYVIDHNPSAKVVYLSSEKFTNEFINSIRDNKAVDFRNRYRNVDVLLIDDIQF LAGKEQTQEEFFHTFNTLHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPP DLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDIN ADLAAEALKDIIPSSKPKVITIKEIQRVVGQQFNIKLEDFKAKKRTKSVAFPRQIAMY LSREMTDSSLPKIGEEFGGRDHTTVIHAHEKISKLLADDEQLQQHVKEIKEQLK*" /label="dnaA CDS" gene 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /label="dnaA gene" promotor_-10 complement(631..649) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(657) /Source="Nicolas_upshifts" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(665..670) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1342..1529 /Source="Nicolas_S_feature" /locus_tag="new_1751_1938" /HighExp="G150, Heat, G180, G135, Paraq, Oxctl, dia0, LBGstat, S1, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S5" CDS 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2846289, 11395445, 12682299, 20453097, 23228104, 28878042" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846289, 11395445, 12682299, 20453097, 23228104, 28878042; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (beta subunit)" /protein_id="NP_387883.1" /db_xref="EnsemblGenomes-Gn:BSU00020" /db_xref="EnsemblGenomes-Tr:CAB11778" /db_xref="GOA:P05649" /db_xref="InterPro:IPR001001" /db_xref="InterPro:IPR022634" /db_xref="InterPro:IPR022635" /db_xref="InterPro:IPR022637" /db_xref="PDB:4TR6" /db_xref="SubtiList:BG10066" /db_xref="UniProtKB/Swiss-Prot:P05649" /translation="MKFTIQKDRLVESVQDVLKAVSSRTTIPILTGIKIVASDDGVSF TGSDSDISIESFIPKEEGDKEIVTIEQPGSIVLQARFFSEIVKKLPMATVEIEVQNQY LTIIRSGKAEFNLNGLDADEYPHLPQIEEHHAIQIPTDLLKNLIRQTVFAVSTSETRP ILTGVNWKVEQSELLCTATDSHRLALRKAKLDIPEDRSYNVVIPGKSLTELSKILDDN QELVDIVITETQVLFKAKNVLFFSRLLDGNYPDTTSLIPQDSKTEIIVNTKEFLQAID RASLLAREGRNNVVKLSAKPAESIEISSNSPEIGKVVEAIVADQIEGEELNISFSPKY MLDALKVLEGAEIRVSFTGAMRPFLIRTPNDETIVQLILPVRTY*" /label="dnaN CDS" gene 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /label="dnaN gene" downshifts 2650 /Source="Nicolas_upshifts" /id="D1" /incds=0 /nref=29 /ntot=161 /MaxReadThrough="5.22584" /MaxDrop="4.17087" /score="21.887269" /energy="-14.2" /TU="U1" /idTUdmin="U1" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" promotor_-35 2731..2735 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2752..2771 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2760 /Source="Nicolas_upshifts" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24637032, 24939895" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24637032, 24939895; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA binding protein involved in ribosome maturation" /protein_id="NP_387884.1" /db_xref="EnsemblGenomes-Gn:BSU00030" /db_xref="EnsemblGenomes-Tr:CAB11779" /db_xref="GOA:P05650" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014330" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10067" /db_xref="UniProtKB/Swiss-Prot:P05650" /translation="MANPISIDTEMITLGQFLKLADVIQSGGMAKWFLSEHEVLVNDE PDNRRGRKLYVGDVVEIEGFGSFQVVN*" /label="rlbA CDS" gene 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /label="rlbA gene" CDS 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 16061691, 16385024, 22342069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 16061691, 16385024, 22342069; Product type f: factor" /codon_start=1 /transl_table=11 /product="RecA filament-DNA complex stabilisation, ssDNA and dsDNA binding, ATP binding" /protein_id="NP_387885.1" /db_xref="EnsemblGenomes-Gn:BSU00040" /db_xref="EnsemblGenomes-Tr:CAB11780" /db_xref="GOA:P05651" /db_xref="InterPro:IPR001238" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR018078" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10068" /db_xref="UniProtKB/Swiss-Prot:P05651" /translation="MYIQNLELTSYRNYDHAELQFENKVNVIIGENAQGKTNLMEAIY VLSMAKSHRTSNDKELIRWDKDYAKIEGRVMKQNGAIPMQLVISKKGKKGKVNHIEQQ KLSQYVGALNTIMFAPEDLNLVKGSPQVRRRFLDMEIGQVSPVYLHDLSLYQKILSQR NHFLKQLQTRKQTDRTMLDVLTDQLVEVAAKVVVKRLQFTAQLEKWAQPIHAGISRGL EELTLKYHTALDVSDPLDLSKIGDSYQEAFSKLREKEIERGVTLSGPHRDDVLFYVNG RDVQTYGSQGQQRTTALSLKLAEIDLIHEEIGEYPILLLDDVLSELDDYRQSHLLHTI QGRVQTFVTTTSVDGIDHETLRQAGMFRVQNGALVK*" /label="recF CDS" gene 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /label="recF gene" misc_feature 3226..3245 /Source="Nicolas_upshift_promotors" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3244 /Source="Nicolas_upshifts" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of extracellular matrix formation" /protein_id="NP_387886.2" /db_xref="EnsemblGenomes-Gn:BSU00050" /db_xref="EnsemblGenomes-Tr:CAB11781" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG10069" /db_xref="UniProtKB/Swiss-Prot:P37525" /translation="MYIHLGDDFVVSTRDIVGIFDFKANMSPIVEEFLKKQKHKVVPS VNGTPKSIVVTVQNIYYSPLSSSTLKKRAQFMFEIDS*" /label="remB CDS" gene 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /label="remB gene" CDS 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit B)" /protein_id="NP_387887.1" /db_xref="EnsemblGenomes-Gn:BSU00060" /db_xref="EnsemblGenomes-Tr:CAB11782" /db_xref="GOA:P05652" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR011557" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR034160" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10070" /db_xref="UniProtKB/Swiss-Prot:P05652" /translation="MEQQQNSYDENQIQVLEGLEAVRKRPGMYIGSTNSKGLHHLVWE IVDNSIDEALAGYCTDINIQIEKDNSITVVDNGRGIPVGIHEKMGRPAVEVIMTVLHA GGKFDGSGYKVSGGLHGVGASVVNALSTELDVTVHRDGKIHRQTYKRGVPVTDLEIIG ETDHTGTTTHFVPDPEIFSETTEYDYDLLANRVRELAFLTKGVNITIEDKREGQERKN EYHYEGGIKSYVEYLNRSKEVVHEEPIYIEGEKDGITVEVALQYNDSYTSNIYSFTNN INTYEGGTHEAGFKTGLTRVINDYARKKGLIKENDPNLSGDDVREGLTAIISIKHPDP QFEGQTKTKLGNSEARTITDTLFSTAMETFMLENPDAAKKIVDKGLMAARARMAAKKA RELTRRKSALEISNLPGKLADCSSKDPSISELYIVEGDSAGGSAKQGRDRHFQAILPL RGKILNVEKARLDKILSNNEVRSMITALGTGIGEDFNLEKARYHKVVIMTDADVDGAH IRTLLLTFFYRYMRQIIENGYVYIAQPPLYKVQQGKRVEYAYNDKELEELLKTLPQTP KPGLQRYKGLGEMNATQLWETTMDPSSRTLLQVTLEDAMDADETFEMLMGDKVEPRRN FIEANARYVKNLDI*" /label="gyrB CDS" gene 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /label="gyrB gene" promotor_-10 complement(6003..6021) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(6005) /Source="Nicolas_upshifts" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(6037..6042) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 6375..6584 /Source="Nicolas_S_feature" /locus_tag="new_6784_6993" /HighExp="Cold, H2O2, G180, Oxctl, G135, G150, Sw, dia15, LBGexp, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S6" CDS 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /EC_number="5.99.1.3" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901, 27557712" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901, 27557712; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit A)" /protein_id="NP_387888.1" /db_xref="EnsemblGenomes-Gn:BSU00070" /db_xref="EnsemblGenomes-Tr:CAB11783" /db_xref="GOA:P05653" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005743" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="PDB:4DDQ" /db_xref="SubtiList:BG10071" /db_xref="UniProtKB/Swiss-Prot:P05653" /translation="MSEQNTPQVREINISQEMRTSFLDYAMSVIVSRALPDVRDGLKP VHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYM LVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVM PSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEVIPGPDF PTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEK IADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL LALVDGQPKVLTLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGLRVALDHLDA VISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKL IAELKDILANEYKVLEIIREELTEIKERFNDERRTEIVTSGLETIEDEDLIERENIVV TLTHNGYVKRLPASTYRSQKRGGKGVQGMGTNEDDFVEHLISTSTHDTILFFSNKGKV YRAKGYEIPEYGRTAKGIPIINLLEVEKGEWINAIIPVTEFNAELYLFFTTKHGVSKR TSLSQFANIRNNGLIALSLREDDELMGVRLTDGTKQIIIGTKNGLLIRFPETDVREMG RTAAGVKGITLTDDDVVVGMEILEEESHVLIVTEKGYGKRTPAEEYRTQSRGGKGLKT AKITENNGQLVAVKATKGEEDLMIITASGVLIRMDINDISITGRVTQGVRLIRMAEEE HVATVALVEKNEEDENEEEQEEV*" /label="gyrA CDS" gene 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /label="gyrA gene" promotor_-35 8964..8967 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 8965 /Source="Nicolas_upshifts" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 8984..9001 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 9031 /Source="Nicolas_upshifts" /id="D2" /incds=0 /nref=251 /ntot=261 /MaxReadThrough="3.73971" /MaxDrop="8.1288" /score="33.5021066" /energy="-14.1" /TU="NA" /idTUdmin="U4" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 9095..9101 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 9115..9134 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 9120..9205 /Source="Nicolas_S_feature" /locus_tag="new_9529_9614" /HighExp="LBGstat, H2O2, Paraq, Oxctl, UNK1, LBGexp, LPhT, MG-0.2, MG 25, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S7" upshifts 9120 /Source="Nicolas_upshifts" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 9191..9198 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 9207 /Source="Nicolas_upshifts" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 9213..9232 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" rRNA 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-16S rRNA" gene 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /label="rrnO-16S gene" tRNA 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ile tRNA" gene 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /label="trnO-Ile gene" tRNA 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ala tRNA" gene 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /label="trnO-Ala gene" rRNA 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-23S rRNA" gene 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /label="rrnO-23S gene" rRNA 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-5S rRNA" gene 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /label="rrnO-5S gene" S_feature 14402..15459 /Source="Nicolas_S_feature" /locus_tag="new_14811_15868" /HighExp="G180, T0.0H, T0.30H, G135, T-0.40H, LBGstat, Cold, Paraq, C30, Oxctl" /AntisenseName="yaaC" /AntisenseCor="-4.5985764709218099E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S8" CDS complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387889.1" /db_xref="EnsemblGenomes-Gn:BSU00080" /db_xref="EnsemblGenomes-Tr:CAB11784" /db_xref="InterPro:IPR026988" /db_xref="SubtiList:BG10072" /db_xref="UniProtKB/Swiss-Prot:P37526" /translation="MTYHEWKDLALFYSVESTQKFLEKVYILNGINDAKKNSFKNSER FIYFLKHAESFYKQAAYSPLEIKPILLFYGMAQLIKACLITRDPHYPSHTSVLAHGVT TRKRKKQNYCFSDDEVKIQRNGLCVHFMKHLFGQSDIVDERYTMKKLLMAIPELSDIF YFQQKERFMTKVEKDKNEIFVPEEVVINYKMSDSRFAEYMSHHYQWSFTKKNEHGLLF EISPQDKEPWTSTSLLFDMEKNQYYIPSQREQFLRLPEMTIHYLILYNVGMIARYETE WWYELLTQHISDDYVLIQQFLLVSEKKFPKYASQFLLHF*" /label="yaaC CDS" gene complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /label="yaaC gene" promotor_-35 15438..15445 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 15460..15479 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 15461 /Source="Nicolas_upshifts" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(15466) /Source="Nicolas_upshifts" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(15475..15486) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(15500..15506) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /EC_number="1.1.1.205" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1722815, 17611193, 1979163, 3125411, 8917437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1722815, 17611193, 1979163, 3125411, 8917437; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inosine-monophosphate dehydrogenase" /protein_id="NP_387890.1" /db_xref="EnsemblGenomes-Gn:BSU00090" /db_xref="EnsemblGenomes-Tr:CAB11785" /db_xref="GOA:P21879" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005990" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG10073" /db_xref="UniProtKB/Swiss-Prot:P21879" /translation="MWESKFSKEGLTFDDVLLVPAKSEVLPRDVDLSVELTKTLKLNI PVISAGMDTVTESAMAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITNPFFL TPDHQVFDAEHLMGKYRISGVPIVNNEEDQKLVGIITNRDLRFISDYSMKISDVMTKE ELVTASVGTTLDEAEKILQKHKIEKLPLVDDQNKLKGLITIKDIEKVIEFPNSSKDIH GRLIVGAAVGVTGDTMTRVKKLVEANVDVIVIDTAHGHSQGVLNTVTKIRETYPELNI IAGNVATAEATRALIEAGADVVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKH GKTIIADGGIKFSGDITKALAAGGHAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMG SVAAMEKGSKDRYFQEENKKFVPEGIEGRTPYKGPVEETVYQLVGGLRSGMGYCGSKD LRALREEAQFIRMTGAGLRESHPHDVQITKESPNYTIS*" /label="guaB CDS" gene 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /label="guaB gene" downshifts complement(15510) /Source="Nicolas_upshifts" /id="D3" /incds=0 /nref=33 /ntot=102 /MaxReadThrough="1.81989" /MaxDrop="4.44626" /score="-6.76739893" /energy="-12.2" /TU="NA" /idTUdmin="U12" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(15536..15636) /Source="Nicolas_upshift_promotors" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(15576) /Source="Nicolas_upshifts" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(16829..17424) /Source="Nicolas_S_feature" /locus_tag="new_17238_17833_c" /HighExp="Etha, Gly, C30, Salt, S8, S6, HiTm, S7, Sw, C90" /AntisenseName="dacA" /AntisenseCor="-0.39306815699287101" /AntisenseRegPval="-10.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S9" downshifts 16960 /Source="Nicolas_upshifts" /id="D4" /incds=0 /nref=243 /ntot=277 /MaxReadThrough="3.34899" /MaxDrop="7.78161" /score="26.7620012" /energy="-10.6" /TU="NA" /idTUdmin="U10" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 17018..17022 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 17038..17057 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 17044..17124 /Source="Nicolas_S_feature" /locus_tag="new_17453_17533" /HighExp="C30, LBGstat, G180, G150, LBGexp, G135, Lbexp, Oxctl, dia0, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S10" upshifts 17044 /Source="Nicolas_upshifts" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /EC_number="3.4.16.4" /experiment="publication(s) with functional evidences, PMID:8370539, 9864321, 10383963, 21378199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8370539, 9864321, 10383963, 21378199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5)" /protein_id="NP_387891.1" /db_xref="EnsemblGenomes-Gn:BSU00100" /db_xref="EnsemblGenomes-Tr:CAB11786" /db_xref="GOA:P08750" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10074" /db_xref="UniProtKB/Swiss-Prot:P08750" /translation="MNIKKCKQLLMSLVVLTLAVTCLAPMSKAKAASDPIDINASAAI MIEASSGKILYSKNADKRLPIASMTKMMTEYLLLEAIDQGKVKWDQTYTPDDYVYEIS QDNSLSNVPLRKDGKYTVKELYQATAIYSANAAAIAIAEIVAGSETKFVEKMNAKAKE LGLTDYKFVNATGLENKDLHGHQPEGTSVNEESEVSAKDMAVLADHLITDYPEILETS SIAKTKFREGTDDEMDMPNWNFMLKGLVSEYKKATVDGLKTGSTDSAGSCFTGTAERN GMRVITVVLNAKGNLHTGRFDETKKMFDYAFDNFSMKEIYAEGDQVKGHKTISVDKGK EKEVGIVTNKAFSLPVKNGEEKNYKAKVTLNKDNLTAPVKKGTKVGKLTAEYTGDEKD YGFLNSDLAGVDLVTKENVEKANWFVLTMRSIGGFFAGIWGSIVDTVTGWF*" /label="dacA CDS" gene 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /label="dacA gene" promotor_-10 complement(17413..17431) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(17424) /Source="Nicolas_upshifts" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(17446..17452) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 18338 /Source="Nicolas_upshifts" /id="D5" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="6.76335" /MaxDrop="2.1925" /score="26.7620012" /energy="-10.6" /TU="U13" /idTUdmin="U10" /TUdmin=1364 /isTUend="FALSE" /label="downshifts" S_feature 18457..18565 /Source="Nicolas_S_feature" /locus_tag="new_18866_18974" /HighExp="C30, MG 15, MG 10, MG-0.1, MG 25, BMM, ferm, Cold, MG 60, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S11" promotor_-35 18535..18538 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 18553..18572 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 18567..18652 /Source="Nicolas_S_feature" /locus_tag="new_18976_19061" /HighExp="BMM, MG 25, SMM, MG 15, UNK1, MG 10, GM 150, MG-0.1, MG 150, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S12" upshifts 18567 /Source="Nicolas_upshifts" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /EC_number="4.3.3.6" /EC_number="4.-.-.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14762015, 15771487, 15911615, 16157873, 17144654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762015, 15771487, 15911615, 16157873, 17144654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, synthase subunit" /protein_id="NP_387892.1" /db_xref="EnsemblGenomes-Gn:BSU00110" /db_xref="EnsemblGenomes-Tr:CAB11787" /db_xref="GOA:P37527" /db_xref="InterPro:IPR001852" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033755" /db_xref="PDB:2NV1" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10075" /db_xref="UniProtKB/Swiss-Prot:P37527" /translation="MAQTGTERVKRGMAEMQKGGVIMDVINAEQAKIAEEAGAVAVMA LERVPADIRAAGGVARMADPTIVEEVMNAVSIPVMAKARIGHIVEARVLEAMGVDYID ESEVLTPADEEFHLNKNEYTVPFVCGCRDLGEATRRIAEGASMLRTKGEPGTGNIVEA VRHMRKVNAQVRKVVAMSEDELMTEAKNLGAPYELLLQIKKDGKLPVVNFAAGGVATP ADAALMMQLGADGVFVGSGIFKSDNPAKFAKAIVEATTHFTDYKLIAELSKELGTAMK GIEISNLLPEQRMQERGW*" /label="pdxS CDS" gene 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /label="pdxS gene" S_feature complement(18785..19514) /Source="Nicolas_S_feature" /locus_tag="new_19194_19923_c" /HighExp="S6, S8, S7, S5, S4, C30, S3, BT, C90, Gly" /AntisenseName="pdxS" /AntisenseCor="-0.65390240445415004" /AntisenseRegPval="-33.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S13" promotor_-10 complement(19502..19520) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(19514) /Source="Nicolas_upshifts" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(19536..19541) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-35" CDS 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /EC_number="3.5.1.2" /EC_number="4.3.3.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 14762015, 15771487, 17144654, 18271580, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 14762015, 15771487, 17144654, 18271580, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, glutamine amidotransferase subunit PdxT" /protein_id="NP_387893.1" /db_xref="EnsemblGenomes-Gn:BSU00120" /db_xref="EnsemblGenomes-Tr:CAB11788" /db_xref="GOA:P37528" /db_xref="InterPro:IPR002161" /db_xref="InterPro:IPR021196" /db_xref="InterPro:IPR029062" /db_xref="PDB:1R9G" /db_xref="PDB:2NV0" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10076" /db_xref="UniProtKB/Swiss-Prot:P37528" /translation="MLTIGVLGLQGAVREHIHAIEACGAAGLVVKRPEQLNEVDGLIL PGGESTTMRRLIDTYQFMEPLREFAAQGKPMFGTCAGLIILAKEIAGSDNPHLGLLNV VVERNSFGRQVDSFEADLTIKGLDEPFTGVFIRAPHILEAGENVEVLSEHNGRIVAAK QGQFLGCSFHPELTEDHRVTQLFVEMVEEYKQKALV*" /label="pdxT CDS" gene 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /label="pdxT gene" misc_RNA 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /product="T-box riboswitch specific of serine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboS RNA" gene 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /label="tboS gene" downshifts 20379 /Source="Nicolas_upshifts" /id="D6" /incds=0 /nref=9 /ntot=80 /MaxReadThrough="7.14793" /MaxDrop="4.37654" /score="41.1243331" /energy="-23.3" /TU="U13,U15" /idTUdmin="U13" /TUdmin="-1347" /isTUend="FALSE" /label="downshifts" CDS 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /EC_number="6.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10546897, 12682299, 14732487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10546897, 12682299, 14732487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="seryl-tRNA synthetase" /protein_id="NP_387894.1" /db_xref="EnsemblGenomes-Gn:BSU00130" /db_xref="EnsemblGenomes-Tr:CAB11789" /db_xref="GOA:P37464" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002317" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR015866" /db_xref="InterPro:IPR033729" /db_xref="SubtiList:BG10077" /db_xref="UniProtKB/Swiss-Prot:P37464" /translation="MLDTKMLRANFQEIKAKLVHKGEDLTDFDKFEALDDRRRELIGK VEELKGKRNEVSQQVAVLKREKKDADHIIKEMREVGEEIKKLDEELRTVEAELDTILL SIPNIPHESVPVGETEDDNVEVRKWGEKPSFAYEPKPHWDIADELGILDFERAAKVTG SRFVFYKGLGARLERALYNFMLDLHVDEYNYTEVIPPYMVNRASMTGTGQLPKFEEDA FKIREEDYFLIPTAEVPITNMHRDEILSGDSLPINYAAFSACFRSEAGSAGRDTRGLI RQHQFNKVELVKFVKPEDSYEELEKLTNQAERVLQLLELPYRVMSMCTGDLGFTAAKK YDIEVWIPSQDTYREISSCSNFEAFQARRANIRFRREAKGKPEHVHTLNGSGLAVGRT VAAILENYQQEDGSVVIPKVLRPYMGNREVMKP*" /label="serS CDS" gene 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /label="serS gene" downshifts 21726 /Source="Nicolas_upshifts" /id="D7" /incds=0 /nref=234 /ntot=255 /MaxReadThrough="0.83411" /MaxDrop="7.38039" /score="17.6549558" /energy="-13.3" /TU="NA" /idTUdmin="U13" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 21837..21844 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 21859..21878 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 21859 /Source="Nicolas_upshifts" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="upshifts" tRNA 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(UGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Ser1 tRNA" gene 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /label="trnSL-Ser1 gene" downshifts 21998 /Source="Nicolas_upshifts" /id="D8" /incds=0 /nref=168 /ntot=196 /MaxReadThrough="5.02201" /MaxDrop="8.36635" /score="29.7083093" /energy="-12.4" /TU="U17" /idTUdmin="U13" /TUdmin=272 /isTUend="FALSE" /label="downshifts" S_feature 22043..22120 /Source="Nicolas_S_feature" /locus_tag="new_22452_22529" /HighExp="Cold, H2O2, G180, Paraq, Oxctl, C30, G150, G135, BMM, Heat" /AntisenseName="dck" /AntisenseCor="0.61769771609764101" /AntisenseRegPval="-29" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S14" CDS complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /EC_number="2.7.1.76" /EC_number="2.7.1.74" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6251049, 11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6251049, 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyadenosine/deoxycytidine kinase" /protein_id="NP_387895.1" /db_xref="EnsemblGenomes-Gn:BSU00140" /db_xref="EnsemblGenomes-Tr:CAB11790" /db_xref="GOA:P37529" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10078" /db_xref="UniProtKB/Swiss-Prot:P37529" /translation="MKEHHIPKNSIITVAGTVGVGKSTLTKTLAKRLGFKTSLEEVDH NPYLEKFYHDFERWSFHLQIYFLAERFKEQKTIFEAGGGFVQDRSIYEDTGIFAKMHA DKGTMSKVDYKTYTSLFEAMVMTPYFPHPDVLIYLEGDLENILNRIEQRGREMELQTS RSYWEEMHTRYENWISGFNACPVLKLRIEDYDLLNDENSIENIVDQIASVIHDNQKK* " /label="dck CDS" gene complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /label="dck gene" promotor_-35 22106..22112 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(22111) /Source="Nicolas_upshifts" /id="D9" /incds=0 /nref=88 /ntot=213 /MaxReadThrough="1.96668" /MaxDrop="4.49235" /score="14.5948578" /energy="-11" /TU="NA" /idTUdmin="U19" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 22122..22758 /Source="Nicolas_S_feature" /locus_tag="new_22531_23167" /HighExp="G180, G135, Cold, C30, Paraq, H2O2, Oxctl, G150, S5, S6" /AntisenseName="dck" /AntisenseCor="0.15155468296621499" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S15" upshifts 22122 /Source="Nicolas_upshifts" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 22126..22137 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /EC_number="2.7.1.113" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyguanosine kinase" /protein_id="NP_387896.1" /db_xref="EnsemblGenomes-Gn:BSU00150" /db_xref="EnsemblGenomes-Tr:CAB11791" /db_xref="GOA:P37530" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10079" /db_xref="UniProtKB/Swiss-Prot:P37530" /translation="MNTAPFIAIEGPIGAGKTTLATMLSQKFGFPMINEIVEDNPYLD KFYDNIKEWSFQLEMFFLCHRYKQLEDTSDHFLKKGQPVIADYHIYKNVIFAERTLSP HQLEKYKKIYHLLTDDLPKPNFIIYIKASLPTLLHRIEKRGRPFEKKIETSYLEQLIS DYEVAIKQLQEADPELTVLTVDGDSKDFVLNKSDFERIAAHVKELIV*" /label="dgk CDS" gene complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /label="dgk gene" promotor_-10 complement(23401..23420) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(23419) /Source="Nicolas_upshifts" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(23436..23440) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /EC_number="3.2.1.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11011148, 11737650, 12177332, 10419957, 18456807, 18835992, 19933362, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore peptidoglycan N-acetylglucosaminidase" /protein_id="NP_387897.1" /db_xref="EnsemblGenomes-Gn:BSU00160" /db_xref="EnsemblGenomes-Tr:CAB11792" /db_xref="GOA:P37531" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10080" /db_xref="UniProtKB/Swiss-Prot:P37531" /translation="MVKQGDTLSAIASQYRTTTNDITETNEIPNPDSLVVGQTIVIPI AGQFYDVKRGDTLTSIARQFNTTAAELARVNRIQLNTVLQIGFRLYIPPAPKRDIESN AYLEPRGNQVSENLQQAAREASPYLTYLGAFSFQAQRNGTLVAPPLTNLRSITESQNT TLMMIITNLENQAFSDELGRILLNDETVKRRLLNEIVENARRYGFRDIHFDFEYLRPQ DREAYNQFLREARDLFHREGLEISTALAPKTSATQQGRWYEAHDYRAHGEIVDFVVLM TYEWGYSGGPPQAVSPIGPVRDVIEYALTEMPANKIVMGQNLYGYDWTLPYTAGGTPA RAVSPQQAIVIADQNNASIQYDQTAQAPFFRYTDAENRRHEVWFEDARSIQAKFNLIK ELNLRGISYWKLGLSFPQNWLLLSDQFNVVKKTFR*" /label="sleL CDS" gene complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /label="sleL gene" downshifts complement(23496) /Source="Nicolas_upshifts" /id="D10" /incds=0 /nref=40 /ntot=61 /MaxReadThrough="1.17442" /MaxDrop="6.30997" /score="3.66560192" /energy="-8.4" /TU="NA" /idTUdmin="U20" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(24773..24791) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(24794) /Source="Nicolas_upshifts" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(24807..24812) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2521622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidase (isochorismatase family)" /protein_id="NP_387898.1" /db_xref="EnsemblGenomes-Gn:BSU00170" /db_xref="EnsemblGenomes-Tr:CAB11793" /db_xref="GOA:P37532" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG10081" /db_xref="UniProtKB/Swiss-Prot:P37532" /translation="MSKADKALLIVDMINNFEFDMGETLAKKTEKIVPHILSLKEHAR QNEWPIIYINDHYGLWQADIKNIQQECTNERSKDIITKIAPVDADYFLIKPKHSAFYE TALHTLLTELQVRHIIITGIAGNICVLFTANDAYMREYSITIPKDCIASNSDEDNEFA LTMMENVLFAEITTEEQIIEK*" /label="yaaI CDS" gene complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /label="yaaI gene" promotor_-35 25223..25227 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25242..25261 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" S_feature 25246..25442 /Source="Nicolas_S_feature" /locus_tag="new_25655_25851" /HighExp="Diami, dia5, H2O2, dia15, T0.30H, T-0.40H, HiOs, T-1.10H, Salt, T0.0H" /AntisenseName="yaaI" /AntisenseCor="9.6546810160837798E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S16" upshifts 25248 /Source="Nicolas_upshifts" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" promotor_-10 complement(25382..25400) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(25401) /Source="Nicolas_upshifts" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(25415..25421) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /EC_number="3.5.4.33" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15677468, 16014871, 16415880, 16700551, 23658230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA specific adenosine A34 deaminase" /protein_id="NP_387899.1" /db_xref="EnsemblGenomes-Gn:BSU00180" /db_xref="EnsemblGenomes-Tr:CAB11794" /db_xref="GOA:P21335" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR028883" /db_xref="SubtiList:BG10082" /db_xref="UniProtKB/Swiss-Prot:P21335" /translation="MTQDELYMKEAIKEAKKAEEKGEVPIGAVLVINGEIIARAHNLR ETEQRSIAHAEMLVIDEACKALGTWRLEGATLYVTLEPCPMCAGAVVLSRVEKVVFGA FDPKGGCSGTLMNLLQEERFNHQAEVVSGVLEEECGGMLSAFFRELRKKKKAARKNLS E*" /label="tadA CDS" gene 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /label="tadA gene" promotor_-35 25932..25938 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25952..25971 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" misc_RNA 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /product="small cytoplasmic RNA (scRNA, 4.5S RNA), signal recognition particle-like (SRP) component" /experiment="publication(s) with functional evidences, PMID:1372600, 1689715" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1372600, 1689715" /label="scr RNA" gene 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /label="scr gene" S_feature 25974..26123 /Source="Nicolas_S_feature" /locus_tag="new_26383_26532" /HighExp="T1.0H, T5.0H, T1.30H, T3.30H, T3.0H, T2.30H, T4.0H, S8, T-1.10H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S17" upshifts 25974 /Source="Nicolas_upshifts" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" S_feature 26227..26322 /Source="Nicolas_S_feature" /locus_tag="new_26636_26731" /HighExp="S8, Sw, B60, B36, T2.30H, T3.30H, T1.0H, BC, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S18" downshifts 26279 /Source="Nicolas_upshifts" /id="D11" /incds=0 /nref=273 /ntot=278 /MaxReadThrough="4.46774" /MaxDrop="8.31255" /score="23.257527" /energy="-10.3" /TU="U21,U23" /idTUdmin="U21" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 26343..26346 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 26361..26380 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 26370 /Source="Nicolas_upshifts" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III subunit tau subunit" /protein_id="NP_387900.2" /db_xref="EnsemblGenomes-Gn:BSU00190" /db_xref="EnsemblGenomes-Tr:CAB11795" /db_xref="GOA:P09122" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR012763" /db_xref="InterPro:IPR022754" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10083" /db_xref="UniProtKB/Swiss-Prot:P09122" /translation="MSYQALYRVFRPQRFEDVVGQEHITKTLQNALLQKKFSHAYLFS GPRGTGKTSAAKIFAKAVNCEHAPVDEPCNECAACKGITNGSISDVIEIDAASNNGVD EIRDIRDKVKFAPSAVTYKVYIIDEVHMLSIGAFNALLKTLEEPPEHCIFILATTEPH KIPLTIISRCQRFDFKRITSQAIVGRMNKIVDAEQLQVEEGSLEIIASAADGGMRDAL SLLDQAISFSGDILKVEDALLITGAVSQLYIGKLAKSLHDKNVSDALETLNELLQQGK DPAKLIEDMIFYFRDMLLYKTAPGLEGVLEKVKVDETFRELSEQIPAQALYEMIDILN KSHQEMKWTNHPRIFFEVAVVKICQTSHQSAADLPEVDMLMKKIQQLEQEVERLKTTG IKAAAESPKKEAPRVPKGGKSNYKAPVGRIHEILKEATRPDLDLLRNSWGKLLAHLKQ QNKVSHAALLNDSEPVAAGSAAFVLKFKYEIHCKMVAEDNNGVRTNLEQILESMLGKR MDLIGVPEAQWGKIREEFLEDHQQENEGSNEPAEEDPLIAEAKKLVGADLIEIKD*" /label="dnaX CDS" gene 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /label="dnaX gene" promotor_-35 27937..27944 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 27959..27978 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 27974 /Source="Nicolas_upshifts" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16740939, 19208644, 19594923, 20639362, 22333191, 22544270; Product type f : factor" /codon_start=1 /transl_table=11 /product="nucleoid associated protein" /protein_id="NP_387901.1" /db_xref="EnsemblGenomes-Gn:BSU00200" /db_xref="EnsemblGenomes-Tr:CAB11796" /db_xref="GOA:P24281" /db_xref="InterPro:IPR004401" /db_xref="InterPro:IPR036894" /db_xref="SubtiList:BG10084" /db_xref="UniProtKB/Swiss-Prot:P24281" /translation="MRGGMGNMQKMMKQMQKMQKDMAKAQEELAEKVVEGTAGGGMVT VKANGQKEILDVIIKEEVVDPEDIDMLQDLVLAATNEALKKVDEITNETMGQFTKGMN MPGLF*" /label="ebfC CDS" gene 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /label="ebfC gene" CDS 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12065426, 24285298, 24891441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065426, 24285298, 24891441; Product type f: factor" /codon_start=1 /transl_table=11 /product="recA filament-DNA complex stabilisation factor" /protein_id="NP_387902.1" /db_xref="EnsemblGenomes-Gn:BSU00210" /db_xref="EnsemblGenomes-Tr:CAB11797" /db_xref="GOA:P24277" /db_xref="InterPro:IPR000093" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR015967" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR023627" /db_xref="InterPro:IPR023628" /db_xref="InterPro:IPR034137" /db_xref="SubtiList:BG10085" /db_xref="UniProtKB/Swiss-Prot:P24277" /translation="MQYPEPISKLIDSFMKLPGIGPKTAVRLAFFVLGMKEDVVLDFA KALVNAKRNLTYCSVCGHITDQDPCYICEDTRRDKSVICVVQDPKDVIAMEKMKEYNG QYHVLHGAISPMDGIGPEDIKIPELLKRLQDDQVTEVILATNPNIEGEATAMYISRLL KPSGIKLSRIAHGLPVGGDLEYADEVTLSKALEGRREL*" /label="recR CDS" gene 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /label="recR gene" CDS 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387903.1" /db_xref="EnsemblGenomes-Gn:BSU00220" /db_xref="EnsemblGenomes-Tr:CAB11798" /db_xref="InterPro:IPR019644" /db_xref="SubtiList:BG10086" /db_xref="UniProtKB/Swiss-Prot:P37533" /translation="MGFLRKKTLRREFDEKLTEQLFKQKEEWNRQKKLVEKSLEPSAE VLYELKVAEAKYFFYLREAKQRNLKISRWK*" /label="yaaL CDS" gene 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /label="yaaL gene" promotor_-35 29299..29304 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-35" upshifts 29316 /Source="Nicolas_upshifts" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="upshifts" promotor_-10 29320..29338 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-10" CDS 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15087499, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15087499, 17557826; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the pro-sigma(K) processing machinery" /protein_id="NP_387904.2" /db_xref="EnsemblGenomes-Gn:BSU00230" /db_xref="EnsemblGenomes-Tr:CAB11799" /db_xref="GOA:P24282" /db_xref="InterPro:IPR010001" /db_xref="SubtiList:BG10087" /db_xref="UniProtKB/Swiss-Prot:P24282" /translation="MEPIFIIGIILGLVILLFLSGSAAKPLKWIGITAVKFVAGALLL VCVNMFGGSLGIHVPINLVTTAISGILGIPGIAALVVIKQFII*" /label="bofA CDS" gene 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /label="bofA gene" promotor_-35 29639..29646 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 29660..29679 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 29667..29869 /Source="Nicolas_S_feature" /locus_tag="new_30076_30278" /HighExp="LBGstat, Diami, C30, H2O2, Oxctl, HPh, BMM, GM 120, Paraq, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.899, 0.99" /label="S19" upshifts 29667 /Source="Nicolas_upshifts" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-16S" gene 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /label="rrnA-16S gene" tRNA 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ile(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ile" gene 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /label="trnA-Ile gene" tRNA 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ala" gene 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /label="trnA-Ala gene" rRNA 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-23S" gene 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /label="rrnA-23S gene" S_feature 34695..34827 /Source="Nicolas_S_feature" /locus_tag="new_35104_35236" /HighExp="LBGstat, G135, Oxctl, C30, HPh, Paraq, G180, LPh, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S20" rRNA 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-5S" gene 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /label="rrnA-5S gene" S_feature 34947..35049 /Source="Nicolas_S_feature" /locus_tag="new_35356_35458" /HighExp="Oxctl, Paraq, H2O2, LBGstat, C30, G180, Cold, G135, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S21" promotor_-35 35010..35018 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-35" promotor_-10 35032..35051 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-10" upshifts 35051 /Source="Nicolas_upshifts" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="upshifts" CDS 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8759874, 15044948, 21935351, 26929302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759874, 15044948, 21935351, 26929302; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="forespore-specific anti-sigma factor" /protein_id="NP_387905.1" /db_xref="EnsemblGenomes-Gn:BSU00240" /db_xref="EnsemblGenomes-Tr:CAB11800" /db_xref="GOA:P37534" /db_xref="InterPro:IPR019700" /db_xref="SubtiList:BG10088" /db_xref="UniProtKB/Swiss-Prot:P37534" /translation="MDETVKLNHTCVICDQEKNRGIHLYTKFICLDCERKVISTSTSD PDYAFYVKKLKSIHTPPLYS*" /label="csfB CDS" gene 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /label="csfB gene" downshifts 35300 /Source="Nicolas_upshifts" /id="D12" /incds=0 /nref=79 /ntot=215 /MaxReadThrough="5.37774" /MaxDrop="4.42494" /score="22.3916007" /energy="-6.7" /TU="U28" /idTUdmin="U27" /TUdmin=3938 /isTUend="FALSE" /label="downshifts" promotor_-35 35361..35370 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 35382..35397 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 35388 /Source="Nicolas_upshifts" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23155385; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatase" /protein_id="NP_387906.1" /db_xref="EnsemblGenomes-Gn:BSU00250" /db_xref="EnsemblGenomes-Tr:CAB11801" /db_xref="GOA:P37467" /db_xref="InterPro:IPR018770" /db_xref="SubtiList:BG10089" /db_xref="UniProtKB/Swiss-Prot:P37467" /translation="MQRFFHFLVWSLTSSATFVFIGILSFFGLNQSIFLSIVYGLASG AAVYIAGIWNARRLFLKKHELTGREYAYIKKNLEEARQKMVRLRKALFQAKSIQMFKQ NAEMLRIVRRIYLLTKKEPKRFYQAERFFYQTLDSVVELTEKYAFLSSHPKKSKELSM SLSETRITLTELTKRLEEDLTQAMGDEIDELQFELDAAKHSLKK*" /label="xpaC CDS" gene 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /label="xpaC gene" CDS 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12533473, 20713661" /codon_start=1 /transl_table=11 /product="putative toxic compound resistance protein" /protein_id="NP_387907.1" /db_xref="EnsemblGenomes-Gn:BSU00260" /db_xref="EnsemblGenomes-Tr:CAB11802" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG10090" /db_xref="UniProtKB/Swiss-Prot:P37535" /translation="MNRDQSDLHIDELLADPFGGNIEIPGSEAVKAEKEQVRLVDVLP EENKEKAIQLAGQIDHKNMQSIVLYGSQAQSKLLNFSHDMINHVQKKDVGEIGEILGE LMKKLEQVNPDDLQSKKKGFLARMFGRVSSSLQEVLSKYQKTSVQIDRISLKLEHSKN ALISDNKLLEQLYEKNKEYFAALNVYIAAGELKLEELKTKTIPELKQQAESSDHNQMA VQEVNDLIQFADRLDKRVHDLLLSRQITIQSAPQIRLIQNTNQALAEKIQSSIVTAIP LWKNQVAIALTLLRQRNAVDAQQKVSDTTNELLLKNAELLKTNTIETARANERGLVDI DTLKKVQESLISTLEETLTIQEEGRIKRRQAEEELMMMEGDLKQKLITIKER*" /label="yaaN CDS" gene 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /label="yaaN gene" S_feature 37230..37310 /Source="Nicolas_S_feature" /locus_tag="new_37639_37719" /HighExp="T0.0H, T-0.40H, T0.30H, T-1.10H, T-1.40H, Salt, T1.0H, G150, Diami, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="0.984, 0.715" /TUlongSig="NA" /TUlongPSig="NA" /label="S22" CDS 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9723923, 20876533, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative decarboxylase" /protein_id="NP_387908.1" /db_xref="EnsemblGenomes-Gn:BSU00270" /db_xref="EnsemblGenomes-Tr:CAB11803" /db_xref="GOA:P37536" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10091" /db_xref="UniProtKB/Swiss-Prot:P37536" /translation="MNTPLYKALIQHARRNSHSFHVPGHHNGDVFFDDAKSIFDPLLT IDVTELAGLDDLHHPSGVIKEAQELASQLYGSAESFFLVNGTTVGNLAMILSVCEPGD TILVQRNCHKSVFHAVDLSGAEPVYLAPDVDSAMHVPTHVPLGTIKEALEAYPDAKGL VLTNPTYYGHSADLTEIITEAHHYGIPVLVDEAHGAHFILGEPFPVSALKMGADIVVQ SAHKTLPAMTMGSYLHLNSSCRINRDRVAEYLNRLQSSSPSYPIMASLDIARAYVQHI IEEQKLSDILQRIETLKQTFDSLTNAEAVNPANPLIITDPLKLTIRSKRGHSGYTLQS ILERANIFTELADENQVLLVLPLGGKRRINAEIIRSIDEEIEKTPPDQTFVSAEWGVQ PVTVLPYPKKVLHSFKKEYVSFEEAAGRLNAEDIIPYPPGIPMIMAGERITKESVQKL SRLISMKTHVQGNMKIKEKQLLVYIEEEKS*" /label="yaaO CDS" gene 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /label="yaaO gene" promotor_-35 38673..38679 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-35" promotor_-10 38694..38712 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-10" upshifts 38703 /Source="Nicolas_upshifts" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="upshifts" CDS 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /EC_number="2.7.4.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696781, 12682299, 18523102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696781, 12682299, 18523102; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate kinase" /protein_id="NP_387909.2" /db_xref="EnsemblGenomes-Gn:BSU00280" /db_xref="EnsemblGenomes-Tr:CAB11804" /db_xref="GOA:P37537" /db_xref="InterPro:IPR018094" /db_xref="InterPro:IPR018095" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10092" /db_xref="UniProtKB/Swiss-Prot:P37537" /translation="MSGLFITFEGPEGAGKTTVLQEIKNILTAEGLQVMATREPGGID IAEQIREVILNENNILMDPKTEALLYAAARRQHLVEKVKPALEQGFIVLCDRFIDSSL AYQGYARGLGIDEVLSINEFAIGDMMPHVTVYFSIDPEEGLKRIYANGSREKNRLDLE KLDFHTKVQEGYQELMKRFPERFHSVDAGQSKDLVVQDVLKVIDEALKKIQL*" /label="tmk CDS" gene 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /label="tmk gene" promotor_-35 39383..39390 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 39403..39422 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 39414 /Source="Nicolas_upshifts" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /experiment="publication(s) with functional evidences, PMID:10913081, 25433025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 25433025; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal transduction receptor, cyclic di-AMP binding" /protein_id="NP_387910.1" /db_xref="EnsemblGenomes-Gn:BSU00290" /db_xref="EnsemblGenomes-Tr:CAB11805" /db_xref="InterPro:IPR010375" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="PDB:4RLE" /db_xref="SubtiList:BG10093" /db_xref="UniProtKB/Swiss-Prot:P37538" /translation="MKLIVAVVQDQDSNRLLKTLTDHNFRVTKLATTGGFLKSGNTTF MIGVEDIRVNKALSLIKENGQKRDQMIAPVSPMGGNADSYVPYPVEVEVGGATVFVLP VDEFHQF*" /label="darA CDS" gene 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /label="darA gene" CDS 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387911.1" /db_xref="EnsemblGenomes-Gn:BSU00300" /db_xref="EnsemblGenomes-Tr:CAB11806" /db_xref="InterPro:IPR005585" /db_xref="InterPro:IPR024042" /db_xref="SubtiList:BG10094" /db_xref="UniProtKB/Swiss-Prot:P37539" /translation="MKINKDIRTFIDNKQIPSVKTSEITASFKTSMENQSSKMKLDQL TRLLSDIEAFGKRLTKSRNFKDLARFKGLVKRFVKEAVDSGLSHETSKSFDLYGNSRT LGLVKEIDDKLIQLTEEMMDQEKPAIDLLERIGEIKGLLINLYT*" /label="yaaR CDS" gene 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /label="yaaR gene" CDS 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8509334, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509334, 12060778, 12682299, 22333191, 23525462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III clamp loader delta' subunit" /protein_id="NP_387912.1" /db_xref="EnsemblGenomes-Gn:BSU00310" /db_xref="EnsemblGenomes-Tr:CAB11807" /db_xref="GOA:P37540" /db_xref="InterPro:IPR004622" /db_xref="InterPro:IPR015199" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10095" /db_xref="UniProtKB/Swiss-Prot:P37540" /translation="MAISWKEMNELQPRVMKLLYNSIEKDRLSHAYLFEGKKGTGKLD AALLLAKSFFCLEGGAEPCESCRNCKRIESGNHPDLHLVQPDGLSIKKAQIQALQEEF SKTGLESHKKLYIISHADQMTANAANSLLKFLEEPNKDTMAVLITEQPQRLLDTIISR CQTLPFQPLQPKAIEDRLIEQDVSPHMARLLANMTNNVAEAVELSRNDEFAESRAKVI KLYEVLHQRKGHAFFFIQDQWMPFFKEKTHQEMGLDMLLLIYRDVLSIQIGNEDKLIY QDLFQSIKQHALQSTQQSVTNQILAVLEAKKRLHSNVNVQGLMEHLVLMLQEG*" /label="holB CDS" gene 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /label="holB gene" CDS 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12270811, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12270811, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex of RNaseY (RicAFT complex /FAD / two [4Fe-4S]2+)" /protein_id="NP_387913.1" /db_xref="EnsemblGenomes-Gn:BSU00320" /db_xref="EnsemblGenomes-Tr:CAB11808" /db_xref="GOA:P37541" /db_xref="InterPro:IPR007557" /db_xref="SubtiList:BG10096" /db_xref="UniProtKB/Swiss-Prot:P37541" /translation="MYNVIGVRFKKAGKIYYFDPNGFHIEHDSCVIVETVRGVEYGQV VIANKQVDEHDVVLPLRKVIRVADDRDLLIVEENKQEALSAFDICQKKVIEHGLDMKL VDVEFTFDRNKVIFYFTADGRVDFRELVKDLASIFKTRIELRQIGVRDEAKMLGGIGP CGRMLCCSTFLGDFEPVSIKMAKDQNLSLNPTKISGLCGRLMCCLKYENDEYETAKEQ LPDIGEMITTANGPAKVVGLNILERVLQVELINREKVIEYTWEELLEEGVVSAQTTD* " /label="ricT CDS" gene 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /label="ricT gene" CDS 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15927750, 16461910, 19737352, 21895792, 23909787, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15927750, 16461910, 19737352, 21895792, 23909787, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="subunit of the DNA replication complex" /protein_id="NP_387914.1" /db_xref="EnsemblGenomes-Gn:BSU00330" /db_xref="EnsemblGenomes-Tr:CAB11809" /db_xref="GOA:P37542" /db_xref="InterPro:IPR010377" /db_xref="PDB:5DOL" /db_xref="SubtiList:BG10097" /db_xref="UniProtKB/Swiss-Prot:P37542" /translation="MDKKELFDTVINLEEQIGSLYRQLGDLKQHIGEMIEENHHLQLE NKHLRKRLDDTTQQIEKFKADKKESKTQKTEQTDIGEGYDNLARLYQEGFHICNVHYG SVRKEDCLFCLSFLNKK*" /label="dnaH CDS" gene 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /label="dnaH gene" CDS 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /EC_number="2.1.1.223" /function="10.3: tRNA and rRNA base modification" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22905870, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase" /protein_id="NP_387915.1" /db_xref="EnsemblGenomes-Gn:BSU00340" /db_xref="EnsemblGenomes-Tr:CAB11810" /db_xref="GOA:P37543" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10098" /db_xref="UniProtKB/Swiss-Prot:P37543" /translation="MVSLHDDERLDYLLAEDMKIIQSPTVFAFSLDAVLLSKFAYVPI QKGKIVDLCTGNGIVPLLLSTRSKADILGVEIQERLHDMAVRSVEYNKLDDQIQIIHD DLKNMPEKLGHNRYDVVTCNPPYFKTPKQTEQNMNEHLRIARHEIHCTLEDVISVSSK LLKQGGKAALVHRPGRLLEIFELMKAYQIEPKRVQFVYPKQGKEANTILVEGIKGGRP DLKILPPLFVYDEQNEYTKEIRTILYGDK*" /label="trmNF CDS" gene 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /label="trmNF gene" CDS 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11483577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UvrC-Intron-type (URI) endonuclease" /protein_id="NP_387916.1" /db_xref="EnsemblGenomes-Gn:BSU00350" /db_xref="EnsemblGenomes-Tr:CAB11811" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG12700" /db_xref="UniProtKB/Swiss-Prot:O31414" /translation="METNNHFFYVVKCKDNSWYAGYTNDLHKRVKTHNDGKGAKYTKV RRPVELIFAESFSTKREAMQAEYYFKKLTRKKKELYIEEKRNSKEAVYVKAPNEL*" /label="yazA CDS" gene 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /label="yazA gene" CDS 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /EC_number="2.1.1.198" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 19965768, 25893373; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA 2'-O-ribose C1402 methyltransferase" /protein_id="NP_387917.1" /db_xref="EnsemblGenomes-Gn:BSU00360" /db_xref="EnsemblGenomes-Tr:CAB11812" /db_xref="GOA:P37544" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR008189" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR018063" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10099" /db_xref="UniProtKB/Swiss-Prot:P37544" /translation="MLRRQMSFNGKSDMGILYLVPTPIGNLEDMTFRAIDTLKSVDAI AAEDTRQTKKLCHVYEIETPLVSYHEHNKESSGHKIIEWLKSGKNIALVSDAGLPTIS DPGAEIVKDFTDIGGYVVPLPGANAALTALIASGIVPQPFFFYGFLNRQKKEKKKELE ALKKRQETIIFYEAPHRLKETLSAMAEILGDREIAVTRELTKKYEEFIRGTISEVIGW ANEDQIRGEFCLVVEGSNNEEVDEEEQWWETLTAKEHVEHYISKGATSKEAIKKAAVD RNVPKREVYDAYHIKQ*" /label="rsmI CDS" gene 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /label="rsmI gene" downshifts 44363 /Source="Nicolas_upshifts" /id="D13" /incds=0 /nref=23 /ntot=177 /MaxReadThrough="3.33195" /MaxDrop="3.72723" /score="5.97354542" /energy="-10.2" /TU="U29,U31" /idTUdmin="U29" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for transition state genes (AbrB-SurF)" /protein_id="NP_387918.1" /db_xref="EnsemblGenomes-Gn:BSU00370" /db_xref="EnsemblGenomes-Tr:CAB11813" /db_xref="GOA:P08874" /db_xref="InterPro:IPR007159" /db_xref="PDB:1YFB" /db_xref="PDB:1YSF" /db_xref="PDB:1Z0R" /db_xref="PDB:2K1N" /db_xref="PDB:2MJG" /db_xref="PDB:2RO4" /db_xref="SubtiList:BG10100" /db_xref="UniProtKB/Swiss-Prot:P08874" /translation="MFMKSTGIVRKVDELGRVVIPIELRRTLGIAEKDALEIYVDDEK IILKKYKPNMTCQVTGEVSDDNLKLAGGKLVLSKEGAEQIISEIQNQLQNLK*" /label="abrB CDS" gene complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /label="abrB gene" downshifts complement(44441) /Source="Nicolas_upshifts" /id="D14" /incds=0 /nref=216 /ntot=263 /MaxReadThrough="2.17237" /MaxDrop="7.75729" /score="20.9582436" /energy="-10.2" /TU="U32" /idTUdmin="U32" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 44760 /Source="Nicolas_upshifts" /id="D15" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="2.53543" /MaxDrop="4.31699" /score="13.7153159" /energy="-14.4" /TU="NA" /idTUdmin="U29" /TUdmin=374 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(44796..44815) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(44813) /Source="Nicolas_upshifts" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(44815..44990) /Source="Nicolas_S_feature" /locus_tag="new_45224_45399_c" /HighExp="C30, H2O2, G180, Etha, S0, GM 25, Gly, G135, MG 25, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S23" promotor_-35 complement(44829..44836) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(44986..45005) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-10" upshifts complement(44990) /Source="Nicolas_upshifts" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="upshifts" promotor_-35 complement(45019..45026) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-35" promotor_-35 45090..45094 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-35" promotor_-10 45109..45128 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-10" S_feature 45115..45223 /Source="Nicolas_S_feature" /locus_tag="new_45524_45632" /HighExp="LBGtran, Heat, dia5, dia15, LBGexp, Lbexp, dia0, H2O2, Diami, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S24" upshifts 45115 /Source="Nicolas_upshifts" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="upshifts" CDS 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /EC_number="6.1.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11233169, 12682299, 12792655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA synthetase" /protein_id="NP_387919.1" /db_xref="EnsemblGenomes-Gn:BSU00380" /db_xref="EnsemblGenomes-Tr:CAB11814" /db_xref="GOA:P37465" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004495" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014758" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR023457" /db_xref="InterPro:IPR033911" /db_xref="SubtiList:BG10101" /db_xref="UniProtKB/Swiss-Prot:P37465" /translation="MPQENNTFYITTPIYYPSGKLHIGHAYTTVAGDAMARYKRLKGF DVRYLTGTDEHGQKIQQKAEQENITPQEYVDRAAADIQKLWKQLEISNDDFIRTTEKR HKVVIEKVFQKLLDNGDIYLDEYEGWYSIPDETFYTETQLVDIERNEKGEVIGGKSPD SGHPVELIKEESYFFRMGKYADRLLKYYEENPTFIQPESRKNEMINNFIKPGLEDLAV SRTTFDWGVKVPENPKHVVYVWIDALFNYLTALGYDTENDELYQKYWPADVHLVGKEI VRFHTIYWPIMLMALDLPLPKQVFAHGWLLMKDGKMSKSKGNVVDPVTLIERYGLDEL RYYLLREVPFGSDGVFTPEGFVERINYDLANDLGNLLNRTVAMINKYFDGQIGSYKGA VTEFDHTLTSVAEETVKAYEKAMENMEFSVALSTLWQLISRTNKYIDETAPWVLAKDP AKEEELRSVMYHLAESLRISAVLLQPFLTKTPEKMFEQLGITDESLKAWDSITAFGQL KDTKVQKGEPLFPRLEAEEEIAYIKGKMQGSAPAKEETKEEEPQEVDRLPEITIDQFM DVELRVAEVIEAEPVKKADRLLKLQLDLGFEKRQVVSGIAKHYTPEELVGKKLVCVTN LKPVKLRGELSQGMILAGEADGVLKVVSIDQSLPKGTRIK*" /label="metS CDS" gene 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /label="metS gene" promotor_-10 complement(45972..45991) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(45980) /Source="Nicolas_upshifts" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(46007..46011) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 47202 /Source="Nicolas_upshifts" /id="D16" /incds=0 /nref=18 /ntot=206 /MaxReadThrough="4.8491" /MaxDrop="2.9167" /score="13.7153159" /energy="-14.4" /TU="U34" /idTUdmin="U34" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" S_feature complement(47264..49610) /Source="Nicolas_S_feature" /locus_tag="new_47673_50019_c" /HighExp="T0.30H, T1.0H, T1.30H, Salt, C30, T2.0H, T-0.40H, T0.0H, T2.30H, T-1.10H" /AntisenseName="yabE" /AntisenseCor="-0.28154713646185298" /AntisenseRegPval="-5.6" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S25" CDS 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10747959, 16014871, 16461678, 19332551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acyl-tRNA deacylase" /protein_id="NP_387920.1" /db_xref="EnsemblGenomes-Gn:BSU00390" /db_xref="EnsemblGenomes-Tr:CAB11815" /db_xref="GOA:P37545" /db_xref="InterPro:IPR001130" /db_xref="InterPro:IPR015991" /db_xref="InterPro:IPR018228" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10102" /db_xref="UniProtKB/Swiss-Prot:P37545" /translation="MLFDTHAHLNAEQYDTDLEEVIERAKAEKVERIVVVGFDRPTIT RAMEMIEEYDFIYAAIGWHPVDAIDMTEEDLAWIKELSAHEKVVAIGEMGLDYHWDKS PKDIQKEVFRNQIALAKEVNLPIIIHNRDATEDVVTILKEEGAEAVGGIMHCFTGSAE VARECMKMNFYLSFGGPVTFKNAKKPKEVVKEIPNDRLLIETDCPFLTPHPFRGKRNE PSYVKYVAEQIAELKEMTFEEIASITTENAKRLFRIN*" /label="dayD CDS" gene 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /label="dayD gene" S_feature 48065..48145 /Source="Nicolas_S_feature" /locus_tag="new_48474_48554" /HighExp="Heat, C30, LBGtran, LBGstat, C90, Etha, M40t45, LPhT, MG 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S26" promotor_-35 48122..48127 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 48143..48161 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 48147 /Source="Nicolas_upshifts" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 48172..48175 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-35" promotor_-10 48190..48209 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-10" upshifts 48207 /Source="Nicolas_upshifts" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="upshifts" CDS 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15774001, 19047346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall shaping enzyme" /protein_id="NP_387921.1" /db_xref="EnsemblGenomes-Gn:BSU00400" /db_xref="EnsemblGenomes-Tr:CAB11816" /db_xref="GOA:P37546" /db_xref="InterPro:IPR007137" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR011098" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG10103" /db_xref="UniProtKB/Swiss-Prot:P37546" /translation="MGEREGRVDSLLDTLYNLSEEKEAFFITQKMKKLFSVKLSKSKV ILVAACLLLAGSGTAYAAHELTKQSVSVSINGKKKHIRTHANTVGDLLETLDIKTRDE DKITPAKQTKITADMDVVYEAAKPVKLTINGEEKTLWSTAKTVGALLDEQDVDVKEQD QIDPAIDTDISKDMKINIEPAFQVTVNDAGKQKKIWTTSTTVADFLKQQKMNIKDEDK IKPALDAKLTKGKADITITRIEKVTDVVEEKIAFDVKKQEDASLEKGKEKVVQKGKEG KLKKHFEVVKENGKEVSRELVKEETAEQSKDKVIAVGTKQSSPKFETVSASGDSKTVV SRSNESTGKVMTVSSTAYTASCSGCSGHTATGVNLKNNPNAKVIAVDPNVIPLGSKVH VEGYGYAIAADTGSAIKGNKIDVFFPEKSSAYRWGNKTVKIKILN*" /label="yabE CDS" gene 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /label="yabE gene" promotor_-35 48240..48247 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 48258 /Source="Nicolas_upshifts" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 48262..48281 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 49494 /Source="Nicolas_upshifts" /id="D17" /incds=0 /nref=87 /ntot=220 /MaxReadThrough="5.02755" /MaxDrop="4.87493" /score="27.529638" /energy="-11.3" /TU="U36,U37,U38" /idTUdmin="U34" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-35 49556..49560 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 49576..49595 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 49578..49677 /Source="Nicolas_S_feature" /locus_tag="new_49987_50086" /HighExp="LoTm, H2O2, G180, G135, G150, Paraq, Oxctl, C30, dia15, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.843, 0.943" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S27" upshifts 49578 /Source="Nicolas_upshifts" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(49602..49617) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(49618) /Source="Nicolas_upshifts" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(49629..49638) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 49674..49690 /Source="Nicolas_upshift_promotors" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /EC_number="3.1.26.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11233981, 11976317, 12794188, 16077031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11233981, 11976317, 12794188, 16077031; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease M5" /protein_id="NP_387922.1" /db_xref="EnsemblGenomes-Gn:BSU00410" /db_xref="EnsemblGenomes-Tr:CAB11817" /db_xref="GOA:P37547" /db_xref="InterPro:IPR004466" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR025156" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG10104" /db_xref="UniProtKB/Swiss-Prot:P37547" /translation="MKIKEIIVVEGRDDTARIKLAVDADTIETNGSAIDDHVIDQIRL AQKTRGVIILTDPDFPGEKIRKTISEAVPGCKHAFLPKHLAKPKNKRGIGVEHASVES IRACLENVHEEMEAQPSDISAEDLIHAGLIGGPAAKCRRERLGDLLKIGYTNGKQLQK RLQMFQIKKSDFMSALDTVMREEQNE*" /label="rnmV CDS" gene 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /label="rnmV gene" upshifts 49688 /Source="Nicolas_upshifts" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" CDS 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 99430, 6801425, 11327780, 1690648, 22391551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dimethyladenosine 16S ribosomal RNA transferase" /protein_id="NP_387923.1" /db_xref="EnsemblGenomes-Gn:BSU00420" /db_xref="EnsemblGenomes-Tr:CAB11818" /db_xref="GOA:P37468" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR011530" /db_xref="InterPro:IPR020596" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023165" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10105" /db_xref="UniProtKB/Swiss-Prot:P37468" /translation="MNKDIATPIRTKEILKKYGFSFKKSLGQNFLIDTNILNRIVDHA EVTEKTGVIEIGPGIGALTEQLAKRAKKVVAFEIDQRLLPILKDTLSPYENVTVIHQD VLKADVKSVIEEQFQDCDEIMVVANLPYYVTTPIIMKLLEEHLPLKGIVVMLQKEVAE RMAADPSSKEYGSLSIAVQFYTEAKTVMIVPKTVFVPQPNVDSAVIRLILRDGPAVDV ENESFFFQLIKASFAQRRKTLLNNLVNNLPEGKAQKSTIEQVLEETNIDGKRRGESLS IEEFAALSNGLYKALF*" /label="rsmA CDS" gene 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /label="rsmA gene" downshifts 51074 /Source="Nicolas_upshifts" /id="D18" /incds=0 /nref=152 /ntot=229 /MaxReadThrough="3.0815" /MaxDrop="4.58632" /score="20.4155562" /energy="-9.4" /TU="NA" /idTUdmin="U36" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 51124..51133 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 51147..51166 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 51149..51270 /Source="Nicolas_S_feature" /locus_tag="new_51558_51679" /HighExp="S7, S6, S8, BT, S5, B36, G/S, Pyr, B60, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S28" upshifts 51149 /Source="Nicolas_upshifts" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="upshifts" CDS 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 11040425, 16751597, 19060142, 19833771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 11040425, 16751597, 19060142, 19833771; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protease" /protein_id="NP_387924.1" /db_xref="EnsemblGenomes-Gn:BSU00430" /db_xref="EnsemblGenomes-Tr:CAB11819" /db_xref="GOA:P37548" /db_xref="InterPro:IPR008764" /db_xref="SubtiList:BG10106" /db_xref="UniProtKB/Swiss-Prot:P37548" /translation="MQFQIGDMVARKSYQMDVLFRIIGIEQTSKGNSIAILHGDEVRL IADSDFSDLVAVKKDEQMMRKKKDESRMNESLELLRQDYKLLREKQEYYATSQYQHQE HYFHMPGKVLHLDGDEAYLKKCLNVYKKIGVPVYGIHCHEKKMSASIEVLLDKYRPDI LVITGHDAYSKQKGGIDDLNAYRHSKHFVETVQTARKKIPHLDQLVIFAGACQSHFES LIRAGANFASSPSRVNIHALDPVYIVAKISFTPFMERINVWEVLRNTLTREKGLGGIE TRGVLRIGMPYKSN*" /label="prtG CDS" gene 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /label="prtG gene" downshifts 52130 /Source="Nicolas_upshifts" /id="D19" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.30424" /MaxDrop="7.1507" /score="26.6672651" /energy="-11.5" /TU="NA" /idTUdmin="U42" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 52240..52310 /Source="Nicolas_S_feature" /locus_tag="new_52649_52719" /HighExp="S8, S5, S7, S6, S4, BT, LoTm, G/S, nit, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S29" promotor_-35 52301..52308 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 52312 /Source="Nicolas_upshifts" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 52322..52341 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(52331..52345) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(52338) /Source="Nicolas_upshifts" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(52354..52358) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12761295, 22720735, 23378512; Producttype ph: phenotype" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387925.1" /db_xref="EnsemblGenomes-Gn:BSU00440" /db_xref="EnsemblGenomes-Tr:CAB11820" /db_xref="GOA:P37466" /db_xref="InterPro:IPR009366" /db_xref="SubtiList:BG10107" /db_xref="UniProtKB/Swiss-Prot:P37466" /translation="MAKTLSDIKRSLDGNLGKRLTLKANGGRRKTIERSGILAETYPS VFVIQLDQDENSFERVSYSYADILTETVELTFNDDAASSVAF*" /label="veg CDS" gene 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /label="veg gene" downshifts 52526 /Source="Nicolas_upshifts" /id="D20" /incds=1 /nref=4 /ntot=158 /MaxReadThrough="8.09861" /MaxDrop="2.7867" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U42" /TUdmin=396 /isTUend="FALSE" /label="downshifts" downshifts 52613 /Source="Nicolas_upshifts" /id="D21" /incds=0 /nref=191 /ntot=264 /MaxReadThrough="5.88511" /MaxDrop="6.03144" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U43" /TUdmin="-331" /isTUend="FALSE" /label="downshifts" promotor_-35 52679..52685 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 52699..52710 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 52702..52773 /Source="Nicolas_S_feature" /locus_tag="new_53111_53182" /HighExp="S8, Cold, S6, S7, ferm, S5, nit, Etha, G135, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S30" upshifts 52702 /Source="Nicolas_upshifts" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="upshifts" CDS 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7959056, 8982008, 11092849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7959056, 8982008, 11092849; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_387926.1" /db_xref="EnsemblGenomes-Gn:BSU00450" /db_xref="EnsemblGenomes-Tr:CAB11821" /db_xref="GOA:P37549" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10108" /db_xref="UniProtKB/Swiss-Prot:P37549" /translation="MGRRRGVMSDEFKYELAKDLGFYDTVKNGGWGEIRARDAGNMVK RAIEIAEQQMAQNQNNR*" /label="sspF CDS" gene 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /label="sspF gene" downshifts 52944 /Source="Nicolas_upshifts" /id="D22" /incds=0 /nref=54 /ntot=153 /MaxReadThrough="2.67408" /MaxDrop="6.21058" /score="38.1065567" /energy="-12.6" /TU="NA" /idTUdmin="U43" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(52954..55308) /Source="Nicolas_S_feature" /locus_tag="new_53363_55717_c" /HighExp="S5, S4, S6, T5.0H, S3, S8, S7, T4.0H, T3.30H, C30" /AntisenseName="ispE" /AntisenseCor="-0.66604185700913698" /AntisenseRegPval="-35.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S31" promotor_-35 53037..53041 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-35" promotor_-10 53057..53076 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-10" upshifts 53060 /Source="Nicolas_upshifts" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="upshifts" CDS 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /EC_number="2.7.1.148" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11361082, 12682299, 12771135, 17458547, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase" /protein_id="NP_387927.1" /db_xref="EnsemblGenomes-Gn:BSU00460" /db_xref="EnsemblGenomes-Tr:CAB11822" /db_xref="GOA:P37550" /db_xref="InterPro:IPR004424" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10109" /db_xref="UniProtKB/Swiss-Prot:P37550" /translation="MRILEKAPAKINLSLDVTRKRPDGYHEVEMIMTTIDLADRIELT ELAEDEVRVSSHNRFVPDDQRNLAYQAAKLIKDRYNVKKGVSIMITKVIPVAAGLAGG SSDAAATLRGLNRLWNLNLSAETLAELGAEIGSDVSFCVYGGTALATGRGEKIKHIST PPHCWVILAKPTIGVSTAEVYRALKLDGIEHPDVQGMIEAIEEKSFQKMCSRLGNVLE SVTLDMHPEVAMIKNQMKRFGADAVLMSGSGPTVFGLVQYESKVQRIYNGLRGFCDQV YAVRMIGEQNALD*" /label="ispE CDS" gene 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /label="ispE gene" CDS 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11591660, 12837783, 12837784, 15629952, 16163456, 27329548" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12837783, 12837784, 15629952, 16163456, 27329548; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine biosynthesis operon (PurR-pRpp)" /protein_id="NP_387928.1" /db_xref="EnsemblGenomes-Gn:BSU00470" /db_xref="EnsemblGenomes-Tr:CAB11823" /db_xref="GOA:P37551" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010078" /db_xref="InterPro:IPR015265" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1O57" /db_xref="PDB:1P4A" /db_xref="SubtiList:BG10110" /db_xref="UniProtKB/Swiss-Prot:P37551" /translation="MKFRRSGRLVDLTNYLLTHPHELIPLTFFSERYESAKSSISEDL TIIKQTFEQQGIGTLLTVPGAAGGVKYIPKMKQAEAEEFVQTLGQSLANPERILPGGY VYLTDILGKPSVLSKVGKLFASVFAEREIDVVMTVATKGIPLAYAAASYLNVPVVIVR KDNKVTEGSTVSINYVSGSSNRIQTMSLAKRSMKTGSNVLIIDDFMKAGGTINGMINL LDEFNANVAGIGVLVEAEGVDERLVDEYMSLLTLSTINMKEKSIEIQNGNFLRFFKDN LLKNGETES*" /label="purR CDS" gene 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /label="purR gene" CDS 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /EC_number="3.5.99.10" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2113912, 12515541, 14729707, 10557275, 10919400, 10368157, 20562306, 23815688; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminoacrylate/iminopropionate hydrolase/deaminase" /protein_id="NP_387929.1" /db_xref="EnsemblGenomes-Gn:BSU00480" /db_xref="EnsemblGenomes-Tr:CAB11824" /db_xref="GOA:P37552" /db_xref="InterPro:IPR006056" /db_xref="InterPro:IPR006175" /db_xref="InterPro:IPR019897" /db_xref="InterPro:IPR035959" /db_xref="PDB:1QD9" /db_xref="SubtiList:BG10111" /db_xref="UniProtKB/Swiss-Prot:P37552" /translation="MTKAVHTKHAPAAIGPYSQGIIVNNMFYSSGQIPLTPSGEMVNG DIKEQTHQVFSNLKAVLEEAGASFETVVKATVFIADMEQFAEVNEVYGQYFDTHKPAR SCVEVARLPKDALVEIEVIALVK*" /label="ridA CDS" gene 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /label="ridA gene" downshifts 55253 /Source="Nicolas_upshifts" /id="D23" /incds=0 /nref=172 /ntot=226 /MaxReadThrough="3.8891" /MaxDrop="4.63425" /score="22.9159767" /energy="-12.3" /TU="U46" /idTUdmin="U46" /TUdmin="-155" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(55297..55315) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 55298..55406 /Source="Nicolas_S_feature" /locus_tag="new_55707_55815" /HighExp="S8, S7, Etha, B36, LoTm, C30, Sw, B60, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S32" upshifts complement(55309) /Source="Nicolas_upshifts" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(55331..55336) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 55386..55394 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-35" promotor_-10 55405..55423 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-10" upshifts 55408 /Source="Nicolas_upshifts" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="upshifts" CDS 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733708, 10348850, 10648512, 16428420, 27048798" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733708, 10348850, 10648512, 16428420, 27048798; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for spore cortex synthesis (stage V sporulation)" /protein_id="NP_387930.1" /db_xref="EnsemblGenomes-Gn:BSU00490" /db_xref="EnsemblGenomes-Tr:CAB11825" /db_xref="GOA:P28015" /db_xref="InterPro:IPR007170" /db_xref="InterPro:IPR036751" /db_xref="PDB:2IA9" /db_xref="SubtiList:BG10112" /db_xref="UniProtKB/Swiss-Prot:P28015" /translation="MEVTDVRLRRVNTDGRMRAIASITLDHEFVVHDIRVIDGNNGLF VAMPSKRTPDGEFRDITHPINSSTRGKIQDAVLNEYHRLGDTEALEFEEAGAS*" /label="spoVG CDS" gene 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /label="spoVG gene" downshifts 55739 /Source="Nicolas_upshifts" /id="D24" /incds=0 /nref=263 /ntot=285 /MaxReadThrough="5.11673" /MaxDrop="7.2673" /score="19.392304" /energy="-22.3" /TU="U48" /idTUdmin="U46" /TUdmin=331 /isTUend="FALSE" /label="downshifts" S_feature 55784..55895 /Source="Nicolas_S_feature" /locus_tag="new_56193_56304" /HighExp="B60, B36, M9-stat, S2, BT, LoTm, Etha, Lbstat, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S33" promotor_-35 55877..55881 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 55897..55916 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 55897 /Source="Nicolas_upshifts" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /EC_number="2.3.1.157" /EC_number="2.7.7.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional glucosamine-1-phosphate N-acetyltransferase/UDP-N-acetylglucosamine pyrophosphorylase" /protein_id="NP_387931.1" /db_xref="EnsemblGenomes-Gn:BSU00500" /db_xref="EnsemblGenomes-Tr:CAB11826" /db_xref="GOA:P14192" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005882" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10113" /db_xref="UniProtKB/Swiss-Prot:P14192" /translation="MDKRFAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDEALKL SLSKLVTIVGHGAEEVKKQLGDKSEYALQAKQLGTAHAVKQAQPFLADEKGVTIVICG DTPLLTAETMEQMLKEHTQREAKATILTAVAEDPTGYGRIIRSENGAVQKIVEHKDAS EEERLVTEINTGTYCFDNEALFRAIDQVSNDNAQGEYYLPDVIEILKNEGETVAAYQT GNFQETLGVNDRVALSQAEQFMKERINKRHMQNGVTLIDPMNTYISPDAVIGSDTVIY PGTVIKGEVQIGEDTIIGPHTEIMNSAIGSRTVIKQSVVNHSKVGNDVNIGPFAHIRP DSVIGNEVKIGNFVEIKKTQFGDRSKASHLSYVGDAEVGTDVNLGCGSITVNYDGKNK YLTKIEDGAFIGCNSNLVAPVTVGEGAYVAAGSTVTEDVPGKALAIARARQVNKDDYV KNIHKK*" /label="glmU CDS" gene 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /label="glmU gene" downshifts complement(57288) /Source="Nicolas_upshifts" /id="D25" /incds=0 /nref=5 /ntot=84 /MaxReadThrough="2.39379" /MaxDrop="3.65636" /score="-7.65702938" /energy="-13.8" /TU="NA" /idTUdmin="U47" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" CDS 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /EC_number="2.7.6.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2169413, 3038693, 8522540, 22083279, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2169413, 3038693, 8522540, 22083279, 25890046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylpyrophosphate synthetase" /protein_id="NP_387932.1" /db_xref="EnsemblGenomes-Gn:BSU00510" /db_xref="EnsemblGenomes-Tr:CAB11827" /db_xref="GOA:P14193" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR000842" /db_xref="InterPro:IPR005946" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR029099" /db_xref="PDB:1DKR" /db_xref="PDB:1DKU" /db_xref="PDB:1IBS" /db_xref="SubtiList:BG10114" /db_xref="UniProtKB/Swiss-Prot:P14193" /translation="MSNQYGDKNLKIFSLNSNPELAKEIADIVGVQLGKCSVTRFSDG EVQINIEESIRGCDCYIIQSTSDPVNEHIMELLIMVDALKRASAKTINIVIPYYGYAR QDRKARSREPITAKLFANLLETAGATRVIALDLHAPQIQGFFDIPIDHLMGVPILGEY FEGKNLEDIVIVSPDHGGVTRARKLADRLKAPIAIIDKRRPRPNVAEVMNIVGNIEGK TAILIDDIIDTAGTITLAANALVENGAKEVYACCTHPVLSGPAVERINNSTIKELVVT NSIKLPEEKKIERFKQLSVGPLLAEAIIRVHEQQSVSYLFS*" /label="prs CDS" gene 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /label="prs gene" promotor_-35 58302..58308 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 58321 /Source="Nicolas_upshifts" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 58323..58341 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8522540, 9669336, 10369900, 12432960, 17198710" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8522540, 9669336, 10369900, 12432960, 17198710; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein BL25 (Ctc), binding 5S RNA" /protein_id="NP_387933.1" /db_xref="EnsemblGenomes-Gn:BSU00520" /db_xref="EnsemblGenomes-Tr:CAB11828" /db_xref="GOA:P14194" /db_xref="InterPro:IPR001021" /db_xref="InterPro:IPR011035" /db_xref="InterPro:IPR020056" /db_xref="InterPro:IPR020057" /db_xref="InterPro:IPR029751" /db_xref="InterPro:IPR037121" /db_xref="SubtiList:BG10115" /db_xref="UniProtKB/Swiss-Prot:P14194" /translation="MATLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDS VELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLKNEITHADFQVVNMSEDIEVE VPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPA GGDYSFNHESDEVVASILPPQQQEAAEVDEEESADAQPEGENEQ*" /label="ctc CDS" gene 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /label="ctc gene" downshifts 58972 /Source="Nicolas_upshifts" /id="D26" /incds=0 /nref=120 /ntot=249 /MaxReadThrough="8.65206" /MaxDrop="5.4784" /score="1.94770319" /energy="-11.2" /TU="U49,U50" /idTUdmin="U48" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /EC_number="3.1.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8635758, 12100553, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8635758, 12100553, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-tRNA hydrolase" /protein_id="NP_387934.1" /db_xref="EnsemblGenomes-Gn:BSU00530" /db_xref="EnsemblGenomes-Tr:CAB11829" /db_xref="GOA:P37470" /db_xref="InterPro:IPR001328" /db_xref="InterPro:IPR018171" /db_xref="InterPro:IPR036416" /db_xref="SubtiList:BG10116" /db_xref="UniProtKB/Swiss-Prot:P37470" /translation="MLVIAGLGNPGKNYENTRHNVGFMVIDQLAKEWNIELNQNKFNG LYGTGFVSGKKVLLVKPLTYMNLSGECLRPLMDYYDVDNEDLTVIYDDLDLPTGKIRL RTKGSAGGHNGIKSLIQHLGTSEFDRIRIGIGRPVNGMKVVDYVLGSFTKEEAPEIEE AVDKSVKACEASLSKPFLEVMNEFNAKV*" /label="pth CDS" gene 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /label="pth gene" misc_feature 59274..59277 /Source="Nicolas_upshift_promotors" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 59280 /Source="Nicolas_upshifts" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /experiment="publication(s) with functional evidences, PMID:21037003, 28598017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21037003, 28598017; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein required for the switch from F to G during sporulation (anti sigma F)" /protein_id="NP_387935.1" /db_xref="EnsemblGenomes-Gn:BSU00540" /db_xref="EnsemblGenomes-Tr:CAB11830" /db_xref="GOA:P37553" /db_xref="InterPro:IPR020115" /db_xref="PDB:5MSL" /db_xref="SubtiList:BG10117" /db_xref="UniProtKB/Swiss-Prot:P37553" /translation="MALHYYCRHCGVKVGSLESSMVSTDSLGFQHLTNEERNDMISYK ENGDVHVLTICEDCQEALDRNPHYHEYHTFIQ*" /label="fin CDS" gene 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /label="fin gene" S_feature 59952..60020 /Source="Nicolas_S_feature" /locus_tag="new_60361_60429" /HighExp="Etha, S5, S4, S7, S8, S6, S3, H2O2, Diami, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigB, SigA" /TUshortPSig="0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S34" CDS 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription-repair coupling factor" /protein_id="NP_387936.1" /db_xref="EnsemblGenomes-Gn:BSU00550" /db_xref="EnsemblGenomes-Tr:CAB11831" /db_xref="GOA:P37474" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR004576" /db_xref="InterPro:IPR005118" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG10118" /db_xref="UniProtKB/Swiss-Prot:P37474" /translation="MDNIQTFIKESDDFKSIINGLHEGLKEQLLAGLSGSARSVFTSA LANETNKPIFLITHNLYQAQKVTDDLTSLLEDRSVLLYPVNELISSEIAVASPELRAQ RLDVINRLTNGEAPIVVAPVAAIRRMLPPVEVWKSSQMLIQVGHDIEPDQLASRLVEV GYERSDMVSAPGEFSIRGGIIDIYPLTSENPVRIELFDTEVDSIRSFNSDDQRSIETL TSINIGPAKELIIRPEEKARAMEKIDSGLAASLKKLKADKQKEILHANISHDKERLSE GQTDQELVKYLSYFYEKPASLLDYTPDNTLLILDEVSRIHEMEEQLQKEEAEFITNLL EEGKILHDIRLSFSFQKIVAEQKRPLLYYSLFLRHVHHTSPQNIVNVSGRQMQSFHGQ MNVLAGEMERFKKSNFTVVFLGANKERTQKLSSVLADYDIEAAMTDSKKALVQGQVYI MEGELQSGFELPLMKLAVITEEELFKNRVKKKPRKQKLTNAERIKSYSELQIGDYVVH INHGIGKYLGIETLEINGIHKDYLNIHYQGSDKLYVPVEQIDQVQKYVGSEGKEPKLY KLGGSEWKRVKKKVETSVQDIADDLIKLYAEREASKGYAFSPDHEMQREFESAFPYQE TEDQLRSIHEIKKDMERERPMDRLLCGDVGYGKTEVAIRAAFKAIGDGKQVALLVPTT ILAQQHYETIKERFQDYPINIGLLSRFRTRKEANETIKGLKNGTVDIVIGTHRLLSKD VVYKDLGLLIIDEEQRFGVTHKEKIKQIKANVDVLTLTATPIPRTLHMSMLGVRDLSV IETPPENRFPVQTYVVEYNGALVREAIERELARGGQVYFLYNRVEDIERKADEISMLV PDAKVAYAHGKMTENELETVMLSFLEGESDVLVSTTIIETGVDIPNVNTLIVFDADKM GLSQLYQLRGRVGRSNRVAYAYFTYRRDKVLTEVAEKRLQAIKEFTELGSGFKIAMRD LTIRGAGNLLGAQQHGFIDSVGFDLYSQMLKEAIEERKGDTAKTEQFETEIDVELDAY IPETYIQDGKQKIDMYKRFRSVATIEEKNELQDEMIDRFGNYPKEVEYLFTVAEMKVY ARQERVELIKQDKDAVRLTISEEASAEIDGQKLFELGNQYGRQIGLGMEGKKLKISIQ TKGRSADEWLDTVLGMLKGLKDVKKQTISST*" /label="mfd CDS" gene 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /label="mfd gene" promotor_-35 63572..63578 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 63592..63689 /Source="Nicolas_S_feature" /locus_tag="new_64001_64098" /HighExp="S5, S7, S8, S6, S4, Etha, S3, H2O2, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, Sig-, SigB, SigA" /TUshortPSig="1, 0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S35" promotor_-10 63592..63603 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 63592 /Source="Nicolas_upshifts" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of sporulation / germination" /protein_id="NP_387937.1" /db_xref="EnsemblGenomes-Gn:BSU00560" /db_xref="EnsemblGenomes-Tr:CAB11832" /db_xref="GOA:P37554" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR014213" /db_xref="PDB:2RO5" /db_xref="PDB:2W1R" /db_xref="PDB:2W1T" /db_xref="SubtiList:BG10119" /db_xref="UniProtKB/Swiss-Prot:P37554" /translation="MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEV ILKKYSPISELGDFAKEYADALYDSLGHSVLICDRDVYIAVSGSSKKDYLNKSISEML ERTMDQRSSVLESDAKSVQLVNGIDEDMNSYTVGPIVANGDPIGAVVIFSKDQTMGEV EHKAVETAAGFLARQMEQ*" /label="spoVT CDS" gene 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /label="spoVT gene" downshifts 64230 /Source="Nicolas_upshifts" /id="D27" /incds=0 /nref=236 /ntot=260 /MaxReadThrough="1.92082" /MaxDrop="6.20706" /score="-2.69593259" /energy="-11.6" /TU="NA" /idTUdmin="U49" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 64326..64345 /Source="Nicolas_upshift_promotors" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 64337 /Source="Nicolas_upshifts" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_387938.1" /db_xref="EnsemblGenomes-Gn:BSU00570" /db_xref="EnsemblGenomes-Tr:CAB11833" /db_xref="GOA:P37555" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10120" /db_xref="UniProtKB/Swiss-Prot:P37555" /translation="MDDSIGVKRHWIWQGAFVLILAGVITKILSAVYRVPFQNIVGDV GFYIYQQVYPFLGIAVMLSTSGFPVIISKLMNDYSEKNHHTILKISALFLSLIGILLF LCLYLGAVPIALFMGDSHLAVLIQVAAYAFLLFPFVALLRGGFQGRHEMLPSALSQMT EQFLRVAVLLGLSFWLVKKGASLYTAGAAAASGSLAGSLVALIILGFFWFKTKRDNQT DRQNENVITTKELTKKLLLYSVTICVSSLLLLFIQLVDALNLYALLSGGEASEEAKCL KGIYDRGQPLLQLGSVFAVSIATSLVPYISMAVKNKELKIMKEKITSSLKLCLVLGTG ASAGLICILKPVNIMLFQNGEGTGALQVFSCSILFASLAVTAAAVLQGAGYTVFPAIA VGAGVAVKWVLNTLLVPRYGIEGASLATAASFAAVAGLNLYQLRQKEWLDKLRGVLIP IIGSALLMSAVLLAYTRLWTFLFPATGRGAAVIESLSAVAIGGAVFIYCMMRLGIFTD EELNSVPFGSKLSKFMRRREQNGG*" /label="yabM CDS" gene 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /label="yabM gene" promotor_-35 65877..65884 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-35" promotor_-10 65899..65918 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-10" upshifts 65913 /Source="Nicolas_upshifts" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="upshifts" CDS 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11178267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fusion methylase and nucleotide pyrophosphohydrolase" /protein_id="NP_387939.1" /db_xref="EnsemblGenomes-Gn:BSU00580" /db_xref="EnsemblGenomes-Tr:CAB11834" /db_xref="GOA:P37556" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011551" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR024180" /db_xref="InterPro:IPR035013" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10121" /db_xref="UniProtKB/Swiss-Prot:P37556" /translation="MAGKITVVGLGAGDMDQLTIGIHKLLTKADTLYVRTKDHPLIEE LEKETKNIRFFDDIYEKHDQFEAVYEEIADILFEAARREDVVYAVPGHPFVAEKTVQL LTERQEKENVQVKVAGGQSFLDATFNVLQIDPIEGFQFVDAGTLSADELELRHHLIIC QVYDQMTASEVKLTLMEKLPDDYEVVIVTAAGSRGEEIRTVPLFELDRNVALNNLTSV YIPPIKEEKLLYHEFSTFRSIIRELRGPNGCPWDKKQTHQSLKQYMIEECYELLEAID EEDTDHMIEELGDVLLQVLLHAQIGEDEGYFTIDDVIKGISEKMVRRHPHVFKDVKVQ DENDVLANWEDIKKAEKNTSESSLLDSVPKTLPALSKAAKLQKKAAKVGFDWEDVSDI WEKVSEEMKEFSSEVSEAPHEHNLKAEFGDILFALVNVARFYKIEPEEALTMTNDKFR RRFSYIEETAKEEGVELADMSLEDMDKLWNEAKETERRS*" /label="yabN CDS" gene 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /label="yabN gene" promotor_-35 66637..66644 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-35" promotor_-10 66658..66676 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-10" upshifts 66672 /Source="Nicolas_upshifts" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="upshifts" promotor_no_box complement(67060..67160) /Source="Nicolas_upshift_promotors" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(67100) /Source="Nicolas_upshifts" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10675343, 10675344, 19013177; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal RNA binding protein involved in 50S recycling; heat shock protein" /protein_id="NP_387940.1" /db_xref="EnsemblGenomes-Gn:BSU00590" /db_xref="EnsemblGenomes-Tr:CAB11835" /db_xref="GOA:P37557" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR025490" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10122" /db_xref="UniProtKB/Swiss-Prot:P37557" /translation="MRLDKFLKVSRLIKRRTLAKEVADQGRISINGNQAKASSDVKPG DELTVRFGQKLVTVQVNELKDTTKKEEAANMYTILKEEKLGE*" /label="hslR CDS" gene 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /label="hslR gene" promotor_-35 67733..67738 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 67754..67772 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 67772 /Source="Nicolas_upshifts" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(67804) /Source="Nicolas_upshifts" /id="D28" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="1.93659" /MaxDrop="3.17193" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=3014 /isTUend="FALSE" /label="downshifts" CDS 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15231775, 21904870, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15231775, 21904870, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore protein involved in the shaping of the spore coat" /protein_id="NP_387941.1" /db_xref="EnsemblGenomes-Gn:BSU00600" /db_xref="EnsemblGenomes-Tr:CAB11836" /db_xref="GOA:P37558" /db_xref="InterPro:IPR012504" /db_xref="InterPro:IPR022476" /db_xref="SubtiList:BG10123" /db_xref="UniProtKB/Swiss-Prot:P37558" /translation="MNSYYDQKGSSSVPEQHDVTMKGRKHLDISGVKHVESFDNEEFL LETVMGMLSVRGQNLQMKNLDVEKGIVSIKGRVFDLVYLDEQQGDKAKGFFSKLFK*" /label="spcP CDS" gene 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /label="spcP gene" CDS 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein of the forespore" /protein_id="NP_387942.1" /db_xref="EnsemblGenomes-Gn:BSU00610" /db_xref="EnsemblGenomes-Tr:CAB11837" /db_xref="GOA:P37559" /db_xref="InterPro:IPR014242" /db_xref="InterPro:IPR019074" /db_xref="SubtiList:BG10124" /db_xref="UniProtKB/Swiss-Prot:P37559" /translation="MTLTTQFYTMLAMSGMGLWLGASLDTYRLFVIRAKTARWLLFIH DILFWIMQGLLFFYVLLHVNEGEFRIYIFLAVLLGVATYQSLCKRIYIKILKFVIYLV VSVYQFFKKLIQHVLFRPIVWTCGAIIWLAAFLFKKTYSLIGFLLLCLYKIVMVLCFP IRFIAKQCLKLLPVKMRLTFRRYFEKGAGFLKKKKKLLITIRTTITRFLKR*" /label="spcQ CDS" gene 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /label="spcQ gene" promotor_-35 68611..68620 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68633..68648 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68635 /Source="Nicolas_upshifts" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 68667..68675 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68686..68704 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68696 /Source="Nicolas_upshifts" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_387943.1" /db_xref="EnsemblGenomes-Gn:BSU00620" /db_xref="EnsemblGenomes-Tr:CAB11838" /db_xref="GOA:P37471" /db_xref="InterPro:IPR007060" /db_xref="SubtiList:BG10125" /db_xref="UniProtKB/Swiss-Prot:P37471" /translation="MNFSRERTITEIQNDYKEQVERQNQLKKRRRKGLYRRLTVFGAL VFLTAIVLASSVWSQTSSLSAKEEKKEQLEKELKSLKTKQTDLKEEISKLKDEDYVTE LARRDLFMSGDGEIIFNVEKKSK*" /label="divIC CDS" gene 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /label="divIC gene" CDS 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 15066026, 16014871, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; polyribonucleotide nucleotidyltransferase or phosphorylase" /protein_id="NP_387944.1" /db_xref="EnsemblGenomes-Gn:BSU00630" /db_xref="EnsemblGenomes-Tr:CAB11839" /db_xref="GOA:P37560" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG10126" /db_xref="UniProtKB/Swiss-Prot:P37560" /translation="MSIEVGSKLQGKITGITNFGAFVELPGGSTGLVHISEVADNYVK DINDHLKVGDQVEVKVINVEKDGKIGLSIKKAKDRPQARPRNDFRPKESFEQKMNKFL KDSEDRLSSLKRNTESKRGGRGARRG*" /label="yabR CDS" gene 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /label="yabR gene" downshifts 69597 /Source="Nicolas_upshifts" /id="D29" /incds=0 /nref=247 /ntot=274 /MaxReadThrough="3.67278" /MaxDrop="8.3221" /score="23.2738869" /energy="-12.5" /TU="U58" /idTUdmin="U53" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 69711..69718 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 69732..69751 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 69747 /Source="Nicolas_upshifts" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="upshifts" tRNA 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="methionine transfer RNA (CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Met1 tRNA" gene 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /label="trnSL-Met1 gene" tRNA 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="glutamate transfer RNA (UUC); Evidence 2a: Functionfrom experimental evidences in other organisms; Producttype n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu1 tRNA" gene 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /label="trnSL-Glu1 gene" downshifts 69928 /Source="Nicolas_upshifts" /id="D30" /incds=0 /nref=2 /ntot=58 /MaxReadThrough="4.83761" /MaxDrop="5.55326" /score="25.2769629" /energy="-10.8" /TU="U58,U60" /idTUdmin="U58" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 69973..70084 /Source="Nicolas_S_feature" /locus_tag="new_70382_70493" /HighExp="Cold, G180, C30, G135, G150, Oxctl, Paraq, H2O2, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S36" misc_feature 70080..70099 /Source="Nicolas_upshift_promotors" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 70086 /Source="Nicolas_upshifts" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="upshifts" CDS 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /EC_number="3.1.3.16" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10747015, 12180929, 15126482, 15866939, 15978076, 28358838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10747015, 12180929, 15126482, 15866939, 15978076, 28358838; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="SpoIIAA-phosphate serine phosphatase" /protein_id="NP_387945.1" /db_xref="EnsemblGenomes-Gn:BSU00640" /db_xref="EnsemblGenomes-Tr:CAB11840" /db_xref="GOA:P37475" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014221" /db_xref="InterPro:IPR036457" /db_xref="PDB:3T91" /db_xref="PDB:3T9Q" /db_xref="PDB:5UCG" /db_xref="SubtiList:BG10127" /db_xref="UniProtKB/Swiss-Prot:P37475" /translation="MEKAERRVNGPMAGQALEKLQSFFNRGTKLVTHHLHSLFFYKGF IYVVIGFLLGRAFILSEVLPFALPFFGAMLLIRRDKAFYAVLAVLAGALTISPKHSLL ILAALLAFFVFSKVAAFITDDRVKALPIVVFFSMAAARAGFVYAQNGVFTTYDYVMAI VEAGLSFILTLIFLQSLPIFTVKKVKQSLKIEEIICFMILIASVLTGLAGLSYQGMQA EHILARYVVLSFSFIGGASIGCTVGVVTGLILGLANIGNLYQMSLLAFSGLLGGLLKE GKKAGAAIGLIVGSLLISLYGEGSAGLMTTLYESLIAVCLFLLTPQSITRKVARYIPG TVEHLQEQQQYARKIRDVTAQKVDQFSNVFHALSESFATFYQASDEQTDDSEVDLFLS KITEHSCQTCYKKNRCWVQNFDKTYDLMKQVMLETEEKEYASNRRLKKEFQQYCSKSK QVEELIEDELAHHHAHLTLKKKVQDSRRLVAEQLLGVSEVMADFSREIKREREQHFLQ EEQIIEALQHFGIEIQHVEIYSLEQGNIDIEMTIPFSGHGESEKIIAPMLSDILEEQI LVKAEQHSPHPNGYSHVAFGSTKSYRVSTGAAHAAKGGGLVSGDSYSMMELGARKYAA AISDGMGNGARAHFESNETIKLLEKILESGIDEKIAIKTINSILSLRTTDEIYSTLDL SIIDLQDASCKFLKVGSTPSFIKRGDQVMKVQASNLPIGIINEFDVEVVSEQLKAGDL LIMMSDGIFEGPKHVENHDLWMKRKMKGLKTNDPQEIADLLMEEVIRTRSGQIEDDMT VVVVRIDHNTPKWASIPVPAIFQNKQEIS*" /label="spoIIE CDS" gene 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /label="spoIIE gene" downshifts 70170 /Source="Nicolas_upshifts" /id="D31" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="5.5737" /MaxDrop="3.93473" /score="25.2769629" /energy="-10.8" /TU="U60,U61" /idTUdmin="U58" /TUdmin=44 /isTUend="FALSE" /label="downshifts" S_feature complement(70781..71390) /Source="Nicolas_S_feature" /locus_tag="new_71190_71799_c" /HighExp="S8, S6, S4, S5, S3, S7, M9-stat, T5.0H, LoTm, Pyr" /AntisenseName="spoIIE" /AntisenseCor="0.685558251745638" /AntisenseRegPval="-38" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S37" downshifts complement(70807) /Source="Nicolas_upshifts" /id="D32" /incds=1 /nref=2 /ntot=11 /MaxReadThrough="2.2425" /MaxDrop="4.29972" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(71363..71381) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(71389) /Source="Nicolas_upshifts" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(71397..71402) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 71594..71600 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 71615..71633 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 71622 /Source="Nicolas_upshifts" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 72632..72635 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 72653..72670 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 72656 /Source="Nicolas_upshifts" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="upshifts" CDS 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387946.1" /db_xref="EnsemblGenomes-Gn:BSU00650" /db_xref="EnsemblGenomes-Tr:CAB11841" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG10128" /db_xref="UniProtKB/Swiss-Prot:P37561" /translation="MNNGHLNQILLITDGCSNHGEDPLAMAAFAKEQGITVNVIGIME ENQIDPEAMKEVEGIALAGGGVHQVVYASQLSQTVQMVTKKAMTQTLQGVVNQELKQI LGKNVEMEELSPEKRGEVMEVVDELGETVHLQVLVLVDTSASMAPKLPTVKEALIDLS VSLNSRIGNNEFAMCIFPGKKQEVELVLNWTPKLQSLSTLFAKLSTGGITPTGPAIRE ATLQFEKIRSRRGMLADDERRFDEFGM*" /label="yabS CDS" gene 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /label="yabS gene" CDS 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23634894, 24731262, 25278935" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23634894, 24731262, 25278935; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine-protein kinase" /protein_id="NP_387947.2" /db_xref="EnsemblGenomes-Gn:BSU00660" /db_xref="EnsemblGenomes-Tr:CAB11842" /db_xref="GOA:P37562" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG10129" /db_xref="UniProtKB/Swiss-Prot:P37562" /translation="MMNDALTSLACSLKPGTTIKGKWNGNTYTLRKQLGKGANGIVYL AETSDGHVALKVSDDSLSITSEVNVLKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSF YAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPP ARIRCIDVGGTTKEGRAIKEYTEFYDRGYWGYGTRKAEPSYDLFAVAMIMINSVHKKE FKKTNQPKEQLRSLIEGNPLLQKYKKALFSALNGDYQSADEMKKDMLDAGQKAAQRKQ PIKASPQPATRQRQQKPRQGKITKTRYTPKQKPAKSGGLFETTLIVISVLALYFAYII FFLI*" /label="prkT CDS" gene 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /label="prkT gene" promotor_-35 73948..73954 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-35" promotor_-10 73970..73988 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-10" upshifts 73976 /Source="Nicolas_upshifts" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="upshifts" promotor_-35 74446..74453 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 74467..74486 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 74477 /Source="Nicolas_upshifts" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /EC_number="6.3.4.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14527414, 16039592, 17005971, 22720735, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14527414, 16039592, 17005971, 22720735, 24001521; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(ile2) lysidine synthetase" /protein_id="NP_387948.1" /db_xref="EnsemblGenomes-Gn:BSU00670" /db_xref="EnsemblGenomes-Tr:CAB11843" /db_xref="GOA:P37563" /db_xref="InterPro:IPR011063" /db_xref="InterPro:IPR012094" /db_xref="InterPro:IPR012795" /db_xref="InterPro:IPR012796" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015262" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG10130" /db_xref="UniProtKB/Swiss-Prot:P37563" /translation="MKSVKDFLNKHNLTLKGATIIVGVSGGPDSMALLHALHTLCGRS ANVIAAHVDHRFRGAESEEDMRFVQAYCKAEQLVCETAQINVTAYAQEKGLNKQAAAR DCRYQFFEEIMSKHQADYLALAHHGDDQVETMLMKLAKGTLGTGLAGMQPVRRFGTGR IIRPFLTITKEEILHYCHENGLSYRTDESNAKDDYTRNRFRKTVLPFLKQESPDVHKR FQKVSEALTEDEQFLQSLTKDEMNKVITSQSNTSVEINSSQLLALPMPLQRRGVQLIL NYLYENVPSSFSAHHIQQFLDWAENGGPSGVLDFPKGLKVVKSYQTCLFTFEQWQCKN VPFEYQISGAADETAVLPNGYLIEARHYADSPEEHGNAVFITSEKKVRFPLTIRTRKA GDRIKLKGMNGSKKVKDIFIDKKLPLQERDNWPIVTDASGEIIWIPGLKKSIFEDLVI PNSDRIVLQYRQHEKCRGQAKS*" /label="tilS CDS" gene 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /label="tilS gene" promotor_-35 75315..75322 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 75337..75356 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 75340 /Source="Nicolas_upshifts" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" downshifts complement(75933) /Source="Nicolas_upshifts" /id="D33" /incds=0 /nref=2 /ntot=142 /MaxReadThrough="2.51342" /MaxDrop="2.96272" /score="12.3455896" /energy="-9.1" /TU="NA" /idTUdmin="U68" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /EC_number="2.4.2.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3110131, 6408059, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 6408059, 24001521; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hypoxanthine-guanine phosphoribosyltransferase" /protein_id="NP_387949.1" /db_xref="EnsemblGenomes-Gn:BSU00680" /db_xref="EnsemblGenomes-Tr:CAB11844" /db_xref="GOA:P37472" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005904" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10131" /db_xref="UniProtKB/Swiss-Prot:P37472" /translation="MMKHDIEKVLISEEEIQKKVKELGAELTSEYQDTFPLAIGVLKG ALPFMADLIKHIDTYLEMDFMDVSSYGNSTVSSGEVKIIKDLDTSVEGRDILIIEDII DSGLTLSYLVELFRYRKAKSIKIVTLLDKPSGRKADIKADFVGFEVPDAFVVGYGLDY AERYRNLPYIGVLKPAVYES*" /label="hprT CDS" gene 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /label="hprT gene" upshifts complement(76340) /Source="Nicolas_upshifts" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(76342..76346) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(76364..76367) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 76478..76574 /Source="Nicolas_S_feature" /locus_tag="new_76887_76983" /HighExp="Diami, H2O2, dia5, G135, dia15, G150, Paraq, C90, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.999, 1, 0.842" /TUlongSig="SigB, SigA" /TUlongPSig="1, 0.99" /label="S38" CDS 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /EC_number="3.4.24.-" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent cytoplasmic membrane protease" /protein_id="NP_387950.1" /db_xref="EnsemblGenomes-Gn:BSU00690" /db_xref="EnsemblGenomes-Tr:CAB11845" /db_xref="GOA:P37476" /db_xref="InterPro:IPR000642" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR003960" /db_xref="InterPro:IPR005936" /db_xref="InterPro:IPR011546" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR037219" /db_xref="SubtiList:BG10132" /db_xref="UniProtKB/Swiss-Prot:P37476" /translation="MNRVFRNTIFYLLILLVVIGVVSYFQTSNPKTENMSYSTFIKNL DDGKVDSVSVQPVRGVYEVKGQLKNYDKDQYFLTHVPEGKGADQIFNALKKTDVKVEP AQETSGWVTFLTTIIPFVIIFILFFFLLNQAQGGGSRVMNFGKSKAKLYTEEKKRVKF KDVAGADEEKQELVEVVEFLKDPRKFAELGARIPKGVLLVGPPGTGKTLLAKACAGEA GVPFFSISGSDFVEMFVGVGASRVRDLFENAKKNAPCLIFIDEIDAVGRQRGAGLGGG HDEREQTLNQLLVEMDGFSANEGIIIIAATNRADILDPALLRPGRFDRQITVDRPDVI GREAVLKVHARNKPLDETVNLKSIAMRTPGFSGADLENLLNEAALVAARQNKKKIDAR DIDEATDRVIAGPAKKSRVISKKERNIVAYHEGGHTVIGLVLDEADMVHKVTIVPRGQ AGGYAVMLPREDRYFQTKPELLDKIVGLLGGRVAEEIIFGEVSTGAHNDFQRATNIAR RMVTEFGMSEKLGPLQFGQSQGGQVFLGRDFNNEQNYSDQIAYEIDQEIQRIIKECYE RAKQILTENRDKLELIAQTLLKVETLDAEQIKHLIDHGTLPERNFSDDEKNDDVKVNI LTKTEEKKDDTKE*" /label="ftsH CDS" gene 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /label="ftsH gene" downshifts 78486 /Source="Nicolas_upshifts" /id="D34" /incds=0 /nref=187 /ntot=269 /MaxReadThrough="5.00908" /MaxDrop="8.91482" /score="38.4132386" /energy="-12.9" /TU="U66,U67" /idTUdmin="U64" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(78525..78529) /Source="Nicolas_upshift_promotors" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 78531..78616 /Source="Nicolas_S_feature" /locus_tag="new_78940_79025" /HighExp="H2O2, G180, G135, dia15, Paraq, G150, Oxctl, Diami, Cold, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S39" upshifts complement(78533) /Source="Nicolas_upshifts" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 78593..78600 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 78614..78633 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" S_feature 78618..78682 /Source="Nicolas_S_feature" /locus_tag="new_79027_79091" /HighExp="dia5, H2O2, dia15, Paraq, Diami, G180, LBGexp, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S40" upshifts 78618 /Source="Nicolas_upshifts" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15795230, 16905099, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15795230, 16905099, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase type III" /protein_id="NP_387951.2" /db_xref="EnsemblGenomes-Gn:BSU00700" /db_xref="EnsemblGenomes-Tr:CAB11846" /db_xref="GOA:P37564" /db_xref="InterPro:IPR004619" /db_xref="SubtiList:BG10133" /db_xref="UniProtKB/Swiss-Prot:P37564" /translation="MLLVIDVGNTNTVLGVYHDGKLEYHWRIETSRHKTEDEFGMILR SLFDHSGLMFEQIDGIIISSVVPPIMFALERMCTKYFHIEPQIVGPGMKTGLNIKYDN PKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEA LYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVI ATGGLAPLIANESDCIDIVDPFLTLKGLELIYERNRVGSV*" /label="coaX CDS" gene 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /label="coaX gene" CDS 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11323724, 15023991; Product type f: factor" /codon_start=1 /transl_table=11 /product="disulfide bond chaperone (heat shock protein HSP33)" /protein_id="NP_387952.1" /db_xref="EnsemblGenomes-Gn:BSU00710" /db_xref="EnsemblGenomes-Tr:CAB11847" /db_xref="GOA:P37565" /db_xref="InterPro:IPR000397" /db_xref="InterPro:IPR016153" /db_xref="InterPro:IPR016154" /db_xref="PDB:1VZY" /db_xref="SubtiList:BG10134" /db_xref="UniProtKB/Swiss-Prot:P37565" /translation="MDYLVKALAYDGKVRAYAARTTDMVNEGQRRHGTWPTASAALGR TMTASLMLGAMLKGDDKLTVKIEGGGPIGAIVADANAKGEVRAYVSNPQVHFDLNEQG KLDVRRAVGTNGTLSVVKDLGLREFFTGQVEIVSGELGDDFTYYLVSSEQVPSSVGVG VLVNPDNTILAAGGFIIQLMPGTDDETITKIEQRLSQVEPISKLIQKGLTPEEILEEV LGEKPEILETMPVRFHCPCSKERFETAILGLGKKEIQDMIEEDGQAEAVCHFCNEKYL FTKEELEGLRDQTTR*" /label="hslO CDS" gene 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /label="hslO gene" CDS 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 15856219; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein chaperone accessory lipoproteinfactor" /protein_id="NP_387953.1" /db_xref="EnsemblGenomes-Gn:BSU00720" /db_xref="EnsemblGenomes-Tr:CAB11848" /db_xref="GOA:P37566" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR027304" /db_xref="SubtiList:BG10135" /db_xref="UniProtKB/Swiss-Prot:P37566" /translation="MKSRTIWTIILGALLVCCIAVAYTLTKSQAGASSSGESIATIGG KSVTREEWLKEMEDQYGKSTLEDMINVRVVEQLAKKNKLKISKSEVDREFLLIKAVNN SFYEDEHTTEKEWKDQIRYNILLEDLLTRDIDISNKELESFYNKNKELYQFDDSYRIR HIVVKDEEEAREVLKELKGGSSFEAVAAERSTDRYTSPYGGDLGFVTEASDNIPSAYI EEAKTLKEDEWSQEPIKVSNGYAIIQLKEKLKARTFSFDEVKDQIRRQIAMDQLGDKA TVKTLWKEADVSWFYGEKSTK*" /label="yacD CDS" gene 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /label="yacD gene" promotor_-35 81016..81021 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 81038..81056 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 81039 /Source="Nicolas_upshifts" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 81285..81292 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 81307..81326 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 81314 /Source="Nicolas_upshifts" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /EC_number="2.5.1.47" /EC_number="4.4.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 15760717, 16267287, 16513748, 17056751, 18974048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15760717, 16267287, 16513748, 17056751, 18974048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cysteine synthase" /protein_id="NP_387954.1" /db_xref="EnsemblGenomes-Gn:BSU00730" /db_xref="EnsemblGenomes-Tr:CAB11849" /db_xref="GOA:P37887" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10136" /db_xref="UniProtKB/Swiss-Prot:P37887" /translation="MVRVANSITELIGNTPIVKLNRLADENSADVYLKLEYMNPGSSV KDRIGLAMIEAAEKEGKLKAGNTIIEPTSGNTGIGLAMVAAAKGLKAILVMPDTMSME RRNLLRAYGAELVLTPGAEGMKGAIKKAEELAEKHGYFVPQQFNNPSNPEIHRQTTGK EIVEQFGDDQLDAFVAGIGTGGTITGAGEVLKEAYPSIKIYAVEPSDSPVLSGGKPGP HKIQGIGAGFVPDILNTEVYDEIFPVKNEEAFEYARRAAREEGILGGISSGAAIYAAL QVAKKLGKGKKVLAIIPSNGERYLSTPLYQFD*" /label="cysK CDS" gene 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /label="cysK gene" downshifts 82281 /Source="Nicolas_upshifts" /id="D35" /incds=0 /nref=156 /ntot=259 /MaxReadThrough="5.90023" /MaxDrop="5.38596" /score="41.7897705" /energy="-11.4" /TU="U72" /idTUdmin="U70" /TUdmin=10 /isTUend="TRUE" /label="downshifts" promotor_-35 82335..82343 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 82357..82365 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 82359 /Source="Nicolas_upshifts" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 82387..82390 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 82405..82424 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 82415 /Source="Nicolas_upshifts" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /EC_number="2.6.1.85" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 9084182, 16605270, 17114263, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase (para-aminobenzoate synthase)" /protein_id="NP_387955.1" /db_xref="EnsemblGenomes-Gn:BSU00740" /db_xref="EnsemblGenomes-Tr:CAB11850" /db_xref="GOA:P28820" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10137" /db_xref="UniProtKB/Swiss-Prot:P28820" /translation="MAQRRPAGKKIPFQKDSFLQQFEKLAQSRKHHVLLESARGGRYS IAGLDPIATVKGKDGITTIKHGDEMLFKEGDPLRAFHSWFKTLETETNHEFPDFQGGA IGFLSYDYARYIENFKMLSLDDLETPDIYFLVFDDIAVYDHQEESLWLITHVNGSDQE TADVKLSELEQMWLTELPAVTSREMKPETAGSFAAPFTEDGFSQAVEKIKQYIASGDV FQVNLSIRQSQSLSVHPYQIYKTLREVNPSPYMAYLETPDFQIICGSPELLVSKKGKL LETRPIAGTRSRGKTNEEDEALANELIHNEKERAEHVMLVDLERNDLGRVSRYGSVRV NEFMAIEKYSHVMHIVSNVQGELQDGYDAVDIIHAVFPGGTITGAPKVRTMEIIEELE PTRRGLYTGSIGWFGYNHDLQFNIVIRTIYATGGQAFMQSGAGVVIDSVPKHEYKESF KKAFAMQRALELSEEETKIR*" /label="pabB CDS" gene 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /label="pabB gene" promotor_-35 83257..83259 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 83277..83295 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 83283 /Source="Nicolas_upshifts" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 83624..83631 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 83644..83663 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 83657 /Source="Nicolas_upshifts" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /EC_number="2.6.1.85" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098056, 16605270, 17114263, 24847778; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase; anthranilatesynthase (subunit II)" /protein_id="NP_387956.1" /db_xref="EnsemblGenomes-Gn:BSU00750" /db_xref="EnsemblGenomes-Tr:CAB11851" /db_xref="GOA:P28819" /db_xref="InterPro:IPR006221" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10138" /db_xref="UniProtKB/Swiss-Prot:P28819" /translation="MILMIDNYDSFTYNLVQYLGELGEELVVKRNDSITIDEIEELSP DFLMISPGPCSPDEAGISLEAIKHFAGKIPIFGVCLGHQSIAQVFGGDVVRAERLMHG KTSDIEHDGKTIFEGLKNPLVATRYHSLIVKPETLPSCFTVTAQTKEGEIMAIRHNDL PIEGVQFHPESIMTSFGKEMLRNFIETYRKEVIA*" /label="pabA CDS" gene 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /label="pabA gene" CDS 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /EC_number="4.1.3.38" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10876155, 1644759, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate pyruvate-lyase" /protein_id="NP_387957.1" /db_xref="EnsemblGenomes-Gn:BSU00760" /db_xref="EnsemblGenomes-Tr:CAB11852" /db_xref="GOA:P28821" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR017824" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10139" /db_xref="UniProtKB/Swiss-Prot:P28821" /translation="MIYVNGRYMEEKDAVLSPFDHGFLYGIGVFETFRLYEGCPFLLD WHIERLERALKDLQIEYTVSKHEILEMLDKLLKLNDIKDGNARVRLNISAGISDKGFV AQTYDKPTVLCFVNQLKPESLPLQKEGKVLSIRRNTPEGSFRLKSHHYLNNMYAKREI GNDPRVEGIFLTEDGAVAEGIISNVFWRKGRCIYTPSLDTGILDGVTRRFIIENAKDI GLELKTGRYELEALLTADEAWMTNSVLEIIPFTKIEEVNYGSQSGEATSALQLLYKKE IKNMIHEKGGRAWRSTQ*" /label="pabC CDS" gene 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /label="pabC gene" CDS 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /EC_number="2.5.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 11007651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydropteroate synthase" /protein_id="NP_387958.1" /db_xref="EnsemblGenomes-Gn:BSU00770" /db_xref="EnsemblGenomes-Tr:CAB11853" /db_xref="GOA:P28822" /db_xref="InterPro:IPR000489" /db_xref="InterPro:IPR006390" /db_xref="InterPro:IPR011005" /db_xref="SubtiList:BG10140" /db_xref="UniProtKB/Swiss-Prot:P28822" /translation="MAQHTIDQTQVIHTKPSALSYKEKTLVMGILNVTPDSFSDGGKY DSLDKALLHAKEMIDDGAHIIDIGGESTRPGAECVSEDEEMSRVIPVIERITKELGVP ISVDTYKASVADEAVKAGASIINDIWGAKHDPKMASVAAEHNVPIVLMHNRPERNYND LLPDMLSDLMESVKIAVEAGVDEKNIILDPGIGFAKTYHDNLAVMNKLEIFSGLGYPV LLATSRKRFIGRVLDLPPEERAEGTGATVCLGIQKGCDIVRVHDVKQIARMAKMMDAM LNKGGVHHG*" /label="folP CDS" gene 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /label="folP gene" CDS 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /EC_number="4.1.2.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16188473, 17176045, 17388809; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroneopterin aldolase" /protein_id="NP_387959.1" /db_xref="EnsemblGenomes-Gn:BSU00780" /db_xref="EnsemblGenomes-Tr:CAB11854" /db_xref="GOA:P28823" /db_xref="InterPro:IPR006156" /db_xref="InterPro:IPR006157" /db_xref="SubtiList:BG10141" /db_xref="UniProtKB/Swiss-Prot:P28823" /translation="MDKVYVEGMEFYGYHGVFTEENKLGQRFKVDLTAELDLSKAGQT DDLEQTINYAELYHVCKDIVEGEPVKLVETLAERIAGTVLGKFQPVQQCTVKVIKPDP PIPGHYKSVAIEITRKKS*" /label="folB CDS" gene 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /label="folB gene" CDS 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /EC_number="2.7.6.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17029412; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase" /protein_id="NP_387960.1" /db_xref="EnsemblGenomes-Gn:BSU00790" /db_xref="EnsemblGenomes-Tr:CAB11855" /db_xref="GOA:P29252" /db_xref="InterPro:IPR000550" /db_xref="InterPro:IPR035907" /db_xref="SubtiList:BG10142" /db_xref="UniProtKB/Swiss-Prot:P29252" /translation="MNNIAYIALGSNIGDRETYLRQAVALLHQHAAVTVTKVSSIYET DPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGRTREVRWGPRTADLDILLF NRENIETEQLIVPHPRMYERLFVLAPLAEICQQVEKEATSAETDQEGVRVWKQKSGVD EFVHSES*" /label="folK CDS" gene 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /label="folK gene" CDS 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_387961.1" /db_xref="EnsemblGenomes-Gn:BSU00800" /db_xref="EnsemblGenomes-Tr:CAB11856" /db_xref="GOA:O31417" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG12701" /db_xref="UniProtKB/Swiss-Prot:O31417" /translation="MEAEIWGRRIRAFRKLKGYTQEGFAKALGISVSILGEIERGNRL PSAAIIQDAADVLNISADELAPPEK*" /label="yazB CDS" gene 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /label="yazB gene" CDS 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 15698474, 26112661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase B" /protein_id="NP_387962.1" /db_xref="EnsemblGenomes-Gn:BSU00810" /db_xref="EnsemblGenomes-Tr:CAB11857" /db_xref="GOA:P37567" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR004652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG10143" /db_xref="UniProtKB/Swiss-Prot:P37567" /translation="MFKIGDIQLKNRVVLAPMAGVCNSAFRLTVKEFGAGLVCAEMVS DKAILYNNARTMGMLYIDEREKPLSLQIFGGKKETLVEAAKFVDQNTTADIIDINMGC PVPKITKCDAGAKWLLDPDKIYEMVSAVVDAVNKPVTVKMRMGWDEDHIFAVKNAQAV ERAGGKAVALHGRTRVQMYEGTANWDIIKEVKQSVSIPVIGNGDVKTPQDAKRMLDET GVDGVMIGRAALGNPWMIYRTVQYLETGKLKEEPQVREKMAVCKLHLDRLIDLKGENV AVREMRKHAAWYLKGVKGNANVRNEINHCETREEFVQLLDAFTVEVEAKELQNAKVG* " /label="dusB CDS" gene 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /label="dusB gene" S_feature complement(87641..89157) /Source="Nicolas_S_feature" /locus_tag="new_88050_89566_c" /HighExp="LoTm, C30, S6, S8, S5, S7, S3, S4, C90, G135" /AntisenseName="dusB" /AntisenseCor="-0.60218706634778196" /AntisenseRegPval="-27.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S41" S_feature 88227..88317 /Source="Nicolas_S_feature" /locus_tag="new_88636_88726" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, Diami, C30, LBGexp, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="SigA, SigI, SigA, SigEF, SigA, SigA, SigA" /TUlongPSig="0.621, 0.787, 1, 0.995, 1, 0.999, 1" /label="S42" CDS 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /EC_number="6.1.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14623972, 20649968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14623972, 20649968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lysyl-tRNA synthetase" /protein_id="NP_387963.1" /db_xref="EnsemblGenomes-Gn:BSU00820" /db_xref="EnsemblGenomes-Tr:CAB11858" /db_xref="GOA:P37477" /db_xref="InterPro:IPR002313" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018149" /db_xref="InterPro:IPR034762" /db_xref="SubtiList:BG10144" /db_xref="UniProtKB/Swiss-Prot:P37477" /translation="MSQEEHNHEELNDQLQVRRDKMNQLRDNGIDPFGARFERTHQSQ EVISAYQDLTKEELEEKAIEVTIAGRMMTKRGKGKAGFAHLQDLEGQIQIYVRKDSVG DDQYEIFKSSDLGDLIGVTGKVFKTNVGELSVKATSFELLTKALRPLPDKYHGLKDVE QRYRQRYLDLIVNPDSKHTFITRSKIIQAMRRYLDDHGYLEVETPTMHSIPGGASARP FITHHNALDIPLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIEL YEAYADYKDIMSLTENLVAHIAQEVLGTTTIQYGEEQIDLKPEWKRIHMVDAVKEATG VDFWEEVTVEQAREYAKEHEVEIKDSMTVGHIINEFFEQKIEETLIQPTFIYGHPVEI SPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQRERFEAQLKEREAGNDEAH LMDEDFVEALEYGMPPTGGLGIGIDRLVMLLTNAPSIRDVLLFPQMRQR*" /label="lysS CDS" gene 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /label="lysS gene" promotor_-10 complement(89141..89159) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(89157) /Source="Nicolas_upshifts" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(89175..89180) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 89798 /Source="Nicolas_upshifts" /id="D36" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="4.49559" /MaxDrop="4.89484" /score="4.33485487" /energy="-18.1" /TU="U76" /idTUdmin="U74" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 89893..89900 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 89909..90126 /Source="Nicolas_S_feature" /locus_tag="new_90318_90535" /HighExp="LBGstat, H2O2, Oxctl, Diami, dia15, Paraq, MG 25, Heat, MG 15, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 0.998, 1, 1, 0.999, 1" /label="S43" upshifts 89909 /Source="Nicolas_upshifts" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 89914..89933 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(89959) /Source="Nicolas_upshifts" /id="D37" /incds=0 /nref=3 /ntot=51 /MaxReadThrough="3.16217" /MaxDrop="5.0092" /score="18.6635354" /energy="-16.9" /TU="NA" /idTUdmin="U77" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" rRNA 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-16S rRNA" gene 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /label="rrnJ-16S gene" rRNA 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-23S rRNA" gene 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /label="rrnJ-23S gene" rRNA 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-5S rRNA" gene 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /label="rrnJ-5S gene" tRNA 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Val tRNA" gene 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /label="trnJ-Val gene" tRNA 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Thr tRNA" gene 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /label="trnJ-Thr gene" tRNA 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Lys tRNA" gene 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /label="trnJ-Lys gene" tRNA 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu1 tRNA" gene 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /label="trnJ-Leu1 gene" tRNA 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Gly tRNA" gene 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /label="trnJ-Gly gene" tRNA 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu2 tRNA" gene 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /label="trnJ-Leu2 gene" tRNA 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA(ACG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Arg tRNA" gene 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /label="trnJ-Arg gene" tRNA 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Pro(UGG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Pro tRNA" gene 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /label="trnJ-Pro gene" tRNA 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Ala tRNA" gene 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /label="trnJ-Ala gene" rRNA 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-16S rRNA" gene 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /label="rrnW-16S gene" rRNA 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-23S rRNA" gene 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /label="rrnW-23S gene" rRNA 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-5S rRNA" gene 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /label="rrnW-5S gene" S_feature 100803..100880 /Source="Nicolas_S_feature" /locus_tag="new_101212_101289" /HighExp="G135, G180, G150, Cold, Paraq, Oxctl, H2O2, C30, BMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S44" promotor_-35 100850..100853 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100869..100888 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100882 /Source="Nicolas_upshifts" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-35 100916..100922 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-35" promotor_-10 100936..100955 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-10" upshifts 100947 /Source="Nicolas_upshifts" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="upshifts" promotor_-35 100962..100969 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100983..101002 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100995 /Source="Nicolas_upshifts" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of class III stress genes" /protein_id="NP_387964.1" /db_xref="EnsemblGenomes-Gn:BSU00830" /db_xref="EnsemblGenomes-Tr:CAB11859" /db_xref="GOA:P37568" /db_xref="InterPro:IPR008463" /db_xref="SubtiList:BG10145" /db_xref="UniProtKB/Swiss-Prot:P37568" /translation="MGHNISDIIEQYLKRVLDQNGKEILEIKRSEIADKFQCVPSQIN YVINTRFTSERGYIVESKRGGGGYIRIIKIKMNNEVVLINNIISQINTHLSQAASDDI ILRLLEDKVISEREAKMMVSVMDRSVLHIDLPERDELRARMMKAMLTSLKLK*" /label="ctsR CDS" gene 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /label="ctsR gene" misc_feature complement(101151..101155) /Source="Nicolas_upshift_promotors" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(101157) /Source="Nicolas_upshifts" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 19189946, 24947607" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 19189946, 24947607; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of protein kinase McsB" /protein_id="NP_387965.1" /db_xref="EnsemblGenomes-Gn:BSU00840" /db_xref="EnsemblGenomes-Tr:CAB11860" /db_xref="GOA:P37569" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR025542" /db_xref="InterPro:IPR029037" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10146" /db_xref="UniProtKB/Swiss-Prot:P37569" /translation="MICQECHERPATFHFTKVVNGEKIEVHICEQCAKENSDSYGISA NQGFSIHNLLSGLLNMDSSFQNAGTQMFSHSEQISACPKCGMTFQQFRKIGRFGCSEC YKTFHSNITPILRKVHSGNTVHAGKIPKRIGGNLHVRRQIDMLKKELESLIHQEEFEN AAHVRDQIRLLEQSLKSTDSEEEQE*" /label="mcsA CDS" gene 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /label="mcsA gene" CDS 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /EC_number="2.7.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 17380125, 19189946, 21622759, 25610436, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 17380125, 19189946, 21622759, 25610436, 27749819; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein arginine kinase" /protein_id="NP_387966.1" /db_xref="EnsemblGenomes-Gn:BSU00850" /db_xref="EnsemblGenomes-Tr:CAB11861" /db_xref="GOA:P37570" /db_xref="InterPro:IPR000749" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR022414" /db_xref="InterPro:IPR022415" /db_xref="InterPro:IPR023660" /db_xref="SubtiList:BG10147" /db_xref="UniProtKB/Swiss-Prot:P37570" /translation="MSLKHFIQDALSSWMKQKGPESDIVLSSRIRLARNFEHIRFPTR YSNEEASSIIQQFEDQFSEQEIPGIGKFVLIRMNDAQPLEKRVLVEKHLISPNLTESP FGGCLLSENEEVSVMLNEEDHIRIQCLFPGFQLLEAMKAANQVDDWIEEKVDYAFNEQ RGYLTSCPTNVGTGLRASVMMHLPALVLTRQINRIIPAINQLGLVVRGIYGEGSEAVG NIFQISNQITLGKSEQDIVEDLNSVAAQLIEQERSAREAIYQTSKIELEDRVYRSYGV LSNCRMIESKETAKCLSDVRLGIDLGIIKGLSSNILNELMILTQPGFLQQYSGGALRP NERDIRRAALIRERLHLEMNGKRQEDESI*" /label="mcsB CDS" gene 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /label="mcsB gene" CDS 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354604, 15529410, 16525504, 26735940, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354604, 15529410, 16525504, 26735940, 27749819; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III stress response-related ATPase, AAA+ superfamily" /protein_id="NP_387967.1" /db_xref="EnsemblGenomes-Gn:BSU00860" /db_xref="EnsemblGenomes-Tr:CAB11862" /db_xref="GOA:P37571" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004176" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="InterPro:IPR036628" /db_xref="PDB:2K77" /db_xref="PDB:2Y1Q" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="PDB:5HBN" /db_xref="SubtiList:BG10148" /db_xref="UniProtKB/Swiss-Prot:P37571" /translation="MMFGRFTERAQKVLALAQEEALRLGHNNIGTEHILLGLVREGEG IAAKALQALGLGSEKIQKEVESLIGRGQEMSQTIHYTPRAKKVIELSMDEARKLGHSY VGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSAAGTNSNANT PTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIA EGLAQQIINNEVPEILRDKRVMTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIIL FIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEYRKYIEKDAALERRF QPIQVDQPSVDESIQILQGLRDRYEAHHRVSITDDAIEAAVKLSDRYISDRFLPDKAI DLIDEAGSKVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLR EQVEDTKKSWKEKQGQENSEVTVDDIAMVVSSWTGVPVSKIAQTETDKLLNMENILHS RVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESIFGDE ESMIRIDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHP DVFNILLQVLEDGRLTDSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDETQNH KDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHLTEIVSLMSDQLTKRLKEQDLS IELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIHKGQHIVLDVED GEFVVKTTAKTN*" /label="clpC CDS" gene 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /label="clpC gene" downshifts 105590 /Source="Nicolas_upshifts" /id="D38" /incds=0 /nref=57 /ntot=245 /MaxReadThrough="6.69446" /MaxDrop="4.4703" /score="-8.32149463" /energy="-11.7" /TU="U80,U81" /idTUdmin="U79" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /EC_number="2.1.1.63" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931349, 11810266, 15317759, 25616256; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair protein; 6-O-methylguanine-DNA methyltransferase" /protein_id="NP_387968.1" /db_xref="EnsemblGenomes-Gn:BSU00870" /db_xref="EnsemblGenomes-Tr:CAB11863" /db_xref="GOA:P37572" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004504" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10149" /db_xref="UniProtKB/Swiss-Prot:P37572" /translation="MAKTKSKFICQSCGYESPKWMGKCPGCGAWNTMVEEMIKKAPAN RRAAFSHSVQTVQKPSPITSIETSEEPRVKTQLGEFNRVLGGGVVKGSLVLIGGDPGI GKSTLLLQVSAQLSGSSNSVLYISGEESVKQTKLRADRLGINNPSLHVLSETDMEYIS SAIQEMNPSFVVVDSIQTVYQSDITSAPGSVSQVRECTAELMKIAKTKGIPIFIVGHV TKEGSIAGPRLLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEMGIFEMREEGLTE VLNPSEIFLEERSAGSAGSSITASMEGTRPILVEIQALISPTSFGNPRRMATGIDHNR VSLLMAVLEKRVGLLLQNQDAYLKVAGGVKLDEPAIDLAIVISIASSFRDTPPNPADC FIGEVGLTGEVRRVSRIEQRVKEAAKLGFKRMIIPAANLDGWTKPKGIEVIGVANVAE ALRTSLGG*" /label="radA CDS" gene 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /label="radA gene" promotor_-35 106142..106151 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 106164..106179 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 106167 /Source="Nicolas_upshifts" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase; DNA integrity scanning protein; cell cycle checkpoint DNA scanning protein" /protein_id="NP_387969.1" /db_xref="EnsemblGenomes-Gn:BSU00880" /db_xref="EnsemblGenomes-Tr:CAB11864" /db_xref="GOA:P37573" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR018906" /db_xref="InterPro:IPR023763" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG10150" /db_xref="UniProtKB/Swiss-Prot:P37573" /translation="MEKEKKGAKHELDLSSILQFVAPGTPLRAGMENVLRANTGGLIV VGYNDKVKEVVDGGFHINTAFSPAHLYELAKMDGAIILSDSGQKILYANTQLMPDATI SSSETGMRHRTAERVAKQTGCLVIAISERRNVITLYQENMKYTLKDIGFILTKANQAI QTLEKYKTILDKTINALNALEFEELVTFSDVLSVMHRYEMVLRIKNEINMYIKELGTE GHLIKLQVIELITDMEEEAALFIKDYVKEKIKDPFVLLKELQDMSSYDLLDDSIVYKL LGYPASTNLDDYVLPRGYRLLNKIPRLPMPIVENVVEAFGVLPRIIEASAEELDEVEG IGEVRAQKIKKGLKRLQEKHYLDRQL*" /label="disA CDS" gene 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /label="disA gene" S_feature 108150..108264 /Source="Nicolas_S_feature" /locus_tag="new_108559_108673" /HighExp="Etha, Salt, Heat, dia15, Diami, M9-stat, B60, T-0.40H, T-1.10H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.947" /label="S45" CDS 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26999498; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein possibly involved in RNA binding" /protein_id="NP_387970.1" /db_xref="EnsemblGenomes-Gn:BSU00890" /db_xref="EnsemblGenomes-Tr:CAB11865" /db_xref="GOA:Q06754" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG10151" /db_xref="UniProtKB/Swiss-Prot:Q06754" /translation="MLKRIVQAFFIIFGGVVGIFLIPELFVLLNIQDIPLITNAYTSA AIGAIIFFLISIWGTEYVVNWVKWIEDSLLKAPVPDLLFGSLGLVFGLIIAYLIVNVI PLDNIPYRIFSTIIPVFLAFFLGYLGFQVGFKKKDELISLFSISARMQKKKGTADEEH EVQDKKLKILDTSVIIDGRIADICQTGFLEGVIVIPQFVLEELQHIADSSDVLKRNRG RRGLDILNRIQKELDIEVEIYEGDFEDIQEVDSKLVKLAKLTSGVVVTNDFNLNKVCE LQKVAVLNINDLANAVKPVVLPGEEMNVQVIKDGKEHNQGVAYLDDGTMIVVEEGRNY IGKHIDVLVTSVLQTAAGRMIFAKPKLLEKAL*" /label="yacL CDS" gene 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /label="yacL gene" downshifts complement(109187) /Source="Nicolas_upshifts" /id="D39" /incds=1 /nref=1 /ntot=103 /MaxReadThrough="0.39171" /MaxDrop="2.87304" /score="-9.71423487" /energy="-11.8" /TU="NA" /idTUdmin="U82" /TUdmin="-8228" /isTUend="FALSE" /label="downshifts" CDS 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /EC_number="2.7.7.60" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, nonmevalonate isoprenoid pathway" /protein_id="NP_387971.1" /db_xref="EnsemblGenomes-Gn:BSU00900" /db_xref="EnsemblGenomes-Tr:CAB11866" /db_xref="GOA:Q06755" /db_xref="InterPro:IPR001228" /db_xref="InterPro:IPR018294" /db_xref="InterPro:IPR029044" /db_xref="InterPro:IPR034683" /db_xref="PDB:5DDT" /db_xref="PDB:5DDV" /db_xref="PDB:5HS2" /db_xref="SubtiList:BG10152" /db_xref="UniProtKB/Swiss-Prot:Q06755" /translation="MSYDVVIPAAGQGKRMKAGRNKLFIELKGDPVIIHTLRVFDSHR QCDKIILVINEQEREHFQQLLSDYPFQTSIELVAGGDERQHSVYKGLKAVKQEKIVLV HDGARPFIKHEQIDELIAEAEQTGAAILAVPVKDTIKRVQDLQVSETIERSSLWAVQT PQAFRLSLLMKAHAEAERKGFLGTDDASLVEQMEGGSVRVVEGSYTNIKLTTPDDLTS AEAIMESESGNKHV*" /label="ispD CDS" gene 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /label="ispD gene" CDS 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /EC_number="4.6.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9622350, 11997478, 12270818, 12682299, 17458547, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 11997478, 12270818, 12682299, 17458547, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase" /protein_id="NP_387972.1" /db_xref="EnsemblGenomes-Gn:BSU00910" /db_xref="EnsemblGenomes-Tr:CAB11867" /db_xref="GOA:Q06756" /db_xref="InterPro:IPR003526" /db_xref="InterPro:IPR020555" /db_xref="InterPro:IPR036571" /db_xref="PDB:5IWX" /db_xref="PDB:5IWY" /db_xref="SubtiList:BG10153" /db_xref="UniProtKB/Swiss-Prot:Q06756" /translation="MFRIGQGFDVHQLVEGRPLIIGGIEIPYEKGLLGHSDADVLLHT VADACLGAVGEGDIGKHFPDTDPEFKDADSFKLLQHVWGIVKQKGYVLGNIDCTIIAQ KPKMLPYIEDMRKRIAEGLEADVSQVNVKATTTEKLGFTGRAEGIAAQATVLIQKG*" /label="ispF CDS" gene 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /label="ispF gene" promotor_-35 110551..110558 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 110572..110591 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 110585 /Source="Nicolas_upshifts" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /EC_number="6.1.1.24" /EC_number="6.1.1.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA synthetase" /protein_id="NP_387973.1" /db_xref="EnsemblGenomes-Gn:BSU00920" /db_xref="EnsemblGenomes-Tr:CAB11868" /db_xref="GOA:P22250" /db_xref="InterPro:IPR000924" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR004527" /db_xref="InterPro:IPR008925" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020058" /db_xref="InterPro:IPR020061" /db_xref="InterPro:IPR020751" /db_xref="InterPro:IPR020752" /db_xref="InterPro:IPR033910" /db_xref="SubtiList:BG10154" /db_xref="UniProtKB/Swiss-Prot:P22250" /translation="MGNEVRVRYAPSPTGHLHIGNARTALFNYLFARNQGGKFIIRVE DTDKKRNIEGGEQSQLNYLKWLGIDWDESVDVGGEYGPYRQSERNDIYKVYYEELLEK GLAYKCYCTEEELEKEREEQIARGEMPRYSGKHRDLTQEEQEKFIAEGRKPSIRFRVP EGKVIAFNDIVKGEISFESDGIGDFVIVKKDGTPTYNFAVAIDDYLMKMTHVLRGEDH ISNTPKQIMIYQAFGWDIPQFGHMTLIVNESRKKLSKRDESIIQFIEQYKELGYLPEA LFNFIGLLGWSPVGEEELFTKEQFIEIFDVNRLSKSPALFDMHKLKWVNNQYVKKLDL DQVVELTLPHLQKAGKVGTELSAEEQEWVRKLISLYHEQLSYGAEIVELTDLFFTDEI EYNQEAKAVLEEEQVPEVLSTFAAKLEELEEFTPDNIKASIKAVQKETGHKGKKLFMP IRVAVTGQTHGPELPQSIELIGKETAIQRLKNI*" /label="gltX CDS" gene 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /label="gltX gene" promotor_-35 111567..111576 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-35" promotor_-10 111590..111609 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-10" upshifts 111590 /Source="Nicolas_upshifts" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="upshifts" S_feature 112090..112390 /Source="Nicolas_S_feature" /locus_tag="new_112499_112799" /HighExp="S6, S8, S7, Diami, C90, LBGexp, G135, H2O2, dia5, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17844199999999999" /TUshortSig="SigK, SigA, SigWXY" /TUshortPSig="1, 0.999, 1" /TUlongSig="SigA, SigB, SigA" /TUlongPSig="1, 1, 0.947" /label="S46" CDS 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /EC_number="2.3.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7510287, 10737181, 10939241, 17056751, 18974048, 25731080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7510287, 10737181, 10939241, 17056751, 18974048, 25731080; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine O-acetyltransferase" /protein_id="NP_387974.1" /db_xref="EnsemblGenomes-Gn:BSU00930" /db_xref="EnsemblGenomes-Tr:CAB11869" /db_xref="GOA:Q06750" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005881" /db_xref="InterPro:IPR010493" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="SubtiList:BG10155" /db_xref="UniProtKB/Swiss-Prot:Q06750" /translation="MFFRMLKEDIDTVFDQDPAARSYFEVILTYSGLHAIWAHRIAHA LYKRKFYFLARLISQVSRFFTGIEIHPGATIGRRFFIDHGMGVVIGETCEIGNNVTVF QGVTLGGTGKEKGKRHPTIKDDALIATGAKVLGSITVGEGSKIGAGSVVLHDVPDFST VVGIPGRVVVQNGKKVRRDLNHQDLPDPVADRFKSLEQQILELKAELEDRKERINQK* " /label="cysE CDS" gene 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /label="cysE gene" CDS 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /EC_number="6.1.1.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10024179, 10546897, 10931887, 12682299, 29079736" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024179, 10546897, 10931887, 12682299, 29079736; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual cysteinyl-tRNA synthetase; cysteine persulfide synthase" /protein_id="NP_387975.1" /db_xref="EnsemblGenomes-Gn:BSU00940" /db_xref="EnsemblGenomes-Tr:CAB11870" /db_xref="GOA:Q06752" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015273" /db_xref="InterPro:IPR015803" /db_xref="InterPro:IPR024909" /db_xref="InterPro:IPR032678" /db_xref="SubtiList:BG10156" /db_xref="UniProtKB/Swiss-Prot:Q06752" /translation="MTITLYNTLTRQKETFVPLEEGKVKMYVCGPTVYNYIHIGNARP AIVYDTVRNYLEYKGYDVQYVSNFTDVDDKLIKAANELGEDVPTISERFIKAYFEDVG ALGCRKADLHPRVMENMDAIIEFVDQLVKKGYAYESEGDVYFKTRAFEGYGKLSQQSI DELRSGARIRVGEKKEDALDFALWKAAKEGEISWDSPWGKGRPGWHIECSAMVKKYLG DQIDIHAGGQDLTFPHHENEIAQSEALTGKTFAKYWLHNGYINIDNEKMSKSLGNFVL VHDIIKQHDPQLLRFFMLSVHYRHPINYSEELLENTKSAFSRLKTAYSNLQHRLNSST NLTEDDDQWLEKVEEHRKAFEEEMDDDFNTANAISVLFDLAKHANYYLQKDHTADHVI TAFIEMFDRIVSVLGFSLGEQELLDQEIEDLIEKRNEARRNRDFALSDQIRDQLKSMN IILEDTAQGTRWKRGE*" /label="cysS CDS" gene 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /label="cysS gene" CDS 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 25634891, 27924926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 25634891, 27924926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease for 23S RNA maturation, mini-RNase III" /protein_id="NP_387976.1" /db_xref="EnsemblGenomes-Gn:BSU00950" /db_xref="EnsemblGenomes-Tr:CAB11871" /db_xref="GOA:O31418" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR008226" /db_xref="InterPro:IPR036389" /db_xref="PDB:4OUN" /db_xref="SubtiList:BG12702" /db_xref="UniProtKB/Swiss-Prot:O31418" /translation="MLEFDTIKDSKQLNGLALAYIGDAIFEVYVRHHLLKQGFTKPND LHKKSSRIVSAKSQAEILFFLQNQSFFTEEEEAVLKRGRNAKSGTTPKNTDVQTYRYS TAFEALLGYLFLEKKEERLSQLVAEAIQFGTSGRKTNESAT*" /label="mrnC CDS" gene 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /label="mrnC gene" CDS 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /EC_number="2.1.1.185" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11698387, 12377117, 16014871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (Gm2251)-methyltransferase" /protein_id="NP_387977.1" /db_xref="EnsemblGenomes-Gn:BSU00960" /db_xref="EnsemblGenomes-Tr:CAB11872" /db_xref="GOA:Q06753" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR004441" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG10157" /db_xref="UniProtKB/Swiss-Prot:Q06753" /translation="MSQQHDYVIGKNAVIETLKSDRKLYKLWMAENTVKGQAQQVIEL AKKQGITIQYVPRKKLDQMVTGQHQGVVAQVAAYEYAELDDLYKAAEEKNEQPFFLIL DELEDPHNLGSIMRTADAVGAHGIVIPKRRAVGLTTTVAKASTGAIEHIPVARVTNLA RTLEEMKERGIWVVGTDASAREDFRNMDGNMPLALVIGSEGKGMGRLVKEKCDFLIKL PMAGKVTSLNASVAAGLLMYEVYRKRNPVGE*" /label="rlmB CDS" gene 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /label="rlmB gene" CDS 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17114934, 23355615, 28363943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17114934, 23355615, 28363943; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-dependent mRNA endonuclease" /protein_id="NP_387978.1" /db_xref="EnsemblGenomes-Gn:BSU00970" /db_xref="EnsemblGenomes-Tr:CAB11873" /db_xref="InterPro:IPR010298" /db_xref="PDB:5MQ8" /db_xref="PDB:5MQ9" /db_xref="SubtiList:BG10158" /db_xref="UniProtKB/Swiss-Prot:P37574" /translation="MDILLVDGYNMIGAWPQLKDLKANSFEEARDVLIQKMAEYQSYT GNRVIVVFDAHLVKGLEKKQTNHRVEVIFTKENETADERIEKLAQALNNIATQIHVAT SDYTEQWAIFGQGALRKSARELLREVETIERRIERRVRKITSEKPAGKIALSEEVLKT FEKWRRGDLD*" /label="raeA CDS" gene 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /label="raeA gene" promotor_-35 116127..116134 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 116149..116168 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 116151 /Source="Nicolas_upshifts" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169614, 16339734, 25288929, 26712348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169614, 16339734, 25288929, 26712348; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-30 factor (sigma(H))" /protein_id="NP_387979.1" /db_xref="EnsemblGenomes-Gn:BSU00980" /db_xref="EnsemblGenomes-Tr:CAB11874" /db_xref="GOA:P17869" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014218" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR016371" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10159" /db_xref="UniProtKB/Swiss-Prot:P17869" /translation="MNLQNNKGKFNKEQFCQLEDEQVIEKVHVGDSDALDYLITKYRN FVRAKARSYFLIGADREDIVQEGMIGLYKSIRDFKEDKLTSFKAFAELCITRQIITAI KTATRQKHIPLNSYASLDKPIFDEESDRTLLDVISGAKTLNPEEMIINQEEFDDIEMK MGELLSDLERKVLVLYLDGRSYQEISDELNRHVKSIDNALQRVKRKLEKYLEIREISL *" /label="sigH CDS" gene 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /label="sigH gene" downshifts complement(116645) /Source="Nicolas_upshifts" /id="D40" /incds=1 /nref=1 /ntot=107 /MaxReadThrough="2.38622" /MaxDrop="2.50464" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=836 /isTUend="FALSE" /label="downshifts" S_feature 116848..116939 /Source="Nicolas_S_feature" /locus_tag="new_117257_117348" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, S1, S2, T5.0H, HiOs, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S47" CDS 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586115, 19648245, 23002217, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586115, 19648245, 23002217, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_387980.1" /db_xref="EnsemblGenomes-Gn:BSU00990" /db_xref="EnsemblGenomes-Tr:CAB11875" /db_xref="GOA:Q06798" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="SubtiList:BG10160" /db_xref="UniProtKB/Swiss-Prot:Q06798" /translation="MRKKITLACKTCGNRNYTTMKSSASAAERLEVKKYCSTCNSHTA HLETK*" /label="rpmGB CDS" gene 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /label="rpmGB gene" CDS 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11976315, 12682299, 16242710, 22304380, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11976315, 12682299, 16242710, 22304380, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_387981.1" /db_xref="EnsemblGenomes-Gn:BSU01000" /db_xref="EnsemblGenomes-Tr:CAB11876" /db_xref="GOA:Q06799" /db_xref="InterPro:IPR001901" /db_xref="InterPro:IPR005807" /db_xref="InterPro:IPR022943" /db_xref="SubtiList:BG10161" /db_xref="UniProtKB/Swiss-Prot:Q06799" /translation="MRIMKFFKDVGKEMKKVSWPKGKELTRYTITVISTVIFFVIFFA LLDTGISQLIRLIVE*" /label="secE CDS" gene 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /label="secE gene" S_feature 117303..117480 /Source="Nicolas_S_feature" /locus_tag="new_117712_117889" /HighExp="Cold, G180, G150, H2O2, LoTm, Oxctl, G135, Paraq, LBGexp, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S48" downshifts complement(117474) /Source="Nicolas_upshifts" /id="D41" /incds=0 /nref=37 /ntot=175 /MaxReadThrough="1.57397" /MaxDrop="4.03552" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11101662, 16014871, 16707701, 18852477, 26742846, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101662, 16014871, 16707701, 18852477, 26742846, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase elongation pause factor" /protein_id="NP_387982.1" /db_xref="EnsemblGenomes-Gn:BSU01010" /db_xref="EnsemblGenomes-Tr:CAB11877" /db_xref="GOA:Q06795" /db_xref="InterPro:IPR001062" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR006645" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015869" /db_xref="InterPro:IPR036735" /db_xref="SubtiList:BG10162" /db_xref="UniProtKB/Swiss-Prot:Q06795" /translation="MEKNWYVVHTYSGYENKVKANLEKRVESMGMQDKIFRVVVPEEE ETDIKNGKKKVVKKKVFPGYVLVEIVMTDDSWYVVRNTPGVTGFVGSAGSGSKPTPLL PGEAETILKRMGMDERKTDIDFELKETVKVIDGPFANFTGSIEEIDYDKSKVKVFVNM FGRETPVELEFTQIDKL*" /label="nusG CDS" gene 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /label="nusG gene" upshifts complement(117569) /Source="Nicolas_upshifts" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(117572..117576) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(117591..117596) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 118025..118032 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 118043..118181 /Source="Nicolas_S_feature" /locus_tag="new_118452_118590" /HighExp="T-1.40H, ferm, T-3.40H, T-5.40H, BI, B36, LoTm, SMM, T-2.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S49" upshifts 118043 /Source="Nicolas_upshifts" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 118046..118065 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11244072, 19653700, 20441189" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244072, 19653700, 20441189; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 (BL11)" /protein_id="NP_387983.2" /db_xref="EnsemblGenomes-Gn:BSU01020" /db_xref="EnsemblGenomes-Tr:CAB11878" /db_xref="GOA:Q06796" /db_xref="InterPro:IPR000911" /db_xref="InterPro:IPR006519" /db_xref="InterPro:IPR020783" /db_xref="InterPro:IPR020784" /db_xref="InterPro:IPR020785" /db_xref="InterPro:IPR036769" /db_xref="InterPro:IPR036796" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG10163" /db_xref="UniProtKB/Swiss-Prot:Q06796" /translation="MAKKVVKVVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNA RTADQAGLIIPVEISVYEDRSFTFITKTPPAAVLLKKAAGIESGSGEPNRNKVATVKR DKVREIAETKMPDLNAADVEAAMRMVEGTARSMGIVIED*" /label="rplK CDS" gene 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /label="rplK gene" S_feature 118608..118701 /Source="Nicolas_S_feature" /locus_tag="new_119017_119110" /HighExp="HPh, LPh, Lbexp, G180, LBGexp, G150, Heat, Cold, Fru, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S50" CDS 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16352840, 17981968, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L1 (BL1)" /protein_id="NP_387984.2" /db_xref="EnsemblGenomes-Gn:BSU01030" /db_xref="EnsemblGenomes-Tr:CAB11879" /db_xref="GOA:Q06797" /db_xref="InterPro:IPR002143" /db_xref="InterPro:IPR005878" /db_xref="InterPro:IPR016095" /db_xref="InterPro:IPR023673" /db_xref="InterPro:IPR023674" /db_xref="InterPro:IPR028364" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="SubtiList:BG10164" /db_xref="UniProtKB/Swiss-Prot:Q06797" /translation="MAKKGKKYVEAAKLVDRSKAYDVSEAVALVKKTNTAKFDATVEV AFRLGVDPRKNDQQIRGAVVLPNGTGKTQRVLVFAKGEKAKEAEAAGADFVGDTDYIN KIQQGWFDFDVIVATPDMMGEVGKIGRVLGPKGLMPNPKTGTVTFEVEKAIGEIKAGK VEYRVDKAGNIHVPIGKVSFEDEKLVENFTTMYDTILKAKPAAAKGVYVKNVAVTSTM GPGVKVDSSTFNVK*" /label="rplA CDS" gene 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /label="rplA gene" downshifts complement(119374) /Source="Nicolas_upshifts" /id="D42" /incds=0 /nref=3 /ntot=95 /MaxReadThrough="3.54108" /MaxDrop="3.36566" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U89" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /product="L10_leader" /experiment="publication(s) with functional evidences, PMID:26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26101249; Product type n: RNA" /label="ldlJ RNA" gene 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /label="ldlJ gene" upshifts complement(119462) /Source="Nicolas_upshifts" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(119465..119469) /Source="Nicolas_upshift_promotors" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 119518 /Source="Nicolas_upshifts" /id="D43" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="9.14839" /MaxDrop="2.9211" /score="20.0562348" /energy="-13.2" /TU="U88" /idTUdmin="U84" /TUdmin=1497 /isTUend="FALSE" /label="downshifts" CDS 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9810686, 11341315, 12682299, 18247578, 26101249, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9810686, 11341315, 12682299, 18247578, 26101249, 22720735; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L10 (BL5)" /protein_id="NP_387985.2" /db_xref="EnsemblGenomes-Gn:BSU01040" /db_xref="EnsemblGenomes-Tr:CAB11880" /db_xref="GOA:P42923" /db_xref="InterPro:IPR001790" /db_xref="InterPro:IPR002363" /db_xref="InterPro:IPR022973" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11220" /db_xref="UniProtKB/Swiss-Prot:P42923" /translation="MSSAIETKKVVVEEIASKLKESKSTIIVDYRGLNVSEVTELRKQ LREANVEFKVYKNTMTRRAVEQAELNGLNDFLTGPNAIAFSTEDVVAPAKVLNDFAKN HEALEIKAGVIEGKVSTVEEVKALAELPSREGLLSMLLSVLQAPVRNLALAAKAVAEQ KEEQGA*" /label="rplJ CDS" gene 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /label="rplJ gene" CDS 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 6771249, 8755892, 26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 6771249, 8755892, 26101249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L12 (BL9)" /protein_id="NP_387986.1" /db_xref="EnsemblGenomes-Gn:BSU01050" /db_xref="EnsemblGenomes-Tr:CAB11881" /db_xref="GOA:P02394" /db_xref="InterPro:IPR000206" /db_xref="InterPro:IPR008932" /db_xref="InterPro:IPR013823" /db_xref="InterPro:IPR014719" /db_xref="InterPro:IPR036235" /db_xref="SubtiList:BG10726" /db_xref="UniProtKB/Swiss-Prot:P02394" /translation="MALNIEEIIASVKEATVLELNDLVKAIEEEFGVTAAAPVAVAGG AAAGGAAEEQSEFDLILAGAGSQKIKVIKVVREITGLGLKEAKELVDNTPKPLKEGIA KEEAEELKAKLEEVGASVEVK*" /label="rplL CDS" gene 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /label="rplL gene" downshifts 120485 /Source="Nicolas_upshifts" /id="D44" /incds=1 /nref=5 /ntot=149 /MaxReadThrough="8.89506" /MaxDrop="4.0945" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2464 /isTUend="FALSE" /label="downshifts" downshifts 120558 /Source="Nicolas_upshifts" /id="D45" /incds=0 /nref=25 /ntot=157 /MaxReadThrough="7.44654" /MaxDrop="4.0033" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2537 /isTUend="FALSE" /label="downshifts" CDS 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /EC_number="2.1.1.174" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17010380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2G1835 methyltransferase" /protein_id="NP_387987.1" /db_xref="EnsemblGenomes-Gn:BSU01060" /db_xref="EnsemblGenomes-Tr:CAB11882" /db_xref="GOA:P37872" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10727" /db_xref="UniProtKB/Swiss-Prot:P37872" /translation="MSEHYYSEKPSVKSNKQTWSFRLRNKDFTFTSDSGVFSKKEVDF GSRLLIDSFEEPEVEGGILDVGCGYGPIGLSLASDFKDRTIHMIDVNERAVELSNENA EQNGITNVKIYQSDLFSNVDSAQTFASILTNPPIRAGKKVVHAIFEKSAEHLKASGEL WIVIQKKQGAPSAIEKLEELFDEVSVVQKKKGYYIIKAKKV*" /label="rlmG CDS" gene 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /label="rlmG gene" promotor_-35 121259..121263 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 121277..121509 /Source="Nicolas_S_feature" /locus_tag="new_121686_121918" /HighExp="G180, G150, H2O2, G135, Cold, T-5.40H, LoTm, T-3.40H, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S51" upshifts 121277 /Source="Nicolas_upshifts" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 121279..121298 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10049799, 10744988, 12455702, 12682299, 15060052, 28163698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10049799, 10744988, 12455702, 12682299, 15060052, 28163698; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta subunit)" /protein_id="NP_387988.2" /db_xref="EnsemblGenomes-Gn:BSU01070" /db_xref="EnsemblGenomes-Tr:CAB11883" /db_xref="GOA:P37870" /db_xref="InterPro:IPR007120" /db_xref="InterPro:IPR007121" /db_xref="InterPro:IPR007641" /db_xref="InterPro:IPR007642" /db_xref="InterPro:IPR007644" /db_xref="InterPro:IPR007645" /db_xref="InterPro:IPR010243" /db_xref="InterPro:IPR015712" /db_xref="InterPro:IPR019462" /db_xref="PDB:2LY7" /db_xref="SubtiList:BG10728" /db_xref="UniProtKB/Swiss-Prot:P37870" /translation="MTGQLVQYGRHRQRRSYARISEVLELPNLIEIQTSSYQWFLDEG LREMFQDISPIEDFTGNLSLEFIDYSLGEPKYPVEESKERDVTYSAPLRVKVRLINKE TGEVKDQDVFMGDFPIMTDTGTFIINGAERVIVSQLVRSPSVYFSGKVDKNGKKGFTA TVIPNRGAWLEYETDAKDVVYVRIDRTRKLPVTVLLRALGFGSDQEILDLIGENEYLR NTLDKDNTENSDKALLEIYERLRPGEPPTVENAKSLLDSRFFDPKRYDLANVGRYKIN KKLHIKNRLFNQRLAETLVDPETGEILAEKGQILDRRTLDKVLPYLENGIGFRKLYPN GGVVEDEVTLQSIKIFAPTDQEGEQVINVIGNAYIEEEIKNITPADIISSISYFFNLL HGVGDTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDTNTITPQQLIN IRPVIASIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGMEVRDVHY SHYGRMCPIETPEGPNIGLINSLSSYAKVNRFGFIETPYRRVDPETGKVTGRIDYLTA DEEDNYVVAQANARLDDEGAFIDDSIVARFRGENTVVSRNRVDYMDVSPKQVVSAATA CIPFLENDDSNRALMGANMQRQAVPLMQPEAPFVGTGMEYVSGKDSGAAVICKHPGIV ERVEAKNVWVRRYEEVDGQKVKGNLDKYSLLKFVRSNQGTCYNQRPIVSVGDEVVKGE ILADGPSMELGELALGRNVMVGFMTWDGYNYEDAIIMSERLVKDDVYTSIHIEEYESE ARDTKLGPEEITRDIPNVGEDALRNLDDRGIIRIGAEVKDGDLLVGKVTPKGVTELTA EERLLHAIFGEKAREVRDTSLRVPHGGGGIIHDVKVFNREDGDELPPGVNQLVRVYIV QKRKISEGDKMAGRHGNKGVISKILPEEDMPYLPDGTPIDIMLNPLGVPSRMNIGQVL ELHMGMAARYLGIHIASPVFDGAREEDVWETLEEAGMSRDAKTVLYDGRTGEPFDNRV SVGIMYMIKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGA AYTLQEILTVKSDDVVGRVKTYEAIVKGDNVPEPGVPESFKVLIKELQSLGMDVKILS GDEEEIEMRDLEDEEDAKQADGLALSGDEEPEETASADVERDVVTKE*" /label="rpoB CDS" gene 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /label="rpoB gene" promotor_-10 complement(123095..123114) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123098) /Source="Nicolas_upshifts" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123128..123137) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(123966..123970) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123971) /Source="Nicolas_upshifts" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123985..123991) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta' subunit)" /protein_id="NP_387989.2" /db_xref="EnsemblGenomes-Gn:BSU01080" /db_xref="EnsemblGenomes-Tr:CAB11884" /db_xref="GOA:P37871" /db_xref="InterPro:IPR000722" /db_xref="InterPro:IPR006592" /db_xref="InterPro:IPR007066" /db_xref="InterPro:IPR007080" /db_xref="InterPro:IPR007081" /db_xref="InterPro:IPR007083" /db_xref="InterPro:IPR012754" /db_xref="SubtiList:BG10729" /db_xref="UniProtKB/Swiss-Prot:P37871" /translation="MLDVNNFEYMNIGLASPDKIRSWSFGEVKKPETINYRTLKPEKD GLFCERIFGPTKDWECHCGKYKRVRYKGVVCDRCGVEVTRAKVRRERMGHIELAAPVS HIWYFKGIPSRMGLVLDMSPRALEEVIYFASYVVTDPANTPLEKKQLLSEKEYRAYLD KYGNKFQASMGAEAIHKLLQDIDLVKEVDMLKEELKTSQGQRRTRAIKRLEVLEAFRN SGNKPSWMILDVLPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGA PSIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGK RVDYSGRSVIVVGPHLKMYQCGLPKEMALELFKPFVMKELVEKGLAHNIKSAKRKIER VQPEVWDVLESVIKEHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVCTAYNADF DGDQMAVHVPLSAEAQAEARILMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLERAG AVGEGMVFKNTDEALLAYQNGYVHLHTRVAVAANSLKNVTFTEEQRSKLLITTVGKLV FNEILPESFPYMNEPTKSNIEEKTPDRFFLEKGADVKAVIAQQPINAPFKKGILGKII AEIFKRFHITETSKMLDRMKNLGFKYSTKAGITVGVSDIVVLDDKQEILEEAQSKVDN VMKQFRRGLITEEERYERVISIWSAAKDVIQGKLMKSLDELNPIYMMSDSGARGNASN FTQLAGMRGLMANPAGRIIELPIKSSFREGLTVLEYFISTHGARKGLADTALKTADSG YLTRRLVDVAQDVIIRETDCGTDRGILAKPLKEGTETIERLEERLIGRFARKQVKHPE TGEVLVNENELIDEDKALEIVEAGIEEVWIRSAFTCNTPHGVCKRCYGRNLATGSDVE VGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRIQELFEARNPKGQATIT EIDGTVVEINEVRDKQQEIVVQGAVETRSYTAPYNSRLKVAEGDKITRGQVLTEGSID PKELLKVTDLTTVQEYLLHEVQKVYRMQGVEIGDKHVEVMVRQMLRKVRVIDAGDTDV LPGTLLDIHQFTEANKKVLLEGNRPATGRPVLLGITKASLETDSFLSAASFQETTRVL TDAAIKGKRDELLGLKENVIIGKLVPAGTGMMKYRKVKPVSNVQPTDDMVPVE*" /label="rpoC CDS" gene 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /label="rpoC gene" downshifts complement(128217) /Source="Nicolas_upshifts" /id="D46" /incds=1 /nref=1 /ntot=76 /MaxReadThrough="3.40002" /MaxDrop="2.38911" /score="-2.05539956" /energy="-7.5" /TU="U93" /idTUdmin="U93" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" upshifts complement(128371) /Source="Nicolas_upshifts" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(128389..128390) /Source="Nicolas_upshift_promotors" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(128701) /Source="Nicolas_upshifts" /id="D47" /incds=0 /nref=98 /ntot=210 /MaxReadThrough="1.61828" /MaxDrop="4.90549" /score="-2.05539956" /energy="-7.5" /TU="NA" /idTUdmin="U95" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 128753..128874 /Source="Nicolas_S_feature" /locus_tag="new_129162_129283" /HighExp="LoTm, HiOs, S3, SMMPr, Heat, S1, BC, Glu, S4, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S52" promotor_-35 128856..128863 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" upshifts 128876 /Source="Nicolas_upshifts" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 128877..128896 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" misc_feature complement(128894..128898) /Source="Nicolas_upshift_promotors" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(128897) /Source="Nicolas_upshifts" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein; alternative ribosomal protein L7A" /protein_id="NP_387990.1" /db_xref="EnsemblGenomes-Gn:BSU01090" /db_xref="EnsemblGenomes-Tr:CAB11885" /db_xref="GOA:P46350" /db_xref="InterPro:IPR000948" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR023460" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7E" /db_xref="PDB:4LCK" /db_xref="PDB:4TZP" /db_xref="PDB:4TZV" /db_xref="PDB:4TZW" /db_xref="PDB:4TZZ" /db_xref="SubtiList:BG11365" /db_xref="UniProtKB/Swiss-Prot:P46350" /translation="MSYDKVSQAKSIIIGTKQTVKALKRGSVKEVVVAKDADPILTSS VVSLAEDQGISVSMVESMKKLGKACGIEVGAAAVAIIL*" /label="rulS CDS" gene 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /label="rulS gene" S_feature 129180..129292 /Source="Nicolas_S_feature" /locus_tag="new_129589_129701" /HighExp="T-3.40H, M/G, T-1.40H, T-5.40H, Salt, Mal, T-0.40H, G/S, M9-exp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S53" CDS 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11489846, 12682299, 16484214, 18252828, 19383706, 20007320" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489846, 12682299, 16484214, 18252828, 19383706, 20007320; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S12 (BS12)" /protein_id="NP_387991.2" /db_xref="EnsemblGenomes-Gn:BSU01100" /db_xref="EnsemblGenomes-Tr:CAB11886" /db_xref="GOA:P21472" /db_xref="InterPro:IPR005679" /db_xref="InterPro:IPR006032" /db_xref="InterPro:IPR012340" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19009" /db_xref="UniProtKB/Swiss-Prot:P21472" /translation="MPTINQLIRKGRVSKVENSKSPALNKGYNSFKKEHTNVSSPQKR GVCTRVGTMTPKKPNSALRKYARVRLTNGIEVTAYIPGIGHNLQEHSVVLIRGGRVKD LPGVRYHIVRGALDTAGVENRAQGRSKYGTKKPKAK*" /label="rpsL CDS" gene 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /label="rpsL gene" CDS 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 19653700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 19653700; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S7 (BS7)" /protein_id="NP_387992.2" /db_xref="EnsemblGenomes-Gn:BSU01110" /db_xref="EnsemblGenomes-Tr:CAB11887" /db_xref="GOA:P21469" /db_xref="InterPro:IPR000235" /db_xref="InterPro:IPR005717" /db_xref="InterPro:IPR020606" /db_xref="InterPro:IPR023798" /db_xref="InterPro:IPR036823" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19006" /db_xref="UniProtKB/Swiss-Prot:P21469" /translation="MPRKGPVAKRDVLPDPIYNSKLVSRLINKMMIDGKKGKSQTILY KSFDIIKERTGNDAMEVFEQALKNIMPVLEVKARRVGGANYQVPVEVRPERRTTLGLR WLVNYARLRGEKTMEERLANEILDAANNTGAAVKKREDTHKMAEANKAFAHYRW*" /label="rpsG CDS" gene 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /label="rpsG gene" CDS 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:815236, 815243, 1556067, 4629789, 19366171, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 815236, 815243, 1556067, 4629789, 19366171, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="elongation factor G" /protein_id="NP_387993.2" /db_xref="EnsemblGenomes-Gn:BSU01120" /db_xref="EnsemblGenomes-Tr:CAB11888" /db_xref="GOA:P80868" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004540" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005517" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009022" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035649" /db_xref="PDB:5VH6" /db_xref="SubtiList:BG11939" /db_xref="UniProtKB/Swiss-Prot:P80868" /translation="MAREFSLEKTRNIGIMAHIDAGKTTTTERILFYTGRIHKIGETH EGASQMDWMEQEQERGITITSAATTAQWKGYRVNIIDTPGHVDFTVEVERSLRVLDGA VAVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVGTLRDRLQANAH AIQLPIGAEDNFEGIIDLVENVAYFYEDDLGTRSDAKEIPEEYKEQAEELRNSLIEAV CELDEELMDKYLEGEEITIDELKAGIRKGTLNVEFYPVLVGSAFKNKGVQLVLDAVLD YLPAPTDVAAIKGTRPDTNEEIERHSSDEEPFSALAFKVMTDPYVGKLTFFRVYSGTL DSGSYVKNSTKGKRERVGRILQMHANSREEISTVYAGDIAAAVGLKDTTTGDTLCDEK DLVILESMEFPEPVIDVAIEPKSKADQDKMGIALAKLAEEDPTFRTQTNPETGQTIIS GMGELHLDIIVDRMKREFKVEANVGAPQVAYRETFRTGAKVEGKFVRQSGGRGQFGHV WIEFEPNEEGAGFEFENAIVGGVVPREYIPAVQAGLEDALENGVLAGFPLIDIKAKLF DGSYHDVDSNEMAFKVAASMALKNAVSKCNPVLLEPIMKVEVVIPEEYMGDIMGDITS RRGRVEGMEARGNAQVVRAMVPLAEMFGYATALRSNTQGRGTFTMHMDHYEEVPKSVA EEIIKKNKGE*" /label="fusA CDS" gene 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /label="fusA gene" S_feature 132354..132472 /Source="Nicolas_S_feature" /locus_tag="new_132763_132881" /HighExp="T-5.40H, T-4.40H, UNK1, SMM, HiTm, T-3.40H, T-2.40H, SMMPr, MG 90, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S54" CDS 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10774755, 12682299, 7706132, 20133608, 22938038, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10774755, 12682299, 7706132, 20133608, 22938038, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="elongation factor Tu" /protein_id="NP_387994.1" /db_xref="EnsemblGenomes-Gn:BSU01130" /db_xref="EnsemblGenomes-Tr:CAB11889" /db_xref="GOA:P33166" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004160" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004541" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR033720" /db_xref="SubtiList:BG11056" /db_xref="UniProtKB/Swiss-Prot:P33166" /translation="MAKEKFDRSKSHANIGTIGHVDHGKTTLTAAITTVLHKKSGKGT AMAYDQIDGAPEERERGITISTAHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDG AILVVSAADGPMPQTREHILLSKNVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLS EYDFPGDDVPVVKGSALKALEGDAEWEAKIFELMDAVDEYIPTPERDTEKPFMMPVED VFSITGRGTVATGRVERGQVKVGDEVEIIGLQEENKKTTVTGVEMFRKLLDYAEAGDN IGALLRGVSREEIQRGQVLAKPGTITPHSKFKAEVYVLSKEEGGRHTPFFSNYRPQFY FRTTDVTGIIHLPEGVEMVMPGDNTEMNVELISTIAIEEGTRFSIREGGRTVGSGVVS TITE*" /label="tufA CDS" gene 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /label="tufA gene" downshifts 133658 /Source="Nicolas_upshifts" /id="D48" /incds=0 /nref=258 /ntot=269 /MaxReadThrough="4.84568" /MaxDrop="8.56168" /score="39.3984056" /energy="-12.9" /TU="U88,U90,U94" /idTUdmin="U88" /TUdmin="-1081" /isTUend="FALSE" /label="downshifts" misc_feature complement(133689..133692) /Source="Nicolas_upshift_promotors" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(133693) /Source="Nicolas_upshifts" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 133719..133738 /Source="Nicolas_upshift_promotors" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 133727 /Source="Nicolas_upshifts" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /EC_number="3.4.11.5" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proline iminopeptidase" /protein_id="NP_387995.2" /db_xref="EnsemblGenomes-Gn:BSU01140" /db_xref="EnsemblGenomes-Tr:CAB11890" /db_xref="GOA:P70981" /db_xref="InterPro:IPR002410" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11988" /db_xref="UniProtKB/Swiss-Prot:P70981" /translation="MIPEKKSIAIMKELSIGNTKQMLMINGVDVKNPLLLFLHGGPGT PQIGYVRHYQKELEQYFTVVHWDQRGSGLSYSKRISHHSMTINHFIKDTIQVTQWLLA HFSKSKLYLAGHSWGSILALHVLQQRPDLFYTYYGISQVVNPQDEESTAYQHIREISE SKKASILSFLTRFIGAPPWKQDIQHLIYRFCVELTRGGFTHRHRQSLAVLFQMLTGNE YGVRNMHSFLNGLRFSKKHLTDELYRFNAFTSVPSIKVPCVFISGKHDLIVPAEISKQ YYQELEAPEKRWFQFENSAHTPHIEEPSLFANTLSRHARHHL*" /label="ybaC CDS" gene 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /label="ybaC gene" promotor_-35 134725..134732 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 134746..134765 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 134761..134954 /Source="Nicolas_S_feature" /locus_tag="new_135170_135363" /HighExp="T-1.40H, T-2.40H, T-1.10H, SMM, T-3.40H, T-4.40H, BI, BMM, H2O2, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S55" upshifts 134761 /Source="Nicolas_upshifts" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 27964882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 27964882; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S10 (BS13); transcription antitermination factor" /protein_id="NP_387996.1" /db_xref="EnsemblGenomes-Gn:BSU01150" /db_xref="EnsemblGenomes-Tr:CAB11891" /db_xref="GOA:P21471" /db_xref="InterPro:IPR001848" /db_xref="InterPro:IPR018268" /db_xref="InterPro:IPR027486" /db_xref="InterPro:IPR036838" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19008" /db_xref="UniProtKB/Swiss-Prot:P21471" /translation="MAKQKIRIRLKAYDHRILDQSAEKIVETAKRSGASVSGPIPLPT EKSVYTILRAVHKYKDSREQFEMRTHKRLIDIVNPTPQTVDALMRLDLPSGVDIEIKL *" /label="rpsJ CDS" gene 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /label="rpsJ gene" CDS 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 19154332, 23759864" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 19154332, 23759864; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L3 (BL3)" /protein_id="NP_387997.1" /db_xref="EnsemblGenomes-Gn:BSU01160" /db_xref="EnsemblGenomes-Tr:CAB11892" /db_xref="GOA:P42920" /db_xref="InterPro:IPR000597" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR019926" /db_xref="InterPro:IPR019927" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11218" /db_xref="UniProtKB/Swiss-Prot:P42920" /translation="MTKGILGRKIGMTQVFAENGDLIPVTVIEAAPNVVLQKKTAEND GYEAIQLGFDDKREKLSNKPEKGHVAKAETAPKRFVKELRGVEMDAYEVGQEVKVEIF SAGEIVDVTGVSKGKGFQGAIKRHGQSRGPMSHGSRYHRRPGSMGPVDPNRVFKGKLL PGRMGGEQITVQNLEIVKVDAERNLLLIKGNVPGAKKSLITVKSAVKSK*" /label="rplC CDS" gene 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /label="rplC gene" CDS 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10898684, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L4" /protein_id="NP_387998.1" /db_xref="EnsemblGenomes-Gn:BSU01170" /db_xref="EnsemblGenomes-Tr:CAB11893" /db_xref="GOA:P42921" /db_xref="InterPro:IPR002136" /db_xref="InterPro:IPR013005" /db_xref="InterPro:IPR023574" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11219" /db_xref="UniProtKB/Swiss-Prot:P42921" /translation="MPKVALYNQNGSTAGDIELNASVFGIEPNESVVFDAILMQRASL RQGTHKVKNRSEVRGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYSYKLP KKVRRLAIKSVLSSKVIDNNIIVLEDLTLDTAKTKEMAAILKGLSVEKKALIVTADAN EAVALSARNIPGVTVVEANGINVLDVVNHEKLLITKAAVEKVEEVLA*" /label="rplD CDS" gene 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /label="rplD gene" CDS 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L23" /protein_id="NP_387999.2" /db_xref="EnsemblGenomes-Gn:BSU01180" /db_xref="EnsemblGenomes-Tr:CAB11894" /db_xref="GOA:P42924" /db_xref="InterPro:IPR001014" /db_xref="InterPro:IPR012678" /db_xref="InterPro:IPR013025" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11221" /db_xref="UniProtKB/Swiss-Prot:P42924" /translation="MKDPRDVLKRPVITERSADLMTEKKYTFEVDVRANKTEVKDAVE SIFGVKVDKVNIMNYKGKSKRVGRYTGMTSRRRKAIVKLTADSKEIEIFEA*" /label="rplW CDS" gene 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /label="rplW gene" CDS 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23249812, 24637032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23249812, 24637032; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L2 (BL2)" /protein_id="NP_388000.2" /db_xref="EnsemblGenomes-Gn:BSU01190" /db_xref="EnsemblGenomes-Tr:CAB11895" /db_xref="GOA:P42919" /db_xref="InterPro:IPR002171" /db_xref="InterPro:IPR005880" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR014726" /db_xref="InterPro:IPR022666" /db_xref="InterPro:IPR022669" /db_xref="InterPro:IPR022671" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11217" /db_xref="UniProtKB/Swiss-Prot:P42919" /translation="MAIKKYKPTSNGRRGMTTSDFAEITTDKPEKSLLAPLHKKGGRN NQGKLTVRHQGGGHKRQYRVIDFKRDKDGIPGRVATVEYDPNRSANIALINYADGEKR YILAPKGIQVGTEIMSGPEADIKVGNALPLINIPVGTVVHNIELKPGKGGQLVRSAGT SAQVLGKEGKYVLVRLNSGEVRMILSACRASIGQVGNEQHELINIGKAGRSRWKGIRP TVRGSVMNPNDHPHGGGEGRAPIGRKSPMSPWGKPTLGFKTRKKKNKSDKFIVRRRKN K*" /label="rplB CDS" gene 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /label="rplB gene" downshifts complement(137038) /Source="Nicolas_upshifts" /id="D49" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="3.39972" /MaxDrop="4.09052" /score="-4.16840603" /energy="-12.8" /TU="NA" /idTUdmin="U99" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" CDS 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S19 (BS19)" /protein_id="NP_388001.1" /db_xref="EnsemblGenomes-Gn:BSU01200" /db_xref="EnsemblGenomes-Tr:CAB11896" /db_xref="GOA:P21476" /db_xref="InterPro:IPR002222" /db_xref="InterPro:IPR005732" /db_xref="InterPro:IPR020934" /db_xref="InterPro:IPR023575" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19011" /db_xref="UniProtKB/Swiss-Prot:P21476" /translation="MARSLKKGPFVDGHLMTKIEKLNETDKKQVVKTWSRRSTIFPQF IGHTIAVYDGRKHVPVFISEDMVGHKLGEFAPTRTYKGHASDDKKTRR*" /label="rpsS CDS" gene 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /label="rpsS gene" CDS 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7928988, 12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7928988, 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L22 (BL17)" /protein_id="NP_388002.1" /db_xref="EnsemblGenomes-Gn:BSU01210" /db_xref="EnsemblGenomes-Tr:CAB11897" /db_xref="GOA:P42060" /db_xref="InterPro:IPR001063" /db_xref="InterPro:IPR005727" /db_xref="InterPro:IPR018260" /db_xref="InterPro:IPR036394" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11078" /db_xref="UniProtKB/Swiss-Prot:P42060" /translation="MQAKAVARTVRIAPRKARLVMDLIRGKQVGEAVSILNLTPRAAS PIIEKVLKSAIANAEHNYEMDANNLVISQAFVDEGPTLKRFRPRAMGRASQINKRTSH ITIVVSEKKEG*" /label="rplV CDS" gene 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /label="rplV gene" CDS 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S3 (BS3)" /protein_id="NP_388003.2" /db_xref="EnsemblGenomes-Gn:BSU01220" /db_xref="EnsemblGenomes-Tr:CAB11898" /db_xref="GOA:P21465" /db_xref="InterPro:IPR001351" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR005704" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR018280" /db_xref="InterPro:IPR036419" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19005" /db_xref="UniProtKB/Swiss-Prot:P21465" /translation="MGQKVNPVGLRIGVIRDWESKWYAGKDYADFLHEDLKIREYISK RLSDASVSKVEIERAANRVNITIHTAKPGMVIGKGGSEVEALRKALNSLTGKRVHINI LEIKRADLDAQLVADNIARQLENRVSFRRAQKQQIQRTMRAGAQGVKTMVSGRLGGAD IARSEYYSEGTVPLHTLRADIDYATSEADTTYGKLGVKVWIYRGEVLPTKKKNEEGGK *" /label="rpsC CDS" gene 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /label="rpsC gene" downshifts complement(138446) /Source="Nicolas_upshifts" /id="D50" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="3.68388" /MaxDrop="2.1922" /score="-4.16840603" /energy="-12.8" /TU="U99" /idTUdmin="U99" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(138527..138531) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(138534) /Source="Nicolas_upshifts" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(138548..138550) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L16" /protein_id="NP_388004.1" /db_xref="EnsemblGenomes-Gn:BSU01230" /db_xref="EnsemblGenomes-Tr:CAB11899" /db_xref="GOA:P14577" /db_xref="InterPro:IPR000114" /db_xref="InterPro:IPR016180" /db_xref="InterPro:IPR020798" /db_xref="InterPro:IPR036920" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10755" /db_xref="UniProtKB/Swiss-Prot:P14577" /translation="MLLPKRVKYRREHRGKMRGRAKGGTEVHFGEFGIQALEASWITN RQIEAARIAMTRYMKRGGKVWIKIFPSKPYTAKPLEVRMGSGKGAPEGWVAVVKPGKV LFEISGVSEEVAREALRLASHKLPIKTKFVKREEIGGESNES*" /label="rplP CDS" gene 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /label="rplP gene" CDS 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L29" /protein_id="NP_388005.1" /db_xref="EnsemblGenomes-Gn:BSU01240" /db_xref="EnsemblGenomes-Tr:CAB11900" /db_xref="GOA:P12873" /db_xref="InterPro:IPR001854" /db_xref="InterPro:IPR018254" /db_xref="InterPro:IPR036049" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10756" /db_xref="UniProtKB/Swiss-Prot:P12873" /translation="MKANEIRDLTTAEIEQKVKSLKEELFNLRFQLATGQLENTARIR EVRKAIARMKTVIREREIAANK*" /label="rpmC CDS" gene 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /label="rpmC gene" CDS 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S17 (BS16)" /protein_id="NP_388006.1" /db_xref="EnsemblGenomes-Gn:BSU01250" /db_xref="EnsemblGenomes-Tr:CAB11901" /db_xref="GOA:P12874" /db_xref="InterPro:IPR000266" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019979" /db_xref="InterPro:IPR019984" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10757" /db_xref="UniProtKB/Swiss-Prot:P12874" /translation="MSERNQRKVYQGRVVSDKMDKTITVVVETYKKHTLYGKRVKYSK KFKAHDENNQAKIGDIVKIMETRPLSATKRFRLVEVVEEAVII*" /label="rpsQ CDS" gene 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /label="rpsQ gene" CDS 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 8805509, 12682299, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 8805509, 12682299, 22829778; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L14" /protein_id="NP_388007.1" /db_xref="EnsemblGenomes-Gn:BSU01260" /db_xref="EnsemblGenomes-Tr:CAB11902" /db_xref="GOA:P12875" /db_xref="InterPro:IPR000218" /db_xref="InterPro:IPR005745" /db_xref="InterPro:IPR019972" /db_xref="InterPro:IPR036853" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10758" /db_xref="UniProtKB/Swiss-Prot:P12875" /translation="MIQQETRLKVADNSGAREVLTIKVLGGSGRKTANIGDVIVCTVK QATPGGVVKKGEVVKAVIVRTKSGARRSDGSYISFDENACVIIRDDKSPRGTRIFGPV ARELRENNFMKIVSLAPEVI*" /label="rplNA CDS" gene 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /label="rplNA gene" CDS 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11278078, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11278078, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L24 (BL23)" /protein_id="NP_388008.1" /db_xref="EnsemblGenomes-Gn:BSU01270" /db_xref="EnsemblGenomes-Tr:CAB11903" /db_xref="GOA:P0CI78" /db_xref="InterPro:IPR003256" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR005825" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10759" /db_xref="UniProtKB/Swiss-Prot:P0CI78" /translation="MHVKKGDKVMVISGKDKGKQGTILAAFPKKDRVLVEGVNMVKKH SKPTQANPQGGISNQEAPIHVSNVMPLDPKTGEVTRVGYKVEDGKKVRVAKKSGQVLD K*" /label="rplX CDS" gene 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /label="rplX gene" CDS 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L5 (BL6)" /protein_id="NP_388009.1" /db_xref="EnsemblGenomes-Gn:BSU01280" /db_xref="EnsemblGenomes-Tr:CAB11904" /db_xref="GOA:P12877" /db_xref="InterPro:IPR002132" /db_xref="InterPro:IPR020929" /db_xref="InterPro:IPR020930" /db_xref="InterPro:IPR022803" /db_xref="InterPro:IPR031309" /db_xref="InterPro:IPR031310" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10760" /db_xref="UniProtKB/Swiss-Prot:P12877" /translation="MNRLKEKYNKEIAPALMTKFNYDSVMQVPKIEKIVINMGVGDAV QNAKAIDSAVEELTFIAGQKPVVTRAKKSIAGFRLREGMPIGAKVTLRGERMYDFLDK LISVSLPRVRDFRGVSKKSFDGRGNYTLGIKEQLIFPEIDYDKVTKVRGMDIVIVTTA NTDEEARELLTQVGMPFQK*" /label="rplE CDS" gene 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /label="rplE gene" CDS 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17163968, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17163968, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S14" /protein_id="NP_388010.1" /db_xref="EnsemblGenomes-Gn:BSU01290" /db_xref="EnsemblGenomes-Tr:CAB11905" /db_xref="GOA:P12878" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023053" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10761" /db_xref="UniProtKB/Swiss-Prot:P12878" /translation="MAKKSMIAKQQRTPKFKVQEYTRCERCGRPHSVIRKFKLCRICF RELAYKGQIPGVKKASW*" /label="rpsNA CDS" gene 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /label="rpsNA gene" CDS 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S8 (BS8)" /protein_id="NP_388011.2" /db_xref="EnsemblGenomes-Gn:BSU01300" /db_xref="EnsemblGenomes-Tr:CAB11906" /db_xref="GOA:P12879" /db_xref="InterPro:IPR000630" /db_xref="InterPro:IPR035987" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10762" /db_xref="UniProtKB/Swiss-Prot:P12879" /translation="MVMTDPIADMLTRIRNANMVRHEKLEIPASKLKREIAEILKREG FIRDVEFVEDSKQGIIRVFLKYGQNNERVITGLKRISKPGLRVYAKSNEVPRVLNGLG IAIISTSQGVLTDKEARAKQAGGEVLAYVW*" /label="rpsH CDS" gene 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /label="rpsH gene" downshifts complement(141966) /Source="Nicolas_upshifts" /id="D51" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="2.68318" /MaxDrop="2.55712" /score="5.40276403" /energy="-15.9" /TU="NA" /idTUdmin="U99" /TUdmin="-3586" /isTUend="FALSE" /label="downshifts" CDS 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 25330043; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L6 (BL8)" /protein_id="NP_388012.1" /db_xref="EnsemblGenomes-Gn:BSU01310" /db_xref="EnsemblGenomes-Tr:CAB11907" /db_xref="GOA:P46898" /db_xref="InterPro:IPR000702" /db_xref="InterPro:IPR002358" /db_xref="InterPro:IPR019906" /db_xref="InterPro:IPR020040" /db_xref="InterPro:IPR036789" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11408" /db_xref="UniProtKB/Swiss-Prot:P46898" /translation="MSRVGKKLLEIPSDVTVTLNDNNTVAVKGPKGELTRTFHPDMEI KVEDNVLTVARPSDQKEHRALHGTTRSLLGNMVEGVSKGFERGLELVGVGYRASKSGN KLVLNVGYSHPVEIVPEEGIEIEVPSQTKVVVKGTDKERVGAIAANIRAVRSPEPYKG KGIRYEGEVVRRKEGKSAK*" /label="rplF CDS" gene 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /label="rplF gene" CDS 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L18" /protein_id="NP_388013.2" /db_xref="EnsemblGenomes-Gn:BSU01320" /db_xref="EnsemblGenomes-Tr:CAB11908" /db_xref="GOA:P46899" /db_xref="InterPro:IPR004389" /db_xref="InterPro:IPR005484" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11409" /db_xref="UniProtKB/Swiss-Prot:P46899" /translation="MITKTSKNAARLKRHARVRAKLSGTAERPRLNVFRSNKHIYAQI IDDVNGVTLASASTLDKDLNVESTGDTSAATKVGELVAKRAAEKGISDVVFDRGGYLY HGRVKALADAAREAGLKF*" /label="rplR CDS" gene 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /label="rplR gene" CDS 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6211592, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6211592, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S5" /protein_id="NP_388014.1" /db_xref="EnsemblGenomes-Gn:BSU01330" /db_xref="EnsemblGenomes-Tr:CAB11909" /db_xref="GOA:P21467" /db_xref="InterPro:IPR000851" /db_xref="InterPro:IPR005324" /db_xref="InterPro:IPR005712" /db_xref="InterPro:IPR013810" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018192" /db_xref="InterPro:IPR020568" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10442" /db_xref="UniProtKB/Swiss-Prot:P21467" /translation="MRRIDPSKLELEERLVTVNRVAKVVKGGRRFRFAALVVVGDKNG HVGFGTGKAQEVPEAIRKAVEDAKKNLIEVPMVGTTIPHEIIGRFGAGNILLKPASEG TGVIAGGPVRAVLELAGVADILSKSLGSNTPINMIRATLQGLSELKRAEDVAKLRGKS VEELLG*" /label="rpsE CDS" gene 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /label="rpsE gene" CDS 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L30 (BL27)" /protein_id="NP_388015.1" /db_xref="EnsemblGenomes-Gn:BSU01340" /db_xref="EnsemblGenomes-Tr:CAB11910" /db_xref="GOA:P19947" /db_xref="InterPro:IPR005996" /db_xref="InterPro:IPR016082" /db_xref="InterPro:IPR018038" /db_xref="InterPro:IPR036919" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10443" /db_xref="UniProtKB/Swiss-Prot:P19947" /translation="MAKLEITLKRSVIGRPEDQRVTVRTLGLKKTNQTVVHEDNAAIR GMINKVSHLVSVKEQ*" /label="rpmD CDS" gene 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /label="rpmD gene" CDS 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15855514, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15855514, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L15" /protein_id="NP_388016.1" /db_xref="EnsemblGenomes-Gn:BSU01350" /db_xref="EnsemblGenomes-Tr:CAB11911" /db_xref="GOA:P19946" /db_xref="InterPro:IPR001196" /db_xref="InterPro:IPR005749" /db_xref="InterPro:IPR021131" /db_xref="InterPro:IPR030878" /db_xref="InterPro:IPR036227" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10444" /db_xref="UniProtKB/Swiss-Prot:P19946" /translation="MKLHELKPSEGSRKTRNRVGRGIGSGNGKTAGKGHKGQNARSGG GVRPGFEGGQMPLFQRLPKRGFTNINRKEYAVVNLDKLNGFAEGTEVTPELLLETGVI SKLNAGVKILGNGKLEKKLTVKANKFSASAKEAVEAAGGTAEVI*" /label="rplO CDS" gene 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /label="rplO gene" CDS 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478; Product type t: transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_388017.1" /db_xref="EnsemblGenomes-Gn:BSU01360" /db_xref="EnsemblGenomes-Tr:CAB11912" /db_xref="GOA:P16336" /db_xref="InterPro:IPR002208" /db_xref="InterPro:IPR023201" /db_xref="InterPro:IPR026593" /db_xref="InterPro:IPR030659" /db_xref="SubtiList:BG10445" /db_xref="UniProtKB/Swiss-Prot:P16336" /translation="MFKTISNFMRVSDIRNKIIFTLLMLIVFRIGAFIPVPYVNAEAL QAQSQMGVFDLLNTFGGGALYQFSIFAMGITPYITASIIIQLLQMDVVPKFTEWSKQG EVGRRKLAQFTRYFTIVLGFIQALGMSYGFNNLANGMLIEKSGVSTYLIIALVLTGGT AFLMWLGEQITSHGVGNGISIIIFAGIVSSIPKTIGQIYETQFVGSNDQLFIHIVKVA LLVIAILAVIVGVIFIQQAVRKIAIQYAKGTGRSPAGGGQSTHLPLKVNPAGVIPVIF AVAFLITPRTIASFFGTNDVTKWIQNNFDNTHPVGMAIYVALIIAFTYFYAFVQVNPE QMADNLKKQGGYIPGVRPGKMTQDRITSILYRLTFVGSIFLAVISILPIFFIQFAGLP QSAQIGGTSLLIVVGVALETMKQLESQLVKRNYRGFMKN*" /label="secY CDS" gene 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /label="secY gene" CDS 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /EC_number="2.7.4.3" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8061005, 8288548, 9056261, 9715904, 11106368, 16452168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8061005, 8288548, 9056261, 9715904, 11106368, 16452168; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate kinase" /protein_id="NP_388018.1" /db_xref="EnsemblGenomes-Gn:BSU01370" /db_xref="EnsemblGenomes-Tr:CAB11913" /db_xref="GOA:P16304" /db_xref="InterPro:IPR000850" /db_xref="InterPro:IPR006259" /db_xref="InterPro:IPR007862" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033690" /db_xref="PDB:1P3J" /db_xref="PDB:2EU8" /db_xref="PDB:2OO7" /db_xref="PDB:2ORI" /db_xref="PDB:2OSB" /db_xref="PDB:2P3S" /db_xref="PDB:2QAJ" /db_xref="PDB:3DKV" /db_xref="PDB:3DL0" /db_xref="PDB:4MKF" /db_xref="PDB:4MKG" /db_xref="PDB:4MKH" /db_xref="PDB:4QBF" /db_xref="PDB:4QBG" /db_xref="PDB:4TYP" /db_xref="PDB:4TYQ" /db_xref="SubtiList:BG10446" /db_xref="UniProtKB/Swiss-Prot:P16304" /translation="MNLVLMGLPGAGKGTQGERIVEDYGIPHISTGDMFRAAMKEETP LGLEAKSYIDKGELVPDEVTIGIVKERLGKDDCERGFLLDGFPRTVAQAEALEEILEE YGKPIDYVINIEVDKDVLMERLTGRRICSVCGTTYHLVFNPPKTPGICDKDGGELYQR ADDNEETVSKRLEVNMKQTQPLLDFYSEKGYLANVNGQQDIQDVYADVKDLLGGLKK* " /label="adk CDS" gene 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /label="adk gene" CDS 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16207374, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase" /protein_id="NP_388019.1" /db_xref="EnsemblGenomes-Gn:BSU01380" /db_xref="EnsemblGenomes-Tr:CAB11914" /db_xref="GOA:P19994" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG10447" /db_xref="UniProtKB/Swiss-Prot:P19994" /translation="MIICKTPRELGIMREAGRIVALTHEELKKHIKPGISTKELDQIA ERFIKKQGAIPSFKGYNGFRGSICVSVNEELVHGIPGSRVLKDGDIISIDIGAKLNGY HGDSAWTYPVGNISDDDKKLLEVTEESLYKGLQEAKPGERLSNISHAIQTYVENEQFS VVREYVGHGVGQDLHEDPQIPHYGPPNKGPRLKPGMVLAIEPMVNAGSRYVKTLADNW TVVTVDGKKCAHFEHTIAITETGFDILTRV*" /label="mapA CDS" gene 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /label="mapA gene" CDS 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17157877; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative ribosome binding protein" /protein_id="YP_003097669.1" /db_xref="EnsemblGenomes-Gn:BSU01389" /db_xref="EnsemblGenomes-Tr:CAX52539" /db_xref="UniProtKB/Swiss-Prot:C0H3S8" /translation="MIGQKAWVNIGKTEFILLLVVGILTIINVLTADGEKRTFHSPKK KNINHLTLYDCVSPEVQNSINETGRVTNFF*" /label="ybzG CDS" gene 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /label="ybzG gene" CDS 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9868784, 20477873, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-I" /protein_id="NP_388020.1" /db_xref="EnsemblGenomes-Gn:BSU01390" /db_xref="EnsemblGenomes-Tr:CAB11915" /db_xref="GOA:P20458" /db_xref="InterPro:IPR004368" /db_xref="InterPro:IPR006196" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11043" /db_xref="UniProtKB/Swiss-Prot:P20458" /translation="MAKDDVIEVEGTIVETLPNAMFKVELENGHTVLAHVSGKIRMHF IRILPGDKVTVELSPYDLTRGRITYRYK*" /label="infA CDS" gene 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /label="infA gene" CDS 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1783905, 23002217, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1783905, 23002217, 24335279; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L36 (ribosomal protein B)" /protein_id="NP_388021.1" /db_xref="EnsemblGenomes-Gn:BSU01400" /db_xref="EnsemblGenomes-Tr:CAB11916" /db_xref="GOA:P20278" /db_xref="InterPro:IPR000473" /db_xref="InterPro:IPR035977" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11042" /db_xref="UniProtKB/Swiss-Prot:P20278" /translation="MKVRPSVKPICEKCKVIRRKGKVMVICENPKHKQKQG*" /label="rpmJ CDS" gene 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /label="rpmJ gene" CDS 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S13" /protein_id="NP_388022.2" /db_xref="EnsemblGenomes-Gn:BSU01410" /db_xref="EnsemblGenomes-Tr:CAB11917" /db_xref="GOA:P20282" /db_xref="InterPro:IPR001892" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR018269" /db_xref="InterPro:IPR019980" /db_xref="InterPro:IPR027437" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10730" /db_xref="UniProtKB/Swiss-Prot:P20282" /translation="MARIAGVDIPRDKRVVISLTYIFGIGRTTAQQVLKEAGVSEDTR VRDLTEEELGKIRDIIDKLKVEGDLRREVSLNIKRLIEIGSYRGIRHRRGLPVRGQNS KNNARTRKGPRRTVANKKK*" /label="rpsM CDS" gene 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /label="rpsM gene" CDS 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217780, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217780, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S11 (BS11)" /protein_id="NP_388023.1" /db_xref="EnsemblGenomes-Gn:BSU01420" /db_xref="EnsemblGenomes-Tr:CAB11918" /db_xref="GOA:P04969" /db_xref="InterPro:IPR001971" /db_xref="InterPro:IPR018102" /db_xref="InterPro:IPR019981" /db_xref="InterPro:IPR036967" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10731" /db_xref="UniProtKB/Swiss-Prot:P04969" /translation="MAAARKSNTRKRRVKKNIESGIAHIRSTFNNTIVTITDTHGNAI SWSSAGALGFRGSRKSTPFAAQMAAETAAKGSIEHGLKTLEVTVKGPGSGREAAIRAL QAAGLEVTAIRDVTPVPHNGCRPPKRRRV*" /label="rpsK CDS" gene 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /label="rpsK gene" S_feature 148346..148521 /Source="Nicolas_S_feature" /locus_tag="new_148755_148930" /HighExp="G135, dia5, Lbexp, S0, aero, dia0, T-4.40H, G150, Paraq, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S56" CDS 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1484484, 6811591, 9594570, 10972808, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1484484, 6811591, 9594570, 10972808, 12682299, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (alpha subunit)" /protein_id="NP_388024.1" /db_xref="EnsemblGenomes-Gn:BSU01430" /db_xref="EnsemblGenomes-Tr:CAB11919" /db_xref="GOA:P20429" /db_xref="InterPro:IPR011260" /db_xref="InterPro:IPR011262" /db_xref="InterPro:IPR011263" /db_xref="InterPro:IPR011773" /db_xref="InterPro:IPR036603" /db_xref="InterPro:IPR036643" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG10732" /db_xref="UniProtKB/Swiss-Prot:P20429" /translation="MIEIEKPKIETVEISDDAKFGKFVVEPLERGYGTTLGNSLRRIL LSSLPGAAVTSIQIDGVLHEFSTIEGVVEDVTTIILHIKKLALKIYSDEEKTLEIDVQ GEGTVTAADITHDSDVEILNPDLHIATLGENASFRVRLTAQRGRGYTPADANKRDDQP IGVIPIDSIYTPVSRVSYQVENTRVGQVANYDKLTLDVWTDGSTGPKEAIALGSKILT EHLNIFVGLTDEAQHAEIMVEKEEDQKEKVLEMTIEELDLSVRSYNCLKRAGINTVQE LANKTEEDMMKVRNLGRKSLEEVKAKLEELGLGLRKDD*" /label="rpoA CDS" gene 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /label="rpoA gene" CDS 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6801428, 10717392, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6801428, 10717392, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L17 (BL15)" /protein_id="NP_388025.1" /db_xref="EnsemblGenomes-Gn:BSU01440" /db_xref="EnsemblGenomes-Tr:CAB11920" /db_xref="GOA:P20277" /db_xref="InterPro:IPR000456" /db_xref="InterPro:IPR036373" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11041" /db_xref="UniProtKB/Swiss-Prot:P20277" /translation="MSYRKLGRTSAQRKAMLRDLTTDLIINERIETTETRAKELRSVV EKMITLGKRGDLHARRQAAAYIRNEVANEENNQDALQKLFSDIATRYEERQGGYTRIM KLGPRRGDGAPMAIIELV*" /label="rplQ CDS" gene 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /label="rplQ gene" downshifts 149908 /Source="Nicolas_upshifts" /id="D52" /incds=0 /nref=171 /ntot=259 /MaxReadThrough="7.50771" /MaxDrop="5.4374" /score="2.32634618" /energy="-10.5" /TU="U98" /idTUdmin="U98" /TUdmin="-5577" /isTUend="FALSE" /label="downshifts" S_feature 149953..150033 /Source="Nicolas_S_feature" /locus_tag="new_150362_150442" /HighExp="Cold, G180, G135, G150, H2O2, S0, C30, Oxctl, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S57" CDS 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388026.2" /db_xref="EnsemblGenomes-Gn:BSU01450" /db_xref="EnsemblGenomes-Tr:CAB11921" /db_xref="GOA:P40735" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030947" /db_xref="SubtiList:BG11067" /db_xref="UniProtKB/Swiss-Prot:P40735" /translation="MNQNQLISVEDIVFRYRKDAERRALDGVSLQVYEGEWLAIVGHN GSGKSTLARALNGLILPESGDIEVAGIQLTEESVWEVRKKIGMVFQNPDNQFVGTTVR DDVAFGLENNGVPREEMIERVDWAVKQVNMQDFLDQEPHHLSGGQKQRVAIAGVIAAR PDIIILDEATSMLDPIGREEVLETVRHLKEQGMATVISITHDLNEAAKADRIIVMNGG KKYAEGPPEEIFKLNKELVRIGLDLPFSFQLSQLLRENGLALEENHLTQEGLVKELWT LQSKM*" /label="ecfA CDS" gene 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /label="ecfA gene" CDS 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12110480, 21135102, 26052893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388027.1" /db_xref="EnsemblGenomes-Gn:BSU01460" /db_xref="EnsemblGenomes-Tr:CAB11922" /db_xref="GOA:P70970" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030946" /db_xref="SubtiList:BG11989" /db_xref="UniProtKB/Swiss-Prot:P70970" /translation="MKTPFERLALYDINASIKEGSYVAVIGHTGSGKSTLLQHLNGLL KPTKGQISLGSTVIQAGKKNKDLKKLRKKVGIVFQFPEHQLFEETVLKDISFGPMNFG VKKEDAEQKAREMLQLVGLSEELLDRSPFELSGGQMRRVAIAGVLAMDPEVLVLDEPT AGLDPRGRKEIMDMFYELHQRGNLTTILVTHSMEDAAAYADEMIVMHKGTIQASGSPR DLFLKGEEMAGWGLDLPETIKFQRHLEAALGVRFNEPMLTIEDAAAEIRALFQGEKTL *" /label="ecfAB CDS" gene 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /label="ecfAB gene" CDS 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18931129, 21135102, 26052893; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the influx ECF transporters" /protein_id="NP_388028.2" /db_xref="EnsemblGenomes-Gn:BSU01470" /db_xref="EnsemblGenomes-Tr:CAB11923" /db_xref="GOA:P70972" /db_xref="InterPro:IPR003339" /db_xref="InterPro:IPR024919" /db_xref="SubtiList:BG11990" /db_xref="UniProtKB/Swiss-Prot:P70972" /translation="MMDSMIIGKYVPGTSLVHRLDPRTKLITIFLFVCIVFLANNVQT YALLGLFTIGVVSLTRVPFSFLMKGLKPIIWIVLFTFLLHILMTHEGPIIFQIGFFKV YEGGLVQGIFISLRFVYLILITTLLTLTTTPIEITDGMEQLLNPLKKLKLPVHELALM MSISLRFIPTLMEETDKIMKAQMARGVDFTSGPVKERVKAIVPLLVPLFVSAFKRAEE LAVAMEARGYQGGEGRTKYRKLVWTGKDTSVIVSLIVLAALLFFLRA*" /label="ecfT CDS" gene 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /label="ecfT gene" CDS 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /EC_number="5.4.99.12" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10529181, 15353568, 17114947, 17466622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine (38-40) synthase" /protein_id="NP_388029.2" /db_xref="EnsemblGenomes-Gn:BSU01480" /db_xref="EnsemblGenomes-Tr:CAB11924" /db_xref="GOA:P70973" /db_xref="InterPro:IPR001406" /db_xref="InterPro:IPR020095" /db_xref="InterPro:IPR020097" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG11992" /db_xref="UniProtKB/Swiss-Prot:P70973" /translation="MRLKCTISYDGHLFNGYQVQPGKRTVQDELEKALAVLHKSKDRI PVVSSGRTDSGVHAAGQVIHFDTPLSIPAERWPYALNALLPDDIAVKQAEIADDGFHA RFSAVKKEYRYFVYTEKHPDVFKRHYAYHFSYRLNVQDMREAAKHLIGTHDFTSFCAA KTEVQDKVRTIYELDWTETADGLQMRITGSGFLYNMVRIIAGTLLDAGIGKISPDEVK SMLEAKDREAAGRTAPGHGLYLWNVYYDN*" /label="truA CDS" gene 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /label="truA gene" S_feature complement(152630..153098) /Source="Nicolas_S_feature" /locus_tag="new_153039_153507_c" /HighExp="S6, S8, S7, C30, G135, BT, S5, C90, M/G, Pyr" /AntisenseName="truA" /AntisenseCor="-0.30232258010971202" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S58" promotor_-35 152763..152768 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 152783..152800 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 152802 /Source="Nicolas_upshifts" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(153098..153117) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(153120) /Source="Nicolas_upshifts" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(153130..153139) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 153291..153297 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 153312..153331 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 153316 /Source="Nicolas_upshifts" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /product="putative L13_leader" /note="Evidence 3: Putative function from multiple computational evidences; Product type n: RNA" /label="ldlM RNA" gene 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /label="ldlM gene" CDS 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 23504016, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 23504016, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L13" /protein_id="NP_388030.2" /db_xref="EnsemblGenomes-Gn:BSU01490" /db_xref="EnsemblGenomes-Tr:CAB11925" /db_xref="GOA:P70974" /db_xref="InterPro:IPR005822" /db_xref="InterPro:IPR005823" /db_xref="InterPro:IPR023563" /db_xref="InterPro:IPR036899" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11970" /db_xref="UniProtKB/Swiss-Prot:P70974" /translation="MRTTPMANASTIERKWLVVDAAGKTLGRLSSEVAAILRGKHKPT YTPHVDTGDHVIIINAEKIELTGKKLTDKIYYRHTQHPGGLKSRTALEMRTNYPEKML ELAIKGMLPKGSLGRQMFKKLNVYRGSEHPHEAQKPEVYELRG*" /label="rplM CDS" gene 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /label="rplM gene" CDS 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 19653700, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S9" /protein_id="NP_388031.1" /db_xref="EnsemblGenomes-Gn:BSU01500" /db_xref="EnsemblGenomes-Tr:CAB11926" /db_xref="GOA:P21470" /db_xref="InterPro:IPR000754" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020574" /db_xref="InterPro:IPR023035" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19007" /db_xref="UniProtKB/Swiss-Prot:P21470" /translation="MAQVQYYGTGRRKSSVARVRLVPGEGRIVVNNREISEHIPSAAL IEDIKQPLTLTETAGTYDVLVNVHGGGLSGQAGAIRHGIARALLEADPEYRTTLKRAG LLTRDARMKERKKYGLKGARRAPQFSKR*" /label="rpsI CDS" gene 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /label="rpsI gene" downshifts 154258 /Source="Nicolas_upshifts" /id="D53" /incds=0 /nref=262 /ntot=282 /MaxReadThrough="4.65387" /MaxDrop="8.11906" /score="30.5093496" /energy="-13.3" /TU="U98,U100,U102" /idTUdmin="U98" /TUdmin="-1227" /isTUend="FALSE" /label="downshifts" promotor_-35 154400..154407 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 154421..154440 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 154429..154710 /Source="Nicolas_S_feature" /locus_tag="new_154838_155119" /HighExp="H2O2, G180, G135, Paraq, Diami, dia15, Oxctl, Cold, Heat, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.479, 1" /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S59" upshifts 154429 /Source="Nicolas_upshifts" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature 154709..154728 /Source="Nicolas_upshift_promotors" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 154712 /Source="Nicolas_upshifts" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26582911; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388032.2" /db_xref="EnsemblGenomes-Gn:BSU01510" /db_xref="EnsemblGenomes-Tr:CAB11927" /db_xref="GOA:P70976" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11994" /db_xref="UniProtKB/Swiss-Prot:P70976" /translation="MNALVAHNSKAWDKKVETGNEWTVAVEQQVIEQAKKGNWDIRVT PMKDVPKDWFPPIKGLKVLCLASGGGQQGPVLAAAGADVTVLDNSEKQLNQDRMIAER DGLTIHTVKGSMDDLSVFNDESFDVIVHPVANVFVENVLPVWKEAYRVLKRNGILISG FVNPVVFLFDTELEQQGVLKVKHSIPYADPEDLPKHKVKKLIENNEALEFGHSLEDQI KGQIDAGFIVTGFYEDKGGFVLDQYIHTYSATRSVKV*" /label="ybaJ CDS" gene 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /label="ybaJ gene" downshifts 155505 /Source="Nicolas_upshifts" /id="D54" /incds=0 /nref=215 /ntot=251 /MaxReadThrough="2.69346" /MaxDrop="6.09641" /score="4.42269359" /energy="-10.3" /TU="NA" /idTUdmin="U100" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 155644..155650 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 155665..155676 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 155672 /Source="Nicolas_upshifts" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679227, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388033.1" /db_xref="EnsemblGenomes-Gn:BSU01520" /db_xref="EnsemblGenomes-Tr:CAB11928" /db_xref="GOA:P50862" /db_xref="InterPro:IPR019667" /db_xref="SubtiList:BG11503" /db_xref="UniProtKB/Swiss-Prot:P50862" /translation="MAEVLSFMDVKRQKDFELEKNLLKELSLRQIIQSVKDCLEPLFP FLHDERDIITEGCIDFAIEAYLLGGRFGIFGYYGESMQSISARSAREEEELRMEFFDY LYNWIHEQYATFDKNTVYEAARKFIKDWWTAGFVQREKQCKLRMR*" /label="ybaK CDS" gene 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /label="ybaK gene" promotor_-35 156143..156148 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 156164..156182 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 156165 /Source="Nicolas_upshifts" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /EC_number="3.5.1.28" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_388034.1" /db_xref="EnsemblGenomes-Gn:BSU01530" /db_xref="EnsemblGenomes-Tr:CAB11929" /db_xref="GOA:P50864" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR014234" /db_xref="SubtiList:BG11514" /db_xref="UniProtKB/Swiss-Prot:P50864" /translation="MRKKLKWLSFLLGFIILLFLFKYQFSNNDSWKPWSLPLSGKIIY LDPGHGGPDGGAVGGKLLEKDVTLEVAFRVRDYLQEQGALVIMTRESDTDLAPEGTKG YSRRKAEDLRQRVKLINHSEAELYISIHLNAIPSQKWSGAQSFYYGKYAENEKVAKYI QDELRRNLENTTRKAKRIHGIYLMQNVTKPGALIEVGFLSNPSEATLLGKPKYQDKVA SSIYKGILRYFTEKGDPPE*" /label="cwlD CDS" gene 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /label="cwlD gene" upshifts 156961 /Source="Nicolas_upshifts" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="upshifts" misc_feature 156964..156983 /Source="Nicolas_upshift_promotors" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11790741, 15126467, 26094643" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11790741, 15126467, 26094643; Product type r: regulator" /codon_start=1 /transl_table=11 /product="phosphorylation-dependent (Y327) transcriptionalregulator" /protein_id="NP_388035.1" /db_xref="EnsemblGenomes-Gn:BSU01540" /db_xref="EnsemblGenomes-Tr:CAB11930" /db_xref="GOA:P50863" /db_xref="InterPro:IPR000808" /db_xref="InterPro:IPR019591" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG11494" /db_xref="UniProtKB/Swiss-Prot:P50863" /translation="MIREDEVRKLVGEMREPFLQRPLGELDAVKEIKIKPEKRHISVK VALAKTGTAEQMQIQQEIVNVLKGAGAETVGLRFEELPEETVAKFRAPSAEKKTLLNM DNPPVFLAVASGKGGVGKSTVSVNLAISLARLGKKVGLIDADIYGFSVPDMMGITVRP TIEGEKLLPVERFGVKVMSMGFFVEENAPVVWRGPMLGKMLNNFFHEVEWGEVDYIVL DLPPGTGDVALDVHTMLPSCKEIIVSTPHPTAAFVAARAGSMAIKTDHEVVGVIENMA YYESAKTGEREYVFGKGGGDKLAEELNVPLLGRIPLKQPDWDKDQFAPSVYDENHPIG EIYQDIAKKIDAKMSVQV*" /label="salA CDS" gene 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /label="salA gene" S_feature complement(157641..158105) /Source="Nicolas_S_feature" /locus_tag="new_158050_158514_c" /HighExp="S8, S7, S6, S5, C30, S4, C90, nit, ferm, Gly" /AntisenseName="salA" /AntisenseCor="-0.104183954485248" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S60" downshifts 158056 /Source="Nicolas_upshifts" /id="D55" /incds=0 /nref=29 /ntot=155 /MaxReadThrough="5.44939" /MaxDrop="4.18382" /score="-4.46878413" /energy="-9.1" /TU="U107" /idTUdmin="U106" /TUdmin=1185 /isTUend="FALSE" /label="downshifts" S_feature 158101..158772 /Source="Nicolas_S_feature" /locus_tag="new_158510_159181" /HighExp="Lbtran, H2O2, Cold, Lbstat, dia5, M40t45, M0t90, M40t90, T0.30H, S1" /AntisenseName="gerD" /AntisenseCor="-0.24235509346425901" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S61" CDS complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17122337, 10618233, 10376819, 24530795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17122337, 10618233, 10376819, 24530795; Product type f: factor" /codon_start=1 /transl_table=11 /product="lipoprotein factor mediating clustering of germination proteins" /protein_id="NP_388036.1" /db_xref="EnsemblGenomes-Gn:BSU01550" /db_xref="EnsemblGenomes-Tr:CAB11931" /db_xref="GOA:P16450" /db_xref="SubtiList:BG10644" /db_xref="UniProtKB/Swiss-Prot:P16450" /translation="MSKAKTLLMSCFLLLSVTACAPKDQAADMDYDQTKKMVVDILKT DDGKKAIKELLNDDAMNEALVIDQDAIKGTIEKTLTSKKGEEFWKNIFEDTDFAEGFA KTLQTEHEKVIKKLMKDPDYQKMLMSVMQDPGMDKKYSQLAKSQEFRSYLEEVINETL SSPLYKKQFEDELKKAAKDTAKESE*" /label="gerD CDS" gene complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /label="gerD gene" promotor_-10 complement(158695..158706) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(158707) /Source="Nicolas_upshifts" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(158720..158726) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(158740..159369) /Source="Nicolas_S_feature" /locus_tag="new_159149_159778_c" /HighExp="S3, T5.0H, S4, S8, M9-stat, T4.0H, T3.30H, S7, T3.0H, S6" /AntisenseName="kbaA" /AntisenseCor="7.9344921760152495E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S62" CDS 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8576055, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576055, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inner membrane protein involved in activation ofthe KinB signaling pathway to sporulation" /protein_id="NP_388037.1" /db_xref="EnsemblGenomes-Gn:BSU01560" /db_xref="EnsemblGenomes-Tr:CAB11932" /db_xref="GOA:P16449" /db_xref="InterPro:IPR024164" /db_xref="SubtiList:BG10643" /db_xref="UniProtKB/Swiss-Prot:P16449" /translation="MKSRGLVRFFFSILAVGALITSIVGFALKWGEYRGLFLTFEAGQ IFSVLFWFIGVGMIFSVISQMGFFVFLTVHRFALEILRSSSLWNLLQLFFILFVAFDL MYVRFLFFGESGESLAGYAWLPVFLLIFGVITAYIKQKQSSKKTFVSSLFLMVVITAL EWFPALRVNDEDWLYLMLFPLMACNAFQLLMLPKFAAK*" /label="kbaA CDS" gene 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /label="kbaA gene" S_feature 159370..160264 /Source="Nicolas_S_feature" /locus_tag="new_159779_160673" /HighExp="Lbstat, Lbtran, M0t90, M40t90, H2O2, BC, Glucon, S7, M40t45, S1" /AntisenseName="ybaN" /AntisenseCor="-2.6735901031407501E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S63" CDS complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 15598884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 15598884; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="polysaccharide deacetylase involved in sporulation" /protein_id="NP_388038.1" /db_xref="EnsemblGenomes-Gn:BSU01570" /db_xref="EnsemblGenomes-Tr:CAB11933" /db_xref="GOA:P50865" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014132" /db_xref="SubtiList:BG11416" /db_xref="UniProtKB/Swiss-Prot:P50865" /translation="MNHFYVWHIKRVKQLIIILIAAFAAASFFYIQRAVPLPVFSTDT GPKAIYKGETDSKDISLTFDISWGDERAEPILNTLKANGIKNATFFLSASWAERHPDT VARIVKDGHQIGSMGYAYKNYANLESSEIKKDMNRAQTAFEKLGVKDIQLLRPPTGQF NKNVLKVAKQYNYTVVHYSVNSQDWTNPGVEKIIDNVTKQVSGGDIILLHASDSAKQT EEALPDIIHQLKEKGLKNVTVGDLIANSDAKSAEVK*" /label="pdaB CDS" gene complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /label="pdaB gene" promotor_-10 complement(160165..160183) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(160185) /Source="Nicolas_upshifts" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(160199..160204) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 160242..160249 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 160264..160283 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 160266..160483 /Source="Nicolas_S_feature" /locus_tag="new_160675_160892" /HighExp="Diami, LBGstat, UNK1, H2O2, MG 15, Oxctl, MG-0.1, BMM, T-1.10H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S64" upshifts 160266 /Source="Nicolas_upshifts" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-16S rRNA" gene 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /modified_by="User" /label="rrnI-16S gene" Polymorphism join(160830,160832) /Source="geneious" /ID="SNP_BsDelta6_161240_161239" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=45 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value="4.2e-57" /Variant_Raw_Frequency=41 /comment="rrnI-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-23S rRNA" gene 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /label="rrnI-23S gene" rRNA 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /product="ribosomal RNA-5S" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-5S rRNA" gene 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /label="rrnI-5S gene" Polymorphism join(165341,165342) /Source="geneious" /ID="SNP_BsDelta6_165748_165749" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="-TC" /Codon_Change /Coverage="172 -> 174" /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TC" /Variant_Nucleotides /Variant_P_Value="1.5e-307" /Variant_Raw_Frequency=152 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(165342,165344) /Source="geneious" /ID="SNP_BsDelta6_165751_165751" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="C -> T" /Codon_Change /Coverage=172 /locus_tag /Protein_Effect /Reference_Frequency="1.2%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=168 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Asn tRNA" gene 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /label="trnI-Asn gene" Polymorphism join(165417,165419) /Source="geneious" /ID="SNP_BsDelta6_165826_165825" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=163 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=160 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(GGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Thr tRNA" gene 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /label="trnI-Thr gene" tRNA 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Gly tRNA" gene 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /label="trnI-Gly gene" Polymorphism join(165630,165632) /Source="geneious" /ID="SNP_BsDelta6_166038_166037" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="T" /Codon_Change /Coverage=154 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=148 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg(AGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Arg tRNA" gene 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /label="trnI-Arg gene" tRNA 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Pro tRNA" gene 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /label="trnI-Pro gene" tRNA 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Ala tRNA" gene 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /label="trnI-Ala gene" Polymorphism join(165937,165938) /Source="geneious" /ID="SNP_BsDelta6_166344_166344" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-G" /Codon_Change /Coverage=132 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides /Variant_P_Value="4.9e-75" /Variant_Raw_Frequency=130 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-16S rRNA" gene 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /label="rrnH-16S gene" rRNA 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-23S rRNA" gene 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /label="rrnH-23S gene" rRNA 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-5S rRNA" gene 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /label="rrnH-5S gene" rRNA 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-16S rRNA" gene 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /label="rrnG-16S gene" rRNA 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-23S rRNA" gene 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /label="rrnG-23S gene" rRNA 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-5S rRNA" gene 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /label="rrnG-5S gene" S_feature 175915..176523 /Source="Nicolas_S_feature" /locus_tag="new_176316_176924" /HighExp="G180, G135, C30, Oxctl, Paraq, Cold, G150, H2O2, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S65" promotor_-35 176491..176495 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 176511..176530 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 176525..176681 /Source="Nicolas_S_feature" /locus_tag="new_176926_177082" /HighExp="LBGstat, G180, G135, dia15, C30, Oxctl, LPhT, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S66" upshifts 176525 /Source="Nicolas_upshifts" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="upshifts" CDS 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388039.1" /db_xref="EnsemblGenomes-Gn:BSU01580" /db_xref="EnsemblGenomes-Tr:CAB11934" /db_xref="GOA:P55189" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR018045" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11562" /db_xref="UniProtKB/Swiss-Prot:P55189" /translation="MNNSFTLKQQWFGNIRKDILAGILVALALIPEAIGFSIIAGVDP MVGLYASFCIAIIISIFGGRPGMISAATGSMAVVMVSLVADHGLQYLFAATILTGIIQ VILGISKIARLMKFIPRSVMIGFVNALAILIFSAQLPQFEGASWSMYAMLAGSLVIIY VLPRFTTAVPSPLVAIIVMTIIAVTFHVDVRTVGDMGNISSSLPHFLIPDVPFTFETL QIIFPYSIALAFVGLLESLLTAQIIDEMTDTDSDKNKESRGQGIANIVTGFFGGMAGC AMIGQSVINTKAGGRGRLSAFVAGAFLMFLIAVLSHVVVKIPMAALVAVMVMVSVGTF DWSSLKGLKKAPLTDSIVMVVTVVTVVVTDDLSKGVFVGVLLSAVFFVAKISKLKIVS HAEDQKLRTYQVKGQIFFASVTDLTNAFIYQEDIERVVIDLTEAHVWDDSGAAALDKI VAKFKEQGIEAELKGLNKASKSLMKQMA*" /label="ybaR CDS" gene 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /label="ybaR gene" downshifts 178107 /Source="Nicolas_upshifts" /id="D56" /incds=0 /nref=144 /ntot=228 /MaxReadThrough="2.81758" /MaxDrop="4.71162" /score="18.4600501" /energy="-12" /TU="NA" /idTUdmin="U111" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 178161..178166 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 178179..178198 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 178197 /Source="Nicolas_upshifts" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="upshifts" CDS 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium dependent transporter" /protein_id="NP_388040.2" /db_xref="EnsemblGenomes-Gn:BSU01590" /db_xref="EnsemblGenomes-Tr:CAB11935" /db_xref="GOA:P55190" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG11563" /db_xref="UniProtKB/Swiss-Prot:P55190" /translation="MPLLTPTSVVLGVLLSQFLNGYEWAVPWIFAFITFAGSLSANFQ SLRHALSHPLPMILALFVLHIFMPLFAWGSGHLIFKGDPLTITGLTLAVVIPTGITSL IWAAMYKGNVGLTLSIILVDTVLSPLIVPLSLSLLAGAQVHMDVWGMMKGLIVMVVIP SFLGMLFNQMSSPERTAFVSSALSPFSKLCLMAVIAINSSAIAPYFKSIDLRFAGIAV TVFFIALTGYAAAWLIGKMMKRRQEEIVSLIFTGGMRNISAGAVLAVTFFPSQVAVPV VIGMLFQQILAALFGYMLNRFELKPMLQKA*" /label="ybaS CDS" gene 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /label="ybaS gene" downshifts 179165 /Source="Nicolas_upshifts" /id="D57" /incds=0 /nref=33 /ntot=224 /MaxReadThrough="1.3063" /MaxDrop="3.58628" /score="13.3102824" /energy="-10.5" /TU="NA" /idTUdmin="U112" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 2974033, 17725565, 22210890, 28283524" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 2974033, 17725565, 22210890, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-chelator (enterobactin family) esterase" /protein_id="NP_388041.2" /db_xref="EnsemblGenomes-Gn:BSU01600" /db_xref="EnsemblGenomes-Tr:CAB11936" /db_xref="GOA:P55192" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11565" /db_xref="UniProtKB/Swiss-Prot:P55192" /translation="MKGSLSEHKAGNRRFTLYLPPSYSTDSGGFPAVYVQDGSSLFQN QIELLESAFQQQRLPELVLIGIEPENRLDEYTPWPAASLSDRFTDFGGMGYHYLSDIT NQFIPLIEENWNVTREPQSRGMIGASLGGLISMFAILKYPSMFGKIGSISGSYWYENA AETIHISSLKPGTARVFMSIGSEEGREKQSIQRHMLKKTKQVHQSLKEKGFTEDQLCL SIEKGAVHHHKYFCKQFINALEWLYGKNRSTL*" /label="eesA CDS" gene complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /label="eesA gene" downshifts complement(179218) /Source="Nicolas_upshifts" /id="D58" /incds=0 /nref=15 /ntot=115 /MaxReadThrough="0.3819" /MaxDrop="4.57603" /score="25.9728338" /energy="-10.5" /TU="NA" /idTUdmin="U114" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2651410, 15849754, 16850406, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-uptake protein" /protein_id="NP_388042.2" /db_xref="EnsemblGenomes-Gn:BSU01610" /db_xref="EnsemblGenomes-Tr:CAB11937" /db_xref="GOA:P40411" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10837" /db_xref="UniProtKB/Swiss-Prot:P40411" /translation="MAKKYALFIALILVVSYFSLTSGSFSVRPAELLSTLFQIDPNPQ YEILLFDLRLPRVVMAAIIGLGLGIAGAVIQAITRNGLADPGILGINAGAGAGIVAFM LLFQGQKEVTSIAAAMGMPLFGLIGGLIAAILIYIFAWHRGNLDSGRIILVGIAINSG FSALSLFLSLKMDPQDYQMAMVWKNGSIWSANWTYITAVLPWMLLFIPILIGKSRLLD TIRFDEDTVRSLGISSNKEKTILLVACVAIISACVSVAGSMAFVGLIAPHISRRLAGV EHRYILPLSGLIGMLLVISADFAGKLFFQPAEVPAGIILAILGVPYFLYLLFKQKKGE NA*" /label="feuC CDS" gene complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /label="feuC gene" CDS complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2651410, 15849754, 16850406, 17725565; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin permease" /protein_id="NP_388043.1" /db_xref="EnsemblGenomes-Gn:BSU01620" /db_xref="EnsemblGenomes-Tr:CAB11938" /db_xref="GOA:P40410" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10836" /db_xref="UniProtKB/Swiss-Prot:P40410" /translation="MYSKQWTRIILITSPFAIALSLLLSILYGAKHLSTDIVFTSLIH FDPGNTDHQIIWHSRIPRAAGALLIGAALAVSGALMQGITRNYLASPSIMGVSDGSAF IITLCMVLLPQSSSIEMMIYSFIGSALGAVLVFGLAAMMPNGFTPVQLAIIGTVTSML LSSLSAAMSIYFQISQDLSFWYSARLHQMSPDFLKLAAPFFLIGIIMAISLSKKVTAV SLGDDISKSLGQKKKTIKIMAMLSVIILTGSAVALAGKIAFVGLVVPHITRFLVGSDY SRLIPCSCILGGIFLTLCDLASRFINYPFETPIEVVTSIIGVPFFLYLIKRKGGEQNG *" /label="feuB CDS" gene complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /label="feuB gene" CDS complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8388528, 16889643, 17725565, 21802011, 22303020, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8388528, 16889643, 17725565, 21802011, 22303020, 25355936; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin-binding lipoprotein" /protein_id="NP_388044.1" /db_xref="EnsemblGenomes-Gn:BSU01630" /db_xref="EnsemblGenomes-Tr:CAB11939" /db_xref="GOA:P40409" /db_xref="InterPro:IPR002491" /db_xref="PDB:2PHZ" /db_xref="PDB:2WHY" /db_xref="PDB:2WI8" /db_xref="PDB:2XUZ" /db_xref="PDB:2XV1" /db_xref="SubtiList:BG10835" /db_xref="UniProtKB/Swiss-Prot:P40409" /translation="MKKISLTLLILLLALTAAACGSKNESTASKASGTASEKKKIEYL DKTYEVTVPTDKIAITGSVESMEDAKLLDVHPQGAISFSGKFPDMFKDITDKAEPTGE KMEPNIEKILEMKPDVILASTKFPEKTLQKISTAGTTIPVSHISSNWKENMMLLAQLT GKEKKAKKIIADYEQDLKEIKTKINDKAKDSKALVIRIRQGNIYIYPEQVYFNSTLYG DLGLKAPNEVKAAKAQELSSLEKLSEMNPDHIFVQFSDDENADKPDALKDLEKNPIWK SLKAVKEDHVYVNSVDPLAQGGTAWSKVRFLKAAAEKLTQN*" /label="feuA CDS" gene complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /label="feuA gene" promotor_-35 182282..182288 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 182303..182321 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 182312 /Source="Nicolas_upshifts" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(182953..182972) /Source="Nicolas_upshift_promotors" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(182960) /Source="Nicolas_upshifts" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16889643, 17725565, 17962296, 22210890" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16889643, 17725565, 17962296, 22210890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AraC/XylS family) of synthesis and uptake of the siderophore bacillibactin" /protein_id="NP_388045.1" /db_xref="EnsemblGenomes-Gn:BSU01640" /db_xref="EnsemblGenomes-Tr:CAB11940" /db_xref="GOA:P40408" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG10834" /db_xref="UniProtKB/Swiss-Prot:P40408" /translation="MQNAVIYQPVQIEYLKKTSDLFSEQQLADSFVLIFHLKGNGYIS IGTNTNPLQKKTLYVCPPNETFGFTPAADGHIDACIIRLLSYIKETGQDIFTPCTESE LAKLKLMNVSHIENLAVRLQELAALWNESSQLSQLKCVIEVQSLIYDLFTASLSDQTD THSAIEKTKHYIETHADTKITLAQLSQMAGISAKHYSESFKKWTGQSVTEFITKTRIT KAKRLMAKSNCKLKEIAHQTGYQDEFYFSRIFKKYTGCSPTSYMKKRRKKIAAYGRGT MGHLIPLHHIPFAAALHPKWTSYYYQHYSTDIPVQLSAYRFNEKWEENLYTLSQAEPD VIVSMDSISPEEQDRLNRIAEVMYLPSEESWRTHFLQTASFLKEESEAEKWLADYDQQ TTAAKKTLQHVQGLRFLFLRLHKQNFYLAHNRSVREVFFGDLGFSSATTADTPSEQAI SLENIANYQADCMMLFLFKEPETIAYYQQLQQTEAWQNLSAVRDNRVYLLSLDPWNEY SACGHERIVQQTVSLLSGDCP*" /label="btr CDS" gene complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /label="btr gene" promotor_-10 complement(184643..184662) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(184655) /Source="Nicolas_upshifts" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(184677..184684) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(184764) /Source="Nicolas_upshifts" /id="D59" /incds=0 /nref=19 /ntot=58 /MaxReadThrough="1.28464" /MaxDrop="7.13916" /score="9.64466628" /energy="-10.1" /TU="NA" /idTUdmin="U116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388046.1" /db_xref="EnsemblGenomes-Gn:BSU01650" /db_xref="EnsemblGenomes-Tr:CAB11941" /db_xref="InterPro:IPR008302" /db_xref="SubtiList:BG10833" /db_xref="UniProtKB/Swiss-Prot:P40407" /translation="MRKTIFAFLTGLMMFGTITAASASPDSKNQTAKKPKVQTGIDTL LPDYKKQLKGKRIGLITNPAGVNTSLKSSVDILYENPDIKLTALFGPEHGVRGDAQAG DEVGSYIDEKTGVPVYSLYGKTKKPTPEMLKNVDILMFDIQDVGTRFYTYIYTMAYAM EAAKENGIPFMVLDRPNPQGGNHIEGPILEPEYASFVGLYPIPLKHGMTIGELASLFN KEFSIDADLTVVKMKHWKRKMDFDDTRLPFVLPSPNMPTVESTFVYPATGLIEGTNIS EGRGTTKPFELIGAPFIKSTELEETLNSLHLPGVTFRAASFTPTFSKHQGTLCHGVQL YVTDRDKFEAVKTGLSVIKTIHDLYPEDFEFLSTGSFDKLAGNGWIRTKIENGTSVEN IINSYEKTLQQFSKTRKKYLIY*" /label="ybbC CDS" gene complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /label="ybbC gene" downshifts complement(184814) /Source="Nicolas_upshifts" /id="D60" /incds=0 /nref=11 /ntot=122 /MaxReadThrough="7.66074" /MaxDrop="4.10379" /score="9.64466628" /energy="-10.1" /TU="U116" /idTUdmin="U116" /TUdmin="-50" /isTUend="FALSE" /label="downshifts" CDS complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /EC_number="3.2.1.52" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8063094, 20400549, 20826810, 23177201, 26963691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8063094, 20400549, 20826810, 23177201, 26963691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosaminidase lipoprotein" /protein_id="NP_388047.1" /db_xref="EnsemblGenomes-Gn:BSU01660" /db_xref="EnsemblGenomes-Tr:CAB11942" /db_xref="GOA:P40406" /db_xref="InterPro:IPR001764" /db_xref="InterPro:IPR002772" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR019800" /db_xref="InterPro:IPR036881" /db_xref="InterPro:IPR036962" /db_xref="PDB:3BMX" /db_xref="PDB:3LK6" /db_xref="PDB:3NVD" /db_xref="PDB:4GYJ" /db_xref="PDB:4GYK" /db_xref="SubtiList:BG10832" /db_xref="UniProtKB/Swiss-Prot:P40406" /translation="MRPVFPLILSAVLFLSCFFGARQTEASASKRAIDANQIVNRMSL DEKLGQMLMPDFRNWQKEGESSPQALTKMNDEVASLVKKYQFGGIILFAENVKTTKQT VQLTDDYQKASPKIPLMLSIDQEGGIVTRLGEGTNFPGNMALGAARSRINAYQTGSII GKELSALGINTDFSPVVDINNNPDNPVIGVRSFSSNRELTSRLGLYTMKGLQRQDIAS ALKHFPGHGDTDVDSHYGLPLVSHGQERLREVELYPFQKAIDAGADMVMTAHVQFPAF DDTTYKSKLDGSDILVPATLSKKVMTGLLRQEMGFNGVIVTDALNMKAIADHFGQEEA VVMAVKAGVDIALMPASVTSLKEEQKFARVIQALKEAVKNGDIPEQQINNSVERIISL KIKRGMYPARNSDSTKEKIAKAKKIVGSKQHLKAEKKLAEKAVTVLKNEQHTLPFKPK KGSRILIVAPYEEQTASIEQTIHDLIKRKKIKPVSLSKMNFASQVFKTEHEKQVKEAD YIITGSYVVKNDPVVNDGVIDDTISDSSKWATVFPRAVMKAALQHNKPFVLMSLRNPY DAANFEEAKALIAVYGFKGYANGRYLQPNIPAGVMAIFGQAKPKGTLPVDIPSVTKPG NTLYPLGYGLNIKTGRPL*" /label="nagZ CDS" gene complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /label="nagZ gene" CDS complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16452451, 20400549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16452451, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidase hydrolyzing N-acetylmuramyl-L-Ala bond of MurNAc peptides" /protein_id="NP_388048.2" /db_xref="EnsemblGenomes-Gn:BSU01670" /db_xref="EnsemblGenomes-Tr:CAB11943" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR022849" /db_xref="SubtiList:BG11566" /db_xref="UniProtKB/Swiss-Prot:O05213" /translation="MKTKTLFIFSAILTLSIFAPNETFAQTAGNLIEPKIINAETAQF STKKLRKVDQMIERDIAAGFPGAVLVVVKDGRIIKKAAYGYSKKYEGSELLRRPAKMK TRTMFDLASNTKMYATNFALQRLVSQGKLDVYEKVSAYLPGFKDQPGDLIKGKDKIRV IDVLQHQSGLPSSFYFYTPEKAGKYYSQERDKTIEYLTKIPLDYQTGTKHVYSDIGYM LLGCIVEKLTGKPLDVYTEQELYKPLRLKHTLYNPLQKGFKPKQFAATERMGNTRDGV IQFPNIRTNTLQGEVHDEKAFYSMDGVSGHAGLFSNADDMAILLQVMLNKGSYRNISL FDQKTADLFTAPSATDPTFALGWRRNGSKSMEWMFGPHASENAYGHTGWTGTVTIIDP AYNLGIALLTNKKHTPVIDPEENPNVFEGDQFPTGSYGSVITAIYEAME*" /label="amiE CDS" gene complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /label="amiE gene" CDS complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /EC_number="2.7.1.192" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060041, 15849754, 16850406, 10627040, 20400549, 22960854; Product type t : transporter" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid PTS permease-MurP subunit" /protein_id="NP_388049.3" /db_xref="EnsemblGenomes-Gn:BSU01680" /db_xref="EnsemblGenomes-Tr:CAB11944" /db_xref="GOA:Q797S1" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11567" /db_xref="UniProtKB/Swiss-Prot:Q797S1" /translation="MSKENNYHHLAQKILELCGGKSNISSYTHCMTRLRITPYDESKA DAQALRKLDGVLGVVEAETLQIILGTGVVNHVTAAFSKLVSAEEGADVKEAAAKKKAD INRKNATPFKLFLRKIASIFIPLIPALVASGLITGITKAIIQAGWLSADSQIAIILTV IGSGLFTYLGILVGINASKEFGGTPALGALAGILIINPEIAKISLFGEELLPGRGGLI GVLFAAIFIAYTEQFIRRFIPQSLDIIVTPTVSLLITGIVTYVVFMPLGGFISDAITS GLLSILDIGGIAAGFILGATFLPLVVTGLHQGLTPVHMELINSIGNDPLLPILAMGGA GQVGAAFAVFVKTKKTTLRKAIAGGLPSGLLGIGEPLIFGVTLPLGRPFLTACLGAGI GGAFQAYFQVATIAIGVSGLPLSFLVLPSQIILYIVGLFISYAAGFLLTYAFGYKDEM ASQFD*" /label="murP CDS" gene complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /label="murP gene" CDS complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20400549; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator MurR-N-acetylmuramic acid" /protein_id="NP_388050.1" /db_xref="EnsemblGenomes-Gn:BSU01690" /db_xref="EnsemblGenomes-Tr:CAB11945" /db_xref="GOA:Q45581" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="PDB:2O3F" /db_xref="SubtiList:BG11569" /db_xref="UniProtKB/Swiss-Prot:Q45581" /translation="MATGGLAIIQSMKHKLPPSERKLADYILAHPHKAIESTVNEISA LANSSDAAVIRLCKSLGLKGFQDLKMRVAGDLAKPTFQGYRDIVPHEPLPSISEKTAG NAIQAIQDTSDLMDYKELERAVSLLLKAHTVHFIGLGASGIVAKDAQQKWLRIHKQAT AFTDTHLVASLIANADKDDIVFAISFSGETQEIVELFAMAKEKGITTISLTQFSQTSV SALADVPLYTAHSNEALIRSAATSSRLAQLFIIDVLFLGMAAEQYETTTGYIDKTRAA IQSMRIK*" /label="murR CDS" gene complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /label="murR gene" CDS complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /EC_number="4.2.1.126" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15983044, 20400549, 16452451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lactyl ether N-acetylmuramic-6-phosphate acid etherase" /protein_id="NP_388051.1" /db_xref="EnsemblGenomes-Gn:BSU01700" /db_xref="EnsemblGenomes-Tr:CAB11946" /db_xref="GOA:Q45582" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005486" /db_xref="InterPro:IPR005488" /db_xref="SubtiList:BG11570" /db_xref="UniProtKB/Swiss-Prot:Q45582" /translation="MSEPLNLHRLTTESRNSQTVEIHKANTLGILKMINNEDMKVAAA VQEVLPDIKTAVDCAYESFQNGGRLIYTGAGTSGRLGVMDAVECPPTYSVSPDQVIGI MAGGPEAFLQAAEGIEDSEEAGAEDLRNIQLTSNDTVIAIAASGRTPYAAGALRYARK VGAHTIALTCNENSAISKDADHSIEVVVGPEAITGSTRMKAATAHKMILNMISTAVMV KIGKVYENLMVDVNVSNKKLKERAISIIQSLTNASYDTARYTLEQADHHVKTAIVMLK TSTDQKQAQTLLDEANGFIDKAIEHYHP*" /label="murQ CDS" gene complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /label="murQ gene" promotor_-10 complement(192595..192613) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(192608) /Source="Nicolas_upshifts" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(192629..192636) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_388052.2" /db_xref="EnsemblGenomes-Gn:BSU01710" /db_xref="EnsemblGenomes-Tr:CAB11947" /db_xref="GOA:Q45583" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11571" /db_xref="UniProtKB/Swiss-Prot:Q45583" /translation="MTQDISLSFYKPEHLPELQSFTLTNDDKRFTSLPKEVLSQALGI QDRYPVVILKDDLPVGFFILHASKETLASYSNNPFALLLSSLSLTAVHHGKGYAKKAM LLLPAFVSGYFPWCDEIILAVNHLNIRAKHLYMKSGFLDKGRRRIGPLGEQLILHHFL *" /label="ybbJ CDS" gene complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /label="ybbJ gene" CDS complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388053.2" /db_xref="EnsemblGenomes-Gn:BSU01720" /db_xref="EnsemblGenomes-Tr:CAB11948" /db_xref="InterPro:IPR007553" /db_xref="SubtiList:BG11572" /db_xref="UniProtKB/Swiss-Prot:Q45584" /translation="MILVSSCLGGIECRYNGSHAASEKIRKLVDEKKAVMACPELLGG FSTPREPAEIIGGTGEDVLNGTAKIVTASGEDVTELYMEGAAKTLAYAKEINASAVIL KENSPSCGSGFIYNGTFSGKKITGSGVTAALLKQAGYRVISENELNDIL*" /label="ybbK CDS" gene complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /label="ybbK gene" promotor_-10 complement(193650..193669) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(193671) /Source="Nicolas_upshifts" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(193684..193685) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 193744..193751 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" promotor_-10 193766..193785 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" upshifts 193777 /Source="Nicolas_upshifts" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" tRNA 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu2 tRNA" gene 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /label="trnSL-Glu2 gene" tRNA 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val1 tRNA" gene 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /label="trnSL-Val1 gene" tRNA 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Thr1 tRNA" gene 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /label="trnSL-Thr1 gene" tRNA 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Tyr1 tRNA" gene 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /label="trnSL-Tyr1 gene" tRNA 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gln2 tRNA" gene 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /label="trnSL-Gln2 gene" downshifts 194223 /Source="Nicolas_upshifts" /id="D61" /incds=0 /nref=10 /ntot=91 /MaxReadThrough="4.25215" /MaxDrop="3.84626" /score="25.5087424" /energy="-11.4" /TU="U118" /idTUdmin="U118" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" S_feature 194268..194385 /Source="Nicolas_S_feature" /locus_tag="new_194669_194786" /HighExp="Paraq, BMM, H2O2, Heat, G180, G135, Oxctl, G150, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S67" promotor_-35 194386..194395 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" upshifts 194387 /Source="Nicolas_upshifts" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" promotor_-10 194407..194422 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" CDS 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11866510, 15130127, 16629676, 21542858, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11866510, 15130127, 16629676, 21542858, 28319136, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor W" /protein_id="NP_388054.1" /db_xref="EnsemblGenomes-Gn:BSU01730" /db_xref="EnsemblGenomes-Tr:CAB11949" /db_xref="GOA:Q45585" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014294" /db_xref="InterPro:IPR036388" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11573" /db_xref="UniProtKB/Swiss-Prot:Q45585" /translation="MEMMIKKRIKQVKKGDQDAFADIVDIYKDKIYQLCYRMLGNVHE AEDIAQEAFIRAYVNIDSFDINRKFSTWLYRIATNLTIDRIRKKKPDYYLDAEVAGTE GLTMYSQIVADGVLPEDAVVSLELSNTIQQKILKLPDKYRTVIVLKYIDELSLIEIGE ILNIPVGTVKTRIHRGREALRKQLRDL*" /label="sigW CDS" gene 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /label="sigW gene" CDS 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15130127, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 28319136, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(W) factor" /protein_id="NP_388055.1" /db_xref="EnsemblGenomes-Gn:BSU01740" /db_xref="EnsemblGenomes-Tr:CAB11950" /db_xref="GOA:Q45588" /db_xref="InterPro:IPR027383" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11574" /db_xref="UniProtKB/Swiss-Prot:Q45588" /translation="MSCPEQIVQLMHMHLDGDILPKDEHVLNEHLETCEKCRKHFYEM EKSIALVRSTSHVEAPADFTANVMAKLPKEKKRASVKRWFRTHPVIAAAAVFIILMGG GFFNSWHNDHNFSVSKQPNLVVHNHTVTVPEGETVKGDVTVKNGKLIIKGKIDGDVTV VNGEKYMASAGQVTGQIEEINQLFDWTWYKMKSAGKSVLDAFNPNGEE*" /label="rsiW CDS" gene 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /label="rsiW gene" downshifts complement(195443) /Source="Nicolas_upshifts" /id="D62" /incds=1 /nref=2 /ntot=181 /MaxReadThrough="1.52124" /MaxDrop="3.24828" /score="0.305471631" /energy="-6.9" /TU="NA" /idTUdmin="U120" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(195601..195701) /Source="Nicolas_upshift_promotors" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts 195631 /Source="Nicolas_upshifts" /id="D63" /incds=0 /nref=251 /ntot=269 /MaxReadThrough="4.26924" /MaxDrop="8.34597" /score="7.39786279" /energy="-10.8" /TU="U119" /idTUdmin="U119" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" upshifts complement(195641) /Source="Nicolas_upshifts" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 195700..195707 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-35" promotor_-10 195722..195741 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-10" S_feature 195731..195811 /Source="Nicolas_S_feature" /locus_tag="new_196132_196212" /HighExp="dia5, Diami, H2O2, dia15, G135, Cold, G180, Paraq, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA" /TUlongPSig="1, 1" /label="S68" upshifts 195731 /Source="Nicolas_upshifts" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="upshifts" CDS 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /EC_number="2.7.7.85" /function="16.13: Shape" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase" /protein_id="NP_388056.2" /db_xref="EnsemblGenomes-Gn:BSU01750" /db_xref="EnsemblGenomes-Tr:CAB11951" /db_xref="GOA:Q45589" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR034701" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG11577" /db_xref="UniProtKB/Swiss-Prot:Q45589" /translation="MAFEDIPFLQYLGNAVDILLVWYVIYKLIMVIRGTKAVQLLKGI VVIVLVRMASQYLGLSTLQWLMDQAITWGFLAIIIIFQPELRRALEQLGRGRFFSRSG TPVEEAQQKTIEAITKAINYMAKRRIGALLTIERDTGMGDYIETGIPLNAKVSSELLI NIFIPNTPLHDGAVIMKNNEIAAAACYLPLSESPFISKELGTRHRAAVGISEVTDSLT IIVSEETGGVSVAKNGDLHRELTEEALKEMLEAEFKKNTRDTSSNRWYWRGKKNG*" /label="cdaA CDS" gene 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /label="cdaA gene" CDS 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /experiment="publication(s) with functional evidences, PMID:16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of diadenylate cyclase activity" /protein_id="NP_388057.2" /db_xref="EnsemblGenomes-Gn:BSU01760" /db_xref="EnsemblGenomes-Tr:CAB11952" /db_xref="GOA:O34659" /db_xref="InterPro:IPR012505" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12703" /db_xref="UniProtKB/Swiss-Prot:O34659" /translation="MDKFLNNRWAVKIIALLFALLLYVAVNSNQAPTPKKPGESFFPT STTDEATLTDIPVKAYYDDENYVVTGVPQTVNVTIKGSTSAVKKARQTKNFEIYADME HLKTGTHKVELKAKNVSDGLTISINPSVTTVTIQERTTKSFPVEVEYYNKSKMKKGYS PEQPIVSPKNVQITGSKNVIDNISLVKASVNLENADETIEKEAKVTVYDKDGNALPVD VEPSVIKITVPVTSPSKKVPFKIERTGSLPDGVSIANIESSPSEVTVYGSQDVLDSLE FIDGVSLDLSKINKDSDIEADIPLPDGVKKISPSKVTLHIEVDSEADQKFENVPIKTV GLSSSQNIEFLDPESQAIDVTAKGSPTNINKLKKSDIELYVNVSDLEDGEHSVKLEVN GPQNVTWSLGRKNAKIKLTSKKSNTSTNDNSSNTSGNQDTDKQTNDQKNNQQEDTKNT DKNNNDQNQDGNKDQNQDQDEDESTANSQSSSE*" /label="cdaR CDS" gene 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /label="cdaR gene" CDS 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /EC_number="5.4.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10671448, 10913078, 12089032, 21154411, 26240071, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671448, 10913078, 12089032, 21154411, 26240071, 27074767; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoglucosamine mutase" /protein_id="NP_388058.1" /db_xref="EnsemblGenomes-Gn:BSU01770" /db_xref="EnsemblGenomes-Tr:CAB11953" /db_xref="GOA:O34824" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR006352" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG12704" /db_xref="UniProtKB/Swiss-Prot:O34824" /translation="MGKYFGTDGVRGVANSELTPELAFKVGRFGGYVLTKDKQRPKVL IGRDTRISGHMLEGALVAGLLSIGAEVMRLGVISTPGVSYLTKAMDAEAGVMISASHN PVQDNGIKFFGGDGFKLSDEQEAEIERLMDEPEDKLPRPVGADLGLVNDYFEGGQKYL QFLKQTADEDFTGIHVALDCANGATSSLATHLFADLDADVSTMGTSPNGLNINDGVGS THPEALSAFVKEKNADLGLAFDGDGDRLIAVDEKGNIVDGDQIMYICSKHLKSEGRLK DDTVVSTVMSNLGFYKALEKEGIKSVQTAVGDRYVVEAMKKDGYNVGGEQSGHLIFLD YNTTGDGLLSAIMLMNTLKATGKPLSELAAEMQKFPQLLVNVRVTDKYKVEENEKVKA VISEVEKEMNGDGRILVRPSGTEPLVRVMAEAKTKELCDEYVNRIVEVVRSEMGLE*" /label="glmM CDS" gene 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /label="glmM gene" downshifts 199437 /Source="Nicolas_upshifts" /id="D64" /incds=0 /nref=126 /ntot=216 /MaxReadThrough="5.32721" /MaxDrop="5.02497" /score="13.5044076" /energy="-17.5" /TU="U121" /idTUdmin="U121" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 199461..199469 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 199477 /Source="Nicolas_upshifts" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 199483..199502 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 199529..199534 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 199550..199569 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 199556 /Source="Nicolas_upshifts" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_feature 199600..199616 /Source="Nicolas_upshift_promotors" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 199613 /Source="Nicolas_upshifts" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /product="riboswitch and ribozyme (GlmS-glucosamine-6-P)" /experiment="publication(s) with functional evidences, PMID:16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261; Product type n: RNA" /label="glmSA RNA" gene 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /label="glmSA gene" S_feature 199787..199875 /Source="Nicolas_S_feature" /locus_tag="new_200188_200276" /HighExp="M40t90, M0t90, M9-stat, Lbstat, T2.30H, T2.0H, T3.0H, T1.30H, T1.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.498, 0.999, 0.754" /TUlongSig="SigA, SigWXY, SigA" /TUlongPSig="1, 1, 1" /label="S69" CDS 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /EC_number="2.6.1.16" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15029187, 17114942, 17283212, 17322533, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine-D-fructose-6-phosphate amidotransferase" /protein_id="NP_388059.1" /db_xref="EnsemblGenomes-Gn:BSU01780" /db_xref="EnsemblGenomes-Tr:CAB11954" /db_xref="GOA:P0CI73" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005855" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR035466" /db_xref="InterPro:IPR035490" /db_xref="SubtiList:BG10948" /db_xref="UniProtKB/Swiss-Prot:P0CI73" /translation="MCGIVGYIGQLDAKEILLKGLEKLEYRGYDSAGIAVANEQGIHV FKEKGRIADLREVVDANVEAKAGIGHTRWATHGEPSYLNAHPHQSALGRFTLVHNGVI ENYVQLKQEYLQDVELKSDTDTEVVVQVIEQFVNGGLETEEAFRKTLTLLKGSYAIAL FDNDNRETIFVAKNKSPLLVGLGDTFNVVASDAMAMLQVTNEYVELMDKEMVIVTDDQ VVIKNLDGDVITRASYIAELDASDIEKGTYPHYMLKETDEQPVVMRKIIQTYQDENGK LSVPGDIAAAVAEADRIYIIGCGTSYHAGLVGKQYIEMWANVPVEVHVASEFSYNMPL LSKKPLFIFLSQSGETADSRAVLVQVKALGHKALTITNVPGSTLSREADYTLLLHAGP EIAVASTKAYTAQIAVLAVLASVAADKNGINIGFDLVKELGIAANAMEALCDQKDEME MIAREYLTVSRNAFFIGRGLDYFVCVEGALKLKEISYIQAEGFAGGELKHGTIALIEQ GTPVFALATQEHVNLSIRGNVKEVAARGANTCIISLKGLDDADDRFVLPEVNPALAPL VSVVPLQLIAYYAALHRGCDVDKPRNLAKSVTVE*" /label="glmS CDS" gene 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /label="glmS gene" S_feature complement(201401..>201681) /Source="Nicolas_S_feature" /locus_tag="new_201802_202546_c" /HighExp="S8, S7, S6, S5, S4, BC, S3, Sw, C30, LoTm" /AntisenseName="glmS" /AntisenseCor="4.5056549205256403E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S70" downshifts 201664 /Source="Nicolas_upshifts" /id="D65" /incds=0 /nref=260 /ntot=277 /MaxReadThrough="3.18134" /MaxDrop="7.61794" /score="13.5044076" /energy="-17.5" /TU="NA" /idTUdmin="U122" /TUdmin=2 /isTUend="TRUE" /label="downshifts" SCAR join(201681,201727) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta4" N_region 201682..201726 /note="insertion of 45 bases of unknown origin" /modified_by="User" /label="Delta4" S_feature <201727..201845 /Source="Nicolas_S_feature" /locus_tag="new_220105_220278" /HighExp="LoTm, T5.0H, T4.0H, T3.30H, Pyr, T-2.40H, T3.0H, T-5.40H, S2, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.984" /TUlongSig="NA" /TUlongPSig="NA" /label="S79" CDS 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase/transferase" /protein_id="NP_388081.2" /db_xref="EnsemblGenomes-Gn:BSU01990" /db_xref="EnsemblGenomes-Tr:CAB11993" /db_xref="GOA:O31431" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12722" /db_xref="UniProtKB/Swiss-Prot:O31431" /translation="MKTLWKVLKIVFVSLAALVLLVSVSVFIYHHFQLNKEAALLKGK GTVVDVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAG YGYSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKA IIAMDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFIPSAVYNPEVIRQSFLTDE EKEIYKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKY AIQNRKDYEAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR*" /label="ybdG CDS" gene 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /label="ybdG gene" CDS 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component system response regulator [YbdK]" /protein_id="NP_388082.1" /db_xref="EnsemblGenomes-Gn:BSU02000" /db_xref="EnsemblGenomes-Tr:CAB11994" /db_xref="GOA:O31432" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12723" /db_xref="UniProtKB/Swiss-Prot:O31432" /translation="MKGYRILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQ KVDLVIMDVMLPGEDGYQMSAKIKKLGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKP FDPRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYL YENRDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLN TVVKK*" /label="ybdJ CDS" gene 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /label="ybdJ gene" promotor_-35 203390..203396 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 203410..203429 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 203428 /Source="Nicolas_upshifts" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component system sensor histidine kinase [YbdJ]" /protein_id="NP_388083.1" /db_xref="EnsemblGenomes-Gn:BSU02010" /db_xref="EnsemblGenomes-Tr:CAB11995" /db_xref="GOA:O31433" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12724" /db_xref="UniProtKB/Swiss-Prot:O31433" /translation="MLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMPFHRSFAY PAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVKRADEIG ELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLQLFYLEDQCHG QAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDYLYSM SGIELHYKPADQDVIWMSNTLWMERLFDNIFQNTLRHSKAKKMEVTIEHGDVFIRDDG IGFDRNESSEGLGLKIIEDTCRLLAITYELHTNDNGTGFLFSKE*" /label="ybdK CDS" gene 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /label="ybdK gene" promotor_-35 204491..204493 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 204509..204528 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 204512 /Source="Nicolas_upshifts" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097672.1" /db_xref="EnsemblGenomes-Gn:BSU02019" /db_xref="EnsemblGenomes-Tr:CAX52542" /db_xref="UniProtKB/Swiss-Prot:C0H3T1" /translation="MNIICLKKSSKRLSTSQAVLVTDIADTGITAAAGADIIAATAAV RAKEDTTTVMAAVIVTNAGATAAVNPKKVLVPLLGQGFFYVTD*" /label="ybzI CDS" gene 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /label="ybzI gene" downshifts 204742 /Source="Nicolas_upshifts" /id="D73" /incds=0 /nref=120 /ntot=235 /MaxReadThrough="2.82444" /MaxDrop="4.652" /score="22.3698707" /energy="-12.1" /TU="U135" /idTUdmin="U136" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /EC_number="2.7.11.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21304896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein kinase" /protein_id="NP_388085.1" /db_xref="EnsemblGenomes-Gn:BSU02030" /db_xref="EnsemblGenomes-Tr:CAB11997" /db_xref="GOA:O31435" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG12726" /db_xref="UniProtKB/Swiss-Prot:O31435" /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTD ILAQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLKNIHHPQIPGFIDEFIIDGQAYYVM QFIEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDG RLCLIDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEEL TLTKEVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT*" /label="ybdM CDS" gene complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /label="ybdM gene" CDS complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16794953; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388086.1" /db_xref="EnsemblGenomes-Gn:BSU02040" /db_xref="EnsemblGenomes-Tr:CAB11998" /db_xref="SubtiList:BG12727" /db_xref="UniProtKB/Swiss-Prot:O31436" /translation="MVKKWLIQFAVMLSVLSTFTYSASAVGVTAITGNNSFDTAMPIG YWKYKNIDTTILEAGQDEAYFTFTANKGEKVYMRSTYQSAYTGMKIEIYDKNRIPVSQ GTEVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQ FSGVAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHL IMTSENNEWSRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKID YEYDVTKQF*" /label="ybdN CDS" gene complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /label="ybdN gene" downshifts complement(205664) /Source="Nicolas_upshifts" /id="D74" /incds=0 /nref=95 /ntot=184 /MaxReadThrough="1.56932" /MaxDrop="4.95806" /score="36.4950689" /energy="-11.9" /TU="NA" /idTUdmin="U137" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(205713..205732) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(205746..205755) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(205748) /Source="Nicolas_upshifts" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(206512..206531) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(206537) /Source="Nicolas_upshifts" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(206546..206553) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 206567..206574 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-35" promotor_-10 206588..206606 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-10" upshifts 206590 /Source="Nicolas_upshifts" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="upshifts" CDS 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388087.1" /db_xref="EnsemblGenomes-Gn:BSU02050" /db_xref="EnsemblGenomes-Tr:CAB11999" /db_xref="InterPro:IPR032617" /db_xref="SubtiList:BG12728" /db_xref="UniProtKB/Swiss-Prot:O31437" /translation="MRLNRQFIRTQLIAQNILSKNAPAKRENATENPAAVLEKAYSRL KSQSSTGGINQFNYSKTSVSGNSGTFSKVYQSANDRTVTDTGEETVIQSQNPYESESD IRIKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEW LFKGKAQNYNLQDAVFRNVTFHGEVEAENEKVYQRGQVNQQLQVLLNRNHIHIPEGTE LTFTITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSAQFSEEA YKKYQAAREMYEVTGYHLKDLEVIDGRYVTPEGRDLMDVYKEELEKDPVQKQTASYAI SYYRSELSKIAEAGYNAIPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLEALKRQTGV NY*" /label="ybdO CDS" gene 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /label="ybdO gene" downshifts 207801 /Source="Nicolas_upshifts" /id="D75" /incds=0 /nref=107 /ntot=207 /MaxReadThrough="2.98334" /MaxDrop="4.9582" /score="-3.87053033" /energy="-8.3" /TU="U139" /idTUdmin="U139" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" promotor_-35 207969..207975 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 207989..208008 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 208003..208132 /Source="Nicolas_S_feature" /locus_tag="new_226436_226565" /HighExp="Glu, LoTm, M9-stat, G135, GM-0.2, T-0.40H, Fru, UNK1, MG 120, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD" /TUlongPSig=1 /label="S80" upshifts 208003 /Source="Nicolas_upshifts" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="upshifts" CDS 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388088.1" /db_xref="EnsemblGenomes-Gn:BSU02060" /db_xref="EnsemblGenomes-Tr:CAB12000" /db_xref="GOA:P54425" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11505" /db_xref="UniProtKB/Swiss-Prot:P54425" /translation="MANKELKRGLGARHIQMIALGGTIGVGLFMGSASTISWTGPSVL LAYAICGIFIFFIMRAMGEMLYVEPSTGSFATFGHQYIHPMAGYITAWSNWFQWIIVG MSEIIAVGSYTKYWFPDLPAWIPGIVAMVILGAANLISVKSFGEFEFWFAMIKIVTII LMIIAGIGIIFFGFGNGGDAIGLSNLWSHGGFFAGGFSGFFFALSLVIAAYQGVELIG ITAGEAKDPQNTLRNAIQSIIWRILIFYIGAIFVIVTVYPWDELNSLGSPFVSTFSKI GITAAAGIINFVVITAAMSGCNSGIFSAGRMLYTLGVNGQAPKFFKKISRNGVPLYGT IAVLIGLAVGVVLNYIAPPKIFVYVYSASVLPGMIPWFIILISHIGFRKAKGAALDKH PFKMPFAPFTNYLTIAFLLMVLVGMWFNDDTRISLIVGVIFLALVVISYYVFGIGKRT QANLTKSEQAAE*" /label="ybxG CDS" gene 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /label="ybxG gene" downshifts 209529 /Source="Nicolas_upshifts" /id="D76" /incds=0 /nref=121 /ntot=219 /MaxReadThrough="2.32902" /MaxDrop="5.72049" /score="28.6554212" /energy="-8.5" /TU="NA" /idTUdmin="U140" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" promotor_-35 209567..209573 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 209587..209598 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 209588 /Source="Nicolas_upshifts" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="upshifts" CDS 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9016963" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9016963; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific SASP protein" /protein_id="NP_388089.1" /db_xref="EnsemblGenomes-Gn:BSU02070" /db_xref="EnsemblGenomes-Tr:CAB12001" /db_xref="GOA:P54379" /db_xref="InterPro:IPR020255" /db_xref="SubtiList:BG11504" /db_xref="UniProtKB/Swiss-Prot:P54379" /translation="MDVTLGYLRESLSNHLENEVCQRICKKMLAKRYANEEEFVKDLD DNEMSFLNHVLEKEIKYAQNEQDQKRAKELNEVYELLL*" /label="csgA CDS" gene 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /label="csgA gene" CDS 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388090.1" /db_xref="EnsemblGenomes-Gn:BSU02080" /db_xref="EnsemblGenomes-Tr:CAB12002" /db_xref="InterPro:IPR035314" /db_xref="SubtiList:BG11506" /db_xref="UniProtKB/Swiss-Prot:P54426" /translation="MGAIERSGYTFQPEFSVVRQNGAIHVYHQGEFVEEIEFEFNGEY PDHDLIEELVNHYCFEHEI*" /label="ybxH CDS" gene 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /label="ybxH gene" downshifts 210071 /Source="Nicolas_upshifts" /id="D77" /incds=0 /nref=17 /ntot=40 /MaxReadThrough="0.194030000000001" /MaxDrop="4.779" /score="29.4617878" /energy="-15.6" /TU="NA" /idTUdmin="U141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /EC_number="3.5.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14742199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14742199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported beta-lactamase" /protein_id="NP_388091.1" /db_xref="EnsemblGenomes-Gn:BSU02090" /db_xref="EnsemblGenomes-Tr:CAB12003" /db_xref="GOA:P54427" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR002137" /db_xref="InterPro:IPR012338" /db_xref="PDB:5E2F" /db_xref="SubtiList:BG11507" /db_xref="UniProtKB/Swiss-Prot:P54427" /translation="MKKWIYVVLVLSIAGIGGFSVHAASSAHEKHLNVSKMNVDDEFK DTDGTFILHDLQKDQTFVYNRKRANQRQTPQSTFKVVNALIGLQVKAVRDEYDVKRWD GVKREFESWNRDHTLGSAMRESAIWYYQALARDIGEERMKTWLHTLSYGNEDISGGID QFWLQSSLTISPLEQETFLEKLAKEELPFDKPVMKIVKRMMIQEEGDHYTLYGKTGTR LTDMGLGWFVGFIKTEHGSYVFVTNVDDSGTKAKNITVDILKKYGLITS*" /label="ybxI CDS" gene complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /label="ybxI gene" promotor_-10 complement(210941..210959) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(210949) /Source="Nicolas_upshifts" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(210970..210978) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 211033..211039 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 211054..211072 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 211060 /Source="Nicolas_upshifts" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="upshifts" CDS 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /EC_number="1.11.2.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10529095, 12519760, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10529095, 12519760, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid beta-hydroxylating cytochrome P450" /protein_id="NP_388092.1" /db_xref="EnsemblGenomes-Gn:BSU02100" /db_xref="EnsemblGenomes-Tr:CAB12004" /db_xref="GOA:O31440" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002401" /db_xref="InterPro:IPR036396" /db_xref="PDB:1IZO" /db_xref="PDB:2ZQJ" /db_xref="PDB:2ZQX" /db_xref="SubtiList:BG12729" /db_xref="UniProtKB/Swiss-Prot:O31440" /translation="MNEQIPHDKSLDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGK NFICMTGAEAAKVFYDTDRFQRQNALPKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSL MTPPHQKRLAELMTEEWKAAVTRWEKADEVVLFEEAKEILCRVACYWAGVPLKETEVK ERADDFIDMVDAFGAVGPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMA FHTQEDGSQLDSRMAAIELINVLRPIVAISYFLVFSALALHEHPKYKEWLRSGNSRER EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEF RPERFAEREENLFDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPEQS LHYSLARMPSLPESGFVMSGIRRKS*" /label="cypC CDS" gene 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /label="cypC gene" misc_feature 211404..211411 /Source="Nicolas_upshift_promotors" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 211414 /Source="Nicolas_upshifts" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 212338 /Source="Nicolas_upshifts" /id="D78" /incds=0 /nref=5 /ntot=36 /MaxReadThrough="2.65245" /MaxDrop="6.12325" /score="-7.42298703" /energy="-14.7" /TU="NA" /idTUdmin="U143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388093.1" /db_xref="EnsemblGenomes-Gn:BSU02110" /db_xref="EnsemblGenomes-Tr:CAB12005" /db_xref="SubtiList:BG12754" /db_xref="UniProtKB/Swiss-Prot:O31441" /translation="MKQKLLLSGLAVSTVGITSYLLKDPSNRQKAREFIHSMKMKITK QPDMETFPVDKAGHPDPQDIEDNKMVSEGSMYPVQYYDEKKK*" /label="ybyB CDS" gene complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /label="ybyB gene" downshifts complement(212405) /Source="Nicolas_upshifts" /id="D79" /incds=0 /nref=155 /ntot=247 /MaxReadThrough="3.63752" /MaxDrop="7.83539" /score="8.86703843" /energy="-12.4" /TU="U145" /idTUdmin="U145" /TUdmin="-387" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(212676..212694) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(212685) /Source="Nicolas_upshifts" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(212708..212714) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 212838..212845 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 212855 /Source="Nicolas_upshifts" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 212861..212880 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/amino acid transporter" /protein_id="NP_388094.2" /db_xref="EnsemblGenomes-Gn:BSU02120" /db_xref="EnsemblGenomes-Tr:CAB12006" /db_xref="GOA:Q45577" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12730" /db_xref="UniProtKB/Swiss-Prot:Q45577" /translation="MNQLHRRMGTFSLMMVGLGSMIGSGWLFGAWRAAQIAGPAAIIS WVIGMVVILFIALSYSELGSMFPEAGGMVKYTQYSHGSFIGFIAGWANWIAIVSVIPV EAVASVQYMSSWPWEWAKWTSGLVKNGTLTGEGLAFASVLLLIYFLLNYWTVNLFSKA NSLITIFKIIIPGLTIGALLFVGFHGENFTGGQSIAPNGWASVLTAVATSGIVFAFNG FQSPINMAGEAKNPGKSIPIAVVGSLFVATVIYVLLQIAFIGAVNPSDIAHGWSHLNF NSPFADLAIALNINWLVIVLYADAFVSPSGTGITYTATTSRMIYGMEKNKYMPSIFGK LHPIYGVPRQAMFFNLIVSFIFLFLFRGWGVLAEIISVATLISYITGPITVMTLRRTG KDLYRPLRLKGLNVIAPLGFIFASLVLYWARWPLTGQVLFIILIGLPIYFYYQAKAKW KGFGRNFKAGVWMVFYLLAMMVISYLGSDKFGGLNVIHYGWDMVLIAMVSLVFYVWAL KSGYQTEYLKDAKEINSQLLNGQSEAAAGKE*" /label="ybeC CDS" gene 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /label="ybeC gene" downshifts 214517 /Source="Nicolas_upshifts" /id="D80" /incds=0 /nref=183 /ntot=273 /MaxReadThrough="0.8051" /MaxDrop="6.79949" /score="24.7668372" /energy="-12.2" /TU="NA" /idTUdmin="U146" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10913081, 21966272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 21966272; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted glycerophosphoryl diester phosphodiesterase" /protein_id="NP_388095.1" /db_xref="EnsemblGenomes-Gn:BSU02130" /db_xref="EnsemblGenomes-Tr:CAB12007" /db_xref="GOA:P37965" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="PDB:5T91" /db_xref="PDB:5T9B" /db_xref="PDB:5T9C" /db_xref="SubtiList:BG10646" /db_xref="UniProtKB/Swiss-Prot:P37965" /translation="MRKNRILALFVLSLGLLSFMVTPVSAASKGNLLSPDRILTVAHR GASGYVPEHTILSYETAQKMKADFIELDLQMTKDGKLIVMHDEKLDRTTNGMGWVKDH TLADIKKLDAGSWFNEAYPEKAKPQYVGLKVPTLEEVLDRFGKHANYYIETKSPDTYP GMEEKLIASLQKHKLLGKHSKPGQVIIQSFSKESLVKVHQLQPNLPTVQLLEAKQMAS MTDAALEEIKTYAVGAGPDYKALNQENVRMIRSHGLLLHPYTVNNEADMHRLLDWGVT GVFTNYPDLFHKVKKGY*" /label="glpQA CDS" gene complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /label="glpQA gene" downshifts complement(214592) /Source="Nicolas_upshifts" /id="D81" /incds=0 /nref=61 /ntot=107 /MaxReadThrough="2.31368" /MaxDrop="7.76277" /score="9.56390732" /energy="-11.4" /TU="NA" /idTUdmin="U147" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(215505) /Source="Nicolas_upshifts" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(215514..215530) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(215539..215545) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8012593, 11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012593, 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate permease" /protein_id="NP_388096.1" /db_xref="EnsemblGenomes-Gn:BSU02140" /db_xref="EnsemblGenomes-Tr:CAB12008" /db_xref="GOA:P37948" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR005267" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR021159" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10645" /db_xref="UniProtKB/Swiss-Prot:P37948" /translation="MLNIFKPAPHIERLDDSKMDAAYKRLRLQVFIGIFIGYAGYYLL RKNFAFAIPYLQEQGFSKTELGLVLAAVSIAYGFSKFIMGMVSDRCNPRYFLATGLFL SAIVNILFVSMPWVTSSVTIMFIFMFINGWFQGMGWPPCGRTMAHWFSISERGTKMSI WNVAHNIGGGILAPLVTLGIAMFVTWKSVFFFPAIIAIIISFLIVLLVRDTPQSCGLP PIEEYRNDYPKHAFKNQEKELTTKEILFQYVLNNKFLWYIAFANVFVYFVRYGVVDWA PTYLTEAKGFSPEDSRWSYFLYEYAGIPGTILCGWISDRFFKSRRAPAGVLFMAGVFI AVLVYWLNPAGNPLVDNIALISIGFLIYGPVMLIGLQAIDLAPKKAAGTAAGLTGFFG YIGGSAFANAIMGFVVDRFNWNGGFIMLISSCILAIVFLALTWNTGKRAEHV*" /label="glpT CDS" gene complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /label="glpT gene" promotor_-35 216543..216552 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 216565..217191 /Source="Nicolas_S_feature" /locus_tag="new_234998_235624" /HighExp="S6, S8, S7, S5, BT, B36, G/S, C30, Pyr, B60" /AntisenseName="glpT" /AntisenseCor="-5.0958691169636701E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S81" promotor_-10 216565..216584 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 216565 /Source="Nicolas_upshifts" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216896..216968) /Source="Nicolas_S_feature" /locus_tag="new_235329_235401_c" /HighExp="G150, Oxctl, Paraq, S0, Diami, H2O2, Lbexp, dia5, dia0, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.042, 0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S82" promotor_no_box complement(216928..217028) /Source="Nicolas_upshift_promotors" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(216968) /Source="Nicolas_upshifts" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216970..217056) /Source="Nicolas_S_feature" /locus_tag="new_235403_235489_c" /HighExp="G150, Oxctl, S0, Diami, Lbexp, dia5, Paraq, dia0, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S83" promotor_-10 complement(217046..217065) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(217060) /Source="Nicolas_upshifts" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(217078..217085) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388097.1" /db_xref="EnsemblGenomes-Gn:BSU02150" /db_xref="EnsemblGenomes-Tr:CAB12009" /db_xref="GOA:O31442" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG12731" /db_xref="UniProtKB/Swiss-Prot:O31442" /translation="MDELDIAFFILPLGIMLLSIVGTCICKNPYLMPMLSLVISLVLT FTIFNQSFLGWAVVYSLVSLALSYITLIVVRKRKESGN*" /label="ybeF CDS" gene 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /label="ybeF gene" promotor_-35 217464..217471 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 217471 /Source="Nicolas_upshifts" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 217487..217506 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator with acetyltransferase domain" /protein_id="NP_388098.1" /db_xref="EnsemblGenomes-Gn:BSU02160" /db_xref="EnsemblGenomes-Tr:CAB12010" /db_xref="GOA:O31443" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12732" /db_xref="UniProtKB/Swiss-Prot:O31443" /translation="MKTRESSVGLKFRKFNRFYTNVLGFLNEHIYDSPFSLTETRILF EIYNTPNCTAKALQDKLGLDRGYVSRIVKQFEKEDLIYKQRSKDDARHHYIFVTETGK TIYKKLEEKANEQVELMLKVINQKEQHKLAEAMAEIEAILSQSLSARASEISIRDYFL SEDLQLLIEKQRQFYAEAHGWDDTFLAYLQETFDADIEKIWIAESGGKFAGSVGLVKH DEKTVQLRWFLVDADFRGRGLGTQLLEHLVAYCQDMKFDRIFLWTVSTMAEARPLYKK FGFRISEVKQEAPLWGQQLTEERWDLELS*" /label="ybfA CDS" gene 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /label="ybfA gene" CDS 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carboxylate transporter" /protein_id="NP_388099.1" /db_xref="EnsemblGenomes-Gn:BSU02170" /db_xref="EnsemblGenomes-Tr:CAB12011" /db_xref="GOA:O31444" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12733" /db_xref="UniProtKB/Swiss-Prot:O31444" /translation="MKRLHYAWIIVSVTFLILLAVQGVRLSFGAFVEPWERQFSIDRS TISLISTVSFIVYGISQPVIGRLVDKWGARAVLAWSALLTGVSIFLTYLVTSPWQLFL LYGLGVSLGVGGASNVAASVLVVNWFSKKRGLAFGIMEAGFGAGQMLLVPGSLMLIHW FSWKLTVVVLGLLLIVIVFPAALLMLRNNPSEKNTEPIGGLAASEKETAPKTTALSVA GMFRMRQFWFLIFPFLICGFTTVGLMDTHLIPFSHDHGFSTTVTSAAVSLLAGFNIAG ILLSGIVADRWSSRKILCILYAVRALSIVILIYSHEPYLLLAFAILFGLVDFATVAPT QMLATQYFQNYSIGLMIGWLSLAHQIGSALGAYVPGVIYTVTGEYTLAFYLSIGMLVL ASVMNVMLREPAAVTRDSAAVVDK*" /label="ybfB CDS" gene 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /label="ybfB gene" downshifts 219686 /Source="Nicolas_upshifts" /id="D82" /incds=0 /nref=57 /ntot=187 /MaxReadThrough="1.17226" /MaxDrop="5.55429" /score="12.1347284" /energy="-9.5" /TU="NA" /idTUdmin="U151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminal end)" /db_xref="EnsemblGenomes-Gn:BSU02180" /db_xref="EnsemblGenomes-Tr:CAB12012" /db_xref="GOA:O31445" /db_xref="PSEUDO:CAB12012.2" /db_xref="SubtiList:BG12734" /db_xref="UniProtKB/Swiss-Prot:O31445" /translation="MNHCLHSNTLAKIVCTVTLITLYFYFFSTRFNELIELAVQMFFA LIGLFWVFIVSPFSRKVQISERFKQKSENARIVGMIDFVLEQKYKKSISE*" /label="ybfEc CDS" gene complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /pseudo /label="ybfEc gene" downshifts complement(219784) /Source="Nicolas_upshifts" /id="D83" /incds=0 /nref=4 /ntot=189 /MaxReadThrough="2.49989" /MaxDrop="3.7302" /score="13.7144473" /energy="-12.6" /TU="U153" /idTUdmin="U153" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function YbfE (N-terminal fragment)" /db_xref="PSEUDO:SOX90538.1" /translation="MLNQLKVFFSEPLLTFKHTCQNRMYCDINNVILLFFQHSF*" /label="ybfEn CDS" gene complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /pseudo /label="ybfEn gene" S_feature complement(220016..220136) /Source="Nicolas_S_feature" /locus_tag="new_238449_238569_c" /HighExp="Lbexp, dia0, LBGexp, G150, Mt0, H2O2, dia5, M0t45, G135, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-" /TUshortPSig="0.899, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S84" promotor_-10 complement(220121..220139) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(220136) /Source="Nicolas_upshifts" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(220138..220210) /Source="Nicolas_S_feature" /locus_tag="new_238571_238643_c" /HighExp="Lbexp, dia0, LBGexp, HPh, G150, H2O2, dia5, Mt0, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S85" promotor_-35 complement(220156..220161) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388101.1" /db_xref="EnsemblGenomes-Gn:BSU02190" /db_xref="EnsemblGenomes-Tr:CAB12013" /db_xref="GOA:O31446" /db_xref="SubtiList:BG12735" /db_xref="UniProtKB/Swiss-Prot:O31446" /translation="MKNDQIVFEKTKNIAHDINQMQNQQEIIDYLFRQDSLTLNQLKH YYSEPSLPLQFLVKVAVLCMFISMTLASFLFIQAKEVFTNTILSDISPAVFSIFTVIC IFMTYTKIIKKGNKNKGKASLNQRSEFYEKNKLINTILYKKYKMDQQNIQANKHTASD NEDSMNFSAVLNHVLTISKNDKELLGYLDTRDNAMLSQLKAYFSTRPFSLPHYMSLMF CGSIIVVYATSLFSGQINYIDIPHIFIFLLLIIFLKILIDLIKLLNISRKGQLHTVLH FAQRAEYLRMRGVIDFILTERYNKKIM*" /label="ybfF CDS" gene complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /label="ybfF gene" S_feature complement(221123..221210) /Source="Nicolas_S_feature" /locus_tag="new_239556_239643_c" /HighExp="LBGexp, Lbexp, G150, dia5, dia0, G135, Oxctl, H2O2, Mt0, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S86" CDS complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pepdidoglycan binding protein" /protein_id="NP_388102.1" /db_xref="EnsemblGenomes-Gn:BSU02200" /db_xref="EnsemblGenomes-Tr:CAB12014" /db_xref="GOA:O31447" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG12736" /db_xref="UniProtKB/Swiss-Prot:O31447" /translation="MVDEMVLITQQWLNDTYSGKHGYNPVEESGKTGWDTIYGLTRAL QIELGISEPADNFGPTTQRLFKPLKRQAPDSKPSNMNFILQGALWCKGFNPGGFTGVF YEKTENAVKEFQKAAGLTTQDGIVTTLIMKALLDMSAFKLVSGGDSRIRQIQQNLNRD YNDYIGLMPCDGLYGRDTNKALIYALQKEEGMSTSVANGFFGNGTTSLCPTLTPGDSR TGFVLIVQYALYCNGKSFDPGEFDGKYGVGVVSAVKAFQEFMCLPQTGYADMPTIKAL LSSSGDTTRTASACDTATIITAEKAQTLRNNGYKTVGRYLTGNVRTSSGLTSKALTSK ELAVILDAGLKVFPIYQDGGYESSYFVKDQGTRDAYSAASAARRLGFPSGTTIYFAVD FDAYDYEVTDKIIPYFQEIKSAFTKMQTFSTAPKYEIGVYGPRNICIRTSEAGLTKYS FVANMSTGFSGNLGYPMPNNWAFDQFYEGTIGSGSGSIGIDKDGYSGRDSGASNVNPP SDPVYDARLRTLTDILSTIPALENLTSLANAMFEFDTTETIFTSPELDIILSTSLLAT IPSEGSPNTITITNGKPGAYITGLLGDTQTSLTASQIDSYQNLLNSLSLSVRNGYLEV YVNPTAESLNIQIKIYTPDIPVGDNVTTGLTTTITFKIKTYKGVPVTSPESELALDWP SYDQYLFPVVGVAALLLIGNMGSDLTNNKGVKVATALSAMLLAIFAYYTS*" /label="ybfG CDS" gene complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /label="ybfG gene" misc_feature complement(223444..223462) /Source="Nicolas_upshift_promotors" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(223456) /Source="Nicolas_upshifts" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388103.1" /db_xref="EnsemblGenomes-Gn:BSU02210" /db_xref="EnsemblGenomes-Tr:CAB12015" /db_xref="GOA:O31448" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12737" /db_xref="UniProtKB/Swiss-Prot:O31448" /translation="MNIQRETSGHIAAIVTILIWGTTFISTKVLLADFSPMEILFYRF LMGFIALILVRPNMIPFRNWRQELLFAGAGLFGVTLYFLLENIALTYTYASNVGMIVS IIPMITAVLAHFLLEGEKLRLTFLIGFISALIGLLLITFNGNVVLRLNPLGDIMAAGA ALVFGGYSIFMKKLSAYEYHIIELTQRVFLYGLLFMVPALFLFDFHFDLSRFSSASNI LNMLFLGIGASALCFATWNYSVGVLGAVKSSAYIYMVPVITIAASVLILHENMTWIAL LGGALTLLGLYISELKPKAKLLENGCKMDA*" /label="ybfH CDS" gene complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /label="ybfH gene" CDS complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family, cupin family)" /protein_id="NP_388104.1" /db_xref="EnsemblGenomes-Gn:BSU02220" /db_xref="EnsemblGenomes-Tr:CAB12016" /db_xref="GOA:O31449" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12738" /db_xref="UniProtKB/Swiss-Prot:O31449" /translation="MQNETRTLQLDPHLHIEAYRFKGIMQKFPNHFHDYYVIGFIEKG QRYLACQDQEYIINPGDLLLFNPRDTHSCEQIDGRTLDYRCINVMPDIMEKAVKEITG SGHLPYFSQHVLFRHELTASLQELHILISEEKQALRKEELFLHLLEELIRHYSDVTFL SSVPEPSDEVKMVCEFLEEHYAENVTLNDLSELTGWSKYHLLRSFTKQKGITPNSYME TIRINQAKKLLEQGVRPIDAAFQTGFSDQSHMTKFFKRQVGLTPKQYMKIFEKELHR* " /label="ybfI CDS" gene complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /label="ybfI gene" misc_feature complement(225255..225274) /Source="Nicolas_upshift_promotors" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(225262) /Source="Nicolas_upshifts" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 225402..225405 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 225420..225439 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 225425 /Source="Nicolas_upshifts" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="upshifts" CDS 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /EC_number="2.1.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496533; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase 2" /protein_id="NP_388105.1" /db_xref="EnsemblGenomes-Gn:BSU02230" /db_xref="EnsemblGenomes-Tr:CAB12017" /db_xref="GOA:P39771" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005862" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10924" /db_xref="UniProtKB/Swiss-Prot:P39771" /translation="MYQSKKVLLLGSGELGKEVVIEAQRLGVQTVAVDSYEHAPAMQV AHNSYVVDMLDPEQIRTIIEKENPDLIVPEVEAIATDELLKLEEEGFHVIPNARAAKL TMDREGIRRLAAETLGLATAGYEFANTYDEFIQAAAQIGFPCVVKPLMSSSGKGQSVC RSEADLESCWETAMEGGRVKNGRVIVEEFIPFESEITLLTVRAVNGTAFCEPIGHVQK DGDYIESWQPHDMTEQQIEEAKHIAKTITDELGGYGLFGVELFLAKDRVYFSEVSPRP HDTGLVTLVTQNLSEFALHVRAILGFPITEITQLSPGASRPLKAPEELADYTVEGLEN ALAVPKTQVRVFGKPITKAGRRMAVALSAADSVETARENAKKALDQLILK*" /label="purT CDS" gene 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /label="purT gene" downshifts 226594 /Source="Nicolas_upshifts" /id="D84" /incds=0 /nref=100 /ntot=189 /MaxReadThrough="2.6996" /MaxDrop="5.22319" /score="39.2561117" /energy="-15.1" /TU="NA" /idTUdmin="U155" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 226674..226679 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-35" upshifts 226688 /Source="Nicolas_upshifts" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="upshifts" promotor_-10 226694..226712 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-10" promotor_-35 226728..226735 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 226750..226769 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 226750 /Source="Nicolas_upshifts" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 226757..227698 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15205417, 15375126, 21819557, 25666135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular glutamyl-endopeptidase" /protein_id="NP_388106.1" /db_xref="EnsemblGenomes-Gn:BSU02240" /db_xref="EnsemblGenomes-Tr:CAB12018" /db_xref="GOA:P39790" /db_xref="InterPro:IPR000126" /db_xref="InterPro:IPR001254" /db_xref="InterPro:IPR008256" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR018114" /db_xref="InterPro:IPR028301" /db_xref="SubtiList:BG10690" /db_xref="UniProtKB/Swiss-Prot:P39790" /translation="MKLVPRFRKQWFAYLTVLCLALAAAVSFGVPAKAAENPQTSVSN TGKEADATKNQTSKADQVSAPYEGTGKTSKSLYGGQTELEKNIQTLQPSSIIGTDERT RISSTTSFPYRATVQLSIKYPNTSSTYGCTGFLVNPNTVVTAGHCVYSQDHGWASTIT AAPGRNGSSYPYGTYSGTMFYSVKGWTESKDTNYDYGAIKLNGSPGNTVGWYGYRTTN SSSPVGLSSSVTGFPCDKTFGTMWSDTKPIRSAETYKLTYTTDTYGCQSGSPVYRNYS DTGQTAIAIHTNGGSSYNLGTRVTNDVFNNIQYWANQ*" /label="mpr CDS" gene 226757..227698 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /label="mpr gene" CDS 227661..228059 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388107.1" /db_xref="EnsemblGenomes-Gn:BSU02250" /db_xref="EnsemblGenomes-Tr:CAB12019" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR019730" /db_xref="SubtiList:BG12739" /db_xref="UniProtKB/Swiss-Prot:O31451" /translation="MYSTIFNIGQINKYSKLAIFMSILFLCGCSSQTHSSQKETTIPV TLHVEDAKGLPVEGVQVTIVKAPSSDEEPSTEIGEILGKTDKNGDIKWDTGRKGDYSV ALTKGETSVTHHISLTEDKKDHAIPLVFKE*" /label="ybfJ CDS" gene 227661..228059 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /label="ybfJ gene" promotor_-10 complement(227753..227767) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(227763) /Source="Nicolas_upshifts" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(227783..227788) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 228046 /Source="Nicolas_upshifts" /id="D85" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.50775" /MaxDrop="5.06025" /score="29.4582027" /energy="-15.4" /TU="U156" /idTUdmin="U157" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 228115..228122 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 228137..228156 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 228150..228224 /Source="Nicolas_S_feature" /locus_tag="new_246583_246657" /HighExp="Cold, LoTm, S0, aero, ferm, T-4.40H, nit, T-5.40H, T-0.40H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S87" upshifts 228150 /Source="Nicolas_upshifts" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" CDS 228225..229115 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11389736, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11389736, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enantioselective carboxylesterase" /protein_id="NP_388108.1" /db_xref="EnsemblGenomes-Gn:BSU02260" /db_xref="EnsemblGenomes-Tr:CAB12020" /db_xref="GOA:O31452" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:4CCY" /db_xref="SubtiList:BG12740" /db_xref="UniProtKB/Swiss-Prot:O31452" /translation="MIQDSMQFAAVESGLRFYQAYDQSLSLWPIESEAFYVSTRFGKT HIIASGPKDAPSLILLHGGLFSSAMWYPNIAAWSSQFRTYAVDIIGDKNKSIPSAAME TRADFAEWMKDVFDSLGLETAHLAGLSLGGSHIVNFLLRAPERVERAVVISPAEAFIS FHPDVYKYAAELTGARGAESYIKWITGDSYDLHPLLQRQIVAGVEWQDEQRSLKPTEN GFPYVFTDQELKSIQVPVLLMFGEHEAMYHQQMAFERASVLVPGIQAEIVKNAGHLLS LEQPEYVNQRVLSFLCGGIK*" /label="cesB CDS" gene 228225..229115 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /label="cesB gene" promotor_-35 228459..228466 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 228475 /Source="Nicolas_upshifts" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 228480..228498 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 229116..229310 /Source="Nicolas_S_feature" /locus_tag="new_247549_247743" /HighExp="Cold, LBGstat, Paraq, Oxctl, H2O2, dia15, G135, Diami, Lbexp, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.867, 1" /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S88" CDS 229311..229844 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /EC_number="2.7.8.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 15743965, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 15743965, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine synthase" /protein_id="NP_388109.1" /db_xref="EnsemblGenomes-Gn:BSU02270" /db_xref="EnsemblGenomes-Tr:CAB12021" /db_xref="GOA:P39823" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004533" /db_xref="SubtiList:BG11012" /db_xref="UniProtKB/Swiss-Prot:P39823" /translation="MNYIPCMITIGNFICGLLAIHSLLYHNIHSAVLFIFTGMFLDFF DGMAARKLNAVSDMGRELDSFADLVTFGVAPSMLAYSVALYTLPFIGILCALTYSICG MLRLSKFNIEQSKLPTFIGMPIPFAGMCLVILSFTYNPILLAIGTCGLSYLMVSKIKF PHFKKHAAENLESGRWN*" /label="pssA CDS" gene 229311..229844 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /label="pssA gene" CDS 229835..230323 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 14762009, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane phosphatase" /protein_id="NP_388110.1" /db_xref="EnsemblGenomes-Gn:BSU02280" /db_xref="EnsemblGenomes-Tr:CAB12022" /db_xref="GOA:O31453" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG12741" /db_xref="UniProtKB/Swiss-Prot:O31453" /translation="MELVQQLIADYGYLAIFLMLVLGIVGLPIPDEVMMTVVGYFTHT DVLNYELSILISFVGALLGMLISYMIGRKAGRPFIDKYGKWVGLKEKRMMKVEKWMKK YGPYSLILGYFIPGVRHVTCYFSGIGKMDLKTYVAFAAIGAFLWCFVFITIGRVIGII HV*" /label="ybfM CDS" gene 229835..230323 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /label="ybfM gene" CDS 230316..231107 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /EC_number="4.1.1.65" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 9422599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 9422599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine decarboxylase; 32 kDa precursor processed into a 29 kDa protein" /protein_id="NP_388111.1" /db_xref="EnsemblGenomes-Gn:BSU02290" /db_xref="EnsemblGenomes-Tr:CAB12023" /db_xref="GOA:P39822" /db_xref="InterPro:IPR003817" /db_xref="InterPro:IPR033177" /db_xref="InterPro:IPR033178" /db_xref="SubtiList:BG11013" /db_xref="UniProtKB/Swiss-Prot:P39822" /translation="MFNTAVKILYRSLIELTNHRLSSYLIKGFCESKISKPVIPLFSK HFRLNWDDVDGTAADYGSLSELFIRQINLERRPVSKEAHAVVSPVDGVVQTVGIINPN QTFTVKGKDYSFAELTGCKSADHQYNGGYFVVLYLSPRHYHRFHSPISCRYQKLAELG NRSYPVNQLGLKYGKDVLSKNYRFVYELNSGSRNVLMIPVGAMNINSIVQTNTRTELE IGEELGYFSFGSTVILVFEKDAFQPSAHLAEGQEVQVGELIGYEE*" /label="psd CDS" gene 230316..231107 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /label="psd gene" downshifts 231082 /Source="Nicolas_upshifts" /id="D86" /incds=0 /nref=101 /ntot=236 /MaxReadThrough="3.18138" /MaxDrop="4.25536" /score="-2.98360164" /energy="-8" /TU="U159" /idTUdmin="U160" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 231162..231440 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388112.1" /db_xref="EnsemblGenomes-Gn:BSU02300" /db_xref="EnsemblGenomes-Tr:CAB12024" /db_xref="SubtiList:BG12742" /db_xref="UniProtKB/Swiss-Prot:O31454" /translation="MEKQIISWITDYQNTGDEAVLRQVREVCWPIVEAVLQEKVMDDE QANNLREKGIERFPFIISKYQADVQLPVETFLQNTYRFYFHQVMRESS*" /label="ybfN CDS" gene 231162..231440 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /label="ybfN gene" promotor_-35 231483..231492 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 231501 /Source="Nicolas_upshifts" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 231505..231520 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 231546..232886 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_388113.1" /db_xref="EnsemblGenomes-Gn:BSU02310" /db_xref="EnsemblGenomes-Tr:CAB12025" /db_xref="GOA:O31455" /db_xref="InterPro:IPR007815" /db_xref="SubtiList:BG12743" /db_xref="UniProtKB/Swiss-Prot:O31455" /translation="MKRMIVRMTLPLLIVCLAFSSFSASARAASEEKYWDHWIERHAQ PLDASNASNKDLRFLKKVLKGKRIVQLGETTHGAGEINATKVRMIKYLHEELGYDVLA FESGFPDTNASYLNMDQLTPKSTMKNSIYAVWHTEDVVELFDYMKEQKEKGDPLILTG FDIQSMKNSFNVAATQWVKAVDPEKAELLSQSENDFSTLVTDSNTFDEFSQKKEKLVK NYQKLIKFTKTHASELKENLPKEPKAYEMFMHSLQLRIDVMETYMLEEMKEKLEEYPE NIEDFSFFMRDRMMAEQFQWVADTLYPKKKIIVWGHNYHLRKQNTKMIKDWVQLNGPN MGDYLPERLKKQTYTIGIYAYSGASLDSSDNKTVKPVTSPPPSGSLEALLKAADRPAV FVDFLHTKNKKGTSWMYTPRTALYWGYMEEQMILKEQYDGVIWLEHITPSVIIK*" /label="ybfO CDS" gene 231546..232886 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /label="ybfO gene" downshifts 232886 /Source="Nicolas_upshifts" /id="D87" /incds=0 /nref=12 /ntot=60 /MaxReadThrough="3.64301" /MaxDrop="6.34998" /score="14.4442651" /energy="-13.3" /TU="U161" /idTUdmin="U162" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" upshifts 232952 /Source="Nicolas_upshifts" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="upshifts" misc_feature 232955..232974 /Source="Nicolas_upshift_promotors" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 232994..233881 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388114.1" /db_xref="EnsemblGenomes-Gn:BSU02320" /db_xref="EnsemblGenomes-Tr:CAB12026" /db_xref="GOA:O31456" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12744" /db_xref="UniProtKB/Swiss-Prot:O31456" /translation="MYYEKAVQKTINWIESHLHEQISNEDIVNVSSFSKFHFHRIFQK EVGMSVASYIRLRRLANAAAALLYTDHRIIDIALYYQFESQEAFTRTFKKMYHMPPGA YRTFMKRFTSKKEESYMEKKMKGWVLSGSHPFQFEMGIDRENVHQGKASGYLKSTMVQ DIGEFATMMQQFKADRYLGKRLRLSSFIKTKGVQHFASLWMRVDSAADDVLQFDNMSN RPITGTTNWNHYAIVLDVPENSAVISFGVQLSGPGQVWMDHVVFEEVDESVPSTNLEM PGELLDEPVNLSFEEELQK*" /label="ybfP CDS" gene 232994..233881 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /label="ybfP gene" S_feature 233882..234025 /Source="Nicolas_S_feature" /locus_tag="new_252315_252458" /HighExp="T0.30H, T-1.40H, T0.0H, T-1.10H, Salt, aero, ferm, T-0.40H, T-2.40H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.838, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S89" promotor_-35 233997..234004 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 234018..234037 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 234027 /Source="Nicolas_upshifts" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 234081..235049 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with rhodanese domain" /protein_id="NP_388115.1" /db_xref="EnsemblGenomes-Gn:BSU02330" /db_xref="EnsemblGenomes-Tr:CAB12027" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR020936" /db_xref="InterPro:IPR022111" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG12745" /db_xref="UniProtKB/Swiss-Prot:O31457" /translation="MEKQYRVLLYYKYVPIEDPEAFREQHLAFCKELGLLGRILVSSE GINGTVSGTVEQTEKYMETMKADPRFADMVFKIDEAEGHAFKKIFVRHKKELVTLRLE DDVDPNETTGQHLKPAEFYEKMQDPNTIVIDARNDYEYDLGHFRGAVRPDIEAFRELP EWIEEHKDMLEGKKILTYCTGGVRCEKFSGWLVKQGFEDVAQLDGGIVTYGKDPEVQG KLWDGQCYVFDERISVPVNRVEHVIVGKDYFTGEPCERYVNCANPSCNKKMICTPENE YKYMRSCSHECRTNPRNLYVKEHNMTEEEVNARLAAIETEDHAAAE*" /label="ybfQ CDS" gene 234081..235049 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /label="ybfQ gene" promotor_-10 complement(234903..234921) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(234920) /Source="Nicolas_upshifts" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(234937..234942) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 235046 /Source="Nicolas_upshifts" /id="D88" /incds=0 /nref=238 /ntot=271 /MaxReadThrough="2.06825" /MaxDrop="7.49655" /score="4.11635522" /energy="-7.8" /TU="U163" /idTUdmin="U161" /TUdmin=4 /isTUend="TRUE" /label="downshifts" downshifts complement(235085) /Source="Nicolas_upshifts" /id="D89" /incds=0 /nref=59 /ntot=147 /MaxReadThrough="0.54212" /MaxDrop="6.33244" /score="2.56774646" /energy="-7.5" /TU="NA" /idTUdmin="U165" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(235085..236329) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7751298, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7751298, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/glutamate symport protein" /protein_id="NP_388116.1" /db_xref="EnsemblGenomes-Gn:BSU02340" /db_xref="EnsemblGenomes-Tr:CAB12028" /db_xref="GOA:P39817" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11015" /db_xref="UniProtKB/Swiss-Prot:P39817" /translation="MKKLIAFQILIALAVGAVIGHFFPDFGMALRPVGDGFIRLIKMI VVPIVFSTIVIGAAGSGSMKKMGSLGIKTIIWFEVITTLVLGLGLLLANVLKPGVGLD LSHLAKKDIHELSGYTDKVVDFKQMILDIIPTNIIDVMARNDLLAVIFFAILFGVAAA GIGKASEPVMKFFESTAQIMFKLTQIVMVTAPIGVLALMAASVGQYGIELLLPMFKLV GTVFLGLFLILFVLFPLVGLIFQIKYFEVLKMIWDLFLIAFSTTSTETILPQLMDRME KYGCPKRVVSFVVPSGLSLNCDGSSLYLSVSCIFLAQAFQVDMTLSQQLLMMLVLVMT SKGIAAVPSGSLVVLLATANAVGLPAEGVAIIAGVDRVMDMARTGVNVPGHAIACIVV SKWEKAFRQKEWVSANSQTESI*" /label="gltP CDS" gene complement(235085..236329) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /label="gltP gene" promotor_-10 complement(236363..236381) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236372) /Source="Nicolas_upshifts" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(236392..236400) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(236400..236418) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236416) /Source="Nicolas_upshifts" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(236434..236439) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(236474..238369) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /EC_number="2.7.1.193" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10627040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucosamine-specific enzyme IICBA component" /protein_id="NP_388117.1" /db_xref="EnsemblGenomes-Gn:BSU02350" /db_xref="EnsemblGenomes-Tr:CAB12029" /db_xref="GOA:P39816" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11014" /db_xref="UniProtKB/Swiss-Prot:P39816" /translation="MFKKAFQILQQLGRALMTPVAVLPAAGLLLRFGDKDLLNIPIIK DAGGVVFDNLPLIFAVGVAIGLAGGEGVAGLAAVIGYLILTVTLDNMGKLLGLQPPYE GAEHLIDMGVFGGIIIGLLAAYLYKRFSSIELHPVLGFFSGKRFVPIITSVSSLVIGV IFSFVWPLIQNGINAASSLIADSTVGLFFYATIYRLLIPFGLHHIFYTPFYFMMGEYT DPSTGNTVTGDLTRFFAGDPTAGRFMMGDFPYMIFCLPAVALAIIHTARPEKKKMISG VMISAALTSMLTGITEPVEFSFLFVAPVLYLINSILAGVIFVVCDLFHVRHGYTFSGG GIDYVLNYGLSTNGWVVIPVGIVFAFIYYYLFRFAILKWNLKTPGRETDEDGQNEEKA PVAKDQLAFHVLQALGGQQNIANLDACITRLRVTVHQPSQVCKDELKRLGAVGVLEVN NNFQAIFGTKSDALKDDIKTIMAGGVPATAAALDTVTDKPLKPDSDETFIYPIKGETV SLGDVPDQVFSEKMMGEGFAIIPSEGKVVAPADGEIVSIFPTKHAIGFMSAGGTEILI HVGIDTVKLNGEGFEAHVTSGQAVKQGELLLTFDLNYIKQHAASAITPVIFTNTSEED LKHIQMK*" /label="gamP CDS" gene complement(236474..238369) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /label="gamP gene" downshifts complement(236490) /Source="Nicolas_upshifts" /id="D90" /incds=0 /nref=56 /ntot=192 /MaxReadThrough="1.9947" /MaxDrop="6.51864" /score="5.87664177" /energy="-12.1" /TU="NA" /idTUdmin="U168" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" misc_feature 238235..238254 /Source="Nicolas_upshift_promotors" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 238252 /Source="Nicolas_upshifts" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(238390..239139) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /EC_number="3.5.99.6" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:23667565, 27002132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 27002132; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate deaminase" /protein_id="NP_388118.1" /db_xref="EnsemblGenomes-Gn:BSU02360" /db_xref="EnsemblGenomes-Tr:CAB12030" /db_xref="GOA:O31458" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="SubtiList:BG12746" /db_xref="UniProtKB/Swiss-Prot:O31458" /translation="MKILIAEHYEELCKLSAAIIKEQIQAKKDAVLGLATGSTPVGLY KQLISDYQAGEIDFSKVTTFNLDEYAGLSPSHPQSYNHFMHEHLFQHINMQPDHIHIP QGDNPQLEAACKVYEDLIRQAGGIDVQILGIGANGHIGFNEPGSDFEDRTRVVKLSES TIQANARFFGGDPVLVPRLAISMGIKTIMEFSKHIVLLASGEEKADAIQKMAEGPVTT DVPASILQKHNHVTVIADYKAAQKLKSASFS*" /label="gamA CDS" gene complement(238390..239139) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /label="gamA gene" S_feature 239112..239293 /Source="Nicolas_S_feature" /locus_tag="new_257545_257726" /HighExp="H2O2, T1.30H, G135, dia15, G150, G180, LBGstat, T2.0H, T0.30H, M9-stat" /AntisenseName="nagBB" /AntisenseCor="0.458837556034909" /AntisenseRegPval="-14.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S90" S_feature complement(239140..239210) /Source="Nicolas_S_feature" /locus_tag="new_257573_257643_c" /HighExp="S1, Diami, MG 5, MG t5, dia5, MG 15, MG 10, LPhT, Paraq, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S91" promotor_-10 complement(239199..239218) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(239214) /Source="Nicolas_upshifts" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(239234..239241) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 239280..239287 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 239295 /Source="Nicolas_upshifts" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 239300..239319 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 239358..240065 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23667565, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator-GlcN6P (GntR family)" /protein_id="NP_388119.1" /db_xref="EnsemblGenomes-Gn:BSU02370" /db_xref="EnsemblGenomes-Tr:CAB12031" /db_xref="GOA:O31459" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12747" /db_xref="UniProtKB/Swiss-Prot:O31459" /translation="MTALYSVIKFKIIELIKSGKYQANDQLPTESEFCEQYDVSRTTV RLALQQLELEGYIKRIQGKGTFVSAAKIQTPIPHKITSFAEQMRGLRSESKVLELVVI PADHSIAELLKMKENEPVNKLVRVRYAEGEPLQYHTSYIPWKAAPGLAQEECTGSLFE LLRTKYNIEISRGTESIEPILTDETISGHLLTNVGAPAFLSESLTYDKNEEVVEYAQI ITRGDRTKFTVEQSYHS*" /label="gamR CDS" gene 239358..240065 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /label="gamR gene" promotor_-35 240031..240032 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240048..240062 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240058 /Source="Nicolas_upshifts" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="upshifts" CDS 240099..240374 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12897008, 23667565" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (B. subtilis-specific)" /protein_id="NP_388120.1" /db_xref="EnsemblGenomes-Gn:BSU02380" /db_xref="EnsemblGenomes-Tr:CAB12032" /db_xref="GOA:O31460" /db_xref="InterPro:IPR012867" /db_xref="SubtiList:BG12748" /db_xref="UniProtKB/Swiss-Prot:O31460" /translation="MFLFTNGKVLWGAVIAAFILSIVFYPFLPTQMPIHYDVANSPDL TVNKLAGTVMLPVLMVVFAWARKINWQFVFAVYILLICHIVVLCLAL*" /label="ybgB CDS" gene 240099..240374 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /label="ybgB gene" promotor_-10 complement(240157..240175) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(240163) /Source="Nicolas_upshifts" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(240190..240196) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 240366 /Source="Nicolas_upshifts" /id="D91" /incds=0 /nref=20 /ntot=130 /MaxReadThrough="2.42422" /MaxDrop="3.75723" /score="4.58454735" /energy="-9.4" /TU="NA" /idTUdmin="U169" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 240417..240421 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240437..240456 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240443 /Source="Nicolas_upshifts" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="upshifts" S_feature 240454..240582 /Source="Nicolas_S_feature" /locus_tag="new_258887_259015" /HighExp="T2.30H, S5, T2.0H, T1.30H, M9-stat, T3.0H, T3.30H, S4, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S92" CDS 240583..241653 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15060025, 15102328, 20332210, 23429746" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15060025, 15102328, 20332210, 23429746; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucine-valine aminotransferase / aromatic amino acid aminotransferase" /protein_id="NP_388121.1" /db_xref="EnsemblGenomes-Gn:BSU02390" /db_xref="EnsemblGenomes-Tr:CAB12033" /db_xref="GOA:O31461" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG12749" /db_xref="UniProtKB/Swiss-Prot:O31461" /translation="MNKLIEREKTVYYKEKPDPSSLGFGQYFTDYMFVMDYEEGIGWH HPRIAPYAPLTLDPSSSVFHYGQAVFEGLKAYRTDDGRVLLFRPDQNIKRLNRSCERM SMPPLDEELVLEALTQLVELEKDWVPKEKGTSLYIRPFVIATEPSLGVKASRSYTFMI VLSPVGSYYGDDQLKPVRIYVEDEYVRAVNGGVGFAKTAGNYAASLQAQRKANELGYD QVLWLDAIEKKYVEEVGSMNIFFVINGEAVTPALSGSILSGVTRASAIELIRSWGIPV REERISIDEVYAASARGELTEVFGTGTAAVVTPVGELNIHGKTVIVGDGQIGDLSKKL YETITDIQLGKVKGPFNWTVEV*" /label="ilvE CDS" gene 240583..241653 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /label="ilvE gene" downshifts 241642 /Source="Nicolas_upshifts" /id="D92" /incds=0 /nref=124 /ntot=245 /MaxReadThrough="1.34575" /MaxDrop="6.88046" /score="13.1364544" /energy="-9.4" /TU="NA" /idTUdmin="U172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(241690..243102) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid permease" /protein_id="NP_388122.1" /db_xref="EnsemblGenomes-Gn:BSU02400" /db_xref="EnsemblGenomes-Tr:CAB12034" /db_xref="GOA:O31462" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12750" /db_xref="UniProtKB/Swiss-Prot:O31462" /translation="MNSAHNKNETTFQRSMKSRHLFMLSLGGVIGTGLFLSSGYTIQQ AGPAGTILAYLVGAGIVYLVMLCLGELSVAMPVTGAFHTYAAKYIGPGTGFTVAWLYW LTWTVALGSEFTAAGLLMQRWFPHTSVWMWSAVFALFIFLLNAFSVKFFAESEFWFSS IKVLAIVLFILLGGSAMFGIIPIKGGEAAPMLSNFTAEGGLFPNGFVPILMTMLSVNF AFSGTELIGIAAGESVDPDKTIPKAIKTTVWRLSLFFVGTIFVLSGLIPIQDAGVIKS PFVAVFDRVGVPYAADIMNFVILTAILSAANSGLYASSRMLWSLSKEKTLHPTFAKLT SKGTPFNALVFSMIGGILSLLSSVFAPDTVYVVLVSISGFAVVVVWMGIAASQFMFRK RYIEAGNKVTDLKYRTPLYPFVPIAAFLLCLASVVGIAFDPNQRIALYCGVPFMAICY AIYYVKNRKSQPAADMTHSK*" /label="ybgF CDS" gene complement(241690..243102) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /label="ybgF gene" downshifts complement(241707) /Source="Nicolas_upshifts" /id="D93" /incds=0 /nref=43 /ntot=166 /MaxReadThrough="0.37503" /MaxDrop="5.92001" /score="6.94246417" /energy="-9.4" /TU="NA" /idTUdmin="U173" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(243103..243214) /Source="Nicolas_S_feature" /locus_tag="new_261536_261647_c" /HighExp="BMM, S1, MG 45, MG 60, UNK1, MG t5, MG 10, MG 90, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S93" promotor_-10 complement(243187..243206) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(243214) /Source="Nicolas_upshifts" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(243221..243228) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(243223..244170) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11267663, 15995196, 17264075; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homocysteine methylase using (R,S)AdoMet" /protein_id="NP_388123.1" /db_xref="EnsemblGenomes-Gn:BSU02410" /db_xref="EnsemblGenomes-Tr:CAB12035" /db_xref="GOA:O31463" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR017226" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG12751" /db_xref="UniProtKB/Swiss-Prot:O31463" /translation="MNPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEE PELIKQVHTDYFAAGADCAITASYQSTFEGFAARGLSEAEARRLIELSVSIAAEARDE FWSLEENRLNRPKPIIAASIGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEA GADVLACETIPCLTEAKAIVRLLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDE HRQIAALGINCTPLQHIPSLIEELKKNTSKPIIVYPNSGEQYDPETKTWNGAACAESY GASARTWHEKGARLIGGCCRTKPENIQEIAAWARSLKTT*" /label="ybgG CDS" gene complement(243223..244170) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /label="ybgG gene" promotor_-10 complement(244208..244227) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-10" upshifts complement(244225) /Source="Nicolas_upshifts" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="upshifts" promotor_-35 complement(244242..244249) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-35" CDS complement(244299..245735) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 15995196, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine transporter" /protein_id="NP_388124.2" /db_xref="EnsemblGenomes-Gn:BSU02420" /db_xref="EnsemblGenomes-Tr:CAB12036" /db_xref="GOA:O31464" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12752" /db_xref="UniProtKB/Swiss-Prot:O31464" /translation="MQQILEHIVGIANDLLWSKLLIVLLLSFGIYFTFRLKFLQVRML KEMVRVLREGAASRSKNSISPFQAFCISMAARVGTGNITGIAIAIALGGPGAIFWMWI IAIIGSASSFVESTLAQIYKVKDVNGFRGGPAYYMEKGLNKRWMGALFAVLITLSFGI VFNSVQSNTVSLAFENAFGTNRLTLGLILIAVFGTIIFGGVKRIAKLAESIVVVLAVL YIGVAFFVIFSNITQLPGVLALIVKNAFGFDQAAGGALGAALMQGVRRGIFSNEAGMG SAPNAAATATTSHPVKQGLIQAFGVLTDTLVICTSTAFIILFSDAYHTPGLSGIALTQ ASLSSHVGSWASGFLAILILLFGFCALIGNYYYGETNIGFLNKSKKLIFVYRIGVLAM IVFGCVAKVQLVWDLADLFMGLMVIVNLIAIFLLSKVVFTALKDYTRQKKAGKDPVFY KDVLKNHNGIECWPVSDTKTDTHNKQIS*" /label="glnT CDS" gene complement(244299..245735) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /label="glnT gene" downshifts complement(244314) /Source="Nicolas_upshifts" /id="D94" /incds=0 /nref=3 /ntot=3 /MaxReadThrough="0.598370000000001" /MaxDrop="4.3935" /score="-7.90227391" /energy="-11.4" /TU="NA" /idTUdmin="U174" /TUdmin="-1078" /isTUend="FALSE" /label="downshifts" CDS complement(245758..246741) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15995196, 18459799, 20050917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995196, 18459799, 20050917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutaminase" /protein_id="NP_388125.1" /db_xref="EnsemblGenomes-Gn:BSU02430" /db_xref="EnsemblGenomes-Tr:CAB12037" /db_xref="GOA:O31465" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="PDB:1MKI" /db_xref="PDB:2OSU" /db_xref="PDB:3AGF" /db_xref="PDB:3BRM" /db_xref="SubtiList:BG12753" /db_xref="UniProtKB/Swiss-Prot:O31465" /translation="MKELIKEHQKDINPALQLHDWVEYYRPFAANGQSANYIPALGKV NDSQLGICVLEPDGTMIHAGDWNVSFTMQSISKVISFIAACMSRGIPYVLDRVDVEPT GDAFNSIIRLEINKPGKPFNPMINAGALTIASILPGESAYEKLEFLYSVMETLIGKRP RIHEEVFRSEWETAHRNRALAYYLKETNFLEAEVEETLEVYLKQCAMESTTEDIALIG LILAHDGYHPIRHEQVIPKDVAKLAKALMLTCGMYNASGKYAAFVGVPAKSGVSGGIM ALVPPSARREQPFQSGCGIGIYGPAIDEYGNSLTGGMLLKHMAQEWELSIF*" /label="glsA CDS" gene complement(245758..246741) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /label="glsA gene" promotor_-10 complement(246835..246852) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 246840..246859 /Source="Nicolas_upshift_promotors" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(246842) /Source="Nicolas_upshifts" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 246846 /Source="Nicolas_upshifts" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(246868..246875) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 247043..248275 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196, 17001076, 21435182, 23461034, 25691471; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [GlnL] forglutamine degradation" /protein_id="NP_388126.2" /db_xref="EnsemblGenomes-Gn:BSU02440" /db_xref="EnsemblGenomes-Tr:CAB12038" /db_xref="GOA:P40758" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10871" /db_xref="UniProtKB/Swiss-Prot:P40758" /translation="MLITVPLAGELKFYPLNEEFRVSFGAPVFFFFLSLLRHVPAVLP GFLTGAAVFIFRVFLELWGGGHNGLTPILYDQASGFFFYMTYACLFSILKANRFRERP IMLGFIGFMIEVVSDCVELTVQFLIFHTVVTPEKITDIAVIAISHTFIVMSFYSVLKL YETQSREKQTRQQHEHMLMIVSNLYEETVHLKKTLKTTEKVTNDSYQLYREMKGKDVQ LSGRILRLAGEIHEVKKDNQRIFAGLSKLISNESLRDYMRASDLLQLVIRMNEKYAEA LGKQIDFYCSIEGEHDEYHVFIVLSIINNLTANAVEAMDEEGMVSLRLRKPNESMVEF QVEDNGPGISEKIGDIVFDPGFTSKYDEFGTPSTGIGLSYVKEIVTELEGDITFDNQQ RGVVFAIRLPVRHLIQKG*" /label="glnJ CDS" gene 247043..248275 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /label="glnJ gene" CDS 248286..249230 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [GlnJ] for glutamine utilisation" /protein_id="NP_388127.1" /db_xref="EnsemblGenomes-Gn:BSU02450" /db_xref="EnsemblGenomes-Tr:CAB12039" /db_xref="GOA:P40759" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013972" /db_xref="SubtiList:BG10872" /db_xref="UniProtKB/Swiss-Prot:P40759" /translation="MRFFIADDDRAVRSILRQIIEDEDLGEAAGEADDGSQVEGHMLQ FKQIDILLIDLLMPGRDGIETIRQIQNTYSGKIVMISQVEAKEMVGEAYSLGIEYFIH KPINRIEIVTVLQKVKERIELEHSIGAIQHSLSRLVNRTERKARPQQKSDSGLKEAGT FLLSELGMMGEGGAHDLMAVLQYLAEHEQSEPHEKQSPSLKQIFTQVAVRKLGTGASQ TEVNREMKASEQRIRRAIIHSLHHFASLGTTDFSNPKFETYASKFFDFPVVSQKMKEL QSKDAKPLAPARINMKKFIHVFFLEAKLLHETMKQRRI*" /label="glnL CDS" gene 248286..249230 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /label="glnL gene" downshifts 249207 /Source="Nicolas_upshifts" /id="D95" /incds=0 /nref=45 /ntot=191 /MaxReadThrough="1.43757" /MaxDrop="3.64091" /score="2.73020459" /energy="-6.2" /TU="NA" /idTUdmin="U177" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" promotor_-35 249327..249334 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 249339..249456 /Source="Nicolas_S_feature" /locus_tag="new_267772_267889" /HighExp="Sw, BC, M40t90, Etha, MG-0.2, HiTm, HiOs, G135, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S94" upshifts 249339 /Source="Nicolas_upshifts" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 249348..249367 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 249457..250383 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /EC_number="4.2.1.41" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5-dehydro-4-deoxyglucarate dehydratase" /protein_id="NP_388128.2" /db_xref="EnsemblGenomes-Gn:BSU02460" /db_xref="EnsemblGenomes-Tr:CAB12040" /db_xref="GOA:P42235" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017655" /db_xref="SubtiList:BG11158" /db_xref="UniProtKB/Swiss-Prot:P42235" /translation="MSRIRKAPAGILGFPVAPFNTQGKLEEEALFQNIEFLLNEGLEA IFIACGSGEFQSLSQKEYEQMVEVAVSAAGGKVPVYTGVGGNLSTALDWAQLSEKKGA DGYLILPPYLVHGEQEGLYQYAKTIIESTDLNAILYQRDNAVLSVEQIKRLTECEQLV GVKDGVGNMDLNINLVYTIGDRLGWLNGMPMAEVTMPAYLPIGFHSYSSAISNYIPHI SRMFYDALKNGNDELVKELYRHVILPINDIRKQRKGYAVSLIKAGMEIMGLNVRNTAR PPVGPVEKDHYQQLEAILKQAADRFPKKAATV*" /label="kdgD CDS" gene 249457..250383 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /label="kdgD gene" CDS 250413..251879 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /EC_number="1.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674, 17202142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,5-dioxovalerate dehydrogenase (alpha-ketoglutaric semialdehyde dehydrogenase)" /protein_id="NP_388129.1" /db_xref="EnsemblGenomes-Gn:BSU02470" /db_xref="EnsemblGenomes-Tr:CAB12041" /db_xref="GOA:P42236" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11159" /db_xref="UniProtKB/Swiss-Prot:P42236" /translation="MSVITEQNTYLNFINGEWVKSQSGDMVKVENPADVNDIVGYVQN STAEDVERAVTAANEAKTAWRKLTGAERGQYLYKTADIMEQRLEEIAACATREMGKTL PEAKGETARGIAILRYYAGEGMRKTGDVIPSTDKDALMFTTRVPLGVVGVISPWNFPV AIPIWKMAPALVYGNTVVIKPATETAVTCAKIIACFEEAGLPAGVINLVTGPGSVVGQ GLAEHDGVNAVTFTGSNQVGKIIGQAALARGAKYQLEMGGKNPVIVADDADLEAAAEA VITGAFRSTGQKCTATSRVIVQSGIYERFKEKLLQRTKDITIGDSLKEDVWMGPIASK NQLDNCLSYIEKGKQEGASLLIGGEKLENGKYQNGYYVQPAIFDNVTSEMTIAQEEIF GPVIALIKVDSIEEALNIANDVKFGLSASIFTENIGRMLSFIDEIDAGLVRINAESAG VELQAPFGGMKQSSSHSREQGEAAKDFFTAIKTVFVKP*" /label="gucD CDS" gene 250413..251879 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /label="gucD gene" CDS 251963..253330 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12044674, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucarate transporter" /protein_id="NP_388130.2" /db_xref="EnsemblGenomes-Gn:BSU02480" /db_xref="EnsemblGenomes-Tr:CAB12042" /db_xref="GOA:P42237" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11160" /db_xref="UniProtKB/Swiss-Prot:P42237" /translation="MKKDFASVTPAGKKTSVRWFIVFMLFLVTSINYADRATLSITGD SVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQ GAIGFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQY FAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEPKKHPKVNEAELAYI EQGGGLISMDDSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVY LVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFARKVPIIAGMLL SCSMIVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGN IASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLLVGPIKRVVLKKQEQDPD QSLPV*" /label="gudP CDS" gene 251963..253330 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /label="gudP gene" CDS 253367..254734 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /EC_number="4.2.1.40" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772161, 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucarate dehydratase" /protein_id="NP_388131.2" /db_xref="EnsemblGenomes-Gn:BSU02490" /db_xref="EnsemblGenomes-Tr:CAB12043" /db_xref="GOA:P42238" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR017653" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR034598" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11161" /db_xref="UniProtKB/Swiss-Prot:P42238" /translation="MSSPIQEQVQKEKRSNIPSISEMKVIPVAGHDSMLLNLSGAHSP FFTRNIVILTDSSGNQGVGEVPGGEHIRRTLELSEPLVVGKSIGAYQAILQTVRKQFG DQDRGGRGNQTFDLRTTVHAVTALEAALLDLLGKFLQEPVAALLGEGKQRDEVKMLGY LFYIGDRNRTTLPYQSDEQSDCAWFRLRHEEALTPEAIVRLAESAQERYGFQDFKLKG GVLRGEEEIEAVTALSKRFPEARITLDPNGAWSLEEAIALCKGKQDVLAYAEDPCGDE NGYSAREVMAEFRRATGLPTATNMIATDWREMGHAIQLHAVDIPLADPHFWTMQGSVR VAQMCHDWGLTWGSHSNNHFDISLAMFTHVAAAAPGRITAIDTHWIWQDGQRLTKQPF EISSGCVKVPDKPGLGVDIDMEQVEKAHEIYRKMNLGARNDAIPMQFLISNWEFDRKR PCLVR*" /label="gudD CDS" gene 253367..254734 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /label="gudD gene" promotor_-35 254748..254755 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-35" promotor_-10 254770..254787 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-10" upshifts 254773 /Source="Nicolas_upshifts" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="upshifts" CDS 254804..255505 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12044674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388132.2" /db_xref="EnsemblGenomes-Gn:BSU02500" /db_xref="EnsemblGenomes-Tr:CAB12044" /db_xref="GOA:P42239" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11162" /db_xref="UniProtKB/Swiss-Prot:P42239" /translation="MYEGLEDLKVDTVNRKTLAKQVIERIVHLLSSGQLRAGDKLPTE MELMDILHVSRPVLREALSSLETLGVITRKTRGGTYFNDKIGMQPFSVMLALATDNLP AIIEARMALELGLVTIAAEKINEEELQRLQKTIDDIANSTDNHYGEADKEFHRIIALS ANNPVVEGMIQSLLITHAKIDSQIPYRERDVTVEYHKKIYDALAKRDPYKAHYHMYEH LKFVRDKILKGMDEK*" /label="garR CDS" gene 254804..255505 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /label="garR gene" downshifts 255455 /Source="Nicolas_upshifts" /id="D96" /incds=0 /nref=1 /ntot=35 /MaxReadThrough="3.59234" /MaxDrop="2.3923" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" downshifts 255499 /Source="Nicolas_upshifts" /id="D97" /incds=0 /nref=1 /ntot=82 /MaxReadThrough="3.21794" /MaxDrop="2.49226" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS 255596..257128 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /EC_number="4.2.1.42" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772162; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-galactarate dehydratase" /protein_id="NP_388133.2" /db_xref="EnsemblGenomes-Gn:BSU02510" /db_xref="EnsemblGenomes-Tr:CAB12045" /db_xref="GOA:P42240" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR017654" /db_xref="SubtiList:BG11163" /db_xref="UniProtKB/Swiss-Prot:P42240" /translation="MAMNLRKNQAPLYIKVHEIDNTAIIVNDGGLPKGTVFSCGLVLE EDVPQGHKVALTDLNQGDEIVRYGEVIGFADETIKRGSWIREALVRMPAPPALDDLPL ANRVPQPRPPLEGYTFEGYRNADGSAGTKNILGITTSVQCVVGVLDYAVKRIKEELLP KYPNVDDVVPLHHQYGCGVAINAPDAVIPIRTIQNLAKHPNFGGEVMVIGLGCEKLLP ERIASENDDDILSLQDHRGFAAMIQSILEMAEERLIRLNSRTRVSCPVSDLVIGLQCG GSDAFSGVTANPAVGYAADLLVRAGATVLFSEVTEVRDAIHLLTPRAVSEEVGQSLIK EMKWYDSYLRRGDADRSANPSPGNKKGGLSNVVEKALGSVAKSGTSPISGVLGPGERA KQKGLLFAATPASDFVCGTLQLAAGMNLQVFTTGRGTPYGLAAAPVLKVSTRHSLSEH WADLIDINAGRIATGEASIEDVGWEIFRTILDVASGRKQTWADRWGLHNDLCLFNPAP VT*" /label="garD CDS" gene 255596..257128 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /label="garD gene" promotor_-35 257140..257143 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 257158..257177 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 257170..257404 /Source="Nicolas_S_feature" /locus_tag="new_275603_275837" /HighExp="LoTm, Sw, BC, BI, B60, B36, T3.30H, T5.0H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.50265400000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S95" upshifts 257170 /Source="Nicolas_upshifts" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 257405..258325 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_388134.1" /db_xref="EnsemblGenomes-Gn:BSU02520" /db_xref="EnsemblGenomes-Tr:CAB12046" /db_xref="GOA:P42242" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG11165" /db_xref="UniProtKB/Swiss-Prot:P42242" /translation="MTNLNEKQLITEIVGLARSQGLTVHSENAQLNETGMDFQVVFAK DDTGMPWVLRKPRRSDVVERASAEGITLAFLRANLTADVPDWRIHTPELIAYPMLKGT PAAGIDLEQKQYVWNMDHQPPSDDFVRTLADILAELHGTDQISAGQSGIEVIRPEDFR QMTADSMVDVKNKLGVSTTLWERWQKWVDDDAYWPGFSSLIHGDLHPPHILIDQNGRV TGLLDWTEAKVADPAKDFVLYQTIFGEKETARLLEYYDQAGGRIWAKMQEHISEMQAA YPVEIAKLALQTQQEEHINMALEALGVTSD*" /label="ycbJ CDS" gene 257405..258325 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /label="ycbJ gene" promotor_-35 258327..258334 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 258349..258368 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 258359 /Source="Nicolas_upshifts" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 258382..258629 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /product="T-box riboswitch specific of tryptophan tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 10706627, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 10706627, 12165569, 12547201; Product type n: RNA" /label="tboW RNA" gene 258382..258629 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /label="tboW gene" downshifts 258598 /Source="Nicolas_upshifts" /id="D98" /incds=0 /nref=225 /ntot=264 /MaxReadThrough="2.36361" /MaxDrop="6.52913" /score="36.5571172" /energy="-16.6" /TU="NA" /idTUdmin="U179" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS 258727..258888 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-TRAP regulator" /protein_id="NP_388135.1" /db_xref="EnsemblGenomes-Gn:BSU02530" /db_xref="EnsemblGenomes-Tr:CAB12047" /db_xref="GOA:O31466" /db_xref="InterPro:IPR031538" /db_xref="InterPro:IPR036410" /db_xref="PDB:2BX9" /db_xref="PDB:2KO8" /db_xref="PDB:2ZP8" /db_xref="PDB:2ZP9" /db_xref="SubtiList:BG12776" /db_xref="UniProtKB/Swiss-Prot:O31466" /translation="MVIATDDLEVACPKCERAGEIEGTPCPACSGKGVILTAQGYTLL DFIQKHLNK*" /label="rtpA CDS" gene 258727..258888 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /label="rtpA gene" promotor_no_box 258805..258905 /Source="Nicolas_upshift_promotors" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 258865 /Source="Nicolas_upshifts" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 258909..259847 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10706627, 15063849, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative tryptophan or indole exporter" /protein_id="NP_388136.1" /db_xref="EnsemblGenomes-Gn:BSU02540" /db_xref="EnsemblGenomes-Tr:CAB12048" /db_xref="GOA:P42243" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG11166" /db_xref="UniProtKB/Swiss-Prot:P42243" /translation="MRAEEQSKIREAAAGTIFLLIGTVCFASKSIWIKWAYQMGAEPD AVLLYRQLLAVPLFWLIFLIYRPPMPDGKKKGDLWKACGAGVFCFFLSPLLDFIGLNH VSAMVERILLMSYPLFVFGFTACRDRKMSSIQDLFAVLAVMFGLFLALGGWNAELFQA NMIGAVFILLSSAVYAGYLVLSGHLVHQIGGIRLNAYGMTAAGAAMMLYTGIKSAAGM NTPMAAYPLSMYGLFAVIAVVTTVIPFVLMLEGIKRIGAQRAAAISMAGPILTIFYGA LFLGERLGLIQVIGCGGVFFVITGMEYRKLKTGKKE*" /label="ycbK CDS" gene 258909..259847 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /label="ycbK gene" downshifts 258953 /Source="Nicolas_upshifts" /id="D99" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="3.05417" /MaxDrop="3.72787" /score="0.773303272" /energy="-9" /TU="NA" /idTUdmin="U181" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 259870..259889 /Source="Nicolas_upshift_promotors" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 259875..259943 /Source="Nicolas_S_feature" /locus_tag="new_278308_278376" /HighExp="C90, dia5, Lbtran, Lbexp, LBGexp, SMM, dia0, dia15, BMM, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S96" upshifts 259875 /Source="Nicolas_upshifts" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="upshifts" CDS 259944..260624 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YcbM]" /protein_id="NP_388137.2" /db_xref="EnsemblGenomes-Gn:BSU02550" /db_xref="EnsemblGenomes-Tr:CAB12049" /db_xref="GOA:P42244" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11167" /db_xref="UniProtKB/Swiss-Prot:P42244" /translation="MLVEDDHSISEMVDHYLTKEGFGIVHAFDGEEGIRLFQQGSYDL VLLDIMLPKLNGMDFLKIIREKSNIPVLMISAKDGDVDKALGLGFGADDYIAKPFSMI ELTARVKAAIRRATQYSAEEPAVNKVIRIHQLAIDIDNVSVLKNGEPLQLTSTEWQLL CLFASNPKKVFTKEQIYRSVWNEEYFDDQNIINVHMRRLREKIEDDPSSPQYIKTLWG IGYKLGEF*" /label="ycbL CDS" gene 259944..260624 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /label="ycbL gene" CDS 260626..261561 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YcbL]" /protein_id="NP_388138.2" /db_xref="EnsemblGenomes-Gn:BSU02560" /db_xref="EnsemblGenomes-Tr:CAB12050" /db_xref="GOA:P42245" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11168" /db_xref="UniProtKB/Swiss-Prot:P42245" /translation="MTVLWVAAVIALACLNVIQFIMKKKRDGNLAYTADQLSYMLSRD SAGQILLPTDDHALKDLLVNINLIVENRQQISAQFAKTEQSMKRMLTNMSHDLKTPLT VILGYIEAIQSDPNMPDEERERLLGKLRQKTNELIQMINSFFDLAKLESEDKEIPITK VHMNDICKRNILHYYDAVQSKGFQAAIDIPDTPVYAQANEEALDRILQNLLSNAIQYG AAGKLIGLTLSYDERNIAITVWDRGKGISETDQQRVFERLYTLEESRNKAFQGSGLGL TITKRLTEKMGGIISVQSKPYERTAFTITLKRMTY*" /label="ycbM CDS" gene 260626..261561 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /label="ycbM gene" CDS 261653..262576 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388139.2" /db_xref="EnsemblGenomes-Gn:BSU02570" /db_xref="EnsemblGenomes-Tr:CAB12051" /db_xref="GOA:P42246" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11169" /db_xref="UniProtKB/Swiss-Prot:P42246" /translation="MTYIVQTNGLTKTYQGKEVVSNVSMHIKKGEIYGFLGPNGAGKT TIMKMLTSLVKPTSGEIIILGNKFTHTSYEVLGNIGSMIEYPIFYENLTAEENLDLHC EYMGYHNKKAIQEVLDMVNLKQIDKKPVKTFSLGMKQRLGIARAILTKPDLLILDEPV NGLDPLGIKKIRQLFQVLSKEYGMTLLISSHLLGEIEQIADTIGVIRDGRLLEEVSME DVRGQNTEYIELVTPNQTRACFVLEKELQLTNFKILNEKTIRIYEAEASQAAISKALI LNDVDIESMNKKYTSLEDYFIKLINGNSISA*" /label="ycbN CDS" gene 261653..262576 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /label="ycbN gene" S_feature complement(262123..263307) /Source="Nicolas_S_feature" /locus_tag="new_280556_281740_c" /HighExp="Etha, Sw, Gly, B36, LoTm, B60, GM 150, Salt, C30, ferm" /AntisenseName="ycbO" /AntisenseCor="-0.38911425676406203" /AntisenseRegPval="-10.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S97" CDS 262595..263281 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven exporter" /protein_id="NP_388140.3" /db_xref="EnsemblGenomes-Gn:BSU02580" /db_xref="EnsemblGenomes-Tr:CAB12052" /db_xref="GOA:P42247" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11170" /db_xref="UniProtKB/Swiss-Prot:P42247" /translation="MNLIRIELRKMKMGWYIRGALIANVIIMGFMWLISYSEKADGGV SFQSTDEAFLIIGTFVRAVFIVFGAVLIVKLVISEYKNKTILVMFTYPISRKKLLTAK LMIAGGLTFITILLSNILIAAGFFWLNSICHFIPGELTSEIISQQAVKMAVFAFGAAG TSLVPIFFGMRRHSVPATIISSVVIVMLISSTSPGFSISSVVYIPLSLAAFGLFFSYM AIRNADKQDA*" /label="ycbO CDS" gene 262595..263281 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /label="ycbO gene" CDS complement(263242..263376) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513940.1" /translation="MARSIILKQEQTHNGKAGADSIGLLYILGAFVYASCLSAFLIAM *" /label="hypothetical protein CDS" gene complement(263242..263376) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /label="gene" downshifts 263276 /Source="Nicolas_upshifts" /id="D100" /incds=0 /nref=8 /ntot=120 /MaxReadThrough="1.13131" /MaxDrop="3.44039" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" CDS complement(263336..263722) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22582280; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative inner integral membrane protein" /protein_id="NP_388141.1" /db_xref="EnsemblGenomes-Gn:BSU02590" /db_xref="EnsemblGenomes-Tr:CAB12053" /db_xref="GOA:P42248" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG11171" /db_xref="UniProtKB/Swiss-Prot:P42248" /translation="MTHVKALAIKGIMTIIVLYLVLGLGFGFTFGDTLLMTIVLGVIS YLLGDLYVLPKWNNMIATLADFGLAFLVIWLMGMPLSMGMTGGEVALAALFGAIVMAI GEYCFHFYMMSKEIGKKHYLETRTDS*" /label="ycbP CDS" gene complement(263336..263722) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /label="ycbP gene" downshifts complement(263352) /Source="Nicolas_upshifts" /id="D101" /incds=0 /nref=148 /ntot=217 /MaxReadThrough="6.64196" /MaxDrop="7.40353" /score="13.8182557" /energy="-15.6" /TU="U183" /idTUdmin="U185" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(263748..263766) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(263767) /Source="Nicolas_upshifts" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(263780..263786) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(263800..264798) /Source="Nicolas_S_feature" /locus_tag="new_282233_283231_c" /HighExp="GM 150, T0.30H, C30, T1.30H, T1.0H, T-0.40H, T-3.40H, T2.0H, T2.30H, T-4.40H" /AntisenseName="cwlJ" /AntisenseCor="0.11463160303596701" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S98" downshifts complement(263843) /Source="Nicolas_upshifts" /id="D102" /incds=0 /nref=3 /ntot=10 /MaxReadThrough="5.23914" /MaxDrop="3.14515" /score="13.8182557" /energy="-15.6" /TU="U185,U187" /idTUdmin="U185" /TUdmin="-491" /isTUend="FALSE" /label="downshifts" promotor_-35 263979..263984 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 263998 /Source="Nicolas_upshifts" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 264000..264018 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264012) /Source="Nicolas_upshifts" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(264014..264028) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(264034) /Source="Nicolas_upshifts" /id="D103" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="5.64474" /MaxDrop="3.76775" /score="13.8182557" /energy="-15.6" /TU="U187" /idTUdmin="U185" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 complement(264036..264040) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 264036..264464 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore cortex cell wall hydrolase" /protein_id="NP_388142.2" /db_xref="EnsemblGenomes-Gn:BSU02600" /db_xref="EnsemblGenomes-Tr:CAB12054" /db_xref="GOA:P42249" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG11172" /db_xref="UniProtKB/Swiss-Prot:P42249" /translation="MAVVRATSADVDLMARLLRAEAEGEGKQGMLLVGNVGINRLRAN CSDFKGLRTIRQMIYQPHAFEAVTHGYFYQRARDSERALARRSINGERRWPAKFSLWY FRPQGDCPAQWYNQPFVARFKSHCFYQPTAETCENVYNTF*" /label="cwlJ CDS" gene 264036..264464 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /label="cwlJ gene" downshifts 264443 /Source="Nicolas_upshifts" /id="D104" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.30044" /MaxDrop="5.89045" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 264509..264515 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 264528..264547 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 264530 /Source="Nicolas_upshifts" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="upshifts" CDS 264570..265301 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388143.2" /db_xref="EnsemblGenomes-Gn:BSU02610" /db_xref="EnsemblGenomes-Tr:CAB12055" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR019303" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG11173" /db_xref="UniProtKB/Swiss-Prot:P42250" /translation="MATIDLQKKSVKIVLEKKQLTKVTARVGLVLDITGSMRPLYKNG TVQNVVERILAVADQFDDNGLLDVWVYDNEFSRLKPVSEKDFSGYVDREILNNDRLHK FGRNDEPPVMKDVLRKYVTEEPSSYPAFIVFINDGGCKKSIKPIIEASSDKPVFWQFV GIGNGNFDFLNKLDTLEGRVIDNTNFLHIEEIDRISDDELYDALLAEFPFWLKEAKEK GIVREQEPPAEKPKKKGFFSRLFSK*" /label="ycbR CDS" gene 264570..265301 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /label="ycbR gene" promotor_-10 complement(264772..264791) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264798) /Source="Nicolas_upshifts" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(264805..264812) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 265219 /Source="Nicolas_upshifts" /id="D105" /incds=1 /nref=9 /ntot=148 /MaxReadThrough="1.70712" /MaxDrop="3.61288" /score="25.6672471" /energy="-14.1" /TU="NA" /idTUdmin="U186" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 265383..265559 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097673.1" /db_xref="EnsemblGenomes-Gn:BSU02619" /db_xref="EnsemblGenomes-Tr:CAX52543" /db_xref="UniProtKB/Swiss-Prot:C0H3T2" /translation="MGGLQTTGYAENASFSQLSACFSSRLVREDLFLMFSAYNQFTLL HSRLTMISYNGDDQ*" /label="yczK CDS" gene 265383..265559 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /label="yczK gene" promotor_-35 265511..265517 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 265524..265541 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 265535 /Source="Nicolas_upshifts" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="upshifts" CDS 265578..267329 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted phosphodiesterase (endo-hydrolysis at non-specific sites throughout the cell wall teichoic acid polymer)" /protein_id="NP_388144.2" /db_xref="EnsemblGenomes-Gn:BSU02620" /db_xref="EnsemblGenomes-Tr:CAB12056" /db_xref="GOA:P42251" /db_xref="InterPro:IPR008963" /db_xref="InterPro:IPR018946" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR032093" /db_xref="PDB:2YEQ" /db_xref="SubtiList:BG11174" /db_xref="UniProtKB/Swiss-Prot:P42251" /translation="MAYDSRFDEWVQKLKEESFQNNTFDRRKFIQGAGKIAGLSLGLT IAQSVGAFEVNAAPNFSSYPFTLGVASGDPLSDSVVLWTRLAPDPLNGGGMPKQAVPV KWEVAKDEHFRKIVRKGTEMAKPSLAHSVHVEADGLEPNKVYYYRFKTGHELSPVGKT KTLPAPGANVPQMTFAFASCQQYEHGYYTAYKHMAKEKLDLVFHLGDYIYEYGPNEYV SKTGNVRTHNSAEIITLQDYRNRHAQYRSDANLKAAHAAFPWVVTWDDHEVENNYANK IPEKGQSVEAFVLRRAAAYQAYYEHMPLRISSLPNGPDMQLYRHFTYGNLASFNVLDT RQYRDDQANNDGNKPPSDESRNPNRTLLGKEQEQWLFNNLGSSTAHWNVLAQQIFFAK WNFGTSASPIYSMDSWDGYPAQRERVINFIKSKNLNNVVVLTGDVHASWASNLHVDFE KTSSKIFGAEFVGTSITSGGNGADKRADTDQILKENPHIQFFNDYRGYVRCTVTPHQW KADYRVMPFVTEPGAAISTRASFVYQKDQTGLRKVSSTTIQGGVKQSDEVEEDRFFSH NKAHEKQMIKKRAKITN*" /label="phoD CDS" gene 265578..267329 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /label="phoD gene" promotor_-10 complement(265632..265647) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(265638) /Source="Nicolas_upshifts" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(265660..265669) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 267342..267554 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867413, 15554971, 16678787, 19049517, 21479530, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867413, 15554971, 16678787, 19049517, 21479530, 27984091; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388145.2" /db_xref="EnsemblGenomes-Gn:BSU02630" /db_xref="EnsemblGenomes-Tr:CAB12057" /db_xref="GOA:O31467" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR003998" /db_xref="InterPro:IPR006312" /db_xref="PDB:2L16" /db_xref="SubtiList:BG12777" /db_xref="UniProtKB/Swiss-Prot:O31467" /translation="MFSNIGIPGLILIFVIALIIFGPSKLPEIGRAAGRTLLEFKSAT KSLVSGDEKEEKSAELTAVKQDKNAG*" /label="tatAD CDS" gene 267342..267554 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /label="tatAD gene" S_feature 267555..267614 /Source="Nicolas_S_feature" /locus_tag="new_285988_286047" /HighExp="LPhT, BI, Paraq, C90, H2O2, M40t90, C30, M0t90, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0569" /TUlongSig="NA" /TUlongPSig="NA" /label="S99" CDS 267615..268343 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16698798, 19049517, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16698798, 19049517, 27984091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388146.2" /db_xref="EnsemblGenomes-Gn:BSU02640" /db_xref="EnsemblGenomes-Tr:CAB12058" /db_xref="GOA:P42252" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG11175" /db_xref="UniProtKB/Swiss-Prot:P42252" /translation="MDKKETHLIGHLEELRRRIIVTLAAFFLFLITAFLFVQDIYDWL IRDLDGKLAVLGPSEILWVYMMLSGICAIAASIPVAAYQLWRFVAPALTKTERKVTLM YIPGLFALFLAGISFGYFVLFPIVLSFLTHLSSGHFETMFTADRYFRFMVNLSLPFGF LFEMPLVVMFLTRLGILNPYRLAKARKLSYFLLIVVSILITPPDFISDFLVMIPLLVL FEVSVTLSAFVYKKRMREETAAAA*" /label="tatCD CDS" gene 267615..268343 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /label="tatCD gene" downshifts complement(267623) /Source="Nicolas_upshifts" /id="D106" /incds=0 /nref=4 /ntot=146 /MaxReadThrough="1.2763" /MaxDrop="3.13944" /score="-9.00478071" /energy="-8.5" /TU="NA" /idTUdmin="U190" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(268340..268987) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /EC_number="3.4.19.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1362573, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1362573, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrrolidone-carboxylate (pyroglutamate) peptidase" /protein_id="NP_388147.1" /db_xref="EnsemblGenomes-Gn:BSU02650" /db_xref="EnsemblGenomes-Tr:CAB12059" /db_xref="GOA:P28618" /db_xref="InterPro:IPR000816" /db_xref="InterPro:IPR016125" /db_xref="InterPro:IPR029762" /db_xref="InterPro:IPR033693" /db_xref="InterPro:IPR033694" /db_xref="InterPro:IPR036440" /db_xref="SubtiList:BG10873" /db_xref="UniProtKB/Swiss-Prot:P28618" /translation="MRKKVLITGFDPFDKETVNPSWEAAKRLNGFETEEAIITAEQIP TVFRSALDTLRQAIQKHQPDIVICVGQAGGRMQITPERVAINLADARIPDNEGHQPID EEISPDGPAAYWTRLPVKRMTAKMKEHGIPAAVSYTAGTFVCNYLFYGLMDHISRTSP HIRGGFIHIPYIPQQTIDKTAPSLSLDTIVRALRIAAVTAAQYDEDVKSPGGTLH*" /label="pcp CDS" gene complement(268340..268987) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /label="pcp gene" promotor_-10 complement(269002..269021) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 269015..269021 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(269016) /Source="Nicolas_upshifts" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(269036..269040) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 269036..269055 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 269038 /Source="Nicolas_upshifts" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="upshifts" CDS 269066..270178 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase (PLP-dependent)" /protein_id="NP_388148.2" /db_xref="EnsemblGenomes-Gn:BSU02660" /db_xref="EnsemblGenomes-Tr:CAB12060" /db_xref="GOA:P42253" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG11176" /db_xref="UniProtKB/Swiss-Prot:P42253" /translation="MEHLPEQYRQLFPTLQTHTMLASCSQSALAEPVSRAIQDYYDSL LYKGTNWKEAIEKTEFARNEFAKLIGAEPDEVAIVPSVSDALVSVASSLTAFGKKHVV YTDMDFPAVPHVWQAHSDYTVSVIPSIDGVLPLEQYETHISDETVLTCVPHVHYRDGY VQDIKAIAEISQRKGSLLFVDAYQSAGHIPIDVKEWGVDMLAAGTRKYLLGIPGVAFL YVRKELADALKPKASAWFGRESGFDGAYAKVARRFQTGTPAFISVYAAAAALSLLNHI GVSHIRDHVKTICADAVQYAAEKGLQLAAAQGGIQPGMVAIRDERASETAGLLKKKKV ICAPRENVIRLAPHFYNTKEEMRHAIDEIAAKTIHK*" /label="ycbU CDS" gene 269066..270178 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /label="ycbU gene" upshifts complement(269412) /Source="Nicolas_upshifts" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(269415..269434) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(269450..269454) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 270172 /Source="Nicolas_upshifts" /id="D107" /incds=0 /nref=45 /ntot=226 /MaxReadThrough="1.10091" /MaxDrop="4.52742" /score="6.75687898" /energy="-14" /TU="NA" /idTUdmin="U191" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(270220..271659) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 17483215; Product type t: transporter" /codon_start=1 /transl_table=11 /product="flavonoid efflux transporter; drug-export protein" /protein_id="NP_388149.1" /db_xref="EnsemblGenomes-Gn:BSU02670" /db_xref="EnsemblGenomes-Tr:CAB12061" /db_xref="GOA:O35018" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12613" /db_xref="UniProtKB/Swiss-Prot:O35018" /translation="MILETTAKASQQYKVMPIMISLLLAGFIGMFSETALNIALTDLM KELNITAATVQWLTTGYLLVLGILVPVSGLLLQWFTTRQLFTVSLIFSILGTFIAALA PSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTF SGLVLEHLNWHWIFWISLPFLVLALVFGIAYMQNVSETTKPKIDVLSIILSTIGFGGI VFGFSNAGEGSGGWSSPTVIVSLIVGVVGLILFSIRQLTMKQPMMNLRAFKYPMFILG VIMVFICMMVILSSMLLLPMYLQGGLVLTAFASGLVLLPGGILNGFMSPVTGRLFDKY GPKWLVIPGFVIVTVVLWFFSNVTTTSTAVLIIILHTCLMIGISMIMMPAQTNGLNQL PREFYPDGTAIMNTLQQMAGAIGTAVAVSIMAAGQHDYMSTVKNPADPAVIPQALTAG VQHAFVFAMIVAIIGLIGAFFMKRVKVDH*" /label="lmrB CDS" gene complement(270220..271659) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /label="lmrB gene" downshifts complement(270227) /Source="Nicolas_upshifts" /id="D108" /incds=0 /nref=162 /ntot=245 /MaxReadThrough="0.65833" /MaxDrop="6.75228" /score="18.3484535" /energy="-14" /TU="U193" /idTUdmin="U193" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(271699..272265) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12718394, 15317768, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12718394, 15317768, 17483215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of lmrAB and yxaGH operons (flavonoid and antibiotic resistance)" /protein_id="NP_388150.1" /db_xref="EnsemblGenomes-Gn:BSU02680" /db_xref="EnsemblGenomes-Tr:CAB12062" /db_xref="GOA:O34619" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12612" /db_xref="UniProtKB/Swiss-Prot:O34619" /translation="MSYGDSREKILSAATRLFQLQGYYGTGLNQIIKESGAPKGSLYY HFPGGKEQLAIEAVNEMKEYIRQKIADCMEACTDPAEGIQAFLKELSCQFSCTEDIEG LPVGLLAAETSLKSEPLREACHEAYKEWASVYEEKLRQTGCSESRAKEASTVVNAMIE GGILLSLTAKNSTPLLHISSCIPDLLKR*" /label="lmrA CDS" gene complement(271699..272265) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /label="lmrA gene" promotor_-10 complement(272303..272322) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(272317) /Source="Nicolas_upshifts" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(272337..272344) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 272419..272425 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 272441..272458 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 272447 /Source="Nicolas_upshifts" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="upshifts" CDS 272482..273609 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /EC_number="3.5.1.1" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914346, 17686772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346, 17686772; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-asparaginase 2 (putative lipoprotein)" /protein_id="NP_388151.1" /db_xref="EnsemblGenomes-Gn:BSU02690" /db_xref="EnsemblGenomes-Tr:CAB12063" /db_xref="GOA:O34482" /db_xref="InterPro:IPR004550" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG12755" /db_xref="UniProtKB/Swiss-Prot:O34482" /translation="MKKQRMLVLFTALLFVFTGCSHSPETKESPKEKAQTQKVSSASA SEKKDLPNIRILATGGTIAGADQSKTSTTEYKAGVVGVESLIEAVPEMKDIANVSGEQ IVNVGSTNIDNKILLKLAKRINHLLASDDVDGIVVTHGTDTLEETAYFLNLTVKSDKP VVIVGSMRPSTAISADGPSNLYNAVKVAGAPEAKGKGTLVVLNDRIASARYVTKTNTT TTDTFKSEEMGFVGTIADDIYFNNEITRKHTKDTDFSVSNLDELPQVDIIYGYQNDGS YLFDAAVKAGAKGIVFAGSGNGSLSDAAEKGADSAVKKGVTVVRSTRTGNGVVTPNQD YAEKDLLASNSLNPQKARMLLMLALTKTNDPQKIQAYFNEY*" /label="ansZ CDS" gene 272482..273609 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /label="ansZ gene" downshifts 273582 /Source="Nicolas_upshifts" /id="D109" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="1.70459" /MaxDrop="4.27333" /score="23.2201078" /energy="-7.6" /TU="NA" /idTUdmin="U194" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 273706..273712 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 273726..273745 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 273726 /Source="Nicolas_upshifts" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 273772..274410 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8396026, 15812018, 18053819, 11029590, 24827611, 28963005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8396026, 15812018, 18053819, 11029590, 24827611, 28963005; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="secreted alkaliphilic lipase" /protein_id="NP_388152.1" /db_xref="EnsemblGenomes-Gn:BSU02700" /db_xref="EnsemblGenomes-Tr:CAB12064" /db_xref="GOA:P37957" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="PDB:1I6W" /db_xref="PDB:1ISP" /db_xref="PDB:1R4Z" /db_xref="PDB:1R50" /db_xref="PDB:1T2N" /db_xref="PDB:1T4M" /db_xref="PDB:2QXT" /db_xref="PDB:2QXU" /db_xref="PDB:3D2A" /db_xref="PDB:3D2B" /db_xref="PDB:3D2C" /db_xref="PDB:3QMM" /db_xref="PDB:3QZU" /db_xref="PDB:5CRI" /db_xref="PDB:5CT4" /db_xref="PDB:5CT5" /db_xref="PDB:5CT6" /db_xref="PDB:5CT8" /db_xref="PDB:5CT9" /db_xref="PDB:5CTA" /db_xref="PDB:5CUR" /db_xref="SubtiList:BG10679" /db_xref="UniProtKB/Swiss-Prot:P37957" /translation="MKFVKRRIIALVTILMLSVTSLFALQPSAKAAEHNPVVMVHGIG GASFNFAGIKSYLVSQGWSRDKLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGAKKV DIVAHSMGGANTLYYIKNLDGGNKVANVVTLGGANRLTTGKALPGTDPNQKILYTSIY SSADMIVMNYLSRLDGARNVQIHGVGHIGLLYSSQVNSLIKEGLNGGGQNTN*" /label="estA CDS" gene 273772..274410 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /label="estA gene" downshifts 274396 /Source="Nicolas_upshifts" /id="D110" /incds=0 /nref=15 /ntot=117 /MaxReadThrough="4.54554" /MaxDrop="4.10395" /score="23.2201078" /energy="-7.6" /TU="U195" /idTUdmin="U194" /TUdmin=814 /isTUend="FALSE" /label="downshifts" S_feature 274441..275031 /Source="Nicolas_S_feature" /locus_tag="new_292874_293464" /HighExp="M9-tran, GM 150, LoTm, MG 150, GM 120, aero, T-1.40H, M/G, S2, GM 90" /AntisenseName="yczC" /AntisenseCor="3.5651747957185502E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S100" CDS complement(274448..274831) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_388153.1" /db_xref="EnsemblGenomes-Gn:BSU02710" /db_xref="EnsemblGenomes-Tr:CAB12065" /db_xref="GOA:O31469" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG12778" /db_xref="UniProtKB/Swiss-Prot:O31469" /translation="MELAGFMLRACALLLDVIIAAAVILAAGFTFGDGSAGVIIVAIL MLIVYPLLMPLTNWKGTLGKKIIGLQIVRDETYKKISFPQAIVRYLIAWVHVFSRLIY LTAAFTKKKQTVHDMAAKTIVLKAE*" /label="yczC CDS" gene complement(274448..274831) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /label="yczC gene" downshifts complement(274472) /Source="Nicolas_upshifts" /id="D111" /incds=0 /nref=4 /ntot=94 /MaxReadThrough="0.85389" /MaxDrop="2.7858" /score="15.0330092" /energy="-12.1" /TU="NA" /idTUdmin="U196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" Polymorphism join(274645,274647) /Source="geneious" /ID="SNP_BsDelta6_293079_293079" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=186 /Change="C -> T" /Codon_Change="CTG -> CTA" /Coverage=154 /locus_tag="BSU_02710" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" promotor_-10 complement(274861..274880) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(274868) /Source="Nicolas_upshifts" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(274894..274901) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 275003..275006 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 275022..275041 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 275033 /Source="Nicolas_upshifts" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 275066..276142 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388154.1" /db_xref="EnsemblGenomes-Gn:BSU02720" /db_xref="EnsemblGenomes-Tr:CAB12066" /db_xref="GOA:O34478" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR007889" /db_xref="InterPro:IPR036915" /db_xref="SubtiList:BG12756" /db_xref="UniProtKB/Swiss-Prot:O34478" /translation="MGKVKRNAPCPCGSGKKYKKCCGSKVVDFPAELAAKEAKQIQED LVEYAFTVHRESISGFINQHDFLSAMDRQTKDISVFNLGIWGIFFHPLAGEKTIFEEY LQKKGDSITRPKTREIVESWQSMTPALLLLKDLKEGIIHFEDVITAKQFEVEMDASNQ DLPPVGSLILGYPIHEAEKAEFFMQFTIFPVKRTEALISKVKKYADAAVKDGKTPEDF MKQEFNNVLFALLAEKDEEPQAEKAEVSTVEWANDLEKETAAAIEEGMSGEEYPTELI PAVIDIWKTFCEKKSPVIRKPEAFAAAVEYYVNAISLNGASVSQAKLAKKYGVSASTI SSRYKEIESTLQDEADRFAQALSS*" /label="yccF CDS" gene 275066..276142 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /label="yccF gene" downshifts 276136 /Source="Nicolas_upshifts" /id="D112" /incds=0 /nref=60 /ntot=248 /MaxReadThrough="1.55048" /MaxDrop="5.18328" /score="33.0000484" /energy="-12.9" /TU="NA" /idTUdmin="U197" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(276182..277138) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [NatR]" /protein_id="NP_388155.1" /db_xref="EnsemblGenomes-Gn:BSU02730" /db_xref="EnsemblGenomes-Tr:CAB12067" /db_xref="GOA:P70954" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR032834" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11997" /db_xref="UniProtKB/Swiss-Prot:P70954" /translation="MITLFQCLYLILFSFICYQGAAAFSHSTAASWLAAALGAAAAGL YIWNTKRVWKHCSSGLCAWIAVIQVMSVGVVLIGTDIMPVLCVIAIFAGCEGLRIGQS ALQARLSDQIDKLTQAEQHANQMLIDVRSRNHDTMKHITAIKSAQPKADTQAYIQNWA DQYSQYDRFLKGENAYVAGVLYDFLEKARASNVSVSLHMHTPLSSLPFSPADQVSLVG NILENALDSAAEAREKAEIKLETSLRSGLYVLTCENSTPGMDPKVLDTIYQSFGRSTK NGAHEGMGTYIIQKLVKGAFGRLDFTYRHPIFRLEIKIPFQK*" /label="natK CDS" gene complement(276182..277138) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /label="natK gene" downshifts complement(276210) /Source="Nicolas_upshifts" /id="D113" /incds=0 /nref=1 /ntot=129 /MaxReadThrough="0.86926" /MaxDrop="2.67125" /score="14.02819" /energy="-12.9" /TU="NA" /idTUdmin="U198" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(277151..277852) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [NatK]" /protein_id="NP_388156.1" /db_xref="EnsemblGenomes-Gn:BSU02740" /db_xref="EnsemblGenomes-Tr:CAB12068" /db_xref="GOA:P70955" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11998" /db_xref="UniProtKB/Swiss-Prot:P70955" /translation="MVKVGLVDDYRVDLEKLEAIVSRMQDVEIVFSTDSAKEAYRRVK NGDIDLLLADIEMPHMSGYELADLIKSHSLDVDVIFVTGHGGYAVHAFDLNVHDYIMK PYYADRLAASFDRYLKKKTETSLNGRILIKQKSEMHVLQKKDIIFAERTGRSTTIVTT AEEVQTYQTLNDIKGDLPEKDFLRSHRSFIINIHYIKHFSAYTKHSFTVSFEGTSKKA MITKQQLDYFQNYYF*" /label="natR CDS" gene complement(277151..277852) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /label="natR gene" promotor_-10 complement(277876..277895) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(277882) /Source="Nicolas_upshifts" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(277911..277914) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 277932..277935 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 277951..277970 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 277961 /Source="Nicolas_upshifts" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 277996..278736 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10356997, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388157.1" /db_xref="EnsemblGenomes-Gn:BSU02750" /db_xref="EnsemblGenomes-Tr:CAB12069" /db_xref="GOA:P46903" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11338" /db_xref="UniProtKB/Swiss-Prot:P46903" /translation="MITLTDCSRRFQDKKKVVKAVRDVSLTIEKGEVVGILGENGAGK TTMLRMIASLLEPSQGVITVDGFDTVKQPAEVKQRIGVLFGGETGLYDRMTAKENLQY FGRLYGLNRHEIKARIEDLSKRFGMRDYMNRRVGGFSKGMRQKVAIARALIHDPDIIL FDEPTTGLDITSSNIFREFIQQLKREQKTILFSSHIMEEVQALCDSVIMIHSGEVIYR GALESLYESERSEDLNYIFMSKLVRGIS*" /label="natA CDS" gene 277996..278736 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /label="natA gene" CDS 278737..279897 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10356997, 15849754, 16850406, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 15849754, 16850406, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (permease)" /protein_id="NP_388158.1" /db_xref="EnsemblGenomes-Gn:BSU02760" /db_xref="EnsemblGenomes-Tr:CAB12070" /db_xref="GOA:P46904" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11339" /db_xref="UniProtKB/Swiss-Prot:P46904" /translation="MLSHIYKKEMIDALRDRKTILLTILVPMIMMLGLVFFYESMLSD KGEQYTLAVGHSLPPALESKLNEIDEISVKTFAKPEEAVDEGKADAYLNVPKEFDSYV NSMTPFKVDVYGNSIDQGSSNAMQLVQSALDQYKNEIVQQRLTNKHIDQSVIQPFTIQ QKEADEEKGTSAIMLSAILPMLILTSIVSGAMPIALDIMAGEKDRKSIEALLLTPVSR NKVLVGKWLAVSTFGVASGVFALVFLILSTVLFTENLKTAFQLGDHMWSVIGASALII VLSALLISAMELFISIMSSSVKEAQSYMSLVVFLPVFPMFFIFSKAPNQFDLSYFLIP FLNLHALFKQLLFGMVDPATILSTSGTIAVLIAIFFLLARACFLKDKWVLPK*" /label="natB CDS" gene 278737..279897 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /label="natB gene" promotor_-35 279948..279956 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 279968..279986 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 279968 /Source="Nicolas_upshifts" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 280033..280965 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /EC_number="1.-.-.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322186, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ion channel associated aldo-keto reductase" /protein_id="NP_388159.1" /db_xref="EnsemblGenomes-Gn:BSU02770" /db_xref="EnsemblGenomes-Tr:CAB12071" /db_xref="GOA:P46905" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11340" /db_xref="UniProtKB/Swiss-Prot:P46905" /translation="MDQTRTLGKTKLKVKRIGFGANAVGGHNLFPNLNDETGKDLVRT ALDGGVNFIDTAFIYGLGRSEELIGEVVQERGVRNELIIATKGAHKEVDGSIELDNSR EFLRSEVEKSLKRLKTDYIDLYYVHFPDGKTPLAEVAGTLKELKDEGKIKAIGASNLD YQQLQDFNADGYLEVFQAEYSLIQRDAEKELLPYCEKQGISFIPYFPLASGLLTGKFT QDTVFDDFRKDKPQFQGETFIHNLKKVDKLKAVAEEKQADTAHVALAWLLTRPAIDAI IPGAKRPEQLQDNLKTLNIELTEDEVNFISDIFK*" /label="yccK CDS" gene 280033..280965 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /label="yccK gene" CDS complement(281005..282069) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 22496484; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in swarming behaviour" /protein_id="NP_388160.1" /db_xref="EnsemblGenomes-Gn:BSU02780" /db_xref="EnsemblGenomes-Tr:CAB12072" /db_xref="GOA:O34538" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="InterPro:IPR031343" /db_xref="PDB:4R4G" /db_xref="SubtiList:BG12757" /db_xref="UniProtKB/Swiss-Prot:O34538" /translation="MFQKKTYAVFLILLLMMFTAACSGSKTSAEKKESETEKSSDIAQ VKIKDVSYTLPSKYDKSTSDDQLVLKVNVAVKNTGKDPLNVDSMDFTLYQGDTKMSDT DPEDYSEKLQGSTINADKSVEGNLFFVVDKGKQYELNYTPESYGDKKPKSVTFKIDGK DKKILATADKLQDSAKALSAYVDVLLFGKDNADFEKITGANKNEIVNDFNESAKDGYL SASGLSSTYADSKALDNIVNGIKEGLSKNSSIQAKTTSISKDEAIVEATVKPVDASSL SDRIEDKVKDYYSKNSSASYEEAVKYALQVYPEEFKKLGPASSEKTVEVKMKKNDIDQ WQLDMDDYRAAELVEAFIKE*" /label="ycdA CDS" gene complement(281005..282069) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /label="ycdA gene" downshifts complement(281006) /Source="Nicolas_upshifts" /id="D114" /incds=0 /nref=198 /ntot=222 /MaxReadThrough="0.57029" /MaxDrop="8.85093" /score="27.0612397" /energy="-13.7" /TU="NA" /idTUdmin="U201" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(282070..282260) /Source="Nicolas_S_feature" /locus_tag="new_300503_300693_c" /HighExp="S5, S4, MG 45, MG 15, MG-0.2, MG 25, MG-0.1, MG 10, S3, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S101" CDS complement(282092..282223) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513941.1" /translation="MTKEGGVSRKSGENREKRTDFFGYMMLIHSKRSISQRQKTPLS* " /label="hypothetical protein CDS" gene complement(282092..282223) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /label="gene" promotor_-10 complement(282245..282264) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(282265) /Source="Nicolas_upshifts" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(282279..282286) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 282397..283815 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388161.1" /db_xref="EnsemblGenomes-Gn:BSU02790" /db_xref="EnsemblGenomes-Tr:CAB12073" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12758" /db_xref="UniProtKB/Swiss-Prot:O34621" /translation="MKGAAFVKKEGLKQKALEIGRVPTHLKLEIEDYGGDDKRAHFCW ADPQDENTGIIVELGPDGELESLSRDIEPESGERLSEEKLEDIMRQFVETHHPGALSA FVREENDRAYGDKVRFSYVQMEAGLPLPMSGFMADVSLSGEIVYFRYYGEAGSIIKPK RVADVEEALAFIKKDVEFDLLFEVLHRSVYKNGDDQPHLVYEPEGRAITVPADLVQEE QAVDDDDDYREPESFPLPLFEGIREKADPDSMIGIENGFVKEREADLGDGRIGIVWRN PDDPVYQPADKSMDSWFKGRTHQVLKTIYNKETGKLEGVMSFMEKKGPLTVTLAECEK IALRFLFALFPNADQYFRIRYDEKDEEENAVAGFTFEAHCHGVPLRFGQIRICVSRQT GYITVYMGPDIDPNKLATIDPVPAISVEQAKSIFWQHFKVELGWEREYGDDEEHSYRL VYKPVYPHFIDAHTGEPVFSIW*" /label="ycdB CDS" gene 282397..283815 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /label="ycdB gene" promotor_-10 complement(283858..283876) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(283866) /Source="Nicolas_upshifts" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(283890..283897) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 283922..284001 /Source="Nicolas_S_feature" /locus_tag="new_302355_302434" /HighExp="ferm, M40t45, M0t45, Lbstat, S0, nit, LBGtran, Lbtran, G135, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S102" upshifts 283922 /Source="Nicolas_upshifts" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="upshifts" promotor_-35 283924..283930 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-35" promotor_-10 283945..283962 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-10" CDS 284002..285363 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388162.1" /db_xref="EnsemblGenomes-Gn:BSU02800" /db_xref="EnsemblGenomes-Tr:CAB12074" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12759" /db_xref="UniProtKB/Swiss-Prot:O34772" /translation="MVNKQLKKKAQEIGNVPTHYELEIEDYDQKQKKYGQAYFIWKDP KDPEKHITVELRNDGALLTFSTTVHSETDKKLPDAELKLTALQFAAANHPGTFMNFHF QGKEERGQHIRFVYTKMELGLPIPNSGFLIDMTRSGQIVHFLYYGEGHKAEVPTEFVA KEKVVSHYLNTMSFELMYDVIDGEQEPRLVYEPILPGYSYPADVDEIVPDQHIADERI ENTAPLPPLQNKEEVDIFALLGFTSDMQKVSERDFGEQIGSTWRRGAAPERKDLSIGS YFETRNKNTIKMKTDKRTGKLKAALSFMDWRNNLQCSTEECQEIALQFLYALYPRAAE FFRVNPVRIDERGRVRNHFSVWYKGVPLRFGAARIIVNPETGLIDAFMAPDIEPEQLE AINHRPDVSAEEAKEAFLAAFDVKLEWQPDFTAGSDQHCKLVYKPVYPSYIDAHIRKK KRL*" /label="ycdC CDS" gene 284002..285363 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /label="ycdC gene" S_feature 285364..285944 /Source="Nicolas_S_feature" /locus_tag="new_303797_304377" /HighExp="ferm, M0t45, G135, G180, H2O2, M40t45, G150, Paraq, S0, nit" /AntisenseName="cwlK" /AntisenseCor="0.27553388443794402" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S103" CDS complement(285371..285874) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17588176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17588176; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="murein L,D:-endopeptidase" /protein_id="NP_388163.1" /db_xref="EnsemblGenomes-Gn:BSU02810" /db_xref="EnsemblGenomes-Tr:CAB12075" /db_xref="GOA:O34360" /db_xref="InterPro:IPR009045" /db_xref="SubtiList:BG12760" /db_xref="UniProtKB/Swiss-Prot:O34360" /translation="MNLPAKTFVILCILFLLDLCFSYIRHEWHSQNALQDMPVPSDLH PIVKQNADALKAAAANKGIDVVITEGFRSFKEQDELYKQGRTKKGNIVTYARGGESYH NYGLAIDFALQKKDGSIIWDMEYDGNQNGKSDWLEVVEIAKTLGFEWGGDWKRFKDYP HLEMIPN*" /label="cwlK CDS" gene complement(285371..285874) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /label="cwlK gene" S_feature complement(285875..285956) /Source="Nicolas_S_feature" /locus_tag="new_304308_304389_c" /HighExp="Cold, T0.30H, LBGstat, C30, T-0.40H, T1.0H, T1.30H, H2O2, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S104" upshifts 285946 /Source="Nicolas_upshifts" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="upshifts" promotor_-10 complement(285948..285967) /Source="Nicolas_upshift_promotors" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 285949..285968 /Source="Nicolas_upshift_promotors" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(285957) /Source="Nicolas_upshifts" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="upshifts" CDS 285997..287118 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388164.1" /db_xref="EnsemblGenomes-Gn:BSU02820" /db_xref="EnsemblGenomes-Tr:CAB12076" /db_xref="GOA:O34327" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:4GYO" /db_xref="SubtiList:BG12663" /db_xref="UniProtKB/Swiss-Prot:O34327" /translation="MRAKIPSEEVAVKLNEWYKLIRAFEADQAEALKQEIEYDLEDME ENQDLLLYFSLMEFRHRIMLDKLMPVKDSDTKPPFSDMLNEIESNQQKLTGLLEYYFY YFRGMYEFKQKNFILAIDHYKHAEEKLEYVEDEIEKAEFLFKVAEVYYHIKQTYFSMN YASQALDIYTKYELYGRRRVQCEFIIAGNLTDVYHHEKALTHLCSALEHARQLEEAYM IAAAYYNVGHCKYSLGDYKEAEGYFKTAAAIFEEHNFQQAVQAVFSLTHIYCKEGKYD KAVEAYDRGIKSAAEWEDDMYLTKFRLIHELYLGSGDLNVLTECFDLLESRQLLADAE DLLHDTAERFNQLEHYESAAFFYRRLMNIKKKLAEQRFQ*" /label="rapJ CDS" gene 285997..287118 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /label="rapJ gene" downshifts 287112 /Source="Nicolas_upshifts" /id="D115" /incds=0 /nref=88 /ntot=228 /MaxReadThrough="3.8438" /MaxDrop="5.06867" /score="32.2653577" /energy="-13.2" /TU="U204" /idTUdmin="U204" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 287159..287165 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 287180..287198 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 287183 /Source="Nicolas_upshifts" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 287225..288001 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388165.1" /db_xref="EnsemblGenomes-Gn:BSU02830" /db_xref="EnsemblGenomes-Tr:CAB12077" /db_xref="GOA:P80869" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12761" /db_xref="UniProtKB/Swiss-Prot:P80869" /translation="MYKDLTGKTAIVTGSSKGIGKAIAERFGKEKMNVVVNYHSDPSG ADETLEIIKQNGGKAVSVEADVSKEEGIQALLDTALEHFGTLDVMVNNSGFNGVEAMP HEMSLEDWQRVIDVNVTGTFLGAKAALNHMMKNNIKGNVLNISSVHQQIPRPVNVQYS TSKGGIKMMTETLALNYADKGIRVNAIAPGTIATESNVDTKKEESRQKQLKKIPMKAF GKPEEVAAAAAWLVSEEASYVTGATLFVDGGMTLYPSQLE*" /label="ycdF CDS" gene 287225..288001 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /label="ycdF gene" downshifts complement(287232) /Source="Nicolas_upshifts" /id="D116" /incds=0 /nref=10 /ntot=23 /MaxReadThrough="0.31912" /MaxDrop="4.8095" /score="0.506500496" /energy="-5.8" /TU="NA" /idTUdmin="U205" /TUdmin="-1914" /isTUend="FALSE" /label="downshifts" CDS 288026..289711 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-carbohydrate hydrolase" /protein_id="NP_388166.1" /db_xref="EnsemblGenomes-Gn:BSU02840" /db_xref="EnsemblGenomes-Tr:CAB12078" /db_xref="GOA:O34364" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12762" /db_xref="UniProtKB/Swiss-Prot:O34364" /translation="MKTDWWKDAVVYQIYPRSFQDSNGDGIGDLRGIISRLDYIKELG ADVIWICPIYPSPNVDYGYDVTNHKAIMDSYGTMDDFHELLDQVHQRGLKLVMDFVLN HTSVEHPWFKEAELDKNSKYRSYYYWRPGTKNGPPTDWLSNYGCPVWQYEEHTGEYYL HMNAVKQADLNWENPEVRQAVYDMMKFWLDKGVDGLRIDQLHLISKKEYLPSYEDYIN QQAEPKPFQPNGERIHDYLKEITDEVFSHYDVMSVGEVGSVTPEEGLKYTGTDKHELN MIFHFQHMELDQQPGKEHWDLKPLELSDLKSVLTKWQKKLEHQGWNTLFWCNHDQPRI VSRFGDDGEYRKASAKMLAAVIYFMKGTPYIYQGEEIGMTNAPFTRIEDYKDIQTINM YHKRVFEKGYDPNDVMRSILAKSRDHARTPMQWNSGKNAGFTDGTPWLKVNPNFTAIN VEEAQGDPDSVLNYYKKLISLRKQYADLMKGSFDLLLPDDPQLFVYMRENSKQQLLSV NNFSKEQAVFQWPKNCGKAQASLLLSNYNNDDLDDEMVFRPYESRVYLLDKTN*" /label="ycdG CDS" gene 288026..289711 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /label="ycdG gene" promotor_no_box 288966..289066 /Source="Nicolas_upshift_promotors" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 289026 /Source="Nicolas_upshifts" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 289092 /Source="Nicolas_upshifts" /id="D117" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.77365" /MaxDrop="2.18547" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=1914 /isTUend="FALSE" /label="downshifts" downshifts 289708 /Source="Nicolas_upshifts" /id="D118" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="5.8252" /MaxDrop="5.18702" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" promotor_-35 289802..289809 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 289825..289844 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 289831 /Source="Nicolas_upshifts" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 289899..290858 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9379902, 12426338, 14730579, 21813502; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="Zn(II)-binding lipoprotein" /protein_id="NP_388167.1" /db_xref="EnsemblGenomes-Gn:BSU02850" /db_xref="EnsemblGenomes-Tr:CAB12079" /db_xref="GOA:O34966" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="PDB:2O1E" /db_xref="SubtiList:BG12763" /db_xref="UniProtKB/Swiss-Prot:O34966" /translation="MFKKWSGLFVIAACFLLVAACGNSSTKGSADSKGDKLHVVTTFY PMYEFTKQIVKDKGDVDLLIPSSVEPHDWEPTPKDIANIQDADLFVYNSEYMETWVPS AEKSMGQGHAVFVNASKGIDLMEGSEEEHEEHDHGEHEHSHAMDPHVWLSPVLAQKEV KNITAQIVKQDPDNKEYYEKNSKEYIAKLQDLDKLYRTTAKKAEKKEFITQHTAFGYL AKEYGLKQVPIAGLSPDQEPSAASLAKLKTYAKEHNVKVIYFEEIASSKVADTLASEI GAKTEVLNTLEGLSKEEQDKGLGYIDIMKQNLDALKDSLLVKS*" /label="znuA CDS" gene 289899..290858 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /label="znuA gene" promotor_-35 290454..290460 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 290474..290493 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 290478 /Source="Nicolas_upshifts" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" downshifts 290830 /Source="Nicolas_upshifts" /id="D119" /incds=0 /nref=140 /ntot=250 /MaxReadThrough="6.07181" /MaxDrop="5.15011" /score="8.99106569" /energy="-15.9" /TU="U206,U208,U209" /idTUdmin="U206" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS 290914..291609 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Zn(II) transporter (ATP-binding protein)" /protein_id="NP_388168.1" /db_xref="EnsemblGenomes-Gn:BSU02860" /db_xref="EnsemblGenomes-Tr:CAB12080" /db_xref="GOA:O34946" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12764" /db_xref="UniProtKB/Swiss-Prot:O34946" /translation="MNLVSLKDIVFGYSHTPVLDKVSLDIESGEFVGITGPNGASKST LIKVMLGMLKPWEGTVTISKRNTEGKRLTIGYVPQQISSFNAGFPSTVLELVQSGRYT KGKWFKRLNEEDHLEVEKALKMVEMWDLRHRKIGDLSGGQKQKICIARMLASNPDLLM LDEPTTAVDYDSRKGFYEFMHHLVKNHNRTVVMVTHEQNEVQQFLDKVIRLERGEKGG WKCLTWNSCDELF*" /label="znuC CDS" gene 290914..291609 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /label="znuC gene" CDS 291567..292409 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity Zn(II) ABC transporter (permease)" /protein_id="NP_388169.1" /db_xref="EnsemblGenomes-Gn:BSU02870" /db_xref="EnsemblGenomes-Tr:CAB12081" /db_xref="GOA:O34610" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12765" /db_xref="UniProtKB/Swiss-Prot:O34610" /translation="MEMFDLEFMRRAFLAGGMIAVMAPILGVYLVLRRQALMADTLSH ISLSGVAIGFFLSTNITAASIVVVTIGAIGIEYMRRAYRTYSEVSIAILMAAGLSFAM FLISLSKGTANMSIDQYLFGSLVTVNQQQVYIISIITLLILLYFIVLRRPLYLLTFDE ATAKTSGINTNVLSLSFSIVTGLAISVIIPIIGVLLVSALLVLPAAFAIRIAKGFNMV FITAILISLFSVFTGLTSSYQLGTPPGPSITLLLIVLLLIGFAVQGVWTFIKKEAQRK KRSR*" /label="znuB CDS" gene 291567..292409 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /label="znuB gene" downshifts 292396 /Source="Nicolas_upshifts" /id="D120" /incds=0 /nref=168 /ntot=266 /MaxReadThrough="2.4865" /MaxDrop="6.44929" /score="27.8218406" /energy="-13.6" /TU="NA" /idTUdmin="U206" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(292447..293442) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16428414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative luciferase-like monooxygenase" /protein_id="NP_388170.2" /db_xref="EnsemblGenomes-Gn:BSU02880" /db_xref="EnsemblGenomes-Tr:CAB12082" /db_xref="GOA:O34504" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12766" /db_xref="UniProtKB/Swiss-Prot:O34504" /translation="MIHLSILDQAPVSKGESPVTTLQHSVELAQLSEQWGYKRYWFAE HHSTKGLASTAPEIMIARIAAQTNTIRVGSGGVLLPQYSPFKVAETFRQLEALYPNRI DLGVGRSPGGTTKTRLALTDGVKKSLTEFNRQLQDVSYFLTDSLPPDHPYAGIKAAPL IGTAPELWVLGLGENSARRAAHQGIGYVFGHFINPERGENAFRIYRESFRPSAHFSNP SALFTIFVICAKTDEEAEELALSQDLWLLRVGKGLDSRVPSIEEAKAHPYTASDKKLI EENRKRMVIGSPTTVKQQLLDLTGCYETNEIMVLCNVFDFEAKKESYERLAELFL*" /label="yceB CDS" gene complement(292447..293442) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /label="yceB gene" promotor_-35 293398..293405 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-35" promotor_-10 293420..293439 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-10" S_feature 293426..293628 /Source="Nicolas_S_feature" /locus_tag="new_311859_312061" /HighExp="Diami, Etha, dia5, Salt, H2O2, dia15, Paraq, T-0.40H, T0.30H, G135" /AntisenseName="yceB" /AntisenseCor="0.84300534435872998" /AntisenseRegPval="-73.099999999999994" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S105" upshifts 293426 /Source="Nicolas_upshifts" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="upshifts" promotor_-10 complement(293474..293493) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(293482) /Source="Nicolas_upshifts" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(293508..293515) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 293612..293621 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 293630..293725 /Source="Nicolas_S_feature" /locus_tag="new_312063_312158" /HighExp="T0.0H, T-0.40H, T-1.10H, T0.30H, Salt, T1.0H, Etha, T-1.40H, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S106" upshifts 293630 /Source="Nicolas_upshifts" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 293634..293649 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 293726..294325 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388171.1" /db_xref="EnsemblGenomes-Gn:BSU02890" /db_xref="EnsemblGenomes-Tr:CAB12083" /db_xref="GOA:P81100" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12767" /db_xref="UniProtKB/Swiss-Prot:P81100" /translation="MAISLEKGQRIDLTKGKAGLSKLMVGLGWDPVSSGGGFFSKLLG GGGPNIDCDASVLMLENGKFTDKKNLIYFGNLKSRCGGVQHTGDNLTGDGAGDDEQIM IDLDKVPGNIDKLVFVVNIYDCVRRKQDFGMIQNAFIRVVDQSNHEEMLKYNLRDNYA GRTSLITAEIYRSGSEWKFAAVGEGTNDTRLEDIISRYV*" /label="yceC CDS" gene 293726..294325 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /label="yceC gene" CDS 294347..294928 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388172.1" /db_xref="EnsemblGenomes-Gn:BSU02900" /db_xref="EnsemblGenomes-Tr:CAB12084" /db_xref="GOA:P80875" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12768" /db_xref="UniProtKB/Swiss-Prot:P80875" /translation="MTISLAKGQKVDLTKTNPGLSKVVVGLGWDTNKYDGGHDFDLDS SVFLLDAAGKCASPNDFIFYNQLEGGNGSVVHSGDNLTGAGEGDDENVKVNLSAVPAN IDKISFVITIHDAEARSQNFGQVSNAFVRIVNEETNEELIRYDLAEDFSIETAIIAGE LYRHNGEWKFSAIGSGYQGGLARIATDYGLQVG*" /label="yceD CDS" gene 294347..294928 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /label="yceD gene" CDS 294963..295541 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388173.1" /db_xref="EnsemblGenomes-Gn:BSU02910" /db_xref="EnsemblGenomes-Tr:CAB12085" /db_xref="GOA:O34384" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12769" /db_xref="UniProtKB/Swiss-Prot:O34384" /translation="MAIQLSKGQRIDLTKTNPGLTKAVIGLGWDTNKYSGGHDFDLDA SAFLVDAHDNCVNDLDFVFYNNLEHPSGGVIHTGDNRTGEGDGDDEQIIVDFSKIPAH IEKIGITVTIHDAEARSQNFGQVSNAFVRVVDEETQNELLRFDLGEDFSIETAVVVCE LYRHGGEWKFNAIGSGFSGGLAALCRNYGLQV*" /label="yceE CDS" gene 294963..295541 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /label="yceE gene" CDS 295592..296365 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 24366250; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative stress adaptation transporter (tellurite resistance)" /protein_id="NP_388174.1" /db_xref="EnsemblGenomes-Gn:BSU02920" /db_xref="EnsemblGenomes-Tr:CAB12086" /db_xref="GOA:O34447" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="SubtiList:BG12770" /db_xref="UniProtKB/Swiss-Prot:O34447" /translation="MDFLHHILSTYASFFDWKMWGEVLTDPVSWGLIGSLVVLEGLLS ADNALVLAVMVKHLPEKQRKKALTYGLFGAYIFRFIFIGLGMLLIKFWWIKVLGALYL AWLVIKHFWIGEKEEEADGMKKNSWMVRTFGIFWATVISVELMDLAFSVDSILAAFAV SEKVWVLLIGGMLGILMMRTVAKVFLVLIDKIPELENTAFVLIGIIALKMAGSAFHYE MPHSVFFIIIIAAFAVTLIIHYINKQKQVREQTAASKEE*" /label="yceF CDS" gene 295592..296365 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /label="yceF gene" downshifts 296352 /Source="Nicolas_upshifts" /id="D121" /incds=0 /nref=46 /ntot=239 /MaxReadThrough="6.82513" /MaxDrop="4.0674" /score="4.0495978" /energy="-8.2" /TU="U212" /idTUdmin="U210" /TUdmin=2728 /isTUend="FALSE" /label="downshifts" CDS 296450..298063 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxic compound adaptation protein (tellurite resistance)" /protein_id="NP_388175.1" /db_xref="EnsemblGenomes-Gn:BSU02930" /db_xref="EnsemblGenomes-Tr:CAB12087" /db_xref="InterPro:IPR025647" /db_xref="SubtiList:BG12771" /db_xref="UniProtKB/Swiss-Prot:O34809" /translation="MRQEELTIHKALPADGDWKSLLFQPLPERDHYETAQGLSFSRLA GQILGTPIDETDYYNELYELSVNDRITILSETLDKTIEPETFQKLQHIHSINQKEKGL SVSRFVAFLDGEKLIAKHSNPLMHRHLRKALMTLLHTFADSHEKGLNHPDFRRVLLDV SKFSLNHLNPWLEKTDIEREMPKVVWYGDATKSQLYFLYYLMLVGCDVLLFHPAGTDQ LALVDPKQELGFTEKLPDVSELQPFPKEKPDRKSTVAYRSTKEIEHVLNHEESMLYKP WQFRDHTPVSVTLKTTYDELFLITKERAFIRPNFKADKHSIEIPNVFAKIMGVSKDNK EYWNRLHTLADYQETEMVRSFPFTEEIKSNYQFHYSHALDQEGNIDPDKLMASNVWQY KQLPAGVQTAIAKTISRMCRYPRLKALHQEQVKDVQIYLFKQTTNLPANLLKLIQMFD YAQTVPKLVLYHTEMSGGLTRSDAAALLFLNEIGIDIIIYNPPGHQDIEQFIEEDQYD IHWLDDMVFQQDYKEPSLVKRLFRTITQK*" /label="yceG CDS" gene 296450..298063 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /label="yceG gene" CDS 298079..299170 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative reactive oxygen species resistance protein" /protein_id="NP_388176.1" /db_xref="EnsemblGenomes-Gn:BSU02940" /db_xref="EnsemblGenomes-Tr:CAB12088" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG12772" /db_xref="UniProtKB/Swiss-Prot:O34833" /translation="MTTENQNPLVLDKNEEISQQKADDIRLQLRQEPEVKRLAQQIDV KNQMELLEYGKEPAVEISKFSDRILGMMKTTSVTDSGTMLTQLGKIMDRFDKNDFDEP KGLMAKIFKRGGSMIEKIFKKYQTLGGEIEKIHVEISKYKDEMTKTNYTLDEMYENNI KYYMELEKYVVAGQMKLEEMQSILPSYEEKAASGNQLAQMQLDTLRNGIQALEERVYD LDMARMVALQTAPQIRLLQRGNAKLIGKINSAFIITIPIFKNGIIQAVTVKRQKLVAD SMSELDRRTNEMLKRNAENISSQSVEIARMAGRPSIDIETIESSWNTIVSGMQETKQI EEENKRLREDGARRIAQLQDNIKKAALQQ*" /label="yceH CDS" gene 298079..299170 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /label="yceH gene" downshifts 299144 /Source="Nicolas_upshifts" /id="D122" /incds=0 /nref=85 /ntot=228 /MaxReadThrough="4.46836" /MaxDrop="4.05585" /score="-6.59172775" /energy="-17.5" /TU="U212" /idTUdmin="U212" /TUdmin="-1322" /isTUend="FALSE" /label="downshifts" promotor_-35 299224..299231 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 299246..299265 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 299254 /Source="Nicolas_upshifts" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="upshifts" CDS 299292..300494 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18276644, 21953179" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18276644, 21953179; Product type t: transporter" /codon_start=1 /transl_table=11 /product="niacin permease" /protein_id="NP_388177.1" /db_xref="EnsemblGenomes-Gn:BSU02950" /db_xref="EnsemblGenomes-Tr:CAB12089" /db_xref="GOA:O34691" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12773" /db_xref="UniProtKB/Swiss-Prot:O34691" /translation="MGKQQPISQRKLLGVAGLGWLFDAMDVGILSFIIAALHVEWNLS PEEMKWIGSVNSIGMAAGAFLFGLLADRIGRKKVFIITLLCFSIGSGISAFVTSLSAF LILRFVIGMGLGGELPVASTLVSEAVVPEKRGRVIVLLESFWAVGWLAAALISYFVIP SFGWQAALLLTALTAFYALYLRTSLPDSPKYESLSAKKRSMWENVKSVWARQYIRPTV MLSIVWFCVVFSYYGMFLWLPSVMLLKGFSMIQSFEYVLLMTLAQLPGYFSAAWLIEK AGRKWILVVYLIGTAGSAYFFGTADSLSLLLTAGVLLSFFNLGAWGVLYAYTPEQYPT AIRATGSGTTAAFGRIGGIFGPLLVGTLAARHISFSVIFSIFCIAILLAVACILIMGK ETKQTELE*" /label="niaP CDS" gene 299292..300494 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /label="niaP gene" downshifts 300474 /Source="Nicolas_upshifts" /id="D123" /incds=0 /nref=8 /ntot=184 /MaxReadThrough="4.1968" /MaxDrop="3.48367" /score="13.0427769" /energy="-10.6" /TU="U213" /idTUdmin="U212" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(300747..301919) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate transporter (possibly exporter)" /protein_id="NP_388178.1" /db_xref="EnsemblGenomes-Gn:BSU02960" /db_xref="EnsemblGenomes-Tr:CAB12090" /db_xref="GOA:O34724" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12774" /db_xref="UniProtKB/Swiss-Prot:O34724" /translation="MNRIWLFFSVMFVIGTDTFLLSPLLPLLQDQFHVSTDLSGWMVS AYALGYALFAFIAGPISDRLNRKTVMLWGLAGFIVSTFLCGIAPSFAAMCLFRFAAGV SAAFVTPQIWASIPVIVQPSQIIKGMGIATAGLAASQMLGLPIGGFLASFTWHTPFFV LSACSLILLLILAAVMPGIRPSEPLARPSIVNPYRELFSLPKTSVILLAYFLFQTGNF ASFSFLGTWLSADYHLTVSQIGAAMLVLGLGNMLGSLIGSRVSEKLGMFKTLISGMLL MGALYFALPFFPNLFLVEAGFFLTFFTAGIIFPLMMGVFQSIAPNARGTIASLSNAAM YAGTTVGTSIAGFLYQSTQHFGAVTGFTAILFILSMTLYQTISKTGKRQSTARAQL*" /label="yceJ CDS" gene complement(300747..301919) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /label="yceJ gene" downshifts complement(300762) /Source="Nicolas_upshifts" /id="D124" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="2.6211" /MaxDrop="2.7452" /score="9.21991741" /energy="-12.6" /TU="NA" /idTUdmin="U214" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(301988..302290) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388179.1" /db_xref="EnsemblGenomes-Gn:BSU02970" /db_xref="EnsemblGenomes-Tr:CAB12091" /db_xref="GOA:O34464" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12775" /db_xref="UniProtKB/Swiss-Prot:O34464" /translation="MYYSFMTMKQSDDQIRAQIFKALSDESRLAIIRTLYVSGKELSC GEVGEKCNIVKTTASYHFKTLREAGLTATRKDSRTKYVSLREDTFQTYLPGFLETL*" /label="yceK CDS" gene complement(301988..302290) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /label="yceK gene" downshifts complement(302016) /Source="Nicolas_upshifts" /id="D125" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="5.67096" /MaxDrop="6.89889" /score="2.01231069" /energy="-4.8" /TU="U214" /idTUdmin="U214" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(302273..302292) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(302292) /Source="Nicolas_upshifts" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(302306..302312) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 302539..302558 /Source="Nicolas_upshift_promotors" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 302539 /Source="Nicolas_upshifts" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="upshifts" CDS 302580..303836 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(ATP-binding protein)" /protein_id="NP_388180.2" /db_xref="EnsemblGenomes-Gn:BSU02980" /db_xref="EnsemblGenomes-Tr:CAB12092" /db_xref="GOA:P46920" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11370" /db_xref="UniProtKB/Swiss-Prot:P46920" /translation="MSVDEKPIKIKVEKVSKIFGKQTKKAVQMLANGKTKKEILKATG STVGVNQADFEVYDGEIFVIMGLSGSGKSTLVRMLNRLIEPTAGNIYIDGDMITNMSK DQLREVRRKKISMVFQKFALFPHRTILENTEYGLELQGVDKQERQQKALESLKLVGLE GFEHQYPDQLSGGMQQRVGLARALTNDPDILLMDEAFSALDPLIRKDMQDELLDLHDN VGKTIIFITHDLDEALRIGDRIVLMKDGNIVQIGTPEEILMNPSNEYVEKFVEDVDLS KVLTAGHIMKRAETVRIDKGPRVALTLMKNLGISSIYAVDKQKKLLGVIYASDAKKAA ESDLSLQDILNTEFTTVPENTYLTEIFDVVSDANIPIAVVDEKQRMKGIVVRGALIGA LAGNNEYINAEGTNEQTQDPSAQEVK*" /label="opuAA CDS" gene 302580..303836 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /label="opuAA gene" downshifts complement(302588) /Source="Nicolas_upshifts" /id="D126" /incds=0 /nref=108 /ntot=175 /MaxReadThrough="2.83797" /MaxDrop="5.18503" /score="2.01231069" /energy="-4.8" /TU="NA" /idTUdmin="U214" /TUdmin="-1826" /isTUend="FALSE" /label="downshifts" CDS 303838..304686 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752321, 15849754, 16225868, 16645306, 16850406, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752321, 15849754, 16225868, 16645306, 16850406, 25012968; Product type t : transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(permease)" /protein_id="NP_388181.1" /db_xref="EnsemblGenomes-Gn:BSU02990" /db_xref="EnsemblGenomes-Tr:CAB12093" /db_xref="GOA:P46921" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11371" /db_xref="UniProtKB/Swiss-Prot:P46921" /translation="MDRLPRIPLADIIDRFVDWITMTFGGFFDGIANGLAAFVNGIVT GLGFIPSILLTIIFAALAWWISTRGIALFTLIGFLLIDYLGYWDPMLQTLALVLTSVI ISIVVGVPIGIWASQKETVRRIVTPILDLMQTMPAFVYLLPAIFFFNIGVVPGVVASV IFAMPPTIRMTVLGIKQVPADLIEATEAFGSTTAQRLFKVQLPLATKTILAGINQSIM LALSMVVIAAMVGAPGLGSEVYSAVTQLKTGVGVEAGIAIVIVAITLDRITQNIKVKK KSRGNA*" /label="opuAB CDS" gene 303838..304686 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /label="opuAB gene" CDS 304686..305567 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporterABC transporter (glycine betaine-binding lipoprotein)" /protein_id="NP_388182.1" /db_xref="EnsemblGenomes-Gn:BSU03000" /db_xref="EnsemblGenomes-Tr:CAB12094" /db_xref="GOA:P46922" /db_xref="InterPro:IPR007210" /db_xref="PDB:2B4L" /db_xref="PDB:2B4M" /db_xref="PDB:3CHG" /db_xref="SubtiList:BG11372" /db_xref="UniProtKB/Swiss-Prot:P46922" /translation="MLKKIIGIGVSAMLALSLAACGSENDENASAAEQVNKTIIGIDP GSGIMSLTDKAMKDYDLNDWTLISASSAAMTATLKKSYDRKKPIIITGWTPHWMFSRY KLKYLDDPKQSYGSAEEIHTITRKGFSKEQPNAAKLLSQFKWTQDEMGEIMIKVEEGE KPAKVAAEYVNKHKDQIAEWTKGVQKVKGDKINLAYVAWDSEIASTNVIGKVLEDLGY EVTLTQVEAGPMWTAIATGSADASLSAWLPNTHKAYAAKYKGKYDDIGTSMTGVKMGL VVPQYMKNVNSIEDLKK*" /label="opuAC CDS" gene 304686..305567 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /label="opuAC gene" downshifts 305548 /Source="Nicolas_upshifts" /id="D127" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="0.74967" /MaxDrop="8.21394" /score="33.6263027" /energy="-12.2" /TU="NA" /idTUdmin="U215" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(305580) /Source="Nicolas_upshifts" /id="D128" /incds=0 /nref=2 /ntot=62 /MaxReadThrough="4.29566" /MaxDrop="3.9514" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(305605..306756) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8768514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388183.2" /db_xref="EnsemblGenomes-Gn:BSU03010" /db_xref="EnsemblGenomes-Tr:CAB12095" /db_xref="GOA:P54983" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11789" /db_xref="UniProtKB/Swiss-Prot:P54983" /translation="MQKLSEEMKQTIMDIFEHLHANPEVSWKEYETTSFLKQKLEDLG CRTRTFSDCTGVVGEIGSGSPVVAVRADIDALWQEVNGTFRANHSCGHDSHMTMALGT LMLLKKQPELPKGTIRFIFQPAEEKGGGALKMIEEGVLDDIDYLYGVHVRPIQETQNG RCAPSILHGSSQHIEGTIIGEEAHGARPHLGKNSIEIAAFLVHKLGLIHIDPQIPHTV KMTKLQAGGESSNIIPGKASFSLDLRAQTNEAMEALIAETERACEAAAAAFGAKIELH KEHSLPAATQNKEAEAIMAEAITEIIGAERLDDPLVTTGGEDFHFYAVKVPNLKTTML GLGCGLQPGLHHPHMTFDRNAMFTGIHILANAVLKTFQKAESLAAANAS*" /label="amhX CDS" gene complement(305605..306756) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /label="amhX gene" downshifts complement(305624) /Source="Nicolas_upshifts" /id="D129" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="4.33606" /MaxDrop="3.5225" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" S_feature complement(306757..306844) /Source="Nicolas_S_feature" /locus_tag="new_325190_325277_c" /HighExp="Etha, T1.30H, M9-stat, T2.30H, S1, T3.30H, T5.0H, T4.0H, Sw, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S107" promotor_-35 306812..306819 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-35" promotor_-10 complement(306831..306850) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 306834..306853 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-10" upshifts complement(306844) /Source="Nicolas_upshifts" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="upshifts" upshifts 306847 /Source="Nicolas_upshifts" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="upshifts" promotor_-35 complement(306863..306869) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 306906..308339 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21747963, 21764931; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative branched chain amino acid permease" /protein_id="NP_388184.2" /db_xref="EnsemblGenomes-Gn:BSU03020" /db_xref="EnsemblGenomes-Tr:CAB12096" /db_xref="GOA:P55908" /db_xref="InterPro:IPR018385" /db_xref="SubtiList:BG11999" /db_xref="UniProtKB/Swiss-Prot:P55908" /translation="MSMPAAETQPKKKRMTFKMPDAYVLLFMIAFICAIASYIVPAGE FDRVTKGDVTTAVPGSYHSIEQSPVRLISFFTSLQDGMVGSAPIIFLILFTGGTIAIL EKTGAINGLIYNVISKFRTKQLLFICIVGALFSILGTTGIVVNSVIGFIPIGLIVARS LKWDAVAGAAVIYIGCYAGFNSTILSPSPLGLSQSIAELPLFSGIGLRVVIYICFLLS SIIYIYLYTRKLKKSKDASVLGTDWFPAAGMGEAGKEEDQSVPFTVRHKLILAVAGLS LVGFLYGALKLGWSDSQMAATFIFISVLAGLIGGLAANDIAKTFITGCQSLVYGALIV GMARSISVILENGKLLDTVVNALASLLDGFSPIAGAIGMYIASALLHFLISSGSGEAV VFIPILAPLADLMGITRQVAVEAVMLGEGVVNCVNPTSGVLMAVLAASGIPYVKWLRF MVPLALIWFLIGLVFIVIGVMINWGPF*" /label="ycgA CDS" gene 306906..308339 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /label="ycgA gene" promotor_-35 307644..307652 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 307664..307682 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 307683 /Source="Nicolas_upshifts" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 308321 /Source="Nicolas_upshifts" /id="D130" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="3.53497" /MaxDrop="3.31444" /score="12.0135493" /energy="-15.6" /TU="U217" /idTUdmin="U218" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 308382..308389 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 308404..308423 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 308413 /Source="Nicolas_upshifts" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 308455..309036 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406, 22720735; Producttype m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_388185.2" /db_xref="EnsemblGenomes-Gn:BSU03030" /db_xref="EnsemblGenomes-Tr:CAB12097" /db_xref="SubtiList:BG12000" /db_xref="UniProtKB/Swiss-Prot:P55909" /translation="MNNLRNRLSGVNGKNKRVKEKEQKIWSEIGMIAGAFALLDVIIR GIMFEFPFKEWAASLVFLFIIILYYCIRAAASGMLMPRIDTKEELQKRVKQQRIESIA VAFAVVVLTMYDRGIPHTFFAWLKMILLFIVCGGVLFLLRYVIVKLAYRRAVKEEIKK KSSFLFGKRGKRSQFRAAFFIGTLICIHSAKLF*" /label="ycgB CDS" gene 308455..309036 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /label="ycgB gene" upshifts 308849 /Source="Nicolas_upshifts" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" misc_feature 308853..308857 /Source="Nicolas_upshift_promotors" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 309012..309019 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 309034..309053 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 309047..309184 /Source="Nicolas_S_feature" /locus_tag="new_327480_327617" /HighExp="BC, M0t90, M40t90, S2, M9-stat, T4.0H, Sw, T3.30H, Lbtran, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.999, 0.242, 0.999" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S108" upshifts 309047 /Source="Nicolas_upshifts" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 309185..311164 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /EC_number="3.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3117969, 9353930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3117969, 9353930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-amylase" /protein_id="NP_388186.2" /db_xref="EnsemblGenomes-Gn:BSU03040" /db_xref="EnsemblGenomes-Tr:CAB12098" /db_xref="GOA:P00691" /db_xref="InterPro:IPR006046" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR031319" /db_xref="InterPro:IPR031965" /db_xref="PDB:1BAG" /db_xref="PDB:1UA7" /db_xref="SubtiList:BG10473" /db_xref="UniProtKB/Swiss-Prot:P00691" /translation="MFAKRFKTSLLPLFAGFLLLFHLVLAGPAAASAETANKSNELTA PSIKSGTILHAWNWSFNTLKHNMKDIHDAGYTAIQTSPINQVKEGNQGDKSMSNWYWL YQPTSYQIGNRYLGTEQEFKEMCAAAEEYGIKVIVDAVINHTTSDYAAISNEVKSIPN WTHGNTQIKNWSDRWDVTQNSLLGLYDWNTQNTQVQSYLKRFLDRALNDGADGFRFDA AKHIELPDDGSYGSQFWPNITNTSAEFQYGEILQDSASRDAAYANYMDVTASNYGHSI RSALKNRNLGVSNISHYASDVSADKLVTWVESHDTYANDDEESTWMSDDDIRLGWAVI ASRSGSTPLFFSRPEGGGNGVRFPGKSQIGDRGSALFEDQAITAVNRFHNVMAGQPEE LSNPNGNNQIFMNQRGSHGVVLANAGSSSVSINTATKLPDGRYDNKAGAGSFQVNDGK LTGTINARSVAVLYPDDIAKAPHVFLENYKTGVTHSFNDQLTITLRADANTTKAVYQI NNGPETAFKDGDQFTIGKGDPFGKTYTIMLKGTNSDGVTRTEKYSFVKRDPASAKTIG YQNPNHWSQVNAYIYKHDGSRVIELTGSWPGKPMTKNADGIYTLTLPADTDTTNAKVI FNNGSAQVPGQNQPGFDYVLNGLYNDSGLSGSLPH*" /label="amyE CDS" gene 309185..311164 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /label="amyE gene" downshifts 311178 /Source="Nicolas_upshifts" /id="D131" /incds=0 /nref=57 /ntot=131 /MaxReadThrough="1.64783" /MaxDrop="6.55823" /score="-8.82332571" /energy="-3.4" /TU="U221" /idTUdmin="U219" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 311244..311251 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 311261 /Source="Nicolas_upshifts" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 311265..311284 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 311341..312306 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /EC_number="1.1.1.27" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10809684, 16207915, 19383131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 16207915, 19383131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lactate dehydrogenase" /protein_id="NP_388187.2" /db_xref="EnsemblGenomes-Gn:BSU03050" /db_xref="EnsemblGenomes-Tr:CAB12099" /db_xref="GOA:P13714" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011304" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR018177" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="PDB:3PQD" /db_xref="PDB:3PQE" /db_xref="PDB:3PQF" /db_xref="SubtiList:BG19003" /db_xref="UniProtKB/Swiss-Prot:P13714" /translation="MMNKHVNKVALIGAGFVGSSYAFALINQGITDELVVIDVNKEKA MGDVMDLNHGKAFAPQPVKTSYGTYEDCKDADIVCICAGANQKPGETRLELVEKNLKI FKGIVSEVMASGFDGIFLVATNPVDILTYATWKFSGLPKERVIGSGTTLDSARFRFML SEYFGAAPQNVHAHIIGEHGDTELPVWSHANVGGVPVSELVEKNDAYKQEELDQIVDD VKNAAYHIIEKKGATYYGVAMSLARITKAILHNENSILTVSTYLDGQYGADDVYIGVP AVVNRGGIAGITELNLNEKEKEQFLHSAGVLKNILKPHFAEQKVN*" /label="lctE CDS" gene 311341..312306 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /label="lctE gene" CDS 312338..313963 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10809684, 15849754, 16428414, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 15849754, 16428414, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_388188.2" /db_xref="EnsemblGenomes-Gn:BSU03060" /db_xref="EnsemblGenomes-Tr:CAB12100" /db_xref="GOA:P55910" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG12001" /db_xref="UniProtKB/Swiss-Prot:P55910" /translation="MWEQLYDPFGNEYVSALVALTPILFFLLALTVLKMKGILAAFLT LAVSFFVSVWAFHMPVEKAISSVLLGIGSGLWPIGYIVLMAVWLYKIAVKTGKFTIIR SSIAGISPDQRLQLLLIGFCFNAFLEGAAGFGVPIAISAALLVELGFKPLKAAALCLI ANAASGAFGAIGIPVITGAQIGDLSALELSRTLMWTLPMISFLIPFLLVFLLDRMKGI KQTWPALLVVSGGYTAVQTLTMAVLGPELANILAALFSMGGLALFLRKWQPKEIYREE GAGDAGEKKAYRAADIAKAWSPFYILTAAITIWSLPAFKALFQEGGLLYQSTLLFKMP FLHQQIMKMPPIAPSAMPLDAVFKVDLLSATGTAILAAVIVTGLFSKKFSSRDAFASL KETGKELWVPIMTICFVMGFANLANFAGLSSSIGLALAKTGDLFPFVSPVLGWIGVFI TGSVVSNNALFGHLQVVTGAQIGAGSDLLLAANTAGGVMAKLVSPQSIAIAAAAVGQT GKESKLFKRTVAYSLILLLIICIWTFILARLGV*" /label="lctP CDS" gene 312338..313963 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /label="lctP gene" downshifts 312344 /Source="Nicolas_upshifts" /id="D132" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="8.56142" /MaxDrop="2.8862" /score="-8.82332571" /energy="-3.4" /TU="U222" /idTUdmin="U221" /TUdmin=1144 /isTUend="FALSE" /label="downshifts" downshifts 313950 /Source="Nicolas_upshifts" /id="D133" /incds=0 /nref=51 /ntot=118 /MaxReadThrough="2.31168" /MaxDrop="7.73065" /score="39.575264" /energy="-15.6" /TU="NA" /idTUdmin="U222" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(314008..315546) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9023234, 15489457, 15849754, 16850406, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023234, 15489457, 15849754, 16850406, 21690368; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_388189.2" /db_xref="EnsemblGenomes-Gn:BSU03070" /db_xref="EnsemblGenomes-Tr:CAB12101" /db_xref="GOA:P96712" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12002" /db_xref="UniProtKB/Swiss-Prot:P96712" /translation="MDTTTAKQASTKFVVLGLLLGILMSAMDNTIVATAMGNIVADLG SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLIFFLIGSALCGIAQTMNQ LIIFRAIQGIGGGALLPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGAIIT DSISWHWVFYINVPIGALSLFFIIRYYKESLEHRKQKIDWGGAITLVVSIVCLMFALE LGGKTYDWNSIQIIGLFIVFAVFFIAFFIVERKAEEPIISFWMFKNRLFATAQILAFL YGGTFIILAVFIPIFVQAVYGSSATSAGFILTPMMIGSVIGSMIGGIFQTKASFRNLM LISVIAFFIGMLLLSNMTPDTARVWLTVFMMISGFGVGFNFSLLPAASMNDLEPRFRG TANSTNSFLRSFGMTLGVTIFGTVQTNVFTNKLNDAFSGMKGSAGSGAAQNIGDPQEI FQAGTRSQIPDAILNRIIDAMSSSITYVFLLALIPIVLAAVTILFMGKARVKTTAEMT KKAN*" /label="mdr CDS" gene complement(314008..315546) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /label="mdr gene" downshifts complement(314026) /Source="Nicolas_upshifts" /id="D134" /incds=0 /nref=70 /ntot=182 /MaxReadThrough="1.04964" /MaxDrop="4.53635" /score="30.8374042" /energy="-15.6" /TU="NA" /idTUdmin="U225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(314600..314700) /Source="Nicolas_upshift_promotors" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(314640) /Source="Nicolas_upshifts" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 315560..315564 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 315580..315599 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 315594 /Source="Nicolas_upshifts" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(315626..315645) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(315629) /Source="Nicolas_upshifts" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="upshifts" CDS 315659..316123 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388190.2" /db_xref="EnsemblGenomes-Gn:BSU03080" /db_xref="EnsemblGenomes-Tr:CAB12102" /db_xref="GOA:O31472" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12003" /db_xref="UniProtKB/Swiss-Prot:O31472" /translation="MSTRNSRSELEKTAVQLFRKLGTRTVLFHQAAAQALGLFPTDLK SADILNEAGPMTAGELGKKTGLSTGSVTALVDRLEKAGYVAREKDPNDRRRVVIVPLT ASKKHIKDLFRPLSESTMDLCREYTEEELELIFSFVGKAADIMEEELERLKQ*" /label="ycgE CDS" gene 315659..316123 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /label="ycgE gene" promotor_-35 complement(315660..315666) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 316133..316138 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 316154..316172 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 316164 /Source="Nicolas_upshifts" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 316197..316826 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid export permease" /protein_id="NP_388191.1" /db_xref="EnsemblGenomes-Gn:BSU03090" /db_xref="EnsemblGenomes-Tr:CAB12103" /db_xref="GOA:P94381" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG12004" /db_xref="UniProtKB/Swiss-Prot:P94381" /translation="MNIFLSYIVLGLSLSAPVGPVNAAQIDKGIKNGFWHAWIFGLGA MTADGLYMLFIYFGLSQFLTAPFVKTFLWLFGFFVLTYTGIETLKNVREPMDVRSSRG KPSYRKTFASGFLISLSNPLSILFWLGIYGSILAKTAEAYNMNQLLIYSSGIMIGILI WDFCMAITASTFRNLLHEKLLRGLTGIAGVSLLVFGFYFGYQGIKQLLG*" /label="ycgF CDS" gene 316197..316826 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /label="ycgF gene" promotor_-35 316837..316846 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 316860..316879 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 316868 /Source="Nicolas_upshifts" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 316896..317657 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (similar to phage protein)" /protein_id="NP_388192.2" /db_xref="EnsemblGenomes-Gn:BSU03100" /db_xref="EnsemblGenomes-Tr:CAB12104" /db_xref="InterPro:IPR014988" /db_xref="SubtiList:BG12005" /db_xref="UniProtKB/Swiss-Prot:P94382" /translation="MVNGIYTKSFLERIQEELPEWQRIAFELLAETLGDDADTFPCIP GRQAFLTDQLRIAFAGDPRENRTAEELAPLLAEYGKISRDTGKYASLVVLFDTPEDLA EHYSIEAYEELFWRFLNRLSHQDEKEWPEDIPADPEHYKWEFCFDGEPYFILCATPGH EARRSRSFPFFMVTFQPRWVFDDLNGSTAFGRNMSRLIRSRLEAYDQAPIHPQLGWYG GKDNREWKQYFLRDDEKQVSKCPFSYLKNMFNKMK*" /label="ycgG CDS" gene 316896..317657 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /label="ycgG gene" S_feature complement(317296..317658) /Source="Nicolas_S_feature" /locus_tag="new_335729_336091_c" /HighExp="S8, S7, S5, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="ycgG" /AntisenseCor="0.73875580854115197" /AntisenseRegPval="-46.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S109" downshifts 317654 /Source="Nicolas_upshifts" /id="D135" /incds=0 /nref=21 /ntot=174 /MaxReadThrough="1.53211" /MaxDrop="4.92685" /score="6.36985882" /energy="-8.6" /TU="NA" /idTUdmin="U227" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(317659..318999) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid transporter" /protein_id="NP_388193.2" /db_xref="EnsemblGenomes-Gn:BSU03110" /db_xref="EnsemblGenomes-Tr:CAB12105" /db_xref="GOA:P94383" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12006" /db_xref="UniProtKB/Swiss-Prot:P94383" /translation="MSQTKKDQPKGNLAWWQLSLIGVGCTIGTGFFLGSSIAIVKSGF SVLLSFLIAGIGTYFVFEQLAKLSAKQPEKGSFCAYARKAFGKWAGFSNGWVYWTSEM LITGSQLTAISLFTKHWFPQVPLWVFASIYAVLGLLIIFTGLSVFEKTENVLAVIKTA AIFMFIVIAILALCGILSGGNHGIHVPNKTSEFFPYGAMGLWTGLIYAFYAFGGIEVM GLMAVHLKKPEEASKSGKLMLATLAIIYIISIGLALLLVPLHTFTEQDSPFITSLKGY NLEIILDIFNGIFIIAGFSTLVASLFAVTTLLCTMADDGDAPKCFTLKEGKKICWPAL GLTFAGLVLSIILSLVLPKNIYEHMTTAAGLMLLYTWLFILFSSKKLTDPEGMGKTQI YLAMVLIAAAVSGTLFEKSSRPGFFVSIGFLVIIAIVTMIYQKKQGHKDRPASP*" /label="ycgH CDS" gene complement(317659..318999) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /label="ycgH gene" promotor_-10 complement(319026..319037) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(319036) /Source="Nicolas_upshifts" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(319052..319058) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 319078..319084 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 319092 /Source="Nicolas_upshifts" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 319099..319110 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 319129..319725 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16433904, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388194.3" /db_xref="EnsemblGenomes-Gn:BSU03120" /db_xref="EnsemblGenomes-Tr:CAB12106" /db_xref="InterPro:IPR018959" /db_xref="SubtiList:BG12007" /db_xref="UniProtKB/Swiss-Prot:O31473" /translation="MTQQYIVEPKKGLGLKLKKGQILKVVDVEGQQVADFVAYHAKDF YEHLDQGATIDANHSIHVKVNDHLYSNLYKPMLTLIEDTVGKHDLLLPACRPDMNRLL YGKQKDEFQDTCYDNMNRALEQFGVPKPHMHYPFAIFMNTVLDEKGNLSVETPLSNAG DYVRLRAEMDLIVAFSSCPIEKGKCNGDSVTSIRVEVS*" /label="ycgI CDS" gene 319129..319725 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /label="ycgI gene" promotor_-35 319733..319740 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 319754..319854 /Source="Nicolas_S_feature" /locus_tag="new_338187_338287" /HighExp="dia15, LBGtran, dia5, Etha, dia0, LBGexp, M0t45, Lbexp, Diami, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S110" promotor_-10 319754..319773 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 319754 /Source="Nicolas_upshifts" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(319850) /Source="Nicolas_upshifts" /id="D136" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="1.2989" /MaxDrop="4.67402" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS 319855..320673 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /EC_number="6.3.1.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7890752, 9271869, 12682299, 19204287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7890752, 9271869, 12682299, 19204287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ammonium-dependent NAD+ synthetase" /protein_id="NP_388195.1" /db_xref="EnsemblGenomes-Gn:BSU03130" /db_xref="EnsemblGenomes-Tr:CAB12107" /db_xref="GOA:P08164" /db_xref="InterPro:IPR003694" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022926" /db_xref="PDB:1EE1" /db_xref="PDB:1FYD" /db_xref="PDB:1IFX" /db_xref="PDB:1IH8" /db_xref="PDB:1KQP" /db_xref="PDB:1NSY" /db_xref="PDB:2NSY" /db_xref="SubtiList:BG10694" /db_xref="UniProtKB/Swiss-Prot:P08164" /translation="MSMQEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVL GISGGQDSTLAGRLAQLAVESIREEGGDAQFIAVRLPHGTQQDEDDAQLALKFIKPDK SWKFDIKSTVSAFSDQYQQETGDQLTDFNKGNVKARTRMIAQYAIGGQEGLLVLGTDH AAEAVTGFFTKYGDGGADLLPLTGLTKRQGRTLLKELGAPERLYLKEPTADLLDEKPQ QSDETELGISYDEIDDYLEGKEVSAKVSEALEKRYSMTEHKRQVPASMFDDWWK*" /label="nadE CDS" gene 319855..320673 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /label="nadE gene" downshifts 320655 /Source="Nicolas_upshifts" /id="D137" /incds=0 /nref=144 /ntot=271 /MaxReadThrough="2.68866" /MaxDrop="6.24927" /score="20.6612287" /energy="-14.1" /TU="U230" /idTUdmin="U230" /TUdmin="-65" /isTUend="FALSE" /label="downshifts" CDS complement(320723..321316) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1624425, 7766032, 15131133, 27315722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624425, 7766032, 15131133, 27315722; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATP-binding tunicamycin resistance protein" /protein_id="NP_388196.2" /db_xref="EnsemblGenomes-Gn:BSU03140" /db_xref="EnsemblGenomes-Tr:CAB12108" /db_xref="GOA:P12921" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10456" /db_xref="UniProtKB/Swiss-Prot:P12921" /translation="MIIWINGAFGSGKTQTAFELHRRLNPSYVYDPEKMGFALRSMVP QEIAKDDFQSYPLWRAFNYSLLASLTDTYRGILIVPMTIVHPEYFNEIIGRLRQEGRI VHHFTLMASKETLLKRLRTRAEGKNSWAAKQIDRCVEGLSSPIFEDHIQTDNLSIQDV AENIAARAELPLDPDTRGSLRRFADRLMVKLNHIRIK*" /label="tmrB CDS" gene complement(320723..321316) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /label="tmrB gene" downshifts complement(320730) /Source="Nicolas_upshifts" /id="D138" /incds=0 /nref=10 /ntot=143 /MaxReadThrough="0.60282" /MaxDrop="3.74815" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(321331..321350) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(321346) /Source="Nicolas_upshifts" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(321365..321368) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(321374..321522) /Source="Nicolas_S_feature" /locus_tag="new_339807_339955_c" /HighExp="S4, S3, S6, S5, S7, BT, S8, LoTm, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S111" promotor_-35 321424..321431 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 321444..321463 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 321446..321554 /Source="Nicolas_S_feature" /locus_tag="new_339879_339987" /HighExp="Diami, BMM, GM 15, GM 25, GM 120, GM 60, GM 10, G180, GM 45, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S112" upshifts 321448 /Source="Nicolas_upshifts" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(321516..321534) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 321522..321529 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(321532) /Source="Nicolas_upshifts" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 321544..321563 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(321550..321555) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 321556 /Source="Nicolas_upshifts" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="upshifts" CDS 321592..322152 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /EC_number="2.7.1.71" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 170268, 7612934, 27339308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate kinase" /protein_id="NP_388197.2" /db_xref="EnsemblGenomes-Gn:BSU03150" /db_xref="EnsemblGenomes-Tr:CAB12109" /db_xref="GOA:P37944" /db_xref="InterPro:IPR000623" /db_xref="InterPro:IPR023000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031322" /db_xref="SubtiList:BG10457" /db_xref="UniProtKB/Swiss-Prot:P37944" /translation="MNAKRAIPVRERNIVLIGFMGVGKTTIGQLVAKKLYRDFIDIDQ QIEKDFNMSIPEIFEKKGEDFFRKTEKEYILDICHHKRFKIVSLGGGSFKQEEIRNCC LENCLVLHLDLSWENWKQRADLLIESRPVLHNRSMDEMEQLFNERKVIYDKHNSKVAT DNLSPEEVADYIVETLKIGWDLYQPM*" /label="aroK CDS" gene 321592..322152 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /label="aroK gene" downshifts 322129 /Source="Nicolas_upshifts" /id="D139" /incds=0 /nref=21 /ntot=239 /MaxReadThrough="2.07607" /MaxDrop="4.67156" /score="44.9099474" /energy="-13.1" /TU="NA" /idTUdmin="U232" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(322180..322941) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388198.2" /db_xref="EnsemblGenomes-Gn:BSU03160" /db_xref="EnsemblGenomes-Tr:CAB12110" /db_xref="GOA:O31474" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XXL" /db_xref="PDB:2GLU" /db_xref="SubtiList:BG12008" /db_xref="UniProtKB/Swiss-Prot:O31474" /translation="MTNETPFSKNAEMYRDEKVFAEGEDLGLMIKTAECRAEHRVLDI GAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAESLPFPDD SFDIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEFVNHLNRLR DPSHVRESSLSEWQAMFSANQLAYQDIQKWNLPIQYDSWIKRGGTPADREKQIITHLN HASDEARDTFCITLNQNGQPISFCLKAILIQGIKR*" /label="ycgJ CDS" gene complement(322180..322941) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /label="ycgJ gene" downshifts complement(322204) /Source="Nicolas_upshifts" /id="D140" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.31391" /MaxDrop="3.85249" /score="18.9843263" /energy="-13.1" /TU="NA" /idTUdmin="U235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(322973..322992) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 322974..322981 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(322979) /Source="Nicolas_upshifts" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 322996..323015 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(323007..323012) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 323008 /Source="Nicolas_upshifts" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" CDS 323059..324033 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_388199.2" /db_xref="EnsemblGenomes-Gn:BSU03170" /db_xref="EnsemblGenomes-Tr:CAB12111" /db_xref="GOA:P94387" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12009" /db_xref="UniProtKB/Swiss-Prot:P94387" /translation="MDIKVMEYAAEIARRQSFTKAAEHLHIAQPSLSQQIKKLEAELG LTLFHRSHGSVTLTPHGRRFIEKAEDIIRSRDDLLREMQERSQGIGHKLSIGIPAVTG RYLFPPLLKQFLARYPHVEVQLVEKDPVSLEKMTAKGEVDLSVLSLPIEDERLSITPL LTEPVVLAVPKEKQRWMPPELVALIEKALEEDEGRQPCVPIDMVRNVPFILLKEGFGF RRTVLDLCAESGFKPNAAFKTSHIETAQSLVANGLGVTMAPNMVRRDKDPGVIYLSIQ SAPSRTLVFVFLKNRYVSLTAQAFMELSRESLKQTFDEGCLGNKDENI*" /label="ycgK CDS" gene 323059..324033 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /label="ycgK gene" S_feature 324034..324104 /Source="Nicolas_S_feature" /locus_tag="new_342467_342537" /HighExp="Diami, dia5, dia15, S1, dia0, C90, LBGexp, Heat, Lbexp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S113" CDS 324105..325061 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /EC_number="3.1.1.41" /EC_number="3.1.1.72" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12842474, 19837798, 21382014" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12842474, 19837798, 21382014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acetyl xylan esterase-cephalosporin C deacetylase" /protein_id="NP_388200.1" /db_xref="EnsemblGenomes-Gn:BSU03180" /db_xref="EnsemblGenomes-Tr:CAB12112" /db_xref="GOA:P94388" /db_xref="InterPro:IPR008391" /db_xref="InterPro:IPR029058" /db_xref="PDB:1L7A" /db_xref="PDB:1ODS" /db_xref="PDB:1ODT" /db_xref="SubtiList:BG11919" /db_xref="UniProtKB/Swiss-Prot:P94388" /translation="MQLFDLPLDQLQTYKPEKTAPKDFSEFWKLSLEELAKVQAEPDL QPVDYPADGVKVYRLTYKSFGNARITGWYAVPDKEGPHPAIVKYHGYNASYDGEIHEM VNWALHGYATFGMLVRGQQSSEDTSISPHGHALGWMTKGILDKDTYYYRGVYLDAVRA LEVISSFDEVDETRIGVTGGSQGGGLTIAAAALSDIPKAAVADYPYLSNFERAIDVAL EQPYLEINSFFRRNGSPETEVQAMKTLSYFDIMNLADRVKVPVLMSIGLIDKVTPPST VFAAYNHLETKKELKVYRYFGHEYIPAFQTEKLAFFKQHLKG*" /label="cah CDS" gene 324105..325061 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /label="cah gene" promotor_-35 324520..324526 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 324541..324552 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 324548 /Source="Nicolas_upshifts" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" S_feature 325062..325140 /Source="Nicolas_S_feature" /locus_tag="new_343495_343573" /HighExp="dia5, dia15, Diami, dia0, B36, S1, MG 10, BT, B60, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S114" promotor_-35 325115..325120 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 325137..325155 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 325142 /Source="Nicolas_upshifts" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" CDS 325145..325927 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388201.1" /db_xref="EnsemblGenomes-Gn:BSU03190" /db_xref="EnsemblGenomes-Tr:CAB12113" /db_xref="InterPro:IPR018775" /db_xref="SubtiList:BG12010" /db_xref="UniProtKB/Swiss-Prot:P94389" /translation="MKQRIIDELKRIEQSYGVKIVYAVESGSRAWGFPSQDSDYDVRF IYVPKKEWYFSIEQERDVIEEPIHDLLDISGWELRKTLRLFKKSNPPLLEWLSSDIVY YEAFTTAEQLRKLRTEAFKPEASVYHYINMARRNVKDYLQGQEVKIKKYFYVLRPILA CQWIEKHGTIPPMDFTVLMNELVAEPELKAEMETLLERKRRGEELDLEARIDVIHQFI ETEIERIMEAAKELKAEKKDMTSELNRLLLNTVEEVWKDGGS*" /label="ycgL CDS" gene 325145..325927 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /label="ycgL gene" downshifts 325892 /Source="Nicolas_upshifts" /id="D141" /incds=0 /nref=11 /ntot=63 /MaxReadThrough="3.94077" /MaxDrop="4.37398" /score="0.421649027" /energy="-5.9" /TU="U238" /idTUdmin="U236" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 325937..326064 /Source="Nicolas_S_feature" /locus_tag="new_344370_344497" /HighExp="S5, S6, S8, S4, S7, B36, B60, BT, S3, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S115" promotor_-35 326041..326045 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 326060..326079 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 326066 /Source="Nicolas_upshifts" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 326118..327029 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /EC_number="1.5.5.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17536821, 2118500, 21840319, 22139509, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17536821, 2118500, 21840319, 22139509, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline oxidase" /protein_id="NP_388202.1" /db_xref="EnsemblGenomes-Gn:BSU03200" /db_xref="EnsemblGenomes-Tr:CAB12114" /db_xref="GOA:P94390" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG12011" /db_xref="UniProtKB/Swiss-Prot:P94390" /translation="MITRDFFLFLSKSGFLNKMARNWGSRVAAGKIIGGNDFNSSIPT IRQLNSQGLSVTVDHLGEFVNSAEVARERTEECIQTIATIADQELNSHVSLKMTSLGL DIDMDLVYENMTKILQTAEKHKIMVTIDMEDEVRCQKTLDIFKDFRKKYEHVSTVLQA YLYRTEKDIDDLDSLNPFLRLVKGAYKESEKVAFPEKSDVDENYKKIIRKQLLNGHYT AIATHDDKMIDFTKQLAKEHGIANDKFEFQMLYGMRSQTQLSLVKEGYNMRVYLPYGE DWYGYFMRRLAERPSNIAFAFKGMTKK*" /label="putB CDS" gene 326118..327029 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /label="putB gene" CDS 327046..328593 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 17183215, 21840319, 22139509, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 17183215, 21840319, 22139509, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-pyrroline-5-carboxylate dehydrogenase" /protein_id="NP_388203.2" /db_xref="EnsemblGenomes-Gn:BSU03210" /db_xref="EnsemblGenomes-Tr:CAB12115" /db_xref="GOA:P94391" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12012" /db_xref="UniProtKB/Swiss-Prot:P94391" /translation="MTTPYKHEPFTNFQDQNNVEAFKKALATVSEYLGKDYPLVINGE RVETEAKIVSINPADKEEVVGRVSKASQEHAEQAIQAAAKAFEEWRYTSPEERAAVLF RAAAKVRRRKHEFSALLVKEAGKPWNEADADTAEAIDFMEYYARQMIELAKGKPVNSR EGEKNQYVYTPTGVTVVIPPWNFLFAIMAGTTVAPIVTGNTVVLKPASATPVIAAKFV EVLEESGLPKGVVNFVPGSGAEVGDYLVDHPKTSLITFTGSREVGTRIFERAAKVQPG QQHLKRVIAEMGGKDTVVVDEDADIELAAQSIFTSAFGFAGQKCSAGSRAVVHEKVYD QVLERVIEITESKVTAKPDSADVYMGPVIDQGSYDKIMSYIEIGKQEGRLVSGGTGDD SKGYFIKPTIFADLDPKARLMQEEIFGPVVAFCKVSDFDEALEVANNTEYGLTGAVIT NNRKHIERAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQA KTISEMF*" /label="putC CDS" gene 327046..328593 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /label="putC gene" promotor_-35 328017..328023 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328037..328056 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328045 /Source="Nicolas_upshifts" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 328128..328134 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328147..328166 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328156 /Source="Nicolas_upshifts" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" misc_feature 328592..328596 /Source="Nicolas_upshift_promotors" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 328594..328716 /Source="Nicolas_S_feature" /locus_tag="new_347027_347149" /HighExp="S1, T2.0H, T2.30H, Lbstat, aero, HiOs, BC, Sw, LPh, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52312199999999998" /TUshortSig="Sig-, SigA, SigA, SigA, SigEF" /TUshortPSig="0.249, 1, 0.994, 0.922, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S116" upshifts 328596 /Source="Nicolas_upshifts" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 328717..330138 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline permease" /protein_id="NP_388204.2" /db_xref="EnsemblGenomes-Gn:BSU03220" /db_xref="EnsemblGenomes-Tr:CAB12116" /db_xref="GOA:P94392" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12013" /db_xref="UniProtKB/Swiss-Prot:P94392" /translation="MLLIGYFAYKRTSNLTDYMLGGRSLGPAVTALSAGAADMSGWLL MGLPGAMFSTGLSGAWIVIGLCLGAWANWLYVAPRLRTYTEKAGNSITIPGFLENRFG DQTKLLRLFSGIVILVFFTFYVSSGMVSGGVLFNSILGMDYHTGLWIVTGVVVAYTLF GGFLAVSWTDFVQGIIMFAALILVPIVTFFHTGGAGDTVAEIRSVDPDMFNIFKGTSV LGIISLFAWGLGYFGQPHIIVRFMAITSVKEIKRARRIGMGWMILSAVGAVLTGLGGI AYYHQRGMTLKDPETIFIQLGNILFHPIITGFLISAILAAIMSTISSQLLVTSSSLVE DLYKSMFRRSASDKELVFLGRLAVLAVSIVALVLAWEKNNTILGLVSYAWAGFGASFG PVVLLSLFWKRMTKWGALAGMIVGAATVIIWANAGLSDFLYEMIPGFAASLLSVFFVS ILTQAPSQAVTDQFNDYQDTMSQ*" /label="putP CDS" gene 328717..330138 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /label="putP gene" S_feature complement(329237..331092) /Source="Nicolas_S_feature" /locus_tag="new_347670_349525_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, C30, T4.0H, Lbstat" /AntisenseName="ycgP" /AntisenseCor="0.143781082577395" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.679" /TUlongSig="NA" /TUlongPSig="NA" /label="S117" downshifts 330118 /Source="Nicolas_upshifts" /id="D142" /incds=0 /nref=21 /ntot=160 /MaxReadThrough="5.09597" /MaxDrop="4.17771" /score="5.89792272" /energy="-15.9" /TU="U239,U240,U242" /idTUdmin="U238" /TUdmin=4 /isTUend="TRUE" /label="downshifts" S_feature 330163..330259 /Source="Nicolas_S_feature" /locus_tag="new_348596_348692" /HighExp="S1, LPh, T2.0H, HPh, aero, Lbstat, LoTm, T2.30H, Cold, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.249, 0.994, 0.922" /TUlongSig="NA" /TUlongPSig="NA" /label="S118" promotor_-35 330230..330237 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 330252..330271 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 330261 /Source="Nicolas_upshifts" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 330291..331526 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21840319, 21964733, 22139509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21840319, 21964733, 22139509; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of proline degradationoperon" /protein_id="NP_388205.2" /db_xref="EnsemblGenomes-Gn:BSU03230" /db_xref="EnsemblGenomes-Tr:CAB12117" /db_xref="GOA:P94393" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12014" /db_xref="UniProtKB/Swiss-Prot:P94393" /translation="MEELLERVFSFSDVDKLIDFISYELQKPVILESADFFLLAYNSY YINHFDSANQQTIFSKKCPVQIFERFLKDGIIEKLKTEPEPFRVNKIESIGLNQRVVV SAKHKGEVMGYIWIQELDQNLTDEELDFLYETSFHVGKIIYKTNKLKQEKEEKAEDLI KRAIYQQFTSEKELRREAERINTVLPSMFSVVILHAANGDGEAVEDLKENIRSYLNLR DKVSHVLTIESNIVIVVASFSQKSSVSSAASEFINKLLTHFHFQKIPTPIYIGIGNEY NHLLKLGKSYTEALEVIKAAEITGNQENIPYEYAKLGIYRYLESIEQKNEFLEYENKD LALLKAKDEESSTELLKTLEIYLLNNCKTKPAAEQLFIHQNTLNYRIKQITEMTSIDL SDFRTRCQLYLDLMLMKKK*" /label="putR CDS" gene 330291..331526 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /label="putR gene" promotor_-10 complement(331085..331103) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(331102) /Source="Nicolas_upshifts" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(331117..331124) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(331510) /Source="Nicolas_upshifts" /id="D143" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="0.0291099999999993" /MaxDrop="3.08474" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=66 /isTUend="FALSE" /label="downshifts" CDS complement(331563..332420) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388206.1" /db_xref="EnsemblGenomes-Gn:BSU03240" /db_xref="EnsemblGenomes-Tr:CAB12118" /db_xref="GOA:P94394" /db_xref="InterPro:IPR015402" /db_xref="SubtiList:BG12015" /db_xref="UniProtKB/Swiss-Prot:P94394" /translation="MFRLLVLMGFTFFFYHLHASGNLTKYINMKYAYLSFIAIFLLAI LTAVQAYLFIKSPEKSGHHHDHDCGCGHDHEHDHEQNKPFYQRYLIYVVFLFPLVSGI FFPIATLDSSIVKTKGFSFKAMESGDHYSQTQYLRPDASLYYAQDSYDKQMKQLFNKY SSKKEISLTDDDFLKGMETIYNYPGEFLGRTIEFHGFAYKGNAINKNQLFVLRFGIIH CIADSGVYGMLVEFPKDMDIKDDEWIHIKGTLASEYYQPFKSTLPVVKVTDWNTIKKP DDPYVYRGF*" /label="ycgQ CDS" gene complement(331563..332420) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /label="ycgQ gene" downshifts complement(331576) /Source="Nicolas_upshifts" /id="D144" /incds=0 /nref=48 /ntot=167 /MaxReadThrough="1.97725" /MaxDrop="4.53007" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(332425..333309) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388207.1" /db_xref="EnsemblGenomes-Gn:BSU03250" /db_xref="EnsemblGenomes-Tr:CAB12119" /db_xref="GOA:P94395" /db_xref="InterPro:IPR005524" /db_xref="SubtiList:BG12016" /db_xref="UniProtKB/Swiss-Prot:P94395" /translation="MTAQSSFLQLNSIFISILIEAIPFILIGVILSGIIQMFVSEEMI ARIMPKNRFLAVLFGALAGVLFPACECGIIPITRRLLLKGVPLHAGVAFMLTAPIINP IVLFSTYIAFGNRWSVVFYRGGLALAVSLIIGVILSYQFKDNQLLKPDEPGHHHHHHG TLLQKLGGTLRHAIDEFFSVGKYLIIGAFIAAAMQTYVKTSTLLAIGQNDVSSSLVMM GLAFVLSLCSEVDAFIASSFSSTFSLGSLIAFLVFGAMVDIKNLLMMLAAFKKRFVFL LITYIVVIVLAGSLLVKG*" /label="ycgR CDS" gene complement(332425..333309) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /label="ycgR gene" upshifts complement(333361) /Source="Nicolas_upshifts" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(333366..333379) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(333394..333402) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(333409..334263) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /EC_number="3.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic hydrocarbon hydrolase" /protein_id="NP_388208.1" /db_xref="EnsemblGenomes-Gn:BSU03260" /db_xref="EnsemblGenomes-Tr:CAB12120" /db_xref="GOA:P94396" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12017" /db_xref="UniProtKB/Swiss-Prot:P94396" /translation="MKRRVETITFDGGTLEYSVTGKGTPILVMHGGHSNCYEEFGYTA LIEQGYSIITPSRPGYGRTSKEIGKSLANACRFYVKLLDHLQIESVHVIAISAGGPSG ICFASHYPERVNTLTLQSAVTKEWLTPKDTEYKLGEILFRPPVEKWIWKLISSLNNAF PRLMFRAMSPQFSTLPFQRIKSLMNEKDIEAFRKMNSRQRSGEGFLIDLSQTAAVSLK DLQAIICPVLIMQSVYDGLVDLSHAHHAKEHIRGAVLCLLHSWGHLIWLGKEAAETGS ILLGFLES*" /label="ycgS CDS" gene complement(333409..334263) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /label="ycgS gene" promotor_-10 complement(334282..334301) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-10" upshifts complement(334302) /Source="Nicolas_upshifts" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="upshifts" promotor_-35 complement(334316..334319) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-35" misc_feature 334353..334372 /Source="Nicolas_upshift_promotors" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(334353..334371) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 334360..334424 /Source="Nicolas_S_feature" /locus_tag="new_352793_352857" /HighExp="B60, Lbexp, LBGexp, dia0, B36, HiOs, GM 15, GM 10, Salt, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S119" upshifts 334361 /Source="Nicolas_upshifts" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(334370) /Source="Nicolas_upshifts" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(334387..334392) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 334425..335435 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /EC_number="1.18.1.-" /EC_number="1.8.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16672620, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 25826316; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Fur-regulated NADPH:ferredoxin oxidoreductase" /protein_id="NP_388209.1" /db_xref="EnsemblGenomes-Gn:BSU03270" /db_xref="EnsemblGenomes-Tr:CAB12121" /db_xref="GOA:O31475" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12018" /db_xref="UniProtKB/Swiss-Prot:O31475" /translation="MAENQEVYDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGG KVSLFFPEKIIRDIGGIPGIAGKQLIEQLKEQAATFDPDIVLNQRVTGFERLDDGTIV LTGSEGKKHYTRTVILACGMGTLEVNEFDSEDAARYAGKNLHYGVEKLDAFKGKRVVI SGGGDTAVDWANELEPIAASVTVVHRREEFGGMESSVTKMKQSSVRVLTPYRLEQLNG DEEGIKSVTVCHTESGQRKDIEIDELIINHGFKIDLGPMMEWGLEIEEGRVKADRHMR TNLPGVFVAGDAAFYESKLRLIAGGFTEGPTAVNSAKAYLDPKAENMAMYSTHHKKLV HK*" /label="ffoR CDS" gene 334425..335435 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /label="ffoR gene" S_feature 335436..337883 /Source="Nicolas_S_feature" /locus_tag="new_353869_356316" /HighExp="B60, Lbexp, GM 10, GM 25, HiOs, GM 15, dia0, GM 45, LBGexp, H2O2" /AntisenseName="nasF" /AntisenseCor="-0.30348565853404702" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S120" CDS complement(335467..336918) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /EC_number="2.1.1.107" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9765565, 10217486, 15028686" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765565, 10217486, 15028686; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrin-III C-methyltransferase" /protein_id="NP_388210.1" /db_xref="EnsemblGenomes-Gn:BSU03280" /db_xref="EnsemblGenomes-Tr:CAB12122" /db_xref="GOA:P42437" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR012409" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG11098" /db_xref="UniProtKB/Swiss-Prot:P42437" /translation="MIMKNGIVYFVGAGPGDPGLLTIKGKQALKEADVILYDRLANPK LLEFASPDCQFIYCGKLPNRHFMKQKEINALLVEKALNGLTVVRLKGGDPSVFGRVGE EADALHEHGIRYEMVPGITSGIAAPLYAGIPVTHRDFASSFAMITAHDKSLKGTPNLD WEGLARSVQTLVFYMGVKNLSYICQQLISYGKSPSVPVIVIQWGTWGRQRSVKGTLEN IQQKVQEHQITNPAIIVIGDIVNFQTHSWFESKPLIGRHLMVVTHGEDEDPLADKLRD SGADLIEWPKWRTENMPVNEEILRKIGTFEDVFFTSRRAVCEFFRALASQKIDIRQLT AKLSAASEQAKTELEKRGFLVTAIQPDSEKRLVVGSRHAVENMQKHESCSFYITHENV IDDRFTHMIQRTISESPLHMVICPNKLSVQQLINGGEQIGILPEPSASRPPIVCIGDD SAAGIYGFTAVQEQDELLAFIHNQHAEKKLLHT*" /label="nasF CDS" gene complement(335467..336918) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /label="nasF gene" downshifts complement(335471) /Source="Nicolas_upshifts" /id="D145" /incds=0 /nref=131 /ntot=230 /MaxReadThrough="1.40657" /MaxDrop="6.58881" /score="10.9556399" /energy="-11.7" /TU="NA" /idTUdmin="U250" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(336979..337299) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 15028686, 9765565, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 15028686, 9765565, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388211.1" /db_xref="EnsemblGenomes-Gn:BSU03290" /db_xref="EnsemblGenomes-Tr:CAB12123" /db_xref="GOA:P42436" /db_xref="InterPro:IPR012748" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11097" /db_xref="UniProtKB/Swiss-Prot:P42436" /translation="MVNKDVTKVCIGKIEELPEQLGKTVYIEDKELAVFKLSDGSIRA IENRCPHKGGVLAEGIVSGQYVFCPMHDWKISLEDGIVQEPDHGCVKTYETLIEGEHV YLVY*" /label="nasE CDS" gene complement(336979..337299) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /label="nasE gene" promotor_-35 337150..337155 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 337169..337173 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 337176 /Source="Nicolas_upshifts" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(337208) /Source="Nicolas_upshifts" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(337210..337229) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(337243..337250) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(337331..339748) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565, 16428414, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565, 16428414, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388212.1" /db_xref="EnsemblGenomes-Gn:BSU03300" /db_xref="EnsemblGenomes-Tr:CAB12124" /db_xref="GOA:P42435" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11096" /db_xref="UniProtKB/Swiss-Prot:P42435" /translation="MGKKQLVLVGNGMAGVRAIEEILSVAKDEFQITIFGAEPHPNYN RILLSKVLQGDTDIKDITLNDWDWYEENNIQLYTNETVIKVDTENKTVITDADRIQPY DELILATGSVPFILPIPGADKKGVTAFRDIKDTDTMLAASKQYKKAAVIGGGLLGLEA ARGLLNLGMDVSVIHLAPFLMERQLDATAGRLLQNELEKQGMTFLLEKQTEEIVGDDR VEGLRFKDGTSIEADLVVMAVGIRPNTTLGAESGIPVNRGIIVNDYMQTEIPHIYAVG ECAEHRGIAYGLVAPLYEQAKVLAKHMCGIETKPYEGSVLSTQLKVSGVEVFSAGDFN ESEEKKAIKVFDEQDGIYKKIVLRGNQIVGAVLFGDSSEGNRLFSMIQKEADISETSK ISILQPLSQEAGTSITAAMSDDEIICGCNGVSKGAIIQAIQEKGCSSTDEIKACTGAS RSCGGCKPLVEEILQHTLGSDFDASAQKEAICGCTTLSRDEVVEEIKAKGLSHTREVM NVLGWKTPEGCSKCRPALNYYLGMINPTKYEDDRTSRFVNERMHANIQKDGTYSVVPR MYGGVTNSTDLRKIADVVDKYEIPLVKMTGGQRIDLIGVKKEDLPKVWEDLDMPSGYA YGKTLRTVKTCVGEQFCRFGTQDSMALGIALEKKFEGLNTPHKVKMAVSACPRNCAES GIKDLGVVGIDGGWELYVGGNGGTHLRAGDLLMKVKTNEEVLEYAGAYLQYYRETANY LERTSAWLERVGLSHVQSVLNDPEKRQELNGRMNETLSVHKDPWKDFLEDKQTSKELF ENVVTTS*" /label="nasD CDS" gene complement(337331..339748) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /label="nasD gene" promotor_-10 complement(339773..339792) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(339787) /Source="Nicolas_upshifts" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(339804..339810) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(339870..342002) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /EC_number="1.7.99.4" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (catalytic subunit)" /protein_id="NP_388213.2" /db_xref="EnsemblGenomes-Gn:BSU03310" /db_xref="EnsemblGenomes-Tr:CAB12125" /db_xref="GOA:P42434" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="SubtiList:BG11095" /db_xref="UniProtKB/Swiss-Prot:P42434" /translation="MTERLLRYFRDKQQDVQSEKTYDTQCPFCSMQCKMQLVEQTIVT RKKYTAIGIDNPTTQGRLCIKGMNAHQHALNSSRITRPLLKKNGEFMPVSWEEALNHI KDQVTMIQTEHGHDAMAVYGSASITNEEAYLLGKFARVGLQTKYIDYNGRLCMSAAAT AANQTFGADRGLTNPLSDIPHTRVIILAGTNIAECQPTIMPYFEKAKENGAYFIAIDP RETATTKIADLHLKIKPGTDAALANGLVKIIIDEQLINEDFIQSRTNGFEELKQHTDS LDLNDIAEQTSVSLVDIRKAAVKFAKETSGMLFTARGIEQQTDGTAAVKGFLNMVLIT GKIGKPYSGYGAITGQGNGQGAREHGQKADQLPGYRSIENEEHRAHIAKVWGIHQDEL PRKGVSAYEMMEKINDGDIKGLFLMCSNPAVSSPNANLVKKALRRLTFFVAIDLFISE TAKYADVILPASSYLEDEGTMTNVEGRVTLREASRPCPGEAKHDWQIICDLASALGKG RYFSYTSAEDIFNELREASRGGIADYSGISYGRLRREGGIHWPCPESDHPGTGRLFTE SFAHPDQKAALSVIPNEPPVPKEKPTADYPLYLTTGRVMSHYLTGVQTRKSAALAARH FESFMEIHPQTAATYNIEDRVLVKIESPRGSITVRSKLSEQIRKDTVFVPIHWADAQN VNDLIGEALDPACKMPGFKVCAVRIIPI*" /label="nasC CDS" gene complement(339870..342002) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /label="nasC gene" CDS complement(342009..344324) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /EC_number="1.7.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (electron transfer subunit NasB)" /protein_id="NP_388214.2" /db_xref="EnsemblGenomes-Gn:BSU03320" /db_xref="EnsemblGenomes-Tr:CAB12126" /db_xref="GOA:P42433" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11094" /db_xref="UniProtKB/Swiss-Prot:P42433" /translation="MKKQRLVLAGNGMAGIRCIEEVLKLNRHMFEIVIFGSEPHPNYN RILLSSVLQGEASLDDITLNSKDWYDKHGITLYTGETVIQIDTDQQQVITDRKRTLSY DKLIVATGSSPHILPIPGADKKGVYGFRTIEDCQALMNMAQHFQKAAVIGAGLLGLEA AVGLQHLGMDVSVIHHSAGIMQKQLDQTAARLLQTELEQKGLTFLLEKDTVSISGATK ADRIHFKDGSSLKADLIVMAAGVKPNIELAVSAGIKVNRGIIVNDFMQTSEPNIYAVG ECAEHNGTVYGLVAPLYEQGKALASHICGVPCEEYQGSAPSAALKIAGIDVWSAGKIQ EDERTTSIKIYDEQAGVYKKALFVDDKLAGVILFGDTRDKQRLLDSLLKQRDISIAKK QIIEPETSGPLFESMPSSETICQCNTVTKGAIEDAVHTNSLTTVEEVKHCTKATGSCG GCKPLVEDLLRYMTNSEYTKPASTPSFCSCTDFTEDDIIAELQRRPFTNPAEVMNQLD WKTKNGCSTCVPAIQYYLEMLYPGFVQPEPATEETCILIPQMYGGRTNAEQLRTIANI IEAYSIPDVSITHGQRLKLSGIKPADLPNMKKDLKMPVYTNEHRHALQSIKACTCGQN RSIQQLAAQIERQLEMLPLPAPISISLSCETDCTEAALQDVGAIRTQAGWDIHIGGVR GTHARSGALFCVTENEDSTAGMIKGLIQYYRETAHYLEGVHQWIDRLGIVHIREVLFE EDLRAQLLESLQTDLSLIQNPTVETGAYKKG*" /label="nasB CDS" gene complement(342009..344324) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /label="nasB gene" promotor_no_box complement(344343..344443) /Source="Nicolas_upshift_promotors" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(344383) /Source="Nicolas_upshifts" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 344426..344433 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 344447..344466 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 344459 /Source="Nicolas_upshifts" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="upshifts" CDS 344504..345709 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7868621, 12823818, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative nitrate transporter" /protein_id="NP_388215.2" /db_xref="EnsemblGenomes-Gn:BSU03330" /db_xref="EnsemblGenomes-Tr:CAB12127" /db_xref="GOA:P42432" /db_xref="InterPro:IPR004737" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11093" /db_xref="UniProtKB/Swiss-Prot:P42432" /translation="MKLSELKTSGHPLTLLCSFLYFDVSFMIWVMLGALGVYISQDFG LSPFEKGLVVAVPILSGSVFRIILGILTDRIGPKKTAVIGMLVTMIPLLWGTFGGRSL TELYAIGILLGVAGASFAVALPMASRWYPPHLQGLAMGIAGAGNSGTLFATLFGPRLA EQFGWHIVMGIALIPLLIVFILFVSMAKDSPAQPSPQPLKSYLHVFGQKETWFFCLLY SVTFGGFVGLSSFLSIFFVDQYQLSKIHAGDFVTLCVAAGSFFRPVGGLISDRVGGTK VLSVLFVIVALCMAGVSSLPSLSMVIVLLFVGMMGLGMGNGAVFQLVPQRFRKEIGMV TGIVGAAGGIGGFFLPNILGSLKQMTGTYAIGFITFSCIALLAFALVLAAGYYWRKSW SAESSPADV*" /label="nasA CDS" gene 344504..345709 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /label="nasA gene" downshifts 345694 /Source="Nicolas_upshifts" /id="D146" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.02479" /MaxDrop="3.6823" /score="39.2612286" /energy="-11.9" /TU="NA" /idTUdmin="U253" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 345753..345759 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-35" promotor_-10 345774..345793 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-10" upshifts 345782 /Source="Nicolas_upshifts" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="upshifts" CDS 345826..346740 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12426338, 17032654, 19767425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12426338, 17032654, 19767425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_388216.2" /db_xref="EnsemblGenomes-Gn:BSU03340" /db_xref="EnsemblGenomes-Tr:CAB12128" /db_xref="GOA:P94398" /db_xref="InterPro:IPR003801" /db_xref="InterPro:IPR022838" /db_xref="SubtiList:BG12019" /db_xref="UniProtKB/Swiss-Prot:P94398" /translation="MNQHTLLPKKTERLQYFGSVSPIKGEKPVEKEKMKDLQNIRKDY FFDIQHVGVANVSHPVTITSAMMPAEQTTAANFTMTCNLPRNQKGINMSRLTELLQVY HQNGWILSFSSLQQFTKELAENMDTSSATVEVRFPWFFERKSPKLEKAGLMHADIFMS VTYRKDQPFKQRAGISAKVTTLCPCSKEISEYSAHNQRGTVSIWADIHPAASLPSDVK ADLLHAAESNASARLHPVLKRPDEKAVTETAYENPRFVEDLARLIAADLFELEWVSAF EIECRNEESIHLHDAYAKLCFSKEVDKI*" /label="folEB CDS" gene 345826..346740 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /label="folEB gene" CDS 346737..347321 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12426338, 20013255; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative Zn(2+)-dependent division lipoprotein (schizosome)" /protein_id="NP_388217.2" /db_xref="EnsemblGenomes-Gn:BSU03350" /db_xref="EnsemblGenomes-Tr:CAB12129" /db_xref="GOA:C0SP99" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG12020" /db_xref="UniProtKB/Swiss-Prot:C0SP99" /translation="MKLSLFIIAVLMPVILLSACSDHAEEHASINTKKTVENITDVRK TAKTSIDWTKPSGGEYPDIKQKHVWIDVNVKEQKAYIKEGSNTIYTMMISSGLDQTKD DATPKGTFYVEPERGEWFFSEGYQEGAEYWVSWKNHGEFLFHSVPMTKDQKVIKTEAE KLGTKASHGCIRLTIPDAKWVYENIPEHTKVVIS*" /label="yciB CDS" gene 346737..347321 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /label="yciB gene" promotor_-35 347332..347339 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 347353..347372 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 347363 /Source="Nicolas_upshifts" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="upshifts" CDS 347417..347602 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097674.1" /db_xref="EnsemblGenomes-Gn:BSU03359" /db_xref="EnsemblGenomes-Tr:CAX52544" /db_xref="UniProtKB/Swiss-Prot:C0H3U7" /translation="MKSGKASIKDLAVGKGKDLRWGKGLNAVGVFTDLEIGRQREMSA KSCSTPLYIRRSIQFKS*" /label="yczL CDS" gene 347417..347602 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /label="yczL gene" CDS 347630..348823 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249; Product type t: transporter" /codon_start=1 /transl_table=11 /product="zinc metallochaperone with NTPase activity" /protein_id="NP_388218.1" /db_xref="EnsemblGenomes-Gn:BSU03360" /db_xref="EnsemblGenomes-Tr:CAB12130" /db_xref="GOA:P94400" /db_xref="InterPro:IPR003495" /db_xref="InterPro:IPR011629" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036627" /db_xref="SubtiList:BG12021" /db_xref="UniProtKB/Swiss-Prot:P94400" /translation="MKKIPVTVLSGYLGAGKTTLLNSILQNREGLKIAVIVNDMSEVN IDAGLVKQEGGLSRTDEKLVEMSNGCICCTLREDLLIEVEKLAKDGRFDYIVIESTGI SEPIPVAQTFSYIDEEMGIDLTKFCQLDTMVTVVDANRFWHDYQSGESLLDRKEALGE KDEREIADLLIDQIEFCDVLILNKCDLVSEQELEQLENVLRKLQPRARFIRSVKGNVK PQEILHTGLFNFEEASGSAGWIQELTAGHAEHTPETEEYGISSFVYKRRLPFHSTRFY RWLDQMPKNVVRAKGIVWCASHNNLALLMSQAGPSVTIEPVSYWVAALPKLEQEQVKQ QEPEILEEWDPEFGDRLTQLVFIGTDLDEETITKELDQCLLTEYEFDSDWSLFEDPFK WKLNQ*" /label="zinU CDS" gene 347630..348823 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /label="zinU gene" downshifts 348815 /Source="Nicolas_upshifts" /id="D147" /incds=0 /nref=26 /ntot=45 /MaxReadThrough="5.12378" /MaxDrop="5.8275" /score="15.6427627" /energy="-9.2" /TU="U255" /idTUdmin="U255" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" S_feature 348860..350529 /Source="Nicolas_S_feature" /locus_tag="new_367293_368962" /HighExp="Etha, B60, Cold, Heat, B36, C30, BMM, S6, C90, S2" /AntisenseName="yckB" /AntisenseCor="-0.170121935628575" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S121" CDS complement(348872..349552) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aminoacid ABC transporter (permease subunit)" /protein_id="NP_388219.1" /db_xref="EnsemblGenomes-Gn:BSU03370" /db_xref="EnsemblGenomes-Tr:CAB12131" /db_xref="GOA:P42399" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11177" /db_xref="UniProtKB/Swiss-Prot:P42399" /translation="MINSIQWEYIFNTKLAIESFPYVIKGIGYTLLISFVSMFAGTVI GLFISLARMSKLALLRWPAKLYISFMRGVPILVILFILYFGFPYIGIEFSAVTAALIG FSLNSAAYIAEINRSAISSVEKGQWEAASSLGLSYWQTMRGIILPQSIRIALPPLANV LLDLIKASSLAAMITVPELLQHAKIIGGREFDYMTMYILTALIYWAICSIAAVFQNIL EKKYAHYV*" /label="yckA CDS" gene complement(348872..349552) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /label="yckA gene" downshifts complement(348878) /Source="Nicolas_upshifts" /id="D148" /incds=0 /nref=101 /ntot=231 /MaxReadThrough="0.41655" /MaxDrop="6.18136" /score="40.1548023" /energy="-12.6" /TU="NA" /idTUdmin="U256" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(349562..350425) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23038252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="amino acid ABC transporter (binding lipoprotein subunit)" /protein_id="NP_388220.1" /db_xref="EnsemblGenomes-Gn:BSU03380" /db_xref="EnsemblGenomes-Tr:CAB12132" /db_xref="GOA:P42400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="PDB:2IEE" /db_xref="SubtiList:BG11178" /db_xref="UniProtKB/Swiss-Prot:P42400" /translation="MKSFMHSKAVIFSFTMAFFLILAACSGKNEADSKDTGWEQIKDK GKIVVATSGTLYPTSYHDTDSGSDKLTGYEVEVVREAAKRLGLKVEFKEMGIDGMLTA VNSGQVDAAANDIDVTKDREEKFAFSTPYKYSYGTAIVRKDDLSGIKTLKDLKGKKAA GAATTVYMEVARKYGAKEVIYDNATNEQYLKDVANGRTDVILNDYYLQTLALAAFPDL NITIHPDIKYMPNKQALVMKKSNAALQKKMNEALKEMSKDGSLTKLSKQFFNKADVSK KIDADVQDVDL*" /label="yckB CDS" gene complement(349562..350425) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /label="yckB gene" promotor_-10 complement(350447..350466) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(350459) /Source="Nicolas_upshifts" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(350461..353295) /Source="Nicolas_S_feature" /locus_tag="new_368894_371728_c" /HighExp="GM 150, T-4.40H, G/S, Pyr, S2, C30, T-5.40H, C90, T-3.40H, T0.30H" /AntisenseName="bglC" /AntisenseCor="-0.37749573319969598" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, Sig-" /TUshortPSig="0.248, 0.994, 0.0879" /TUlongSig="SigD" /TUlongPSig=1 /label="S122" promotor_-35 complement(350481..350488) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 350498..350504 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350519..350537 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 350531..350753 /Source="Nicolas_S_feature" /locus_tag="new_368964_369186" /HighExp="Etha, Salt, B60, Sw, B36, Gly, Heat, S6, Cold, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99896700000000005" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S123" upshifts 350531 /Source="Nicolas_upshifts" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 350587..350784 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513942.1" /translation="MSKDECQTYQGNACESEGCSRPVTHLCQYRKKWSRGMKPIFRIN LSLADAPKAYDIFDEKENGNI*" /label="hypothetical protein CDS" gene 350587..350784 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /label="gene" promotor_-35 350722..350727 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350743..350761 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 350755 /Source="Nicolas_upshifts" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 350803..351258 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral membrane protein of unknown function" /protein_id="NP_388221.1" /db_xref="EnsemblGenomes-Gn:BSU03390" /db_xref="EnsemblGenomes-Tr:CAB12133" /db_xref="GOA:P42401" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11179" /db_xref="UniProtKB/Swiss-Prot:P42401" /translation="MNIYKPAGFWIRLGAALLDYIIVSVPLLLIYWLITGKDPNDSMF ISLVVLLYSILLPMFWRGYLIGKRICGIRIVKKDGSQVSLLTMFLRVIVAGLVYCITF GLGLIASLILIAVREDKRTLHDLIAGTYVTYATPGEEELNADEEIRKSE*" /label="yckC CDS" gene 350803..351258 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /label="yckC gene" downshifts 351233 /Source="Nicolas_upshifts" /id="D149" /incds=0 /nref=40 /ntot=193 /MaxReadThrough="1.14817" /MaxDrop="5.48303" /score="23.1539807" /energy="-9.8" /TU="NA" /idTUdmin="U257" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 351281..351287 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 351294 /Source="Nicolas_upshifts" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 351301..351312 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 351340..351672 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388222.1" /db_xref="EnsemblGenomes-Gn:BSU03400" /db_xref="EnsemblGenomes-Tr:CAB12134" /db_xref="InterPro:IPR024485" /db_xref="SubtiList:BG11180" /db_xref="UniProtKB/Swiss-Prot:P42402" /translation="MKRITINIITMFIAAAVISLTGTAEAAEKQQQSPANVTLTDQQK KEIEQLEAEILKKRKDVISKYVQYGILPKERGEHIKNHLDKHFEMMKQNGFVPKHHPH PHKFEKRH*" /label="yckD CDS" gene 351340..351672 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /label="yckD gene" downshifts 351653 /Source="Nicolas_upshifts" /id="D150" /incds=0 /nref=20 /ntot=44 /MaxReadThrough="2.48743" /MaxDrop="4.3022" /score="-1.40416926" /energy="-11.8" /TU="NA" /idTUdmin="U259" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 351758..351765 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 351781..351800 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 351785 /Source="Nicolas_upshifts" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="upshifts" CDS 351826..353259 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18069788" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18069788; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_388223.1" /db_xref="EnsemblGenomes-Gn:BSU03410" /db_xref="EnsemblGenomes-Tr:CAB12135" /db_xref="GOA:P42403" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11181" /db_xref="UniProtKB/Swiss-Prot:P42403" /translation="MIHQHPESFPKHFLWGSASAAYQIEGAWNEDGKGPSVWDVFTKI PGKTFKGTNGEIAVDHYHRFKEDVALMAEMGLKAYRFSVSWPRVFPKGKGEINEAGLA FYDSLIDELLSHHIEPVLTLYHWDLPQALMDEYGGFESRNIIEDFNHYCITLYKRFGD RVKYWVTLNEQNYNFNHGFITAMHPPGVKDRKRFYEANHIAFLANAKAIESFREYVPE GKIGPSFAYSPAYPLSSHPEDILAFENAEEFTNNWWLDMYCWGTYPQIPFRCLEKQGW APTIEAGDMDLLAKGKPDFVGVNYYQTITYERNPLDGVSEGKMNTTGQKGTNQETGIP GVFKTKKNPHLTTSNWDWTIDPIGLRIGLRRITSRYQLPVFITENGLGEFDKVEDGTV QDDYRIDYLRSHLEQCRQAISDGVDLIGYCSWSFTDLLSWLNGYQKRYGFVYVNRDEE STSDLKRLKKKSFYWYQDVIKTNGESL*" /label="bglC CDS" gene 351826..353259 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /label="bglC gene" downshifts 353237 /Source="Nicolas_upshifts" /id="D151" /incds=0 /nref=12 /ntot=61 /MaxReadThrough="1.51167" /MaxDrop="4.6748" /score="18.0928088" /energy="-15.9" /TU="NA" /idTUdmin="U260" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(353296..353694) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11359569, 11814663, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11359569, 11814663, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the DNA degrading activity of NucA (competence)" /protein_id="NP_388224.1" /db_xref="EnsemblGenomes-Gn:BSU03420" /db_xref="EnsemblGenomes-Tr:CAB12136" /db_xref="GOA:P12669" /db_xref="InterPro:IPR020354" /db_xref="PDB:4MQD" /db_xref="SubtiList:BG10839" /db_xref="UniProtKB/Swiss-Prot:P12669" /translation="MIKSWKPQELSISYHQFTVFQKDSTPPVMDWTDEAIEKGYAAAD GAISFEAQRNTKAFILFRLNSSETVNSYEKKVTVPFHVTENGIHIESIMSKRLSFDLP KGDYQLTCWTVPAEMSDLHADTYIIDAVSV*" /label="nin CDS" gene complement(353296..353694) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /label="nin gene" promotor_no_box complement(353691..353791) /Source="Nicolas_upshift_promotors" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="promotor_no_box" CDS complement(353721..354170) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2841296, 7746143, 11359569, 11814663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2841296, 7746143, 11359569, 11814663; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease" /protein_id="NP_388225.3" /db_xref="EnsemblGenomes-Gn:BSU03430" /db_xref="EnsemblGenomes-Tr:CAB12137" /db_xref="GOA:P12667" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG10838" /db_xref="UniProtKB/Swiss-Prot:P12667" /translation="MNITTDIIKTILLVIVIIAAAAVGLIKGDFFSADQKTSQTKEYD ETMAFPSDRYPETAKHIKDAINEGHSEVCTIDRDGAEERREQSLKDVPSKKGYDRDEW PMAMCKEGGEGASVEYISPADNRGAGSWVGHRLTDYPDGTKVLFTIQ*" /label="nucA CDS" gene complement(353721..354170) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /label="nucA gene" upshifts complement(353731) /Source="Nicolas_upshifts" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(354185..354204) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(354193) /Source="Nicolas_upshifts" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(354195..354337) /Source="Nicolas_S_feature" /locus_tag="new_372628_372770_c" /HighExp="C30, Diami, M40t45, Cold, Lbstat, T0.30H, M0t90, dia15, C90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD" /TUshortPSig="0.0879, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S124" promotor_-35 complement(354218..354225) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(354338..356059) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7704255, 7921238, 15187186, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704255, 7921238, 15187186, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (plant colonization)" /protein_id="NP_388226.2" /db_xref="EnsemblGenomes-Gn:BSU03440" /db_xref="EnsemblGenomes-Tr:CAB12138" /db_xref="GOA:P39209" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="SubtiList:BG10790" /db_xref="UniProtKB/Swiss-Prot:P39209" /translation="MLIKRFKMKLGTKILCLVFVVILLFSASVGTVMLKEITESMKQM ATEKAKGDLALSSTYIDDVMSGDWQVKNNKLYKGQTQINGNEDIVDLLGEKTGDTITI FQGDTRVATNVMKNGERAVGTQASSEVIAAVLKKGKRFYGQADVAGSSYQTAYMPLKD QNGNIIGMLYTGANQSILASLTQSLFTQFAIVLVIVIMVSVILVLVFTRKINKRLNAL KSAFESAGNGDMTIEVSDKTGDELSELSVYYNKMRMKLNDTIQTVQQSALQLASASQQ LSAGAEETNQASEKITEAVQQIANGAQDQITRIENSESSLKQASADIRDISANTAAIA DKGQLAQSKADIGQKEIANVQAQMDAIHQSIQKSGEIIHQLDGRSKQIEQILSVITQI ADQTNLLALNAAIEAARAGEQGKGFAVVADEVRKLAEESQQSAGQISKLIIEIQKDMN RSARSVEHVKTEAAEGVTMIQRTRDAFKEIAAATGEISAEISDLSASVTNISASAHQI NDSFAANTADIKESTKNTRQAAALTEEQFAAMEEITAASETLSQLAEELTGIISQFKM INQAENG*" /label="tlpC CDS" gene complement(354338..356059) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /label="tlpC gene" promotor_-35 354350..354357 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 354368..357511 /Source="Nicolas_S_feature" /locus_tag="new_372801_375944" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, T4.0H, T0.0H, T-0.40H" /AntisenseName="tlpC" /AntisenseCor="-0.40398083053643302" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S125" upshifts 354368 /Source="Nicolas_upshifts" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 354372..354391 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box complement(354373..354473) /Source="Nicolas_upshift_promotors" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="promotor_no_box" upshifts complement(354413) /Source="Nicolas_upshifts" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="upshifts" promotor_-10 complement(356083..356101) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-10" upshifts complement(356098) /Source="Nicolas_upshifts" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="upshifts" promotor_-35 complement(356115..356122) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-35" CDS complement(356170..356727) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /EC_number="5.3.1.27" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-3-hexuloisomerase (PHI)" /protein_id="NP_388227.1" /db_xref="EnsemblGenomes-Gn:BSU03450" /db_xref="EnsemblGenomes-Tr:CAB12139" /db_xref="GOA:P42404" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR017552" /db_xref="PDB:1M3S" /db_xref="PDB:1VIV" /db_xref="SubtiList:BG11182" /db_xref="UniProtKB/Swiss-Prot:P42404" /translation="MKTTEYVAEILNELHNSAAYISNEEADQLADHILSSHQIFTAGA GRSGLMAKSFAMRLMHMGFNAHIVGEILTPPLAEGDLVIIGSGSGETKSLIHTAAKAK SLHGIVAALTINPESSIGKQADLIIRMPGSPKDQSNGSYKTIQPMGSLFEQTLLLFYD AVILKLMEKKGLDSETMFTHHANLE*" /label="hxlB CDS" gene complement(356170..356727) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /label="hxlB gene" downshifts complement(356173) /Source="Nicolas_upshifts" /id="D152" /incds=0 /nref=51 /ntot=130 /MaxReadThrough="1.98332" /MaxDrop="6.56052" /score="42.3682356" /energy="-15.4" /TU="NA" /idTUdmin="U266" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(356733..357365) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /EC_number="4.1.2.43" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hexulose-6-phosphate synthase (HPS)" /protein_id="NP_388228.1" /db_xref="EnsemblGenomes-Gn:BSU03460" /db_xref="EnsemblGenomes-Tr:CAB12140" /db_xref="GOA:P42405" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017553" /db_xref="SubtiList:BG11183" /db_xref="UniProtKB/Swiss-Prot:P42405" /translation="MELQLALDLVNIPEAIELVKEVEQYIDVVEIGTPVVINEGLRAV KEIKEAFPQLKVLADLKIMDAGGYEIMKASEAGADIITVLGATDDATIKGAVEEAKKQ KKKILVDMINVKDIESRAKEIDALGVDYICVHTGYDLQAEGKNSFEELTTIKNTVKNA KTAIAGGIKLDTLPEVIQQKPDLVIVGGGITSAADKAETASKMKQLIVQG*" /label="hxlA CDS" gene complement(356733..357365) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /label="hxlA gene" promotor_-10 complement(357391..357410) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(357406) /Source="Nicolas_upshifts" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(357425..357428) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 357489..357492 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 357507..357526 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 357513 /Source="Nicolas_upshifts" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="upshifts" CDS 357599..357961 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15978081, 26973631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15978081, 26973631; Product type r: regulator" /codon_start=1 /transl_table=11 /product="positive regulator of hxlAB expression (formaldehyde sensing)" /protein_id="NP_388229.2" /db_xref="EnsemblGenomes-Gn:BSU03470" /db_xref="EnsemblGenomes-Tr:CAB12141" /db_xref="GOA:P42406" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11184" /db_xref="UniProtKB/Swiss-Prot:P42406" /translation="MSRMDDKRFNCEKELTLAVIGGKWKMLILWHLGKEGTKRFNELK TLIPDITQKILVNQLRELEQDMIVHREVYPVVPPKVEYSLTPHGESLMPILEAMYEWG KGYMELIDIDKNVMKESL*" /label="hxlR CDS" gene 357599..357961 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /label="hxlR gene" downshifts 357945 /Source="Nicolas_upshifts" /id="D153" /incds=0 /nref=14 /ntot=154 /MaxReadThrough="3.13609" /MaxDrop="3.66949" /score="20.4643411" /energy="-9.6" /TU="U267" /idTUdmin="U263" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 358208..358211 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 358226..358245 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 358234..358534 /Source="Nicolas_S_feature" /locus_tag="new_376667_376967" /HighExp="HiOs, T-1.10H, T5.0H, T4.0H, T-1.40H, S2, M9-stat, T3.30H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.20585600000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S126" upshifts 358234 /Source="Nicolas_upshifts" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="upshifts" CDS 358535..369298 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388230.2" /db_xref="EnsemblGenomes-Gn:BSU03480" /db_xref="EnsemblGenomes-Tr:CAB12142" /db_xref="GOA:P27206" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10168" /db_xref="UniProtKB/Swiss-Prot:P27206" /translation="MEITFYPLTDAQKRIWYTEKFYPHTSISNLAGIGKLVSADAIDY VLVEQAIQEFIRRNDAMRLRLRLDENGEPVQYISEYRPVDIKHTDTTEDPNAIEFISQ WSREETKKPLPLYDCDLFRFSLFTIKENEVWFYANVHHVISDGISMNILGNAIMHIYL ELASGSETKEGISHSFIDHVLSEQEYAQSKRFEKDKAFWNKQFESVPELVSLKRNASA GGSLDAERFSKDVPEALHQQILSFCEANKVSVLSVFQSLLAAYLYRVSGQNDVVTGTF MGNRTNAKEKQMLGMFVSTVPLRTNIDGGQAFSEFVKDRMKDLMKTLRHQKYPYNLLI NDLRETKSSLTKLFTVSLEYQVMQWQKEEDLAFLTEPIFSGSGLNDVSIHVKDRWDTG KLTIDFDYRTDLFSREEINMICERMITMLENALTHPEHTIDELTLISDAEKEKLLARA GGKSVSYRKDMTIPELFQEKAELLSDHPAVVFEDRTLSYRTLHEQSARIANVLKQKGV GPDSPVAVLIERSERMITAIMGILKAGGAYVPIDPGFPAERIQYILEDCGADFILTES KVAAPEADAELIDLDQAIEEGAEESLNADVNARNLAYIIYTSGTTGRPKGVMIEHRQV HHLVESLQQTIYQSGSQTLRMALLAPFHFDASVKQIFASLLLGQTLYIVPKKTVTNGA ALTAYYRKNSIEATDGTPAHLQMLAAAGDFEGLKLKHMLIGGEGLSSVVADKLLKLFK EAGTAPRLTNVYGPTETCVDASVHPVIPENAVQSAYVPIGKALGNNRLYILDQKGRLQ PEGVAGELYIAGDGVGRGYLHLPELTEEKFLQDPFVPGDRMYRTGDVVRWLPDGTIEY LGREDDQVKVRGYRIELGEIEAVIQQAPDVAKAVVLARPDEQGNLEVCAYVVQKPGSE FAPAGLREHAARQLPDYMVPAYFTEVTEIPLTPSGKVDRRKLFALEVKAVSGTAYTAP RNETEKAIAAIWQDVLNVEKAGIFDNFFETGGHSLKAMTLLTKIHKETGIEIPLQFLF EHPTITALAEEADHRESKAFAVIEPAEKQEHYPLSLAQQRTYIVSQFEDAGVGYNMPA AAILEGPLDIQKLERAFQGLIRRHESLRTSFVLENSTPRQKIHDSVDFNIEMIERGGR SDEAIMASFVRTFDLAKAPLFRIGLLGLEENRHMLLFDMHHLISDGVSIGIMLEELAR IYKGEQLPDLRLQYKDYAVWQSRQAAEGYKKDQAYWKEVFAGELPVLQLLSDYPRPPV QSFEGDRVSIKLDAGVKDRLNRLAEQNGATLYMVMLSAYYTLLSKYTGQDDIIVGTPS AGRNHSDTEGIIGMFVNTLAIRSEVKQNETFTQLISRVRKRVLDAFSHQDYPFEWLVE DLNIPRDVSRHPLFDTMFSLQNATEGIPAVGDLSLSVQETNFKIAKFDLTVQARETDE GIEIDVDYSTKLFKQSTADRLLTHFARLLEDAAADPEKPISEYKLLSEEEAASQIQQF NPGRTPYPKDKTIVQLFEEQAANTPDHTALQYEGESLTYRELNERANRLARGILSLGA GEGRTAAVLCERSMDMIVSILAVLKSGSAYVPIDPEHPIQRMQHFFRDSGAKVLLTQR KLKALAEEAEFKGVIVLADEEESYHADARNLALPLDSAAMANLTYTSGTTGTPKGNIV THANILRTVKETNYLSITEQDTILGLSNYVFDAFMFDMFGSLLNGAKLVLIPKETVLD MARLSRVIERENISILMITTALFHLLVDLNPACLSTLRKIMFGGERASVEHVRKALQT VGKGKLLHMYGPSESTVFATYHPVDELEEHTLSVPIGKPVSNTEVYILDRTGHVQPAG IAGELCVSGEGLVKGYYNRPELTEEKFVPHPFTSGERMYKTGDLARWLPNGDIEFIGR IDHQVKIRGQRIELGEIEHQLQTHDRVQESVVLAVDQGAGDKLLCAYYVGEGDISSQE MREHAAKDLPAYMVPAVFIQMDELPLTGNGKIDRRALPIPDANVSRGVSYVAPRNGTE QKVADIWAQVLQAEQVGAYDHFFDIGGHSLAGMKMLALVHQELGVELSLKDLFQSPTV EGLAQVIASAEKGTAASISPAEKQDTYPVSSPQKRMYVLQQLEDAQTSYNMPAVLRLT GELDVERLNSVMQQLMQRHEALRTTFEIKDGETVQRIWEEAECEIAYFEAPEEETERI VSEFIKPFKIDQLPLFRIGLIKHSDTEHVLLFDMHHIISDGASVGVLIEELSKLYDGE TLEPLRIQYKDYAVWQQQFIQSELYKKQEEHWLKELDGELPVLTLPTDYSRPAVQTFE GDRIAFSLEAGKADALRRLAKETDSTLYMVLLASYSAFLSKISGQDDIIVGSPVAGRS QADVSRVIGMFVNTLALRTYPKGEKTFADYLNEVKETALSAFDAQDYPLEDLIGNVQV QRDTSRNPLFDAVFSMQNANIKDLTMKGIQLEPHPFERKTAKFDLTLTADETDGGLTF VLEYNTALFKQETIERWKQYWMELLDAVTGNPNQPLSSLSLVTETEKQALLEAWKGKA LPVPTDKTVHQLFEETAQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDD RVGVLTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISV PDSYTGDVILLDGSRTILSLPLDENDEENPETAVTAENLAYMIYTSGTTGQPKGVMVE HHALVNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIEEAIRLD IVRLNDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNY GPTENTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLA RGYLNREDETAKRFVADPFVPGERMYRTGDLVKWTGGGIEYIGRIDQQVKVRGYRIEL SEIEVQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPESADIEALKSALKETLPDYMIP AFWVTLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEV GVTDNFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQ GPVEGEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDAL RMVYREGQEDVIQYNRGLEAASAQLEVIQIEGQAADYEDRIEREAERLQSSIDLQEGG LLKAGLFQAEDGDHLLLAIHHLVVDGVSWRILLEDFAAVYTQLEQGNEPVLPQKTHSF AEYAERLQDFANSKAFLKEKEYWRQLEEQAVAAKLPKDRESGDQRMKHTKTIEFSLTA EETEQLTTKVHEAYHTEMNDILLTAFGLAMKEWTGQDRVSVHLEGHGREEIIEDLTIS RTVGWFTSMYPMVLDMKHADDLGYQLKQMKEDIRHVPNKGVGYGILRYLTAPEHKEDV AFSIQPDVSFNYLGQFDEMSDAGLFTRSELPSGQSLSPETEKPNALDVVGYIENGKLT MSLAYHSLEFHEKTVQTFSDSFKAHLLRIIEHCLSQDGTELTPSDLGDDDLTLDELDK LMEIF*" /label="srfAA CDS" gene 358535..369298 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /label="srfAA gene" CDS 369311..380062 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388231.2" /db_xref="EnsemblGenomes-Gn:BSU03490" /db_xref="EnsemblGenomes-Tr:CAB12143" /db_xref="GOA:Q04747" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10169" /db_xref="UniProtKB/Swiss-Prot:Q04747" /translation="MSKKSIQKVYALTPMQEGMLYHAMLDPHSSSYFTQLELGIHGAF DLEIFEKSVNELIRSYDILRTVFVHQQLQKPRQVVLAERKTKVHYEDISHADENRQKE HIERYKQDVQRQGFNLAKDILFKVAVFRLAADQLYLVWSNHHIMMDGWSMGVLMKSLF QNYEALRAGRTPANGQGKPYSDYIKWLGKQDNEEAESYWSERLAGFEQPSVLPGRLPV KKDEYVNKEYSFTWDETLVARIQQTANLHQVTGPNLFQAVWGIVLSKYNFTDDVIFGT VVSGRPSEINGIETMAGLFINTIPVRVKVERDAAFADIFTAVQQHAVEAERYDYVPLY EIQKRSALDGNLLNHLVAFENYPLDQELENGSMEDRLGFSIKVESAFEQTSFDFNLIV YPGKTWTVKIKYNGAAFDSAFIERTAEHLTRMMEAAVDQPAAFVREYGLVGDEEQRQI VEVFNSTKAELPEGMAVHQVFEEQAKRTPASTAVVYEGTKLTYRELNAAANRLARKLV EHGLQKGETAAIMNDRSVETVVGMLAVLKAGAAYVPLDPALPGDRLRFMAEDSSVRMV LIGNSYTGQAHQLQVPVLTLDIGFEESEAADNLNLPSAPSDLAYIMYTSGSTGKPKGV MIEHKSILRLVKNAGYVPVTEEDRMAQTGAVSFDAGTFEVFGALLNGAALYPVKKETL LDAKQFAAFLREQSITTMWLTSPLFNQLAAKDAGMFGTLRHLIIGGDALVPHIVSKVK QASPSLSLWNGYGPTENTTFSTSFLIDREYGGSIPIGKPIGNSTAYIMDEQQCLQPIG APGELCVGGIGVARGYVNLPELTEKQFLEDPFRPGERIYRTGDLARWLPDGNIEFLGR IDNQVKVRGFRIELGEIETKLNMAEHVTEAAVIIRKNKADENEICAYFTADREVAVSE LRKTLSQSLPDYMVPAHLIQMDSLPLTPNGKINKKELPAPQSEAVQPEYAAPKTESEK KLAEIWEGILGVKAGVTDNFFMIGGHSLKAMMMTAKIQEHFHKEVPIKVLFEKPTIQE LALYLEENESKEEQTFEPIRQASYQQHYPVSPAQRRMYILNQLGQANTSYNVPAVLLL EGEVDKDRLENAIQQLINRHEILRTSFDMIDGEVVQTVHKNISFQLEAAKGREEDAEE IIKAFVQPFELNRAPLVRSKLVQLEEKRHLLLIDMHHIITDGSSTGILIGDLAKIYQG ADLELPQIHYKDYAVWHKEQTNYQKDEEYWLDVFKGELPILDLPADFERPAERSFAGE RVMFGLDKQITAQIKSLMAETDTTMYMFLLAAFNVLLSKYASQDDIIVGSPTAGRTHP DLQGVPGMFVNTVALRTAPAGDKTFAQFLEEVKTASLQAFEHQSYPLEELIEKLPLTR DTSRSPLFSVMFNMQNMEIPSLRLGDLKISSYSMLHHVAKFDLSLEAVEREEDIGLSF DYATALFKDETIRRWSRHFVNIIKAAAANPNVRLSDVDLLSSAETAALLEERHMTQIT EATFAALFEKQAQQTPDHSAVKAGGNLLTYRELDEQANQLAHHLRAQGAGNEDIVAIV MDRSAEVMVSILGVMKAGAAFLPIDPDTPEERIRYSLEDSGAKFAVVNERNMTAIGQY EGIIVSLDDGKWRNESKERPSSISGSRNLAYVIYTSGTTGKPKGVQIEHRNLTNYVSW FSEEAGLTENDKTVLLSSYAFDLGYTSMFPVLLGGGELHIVQKETYTAPDEIAHYIKE HGITYIKLTPSLFHTIVNTASFAKDANFESLRLIVLGGEKIIPTDVIAFRKMYGHTEF INHYGPTEATIGAIAGRVDLYEPDAFAKRPTIGRPIANAGALVLNEALKLVPPGASGQ LYITGQGLARGYLNRPQLTAERFVENPYSPGSLMYKTGDVVRRLSDGTLAFIGRADDQ VKIRGYRIEPKEIETVMLSLSGIQEAVVLAVSEGGLQELCAYYTSDQDIEKAELRYQL SLTLPSHMIPAFFVQVDAIPLTANGKTDRNALPKPNAAQSGGKALAAPETALEESLCR IWQKTLGIEAIGIDDNFFDLGGHSLKGMMLIANIQAELEKSVPLKALFEQPTVRQLAA YMEASAVSGGHQVLKPADKQDMYPLSSAQKRMYVLNQLDRQTISYNMPSVLLMEGELD ISRLRDSLNQLVNRHESLRTSFMEANGEPVQRIIEKAEVDLHVFEAKEDEADQKIKEF IRPFDLNDAPLIRAALLRIEAKKHLLLLDMHHIIADGVSRGIFVKELALLYKGEQLPE PTLHYKDFAVWQNEAEQKERMKEHEAYWMSVLSGELPELDLPLDYARPPVQSFKGDTI RFRTGSETAKAVEKLLAETGTTLHMVLHAVFHVFLSKISGQRDIVIGSVTAGRTNADV QDMPGMFVNTLALRMEAKEQQTFAELLELAKQTNLSALEHQEYPFEDLVNQLDLPRDM SRNPLFNVMVTTENPDKEQLTLQNLSISPYEAHQGTSKFDLTLGGFTDENGIGLQLEY ATDLFAKETAEKWSEYVLRLLKAVADNPNQPLSSLLLVTETEKQALLEAWKGKALPVP TDKTVHQLFEETVQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDDRVGV LTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISVPDSY TGDVILLDGSRTILSLPLDENDEGNPETAVTAENLAYMIYTSGTTGQPKGVMVEHHAL VNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIDEAIRLDIVRL NDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNYGPTE NTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLARGYL NREDETAKRFVADPFVPGERMYRTGDLVKWVNGGIEYIGRIDQQVKVRGYRIELSEIE VQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPETADIEALKSTLKETLPDYMIPAFWV TLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEVGVTD NFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQGPVE GEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDALRMVY REENGDIVQVYKPIGESKVSFEIVDLYGSDEEMLRSQIKLLANKLQSSLDLRNGPLLK AEQYRTEAGDHLLIAVHHLVVDGVSWRILLEDFASGYMQAEKEESLVFPQKTNSFKDW AEELAAFSQSAHLLQQAEYWSQIAAEQVSPLPKDCETEQRIVKDTSSVLCELTAEDTK HLLTDVHQPYGTEINDILLSALGLTMKEWTKGAKIGINLEGHGREDIIPNVNISRTVG WFTAQYPVVLDISDADASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEIS FNYLGQFDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGRFVLSCSYNEKE FERATVEEQMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGDIFDMLEENL K*" /label="srfAB CDS" gene 369311..380062 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /label="srfAB gene" CDS 372447..372587 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10361283, 16554821, 8752331, 9696775, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 16554821, 8752331, 9696775, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of genetic competence" /protein_id="NP_388232.1" /db_xref="EnsemblGenomes-Gn:BSU03500" /db_xref="EnsemblGenomes-Tr:CAB12144" /db_xref="GOA:P80355" /db_xref="InterPro:IPR035139" /db_xref="SubtiList:BG11045" /db_xref="UniProtKB/Swiss-Prot:P80355" /translation="MNRSGKHLISSIILYPRPSGECISSISLDKQTQATTSPLYFCWR EK*" /label="comS CDS" gene 372447..372587 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /label="comS gene" CDS 380099..383926 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388233.2" /db_xref="EnsemblGenomes-Gn:BSU03510" /db_xref="EnsemblGenomes-Tr:CAB12145" /db_xref="GOA:Q08787" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="PDB:1JMK" /db_xref="PDB:2VSQ" /db_xref="SubtiList:BG10170" /db_xref="UniProtKB/Swiss-Prot:Q08787" /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVK GSLNIKCLEESMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSE QTAKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQ DLFKVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEGFEGQTTFAEQ RKKQKDGYEPKELLFSLSEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLA FGTVVSGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKRLQEQSLQSEPHQYV PLYDIQSQADQPKLIDHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMA SPGDEMLIKLAYNENVFDEAFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFL LTGLNPPAQAHETKPLTYWFKEAVNANPDAPALTYSGQTLSYRELDEEANRIARRLQK HGAGKGSVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLL THQEMKEQAAELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKG NITTHANIQGLVKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHT LLDTERLTDLILQENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKA LRIMGPGKLINCYGPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQ PFGAVGELCISGMGVSKGYVNRADLTKEKFIENPFKPGETLYRTGDLARWLPDGTIEY AGRIDDQVKIRGHRIELEEIEKQLQEYPGVKDAVVVADRHESGDASINAYLVNRTQLS AEDVKAHLKKQLPAYMVPQTFTFLDELPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNE MEETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAP TIAGISAYLKNGGSDGLQDVTIMNQDQEQIIFAFPPVLGYGLMYQNLSSRLPSYKLCA FDFIEEEDRLDRYADLIQKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMV DSYKKQGVSDLDGRTVESDVEALMNVNRDNEALNSEAVKHGLKQKTHAFYSYYVNLIS TGQVKADIDLLTSGADFDMPEWLASWEEATTGVYRVKRGFGTHAEMLQGETLDRNAEI LLEFLNTQTVTVS*" /label="srfAC CDS" gene 380099..383926 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /label="srfAC gene" CDS 383955..384683 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388234.1" /db_xref="EnsemblGenomes-Gn:BSU03520" /db_xref="EnsemblGenomes-Tr:CAB12146" /db_xref="GOA:Q08788" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR012223" /db_xref="InterPro:IPR029058" /db_xref="PDB:2K2Q" /db_xref="PDB:2RON" /db_xref="SubtiList:BG10171" /db_xref="UniProtKB/Swiss-Prot:Q08788" /translation="MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLA AEPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLERE GIFPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSF RSDYRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMF LLSQTEEVAERIFAILNQHPIIQP*" /label="srfAD CDS" gene 383955..384683 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /label="srfAD gene" downshifts 384665 /Source="Nicolas_upshifts" /id="D154" /incds=0 /nref=196 /ntot=261 /MaxReadThrough="4.65721" /MaxDrop="6.48992" /score="24.9581454" /energy="-11.1" /TU="U268" /idTUdmin="U268" /TUdmin="-1339" /isTUend="FALSE" /label="downshifts" promotor_-35 384721..384728 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 384731 /Source="Nicolas_upshifts" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 384740..384759 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 384784..386010 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15849754, 16850406, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter" /protein_id="NP_388235.2" /db_xref="EnsemblGenomes-Gn:BSU03530" /db_xref="EnsemblGenomes-Tr:CAB12147" /db_xref="GOA:Q08791" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10172" /db_xref="UniProtKB/Swiss-Prot:Q08791" /translation="MRTSPRMKWFVLLFTFVFAIGMNSFRNSFQFFMLPMADAFHADR SLISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLVLPYSPNVHVFS AIYGVLGGIGYSCAVGVTTQYFISCWFDTHKGLALAILTNANSAGLLLLSPIWAAAPY HAGWQSTYTILGIVMAAVLLPLLVFGMKHPPHAQAETVKKSYDWRGFWNVMKQSRLIH ILYFGVFTCGFTMGIIDAHLVPILKDAHVSHVNGMMAAFGAFIIIGGLLAGWLSDLLG SRSVMLSILFFIRLLSLICLLIPILGIHHSDLWYFGFILLFGLSYTGVIPLTAASISE SYQTGLIGSLLGINFFIHQVAGALSVYAGGLFFDMTHGYLLIVAVCIVFVGLSAVIEL VPFLDKQKAKETHHSI*" /label="srfT CDS" gene 384784..386010 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /label="srfT gene" downshifts 386004 /Source="Nicolas_upshifts" /id="D155" /incds=0 /nref=15 /ntot=198 /MaxReadThrough="2.67601" /MaxDrop="4.06773" /score="7.33278866" /energy="-13.2" /TU="NA" /idTUdmin="U268" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(386025..386582) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 21965396" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388236.1" /db_xref="EnsemblGenomes-Gn:BSU03540" /db_xref="EnsemblGenomes-Tr:CAB12148" /db_xref="GOA:Q08793" /db_xref="InterPro:IPR025588" /db_xref="SubtiList:BG10173" /db_xref="UniProtKB/Swiss-Prot:Q08793" /translation="MIQYASESINLPGEITFKDVREIFFYQIAKISCFYFLLFCAIFA AVNFINGWPRIVYGSDALNLFMNSMLIIVMSVLFTLLLLLLLYVKFSRAYKKNERMKS KRTYTLNQEGIRICSKKYDLIFNWDEITAVFEYKNIFRVNTSSGQYIAIPKHFFHSEE EMNRFKEIILKNTETKKLKFKKDQH*" /label="ycxB CDS" gene complement(386025..386582) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /label="ycxB gene" promotor_no_box complement(386040..386140) /Source="Nicolas_upshift_promotors" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(386062) /Source="Nicolas_upshifts" /id="D156" /incds=0 /nref=46 /ntot=241 /MaxReadThrough="0.9216" /MaxDrop="4.25654" /score="8.42655219" /energy="-14.3" /TU="U270" /idTUdmin="U271" /TUdmin=18 /isTUend="TRUE" /label="downshifts" upshifts complement(386080) /Source="Nicolas_upshifts" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(386611..386630) /Source="Nicolas_upshift_promotors" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(386613) /Source="Nicolas_upshifts" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(386636..387574) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388237.2" /db_xref="EnsemblGenomes-Gn:BSU03550" /db_xref="EnsemblGenomes-Tr:CAB12149" /db_xref="GOA:Q08794" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10174" /db_xref="UniProtKB/Swiss-Prot:Q08794" /translation="MVKHQQTPAYIAAILYSFIIGLSFLFVKIALQTAEPFDILAHRF TIAFAAATVPILFGWVKLSIRVKDVIDILPLALLYPALFFSFQAFGLVYSSSSEAGII QAAIPIFTMVFAAYVLKERPTWTQKGFTVLSVAGVMFIFVMKGVDVESASLKGSLLIL LSALSSAMYNTAARKMTQRFKLTELTYIMSAIGFVVFNAIALVRHGAAGTVGTYFLPF REPGFVLAIVYLGVLSSLVTSFLSNYTLSRIEAFKMSAFNHVSTIVTMIAGFVILNES LAWYHLAGAVCIMIGVVGSNINLEKKTKRPGMPAKK*" /label="ycxC CDS" gene complement(386636..387574) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /label="ycxC gene" promotor_-10 complement(387613..387631) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(387620) /Source="Nicolas_upshifts" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(387647..387652) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 387698..389032 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 26585522; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388238.1" /db_xref="EnsemblGenomes-Gn:BSU03560" /db_xref="EnsemblGenomes-Tr:CAB12150" /db_xref="GOA:Q08792" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10175" /db_xref="UniProtKB/Swiss-Prot:Q08792" /translation="MEKYMSLLTRIEEMMQSTSYQEGDRLPSIRQLSARYQVSKSTVI RALQELEKRHLIYSVPKSGYYIVKKSGKSKSGQPGPIDFATSAPDPDVFPYLDFQHCI NKAIDTYKNDLFIYGTPKGLPSLIRVLRKLLATQQVFADERHIFITSGVQQALSLLCA MPFPNGKEKIAIEQPGYHLMVEQLETLGIPAIGVKRTEEGLDIAKVERLFQTESIKFF YTMPRFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGDLEENKKADPLYAYDLSS HVIYLKSFSKMMFPGLRVGAAVLPEALTDTFYAYKKLNDIDCSMISQAALEIYLKSGM YGRHKEKIRDSYKERSLRLHQAIRTHRQLGSGRFTFSSGQAPCMHTHLVLPQDLPASR VIHRLEKQGVLLEAIDRHYLSDYPKENLLKINISNVKTEDIERGVKLLMSHL*" /label="ycxD CDS" gene 387698..389032 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /label="ycxD gene" CDS complement(389027..389194) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="C-terminal part of 4'-phosphopantetheinyl transferase (Surfactin synthetase-activating enzyme)" /db_xref="PSEUDO:CAX52545.1" /translation="MRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAVHPDFPE DITMVSYEELL*" /label="sfpAc CDS" gene complement(389027..389194) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /pseudo /label="sfpAc gene" CDS complement(389205..389702) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="N-terminal part of 4'-phosphopantetheinyl transferase (surfactin synthetase-activating enzyme)" /db_xref="GOA:P39135" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1QR0" /db_xref="PDB:2GE0" /db_xref="PDB:2GE1" /db_xref="PDB:4MRT" /db_xref="PSEUDO:CAB12151.2" /db_xref="SubtiList:BG10176" /db_xref="UniProtKB/Swiss-Prot:P39135" /translation="MKIYGIYMDRPLSQEENERFMSFISPEKREKCRRFYHKEDAHRT LLGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVICAFDSQ PIGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQGRQR LIASA*" /label="sfpAn CDS" gene complement(389205..389702) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /pseudo /label="sfpAn gene" misc_feature complement(389729..389748) /Source="Nicolas_upshift_promotors" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(389741) /Source="Nicolas_upshifts" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" CDS complement(389807..390454) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /function="15.11: Biosynthesis of natural products" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17827323, 14762003, 16707694, 17827323, 25288929; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein regulating antibiotic production" /protein_id="NP_388240.2" /db_xref="EnsemblGenomes-Gn:BSU03580" /db_xref="EnsemblGenomes-Tr:CAB12152" /db_xref="GOA:O34927" /db_xref="SubtiList:BG12779" /db_xref="UniProtKB/Swiss-Prot:O34927" /translation="MKQELVLRWTFYFAGLIILAFGVSLTIEGKALGISPWDAFHYSL FQHFGLTVGQWSIIIGALIVGFTSLFTRAWPKIGALLNMVLIGVFIDFFNFILPALST YTGSIIVFSLGVVLIGYGVGVYVSAGLGAGPRDSLMMLITEKTGWNVQWVRNGMELTI LFAAWGMGGPIGFGTILTAILTGLILRFSLPQSIQLLNYAVARRTAAVKASPPVH*" /label="yczE CDS" gene complement(389807..390454) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /label="yczE gene" promotor_-10 complement(390483..390502) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(390486) /Source="Nicolas_upshifts" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(390518..390522) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(390623..390774) /Source="Nicolas_S_feature" /locus_tag="new_409056_409207_c" /HighExp="G180, G135, dia15, H2O2, Diami, S8, Oxctl, G150, LPhT, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S127" CDS complement(390775..391518) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 16513748, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 16513748, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (ATP-binding protein)" /protein_id="NP_388241.2" /db_xref="EnsemblGenomes-Gn:BSU03590" /db_xref="EnsemblGenomes-Tr:CAB12153" /db_xref="GOA:P39456" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11185" /db_xref="UniProtKB/Swiss-Prot:P39456" /translation="MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLL RCLNALEIPNRGELAFDDFSIDFSKKVKQADILKLRRKSGMVFQAYHLFPHRTALENV MEGPVQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPE LMLFDEPTSALDPELVGEVLKVIKDLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVI VEQGPPEQIFSAPKEERTQRFLNRILNPL*" /label="tcyC CDS" gene complement(390775..391518) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /label="tcyC gene" downshifts complement(390831) /Source="Nicolas_upshifts" /id="D157" /incds=0 /nref=72 /ntot=232 /MaxReadThrough="4.60958" /MaxDrop="4.44283" /score="1.62131565" /energy="-12.6" /TU="U275" /idTUdmin="U276" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(391532..392236) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 15849754, 16850406, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 15849754, 16850406, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (permease)" /protein_id="NP_388242.1" /db_xref="EnsemblGenomes-Gn:BSU03600" /db_xref="EnsemblGenomes-Tr:CAB12154" /db_xref="GOA:P42200" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11186" /db_xref="UniProtKB/Swiss-Prot:P42200" /translation="MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFI FGMILALITALARMSKVRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFP SAVIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIP PLSNTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLS LVQHVIERRLDRYVAK*" /label="tcyB CDS" gene complement(391532..392236) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /label="tcyB gene" CDS complement(392223..393029) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (substrate-binding lipoprotein)" /protein_id="NP_388243.2" /db_xref="EnsemblGenomes-Gn:BSU03610" /db_xref="EnsemblGenomes-Tr:CAB12155" /db_xref="GOA:P42199" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11187" /db_xref="UniProtKB/Swiss-Prot:P42199" /translation="MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKK GVLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLN SKRFDVVANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLT SNYNKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAF ETGEPQSTYFTFRKGSGEVVDQVNKALKEMKEDGTLSKISKKWFGEDVSK*" /label="tcyA CDS" gene complement(392223..393029) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /label="tcyA gene" promotor_-10 complement(393078..393097) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(393090) /Source="Nicolas_upshifts" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(393111..393118) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(393145..394017) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17295427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17295427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="HTH-type transcriptional regulator BsdA (LysR family)" /protein_id="NP_388244.1" /db_xref="EnsemblGenomes-Gn:BSU03620" /db_xref="EnsemblGenomes-Tr:CAB12156" /db_xref="GOA:P94403" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12022" /db_xref="UniProtKB/Swiss-Prot:P94403" /translation="MDIRQLRYFITIAQEQKITSAAKKLHMAQPPLSRQLKQLEDELG VVLFDRNKKKQMTLTYEGAVFLKRAKEILHRFEDAVIEVQELKEEVAGTLAVGSTIYC AALMLEKVTQIKERYPHLTFNIWENEPATLLELLESRQIDAAVTTTLIKSDTVQFKQL DDIPCVLVLSDEAGYPCGDTIKMVDIPSFPLILLRPVNGKGVYNQVMNEFHRLNLEPR IVCECHDSATLLSLVSSGFGASILPVTMIPVHMRNHVHTVHIENNPFIMTPAVMWRTD SYLPKPAQQFLDLF*" /label="bsdA CDS" gene complement(393145..394017) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /label="bsdA gene" promotor_-10 complement(393755..393773) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(393762) /Source="Nicolas_upshifts" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(393788..393794) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 394071..394078 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(394086..394105) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-10" promotor_-10 394092..394111 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(394092) /Source="Nicolas_upshifts" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="upshifts" upshifts 394100 /Source="Nicolas_upshifts" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="upshifts" CDS 394107..394721 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10919793, 15979273, 17295427, 18388975, 26083743, 26658822, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase-flavin prenyltransferase subunit" /protein_id="NP_388245.1" /db_xref="EnsemblGenomes-Gn:BSU03630" /db_xref="EnsemblGenomes-Tr:CAB12157" /db_xref="GOA:P94404" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR004507" /db_xref="InterPro:IPR032901" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG12023" /db_xref="UniProtKB/Swiss-Prot:P94404" /translation="MKAEFKRKGGGKVKLVVGMTGATGAIFGVRLLQWLKAAGVETHL VVSPWANVTIKHETGYTLQEVEQLATYTYSHKDQAAAISSGSFDTDGMIVAPCSMKSL ASIRTGMADNLLTRAADVMLKERKKLVLLTRETPLNQIHLENMLALTKMGTIILPPMP AFYNRPRSLEEMVDHIVFRTLDQFGIRLPEAKRWNGIEKQKGGA*" /label="ubiX CDS" gene 394107..394721 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /label="ubiX gene" promotor_-35 complement(394119..394126) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-35" CDS 394724..396145 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /EC_number="4.1.1.61" /EC_number="4.1.1.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11029449, 15979273, 17295427, 18388975, 26658822, 26337367; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phenolic acid decarboxylase subunit;1,4-dihydroxy-2-naphtoate-heptaprenyl diphosphatedecarboxylase" /protein_id="NP_388246.1" /db_xref="EnsemblGenomes-Gn:BSU03640" /db_xref="EnsemblGenomes-Tr:CAB12158" /db_xref="GOA:P94405" /db_xref="InterPro:IPR002830" /db_xref="InterPro:IPR012349" /db_xref="InterPro:IPR032902" /db_xref="SubtiList:BG12024" /db_xref="UniProtKB/Swiss-Prot:P94405" /translation="MAYQDFREFLAALEKEGQLLTVNEEVKPEPDLGASARAASNLGD KSPALLFNNIYGYHNARIAMNVIGSWPNHAMMLGMPKDTPVKEQFFEFAKRYDQFPMP VKREETAPFHENEITEDINLFDILPLFRINQGDGGYYLDKACVISRDLEDPDNFGKQN VGIYRMQVKGKDRLGIQPVPQHDIAIHLRQAEERGINLPVTIALGCEPVITTAASTPL LYDQSEYEMAGAIQGEPYRIVKSKLSDLDVPWGAEVVLEGEIIAGEREYEGPFGEFTG HYSGGRSMPIIKIKRVYHRNNPIFEHLYLGMPWTECDYMIGINTCVPLYQQLKEAYPN EIVAVNAMYTHGLIAIVSTKTRYGGFAKAVGMRALTTPHGLGYCKMVIVVDEDVDPFN LPQVMWALSTKMHPKHDAVIIPDLSVLPLDPGSNPSGITHKMILDATTPVAPETRGHY SQPLDSPLTTKEWEQKLMDLMNK*" /label="bsdC CDS" gene 394724..396145 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /label="bsdC gene" CDS 396162..396389 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /EC_number="4.1.1.91" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15979273, 17295427, 18388975, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase subunit" /protein_id="YP_003097675.1" /db_xref="EnsemblGenomes-Gn:BSU03651" /db_xref="EnsemblGenomes-Tr:CAX52546" /db_xref="GOA:C0H3U9" /db_xref="UniProtKB/Swiss-Prot:C0H3U9" /translation="MHTCPRCDSKKGEVMSKSPVEGAWEVYQCQTCFFTWRSCEPESI TNPEKYNPAFKIDPKETETAIEVPAVPERKA*" /label="bsdD CDS" gene 396162..396389 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /label="bsdD gene" CDS 396386..396850 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15979273, 18388975; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN-binding enzyme subunit" /protein_id="NP_388247.2" /db_xref="EnsemblGenomes-Gn:BSU03652" /db_xref="EnsemblGenomes-Tr:CAB12159" /db_xref="GOA:C0SPB5" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12025" /db_xref="UniProtKB/Swiss-Prot:C0SPB5" /translation="MIRVNCMSDRLFELLDGSCLNEKQHEAFVLQTVSEDGWPHAAMI SAGEIIALSRTDIRIALWKNTMTSANILRTGKAQFTAWWKGAAYYVKLECAPLPPLKD AEYERDRFSCRIVSVKEDVAKYADLTSGVRIQLHSPEEVLSRWKKTLEDLKR*" /label="yclD CDS" gene 396386..396850 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /label="yclD gene" downshifts 396831 /Source="Nicolas_upshifts" /id="D158" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="3.32586" /MaxDrop="3.88166" /score="45.8937489" /energy="-15.1" /TU="NA" /idTUdmin="U278" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 396857..396858 /Source="Nicolas_upshift_promotors" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 396858 /Source="Nicolas_upshifts" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 396917..397762 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388248.2" /db_xref="EnsemblGenomes-Gn:BSU03660" /db_xref="EnsemblGenomes-Tr:CAB12160" /db_xref="GOA:P94407" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12026" /db_xref="UniProtKB/Swiss-Prot:P94407" /translation="MERAGICHSDGFDLAYRIEGEGAPILVIGSAVYYPRLFSSDIKQ KYQWVFVDHRGFAKPKRELRAEDSRLDAVLADIERMRTFLQLEDVTILGHSGHAFMAL EYARTYPKQVRKVALFNTAPDNSEERQRKSESFFMETASLERKKRFEKDIENLPQDID KDPERRFVHMCIRAEAKSFYQERPHAAALWDGVFTNMPIIDELWGNTFARIDLLQRLA DVRMPVYIGLGRYDYLVAPVSLWDAVDGLYPHVDKVIFEKSGHQPMLEEPEAFDQSFR KWLDQ*" /label="yclE CDS" gene 396917..397762 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /label="yclE gene" CDS complement(397802..399280) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8458848, 11717292, 15849754, 16204487, 16850406, 17496096, 23144141, 25966844; Product type t: transporter" /codon_start=1 /transl_table=11 /product="di-tripeptide-proton ABC symporter" /protein_id="NP_388249.2" /db_xref="EnsemblGenomes-Gn:BSU03670" /db_xref="EnsemblGenomes-Tr:CAB12175" /db_xref="GOA:P94408" /db_xref="InterPro:IPR000109" /db_xref="InterPro:IPR005279" /db_xref="InterPro:IPR018456" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12027" /db_xref="UniProtKB/Swiss-Prot:P94408" /translation="MASIDNESIIKSVPQKGFFGHPRGLFTLFFTEFWERFSYYGMRA ILLYYLYTETVNGGLGFDKGTAVAIMSIYGSLVYMSTIIGGWLADRVFGTANTVFYGG IFIMFGHIALAYPGSSIAFYISMVLIIVGTGLLKPNVSSVVGDLYTKEDPRRDSGFSI FYMGINLGGLLAPLIVGTLGQKYNYHLGFGAAAVGMLLGLIVFALTRKKNLGLAGSNV PNPLSKKSAIGTGIGVIIVAIAVIISVQTGVLTIKRFIDLVSILGILIPVIYFIIMFT SKKADKTEKSRLAAYVPLFIGAVMFWAIQEQGATILAVYADERIRLSLGGFELQSSWF QSLNPLFVVIFAPIFAWLWMKLGKRQPSTPVKFSIGIILAGLSFIIMVFPAMQGKEAL VSPLWLVLSFLLVVLGELCLSPVGLSVTTKLAPAAFSAQTMSMWFLTNAAAQAINAQV AGLFDKIPETMYFGTIGLISIVLGGILLLLSPVIKRAMKGVL*" /label="dtpT CDS" gene complement(397802..399280) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /label="dtpT gene" downshifts complement(397810) /Source="Nicolas_upshifts" /id="D159" /incds=0 /nref=17 /ntot=90 /MaxReadThrough="1.40624" /MaxDrop="3.91827" /score="43.5753464" /energy="-21" /TU="NA" /idTUdmin="U281" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 399307..399309 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(399308..399327) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399318 /Source="Nicolas_upshifts" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 399326..399344 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(399328) /Source="Nicolas_upshifts" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(399330..399834) /Source="Nicolas_S_feature" /locus_tag="new_417763_418267_c" /HighExp="S3, S4, LoTm, S5, S6, T5.0H, T4.0H, M9-stat, S8, T3.30H" /AntisenseName="yclG" /AntisenseCor="0.33937447534762299" /AntisenseRegPval="-7.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S128" promotor_-35 complement(399342..399349) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 399498..399507 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 399520..399539 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399521 /Source="Nicolas_upshifts" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="upshifts" CDS 399560..401314 /gene="yclG" /locus_tag="BSU_03680" /old_locus_tag="BSU03680" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative uronase" /protein_id="NP_388250.1" /db_xref="EnsemblGenomes-Gn:BSU03680" /db_xref="EnsemblGenomes-Tr:CAB12176" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="InterPro:IPR024535" /db_xref="SubtiList:BG12028" /db_xref="UniProtKB/Swiss-Prot:P94409" /translation="MAEFILNAADFGVPRDGKTDSTERINQCLSTAVSKGYHTVWFPK GTYLIDATLGGDLNQRFRNAGIIVPGNLEIMMDPECIMKVIPNSSWGYSAFYVGKQEN ITISGGQIIGERDEHTYASAGIRSTHEWGFGICIEGCSNVVIDDVKISDFTGDGIIVS PRGLKTNQDYRTSEQIIIRRCEVRRSRRNNISITGCDMVTVEECLIEDAGTGNGTAPK FGIDIEGYGEGDVDYEEPINVSIRNNHFVGNVSSSVTNFNGYGILIEGNHSDNTISYG YGTQTVIKGNILRRPEDAAAAPRVGITGLGVSQGKETSDAVIAGNLITGFSTGIDVRG KSVLVTNNKISNFENTGILVYQSSDVKVDGNQIQNGLSETRRSIGLRAVLSDDIAFLN NCLIQVVDGVNVSGGNMIIKDNLLRKFSRGIWIAQGNAVIEGNTLNPDAFEAVPESYS VSVTNNAGAIIKNNTFKEFKNYPIYCSTSAKTSIIGNHLERSPLLVTIYISAGVHEIF DNTISVNRTAGNPIVIYLNGSAGSIISGNTINNLSAGTATAIQTNTSTNSKIIGNRIF KGTINKHSSDTIDGNMIV*" /label="yclG CDS" gene 399560..401314 /gene="yclG" /locus_tag="BSU_03680" /old_locus_tag="BSU03680" /label="yclG gene" promotor_-10 complement(399831..399849) /Source="Nicolas_upshift_promotors" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(399844) /Source="Nicolas_upshifts" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(399865..399870) /Source="Nicolas_upshift_promotors" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 401305 /Source="Nicolas_upshifts" /id="D160" /incds=0 /nref=6 /ntot=21 /MaxReadThrough="0.325519999999999" /MaxDrop="4.9689" /score="4.29139266" /energy="-5.4" /TU="NA" /idTUdmin="U282" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(401330..401551) /gene="yczF" /locus_tag="BSU_03690" /old_locus_tag="BSU03690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388251.1" /db_xref="EnsemblGenomes-Gn:BSU03690" /db_xref="EnsemblGenomes-Tr:CAB12177" /db_xref="GOA:O31479" /db_xref="SubtiList:BG12780" /db_xref="UniProtKB/Swiss-Prot:O31479" /translation="MKILGVTGFILICLLAISVLMDMLQGFSLTKAVYNNMSSFKMTT FAEWVVLLFFVLVLVREMYVIYKSKKKNP*" /label="yczF CDS" gene complement(401330..401551) /gene="yczF" /locus_tag="BSU_03690" /old_locus_tag="BSU03690" /label="yczF gene" promotor_-10 complement(401570..401581) /Source="Nicolas_upshift_promotors" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(401572) /Source="Nicolas_upshifts" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(401596..401602) /Source="Nicolas_upshift_promotors" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 401617..401623 /Source="Nicolas_upshift_promotors" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 401637..401648 /Source="Nicolas_upshift_promotors" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 401650 /Source="Nicolas_upshifts" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="upshifts" CDS 401677..403311 /gene="gerKA" /locus_tag="BSU_03700" /old_locus_tag="BSU03700" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 16707705, 16740944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 16707705, 16740944; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388252.1" /db_xref="EnsemblGenomes-Gn:BSU03700" /db_xref="EnsemblGenomes-Tr:CAB12178" /db_xref="GOA:P49939" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG11392" /db_xref="UniProtKB/Swiss-Prot:P49939" /translation="MPLFSKRKNNTDSKDKQNTDERNQEQQQEKERPVLISPSLAKNI AETKKEVGSSSDVIIREIKIGEQDHVHLAVIYISGLVDNNTIHESLIDPLVQDESIQN THAIQQILEKTLPLGGVKAEKSWDKLFSELMLGNALIFADGHDEALICSTQGGEQRSI QEPSTQVSFRGPRQGFTESLQTNISMIRRYIKNPNLWVEKMKKGSVTNTDIALMYIQG ICDEKVLKEVKQRLEKIDIDSILESGYIEQLIEDETFTTFPTMYHTERPDVVAGNLLE GRFAIIVDGTPFVLIAPALFVQFFQSVEDYYSRFDIATSIRILRVLVFFISLVAPAVY VAATTFHQEMIPTQLLVVIAAQREIVPFPAVVEALTMEVAFEILREAGVRLPRVVGSA VSIVGALVIGQAAVQAGIVSPAMVIIVALTAIASFATPAFAMAISARLIRFIFIIASA VMGFYGLILGIIMMFVHLCSLRSFGVPYMSPLAPFSSQGVKDALFRVPWWADEKRPES VSKEDKVRQGKDQRPEPAASRGMVNKDLEEGDQNGT*" /label="gerKA CDS" gene 401677..403311 /gene="gerKA" /locus_tag="BSU_03700" /old_locus_tag="BSU03700" /label="gerKA gene" CDS 403301..404524 /gene="gerKC" /locus_tag="BSU_03710" /old_locus_tag="BSU03710" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 16707705, 16740944, 19363077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 16707705, 16740944, 19363077; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388253.1" /db_xref="EnsemblGenomes-Gn:BSU03710" /db_xref="EnsemblGenomes-Tr:CAB12179" /db_xref="GOA:P49941" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG11394" /db_xref="UniProtKB/Swiss-Prot:P49941" /translation="MVRKCLLAVLMLLSVIVLPGCWDKRELTDLAIISAIGIDRTNDS NYVLHLQIINPGNVAGGLQGGGAGDRPPVSVYSIEGNNITEALRKASMKVSRRLYFAH TNLVVINEKLAKEEGLDFVLDNLDRDTEFRTTATFVVAHKTKAENIVKILTPIDKIPS NKVNKTLDFTEAQYGRVVKINIQDVLKTLAANTMAPVIPGYMMIGDDKKGVSMENTQA TDPKAILQADGLAVFDKAGYLKYWLEDDESVGAVWLMNKIQHTFINADWGKTKDAVSL QVTHQDTKLVPKMRNGRPYIHVKVSVEGIIDAVKYPFQLSDPKVLAAIEKALNKELEK EISHTVKKIKKNKIDFIGFGDTIYRKYPEQWEKMKDTWDKEYLPELPIDVKAETYIRR TGLRNNPIKHQFKDD*" /label="gerKC CDS" gene 403301..404524 /gene="gerKC" /locus_tag="BSU_03710" /old_locus_tag="BSU03710" /label="gerKC gene" CDS 404549..405670 /gene="gerKB" /locus_tag="BSU_03720" /old_locus_tag="BSU03720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 15849754, 16707705, 16740944, 16850406, 19363077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 15849754, 16707705, 16740944, 16850406, 19363077; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388254.1" /db_xref="EnsemblGenomes-Gn:BSU03720" /db_xref="EnsemblGenomes-Tr:CAB12180" /db_xref="GOA:P49940" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG11393" /db_xref="UniProtKB/Swiss-Prot:P49940" /translation="MEKARISIRQLFVMIIIFELGSSLLITPGSMAGRDAWIAVLLGC AIGLFLFYLYQGIYQCYPNSSPKEYMDDMLGTKLSWLFSFLYILYFAYIAARVLRDFG EMLLTFAYHDTPIIIVNALLMVVSIYAVRKGIEVLARAAELLFGAMYLLGAIGLVLII VSGTIDPHNLKPVLANGISPVLHSVFTQTMYVPFGEVVLFVMIFPNLNDRKDVKKMGM IAMAISGLIVALTVAINISVLDVDLTLRSQFPLLSTIQTIKVEEFLDRLDVFFMLALI IGGFFKVSLYLYATVVGTSTLFKEKNPSQLAYPMGLGILILSITIATNFSEHLNEGLN VVPLYIHLPFQLLFPLFLFIVAVWKKKRREKSKGEEAKK*" /label="gerKB CDS" gene 404549..405670 /gene="gerKB" /locus_tag="BSU_03720" /old_locus_tag="BSU03720" /label="gerKB gene" downshifts 405654 /Source="Nicolas_upshifts" /id="D161" /incds=0 /nref=6 /ntot=58 /MaxReadThrough="2.55658" /MaxDrop="3.73002" /score="3.39927899" /energy="-10.5" /TU="NA" /idTUdmin="U285" /TUdmin=2200 /isTUend="FALSE" /label="downshifts" CDS complement(405775..406455) /gene="yclH" /locus_tag="BSU_03730" /old_locus_tag="BSU03730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATPase component)" /protein_id="NP_388255.1" /db_xref="EnsemblGenomes-Gn:BSU03730" /db_xref="EnsemblGenomes-Tr:CAB12181" /db_xref="GOA:P94411" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12029" /db_xref="UniProtKB/Swiss-Prot:P94411" /translation="MSLLQFQQVGYWYKNKSQPLFQDINISFQKGKFYTIVGTSGTGK TTFLSLAGGLDAPKEGNILYDGKAVSKIGLTNFRNQYVSIVFQAYNLLPYMTALQNVT TAMEITGSKEKNKESYALDMLQKVGINEKQARQKVLTLSGGQQQRVSITRAFCCDTDL IVADEPTGNLDEDTSKEIVRLFQDLAHKEDKCVIMVTHDEQIAKVSDINIRLSRGSFT VKENVAVV*" /label="yclH CDS" gene complement(405775..406455) /gene="yclH" /locus_tag="BSU_03730" /old_locus_tag="BSU03730" /label="yclH gene" CDS complement(406471..407931) /gene="yclI" /locus_tag="BSU_03740" /old_locus_tag="BSU03740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388256.2" /db_xref="EnsemblGenomes-Gn:BSU03740" /db_xref="EnsemblGenomes-Tr:CAB12182" /db_xref="GOA:P94412" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG12030" /db_xref="UniProtKB/Swiss-Prot:P94412" /translation="MNFIKRAFWNMKAKKGKTLLQLFVFTVICVFVLSGLAIQSAAQK SSELARQELGGSVTLQVDRQKQMEKQQDSGEKRSFESTPIKVSDANKLAALDHVKSYN YTTSASANAGNFDAIESSSSSDSSSSSSSSNAKNSQGGGQGGPQMVQADLSIEGVIST ALVDDFSDGDSKITDGRAITKSDVGKKVTVINETLAEENDLSVGDSITIESATDEDTT VKLKIVGIYKTTSSGDDQAQNFSFLNPYNKLYTPYTATAALKGDDYKNTIDSAVYYMD DAKNMDTFVKAAKKTSIDFDTYTLNTNDQLYQQMVGPIENVASFSKNVVYLVSVAGAV ILGLIVMMSIRERKYEMGVLMAIGEKRWKLIGQFLTEILIVAVIAIGLASVTGNLVAN QLGNQLLSQQISSSTDSTQTASGQMPGGGGGMGGKMFGHSSSNVDVIDSLNVAVSMND MLILGGIGILIAIIATLLPSISVLRLHPKTILTKQE*" /label="yclI CDS" gene complement(406471..407931) /gene="yclI" /locus_tag="BSU_03740" /old_locus_tag="BSU03740" /label="yclI gene" misc_feature 408101..408120 /Source="Nicolas_upshift_promotors" /id="U286" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.647352647352647" /psig="0.962037962037962" /xcortree=1584 /SigmaFactorBS="tctagttgatgaaataaaaactaacaattgtgaaacgcaaaa ccttctgtttaaaatGGTGCTATTATATAAAAAAGcatcaaaacaaccggaggatata a" /listShort="yclJ, yclK, S129, rapC, phrC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 408104 /Source="Nicolas_upshifts" /id="U286" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.647352647352647" /psig="0.962037962037962" /xcortree=1584 /SigmaFactorBS="tctagttgatgaaataaaaactaacaattgtgaaacgcaaaa ccttctgtttaaaatGGTGCTATTATATAAAAAAGcatcaaaacaaccggaggatata a" /listShort="yclJ, yclK, S129, rapC, phrC" /GFF_Attribute="listLong" /label="upshifts" CDS 408144..408827 /gene="yclJ" /locus_tag="BSU_03750" /old_locus_tag="BSU03750" /function="16.10: Respire" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15375128, 20512483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15375128, 20512483; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YclK] (possibly involved in arabinogalactan metabolism)" /protein_id="NP_388257.1" /db_xref="EnsemblGenomes-Gn:BSU03750" /db_xref="EnsemblGenomes-Tr:CAB12183" /db_xref="GOA:P94413" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12031" /db_xref="UniProtKB/Swiss-Prot:P94413" /translation="MKILMIEDNVSVCTMTEMFFFKEGFEAEFVHDGLEGYQRFTEEN WDLIILDIMLPSMDGVTICRKIRETSTVPIIMLTAKDTESDQVIGFEMGADDYVTKPF SPLTLVARIKAVIRRYKATGKAVIDEDMIETECFTINKKTREVLLNGEPVENLTPKEF DLLYYLVQNPRQVFSREQLLEQVWGYQFYGDERTVDVHIKRLRKKLASEDKPFLYTVW GVGYKFDED*" /label="yclJ CDS" gene 408144..408827 /gene="yclJ" /locus_tag="BSU_03750" /old_locus_tag="BSU03750" /label="yclJ gene" CDS 408814..410235 /gene="yclK" /locus_tag="BSU_03760" /old_locus_tag="BSU03760" /function="16.3: Control" /function="16.10: Respire" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15375128, 20512483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15375128, 20512483; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YclJ]" /protein_id="NP_388258.1" /db_xref="EnsemblGenomes-Gn:BSU03760" /db_xref="EnsemblGenomes-Tr:CAB12184" /db_xref="GOA:P94414" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12032" /db_xref="UniProtKB/Swiss-Prot:P94414" /translation="MMKIKYLYQLLLSHISILILAFVIIISLFSHFVKEFAYQNKVEE LTSYAVQIANEFQSGQVDMRRLYPYQDILSTRKTQFIIFNEEQQPYFLPEGFHHPPRE QLKKSEWNKLKKGQTVTIRADGRFDDEVSLVAQPIFVQNEFKGAVLLISPISGVEQMV NQVNLYMFYAVISTLVITILVSWLLSKFHVKRIQKLREATDKVASGDYDIHLENSYGD EIGVLASDFNIMAKKLKQSRDEIERLEKRRRQFIADVSHELKTPLTTINGLVEGLNSH TIPEDKKDKCFSLISEETKRMLRLVKENLDYEKIRSQQITLNKLDVPLIEVFEIVKEH LQQQAEEKQNKLMIQVEDHVIVHADYDRFIQILVNITKNSIQFTQNGDIWLRGMEGYK ETIIEIEDTGIGIPKEDIEHIWERFYKADISRTNTAYGEYGLGLSIVRQLVEMHQGTV EIKSEEGKGTKFIIRLPLTAKQQ*" /label="yclK CDS" gene 408814..410235 /gene="yclK" /locus_tag="BSU_03760" /old_locus_tag="BSU03760" /label="yclK gene" downshifts 410211 /Source="Nicolas_upshifts" /id="D162" /incds=0 /nref=20 /ntot=169 /MaxReadThrough="3.43905" /MaxDrop="4.91565" /score="13.4599201" /energy="-15" /TU="U286" /idTUdmin="U286" /TUdmin="-1427" /isTUend="FALSE" /label="downshifts" S_feature 410256..410360 /Source="Nicolas_S_feature" /locus_tag="new_428689_428793" /HighExp="Lbstat, nit, ferm, BI, M0t45, M40t45, M0t90, S0, S2, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S129" misc_feature 410350..410369 /Source="Nicolas_upshift_promotors" /id="U287" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.986013986013986" /xcortree=678 /SigmaFactorBS="tcccgaaaacaaagattgcgtgtttttcgggttgggacggcc tataaaCATGATAAAATATGACATAAacagtttttgatgggagagggtgaaggaatga a" /listShort="rapC, phrC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 410362 /Source="Nicolas_upshifts" /id="U287" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.986013986013986" /xcortree=678 /SigmaFactorBS="tcccgaaaacaaagattgcgtgtttttcgggttgggacggcc tataaaCATGATAAAATATGACATAAacagtttttgatgggagagggtgaaggaatga a" /listShort="rapC, phrC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(410394) /Source="Nicolas_upshifts" /id="D163" /incds=0 /nref=2 /ntot=81 /MaxReadThrough="1.74985" /MaxDrop="4.10695" /score="1.47729412" /energy="-10.3" /TU="NA" /idTUdmin="U290" /TUdmin=1320 /isTUend="FALSE" /label="downshifts" CDS 410398..411546 /gene="rapC" /locus_tag="BSU_03770" /old_locus_tag="BSU03770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10464187, 12456319, 12897006, 12950917, 15968044, 19202088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464187, 12456319, 12897006, 12950917, 15968044, 19202088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388259.1" /db_xref="EnsemblGenomes-Gn:BSU03770" /db_xref="EnsemblGenomes-Tr:CAB12185" /db_xref="GOA:P94415" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11966" /db_xref="UniProtKB/Swiss-Prot:P94415" /translation="MKSGVIPSSAVGQKINEWYRYIRTFSVPDAEVLKAEIQQELKHM QHDSNLLLYYSLMEFRHQLMLDYLEPLEKLNIEDQPSLSELSRNIDSNQADLKGLLDY YVNFFRGMYEFDKREFISAITYYKQAEKKLSFVADHIERAEFYFKIAEAYYYMKQTYF SLINIKNAYEIYVEQETYNVRIIQCHFVFGVNLMDERNFEQAARHFKLALNMAQAEQK AQLVGRAYYNLGLCYYNQDLLDPAIDYFEKAVSTFESSRIVNSLPQAYFLITLIYYKQ GKHDKASEYHKRGYEYAKETDDADYAVKFEFLQSLYLDQPNEEGIERCFQYLKNKNMY ADIEDLALEVAKYYYEQKWFKLSASYFLQVEEARKQIQRSEGLYEIEI*" /label="rapC CDS" gene 410398..411546 /gene="rapC" /locus_tag="BSU_03770" /old_locus_tag="BSU03770" /label="rapC gene" promotor_-35 411246..411251 /Source="Nicolas_upshift_promotors" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 411264 /Source="Nicolas_upshifts" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 411268..411286 /Source="Nicolas_upshift_promotors" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 411408..411416 /Source="Nicolas_upshift_promotors" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 411428..411446 /Source="Nicolas_upshift_promotors" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 411440 /Source="Nicolas_upshifts" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="upshifts" CDS 411530..411652 /gene="phrC" /locus_tag="BSU_03780" /old_locus_tag="BSU03780" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464187, 12456319, 12897006, 12950917, 16816200, 19202088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464187, 12456319, 12897006, 12950917, 16816200, 19202088; Product type r : regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapC and competence and sporulation stimulating factor (CSF)" /protein_id="NP_388260.1" /db_xref="EnsemblGenomes-Gn:BSU03780" /db_xref="EnsemblGenomes-Tr:CAB12186" /db_xref="GOA:P94416" /db_xref="InterPro:IPR020243" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11959" /db_xref="UniProtKB/Swiss-Prot:P94416" /translation="MKLKSKLFVICLAAAAIFTAAGVSANAEALDFHVTERGMT*" /label="phrC CDS" gene 411530..411652 /gene="phrC" /locus_tag="BSU_03780" /old_locus_tag="BSU03780" /label="phrC gene" downshifts 411639 /Source="Nicolas_upshifts" /id="D164" /incds=0 /nref=260 /ntot=275 /MaxReadThrough="3.24518" /MaxDrop="7.70367" /score="26.3182765" /energy="-14" /TU="NA" /idTUdmin="U286" /TUdmin=1 /isTUend="TRUE" /label="downshifts" downshifts complement(411707) /Source="Nicolas_upshifts" /id="D165" /incds=0 /nref=3 /ntot=64 /MaxReadThrough="0.60499" /MaxDrop="7.4475" /score="-1.25354129" /energy="-15.8" /TU="NA" /idTUdmin="U290" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(411752..411841) /gene="yczM" /locus_tag="BSU_03788" /old_locus_tag="BSU03788" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097676.1" /db_xref="EnsemblGenomes-Gn:BSU03788" /db_xref="EnsemblGenomes-Tr:CAX52547" /db_xref="GOA:C0H3V0" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3V0" /translation="MSGYGTSFALIVVLFILLIIVGTAFVGGY*" /label="yczM CDS" gene complement(411752..411841) /gene="yczM" /locus_tag="BSU_03788" /old_locus_tag="BSU03788" /label="yczM gene" downshifts complement(411912) /Source="Nicolas_upshifts" /id="D166" /incds=0 /nref=25 /ntot=113 /MaxReadThrough="7.05273" /MaxDrop="3.3619" /score="32.1465401" /energy="-16.5" /TU="U290" /idTUdmin="U290" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS complement(411923..412036) /gene="yczN" /locus_tag="BSU_03789" /old_locus_tag="BSU03789" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore and germination protein" /protein_id="YP_003097677.1" /db_xref="EnsemblGenomes-Gn:BSU03789" /db_xref="EnsemblGenomes-Tr:CAX52548" /db_xref="GOA:C0H3V1" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3V1" /translation="MSGYSNGGGYGGISSFALIVVLFILLIIVGTAFVGGF*" /label="yczN CDS" gene complement(411923..412036) /gene="yczN" /locus_tag="BSU_03789" /old_locus_tag="BSU03789" /label="yczN gene" promotor_-10 complement(412057..412076) /Source="Nicolas_upshift_promotors" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(412068) /Source="Nicolas_upshifts" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(412089..412098) /Source="Nicolas_upshift_promotors" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(412190..413554) /gene="thrD" /locus_tag="BSU_03790" /old_locus_tag="BSU03790" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2152900, 11471740, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2152900, 11471740, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate kinase III" /protein_id="NP_388261.1" /db_xref="EnsemblGenomes-Gn:BSU03790" /db_xref="EnsemblGenomes-Tr:CAB12187" /db_xref="GOA:P94417" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR035804" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12033" /db_xref="UniProtKB/Swiss-Prot:P94417" /translation="MKVVKFGGSSLASGAQLDKVFHIVTSDPARKAVVVSAPGKHYAE DTKVTDLLIACAEQYLATGSAPELAEAVVERYALIANELQLGQSIIEKIRDDLFTLLE GDKSNPEQYLDAVKASGEDNNAKLIAAYFRYKGVKAEYVNPKDAGLFVTNEPGNAQVL PESYQNLYRLRERDGLIIFPGFFGFSKDGDVITFSRSGSDITGSILANGLQADLYENF TDVDAVYSVNPSFVENPKEISELTYREMRELSYAGFSVFHDEALIPAFRAGIPVQIKN TNNPSAEGTRVVSKRDNTNGPVVGIASDTGFCSIYISKYLMNREIGFGRRALQILEEH GLTYEHVPSGIDDMTIILRQGQMDAATERSVIKRIEEDLHADEVIVEHHLALIMVVGE AMRHNVGTTARAAKALSEAQVNIEMINQGSSEVSMMFGVKEAEERKAVQALYQEFFAG VLIS*" /label="thrD CDS" gene complement(412190..413554) /gene="thrD" /locus_tag="BSU_03790" /old_locus_tag="BSU03790" /label="thrD gene" downshifts complement(412198) /Source="Nicolas_upshifts" /id="D167" /incds=0 /nref=23 /ntot=129 /MaxReadThrough="2.21842" /MaxDrop="4.81019" /score="44.9085917" /energy="-15" /TU="NA" /idTUdmin="U291" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(412242) /Source="Nicolas_upshifts" /id="D168" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="5.53807" /MaxDrop="2.54279" /score="44.9085917" /energy="-15" /TU="U291" /idTUdmin="U291" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(413590..413609) /Source="Nicolas_upshift_promotors" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(413606) /Source="Nicolas_upshifts" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(413624..413631) /Source="Nicolas_upshift_promotors" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 413745..413749 /Source="Nicolas_upshift_promotors" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 413765..413784 /Source="Nicolas_upshift_promotors" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 413777 /Source="Nicolas_upshifts" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 413808..413815 /Source="Nicolas_upshift_promotors" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 413829..413848 /Source="Nicolas_upshift_promotors" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 413838..413938 /Source="Nicolas_S_feature" /locus_tag="new_432271_432371" /HighExp="LBGexp, Lbexp, G150, dia0, G135, H2O2, Paraq, dia15, G180, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S130" upshifts 413838 /Source="Nicolas_upshifts" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="upshifts" CDS 413939..414889 /gene="pbtN" /locus_tag="BSU_03800" /old_locus_tag="BSU03800" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (permease)" /protein_id="NP_388262.1" /db_xref="EnsemblGenomes-Gn:BSU03800" /db_xref="EnsemblGenomes-Tr:CAB12188" /db_xref="GOA:P94418" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12034" /db_xref="UniProtKB/Swiss-Prot:P94418" /translation="MKLRYLFILLIILAVTSVFIGVEDLSPLDLFDLSKQEASTLFAS RLPRLISIVIAGLSMSICGLIMQQISRNKFVSPTTAGTMDWARLGILISLLLFTSASP LIKMLVAFVFALAGNFLFMKILERIKFNDTIFIPLVGLMLGNIVSSIATFIAYKYDLI QNVSSWLQGDFSLVVKGRYELLYLSIPLVIIAYVYADKFTLAGMGESFSVNLGLKYKR VVNIGLIIVSLITSLVILTVGMLPFLGLIIPNIVSIYRGDNLKSSLPHTVLLGAVFVL FCDILGRIIIFPYEISIGLMVGIIGSGIFLFMLLRRKAYA*" /label="pbtN CDS" gene 413939..414889 /gene="pbtN" /locus_tag="BSU_03800" /old_locus_tag="BSU03800" /label="pbtN gene" CDS 414882..415829 /gene="pbtO" /locus_tag="BSU_03810" /old_locus_tag="BSU03810" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (permease)" /protein_id="NP_388263.1" /db_xref="EnsemblGenomes-Gn:BSU03810" /db_xref="EnsemblGenomes-Tr:CAB12189" /db_xref="GOA:P94419" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12035" /db_xref="UniProtKB/Swiss-Prot:P94419" /translation="MRNQMKIALLVGLAIVCIGLFLFYDLGNWDYTLPRRIKKVAAIV LTGGAIAFSTMIFQTITNNRILTPSILGLDSLYMLIQTGIIFLFGSANMVIMNKNINF IISVLLMILFSLVLYQIMFKGEGRNIFFLLLIGIVFGTLFSSLSSFMQMLIDPNEFQV VQDKMFASFNNINTDLLWLAFIIFLLTGVYVWRFTKFFDVLSLGREHAVNLGIDYDKV VKQMLIVVAILVSVSTALVGPIMFLGLLVVNLAREFLKTYKHSYLIAGSVFISIIALV GGQFVVEKVFTFSTTLSVIINFAGGIYFIYLLLKENKSW*" /label="pbtO CDS" gene 414882..415829 /gene="pbtO" /locus_tag="BSU_03810" /old_locus_tag="BSU03810" /label="pbtO gene" CDS 415823..416581 /gene="pbtP" /locus_tag="BSU_03820" /old_locus_tag="BSU03820" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (ATP-binding protein)" /protein_id="NP_388264.1" /db_xref="EnsemblGenomes-Gn:BSU03820" /db_xref="EnsemblGenomes-Tr:CAB12190" /db_xref="GOA:P94420" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12036" /db_xref="UniProtKB/Swiss-Prot:P94420" /translation="MVEVRNVSKQYGGKVVLEETSVTIQKGKITSFIGPNGAGKSTLL SIMSRLIKKDSGEIYIDGQEIGACDSKELAKKMSILKQANQINIRLTIKDLVSFGRFP YSQGRLTEEDWVHINQALSYMKLEDIQDKYLDQLSGGQCQRAFIAMVIAQDTDYIFLD EPLNNLDMKHSVEIMKLLKRLVEELGKTIVIVIHDINFASVYSDYIVALKNGRIVKEG PPEEMIETSVLEEIYDMTIPIQTIDNQRIGVYFS*" /label="pbtP CDS" gene 415823..416581 /gene="pbtP" /locus_tag="BSU_03820" /old_locus_tag="BSU03820" /label="pbtP gene" CDS 416603..417556 /gene="pbtQ" /locus_tag="BSU_03830" /old_locus_tag="BSU03830" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 19955416, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 19955416, 25355936; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (binding lipoprotein)" /protein_id="NP_388265.1" /db_xref="EnsemblGenomes-Gn:BSU03830" /db_xref="EnsemblGenomes-Tr:CAB12191" /db_xref="GOA:P94421" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR033870" /db_xref="PDB:3GFV" /db_xref="SubtiList:BG12037" /db_xref="UniProtKB/Swiss-Prot:P94421" /translation="MKKFALLFIALVTAVVISACGNQSTSSKGSDTKKEQITVKHQLD KNGTKVPKNPKKVVVFDFGSLDTLDKLGLDDIVAGLPKQVLPKYLSKFKDDKYADVGS LKEPDFDKVAELDPDLIIISARQSESYKEFSKIAPTIYLGVDTAKYMESFKSDAETIG KIFDKEDKVKDELANIDHSIADVKKTAEKLNKNGLVIMANDGKISAFGPKSRYGLIHD VFGVAPADQNIKASTHGQSVSYEYISKTNPDYLFVIDRGTAIGETSSTKQVVENDYVK NVNAVKNGHVIYLDSATWYLSGGGLESMTQMIKEVKDGLEK*" /label="pbtQ CDS" gene 416603..417556 /gene="pbtQ" /locus_tag="BSU_03830" /old_locus_tag="BSU03830" /label="pbtQ gene" downshifts 417539 /Source="Nicolas_upshifts" /id="D169" /incds=0 /nref=161 /ntot=280 /MaxReadThrough="3.87669" /MaxDrop="7.4722" /score="31.9942335" /energy="-13.8" /TU="U293" /idTUdmin="U292" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(417603..419021) /gene="ycnB" /locus_tag="BSU_03840" /old_locus_tag="BSU03840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15855514, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388266.1" /db_xref="EnsemblGenomes-Gn:BSU03840" /db_xref="EnsemblGenomes-Tr:CAB12192" /db_xref="GOA:P94422" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12038" /db_xref="UniProtKB/Swiss-Prot:P94422" /translation="MNTSIEQKPFNRSVIVGILLAGAFVAILNQTLLITALPHIMRDF NVDANQAQWLTTSFMLTNGILIPITAFLIEKFTSRALLITAMSIFTAGTVVGAFAPNF PVLLTARIIQAAGAGIMMPLMQTVFLTIFPIEKRGQAMGMVGLVISFAPAIGPTLSGW AVEAFSWRSLFYIILPFAVIDLILASILMKNVTTLRKTQIDILSVILSTFGFGGLLYG FSSVGSYGWSSSTVLISLLVGVIALLLFITRQMKLKKPMLEFRVFTFGVFSLTTLLGT LVFALLIGTETILPLYTQNVRDVTAFDTGLMLLPGAVVMGFMSPIIGRIFDRVGGRGL AIAGFCIIFLTSLPFMQLTDHTSLAWIVVLYTVRLLGTAMIMMPVTTAGINALPRHLI PHGTAMNNTIRQVGGSIGTALLVSVMSNQAAHAGTTNVKHAALHGMNAAFIVAAVIAL VGFLLSFTLKKPQRPAEQQPAR*" /label="ycnB CDS" gene complement(417603..419021) /gene="ycnB" /locus_tag="BSU_03840" /old_locus_tag="BSU03840" /label="ycnB gene" downshifts complement(417624) /Source="Nicolas_upshifts" /id="D170" /incds=0 /nref=8 /ntot=150 /MaxReadThrough="2.00954" /MaxDrop="5.13029" /score="17.5501827" /energy="-13.8" /TU="NA" /idTUdmin="U294" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(419041..419919) /gene="ycnC" /locus_tag="BSU_03850" /old_locus_tag="BSU03850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388267.2" /db_xref="EnsemblGenomes-Gn:BSU03850" /db_xref="EnsemblGenomes-Tr:CAB12193" /db_xref="GOA:P94423" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12039" /db_xref="UniProtKB/Swiss-Prot:P94423" /translation="MLDKKTDILLAARKLFSEKDFTSVSMQAIAEECKMSKASIYKLF QSKEDLLLELLSFNQKQMVAAASRLQENTALTPEERLTQKVKMELEGFRRNQQFFNML TYGNPKLHNDRVKQHIHQTRSTIICWHRDSLIQAYGETILPFVWDLVIILHGMMREFL MLIKIEEKPLELDPIAEFIISTLNQIIKNRETRQSLLPPEAIELYIHSASSYKPKDKS VLLSESLKELHKGISSLSAADYDVDELTSAAAMLEEEAKKEEPRAFLLKSLIGYLEQT GVLTQPVSMLKTLLIT*" /label="ycnC CDS" gene complement(419041..419919) /gene="ycnC" /locus_tag="BSU_03850" /old_locus_tag="BSU03850" /label="ycnC gene" S_feature complement(419920..419986) /Source="Nicolas_S_feature" /locus_tag="new_438353_438419_c" /HighExp="dia15, H2O2, Diami, Paraq, Oxctl, Cold, G180, Salt, BMM, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S131" promotor_-10 complement(419985..420004) /Source="Nicolas_upshift_promotors" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(419994) /Source="Nicolas_upshifts" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(420019..420025) /Source="Nicolas_upshift_promotors" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(420083..420832) /gene="nfrAB" /locus_tag="BSU_03860" /old_locus_tag="BSU03860" /EC_number="1.5.1.39" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16229462, 9836433, 20862523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16229462, 9836433, 20862523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-FMN oxidoreductase (nitroreductase)" /protein_id="NP_388268.1" /db_xref="EnsemblGenomes-Gn:BSU03860" /db_xref="EnsemblGenomes-Tr:CAB12194" /db_xref="GOA:P94424" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:1ZCH" /db_xref="SubtiList:BG12040" /db_xref="UniProtKB/Swiss-Prot:P94424" /translation="MNEVIKSLTDHRSIRSYTDEPVAQEQLDQIIEAVQSAPSSINGQ QVTVITVQDKERKKKISELAGGQPWIDQAPVFLLFCADFNRAKIALEDLHDFKMEITN GLESVLVGAVDAGIALGTATAAAESLGLGTVPIGAVRGNPQELIELLELPKYVFPLSG LVIGHPADRSAKKPRLPQEAVNHQETYLNQDELTSHIQAYDEQMSEYMNKRTNGKETR NWSQSIASYYERLYYPHIREMLEKQGFKVEK*" /label="nfrAB CDS" gene complement(420083..420832) /gene="nfrAB" /locus_tag="BSU_03860" /old_locus_tag="BSU03860" /label="nfrAB gene" downshifts complement(420096) /Source="Nicolas_upshifts" /id="D171" /incds=0 /nref=136 /ntot=243 /MaxReadThrough="2.08639" /MaxDrop="5.10745" /score="11.1864402" /energy="-18.6" /TU="NA" /idTUdmin="U296" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(420849..421136) /gene="ycnE" /locus_tag="BSU_03870" /old_locus_tag="BSU03870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17274596, 21454635; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AI-2 degrading enzyme" /protein_id="NP_388269.1" /db_xref="EnsemblGenomes-Gn:BSU03870" /db_xref="EnsemblGenomes-Tr:CAB12195" /db_xref="GOA:P94425" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12041" /db_xref="UniProtKB/Swiss-Prot:P94425" /translation="MIVLQAYIKVKPEKREEFLSEAQSLVQHSRAEEGNAQYDLFEKV GEENTFVMLEKWKDEAAMKFHNETAHFQGFVAKGKELLSAPLDVVRTELSE*" /label="ycnE CDS" gene complement(420849..421136) /gene="ycnE" /locus_tag="BSU_03870" /old_locus_tag="BSU03870" /label="ycnE gene" promotor_-35 421102..421109 /Source="Nicolas_upshift_promotors" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 421123..421142 /Source="Nicolas_upshift_promotors" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 421142 /Source="Nicolas_upshifts" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(421180..421199) /Source="Nicolas_upshift_promotors" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(421196) /Source="Nicolas_upshifts" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(421213..421220) /Source="Nicolas_upshift_promotors" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 421241..421248 /Source="Nicolas_upshift_promotors" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 421253 /Source="Nicolas_upshifts" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 421259..421278 /Source="Nicolas_upshift_promotors" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 421276..421590 /gene="yczG" /locus_tag="BSU_03880" /old_locus_tag="BSU03880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388270.1" /db_xref="EnsemblGenomes-Gn:BSU03880" /db_xref="EnsemblGenomes-Tr:CAB12196" /db_xref="GOA:O31480" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12781" /db_xref="UniProtKB/Swiss-Prot:O31480" /translation="MNIPNHPETETLQLTKVLHALSDPLRLELVKQLAEAKEKTCSTC ADVQVAKSTLSHHFKVLRESGIAQVRIEGKRRYYSLRAEDLEKAFPGLLEAVLNVDQD RW*" /label="yczG CDS" gene 421276..421590 /gene="yczG" /locus_tag="BSU_03880" /old_locus_tag="BSU03880" /label="yczG gene" downshifts 421582 /Source="Nicolas_upshifts" /id="D172" /incds=0 /nref=173 /ntot=262 /MaxReadThrough="0.52252" /MaxDrop="5.32898" /score="20.7855667" /energy="-7.4" /TU="NA" /idTUdmin="U297" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(421592..423031) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /experiment="publication(s) with functional evidences, PMID:15223311, 24127574, 25388514, 27640111, 28348215, 28412355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223311, 24127574, 25388514, 27640111, 28348215, 28412355; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR/MocR family) with PLP binding site (GabR-GABA-PLP aldimine)" /protein_id="NP_388271.1" /db_xref="EnsemblGenomes-Gn:BSU03890" /db_xref="EnsemblGenomes-Tr:CAB12197" /db_xref="GOA:P94426" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4MGR" /db_xref="PDB:4N0B" /db_xref="PDB:4TV7" /db_xref="PDB:5T4J" /db_xref="PDB:5T4K" /db_xref="PDB:5X03" /db_xref="SubtiList:BG12042" /db_xref="UniProtKB/Swiss-Prot:P94426" /translation="MDITITLDRSEQADYIYQQIYQKLKKEILSRNLLPHSKVPSKRE LAENLKVSVNSVNSAYQQLLAEGYLYAIERKGFFVEELDMFSAEEHPPFALPDDLKEI HIDQSDWISFSHMSSDTDHFPIKSWFRCEQKAASRSYRTLGDMSHPQGIYEVRAAITR LISLTRGVKCRPEQMIIGAGTQVLMQLLTELLPKEAVYAMEEPGYRRMYQLLKNAGKQ VKTIMLDEKGMSIAEITRQQPDVLVTTPSHQFPSGTIMPVSRRIQLLNWAAEEPRRYI IEDDYDSEFTYDVDSIPALQSLDRFQNVIYMGTFSKSLLPGLRISYMVLPPELLRAYK QRGYDLQTCSSLTQLTLQEFIESGEYQKHIKKMKQHYKEKRERLITALEAEFSGEVTV KGANAGLHFVTEFDTRRTEQDILSHAAGLQLEIFGMSRFNLKENKRQTGRPALIIGFA RLKEEDIQEGVQRLFKAVYGHKKIPVTGD*" /label="gabR CDS" gene complement(421592..423031) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /label="gabR gene" promotor_-10 complement(421916..421927) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(421922) /Source="Nicolas_upshifts" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(421941..421947) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(423074..423093) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 423075..423082 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(423081) /Source="Nicolas_upshifts" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 423096..423115 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 423100 /Source="Nicolas_upshifts" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(423104..423111) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 423138..424448 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /EC_number="2.6.1.19" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-aminobutyrate aminotransferase" /protein_id="NP_388272.1" /db_xref="EnsemblGenomes-Gn:BSU03900" /db_xref="EnsemblGenomes-Tr:CAB12198" /db_xref="GOA:P94427" /db_xref="InterPro:IPR004632" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12043" /db_xref="UniProtKB/Swiss-Prot:P94427" /translation="MSQTTASITTAQWQQKRDQFVSKGVSNGNRSLAVKGEGAELYDL DGRRFIDFAGAIGTLNVGHSHPKVVEAVKRQAEELIHPGFNVMMYPTYIELAEKLCGI APGSHEKKAIFLNSGAEAVENAVKIARKYTKRQGVVSFTRGFHGRTNMTMSMTSKVKP YKFGFGPFAPEVYQAPFPYYYQKPAGMSDESYDDMVIQAFNDFFIASVAPETVACVVM EPVQGEGGFIIPSKRFVQHVASFCKEHGIVFVADEIQTGFARTGTYFAIEHFDVVPDL ITVSKSLAAGLPLSGVIGRAEMLDAAAPGELGGTYAGSPLGCAAALAVLDIIEEEGLN ERSEEIGKIIEDKAYEWKQEFPFIGDIRRLGAMAAIEIVKDPDTREPDKTKAAAIAAY ANQNGLLLLTAGINGNIIRFLTPLVISDSLLNEGLSILEAGLRA*" /label="gabT CDS" gene 423138..424448 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /label="gabT gene" promotor_-35 424326..424332 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424346..424364 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 424354 /Source="Nicolas_upshifts" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 424450..424457 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424472..424491 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 424481 /Source="Nicolas_upshifts" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" CDS 424517..425905 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /EC_number="1.2.1.24" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate-semialdehyde dehydrogenase" /protein_id="NP_388273.1" /db_xref="EnsemblGenomes-Gn:BSU03910" /db_xref="EnsemblGenomes-Tr:CAB12199" /db_xref="GOA:P94428" /db_xref="InterPro:IPR010102" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="SubtiList:BG12044" /db_xref="UniProtKB/Swiss-Prot:P94428" /translation="MPDQLTVYNPATGEEIKTIPQQSATEVEEAIERSHQAFKTWSKT SANERTSLLKKWYELIVEHKEELADLITKENGKPYQEAVGEVLYGAGYIEWFAEEAKR VYGRTVPAPTTGKRIVVTRQPVGPVAAITPWNFPNAMITRKAAPALAAGCTFIIKPAP DTPLSAYELARLAYEAGIPKDVLQVVIGDGEEIGNVFTSSPKIRKITFTGSTPVGKIL MKNSADTVKHVSMELGGHAPLIVDEDADIDLAVEQAMASKYRNAGQTCVCANRLIVHE SIKDEFAAKLSEQVSKLKVGNGLEEGVNVGPIINKRGFEKIVSQIDDAVEKGAKVIAG GTYDRNDDKGCYFVNPTVLTDVDTSMNIMHEETFGPVAPIVTFSDIDEAIQLANDTPY GLAAYFFTENYRRGIYISENLEYGIIGWNDGGPSAVQAPFGGMKESGIGREGGSEGIE PYLETKYLSIGL*" /label="gabD CDS" gene 424517..425905 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /label="gabD gene" downshifts 425913 /Source="Nicolas_upshifts" /id="D173" /incds=0 /nref=107 /ntot=240 /MaxReadThrough="0.105510000000001" /MaxDrop="6.52053" /score="38.677658" /energy="-19.9" /TU="NA" /idTUdmin="U301" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 425963..425969 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 425983..425994 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 425984 /Source="Nicolas_upshifts" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="upshifts" CDS 426028..426891 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438764, 15849754, 16850406, 19054326, 21564334, 27329749; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose uptake protein" /protein_id="NP_388274.1" /db_xref="EnsemblGenomes-Gn:BSU03920" /db_xref="EnsemblGenomes-Tr:CAB12200" /db_xref="GOA:P40420" /db_xref="InterPro:IPR010651" /db_xref="SubtiList:BG11066" /db_xref="UniProtKB/Swiss-Prot:P40420" /translation="MDLLLALLPALFWGSIVLFNVKLGGGPYSQTLGTTIGALIVSIV IYFFVQPVLSLRIFIVGIVSGLFWSLGQANQLKSIQLMGVSKTMPISTGMQLVSTSLF GVIVFREWSTPIAITLGVLALIFIIVGIILTSLEDKNDKKEGEPSNLKKGILILLVST LGYLVYVVVARLFNVSGWSALLPQAIGMVVGGLVLTYRHKPFNKYAIRNILPGLIWAG GNMFLFISQPRVGVATSFSLSQMGIVISTLGGIFILREKKTKRQLIAIAIGIILIIAA AVFLGIAKTNS*" /label="glcU CDS" gene 426028..426891 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /label="glcU gene" CDS 426911..427696 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /EC_number="1.1.1.47" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2493633, 3141376, 6438057, 16912926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2493633, 3141376, 6438057, 16912926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="forespore glucose 1-dehydrogenase" /protein_id="NP_388275.1" /db_xref="EnsemblGenomes-Gn:BSU03930" /db_xref="EnsemblGenomes-Tr:CAB12201" /db_xref="GOA:P12310" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10545" /db_xref="UniProtKB/Swiss-Prot:P12310" /translation="MYPDLKGKVVAITGAASGLGKAMAIRFGKEQAKVVINYYSNKQD PNEVKEEVIKAGGEAVVVQGDVTKEEDVKNIVQTAIKEFGTLDIMINNAGLENPVPSH EMPLKDWDKVIGTNLTGAFLGSREAIKYFVENDIKGNVINMSSVHEVIPWPLFVHYAA SKGGIKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKFADPKQKADVESMIPMGYI GEPEEIAAVAAWLASKEASYVTGITLFADGGMTQYPSFQAGRG*" /label="gdh CDS" gene 426911..427696 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /label="gdh gene" misc_feature 427016..427035 /Source="Nicolas_upshift_promotors" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 427016 /Source="Nicolas_upshifts" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 427104 /Source="Nicolas_upshifts" /id="D174" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.44884" /MaxDrop="2.47712" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U301" /TUdmin=1188 /isTUend="FALSE" /label="downshifts" downshifts 427698 /Source="Nicolas_upshifts" /id="D175" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="2.7861" /MaxDrop="4.2307" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U303" /TUdmin="-836" /isTUend="FALSE" /label="downshifts" CDS complement(427741..428355) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19168619, 22904286, 27010565, 26822828; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative membrane protein involved in copper intake" /protein_id="NP_388276.1" /db_xref="EnsemblGenomes-Gn:BSU03940" /db_xref="EnsemblGenomes-Tr:CAB12202" /db_xref="GOA:P94431" /db_xref="InterPro:IPR012533" /db_xref="SubtiList:BG12045" /db_xref="UniProtKB/Swiss-Prot:P94431" /translation="MLKKIALTLCPAIVGSLLFFTAPASAHVSVKPAESAAGSWETYT MKVPSEKNLPTTKVVLKMPKDVEFQQYEPIPGWKVSTQKHDDKSVSVTWEATDGGIQE GQFQQFTFVAKNPDKAEEAAWDAYQYYKDGSIVEWTGDEDADTPHSITNITSAKQVTD EHGATKTEDDSENSGSSALDITAMVLSAAAIILSVAALVKKKRA*" /label="cutI CDS" gene complement(427741..428355) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /label="cutI gene" downshifts complement(427752) /Source="Nicolas_upshifts" /id="D176" /incds=0 /nref=95 /ntot=219 /MaxReadThrough="0.879290000000001" /MaxDrop="6.67627" /score="21.5633403" /energy="-16" /TU="NA" /idTUdmin="U305" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(428368..429993) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15101989, 15849754, 16850406, 19168619, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 15849754, 16850406, 19168619, 22904286, 23012364; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper import permease subunit" /protein_id="NP_388277.2" /db_xref="EnsemblGenomes-Gn:BSU03950" /db_xref="EnsemblGenomes-Tr:CAB12203" /db_xref="GOA:C0SP95" /db_xref="InterPro:IPR007348" /db_xref="InterPro:IPR008457" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR032693" /db_xref="InterPro:IPR032694" /db_xref="SubtiList:BG12046" /db_xref="UniProtKB/Swiss-Prot:C0SP95" /translation="MKRNRWWIILLLFLVFLPKTSFAHAYIVKSSPGENSELKSAPAQ VEIEFNEPVEEGFHYIKVYNSNGDRVDTDKTEIKKDNHHIMTVKLKKNLPKDVYRAEW NAVSADGHPVSGVIPFSIGKADGGFSSQKAADSALNPGTAADRAILYTALSLFIGTVF FHLFWYKGKSEQLVKRTRRILTGSIAALGLALLLQLPIQTKANAGGGWGSAFQPGYIR ETLFETAGGSIWIIQAALFVLLALSVIPAIRKNRFSSFGYWTAPLIFFFGLLLAKAFT GHAAVVEEKTVGILMDFLHLTSASIWVGGIAALVLLLSKEWRQPDKTLAWETVRRFSP WALTAVGVILFSGLLNGFFIIRSMDSLFHTAYGQALLVKSGLFVFMLVLGAIHFLLTR KQRRTGISRTLKAEWAIGIAVLITAAVFTSLPSPPEPAPEPFYQTKAIENGQSVSLSI SPNQPGKNVFELRVTDHNGDPVKNIQQITLTVYKTGLSGSENKSTFTLKEKTKGVFQD QNLSINEKGNWKIKVHGLTGDFNEINIMFTKTN*" /label="cutJ CDS" gene complement(428368..429993) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /label="cutJ gene" CDS complement(430028..430600) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 22904286, 23012364; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of copper intake (CutR-Cu(+))" /protein_id="NP_388278.1" /db_xref="EnsemblGenomes-Gn:BSU03960" /db_xref="EnsemblGenomes-Tr:CAB12204" /db_xref="GOA:P94433" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR008719" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12047" /db_xref="UniProtKB/Swiss-Prot:P94433" /translation="MLPINRQQHILKWLKEEGSLRISDISARFGVSEMTVYRDVNQLV QSNQVIKTAGGITLPVRTPQTDHMCSYCLKPVNQAHSVQLITVNQDIEQLCCAHCAFL RYADKTEEVSHLICRDFLLQTTVSAGSAYFVVNAELNLHCCQPQAIPFATLDHAERFQ KGFGGAVCTFDQALEDMLQDRKKRCTCTKK*" /label="cutR CDS" gene complement(430028..430600) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /label="cutR gene" promotor_-10 complement(430622..430641) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(430637) /Source="Nicolas_upshifts" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(430655..430662) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 430722..430741 /Source="Nicolas_upshift_promotors" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 430734 /Source="Nicolas_upshifts" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="upshifts" CDS 430765..431118 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18307109, 27010565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative reductase or disulfide isomerase" /protein_id="NP_388279.1" /db_xref="EnsemblGenomes-Gn:BSU03970" /db_xref="EnsemblGenomes-Tr:CAB12205" /db_xref="GOA:P94434" /db_xref="SubtiList:BG12048" /db_xref="UniProtKB/Swiss-Prot:P94434" /translation="MKETPCPNCGKPLTGDMVRSSNVPCQFRCGHCRERLYEYKVSAP IMLVSLAAIVLLIYLLMLLRNAAGSVLPAVQHVPMAVFALVCAYPVFIVSERMIAKYV IQNGNIIYRGKRKGS*" /label="ycnL CDS" gene 430765..431118 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /label="ycnL gene" downshifts 431089 /Source="Nicolas_upshifts" /id="D177" /incds=0 /nref=136 /ntot=248 /MaxReadThrough="0.860829999999999" /MaxDrop="6.25982" /score="38.4886131" /energy="-13.4" /TU="NA" /idTUdmin="U306" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 431182..431189 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 431203..431222 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 431208 /Source="Nicolas_upshifts" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="upshifts" S_feature 431218..431290 /Source="Nicolas_S_feature" /locus_tag="new_449651_449723" /HighExp="S0, dia5, Gly, G135, B60, T0.30H, BT, G180, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S132" CDS 431291..432727 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IICB component" /protein_id="NP_388280.2" /db_xref="EnsemblGenomes-Gn:BSU03981" /db_xref="EnsemblGenomes-Tr:CAB12206" /db_xref="GOA:P42956" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004718" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR029503" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11215" /db_xref="UniProtKB/Swiss-Prot:P42956" /translation="MQQQEQQQGGMKVKVQRFGSYLSGMIMPNIGAFIAWGIITALFI PAGWFPNEQLNTLVSPMITYLLPLLIAYTGGKMIYDHRGGVVGATAAIGVIVGSDIPM FLGAMIMGPLGGYLIKQTDKLFKDKVKQGFEMLINNFTAGIVGAALTILAFYAIGPVV LTLNKLLAAGVEVIVHANLLPVASVFVEPAKVLFLNNAINHGILSPIGIEQASQTGKS ILFLVEANPGPGLGILLAYMFFGKGSSKSTAPGAAIIHFFGGIHEIYFPYILMKPALI LAAIAGGASGLLTFTIFNAGLVAAASPGSIIALMAMTPRGGYFGVLAGVLVAAAVSFI VSAVILKSSKASEEDLAAATEKMQSMKGKKSQAAAALEAEQAKAEEASELSPESVNKI IFACDAGMGSSAMGASILRNKVKKAELDISVTNTAINNLPSDADIVITHKDLTDRAKA KLPNATHISVDNFLNSPKYDELIEKLKK*" /label="mtlA CDS" gene 431291..432727 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /label="mtlA gene" CDS 432752..433183 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IIA component" /protein_id="YP_003097678.1" /db_xref="EnsemblGenomes-Gn:BSU03982" /db_xref="EnsemblGenomes-Tr:CAX52549" /db_xref="GOA:C0H3V2" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR016152" /db_xref="UniProtKB/Swiss-Prot:C0H3V2" /translation="MQVLAKENIKLNQTVSSKEEAIKLAGQTLIDNGYVTEDYISKMF EREETSSTFMGNFIAIPHGTEEAKSEVLHSGISIIQIPEGVEYGEGNTAKVVFGIAGK NNEHLDILSNIAIICSEEENIERLISAKSEEDLIAIFNEVN*" /label="mtlF CDS" gene 432752..433183 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /label="mtlF gene" CDS 433185..434306 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /EC_number="1.1.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 22014119, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 22014119, 23279188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannitol-1-phosphate 5-dehydrogenase" /protein_id="NP_388281.2" /db_xref="EnsemblGenomes-Gn:BSU03990" /db_xref="EnsemblGenomes-Tr:CAB12207" /db_xref="GOA:P42957" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023027" /db_xref="InterPro:IPR023028" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11216" /db_xref="UniProtKB/Swiss-Prot:P42957" /translation="MIALHFGAGNIGRGFIGALLHHSGYDVVFADVNETMVSLLNEKK EYTVELAEEGRSSEIIGPVSAINSGSQTEELYRLMNEAALITTAVGPNVLKLIAPSIA EGLRRRNTANTLNIIACENMIGGSSFLKKEIYSHLTEAEQKSVSETVGFPNSAVDRIV PIQHHEDPLKVSVEPFFEWVIDESGFKGKTPVINGALFVDDLTPYIERKLFTVNTGHA VTAYVGYQRGLKTVKEAIDHPEIRRVVHSALLETGDYLVKSYGFKQTEHEQYIKKIIG RFENPFISDDVTRVARSPLRKLGENDRLVGPAKKIKEPNALAEGIAAALRFDFTGDPE AVELQALIEEKGYSGVLQEVCGIQSHEPLHAIILKKLNQ*" /label="mtlD CDS" gene 433185..434306 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /label="mtlD gene" downshifts 434289 /Source="Nicolas_upshifts" /id="D178" /incds=0 /nref=46 /ntot=156 /MaxReadThrough="5.56503" /MaxDrop="4.72154" /score="32.3837677" /energy="-13.4" /TU="U307" /idTUdmin="U308" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-35 434335..434338 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-35" promotor_-10 434354..434373 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-10" upshifts 434356 /Source="Nicolas_upshifts" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="upshifts" CDS 434397..435461 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /EC_number="1.1.1.93" /EC_number="1.1.1.83" /EC_number="4.1.1.73" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10568751, 12356321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tartrate dehydrogenase" /protein_id="NP_388282.3" /db_xref="EnsemblGenomes-Gn:BSU04000" /db_xref="EnsemblGenomes-Tr:CAB12208" /db_xref="GOA:P42958" /db_xref="InterPro:IPR011829" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG11222" /db_xref="UniProtKB/Swiss-Prot:P42958" /translation="MTMKQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTA FPWSCDYYLEHGKMMPEDGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELE LSINMRPAKQMAGITSPLLHPNDFDFVVIRENSEGEYSEVGGRIHRGDDEIAIQNAVF TRKATERVMRFAFELAKKRRSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQ HIDALAAFFVTRPETFDVIVASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMF EPVHGSAPDIAGQGLANPIGQIWTAKLMLDHFGEEELGAKILDVMEQVTADGIKTRDI GGQSTTAEVTDEICSRLRKL*" /label="ycsA CDS" gene 434397..435461 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /label="ycsA gene" promotor_-35 434631..434639 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 434653..434672 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 434663 /Source="Nicolas_upshifts" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 435455 /Source="Nicolas_upshifts" /id="D179" /incds=0 /nref=7 /ntot=41 /MaxReadThrough="4.24123" /MaxDrop="4.42639" /score="9.70532694" /energy="-11.6" /TU="U307,U308" /idTUdmin="U308" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 435528..435535 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 435548..435567 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 435561 /Source="Nicolas_upshifts" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 435596..436159 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11856304, 14568161" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11856304, 14568161; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388283.1" /db_xref="EnsemblGenomes-Gn:BSU04010" /db_xref="EnsemblGenomes-Tr:CAB12209" /db_xref="GOA:P42959" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11223" /db_xref="UniProtKB/Swiss-Prot:P42959" /translation="MNAKTITLKKKRKIKTIVVLSIIMIAALIFTIRLVFYKPFLIEG SSMAPTLKDSERILVDKAVKWTGGFHRGDIIVIHDKKSGRSFVKRLIGLPGDSIKMKN DQLYINDKKVEEPYLKEYKQEVKESGVTLTGDFEVEVPSGKYFVMGDNRLNSLDSRNG MGMPSEDDIIGTESLVFYPFGEMRQAK*" /label="sipU CDS" gene 435596..436159 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /label="sipU gene" S_feature 436160..436884 /Source="Nicolas_S_feature" /locus_tag="new_454593_455317" /HighExp="G150, Oxctl, Lbexp, G135, Paraq, dia0, LBGexp, Mt0, G180, dia15" /AntisenseName="yczH" /AntisenseCor="0.134432865921808" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S133" CDS complement(436219..436827) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388284.2" /db_xref="EnsemblGenomes-Gn:BSU04020" /db_xref="EnsemblGenomes-Tr:CAB12210" /db_xref="GOA:O31482" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12782" /db_xref="UniProtKB/Swiss-Prot:O31482" /translation="MFPKPLVILAHEIYGVNSHMKKMGRLIKMAGYDVLTPNLLGEDE VYTLKEEKTAYEQFTKHERLKTGETIIQNVIRQNAGRHIFVIGFSVGATIAWKCSSMP EVSGSVCYYGSRIRDSLHHMPACPVLLFFPNYEPSFDVALLIKKLREKQHTHLEIYQF DALHGFANPDSVYFNRALFFKTLSIIKNGAESRLRTVSSSFF*" /label="yczH CDS" gene complement(436219..436827) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /label="yczH gene" misc_feature complement(436845..436864) /Source="Nicolas_upshift_promotors" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 436861..436867 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(436868) /Source="Nicolas_upshifts" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 436880..436899 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 436886 /Source="Nicolas_upshifts" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 436913..437305 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16291680, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacyl-(acyl carrier protein) dehydratase" /protein_id="NP_388285.2" /db_xref="EnsemblGenomes-Gn:BSU04030" /db_xref="EnsemblGenomes-Tr:CAB12211" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11225" /db_xref="UniProtKB/Swiss-Prot:P42961" /translation="MNSLSLPHRYPFLFIDGVTDSEPGKHAAAYKLISENDWFITDTQ TEMPFSLVIEALAQTAAFTGITDENSLGLLSSVKKAEKLGEAVPGDRLDLTFEVTRNR RGFVFGHAKASVGEQPVAEAEIGIYIEK*" /label="ycsD CDS" gene 436913..437305 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /label="ycsD gene" downshifts 437282 /Source="Nicolas_upshifts" /id="D180" /incds=0 /nref=23 /ntot=189 /MaxReadThrough="1.8721" /MaxDrop="3.42324" /score="-5.4921522" /energy="-13.6" /TU="NA" /idTUdmin="U310" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(437338..437502) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097679.1" /db_xref="EnsemblGenomes-Gn:BSU04039" /db_xref="EnsemblGenomes-Tr:CAX52550" /db_xref="UniProtKB/Swiss-Prot:C0H3V3" /translation="MTEKKQQNKPNENPEHNDLTDPIPNEELKENMNDEKHKRQQRDN SQSERDYDTK*" /label="yczO CDS" gene complement(437338..437502) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /label="yczO gene" downshifts complement(437358) /Source="Nicolas_upshifts" /id="D181" /incds=0 /nref=101 /ntot=193 /MaxReadThrough="1.44096" /MaxDrop="6.55741" /score="22.582242" /energy="-10.6" /TU="NA" /idTUdmin="U313" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(437512..437530) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(437534) /Source="Nicolas_upshifts" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(437545..437551) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 437564..437571 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 437585..437604 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 437588 /Source="Nicolas_upshifts" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="upshifts" CDS 437635..438384 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208, 27435445, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase / 5' nucleotidase" /protein_id="NP_388286.2" /db_xref="EnsemblGenomes-Gn:BSU04040" /db_xref="EnsemblGenomes-Tr:CAB12212" /db_xref="GOA:P42962" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11226" /db_xref="UniProtKB/Swiss-Prot:P42962" /translation="MSVQREDVDIKLIAIDMDGTLLNDEQLISDENRKAIREAEDKGV YVVISTGRTLMTCRELAESLKLSSFLITANGSEIWDSNFNLVERKLLHTDHIQMMWDL RNKHNTNFWASTVNKVWRGEFPENITDHEWLKFGFDIEDDDIRNEVLEELRKNKELEI TNSSPTNIEVNALGINKAAALAKVTEKLGFTMENVMAMGDSLNDIAMIKEAGLGVAMG NAQDIVKETADYITDTNIEDGVAKAIRHWVL*" /label="ribZ CDS" gene 437635..438384 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /label="ribZ gene" downshifts 438361 /Source="Nicolas_upshifts" /id="D182" /incds=0 /nref=219 /ntot=253 /MaxReadThrough="3.23506" /MaxDrop="6.84998" /score="19.5535298" /energy="-11.7" /TU="NA" /idTUdmin="U314" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(438437) /Source="Nicolas_upshifts" /id="D183" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="0.52326" /MaxDrop="2.84763" /score="25.9755124" /energy="-11.7" /TU="NA" /idTUdmin="U313" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" promotor_-35 438467..438473 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 438487..438506 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 438493..438589 /Source="Nicolas_S_feature" /locus_tag="new_456926_457022" /HighExp="S1, Cold, S0, GM 5, BMM, MG 25, Lbtran, aero, GM 10, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S134" upshifts 438493 /Source="Nicolas_upshifts" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 438590..439363 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxoprolinase subunit A" /protein_id="NP_388287.3" /db_xref="EnsemblGenomes-Gn:BSU04050" /db_xref="EnsemblGenomes-Tr:CAB12213" /db_xref="GOA:P42963" /db_xref="InterPro:IPR005501" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG11227" /db_xref="UniProtKB/Swiss-Prot:P42963" /translation="MFQIDLNCDLGESFGAYKIGLDQDILEYVTSANIACGFHAGDPS VMRKTVALAAERGVKMGAHPGLPDLLGFGRRNMAISPEEAYDLVVYQIGALSGFLKAE GLHMQHVKPHGALYNMAAVDQKLSDAIAKAVYKVDPGLILFGLAESELVKAGERIGLQ TANEVFADRTYQSDGTLTPRSQPDALIESDDAAVTQVIKMVKEGAVKSQQGHDVSLKA DTVCIHGDGAHALTFAQKIRKQLKAAGIEVTAISEQRST*" /label="pxpA CDS" gene 438590..439363 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /label="pxpA gene" CDS 439378..440592 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9334321, 15849754, 16850406, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-oxoproline transporter" /protein_id="NP_388288.3" /db_xref="EnsemblGenomes-Gn:BSU04060" /db_xref="EnsemblGenomes-Tr:CAB12214" /db_xref="GOA:P42964" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG11228" /db_xref="UniProtKB/Swiss-Prot:P42964" /translation="MEQQKKTAGKKAGSWSLLMGAAFLMATSAIGPGFLTQTATFTNT LAASFGFVILISIILDIFAQTNVWRIIAVSGKRGQEIANMVLPGLGYFIAILVVLGGL AFNIGNIGGAGLGLQVLFGITPETGALISAVIAILIFVIKEAGKAMDRFTQIAGFVMI ILTVYVAATTAPPVGQAVANTFVPEHISIFAIVTLVGGTVGGYITFAGGHRLLDAGIK GKESIPQVTKSSVVGILITSVMRIALFLAVLGVVSKGLHIDESNPAASVFKLAAGNVG YKIFGLIMWSAAITSVIGAAYTSVSFFKTFSPKIEKNSRGIIIGFIVVSTLAFVTIGQ PAKILVLVGSLNGLILPIALGTLLVAAYKKNIVGDYKHPLWLTSTGALVVIVMAVMGI YTLCTQLPQLWS*" /label="pxpG CDS" gene 439378..440592 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /label="pxpG gene" CDS 440616..441389 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8186229, 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative D-5-oxoproline epimerase" /protein_id="NP_388289.3" /db_xref="EnsemblGenomes-Gn:BSU04070" /db_xref="EnsemblGenomes-Tr:CAB12215" /db_xref="GOA:P42966" /db_xref="InterPro:IPR009906" /db_xref="InterPro:IPR016938" /db_xref="SubtiList:BG11230" /db_xref="UniProtKB/Swiss-Prot:P42966" /translation="MAPKDVRALIREGKINGPTAGMSGGYAQANLVVLKKDLAFDFLL FCQRNQKPCPVLDVTEAGSPVPSLAAPDADIRTDFPKYRIYRHGILTEEVSDITPYWE DDFVGFLIGCSFSFEQALINNGIAVRHIDEGTNVSMYKTNIDCVPAGAFHGQMVVSMR PVPERLAVRAAQVTSRFPAVHGGPIHIGNPGAIGIRDLGKPDFGDAVSIRDGEVPVFW ACGVTPQAVAMNVKPEMVITHAPGHMLITDIRDESLAVL*" /label="pxpI CDS" gene 440616..441389 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /label="pxpI gene" CDS 441434..442156 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /EC_number="3.5.2.9" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit B" /protein_id="NP_388290.2" /db_xref="EnsemblGenomes-Gn:BSU04080" /db_xref="EnsemblGenomes-Tr:CAB12216" /db_xref="GOA:P60495" /db_xref="InterPro:IPR003833" /db_xref="InterPro:IPR010016" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR029000" /db_xref="PDB:2KWA" /db_xref="PDB:2ZP2" /db_xref="SubtiList:BG11231" /db_xref="UniProtKB/Swiss-Prot:P60495" /translation="MTVRYQIEQLGDSAMMIRFGEEINEQVNGIVHAAAAYIEEQPFP GFIECIPAFTSLTVFYDMYEVYKHLPQGISSPFESVKRDVEERLAEIAEDYEVNRRIV EIPVCYGGEFGPDLEEVAKINQLSPEEVIDIHTNGEYVVYMLGFAPGFPFLGGMSKRI AAPRKSSPRPSIPAGSVGIAGLQTGVYPISTPGGWQLIGKTPLALFRPQENPPTLLRA GDIVKFVRISEKDYHAYKEESN*" /label="pxpB CDS" gene 441434..442156 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /label="pxpB gene" CDS 442159..443166 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit C" /protein_id="YP_054571.2" /db_xref="EnsemblGenomes-Gn:BSU04090" /db_xref="EnsemblGenomes-Tr:CAE01447" /db_xref="GOA:Q7WY77" /db_xref="InterPro:IPR003778" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG14193" /db_xref="UniProtKB/Swiss-Prot:Q7WY77" /translation="MKVLKPGLLTTVQDIGRTGYQKYGVLASGAMDTVSLRIANLLIG NGENEAGLEITMMGPGPSFHFSKQTLIAVTGADFTLRINDEEAPLWKPVLIKENSTVS FGPCKLGSRAYLAAAGGIEVPAVMESKSTYVRGSIGGLHGRALQKEDELNIGEMSALS QTILSRLSSQLGKQGFAAPKWSVSRGRFLPLKKNPVIRVLEGKQFAFFTEESKTRFYE EAFRVTPQSDRMGYRLKGEPLELKAPLEMVSEAVSFGTVQVPPDGNPIILLADRQTTG GYPRIAHIISADLPIVSQIMPGEHVQFEPVSLQEAEALAVEREQHIKELKTRMKMEWL T*" /label="pxpC CDS" gene 442159..443166 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /label="pxpC gene" downshifts 442652 /Source="Nicolas_upshifts" /id="D184" /incds=1 /nref=6 /ntot=27 /MaxReadThrough="5.04721" /MaxDrop="4.5277" /score="-7.2426149" /energy="-12.4" /TU="U315" /idTUdmin="U315" /TUdmin="-1975" /isTUend="FALSE" /label="downshifts" promotor_no_box 442746..442846 /Source="Nicolas_upshift_promotors" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 442806 /Source="Nicolas_upshifts" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 443182..443934 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9334321; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the pxp operon (IclR family)" /protein_id="NP_388291.2" /db_xref="EnsemblGenomes-Gn:BSU04100" /db_xref="EnsemblGenomes-Tr:CAB12217" /db_xref="GOA:P42968" /db_xref="InterPro:IPR005471" /db_xref="InterPro:IPR014757" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11214" /db_xref="UniProtKB/Swiss-Prot:P42968" /translation="MQNKNKTVVKSMALLNLFLHKPSLTLSELVSLTGMPKTSVHRMV SSLEEMGFLSRDASGAYSLGLVFLEFGQLVADRLDIRKIAKPVMEELCREVDEAVQLI MRDGNEAIYVEKIEGTQTVRLYTAIGRRSPLYAGACARSILSFLPREEIEAYIKQTEL ISIGSGTITDPEKLLQEIDASVQNGYTVSYSELENYTAAIGAPIFNHERQVAAGISIA GFEARFTEDRLPYLTEKVKDAALQISRKIGYT*" /label="pxpR CDS" gene 443182..443934 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /label="pxpR gene" promotor_-35 443932..443941 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 443955..443974 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 443965 /Source="Nicolas_upshifts" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 443998..444639 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /EC_number="3.1.1.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 17220230, 20057119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 17220230, 20057119; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat phospholipase B" /protein_id="NP_388292.1" /db_xref="EnsemblGenomes-Gn:BSU04110" /db_xref="EnsemblGenomes-Tr:CAB12218" /db_xref="GOA:P42969" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11232" /db_xref="UniProtKB/Swiss-Prot:P42969" /translation="MVLRYTALGDSLTTGRGSGLFSPGFVQRFGDMMEADLKTRTAIN IFARSGLNTEEILGLLSYPYVQKCIRDADMITITGCGNDLIDSVLAYQTSKDETIFSR VSAHCHENFEKMIAKVAEIKGENPSPYAIRVFNLYNPFPEIDIAGKWITSFNSHLETL ASAPHVKIADAYSIFKGKEQEYLSFDGVHPNSKGYQAMAEAVHKLGYKELSVS*" /label="lipC CDS" gene 443998..444639 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /label="lipC gene" downshifts 444625 /Source="Nicolas_upshifts" /id="D185" /incds=0 /nref=106 /ntot=223 /MaxReadThrough="0.550230000000001" /MaxDrop="6.63515" /score="26.7371783" /energy="-11.8" /TU="NA" /idTUdmin="U315" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(444637..445062) /Source="Nicolas_S_feature" /locus_tag="new_463070_463495_c" /HighExp="S1, Sw, BC, S2, Lbtran, M0t90, LPhT, BI, M40t45, C90" /AntisenseName="yczI" /AntisenseCor="-0.57558682544748696" /AntisenseRegPval="-24.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S135" downshifts complement(444682) /Source="Nicolas_upshifts" /id="D186" /incds=0 /nref=171 /ntot=252 /MaxReadThrough="1.91715" /MaxDrop="5.13764" /score="6.4765859" /energy="-11.8" /TU="NA" /idTUdmin="U319" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 444715..444721 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 444735..444754 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 444736 /Source="Nicolas_upshifts" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="upshifts" CDS 444812..445057 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388293.1" /db_xref="EnsemblGenomes-Gn:BSU04120" /db_xref="EnsemblGenomes-Tr:CAB12219" /db_xref="GOA:P42970" /db_xref="InterPro:IPR025018" /db_xref="SubtiList:BG12783" /db_xref="UniProtKB/Swiss-Prot:P42970" /translation="MFRIFKMSFAVIIIILALIAFNYTEHTSVIQSVMLVFLGAVMFM QGLEERKKENDGSGAFNIYTAVFVWSVSLIGFTLHII*" /label="yczI CDS" gene 444812..445057 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /label="yczI gene" S_feature 445058..445468 /Source="Nicolas_S_feature" /locus_tag="new_463491_463901" /HighExp="T5.0H, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, M9-stat, T-4.40H, T-3.40H" /AntisenseName="yczJ" /AntisenseCor="-0.20847541933848601" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S136" CDS complement(445063..445350) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388294.1" /db_xref="EnsemblGenomes-Gn:BSU04130" /db_xref="EnsemblGenomes-Tr:CAB12220" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12784" /db_xref="UniProtKB/Swiss-Prot:O31484" /translation="MVREAAMLHIKEGLEQEFEDAFRQAAPIISGMKGYITHSLSKCM EETHKYLLLVEWETLEDHTEGFRGSSEYQEWKALLHRFYTPFPTVEHFQDV*" /label="yczJ CDS" gene complement(445063..445350) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /label="yczJ gene" misc_feature complement(445371..445390) /Source="Nicolas_upshift_promotors" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(445387) /Source="Nicolas_upshifts" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 445444..445448 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 445465..445484 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 445470 /Source="Nicolas_upshifts" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 445501..447507 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8830698, 10648534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830698, 10648534; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="penicillin-binding lipoprotein 3; transpeptidase" /protein_id="NP_388295.1" /db_xref="EnsemblGenomes-Gn:BSU04140" /db_xref="EnsemblGenomes-Tr:CAB12221" /db_xref="GOA:P42971" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR007887" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR032710" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11234" /db_xref="UniProtKB/Swiss-Prot:P42971" /translation="MLKKCILLVFLCVGLIGLIGCSKTDSPEDRMEAFVKQWNDQQFD DMYQSLTKDVKKEISKKDFVNRYKAIYEQAGVKNLKVTAGEVDKDDQDNKTMKHIPYK VSMNTNAGKVSFKNTAVLKLEKTDDEESWNIDWDPSFIFKQLADDKTVQIMSIEPKRG QIYDKNGKGLAVNTDVPEIGIVPGELGDKKEKVIKELAKKLDLTEDDIKKKLDQGWVK DDSFVPLKKVKPDQEKLVSEATSLQGVTRTNVSSRYYPYGEKTAHLTGYVRAITAEEL KKKKEGTYSDTSNIGIAGLENVYEDKLRGTTGWKIYVPQTGEVIAEKKAKDGEDLHLT IDIKTQMKLYDELKDDSGAAVALQPKTGETLALVSAPSYDPNGFIFGWSDKEWKKLNK DKNNPFSAKFNKTYAPGSTIKPIAAAIGIKNGTLKADEKKTIKGKEWQKDSSWGGYSV TRVSERLQQVDLENALITSDNIYFAQNALDMGADTFTKGLKTFGFSEDVPYEFPIQKS SIANDKLDSDILLADTGYGQGQMQMSPLHLATAYTPFVDNGDLVKPTLIKKDSQTADV WHKQVVTKEGAADITKGLKGVVEDERGSAYQPVVKGITVAGKTGTAELKTSKDDKDGT ENGWFVGYDYENKDLLVAMMIQNVQDRGGSHYVVEKAKKQFQSN*" /label="pbpC CDS" gene 445501..447507 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /label="pbpC gene" S_feature 447508..447608 /Source="Nicolas_S_feature" /locus_tag="new_465941_466041" /HighExp="LBGstat, T5.0H, M0t45, T3.30H, S0, LBGtran, Oxctl, T4.0H, C30, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.946, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S137" CDS 447609..448511 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388296.1" /db_xref="EnsemblGenomes-Gn:BSU04150" /db_xref="EnsemblGenomes-Tr:CAB12222" /db_xref="GOA:P42972" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11235" /db_xref="UniProtKB/Swiss-Prot:P42972" /translation="MQRIQLAEDLQFSRVIHGLWRLNEWNYSDAELLSLIEWCIDHGI TTFDHADIYGGYTCEKLFGNALALSPGLRENIELVTKCGIVLESPERPAHRSHHYNTS KSHILASVEQSLMNLRTDYIDMLLIHRPDPLMDPEGVAEAFQALKCSGKVRYFGVSNF KDHQYRMLESYLPEKLVTNQIELSAYELENMLDGTLNLCQEKRIPPMAWSPLAGGKVF TENTDKDRRVRTALESVQGEIGAASLDEVMYAWLYTHPAGIMPIVGSGKRERISAAIN ALSYKLDQDQWFRIFTAVQGYDIP*" /label="ycsN CDS" gene 447609..448511 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /label="ycsN gene" downshifts 448491 /Source="Nicolas_upshifts" /id="D187" /incds=0 /nref=48 /ntot=206 /MaxReadThrough="3.20352" /MaxDrop="4.57855" /score="1.36962171" /energy="-10.6" /TU="U320" /idTUdmin="U318" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 448584..448591 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 448605..448624 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 448609..448696 /Source="Nicolas_S_feature" /locus_tag="new_467042_467129" /HighExp="S0, Gly, BC, Lbstat, S2, M9-stat, G135, dia5, T0.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S138" upshifts 448609 /Source="Nicolas_upshifts" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 448697..450781 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188, 24196428, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188, 24196428, 26159071; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, PTS-dependent activator" /protein_id="NP_388297.1" /db_xref="EnsemblGenomes-Gn:BSU04160" /db_xref="EnsemblGenomes-Tr:CAB12223" /db_xref="GOA:P96574" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG12049" /db_xref="UniProtKB/Swiss-Prot:P96574" /translation="MYMTAREQKLLKHLLLQNRYITVTELAELMQVSTRTIHRELKSI KPLMETVGLTLDKQPGKGLKAVGSPEGKQKLLTDLSYEQHEYSADERKLLILCSLLES QEPVKLYTLAHDLQVTNATVSYDLDELEKWISPFGLTLIRKRGFGIQLIGPENAKRKI VGNLIVNRLDIQMFLEAVELNIKGKTDSSEKMFGVVSKGELLKMERILFQLKEKIAFS LSDSSYIALVVHLTYAIERIKLGETITMEQNELEELMNAKEYSSALEIAGELERAFGV TIPEAEVGYITIHLRSANRKYKTEYKAQEIELETALQTKRLIAFISDKIRMDLTKNYS LYEGLIAHLEPAVSRIKENIEIYNPMKEQIKRDYFLLYMAIEEGVEKYFPGMSFSDDE IAFIVLHFGSALEIKKEEAKVKALVVCSSGIGSSKMLASRLKKELPEIESFDMSSLIE LKGKDVQAYDMIVSTVPIPYENIDYIMVSPLLNEEDANQVKQYIKRKIPLILNKKRSS KEEAQQADVPDMLEAAESIGRYMEVIQDVLRHFTLAQLKTNPDHSMLLLELFQQLKKD GLIRDPEKAAVCLAEREKQGGLGIPGTNMALYHLKNDEIVLPFFKMFDLSTPYEVDGM DGNTLRMTRILVMMAPGSLSAEGSEILSAISSAIIESGESMAGFQEEGGQELYQRLNR IFFTWMKEKNIL*" /label="mtlR CDS" gene 448697..450781 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /label="mtlR gene" downshifts 450768 /Source="Nicolas_upshifts" /id="D188" /incds=0 /nref=107 /ntot=220 /MaxReadThrough="1.91059" /MaxDrop="5.63565" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U321" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 450810..450816 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 450830..450848 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 450842 /Source="Nicolas_upshifts" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="upshifts" S_feature 450853..450934 /Source="Nicolas_S_feature" /locus_tag="new_469286_469367" /HighExp="Etha, S5, S6, ferm, S8, nit, S7, BT, Salt, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S139" promotor_-35 450896..450903 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 450917..450936 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 450936 /Source="Nicolas_upshifts" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="upshifts" CDS 450993..452504 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA ligase" /protein_id="NP_388298.2" /db_xref="EnsemblGenomes-Gn:BSU04170" /db_xref="EnsemblGenomes-Tr:CAB12224" /db_xref="GOA:P96575" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG12050" /db_xref="UniProtKB/Swiss-Prot:P96575" /translation="METLQHLILHDMPNSEEIEAVKSGDHTLTYKGYRKRINQLANAM LQKGIQKGDRVALLCKNGHPASTVMFAALEIGAVVVPVSWQLKPYEMTGILKASEPKA MFYGAEFKEILDEVLPELSSLCVTMETGTAYETSAEFEALFAGPDHLPETEMVSPDDT ALLMFTSGTTGNPKRCMITHGGIYRYVKKSNSSIARMKGLRFLACHPIYHTSALICIM LGTFAETTFVFTKDQDPVHMLKVIEEEKIQTVMALPVFYTYLLEAWEKHQTDLSSLVI LMTGGTKVPSSLISRYLDIGIPLAHGYGSTEAWGISTWTPDMGMDKAASAGKPVAGVK VKVEDPLTGEELPQGEIGEIVVHTPFLFKGYEDNPEATAKVLQNGWFRTGDSGYVDED GFIFITGRYKDVIIYGGDNVYPDQVEEVIQQIPGILETAVVGIPDPLYGEKPKAFIVK NGGQRITEEDVIAFCKERLSAYKIPEVEFVNELPKNNLGKVKKDVLRNQAVHS*" /label="ydaB CDS" gene 450993..452504 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /label="ydaB gene" downshifts 452488 /Source="Nicolas_upshifts" /id="D189" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.57376" /MaxDrop="3.70168" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U323" /TUdmin=73 /isTUend="FALSE" /label="downshifts" CDS complement(452524..453069) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388299.1" /db_xref="EnsemblGenomes-Gn:BSU04180" /db_xref="EnsemblGenomes-Tr:CAB12225" /db_xref="GOA:P96576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12051" /db_xref="UniProtKB/Swiss-Prot:P96576" /translation="MIAGYIMAAENQTLNQWTINQLGITRGDSILEVGFGPGYCMQQM LKREKDVHLHGIDVSEAMLKLAARRVKPKGVRLIQGSIETFPLPASFYDKVISVNNYT IWNDQTKGIKQIYRALKPGGKAAITMQPREADASPEKTKSFGRQMIADFKAAGFEDID IQFKNIKPELSVCATAKKPAT*" /label="ydaC CDS" gene complement(452524..453069) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /label="ydaC gene" downshifts complement(452557) /Source="Nicolas_upshifts" /id="D190" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="1.44039" /MaxDrop="3.73662" /score="-9.35066962" /energy="-11.5" /TU="NA" /idTUdmin="U324" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(453136..453154) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(453150) /Source="Nicolas_upshifts" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(453169..453175) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 453211..453217 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-35" upshifts 453229 /Source="Nicolas_upshifts" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="upshifts" promotor_-10 453232..453250 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-10" CDS 453276..454136 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528, 21520290, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_388300.1" /db_xref="EnsemblGenomes-Gn:BSU04190" /db_xref="EnsemblGenomes-Tr:CAB12226" /db_xref="GOA:P80873" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12052" /db_xref="UniProtKB/Swiss-Prot:P80873" /translation="MANYPKELPAQTQSRQPGIESEMNPSPVYEYEDYKGADKLKGKV ALITGGDSGIGRAVSVAYAKEGADIAIVYKDEHEDAEETKKRVEQEGVKCLLIAGDVG EEEFCNEAVEKTVKELGGLDILVNNAGEQHPKESIKDITSEQLHRTFKTNFYSQFYLT KKAIDYLKPGSAIINTTSINPYVGNPTLIDYTATKGAINAFTRTMAQALVKDGIRVNA VAPGPIWTPLIPATFPEETVAQFGQDTPMGRPGQPVEHVGCYVLLASDESSYMTGQTL HVNGGNFVTT*" /label="ydaD CDS" gene 453276..454136 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /label="ydaD gene" CDS 454152..454655 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /EC_number="5.3.1.15" /experiment="publication(s) with functional evidences, PMID:10220166, 15805528, 21421786, 21520290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15805528, 21421786, 21520290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lyxose ketol isomerase" /protein_id="NP_388301.1" /db_xref="EnsemblGenomes-Gn:BSU04200" /db_xref="EnsemblGenomes-Tr:CAB12227" /db_xref="GOA:P96578" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:2Y0O" /db_xref="SubtiList:BG12053" /db_xref="UniProtKB/Swiss-Prot:P96578" /translation="MGITKEEVNSYYQKAGIVLTDEEVDQIQLMDYGLGKERKVGLQL FVYVNTDRYCSKELVLFPGQTCPEHRHPPVDGQEGKQETFRCRYGKVYLYVEGEKTPL PKVLPPQEDREHYTVWHEIELEPGGQYTIPPNTKHWFQAGEEGAVVTEMSSTSTDKHD IFTDPRI*" /label="lyxE CDS" gene 454152..454655 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /label="lyxE gene" downshifts 454636 /Source="Nicolas_upshifts" /id="D191" /incds=0 /nref=16 /ntot=26 /MaxReadThrough="4.81615" /MaxDrop="6.21035" /score="29.8440619" /energy="-15.5" /TU="U325" /idTUdmin="U325" /TUdmin="-683" /isTUend="FALSE" /label="downshifts" promotor_-35 454684..454691 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 454705..454724 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 454707 /Source="Nicolas_upshifts" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 454741..455292 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /EC_number="2.3.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15468321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal protein N-acetyltransferase" /protein_id="NP_388302.1" /db_xref="EnsemblGenomes-Gn:BSU04210" /db_xref="EnsemblGenomes-Tr:CAB12228" /db_xref="GOA:P96579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1NSL" /db_xref="SubtiList:BG12054" /db_xref="UniProtKB/Swiss-Prot:P96579" /translation="MFTCKVNEHITIRLLEPKDAERLAELIIQNQQRLGKWLFFAENP SSADTYRETIIPDWRRQYADLNGIEAGLLYDGSLCGMISLHNLDQVNRKAEIGYWIAK EFEGKGIITAACRKLITYAFEELELNRVAICAAVGNEKSRAVPERIGFLEEGKARDGL YVNGMHHDLVYYSLLKREWEGEK*" /label="ydaF CDS" gene 454741..455292 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /label="ydaF gene" promotor_-35 455307..455313 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 455328..455346 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 455341 /Source="Nicolas_upshifts" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 455370..455792 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_388303.1" /db_xref="EnsemblGenomes-Gn:BSU04220" /db_xref="EnsemblGenomes-Tr:CAB12229" /db_xref="GOA:P80238" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG19017" /db_xref="UniProtKB/Swiss-Prot:P80238" /translation="MNQQDIKQKVLDVLDHHKVGSLATVQKGKPHSRYMTFFHDGLTI YTPTSKETHKAEEIENNPNVHILLGYDCEGFGDAYVEVAGKAKINNSAELKDKIWSSK LERWFDGKDDPNLVILEIEPEDIRLMNAGEKTPVSLEL*" /label="ydaG CDS" gene 455370..455792 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /label="ydaG gene" promotor_-35 455797..455805 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 455816..455835 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 455835..456201 /Source="Nicolas_S_feature" /locus_tag="new_474268_474634" /HighExp="Etha, Salt, Cold, Sw, B60, Gly, M9-stat, LPhT, B36, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.999, 1" /TUlongSig="SigB" /TUlongPSig=1 /label="S140" upshifts 455835 /Source="Nicolas_upshifts" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(455861..455961) /Source="Nicolas_upshift_promotors" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" misc_RNA complement(455896..456164) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /product="small regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 23457461" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23457461; Product type n: RNA" /label="bsrC RNA" gene complement(455896..456164) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /label="bsrC gene" upshifts complement(455901) /Source="Nicolas_upshifts" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 456158 /Source="Nicolas_upshifts" /id="D192" /incds=0 /nref=124 /ntot=275 /MaxReadThrough="2.67264" /MaxDrop="7.35087" /score="29.9942993" /energy="-12" /TU="NA" /idTUdmin="U326" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 456238..456247 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 456260..456275 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 456265 /Source="Nicolas_upshifts" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 456298..457107 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_388304.1" /db_xref="EnsemblGenomes-Gn:BSU04230" /db_xref="EnsemblGenomes-Tr:CAB12230" /db_xref="GOA:P96581" /db_xref="InterPro:IPR021260" /db_xref="SubtiList:BG12055" /db_xref="UniProtKB/Swiss-Prot:P96581" /translation="MHVITTQVLFIFCFLLLIHSIETLAYATRLSGARVGFIASALSL FNVMVIVSRMSNMVQQPFTGHLIDDAGKNALAIVGEQFRFLIFGSTVGTILGIILLPS FVALFSRAIIHLAGGGGSVFQVFRKGFSKQGFKNALSYLRLPSISYVKGFHMRLIPKR LFVINMLITSIYTIGVLSALYAGLLAPERSTTAVMASGLINGIATMLLAIFVDPKVSV LADDVAKGKRSYIYLKWTSVTMVTSRVAGTLLAQLMFIPGAYYIAWLTKWF*" /label="amj CDS" gene 456298..457107 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /label="amj gene" downshifts 457088 /Source="Nicolas_upshifts" /id="D193" /incds=0 /nref=5 /ntot=103 /MaxReadThrough="2.92236" /MaxDrop="3.54247" /score="15.7032536" /energy="-14.9" /TU="U330" /idTUdmin="U327" /TUdmin=911 /isTUend="FALSE" /label="downshifts" CDS complement(457151..457441) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388305.1" /db_xref="EnsemblGenomes-Gn:BSU04240" /db_xref="EnsemblGenomes-Tr:CAB12231" /db_xref="GOA:O31485" /db_xref="InterPro:IPR023845" /db_xref="SubtiList:BG12807" /db_xref="UniProtKB/Swiss-Prot:O31485" /translation="MLHTPIGRLRTMGFIEGMSLLILLFIAMPLKYWAGLPLAVTIVG SVHGGLFILYLLVLAYATFSVKWPLKWSAAGFIAAFVPFGNFLYDRGLRNYK*" /label="ydzA CDS" gene complement(457151..457441) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /label="ydzA gene" downshifts complement(457155) /Source="Nicolas_upshifts" /id="D194" /incds=0 /nref=235 /ntot=260 /MaxReadThrough="1.23465" /MaxDrop="7.74945" /score="10.1798531" /energy="-14.9" /TU="NA" /idTUdmin="U332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(457469..457488) /Source="Nicolas_upshift_promotors" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 457469..457487 /Source="Nicolas_upshift_promotors" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 457475 /Source="Nicolas_upshifts" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(457485) /Source="Nicolas_upshifts" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 457563..457570 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 457584..457603 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 457588 /Source="Nicolas_upshifts" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 457626..458060 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9341680, 10606655, 10913073, 12458218, 16407330, 16528101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341680, 10606655, 10913073, 12458218, 16407330, 16528101; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388306.1" /db_xref="EnsemblGenomes-Gn:BSU04250" /db_xref="EnsemblGenomes-Tr:CAB12232" /db_xref="GOA:P96582" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2CFX" /db_xref="SubtiList:BG12056" /db_xref="UniProtKB/Swiss-Prot:P96582" /translation="MKLDQIDLNIIEELKKDSRLSMRELGRKIKLSPPSVTERVRQLE SFGIIKQYTLEVDQKKLGLPVSCIVEATVKNADYERFKSYIQTLPNIEFCYRIAGAAC YMLKINAESLEAVEDFINKTSPYAQTVTHVIFSEIDTKNGRG*" /label="lrpC CDS" gene 457626..458060 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /label="lrpC gene" promotor_-35 458057..458060 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 458069 /Source="Nicolas_upshifts" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 458077..458096 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 458125..460308 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /EC_number="5.99.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16192570, 16556226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase III" /protein_id="NP_388307.1" /db_xref="EnsemblGenomes-Gn:BSU04260" /db_xref="EnsemblGenomes-Tr:CAB12233" /db_xref="GOA:P96583" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005738" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR034144" /db_xref="SubtiList:BG11979" /db_xref="UniProtKB/Swiss-Prot:P96583" /translation="MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGH LVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVI ATDAGREGELVARWIIEKANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSA VARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIR AAVDGMTLTWQDKKSKQTRTFNQDVTSRLLKNLQGKQAVVAELKKTAKKSFAPALYDL TELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGME VKPYAQYVSQIKKRGIKSHKGYVNDAKVSDHHAIIPTEEPLVLSSLSDKERKLYDLIA KRFLAVLMPAFEYEETKVIAEIGGETFTAKGKTVQSQGWKAVYDMAEEDDEQEDDRDQ TLPALQKGDTLAVRTLTETSGQTKPPARFNEGTLLSAMENPSAFMQGEEKGLVKTLGE TGGLGTVATRADIIEKLFNSFLIEKKGQDIFITSKGKQLLQLVPEDLKSPALTAEWEQ KLSAIAAGKLKSAVFIKDMKAYAHQTVKEIKNSSQTFRHDNITGTACPECGKMMLKVN GKRGTMLVCQDRECGSRKTIARKTNARCPNCHKRMELRGQGEGQTFACVCGHREKLSV FEKRKNKDKARATKRDVSSYMKKQNKDEPINNALAEQLKKLGLDK*" /label="topB CDS" gene 458125..460308 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /label="topB gene" downshifts 460291 /Source="Nicolas_upshifts" /id="D195" /incds=0 /nref=133 /ntot=245 /MaxReadThrough="3.22367" /MaxDrop="6.18597" /score="23.5229393" /energy="-10.4" /TU="U334" /idTUdmin="U333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 460357..460363 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 460378..460396 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 460379..460510 /Source="Nicolas_S_feature" /locus_tag="new_478812_478943" /HighExp="Etha, Salt, Heat, Cold, H2O2, G180, LPhT, Oxctl, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S141" upshifts 460379 /Source="Nicolas_upshifts" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="upshifts" CDS 460511..461599 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 26078454, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 26078454, 27897378; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="glycosyl hydrolase lipoprotein" /protein_id="NP_388308.1" /db_xref="EnsemblGenomes-Gn:BSU04270" /db_xref="EnsemblGenomes-Tr:CAB12234" /db_xref="GOA:O31486" /db_xref="InterPro:IPR008928" /db_xref="SubtiList:BG12057" /db_xref="UniProtKB/Swiss-Prot:O31486" /translation="MRHVLIAVILFFLSIGLSAGCAEAGNKTQNQSATEVNASPLQPA EYFIYHNLMNDKGLIKTDFSDQPSYLSESLGLWMEFLLSKNDAPHFQDQYQHLTDSFL MSNHLVTWKIQNGQASGTNALIDDMRIMLSLDQAAAKWGRSDYAQTARDIGTSLKTYN MNNGFFTDFYDSQAASKDVTLSYVMPDALAVLKKNGIIDEETEQRNANVLYSAPLKNG FLPKTYSSETKEYTYDSEINLIDQLYAAWHLPEGDEKASVLADWIKQEFQKNGKLYGR YSAYTKEPAVQYESPSVYALAVLFLTKQHENSSVIKAIYDRMNDFEIHDPVKSYYGGY MSGTQTHSFDNLLPLLAERKLFNENIIQ*" /label="epsJ CDS" gene 460511..461599 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /label="epsJ gene" CDS 461580..462431 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23893111, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111, 27897378; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic-di-GMP receptor" /protein_id="NP_388309.1" /db_xref="EnsemblGenomes-Gn:BSU04280" /db_xref="EnsemblGenomes-Tr:CAB12235" /db_xref="GOA:P96585" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG12058" /db_xref="UniProtKB/Swiss-Prot:P96585" /translation="MKISFSESQKLFAYFSGLIAALSLFIYYVSAQQSEGALILCITF GVIAAGIWFGPIYALAVTLIVLFVLGTLMMFFQTGQTSLFPAEEGLRMLVVWGIALLL FSFISGRIHDITAELRRSMTRLQSEIKSYVAVDRVTGFDNKQRMKLELSEEIKRAERY GNSFVFLLLHMHYFKEFKSLYGEKETDRLFQYVGQQIRTSVRETDKKFRPSDERIGIV LTHTPAEHMPAVLTKLKKQLDTYQLENGKYVSLTFHVCYLPYRNDIQTADQFLEELEN EMMMNEL*" /label="epsK CDS" gene 461580..462431 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /label="epsK gene" CDS 462442..464151 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27897378; Product type ph :phenotype" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388310.1" /db_xref="EnsemblGenomes-Gn:BSU04290" /db_xref="EnsemblGenomes-Tr:CAB12236" /db_xref="GOA:O31487" /db_xref="InterPro:IPR018763" /db_xref="SubtiList:BG12059" /db_xref="UniProtKB/Swiss-Prot:O31487" /translation="MLCVMMLLFSAIASFPVSAQAKDQDAGILIIYSTLDGKESSQVK MLDLLAGHFTSHVTVKKDSDVEASDFKGKDHVIYYGQTKRKLSQKLLSLISGVKKPVV AIGYNAGQISQFSGLSLARKENVFQVHSRSEKADVSLESGLNVLSVSGLKGTALYTFK ADEGTTHSFIWKTKKGNVYIGLTNLLNDNLIVAKQLREAFGEKAGTTLLYLRLEDISP MSDEKLLLQAGTYLHKRHIPFILAVIPVYLNPETGDKVYLSNQPKMVKVLKKLQSMGG SIIVHGYTHAYRYSETGEGFEFWDAKADQPITSGNAEDPPSILEKEQDFPNEQAYHSY LEPFREKEETYTKQKLTRAIEDLTSSGLYPLAFEAPHYTMSEYGYQIASQYFTSIFGQ VQLSSTTWKTSGAPPFVTAPSMLHGMTLYPETIGFVDTSKQNPLGEMEEHISQMIDFE GGVAGGFYHPYLGMKYLPELVDQMERIPDSEWLDLKKTKQTVKTDKVEIHTSGDGTIQ VKNGVSPIYEFFDHHRQTPLEKALWILSAVVLLFVIMFVSYTFYLRATLKKRIFKERR SLG*" /label="ydaL CDS" gene 462442..464151 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /label="ydaL gene" CDS 464144..465406 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /EC_number="2.4.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378, 28296273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase associated to biofilm formation" /protein_id="NP_388311.1" /db_xref="EnsemblGenomes-Gn:BSU04300" /db_xref="EnsemblGenomes-Tr:CAB12237" /db_xref="GOA:P96587" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12060" /db_xref="UniProtKB/Swiss-Prot:P96587" /translation="MGNTLFFISLSLIWVMLLYHMFLMQGGFRHYMTFERNIPKWREN MKELPKVSVLIPAHNEEVVIRQTLKAMVNLYYPKDRLEIIVVNDNSSDRTGDIVNEFS EKYDFIKMVITKPPNAGKGKSSALNSGFAESNGDVICVYDADNTPEKMAVYYLVLGLM NDEKAGAVVGKFRVINAAKTLLTRFINIETICFQWMAQGGRWKWFKIATIPGTNFAIR RSIIEKLGGWDDKALAEDTELTIRVYNLGYHIRFFPAAITWEQEPETWKVWWRQRTRW ARGNQYVVLKFLAQFFKLKRKRIIFDLFYFFFTYFLFFFGVIMSNAIFVVNLFYDLHL SVGFLAMILWILAFFLFMTEVMITLSIEKTEMNKQNFFIVFLMYFTYSQAWIVLVIYS LFVEIKHRLFKQEVKWYKTERYNQHKSG*" /label="ydaM CDS" gene 464144..465406 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /label="ydaM gene" CDS 465412..467523 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative regulator of exopolysaccharide synthesis" /protein_id="NP_388312.1" /db_xref="EnsemblGenomes-Gn:BSU04310" /db_xref="EnsemblGenomes-Tr:CAB12238" /db_xref="GOA:O31488" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR018513" /db_xref="SubtiList:BG12061" /db_xref="UniProtKB/Swiss-Prot:O31488" /translation="MKQIMIFLTSFMLLAMTGQTALAKDVQVSGSLLGKSSQEQAKQQ VLTSELITLYGSKDSAELTYQIPAGASSGNQQLVIEYEASNLLISPSSLTVVIDDEPV KTLKLDGDSKRKTVKLNLNKSQSAQGYHNVSLKFYGVMKEGVCVRQDTSGNWIKIYPD SRLTLADSSEAKGTSLDHYPYPFAQSGNTAEETAIVIPDNPSSAEIEAAVKTEGYLKT VDSSVSIAYVTESELKKIDKPTIVIGVDKHWNGKVKKLLKQAGLQAKGENLLLAERVL KAEGKQQPVLFAQAASEDALTKKISVMTDQTYTGQLSGDTLSISKLQQTEKKESDKLT LENFGAGDITIGADKTSSAHYFYPASAVLDENQSAKLSLKLKKSETIQASTAENESAS QAAELKVMINGQPHSVRLDELGKEDKNGFYHVTVKVDPKLLQKNRYIDIQFVTTGLKE NNPCNTTDEEKWVFIDKNSTLSYAIKGMSPSADFQEWPLPYAGNQDQTTLIVLPDTVS QSKLEELSLVTESFGNEAQHSYTVKKSSDVTANDAKGRNLIFIGGINQFSLLKEKSSD LLVPQEKNGSFDVSSFEMLNETTKQVVFTQASVWDSRYTMAVFAPSKGDGTAVTKEII SYLNSNDESATVLNETNSQQVFTNHQQLKSETNSSDAEQPTQDHSQKWMYIGVLALIM VVAAVFIWIAVRRKKRKTDTE*" /label="ydaN CDS" gene 465412..467523 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /label="ydaN gene" downshifts 467507 /Source="Nicolas_upshifts" /id="D196" /incds=0 /nref=18 /ntot=91 /MaxReadThrough="0.438479999999999" /MaxDrop="4.36576" /score="34.1370207" /energy="-9.9" /TU="NA" /idTUdmin="U336" /TUdmin="-4598" /isTUend="FALSE" /label="downshifts" promotor_-35 467620..467627 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 467642..467661 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 467649 /Source="Nicolas_upshifts" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 467659..467802 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /product="ATP-, cyclic di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 20511502, 23086297, 25086507, 25086509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 20511502, 23086297, 25086507, 25086509; Product type n: RNA" /function="16.3: Control" /label="swaO RNA" gene 467659..467802 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /label="swaO gene" downshifts 467800 /Source="Nicolas_upshifts" /id="D197" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="7.43698" /MaxDrop="5.83561" /score="30.4392599" /energy="-14.7" /TU="U336" /idTUdmin="U336" /TUdmin="-4305" /isTUend="FALSE" /label="downshifts" S_feature 467845..467998 /Source="Nicolas_S_feature" /locus_tag="new_486278_486431" /HighExp="LPhT, LBGstat, LPh, T-1.10H, T-0.40H, G135, G180, T-1.40H, G150, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S142" CDS 467999..469822 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cyclic di-AMP controlled transporter of potassium" /protein_id="NP_388313.1" /db_xref="EnsemblGenomes-Gn:BSU04320" /db_xref="EnsemblGenomes-Tr:CAB12239" /db_xref="GOA:P96589" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12062" /db_xref="UniProtKB/Swiss-Prot:P96589" /translation="MYHSIKRFLIGKPLKSQAAGEQKLTKLKALAMLSSDALSSVAYG TEQILIILATISAAAFWYSIPIAVGVLILLLALILSYRQIIYAYPQGGGAYIVSKENL GEKPGLIAGGSLLVDYILTVAVSISAGTDAITSAFPALHDYHVPIAIFLVLVIMILNL RGLSESASILAYPVYLFVVALLVLIAVGLFKLMTGQIDQPAHHTSLGTPVAGITLFLL LKAFSSGCSALTGVEAISNAIPAFKNPPARNAARTLAMMGILLAILFSGITVLAYGYG TAPKPDETVVSQIASETFGRNVFYYVIQGVTSLILVLAANTGFSAFPQLAFNLARDQY MPRMFTVRGDRLGFSNGIIFLGFASIVLIILFGGQTEHLIPLYAVGVFIPFTLSQTGM CMKWIKQKPKGWIGKMLINSCGALISFMVLSILFVTKFNVVWPVLIFMPIVVLLFFAI KNHYTAVGEQLRIVDKEPEEIKGTVVIVPVAGVTTVVQKSIHYAKSLSDQVIAVHVSF DREQEKKFEKRWEELNNGVRLVTLHSSYRSLVHPFDKFLETVEAKAKKEQFSVMVLFP QFITKKRWHTILHNQSAFLLRVRLFWKKDIMVATLPYHFKK*" /label="kimA CDS" gene 467999..469822 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /label="kimA gene" downshifts 469814 /Source="Nicolas_upshifts" /id="D198" /incds=0 /nref=50 /ntot=181 /MaxReadThrough="3.55206" /MaxDrop="4.7232" /score="6.00201196" /energy="-13.9" /TU="U336" /idTUdmin="U336" /TUdmin="-2291" /isTUend="FALSE" /label="downshifts" CDS 469881..470330 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /EC_number="3.6.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576788, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NTP pyrophosphohydrolase" /protein_id="NP_388314.1" /db_xref="EnsemblGenomes-Gn:BSU04330" /db_xref="EnsemblGenomes-Tr:CAB12240" /db_xref="GOA:P96590" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11956" /db_xref="UniProtKB/Swiss-Prot:P96590" /translation="MYTQGAFVIVLNESQQILLVKRKDVPLWDLPGGRVDPGESAEEA AVREILEETGYNAALSAKIGVYQRPKFQDEQHLFFGSITGGQAMADGTETAGLKWVSP GRLPLFMVPNRKRQINDFKNGAQDVNVTVKDSGLLAAIDLLKRRLGK*" /label="nudT CDS" gene 469881..470330 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /label="nudT gene" promotor_-35 470343..470349 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 470364..470382 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 470365 /Source="Nicolas_upshifts" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="upshifts" CDS 470397..472121 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /EC_number="1.2.3.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291680, 16513748, 10220166, 23611909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-phosphate generating pyruvate oxidase" /protein_id="NP_388315.1" /db_xref="EnsemblGenomes-Gn:BSU04340" /db_xref="EnsemblGenomes-Tr:CAB12241" /db_xref="GOA:P96591" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12063" /db_xref="UniProtKB/Swiss-Prot:P96591" /translation="MAHKTAGQAMTELLEQWGVDHVYGIPGDSINEFIEELRHERNQL KFIQTRHEEVAALAAAAEAKLTGKIGVCLSIAGPGAVHLLNGLYDAKADGAPVLAIAG QVSSGEVGRDYFQEIKLEQMFEDVAVFNREVHSAESLPDLLNQAIRTAYSKKGVAVLS VSDDLFAEKIKREPVYTSPVYIEGNLEPKKEQLVTCAQYINNAKKPIILAGQGMKKAK RELLEFADKAAAPIVVTLPAKGVVPDKHPHFLGNLGQIGTKPAYEAMEECDLLIMLGT SFPYRDYLPDDTPAIQLDSDPAKIGKRYPVTAGLVCDSALGLRELTEYIERKEDRRFL NACTEHMQHWWNEIEKDETEATTPLKPQQVVARLQEAAADDAVLSVDVGTVTVWMARH FKMNANQDFIVSSWLATMGCGLPGAIAASLSEPERQAIAVCGDGGFSMVMQDLPTAVK YKLPITVVILNNENLGMIEYEQQVKGNIDYVTKLQNVDYAAFAESCGAKGIKVTKAEE LAPAFHEALHSDQPVVVDVMIGNEPPLPGKITYGQAKGFSKYMLKNFFENQKFEMPSL KKSLKRLF*" /label="poxB CDS" gene 470397..472121 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /label="poxB gene" S_feature complement(471233..472092) /Source="Nicolas_S_feature" /locus_tag="new_489666_490525_c" /HighExp="H2O2, Paraq, G180, G150, Oxctl, Diami, dia15, G135, C30, dia5" /AntisenseName="ydaP" /AntisenseCor="-5.0529608261635599E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S143" S_feature complement(472094..472205) /Source="Nicolas_S_feature" /locus_tag="new_490527_490638_c" /HighExp="dia5, M0t45, S0, S2, S1, Paraq, GM 120, Lbstat, MG 5, UNK1" /AntisenseName="ydaP" /AntisenseCor="1.7026698118644101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S144" downshifts 472105 /Source="Nicolas_upshifts" /id="D199" /incds=0 /nref=50 /ntot=166 /MaxReadThrough="5.18566" /MaxDrop="6.66568" /score="7.55338633" /energy="-5.3" /TU="U337" /idTUdmin="U336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(472113..472316) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513943.1" /translation="MIRISMQGQMHLPLKQDAFVLLSVSSMAKSVPNTYTDHFMNSNM LKIHLFPKKKKKTRALRAPVFLK*" /label="hypothetical protein CDS" gene complement(472113..472316) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /label="gene" downshifts complement(472137) /Source="Nicolas_upshifts" /id="D200" /incds=0 /nref=5 /ntot=55 /MaxReadThrough="4.75809" /MaxDrop="8.06239" /score="11.2659249" /energy="-9.1" /TU="U338,U340,U341" /idTUdmin="U338" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(472165..472265) /Source="Nicolas_upshift_promotors" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 472174..472179 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 472196..472214 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(472205) /Source="Nicolas_upshifts" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature 472206..472421 /Source="Nicolas_S_feature" /locus_tag="new_490639_490854" /HighExp="Etha, S4, S8, S5, C30, S7, B60, S6, Salt, B36" /AntisenseName="ydzK" /AntisenseCor="3.8830946787094797E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigB" /TUshortPSig="0.914, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S145" upshifts 472206 /Source="Nicolas_upshifts" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(472272..472343) /Source="Nicolas_S_feature" /locus_tag="new_490705_490776_c" /HighExp="Sw, B60, dia15, dia5, BI, Etha, BC, M9-stat, C90, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S146" downshifts complement(472315) /Source="Nicolas_upshifts" /id="D201" /incds=0 /nref=21 /ntot=191 /MaxReadThrough="5.39949" /MaxDrop="5.81865" /score="3.34912028" /energy="-20.3" /TU="U340,U341" /idTUdmin="U343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(472344..472610) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_003097680.1" /db_xref="EnsemblGenomes-Gn:BSU04359" /db_xref="EnsemblGenomes-Tr:CAX52551" /db_xref="GOA:C0H3V4" /db_xref="UniProtKB/Swiss-Prot:C0H3V4" /translation="MSVFILFYLWIVPIVIGILCSVAAHKSKGKMRVAPGIAMIVLSI ISLITAFTAGHTNFHVFIGGMFLFGTFLVGSAFPFFFGLKKKEK*" /label="ydzK CDS" gene complement(472344..472610) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /label="ydzK gene" promotor_-10 complement(472626..472645) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(472644) /Source="Nicolas_upshifts" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(472657..472664) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(472714..473991) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton-coupled manganese transporter" /protein_id="NP_388317.1" /db_xref="EnsemblGenomes-Gn:BSU04360" /db_xref="EnsemblGenomes-Tr:CAB12243" /db_xref="GOA:P96593" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG12065" /db_xref="UniProtKB/Swiss-Prot:P96593" /translation="MMNKDITAQSPRSKAVQDALDGKIRGFRGLLPFLGPAFIAAIAY IDPGNFATNISAGSKYGYMLLWVILFSNIMALLIQSLSAKLGIATGKNLPEVAREEFP KPVSIGLWIQGELVIIATDLAEFIGAALGLYLLFGIPMLEASIIAAIGSFAILELQRR GYRSLEAGIAGMLFVVVIAFALQTFFAKPDAVSVMKGLFVPAFHGTDSVLLAAGILGA TVMPHAIYLHSALTQRRVVGKTDAERKKIFRFEFIDILIAMLIAGAINASMLIVAAAL FFKNGLFVEDLDVAFQQFGHLVSPMSAALFGIGLLVAGLSSSSVGTLSGDVIMQGFIN YRIPLYVRRFITIIPPILIIASGVNPTTALVLSQVVLSFGIAFALIPLIMFTSNKRIM GSLINAKWITVVSWLIAVLIVALNVFLIVDTFR*" /label="mntH CDS" gene complement(472714..473991) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /label="mntH gene" downshifts complement(472733) /Source="Nicolas_upshifts" /id="D202" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="5.8826" /MaxDrop="4.8109" /score="28.3182556" /energy="-9.6" /TU="U341,U343" /idTUdmin="U342" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(474053..474072) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(474065) /Source="Nicolas_upshifts" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(474067..474144) /Source="Nicolas_S_feature" /locus_tag="new_492500_492577_c" /HighExp="S6, S8, S7, Etha, S5, Salt, BT, Heat, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S147" promotor_-35 complement(474085..474092) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(474128..474147) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(474144) /Source="Nicolas_upshifts" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(474161..474170) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(474221..474478) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388318.1" /db_xref="EnsemblGenomes-Gn:BSU04370" /db_xref="EnsemblGenomes-Tr:CAB12244" /db_xref="GOA:P96594" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG12066" /db_xref="UniProtKB/Swiss-Prot:P96594" /translation="MLSFLVSLVVAIVIGLIGSAIVGNRLPGGIFGSMIAGLIGAWIG HGLLGTWGPSLAGFAIFPAIIGAAIFVFLLGLIFRGLRKEA*" /label="ydaS CDS" gene complement(474221..474478) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /label="ydaS gene" downshifts complement(474229) /Source="Nicolas_upshifts" /id="D203" /incds=0 /nref=7 /ntot=33 /MaxReadThrough="4.70076" /MaxDrop="4.7213" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" downshifts complement(474295) /Source="Nicolas_upshifts" /id="D204" /incds=1 /nref=2 /ntot=69 /MaxReadThrough="7.55545" /MaxDrop="2.8244" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS complement(474556..475008) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388319.1" /db_xref="EnsemblGenomes-Gn:BSU04380" /db_xref="EnsemblGenomes-Tr:CAB12245" /db_xref="InterPro:IPR018691" /db_xref="SubtiList:BG12067" /db_xref="UniProtKB/Swiss-Prot:P96595" /translation="MPWSMKDYPASLKNLEKPVRKKAIDIANAMIDEGYEEGRAIPIA TSKAKEWAENASTDEIDDFLTHDDETERDADPSSGSGPELMNKAEHVIKHKKGWAVKA EGAKRVSEIKDTKKEAIERAKEIAAHKGTEVIVHLADGSVQRKIKTGS*" /label="ydaT CDS" gene complement(474556..475008) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /label="ydaT gene" promotor_-10 complement(475027..475045) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(475044) /Source="Nicolas_upshifts" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(475059..475065) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 475077 /Source="Nicolas_upshifts" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 475085..475104 /Source="Nicolas_upshift_promotors" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 475126..475944 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388320.1" /db_xref="EnsemblGenomes-Gn:BSU04390" /db_xref="EnsemblGenomes-Tr:CAB12246" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG12068" /db_xref="UniProtKB/Swiss-Prot:P96596" /translation="MPTERKEDLHQQLKEIEKWEKDQQKVWFWEKLSRLPFQLLDKLT PEFIQKKIGKLLDEVGSFVQTGGQYLTSEKQIIRMFQKKLPEEIFESLEDIRKAPLPV MDEIAEGMGKNRTNAATVQGATTGVGGVFTLAADIPAVLGLSLKTLQDIAVAYGYDPK EKKERVFIVKCLQLTSADVVGKRSILQELKHYDQDRTYKNVASQIQGWREVVLGYRDT FGWKKLFQIVPVAGMVFGAAANRSTLNDITETGMMLYKKRRILERLKETEREME*" /label="ydbA CDS" gene 475126..475944 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /label="ydbA gene" downshifts 475935 /Source="Nicolas_upshifts" /id="D205" /incds=0 /nref=118 /ntot=223 /MaxReadThrough="0.66117" /MaxDrop="4.41502" /score="5.38936313" /energy="-9.2" /TU="NA" /idTUdmin="U344" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 476012..476018 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476032..476050 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476040 /Source="Nicolas_upshifts" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="upshifts" CDS 476073..476444 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651322, 9669336, 9763714, 12562800, 21421783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651322, 9669336, 9763714, 12562800, 21421783; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein glucose starvation induced" /protein_id="NP_388321.1" /db_xref="EnsemblGenomes-Gn:BSU04400" /db_xref="EnsemblGenomes-Tr:CAB12247" /db_xref="InterPro:IPR019626" /db_xref="SubtiList:BG10826" /db_xref="UniProtKB/Swiss-Prot:P26907" /translation="MADNNKMSREEAGRKGGETTSKNHDKEFYQEIGQKGGEATSKNH DKEFYQEIGEKGGEATSKNHDKEFYQEIGEKGGEATSENHDKEFYQEIGRKGGEATSK NHDKEFYQEIGSKGGNARNND*" /label="gsiB CDS" gene 476073..476444 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /label="gsiB gene" downshifts complement(476077) /Source="Nicolas_upshifts" /id="D206" /incds=0 /nref=1 /ntot=25 /MaxReadThrough="1.50212" /MaxDrop="4.6705" /score="-7.76438364" /energy="-14.2" /TU="NA" /idTUdmin="U346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 476461 /Source="Nicolas_upshifts" /id="D207" /incds=0 /nref=153 /ntot=219 /MaxReadThrough="3.75525" /MaxDrop="8.3301" /score="39.7307477" /energy="-16.6" /TU="U345" /idTUdmin="U345" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" upshifts complement(476495) /Source="Nicolas_upshifts" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(476498..476501) /Source="Nicolas_upshift_promotors" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 476523..476530 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476542..476561 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476549 /Source="Nicolas_upshifts" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="upshifts" CDS 476576..476917 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_388322.1" /db_xref="EnsemblGenomes-Gn:BSU04410" /db_xref="EnsemblGenomes-Tr:CAB12248" /db_xref="GOA:P96597" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR019780" /db_xref="SubtiList:BG12069" /db_xref="UniProtKB/Swiss-Prot:P96597" /translation="MSKMQNLLAIANEVKEKHANFSISEVNDHCVRLAVFTGEYDWHH HPDSDELFIVLEGELLIDFKDKETAVLKANDSLLIPKGTVHRTRSYVRTVNLCVEHKQ AETVIIEEQPC*" /label="ydbB CDS" gene 476576..476917 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /label="ydbB gene" CDS 476911..477270 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388323.1" /db_xref="EnsemblGenomes-Gn:BSU04420" /db_xref="EnsemblGenomes-Tr:CAB12249" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR032555" /db_xref="SubtiList:BG12070" /db_xref="UniProtKB/Swiss-Prot:P96598" /translation="MLIKKMICEVDAANAEAFAKAQSQWEALSHISGFIKQAGGWRKT IDEPLTAEIISVWENREAYDHFMENEHDSIYEENDQKAVILSIEVTVYEEDKPFVHDL LHNPDIRYEPNWTVLKA*" /label="ydbC CDS" gene 476911..477270 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /label="ydbC gene" S_feature complement(476973..477266) /Source="Nicolas_S_feature" /locus_tag="new_495406_495699_c" /HighExp="Etha, Salt, M9-stat, C30, Heat, Sw, B60, S8, C90, UNK1" /AntisenseName="ydbC" /AntisenseCor="0.16172626521480701" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S148" downshifts 477211 /Source="Nicolas_upshifts" /id="D208" /incds=0 /nref=2 /ntot=130 /MaxReadThrough="1.8663" /MaxDrop="2.67081" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 477255 /Source="Nicolas_upshifts" /id="D209" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="0.252220000000001" /MaxDrop="2.61185" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(477307..478128) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /EC_number="1.11.1.6" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15231799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative manganese-containing catalase" /protein_id="NP_388324.1" /db_xref="EnsemblGenomes-Gn:BSU04430" /db_xref="EnsemblGenomes-Tr:CAB12250" /db_xref="GOA:P80878" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR027407" /db_xref="SubtiList:BG12071" /db_xref="UniProtKB/Swiss-Prot:P80878" /translation="MFKHTKMLQHPAKPDRPDPLFAKKMQEILGGQFGEISVAMQYLF QGWNTRGNEKYKDLLMDTATEELGHVEMIATMIARLLEDAPLDQQEKAAEDPVIGSIL GGMNPHHAIVSGLGAMPESSTGVPWSGGYIVASGNLLADFRANLNAESQGRLQVARLF EMTDDKGVKDMLSFLLARDTMHQNQWLAAIKELEAQEGPVVPGTFPKALEKQEFSHQL INFSEGEVSAEQNWLNEKAPDGEAFEYVKEAKTFGEKPELKPAPPFVHNTLPGRE*" /label="ydbD CDS" gene complement(477307..478128) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /label="ydbD gene" downshifts complement(477311) /Source="Nicolas_upshifts" /id="D210" /incds=0 /nref=62 /ntot=214 /MaxReadThrough="4.23505" /MaxDrop="6.82771" /score="-6.55917314" /energy="-13.1" /TU="U348" /idTUdmin="U348" /TUdmin="-310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(478150..478168) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(478171) /Source="Nicolas_upshifts" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(478182..478188) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(478213..479265) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:1809844, 10708364, 11566984, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1809844, 10708364, 11566984, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane bound C4-dicarboxylate binding sensor protein" /protein_id="NP_388325.1" /db_xref="EnsemblGenomes-Gn:BSU04440" /db_xref="EnsemblGenomes-Tr:CAB12251" /db_xref="GOA:P96600" /db_xref="InterPro:IPR004682" /db_xref="InterPro:IPR018389" /db_xref="SubtiList:BG12072" /db_xref="UniProtKB/Swiss-Prot:P96600" /translation="MKSLLACLALMIAGIATALFIGFHDHTGNKKIVYDDDQEGLQDQ IVFKFSHVVAENTPKGLAANKFADLVNEKSGGKIKIEVFPNGSLYSDIEEIEALQNGD VQFIAPSTSKLGMLSPEWGVLDLPYAFTDYNAVKKGLNGSIGTQLFDSLKKNQLKGLA YWTNGFKQITTNQGPVKTPDDLKGQDLRIMQSDVIEDQFKLLGATPHQESFNSTFQLL ENNVVDGEENTISNIYSKKFYNVQDYLTISSHGYLGYAVMTDEHFWKAQTPETRRILT EAMKETTEWNETYAEQMNKEQLEEIKKNSAIHIYELSDKEKQEWMKRLDPVYRQYEPI FGRELIRELLELRKDS*" /label="dctB CDS" gene complement(478213..479265) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /label="dctB gene" promotor_-35 478525..478532 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 478547..479334 /Source="Nicolas_S_feature" /locus_tag="new_496980_497767" /HighExp="LBGstat, Diami, T-0.40H, T0.0H, T0.30H, Heat, UNK1, GM-0.1, MG 90, Fru" /AntisenseName="dctB" /AntisenseCor="0.64205060306327899" /AntisenseRegPval="-31.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S149" promotor_-10 478547..478566 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 478548 /Source="Nicolas_upshifts" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(479278..479297) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(479283) /Source="Nicolas_upshifts" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(479311..479318) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 479335..480942 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388326.1" /db_xref="EnsemblGenomes-Gn:BSU04450" /db_xref="EnsemblGenomes-Tr:CAB12252" /db_xref="GOA:P96601" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12073" /db_xref="UniProtKB/Swiss-Prot:P96601" /translation="MNKKKLSIRWKITILSYILVIFSFLIGGIVLIGNIQHTEERELK KRLMNTARTVSEMTEVKEALARKKQTEAVRHAVEEIRMINEADYIVVMDMNHIRYTHP VSTSIGKKSEGADEEAAFAEHIYFSEAKGEIGTAVRAFYPVKDQDLNQIGVVLVGKTL PGIADILLHLKRDIAFIVVLTLGFGLAGSFLLARHIKKQMFQLEPHEIVRMYEERTAT FHSMNEGVIAIDNRLVITIFNEKAKQIFEVQGDLIGKVIWEVLKDSRLPEIVERNKAV YNEEIRVSGKVIMSSRIPIVMKKKVIGAVAIFQDRTEAAKMAEELTGVRNFVEALRVQ NHEHMNKLHTIAGLIQLGKSEKALQLAFQASTEQENVTEFLHRSIQNDAAAGLLLSKI RRGRELGIAVHIDENSSLQQFPEHVDQHDIVVLLGNLIENAFGSFETVQSEDKRIDIS IEQTDDILAILIEDNGCGIEPTHMPRLYDKGFTVNKTGGTGYGLYLVKQIIDKGSGTI EVDSHAGQGTSFSIVFPMKGEEAQHGS*" /label="dctS CDS" gene 479335..480942 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /label="dctS gene" CDS 480932..481612 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388327.1" /db_xref="EnsemblGenomes-Gn:BSU04460" /db_xref="EnsemblGenomes-Tr:CAB12253" /db_xref="GOA:P96602" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12074" /db_xref="UniProtKB/Swiss-Prot:P96602" /translation="MARKEWKVLLIEDDPMVQEVNKDFITTVKGVTVCATAGNGEEGM KLIKEEQPDLVILDVYMPKKDGIKTLQEIRKQKLEVDVIVVSAAKDKETISLMLQNGA VDYILKPFKLERMRQALEKYKQYKQKIEANDTLSQEQLDAILNIPQQAVQDLPKGLNH FTMNEVTAFLKQQTASLSAEEVAKALGIARVTARRYLDYLEKTGIIKLDVQYGGVGRP VNRYVLKG*" /label="dctR CDS" gene 480932..481612 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /label="dctR gene" S_feature 481613..481687 /Source="Nicolas_S_feature" /locus_tag="new_500046_500120" /HighExp="Sw, Diami, Mt0, G150, BI, Lbstat, M40t45, Lbtran, Mal, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S150" promotor_-35 481654..481661 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 481676..481693 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 481689 /Source="Nicolas_upshifts" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="upshifts" CDS 481733..482998 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480; Product type t: transporter" /codon_start=1 /transl_table=11 /product="C4-dicarboxylate transport protein" /protein_id="NP_388328.1" /db_xref="EnsemblGenomes-Gn:BSU04470" /db_xref="EnsemblGenomes-Tr:CAB12254" /db_xref="GOA:P96603" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR023954" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12075" /db_xref="UniProtKB/Swiss-Prot:P96603" /translation="MKLFKNLTVQVITAVIIGVIVGLVWPDVGKEMKPLGDTFINAVK MVIAPIIFFTIVLGIAKMGDMKKVGKVGGKAFIYFEVVTTLALIIGLFVVNIMKPGAG LDYSKLEKGDVSQYTQNGGQGIDWIEFITHIVPSNMVDAFAKGDILQVLFFSILFGVG LAALGEKGKSVIDFFDKVSHVFFKIIGYIMRAAPIGAFGAMAYTIGHFGLDSIKPLAS LMMSVYITMFLFVFVALNIICKLYGFSLWNYLRFIKDELLIVLGTSSSESVLPRMMDK MERYGCSKSVVGLVIPTGYSFNLDGTSIYLSMATVFLAQVFGVDLSIGQQITIILVLM LTSKGAAGVTGSGFIVLASTLSALQVIPLEGLALLLGVDRFMSEGRAIVNLIGNGIAT IIVAKSENEFDEAKSIEAVEGMKKMKTAV*" /label="dctP CDS" gene 481733..482998 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /label="dctP gene" downshifts 482991 /Source="Nicolas_upshifts" /id="D211" /incds=0 /nref=175 /ntot=235 /MaxReadThrough="3.99042" /MaxDrop="7.04798" /score="45.0636559" /energy="-12.6" /TU="NA" /idTUdmin="U351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(483045) /Source="Nicolas_upshifts" /id="D212" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.588190000000001" /MaxDrop="3.06255" /score="19.3433396" /energy="-12.6" /TU="NA" /idTUdmin="U350" /TUdmin="-4818" /isTUend="FALSE" /label="downshifts" misc_feature 483082..483099 /Source="Nicolas_upshift_promotors" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 483084 /Source="Nicolas_upshifts" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 483146..484198 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388329.1" /db_xref="EnsemblGenomes-Gn:BSU04480" /db_xref="EnsemblGenomes-Tr:CAB12255" /db_xref="GOA:P96604" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG12076" /db_xref="UniProtKB/Swiss-Prot:P96604" /translation="MAALVKFFQHPGVRRFSIFVVLTGVLYLFKSMINLILLTFIFTF LMDRLELVVRQFVSQFFRVSQRVVITFLYMLLAVLLTVGGFVFYPVVAAQIQQLVKQI KHIAYHPDSIPFFDEITSVFGDINISSYVKEGFNVVYTYLADISTFGLQVVMALILSM FFLFEKKRLSEFMAKFKTSKLRVFYEEIAFFGSKFARTFGKVLEAQFIIALVNCILTF IALWIMHFPQLFGLSIMVFFLGLIPVAGVVISLIPLSIIAYSTGGGMYVLYIVLVIFA IHAIETYFLNPKLMSAKTELPIFFTFTVLIFSEHFFGIWGLIIGIPIFVFLLDILDVT NKEDRSKGPRENSDKK*" /label="ydbI CDS" gene 483146..484198 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /label="ydbI gene" S_feature 484199..484442 /Source="Nicolas_S_feature" /locus_tag="new_502632_502875" /HighExp="S8, S5, S6, LoTm, S7, S3, LBGstat, LBGexp, Paraq, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87223499999999998" /TUshortSig="Sig-" /TUshortPSig="0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S151" downshifts 484399 /Source="Nicolas_upshifts" /id="D213" /incds=0 /nref=6 /ntot=45 /MaxReadThrough="6.05001" /MaxDrop="3.52626" /score="17.6400305" /energy="-12.4" /TU="U352" /idTUdmin="U351" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" CDS 484475..485401 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding subunit)" /protein_id="NP_388330.1" /db_xref="EnsemblGenomes-Gn:BSU04490" /db_xref="EnsemblGenomes-Tr:CAB12256" /db_xref="GOA:P96605" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12077" /db_xref="UniProtKB/Swiss-Prot:P96605" /translation="MAEPILHIEGLDKKIGSKQILKQISMDVMEGEIIGLLGPNGSGK TTLIRIIVGLLKQNSGSVTISGFQHDTEFEKAMEAVGAIVENPEFYPYLTGWENLKHF ANMHKKIADERLDEVVERVGLTSAIHDKVKTYSLGMRQRLGIAQAILHRPKLLILDEP TNGLDPAGMKDFRDHIKELAEMEGTAVLFATHLLREVEDLCDRVIIIQKGEIKAEVSL QGTDQTTEKAIIEVQPQEKALNWLTGNQYQAESQDGTIVVEVAKENIPELNRSLVGQD LNVFSITPYTQSLEDEFIKATTAHQEEGEELV*" /label="ydbJ CDS" gene 484475..485401 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /label="ydbJ gene" CDS 485421..486161 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux ABC-transporter (permease subunit)" /protein_id="NP_388331.1" /db_xref="EnsemblGenomes-Gn:BSU04500" /db_xref="EnsemblGenomes-Tr:CAB12257" /db_xref="GOA:P96606" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12078" /db_xref="UniProtKB/Swiss-Prot:P96606" /translation="MKLFNRKVTLVSLILMAVFQFFMALIIKRIVISAGTDENFIGYL SYTPSLNILLQALTIVIAATIVSMEFDKKTIKFLLIRPVKRQKVFWSKLITVVMVSFY LYLAYYILALLFGLLFFGTSVTAESKTLLVNTLALIGSNWLEAVMMGLFGLLCSSLFR NSAVAVVVSFVVLYGASTLVQLMKLFENKWGSFLLFANTDFTQYRSGETALFSGMTPL FSIGILIIHAIFFIVVGWWCFCKRDVRV*" /label="ydbK CDS" gene 485421..486161 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /label="ydbK gene" misc_feature 486220..486239 /Source="Nicolas_upshift_promotors" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 486225 /Source="Nicolas_upshifts" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 486256..486591 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928292; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative glyco-prenyl flippase subunit" /protein_id="NP_388332.1" /db_xref="EnsemblGenomes-Gn:BSU04510" /db_xref="EnsemblGenomes-Tr:CAB12258" /db_xref="GOA:P96607" /db_xref="SubtiList:BG12079" /db_xref="UniProtKB/Swiss-Prot:P96607" /translation="MRNFITALPIVLLLGFSFVSFMFQFEHLVYFRLALGLFSLVGLY MIYKMKTGIRYFIIYLYASWIVLAAVTAFEEPIFSSFFFGGLVMTMGYLTYMLIYLGM KQDRDANPV*" /label="ydbL CDS" gene 486256..486591 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /label="ydbL gene" downshifts 486566 /Source="Nicolas_upshifts" /id="D214" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="5.33473" /MaxDrop="5.39081" /score="25.8152101" /energy="-18.4" /TU="U352,U353" /idTUdmin="U352" /TUdmin="-1177" /isTUend="FALSE" /label="downshifts" S_feature 486611..486680 /Source="Nicolas_S_feature" /locus_tag="new_505044_505113" /HighExp="ferm, nit, S2, S0, Gly, M0t45, M0t90, Lbstat, M/G, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.99, 0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S152" promotor_-35 486646..486653 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 486667..486686 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 486681 /Source="Nicolas_upshifts" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 486719..487864 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA dehydrogenase" /protein_id="NP_388333.1" /db_xref="EnsemblGenomes-Gn:BSU04520" /db_xref="EnsemblGenomes-Tr:CAB12259" /db_xref="GOA:P96608" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013107" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG12080" /db_xref="UniProtKB/Swiss-Prot:P96608" /translation="MSLFIQNDQQRQWMEKIGRIADEFQQTAAEDDEQGRFPAEKIQK LRDAGYTALTLPASHGGGGISVYDMLLFQERLARGDAPTALSIGWHLSVIGELGEGNS WDEDVFAFVAKEVQNGAVINRAATEAKTGSPTRGGRPGTHAVKKDGKWAVNGRKTFTT MSQALDYFLVTAWIEDKQTTGVFLIHKDDPGLSIEETWDMMAMRATGSHDLVLNEVML DENKLVELLQGPRGAKPNGWLLHIPAIYLGVAQAARDYAVQFASEYSPNSLNGPIKNV PAVQQRTGEMELELLNARHFLFHIAQLYDDPVRRPHLTSELGAAKHIVTNAALSVVDK AMRIVGAKSLERTNPLQRYYRDVRAGLHNPPMDDAVIHKLAAEAFES*" /label="ydbM CDS" gene 486719..487864 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /label="ydbM gene" downshifts 487846 /Source="Nicolas_upshifts" /id="D215" /incds=0 /nref=13 /ntot=123 /MaxReadThrough="2.90782" /MaxDrop="4.20573" /score="9.48525091" /energy="-7" /TU="NA" /idTUdmin="U353" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(487889..488068) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /experiment="publication(s) with functional evidences, PMID:12354229, 16428414, 18697947, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16428414, 18697947, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="NP_388334.1" /db_xref="EnsemblGenomes-Gn:BSU04530" /db_xref="EnsemblGenomes-Tr:CAB12260" /db_xref="GOA:P96609" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG12081" /db_xref="UniProtKB/Swiss-Prot:P96609" /translation="MNTNMSGGRRSMPKRKVKTYQQLIQENKEAIMGNPKLMNVIYDR IDRKHQKNLQEQNNT*" /label="fbpB CDS" gene complement(487889..488068) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /label="fbpB gene" downshifts complement(487907) /Source="Nicolas_upshifts" /id="D216" /incds=0 /nref=158 /ntot=207 /MaxReadThrough="2.35872" /MaxDrop="6.38199" /score="26.3317207" /energy="-7" /TU="NA" /idTUdmin="U355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(488022..488186) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513944.1" /db_xref="EnsemblGenomes-Gn:BSU04536" /db_xref="EnsemblGenomes-Tr:CCQ48594" /db_xref="InterPro:IPR025072" /db_xref="UniProtKB/TrEMBL:L8ECQ9" /translation="MTPQSAEIRKKQLIHLLIQNGIYKKSKRHLYELSLTELESEYKH VRRAPEHAEA*" /label="fbpA CDS" gene complement(488022..488186) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /label="fbpA gene" S_feature complement(488069..488237) /Source="Nicolas_S_feature" /locus_tag="new_506502_506670_c" /HighExp="B60, nit, B36, Lbexp, GM 15, GM 10, dia0, S2, GM 25, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99141199999999996" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S153" promotor_-10 complement(488229..488248) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(488239) /Source="Nicolas_upshifts" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(488263..488270) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 488378..488383 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488399..488417 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 488403 /Source="Nicolas_upshifts" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="upshifts" CDS 488433..489305 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cation efflux system" /protein_id="NP_388335.1" /db_xref="EnsemblGenomes-Gn:BSU04540" /db_xref="EnsemblGenomes-Tr:CAB12261" /db_xref="GOA:P96610" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12082" /db_xref="UniProtKB/Swiss-Prot:P96610" /translation="MERTENLKKGEKGALLNIFAYVILAVVKLVIGILYHSEALRADG LNNGTDIVASVAVLIGLRISQRPADSDHPYGHYRAETISSLVASFIMMAVGIEVLIGG GKAIAGGTTETPNLIAAWTALGSAVFMYGIYLYNKRLAASIKSSALMAAAKDSRSDAF VSAGAFIGVFSSQLKLPWVDPVTAFIIGIIICKTAWDIFKDASHSLTDGFHLKDLEPY KQTVGRIENVHRLKDVKARYLGSTVHIEMVITVDPKLTVEEGHGVADEVEDKIKHEHD VTHVHVHVEPDDIK*" /label="ydbO CDS" gene 488433..489305 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /label="ydbO gene" promotor_-35 488669..488678 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488691..488706 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 488694 /Source="Nicolas_upshifts" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(489250..489319) /Source="Nicolas_S_feature" /locus_tag="new_507683_507752_c" /HighExp="LPhT, dia15, dia5, Diami, Etha, Lbtran, LBGtran, LBGstat, Mt0, M0t45" /AntisenseName="ydbO" /AntisenseCor="0.18463882527998399" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S154" downshifts complement(489293) /Source="Nicolas_upshifts" /id="D217" /incds=0 /nref=145 /ntot=242 /MaxReadThrough="3.07579" /MaxDrop="6.00116" /score="9.69023537" /energy="-12.3" /TU="U359" /idTUdmin="U359" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 489306..489655 /Source="Nicolas_S_feature" /locus_tag="new_507739_508088" /HighExp="Salt, Paraq, G135, ferm, Oxctl, T-0.40H, G150, Lbexp, T3.0H, T2.30H" /AntisenseName="ydbP" /AntisenseCor="-0.27800721625230801" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S155" CDS complement(489320..489640) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388336.1" /db_xref="EnsemblGenomes-Gn:BSU04550" /db_xref="EnsemblGenomes-Tr:CAB12262" /db_xref="GOA:P96611" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12083" /db_xref="UniProtKB/Swiss-Prot:P96611" /translation="MKKITTNEQFNELIQSDKEIIVKFYADWCPDCTRMNMFIGDILE EYNQNDWYELNKDELPDLAEKYQVMGIPSLLIFKNGEKTAHLHSANAKTPEEVTEFLS EHIS*" /label="ydbP CDS" gene complement(489320..489640) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /label="ydbP gene" promotor_-35 489636..489640 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 489649..489663 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 489657..489814 /Source="Nicolas_S_feature" /locus_tag="new_508090_508247" /HighExp="Lbexp, dia0, LBGexp, H2O2, Paraq, Oxctl, G180, Salt, M0t45, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigWXY" /TUshortPSig="0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S156" upshifts 489657 /Source="Nicolas_upshifts" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(489661..489680) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(489676) /Source="Nicolas_upshifts" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(489694..489701) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-35" CDS 489815..490879 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /EC_number="6.3.2.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8662022, 12682299, 22407814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine ligase A" /protein_id="NP_388337.1" /db_xref="EnsemblGenomes-Gn:BSU04560" /db_xref="EnsemblGenomes-Tr:CAB12263" /db_xref="GOA:P96612" /db_xref="InterPro:IPR000291" /db_xref="InterPro:IPR005905" /db_xref="InterPro:IPR011095" /db_xref="InterPro:IPR011127" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11932" /db_xref="UniProtKB/Swiss-Prot:P96612" /translation="MYGGKSAEHNVSLQTALAVIKALNTEKFDIHPIYITEKGEWVRG ARLTEPVSNVKMLQFEQGGSAFSPAALNQEMFPQEASQQNEAIDVVFPLLHGPNGEDG TIQGMLELLNIPYVGNGVLASSAGMDKVVMKHLFAQVGLAQAKYAAFLKKDWTRSPKE SCEEVEQELGYPCFVKPANLGSSVGISKCRNREELQKAFELAFQYDRKVVVEEGINGR EIEIGVLGNDDPKCSVVGEIAPKTDFYDYKAKYEDGDTDLMIPAIVTDEEYATISDMA IKAFKAIDGSGLVRADFFLTADGEVLINEVNTMPGFTPFSMFPLLWKEAGVEYADLIE QLVELAKERHAEKQLIKHTF*" /label="ddlA CDS" gene 489815..490879 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /label="ddlA gene" downshifts 490867 /Source="Nicolas_upshifts" /id="D218" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="5.68418" /MaxDrop="2.53103" /score="3.92144467" /energy="-9.6" /TU="U357,U358" /idTUdmin="U356" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS 490951..492324 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /EC_number="6.3.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanine ligase" /protein_id="NP_388338.1" /db_xref="EnsemblGenomes-Gn:BSU04570" /db_xref="EnsemblGenomes-Tr:CAB12264" /db_xref="GOA:P96613" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005863" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG12084" /db_xref="UniProtKB/Swiss-Prot:P96613" /translation="MIKRTVKNIAEMVKGTLANPQYEQTVIHGVATDTRKLEQHQLFI PLKGERFDGHSFVEQAFEAGVAAVLWDRSVPNPPENHAVILVDDTLTALQQLAKAYLQ ELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEI AVLEMGMSAKGEIDLLSRLANPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKED GVLIYIGDEPLLQNAYSCQTKTYGTGTHNDYQLQDVSQSEEGTHFTIKGIENTFFIPI LGKHNVMNAMAAIAAGAYFGIAPEDAAKGLSGLKVTGMRLELIKTDSGLSIINDAYNA SPTSMKAAIQLTESLEGYGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTYG KLGAFIAEGALKHFEKDRVSHYTEKKDLLQAVKENASKGDLILFKASRGMKLEEIVKD LIESPLS*" /label="murF CDS" gene 490951..492324 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /label="murF gene" promotor_-35 492355..492361 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 492375..492386 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 492385 /Source="Nicolas_upshifts" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 492428..492447 /Source="Nicolas_upshift_promotors" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 492429..492603 /Source="Nicolas_S_feature" /locus_tag="new_510862_511036" /HighExp="Cold, ferm, nit, G135, S5, LBGexp, G150, S8, S7, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.76694499999999999" /TUshortSig="SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S157" upshifts 492429 /Source="Nicolas_upshifts" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 492571..492578 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 492593..492612 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 492605..492672 /Source="Nicolas_S_feature" /locus_tag="new_511038_511105" /HighExp="Cold, G150, T-3.40H, HPh, Salt, LPh, G180, G135, Oxctl, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S158" upshifts 492605 /Source="Nicolas_upshifts" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="upshifts" CDS 492724..494208 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16352840, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352840, 27965645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_388339.2" /db_xref="EnsemblGenomes-Gn:BSU04580" /db_xref="EnsemblGenomes-Tr:CAB12265" /db_xref="GOA:P96614" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030880" /db_xref="SubtiList:BG12085" /db_xref="UniProtKB/Swiss-Prot:P96614" /translation="MTITFQDFNLSSDLMKAINRMGFEEATPIQAQTIPLGLSNKDVI GQAQTGTGKTAAFGIPLVEKINPESPNIQAIVIAPTRELAIQVSEELYKIGQDKRAKV LPIYGGQDIGRQIRALKKNPNIIVGTPGRLLDHINRRTIRLNNVNTVVMDEADEMLNM GFIDDIESILSNVPSEHQTLLFSATMPAPIKRIAERFMTEPEHVKVKAKEMTVSNIQQ FYLEVQERKKFDTLTRLLDIQSPELAIVFGRTKRRVDELAEALNLRGYAAEGIHGDLT QAKRMVALRKFKEGAIEVLVATDVAARGLDISGVTHVYNFDVPQDPESYVHRIGRTGR AGKTGMAMTFITPREKSMLRAIEQTTKRKMDRMKEPTLDEALEGQQQVTVERLRTTIS ENNLNFYMTAAAELLEDHDAVTVVAAAIKMATKEPDDTPVRLTDEAPMVSKRYKNQRS SKRRDGQGGGYRGGKGKSNNRSSYDKKRSNDRRSSGDRRQKKSY*" /label="cshA CDS" gene 492724..494208 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /label="cshA gene" downshifts 494201 /Source="Nicolas_upshifts" /id="D219" /incds=0 /nref=309 /ntot=313 /MaxReadThrough="1.91428" /MaxDrop="8.13079" /score="26.104757" /energy="-13.1" /TU="NA" /idTUdmin="U358" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" S_feature 494321..494380 /Source="Nicolas_S_feature" /locus_tag="new_512754_512813" /HighExp="Etha, LBGexp, G180, Cold, Lbtran, dia0, G150, BMM, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S159" promotor_-35 494321..494330 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 494323 /Source="Nicolas_upshifts" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 494342..494357 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 494381..494860 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388340.1" /db_xref="EnsemblGenomes-Gn:BSU04590" /db_xref="EnsemblGenomes-Tr:CAB12266" /db_xref="GOA:P96615" /db_xref="InterPro:IPR005182" /db_xref="SubtiList:BG12086" /db_xref="UniProtKB/Swiss-Prot:P96615" /translation="MREQPKNQISPDGLKVWRLQEIIISAVCLLIVIAVAVLSYYFHW PYWISGVLGAVWLLGSIVTVFIIPKVRHKVWRYEVHEHEIDIQSGIFVVTRVIVPMVR VQHVDTSQGPLLKKYNLATVKISTAATVHSIPALEMEEADRLRDSISRLARVTDDDV* " /label="ydbS CDS" gene 494381..494860 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /label="ydbS gene" CDS 494850..496331 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388341.1" /db_xref="EnsemblGenomes-Gn:BSU04600" /db_xref="EnsemblGenomes-Tr:CAB12267" /db_xref="GOA:P96616" /db_xref="InterPro:IPR005182" /db_xref="InterPro:IPR014529" /db_xref="SubtiList:BG12087" /db_xref="UniProtKB/Swiss-Prot:P96616" /translation="MMSEPKRLHPVAVILNLCHTIIQTIKNIILPFFFVYIVNSNHTV RFYGAIALGVLFIWLVAASIIKWRRFTYRIEDDEFRIEEGLFVTKKRYISIDRIQTMN TSAGLVQQIFKLVKLQIETAGGGKEAEAVLSAISVEEAERIKEAVFKKKAQRRENELD EERLEAEEELDPSVEVQEHYRMNAKELLMAASTSGGIGVIISAVFALISQLDEVLPMD WLFDKFSFLQHASIGIYAVLIFIGLFIAWIFSIAGMMFRYANFQIIKKEQELVISRGI IEKHQVTIPLRKIQAIKIKENIIRQLFGFVTVSIVSAGGGDREKEEGALTILFPMIHK KKLPHMLRTFTPEYTLEENCRRLPRRALKRYLFRSVIFSLFLIIPLCIFFQPWGYLSV ILLPIELLFGYLAYKEAAWTINGDRLQLTSRFIGRTTAIVLKKRMQVCKFSQSYFQKK GRLYTISTSVKSSSHMEELTVRDVGEEDAAFILKWYSYEKADG*" /label="ydbT CDS" gene 494850..496331 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /label="ydbT gene" downshifts 496301 /Source="Nicolas_upshifts" /id="D220" /incds=0 /nref=6 /ntot=162 /MaxReadThrough="4.90913" /MaxDrop="3.0931" /score="48.2239319" /energy="-17.1" /TU="U363" /idTUdmin="U364" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature 496346..496673 /Source="Nicolas_S_feature" /locus_tag="new_514779_515106" /HighExp="Salt, T0.30H, G135, T1.0H, T1.30H, G150, G180, Oxctl, T-0.40H, aero" /AntisenseName="ydcA" /AntisenseCor="-0.25636523135066602" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S160" downshifts complement(496355) /Source="Nicolas_upshifts" /id="D221" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="0.258529999999999" /MaxDrop="3.15455" /score="-3.74867023" /energy="-8.8" /TU="NA" /idTUdmin="U365" /TUdmin=220 /isTUend="FALSE" /label="downshifts" CDS complement(496583..497182) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /EC_number="3.4.21.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15616571, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhomboid protease" /protein_id="NP_388342.1" /db_xref="EnsemblGenomes-Gn:BSU04610" /db_xref="EnsemblGenomes-Tr:CAB12268" /db_xref="GOA:P96617" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG12088" /db_xref="UniProtKB/Swiss-Prot:P96617" /translation="MFIRTENFQTFIRLYPVVTFILALQAVLWLFFSLPAHSVVLWRD TVTGYNLGVANGEWWRLITPILLHAGFTHLLFNSMSIFLFAPALERMLGKARFLLVYA GSGIIGNIGTYVTEPLDYVHVGASGAIFGLFGVYLFMVLFRNELIGQEHSKMIITLLA FAVLMSFINSNINMMAHLFGLCGGFLLSFLCVQKKERRY*" /label="ydcA CDS" gene complement(496583..497182) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /label="ydcA gene" promotor_-35 496643..496648 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 496661..496680 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 496675..497276 /Source="Nicolas_S_feature" /locus_tag="new_515108_515709" /HighExp="Salt, G135, G150, T0.30H, G180, T1.0H, T1.30H, H2O2, Paraq, Oxctl" /AntisenseName="ydcA" /AntisenseCor="-0.11975373672841701" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S161" upshifts 496675 /Source="Nicolas_upshifts" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(497206..497225) /Source="Nicolas_upshift_promotors" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(497217) /Source="Nicolas_upshifts" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="upshifts" CDS 497277..497642 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /EC_number="2.7.8.7" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11489886, 11525165, 11867633, 12682299, 12926246, 15955059, 16597923; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="holo-acyl carrier protein synthase (phosphopantetheinyl transferase)" /protein_id="NP_388343.1" /db_xref="EnsemblGenomes-Gn:BSU04620" /db_xref="EnsemblGenomes-Tr:CAB12269" /db_xref="GOA:P96618" /db_xref="InterPro:IPR002582" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1F7L" /db_xref="PDB:1F7T" /db_xref="PDB:1F80" /db_xref="SubtiList:BG12089" /db_xref="UniProtKB/Swiss-Prot:P96618" /translation="MIYGIGLDITELKRIASMAGRQKRFAERILTRSELDQYYELSEK RKNEFLAGRFAAKEAFSKAFGTGIGRQLSFQDIEIRKDQNGKPYIICTKLSQAAVHVS ITHTKEYAAAQVVIERLSS*" /label="acpS CDS" gene 497277..497642 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /label="acpS gene" promotor_-35 497645..497650 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-35" S_feature 497666..497807 /Source="Nicolas_S_feature" /locus_tag="new_516099_516240" /HighExp="S3, S4, BT, LoTm, S5, T5.0H, M9-stat, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S162" promotor_-10 497666..497684 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-10" upshifts 497666 /Source="Nicolas_upshifts" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="upshifts" CDS 497808..498824 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388344.2" /db_xref="EnsemblGenomes-Gn:BSU04630" /db_xref="EnsemblGenomes-Tr:CAB12270" /db_xref="GOA:P96619" /db_xref="InterPro:IPR029046" /db_xref="SubtiList:BG12090" /db_xref="UniProtKB/Swiss-Prot:P96619" /translation="MKKVRKSFVLLLTGLLAVLILSACGQKTQQDIVAGLDEKAKEYT SYKAKAKMTIETGSEPQVYNVEIWHKKPSLYRVYLENPKKDQNQVILRNENGVFVLTP SLNKSFRFQSDWPNNSSQVYLFESLVKDVQNDSDAVFTAKEKKYVFETKTNYQHNKML PTQEITFNKKDMSPSSVKVMDTDRKVMVKVEFSSFEFNKQFDKESFDEKKNMTLSQMD VATSAKPSDTFAVKTPLELPLGVKLLEEKDISTEDGKRIIMTYGGEKSFTLIQEKAQI AKASSSVTLNGEPVNLGYTIGALSDASLSWTYDGVDYLLSSKDLSKEEMVTVAKSMQG QSSK*" /label="ydcC CDS" gene 497808..498824 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /label="ydcC gene" downshifts 498809 /Source="Nicolas_upshifts" /id="D222" /incds=0 /nref=193 /ntot=256 /MaxReadThrough="3.39815" /MaxDrop="6.13946" /score="22.0391647" /energy="-9.5" /TU="U366" /idTUdmin="U363" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 498869..498876 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 498890..498909 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 498897 /Source="Nicolas_upshifts" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 498939..500108 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /EC_number="5.1.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2835089, 12682299, 15043879, 18399999, 25227915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine racemase" /protein_id="NP_388345.1" /db_xref="EnsemblGenomes-Gn:BSU04640" /db_xref="EnsemblGenomes-Tr:CAB12271" /db_xref="GOA:P10725" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10950" /db_xref="UniProtKB/Swiss-Prot:P10725" /translation="MSTKPFYRDTWAEIDLSAIKENVSNMKKHIGEHVHLMAVVKANA YGHGDAETAKAALDAGASCLAVAILDEAISLRKKGLKAPILVLGAVPPEYVAIAAEYD VTLTGYSVEWLQEAARHTKKGSLHFHLKVDTGMNRLGVKTEEEVQNVMAILDRNPRLK CKGVFTHFATADEKERGYFLMQFERFKELIAPLPLKNLMVHCANSAAGLRLKKGFFNA VRFGIGMYGLRPSADMSDEIPFQLRPAFTLHSTLSHVKLIRKGESVSYGAEYTAEKDT WIGTVPVGYADGWLRKLKGTDILVKGKRLKIAGRICMDQFMVELDQEYPPGTKVTLIG RQGDEYISMDEIAGRLETINYEVACTISSRVPRMFLENGSIMEVRNPLLQVNISN*" /label="alrA CDS" gene 498939..500108 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /label="alrA gene" promotor_-35 500037..500042 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500057..500075 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500063 /Source="Nicolas_upshifts" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 500138..500141 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500157..500176 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500158 /Source="Nicolas_upshifts" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 500224..500505 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antitoxin EndoAI" /protein_id="NP_388346.1" /db_xref="EnsemblGenomes-Gn:BSU04650" /db_xref="EnsemblGenomes-Tr:CAB12272" /db_xref="GOA:P96621" /db_xref="InterPro:IPR002145" /db_xref="InterPro:IPR010985" /db_xref="InterPro:IPR013321" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12091" /db_xref="UniProtKB/Swiss-Prot:P96621" /translation="MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAY VSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAECEAETTVERLVSGG*" /label="ndoAI CDS" gene 500224..500505 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /label="ndoAI gene" CDS 500510..500860 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 21897862, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 21897862, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease toxin" /protein_id="NP_388347.1" /db_xref="EnsemblGenomes-Gn:BSU04660" /db_xref="EnsemblGenomes-Tr:CAB12273" /db_xref="GOA:P96622" /db_xref="InterPro:IPR003477" /db_xref="InterPro:IPR011067" /db_xref="PDB:1NE8" /db_xref="PDB:4MDX" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12092" /db_xref="UniProtKB/Swiss-Prot:P96622" /translation="MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIV AAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQIRTIDKQRLTDKITHLDDEMMDK VDEALQISLALIDF*" /label="ndoA CDS" gene 500510..500860 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /label="ndoA gene" S_feature complement(500650..501126) /Source="Nicolas_S_feature" /locus_tag="new_519083_519559_c" /HighExp="Etha, Gly, Sw, S8, C30, S6, LBGstat, T0.30H, S7, Salt" /AntisenseName="ndoA" /AntisenseCor="-0.36117231948253697" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigK" /TUshortPSig="1, 1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S163" downshifts complement(500693) /Source="Nicolas_upshifts" /id="D223" /incds=1 /nref=6 /ntot=171 /MaxReadThrough="3.51096" /MaxDrop="3.79912" /score="-8.86444162" /energy="-10.2" /TU="U372" /idTUdmin="U371" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts 500840 /Source="Nicolas_upshifts" /id="D224" /incds=0 /nref=143 /ntot=254 /MaxReadThrough="5.57908" /MaxDrop="5.74865" /score="29.7721113" /energy="-8.9" /TU="U367,U368,U369" /idTUdmin="U366" /TUdmin=799 /isTUend="FALSE" /label="downshifts" promotor_-35 500894..500901 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500915..500934 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500923 /Source="Nicolas_upshifts" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 500975..501799 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome); positive regulation of sigma(B) activity in response to salt and heat stress" /protein_id="NP_388348.1" /db_xref="EnsemblGenomes-Gn:BSU04670" /db_xref="EnsemblGenomes-Tr:CAB12274" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR014792" /db_xref="InterPro:IPR036513" /db_xref="PDB:2BNL" /db_xref="SubtiList:BG11090" /db_xref="UniProtKB/Swiss-Prot:P42409" /translation="MMSNQTVYQFIAENQNELLQLWTDTLKELSEQESYQLTDQVYEN ISKEYIDILLLSVKDENAAESQISELALRAVQIGLSMKFLATALAEFWKRLYTKMNDK RLPDQESTELIWQIDRFFSPINTEIFNQYSISWEKTVSLQKIALQELSAPLIPVFENI TVMPLVGTIDTERAKRIMENLLNGVVKHRSQVVLIDITGVPVVDTMVAHHIIQASEAV RLVGAKCLLAGIRPEIAQTIVNLGIDLSQVITKNTLQKGIQTALEMTDRKIVSLGE*" /label="rsbRA CDS" gene 500975..501799 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /label="rsbRA gene" promotor_-10 complement(501109..501127) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(501126) /Source="Nicolas_upshifts" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(501128..501727) /Source="Nicolas_S_feature" /locus_tag="new_519561_520160_c" /HighExp="Etha, Sw, Gly, S6, S8, S7, B60, Salt, BT, M9-stat" /AntisenseName="rsbRA" /AntisenseCor="-0.53924606340364201" /AntisenseRegPval="-21" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S164" promotor_-35 complement(501141..501148) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(501716..501734) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(501727) /Source="Nicolas_upshifts" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(501729..502317) /Source="Nicolas_S_feature" /locus_tag="new_520162_520750_c" /HighExp="S6, S8, S7, BT, C30, S5, G135, C90, Gly, Fru" /AntisenseName="rsbS" /AntisenseCor="-0.57706416777859804" /AntisenseRegPval="-24.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S165" promotor_-35 complement(501748..501754) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 501804..502169 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 23320651, 28271471; Product type f : factor" /codon_start=1 /transl_table=11 /product="antagonist of RsbT" /protein_id="NP_388349.1" /db_xref="EnsemblGenomes-Gn:BSU04680" /db_xref="EnsemblGenomes-Tr:CAB12275" /db_xref="GOA:P42410" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11091" /db_xref="UniProtKB/Swiss-Prot:P42410" /translation="MRHPKIPILKLYNCLLVSIQWELDDQTALTFQEDLLNKIYETGA NGVVIDLTSVDMIDSFIAKVLGDVITMSKLMGAKVVLTGIQPAVAVTLIELGIALEEI ETALDLEQGLETLKRELGE*" /label="rsbS CDS" gene 501804..502169 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /label="rsbS gene" CDS 502173..502574 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine-threonine kinase; controlsthe activity of the anxiosome (stressosome)" /protein_id="NP_388350.1" /db_xref="EnsemblGenomes-Gn:BSU04690" /db_xref="EnsemblGenomes-Tr:CAB12276" /db_xref="GOA:P42411" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11092" /db_xref="UniProtKB/Swiss-Prot:P42411" /translation="MNDQSCVRIMTEWDIVAARQLGRNVAKELGFGTVDQARITTAIS ELARNIYLYAGKGQIGIEQVADRGKKGLKIIAEDQGPGIPDIRKVMEDGFSTSGGLGA GLPGVKRLMDEFSLNSVAGEGTEIQAIKWLR*" /label="rsbT CDS" gene 502173..502574 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /label="rsbT gene" promotor_-10 complement(502315..502334) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(502332) /Source="Nicolas_upshifts" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(502348..502357) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 502586..503593 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 17303566, 21979936, 28461450" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 17303566, 21979936, 28461450; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine phosphatase; controls the activity of the anxiosome (stressosome)" /protein_id="NP_388351.1" /db_xref="EnsemblGenomes-Gn:BSU04700" /db_xref="EnsemblGenomes-Tr:CAB12277" /db_xref="GOA:P40399" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014787" /db_xref="InterPro:IPR017944" /db_xref="InterPro:IPR036457" /db_xref="PDB:1W53" /db_xref="PDB:2J6Y" /db_xref="PDB:2J6Z" /db_xref="PDB:2J70" /db_xref="SubtiList:BG11057" /db_xref="UniProtKB/Swiss-Prot:P40399" /translation="MDFREVIEQRYHQLLSRYIAELTETSLYQAQKFSRKTIEHQIPP EEIISIHRKVLKELYPSLPEDVFHSLDFLIEVMIGYGMAYQEHQTLRGIQQEIKSEIE IAANVQQTLLGTKVPQEEALDIGAISVPAKQMSGDYYHFVKDKESINIAIADVIGKGI PAALCMSMIKYAMDSLPETGIHPSQVLKNLNRVVEQNVDASMFITMFYANYNMDKHQF TYASAGHEPGFYYSQKDNTFYDLEAKGLVLGISQDYDYKQFDQHLEKGDMIVLFSDGV TECRTENGFLERPDLQKLIEEHMCSSAQEMVKNIYDSLLKLQDFQLHDDFTLIVLRRK V*" /label="rsbU CDS" gene 502586..503593 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /label="rsbU gene" promotor_-35 503587..503593 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 503608..503626 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 503614 /Source="Nicolas_upshifts" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 503655..503984 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677; Product type f: factor" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of RsbW)" /protein_id="NP_388352.1" /db_xref="EnsemblGenomes-Gn:BSU04710" /db_xref="EnsemblGenomes-Tr:CAB12278" /db_xref="GOA:P17903" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG10733" /db_xref="UniProtKB/Swiss-Prot:P17903" /translation="MNINVDVKQNENDIQVNIAGEIDVYSAPVLREKLVPLAEQGADL RICLKDVSYMDSTGLGVFVGTFKMVKKQGGSLKLENLSERLIRLFDITGLKDIIDISA KSEGGVQ*" /label="rsbV CDS" gene 503655..503984 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /label="rsbV gene" CDS 503981..504463 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 21979936, 27977677; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine kinase and anti-sigma factor (inhibitory sigma-B binding protein)" /protein_id="NP_388353.1" /db_xref="EnsemblGenomes-Gn:BSU04720" /db_xref="EnsemblGenomes-Tr:CAB12279" /db_xref="GOA:P17904" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010193" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10734" /db_xref="UniProtKB/Swiss-Prot:P17904" /translation="MKNNADYIEMKVPAQPEYVGIIRLTLSGVASRMGYTYDEIEDLK IAVSEACTNAVQHAYKEDKNGEVSIRFGVFEDRLEVIVADEGDSFDFDQKQQDLGPYT PSHTVDQLSEGGLGLYLMETLMDEVRVQNHSGVTVAMTKYLNGERVDHDTTIKNYETN *" /label="rsbW CDS" gene 503981..504463 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /label="rsbW gene" CDS 504429..505217 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-37 factor (sigma(B))" /protein_id="NP_388354.2" /db_xref="EnsemblGenomes-Gn:BSU04730" /db_xref="EnsemblGenomes-Tr:CAB12280" /db_xref="GOA:P06574" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014288" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10735" /db_xref="UniProtKB/Swiss-Prot:P06574" /translation="MTQPSKTTKLTKDEVDRLISDYQTKQDEQAQETLVRVYTNLVDM LAKKYSKGKSFHEDLRQVGMIGLLGAIKRYDPVVGKSFEAFAIPTIIGEIKRFLRDKT WSVHVPRRIKELGPRIKMAVDQLTTETQRSPKVEEIAEFLDVSEEEVLETMEMGKSYQ ALSVDHSIEADSDGSTVTILDIVGSQEDGYERVNQQLMLQSVLHVLSDREKQIIDLTY IQNKSQKETGDILGISQMHVSRLQRKAVKKLREALIEDPSMELM*" /label="sigB CDS" gene 504429..505217 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /label="sigB gene" CDS 505217..505816 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine phosphatase" /protein_id="NP_388355.1" /db_xref="EnsemblGenomes-Gn:BSU04740" /db_xref="EnsemblGenomes-Tr:CAB12281" /db_xref="GOA:P17906" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR036457" /db_xref="PDB:3W40" /db_xref="PDB:3W41" /db_xref="PDB:3W42" /db_xref="PDB:3W43" /db_xref="PDB:3W44" /db_xref="PDB:3W45" /db_xref="SubtiList:BG10736" /db_xref="UniProtKB/Swiss-Prot:P17906" /translation="MIQVEENEHIQTLVYQLNKEGKSICGDSFFMKADDKELICAVAD GLGSGSLANESSAAIKDLVENYASEDVESIIERCNQAMKNKRGATASILKINFEQRQF TYCSVGNVRFILHSPSGESFYPLPISGYLSGKPQKYKTHTATYEKGSKFIIHTDGLNV PDIRSHLKKGQSVEEISNSLKMYTTSRKDDLTYILGQLS*" /label="rsbX CDS" gene 505217..505816 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /label="rsbX gene" downshifts 505802 /Source="Nicolas_upshifts" /id="D225" /incds=0 /nref=267 /ntot=278 /MaxReadThrough="2.46753" /MaxDrop="7.92167" /score="1.26147577" /energy="-6" /TU="NA" /idTUdmin="U369" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 505860..505866 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 505881..505900 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" Polymorphism join(505889,505891) /Source="geneious" /ID="SNP_BsDelta6_524323_524323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="A -> C" /Codon_Change /Coverage=183 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="BSU_04745_promoter_down_mutation" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 505893 /Source="Nicolas_upshifts" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 505927..506043 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513945.1" /translation="MWNYEYTAIADVDVGKPGTVIRKQKQWINGRRVLHQIL*" /label="hypothetical protein CDS" gene 505927..506043 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /label="gene" CDS 506059..506352 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388356.1" /db_xref="EnsemblGenomes-Gn:BSU04750" /db_xref="EnsemblGenomes-Tr:CAB12282" /db_xref="SubtiList:BG12093" /db_xref="UniProtKB/Swiss-Prot:P96623" /translation="MERKEHCFCKEKQFSYGLSMWRNIGRFLSWSTCPHSNVIMEFFH VLQKQKEDLCITYGIVLEGAEAKKWGEIIGTELSKDMPTAVSRLVHLYGGVIK*" /label="ydcF CDS" gene 506059..506352 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /label="ydcF gene" promotor_-35 506320..506328 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 506340..506359 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 506349..506789 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388357.1" /db_xref="EnsemblGenomes-Gn:BSU04760" /db_xref="EnsemblGenomes-Tr:CAB12283" /db_xref="InterPro:IPR002740" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR022996" /db_xref="SubtiList:BG12094" /db_xref="UniProtKB/Swiss-Prot:P96624" /translation="MNTNYWIGVVSEQHVLKGAAGGFAQLCHGKKAPLAKMKEGDWLI YYSPRDAYPDGKLLRSFTAIGKVKSGNIYPYQMAPNFIPYRLDIDYYPCHKIGFYDIK SKLEFVQETKHLGFLFRRGHFEISKKDFLTIAQAMGVNISGMAL*" /label="ydcG CDS" gene 506349..506789 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /label="ydcG gene" upshifts 506355 /Source="Nicolas_upshifts" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(506588..509643) /Source="Nicolas_S_feature" /locus_tag="new_525021_528076_c" /HighExp="S6, S8, S7, S5, B36, S4, B60, BT, Pyr, C30" /AntisenseName="ydcI" /AntisenseCor="-0.61304426345041496" /AntisenseRegPval="-28.4" /CDS_PredictionProba="0.40759499999999999" /TUshortSig="SigK" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S166" CDS 506773..507216 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12088660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388358.1" /db_xref="EnsemblGenomes-Gn:BSU04770" /db_xref="EnsemblGenomes-Tr:CAB12284" /db_xref="GOA:P96625" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12095" /db_xref="UniProtKB/Swiss-Prot:P96625" /translation="MEWHSKFSGPNTSPGFLLWQATQSWQRKVGKALAEFDLTHVQFV LLTSCKYMIAHGETVTQKKLASFSQTNIMMVSEVVRTLEKKGFIERSKNPQDKREVLL SLTEIGGEKVTAALPIVEKIDQAFFAAAMKKENFLSGLQELLKHE*" /label="ydcH CDS" gene 506773..507216 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /label="ydcH gene" downshifts 507191 /Source="Nicolas_upshifts" /id="D226" /incds=0 /nref=11 /ntot=147 /MaxReadThrough="2.17786" /MaxDrop="3.86856" /score="21.3746204" /energy="-6.8" /TU="NA" /idTUdmin="U376" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 507247..507248 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-35" promotor_-10 507264..507283 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-10" upshifts 507264 /Source="Nicolas_upshifts" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="upshifts" CDS 507310..509469 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755871, 12910271, 15383836, 16282592; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA helicase transcriptional accessory protein" /protein_id="NP_388359.2" /db_xref="EnsemblGenomes-Gn:BSU04780" /db_xref="EnsemblGenomes-Tr:CAB12285" /db_xref="GOA:O31489" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018974" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR023319" /db_xref="InterPro:IPR023323" /db_xref="InterPro:IPR032639" /db_xref="SubtiList:BG12096" /db_xref="UniProtKB/Swiss-Prot:O31489" /translation="METSALLKQQIAKEIGLSQKHVESVIRLLEDGNTVPFIARYRKE QTGSMDEVQIQTISERWQYIQNLNQRKEEVIRLIAEQDKLTDNLKRKIEQSVKLQEVE DLYRPYKQKRKTKATVAKSKGLEPLADYILTLPQDDHLAATADQYISEEKEVFTREEA IEGAKHIIAEQISDEPTFRKWIRQETFKRGTIKSAAGKSADTDEKNVYEMYYEYEEPI AKVVPHRVLAMNRGEKEDILKVAIEPPADHIKAYLEKQIIKNRSTSVREILQETIEDS YKRLIQPAIEREIRKELSEKADEQAIHIFSENLRKLLLQPPMKGKTVLGVDPAFRTGC KLAVSDETGKVLKIDVIYPHAPVNKTKEAHEKVKKILEQYQVEMVAIGNGTASRETEQ FIVNVLRDMPRKIYYVIVNEAGASVYSASELAREEFPDLKVEERSAVSIARRLQDPLA ELVKIDPKSVGVGQYQHDVSQKRLNESLRFVVETVVNQVGVNVNTASAALLQYVAGLS KSVAGNVVKKREEIGKFSNRKELKDIPRLGAKTYEQCIGFLRVQEGTEPLDRTGIHPE SYKETKALLKKLGLSTEHIGTAELKDKINQLALSETAKELGIGEITLKDICEQLTRPE RDPRDKVPKPLLKTDVLQLEDLKEGMELQGTVRNVVDFGAFVDIGVKQDGLVHISKLS NQFVKHPLDVVSVGDIVTVWVDGVDVQKGRVSLSMVK*" /label="tex CDS" gene 507310..509469 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /label="tex gene" misc_feature 509457..509476 /Source="Nicolas_upshift_promotors" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 509479..509695 /Source="Nicolas_S_feature" /locus_tag="new_527912_528128" /HighExp="Cold, Etha, LBGstat, dia5, LPhT, T4.0H, dia15, T3.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S167" upshifts 509479 /Source="Nicolas_upshifts" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="upshifts" CDS complement(509479..509592) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /function="16.3: Control" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:22463703, 26387458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22463703, 26387458; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor allowing degradation of SpoIVA by ClpXP" /protein_id="YP_009513946.1" /translation="MPNWLKKQMQKAFLEKDNYQIKLLNQCWYFYRKKHCS*" /label="cmpA CDS" gene complement(509479..509592) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /label="cmpA gene" promotor_-10 complement(509632..509651) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(509649) /Source="Nicolas_upshifts" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(509666..509674) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-35" CDS 509696..510148 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388360.1" /db_xref="EnsemblGenomes-Gn:BSU04790" /db_xref="EnsemblGenomes-Tr:CAB12286" /db_xref="GOA:P96628" /db_xref="InterPro:IPR006640" /db_xref="InterPro:IPR023524" /db_xref="InterPro:IPR035240" /db_xref="SubtiList:BG12098" /db_xref="UniProtKB/Swiss-Prot:P96628" /translation="MDNKELQKLTEDISETYFKKPFRHQALFNDRLKTTGGRYLLTSH NIELNRKYLIEHGREELIGIIKHELCHYHLHLEGKGYKHRDRDFRMLLQQVNAPRFCT PLKKKAENKKTYMYICTTCGQQYIKKRAMNPDRYRCGKCRGKIKRIFS*" /label="ydcK CDS" gene 509696..510148 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /label="ydcK gene" promotor_-35 510154..510160 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 510175..510194 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 510183..510270 /Source="Nicolas_S_feature" /locus_tag="new_528616_528703" /HighExp="C30, LBGstat, Cold, UNK1, GM 25, GM 120, GM 15, Heat, T-3.40H, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S168" upshifts 510183 /Source="Nicolas_upshifts" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(510215) /Source="Nicolas_upshifts" /id="D227" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="2.50342" /MaxDrop="3.97305" /score="8.78044068" /energy="-9.2" /TU="NA" /idTUdmin="U381" /TUdmin=704 /isTUend="FALSE" /label="downshifts" tRNA 510271..510345 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Asn tRNA" gene 510271..510345 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /label="trnS-Asn gene" tRNA 510350..510440 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Ser tRNA" gene 510350..510440 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /label="trnS-Ser gene" tRNA 510470..510541 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Glu tRNA" gene 510470..510541 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /label="trnS-Glu gene" tRNA 510553..510627 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Gln tRNA" gene 510553..510627 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /label="trnS-Gln gene" tRNA 510654..510729 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Lys tRNA" gene 510654..510729 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /label="trnS-Lys gene" tRNA 510741..510822 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu1 tRNA" gene 510741..510822 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /label="trnS-Leu1 gene" downshifts 510887 /Source="Nicolas_upshifts" /id="D228" /incds=0 /nref=3 /ntot=136 /MaxReadThrough="6.94232" /MaxDrop="3.5424" /score="34.987622" /energy="-13.7" /TU="U380" /idTUdmin="U378" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA 510903..>510988 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu (GAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu2 tRNA" gene 510903..>510988 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /modified_by="User" /label="trnS-Leu2 gene" SCAR 510988..510989 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="Delta6_2" S_feature complement(<510989..511295) /Source="Nicolas_S_feature" /locus_tag="new_549923_550239_c" /HighExp="Diami, dia15, dia5, HPh, Etha, H2O2, Cold, LPh, C90, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /modified_by="User" /label="S175" downshifts 511008 /Source="Nicolas_upshifts" /id="D238" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="0.144629999999999" /MaxDrop="3.58923" /score="4.45688042" /energy="-12.2" /TU="NA" /idTUdmin="U389" /TUdmin=84 /isTUend="FALSE" /label="downshifts" downshifts complement(511040) /Source="Nicolas_upshifts" /id="D239" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.31925" /MaxDrop="3.67068" /score="-2.66780619" /energy="-18.7" /TU="NA" /idTUdmin="U391" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(511296..512315) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /EC_number="1.14.14.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_388385.1" /db_xref="EnsemblGenomes-Gn:BSU05040" /db_xref="EnsemblGenomes-Tr:CAB12311" /db_xref="GOA:P96651" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12121" /db_xref="UniProtKB/Swiss-Prot:P96651" /translation="MKKFDISVLSVAPLRQGETMKQGIDSAVSLAKAVDNMGYKRIWF AEHHNHDAYASAATVSIVQHILANTKDIRVGSGGIMLPNHSPLIVAEQFGTLETLYPN RVDLALGRAPGTDQKTADVIRRSNHNGVFFFEREVNDILRFVGDKSVQGEVRAYPGIG THVPVFVLGSSTDSAEIAAKLGLPYAFGAQFSPHSMEEALSIYRENFQPSSYLQEPYV IACINVIAAESIDEASFISASHLQVYIDIYTNNLSKLIPPTENFLESLSQFELEILHS RLGYTIMGDRETIRRELIDFQQMYHADELIVLSNIYELSKEIQSYEILKQVVDELFKK RMEQL*" /label="yddN CDS" gene complement(511296..512315) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /label="yddN gene" promotor_-10 complement(511991..512010) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(512004) /Source="Nicolas_upshifts" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(512025..512032) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 512104..512108 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 512125..512144 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 512129 /Source="Nicolas_upshifts" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="upshifts" S_feature 512130..512574 /Source="Nicolas_S_feature" /locus_tag="new_551074_551518" /HighExp="dia15, dia5, H2O2, G180, G135, Paraq, HPh, LBGexp, Lbexp, G150" /AntisenseName="yddN" /AntisenseCor="0.70327972625798696" /AntisenseRegPval="-40.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S176" CDS 512575..512985 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388386.1" /db_xref="EnsemblGenomes-Gn:BSU05050" /db_xref="EnsemblGenomes-Tr:CAB12312" /db_xref="GOA:P96652" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12122" /db_xref="UniProtKB/Swiss-Prot:P96652" /translation="MIDEIDKKILDELSKNSRLTMKKLGEKVHLTAPATASRVVKLID NGIIKGCSIEVNQVKLGFSIHAFLNIYIEKIHHQPYLAFIETQDNYVINNYKVSGDGC YLLECKFPSNEVLDQFLNDLNKHANYKVSIVIGK*" /label="lrpA CDS" gene 512575..512985 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /label="lrpA gene" S_feature 512986..513055 /Source="Nicolas_S_feature" /locus_tag="new_551930_551999" /HighExp="dia15, dia5, H2O2, HPh, G180, G135, LBGtran, Paraq, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S177" downshifts 513012 /Source="Nicolas_upshifts" /id="D240" /incds=0 /nref=45 /ntot=194 /MaxReadThrough="2.99689" /MaxDrop="3.6808" /score="-1.98969146" /energy="-15.7" /TU="U392" /idTUdmin="U392" /TUdmin="-350" /isTUend="FALSE" /label="downshifts" CDS complement(513108..513557) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388387.1" /db_xref="EnsemblGenomes-Gn:BSU05060" /db_xref="EnsemblGenomes-Tr:CAB12313" /db_xref="GOA:P96653" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12123" /db_xref="UniProtKB/Swiss-Prot:P96653" /translation="MQIDSIDFQILQLLNKNARIQWKEIGEKIHMTGQAVGNRIKKME DNGIIKAYSIVVDELKMGFSFTAFVFFFMNAYMHDDLLKFIATRNEISEAHRVSGDAC YLLKVTVHSQEVLNHLLNDLLKYGNYQLYLSIKEVKKHYNTSLMSDE*" /label="lrpB CDS" gene complement(513108..513557) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /label="lrpB gene" CDS 513672..514214 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388388.1" /db_xref="EnsemblGenomes-Gn:BSU05070" /db_xref="EnsemblGenomes-Tr:CAB12314" /db_xref="GOA:P96654" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12124" /db_xref="UniProtKB/Swiss-Prot:P96654" /translation="MTTALLVIDIQNDYFPNGKMALTNPEKAAQNAAKLLSHFRNTGA PVFHVQHITEGNIAHFFHPNTEGVEIHESVRPLEKETVIVKHMPNSFFNTDLNGKLQE EGVKELVVCGMMSHMCIDATVRSAVEHGYVCQVVEDACATTTLQIEDKIVPAEHVHYA FMAALNGVYATVKTTEAFLK*" /label="yddQ CDS" gene 513672..514214 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /label="yddQ gene" promotor_-35 514687..514691 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 514708..514727 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 514717 /Source="Nicolas_upshifts" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="upshifts" CDS 514767..515531 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388389.1" /db_xref="EnsemblGenomes-Gn:BSU05080" /db_xref="EnsemblGenomes-Tr:CAB12315" /db_xref="GOA:P96655" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12125" /db_xref="UniProtKB/Swiss-Prot:P96655" /translation="MNITQIRNATIVVKYANKKFLIDPMLAEKGTYATFPETIRQDLF NPLVSLPTSIDNILDGVDAVIVTHLHLDHFDDVAKNVLPKNIKMFVQNEADAKEVKAS GFKNVEVLHQDTVFEGIQLVKTKGEHGRGEELLNLMGDVCGLVFKHPSEKVLYVAGDT VWYDAIEDEIHTHQPEIIVVNGGDNQRLDLGSLIMGKEDIYEVHKAAPHAKIISVHME AVNHWTLSREELKNFSKEKGFSSNILVPEDGESYTF*" /label="yddR CDS" gene 514767..515531 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /label="yddR gene" CDS 515725..517035 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388390.1" /db_xref="EnsemblGenomes-Gn:BSU05090" /db_xref="EnsemblGenomes-Tr:CAB12316" /db_xref="GOA:P96656" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12126" /db_xref="UniProtKB/Swiss-Prot:P96656" /translation="MVMTKKDTNISTQQPLWLQGYIDSPEKQNQLYKKTLKILIFSQI FGGAGLGAGITVGALLAQDMIGSENVAGIPTALFTFGSAVAALLIGASSQRFGRRAGL AGGFLIGGLGAIGVIIAALINSVALLFVSLLIYGAGMASNLQVRYAGTDLANEKQRAT AASMALVSTTLGAVVGPNLVNTMGEFADSIGVPNLAGPFIMSGAAFIIAGIILLIFLR PDPLFVSTAIANAEKKDDKVQIGGSLKNPAIDKKGIMVGAVIMILAQLIMTAIMTMTP VHMGHHGHGLSEVGLVIGLHIAAMYLPSPLTGLLVDKFGRTTMAIASGATLLAAGLVA AIAPADSLSLLILALVLLGVGWNFGLLTGTALIIDSTHPSLRAKTQGTFDVLLALSGA AGGALSGMVVAHSSYTILSISGAVLSLLLIPVVIWYFRRIQEKA*" /label="yddS CDS" gene 515725..517035 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /label="yddS gene" S_feature 517058..517617 /Source="Nicolas_S_feature" /locus_tag="new_556002_556561" /HighExp="S8, C30, Cold, BMM, C90, GM 25, MG 15, M/G, LPh, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S178" CDS 517618..517794 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved phage protein of unknown function" /protein_id="YP_003097682.1" /db_xref="EnsemblGenomes-Gn:BSU05099" /db_xref="EnsemblGenomes-Tr:CAX52553" /db_xref="GOA:Q9K3A9" /db_xref="UniProtKB/Swiss-Prot:Q9K3A9" /translation="MNNKKNIFDIVMYIIFGVLSLFLVAKTDYGTGVLVFVAILYLAV IAYKIKQVFSNSDS*" /label="ydzM CDS" gene 517618..517794 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /label="ydzM gene" CDS 517819..518505 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported phage protein" /protein_id="NP_388391.1" /db_xref="EnsemblGenomes-Gn:BSU05100" /db_xref="EnsemblGenomes-Tr:CAB12317" /db_xref="SubtiList:BG12127" /db_xref="UniProtKB/Swiss-Prot:P96657" /translation="MRKKRVITCVMAASLTLGSLLPAGYASAKEDSKTTPSYEELALH YKMKSEKISSNGKLVEIEYVSGNETHKVQMNGNNHTVKVDGIEQKGLNFEYDENVAKR TNYENNNLKSNEFTTQAAKPKKGYHYVGTLSGHTKAAKNALSVTMSLVGIVPGLGWGS KAATILFSYWAKEQIPDAYYKYDLYEKGAMTDSWYQYATVQFFEDKAHKKKMGKPWTS TPAKVDLPNS*" /label="yddT CDS" gene 517819..518505 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /label="yddT gene" promotor_-35 518847..518851 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-35" promotor_-10 518866..518885 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-10" upshifts 518874 /Source="Nicolas_upshifts" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="upshifts" Polymorphism join(518921,518923) /Source="geneious" /ID="SNP_BsDelta6_557866_557865" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)5 -> (T)6" /Codon_Change /Coverage=35 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value="3.2e-123" /Variant_Raw_Frequency=35 /comment="ydzN_translation_signal_variant" /modified_by="User" / /label="Polymorphism_Delta6" CDS 518930..519115 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097683.1" /db_xref="EnsemblGenomes-Gn:BSU05109" /db_xref="EnsemblGenomes-Tr:CAX52554" /db_xref="GOA:C0H3V7" /db_xref="UniProtKB/Swiss-Prot:C0H3V7" /translation="MRWSKWFNVFCIVALGSIYGYKLFTNQEVSTTRLIIASVIVLWN IVGLFSKESVKQAQQAN*" /label="ydzN CDS" gene 518930..519115 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /label="ydzN gene" downshifts 519114 /Source="Nicolas_upshifts" /id="D241" /incds=0 /nref=9 /ntot=125 /MaxReadThrough="3.39785" /MaxDrop="3.7067" /score="-6.31330934" /energy="-12.8" /TU="U394" /idTUdmin="U394" /TUdmin="-1068" /isTUend="FALSE" /label="downshifts" CDS 519465..520058 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /experiment="publication(s) with functional evidences, PMID:24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase III homolog, deglycase" /protein_id="NP_388392.1" /db_xref="EnsemblGenomes-Gn:BSU05110" /db_xref="EnsemblGenomes-Tr:CAB12318" /db_xref="GOA:P96658" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="PDB:3F5D" /db_xref="SubtiList:BG12128" /db_xref="UniProtKB/Swiss-Prot:P96658" /translation="MKKALFLILDQYADWEGVYLASALNQREDWSVHTVSLDPIVSSI GGFKTSVDYIIGLEPANFNLLVMIGGDSWSNDNKKLLHFVKTAFQKNIPIAAICGAVD FLAKNGLLNNHSHTGNFVYLWKDYKQYKPISSFVEKQAVRDKNLVTANGTAPIEFTNL ILEMIDFDTPENIEKMMYMNRYGFYHFCDKYGNPFVD*" /label="sufLC CDS" gene 519465..520058 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /label="sufLC gene" promotor_-35 520171..520178 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 520192..520211 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 520203..520320 /Source="Nicolas_S_feature" /locus_tag="new_559146_559263" /HighExp="B60, LoTm, T5.0H, T3.30H, M9-stat, BI, BC, C90, T3.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S179" upshifts 520203 /Source="Nicolas_upshifts" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(520238) /Source="Nicolas_upshifts" /id="D242" /incds=0 /nref=10 /ntot=93 /MaxReadThrough="1.86628" /MaxDrop="4.19111" /score="25.1917407" /energy="-12.9" /TU="NA" /idTUdmin="U396" /TUdmin=328 /isTUend="FALSE" /label="downshifts" CDS 520321..520521 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9379903, 9914312, 9920884, 10517332, 11591689, 12427936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379903, 9914312, 9920884, 10517332, 11591689, 12427936; Product type f : factor" /codon_start=1 /transl_table=11 /product="cold-shock protein" /protein_id="NP_388393.1" /db_xref="EnsemblGenomes-Gn:BSU05120" /db_xref="EnsemblGenomes-Tr:CAB12319" /db_xref="GOA:P39158" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11024" /db_xref="UniProtKB/Swiss-Prot:P39158" /translation="MEQGTVKWFNAEKGFGFIERENGDDVFVHFSAIQSDGFKSLDEG QKVSFDVEQGARGAQAANVQKA*" /label="cspC CDS" gene 520321..520521 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /label="cspC gene" S_feature complement(520419..521207) /Source="Nicolas_S_feature" /locus_tag="new_559362_560150_c" /HighExp="LoTm, B60, Cold, M9-stat, LPhT, B36, Sw, BC, S8, Salt" /AntisenseName="cspC" /AntisenseCor="0.39074308987975698" /AntisenseRegPval="-10.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S180" downshifts 520424 /Source="Nicolas_upshifts" /id="D243" /incds=1 /nref=19 /ntot=179 /MaxReadThrough="8.05368" /MaxDrop="3.4464" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 520525 /Source="Nicolas_upshifts" /id="D244" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="5.78621" /MaxDrop="5.83905" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=343 /isTUend="FALSE" /label="downshifts" misc_RNA complement(520589..520667) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /product="putative small conserved untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sncZ RNA" gene complement(520589..520667) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /label="sncZ gene" CDS complement(521208..521669) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26849219; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for repair and outgrowth of heat damaged spores" /protein_id="NP_388394.1" /db_xref="EnsemblGenomes-Gn:BSU05130" /db_xref="EnsemblGenomes-Tr:CAB12320" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG12129" /db_xref="UniProtKB/Swiss-Prot:P96659" /translation="MFQIGDNIVYPMHGAGIIEAIEEKEFLEEKQQYYVIRMSISNMT VMIPTSKILSSNIRPVTDILALKHIMHIFQHGESDRLLPWKQRYKINTDKIKTGEIQE GAEVVRDLMRMKKEKALNASEKKMLDNAYEFLISELEVIKGITEKQIKSFG*" /label="cdnL CDS" gene complement(521208..521669) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /label="cdnL gene" S_feature 521678..522223 /Source="Nicolas_S_feature" /locus_tag="new_560621_561166" /HighExp="Cold, G135, S8, G180, LoTm, S7, G150, HPh, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S181" upshifts complement(521721) /Source="Nicolas_upshifts" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(521728..521747) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(521763..521770) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 522190 /Source="Nicolas_upshifts" /id="D245" /incds=0 /nref=7 /ntot=141 /MaxReadThrough="0.289110000000001" /MaxDrop="4.3701" /score="26.1823933" /energy="-9.5" /TU="NA" /idTUdmin="U395" /TUdmin=864 /isTUend="FALSE" /label="downshifts" CDS complement(522237..522473) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388395.1" /db_xref="EnsemblGenomes-Gn:BSU05140" /db_xref="EnsemblGenomes-Tr:CAB12321" /db_xref="GOA:O31493" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12808" /db_xref="UniProtKB/Swiss-Prot:O31493" /translation="MYLGIVSTACAFLLWNHGLQLLNASSGGLFFFFQPLVGTLLGWI LLGEQIGGTFWIGSFLILSGVLLVIKEKEKEVKS*" /label="ydzE CDS" gene complement(522237..522473) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /label="ydzE gene" CDS complement(522571..523446) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388396.1" /db_xref="EnsemblGenomes-Gn:BSU05150" /db_xref="EnsemblGenomes-Tr:CAB12322" /db_xref="GOA:P96660" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG12130" /db_xref="UniProtKB/Swiss-Prot:P96660" /translation="MKNFVIDQNLKELTEHRTVELPVACYKTTINQNINGYIPLHWHD EIQFVLILKGIALFQINEEKIEVHEGDGLFINSGYLHMAEEKEGSDCTYICLNVSPHF VLSQELYSSYVQPYMFSTNLPYLFLAGNQQWAKNILDAVKKINQLIQQKTSLYEIDIT MQLTLMWKNLVVNGFQLEYDQSEMIKSHRMKQMLNWIHLHYVEKITLEDIAKAGQLSR SECCRYFKRMLNKTPLRYVMDYRIQKSLLLLQHPESNVTEVSYQVGFNSTSYFISKFQ QAMNMTPLSYKKMNS*" /label="ydeC CDS" gene complement(522571..523446) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /label="ydeC gene" CDS 523559..524518 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388397.1" /db_xref="EnsemblGenomes-Gn:BSU05160" /db_xref="EnsemblGenomes-Tr:CAB12323" /db_xref="GOA:P96661" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12131" /db_xref="UniProtKB/Swiss-Prot:P96661" /translation="MNTSNRRMGLFYVITGATCWGIGGTVAKKLFQEYQIDVNWLVTT RLLTAGMLLLMLQLFRKDRSQVIEVWKHKASAGQLLIFGLLGMLAVQYTYMASIQHGN AAVATLLQYLSPVIVIIYTLLRKQTVLTKQDIITVVLALVGCFFLLTNGSMSQLSVPA AAVVWGVLSGFAAAFYTLYAVGLLNKFDSLVVVGWAMIIGGFALGFIHPPWQLDFQRL TAEAYAYILFVILFGTMIAFWFFIKSLESLSPKETSLLGSLEPLSAVVTTVVWLKAPF GSFQWIGAICIIGITLILALHKEPSMESEKSILKIRNHANRDI*" /label="ydeD CDS" gene 523559..524518 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /label="ydeD gene" upshifts complement(523580) /Source="Nicolas_upshifts" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(523584..523603) /Source="Nicolas_upshift_promotors" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(524671..525543) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388398.1" /db_xref="EnsemblGenomes-Gn:BSU05170" /db_xref="EnsemblGenomes-Tr:CAB12324" /db_xref="GOA:P96662" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12132" /db_xref="UniProtKB/Swiss-Prot:P96662" /translation="MDLLKSMNRALKYIEENLTNDIDFQEAAKLAFCSEYHFKRMFSF LAGISLSEYIRRRRLTLAAFELKDSNVKVIDIAIKYGYNSPDSFARAFQNLHGINPSK ARFNGHSLKAYPRMTFQLTIKGGNEMNYRIEEKEAFRIVGIKKRVPIIFKGINPEIAS MWESLDEKAINKLKELSNVAPSGLISASTNFSEGRTEENGELDHYIGAATTKRCPDNF SRLEVPASTWAVFESIGPFPDTLQEVWGRIYSEWFPSSNYEQIEGPEILWNEHKDVTS PSFKSEIWIPITKK*" /label="ydeE CDS" gene complement(524671..525543) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /label="ydeE gene" promotor_-10 complement(525636..525641) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(525643..525644) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(525648) /Source="Nicolas_upshifts" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 525717..525723 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 525731 /Source="Nicolas_upshifts" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 525737..525756 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 525770..527158 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388399.2" /db_xref="EnsemblGenomes-Gn:BSU05180" /db_xref="EnsemblGenomes-Tr:CAB12325" /db_xref="GOA:P96663" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12133" /db_xref="UniProtKB/Swiss-Prot:P96663" /translation="MPINSFENYPMSWKPSIDKAEKPIYKALAGQLEQDILNGVLLPG TKLPPQRELADYLDLNVSTISKAFKVCELKGLLSATVGSGTFVSYDALSNAYLLEDTK PTHLIEMGAILPDHASYEPLLYQLKNMVHEEDYEKWFSYGRAGESLWQKDAAVKLIQR GGFETSVDHILFANGGQNAIAATLASLCKPGDRIGVDHHTYPGLKTVASLLSVQIVPI KSENDEMSPESLEYACKNENIKGLYLIPDYHNPTTSFMSVENRRMVADIVKKYNLFVI EDASYHLLNKNPLPALASFAPQQVIHIASLSKSLAPGLRLAYVAVPRQYKEPISKALY NLNITVSPLLAELTARTIVSNQFEVLIESHREQTIRRNQLVNRYVAGYTCLGVETGIF RWLLLPGKMSGAEFEELAARLGVQVYAAERFVVGNSCPERAVRVSVCAPKTLEELEQG LMILRRLLDDLT*" /label="ydeF CDS" gene 525770..527158 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /label="ydeF gene" downshifts 527134 /Source="Nicolas_upshifts" /id="D246" /incds=0 /nref=2 /ntot=61 /MaxReadThrough="0.91547" /MaxDrop="3.65963" /score="12.298375" /energy="-12.2" /TU="NA" /idTUdmin="U399" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS 527268..528560 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388400.1" /db_xref="EnsemblGenomes-Gn:BSU05190" /db_xref="EnsemblGenomes-Tr:CAB12326" /db_xref="GOA:P96664" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12134" /db_xref="UniProtKB/Swiss-Prot:P96664" /translation="MMLDKDSVKAIDVQTASLQSYISSPEKQKSLYKRTLFVVSISQI FGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGL SAGFMIGGLGAIGVIMAAIINSIFLLFISLLIYGAGTATNLQARYAGTDLANHKQRAT AVSITMVFTTFGAVAGPSLVNVMGDFALSIGVPSLAGPFILAAAAYMLAGVVLFIMLR PDPLVIARTIEAANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPV HMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAA FAPGESMILLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAA GGALSGMIVAGSSYLALSLIGGILSLLLIPVVVWSRGR*" /label="ydeG CDS" gene 527268..528560 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /label="ydeG gene" promotor_-35 528569..528575 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 528590..528609 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 528597 /Source="Nicolas_upshifts" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="upshifts" S_feature 528608..528718 /Source="Nicolas_S_feature" /locus_tag="new_567551_567661" /HighExp="LoTm, T4.0H, T3.30H, T2.30H, T3.0H, T2.0H, T1.30H, T5.0H, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S182" CDS 528719..529165 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388401.1" /db_xref="EnsemblGenomes-Gn:BSU05200" /db_xref="EnsemblGenomes-Tr:CAB12327" /db_xref="GOA:P96665" /db_xref="SubtiList:BG12135" /db_xref="UniProtKB/Swiss-Prot:P96665" /translation="MNHIKWLSDLKKAGLLALGKGVITLLKRFSLVIVTLMMSIVVVL AAAKESPGDHVISFDEPIILMISIGIVVFLLIPPLVMSFFGNLVVRIISGVYQCFIVF TFLGLIPIGFLIPNGFLTILVSIAGTLVSIASVAVTLCIGKNKKDI*" /label="ydeH CDS" gene 528719..529165 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /label="ydeH gene" downshifts 529194 /Source="Nicolas_upshifts" /id="D247" /incds=0 /nref=200 /ntot=251 /MaxReadThrough="2.56495" /MaxDrop="6.50538" /score="-1.7193297" /energy="-4.5" /TU="NA" /idTUdmin="U400" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 529245..529252 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 529267..529286 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 529268 /Source="Nicolas_upshifts" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="upshifts" CDS 529402..529995 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16390439" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388402.1" /db_xref="EnsemblGenomes-Gn:BSU05210" /db_xref="EnsemblGenomes-Tr:CAB12328" /db_xref="InterPro:IPR014922" /db_xref="InterPro:IPR016786" /db_xref="SubtiList:BG12136" /db_xref="UniProtKB/Swiss-Prot:P96666" /translation="MTNSRTNPKVDEFLSKAKKWKEEFEKLRTIILDCELTEDFKWMH PCYTYHNKNIVLIHGFKEYCALLFHKGVLLQDTDGILIQQTENVQAARQIRFTNVQEI NELENILKAYIHEAIEVEKAGLKVDVNKNIELNIPEELQNKFDEIPALKIAFEALTPG RQRAYTLYFSQAKQSKTRESRVEKYVQKILDGKGLKD*" /label="ydeI CDS" gene 529402..529995 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /label="ydeI gene" downshifts 530038 /Source="Nicolas_upshifts" /id="D248" /incds=0 /nref=2 /ntot=40 /MaxReadThrough="1.63432" /MaxDrop="2.96785" /score="2.93671425" /energy="-6.9" /TU="NA" /idTUdmin="U401" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(530114) /Source="Nicolas_upshifts" /id="D249" /incds=0 /nref=1 /ntot=64 /MaxReadThrough="2.19009" /MaxDrop="2.9369" /score="-1.28013562" /energy="-6.9" /TU="NA" /idTUdmin="U403" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 530127..530134 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 530148 /Source="Nicolas_upshifts" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 530149..530168 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(530347..531006) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388403.1" /db_xref="EnsemblGenomes-Gn:BSU05220" /db_xref="EnsemblGenomes-Tr:CAB12329" /db_xref="GOA:P96667" /db_xref="SubtiList:BG12137" /db_xref="UniProtKB/Swiss-Prot:P96667" /translation="MKKRRKICYCNTALLLMILLAGCTDSKDGEAQQPSNQASAVQTD EKHTEPEESTKIRKDEAEPITESEESATKAANDTSSAEEKSKEDNVLAAYSSEKIEYA RVWLQLGPNQEIDELNVRHIAAGEPINPNDDTSASYPENVTQLAGSRLVDGSVTYHGN GDGTIHVYNVPLRWDSADDIEKGVMREVTESIIKNRKTVYVDTGDDEKIKRLIDIMMI H*" /label="ydeJ CDS" gene complement(530347..531006) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /label="ydeJ gene" promotor_-10 complement(531055..531074) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(531062) /Source="Nicolas_upshifts" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(531086..531091) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(531428..532291) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388404.1" /db_xref="EnsemblGenomes-Gn:BSU05230" /db_xref="EnsemblGenomes-Tr:CAB12330" /db_xref="GOA:P96668" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12138" /db_xref="UniProtKB/Swiss-Prot:P96668" /translation="MNKTTNGWINGFIGVLIFSGSLPATRLAVSDFDPLFLTVCRAAI AGVLAGGLLLIFRQQHPAKRDLISLLVVAFGVVIGFPLLTALALQHVTSAHAIVFIGL LPLATAVFGVLRGGERPRPVFWIFSAAGSLLVAGFALIQGGGSSPLGDAYMLASIVVC GLGYAEGAKLSRRLGNWQVISWALVLSLPLMLPLSFFFTPDSWSAIGVPALLSLAYVS LFSMLIGFVFWYRGLAQGGIAAVGQLQLLQPFFGLLLASVILHEKVGWALVAVNIAVI MCVAAARRFAK*" /label="ydeK CDS" gene complement(531428..532291) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /label="ydeK gene" promotor_-35 532334..532340 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 532355..532374 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(532356..532375) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 532370 /Source="Nicolas_upshifts" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(532380) /Source="Nicolas_upshifts" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(532390..532397) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 532446..533837 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /function="16.3: Control" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388405.1" /db_xref="EnsemblGenomes-Gn:BSU05240" /db_xref="EnsemblGenomes-Tr:CAB12331" /db_xref="GOA:P96669" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12139" /db_xref="UniProtKB/Swiss-Prot:P96669" /translation="MDITPFLNRTLDIPLYQQLYRYFKENMHRGRIQKGMKLPSKRLL ANQLSISQTTVERAYEQLAAEGYIVSKPRSGWFADYHDSDFAYDRMPSTTPIQQEAEE NKQWIDFHYGNVDSSYFPFSAWRKSMVNSLDQYGHELYRPGHVLGEFELRTLIAEYLY QSRGVHCGPEQVIIGAGNPILLQILCQVFEPNISIGYEDPGYPRARKIFEANRMNIVP IPVDDEGICIQKIKEQQPNLVYVTPSHQFTLGTIMTINRRIQLLKWAAENQSFIIEDD YDGEFRYTGQPVPSLQGLDQHNRVIYMGTFSKSLLPSLRISYMILPSPLLKKGHEITS LYKQTVSCHSQLTLAEFIKNGEWQKHINRMRKLYRKKRAIVLEAVQRELGEHVRIRGE NSGLRILLDVYLPFGEKELIEKAKKHGVKIYPVSLSYQHHPPTKTVSLGFAGVSESDI REGIKKLKAAWKI*" /label="ydeL CDS" gene 532446..533837 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /label="ydeL gene" promotor_-35 533965..533972 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-35" promotor_-10 533983..534002 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-10" upshifts 533997 /Source="Nicolas_upshifts" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="upshifts" CDS 534031..534456 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1556068, 26349822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase" /protein_id="NP_388406.1" /db_xref="EnsemblGenomes-Gn:BSU05250" /db_xref="EnsemblGenomes-Tr:CAB12332" /db_xref="InterPro:IPR002539" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12140" /db_xref="UniProtKB/Swiss-Prot:P96670" /translation="MKLDEFTIGQVFKTKSLKVSKDDIMRFAGEFDPQYMHVDEEKAS KGRFNGIIASGIQTLAISFKLWIEEGFYGDDIIAGTEMNHMTFIKPVYPDDELFTIVE VLDKQPKRNELGILTVLLSTYNQKEVKVFEGELSVLIKR*" /label="ydeM CDS" gene 534031..534456 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /label="ydeM gene" S_feature 534457..535711 /Source="Nicolas_S_feature" /locus_tag="new_573400_574654" /HighExp="G135, H2O2, G150, HiOs, G180, Cold, Paraq, UNK1, MG 15, LBGexp" /AntisenseName="ydeN" /AntisenseCor="0.40423774227585801" /AntisenseRegPval="-11.3" /CDS_PredictionProba="0.127641" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S183" CDS complement(534509..535081) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15159570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alpha/beta hydrolase" /protein_id="NP_388407.1" /db_xref="EnsemblGenomes-Gn:BSU05260" /db_xref="EnsemblGenomes-Tr:CAB12333" /db_xref="GOA:P96671" /db_xref="InterPro:IPR010662" /db_xref="InterPro:IPR029058" /db_xref="PDB:1UXO" /db_xref="SubtiList:BG12141" /db_xref="UniProtKB/Swiss-Prot:P96671" /translation="MTKQVYIIHGYRASSTNHWFPWLKKRLLADGVQADILNMPNPLQ PRLEDWLDTLSLYQHTLHENTYLVAHSLGCPAILRFLEHLQLRKQLGGIILVSGFAKS LPTLQMLDEFTQGSFDHQKIIESAKHRAVIASKDDQIVPFSFSKDLAQQIDAALYEVQ HGGHFLEDEGFTSLPIVYDVLTSYFSKETR*" /label="ydeN CDS" gene complement(534509..535081) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /label="ydeN gene" downshifts complement(534514) /Source="Nicolas_upshifts" /id="D250" /incds=0 /nref=16 /ntot=160 /MaxReadThrough="1.96868" /MaxDrop="3.80195" /score="2.50673989" /energy="-11.3" /TU="NA" /idTUdmin="U407" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(535082..535162) /Source="Nicolas_S_feature" /locus_tag="new_574025_574105_c" /HighExp="dia15, dia5, Diami, Etha, LPhT, Lbtran, Heat, H2O2, Sw, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S184" CDS complement(535163..535492) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388408.1" /db_xref="EnsemblGenomes-Gn:BSU05270" /db_xref="EnsemblGenomes-Tr:CAB12334" /db_xref="GOA:O31494" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12809" /db_xref="UniProtKB/Swiss-Prot:O31494" /translation="MNSLCRSKQAPFEYTLSLIGGKWKMRILYELGCEKTMRYGELKR AMPFITHKMLSAQLKELQTDGLIHRSEVSHTPLKVEYSLSDRGRSLYPLIDEMCKWGM AQGGPHM*" /label="ydzF CDS" gene complement(535163..535492) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /label="ydzF gene" misc_feature complement(535509..535528) /Source="Nicolas_upshift_promotors" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(535526) /Source="Nicolas_upshifts" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="upshifts" misc_feature 535700..535719 /Source="Nicolas_upshift_promotors" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 535713 /Source="Nicolas_upshifts" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="upshifts" CDS 535747..536619 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388409.1" /db_xref="EnsemblGenomes-Gn:BSU05280" /db_xref="EnsemblGenomes-Tr:CAB12335" /db_xref="GOA:P96672" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12142" /db_xref="UniProtKB/Swiss-Prot:P96672" /translation="MNTPKKHKKFKAKMILQIIMVIIGGIIAAYGLETVLIPNSVSDG GVTGLSIVGSQLFNLPLGILIAVINIPFVWLGYKQIGKSFALLSIIGIVSLAAGTSFF HHTPAIIEGDTLLITVVGGIILGFGMGLALRNGGALDGIDMLAVLLSRKLPFGTSDLI LFLNLFVFIFVSTVFGLQGALLSVIAYYIASKVIHVVEEGLSGSKTFQIITTQPELMV ETIRDQLGRSATYKEAYGGFSHEKFKEITCVINRLEETKLKEIINDIDKTAFVTVYDV AEVKGSNFRNLNHH*" /label="ydeO CDS" gene 535747..536619 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /label="ydeO gene" downshifts 536506 /Source="Nicolas_upshifts" /id="D251" /incds=1 /nref=7 /ntot=181 /MaxReadThrough="3.84278" /MaxDrop="2.68681" /score="15.0132064" /energy="-12.2" /TU="U408" /idTUdmin="U408" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 536704 /Source="Nicolas_upshifts" /id="D252" /incds=0 /nref=54 /ntot=208 /MaxReadThrough="1.19842" /MaxDrop="3.77294" /score="15.0132064" /energy="-12.2" /TU="NA" /idTUdmin="U408" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(536769..537155) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388410.1" /db_xref="EnsemblGenomes-Gn:BSU05290" /db_xref="EnsemblGenomes-Tr:CAB12336" /db_xref="GOA:P96673" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12143" /db_xref="UniProtKB/Swiss-Prot:P96673" /translation="MRNRKLGIDYSSDDFEGCPVETTLDIIGGKWKGILLYHLIDGKK RFNEFRKLYPKITQRMLTLQLRELERDGVIHREVYKQVPPKVEYSLTEFGRTLEPVIL HMKDWGEKYKDRIDKLEAARKAEDKI*" /label="ydeP CDS" gene complement(536769..537155) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /label="ydeP gene" downshifts complement(536781) /Source="Nicolas_upshifts" /id="D253" /incds=0 /nref=29 /ntot=191 /MaxReadThrough="0.85093" /MaxDrop="4.4837" /score="-9.3516261" /energy="-12.9" /TU="NA" /idTUdmin="U409" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(537156..537220) /Source="Nicolas_S_feature" /locus_tag="new_576099_576163_c" /HighExp="Diami, dia5, Salt, dia15, Etha, Heat, G180, HiOs, LBGexp, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S185" promotor_-35 537208..537215 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(537209..537228) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(537222) /Source="Nicolas_upshifts" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 537229..537248 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 537232 /Source="Nicolas_upshifts" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(537243..537250) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 537266..537859 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /EC_number="1.6.99.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase involved in regulating potassium efflux" /protein_id="NP_388411.1" /db_xref="EnsemblGenomes-Gn:BSU05300" /db_xref="EnsemblGenomes-Tr:CAB12337" /db_xref="GOA:P96674" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12144" /db_xref="UniProtKB/Swiss-Prot:P96674" /translation="MDHMKTLVLVVHPNIESSRINKKWKEAVLSEPDVTVHDLYEKYR DQPIDVEFEQQQLLAHDRIVFQFPLYWYSSPPLLKQWFDEVFTFGWAHGPGGNKLKGK EWVTAMSIGSPEHSYQAGGYNLFSISELTKPFQASAHLVGMTYLPSFAEYRANTISDQ EIAESANRYVKHITNIELNPKVRLQRYLKQLESVDLT*" /label="ydeQ CDS" gene 537266..537859 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /label="ydeQ gene" CDS complement(538003..539190) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388412.1" /db_xref="EnsemblGenomes-Gn:BSU05310" /db_xref="EnsemblGenomes-Tr:CAB12338" /db_xref="GOA:P96675" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12145" /db_xref="UniProtKB/Swiss-Prot:P96675" /translation="MANGNKQAGQRISPSLTLLLATACGIIVANLYYAQPLVGLISKA IGLSPSGAGLIVTLTQIGYVAGLLFLVPLGDIIENKKLIVVSLLLSAAALTLTAFVKH GTLFLAAAFFVGLGSIAAQVLVPFASYLASDAARGRVVGNVMSGLLLGIMLSRPISSL VADIWGWNAIFALSAVVSVILAIVLSKVLPARKPTANTNYTALLGSMWKLLRTTPVLR RRAIYHAFVFGAFSLFWTTVPLLLSGPDFHFSQKAIALYALVGIAGAVTAPIGGRLAD RGLTRLATGIALGVVVVSLLLPLMIQSSSPVGITVLVAAAILLDMGVSANLVLSQRAI FSLAPEIRSRLNGLFMAIFFLGGAIGSSIGGWAYASGGWSTALWIGIAFPVIALLYFI TEK*" /label="ydeR CDS" gene complement(538003..539190) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /label="ydeR gene" promotor_-35 539326..539330 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 539344 /Source="Nicolas_upshifts" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 539345..539364 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 539394..539990 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15944459; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388413.1" /db_xref="EnsemblGenomes-Gn:BSU05320" /db_xref="EnsemblGenomes-Tr:CAB12339" /db_xref="GOA:P96676" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011075" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12146" /db_xref="UniProtKB/Swiss-Prot:P96676" /translation="MQSKRGRPRDEGTHKAILSAAYDLLLEKGFDAVTVDKIAERAKV SKATIYKWWSNKAAVIMDSFLSTATDRLPVPDTGSSVQDIVTHATNLARFLTSREGTV IKELIGAGQLDEKLAEEYRTRFFQPRRLQAKGLLEKGIQKGELRENLDIEVSIDLIYG PIFYRLLITGDEVNDSYVRDLVMNAFKGVQATSATESM*" /label="ydeS CDS" gene 539394..539990 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /label="ydeS gene" CDS 540104..540289 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097684.1" /db_xref="EnsemblGenomes-Gn:BSU05329" /db_xref="EnsemblGenomes-Tr:CAX52555" /db_xref="UniProtKB/Swiss-Prot:C0H3V9" /translation="MSKKKSFNREYITSYYYIPFHRLEQGFYTSMEYRKVGVFKQQGK IDGHYVGVMAMEKILAM*" /label="ydzO CDS" gene 540104..540289 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /label="ydzO gene" downshifts 540268 /Source="Nicolas_upshifts" /id="D254" /incds=0 /nref=5 /ntot=123 /MaxReadThrough="1.06987" /MaxDrop="2.89833" /score="-5.04743481" /energy="-6.3" /TU="NA" /idTUdmin="U411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 540401..540404 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 540411..540597 /Source="Nicolas_S_feature" /locus_tag="new_579354_579540" /HighExp="LBGstat, G180, LBGexp, G135, Paraq, G150, Oxctl, dia0, Diami, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S186" upshifts 540411 /Source="Nicolas_upshifts" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 540419..540438 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 540598..540933 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15948947, 16430705" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16430705; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (metals sensing ArsR-SmtB repressors family)" /protein_id="NP_388414.1" /db_xref="EnsemblGenomes-Gn:BSU05330" /db_xref="EnsemblGenomes-Tr:CAB12340" /db_xref="GOA:P96677" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12147" /db_xref="UniProtKB/Swiss-Prot:P96677" /translation="MTIDVAAMTRCLKTLSDQTRLIMMRLFLEQEYCVCQLVDMFEMS QPAISQHLRKLKNAGFVNEDRRGQWRYYSINGSCPEFDTLQLILHQIDQEDELLNHIK QKKTQACCQ*" /label="aseR CDS" gene 540598..540933 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /label="aseR gene" CDS 540946..542253 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12950922, 14970228, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite/antimonite/H+ antiporter" /protein_id="NP_388415.1" /db_xref="EnsemblGenomes-Gn:BSU05340" /db_xref="EnsemblGenomes-Tr:CAB12341" /db_xref="GOA:P96678" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12148" /db_xref="UniProtKB/Swiss-Prot:P96678" /translation="MTSMILAVFIFLLTLVLVIWQPKNLSIGWSACGGAVLALIAGVV NFHDVLTVTGIVWNATLAFVAIILISLILDNIGFFEWAALHMAKAAKGYGVRMFVYVS LLGAIVAALFANDGAALILTPIVLAMVRALHFNEKLVFPFIIASGFIADTTSLPFVVS NLVNIVSADYFHITFIDYASRMVVPYLFSLLASIIVLYLFFRKSIPKRYDLTEVKKPV EAIKDQNMFRLSWYILGLLLIGYFASEFFSIPVSVVAGSIAIIFLIAAQKSPAVHTKK VVKEAPWAIVFFSIGMYVVVYGVRNAGLTDVLSDVIQAAADQGLFAGTIGMGFIAAIL SSIMNNLPTVMIDALAIAGTDTHGMMREALIYANVIGSDLGPKITPIGSLATLLWLHV LSHKGMKISWGTYFKTGIILTIPTLLITLVGLYIWLLIIHSCF*" /label="arsF CDS" gene 540946..542253 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /label="arsF gene" CDS 542285..542389 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of ydzS" /translation="CTGNSCRSQMAEGWGRKYLGAKWNVYSAGIEAQG*" /label="ydzSn CDS" gene 542285..542389 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /pseudo /label="ydzSn gene" CDS 542398..542511 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of ydzS" /translation="AVKAMKEAGIDISNQTSEKFDDPAKAHGTEEVFPKGP*" /label="ydzSc CDS" gene 542398..542511 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /pseudo /label="ydzSc gene" promotor_-35 542697..542705 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 542716..542734 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 542733 /Source="Nicolas_upshifts" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 542751..543536 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388416.1" /db_xref="EnsemblGenomes-Gn:BSU05350" /db_xref="EnsemblGenomes-Tr:CAB12342" /db_xref="GOA:P96679" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027365" /db_xref="SubtiList:BG12149" /db_xref="UniProtKB/Swiss-Prot:P96679" /translation="MSVLQELTKKKYSSLKTMFDDKYCPTFVYSILDQTIPGAVYADD QTFPKSFFIGTESGIYFIAGDQGNRDFHDFIAGYYEEQVKSSKRFTLFSSSDTWDSVL KPILKDDLNQMRRAAFSYQPKSFKKTLQLPKGLVLKRIDEDIISHSTAFNSAYYEEYW NSVSQFASKGFGFAVLHGNHVVSECTSIFLGHNRAEMDIYTLEEYRGLGLAYCVANRF IAFCMENGIVPSWDCDICNNSSIALAAKLGFKTVTEYTIYYSG*" /label="ydfB CDS" gene 542751..543536 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /label="ydfB gene" downshifts 542798 /Source="Nicolas_upshifts" /id="D255" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="2.67554" /MaxDrop="5.08398" /score="39.1565399" /energy="-19.2" /TU="NA" /idTUdmin="U413" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 543546 /Source="Nicolas_upshifts" /id="D256" /incds=0 /nref=2 /ntot=90 /MaxReadThrough="0.161840000000001" /MaxDrop="3.51451" /score="-0.169292431" /energy="-13.6" /TU="NA" /idTUdmin="U413" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS complement(543593..544513) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid exporter" /protein_id="NP_388417.1" /db_xref="EnsemblGenomes-Gn:BSU05360" /db_xref="EnsemblGenomes-Tr:CAB12343" /db_xref="GOA:P96680" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12150" /db_xref="UniProtKB/Swiss-Prot:P96680" /translation="MRKKTVQIMISHSLMIGLWASAFPGIRAGLEGYTPEHLALFRLL IGSMALLLFAVLTQMRLPDLKDIPAIFLLGFLGFAFYHILLNIGEKTVSAGVASLLVT TAPIFSAMLSRLFYKEHFGFTKWLGSMISLLGVLLIAFGAGDFTYSMSGILVILLAAF SESIYFVFQARYIKKYGFIPFVTFTIWGGTIPMLVFLPGLGEEMMNASISATLSIVYL GLLPTVIPYFALAYVTSFVGASEATLSLYVTPALALIISWLWIGEIPTLLSLLGGVVT VGGVCFTYLKVNKMNKIFITHFSAKRVKKL*" /label="ydfC CDS" gene complement(543593..544513) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /label="ydfC gene" CDS 544646..546094 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388418.1" /db_xref="EnsemblGenomes-Gn:BSU05370" /db_xref="EnsemblGenomes-Tr:CAB12344" /db_xref="GOA:P96681" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12151" /db_xref="UniProtKB/Swiss-Prot:P96681" /translation="MSFPEEKKMKKLPKYRQIVHFIKEKIGNGEWPIGSKIPSQRTLA KDFQVNRSTVITALEELMADGLIEGTMGKGTVVINNTWTLMAKNSAPDWDQYVTSGIQ MPSRKIVQEINQSESNTDLIQLSKGELSAEIFPLAVMKEMMGKVSQHMEAFGYEEPKG YLPLREALSNYLKTIGINVSSSSILIVSGALQALQLISMGLLQRGSTVYLDQPSYLYS LHVFQSAGMKLTGLPMDNEGLLPENVHLTRGERGRAILYTNPCFHNPTGILMSKKRRE EILAVSENTQLPIIEDDIYRELWIDEIPPYPIKTIDKNGHVLYIGSLSKTLSPGLRIG WIVGPEPVIERLSDIKMQTDYGSSSLSQRVAAEWFTSGHYQQHVEKVRQQLKVRRELA LSALETHLKEVATWNIPKGGFFVWIKILPSISMKLLYTKALSKGILINLGSIYAQEKG NYIRLSYAYASLEDLQKGIYELGLMIKELASR*" /label="ydfD CDS" gene 544646..546094 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /label="ydfD gene" CDS complement(546212..546835) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavoprotein" /protein_id="NP_388419.1" /db_xref="EnsemblGenomes-Gn:BSU05380" /db_xref="EnsemblGenomes-Tr:CAB12345" /db_xref="GOA:P96682" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12152" /db_xref="UniProtKB/Swiss-Prot:P96682" /translation="MDIKKQDTRRFKEIKPKIMYYGTSTFLLTTLNEDGTTNISPMSS SWALGHYIILGVGLGGKAIDNLERHKECVINLPGPDLWENVERISSYSGKKSIPPLKK QIGFTYKKEKYEAAGLTPLQSKTVSPTRIKECPIQIEAEVKHIRLPEYESSFAIVETQ ALHFHAEESIILDENHINPSKWSPLIYNFRHYFGLGREVGKTFRSET*" /label="ydfE CDS" gene complement(546212..546835) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /label="ydfE gene" promotor_-10 complement(546859..546878) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 546867..546874 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(546878) /Source="Nicolas_upshifts" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 546889..546908 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 546891 /Source="Nicolas_upshifts" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(546893..546899) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 546925..547605 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388420.1" /db_xref="EnsemblGenomes-Gn:BSU05390" /db_xref="EnsemblGenomes-Tr:CAB12346" /db_xref="GOA:P96683" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12153" /db_xref="UniProtKB/Swiss-Prot:P96683" /translation="MNPNIAKISSLLSDPSRSSILLSLMDGRIHPAGELAYLANIKPQ TASFHLNKLLEAKLISVEKHGRHRYYRLADSDAANVIEQLLHIAPKAKVKSLKESKEK KDLHFARTCYDHLAGYVGVQMAHSLVEQGMLKKVDLNFEVTSEGALFFSKLGINEEQQ RNKRRAFARCCLDWSERQHHIAGALGNALLVRMLEEEWIVRMPKTRAIRITQSGKIAF EKHLNVKI*" /label="ydfF CDS" gene 546925..547605 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /label="ydfF gene" downshifts 547638 /Source="Nicolas_upshifts" /id="D257" /incds=0 /nref=113 /ntot=245 /MaxReadThrough="0.50202" /MaxDrop="4.24716" /score="-7.74889591" /energy="-4.5" /TU="U415" /idTUdmin="U415" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(547685..548128) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388421.1" /db_xref="EnsemblGenomes-Gn:BSU05400" /db_xref="EnsemblGenomes-Tr:CAB12347" /db_xref="GOA:P96684" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR004675" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG12154" /db_xref="UniProtKB/Swiss-Prot:P96684" /translation="MSQRVSYYEIAPEGMKIMMDMEKYTKQSSINRTTRELIKIRVSQ MNGCAFCIDMHTSDARKMGETEQRIYCLHAWNECDFYSPEEKAALELSEHITLIPSKR VPDELYHRVREHYDEEQYVDLVLIINQINSWNRISIAMGNRAASK*" /label="ydfG CDS" gene complement(547685..548128) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /label="ydfG gene" downshifts complement(547690) /Source="Nicolas_upshifts" /id="D258" /incds=0 /nref=10 /ntot=187 /MaxReadThrough="1.76648" /MaxDrop="3.73786" /score="0.225628164" /energy="-10.8" /TU="NA" /idTUdmin="U416" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(548151..548170) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(548175) /Source="Nicolas_upshifts" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(548184..548191) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(548214..548393) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097685.1" /db_xref="EnsemblGenomes-Gn:BSU05408" /db_xref="EnsemblGenomes-Tr:CAX52558" /db_xref="GOA:C0H3W0" /db_xref="UniProtKB/Swiss-Prot:C0H3W0" /translation="MNMYWFLGALLYFLIGTYIFIRVTRDSQSGSWILLALAAPLIIA GYPYFYSKKLLSKRR*" /label="ydzP CDS" gene complement(548214..548393) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /label="ydzP gene" CDS complement(548390..548533) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097686.1" /db_xref="EnsemblGenomes-Gn:BSU05409" /db_xref="EnsemblGenomes-Tr:CAX52559" /db_xref="UniProtKB/Swiss-Prot:C0H3W1" /translation="MKSIDLTILSLKRKGIRTEKVLKNQNPDRLSHMTDKNAQPKSKE KEE*" /label="ydzQ CDS" gene complement(548390..548533) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /label="ydzQ gene" promotor_-35 548484..548486 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 548502..548521 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 548518 /Source="Nicolas_upshifts" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 548801..550024 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YdfI]" /protein_id="NP_388422.1" /db_xref="EnsemblGenomes-Gn:BSU05410" /db_xref="EnsemblGenomes-Tr:CAB12348" /db_xref="GOA:P96685" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12155" /db_xref="UniProtKB/Swiss-Prot:P96685" /translation="MLIRNPFKDKYYSHDRRALNMLALRVPGLAFILMIYIASIVLQF VSGGWSILLLYAFTILIAIFALLHWHSYRWVKKRVILYFAVQGLITFALANLMTGFFI LVIIGLYAFLIGQIIGMADRRRTFLILYLLLLLVINSAYHLHKGEVLHFIVIAAPIMI VIITYAATFFAQVDEKIKAQLTLERLELAHQQVEQLTLQNERQRMARDLHDTLAQGLV SLNMQLDAIHVHLAKGNTERAKEIIQQSMKRVKSTIADARSAIDDLRSKSEEIGVLKE RITSLMDHFIESTGMACLLDYRLHQVLDVRTAENCYYIIGECMTNAAKHAEAKTIWIS IWDDEKGRLHLTVKDNGKGFDVEKGKKKRGHYGLLGIQERVRAINGQFNIKSTKLKGT QIEITVPIQGEMQDE*" /label="ydfH CDS" gene 548801..550024 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /label="ydfH gene" CDS 550017..550658 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YdfH]" /protein_id="NP_388423.1" /db_xref="EnsemblGenomes-Gn:BSU05420" /db_xref="EnsemblGenomes-Tr:CAB12349" /db_xref="GOA:P96686" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12156" /db_xref="UniProtKB/Swiss-Prot:P96686" /translation="MNKVLIVDDHLVVREGLKLLIETNDQYTIIGEAENGKVAVRLAD ELEPDIILMDLYMPEMSGLEAIKQIKEKHDTPIIILTTYNEDHLMIEGIELGAKGYLL KDTSSETLFHTMDAAIRGNVLLQPDILKRLQEIQFERMKKQRNETQLTEKEVIVLKAI AKGLKSKAIAFDLGVSERTVKSRLTSIYNKLGANSRTEAVTIAMQKGILTIDN*" /label="ydfI CDS" gene 550017..550658 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /label="ydfI gene" downshifts 550652 /Source="Nicolas_upshifts" /id="D259" /incds=0 /nref=5 /ntot=147 /MaxReadThrough="1.15378" /MaxDrop="2.65603" /score="8.33575703" /energy="-6.4" /TU="NA" /idTUdmin="U419" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(550685..550704) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(550706) /Source="Nicolas_upshifts" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(550718..550725) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 550766..550771 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 550774..552948 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative proton metabolite efflux transporter" /protein_id="NP_388424.1" /db_xref="EnsemblGenomes-Gn:BSU05430" /db_xref="EnsemblGenomes-Tr:CAB12350" /db_xref="GOA:P96687" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12157" /db_xref="UniProtKB/Swiss-Prot:P96687" /translation="MSKMLYTLGGWVARNRIKAICAWIVVLVAAIGLAVTLKPSFSED MSIPDTPSEKAMDVIQKEFPHGPDKGSIRVIFGAGDGEKLTGKPAKKAIEDTFKEISK DDSVDSIASPFVTGTIAKDGTVAYADIQYKSSADDIKDYSIKHLKDSLKMADDEGLQT ELSGDVPGAEMEIGGVSEIVGIILAFVVLAITFGSLLIAGLPILTALIGLGVSIGLVL IGTQVFDIASVSLSLAGMIGLAVGIDYALFIFTKHRQFLGEGIQKNESIARAVGTAGS AVVFAGLTVIVALCGLTVVNIPFMSAMGLTAGLSVLMAVLASITLVPAVLSIAGKRMI PKSNKKIEKQSTETNVWGRFVTKNPIMLSVCSILILIVISIPSMHLELGLPDAGMKAK DNPDRRAYDLLAEGFGEGFNGQLTIVADATNATENKAEAFADAVKEIKGLDHVASVTP AMPNKEGNFAIITVVPETGPNDVTTKDLVHDVRSLSDKNGVDLLVTGSTAVNIDISDR LNDAIPVFAVLIVGFAFVLLTIVFRSLLVPLVAVAGFMLTMTATLGICVFVLQDGNLI DFFKIPEKGPILAFLPILSIGILFGLAMDYQVFLVSRMREEYVKTNNPVQAIQAGLKH SGPVVTAAGLIMIFVFAGFIFAGEASIKANGLALSFGVLFDAFIVRMTLIPSVMKLMG NAAWYLPKWLDKIIPNVDIEGHQLTKEIQPEIDHEQKKQISV*" /label="ydfJ CDS" gene 550774..552948 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /label="ydfJ gene" upshifts 550784 /Source="Nicolas_upshifts" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 550786..550804 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(551850..551868) /Source="Nicolas_upshift_promotors" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(551850) /Source="Nicolas_upshifts" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(552952..553359) /Source="Nicolas_S_feature" /locus_tag="new_591895_592302_c" /HighExp="Paraq, H2O2, Oxctl, aero, LBGexp, dia15, GM 150, M/G, ferm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S187" promotor_-35 552969..552973 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 552983 /Source="Nicolas_upshifts" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 552986..553005 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(552997) /Source="Nicolas_upshifts" /id="D260" /incds=0 /nref=22 /ntot=134 /MaxReadThrough="-0.100210000000001" /MaxDrop="3.637" /score="4.29161871" /energy="-8.8" /TU="NA" /idTUdmin="U422" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(553360..554262) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7765103, 22248594, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7765103, 22248594, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase NP" /protein_id="NP_388425.1" /db_xref="EnsemblGenomes-Gn:BSU05440" /db_xref="EnsemblGenomes-Tr:CAB12351" /db_xref="GOA:P96688" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:2R11" /db_xref="SubtiList:BG11957" /db_xref="UniProtKB/Swiss-Prot:P96688" /translation="MSNHSSSIPELSDNGIRYYQTYNESLSLWPVRCKSFYISTRFGQ THVIASGPEDAPPLVLLHGALFSSTMWYPNIADWSSKYRTYAVDIIGDKNKSIPENVS GTRTDYANWLLDVFDNLGIEKSHMIGLSLGGLHTMNFLLRMPERVKSAAILSPAETFL PFHHDFYKYALGLTASNGVETFLNWMMNDQNVLHPIFVKQFKAGVMWQDGSRNPNPNA DGFPYVFTDEELRSARVPILLLLGEHEVIYDPHSALHRASSFVPDIEAEVIKNAGHVL SMEQPTYVNERVMRFFNAETGISR*" /label="cesA CDS" gene complement(553360..554262) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /label="cesA gene" S_feature complement(554263..554358) /Source="Nicolas_S_feature" /locus_tag="new_593206_593301_c" /HighExp="nit, ferm, aero, LoTm, M/G, GM 150, Diami, Paraq, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S188" promotor_-10 complement(554338..554357) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(554358) /Source="Nicolas_upshifts" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(554371..554378) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(554464..555153) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10200972, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388426.1" /db_xref="EnsemblGenomes-Gn:BSU05450" /db_xref="EnsemblGenomes-Tr:CAB12352" /db_xref="GOA:P96689" /db_xref="InterPro:IPR007563" /db_xref="SubtiList:BG12158" /db_xref="UniProtKB/Swiss-Prot:P96689" /translation="MFGTIFNTVMIIAGSIIGGIFKKGIKDEYQDILMQAMGFAAVAL GINAITQHLPDSKYPILFIVSLAIGGLLGQIINLELRFNKLVNKFSKSNLAEGLSTAV LLFCIGSLSILGPVEAALHGDYTYLLTNGMLDGITSIVLASTFGFGIAAAALVLFSWQ GSIYLFAQVMESAINTDLINEITIVGGILILSSGLSILGIKKFKTLNLLPSLLIPPVV IFVIHAFGLRF*" /label="ydfK CDS" gene complement(554464..555153) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /label="ydfK gene" CDS complement(555243..556055) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of efflux transporter" /protein_id="NP_388427.1" /db_xref="EnsemblGenomes-Gn:BSU05460" /db_xref="EnsemblGenomes-Tr:CAB12353" /db_xref="GOA:P96690" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12159" /db_xref="UniProtKB/Swiss-Prot:P96690" /translation="MKEFFSIGEVSKLFNVKISALRYYDEIGLLKPEYKDEQTNYRYY STQQFERLDTIKYLRALGLPINKLLDFYNSQNTNTLLHLLKSQQVEIDRKKKELERIE RKISRRITHIEDAVNMPLHQISKIKLPAMRVAYLQHEYVLGHDIEHSLAELRTHLNVN EDIFIGKIGLSISAANVKAKQFDKYSSIFMILEDENEKTSSEIIFPSREYLQIRFKGS HPEAEPYYKKLLAYMKEHHYEVAGDSIEITLIDYGITNNLDNYVTEILLPIK*" /label="ydfL CDS" gene complement(555243..556055) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /label="ydfL gene" promotor_-10 complement(556084..556103) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(556097) /Source="Nicolas_upshifts" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(556119..556126) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(556166..557059) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="primary Mn(II) efflux pump" /protein_id="NP_388428.2" /db_xref="EnsemblGenomes-Gn:BSU05470" /db_xref="EnsemblGenomes-Tr:CAB12354" /db_xref="GOA:C0SP78" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12160" /db_xref="UniProtKB/Swiss-Prot:C0SP78" /translation="MASEREQISRKVALIALIANLILMAGKVFFGLVGDSEAVFADGI HSAADVVASIAVLAVIGISNKPPDQDHPFGHGKAEVISEAIVGIILVIVSVYILIEAI LSFVKGPSVPQYSALFAALISYVAKEILYRYSIKQGKKWNSKAIIAIAYDHKGDIVAS LAAFIGVLLAIIGNSRGWSYLLYADAIASAIVAYLIFKISMELIRPSVDVLMEKSVDP ELIEEYKAVIFQCDQVKRIDRIRAREHGHYKLLDVRLSLDHDLTIKQGHDIAREIRNE IKRQFSDVEEVLIHVNPYFEE*" /label="mneP CDS" gene complement(556166..557059) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /label="mneP gene" downshifts complement(556186) /Source="Nicolas_upshifts" /id="D261" /incds=0 /nref=23 /ntot=121 /MaxReadThrough="1.07979" /MaxDrop="4.0938" /score="12.079524" /energy="-6.2" /TU="NA" /idTUdmin="U424" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(557060..557152) /Source="Nicolas_S_feature" /locus_tag="new_596003_596095_c" /HighExp="LPh, HPh, LPhT, UNK1, MG t5, MG 5, MG 15, BMM, GM 120, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S189" promotor_-10 complement(557133..557152) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(557150) /Source="Nicolas_upshifts" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(557168..557175) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 557341..557348 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 557363..557382 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 557369 /Source="Nicolas_upshifts" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 557535..558155 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388429.1" /db_xref="EnsemblGenomes-Gn:BSU05480" /db_xref="EnsemblGenomes-Tr:CAB12355" /db_xref="GOA:P96692" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="PDB:3BEM" /db_xref="SubtiList:BG12161" /db_xref="UniProtKB/Swiss-Prot:P96692" /translation="MAEFTHLVNERRSASNFLSGHPITKEDLNEMFELVALAPSAFNL QHTKYVTVLDQDVKEKLKQAANGQYKVVSSSAVLLVLGDKQAYQQAADIYEGLKVLGI LNKQEYDHMVQDTVSFYENRGEQFKRDEAIRNASLSAMMFMLSAKEKGWDTCPMIGFD AEAVKRILNIDDQFEVVMMITIGKEKTESRRPRGYRKPVNEFVEYM*" /label="ydfN CDS" gene 557535..558155 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /label="ydfN gene" promotor_-35 557879..557885 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 557890 /Source="Nicolas_upshifts" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 557899..557917 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 558171..559109 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /EC_number="1.13.11.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dioxygenase" /protein_id="NP_388430.1" /db_xref="EnsemblGenomes-Gn:BSU05490" /db_xref="EnsemblGenomes-Tr:CAB12356" /db_xref="GOA:P96693" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:3OAJ" /db_xref="SubtiList:BG12162" /db_xref="UniProtKB/Swiss-Prot:P96693" /translation="MAKKTMGIHHITAIVGHPQENTDFYAGVLGLRLVKQTVNFDDPG TYHLYFGNEGGKPGTIITFFPWAGARQGVIGDGQVGVTSYVVPKGAMAFWEKRLEKFN VPYTKIERFGEQYVEFDDPHGLHLEIVEREEGEANTWTFGEVTPDVAIKGFGGATLLS EQPDKTADLLENIMGLERVGKEGDFVRYRSAGDIGNVIDLKLTPIGRGQMGAGTVHHI AWRANDDEDQLDWQRYIASHGYGVTPVRDRNYFNAIYFREHGEILFEIATDPPGFAHD ETQETMGEKLMLPVQYEPHRTQIEQGLLPFEVRELD*" /label="ydfO CDS" gene 558171..559109 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /label="ydfO gene" promotor_-35 559097..559100 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 559115..559134 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 559122..559210 /Source="Nicolas_S_feature" /locus_tag="new_598065_598153" /HighExp="Etha, BT, S6, S7, S8, G/S, GM 10, Gly, GM 15, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB, SigA" /TUshortPSig="0.658, 0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S190" upshifts 559122 /Source="Nicolas_upshifts" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 559211..559600 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15306018, 15849754, 16850406, 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound oxidoreductase" /protein_id="NP_388431.1" /db_xref="EnsemblGenomes-Gn:BSU05500" /db_xref="EnsemblGenomes-Tr:CAB12357" /db_xref="GOA:P96694" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12163" /db_xref="UniProtKB/Swiss-Prot:P96694" /translation="MEDAGLLLIRIMIGVVFLFYGTQKLFGWFGGYGIKGTGQWFESI GVKPGNVAAALSGLGELVSGILFILGVFLPLGAAIITIIMLGAIVKVHGAKGFANGAG GFEYNLVLIAVSIGVALIGSGAYALHF*" /label="ydfP CDS" gene 559211..559600 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /label="ydfP gene" downshifts 559591 /Source="Nicolas_upshifts" /id="D262" /incds=0 /nref=3 /ntot=91 /MaxReadThrough="1.0642" /MaxDrop="3.85597" /score="-8.69038499" /energy="-9.3" /TU="NA" /idTUdmin="U427" /TUdmin=29 /isTUend="FALSE" /label="downshifts" misc_feature 559714..559733 /Source="Nicolas_upshift_promotors" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 559716..559785 /Source="Nicolas_S_feature" /locus_tag="new_598659_598728" /HighExp="Diami, dia5, H2O2, dia15, Etha, S8, Paraq, Salt, LPhT, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S191" upshifts 559716 /Source="Nicolas_upshifts" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 559786..560124 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388432.1" /db_xref="EnsemblGenomes-Gn:BSU05510" /db_xref="EnsemblGenomes-Tr:CAB12358" /db_xref="GOA:P96695" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12164" /db_xref="UniProtKB/Swiss-Prot:P96695" /translation="MKEMTGLHSLVSIENFIKQHKFSFIYISRPGCTVCHAVLPQLRI VLDQFPNIKLGHINADDVAEVAGRFSVFTVPVLLLFIDGTEFLREARFVHFEQLEQKL KRVYRLYEGE*" /label="ydfQ CDS" gene 559786..560124 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /label="ydfQ gene" downshifts 560112 /Source="Nicolas_upshifts" /id="D263" /incds=0 /nref=9 /ntot=28 /MaxReadThrough="1.76745" /MaxDrop="4.78737" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(560164..560400) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="NP_388433.1" /db_xref="EnsemblGenomes-Gn:BSU05520" /db_xref="EnsemblGenomes-Tr:CAB12359" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12810" /db_xref="UniProtKB/Swiss-Prot:O31496" /translation="MRSQINISNLTINGMTQNANTDIGQNLQNSHTANSKNYGVNFTL GDYSPSHSIIISASCDNDTSDQGQVDNPSSPSEE*" /label="ydzH CDS" gene complement(560164..560400) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /label="ydzH gene" downshifts complement(560188) /Source="Nicolas_upshifts" /id="D264" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.87679" /MaxDrop="2.5881" /score="9.38580075" /energy="-6" /TU="NA" /idTUdmin="U430" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 560212..560218 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 560233..560244 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 560244 /Source="Nicolas_upshifts" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(560401..560562) /Source="Nicolas_S_feature" /locus_tag="new_599344_599505_c" /HighExp="BT, B36, S8, S7, G135, S5, S6, G180, Pyr, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S192" S_feature complement(560566..560931) /Source="Nicolas_S_feature" /locus_tag="new_599509_599874_c" /HighExp="BT, B36, S8, S7, S6, G/S, S5, Pyr, B60, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigGF, SigK" /TUshortPSig="0.994, 0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S193" downshifts complement(560606) /Source="Nicolas_upshifts" /id="D265" /incds=0 /nref=26 /ntot=52 /MaxReadThrough="2.64253" /MaxDrop="4.6761" /score="8.29803249" /energy="-12.4" /TU="NA" /idTUdmin="U430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(560932..561162) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="YP_003097687.1" /db_xref="EnsemblGenomes-Gn:BSU05529" /db_xref="EnsemblGenomes-Tr:CAX52560" /db_xref="InterPro:IPR019618" /db_xref="UniProtKB/Swiss-Prot:C0H3W2" /translation="MMKFPVYIHSISGNSVFNNGFAVSISPFSVSKTTEGSGGSNTGL VFESNALSQTSSANQAQNVTYAIQELLSKLLA*" /label="ydzR CDS" gene complement(560932..561162) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /label="ydzR gene" downshifts 561146 /Source="Nicolas_upshifts" /id="D266" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.08051" /MaxDrop="3.36374" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(561183..561202) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(561200) /Source="Nicolas_upshifts" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(561202..561285) /Source="Nicolas_S_feature" /locus_tag="new_600145_600228_c" /HighExp="S8, S5, S7, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK" /TUshortPSig="0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S194" promotor_-35 complement(561216..561225) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(561286..561963) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_388434.1" /db_xref="EnsemblGenomes-Gn:BSU05530" /db_xref="EnsemblGenomes-Tr:CAB12360" /db_xref="GOA:P96696" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12165" /db_xref="UniProtKB/Swiss-Prot:P96696" /translation="MNRLPFGYIKLRLAGRKANPMTNLIHHWSGGSMNFTWESLVLIV AGVILLRISGRKSIAQMTSTQTVVMISIGTIIVQPIIEYSLFKTLIAAAIFTSTLIVM EWIQMKSNTIEKMLTGKAKIVIENGQLHIENLKKMRLTADQLEMQLRLHGVTAIQDVK IATLEANGQLGIELTDDAKPLTVRDLKKLIHPDFINKDGQAQSGNQNIFDEVGKKNKK NVPKKLH*" /label="ydfR CDS" gene complement(561286..561963) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /label="ydfR gene" promotor_-10 complement(561934..561945) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(561948) /Source="Nicolas_upshifts" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(561960..561966) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(561964..562797) /Source="Nicolas_S_feature" /locus_tag="new_600907_601740_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, nit, B60" /AntisenseName="ydfS" /AntisenseCor="0.65823831974361602" /AntisenseRegPval="-34.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S195" promotor_-35 561979..561984 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 561999..562010 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 562004 /Source="Nicolas_upshifts" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="upshifts" CDS 562076..562783 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388435.1" /db_xref="EnsemblGenomes-Gn:BSU05540" /db_xref="EnsemblGenomes-Tr:CAB12361" /db_xref="GOA:P96697" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12166" /db_xref="UniProtKB/Swiss-Prot:P96697" /translation="MIELEVVIRTVASFGLLLIAERILGKQTISQMTIFDFIAAITLG AIAAGLAYNTSIKPHNMAISFSIFVLTIFLISFLSIKNRKLRKFFAGDPTVLIQNGKI LESNMRKMRYTLDYLNQQLREKEIFNIEEVLFAILETNGQLTVLRKPQFRHVTKQDLM IAVNQEQRLPIELIMDGEIIENNLKQNRLTESWLLEELRKRDIKVKETVYAVLLGNGD IYVDQYKDHISVPMDKE*" /label="ydfS CDS" gene 562076..562783 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /label="ydfS gene" CDS complement(562798..563229) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11150673; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_388436.1" /db_xref="EnsemblGenomes-Gn:BSU05550" /db_xref="EnsemblGenomes-Tr:CAB12362" /db_xref="GOA:P96698" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG12167" /db_xref="UniProtKB/Swiss-Prot:P96698" /translation="MDFEKIRKWLEITNEYKQSDFWTNVLKYKAPEHFFDSEASTFVY DFYQDEEYNFIIVEMPGVYEEELTIRLLSKTQLLIKGTITPVFPAEMEVLRERYYGEI ERIIQLPEAAETHLLQIQLLNGLLHISYPRQVETVAFNKGL*" /label="cotP CDS" gene complement(562798..563229) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /label="cotP gene" CDS complement(563242..563484) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388437.1" /db_xref="EnsemblGenomes-Gn:BSU05560" /db_xref="EnsemblGenomes-Tr:CAB12363" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12168" /db_xref="UniProtKB/Swiss-Prot:P96699" /translation="MPYQINIANIKINGVTQNGNIDVGPTVHNSHTANSKYFGANFSL GDLSPTSSLLNTGNIDSDVSDQDQIGNPSAPISNQI*" /label="ydgA CDS" gene complement(563242..563484) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /label="ydgA gene" CDS complement(563498..563770) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388438.1" /db_xref="EnsemblGenomes-Gn:BSU05570" /db_xref="EnsemblGenomes-Tr:CAB12364" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12169" /db_xref="UniProtKB/Swiss-Prot:P96700" /translation="MPSTVINLYYLKINSISGNGSITIGEAAYNSPTNNQKSQGTNSS FGDTSPTESVMENFLNDPDVNDQTSIGNSDTSNVNAPPIAPPPILD*" /label="ydgB CDS" gene complement(563498..563770) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /label="ydgB gene" promotor_-10 complement(563792..563811) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(563796) /Source="Nicolas_upshifts" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(563825..563834) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 563989..563996 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 564012..564031 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 564020 /Source="Nicolas_upshifts" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="upshifts" CDS 564069..564656 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388439.1" /db_xref="EnsemblGenomes-Gn:BSU05580" /db_xref="EnsemblGenomes-Tr:CAB12365" /db_xref="GOA:P96701" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12170" /db_xref="UniProtKB/Swiss-Prot:P96701" /translation="MKSKGVESRKRLLKAAANEFSVRGFHDAKVSEIVKKAGFTQPSF YLYFQSKEAIFAELITDFHSRVRKLTESLLLENGLNTEDVSKRVLLAVETVFQFLDED KDLTKIGFFLNPEAKQMKKDLAMVLKENLEAEQRLGYFHSELDMETVAECLVGMIEHL TESFLLTGIKDPASLAAEVVNLLIYGMLPKGNDVR*" /label="ydgC CDS" gene 564069..564656 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /label="ydgC gene" CDS 564653..564997 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388440.1" /db_xref="EnsemblGenomes-Gn:BSU05590" /db_xref="EnsemblGenomes-Tr:CAB12366" /db_xref="GOA:P96702" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12171" /db_xref="UniProtKB/Swiss-Prot:P96702" /translation="MISIMMKVSLAVFMLAGGIIKVSRVPFQVEHWRHYQYPLWFLTV TGILEIAGALAMTAGIWNRYAAIGAGVLFVVLMAGAIHAHMFRARQSVIMAIQAMICL IVSIMIIMGSYT*" /label="ydgD CDS" gene 564653..564997 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /label="ydgD gene" S_feature 564998..565159 /Source="Nicolas_S_feature" /locus_tag="new_603941_604102" /HighExp="Salt, Diami, dia15, dia5, aero, H2O2, SMMPr, Etha, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S196" CDS 565160..565633 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388441.1" /db_xref="EnsemblGenomes-Gn:BSU05600" /db_xref="EnsemblGenomes-Tr:CAB12367" /db_xref="GOA:P96703" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12172" /db_xref="UniProtKB/Swiss-Prot:P96703" /translation="MAFTLEDMTEEEFEAFRGMSVQNFAKQNITSGTWTEKEAFEKSE QAYENMIPNGRDSSNHYFWNITNDQGERMGWLWLYADPLHPQKEAFIYSFGLYEAFRG KGLAQLALQTLDERARELGAERLALHVFAHNETAVYLYQKMGYAMTNIRMRKQLC*" /label="ydgE CDS" gene 565160..565633 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /label="ydgE gene" S_feature 565634..566326 /Source="Nicolas_S_feature" /locus_tag="new_604577_605269" /HighExp="Salt, H2O2, dia15, aero, T-2.40H, Diami, T-3.40H, T-1.40H, T-4.40H, T-0.40H" /AntisenseName="vmlR" /AntisenseCor="-7.1224465259194999E-2" /AntisenseRegPval="-0.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S197" downshifts complement(565776) /Source="Nicolas_upshifts" /id="D267" /incds=0 /nref=4 /ntot=88 /MaxReadThrough="0.39199" /MaxDrop="3.39645" /score="18.2783449" /energy="-8.8" /TU="NA" /idTUdmin="U436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(565793..567436) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16109936, 22226636, 24687494, 25891423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16109936, 22226636, 24687494, 25891423; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding cassette efflux transporter" /protein_id="NP_388442.1" /db_xref="EnsemblGenomes-Gn:BSU05610" /db_xref="EnsemblGenomes-Tr:CAB12368" /db_xref="GOA:P39115" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG10767" /db_xref="UniProtKB/Swiss-Prot:P39115" /translation="MKEIVTLTNVSYEVKDQTVFKHVNASVQQGDIIGIIGKNGAGKS TLLHLIHNDLAPAQGQILRKDIKLALVEQETAAYSFADQTPAEKKLLEKWHVPLRDFH QLSGGEKLKARLAKGLSEDADLLLLDEPTNHLDEKSLQFLIQQLKHYNGTVILVSHDR YFLDEAATKIWSLEDQTLIEFKGNYSGYMKFREKKRLTQQREYEKQQKMVERIEAQMN GLASWSEKAHAQSTKKEGFKEYHRVKAKRTDAQIKSKQKRLEKELEKAKAEPVTPEYT VRFSIDTTHKTGKRFLEVQNVTKAFGERTLFKNANFTIQHGEKVAIIGPNGSGKTTLL NIILGQETAEGSVWVSPSANIGYLTQEVFDLPLEQTPEELFENETFKARGHVQNLMRH LGFTAAQWTEPIKHMSMGERVKIKLMAYILEEKDVLILDEPTNHLDLPSREQLEETLS QYSGTLLAVSHDRYFLEKTTNSKLVISNNGIEKQLNDVPSERNEREELRLKLETERQE VLGKLSFMTPNDKGYKELDQAFNELTKRIKELDHQDKKD*" /label="vmlR CDS" gene complement(565793..567436) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /label="vmlR gene" S_feature complement(567471..567668) /Source="Nicolas_S_feature" /locus_tag="new_606414_606611_c" /HighExp="BC, Sw, B60, B36, LoTm, S7, HiOs, S4, BI, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S198" promotor_-35 567485..567487 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 567504..567522 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 567508 /Source="Nicolas_upshifts" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(567514) /Source="Nicolas_upshifts" /id="D268" /incds=0 /nref=210 /ntot=265 /MaxReadThrough="3.59768" /MaxDrop="6.27457" /score="29.5863709" /energy="-11.8" /TU="U436" /idTUdmin="U437" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 567634 /Source="Nicolas_upshifts" /id="D269" /incds=0 /nref=35 /ntot=150 /MaxReadThrough="1.71902" /MaxDrop="4.95368" /score="-7.23582918" /energy="-13.3" /TU="NA" /idTUdmin="U435" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(567660..567679) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(567672) /Source="Nicolas_upshifts" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(567692..567699) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(567755) /Source="Nicolas_upshifts" /id="D270" /incds=0 /nref=92 /ntot=203 /MaxReadThrough="2.22553" /MaxDrop="5.71399" /score="18.9878298" /energy="-13.3" /TU="NA" /idTUdmin="U437" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(567756..569132) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16109936, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388443.1" /db_xref="EnsemblGenomes-Gn:BSU05620" /db_xref="EnsemblGenomes-Tr:CAB12369" /db_xref="GOA:P96704" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12173" /db_xref="UniProtKB/Swiss-Prot:P96704" /translation="MTDDMTKDNINQQTLQRGLKNRHIQLIAIGGAIGTGLFLGSGKS IHFAGPSILFAYMITGIICFLIMRSLGELLLSNLNYHSFVDFVQDYLGDMAAFITGWT YWFCWISIAMADLTAVGLYTQYWLPGVPQWVPGLIALIILLIMNLATVKLFGELEFWF ALIKVIAILALIVIGLVMIFKGFSTSSGVSSFTNLWSHGGLFPNGMHGFILSFQMVVF AFVGIELVGLTAGETENPEKVIPKAINNIPVRVLLFYIGALLVIMSIYPWDIINPSES PFVQVFVAVGIVGAASIINFVVLTSAASACNSAVFSTSRMVYSLAKDHNAPESMAKLT QRKVPRNALFFSAIVILIGVTLNYIMPEGVFTLITSISTVCFIYIWGITVICHMKYRK TRPELAKTNKFKLPLYPFTNYLILAFLAFVLVVLALAQDTRVSLFVTPVWFILLIVIY KVRKAKHQ*" /label="ydgF CDS" gene complement(567756..569132) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /label="ydgF gene" misc_feature complement(569182..569201) /Source="Nicolas_upshift_promotors" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(569197) /Source="Nicolas_upshifts" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="upshifts" Polymorphism join(569271,569273) /Source="geneious" /ID="SNP_BsDelta6_608215_608214" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)5 -> (A)6" /Codon_Change /Coverage=41 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="8.2e-115" /Variant_Raw_Frequency=39 /comment="dinB_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" terminator 569272..569305 /created_by="User" /comment="dinB_terminator_improvement" /modified_by="User" /label="Delta6_dinB_Terminator" CDS complement(569304..569822) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1847907, 3110138, 12644484, 16267290, 22059487; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nuclease inhibitor" /protein_id="NP_388444.1" /db_xref="EnsemblGenomes-Gn:BSU05630" /db_xref="EnsemblGenomes-Tr:CAB12370" /db_xref="GOA:Q02886" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG10539" /db_xref="UniProtKB/Swiss-Prot:Q02886" /translation="MSDFAFKLYEYNVWANQQIFNRLKELPKEIYHQEIQSVFPSISH VLSHVYLSDLGWIEVFSGKTLSDALALAEQLKEQTEAKEIEEMEDLFLRLSERYILFL QQKEQLNKPLQIQNPSSGIMKTTVSELLPHVVNHGTYHRGNITAMLRQAGYASAPTDY GLYLFMTKTEKA*" /label="dinB CDS" gene complement(569304..569822) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /label="dinB gene" downshifts complement(569318) /Source="Nicolas_upshifts" /id="D271" /incds=0 /nref=35 /ntot=176 /MaxReadThrough="2.77148" /MaxDrop="6.32316" /score="16.2748201" /energy="-15" /TU="NA" /idTUdmin="U438" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(569848..569867) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(569867) /Source="Nicolas_upshifts" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(569883..569886) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 569904..569911 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 569926..569945 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 569944 /Source="Nicolas_upshifts" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="upshifts" CDS complement(569956..570357) /gene="ydhUc" /locus_tag="PG10_BSU_05890_3'_ext" /locus_tag="BSU_05890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; C-terminal part of YhdU" /db_xref="SubtiList:BG12198" /modified_by="User" /translation="FFQSSNFRGKQKQYRDLLRGIFLEEIAHVELVQNTINALLDESG GEGVGSQGTDQAPLDEAVKHANPHHYIIGAQSSLPVDAGGNPWNGSWVYNHGNLITDL LDNLLLESTGVLQKTRIYEMSSNQTHYSLPR*" /label="PG10_BSU_05890_3'_ext" CDS complement(569956..570084) /locus_tag="PG10_rand_002" /created_by="User" /transl_table=11 /pseudo /translation="MYNHGNLITDLLDNLLLESTGVLQKTRIYEMSSNQTHYSLPR*" /label="PG10_rand_002" gene complement(569956..570357) /gene="ydhUc" /locus_tag="PG10_BSU_05890_3'_ext" /old_locus_tag="BSU_05890" /pseudo /modified_by="User" /label="PG10_BSU_05890_3'_ext" gene complement(569956..570084) /locus_tag="PG10_rand_002" /created_by="User" /label="PG10_rand_002" CDS 569974..570066 /locus_tag="PG10_rand_001" /created_by="User" /transl_table=11 /pseudo /translation="MRLIRAHFINSCFLQHTCRLKKQVIQQVSN*" /label="PG10_rand_001" gene 569974..570066 /locus_tag="PG10_rand_001" /created_by="User" /modified_by="User" /label="PG10_rand_001" SCAR 569976..569977 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs22" CDS complement(570288..570482) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; N-terminal part of YhdU" /translation="MYYYKEELINIIKPDKPDPAAAKVLQEILGGHYGEMRTMMQFFS KALISEESRNSTAICFAAFF*" /label="ydhUn CDS" gene complement(570288..570482) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /pseudo /label="ydhUn gene" promotor_-10 complement(570515..570526) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(570523) /Source="Nicolas_upshifts" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(570540..570546) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 570601..570608 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 570622..570641 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box 570624..570724 /Source="Nicolas_upshift_promotors" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 570626 /Source="Nicolas_upshifts" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(570672) /Source="Nicolas_upshifts" /id="D286" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="2.24619" /MaxDrop="4.20389" /score="11.9939391" /energy="-9" /TU="NA" /idTUdmin="U456" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" upshifts 570684 /Source="Nicolas_upshifts" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 570692..570699 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 570713..570732 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 570728..570815 /Source="Nicolas_S_feature" /locus_tag="new_635022_635109" /HighExp="LBGstat, C30, Cold, Heat, Oxctl, T-1.10H, T-0.40H, T-1.40H, UNK1, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.96, 0.0919, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S204" upshifts 570728 /Source="Nicolas_upshifts" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" tRNA 570816..570892 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Arg tRNA" gene 570816..570892 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /label="trnE-Arg gene" tRNA 570906..570979 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(UCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Gly tRNA" gene 570906..570979 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /label="trnE-Gly gene" rRNA 571139..572693 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-16S rRNA" gene 571139..572693 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /label="rrnE-16S gene" rRNA 572861..575788 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-23S rRNA" gene 572861..575788 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /label="rrnE-23S gene" rRNA 575844..575960 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-5S rRNA" gene 575844..575960 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /label="rrnE-5S gene" tRNA 575974..576050 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Met tRNA" gene 575974..576050 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /label="trnE-Met gene" tRNA 576111..576187 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Asp tRNA" gene 576111..576187 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /label="trnE-Asp gene" downshifts 576184 /Source="Nicolas_upshifts" /id="D287" /incds=0 /nref=38 /ntot=211 /MaxReadThrough="6.00554" /MaxDrop="5.14761" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U460" /TUdmin="-3784" /isTUend="FALSE" /label="downshifts" promotor_-35 576288..576292 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 576308..576327 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 576312 /Source="Nicolas_upshifts" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="upshifts" CDS 576368..577345 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /EC_number="2.7.4.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-monophosphate kinase" /protein_id="NP_388471.1" /db_xref="EnsemblGenomes-Gn:BSU05900" /db_xref="EnsemblGenomes-Tr:CAB12409" /db_xref="GOA:O05514" /db_xref="InterPro:IPR006283" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10693" /db_xref="UniProtKB/Swiss-Prot:O05514" /translation="MDEFDLIHSITPRTIHHSSVDVGIGDDAALYTAKHGVQEIVCVD TMVEDVHFKLHYSSPEDIGYKALAVNISDIAAMGGIPKFYLVSLAVPSKWTESEIKAM YEGMNELAKLYHMDLIGGDTVSTADKLVVTVTVIGEIEKGQACLRSLAKPNDIVFVTG EIGSSAAGLSLLLEETNPQNSSVETDYFIHRHKRPEPRVSVGRLCSIFKRAALNDVSD GLASELNEIAEASCVSIEIVESMLPIHSDLPKLHPNWKEWALFGGEDFELTGTVSNEE WEVLKQECAALHLPITKIGYVREKTKSKVILKTDQTSMILEKKGYNHFK*" /label="thiL CDS" gene 576368..577345 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /label="thiL gene" CDS 577360..577836 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; ADP binding protein" /protein_id="NP_388472.1" /db_xref="EnsemblGenomes-Gn:BSU05910" /db_xref="EnsemblGenomes-Tr:CAB12410" /db_xref="GOA:O05515" /db_xref="InterPro:IPR003442" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12199" /db_xref="UniProtKB/Swiss-Prot:O05515" /translation="MKQLKWRTVNPEETKAIAKLTAAFAKPGDVLTLEGDLGAGKTTF TKGFAEGLGITRIVNSPTFTIIKEYNDGVLPLYHMDVYRMEDESEDLGLDEYFHGQGV CLVEWAHLIEEQLPQERLQIVIKRAGDDEREITFTAVGNRYEMLCEELSRHDNISN*" /label="tsaE CDS" gene 577360..577836 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /label="tsaE gene" CDS 577817..578506 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; protease involved in TsaD function" /protein_id="NP_388473.1" /db_xref="EnsemblGenomes-Gn:BSU05920" /db_xref="EnsemblGenomes-Tr:CAB12411" /db_xref="GOA:O05516" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR022496" /db_xref="SubtiList:BG12200" /db_xref="UniProtKB/Swiss-Prot:O05516" /translation="MTILAIDTSNYTLGIALLREDTVIAEYITYLKKNHSVRAMPAVH SLLNDCDMAPQDLSKIVVAKGPGSYTGVRIGVTLAKTLAWSLDIPISAVSSLETLAAN GRHFDGLISPIFDARRGQVYTGLYQYKNGLLEQVVPDQNVMLADWLEMLKEKDRPVLF LGHDTSLHKQMIEDVLGTKGFIGTAAQHNPRPSELAFLGKEKEAADVHGLVPDYLRLA EAEAKWIESQK*" /label="tsaB CDS" gene 577817..578506 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /label="tsaB gene" CDS 578516..578971 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /EC_number="2.3.1.267" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2828880; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein S18 alanine N-acetyltransferase" /protein_id="NP_388474.1" /db_xref="EnsemblGenomes-Gn:BSU05930" /db_xref="EnsemblGenomes-Tr:CAB12412" /db_xref="GOA:O05517" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR006464" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12201" /db_xref="UniProtKB/Swiss-Prot:O05517" /translation="MKTKAAVRNMRLEDIDHVYEIEASSFTSPWTKDSFYHELLENPY AHYLVIEKDGHLAGYCGIWIVMDDAQITNIAIKPEYRGQSLGETLFRSAVELCKEKDA RRLSLEVRVSNHPAQGLYKKFGMQPGGIRKNYYTDNGEDALIMWVTINE*" /label="rimI CDS" gene 578516..578971 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /label="rimI gene" CDS 578964..580004 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11073929, 12682299, 9743119, 20824107, 21625506, 21873492, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; glycation binding protein" /protein_id="NP_388475.1" /db_xref="EnsemblGenomes-Gn:BSU05940" /db_xref="EnsemblGenomes-Tr:CAB12413" /db_xref="GOA:O05518" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR017860" /db_xref="InterPro:IPR017861" /db_xref="InterPro:IPR022450" /db_xref="SubtiList:BG12202" /db_xref="UniProtKB/Swiss-Prot:O05518" /translation="MSEQKDMYVLGIETSCDETAAAIVKNGKEIISNVVASQIESHKR FGGVVPEIASRHHVEQITLVIEEAFRKAGMTYSDIDAIAVTEGPGLVGALLIGVNAAK ALSFAYNIPLVGVHHIAGHIYANRLVEDIVFPALALVVSGGHTELVYMKEHGSFEVIG ETLDDAAGEAYDKVARTMGLPYPGGPQIDKLAEKGNDNIPLPRAWLEEGSYNFSFSGL KSAVINTLHNASQKGQEIAPEDLSASFQNSVIDVLVTKTARAAKEYDVKQVLLAGGVA ANRGLRAALEKEFAQHEGITLVIPPLALCTDNAAMIAAAGTIAFEKGIRGAYDMNGQP GLELTSYQSLTR*" /label="tsaD CDS" gene 578964..580004 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /label="tsaD gene" downshifts 579968 /Source="Nicolas_upshifts" /id="D288" /incds=0 /nref=39 /ntot=222 /MaxReadThrough="3.15518" /MaxDrop="4.65228" /score="3.97936019" /energy="-10.1" /TU="NA" /idTUdmin="U460" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(580234..582162) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11916677, 16109936, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388476.2" /db_xref="EnsemblGenomes-Gn:BSU05950" /db_xref="EnsemblGenomes-Tr:CAB12414" /db_xref="GOA:O05519" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12203" /db_xref="UniProtKB/Swiss-Prot:O05519" /translation="MMILQVNQLSKSFGADTILNNIKLEVRNRDRIAIVGRNGAGKST LLKIIAGQLSYEKGEIIKPKDITMGYLAQHTGLDSKLTIKEELLTVFDHLKAMEKEMR AMEEKMAAADPGELESIMKTYDRLQQEFKDKGGYQYEADVRSVLHGLGFSHFDDSTQV QSLSGGQKTRLALGKLLLTQPDLLILDEPTNHLDIDTLTWLEHYLQGYSGAILIVSHD RYFLDKVVNQVYEVSRAESKKYHGNYSAYLDQKAAQYEKDLKMYEKQQDEIAKLQDFV DRNLARASTTKRAQSRRKQLERMDVMSKPLGDEKSANFHFDITKQSGNEVLRVQDLTI SYENQPPLLTEVSFMLTRGESAALVGPNGIGKSTLLKTLIDTLKPDQGTISYGSNVSV GYYDQEQAELTSSKRVLDELWDEYPGLPEKEIRTCLGNFLFSGDDVLKPVHSLSGGEK ARLALAKLMLQKANFLILDEPTNHLDLDSKEVLENALIDYPGTLLFVSHDRYFINRIA TRVLELSSSHIEEYLGDYDYYTEKKTEQLELEKMNQQEETDKTPATVKSDSKRSYEEE KEWKKKERQRLRRIEEIETTVQTIEENISRNDELLCDPEVYQDHEKVQAIHADNEKLN QELESLLSEWEELSTEED*" /label="ydiF CDS" gene complement(580234..582162) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /label="ydiF gene" downshifts complement(580251) /Source="Nicolas_upshifts" /id="D289" /incds=0 /nref=170 /ntot=266 /MaxReadThrough="1.32926" /MaxDrop="5.81869" /score="16.702581" /energy="-12.6" /TU="NA" /idTUdmin="U463" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" misc_feature 581914..581933 /Source="Nicolas_upshift_promotors" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 581924 /Source="Nicolas_upshifts" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" S_feature 581926..582115 /Source="Nicolas_S_feature" /locus_tag="new_646220_646409" /HighExp="Diami, H2O2, dia5, Paraq, G135, G180, G150, Cold, dia15, BC" /AntisenseName="ydiF" /AntisenseCor="0.47406689574609401" /AntisenseRegPval="-15.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S205" promotor_-35 582080..582087 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 582101..582120 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 582117..582287 /Source="Nicolas_S_feature" /locus_tag="new_646411_646581" /HighExp="Diami, dia5, dia15, H2O2, Etha, G180, G150, Oxctl, Mt0, Paraq" /AntisenseName="ydiF" /AntisenseCor="0.63697451027099605" /AntisenseRegPval="-31.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S206" upshifts 582117 /Source="Nicolas_upshifts" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(582182..582201) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(582194) /Source="Nicolas_upshifts" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(582215..582222) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 582288..582800 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /EC_number="4.6.1.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10903949, 16632608, 18607082, 20606263, 25941396, 26575208; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdenum cofactor biosynthesis protein C" /protein_id="NP_388477.1" /db_xref="EnsemblGenomes-Gn:BSU05960" /db_xref="EnsemblGenomes-Tr:CAB12415" /db_xref="GOA:O05520" /db_xref="InterPro:IPR002820" /db_xref="InterPro:IPR023045" /db_xref="InterPro:IPR036522" /db_xref="SubtiList:BG12204" /db_xref="UniProtKB/Swiss-Prot:O05520" /translation="MNGFSHFNEQGRAQMVDISEKSSTVRTAAAVSSVHMKNEVYEKI QSHDIGKGDVLAVAQVAGIMAAKQTSNIIPMCHPLSLSGVDISFDWKIKEAEVILHIK AQVKTKGSTGVEMEALTSASVCALTVYDMCKALDKGMVIGPTFLLEKTGGKNGDFKRE LSEYNLEDQK*" /label="moaC CDS" gene 582288..582800 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /label="moaC gene" CDS 582797..583444 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription repressor of cydABCD and yjlC-ndh expression" /protein_id="NP_388478.1" /db_xref="EnsemblGenomes-Gn:BSU05970" /db_xref="EnsemblGenomes-Tr:CAB12416" /db_xref="GOA:O05521" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR009718" /db_xref="InterPro:IPR022876" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2VT2" /db_xref="PDB:2VT3" /db_xref="SubtiList:BG12205" /db_xref="UniProtKB/Swiss-Prot:O05521" /translation="MNKDQSKIPQATAKRLPLYYRFLKNLHASGKQRVSSAELSDAVK VDSATIRRDFSYFGALGKKGYGYNVDYLLSFFRKTLDQDEMTDVILIGVGNLGTAFLH YNFTKNNNTKISMAFDINESKIGTEVGGVPVYNLDDLEQHVKDESVAILTVPAVAAQS ITDRLVALGIKGILNFTPARLNVPEHIRIHHIDLAVELQSLVYFLKHYSVLEEIE*" /label="rex CDS" gene 582797..583444 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /label="rex gene" promotor_no_box 583274..583374 /Source="Nicolas_upshift_promotors" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 583334 /Source="Nicolas_upshifts" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" CDS 583466..583639 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388479.1" /db_xref="EnsemblGenomes-Gn:BSU05980" /db_xref="EnsemblGenomes-Tr:CAB12417" /db_xref="GOA:O05522" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG12206" /db_xref="UniProtKB/Swiss-Prot:O05522" /translation="MPIGPGSLAVIAIVALIIFGPKKLPELGKAAGDTLREFKNATKG LTSDEEEKKKEDQ*" /label="tatAY CDS" gene 583466..583639 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /label="tatAY gene" CDS 583646..584410 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11007775, 15187182, 15849754, 16850406, 19049517, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007775, 15187182, 15849754, 16850406, 19049517, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388480.1" /db_xref="EnsemblGenomes-Gn:BSU05990" /db_xref="EnsemblGenomes-Tr:CAB12418" /db_xref="GOA:O05523" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG12207" /db_xref="UniProtKB/Swiss-Prot:O05523" /translation="MTRMKVNQMSLLEHIAELRKRLLIVALAFVVFFIAGFFLAKPII VYLQETDEAKQLTLNAFNLTDPLYVFMQFAFIIGIVLTSPVILYQLWAFVSPGLYEKE RKVTLSYIPVSILLFLAGLSFSYYILFPFVVDFMKRISQDLNVNQVIGINEYFHFLLQ LTIPFGLLFQMPVILMFLTRLGIVTPMFLAKIRKYAYFTLLVIAALITPPELLSHMMV TVPLLILYEISILISKAAYRKAQKSSAADRDVSSGQ*" /label="tatCY CDS" gene 583646..584410 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /label="tatCY gene" downshifts 584390 /Source="Nicolas_upshifts" /id="D290" /incds=0 /nref=151 /ntot=251 /MaxReadThrough="4.01237" /MaxDrop="6.80817" /score="19.4098216" /energy="-12.7" /TU="NA" /idTUdmin="U461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(584448..584639) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388481.1" /db_xref="EnsemblGenomes-Gn:BSU06000" /db_xref="EnsemblGenomes-Tr:CAB12419" /db_xref="GOA:O05524" /db_xref="InterPro:IPR025426" /db_xref="SubtiList:BG12208" /db_xref="UniProtKB/Swiss-Prot:O05524" /translation="MRNPVVWGMIYFAVGCIFTYLAASSPGSMWSFYSILLMVFAAYN ISISFKMFAFSFKIKKNQK*" /label="ydiK CDS" gene complement(584448..584639) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /label="ydiK gene" downshifts complement(584465) /Source="Nicolas_upshifts" /id="D291" /incds=0 /nref=211 /ntot=258 /MaxReadThrough="0.81338" /MaxDrop="6.43897" /score="25.5376889" /energy="-12.7" /TU="NA" /idTUdmin="U467" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(584636..585370) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /EC_number="3.4.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_388482.1" /db_xref="EnsemblGenomes-Gn:BSU06010" /db_xref="EnsemblGenomes-Tr:CAB12420" /db_xref="GOA:O05525" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG12209" /db_xref="UniProtKB/Swiss-Prot:O05525" /translation="MRKQYWFIILTYIIMQFSALIAIPLLFKFGYAGGQPTDENMLHA QGLWSVISFIACLVVVLLILRTVPKETLRNGQKDSIGLSILWAIAGFFIALFSQGIAG SIEYYVFGIGRESENTQAILDVIQAVPLMIIVSSIVGPILEEIIFRKIIFGALYEKTN FFFAGLISSVIFGIVHADLKHLLLYTAMGFTFAFLYARTKRIWVPIFAHLMMNTFVVI MQLEPVRNYLEQQSTQMQLIIGGLFL*" /label="ydiL CDS" gene complement(584636..585370) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /label="ydiL gene" promotor_-35 585028..585033 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 585048..585066 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 585050 /Source="Nicolas_upshifts" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 585369..585370 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-35" promotor_-10 585380..585394 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-10" upshifts 585402 /Source="Nicolas_upshifts" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="upshifts" promotor_-10 complement(585407..585426) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 585424..585532 /Source="Nicolas_S_feature" /locus_tag="new_649718_649826" /HighExp="S4, S5, H2O2, S3, S8, S6, Diami, Oxctl, G180, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.238" /TUlongSig="NA" /TUlongPSig="NA" /label="S207" upshifts complement(585427) /Source="Nicolas_upshifts" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(585440..585445) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 585506..585512 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 585526..585545 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 585534..585608 /Source="Nicolas_S_feature" /locus_tag="new_649828_649902" /HighExp="HiTm, Etha, dia15, Heat, C90, dia5, LoTm, Lbexp, H2O2, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S208" upshifts 585534 /Source="Nicolas_upshifts" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="upshifts" CDS 585609..585893 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11407116, 17031040, 9303302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11407116, 17031040, 9303302; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin small subunit" /protein_id="NP_388483.2" /db_xref="EnsemblGenomes-Gn:BSU06020" /db_xref="EnsemblGenomes-Tr:CAB12421" /db_xref="GOA:P28599" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR018369" /db_xref="InterPro:IPR020818" /db_xref="InterPro:IPR037124" /db_xref="SubtiList:BG10422" /db_xref="UniProtKB/Swiss-Prot:P28599" /translation="MLKPLGDRVVIELVESEEKTASGIVLPDSAKEKPQEGKIVAAGS GRVLESGERVALEVKEGDRIIFSKYAGTEVKYEGTEYLILRESDILAVIG*" /label="groES CDS" gene 585609..585893 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /label="groES gene" CDS 585940..587574 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9303302, 11407116, 17031040, 17420574, 22268681" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 11407116, 17031040, 17420574, 22268681; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin large subunit" /protein_id="NP_388484.1" /db_xref="EnsemblGenomes-Gn:BSU06030" /db_xref="EnsemblGenomes-Tr:CAB12422" /db_xref="GOA:P28598" /db_xref="InterPro:IPR001844" /db_xref="InterPro:IPR002423" /db_xref="InterPro:IPR018370" /db_xref="InterPro:IPR027409" /db_xref="InterPro:IPR027410" /db_xref="InterPro:IPR027413" /db_xref="SubtiList:BG10423" /db_xref="UniProtKB/Swiss-Prot:P28598" /translation="MAKEIKFSEEARRAMLRGVDALADAVKVTLGPKGRNVVLEKKFG SPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREG LKNVTAGANPVGVRKGMEQAVAVAIENLKEISKPIEGKESIAQVAAISAADEEVGSLI AEAMERVGNDGVITIEESKGFTTELEVVEGMQFDRGYASPYMVTDSDKMEAVLDNPYI LITDKKITNIQEILPVLEQVVQQGKPLLLIAEDVEGEALATLVVNKLRGTFNAVAVKA PGFGDRRKAMLEDIAVLTGGEVITEDLGLDLKSTQIAQLGRASKVVVTKENTTIVEGA GETDKISARVTQIRAQVEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKL RIEDALNSTRAAVEEGIVSGGGTALVNVYNKVAAVEAEGDAQTGINIVLRALEEPIRQ IAHNAGLEGSVIVERLKNEEIGVGFNAATGEWVNMIEKGIVDPTKVTRSALQNAASVA AMFLTTEAVVADKPEENGGGAGMPDMGGMGGMGGMM*" /label="groEL CDS" gene 585940..587574 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /label="groEL gene" S_feature 587575..587667 /Source="Nicolas_S_feature" /locus_tag="new_651869_651961" /HighExp="HiTm, Etha, dia15, Heat, Diami, dia5, C90, S1, S2, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S209" downshifts 587624 /Source="Nicolas_upshifts" /id="D292" /incds=0 /nref=228 /ntot=267 /MaxReadThrough="6.24882" /MaxDrop="5.77437" /score="-6.71161833" /energy="-16.3" /TU="U468" /idTUdmin="U466" /TUdmin=2112 /isTUend="FALSE" /label="downshifts" CDS complement(587662..587790) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); C-terminal part of YdzT; defective prophage 3" /translation="EAGVGIKEIQQQFGHSDINTTMDIYAHMTANMEKRSPNSLVN*" /label="ydzTc CDS" gene complement(587662..587790) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /pseudo /label="ydzTc gene" S_feature 587669..>588895 /Source="Nicolas_S_feature" /locus_tag="new_651963_653431" /HighExp="H2O2, Heat, dia15, Diami, S1, G135, G150, S2, G180, dia5" /AntisenseName="ydzT" /AntisenseCor="-2.9485116084752801E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="0.23100000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S210" CDS complement(587793..587951) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52563.1" /translation="MIYQDSSFIFEREDGHPQLRKVIETRLKRLLKKAGIKRMSPPTL LGIPIPPY*" /label="ydzT CDS" gene complement(587793..587951) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /pseudo /label="ydzT gene" CDS complement(587996..588124) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52564.1" /translation="MISQVTKTLYTPNNQIEKYQLLTPKTTGSVDIVRIDETMSIY*" /label="ydzT CDS" gene complement(587996..588124) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /pseudo /label="ydzT gene" CDS complement(588217..588426) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52565.1" /translation="MYEDRTLELNEQYSHNCLGGIHACGRMIFRKAKTQGIIKMNPTG DFQLPKKQQSIGKRGADTFSKARSI*" /label="ydzT CDS" gene complement(588217..588426) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /pseudo /label="ydzT gene" CDS complement(588419..588724) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); N-terminal part of YdzT; defective prophage 3" /db_xref="PSEUDO:CAX52566.1" /translation="MELSYLLGIDPLTKKRLEISKGRFKTKKEAPVAARHVELQNDNG TFIKESDMPFKTFAKGWLKIYNRSGVKISSVRASEKKMMHFIAVLGQYPISKTQKNV* " /label="ydzTn CDS" gene complement(588419..588724) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /pseudo /label="ydzTn gene" SCAR join(588895,588902) /created_by="AR/SM" /note="deletion occured in betwen marked nucleotides" /label="Delta6_1" N_region 588896..588901 /note="KpnI site (GGTACC)" /created_by="User" /label="Delta6_1" CDS complement(589000..591489) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11118449, 11390381, 12897001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11118449, 11390381, 12897001; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the glucitol operon" /protein_id="NP_388495.1" /db_xref="EnsemblGenomes-Gn:BSU06140" /db_xref="EnsemblGenomes-Tr:CAB12433" /db_xref="GOA:P39143" /db_xref="InterPro:IPR002182" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR024123" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10178" /db_xref="UniProtKB/Swiss-Prot:P39143" /translation="MAELENRKQFAQMLAPGVKTLKLHPDYKVRRKKNEKTGQSYIDK IALQLGVSPNTIKSWIGQMGANYIPGRIDDGKLFGMIWIILEKTDLDIEWLTDLLEAT TIPVIKPALPVWAASCLKKAKILRKDGLFGAPSEGEIENVVKRLFHDRPGQETNALTE QPITHNLPSRWSGRFIGRSFDMEAIRQWMLSPSPVCLITGWAGMGKTTIALEAAYSCV DDTSVWPAFNSIIWVSADWKGLSFSDFLNTIAYQLGRKEQIDKSINVKRFVVRNALAN YTREKPILLIVDSIDTAERDIHEFITSLPQGVKVLLTARENVKQTYRESFGEMTAIQL SGLDQTDAHEFFQQEVHHCLQTCNLPRKREKLEQLLHLSSDLKNEFISATAGNPKAMA LSIAYMSDDDIPAQQLIHELGKAGYSLLELFEFLFGRTWDRCNEDTRKLWQTLCFFSK PPDEKSLAAAAGLDARRFHYAMEQMRSYALIQPERSQGRTQYLAHQTVVAYGEQHLSE QHEYEKEARNRWAHYYIDYAETHLKREQPNSIYWSYLLGRNLDQMKQEWPNILKVIQW ASETEQKEILIELITRISHFLSRINLPLRIEYGRKAADAAHHLGQHTREAYFRIDTSG WALMEVNDLDGALQQIEAGLKILEQSDAHDAYDLKVWGHALKARLFLKDGQQEKAETI LNEIENQPISPTIQHRVLLVRGDLSFARGYHVEAIQLYEAANEISSTYGGEKTIEAYF NLGVAYVKCDQFEKAEEAFEQMLYDKHNANQVELIYYHYGMAQLLYRKGEKTKAVESN QKAIRLIDSWEPAIGIRGEVERLARATKENE*" /label="gutR CDS" gene complement(589000..591489) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /label="gutR gene" downshifts complement(589022) /Source="Nicolas_upshifts" /id="D298" /incds=0 /nref=56 /ntot=209 /MaxReadThrough="0.69715" /MaxDrop="4.256" /score="0.285109352" /energy="-13.9" /TU="NA" /idTUdmin="U474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(591503..591522) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(591529) /Source="Nicolas_upshifts" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(591536..591543) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 591592..591593 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 591608..591690 /Source="Nicolas_S_feature" /locus_tag="new_667383_667465" /HighExp="Lbstat, BI, M40t90, Mt0, M0t90, dia5, dia0, Lbexp, Lbtran, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.848" /TUlongSig="NA" /TUlongPSig="NA" /label="S220" upshifts 591608 /Source="Nicolas_upshifts" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 591609..591628 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 591691..592752 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /EC_number="1.1.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1460002, 8195086, 8195087, 12897001, 19784641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1460002, 8195086, 8195087, 12897001, 19784641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucitol (sorbitol) dehydrogenase" /protein_id="NP_388496.1" /db_xref="EnsemblGenomes-Gn:BSU06150" /db_xref="EnsemblGenomes-Tr:CAB12434" /db_xref="GOA:Q06004" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10177" /db_xref="UniProtKB/Swiss-Prot:Q06004" /translation="MTHTVPQNMKAAVMHNTREIKIETLPVPDINHDEVLIKVMAVGI CGSDLHYYTNGRIGNYVVEKPFILGHECAGEIAAVGSSVDQFKVGDRVAVEPGVTCGR CEACKEGRYNLCPDVQFLATPPVDGAFVQYIKMRQDFVFLIPDSLSYEEAALIEPFSV GIHAAARTKLQPGSTIAIMGMGPVGLMAVAAAKAFGAGTIIVTDLEPLRLEAAKKMGA THIINIREQDALEEIKTITNDRGVDVAWETAGNPAALQSALASVRRGGKLAIVGLPSQ NEIPLNVPFIADNEIDIYGIFRYANTYPKGIEFLASGIVDTKHLVTDQYSLEQTQDAM ERALQFKNECLKVMVYPNR*" /label="gutB CDS" gene 591691..592752 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /label="gutB gene" CDS 592826..594217 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897001, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+-glucitol symporter; prophage region 3" /protein_id="NP_388497.1" /db_xref="EnsemblGenomes-Gn:BSU06160" /db_xref="EnsemblGenomes-Tr:CAB12435" /db_xref="GOA:O34368" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12795" /db_xref="UniProtKB/Swiss-Prot:O34368" /translation="MIGTEKVTALKAKHQSKSSTGLSWFERIGYGFGDMSYNIIFQFV NAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLWV AFPFALFTFLCFTTPHFGETGNMVYAYVTYILLGMSFSMQTIPVNSLTGRMTNSVEER TVLTTTRMILVYIGILLSISCATPLATAIGGEDQAFGFQMTALIYAAVSIVLNLFSFF TVRERIQPKKRKKQGIKKTLSVLFKNKPLLMLISSFLAFAIGFNIKLSTMVYYFTYNV NHKEFVFMGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAALSLISYAGLHFTPYSS IPLIFIWLFASGFFTTPLNTLAWGMVADCVDYAEWKTGIRADGVVISSMSFINKLGVA LAGSFSAIYLGIAGYVANTDQTVASLNAIKNMNALIPGFFILLSIILIAFYPLTEKRY KHIISELEQRSAR*" /label="gutP CDS" gene 592826..594217 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /label="gutP gene" promotor_-35 594244..594251 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 594265..594284 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 594270 /Source="Nicolas_upshifts" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="upshifts" CDS 594312..595274 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26483775, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar kinase (ribokinase family); prophage region 3" /protein_id="NP_388498.1" /db_xref="EnsemblGenomes-Gn:BSU06170" /db_xref="EnsemblGenomes-Tr:CAB12436" /db_xref="GOA:O34768" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12796" /db_xref="UniProtKB/Swiss-Prot:O34768" /translation="MRSHSVVCIGELLIDFFCTDVDVDLMEGRQFLKSAGGAPANVSA AIAKLGGDAAFSGKVGKDPFGYFLKRTLDAVHVDTSMLVMDEKAPTTLAFVSLKQNGE RDFVFNRGADALFTLEDIDQEKLNEAKILHFGSATALLSDPFCSAYLRLMSIAKDNGQ FISFDPNYREDLWRGRVSEFVSVAKKAIAVSDFVKVSDEELEIISGVKDHEKGVAILH EIGANIVAVTLGKSGTLLSNGKDREIIPSIPVTSIDSTGAGDAFVGAALYQLANTDQI QSVDADFVKLREIVAFANKVGALVCTKIGAIDALPSLDEIGVSL*" /label="ydjE CDS" gene 594312..595274 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /label="ydjE gene" downshifts 595259 /Source="Nicolas_upshifts" /id="D299" /incds=0 /nref=86 /ntot=213 /MaxReadThrough="2.99546" /MaxDrop="4.52045" /score="16.4550614" /energy="-14" /TU="NA" /idTUdmin="U475" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 595399..595408 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 595415 /Source="Nicolas_upshifts" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 595421..595436 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 595470..596153 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11454200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11454200; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage shock protein A homolog regulator; prophage region 3" /protein_id="NP_388499.1" /db_xref="EnsemblGenomes-Gn:BSU06180" /db_xref="EnsemblGenomes-Tr:CAB12437" /db_xref="GOA:P54617" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG12797" /db_xref="UniProtKB/Swiss-Prot:P54617" /translation="MSIIGRFKDIMSANINALLDKAENPEKMVDQYLRNMNSDLAKVK AETAAVMAEEQRAKREYHECQADMEKMESYAMKALQAGNESDARKFLERKTSLESKLS ELQAANQIAATNAAQMRKMHDKLVSDIGELEARKNMIKAKWAVAKTQERMNKLGASVS STSQSMSAFGRMEDKVNKALDQANAMAELNSAPQDDMADLSAKYDTGGSSQVDDELAA LKAKMMLDK*" /label="pspA CDS" gene 595470..596153 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /label="pspA gene" S_feature 596154..596218 /Source="Nicolas_S_feature" /locus_tag="new_671929_671993" /HighExp="Salt, S0, aero, T-0.40H, T-1.40H, SMMPr, T-1.10H, T0.0H, Cold, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S221" CDS 596219..597244 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /function="16.5: Explore" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage replication protein; prophage region 3" /protein_id="NP_388500.1" /db_xref="EnsemblGenomes-Gn:BSU06190" /db_xref="EnsemblGenomes-Tr:CAB12438" /db_xref="GOA:O34434" /db_xref="InterPro:IPR013137" /db_xref="SubtiList:BG12798" /db_xref="UniProtKB/Swiss-Prot:O34434" /translation="MIISYKCPNCGSDMAFDSETGSLSCSSCGRQDNIESLPKENIAA RFSDDEAKEYQCKNCGAVLITEAETTATTCSFCGGAAILADRLSGHLAPAKVIPFTIS KQEAEQAFRKWCKKGLLTPRGFMSADRIKSITGMYIPFWMFDLNSEVQVRANCTRVHQ YEEGDYICTETEHFEAFRDINLDYLKIPVDASEKMKDELMDKLEPYSYEELKDFQTAY LAGYIAEKYNYTDEELFPRAKEKISSYIDSYIHSTFSGYTSVNVRDKHIHTKNVNSFY VLLPVWMVSYDYERAEHIFAMNGQTGKVVGKPPISRGKVAAWFSGIAGGTFLALKLVS LMMGGGF*" /label="ydjG CDS" gene 596219..597244 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /label="ydjG gene" CDS 597244..598008 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; prophage region 3" /protein_id="NP_388501.1" /db_xref="EnsemblGenomes-Gn:BSU06200" /db_xref="EnsemblGenomes-Tr:CAB12439" /db_xref="GOA:O35004" /db_xref="InterPro:IPR007621" /db_xref="SubtiList:BG12799" /db_xref="UniProtKB/Swiss-Prot:O35004" /translation="MRGFFGKAIFVVLAVFIMMPLLGIEAVRASELQQHVYDRAHLLS KAEIGKLESLSAKLGAKRDTDFIIITTKSTNGEDIADYTGDFYDRYGKGSTAILTIDM TNREVFIAGFKKAEQYLDNSRLNSIRNTISSDLSNENYFEAFETYIQLSYKDMGIKPG VNPDNIFFTWWFQLIAAIAVGGIAVSIMLYHAGGKVTVNGSTYMDQRTSDVIDQYDTY IRTTVTRERKPSDKDSGSDGGVTKGGTSYSGSRGSF*" /label="ydjH CDS" gene 597244..598008 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /label="ydjH gene" CDS 598039..599010 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388502.1" /db_xref="EnsemblGenomes-Gn:BSU06210" /db_xref="EnsemblGenomes-Tr:CAB12440" /db_xref="InterPro:IPR033880" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG12800" /db_xref="UniProtKB/Swiss-Prot:O34789" /translation="MSFFRNQLANVVEWEEFRDDMIFYKWNNREIKKGSRLIIRPGQD AVFLNNGRVEGVFQDDGDYDIESEIIPFLSTLKGFKFGFNSGMRAEVLFVNTKEFTVR WGTKQAINIPAAGMPGGMPIRANGTFNFKVQDYISLIDKIAGVKDQYFVEDIKTRIIS ILDQLLMKWITREGKDMFNLQANAFDIAKGIQEDLDMQLISDGMTVTGFQIMSFNYPQ EVQDMITKNASYGMVGDVNRYQQISMTDGMASGKMSGSGAASDMAGMMMGMNMANQMM NQMNQNQQAQSSGPQSTGSGSKPNFCPNCGTKTGEANFCPNCGQKLV*" /label="ydjI CDS" gene 598039..599010 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /label="ydjI gene" downshifts 599000 /Source="Nicolas_upshifts" /id="D300" /incds=0 /nref=180 /ntot=247 /MaxReadThrough="2.71622" /MaxDrop="5.81579" /score="16.72046" /energy="-11.1" /TU="U477" /idTUdmin="U477" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 599044 /Source="Nicolas_upshifts" /id="D301" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="2.13813" /MaxDrop="3.25329" /score="16.72046" /energy="-11.1" /TU="NA" /idTUdmin="U477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(599057..600082) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane associated potassium channel; prophage region 3" /protein_id="NP_388503.1" /db_xref="EnsemblGenomes-Gn:BSU06220" /db_xref="EnsemblGenomes-Tr:CAB12441" /db_xref="GOA:O34733" /db_xref="InterPro:IPR013099" /db_xref="SubtiList:BG12801" /db_xref="UniProtKB/Swiss-Prot:O34733" /translation="MNEGYIIAGLLLLTAGMIDFLWTTLWLESGAGPITRCLSAWLWK GCRKISGDHAKVLSMAGPLLLCLTLVIWISLFWSGWVLIYSSDPHSLMETQSKEPASW SDRIYFSGYVMFTLGNGDLAPNGGLWKLVTIIETAQGLLTITFSVTYLISVLSAVNQK RSFAQSVLSLGHDGTEIVHNAWNGKDFHDIDFLLVAASSELGKLTAQHNAFPILHFYH STQHQESSIIAVAVLDEALTIFKYGIPEQYQPNQLHIKEARSSIKNYLDTVHTAYIHP AEQAPPEPDISKLQQSGIPALSKQTFQIAVNSIKERRQLLLGIIQAGARKWPVQEQAI GNAYSPK*" /label="ydjJ CDS" gene complement(599057..600082) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /label="ydjJ gene" promotor_-10 complement(600114..600133) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(600132) /Source="Nicolas_upshifts" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(600147..600153) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 600342..600349 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 600362 /Source="Nicolas_upshifts" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="upshifts" S_feature 600364..600666 /Source="Nicolas_S_feature" /locus_tag="new_676139_676441" /HighExp="M0t90, M40t90, Lbtran, T0.30H, BI, T1.0H, M9-stat, S1, T1.30H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.28450700000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S222" promotor_-10 600364..600383 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 600667..602088 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="myo-inositol transporter" /protein_id="NP_388504.1" /db_xref="EnsemblGenomes-Gn:BSU06230" /db_xref="EnsemblGenomes-Tr:CAB12442" /db_xref="GOA:O34718" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12802" /db_xref="UniProtKB/Swiss-Prot:O34718" /translation="MNKQGNQMSFLRTIILVSTFGGLLFGYDTGVLNGALPYMGEPDQ LNLNAFTEGLVTSSLLFGAALGAVFGGRMSDFNGRRKNILFLAVIFFISTIGCTFAPN VTVMIISRFVLGIAVGGASVTVPAYLAEMSPVESRGRMVTQNELMIVSGQLLAFVFNA ILGTTMGDNSHVWRFMLVIASLPALFLFFGMIRMPESPRWLVSKGRKEDALRVLKKIR DEKRAAAELQEIEFAFKKEDQLEKATFKDLSVPWVRRIVFIGLGIAIVQQITGVNSIM YYGTEILRNSGFQTEAALIGNIANGVISVLATFVGIWLLGRVGRRPMLMTGLIGTTTA LLLIGIFSLVLEGSPALPYVVLSLTVTFLAFQQGAISPVTWLMLSEIFPLRLRGLGMG VTVFCLWMVNFAVSFTFPILLAAIGLSTTFFIFVGLGICSVLFVKRFLPETKGLSLEQ LEENFRAYDHSGAKKDSGAEVIG*" /label="iolT CDS" gene 600667..602088 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /label="iolT gene" downshifts 602080 /Source="Nicolas_upshifts" /id="D302" /incds=0 /nref=11 /ntot=24 /MaxReadThrough="2.82455" /MaxDrop="8.02371" /score="11.3880907" /energy="-11.2" /TU="NA" /idTUdmin="U479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(602136) /Source="Nicolas_upshifts" /id="D303" /incds=0 /nref=242 /ntot=272 /MaxReadThrough="1.00274" /MaxDrop="9.32541" /score="13.6781112" /energy="-11.2" /TU="NA" /idTUdmin="U482" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(602136..603176) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /EC_number="1.1.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12469342, 18820069, 24525333, 26428232, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12469342, 18820069, 24525333, 26428232, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin reductase/2,3-butanediol dehydrogenase" /protein_id="NP_388505.1" /db_xref="EnsemblGenomes-Gn:BSU06240" /db_xref="EnsemblGenomes-Tr:CAB12443" /db_xref="GOA:O34788" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12803" /db_xref="UniProtKB/Swiss-Prot:O34788" /translation="MKAARWHNQKDIRIEHIEEPKTEPGKVKIKVKWCGICGSDLHEY LGGPIFIPVDKPHPLTNETAPVTMGHEFSGEVVEVGEGVENYKVGDRVVVEPIFATHG HQGAYNLDEQMGFLGLAGGGGGFSEYVSVDEELLFKLPDELSYEQGALVEPSAVALYA VRSSKLKAGDKAAVFGCGPIGLLVIEALKAAGATDIYAVELSPERQQKAEELGAIIVD PSKTDDVVAEIAERTGGGVDVAFEVTGVPVVLRQAIQSTTIAGETVIVSIWEKGAEIH PNDIVIKERTVKGIIGYRDIFPAVLSLMKEGYFSADKLVTKKIVLDDLIEEGFGALIK EKSQVKILVRPN*" /label="bdhA CDS" gene complement(602136..603176) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /label="bdhA gene" promotor_-35 602716..602725 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 602739..602758 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 602740..603275 /Source="Nicolas_S_feature" /locus_tag="new_678515_679050" /HighExp="C30, Gly, S6, C90, S8, BT, S7, Sw, Fru, Lbstat" /AntisenseName="bdhA" /AntisenseCor="-0.174163895138467" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S223" upshifts 602740 /Source="Nicolas_upshifts" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(603177..603471) /Source="Nicolas_S_feature" /locus_tag="new_678952_679246_c" /HighExp="Lbtran, BI, T1.0H, M40t90, LBGstat, LoTm, T0.30H, LPhT, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S224" misc_feature 603276..603295 /Source="Nicolas_upshift_promotors" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 603277..603574 /Source="Nicolas_S_feature" /locus_tag="new_679052_679349" /HighExp="G180, Paraq, Oxctl, H2O2, G135, G150, MG 5, C30, UNK1, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S225" upshifts 603277 /Source="Nicolas_upshifts" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="upshifts" misc_feature complement(603466..603480) /Source="Nicolas_upshift_promotors" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(603471) /Source="Nicolas_upshifts" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 603573..603592 /Source="Nicolas_upshift_promotors" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 603576 /Source="Nicolas_upshifts" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="upshifts" CDS 603615..603986 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /experiment="publication(s) with functional evidences, PMID:17581128, 20487291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17581128, 20487291; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein involved in cell wall metabolism" /protein_id="NP_388506.1" /db_xref="EnsemblGenomes-Gn:BSU06250" /db_xref="EnsemblGenomes-Tr:CAB12444" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG11036" /db_xref="UniProtKB/Swiss-Prot:P40775" /translation="MLKKVILAAFILVGSTLGAFSFSSDASAKHVNGNITWYNGVGKK GSSGKKLGHWDCATKIGFDVPRNGTKIRAYAKAKPKKVITVYKNDVGRMPNAVLDVSP KAFKALGYPLSKGKVAGHYSY*" /label="walM CDS" gene 603615..603986 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /label="walM gene" downshifts 603972 /Source="Nicolas_upshifts" /id="D304" /incds=0 /nref=5 /ntot=52 /MaxReadThrough="5.74148" /MaxDrop="2.8439" /score="-1.55787542" /energy="-7.4" /TU="U483" /idTUdmin="U481" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS 604052..605098 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388507.1" /db_xref="EnsemblGenomes-Gn:BSU06260" /db_xref="EnsemblGenomes-Tr:CAB12445" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12804" /db_xref="UniProtKB/Swiss-Prot:O34353" /translation="MKKRIILLLAVIIAAAAAGVAFYVAKDKGHEKAADVSVNTESGD ELLVSITDTDLLTKYYENDKVIHEEKLTSYPAFALDQKQQVLYYTGNNEQNEMRLFKL DLKSHKKTMLYKGAESADSLFLSKDRSTIYFRLGKADESNFRIAAFDLKTKKYKNLYP AANDQDDTVSSFFYNQKNDSFALLHYSVEEDYKKTDEANEKGIDPEPTTIHFAEGRQN KFNELKSLNQFISDIAVSDDDKRILFTSYTQKGTEQTASIQMLNADTKKYESIISNQK SFKLLIDAQPQFSKDGKNIYFLAEAKGAKKLKDETGREAKVRTIYSYSLENKTFKKVW ENPNGIINSFFVIN*" /label="ydjN CDS" gene 604052..605098 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /label="ydjN gene" downshifts 605072 /Source="Nicolas_upshifts" /id="D305" /incds=0 /nref=41 /ntot=177 /MaxReadThrough="1.73572" /MaxDrop="4.49184" /score="21.8200083" /energy="-13.9" /TU="NA" /idTUdmin="U483" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(605132..605290) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097689.1" /db_xref="EnsemblGenomes-Gn:BSU06269" /db_xref="EnsemblGenomes-Tr:CAX52576" /db_xref="GOA:O24817" /db_xref="UniProtKB/Swiss-Prot:O24817" /translation="MISNQQQKDLKKRAAFKKLNVAMNSYVELLFLSVPLIHIFKWLG SLALHLIH*" /label="ydzJ CDS" gene complement(605132..605290) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /label="ydzJ gene" downshifts complement(605148) /Source="Nicolas_upshifts" /id="D306" /incds=0 /nref=23 /ntot=155 /MaxReadThrough="0.7906" /MaxDrop="3.61386" /score="9.10659473" /energy="-10.1" /TU="NA" /idTUdmin="U487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(605347..605479) /Source="Nicolas_S_feature" /locus_tag="new_681122_681254_c" /HighExp="LoTm, S8, S5, S6, S4, B36, S7, Cold, B60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigWXY" /TUshortPSig="0.994, 1, 1" /TUlongSig="SigK" /TUlongPSig="0.994" /label="S226" downshifts complement(605390) /Source="Nicolas_upshifts" /id="D307" /incds=0 /nref=57 /ntot=272 /MaxReadThrough="3.03092" /MaxDrop="6.46708" /score="5.41743429" /energy="-8.4" /TU="U484,U486,U487" /idTUdmin="U484" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(605480..605689) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28197687" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388508.1" /db_xref="EnsemblGenomes-Gn:BSU06270" /db_xref="EnsemblGenomes-Tr:CAB12446" /db_xref="InterPro:IPR025916" /db_xref="SubtiList:BG12805" /db_xref="UniProtKB/Swiss-Prot:O34759" /translation="MSYYNKRNQEPLPKEDVSTWECTKEDCNGWTRKNFASSDTPLCP LCGSKMVDGIRSLVNLQNNSQTKTS*" /label="ydjO CDS" gene complement(605480..605689) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /label="ydjO gene" promotor_-10 complement(605722..605741) /Source="Nicolas_upshift_promotors" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(605733) /Source="Nicolas_upshifts" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" CDS complement(605772..606587) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9987136; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacrylate hydrolase" /protein_id="NP_388509.1" /db_xref="EnsemblGenomes-Gn:BSU06280" /db_xref="EnsemblGenomes-Tr:CAB12447" /db_xref="GOA:O34592" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12806" /db_xref="UniProtKB/Swiss-Prot:O34592" /translation="MPYIILEDQTRLYYETHGSGTPILFIHGVLMSGQFFHKQFSVLS ANYQCIRLDLRGHGESDKVLHGHTISQYARDIREFLNAMELDHVVLAGWSMGAFVVWD YLNQFGNDNIQAAVIIDQSASDYQWEGWEHGPFDFDGLKTAMHAIQTDPLPFYESFIQ NMFAEPPAETETEWMLAEILKQPAAISSTILFNQTAADYRGTLQNINVPALLCFGEDK KFFSTAAGEHLRSNIPNATLVTFPKSSHCPFLEEPDAFNSTLLSFLDGVIGKS*" /label="ydjP CDS" gene complement(605772..606587) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /label="ydjP gene" promotor_-35 606414..606423 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 606436..606455 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 606436 /Source="Nicolas_upshifts" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(606600..607589) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388510.1" /db_xref="EnsemblGenomes-Gn:BSU06290" /db_xref="EnsemblGenomes-Tr:CAB12448" /db_xref="InterPro:IPR025062" /db_xref="SubtiList:BG12210" /db_xref="UniProtKB/Swiss-Prot:O34803" /translation="MLTHDLHEKTKHYISIYAELKTKLKWKVSHDQILMLISSAYIVN KREFDFQRFYDLSSYIKSNIGSFSTLNSHHRFTVASILDIHFQHEAKQTFQTFIDVYN EMVKLGYKRDMFTYLSALILLTGKSETTNQKEQMNMGLAVYQQMKKNHYFLTSTQNVP LAVLLGENGKGLQALQKAETCYQLLAANGFKKGQYLHQVSHILALQSEKEPEMLVSAC KQIYQSITESVKKTKDYHYPDLALLTFLEEPDIKTVLCITDELNQEKAFKWQKEMNFK IAVSLYLSEHMEKNLLMESGLYTAIETVIQAQQAAATAAIISSTAASHTHDGN*" /label="yeaA CDS" gene complement(606600..607589) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /label="yeaA gene" promotor_-10 complement(607454..607472) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(607462) /Source="Nicolas_upshifts" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(607488..607493) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(607611..607626) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(607632) /Source="Nicolas_upshifts" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(607638..607647) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(607687..609228) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /EC_number="1.3.3.5" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="outer spore coat copper-dependent promiscuous laccase" /protein_id="NP_388511.1" /db_xref="EnsemblGenomes-Gn:BSU06300" /db_xref="EnsemblGenomes-Tr:CAB12449" /db_xref="GOA:P07788" /db_xref="InterPro:IPR001117" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011706" /db_xref="InterPro:IPR011707" /db_xref="PDB:1GSK" /db_xref="PDB:1OF0" /db_xref="PDB:1W6L" /db_xref="PDB:1W6W" /db_xref="PDB:1W8E" /db_xref="PDB:2BHF" /db_xref="PDB:2WSD" /db_xref="PDB:2X87" /db_xref="PDB:2X88" /db_xref="PDB:3ZDW" /db_xref="PDB:4A66" /db_xref="PDB:4A67" /db_xref="PDB:4A68" /db_xref="PDB:4AKO" /db_xref="PDB:4AKP" /db_xref="PDB:4AKQ" /db_xref="PDB:4Q89" /db_xref="PDB:4Q8B" /db_xref="PDB:4YVN" /db_xref="PDB:4YVU" /db_xref="SubtiList:BG10490" /db_xref="UniProtKB/Swiss-Prot:P07788" /translation="MTLEKFVDALPIPDTLKPVQQSKEKTYYEVTMEECTHQLHRDLP PTRLWGYNGLFPGPTIEVKRNENVYVKWMNNLPSTHFLPIDHTIHHSDSQHEEPEVKT VVHLHGGVTPDDSDGYPEAWFSKDFEQTGPYFKREVYHYPNQQRGAILWYHDHAMALT RLNVYAGLVGAYIIHDPKEKRLKLPSDEYDVPLLITDRTINEDGSLFYPSAPENPSPS LPNPSIVPAFCGETILVNGKVWPYLEVEPRKYRFRVINASNTRTYNLSLDNGGDFIQI GSDGGLLPRSVKLNSFSLAPAERYDIIIDFTAYEGESIILANSAGCGGDVNPETDANI MQFRVTKPLAQKDESRKPKYLASYPSVQHERIQNIRTLKLAGTQDEYGRPVLLLNNKR WHDPVTETPKVGTTEIWSIINPTRGTHPIHLHLVSFRVLDRRPFDIARYQESGELSYT GPAVPPPPSEKGWKDTIQAHAGEVLRIAATFGPYSGRYVWHCHILEHEDYDMMRPMDI TDPHK*" /label="cotA CDS" gene complement(607687..609228) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /label="cotA gene" downshifts complement(607700) /Source="Nicolas_upshifts" /id="D308" /incds=0 /nref=46 /ntot=93 /MaxReadThrough="2.97674" /MaxDrop="5.60726" /score="22.3755425" /energy="-9.1" /TU="U488" /idTUdmin="U488" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(609259..609278) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-10" upshifts complement(609273) /Source="Nicolas_upshifts" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="upshifts" promotor_-35 complement(609292..609301) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-35" CDS complement(609380..610789) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16547045, 16850406, 8951816, 9677314, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16547045, 16850406, 8951816, 9677314, 24142252; Product type t : transporter" /codon_start=1 /transl_table=11 /product="gamma-aminobutyrate (GABA) permease; proline permease" /protein_id="NP_388512.2" /db_xref="EnsemblGenomes-Gn:BSU06310" /db_xref="EnsemblGenomes-Tr:CAB12450" /db_xref="GOA:P46349" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="InterPro:IPR011265" /db_xref="SubtiList:BG11328" /db_xref="UniProtKB/Swiss-Prot:P46349" /translation="MNQSQSGLKKELKTRHMTMISIAGVIGAGLFVGSGSVIHSTGPG AVVSYALAGLLVIFIMRMLGEMSAVNPTSGSFSQYAHDAIGPWAGFTIGWLYWFFWVI VIAIEAIAGAGIIQYWFHDIPLWLTSLILTIVLTLTNVYSVKSFGEFEYWFSLIKVVT IIAFLIVGFAFIFGFAPGSEPVGFSNLTGKGGFFPEGISSVLLGIVVVIFSFMGTEIV AIAAGETSNPIESVTKATRSVVWRIIVFYVGSIAIVVALLPWNSANILESPFVAVLEH IGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAERNEAPRRFMKLSKKGVPVQA IVAGTFFSYIAVVMNYFSPDTVFLFLVNSSGAIALLVYLVIAVSQLKMRKKLEKTNPE ALKIKMWLFPFLTYLTIIAICGILVSMAFIDSMRDELLLTGVITGIVLISYLVFRKRK VSEKAAANPVTQQQPDILP*" /label="gabP CDS" gene complement(609380..610789) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /label="gabP gene" downshifts complement(609394) /Source="Nicolas_upshifts" /id="D309" /incds=0 /nref=124 /ntot=216 /MaxReadThrough="3.22899" /MaxDrop="5.0359" /score="18.985683" /energy="-13.5" /TU="U489" /idTUdmin="U489" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(610827..611114) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097690.1" /db_xref="EnsemblGenomes-Gn:BSU06319" /db_xref="EnsemblGenomes-Tr:CAX52577" /db_xref="UniProtKB/Swiss-Prot:C0H3X2" /translation="MIHPPQKNSDEGTLFLSSNLFAPPKIPSNPRTPVLLAFYRIVNI TQNHTANKKRNIFSTHSLKAQTKHYKFEISWYIFLHEFSTNCIFMIEFQLS*" /label="ydzX CDS" gene complement(610827..611114) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /label="ydzX gene" misc_feature complement(610830..610849) /Source="Nicolas_upshift_promotors" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(610844) /Source="Nicolas_upshifts" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="upshifts" promotor_-35 611120..611127 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 611143..611162 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 611144 /Source="Nicolas_upshifts" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="upshifts" CDS 611187..612059 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="secondary Mn(II) exporter, promiscuous" /protein_id="NP_388513.1" /db_xref="EnsemblGenomes-Gn:BSU06320" /db_xref="EnsemblGenomes-Tr:CAB12451" /db_xref="GOA:P46348" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11329" /db_xref="UniProtKB/Swiss-Prot:P46348" /translation="MERYDELKKGESGALVSIAAYLVLSAIKLIIGYLFHSEALTADG LNNTTDIIASVAVLIGLRISQKPPDEDHPYGHFRAETIASLIASFIMMVVGLQVLFSA GESIFSAKQETPDMIAAWTAAGGAVLMLIVYRYNKRLAKKVKSQALLAAAADNKSDAF VSIGTFIGIVAAQFHLAWIDTVTAFVIGLLICKTAWDIFKESSHSLTDGFDIKDISAY KQTIEKISGVSRLKDIKARYLGSTVHVDVVVEVSADLNITESHDIANEIERRMKEEHA IDYSHVHMEPLEQK*" /label="mneS CDS" gene 611187..612059 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /label="mneS gene" downshifts 612024 /Source="Nicolas_upshifts" /id="D310" /incds=0 /nref=2 /ntot=88 /MaxReadThrough="1.72291" /MaxDrop="2.86431" /score="24.8167732" /energy="-10.2" /TU="U490" /idTUdmin="U490" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(612299) /Source="Nicolas_upshifts" /id="D311" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="0.65827" /MaxDrop="3.33542" /score="-0.424989042" /energy="-12.9" /TU="NA" /idTUdmin="U489" /TUdmin="-3015" /isTUend="FALSE" /label="downshifts" misc_feature 612353..612372 /Source="Nicolas_upshift_promotors" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 612363 /Source="Nicolas_upshifts" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="upshifts" CDS 612409..613371 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21907250, 26933057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative MoxR-like ATPase" /protein_id="NP_388514.2" /db_xref="EnsemblGenomes-Gn:BSU06330" /db_xref="EnsemblGenomes-Tr:CAB12452" /db_xref="GOA:P94474" /db_xref="InterPro:IPR011703" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12211" /db_xref="UniProtKB/Swiss-Prot:P94474" /translation="MAYQEDLHPLLGKAVEHINRVMVGKRDIAILSLAALLAKGHVLL EDVPGVGKTMMVRALAKSIGADFKRIQFTPDLLPSDVTGVSIYNAKTMEFEYRPGPIM GNIVLADEINRTSPKTQSALLEAMEEGSVTVDGHTMQLADPFFVMATQNPVEYEGTYP LPEAQLDRFLFKLRMGYPSFNEELDVLSLQEKSHPIETLEPVIAKEDFIFLQREVQNV RADDSIKEYIVEIVQKTRQHPSVQLGVSPRGSIALMKAAQAYALLHHRDYVIPDDIQY LAPFTLPHRMMLHPEAKFEGIQAEAIVREIMSAVKVPVQRSAVR*" /label="yeaC CDS" gene 612409..613371 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /label="yeaC gene" CDS 613371..614567 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388515.2" /db_xref="EnsemblGenomes-Gn:BSU06340" /db_xref="EnsemblGenomes-Tr:CAB12453" /db_xref="InterPro:IPR002881" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12212" /db_xref="UniProtKB/Swiss-Prot:P94475" /translation="MNKKWQWLVYGWKLIILTLLTAAVFSYAMFQGGFVSWFLFYAFL PFVLYAGLLALYPLRSFQASRQMDKTQLHAGDRLGVTVTLRRKLPFPLMYMVIEDCLP EGIESLNRDGAAAKRLVFPWFKRSMTMSYELARVPRGEHHFHSVRVRTGDVLGLIEKT AFFELDDTLFVYPFYQRFSYQVNERHQEDGVSGSSPIHQHHSSVAASVRNYQPGDRFA ALDWKTSARRSQLMTKEFEPSRSKNLFLLMDRFSSDAFEEVVSVTASILHSVLKNGAG AGLASIGKEKNIFPIQEGDQHFKHMLRHLAIAHCDAADPISRYAREELGKPSVRQADQ VVVTGQLTEDMLHLAEIGGGRVTVILAKEKDAELSQAENVMIERMMKRQIRVRIMRGG RVSRVV*" /label="yeaD CDS" gene 613371..614567 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /label="yeaD gene" CDS 614589..616802 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388516.2" /db_xref="EnsemblGenomes-Gn:BSU06350" /db_xref="EnsemblGenomes-Tr:CAB12454" /db_xref="GOA:P94476" /db_xref="InterPro:IPR002931" /db_xref="InterPro:IPR025403" /db_xref="InterPro:IPR036985" /db_xref="SubtiList:BG12213" /db_xref="UniProtKB/Swiss-Prot:P94476" /translation="MPHDDHKGSRLSLLLFYFLAFLLLWEWLRPLDSFTETKHTGFFS VFIGLTFLLTFFRMRWFVTVPFCVIFTLISIHILFYQGSIFDLSWVSSFLQDVYLNIT LIQSGQWNDMIPSFRTLLFFVLLWLLVYLLHYWVIYQRRILFFFLMTVAYITILDTFT PYDATFAVIRIVLIGFFMLGLLYLERIKLMERITLPKTSVLKWFLPLSVLVLAATGFG LAAPKSEPAWPDPVPFLKKITHQDRVSAGESKIGYGNHDESLGGPFQQDATPVFTWQG KERTYFRVETKDTYTGKGWIETDTGMSYQLSNGKVENLWFDHKVATERRTVRVKVDKH YGYNHLMYPIGAETIQPKQAVSLEMNGNTEQISPISEQAGEIRNMGNYTVTYNSPVYK LDELRKVKVRKNSEEYTFSDRYMQLPDSLPERVRTLAIKLTQDHDNMFDKVKAVEDYL GSNAFTYETENVTIPKNDEDYVDQFLFETKMGYCDNFSSAMVVLLRSAGIPARWVKGY TSGEYKEAGNKNGSIYEVTNNNAHSWVEVYFPEQGWVTFEPTKGFTNPAQFTSSDTKD SGSDSSSSPKKAKEKQKEEKKQPQKEEKQKEKREPAVSKKPSASHTNAGAGLYAALAV LAVLLVAAVLLYVFRSLWIPVFAVRKLKRRSDQHAFFEAYGALLKQLKRKGLPKRDSE TLRDYAKRIDEKYDIEDMSKLTLSYERALYRNEDSSALWNDSRELWENLIKRRWS*" /label="yebA CDS" gene 614589..616802 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /label="yebA gene" promotor_-35 616797..616804 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 616819..616838 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 616835..616964 /Source="Nicolas_S_feature" /locus_tag="new_692610_692739" /HighExp="G180, Oxctl, G135, LBGexp, G150, Paraq, C30, LPh, MG 25, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63292099999999996" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S227" upshifts 616835 /Source="Nicolas_upshifts" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="upshifts" CDS 616965..618506 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /EC_number="6.3.5.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1312531, 21856856; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP synthetase" /protein_id="NP_388517.2" /db_xref="EnsemblGenomes-Gn:BSU06360" /db_xref="EnsemblGenomes-Tr:CAB12455" /db_xref="GOA:P29727" /db_xref="InterPro:IPR001674" /db_xref="InterPro:IPR004739" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022955" /db_xref="InterPro:IPR025777" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10647" /db_xref="UniProtKB/Swiss-Prot:P29727" /translation="MTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTAEE IKKMNPKGIILSGGPNSVYDENSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEAA SQREYGKANIRIEGTPDLFRDLPNEQVVWMSHGDLVVEVPEGFTVDATSHHCPNSAMS KADKKWYGVQFHPEVRHSEYGNDLLKNFVFGVCECEGEWSMENFIEIEMQKIRETVGD KQVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNV IKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADKLKGIDYLAQGTLYTDIIE SGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDEIVWRQPFP GPGLGIRVLGEVTEEKLEIVRESDAILREEIANHGLERDIWQYFTVLPDIRSVGVMGD ARTYDYTIGIRAVTSIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYDITSKPPA TIEWE*" /label="guaA CDS" gene 616965..618506 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /label="guaA gene" downshifts 618492 /Source="Nicolas_upshifts" /id="D312" /incds=0 /nref=247 /ntot=268 /MaxReadThrough="2.12151" /MaxDrop="7.3702" /score="22.5795134" /energy="-18.5" /TU="NA" /idTUdmin="U492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 618613..618617 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-35" promotor_-10 618633..618652 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-10" upshifts 618643 /Source="Nicolas_upshifts" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="upshifts" misc_RNA 618650..618752 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswC RNA" gene 618650..618752 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /label="gswC gene" downshifts 618778 /Source="Nicolas_upshifts" /id="D313" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="8.01916" /MaxDrop="4.7859" /score="24.3821572" /energy="-11.3" /TU="U493" /idTUdmin="U492" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 618887..620209 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3110131, 11591660, 12923093, 15849754, 16850406, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 11591660, 12923093, 15849754, 16850406, 19446032; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_388518.1" /db_xref="EnsemblGenomes-Gn:BSU06370" /db_xref="EnsemblGenomes-Tr:CAB12456" /db_xref="GOA:O34987" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG12811" /db_xref="UniProtKB/Swiss-Prot:O34987" /translation="MKTFFQFDELGTSYRNEIIGGLTTFLSMAYILFVNPITLALESV KDFPEALRIDQGAVFTATALASAAGCILMGLIARYPIAIAPGMGLNAFFAFSVVLGMG ISWQAALSGVFISGLIFVALSLTGFREKIINAIPPELKLAVGAGIGLFITFVGLQGSG IITANPSTLVTIGNIHSGPVLLTIFGVIVTVILMVLRVNAGVFIGMLLTAVAGMIFGL VPVPTQIIGSVPSLAPTFGQAWIHLPDIFSVQMLIVILTFLFVGFFDTAGTLVAVATQ AGLMKENKLPRAGRALLADSSSIVIGAVLGTSTTTSYVESSSGVAAGARSGFAAIVTG ILFLLATFFSPLLSVVTSNVTAPALIIVGALMVAPLGKIAWDKFEVAVPAFLTMIMMP LTYSIATGIAIGFIFYPITMVCKGKAKEVHPIMYGLFVVFILYFIFLK*" /label="pbuG CDS" gene 618887..620209 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /label="pbuG gene" downshifts 620187 /Source="Nicolas_upshifts" /id="D314" /incds=0 /nref=47 /ntot=153 /MaxReadThrough="4.18958" /MaxDrop="4.86237" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 620230 /Source="Nicolas_upshifts" /id="D315" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="3.09696" /MaxDrop="3.87785" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-43" /isTUend="FALSE" /label="downshifts" promotor_-35 620259..620268 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 620279..620419 /Source="Nicolas_S_feature" /locus_tag="new_696054_696194" /HighExp="T1.30H, T1.0H, T2.0H, T0.30H, B60, T2.30H, T-0.40H, T0.0H, T3.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S228" upshifts 620279 /Source="Nicolas_upshifts" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 620281..620296 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 620420..621223 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388519.2" /db_xref="EnsemblGenomes-Gn:BSU06380" /db_xref="EnsemblGenomes-Tr:CAB12457" /db_xref="GOA:O34341" /db_xref="SubtiList:BG12812" /db_xref="UniProtKB/Swiss-Prot:O34341" /translation="MTEERKETFEEEINQSERIDADEEPLSRMSRKASRQSKQKQKQK QKPRQERGESTVKDKLASVWAAINRYCGFAFSILKSPAKTVVTDGFSHYKYGLISMLI FSIIFSIGNWFQLKASWNRPLGFGERHHAFYDGFLVVLVYLLIFFAVMVFAIWAVSRY MMKQKVTFREAAAVLGSLLVPVIAVSILWLIFAIVNIPMLTVLFTVLILFSIFFIIAL YVQRVYQAAQDAPIDYIYCVFAVVAIALLFTAVTWPFISEYITASLIPL*" /label="yebC CDS" gene 620420..621223 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /label="yebC gene" downshifts 621208 /Source="Nicolas_upshifts" /id="D316" /incds=0 /nref=218 /ntot=263 /MaxReadThrough="1.47691" /MaxDrop="7.03926" /score="33.0377004" /energy="-10.7" /TU="NA" /idTUdmin="U494" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 621291..621298 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 621312..621331 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 621318..621381 /Source="Nicolas_S_feature" /locus_tag="new_697093_697156" /HighExp="B60, S2, S7, S8, Lbstat, nit, S4, BC, BT, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S229" upshifts 621318 /Source="Nicolas_upshifts" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="upshifts" CDS 621382..621549 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388520.3" /db_xref="EnsemblGenomes-Gn:BSU06390" /db_xref="EnsemblGenomes-Tr:CAB12458" /db_xref="InterPro:IPR025072" /db_xref="SubtiList:BG12813" /db_xref="UniProtKB/Swiss-Prot:O34904" /translation="MADVLRRAINQKKQFLKTKLLLSEFYQGRGEQLADYTLSELEKE YKSLQKMKKEI*" /label="yebD CDS" gene 621382..621549 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /label="yebD gene" downshifts 621556 /Source="Nicolas_upshifts" /id="D317" /incds=0 /nref=64 /ntot=163 /MaxReadThrough="2.85884" /MaxDrop="5.66286" /score="29.2645456" /energy="-9" /TU="NA" /idTUdmin="U495" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 621600..621606 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 621621..621639 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 621624..621710 /Source="Nicolas_S_feature" /locus_tag="new_697399_697485" /HighExp="Etha, Gly, M9-stat, Sw, B60, S4, S6, LPhT, S3, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S230" upshifts 621624 /Source="Nicolas_upshifts" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 621689..621696 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 621710..621729 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 621712 /Source="Nicolas_upshifts" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="upshifts" CDS 621763..622317 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388521.2" /db_xref="EnsemblGenomes-Gn:BSU06400" /db_xref="EnsemblGenomes-Tr:CAB12459" /db_xref="GOA:O34624" /db_xref="InterPro:IPR019264" /db_xref="InterPro:IPR022930" /db_xref="SubtiList:BG12814" /db_xref="UniProtKB/Swiss-Prot:O34624" /translation="MMQTILSNGIAMVLIILIINIVYVSFFTIRMILTLKGQRYLAAG ISTIEILVYVTGLSLVLDNLDQIQNVIAYALGYGLGVIVGMKIEEKLALGYIMVNVIT KELDLDLPKQLREKGYGVTNWVAGGLEGDRTALQILTPRRYELQLYDTIKTLDSKAFI IAYEPKTIHGGFWVKAVKKRRIKE*" /label="yebE CDS" gene 621763..622317 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /label="yebE gene" CDS 622317..622514 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388523.1" /db_xref="EnsemblGenomes-Gn:BSU06410" /db_xref="EnsemblGenomes-Tr:CAB12461" /db_xref="InterPro:IPR025930" /db_xref="SubtiList:BG12816" /db_xref="UniProtKB/Swiss-Prot:O34700" /translation="MAKPKKKKFEVTEQQTIDAVLQQMKEEGYLPVRRMEEPIFMEKK ENGSIQIVPCGKKIVFEGKLI*" /label="yebG CDS" gene 622317..622514 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /label="yebG gene" downshifts 622504 /Source="Nicolas_upshifts" /id="D318" /incds=0 /nref=2 /ntot=91 /MaxReadThrough="2.80904" /MaxDrop="2.65424" /score="17.462689" /energy="-17.6" /TU="U496" /idTUdmin="U497" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 622560..622567 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 622582..622601 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 622584 /Source="Nicolas_upshifts" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 622594..622696 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswD RNA" gene 622594..622696 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /label="gswD gene" S_feature 622697..622836 /Source="Nicolas_S_feature" /locus_tag="new_698472_698611" /HighExp="MG 10, MG 15, MG t5, BMM, MG 25, MG 5, HPh, GM 45, GM 90, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S231" CDS 622837..623325 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /EC_number="5.4.99.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12787499, 16138311, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide mutase" /protein_id="NP_388524.1" /db_xref="EnsemblGenomes-Gn:BSU06420" /db_xref="EnsemblGenomes-Tr:CAB12462" /db_xref="GOA:P12044" /db_xref="InterPro:IPR000031" /db_xref="InterPro:IPR024694" /db_xref="InterPro:IPR033747" /db_xref="InterPro:IPR035893" /db_xref="SubtiList:BG10700" /db_xref="UniProtKB/Swiss-Prot:P12044" /translation="MQPLVGIIMGSTSDWETMKHACDILDELNVPYEKKVVSAHRTPD FMFEYAETARERGIKVIIAGAGGAAHLPGMTAAKTTLPVIGVPVQSKALNGMDSLLSI VQMPGGVPVATTSIGKAGAVNAGLLAAQILSAFDEDLARKLDERRENTKQTVLESSDQ LV*" /label="purE CDS" gene 622837..623325 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /label="purE gene" CDS 623318..624460 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /EC_number="6.3.4.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8998996, 9683488, 21931218, 25372694; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide synthase" /protein_id="NP_388525.2" /db_xref="EnsemblGenomes-Gn:BSU06430" /db_xref="EnsemblGenomes-Tr:CAB12463" /db_xref="GOA:P12045" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005875" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10701" /db_xref="UniProtKB/Swiss-Prot:P12045" /translation="MSKQIIYPGAVIGIIGGGQLGKMMAVSAKQMGYKVAVVDPVKDS PCGQVADVEITAHYNDREAIRKLAEISDIITYEFENIDYDALHWLKDHAYLPQGSELL LITQNRETEKKAIQSAGCEVAPYSIVKTKNELKQAVQELRLPAVLKTCRGGYDGKGQF VIKEEAQMEQAAALLEHGTCILESWVSFKMELSVIVVRSVNGEISTFPTAENIHHNNI LFQSIVPARVEKGIQQKAADLAVKLADELNLVGPLAVEMFLTEDGELLVNELAPRPHN SGHYTLDLCETSQFEQHIRAVCGLPLGKTDLLKPGMMVNLLGDEVKLVEEDPELLKEA KLYIYGKHEIKKGRKMGHITFMKQPEDEWIQEITNKWMNRDGGQAE*" /label="purK CDS" gene 623318..624460 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /label="purK gene" CDS 624457..625752 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /EC_number="4.3.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9622500, 9683488, 9890879, 11063569, 12787499; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate lyase" /protein_id="NP_388526.1" /db_xref="EnsemblGenomes-Gn:BSU06440" /db_xref="EnsemblGenomes-Tr:CAB12464" /db_xref="GOA:P12047" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004769" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR019468" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="PDB:1F1O" /db_xref="SubtiList:BG10702" /db_xref="UniProtKB/Swiss-Prot:P12047" /translation="MIERYSRPEMSAIWTDENRFQAWLEVEILACEAWAELGVIPKED VKVMRENASFDINRILEIEKDTRHDVVAFTRAVSESLGEERKWVHYGLTSTDVVDTAL SYLLKQANDILLKDLERFVDIIKEKAKEHKYTVMMGRTHGVHAEPTTFGLKLALWHEE MKRNLERFKQAKAGIEVGKISGAVGTYANIDPFVEQYVCEKLGLKAAPISTQTLQRDR HADYMATLALIATSIEKFAVEIRGLQKSETREVEEFFAKGQKGSSAMPHKRNPIGSEN MTGMARVIRGYMMTAYENVPLWHERDISHSSAERIILPDATIALNYMLNRFSNIVKNL TVFPENMKRNMDRTLGLIYSQRVLLALIDTGLTREEAYDTVQPKAMEAWEKQVPFREL VEAEEKITSRLSPEKIADCFDYNYHLKNVDLIFERLGLA*" /label="purB CDS" gene 624457..625752 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /label="purB gene" promotor_-10 complement(624762..624781) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(624783) /Source="Nicolas_upshifts" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(624796..624803) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 625826..626551 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /EC_number="6.3.2.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2495272, 9683488, 10784038, 12787499, 26118696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole succinocarboxamide synthetase" /protein_id="NP_388527.1" /db_xref="EnsemblGenomes-Gn:BSU06450" /db_xref="EnsemblGenomes-Tr:CAB12465" /db_xref="GOA:P12046" /db_xref="InterPro:IPR001636" /db_xref="InterPro:IPR018236" /db_xref="InterPro:IPR028923" /db_xref="InterPro:IPR033934" /db_xref="SubtiList:BG10703" /db_xref="UniProtKB/Swiss-Prot:P12046" /translation="MNIVKNELLYEGKAKKIYKTDDENTLYVVYKDSATAFNGEKKAE ISGKGRLNNEISSLIFKHLHAKGINNHFIERISETEQLIKKVTIVPLEVVVRNVVAGS MSKRLGIPEGTELEQPIIEFYYKDDALGDPLITEDHIWLLKAATPEQVETIKSITTIV NEELQSIFDDCHVRLIDFKLEFGLDAEGQVLLADEISPDTCRLWDKETNEKLDKDLFR RNLGSLTDAYEEIFNRLGGIHHV*" /label="purC CDS" gene 625826..626551 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /label="purC gene" CDS 626544..626798 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10784038, 12787499" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10784038, 12787499; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for phosphoribosylformylglycinamidine synthetase activity" /protein_id="NP_388528.1" /db_xref="EnsemblGenomes-Gn:BSU06460" /db_xref="EnsemblGenomes-Tr:CAB12466" /db_xref="GOA:P12049" /db_xref="InterPro:IPR003850" /db_xref="InterPro:IPR036604" /db_xref="PDB:1T4A" /db_xref="PDB:1TWJ" /db_xref="SubtiList:BG10704" /db_xref="UniProtKB/Swiss-Prot:P12049" /translation="MYKVKVYVSLKESVLDPQGSAVQHALHSMTYNEVQDVRIGKYME LTIEKSDRDLDVLVKEMCEKLLANTVIEDYRYEVEEVVAQ*" /label="purS CDS" gene 626544..626798 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /label="purS gene" CDS 626795..627478 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301530, 15301532, 10784038, 9683488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301530, 15301532, 10784038, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit I" /protein_id="NP_388529.1" /db_xref="EnsemblGenomes-Gn:BSU06470" /db_xref="EnsemblGenomes-Tr:CAB12467" /db_xref="GOA:P12041" /db_xref="InterPro:IPR010075" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10706" /db_xref="UniProtKB/Swiss-Prot:P12041" /translation="MKFAVIVLPGSNCDIDMYHAVKDELGHEVEYVWHEETSLDGFDG VLIPGGFSYGDYLRCGAIARFANIMPAVKQAAAEGKPVLGVCNGFQILQELGLLPGAM RRNKDLKFICRPVELIVQNDETLFTASYEKGESITIPVAHGEGNFYCDDETLATLKEN NQIAFTYGSNINGSVSDIAGVVNEKGNVLGMMPHPERAVDELLGSADGLKLFQSIVKN WRETHVTTA*" /label="purQ CDS" gene 626795..627478 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /label="purQ gene" CDS 627462..629690 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301532, 10784038, 9683488, 21671997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301532, 10784038, 9683488, 21671997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit II" /protein_id="NP_388530.2" /db_xref="EnsemblGenomes-Gn:BSU06480" /db_xref="EnsemblGenomes-Tr:CAB12468" /db_xref="GOA:P12042" /db_xref="InterPro:IPR010074" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10705" /db_xref="UniProtKB/Swiss-Prot:P12042" /translation="MSLLLEPSKEQIKEEKLYQQMGVSDDEFALIESILGRLPNYTEI GIFSVMWSEHCSYKNSKPILRKFPTSGERVLQGPGEGAGIVDIGDNQAVVFKIESHNH PSALEPYQGAATGVGGIIRDVFSMGARPIAVLNSLRFGELTSPRVKYLFEEVVAGIAG YGNCIGIPTVGGEVQFDSSYEGNPLVNAMCVGLINHEDIKKGQAKGVGNTVMYVGAKT GRDGIHGATFASEEMSDSSEEKRSAVQVGDPFMEKLLLEACLEVIQCDALVGIQDMGA AGLTSSSAEMASKAGSGIEMNLDLIPQRETGMTAYEMMLSESQERMLLVIERGREQEI IDIFDKYDLEAVSVGHVTDDKMLRLTHKGEVVCELPVDALAEEAPVYHKPSQEPAYYR EFLETDVPAPQIEDANEMLKALLQQPTIASKEWVYDQYDYMVRTNTVVAPGSDAGVLR IRGTKKALAMTTDCNARYLYLDPEVGGKIAVAEAARNIICSGAEPLAVTDNLNFGNPE KPEIFWQIEKAADGISEACNVLSTPVIGGNVSLYNESNGTAIYPTPVIGMVGLIEDTA HITTQHFKQAGDLVYVIGETKPEFAGSELQKMTEGRIYGKAPQIDLDVELSRQKALLD AIKKGFVQSAHDVSEGGLGVAIAESVMTTENLGANVTVEGEAALLFSESQSRFVVSVK KEHQAAFEATVKDAVHIGEVTADGILAIQNQDGQQMIHAQTKELERVWKGAIPCLLKS KA*" /label="purL CDS" gene 627462..629690 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /label="purL gene" downshifts complement(627710) /Source="Nicolas_upshifts" /id="D319" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="0.69202" /MaxDrop="3.99287" /score="-6.56256716" /energy="-16.7" /TU="NA" /idTUdmin="U499" /TUdmin="-3147" /isTUend="FALSE" /label="downshifts" CDS 629666..631096 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /EC_number="2.4.2.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 10049369, 12787499, 16321950, 17981983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 10049369, 12787499, 16321950, 17981983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine phosphoribosylpyrophosphate amidotransferase" /protein_id="NP_388531.2" /db_xref="EnsemblGenomes-Gn:BSU06490" /db_xref="EnsemblGenomes-Tr:CAB12469" /db_xref="GOA:P00497" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005854" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR035584" /db_xref="PDB:1AO0" /db_xref="PDB:1GPH" /db_xref="SubtiList:BG10707" /db_xref="UniProtKB/Swiss-Prot:P00497" /translation="MLAEIKGLNEECGVFGIWGHEEAPQITYYGLHSLQHRGQEGAGI VATDGEKLTAHKGQGLITEVFQNGELSKVKGKGAIGHVRYATAGGGGYENVQPLLFRS QNNGSLALAHNGNLVNATQLKQQLENQGSIFQTSSDTEVLAHLIKRSGHFTLKDQIKN SLSMLKGAYAFLIMTETEMIVALDPNGLRPLSIGMMGDAYVVASETCAFDVVGATYLR EVEPGEMLIINDEGMKSERFSMNINRSICSMEYIYFSRPDSNIDGINVHSARKNLGKM LAQESAVEADVVTGVPDSSISAAIGYAEATGIPYELGLIKNRYVGRTFIQPSQALREQ GVRMKLSAVRGVVEGKRVVMVDDSIVRGTTSRRIVTMLREAGATEVHVKISSPPIAHP CFYGIDTSTHEELIASSHSVEEIRQEIGADTLSFLSVEGLLKGIGRKYDDSNCGQCLA CFTGKYPTEIYQDTVLPHVKEAVLTK*" /label="purF CDS" gene 629666..631096 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /label="purF gene" S_feature 631097..631197 /Source="Nicolas_S_feature" /locus_tag="new_706872_706972" /HighExp="MG 15, MG 25, MG 10, MG 5, aero, S0, MG t5, Gly, LPh, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S232" CDS 631198..632238 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /EC_number="6.3.3.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10508786, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole synthetase" /protein_id="NP_388532.2" /db_xref="EnsemblGenomes-Gn:BSU06500" /db_xref="EnsemblGenomes-Tr:CAB12470" /db_xref="GOA:P12043" /db_xref="InterPro:IPR004733" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10708" /db_xref="UniProtKB/Swiss-Prot:P12043" /translation="MSEAYKNAGVDIEAGYEAVKRMKKHVERTKRLGVMGSLGGFGGM FDLSELSYQKPVLISGTDGVGTKLKLAFSMDKHDTIGVDAVAMCVNDVLAQGAEPLFF LDYLAVGKADPVKIEQIVQGVAEGCEQSGSALVGGETAEMPGLYTADEYDIAGFSVGV AEKDEIVTGEKIEEGHLLIGLSSSGLHSNGFSLVRKVLLDDAELDLDTTYEPFERPLG EELLEPTRIYVKPVLAAVKSGKIDGMAHVTGGGFIENIPRMLPEGLSAEIDHGSWPIP PIFSFLQEYGKLKEEDMFNVFNMGIGFVLAVKEEHLTDVIGTLESHGEKAYLIGRVKK GEGVTFGGAALS*" /label="purM CDS" gene 631198..632238 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /label="purM gene" CDS 632235..632822 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /EC_number="2.1.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10569930, 12787499, 19574646; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase" /protein_id="NP_388533.2" /db_xref="EnsemblGenomes-Gn:BSU06510" /db_xref="EnsemblGenomes-Tr:CAB12471" /db_xref="GOA:P12040" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR004607" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG10709" /db_xref="UniProtKB/Swiss-Prot:P12040" /translation="MKKFAVFASGNGSNFEAIVTRLKEENWDASAALLVCDKPQAKVI ERAEAFHIPSFAFEPKSYENKAAFEQAIIEQLRLHEVELIALAGYMRLIGDTLLQAYG GKIINIHPSLLPAFPGIDAVGQAFRAGVKVAGITVHYVDEGMDTGPIIAQKAIEIDEH DTLETIEQRIHKLEHKWYPSVIKQLLGLNNRGEKA*" /label="purN CDS" gene 632235..632822 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /label="purN gene" misc_feature 632245..632259 /Source="Nicolas_upshift_promotors" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 632254 /Source="Nicolas_upshifts" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(632521..632539) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(632528) /Source="Nicolas_upshifts" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(632555..632560) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 632819..634357 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /EC_number="2.1.2.3" /EC_number="3.5.4.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787499, 1937050, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused phosphoribosylaminoimidazole carboxy formyl formyltransferase; inosine-monophosphate cyclohydrolase" /protein_id="NP_388534.2" /db_xref="EnsemblGenomes-Gn:BSU06520" /db_xref="EnsemblGenomes-Tr:CAB12472" /db_xref="GOA:P12048" /db_xref="InterPro:IPR002695" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024051" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10710" /db_xref="UniProtKB/Swiss-Prot:P12048" /translation="MTIKRALISVSDKTNLVPFVKELTELGVEVISTGGTKKLLQENG VDVIGISEVTGFPEIMDGRLKTLHPNIHGGLLAVRGNEEHMAQINEHGIQPIDLVVVN LYPFKETISKEDVTYEEAIENIDIGGPGMLRAASKNHQDVTVIVDPADYSPVLNQIKE EGSVSLQKKRELAAKVFRHTAAYDALIADYLTNVVGEKEPEQFTVTFEKKQSLRYGEN PHQEATFYQTALPVKGSIAQAEQLHGKELSYNNIKDADAAVQIVREFTEPAAVAVKHM NPCGVGTGKTIAEAFDRAFEADKTSIFGGIIALNREVDKATAEALHNIFLEIIIAPSF SQEALDVLTAKKNLRLLTLDVSAAVQKEKQLTSVQGGLLIQDLDMHGFDDAEISIPTK REPNEQEWEDLKLAWKVVKHVKSNAIVLAKDNMTVGVGAGQMNRVGSAKIAIEQAGEK AKGSALGSDAYFPMPDTVEEAAKAGVTAIIQPGGSIRDEDSIKKADEYGIAMVFTGIR HFKH*" /label="purH CDS" gene 632819..634357 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /label="purH gene" CDS 634373..635641 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /EC_number="6.3.4.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 12787499, 16321950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide synthetase" /protein_id="NP_388535.1" /db_xref="EnsemblGenomes-Gn:BSU06530" /db_xref="EnsemblGenomes-Tr:CAB12473" /db_xref="GOA:P12039" /db_xref="InterPro:IPR000115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR020559" /db_xref="InterPro:IPR020560" /db_xref="InterPro:IPR020561" /db_xref="InterPro:IPR020562" /db_xref="InterPro:IPR037123" /db_xref="PDB:2XCL" /db_xref="PDB:2XD4" /db_xref="SubtiList:BG10711" /db_xref="UniProtKB/Swiss-Prot:P12039" /translation="MNVLIIGKGGREHTLAWKAAQSSLVENVFAAPGNDGMAASAQLV NIEESDHAGLVSFAKQNQVGLTIVGPEVPLIEGLVDEFEKAGLHVFGPSKAAAIIEGS KQFAKDLMKKYDIPTAEYETFTSFDEAKAYVQEKGAPIVIKADGLAAGKGVTVAMTEE EAIACLHDFLEDEKFGDASASVVIEEYLSGEEFSLMAFVKGEKVYPMVIAQDHKRAFD GDKGPNTGGMGAYSPVPQISEETVRHAVETIVKPAAKAMVQEGRSFTGVLYAGLMLTE NGSKVIEFNARFGDPETQVVLPRMESDLVQVLLDLLDDKEVDLRWKDTAAVSVVLASE GYPESYAKGTPIGSLAAETEQVVVFHAGTKAEGGEFVTNGGRVANVTAFDETFEAARD RVYKAVDEIFKPGLFFRKDIGARALKAAQK*" /label="purD CDS" gene 634373..635641 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /label="purD gene" downshifts 635626 /Source="Nicolas_upshifts" /id="D320" /incds=0 /nref=140 /ntot=249 /MaxReadThrough="2.77191" /MaxDrop="5.90939" /score="30.0999687" /energy="-11.4" /TU="NA" /idTUdmin="U500" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(635681..636100) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388536.2" /db_xref="EnsemblGenomes-Gn:BSU06540" /db_xref="EnsemblGenomes-Tr:CAB12474" /db_xref="GOA:O31497" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12874" /db_xref="UniProtKB/Swiss-Prot:O31497" /translation="MDDTDLQILSHLQRNGRLTMVELGKLVGLSSPSAAERVRKLEDK GVITGYSANICYEKLNKHVTAFILMEPKSCKHYAAFATSHPDVAENHRITGMYSYVTK VVTESVHTLEDFIDTSMAHGKPTTLVVLSSSSCHPAF*" /label="yezC CDS" gene complement(635681..636100) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /label="yezC gene" misc_feature complement(636170..636189) /Source="Nicolas_upshift_promotors" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(636179) /Source="Nicolas_upshifts" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="upshifts" CDS 636244..637518 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26319875, 27723097, 24678831; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_388537.2" /db_xref="EnsemblGenomes-Gn:BSU06550" /db_xref="EnsemblGenomes-Tr:CAB12475" /db_xref="GOA:O34560" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12817" /db_xref="UniProtKB/Swiss-Prot:O34560" /translation="MLPELQRSITWIQGTALTIGAVLGCGILILPSVTADTAGPASLF VWVFMSFLSFFLVGTLARLVKIAPSAGGITAYVQLAFQKKAGAILGWIMLGSVPIGVP IIALTGAHYVSYITEAADWQITLIAGCMLAISILLHMRGIQLSANISTLVICVIVFLL VTSIAVSLPHVTIAEFKPFLPHGWSAAGSVSVMIFFSFVGWEMITPLAEEFHRPEKDV PLSLFLAASCVAGLYIMLSFVTVGTHSYGENGEIASLAMLISKGAGESGVYVTVCLAL FITFATIHANIAGFSRMVYALAREGHIPVFFGKLSATKRTPIRVLTAMAAVFGLVLAA HGLFQIDLTTLLKGPSAAFIASYICTMAAALKLLGRRDIGWWMALGAFVACAVIYSFS GWALLYPAVLAAAGYFYMKTKGGHKKKLDHVL*" /label="yecA CDS" gene 636244..637518 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /label="yecA gene" downshifts 637467 /Source="Nicolas_upshifts" /id="D321" /incds=0 /nref=4 /ntot=64 /MaxReadThrough="0.796809999999999" /MaxDrop="2.92696" /score="1.68718502" /energy="-14.2" /TU="NA" /idTUdmin="U498" /TUdmin=1825 /isTUend="FALSE" /label="downshifts" CDS complement(637533..637760) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097691.1" /db_xref="EnsemblGenomes-Gn:BSU06559" /db_xref="EnsemblGenomes-Tr:CAX52578" /db_xref="GOA:C0H3X3" /db_xref="InterPro:IPR021309" /db_xref="UniProtKB/Swiss-Prot:C0H3X3" /translation="MKPNISLINAVFRIACGLTIMSAASAKFTKKPWCRMHLFYIFMG AMKAGSGILRFCPVTYMFQHSDSGNNEHQNG*" /label="yezF CDS" gene complement(637533..637760) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /label="yezF gene" downshifts complement(637544) /Source="Nicolas_upshifts" /id="D322" /incds=0 /nref=29 /ntot=46 /MaxReadThrough="0.14199" /MaxDrop="6.82335" /score="34.1397958" /energy="-13.9" /TU="NA" /idTUdmin="U504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(637761..638181) /Source="Nicolas_S_feature" /locus_tag="new_713536_713956_c" /HighExp="S8, S7, S5, S6, S4, ferm, nit, BT, Pyr, T5.0H" /AntisenseName="yerA" /AntisenseCor="0.38264258041500998" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S233" promotor_-35 637828..637833 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 637844 /Source="Nicolas_upshifts" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 637847..637866 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 637889..639631 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23109554; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenine deaminase YerA" /protein_id="NP_388538.1" /db_xref="EnsemblGenomes-Gn:BSU06560" /db_xref="EnsemblGenomes-Tr:CAB12476" /db_xref="GOA:O34909" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG12829" /db_xref="UniProtKB/Swiss-Prot:O34909" /translation="MSERTFNWKNKDIRAQVDVVDSKLLPTLLLRNALVLNPYVKQWL KKNIWIYQDRIVYVGHELPNRAEEIHTIDCEGKYIVPGYIEPHAHPFQIYNPQTLAEY VSQYGTTTFVNDNLFLLLQSGKKKALTILNELKKQPVQYFWWSRYDLQTEVLNEDHVL PFDVRKQWIEHPDVIQGGEMTGWPRLVDGDDLMLHCMQATKKQRKRIEGHFPGASDKT LTKMKLFGADCDHEAMTGDEVMRRLELGYYVSLRNSSIRPDVRKILQELHEKGFRYYD HFFYTTDGATPNFYKGGMTNELIRIALEEGVPAIDAYNMASFNIAKYYQMDDYLGVVG PGRLASLNILEDPLNPNPVTVLSKGTILRENGCDLKAFTKTDWHKGGLVPLELSYDMT MDDLQFSMPMGVKMRNAVIMEPYMIEIDNSMEQLSFDHDESYLTMLDRHGKWRVNTMI KGFASSVQGFVSSFTTTGDIVAIGKNKADMLLAFARMKEIGGGIVLAENGNILHEIPL ALCGCASSEAYEDVLEKEQKLRDLLTERGYEFCDPIYTLLFLQSTHLPYIRITPRGIF DVMKKTVLFPSIMR*" /label="yerA CDS" gene 637889..639631 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /label="yerA gene" promotor_-10 complement(638166..638177) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(638181) /Source="Nicolas_upshifts" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(638191..638197) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 638212 /Source="Nicolas_upshifts" /id="D323" /incds=1 /nref=13 /ntot=109 /MaxReadThrough="7.92321" /MaxDrop="3.44855" /score="1.68718502" /energy="-14.2" /TU="U503" /idTUdmin="U498" /TUdmin=2570 /isTUend="FALSE" /label="downshifts" promotor_-35 639605..639611 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 639623 /Source="Nicolas_upshifts" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 639624..639643 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 639658..640653 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12073041; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388539.1" /db_xref="EnsemblGenomes-Gn:BSU06570" /db_xref="EnsemblGenomes-Tr:CAB12477" /db_xref="GOA:O34968" /db_xref="InterPro:IPR021416" /db_xref="InterPro:IPR023158" /db_xref="InterPro:IPR035328" /db_xref="PDB:2PSB" /db_xref="SubtiList:BG12830" /db_xref="UniProtKB/Swiss-Prot:O34968" /translation="MKKWMTVCALCFVFFLLVSCQQKDAVPDTAKKLKAPLTGLKTEQ KVTERRPVAVVVNNHPKARPQSGLSKADIVIEALAEGQITRFLAIFQSQMPETVGPVR SAREYFVTLSNGFDSIFVHHGWSPGAKKQLESGAADYMNGLDFDGSLFWRADFSKPPH NSYTSYDYIKKAAEQKGYKLKQETNPLLFQTSDAKPANESYNVRVDYGTNNVTNLVEY NYDKKAEFYTRSSDGVITTDRETGKPVAMQNIFIVEASHHIIDQDGRRDIDLESGGKG LLFQHGNVIETDWKQVNGRIVPVKDGKWLPFVPGKTWINIVPDLDAASISKGEGV*" /label="yerB CDS" gene 639658..640653 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /label="yerB gene" CDS 640656..640970 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor-histidine operons" /protein_id="NP_388540.1" /db_xref="EnsemblGenomes-Gn:BSU06580" /db_xref="EnsemblGenomes-Tr:CAB12478" /db_xref="GOA:Q7BVT7" /db_xref="InterPro:IPR000831" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013368" /db_xref="SubtiList:BG12831" /db_xref="UniProtKB/Swiss-Prot:Q7BVT7" /translation="MQIDKLRGKELDQLFNSILSLKDLEECYRFFDDLCTINEIQSLA QRLEVARMLREGNTYHKIETETGASTATISRVKRCLNYGNDAYEMALDRVKETETESS SK*" /label="yerC CDS" gene 640656..640970 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /label="yerC gene" downshifts 640833 /Source="Nicolas_upshifts" /id="D324" /incds=1 /nref=1 /ntot=25 /MaxReadThrough="7.1005" /MaxDrop="2.3494" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" downshifts 640975 /Source="Nicolas_upshifts" /id="D325" /incds=0 /nref=78 /ntot=262 /MaxReadThrough="3.58776" /MaxDrop="5.59364" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-232" /isTUend="FALSE" /label="downshifts" CDS complement(641005..642582) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /EC_number="1.4.1.13" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15805528, 17114254, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative osmotic shock glutamate synthase subunit (flavoprotein subunit, ferredoxin-dependent)" /protein_id="NP_388541.1" /db_xref="EnsemblGenomes-Gn:BSU06590" /db_xref="EnsemblGenomes-Tr:CAB12479" /db_xref="GOA:O34849" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024188" /db_xref="InterPro:IPR027283" /db_xref="SubtiList:BG12832" /db_xref="UniProtKB/Swiss-Prot:O34849" /translation="METIIIALIAFIIGIIAIPIVLFAWIYIKDEKQQEHSILRNYPV IGRFRYILEKIGPELRQYLYSNDNEEQPFSRKEYEQTVISGKYKSRMMGFGSVRDFDK PGYYIRNAMFPKQREEMHVNQTPKIETQIYKMDADNLFKRKEHAEHIKADPYFLHPDD VQVIGEHTCEKPFYVKGLVGQSAMSYGSLGERAVTALSKGLHLAGGTWMNTGEGGLSE YHLKGGADIICQIGPGLFGVRKRNGEFSWEEFKRKSRIDQIKAFELKLAQGAKTRGGH VDGAKVSEEVADIRNVEPGKSIDSPNRFYEFSNPPEMLDFIEKLRDVGQKPVGIKLVA GHPEELHELFSHMQKSGKHPDFITIDGSEGGTGASFYELADTVGLPIMTALPIVDTLL KQYGLRSQLKIFASGKLLTPDKIAVALALGADFVNIARGMMFSVGCIRALVCHTNTCP AGVATTDPKLQKALSVEEKQHRVCNYVISLREGLFNLAAAAGINSPIHFSKEHVVYRK EDGSIINIDNLIHQFVS*" /label="yerD CDS" gene complement(641005..642582) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /label="yerD gene" downshifts complement(641019) /Source="Nicolas_upshifts" /id="D326" /incds=0 /nref=7 /ntot=24 /MaxReadThrough="2.99325" /MaxDrop="5.6389" /score="34.8793815" /energy="-15.8" /TU="U506" /idTUdmin="U506" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(642596..642615) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(642615) /Source="Nicolas_upshifts" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(642630..642636) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 642779..642782 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 642796 /Source="Nicolas_upshifts" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 642799..642818 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 642847..643533 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16377641, 21761520, 21214173, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16377641, 21761520, 21214173, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heptaprenylglyceryl-phosphate synthase" /protein_id="NP_388542.1" /db_xref="EnsemblGenomes-Gn:BSU06600" /db_xref="EnsemblGenomes-Tr:CAB12480" /db_xref="GOA:O34790" /db_xref="InterPro:IPR008205" /db_xref="PDB:1VIZ" /db_xref="PDB:3VZX" /db_xref="PDB:3VZY" /db_xref="PDB:3VZZ" /db_xref="PDB:3W00" /db_xref="SubtiList:BG12833" /db_xref="UniProtKB/Swiss-Prot:O34790" /translation="MYDVTEWKHVFKLDPNKDLPDEQLEILCESGTDAVIIGGSDGVT EDNVLRMMSKVRRFLVPCVLEVSAIEAIVPGFDLYFIPSVLNSKNADWIVGMHQKAMK EYGELMSMEEIVAEGYCIANPDCKAAALTEADADLNMDDIVAYARVSELLQLPIFYLE YSGVLGDIEAVKKTKAVLETSTLFYGGGIKDAETAKQYAEHADVIVVGNAVYEDFDRA LKTVAAVKGE*" /label="pcrB CDS" gene 642847..643533 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /label="pcrB gene" CDS 643595..645814 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 12682299, 14594837, 16267290, 26070154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_388543.1" /db_xref="EnsemblGenomes-Gn:BSU06610" /db_xref="EnsemblGenomes-Tr:CAB12481" /db_xref="GOA:O34580" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR005751" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG12834" /db_xref="UniProtKB/Swiss-Prot:O34580" /translation="MNYISNQLLSGLNPVQQEAVKTTDGPLLLMAGAGSGKTRVLTHR IAYLMAEKHVAPWNILAITFTNKAAREMKERVESILGPGADDIWISTFHSMCVRILRR DIDRIGINRNFSILDTADQLSVIKGILKERNLDPKKFDPRSILGTISSAKNELTEPEE FSKVAGGYYDQVVSDVYADYQKKLLKNQSLDFDDLIMTTIKLFDRVPEVLEFYQRKFQ YIHVDEYQDTNRAQYMLVKQLAERFQNLCVVGDSDQSIYRWRGADITNILSFEKDYPN ASVILLEQNYRSTKRILRAANEVIKNNSNRKPKNLWTENDEGIKISYYRGDNEFGEGQ FVAGKIHQLHSTGKRKLSDIAILYRTNAQSRVIEETLLKAGLNYNIVGGTKFYDRKEI KDILAYLRLVSNPDDDISFTRIVNVPKRGVGATSLEKIASYAAINGLSFFQAIQQVDF IGVSAKAANALDSFRQMIENLTNMQDYLSITELTEEILDKTEYREMLKAEKSIEAQSR LENIDEFLSVTKNFEQKSEDKTLVAFLTDLALIADIDQLDQKEEESGGKDAITLMTLH AAKGLEFPVVFLMGLEEGVFPHSRSLMEEAEMEEERRLAYVGITRAEQELYLTNAKMR TLFGRTNMNPESRFIAEIPDDLLENLNEKKETRATSARKMQPRRGPVSRPVSYASKTG GDTLNWAVGDKAGHKKWGTGTVVSVKGEGEGTELDIAFPSPVGVKRLLAAFAPIEKQ* " /label="pcrA CDS" gene 643595..645814 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /label="pcrA gene" CDS 645838..647844 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /EC_number="6.5.1.2" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:164915, 11095673, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 164915, 11095673, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ligase (NAD-dependent)" /protein_id="NP_388544.1" /db_xref="EnsemblGenomes-Gn:BSU06620" /db_xref="EnsemblGenomes-Tr:CAB12482" /db_xref="GOA:O31498" /db_xref="InterPro:IPR001357" /db_xref="InterPro:IPR001679" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004149" /db_xref="InterPro:IPR004150" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013839" /db_xref="InterPro:IPR013840" /db_xref="InterPro:IPR018239" /db_xref="InterPro:IPR033136" /db_xref="InterPro:IPR036420" /db_xref="SubtiList:BG12835" /db_xref="UniProtKB/Swiss-Prot:O31498" /translation="MDKETAKQRAEELRRTINKYSYEYYTLDEPSVPDAEYDRLMQEL IAIEEEHPDLRTPDSPTQRVGGAVLEAFQKVTHGTPMLSLGNAFNADDLRDFDRRVRQ SVGDDVAYNVELKIDGLAVSLRYEDGYFVRGATRGDGTTGEDITENLKTIRNIPLKMN RELSIEVRGEAYMPKRSFEALNEERIKNEEEPFANPRNAAAGSLRQLDPKIAAKRNLD IFVYSIAELDEMGVETQSQGLDFLDELGFKTNQERKKCGSIEEVITLIDELQAKRADL PYEIDGIVIKVDSLDQQEELGFTAKSPRWAIAYKFPAEEVVTKLLDIELNVGRTGVIT PTAILEPVKVAGTTVSRASLHNEDLIKEKDIRILDKVVVKKAGDIIPEVVNVLVDQRT GEEKEFSMPTECPECGSELVRIEGEVALRCINPECPAQIREGLIHFVSRNAMNIDGLG ERVITQLFEENLVRNVADLYKLTKERVIQLERMGEKSTENLISSIQKSKENSLERLLF GLGIRFIGSKAAKTLAMHFESLENLKKASKEELLAVDEIGEKMADAVITYFHKEEMLE LLNELQELGVNTLYKGPKKVKAEDSDSYFAGKTIVLTGKLEELSRNEAKAQIEALGGK LTGSVSKNTDLVIAGEAAGSKLTKAQELNIEVWNEEQLMGELKK*" /label="ligA CDS" gene 645838..647844 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /label="ligA gene" CDS 647860..649050 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388545.1" /db_xref="EnsemblGenomes-Gn:BSU06630" /db_xref="EnsemblGenomes-Tr:CAB12483" /db_xref="GOA:O34629" /db_xref="InterPro:IPR011426" /db_xref="SubtiList:BG12836" /db_xref="UniProtKB/Swiss-Prot:O34629" /translation="MKKTLALAATAAVLMLSACSSGFGGEKEEEITQKTAKSSEKAIV PKYNISDSYYKMVLPFKAGKARGLTTEQLNTRLDIDEFETGLMRLAQDSFSTDDYLFQ EGQYLDEDTVLSWLARKKTGSDLKKAEKEDKNFKNEGLNPALPSSGSTEEKNESSPIY LASMLEHDYLVRKDKNSIQLGGVMIGLALNSVYYYREKTGDPQKEVEIKDSTLRQQGE KIAQEVINRLRKKDNLKNVPITVALYKQASKTSIVPGNFIAKTEVKAGSTDISNWDDI NEKYVFYPADTTTAEKYPDDTEVFKRFKNSIEEYFPNYTGVVGTALYENDEMKKMKID IPMQFYGKSEVVAFTQFLTGEVMDYYSKSSVDVEVNITSSDGQEAVIIRNAGDKEPTV HIYD*" /label="yerH CDS" gene 647860..649050 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /label="yerH gene" misc_feature complement(648055..648059) /Source="Nicolas_upshift_promotors" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(648059) /Source="Nicolas_upshifts" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 649087..649106 /Source="Nicolas_upshift_promotors" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 649095..649211 /Source="Nicolas_S_feature" /locus_tag="new_724870_724986" /HighExp="LoTm, B60, Lbstat, B36, BI, M9-stat, T1.30H, ferm, T3.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S234" upshifts 649095 /Source="Nicolas_upshifts" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(649159) /Source="Nicolas_upshifts" /id="D327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="1.21197" /MaxDrop="3.77048" /score="18.5253059" /energy="-17.7" /TU="NA" /idTUdmin="U511" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" CDS 649212..650222 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase" /protein_id="NP_388546.1" /db_xref="EnsemblGenomes-Gn:BSU06640" /db_xref="EnsemblGenomes-Tr:CAB12484" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG12837" /db_xref="UniProtKB/Swiss-Prot:O34640" /translation="MLDVHKDIKKIFHEEQVLAEAAARYGFSKDQVRFLADAENYVYE CMKDNQPYILKITHTIRRSSDYMMGEMEWLRHLAIGGISVAKPLPSLNGKDVEAVPDG NGGSFLLRVYEKAPGQKVDESDWNETLFYELGRYTGSMHSLTKSYKLSNPAFKRQEWD EEEQLKLRKYVPEDQIKVFQQADSLMNELRRLPKSQDNYGLVHADLHHGNFNWDHGKI TAFDFDDIGYNWFVNDISILLYNVLWYPVVPYDDKAAFTEEFMTHFMKGYWEENELDP AWLMIIPDFLRLRHMLIYGLLHQMFDLNTIGEEEKEMLAGFRRDIENGTPITAFDFSA LV*" /label="yerI CDS" gene 649212..650222 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /label="yerI gene" promotor_no_box complement(649229..649329) /Source="Nicolas_upshift_promotors" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(649269) /Source="Nicolas_upshifts" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 650205 /Source="Nicolas_upshifts" /id="D328" /incds=0 /nref=137 /ntot=253 /MaxReadThrough="3.07041" /MaxDrop="5.10987" /score="12.7441524" /energy="-17" /TU="NA" /idTUdmin="U507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 650249..651053 /Source="Nicolas_S_feature" /locus_tag="new_726024_726828" /HighExp="B60, B36, LoTm, M9-stat, Cold, T1.30H, T0.30H, ferm, Lbstat, LBGstat" /AntisenseName="sapB" /AntisenseCor="-0.57665624439942198" /AntisenseRegPval="-24.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S235" CDS complement(650260..650958) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 410907, 9043134, 14708580, 27350030, 28181542; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative magnesium transporter" /protein_id="NP_388547.1" /db_xref="EnsemblGenomes-Gn:BSU06650" /db_xref="EnsemblGenomes-Tr:CAB12485" /db_xref="GOA:Q45514" /db_xref="InterPro:IPR003416" /db_xref="SubtiList:BG11845" /db_xref="UniProtKB/Swiss-Prot:Q45514" /translation="MLLSWYIDPDILLKLGIATLIGMVIGLERELKNKPLGLKTCIVI AVSSCMLTIVSINAAYHFPKYYRIMMDPLRLPAQIISGVGFIGAGVILRKSNDVISGL TTSAMIWGAAGLGLATGAGFYKEAFASLLFILISVEFLPWVVRKIGPDRLQEKDIRIR MSLSDKDKMTEILKEMKRRDIKAHSVRIDDLGEKDFPIMEVKVRVHKNRYTTDVYYDI KAIEGVVGVKCDTL*" /label="sapB CDS" gene complement(650260..650958) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /label="sapB gene" downshifts complement(650281) /Source="Nicolas_upshifts" /id="D329" /incds=0 /nref=26 /ntot=129 /MaxReadThrough="2.5379" /MaxDrop="3.83708" /score="20.8493264" /energy="-16.2" /TU="NA" /idTUdmin="U511" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(650978..650996) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(650999) /Source="Nicolas_upshifts" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(651012..651017) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(651065..652543) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline transporter" /protein_id="NP_388548.1" /db_xref="EnsemblGenomes-Gn:BSU06660" /db_xref="EnsemblGenomes-Tr:CAB12486" /db_xref="GOA:O06493" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12641" /db_xref="UniProtKB/Swiss-Prot:O06493" /translation="MSIEIIISLGIYFIAMLLIGWYAFKKTTDINDYMLGGRGLGPFV TALSAGAADMSGWMLMGVPGAMFATGLSTLWLALGLTIGAYSNYLLLAPRLRAYTEAA DDAITIPDFFDKRFQHSSSLLKIVSALIIMIFFTLYTSSGMVSGGRLFESAFGADYKL GLFLTTAVVVLYTLFGGFLAVSLTDFVQGAIMFAALVLVPIVAFTHVGGVAPTFHEID AVNPHLLDIFKGASVISIISYLAWGLGYYGQPHIIVRFMAIKDIKDLKPARRIGMSWM IITVLGSVLTGLIGVAYAHKFGVAVKDPEMIFIIFSKILFHPLITGFLLSAILAAIMS SISSQLLVTASAVTEDLYRSFFRRKASDKELVMIGRLSVLVIAVIAVLLSLNPNSTIL DLVGYAWAGFGSAFGPAILLSLYWKRMNEWGALAAMIVGAATVLIWITTGLAKSTGVY EIIPGFILSMIAGIIVSMITKRPAKASYRLFGVMEKLLKRKK*" /label="opuE CDS" gene complement(651065..652543) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /label="opuE gene" downshifts complement(651079) /Source="Nicolas_upshifts" /id="D330" /incds=0 /nref=43 /ntot=142 /MaxReadThrough="5.35634" /MaxDrop="4.34381" /score="9.43100511" /energy="-13.8" /TU="U512,U513" /idTUdmin="U511" /TUdmin="-798" /isTUend="FALSE" /label="downshifts" upshifts complement(651931) /Source="Nicolas_upshifts" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(651934..651947) /Source="Nicolas_upshift_promotors" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(652544..652674) /Source="Nicolas_S_feature" /locus_tag="new_728319_728449_c" /HighExp="Salt, HiOs, Etha, Gly, MG 25, MG 45, M9-exp, MG t5, MG 15, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.954" /TUlongSig="NA" /TUlongPSig="NA" /label="S236" promotor_-10 complement(652665..652683) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(652674) /Source="Nicolas_upshifts" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(652698..652704) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 652805..652808 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 652823..652956 /Source="Nicolas_S_feature" /locus_tag="new_728598_728731" /HighExp="G180, G150, LBGexp, Oxctl, Paraq, dia0, G135, Lbexp, H2O2, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S237" upshifts 652823 /Source="Nicolas_upshifts" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 652825..652844 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 652957..653247 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9342321, 11445070, 12682299, 25005615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9342321, 11445070, 12682299, 25005615; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit C)" /protein_id="NP_388549.1" /db_xref="EnsemblGenomes-Gn:BSU06670" /db_xref="EnsemblGenomes-Tr:CAB12487" /db_xref="GOA:O06492" /db_xref="InterPro:IPR003837" /db_xref="InterPro:IPR036113" /db_xref="SubtiList:BG12838" /db_xref="UniProtKB/Swiss-Prot:O06492" /translation="MSRISIEEVKHVAHLARLAITEEEAKMFTEQLDSIISFAEELNE VNTDNVEPTTHVLKMKNVMREDEAGKGLPVEDVMKNAPDHKDGYIRVPSILD*" /label="gatC CDS" gene 652957..653247 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /label="gatC gene" CDS 653263..654720 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit A)" /protein_id="NP_388550.1" /db_xref="EnsemblGenomes-Gn:BSU06680" /db_xref="EnsemblGenomes-Tr:CAB12488" /db_xref="GOA:O06491" /db_xref="InterPro:IPR000120" /db_xref="InterPro:IPR004412" /db_xref="InterPro:IPR020556" /db_xref="InterPro:IPR023631" /db_xref="InterPro:IPR036928" /db_xref="SubtiList:BG12839" /db_xref="UniProtKB/Swiss-Prot:O06491" /translation="MSLFDHKITELKQLIHKKEIKISDLVDESYKRIQAVDDKVQAFL ALDEERARAYAKELDEAVDGRSEHGLLFGMPIGVKDNIVTKGLRTTCSSKILENFDPI YDATVVQRLQDAEAVTIGKLNMDEFAMGSSTENSAYKLTKNPWNLDTVPGGSSGGSAA AVAAGEVPFSLGSDTGGSIRQPASFCGVVGLKPTYGRVSRYGLVAFASSLDQIGPITR TVEDNAFLLQAISGVDKMDSTSANVDVPDFLSSLTGDIKGLKIAVPKEYLGEGVGKEA RESVLAALKVLEGLGATWEEVSLPHSKYALATYYLLSSSEASANLARFDGIRYGYRTD NADNLIDLYKQTRAEGFGNEVKRRIMLGTFALSSGYYDAYYKKAQKVRTLIKKDFEDV FEKYDVIVGPTTPTPAFKIGENTKDPLTMYANDILTIPVNLAGVPGISVPCGLADGLP LGLQIIGKHFDESTVYRVAHAFEQATDHHKAKPEL*" /label="gatA CDS" gene 653263..654720 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /label="gatA gene" CDS 654734..656164 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit B)" /protein_id="NP_388551.2" /db_xref="EnsemblGenomes-Gn:BSU06690" /db_xref="EnsemblGenomes-Tr:CAB12489" /db_xref="GOA:O30509" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR004413" /db_xref="InterPro:IPR006075" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR017958" /db_xref="InterPro:IPR017959" /db_xref="InterPro:IPR018027" /db_xref="InterPro:IPR023168" /db_xref="SubtiList:BG12840" /db_xref="UniProtKB/Swiss-Prot:O30509" /translation="MNFETVIGLEVHVELKTKSKIFSSSPTPFGAEANTQTSVIDLGY PGVLPVLNKEAVEFAMKAAMALNCEIATDTKFDRKNYFYPDNPKAYQISQFDKPIGEN GWIEIEVGGKTKRIGITRLHLEEDAGKLTHTGDGYSLVDFNRQGTPLVEIVSEPDIRT PEEAYAYLEKLKSIIQYTGVSDCKMEEGSLRCDANISLRPIGQEEFGTKTELKNLNSF AFVQKGLEHEEKRQEQVLLSGGVIQQETRRYDEATKKTILMRVKEGSDDYRYFPEPDL VELYIDDEWKERVKASIPELPDERRKRYIEELGLPAYDAMVLTLTKEMADFFEETVQK GAEAKQASNWLMGEVSAYLNAEQKELADVALTPEGLAGMIKLIEKGTISSKIAKKVFK ELIEKGGDAEKIVKEKGLVQISDEGVLLKLVTEALDNNPQSIEDFKNGKDRAIGFLVG QIMKASKGQANPPMVNKILLEEIKKR*" /label="gatB CDS" gene 654734..656164 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /label="gatB gene" downshifts 656145 /Source="Nicolas_upshifts" /id="D331" /incds=0 /nref=257 /ntot=266 /MaxReadThrough="1.62334" /MaxDrop="8.77378" /score="26.1218607" /energy="-9.6" /TU="NA" /idTUdmin="U514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(656179..657048) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388552.1" /db_xref="EnsemblGenomes-Gn:BSU06700" /db_xref="EnsemblGenomes-Tr:CAB12490" /db_xref="GOA:O31500" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG12841" /db_xref="UniProtKB/Swiss-Prot:O31500" /translation="MNEKKERIIKTSIRLFAKKGFAATTIQEIASECGISKGAFYLHF KSKEALLLSACEYYIGMSMNKMKNIEEDLAGKPPKEVLKKQIGAQFEDFRDHKDFIVL LLTENIIPENQEIKQYFYKVTMETDKLYRNALLVSYGEGIERYVADLSIMARGIVHSY MNVMVFNGELNIDAEEISAFIIERLDDLVQGLSRSALNPIVSKDIFNPMPAGKDQLLE DIQKVKENSTLPEDITVSLDVIEEELTQDKPRKPIIKGMLSNLAGTNDKEVERLRALI LSLSQFDHKKSSL*" /label="yerO CDS" gene complement(656179..657048) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /label="yerO gene" downshifts complement(656221) /Source="Nicolas_upshifts" /id="D332" /incds=0 /nref=122 /ntot=211 /MaxReadThrough="2.21801" /MaxDrop="4.89305" /score="32.2694333" /energy="-11.4" /TU="NA" /idTUdmin="U517" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 656838..656843 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-35" promotor_-10 656859..656877 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-10" upshifts 656871 /Source="Nicolas_upshifts" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="upshifts" S_feature complement(657049..657123) /Source="Nicolas_S_feature" /locus_tag="new_732824_732898_c" /HighExp="C30, S1, T3.0H, T4.0H, Salt, T5.0H, T2.0H, T3.30H, MG 150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S238" promotor_-35 657101..657108 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(657117..657136) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 657123 /Source="Nicolas_upshifts" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 657124..657143 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(657130) /Source="Nicolas_upshifts" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(657151..657158) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-35" CDS 657180..660338 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11709341, 15066026, 15941986, 25366377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11709341, 15066026, 15941986, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter involved in surfactin self-resistance" /protein_id="NP_388553.2" /db_xref="EnsemblGenomes-Gn:BSU06710" /db_xref="EnsemblGenomes-Tr:CAB12491" /db_xref="GOA:O31501" /db_xref="InterPro:IPR001036" /db_xref="InterPro:IPR027463" /db_xref="SubtiList:BG12842" /db_xref="UniProtKB/Swiss-Prot:O31501" /translation="MNHVINFVLKNKFAVWLMTIIVTAAGLYAGMNMKQESIPDVNMP YLTISTTYPGATPSQVADEVTKPVEQAVQNLDGVSVVTSTSYENASSVMIEYDYEKDM DKAKTEAAEALENVNLPDDAKDPEISRYSLNSFPILTLSVSSDKDNLQELTKQVEDSL VSKLEGIEGVASVQVSGQQVEEVEFSFKEDKLKEYGLDEDTVKQVIQGSDVTTPLGLY TFGNEEKSVVVSGDIETIKDLKNMRIPTASASSAGSSAASQAGAQSAQAAQSAQAAAQ VQQSASTAVPTVKLSDIATIKDVKKAESVSRTNGKDSIGINIVKANDANTVEVADDVK AELKKFKEDHKGFNYSATLDMAEPITQSVDTMLSKAIFGAIFAIVIILLFLRDIKSTL ISVVSIPLSLLIALLVLQQLDITLNIMTLGAMTVAIGRVVDDSIVVIENIYRRMRLKD EPLRGKALVREATKEMFKPIMSSTIVTIAVFLPLALVGGQIGELFIPFALTIVFALAA SLVISITLVPMLAHSLFKKSLTGAPIKAKEHKPGRLANIYKKVLNWALSHKWITSIIA VLMLLGSLFLVPLIGASYLPSEEEKTMQLTYSPEPGETKKEAENEAEKAEKILLDRKH VDTVQYSLGSGSPLAGGDSNGALFYIKYESDTPDFDKEKDNVLKEIQKQSDRGEWKSQ DFSSSGNNNELTYYVYGDSENDIKDTVKDIEKIMKDEKDLKNVNSGLSSTYDEYTFVA DQEKLSKLGLTASQISQALMSQTSQEPLTTVKKDGKELDVNIKTEKDEYKSVKDLENK KITSATGQEVKIGDVAKVKEGSTSDTVSKRDGKVYADVTGEVTSDNVTAVSAAIQKKI DKLDHPDNVSIDTGGVSADIADSFTKLGLAMLAAIAIVYLVLVITFGGALAPFAILFS LPFTVIGALVGLYVSGETISLNAMIGMLMLIGIVVTNAIVLIDRVIHKEAEGLSTREA LLEAGSTRLRPILMTAIATIGALIPLALGFEGGSQVISKGLGVTVIGGLISSTLLTLL IVPIVYEVLAKFRKKKPGTEEE*" /label="srfP CDS" gene 657180..660338 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /label="srfP gene" downshifts 660325 /Source="Nicolas_upshifts" /id="D333" /incds=0 /nref=76 /ntot=243 /MaxReadThrough="3.70478" /MaxDrop="4.6624" /score="-3.65521193" /energy="-12.7" /TU="U516" /idTUdmin="U516" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 660577..660580 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 660595..660614 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 660603 /Source="Nicolas_upshifts" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="upshifts" CDS 660661..661572 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /EC_number="2.7.1.107" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12682299, 17535816, 22224599, 24700682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12682299, 17535816, 22224599, 24700682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diacylglycerol kinase" /protein_id="NP_388554.1" /db_xref="EnsemblGenomes-Gn:BSU06720" /db_xref="EnsemblGenomes-Tr:CAB12492" /db_xref="GOA:O31502" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG12843" /db_xref="UniProtKB/Swiss-Prot:O31502" /translation="MKRARIIYNPTSGREIFKKHLAQVLQKFEQAGYETSTHATTCAG DATHAAKEAALREFDLIIAAGGDGTINEVVNGLAPLDNRPTLGVIPVGTTNDFARALG IPREDILKAADTVINGVARPIDIGQVNGQYFINIAGGGRLTELTYDVPSKLKTMLGQL AYYLKGMEMLPSLRPTEVEIEYDGKLFQGEIMLFLVTLTNSVGGFEKLAPDSSLNDGM FDLMILKKANLAEFIRVATMALRGEHINDQHIIYTKANRVKVNVSEKMQLNLDGEYGG MLPGEFVNLYRHIHVVMPKEKAEQLDD*" /label="dagK CDS" gene 660661..661572 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /label="dagK gene" S_feature 661573..661827 /Source="Nicolas_S_feature" /locus_tag="new_737348_737602" /HighExp="H2O2, Oxctl, Paraq, G180, Cold, C30, G150, G135, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S239" CDS 661828..663207 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /EC_number="2.1.1.189" /EC_number="2.1.1.190" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21824914" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21824914; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyltransferase of m5U747 and m5U1939 in 23S RNA" /protein_id="NP_388555.1" /db_xref="EnsemblGenomes-Gn:BSU06730" /db_xref="EnsemblGenomes-Tr:CAB12493" /db_xref="GOA:O31503" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12826" /db_xref="UniProtKB/Swiss-Prot:O31503" /translation="MKMKPPVEKNEYYDVTFEDLTHEGAGVAKVQGFPIFVPNALPEE KAQIKVTRVKKGFAFGRLIELKEESPHRTDAPCPIYKQCGGCQLQHMTYEGQLLFKQK QVKDVLERIGKLDLSKVTVHPTLGMEDPWNYRNKAQVPVGEREGGLVAGFYQQRSHDI IDMSACLIQQSKNDEAVQAVKDICANYGVKAYNEERHKGWLRHIMVRYGVVTGEMMIV FITRTSDFPHKAKIIEDITAQFPHVKSIVQNINPNKTNVIFGNETNVIWGEEYIYDLI GDVKFAISARSFYQVNPEQTKVLYDKALEYAELQGEETVIDAYCGIGTISLFLAKQAK KVYGVEIVPEAIEDAKRNAELNGNTNAEFAVGEAETVIPKWYEEGITADTLVVDPPRK GCDEALLRTIVEMKPKRVVYVSCNPGTLARDLRVLEDGGYVTREVQPVDMFPHTNHVE CCVLIKLKE*" /label="rlmCD CDS" gene 661828..663207 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /label="rlmCD gene" S_feature 663208..663800 /Source="Nicolas_S_feature" /locus_tag="new_738983_739575" /HighExp="Cold, H2O2, G135, G150, Oxctl, G180, C30, Paraq, LPh, HPh" /AntisenseName="yefB" /AntisenseCor="0.24913678485492899" /AntisenseRegPval="-4.4000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S240" CDS complement(663220..664122) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1779754, 1762151; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase / invertase; HGT island" /protein_id="NP_388556.1" /db_xref="EnsemblGenomes-Gn:BSU06740" /db_xref="EnsemblGenomes-Tr:CAB12494" /db_xref="GOA:O34574" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="SubtiList:BG12827" /db_xref="UniProtKB/Swiss-Prot:O34574" /translation="MYNEGVTSPSQLARKKNATDKWHGSSIRKILENPHYTGTLQQCR EYRPSVTSKRRRSVNLENQIIIEKSHEPIIPLEDFLIVQEILITRKRRRPQAEVHLFT NTAVCKDCRRSMHFKKNRKGYVCGSYNKHGLKACSDHYVSEIDLTDKVITNLNKIYLK FSKENYFKELSEKALKYKEKIESKIIEINEKLNDKKRDKSNLVISLANGVISKEDYQL AINITNEDISNFETTLHQLSKDLEFQKIEKEIIDFKKSLDKFMKEGTLTPEMLHLLVD EIEVHANGTIEINYRFREPTVPSA*" /label="yefB CDS" gene complement(663220..664122) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /label="yefB gene" downshifts 663757 /Source="Nicolas_upshifts" /id="D334" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="4.70474" /MaxDrop="2.82299" /score="-8.81916201" /energy="-8.8" /TU="U518" /idTUdmin="U516" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 663802..664102 /Source="Nicolas_S_feature" /locus_tag="new_739577_739877" /HighExp="H2O2, Cold, G180, G135, G150, Paraq, Oxctl, C30, LPh, LBGexp" /AntisenseName="yefB" /AntisenseCor="0.202214664414261" /AntisenseRegPval="-3.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S241" CDS 664103..664438 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative resolvase; HGT island" /protein_id="NP_388557.2" /db_xref="EnsemblGenomes-Gn:BSU06750" /db_xref="EnsemblGenomes-Tr:CAB12495" /db_xref="GOA:O35034" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG12828" /db_xref="UniProtKB/Swiss-Prot:O35034" /translation="MTPSLYNPLAIASKPFPAIYSEKILIFTIFSAFAEFERDMIVER TQEGKMLAKQNPDFREGRPKKFTKQQINHALTLLENHSYKQVEDMTGISVSTLVRAKK KKAAEAING*" /label="yefC CDS" gene 664103..664438 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /label="yefC gene" S_feature 664439..664512 /Source="Nicolas_S_feature" /locus_tag="new_740214_740287" /HighExp="G180, H2O2, G150, Cold, G135, Paraq, Oxctl, C30, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S242" CDS 664513..667152 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative restriction type II methylase; HGT island" /protein_id="NP_388558.1" /db_xref="EnsemblGenomes-Gn:BSU06760" /db_xref="EnsemblGenomes-Tr:CAB12496" /db_xref="GOA:O31504" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12818" /db_xref="UniProtKB/Swiss-Prot:O31504" /translation="MALIDLEDKIAEIVNREDHSDFLYELLGVYDVPRATITRLKKGN QNLTKRVGEVHLKNKVWFKEAKKGKLFDALIDIEQQVEYLSAKPRYLLVTDYDGVLAK DTKTLEALDVKFEELPQYFDFFLAWKGIEKVEFEKENPADIKAAERFARIYDVLRKEN NIIETNRGLDLFLIRLLFCFFAEDTDIFKRNSFTNLIKTLTEEDGSNLNKLFADLFIV LDKNERDDVPSYLKEFPYVNGQLFTEPHTELEFSAKSRKLIIECGELLNWAKINPDIF GSMIQAVASEESRSYLGMHYTSVPNIMKVIKPLFLDKLNQSFLDAYDDYTKLENLLTR IGKIKFFDPACGSGNFLIITYKELRRMEINIIKRLQELLGEYLYVPSVTLSQFYGIEI EDFAHDVAKLSLWIAEHQMNEELKNEVHNAVRPTLPLHTAGDIRCANAIRVEWTEVCP AQGSEEVYVFGNPPYLGSKKQNKEHKSDMLSIFGKVKNGKMLDYISAWFYFGAKYAST TNAKVAFVSTNSVTQGEQVSILWNELFKFGIQINFAYKSFKWANNAKNNAAVIVVIVG FGPLDTKVNKYLFVDETKKLVSNISPYLTDGENILVSSRTKPISDLPKLHFGNMPNDG GGLLFTITEYTDAINKYPELVPYFKKFIGSVEFINGGLRYCLWLNEAKYEKIKSNPLI QERISISKNHREKSTDKGTNKLALTPWKFRDTHETTNYSIVVPSVSSENRFYIPMGLA GADTILSNLIYVIYDAEIYLLGILMSRMHMTWVKAVAGRLKTDYRYSAGLCYNTFPIP ELSTRRKNEIEEAILEILDLREEQGGTLAELYNPSTMPIELKVAHEKLDGIVERAYRQ KQFESDEERLEVLLKLYQEMTER*" /label="yeeA CDS" gene 664513..667152 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /label="yeeA gene" CDS 667164..668963 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA helicase / endonuclease; HGT island" /protein_id="NP_388559.2" /db_xref="EnsemblGenomes-Gn:BSU06770" /db_xref="EnsemblGenomes-Tr:CAB12497" /db_xref="GOA:O34469" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12819" /db_xref="UniProtKB/Swiss-Prot:O34469" /translation="MENIIEINYNQTGKSKKTNEYGMREMQARAFEKRNSQYLLVKAP PASGKSRALMFIGLDKLINQGLRKVIVAVPERSIGSSFKNTDLKSYGFFENWKVDPRN NLTVGGDNSKVKSFVRFMESDDQVLICTHSTLRFAFEKIDDKAFDNCLLAIDEFHHVS ADVNSRLGELLRSIIHNSSAHIVAMTGSYFRGDSVPILLPEDEELFDKVTYSYYEQLD GYEYLKGFGIGYHFYQGQYTSAINEVLDTNKKTIVHIPNVNSGESTKDKYDEVGKILD MIGEVEYQDDDTGIIYVKRHSDGKTLKIADLVDDQVGRENVVAYLRNIEALDDLDIII ALGMAKEGFDWPFCEHTLTVGYRGSLTEIVQIIGRCTRDSYNKTYAQFTNLIAMPDAK DEVVTYTVNTMLKAISASLLMEQVLTPDFKFKRRRNESEKSSTTGELFVKGLKEPSTE NVKKIIENDINDLKAKIMQDSQVQKTFSGEVDPKVLNKVLIPKVIQKVYPNLSDEEIE EVRQHVVLDTVMKGAKSEVVGSKEFIRMADKFINIEDLDINLIDSINPFQKAFEVLSK ELNSPVLKLIQETIDAKRINFDEDELVFIWPKV*" /label="yeeB CDS" gene 667164..668963 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /label="yeeB gene" promotor_-10 complement(667404..667419) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(667419) /Source="Nicolas_upshifts" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(667431..667440) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 668964..669075 /Source="Nicolas_S_feature" /locus_tag="new_744739_744850" /HighExp="Cold, G180, G135, G150, H2O2, Paraq, HPh, LPh, Oxctl, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S243" CDS 669076..670224 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388560.2" /db_xref="EnsemblGenomes-Gn:BSU06780" /db_xref="EnsemblGenomes-Tr:CAB12498" /db_xref="InterPro:IPR018306" /db_xref="SubtiList:BG12820" /db_xref="UniProtKB/Swiss-Prot:O34352" /translation="MASNRYHSINEIMESQLFYQITTPPKKTQKAQYDPEVEKFLEII EFVKENGREPQKVPTDLTERSLASRLIGIRKDPDRMEYLKEYDEIGLLEVRSKELTIP KISSIDDILKSGLSALLGDNLNNDITRSIFDTSSLQKVTTMPEYVAKRKKIKDFGKFE ELFKKCHKEITEGKRKILTFKNEQDIQSNSFYILKGVLLYVEDVGERKKAKGKTNARL RCIFENGTESDMLLRSLSAELYKHGRRVTDNEDTLLDNVREDDVSTGFIYVLKSLSTD PQISSIKNLYKIGFTTGSVENRIRNAENQSTYLYAPVEIVTTYQVFNMNASKFETAIH HALANNNLDVSILGANGKMLVPKEWFVVTLEDLQAVIDEIVMMVHLYD*" /label="yeeC CDS" gene 669076..670224 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /label="yeeC gene" S_feature 670225..671414 /Source="Nicolas_S_feature" /locus_tag="new_746000_747189" /HighExp="Cold, G135, H2O2, G180, G150, LPh, C30, HPh, BMM, Paraq" /AntisenseName="yeeD" /AntisenseCor="-0.41772847620445203" /AntisenseRegPval="-12.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S244" CDS complement(670486..670791) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388561.1" /db_xref="EnsemblGenomes-Gn:BSU06790" /db_xref="EnsemblGenomes-Tr:CAB12499" /db_xref="SubtiList:BG12821" /db_xref="UniProtKB/Swiss-Prot:O34950" /translation="MTVRKELIKQINLTITVIKTINQKNPTPMVKNILKRYEEAKEFI LQSSDGKFEEDLSKVRNKLDTLTRAYLESANDYMNPMLKEMHKTEKLLKEYDETTQS* " /label="yeeD CDS" gene complement(670486..670791) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /label="yeeD gene" CDS complement(670858..671064) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="hypothetical protein; HGT island" /protein_id="NP_388562.1" /db_xref="EnsemblGenomes-Gn:BSU06800" /db_xref="EnsemblGenomes-Tr:CAB12500" /db_xref="GOA:O31505" /db_xref="InterPro:IPR000290" /db_xref="InterPro:IPR035900" /db_xref="SubtiList:BG12872" /db_xref="UniProtKB/Swiss-Prot:O31505" /translation="MDKLTKEELIFLVKELMNPTLDDEKVSEYLDLLEKNVPYPAPSD LIFWSNEDYTAEQVVKIALNYKDE*" /label="yezA CDS" gene complement(670858..671064) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /label="yezA gene" CDS complement(671304..671759) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="YP_003097692.1" /db_xref="EnsemblGenomes-Gn:BSU06811" /db_xref="EnsemblGenomes-Tr:CAX52579" /db_xref="InterPro:IPR006728" /db_xref="InterPro:IPR036170" /db_xref="UniProtKB/Swiss-Prot:C0H3X4" /translation="MQDLYQLIGEKLNDIIPGEWTKIYLYAEVLDDSTMVLFHFRTPE NNQIIYSQDIPSHYNVSKDIFKTLLRELRELFEELRTEHRNNNDDVWTNLTLTLDRSG EFQLDYNYDDILASELDGYERIAIWEYKNLGILPEDEDDKEFVISYLGL*" /label="yezG CDS" gene complement(671304..671759) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /label="yezG gene" downshifts complement(671317) /Source="Nicolas_upshifts" /id="D335" /incds=0 /nref=41 /ntot=213 /MaxReadThrough="4.42275" /MaxDrop="5.23695" /score="10.2582155" /energy="-11.7" /TU="U520,U521" /idTUdmin="U520" /TUdmin="-529" /isTUend="FALSE" /label="downshifts" CDS complement(671779..673788) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein; HGT island" /protein_id="NP_388563.2" /db_xref="EnsemblGenomes-Gn:BSU06812" /db_xref="EnsemblGenomes-Tr:CAB12501" /db_xref="GOA:O31506" /db_xref="InterPro:IPR006829" /db_xref="SubtiList:BG12822" /db_xref="UniProtKB/Swiss-Prot:O31506" /translation="MKVFEAKTLLSEATDRAKEYKELRTQMVNLRKALKGVADLSDSE FSGKGASNIKAFYHDHVGVADQWIDYIDMKIAFFNSIAGAAEDKGLSDAYIEESFLEH ELANANKKSKSIMSEQKKAMKDILNDIDDILPLDLFSTETFKDELADANDKRKKTLEK LDALDEDLKTEYALSEPNEQFIKSDFQKLQEATGKGKNATPIHYNAKAYRESDIHKKK GDIEKRTEAYLKIKKEEAKEREIEKLKERLKNYDYADADEFYEMAKTIGYENLTAEQQ RYFTQIENTRELEAGFKGVAVGLYDSGKDAVVGLWDMVTDPGGTVEAITGAMAHPIKT YEAISAAIEESYQKDMVNGDTYSRARWVSYAVGTVVTSIVGTKGVGAVSKTGTAAKVT TKVKTAASKSATAQKAITVSKQTVDHIKQKVNTGIEVSKKHVKTKLNQIGDLTLADIL PYHPRHDLVPAGVPYNAVNGVTLKEGLQKFAKVILPKPYGTSSSGRRTPAPHVPPVTV KYGEHFARWSRKKVLKPNIIYKTKEGYTYTTDNYGRITSVKADLQLGEAKRNQYAQTN AGKPQDRKPDDDGGHLIATQFKGSGQFDNIVPMNSQINRSGGKWYEMEQEWAKALSKK PPKKVAVQIEPVYSGDSLRPSYFDVTYKIGSRKEISVSIKNQPGG*" /label="yeeF CDS" gene complement(671779..673788) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /label="yeeF gene" promotor_-10 complement(672146..672165) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(672153) /Source="Nicolas_upshifts" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(672178..672183) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(673815..673834) /Source="Nicolas_upshift_promotors" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(673825) /Source="Nicolas_upshifts" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="upshifts" CDS 674000..675022 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage receptor protein" /protein_id="NP_388564.2" /db_xref="EnsemblGenomes-Gn:BSU06820" /db_xref="EnsemblGenomes-Tr:CAB12502" /db_xref="GOA:O31507" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12823" /db_xref="UniProtKB/Swiss-Prot:O31507" /translation="MTKKRITFGLLVLMVCVILFVLYVQLRNKDSIPVQSSAIHPEED RIFFIYSNPFIKESVLLSTSTGERFNRRTFKVADVPYIQTKSYASTDLVLLAEHEPFY YTLEKDVIKEHPLSDPFAFWYEGKDVTIEAYNVDTTGNEIHINDRKTKKEYTLTLPPL VTMGASDENFIYIIQSMSIYVIDRKTEEMIETLSLASYADQFADSEEFIVASSDHKLT VIEKGTWKTTYIAYPEDLEYADTVYYDKESGSFYVAYEDKEGGANLLEYGEDFSIHTY SLKFPYMEAKFKGNLLYIVAQEEHKKGIGGYVGVFDIHSKEMLYQFDLPEEQVKVQDF VVVDNK*" /label="yeeG CDS" gene 674000..675022 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /label="yeeG gene" promotor_-35 675122..675129 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-35" promotor_-10 675143..675162 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-10" upshifts 675144 /Source="Nicolas_upshifts" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="upshifts" CDS 675184..676314 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388565.2" /db_xref="EnsemblGenomes-Gn:BSU06830" /db_xref="EnsemblGenomes-Tr:CAB12503" /db_xref="GOA:Q59HN8" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG11031" /db_xref="UniProtKB/Swiss-Prot:Q59HN8" /translation="MSQAIPSSRVGVKINEWYKMIRQFSVPDAEILKAEVEQDIQQME EDQDLLIYYSLMCFRHQLMLDYLEPGKTYGNRPTVTELLETIETPQKKLTGLLKYYSL FFRGMYEFDQKEYVEAIGYYREAEKELPFVSDDIEKAEFHFKVAEAYYHMKQTHVSMY HILQALDIYQNHPLYSIRTIQSLFVIAGNYDDFKHYDKALPHLEAALELAMDIQNDRF IAISLLNIANSYDRSGDDQMAVEHFQKAAKVSREKVPDLLPKVLFGLSWTLCKAGQTQ KAFQFIEEGLDHITARSHKFYKELFLFLQAVYKETVDERKIHDLLSYFEKKNLHAYIE ACARSAAAVFESSCHFEQAAAFYRKVLKAQEDILKGECLYAY*" /label="rapH CDS" gene 675184..676314 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /label="rapH gene" CDS 676304..676477 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type r: regulator" /codon_start=1 /transl_table=11 /product="hexapeptide (TDRNTT) inhibitor of regulatory cascade" /protein_id="YP_003097693.1" /db_xref="EnsemblGenomes-Gn:BSU06839" /db_xref="EnsemblGenomes-Tr:CAX52580" /db_xref="GOA:Q59HN7" /db_xref="UniProtKB/Swiss-Prot:Q59HN7" /translation="MPIKKKVMMCLAVTLVFGSMSFPTLTNSGGFKESTDRNTTYIDH SPYKLSDQKKALS*" /label="phrH CDS" gene 676304..676477 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /label="phrH gene" downshifts 676432 /Source="Nicolas_upshifts" /id="D336" /incds=0 /nref=3 /ntot=66 /MaxReadThrough="5.5891" /MaxDrop="2.9063" /score="14.5772672" /energy="-7.6" /TU="U522" /idTUdmin="U522" /TUdmin="-901" /isTUend="FALSE" /label="downshifts" S_feature 676478..676582 /Source="Nicolas_S_feature" /locus_tag="new_752253_752357" /HighExp="S2, G/S, T2.30H, GM 150, T3.0H, T2.0H, S1, T-4.40H, T-2.40H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S245" promotor_-35 676549..676556 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 676571..676590 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 676584 /Source="Nicolas_upshifts" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="upshifts" CDS 676637..677356 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA integrase or transcriptional regulator" /protein_id="NP_388566.3" /db_xref="EnsemblGenomes-Gn:BSU06840" /db_xref="EnsemblGenomes-Tr:CAB12504" /db_xref="GOA:O31509" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026562" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG12824" /db_xref="UniProtKB/Swiss-Prot:O31509" /translation="MGRKWNNIKEKKASKDANTSRIYAKFGREIYVAAKQGEPDPESN QALKVVLERAKTYSVPKNIIERAIEKAKGGAEENYDELRYEGFGPNGSMIIVDALTNN VNRTAPEVRAAFGKNGGNMGVSGSVAYMFDATAVIGVEGKTADEALEILMEADVDVRD ILEEDDSAIVYAEPDQFHAVQEAFKNAGVEEFTVAELTMLAQSEVTLPDDAKEQFEKL IDALEDLEDVQQVYHNVDLGE*" /label="yeeI CDS" gene 676637..677356 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /label="yeeI gene" downshifts complement(676639) /Source="Nicolas_upshifts" /id="D337" /incds=0 /nref=3 /ntot=70 /MaxReadThrough="1.42969" /MaxDrop="3.99424" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-5851" /isTUend="FALSE" /label="downshifts" promotor_-35 677214..677221 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 677235..677254 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 677245 /Source="Nicolas_upshifts" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" downshifts 677338 /Source="Nicolas_upshifts" /id="D338" /incds=0 /nref=223 /ntot=271 /MaxReadThrough="4.94236" /MaxDrop="5.19148" /score="31.0415099" /energy="-11.4" /TU="U523,U524" /idTUdmin="U522" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 677425..677434 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 677448..677467 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 677451 /Source="Nicolas_upshifts" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(677455..677473) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(677475) /Source="Nicolas_upshifts" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(677489..677494) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 677490..677927 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 19060142, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 19060142, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore inner coat protein" /protein_id="NP_388567.2" /db_xref="EnsemblGenomes-Gn:BSU06850" /db_xref="EnsemblGenomes-Tr:CAB12505" /db_xref="GOA:O31510" /db_xref="SubtiList:BG12825" /db_xref="UniProtKB/Swiss-Prot:O31510" /translation="MTDTRHMYGGPGFGHYQGFGIGHPGYGMQSTGYPGYGMYGGHPG YGMQGYPDHGIHGGVGGYPGYGGYGGYPSGGYGGSPGTGSYPSMHHENDGHHHYYHHH HDGKDNLHHHHHHVGKDNHHHHHDGHYGHHHHHMGHWGKDGYK*" /label="cotK CDS" gene 677490..677927 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /label="cotK gene" downshifts complement(677497) /Source="Nicolas_upshifts" /id="D339" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.62645" /MaxDrop="3.26146" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-6709" /isTUend="FALSE" /label="downshifts" downshifts 677927 /Source="Nicolas_upshifts" /id="D340" /incds=0 /nref=82 /ntot=208 /MaxReadThrough="2.37564" /MaxDrop="8.21113" /score="17.7046271" /energy="-9" /TU="U525" /idTUdmin="U523" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 677987..677994 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 678010..678029 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 678015 /Source="Nicolas_upshifts" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="upshifts" CDS 678042..678626 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR family)" /protein_id="YP_054572.1" /db_xref="EnsemblGenomes-Gn:BSU06860" /db_xref="EnsemblGenomes-Tr:CAE01448" /db_xref="GOA:Q7WY76" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14194" /db_xref="UniProtKB/Swiss-Prot:Q7WY76" /translation="MGRNKEFDTALVLHRAIEVFGEYGYEGTSLQDLLSHLGIARQSL YDTYGTKRDLFLSAVKSYLEGKNAAVMERLEAPGSVKEAIRDIFQEGVNALRDPERAK ACYIINSAIEQIPHDPELARYFERQSKQLEDAFYHGLLRAKDQGELNGEDTDISALAR YLNQSRLSLTFIAKVTADMDRLQDHVDVSLSVLD*" /label="yezE CDS" gene 678042..678626 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /label="yezE gene" downshifts 678607 /Source="Nicolas_upshifts" /id="D341" /incds=0 /nref=26 /ntot=216 /MaxReadThrough="2.43615" /MaxDrop="3.31193" /score="17.7046271" /energy="-9" /TU="NA" /idTUdmin="U527" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 678705..679148 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388568.1" /db_xref="EnsemblGenomes-Gn:BSU06870" /db_xref="EnsemblGenomes-Tr:CAB12506" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:1S5A" /db_xref="SubtiList:BG12844" /db_xref="UniProtKB/Swiss-Prot:O31511" /translation="MLMNEFEKACETLRKFMAYMLEKDMKSWTELWDENAVFEFPYAP EGSPKRIEGKAAIYDYIKDYPKQIHLSSFTAPTVYRSADSNTVIAEFQCDGHVIETGL PYRQSYISVIETRDGRIVRYRDYWNPLVVKEAFGGSFLQTEESGK*" /label="yesE CDS" gene 678705..679148 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /label="yesE gene" CDS 679145..680005 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21494745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388569.1" /db_xref="EnsemblGenomes-Gn:BSU06880" /db_xref="EnsemblGenomes-Tr:CAB12507" /db_xref="GOA:O31512" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR008030" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11808" /db_xref="UniProtKB/Swiss-Prot:O31512" /translation="MMKQNPILITGGTGTVGSRIASRLIKLGYRVRIASRKKGALADA EYVYFNWKYASSFTPALEQVKQIYLVAPVGVFDPAPYVLPFLKEAKRLGAKRVVMQSA SVVSENGPVFGALHQAVREFPEWTVLRPSYFMQNFINVQHRMSIQTEGRITTASGEGK LGFIDADDIAETAVRALIDDVPHQTHHILTGPEALSYAEAAEIIGAAAGRRVEHVSIS RSELQHKMEAGGLPADYAHFMAKLDEAISHGAEHRVTDTVKRVTGKEPRSLSEFAAAH AAYWTSFWTE*" /label="yesF CDS" gene 679145..680005 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /label="yesF gene" promotor_-35 680067..680072 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 680088..680106 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 680088 /Source="Nicolas_upshifts" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(680110..680124) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(680115) /Source="Nicolas_upshifts" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(680132..680136) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 680132..680380 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388570.1" /db_xref="EnsemblGenomes-Gn:BSU06890" /db_xref="EnsemblGenomes-Tr:CAB12508" /db_xref="InterPro:IPR020256" /db_xref="SubtiList:BG11799" /db_xref="UniProtKB/Swiss-Prot:Q45536" /translation="MKDMQPFTPVKSYTPFHSRFDPCPPIGKKYYRTPPNLYMTFQPE HMEQFSPMEALRKGTLWKDLYDFYENPYRGGDAHGKKG*" /label="cotJA CDS" gene 680132..680380 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /label="cotJA gene" CDS 680364..680627 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388571.2" /db_xref="EnsemblGenomes-Gn:BSU06900" /db_xref="EnsemblGenomes-Tr:CAB12509" /db_xref="InterPro:IPR016571" /db_xref="InterPro:IPR024207" /db_xref="SubtiList:BG11800" /db_xref="UniProtKB/Swiss-Prot:Q45537" /translation="MAKKVDAEYYRQLEQIQAADFVLVELSLYLNTHPHDEDALKQFN QYSGYSRHLKRQFESSYGPLLQFGNSPAGKDWDWGKGPWPWQV*" /label="cotJB CDS" gene 680364..680627 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /label="cotJB gene" CDS 680642..681211 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /EC_number="1.11.1.6" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7768848, 9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7768848, 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="enzyme component of the inner spore coat" /protein_id="NP_388572.1" /db_xref="EnsemblGenomes-Gn:BSU06910" /db_xref="EnsemblGenomes-Tr:CAB12510" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG11801" /db_xref="UniProtKB/Swiss-Prot:Q45538" /translation="MWVYEKKLQYPVKVSTCNPTLAKYLIEQYGGADGELAAALRYLN QRYTIPDKVIGLLTDIGTEEFAHLEMIATMVYKLTKDATPEQLREAGLGDHYVNHDSA LFYHNAAGVPFTASYIQAKGDPIADLYEDIAAEEKARATYQWLIDISDDPDLNDSLRF LREREIVHSMRFREAVEILKEERDKKKIF*" /label="cotJC CDS" gene 680642..681211 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /label="cotJC gene" S_feature 681212..681290 /Source="Nicolas_S_feature" /locus_tag="new_756987_757065" /HighExp="S4, S5, S3, S7, S6, B36, LoTm, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S246" promotor_-35 681263..681268 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 681283..681302 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 681292 /Source="Nicolas_upshifts" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="upshifts" CDS 681336..681878 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388573.1" /db_xref="EnsemblGenomes-Gn:BSU06920" /db_xref="EnsemblGenomes-Tr:CAB12511" /db_xref="GOA:O31513" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11809" /db_xref="UniProtKB/Swiss-Prot:O31513" /translation="MTAFKIENETIADGFYACPAVYEDAESITGLLVRTAEWLRDRGS NQWSGLLKGQDIHDITGSIEKGHVFVFKKDEELAAVVMLLPAPSEWDRTLWGDDGHEE SIYLHRLAVSRRFAGQGLGARVLQWAETGIHFPEKTRIRLDCVADSDALHSFYRRMGY EFMGADASGYHLFEKEITAE*" /label="yesJ CDS" gene 681336..681878 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /label="yesJ gene" downshifts 681845 /Source="Nicolas_upshifts" /id="D342" /incds=0 /nref=104 /ntot=251 /MaxReadThrough="3.04389" /MaxDrop="4.5316" /score="8.56782582" /energy="-5.8" /TU="U528" /idTUdmin="U530" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS 681901..682203 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388574.2" /db_xref="EnsemblGenomes-Gn:BSU06930" /db_xref="EnsemblGenomes-Tr:CAB12512" /db_xref="GOA:O31514" /db_xref="InterPro:IPR025434" /db_xref="SubtiList:BG12845" /db_xref="UniProtKB/Swiss-Prot:O31514" /translation="MSFSKREAGDVWSILFVTGIVTACLFAGVSVLMRMRFPDKSRPE WMLAGLIVLGVFAIWYSLVYVRGWEGAALGMLGFNVIFGAIAGYLIDKAIRRYRKR*" /label="yesK CDS" gene 681901..682203 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /label="yesK gene" promotor_-35 682246..682254 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 682265..682283 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 682271 /Source="Nicolas_upshifts" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="upshifts" CDS 682318..682947 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25441682; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease or sensor of a three componentsystem for pectin and rhamnogalacturonan transport anddegradation" /protein_id="NP_388575.1" /db_xref="EnsemblGenomes-Gn:BSU06940" /db_xref="EnsemblGenomes-Tr:CAB12513" /db_xref="GOA:O31515" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12846" /db_xref="UniProtKB/Swiss-Prot:O31515" /translation="MLMIHSVANGLNHFCTWVMRLAYLNVLWILFSLAGLVVFGLMPA TAAMFTVAREWAKGNTDAPVFSVFFRTFKKEWRASQILGLIVVTAALFLFADMRIAAQ MDQPVLVNVFVSISLIFAFVVLYVFPVFSHFDVKIREVLSISFFIAFSRPAVTLLMAA GAVGVLCLVLFHVTFLLFFSGSLLSLILTKLSFKAFRSMDQRQEKEKAA*" /label="yesL CDS" gene 682318..682947 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /label="yesL gene" CDS 682944..684677 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 23436677, 25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 23436677, 25441682; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YesN]" /protein_id="NP_388576.1" /db_xref="EnsemblGenomes-Gn:BSU06950" /db_xref="EnsemblGenomes-Tr:CAB12514" /db_xref="GOA:O31516" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12847" /db_xref="UniProtKB/Swiss-Prot:O31516" /translation="MKKRVAGWYRRMKIKDKLFVFLSLIMAVSFLFVYSGVQYAFHVY DEQIYRKSSEVLRMSSERIEDELKKIEDVSYEIITDEQIQRILSMQNRDDTYDQYQMK QELWDQLAGYASDEKYIDSIHVIDARGSEYSAGSSSSDLLQQEQEEVFKRAKAKSGRN LWMTLGGSDPVLISARQIRSYHQLSLNGLGMVLIQVNVKQMIRDVPKDWGDSVGDIMI ADQGGNLVYTAHASAHVPEAAKETLKHPGYDLIKKNGKRYFISYLQSSYQNWSYYNVI PFDQMFAKISFMKTVIGTCFLLFFCVVLLFGRKIANSITEPIEQLVTAMKSVQHSGIE AGVSLSLPEHTQDEAGMLNRHFTVMMKRINELMEENVEKQLIIKETELKALQAQINPH FLYNTLESINWLAKANQQKQISKMVESLGFLLRNSIHMKKDIVTIQEEADIVRHYMTI QRFRFEERLKFTLDIDDEVKHCLIPKLTLQPLAENAIQYALEPFTRPCAIRIQAKKAK GCVCITVEDNGPGMDGRILESTGGRGIGLWNIRERISLTFGEPYGLRIHSEHEKGTRI VITIPCRNEVV*" /label="yesM CDS" gene 682944..684677 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /label="yesM gene" CDS 684677..685783 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25441682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YesM]" /protein_id="NP_388577.1" /db_xref="EnsemblGenomes-Gn:BSU06960" /db_xref="EnsemblGenomes-Tr:CAB12515" /db_xref="GOA:O31517" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12848" /db_xref="UniProtKB/Swiss-Prot:O31517" /translation="MYKILLADDERIILDGMAGIIEWESLGASLIGKAQNGHEAYEKI VHKQPHIVITDVKMPGMDGLELIKKVSAVSPSVQFIVLSGFGEFEYAKEAMKYGVKHY LLKPCNEQQIISSLEEIIAELKRQDVHKKKTAHLKHELDHIRSFAADQYLEGLIAGVA QLSPPPSLAGKKIRLLILKGEQSIDAAAREALGSALTAVCSSGEWTVLAVEENAAEKV AEVFADRKMAISQAGELRHAGQLFRDTAEASGDLHGSAVISKMIRLIADELGNPNLSL KWAAKDMLFMNPDYLGKLFKQETGEKFSQYVTRVRLEHAMKQMKIRRDVSVSEIAEEI GFGDNPKYFSLVFKKYTGLTPSEFRRKQGGASAG*" /label="yesN CDS" gene 684677..685783 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /label="yesN gene" downshifts 685737 /Source="Nicolas_upshifts" /id="D343" /incds=0 /nref=4 /ntot=43 /MaxReadThrough="0.271749999999999" /MaxDrop="3.41261" /score="3.12085441" /energy="-10.3" /TU="NA" /idTUdmin="U531" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" promotor_-35 685822..685825 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 685840..685859 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 685847 /Source="Nicolas_upshifts" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 685887..687170 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 25658435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 25658435; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="pectin degradation byproducts (rhamnose oligosaccharides)-binding lipoprotein" /protein_id="NP_388578.2" /db_xref="EnsemblGenomes-Gn:BSU06970" /db_xref="EnsemblGenomes-Tr:CAB12516" /db_xref="PDB:4R6K" /db_xref="SubtiList:BG12849" /db_xref="UniProtKB/Swiss-Prot:O31518" /translation="MKKICYVLLSLVCVFLFSGCSAGEEASGKKEDVTLRIAWWGGQP RHDYTTKVIELYEKKNPHVHIEAEFANWDDYWKKLAPMSAAGQLPDVIQMDTAYLAQY GKKNQLEDLTPYTKDGTIDVSSIDENMLSGGKIDNKLYGFTLGVNVLSVIANEDLLKK AGVSINQENWTWEDYEKLAYDLQEKAGVYGSNGMHPPDIFFPYYLRTKGERFYKEDGT GLAYQDDQLFVDYFERQLRLVKAKTSPTPDESAQIKGMEDDFIVKGKSAITWNYSNQY LGFARLTDSPLSLYLPPEQMQEKALTLKPSMLFSIPKSSEHKKEAAKFINFFVNNEEA NQLIKGERGVPVSDKVADAIKPKLNEEETNIVEYVETASKNISKADPPEPVGSAEVIK LLKDTSDQILYQKVSPEKAAKTFRKKANEILERNN*" /label="yesO CDS" gene 685887..687170 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /label="yesO gene" CDS 687167..688096 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388579.1" /db_xref="EnsemblGenomes-Gn:BSU06980" /db_xref="EnsemblGenomes-Tr:CAB12517" /db_xref="GOA:O31519" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12850" /db_xref="UniProtKB/Swiss-Prot:O31519" /translation="MTGNGADAMKKSRSIRKDNLAGYAFISPFIIGFLCFTVIPMGAS LFLSFTSYDLFTAPKWIGLDNFKEMFTGDEKYWQSLKVTFTYVLAGVPLRLGFALFIA VILNNAAKGTAIYRTLFYLPSIIGGSVAVAIMWRNIFGNDGVINALLFFVGIDQKILW YQNPTSALWTLILLSVWQFGSSMLIFLAGLKNIPSSYLEAASVDGANRVQRFFKITLP ILTPIIFFNLVMQTISAFMTFTPAYIISKGEGGPLDGTLLYSLYLFQRAFNYFQMGYA SAMAWVMLVIVGLITLILFKTSSYWVHYESKEE*" /label="rhgP CDS" gene 687167..688096 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /label="rhgP gene" CDS 688100..688990 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388580.1" /db_xref="EnsemblGenomes-Gn:BSU06990" /db_xref="EnsemblGenomes-Tr:CAB12518" /db_xref="GOA:O31520" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12851" /db_xref="UniProtKB/Swiss-Prot:O31520" /translation="MEPVNQPVREAPVFERKKAGRVSPKRILFHVFTATLAVLLLYPV IWLFVSSFKESASIFTTSHSLIPDPFILSNYAEGWKGIAGQPFLTFIKNSAIIVGLST IGAVMSSAVIAYGFARIPFKGKKFWFACMMGTLMLPHEVLMIPQYIMFAKLDWLNSFK PIVVPQFFGHAFFIFLMIQFIRTIPEELDEAARIDGCGRFACFWRIILPLIAPALATS AIFSFYWKWEELIQPLLYLNKPELYPVSLALKLFLDTESASNWGAMFAMSAVSLLPVI LVFFLFQKYIVQGISTTGLK*" /label="rhgQ CDS" gene 688100..688990 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /label="rhgQ gene" CDS 689006..690040 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /EC_number="3.2.1.172" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan hydrolase" /protein_id="NP_388581.1" /db_xref="EnsemblGenomes-Gn:BSU07000" /db_xref="EnsemblGenomes-Tr:CAB12519" /db_xref="GOA:O31521" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="SubtiList:BG12852" /db_xref="UniProtKB/Swiss-Prot:O31521" /translation="MAQLIFDEEKVTSVIDRIVKRTFQMDFAWDWPGGVAFYGVAEAY EATENEEYINLLKTWVDEQLEDGLPPLSINGVSIGHTLLFLHKVTGDDVYLETAAEMA EYVLHKAPRFGEGILQHTVNAAEYVFPEQAWADTLMMAGLFMLRIGRVMEREDYFEDG LRQFHGHEDVLQDPVTNLYYHAWDNKAQNHLSGIYWGRANGWAALTMAKALPLIEVTH PSFMIIDGSLRDQLSALVRLQDESGLWHTILDDPDSYLEVSASAGIASALMSSGKLYT KYVQKSLAAILDAVEEDGRVSRVSAGTAVMKNAEGYKQVPYKRIQGWGQGLALTFLAD VLKTKKRLYQ*" /label="rhgH CDS" gene 689006..690040 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /label="rhgH gene" CDS 690063..692348 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19651770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19651770; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AraC/XylS family)" /protein_id="NP_388582.1" /db_xref="EnsemblGenomes-Gn:BSU07010" /db_xref="EnsemblGenomes-Tr:CAB12520" /db_xref="GOA:O31522" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG12853" /db_xref="UniProtKB/Swiss-Prot:O31522" /translation="MKKQPQQKERVSRWKGTYFKRNFVFILLIACIPGLLTGGAIYFL SIDKVEKELQRSHETQVAREVSRMDEKLGVLELALTQMAYDSSLMNGLAERDLEKDFT FSYQLTKKLFLLRDQQPLIEQASIFLNSPRPLVLSPEYSALTEQEALRKYRSLLASDH SIYWKRSGNQAMLIQLIPGAAEKPFGAIMLAVDPKEMESILQSLSPYPDGSALLLDQN REVLFHEGEKDFEKTLLHEIKKQPAENGHFQMEWKGKVYSVSFGEMNRMHQQWTFVSA APLSAITAPMVFLSKVIIVMLVICIGLAVCMTWYASKKIYRPIQHLLGLFTGGEKKTW QASGQDEFKWIEKRWQDLSLESRKLQQQLLRQTPHMKKSFLQHLLQSDFYYDNEESLR FRMEEAGWNIGGNVFHVLDLQVTGLRCEKSIFREGDEQLAVFTLTNIAEELAAKRVFQ LSILDIGRLSVTVLVMKTNSSDLKAYITELARQFGDVTGLCLTSTLSSKTERVTEIPS LFQDVKCGKSRRKFANRDQVIDLQADFPRDEQFAPYYPFELEKQIVQTIRLERKQEAK ELIDGCMKELSEKAAIDRHVHSALIQLFSRIQEDILHSGLNPSELFQHRNPFLDISEL REPNEAAAWLMDVVVTPYLSKLEGRKNRQQKQLAERVIAMIHEQYMADISLESCADAL GMNSYTLSKAFKQVTGINFIDYVTQIRIEKAKELLVNTNKKIHDVSEEVGYRHNYFNR IFKKQVGMPPGVFRQMYQETP*" /label="rhgR CDS" gene 690063..692348 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /label="rhgR gene" CDS 692362..693060 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 17957779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 17957779; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388583.1" /db_xref="EnsemblGenomes-Gn:BSU07020" /db_xref="EnsemblGenomes-Tr:CAB12521" /db_xref="GOA:O31523" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12854" /db_xref="UniProtKB/Swiss-Prot:O31523" /translation="MMKKPIQVFLAGDSTVSDCPPHEAPMAGWGQVFGQLFSEGVLVR NHAKGGASTNSFVEEGRLQAIAEHITQGDYLLIQFGHNDQKPRGTKPYSTFQQFLTLF ADTAREKGAHPVFVTSVQRRRFDENGRIEHTLGEYPDAMKALAKELDVPVIDLLAKTK VLYEAYGPEESKRLFVWFQPNEHPNYPDGIEDNTHFSEKGAMEVAKLVAEGIEELGLP LKDHLVSREGKEHV*" /label="rhgT CDS" gene 692362..693060 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /label="rhgT gene" CDS 693053..693715 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388584.1" /db_xref="EnsemblGenomes-Gn:BSU07030" /db_xref="EnsemblGenomes-Tr:CAB12522" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR015305" /db_xref="PDB:1OQ1" /db_xref="SubtiList:BG12855" /db_xref="UniProtKB/Swiss-Prot:O31524" /translation="MYKEGACLYRNPLRSKSDVKDWRMEGGGQISFDDHSLHLSHVQD EAHFVFWCPETFPDGIIVTWDFSPIEQPGLCMLFFAAAGIRGEDLFDPSLRKRTGTYP EYHSGDINALHLSYFRRKYAEERAFRTCNLRKSRGFHLAAMGADPLPSPDDADSPYRM KLIKDKGYVHFSINGLPILEWMDDGSTYGPVLTKGKIGFRQMAPMKAVYRDFAVHQAV RR*" /label="yesU CDS" gene 693053..693715 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /label="yesU gene" CDS 693712..694338 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane component" /protein_id="NP_388585.1" /db_xref="EnsemblGenomes-Gn:BSU07040" /db_xref="EnsemblGenomes-Tr:CAB12523" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12856" /db_xref="UniProtKB/Swiss-Prot:O31525" /translation="MKTTVTDALYAGCEAVVKIAWLNGLWLLFTLLGGVLFGWAPSTA AMCAVIRKWLMGQKDVPIFSLFLDTYKKEFLKVNAIGLAFSALLLILSANYHYFSAST NWLSFAVTSCTLLAGLLYIIALMYVFPLYVHYQLPLRKYIPQALLFGAMRPLTTGCML IGCGFVLYLLYTLPGLIPFYGPCLFGLVLMFFALRGFQKTEAQHHQAG*" /label="yesV CDS" gene 693712..694338 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /label="yesV gene" CDS 694459..696321 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /EC_number="4.2.2.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan endolyase" /protein_id="NP_388586.1" /db_xref="EnsemblGenomes-Gn:BSU07050" /db_xref="EnsemblGenomes-Tr:CAB12524" /db_xref="GOA:O31526" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2Z8R" /db_xref="PDB:2Z8S" /db_xref="PDB:2ZUX" /db_xref="SubtiList:BG12857" /db_xref="UniProtKB/Swiss-Prot:O31526" /translation="MRRSCLMIRRRKRMFTAVTLLVLLVMGTSVCPVKAEGAARQMEA LNRGLVAVKTDGGIFVSWRFLGTENASVLFNVYRDGQKLNAAPVKTTNYVDKNGSAGS TYTVRAVVNGTEQPASEKASVWAQPYHSVPLDKPAGGTTPKGESYTYSANDASVGDVD GDGQYELILKWDPSNSKDNSQDGYTGDVLIDAYKLDGTKLWRINLGKNIRAGAHYTQF MVYDLDGDGKAEVAMKTADGTKDGTGKVIGNANADYRNEQGRVLSGPEYLTVFQGSTG KELVTANFEPARGNVSDWGDSYGNRVDRFLAGIAYLDGQRPSLIMTRGYYAKTMLVAY NFRDGKLSKLWTLDSSKSGNEAFAGQGNHNLSIADVDGDGKDEIIFGSMAVDHDGKGM YSTGLGHGDALHTGDLDPGRPGLEVFQVHEDKNAKYGLSFRDAATGKILWGVYAGKDV GRGMAADIDPRYPGQEVWANGSLYSAKGVKIGSGVPSSTNFGIWWDGDLLREQLDSNR IDKWDYQNGVSKNMLTASGAAANNGTKATPTLQADLLGDWREEVVWRTEDSSALRIYT TTIPTEHRLYTLMHDPVYRLGIAWQNIAYNQPPHTSFFLGDGMAEQPKPNMYTP*" /label="rhgW CDS" gene 694459..696321 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /label="rhgW gene" promotor_no_box 694499..694599 /Source="Nicolas_upshift_promotors" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 694559 /Source="Nicolas_upshifts" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(695097) /Source="Nicolas_upshifts" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(695098..695117) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(695130..695139) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 696367..698205 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /EC_number="4.2.2.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan exolyase" /protein_id="NP_388587.1" /db_xref="EnsemblGenomes-Gn:BSU07060" /db_xref="EnsemblGenomes-Tr:CAB12525" /db_xref="GOA:O31527" /db_xref="InterPro:IPR013517" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2ZUY" /db_xref="SubtiList:BG12858" /db_xref="UniProtKB/Swiss-Prot:O31527" /translation="MKPKKRQMEYLTRGLIAVQTEQGVFVSWRFLGTDHETTAFHLYR DGKRITRDPIAESTNFLDQNGTADSVYQVAAVNKGREEKLSKKARVWQENVLEVPLAK PEGGVTPDGKPYTYSANDASVGDIDGDGEYEMILKWDPSNSKDNAHDGYTGEVLIDAY KLDGTFLWRINLGRNIRAGAHYTQFMVYDLDGDGKAEIAMKTADGTTDGKGHIIGDEQ ADFRNEQGRILSGPEYLTVFKGETGEALTTVEYEPPRGKLEDWGDGYGNRMDRFLAGT AYLDGERPSLVMARGYYTRTVLVAYDFRNGRLKKRWVFDSNQPGHEAYAGQGNHSLSV ADVDGDGKDEIIYGAMAVDHDGTGLYSTGLGHGDAMHVGDLDPSRKGLEVFQVHEDAT KPYGLSLRDAGTGEILWGVHAGTDVGRGMAAHIDPSYKGSLVWGIDPPGNDGMSYGLF TSKGEKISDKAPSSANFAIWWDGDLVRELLDHDWDGTIGRPKIEKWDAENGCLKTIFQ PAGVLSNNGTKGNPVLQANLFGDWREEVIWRTEDSSALRIYTTTHLTRHCFYTLMHDP VYRLGIAWQNTAYNQPPHTSFYLGTGMKKPPKPALYIAGSKAEAPL*" /label="rhgX CDS" gene 696367..698205 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /label="rhgX gene" CDS 698363..699016 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388588.1" /db_xref="EnsemblGenomes-Gn:BSU07070" /db_xref="EnsemblGenomes-Tr:CAB12526" /db_xref="GOA:O31528" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12859" /db_xref="UniProtKB/Swiss-Prot:O31528" /translation="MANHIYLAGDSTVQTYGDSTNQGGWGQFLGSHLPEHIQVINRAI GGRSSKTFVEEGRLQAILDVIEPDDWLFVQMGHNDASKNKPERYTEPYTTYKQYLKQY IAGAREKGAHPLLITPVARFHYENGVFLNDFPDYCIAMKQTAAEENVQLIDLMEKSLA FFTEKGEEKVYTYFMISEGINDYTHFTKKGANEMAKLVAKGIKELGLPLTESIIKER* " /label="yesY CDS" gene 698363..699016 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /label="yesY gene" CDS 699024..701015 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17056685, 17449691, 17485082" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17056685, 17449691, 17485082; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-galacturonidase" /protein_id="NP_388589.1" /db_xref="EnsemblGenomes-Gn:BSU07080" /db_xref="EnsemblGenomes-Tr:CAB12527" /db_xref="GOA:O31529" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12860" /db_xref="UniProtKB/Swiss-Prot:O31529" /translation="MRKLYHGACYYPELWDEETIQQDIDIMREVGVNVVRIGEFAWSV MEPEEGKIDVGFFKEIIARLYDSGIETIMCTPTPTPPIWFSHGRPERMHANEKREIMG HGSRQHACTNNPYFRKKAAIITTAIAKELGRLPGLIGWQLDNEFKCHVAECMCETCLR LWHDWLKNRYGVIERLNEAWGTDVWSETYQTFEQVPQPGPAPFLHHASLRTMYQLFSM EMIASFADEQAKIIRCYSDAPITHNGSVMFSVDNERMFQNLDFASYDTYASQENASAF LLNCDLWRNLKQGRPFWILETSPSYAASLESSAYPHADGYLQAEAVSSYALGSQGFCY WLWRQQRSGSEISHGSVLSAWGEPTIGYQNVLAVERARKEIEPIILSTEPVQAEAAMT YSDRAKAFIKTEPHRGLRHRSLVTHFYERILNTGIHRDLIPEGAPLDGYRLLFTPFVP YLSSEFIKKASAFAEAGGIWITGPLTGGRTCEHTIHTDCGLGELEKTSGIKTLFTFPM NENVNTGKAFGITAPLGLWSAVFDTESGNTLGTVEAGPGAGHAFLTERNYGEGKIVML GSLPSGKEGDAMLEALVRHYAEEAVISSRSDVTPGTIVAPRIGENGLVWIVVNMDGKG GSVTLPESGTDLLTHRLEKAGRLAVGPHEYRVIQFDNHS*" /label="rhgZ CDS" gene 699024..701015 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /label="rhgZ gene" CDS 701059..703632 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388590.2" /db_xref="EnsemblGenomes-Gn:BSU07090" /db_xref="EnsemblGenomes-Tr:CAB12528" /db_xref="SubtiList:BG12861" /db_xref="UniProtKB/Swiss-Prot:O31530" /translation="MKKIKWLSGQPKVTSGVTWGMPWKKGELKKGDRLALMNENAETR YVQSEPSAYWPDGSIKWTKHAAVFGGQENQSFTVHKREVPQPTESLSILETEHDIQVD TGALVCTIHKTGSDFIQSLQINGKPIAAGGRLVAIRETRKESAAKMVLLHERSVSFIK RAAIEQSGPVKAVVKIEGVHVLHKTYEEWLPFVIRLTFYAGLSEIGLVHTQLIDRSGK LEFVKGLGIEFDLFLEGEPYNRHFRFAGEKGMYKEPAQLFGTRKFNERYPLYEKQING EMLSPDEEHKEWFAHGTQNAVWDDVKIVQDSSDHYSLSKRTGKDYAWVGMLHGSRAKG LCYAGGKNGGVALGLRYFFEKYPSALEITGLAGSRPKMTIWLWPPDGEAMDLRHYTGN THVASAYEGFDEMRSDPTGIANTNEISLACFSHMPSDEVLNALADKWQAPPLIVCEPD VYYESKALGVWSIIDTSHPLKKELEEQLDAAFLFYKKEVEQRRWYGFWHYGDVMHTYD PIRHMWRYDLGGYAWQNNELVPTLWLWQAFFRSGREDIFRMAEAMTRHTSETDSFHLG EYAGLGSRHNVVHWGCGCKEARISMAGLHKFYYYLTGDDRTGDLLTEVKDADYALVKT DPMRAFYEKGKHPTHARTGPDWAAFCSNWLAEWERTENSEYLKKIETGINCLKRLPLR LLSGPTFEYDPATSMLHHMGDGIAGGYHMIIAFGAPQVWMELAELLDDWEWEDMLSEF GEFYTLSDEEKRKKSGGALHDGHFHWPMFAAGMTAYAARKKQDPHLAAKAWNLLLEDK LSHTPLPIKPERIETWTQLEELPWVTTNTVSQWCLNVIAALELIGDSLPAKKETSGKK G*" /label="yetA CDS" gene 701059..703632 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /label="yetA gene" promotor_-10 complement(702381..702399) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(702394) /Source="Nicolas_upshifts" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(702415..702420) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 703754..705262 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921237; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein transporter binding protein for alpha-galacturonides" /protein_id="NP_388591.1" /db_xref="EnsemblGenomes-Gn:BSU07100" /db_xref="EnsemblGenomes-Tr:CAB12529" /db_xref="GOA:P37966" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG10434" /db_xref="UniProtKB/Swiss-Prot:P37966" /translation="MKIRMRKKWMALPLAAMMIAGCSHSETSNSASGSKDTIKIMAPL LSPESPSDKSPSLKALEKYTGKEIKVTWVPDSSYNDKFNIVMASGEMPHAIVIKDKSA GFIKSVKAGAFWELSPYLKDYKNLSQADEKILKNSSVNGEVYGIYRTRDLIRACMIIR TDWLKNVGLDMPETLDDFYEVLKAFKEKDPDGNGKDDTYGMVVPKWMGLGNGSPWDVL QIWFGAPNRYGVENGKLIPDFTTKEYMDALTFFKKLYDEGLINKDFAVMDSAKWNDPV VKGKAGVIVDTGSRASQIQSAMEEADESNKDIIDIVGSLEGPNGKRTFPTSGYSGMIT IPKSSVKTEKELKEVLSFLDKMNDKEAQILTNNGVKGRNYELKDGVFTSLEKNNKSLL YEHEGLAQFSMSIPKSEYYIEDQKTKLFQHRKDIITEGEKIAVFNPAESLVSDVYTQK GAQLDNIILDARTQFIIGEIDEKGFDDAVELWKKSGGNELMKDLNKLYQSSK*" /label="lplA CDS" gene 703754..705262 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /label="lplA gene" CDS 705317..706273 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388592.1" /db_xref="EnsemblGenomes-Gn:BSU07110" /db_xref="EnsemblGenomes-Tr:CAB12530" /db_xref="GOA:P39128" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10435" /db_xref="UniProtKB/Swiss-Prot:P39128" /translation="METVPKKRDAPVLTAGKGISWMAALKRDKWLYLLLIPGLLYFLI FKYLPMWGVLIAFKDYSPYLGFWKSEWVGFDYFKDFFMNPDFFRLLRNTLMLASLDLL FAFPAPLILALLLNEVRKAVYKRCIQTFIYVPHFVSWTIVVSITFVFFTVDTGVINKL IMSLTGEQISFLSDADWFRPMIVMQSIWKETGWGTILFLAALATVDQEQYEAAIMDGA GRFRRMWHITLPAIRSTIIVLLILRIGSFLNLGFEQVYLMTNSLNRSVADIFDTYVYM MGITQGAYSYSTAVGLFKSVVGIILIFGANYIAKKFDQEGLF*" /label="lplB CDS" gene 705317..706273 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /label="lplB gene" downshifts complement(705591) /Source="Nicolas_upshifts" /id="D344" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="1.59638" /MaxDrop="4.19822" /score="13.9744253" /energy="-20.3" /TU="NA" /idTUdmin="U538" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(705617..705717) /Source="Nicolas_upshift_promotors" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(705657) /Source="Nicolas_upshifts" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 706287..707174 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388593.1" /db_xref="EnsemblGenomes-Gn:BSU07120" /db_xref="EnsemblGenomes-Tr:CAB12531" /db_xref="GOA:P39129" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10857" /db_xref="UniProtKB/Swiss-Prot:P39129" /translation="MAEIHTMHNTKAGRVFDVCNILFLGGVGAITILPFLYIIAGSFA TEAELAQRSFFIFPKTFTLDAYKYVFSTPTFLRSMGVSIFITVVGTAVQLFFTFTMAY PLAKRHVKGRNLLLNLVIFSMLFSGGMIPTYLVVKSLGLLDTYWALILPMAINPFNLI IIKNFFQQLPRELEESAKIDGCSEIGVFWRIALPLSKPVIATFALFYAVGIWNDFFHA LLYINDSAKWPLQMVLRQVTILSDLTATNGDTMQNAVPPEQGIKLAVIVIATLPILAV YPFLQKHFAKGMLIGSVKG*" /label="lplC CDS" gene 706287..707174 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /label="lplC gene" promotor_-35 706921..706926 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 706942..706960 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 706945 /Source="Nicolas_upshifts" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="upshifts" CDS 707183..708523 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23416295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23416295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-galacturonidase" /protein_id="NP_388594.1" /db_xref="EnsemblGenomes-Gn:BSU07130" /db_xref="EnsemblGenomes-Tr:CAB12532" /db_xref="GOA:P39130" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:3FEF" /db_xref="SubtiList:BG10858" /db_xref="UniProtKB/Swiss-Prot:P39130" /translation="MFHISTLDQIKIAYIGGGSQGWARSLMSDLSIDERMSGTVALYD LDFEAAQKNEVIGNHSGNGRWRYEAVSTLKKALSAADIVIISILPGSLDDMEVDVHLP ERCGIYQSVGDTVGPGGIIRGLRAVPIFAEIARAIRDYAPESWVINYTNPMSVCTRVL YKVFPGIKAIGCCHEVFGTQKLLAEMVTERLGIEVPRREDIRVNVLGINHFTWITKAS YRHIDLLPIFREFSAHYGESGYELEGECWRDSVFCSAHRVAFDLFETYGAIPAAGDRH LAEFLPGPYLKQPEVWKFHLTPISFRKQDRAEKRQETERLIVQQRGVAEKASGEEGVN IIAALLGLGELVTNVNMPNQGQVLNLPIQAIVETNAFITRNRVQPILSGALPKGVEML AARHISNQEAVADAGLTKDTGLAFQAFLNDPLVQIDRSDAEQLFNDMLQCIMQS*" /label="lplD CDS" gene 707183..708523 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /label="lplD gene" S_feature complement(707617..709308) /Source="Nicolas_S_feature" /locus_tag="new_783392_785083_c" /HighExp="H2O2, dia15, Paraq, Lbexp, LBGexp, Salt, LPhT, GM 25, G150, dia0" /AntisenseName="yetF" /AntisenseCor="-0.25986434675098202" /AntisenseRegPval="-4.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S247" S_feature 708524..708605 /Source="Nicolas_S_feature" /locus_tag="new_784299_784380" /HighExp="S5, S4, S6, S3, S7, S8, BT, LoTm, B36, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S248" CDS 708606..709301 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388595.1" /db_xref="EnsemblGenomes-Gn:BSU07140" /db_xref="EnsemblGenomes-Tr:CAB12533" /db_xref="GOA:O31533" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="PDB:3C6F" /db_xref="SubtiList:BG12862" /db_xref="UniProtKB/Swiss-Prot:O31533" /translation="MGNYLSVAVELVCGLGILFIILKLLGKTQFSQITPFDFISALIL GELVGNAVYDHEIKIKEIIFASLLWGVLIYIIEFITQKMKSSRKFLEGEPNIVIRKGE LQYKVMKKNKIDINQLQSLLRQAGSFSIQEVEYAILETNGMVSVLPKSDFDKPTNKDL QIPSKSVSLPITLIIDGEIVRDNLKEAGVDEQWLKQELKKKNIDKTEDVLFAEWHKNK PLYTVTYEQSRST*" /label="yetF CDS" gene 708606..709301 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /label="yetF gene" downshifts 709299 /Source="Nicolas_upshifts" /id="D345" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.32891" /MaxDrop="3.45213" /score="-0.176154378" /energy="-7.1" /TU="NA" /idTUdmin="U537" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(709338..709664) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /EC_number="1.14.14.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20180905, 21764939, 21873409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20180905, 21764939, 21873409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388596.2" /db_xref="EnsemblGenomes-Gn:BSU07150" /db_xref="EnsemblGenomes-Tr:CAB12534" /db_xref="GOA:O31534" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12863" /db_xref="UniProtKB/Swiss-Prot:O31534" /translation="MFVQLRKMTVKEGFADKVIERFSAEGIIEKQEGLIDVTVLEKNV RRGDEEVVVMIRWESEDHWKQWEKSDAHIAGHKANKGKPKPDYLISTEVSMYHVRAVK QGTYNQ*" /label="hmoA CDS" gene complement(709338..709664) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /label="hmoA gene" downshifts complement(709353) /Source="Nicolas_upshifts" /id="D346" /incds=0 /nref=194 /ntot=248 /MaxReadThrough="4.01189" /MaxDrop="6.29183" /score="9.23596913" /energy="-9.1" /TU="U538" /idTUdmin="U539" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 709651 /Source="Nicolas_upshifts" /id="D347" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.96802" /MaxDrop="3.46057" /score="-7.34187128" /energy="-5" /TU="NA" /idTUdmin="U537" /TUdmin=352 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(709687..709706) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(709705) /Source="Nicolas_upshifts" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(709721..709728) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(709768..710130) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase/dioxygenase" /protein_id="NP_388597.1" /db_xref="EnsemblGenomes-Gn:BSU07160" /db_xref="EnsemblGenomes-Tr:CAB12535" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12864" /db_xref="UniProtKB/Swiss-Prot:O31535" /translation="MIKQIGTVAVYVEDQQKAKQFWTEKVGFDIAADHPMGPEASWLE VAPKGAETRLVIYPKAMMKGSEQMKASIVFECEDIFGTYEKMKTNGVEFLGEPNQMEW GTFVQFKDEDGNVFLLKE*" /label="yetH CDS" gene complement(709768..710130) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /label="yetH gene" promotor_-10 complement(710153..710172) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-10" upshifts complement(710167) /Source="Nicolas_upshifts" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="upshifts" promotor_-35 complement(710185..710191) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-35" S_feature complement(710201..710761) /Source="Nicolas_S_feature" /locus_tag="new_785976_786536_c" /HighExp="S8, S6, S7, S5, BT, B36, G/S, B60, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S249" downshifts complement(710233) /Source="Nicolas_upshifts" /id="D348" /incds=0 /nref=38 /ntot=47 /MaxReadThrough="0.395850000000001" /MaxDrop="8.2984" /score="45.4672528" /energy="-13.7" /TU="NA" /idTUdmin="U540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(710744..710763) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(710761) /Source="Nicolas_upshifts" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(710777..710786) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 710849..710856 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 710865 /Source="Nicolas_upshifts" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 710869..710888 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 710914..711495 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; N-terminal part of YetI" /db_xref="SubtiList:BG12865" /translation="MNIDQLLYQYIIDNTADITEKWFSLRCQLKGELYSASHLSEETK TLLTEQHTFTNITIASAFLEDQTDFQENMTKWAQNVAKNRVEQDVQVHEVVEAISNSR ISFWDAVATFIKENQEIVTNEDADRWNRIVNQSFDKLIIEFSEQYQKFMLMRLTSQQE LISELGCPVISIADGIGILPLIGSIDTKRHRSF*" /label="yetI CDS" gene 710914..711495 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /pseudo /label="yetI gene" CDS 711489..711785 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; C-terminal part of YetI" /db_xref="GOA:O31537" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="PSEUDO:CAB12537.2" /db_xref="SubtiList:BG12873" /db_xref="UniProtKB/Swiss-Prot:O31537" /translation="MLETVPVRCVERKITSLVVDLSGVPIVDTMVAQQLYNLSKTLFL LGVKAVFSGIRPDVAQTSIQLGLDFSEYETYGTLKQALENMGVRCIVEELEENK*" /label="yetI CDS" gene 711489..711785 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /pseudo /label="yetI gene" downshifts 711777 /Source="Nicolas_upshifts" /id="D349" /incds=0 /nref=114 /ntot=215 /MaxReadThrough="1.06939" /MaxDrop="4.8053" /score="16.356572" /energy="-21.2" /TU="NA" /idTUdmin="U541" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 711856..711863 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 711877..711896 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 711885 /Source="Nicolas_upshifts" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 711940..712107 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388600.1" /db_xref="EnsemblGenomes-Gn:BSU07190" /db_xref="EnsemblGenomes-Tr:CAB12538" /db_xref="InterPro:IPR018743" /db_xref="SubtiList:BG12875" /db_xref="UniProtKB/Swiss-Prot:O31538" /translation="MVSKSTIDPEVIEKIISSLETLDFGTVQITVHDSQITQIEKIEK HRFSLKRKESK*" /label="yezD CDS" gene 711940..712107 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /label="yezD gene" promotor_-35 712149..712156 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 712172..712191 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 712173 /Source="Nicolas_upshifts" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 712217..712861 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /function="7.4: Cations and iron carrying compounds" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 16086852, 24904158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 16086852, 24904158; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pH-sensitive calcium-leak permease (di-aspartyl pH sensor)" /protein_id="NP_388601.1" /db_xref="EnsemblGenomes-Gn:BSU07200" /db_xref="EnsemblGenomes-Tr:CAB12539" /db_xref="GOA:O31539" /db_xref="InterPro:IPR006214" /db_xref="PDB:4PGR" /db_xref="PDB:4PGS" /db_xref="PDB:4PGU" /db_xref="PDB:4PGV" /db_xref="PDB:4PGW" /db_xref="PDB:4TKQ" /db_xref="SubtiList:BG12866" /db_xref="UniProtKB/Swiss-Prot:O31539" /translation="MQATVHESKQSIMQRILTVFVFTLLIATVGLFIGQFVPVALMLP LSILEVAMIILAFWMRRRKAVGYAFVYTFAFVSGITLFPIVSHYASIAGAYVVLEAFG STFVIFAVLGTIGAKMKKDLSFLWSFLLVAVLALAVVGIFNIFSPLNSAAMMAYSVIG TIVFSLYILYDLNQIKHRHITEDLIPVMALSLYLDFINLFINLLRFFGILSSDD*" /label="calJ CDS" gene 712217..712861 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /label="calJ gene" downshifts 712797 /Source="Nicolas_upshifts" /id="D350" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="6.69003" /MaxDrop="2.5446" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U541" /TUdmin=1012 /isTUend="FALSE" /label="downshifts" downshifts 712841 /Source="Nicolas_upshifts" /id="D351" /incds=0 /nref=7 /ntot=127 /MaxReadThrough="5.33515" /MaxDrop="3.71552" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" CDS 712861..713853 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388602.1" /db_xref="EnsemblGenomes-Gn:BSU07210" /db_xref="EnsemblGenomes-Tr:CAB12540" /db_xref="GOA:O31540" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12867" /db_xref="UniProtKB/Swiss-Prot:O31540" /translation="MKKRLSLDRRFLPYIKKAGGVLVKKQMGAYVSLAAAMAIVGSSV VVGKLMVERIPVFLSSGLRFLIASVVLLMLLFCIEKGFPALTKKDVFVLLVQSFTGVF LFSICLLYGVQYTTGTESGILTSTTPMLIGILSFFLLREKIEKKTLIGILLAVCGVMA INLFGAGSQDGTPHALFGNMLIIAAVIGEALFTLMAKLLSPHISALAISTFVSLFGFL FFLPFALFEASSFDYSVPTVLDWSYVLYYALFVTVLAFYLWYSGVTKVPAGVSGIFTS VLPVSAVILSGVILKEPFEFVHFIGIACVIGGIFVTVIKKKQPDAYPAAEEKTL*" /label="yetK CDS" gene 712861..713853 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /label="yetK gene" downshifts 713787 /Source="Nicolas_upshifts" /id="D352" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="4.14475" /MaxDrop="2.73453" /score="21.8095329" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 713831 /Source="Nicolas_upshifts" /id="D353" /incds=0 /nref=94 /ntot=214 /MaxReadThrough="0.120229999999999" /MaxDrop="4.45909" /score="21.8095329" /energy="-10.7" /TU="NA" /idTUdmin="U542" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(713877..714380) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19329649, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19329649, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (FlvL-flavonoids)" /protein_id="NP_388603.1" /db_xref="EnsemblGenomes-Gn:BSU07220" /db_xref="EnsemblGenomes-Tr:CAB12541" /db_xref="GOA:O31541" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12868" /db_xref="UniProtKB/Swiss-Prot:O31541" /translation="MELKHLPKYKHITEHAETYANIDAGSLELFLSLFDISKKMNHVM EHYFAGRGLSEGKFKILMLLFDAKDHRLSPTELAKRSNVTKATITGLLDGLARDGFVS RRHHTEDKRKISIELTTEGKARLEQFLPGHFSKISAVMENYSDEEKDMFVKMLGDLFE RLSVFKD*" /label="flvL CDS" gene complement(713877..714380) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /label="flvL gene" promotor_-10 complement(714405..714424) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(714413) /Source="Nicolas_upshifts" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(714438..714445) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 714543..715652 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25209494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-dependent hydroxylase/monooxygenase acting on salicylate derivatives" /protein_id="NP_388604.1" /db_xref="EnsemblGenomes-Gn:BSU07230" /db_xref="EnsemblGenomes-Tr:CAB12542" /db_xref="GOA:O06489" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12869" /db_xref="UniProtKB/Swiss-Prot:O06489" /translation="MKHMLIAGGGIGGLSAAISLRKAGFSVTLCEAASENRKTGAGIL QPQNALAVLKELGVFEDCCKHGFQTEWFKTFDEQGNLLFQVSESFLDDSLPGRNNILR KTLNDILMKHAEAVGVDIKWGKKVVAYEETAESVTALCEDGEKMQADILAGFDGIHSV VRDKMLQKETEKEHLGMGAWRFYIELPDYTFEDATFMYRSGDTQIGVVPLAQHAGYVF VLQPCTSDYWDEEDTRFDRVKEILSGFRGLDFVTKHMSKQHPVIFNKLEQVAVQEPWH KGRVIIGGDAAHAGAPTLAQGAAMAIEDAIVLAEELQNHADHETALQAYYKRRAPRAL KVQNLSSEIVRRRLKGEPGAEELIGECYAVLREGY*" /label="flvM CDS" gene 714543..715652 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /label="flvM gene" downshifts 715635 /Source="Nicolas_upshifts" /id="D354" /incds=0 /nref=7 /ntot=67 /MaxReadThrough="0.0953400000000002" /MaxDrop="5.1482" /score="13.261567" /energy="-12.6" /TU="NA" /idTUdmin="U542" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS complement(715687..716757) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388605.1" /db_xref="EnsemblGenomes-Gn:BSU07240" /db_xref="EnsemblGenomes-Tr:CAB12543" /db_xref="InterPro:IPR025006" /db_xref="InterPro:IPR025012" /db_xref="SubtiList:BG12870" /db_xref="UniProtKB/Swiss-Prot:O06490" /translation="MDFEIRFLSFYVIQVEGKDEQANKQFKHFQTLDTGEFEESELKD FLDGELKKIVKRKADRHPQSEQVPTKIGHFIVEPGHELDSNPNYNMFNRARLAETKED FNELSEQFVRTYLDTSAVRGGVFLVASAVPRKYFDESFVFIMKCDFEPKVARISDASS LIKKVEMAITTKNMKSIQYPYMPEEGMVEEGELKIHQASHARYFEDFLKFVEYGESMP EIMKNQVMNMVQEHVYETFEDNSEELKQFEHDIEIWEASEKREIQERLDTHQVIEASA QIIEHTPEAQLKMKVGETEIKGLLADFGDSIHLAKVNGRYVALIEAETISFEKGSSPV EFYKPEGLHEVIERIRNKTEQD*" /label="yetN CDS" gene complement(715687..716757) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /label="yetN gene" downshifts complement(715711) /Source="Nicolas_upshifts" /id="D355" /incds=0 /nref=45 /ntot=180 /MaxReadThrough="0.83729" /MaxDrop="4.28938" /score="0.323038441" /energy="-11.6" /TU="NA" /idTUdmin="U545" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(716788..716807) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(716814) /Source="Nicolas_upshifts" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(716822..716829) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 716837..716843 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 716858..716876 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 716867 /Source="Nicolas_upshifts" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="upshifts" CDS 716907..720092 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /EC_number="1.6.2.4" /EC_number="1.14.14.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11574077, 2544578, 21048857, 26452461; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional P-450/NADPH-P450 reductase 1" /protein_id="NP_388606.1" /db_xref="EnsemblGenomes-Gn:BSU07250" /db_xref="EnsemblGenomes-Tr:CAB12544" /db_xref="GOA:O08394" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12871" /db_xref="UniProtKB/Swiss-Prot:O08394" /translation="MKETSPIPQPKTFGPLGNLPLIDKDKPTLSLIKLAEEQGPIFQI HTPAGTTIVVSGHELVKEVCDEERFDKSIEGALEKVRAFSGDGLFTSWTHEPNWRKAH NILMPTFSQRAMKDYHEKMVDIAVQLIQKWARLNPNEAVDVPGDMTRLTLDTIGLCGF NYRFNSYYRETPHPFINSMVRALDEAMHQMQRLDVQDKLMVRTKRQFRYDIQTMFSLV DSIIAERRANGDQDEKDLLARMLNVEDPETGEKLDDENIRFQIITFLIAGHETTSGLL SFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLELTYIRMILNESLRLWPTAPAF SLYPKEDTVIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEFRPERFEHQDQVPHHA YKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDHENYELDIKQTLTLKPGDFHIS VQSRHQEAIHADVQAAEKAAPDEQKEKTEAKGASVIGLNNRPLLVLYGSDTGTAEGVA RELADTASLHGVRTKTAPLNDRIGKLPKEGAVVIVTSSYNGKPPSNAGQFVQWLQEIK PGELEGVHYAVFGCGDHNWASTYQYVPRFIDEQLAEKGATRFSARGEGDVSGDFEGQL DEWKKSMWADAIKAFGLELNENADKERSTLSLQFVRGLGESPLARSYEASHASIAENR ELQSADSDRSTRHIEIALPPDVEYQEGDHLGVLPKNSQTNVSRILHRFGLKGTDQVTL SASGRSAGHLPLGRPVSLHDLLSYSVEVQEAATRAQIRELASFTVCPPHRRELEELSA EGVYQEQILKKRISMLDLLEKYEACDMPFERFLELLRPLKPRYYSISSSPRVNPRQAS ITVGVVRGPAWSGRGEYRGVASNDLAERQAGDDVVMFIRTPESRFQLPKDPETPIIMV GPGTGVAPFRGFLQARDVLKREGKTLGEAHLYFGCRNDRDFIYRDELERFEKDGIVTV HTAFSRKEGMPKTYVQHLMADQADTLISILDRGGRLYVCGDGSKMAPDVEAALQKAYQ AVHGTGEQEAQNWLRHLQDTGMYAKDVWAGI*" /label="cypD CDS" gene 716907..720092 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /label="cypD gene" downshifts 720079 /Source="Nicolas_upshifts" /id="D356" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.31156" /MaxDrop="2.91666" /score="9.17315362" /energy="-9.8" /TU="NA" /idTUdmin="U546" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 720142..720147 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 720163..720181 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 720184 /Source="Nicolas_upshifts" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 720212..720215 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 720232..720251 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 720233..720538 /Source="Nicolas_S_feature" /locus_tag="new_796008_796313" /HighExp="H2O2, Paraq, Oxctl, Cold, Heat, LBGexp, G180, G150, HPh, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.841" /TUlongSig="NA" /TUlongPSig="NA" /label="S250" upshifts 720233 /Source="Nicolas_upshifts" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" CDS 720539..722458 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11544192, 15187182, 17434969, 17483484, 21255105, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="exported glycerol phosphate lipoteichoic acid synthetase and anion-binding protein" /protein_id="NP_388607.2" /db_xref="EnsemblGenomes-Gn:BSU07260" /db_xref="EnsemblGenomes-Tr:CAB12545" /db_xref="GOA:Q797B3" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG12980" /db_xref="UniProtKB/Swiss-Prot:Q797B3" /translation="MKKLFSYKLSFFVLAVILFWAKTYLSYKTEFNLGVKGTTQEILL IFNPFSSAVFFLGLALLAKGRKSAIIMLIIDFLMTFVLYANILFYRFFDDFLTFPNIK QSGNVGNMGDGIFSIMAGHDIFYFLDIIILIAVLIWRPELKEYKMKKRFASLVILSGI ALFFINLHYAEKDRPQLLTRTFDRNYIVKYLGLYNYTIYDGVQTAQTETQRAYASSDD LTSVENYTTSHYAKPNAEYFGSAKGKNIIKIHLESFQSFLIDYKLNGEEVTPFLNKLA HGGEDVTYFDNFFHQTGQGKTSDAELTMDNSIFGLPEGSAFVTKGENTYQSLPAILDQ KEGYTSAVLHGDYKSFWNRDQIYKHIGYDKFFDASTYDMSDENVINMGLKDKPFFTES IPKLESLKQPFYAHLITLTNHYPFNLDEKDASLKKATTGDNTVDSYFQTARYLDEALE QFFKELKEAGLYDNSVIMIYGDHNGISENHNRAMKEILGKEITDYQNAQNQRVPLMIR VPGKKGGVNHTYGGEIDVMPTLLHLEGIDSQKYINFGTDLFSKDHDDTVAFRNGDFVT PKYTSVDNIIYDTKTGEKLKANEETKNLKTRVNQQLSLSDSVLYKDLLRFHKLNDFKA VDPSDYHYGKEKEIK*" /label="ltaSA CDS" gene 720539..722458 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /label="ltaSA gene" downshifts 722457 /Source="Nicolas_upshifts" /id="D357" /incds=0 /nref=103 /ntot=261 /MaxReadThrough="1.69168" /MaxDrop="7.8227" /score="37.7648461" /energy="-24" /TU="NA" /idTUdmin="U547" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 722546..722555 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 722565..722693 /Source="Nicolas_S_feature" /locus_tag="new_798340_798468" /HighExp="BT, B36, S8, S7, G/S, Pyr, B60, S6, Glucon, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S251" upshifts 722565 /Source="Nicolas_upshifts" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 722569..722588 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(722619) /Source="Nicolas_upshifts" /id="D358" /incds=0 /nref=2 /ntot=6 /MaxReadThrough="1.80969" /MaxDrop="4.63324" /score="20.6569889" /energy="-23.4" /TU="NA" /idTUdmin="U552" /TUdmin=4928 /isTUend="FALSE" /label="downshifts" CDS 722694..723458 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /EC_number="2.7.7.33" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15634670, 16357223, 26577401" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15634670, 16357223, 26577401; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate cytidylyltransferase (sporulation)" /protein_id="NP_388608.1" /db_xref="EnsemblGenomes-Gn:BSU07270" /db_xref="EnsemblGenomes-Tr:CAB12546" /db_xref="GOA:O06486" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR013446" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12979" /db_xref="UniProtKB/Swiss-Prot:O06486" /translation="MKAVILCGGKGTRMSEVTNDIPKPLAMIGGKPILWHIMKIYQYY GVNEFILLLGYKGEKIKEYFLDYEWKHNSLTLDSSTGEVQMLGQPETWKITFLETGVD TLTAGRILQAKDYIGDETFLLTYGDGLANINLFHLISYHQTKGAAATVTGIDKVSQFG TLTVEDGMAKTFSEKTSSDGIINGGFFVLSPKVFDYLPKDGNTMFEDEPLKNLAKDGE LAVYRHYGFWTAIDTYKNLLEVNKMWNQGQQVWKVW*" /label="spmH CDS" gene 722694..723458 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /label="spmH gene" CDS 723465..724433 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CDP-sugar-dehydratase/epimerase" /protein_id="NP_388609.2" /db_xref="EnsemblGenomes-Gn:BSU07280" /db_xref="EnsemblGenomes-Tr:CAB12547" /db_xref="GOA:O06485" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12978" /db_xref="UniProtKB/Swiss-Prot:O06485" /translation="MSFWKNKNVFVTGCTGLLGSYLVKELIEQGANVTGLVRDHVPQS NLYQGEHIKKMNIVRGSLEDLAVIERALGEYEIDTVFHLAAQAIVGVANRNPISTFEA NILGTWNILEACRKHPLIKRVIVASSDKAYGDQENLPYDENMPLQGKHPYDVSKSCAD LISHTYFHTYGLPVCITRCGNLYGGGDLNFNRIIPQTIQLVLNGEAPEIRSDGTFVRD YFYIEDAVQAYLLLAEKMEENNLAGEAFNFSNEIQLTVLELVEKILKKMNSNLKPKVL NQGSNEIKHQYLSAEKARKLLNWTPAYTIDEGLEKTIEWYTEFFKK*" /label="spmG CDS" gene 723465..724433 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /label="spmG gene" CDS 724457..725368 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388610.1" /db_xref="EnsemblGenomes-Gn:BSU07290" /db_xref="EnsemblGenomes-Tr:CAB12548" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12977" /db_xref="UniProtKB/Swiss-Prot:O06484" /translation="MTSAYCTVLSKGRLYQAVALFKSLEQVDQDSPIFILCMDEDTHR VLQKLKMKQLNLVPVAALENELLLKLKETRDQSEYCWTMKPIFLQAVLNSNPELERVT YIDGDLFFYADPSPIFENQPDCSVLLSRGDIVIPSFEKEQIDMLQRLLGRYNSGFISF KHDDAGTDCLEWWKERCLEECKNAPGEGKFGDQGYLDYMSELFPNVCDITTPGVNIGH WNYGQHTFSWKDGRIVLEDGSPLIFYHFSGYRIVSINEIKQIHETTRTDLPFVHELYQ ETLPHIIQHMQTLDPEFNGFASKDDNK*" /label="yfnF CDS" gene 724457..725368 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /label="yfnF gene" promotor_-35 725246..725255 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 725268..725287 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 725271 /Source="Nicolas_upshifts" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" CDS 725397..726575 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388611.1" /db_xref="EnsemblGenomes-Gn:BSU07300" /db_xref="EnsemblGenomes-Tr:CAB12549" /db_xref="GOA:O06483" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12976" /db_xref="UniProtKB/Swiss-Prot:O06483" /translation="MKASVIIPAYNSKERLYNSLLSLNQQECDEEFEVIVADNGSEDG TLSMLESFQADFPLIFTRIKENRGIAYGRNQALRNARGDILIFHDSDMLAAKDLVAKH IKAHENEENLVVCGLFWKRIYSFYYERFEEEHKEQLAKLTGEMPKKDKQKLLEEADIK NGSFLDKSFDLDTDFIDVLKKILDEYGDDLKGYHMPWRFFITNNSSVKRKHVVDLGLF DEGIVRYGFEDYDLGIRLHQAGLTFRLRRDIVSVHQEHPSNCKSVDDIRANIAYMCDK YNNIRSLDVHLAFNGPFPPDMTNRIMADIQKLLESQKYDMLLNLFLELLHVVKERNID PDWRKKSPRVTAKSFDLQTVRKLLPKAKKKLGVNDFANALYALVNDLLHVDLRSLDVV *" /label="yfnE CDS" gene 725397..726575 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /label="yfnE gene" promotor_-35 726116..726122 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 726137..726156 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 726151 /Source="Nicolas_upshifts" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 726576..727511 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388612.1" /db_xref="EnsemblGenomes-Gn:BSU07310" /db_xref="EnsemblGenomes-Tr:CAB12550" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12975" /db_xref="UniProtKB/Swiss-Prot:O31542" /translation="MSTFHFSTIVSRTHIFKLMPMIHSLHEHCDDFHLYVLCVDQKAY ELLQHVPWEHVTFVQLHEMEDPELLKAKSNRTFHEYCWTLKPAFLFHVMSKWDDAEYF AHMDTDLFFFSDPARIFAENPTASLYLTDHRNSPRFMSYYDRTGRFNTGFVGAGNTKE AYEAVWQWRQDCIEFCTVEMDTERKTYGDQRYVEKWPEQFKGVHVVKSIGANTALWNI ENYKVGQKDGRVYIDETPLIFYHFSGFTLVTEKEFNLCWYYRIEDEATIKMIYMPYIL NLKRWIDEIQSAFPDFADGFIPKHAVPDTHFIQLD*" /label="yfnD CDS" gene 726576..727511 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /label="yfnD gene" downshifts 727383 /Source="Nicolas_upshifts" /id="D359" /incds=1 /nref=1 /ntot=52 /MaxReadThrough="5.41459" /MaxDrop="2.6465" /score="34.8532284" /energy="-15.2" /TU="U549,U550" /idTUdmin="U549" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 727493 /Source="Nicolas_upshifts" /id="D360" /incds=0 /nref=2 /ntot=30 /MaxReadThrough="2.32849" /MaxDrop="5.65066" /score="34.8532284" /energy="-15.2" /TU="NA" /idTUdmin="U549" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(727534) /Source="Nicolas_upshifts" /id="D361" /incds=0 /nref=158 /ntot=249 /MaxReadThrough="1.15199" /MaxDrop="4.97014" /score="32.9697757" /energy="-15.2" /TU="NA" /idTUdmin="U552" /TUdmin=13 /isTUend="TRUE" /label="downshifts" CDS complement(727542..728771) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388613.1" /db_xref="EnsemblGenomes-Gn:BSU07320" /db_xref="EnsemblGenomes-Tr:CAB12551" /db_xref="GOA:O06481" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12974" /db_xref="UniProtKB/Swiss-Prot:O06481" /translation="MAIAAPLKEKTVQKPGTTVYPILIIIGICHMLNDSLQAVIPAMF PILERSMSLTFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPVGLTASMLGILG LAFAPSFITILCCVFFIGLGSAIFHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMA PLITALILVPLGQFGAVWFTLVAALAVMFLMYIAKWYASRLGSLAQKSGKQKKTAENT AITKSVVSALIIIIFLIFARSWYTSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGA IGTFLGGPLADRFGKRFVILGSLLCSAPLAIVLPFAGPVLAYGVLALIGLVLMSSFSV TVVYAQELVPGKIGTMSGLTVGLAFGMGAIGAVALGALIDAAGLTPTMIAIAFLPVLG ILAFLLPSDQKLREWHS*" /label="yfnC CDS" gene complement(727542..728771) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /label="yfnC gene" promotor_-10 complement(728800..728819) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(728818) /Source="Nicolas_upshifts" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(728835..728842) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(728882..729589) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine nucleotide phosphatase (promiscuous)" /protein_id="NP_388614.1" /db_xref="EnsemblGenomes-Gn:BSU07330" /db_xref="EnsemblGenomes-Tr:CAB12552" /db_xref="GOA:O06480" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR011951" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3ED5" /db_xref="PDB:3I76" /db_xref="SubtiList:BG12973" /db_xref="UniProtKB/Swiss-Prot:O06480" /translation="MKRYRTLLFDVDDTILDFQAAEALALRLLFEDQNIPLTNDMKAQ YKTINQGLWRAFEEGKMTRDEVVNTRFSALLKEYGYEADGALLEQKYRRFLEEGHQLI DGAFDLISNLQQQFDLYIVTNGVSHTQYKRLRDSGLFPFFKDIFVSEDTGFQKPMKEY FNYVFERIPQFSAEHTLIIGDSLTADIKGGQLAGLDTCWMNPDMKPNVPEIIPTYEIR KLEELYHILNIENTVSC*" /label="pynN CDS" gene complement(728882..729589) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /label="pynN gene" downshifts complement(728911) /Source="Nicolas_upshifts" /id="D362" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="2.75071" /MaxDrop="4.28644" /score="1.09492978" /energy="-15.7" /TU="NA" /idTUdmin="U553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(729612..729631) /Source="Nicolas_upshift_promotors" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(729635) /Source="Nicolas_upshifts" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(729681..731066) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12022921, 15849754, 16850406, 17114254, 18632116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 15849754, 16850406, 17114254, 18632116; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methylthioribose permease" /protein_id="NP_388615.1" /db_xref="EnsemblGenomes-Gn:BSU07340" /db_xref="EnsemblGenomes-Tr:CAB12553" /db_xref="GOA:Q797A7" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12972" /db_xref="UniProtKB/Swiss-Prot:Q797A7" /translation="MSSLFRKKPLETLSAQSKSKSLARTLSAFDLTLLGIGCVIGTGI FVITGTVAATGAGPALIISFILAGLACALAAFCYAEFSSSIPISGSVYSYSYVTLGEL LAFLIGWDLMLEYVIALSAVATGWSSYFQSLLAGFNLHIPAALTGAPGSMAGAVFNLP AAVIILLITAIVSRGVKESTRFNNVIVLMKIAIILLFIIVGIGYVKPDNWSPFMPFGM KGVILSAATVFFAYLGFDAVSNASEEVKNPQKNMPVGIISALAVCTVLYIAVSLVLTG MMPYAKLNVGDPVSFALKFVGQDAVAGIISVGAIIGITTVMLALLYAQVRLTFAMSRD GLLPGLFAKVHPSFKTPFRNTWLTGIVAAGIAGFINLGTLAHLVNMGTLAAFTVISIA VIVLRKKHPEIKASFRVPFVPVVPIISAGICLWFMYSLPGVTWLSFVIWIAVGTLVYF LYSRKHSLLNK*" /label="mtrA CDS" gene complement(729681..731066) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /label="mtrA gene" downshifts complement(729703) /Source="Nicolas_upshifts" /id="D363" /incds=0 /nref=8 /ntot=91 /MaxReadThrough="3.68565" /MaxDrop="4.73728" /score="31.1617384" /energy="-15.4" /TU="U554" /idTUdmin="U554" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(731115..731134) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(731132) /Source="Nicolas_upshifts" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(731149..731156) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 731234..731241 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 731249 /Source="Nicolas_upshifts" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 731255..731273 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 731316..732773 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /EC_number="1.2.1.67" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15033535, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vanillin dehydrogenase" /protein_id="NP_388616.1" /db_xref="EnsemblGenomes-Gn:BSU07350" /db_xref="EnsemblGenomes-Tr:CAB12554" /db_xref="GOA:O06478" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12971" /db_xref="UniProtKB/Swiss-Prot:O06478" /translation="MFQYEELNKQFIGGKWQEGSSPNVLENKNPYTQKTFTTFRKATA DDVDEAYRAAALAKKKWDAVNPFEKRTILEKAVTYIEENEEAIIYLIMEELGGTRLKA AFEIGLVKNIIKEAATFPIRMEGKILPSTIDGKENRLYRVPAGVVGVISPFNFPFFLS MKSVAPALGAGNGVVLKPHEETPICGGTLIAKIFENAGIPAGLLNVVVTDIAEIGDSF VEHPVPRIISFTGSTKVGSYIGQLAMKHFKKPLLELGGNSAFIVLEDADIEYAVNAAV FSRFTHQGQICMSANRVLVHSSIYDKFLELYQAKVESLKVGDPMDPDTIIGPLINSRQ TDGLMKTVEQAIEEGAVPVKLGGFNGTIVEPTILKDVKPFMSIAKEELFGPVVSFMKF DSEDEAVDIANETPFGLSGAVHTSNLERGVAFAKRIETGMIHVNDTTINDEPNVAFGG EKQSGLGRLNGEWSLEEFTTLKWISVQHEKRSFPY*" /label="vdhT CDS" gene 731316..732773 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /label="vdhT gene" promotor_-10 complement(732109..732128) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(732123) /Source="Nicolas_upshifts" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(732141..732150) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 732787..733647 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotaxis sensory transducer (sensed target unknown)" /protein_id="NP_388617.1" /db_xref="EnsemblGenomes-Gn:BSU07360" /db_xref="EnsemblGenomes-Tr:CAB12555" /db_xref="GOA:O06477" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="SubtiList:BG12970" /db_xref="UniProtKB/Swiss-Prot:O06477" /translation="MELTINTEKETADILDAFIKVAPYLNSLVQDDITIGIYDTEKLL VNIPAKTFSLNVKAGDPLQEGDIITDAIRSNQKKTSMVPKELFGFPLIARAIPLHDEN GRVIGGVGLGTSLEESSKLHDVAESLSAVVEQTAAAISDISESINGFSTQMSGISSQA KKVSESAGEIADISVTVKGISDQSNLLGLNAAIEAARAGESGKGFSVVADEIRKLATH SKENVGQIDQITKKIHSLLKGLEESIESINQHTDGQAAAVEQISATMQEISGSAQHLA KMAEKALEEE*" /label="yfmS CDS" gene 732787..733647 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /label="yfmS gene" downshifts 733631 /Source="Nicolas_upshifts" /id="D364" /incds=0 /nref=208 /ntot=237 /MaxReadThrough="2.9987" /MaxDrop="6.02377" /score="31.9989755" /energy="-16.7" /TU="U555" /idTUdmin="U555" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 733715..733722 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 733736..733755 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 733741 /Source="Nicolas_upshifts" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="upshifts" CDS 733782..735671 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /EC_number="3.6.3.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10715006, 16109936, 18848624, 19948254, 24389465, 24389466; Product type r : regulator" /codon_start=1 /transl_table=11 /product="putative energy-dependent translational throttleA" /protein_id="NP_388618.1" /db_xref="EnsemblGenomes-Gn:BSU07370" /db_xref="EnsemblGenomes-Tr:CAB12556" /db_xref="GOA:O06476" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12969" /db_xref="UniProtKB/Swiss-Prot:O06476" /translation="MSILKAENLYKTYGDKTLFDHISFHIEENERIGLIGPNGTGKST LLKVIAGLESIEEGEITKSGSVQVEFLHQDPELPAGQTVLEHIYSGESAVMKTLREYE KALYELGKDPENEQRQKHLLAAQAKMDANNAWDANTLAKTVLSKLGVNDVTKPVNELS GGQKKRVAIAKNLIQPADLLILDEPTNHLDNETIEWLEGYLSQYPGAVMLVTHDRYFL NRVTNRIYELERGSLYTYKGNYEVFLEKRAEREAQAEQKETKRQNLLRRELAWLRRGA KARSTKQKARIDRVETLKEQTGPQSSGSLDFAIGSHRLGKQVIEAENVMIAYDGRMLV DRFNELVIPGERIGIIGPNGIGKTTLLNALAGRHTPDGGDITIGQTVRIGYYTQDHSE MNGELKVIDYIKETAEVVKTADGDMITAEQMLERFLFPRSMQQTYIRKLSGGEKRRLY LLQVLMQEPNVLFLDEPTNDLDTETLSVLEDYIDQFPGVVITVSHDRYFLDRVVDRLI VFEGNGVISRFQGSYSDYMEESKAKKAAPKPAAEEKTAEAEPKKKRKKLSYKDQLEWD GIEDKIAQLEEKHEQLEADIAAAGSDFGKIQELMAEQAKTAEELEAAMDRWTELSLMI EELES*" /label="ettA CDS" gene 733782..735671 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /label="ettA gene" downshifts 735655 /Source="Nicolas_upshifts" /id="D365" /incds=0 /nref=2 /ntot=134 /MaxReadThrough="2.98669" /MaxDrop="2.72484" /score="30.3267801" /energy="-13.8" /TU="U557" /idTUdmin="U557" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" misc_feature 735735..735754 /Source="Nicolas_upshift_promotors" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 735743 /Source="Nicolas_upshifts" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="upshifts" CDS 735794..736240 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26483775" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388619.1" /db_xref="EnsemblGenomes-Gn:BSU07380" /db_xref="EnsemblGenomes-Tr:CAB12557" /db_xref="GOA:O06475" /db_xref="InterPro:IPR019723" /db_xref="SubtiList:BG12968" /db_xref="UniProtKB/Swiss-Prot:O06475" /translation="MTWAIVMLILMSLVKIVLTCLPTGVIEWLLGKFEVHAKLSDENA SLSLDGKRLEGAEKQKVIDQFNEAIFLEKYYIYPGDEERYLHPENGGTPLVIDTKKGK KDVKLFVYRYDDHIDVVKQYKKKVIAYRVLSESLQKESLSVAGSLA*" /label="yfmQ CDS" gene 735794..736240 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /label="yfmQ gene" downshifts complement(735796) /Source="Nicolas_upshifts" /id="D366" /incds=0 /nref=48 /ntot=154 /MaxReadThrough="1.16717" /MaxDrop="4.57866" /score="0.689181271" /energy="-10.2" /TU="NA" /idTUdmin="U559" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(735880..735883) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(735885) /Source="Nicolas_upshifts" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(735901..735902) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 736227 /Source="Nicolas_upshifts" /id="D367" /incds=0 /nref=254 /ntot=267 /MaxReadThrough="3.12706" /MaxDrop="7.87026" /score="13.6774886" /energy="-8" /TU="U558" /idTUdmin="U557" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 736303..736310 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 736324..736343 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 736336 /Source="Nicolas_upshifts" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="upshifts" CDS 736365..736787 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family) of metal(copper) efflux transporter expression" /protein_id="NP_388620.1" /db_xref="EnsemblGenomes-Gn:BSU07390" /db_xref="EnsemblGenomes-Tr:CAB12558" /db_xref="GOA:O06474" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG12967" /db_xref="UniProtKB/Swiss-Prot:O06474" /translation="MEWMKIDQVAKRSGLTKRTIRFYEEIGLIPAPKRTDGGVRLYSE DDMEELEKVISTKEVLGFSLQELQHFMETSRQLELNKEGYLLSLDPKERKEKLEEIQE TLNHQLDLIDEKIRTFQSFKERLQGMKGKAERAIQSIE*" /label="copP CDS" gene 736365..736787 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /label="copP gene" downshifts 736623 /Source="Nicolas_upshifts" /id="D368" /incds=1 /nref=2 /ntot=135 /MaxReadThrough="4.24358" /MaxDrop="2.69696" /score="13.6774886" /energy="-8" /TU="U560" /idTUdmin="U558" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS 736853..738043 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14663075, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="metal (copper) efflux transporter" /protein_id="NP_388621.1" /db_xref="EnsemblGenomes-Gn:BSU07400" /db_xref="EnsemblGenomes-Tr:CAB12559" /db_xref="GOA:O06473" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12966" /db_xref="UniProtKB/Swiss-Prot:O06473" /translation="MDKTTQVNQKTGLLSQPKAVWAVAFACVISFMGIGLVDPILPAI AAQLHASPSEVSLLFTSYLLVTGFMMFFSGAISSRIGAKWTLILGLIFIIVFAGLGGS SSSIAQLVGYRGGWGLGNALFISTALAVIVGVSVGGSAQAIILYEAALGLGISVGPLA GGELGSISWRAPFFGVSVLMFIALIAISFMLPKLPKPAKRVGVFDAMKALKYKGLLTM AVSAFLYNFGFFILLAYSPFVLDLDEHGLGYVFFGWGLLLAITSVFTAPLVHKALGTV RSLVVLFIAFAAILVIMGIWTDHQTLIITCIVVAGAVLGMVNTIMTTAVMGSAPVERS IASSAYSSVRFIGGALAPWIAGMLSEHFTASTPYTVGGIVVFVGMLVLLMGRKHLAGI KAGH*" /label="copO CDS" gene 736853..738043 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /label="copO gene" downshifts complement(738107) /Source="Nicolas_upshifts" /id="D369" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="-0.0437700000000003" /MaxDrop="2.92105" /score="-8.93016606" /energy="-11.6" /TU="NA" /idTUdmin="U562" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS 738334..738489 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388622.1" /db_xref="EnsemblGenomes-Gn:BSU07410" /db_xref="EnsemblGenomes-Tr:CAB12560" /db_xref="SubtiList:BG12965" /db_xref="UniProtKB/Swiss-Prot:O06472" /translation="MDKAKPDEYDQKCLETLYQYIHSVMKNSFSRSSGLPLGKMRRIL SCLPKES*" /label="yfmN CDS" gene 738334..738489 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /label="yfmN gene" CDS complement(738609..740165) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /EC_number="3.6.3.-" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 16109936, 16684363, 22333191, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388623.2" /db_xref="EnsemblGenomes-Gn:BSU07420" /db_xref="EnsemblGenomes-Tr:CAB12571" /db_xref="GOA:O34512" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12964" /db_xref="UniProtKB/Swiss-Prot:O34512" /translation="MSILSVKDLSHGFGDRAIFNNVSFRLLKGEHVGLIGANGEGKST FMNIITGKLEPDEGKVEWSKNVRVGYLDQHTVLEKGKSIRDVLKDAFHYLFAMEEEMN EIYNKMGEADPDELEKLLEEVGVIQDALTNNDFYVIDSKVEEIARGLGLSDIGLERDV TDLSGGQRTKVLLAKLLLEKPEILLLDEPTNYLDEQHIEWLKRYLQEYENAFILISHD IPFLNSVINLIYHVENQELTRYVGDYHQFMEVYEVKKQQLEAAYKKQQQEVAELKDFV ARNKARVSTRNMAMSRQKKLDKMDMIELAAEKPKPEFHFKPARTSGKLIFETKDLVIG YDSPLSRPLNLRMERGQKIALYGANGIGKTTLLKSLLGEIQPLEGSVERGEHIYTGYF EQEVKETNNNTCIEEVWSEFPSYTQYEIRAALAKCGLTTKHIESRVSVLSGGEKAKVR LCKLINSETNLLVLDEPTNHLDADAKEELKRALKEYKGSILLISHEPDFYMDIATETW NCESWTTKVL*" /label="ettM CDS" gene complement(738609..740165) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /label="ettM gene" downshifts complement(738633) /Source="Nicolas_upshifts" /id="D370" /incds=0 /nref=173 /ntot=264 /MaxReadThrough="0.35675" /MaxDrop="5.82627" /score="21.7805812" /energy="-12" /TU="NA" /idTUdmin="U562" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 739995..740001 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 740016..740027 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 740033 /Source="Nicolas_upshifts" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(740215..740234) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(740219) /Source="Nicolas_upshifts" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(740250..740254) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 740275..740278 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 740294..740313 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 740297 /Source="Nicolas_upshifts" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" CDS 740338..741468 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11976317; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_388624.1" /db_xref="EnsemblGenomes-Gn:BSU07430" /db_xref="EnsemblGenomes-Tr:CAB12572" /db_xref="GOA:O34750" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12963" /db_xref="UniProtKB/Swiss-Prot:O34750" /translation="MTQTWPFLHNAQSFIQENWNASGFQKPTPVQEQAAQLIMDGKDV IAESPTGTGKTLAYALPVLERIKPEQKHPQAVILAPSRELVMQIFQVIQDWKAGSELR AASLIGGANVKKQVEKLKKHPHIIVGTPGRVFELIKAKKLKMHEVKTIVLDETDQLVL PEHRETMKQIIKTTLRDRQLLCFSATLKKETEDVLRELAQEPEVLKVQRSKAEAGKVK HQYLICDQRDKVKLLQKLSRLEGMQALVFVRDIGNLSVYAEKLAYHHVELGVLHSEAK KMERAKIIATFEDGEFPLLLATDIAARGLDIENLPYVIHADIPDEDGYVHRSGRTGRA GKEGNVLSLVTKLEESKLKKMAKKLGVELSEAVYAGGKLKTK*" /label="yfmL CDS" gene 740338..741468 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /label="yfmL gene" downshifts 741451 /Source="Nicolas_upshifts" /id="D371" /incds=0 /nref=43 /ntot=133 /MaxReadThrough="2.93747" /MaxDrop="4.41385" /score="23.4253604" /energy="-5.9" /TU="NA" /idTUdmin="U563" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS 741536..741982 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388625.1" /db_xref="EnsemblGenomes-Gn:BSU07440" /db_xref="EnsemblGenomes-Tr:CAB12573" /db_xref="GOA:O34536" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12962" /db_xref="UniProtKB/Swiss-Prot:O34536" /translation="MASIDRFQVMQEPELKILEHWFENEDTRRRMDGMLLLDEWYARV NKDKHDTVIMAYDGQLPAGMVVIEFGEERTYIGLIVNPLYRLKGYGKQILQKLMTEPD FTSVREWVACIEEDNRISLACFQAAGFTLEDTEPDEDGFLTLILRN*" /label="yfmK CDS" gene 741536..741982 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /label="yfmK gene" CDS complement(742035..743054) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388626.1" /db_xref="EnsemblGenomes-Gn:BSU07450" /db_xref="EnsemblGenomes-Tr:CAB12574" /db_xref="GOA:O34812" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12961" /db_xref="UniProtKB/Swiss-Prot:O34812" /translation="MTASQQQIQLARRPQGIPVHEDFRFETIPVPEPKQGEVLVKTLY VSVDPYMRGRMQDTKSYVEPFALDKALSGGVIAEVVSDGNHLKKGDIVIGNLSWQEFS AVSESALRKIDTSLAPASAYLGILGMTGLTAYFGLLDIGRPKEGETVVVSGAAGAVGS TVGQIAKIKGARVVGIAGSDEKIDYLKQELQFDEAINYKTADDIQKALQNACPDGVDV YFDNVGGPISDAVMNLLNEFARIPVCGAISSYNAESEADDMGPRVQSKLIKTKSLMQG FIVSDYSDRFSEGAKQLAEWLKAGKLHYEETITEGFENIPDAFLGLFKGENKGKQLIK VSDPS*" /label="yfmJ CDS" gene complement(742035..743054) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /label="yfmJ gene" downshifts complement(742045) /Source="Nicolas_upshifts" /id="D372" /incds=0 /nref=183 /ntot=252 /MaxReadThrough="2.26899" /MaxDrop="5.73395" /score="20.8047206" /energy="-12.8" /TU="NA" /idTUdmin="U564" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(743075..743094) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(743079) /Source="Nicolas_upshifts" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(743081..743535) /Source="Nicolas_S_feature" /locus_tag="new_818856_819310_c" /HighExp="S2, S1, Pyr, T4.0H, T0.0H, T-2.40H, T3.30H, T-1.40H, T-0.40H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S252" promotor_-35 complement(743107..743114) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 743173..743180 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 743194..743213 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 743201..744298 /Source="Nicolas_S_feature" /locus_tag="new_818976_820073" /HighExp="Etha, dia5, Diami, C30, dia15, T5.0H, S8, T3.0H, M0t90, LPhT" /AntisenseName="yfmI" /AntisenseCor="0.135213889213362" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S253" upshifts 743201 /Source="Nicolas_upshifts" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="upshifts" CDS complement(743536..744756) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388627.1" /db_xref="EnsemblGenomes-Gn:BSU07460" /db_xref="EnsemblGenomes-Tr:CAB12575" /db_xref="GOA:O34440" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12960" /db_xref="UniProtKB/Swiss-Prot:O34440" /translation="MSKGYYSILFSQTTTNLGFSLYTMVVISFLFKMTNSTTIASMVT LISIIFRIFGSAILPLITIRLKLPLTIIISQLIQMLLLICLFYALLRTYSNQTLILVF IIISCISFFNGWFSPLKSAIIGEIISPDRRVKANGLLSTVDQTFQFVGWSLGGLIIAF LGEGYTIILTIFLLFTSLLSLLFCLPHGHANSVIREKNSPNKSIVSGWRYLFSQKKLR TIIIMDLIESWAGMIWIGSVSLAFVNEVLHKGESWWGFINGAYYLGSMIGGFIIYKLS ERFQNKLINFMLIGAVSYGSLTLIYGFISNSYLALILVLFMGPAYILRDLTQETLIQN ITTEQTRINIMSARSSLVQFIFMFSILAIGAISDFLGVRLVYVSAGILLLVSAIYGFS QLQFKKKVNKHISF*" /label="yfmI CDS" gene complement(743536..744756) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /label="yfmI gene" promotor_-10 complement(744793..744812) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(744800) /Source="Nicolas_upshifts" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(744828..744835) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 744854..744861 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 744873..745048 /Source="Nicolas_S_feature" /locus_tag="new_820648_820823" /HighExp="LoTm, T-1.10H, T-0.40H, S3, M9-stat, T0.0H, T-1.40H, BC, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.98260400000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S254" upshifts 744873 /Source="Nicolas_upshifts" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 744876..744895 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 745005 /Source="Nicolas_upshifts" /id="D373" /incds=0 /nref=34 /ntot=117 /MaxReadThrough="8.67835" /MaxDrop="8.45742" /score="4.02328636" /energy="-13.7" /TU="U567" /idTUdmin="U565" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 745092..746555 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388629.1" /db_xref="EnsemblGenomes-Gn:BSU07480" /db_xref="EnsemblGenomes-Tr:CAB12577" /db_xref="InterPro:IPR005532" /db_xref="InterPro:IPR016187" /db_xref="SubtiList:BG12958" /db_xref="UniProtKB/Swiss-Prot:O34722" /translation="MTLLMQDHKSIYNKDIEILIEVEELITSVPENKKNDFKSLIDNR IMTLLNKIQHPVAAENVFGMCIAYPNTYIRYRLIDFVEKWVPYFSAVETIINLTQDPD DLVSFKAMDVCANHKIEESVAYLSSIIDDVRESISYPKKPVGLGAQKVLSTLLDIFGV EKHEELVMLKNYFDQNGILPNNFDFEEKIPQSLIEEFEKTEEDGMILIPGGFFEFGLN ENEIPDKTFNWKDAVPRQKVWLPPFFIDKYPVTNKDYDIFTEFIEENGHIFCHPNEPQ NKQHRRNTYWDDRYLDNHPVTGIDFYDAFAYARYKGKELPTEFQWEKAARGEKGNVWP WGDKFDPAKVQYAGSLYNEPITSLKSWRENLLKAHADKELNHLTSDIFEQNGESPYGV CGMIGGTWEWTRSELKTKRAFHPIFENVPFNSVNSFAVLKGGSFFSHPGLMFPSFRAK DIPFCRHNEMGIRCVKNIPVYKIRESINGPITNKAIY*" /label="yfmG CDS" gene 745092..746555 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /label="yfmG gene" S_feature complement(745457..747127) /Source="Nicolas_S_feature" /locus_tag="new_821232_822902_c" /HighExp="H2O2, C30, Salt, Lbstat, dia15, LPhT, dia5, Paraq, HiOs, Diami" /AntisenseName="yfmG" /AntisenseCor="-0.58045119682782798" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S255" S_feature 746556..747049 /Source="Nicolas_S_feature" /locus_tag="new_822331_822824" /HighExp="LoTm, T0.0H, T-1.40H, T-0.40H, T-2.40H, T-1.10H, Pyr, T-3.40H, SMMPr, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S256" promotor_-35 747037..747042 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 747051..750316 /Source="Nicolas_S_feature" /locus_tag="new_822826_826091" /HighExp="LoTm, Pyr, B36, T3.30H, T2.0H, T-0.40H, T2.30H, B60, T4.0H, T3.0H" /AntisenseName="yfmE" /AntisenseCor="-0.61640022790163695" /AntisenseRegPval="-28.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S257" upshifts 747051 /Source="Nicolas_upshifts" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 747058..747076 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(747128..747928) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16672620, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (ATP-binding protein)" /protein_id="NP_388630.1" /db_xref="EnsemblGenomes-Gn:BSU07490" /db_xref="EnsemblGenomes-Tr:CAB12578" /db_xref="GOA:O34510" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12957" /db_xref="UniProtKB/Swiss-Prot:O34510" /translation="MGKLAADQLTLSYDSTVIIDGVDLKIEEGKITALIGANGCGKST ILKSLARLMAPKSGTVLLEGKDIHRQPSKEVAKKLAILPQSPQAPEGLTVEELCYFGR HPHKKLLSKHTQEDHDMVEWALEATGMIELKDRTLDALSGGQRQRAWISMALAQGTDL LLLDEPTTYLDISHQIEVLELLKKLNRDHGRTVVMVLHDLNQAAQYADYLISVLDGKI YNAGTPEDVFTQPFFREVFGLECCIMRSPIDQKPMCLPTGLCPKLRAK*" /label="fecF CDS" gene complement(747128..747928) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /label="fecF gene" CDS complement(747941..748942) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16672620, 16850406, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388631.1" /db_xref="EnsemblGenomes-Gn:BSU07500" /db_xref="EnsemblGenomes-Tr:CAB12579" /db_xref="GOA:O34832" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12956" /db_xref="UniProtKB/Swiss-Prot:O34832" /translation="MKKTTRKQKRPLLAILILAVILIVLSVISIGIGALYISPDAVVT NLLGLDHSFEFIIQQYRLPRIILAILAGAGLAAAGAILQGVIRNPLASPDVVGISKGS GLAAMAVILIFPESPVYVLPFSAFAGAAIIAVLLLMIARKKSIQPSSLALSGIALGAV CHAGMQYMMVKFPGDVNAALIWLTGSLWGRNWEEVKLLAPWLLILFPIVCILIPKLDL MSLGDELAQGLGENANRLRFILIFTAVALAGSCVAVVGSIGFIGLLAPHIARRLTGEK AKYLLPASALIGAIILLIADTLGRGIMPPVEIPAGILTAVIGAPYFLYLLKFEARKQ* " /label="fecE CDS" gene complement(747941..748942) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /label="fecE gene" promotor_-10 complement(748528..748547) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(748540) /Source="Nicolas_upshifts" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(748562..748569) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(748939..749940) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388632.1" /db_xref="EnsemblGenomes-Gn:BSU07510" /db_xref="EnsemblGenomes-Tr:CAB12580" /db_xref="GOA:O34933" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12955" /db_xref="UniProtKB/Swiss-Prot:O34933" /translation="MYHSAKRRSSSRLMMFIIALIIFIFGLGLNLSVGASDISIIDSL KYLFVWDGSKEQLIISTLRLPRTLIGVFVGASLAVAGALMQAMTRNPLASPQIFGVNA GASLFVVASLVILPASPYSSVIFAFAGAAAGGAIVYMIASSGGMTPVKLALSGMAVHL FLSSMTQAIIILNESGEDVLYWMTGAIDGSNWQDVITIAPFSVIGIGLALVFSGSVSV LGLGDETAKGLGQNMNGIRILISLIILILSGASVAVAGPIGFVGLLVPHIVRKLIGEH YQYVLPFSALFGAILLVYADVLARWIAFPYESPVGIVTAIIGTPFFLYLARKGRNLK* " /label="fecD CDS" gene complement(748939..749940) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /label="fecD gene" misc_feature complement(750010..750029) /Source="Nicolas_upshift_promotors" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(750012..750959) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (binding lipoprotein)" /protein_id="NP_388633.1" /db_xref="EnsemblGenomes-Gn:BSU07520" /db_xref="EnsemblGenomes-Tr:CAB12581" /db_xref="GOA:O34348" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12954" /db_xref="UniProtKB/Swiss-Prot:O34348" /translation="MRTYSNKLIAIMSVLLLACLIVSGCSSSQNNNGSGKSESKDSRV IHDEEGKTTVSGTPKRVVVLELSFLDAVHNLGITPVGIADDNKKDMIKKLVGSSIDYT SVGTRSEPNLEVISSLKPDLIIADAERHKNIYKQLKKIAPTIELKSREATYDETIDSF TTIAKALNKEDEGKEKLAEHKKVINDLKAELPKDENRNIVLGVARADSFQLHTSSSYD GEIFKMLGFTHAVKSDNAYQEVSLEQLSKIDPDILFISANEGKTIVDEWKTNPLWKNL KAVKNGQVYDADRDTWTRFRGIKSSETSAKDVLKKVYNK*" /label="fecC CDS" gene complement(750012..750959) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /label="fecC gene" downshifts complement(750031) /Source="Nicolas_upshifts" /id="D374" /incds=0 /nref=41 /ntot=211 /MaxReadThrough="4.92983" /MaxDrop="4.53674" /score="-3.64310934" /energy="-13.9" /TU="U570,U573,U574" /idTUdmin="U570" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" upshifts complement(750031) /Source="Nicolas_upshifts" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 750286..750291 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 750307..750325 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 750318..750943 /Source="Nicolas_S_feature" /locus_tag="new_826093_826718" /HighExp="LoTm, B36, S5, S6, S4, S7, S8, S3, BT, B60" /AntisenseName="yfmC" /AntisenseCor="-0.52042999587715499" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S258" upshifts 750318 /Source="Nicolas_upshifts" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="upshifts" misc_feature 750939..750958 /Source="Nicolas_upshift_promotors" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 750945..751476 /Source="Nicolas_S_feature" /locus_tag="new_826720_827251" /HighExp="LoTm, B36, S5, S4, S7, S6, S8, B60, S3, BT" /AntisenseName="yfmB" /AntisenseCor="-6.4915194654100006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.997, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S259" upshifts 750945 /Source="Nicolas_upshifts" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(751001..751020) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(751008) /Source="Nicolas_upshifts" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(751034..751041) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(751068..751436) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25651892" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388634.1" /db_xref="EnsemblGenomes-Gn:BSU07530" /db_xref="EnsemblGenomes-Tr:CAB12582" /db_xref="InterPro:IPR021579" /db_xref="PDB:2EUC" /db_xref="SubtiList:BG12953" /db_xref="UniProtKB/Swiss-Prot:O34626" /translation="MQYFSPEQQYNAWIVSDLVKQIFHKRAGCSPGIHELAVFAEEHF HIDIDFVFSIIMNIGDIEFALTDEIEKKLSGYLSTLLPYVTADMFETSKANAHAFLSR RHGNAAYHLFVSDDAFMRKQ*" /label="yfmB CDS" gene complement(751068..751436) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /label="yfmB gene" S_feature complement(751437..751549) /Source="Nicolas_S_feature" /locus_tag="new_827212_827324_c" /HighExp="Etha, BC, Sw, M9-stat, T3.30H, T1.30H, T3.0H, T5.0H, T2.30H, T2.0H" /AntisenseName="yfmA" /AntisenseCor="5.8024036419347599E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S260" promotor_-10 complement(751538..751557) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-10" upshifts complement(751549) /Source="Nicolas_upshifts" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="upshifts" promotor_-35 complement(751569..751576) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-35" promotor_-35 751617..751623 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 751637..751655 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 751637 /Source="Nicolas_upshifts" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 751680..752027 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12089032; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heat stress induced protein" /protein_id="NP_388636.1" /db_xref="EnsemblGenomes-Gn:BSU07550" /db_xref="EnsemblGenomes-Tr:CAB12584" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG19020" /db_xref="UniProtKB/Swiss-Prot:P80241" /translation="MKPVVKEYTNDEQLMKDVEELQKMGVAKEDVYVLAHDDDRTERL ADNTNANTIGAKETGFKHAVGNIFNKKGDELRNKIHEIGFSEDEAAQFEKRLDEGKVL LFVTDNEKVKAWA*" /label="yflT CDS" gene 751680..752027 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /label="yflT gene" downshifts complement(751681) /Source="Nicolas_upshifts" /id="D375" /incds=0 /nref=6 /ntot=28 /MaxReadThrough="1.00082" /MaxDrop="4.87687" /score="-3.31058364" /energy="-3.6" /TU="NA" /idTUdmin="U570" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" downshifts 752023 /Source="Nicolas_upshifts" /id="D376" /incds=0 /nref=56 /ntot=197 /MaxReadThrough="6.41566" /MaxDrop="7.61596" /score="-1.88723414" /energy="-5.6" /TU="U575" /idTUdmin="U567" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 752068..752148 /Source="Nicolas_S_feature" /locus_tag="new_827843_827923" /HighExp="Etha, Salt, B36, LoTm, Heat, B60, M9-stat, S8, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S261" misc_feature 752149..752168 /Source="Nicolas_upshift_promotors" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 752150 /Source="Nicolas_upshifts" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="upshifts" CDS 752218..753480 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8262178, 12823818, 27447541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8262178, 12823818, 27447541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pectate lyase" /protein_id="NP_388637.1" /db_xref="EnsemblGenomes-Gn:BSU07560" /db_xref="EnsemblGenomes-Tr:CAB12585" /db_xref="GOA:P39116" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="PDB:1BN8" /db_xref="PDB:2BSP" /db_xref="PDB:2NZM" /db_xref="PDB:2O04" /db_xref="PDB:2O0V" /db_xref="PDB:2O0W" /db_xref="PDB:2O17" /db_xref="PDB:2O1D" /db_xref="PDB:3KRG" /db_xref="PDB:5AMV" /db_xref="SubtiList:BG10840" /db_xref="UniProtKB/Swiss-Prot:P39116" /translation="MKKVMLATALFLGLTPAGANAADLGHQTLGSNDGWGAYSTGTTG GSKASSSNVYTVSNRNQLVSALGKETNTTPKIIYIKGTIDMNVDDNLKPLGLNDYKDP EYDLDKYLKAYDPSTWGKKEPSGTQEEARARSQKNQKARVMVDIPANTTIVGSGTNAK VVGGNFQIKSDNVIIRNIEFQDAYDYFPQWDPTDGSSGNWNSQYDNITINGGTHIWID HCTFNDGSRPDSTSPKYYGRKYQHHDGQTDASNGANYITMSYNYYHDHDKSSIFGSSD SKTSDDGKLKITLHHNRYKNIVQRAPRVRFGQVHVYNNYYEGSTSSSSYPFSYAWGIG KSSKIYAQNNVIDVPGLSAAKTISVFSGGTALYDSGTLLNGTQINASAANGLSSSVGW TPSLHGSIDASANVKSNVINQAGAGKLN*" /label="pelA CDS" gene 752218..753480 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /label="pelA gene" downshifts 753475 /Source="Nicolas_upshifts" /id="D377" /incds=0 /nref=139 /ntot=203 /MaxReadThrough="3.61256" /MaxDrop="5.92635" /score="1.82127533" /energy="-8.2" /TU="U575,U576" /idTUdmin="U576" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-35 753533..753536 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 753551..753570 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 753559 /Source="Nicolas_upshifts" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 753607..755043 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12949159, 15849754, 16850406, 25651892, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949159, 15849754, 16850406, 25651892, 28436820; Product type t : transporter" /codon_start=1 /transl_table=11 /product="malate (2-oxoglutarate) transporter" /protein_id="NP_388638.1" /db_xref="EnsemblGenomes-Gn:BSU07570" /db_xref="EnsemblGenomes-Tr:CAB12586" /db_xref="GOA:O34726" /db_xref="InterPro:IPR001898" /db_xref="InterPro:IPR030676" /db_xref="SubtiList:BG12951" /db_xref="UniProtKB/Swiss-Prot:O34726" /translation="MASEKDAGKQSAVKLVPLLITVAVGLIIWFIPAPSGLEPKAWHL FAIFVATIIGFISKPLPMGAIAIFALAVTALTGTLSIEDTLSGFGNKTIWLIVIAFFI SRGFIKTGLGARISYVFVQKFGKKTLGLSYSLLFSDLILSPAIPSNTARAGGIIFPII RSLSETFGSSPANGTERKIGAFLLKTGFQGNLITSAMFLTAMAANPLIAKLAHDVAGV DLTWTSWAIAAIVPGLVSLIITPLVIYKLYPPEIKETPDAAKIATEKLKEMGPFKKSE LSMVIVFLLVLVLWIFGGSFNIDATTTALIGLAVLLLSQVLTWDDIKKEQGAWDTLTW FAALVMLANFLNELGMVSWFSNAMKSSVSGFSWIVAFIILIVVYYYSHYFFASATAHI SAMYSAFLAVVVAAGAPPLLAALSLAFISNLFGSTTHYGSGAAPVFFGAGYIPQGKWW SIGFILSIVHIIVWLVIGGLWWKVLGIW*" /label="maeS CDS" gene 753607..755043 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /label="maeS gene" downshifts 755035 /Source="Nicolas_upshifts" /id="D378" /incds=0 /nref=56 /ntot=132 /MaxReadThrough="2.39993" /MaxDrop="5.36125" /score="40.3051497" /energy="-9.7" /TU="NA" /idTUdmin="U577" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature 755134..755153 /Source="Nicolas_upshift_promotors" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 755145 /Source="Nicolas_upshifts" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="upshifts" CDS 755170..756798 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388639.1" /db_xref="EnsemblGenomes-Gn:BSU07580" /db_xref="EnsemblGenomes-Tr:CAB12587" /db_xref="GOA:O34427" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12576" /db_xref="UniProtKB/Swiss-Prot:O34427" /translation="MVKKRFHFSLQTKIMGLIAALLVFVIGVLTITLAVQHTQGERRQ AEQLAVQTARTISYMPPVKELIERKDGHAAQTQEVIEQMKEQTGAFAIYVLNEKGDIR SASGKSGLKKLERSREILFGGSHVSETKADGRRVIRGSAPIIKEQKGYSQVIGSVSVD FLQTETEQSIKKHLRNLSVIAVLVLLLGFIGAAVLAKSIRKDTLGLEPHEIAALYRER NAMLFAIREGIIATNREGVVTMMNVSAAEMLKLPEPVIHLPIDDVMPGAGLMSVLEKG EMLPNQEVSVNDQVFIINTKVMNQGGQAYGIVVSFREKTELKKLIDTLTEVRKYSEDL RAQTHEFSNKLYAILGLLELGEYDEAIDLIKEEYAIQNEQHDLLFHNIHSQQVQAILL GKISKASEKKVKLVIDENSSLAPLPAHIGLSHLITIIGNLIDNAFEAVAEQSVKEVLF FITDMGHDIVIEVSDTGPGVPPEKIEAVFERGYSSKGMRRGYGLANVKDSVRELGGWI ELANQKTGGAVFTVFIPKEKQRGNPFDSHRDCGG*" /label="citS CDS" gene 755170..756798 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /label="citS gene" CDS 756770..757450 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388640.1" /db_xref="EnsemblGenomes-Gn:BSU07590" /db_xref="EnsemblGenomes-Tr:CAB12588" /db_xref="GOA:O34534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR028141" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12577" /db_xref="UniProtKB/Swiss-Prot:O34534" /translation="MIHIAIAEDDFRVAQIHERLIKQLDGFKIIGKAANAKETLALLK EHKADLLLLDIYMPDELGTALIPDIRSRFPEVDIMIITAATETRHLQEALRAGIAHYL IKPVTADKFRQVLLQYKEKRKLLMSQPEVSQSMIDHIFGNGVKTALPAEDLPTGINSI TLRKIKEALQTASEGLTAEELGEKMGASRTTARRYAEYLVSKEEARAELEYGIIGRPE RKYYLAAD*" /label="citT CDS" gene 756770..757450 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /label="citT gene" CDS 757453..758412 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11029430; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative tricarboxylate transporter component" /protein_id="NP_388641.2" /db_xref="EnsemblGenomes-Gn:BSU07600" /db_xref="EnsemblGenomes-Tr:CAB12589" /db_xref="GOA:O34439" /db_xref="InterPro:IPR005064" /db_xref="SubtiList:BG12950" /db_xref="UniProtKB/Swiss-Prot:O34439" /translation="MKKSIILLNILLIFMQGDIRQAAAPRLPDGPIEIVVPAEPSGGW DVTAQAIQSVLRQKQIVKDDVHIVYKSGGGGEKGWKYVNKSSKQTISMTSSLILSNDL LGQSKLKMSDFTPLAILSKEWQTVALPKGSALTNGKDVLNEINMHPGKVRIGFAPGFG NDDQLSFVRAADMYGIDPFDIQFSQYDSSEQLIQALIRHEIEAASMTLSEAKPYERNG DITLAAVTSDKRLPGFPNVPTWKEQGIPFVFSHWRGILGPKNMSEEEISYWDQALKKV TSSPEWKRKINEQDWESFYLNSRETKRFLEEQSAFYQSIMTGN*" /label="yflP CDS" gene 757453..758412 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /label="yflP gene" downshifts 758381 /Source="Nicolas_upshifts" /id="D379" /incds=0 /nref=76 /ntot=211 /MaxReadThrough="1.1681" /MaxDrop="6.31244" /score="10.4510496" /energy="-6.5" /TU="NA" /idTUdmin="U578" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 758504..758511 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 758524..758543 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 758535..758607 /Source="Nicolas_S_feature" /locus_tag="new_834310_834382" /HighExp="M9-stat, SMMPr, SMM, T0.0H, LoTm, T1.0H, Pyr, T1.30H, Cold, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S262" upshifts 758535 /Source="Nicolas_upshifts" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="upshifts" CDS 758608..759909 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="transporter of divalent metal ions/citrate complexes" /protein_id="NP_388642.1" /db_xref="EnsemblGenomes-Gn:BSU07610" /db_xref="EnsemblGenomes-Tr:CAB12590" /db_xref="GOA:P55069" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11832" /db_xref="UniProtKB/Swiss-Prot:P55069" /translation="MLAILGFLMMLVFMALIMTKRLSVLTALVLTPIVFALIAGFGFT EVGDMMISGIQQVAPTAVMIMFAILYFGIMIDTGLFDPMVGKILSMVKGDPLKIVVGT AVLTMLVALDGDGSTTYMITTSAMLPLYLLLGIRPIILAGIAGVGMGIMNTIPWGGAT PRAASALGVDPAELTGPMIPVIASGMLCMVAVAYVLGKAERKRLGVIELKQPANANEP AAAVEDEWKRPKLWWFNLLLTLSLIGCLVSGKVSLTVLFVIAFCIALIVNYPNLEHQR QRIAAHSSNVLAIGSMIFAAGVFTGILTGTKMVDEMAISLVSMIPEQMGGLIPAIVAL TSGIFTFLMPNDAYFYGVLPILSETAVAYGVDKVEIARASIIGQPIHMLSPLVPSTHL LVGLVGVSIDDHQKFALKWAVLAVIVMTAIALLIGAISISV*" /label="citM CDS" gene 758608..759909 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /label="citM gene" promotor_-35 759906..759912 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 759926..759937 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 759927 /Source="Nicolas_upshifts" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="upshifts" CDS 759965..760759 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10972810, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388643.1" /db_xref="EnsemblGenomes-Gn:BSU07620" /db_xref="EnsemblGenomes-Tr:CAB12591" /db_xref="GOA:O34409" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12949" /db_xref="UniProtKB/Swiss-Prot:O34409" /translation="MSDPYMPLTSVRSGAGFEAAKGVHGLTVQIANVYFIQLPSEPHS FVLIDAGMPQSAGVIVNEAKQRFGEGFQLKAIILTHGHFDHIGAIEEILEHWDVPVYI HSREMPYVTGKEDYPPARPDSKSGLVAKLSPLFPRHSIDISSHVQALPEDGSVPFLDE WMWIATPGHTPGHISLFRDDGRVLVAGDAVITVEQEKMADVLIQKQELHGPPAYFTPD TETAAESILKLAGLEPEALLTGHGIPMTGKNFRSDLTELANRLSSI*" /label="yflN CDS" gene 759965..760759 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /label="yflN gene" downshifts 760735 /Source="Nicolas_upshifts" /id="D380" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="0.0114999999999998" /MaxDrop="3.05232" /score="38.3109333" /energy="-11.8" /TU="NA" /idTUdmin="U580" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-35 760814..760817 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 760832..760851 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 760845 /Source="Nicolas_upshifts" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="upshifts" CDS 760878..761969 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /EC_number="1.14.13.39" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11856757, 12220171, 16172391, 25643072, 25826316, 26062720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11856757, 12220171, 16172391, 25643072, 25826316, 26062720; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitric-oxide synthase" /protein_id="NP_388644.2" /db_xref="EnsemblGenomes-Gn:BSU07630" /db_xref="EnsemblGenomes-Tr:CAB12592" /db_xref="GOA:O34453" /db_xref="InterPro:IPR004030" /db_xref="InterPro:IPR017142" /db_xref="InterPro:IPR036119" /db_xref="PDB:1M7V" /db_xref="PDB:1M7Z" /db_xref="PDB:2AMO" /db_xref="PDB:2AN0" /db_xref="PDB:2AN2" /db_xref="PDB:2FBZ" /db_xref="PDB:2FC1" /db_xref="PDB:2FC2" /db_xref="PDB:4D3I" /db_xref="PDB:4D3J" /db_xref="PDB:4D3K" /db_xref="PDB:4D3M" /db_xref="PDB:4D3N" /db_xref="PDB:4D3O" /db_xref="PDB:4D3T" /db_xref="PDB:4D3U" /db_xref="PDB:4D3V" /db_xref="PDB:4D7H" /db_xref="PDB:4D7I" /db_xref="PDB:4D7J" /db_xref="PDB:4LWA" /db_xref="PDB:4LWB" /db_xref="PDB:4UG5" /db_xref="PDB:4UG6" /db_xref="PDB:4UG7" /db_xref="PDB:4UG8" /db_xref="PDB:4UG9" /db_xref="PDB:4UGA" /db_xref="PDB:4UGB" /db_xref="PDB:4UGC" /db_xref="PDB:4UGD" /db_xref="PDB:4UGE" /db_xref="PDB:4UGF" /db_xref="PDB:4UGG" /db_xref="PDB:4UGH" /db_xref="PDB:4UGI" /db_xref="PDB:4UGJ" /db_xref="PDB:4UGK" /db_xref="PDB:4UGL" /db_xref="PDB:4UGM" /db_xref="PDB:4UGN" /db_xref="PDB:4UGO" /db_xref="PDB:4UGP" /db_xref="PDB:4UGQ" /db_xref="PDB:4UGR" /db_xref="PDB:4UGS" /db_xref="PDB:4UGT" /db_xref="PDB:4UGU" /db_xref="PDB:4UGV" /db_xref="PDB:4UGW" /db_xref="PDB:4UGX" /db_xref="PDB:4UGY" /db_xref="PDB:4UQR" /db_xref="PDB:4UQS" /db_xref="PDB:5G65" /db_xref="PDB:5G66" /db_xref="PDB:5G67" /db_xref="PDB:5G68" /db_xref="PDB:5G69" /db_xref="PDB:5G6A" /db_xref="PDB:5G6B" /db_xref="PDB:5G6C" /db_xref="PDB:5G6D" /db_xref="PDB:5G6E" /db_xref="PDB:5G6F" /db_xref="PDB:5G6G" /db_xref="PDB:5G6H" /db_xref="PDB:5G6I" /db_xref="PDB:5G6J" /db_xref="PDB:5G6K" /db_xref="PDB:5G6L" /db_xref="PDB:5G6M" /db_xref="PDB:5G6N" /db_xref="PDB:5G6O" /db_xref="PDB:5G6P" /db_xref="PDB:5G6Q" /db_xref="SubtiList:BG12948" /db_xref="UniProtKB/Swiss-Prot:O34453" /translation="MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGS YVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATN NGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGW RGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPII SDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLW KDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPI SPAATHIFHRSYDNSIVKPNYFYQDKPYE*" /label="nosA CDS" gene 760878..761969 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /label="nosA gene" CDS complement(761960..762235) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /EC_number="3.6.1.7" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:20447399" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20447399; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphatase" /protein_id="NP_388645.1" /db_xref="EnsemblGenomes-Gn:BSU07640" /db_xref="EnsemblGenomes-Tr:CAB12593" /db_xref="GOA:O35031" /db_xref="InterPro:IPR001792" /db_xref="InterPro:IPR017968" /db_xref="InterPro:IPR020456" /db_xref="InterPro:IPR036046" /db_xref="PDB:2FHM" /db_xref="PDB:2HLT" /db_xref="PDB:2HLU" /db_xref="PDB:3BR8" /db_xref="SubtiList:BG12947" /db_xref="UniProtKB/Swiss-Prot:O35031" /translation="MLQYRIIVDGRVQGVGFRYFVQMEADKRKLAGWVKNRDDGRVEI LAEGPENALQSFVEAVKNGSPFSKVTDISVTESRSLEGHHRFSIVYS*" /label="acyP CDS" gene complement(761960..762235) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /label="acyP gene" S_feature 761970..762301 /Source="Nicolas_S_feature" /locus_tag="new_837745_838076" /HighExp="C90, BI, Paraq, LBGexp, Oxctl, M0t45, G150, M40t45, G135, H2O2" /AntisenseName="yflL" /AntisenseCor="0.38657275217332299" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S263" promotor_-10 complement(762249..762268) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(762263) /Source="Nicolas_upshifts" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(762283..762290) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 762302..762967 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11886751; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur carrier" /protein_id="NP_388646.1" /db_xref="EnsemblGenomes-Gn:BSU07650" /db_xref="EnsemblGenomes-Tr:CAB12594" /db_xref="GOA:O34542" /db_xref="InterPro:IPR005163" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="SubtiList:BG12946" /db_xref="UniProtKB/Swiss-Prot:O34542" /translation="MKQERYSVLSLNLGKPQTLEYDGKKIETGIMKRPAKSAVMLYRE NFEGDGQADLVNHGGPDKAVCVYPAEHYPFWEEFLSRPLSNAAFGENLTVAGLTEENV CIGDVFRLDEAVVQVSQPRQPCVKLAKKFGVKEMVLKVQQTGYTGFYFRVLEEGRVSP GANLELLSRGEKGISVQFANRINYHDAKNLTAIERILSEAALSESWRASFMKKKDRLL PVE*" /label="yflK CDS" gene 762302..762967 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /label="yflK gene" CDS complement(763008..763145) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388647.1" /db_xref="EnsemblGenomes-Gn:BSU07660" /db_xref="EnsemblGenomes-Tr:CAB12595" /db_xref="InterPro:IPR022580" /db_xref="SubtiList:BG12945" /db_xref="UniProtKB/Swiss-Prot:O34345" /translation="MHYGSKGWYVAELKKQGITHHEGRKLQSYKTYFLANLLESKKKQ S*" /label="yflJ CDS" gene complement(763008..763145) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /label="yflJ gene" downshifts complement(763022) /Source="Nicolas_upshifts" /id="D381" /incds=0 /nref=136 /ntot=260 /MaxReadThrough="0.0927600000000002" /MaxDrop="8.10929" /score="29.8336543" /energy="-14.8" /TU="NA" /idTUdmin="U583" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(763146..763276) /Source="Nicolas_S_feature" /locus_tag="new_838921_839051_c" /HighExp="S4, S7, S8, S6, S5, S3, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.967, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S264" promotor_-10 complement(763262..763280) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 763272..763277 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(763276) /Source="Nicolas_upshifts" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 763287..764351 /Source="Nicolas_S_feature" /locus_tag="new_839062_840126" /HighExp="S8, S6, S5, S7, S4, S3, BT, B36, C90, T5.0H" /AntisenseName="mapB" /AntisenseCor="-0.26446079057314398" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S265" upshifts 763288 /Source="Nicolas_upshifts" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 763293..763311 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(763296..763301) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(763302..763457) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388648.1" /db_xref="EnsemblGenomes-Gn:BSU07670" /db_xref="EnsemblGenomes-Tr:CAB12596" /db_xref="GOA:O34905" /db_xref="SubtiList:BG12944" /db_xref="UniProtKB/Swiss-Prot:O34905" /translation="MWFIIFGIIFFIEGIIMTVYGVKKKNGMLTYIGIVFAIMTFGVV MIKLTGH*" /label="yflI CDS" gene complement(763302..763457) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /label="yflI gene" S_feature complement(763458..763563) /Source="Nicolas_S_feature" /locus_tag="new_839233_839338_c" /HighExp="Etha, Salt, Diami, dia15, H2O2, Cold, G135, Paraq, LPhT, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S266" CDS complement(763564..763878) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1070366, 1266368; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388649.1" /db_xref="EnsemblGenomes-Gn:BSU07680" /db_xref="EnsemblGenomes-Tr:CAB12597" /db_xref="InterPro:IPR021637" /db_xref="PDB:3D0W" /db_xref="SubtiList:BG12943" /db_xref="UniProtKB/Swiss-Prot:O34306" /translation="MNRDQEKIQIENEMNAMHGTIKEDILKDFEEFKGYLKKQVNRGK KLGLDDGKLVKSAAILGDYLAKHEEPQNGEEMLLQELWSVADEDEKEHLAQLLVKLVD KQ*" /label="yflH CDS" gene complement(763564..763878) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /label="yflH gene" S_feature complement(763879..763959) /Source="Nicolas_S_feature" /locus_tag="new_839654_839734_c" /HighExp="dia5, dia15, Diami, LBGtran, LPhT, H2O2, Etha, Lbtran, M40t45, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S267" CDS complement(763960..764709) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase B" /protein_id="NP_388650.1" /db_xref="EnsemblGenomes-Gn:BSU07690" /db_xref="EnsemblGenomes-Tr:CAB12598" /db_xref="GOA:O34484" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG12942" /db_xref="UniProtKB/Swiss-Prot:O34484" /translation="MIVTNDQELEGLKKIGRIVALAREEMKRKAEPGMSTKDLDLIGK AVLDEHGAVSAPEKEYDFPGVTCISVNDEVAHGIPSTSKILKAGDLVNIDISAEFGGF YSDTGISFVLGEGEERLHKLCQCAENAFQKGLQQAKAGKRQNQIGRAVYHEARSQGFT VIKTLTGHGIGRSLHEAPNHIMNYYDPFDNALFKNGTVIALEPFISTKAETIVEAGDG WTFKTPDKSMVAQVEHTIVITKDEPIILTKL*" /label="mapB CDS" gene complement(763960..764709) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /label="mapB gene" promotor_-10 complement(764738..764757) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(764751) /Source="Nicolas_upshifts" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(764753..765889) /Source="Nicolas_S_feature" /locus_tag="new_840528_841664_c" /HighExp="S6, S8, S7, S5, BT, C30, Paraq, B36, G180, Pyr" /AntisenseName="nagP" /AntisenseCor="0.180776000778922" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S268" promotor_-35 complement(764769..764777) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 764820..764821 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 764841..764860 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 764844 /Source="Nicolas_upshifts" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="upshifts" CDS 764881..766239 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 8246840; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) N-acetylglucosamine-specific enzyme IICB component" /protein_id="NP_388651.1" /db_xref="EnsemblGenomes-Gn:BSU07700" /db_xref="EnsemblGenomes-Tr:CAB12599" /db_xref="GOA:O34521" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010974" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG12941" /db_xref="UniProtKB/Swiss-Prot:O34521" /translation="MLSFLQKLGKSFMLPIAVLPAVGIILALGREDVFNIPFVYQAGT AVFDHLPLIFAIGIAIGISKDSNGAAGLSGAISYLMLDAATKTIDKTNNMAVFGGIIA GLIAGYTYNRFKDTKLPEYLGFFSGRRLVPILTAIITIILAGIFGVVWPPIQSCINSF GEWMLGLGGIGAGIFGLFNRLLIPLGLHHVLNNIFWFQFGEYNGVTGDLARFFAKDPT AGTYMTGFFPIMMFGLPAACLAMVVTAKPSKRKATAGMMIGFALTAFITGITEPIEFA FMFLSPLLYAVHAVLTGLSLFIVNWLGIRSGFSFSAGAIDYVLSYGIAEKPLLLLLVG ICYAAVYFIVFYVLIKALNLKTPGREDDDVDEVLDENTVQDVNENIMLKGLGGKENLQ TIDHCATRLRLTVKDTALVDEALLKKAGAKGVVKSGGQSVQVIIGPNVEFAAEELRAA VK*" /label="nagP CDS" gene 764881..766239 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /label="nagP gene" promotor_-10 complement(765875..765894) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(765889) /Source="Nicolas_upshifts" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(765908..765917) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 766125 /Source="Nicolas_upshifts" /id="D382" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="3.67421" /MaxDrop="3.12268" /score="44.7832762" /energy="-16.9" /TU="U586" /idTUdmin="U586" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 766235 /Source="Nicolas_upshifts" /id="D383" /incds=0 /nref=2 /ntot=87 /MaxReadThrough="2.54331" /MaxDrop="3.17508" /score="44.7832762" /energy="-16.9" /TU="NA" /idTUdmin="U586" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(766272..768221) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10658653, 21255105" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658653, 21255105; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_388652.1" /db_xref="EnsemblGenomes-Gn:BSU07710" /db_xref="EnsemblGenomes-Tr:CAB12600" /db_xref="GOA:O34952" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="PDB:2W8D" /db_xref="SubtiList:BG12940" /db_xref="UniProtKB/Swiss-Prot:O34952" /translation="MKTFIKERGLAFFLIAVVLLWIKTYVGYVLNFNLGIDNTIQKIL LFVNPLSSSLFFLGFGLLFKKKLQQTAIIVIHFLMSFLLYANIVYYRFFNDFITIPVI MQAKTNGGQLGDSAFSLMRPTDAFYFIDTIILIILAIKVNKPAETSSKKSFRIIFASS ILVFLINLAVAESDRPELLTRSFDRNYLVKYLGTYNFTIYDAVQNIKSNSQRALADSS DVTEVENYMKANYDVPNNVYFGKAEGKNVIYVSLESLQSFIIDYKIDGKEVTPFLNKL AHDNETFYFDNFFHQTGQGKTSDAEFMMENSLYPLAQGSVFVNKAQNTLQSVPAILKS KNYTSATFHGNTQTFWNRNEMYKAEGIDKFFDSAYYDMNEENTKNYGMKDKPFFKESM PLLESLPQPFYTKFITLSNHFPFGMDEGDTDFPAGDFGDSVVDNYFQSAHYLDQSIEQ FFNDLKKDGLYDKSIIVMYGDHYGISENHNKAMAKVLGKDEITDYDNAQLQRVPLFIH AAGVKGEKVHKYAGDVDVAPTILHLLGVDTKDYLMSGSDILSKEHREVIPFRNGDFIS PKYTKISGKYYDTKTGKELDESEVDKSEDSLVKKELEMSDKIINGDLLRFYEPKGFKK VNPSDYDYTKHDEDSSETSKDNEDK*" /label="ltaSB CDS" gene complement(766272..768221) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /label="ltaSB gene" downshifts complement(766289) /Source="Nicolas_upshifts" /id="D384" /incds=0 /nref=219 /ntot=250 /MaxReadThrough="1.71031" /MaxDrop="6.08461" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U589" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 767331..767337 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 767353..767371 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 767357..768321 /Source="Nicolas_S_feature" /locus_tag="new_843132_844096" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, S8, B60, BC, S7" /AntisenseName="yflE" /AntisenseCor="-0.385555454026206" /AntisenseRegPval="-10.199999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S269" upshifts 767357 /Source="Nicolas_upshifts" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(768222..768296) /Source="Nicolas_S_feature" /locus_tag="new_843997_844071_c" /HighExp="Paraq, H2O2, LBGexp, G150, G135, G180, Lbexp, C30, LPhT, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S270" promotor_-10 complement(768273..768292) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(768296) /Source="Nicolas_upshifts" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(768298..768820) /Source="Nicolas_S_feature" /locus_tag="new_844073_844595_c" /HighExp="S3, LoTm, S7, S4, S5, S8, S6, M9-stat, C30, Pyr" /AntisenseName="yflD" /AntisenseCor="0.24383322556613099" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S271" promotor_-35 complement(768308..768312) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 768322..768459 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388653.1" /db_xref="EnsemblGenomes-Gn:BSU07720" /db_xref="EnsemblGenomes-Tr:CAB12601" /db_xref="SubtiList:BG12939" /db_xref="UniProtKB/Swiss-Prot:O34489" /translation="MREKVAKNAVESTFRFDITKCKTRYLSRNKGIKWYIENCMIKYK V*" /label="yflD CDS" gene 768322..768459 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /label="yflD gene" upshifts 768437 /Source="Nicolas_upshifts" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="upshifts" misc_feature 768438..768457 /Source="Nicolas_upshift_promotors" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 768478..768870 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388655.2" /db_xref="EnsemblGenomes-Gn:BSU07735" /db_xref="EnsemblGenomes-Tr:CAB12603" /db_xref="InterPro:IPR018961" /db_xref="SubtiList:BG12937" /db_xref="UniProtKB/Swiss-Prot:O34887" /translation="MDFSHIVSEDKIKRAIKDGDFQNLPGMGKPLPKDDAAHLPESLR MGYRILKNAGMAEDEGALKKELMTIDHLIEKCYDEKEREQLIRKKSEKQLLLDKLVDK KGMFSKPASAFYKNKVYDRLGRNRPSSS*" /label="yflB CDS" gene 768478..768870 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /label="yflB gene" promotor_-10 complement(768818..768836) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(768833) /Source="Nicolas_upshifts" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(768852..768857) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 768939..768945 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 768960..768978 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 768960 /Source="Nicolas_upshifts" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="upshifts" CDS 768995..770410 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid transporter" /protein_id="NP_388656.1" /db_xref="EnsemblGenomes-Gn:BSU07750" /db_xref="EnsemblGenomes-Tr:CAB12604" /db_xref="GOA:O34708" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12936" /db_xref="UniProtKB/Swiss-Prot:O34708" /translation="MERLLVWIEHISDWLWGPPLIILLTGTGLYFTILLKGFQFRYPL YIFKQTIGSVGKKPKGEGTVTPLQALTSALSSTIGAANIVGVPAAIMFGGPGAVFWMW LIALFAMAIKFSESVLAVHYREKNEQGEYVGGPMYYITKGLRMKWLGVFFSVALIVEL IPSIMVQGNSVSVSLAETFSFNKIYAGIGIAFLIGLVVIGGVKRIGKVTEFVVPLMAG AYAGAGLLIVLMNLSSVPAFFSLVFSNAFTSSSAVGGFAGAALAETVRWGFARGLYSN EAGMGTAPIAHAAAMTDHPVRQGFWSVIGIVIDTLIICTTTAFIVLASGVWTGKNASN DPAALTTAAFQHYFGSGGGYFVSVSLVFFVVSTIMVVIFYGVKQAEFLFGRLAGHVIK FVYLAAIIIGAAGGAKAIWGVLDLALVFIVVPNVIALLLLSRKVKALYTEFFTSEQYY LKDIRKTKQKPVYPTKEAKNS*" /label="yflA CDS" gene 768995..770410 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /label="yflA gene" downshifts complement(768996) /Source="Nicolas_upshifts" /id="D385" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="0.76492" /MaxDrop="4.20973" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U593" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(769022..769122) /Source="Nicolas_upshift_promotors" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(769062) /Source="Nicolas_upshifts" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(770407..771483) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406, 23625846; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane transporter" /protein_id="NP_388657.1" /db_xref="EnsemblGenomes-Gn:BSU07760" /db_xref="EnsemblGenomes-Tr:CAB12605" /db_xref="GOA:O34573" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG12935" /db_xref="UniProtKB/Swiss-Prot:O34573" /translation="MDKTSAYQGLFFGALYTLAVGLKHAPILMIESAKQNAWHSYILG VVIVIPALWLMHRLMKKHQDKNIYELLSDSSPIAGRIIILLFSLYFLLINAHDIRFFI NLINILFLPRTPMAVLGGVIIFVAICIAREGKETLTRMAQIFLFPFGILVLFLPFTLA TQIELQNLTPVFEGLIPYLQSGYYAFGTMGELIILPLLFSNRSVPLKYTIFAILLGAL LLAVMLFSSISVFGPNLTSTFFDPAYMVIRQIRITDFLDRSDLIIAAFWIPVIMVKIA GSLYIVVYGLSFLHSKIDPKAMYTPTGMFSVVCGFWFFLNTNQLIDFNRIKPIINVVI SLLLPLLIYLIIKSKALFGAKAKH*" /label="yfkT CDS" gene complement(770407..771483) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /label="yfkT gene" S_feature 770411..773777 /Source="Nicolas_S_feature" /locus_tag="new_846186_849552" /HighExp="Salt, Sw, Etha, LoTm, B36, Heat, LPhT, BC, T0.30H, H2O2" /AntisenseName="yfkR" /AntisenseCor="-1.3937740774571999E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.952" /label="S272" CDS complement(771507..771707) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative spore germination D protein" /protein_id="NP_388658.1" /db_xref="EnsemblGenomes-Gn:BSU07770" /db_xref="EnsemblGenomes-Tr:CAB12606" /db_xref="GOA:O35036" /db_xref="SubtiList:BG12934" /db_xref="UniProtKB/Swiss-Prot:O35036" /translation="MISYIVQTLIVCIAIYAYEWKNFRSANNLTKWAFSLLIAGSAFL WIYMRVNPLLPRLGHLFKYIPF*" /label="yfkS CDS" gene complement(771507..771707) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /label="yfkS gene" CDS complement(771723..772877) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388659.1" /db_xref="EnsemblGenomes-Gn:BSU07780" /db_xref="EnsemblGenomes-Tr:CAB12607" /db_xref="GOA:O35028" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG12933" /db_xref="UniProtKB/Swiss-Prot:O35028" /translation="MKKTIYKCVLPLLICILLTGCWDRTEINDIAFVVSSAIDKKKDQ YRVAMQIPLVGQLGGQTGGGGGTAGSKTWYVDSASGTTIREANNKLQTSLSRTINTSH RRTVIIGEDMARDGVAPVFDILTRNPQNRLTALILVSRGEARDILNTDVQLEQFPAEM IRELAIIATSRPVFLSRFMSDLVEIGSDPYAPVISASKTKPGGKGKSNLKIDGLAIFK KDRLMDIFKDEHMTAALMLLNQARQPEFIVDLPNQMGQASIQLQKSNASFHAAEKNGK LSMTIEIRAKGIIMENQSTYETRENDQYYIIQKALNRTIKKDVISTVHRLQKLKADPA GFQDRTIRSTATTKNLLKKEWEEVYKDMEVHVVPIVTIEQGGVLYKTISH*" /label="yfkR CDS" gene complement(771723..772877) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /label="yfkR gene" CDS complement(772858..774399) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388660.1" /db_xref="EnsemblGenomes-Gn:BSU07790" /db_xref="EnsemblGenomes-Tr:CAB12608" /db_xref="GOA:O34486" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG12932" /db_xref="UniProtKB/Swiss-Prot:O34486" /translation="MNKRDKALQLIKELEDNQDRPISPNLKENLENLTLLTEGCSDIV FRQFDFGNGLCGFIVYIEGIVKSEHIQDHALRPFLMHLTDQIDEHEEALQNTLSISSV ALETSMSKVAASIIEGNAVLFADGHSKGLILNIKGGQRRSIEEPITESTIRGSREGFT ESLRVNTALVRFRVKTFQLKMISFKIGTKTKTDVVLAYIDGLADPKVIDKAKKRIKKI KIDAVLESGYIEEFIEDDTYSPFPQLQYTERPDTVAAQLLEGRFAIFTDNTPFVLTGP ITFWQLMQASEDYYERYLMSNLIRWLRYMFLFVALYLPAIYVAVITYHQDLMPTNLMF SVASAREPIPFPAIIEALIMEISFEALREAGVRLPKTIGQTVSILGALVIGTAAVEAG IVSAPMVIIVSLTGIASFTIPRFNLAISIRMLRFPLMFLASIFGIFGIMLGTIILVLH LCKLQSFGIPYLSGISPFKRDEVKDIFVRAPWWTMTRRPGTYSRGNGQKGAKREDPKD EENNI*" /label="yfkQ CDS" gene complement(772858..774399) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /label="yfkQ gene" promotor_-10 complement(774449..774460) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(774452) /Source="Nicolas_upshifts" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(774474..774480) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 774509..774516 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 774531..774550 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 774538 /Source="Nicolas_upshifts" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(774584) /Source="Nicolas_upshifts" /id="D386" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="1.35091" /MaxDrop="3.57201" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U596" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 774592..776004 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /EC_number="2.7.1.201" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 8755887, 8917076, 8969503, 18977770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 8755887, 8917076, 8969503, 18977770; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) trehalose-specific enzyme IIBC component" /protein_id="NP_388661.1" /db_xref="EnsemblGenomes-Gn:BSU07800" /db_xref="EnsemblGenomes-Tr:CAB12609" /db_xref="GOA:P39794" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011296" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11009" /db_xref="UniProtKB/Swiss-Prot:P39794" /translation="MGELNKSARQIVEAVGGAENIAAATHCVTRLRFALIDESKVDQE MLDQIDVVKGSFSTNGQFQVVIGQGTVNKVYAELVKETGIGESTKDEVKKASEKNMNP LQRAVKTLADIFIPILPAIVTAGLLMGINNILTAEGIFFSTKSIVQVYPQWADLANMI NLIAGTAFTFLPALIGWSAVKRFGGNPLLGIVLGVMLVHPDLLNAWGYGAAEQSGEIP VWNLFGLEVQKVGYQGQVLPILLASYMLAKIEVFLTKRTPEGIQLLVVAPITLLLTGF ASFIIIGPITFAIGNVLTSGLISVFGSFAALGGLLYGGFYSALVITGMHHTFLAVDLQ LIGSKLGGTFLWPMLALSNIAQGSAALAMMFIVKDEKQKGLSLTSGISAYLGITEPAI FGVNLRYRFPFIIAMVSSGLAGMYISSQGVLASSVGVGGVPGIFSIMSQYWGAFAIGM AIVLIVPFAGTYAYARFKHK*" /label="treP CDS" gene 774592..776004 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /label="treP gene" promotor_no_box complement(774610..774710) /Source="Nicolas_upshift_promotors" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(774650) /Source="Nicolas_upshifts" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 776075..777760 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /EC_number="3.2.1.93" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651129, 7751281, 8755887, 8917076, 9701821, 26894535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651129, 7751281, 8755887, 8917076, 9701821, 26894535; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="trehalose-6-phosphate hydrolase" /protein_id="NP_388662.1" /db_xref="EnsemblGenomes-Gn:BSU07810" /db_xref="EnsemblGenomes-Tr:CAB12610" /db_xref="GOA:P39795" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR012769" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG11010" /db_xref="UniProtKB/Swiss-Prot:P39795" /translation="MKTEQTPWWKKAVVYQIYPKSFNDTTGNGVGDLNGIIEKLDYLK TLQVDVLWLTPIYDSPQHDNGYDIRDYYSIYPEYGTMEDFERLVSEAHKRDLKVVMDL VVNHTSTEHKWFREAISSIDSPYRDFYIWKKPQENGSVPTNWESKFGGSAWELDEASG QYYLHLFDVTQADLNWENEEVRKHVYDMMHFWFEKGIDGFRLDVINLISKDQRFPNAE EGDGRSFYTDGPRVHEFLHEMNEKVFSHYDSMTVGEMSSTTVDHCIRYTNPDNKELDM TFSFHHLKVDYPNGEKWALAPFDFLKLKEILSDWQTGMHAGGGWNALFWCNHDQPRVV SRYGDDGAYRVKSAKMLATAIHMMQGTPYIYQGEELGMTNPKFTDISSYRDVESLNMY HAFKEKGMADQDITAILQAKSRDNSRTPVQWDATENGGFTTGTPWIPVAGNYREINAE AALRDQNSVFYHYQKLIQIRKMYDIVTEGTYEIIAKDDPNIFAYLRHGSNEKLLVINN FYGTEAAFTLPDSLAPDEWKAEVLLTNDEAREGLQNMTLRPYESIVYRLTKPC*" /label="treA CDS" gene 776075..777760 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /label="treA gene" promotor_-10 complement(776381..776396) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(776388) /Source="Nicolas_upshifts" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(776409..776418) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 777733..777737 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 777753..777772 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 777756 /Source="Nicolas_upshifts" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 777781..778497 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755887, 9829827, 17705272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755887, 9829827, 17705272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TreR-trehalose)" /protein_id="NP_388663.1" /db_xref="EnsemblGenomes-Gn:BSU07820" /db_xref="EnsemblGenomes-Tr:CAB12611" /db_xref="GOA:P39796" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR012770" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OGG" /db_xref="SubtiList:BG11011" /db_xref="UniProtKB/Swiss-Prot:P39796" /translation="MKVNKFITIYKDIAQQIEGGRWKAEEILPSEHELTAQYGTSRET VRKALHMLAQNGYIQKIRGKGSVVLNREKMQFPVSGLVSFKELAQTLGKETKTTVHKF GLEPPSELIQKQLRANLDDDIWEVIRSRKIDGEHVILDKDYFFRKHVPHLTKEICENS IYEYIEGELGLSISYAQKEIVAEPCTDEDRELLDLRGYDHMVVVRNYVFLEDTSLFQY TESRHRLDKFRFVDFARRGK*" /label="treR CDS" gene 777781..778497 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /label="treR gene" downshifts 778490 /Source="Nicolas_upshifts" /id="D387" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="6.58905" /MaxDrop="4.05981" /score="24.6748216" /energy="-11.1" /TU="U595,U598" /idTUdmin="U595" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" promotor_-35 778572..778575 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 778591..778610 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 778600 /Source="Nicolas_upshifts" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 778637..779302 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /EC_number="1.5.1.39" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15252706, 20727918, 20862523, 22238377, 26415543" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 20727918, 20862523, 22238377, 26415543; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H-flavin oxidoreductase (nitroreductase)" /protein_id="NP_388664.1" /db_xref="EnsemblGenomes-Gn:BSU07830" /db_xref="EnsemblGenomes-Tr:CAB12612" /db_xref="GOA:O34475" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="InterPro:IPR033878" /db_xref="SubtiList:BG12931" /db_xref="UniProtKB/Swiss-Prot:O34475" /translation="MADLKTQILDAYNFRHATKEFDPNKKVSDSDFEFILETGRLSPS SLGLEPWKFVVVQNPEFREKLREYTWGAQKQLPTASHFVLILARTAKDIKYNADYIKR HLKEVKQMPQDVYEGYLSKTEEFQKNDLHLLESDRTLFDWASKQTYIALGNMMTAAAQ IGVDSCPIEGFQYDHIHRILEEEGLLENGSFDISVMVAFGYRVRDPRPKTRSAVEDVV KWV*" /label="hypO CDS" gene 778637..779302 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /label="hypO gene" downshifts 779283 /Source="Nicolas_upshifts" /id="D388" /incds=0 /nref=180 /ntot=269 /MaxReadThrough="0.70079" /MaxDrop="6.77615" /score="34.5750428" /energy="-16.9" /TU="NA" /idTUdmin="U595" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(779339..783727) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /EC_number="3.1.4.16" /EC_number="3.1.3.5" /EC_number="3.1.3.6" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14688230, 16291680, 21800427, 21906378, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported 2',3'-cyclic-nucleotide 2'-phosphodiesterase, 2' (or 3') nucleotidase and 5' nucleotidase" /protein_id="NP_388665.1" /db_xref="EnsemblGenomes-Gn:BSU07840" /db_xref="EnsemblGenomes-Tr:CAB12613" /db_xref="GOA:O34313" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="PDB:3GVE" /db_xref="SubtiList:BG12930" /db_xref="UniProtKB/Swiss-Prot:O34313" /translation="MRIQKRRTHVENILRILLPPIMILSLILPTPPIHAEESAAPQVH LSILATTDIHANMMDYDYYSDKETADFGLARTAQLIQKHREQNPNTLLVDNGDLIQGN PLGEYAVKYQKDDIISGTKTHPIISVMNALKYDAGTLGNHEFNYGLDFLDGTIKGADF PIVNANVKTTSGENRYTPYVINEKTLIDENGNEQKVKVGYIGFVPPQIMTWDKKNLEG QVQVQDIVESANETIPKMKAEGADVIIALAHTGIEKQAQSSGAENAVFDLATKTKGID AIISGHQHGLFPSAEYAGVAQFNVEKGTINGIPVVMPSSWGKYLGVIDLKLEKADGSW KVADSKGSIESIAGNVTSRNETVTNTIQQTHQNTLEYVRKPVGKTEADINSFFAQVKD DPSIQIVTDAQKWYAEKEMKDTEYKNLPILSAGAPFKAGGRNGANYYTNIPAGDLAIK NVGDLYLYDNTVQIVKLTGSEVKDWLEMSAGQFNQIDPAKGGDQALLNENFRSYNFDV IDGVTYQVDVTKPAKYNENGKVINADSSRIINLSYEGKPISPSQEFLVVTNNYRASGG GGFPHLTSDKIVHGSAVENRQVLMDYIIEQKTVNPKADNNWSIAPVSGTNLTFESSLL AKPFADKADDVAYVGKSANEGYGVYKLQFDDDSNPDPPKDGLWDLTVMHTNDTHAHLD DAARRMTKINEVRSETNHNILLDAGDVFSGDLYFTKWNGLADLKMMNMMGYDAMTFGN HEFDKGPTVLSDFLSGNSATVDPANRYHFEAPEFPIVSANVDVSNEPKLKSFVKKPQT FTAGEKKEAGIHPYILLDVDGEKVAVFGLTTEDTATTSSPGKSIVFNDAFETAQNTVK AIQEEEKVNKIIALTHIGHNRDLELAKKVKGIDLIIGGHTHTLVDKMEVVNNEEPTIV AQAKEYGQFLGRVDVAFDEKGVVQTDKSNLSVLPIDEHTEENPEAKQELDQFKNELED VKNEKVGYTDVALDGQREHVRTKETNLGNFIADGMLAKAKEAAGARIAITNGGGIRAG IDKGDITLGEVLNVMPFGNTLYVADLTGKQIKEALEQGLSNVENGGGAFPQVAGIEYT FTLNNKPGHRVLEVKIESPNGDKVAINTDDTYRVATNNFVGAGGDGYSVFTEASHGED LGYVDYEIFTEQLKKLGNKVSPKVEGRIKEVFLPTKQKDGSWTLDEDKFAIYAKNANT PFVYYGIHEGSQEKPINLKVKKDQVKLLKERESDPSLTMFNYWYSMKMPMANLKTADT AIGIKSTGELDVSLSDVYDFTVKQKGKEIKSFKEPVQLSLRMFDIEEAHNPAIYHVDR KKKAFTKTGHGSVDDDMVTGYTNHFSEYTILNSGSNNKPPAFPSDQPTGGDDGNHGGG SDKPGGKQPTDGNGGNDTPPGTQPTNGSGGNGSGGSGTDGPAGGLLPDTATSMYSILL AGFLISALGTAMYLHQRRKQNRANQA*" /label="yfkN CDS" gene complement(779339..783727) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /label="yfkN gene" downshifts complement(779358) /Source="Nicolas_upshifts" /id="D389" /incds=0 /nref=155 /ntot=229 /MaxReadThrough="1.00159" /MaxDrop="7.08591" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(783760..783779) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(783777) /Source="Nicolas_upshifts" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(783794..783797) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 783904..783910 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 783924..783942 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 783927 /Source="Nicolas_upshifts" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 783970..784488 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="general stress protein 18; deglycase" /protein_id="NP_388666.1" /db_xref="EnsemblGenomes-Gn:BSU07850" /db_xref="EnsemblGenomes-Tr:CAB12614" /db_xref="GOA:P80876" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12929" /db_xref="UniProtKB/Swiss-Prot:P80876" /translation="MGKKIAVVLTYYFEDSEYTEPAKAFKEAGHELTVIEKEKGKTVK GKQGTAEVTVDASIDDVNSSDFDALLIPGGFSPDQLRADDRFVQFTKAFMTDKKPVFA ICHGPQLLINAKALDGRKATGYTSIRVDMENAGADVVDKEVVVCQDQLVTSRTPDDIP AFNRESLALLEK*" /label="sufLB CDS" gene 783970..784488 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /label="sufLB gene" downshifts 784474 /Source="Nicolas_upshifts" /id="D390" /incds=0 /nref=35 /ntot=153 /MaxReadThrough="8.02255" /MaxDrop="6.97573" /score="42.2080398" /energy="-12.9" /TU="U601" /idTUdmin="U601" /TUdmin="-3542" /isTUend="FALSE" /label="downshifts" downshifts complement(784518) /Source="Nicolas_upshifts" /id="D391" /incds=0 /nref=22 /ntot=199 /MaxReadThrough="1.59285" /MaxDrop="3.61098" /score="31.1923457" /energy="-11.1" /TU="NA" /idTUdmin="U602" /TUdmin=10 /isTUend="TRUE" /label="downshifts" S_feature 784519..786169 /Source="Nicolas_S_feature" /locus_tag="new_860294_861944" /HighExp="Etha, S6, S8, S5, S7, Gly, Salt, LoTm, S4, Diami" /AntisenseName="yfkL" /AntisenseCor="-0.52109661167911703" /AntisenseRegPval="-19.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S273" CDS complement(784528..785718) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16828913, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter" /protein_id="NP_388667.1" /db_xref="EnsemblGenomes-Gn:BSU07860" /db_xref="EnsemblGenomes-Tr:CAB12615" /db_xref="GOA:O34597" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12928" /db_xref="UniProtKB/Swiss-Prot:O34597" /translation="MQTTSIKTASGMYINYFFLGMVNIILASNMSSLTKQWNTDPTGI SYVIAAIGFGKLLTYGISGVLSDKIGRKPLVVASAGIMAVFLVGIPLSPSYELAFVFA LLAGVANSAMDAGTYPALTELFPSASGSANVLVKAFMSVGAALLPLLITFLADHSMFY GFAFYLPAAVYLLNIIYLSTLSFPKKHKKPTNSGQQESPVFLSEPVFQKEGTALIIIG FTSTALFTVSQIWLPSYAQKAAGLAESASVQLLSYYSIGSLASVLLLAVLLNRWVKPV FITLLYPIITLCTLAVMLTVHIPVVLDITAFFLGFSTAGVFQITITLMTELFWKRKGT VTGIVATASSLASILLPIATGLIAKAGGIAHIFIFDFGIAVIGTAAAAFLYYRYKKLT GAQA*" /label="yfkL CDS" gene complement(784528..785718) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /label="yfkL gene" S_feature complement(785719..785810) /Source="Nicolas_S_feature" /locus_tag="new_861494_861585_c" /HighExp="C90, MG 10, BMM, MG-0.2, MG t5, MG 5, MG-0.1, UNK1, HPh, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S274" CDS complement(785811..786026) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388668.1" /db_xref="EnsemblGenomes-Gn:BSU07870" /db_xref="EnsemblGenomes-Tr:CAB12616" /db_xref="InterPro:IPR009507" /db_xref="SubtiList:BG12927" /db_xref="UniProtKB/Swiss-Prot:O35019" /translation="MSSPNTETLTQMIEEISQKLNMLNVGVIKAEDFSDEKIEDLTYL HRMVMKKESFSPSEMQAIAQELASLRK*" /label="yfkK CDS" gene complement(785811..786026) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /label="yfkK gene" downshifts complement(785870) /Source="Nicolas_upshifts" /id="D392" /incds=0 /nref=1 /ntot=131 /MaxReadThrough="3.65318" /MaxDrop="2.45155" /score="16.183887" /energy="-11.6" /TU="U602" /idTUdmin="U602" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(786058..786077) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(786072) /Source="Nicolas_upshifts" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(786092..786093) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 786139..786146 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 786161..786180 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 786171 /Source="Nicolas_upshifts" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 786229..786699 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /EC_number="3.1.3.48" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-tyrosine-phosphatase" /protein_id="NP_388669.1" /db_xref="EnsemblGenomes-Gn:BSU07880" /db_xref="EnsemblGenomes-Tr:CAB12617" /db_xref="GOA:O35016" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:4ETM" /db_xref="SubtiList:BG12926" /db_xref="UniProtKB/Swiss-Prot:O35016" /translation="MISVLFVCLGNICRSPMAEAIFRDLAAKKGLEGKIKADSAGIGG WHIGNPPHEGTQEILRREGISFDGMLARQVSEQDLDDFDYIIAMDAENIGSLRSMAGF KNTSHIKRLLDYVEDSDLADVPDPYYTGNFEEVCQLIKTGCEQLLASIQKEKQL*" /label="yfkJ CDS" gene 786229..786699 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /label="yfkJ gene" CDS 786717..787037 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388670.1" /db_xref="EnsemblGenomes-Gn:BSU07890" /db_xref="EnsemblGenomes-Tr:CAB12618" /db_xref="SubtiList:BG12925" /db_xref="UniProtKB/Swiss-Prot:O34418" /translation="MNNERLMLKGIFLGAAAGAALSLLHKPTRQACGMRWLTCKHKLS LYKSNPELLKNTVITKVDEAKKLARTLSKEVDFVNQQVKELKKTTPQVMELVQETKEH FSKK*" /label="yfkI CDS" gene 786717..787037 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /label="yfkI gene" CDS 787061..787888 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222749, 12794188, 15849754, 16850406, 15764599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease BN" /protein_id="NP_388671.1" /db_xref="EnsemblGenomes-Gn:BSU07900" /db_xref="EnsemblGenomes-Tr:CAB12619" /db_xref="GOA:O34437" /db_xref="InterPro:IPR017039" /db_xref="SubtiList:BG12924" /db_xref="UniProtKB/Swiss-Prot:O34437" /translation="MSFLKELFSRYTLHEGQSKSAELAYFFLLSLFPFLIFMLTLTAY LPLSTDDVLGVIEQYAPASAMSLVESITHQTLNNRNGGLLSFGIIAALWSASNGMNAI VRSLNHAYDVEENRSFIIVRLTSIFLTIAMVFTILVALLLPVFGREIGRLASDFVGAS DLFLSVWAAIRWGVSPLVLLIVFSALYVIAPNKKLSLRFVMPGAVFATIGWIIVSTLF SFYVSTFANYSATYGSIGGIIVLMIWFYLSGILIILGGEINALLHKRKKLPDENPYH* " /label="rbn CDS" gene 787061..787888 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /label="rbn gene" promotor_-35 787867..787873 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 787888..787899 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 787906..788062 /Source="Nicolas_S_feature" /locus_tag="new_863681_863837" /HighExp="S8, Etha, S6, Salt, S7, S5, ferm, nit, BT, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99976299999999996" /TUshortSig="SigGF, SigA, SigB" /TUshortPSig="0.974, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S275" upshifts 787906 /Source="Nicolas_upshifts" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(787938) /Source="Nicolas_upshifts" /id="D393" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.22239" /MaxDrop="3.61507" /score="-5.45682213" /energy="-3" /TU="NA" /idTUdmin="U606" /TUdmin=440 /isTUend="FALSE" /label="downshifts" downshifts 788037 /Source="Nicolas_upshifts" /id="D394" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="1.4253" /MaxDrop="6.85849" /score="25.8200126" /energy="-17.9" /TU="NA" /idTUdmin="U603" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(788087..789262) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388672.1" /db_xref="EnsemblGenomes-Gn:BSU07910" /db_xref="EnsemblGenomes-Tr:CAB12620" /db_xref="GOA:O34929" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12923" /db_xref="UniProtKB/Swiss-Prot:O34929" /translation="MSRFHFFILVLLVSISGFSQGMLLPVISIIFETNGESAAINGLH ATGLYIGVLLASPFMEAPLRKLGFKPLIVMGGSIVILSLFGFIWLQSVWVWFLLRLFI GIGDHMLHFSTQTWVTSMSSKQNRGRNLSIYGLSFGLGFAAGPFMVPLVKLSPSLPFI VSGCISLFAWLFVFFLQNAYPETSPHETKSDNSFRRFYQAMLFGWVAFMPTFGYGFLE TALNGSFPVYALRLGISVDAVAIILPAFAIGSIIFQFPLGILSDKYGRRNVLLVILLT GALCFFIAGVFPSPYVIGGCFFIAGMAVGSTFTLGISYMTDLLPPHLLPAGNLLCGIT FSLGSILGPVAGGWYMQTFESANLFYFITLTLSSVWLALVLGKPKSWSPAETYSSSS* " /label="yfkF CDS" gene complement(788087..789262) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /label="yfkF gene" downshifts complement(788092) /Source="Nicolas_upshifts" /id="D395" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="0.37084" /MaxDrop="3.28031" /score="3.2266059" /energy="-14.1" /TU="NA" /idTUdmin="U606" /TUdmin=286 /isTUend="FALSE" /label="downshifts" promotor_-35 788699..788705 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 788721..788739 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 788725..789378 /Source="Nicolas_S_feature" /locus_tag="new_864500_865153" /HighExp="Etha, M9-stat, Salt, Sw, Gly, B60, Heat, LPhT, HiTm, T0.30H" /AntisenseName="yfkF" /AntisenseCor="-0.18505347560608301" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S276" upshifts 788725 /Source="Nicolas_upshifts" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(789287..789306) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(789302) /Source="Nicolas_upshifts" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(789320..789327) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 789368..789373 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 789380 /Source="Nicolas_upshifts" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 789388..789406 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 789430..790485 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19543710, 23798403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19543710, 23798403; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+/Ca2+ antiporter" /protein_id="NP_388673.1" /db_xref="EnsemblGenomes-Gn:BSU07920" /db_xref="EnsemblGenomes-Tr:CAB12621" /db_xref="GOA:O34840" /db_xref="InterPro:IPR004713" /db_xref="InterPro:IPR004798" /db_xref="InterPro:IPR004837" /db_xref="PDB:4KJR" /db_xref="PDB:4KJS" /db_xref="SubtiList:BG12922" /db_xref="UniProtKB/Swiss-Prot:O34840" /translation="MNRIFFILVAAGVPLSVIGSLMHWPSAVLFAVYCVTIIALASYM GRATESLSIIAGPRIGGLLNATFGNAVELIISLFALKEGLTGIVLASLTGSVLGNLLL VAGLSFFVGGLKYKRQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSI GISIIMILLYVAALYFKLVTHRGVYQPNNAAQTEEEEEPEWSGKVATIVLFAATIVVA YISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAV GSTLQIAMFVAPVLVICSIFFPTSMPLVFTLPELVAMVSAVLLMIAISNDGDSNWFEG ATLLAAYVIMAIGFFLL*" /label="chaA CDS" gene 789430..790485 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /label="chaA gene" promotor_-35 790499..790505 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 790520..790531 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 790524 /Source="Nicolas_upshifts" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="upshifts" CDS 790556..791350 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19543710" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388674.1" /db_xref="EnsemblGenomes-Gn:BSU07930" /db_xref="EnsemblGenomes-Tr:CAB12622" /db_xref="InterPro:IPR025548" /db_xref="SubtiList:BG12921" /db_xref="UniProtKB/Swiss-Prot:O34579" /translation="MMKKLFHSTLIVLLFFSFFGVQPIHAKKQFKVPNSVASISKENT YPNASQDQPMLQPSKLAKELLDHSEVKIENPHLIKMLNESNISGTPLAVGYRATIFLG KWALGYESNETVANWEYKKINTNRADNRGGKETAEMHYAQEQQYRVKGGLTAKVPNAE DVKSMMMQKAMKKTNLPLAFETVIGAGTKRDQIYKVAPKKIGYLHAYAPAVNEKGKVT YGEVYLVLKGNKRKLVVKNVTSQGIGAWIPVQDHVTFGFQLSSLPR*" /label="yfkD CDS" gene 790556..791350 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /label="yfkD gene" downshifts 791338 /Source="Nicolas_upshifts" /id="D396" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="0.82657" /MaxDrop="5.7252" /score="28.7014976" /energy="-9.5" /TU="NA" /idTUdmin="U605" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(791389..792231) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17665170, 18310427, 19252899; Product type t: transporter" /codon_start=1 /transl_table=11 /product="mechanosensitive ion channel" /protein_id="NP_388675.1" /db_xref="EnsemblGenomes-Gn:BSU07940" /db_xref="EnsemblGenomes-Tr:CAB12623" /db_xref="GOA:O35043" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="SubtiList:BG12920" /db_xref="UniProtKB/Swiss-Prot:O35043" /translation="MRMKETLTEIFQNKIVDILLVAVILWIGVFIINRLVQLFFKRTD FIEEKKEKTIESLVRSVTQYTATIGFIFYVISLFVHDFGKILAGAGVAGIVIGFGAQS LIKDVLAGVFLIYERQLHKGDYVTVNNLFNGTVEEIGLRSLQIREWSGKLLTISNGEV RQIENYNIDFMRITESFLISFKEDPDRVYSVLEEACDMLNEELRDSLKRDEFGNPTEP FQIHGITALNKINRGVEFTVKGMVKDDDYFSASLAVRRVLVRQLYQNNVQMLEEAVRI ERTQ*" /label="mscC CDS" gene complement(791389..792231) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /label="mscC gene" downshifts complement(791391) /Source="Nicolas_upshifts" /id="D397" /incds=0 /nref=58 /ntot=230 /MaxReadThrough="1.96922" /MaxDrop="4.8789" /score="23.5281308" /energy="-9.8" /TU="NA" /idTUdmin="U609" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(792232..793353) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative Fe-S oxidoreductase, radical SAM superfamily" /protein_id="NP_388677.2" /db_xref="EnsemblGenomes-Gn:BSU07955" /db_xref="EnsemblGenomes-Tr:CAB12625" /db_xref="GOA:O34400" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014866" /db_xref="InterPro:IPR031004" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG12918" /db_xref="UniProtKB/Swiss-Prot:O34400" /translation="MTQNTKLRPITPEFDPWEAYMDVDQYGDMQLTNVEFTTTTLCNM RCEHCAVGYTLQPKDPNALPIDLLLKRLEEIPRLRSISITGGEPMLSLKSVKEYVVPL LKYAHERGVRTQINSNLTLDIERYEWIIPYLDVLHISHNWGTVEDFAEIGFAMMDRKP TFEQRARYFEKMIENSRTLVDAGVMVSAETMLNKRTLPHIEHIHRQITEDMKCQRHEV HPMYPSDFASALESLSLKEMRQAIHRLLDIRDENTWMLFGTLPFYACSPDEDDQKLLR RLRAAKNVTVRNDPDGRSRLNVNIFDGNIIVTDFGDTPPLGNIQTDSLPSAYEKWRET KLAKELSCHCPNVRCLGPNVLVKNSYYQDTDFTKRQARS*" /label="yfkA CDS" gene complement(792232..793353) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /label="yfkA gene" promotor_-10 complement(793394..793413) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(793412) /Source="Nicolas_upshifts" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(793429..793433) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 793441..793448 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 793462..793481 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 793472 /Source="Nicolas_upshifts" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="upshifts" CDS 793498..793683 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388678.1" /db_xref="EnsemblGenomes-Gn:BSU07970" /db_xref="EnsemblGenomes-Tr:CAB12626" /db_xref="SubtiList:BG12916" /db_xref="UniProtKB/Swiss-Prot:O35041" /translation="MGNAVNNKDQQIDYLKNRLDMFMNVIDSLDPEATDVEDIDRLIS MLDDLEAKYERFKKDWE*" /label="yfjT CDS" gene 793498..793683 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /label="yfjT gene" downshifts 793662 /Source="Nicolas_upshifts" /id="D398" /incds=0 /nref=15 /ntot=177 /MaxReadThrough="3.03457" /MaxDrop="3.24661" /score="14.1645187" /energy="-6.4" /TU="U610" /idTUdmin="U610" /TUdmin="-559" /isTUend="FALSE" /label="downshifts" promotor_-35 793726..793732 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 793738 /Source="Nicolas_upshifts" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 793747..793758 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 793784..794575 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported peptidoglycan N-acetylmuramic acid deacetylase" /protein_id="NP_388679.1" /db_xref="EnsemblGenomes-Gn:BSU07980" /db_xref="EnsemblGenomes-Tr:CAB12627" /db_xref="GOA:O34928" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014235" /db_xref="PDB:1NY1" /db_xref="PDB:1W17" /db_xref="PDB:1W1A" /db_xref="PDB:1W1B" /db_xref="SubtiList:BG12915" /db_xref="UniProtKB/Swiss-Prot:O34928" /translation="MKWMCSICCAAVLLAGGAAQAEAVPNEPINWGFKRSVNHQPPDA GKQLNSLIEKYDAFYLGNTKEKTIYLTFDNGYENGYTPKVLDVLKKHRVTGTFFVTGH FVKDQPQLIKRMSDEGHIIGNHSFHHPDLTTKTADQIQDELDSVNEEVYKITGKQDNL YLRPPRGVFSEYVLKETKRLGYQTVFWSVAFVDWKINNQKGKKYAYDHMIKQAHPGAI YLLHTVSRDNAEALDDAITDLKKQGYTFKSIDDLMFEKEMRLPSL*" /label="pdaA CDS" gene 793784..794575 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /label="pdaA gene" downshifts 794573 /Source="Nicolas_upshifts" /id="D399" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.12067" /MaxDrop="3.4013" /score="14.4741934" /energy="-10.2" /TU="NA" /idTUdmin="U611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(794613..795473) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative beta-hydroxyacid dehydrogenase" /protein_id="NP_388680.2" /db_xref="EnsemblGenomes-Gn:BSU07990" /db_xref="EnsemblGenomes-Tr:CAB12628" /db_xref="GOA:O34969" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12914" /db_xref="UniProtKB/Swiss-Prot:O34969" /translation="MKIAVIGLGNMGQPIARNVLQAGYELTVYNRTKQKTEDLVTEGA QAADTPRLAAKSADIVITMLADDDSVSTVTFGEDGLLEGLAENGIHISMSTISVEFSE KLAAAHAEKGQFFLAAPVLGRPDAAAKAALRIITAGPAEAKQAAKPLLDSLSQQIFDV GEESKTANAAKISINFLLVSMLEALSESFLMMEKYGLEQKQFLEIASALFGSPVYQNY GTIMAEQKFEPAGFKMSLGLKDTNLALAAAKRVSANLPLAELAKSHFESGIEKGFGDL DWAALIKCIK*" /label="yfjR CDS" gene complement(794613..795473) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /label="yfjR gene" downshifts complement(794627) /Source="Nicolas_upshifts" /id="D400" /incds=0 /nref=15 /ntot=193 /MaxReadThrough="2.61589" /MaxDrop="3.98341" /score="-1.3382901" /energy="-12.1" /TU="NA" /idTUdmin="U612" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(795493..795512) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(795507) /Source="Nicolas_upshifts" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(795528..795531) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(795572..796531) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563871, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="divalent cation (octahedral coordination) transporter" /protein_id="NP_388681.1" /db_xref="EnsemblGenomes-Gn:BSU08000" /db_xref="EnsemblGenomes-Tr:CAB12629" /db_xref="GOA:O31543" /db_xref="InterPro:IPR002523" /db_xref="InterPro:IPR004488" /db_xref="SubtiList:BG12913" /db_xref="UniProtKB/Swiss-Prot:O31543" /translation="MINITAITTEHQLLKNIPIERVEQPDIAWYWVDFYGPEDTETAL LRDFFHFHPLAIEDCFQHMQRPKLDHYDGYRFYVIHALNKETLETEEVDIFQGEKFVV TFHLHETPGIAKVRERLYASPDILKKGPGHISYMIMDQLVDEYFPLVYKIEDRLNEIE ESRPHKTYGTLMNEVFDLRTDLLHLRRTIIPMRDLLYRILSLDHVKEQRETKAYFSDI YDHLLKLSEIVESNRDMTSDLRDSYVTLNSNRMNAIMMTLTIVSTIFIPLTFIAGVYG MNFDFMPELHWKYGYFAVLGLMAALVIGMLIWFVHKGWFNIFK*" /label="yfjQ CDS" gene complement(795572..796531) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /label="yfjQ gene" downshifts complement(795595) /Source="Nicolas_upshifts" /id="D401" /incds=0 /nref=137 /ntot=224 /MaxReadThrough="2.29296" /MaxDrop="4.2496" /score="10.2736001" /energy="-7.5" /TU="NA" /idTUdmin="U613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(796542..796561) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(796545) /Source="Nicolas_upshifts" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(796577..796580) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 796592..796596 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 796610..796629 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 796619 /Source="Nicolas_upshifts" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="upshifts" CDS 796650..797513 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /EC_number="3.2.2.21" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA-3-methyladenine glycosylase" /protein_id="NP_388682.1" /db_xref="EnsemblGenomes-Gn:BSU08010" /db_xref="EnsemblGenomes-Tr:CAB12630" /db_xref="GOA:O31544" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG12912" /db_xref="UniProtKB/Swiss-Prot:O31544" /translation="MWKEKVSVTPPYHFDRVLDRLSLDPLNAVDREAREVRVPIRNQA GDVCIVKVQALGHAGEPEFLVSGETDQGEMMKEIKRIFQWENHLQHVLDHFSKTSLSA IFEEHAGTPLVLDYSVYNCMMKCIIHQQLNLSFAYTLTERFVHAFGEQKDGVWCYPKP ETIAELDYQDLRDLQFSMRKAEYTIDTSRMIAEGTLSLSELPHMADEDIMKKLIKIRG IGPWTVQNVLMFGLGRPNLFPLADIGLQNAIKRHFQLDDKPAKDVMLAMSKEWEPYLS YASLYLWRSIE*" /label="yfjP CDS" gene 796650..797513 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /label="yfjP gene" S_feature 797514..797626 /Source="Nicolas_S_feature" /locus_tag="new_873289_873401" /HighExp="BC, M40t90, LBGtran, C90, M9-stat, M0t90, Lbtran, Sw, M40t45, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S277" CDS 797627..799027 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methyltransferase" /protein_id="NP_388683.1" /db_xref="EnsemblGenomes-Gn:BSU08020" /db_xref="EnsemblGenomes-Tr:CAB12631" /db_xref="GOA:O31545" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12911" /db_xref="UniProtKB/Swiss-Prot:O31545" /translation="MNQQKKQAPVELKVGQTFPLTIKRLGINGEGVGYFKKKVVFVPG ALPGEEVVVQATKVQPKFSEGRIKKIRKASEHRVAPPCPVYEQCGGCQLQHLAYSQQL REKRDIVIQSLERHTKFKVENMEIKETIGMDNPWNYRNKSQFQIGRSQSGSIIAGLYG LDSHDIVPIKDCIVQHPATNKTTGIVRRILEDFNVSVYNERKRKGDVRTIVTRVGFET GEVQVVLVTAKETLPHKEEIVKAIQKRLPEVKSIIQNVNGAKTSVIFGEKTKQLAGKT VIQEVLGDVSFELSARAFFQLNPEQTVKLYDEVKKAAQLTGKEKVVDAYCGVGTIGMW VADGAKEVRGMDVIKESIDDAKKNAKKHGMANATYVTGTAEHWLPKWTKEGFRPDVVI VDPPRTGCDSTFLDTIKKVKPKRFVYVSCNPSTLAKDLQTLSKDYRVDYIQPVDMFPQ TAHVEAVARLVLKSSN*" /label="yfjO CDS" gene 797627..799027 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /label="yfjO gene" downshifts 799039 /Source="Nicolas_upshifts" /id="D402" /incds=0 /nref=198 /ntot=251 /MaxReadThrough="1.18186" /MaxDrop="5.19313" /score="11.8630961" /energy="-12.6" /TU="NA" /idTUdmin="U614" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 799333..799340 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 799356..799375 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 799362 /Source="Nicolas_upshifts" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="upshifts" S_feature 799369..799652 /Source="Nicolas_S_feature" /locus_tag="new_875144_875427" /HighExp="M9-stat, T1.30H, T0.30H, T2.0H, LoTm, T3.0H, T3.30H, T1.0H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69102300000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S278" CDS 799653..799919 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097694.1" /db_xref="EnsemblGenomes-Gn:BSU08029" /db_xref="EnsemblGenomes-Tr:CAX52581" /db_xref="GOA:C0H3X6" /db_xref="InterPro:IPR025627" /db_xref="UniProtKB/Swiss-Prot:C0H3X6" /translation="MDKVYKRSWFQTFLAFLVSQLYFNFVELTGWGPKYREMNGFPAN IVELDFFQTYLSFYDNPWFNIITVFLGVFTIIQIITGITKDIRN*" /label="yfzA CDS" gene 799653..799919 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /label="yfzA gene" promotor_-10 complement(799867..799886) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(799885) /Source="Nicolas_upshifts" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(799901..799904) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 799920..800401 /Source="Nicolas_S_feature" /locus_tag="new_875695_876176" /HighExp="G180, Paraq, H2O2, G135, Oxctl, G150, C30, LoTm, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S279" promotor_-35 800372..800375 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 800392..800411 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 800403..800650 /Source="Nicolas_S_feature" /locus_tag="new_876178_876425" /HighExp="H2O2, G180, Paraq, G150, G135, Oxctl, dia15, LBGstat, LBGexp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S280" upshifts 800403 /Source="Nicolas_upshifts" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 800651..801628 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /EC_number="1.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 25902496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase 2" /protein_id="NP_388684.1" /db_xref="EnsemblGenomes-Gn:BSU08030" /db_xref="EnsemblGenomes-Tr:CAB12632" /db_xref="GOA:O31546" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG12910" /db_xref="UniProtKB/Swiss-Prot:O31546" /translation="MTENFWRELPRPFFVLAPMEDVTDVVFRHVVSEAGRPDVFFTEF TNSESYCHPDGKDSVRGRLTFTEDEQPIVAHIWGDKPENFRKMSIGMAELGFKGLDIN MGCPVPNVAGNGKGSGLICRPAVAAELIQAAKAGGLPVSVKTRLGYTDVDEWREWLTH ILKQDIANLSIHLRTRAEMSKVDAHWELIPEIKKLRDEVAPDTLLTINGDIPDRQTGL KLAEQYGVDGIMIGRGIFTNPFAFEKEPKEHSSKELLDLLRLHLDLHDEYSKEEARPY KPLPRFFKIYLRGFRGASELRNQCMNTKSTDEVRALLDDFERKYLDGIE*" /label="dusC CDS" gene 800651..801628 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /label="dusC gene" S_feature 801629..801721 /Source="Nicolas_S_feature" /locus_tag="new_877404_877496" /HighExp="G135, G180, Paraq, G150, H2O2, LBGexp, aero, dia0, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S281" downshifts 801678 /Source="Nicolas_upshifts" /id="D403" /incds=0 /nref=86 /ntot=218 /MaxReadThrough="3.30163" /MaxDrop="4.0519" /score="11.8630961" /energy="-12.6" /TU="U617" /idTUdmin="U618" /TUdmin="-1211" /isTUend="FALSE" /label="downshifts" promotor_-35 801762..801768 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 801780..801799 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 801789 /Source="Nicolas_upshifts" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 801824..802276 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388685.1" /db_xref="EnsemblGenomes-Gn:BSU08040" /db_xref="EnsemblGenomes-Tr:CAB12633" /db_xref="SubtiList:BG12909" /db_xref="UniProtKB/Swiss-Prot:O31547" /translation="MKRLCIIPCGKKKIWDVQPDAGPVRAEDAYLSPFHQACERYAKT FFDEWVILSAKHGFLRPDDLVSGNYDVTFGTGHPEIMTADELRRQFHEKGFSDIEELV MLGGKKYRSVLNAVIGEHQHISWPLSSYKGIGYMLQALNRAVEEKHEL*" /label="yfjM CDS" gene 801824..802276 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /label="yfjM gene" CDS 802306..802995 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388686.1" /db_xref="EnsemblGenomes-Gn:BSU08050" /db_xref="EnsemblGenomes-Tr:CAB12634" /db_xref="InterPro:IPR020523" /db_xref="SubtiList:BG11034" /db_xref="UniProtKB/Swiss-Prot:P40773" /translation="MKKLVFGLLAIVLFGCGLYIYHVWFGDPFSKNAAEQKLVSYVKQ TYPKKEIKITNGVYNAKTSEYVFEATSQSHRYPMCTKGFLHPKVTCDGIEEAYTESVA KHVNEEATKAIEADLKKAVPRFIKADAALSIENGQFTLDTKWNKKLAEKAPMSMTIQL DASGLSKTDAAKMAETVRKTLNEKGYTYSNGTIDCMQKDGDGGIGYVKYSIDFLSKAA IQSNDAEELGS*" /label="yfjL CDS" gene 802306..802995 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /label="yfjL gene" downshifts 803000 /Source="Nicolas_upshifts" /id="D404" /incds=0 /nref=31 /ntot=205 /MaxReadThrough="0.02745" /MaxDrop="3.61164" /score="23.9796437" /energy="-9" /TU="NA" /idTUdmin="U617" /TUdmin=1 /isTUend="TRUE" /label="downshifts" misc_feature 803172..803190 /Source="Nicolas_upshift_promotors" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 803179 /Source="Nicolas_upshifts" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 803227..804228 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109, 22714279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109, 22714279; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent alpha subunit)" /protein_id="NP_388687.1" /db_xref="EnsemblGenomes-Gn:BSU08060" /db_xref="EnsemblGenomes-Tr:CAB12635" /db_xref="GOA:O31404" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12558" /db_xref="UniProtKB/Swiss-Prot:O31404" /translation="MKLLKREGLSLTEEKALWMYQKMLEIRGFEDKVHELFAQGVLPG FVHLYAGEEAVAVGVCAHLHDGDSITSTHRGHGHCIAKGCDLDGMMAEIFGKATGLCK GKGGSMHIADLDKGMLGANGIVGGGFTLACGSALTAKYKQTKNVSVCFFGDGANNQGT FHEGLNLAAVWNLPVVFVAENNGYGEATPFEYASACDSIADRAAAYNMPGVTVDGKDI LAVYQAAEEAIERARNGGGPSLIECMTYRNYGHFEGDAQTYKTKDERVEHLEEKDAIQ GFKNYLLKETDANKLSDIEQRVSESIEKAVSFSEDSPYPKDSELLTDVYVSYEKGGM* " /label="acoA CDS" gene 803227..804228 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /label="acoA gene" CDS 804232..805260 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 10368162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 10368162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent beta subunit)" /protein_id="NP_388688.1" /db_xref="EnsemblGenomes-Gn:BSU08070" /db_xref="EnsemblGenomes-Tr:CAB12636" /db_xref="GOA:O34591" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG12559" /db_xref="UniProtKB/Swiss-Prot:O34591" /translation="MARVISMSDAINEAMKLAMRKDENVLLIGEDVAGGAAVDHLQDD EAWGGVLGVTKGLVQEFGRTRVLDTPISEAGYMGAAMAAASTGLRPIAELMFNDFIGT CFDQVINQGAKFRYMFGGKAQVPITVRTTYGAGFRAAAQHSQSLYGLFTSIPGLKTVV PSNPYDAKGLLLAAIEDNDPVFFFEDKTSYNMKGEVPEDYYTIPLGKADIKREGNDVT LFAVGKQVNTALEAAAQLSERGIEAEVLDPRSLSPLDEDAIFTSLEKTNRLIIIDEAN PRCSIATDIAALVADKGFDLLDAPIKRITAPHTPVPFSPVLEDQYLPTPDKIVSVTLE LLGEPALN*" /label="acoB CDS" gene 804232..805260 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /label="acoB gene" CDS 805274..806470 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /EC_number="2.3.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E2 component (dihydrolipoamide acetyltransferase)" /protein_id="NP_388689.1" /db_xref="EnsemblGenomes-Gn:BSU08080" /db_xref="EnsemblGenomes-Tr:CAB12637" /db_xref="GOA:O31550" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG12560" /db_xref="UniProtKB/Swiss-Prot:O31550" /translation="MAVKVVMPKLGMAMKQGEVSIWNKKVGDPVEKGESIASIQSEKI EMEIEAPEKGTLIDIKVKEGEEVPPGTAICYIGDANESVQEEAGAPVAEDNMPQAVQP VKQENKPAASKKDRMKISPVARKIAEKAGLDLKQLKGTGPGGRIVKDDVTKALAEQKK DQAKPVSEQKAQEIPVTGMRKVIAARMQESLANSAQLTITMKADITKLATLQKQLSPT AEERYGTKLTITHFVSRAAVLALQAHPVLNSFYQNERIITHPHVHLGMAVALENGLVV PVIRHAEKLSLIELAQSISENAKKAREGRAGSEELQGSTFSITNLGAFGVEHFTPILN PPETGILGIGASYDTPVYQGEEIVRSTILPLSLTFDHRACDGAPAAAFLKAMKTYLEE PAALIL*" /label="acoC CDS" gene 805274..806470 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /label="acoC gene" downshifts complement(805275) /Source="Nicolas_upshifts" /id="D405" /incds=0 /nref=8 /ntot=46 /MaxReadThrough="0.481579999999999" /MaxDrop="4.16582" /score="-0.0231058321" /energy="-9.9" /TU="NA" /idTUdmin="U623" /TUdmin=4796 /isTUend="FALSE" /label="downshifts" CDS 806491..807867 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /EC_number="1.8.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase)" /protein_id="NP_388690.1" /db_xref="EnsemblGenomes-Gn:BSU08090" /db_xref="EnsemblGenomes-Tr:CAB12638" /db_xref="GOA:O34324" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12561" /db_xref="UniProtKB/Swiss-Prot:O34324" /translation="MTLAIIGGGPAGYAAAVSAAQQGRNVLLIDKGKLGGTCLNEGCI PTKSLLESANVLDKIKHADSFGIELPAGAISVDWSKMQSRKQQVVSQLVQGVQYLMKK NQIQVVKGTASFLSERKLLIEGENGKEIREADQVLIASGSEPIELPFAPFDGEWILDS KDALSLSEIPSSLVIVGGGVIGCEYAGLFARLGSQVTIIETADRLIPAEDEDIARLFQ EKLEEDGVEVHTSSRLGRVDQTAKTAIWKSGQREFKTKADYVLVAIGRKPRLDGLQLE QAGVDFSPKGIPVNGHMQTNVPHIYACGDAIGGIQLAHAAFHEGIIAASHASGRDVKI NEKHVPRCIYTSPEIACIGMTERQARSIYGDVKIGEFSFSANGKALIKQQAEGKVKIM AEPEFGEIVGVSMIGPDVTELIGQAAAIMNGEMTADMAEHFIAAHPTLSETLHEALLS TIGLAVHA*" /label="acoL CDS" gene 806491..807867 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /label="acoL gene" downshifts 807861 /Source="Nicolas_upshifts" /id="D406" /incds=0 /nref=27 /ntot=56 /MaxReadThrough="5.75671" /MaxDrop="5.6153" /score="27.0133719" /energy="-14.7" /TU="U619" /idTUdmin="U619" /TUdmin="-2156" /isTUend="FALSE" /label="downshifts" promotor_-35 807914..807921 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 807934..807953 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 807942 /Source="Nicolas_upshifts" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 807983..809800 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /experiment="publication(s) with functional evidences, PMID:11274109, 16944132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 16944132; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AcoR-acetoin)" /protein_id="NP_388691.1" /db_xref="EnsemblGenomes-Gn:BSU08100" /db_xref="EnsemblGenomes-Tr:CAB12639" /db_xref="GOA:O31551" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG11790" /db_xref="UniProtKB/Swiss-Prot:O31551" /translation="MNSVPNDLQTWKRFVKDGVLDEARLRKRIAESWHRCKKAEVNPY LEKGPKVLQQTELDQQSKKHSFFLTTAKPYLEKLLPAIKEMEMMALLIDSDGVVLALD GHPRALYEAKRINFVEGACWTETAVGTNAIGTALHISEPVAIQGSEHYSIASHLWNCS AAPIHHEDGSLAGVIDISCPAAGAHPHMLGIATAIAYAAERELAAKSREKELELISRF GERAASSVPMVLCNTKQHIISASMPIRTSMPDWQGRHLYELKERGYSIENAVTIGDGG TCFYLSEQKKKKAFRFNGVIGQSGRSQAMLMHLERAAATDASVCLSGETGTGKEVAAR ALHENSERRHGPFVAVNCGAIPSDLIESELFGYAEGAFTGAKRNGYKGAFQKANQGTL FLDEIGEISHSMQVALLRVLQERKITPIGGTKEIPVDIRVIAATHCDLRELAENGKIR EDLFYRLHVYPIELPPLRDRTEDIPDLFEYYKQKNHWPGDLPSDFCNVLKQWKWPGNI RELFNVFERLSIRFPDGRLRDESLPALLEAAGLPASSAEKKPAAAGVLTFREQIQKDM MIKALESAKGNVSQAAKISGIPRSTFYKRLKKFNLSAES*" /label="acoR CDS" gene 807983..809800 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /label="acoR gene" promotor_-35 809801..809807 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 809819 /Source="Nicolas_upshifts" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 809822..809833 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 809854..810033 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_388692.1" /db_xref="EnsemblGenomes-Gn:BSU08110" /db_xref="EnsemblGenomes-Tr:CAB12640" /db_xref="GOA:O31552" /db_xref="InterPro:IPR012610" /db_xref="SubtiList:BG12917" /db_xref="UniProtKB/Swiss-Prot:O31552" /translation="MNIQRAKEIVESPDMKKVTYNGVPIYIQHVNEETGTARIYPLDE PQEEHEVQLNSLKED*" /label="sspH CDS" gene 809854..810033 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /label="sspH gene" downshifts 810017 /Source="Nicolas_upshifts" /id="D407" /incds=0 /nref=96 /ntot=181 /MaxReadThrough="1.9176" /MaxDrop="6.06509" /score="5.08326573" /energy="-12" /TU="NA" /idTUdmin="U619" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(810069..810398) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388693.1" /db_xref="EnsemblGenomes-Gn:BSU08120" /db_xref="EnsemblGenomes-Tr:CAB12641" /db_xref="GOA:O31553" /db_xref="InterPro:IPR003844" /db_xref="SubtiList:BG12908" /db_xref="UniProtKB/Swiss-Prot:O31553" /translation="MMLITILLFLAAGLAEIGGGYLVWLWLREAKPAGYGIAGALILI VYGILPTFQSFPSFGRVYAAYGGVFIVLAVLWGWLVDRKTPDLYDWIGAFICLIGVCV ILFAPRG*" /label="yfjF CDS" gene complement(810069..810398) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /label="yfjF gene" downshifts complement(810083) /Source="Nicolas_upshifts" /id="D408" /incds=0 /nref=96 /ntot=245 /MaxReadThrough="2.05328" /MaxDrop="6.2642" /score="34.1179702" /energy="-15.8" /TU="NA" /idTUdmin="U623" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(810448..810906) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388694.1" /db_xref="EnsemblGenomes-Gn:BSU08130" /db_xref="EnsemblGenomes-Tr:CAB12642" /db_xref="GOA:O31554" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12907" /db_xref="UniProtKB/Swiss-Prot:O31554" /translation="MSEALTFESKYALLYLGGGLLAMIYGLITFFMAFPAFTSRGNVI FTIKTGPSGEIFLRKRSVLFSEVKRLYMGRHQYSLKGIFFEDIIIEKTDGKIVRIPTW NIITNPLFFEAVERYILPHLNEEAQNNWISQFTEVQRKAYLKEFENHPKL*" /label="yfjE CDS" gene complement(810448..810906) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /label="yfjE gene" S_feature complement(810907..810999) /Source="Nicolas_S_feature" /locus_tag="new_886682_886774_c" /HighExp="BI, BC, S2, Sw, HiOs, HiTm, S5, ferm, S4, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S282" CDS complement(811000..811557) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388695.1" /db_xref="EnsemblGenomes-Gn:BSU08140" /db_xref="EnsemblGenomes-Tr:CAB12643" /db_xref="GOA:O31555" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12906" /db_xref="UniProtKB/Swiss-Prot:O31555" /translation="MKNQEIIEVKSKMFLRIWAFVGSAGMGLACLWLFYMGITFQTKY YLLAIPAGFLFTLFCLYLFIIFFPAFTPRGNTIFRIKTGKNGEVFTDKVSVTFTDIKK IEMSRHKFSLKGIFQEDILIQTVDQKTIRIPTWNIIPNPLFFEAVERYILPHLNEEAK SNWIGQFTDIQRSAYLKEFENHPKL*" /label="yfjD CDS" gene complement(811000..811557) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /label="yfjD gene" promotor_-35 811423..811428 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 811436 /Source="Nicolas_upshifts" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 811443..811461 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 811447..812034 /Source="Nicolas_S_feature" /locus_tag="new_887222_887809" /HighExp="S4, S5, S6, S3, S8, S7, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="yfjC" /AntisenseCor="9.3643586039105595E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S283" CDS complement(811589..812356) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388696.1" /db_xref="EnsemblGenomes-Gn:BSU08150" /db_xref="EnsemblGenomes-Tr:CAB12644" /db_xref="SubtiList:BG12905" /db_xref="UniProtKB/Swiss-Prot:O31556" /translation="MKQFTISIEELLFCFYSEGFFEQGMALKQAYFPEIEDEQLGALF EAACRSLLAKDAAEYRNHQYRLKDEYCPFIHVLNDADYTVKLSKFNGQGAEQNVSCHV SKFGTYSHELLFDEQVHRITKMESSEGLLAKTDEFLHIIDTEDKRESIVTLTSNEFEK LLEGASDNPSYLKEFLEKHDHQEDVTRFANDLALRKGKMDTLMRLAYGKDNTPEVADM AFVLPGAHHTWLVTGITQNEFSILPAHKDVVNQIISK*" /label="yfjC CDS" gene complement(811589..812356) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /label="yfjC gene" CDS complement(812368..813591) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388697.1" /db_xref="EnsemblGenomes-Gn:BSU08160" /db_xref="EnsemblGenomes-Tr:CAB12645" /db_xref="SubtiList:BG12904" /db_xref="UniProtKB/Swiss-Prot:O31557" /translation="MSGNIAVDPDKLEQLANDVVTELTDMENKYKDLHVELGQMILQC DPRYSSCFSGVGDAWSSGKALVTKLSDNEIFIRKTGDKFVEQDDILRKLYNAYDKYGT MTSLTALMLTQGKYYGLGLTKFVKQPSGLHTAQHSKLLLDISRAVDSSRYQKAARVLL NPKYLLKKTNRPFSDLVHKKFTKYFPQDTVDFSNSVRSYTKGFLNEAGVRSTLKDVGK TGLRFAKGNAITATLITGATETFGAGVKIAENYAKYQDKPEVLKRENAKAVGNAVNNT IFVAGGATAGAVIGGAIGSFAGPVGTVLLGAAGSYIGGVVGEQIAKYTAGFAEKAALK LKEPIHAVVDTAKKGLESAGKVVKSVNDGIDAANKSIHKGIDSAKKGMEKAKKTADSL IHGATHFLKGKFSFG*" /label="yfjB CDS" gene complement(812368..813591) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /label="yfjB gene" CDS complement(813597..813911) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388698.1" /db_xref="EnsemblGenomes-Gn:BSU08170" /db_xref="EnsemblGenomes-Tr:CAB12646" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12903" /db_xref="UniProtKB/Swiss-Prot:O31558" /translation="MDSYKVIELANKYSAAAEEVRSSKMLLESRLSALGDAWQGKARD SFDQDFEETKAAYDQFEQELLETSQELKAAAVKIEERKAEIARMEELERKAREERHKL GR*" /label="yfjA CDS" gene complement(813597..813911) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /label="yfjA gene" promotor_-10 complement(813959..813978) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(813972) /Source="Nicolas_upshifts" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(813993..813996) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 814203..814222 /Source="Nicolas_upshift_promotors" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 814206 /Source="Nicolas_upshifts" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="upshifts" CDS 814247..815596 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /EC_number="3.2.1.122" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-alpha-glucosidase" /protein_id="NP_388699.1" /db_xref="EnsemblGenomes-Gn:BSU08180" /db_xref="EnsemblGenomes-Tr:CAB12647" /db_xref="GOA:P54716" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:1U8X" /db_xref="SubtiList:BG11839" /db_xref="UniProtKB/Swiss-Prot:P54716" /translation="MKKKSFSIVIAGGGSTFTPGIVLMLLDHLEEFPIRKLKLYDNDK ERQDRIAGACDVFIREKAPDIEFAATTDPEEAFTDVDFVMAHIRVGKYAMRALDEQIP LKYGVVGQETCGPGGIAYGMRSIGGVLEILDYMEKYSPDAWMLNYSNPAAIVAEATRR LRPNSKILNICDMPVGIEDRMAQILGLSSRKEMKVRYYGLNHFGWWTSIQDQEGNDLM PKLKEHVSQYGYIPKTEAEAVEASWNDTFAKARDVQAADPDTLPNTYLQYYLFPDDMV KKSNPNHTRANEVMEGREAFIFSQCDMITREQSSENSEIKIDDHASYIVDLARAIAYN TGERMLLIVENNGAIANFDPTAMVEVPCIVGSNGPEPITVGTIPQFQKGLMEQQVSVE KLTVEAWAEKSFQKLWQALILSKTVPNARVARLILEDLVEANKDFWPELDQSPTRIS* " /label="malA CDS" gene 814247..815596 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /label="malA gene" misc_feature 815625..815644 /Source="Nicolas_upshift_promotors" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 815627 /Source="Nicolas_upshifts" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="upshifts" CDS 815661..816425 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489864, 16707683, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489864, 16707683, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the Mal operon" /protein_id="NP_388700.1" /db_xref="EnsemblGenomes-Gn:BSU08190" /db_xref="EnsemblGenomes-Tr:CAB12648" /db_xref="GOA:P54717" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11847" /db_xref="UniProtKB/Swiss-Prot:P54717" /translation="MQLEELINQHYSKLNDNDFHILKYILNHKHTCYHLGIDALAKAC SVSRSSILRLAQKLGFSGYSEFRVFLKWEDQPEEGESMSFEKLLDDIEANLKFLRTKD MTDMCQLIDAADRIFVYGSGNAQKICARDLQRMFIPRHRYLILIEDTNEFNLMRDDFK VNDLFIIISLSGETPELIPQARMLSAKGIPFISITNLKNNVLAQLTPHNLYATSKPVT LSDRTEIVAFAPFFLVGEALFRAYVDYKEAEKNDNE*" /label="malR CDS" gene 815661..816425 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /label="malR gene" promotor_-10 complement(815805..815819) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(815835..815841) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(815835) /Source="Nicolas_upshifts" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 816440..818023 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) maltose-specificenzyme IICB component" /protein_id="NP_388701.1" /db_xref="EnsemblGenomes-Gn:BSU08200" /db_xref="EnsemblGenomes-Tr:CAB12649" /db_xref="GOA:P54715" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010975" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11848" /db_xref="UniProtKB/Swiss-Prot:P54715" /translation="MMQKIQRFGSAMFVPVLLFAFAGIIVGISTLFKNKTLMGPLADP DGFWYQCWYIIEQGGWTVFNQMPLLFAIGIPVALAKKAQARACLEALTVYLTFNYFVS AILTVWGGAFGVDMNQEVGGTSGLTMIAGIKTLDTNIIGAIFISSIVVFLHNRYFDKK LPDFLGIFQGSTYIVMISFFIMIPIALAVSYIWPMVQSGIGSLQSFLVASGAVGVWIY TFLERILIPTGLHHFIYTPFIYGPAVAEGGIVTYWAQHLGEYSQSAKPLKELFPQGGF ALHGNSKIFGIPGIALAFYVTAKKEKKKLVAGLLIPVTLTAIVAGITEPIEFTFLFIS PFLFAVHAVLAATMSTVMYMAGVVGNMGGGLIEAVTLNWIPLFGSHGMTYVYQILIGL SFTAIYFFVFRFLILKFNIATPGREKDEQQETKLYSKKEYRERKNKDETASAAETADD TAFLYIEALGGKDNITEVTNCATRLRVSVKDETKVEPDSVFRALGAHGVVRNGKAFQV IIGLSVPQMRERVEKILNQ*" /label="malP CDS" gene 816440..818023 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /label="malP gene" downshifts 818003 /Source="Nicolas_upshifts" /id="D409" /incds=0 /nref=23 /ntot=46 /MaxReadThrough="3.26652" /MaxDrop="4.69656" /score="8.65399085" /energy="-10.9" /TU="U624" /idTUdmin="U625" /TUdmin=836 /isTUend="FALSE" /label="downshifts" promotor_-35 818052..818059 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 818074..818093 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 818082 /Source="Nicolas_upshifts" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="upshifts" CDS 818129..819850 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative xenobiotic ABC transporter subunit (ATP-binding protein)" /protein_id="NP_388702.1" /db_xref="EnsemblGenomes-Gn:BSU08210" /db_xref="EnsemblGenomes-Tr:CAB12650" /db_xref="GOA:P54718" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11849" /db_xref="UniProtKB/Swiss-Prot:P54718" /translation="MQKALSFLKPYSLLAGIALILMLTELAVELMQPLLIAKIIDDGI LKQDLRHVWIWGTVMIGLTVLSFAAGMLNSFYAAHVSQSFSYDTRKGLFQKIQSFSYS TFGQFSSSSYITRLTNDVTQVQNMIFMSLRFMLRAPLMIAGGIVLSLAVNVKLGFFLL VTIPILILFLLWVLRKGGALFRSVQKRLDQVNTIMQENLIAIKLIKALLRGSHEVKRF IKANTRLMEKTVSAFQLVEFTMPVLMLLMNLCILLILWAGSYSITSGSTQVGDVVAII NYATRITGALSMFPFLIMIFTRAKASGDRIGEVLETEGDEREEGTISDRLSGRIEFQH VSFRYPEMDREALRNVSFSAKPRETIAILGATGSGKSTLFQLIPRLYQPDSGRIYIDE KPVQDIPAEGLRRQIGYVPQEVLLFSGTIKENIAWGKENASLDEIMDAAKLAQIHETI LKLPNGYDTVLGQRGVNLSGGQKQRISIARALIRKPAILLLDDSTSALDLQTEAKLLE AISTYHCTTLIITQKITTAMKADQILLLEDGELIEKGTHSELLSESQLYKRIYESQFG REGSESC*" /label="yfiB CDS" gene 818129..819850 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /label="yfiB gene" CDS 819844..821658 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388703.1" /db_xref="EnsemblGenomes-Gn:BSU08220" /db_xref="EnsemblGenomes-Tr:CAB12651" /db_xref="GOA:P54719" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11850" /db_xref="UniProtKB/Swiss-Prot:P54719" /translation="MLKDIRKPFQYPKLPIDKKEGAKKRAKAKDTKGTLRRIWSYLAE RKGLLILVMLMVVISAIFGLLGPFVIGKAIDHFIVGKTVSGLIPVLLLLLAIYIIQSL SLWFQNYWMITISQGTVFRMRSELFTHLHELPIPFFDKQRHGELMSRVTNDIENVSST LNTSVIQILSSVITFVGTIAVMLYMSPLLTLITLTIIPVMAASLKWITNRTGKLFKEQ QKNLGDLNGYIEESVSGAKVIKAYSREKQITAEFLEKNAALKTSGFWAQTISGFIPKV MNSLNNLSFTMIAAIGGLFALKGWISIGSIVVFAEYSRQFTRPLNDLANQFNTMLSAI AGAERVFDVLDEKEEREDEKNAVHQPIQTGSIEFRDVSFGYDKGQQTLKHLQFTVPAG QSIAFVGPTGAGKTTVTNLLARFYEPNDGKILIDGTDIKTLTRASLRKNMGFVLQDSF LFQGTIRENIRYGRLDASDQEVEAAAKTANAHSFIERLPKGYDTVLTQNGSGISQGQK QLISIARAVLADPVLLILDEATSNIDTVTEVNIQEALARLMEGRTSVIIAHRLNTIQR ADQIVVLKNGEMIEKGSHDELIRQKGFYSDLYESQFEK*" /label="yfiC CDS" gene 819844..821658 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /label="yfiC gene" downshifts 821633 /Source="Nicolas_upshifts" /id="D410" /incds=0 /nref=103 /ntot=190 /MaxReadThrough="2.4559" /MaxDrop="5.61906" /score="24.4395842" /energy="-11" /TU="NA" /idTUdmin="U627" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 821740..821747 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 821761..821780 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 821765 /Source="Nicolas_upshifts" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="upshifts" CDS 821813..822217 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16872404, 16850406, 17407181, 20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16872404, 16850406, 17407181, 20639328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase membrane subunit" /protein_id="NP_388704.1" /db_xref="EnsemblGenomes-Gn:BSU08230" /db_xref="EnsemblGenomes-Tr:CAB12652" /db_xref="GOA:P54720" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG11851" /db_xref="UniProtKB/Swiss-Prot:P54720" /translation="MNKSFEIGTLLLRVITGIIFFVHGLSKFQGMEGTIQFFGSIGLP SFMAYVIAAIELIGGVLVFFGLATRIVGVLFALTLIGAIITVKLKAPFMGNAEFDYLL LLTSIHLALTGSRFLALDPFVFKGKKNGNVSA*" /label="catD CDS" gene 821813..822217 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /label="catD gene" CDS 822235..823092 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17407181, 16872404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 16872404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase subunit" /protein_id="NP_388705.2" /db_xref="EnsemblGenomes-Gn:BSU08240" /db_xref="EnsemblGenomes-Tr:CAB12653" /db_xref="GOA:P54721" /db_xref="InterPro:IPR000486" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11852" /db_xref="UniProtKB/Swiss-Prot:P54721" /translation="MTSIHEDTHIGYAKLTIRSLERSLQFYCNVIGFQVLKKTDRQAE LTADGKRVLLILEENPSAVVLPERSVTGLYHFAILLPDRKELGIALARLIEHGIAIGH GDHAVSEALYLSDPDGNGIEMYADRPRSTWQRDREGNYVMTTTAVDIEGLLEEAGDER KTSLPNDTIIGHIHLHVSDLKEAKAFYTDVLGFDIVGNYAGMSALFVSAGGYHHHIGL NIWAGRNAPPKPTNASGLDYYTVVLPHQEELDLVANRVKHAGYSIEETENSFRVKDPV SGAYITFVI*" /label="catE CDS" gene 822235..823092 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /label="catE gene" downshifts 823079 /Source="Nicolas_upshifts" /id="D411" /incds=0 /nref=4 /ntot=21 /MaxReadThrough="0.66359" /MaxDrop="3.74886" /score="50.8573531" /energy="-19.7" /TU="NA" /idTUdmin="U628" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS 823186..824130 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family; cupin family)" /protein_id="NP_388706.1" /db_xref="EnsemblGenomes-Gn:BSU08250" /db_xref="EnsemblGenomes-Tr:CAB12654" /db_xref="GOA:P54722" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11853" /db_xref="UniProtKB/Swiss-Prot:P54722" /translation="MELNHLVTGKIALNQYVHRLEQKDVSFYVHYWGAMTNHYNTLLH KHSFYEICYVVRGEGYYLEGDRTYPLREQTIFLSKPEHLHQIKSETGLFLFYVAFELS EDQSSAEWIKVMEEVKQSPFITMQLKDGEPPGLLWKTLMLQAAQPVNAFDKEILSHLS HALILSLIQTFLPYAQRPKQKQPIHTSSALLTEVKLHIKDNLSQPLKLTDVASHFHIS GRHLSRLFAAELGVSYSEFVQNEKINKAAELLKSTNLSIKEIAEEIGFSVHYFTRVFS AKIGSSPGLFRSLYKDSKMTAFQINKPFQKIEQAKPHE*" /label="yfiF CDS" gene 823186..824130 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /label="yfiF gene" downshifts complement(823997) /Source="Nicolas_upshifts" /id="D412" /incds=1 /nref=1 /ntot=2 /MaxReadThrough="-0.20031" /MaxDrop="3.51831" /score="-4.19869956" /energy="-9.5" /TU="NA" /idTUdmin="U632" /TUdmin=9372 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(824045..824145) /Source="Nicolas_upshift_promotors" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(824085) /Source="Nicolas_upshifts" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 824305..825753 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar/proton transporter" /protein_id="NP_388707.1" /db_xref="EnsemblGenomes-Gn:BSU08260" /db_xref="EnsemblGenomes-Tr:CAB12655" /db_xref="GOA:P54723" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11854" /db_xref="UniProtKB/Swiss-Prot:P54723" /translation="MSTKKKEAVIGKESLAHKGLLRTITLVSTFGGLLFGYDTGVING ALPFMATAGQLNLTPVTEGLVASSLLLGAAFGAMFGGRLSDRHGRRKTILYLALLFIA ATLGCTFSPNASVMIAFRFLLGLAVGCASVTVPTFLAEISPAERRGRIVTQNELMIVI GQLLAYTFNAIIGSTMGESANVWRYMLVIATLPAVVLWFGMLIVPESPRWLAAKGRMG DALRVLRQIREDSQAQQEIKEIKHAIEGTAKKAGFHDFQEPWIRRILFIGIGIAIVQQ ITGVNSIMYYGTEILREAGFQTEAALIGNIANGVISVIAVIFGIWLLGKVRRRPMLII GQIGTMTALLLIGILSIVLEGTPALPYVVLSLTILFLAFQQTAISTVTWLMLSEIFPM HVRGLGMGISTFCLWTANFLIGFTFPILLNHIGMSATFFIFVAMNILAILFVKKYVPE TKGRSLEQLEHSFRQYGRRADQEIQNQTTHLS*" /label="yfiG CDS" gene 824305..825753 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /label="yfiG gene" CDS 825780..826721 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_388708.1" /db_xref="EnsemblGenomes-Gn:BSU08270" /db_xref="EnsemblGenomes-Tr:CAB12656" /db_xref="InterPro:IPR011418" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11855" /db_xref="UniProtKB/Swiss-Prot:P54724" /translation="MKLSYVTDSLGHLPFEDMLNFAAKLGIDTLEMTTGGWSPAPHLN LDELLQSSEKRKEFSQALEKRNMTLCALNCSGNPLDPGELGKSHRDITDKTMELAGLL GVKKVIMMSGLPAGGPDDKVPNWITYTVSWPPVLKDILNYQWEDVAIPYWKKLVKKAE ACGVGKIALENFSSQLVYNPETLFRLRNAVGPMVGLNLDPSHLLWMGADPIIAARELG SAIHHVHGKDVRIERYLSAVNGLLETKEVTDPANRAWNYVAVGCGQDLQWWKEFFSVV KMMGYEGEVSLEMEDLTMSPEAGIRTSVEALKQTISQ*" /label="yfiH CDS" gene 825780..826721 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /label="yfiH gene" CDS 826731..827912 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26438878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388709.1" /db_xref="EnsemblGenomes-Gn:BSU08280" /db_xref="EnsemblGenomes-Tr:CAB12657" /db_xref="GOA:P94437" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12214" /db_xref="UniProtKB/Swiss-Prot:P94437" /translation="MMLNGERIISKPLRWAMVGGGRLSQVGYKHRIGALRDNTAFQLT AGAFDIDAERGKDFGVNLGVDAERCYPNYQTMFAEEAKRQDGIEVVSIATPNGTHYEI CKAALEAGVHVICEKPLFFTSAEGQEIKALAEKKGKIVGVTYGFSGNQMLLQMRAMIE QGMIGDIRVVDLQYTHGFCATDEGEKISAAQKWRVDPAIAGPSFVLGDLSTHTYYMSQ LIMPKMKIKELLCDRQSFVGSRAPLEDNAHVLMHYENGAVGTMWTSSINAGCMDGHRI RIVGSKASIEWWDSKPNELTYEVQGEPGQTLVRGMPYLDDVCNADERLGALHSEGLSE AWANIYLKFAIAIDAKNREDEEILNNLVYPDIDAGIEGIRWIENCVRSANQGSVWVEF K*" /label="yfiI CDS" gene 826731..827912 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /label="yfiI gene" downshifts 827902 /Source="Nicolas_upshifts" /id="D413" /incds=0 /nref=40 /ntot=113 /MaxReadThrough="0.88387" /MaxDrop="5.80704" /score="14.819468" /energy="-13" /TU="NA" /idTUdmin="U630" /TUdmin="-2003" /isTUend="FALSE" /label="downshifts" promotor_-35 827972..827978 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 827993..828012 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 828011 /Source="Nicolas_upshifts" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="upshifts" CDS 828036..829238 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /function="16.12: Sense" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LinK] (linearmycin resistance, biofilm formation)" /protein_id="NP_388710.1" /db_xref="EnsemblGenomes-Gn:BSU08290" /db_xref="EnsemblGenomes-Tr:CAB12658" /db_xref="GOA:P94438" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12215" /db_xref="UniProtKB/Swiss-Prot:P94438" /translation="MKALFFTRMFTLMVSCLMYLSIVKEDNWFGYVFIAAGAAMYAAN HVLLTKETNAIWFCLIDIAIGFSFGFIFPGTGLFIIMLCPVAVAFFLRGFPKRTAWSV LCLSSILFLTVLIRTYAMFGNEFVIDHLTSMTFVVFCGVVGKLIRKLLDAQDTAKQQF QELTESHLALSAAHQELHLYAKQVEELTAIYERNRMAREIHDTVGHKMTALLVQLQLL REWQKRDSQKADETVGVCETLAREALDDVRLSVRTLQTENDPSLIESLKQLTEDFCKN AGVTTEFAVSGDPAIIPLSLHPTLIRTVQEALTNAKRHGGAAACSIQLACTTDSISLV IKDDGKGNPEAALGFGLLNMKKRAAEHGGMIRFESERDQGFTVNAEFSLANKKWSFGP VQQKESLS*" /label="linJ CDS" gene 828036..829238 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /label="linJ gene" CDS 829235..829897 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LinJ] (linearmycin resistance, biofilm formation)" /protein_id="NP_388711.1" /db_xref="EnsemblGenomes-Gn:BSU08300" /db_xref="EnsemblGenomes-Tr:CAB12659" /db_xref="GOA:P94439" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12216" /db_xref="UniProtKB/Swiss-Prot:P94439" /translation="MIKIIITDDQDIVREGLASLLQLREELDVIATARNGQEAFEKAK ELEPDIVLMDIRMPVSNGVEGTKLITSSLPSVKVLMLTTFKDSALIAEALEEGASGYL LKDMSADTIVKAVMTVHSGGMVLPPELTAQMLNEWKREKQLKGINEIEKPNELLDLTE REIEVLAELGYGLNNKEIAEKLYITEGTVKNHVSNIISKLAVRDRTQAAIYSVRYGVS VF*" /label="linK CDS" gene 829235..829897 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /label="linK gene" downshifts 829905 /Source="Nicolas_upshifts" /id="D414" /incds=0 /nref=114 /ntot=229 /MaxReadThrough="-0.0105699999999995" /MaxDrop="4.23231" /score="20.4785449" /energy="-7.6" /TU="NA" /idTUdmin="U630" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 830041..830976 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) biofilm formation" /protein_id="NP_388712.2" /db_xref="EnsemblGenomes-Gn:BSU08310" /db_xref="EnsemblGenomes-Tr:CAB12660" /db_xref="GOA:P94440" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12217" /db_xref="UniProtKB/Swiss-Prot:P94440" /translation="MLQAENIKKAYGKKTIVKGISFSLKKGESFGLLGPNGAGKSTTI SMISGLVPHDSGNITVGGYVIGKETAKAKQKIGIVPQEIALYPTLTAHENLMFWGKMY GLTHGEAKKRAAEVLEYVGLTERAKDKIETFSGGMKRRINIGAALMHKPELLIMDEPT VGIDPQSRNHILETVKQLNETGMTVIYTSHYMEEVEFLCDRIGIIDQGEMIAIGTKTD LCSRLGGDTIIQLTVSGINEAFLVAIRSLAHVNDVTVHELELKIDISAAHHEKVVTSL LAEATAHHINLLSLQVQEPNLERLFLNLTGRTLRD*" /label="bifL CDS" gene 830041..830976 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /label="bifL gene" CDS 830989..832179 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388713.1" /db_xref="EnsemblGenomes-Gn:BSU08320" /db_xref="EnsemblGenomes-Tr:CAB12661" /db_xref="GOA:P94441" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12218" /db_xref="UniProtKB/Swiss-Prot:P94441" /translation="MKKSIWIAWKDVKIRITDRKGFMMLILMPLILTCILGAALGSVV DGGSRIDDIKVGYIQSDQSDTANMFTKDVLKKMKSIKVTKVGSKDKMKKLIDEKKIDV GIVIPNHWEAGKTSAVVNAAPDQTLKSSIIETAASSFIEQYKAVKEAASGSMDYISKT EAVKQGKLDPAQFAEKLAKTLEKETGDKLTIAEKSVGSKAVTSFQYYSAAMLCMFMLF HITVGAKSFLQEKDTETLARMLMTPAQKSVILFGKWLGTYLFAIIQFFIFLIVTINVF GVDWGGNLLLVSVLGLSYAAAVSGISMLLASCISDMKTADAIGGFGIQLLAVLGGSML PLYQFPDVLQSVSKAVPNRWALDGFLSLMEGGGWADLQKPVLLFAAIGFCSLVIGIRR LHTR*" /label="bifM CDS" gene 830989..832179 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /label="bifM gene" CDS 832193..833350 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388714.1" /db_xref="EnsemblGenomes-Gn:BSU08330" /db_xref="EnsemblGenomes-Tr:CAB12662" /db_xref="GOA:P94442" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12219" /db_xref="UniProtKB/Swiss-Prot:P94442" /translation="MKKILAICGIELSLIFKKPQNYLIMFAAPLLLTFVFGSMLSGND DKVRLAIVDQDDTILSQHYIRQLKAHDDMYVFENMSESKASEKLKQKKIAGIIVISRS FQTQLEKGKHPELIFRHGPELSEAPMVKQYAESALATLNIQVTAAKTASQTAGENWKA AYKTVFAKKHEDIVPAVTRQTLSDKKEGAEASDTASRAAGFSILFVMLTMMGAAGTIL EARKNGVWSRLLTASVSRAEIGAGYVLSFFVIGWIQFGILLLSTHWLFGINWGNPAAV IVLVSLFLLTVVGIGLMIAANVRTPEQQLAFGNLFVIATCMVSGMYWPIDIEPKFMQS IAEFLPQKWAMSGLTEIIANGARVTDILGICGILLAFAAITFAAGLKALRA*" /label="bifN CDS" gene 832193..833350 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /label="bifN gene" promotor_-35 832304..832309 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 832324..832342 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 832325 /Source="Nicolas_upshifts" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(833348..833422) /Source="Nicolas_S_feature" /locus_tag="new_909123_909197_c" /HighExp="LoTm, Sw, C90, HiOs, BC, MG 45, UNK1, Fru, S1, BI" /AntisenseName="yfiN" /AntisenseCor="-6.3486715356968801E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S284" downshifts complement(833391) /Source="Nicolas_upshifts" /id="D415" /incds=0 /nref=90 /ntot=257 /MaxReadThrough="1.41433" /MaxDrop="6.01369" /score="13.7314837" /energy="-11.5" /TU="U632" /idTUdmin="U632" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(833423..833971) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of phenolic acid decarboxylase" /protein_id="NP_388715.1" /db_xref="EnsemblGenomes-Gn:BSU08340" /db_xref="EnsemblGenomes-Tr:CAB12663" /db_xref="GOA:P94443" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR018309" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12220" /db_xref="UniProtKB/Swiss-Prot:P94443" /translation="MRVLKYAILGLLRKGELSGYDITSYFKEELGQFWSAKHSQIYPE LKKLTDEGFITFRTTIQGTKLEKKMYTLTDSGKQELHDWLIRHQPIPETVKDEFMLKA YFISCLSRQEASDLFKDQLQKRQAKLSDLQGSYEKLMASAEPMSFSSPDFGHYLVLTK ALEREKNYVSWLESILAMIDKD*" /label="padR CDS" gene complement(833423..833971) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /label="padR gene" S_feature complement(833972..834051) /Source="Nicolas_S_feature" /locus_tag="new_909747_909826_c" /HighExp="LoTm, Cold, G180, GM-0.2, Oxctl, T5.0H, GM 25, T3.30H, MG 60, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S285" promotor_-10 complement(834040..834059) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(834051) /Source="Nicolas_upshifts" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(834073..834078) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 834174..834177 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 834193..834212 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 834200 /Source="Nicolas_upshifts" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="upshifts" CDS 834244..834876 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11029590, 10913700, 21574267" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11029590, 10913700, 21574267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted esterase / acylglycerol lipase" /protein_id="NP_388716.1" /db_xref="EnsemblGenomes-Gn:BSU08350" /db_xref="EnsemblGenomes-Tr:CAB12664" /db_xref="GOA:Q79F14" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11951" /db_xref="UniProtKB/Swiss-Prot:Q79F14" /translation="MKKVLMAFIICLSLILSVLAAPPSGAKAESVHNPVVLVHGISGA SYNFFAIKNYLISQGWQSNKLYAIDFYDKTGNNLNNGPQLASYVDRVLKETGAKKVDI VAHSMGGANTLYYIKYLGGGNKIQNVVTLGGANGLVSSTALPGTDPNQKILYTSIYSL NDQIVINSLSRLQGARNIQLYGIGHIGLLSNSQVNGYIKEGLNGGGLNTN*" /label="estB CDS" gene 834244..834876 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /label="estB gene" downshifts 834855 /Source="Nicolas_upshifts" /id="D416" /incds=0 /nref=7 /ntot=100 /MaxReadThrough="0.87881" /MaxDrop="2.6151" /score="0.223019698" /energy="-8.5" /TU="NA" /idTUdmin="U633" /TUdmin=88 /isTUend="FALSE" /label="downshifts" promotor_-35 834991..834996 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 835010..835029 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 835020 /Source="Nicolas_upshifts" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="upshifts" CDS 835065..836153 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 24776724, 25935415, 27303652; Product type t : transporter" /codon_start=1 /transl_table=11 /product="acetyl-glucosamine metabolite exporter componentinvolved in biofilm formation" /protein_id="NP_388717.1" /db_xref="EnsemblGenomes-Gn:BSU08360" /db_xref="EnsemblGenomes-Tr:CAB12665" /db_xref="GOA:O31559" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG12893" /db_xref="UniProtKB/Swiss-Prot:O31559" /translation="MQIKEIFMIRCISCLSVVLLHIISMVLMLQAEALADISHTVDSF RTLLMFSTPAFIFISEFLLARSYPDGVPDGFLKKRGKVIFVPFLFIAAIDALLMTSAM GGEVTFLAFVQKYLANVFLGNFIGYFILVIFQFYMLHMMFHEYLKKASPKWVLSISFV VTAAYLGYFSAASPAPASEEGGAFPFFWVPFAGWLFYFCLAYYCGKEYKRFLALLNQY RWVVYGAAIASGALVVTVSYVGEIGMISSKRPDIMLYSTSMIFLCFHLFSKMKHVPKI MMFISNYSFSIYLLHAYFMIIGYVLLLNMPEIPAVPAVLLLFAVCTAGPIMTSWALNK FKYGYLFVGKIYQPKQKKVTVEVRDHAG*" /label="icaC CDS" gene 835065..836153 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /label="icaC gene" S_feature complement(835555..835943) /Source="Nicolas_S_feature" /locus_tag="new_911330_911718_c" /HighExp="S6, S8, S7, S5, LBGstat, H2O2, Mt0, Cold, G180, LPhT" /AntisenseName="yfiQ" /AntisenseCor="0.36913176163336098" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.976" /TUlongSig="NA" /TUlongPSig="NA" /label="S286" upshifts complement(835943) /Source="Nicolas_upshifts" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(835945..835964) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(835977..835985) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(836189..836806) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16862575" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16862575; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388718.1" /db_xref="EnsemblGenomes-Gn:BSU08370" /db_xref="EnsemblGenomes-Tr:CAB12666" /db_xref="GOA:O31560" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1RKT" /db_xref="SubtiList:BG12894" /db_xref="UniProtKB/Swiss-Prot:O31560" /translation="MSPKVTKEHKDKRQAEILEAAKTVFKRKGFELTTMKDVVEESGF SRGGVYLYFSSTEEMFRRIIETGLDEGLRKLDKSAEHQSVWASISSYLDELTEGLRDV ADTLAPVQFEYLVTAWRNEERRQYLEKRYDLFVERFSRLLQKGIDQGEFQPVQPLATI AKFFLNMNDGIIQNALYFDEEKADVSGLAESAKLYLKTVLQADEK*" /label="yfiR CDS" gene complement(836189..836806) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /label="yfiR gene" downshifts complement(836207) /Source="Nicolas_upshifts" /id="D417" /incds=0 /nref=29 /ntot=209 /MaxReadThrough="2.44114" /MaxDrop="4.07715" /score="22.1532141" /energy="-17.1" /TU="NA" /idTUdmin="U636" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(836772..838025) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811639, 15849754, 16850406, 16862575; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388719.1" /db_xref="EnsemblGenomes-Gn:BSU08380" /db_xref="EnsemblGenomes-Tr:CAB12667" /db_xref="GOA:O31561" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12895" /db_xref="UniProtKB/Swiss-Prot:O31561" /translation="MEKPLFRNQKGLMTLLASQTISSLGDWLHILAVLTLAAFQLHAS PLDMSLLMMSFALPVIVLGPVSGLLADRFDRKTIMFLSEIGRALTVISCVYVSELWQL YVLLSVQSCFSSLFLPAKNGKLKELAPEAHIQQAVSVSSIIDNSSKIFGPALGGTLIA AFSIHSVFYINAGAFFLSAVILFFLPRDAFLQKANTPQEKTAALTSIKEGLQFLKRMP LLLTGLLTACVVLFVLQIGDSQAIILIRSFSGAPPELAGWCMAVSGAGMLLTAAITGR RRITSYLLYFSAGTLLLGLATGGAPFLSGMGIAGITLFIFAFFIMGAAFGLVHIPFQI LVQTTVPVDYSGRVFGAIQSATTLASILGMAGGGVLAEWIGVSLAFLVCGCLLIMIGL ITLIGKKIAESRRYLVTKSNKGAQG*" /label="yfiS CDS" gene complement(836772..838025) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /label="yfiS gene" promotor_-10 complement(836833..836852) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(836845) /Source="Nicolas_upshifts" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(836866..836873) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(838059..838078) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(838077) /Source="Nicolas_upshifts" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(838093..838100) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 838104..838123 /Source="Nicolas_upshift_promotors" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 838109 /Source="Nicolas_upshifts" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="upshifts" CDS 838149..838685 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15581359, 22059487, 24821014, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15581359, 22059487, 24821014, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol S-transferase" /protein_id="NP_388720.1" /db_xref="EnsemblGenomes-Gn:BSU08390" /db_xref="EnsemblGenomes-Tr:CAB12668" /db_xref="GOA:O31562" /db_xref="InterPro:IPR023774" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="PDB:1RXQ" /db_xref="SubtiList:BG12896" /db_xref="UniProtKB/Swiss-Prot:O31562" /translation="MTSVNLSYPIGEYKPRESISKEQKDKWIQVLEEVPAKLKQAVEV MTDSQLDTPYRDGGWTVRQVVHHLADSHMNSYIRFKLSLTEETPAIRPYDEKAWSELK DSKTADPSGSLALLQELHGRWTALLRTLTDQQFKRGFYHPDTKEIITLENALGLYVWH SHHHIAHITELSRRMGWS*" /label="bstA CDS" gene 838149..838685 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /label="bstA gene" CDS complement(838682..840238) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388721.1" /db_xref="EnsemblGenomes-Gn:BSU08400" /db_xref="EnsemblGenomes-Tr:CAB12669" /db_xref="GOA:O31563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12897" /db_xref="UniProtKB/Swiss-Prot:O31563" /translation="MSEALTEQKSQKWAISLFTIGVFMAALDNGIISAALTTINESFS VSPSWGSWGITLYTLGLSVSVPIVGKLSDRYGRKKLFLIEVCLFGLGSLLVALSQSFP LFLISRLIQALGGGGIFIIGSSHILATLPKEKQGKALGLLGAMNGMAAVLGPNIGSFL LDWTGSWHWLFLINLPIAVLLVVFGACFIAETKAPEAKRLDAAGIFLLSLSILAVMYG MTNLDGANLLHSLGNPEVYGCIIFGILCFAALISYEKRVEMRGGDPILAYSLLRNHMF QRTLIIGLLSGGLLAAVIFIPSYVEQYLGVPAAKAGYWMTPLALASGIGAWLGGALTD KKGPVKTVILSGIISCAGFALFPLWVTEKWEFVIASVAAGIGFGFLLGAPLNVLVSEA AKTNKGTALGTLSLVRQIGLTLAPTLYAGFITAGFDQIGDEINSRLSDSGYSEKAMQM IPEIDSSEVSSLQEQIERIPVPEVKTAISDAIHASVASGYDHLYAAAAVVSLLVIAAI SIPAFRRQKR*" /label="yfiU CDS" gene complement(838682..840238) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /label="yfiU gene" promotor_-10 complement(840260..840278) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(840277) /Source="Nicolas_upshifts" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(840294..840297) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(840349..840831) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18990441; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388722.1" /db_xref="EnsemblGenomes-Gn:BSU08410" /db_xref="EnsemblGenomes-Tr:CAB12670" /db_xref="GOA:O31564" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12898" /db_xref="UniProtKB/Swiss-Prot:O31564" /translation="MEYNLHDTTVLNENILSSEEREIWVLYMKVLTSAGLGDVSEWMK LDMSMPQMKVLMLLNNHGTLKVSDIAEKMGASLSNTTGLLDRLEKSGFVKRSHSEEDR RSVVVQLTENAKKIFRGLYEKGHLKLKRSLELLSPEEKQAVYEGLSILSRALENAKKE *" /label="yfiV CDS" gene complement(840349..840831) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /label="yfiV gene" downshifts complement(840365) /Source="Nicolas_upshifts" /id="D418" /incds=0 /nref=58 /ntot=177 /MaxReadThrough="1.47849" /MaxDrop="4.15907" /score="27.2704527" /energy="-14.2" /TU="NA" /idTUdmin="U640" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(840856..840875) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(840872) /Source="Nicolas_upshifts" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(840890..840896) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 840917..840924 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 840938..840957 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 840946 /Source="Nicolas_upshifts" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="upshifts" CDS 841003..843573 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /EC_number="2.3.2.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol lysyltransferase involved in tRNA-dependent lysinylation of phospholipids" /protein_id="YP_003097695.1" /db_xref="EnsemblGenomes-Gn:BSU08425" /db_xref="EnsemblGenomes-Tr:CAX52582" /db_xref="GOA:C0H3X7" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022791" /db_xref="InterPro:IPR024320" /db_xref="UniProtKB/Swiss-Prot:C0H3X7" /translation="MLIKKNALSILKIVFPIAVLLFVIYQSKKELTNLSFKRTLMVIN GLERTDLFMLVLIGLLAVAAMSLYDYVLKYSLRLSITNGKVFRVSWIANSFNNVLGFG GLAGVGLRMMFYKEHTKDHKALVKGIAWLTSSMLLGLSVFSIFVAARVLPVDEVIHEK PWLWAVVIGFALILPLSLAVSKIKDRKAGDEENADKVKNPIFAYIGASVVEWLMAGTV IYFALFAMGIHADIRYVFGVFVIAAIGGMISLVPGGFGSFDLLFLLGMEQLGYHQEAI VTSIVLYRLAYSFIPFILGLFFAAGDLTENTMKRLETNPRIAPAIETTNVLLVVQRAV LVRILQGSLSLIVFVAGLIVLASVSLPIDRLTVIPHIPRPALLLFNGLSLSSALILLI LPIELYKRTKRSYTMAITALVGGFVFSFLKGLNISAIFVLPMIIVLLVLLKKQFVREQ ASYTLGQLIFAVALFTVALFNYNLIAGFIWDRMKKVLRHEYFVHSTSHITHATIMAII IVPLFFLIFTVVYHKRTKPIGEKADPERLAAFLNEKGGNALSHLGFLGDKRFYFSSDG NALLLFGKIARRLVVLGDPSGQRESFPLVLEEFLNEAHQKGFSVLFYQIEREDMALYH DFGYNFFKLGEEAYVDLNTFTLTGKKKAGLRAINNRFEREEYTFHVDHPPFSDAFLEE LKQISDEWLGSKKEKGFSLGFFDPSYLQKAPIAYMKNAEGEIVAFANVMPMYQEGEIS VDLMRYRGDAPNGIMDALFIRMFLWAKEEGCTSFNMGMAPLANVGTAFTSFWSERFAA VIFNNVRYMYSFSGLRAFKEKYKPEWRGKYLAYRKNRSLSVTMFLVTRLIGKSKKDSV *" /label="mprF CDS" gene 841003..843573 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /label="mprF gene" downshifts 843544 /Source="Nicolas_upshifts" /id="D419" /incds=0 /nref=121 /ntot=252 /MaxReadThrough="1.79352" /MaxDrop="5.78159" /score="49.2396824" /energy="-16.1" /TU="NA" /idTUdmin="U641" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(843591..844568) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 19254027, 24606332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter binding lipoprotein" /protein_id="NP_388725.1" /db_xref="EnsemblGenomes-Gn:BSU08440" /db_xref="EnsemblGenomes-Tr:CAB12673" /db_xref="GOA:O31567" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12901" /db_xref="UniProtKB/Swiss-Prot:O31567" /translation="MKKHISMLFVFLMAVMVLSACNSSESSSNSEVSSSKTRTVKHAM GTSDNIPANPKRIVVLTNEGTEALLALGIKPVGAVKSWKGDPWYDYLKDDMKGVKNVG LETEPNVEAIAELKPDLIIGNKVRQEKIYDQLNAIAPTVFAESLAGNWKDNLTLYANA VNKADKGKEVIADFDKRVSDLKNKLGDQTNKTVSVVRFLSGESRIYYTDSFPGIILDQ LGFKRPEKQVELFKKQKDQFTFSTDSKESIPDMDADVLFYFTYKADNAKENEKWANQW TSSSLWKNLKAVKSGNAHEVDDVVWTTAGGIKAANYLLDDIETYFLKTK*" /label="sxzY CDS" gene complement(843591..844568) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /label="sxzY gene" downshifts complement(843602) /Source="Nicolas_upshifts" /id="D420" /incds=0 /nref=165 /ntot=248 /MaxReadThrough="1.28876" /MaxDrop="7.70135" /score="35.2605181" /energy="-16.1" /TU="NA" /idTUdmin="U643" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 844583..844590 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(844595..844614) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 844605..844624 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 844607..844698 /Source="Nicolas_S_feature" /locus_tag="new_920382_920473" /HighExp="dia0, Lbexp, LBGexp, H2O2, G150, GM 10, Oxctl, dia15, Paraq, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S287" upshifts 844607 /Source="Nicolas_upshifts" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(844612) /Source="Nicolas_upshifts" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(844629..844636) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-35" CDS 844699..845700 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388726.1" /db_xref="EnsemblGenomes-Gn:BSU08450" /db_xref="EnsemblGenomes-Tr:CAB12674" /db_xref="GOA:O31568" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12902" /db_xref="UniProtKB/Swiss-Prot:O31568" /translation="MICKKASSKWIVLVCLIFILLTAVCASVVYGYTGTSWRQVYQAF TSFNGTNEHVIIKDVRLPRALVATVVGASLAAAGALMQALTKNPLASPGIFGINAGAG FFIVAGSFFLHIQSPQALVWSSFLGAAFTAAIVYAAGSLGREGLTPIKLTLAGAAMAA MFSSLTQGLLSVNELELAQVLFWLTGSVQGRSLDLLMTMFPYAAAALVICFFLGQKIN LLVMGEDVAKGLGQKTGLLKFVMALCVVMLAGSAVAIAGPISFIGIIIPHFARFVVGN DYRWVLPFSAVLGAILLVCADIGARYIIMPQEVPVGVMTAIIGMPVFVYIARRGAKL* " /label="sxzZ CDS" gene 844699..845700 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /label="sxzZ gene" CDS 845697..846728 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388727.1" /db_xref="EnsemblGenomes-Gn:BSU08460" /db_xref="EnsemblGenomes-Tr:CAB12675" /db_xref="GOA:O31569" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12876" /db_xref="UniProtKB/Swiss-Prot:O31569" /translation="MKLRFGVTAAEKKAWIVFLVLLGLTAAVLIISAGLGQRFIPPWD VAKTFFGAGSKLDELMIMSFRMPRILTALCAGVCLAAAGAILQGLVRNPLASPDIIGI TGGAAVAVVLLMMFFSDRSSSLTISLSWLPAAAFIGASAVGLIVYLLAYKNGASTFRL VLIGIGFSMSAQAMTTLLMIKGPIYRASQANVYITGSVYGSNWQHVKIAIILSVILLF ICFVALKNMNIQVLGEDIAAGAGSAVQRNRFFLLLLSTALTGCAVSVAGTIGFVGLMA PHIARRLVGSSYGALLPASALIGALLVLTADIVGRTLFAPVEVPAGVFTAAIGAPYFI YLLYKTRNS*" /label="sxzA CDS" gene 845697..846728 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /label="sxzA gene" downshifts 846709 /Source="Nicolas_upshifts" /id="D421" /incds=0 /nref=24 /ntot=154 /MaxReadThrough="3.26686" /MaxDrop="4.27732" /score="19.6751667" /energy="-12.8" /TU="NA" /idTUdmin="U642" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 846779..846781 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 846797..846816 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 846800 /Source="Nicolas_upshifts" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 846843..847724 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /EC_number="5.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative isomerase" /protein_id="NP_388728.1" /db_xref="EnsemblGenomes-Gn:BSU08470" /db_xref="EnsemblGenomes-Tr:CAB12676" /db_xref="GOA:O31570" /db_xref="InterPro:IPR003719" /db_xref="SubtiList:BG12877" /db_xref="UniProtKB/Swiss-Prot:O31570" /translation="MKEAEVLKYEAFTSSPGKGNPAGVVLQGDDYTEDEMQIIAERAG YSETSFIRKSESADLELRYFTPGHEMNLCGHATVASLYALCEKGMLESGKTYSIQTKA GILPVKISEKDGRIHITLEQASPQFKPFTGDRKKLADALGITDEDFHEDLPIVFGSTG IWTAIVPLKSLEASKKMVPDNKQFPEVLVDLPKASVHPFTFETVHPDSDLHGRHFSSP YSGTIEDPVTGTASGVMGAYMKHYGNAEQHKFIIEQGQEIGKDGKVEIEMNEAGGHVK VNMTGTAVYSETRILKI*" /label="yfhB CDS" gene 846843..847724 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /label="yfhB gene" promotor_-35 847735..847742 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 847758..847777 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 847767 /Source="Nicolas_upshifts" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 847812..848396 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 22287527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (nitroreductase family)" /protein_id="NP_388729.1" /db_xref="EnsemblGenomes-Gn:BSU08480" /db_xref="EnsemblGenomes-Tr:CAB12677" /db_xref="GOA:O31571" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR026021" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12878" /db_xref="UniProtKB/Swiss-Prot:O31571" /translation="MPQTEQIHQHSVLRDIIRSRRSIRKFKQEPVPSAVILDMLETAK YAPNHRVTEPWRFIYVSSETGKANLINTFAAFSKKSKPDMTEEKLQNFKNTLGRVPGF LLVVFQEDENERARDDDFAATSSLIQNLQLLAWEKGIGMVWKSGKILYDKEVHQAFGL QDNERFAAIIQTGYPDEAPEVKKRTPIRDRFTEM*" /label="yfhC CDS" gene 847812..848396 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /label="yfhC gene" downshifts 848383 /Source="Nicolas_upshifts" /id="D422" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="3.27483" /MaxDrop="6.40857" /score="21.7703837" /energy="-18.2" /TU="U645" /idTUdmin="U644" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(848435..848626) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388730.1" /db_xref="EnsemblGenomes-Gn:BSU08490" /db_xref="EnsemblGenomes-Tr:CAB12678" /db_xref="InterPro:IPR025435" /db_xref="SubtiList:BG12879" /db_xref="UniProtKB/Swiss-Prot:O31572" /translation="MGRNHIHKNRDKNKQKLPQVPDALKRETDGVYEEYSTELADADD REAQERAKAADNRAKKKSR*" /label="yfhD CDS" gene complement(848435..848626) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /label="yfhD gene" downshifts complement(848453) /Source="Nicolas_upshifts" /id="D423" /incds=0 /nref=65 /ntot=197 /MaxReadThrough="0.436919999999999" /MaxDrop="8.51174" /score="30.1998663" /energy="-18.2" /TU="NA" /idTUdmin="U649" /TUdmin=7 /isTUend="TRUE" /label="downshifts" upshifts complement(848658) /Source="Nicolas_upshifts" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(848661..848672) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(848687..848693) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(848693..848803) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388731.1" /db_xref="EnsemblGenomes-Gn:BSU08500" /db_xref="EnsemblGenomes-Tr:CAB12679" /db_xref="InterPro:IPR025437" /db_xref="SubtiList:BG12880" /db_xref="UniProtKB/Swiss-Prot:O31573" /translation="MEKKREKHQQGANLKKMQEVLYSGEFKKAEKAAKRK*" /label="yfhE CDS" gene complement(848693..848803) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /label="yfhE gene" promotor_-10 complement(848832..848843) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(848834) /Source="Nicolas_upshifts" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(848858..848864) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(848858..849769) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotide-or NAD-binding protein" /protein_id="NP_388732.1" /db_xref="EnsemblGenomes-Gn:BSU08510" /db_xref="EnsemblGenomes-Tr:CAB12680" /db_xref="GOA:O31574" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR010099" /db_xref="InterPro:IPR013549" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12881" /db_xref="UniProtKB/Swiss-Prot:O31574" /translation="MNIAMTGGTGFLGQHLTGVLTRQGHHVYILSRNARETEQKNMTY VQWLSEGAAPEQELPHIDVWINLAGKSIFGRWTEKTKQHILSSRINATREVQRLIQKQ KEKPKTLIQASAVGIYGTSLEKTFTEDSATSDEDFLSHTAHLWEKEGQHIEAMGIRTV YARFGVMLGEKGALPLMILPYKFLAGGTIGTGRQWLSWIHVEDAAQMIRYAVENAGIS GPMNVTAPNPVDMKQFGKTIARVKHRPHWLPVPEFFLSKALGEMSLLIVKGQRALPKK AITSGFRFTYSDLEFALSQLIADRKTV*" /label="yfhF CDS" gene complement(848858..849769) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /label="yfhF gene" promotor_-35 849655..849658 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 849675..849694 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 849685..849857 /Source="Nicolas_S_feature" /locus_tag="new_925460_925632" /HighExp="LBGstat, Lbtran, T1.30H, T2.0H, T2.30H, M9-stat, T1.0H, T3.0H, Sw, G180" /AntisenseName="yfhF" /AntisenseCor="-5.3501479327985699E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S288" upshifts 849685 /Source="Nicolas_upshifts" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(849791..849809) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(849805) /Source="Nicolas_upshifts" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(849823..849829) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 849858..850652 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /function="16.3: Control" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8946165, 10869079, 12547390, 23284295, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8946165, 10869079, 12547390, 23284295, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulatory protein RecX" /protein_id="NP_388733.1" /db_xref="EnsemblGenomes-Gn:BSU08520" /db_xref="EnsemblGenomes-Tr:CAB12681" /db_xref="GOA:O31575" /db_xref="InterPro:IPR003783" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12882" /db_xref="UniProtKB/Swiss-Prot:O31575" /translation="MPFITKISTQKKNTERFNIFLDDKYAFSVDADVLVKFELKKGKE LDDLDIIEIQYGDEVKKGFNRALDFLSYRMRSTKEVEDHLKKKETSPPVIAEVIHRLN DYKYLNDQEFAAAYVSTHKKTNGKGPDVLFRELRAKGIDDDTIKEALSSFSFEDQTRE AVKHVEKLLKKDKKLSTKELKQRAQLQLQRKGFSFDVISAAMDQIEYENDEDTEKEAL RLHAEKAFRKYRYDGSYESAMKVKQFLFRKGFSLDLIEQLLQEEEY*" /label="recX CDS" gene 849858..850652 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /label="recX gene" CDS 850654..850968 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388734.1" /db_xref="EnsemblGenomes-Gn:BSU08530" /db_xref="EnsemblGenomes-Tr:CAB12682" /db_xref="InterPro:IPR014938" /db_xref="InterPro:IPR036289" /db_xref="PDB:1SF9" /db_xref="SubtiList:BG12883" /db_xref="UniProtKB/Swiss-Prot:O31576" /translation="MEKRYSQMTPHELNTEIALLSEKARKAEQHGIINELAVLERKIT MAKAYLLNPEDYSPGETYRVENTEDEFTISYLNGVFAWGYRTSSPQQEEALPISVLQE KE*" /label="yfhH CDS" gene 850654..850968 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /label="yfhH gene" S_feature complement(850876..851144) /Source="Nicolas_S_feature" /locus_tag="new_926651_926919_c" /HighExp="S8, S6, S5, S7, C30, S4, nit, ferm, BT, G135" /AntisenseName="yfhH" /AntisenseCor="-0.53569713251514905" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S289" downshifts 850958 /Source="Nicolas_upshifts" /id="D424" /incds=0 /nref=71 /ntot=206 /MaxReadThrough="2.93348" /MaxDrop="5.2859" /score="24.7235138" /energy="-11.6" /TU="NA" /idTUdmin="U648" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 851042..851047 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 851063..851082 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 851068 /Source="Nicolas_upshifts" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" CDS 851111..852304 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388735.1" /db_xref="EnsemblGenomes-Gn:BSU08540" /db_xref="EnsemblGenomes-Tr:CAB12683" /db_xref="GOA:O31577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12884" /db_xref="UniProtKB/Swiss-Prot:O31577" /translation="MSIKNPSVKFIIFVLMICTFSIGYTEYAVMGILTSIANDFHIQV SSAGLLVTAYAASVCLTGPLVTIISVKLPRKPVLLGLMAIFILSNLMSALAPNFAVLA ISRILSASIHGAFFAIAMVFASEMVPPEKRAAAAASMNGGLTVALMLGVPFGSYLGDV LNWRAVFSIITALGVIGFLGLMAAVPNRKPKVIPMLMNEWGVFKHKQVLFSFAITILG YSGVFIAYTFIEPILRHSAGFSTVGITGALFAYGLGGVAGNFFAGKVPLPLLTRTMIG VMIGLIGVLAVFPYIAIYPAAAIVATFLFGACAFGTPPLLQTKVISSSEGGTTIAAAV SVSAFNLANALGAWIGGMILNGTGSYSWLFAGGALMTACGLVLSTFAHLSEKKSVYEY QVNKG*" /label="yfhI CDS" gene 851111..852304 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /label="yfhI gene" S_feature 852305..852539 /Source="Nicolas_S_feature" /locus_tag="new_928080_928314" /HighExp="G180, Paraq, C30, Oxctl, H2O2, G135, G150, S8, Heat, LBGstat" /AntisenseName="sspK" /AntisenseCor="1.9886505145521101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S290" CDS complement(852337..852489) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054573.1" /db_xref="EnsemblGenomes-Gn:BSU08550" /db_xref="EnsemblGenomes-Tr:CAE01449" /db_xref="GOA:Q7WY75" /db_xref="InterPro:IPR012611" /db_xref="SubtiList:BG14175" /db_xref="UniProtKB/Swiss-Prot:Q7WY75" /translation="MVRNKEKGFPYENENKFQGEPRAKDDYASKRADGSINQHPQERM RASGKR*" /label="sspK CDS" gene complement(852337..852489) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /label="sspK gene" downshifts complement(852354) /Source="Nicolas_upshifts" /id="D425" /incds=0 /nref=24 /ntot=45 /MaxReadThrough="2.36419" /MaxDrop="4.9889" /score="20.2715496" /energy="-12.3" /TU="NA" /idTUdmin="U652" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 852518..852525 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 852539..852558 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 852541..852613 /Source="Nicolas_S_feature" /locus_tag="new_928316_928388" /HighExp="dia5, LPhT, Diami, dia15, Etha, T0.30H, H2O2, LBGstat, BC, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S291" upshifts 852541 /Source="Nicolas_upshifts" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(852548..852559) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(852558) /Source="Nicolas_upshifts" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(852574..852580) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 852614..852883 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388736.1" /db_xref="EnsemblGenomes-Gn:BSU08560" /db_xref="EnsemblGenomes-Tr:CAB12684" /db_xref="InterPro:IPR026952" /db_xref="SubtiList:BG12885" /db_xref="UniProtKB/Swiss-Prot:O31578" /translation="MNMYIEKLTNLLLEKNEMISYIQAKTWVELLWSDFEATYAKAGH AYQGEKMTEKIVTQWIENYGGQLHLFQSSRNDVNDYLNQSRGLLH*" /label="yfhJ CDS" gene 852614..852883 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /label="yfhJ gene" downshifts 852872 /Source="Nicolas_upshifts" /id="D426" /incds=0 /nref=62 /ntot=233 /MaxReadThrough="2.9538" /MaxDrop="5.3621" /score="19.3423239" /energy="-10.6" /TU="NA" /idTUdmin="U650" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 852961..852967 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 852982 /Source="Nicolas_upshifts" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 852983..853001 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 853028..853546 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388737.1" /db_xref="EnsemblGenomes-Gn:BSU08570" /db_xref="EnsemblGenomes-Tr:CAB12685" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12886" /db_xref="UniProtKB/Swiss-Prot:O31579" /translation="MKKKQVMLALTAAAGLGLTALHSAPAAKAAPLHDISVSMPSSDT YIIKAGKLNVRTEPNHEGDILGTVSSEQKVKVDRFVNADWAQIHFKGKKAYISTHFLM KTASQAKTTKQTAFYTPTPENGKAKQLSSGTEVTILGWGFSENGGFDFTWAFVDYGGV KGYIHTKDLQMR*" /label="yfhK CDS" gene 853028..853546 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /label="yfhK gene" S_feature 853547..853614 /Source="Nicolas_S_feature" /locus_tag="new_929322_929389" /HighExp="Etha, Sw, Salt, M9-stat, B60, B36, Gly, LoTm, BC, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S292" promotor_-35 853582..853591 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-35" promotor_-10 853603..853618 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-10" upshifts 853616 /Source="Nicolas_upshifts" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="upshifts" CDS 853631..853963 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor for peptide SdpC immunity" /protein_id="NP_388738.1" /db_xref="EnsemblGenomes-Gn:BSU08580" /db_xref="EnsemblGenomes-Tr:CAB12686" /db_xref="GOA:O31580" /db_xref="InterPro:IPR025962" /db_xref="SubtiList:BG12887" /db_xref="UniProtKB/Swiss-Prot:O31580" /translation="MTGLVGGGLMIIAGILIKLFPPKSINSVYGYRTRRSMSDQRLWN EANRYSASLMILSGLVIAGMGLLLGSNLFILQLILLIAACVITFMLTEKRLKIMTHSQ GGDRSGRS*" /label="spdL CDS" gene 853631..853963 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /label="spdL gene" CDS 853950..854810 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /EC_number="3.3.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16597997, 20941576" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16597997, 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stress induced epoxide hydrolase" /protein_id="NP_388739.1" /db_xref="EnsemblGenomes-Gn:BSU08590" /db_xref="EnsemblGenomes-Tr:CAB12687" /db_xref="GOA:O31581" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12888" /db_xref="UniProtKB/Swiss-Prot:O31581" /translation="MDGVKCQFVNTNGITLHVAAAGREDGPLIVLLHGFPEFWYGWKN QIKPLVDAGYRVIAPDQRGYNLSDKPEGIDSYRIDTLRDDIIGLITQFTDEKAIVIGH DWGGAVAWHLASTRPEYLEKLIAINIPHPHVMKTVTPLYPPQWLKSSYIAYFQLPDIP EASLRENDYDTLDKAIGLSDRPALFTSEDVSRYKEAWKQPGALTAMLNWYRALRKGSL AEKPSYETVPYRMIWGMEDRFLSRKLAKETERHCPNGHLIFVDEASHWINHEKPAIVN QLILEYLKNQ*" /label="ephM CDS" gene 853950..854810 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /label="ephM gene" downshifts 854808 /Source="Nicolas_upshifts" /id="D427" /incds=0 /nref=27 /ntot=191 /MaxReadThrough="5.0793" /MaxDrop="4.1326" /score="3.7712168" /energy="-8.4" /TU="U653,U654" /idTUdmin="U654" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 854868..854874 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 854888..854899 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 854896..854960 /Source="Nicolas_S_feature" /locus_tag="new_930671_930735" /HighExp="Etha, S5, M9-stat, T0.30H, Sw, T-0.40H, B60, S8, B36, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S293" upshifts 854896 /Source="Nicolas_upshifts" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(854918..854937) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(854927) /Source="Nicolas_upshifts" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 854943..854949 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(854951..854952) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 854962..855042 /Source="Nicolas_S_feature" /locus_tag="new_930737_930817" /HighExp="M9-stat, LBGexp, Lbexp, T0.30H, dia0, T1.30H, T1.0H, LBGtran, Paraq, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF, SigB" /TUshortPSig="1, 0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S294" upshifts 854962 /Source="Nicolas_upshifts" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 854964..854982 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 855043..856032 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /EC_number="2.4.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8921856, 9636707, 23632331; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bactoprenol glycosyl transferase, phageorigin" /protein_id="NP_388740.1" /db_xref="EnsemblGenomes-Gn:BSU08600" /db_xref="EnsemblGenomes-Tr:CAB12688" /db_xref="GOA:Q45539" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11834" /db_xref="UniProtKB/Swiss-Prot:Q45539" /translation="MKQGLISIIIPSYNEGYNVKLIHESLKKEFKNIHYDYEIFFIND GSVDDTLQQIKDLAATCSRVKYISFSRNFGKEAAILAGFEHVQGEAVIVMDADLQHPT YLLKEFIKGYEEGYDQVIAQRNRKGDSFVRSLLSSMYYKFINKAVEVDLRDGVGDFRL LSRQAVNALLKLSEGNRFSKGLFCWIGFDQKIVFYENVERKNGTSKWSFSSLFNYGMD GVVSFNHKPLRLCFYTGIFILLLSIIYIIATFVKILTNGISVPGYFTIISAVLFLGGV QLLSLGIIGEYIGRIYYETKKRPHYLIKEANIPNKDLPETNELKSMRRLTKMH*" /label="csbB CDS" gene 855043..856032 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /label="csbB gene" upshifts complement(855192) /Source="Nicolas_upshifts" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(855197..855201) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(855218..855222) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 856033..856103 /Source="Nicolas_S_feature" /locus_tag="new_931808_931878" /HighExp="LPhT, Heat, Etha, LBGexp, M9-stat, LBGtran, Lbexp, Sw, dia0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigB" /TUshortPSig="1, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S295" CDS 856104..858689 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23632331; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388741.2" /db_xref="EnsemblGenomes-Gn:BSU08610" /db_xref="EnsemblGenomes-Tr:CAB12689" /db_xref="GOA:O31582" /db_xref="InterPro:IPR018580" /db_xref="SubtiList:BG12889" /db_xref="UniProtKB/Swiss-Prot:O31582" /translation="MKRKHIMIYAASLLVSVLAHAFFVKEWAEGRYMTGPGDGLAQMI VFKKLLFDQYTHGNFFYNYSFGLGGGTFSQLGYYFSASFLFLAVSAAVWLLQAVQLIG ETDTLFWAESAVFISIFKLSLIIFTSASVFHYLLKHRAASFTGAVLYGVSIIYFRHEA YWEFFTDTMVWLPLLVLGAEKIIRERRPAWFIVACSLTLINNFYFAYINLIFIGIYVL FRWLIRLEPHEEKRWIQIRLFLVSGFISFGISAAAFVPVVYGFLNNLRPPYSQKIEWL NFDDNILFSSRIIIVPAAFLLFLFIISFYKNRVFRLFAGLSLLFILFHFSPYAASVFN GFSAPQNRFEYVLAFTIAGAAAAGLSQLSELKRKELLPAAAVVLLLYLYHIQRYKLDI WKPANESILLLLLMTIAALFAAAFAKKRAKMAVYGIIILSSLFVANSYQKYALSEGGD LDSVTKEYLTSEEYRGRESSELIRRLQKEDDDPLMRIDWMNGVRNNTPIIYGFNGFSA YSSILNKDLLAFYWNDLSIDMGRESVSRYASLGDRANLYSLLYGKYYMTEKTNEASVP YGFKKHLETEHYAVYENQYMLPFVKTADAIYSESELDRLPALAKEQAMLKGIILKDPS GKTEQTPKPSNLITKSDITAKQAQYQNGLLTVTGENGGELIITPKQPSSAPGDYYVSF YLKSKAKDKGFTLKVNDYVTTRKSNKSIYKTGVNNITVRVPKSGHISINLPKGTYELR NIALYEENYQTLKNAVMQNKTEKADKLNWNKNRLTFSYHLSKDQYIMLPIPYEKGWEL KINGKTQKIEKADYAFIGFKAQKGDNHIELTYYPPYFKISAIISLVSLLLAVFYIRRK KPGSI*" /label="yfhO CDS" gene 856104..858689 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /label="yfhO gene" downshifts 858658 /Source="Nicolas_upshifts" /id="D428" /incds=0 /nref=63 /ntot=217 /MaxReadThrough="2.13267" /MaxDrop="4.17784" /score="2.41489488" /energy="-13.3" /TU="NA" /idTUdmin="U657" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(858682..859665) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10463184, 10524235, 15849754, 16850406, 24237659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_388742.1" /db_xref="EnsemblGenomes-Gn:BSU08620" /db_xref="EnsemblGenomes-Tr:CAB12690" /db_xref="GOA:O31583" /db_xref="InterPro:IPR007404" /db_xref="SubtiList:BG12890" /db_xref="UniProtKB/Swiss-Prot:O31583" /translation="MDTGTHVVMGIALGGIATLDPVVGSDPAMAHAVMIATLAGSQAP DIDTVLKLKNNAVYIRNHRGFTHSIPAVLFWSVIIPAILYLFYPQADFLHLWLWTLLA VVLHVFVDIFNAYGTQAIRPFSKKWVALGLINTFDPFIFISHLAAIAIWYAGGSPGIT FLSLYIILVGYYLVRLIMQLRIKRKLHEMIHDEIESIIISPTMKFRQWRIAVTTAHAF YVGRSMEGHVVILDTFNRVPVPETDVMHAAKQDDNIAAFLSFSPVYRWEVDTFKDHYE VRFIDLRYRSKGHYPFVAIVHIGHDLTIRSSYTGWIFSEEKLQKKLKLGSI*" /label="yfhP CDS" gene complement(858682..859665) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /label="yfhP gene" downshifts complement(858716) /Source="Nicolas_upshifts" /id="D429" /incds=0 /nref=28 /ntot=200 /MaxReadThrough="2.65266" /MaxDrop="4.43244" /score="25.5564412" /energy="-17.5" /TU="NA" /idTUdmin="U661" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 859139..859148 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 859161..859180 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 859165 /Source="Nicolas_upshifts" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(859666..859813) /Source="Nicolas_S_feature" /locus_tag="new_935441_935588_c" /HighExp="Diami, dia15, M9-stat, dia5, Etha, H2O2, S6, Salt, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S296" promotor_-35 859770..859774 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 859790..859809 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 859797 /Source="Nicolas_upshifts" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 859803..859880 /Source="Nicolas_S_feature" /locus_tag="new_935578_935655" /HighExp="H2O2, G150, G180, LBGstat, dia15, Diami, Oxctl, Paraq, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S297" promotor_-10 complement(859811..859830) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(859813) /Source="Nicolas_upshifts" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(859845..859852) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 859881..860990 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /EC_number="3.2.2.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10463184, 20971907, 21954439, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10463184, 20971907, 21954439, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="A/G-specific adenine glycosylase or DNA-(apurinic or apyrimidinic site) lyase" /protein_id="NP_388743.1" /db_xref="EnsemblGenomes-Gn:BSU08630" /db_xref="EnsemblGenomes-Tr:CAB12691" /db_xref="GOA:O31584" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR005760" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR029119" /db_xref="SubtiList:BG12891" /db_xref="UniProtKB/Swiss-Prot:O31584" /translation="MNVLEDKLKQKDIQQFRDDLISWFEREQRVLPWREDQDPYKVWV SEVMLQQTRVETVIPYFLRFVEQFPTVEALADADEEKVLKAWEGLGYYSRVRNLQSAV KEVKQEYGGIVPPDEKDFGGLKGVGPYTKGAVLSIAYNKPIPAVDGNVMRVMSRILSI WDDIAKPKTRTIFEDAIRAFISKEKPSEFNQGLMELGALICTPKSPSCLLCPVQQHCS AFEEGTERELPVKSKKKKPGIKTMAAIVLTDEDGQVYIHKRPSKGLLANLWEFPNLET QKGIKTEREQLIAFLENEYGIQADISDLQGVVEHVFTHLVWNISVFFGKVKQVSDTSK LKKVTKEELEQFAFPVSHQKIWKMAGEAAAISAAP*" /label="mutY CDS" gene 859881..860990 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /label="mutY gene" promotor_-35 860827..860831 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 860847..860866 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 860859 /Source="Nicolas_upshifts" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 860991..861303 /Source="Nicolas_S_feature" /locus_tag="new_936766_937078" /HighExp="H2O2, G150, dia15, G135, G180, Oxctl, Paraq, dia0, LBGexp, Lbexp" /AntisenseName="yfhS" /AntisenseCor="-0.72611377663365595" /AntisenseRegPval="-44.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S298" CDS complement(860998..861222) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10463184" /codon_start=1 /transl_table=11 /product="conserved protein related to sporulation" /protein_id="NP_388744.1" /db_xref="EnsemblGenomes-Gn:BSU08640" /db_xref="EnsemblGenomes-Tr:CAB12692" /db_xref="SubtiList:BG12892" /db_xref="UniProtKB/Swiss-Prot:O31585" /translation="MYVGRDMSELNMVSKKDWKNSELAYFHHAFQQIMPYLNEEGQSK YRELTQEIEARGGMKRNEADYSHGTRVSYD*" /label="yfhS CDS" gene complement(860998..861222) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /label="yfhS gene" promotor_-10 complement(861252..861263) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(861254) /Source="Nicolas_upshifts" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(861277..861283) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 861304..862056 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /EC_number="1.3.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 12440970, 17329825, 21185310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 12440970, 17329825, 21185310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase III" /protein_id="NP_388745.1" /db_xref="EnsemblGenomes-Gn:BSU08650" /db_xref="EnsemblGenomes-Tr:CAB12693" /db_xref="GOA:P71079" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIC" /db_xref="PDB:3OID" /db_xref="SubtiList:BG12221" /db_xref="UniProtKB/Swiss-Prot:P71079" /translation="MEQNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALE TAEEIEKLGVKVLVVKANVGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELE ETHWDWTMNINAKALLFCAQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAA LEALTRYLAVELSPKQIIVNAVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIK DMVDTVEFLVSSKADMIRGQTIIVDGGRSLLV*" /label="fabL CDS" gene 861304..862056 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /label="fabL gene" promotor_-35 862073..862079 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 862094..862105 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 862095 /Source="Nicolas_upshifts" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(862102..862116) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(862123) /Source="Nicolas_upshifts" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(862125..862129) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 862125..862379 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1744043, 7592342, 9540829, 19542328, 23314362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744043, 7592342, 9540829, 19542328, 23314362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (gamma-type SASP)" /protein_id="NP_388746.1" /db_xref="EnsemblGenomes-Gn:BSU08660" /db_xref="EnsemblGenomes-Tr:CAB12694" /db_xref="GOA:P07784" /db_xref="InterPro:IPR006341" /db_xref="SubtiList:BG10789" /db_xref="UniProtKB/Swiss-Prot:P07784" /translation="MANSNNFSKTNAQQVRKQNQQSAAGQGQFGTEFASETNAQQVRK QNQQSAGQQGQFGTEFASETDAQQVRQQNQSAEQNKQQNS*" /label="sspE CDS" gene 862125..862379 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /label="sspE gene" downshifts 862377 /Source="Nicolas_upshifts" /id="D430" /incds=0 /nref=261 /ntot=269 /MaxReadThrough="1.59207" /MaxDrop="8.74804" /score="9.25353719" /energy="-9.5" /TU="NA" /idTUdmin="U660" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(862402) /Source="Nicolas_upshifts" /id="D431" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.21036" /MaxDrop="5.14076" /score="-9.78320441" /energy="-7.1" /TU="NA" /idTUdmin="U663" /TUdmin="-1687" /isTUend="FALSE" /label="downshifts" CDS 862468..862812 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388747.1" /db_xref="EnsemblGenomes-Gn:BSU08670" /db_xref="EnsemblGenomes-Tr:CAB12695" /db_xref="InterPro:IPR025572" /db_xref="SubtiList:BG12222" /db_xref="UniProtKB/Swiss-Prot:P71080" /translation="MSQRVCFMEIEMIKGGNVYTFIRLKEEPMTEFEKLVSEQMKTMD KLLDLQSELDRCKQIEAELRHLERDARLRGIQAEIAVKRKHLADIQDMFQKQTEQVIR SYRSSEKPSSFV*" /label="ygaB CDS" gene 862468..862812 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /label="ygaB gene" promotor_-35 862475..862483 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 862494..862512 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 862496 /Source="Nicolas_upshifts" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="upshifts" downshifts 862795 /Source="Nicolas_upshifts" /id="D432" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.84572" /MaxDrop="3.29993" /score="13.9694142" /energy="-11.5" /TU="U666" /idTUdmin="U660" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 862851..862858 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 862872..862891 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 862881..862955 /Source="Nicolas_S_feature" /locus_tag="new_938656_938730" /HighExp="Etha, dia15, dia5, Diami, Salt, H2O2, BC, T5.0H, Cold, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S299" upshifts 862881 /Source="Nicolas_upshifts" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="upshifts" CDS 862956..863486 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19383706, 22333191; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding factor" /protein_id="NP_388748.3" /db_xref="EnsemblGenomes-Gn:BSU08680" /db_xref="EnsemblGenomes-Tr:CAB12696" /db_xref="InterPro:IPR007295" /db_xref="InterPro:IPR016882" /db_xref="InterPro:IPR035930" /db_xref="SubtiList:BG12223" /db_xref="UniProtKB/Swiss-Prot:Q796Z1" /translation="MGYPKEGETIQIHSYKHNGLIHRIWNETTILKSTEMCVIGANDR TMVTESDGRTWITREPAICYFHARQWFNVIGMLREDGVHYYCNISSPFAYDGEAIKYI DYDLDVKVFPDMTYNILDEDEYDDHRKAMNYPKEIDSILRDYLNTLLHWIHQRQGPFA PEFVDMWYERYLRYTK*" /label="ygaC CDS" gene 862956..863486 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /label="ygaC gene" downshifts 863477 /Source="Nicolas_upshifts" /id="D433" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="6.10669" /MaxDrop="3.97335" /score="-5.22328881" /energy="-7" /TU="U667" /idTUdmin="U666" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 863574..865316 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388749.2" /db_xref="EnsemblGenomes-Gn:BSU08690" /db_xref="EnsemblGenomes-Tr:CAB12697" /db_xref="GOA:P71082" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12224" /db_xref="UniProtKB/Swiss-Prot:P71082" /translation="MGVMKRYMQFVKPYKKQIFVTVLIGIVKFSIPLALPLLLKYVVD DIIQGGGTASDKTTSLFTIMAIMFALFLILRPPVEYYRQYFAQWTASKVLYDIRAKLF DHIQKLSLRFYANTRTGEVISRVINDVEQTKDFVITGLMNIWLDMLTILIVISIMLTL DVKLTLISIVLFPLYGISVKYFYGRLRKLTRERSQALAQVQGHLHERIQGMPVIRSFA IEDHEQAQFNEKNGHFLDKAIRHTNWNAKTFAVVNTITDLAPLIVIACAGYFVINGPL TVGTMVAFVGYIDRMYNPVRRLINSSTTLTQSIASMDRVFEFIDEPYELTDKPNAIKA DQIRGGVEFQNVSFQYEKDKENILHDVSLKVNRGETVALVGMSGGGKSTLVSLIPRFY DVTSGRLLIDGTDIRDYEARSLRNQVGMVLQDTFLFSETIRENIAIGKPDATLEEIIE AAKAANAHEFIMSFPEGYETRVGERGVKLSGGQKQRISIARVFLKNPPLLILDEATSA LDLESEHYIQEAMDKLAKDRTTFVVAHRLSTITHADKIVVMENGTIIEIGTHDELMDY ESQYKHLFTIQNLN*" /label="ygaD CDS" gene 863574..865316 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /label="ygaD gene" downshifts 865303 /Source="Nicolas_upshifts" /id="D434" /incds=0 /nref=87 /ntot=233 /MaxReadThrough="2.54676" /MaxDrop="5.20475" /score="22.3853226" /energy="-14.1" /TU="NA" /idTUdmin="U667" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(865393..866454) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388750.1" /db_xref="EnsemblGenomes-Gn:BSU08700" /db_xref="EnsemblGenomes-Tr:CAB12698" /db_xref="GOA:P71083" /db_xref="InterPro:IPR010343" /db_xref="SubtiList:BG12225" /db_xref="UniProtKB/Swiss-Prot:P71083" /translation="MKLGARIFKTGIAITLALYLASWIGLPAPIFAGIAAIFAIQPSI YRSFLIIIDQVQANIIGAVIATVFGLIFGPSPIMIGLTAVIVITIMLKLKIEHTISIA LVTVIAILESAGDDFLMFALIRTSTVILGVLSSFIVNLVFLPPKYETKLIHNTVENTE EIMKWIRLSMRQSTEHSILKEDIEKLKEKMIKLDQTYLLYKEERSYFKKTTYVKSRKL VLFRQAIITANRALDTLKKLHRLENEIYHMPEEFQETLTEELDYLLYWHERILMRFVG KIKPHDDAVEEGIRYKQLLTKSFLKNQQNTDEELIDYNMLNIMASAVEYREQLEHLET LITSFQTYHPKDCEIETEE*" /label="ygaE CDS" gene complement(865393..866454) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /label="ygaE gene" downshifts complement(865404) /Source="Nicolas_upshifts" /id="D435" /incds=0 /nref=181 /ntot=254 /MaxReadThrough="1.1413" /MaxDrop="7.13599" /score="26.0617552" /energy="-9.4" /TU="NA" /idTUdmin="U668" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature complement(866455..866545) /Source="Nicolas_S_feature" /locus_tag="new_942230_942320_c" /HighExp="G180, Oxctl, Paraq, C30, G150, LBGexp, LPhT, S4, G135, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S300" promotor_-10 complement(866543..866562) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(866552) /Source="Nicolas_upshifts" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(866577..866584) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(866674..867963) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231799, 19930658; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde aminotransferase, classIII aminotransferase" /protein_id="NP_388751.3" /db_xref="EnsemblGenomes-Gn:BSU08710" /db_xref="EnsemblGenomes-Tr:CAB12699" /db_xref="GOA:P71084" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11943" /db_xref="UniProtKB/Swiss-Prot:P71084" /translation="MHTKSIELHNEALQHIVGGVNSPSRSYKAVGGGSPVAMEKASGA YFWDVDGNKYIDYLAAYGPIITGHAHPHITEAIKKAAENGVLYGTPTKHEVTFAKMLK EAIPAMDKVRFVNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPS TLGTPDSAGVPKSIANEVITVPFNDIDSYKAALEKWGSEIAAVLVEPIVGNFGIVEPK EGFLEQVNELTHNAGALVIYDEVITAFRFMYGGAQDLLQVKPDLTALGKIIGGGLPIG AYGGKQEIMEQVAPLGPAYQAGTMAGNPASILSGIACLEVLKEKGVYEKLDHLGAMLE EGILKHAETHGITITVNRLKGALTVYFSDEKVENYEQAERSDGETFSTFFKLMLERGI NLAPSKYEAWFITTAHTEQDIKDTLTAVEDAFKHLKN*" /label="gsaB CDS" gene complement(866674..867963) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /label="gsaB gene" downshifts complement(866677) /Source="Nicolas_upshifts" /id="D436" /incds=0 /nref=235 /ntot=258 /MaxReadThrough="2.54961" /MaxDrop="5.8522" /score="29.5551149" /energy="-11" /TU="NA" /idTUdmin="U669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(867991..868010) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(868010) /Source="Nicolas_upshifts" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(868012..868723) /Source="Nicolas_S_feature" /locus_tag="new_943787_944498_c" /HighExp="LoTm, M9-stat, B60, S8, C30, Cold, B36, T1.30H, Etha, T2.0H" /AntisenseName="ygaF" /AntisenseCor="-0.29702219161000198" /AntisenseRegPval="-6.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S301" promotor_-35 complement(868022..868027) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 868056..868063 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 868077..868096 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 868077 /Source="Nicolas_upshifts" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="upshifts" CDS 868116..868589 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /EC_number="1.11.1.15" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10644761, 11349039, 12950915, 21910476, 26723255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin with versatile activity" /protein_id="YP_054574.1" /db_xref="EnsemblGenomes-Gn:BSU08720" /db_xref="EnsemblGenomes-Tr:CAB12700" /db_xref="GOA:Q796Y8" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12226" /db_xref="UniProtKB/Swiss-Prot:Q796Y8" /translation="MTIEIGQKAPDLELKGDHGETVKLSDYKGKYIVLYFYPKDMTPG CTTEACDFRDSHESFAELDAVIIGVSPDSQEKHGKFKEKHNLPFLLLVDDEHKLAEAF DVWKLKKNFGKEYMGIERSTFLIDKEGRLIKEWRKVKVKDHVAEALQTLKDMSEK*" /label="bcp CDS" gene 868116..868589 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /label="bcp gene" promotor_-35 868626..868633 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 868648..868667 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 868654 /Source="Nicolas_upshifts" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="upshifts" CDS 868712..869149 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1580225, 16541078, 16925555, 22194458, 27935957, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1580225, 16541078, 16925555, 22194458, 27935957, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Fur family)" /protein_id="NP_388753.1" /db_xref="EnsemblGenomes-Gn:BSU08730" /db_xref="EnsemblGenomes-Tr:CAB12701" /db_xref="GOA:P71086" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FE3" /db_xref="PDB:2RGV" /db_xref="PDB:3F8N" /db_xref="SubtiList:BG12227" /db_xref="UniProtKB/Swiss-Prot:P71086" /translation="MAAHELKEALETLKETGVRITPQRHAILEYLVNSMAHPTADDIY KALEGKFPNMSVATVYNNLRVFRESGLVKELTYGDASSRFDFVTSDHYHAICENCGKI VDFHYPGLDEVEQLAAHVTGFKVSHHRLEIYGVCQECSKKENH*" /label="perR CDS" gene 868712..869149 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /label="perR gene" downshifts 869131 /Source="Nicolas_upshifts" /id="D437" /incds=0 /nref=149 /ntot=247 /MaxReadThrough="3.98479" /MaxDrop="7.52234" /score="1.62878623" /energy="-12.3" /TU="U670,U671" /idTUdmin="U670" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(869184..869537) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_054575.1" /db_xref="EnsemblGenomes-Gn:BSU08740" /db_xref="EnsemblGenomes-Tr:CAE01450" /db_xref="GOA:Q7WY74" /db_xref="InterPro:IPR020912" /db_xref="SubtiList:BG14192" /db_xref="UniProtKB/Swiss-Prot:Q7WY74" /translation="MAKYSSKINKIRTFALSLVFVGFIIMYIGIFFKESVLLSSLFMI LGLLSIGLSTVVYFWIGMLSTKAVRVICPGCDKETKVLGVVDMCMHCREPLTLDKGLE GKEFDESYNKKKMSK*" /label="ygzB CDS" gene complement(869184..869537) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /label="ygzB gene" downshifts 869197 /Source="Nicolas_upshifts" /id="D438" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="2.62283" /MaxDrop="4.13562" /score="-4.23596421" /energy="-12.5" /TU="NA" /idTUdmin="U670" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(869207) /Source="Nicolas_upshifts" /id="D439" /incds=0 /nref=182 /ntot=253 /MaxReadThrough="4.02571" /MaxDrop="6.23378" /score="9.51667757" /energy="-14.2" /TU="NA" /idTUdmin="U673" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 869533..869537 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-35" promotor_-10 869545..869559 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-10" misc_feature complement(869549..869568) /Source="Nicolas_upshift_promotors" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 869549..869640 /Source="Nicolas_S_feature" /locus_tag="new_945324_945415" /HighExp="Cold, C30, H2O2, Etha, dia15, G135, Paraq, C90, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S302" upshifts 869549 /Source="Nicolas_upshifts" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="upshifts" upshifts complement(869559) /Source="Nicolas_upshifts" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 869617..869620 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-35" promotor_-10 869635..869654 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-10" S_feature 869642..869744 /Source="Nicolas_S_feature" /locus_tag="new_945417_945519" /HighExp="BMM, Cold, LBGstat, C30, Oxctl, LBGexp, Paraq, G180, Lbexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.996, 0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S303" upshifts 869642 /Source="Nicolas_upshifts" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="upshifts" CDS 869745..870629 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388755.1" /db_xref="EnsemblGenomes-Gn:BSU08750" /db_xref="EnsemblGenomes-Tr:CAB12703" /db_xref="InterPro:IPR029348" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10951" /db_xref="UniProtKB/Swiss-Prot:Q04385" /translation="MENLLRPIYQERASHPNTLAVIMIERRNKTSSLTDNFDAALLVI VKDADEPVFIKHYEFDHQTASLHVVTDSQIQEWILLGTNRRIIDWIVNGRVLFDRNEY VVELIDRLNTFPFAERKLKIGLEYGKLIRRYVEGKAFFEANQFLDAYNAVVHALHHLA RIEVIDRGFHPETTVWSQVRQMEPQVYKLYSELIESHESLEKRLELLFLANDFLIHSK AEIGSAHLFEVMKEKDIWQFGELLQHHDLKHFTQDLGVMLDYLTEKGLINVCQIETKG QAVYHRGYSFKKGVDSDS*" /label="ygxA CDS" gene 869745..870629 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /label="ygxA gene" promotor_-35 870612..870619 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 870633..870652 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 870648..870920 /Source="Nicolas_S_feature" /locus_tag="new_946423_946695" /HighExp="LBGstat, Oxctl, C30, Paraq, GM 120, H2O2, HPh, G150, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.106881" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="Sig-" /TUlongPSig="0.0739" /label="S304" upshifts 870648 /Source="Nicolas_upshifts" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(870681) /Source="Nicolas_upshifts" /id="D440" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="2.70619" /MaxDrop="3.85046" /score="4.43428373" /energy="-7.8" /TU="NA" /idTUdmin="U673" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" rRNA 870921..872475 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-16S rRNA" gene 870921..872475 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /label="rrnD-16S gene" rRNA 872643..875570 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-23S rRNA" gene 872643..875570 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /label="rrnD-23S gene" S_feature 875571..875656 /Source="Nicolas_S_feature" /locus_tag="new_951346_951431" /HighExp="G135, C30, Oxctl, Paraq, LBGstat, dia0, HiTm, Fru, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S305" promotor_-35 875632..875639 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 875653..875672 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 875658 /Source="Nicolas_upshifts" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="upshifts" rRNA 875682..875797 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-5S rRNA" gene 875682..875797 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /label="rrnD-5S gene" tRNA 875807..875881 /gene="asnTA" /locus_tag="BSU_tRNA_29" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="asparagine transfer RNA (GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="asnTA tRNA" gene 875807..875881 /gene="asnTA" /locus_tag="BSU_tRNA_29" /label="asnTA gene" tRNA 875887..875978 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Ser tRNA" gene 875887..875978 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /label="trnD-Ser gene" downshifts 875974 /Source="Nicolas_upshifts" /id="D441" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="7.64297" /MaxDrop="4.37505" /score="-9.7424199" /energy="-11" /TU="U676" /idTUdmin="U677" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" tRNA 876013..876084 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Glu tRNA" gene 876013..876084 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /label="trnD-Glu gene" tRNA 876094..876169 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Val tRNA" gene 876094..876169 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /label="trnD-Val gene" tRNA 876179..876255 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Met tRNA" gene 876179..876255 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /label="trnD-Met gene" tRNA 876267..876343 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Asp tRNA" gene 876267..876343 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /label="trnD-Asp gene" tRNA 876356..876431 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Phe(GAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Phe tRNA" gene 876356..876431 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /label="trnD-Phe gene" tRNA 876437..876509 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Thr tRNA" gene 876437..876509 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /label="trnD-Thr gene" tRNA 876532..876616 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GUA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Tyr tRNA" gene 876532..876616 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /label="trnD-Tyr gene" tRNA 876622..876695 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /product="tRNA-Trp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Trp(CCA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Trp tRNA" gene 876622..876695 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /label="trnD-Trp gene" tRNA 876720..876795 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="transfer RNA-His(GUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-His tRNA" gene 876720..876795 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /label="trnD-His gene" tRNA 876805..876876 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Gln tRNA" gene 876805..876876 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /label="trnD-Gln gene" tRNA 876926..877000 /gene="glyTB" /locus_tag="BSU_tRNA_41" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="glycine transfer RNA (GCC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="glyTB tRNA" gene 876926..877000 /gene="glyTB" /locus_tag="BSU_tRNA_41" /label="glyTB gene" tRNA 877006..877076 /gene="cysTA" /locus_tag="BSU_tRNA_42" /product="tRNA-Cys" /inference="profile:tRNAscan:1.23" /note="cysteine tRNA (GCA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="cysTA tRNA" gene 877006..877076 /gene="cysTA" /locus_tag="BSU_tRNA_42" /label="cysTA gene" tRNA 877084..877172 /gene="leuTA" /locus_tag="BSU_tRNA_43" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine RNA (UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTA tRNA" gene 877084..877172 /gene="leuTA" /locus_tag="BSU_tRNA_43" /label="leuTA gene" S_feature 877173..877249 /Source="Nicolas_S_feature" /locus_tag="new_952948_953024" /HighExp="Paraq, C30, Oxctl, G180, G135, Heat, BMM, LBGexp, dia15, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S306" downshifts 877206 /Source="Nicolas_upshifts" /id="D442" /incds=0 /nref=18 /ntot=231 /MaxReadThrough="5.36857" /MaxDrop="5.05259" /score="16.6649124" /energy="-8.9" /TU="U676" /idTUdmin="U677" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature 877251..877419 /Source="Nicolas_S_feature" /locus_tag="new_953026_953194" /HighExp="Heat, Paraq, BMM, Oxctl, H2O2, Cold, G180, Pyr, C30, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S307" promotor_-35 877376..877383 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 877382 /Source="Nicolas_upshifts" /id="D443" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.84674" /MaxDrop="3.439" /score="35.1424037" /energy="-12.4" /TU="U676" /idTUdmin="U677" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 877397..877416 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 877421 /Source="Nicolas_upshifts" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="upshifts" tRNA 877438..877519 /gene="leuTB" /locus_tag="BSU_tRNA_44" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine tRNA(CAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTB tRNA" gene 877438..877519 /gene="leuTB" /locus_tag="BSU_tRNA_44" /label="leuTB gene" promotor_-10 complement(877455..877472) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(877458) /Source="Nicolas_upshifts" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(877493..877498) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(877528) /Source="Nicolas_upshifts" /id="D444" /incds=0 /nref=5 /ntot=151 /MaxReadThrough="1.64364" /MaxDrop="6.28675" /score="7.71223568" /energy="-12.4" /TU="NA" /idTUdmin="U679" /TUdmin=18 /isTUend="TRUE" /label="downshifts" CDS complement(877598..878374) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9795118, 22142536, 26625291, 28234965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9795118, 22142536, 26625291, 28234965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="protein involved in the control of the cell cycle as a function of the environment" /protein_id="NP_388756.2" /db_xref="EnsemblGenomes-Gn:BSU08760" /db_xref="EnsemblGenomes-Tr:CAB12704" /db_xref="GOA:P71088" /db_xref="InterPro:IPR009776" /db_xref="InterPro:IPR014756" /db_xref="PDB:5CL2" /db_xref="SubtiList:BG12229" /db_xref="UniProtKB/Swiss-Prot:P71088" /translation="MSFFKKLAASAGIGAAKVDTILEKDAYFPGEEVQGTVHVKGGKI AQDIRYIDLQLSTRYVIVKDDEEHRKYATIHSFRVTGSFTIQPGEEHQFPFTFTLPLD TPITVGKVEVAVVTDLDIQGGIDKSDHDRIFVEAHPWIENVLEAIENLGFRLNEADCE QAPYFQRRLPFVQEFEFVPTSGYYRQMLDELELIFLLDEDGLEIIFEVDRRARGLRGW LEEMYNDGEQLVRVRFSQSELEDTEELEEVLEEILDQYAE*" /label="spo0M CDS" gene complement(877598..878374) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /label="spo0M gene" downshifts complement(877612) /Source="Nicolas_upshifts" /id="D445" /incds=0 /nref=9 /ntot=131 /MaxReadThrough="6.06864" /MaxDrop="6.58787" /score="6.75662782" /energy="-7" /TU="U679" /idTUdmin="U679" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(878401..878416) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(878423) /Source="Nicolas_upshifts" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(878429..878438) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 878458..878464 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 878479..878490 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 878482 /Source="Nicolas_upshifts" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="upshifts" CDS 878516..878719 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388757.2" /db_xref="EnsemblGenomes-Gn:BSU08770" /db_xref="EnsemblGenomes-Tr:CAB12705" /db_xref="SubtiList:BG12981" /db_xref="UniProtKB/Swiss-Prot:O31586" /translation="MEVNKESLVADELHRMFLAGELQITVEEDINNISERLRNGDLSL DRLSGEDVFIKETVNEALRRVEQ*" /label="ygzA CDS" gene 878516..878719 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /label="ygzA gene" downshifts 878702 /Source="Nicolas_upshifts" /id="D446" /incds=0 /nref=22 /ntot=97 /MaxReadThrough="1.47004" /MaxDrop="5.47861" /score="15.4081475" /energy="-18.2" /TU="NA" /idTUdmin="U676" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(878778) /Source="Nicolas_upshifts" /id="D447" /incds=0 /nref=10 /ntot=35 /MaxReadThrough="1.31339" /MaxDrop="4.8918" /score="26.0684119" /energy="-18.2" /TU="NA" /idTUdmin="U681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(878804..879076) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="YP_003097696.1" /db_xref="EnsemblGenomes-Gn:BSU08779" /db_xref="EnsemblGenomes-Tr:CAX52583" /db_xref="GOA:C0H3X8" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="UniProtKB/Swiss-Prot:C0H3X8" /translation="MYRSKKQSQILSYQELLKKQRRWFPIEQSLCPKDILDLLTTIKT SINKYTVATTATENPHIRRALHDQLDTAVYLHDELSDLLLEKGWLG*" /label="ygzC CDS" gene complement(878804..879076) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /label="ygzC gene" promotor_-10 complement(879035..879053) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(879042) /Source="Nicolas_upshifts" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 879057..879064 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-35" promotor_-35 complement(879070..879075) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 879077..879096 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-10" upshifts 879085 /Source="Nicolas_upshifts" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="upshifts" CDS 879118..879810 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase" /protein_id="NP_388758.2" /db_xref="EnsemblGenomes-Gn:BSU08780" /db_xref="EnsemblGenomes-Tr:CAB12706" /db_xref="GOA:P71089" /db_xref="InterPro:IPR005320" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12230" /db_xref="UniProtKB/Swiss-Prot:P71089" /translation="MKQIIAMGGGGFSMEPDNLSLDQYILNQSKREQPRICFLPTASG DSQNYIQRFYHAFQTLDCVPSHLSLFKPPSSDLVSFVMEMDVIYVGGGNTRNLLVLWK EWGLDHILREAWKNGVVVAGISAGAICWFEEGVTDSAGPLTSLKSLGFLQGSFCPHYD GEKDRRPAYHQLISNKFLCSGYAADDGAALHFINDQLFQTVSSRSGAKAYRVMMAEHE IAEIPLPVKYLG*" /label="ygaJ CDS" gene 879118..879810 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /label="ygaJ gene" promotor_-35 879839..879843 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(879842..879861) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(879854) /Source="Nicolas_upshifts" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 879857..879876 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(879876..879883) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA 879880..879987 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswD RNA" gene 879880..879987 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /label="tswD gene" upshifts 879887 /Source="Nicolas_upshifts" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="upshifts" downshifts 880018 /Source="Nicolas_upshifts" /id="D448" /incds=0 /nref=13 /ntot=48 /MaxReadThrough="8.09735" /MaxDrop="5.74046" /score="17.5556194" /energy="-12.4" /TU="U684" /idTUdmin="U682" /TUdmin=152 /isTUend="FALSE" /label="downshifts" CDS 880120..881892 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /EC_number="4.1.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8432721, 9370266, 10382260, 16291685, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8432721, 9370266, 10382260, 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine synthase" /protein_id="NP_388759.2" /db_xref="EnsemblGenomes-Gn:BSU08790" /db_xref="EnsemblGenomes-Tr:CAB12707" /db_xref="GOA:P45740" /db_xref="InterPro:IPR002817" /db_xref="InterPro:IPR025747" /db_xref="SubtiList:BG11246" /db_xref="UniProtKB/Swiss-Prot:P45740" /translation="MQNNSVQQANISIMSSFSGSKKVYVEGSSSDIQVPMREIALSPT TGSFGEEENAPVRVYDTSGPYTDPEVTINIQEGLKPLRQKWITERGDVEEYEGRAIKP EDNGYKKAKPNVSYPGLKRKPLRAKAGQNVTQMHYAKKGIITPEMEFIAIREHVSPEF VRDEVASGRAIIPSNINHPESEPMIIGRNFHVKINANIGNSAVTSSIEEEVEKMTWAI RWGADTMMDLSTGKDIHTTREWIIRNCPVPVGTVPIYQALEKVNGVAEDLTWEIYRDT LIEQAEQGVDYFTIHAGVLLRYVPLTAKRTTGIVSRGGAIMAQWCLAHHQESFLYTHF EEICEIMKMYDIAFSLGDGLRPGSIADANDEAQFAELETLGELTQIAWKHDVQVMIEG PGHVPMHKIKENVDKQMDICKEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTAM LCYVTPKEHLGLPNRDDVREGVITYKIAAHAADLAKGHPGAQIRDDALSKARFEFRWR DQFNLSLDPERALEYHDETLPAEGAKTAHFCSMCGPKFCSMRISQDIRDYAKKNDLSE AEAINKGLKEKAKEFVDTGSNLYQ*" /label="thiC CDS" gene 880120..881892 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /label="thiC gene" downshifts 881868 /Source="Nicolas_upshifts" /id="D449" /incds=0 /nref=166 /ntot=257 /MaxReadThrough="5.77069" /MaxDrop="5.3684" /score="25.2366359" /energy="-15.3" /TU="U684" /idTUdmin="U684" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature 881913..882838 /Source="Nicolas_S_feature" /locus_tag="new_957688_958613" /HighExp="HiOs, GM-0.1, GM 45, GM 60, GM-0.2, BMM, MG 90, T-5.40H, MG 15, MG 25" /AntisenseName="ygaK" /AntisenseCor="-9.7288827054566707E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="SigA" /TUlongPSig=1 /label="S308" CDS complement(881930..883285) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /EC_number="1.21.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8972604; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FAD-dependent oxido-reductase" /protein_id="NP_388760.2" /db_xref="EnsemblGenomes-Gn:BSU08800" /db_xref="EnsemblGenomes-Tr:CAB12708" /db_xref="GOA:Q796Y5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12231" /db_xref="UniProtKB/Swiss-Prot:Q796Y5" /translation="MEKTKLTGRIVTRDDPDYNEARTNINLSLERYPDIIVFCQNKQD ALNALKWARENRVPFRIRGGRHSYENFSLLNNGLVIDLSEMKKITVNQDKKLAYIEAG AELGEVYRTLWQYGLTLPAGTIANVGLTGLTLGGGIGLLTRAAGLTCDSLVQLEMIVA DEKEGADLITVSCSNHPDLFWASQGGGGGNFGIVTSMTFKAVPISQVSIFSITWGWDD FEEVYNTWQNWAPYTDDRLTSSIEFWPKEVNRIEALGQFVGPKTELKKLLKPLLKAGS PTSGMVKTTPFIEAVTFFNSPGGNQPQKMKRSGSFIEKPLSERAISTIKHFLEHAPNQ NASVWQQALGGAAGRVAPDQTAFYYRDAIIAQEYLTNWTSPGEKRQNVRWIEGLRTSL SKETMGDYVNWPDIEIRNWPRTYYGENVERLRRVKTTYDPENVFRFEQSIPPLRRSLF F*" /label="ygaK CDS" gene complement(881930..883285) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /label="ygaK gene" promotor_-10 complement(883313..883332) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(883330) /Source="Nicolas_upshifts" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(883346..883355) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 883403..883409 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 883424..883443 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 883452 /Source="Nicolas_upshifts" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="upshifts" CDS 883536..883733 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1479343, 2108127, 8323536, 16321961" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1479343, 2108127, 8323536, 16321961; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (repressor of ScoC)" /protein_id="NP_388761.2" /db_xref="EnsemblGenomes-Gn:BSU08810" /db_xref="EnsemblGenomes-Tr:CAB12709" /db_xref="GOA:P21344" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG10747" /db_xref="UniProtKB/Swiss-Prot:P21344" /translation="MGVKKEKGRKRFRKRKTYGNQILPLELLIEKNKREIINSAELME EIYMKIDEKHTQCVTKYKKTR*" /label="senS CDS" gene 883536..883733 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /label="senS gene" CDS complement(883760..885211) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /EC_number="1.11.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 12486061, 16535198, 22194458, 27935957" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12486061, 16535198, 22194458, 27935957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vegetative catalase 1" /protein_id="NP_388762.2" /db_xref="EnsemblGenomes-Gn:BSU08820" /db_xref="EnsemblGenomes-Tr:CAB12710" /db_xref="GOA:P26901" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG10849" /db_xref="UniProtKB/Swiss-Prot:P26901" /translation="MSSNKLTTSWGAPVGDNQNSMTAGSRGPTLIQDVHLLEKLAHFN RERVPERVVHAKGAGAHGYFEVTNDVTKYTKAAFLSEVGKRTPLFIRFSTVAGELGSA DTVRDPRGFAVKFYTEEGNYDIVGNNTPVFFIRDAIKFPDFIHTQKRDPKTHLKNPTA VWDFWSLSPESLHQVTILMSDRGIPATLRHMHGFGSHTFKWTNAEGEGVWIKYHFKTE QGVKNLDVNTAAKIAGENPDYHTEDLFNAIENGDYPAWKLYVQIMPLEDANTYRFDPF DVTKVWSQKDYPLIEVGRMVLDRNPENYFAEVEQATFSPGTLVPGIDVSPDKMLQGRL FAYHDAHRYRVGANHQALPINRARNKVNNYQRDGQMRFDDNGGGSVYYEPNSFGGPKE SPEDKQAAYPVQGIADSVSYDHYDHYTQAGDLYRLMSEDERTRLVENIVNAMKPVEKE EIKLRQIEHFYKADPEYGKRVAEGLGLPIKKDS*" /label="katA CDS" gene complement(883760..885211) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /label="katA gene" downshifts complement(883770) /Source="Nicolas_upshifts" /id="D450" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="1.32399" /MaxDrop="8.8938" /score="25.1548262" /energy="-8.3" /TU="NA" /idTUdmin="U688" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 885188..885194 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 885209..885228 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 885212 /Source="Nicolas_upshifts" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(885229..885248) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 885234..885563 /Source="Nicolas_S_feature" /locus_tag="new_961009_961338" /HighExp="S8, C30, S7, S6, BT, C90, B36, S4, S5, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.528" /TUlongSig="NA" /TUlongPSig="NA" /label="S309" upshifts complement(885248) /Source="Nicolas_upshifts" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(885262..885269) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(885307..885325) /Source="Nicolas_upshift_promotors" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(885332) /Source="Nicolas_upshifts" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" downshifts 885520 /Source="Nicolas_upshifts" /id="D451" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="5.89897" /MaxDrop="4.66837" /score="39.0049465" /energy="-19.7" /TU="U687" /idTUdmin="U686" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" CDS 885619..886386 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (ATP-bindingprotein)" /protein_id="NP_388763.3" /db_xref="EnsemblGenomes-Gn:BSU08830" /db_xref="EnsemblGenomes-Tr:CAB12711" /db_xref="GOA:P97027" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017875" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12232" /db_xref="UniProtKB/Swiss-Prot:P97027" /translation="MAVTISIKEKAFVQEGRKNTVLENIELSIAPGEFLTLIGPSGCG KSTLLKIIAGLDSEYDGSVEINGRSVTAPGIQQGFIFQEHRLFPWLTVEQNIAADLNL KDPKVKQKVDELIEIVRLKGSEKAYPRELSGGMSQRVAIARALLREPEVLLLDEPFGA LDAFTRKHLQDVLLDIWRKKKTTMILVTHDIDESVYLGNELAILKAKPGKIHKLMPIH LAYPRNRTTPDFQAIRQRVLSEFEKTEDLEYAEGSGI*" /label="ssuB CDS" gene 885619..886386 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /label="ssuB gene" CDS 886404..887402 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type f: factor" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (binding lipoprotein)" /protein_id="NP_388764.1" /db_xref="EnsemblGenomes-Gn:BSU08840" /db_xref="EnsemblGenomes-Tr:CAB12712" /db_xref="GOA:P40400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR010067" /db_xref="InterPro:IPR015168" /db_xref="SubtiList:BG10656" /db_xref="UniProtKB/Swiss-Prot:P40400" /translation="MKKGLIVLVAVIFLLAGCGANGASGDHKQLKEIRIGIQQSLSPL LIAKEKGWFEDAFEKEGIKVKWVEFQSGPPQFEGLAADKLDFSQVGNSPVIAGQAAGI DFKEIGLSQDGLKANGILVNQNSGIQDVKGLKGKKIAVAKGSSGFDFLYKALDQVGLS ANDVTIIQLQPDEAASAFENGSVDAWSIWEPYLSLETMKHGAKILVNGESTDLYSPGF TLVRTKFSEEHPDEVVRFLKVFNKAVVWQKEHLDEAADLYSDIKDLDKKVVENVLKNT EPLNEIISDDIVKAQQETADFQFRTKAIDKKIDVKDVVDNTFIKKALEEHSSGGDQ*" /label="ssuA CDS" gene 886404..887402 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /label="ssuA gene" CDS 887399..888229 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11390694, 15849754, 16513748, 16850406, 16885442, 9782504" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15849754, 16513748, 16850406, 16885442, 9782504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (permease)" /protein_id="NP_388765.1" /db_xref="EnsemblGenomes-Gn:BSU08850" /db_xref="EnsemblGenomes-Tr:CAB12713" /db_xref="GOA:P40401" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10657" /db_xref="UniProtKB/Swiss-Prot:P40401" /translation="MMKAEAAGSLPKTNAEAVRKKPGRKRYGWMKGLLLPAVIIAIWQ VIGGLGVVSATVLPTPVTIVLTFKELILSGELFGHLQISIYRAALGFLLGAGLGLMIG ILAGFSKRTELYLDPSLQMLRTVPHLAVTPLFILWFGFDEVSKILLIALGAFFPVYIN TFNGIRGVDAKLFEVARVLEFKWHQQISKVILPAALPNILLGIRLSLGIAWLGLVVAE LMGSSSGVGYMIMDARQFSQTNKVFAGIIIFAVVGKLTDSFVRLLERKLLKWRNSYEG *" /label="ssuC CDS" gene 887399..888229 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /label="ssuC gene" CDS 888252..889382 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /EC_number="1.14.14.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9782504, 11390694, 16513748, 16885442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMNH2-dependent aliphatic sulfonate monooxygenase" /protein_id="NP_388766.2" /db_xref="EnsemblGenomes-Gn:BSU08860" /db_xref="EnsemblGenomes-Tr:CAB12714" /db_xref="GOA:P40402" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019911" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10658" /db_xref="UniProtKB/Swiss-Prot:P40402" /translation="MEILWFIPTHGDARYLGSESDGRTADHLYFKQVAQAADRLGYTG VLLPTGRSCEDPWLTASALAGETKDLKFLVAVRPGLMQPSLAARMTSTLDRISDGRLL INVVAGGDPYELAGDGLFISHDERYEATDEFLTVWRRLLQGETVSYEGKHIKVENSNL LFPPQQEPHPPIYFGGSSQAGIEAAAKHTDVYLTWGEPPEQVKEKIERVKKQAAKEGR SVRFGIRLHVIARETEQEAWEAAERLISHLDDDTIAKAQAALSRYDSSGQQRMAVLHQ GDRTKLEISPNLWAGIGLVRGGAGTALVGDPQTIADRIAEYQALGIESFIFSGYPHLE EAYYFAELVFPLLPFENDRTRKLQNKRGEAVGNTYFVKEKNA*" /label="ssuD CDS" gene 888252..889382 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /label="ssuD gene" misc_feature 889409..889428 /Source="Nicolas_upshift_promotors" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 889415 /Source="Nicolas_upshifts" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="upshifts" CDS 889486..890022 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur-related oxidoreductase" /protein_id="NP_388767.1" /db_xref="EnsemblGenomes-Gn:BSU08870" /db_xref="EnsemblGenomes-Tr:CAB12715" /db_xref="SubtiList:BG12233" /db_xref="UniProtKB/Swiss-Prot:P97028" /translation="MLSACGHSKQMEIKAADISDLEKNRMDVAASQAFTAEAVNIGEG ISSADMYIEHYQKGKLVERFGPVRADYSEEKTDTIQFVYFENEEGEGKNKHTTIHFGI VDKQGTIAADSSVKRDDSTTQEMTQNISSPEPITFEKPALIGSSIRGTDETMHTSEHK KELIKHQDALLYYVELHH*" /label="ygaN CDS" gene 889486..890022 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /label="ygaN gene" S_feature 890023..890093 /Source="Nicolas_S_feature" /locus_tag="new_965798_965868" /HighExp="B36, BT, B60, Etha, S5, Heat, S2, BMM, S4, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25357200000000002" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S310" promotor_-35 890063..890070 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 890084..890103 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 890095 /Source="Nicolas_upshifts" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="upshifts" CDS 890134..890403 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 17163968, 19648245, 20208344, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="alternative ribosomal protein S14" /protein_id="NP_388768.1" /db_xref="EnsemblGenomes-Gn:BSU08880" /db_xref="EnsemblGenomes-Tr:CAB12716" /db_xref="GOA:O31587" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023036" /db_xref="SubtiList:BG13085" /db_xref="UniProtKB/Swiss-Prot:O31587" /translation="MAKKSKVAKELKRQQLVEQYAGIRRELKEKGDYEALSKLPRDSA PGRLHNRCMVTGRPRAYMRKFKMSRIAFRELAHKGQIPGVKKASW*" /label="rpsNB CDS" gene 890134..890403 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /label="rpsNB gene" promotor_-35 890206..890210 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 890233..890249 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 890249 /Source="Nicolas_upshifts" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 890390 /Source="Nicolas_upshifts" /id="D452" /incds=0 /nref=41 /ntot=70 /MaxReadThrough="3.14088" /MaxDrop="6.23701" /score="18.4402235" /energy="-10.1" /TU="U692" /idTUdmin="U691" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(890421..890894) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388769.1" /db_xref="EnsemblGenomes-Gn:BSU08890" /db_xref="EnsemblGenomes-Tr:CAB12717" /db_xref="GOA:P97029" /db_xref="SubtiList:BG12234" /db_xref="UniProtKB/Swiss-Prot:P97029" /translation="MSMKTKAAFHLVLFGLACWALISYFEASEGIASFFGTKSGGMVF DLNLTPFILFVAASAVYLYLQKKSRPARKQLLLPDEFEEQDEREQMMTAKACRASYIA VYFSLPAAAVLLIFYPLFQSRIPFFPIIIVFIIMIIQHLSYVISFKKNEKNSGAL*" /label="ygaO CDS" gene complement(890421..890894) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /label="ygaO gene" downshifts complement(890457) /Source="Nicolas_upshifts" /id="D453" /incds=0 /nref=105 /ntot=235 /MaxReadThrough="1.59724" /MaxDrop="4.17785" /score="7.33161195" /energy="-10.1" /TU="NA" /idTUdmin="U693" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(890896..891096) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative HTH-type transcriptional regulator" /protein_id="YP_003097697.1" /db_xref="EnsemblGenomes-Gn:BSU08899" /db_xref="EnsemblGenomes-Tr:CAX52584" /db_xref="GOA:C0H3X9" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="UniProtKB/Swiss-Prot:C0H3X9" /translation="MKNKVKELRARFGYSQEKLGETVGVTRQTVAAIEKGDYVPSLLL ALKICKAFSMKMEDVFWLEEEN*" /label="ygzD CDS" gene complement(890896..891096) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /label="ygzD gene" promotor_-10 complement(891125..891144) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(891139) /Source="Nicolas_upshifts" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(891157..891164) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 891220..891225 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 891239..891258 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 891239 /Source="Nicolas_upshifts" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="upshifts" tRNA 891290..891363 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(TCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gly1 tRNA" gene 891290..891363 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /label="trnSL-Gly1 gene" S_feature 891364..891546 /Source="Nicolas_S_feature" /locus_tag="new_967139_967321" /HighExp="G135, G180, Oxctl, G150, Paraq, H2O2, C30, HPh, LPh, LBGexp" /AntisenseName="yhzB" /AntisenseCor="0.42714037049296899" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S311" CDS complement(891454..892077) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388771.1" /db_xref="EnsemblGenomes-Gn:BSU08900" /db_xref="EnsemblGenomes-Tr:CAB12718" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG13086" /db_xref="UniProtKB/Swiss-Prot:O31588" /translation="MNIKLDSVITERAAGLHAAAVIYENIEVGSSPQMLKGRLRLFQE SLFFDYADGGISDESFVKEWQKLFKQLNPSFEGETTPMEDMLVPISKEQFMESKDSAH DTIDFFALKYSLPIMIYDAGKLHEPVRISLGEKENILLFSDENGIFGDFKNSVNHYPV SNETKNMLQIIFFPPSIEKSSAVNLLSSLTKMFEQIHGGTHTVHWLT*" /label="yhzB CDS" gene complement(891454..892077) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /label="yhzB gene" downshifts complement(891469) /Source="Nicolas_upshifts" /id="D454" /incds=0 /nref=25 /ntot=165 /MaxReadThrough="2.50849" /MaxDrop="4.62652" /score="-8.52782087" /energy="-7.9" /TU="NA" /idTUdmin="U695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 891503 /Source="Nicolas_upshifts" /id="D455" /incds=0 /nref=1 /ntot=88 /MaxReadThrough="4.14204" /MaxDrop="2.36986" /score="16.0836885" /energy="-15.5" /TU="U694" /idTUdmin="U692" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" S_feature 891548..892159 /Source="Nicolas_S_feature" /locus_tag="new_967323_967934" /HighExp="G180, G135, G150, Paraq, Oxctl, H2O2, LBGstat, Cold, LBGexp, S6" /AntisenseName="yhzB" /AntisenseCor="0.28959466335762701" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S312" promotor_-10 complement(892101..892120) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(892122) /Source="Nicolas_upshifts" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(892134..892141) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 892160..893320 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /EC_number="1.17.99.-" /function="10.3: tRNA and rRNA base modification" /experiment="publication(s) with functional evidences, PMID:8830270, 21502530, 26230193, 27638883, 28128549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830270, 21502530, 26230193, 27638883, 28128549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epoxyqueuosine reductase" /protein_id="NP_388772.2" /db_xref="EnsemblGenomes-Gn:BSU08910" /db_xref="EnsemblGenomes-Tr:CAB12719" /db_xref="GOA:P97030" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR004453" /db_xref="InterPro:IPR013542" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="PDB:5D08" /db_xref="PDB:5D0A" /db_xref="PDB:5D0B" /db_xref="PDB:5T8Y" /db_xref="SubtiList:BG12236" /db_xref="UniProtKB/Swiss-Prot:P97030" /translation="MNVYQLKEELIEYAKSIGVDKIGFTTADTFDSLKDRLILQESLG YLSGFEEPDIEKRVTPKLLLPKAKSIVAIALAYPSRMKDAPRSTRTERRGIFCRASWG KDYHDVLREKLDLLEDFLKSKHEDIRTKSMVDTGELSDRAVAERAGIGFSAKNCMITT PEYGSYVYLAEMITNIPFEPDVPIEDMCGSCTKCLDACPTGALVNPGQLNAQRCISFL TQTKGFLPDEFRTKIGNRLYGCDTCQTVCPLNKGKDFHLHPEMEPDPEIAKPLLKPLL AISNREFKEKFGHVSGSWRGKKPIQRNAILALAHFKDASALPELTELMHKDPRPVIRG TAAWAIGKIGDPAYAEELEKALEKEKDEEAKLEIEKGIELLKASGMTKQGLS*" /label="queG CDS" gene 892160..893320 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /label="queG gene" downshifts 893329 /Source="Nicolas_upshifts" /id="D456" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="5.29174" /MaxDrop="3.3561" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 893346..893358 /Source="Nicolas_upshift_promotors" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 893351 /Source="Nicolas_upshifts" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="upshifts" CDS 893387..894322 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388773.1" /db_xref="EnsemblGenomes-Gn:BSU08920" /db_xref="EnsemblGenomes-Tr:CAB12720" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG11811" /db_xref="UniProtKB/Swiss-Prot:O31589" /translation="MAGGVSLKYILEQLAEERLGFLVNGHAMRQESQVGDLKVMERKK KLLEKRKVDIIKAKAKAVINHVRVEDDGTTCLSYTIHYEYVCKEQDDSLYIEEHIEER MAFLYDHILISDQEIAKKPAGFHEGTSIIDYSEAEEEREAFGRAFQYDRLGAVQYAEK FWNKRNPAYKNFSDNCTNFISQCLHAGGAPMRGHPNRGSGWWMKQSSWSYSWTVAHSM KMYLSNSKAGLRAVRVKSAEELMPGDVICYDFEGDGRFNHTTIVVAKDKGNMPLVNAQ TYDSRMRYWSYEDSTAYTPSIRYAFFHIVDDTTKE*" /label="yhbB CDS" gene 893387..894322 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /label="yhbB gene" downshifts complement(893405) /Source="Nicolas_upshifts" /id="D457" /incds=0 /nref=2 /ntot=17 /MaxReadThrough="2.06584" /MaxDrop="3.33944" /score="-3.35852865" /energy="-6" /TU="NA" /idTUdmin="U695" /TUdmin="-1936" /isTUend="FALSE" /label="downshifts" promotor_-35 894306..894309 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 894324 /Source="Nicolas_upshifts" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 894325..894344 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 894360..894842 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /EC_number="2.1.1.207" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 20855540; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (cytidine(34)-2'-O)-methyltransferase" /protein_id="NP_388774.2" /db_xref="EnsemblGenomes-Gn:BSU08930" /db_xref="EnsemblGenomes-Tr:CAB12721" /db_xref="GOA:O31590" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR016914" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG11802" /db_xref="UniProtKB/Swiss-Prot:O31590" /translation="MNIVALHVVLYQPEIPANTGNIARTCAATNTTLHLIRPLGFSTD DKMLKRAGLDYWEFVNVVYHDSLEELFEAYKKGKFFFITKFGQQPHTSFDYTDLDEDY FFVFGRETSGLPKDLIQNNMDRCLRLPMTEHVRSLNLSNTAAILVYEALRQQNYRDLK *" /label="trmL CDS" gene 894360..894842 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /label="trmL gene" downshifts 894825 /Source="Nicolas_upshifts" /id="D458" /incds=0 /nref=203 /ntot=259 /MaxReadThrough="4.6846" /MaxDrop="7.03587" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U696" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 894892..895608 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="NP_388775.1" /db_xref="EnsemblGenomes-Gn:BSU08940" /db_xref="EnsemblGenomes-Tr:CAB12722" /db_xref="InterPro:IPR025063" /db_xref="SubtiList:BG12237" /db_xref="UniProtKB/Swiss-Prot:P97032" /translation="MLCFVFGLNNVTVLCYNVPIKGAGLMEEQLISKKELLERTSISY GQLYRWKRKNLIPEEWFIRKSTFTGQETFFPREEILKRISMIQKMKENLSLDEMREML SPKMKDVSMTADELLHKGLVSRPALEAYSEDGGSPVFSSSDLLSLFVLEGLLQSGNVS LAEAKMAAEVLKKHDTEEIEKQTELIVLRKLGVTTCFIAAAADSILFESSVKVVERVD LLKASEELKTTFMQEGHQWM*" /label="yhbD CDS" gene 894892..895608 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /label="yhbD gene" promotor_-35 894912..894919 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 894934..894953 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 894935 /Source="Nicolas_upshifts" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="upshifts" CDS 895599..896312 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388776.1" /db_xref="EnsemblGenomes-Gn:BSU08950" /db_xref="EnsemblGenomes-Tr:CAB12723" /db_xref="InterPro:IPR007607" /db_xref="SubtiList:BG10802" /db_xref="UniProtKB/Swiss-Prot:P39132" /translation="MDVVEKLVINGSGSSKGGTFQSVEINGSGTVAGDVECDTFSFNG NGKADGSVKAKAVTISGSGKIHGDVEAESIRMNGTGFIQGEVSAKQLKIAGSSTFGGT VKADGIDISGKAVMEADCETETFQSEGKCKISGLLNADQVIIKLSAGESYAREIGCRH LQVTCRKGMLTLLRLMPQPVLTAELIEGDVIELTNTKAKTVRGNKVIIGPDCQIETVE YSGDYTCDPSASVETSTKL*" /label="yhbE CDS" gene 895599..896312 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /label="yhbE gene" CDS 896324..897031 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388777.2" /db_xref="EnsemblGenomes-Gn:BSU08960" /db_xref="EnsemblGenomes-Tr:CAB12724" /db_xref="SubtiList:BG10803" /db_xref="UniProtKB/Swiss-Prot:P39133" /translation="METTKLGNLKLYGAGHAAGGAYHNVSIKGEGIVGEGLSAVGCRI YGTGLFLGKAETERLRVLGESECKGDLTAGKINIYGTMKVSGSLQFDRFNLKGQTEIG GNMTGESCDVKGKLSVIGDCETEMFHVTGCVDVSGLLNSGEIKLGLSHDISHVQEIGG TTITVKRRASFFSRKKGKLIADVIEGDRVYLENTEAAVVRGKEVIIGPGCSIGTIEYE YKCECDPHSQIKEKTKL*" /label="yhbF CDS" gene 896324..897031 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /label="yhbF gene" downshifts 896915 /Source="Nicolas_upshifts" /id="D459" /incds=1 /nref=1 /ntot=127 /MaxReadThrough="4.34704" /MaxDrop="2.64409" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 896959 /Source="Nicolas_upshifts" /id="D460" /incds=1 /nref=2 /ntot=35 /MaxReadThrough="4.02504" /MaxDrop="3.21894" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 897025 /Source="Nicolas_upshifts" /id="D461" /incds=0 /nref=2 /ntot=41 /MaxReadThrough="1.06365" /MaxDrop="3.74046" /score="45.497414" /energy="-15.3" /TU="NA" /idTUdmin="U698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(897058..897233) /Source="Nicolas_S_feature" /locus_tag="new_972833_973008_c" /HighExp="M9-stat, BC, S4, T0.30H, LoTm, Lbstat, S2, BT, HiOs, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99846699999999999" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S313" downshifts complement(897101) /Source="Nicolas_upshifts" /id="D462" /incds=0 /nref=63 /ntot=220 /MaxReadThrough="3.38525" /MaxDrop="4.33005" /score="18.2489321" /energy="-13.5" /TU="U699" /idTUdmin="U699" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(897225..897244) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(897233) /Source="Nicolas_upshifts" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(897259..897266) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 897298..897303 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 897319..897337 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 897319 /Source="Nicolas_upshifts" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 897381..899276 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8626065, 12662922, 25983726, 27806131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8626065, 12662922, 25983726, 27806131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine protein kinase (involved in sporulation)" /protein_id="NP_388778.1" /db_xref="EnsemblGenomes-Gn:BSU08970" /db_xref="EnsemblGenomes-Tr:CAB12725" /db_xref="GOA:P39134" /db_xref="InterPro:IPR010650" /db_xref="InterPro:IPR013153" /db_xref="InterPro:IPR016230" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10804" /db_xref="UniProtKB/Swiss-Prot:P39134" /translation="MDILKKIEKYREEEQRLKWEGTFADYLEIIKENPMVAQSAHSRV FNMIKDSGIEEIDGRKKYSFFDRELFGLEESLERLVEEYFHPAAKRLDVRKRILLLMG PVSGGKSTLVTMLKKGLEAYTLTDNGAVYAIKGCPMHEDPLHLIPHHLRDDFYREYGI RIEGSLSPLNVMRLEEEYGGRIEDVKVERIFFSEDKRTGIGTFSPSDPKSQDIADLTG SIDFSTIAEYGSESDPRAYRFDGELNKANRGMMEFQEMLKCDEKFLWHLLSLTQEGNF KAGRFALISADELIVAHTNETEYRSFISNKKNEALHSRIIVMPVPYNLKVSEEERIYE KMIAESDVADVHIAPHTLKVAAMFSILTRLKEPKRSDIDLVKKMRLYDGESVEGYNSV DVEDMKKEYNDEGMSGIDPRYVINRISSTIIRKNMESINSLDVLRSLKEGLDQHPSIS SEDRERYLNFISAARKEYDDIAKKEVQKAFVYSYEESAKTLMDNYLDNVEAYCNKNKL RDPLTGEEMNPDEKLMRSIEEQIGISENAKKAFREEILIRISAYARKGKRFDYNSHER LREAIQKKLFADLKDVVKITTSTKTPDEQQLKKVNEVVARLIDEHGYNSTSANELLKY VGSLLNR*" /label="prkA CDS" gene 897381..899276 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /label="prkA gene" promotor_no_box 897823..897923 /Source="Nicolas_upshift_promotors" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 897883 /Source="Nicolas_upshifts" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 897949 /Source="Nicolas_upshifts" /id="D463" /incds=1 /nref=5 /ntot=18 /MaxReadThrough="7.33384" /MaxDrop="5.65132" /score="45.497414" /energy="-15.3" /TU="U700" /idTUdmin="U701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 899269 /Source="Nicolas_upshifts" /id="D464" /incds=0 /nref=11 /ntot=57 /MaxReadThrough="6.19375" /MaxDrop="4.381" /score="-0.497429548" /energy="-10.6" /TU="U700" /idTUdmin="U703" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 899333..899338 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 899354..899372 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 899357..899455 /Source="Nicolas_S_feature" /locus_tag="new_975132_975230" /HighExp="S6, S7, S5, S8, S4, S3, BT, LoTm, B36, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.971, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S314" upshifts 899357 /Source="Nicolas_upshifts" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 899456..900634 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11988534, 12662922, 14523133, 25983726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 12662922, 14523133, 25983726; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination" /protein_id="NP_388779.1" /db_xref="EnsemblGenomes-Gn:BSU08980" /db_xref="EnsemblGenomes-Tr:CAB12726" /db_xref="InterPro:IPR006698" /db_xref="InterPro:IPR014230" /db_xref="SubtiList:BG11238" /db_xref="UniProtKB/Swiss-Prot:P45742" /translation="MSQNDSGHFLISEENWSLHRKGFDDQQRHQKKVQEAIKNNLPDL VTEESIIMSNGKDVVKIPIRSLDEYKIRYNYDKNKHVGQGDGESQVGDVVARDGSDKK QGPGKGQGAGDQAGEDYYEAEVSLMDLEEALFKELELPNLQQKERDNIIHTDIEFNDI RKTGLTGNIDKKRTMMSAFKRNAMSGKPSFYPIYPEDLKYKTWNDITKPESKAVVLAM MDTSGSMGVWEKYMARSFFFWMTRFLRTKYETVEIEFIAHHTEARVVSEEDFFSKGES GGTICSSVYRKSLELIDEKYNPARYNIYPFHFSDGDNLTSDNARCVKLVNDIMKKANL FCYGEVNQYNRHSTLMSAYKNVKDEKFKYYILKQKSDVFQALKNFFRNEESGVSHQFS *" /label="yhbH CDS" gene 899456..900634 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /label="yhbH gene" promotor_-35 899654..899657 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 899672..899691 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 899676 /Source="Nicolas_upshifts" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(899917) /Source="Nicolas_upshifts" /id="D465" /incds=1 /nref=1 /ntot=23 /MaxReadThrough="2.79078" /MaxDrop="2.94521" /score="-7.1109433" /energy="-11.2" /TU="NA" /idTUdmin="U699" /TUdmin="-3014" /isTUend="FALSE" /label="downshifts" downshifts 900613 /Source="Nicolas_upshifts" /id="D466" /incds=0 /nref=63 /ntot=180 /MaxReadThrough="1.86673" /MaxDrop="8.19565" /score="27.3980811" /energy="-5.6" /TU="NA" /idTUdmin="U702" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 900721..900728 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 900743..900762 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 900743 /Source="Nicolas_upshifts" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 900794..901258 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)induced by acid stress" /protein_id="NP_388780.1" /db_xref="EnsemblGenomes-Gn:BSU08990" /db_xref="EnsemblGenomes-Tr:CAB12727" /db_xref="GOA:O31592" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13003" /db_xref="UniProtKB/Swiss-Prot:O31592" /translation="MTESERALLTFEQLFDTSRAIYKKQKKILEIVLEPFDITVLQYL LMFKIHQSGSTPLSKLAMSLDLKPASVTRMTDILYKRQLMNRYDSPDDRRIVMIQLTE EGEELIEKAAVQYAKMGAGLYQKLDTSQLQYLRKLAGSLTKLAEGCSEKSGN*" /label="yhbI CDS" gene 900794..901258 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /label="yhbI gene" promotor_-35 901083..901089 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 901104..901122 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 901117 /Source="Nicolas_upshifts" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 901267..901273 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 901287..901298 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 901293 /Source="Nicolas_upshifts" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 901294..901959 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane fusion protein; putative exporter subunit (benzoate transcriptome)" /protein_id="NP_388781.1" /db_xref="EnsemblGenomes-Gn:BSU09000" /db_xref="EnsemblGenomes-Tr:CAB12728" /db_xref="GOA:O31593" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG13004" /db_xref="UniProtKB/Swiss-Prot:O31593" /translation="MIEDETKGENKMNRGRLILTNIIGLIVVLAIIAGGAYYYYQSTN YVKTDEAKVAGDMAAITAPAAGKVSDWDLDEGKTVKKGDTVAKIKGEQTVDVKSIMDG TIVKNEVKNGQTVQAGTTIAQTIDMDNLYITANIKETDIADIEVGNSVDVVVDGDPDT TFDGTVEEIGYATNSTFDMLPSTNSSGNYTKVTQKVPVKISIKNPSDKVLPGMNASVK ISE*" /label="yhbJ CDS" gene 901294..901959 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /label="yhbJ gene" CDS 902000..903598 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter (benzoate transcriptome)" /protein_id="NP_388782.1" /db_xref="EnsemblGenomes-Gn:BSU09010" /db_xref="EnsemblGenomes-Tr:CAB12729" /db_xref="GOA:P54585" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11579" /db_xref="UniProtKB/Swiss-Prot:P54585" /translation="MATGKEKNAKNPMSLLIVLMAGLFLAILNQTLLNVAMPHLMTEF GVSATTIQWLTTGYMLVNGVLIPLSAFLITRFGQRSLFLVAMFCFTLGTLVCGIAPNF STMLIGRLIQAVGGGILQPLVMTTILLIFPPESRGKGMGIFGLAMMFAPAVGPTLSGW IIEHYTWRIMFYGLVPIGAIVIIVAFFIFKNMVEPQKIKLDTLGAILSIVGFASLLYG VSEAGSDGWTDPIVLSTVIIGAIAIVAFVVQQLRHDDPMLDFRVFKYDIFSLSSVINI IITVALYTGMFLLPIYLQNLVGFTALQSGLLLLPGAIVMLIMSPISGILFDKFGPRPL AIIGLLVTVVTTYQYTQLTIDTPYTHIMLIYSIRAFGMSLLMMPVMTAGMNQLPARLN SHGTAMSNTLRQISGSIGTSLITTIYTNRTTFHYSQIADKTSTADPNFLHAFQNAVSN LMVNMNVSYDTAKTYVYSHIYKHASLDSNVMGINDAFMWATLFCVAGLILSIFLRDVR KDKLRKKKKEELSLLPAPKEAKES*" /label="yhcA CDS" gene 902000..903598 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /label="yhcA gene" CDS 903621..904151 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /EC_number="1.6.5.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15754243, 18041955, 17951395, 19665595, 20011599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:quinone oxidoreductase associated to benzoate stress" /protein_id="NP_388783.1" /db_xref="EnsemblGenomes-Gn:BSU09020" /db_xref="EnsemblGenomes-Tr:CAB12730" /db_xref="GOA:P54586" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11580" /db_xref="UniProtKB/Swiss-Prot:P54586" /translation="MKIYVVYDSEGEHTKVLAEAIAEGARENDAAEVFIDHVDQADIR KLKDMDAIIWGCPGHFGTISSGLKTWIDRLGYLWAEGELINKVGAVFCTTATTHGGLE MTMHNLITPMFHQGMIVVGLPGNVPENALYGSYYGAGVTCPVDSDELMSEEGIQLGRA LGRRVSQVTGNLTAGQ*" /label="yhcB CDS" gene 903621..904151 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /label="yhcB gene" CDS 904164..904538 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical membrane protein" /protein_id="NP_388784.1" /db_xref="EnsemblGenomes-Gn:BSU09030" /db_xref="EnsemblGenomes-Tr:CAB12731" /db_xref="GOA:P54587" /db_xref="SubtiList:BG11581" /db_xref="UniProtKB/Swiss-Prot:P54587" /translation="MAIIIAIIAAVIVIAALITFNVRNASPGPEKQEATDRIAPPEEE KNEAHYPAEARAAEHTPSVVKNDSPKEKRDTMGDDIYRQALQKFKHSDEVHAEEEVTE ESDKMQDRSYRDALLSMKNKKK*" /label="yhcC CDS" gene 904164..904538 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /label="yhcC gene" downshifts 904527 /Source="Nicolas_upshifts" /id="D467" /incds=0 /nref=32 /ntot=145 /MaxReadThrough="1.78742" /MaxDrop="5.9171" /score="13.777309" /energy="-14.4" /TU="NA" /idTUdmin="U704" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 904538..904693 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388785.1" /db_xref="EnsemblGenomes-Gn:BSU09040" /db_xref="EnsemblGenomes-Tr:CAB12732" /db_xref="SubtiList:BG11582" /db_xref="UniProtKB/Swiss-Prot:P54588" /translation="MKKANPFTHAGLPFLLFPSIMFLSNKSMEYVVFHLDLVYYVTHT PRIFSGR*" /label="yhcD CDS" gene 904538..904693 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /label="yhcD gene" promotor_-35 904628..904634 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 904649..904668 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 904659 /Source="Nicolas_upshifts" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="upshifts" CDS 904698..905459 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane orphan protein" /protein_id="NP_388786.1" /db_xref="EnsemblGenomes-Gn:BSU09050" /db_xref="EnsemblGenomes-Tr:CAB12733" /db_xref="GOA:P54589" /db_xref="SubtiList:BG11583" /db_xref="UniProtKB/Swiss-Prot:P54589" /translation="MNSFLGLLKKDIKLSRMWLLVWICGIIFLLGTGHIIASRTKEPL VIFGFFVAVAFFLLFLSPVFVFYHLRKEGKSQLWLYNPNGGLWLFSSKLAASLLYQFV IQLALTAYGIWMYHMLSVKNLLEHQVDITSTVALLNMYGLISSLDMSVTVIVFWTVFH SLRNWRGMRWAAMVLLVAMWLFFDEYIISPLVESQKHFWPVTVYCNFDFHFHNVWRLE LKPIHLSVLGFPIAIVITFLLLIMASKLLDRKVEV*" /label="yhcE CDS" gene 904698..905459 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /label="yhcE gene" promotor_-10 complement(905011..905029) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(905025) /Source="Nicolas_upshifts" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(905045..905050) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 905462..905827 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388787.1" /db_xref="EnsemblGenomes-Gn:BSU09060" /db_xref="EnsemblGenomes-Tr:CAB12734" /db_xref="GOA:P54590" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11584" /db_xref="UniProtKB/Swiss-Prot:P54590" /translation="MDNQFQSSKPIYLQIADQIFYRLVRKELLPGDKLPSVREMAIQT KVNPNTIQRTYSEMERLGIVETRRGQGTFIAEKAEIVDELKDKLTREVLEGFVKQMKE LGLTKEEMLEGIKTFTEGG*" /label="yhcF CDS" gene 905462..905827 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /label="yhcF gene" CDS 905829..906527 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter ATP-binding protein" /protein_id="NP_388788.1" /db_xref="EnsemblGenomes-Gn:BSU09070" /db_xref="EnsemblGenomes-Tr:CAB12735" /db_xref="GOA:P54591" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11585" /db_xref="UniProtKB/Swiss-Prot:P54591" /translation="MEIKLEHVSKKYGRHTAVNDVSITLSSGRIYGLIGPNGSGKSTT LKMMAGLLFPTSGFVKVDEEQVTREMVRQTAYLTELDMFYPHFTVKDMVNFYQSQFPD FHTEQVYKLLNEMQLNPEKKIKKLSKGNRGRLKIVLALARRADVILLDEPFSGLDPMV RDSIVNSLVSYIDFEQQIVVIATHEIDEIETLLDEVIILANGEKVAQREVEDIREQEG MSVLQWFKSKMEVC*" /label="yhcG CDS" gene 905829..906527 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /label="yhcG gene" CDS 906544..907461 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7476193, 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388789.1" /db_xref="EnsemblGenomes-Gn:BSU09080" /db_xref="EnsemblGenomes-Tr:CAB12736" /db_xref="GOA:P54592" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11586" /db_xref="UniProtKB/Swiss-Prot:P54592" /translation="MKTVLELKNVTKNIRGRTIIDDLSFTIREGEVFGFLGPNGAGKT TTIRMMVGLMKLSKGDVLICGQSITKEYAKAIKHIGAIVENPELYKFLSGYKNLQQFA RMVKGVTKEKIDEVVELVGLTDRIHDKVKTYSLGMRQRLGLAQCLLHDPKVLILDEPT NGLDPAGIREIRDHLKKLTRERGMAVIVSSHLLSEMELMCDRIAILQKGKLIDIQNVK DENIDENDTYFFQVEQPSEAATVLNQYDLLSKTNGVEIKLAKEEVPAVIELLVMQQIR IYEVKVITKSLEDRFLEMTGETKEEVQHA*" /label="yhcH CDS" gene 906544..907461 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /label="yhcH gene" CDS 907454..908395 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15870467, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_388790.1" /db_xref="EnsemblGenomes-Gn:BSU09090" /db_xref="EnsemblGenomes-Tr:CAB12737" /db_xref="GOA:P54593" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11587" /db_xref="UniProtKB/Swiss-Prot:P54593" /translation="MLNLIYNEWLKIFSRAGTWVMIGILGLTMVGFAFLANHFSAGES NSHWKQELQAQNAELKKEIKEDPSLKDGYKETITLNDYRIEHNIPSDTGYTVWSYVTD SANFTILTGLFTIIIAAGIVANEFNWGTIKLLMIRPLSRFQILMSKYITVLLFGLLLL LILFIGSTLLGLIFFGTGGETAANIHLIYKDGHVIEQNMMGHLATTYLSESVSALMVA TMAFMLSAVFRNSSLAVGFSIFLLVAGTTATAFIAAKFDWAKYILFANVDLTQYVDGT PLIKGMTMTFSLVMLAIYFIIFLLLAFGIFMKRDIAN*" /label="yhcI CDS" gene 907454..908395 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /label="yhcI gene" downshifts 908377 /Source="Nicolas_upshifts" /id="D468" /incds=0 /nref=43 /ntot=186 /MaxReadThrough="2.67567" /MaxDrop="4.46232" /score="20.0218504" /energy="-13.6" /TU="NA" /idTUdmin="U707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(908487..908690) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12493834, 16352840, 22128343, 25851716" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12493834, 16352840, 22128343, 25851716; Product type f: factor" /codon_start=1 /transl_table=11 /product="major cold-shock protein, RNA helicase co-factor, RNA co-chaperone" /protein_id="NP_388791.1" /db_xref="EnsemblGenomes-Gn:BSU09100" /db_xref="EnsemblGenomes-Tr:CAB12738" /db_xref="GOA:P32081" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="PDB:1CSP" /db_xref="PDB:1CSQ" /db_xref="PDB:1NMF" /db_xref="PDB:1NMG" /db_xref="PDB:2ES2" /db_xref="PDB:2F52" /db_xref="PDB:2I5L" /db_xref="PDB:2I5M" /db_xref="PDB:3PF4" /db_xref="PDB:3PF5" /db_xref="SubtiList:BG10824" /db_xref="UniProtKB/Swiss-Prot:P32081" /translation="MLEGKVKWFNSEKGFGFIEVEGQDDVFVHFSAIQGEGFKTLEEG QAVSFEIVEGNRGPQAANVTKEA*" /label="cspB CDS" gene complement(908487..908690) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /label="cspB gene" downshifts complement(908501) /Source="Nicolas_upshifts" /id="D469" /incds=0 /nref=169 /ntot=281 /MaxReadThrough="5.28215" /MaxDrop="9.14889" /score="33.2405587" /energy="-13.1" /TU="U710" /idTUdmin="U710" /TUdmin="-48" /isTUend="FALSE" /label="downshifts" S_feature complement(908691..908818) /Source="Nicolas_S_feature" /locus_tag="new_984466_984593_c" /HighExp="BC, C90, GM 15, BI, T-1.10H, UNK1, S1, Sw, nit, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S315" misc_feature 908778..908789 /Source="Nicolas_upshift_promotors" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 908795 /Source="Nicolas_upshifts" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(908807..908826) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(908818) /Source="Nicolas_upshifts" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(908820..909958) /Source="Nicolas_S_feature" /locus_tag="new_984595_985733_c" /HighExp="C30, G180, G150, Oxctl, G135, Paraq, HPh, LPh, dia0, Lbexp" /AntisenseName="yhcJ" /AntisenseCor="0.25433958616302499" /AntisenseRegPval="-4.5999999999999996" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S316" promotor_-35 complement(908840..908845) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 908985..908992 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 909007..909025 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 909014 /Source="Nicolas_upshifts" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 909015..909125 /Source="Nicolas_S_feature" /locus_tag="new_984790_984900" /HighExp="Diami, dia15, dia5, H2O2, Salt, C90, Paraq, UNK1, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S317" CDS 909126..909956 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_388792.2" /db_xref="EnsemblGenomes-Gn:BSU09110" /db_xref="EnsemblGenomes-Tr:CAB12739" /db_xref="GOA:P54594" /db_xref="InterPro:IPR004872" /db_xref="SubtiList:BG11588" /db_xref="UniProtKB/Swiss-Prot:P54594" /translation="MKKWLICSFVLVLLVSFTACSPSAEHESIKIGIAESDGAIWNYI AQKAEEAGLDIQLIPFSDYAESDIALANKEIDANAFQTISYFQSFTEKYKLNLAPLGT TYITPMGIYSKRYERIRDISRGAVVSVPDKAFDFGRALTVLQEAGLLTLKNGFNGTGS VDMIKDNPRHLKLKAVRQQDAVSGADVFVMKPSEAKKAGLNPKKHTLKSGGLMSEEEM NLIVVRAEDQDREALQTILELYQADDTAAFIEKEYQGDLVPAFLPLKRLSDWKNEFEH *" /label="yhcJ CDS" gene 909126..909956 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /label="yhcJ gene" downshifts 909915 /Source="Nicolas_upshifts" /id="D470" /incds=0 /nref=38 /ntot=203 /MaxReadThrough="2.83059" /MaxDrop="3.90173" /score="-4.94928928" /energy="-7.3" /TU="NA" /idTUdmin="U711" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(909959..911038) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_388793.1" /db_xref="EnsemblGenomes-Gn:BSU09120" /db_xref="EnsemblGenomes-Tr:CAB12740" /db_xref="GOA:P54595" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG11589" /db_xref="UniProtKB/Swiss-Prot:P54595" /translation="MLKELFVNLTILITFNYLFTHLFKERLVHKKDSISFQAVKGLAC GLLGVILMVFGFTYQHSIIDLRNIPIMIAALYGGWVSTATALAMITAGRLLITMNTSA LYSVIIICIAAIPSLIVSRRKKVQLKHAFYLLIITNSLISFSFYFLIDLHSYELHLYF WIISIAGGMLSLYIIDHETNAHLLFKQYKFQAHFDFLTGVYNRRKFEETTKALYQQAA DTPHFQFALIYMDIDHFKTINDQYGHHEGDQVLKELGLRLKQTIRNTDPAARIGGEEF AVLLPNCSLDKAARIAERIRSTVSDAPIVLTNGDELSVTISLGAAHYPNNTEQPGSLP ILADQMLYKAKETGRNRVCFSEKKE*" /label="dgcK CDS" gene complement(909959..911038) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /label="dgcK gene" promotor_-10 complement(911048..911067) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-10" upshifts complement(911069) /Source="Nicolas_upshifts" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="upshifts" promotor_-35 complement(911083..911087) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-35" promotor_-35 911145..911152 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 911166..911185 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 911172 /Source="Nicolas_upshifts" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="upshifts" CDS 911211..912602 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12193636, 15262924, 15849754, 16513748, 16850406, 19508281" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 15262924, 15849754, 16513748, 16850406, 19508281; Product type t : transporter" /codon_start=1 /transl_table=11 /product="(sodium)-cystine symporter" /protein_id="NP_388794.1" /db_xref="EnsemblGenomes-Gn:BSU09130" /db_xref="EnsemblGenomes-Tr:CAB12741" /db_xref="GOA:P54596" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11590" /db_xref="UniProtKB/Swiss-Prot:P54596" /translation="METLLVVLHVFILFLLILGLFVMQKKHVSFSKRVFTALGLGIVF GFALQLIYGPTSNIVIQTADWFNIAGGGYVKLLQMVVMPLVFISILGAFTKLKLTKNL GKISGLIIGILVATTAVAAAVGIASALSFDLQAIQVDQGSTELSRGQELQQKSEDMTA KTLPQQIVELLPGNPFLDFTGARPTSTIAVVIFAAFLGVAFLGVKHKQPEQAETFKKL VDAVYAIVMRVVTLILRLTPYGVLAIMTKTIATSDLDSILKLGMFVIASYAALITMFI IHLLLLTFSGLNPVIYLKKAVPVLVFAFTSRSSAGALPLNIKTQRSMGVPEGIANFAG SFGLSIGQNGCAGIYPAMLAMMIAPTVGQNPFDPVFIITVIAVVAISSFGVAGVGGGA TFAALLVLSSLNMPVALAGLLISIEPLIDMGRTALNVSGSMTSGLITSKVTKEIDQGA FHDQSRVIEAEEA*" /label="tcyP CDS" gene 911211..912602 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /label="tcyP gene" S_feature complement(912238..912641) /Source="Nicolas_S_feature" /locus_tag="new_988013_988416_c" /HighExp="S8, S6, Etha, S5, S7, S4, ferm, nit, Salt, S3" /AntisenseName="tcyP" /AntisenseCor="-0.40132140065468203" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S318" downshifts 912581 /Source="Nicolas_upshifts" /id="D471" /incds=0 /nref=58 /ntot=164 /MaxReadThrough="2.37899" /MaxDrop="5.34563" /score="19.9118074" /energy="-12.8" /TU="NA" /idTUdmin="U713" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(912642..913097) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21625606" /codon_start=1 /transl_table=11 /product="expressed protein of unknown function" /protein_id="NP_388795.1" /db_xref="EnsemblGenomes-Gn:BSU09140" /db_xref="EnsemblGenomes-Tr:CAB12742" /db_xref="SubtiList:BG11591" /db_xref="UniProtKB/Swiss-Prot:P54597" /translation="MLFNQRRGISPAALIIGSTMLITALSPQIRQRISGFITGQMNRR NSENNTFDASNVGNMVKQAFSGSSGSSGDNQDRSQHQSQRQNGRQHQHAGQQQPQHQH TQSQTRQTETAAKKRQPHYAEPIHFEQNAMNVMDDNTMMEMLEDLEPGR*" /label="yhcM CDS" gene complement(912642..913097) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /label="yhcM gene" promotor_-10 complement(913112..913130) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(913140) /Source="Nicolas_upshifts" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(913145..913151) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 913189..913195 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 913209..913220 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 913213 /Source="Nicolas_upshifts" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="upshifts" CDS 913247..913816 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9611260, 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_388796.2" /db_xref="EnsemblGenomes-Gn:BSU09150" /db_xref="EnsemblGenomes-Tr:CAB12743" /db_xref="GOA:P54598" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG11592" /db_xref="UniProtKB/Swiss-Prot:P54598" /translation="MFGKKQVLASVLLIPLLMTGCGVADQGEGRRDNNDVRNVNYRNP ANDDMRNVNNRDNVDNNVNDNVNNNRVNDDNNNDRKLEVADEAADKVTDLKEVKHADI IVAGNQAYVAVVLTNGNKGAVENNLKKKIAKKVRSTDKNIDNVYVSANPDFVERMQGY GKRIQNGDPIAGLFDEFTQTVQRVFPNAE*" /label="yhcN CDS" gene 913247..913816 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /label="yhcN gene" promotor_-35 913443..913449 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 913460 /Source="Nicolas_upshifts" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 913463..913474 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 913791 /Source="Nicolas_upshifts" /id="D472" /incds=0 /nref=26 /ntot=183 /MaxReadThrough="1.84697" /MaxDrop="7.80159" /score="33.0647397" /energy="-12.9" /TU="NA" /idTUdmin="U715" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-35 913859..913868 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 913882..913901 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 913892 /Source="Nicolas_upshifts" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="upshifts" CDS 913937..914905 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein (sporulation germination island)" /protein_id="NP_388797.2" /db_xref="EnsemblGenomes-Gn:BSU09165" /db_xref="EnsemblGenomes-Tr:CAB12744" /db_xref="SubtiList:BG11593" /db_xref="UniProtKB/Swiss-Prot:P54599" /translation="MRDGIGKRAASALFLCGVLVMLAVSSAIVSSAMYILSFPGQASG ITKEQVTKHMKKESFKQADIYYTSKEKSLLPLTKETLEYAVSINQIMIGYSNQKPIDI IFFPNEKQMEAYSGLLDVVGFYSEREQLIGLLPEEKKKLLEGDEVAVYLYQRLLIHEY SHHAFHQKLKELETDPDEFPLWFHEGLSEWIANYELLIDPITFSVVPFDRLQTDRDWQ EARAEYDTDVYLQSFYMIDELTDKYGKDIISEMIKETAKKGDFEKGFKSATKESLDQF EKDFKKKFEKNSAALDSIYPMPLLLVKSLLTHSALCRRHLSLGRGE*" /label="yhcO CDS" gene 913937..914905 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /label="yhcO gene" downshifts 914781 /Source="Nicolas_upshifts" /id="D473" /incds=1 /nref=28 /ntot=62 /MaxReadThrough="1.51621" /MaxDrop="5.75619" /score="6.21571271" /energy="-16.1" /TU="NA" /idTUdmin="U717" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(914837..915490) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_388799.1" /db_xref="EnsemblGenomes-Gn:BSU09180" /db_xref="EnsemblGenomes-Tr:CAB12746" /db_xref="GOA:P54601" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG11595" /db_xref="UniProtKB/Swiss-Prot:P54601" /translation="MDQFNQQQQSQMNKGIPGKPHKNHGGHEMFDMHEVLSGTLTVLD QFMMLRQFCKDQELLNILDRQHQFITSQYNITAECFKTGSEPSQKTATYMMKEDNQTV YGMQPSQPKKPVQSMNDIDDSIISRQMLCAIKAQASMLTMASLEMTNPAVRRVLSAQI QEYVEMAFEIFLYQNKHGYYQVPQLDAQDMEQLRNSFAPAQGQMPPTQGGMGQQGLH* " /label="yhcQ CDS" gene complement(914837..915490) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /label="yhcQ gene" downshifts complement(914854) /Source="Nicolas_upshifts" /id="D474" /incds=0 /nref=15 /ntot=57 /MaxReadThrough="4.13099" /MaxDrop="4.95733" /score="8.67086892" /energy="-12.9" /TU="U718" /idTUdmin="U718" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(915521..915532) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(915523) /Source="Nicolas_upshifts" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(915547..915553) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 915562..915570 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 915573..919226 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15292138, 21800427, 22020651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292138, 21800427, 22020651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non specific extracellular Ca2+-dependent endonuclease cleaving RNA and DNA" /protein_id="NP_388800.1" /db_xref="EnsemblGenomes-Gn:BSU09190" /db_xref="EnsemblGenomes-Tr:CAB12747" /db_xref="GOA:P54602" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR019948" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR035437" /db_xref="InterPro:IPR035451" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG11596" /db_xref="UniProtKB/Swiss-Prot:P54602" /translation="MLSVEMISRQNRCHYVYKGGNMMRRILHIVLITALMFLNVMYTF EAVKAAEPQQPISIEKAIQQKEGQALVEGYAVGQAVSPQHYKLTSPFSNDYNVALADR KNKTSPEHILPVQIPSAFRSQFGLQTNPLLLGKKITVQGKLENYFNTTGLKNVQSMNV TDDTKTPPAEQQVTINEARGRLNEEVTIKGIITADQNAIGGGKLSTFLQDETGGINIY SPSPEQFPELKEGMDVTVTGKITSYQGLKEIVPNSSGIKINQSNQSLPAPKHLTINEL INGSLGDQYEGRLVKLTAFVSSIPSSPAGGGYNVTMIDDDHHAMTLRVMNETGVINEL DEGKWYEFTGVLSRYQTFQLLPRKSADLKLLEEQPAPPSAEGEYEGIVDRVVDGDTIH LKSPVLGTTKIRFVNVDAPETYHTPKNDADENQLRFGKKASDYLKTVLSPGDKITVKV GSEAKDSYGRLLGQVITESGSNVNLELVKNGYAPTYFIWPVDNEEDYQQFQAAVAAAK KDQKGIWNENDPLMEMPFEFRAREQGKGLTRYVGDSSNKTYVQPADWKKIAVENRIFF ASASEAESAGYKKRQTAPQEHVPLRILSMNDLHGKIDQQYELDLDGNGTVDGTFGRMD YAAAYLKEKKAEKKNSLIVHAGDMIGGSSPVSSLLQDEPTVELMEDIGFDVGTVGNHE FDEGTDELLRILNGGDHPKGTSGYDGQNFPLVCANCKMKSTGEPFLPAYDIINVEGVP VAFIGVVTQSAAGMVMPEGIKNIEFTDEATAVNKAAEELKKKGVKAIAVLAHMSAEQN GNAITGESADLANKTDSEIDVIFAAHNHQVVNGEVNGKLIVQAFEYGKAIGVVDVEID KTTKDIVKKSAEIVYVDQSKIEPDVSASAILKKYETIAEPIISEVVGEAAVDMEGGYS NDGDTPLGNLIADGMRAAMKTDFALMNGGGIREALKKGPITWGDLYNIQPFGNVLTKL EIKGKDLREIINAQISPVFGPDYSISGFTYTWDKETGKAVDMKMADGTEIQPDATYTL TVNNFMATATGAKYQPIGLLGKNPVTGPEDLEATVEYVKSFDEPIAYTKEGRIKLAEA SDIEDPVTEDPITEEPGDDPGTEDPIKEDPRPGEDLPDIKETPGTAPVHQLPPSAISR FNEIPINNTKTADTANSISTLPLQTETAESGSDHQLPDTSAGYYNFMVIGAAVTLSGT YLYVRRKRSASRT*" /label="mncR CDS" gene 915573..919226 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /label="mncR gene" promotor_-10 915581..915599 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 915596 /Source="Nicolas_upshifts" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="upshifts" CDS 919223..919819 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /EC_number="3.4.22.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12823805, 21800427, 22020651, 25038633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12823805, 21800427, 22020651, 25038633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sortase A" /protein_id="NP_388801.1" /db_xref="EnsemblGenomes-Gn:BSU09200" /db_xref="EnsemblGenomes-Tr:CAB12748" /db_xref="GOA:P54603" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG11597" /db_xref="UniProtKB/Swiss-Prot:P54603" /translation="MKKVIPLFIIAAGLVIAGYGGFKLIDTNTKTEQTLKEAKLAAKK PQEASGTKNSTDQAKNKASFKPETGQASGILEIPKINAELPIVEGTDADDLEKGVGHY KDSYYPDENGQIVLSGHRDTVFRRTGELEKGDQLRLLLSYGEFTYEIVKTKIVDKDDT SIITLQHEKEELILTTCYPFSYVGNAPKRYIIYGKRVT*" /label="srtA CDS" gene 919223..919819 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /label="srtA gene" downshifts 919798 /Source="Nicolas_upshifts" /id="D475" /incds=0 /nref=142 /ntot=248 /MaxReadThrough="0.9984" /MaxDrop="5.92245" /score="-4.06268332" /energy="-8.8" /TU="NA" /idTUdmin="U719" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(919849..920757) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /EC_number="5.4.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9814761, 15044829; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA pseudouridine synthase" /protein_id="NP_388802.2" /db_xref="EnsemblGenomes-Gn:BSU09210" /db_xref="EnsemblGenomes-Tr:CAB12749" /db_xref="GOA:P54604" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11598" /db_xref="UniProtKB/Swiss-Prot:P54604" /translation="MNQKGRGLEILINEKQDGQWLFSVLKTALKASKPVIQDWMSHQQ IKVNHESVLNNMIVKKGDRVFIDLQESEASSVIPEYGELDILFEDNHMLIINKPAGIA THPNEDGQTGTLANLIAYHYQINGETCKVRHVHRLDQDTSGAIVFAKHRLAHAILDQQ LEKKTLKRTYTAIAEGKLRTKKGTINSPIGRDRSHPTRRRVSPGGQTAVTHFKVMASN AKERLSLVELELETGRTHQIRVHLASLGHPLTGDSLYGGGSKLLNRQALHANKVQAVH PITDELIVAEAPFPADMKNLCRTYFS*" /label="yhcT CDS" gene complement(919849..920757) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /label="yhcT gene" promotor_-35 920813..920821 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(920814..920825) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(920820) /Source="Nicolas_upshifts" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(920822..921308) /Source="Nicolas_S_feature" /locus_tag="new_996597_997083_c" /HighExp="S8, dia15, Diami, H2O2, G180, G150, dia5, Paraq, Oxctl, S7" /AntisenseName="yhcU" /AntisenseCor="0.69394173601478304" /AntisenseRegPval="-39.200000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S319" upshifts 920832 /Source="Nicolas_upshifts" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 920835..920854 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(920839..920845) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 920868..921263 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388803.2" /db_xref="EnsemblGenomes-Gn:BSU09220" /db_xref="EnsemblGenomes-Tr:CAB12750" /db_xref="InterPro:IPR020355" /db_xref="SubtiList:BG11599" /db_xref="UniProtKB/Swiss-Prot:P54605" /translation="MARKVIDVRIVNAATAEQESFIKELSMELIHDVFPLYFSELDIQ RFKKKGVLSLNNHYYQGTLKEAFQIMACLQMIHIILTKPSPHSDLSDQAIFEKNSKML NDFGIYFPFAFSDFQKKTNKAFFGQRRLI*" /label="yhcU CDS" gene 920868..921263 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /label="yhcU gene" misc_feature complement(921294..921313) /Source="Nicolas_upshift_promotors" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(921308) /Source="Nicolas_upshifts" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 921348..921354 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 921363 /Source="Nicolas_upshifts" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 921368..921379 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(921378..921392) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(921392) /Source="Nicolas_upshifts" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(921400..921404) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 921400..921822 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CBS containing enzyme (sporulation-/ germination-related)" /protein_id="NP_388804.1" /db_xref="EnsemblGenomes-Gn:BSU09230" /db_xref="EnsemblGenomes-Tr:CAB12751" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG11600" /db_xref="UniProtKB/Swiss-Prot:P54606" /translation="MSSVKDTMTTQVATVSPNQTIQEAASLMKQHNVGAIPVVEQGVL KGMLTDRDIALRTTAQGRDGQTPVSEVMSTELVSGNPNMSLEDASQLMAQHQIRRLPI VDQNNLVGIVALGDLAVNQMSNESAGSALTNISHQNIH*" /label="yhcV CDS" gene 921400..921822 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /label="yhcV gene" promotor_no_box complement(921726..921826) /Source="Nicolas_upshift_promotors" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(921766) /Source="Nicolas_upshifts" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 921800 /Source="Nicolas_upshifts" /id="D476" /incds=0 /nref=50 /ntot=61 /MaxReadThrough="2.62549" /MaxDrop="7.03747" /score="-2.59023198" /energy="-12.1" /TU="NA" /idTUdmin="U723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(921832) /Source="Nicolas_upshifts" /id="D477" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="0.0992700000000006" /MaxDrop="3.96142" /score="-9.32793172" /energy="-9.1" /TU="NA" /idTUdmin="U724" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" promotor_-35 921872..921879 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 921893..921912 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 921901 /Source="Nicolas_upshifts" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="upshifts" CDS 921949..922611 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /EC_number="3.1.3.18" /EC_number="3.1.3.68" /EC_number="3.1.3.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16990279, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphoglycolate phosphatase / glycerol-3-phosphate phosphatase / 2-deoxyglucose-6-phosphatase" /protein_id="NP_388805.1" /db_xref="EnsemblGenomes-Gn:BSU09240" /db_xref="EnsemblGenomes-Tr:CAB12752" /db_xref="GOA:P54607" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11601" /db_xref="UniProtKB/Swiss-Prot:P54607" /translation="MIKALIFDFDGLILDTETHEYEVLQEIFEEHGSVLPLSVWGKVI GTAAGFRPFEYLEEQIGKKLNHEELTQLRRERFAKRMESEKARPGVEAYLNAAKDLGL KIGLASSSDYKWVSGHLKQIGLFDDFEVIQTADDVEEVKPNPELYLLAAKNLGVSPAE CLAFEDSVNGSIAAKRAGMKCVIVPNKVTGTLMFEDYDHRLESMAEMELALLLDHLNS QN*" /label="glpW CDS" gene 921949..922611 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /label="glpW gene" CDS 922627..924168 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /EC_number="3.5.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26337367, 26808445, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388806.2" /db_xref="EnsemblGenomes-Gn:BSU09250" /db_xref="EnsemblGenomes-Tr:CAB12753" /db_xref="GOA:P54608" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR001110" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG11602" /db_xref="UniProtKB/Swiss-Prot:P54608" /translation="MSEKLDLTRFEKKMVIRNIEEKDIDKIIDLQKDCFPGMEPWKRE HLISHLEHFPEGQFCAEFEGEIIGSCSSLLINFDEYDDRHTWQDITDDGYITNHNPDG LNMYGIEVMVHPKYRRMKIGHRLYEARKDLARRLNLKSIIIGGRIPNYHKYAEEMTAR EYVEQVTRHQIYDPVLSFQLMNGFTLMRINPNYLPDDTASIKYATLMEWNNVDYLPQQ TKRYYKSAFPVRICVIQYEMKKIYSFEEFANQVEYYVDVASDARSDFAVFPEIFTTQL MSFLEERSPSLAVQRITEYTEDYISLFTDLAVKYNVNIIGGSHFVEEEGKIYNIAYLF RRDGTIEKQYKLHITPNERKWWGISAGDQVRVFDTDCGKIAIQICYDIEFPELARIAA DKGAKIIFTPFCTEDRQGYLRVRYCSQARAVENQIYTVISGTVGNLPQTENMDIQYAQ SGIFAPSDFEFARDGIVGETNPNIEMVVIGDVDLEILRRQRQNGTVRQLKDRRRDIYH IQYKK*" /label="yhcX CDS" gene 922627..924168 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /label="yhcX gene" downshifts 924151 /Source="Nicolas_upshifts" /id="D478" /incds=0 /nref=57 /ntot=238 /MaxReadThrough="4.24486" /MaxDrop="5.06754" /score="24.7413026" /energy="-10.5" /TU="U726" /idTUdmin="U726" /TUdmin="-224" /isTUend="FALSE" /label="downshifts" CDS 924252..924443 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52585.1" /translation="MYSGCALWSFCIFAISYIIQKTARLHIAIAMAVQVVSSATFIST MLSIVTLPVLLWKLHPLSS*" /label="yhzG CDS" gene 924252..924443 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /pseudo /label="yhzG gene" promotor_-35 924474..924481 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-35" promotor_-10 924496..924515 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-10" S_feature 924507..924588 /Source="Nicolas_S_feature" /locus_tag="new_1000282_1000363" /HighExp="M40t90, M0t90, T0.30H, LBGstat, BC, Lbstat, M9-stat, Lbtran, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S320" upshifts 924507 /Source="Nicolas_upshifts" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="upshifts" CDS 924589..925941 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11082195, 23610425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase" /protein_id="NP_388807.2" /db_xref="EnsemblGenomes-Gn:BSU09260" /db_xref="EnsemblGenomes-Tr:CAB12754" /db_xref="GOA:P33189" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10184" /db_xref="UniProtKB/Swiss-Prot:P33189" /translation="MEMMGMENIQQNQGLKQKDEQFVWHAMKGAHQADSLIAQKAEGA WVTDTDGRRYLDAMSGLWCVNIGYGRKELAEAAYEQLKELPYYPLTQSHAPAIQLAEK LNEWLGGDYVIFFSNSGSEANETAFKIARQYHLQNGDHSRYKFISRYRAYHGNTLGAL SATGQAQRKYKYEPLSQGFLHAAPPDIYRNPDDADTLESANEIDRIMTWELSETIAGV IMEPIITGGGILMPPDGYMKKVEDICRRHGALLICDEVICGFGRTGEPFGFMHYGVKP DIITMAKGITSAYLPLSATAVKRDIFEAYQGEAPYDRFRHVNTFGGSPAACALALKNL QIMEDEQLIQRSRDLGAKLLGELQALREHPAVGDVRGKGLLIGIELVKDKLTKEPADA AKVNQVVAACKEKGLIIGKNGDTVAGYNNVIQLAPPFCLTEEDLSFIVKTVKESFQTI *" /label="yhxA CDS" gene 924589..925941 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /label="yhxA gene" CDS 925969..926547 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11929549, 23610425, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 23610425, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate responding transcriptionantiterminator" /protein_id="NP_388808.1" /db_xref="EnsemblGenomes-Gn:BSU09270" /db_xref="EnsemblGenomes-Tr:CAB12755" /db_xref="GOA:P30300" /db_xref="InterPro:IPR006699" /db_xref="InterPro:IPR035928" /db_xref="SubtiList:BG10185" /db_xref="UniProtKB/Swiss-Prot:P30300" /translation="MMSFHNQPILPAIRNMKQFDEFLNSSFSYGVILDIHLGQLKGVI KEAQKHGKNMMVHVDLIQGIKHDEYGAEFICQDIKPAGIISTRSNVIAKAKQKKIYAI QRLFLLDTSAMEKSMEFIGKHKPDFIEVLPGIVPSLIQEIKEKTGIPIFAGGFIRTEE DVEQALKAGAVAVTTSNTKLWKKYENFLTESD*" /label="glpP CDS" gene 925969..926547 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /label="glpP gene" promotor_-35 926542..926549 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 926564..926583 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 926575 /Source="Nicolas_upshifts" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" downshifts 926590 /Source="Nicolas_upshifts" /id="D479" /incds=0 /nref=3 /ntot=39 /MaxReadThrough="8.20986" /MaxDrop="2.99328" /score="6.07464219" /energy="-10" /TU="U727,U728" /idTUdmin="U726" /TUdmin=2215 /isTUend="FALSE" /label="downshifts" S_feature 926635..926725 /Source="Nicolas_S_feature" /locus_tag="new_1002410_1002500" /HighExp="Diami, T0.30H, G150, Oxctl, Gly, Paraq, dia5, BC, B60, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S321" CDS 926726..927550 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycerol permease" /protein_id="NP_388809.1" /db_xref="EnsemblGenomes-Gn:BSU09280" /db_xref="EnsemblGenomes-Tr:CAB12756" /db_xref="GOA:P18156" /db_xref="InterPro:IPR000425" /db_xref="InterPro:IPR022357" /db_xref="InterPro:IPR023271" /db_xref="SubtiList:BG10186" /db_xref="UniProtKB/Swiss-Prot:P18156" /translation="MTAFWGEVIGTMLLIIFGAGVCAGVNLKKSLSFQSGWIVVVFGW GLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVYIAAQMIGAIIGAVIIYL HYLPHWKSTDDPAAKLGVFSTGPSIPHTFANVLSEVIGTFVLVLGILAIGANQFTEGL NPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFLPIPGKGSSNWKYAWVPVVG PILGGSFGGVFYNAAFKGHITSSFWIVSVILVVVLLGLYVYTKSHSAKTLSNSKYI*" /label="glpF CDS" gene 926726..927550 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /label="glpF gene" CDS 927569..929059 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /EC_number="2.7.1.30" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9972264, 10920256, 11929549, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol kinase (sn-glycerol-3-phosphate generating)" /protein_id="NP_388810.2" /db_xref="EnsemblGenomes-Gn:BSU09290" /db_xref="EnsemblGenomes-Tr:CAB12757" /db_xref="GOA:P18157" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005999" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10187" /db_xref="UniProtKB/Swiss-Prot:P18157" /translation="METYILSLDQGTTSSRAILFNKEGKIVHSAQKEFTQYFPHPGWV EHNANEIWGSVLAVIASVISESGISASQIAGIGITNQRETTVVWDKDTGSPVYNAIVW QSRQTSGICEELREKGYNDKFREKTGLLIDPYFSGTKVKWILDNVEGAREKAEKGELL FGTIDTWLIWKMSGGKAHVTDYSNASRTLMFNIYDLKWDDELLDILGVPKSMLPEVKP SSHVYAETVDYHFFGKNIPIAGAAGDQQSALFGQACFEEGMGKNTYGTGCFMLMNTGE KAIKSEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGLRMFQDSSLSESYAEK VDSTDGVYVVPAFVGLGTPYWDSDVRGSVFGLTRGTTKEHFIRATLESLAYQTKDVLD AMEADSNISLKTLRVDGGAVKNNFLMQFQGDLLNVPVERPEINETTALGAAYLAGIAV GFWKDRSEIANQWNLDKRFEPELEEEKRNELYKGWQKAVKAAMAFK*" /label="glpK CDS" gene 927569..929059 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /label="glpK gene" promotor_-35 928370..928376 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 928391..928410 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-10" upshifts 928401 /Source="Nicolas_upshifts" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="upshifts" S_feature 929060..929148 /Source="Nicolas_S_feature" /locus_tag="new_1004835_1004923" /HighExp="Sw, Etha, Salt, G150, Gly, Diami, T0.30H, B60, BC, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S322" downshifts 929105 /Source="Nicolas_upshifts" /id="D480" /incds=0 /nref=34 /ntot=91 /MaxReadThrough="7.63856" /MaxDrop="5.2045" /score="21.1943866" /energy="-28.7" /TU="U728,U729" /idTUdmin="U727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 929111..929211 /Source="Nicolas_upshift_promotors" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 929171 /Source="Nicolas_upshifts" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" CDS 929200..930867 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /EC_number="1.1.3.21" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2127799, 8825777, 9595668, 10633102, 18946204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2127799, 8825777, 9595668, 10633102, 18946204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate oxidase (FAD-dependent)" /protein_id="NP_388811.2" /db_xref="EnsemblGenomes-Gn:BSU09300" /db_xref="EnsemblGenomes-Tr:CAB12758" /db_xref="GOA:P18158" /db_xref="InterPro:IPR000447" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR031656" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10188" /db_xref="UniProtKB/Swiss-Prot:P18158" /translation="MMNHQFSSLERDRMLTDMTKKTYDLFIIGGGITGAGTALDAASR GMKVALSEMQDFAAGTSSRSTKLVHGGLRYLKQFEVKMVAEVGKERAIVYENGPHVTT PEWMLLPFHKGGTFGSFTTSIGLRVYDFLAGVKKSERRSMLSAKETLQKEPLVKKDGL KGGGYYVEYRTDDARLTIEVMKEAVKFGAEPVNYSKVKELLYEKGKAVGVLIEDVLTK KEYKVYAKKIVNATGPWVDQLREKDHSKNGKHLQHTKGIHLVFDQSVFPLKQAVYFDT PDGRMVFAIPREGKTYVGTTDTVYKEALEHPRMTTEDRDYVIKSINYMFPELNITAND IESSWAGLRPLIHEEGKDPSEISRKDEIWTSDSGLITIAGGKLTGYRKMAEHIVDLVR DRLKEEGEKDFGPCKTKNMPISGGHVGGSKNLMSFVTAKTKEGIAAGLSEKDAKQLAI RYGSNVDRVFDRVEALKDEAAKRNIPVHILAEAEYSIEEEMTATPADFFVRRTGRLFF DINWVRTYKDAVIDFMSERFQWDEQAKNKHTENLNKLLHDAVVPLEQ*" /label="glpD CDS" gene 929200..930867 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /label="glpD gene" promotor_-35 930629..930634 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 930649..930667 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-10" upshifts 930658 /Source="Nicolas_upshifts" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="upshifts" promotor_-35 930712..930718 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 930733 /Source="Nicolas_upshifts" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 930734..930752 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 930835 /Source="Nicolas_upshifts" /id="D481" /incds=0 /nref=13 /ntot=60 /MaxReadThrough="6.57605" /MaxDrop="4.31183" /score="11.5542287" /energy="-11.4" /TU="U728,U729,U730,U731,U732" /idTUdmin="U729" /TUdmin="-118" /isTUend="FALSE" /label="downshifts" S_feature 930880..930953 /Source="Nicolas_S_feature" /locus_tag="new_1006655_1006728" /HighExp="G150, Etha, Oxctl, H2O2, Gly, Diami, Paraq, Salt, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF, Sig-, SigB, SigA" /TUshortPSig="1, 0.995, 0.155, 1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S323" promotor_-35 930935..930942 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 930955 /Source="Nicolas_upshifts" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 930956..930975 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 930999..932744 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /EC_number="5.4.2.2" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15640167, 17662947, 24097947, 26735940, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15640167, 17662947, 24097947, 26735940, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-phosphoglucomutase" /protein_id="NP_388812.2" /db_xref="EnsemblGenomes-Gn:BSU09310" /db_xref="EnsemblGenomes-Tr:CAB12759" /db_xref="GOA:P18159" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG10189" /db_xref="UniProtKB/Swiss-Prot:P18159" /translation="MTWRKSYERWKQTEHLDLELKERLIELEGDEQALEDCFYKDLEF GTGGMRGEIGAGTNRMNIYTVRKASAGFAAYISKQGEEAKKRGVVIAYDSRHKSPEFA MEAAKTLATQGIQTYVFDELRPTPELSFAVRQLNAYGGIVVTASHNPPEYNGYKVYGD DGGQLPPKEADIVIEQVNAIENELTITVDEENKLKEKGLIKIIGEDIDKVYTEKLTSI SVHPELSEEVDVKVVFTPLHGTANKPVRRGLEALGYKNVTVVKEQELPDSNFSTVTSP NPEEHAAFEYAIKLGEEQNADILIATDPDADRLGIAVKNDQGKYTVLTGNQTGALLLH YLLSEKKKQGILPDNGVVLKTIVTSEIGRAVASSFGLDTIDTLTGFKFIGEKIKEYEA SGQYTFQFGYEESYGYLIGDFARDKDAIQAALLAVEVCAFYKKQGMSLYEALINLFNE YGFYREGLKSLTLKGKQGAEQIEAILASFRQNPPQKMAGKQVVTAEDYAVSKRTLLTE SKEEAIDLPKSNVLKYFLEDGSWFCLRPSGTEPKVKFYFAVKGSSLEDSEKRLAVLSE DVMKTVDEIVESTAK*" /label="pgcA CDS" gene 930999..932744 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /label="pgcA gene" downshifts 932733 /Source="Nicolas_upshifts" /id="D482" /incds=0 /nref=227 /ntot=264 /MaxReadThrough="4.80136" /MaxDrop="5.89896" /score="26.7163878" /energy="-13" /TU="U732,U733" /idTUdmin="U728" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" S_feature 932778..932847 /Source="Nicolas_S_feature" /locus_tag="new_1008553_1008622" /HighExp="Etha, H2O2, B36, dia15, Paraq, G150, LoTm, S8, Oxctl, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S324" misc_feature 932849..932868 /Source="Nicolas_upshift_promotors" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 932849 /Source="Nicolas_upshifts" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" CDS 932893..934032 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YhcZ]" /protein_id="NP_388813.1" /db_xref="EnsemblGenomes-Gn:BSU09320" /db_xref="EnsemblGenomes-Tr:CAB12760" /db_xref="GOA:O07527" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13005" /db_xref="UniProtKB/Swiss-Prot:O07527" /translation="MSKTRMEKLKTLKTIAETLNQGHDIKATLDEVLKELLSLTNLQS GWIFLIEEDGSYTLAADAYLPPALSRKEKVLMCEGECYCLTKFNNGGLRKAANIMNCK RIESAENLHCFDTEGITHHATVPLEDGDRRFGLLNVAAAGKTMFDEEELHLLESVAFQ IGTAIQRMRLSEYQQKNALLMERNRLAQELHDSVNQMLFSVSLTAKAAKTLTKDENLQ QMIDFIQNLSQDALAEMKALIWQLRPGGLEKGLAEAIKSYGALIGLKIIFTQKGCPVL TDEQEHMLWRVVQEALNNCKKHAGTDTAYVSLTASLCHAELDIIDHGAGFRYEAHAGL PSLGIKGMKERAEKAGAKFWIESALGTGTKLSIRLPLKSRKGGAV*" /label="yhcY CDS" gene 932893..934032 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /label="yhcY gene" CDS 934029..934673 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YhcY]" /protein_id="NP_388814.1" /db_xref="EnsemblGenomes-Gn:BSU09330" /db_xref="EnsemblGenomes-Tr:CAB12761" /db_xref="GOA:O07528" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13006" /db_xref="UniProtKB/Swiss-Prot:O07528" /translation="MKIVIADDHHVVRKGLRFFFATQDDIEVVGEAATGLEALRVIEE TKPDLVLMDLSMPEMDGIQAIKKAIQQFPDTNIIVLTSYSDQEHVIPALQAGAKAYQL KDTEPEELVKTRQVHGGEYKLSTAIMPHVLTHMKNQHDPEKEKYYQLTRREKDVLTEI ANGKSNKEIAAALFISEKTVKTHVSNLLAKLEVADRTQAALFAVKYNLNGEISK*" /label="yhcZ CDS" gene 934029..934673 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /label="yhcZ gene" CDS 934670..935194 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /EC_number="1.7.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15184374, 16816187, 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidoreductase, NAD(P)H-FMN and ferric iron reductase (azoreductase)" /protein_id="NP_388815.1" /db_xref="EnsemblGenomes-Gn:BSU09340" /db_xref="EnsemblGenomes-Tr:CAB12762" /db_xref="GOA:O07529" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1NNI" /db_xref="PDB:2GSW" /db_xref="PDB:3GFQ" /db_xref="PDB:3GFR" /db_xref="PDB:3GFS" /db_xref="SubtiList:BG13007" /db_xref="UniProtKB/Swiss-Prot:O07529" /translation="MNMLVINGTPRKHGRTRIAASYIAALYHTDLIDLSEFVLPVFNG EAEQSELLKVQELKQRVTKADAIVLLSPEYHSGMSGALKNALDFLSSEQFKYKPVALL AVAGGGKGGINALNNMRTVMRGVYANVIPKQLVLDPVHIDVENATVAENIKESIKELV EELSMFAKAGNPGV*" /label="azr CDS" gene 934670..935194 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /label="azr gene" downshifts 935159 /Source="Nicolas_upshifts" /id="D483" /incds=0 /nref=72 /ntot=215 /MaxReadThrough="2.90096" /MaxDrop="4.78561" /score="27.1269177" /energy="-17.2" /TU="NA" /idTUdmin="U734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(935209..935451) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388816.1" /db_xref="EnsemblGenomes-Gn:BSU09350" /db_xref="EnsemblGenomes-Tr:CAB12763" /db_xref="InterPro:IPR025431" /db_xref="SubtiList:BG13008" /db_xref="UniProtKB/Swiss-Prot:O07530" /translation="MDYADYDKALYYTHRSQWDNLLILMVRTEDDLLSKRIEHFLHAY HFEQDYAVLEKMLYSLLRYIDHATELTYEDQIALLT*" /label="yhdB CDS" gene complement(935209..935451) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /label="yhdB gene" downshifts complement(935230) /Source="Nicolas_upshifts" /id="D484" /incds=0 /nref=39 /ntot=84 /MaxReadThrough="-0.0235599999999998" /MaxDrop="7.78706" /score="12.0066876" /energy="-17.2" /TU="NA" /idTUdmin="U735" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(935487..935498) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(935498) /Source="Nicolas_upshifts" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(935512..935519) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 935586..935592 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 935606..935617 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 935616 /Source="Nicolas_upshifts" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="upshifts" CDS 935652..935975 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388817.1" /db_xref="EnsemblGenomes-Gn:BSU09360" /db_xref="EnsemblGenomes-Tr:CAB12764" /db_xref="InterPro:IPR024987" /db_xref="SubtiList:BG13009" /db_xref="UniProtKB/Swiss-Prot:O07531" /translation="MKSLPYTIALLFCGLIIVSMAAKGHSTDTDESVQKWEQLAWSKI QDEYKGASFSDYAYMGRTEVNDQQTKDVFRVTVRQKDDTFSVRAEVYFHPVTNHMISI NVFRL*" /label="yhdC CDS" gene 935652..935975 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /label="yhdC gene" S_feature 935976..937842 /Source="Nicolas_S_feature" /locus_tag="new_1011751_1013617" /HighExp="S8, S5, S7, S6, S4, C30, Sw, ferm, S3, BC" /AntisenseName="lytF" /AntisenseCor="-0.65564579825076796" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S325" CDS complement(936017..937483) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10206711, 14594841, 18761694, 18761696, 23091053, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10206711, 14594841, 18761694, 18761696, 23091053, 25288647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamate-meso-diaminopimelate muropeptidase (major autolysin, vegetative)" /protein_id="NP_388818.2" /db_xref="EnsemblGenomes-Gn:BSU09370" /db_xref="EnsemblGenomes-Tr:CAB12776" /db_xref="GOA:O07532" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13010" /db_xref="UniProtKB/Swiss-Prot:O07532" /translation="MKKKLAAGLTASAIVGTTLVVTPAEAATIKVKSGDSLWKLAQTY NTSVAALTSANHLSTTVLSIGQTLTIPGSKSSTSSSTSSSTTKKSGSSVYTVKSGDSL WLIANEFKMTVQELKKLNGLSSDLIRAGQKLKVSGTVSSSSSSSKKSNSNKSSSSSSK SSSNKSSSSSSSTGTYKVQLGDSLWKIANKVNMSIAELKVLNNLKSDTIYVNQVLKTK SSGSDTSSKDNSSKSNQTSATTKYTVKSGDSLWKIANNYNLTVQQIRNINNLKSDVLY VGQVLKLTGKASSGSSSSSSSSSNASSGTTTTYTVKSGDSLWVIAQKFNVTAQQIREK NNLKTDVLQVGQKLVISGKASSSSSSGSSNTTSSTSAKINTMISAAKAQLGVPYRWGG TTPSGFDCSGFIYYVLNKVTSVSRLTAAGYWNTMKSVSQPAVGDFVFFSTYKAGPSHV GIYLGNGEFINANDSGVVISNMNNSYWKQRYLGAKRYF*" /label="lytF CDS" gene complement(936017..937483) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /label="lytF gene" downshifts complement(936029) /Source="Nicolas_upshifts" /id="D485" /incds=0 /nref=121 /ntot=216 /MaxReadThrough="2.34529" /MaxDrop="4.33563" /score="24.6732339" /energy="-14.2" /TU="NA" /idTUdmin="U737" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(936116) /Source="Nicolas_upshifts" /id="D486" /incds=1 /nref=1 /ntot=87 /MaxReadThrough="5.73069" /MaxDrop="2.6306" /score="24.6732339" /energy="-14.2" /TU="U737" /idTUdmin="U737" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(937523..937541) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(937535) /Source="Nicolas_upshifts" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(937555..937562) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(937636..938076) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033; Product type r: regulator" /codon_start=1 /transl_table=11 /product="NO-dependent activator of the ResDE regulon (Fe-S NO binding site)" /protein_id="NP_388819.1" /db_xref="EnsemblGenomes-Gn:BSU09380" /db_xref="EnsemblGenomes-Tr:CAB12777" /db_xref="GOA:O07573" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13011" /db_xref="UniProtKB/Swiss-Prot:O07573" /translation="MKLTNYTDYSLRVLIFLAAERPGELSNIKQIAETYSISKNHLMK VIYRLGQLGYVETIRGRGGGIRLGMDPEDINIGEVVRKTEDDFNIVECFDANKNLCVI SPVCGLKHVLNEALLAYLAVLDKYTLRDLVKNKEDIMKLLKMKE*" /label="nsrR CDS" gene complement(937636..938076) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /label="nsrR gene" downshifts complement(937666) /Source="Nicolas_upshifts" /id="D487" /incds=0 /nref=205 /ntot=265 /MaxReadThrough="3.11158" /MaxDrop="6.87147" /score="5.96186156" /energy="-7.8" /TU="U739" /idTUdmin="U740" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" promotor_-35 938064..938070 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 938084..938095 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 938086..938196 /Source="Nicolas_S_feature" /locus_tag="new_1013861_1013971" /HighExp="S8, S7, S4, Sw, S5, S6, BC, B60, nit, Pyr" /AntisenseName="ygxB" /AntisenseCor="-0.211236686077168" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.904" /TUlongSig="NA" /TUlongPSig="NA" /label="S326" upshifts 938086 /Source="Nicolas_upshifts" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(938098..938117) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(938114) /Source="Nicolas_upshifts" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(938129..938135) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 938155 /Source="Nicolas_upshifts" /id="D488" /incds=0 /nref=10 /ntot=68 /MaxReadThrough="1.05981" /MaxDrop="6.25571" /score="22.5171081" /energy="-11.6" /TU="NA" /idTUdmin="U738" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(938183..939841) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388820.1" /db_xref="EnsemblGenomes-Gn:BSU09390" /db_xref="EnsemblGenomes-Tr:CAB12778" /db_xref="GOA:P37874" /db_xref="InterPro:IPR008910" /db_xref="SubtiList:BG10181" /db_xref="UniProtKB/Swiss-Prot:P37874" /translation="MYEPARQKMIVSLGQEKIPPAHSSVCLLDKWVNTHHTTKKERYQ LNVADVFSSYLSKLPNVIIALLVLLIGWAIAKIIEKAVYKGLSKTKIDDKLFAGKKPS RYSSEKVISKVVYFIALIIVFILFFNILHLTTVASPFVSMLSAIAAAIPSVLKAGLIL LLGWAAASVLSFLVKKIGMKLNTSDKLRKWNLVSEGKDIHQAVNTASQIVFYLVLLVF LPGVLSSLKISGISGPFTNMMESVLAFLPKLFAAALIVLIGWLVARLVRDIITNFLAS IGTERFAARMGLSIYLKDTSLSAVIGTIAYVLIMIPVVISALDQLDVAGISKPAVSML NTILNMLPNIMIAIVLVLAGIWAGKWVKSMVSGLLHRAGFDSVLGKMGMEAGTPAKLS LSQVVGMIAQIIVILLFTAEALQIVRLHFLVEIATGIIAYLPNVLVAVFILGLGLYAG ELVRKVLASMIKGQEFKSLAPIAKYTIIALAFFMALDQLGVAATIVNSAFIIVLSGFA LAFGLSFGLGGKDFASRYLSTFERKMQNTEIEKNRKNQNPPNDM*" /label="ygxB CDS" gene complement(938183..939841) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /label="ygxB gene" downshifts complement(938188) /Source="Nicolas_upshifts" /id="D489" /incds=0 /nref=6 /ntot=40 /MaxReadThrough="8.34865" /MaxDrop="5.55332" /score="-5.46969987" /energy="-14.5" /TU="U740" /idTUdmin="U740" /TUdmin="-532" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(939732..939750) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(939752) /Source="Nicolas_upshifts" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(939764..939770) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 939813..939818 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 939834..939852 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 939847 /Source="Nicolas_upshifts" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="upshifts" CDS 939872..941278 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8144469, 14680823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8144469, 14680823; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation, conserved in non sporulating bacteria" /protein_id="NP_388821.1" /db_xref="EnsemblGenomes-Gn:BSU09400" /db_xref="EnsemblGenomes-Tr:CAB12779" /db_xref="GOA:P37875" /db_xref="InterPro:IPR007390" /db_xref="SubtiList:BG10182" /db_xref="UniProtKB/Swiss-Prot:P37875" /translation="MNAEEKKGLQRAIEEITEIAKGFGLDFYPMRYEICPAEIIYTFG AYGMPTRFSHWSFGKQFHKMKLHYDLGLSKIYELVINSDPCYAFLLDSNSLIQNKLIV AHVLAHCDFFKNNCRFQNTKRDMVESMAATAERIKHYEQVHGIKEVESFLDAILSIQE HIDPSLVRPKLQWSVDDEEEEIEEAATPYDDLWSLDEKKPKKQVKKSKKPFPPRPEKD ILLFIEEHSRELEPWQRDILTMMREEMLYFWPQLETKIMNEGWASYWHQRIIRELDLT SDEAIEFAKLNAGVVQPSKTGINPYYLGLKIFEDIEKRYNNPTEEMKKMGVQPDSGRE KMFEVREIESDISFIRNYLTKELVMREDLYLFQKQGRDYKIIDKQWKSVRDQLVSMRV NGGFPYLTVNDGDYMKNNELYIKHWYEGIELDLKYLEKVLPYLFQLWGRSVHIESVLE DKEVMFSYDGKGVHRRYL*" /label="spoVR CDS" gene 939872..941278 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /label="spoVR gene" downshifts 941258 /Source="Nicolas_upshifts" /id="D490" /incds=0 /nref=43 /ntot=84 /MaxReadThrough="1.30719" /MaxDrop="6.74388" /score="26.4488835" /energy="-11.5" /TU="NA" /idTUdmin="U741" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(941308..942693) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8830275, 10913081, 12897025, 16491025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830275, 10913081, 12897025, 16491025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase A" /protein_id="NP_388822.2" /db_xref="EnsemblGenomes-Gn:BSU09410" /db_xref="EnsemblGenomes-Tr:CAB12780" /db_xref="GOA:P19406" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10183" /db_xref="UniProtKB/Swiss-Prot:P19406" /translation="MKKMSLFQNMKSKLLPIAAVSVLTAGIFAGAELQQTEKASAKKQ DKAEIRNVIVMIGDGMGTPYIRAYRSMKNNGDTPNNPKLTEFDRNLTGMMMTHPDDPD YNITDSAAAGTALATGVKTYNNAIGVDKNGKKVKSVLEEAKQQGKSTGLVATSEINHA TPAAYGAHNESRKNMDQIANSYMDDKIKGKHKIDVLLGGGKSYFNRKDRNLTKEFKQA GYSYVTTKQALKKNKDQQVLGLFADGGLAKALDRDSKTPSLKDMTVSAIDRLNQNKKG FFLMVEGSQIDWAAHDNDTVGAMSEVKDFEQAYKAAIEFAKKDKHTLVIATADHTTGG FTIGANGEKNWHAEPILSAKKTPEFMAKKISEGKPVKDVLARYANLKVTSEEIKSVEA AAQADKSKGASKAIIKIFNTRSNSGWTSTDHTGEEVPVYAYGPGKEKFRGLINNTDQA NIIFKILKTGK*" /label="phoA CDS" gene complement(941308..942693) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /label="phoA gene" downshifts complement(941334) /Source="Nicolas_upshifts" /id="D491" /incds=0 /nref=51 /ntot=178 /MaxReadThrough="1.90638" /MaxDrop="5.795" /score="22.2126775" /energy="-13.2" /TU="NA" /idTUdmin="U742" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(942720) /Source="Nicolas_upshifts" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(942722..944253) /Source="Nicolas_S_feature" /locus_tag="new_1018497_1020028_c" /HighExp="Etha, Salt, B60, Heat, M9-stat, T5.0H, T0.30H, T4.0H, T3.30H, T2.30H" /AntisenseName="lytE" /AntisenseCor="-0.65081062481616203" /AntisenseRegPval="-33.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="0.966, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S327" misc_feature complement(942730..942741) /Source="Nicolas_upshift_promotors" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 942849..942856 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 942869..942888 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 942875..943162 /Source="Nicolas_S_feature" /locus_tag="new_1018650_1018937" /HighExp="T-5.40H, Cold, LoTm, T-4.40H, UNK1, T5.0H, GM-0.1, T3.30H, S1, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S328" upshifts 942875 /Source="Nicolas_upshifts" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 943125..943128 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 943143..943162 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 943164 /Source="Nicolas_upshifts" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="upshifts" CDS 943223..944227 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 16950129, 9457885, 21541672, 22139507, 27002131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 16950129, 9457885, 21541672, 22139507, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cell wall dl-endopeptidase; phosphatase-associated protein (major autolysin)" /protein_id="NP_388823.2" /db_xref="EnsemblGenomes-Gn:BSU09420" /db_xref="EnsemblGenomes-Tr:CAB12781" /db_xref="GOA:P54421" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11406" /db_xref="UniProtKB/Swiss-Prot:P54421" /translation="MKKQIITATTAVVLGSTLFAGAASAQSIKVKKGDTLWDLSRKYD TTISKIKSENHLRSDIIYVGQTLSINGKSTSSKSSSSSSSSSTYKVKSGDSLWKISKK YGMTINELKKLNGLKSDLLRVGQVLKLKGSTSSSSSSSSKVSSSSTSTYKVKSGDSLS KIASKYGTTVSKLKSLNGLKSDVIYVNQVLKVKGTSTSSSKPASSSSSSSSKTSSTSL NVSKLVSDAKALVGTPYKWGGTTTSGFDCSGFIWYVLNKQTSVGRTSTAGYWSSMKSI ASPSVGDFVFFTTYKSGPSHMGIYIGNNSFIHAGSDGVQISSLNNSYWKPRYLGAKRF *" /label="lytE CDS" gene 943223..944227 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /label="lytE gene" downshifts 944089 /Source="Nicolas_upshifts" /id="D492" /incds=1 /nref=1 /ntot=117 /MaxReadThrough="6.89938" /MaxDrop="2.1687" /score="26.3320532" /energy="-9.8" /TU="U743,U744" /idTUdmin="U743" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 944219 /Source="Nicolas_upshifts" /id="D493" /incds=0 /nref=53 /ntot=190 /MaxReadThrough="3.64545" /MaxDrop="6.08377" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" upshifts complement(944253) /Source="Nicolas_upshifts" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(944260..944275) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 944265 /Source="Nicolas_upshifts" /id="D494" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="2.99" /MaxDrop="3.76174" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(944287..944296) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(944298..945173) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8045899, 10869065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045899, 10869065; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator CitR (LysR family)" /protein_id="NP_388824.2" /db_xref="EnsemblGenomes-Gn:BSU09430" /db_xref="EnsemblGenomes-Tr:CAB12782" /db_xref="GOA:P39127" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10853" /db_xref="UniProtKB/Swiss-Prot:P39127" /translation="MDFKWLHTFVTAAKYENFRKTAETLFLSQPTVTVHIKQLEKEIS CKLFERKGRQIQLTDEGRAYLPYALRLLDDYENSMAELHRVRQGYSQTLQLAVSPLIA DTVLPSVMKRYTAMNTETEMAVTIFESAEIASLIKAGEADIGLSCLKVQSSSLSCHCL YKDPVVLVAPPDKRFIEDNEIDAKEVLEQYLLLTHNHPDYWDDLLRQVRMTFPFVRTM KVTQTHITKRFIKEGLGVSFLPLSTVKRELAEKQMIRIPYQSVQLPYAGAYAIALYEN KKEKKFLDFLSHFHF*" /label="citR CDS" gene complement(944298..945173) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /label="citR gene" promotor_-35 945226..945227 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(945239..945258) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-10" promotor_-10 945244..945263 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(945245) /Source="Nicolas_upshifts" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="upshifts" upshifts 945254 /Source="Nicolas_upshifts" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(945273..945278) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-35" CDS 945282..946382 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:4211224, 8045898, 8045899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4211224, 8045898, 8045899; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase I" /protein_id="NP_388825.2" /db_xref="EnsemblGenomes-Gn:BSU09440" /db_xref="EnsemblGenomes-Tr:CAB12783" /db_xref="GOA:P39119" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR016143" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="PDB:2C6X" /db_xref="SubtiList:BG10854" /db_xref="UniProtKB/Swiss-Prot:P39119" /translation="MVHYGLKGITCVETSISHIDGEKGRLIYRGHHAKDIALNHSFEE AAYLILFGKLPSTEELQVFKDKLAAERNLPEHIERLIQSLPNNMDDMSVLRTVVSALG ENTYTFHPKTEEAIRLIAITPSIIAYRKRWTRGEQAIAPSSQYGHVENYYYMLTGEQP SEAKKKALETYMILATEHGMNASTFSARVTLSTESDLVSAVTAALGTMKGPLHGGAPS AVTKMLEDIGEKEHAEAYLKEKLEKGERLMGFGHRVYKTKDPRAEALRQKAEEVAGND RDLDLALHVEAEAIRLLEIYKPGRKLYTNVEFYAAAVMRAIDFDDELFTPTFSASRMV GWCAHVLEQAENNMIFRPSAQYTGAIPEEVLS*" /label="citA CDS" gene 945282..946382 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /label="citA gene" promotor_-35 946393..946399 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 946414..946432 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 946419 /Source="Nicolas_upshifts" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 946456..947325 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 18643936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)-dependent dehydrogenase" /protein_id="NP_388826.1" /db_xref="EnsemblGenomes-Gn:BSU09450" /db_xref="EnsemblGenomes-Tr:CAB12784" /db_xref="GOA:O07575" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13012" /db_xref="UniProtKB/Swiss-Prot:O07575" /translation="MNPMDRQTEGQEPQHQDRQPGIESKMNPLPLSEDEDYRGSGKLK GKVAIITGGDSGIGRAAAIAFAKEGADISILYLDEHSDAEETRKRIEKENVRCLLIPG DVGDENHCEQAVQQTVDHFGKLDILVNNAAEQHPQDSILNISTEQLEKTFRTNIFSMF HMTKKALPHLQEGCAIINTTSITAYEGDTALIDYSSTKGAIVSFTRSMAKSLADKGIR VNAVAPGPIWTPLIPATFPEEKVKQHGLDTPMGRPGQPVEHAGAYVLLASDESSYMTG QTIHVNGGRFIST*" /label="yhdF CDS" gene 946456..947325 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /label="yhdF gene" downshifts 947333 /Source="Nicolas_upshifts" /id="D495" /incds=0 /nref=27 /ntot=130 /MaxReadThrough="8.65426" /MaxDrop="6.48064" /score="18.1511963" /energy="-8.2" /TU="U748" /idTUdmin="U747" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 947410..947413 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 947425 /Source="Nicolas_upshifts" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 947428..947447 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 947473..947492 /Source="Nicolas_upshift_promotors" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 947478..947574 /Source="Nicolas_S_feature" /locus_tag="new_1023253_1023349" /HighExp="Etha, T2.30H, T-0.40H, T2.0H, T1.30H, S1, GM-0.2, T3.0H, T-1.40H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.27332800000000002" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.522, 0.998, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S329" upshifts 947478 /Source="Nicolas_upshifts" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" CDS 947575..948972 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16621821, 16850406, 21097623, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16621821, 16850406, 21097623, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid transporter or methylthioribose-degradation metabolite exporter" /protein_id="NP_388827.1" /db_xref="EnsemblGenomes-Gn:BSU09460" /db_xref="EnsemblGenomes-Tr:CAB12785" /db_xref="GOA:O07576" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004758" /db_xref="SubtiList:BG13013" /db_xref="UniProtKB/Swiss-Prot:O07576" /translation="MKGSVFRKKSIQDLIAATSGEKSLKRELGAFDLTLLGIGAIIGT GIFVLTGTGAVTAGPGLTISFVVAALACLFAALSYAEFASSVPVSGSVYTFTYATLGE LMAFIIGWDLILEYMLAVSAVSVGWSGYFQSFLSGLGIHLPVALTAAPGAVKGTFTLF NLPAFVIVMAITYLLYLGIKESKRVNNIMVILKILVVLLFIAVAAVYVKPHNWQPFMP MGFGGVFSAAALVFFAFIGFDAVSSAAEETKNPAKDLPKGIIFSLLVCTILYVTVSAI MTGVIPFAQFAGVDHPVSLVLQSAGQNWVAGIIDIGAVLGMTTVMLVMLYGQTRVMFA MSRDGLVPGSLSKVHPKHKTPYVATWFFGTMSALLGSLVPLDELAKLVNIGTLSAFVL ISVAVIVLRKKQPDLPRAFKCPGVPVIPGLAILFCLFLILNLGWVTIVRFLVWLLIGL VIYFLYSRKHSKLNQ*" /label="bcaP CDS" gene 947575..948972 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /label="bcaP gene" downshifts 948952 /Source="Nicolas_upshifts" /id="D496" /incds=0 /nref=116 /ntot=188 /MaxReadThrough="3.41176" /MaxDrop="5.29633" /score="5.08283681" /energy="-12.3" /TU="U748,U749" /idTUdmin="U750" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 949033..949037 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 949053..949072 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 949060 /Source="Nicolas_upshifts" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 949090..950445 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_388828.1" /db_xref="EnsemblGenomes-Gn:BSU09470" /db_xref="EnsemblGenomes-Tr:CAB12786" /db_xref="GOA:O07577" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13014" /db_xref="UniProtKB/Swiss-Prot:O07577" /translation="MSEQKPVQWASKIGFVMAAAGSAIGLGAIWKFPYVAGTNGGGAF FLIFVLFTILLGYPLLVGEFIFGRRNQTNAIDAYKKEAPRSAWFLTGWIGVAACFLVL SFYSVIGGWILLYIVKTASGSLSGLSQAQYGALFASIIQNPVQTLAAQLVFMALTVLV VARGVQKGIERVSAVMMPILFLLFILLVLRSLTLNGAMEGVKFLLVPHFGDLTPESIL FALGQAFFTLTLGVSVMVTYSSYLPKTQNIPRSAASIVLMNIIVTLLAGLAIFPAVFS FGFQPNEGPTLLFTVLPAVFEQLPFGTLFFIGFLVAFLFAALTSAFSMVEIIVATIGK GDEKKRKKLSWTSGLLIFLVGIPCCLSYGVLSDVHLFGKTFFDIADFTVSNVLMPSGA LLISLFIPLKISKSELLAEMRNGSNAGKAFFYTWFYLLRFIVPLAIIIVFLNLIGILS F*" /label="yhdH CDS" gene 949090..950445 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /label="yhdH gene" downshifts 950426 /Source="Nicolas_upshifts" /id="D497" /incds=0 /nref=184 /ntot=244 /MaxReadThrough="1.73756" /MaxDrop="6.09379" /score="40.1809389" /energy="-14.8" /TU="NA" /idTUdmin="U751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(950480..951889) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388829.1" /db_xref="EnsemblGenomes-Gn:BSU09480" /db_xref="EnsemblGenomes-Tr:CAB12787" /db_xref="GOA:O07578" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13015" /db_xref="UniProtKB/Swiss-Prot:O07578" /translation="MDITPFLDKKSKTPLYEQLYTFFKQEISHARITKGTRLPSKRRL SSLLDVSTATIERAYEQLTAEGYVKSKPKIGWFAAEVEPGFPTAPDHFQQSVQPGLHQ KNAPAIDFHQGSVDPTLFPFNAWRKSIVKSLDRYSGSFHTSGDPQGEYELRHMIARFV RLSRGVNCEPGQIIIGAGTTVLLQNLCLSLKPGTKIGFEEPGFHRSRRMFEANHMDVT PICSDAEGVLPDELYRQNPYLMYTTPSHQFPIGTIMTITRRQELLAWAAETNSFIIED DYDGEFRYSGHPIPSLQGLDPNGRVIYLGTFSKSLLPSLRLSFMIVPPELMEPIQNNV QLMKQTVSAHSQLALADFIETGEWQKHINRMRSLYRKKHAVLLEAIRSELGNTVEILG KNSGLHILLRLLFPASEEEAIQAAADHGVTLYPVSPSYIEQTPFTSVLIGYGGLSEED IRLGIQKLKTAWAPLISSY*" /label="yhdI CDS" gene complement(950480..951889) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /label="yhdI gene" promotor_-35 951938..951941 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 951956..951975 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 951958 /Source="Nicolas_upshifts" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(951960..951979) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(951972) /Source="Nicolas_upshifts" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(951995..951999) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 951999..952427 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388830.1" /db_xref="EnsemblGenomes-Gn:BSU09490" /db_xref="EnsemblGenomes-Tr:CAB12788" /db_xref="GOA:O07579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13016" /db_xref="UniProtKB/Swiss-Prot:O07579" /translation="MIHMKQLTSKEEWAESYPIMSELRTELDIETYLQRLEACVQKES YMLFALYENTAIRALCGALPRVSIHKGEHLWIADLVTTAPCRSKGYGKMLLDYASDWA RKAGLGFVSLSSGLQRKDAHRFYTDKMGFTIESYLFRKPV*" /label="yhdJ CDS" gene 951999..952427 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /label="yhdJ gene" downshifts 952406 /Source="Nicolas_upshifts" /id="D498" /incds=0 /nref=46 /ntot=213 /MaxReadThrough="1.42962" /MaxDrop="4.77191" /score="24.6412105" /energy="-12.1" /TU="NA" /idTUdmin="U752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(952458..952748) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388831.1" /db_xref="EnsemblGenomes-Gn:BSU09500" /db_xref="EnsemblGenomes-Tr:CAB12789" /db_xref="GOA:O07580" /db_xref="InterPro:IPR020496" /db_xref="SubtiList:BG13017" /db_xref="UniProtKB/Swiss-Prot:O07580" /translation="MELVRIFKEHNVFGWISVGTAVLSLLLLNLAIISNVTFYSYQML PFAMAAVPFGVVELFIKRGRTGPGLLGVILNLFVIICVYTIVSVDTNLQFGF*" /label="asiMB CDS" gene complement(952458..952748) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /label="asiMB gene" downshifts complement(952482) /Source="Nicolas_upshifts" /id="D499" /incds=0 /nref=44 /ntot=229 /MaxReadThrough="2.66153" /MaxDrop="4.72865" /score="26.7359231" /energy="-11.1" /TU="NA" /idTUdmin="U754" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(952736..953812) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388832.1" /db_xref="EnsemblGenomes-Gn:BSU09510" /db_xref="EnsemblGenomes-Tr:CAB12790" /db_xref="GOA:O07581" /db_xref="InterPro:IPR025672" /db_xref="InterPro:IPR029101" /db_xref="SubtiList:BG13018" /db_xref="UniProtKB/Swiss-Prot:O07581" /translation="MMNEEFKKRFDQYKNGEMSDQEMTAFEEELEKLEVYQELIDSEL EDDNDWDLSISPEKQKAILAYGKRKSYLRISVLAVISTLMILPLCTLGSYLYYGMGGK HSTGNEFMETAAVTVALTMPNVLVDTSGLKSQVKLFGMNTEFPLQKQIGTKTAAVGNE RVEMFYNKVKAPAVNYYDLEVNKTGHYFTHPSNKSEQTTAKAEKTLSTLPEGTVSEVY LSYDRAYPTKDVYNKFKGYDVSFLWNAIETEKNTNKTASTEPLGYPGKDSKFLAALNT KGKSNGDQFINALKFMSKHEKWAQVISKRKDLNVDNRLDYVEKNGVNVYGSVVTGPTK EIQRMLKNKSVKSANVGEVELWNW*" /label="asiMA CDS" gene complement(952736..953812) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /label="asiMA gene" CDS complement(953802..954293) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14651641, 14769884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14651641, 14769884; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M))" /protein_id="NP_388833.1" /db_xref="EnsemblGenomes-Gn:BSU09520" /db_xref="EnsemblGenomes-Tr:CAB12791" /db_xref="GOA:O07582" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13019" /db_xref="UniProtKB/Swiss-Prot:O07582" /translation="MTIDEIYQMYMNDVYRFLLSMTKDKHLAEDLLQETFMRAYIHIH SYDHSKVKPWLFQVARNAFIDYVRKHKKEVTISDDLIGSLFQNAVQSPAHQVEIKEVL TGYMSELPDNYREALTLYYLKELNYKEASHIMNISEANFKSVLFRARQRLKALYNRGV NDE*" /label="sigM CDS" gene complement(953802..954293) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /label="sigM gene" S_feature complement(954294..954396) /Source="Nicolas_S_feature" /locus_tag="new_1030069_1030171_c" /HighExp="Cold, LBGstat, H2O2, G180, Paraq, Oxctl, G135, HPh, dia15, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S330" promotor_-10 complement(954385..954404) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(954396) /Source="Nicolas_upshifts" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(954418..954421) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 954434..954440 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 954451 /Source="Nicolas_upshifts" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 954455..954473 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(954484) /Source="Nicolas_upshifts" /id="D500" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="2.13683" /MaxDrop="4.59517" /score="8.96845329" /energy="-10.2" /TU="NA" /idTUdmin="U757" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS 954490..955485 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10220166, 15019785, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15019785, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldo/keto reductase specific for NADPH; protectsagainst methylglyoxal" /protein_id="NP_388834.1" /db_xref="EnsemblGenomes-Gn:BSU09530" /db_xref="EnsemblGenomes-Tr:CAB12792" /db_xref="GOA:P80874" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PZ1" /db_xref="SubtiList:BG13020" /db_xref="UniProtKB/Swiss-Prot:P80874" /translation="MEYTSIADTGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAAL DQGITLIDTAPAYGFGQSEEIVGKAIKEYGKRDQVILATKTALDWKNNQLFRHANRAR IVEEVENSLKRLQTDYIDLYQVHWPDPLVPIEETAEVMKELYDAGKIRAIGVSNFSIE QMDTFRAVAPLHTIQPPYNLFEREMEESVLPYAKDNKITTLLYGSLCRGLLTGKMTEE YTFEGDDLRNHDPKFQKPRFKEYLSAVNQLDKLAKTRYGKSVIHLAVRWILDQPGADI ALWGARKPGQLEALSEITGWTLNSEDQKDINTILENTISDPVGPEFMAPPTREEI*" /label="akrN CDS" gene 954490..955485 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /label="akrN gene" downshifts 955464 /Source="Nicolas_upshifts" /id="D501" /incds=0 /nref=59 /ntot=160 /MaxReadThrough="6.85446" /MaxDrop="4.90106" /score="10.4379759" /energy="-11.8" /TU="U755" /idTUdmin="U756" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 955547..955550 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 955565..955584 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 955570 /Source="Nicolas_upshifts" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="upshifts" CDS 955620..956219 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /EC_number="2.3.1.51" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1557036, 17557823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1557036, 17557823; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-acylglycerol-phosphate (1-acyl-G3P) acyltransferase" /protein_id="NP_388835.1" /db_xref="EnsemblGenomes-Gn:BSU09540" /db_xref="EnsemblGenomes-Tr:CAB12793" /db_xref="GOA:O07584" /db_xref="InterPro:IPR002123" /db_xref="InterPro:IPR004552" /db_xref="SubtiList:BG13021" /db_xref="UniProtKB/Swiss-Prot:O07584" /translation="MYKFCANALKVILSLRGGVKVYNKENLPADSGFVIACTHSGWVD VITLGVGILPYQIHYMAKKELFQNKWIGSFLKKIHAFPVDRENPGPSSIKTPIKLLKE GEIVGIFPSGTRTSEDVPLKRGAVTIAQMGKAPLVPAAYQGPSSGKELFKKGKMKLII GEPLHQADFAHLPSKERLAAMTEALNQRIKELENKLDQL*" /label="plsC CDS" gene 955620..956219 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /label="plsC gene" downshifts 956234 /Source="Nicolas_upshifts" /id="D502" /incds=0 /nref=189 /ntot=245 /MaxReadThrough="6.36101" /MaxDrop="7.07164" /score="-7.3088084" /energy="-6.1" /TU="U755" /idTUdmin="U756" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 956279..958233 /Source="Nicolas_S_feature" /locus_tag="new_1032054_1034008" /HighExp="Cold, C30, S8, T-4.40H, Sw, Fru, S0, S7, HPh, G135" /AntisenseName="yhdP" /AntisenseCor="-0.46228251493795502" /AntisenseRegPval="-14.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S331" CDS complement(956288..957622) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /function="16.1: Circulate" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 25182490; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative magnesium efflux pump" /protein_id="NP_388836.1" /db_xref="EnsemblGenomes-Gn:BSU09550" /db_xref="EnsemblGenomes-Tr:CAB12794" /db_xref="GOA:O07585" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13022" /db_xref="UniProtKB/Swiss-Prot:O07585" /translation="MDIVNLILVAVLIALTAFFVASEFAIIRIRGSRIDQLIAEGNKA AIAVKKVTTHLDEYLSACQLGITLTSIGLGVLGESTIERLLHPLFVQMNVPGSLSHVI SFIFAYAIITFLHVVVGELAPKTVAIQKAEAVSMLFAKPLIWFYRIAFPFIWLLNNSA RLLTKAFGLETVSENELAHSEEELRIILSESYKSGEINQSEFKYVNKIFEFDDRLAKE IMIPRTEIVSLPHDIKISEMMDIIQIEKYTRYPVEEGDKDNIIGVINIKEVLTACISG EVSVDSTISQFVNPIIHVIESAPIQDLLVKMQKERVHMAILSDEYGGTAGLVTVEDII EEIVGEIRDEFDIDEISEIRKIGEGHYILDGKVLIDQVNDLLGIHLENEEVDTIGGWF LTQKYDVEKDDSIIEEGCEFIINEIDGHHVAYIEVKKLQEEELLETANQQEA*" /label="yhdP CDS" gene complement(956288..957622) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /label="yhdP gene" downshifts complement(956307) /Source="Nicolas_upshifts" /id="D503" /incds=0 /nref=284 /ntot=315 /MaxReadThrough="1.96991" /MaxDrop="7.22379" /score="11.1466394" /energy="-9.1" /TU="NA" /idTUdmin="U757" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" CDS complement(957683..958114) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 18048925" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 18048925; Product type r: regulator" /codon_start=1 /transl_table=11 /product="indirect copper efflux transcriptional regulator" /protein_id="NP_388837.1" /db_xref="EnsemblGenomes-Gn:BSU09560" /db_xref="EnsemblGenomes-Tr:CAB12795" /db_xref="GOA:O07586" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13023" /db_xref="UniProtKB/Swiss-Prot:O07586" /translation="MVGRDIDGAETYRISELAALAGVTKRTVDYYTNLGLLTPARSCS NYRYYDENALKRLIFIVDCKKQRLALSDIKDRLENQFPSSAKLDDEIGNLALEIDHMN QNISGILHRFERLKPEDRDKLKSKLPPEKLAVFQSFMLLLS*" /label="cueR CDS" gene complement(957683..958114) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /label="cueR gene" promotor_-10 complement(958126..958145) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(958136) /Source="Nicolas_upshifts" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(958160..958166) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(958162..958262) /Source="Nicolas_upshift_promotors" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 958197..958204 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-35" upshifts complement(958202) /Source="Nicolas_upshifts" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 958218..958237 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-10" upshifts 958235 /Source="Nicolas_upshifts" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="upshifts" CDS 958271..959452 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965, 15103638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_388838.1" /db_xref="EnsemblGenomes-Gn:BSU09570" /db_xref="EnsemblGenomes-Tr:CAB12796" /db_xref="GOA:O07587" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13024" /db_xref="UniProtKB/Swiss-Prot:O07587" /translation="MKLAGLSREVEENLNKGSWIRKLFDEGARLKKEFGEDQVFDFSL GNPIVEPPEAFKRALIEEAEKGSHGYIQNQGLLAAREKVAQFLGSRFEADFSAERIVM TVGAGGALNVALKSIVNPGEEVIILAPYFAEYKLYIENYGGKAVSCPLTSRFEIDIEA VRQSITPQTKGLILNTPHNPTGTVLSQKNIDDLGALLKEIEEKSGQTIYVLFDEPYSQ LIYDEELANPFQSYHRVILASSFSKDLGIAGERLGYIGLDSRMPDADLLINAFVYCNR TLGFVNAPVMMQRAVARMDDLRVDASAYKERRDLMVDILKEAGFEFEMPKGGFFVFPK SPIEDEVAFCVHAAQKYKLLIVPSSGFGMSGHFRLSFSVPIEQIKNSRDIFISLYKDF A*" /label="yhdR CDS" gene 958271..959452 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /label="yhdR gene" downshifts 959437 /Source="Nicolas_upshifts" /id="D504" /incds=0 /nref=12 /ntot=180 /MaxReadThrough="2.81766" /MaxDrop="3.37889" /score="-5.8634451" /energy="-9.1" /TU="U759" /idTUdmin="U759" /TUdmin="-163" /isTUend="FALSE" /label="downshifts" S_feature 959482..959620 /Source="Nicolas_S_feature" /locus_tag="new_1035257_1035395" /HighExp="Etha, S1, BMM, S2, Cold, MG 45, MG 25, C90, T-5.40H, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S332" misc_feature 959616..959635 /Source="Nicolas_upshift_promotors" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 959622..959778 /Source="Nicolas_S_feature" /locus_tag="new_1035397_1035553" /HighExp="M9-stat, B60, T4.0H, T3.0H, LoTm, S5, T5.0H, S4, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S333" upshifts 959622 /Source="Nicolas_upshifts" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="upshifts" CDS 959779..961164 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388840.1" /db_xref="EnsemblGenomes-Gn:BSU09590" /db_xref="EnsemblGenomes-Tr:CAB12798" /db_xref="GOA:O07589" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13026" /db_xref="UniProtKB/Swiss-Prot:O07589" /translation="MDDIDSLILIGVLIALTAFFVASEFAIVRVRRSRIDQLITEGNK RAILARRVITDLDEYLSASQLGITLTSIGLGVLGEPAFERLLHPLFEPLGLPDSVSHA VSFAVAYGLITFLHVVVGELAPKTVAIQKAEQLTLLIAGPLRLFYLLLFPFIWILNGS ARLLCGMFGLKPASEHDGSHSEEELRMLLSESLKNGEINPSEYKYVNKIFEFDNRIAK EIMIPRKEMAAVSTEMTMAEMLEVMLKEKYTRWPVTDGDKDSVLGLVNTKHLFSDLLF MTEEERMKMTIHPYVRPVIEVIETIPVHDLLIKMQRERIHMAILSDEYGGTSGLVTTE DILEEIVGEIRDEFDEDEQPLIQKLGDGHYVMDGKVRIDQVNSLLGASIQEDVDTIGG LILKENIDIEAGESIRIGSYTIKVLKMDGRLIKQIDIKEEAGNTTGITAHHKLPLPEP VMLNSATLSEK*" /label="yhdT CDS" gene 959779..961164 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /label="yhdT gene" downshifts 961054 /Source="Nicolas_upshifts" /id="D505" /incds=1 /nref=120 /ntot=240 /MaxReadThrough="5.11037" /MaxDrop="3.79021" /score="19.6985636" /energy="-10.5" /TU="U760" /idTUdmin="U760" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 961140 /Source="Nicolas_upshifts" /id="D506" /incds=0 /nref=129 /ntot=245 /MaxReadThrough="1.68999" /MaxDrop="6.12682" /score="19.6985636" /energy="-10.5" /TU="NA" /idTUdmin="U760" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(961178..961534) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 17196979, 22194412, 27824896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fluoride efflux channel component A" /protein_id="NP_388841.1" /db_xref="EnsemblGenomes-Gn:BSU09600" /db_xref="EnsemblGenomes-Tr:CAB12799" /db_xref="GOA:O07590" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13027" /db_xref="UniProtKB/Swiss-Prot:O07590" /translation="MTLAGIFIGGGLGAMLRFWLGNVITAKTKGLSLPIGILTVNILG ALGLGIFTGLHVANASVSLIIGTGFFGAFTTFSTFSVETIQLLMAKRVKESILYIVLT LCGSLFAFWCGWTITI*" /label="crcBA CDS" gene complement(961178..961534) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /label="crcBA gene" CDS complement(961531..961926) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /function="16.1: Circulate" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 22194412, 27824896; Product type t : transporter" /codon_start=1 /transl_table=11 /product="subunit of fluoride efflux transporter" /protein_id="NP_388842.1" /db_xref="EnsemblGenomes-Gn:BSU09610" /db_xref="EnsemblGenomes-Tr:CAB12800" /db_xref="GOA:O07591" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13028" /db_xref="UniProtKB/Swiss-Prot:O07591" /translation="MKIYSAVFIGGALGACLRYGLNLWIHTGQFPAATWLENAAGSLL LGILTGFFMIGAKRPLLSAFLGTGFCGGFTTMSTFSKETVMLLQGQPSLALLYVAASL ISGIIFALIGVFVGRRIAGIQQRKGLQEK*" /label="crcBB CDS" gene complement(961531..961926) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /label="crcBB gene" CDS complement(961913..962644) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /EC_number="3.1.4.46" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8012593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycerophosphodiester phosphodiesterase" /protein_id="NP_388843.1" /db_xref="EnsemblGenomes-Gn:BSU09620" /db_xref="EnsemblGenomes-Tr:CAB12801" /db_xref="GOA:O07592" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG13029" /db_xref="UniProtKB/Swiss-Prot:O07592" /translation="MYIIAHRGASGYAPENTIAAFDLAVKMNADMIELDVQLTKDRQI VVIHDDRVDRTTNGSGFVKDFTLEELQKLDAGSWYGPAFQGERIPTLEAVLKRYHKKI GLLIELKGHPSQVGIEEEVGQLLGQFSFSINNIVQSFQFRSVQRFRELYPSIPTAVIT RPNFGMLSRNQMKAFRSFANYVNIKHTRLNRLMIGSINKNGLNIFAWTVNNQKTAAKL QAMGVDGIVTDYPDFIIKDGKHENI*" /label="yhdW CDS" gene complement(961913..962644) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /label="yhdW gene" misc_feature complement(962669..962688) /Source="Nicolas_upshift_promotors" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(962690) /Source="Nicolas_upshifts" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 962737..962745 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 962754 /Source="Nicolas_upshifts" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 962759..962774 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 962768..962841 /Source="Nicolas_S_feature" /locus_tag="new_1038543_1038616" /HighExp="S5, S4, S6, S7, S8, S3, B60, Pyr, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.563" /TUlongSig="NA" /TUlongPSig="NA" /label="S334" promotor_-35 962828..962829 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 962843 /Source="Nicolas_upshifts" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 962845..962864 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-10" CDS 962878..962985 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388844.1" /db_xref="EnsemblGenomes-Gn:BSU09630" /db_xref="EnsemblGenomes-Tr:CAB12802" /db_xref="InterPro:IPR035384" /db_xref="SubtiList:BG13030" /db_xref="UniProtKB/Swiss-Prot:O07593" /translation="MGKGRIRVEERIKAETDAEMQKATLLDQTQTKKGK*" /label="yhdX CDS" gene 962878..962985 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /label="yhdX gene" S_feature 962986..963039 /Source="Nicolas_S_feature" /locus_tag="new_1038761_1038814" /HighExp="Sw, BC, LPhT, HiOs, S4, HiTm, S5, B36, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S335" downshifts 963010 /Source="Nicolas_upshifts" /id="D507" /incds=0 /nref=177 /ntot=225 /MaxReadThrough="0.97838" /MaxDrop="7.47175" /score="21.9742676" /energy="-14.5" /TU="NA" /idTUdmin="U762" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 963090..963109 /Source="Nicolas_upshift_promotors" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 963096 /Source="Nicolas_upshifts" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 963134..964249 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /function="16.8: Protect" /function="16.12: Sense" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12077558, 15849754, 16850406, 17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12077558, 15849754, 16850406, 17665170, 18310427, 19252899; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small conductance mechano-sensitive channel" /protein_id="NP_388845.1" /db_xref="EnsemblGenomes-Gn:BSU09640" /db_xref="EnsemblGenomes-Tr:CAB12803" /db_xref="GOA:O07594" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR006686" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13031" /db_xref="UniProtKB/Swiss-Prot:O07594" /translation="MPDYLQQYFTLDNIIQIGISLAILLVFLILRKLFTRYFFNLLFN LTNRPKTEIFKQVVLAFDKPARWFFVALGLFLAIRYSPFLDEQMPVISKIYRSLIVAL LCWGLCNLTATSSFIFHKVNQRFELDMDDILAPFLSKLLRFVIIALSVSVIAQEFNYD VNGFVAGLGLGGLAFALAAKDTISNFFGGIIIITEKPFTIGDWVETSTVTGSVEDITF RSTRFRTAQGALVTVPNSTLSMEAITNWTRMTKRQITFSIHVSYATPIENLERSIHSL RTMLLEHEGVDNEIIMVNFDTFADSYYNLFFNFYTKTTVWAENLNIREDINYKIIEIL GAEGVQFAYPGQMVVVKQKHESDQFQVNLNKEEKERA*" /label="mscY CDS" gene 963134..964249 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /label="mscY gene" downshifts 964229 /Source="Nicolas_upshifts" /id="D508" /incds=0 /nref=5 /ntot=141 /MaxReadThrough="3.45709" /MaxDrop="3.93891" /score="2.31392404" /energy="-12.3" /TU="U764" /idTUdmin="U764" /TUdmin="-783" /isTUend="FALSE" /label="downshifts" misc_feature 964286..964305 /Source="Nicolas_upshift_promotors" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 964286 /Source="Nicolas_upshifts" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 964319..965062 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16768447, 19136592, 26708127, 27987242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16768447, 19136592, 26708127, 27987242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirtuin NAD-dependent deacetylase" /protein_id="NP_388846.1" /db_xref="EnsemblGenomes-Gn:BSU09650" /db_xref="EnsemblGenomes-Tr:CAB12804" /db_xref="GOA:O07595" /db_xref="InterPro:IPR003000" /db_xref="InterPro:IPR026590" /db_xref="InterPro:IPR028628" /db_xref="InterPro:IPR029035" /db_xref="SubtiList:BG13032" /db_xref="UniProtKB/Swiss-Prot:O07595" /translation="METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASR MEAMSLDYFLSYPRLFWPKFKELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNI DGLHKKAGSRHVYELHGSIQTAACPACGARYDLPHLLEREVPECTAAGNNGDICGTVL KTDVVLFGDAVMHFDTLYEKLDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIIN LEPTYCDSLFDMVIHQKIGEFARSLGMKK*" /label="srtN CDS" gene 964319..965062 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /label="srtN gene" downshifts 965034 /Source="Nicolas_upshifts" /id="D509" /incds=0 /nref=3 /ntot=82 /MaxReadThrough="1.93149" /MaxDrop="2.85561" /score="9.76884826" /energy="-9.2" /TU="NA" /idTUdmin="U765" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(965086..965934) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide deacetylase" /protein_id="NP_388847.1" /db_xref="EnsemblGenomes-Gn:BSU09660" /db_xref="EnsemblGenomes-Tr:CAB12805" /db_xref="GOA:O07596" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG13046" /db_xref="UniProtKB/Swiss-Prot:O07596" /translation="MRQTRGEASPSAVSLAFKFASLAVLCVLLLLMVILGYSNSSTKA KEVTVTTNGQLRDEKESLKLKNDSPDLLIKHLQTKQNMGDKTVYLTFDDGPSAVTTRL LDVLKSADVKATFFMLSPRMNEFKQAVKRAEKEGHALGLHGVTHNNRLFYQTPTSPLK EMQEARDTLQDITGYKTDLVRTPYGSKPSLTASQIRNLEKDGFVYWDWTIDSMDWKYR NSQYVTAVLQQLENMEHSSSSRPNVILMHDLPATVNALPVLINKLKEKGYSFGVLEDT MVPVHE*" /label="yheN CDS" gene complement(965086..965934) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /label="yheN gene" downshifts complement(965110) /Source="Nicolas_upshifts" /id="D510" /incds=0 /nref=126 /ntot=242 /MaxReadThrough="2.03966" /MaxDrop="4.72968" /score="-7.82934513" /energy="-9.2" /TU="NA" /idTUdmin="U767" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 965930..965935 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(965935..966034) /Source="Nicolas_S_feature" /locus_tag="new_1041710_1041809_c" /HighExp="Cold, T3.0H, T2.30H, T3.30H, T4.0H, T2.0H, HPh, C30, T1.30H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S336" promotor_-10 965951..965969 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 965953 /Source="Nicolas_upshifts" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="upshifts" S_feature 965958..966153 /Source="Nicolas_S_feature" /locus_tag="new_1041733_1041928" /HighExp="S5, S4, S6, S3, S7, S8, LoTm, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S337" promotor_-10 complement(966023..966042) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(966037) /Source="Nicolas_upshifts" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(966057..966060) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 966152..966171 /Source="Nicolas_upshift_promotors" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 966155..966218 /Source="Nicolas_S_feature" /locus_tag="new_1041930_1041993" /HighExp="BC, T2.30H, T3.0H, T3.30H, T4.0H, T5.0H, T2.0H, T1.30H, S4, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S338" upshifts 966155 /Source="Nicolas_upshifts" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="upshifts" CDS 966219..967067 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /EC_number="2.6.1.21" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9003455, 17005988; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine aminotransferase" /protein_id="NP_388848.1" /db_xref="EnsemblGenomes-Gn:BSU09670" /db_xref="EnsemblGenomes-Tr:CAB12806" /db_xref="GOA:O07597" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005784" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG13045" /db_xref="UniProtKB/Swiss-Prot:O07597" /translation="MKVLVNGRLIGRSEASIDLEDRGYQFGDGIYEVIRVYKGVLFGL REHAERFFRSAAEIGISLPFSIEDLEWDLQKLVQENAVSEGAVYIQTTRGVAPRKHQY EAGLEPQTTAYTFTVKKPEQEQAYGVAAITDEDLRWLRCDIKSLNLLYNVMTKQRAYE AGAFEAILLRDGVVTEGTSSNVYAVINGTVRTHPANRLILNGITRMNILGLIEKNGIK LDETPVSEEELKQAEEIFISSTTAEIIPVVTLDGQSIGSGKPGPVTKQLQAAFQESIQ QAASIS*" /label="dat CDS" gene 966219..967067 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /label="dat gene" downshifts 967058 /Source="Nicolas_upshifts" /id="D511" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="2.27201" /MaxDrop="6.88888" /score="21.6239924" /energy="-11.5" /TU="U768" /idTUdmin="U766" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(967110..968471) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735849, 11274110, 15849754, 16850406, 17937670" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 11274110, 15849754, 16850406, 17937670; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_388849.1" /db_xref="EnsemblGenomes-Gn:BSU09680" /db_xref="EnsemblGenomes-Tr:CAB12807" /db_xref="GOA:O07553" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG13044" /db_xref="UniProtKB/Swiss-Prot:O07553" /translation="MDSQKKLTFPLAVGLFIFMLCIIISCLFLLHVEPHIPLFLSVVM LSAAALWFGFPWKSIEKGIVDGIKNGVQPIIVLALIGILIGAWMYSGAIPTMTVYALS FIEPSHLLLTALFSCMIISTLVGSSLTTVSTIGVALIGVASAAGVPLEWTAGAVICGA CFGDKMSPMSDTTNFAAGIGEIPIFEHIRHMMGTTIPALLITVVLFYFLGSSVSADAA STDNIQQVITGIKDAANVTPWALLSPLLVVLLAMKRVSVIPVLTAGIISSGILTAIFV PYSSLQAFMTALQNGTTFETDNEAAAKIINRGGLQSMMGSVSLIMIAFALGGLMEKIG LISALLEGVMKGIRSKGRLVAATVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQ RKFLTRSLEDGGTLINPLIPWGVSGAFMASALGVPVIDYIPFTFFLYISPMISILIGF VKK*" /label="nhaC CDS" gene complement(967110..968471) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /label="nhaC gene" downshifts complement(967134) /Source="Nicolas_upshifts" /id="D512" /incds=0 /nref=7 /ntot=77 /MaxReadThrough="0.50034" /MaxDrop="3.60175" /score="1.04025421" /energy="-11.5" /TU="NA" /idTUdmin="U769" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(968472..968542) /Source="Nicolas_S_feature" /locus_tag="new_1044247_1044317_c" /HighExp="B60, G135, Etha, LBGexp, G150, Diami, Paraq, G180, H2O2, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S339" misc_feature complement(968515..968534) /Source="Nicolas_upshift_promotors" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(968542) /Source="Nicolas_upshifts" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(968598..969098) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /function="16.12: Sense" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 16159758, 27464829; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein, UspA family" /protein_id="NP_388850.2" /db_xref="EnsemblGenomes-Gn:BSU09690" /db_xref="EnsemblGenomes-Tr:CAB12808" /db_xref="GOA:O07552" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13043" /db_xref="UniProtKB/Swiss-Prot:O07552" /translation="MFHADRIIVAFDGSENSKKALLTAIDLAKTVNAAITVAHSHDMK DNQTVIDPPRPAAEASYISGGMTSVPDPLISDVTSPEPMIYEDRTEEVIAEARMMLNE QQADGDIDILEGDPAESIIEHANRISADMIVTGSRDQNRLKKLIFGSVSEKLSAKSDI PVLIVK*" /label="nhaX CDS" gene complement(968598..969098) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /label="nhaX gene" downshifts complement(968630) /Source="Nicolas_upshifts" /id="D513" /incds=0 /nref=10 /ntot=63 /MaxReadThrough="4.74071" /MaxDrop="5.69273" /score="4.44189378" /energy="-12.2" /TU="U770" /idTUdmin="U770" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(969120..969138) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(969140) /Source="Nicolas_upshifts" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(969153..969159) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 969177..969184 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 969192..969261 /Source="Nicolas_S_feature" /locus_tag="new_1044967_1045036" /HighExp="C90, M9-stat, BC, T1.30H, T3.30H, Sw, T5.0H, GM 15, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S340" upshifts 969193 /Source="Nicolas_upshifts" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 969199..969218 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 969262..969423 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /experiment="publication(s) with functional evidences, PMID:25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25217586; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator leader peptide" /protein_id="NP_388851.1" /db_xref="EnsemblGenomes-Gn:BSU09700" /db_xref="EnsemblGenomes-Tr:CAB12809" /db_xref="SubtiList:BG13042" /db_xref="UniProtKB/Swiss-Prot:O07551" /translation="MFIKQFHIGAANLLFCFRERFFRSDRALKSAVRNISVKKGMELT LHAFFIYKI*" /label="bmrB CDS" gene 969262..969423 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /label="bmrB gene" downshifts 969353 /Source="Nicolas_upshifts" /id="D514" /incds=1 /nref=29 /ntot=180 /MaxReadThrough="5.31538" /MaxDrop="4.59672" /score="25.6910195" /energy="-14.4" /TU="U771" /idTUdmin="U768" /TUdmin=2273 /isTUend="FALSE" /label="downshifts" S_feature 969424..969542 /Source="Nicolas_S_feature" /locus_tag="new_1045199_1045317" /HighExp="LPhT, S7, S6, T-1.10H, Sw, LBGstat, S5, T-0.40H, S8, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S341" CDS 969543..971300 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388852.1" /db_xref="EnsemblGenomes-Gn:BSU09710" /db_xref="EnsemblGenomes-Tr:CAB12810" /db_xref="GOA:O07550" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13041" /db_xref="UniProtKB/Swiss-Prot:O07550" /translation="MFSVLKKLGWFFKAYWLRYTIAIVLLLAVNVIEMFPPKLLGNAI DDMKAGAFTAEGLLFYIGIFFVLTAAVYIMSYFWMHQLFGGANLMEKILRTKLMGHLL TMSPPFYEKNRTGDLMARGTNDLQAVSLTTGFGILTLVDSTMFMMTIFLTMGFLISWK LTFAAIIPLPVMAIAISLYGSKIHERFTEAQNAFGALNDRVLESVSGVRVIRAYVQET NDVRRFNEMTADVYQKNMKVAFIDSLFEPTVKLLVGASYLIGLGYGAFLVFRNELTLG ELVSFNVYLGMMIWPMFAIGELINVMQRGNASLDRVNETLSYETDVTDPKQPADLKEP GDIVFSHVSFTYPSSTSDNLQDISFTVRKGQTVGIAGKTGSGKTTIIKQLLRQYPPGE GSITFSGVPIQQIPLDRLRGWIGYVPQDHLLFSRTVKENILYGKQDATDKEVQQAIAE AHFEKDLHMLPSGLETMVGEKGVALSGGQKQRISIARALMANPEILILDDSLSAVDAK TEAAIIKNIRENRKGKTTFILTHRLSAVEHADLILVMDGGVIAERGTHQELLANNGWY REQYERQQLFTAEEGGAGA*" /label="bmrC CDS" gene 969543..971300 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /label="bmrC gene" CDS 971297..973318 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding subunit)" /protein_id="NP_388853.1" /db_xref="EnsemblGenomes-Gn:BSU09720" /db_xref="EnsemblGenomes-Tr:CAB12811" /db_xref="GOA:O07549" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13040" /db_xref="UniProtKB/Swiss-Prot:O07549" /translation="MKIGKTLWRYALLYRKLLITAVLLLTVAVGAELTGPFIGKKMID DHILGIEKTWYEAAEKDKNAVQFHGVSYVREDRLQEPVSKAKEAHIYQVGMAFYFVDQ AVSFDGNRTVSDGKLTITNGDKSRAYAAEKLTKQELFQFYQPEIKGMVLLICLYGGLL VFSVFFQYGQHYLLQMSANRIIQKMRQDVFSHIQKMPIRYFDNLPAGKVVARITNDTE AIRDLYVTVLSTFVTSGIYMFGIFTALFLLDVKLAFVCLAIVPIIWLWSVIYRRYASY YNQKIRSINSDINAKMNESIQGMTIIQAFRHQKETMREFEELNESHFYFQNRMLNLNS LMSHNLVNVIRNLAFVCLIWHFGGASLNAAGIVSIGVLYAFVDYLNRLFQPITGIVNQ FSKLELARVSAGRVFELLEEKNTEEAGEPAKERALGRVEFRDVSFAYQEGEEVLKHIS FTAQKGETVALVGHTGSGKSSILNLLFRFYDAQKGDVLIDGKSIYNMSRQELRSHMGI VLQDPYLFSGTIGSNVSLDDERMTEEEIKNALRQVGAEPLLKKLPKGINEPVIEKGST LSSGERQLISFARALAFDPAILILDEATAHIDTETEAVIQKALDVVKQGRTTFVIAHR LSTIRNADQILVLDKGEIVERGNHEELMALEGQYYQMYELQKGQKHSIA*" /label="bmrD CDS" gene 971297..973318 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /label="bmrD gene" downshifts 973306 /Source="Nicolas_upshifts" /id="D515" /incds=0 /nref=69 /ntot=230 /MaxReadThrough="0.741399999999999" /MaxDrop="5.11492" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U771" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(973367..973987) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-flavin oxidoreductase" /protein_id="NP_388854.1" /db_xref="EnsemblGenomes-Gn:BSU09730" /db_xref="EnsemblGenomes-Tr:CAB12812" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13039" /db_xref="UniProtKB/Swiss-Prot:O07548" /translation="MKIALLGASGRVGQAFLTQAAADERFDIFALIRSQHADLPLSKD RTVMGNARRLEDVKKIMENAEIVISCLGTDGDDTLSTAMAHILSVMEEQHIKRLITIG TAGILDSRYEPGKYRFETNESKRKQTRAAKEHAKVYEMLKESSLDWTIICPTYLPDGT ATGVYRTERNVLPEGGTSISVGDTADFLYRELVTGEYVGNRVGLAY*" /label="yheG CDS" gene complement(973367..973987) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /label="yheG gene" downshifts complement(973382) /Source="Nicolas_upshifts" /id="D516" /incds=0 /nref=19 /ntot=169 /MaxReadThrough="1.82652" /MaxDrop="3.00293" /score="-0.293143554" /energy="-10.9" /TU="NA" /idTUdmin="U772" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 973972..974072 /Source="Nicolas_upshift_promotors" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(974001..974020) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(974016) /Source="Nicolas_upshifts" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="upshifts" CDS complement(974026..974151) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388855.1" /db_xref="EnsemblGenomes-Gn:BSU09740" /db_xref="EnsemblGenomes-Tr:CAB12813" /db_xref="SubtiList:BG13038" /db_xref="UniProtKB/Swiss-Prot:O07547" /translation="MSFITIVNWELVQFVSVSMIHEYVSHRSVYLYRYSFPRCSN*" /label="yheF CDS" gene complement(974026..974151) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /label="yheF gene" upshifts 974032 /Source="Nicolas_upshifts" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(974035..974038) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(974165..974184) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(974174) /Source="Nicolas_upshifts" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(974198..974207) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 974230 /Source="Nicolas_upshifts" /id="D517" /incds=0 /nref=6 /ntot=22 /MaxReadThrough="0.352760000000001" /MaxDrop="4.67633" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U773" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(974256..974459) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:3009398, 9572981, 16707666, 19659696, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009398, 9572981, 16707666, 19659696, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (beta-type SASP)" /protein_id="NP_388856.1" /db_xref="EnsemblGenomes-Gn:BSU09750" /db_xref="EnsemblGenomes-Tr:CAB12814" /db_xref="GOA:P04832" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10787" /db_xref="UniProtKB/Swiss-Prot:P04832" /translation="MANQNSSNDLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRANG SVGGEITKRLVSFAQQQMGGRVQ*" /label="sspB CDS" gene complement(974256..974459) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /label="sspB gene" downshifts complement(974261) /Source="Nicolas_upshifts" /id="D518" /incds=0 /nref=72 /ntot=93 /MaxReadThrough="1.27819" /MaxDrop="8.55895" /score="22.2113888" /energy="-16" /TU="NA" /idTUdmin="U776" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(974460..974570) /Source="Nicolas_S_feature" /locus_tag="new_1050235_1050345_c" /HighExp="S8, S5, S7, S6, S4, G/S, Pyr, ferm, BT, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S342" promotor_no_box 974500..974600 /Source="Nicolas_upshift_promotors" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 974560 /Source="Nicolas_upshifts" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(974576) /Source="Nicolas_upshifts" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(974580..974591) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(974606..974612) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(974668..974886) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation / germination island)" /protein_id="NP_388857.1" /db_xref="EnsemblGenomes-Gn:BSU09760" /db_xref="EnsemblGenomes-Tr:CAB12815" /db_xref="InterPro:IPR017263" /db_xref="SubtiList:BG13037" /db_xref="UniProtKB/Swiss-Prot:O07546" /translation="MAVMISHFSWKPLFPKEKLPGWKISFYYKGTHYEGIYHKSGEIE WGDLFPARADEPALTNEIHELMLFHIYD*" /label="yheE CDS" gene complement(974668..974886) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /label="yheE gene" downshifts complement(974702) /Source="Nicolas_upshifts" /id="D519" /incds=0 /nref=5 /ntot=83 /MaxReadThrough="0.43384" /MaxDrop="3.42951" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U777" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(974927..974946) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(974944) /Source="Nicolas_upshifts" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(974960..974967) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(975036..976397) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /function="16.5: Explore" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15231775, 25035995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 25035995; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat associated protein" /protein_id="NP_388858.2" /db_xref="EnsemblGenomes-Gn:BSU09770" /db_xref="EnsemblGenomes-Tr:CAB12816" /db_xref="GOA:O07545" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13036" /db_xref="UniProtKB/Swiss-Prot:O07545" /translation="MNPKRFLIGIDKTSENTLFLPSSLKQDGLLHAAFGTKVVRCHVA YRRHLEQTVLLSENLFHELLLPHRSRADILIHDHTVHIGPLVGIFTAGFTVSLERPFK DRSLFFSKLVTLHEQAGGYCFVFGAHQINWEEGTIEGLLYRENGWEKKIVPLPNVVYD RLPNRKIEDSLLLQHTKKRLIDEYQIPWFNKTFFNKWNVHQLLEKDPRTAPFLPRSEL TPSVELIDELCGAYKKVYIKPANGALGTGIYQLTRTDGGLTVKHTNDAKTFTSIDYSD AASFLAEFQKHHNPSDFLIQQGVDLIEFQGKPADFRVHTNKNRKGKWTVTAIAVKISG KNSITTHLSNGGTVKTLAEVYDDPAERVEVIKKLSAAALTASHVLHDHIEGFIGEIGF DFGIDQNGKVWMFEANSRPGRSIFSHPNLHHVDSLTKRRSFEYASYLSEKAITSPEAL WPS*" /label="spaD CDS" gene complement(975036..976397) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /label="spaD gene" downshifts complement(975054) /Source="Nicolas_upshifts" /id="D520" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.33323" /MaxDrop="3.7968" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(975098) /Source="Nicolas_upshifts" /id="D521" /incds=1 /nref=2 /ntot=45 /MaxReadThrough="5.29177" /MaxDrop="3.36501" /score="37.4339943" /energy="-11.8" /TU="U779" /idTUdmin="U779" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(976387..977478) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231775, 25035995; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat associated protein, subunit C" /protein_id="NP_388859.1" /db_xref="EnsemblGenomes-Gn:BSU09780" /db_xref="EnsemblGenomes-Tr:CAB12817" /db_xref="GOA:O07544" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13035" /db_xref="UniProtKB/Swiss-Prot:O07544" /translation="MITLGFMSLSRQHEADYSAELAKRAPEFGIRFIRFTPFDISPDT LRVKASVYHSASSTWNETEMAIPDYIYDRCFYGKDSHSQKAKPIVEWLKKYPKTEFIG RGLPDKWTVLHDLQQHSVINPYIPETIKVSRYEQIHSFLSKEKACILKPAFGAGGRGV ILLKLGKKNITATYHIGKDKQTKTFSNQTSFKTWCKKVLQHQYLLQPYLNIQDKEQYP CDIRLFMEKNEAGEWNTVGKAVRRGYKHGLLANLSGGSDALTFDSWFEDIPKKQQVVL LDDVFSITQSVPYYLDERYGPLFELGLDICLAKDGRIWILDINSKPGRKSILRVSPEQ KEQLYTCPLKRCQYLFSEQSQKGVLPRES*" /label="spaC CDS" gene complement(976387..977478) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /label="spaC gene" promotor_-10 complement(976802..976816) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(976814) /Source="Nicolas_upshifts" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(976830..976838) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(977479..977584) /Source="Nicolas_S_feature" /locus_tag="new_1053254_1053359_c" /HighExp="S4, B36, S5, S6, S7, S8, B60, S3, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S343" promotor_-10 complement(977568..977586) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(977588) /Source="Nicolas_upshifts" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(977602..977607) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 977650..977657 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 977672..977691 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 977683 /Source="Nicolas_upshifts" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="upshifts" CDS 977745..978878 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16684363" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388860.1" /db_xref="EnsemblGenomes-Gn:BSU09790" /db_xref="EnsemblGenomes-Tr:CAB12818" /db_xref="GOA:O07543" /db_xref="InterPro:IPR007383" /db_xref="InterPro:IPR016991" /db_xref="SubtiList:BG13034" /db_xref="UniProtKB/Swiss-Prot:O07543" /translation="MGIAGTFIFMIVIGAAIGAVTNHLAIQMLFRPYKAYYLFGKRVP FTPGLIPRRRDELAKQMGLMVVNHLLTPEGIKKRLVSDAAKTQALRVGEQLIQKLSLS EVTVKEALEKAGMKRPEKAADAWISSWTDDKLHELFRQYGDQSLKELVPIEVQEKLEE KIPMISGYILSRSVRYFESDEGKIRLGNMIDDFLKERGMLGSMVQLFLGNSSLADRVL PELLKFLRNEETNKLLSDLLKNEWGKLREYTFNEADEKWNAKALIFSLKRRVLQAFST APFFNNTIGTLTVRYESELTQQMLPALLDKLLEGISSNLESVLKRLRLEEIVKEQVDQ FPVERLEEMVLSISKKEFKMITYLGGLLGGIIGAIQALFVILF*" /label="yheB CDS" gene 977745..978878 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /label="yheB gene" S_feature 978879..978970 /Source="Nicolas_S_feature" /locus_tag="new_1054654_1054745" /HighExp="S4, S5, S6, BT, S3, S7, dia15, B36, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S344" CDS 978971..979324 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388861.1" /db_xref="EnsemblGenomes-Gn:BSU09800" /db_xref="EnsemblGenomes-Tr:CAB12819" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="PDB:2OEE" /db_xref="SubtiList:BG13033" /db_xref="UniProtKB/Swiss-Prot:O07542" /translation="MAVNFYDVAYDLENALRGSEEFTRLKNLYDEVNADESAKRMFEN FRDVQLRLQQKQMAGEEITQEEVTQAQKTVALVQQHEKISQLMEAEQRMSMLIGELNK IIMKPLEELYGSVEG*" /label="yheA CDS" gene 978971..979324 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /label="yheA gene" downshifts 979312 /Source="Nicolas_upshifts" /id="D522" /incds=0 /nref=159 /ntot=259 /MaxReadThrough="1.55668" /MaxDrop="5.9901" /score="24.5275597" /energy="-12.3" /TU="NA" /idTUdmin="U780" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(979368..980441) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290, 22933559" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388862.1" /db_xref="EnsemblGenomes-Gn:BSU09810" /db_xref="EnsemblGenomes-Tr:CAB12820" /db_xref="GOA:O07541" /db_xref="InterPro:IPR011989" /db_xref="InterPro:IPR014825" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR021133" /db_xref="SubtiList:BG13002" /db_xref="UniProtKB/Swiss-Prot:O07541" /translation="MADLKEIYNEELISQLIHHVRSSYPDFNKNRFLDTLRLEDWPEL TLKERMRRVTVSLYETLPKQYVEALTILRDTAPHFKGLSGILFPDYVEQYGLAHWEES IKALESFTQYSTSEFAVRPFLLLDQEKMIAQLLAWSEHKNEHVRRLASEGSRPRLPWG KSIPALKSDPSPVLPILEKLMQDESLYVRKSVANNLNDISKTHPHLLRKVADQWYGTH PHTDWIIKHAYRTLLKKGDKQALALFGYENADSIQLHDLTCQPKRIVIGESLEFSFYI HSDRDQKVRIEYAIDFVKARGQRHQKVFKITETNIRKNETKSYTRIQSFKDLTTRKHY KGIHTLSVIINGEVKDSLDFQVC*" /label="yhaZ CDS" gene complement(979368..980441) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /label="yhaZ gene" downshifts complement(979475) /Source="Nicolas_upshifts" /id="D523" /incds=1 /nref=16 /ntot=173 /MaxReadThrough="3.78071" /MaxDrop="3.586" /score="4.43596345" /energy="-12.3" /TU="U781" /idTUdmin="U781" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(980463..980482) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(980475) /Source="Nicolas_upshifts" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(980496..980503) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 980578..980585 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 980598 /Source="Nicolas_upshifts" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 980600..980619 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 980609..980762 /Source="Nicolas_S_feature" /locus_tag="new_1056384_1056537" /HighExp="M9-stat, BC, T0.30H, T1.30H, Lbstat, T1.0H, T3.30H, T2.0H, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S345" downshifts 980719 /Source="Nicolas_upshifts" /id="D524" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="7.40404" /MaxDrop="2.6506" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 980764..980847 /Source="Nicolas_S_feature" /locus_tag="new_1056539_1056622" /HighExp="M9-stat, B60, T2.0H, T1.30H, T0.30H, T2.30H, T3.0H, T1.0H, Lbtran, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S346" downshifts 980804 /Source="Nicolas_upshifts" /id="D525" /incds=0 /nref=70 /ntot=231 /MaxReadThrough="4.88371" /MaxDrop="4.4099" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-971" /isTUend="FALSE" /label="downshifts" promotor_-35 980860..980865 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 980881..980899 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 980890 /Source="Nicolas_upshifts" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 980927..981793 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388864.2" /db_xref="EnsemblGenomes-Gn:BSU09830" /db_xref="EnsemblGenomes-Tr:CAB12822" /db_xref="GOA:O07539" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR036412" /db_xref="PDB:3DNP" /db_xref="SubtiList:BG13000" /db_xref="UniProtKB/Swiss-Prot:O07539" /translation="MSKQLLALNIDGALLRSNGKIHQATKDAIEYVKKKGIYVTLVTN RHFRSAQKIAKSLKLDAKLITHSGAYIAEKIDAPFFEKRISDDHTFNIVQVLESYQCN IRLLHEKYSIGNKKKVNSNLLGKALIHPSDPIFYPVQFVESLSDLLMDEPVSAPVIEV YTEHDIQHDITETITKAFPAVDVIRVNDEKLNIVPKGVSKEAGLALVASELGLSMDDV VAIGHQYDDLPMIELAGLGVAMGNAVPEIKRKADWVTRSNDEQGVAYMMKEYFRMQQR KGFLDKFHMKRV*" /label="yhaX CDS" gene 980927..981793 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /label="yhaX gene" downshifts 981775 /Source="Nicolas_upshifts" /id="D526" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="3.99904" /MaxDrop="4.7771" /score="15.7706912" /energy="-16.6" /TU="U783" /idTUdmin="U782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 981838..981841 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 981856..981875 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 981864 /Source="Nicolas_upshifts" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 981905..983410 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /EC_number="1.3.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10498703, 21255303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498703, 21255303; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_388865.1" /db_xref="EnsemblGenomes-Gn:BSU09840" /db_xref="EnsemblGenomes-Tr:CAB12823" /db_xref="GOA:Q796V8" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023995" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG12999" /db_xref="UniProtKB/Swiss-Prot:Q796V8" /translation="MQIKIEGIHDDRLHRPLQNIANLFYEECELAYGGEEPADFVISL ALSQTDEHVTVSGEVKGTGIKEQHTKFFSPDMTEKEAFKQVKNTISYVYLNLLQAHTG ITQKWGILTGIRPTKLLHKKLQSGMSKEQAHAELKKDYLIHDEKIMLMQEIVDRQLAA VPDLYRVKDEVSIYIGIPFCPTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEW LKEHDVKVTTIYFGGGTPTSITAEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITE EKLAVLNKYDIDRISINPQSYENETLKAIGRHHTVEETIEKYHLSRQHGMNNINMDLI IGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTRNKHKYKVAGREEVSQMM EDAVAWTKEHGYVPYYLYRQKNILGNLENVGYSLPGQESIYNIMIMEEVQTIIGIGCG AASKFIDRDTGKITHFANPKDPKSYNERFEHYTDEKIKYLEQIFEKTTKQH*" /label="hemZ CDS" gene 981905..983410 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /label="hemZ gene" downshifts 983380 /Source="Nicolas_upshifts" /id="D527" /incds=0 /nref=113 /ntot=234 /MaxReadThrough="0.523269999999999" /MaxDrop="5.05369" /score="38.1573779" /energy="-14.4" /TU="NA" /idTUdmin="U783" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(983428..984645) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7934942, 14987767, 15849754, 15919996, 16850406, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934942, 14987767, 15849754, 15919996, 16850406, 24330391; Product type t : transporter" /codon_start=1 /transl_table=11 /product="proton/potassium antiporter; methylglyoxal resistance" /protein_id="NP_388866.2" /db_xref="EnsemblGenomes-Gn:BSU09850" /db_xref="EnsemblGenomes-Tr:CAB12825" /db_xref="GOA:O07536" /db_xref="InterPro:IPR006153" /db_xref="SubtiList:BG12997" /db_xref="UniProtKB/Swiss-Prot:O07536" /translation="MDHLVFEVGTALVLVAIASVIANKIKFSIIPFLIVLGMLVGPHA PKMGIIDLTFIQSSEIIEFFGRMGVLFLLFYLGLEFSVGKLIKSGKSIAVGGTIYILI NFSLGLLYGFITGFSFLEVLILAGVITISSSAIVAKVLVDLKRTANPETELILGIIMF EDIFLAVYLSVVSGLILGDATSVGSALLSILIAFGYMLLFFIAARKLPPLLNKLLDIR SNEVFIIVIFAALFFIAGFSETIHVAEAIGALLLGLVFSETEHSDRIEHLVVPFRDFF GAMFFFSFGLSIDPFSLGEAVWLALGAVILTILGNFIAGMVAGRRAGLSHKASSNIGL TIVSRGEFSIIVANLGIAGGLSATLKPFAALYVLILAILGPLVTKESKRIYRLLNKVF KWKPEVQPAKKQG*" /label="khtU CDS" gene complement(983428..984645) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /label="khtU gene" downshifts complement(983434) /Source="Nicolas_upshifts" /id="D528" /incds=0 /nref=154 /ntot=249 /MaxReadThrough="1.74386" /MaxDrop="6.8685" /score="8.64654688" /energy="-14.4" /TU="NA" /idTUdmin="U785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(984652..985149) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388867.1" /db_xref="EnsemblGenomes-Gn:BSU09860" /db_xref="EnsemblGenomes-Tr:CAB12826" /db_xref="GOA:O07535" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG12996" /db_xref="UniProtKB/Swiss-Prot:O07535" /translation="MNIKENDLPGIGKKFEIETRSHEKMTIIIHDDGRREIYRFNDRD PDELLSNISLDDSEARQIAAILGGMVYKPQALESIEMAFSDLIIEWFKVEKGAKSIGR TLGELDVRQNYDVTVIAIIKHNQEKLLNPGADSIIEENDTLVLSGERKHLKKLIHDFL SGEGV*" /label="khtT CDS" gene complement(984652..985149) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /label="khtT gene" CDS complement(985213..985551) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388868.1" /db_xref="EnsemblGenomes-Gn:BSU09870" /db_xref="EnsemblGenomes-Tr:CAB12827" /db_xref="GOA:O07534" /db_xref="SubtiList:BG12995" /db_xref="UniProtKB/Swiss-Prot:O07534" /translation="MRREERNMDKLLISFLLSLFMVYFPPSDVVLPSQFEASTDSYVP MSSYPQETQSAKTPSPGSMHPAELIKEYSPLAQSVRQLSVKPLDEPLINRLEKALAVP VKYQSNYLRI*" /label="khtS CDS" gene complement(985213..985551) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /label="khtS gene" promotor_-10 complement(985563..985582) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(985587) /Source="Nicolas_upshifts" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(985596..985603) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 985623..985630 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 985645..985664 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 985655 /Source="Nicolas_upshifts" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="upshifts" CDS 985716..986483 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22961985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase / isomerase" /protein_id="NP_388869.3" /db_xref="EnsemblGenomes-Gn:BSU09880" /db_xref="EnsemblGenomes-Tr:CAB12828" /db_xref="GOA:O07533" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12994" /db_xref="UniProtKB/Swiss-Prot:O07533" /translation="MEFVQYACNGAVAEIILNRPDAHHALNEQMLSELKEAVEMAAAS EALIVLLRGSGKGFSAGGDIRMMTSEHDPDQFKRLMDTIEAVTLNLYQMKKVTIAAIH GAAAGLGLSLALCADIVLAEKNAVLAMNFIGIGLVPDGGGHYLLKKRIGEAKAKKLIW SGKKLSASEAADMGLLDGTFAGDPAEGARPIIETLLASPLLAMIETKGIFQSLQIEEL KKVLSLERSAQERMRRTKDHQEGIRAFLEKREPKFQA*" /label="yhaR CDS" gene 985716..986483 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /label="yhaR gene" downshifts 986484 /Source="Nicolas_upshifts" /id="D529" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="1.78111" /MaxDrop="4.66019" /score="-8.79921781" /energy="-7.5" /TU="NA" /idTUdmin="U786" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(986504..986689) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097698.1" /db_xref="EnsemblGenomes-Gn:BSU09889" /db_xref="EnsemblGenomes-Tr:CAX52586" /db_xref="InterPro:IPR025544" /db_xref="UniProtKB/Swiss-Prot:C0H3Y1" /translation="MADYFLTVFDPSGNTLVNEQFEAEHEEAAKTHGEALLKEKELHS HTHRLVNAAGKLILFHR*" /label="yhzD CDS" gene complement(986504..986689) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /label="yhzD gene" promotor_-10 complement(986725..986743) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(986736) /Source="Nicolas_upshifts" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(986754..986762) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 986763..986766 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 986781..986800 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 986791 /Source="Nicolas_upshifts" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="upshifts" CDS 986816..987712 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 12374817; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388870.2" /db_xref="EnsemblGenomes-Gn:BSU09890" /db_xref="EnsemblGenomes-Tr:CAB12829" /db_xref="GOA:C0SPB4" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12993" /db_xref="UniProtKB/Swiss-Prot:C0SPB4" /translation="MLTIDHVTKTFGDYKAVDGLDLDIPEQQMFGLLGANGAGKTTTF RMILGLLSITEGSISWKGRPVNYHISNKIGYLPEERGLYPKMKVRDQLVYLARLKGME KREAVKELGTWLERFNITDYENKKVEELSKGNQQKIQFISAVLHKPELLILDEPFSGL DPVNVELLKEAVISLKNSGVSILFSSHRMEHVEELCENLCILQKGKPVVQGKLKEIKR SFGKKNVTIHSDDDLRFLQSHEGILQWKETADGVKLQIANEDISQEIFAMLQGKGFIR KFELEEPSLHDIFIEKVGAVYE*" /label="yhaQ CDS" gene 986816..987712 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /label="yhaQ gene" CDS 987705..988964 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent exporter (ABC permease)" /protein_id="NP_388871.2" /db_xref="EnsemblGenomes-Gn:BSU09900" /db_xref="EnsemblGenomes-Tr:CAB12830" /db_xref="GOA:O07523" /db_xref="SubtiList:BG12992" /db_xref="UniProtKB/Swiss-Prot:O07523" /translation="MNKFWIMLSHTYKNKIMAKSFIISTVITVLLVLVVTNLESIISL FQGDDAKEKIAVVDETNELYPVFSKQLKAVDTDGDLDVKLSKQSEDEVTKQVKDESLD GMLIIKRDEKGTISGTYKALTISDESTYQTLQQALTQTKTAVGTAELGVSQETISSLY APVTVGQKALKEGAKSEEELGQTVGLVYIMLFVIYFSVIMYASMIAMEVATEKSSRVM EILISSMPPIQQMFAKLLGIGLVGITQLAIIIGAGSLSLKLNQKSETASSVGGFLNLT DVSATTVIYAVIFFLLGYFLYATLAAFLGSVVSRIEDVQQTITPMTLLVVAGFMIAMF GLNAPDAGFITVTSFIPFFTPMIMFLRVGMLDIPFWQAAVGIGITLLTIVILAVIGAR IYKGGVLIYGNSSAFKAIKQALRLAKN*" /label="yhaP CDS" gene 987705..988964 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /label="yhaP gene" downshifts 988948 /Source="Nicolas_upshifts" /id="D530" /incds=0 /nref=19 /ntot=187 /MaxReadThrough="2.50232" /MaxDrop="3.26822" /score="8.93460501" /energy="-12.8" /TU="NA" /idTUdmin="U788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 989012..989019 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 989031..989050 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 989036 /Source="Nicolas_upshifts" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 989071..990297 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA repair exonuclease" /protein_id="NP_388872.1" /db_xref="EnsemblGenomes-Gn:BSU09910" /db_xref="EnsemblGenomes-Tr:CAB12831" /db_xref="GOA:O07522" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR014576" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12991" /db_xref="UniProtKB/Swiss-Prot:O07522" /translation="MLTDLTFIHAADLHLDSPFYGISHLPEPIFARIKESTFASVRHM IDAAVREHVDFILLAGDLFDEANRSLKAQLFLKKQFERLRECGISVYVIFGNHDHLGG EWTPIEWPENVHIFSSAVPEEKSFFKEGRRIASIYGFSYQARALMENQAARYRRSTDA PFHIGMLHGTLSGSEGHDPYCPFTHDDLVKSGMDYWALGHIHKRQVLSAEHPAVIYPG NTQARHIKETGDKGYYLVHVTNGDISYEFQRAHDVLWEKAAVDVTEAKNMTALFQMVE DTFSKLRKKGSPVCVRLVLQGTAPEWLLEAPKGTLDEFLEALQEQEAEEERFVWPLRL DDETENEANLTNLDPFFGGLFEDIDRSDLSDVLEGLERHPVYRRHADRFSQEEVKEIK EQAQIILKRQLKVLDT*" /label="yhaO CDS" gene 989071..990297 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /label="yhaO gene" downshifts complement(989772) /Source="Nicolas_upshifts" /id="D531" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="0.0165100000000002" /MaxDrop="3.62411" /score="-5.83060322" /energy="-15.2" /TU="NA" /idTUdmin="U787" /TUdmin="-3300" /isTUend="FALSE" /label="downshifts" CDS 990302..993193 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16267290, 19906728, 21517913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267290, 19906728, 21517913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATPase involved in DNA double strand break repair and recombination" /protein_id="NP_388873.1" /db_xref="EnsemblGenomes-Gn:BSU09920" /db_xref="EnsemblGenomes-Tr:CAB12832" /db_xref="GOA:O08455" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12990" /db_xref="UniProtKB/Swiss-Prot:O08455" /translation="MTALRIISLHIYQYGKFSNRTFDFSASPVQVIYGLNEAGKTTMM SFIESMLFGFPKTKKYEPKTGGVYGGVLEAEHPEYGVLKIERTKGTAEKLSVYTEKGE VKQGDVLKQLFQGTDRSLYKAIYSFDVFGLQEIHAFNRDKIGEFLLFSSLFGAEAVSK LDSRLTKESERLYKPNGRNPQLNQELETLKQLAVKLKQAEAEEAGYHQLLEEKRTLEA RLAAAETELKETAGHIRMIEGAIERKPLLNEKATLEQVIAEFPEHAGQFPADGLHQLE KYESHLHPKSAQLEALRVKMAELDKQRQKLIPDKELLAKETLIQELSAAFHMYQSWGE QLAAIQAQLRQTSAQTAAGLEQLNKTDENELLNMNTSYDYEWQLQQAVQQYVQARDRK RQLDETFELARQELEDAEKAVRAASSAILENSQRKDKEAALRAYDETQGQHQEQAKLR EQLTFFERQQAKQKKTVIAAGMLFIVLFSLLQQWIPAISFGAALIVYWLVSGKSSSRN SRETRQPMTDISPAEAEMLREALWEDDRNKQHLLTQRAALQQKEAAYERVIQQFEQWE AEMAPSFTQVERFMNELGFKEDPSFLLDAYSLMKDVKKEVKKKHELTIEAGRLKKHRR TFEERVSMLLPVNQSQDISISDALHTLRKNIEREKEIEKQKKEIETDIHYTKEQMLEL EQEIQYFHAQIEQLFAAAAAKDRDAFFAIAAISRQLKDTENKLHHVNAQLQGGYPEEL ELADSNTLSELKDKQFVENERKERLTEEIEQLRSQIALLSVKQEQLEASGMVSDLKLQ TEMQKERVKETAKKWASIQMVKQVIRNKLERHKKIELPRLLETAGEFFRPLTDGNYQT IYFSETDDSIMVMHRDGTVYHAEELSQGTCEQLYTAIRFALAVTRQGESKLPFQLDDS FVHFDQERLKRVLHVLYDLSEGGRQILYFTCHEHVKDAFHSSQIIHLVS*" /label="sbcE CDS" gene 990302..993193 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /label="sbcE gene" promotor_-35 991583..991588 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 991604..991622 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 991610 /Source="Nicolas_upshifts" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 993201..993206 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 993221..993240 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 993236 /Source="Nicolas_upshifts" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 993267..994211 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 16267290, 19553197, 19880604" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 16267290, 19553197, 19880604; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3'-5' exonuclease" /protein_id="NP_388874.1" /db_xref="EnsemblGenomes-Gn:BSU09930" /db_xref="EnsemblGenomes-Tr:CAB12833" /db_xref="GOA:O07521" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020873" /db_xref="SubtiList:BG12989" /db_xref="UniProtKB/Swiss-Prot:O07521" /translation="MAKGIMLHEVGEQVDQYLLIKSSTKGIASNGKPFLTLMLQDQSG DIEAKLWDAKQSDEVTYAPQTIVKVVGDVHHYRGRTQLKLRNIRPVSEQENVNIDDFL ETAPIPKNEMMDTITQYIFEMKNPNIQRITRFLVKKHEAEFMDYPAATKNHHEFVSGL AYHVVSMLNLAKAIADLYPSLDRDLLYAGVILHDLGKVKELSGPVSTSYTVEGNLLGH ISIMVTELSKAAEELQIDSEEVLILQHLILSHHGKAEWGSPKPPMVKEAEILHYIDNL DAKMNMMDRALERVKPGEYTERVFALENRSFYKPTFHK*" /label="yhaM CDS" gene 993267..994211 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /label="yhaM gene" downshifts 994189 /Source="Nicolas_upshifts" /id="D532" /incds=0 /nref=183 /ntot=261 /MaxReadThrough="3.02818" /MaxDrop="5.88173" /score="6.06919899" /energy="-15.8" /TU="NA" /idTUdmin="U789" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 994270..994275 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 994291..994309 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 994294 /Source="Nicolas_upshifts" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="upshifts" CDS 994336..994548 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523133; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="sporulation factor" /protein_id="NP_388875.1" /db_xref="EnsemblGenomes-Gn:BSU09940" /db_xref="EnsemblGenomes-Tr:CAB12834" /db_xref="GOA:O07520" /db_xref="InterPro:IPR025428" /db_xref="SubtiList:BG12988" /db_xref="UniProtKB/Swiss-Prot:O07520" /translation="MLFFPWWVYLCIVGIIFSAYKLVAAAKEEEKVDQAFIEKEGQIY MERMEKERERRSSQQHEEENQNHSIA*" /label="yhaL CDS" gene 994336..994548 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /label="yhaL gene" downshifts 994541 /Source="Nicolas_upshifts" /id="D533" /incds=0 /nref=8 /ntot=158 /MaxReadThrough="2.03283" /MaxDrop="6.60832" /score="62.1892984" /energy="-22" /TU="NA" /idTUdmin="U792" /TUdmin=5 /isTUend="TRUE" /label="downshifts" downshifts complement(994579) /Source="Nicolas_upshifts" /id="D534" /incds=0 /nref=97 /ntot=260 /MaxReadThrough="0.90997" /MaxDrop="9.00938" /score="52.3375501" /energy="-22" /TU="NA" /idTUdmin="U793" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(994589..995467) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12634326, 12682299, 14976191, 16516208, 25525259, 26711778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12634326, 12682299, 14976191, 16516208, 25525259, 26711778; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molecular chaperone lipoprotein" /protein_id="NP_388876.1" /db_xref="EnsemblGenomes-Gn:BSU09950" /db_xref="EnsemblGenomes-Tr:CAB12835" /db_xref="GOA:P24327" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR023059" /db_xref="InterPro:IPR027304" /db_xref="PDB:1ZK6" /db_xref="PDB:4WO7" /db_xref="SubtiList:BG10464" /db_xref="UniProtKB/Swiss-Prot:P24327" /translation="MKKIAIAAITATSILALSACSSGDKEVIAKTDAGDVTKGELYTN MKKTAGASVLTQLVQEKVLDKKYKVSDKEIDNKLKEYKTQLGDQYTALEKQYGKDYLK EQVKYELLTQKAAKDNIKVTDADIKEYWEGLKGKIRASHILVADKKTAEEVEKKLKKG EKFEDLAKEYSTDSSASKGGDLGWFAKEGQMDETFSKAAFKLKTGEVSDPVKTQYGYH IIKKTEERGKYDDMKKELKSEVLEQKLNDNAAVQEAVQKVMKKADIEVKDKDLKDTFN TSSTSNSTSSSSSNSK*" /label="prsA CDS" gene complement(994589..995467) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /label="prsA gene" downshifts complement(994777) /Source="Nicolas_upshifts" /id="D535" /incds=1 /nref=10 /ntot=127 /MaxReadThrough="7.54458" /MaxDrop="3.5906" /score="52.3375501" /energy="-22" /TU="U793" /idTUdmin="U793" /TUdmin="-187" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(995505..995524) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(995529) /Source="Nicolas_upshifts" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(995538..995545) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 995565..995574 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 995586 /Source="Nicolas_upshifts" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 995587..995606 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(995623..995637) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(995624) /Source="Nicolas_upshifts" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 995627..995713 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:20156992, 21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20156992, 21670523; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="spore assembly and germination protein" /protein_id="YP_003097699.1" /db_xref="EnsemblGenomes-Gn:BSU09958" /db_xref="EnsemblGenomes-Tr:CAX52587" /db_xref="GOA:C0H3Y2" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y2" /translation="MSGGYSNGFALLVVLFILLIIVGAAYIY*" /label="sscA CDS" gene 995627..995713 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /label="sscA gene" promotor_-35 complement(995646..995650) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 995714..995965 /Source="Nicolas_S_feature" /locus_tag="new_1071489_1071740" /HighExp="S8, S7, S6, BT, G/S, B36, Pyr, S5, B60, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S347" CDS 995838..995924 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore and germination protein" /protein_id="YP_009513948.1" /db_xref="EnsemblGenomes-Gn:BSU09959" /db_xref="EnsemblGenomes-Tr:CCQ48595" /db_xref="GOA:L8EBJ6" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8EBJ6" /translation="MGEVFAGGFALLVVLFILLIIIGASWLY*" /label="sscB CDS" gene 995838..995924 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /label="sscB gene" downshifts 995922 /Source="Nicolas_upshifts" /id="D536" /incds=0 /nref=28 /ntot=50 /MaxReadThrough="4.67734" /MaxDrop="4.7906" /score="14.3797211" /energy="-17.6" /TU="U794" /idTUdmin="U794" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" S_feature complement(995934..996196) /Source="Nicolas_S_feature" /locus_tag="new_1071709_1071971_c" /HighExp="LBGtran, LBGstat, LPhT, LBGexp, HPh, dia15, T0.30H, dia0, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S348" S_feature 995967..996450 /Source="Nicolas_S_feature" /locus_tag="new_1071742_1072225" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, Glucon, G/S, C90" /AntisenseName="yhaJ" /AntisenseCor="-0.22462434208606599" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S349" downshifts complement(995977) /Source="Nicolas_upshifts" /id="D537" /incds=0 /nref=153 /ntot=265 /MaxReadThrough="1.32339" /MaxDrop="6.55635" /score="34.7913848" /energy="-17.6" /TU="NA" /idTUdmin="U796" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(996189..996208) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(996196) /Source="Nicolas_upshifts" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(996198..996266) /Source="Nicolas_S_feature" /locus_tag="new_1071973_1072041_c" /HighExp="Paraq, G180, C30, LBGexp, Oxctl, G135, Lbexp, Heat, G150, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29568499999999998" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S350" promotor_-35 complement(996222..996227) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(996267..996785) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009, 21670523, 25651892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme" /protein_id="NP_388878.2" /db_xref="EnsemblGenomes-Gn:BSU09965" /db_xref="EnsemblGenomes-Tr:CAB12837" /db_xref="GOA:O07518" /db_xref="InterPro:IPR021683" /db_xref="SubtiList:BG12986" /db_xref="UniProtKB/Swiss-Prot:O07518" /translation="MNCWKTINLMKDYGAVRIILTAVCFMILVFISTFLAFELLRPGT SLSDEYVSLFGGLLVVILFVHKVIHVLPIICKKRKIEKKFYILRMRTWKRIPKTTMLI SLVSPFLLITPVLFYAALAFPNHAHYFCMISGIHAGYCLPDFLLALKLIKAPKTAFID QEADGLDILVEK*" /label="yhaJ CDS" gene complement(996267..996785) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /label="yhaJ gene" promotor_-35 996572..996580 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 996592..996610 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 996605 /Source="Nicolas_upshifts" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(996816..996835) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(996834) /Source="Nicolas_upshifts" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(996851..996857) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 996934..996937 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 996952..996971 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 996957 /Source="Nicolas_upshifts" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="upshifts" CDS 996993..997334 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388879.1" /db_xref="EnsemblGenomes-Gn:BSU09980" /db_xref="EnsemblGenomes-Tr:CAB12838" /db_xref="InterPro:IPR015058" /db_xref="InterPro:IPR035945" /db_xref="PDB:1SED" /db_xref="SubtiList:BG12985" /db_xref="UniProtKB/Swiss-Prot:O07517" /translation="MDSMDHRIERLEYYIQLLVKTVDMDRYPFYALLIDKGLSKEEGE AVMRICDELSEELATQKAQGFVTFDKLLALFAGQLNEKLDVHETIFALYEQGLYQELM EVFIDIMKHFD*" /label="yhaI CDS" gene 996993..997334 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /label="yhaI gene" S_feature complement(997188..997330) /Source="Nicolas_S_feature" /locus_tag="new_1072963_1073105_c" /HighExp="BC, S1, Sw, S2, S3, S8, S5, S4, S6, S7" /AntisenseName="yhaI" /AntisenseCor="5.4889858269512502E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S351" downshifts complement(997231) /Source="Nicolas_upshifts" /id="D538" /incds=1 /nref=39 /ntot=209 /MaxReadThrough="2.89899" /MaxDrop="4.77791" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(997331..997942) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of extracellular protease production, sporulation and bacilysin production (MarR family)" /protein_id="NP_388880.1" /db_xref="EnsemblGenomes-Gn:BSU09990" /db_xref="EnsemblGenomes-Tr:CAB12839" /db_xref="GOA:P11065" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR023488" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FXA" /db_xref="SubtiList:BG10659" /db_xref="UniProtKB/Swiss-Prot:P11065" /translation="MNRVEPPYDVKEALVFTQKMAQLSKALWKSIEKDWQQWLKPYDL NINEHHILWIAYQLNGASISEIAKFGVMHVSTAFNFSKKLEERGYLRFSKRLNDKRNT YVQLTEEGTEVFWSLLEEFDPTRNAVFKGSQPLYHLFGKFPEVAEMMCMIRHIYGDDF MEIFETSLTNIDNDFESVNGKLKKKAKDSAADEPAEELEPVNS*" /label="scoC CDS" gene complement(997331..997942) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /label="scoC gene" S_feature 997335..998100 /Source="Nicolas_S_feature" /locus_tag="new_1073110_1073875" /HighExp="Lbstat, Etha, T0.30H, Gly, M0t90, M40t90, M40t45, M0t45, H2O2, dia15" /AntisenseName="scoC" /AntisenseCor="-0.46322626361720198" /AntisenseRegPval="-15" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S352" downshifts complement(997407) /Source="Nicolas_upshifts" /id="D539" /incds=1 /nref=1 /ntot=81 /MaxReadThrough="5.81117" /MaxDrop="2.1632" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" promotor_-35 997938..997942 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 997950..997963 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 997962 /Source="Nicolas_upshifts" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(997967..997986) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-10" upshifts complement(997990) /Source="Nicolas_upshifts" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="upshifts" promotor_-35 complement(998001..998004) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-35" downshifts 998057 /Source="Nicolas_upshifts" /id="D540" /incds=0 /nref=1 /ntot=124 /MaxReadThrough="3.007" /MaxDrop="2.86547" /score="17.8486533" /energy="-7.1" /TU="U799,U800" /idTUdmin="U799" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(998120..998476) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11429463; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein; acid tolerance protein" /protein_id="NP_388881.1" /db_xref="EnsemblGenomes-Gn:BSU10000" /db_xref="EnsemblGenomes-Tr:CAB12840" /db_xref="GOA:O07516" /db_xref="InterPro:IPR024623" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12984" /db_xref="UniProtKB/Swiss-Prot:O07516" /translation="MASGRSLLTGLFVGGIIGGAAVLLTAPSSGKQLREKMKTNYDSF EETIKRLKSDGLALKDQLIKAAKESTDVIKDVGGELQTSIKKWQEEIKPHQQDLQKEI ADIEEKIRQLEKTLQN*" /label="yhaH CDS" gene complement(998120..998476) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /label="yhaH gene" downshifts complement(998124) /Source="Nicolas_upshifts" /id="D541" /incds=0 /nref=254 /ntot=287 /MaxReadThrough="1.65317" /MaxDrop="7.37381" /score="10.8990112" /energy="-7.9" /TU="NA" /idTUdmin="U804" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 998553..998558 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(998559..998578) /Source="Nicolas_upshift_promotors" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(998573) /Source="Nicolas_upshifts" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 998574..998592 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 998574 /Source="Nicolas_upshifts" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(998575..998838) /Source="Nicolas_S_feature" /locus_tag="new_1074350_1074613_c" /HighExp="Etha, Salt, HiTm, Heat, Diami, Sw, Gly, S1, MG 10, MG 60" /AntisenseName="yhzF" /AntisenseCor="-0.69425315975357205" /AntisenseRegPval="-39.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S353" CDS 998606..998797 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="membrane protein of unknown function" /protein_id="YP_003097700.1" /db_xref="EnsemblGenomes-Gn:BSU10009" /db_xref="EnsemblGenomes-Tr:CAX52588" /db_xref="GOA:C0H3Y3" /db_xref="UniProtKB/Swiss-Prot:C0H3Y3" /translation="MSVFLIVLSCITLAFASGAVYYIKLLSQAASYPPKRVIRQKALV CSTGTAFTLCLIFFTKLLA*" /label="yhzF CDS" gene 998606..998797 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /label="yhzF gene" S_feature 998798..1000233 /Source="Nicolas_S_feature" /locus_tag="new_1074573_1076008" /HighExp="S3, S8, S4, S6, S7, T5.0H, C30, S5, T4.0H, T3.30H" /AntisenseName="trpP" /AntisenseCor="-0.20038256384636899" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S354" CDS complement(998871..999389) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735881, 14702295, 15849754, 16850406, 16879415, 17114263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735881, 14702295, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="tryptophan transporter or sensor" /protein_id="NP_388882.2" /db_xref="EnsemblGenomes-Gn:BSU10010" /db_xref="EnsemblGenomes-Tr:CAB12841" /db_xref="GOA:O07515" /db_xref="InterPro:IPR031360" /db_xref="SubtiList:BG12983" /db_xref="UniProtKB/Swiss-Prot:O07515" /translation="MKTKELVIMALFAAIGAALHSIIPPFLGGMKPDMMLIMMFMGIL LFPRVQNVLVIGIVTGIISALTTAFPAGQIPNIIDKPVSAFLFFSLFLLFRKSRKTGA AAVLTVIGTILSGIVFLSSALLIVGLPGGFAALFAAVVLPAAVLNTISMIIIYPIVQT ILRRSSFMEAAK*" /label="trpP CDS" gene complement(998871..999389) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /label="trpP gene" downshifts complement(998883) /Source="Nicolas_upshifts" /id="D542" /incds=0 /nref=105 /ntot=253 /MaxReadThrough="6.00956" /MaxDrop="4.62812" /score="24.5949542" /energy="-12.8" /TU="U804,U805,U806" /idTUdmin="U804" /TUdmin="-750" /isTUend="FALSE" /label="downshifts" S_feature complement(999390..999477) /Source="Nicolas_S_feature" /locus_tag="new_1075165_1075252_c" /HighExp="C90, B60, S1, GM 15, MG 45, MG-0.2, Etha, Lbtran, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S355" promotor_-10 complement(999469..999488) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(999477) /Source="Nicolas_upshifts" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(999502..999509) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(999514..1000593) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /EC_number="2.6.1.52" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4337849, 16233211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4337849, 16233211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine aminotransferase" /protein_id="NP_388883.1" /db_xref="EnsemblGenomes-Gn:BSU10020" /db_xref="EnsemblGenomes-Tr:CAB12842" /db_xref="GOA:P80862" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR022278" /db_xref="SubtiList:BG12673" /db_xref="UniProtKB/Swiss-Prot:P80862" /translation="MERTTNFNAGPAALPLEVLQKAQKEFIDFNESGMSVMELSHRSK EYEAVHQKAKSLLIELMGIPEDYDILFLQGGASLQFSMLPMNFLTPEKTAHFVMTGAW SEKALAETKLFGNTSITATSETDNYSYIPEVDLTDVKDGAYLHITSNNTIFGTQWQEF PNSPIPLVADMSSDILSRKIDVSKFDVIYGGAQKNLGPSGVTVVIMKKSWLQNENANV PKILKYSTHVKADSLYNTPPTFAIYMLSLVLEWLKENGGVEAVEQRNEQKAQVLYSCI DESNGFYKGHARKDSRSRMNVTFTLRDDELTKTFVQKAKDAKMIGLGGHRSVGGCRAS IYNAVSLEDCEKLAAFMKKFQQENE*" /label="serC CDS" gene complement(999514..1000593) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /label="serC gene" misc_feature complement(1000632..1000651) /Source="Nicolas_upshift_promotors" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1000643) /Source="Nicolas_upshifts" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1000645..1000726) /Source="Nicolas_S_feature" /locus_tag="new_1076420_1076501_c" /HighExp="Etha, dia15, H2O2, LBGtran, G135, G180, dia5, G150, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S356" CDS complement(1000740..1001177) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /EC_number="3.6.1.29" /EC_number="3.6.1.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579061, 15703176, 16934294, 17217311, 26181368, 28516732; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous Hit-family phosphohydrolase, adenosine phosphoramidase" /protein_id="NP_388884.1" /db_xref="EnsemblGenomes-Gn:BSU10030" /db_xref="EnsemblGenomes-Tr:CAB12843" /db_xref="GOA:O07513" /db_xref="InterPro:IPR001310" /db_xref="InterPro:IPR011146" /db_xref="InterPro:IPR019808" /db_xref="InterPro:IPR036265" /db_xref="PDB:1Y23" /db_xref="SubtiList:BG12607" /db_xref="UniProtKB/Swiss-Prot:O07513" /translation="MHCAENCIFCKIIAGDIPSAKVYEDEHVLAFLDISQVTKGHTLV IPKTHIENVYEFTDELAKQYFHAVPKIARAIRDEFEPIGLNTLNNNGEKAGQSVFHYH MHIIPRYGKGDGFGAVWKTHADDYKPEDLQNISSSIAKRLASS*" /label="hinT CDS" gene complement(1000740..1001177) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /label="hinT gene" downshifts complement(1000771) /Source="Nicolas_upshifts" /id="D543" /incds=0 /nref=187 /ntot=248 /MaxReadThrough="4.31506" /MaxDrop="5.61862" /score="-0.366845751" /energy="-8.6" /TU="U806" /idTUdmin="U807" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1001210..1001229) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1001224) /Source="Nicolas_upshifts" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" downshifts 1001227 /Source="Nicolas_upshifts" /id="D544" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.3752" /MaxDrop="3.02008" /score="-3.56654132" /energy="-13.3" /TU="NA" /idTUdmin="U803" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(1001243..1001250) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1001249..1001545) /Source="Nicolas_S_feature" /locus_tag="new_1077024_1077320_c" /HighExp="S7, S8, S6, S5, BT, ferm, nit, G/S, S4, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S357" downshifts complement(1001292) /Source="Nicolas_upshifts" /id="D545" /incds=0 /nref=40 /ntot=72 /MaxReadThrough="3.07347" /MaxDrop="7.69075" /score="9.88617558" /energy="-14.2" /TU="U807" /idTUdmin="U807" /TUdmin="-517" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1001543..1001554) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1001549) /Source="Nicolas_upshifts" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1001569..1001575) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1001605..1001612 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1001626..1001645 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1001635 /Source="Nicolas_upshifts" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="upshifts" CDS 1001665..1002408 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 11807061, 18599827, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 11807061, 18599827, 26735940; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein)" /protein_id="NP_388885.1" /db_xref="EnsemblGenomes-Gn:BSU10040" /db_xref="EnsemblGenomes-Tr:CAB12844" /db_xref="GOA:P55339" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11516" /db_xref="UniProtKB/Swiss-Prot:P55339" /translation="MSLLSVKDLTGGYTRNPVLKNVSFTLEPNQIVGLIGLNGAGKST TIRHIIGLMDPHKGSIELNGKTFAEDPEGYRSQFTYIPETPVLYEELTLMEHLELTAM AYGLSKETMEKRLPPLLKEFRMEKRLKWFPAHFSKGMKQKVMIMCAFLAEPALYIIDE PFLGLDPLAINALLERMNEAKKGGASVLMSTHILATAERYCDSFIILHNGEVRARGTL SELREQFGMKDAALDDLYLELTKEDAGHE*" /label="ecsA CDS" gene 1001665..1002408 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /label="ecsA gene" CDS 1002401..1003627 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease subunit)" /protein_id="NP_388886.1" /db_xref="EnsemblGenomes-Gn:BSU10050" /db_xref="EnsemblGenomes-Tr:CAB12845" /db_xref="GOA:P55340" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG11517" /db_xref="UniProtKB/Swiss-Prot:P55340" /translation="MNNMLDIWQSRLQEHIKETRTYMKYMLNDHLVIVLIFFLAGAAS WYSKWIRDIPAHFPSFWVMAVLFSLVLTSSYVRTLLKEADLVFLLPLEAKMEPYLKQA FVYSYVSQLFPLIALSIVAMPLYFAVTPGASLVSYAAVFVQLLLLKAWNQVMEWRTTF QNDRSMKRMDVIIRFAANTLVLYFVFQSVYMYALLVYVIMAVLYLYMSSAAKRKTFKW ESHIESELRRKQRFYRIANLFTDVPHLRKQAKRRAYLDFLLRLVPFEQRKTFAYMFTR AFLRSSDYLGILVRLTIVFALIIMYVSASPLIAAVLTVFAIFITGIQLLPLFGHFDHL ALQELYPVQKETKLKSYFSLLKTALSIQALLMSVASAYAAGLTGFLYALIGSAVLIFV VLPAYMTTRLKKHGKL*" /label="ecsB CDS" gene 1002401..1003627 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /label="ecsB gene" promotor_-10 complement(1002960..1002978) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1002975) /Source="Nicolas_upshifts" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1002994..1002999) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1003647..1004357 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8581172, 10027970; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388887.1" /db_xref="EnsemblGenomes-Gn:BSU10060" /db_xref="EnsemblGenomes-Tr:CAB12846" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG11518" /db_xref="UniProtKB/Swiss-Prot:P55341" /translation="MTDNQLLMQEALEWKMHFLRKDSMFERFSKRVQTKVNERIPEKI HTVVTESVKKMVEATMAGSNIITYKKDTSALSLSEKNELAKKTIVSYQKVAAAEGVGT GAGGIFLSIADFPLLLSIKMKCLFTLSSIYGFDVKDAQERIFLLLVFQLAFSSDDGRK SLFSVIENWETEKKSIDWRVFQQEYRDYIDVVKLFQLLPGVGAAVGGIANYKLLAQLG ETARHVFHLRILKETAGE*" /label="ecsC CDS" gene 1003647..1004357 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /label="ecsC gene" downshifts 1004321 /Source="Nicolas_upshifts" /id="D546" /incds=0 /nref=78 /ntot=231 /MaxReadThrough="1.36097" /MaxDrop="4.78417" /score="28.5337351" /energy="-14.6" /TU="NA" /idTUdmin="U808" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(1004375..1005565) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /EC_number="3.5.1.-" /experiment="publication(s) with functional evidences, PMID:23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl amino acid acetylase, promiscuous activity" /protein_id="NP_388888.2" /db_xref="EnsemblGenomes-Gn:BSU10070" /db_xref="EnsemblGenomes-Tr:CAB12847" /db_xref="GOA:O07598" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12982" /db_xref="UniProtKB/Swiss-Prot:O07598" /translation="MSISTLQKEINKQLDGCFEEMVEIRRHFHMYPELSFQEEKTAAF IASYYESLGVPIRTNVGGRGVLANIEGSEPGPTVALRADFDALPIQDEKDVPYASKVP GVMHACGHDGHTAALLAVAKVLHQNRHELKGTFVMIHQHAEEYYPGGAKPMIDDGCLE NTDVIFGTHLWATEPLGTILCRPGAVMAAADRFTIKVFGKGGHGAHPHDTKDAVLIGS QIVSSLQHIVSRKVNPIQSAVISTGSFIADNPFNVIADQAVLIGTARSFDENVRDILE KEIEAVVKGICSMHGASYEYTYEQGYPAVVNHPAETNHLVSTAKNTEGVQQVIDGEPQ MGGEDFAYYLQNVKGTFFFTGAAPEQPERVYSHHHPKFDINEKAMLTAAKVLAGAAIT YHQL*" /label="sndC CDS" gene complement(1004375..1005565) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /label="sndC gene" downshifts complement(1004385) /Source="Nicolas_upshifts" /id="D547" /incds=0 /nref=11 /ntot=162 /MaxReadThrough="3.12546" /MaxDrop="4.15559" /score="-4.78420642" /energy="-14.6" /TU="U810" /idTUdmin="U811" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(1004450) /Source="Nicolas_upshifts" /id="D548" /incds=1 /nref=25 /ntot=206 /MaxReadThrough="4.92378" /MaxDrop="3.21645" /score="-4.78420642" /energy="-14.6" /TU="U810,U811" /idTUdmin="U811" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1005589..1005608) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1005610) /Source="Nicolas_upshifts" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1005622..1005627) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1005638..1007029) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 12107147; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388889.1" /db_xref="EnsemblGenomes-Gn:BSU10080" /db_xref="EnsemblGenomes-Tr:CAB12848" /db_xref="GOA:O07599" /db_xref="SubtiList:BG13047" /db_xref="UniProtKB/Swiss-Prot:O07599" /translation="MMEVGILPVHVLYVFFIGAIILFMLLRKDTTFISLFGIFIISLW ASHSLSASVSSLFHSFIYAAGELLPTIFIICFIVSMSDLLTKTGINEAMISPFASLVR GPVTAYWLIGGLMFAISLFFWPSPGVALIGAVLLPAAARAGLTPLAAAMAMNLFGHGF ALSGDFVIQAAPKLTADAAGIPVGDVVSASIPLVLIMGVTTTTAAFIMIQRERKKQEH PTSFSPVLSGEQDNSLYLPKRLRSILAFLIPLAFLADIACMLLFNLQGNDATALIGGS AICILFTVHFFVYKHKGLEKITGYFIDGFKFGFKVFGPVIPIAAFFYLGDSGYESILG TSLPKGSHGIVNDLGIALSHMMPMSKELAATALTAAGAITGLDGSGFSGISLAGSIAK LFSSALHADPAILTALGQISAIWVGGGTLVPWALIPAAAICKVDPFELARKNFIPVAI GLLVTTLAAVMML*" /label="yhfA CDS" gene complement(1005638..1007029) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /label="yhfA gene" promotor_-10 complement(1007040..1007059) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1007045) /Source="Nicolas_upshifts" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1007072..1007081) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1007095..1007409) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388890.1" /db_xref="EnsemblGenomes-Gn:BSU10090" /db_xref="EnsemblGenomes-Tr:CAB12849" /db_xref="SubtiList:BG10426" /db_xref="UniProtKB/Swiss-Prot:P38048" /translation="MKHTCPVCGFKDWLNRHMIMKAIILMKSARAAVFSSDLMSTRCS TRITHIEPSESIIAYRKNWLAEGCVIFSPECFPKHLQKANRGLRHHLIEQLKQINVHL PS*" /label="yhgB CDS" gene complement(1007095..1007409) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /label="yhgB gene" CDS complement(1007454..1007954) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /EC_number="1.14.99.48" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21873409, 22531134, 24582752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21873409, 22531134, 24582752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388891.1" /db_xref="EnsemblGenomes-Gn:BSU10100" /db_xref="EnsemblGenomes-Tr:CAB12850" /db_xref="GOA:P38049" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:4OZ5" /db_xref="SubtiList:BG10427" /db_xref="UniProtKB/Swiss-Prot:P38049" /translation="MKVYITYGTADFLKTIVQKHPSENILLMQGQENAILIHETNGDT VFQAPHAYEVIDQVGEIKHPGFAVLNNIAVTQEGRPLFENRFKNRAGKVENEPGFEAI RVLRPLDSDTYVILTLWETESAFQDWQQSGSYKEAHKKRDTSAGIDTTSIFSRPSYVT TYFAVE*" /label="hmoB CDS" gene complement(1007454..1007954) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /label="hmoB gene" downshifts complement(1007481) /Source="Nicolas_upshifts" /id="D549" /incds=0 /nref=145 /ntot=254 /MaxReadThrough="3.45185" /MaxDrop="5.6374" /score="15.5142908" /energy="-14.8" /TU="U812" /idTUdmin="U812" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1007967..1007986) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1007969..1007973 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1007988) /Source="Nicolas_upshifts" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1007989..1008008 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1007990 /Source="Nicolas_upshifts" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1008003..1008004) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1008021..1008027 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1008042..1008053 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1008047 /Source="Nicolas_upshifts" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="upshifts" CDS 1008076..1010220 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8335642, 11567005, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8335642, 11567005, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2C (1F class) required for spore germination" /protein_id="NP_388892.2" /db_xref="EnsemblGenomes-Gn:BSU10110" /db_xref="EnsemblGenomes-Tr:CAB12851" /db_xref="GOA:P38050" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10428" /db_xref="UniProtKB/Swiss-Prot:P38050" /translation="MFKIKKKKLFIPIIILVLTAFLALIGYISIIFLGHYVIDEKKLI LHASSKIVDQNGDEVASLYTENREPVSINEIPKQVREAFIAVEDKRFYEHHGIDAKSV GRAVYRDILAGGKVEGGSTITQQLAKNIFLTHDKTFLRKTKEVIIAINLERDYSKDKL LEMYLNQLYFGHGVYGIQAASHYYFNKEVKDLTVSEGAVLAAIPKAPSTYSPILHPDK NKERRDTILGMMNDQGYISAKEAVTAQGRTLGLHVKKQSETPWFDSYIDLVIKEAEDK YSISGEQLLQGGYTIKVPLDSKLQKTAYQVMKEGSYYPGTDQNAEGSAVFINNKTGGV EAAIGGRDYTSKGYNRVTAVRQPGSTFKPLAVYGPAMQEKKFKPYSLLKDELQSYGDY TPKNYDSRYEGEVTMSDAITYSKNAPAVWTLNEIGVETGKSYLKANGIDIPDEGLALA LGGLEKGVSPLQLAGAFHTFAANGTYTEPFFISSIIDEDGETIADHKEEGKRVFSKQT SWNMTRMLQQVVKKGTATSGTYHGDLAGKTGSTSYTGVSGATKDAWFAGYTPKITGAV WMGYDKTDQNHYLKAGSSYPTRLFKDILTQAGETGHVFTKPKNVKELESPIELKPVKT LTADYTFKAAGLFTIELKWDAQEDDRAVYRIYVNKDGEETLLDSVEGKGSYEIPYANL FSGASYKIVPYNTQTKREGEGTDYVQPKLFSS*" /label="pbpF CDS" gene 1008076..1010220 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /label="pbpF gene" promotor_-10 complement(1008120..1008131) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1008123) /Source="Nicolas_upshifts" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1008145..1008151) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1010257..1010263 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1010277..1010296 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1010287 /Source="Nicolas_upshifts" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" CDS 1010342..1011403 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /EC_number="4.1.1.37" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 17122346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 17122346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III decarboxylase" /protein_id="NP_388893.1" /db_xref="EnsemblGenomes-Gn:BSU10120" /db_xref="EnsemblGenomes-Tr:CAB12852" /db_xref="GOA:P32395" /db_xref="InterPro:IPR000257" /db_xref="InterPro:IPR006361" /db_xref="PDB:2INF" /db_xref="SubtiList:BG10429" /db_xref="UniProtKB/Swiss-Prot:P32395" /translation="MSKRETFNETFLKAARGEKADHTPVWYMRQAGRSQPEYRKLKEK YGLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIMTPLPSIGVDVEIKNGIGPVIDQ PIRSLADIEKLGQIDPEQDVPYVLETIKLLVNEQLNVPLIGFSGAPFTLASYMIEGGP SKNYNKTKAFMYSMPDAWNLLMSKLADMIIVYVKAQIEAGAKAIQIFDSWVGALNQAD YRTYIKPVMNRIFSELAKENVPLIMFGVGASHLAGDWHDLPLDVVGLDWRLGIDEARS KGITKTVQGNLDPSILLAPWEVIEQKTKEILDQGMESDGFIFNLGHGVFPDVSPEVLK KLTAFVHEYSQNKKMGQYS*" /label="hemE CDS" gene 1010342..1011403 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /label="hemE gene" CDS 1011475..1012407 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /EC_number="4.99.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferrochelatase" /protein_id="NP_388894.1" /db_xref="EnsemblGenomes-Gn:BSU10130" /db_xref="EnsemblGenomes-Tr:CAB12853" /db_xref="GOA:P32396" /db_xref="InterPro:IPR001015" /db_xref="InterPro:IPR019772" /db_xref="InterPro:IPR033644" /db_xref="InterPro:IPR033659" /db_xref="PDB:1AK1" /db_xref="PDB:1C1H" /db_xref="PDB:1C9E" /db_xref="PDB:1DOZ" /db_xref="PDB:1FJI" /db_xref="PDB:1LD3" /db_xref="PDB:1N0I" /db_xref="PDB:2AC2" /db_xref="PDB:2AC4" /db_xref="PDB:2H1V" /db_xref="PDB:2H1W" /db_xref="PDB:2HK6" /db_xref="PDB:2Q2N" /db_xref="PDB:2Q2O" /db_xref="PDB:2Q3J" /db_xref="PDB:3GOQ" /db_xref="PDB:3M4Z" /db_xref="SubtiList:BG10430" /db_xref="UniProtKB/Swiss-Prot:P32396" /translation="MSRKKMGLLVMAYGTPYKEEDIERYYTHIRRGRKPEPEMLQDLK DRYEAIGGISPLAQITEQQAHNLEQHLNEIQDEITFKAYIGLKHIEPFIEDAVAEMHK DGITEAVSIVLAPHFSTFSVQSYNKRAKEEAEKLGGLTITSVESWYDEPKFVTYWVDR VKETYASMPEDERENAMLIVSAHSLPEKIKEFGDPYPDQLHESAKLIAEGAGVSEYAV GWQSEGNTPDPWLGPDVQDLTRDLFEQKGYQAFVYVPVGFVADHLEVLYDNDYECKVV TDDIGASYYRPEMPNAKPEFIDALATVVLKKLGR*" /label="hemH CDS" gene 1011475..1012407 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /label="hemH gene" CDS 1012422..1013834 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /EC_number="1.3.3.4" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9217019, 9784236, 10498703, 20543190" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9217019, 9784236, 10498703, 20543190; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous protoporphyrinogen IX and coproporphyrinogen III oxidase" /protein_id="NP_388895.1" /db_xref="EnsemblGenomes-Gn:BSU10140" /db_xref="EnsemblGenomes-Tr:CAB12854" /db_xref="GOA:P32397" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR004572" /db_xref="InterPro:IPR036188" /db_xref="PDB:3I6D" /db_xref="SubtiList:BG10431" /db_xref="UniProtKB/Swiss-Prot:P32397" /translation="MSDGKKHVVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASP RVGGKIQTVKKDGYIIERGPDSFLERKKSAPQLVKDLGLEHLLVNNATGQSYVLVNRT LHPMPKGAVMGIPTKIAPFVSTGLFSLSGKARAAMDFILPASKTKDDQSLGEFFRRRV GDEVVENLIEPLLSGIYAGDIDKLSLMSTFPQFYQTEQKHRSLILGMKKTRPQGSGQQ LTAKKQGQFQTLSTGLQTLVEEIEKQLKLTKVYKGTKVTKLSHSGSCYSLELDNGVTL DADSVIVTAPHKAAAGMLSELPAISHLKNMHSTSVANVALGFPEGSVQMEHEGTGFVI SRNSDFAITACTWTNKKWPHAAPEGKTLLRAYVGKAGDESIVDLSDNDIINIVLEDLK KVMNINGEPEMTCVTRWHESMPQYHVGHKQRIKELREALASAYPGVYMTGASFEGVGI PDCIDQGKAAVSDALTYLFS*" /label="hemY CDS" gene 1012422..1013834 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /label="hemY gene" downshifts 1012425 /Source="Nicolas_upshifts" /id="D550" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="7.68191" /MaxDrop="2.667" /score="28.7532434" /energy="-11.6" /TU="U813,U816" /idTUdmin="U814" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1013811 /Source="Nicolas_upshifts" /id="D551" /incds=0 /nref=195 /ntot=254 /MaxReadThrough="2.9859" /MaxDrop="6.7703" /score="28.7532434" /energy="-11.6" /TU="NA" /idTUdmin="U813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1013895..1013902 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1013916..1013935 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1013921 /Source="Nicolas_upshifts" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" CDS 1013980..1014555 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15944459, 23695570; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown target" /protein_id="NP_388896.1" /db_xref="EnsemblGenomes-Gn:BSU10150" /db_xref="EnsemblGenomes-Tr:CAB12855" /db_xref="GOA:P32398" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10432" /db_xref="UniProtKB/Swiss-Prot:P32398" /translation="MSIDRKKLILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTF FKNKEELFDEIFTTLLKEMKQKADEAMEPSLPFHENVHRALFAILEFRKTHQLTIKIF QENAEIGTMAVQEVIQKMERSILSYIKSKIEDGIKSGAIKPCDPELTAFVMLKLYIAL IFDWEKQHPPLDKETIAGLLELYVVKGLSAN*" /label="yhgD CDS" gene 1013980..1014555 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /label="yhgD gene" promotor_-35 1014299..1014302 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1014317 /Source="Nicolas_upshifts" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1014319..1014338 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1014556..1014625 /Source="Nicolas_S_feature" /locus_tag="new_1090331_1090400" /HighExp="G135, G150, G180, BI, Salt, Etha, Cold, Heat, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.731, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S358" CDS 1014626..1016953 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576783; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting protein" /protein_id="NP_388897.1" /db_xref="EnsemblGenomes-Gn:BSU10160" /db_xref="EnsemblGenomes-Tr:CAB12856" /db_xref="GOA:P32399" /db_xref="InterPro:IPR017500" /db_xref="InterPro:IPR017501" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR023908" /db_xref="SubtiList:BG10433" /db_xref="UniProtKB/Swiss-Prot:P32399" /translation="MNTIRSQWKDIVTSKKLLIPIIAILFVPLIYSGVFLKAYWDPYG TVDQLPVVVVNQDKGATYEGEKLQIGDDLVKELKDNNNFDWHFSNDLDQSLKDLLNQK YYLVVEIPEDFSKNASTVLDKNPKKLDLKYHTNAGSNYVGATIGEKAIDKLKASVSKE VTEQYTKVIFDNFKDIAKGLSDASSGAKKIDDGTKDAKNGSAQLKENLAKLKESTATI SDKTAQLADGAAQVTSGIQSLDSSLGKFQDSSNQIYDKSSQLAAGSGELTSKMNELLA GLQNVQKGTPNLTNGLDQLNSKVQEGSEKAAKAEKIINALDLTKLETAVNNLEKSETA MKEFKKQLTDFENSLKNRDQAFKNVINSSDFLTAEQKSQLINSVEKKLPQVDAPDFDQ ILSQLPTADQLPDIATIKSSLEDVKAQVAQVKAMPEATSKLYNGAKTIQDAIDRLTEG ADKIYNGSQKLTDGQTKLTAGIGEYNKQFAKAKAGSEQLVTGSSQVSGGLFKLLDGSK QVQSGSSKLADGSASLDTGLGKLLDGTGELSSKLKDAADQTGDIDADDQTYGMFADPV KTKDDAIHSVPNYGTGLTPYILSMGLYVGGIMLTVVFPLKEASGRPRNGFEWFFSKFN VMMLVGIIQSLIVATVLLLGIGLEVESTWRFYVFTIITSLAFLAIIQFLATTMGNPGR FIAVIILVLQLGASGGTFPLELLPNFYQVIHGALPMTYSINGFRAVISNGDFGYMWQM AGVLIGIALVMIALSITYFTMLSRKEETSEEQPAS*" /label="yhgE CDS" gene 1014626..1016953 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /label="yhgE gene" downshifts 1016935 /Source="Nicolas_upshifts" /id="D552" /incds=0 /nref=65 /ntot=211 /MaxReadThrough="0.57274" /MaxDrop="5.58483" /score="-4.79013797" /energy="-7.3" /TU="NA" /idTUdmin="U817" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1016995..1017972) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 21383089, 21542858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 21383089, 21542858; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 2" /protein_id="NP_388898.1" /db_xref="EnsemblGenomes-Gn:BSU10170" /db_xref="EnsemblGenomes-Tr:CAB12857" /db_xref="GOA:O07600" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13048" /db_xref="UniProtKB/Swiss-Prot:O07600" /translation="MSKAKITAIGTYAPSRRLTNADLEKIVDTSDEWIVQRTGMRERR IADEHQFTSDLCIEAVKNLKSRYKGTLDDVDMILVATTTSDYAFPSTACRVQEYFGWE STGALDINATCAGLTYGLHLANGLITSGLHQKILVIAGETLSKVTDYTDRTTCVLFGD AAGALLVERDEETPGFLASVQGTSGNGGDILYRAGLRNEINGVQLVGSGKMVQNGREV YKWAARTVPGEFERLLHKAGLSSDDLDWFVPHSANLRMIESICEKTPFPIEKTLTSVE HYGNTSSVSIVLALDLAVKAGKLKKDQIVLLFGFGGGLTYTGLLIKWGM*" /label="fabHB CDS" gene complement(1016995..1017972) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /label="fabHB gene" downshifts complement(1017008) /Source="Nicolas_upshifts" /id="D553" /incds=0 /nref=21 /ntot=217 /MaxReadThrough="1.99012" /MaxDrop="7.90433" /score="-9.17544275" /energy="-7.3" /TU="NA" /idTUdmin="U819" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1017986..1018005) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1018004) /Source="Nicolas_upshifts" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1018019..1018025) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1018031..1018039 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1018050..1018068 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1018057 /Source="Nicolas_upshifts" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 1018099..1018875 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388899.1" /db_xref="EnsemblGenomes-Gn:BSU10180" /db_xref="EnsemblGenomes-Tr:CAB12858" /db_xref="GOA:O07601" /db_xref="InterPro:IPR011397" /db_xref="SubtiList:BG13049" /db_xref="UniProtKB/Swiss-Prot:O07601" /translation="MVSQEAVVFLALSGAIAFLLPIGLIVWFKRKYGASLKVFFIGAL TFFVFAQLLEGGVHVYVLQVNEMTKEAMQHPLWYGIYGCLMAGIFEECGRYLMMRFFM KRHHTWADGLAFGAGHGGLEAILITGLSSISLIVYAFAINSGTFEQLLVNGDVKQALL PIQEQLLHTPSYEWMLGGIERISAIAVQIGLSLLVLYAVKNRRPLFLLYSILLHALFN VPAVLYQRGIIEHAAAVEIIVALIAALSVYWIVKAKRVFQ*" /label="yhfC CDS" gene 1018099..1018875 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /label="yhfC gene" S_feature complement(1018591..1019212) /Source="Nicolas_S_feature" /locus_tag="new_1094366_1094987_c" /HighExp="B36, BT, B60, Pyr, S8, G/S, G135, Mal, M/G, Glucon" /AntisenseName="yhfC" /AntisenseCor="-0.12937903461570099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="0.51248700000000003" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S359" S_feature 1018876..1019247 /Source="Nicolas_S_feature" /locus_tag="new_1094651_1095022" /HighExp="Lbstat, S2, M0t90, M40t90, HiOs, SMMPr, T-2.40H, Etha, Lbtran, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48518699999999998" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S360" promotor_-10 complement(1019190..1019209) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1019211) /Source="Nicolas_upshifts" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1019223..1019232) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1019225..1019232 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1019247..1019266 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1019249 /Source="Nicolas_upshifts" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 1019288..1020328 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15713475, 15743956; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminopeptidase" /protein_id="NP_388901.1" /db_xref="EnsemblGenomes-Gn:BSU10200" /db_xref="EnsemblGenomes-Tr:CAB12860" /db_xref="GOA:O07603" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13051" /db_xref="UniProtKB/Swiss-Prot:O07603" /translation="MTSVRKTMELIKELVSIPSPTGNTYEVINYIESLLKEWKVETVR NHKGGLIATLPGRDTSRHRMLTAHVDTLGAMVKEIKADGRLKIDLIGGFRYNSIEGEY CQIETASGKMYTGTILMHQTSVHVYKDAGKAERNQENMEIRLDEPVHCRKDTEELGIG VGDFVSFDPRVEITSSGFIKSRHLDDKASVALLLRLIHEIQTEDIELPYTTHFLISNN EEIGYGGNSNIPPETVEYLAVDMGAIGDGQATDEYSVSICVKDASGPYHYQLRKHLVQ LAEKHHIDYKLDIYPYYGSDASAAIKSGHDIVHGLIGPGIDASHAFERTHKSSLRHTA KLLYYYVQSPMV*" /label="yhfE CDS" gene 1019288..1020328 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /label="yhfE gene" CDS 1020341..1020748 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11157739, 14517985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding PUA-containing enzyme" /protein_id="NP_388902.1" /db_xref="EnsemblGenomes-Gn:BSU10210" /db_xref="EnsemblGenomes-Tr:CAB12861" /db_xref="InterPro:IPR007374" /db_xref="InterPro:IPR009326" /db_xref="InterPro:IPR015947" /db_xref="SubtiList:BG13052" /db_xref="UniProtKB/Swiss-Prot:O07604" /translation="MKIYKLKSTFGWEGDDGLGEQLIQQILAGEKSATCAPKSLYSKD ELRDVYQTAGQLVTVYDKHDNPRCNIKVTDVFETTFGAPDMRLVKGEGNGDRIEEFQE DHRMAWAELIKSGELELNEDTVLITELFVLVKD*" /label="yhfF CDS" gene 1020341..1020748 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /label="yhfF gene" downshifts 1020719 /Source="Nicolas_upshifts" /id="D554" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="0.87656" /MaxDrop="5.21108" /score="22.0862441" /energy="-20.3" /TU="U822" /idTUdmin="U822" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(1020785..1022074) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/sodium-glutamate (aspartate) symport permease" /protein_id="NP_388903.1" /db_xref="EnsemblGenomes-Gn:BSU10220" /db_xref="EnsemblGenomes-Tr:CAB12862" /db_xref="GOA:O07605" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12595" /db_xref="UniProtKB/Swiss-Prot:O07605" /translation="MKRIKFGLATQIFVGLILGVIVGVIWYGNPALPTYLQPIGDLFL RLIKMIVIPIVVSSLIIGVAGAGNGKQVGKLGFRTILYFEIITTFAIILGLALANIFH PGTGVNIHEAQKSDISQYVETEKEQSNKSVAETFLHIVPTNFFQSLVEGDLLAIICFT VLFALGISAIGERGKPVLAFFEGVSHAMFHVVNLVMKVAPFGVFALIGVTVSKFGLGS LISLGKLVGLVYVALAFFLIVIFGIVAKIAGISIFKFLAYMKDEILLAFSTSSSETVL PRIMEKMEKIGCPKGIVSFVIPIGYTFNLDGSVLYQSIAALFLAQVYGIDLTIWHQIT LVLVLMVTSKGMAAVPGTSFVVLLATLGTIGVPAEGLAFIAGVDRIMDMARTVVNLTG NALAAVVMSKWEGMFNPAKAETVMSQSKTEQNATISG*" /label="gltT CDS" gene complement(1020785..1022074) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /label="gltT gene" downshifts complement(1020815) /Source="Nicolas_upshifts" /id="D555" /incds=0 /nref=226 /ntot=280 /MaxReadThrough="2.99263" /MaxDrop="7.79183" /score="48.7726082" /energy="-21.9" /TU="U823" /idTUdmin="U824" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(1022075..1022175) /Source="Nicolas_S_feature" /locus_tag="new_1097850_1097950_c" /HighExp="C90, LoTm, LBGexp, Cold, UNK1, BC, dia5, Lbexp, S1, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S361" promotor_-10 complement(1022174..1022193) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1022175) /Source="Nicolas_upshifts" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1022177..1022313) /Source="Nicolas_S_feature" /locus_tag="new_1097952_1098088_c" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, T2.30H, T5.0H, Cold, T2.0H, S0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S362" promotor_-35 complement(1022208..1022214) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1022345..1022485) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388904.1" /db_xref="EnsemblGenomes-Gn:BSU10230" /db_xref="EnsemblGenomes-Tr:CAB12863" /db_xref="InterPro:IPR025432" /db_xref="SubtiList:BG13053" /db_xref="UniProtKB/Swiss-Prot:O07606" /translation="MVMLGKITEFFRNLPSKKCAECGKKIEEQHECYGNICNDCIKVN DL*" /label="yhfH CDS" gene complement(1022345..1022485) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /label="yhfH gene" downshifts complement(1022358) /Source="Nicolas_upshifts" /id="D556" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.70702" /MaxDrop="4.73949" /score="28.7665297" /energy="-13.6" /TU="U824" /idTUdmin="U824" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1022504..1022523) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1022523) /Source="Nicolas_upshifts" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1022536..1022543) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1022567..1022573 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1022587..1022606 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1022590 /Source="Nicolas_upshifts" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="upshifts" CDS 1022637..1023371 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388905.1" /db_xref="EnsemblGenomes-Gn:BSU10240" /db_xref="EnsemblGenomes-Tr:CAB12864" /db_xref="GOA:O07607" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13054" /db_xref="UniProtKB/Swiss-Prot:O07607" /translation="MKVTVIGCYGGFPAANEATSGYLFQSGDYSLLVDCGSAVLSKLF GYVPAEKLDAVVLSHYHHDHIADIGPLQFAKQVGSFLGKGEHTLPIYGHDADIEQFQK LTYKTHTKGIAYQPDQPLTAGPFTITFLKTIHPVTCYAMRITDGSHTVVYTADSSYQD SFIPFSKDADLLISECNFYADQDGTSAGHMNSLEAGRIAKEAGAGELLLTHLPHFGVH DNLRKEAKTVFNGEVNIAKSGFVWEG*" /label="yhfI CDS" gene 1022637..1023371 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /label="yhfI gene" CDS 1023384..1024379 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /EC_number="6.3.1.20" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoate-protein ligase" /protein_id="NP_388906.1" /db_xref="EnsemblGenomes-Gn:BSU10250" /db_xref="EnsemblGenomes-Tr:CAB12865" /db_xref="GOA:O07608" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004562" /db_xref="InterPro:IPR019491" /db_xref="SubtiList:BG13055" /db_xref="UniProtKB/Swiss-Prot:O07608" /translation="MLFIDNQNINDPRINLAIEEYCVKHLDPEQQYLLFYVNQPSIII GKNQNTIEEINTKYVEENGIIVVRRLSGGGAVYHDLGNLNFSFITKDDGDSFHNFKKF TEPVIQALHQLGVEAELSGRNDIVVDGRKISGNAQFATKGRIFSHGTLMFDSAIDHVV SALKVKKDKIESKGIKSIRSRVANISEFLDDKMTTEEFRSHLLRHIFNTNDVGNVPEY KLTEKDWETIHQISKERYQNWDWNYGRSPKFNLNHSKRYPVGSIDLHLEVKKGKIEDC KIFGDFFGVGDVSEIENLLVGKQYERSVIADVLEGVNLKHYFGNITKEDFLDLIY*" /label="lplJ CDS" gene 1023384..1024379 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /label="lplJ gene" CDS 1024444..1025088 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11790741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-binding epimerase / hydratase" /protein_id="NP_388907.1" /db_xref="EnsemblGenomes-Gn:BSU10260" /db_xref="EnsemblGenomes-Tr:CAB12866" /db_xref="GOA:O07609" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13056" /db_xref="UniProtKB/Swiss-Prot:O07609" /translation="MKVFLIGANGQIGQRLVSLFQDNPDHSIRAMVRKEEQKASLEAA GAEAVLANLEGSPEEIAAAAKGCDAIIFTAGSGGSTGYDKTLLVDLDGAAKAIEAAAI AGIKRFIMVSALQAHNRENWNEALKPYYVAKHYADKILEASGLTYTIIRPGGLRNEPG TGTVSAAKDLERGFISRDDVAKTVIASLDEKNTENRAFDLTEGDTPIAEALKKL*" /label="yhfK CDS" gene 1024444..1025088 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /label="yhfK gene" downshifts 1025076 /Source="Nicolas_upshifts" /id="D557" /incds=0 /nref=239 /ntot=258 /MaxReadThrough="0.56809" /MaxDrop="6.84076" /score="18.2092404" /energy="-10" /TU="NA" /idTUdmin="U825" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1025116..1025119 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1025134..1025153 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1025141 /Source="Nicolas_upshifts" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="upshifts" CDS 1025205..1026746 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long-chain fatty-acid-CoA ligase (degradative)" /protein_id="NP_388908.2" /db_xref="EnsemblGenomes-Gn:BSU10270" /db_xref="EnsemblGenomes-Tr:CAB12867" /db_xref="GOA:O07610" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13057" /db_xref="UniProtKB/Swiss-Prot:O07610" /translation="MNLVSKLEETASEKPDSIACRFKDHMMTYQELNEYIQRFADGLQ EAGMEKGDHLALLLGNSPDFIIAFFGALKAGIVVVPINPLYTPTEIGYMLTNGDVKAI VGVSQLLPLYESMHESLPKVELVILCQTGEAEPEAADPEVRMKMTTFAKILRPTSAAK QNQEPVPDDTAVILYTSGTTGKPKGAMLTHQNLYSNANDVAGYLGMDERDNVVCALPM FHVFCLTVCMNAPLMSGATVLIEPQFSPASVFKLVKQQQATIFAGVPTMYNYLFQHEN GKKDDFSSIRLCISGGASMPVALLTAFEEKFGVTILEGYGLSEASPVTCFNPFDRGRK PGSIGTSILHVENKVVDPLGRELPAHQVGELIVKGPNVMKGYYKMPMETEHALKDGWL YTGDLARRDEDGYFYIVDRKKDMIIVGGYNVYPREVEEVLYSHPDVKEAVVIGVPDPQ SGEAVKGYVVPKRSGVTEEDIMQHCEKHLAKYKRPAAITFLDDIPKNATGKMLRRALR DILPQ*" /label="lcfB CDS" gene 1025205..1026746 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /label="lcfB gene" downshifts 1026726 /Source="Nicolas_upshifts" /id="D558" /incds=0 /nref=5 /ntot=108 /MaxReadThrough="2.74134" /MaxDrop="3.72638" /score="15.3712924" /energy="-10.4" /TU="NA" /idTUdmin="U826" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1026785..1027180) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388909.1" /db_xref="EnsemblGenomes-Gn:BSU10280" /db_xref="EnsemblGenomes-Tr:CAB12868" /db_xref="SubtiList:BG13058" /db_xref="UniProtKB/Swiss-Prot:O07611" /translation="MKKIVAAIVVIGLVFIAFFYLYSRSGDVYQSVDADLITLSSSGQ EDIEIEKRQHVKDMLDIMNQGKQVKTEKTSAPDYEGTIKFHKDRYDSFRLWIDGSQQA VFLKDGTYYKLSKNDTKALLNIIKKEAKD*" /label="yhfM CDS" gene complement(1026785..1027180) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /label="yhfM gene" downshifts complement(1026802) /Source="Nicolas_upshifts" /id="D559" /incds=0 /nref=46 /ntot=89 /MaxReadThrough="0.75539" /MaxDrop="6.88759" /score="17.4775611" /energy="-10.4" /TU="NA" /idTUdmin="U827" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1027200..1027211) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1027204) /Source="Nicolas_upshifts" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1027226..1027232) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1027265..1027268 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1027276 /Source="Nicolas_upshifts" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1027283..1027302 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1027329..1028609 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /EC_number="3.4.24.84" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9015299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane metalloprotease" /protein_id="NP_388910.1" /db_xref="EnsemblGenomes-Gn:BSU10290" /db_xref="EnsemblGenomes-Tr:CAB12869" /db_xref="GOA:P40769" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR027057" /db_xref="InterPro:IPR032456" /db_xref="SubtiList:BG11029" /db_xref="UniProtKB/Swiss-Prot:P40769" /translation="MRKWIAAAGLAYVLYGLFFYWYFFLSGDSAIPEAVKGTQADPAS FMKPSELAVAEQYSNVKNFLFFIGVPLDWFLFFVLLVSGVSKKIKKWIEAAVPFRFLQ TVGFVFVLSLITTLVTLPLDWIGYQVSLDYNISTQTTASWAKDQVISFWISFPIFTLC VLVFYWLIKRHEKKWWLYAWLLTVPFSLFLFFIQPVIIDPLYNDFYPLKNKELESKIL ELADEANIPADHVYEVNMSEKTNALNAYVTGIGANKRIVLWDTTLNKLDDSEILFIMG HEMGHYVMKHVYIGLAGYLLVSLAGFYVIDKLYKRTVRLTRSMFHLEGRHDLAALPLL LLLFSVLSFAVTPFSNAVSRYQENKADQYGIELTENREAAVKTFQDLAVTGLSQVDPP VLVKIFRGSHPSIMERIQHAEKEENAPEHQDADK*" /label="yhfN CDS" gene 1027329..1028609 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /label="yhfN gene" promotor_-10 complement(1027756..1027775) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1027770) /Source="Nicolas_upshifts" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1027791..1027796) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1028596 /Source="Nicolas_upshifts" /id="D560" /incds=0 /nref=2 /ntot=57 /MaxReadThrough="3.82026" /MaxDrop="3.6342" /score="6.45541384" /energy="-12.7" /TU="U828" /idTUdmin="U828" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts complement(1028646) /Source="Nicolas_upshifts" /id="D561" /incds=0 /nref=129 /ntot=219 /MaxReadThrough="-0.11848" /MaxDrop="9.02627" /score="-6.76069514" /energy="-7.8" /TU="NA" /idTUdmin="U830" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1028648..1029793) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /EC_number="3.4.21.62" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine alkaline protease (Ca(2+)-dependent subtilisin E)" /protein_id="NP_388911.2" /db_xref="EnsemblGenomes-Gn:BSU10300" /db_xref="EnsemblGenomes-Tr:CAB12870" /db_xref="GOA:P04189" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="PDB:1SCJ" /db_xref="PDB:3WHI" /db_xref="SubtiList:BG10190" /db_xref="UniProtKB/Swiss-Prot:P04189" /translation="MRSKKLWISLLFALTLIFTMAFSNMSAQAAGKSSTEKKYIVGFK QTMSAMSSAKKKDVISEKGGKVQKQFKYVNAAAATLDEKAVKELKKDPSVAYVEEDHI AHEYAQSVPYGISQIKAPALHSQGYTGSNVKVAVIDSGIDSSHPDLNVRGGASFVPSE TNPYQDGSSHGTHVAGTIAALNNSIGVLGVAPSASLYAVKVLDSTGSGQYSWIINGIE WAISNNMDVINMSLGGPTGSTALKTVVDKAVSSGIVVAAAAGNEGSSGSTSTVGYPAK YPSTIAVGAVNSSNQRASFSSAGSELDVMAPGVSIQSTLPGGTYGAYNGTSMATPHVA GAAALILSKHPTWTNAQVRDRLESTATYLGNSFYYGKGLINVQAAAQ*" /label="aprE CDS" gene complement(1028648..1029793) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /label="aprE gene" S_feature complement(1029794..1029860) /Source="Nicolas_S_feature" /locus_tag="new_1105569_1105635_c" /HighExp="BC, T5.0H, LoTm, Sw, T4.0H, T3.30H, S1, T3.0H, S2, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S363" promotor_-10 complement(1029849..1029868) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1029866) /Source="Nicolas_upshifts" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1029884..1029888) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1030173..1030180 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-35" promotor_-10 1030195..1030214 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-10" upshifts 1030197 /Source="Nicolas_upshifts" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="upshifts" CDS 1030228..1030677 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /EC_number="2.3.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388912.1" /db_xref="EnsemblGenomes-Gn:BSU10310" /db_xref="EnsemblGenomes-Tr:CAB12871" /db_xref="GOA:O07614" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13059" /db_xref="UniProtKB/Swiss-Prot:O07614" /translation="MNIRQAKTSDAAAIAPLFNQYREFYRQASDLQGAEAFLKARLEN HESVILIAEENGEFIGFTQLYPTFSSVSMKRIYILNDLFVVPHARTKGAGGRLLSAAK DYAGQNGAKCLTLQTEHHNRKARSLYEQNGYEEDTGFVHYCLNVPAK*" /label="yhfO CDS" gene 1030228..1030677 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /label="yhfO gene" promotor_-35 1030693..1030700 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1030715..1030734 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1030722 /Source="Nicolas_upshifts" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1030749..1031741 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9643546, 12057962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388913.1" /db_xref="EnsemblGenomes-Gn:BSU10320" /db_xref="EnsemblGenomes-Tr:CAB12872" /db_xref="GOA:O07615" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014188" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="PDB:1TT7" /db_xref="PDB:1Y9E" /db_xref="SubtiList:BG13060" /db_xref="UniProtKB/Swiss-Prot:O07615" /translation="MSTLFQALQAEKNADDVSVHVKTISTEDLPKDGVLIKVAYSGIN YKDGLAGKAGGNIVREYPLILGIDAAGTVVSSNDPRFAEGDEVIATSYELGVSRDGGL SEYASVPGDWLVPLPQNLSLKEAMVYGTAGFTAALSVHRLEQNGLSPEKGSVLVTGAT GGVGGIAVSMLNKRGYDVVASTGNREAADYLKQLGASEVISREDVYDGTLKALSKQQW QGAVDPVGGKQLASLLSKIQYGGSVAVSGLTGGGEVPATVYPFILRGVSLLGIDSVYC PMDVRAAVWERMSSDLKPDQLLTIVDREVSLEETPGALKDILQNRIQGRVIVKL*" /label="yhfP CDS" gene 1030749..1031741 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /label="yhfP gene" downshifts 1031742 /Source="Nicolas_upshifts" /id="D562" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="4.4421" /MaxDrop="2.9095" /score="14.183693" /energy="-15.3" /TU="U831,U832" /idTUdmin="U831" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" S_feature 1031787..1031897 /Source="Nicolas_S_feature" /locus_tag="new_1107562_1107672" /HighExp="Etha, dia15, LoTm, Salt, H2O2, LBGexp, Diami, Paraq, dia5, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S364" promotor_-35 1031875..1031882 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1031898..1031917 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1031899 /Source="Nicolas_upshifts" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1031958..1032929 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16672620, 20147287; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III) siderophore-binding lipoprotein" /protein_id="NP_388914.2" /db_xref="EnsemblGenomes-Gn:BSU10330" /db_xref="EnsemblGenomes-Tr:CAB12873" /db_xref="GOA:C0SP94" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG13061" /db_xref="UniProtKB/Swiss-Prot:C0SP94" /translation="MKKTLIILTVLLLSVLTAACSSSSGNQNSKEHKVAVTHDLGKTN VPEHPKRVVVLELGFIDTLLDLGITPVGVADDNKAKQLINKDVLKKIDGYTSVGTRSQ PSMEKIASLKPDLIIADTTRHKKVYDQLKKIAPTIALNNLNADYQDTIDASLTIAKAV GKEKEMEKKLTAHEEKLSETKQKISANSQSVLLIGNTNDTIMARDENFFTSRLLTQVG YRYAISTSGNSDSSNGGDSVNMKMTLEQLLKTDPDVIILMTGKTDDLDADGKRPIEKN VLWKKLKAVKNGHVYHVDRAVWSLRRSVDGANAILDELQKEMPAAKK*" /label="yhfQ CDS" gene 1031958..1032929 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /label="yhfQ gene" downshifts 1032908 /Source="Nicolas_upshifts" /id="D563" /incds=0 /nref=172 /ntot=251 /MaxReadThrough="2.22013" /MaxDrop="5.6726" /score="27.9181244" /energy="-10.9" /TU="NA" /idTUdmin="U833" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1032961..1033542) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10869096, 11827481, 12870714, 17693564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869096, 11827481, 12870714, 17693564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase; putative (phosphoglycerate) mutase" /protein_id="NP_388915.1" /db_xref="EnsemblGenomes-Gn:BSU10340" /db_xref="EnsemblGenomes-Tr:CAB12874" /db_xref="GOA:O07617" /db_xref="InterPro:IPR001345" /db_xref="InterPro:IPR013078" /db_xref="InterPro:IPR029033" /db_xref="SubtiList:BG13062" /db_xref="UniProtKB/Swiss-Prot:O07617" /translation="MTAVCLVRHGETDWNLQQKCQGKTDIPLNATGERQARETGEYVK DFSWDIIVTSPLKRAKRTAEIINEYLHLPIVEMDDFKERDYGDAEGMPLEERTKRYPD NIYPNMETLEELTDRLMGGLAKVNQAYPNKKVLIVAHGAAIHALLTEISGGDPELQST RLVNACLSNIEFAEEKWRIKDYNINSHLSGFIK*" /label="phoE CDS" gene complement(1032961..1033542) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /label="phoE gene" downshifts complement(1032984) /Source="Nicolas_upshifts" /id="D564" /incds=0 /nref=218 /ntot=256 /MaxReadThrough="1.23197" /MaxDrop="6.359" /score="28.9228703" /energy="-10.9" /TU="NA" /idTUdmin="U834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1033566..1033585) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1033578) /Source="Nicolas_upshifts" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1033601..1033604) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1033613..1034707) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /EC_number="2.3.1.9" /experiment="publication(s) with functional evidences, PMID:12368242, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acetyltransferase" /protein_id="NP_388916.1" /db_xref="EnsemblGenomes-Gn:BSU10350" /db_xref="EnsemblGenomes-Tr:CAB12875" /db_xref="GOA:O07618" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG13063" /db_xref="UniProtKB/Swiss-Prot:O07618" /translation="MNAVIVDAKRTIFGNQNGLLKPFLPEDLAAPIIRCLSRKLEDQV DEVILGNATGRGGNLARLSALQAGLPLSVPGMTIDRQCGSGLEAVRYACSLIQAGAGT MYIAGGSESSSQSPFSERARFSPDAIGDPDMGIAAEYTAARYSISRSMQDEYALLSHQ RSRNAHDEGFYREEVVALGELETDEAFLKTRPIEAIIPRAKPVFDTSSGTVTAANSSG IADGAAALLVMEEEKAAALGLKPVLRFIGSAVSGIHPNFPPAAPVVAIRQLLHTHDVT PDDIDLFEINEAFAVKICVCSQELGIPFSKINVRGGALALGHPYGASGAALVTRLFYE AKRRPDCQYAVAAIGSGGGIGLALLFEVLA*" /label="yhfS CDS" gene complement(1033613..1034707) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /label="yhfS gene" CDS complement(1034704..1036143) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12368242, 28032445, 28414710; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative long-chain fatty-acid-CoA ligase (proofreading for biotin synthesis)" /protein_id="NP_388917.1" /db_xref="EnsemblGenomes-Gn:BSU10360" /db_xref="EnsemblGenomes-Tr:CAB12876" /db_xref="GOA:O07619" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13064" /db_xref="UniProtKB/Swiss-Prot:O07619" /translation="MTITHTYSSTAETSPGRVAIQTESEQITYHDWDRLVSQTANWLR SQPSMPNRVAILLPNSLAFLQLFAGAAAAGCTAIPIDTRWSPAECKERLSISNADLVV TLAFFKNKLTDSQTPVVLLDNCMADISEAAADPLPTIDPEHPFYMGFTSGSTGKPKAF TRSHRSWMESFTCTETDFSISSDDKVLIPGALMSSHFLYGAVSTLFLGGTVCLLKKFS PAKAKEWLCRESISVLYTVPTMTDALARIEGFPDSPVKIISSGADWPAESKKKLAAAW PHLKLYDFYGTSELSFVTFSSPEDSKRKPHSAGRPFHNVRIEIRNAGGERCQPGEIGK IFVKSPMRFSGYVNGSTPDEWMTVDDMGYVDEEGFLYISGRENGMIVYGGLNIFPEEI ERVLLACPEVESAAVVGIPDEYWGEIAVAVILGNANARTLKAWCKQKLASYKIPKKWV FADSLPETSSGKIARSRVKKWLEESVQYK*" /label="yhfT CDS" gene complement(1034704..1036143) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /label="yhfT gene" CDS complement(1036150..1036710) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12368242, 15849754, 16850406, 18931129, 23709504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="biotin transporter" /protein_id="NP_388918.1" /db_xref="EnsemblGenomes-Gn:BSU10370" /db_xref="EnsemblGenomes-Tr:CAB12877" /db_xref="GOA:O07620" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13065" /db_xref="UniProtKB/Swiss-Prot:O07620" /translation="MLKLIDMMHIAIFTALMAVLGFMPPLFLSFTPVPITLQTLGVML AGSILRPKSAFLSQLVFLLLVAFGAPLLPGGRGGFGVFFGPSAGFLIAYPLASWLISL AANRLRKVTVLRLFFTHIVFGIIFIYLLGIPVQAFIMHIDLSQAAFMSLAYVPGDLIK AAVSAFLAIKITQALSLSDTMFTKGG*" /label="bioY CDS" gene complement(1036150..1036710) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /label="bioY gene" misc_feature complement(1036160..1036179) /Source="Nicolas_upshift_promotors" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1036174) /Source="Nicolas_upshifts" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1036735..1036754) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1036749) /Source="Nicolas_upshifts" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1036769..1036776) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1036845..1038143) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="heme-based dioxygen sensor" /protein_id="NP_388919.1" /db_xref="EnsemblGenomes-Gn:BSU10380" /db_xref="EnsemblGenomes-Tr:CAB12878" /db_xref="GOA:O07621" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR009050" /db_xref="PDB:1OR4" /db_xref="PDB:1OR6" /db_xref="SubtiList:BG13066" /db_xref="UniProtKB/Swiss-Prot:O07621" /translation="MLFKKDRKQETAYFSDSNGQQKNRIQLTNKHADVKKQLKMVRLG DAELYVLEQLQPLIQENIVNIVDAFYKNLDHESSLMDIINDHSSVDRLKQTLKRHIQE MFAGVIDDEFIEKRNRIASIHLRIGLLPKWYMGAFQELLLSMIDIYEASITNQQELLK AIKATTKILNLEQQLVLEAFQSEYNQTRDEQEEKKNLLHQKIQETSGSIANLFSETSR SVQELVDKSEGISQASKAGTVTSSTVEEKSIGGKKELEVQQKQMNKIDTSLVQIEKEM VKLDEIAQQIEKIFGIVTGIAEQTNLLSLNASIESARAGEHGKGFAVVANEVRKLSED TKKTVSTVSELVNNTNTQINIVSKHIKDVNELVSESKEKMTQINRLFDEIVHSMKISK EQSGKIDVDLQAFLGGLQEVSRAVSHVAASVDSLVILTEE*" /label="hemAT CDS" gene complement(1036845..1038143) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /label="hemAT gene" downshifts complement(1036856) /Source="Nicolas_upshifts" /id="D565" /incds=0 /nref=209 /ntot=243 /MaxReadThrough="2.70691" /MaxDrop="6.97357" /score="5.86442746" /energy="-6.9" /TU="NA" /idTUdmin="U837" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1038197..1038215) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1038200) /Source="Nicolas_upshifts" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1038229..1038235) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1038282..1039811) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with Rieske [2Fe-2S] center" /protein_id="NP_388920.1" /db_xref="EnsemblGenomes-Gn:BSU10390" /db_xref="EnsemblGenomes-Tr:CAB12879" /db_xref="GOA:O07622" /db_xref="InterPro:IPR005805" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG13067" /db_xref="UniProtKB/Swiss-Prot:O07622" /translation="MANQHFAKEAPETYWKTSTDLPSFPALQEDTECDVTIIGGGITG ITTAYELTKRGFRVVLIEANQVLNGTTAHTTAKVTAQHDMIYDEFIRHFGLNHARLYY EANQNAIDYIKGIVDEHQIDCEWIEQDAYLYTANENAVQKIHTEHEAYTKLGIERDLI KDLPIPLGSKLALVMKNQAQFHPLQYLKALLEQIVQKGGRIYEETVALDIKKGERPEV VTKSRHAIKSRFIICCSHFPFYDGGGLYAARMYSDRSYVLAIKPKIEYPEGMYLSIDQ PSVALRYTVVNGEKLILFSGVSHKTGQGKAMSTHYETLRQLAESTIGIESIPYYWSTQ DLVTIDKIPFIGPMSENEDNILVATGFKKWGMTSSAVAATLLSDLVEKKENPYESIFT PSRFHLNPGLQKVISYNADVAKHLIKGKLEKPDVQFEDISPGEGKAVTINGRRAGAFR DETGCLHLVDTTCTHLGCEVEWNDSEHTWDCPCHGSRFKPSGEVVEGPAIKPLKQIDL D*" /label="yhfW CDS" gene complement(1038282..1039811) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /label="yhfW gene" promotor_-10 complement(1039838..1039856) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1039848) /Source="Nicolas_upshifts" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1039867..1039872 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1039871..1039876) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1039884 /Source="Nicolas_upshifts" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1039888..1039906 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1039923..1040780 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18643936, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388921.1" /db_xref="EnsemblGenomes-Gn:BSU10400" /db_xref="EnsemblGenomes-Tr:CAB12880" /db_xref="GOA:P40397" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11058" /db_xref="UniProtKB/Swiss-Prot:P40397" /translation="MANQKKKTLPPQHQNQQPGFEYLMDPRPVFDKPKKAKKLEGKTA IITGGDSGIGRAVSVLFAKEGANVVIVYLNEHQDAEETKQYVEKEGVKCLLIAGDVGD EAFCNDVVGQASQVFPSIDILVNNAAEQHVQPSIEKITSHQLIRTFQTNIFSMFYLTK AVLPHLKKGSSIINTASITAYKGNKTLIDYSATKGAIVTFTRSLSQSLVQQGIRVNAV APGPIWTPLIPASFAAKDVEVFGSDVPMERPGQPVEVAPSYLYLASDDSTYVTGQTIH VNGGTIVNG*" /label="yhxC CDS" gene 1039923..1040780 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /label="yhxC gene" downshifts 1040762 /Source="Nicolas_upshifts" /id="D566" /incds=0 /nref=10 /ntot=36 /MaxReadThrough="2.65833" /MaxDrop="4.80135" /score="-8.69335909" /energy="-4.5" /TU="NA" /idTUdmin="U839" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1040808..1041041) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388922.1" /db_xref="EnsemblGenomes-Gn:BSU10410" /db_xref="EnsemblGenomes-Tr:CAB12881" /db_xref="InterPro:IPR014957" /db_xref="SubtiList:BG13087" /db_xref="UniProtKB/Swiss-Prot:O31594" /translation="MKEKKSYTELMKSRNTQKTKEFDVTMTDIYIQMVLDESLYNRRL AMLTDQINKALDEKDKDAFLTLSKEYAALKQSE*" /label="yhzC CDS" gene complement(1040808..1041041) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /label="yhzC gene" downshifts complement(1040841) /Source="Nicolas_upshifts" /id="D567" /incds=0 /nref=191 /ntot=247 /MaxReadThrough="3.34616" /MaxDrop="7.00218" /score="21.4902337" /energy="-12.3" /TU="U841" /idTUdmin="U844" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1041058..1041077) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1041061..1041062 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1041061 /Source="Nicolas_upshifts" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1041065..1041080 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1041080) /Source="Nicolas_upshifts" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1041082..1041937) /Source="Nicolas_S_feature" /locus_tag="new_1116857_1117712_c" /HighExp="Salt, Etha, C30, Heat, S8, LPhT, Gly, C90, S7, UNK1" /AntisenseName="comK" /AntisenseCor="-5.68778941053006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S365" promotor_-35 complement(1041092..1041099) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1041264..1041271 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-35" promotor_-10 1041283..1041302 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-10" upshifts 1041289 /Source="Nicolas_upshifts" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="upshifts" CDS 1041334..1041912 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence transcription factor (CTF)" /protein_id="NP_388923.1" /db_xref="EnsemblGenomes-Gn:BSU10420" /db_xref="EnsemblGenomes-Tr:CAB12882" /db_xref="GOA:P40396" /db_xref="InterPro:IPR010461" /db_xref="SubtiList:BG11059" /db_xref="UniProtKB/Swiss-Prot:P40396" /translation="MSQKTDAPLESYEVNGATIAVLPEEIDGKICSKIIEKDCVFYVN MKPLQIVDRSCRFFGSSYAGRKAGTYEVTKISHKPPIMVDPSNQIFLFPTLSSTRPQC GWISHVHVKEFKATEFDDTEVTFSNGKTMELPISYNSFENQVYRTAWLRTKFQDRIDH RVPKRQEFMLYPKEERTKMIYDFILRELGERY*" /label="comK CDS" gene 1041334..1041912 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /label="comK gene" S_feature 1041913..1042058 /Source="Nicolas_S_feature" /locus_tag="new_1117688_1117833" /HighExp="GM 150, C30, T-4.40H, T-3.40H, GM 120, M9-tran, T-2.40H, C90, G/S, T-1.10H" /AntisenseName="yhxD" /AntisenseCor="-0.229484184862048" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S366" CDS complement(1041959..1042858) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388924.1" /db_xref="EnsemblGenomes-Gn:BSU10430" /db_xref="EnsemblGenomes-Tr:CAB12883" /db_xref="GOA:P40398" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11060" /db_xref="UniProtKB/Swiss-Prot:P40398" /translation="MSDSNLTNPIKAFFHDEFPEQYQEPPGLQKNMKPVPDCGEKSYK GSGKLTGRKALVTGGDSGIGRAAAIAYAREGADVAINYLPEEQPDAEEVKELIEAEGR KAVLIPGDLSDESFCQDLVKQSHHELGGLDVLALVAGKQQAVENIEDLPTEQIYKTFE VNVFSLYWVVKAALPYLPEGASIITTTSVEGYNPSPMLLDYAATKNAIIGFTVGLGKQ LASKGIRVNSVAPGPIWTPLQISGGQPTENIPKFGQGTPPAPLNRAGQPVELADVYVF LASENSSYVTSQVYGITGGIPTA*" /label="yhxD CDS" gene complement(1041959..1042858) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /label="yhxD gene" downshifts complement(1041982) /Source="Nicolas_upshifts" /id="D568" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="4.95535" /MaxDrop="4.1467" /score="-2.68458203" /energy="-14.6" /TU="U844" /idTUdmin="U844" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1042045..1042048 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1042060 /Source="Nicolas_upshifts" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1042066..1042070 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1042104 /Source="Nicolas_upshifts" /id="D569" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="5.45904" /MaxDrop="5.6543" /score="-8.69335909" /energy="-4.5" /TU="U842" /idTUdmin="U843" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1042149..1043015 /Source="Nicolas_S_feature" /locus_tag="new_1117924_1118790" /HighExp="GM 150, C30, T-4.40H, C90, T-3.40H, T-2.40H, G/S, T-5.40H, M9-tran, nit" /AntisenseName="yhxD" /AntisenseCor="-0.32746434250834699" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S367" promotor_-10 complement(1042885..1042903) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1042902) /Source="Nicolas_upshifts" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1042918..1042924) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1042992..1042999 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1043014..1043033 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1043017 /Source="Nicolas_upshifts" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1043075..1043344 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388925.1" /db_xref="EnsemblGenomes-Gn:BSU10440" /db_xref="EnsemblGenomes-Tr:CAB12884" /db_xref="InterPro:IPR008613" /db_xref="SubtiList:BG13068" /db_xref="UniProtKB/Swiss-Prot:O07555" /translation="MKKAAAVLLSLGLVFGFSYGAGHVAEAKTKVKVYKNCKELNKVY KGGVARTSKVKNKGGKTKYKPYVSKALYDANKNKDRDKDLIACER*" /label="yhjA CDS" gene 1043075..1043344 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /label="yhjA gene" downshifts 1043336 /Source="Nicolas_upshifts" /id="D570" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.67325" /MaxDrop="7.59695" /score="27.4895724" /energy="-11.2" /TU="NA" /idTUdmin="U845" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1043384) /Source="Nicolas_upshifts" /id="D571" /incds=0 /nref=11 /ntot=113 /MaxReadThrough="2.40747" /MaxDrop="4.60953" /score="20.2036192" /energy="-11.2" /TU="NA" /idTUdmin="U846" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1043387..1044856) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite cotransporter" /protein_id="NP_388926.1" /db_xref="EnsemblGenomes-Gn:BSU10450" /db_xref="EnsemblGenomes-Tr:CAB12885" /db_xref="GOA:O07556" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13069" /db_xref="UniProtKB/Swiss-Prot:O07556" /translation="MNAALIIIFGVLLLSIFLGIRAQKGKDMNLEQWTVGGRGFGTVF VFLLMAGEIYTTFTFLGGSGWAYGKGGPAFYIIAYGCLAYILSYWLLPAVWTYAKQHK LMSQSDFFTKKYNSPLLGILVSLVGIAALIPYLVLQLKGLGLIVSETSYGKITPTAAI WIGAVSITVYVMVSGIHGSAWISVVKDIMILVVVLFLGVYLPIHYYGGFQDMFQQIET AKPGFLTLPESGQSVAWFSSTVLLTALGFYMWPHTFSASYSAENPKVFRKNAIIMPLY QLVLLFVLFVGFAAILQVPDLNGADGDLSLLRLSLQAFDPWFVGIIGAAGLLTALVPG SMILMSASTLFAKNVYKVIAPRTTEQQVSALAKFLVPVIALISVYFTFKGGNTIVTLL LMGYSLVTQLFPALLFSLLKHNMVTKQGAFAGIIAGVGAVTYITMTETTIGTLFPALP QAAKDLNVGIVALLLNITVMMAVSLMTRKAKSAAADQAA*" /label="yhjB CDS" gene complement(1043387..1044856) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /label="yhjB gene" CDS complement(1044853..1045053) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388927.1" /db_xref="EnsemblGenomes-Gn:BSU10460" /db_xref="EnsemblGenomes-Tr:CAB12886" /db_xref="GOA:O07557" /db_xref="InterPro:IPR021741" /db_xref="SubtiList:BG13070" /db_xref="UniProtKB/Swiss-Prot:O07557" /translation="MKLIHVLAALPFIGILLGIPFANKVTPYVFGMPFILAYIVMWAL LTSALMAIVYVLDKENKKEEAE*" /label="yhjC CDS" gene complement(1044853..1045053) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /label="yhjC gene" S_feature complement(1045054..1045172) /Source="Nicolas_S_feature" /locus_tag="new_1120829_1120947_c" /HighExp="S1, Etha, HiOs, MG 120, LoTm, T-5.40H, S2, GM-0.1, GM-0.2, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S368" promotor_-10 complement(1045155..1045174) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1045172) /Source="Nicolas_upshifts" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1045187..1045194) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1045260) /Source="Nicolas_upshifts" /id="D572" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.99656" /MaxDrop="2.67326" /score="20.2036192" /energy="-11.2" /TU="U848" /idTUdmin="U848" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(1045261..1045623) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388928.1" /db_xref="EnsemblGenomes-Gn:BSU10470" /db_xref="EnsemblGenomes-Tr:CAB12887" /db_xref="GOA:O07558" /db_xref="SubtiList:BG13071" /db_xref="UniProtKB/Swiss-Prot:O07558" /translation="MPNLQEEIYDLIERALFLPMAITIFNRDLAGIEESTLKLKHPYK QLISESLKIAQKDLMEVRKELRKRKIAIRETERDEAFTLYTFVIDGYEENHRYFNPRI REQVSELLTYYLFAPDRL*" /label="yhjD CDS" gene complement(1045261..1045623) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /label="yhjD gene" promotor_-35 1045461..1045466 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1045482..1045500 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1045483 /Source="Nicolas_upshifts" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1045492..1045731 /Source="Nicolas_S_feature" /locus_tag="new_1121267_1121506" /HighExp="S6, S4, S8, S5, LoTm, B36, S3, S7, BT, B60" /AntisenseName="yhjD" /AntisenseCor="0.24202608585419999" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S369" promotor_-10 complement(1045653..1045672) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1045671) /Source="Nicolas_upshifts" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1045687..1045694) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1045713..1045720 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1045733 /Source="Nicolas_upshifts" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1045734..1045753 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1045775..1046398 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388929.1" /db_xref="EnsemblGenomes-Gn:BSU10480" /db_xref="EnsemblGenomes-Tr:CAB12888" /db_xref="GOA:O07559" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13072" /db_xref="UniProtKB/Swiss-Prot:O07559" /translation="MLEHFLSYLTQEHLTELFQSYRAFGPLIAVLLPLIEAFLPFLPL IVFVVANTNSFGLWEGFILSWAGSTAGSILVFLIVRQYGQRKLLGFIRSHPSVRKLML WVERHGFGPMFLLLCFPFTPSAAVNVVAGLSRIGTRPFILAAASGKLVMIFMISFIGY DLHALITQPIRTVIAVLVITVLWYVGKKVERYLHVRASQREHDGGRQ*" /label="yhjE CDS" gene 1045775..1046398 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /label="yhjE gene" CDS 1046400..1046906 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /EC_number="3.4.21.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9325333, 9694797, 11309398, 12897006, 14568161, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 9694797, 11309398, 12897006, 14568161, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388930.1" /db_xref="EnsemblGenomes-Gn:BSU10490" /db_xref="EnsemblGenomes-Tr:CAB12889" /db_xref="GOA:O07560" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG12674" /db_xref="UniProtKB/Swiss-Prot:O07560" /translation="MKKRFWFLAGVVSVVLAIQVKNAVFIDYKVEGVSMNPTFQEGNE LLVNKFSHRFKTIHRFDIVLFKGPDHKVLIKRVIGLPGETIKYKDDQLYVNGKQVAEP FLKHLKSVSAGSHVTGDFSLKDVTGTSKVPKGKYFVVGDNRIYSFDSRHFGPIREKNI VGVISDAE*" /label="sipV CDS" gene 1046400..1046906 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /label="sipV gene" downshifts 1046899 /Source="Nicolas_upshifts" /id="D573" /incds=0 /nref=131 /ntot=250 /MaxReadThrough="0.63331" /MaxDrop="4.58282" /score="-7.37718733" /energy="-7.1" /TU="NA" /idTUdmin="U847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1046957..1046964 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1046978..1046997 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1046987..1047086 /Source="Nicolas_S_feature" /locus_tag="new_1122762_1122861" /HighExp="LBGstat, LBGexp, Lbtran, C90, dia0, Lbexp, HPh, dia5, aero, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S370" upshifts 1046987 /Source="Nicolas_upshifts" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="upshifts" CDS 1047087..1048586 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7678243, 15121720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic compound monooxygenase/hydroxylase" /protein_id="NP_388931.1" /db_xref="EnsemblGenomes-Gn:BSU10500" /db_xref="EnsemblGenomes-Tr:CAB12890" /db_xref="GOA:O07561" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13073" /db_xref="UniProtKB/Swiss-Prot:O07561" /translation="MMMKYEAVIIGGGPVGFMLASELAIAGVGTCVIERLEKPVPHSK ALTLHPRTLELLEMRGILERFVSKGSKIPTGHFSMLDTRLDFSGLDTSCPYTLLLPQS KTEKLLEDHARSLGTEVFRGAEALAVTQNGEAVQTIFKDRDGSVRTITSKFAVGADGA GSTVRKQAKIEFPGTDSTVTAALGDVVLLSPPPSGVLSLCTKEGGVMIVPLSPDRYRV VVISPYRTQTPKDVPVTEEELKADLLRICGTDFGLTDPSWMSRFGNAARQAKRYRDGR IFLAGDAAHIHFPAGGQGLNVGLQDAMNLGWKLAAAIKGSAPSWLLDSYHDERHPAAE GLLRNTEAQTKLIDFTQAGLHLRSMMSELLAFPDVNRYVAGQISALDVRYEADRTMPP NRLNGARLPDMKLILSDGNSERLYSFLQNGTFVLLSLRQEADDHIEVKGLRTVTASLA EPNEKLRNVHTILIRPDGHVAWAVDASAPDCSEVIQKGISRWFSVTSRV*" /label="yhjG CDS" gene 1047087..1048586 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /label="yhjG gene" promotor_-35 1048594..1048601 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1048613 /Source="Nicolas_upshifts" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1048615..1048634 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1048663..1049190 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388932.1" /db_xref="EnsemblGenomes-Gn:BSU10510" /db_xref="EnsemblGenomes-Tr:CAB12891" /db_xref="GOA:Q796S4" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13074" /db_xref="UniProtKB/Swiss-Prot:Q796S4" /translation="MNTDHTKRNLFELYAELIHQQEKWEGLIKAFLSDELRKLDVEHG SKSQLTMTEIHVLSCVGDNEPINVTSIAEKMNTTKATVSRISTKLLGAGFLHRTQLSD NKKEVYFRLTPAGKKLHSLHKYYHQKAEQRFLSFFDRYTEEEILFAERLFRDLVTKWY PSSEEIEGGLPSIFK*" /label="yhjH CDS" gene 1048663..1049190 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /label="yhjH gene" downshifts 1049152 /Source="Nicolas_upshifts" /id="D574" /incds=0 /nref=8 /ntot=128 /MaxReadThrough="1.1509" /MaxDrop="3.41655" /score="11.3050978" /energy="-9.9" /TU="NA" /idTUdmin="U851" /TUdmin=8 /isTUend="TRUE" /label="downshifts" S_feature complement(1049204..>1049224) /Source="Nicolas_S_feature" /locus_tag="new_1124979_1125122_c" /HighExp="B36, B60, T0.30H, LBGstat, T1.30H, T1.0H, LPhT, LBGtran, Diami, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S371" SCAR join(1049224,1049240) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_001" N_region 1049225..1049239 /note="inserted sequence possibly derived from two restrictions with NotI and SacI" /created_by="User" /modified_by="User" /label="IIG_Bs27_001" S_feature <1049240..1049526 /Source="Nicolas_S_feature" /locus_tag="new_1130705_1131082" /HighExp="T4.0H, T5.0H, T3.30H, T2.0H, HiOs, T2.30H, T3.0H, LoTm, T1.30H, Pyr" /AntisenseName="yhjN" /AntisenseCor="-5.0383887616073E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig="0.997" /label="S375" S_feature complement(<1049240..1049361) /Source="Nicolas_S_feature" /locus_tag="new_1130759_1130917_c" /HighExp="B60, Sw, Cold, B36, BI, GM 15, GM 10, C30, GM 25, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S376" downshifts complement(1049246) /Source="Nicolas_upshifts" /id="D577" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="3.07371" /MaxDrop="4.24831" /score="-1.9470655" /energy="-7.1" /TU="U856" /idTUdmin="U856" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(1049362..1050516) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (recentHGT island)" /protein_id="NP_388938.1" /db_xref="EnsemblGenomes-Gn:BSU10570" /db_xref="EnsemblGenomes-Tr:CAB12897" /db_xref="GOA:O07568" /db_xref="InterPro:IPR007820" /db_xref="InterPro:IPR017516" /db_xref="SubtiList:BG13080" /db_xref="UniProtKB/Swiss-Prot:O07568" /translation="MKKDENLLKDLWFIAISAAGGFILSLTGISIGWMIGTLIVACCL AMIRPAWLMMAPDQKGINRRWLALGQMILGIELGQKLNLSVLSVLKDHWFSVGVMLIL SILLAMLSGYVLWRFSKTDMMTSFVGTAPGGLSAMPSIAQEVGANTAIVSLVQMMRVL LVVLSIPFLVILIYTKQDRTASAAAETISSATTDFRLAPVLWTVILILAAWGACKAAK FLKFPAPWLLGSMLGVAIVHVGGAAVTGHDMTAWWLSQANHVSQVFLGATIGSKMYKS MFAGVTRIIIVGFVSSVGLIAAMFLSAVIVSELTGISLITSVLAFAPGGIAEMATTSV TLHADSTFVVAVQVIRVILVIALLPPFYRLLHHLHGEKKDKKSSISGSSA*" /label="yhjN CDS" gene complement(1049362..1050516) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /label="yhjN gene" S_feature complement(1050517..1050588) /Source="Nicolas_S_feature" /locus_tag="new_1132073_1132144_c" /HighExp="Cold, GM 15, GM 10, dia15, BC, BI, Salt, B60, Sw, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S377" promotor_-10 complement(1050571..1050590) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1050587) /Source="Nicolas_upshifts" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1050604..1050609) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1050623..1051828) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease (recent HGT island)" /protein_id="NP_388939.1" /db_xref="EnsemblGenomes-Gn:BSU10580" /db_xref="EnsemblGenomes-Tr:CAB12898" /db_xref="GOA:O07569" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13081" /db_xref="UniProtKB/Swiss-Prot:O07569" /translation="MLTSFHSIKSRYTAPVRLRFFGELLTSLTGAMMGPFMVLYLHEQ LNGSIMMPMLIISLQPFADIFLTLAAGRVTDRLGRRTAILTALLLQSAAMTGFVFAEH AYVFAILYVMNGIGRSLYIPASRAQIAESTPESRRSEVFAVINAIYSTGLTAGPLVGM LLYNHNPVWIFALDAAALFIYFLIAALKLPETKPLHPAVTPKMSASFTIYRPVLLLLL LSLPISMLYAQTETTYRLFSKNMFSDYLSMLTIYSAAKALFSCVLQVPLVKGTEKLSM KTILFITYICYSLAAAGFACSTSLTMLLVTAAVMTVGESIGLTHIQTFISKLAPPHLL GRFYAVYGLHWDISRSIGPLAGGLILTSFGGEVIFYALAVCLLTAGLSLTYTIEKLEH KVIRKVNRL*" /label="yhjO CDS" gene complement(1050623..1051828) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /label="yhjO gene" misc_feature 1051849..1051868 /Source="Nicolas_upshift_promotors" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1051854 /Source="Nicolas_upshifts" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1051942..1053669 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcription factor" /protein_id="NP_388940.1" /db_xref="EnsemblGenomes-Gn:BSU10590" /db_xref="EnsemblGenomes-Tr:CAB12899" /db_xref="GOA:O07570" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR025370" /db_xref="InterPro:IPR030678" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13082" /db_xref="UniProtKB/Swiss-Prot:O07570" /translation="MKLIEHYVALVKTGCAEYGQMNEMTLTEIADCLFCTERNAKLIL HKLENSNWIIRESGAGRGRKSKIAFLRRPEELLLQTAKEYTMSGKLKKAKELLQQYQS AFPGLQNEYNMWLSEVFGFVTETGENGAKDVLRLFITPESVSSLDPCQIFLRSEGHFV KQIFDTLFTFDSDMQEPKPHLVHGWEEVGKKQWRFFLRKGVLFHNGQPLTSRDVAFTF QRFLELADNPYKWLLHGVKQVLEKGPYCVELILDKPNALLPYALCDERLSILPAEQGG GKNGTGPFQMNQQHSGMLVLEANERYFKGRPYLDRVEFVFSEQAGEMNGFTIQEKQTC PEQQTVFDERHVQYLSLNLKKKGPLQHRSFRKALRLLISSERLVREAGGHRRIPVTSF LHPSPFEWEGVSPSELLKKSGYEGETIVLYTFSETDHREDAEWIQNICAQHGIRLTLQ FCDAADLRRPEIVQMADIIHDSATFYQDSEFGFLHLLLSENSFLYQHLSEKLTQICSG MTERMFSMPDRCSRINILRDIDRQMIQELNAIPLYQNVLQVTSSKNVKGLVLDEEGWI DLYSVWLSK*" /label="yhjP CDS" gene 1051942..1053669 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /label="yhjP gene" promotor_-35 1053255..1053262 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1053277..1053296 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1053284 /Source="Nicolas_upshifts" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1053699..1054025) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12625841; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative metal-chelating cysteine-rich protein of unknown function" /protein_id="NP_388941.1" /db_xref="EnsemblGenomes-Gn:BSU10600" /db_xref="EnsemblGenomes-Tr:CAB12900" /db_xref="InterPro:IPR005560" /db_xref="PDB:5FIG" /db_xref="SubtiList:BG13083" /db_xref="UniProtKB/Swiss-Prot:O07571" /translation="MEQYSEACIEACIDCMKACNHCFTKCLEESVQHHLSGCIRLDRE CADICALAVKAMQTDSPFMKEICALCADICEACGTECGKHDHDHCQACAKACFTCAEQ CRSMAA*" /label="yhjQ CDS" gene complement(1053699..1054025) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /label="yhjQ gene" CDS complement(1054143..1054580) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22078549, 22882546; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative electron carrier protein (putative sporulation gene)" /protein_id="NP_388942.1" /db_xref="EnsemblGenomes-Gn:BSU10610" /db_xref="EnsemblGenomes-Tr:CAB12901" /db_xref="GOA:O07572" /db_xref="InterPro:IPR003251" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13084" /db_xref="UniProtKB/Swiss-Prot:O07572" /translation="MHYSYYPYPVPYREDPVLIRNLQKAINGEFSAIQCYRKLAELAH SDEVRKQIEEIRRDEIRHLREFSTLYGSITGKHIMPKQTEECPDNFTRGLDAAFKDEQ ETVDFYLRAAEETSNLKAKGVFTRAARDEQNHAVWFLYYLMER*" /label="yhjR CDS" gene complement(1054143..1054580) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /label="yhjR gene" downshifts complement(1054152) /Source="Nicolas_upshifts" /id="D578" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.72767" /MaxDrop="3.86885" /score="16.2430017" /energy="-11.5" /TU="U859" /idTUdmin="U859" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1054611..1054630) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1054631) /Source="Nicolas_upshifts" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1054643..1054652) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1054700..1054707 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1054721..1054740 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1054733 /Source="Nicolas_upshifts" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="upshifts" CDS 1054764..1058264 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit B)" /protein_id="NP_388943.2" /db_xref="EnsemblGenomes-Gn:BSU10620" /db_xref="EnsemblGenomes-Tr:CAB12902" /db_xref="GOA:P23477" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014140" /db_xref="InterPro:IPR027417" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10465" /db_xref="UniProtKB/Swiss-Prot:P23477" /translation="MGAEFLVGRSGSGKTKLIINSIQDELRRAPFGKPIIFLVPDQMT FLMEYELAKTPDMGGMIRAQVFSFSRLAWRVLQHTGGMSRPFLTSTGVQMLLRKLIEE HKQEFKVYQKASDKSGFTAQVERMLTEFKRYCLEPEDIRRMAESGTASEYRGERVLSE KLHDLSILYQQMEKSLADQYLHSEDYLTLLAEHIPLAEDIKGAHIYVDGFYQFTPQEF RVLEQLMVHAEHITFSLTADKPSYEREPHELELFRMTGKTYYRLHQKAKELNLDITYK ELSGTERHTKTPELAHLEAQYEARPAIPYAEKQEALTVMQAANRRAELEGIAREIHAL VREKGYRYKDVAILARQPEDYKDMVKEVFADYEIPYFIDGKASMLNHPLIEFIRSSLD VLKGNWRYEAVFRCVKTELLFPLNEPKAKVREQVDQLENYCIAYGIKGDRWTKGDRFQ YRRFVSLDDDFAQTDQEIEMENMLNDTRDWIVPPLFQLQKRMKKAKTVQEKAEALYRY LEETDVPLKLDQERQRAEDDGRIIEAQQHQQAWDAVIQLLEEFVEMMGDDEISLDLFQ QMIEAGAESLTFSLIPPALDQVFVGNMDLSRMYGTSCTFVLGANDGVLPARPDENGVL SDDDREWLKTIGVELSSGGRERLLDEHFLIYMAFSSPSDRLYVSYPIADAEGKTLLPS MIVKRLEELFPHHKERLLTNEPEQVSDEEQLMYVVNKSVAQSFTASQLRLWTREYDIS DVWWSTYNVLMSEQDRLQSKKLFSSLFFRNEVKQLERSVSRQLYGERIQGSVSRMETF NACPFSHFASHGLHLKERQFFKLEAPDIGQLFHSSLKLISDRLREQKLDWRDLTKEQC ELFSYDAVERLAPKLQKEILLSSNRHYYVKEKLQKIVTRVSGILSEHAKASGFVPIGL ELGFGGKGPLPPLTFQLKNGCTMELVGRIDRVDKAESSKGLLLRIVDYKSSDKGLDLA EVYYGLALQMLTYLDLSITHSADWLGMRATPAGVLYFHIHDPMIQSNLPLGLDEIEQE IFKKFKMKGLLLGDQEVVRLMDTTLQEGRSNIINAGLKKDGSLRSDSAAVGEKEFDLL TKHVRRTFQEAGEQITDGRVSIEPYKMKNKTPCTYCAFKSVCQFDESLEENEYRPLKA EKDKTILEWIKKEADGNEHS*" /label="addB CDS" gene 1054764..1058264 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /label="addB gene" CDS 1058251..1061949 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit A)" /protein_id="NP_388944.2" /db_xref="EnsemblGenomes-Gn:BSU10630" /db_xref="EnsemblGenomes-Tr:CAB12903" /db_xref="GOA:P23478" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR011335" /db_xref="InterPro:IPR011604" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014152" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10466" /db_xref="UniProtKB/Swiss-Prot:P23478" /translation="MNIPKPADSTWTDDQWNAIVSTGQDILVAAAAGSGKTAVLVERM IRKITAEENPIDVDRLLVVTFTNASAAEMKHRIAEALEKELVQRPGSLHIRRQLSLLN RASISTLHSFCLQVLKKYYYLIDLDPGFRIADQTEGELIGDEVLDELFEDEYAKGEKA FFELVDRYTTDRHDLDLQFLVKQVYEYSRSHPNPEAWLESFVHLYDVSEKSAIEELPF YQYVKEDIAMVLNGAKEKLLRALELTKAPGGPAPRADNFLDDLAQIDELIQHQDDFSE LYKRVPAVSFKRAKAVKGDEFDPALLDEATDLRNGAKKLLEKLKTDYFTRSPEQHLKS LAEMKPVIETLVQLVISYGKRFEAAKQEKSIIDFSDLEHYCLAILTAENDKGEREPSE AARFYQEQFHEVLVDEYQDTNLVQESILQLVTSGPEETGNLFMVGDVKQSIYRFRLAE PLLFLSKYKRFTESGEGTGRKIDLNKNFRSRADILDSTNFLFKQLMGGKIGEVDYDEQ AELKLGAAYPDNDETETELLLIDNAEDTDASEEAEELETVQFEAKAIAKEIRKLISSP FKVYDGKKKTHRNIQYRDIVILLRSMPWAPQIMEELRAQGIPVYANLTSGYFEAVEVA VALSVLKVIDNPYQDIPLASVLRSPIVGADENELSLIRLENKKAPYYEAMKDYLAAGD RSDELYQKLNTFYGHLQKWRAFSKNHSVSELIWEVYRDTKYMDYVGGMPGGKQRQANL RVLYDRARQYESTAFRGLFRFLRFIERMQERGDDLGTARALSEQEDVVRLMTIHSSKG LEFPVVFVAGLGRNFNMMDLNKSYLLDKELGFGTKYIHPQLRISYPTLPLIAMKKKMR RELLSEELRVLYVALTRAKEKLFLIGSCKDHQKQLAKWQASASQTDWLLPEFDRYQAR TYLDFIGPALARHRDLGDLAGVPAHADISGHPARFAVQMIHSYDLLDDDLEERMEEKS ERLEAIRRGEPVPGSFAFDEKAREQLSWTYPHQEVTQIRTKQSVSEIKRKREYEDEYS GRAPVKPADGSILYRRPAFMMKKGLTAAEKGTAMHTVMQHIPLSHVPSIEEAEQTVHR LYEKELLTEEQKDAIDIEEIVQFFHTEIGGQLIGAKWKDREIPFSLALPAKEIYPDAH EADEPLLVQGIIDCLYETEDGLYLLDYKSDRIEGKFQHGFEGAAPILKKRYETQIQLY TKAVEQIAKTKVKGCALYFFDGGHILTL*" /label="addA CDS" gene 1058251..1061949 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /label="addA gene" S_feature 1061950..1062020 /Source="Nicolas_S_feature" /locus_tag="new_1143506_1143576" /HighExp="H2O2, C90, Heat, LBGtran, dia15, HiTm, Diami, C30, Lbtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S378" CDS 1062021..1063196 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7968921, 8493111, 16780573" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7968921, 8493111, 16780573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair exonuclease" /protein_id="NP_388945.3" /db_xref="EnsemblGenomes-Gn:BSU10640" /db_xref="EnsemblGenomes-Tr:CAB12904" /db_xref="GOA:P23479" /db_xref="InterPro:IPR004593" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR026843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG10467" /db_xref="UniProtKB/Swiss-Prot:P23479" /translation="MRILHTADWHLGKTLEGRSRLSEQADVLDELNTIVKDEQIDAIV MAGDAFDTVNPPALAEQLFYESLSALSDRGKRPIVVIAGNHDNPDRLSAASPLTHENG IHLIGYPTTEPIHIEVPSAGELLAVGALAYPSEARLNEVLSDTFDEKLLRDHYDVKIR QAFEHMTSRFRTDAVKIAASHIYVAGGNQTDSERPIEVGGAYTVAAESLPADAAYVAL GHLHRPQTIKRARTLARYSGSPLAYSFSEAGYAKSVTIVDAKPGEEATWQEVLLSSGK PLVKWKAANGLSEVYSWLDEGRDQNAWIDLEIRVADQLSLEEIHRLRKAHPGFIHIRP VFEEQNKDRERIEVKHVSIEDRFKKFYEKQTGGAVPDEEMVKLFLELASGVEEEDAK* " /label="sbcD CDS" gene 1062021..1063196 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /label="sbcD gene" CDS 1063193..1066585 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 19906728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 19906728; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ATP-dependent repair enzyme" /protein_id="NP_388946.2" /db_xref="EnsemblGenomes-Gn:BSU10650" /db_xref="EnsemblGenomes-Tr:CAB12905" /db_xref="GOA:O06714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13088" /db_xref="UniProtKB/Swiss-Prot:O06714" /translation="MKPIALSIKGLHSFREEQTIDFEGLSGAGVFGIFGPTGSGKSSI LDAMTLALYGKVERAANNTHGILNHAEDTLSVSFTFALQTNHQISYKVERVFKRTDEM KVKTALCRFIEIKDEHTVLADKASEVNKRVEELLGLTIDDFTRAVVLPQGKFAEFLSL KGAERRHMLQRLFNLEQYGDRLVKKLRRQAQEANARKNEMLAEQSGLGEASSEAVEQA EKVLEQAEARLEAMRKNRDQAKERFTEHQEIWNVQKEKSTYEEEEKRLAEEQPHIDSM QKRLLEAETAAALKPYADRYAEAIQHEEQAEKEQTLAQKDLADRTAFFQQKHEEYEAW RQHKSEKEPELLAKQEQLSRLQEIEIKLSEAKQEEERKKADLRQKEEALQSVMNELET VTDRLTRGQNRQTELKQQLKSLQVTSDERKSCQQAAEMALRIRQTEEQIKKEKKRSEE LNLVLQKMNEEKNTLVQKTEAEENNIIQAYEAVQTVYHLVCETERSLTRMTEEARKSQ HTLHLQREKARVALLTKELAQKLTAGKPCPVCGSTDHDPSASVHETYEADSHLEEDIK RTDVLLTEAAALSQEILSAKIMLEEQSARFIEQCPFLQTIQAQNLEAAASFEHQPVYE AFETAKFEWKRIKQDILSVKTRMAQMIGAYQESLKKAEQLNEKIGFEKREADRIESII SELQSSMDSSLNMFKEAFQNQSVDEAEKWQQAIEEKDRAAEECEKRIEKSIAFLAEHE AQKEKLRESGHRLEREKLELHYAAERIKSVIADYEHELGDYAKGDSIQIKLRSVQQDL KLLKEKEQSLYEELQSAQMKLNQAKSRASASELTLQEAKGRLEKAKAAWLEHTKNTSI TRTEEVEQSLIPADELEKMKTGIDQFMDKLKQNAANLKRVAEILAGRALSESEWNETV AALQEAEDAFGAAIEEKGAAAKALAVIRDHHKRFNEIEAELKKWQMHIDRLDKLQAVF KGNTFVEFLAEEQLESVARDASARLSMLTRQRYAIEVDSEGGFVMRDDANGGVRRPVS SLSGGETFLTSLSLALALSAQIQLRGEYPLQFFFLDEGFGTLDQDLLDTVVTALEKLQ SDNLAVGVISHVQELRARLPKKLIVHPAEPSGRGTRVSLELM*" /label="sbcC CDS" gene 1063193..1066585 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /label="sbcC gene" promotor_-35 1065840..1065846 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1065861..1065872 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1065868 /Source="Nicolas_upshifts" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1065937..1066910) /Source="Nicolas_S_feature" /locus_tag="new_1147493_1148466_c" /HighExp="S6, S8, S7, BT, C30, B36, S5, C90, Pyr, B60" /AntisenseName="yisB" /AntisenseCor="0.19649597897587401" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S379" CDS 1066599..1066901 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 22984257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 22984257; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="HNH nuclease-like essential for DNA repair" /protein_id="NP_388947.1" /db_xref="EnsemblGenomes-Gn:BSU10660" /db_xref="EnsemblGenomes-Tr:CAB12906" /db_xref="SubtiList:BG13089" /db_xref="UniProtKB/Swiss-Prot:O06715" /translation="MAKQIAGICELCGRSDVQLTEHHLTPKEEGGTFLPTAMLCIPCH KQIHALYTNQELAVRLNGMAELRSDPELARFVKWIRKQPPEKLIKTKKSNERKKKK*" /label="hlpB CDS" gene 1066599..1066901 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /label="hlpB gene" downshifts 1066881 /Source="Nicolas_upshifts" /id="D579" /incds=0 /nref=230 /ntot=269 /MaxReadThrough="1.42126" /MaxDrop="6.71114" /score="0.317490594" /energy="-14.3" /TU="NA" /idTUdmin="U861" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1066938..1067156) /gene="gerPF" /locus_tag="BSU_10670" /old_locus_tag="BSU10670" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007, 20161744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007, 20161744; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388948.2" /db_xref="EnsemblGenomes-Gn:BSU10670" /db_xref="EnsemblGenomes-Tr:CAB12907" /db_xref="GOA:O06716" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13090" /db_xref="UniProtKB/Swiss-Prot:O06716" /translation="MPAIVGPIAINSISGGVVNFGDSFYLSPKSSSKSALGSGAGNTG DFLLLNNAVNATNYIDPDVNDQDMVGNG*" /label="gerPF CDS" gene complement(1066938..1067156) /gene="gerPF" /locus_tag="BSU_10670" /old_locus_tag="BSU10670" /label="gerPF gene" downshifts complement(1066955) /Source="Nicolas_upshifts" /id="D580" /incds=0 /nref=40 /ntot=66 /MaxReadThrough="3.93344" /MaxDrop="5.39228" /score="13.5435041" /energy="-15.3" /TU="U863" /idTUdmin="U863" /TUdmin="-989" /isTUend="FALSE" /label="downshifts" CDS complement(1067188..1067589) /gene="gerPE" /locus_tag="BSU_10680" /old_locus_tag="BSU10680" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388949.1" /db_xref="EnsemblGenomes-Gn:BSU10680" /db_xref="EnsemblGenomes-Tr:CAB12908" /db_xref="GOA:O06717" /db_xref="InterPro:IPR024496" /db_xref="SubtiList:BG13091" /db_xref="UniProtKB/Swiss-Prot:O06717" /translation="MLKRISRIRLVKFNSLGIASVFQVGDTNEIDMSVKVFAVQRSLS TFYHNEGSFNKKEYQIFQQQAVKPLPETGVQSAFCHEVPAIYVRSIKIQGVSASSVLH AGSASLIRGDARLKHIRQIQSPRSQSPAKNI*" /label="gerPE CDS" gene complement(1067188..1067589) /gene="gerPE" /locus_tag="BSU_10680" /old_locus_tag="BSU10680" /label="gerPE gene" CDS complement(1067589..1067765) /gene="gerPD" /locus_tag="BSU_10690" /old_locus_tag="BSU10690" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388950.1" /db_xref="EnsemblGenomes-Gn:BSU10690" /db_xref="EnsemblGenomes-Tr:CAB12909" /db_xref="GOA:O06718" /db_xref="InterPro:IPR017257" /db_xref="SubtiList:BG13092" /db_xref="UniProtKB/Swiss-Prot:O06718" /translation="MIFTVINRSLEVGDIRMNGVSSSSVFHIGDTESIYLSSIFDTPP ESLIIGPFAPLAPE*" /label="gerPD CDS" gene complement(1067589..1067765) /gene="gerPD" /locus_tag="BSU_10690" /old_locus_tag="BSU10690" /label="gerPD gene" CDS complement(1067762..1068379) /gene="gerPC" /locus_tag="BSU_10700" /old_locus_tag="BSU10700" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388951.1" /db_xref="EnsemblGenomes-Gn:BSU10700" /db_xref="EnsemblGenomes-Tr:CAB12910" /db_xref="GOA:O06719" /db_xref="InterPro:IPR019673" /db_xref="SubtiList:BG13093" /db_xref="UniProtKB/Swiss-Prot:O06719" /translation="MYDQSVSSYLQNLNSFVQQQAIHIQQLERQLKEIQTEMNTMKQR PATTIERVEYKFDQLKIERLDGTLNIGLNPTDPNSVQNFDVSQSTPQIGMMQQEESAQ LMQQIRQNVDMYLTEEIPDILEQLENQYDSRLDDTNRHHVIEDIRKQMDSRIHYYMSH IKKEENTPPAQYAEHIAEHVKRDVIRAVEHFLEHIPSEMKGDEQA*" /label="gerPC CDS" gene complement(1067762..1068379) /gene="gerPC" /locus_tag="BSU_10700" /old_locus_tag="BSU10700" /label="gerPC gene" CDS complement(1068402..1068635) /gene="gerPB" /locus_tag="BSU_10710" /old_locus_tag="BSU10710" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388952.2" /db_xref="EnsemblGenomes-Gn:BSU10710" /db_xref="EnsemblGenomes-Tr:CAB12911" /db_xref="GOA:O06720" /db_xref="InterPro:IPR024255" /db_xref="SubtiList:BG13094" /db_xref="UniProtKB/Swiss-Prot:O06720" /translation="MNFYINQTIQINYLRLESISNSSILQIGSAGSIKSLSNLYNTGS YVEPAPEVSGSGQPLQLQEPDTGSLVPLQPPGR*" /label="gerPB CDS" gene complement(1068402..1068635) /gene="gerPB" /locus_tag="BSU_10710" /old_locus_tag="BSU10710" /label="gerPB gene" CDS complement(1068650..1068871) /gene="gerPA" /locus_tag="BSU_10720" /old_locus_tag="BSU10720" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388953.1" /db_xref="EnsemblGenomes-Gn:BSU10720" /db_xref="EnsemblGenomes-Tr:CAB12912" /db_xref="GOA:O06721" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13095" /db_xref="UniProtKB/Swiss-Prot:O06721" /translation="MPAIVGAFKINAIGTSGVVHIGDCITISPQAQVRTFAGAGSFNT GDSLKVMNYQNATNVYDNDAVDQPIVANA*" /label="gerPA CDS" gene complement(1068650..1068871) /gene="gerPA" /locus_tag="BSU_10720" /old_locus_tag="BSU10720" /label="gerPA gene" S_feature complement(1068872..1068958) /Source="Nicolas_S_feature" /locus_tag="new_1150428_1150514_c" /HighExp="S6, S8, S7, S5, BT, B36, B60, G/S, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S380" promotor_-35 1068886..1068892 /Source="Nicolas_upshift_promotors" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1068906..1068925 /Source="Nicolas_upshift_promotors" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1068908..1069563 /Source="Nicolas_S_feature" /locus_tag="new_1150464_1151119" /HighExp="Salt, BC, Sw, S8, Heat, M9-stat, S7, Etha, BMM, Lbtran" /AntisenseName="yisI" /AntisenseCor="3.97396613023396E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="0.17396" /TUshortSig="SigA" /TUshortPSig="0.733" /TUlongSig="NA" /TUlongPSig="NA" /label="S381" upshifts 1068908 /Source="Nicolas_upshifts" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1068945..1068964) /Source="Nicolas_upshift_promotors" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1068958) /Source="Nicolas_upshifts" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1068960..1069089) /Source="Nicolas_S_feature" /locus_tag="new_1150516_1150645_c" /HighExp="S6, S8, S7, T5.0H, T3.30H, T4.0H, S5, T3.0H, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S382" promotor_-35 complement(1068977..1068986) /Source="Nicolas_upshift_promotors" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1069091..1069293) /Source="Nicolas_S_feature" /locus_tag="new_1150647_1150849_c" /HighExp="T5.0H, T4.0H, T3.30H, S6, M9-stat, T3.0H, S8, S7, T2.30H, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.976, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S383" downshifts complement(1069134) /Source="Nicolas_upshifts" /id="D581" /incds=0 /nref=13 /ntot=116 /MaxReadThrough="3.97434" /MaxDrop="3.59184" /score="13.5435041" /energy="-15.3" /TU="U865" /idTUdmin="U864" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1069294..1069464) /gene="pchI" /locus_tag="BSU_10730" /old_locus_tag="BSU10730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase (iron-metabolism related)" /protein_id="NP_388954.1" /db_xref="EnsemblGenomes-Gn:BSU10730" /db_xref="EnsemblGenomes-Tr:CAB12913" /db_xref="GOA:O06722" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13096" /db_xref="UniProtKB/Swiss-Prot:O06722" /translation="MNSKIEEMRITLIETAQKYGMNSKETIQCSQELDILLNTRIKEE MIFGRYLENSRM*" /label="pchI CDS" gene complement(1069294..1069464) /gene="pchI" /locus_tag="BSU_10730" /old_locus_tag="BSU10730" /label="pchI gene" misc_feature complement(1069508..1069527) /Source="Nicolas_upshift_promotors" /id="U864" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.386613386613387" /psig="0.976023976023976" /xcortree=2921 /SigmaFactorBS="gcttttttagtcaaattgacgaaaggcaaccttttgagccaa aaTAGGTTATACTAACGATATCctgtatttatatcaaaataaaatctagaattggaga t" /listShort="yisI, S383" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1069511) /Source="Nicolas_upshifts" /id="U864" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.386613386613387" /psig="0.976023976023976" /xcortree=2921 /SigmaFactorBS="gcttttttagtcaaattgacgaaaggcaaccttttgagccaa aaTAGGTTATACTAACGATATCctgtatttatatcaaaataaaatctagaattggaga t" /listShort="yisI, S383" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1069513..1069609) /Source="Nicolas_S_feature" /locus_tag="new_1151069_1151165_c" /HighExp="S6, S8, S7, S5, BT, Pyr, G/S, Glucon, SMMPr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S384" downshifts 1069520 /Source="Nicolas_upshifts" /id="D582" /incds=0 /nref=3 /ntot=54 /MaxReadThrough="4.52913" /MaxDrop="3.35342" /score="12.6645711" /energy="-10.3" /TU="U862" /idTUdmin="U862" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" S_feature 1069565..1069729 /Source="Nicolas_S_feature" /locus_tag="new_1151121_1151285" /HighExp="Salt, S8, S7, BC, Heat, H2O2, Sw, Oxctl, MG-0.2, MG-0.1" /AntisenseName="yisJ" /AntisenseCor="0.24461808844813801" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.733" /TUlongSig="NA" /TUlongPSig="NA" /label="S385" CDS complement(1069610..1070533) /gene="yisJ" /locus_tag="BSU_10740" /old_locus_tag="BSU10740" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein, CotH paralog" /protein_id="NP_388955.1" /db_xref="EnsemblGenomes-Gn:BSU10740" /db_xref="EnsemblGenomes-Tr:CAB12914" /db_xref="GOA:O06723" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG13097" /db_xref="UniProtKB/Swiss-Prot:O06723" /translation="MERVHLFFHREQLKRKGTAKGLFVTDRSVSPILLTQRDRAEKAS YEISWEKSLLGERTLFLNAEQDDPSLMRRRLAYCFFDQIGVPAPVASYSFLTINGQPE GIYLNIKNHQPAGKRSYGVKTADPRVPLSLFNNDSSAFLHEFFILIRTAGDDELAERI KLYLDVKLFFLWLIGNTCTNQGFYYTFCLNESGRLYVSPMETRSLAVQEWYEEDPLLT KGKTLSSRLLSIPAFRSQYHTLMKNVLKRSFTIERLSPLINEWHLDICQSAADDPFIK KSPFQIEKEQTNILREIEERQDFLQAHLARL*" /label="yisJ CDS" gene complement(1069610..1070533) /gene="yisJ" /locus_tag="BSU_10740" /old_locus_tag="BSU10740" /label="yisJ gene" promotor_-10 complement(1070555..1070574) /Source="Nicolas_upshift_promotors" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="promotor_-10" upshifts complement(1070566) /Source="Nicolas_upshifts" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="upshifts" promotor_-35 complement(1070588..1070597) /Source="Nicolas_upshift_promotors" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="promotor_-35" promotor_-35 1070617..1070625 /Source="Nicolas_upshift_promotors" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="promotor_-35" promotor_-10 1070637..1070655 /Source="Nicolas_upshift_promotors" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="promotor_-10" upshifts 1070642 /Source="Nicolas_upshifts" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="upshifts" CDS 1070688..1071593 /gene="mblK" /locus_tag="BSU_10750" /old_locus_tag="BSU10750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16847875, 27215790, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16847875, 27215790, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydrolase/isomerase involved in remodelling the bacterial envelope" /protein_id="NP_388956.1" /db_xref="EnsemblGenomes-Gn:BSU10750" /db_xref="EnsemblGenomes-Tr:CAB12915" /db_xref="GOA:O06724" /db_xref="InterPro:IPR011234" /db_xref="InterPro:IPR036663" /db_xref="SubtiList:BG13098" /db_xref="UniProtKB/Swiss-Prot:O06724" /translation="MKFATGELYNRMFVGLIIDDEKIMDLQKAEKKLFELETIPGSLI ECIAEGDKFVAHARQLAEWAKKPNDELGSFMYSLSEVKLHAPIPKPSKNIICIGKNYR DHAIEMGSEADIPEHPMVFTKSPVTVTGHGDIVKSHEEVTSQLDYEGELAVVIGKSGT RISKEDAYDHVFGYTIVNDITARDLQKRHKQFFIGKSLDTTCPMGPVLVHKSSIQEPE RLKVETRVNGELRQSGSASDMIFSIPELIETLSKGMTLEAGDIIATGTPSGVGKGFTP PKFLRSGDKIDITIDPIGTLSNQIG*" /label="mblK CDS" gene 1070688..1071593 /gene="mblK" /locus_tag="BSU_10750" /old_locus_tag="BSU10750" /label="mblK gene" S_feature 1071594..1071674 /Source="Nicolas_S_feature" /locus_tag="new_1153150_1153230" /HighExp="S2, Lbstat, S1, Etha, SMMPr, M0t90, M40t90, LoTm, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S386" promotor_-35 1071644..1071647 /Source="Nicolas_upshift_promotors" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1071664..1071683 /Source="Nicolas_upshift_promotors" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1071676 /Source="Nicolas_upshifts" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="upshifts" CDS 1071709..1072065 /gene="yisL" /locus_tag="BSU_10760" /old_locus_tag="BSU10760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27215790; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388957.1" /db_xref="EnsemblGenomes-Gn:BSU10760" /db_xref="EnsemblGenomes-Tr:CAB12916" /db_xref="GOA:O06725" /db_xref="InterPro:IPR010899" /db_xref="SubtiList:BG13099" /db_xref="UniProtKB/Swiss-Prot:O06725" /translation="MTHLHITTWVVALILLFVSYSLYSSGSAKGAKITHMILRLFYIL IILTGAELFVRFANWNGEYAGKMILGIITIGLMEMLLIRKKKEKSTGGLWVGFVIVLL LTVLLGLHLPIGFQLF*" /label="yisL CDS" gene 1071709..1072065 /gene="yisL" /locus_tag="BSU_10760" /old_locus_tag="BSU10760" /label="yisL gene" downshifts 1071962 /Source="Nicolas_upshifts" /id="D583" /incds=1 /nref=1 /ntot=44 /MaxReadThrough="4.28837" /MaxDrop="2.46999" /score="41.4247437" /energy="-11.7" /TU="U866,U867" /idTUdmin="U867" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 1072053 /Source="Nicolas_upshifts" /id="D584" /incds=0 /nref=17 /ntot=162 /MaxReadThrough="3.06092" /MaxDrop="3.41506" /score="41.4247437" /energy="-11.7" /TU="U866" /idTUdmin="U867" /TUdmin=3 /isTUend="TRUE" /label="downshifts" upshifts 1072186 /Source="Nicolas_upshifts" /id="U868" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.486513486513487" /psig="0.732267732267732" /xcortree=2782 /SigmaFactorBS="atattccaaatcatttaaaataaccttaaaattccctgtaag cggtatctcgtcctatgaaatTATGATACCTTCAAGGAGATtcattattttgcaggag g" /listShort="wprA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1072189..1072208 /Source="Nicolas_upshift_promotors" /id="U868" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.486513486513487" /psig="0.732267732267732" /xcortree=2782 /SigmaFactorBS="atattccaaatcatttaaaataaccttaaaattccctgtaag cggtatctcgtcctatgaaatTATGATACCTTCAAGGAGATtcattattttgcaggag g" /listShort="wprA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1072233..1074917 /gene="wprA" /locus_tag="BSU_10770" /old_locus_tag="BSU10770" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9004506, 9675284, 10336490, 15205417, 17269748, 21636651, 23180473, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9004506, 9675284, 10336490, 15205417, 17269748, 21636651, 23180473, 25313396; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated protease" /protein_id="NP_388958.1" /db_xref="EnsemblGenomes-Gn:BSU10770" /db_xref="EnsemblGenomes-Tr:CAB12917" /db_xref="GOA:P54423" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034084" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG11846" /db_xref="UniProtKB/Swiss-Prot:P54423" /translation="MKRRKFSSVVAAVLIFALIFSLFSPGTKAAAAGAIDQAAALENG KEQTGAMKEPEQVKWYKVTPGATDIQKNSHMALTVKSDSVLNVSVYPSKEKALKDETF EMYRSFTAEDGKSEVIFPYAWSGPYYVKVEYLGEEEPEDGGTAEAAAEAKYTIGYKGT KKQPSDLEEEEACPVEMSVDQKKSGKGILDKLRSIRDEQLSQTAEGKELTSLYYKAAP FIVAKLALNKTARNEIYQDLVTLKPLFDDVSENGASSSYKVTEKDQKAINRLYDKALQ SVPSFLKEEIKKQADRLNMKQLQGKTAGAILTENNIAAKSEVQTTKVIFKVKDNKSLS SVHNEMKGFSASAQSKKDISNVKKAKKLFDNLYSFELPKDEKQNGAYTASAKRVKSAA ATLSKMSNVEFAEPVQEYKSLANDIQYPYQWPLKNNGENGGVKNADVKYEPANTLLSK RKLNDTLIAVVDTGVDSTLADLKGKVRTDLGHNFVGRNNNAMDDQGHGTHVAGIIAAQ SDNGYSMTGLNAKAKIIPVKVLDSAGSGDTEQIALGIKYAADKGAKVINLSLGGGYSR VLEFALKYAADKNVLIAAASGNDGENALSYPASSKYVMSVGATNRMDMTADFSNYGKG LDISAPGSDIPSLVPNGNVTYMSGTSMATPYAAAAAGLLFAQNPKLKRTEVEDMLKKT ADDISFESVDGGEEELYDDYGDPIEIPKTPGVDWHSGYGRLNVMKAVSAADLQLKVNK LESTQTAVRGSAKEGTLIEVMNGKKKLGSAKAGKDNAFKVNIATQKQDQVLYLKATKG DAKTSYKVVVVKGKPSGTPKVNAVKTKDTAVKGKANSKAMIRVKNKSKKVIASAKADA KGTFSVKIKKQKAGTVLYVTAVDTDKKESKEAKVVVEK*" /label="wprA CDS" gene 1072233..1074917 /gene="wprA" /locus_tag="BSU_10770" /old_locus_tag="BSU10770" /label="wprA gene" downshifts complement(1072401) /Source="Nicolas_upshifts" /id="D585" /incds=1 /nref=2 /ntot=155 /MaxReadThrough="0.14981" /MaxDrop="3.98572" /score="9.01750245" /energy="-8" /TU="NA" /idTUdmin="U869" /TUdmin=2563 /isTUend="FALSE" /label="downshifts" downshifts 1074909 /Source="Nicolas_upshifts" /id="D586" /incds=0 /nref=239 /ntot=267 /MaxReadThrough="1.55031" /MaxDrop="8.31576" /score="36.3638154" /energy="-12.3" /TU="NA" /idTUdmin="U868" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1074948..1075535) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388959.1" /db_xref="EnsemblGenomes-Gn:BSU10780" /db_xref="EnsemblGenomes-Tr:CAB12918" /db_xref="InterPro:IPR024488" /db_xref="SubtiList:BG12239" /db_xref="UniProtKB/Swiss-Prot:O06727" /translation="MKKKETAWMKRKQLLYTEERKWEYGTILIEDGICLIENGEGDIL LADSLQHSPIWIHHKGKWEQAGFQDKLVLACGAENISLSGGERIRYEKSVKRPLMALL DSLDDETFLAFLQHLHSFGLSVFDCVFSYNKGVFSNTSAGQGVSFYHFSNDTAQCAMQ HHYNYSSEGTGDRFEWTASNGKRSIMYTAVQRGRK*" /label="yisN CDS" gene complement(1074948..1075535) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /label="yisN gene" promotor_-10 complement(1075550..1075569) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1075569) /Source="Nicolas_upshifts" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1075585..1075587) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1075590..1075596 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1075608 /Source="Nicolas_upshifts" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1075611..1075629 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1075614..1075680 /Source="Nicolas_S_feature" /locus_tag="new_1157170_1157236" /HighExp="S6, S5, S7, S8, B36, S4, BT, G/S, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S387" CDS 1075681..1077525 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /EC_number="6.3.5.4" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (sporulation related)" /protein_id="NP_388960.2" /db_xref="EnsemblGenomes-Gn:BSU10790" /db_xref="EnsemblGenomes-Tr:CAB12919" /db_xref="GOA:O05272" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG12240" /db_xref="UniProtKB/Swiss-Prot:O05272" /translation="MCGITGWVDFKKQLVQEKQTMDRMTDTLSKRGPDDSNVWGEHHV LFGHKRLAVVDIEGGRQPMACTYKGDTYTIIYNGELYNTEDLRKELRARGHQFERTSD TEVLLHSYIEWQEDCVDHLNGIFAFAVWDEKRNLLFAARDRLGVKPFFYTKEGSSFLF GSEIKAILAHPDIKARVDRTGLSEIFGLGPSRTPGTGIFKGIKEIRPAHALTFSKDGL NIWRYWNVESEKHTDSFDDTVANVRSLFQDAVTRQLVSDVPVCTFLSGGLDSSAITAI AAGHFEKEGKAPLHTYSIDYEENDKYFQASAFQPNDDGPWIEKMTEAFGTTHHKCVIS QKDLVDHLEEAVLVKDLPGMADVDSSLLWFCREIKKDFVVSLSGECADEIFGGYPWFH TADVESGFPWMRSTEERIKLLSDSWQKKLNLKEYVNAKYEETLAETPLLDGETGVDKA RRQLFYLNMLWFMTNLLDRKDRMSMGASLEVRVPFADHRLVEYVWNIPWEMKMHDNRE KGILRKALEGILPDDILYRKKSPYPKTHHPEYTKGVSEWLKTIRSQKDSVLHTLLDRK QLDQLLETEGSSFKVPWFGQLMKGPQLIAHLAQIHTWFEAYRIDIDER*" /label="asnO CDS" gene 1075681..1077525 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /label="asnO gene" S_feature 1077526..1077593 /Source="Nicolas_S_feature" /locus_tag="new_1159082_1159149" /HighExp="S6, S5, S7, B36, BT, S8, S4, B60, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S388" downshifts 1077550 /Source="Nicolas_upshifts" /id="D587" /incds=0 /nref=12 /ntot=43 /MaxReadThrough="3.29969" /MaxDrop="4.67478" /score="3.55879494" /energy="-14.8" /TU="U870" /idTUdmin="U870" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(1077655..1078134) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation related)" /protein_id="YP_054576.1" /db_xref="EnsemblGenomes-Gn:BSU10800" /db_xref="EnsemblGenomes-Tr:CAE01451" /db_xref="GOA:Q7WY73" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="PDB:2QE9" /db_xref="SubtiList:BG14187" /db_xref="UniProtKB/Swiss-Prot:Q7WY73" /translation="MMKFFEYNWQVRDQWFTWCHQLTTEELLKNRLGGVENILYTLFH IIDVEYSWIRAIQGKEDIAVQFADYQTLNKVKSLSNTFRTEIIDVLQTHSDQIKDELV SVPWETGVLYTRDEILHHIIAHEIHHIGQLSVWARELKLSPVSASFIGRTLKPIHSY* " /label="yizA CDS" gene complement(1077655..1078134) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /label="yizA gene" upshifts complement(1078154) /Source="Nicolas_upshifts" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1078158..1078176) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1078187..1078195) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1078326..1078330 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1078343 /Source="Nicolas_upshifts" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1078345..1078364 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1078366..1079190 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /EC_number="3.6.1.27" /experiment="publication(s) with functional evidences, PMID:23295493, 25308276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23295493, 25308276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate phosphatase" /protein_id="NP_388961.1" /db_xref="EnsemblGenomes-Gn:BSU10810" /db_xref="EnsemblGenomes-Tr:CAB12920" /db_xref="GOA:O06728" /db_xref="InterPro:IPR002060" /db_xref="InterPro:IPR008949" /db_xref="PDB:3WE9" /db_xref="SubtiList:BG12241" /db_xref="UniProtKB/Swiss-Prot:O06728" /translation="MIHRSEKMKEIKEAYQQCGQIVGEYAPACFKALSYLPLKQRQAS WAVLSFCHTAASADEKVLPAFEAKADHVYQRTNNGKQHLWKAFDHAYRTFTLESEPFR EFIAAQKEDAKPYDDLDELLMYAYRTGGAAGLMLLPILTRRKQDQLKQAAVSLGLAIQ LVRFLSDLGTDQQKNRIPRQVMQQFGYTEADLQKGTVNKAFTMTWEYIAFEAEAYLEE CQDALPLFPQYSQKTVKAALHLHRAVLEKIRAKQHDVFQYHFALTETEVKQILSDI*" /label="farP CDS" gene 1078366..1079190 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /label="farP gene" promotor_-35 1078578..1078584 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1078599..1078617 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1078606 /Source="Nicolas_upshifts" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1079200..1080650 /Source="Nicolas_S_feature" /locus_tag="new_1160756_1162206" /HighExp="Salt, Etha, Sw, Cold, G150, G180, G135, LBGtran, Heat, Paraq" /AntisenseName="yisQ" /AntisenseCor="0.19511630802652" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S389" CDS complement(1079220..1080587) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na(+)-driven efflux transporter" /protein_id="NP_388962.1" /db_xref="EnsemblGenomes-Gn:BSU10820" /db_xref="EnsemblGenomes-Tr:CAB12921" /db_xref="GOA:O07940" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG12242" /db_xref="UniProtKB/Swiss-Prot:O07940" /translation="MKQAVFKSTALKKPADKTFSLFSLTWPIFIEVSLYMFMGNADTL MLSQYSDNSVAAVGVSNQILNLIIVMFSFIATGTTVIISQFLGSRQKKEAMEVAYVSI GANFFISLAISAVVFFAAVPLLHMMGLSDALMPDAKVFLQVVGGLSFIQALIMTFSAI LKSYGYTKDTMFVTIGMNILNIAGNFVVIFGLFGFPVLGVAGVAMSTSIARVIGLIAM IVIVNKRIQLKMSLKKVFHMHKEHLRKLLKIGIPSAGEQLSYNLSQMIVTYFIAIMGA QALTTKVYTQNITMFILLFGTAISQGTQILIGRYIGGKQFDAAYERCMKSLYWALGIA AATSVLMTIFSKDLIGLFTQSPDIIATASLLIAMTIILEPGRSFNVIIINSLRAAGDA KFPVYMAMISMWGIGLPLAYLFGIHLGFGLAGIWISFIADEWVRGILMYRRWRSRIWI QKGMA*" /label="yisQ CDS" gene complement(1079220..1080587) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /label="yisQ gene" promotor_-35 1080619..1080626 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1080640..1080659 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1080652 /Source="Nicolas_upshifts" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="upshifts" CDS 1080711..1081574 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388963.1" /db_xref="EnsemblGenomes-Gn:BSU10830" /db_xref="EnsemblGenomes-Tr:CAB12922" /db_xref="GOA:P40331" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11064" /db_xref="UniProtKB/Swiss-Prot:P40331" /translation="MPRILFTVPPFPVFIAAGEGVFKKGETHVKRVFSVFDLIYVKQG TLYITENETSFSVEGGEYILLSPGLEHYGTKGSDEATSYYWLHFDEHRYEFTAKGGSN WSELQQEKGSFEELARYGLALPRKGKVQRPQFMAQQFEKLIDYSAENSDLPLRKQILF EELMLHLQKEAFQIPSAKERVAWEAARYLQEHYKEKTTIKDLSLALHYHQDYVSRCMQ QVLGVTPAQYTNRVRMTEAKRLLSSTNDKMGVIAETVGMEDPTYFSKLFKQIEGISPI EYRKIVSRKVQ*" /label="yisR CDS" gene 1080711..1081574 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /label="yisR gene" CDS 1081592..1082605 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8407808, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8407808, 23504016, 28693424; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of iolX (LacI family)" /protein_id="NP_388964.1" /db_xref="EnsemblGenomes-Gn:BSU10840" /db_xref="EnsemblGenomes-Tr:CAB12923" /db_xref="GOA:P37947" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10847" /db_xref="UniProtKB/Swiss-Prot:P37947" /translation="MKTTIYDVAKAAGVSITTVSRVINNTGRISDKTRQKVMNVMNEM AYTPNVHAAALTGKRTNMIALVAPDISNPFYGELAKSIEERADELGFQMLICSTDYDP KKETKYFSVLKQKKVDGIIFATGIESHDSMSALEEIASEQIPIAMISQDKPLLPMDIV VIDDVRGGYEAAKHLLSLGHTNIACIIGDGSTTGEKNRIKGFRQAMEEAGVPIDESLI IQTRFSLESGKEEAGKLLDRNAPTAIFAFNDVLACAAIQAARIRGIKVPDDLSIIGFD NTILAEMAAPPLTTVAQPIKEMGRSVIELLAEAIEGKRKAKQKIVLPPELVVRHSTSP LNT*" /label="iolQ CDS" gene 1081592..1082605 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /label="iolQ gene" downshifts 1082588 /Source="Nicolas_upshifts" /id="D588" /incds=0 /nref=13 /ntot=204 /MaxReadThrough="0.51227" /MaxDrop="3.29173" /score="25.1260914" /energy="-9.6" /TU="NA" /idTUdmin="U874" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-35 1082657..1082664 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1082679..1082698 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1082698..1082813 /Source="Nicolas_S_feature" /locus_tag="new_1164254_1164369" /HighExp="Lbstat, M40t90, M0t90, BI, G150, dia0, Mt0, Lbexp, Lbtran, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S390" upshifts 1082698 /Source="Nicolas_upshifts" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="upshifts" CDS 1082814..1083842 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /EC_number="1.1.1.370" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11160890, 20133360, 23109554, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 20133360, 23109554, 23504016, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NAD(+))" /protein_id="NP_388965.1" /db_xref="EnsemblGenomes-Gn:BSU10850" /db_xref="EnsemblGenomes-Tr:CAB12924" /db_xref="GOA:P40332" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11065" /db_xref="UniProtKB/Swiss-Prot:P40332" /translation="MEHQVRCAVLGLGRLGYYHAKNLVTSVPGAKLVCVGDPLKGRAE QVARELGIEKWSEDPYEVLEDPGIDAVIIVTPTSTHGDMIIKAAENGKQIFVEKPLTL SLEESKAASEKVKETGVICQVGFMRRFDPAYADAKRRIDAGEIGKPIYYKGFTRDQGA PPAEFIKHSGGIFIDCSIHDYDIARYLLGAEITSVSGHGRILNNPFMEQYGDVDQALT YIEFDSGAAGDVEASRTSPYGHDIRAEVIGTEGSIFIGTLRHQHVTILSAKGSSFDII PDFQTRFHEAYCLELQHFAECVRNGKTPIVTDIDATINLEVGIAATNSFRNGMPVQLD VKRAYTGM*" /label="iolX CDS" gene 1082814..1083842 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /label="iolX gene" downshifts 1083864 /Source="Nicolas_upshifts" /id="D589" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="0.33001" /MaxDrop="3.45406" /score="8.69111487" /energy="-13.4" /TU="NA" /idTUdmin="U875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1083893..1084402) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25651892; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative enzyme regulator of activity" /protein_id="NP_388966.2" /db_xref="EnsemblGenomes-Gn:BSU10860" /db_xref="EnsemblGenomes-Tr:CAB12925" /db_xref="GOA:O07939" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12243" /db_xref="UniProtKB/Swiss-Prot:O07939" /translation="MTDAKQFYDYHSWANKKIFTHIENLPEETAYQEVKSVFPSVSDV LLHMCRADYIWLNVLSGVAYQEIIDSAGKLQSAQGNMAAIKQHAAELESQYHDFFSRQ TDLEQTFTMQHPKLGTLESTYADTILHVVNHGTYHRGNVTAMLRQLDHSGVPTDYMYY LYEKRESKG*" /label="yisT CDS" gene complement(1083893..1084402) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /label="yisT gene" downshifts complement(1083912) /Source="Nicolas_upshifts" /id="D590" /incds=0 /nref=81 /ntot=251 /MaxReadThrough="-0.0416600000000003" /MaxDrop="7.15629" /score="27.2292301" /energy="-13.4" /TU="NA" /idTUdmin="U876" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1084415..1084433) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1084431) /Source="Nicolas_upshifts" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1084445..1084453) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1084452..1085114) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid related metabolite efflux transporter" /protein_id="NP_388967.1" /db_xref="EnsemblGenomes-Gn:BSU10870" /db_xref="EnsemblGenomes-Tr:CAB12926" /db_xref="GOA:O06730" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG13100" /db_xref="UniProtKB/Swiss-Prot:O06730" /translation="MTISLMIEKKCERSFFSMNAIIHGIVLAFGLILPLGVQNVFIFQ QGALQKHIWRALPAVISASVCDTLLIVLAVAGVSVIVQELPVFETVMMAGGFLFLLYM GWVTWNIRPNTSQNEKHTFTPKKQAAFAAAVSLLNPHAILDTIGVIGTSSLQYSGLEK WLFMAACIAVSWIWFISLAIAGRLFQTIDTSGRLMLIVNKCSAAVMWAAAGYFGVSLF CN*" /label="yisU CDS" gene complement(1084452..1085114) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /label="yisU gene" promotor_-35 1085133..1085139 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1085153..1085172 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1085162 /Source="Nicolas_upshifts" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="upshifts" CDS 1085181..1086635 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 19383706; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388968.2" /db_xref="EnsemblGenomes-Gn:BSU10880" /db_xref="EnsemblGenomes-Tr:CAB12927" /db_xref="GOA:Q796Q6" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13101" /db_xref="UniProtKB/Swiss-Prot:Q796Q6" /translation="MTLSQWQPSRKSDVPLHRQIEQYMKDKILHGEWAVGTKIPSQRT LADMFQVNRSTVTAAIDELTSQGLLEGRKGGGTKVVNSTWSVLTAEPPLDWSDYVRSG IHRANSSIIQAINQNEPRADIIRLGTGELSPDLVPADTIGRMFQQINPGVLSLGYEQP KGNRQLREAVADHLKGKKIHVSPSAILIVSGALQALQLISIGLLKRDSVILTEKPSYL QSLHVFQSAGMRLRGLPMDDEGVKAGLVSSNRKQYGGQLLYTIPSFHNPTGTVMSEQR RKEIISLSKKEQMPIIEDDAYGDLWFEEKPPQPLKAMDHEGNILYLGAFSKTVSPGLR IGWLAGPEPVIERLADIKMQTDYGSSGLSQWAAAEWLSQGYYEEHLTWVRRKLKERRD AAVHFLERYAGDIATWRIPAGGFYIWVTFHKNLPVSRFFYELLKRQVLVNPGYIYDGE DRNSIRLSYSYASLGDLETGIKAAAETARRLMMS*" /label="yisV CDS" gene 1085181..1086635 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /label="yisV gene" S_feature complement(1086490..1086642) /Source="Nicolas_S_feature" /locus_tag="new_1168046_1168198_c" /HighExp="Diami, Sw, C90, LBGstat, dia15, Paraq, dia5, BC, M40t45, Oxctl" /AntisenseName="yisV" /AntisenseCor="0.69858995161852" /AntisenseRegPval="-40" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S391" downshifts complement(1086525) /Source="Nicolas_upshifts" /id="D591" /incds=1 /nref=2 /ntot=84 /MaxReadThrough="2.36735" /MaxDrop="2.81041" /score="-5.131548" /energy="-17.3" /TU="NA" /idTUdmin="U879" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1086643..1087281) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388970.1" /db_xref="EnsemblGenomes-Gn:BSU10890" /db_xref="EnsemblGenomes-Tr:CAB12929" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG13103" /db_xref="UniProtKB/Swiss-Prot:O06733" /translation="MNKIAIQKPNIPENLQTADFHDAVTQDDVISMHLFEDCTICGED IERLCVEKTVFRNVVFIDVSFRHIELTDVIFEKCDLSNADFSGAVIHRTSVKQSKMVG MNVAEATLRNVSFEECHGHFSSFSYSNMKQVRFDHCALMQSECSDTVLQQTHFDGCEL EGASFTGTSLQNMDISTCRFEQLHVSLDKLKGCKIAPEHAIAFARALGAVIV*" /label="yisX CDS" gene complement(1086643..1087281) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /label="yisX gene" S_feature complement(1087282..1087416) /Source="Nicolas_S_feature" /locus_tag="new_1168838_1168972_c" /HighExp="Diami, dia15, dia5, C90, BC, Paraq, LBGstat, Lbtran, HiOs, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S392" promotor_-35 1087330..1087335 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1087351..1087369 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1087352 /Source="Nicolas_upshifts" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="upshifts" S_feature 1087362..1087486 /Source="Nicolas_S_feature" /locus_tag="new_1168918_1169042" /HighExp="S6, S5, S8, S7, S4, BT, B36, S3, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S393" promotor_-10 complement(1087402..1087421) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1087416) /Source="Nicolas_upshifts" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1087436..1087443) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1087487..1088293 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl hydrolase or peroxidase" /protein_id="NP_388971.1" /db_xref="EnsemblGenomes-Gn:BSU10900" /db_xref="EnsemblGenomes-Tr:CAB12930" /db_xref="GOA:O06734" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13104" /db_xref="UniProtKB/Swiss-Prot:O06734" /translation="MGHYIKTEEHVTLFVEDIGHGRPIIFLHGWPLNHKMFEYQMNEL PKRGFRFIGVDLRGYGQSDRPWEGYDYDTMADDVKAVIYTLQLENAILAGFSMGGAIA IRYMARHEGADVDKLILLSAAAPAFTKRPGYPYGMRKQDIDDMIELFKADRPKTLADL GKQFFEKKVSPELRQWFLNLMLEASSYGTIHSGIALRDEDLRKELAAIKVPTLILHGR KDRIAPFDFAKELKRGIKQSELVPFANSGHGAFYEEKEKINSLIAQFSNS*" /label="yisY CDS" gene 1087487..1088293 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /label="yisY gene" downshifts 1088286 /Source="Nicolas_upshifts" /id="D592" /incds=0 /nref=4 /ntot=24 /MaxReadThrough="2.64682" /MaxDrop="5.60718" /score="8.70914085" /energy="-6.5" /TU="NA" /idTUdmin="U878" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1088321..1088920) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /EC_number="2.7.1.25" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenylylsulfate kinase" /protein_id="NP_388972.1" /db_xref="EnsemblGenomes-Gn:BSU10910" /db_xref="EnsemblGenomes-Tr:CAB12931" /db_xref="GOA:O06735" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13105" /db_xref="UniProtKB/Swiss-Prot:O06735" /translation="MTHNPNIIWHPAAISKSDRQSLNGHKSCVLWFTGLSGSGKSVLA NAVDEKLYRKGIQSYVLDGDNIRHGLNKDLGFQTGDRIENIRRIGEVAKLFVDSGQMI LTAFISPFREDRDMVRALFPKGEFFEIYVKCPLHVCEQRDPKGLYKKARNGEIKHFTG IDSPYEAPLSPDFIIESDQTSISDGADLIINALQNRGII*" /label="yisZ CDS" gene complement(1088321..1088920) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /label="yisZ gene" downshifts complement(1088340) /Source="Nicolas_upshifts" /id="D593" /incds=0 /nref=35 /ntot=44 /MaxReadThrough="1.69999" /MaxDrop="6.8011" /score="17.1506785" /energy="-7.3" /TU="NA" /idTUdmin="U880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1088917..1090086) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /EC_number="2.7.7.4" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfate adenylyltransferase" /protein_id="NP_388973.2" /db_xref="EnsemblGenomes-Gn:BSU10920" /db_xref="EnsemblGenomes-Tr:CAB12932" /db_xref="GOA:O06736" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13106" /db_xref="UniProtKB/Swiss-Prot:O06736" /translation="MNGNEPHGGVLINRCDPACHFEGCACQAELDQLALSDLELIAIG GYSPLTGFLGEKDYHSVVKEMRLANGLPWSLPITLPVGEKTARQLSAGDHVKLVKDGV TYGMITVTDIYQPDKTQEALSVFKTNDPAHPGVKKLLARPDYYIGGPITVSSLPDKSF EQFYATPAETRAAFQKLGWKTIVGFQTRNPVHRAHEYIQKTALETVDGLLLHPLVGET KSDDIPSDIRMESYQALLNHYYPKDRVMLSVFPAAMRYAGPREAIFHALVRKNYGCTH FIVGRDHAGVGSYYGTYDAQNIFQSFTEEELGIKPLFFEHSFYCRKCGNMGTSKTCPH SPRDHIHLSGTKVRELLRQGKKPPKEFSRPEVAAVLIKGLHQQPVAIKQNSGELQ*" /label="yitA CDS" gene complement(1088917..1090086) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /label="yitA gene" S_feature complement(1090087..1090198) /Source="Nicolas_S_feature" /locus_tag="new_1171643_1171754_c" /HighExp="S6, S7, S8, BT, S5, B36, G/S, Pyr, SMMPr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S394" CDS complement(1090199..1090909) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospho-adenylylsulfate reductase" /protein_id="NP_388974.2" /db_xref="EnsemblGenomes-Gn:BSU10930" /db_xref="EnsemblGenomes-Tr:CAB12933" /db_xref="GOA:O06737" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13107" /db_xref="UniProtKB/Swiss-Prot:O06737" /translation="MNETITYDTWNDMLSKQITDQLIDELDVLKWAYRTYGEKIVYAC SFGAEGMVLLDLISKINKNAHIIFLDTGLHFQETYELIETVKERYPGFAIQMLEPELS LTEQGTKYGGELWKHNPNLCCQLRKIEPLKKHLSGMTAWISGLRRDQSPTRKHIQYVN LDQKFELIKICPLIHWTWDDVWTYIRLHNLPYNKLHDQHYPSIGCEMCTLPSPDPNDE RAGRWAGREKTECGLHQE*" /label="yitB CDS" gene complement(1090199..1090909) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /label="yitB gene" promotor_-10 complement(1090953..1090972) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1090975) /Source="Nicolas_upshifts" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1090985..1090994) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1091024..1091033 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1091047..1091066 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1091058 /Source="Nicolas_upshifts" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="upshifts" CDS 1091094..1091780 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /EC_number="3.1.3.71" /function="15.7: Sporulation and germination" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3346220, 11830598, 15383836, 16341843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho,3-sulfolactate phosphatase (sporulation related)" /protein_id="NP_388975.1" /db_xref="EnsemblGenomes-Gn:BSU10940" /db_xref="EnsemblGenomes-Tr:CAB12934" /db_xref="GOA:O06738" /db_xref="InterPro:IPR005238" /db_xref="InterPro:IPR036702" /db_xref="SubtiList:BG13108" /db_xref="UniProtKB/Swiss-Prot:O06738" /translation="MPIAIYQGHHHSLAPADINIVIDVIRAFTVAHYAFIGGAKEILL VRTADEAFALKDTYPDYVLTGEEKGVGISGFDLDNSPKRMAGQNMTDKSLIQKTTNGV TAALGALNAKHLFVTGFSNAKTTAQHVKKLVANDCVINIVASHPSGDDDMACAEYIKG IIEGTNVVTAAEAIERIKGSSVAEKFFDCRQPLFDSEDIVYCTKELTGDFVMKVKQDG EVPTIERVII*" /label="slpH CDS" gene 1091094..1091780 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /label="slpH gene" CDS 1091777..1092535 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /EC_number="4.4.1.19" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11830598, 15014443, 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho-3-sulfolactate synthase" /protein_id="NP_388976.1" /db_xref="EnsemblGenomes-Gn:BSU10950" /db_xref="EnsemblGenomes-Tr:CAB12935" /db_xref="GOA:O06739" /db_xref="InterPro:IPR003830" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036112" /db_xref="PDB:1U83" /db_xref="SubtiList:BG13109" /db_xref="UniProtKB/Swiss-Prot:O06739" /translation="MNDFSLELPVRTNKPRETGQSILIDNGYPLQFFKDAIAGASDYI DFVKFGWGTSLLTKDLEEKISTLKEHDITFFFGGTLFEKYVSQKKVNEFHRYCTYFGC EYIEISNGTLPMTNKEKAAYIADFSDEFLVLSEVGSKDAELASRQSSEEWLEYIVEDM EAGAEKVITEARESGTGGICSSSGDVRFQIVDDIISSDIDINRLIFEAPNKTLQQGFI QKIGPNVNLANIPFHDAIALETLRLGLRSDTFFL*" /label="slpS CDS" gene 1091777..1092535 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /label="slpS gene" downshifts 1092532 /Source="Nicolas_upshifts" /id="D594" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="2.37654" /MaxDrop="4.17689" /score="-1.32868938" /energy="-17.6" /TU="NA" /idTUdmin="U881" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1092580..1093209) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26335199; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388977.1" /db_xref="EnsemblGenomes-Gn:BSU10960" /db_xref="EnsemblGenomes-Tr:CAB12936" /db_xref="GOA:O06740" /db_xref="InterPro:IPR003740" /db_xref="SubtiList:BG13110" /db_xref="UniProtKB/Swiss-Prot:O06740" /translation="MAELLMKAKLTFMIVVGGVLQGLGMSLFLFPHDIPTGGAAGIAV LLHYLFQIPHGFSVWAVNVSMLFTALKWLEMRTFTGTLASITVTSVSVLIFDAVFPDI TSNLWLDLASGAVLLGLGIGLLYKYKISNGGFGALALMISIYRGGNPGTILLIMNCII FMVTASIIDWGIVIQALICQVISTRVIDFIYNIRLTSLPYLTPMYRHKK*" /label="yitE CDS" gene complement(1092580..1093209) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /label="yitE gene" promotor_-10 complement(1093243..1093261) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1093260) /Source="Nicolas_upshifts" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1093276..1093281) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1093305..1094420) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 11747447, 27994575; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enolase superfamily enzyme (isomerase /dehydratase)" /protein_id="NP_388978.1" /db_xref="EnsemblGenomes-Gn:BSU10970" /db_xref="EnsemblGenomes-Tr:CAB12937" /db_xref="GOA:O06741" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR036849" /db_xref="PDB:2GDQ" /db_xref="PDB:2GGE" /db_xref="SubtiList:BG13111" /db_xref="UniProtKB/Swiss-Prot:O06741" /translation="MKIVRIETFPLFHRLEKPYGDANGFKRYRTCYLIRIITESGIDG WGECVDWLPALHVGFTKRIIPFLLGKQAGSRLSLVRTIQKWHQRAASAVSMALTEIAA KAADCSVCELWGGRYREEIPVYASFQSYSDSPQWISRSVSNVEAQLKKGFEQIKVKIG GTSFKEDVRHINALQHTAGSSITMILDANQSYDAAAAFKWERYFSEWTNIGWLEEPLP FDQPQDYAMLRSRLSVPVAGGENMKGPAQYVPLLSQRCLDIIQPDVMHVNGIDEFRDC LQLARYFGVRASAHAYDGSLSRLYALFAQACLPPWSKMKNDHIEPIEWDVMENPFTDL VSLQPSKGMVHIPKGKGIGTEINMEIVNRYKWDGSAY*" /label="yitF CDS" gene complement(1093305..1094420) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /label="yitF gene" downshifts complement(1093334) /Source="Nicolas_upshifts" /id="D595" /incds=0 /nref=11 /ntot=42 /MaxReadThrough="1.81817" /MaxDrop="4.27426" /score="13.5713023" /energy="-14.5" /TU="NA" /idTUdmin="U883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1094429..1095697) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 14762009, 15109717, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388979.1" /db_xref="EnsemblGenomes-Gn:BSU10980" /db_xref="EnsemblGenomes-Tr:CAB12938" /db_xref="GOA:Q796Q1" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13112" /db_xref="UniProtKB/Swiss-Prot:Q796Q1" /translation="MESSKQNNGMTIVAIGSIPLILTLGNSMLIPILPKMKSELHLSQ FQVSLVITVFSLIAAFAIPIVGYLADRFSRKVIIIPCLILYGAGGLLAGFAAGFFDNA YPWVMAGRALQGIGAAGTGPIAMALTGDLFKGAQESKVLGLVEASNGMGKVLSPIIGS LIALLVWYGAFFAFPVFCIISIVLTWIFIKEKKKEKEPPPIGQYAKGLLSVFKHEGRW LFTAYLAGATCLFTLFGILFYLSDVLEKTYDTDGVKKGLILAIPLLVMCVTSYTTGSK IGQKQSLMKKLIVLGLAFMTVSYAALSFIENLVLFISVLVLSSIGSGLVLPCVNSFIT GAVGKERRGFVTSLYGSVRFLGVAIGPPIFGRLMQWSRPGMFLSIAGLTLVVGILVMM LIHVKQNNEETKEKEDPKMAGNRLQPAEER*" /label="yitG CDS" gene complement(1094429..1095697) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /label="yitG gene" promotor_-10 complement(1095723..1095734) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1095732) /Source="Nicolas_upshifts" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1095748..1095754) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1095809..1096657) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388980.1" /db_xref="EnsemblGenomes-Gn:BSU10990" /db_xref="EnsemblGenomes-Tr:CAB12939" /db_xref="GOA:O06743" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13113" /db_xref="UniProtKB/Swiss-Prot:O06743" /translation="MDVVDELIKLHEEHVSGLLRLCGQAGWPDYGEQELKLLVQQGRF FGYQNVSGDIISCIGLFLFGRLTSIGLVIVDKEYQRLGLGRRMVNACITQTDENTAIR LCATKEGLPLYEKAGFHTAGSVRKYSCHSFQPYTKKLDAELTSFREQDFHDLTAADLA AFGGDRSNLLQQLISASCECIIARNQDGQLIGYGLSVQTPANLKFGPIIAPSSDVAAQ IITRLAAGKQGPMRIDIPSEHTSLHDSLIEMGFHKDDEPPILFYQKKAPIQNGHLYAL ISQALG*" /label="yitH CDS" gene complement(1095809..1096657) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /label="yitH gene" downshifts complement(1095820) /Source="Nicolas_upshifts" /id="D596" /incds=0 /nref=34 /ntot=209 /MaxReadThrough="2.34135" /MaxDrop="3.51892" /score="14.8688564" /energy="-11.7" /TU="NA" /idTUdmin="U884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1096662..1097111) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388981.2" /db_xref="EnsemblGenomes-Gn:BSU11000" /db_xref="EnsemblGenomes-Tr:CAB12940" /db_xref="GOA:O06744" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13114" /db_xref="UniProtKB/Swiss-Prot:O06744" /translation="MLEVKTISVEDTYEIRHRILRPHQSIEQCKYKEDHAEGSFHLGV FYDGTLISIASFSPQSQPLLTEASAYRLRGMATLEGYRDQKAGSTLIKHAEHKLAESG VQAVWCNARHHVKGYYAKLGWKELGEPFDIPGIGNHIVMYKTLRTSR*" /label="yitI CDS" gene complement(1096662..1097111) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /label="yitI gene" promotor_-10 complement(1097132..1097151) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1097146) /Source="Nicolas_upshifts" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1097167..1097168) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1097201..1099039) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /EC_number="1.5.1.20" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 17264075, 20421295, 20951706, 26233166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional homocysteine S-methyltransferase using (R,S)AdoMet and methylenetetrahydrofolate reductase [NAD(P)H]" /protein_id="NP_388982.1" /db_xref="EnsemblGenomes-Gn:BSU11010" /db_xref="EnsemblGenomes-Tr:CAB12941" /db_xref="GOA:O06745" /db_xref="InterPro:IPR003171" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR029041" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG13115" /db_xref="UniProtKB/Swiss-Prot:O06745" /translation="MGLLEDLQRQVLIGDGAMGTLLYSYGIDRCFEELNISKPEEIQR IHKAYVEAGANIIQTNTYGANYIKLSRHGLEDDIKKMNQEAVKIARASAGDAYVLGTM GGIRTFNKNAYSLDEIKRSFREQLYLLLHEEPDGLLLETYYDLEEAREVLKIARKETD LPIMLNVSMHEQGVLQDGTPLSDALRSIADLGADIVGINCRLGPYHMIEALSEVPIFD DVFLSVYPNSSLPSLEEGRLVYETDDTYFQNSASEFRKQGARIIGGCCGTTPNHIRAM AEAVGGLAPITEKEVKTRAKEFISVHHERTEPGLDEIAAKKRSIIVELDPPKKLSFDK FLSAAAELKEAGIDALTLADNSLATPRISNVACGALVKQQLDMRSLVHITCRDRNIIG LQSHLMGLDTLGLNDVLAITGDPSKIGDFPGATSVYDLTSFDLIRLIKQFNEGLSLSG KPLGKKTNFSVAAAFNPNVRHLDKAVKRLEKKIDCGADYFVSQPVYSEQQLVDIHNET KHLKTPIYIGIMPLTSSRNAEFIHNEIPGIKLSDTIREKMAHAGEDKEKQKAEGLAIA RSLLDTACELFNGIYLITPFLRSDLTAELTSYIQQKDEQRQNIFLH*" /label="samT CDS" gene complement(1097201..1099039) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /label="samT gene" downshifts complement(1097228) /Source="Nicolas_upshifts" /id="D597" /incds=0 /nref=14 /ntot=91 /MaxReadThrough="3.04289" /MaxDrop="4.13744" /score="12.9586126" /energy="-16.2" /TU="U885" /idTUdmin="U885" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts complement(1099121) /Source="Nicolas_upshifts" /id="D598" /incds=0 /nref=47 /ntot=128 /MaxReadThrough="8.00128" /MaxDrop="5.61487" /score="22.3754155" /energy="-7.3" /TU="U885,U887" /idTUdmin="U887" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1099129..1099246) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswK RNA" gene complement(1099129..1099246) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /label="mswK gene" promotor_-10 complement(1099298..1099317) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" upshifts complement(1099312) /Source="Nicolas_upshifts" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1099332..1099339) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS complement(1099353..1099844) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12943362, 25329577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA or cyclic d-GMP binding protein" /protein_id="NP_388983.1" /db_xref="EnsemblGenomes-Gn:BSU11020" /db_xref="EnsemblGenomes-Tr:CAB12942" /db_xref="InterPro:IPR007551" /db_xref="InterPro:IPR035570" /db_xref="InterPro:IPR035571" /db_xref="InterPro:IPR036183" /db_xref="SubtiList:BG13116" /db_xref="UniProtKB/Swiss-Prot:O06746" /translation="MAKESSFDIVSKVELPEVQNAIQIALKEISTRYDFKGSKSDISL DKEELVLVSDDEFKLSQLKDVLVSKLIKRNVPTKNIDYGKVENASGGTVRQRAKLVQG IDKDNAKKINTIIKNSGLKVKSQVQDDQVRVTGKNKDDLQQIISAVRGADLPIDVQFI NFR*" /label="yitK CDS" gene complement(1099353..1099844) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /label="yitK gene" promotor_-35 1099862..1099865 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1099868..1099887) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" promotor_-10 1099880..1099899 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1099881 /Source="Nicolas_upshifts" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1099886) /Source="Nicolas_upshifts" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1099902..1099909) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS 1099943..1100839 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20399190; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA-binding protein" /protein_id="NP_388984.1" /db_xref="EnsemblGenomes-Gn:BSU11030" /db_xref="EnsemblGenomes-Tr:CAB12943" /db_xref="GOA:O06747" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014464" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13117" /db_xref="UniProtKB/Swiss-Prot:O06747" /translation="MLTKSAENKRNRKDDSMRPGQQLTLSIDHQTDFGYFLTDGEDTI LLHNSEMTEDIEDRDEVEVFIYVDQQERLAATMKIPIISADEYGWVEVVDKVEDMGVF VDVGLSKDALVATEHLPPYEDVWPQKGDKLYCMLKVTNRGRMFAKPAPEDIISELFTD ASEDLMNKELTGTVYRLIASGSFVITDDGIRCFIHPSERKEEPRLGSRVTGRVIQVKE DGSVNLSLLPRKQDAMSVDAECILTYMRMRNGAMPYSDKSQPDDIRERFNMSKAAFKR ALGHLMKNGKVYQENGWTYEKK*" /label="yitL CDS" gene 1099943..1100839 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /label="yitL gene" downshifts 1100826 /Source="Nicolas_upshifts" /id="D599" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="1.78082" /MaxDrop="6.73614" /score="40.361011" /energy="-21.5" /TU="NA" /idTUdmin="U886" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1100892..1101476) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388985.1" /db_xref="EnsemblGenomes-Gn:BSU11040" /db_xref="EnsemblGenomes-Tr:CAB12944" /db_xref="GOA:O06748" /db_xref="InterPro:IPR023888" /db_xref="SubtiList:BG13118" /db_xref="UniProtKB/Swiss-Prot:O06748" /translation="MKKAFLVFLSVVLVTTVFLVKQQESVAQAKQLEYSGEEIFKGFV FAQGEVGKQLPEVFNKAMTDKLNTKQAKAFANQVVADIKKEDADFFDNLKKAVYSKDA LKVDELLKKAGQIVEEKVEAAKEIAASKDDTSRVQAELVNTVDTANYFYYVSYVAAAG ALILIILAIDITPIAISDNVDREMAIRTLVDELN*" /label="yitM CDS" gene complement(1100892..1101476) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" /label="yitM gene" downshifts complement(1100902) /Source="Nicolas_upshifts" /id="D600" /incds=0 /nref=68 /ntot=158 /MaxReadThrough="1.3386" /MaxDrop="7.40935" /score="10.143892" /energy="-21.5" /TU="NA" /idTUdmin="U888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1101473..1102402) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11557812, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with HTTM domain" /protein_id="NP_388987.2" /db_xref="EnsemblGenomes-Gn:BSU11055" /db_xref="EnsemblGenomes-Tr:CAB12946" /db_xref="GOA:O06750" /db_xref="InterPro:IPR011020" /db_xref="InterPro:IPR023894" /db_xref="SubtiList:BG13120" /db_xref="UniProtKB/Swiss-Prot:O06750" /translation="MLENIKQTITRWDERNPWTNVYGLARSIIALSSLLTLLINHPSL IMKPASGISSYPACKMNLSLFCLGENNYMMLNLFRWVCIAILVLVVIGWRPRITGVLH WYVSYSLQSSLIVIDGGEQAAAVMTFLLLPITLTDPRKWHWSTRPIEGKRTLGKITAF ISYFVIRIQVAVLYFHSTVAKLSQQEWVDGTAVYYFAQEKTIGFNGFFQALTKPIVTS PFVVIPTWGTLLVQIVIFAALFAPKKHWRLILIIAVFMHEIFAVMLGLISFSIIMAGI LILYLTPIDSTIQFTYIRRLLWNKKHKKGEVSV*" /label="yitO CDS" gene complement(1101473..1102402) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" /label="yitO gene" upshifts complement(1101560) /Source="Nicolas_upshifts" /id="U888" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.232767232767233" /psig="0.63936063936064" /xcortree=2974 /SigmaFactorBS="agtcatgctgggcctcatcagtttttcgattatcatggccgg cattttgatattgtatctcaCtcctatcgattccacgattcaatttacatatattcgc a" /listShort="yitM" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1102387..1102923) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 6289325, 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388988.1" /db_xref="EnsemblGenomes-Gn:BSU11070" /db_xref="EnsemblGenomes-Tr:CAB12947" /db_xref="GOA:O06751" /db_xref="InterPro:IPR023902" /db_xref="SubtiList:BG13121" /db_xref="UniProtKB/Swiss-Prot:O06751" /translation="MQKSISFFVIFSILWGSLFLFSIIGSLGTTPIPLTKDSKFLMSS ILPQGWGFFSKNPRDTAIGLYEAENASAKVRWPNMRADNLFGLYRYGRSQGVEMGVIY SQVGKEQWTACKEKDLGACKSKAKTVQLKTPAPRPLLCGSYYLTKEDIVPWSYSKYTP SSYQVKSIVKVVISCSKT*" /label="yitP CDS" gene complement(1102387..1102923) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" /label="yitP gene" promotor_-10 complement(1102959..1102978) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1102973) /Source="Nicolas_upshifts" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1102993..1102996) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1103064..1103071 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1103086..1103105 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1103089 /Source="Nicolas_upshifts" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="upshifts" CDS 1103101..1103448 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097701.1" /db_xref="EnsemblGenomes-Gn:BSU11079" /db_xref="EnsemblGenomes-Tr:CAX52589" /db_xref="GOA:C0H3Y4" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Y4" /translation="MKTNQVNDRWIVQFRKGIFELAILSLLRSKPMYGYELTSSLKTT SALAISEGAIYPILKRMTEKGWIEFFWEDSLDGPKRKYYKMTQKGEEMLKERLEKYLE THQALLSLSGDLL*" /label="yizB CDS" gene 1103101..1103448 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" /label="yizB gene" CDS 1103445..1104032 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23504016" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388989.2" /db_xref="EnsemblGenomes-Gn:BSU11080" /db_xref="EnsemblGenomes-Tr:CAB12948" /db_xref="GOA:O06752" /db_xref="SubtiList:BG13122" /db_xref="UniProtKB/Swiss-Prot:O06752" /translation="MNGQLIIDRYMEELNAELANMPDVERENAIDELKGHITAFVQDR IKAGLSEEELQEAVESEFSHPKELAELMMGDGGETKRRRSLLGKSWISVLLIVTIIAL PLLPSDFRHLPLAVYLMVLAGYVWKRKKLVMFAGVRKNKMRSQKEIVKISRVGAVYLL FLAVVLLLSPFLNALVVLLLIAVSCAAFFLFLNIK*" /label="yitQ CDS" gene 1103445..1104032 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" /label="yitQ gene" CDS 1104052..1104345 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388990.1" /db_xref="EnsemblGenomes-Gn:BSU11090" /db_xref="EnsemblGenomes-Tr:CAB12949" /db_xref="GOA:O06753" /db_xref="InterPro:IPR017259" /db_xref="SubtiList:BG13123" /db_xref="UniProtKB/Swiss-Prot:O06753" /translation="MEISINYLLIVIALLFFVVAYFVGIKKQTWMLAGFNEARIRDKD RLARIAGYFFLNSGLFILLNSFISFQGQEQLIPPLILAYGAGVIIYVNKKLVE*" /label="yitR CDS" gene 1104052..1104345 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" /label="yitR gene" downshifts 1104325 /Source="Nicolas_upshifts" /id="D601" /incds=0 /nref=119 /ntot=240 /MaxReadThrough="1.96008" /MaxDrop="5.72545" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1104369 /Source="Nicolas_upshifts" /id="D602" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="0.34732" /MaxDrop="3.0285" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS 1104481..1106097 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1917867, 16672610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1917867, 16672610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral protease B" /protein_id="NP_388991.1" /db_xref="EnsemblGenomes-Gn:BSU11100" /db_xref="EnsemblGenomes-Tr:CAB12950" /db_xref="GOA:P39899" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10691" /db_xref="UniProtKB/Swiss-Prot:P39899" /translation="MRNLTKTSLLLAGLCTAAQMVFVTHASAEESIEYDHTYQTPSYI IEKSPQKPVQNTTQKESLFSYLDKHQTQFKLKGNANSHFRVSKTIKDPKTKQTFFKLT EVYKGIPIYGFEQAVAMKENKQVKSFFGKVHPQIKDVSVTPSISEKKAIHTARRELEA SIGKIEYLDGEPKGELYIYPHDGEYDLAYLVRLSTSEPEPGYWHYFIDAKNGKVIESF NAIHEAAGTGIGVSGDEKSFDVTEQNGRFYLADETRGKGINTFDAKNLNETLFTLLSQ LIGYTGKEIVSGTSVFNEPAAVDAHANAQAVYDYYSKTFGRDSFDQNGARITSTVHVG KQWNNAAWNGVQMVYGDGDGSKFKPLSGSLDIVAHEITHAVTQYSAGLLYQGEPGALN ESISDIMGAMADRDDWEIGEDVYTPGIAGDSLRSLEDPSKQGNPDHYSNRYTGTEDYG GVHINSSIHNKAAYLLAEGGVHHGVQVEGIGREASEQIYYRALTYYVTASTDFSMMKQ AAIEAANDLYGEGSKQSASVEKAYEAVGIL*" /label="nprB CDS" gene 1104481..1106097 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" /label="nprB gene" downshifts 1106085 /Source="Nicolas_upshifts" /id="D603" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="0.278770000000001" /MaxDrop="3.08544" /score="2.81939887" /energy="-8.6" /TU="NA" /idTUdmin="U890" /TUdmin=1760 /isTUend="FALSE" /label="downshifts" CDS complement(1106144..1106995) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit B" /protein_id="NP_388992.1" /db_xref="EnsemblGenomes-Gn:BSU11110" /db_xref="EnsemblGenomes-Tr:CAB12951" /db_xref="GOA:P70945" /db_xref="InterPro:IPR003797" /db_xref="SubtiList:BG12244" /db_xref="UniProtKB/Swiss-Prot:P70945" /translation="MTVHLIADSATDLPRSYFEEKGIGFIPLRVSLGDKEFEDAVTIH ADQIFEAMQNGETPKTSQASPQTIKNVFLQYAETGDPALYIAFSSGLSGTYQTAVMIA NEVKEEFPDFDLRVIDSKCASLGYGLAVRHAADLCINGNTIQEIETSVKNFCSQLEHI FTVDDLTYLARGGRISKTSAFVGGLLNIKPLLQMEDGKLVPLEKIRGQKKLFKRIIEL MKERGDDWSNQTVGISYAANKEKATDMKHLIEEAFKPKEIIMHPISSAIGSHAGPGTL AIFFLRK*" /label="fakBB CDS" gene complement(1106144..1106995) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" /label="fakBB gene" downshifts complement(1106161) /Source="Nicolas_upshifts" /id="D604" /incds=0 /nref=209 /ntot=263 /MaxReadThrough="0.727580000000001" /MaxDrop="6.86927" /score="-1.24586831" /energy="-7.7" /TU="NA" /idTUdmin="U892" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1106542..1106549 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1106564..1106583 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1106569..1107094 /Source="Nicolas_S_feature" /locus_tag="new_1188125_1188650" /HighExp="G180, Paraq, G135, G150, Oxctl, C30, H2O2, LBGstat, LBGexp, Lbexp" /AntisenseName="yitS" /AntisenseCor="-0.45830528686941202" /AntisenseRegPval="-14.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S395" upshifts 1106571 /Source="Nicolas_upshifts" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1107036..1107055) /Source="Nicolas_upshift_promotors" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1107059) /Source="Nicolas_upshifts" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1107073..1107078 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1107093..1107111 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1107096 /Source="Nicolas_upshifts" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="upshifts" CDS 1107133..1107975 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23419162, 23824080; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388993.1" /db_xref="EnsemblGenomes-Gn:BSU11120" /db_xref="EnsemblGenomes-Tr:CAB12952" /db_xref="GOA:P39803" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG10850" /db_xref="UniProtKB/Swiss-Prot:P39803" /translation="MVLDQTKKLLIVIIGALLNAAGLNLFLIPADVYASGFTGVAQLL SSVVDQYAPFYISTGTLLFLLNIPVGILGWLKVGKSFTVYSILSVALTTLFMGILPET SLSHDILLNAVFGGVISAVGIGLTLKYGASTGGLDIVAMVLAKWKDKPVGTYFFILNG IIILTAGLLQGWEKALYTLVTLYVTTRVIDAIHTRHMKLTAMIVTKKADEIKEAIYGK MVRGITTVPAKGAFTNEQKEMMIIVITRYELYDLEKIVKEVDPKAFTNIVQTTGIFGF FRKD*" /label="yitT CDS" gene 1107133..1107975 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /label="yitT gene" promotor_-35 1107628..1107636 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1107647..1107665 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1107647 /Source="Nicolas_upshifts" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="upshifts" S_feature 1107976..1108089 /Source="Nicolas_S_feature" /locus_tag="new_1189532_1189645" /HighExp="Etha, S8, Sw, M9-stat, S7, BC, Gly, S6, Salt, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigB, SigA" /TUshortPSig="0.968, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S396" CDS 1108090..1108449 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8226659, 24555072" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226659, 24555072; Product type f: factor" /codon_start=1 /transl_table=11 /product="intracellular proteinase inhibitor BsuPI" /protein_id="NP_388994.1" /db_xref="EnsemblGenomes-Gn:BSU11130" /db_xref="EnsemblGenomes-Tr:CAB12953" /db_xref="GOA:P39804" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR020481" /db_xref="PDB:3ISY" /db_xref="SubtiList:BG10852" /db_xref="UniProtKB/Swiss-Prot:P39804" /translation="MENQEVVLSIDAIQEPEQIKFNMSLKNQSERAIEFQFSTGQKFE LVVYDSEHKERYRYSKEKMFTQAFQNLTLESGETYDFSDVWKEVPEPGTYEVKVTFKG RAENLKQVQAVQQFEVK*" /label="ipi CDS" gene 1108090..1108449 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /label="ipi gene" downshifts 1108438 /Source="Nicolas_upshifts" /id="D605" /incds=0 /nref=34 /ntot=224 /MaxReadThrough="1.36729" /MaxDrop="5.6855" /score="43.7575824" /energy="-15.6" /TU="NA" /idTUdmin="U893" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1108480..1108677) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; genus orphan" /protein_id="YP_003097702.1" /db_xref="EnsemblGenomes-Gn:BSU11139" /db_xref="EnsemblGenomes-Tr:CAX52590" /db_xref="InterPro:IPR024217" /db_xref="UniProtKB/Swiss-Prot:C0H3Y5" /translation="MRNELFQQAKSFVQQAVMVTNGFEEGDQEQAILRAKNAVSSAYA NSTDAERQQLHQFQNQLDKLQ*" /label="yizC CDS" gene complement(1108480..1108677) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /label="yizC gene" downshifts complement(1108493) /Source="Nicolas_upshifts" /id="D606" /incds=0 /nref=150 /ntot=257 /MaxReadThrough="1.42333" /MaxDrop="8.284" /score="2.35557074" /energy="-17.3" /TU="NA" /idTUdmin="U895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1108678..1108874) /Source="Nicolas_S_feature" /locus_tag="new_1190234_1190430_c" /HighExp="S8, S6, S5, S7, nit, ferm, BT, G/S, Pyr, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99834599999999996" /TUshortSig="SigGF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S397" upshifts complement(1108874) /Source="Nicolas_upshifts" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1108876..1108887) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1108902..1108908) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1108934..1109746) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25012491, 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous)" /protein_id="NP_388995.1" /db_xref="EnsemblGenomes-Gn:BSU11140" /db_xref="EnsemblGenomes-Tr:CAB12954" /db_xref="GOA:P70947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12245" /db_xref="UniProtKB/Swiss-Prot:P70947" /translation="METKPYLIALDLDGTLLKDDKTISENTLHTIQRLKDDGHYVCIS TGRPYRSSSMYYQQMELTTPIVNFNGAFVHHPQDDSWGRYHTSLPLDVVKQLVDISES YNVHNVLAEVIDDVYFHYHDEHLIDAFNMNTTNVTVGDLRENLGEDVTSVLIHAKEED VPAIRSYLSDVHAEVIDHRRWAAPWHVIEIIKSGMNKAVGLQKISDYYGVPRERIIAF GDEDNDLEMLEFAGCGVAMGNGIDAVKQIANRTTATNEEDGVARFLKEYFSL*" /label="ribZC CDS" gene complement(1108934..1109746) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /label="ribZC gene" promotor_-10 complement(1109784..1109803) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1109804..1109811 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1109804) /Source="Nicolas_upshifts" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1109817..1109824) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1109823..1109842 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1109825 /Source="Nicolas_upshifts" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1109867..1110634 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28293230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxylesterase" /protein_id="NP_388996.1" /db_xref="EnsemblGenomes-Gn:BSU11150" /db_xref="EnsemblGenomes-Tr:CAB12955" /db_xref="GOA:P70948" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12246" /db_xref="UniProtKB/Swiss-Prot:P70948" /translation="MIQIENQTVSGIPFLHIVKEENRHRAVPLVIFIHGFTSAKEHNL HIAYLLAEKGFRAVLPEALHHGERGEEMAVEELAGHFWDIVLNEIEEIGVLKNHFEKE GLIDGGRIGLAGTSMGGITTLGALTAYDWIKAGVSLMGSPNYVELFQQQIDHIQSQGI EIDVPEEKVQQLMKRLELRDLSLQPEKLQQRPLLFWHGAKDKVVPYAPTRKFYDTIKS HYSEQPERLQFIGDENADHKVPRAAVLKTIEWFETYL*" /label="yitV CDS" gene 1109867..1110634 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /label="yitV gene" promotor_-35 1110643..1110649 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1110663 /Source="Nicolas_upshifts" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1110664..1110683 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1110698..1111006 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9209063; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein involved in Fe-S cluster assembly, PaaD-like" /protein_id="NP_388997.1" /db_xref="EnsemblGenomes-Gn:BSU11160" /db_xref="EnsemblGenomes-Tr:CAB12956" /db_xref="InterPro:IPR002744" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG12247" /db_xref="UniProtKB/Swiss-Prot:P70949" /translation="MEEALKENIMGALEQVVDPELGVDIVNLGLVYDVDMDEDGLTHI TMTLTSMGCPLAPIIVDEVKKALADLPEVKDTEVHIVWNPPWTRDKMSRYAKIALGIQ *" /label="yitW CDS" gene 1110698..1111006 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /label="yitW gene" downshifts 1110991 /Source="Nicolas_upshifts" /id="D607" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="5.65659" /MaxDrop="4.5598" /score="14.9971829" /energy="-14.7" /TU="U897,U898" /idTUdmin="U897" /TUdmin="-2244" /isTUend="FALSE" /label="downshifts" S_feature 1111036..1111301 /Source="Nicolas_S_feature" /locus_tag="new_1192592_1192857" /HighExp="Etha, dia15, dia5, H2O2, LoTm, Salt, S6, Diami, S8, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S398" CDS 1111302..1112732 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16956367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN/FAD-binding oxidoreductase" /protein_id="NP_388999.3" /db_xref="EnsemblGenomes-Gn:BSU11170" /db_xref="EnsemblGenomes-Tr:CAB12958" /db_xref="GOA:Q796P5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12249" /db_xref="UniProtKB/Swiss-Prot:Q796P5" /translation="MKKKLLAFALCTGAYAALFAYSVNSEQKTATSEMTDVSRLMPVK IKQTVKGQEEEMLIDTVKEANRKNIKISIAGAQHSMGGHTYYEDGIVLDMTGYNKILS LDQEKKTIRVQSGATWNDIQKYVNPYGLAVKVMQSQNIFTIGGSLSANAHGRDIRYGS LIDTVKSFRLLKADGMIITVTPKDDLFTAVIGGYGLFGVILDVTLELTDDELYVMKTE KMNYSTYSDYFSKHVKGNPDVRMHLARISTAKKGFLKDMYVTNYVLANHQDQLSSYSE LKEDEYTGATKFALGLSRRYEWGRNWLWDTQQSYFLSQNGTEISRNNVMRSESKFLEY ENNDNTDVLQEYFVPVKEYGSYIDDLRQTLSDEDLNLLNITIRYVQKNEKADLSYAKD DMFSLVLLINEGFSKEDQADTARIIRRMTDVAIKHGGSYYLPYMTYQTKAQMRQAYPK SEAFFQKKRTYDPDERFMNYFYQRYK*" /label="yitY CDS" gene 1111302..1112732 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /label="yitY gene" CDS 1112777..1113271 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transport protein" /protein_id="NP_389000.1" /db_xref="EnsemblGenomes-Gn:BSU11180" /db_xref="EnsemblGenomes-Tr:CAB12959" /db_xref="GOA:P70952" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12250" /db_xref="UniProtKB/Swiss-Prot:P70952" /translation="MFFASSLIFPFYILFVKNIGSSYTQFGFSYGLFGLSGALIYPLL GRLSERFDSRYFLLLNSWGMAVLLLYVPHIGSVVQVYIVQVLLGLFGAMQKHGEKVLI ANFTDSGERGKKIGNYHFWTAVFSAAAIMLGGFLADFFTVQMIFYASSILYFLSGLMM MKTG*" /label="yitZ CDS" gene 1112777..1113271 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /label="yitZ gene" downshifts 1113235 /Source="Nicolas_upshifts" /id="D608" /incds=0 /nref=49 /ntot=208 /MaxReadThrough="1.74762" /MaxDrop="4.22077" /score="34.1294744" /energy="-13.2" /TU="NA" /idTUdmin="U897" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1113409..1113416 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1113415 /Source="Nicolas_upshifts" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1113430..1113449 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1113478..1114515 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /EC_number="1.2.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate gamma-semialdehyde dehydrogenase" /protein_id="NP_389001.2" /db_xref="EnsemblGenomes-Gn:BSU11190" /db_xref="EnsemblGenomes-Tr:CAB12960" /db_xref="GOA:P23715" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR000706" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR023013" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10191" /db_xref="UniProtKB/Swiss-Prot:P23715" /translation="MKIGIVGATGYGGTELVRILSHHPHAEECILYSSSGEGNVYSEG YPHLTGLADQQLKPIDMNTIKHEIDIMFLAAPPGVSSELTPKLADAGITVIDLSGDLR IKEPAEYEKWYKRTAAPKAVIQEAVYGLAELNQLQIQQAKLIANPGCFPTAVLLGLAP LAQKKLLDESFVIVDAKTGVSGAGRKASMGTHFSELNDNFKIYKVNEHQHTPEIEQAL NEWQPGLGPITFSAHLVPMTRGIMATMYTRLTCDLTADDLHDLYSEFYQDSYFVRVRP KGQYPQTKEVYGSNFCDIAVTLDERTNRVTIVSVIDNLMKGAAGQAVQNFNLMNGWNE ETGLTITPIYP*" /label="argC CDS" gene 1113478..1114515 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /label="argC gene" CDS 1114535..1115755 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /EC_number="2.3.1.1" /EC_number="2.3.1.35" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8025667, 10931207, 16409639, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8025667, 10931207, 16409639, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine acetyltransferase; amino-acid acetyltransferase" /protein_id="NP_389002.2" /db_xref="EnsemblGenomes-Gn:BSU11200" /db_xref="EnsemblGenomes-Tr:CAB12961" /db_xref="GOA:P36843" /db_xref="InterPro:IPR002813" /db_xref="InterPro:IPR016117" /db_xref="SubtiList:BG10192" /db_xref="UniProtKB/Swiss-Prot:P36843" /translation="MIQLSEDQIVKVTGDVSSPKGFQAKGVHCGLRYSKKDLGVIISE TPAVSAAVYTQSHFQAAPIKVTQDSLKHGPTLKAVIVNSAIANACTGEQGLKDAYTMR ESFASQLGIEPELVAVSSTGVIGEHLDMEKIHAGIELLKETPAGSGDFEEAILTTDTV IKQTCYELAIGGKTVTIGGAAKGSGMIHPNMATMLGFVTTDAAIEEKALQKALREITD VSFNQITVDGETSTNDMVLVMANGCAENECLTEDHPDWPVFKKALLLTCEDLAKEIAR DGEGATKLIEAQVQGAKNNLDANVIAKKIVGSNLVKTAVYGTDANWGRIIGAIGHSAA QVTAEEVEVYLGGQCLFKNNEPQPFSESIAKEYLEGDEITIVIKMAEGDGNGRAWGCD LTYDYIKINASYRT*" /label="argJ CDS" gene 1114535..1115755 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /label="argJ gene" CDS 1115770..1116546 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /EC_number="2.7.2.8" /experiment="publication(s) with functional evidences, PMID:3005232, 8473852" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3005232, 8473852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate 5-phosphotransferase (acetylglutamate kinase)" /protein_id="NP_389003.1" /db_xref="EnsemblGenomes-Gn:BSU11210" /db_xref="EnsemblGenomes-Tr:CAB12962" /db_xref="GOA:P68729" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR004662" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10193" /db_xref="UniProtKB/Swiss-Prot:P68729" /translation="MKKTIVFKCGGSVIRELSEEFYQNLKELRASGWKLAIVHGGGPE ITNMLKRLNIKTEFSGGQRKTTKPVLEVAEMVLSGSVNKFFVAELAKHGLRAAGISGK DGGLLEADYLDPETYGEVGEIKKVDASMVNALMENGIIPVIAPLSMTSDCKTLNVNAD LAASAVAGALEADKLMFVTDVDGIMKEKQRLDVLTPKEIQMLIKQEVITGGMIPKVNS ALSALSDQVSEVMIVNGKGSFFAEQTFQGTKIVKAKEAVS*" /label="argB CDS" gene 1115770..1116546 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /label="argB gene" CDS 1116543..1117700 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /EC_number="2.6.1.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17012789; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylornithine aminotransferase" /protein_id="NP_389004.2" /db_xref="EnsemblGenomes-Gn:BSU11220" /db_xref="EnsemblGenomes-Tr:CAB12963" /db_xref="GOA:P36839" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10194" /db_xref="UniProtKB/Swiss-Prot:P36839" /translation="MSSLFQTYGRWDIDIKKAKGTYVEDQNGKTYLDFIQGIAVSNLG HCHEAVTEAVKKQLDSVWHVSNLFQNSLQEQAAQKLAAHSAGDLVFFCNSGAEANEGA IKLARKATGKTKIITFLQSFHGRTYAGMAATGQDKIKTGFGPMLGGFHYLPYNDPSAF KALGEEGDIAAVMLETVQGEGGVNPASAEFLSAVQSFCKEKQALLIIDEIQTGIGRTG KGFAYEHFGLSPDIITVAKGLGNGFPVGAVIGKKQLGEAFTPGSHGTTFGGNMLAMAA VNATLQIVFQPDFLQEAADKGAFLKEQLEAELKSPFVKQIRGKGLMLGIECDGPVADI IAELQTLGLLVLPAGPNVIRLLPPLTVTKDEIAEAVSKLKQAIAHHSAVNQ*" /label="argD CDS" gene 1116543..1117700 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /label="argD gene" CDS 1117771..1118826 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 230177, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 230177, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(small subunit)" /protein_id="NP_389005.2" /db_xref="EnsemblGenomes-Gn:BSU11230" /db_xref="EnsemblGenomes-Tr:CAB12964" /db_xref="GOA:P36838" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10195" /db_xref="UniProtKB/Swiss-Prot:P36838" /modified_by="User" /translation="MEGYLVLEDGTSFSGELDGHENCTGEAVFFTGMTGYQEVLTDPS YKGQIIVFTYPLIGNYGINEKDFESKKPQVKAAVVYEACDHFSHYEAVYSLKEYLQKW NIPLLTHVDTRAVVKKIRANGTMGATVTASKEGAEIALQPENVAEQASAQEISTFGDG NKHIALIDFGYKKSIASSLVKRGCKVTVVPYQQMEAVYNIKPDGLSNGPGDPKAIQPY LGKIKSIISRFPTLGICLGHQLIALAFGGNTFKLPFGHRGANHPVIDRKTKRVFMTSQ NHSYVVDEQSINEEELTIRFHHVNDTSVEGLAHKKLPVMSVQFHPEAHPGPAESEWIF DDYLKNVIPARREIAHA*" /label="Delta6_BSU_11230_SNPvariant" gene 1117771..1118826 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /modified_by="User" /label="Delta6_BSU_11230_SNPvariant" Polymorphism join(1118381,1118382) /Source="geneious" /ID="SNP_BsDelta6_1199938_1199943" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=6 /Amino_Acid_Change="GIV -> G" /CDS_Position=612 /Change="-AATTGT" /Codon_Change="GGA,ATT,GTG -> GGG" /Coverage="183 -> 185" /locus_tag="BSU_11230" /Protein_Effect="Deletion" /Reference_Frequency /Reference_Nucleotides="AATTGT" /Variant_Nucleotides /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="Delta6_BSU_11230_SNPvariant" / /modified_by="User" /label="Polymorphism_Delta6" misc_feature complement(1118660..1118679) /Source="Nicolas_upshift_promotors" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1118670) /Source="Nicolas_upshifts" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1118819..1121911 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(large subunit)" /protein_id="NP_389006.3" /db_xref="EnsemblGenomes-Gn:BSU11240" /db_xref="EnsemblGenomes-Tr:CAB12965" /db_xref="GOA:P18185" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR036897" /db_xref="SubtiList:BG10196" /db_xref="UniProtKB/Swiss-Prot:P18185" /translation="MPKDTSISSILVIGSGPIIIGQAAEFDYSGTQGCIALKEEGYRV ILVNSNPATIMTDEAFADEIYFEPLTAESLTAIIKKERPDGLLANLGGQTALNLAVEL EETGVLKEHGVKLLGTSVETIQKGEDREKFRSLMNELKQPVPESEIVDNEADALHFAE SIGFPVIIRPAYTLGGKGGGIAPDKEAFTAMIKQALLASPINQCLVEKSIAGFKEIEY EVMRDSNNTCITVCNMENIDPVGVHTGDSIVVAPSQTLTDEDYQMLRTASLTIISALD VVGGCNIQFALDPFSKQYYVIEVNPRVSRSSALASKATGYPIAKMAAKLAVGYTLDEL KNPLTGSTYASFEPALDYVIVKFPRWPFDKFKNADRKLGTKMKATGEVMAIERNLEAA IQKAAASLELKNIGTHLPELSGLSIDTLWDLAITPDDRRFFVVMELLSRSVSIDDIHE KTKIDPFFLHTFDNIIKLENRLMEAGSDLSFELLKKAKEKGFSDATIASLISKTEEEV RALRKEMGITPSFKIVDTCAAEFDAKTNYFYSTYFGETDGDISRKEKKRALIIGSGPI RIGQGVEFDYSAVHGVLTLQELGFETIMINNNPETVSTDYEIADRLYFEPMTTEHIVN VAEQENIDFAIVQFGGQTAINAAEALEKAGITLLGTSFQTLDVLEDRDQFYQLLDELG LKHAKGEIAYTKEEAASKASEIGYPVLIRPSYVIGGMGMIIVDSQAQLSQLLNDEDSM PYPILIDQYVSGKEVEIDLISDGEEVFIPTYTEHIERAGVHSGDSFAILPGPSITSGL QQGMKDAAQKIARKLSFKGIMNIQFVIDNGNILVLEVNPRASRTVPVVSKVMGVPMIP LATRLLAGASLKDLNPAVQNHHGVAVKFPVFSSHAIQDVDVKLGPEMKSTGEGMCVAY DSNSALKKIYTRVWSQKGSIYLQNVPEDVKELAENAGFTIHEGTFASWMEQEGNSLHI NLSGSEEARKERLEAMTHGIPVFTEEETVRAFLQSGSGHPQPVSLKDLYKKEVASCTQ *" /label="carB CDS" gene 1118819..1121911 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /label="carB gene" CDS 1121899..1122858 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /EC_number="2.1.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3099126, 6409881, 8025667, 9346304, 16585758, 26443366" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3099126, 6409881, 8025667, 9346304, 16585758, 26443366; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ornithine carbamoyltransferase" /protein_id="NP_389007.1" /db_xref="EnsemblGenomes-Gn:BSU11250" /db_xref="EnsemblGenomes-Tr:CAB12966" /db_xref="GOA:P18186" /db_xref="InterPro:IPR002292" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR024904" /db_xref="InterPro:IPR036901" /db_xref="SubtiList:BG10197" /db_xref="UniProtKB/Swiss-Prot:P18186" /translation="MHTVTQTSLYGKDLLTLKDLSEEDINALLAEAGELKQNKIQPIF HGKTLAMIFEKSSTRTRVSFEAGMAQLGGSALFLSQKDLQLGRGETVADTAKVLSGYV DAIMIRTFEHEKVEELAKEADIPVINGLTDKYHPCQALADLLTIKEIKGKLKGVKVAY IGDGNNVAHSLMIGCAKMGCDISIASPKGYEVLDEAAEAAKTYALQSGSSVTLTDDPI EAVKDADVIYSDVFTSMGQEAEEQERLAVFAPYQVNAALVSHAKPDYTFLHCLPAHRE EEVTAEIIDGPNSAVFQQAENRLHVQKALLKAILYKGESSKNC*" /label="argF CDS" gene 1121899..1122858 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /label="argF gene" downshifts 1122821 /Source="Nicolas_upshifts" /id="D609" /incds=0 /nref=141 /ntot=268 /MaxReadThrough="4.29547" /MaxDrop="7.69347" /score="22.2660758" /energy="-11.1" /TU="U899" /idTUdmin="U899" /TUdmin="-305" /isTUend="FALSE" /label="downshifts" S_feature complement(1122861..1123135) /Source="Nicolas_S_feature" /locus_tag="new_1204423_1204697_c" /HighExp="G135, G180, Cold, LBGexp, G150, B60, LoTm, Paraq, Oxctl, H2O2" /AntisenseName="yjzC" /AntisenseCor="-0.37122740772860502" /AntisenseRegPval="-9.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S399" promotor_-35 1122886..1122892 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1122894) /Source="Nicolas_upshifts" /id="D610" /incds=0 /nref=33 /ntot=166 /MaxReadThrough="1.19008" /MaxDrop="5.22155" /score="16.2777759" /energy="-11.2" /TU="NA" /idTUdmin="U902" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 1122907..1122918 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1122928 /Source="Nicolas_upshifts" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="upshifts" CDS 1122944..1123123 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25859258" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389008.1" /db_xref="EnsemblGenomes-Gn:BSU11260" /db_xref="EnsemblGenomes-Tr:CAB12967" /db_xref="InterPro:IPR025549" /db_xref="SubtiList:BG13223" /db_xref="UniProtKB/Swiss-Prot:O34585" /translation="MGQQHQFRPGQKAPNNGVYVEIGETGSMVKNPQKVHLSAGEMFP ETSNHNRLWTYKRKP*" /label="yjzC CDS" gene 1122944..1123123 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /label="yjzC gene" downshifts 1123133 /Source="Nicolas_upshifts" /id="D611" /incds=0 /nref=19 /ntot=53 /MaxReadThrough="0.25116" /MaxDrop="5.67653" /score="4.8153862" /energy="-10.9" /TU="NA" /idTUdmin="U899" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1123169..1123354) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19775244" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19775244; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore targeted protein" /protein_id="NP_389009.1" /db_xref="EnsemblGenomes-Gn:BSU11270" /db_xref="EnsemblGenomes-Tr:CAB12968" /db_xref="GOA:O34713" /db_xref="InterPro:IPR021324" /db_xref="SubtiList:BG13224" /db_xref="UniProtKB/Swiss-Prot:O34713" /translation="MRYIIAFIWTFLLSHMACYLVASMNSVTYNFKTSSVIAVVLYVL IMVLAEIMPMNKNASQH*" /label="yjzD CDS" gene complement(1123169..1123354) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /label="yjzD gene" downshifts complement(1123180) /Source="Nicolas_upshifts" /id="D612" /incds=0 /nref=215 /ntot=261 /MaxReadThrough="3.91391" /MaxDrop="6.26103" /score="9.62656276" /energy="-10.9" /TU="U902" /idTUdmin="U902" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1123383..1123402) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1123400) /Source="Nicolas_upshifts" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1123413..1123420) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1123455..1123461 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1123473..1123492 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1123478 /Source="Nicolas_upshifts" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1123535..1123544 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1123544 /Source="Nicolas_upshifts" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1123557..1123576 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1123603..1124337 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 18582593" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389010.1" /db_xref="EnsemblGenomes-Gn:BSU11280" /db_xref="EnsemblGenomes-Tr:CAB12969" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13124" /db_xref="UniProtKB/Swiss-Prot:O35001" /translation="MGITERYFQLGTEHNVIHLPYRPNGFGIFILGDRTHFVGHDSSF WQQHYGRNQLLSMLMNEGYTLFNSNLFGRHWGAEKAVTYAKQLIHSVLKQEILNPKIH ILAEGMGALVADELLRFSPDHIRSAAMLNPCLDLQAHYESEKENKFFYKQFLKEVSKS YGISEKEAEAIRYKTIQSYPSGVPVHIWQRMTGAPYPYSVHAEVFKEKQQKQGSPVDM TFHLFEHPSRIYASICKFFHSHEKEL*" /label="yjaU CDS" gene 1123603..1124337 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /label="yjaU gene" S_feature complement(1124096..1124698) /Source="Nicolas_S_feature" /locus_tag="new_1205658_1206260_c" /HighExp="S8, S6, S7, C30, BT, S4, S5, Pyr, S3, C90" /AntisenseName="yjaV" /AntisenseCor="0.66207512383157796" /AntisenseRegPval="-34.6" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.468" /TUlongSig="NA" /TUlongPSig="NA" /label="S400" promotor_-35 1124318..1124323 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1124336 /Source="Nicolas_upshifts" /id="D613" /incds=0 /nref=6 /ntot=47 /MaxReadThrough="5.56163" /MaxDrop="4.5381" /score="1.90624641" /energy="-10" /TU="U904,U905" /idTUdmin="U904" /TUdmin="-945" /isTUend="FALSE" /label="downshifts" upshifts 1124336 /Source="Nicolas_upshifts" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1124339..1124357 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1124419..1124976 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P) binding enzyme" /protein_id="NP_389011.2" /db_xref="EnsemblGenomes-Gn:BSU11290" /db_xref="EnsemblGenomes-Tr:CAB12970" /db_xref="SubtiList:BG13125" /db_xref="UniProtKB/Swiss-Prot:O34959" /translation="MESTLIVGADEFFGLSLCERMMDEGIHVDVVLAETEDKMRQMYL EERLMWLGRNELFRQLEHIGDQNYDTICIQFGSFLPLDQYDSPYILVYEEDRKEWDKR EKTGSEKTVILPKMYGPWKEETEEDGYYTNDVADELLRFLLEPSRHSKDQLFELQVTE KTSKEEAKTKIIEWKRQFSSIFDKY*" /label="yjaV CDS" gene 1124419..1124976 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /label="yjaV gene" promotor_-10 complement(1124678..1124697) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1124698) /Source="Nicolas_upshifts" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1124712..1124716) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1124983..1124990 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1125005..1125024 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1125017 /Source="Nicolas_upshifts" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1125067..1126020 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1203607, 21622736, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1203607, 21622736, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="positive regulator of comK" /protein_id="NP_389012.2" /db_xref="EnsemblGenomes-Gn:BSU11300" /db_xref="EnsemblGenomes-Tr:CAB12971" /db_xref="GOA:O32436" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13126" /db_xref="UniProtKB/Swiss-Prot:O32436" /translation="MITRLVMIFSVLLLLSGCGQTPFKGKIEKVGMLFPDTINDLVWG TKGYKGLLNIQSKYNVDVYYKEGVKTEEDIINAIEDFHKRGVNLLYGHGSEYAEVFNL VGEDYPDMEFVISNAKAKADNVTSVHFSGEAMGFFGGMTAAHMSKTNQVGVIASFTWQ PEVDGFIKGAKYENPDIEVNTKYTDHWDDDTTAVKLYQKMKNEGADVVYPAGDGYNVP VIQQIKKDGLYAIGYVTDQSDLGENTVLTSTVQNVDKAYEIIAEQFNKGTLEGGDHYY DLNTGVVEMGTFSPLVDQDFQQRIAKLIKTYNKTGELPKNE*" /label="med CDS" gene 1125067..1126020 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /label="med gene" promotor_-35 1125684..1125688 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1125704..1125723 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1125717 /Source="Nicolas_upshifts" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1126035..1126226 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10940045; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative late competence gene" /protein_id="NP_389013.1" /db_xref="EnsemblGenomes-Gn:BSU11310" /db_xref="EnsemblGenomes-Tr:CAB12972" /db_xref="GOA:O32437" /db_xref="InterPro:IPR024558" /db_xref="SubtiList:BG13221" /db_xref="UniProtKB/Swiss-Prot:O32437" /translation="MQHEKSLEFLQIAMKYLPEAKEQLEKSGIELSMEAIQPFMNLFT TVMAEAYELGKSDAKSETE*" /label="comZ CDS" gene 1126035..1126226 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /label="comZ gene" downshifts 1126205 /Source="Nicolas_upshifts" /id="D614" /incds=0 /nref=32 /ntot=192 /MaxReadThrough="4.56858" /MaxDrop="3.45953" /score="-7.49795364" /energy="-10.4" /TU="U907,U908" /idTUdmin="U905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1126250..1126590 /Source="Nicolas_S_feature" /locus_tag="new_1207812_1208152" /HighExp="H2O2, C30, G135, Paraq, G180, G150, Oxctl, Cold, dia15, LPh" /AntisenseName="yjzB" /AntisenseCor="-0.34349942363230701" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S401" CDS complement(1126256..1126495) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /experiment="publication(s) with functional evidences, PMID:16391061, 22171814, 27227299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16391061, 22171814, 27227299; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389014.1" /db_xref="EnsemblGenomes-Gn:BSU11320" /db_xref="EnsemblGenomes-Tr:CAB12973" /db_xref="SubtiList:BG13222" /db_xref="UniProtKB/Swiss-Prot:O34891" /translation="MQLDVFSRMMFGDAAKPTEEKEEEQQEEVSQVSQTNDEETINYM HIMDQIGSIMNSLDQIKPALKELAPMLSAIKKKIM*" /label="yjzB CDS" gene complement(1126256..1126495) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /label="yjzB gene" downshifts complement(1126272) /Source="Nicolas_upshifts" /id="D615" /incds=0 /nref=21 /ntot=48 /MaxReadThrough="1.43519" /MaxDrop="5.47891" /score="-7.75082002" /energy="-10.4" /TU="NA" /idTUdmin="U909" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1126508..1126527) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1126529) /Source="Nicolas_upshifts" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1126541..1126550) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1126556..1126563 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1126578..1126597 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1126592 /Source="Nicolas_upshifts" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="upshifts" CDS 1126660..1127598 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 11959561, 21542858, 25196128" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 11959561, 21542858, 25196128; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 1" /protein_id="NP_389015.1" /db_xref="EnsemblGenomes-Gn:BSU11330" /db_xref="EnsemblGenomes-Tr:CAB12974" /db_xref="GOA:O34746" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13127" /db_xref="UniProtKB/Swiss-Prot:O34746" /translation="MKAGILGVGRYIPEKVLTNHDLEKMVETSDEWIRTRTGIEERRI AADDVFSSHMAVAAAKNALEQAEVAAEDLDMILVATVTPDQSFPTVSCMIQEQLGAKK ACAMDISAACAGFMYGVVTGKQFIESGTYKHVLVVGVEKLSSITDWEDRNTAVLFGDG AGAAVVGPVSDDRGILSFELGADGTGGQHLYLNEKRHTIMNGREVFKFAVRQMGESCV NVIEKAGLSKEDVDFLIPHQANIRIMEAARERLELPVEKMSKTVHKYGNTSAASIPIS LVEELEAGKIKDGDVVVMVGFGGGLTWGAIAIRWGR*" /label="fabHA CDS" gene 1126660..1127598 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /label="fabHA gene" promotor_-35 1126737..1126746 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1126755 /Source="Nicolas_upshifts" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1126758..1126773 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1127621..1128862 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /EC_number="2.3.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11325930, 12682299, 16436705, 18384517, 21542858, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325930, 12682299, 16436705, 18384517, 21542858, 28196402; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase II (involved in pimelate synthesis)" /protein_id="NP_389016.1" /db_xref="EnsemblGenomes-Gn:BSU11340" /db_xref="EnsemblGenomes-Tr:CAB12975" /db_xref="GOA:O34340" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR017568" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020841" /db_xref="PDB:4LS5" /db_xref="PDB:4LS6" /db_xref="PDB:4LS7" /db_xref="PDB:4LS8" /db_xref="SubtiList:BG13128" /db_xref="UniProtKB/Swiss-Prot:O34340" /translation="MTKKRVVVTGLGALSPLGNDVDTSWNNAINGVSGIGPITRVDAE EYPAKVAAELKDFNVEDYMDKKEARKMDRFTQYAVVAAKMAVEDADLNITDEIAPRVG VWVGSGIGGLETLESQFEIFLTKGPRRVSPFFVPMMIPDMATGQISIALGAKGVNSCT VTACATGTNSIGDAFKVIQRGDADVMVTGGTEAPLTRMSFAGFSANKALSTNPDPKTA SRPFDKNRDGFVMGEGAGIIVLEELEHALARGAKIYGEIVGYGSTGDAYHITAPAQDG EGGARAMQEAIKDAGIAPEEIDYINAHGTSTYYNDKYETMAIKTVFGEHAHKLAVSST KSMTGHLLGAAGGIEAIFSILAIKEGVIPPTINIQTPDEECDLDYVPDEARRQELNYV LSNSLGFGGHNATLIFKKYQS*" /label="fabF CDS" gene 1127621..1128862 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /label="fabF gene" promotor_-10 complement(1127835..1127853) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1127843) /Source="Nicolas_upshifts" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1127869..1127874) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1128713 /Source="Nicolas_upshifts" /id="D616" /incds=1 /nref=1 /ntot=89 /MaxReadThrough="7.03006" /MaxDrop="2.1101" /score="54.6350161" /energy="-18.5" /TU="U910,U911" /idTUdmin="U911" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 1128846 /Source="Nicolas_upshifts" /id="D617" /incds=0 /nref=246 /ntot=274 /MaxReadThrough="0.58964" /MaxDrop="7.80446" /score="54.6350161" /energy="-18.5" /TU="NA" /idTUdmin="U911" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 1128887..1128896 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-35" promotor_-10 1128909..1128928 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-10" upshifts 1128911 /Source="Nicolas_upshifts" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="upshifts" promotor_-35 1128923..1128931 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1128938..1129723 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389017.1" /db_xref="EnsemblGenomes-Gn:BSU11350" /db_xref="EnsemblGenomes-Tr:CAB12992" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13129" /db_xref="UniProtKB/Swiss-Prot:O31596" /translation="MSVEQTYSWLRKAGSIDDLAHYIIPLFSGAEKKNWKGILGHLQH HGMFKNIKEGIQTVSKLKEKGFYGHIQKEEQYLKNKWQGPDVPIVTLPVDERNRRIRL EFGSKSGLAFQDKMFLFLSSDLDFGSVSALMTHEYHHVCRLGHLTKEEKDVTLLDTII MEGLAEYAVYERFGRSQTAEWTTWYTPEQLQALYEKKIAPHRDIKRDNRLFPQLLFGK GYQPKMLGYAVGFNIVKKYLTASKASTADGLSIPAETFLDAML*" /label="yjaZ CDS" gene 1128938..1129723 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /label="yjaZ gene" promotor_-10 1128943..1128961 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1128955 /Source="Nicolas_upshifts" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1129724..1129808 /Source="Nicolas_S_feature" /locus_tag="new_1211286_1211370" /HighExp="S6, S5, S8, S7, BT, S4, S3, B36, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S402" promotor_-10 complement(1129740..1129758) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1129757) /Source="Nicolas_upshifts" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1129773..1129778) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1129776..1129783 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1129798..1129817 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1129810..1129914 /Source="Nicolas_S_feature" /locus_tag="new_1211372_1211476" /HighExp="LoTm, T4.0H, T3.0H, T5.0H, T3.30H, T2.30H, M9-stat, S1, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S403" upshifts 1129810 /Source="Nicolas_upshifts" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1129915..1130901 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389018.1" /db_xref="EnsemblGenomes-Gn:BSU11360" /db_xref="EnsemblGenomes-Tr:CAB12993" /db_xref="GOA:P42064" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11085" /db_xref="UniProtKB/Swiss-Prot:P42064" /translation="MSTLLEVNNLKTYFFRKKEPIPAVDGVDFHISKGETVALVGESG SGKSITSLSIMGLVQSSGGKIMDGSIKLEDKDLTSFTENDYCKIRGNEVSMIFQEPMT SLNPVLTIGEQITEVLIYHKNMKKKEARQRAVELLQMVGFSRAEQIMKEYPHRLSGGM RQRVMIAIALSCNPKLLIADEPTTALDVTIQAQVLELMKDLCQKFNTSILLITHDLGV VSEAADRVIVMYCGQVVENATVDDLFLEPLHPYTEGLLTSIPVIDGEIDKLNAIKGSV PTPDNLPPGCRFAPRCPKAMDKCWTNQPSLLTHKSGRTVRCFLYEEEGAEQS*" /label="appD CDS" gene 1129915..1130901 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /label="appD gene" CDS 1130898..1131887 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389019.2" /db_xref="EnsemblGenomes-Gn:BSU11370" /db_xref="EnsemblGenomes-Tr:CAB12994" /db_xref="GOA:P42065" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11086" /db_xref="UniProtKB/Swiss-Prot:P42065" /translation="MTAANQETILELRDVKKYFPIRSGLFQRKVGDVKAVDGVSFSLK KGETLGIVGESGCGKSTAGRTMIRLYKPTEGQILFKGQDISNLSEEKLRKSVRKNIQM VFQDPFASLNPRKTLRSIIKEPFNTHNMYTMRERNEKVEELLARVGLHPSFAGRYPHE FSGGQRQRIGIARALTLNPELIIADEPVSALDVSIQAQVINLMEELQEEFNLTYLFIS HDLSVVRHISDRVGVMYLGKMMELTGKHELYDNPLHPYTQALLSSVPVTRKRGSVKRE RIVLKGELPSPANPPKGCVFHTRCPVAKPICKEQIPEFKEAAPSHFVACHLYS*" /label="appF CDS" gene 1130898..1131887 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /label="appF gene" misc_feature 1131893..1131899 /Source="Nicolas_upshift_promotors" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1131898..1131974 /Source="Nicolas_S_feature" /locus_tag="new_1213460_1213536" /HighExp="T2.0H, S1, M9-stat, T5.0H, T3.0H, T1.30H, S2, M0t90, T2.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="SigK" /TUlongPSig=1 /label="S404" upshifts 1131898 /Source="Nicolas_upshifts" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1131975..1132466 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15588833, 25355936; Product type rc: receptor" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); N-terminal part of AppA" /translation="MKRRKTALMMLSVLMVLAIFLSACSGSKSSNSSAKKSAGKPQQG GDLVVGSIGEPTLFNSLYSTDDASTDIENMLYSFLTKTDEKLNVKLSLAESIKELDGG LAYDVKIKKGVKFHDGKELTADDVVFTYSVPLSKDYKGERGSTYEMLKSVEKKAITKS CLS*" /label="appAn CDS" gene 1131975..1132466 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /pseudo /label="appAn gene" CDS 1132439..1133605 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7997159, 15588833, 26728191; Product type lp: lipoprotein" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); C-terminal part of AppA" /translation="GDYEVLFKLKYKDGNFYNNALDSTAILPKHILGNVPIADLEENE FNRKKPIGSGPFKFKEWKQGQYIKLEANDDYFEGRPYLDTVTYKVIPDANAAVAQLQA GDINFFNVPATDYKTAEKFNNLKIVTDLALSYVYIGWNEKNELFKDKKVRQALTTALD RESIVSQVLDGDGEVAYIPESPLSWNYPKDIDVPKFEYNEKKAKQMLAEAGWKDTNGD GILDKDGKKFSFTLKTNQGNKVREDIAVVVQEQLKKIGIEVKTQIVEWSALVEQMNPP NWDFDAMVMGWSLSTFPDQYDIFHSSQIKKGLNYVWYKNAEADKLMKDAKSISDRKQY SKEYEQIYQKIAEDQPYTFLYYPNNHMAMPENLEGYKYHPKRDLYNIEKWWLAK*" /label="appAc CDS" gene 1132439..1133605 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /pseudo /label="appAc gene" downshifts 1133596 /Source="Nicolas_upshifts" /id="D618" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="7.71397" /MaxDrop="3.11667" /score="-1.00317393" /energy="-13.3" /TU="U916,U917" /idTUdmin="U913" /TUdmin=1715 /isTUend="FALSE" /label="downshifts" CDS 1133681..1134631 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389021.2" /db_xref="EnsemblGenomes-Gn:BSU11390" /db_xref="EnsemblGenomes-Tr:CAB12996" /db_xref="GOA:P42062" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11088" /db_xref="UniProtKB/Swiss-Prot:P42062" /translation="MAAYIIRRTLMSIPILLGITILSFVIMKAAPGDPMTLMMDPKIS QADREQFIEKYGLNDPQYVQYLKWLGNMVQGDFGTSIVRKGTPVSELIMARLPNTLLL MLVSTILALMISIPFGVLSAKRPYSKIDYGITFTSFIGLAIPNFWFGLILIMVLSVNL GWFPTGGVETLNTEFNIFDRIHHLILPAFVLATADMAGLTRYTRSNMLDVLNQDYIRT ARAKGFKENRVLFKHGLRNALLPVITIFGLMIPSFIGGSVVVEQIFTWPGLGKLFVDS AFQRDYPVIMAMTVISAVLVVVGNLIADILYAIVDPRIEY*" /label="appB CDS" gene 1133681..1134631 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /label="appB gene" CDS 1134648..1135559 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389022.1" /db_xref="EnsemblGenomes-Gn:BSU11400" /db_xref="EnsemblGenomes-Tr:CAB12997" /db_xref="GOA:P42063" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11089" /db_xref="UniProtKB/Swiss-Prot:P42063" /translation="MSELQTTPSPEIRLKENISKKPETMTKIFWEKFSKNKLAILGAV ILFIIIMSAVFAPLIAPYPQEQQSLLDKYKAPGLEHLMGTDKFGRDIFSRILYGARVS LLVGFASVVGSILIGTVLGALAGYFRGIVDAVIMRVVDIVLSIPDIFLLITLVTIFKP GVDKLILIFCLTGWTTTARLVRGEFLSLRSREYVLAAKTIGTKTHKIIFSHILPNALG PIIVSATLKVGSVILAESALSYLGFGIQPPIASWGNMLQDAQNFTVMIQAWWYPLFPG LFILMTVLCFNFVGDGLRDALDPKNIK*" /label="appC CDS" gene 1134648..1135559 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /label="appC gene" downshifts 1135573 /Source="Nicolas_upshifts" /id="D619" /incds=0 /nref=62 /ntot=188 /MaxReadThrough="5.13927" /MaxDrop="5.50153" /score="22.0028545" /energy="-11.6" /TU="U916,U917" /idTUdmin="U916" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" S_feature 1135618..1135725 /Source="Nicolas_S_feature" /locus_tag="new_1217180_1217287" /HighExp="LoTm, S1, S2, BT, T3.30H, T4.0H, T5.0H, T3.0H, Glu, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S405" promotor_-35 1135698..1135703 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1135719..1135737 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1135727 /Source="Nicolas_upshifts" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1135764..1136516 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717292, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation nucleic acid binding protein" /protein_id="NP_389023.1" /db_xref="EnsemblGenomes-Gn:BSU11410" /db_xref="EnsemblGenomes-Tr:CAB12998" /db_xref="InterPro:IPR020909" /db_xref="SubtiList:BG13130" /db_xref="UniProtKB/Swiss-Prot:O31597" /translation="MLFLHDVWVNWFEGEENGYNVCHFHEWRKEDTVELLDQVPLLRV PSVLFHYIENDLSELPKGLLEDVHQKSYIRKNHERTKLEYCFVVTDGIGILAVDTIGY TIPVRKSRLIPRQEQLVYEMVKDVEPETYEFEPKKLESSKEYHILSLAPEHVRGLTRK ERQIKQLMFMALDQLKGLKNRAEIGYWYTEWNPHMYEQIKRMSFEEIWDMLYNETIEG WSDKHLAFCENLIKGQPFFEKLWEMENESKVN*" /label="yjbA CDS" gene 1135764..1136516 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /label="yjbA gene" downshifts 1136496 /Source="Nicolas_upshifts" /id="D620" /incds=0 /nref=32 /ntot=112 /MaxReadThrough="1.07428" /MaxDrop="6.2264" /score="22.0028545" /energy="-11.6" /TU="NA" /idTUdmin="U916" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1136551..1137543) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /EC_number="6.1.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8950174, 10706627, 12682299, 24572018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8950174, 10706627, 12682299, 24572018; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophanyl-tRNA synthetase" /protein_id="NP_389024.1" /db_xref="EnsemblGenomes-Gn:BSU11420" /db_xref="EnsemblGenomes-Tr:CAB12999" /db_xref="GOA:P21656" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002306" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024109" /db_xref="PDB:3PRH" /db_xref="SubtiList:BG10799" /db_xref="UniProtKB/Swiss-Prot:P21656" /translation="MKQTIFSGIQPSGSVTLGNYIGAMKQFVELQHDYNSYFCIVDQH AITVPQDRLELRKNIRNLAALYLAVGLDPEKATLFIQSEVPAHAQAGWMMQCVAYIGE LERMTQFKDKSKGNEAVVSGLLTYPPLMAADILLYGTDLVPVGEDQKQHLELTRNLAE RFNKKYNDIFTIPEVKIPKVGARIMSLNDPLKKMSKSDPNQKAYITLLDEPKQLEKKI KSAVTDSEGIVKFDKENKPGVSNLLTIYSILGNTTIEELEAKYEGKGYGEFKGDLAEV VVNALKPIQDRYYELIESEELDRILDEGAERANRTANKMLKKMENAMGLGRKRR*" /label="trpS CDS" gene complement(1136551..1137543) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /label="trpS gene" downshifts complement(1136572) /Source="Nicolas_upshifts" /id="D621" /incds=0 /nref=224 /ntot=255 /MaxReadThrough="1.77115" /MaxDrop="6.72647" /score="27.6275522" /energy="-11.6" /TU="U919" /idTUdmin="U919" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" misc_RNA complement(1137602..1137816) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /product="T-box riboswitch specific of tryptophan tRNA" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboWA RNA" gene complement(1137602..1137816) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /label="tboWA gene" downshifts complement(1137650) /Source="Nicolas_upshifts" /id="D622" /incds=0 /nref=37 /ntot=127 /MaxReadThrough="6.8472" /MaxDrop="5.13001" /score="25.1445248" /energy="-19" /TU="U919" /idTUdmin="U919" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" misc_feature complement(1137835..1137854) /Source="Nicolas_upshift_promotors" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1137848) /Source="Nicolas_upshifts" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1138103..1138110 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1138124..1138286 /Source="Nicolas_S_feature" /locus_tag="new_1219686_1219848" /HighExp="S1, T3.0H, T3.30H, T2.30H, T4.0H, T5.0H, LoTm, T2.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S406" promotor_-10 1138125..1138144 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1138125 /Source="Nicolas_upshifts" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1138287..1139924 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (binding lipoprotein)" /protein_id="NP_389025.1" /db_xref="EnsemblGenomes-Gn:BSU11430" /db_xref="EnsemblGenomes-Tr:CAB13000" /db_xref="GOA:P24141" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10771" /db_xref="UniProtKB/Swiss-Prot:P24141" /translation="MKKRWSIVTLMLIFTLVLSACGFGGSGSNGEGKKDSKGKTTLNI NIKTEPFSLHPGLANDSVSGGVIRQTFEGLTRINADGEPEEGMASKIETSKDGKTYTF TIRDGVKWSNGDPVTAQDFEYAWKWALDPNNESQYAYQLYYIKGAEAANTGKGSLDDV AVKAVNDKTLKVELNNPTPYFTELTAFYTYMPINKKIAEKNKKWNTNAGDDYVSNGPF KMTAWKHSGSITLEKNDQYWDKDKVKLKKIDMVMINNNNTELKKFQAGELDWAGMPLG QLPTESLPTLKKDGSLHVEPIAGVYWYKFNTEAKPLDNVNIRKALTYSLDRQSIVKNV TQGEQIPAMAAVPPTMKGFEDNKEGYFKDNDVKTAKEYLEKGLKEMGLSKASDLPKIK LSYNTDDAHAKIAQAVQEMWKKNLGVDVELDNSEWNVYIDKLHSQDYQIGRMGWLGDF NDPINFLELFRDKNGGNNDTGWENPEFKKLLNQSQTETDKTKRAELLKKAEGIFIDEM PVAPIYFYTDTWVQDENLKGVIMPGTGEVYFRNAYFK*" /label="oppA CDS" gene 1138287..1139924 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /label="oppA gene" downshifts 1139818 /Source="Nicolas_upshifts" /id="D623" /incds=1 /nref=8 /ntot=166 /MaxReadThrough="6.94127" /MaxDrop="3.3677" /score="-4.2761508" /energy="-15.6" /TU="U920" /idTUdmin="U916" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 1139925..1140031 /Source="Nicolas_S_feature" /locus_tag="new_1221487_1221593" /HighExp="S1, LoTm, T4.0H, BT, T3.30H, T3.0H, T5.0H, M0t90, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S407" CDS 1140032..1140967 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 17600541, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 17600541, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389026.1" /db_xref="EnsemblGenomes-Gn:BSU11440" /db_xref="EnsemblGenomes-Tr:CAB13001" /db_xref="GOA:P24138" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10772" /db_xref="UniProtKB/Swiss-Prot:P24138" /translation="MLKYIGRRLVYMIITLFVIVTVTFFLMQAAPGGPFSGEKKLPPE IEANLNAHYGLDKPLFVQYVSYLKSVAMWDFGPSFKYKGQSVNDLISSGFPVSFTLGA EAILLALALGVLFGVIAALYHNKWQDYTVAILTIFGISVPSFIMAAVLQYVFSMKLGL FPVAGWDSWAYTFLPSIALASMPMAFIARLSRSSMIEVLNSDYIRTAKAKGLSRPAVT VRHAIRNALLPVVTYMGPMAAQVLTGSFIIETIFGIPGLGAHFVNSITNRDYTVIMGV TVFFSVILLLCVLIVDVLYGIIDPRIKLSKAKKGA*" /label="oppB CDS" gene 1140032..1140967 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /label="oppB gene" promotor_-10 complement(1140075..1140094) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1140092) /Source="Nicolas_upshifts" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1140110..1140116) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1140971..1141888 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 26782429" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 26782429; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389027.1" /db_xref="EnsemblGenomes-Gn:BSU11450" /db_xref="EnsemblGenomes-Tr:CAB13002" /db_xref="GOA:P24139" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10773" /db_xref="UniProtKB/Swiss-Prot:P24139" /translation="MQNIPKNMFEPAAANAGDAEKISKKSLSLWKDAMLRFRSNKLAM VGLIIIVLIILMAIFAPMFSRYDYSTTNLLNADKPPSKDHWFGTDDLGRDIFVRTWVG ARISIFIGVAAAVLDLLIGVIWGSISGFRGGRTDEIMMRIADILWAVPSLLMVILLMV VLPKGLFTIIIAMTITGWINMARIVRGQVLQLKNQEYVLASQTLGAKTSRLLFKHIVP NAMGSILVTMTLTVPTAIFTEAFLSYLGLGVPAPLASWGTMASDGLPALTYYPWRLFF PAGFICITMFGFNVVGDGLRDALDPKLRK*" /label="oppC CDS" gene 1140971..1141888 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /label="oppC gene" CDS 1141893..1142969 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 19202088, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 19202088, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389028.1" /db_xref="EnsemblGenomes-Gn:BSU11460" /db_xref="EnsemblGenomes-Tr:CAB13003" /db_xref="GOA:P24136" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10774" /db_xref="UniProtKB/Swiss-Prot:P24136" /translation="MIRVTRLLEVKDLAISFKTYGGEVQAIRGVNFHLDKGETLAIVG ESGSGKSVTSQAIMKLIPMPPGYFKRGEILFEGKDLVPLSEKEMQNVRGKEIGMIFQD PMTSLNPTMKVGKQITEVLFKHEKISKEAAKKRAVELLELVGIPMPEKRVNQFPHEFS GGMRQRVVIAMALAANPKLLIADEPTTALDVTIQAQILELMKDLQKKIDTSIIFITHD LGVVANVADRVAVMYAGQIVETGTVDEIFYDPRHPYTWGLLASMPTLESSGEEELTAI PGTPPDLTNPPKGDAFALRSSYAMKIDFEQEPPMFKVSDTHYVKSWLLHPDAPKVEPP EAVKAKMRKLANTFEKPVLVREVE*" /label="oppD CDS" gene 1141893..1142969 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /label="oppD gene" CDS 1142971..1143888 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 7997159, 11401703, 23133654, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 7997159, 11401703, 23133654, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389029.1" /db_xref="EnsemblGenomes-Gn:BSU11470" /db_xref="EnsemblGenomes-Tr:CAB13004" /db_xref="GOA:P24137" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10775" /db_xref="UniProtKB/Swiss-Prot:P24137" /translation="MTEKLLEIKHLKQHFVTPRGTVKAVDDLSFDIYKGETLGLVGES GCGKSTTGRSIIRLYEATDGEVLFNGENVHGRKSRKKLLEFNRKMQMIFQDPYASLNP RMTVADIIAEGLDIHKLAKTKKERMQRVHELLETVGLNKEHANRYPHEFSGGQRQRIG IARALAVDPEFIIADEPISALDVSIQAQVVNLMKELQKEKGLTYLFIAHDLSMVKYIS DRIGVMYFGKLVELAPADELYENPLHPYTKSLLSAIPLPDPDYERNRVRQKYDPSVHQ LKDGETMEFREVKPGHFVMCTEAEFKAFS*" /label="oppF CDS" gene 1142971..1143888 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /label="oppF gene" downshifts 1143858 /Source="Nicolas_upshifts" /id="D624" /incds=0 /nref=21 /ntot=196 /MaxReadThrough="1.58906" /MaxDrop="5.17491" /score="28.2861081" /energy="-15.2" /TU="NA" /idTUdmin="U920" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 1143938..1143941 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1143954 /Source="Nicolas_upshifts" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1143956..1143975 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1143995..1145212 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563878, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_389030.2" /db_xref="EnsemblGenomes-Gn:BSU11480" /db_xref="EnsemblGenomes-Tr:CAB13005" /db_xref="GOA:O31600" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13131" /db_xref="UniProtKB/Swiss-Prot:O31600" /translation="MQFLHNKNVFALLLSQSFQSLAGVLVTIVLMVRIYQMTDSVFLA GLILSFMSFASIAASFCVSPVLRILGFKKVLAGANLLRAVFIILMAYSVTHHGQAFFW ITLLFVFCFSFAGAFFQPARFALLPIIVPKKQYVKANGVISLSNQLFLTAGWGLGGLL TYAVPFELVVGAAICLFVLSGASISVLHVNEEEAAGTAETASVRSIWKDLMIIPIVRD ITVMDMLEALAGSVWSSAILLAFTAAVLHETEVWWGMFNASYFIGAIVGSVIAIRFSS FFERNMGYAIMFSSLVMSALTLLFSFSPVPFLCALACAAMGPFYQVRDICQETMLQEV IPEQKRIGIMAAKNAILTPWSGVTYSIMGLVADAAGAKIAFIAAAALYIMTFLIALAQ PRLVHYRRENRVQ*" /label="yjbB CDS" gene 1143995..1145212 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /label="yjbB gene" promotor_-35 1145265..1145274 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-35" promotor_-10 1145287..1145302 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-10" S_feature 1145296..1145375 /Source="Nicolas_S_feature" /locus_tag="new_1226858_1226937" /HighExp="Etha, B60, M9-stat, T0.30H, Salt, T3.0H, T1.0H, T4.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S408" upshifts 1145296 /Source="Nicolas_upshifts" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="upshifts" CDS 1145376..1145954 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17158660, 17158663, 21815947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol oxidation management factor; putative acetyltransferase" /protein_id="NP_389031.2" /db_xref="EnsemblGenomes-Gn:BSU11490" /db_xref="EnsemblGenomes-Tr:CAB13006" /db_xref="GOA:O31601" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13132" /db_xref="UniProtKB/Swiss-Prot:O31601" /translation="MNWYEKLSEYFPIEEMKSKAHMEALLKERSDIYHKDEGKHHILM FAEFDSFIFVDYLYVSKDARGQGLGGKLIAKLKKKNKPILLEVEPVDEDDTDTEKRLR FYQREHFKHAQSIGYRRRSLATNEVNKMEILYWSPKTESEEEILEAMKQTYENIHTYK DEKWYGESYEKTDEVLEIIDEEKQKNIFDQLS*" /label="yjbC CDS" gene 1145376..1145954 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /label="yjbC gene" S_feature 1145955..1146069 /Source="Nicolas_S_feature" /locus_tag="new_1227517_1227631" /HighExp="B60, Etha, Salt, T0.30H, M9-stat, LoTm, Gly, T1.0H, B36, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S409" promotor_-10 complement(1146006..1146025) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1146010) /Source="Nicolas_upshifts" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1146039..1146046) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1146072..1146085 /Source="Nicolas_upshift_promotors" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1146072 /Source="Nicolas_upshifts" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="upshifts" CDS 1146135..1146530 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="redox-sensitive regulator" /protein_id="NP_389032.1" /db_xref="EnsemblGenomes-Gn:BSU11500" /db_xref="EnsemblGenomes-Tr:CAB13007" /db_xref="GOA:O31602" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR023731" /db_xref="InterPro:IPR036249" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG13133" /db_xref="UniProtKB/Swiss-Prot:O31602" /translation="MVTLYTSPSCTSCRKARAWLEEHEIPFVERNIFSEPLSIDEIKQ ILRMTEDGTDEIISTRSKVFQKLNVNVESMPLQDLYRLINEHPGLLRRPIIIDEKRLQ VGYNEDEIRRFLPRKVRSFQLREAQRLAN*" /label="spxA CDS" gene 1146135..1146530 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /label="spxA gene" promotor_no_box complement(1146366..1146466) /Source="Nicolas_upshift_promotors" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1146406) /Source="Nicolas_upshifts" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1146528 /Source="Nicolas_upshifts" /id="D625" /incds=0 /nref=263 /ntot=269 /MaxReadThrough="4.34531" /MaxDrop="8.0579" /score="7.42972561" /energy="-8.8" /TU="U923" /idTUdmin="U925" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1146573..1147362 /Source="Nicolas_S_feature" /locus_tag="new_1228135_1228924" /HighExp="B60, B36, Etha, M9-stat, Salt, H2O2, Paraq, Cold, G180, G135" /AntisenseName="yjbE" /AntisenseCor="-0.18634010398760401" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S410" CDS complement(1146573..1147229) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389033.1" /db_xref="EnsemblGenomes-Gn:BSU11510" /db_xref="EnsemblGenomes-Tr:CAB13008" /db_xref="GOA:O31603" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022301" /db_xref="SubtiList:BG13134" /db_xref="UniProtKB/Swiss-Prot:O31603" /translation="MEHDYLISLLVIVGIDLILGGDNAVVIAMASRHLPDKQRQQAII LGTFIAVAMRIGLTSAAVYLLNIPFLQCAGGIFLLYLGYQLLIEKKDTKHIKSSTSLW RAIRTIVLADLFMSLDNVIAVAGASHGEFSLVVIGLCVSVPVIIWGSKLIHIALEKIP LLIYAGSGLLAYTGGEMIVRDKKLSLFMAQHGTVETLLPILTVAFVILASIYYQQVEK *" /label="yjbE CDS" gene complement(1146573..1147229) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /label="yjbE gene" promotor_-10 complement(1147259..1147277) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1147274) /Source="Nicolas_upshifts" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1147292..1147297) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1147335..1147342 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1147356..1147375 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1147364..1147505 /Source="Nicolas_S_feature" /locus_tag="new_1228926_1229067" /HighExp="B60, Diami, Etha, dia5, LPhT, M9-stat, T5.0H, T3.0H, dia15, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S411" upshifts 1147364 /Source="Nicolas_upshifts" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="upshifts" CDS 1147399..1147539 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513949.1" /translation="MVKVKMWTEWVKCSKVQLIGSLDVPSTSYIEGKVGKWKLKELTS IQ*" /label="conserved hypothetical protein CDS" gene 1147399..1147539 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /label="gene" CDS 1147506..1148162 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10361283, 10447896, 16525504, 19801546, 21435029, 23595989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 10447896, 16525504, 19801546, 21435029, 23595989; Product type f : factor" /codon_start=1 /transl_table=11 /product="adaptor protein controlling oligomerization of the AAA+ protein ClpC" /protein_id="NP_389034.1" /db_xref="EnsemblGenomes-Gn:BSU11520" /db_xref="EnsemblGenomes-Tr:CAB13009" /db_xref="GOA:P37958" /db_xref="InterPro:IPR008681" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3JTP" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="SubtiList:BG10680" /db_xref="UniProtKB/Swiss-Prot:P37958" /translation="MEIERINEHTVKFYMSYGDIEDRGFDREEIWYNRERSEELFWEV MDEVHEEEEFAVEGPLWIQVQALDKGLEIIVTKAQLSKDGQKLELPIPEDKKQEPASE DLDALLDDFQKEEQAVNQEEKEQKLQFVLRFGDFEDVISLSKLNVNGSKTTLYSFENR YYLYVDFCNMTDEEVENQLSILLEYATESSISIHRLEEYGKLIISEHALETIKKHFAS *" /label="mecA CDS" gene 1147506..1148162 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /label="mecA gene" downshifts 1148152 /Source="Nicolas_upshifts" /id="D626" /incds=0 /nref=120 /ntot=308 /MaxReadThrough="5.41786" /MaxDrop="7.67172" /score="32.2431225" /energy="-11.8" /TU="U928" /idTUdmin="U928" /TUdmin="-774" /isTUend="FALSE" /label="downshifts" CDS complement(1148157..1148279) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513950.1" /translation="MINSCSLYFLLVYMFLIFHISKMAFSCIKKTDFRKEIGLL*" /label="conserved hypothetical protein CDS" gene complement(1148157..1148279) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /label="gene" S_feature 1148197..1148286 /Source="Nicolas_S_feature" /locus_tag="new_1229759_1229848" /HighExp="Etha, M9-stat, B60, dia15, T0.30H, Diami, C30, H2O2, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S412" promotor_-35 1148265..1148273 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1148284..1148302 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1148288..1148352 /Source="Nicolas_S_feature" /locus_tag="new_1229850_1229914" /HighExp="Etha, G/S, GM 150, T-4.40H, S2, T-2.40H, Pyr, C90, M9-tran, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.876, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S413" upshifts 1148288 /Source="Nicolas_upshifts" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1148353..1149474 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10438773, 17630974, 23046409, 26880300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438773, 17630974, 23046409, 26880300; Product type s: structure" /codon_start=1 /transl_table=11 /product="protein involved in establishment of DNA transport in competence" /protein_id="NP_389035.1" /db_xref="EnsemblGenomes-Gn:BSU11530" /db_xref="EnsemblGenomes-Tr:CAB13010" /db_xref="GOA:O31604" /db_xref="InterPro:IPR010330" /db_xref="InterPro:IPR021176" /db_xref="SubtiList:BG13135" /db_xref="UniProtKB/Swiss-Prot:O31604" /translation="MFHLLGAQQNQKLKRRRFFCPVCGGELAVKLGLQKAPHFAHKQN KSCAIDIEPESAYHLEGKRQLYVWLKTQRASPILEPYIRTINQRPDVMARIKEHMLAV EYQCATIAPDVFQKRTEGFKQEGIIPQWIMGYSRLKRTASSFYQLSTFHWQFINASPY RELICYCPERRSFLRLSHIIPFYTNHSYSSVQTIPIHRAGAGDLFFTEPKPSIQYSGW TKAIHRFRHKPHRFNSKETNRLRLLFYEKRQTPFSFLPTEVFVPVRKGAVFKSPVFVW QGFLYLFMTDLGGKRAPIRFSAVLQQCKLHIHNKNIALRSECSEECLSEAVKQYIDFL CKKGFLRETQKEVYVLNQPAGGIHSMQDLIERDRSCFIE*" /label="coiA CDS" gene 1148353..1149474 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /label="coiA gene" promotor_-35 1149128..1149134 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" upshifts 1149146 /Source="Nicolas_upshifts" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-10 1149149..1149167 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" promotor_-35 1149360..1149368 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" promotor_-10 1149380..1149398 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" upshifts 1149387 /Source="Nicolas_upshifts" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-35 1149468..1149474 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1149489..1149500 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1149498 /Source="Nicolas_upshifts" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1149521..1151533 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11741842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11741842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoendopeptidase F" /protein_id="NP_389036.2" /db_xref="EnsemblGenomes-Gn:BSU11540" /db_xref="EnsemblGenomes-Tr:CAB13011" /db_xref="GOA:O31605" /db_xref="InterPro:IPR001567" /db_xref="InterPro:IPR004438" /db_xref="InterPro:IPR013647" /db_xref="SubtiList:BG13136" /db_xref="UniProtKB/Swiss-Prot:O31605" /translation="MKGTKGKVFRVFTAFLAFVLFITAYDLTKGSEKPEDIHNTSLLR NSCFFNWLESKKTRGITMAEEKKANQLPDRSEVKAEDTWRLEDIFPSDEAWNKEFQAV KELIPNLSKYKGKLADSADHLYEALTYQDKVMERLGRLYTYAHMRSDQDTGNSFYQGL NDKAGNLYTQAASATAYLVPEILSIEEDKLQQFILEKEELKLYSHAIEEITKERPHVL SEKEEALLAEASEVLGSSSNTFSVLNNADITFPSIKDEDGNEKQITHGNFINFLESEN REVRKNAFDAVYKTYGQYKNTMATTLSGTVKKDNFYARVKKYKSAREAALSNNSIPEE VYDNLVKTINKHLPLLHRYIALRKKVLELDEVHIYDLYTPLVKDAGMKVTYEEAKDYM LKGLAPLGEEYASILKEGLENRWVDVYENKGKRNGAYSSGAYGTNPYILMNWHNNVNN LFTLVHEFGHSVHSYYTRKHQPYPYGNYSIFVAEVASTTNEALLGEYLLNNLEDEKQR LYILNHMLEGFRGTVFRQTMFAEFEHLIHTKAQEGEPLTPELLTNVYYDLNKKYFGDG MVIDKEIGLEWSRIPHFYYNYYVYQYATGYSAAQALSSQILKEGKPAVDRYIDFLKAG SSQYPIDVLKKAGVDMTSPEPIEAACKMFEEKLDEMEELLMKVKQS*" /label="pepF CDS" gene 1149521..1151533 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /label="pepF gene" promotor_-35 1149596..1149603 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-35" promotor_-10 1149618..1149637 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-10" upshifts 1149630 /Source="Nicolas_upshifts" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="upshifts" downshifts 1151480 /Source="Nicolas_upshifts" /id="D627" /incds=0 /nref=98 /ntot=339 /MaxReadThrough="4.70576" /MaxDrop="5.74441" /score="19.0969124" /energy="-15.2" /TU="U933" /idTUdmin="U931" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 1151534..1151835 /Source="Nicolas_S_feature" /locus_tag="new_1233096_1233397" /HighExp="Etha, dia15, Diami, B60, M9-stat, S8, M0t90, dia5, B36, T0.30H" /AntisenseName="yizD" /AntisenseCor="-1.29003203536192E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="SigH, SigB" /TUlongPSig="0.999, 0.999" /label="S414" CDS complement(1151571..1151738) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097703.1" /db_xref="EnsemblGenomes-Gn:BSU11549" /db_xref="EnsemblGenomes-Tr:CAX52593" /db_xref="GOA:C0H3Y6" /db_xref="UniProtKB/Swiss-Prot:C0H3Y6" /translation="MMSTLISIVCIAVFFCLNILGMMHMLPLYITSPLLFLSILFTLY RLNHRKTFKGF*" /label="yizD CDS" gene complement(1151571..1151738) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /label="yizD gene" downshifts complement(1151584) /Source="Nicolas_upshifts" /id="D628" /incds=0 /nref=8 /ntot=61 /MaxReadThrough="1.527" /MaxDrop="5.54041" /score="-4.56163992" /energy="-15.2" /TU="NA" /idTUdmin="U934" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1151758..1151776) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1151774) /Source="Nicolas_upshifts" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1151792..1151797) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1151828..1151835 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1151837..1151962 /Source="Nicolas_S_feature" /locus_tag="new_1233399_1233524" /HighExp="B36, T-1.10H, nit, T-0.40H, M9-tran, LoTm, Pyr, Etha, Salt, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.883" /TUlongSig="SigA, SigH, SigB" /TUlongPSig="0.926, 0.999, 0.999" /label="S415" upshifts 1151837 /Source="Nicolas_upshifts" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1151843..1151981 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /product="small regulatory RNA (NO regulated)" /experiment="publication(s) with functional evidences, PMID:19682248, 19786493, 20511587, 20525796, 25643072, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682248, 19786493, 20511587, 20525796, 25643072, 28436820; Product type n : RNA" /label="roxS RNA" gene 1151843..1151981 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /label="roxS gene" promotor_-10 1151850..1151869 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1151919 /Source="Nicolas_upshifts" /id="D629" /incds=0 /nref=96 /ntot=135 /MaxReadThrough="3.50613" /MaxDrop="9.07209" /score="5.30186633" /energy="-11.6" /TU="U935" /idTUdmin="U933" /TUdmin=89 /isTUend="FALSE" /label="downshifts" CDS complement(1152052..1152951) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiol management effector of SpxA degradation" /protein_id="NP_389037.2" /db_xref="EnsemblGenomes-Gn:BSU11550" /db_xref="EnsemblGenomes-Tr:CAB13012" /db_xref="GOA:O31606" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13137" /db_xref="UniProtKB/Swiss-Prot:O31606" /translation="MTNYQHELYFAHCHGHPKKPLEIYMFVDPLCPECWSLEPVIKKL KIRYGRFFTLRIIASASLTALNKKRKKHLLAEAWEKIASRSGMSCDGNVWFEQDQPLS SPYMAALAFKAAELQGRKAGMQFLRNMQESLFVSKKNITDENVLLEIAENTSLDLEEF KKDLHSQSAVKALQCDMKIAAEMDVSVNPTLTFFNTQHEDEGLKVPGSYSYDVYEEIL FEMLGDEPKPSETPPLECFIEYFRFVASKEIALVYDLSLEEVEKEMKKLAFAKKVAKV EAKHGMFWKSLSTYSDEYQSCEK*" /label="spxH CDS" gene complement(1152052..1152951) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /label="spxH gene" downshifts complement(1152083) /Source="Nicolas_upshifts" /id="D630" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="3.70729" /MaxDrop="5.65601" /score="17.9327625" /energy="-13.3" /TU="U937" /idTUdmin="U937" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1152287..1152292 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1152299 /Source="Nicolas_upshifts" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1152308..1152326 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1152315..1154216 /Source="Nicolas_S_feature" /locus_tag="new_1233877_1235778" /HighExp="S6, S4, S5, S8, S3, S7, BT, B36, C30, T5.0H" /AntisenseName="yjbH" /AntisenseCor="-0.61019541931037402" /AntisenseRegPval="-28.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S416" CDS complement(1152948..1153346) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15866723, 17293416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol management oxidoreductase component" /protein_id="NP_389038.1" /db_xref="EnsemblGenomes-Gn:BSU11560" /db_xref="EnsemblGenomes-Tr:CAB13013" /db_xref="GOA:O31607" /db_xref="InterPro:IPR001486" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR019795" /db_xref="PDB:1UX8" /db_xref="SubtiList:BG13138" /db_xref="UniProtKB/Swiss-Prot:O31607" /translation="MGQSFNAPYEAIGEELLSQLVDTFYERVASHPLLKPIFPSDLTE TARKQKQFLTQYLGGPPLYTEEHGHPMLRARHLPFPITNERADAWLSCMKDAMDHVGL EGEIREFLFGRLELTARHMVNQTEAEDRSS*" /label="yjbI CDS" gene complement(1152948..1153346) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /label="yjbI gene" S_feature complement(1153347..1153526) /Source="Nicolas_S_feature" /locus_tag="new_1234909_1235088_c" /HighExp="Diami, dia5, dia15, Etha, H2O2, C90, LoTm, Heat, Salt, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.999" /label="S417" promotor_-10 complement(1153518..1153537) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1153526) /Source="Nicolas_upshifts" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1153549..1153556) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1153601..1154146) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /EC_number="3.2.1.-" /EC_number="3.2.1.17" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:20609359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20609359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional muramidase and murein lytic transglycosylase" /protein_id="NP_389039.1" /db_xref="EnsemblGenomes-Gn:BSU11570" /db_xref="EnsemblGenomes-Tr:CAB13014" /db_xref="GOA:O31608" /db_xref="InterPro:IPR000189" /db_xref="InterPro:IPR008258" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13139" /db_xref="UniProtKB/Swiss-Prot:O31608" /translation="MLNSANTTAPSLLSAYGLNSYTSSNSGSVTKAAESTETAVADSA SNKHEANQIRSGDFSIDSAIKKAADKYGVDEKLIRAVIKQESGFNAKAVSGAGAMGLM QLMPSTASSLGVSNPLDPQQNVEGGTKYLKQMLDKYDGNVSMALAAYNAGPGNVDRYG GIPPFQETQNYVKKITSVYYA*" /label="cwlQ CDS" gene complement(1153601..1154146) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /label="cwlQ gene" downshifts complement(1153625) /Source="Nicolas_upshifts" /id="D631" /incds=0 /nref=101 /ntot=222 /MaxReadThrough="4.1014" /MaxDrop="5.00847" /score="6.97790581" /energy="-9.1" /TU="U938,U939" /idTUdmin="U938" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" S_feature complement(1154147..1154349) /Source="Nicolas_S_feature" /locus_tag="new_1235709_1235911_c" /HighExp="T0.30H, Gly, C90, GM 10, GM 45, M0t90, Lbstat, C30, Lbtran, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S418" CDS complement(1154350..1154922) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9642185, 12456267, 16905149, 20509597, 26904951, 27881678; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative RNA/thiamine triphosphatase" /protein_id="NP_389040.1" /db_xref="EnsemblGenomes-Gn:BSU11580" /db_xref="EnsemblGenomes-Tr:CAB13015" /db_xref="GOA:O31609" /db_xref="InterPro:IPR009195" /db_xref="InterPro:IPR023577" /db_xref="InterPro:IPR033469" /db_xref="SubtiList:BG13140" /db_xref="UniProtKB/Swiss-Prot:O31609" /translation="MSQEIEIEFKNMLTKQEFKNIASALQLTEKDFTDQKNHYFDTDS FALKQKHAALRIRRKNGKYVLTLKEPADVGLLETHQQLSEVSDLAGFSVPEGPVKDQL HKLQIDTDAIQYFGSLATNRAEKETEKGLIVLDHSRYLNKEDYEIEFEAADWHEGRQA FEKLLQQFSIPQRETKNKILRFYEEKRKSI*" /label="yjbK CDS" gene complement(1154350..1154922) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /label="yjbK gene" promotor_-10 complement(1154495..1154513) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1154504) /Source="Nicolas_upshifts" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 complement(1154526..1154533) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" promotor_-10 complement(1154951..1154970) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1154968) /Source="Nicolas_upshifts" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 1154984..1154987 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1154985..1154992) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" upshifts 1155000 /Source="Nicolas_upshifts" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1155003..1155022 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1155047..1155415 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389041.1" /db_xref="EnsemblGenomes-Gn:BSU11590" /db_xref="EnsemblGenomes-Tr:CAB13016" /db_xref="InterPro:IPR020908" /db_xref="SubtiList:BG13141" /db_xref="UniProtKB/Swiss-Prot:O31610" /translation="MQNRIEILNATLSDDQLRLACQTEGNEAERKPSGQMLVDSDHFA FVYILELADSFEYVIIKEHVWPELKQAHAQKIPVVLEAGDQTIELAGLHEELEYLLEN IKDNANYGEEMEEKVKRVFL*" /label="yjbL CDS" gene 1155047..1155415 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /label="yjbL gene" CDS 1155444..1156079 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /EC_number="2.7.6.5" /function="16.1: Circulate" /function="16.14: Store" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 24163341, 25331430, 26825398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 24163341, 25331430, 26825398; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_389042.1" /db_xref="EnsemblGenomes-Gn:BSU11600" /db_xref="EnsemblGenomes-Tr:CAB13017" /db_xref="GOA:O31611" /db_xref="InterPro:IPR007685" /db_xref="PDB:5DEC" /db_xref="PDB:5DED" /db_xref="PDB:5F2V" /db_xref="SubtiList:BG13142" /db_xref="UniProtKB/Swiss-Prot:O31611" /translation="MDDKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVT GRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVV DQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYK YSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEAQAAFSRKKKGSEQQ*" /label="relP CDS" gene 1155444..1156079 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /label="relP gene" CDS 1156098..1156898 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /EC_number="2.7.1.23" /function="16.14: Store" /function="16.7: Manage energy" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12897004, 16233726, 16511117, 18720024, 24048943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12897004, 16233726, 16511117, 18720024, 24048943; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase (quinolate activated)" /protein_id="NP_389043.1" /db_xref="EnsemblGenomes-Gn:BSU11610" /db_xref="EnsemblGenomes-Tr:CAB13018" /db_xref="GOA:O31612" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13143" /db_xref="UniProtKB/Swiss-Prot:O31612" /translation="MKFAVSSKGDQVSDTLKSKIQAYLLDFDMELDENEPEIVISVGG DGTLLYAFHRYSDRLDKTAFVGVHTGHLGFYADWVPHEIEKLVLAIAKTPYHTVEYPL LEVIVTYHENEREERYLALNECTIKSIEGSLVADVEIKGQLFETFRGDGLCLSTPSGS TAYNKALGGAIIHPSIRAIQLAEMASINNRVFRTVGSPLLLPSHHDCMIKPRNEVDFQ VTIDHLTLLHKDVKSIRCQVASEKVRFARFRPFPFWKRVQDSFIGKGE*" /label="ppnKA CDS" gene 1156098..1156898 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /label="ppnKA gene" CDS 1156961..1157812 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /EC_number="5.4.99.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389044.1" /db_xref="EnsemblGenomes-Gn:BSU11620" /db_xref="EnsemblGenomes-Tr:CAB13019" /db_xref="GOA:O31613" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG13144" /db_xref="UniProtKB/Swiss-Prot:O31613" /translation="MTVKEYAGELGISKRLLTDIKFGGGDLQINGEHVTVKYVLKEGD LLIVKFPEEQVSETLLAEPVPLDILYEDEHVLVINKQPYVSSIPSREHPSGSIANGII DHYQTTGVRATVHLVTRLDRDTSGIMLVAKHRFAHSILSSAQKNGLVKRRYAAVVHGR MAQMEGTVDAPIGRHPDSIIERTVTPDGQKAVTHFYVTCANDDMTSVALQLETGRTHQ IRVHMSYLGHPLCGDTLYGGTRQEIGRQALHSEHLSFIHPLTQENMRFHAPLPQDMSK LIKGENH*" /label="yjbO CDS" gene 1156961..1157812 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /label="yjbO gene" downshifts 1157771 /Source="Nicolas_upshifts" /id="D632" /incds=0 /nref=203 /ntot=256 /MaxReadThrough="0.25796" /MaxDrop="5.73002" /score="21.4914497" /energy="-12.8" /TU="NA" /idTUdmin="U940" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1157825..1158559) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /EC_number="3.6.1.17" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12059787, 16740944, 21092197, 23824080, 28516732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12059787, 16740944, 21092197, 23824080, 28516732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphorylated protein phosphatase E and diadenosine-polyphosphate hydrolase" /protein_id="NP_389045.1" /db_xref="EnsemblGenomes-Gn:BSU11630" /db_xref="EnsemblGenomes-Tr:CAB13020" /db_xref="GOA:O31614" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR023937" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13145" /db_xref="UniProtKB/Swiss-Prot:O31614" /translation="MAYDIISDIHGCYDEMTALIQKLGYTIKNGVPVHEEGRVLVFAG DLTDRGPKSIEVIRFVAGAYEKGAVRYVPGNHCNKLYRYLKGNPVKVMHGLETTAAEL EELSKDEKKSVSEQFMKLYETAPLYDILHNGELVVAHAGIRADDIGKYTRRVKDFVLY GDVTGETYPDGRPIRRDWAAAYNGKAWVVYGHTPVKEPRKVNRTINIDTGCVFGNQLT GFRFPEIETVSVPSSLPYDESRFRPI*" /label="prpE CDS" gene complement(1157825..1158559) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /label="prpE gene" downshifts complement(1157847) /Source="Nicolas_upshifts" /id="D633" /incds=0 /nref=22 /ntot=152 /MaxReadThrough="1.18091" /MaxDrop="3.57735" /score="3.24324561" /energy="-12.8" /TU="NA" /idTUdmin="U938" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" promotor_-35 1158681..1158685 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-35" promotor_-10 1158702..1158721 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-10" upshifts 1158716 /Source="Nicolas_upshifts" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="upshifts" S_feature 1158717..1158793 /Source="Nicolas_S_feature" /locus_tag="new_1240279_1240355" /HighExp="H2O2, Diami, dia15, Paraq, Oxctl, Heat, G180, Salt, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S419" CDS 1158794..1160638 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 21742892, 24330391; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gated K+/H+ antiporter" /protein_id="NP_389046.1" /db_xref="EnsemblGenomes-Gn:BSU11640" /db_xref="EnsemblGenomes-Tr:CAB13021" /db_xref="GOA:O31615" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13146" /db_xref="UniProtKB/Swiss-Prot:O31615" /translation="MAHTSVASLVVVLIVAFLTPILLHRFKLSIPVVVAEIIMGLIIG KSGLNLVVEGDTWLQTLSMLGFIFLMFLSGLEIDFSSFEKGKKKQFLPNGKEAPNTFA AASVIFVGIFILSLLLSYGFVLAGFIQNAFLMTLIISTISLGVVVPTLKEERIMNSNI GQIILLVAVIADLATMILLAVFSSLYGEDSGNMWLLMILFAAGVVLYFFGRVFKHRSF VQSMSKGTIQIGTRAIFTLIIVLVALSESLGAENILGAFLAGVLVSLLSPNKELVQQL DSFGYGFLIPIFFVMVGVKLDIWTLFQDKTILIMIPLLLLALLVSKIIPVMYLKKWYD NRTIFASGFLLTSTLSLVIAAATIGQQLHVISTNMSGALILVAVIASIFTPICFKKLY KREEQPEEKKTITFIGANQMTLPVTLELPEEEYDVRVVHVYQENAEEKLSESVFAVET ISDYEHETLESLGIFETDILVVATGNEDMNADIALLAKDKGTERVIASVGSPEHEAAL KEQGISIFSILLSTKTLLRALIEAPGVMKLLTNQESSLYQINMENSKYDGVILREFPL TGDVIFVRIFRGVDSIVPHGDTRLKLGDRLIVTGSRGYVTDLKKTLEG*" /label="kefQ CDS" gene 1158794..1160638 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /label="kefQ gene" misc_feature complement(1159121..1159140) /Source="Nicolas_upshift_promotors" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1159145) /Source="Nicolas_upshifts" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1160640..1160647 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-35" promotor_-10 1160661..1160680 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-10" upshifts 1160667 /Source="Nicolas_upshifts" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="upshifts" misc_RNA 1160700..1160808 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswA RNA" gene 1160700..1160808 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /label="tswA gene" downshifts 1160803 /Source="Nicolas_upshifts" /id="D634" /incds=0 /nref=20 /ntot=84 /MaxReadThrough="7.67021" /MaxDrop="5.27759" /score="34.8346124" /energy="-12.5" /TU="U943" /idTUdmin="U941" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS 1160887..1161597 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /EC_number="3.5.99.2" /function="4.11: Thiamine" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 17618314, 18054064, 24311574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 17618314, 18054064, 24311574; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiaminase II" /protein_id="NP_389047.1" /db_xref="EnsemblGenomes-Gn:BSU11650" /db_xref="EnsemblGenomes-Tr:CAB13022" /db_xref="GOA:P25052" /db_xref="InterPro:IPR004305" /db_xref="InterPro:IPR016084" /db_xref="InterPro:IPR027574" /db_xref="PDB:1TO9" /db_xref="PDB:1TYH" /db_xref="PDB:1YAF" /db_xref="PDB:1YAK" /db_xref="PDB:2QCX" /db_xref="SubtiList:BG10791" /db_xref="UniProtKB/Swiss-Prot:P25052" /translation="MKFSEECRSAAAEWWEGSFVHPFVQGIGDGTLPIDRFKYYVLQD SYYLTHFAKVQSFGAAYAKDLYTTGRMASHAQGTYEAEMALHREFAELLEISEEERKA FKPSPTAYSYTSHMYRSVLSGNFAEILAALLPCYWLYYEVGEKLLHCDPGHPIYQKWI GTYGGDWFRQQVEEQINRFDELAENSTEEVRAKMKENFVISSYYEYQFWGMAYRKEGW SDSAIKEVEECGASRHNG*" /label="tenA CDS" gene 1160887..1161597 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /label="tenA gene" CDS 1161572..1162189 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /EC_number="5.3.99.10" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 21534620" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 21534620; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiazole tautomerase" /protein_id="NP_389048.1" /db_xref="EnsemblGenomes-Gn:BSU11660" /db_xref="EnsemblGenomes-Tr:CAB13023" /db_xref="GOA:P25053" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR036206" /db_xref="PDB:1YAD" /db_xref="PDB:3QH2" /db_xref="SubtiList:BG10792" /db_xref="UniProtKB/Swiss-Prot:P25053" /translation="MELHAITDDSKPVEELARIIITIQNEVDFIHIRERSKSAADILK LLDLIFEGGIDKRKLVMNGRVDIALFSTIHRVQLPSGSFSPKQIRARFPHLHIGRSVH SLEEAVQAEKEDADYVLFGHVFETDCKKGLEGRGVSLLSDIKQRISIPVIAIGGMTPD RLRDVKQAGADGIAVMSGIFSSAEPLEAARRYSRKLKEMRYEKAL*" /label="tenI CDS" gene 1161572..1162189 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /label="tenI gene" CDS 1162173..1163282 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /EC_number="1.4.3.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9827558, 11744710, 12627963, 15105420, 19751796, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9827558, 11744710, 12627963, 15105420, 19751796, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="FAD-dependent glycine oxidase" /protein_id="NP_389049.1" /db_xref="EnsemblGenomes-Gn:BSU11670" /db_xref="EnsemblGenomes-Tr:CAB13024" /db_xref="GOA:O31616" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR012727" /db_xref="InterPro:IPR036188" /db_xref="PDB:1NG3" /db_xref="PDB:1NG4" /db_xref="PDB:1RYI" /db_xref="PDB:3IF9" /db_xref="SubtiList:BG13147" /db_xref="UniProtKB/Swiss-Prot:O31616" /translation="MKRHYEAVVIGGGIIGSAIAYYLAKENKNTALFESGTMGGRTTS AAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSE EDVLQLRQMDDLDSVSWYSKEEVLEKEPYASGDIFGASFIQDDVHVEPYFVCKAYVKA AKMLGAEIFEHTPVLHVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNA FLPVKGECLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGLE SVMKKAKTMLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILL APATGALISDLIMNKEVNQDWLHAFRIDRKEAVQI*" /label="thiO CDS" gene 1162173..1163282 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /label="thiO gene" CDS 1163282..1163482 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 14567704, 14757766, 15489164, 22616866, 26443755; Product type c : carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier for synthesis of hydroxyethylthiazole phosphate" /protein_id="NP_389050.1" /db_xref="EnsemblGenomes-Gn:BSU11680" /db_xref="EnsemblGenomes-Tr:CAB13025" /db_xref="GOA:O31617" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010035" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="PDB:1TYG" /db_xref="SubtiList:BG13148" /db_xref="UniProtKB/Swiss-Prot:O31617" /translation="MLQLNGKDVKWKKDTGTIQDLLASYQLENKIVIVERNKEIIGKE RYHEVELCDRDVIEIVHFVGGG*" /label="thiS CDS" gene 1163282..1163482 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /label="thiS gene" CDS 1163479..1164249 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /EC_number="2.8.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14567704, 14757766, 15489164, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14567704, 14757766, 15489164, 22938038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="hydroxyethylthiazole phosphate synthetase (thiamine biosynthesis)" /protein_id="NP_389051.1" /db_xref="EnsemblGenomes-Gn:BSU11690" /db_xref="EnsemblGenomes-Tr:CAB13026" /db_xref="GOA:O31618" /db_xref="InterPro:IPR008867" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033983" /db_xref="PDB:1TYG" /db_xref="PDB:1XM3" /db_xref="SubtiList:BG13149" /db_xref="UniProtKB/Swiss-Prot:O31618" /translation="MSMLTIGGKSFQSRLLLGTGKYPSFDIQKEAVAVSESDILTFAV RRMNIFEASQPNFLEQLDLSKYTLLPNTAGASTAEEAVRIARLAKASGLCDMIKVEVI GCSRSLLPDPVETLKASEQLLEEGFIVLPYTSDDVVLARKLEELGVHAIMPGASPIGS GQGILNPLNLSFIIEQAKVPVIVDAGIGSPKDAAYAMELGADGVLLNTAVSGADDPVK MARAMKLAVEAGRLSYEAGRIPLKQYGTASSPGEGLPV*" /label="thiG CDS" gene 1163479..1164249 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /label="thiG gene" CDS 1164246..1165256 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /EC_number="2.7.7.73" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14567704, 14757766, 15489164, 16388576, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14567704, 14757766, 15489164, 16388576, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate transferase and sulfur transferase (thiamine biosynthesis)" /protein_id="NP_389052.1" /db_xref="EnsemblGenomes-Gn:BSU11700" /db_xref="EnsemblGenomes-Tr:CAB13027" /db_xref="GOA:O31619" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13150" /db_xref="UniProtKB/Swiss-Prot:O31619" /translation="MTGRYSRQELFAPIGPSGQKKLKEARAVIIGAGALGTASAEMLV RAGVGSVKIADRDYVEWSNLQRQQLYTEDDVKKEMPKAAAAERRLRSINSDVDVTGLV MDVTAENIFELIRDASIIVDAADNFETRLIVNDAAVKEGIPFLYGACVGSYGLTFTVV PGSTPCLHCLLDALPIGGATCDTAGIISPAVLQVAVFQVTDALKLLTGEECEPVLRSF DLWKNERSEVRAASLKHDACPSCGTKDFPFLSYENQTKAAVLCGRNTVQIRSSITKEA DLEALAGQLRQAGLEVAANPYLISCRSDDMKMVLFRDGRALIHGTNDIARAKSIYHKW IG*" /label="thiF CDS" gene 1164246..1165256 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /label="thiF gene" CDS 1165275..1166090 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /EC_number="2.7.4.7" /EC_number="2.7.1.49" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14973012, 16952958, 17012797, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14973012, 16952958, 17012797, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine kinase, 4-amino-5-hydroxymethyl-2-methylpyrimidine and 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate kinase" /protein_id="NP_389053.1" /db_xref="EnsemblGenomes-Gn:BSU11710" /db_xref="EnsemblGenomes-Tr:CAB13028" /db_xref="GOA:O31620" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13151" /db_xref="UniProtKB/Swiss-Prot:O31620" /translation="MSIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQ NTLGVHGVHPLTVETLRQQIDAVAEDLRPDAVKTGMLWNADMIEEVARKIDEYGFNRV IVDPVMIAKGGASLLRDESVATLKELLIPRSYAITPNVPEAETLTGMTISSLDDRKKA AEQLVKMGAQHVIIKGGHQPEDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAA LTAQTAKGDSIHQAFEVAANFVREAVENTLGIGSGHGPTNHFAFKRNSLNTSR*" /label="thiD CDS" gene 1165275..1166090 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /label="thiD gene" downshifts 1166064 /Source="Nicolas_upshifts" /id="D635" /incds=0 /nref=128 /ntot=172 /MaxReadThrough="3.33485" /MaxDrop="5.0154" /score="3.40314581" /energy="-14.8" /TU="U943" /idTUdmin="U943" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1166137..1166143 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1166156..1166175 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1166166 /Source="Nicolas_upshifts" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="upshifts" CDS 1166226..1167002 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /EC_number="1.3.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 15105103, 21185310, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 15105103, 21185310, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase" /protein_id="NP_389054.2" /db_xref="EnsemblGenomes-Gn:BSU11720" /db_xref="EnsemblGenomes-Tr:CAB13029" /db_xref="GOA:P54616" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR014358" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIF" /db_xref="PDB:3OIG" /db_xref="SubtiList:BG13152" /db_xref="UniProtKB/Swiss-Prot:P54616" /translation="MNFSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLIFTYAGER LEKSVHELAGTLDRNDSIILPCDVTNDAEIETCFASIKEQVGVIHGIAHCIAFANKEE LVGEYLNTNRDGFLLAHNISSYSLTAVVKAARPMMTEGGSIVTLTYLGGELVMPNYNV MGVAKASLDASVKYLAADLGKENIRVNSISAGPIRTLSAKGISDFNSILKDIEERAPL RRTTTPEEVGDTAAFLFSDMSRGITGENLHVDSGFHITAR*" /label="fabI CDS" gene 1166226..1167002 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /label="fabI gene" downshifts 1166991 /Source="Nicolas_upshifts" /id="D636" /incds=0 /nref=229 /ntot=313 /MaxReadThrough="3.12901" /MaxDrop="6.64182" /score="33.5478109" /energy="-11.8" /TU="U944" /idTUdmin="U944" /TUdmin="-416" /isTUend="FALSE" /label="downshifts" promotor_-35 1167050..1167055 /Source="Nicolas_upshift_promotors" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1167071..1167089 /Source="Nicolas_upshift_promotors" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1167075 /Source="Nicolas_upshifts" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1167087..1167101) /Source="Nicolas_upshift_promotors" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1167087) /Source="Nicolas_upshifts" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1167103..1167786 /gene="cotO" /locus_tag="BSU_11730" /old_locus_tag="BSU11730" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outer coat protein" /protein_id="NP_389055.1" /db_xref="EnsemblGenomes-Gn:BSU11730" /db_xref="EnsemblGenomes-Tr:CAB13030" /db_xref="GOA:O31622" /db_xref="InterPro:IPR025439" /db_xref="SubtiList:BG13153" /db_xref="UniProtKB/Swiss-Prot:O31622" /translation="MKMSNKKRNADKKPLMYIVQPDYAETTRSSMQEIVIKRKADKPA PPKAEEKPAYHEKQQEEAVAQDVLQEDQKPAAEPVSQQTQEAREPENIKSQEEQKAEP QAVEETVEHEPPKAEKKEEPALEARKPEKEPEAVHSADKAEEKAPPARKVKKPMSKMT IHEKIDFLTKLPHNMPRALCLIEANGRTYRGVIVGRRNDSVLLRTTGNGAPTELAIDD ITSLHPLGF*" /label="cotO CDS" gene 1167103..1167786 /gene="cotO" /locus_tag="BSU_11730" /old_locus_tag="BSU11730" /label="cotO gene" promotor_-35 complement(1167109..1167113) /Source="Nicolas_upshift_promotors" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1167781 /Source="Nicolas_upshifts" /id="D637" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="3.37645" /MaxDrop="4.6587" /score="18.0229289" /energy="-13.4" /TU="U945" /idTUdmin="U945" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 1167869 /Source="Nicolas_upshifts" /id="D638" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.44926" /MaxDrop="4.55934" /score="18.0229289" /energy="-13.4" /TU="NA" /idTUdmin="U945" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1167880..1168326) /gene="cotZ" /locus_tag="BSU_11740" /old_locus_tag="BSU11740" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 19933362, 26341943, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 19933362, 26341943, 27320701; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction, crust layer)" /protein_id="NP_389056.1" /db_xref="EnsemblGenomes-Gn:BSU11740" /db_xref="EnsemblGenomes-Tr:CAB13031" /db_xref="GOA:Q08312" /db_xref="InterPro:IPR019593" /db_xref="SubtiList:BG10499" /db_xref="UniProtKB/Swiss-Prot:Q08312" /translation="MSQKTSSCVREAVENIEDLQNAVEEDCPTGCHSKLLSVSHSLGD TVPFAIFTSKSTPLVAFGNVGELDNGPCFNTVFFRVERVHGSCATLSLLIAFDEHKHI LDFTDKDTVCEVFRLEKTNYCIEVDLDCFCAINCLNPRLINRTHHH*" /label="cotZ CDS" gene complement(1167880..1168326) /gene="cotZ" /locus_tag="BSU_11740" /old_locus_tag="BSU11740" /label="cotZ gene" downshifts complement(1167901) /Source="Nicolas_upshifts" /id="D639" /incds=0 /nref=7 /ntot=50 /MaxReadThrough="8.44444" /MaxDrop="7.17581" /score="2.03943557" /energy="-9.3" /TU="U949" /idTUdmin="U950" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1168327..1168453) /Source="Nicolas_S_feature" /locus_tag="new_1249889_1250015_c" /HighExp="S8, S7, S6, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigEF" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S420" CDS complement(1168454..1168942) /gene="cotY" /locus_tag="BSU_11750" /old_locus_tag="BSU11750" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 14766913, 26341943, 26821119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 14766913, 26341943, 26821119; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="outer spore coat protein (crust layer, insolublefraction)" /protein_id="NP_389057.1" /db_xref="EnsemblGenomes-Gn:BSU11750" /db_xref="EnsemblGenomes-Tr:CAB13032" /db_xref="GOA:Q08311" /db_xref="InterPro:IPR019593" /db_xref="SubtiList:BG10498" /db_xref="UniProtKB/Swiss-Prot:Q08311" /translation="MSCGKTHGRHENCVCDAVEKILAEQEAVEEQCPTGCYTNLLNPT IAGKDTIPFLVFDKKGGLFSTFGNVGGFVDDMQCFESIFFRVEKLCDCCATLSILRPV DVKGDTLSVCHPCDPDFFGLEKTDFCIEVDLGCFCAIQCLSPELVDRTSPHKDKKHHH NG*" /label="cotY CDS" gene complement(1168454..1168942) /gene="cotY" /locus_tag="BSU_11750" /old_locus_tag="BSU11750" /label="cotY gene" promotor_-35 1168622..1168628 /Source="Nicolas_upshift_promotors" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1168643..1168662 /Source="Nicolas_upshift_promotors" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1168661 /Source="Nicolas_upshifts" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1168938..1168942 /Source="Nicolas_upshift_promotors" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1168951..1168965 /Source="Nicolas_upshift_promotors" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1168969 /Source="Nicolas_upshifts" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1168979..1168998) /Source="Nicolas_upshift_promotors" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1168996) /Source="Nicolas_upshifts" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1169012..1169021) /Source="Nicolas_upshift_promotors" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1169028..1169046) /Source="Nicolas_upshift_promotors" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1169045) /Source="Nicolas_upshifts" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1169062..1169067) /Source="Nicolas_upshift_promotors" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1169079 /Source="Nicolas_upshifts" /id="D640" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.28604" /MaxDrop="4.18677" /score="-9.76125107" /energy="-10.4" /TU="NA" /idTUdmin="U948" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1169094..1169612) /gene="cotX" /locus_tag="BSU_11760" /old_locus_tag="BSU11760" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 10400595, 10788508, 12031481, 19304857, 26821119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 10400595, 10788508, 12031481, 19304857, 26821119; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction)" /protein_id="NP_389058.1" /db_xref="EnsemblGenomes-Gn:BSU11760" /db_xref="EnsemblGenomes-Tr:CAB13033" /db_xref="GOA:Q08313" /db_xref="InterPro:IPR011428" /db_xref="SubtiList:BG10500" /db_xref="UniProtKB/Swiss-Prot:Q08313" /translation="MESRPYSWVALDPDCDHPLDDKEKDKEKHERKCHCDVCCNGNGF FGNDNAFIDQDLAQANLNKQVSDETIIIRDSCDINVTSTDVQAVTSVVTALNAAVVTA TLTSIADGVIAELVAQDLLQLTANKQVNRQKLLIECSRGVNVTTVDADIATLISTATN TLVAILVITLVL*" /label="cotX CDS" gene complement(1169094..1169612) /gene="cotX" /locus_tag="BSU_11760" /old_locus_tag="BSU11760" /label="cotX gene" downshifts complement(1169118) /Source="Nicolas_upshifts" /id="D641" /incds=0 /nref=76 /ntot=102 /MaxReadThrough="1.79219" /MaxDrop="8.69761" /score="18.5755652" /energy="-10.4" /TU="U952" /idTUdmin="U952" /TUdmin="-29" /isTUend="FALSE" /label="downshifts" downshifts 1169123 /Source="Nicolas_upshifts" /id="D642" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.2156" /MaxDrop="3.69222" /score="-9.76125107" /energy="-10.4" /TU="NA" /idTUdmin="U948" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature complement(1169613..1169710) /Source="Nicolas_S_feature" /locus_tag="new_1251175_1251272_c" /HighExp="S8, S7, S6, BT, B36, G/S, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.748" /TUlongSig="SigK" /TUlongPSig="0.98" /label="S421" CDS complement(1169711..1170028) /gene="cotW" /locus_tag="BSU_11770" /old_locus_tag="BSU11770" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8509331, 19304857, 21665972, 25872412" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509331, 19304857, 21665972, 25872412; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (outemost layer)" /protein_id="NP_389059.1" /db_xref="EnsemblGenomes-Gn:BSU11770" /db_xref="EnsemblGenomes-Tr:CAB13034" /db_xref="GOA:Q08310" /db_xref="SubtiList:BG10497" /db_xref="UniProtKB/Swiss-Prot:Q08310" /translation="MSDNDKFKEELAKLPEVDPMTKMLVQNIFSKHGVTKDKMKKVSD EEKEMLLNLVKDLQAKSQALIENQKKKKEEAAAQEQKNTKPLSRREQLIEQIRQRRKN DNN*" /label="cotW CDS" gene complement(1169711..1170028) /gene="cotW" /locus_tag="BSU_11770" /old_locus_tag="BSU11770" /label="cotW gene" CDS complement(1170069..1170455) /gene="cotV" /locus_tag="BSU_11780" /old_locus_tag="BSU11780" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction)" /protein_id="NP_389060.1" /db_xref="EnsemblGenomes-Gn:BSU11780" /db_xref="EnsemblGenomes-Tr:CAB13035" /db_xref="GOA:Q08309" /db_xref="InterPro:IPR011428" /db_xref="SubtiList:BG10496" /db_xref="UniProtKB/Swiss-Prot:Q08309" /translation="MSFEEKVESLHPAIFEQLSSEFEQQIEVIDCENITIDTSHITAA LSIQAFVTTMIIVATQLVIADEDLADAVASEILILDSSQIKKRTIIKIINSRNIKITL SADEIITFVQILLQVLNSILSELDVL*" /label="cotV CDS" gene complement(1170069..1170455) /gene="cotV" /locus_tag="BSU_11780" /old_locus_tag="BSU11780" /label="cotV gene" promotor_-35 1170451..1170455 /Source="Nicolas_upshift_promotors" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1170463..1170477 /Source="Nicolas_upshift_promotors" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1170465 /Source="Nicolas_upshifts" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1170475..1170494) /Source="Nicolas_upshift_promotors" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1170497) /Source="Nicolas_upshifts" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1170499..1171003) /Source="Nicolas_S_feature" /locus_tag="new_1252061_1252565_c" /HighExp="S8, S6, S7, BT, S5, B36, Pyr, C30, G/S, nit" /AntisenseName="yjcA" /AntisenseCor="0.69838474492609404" /AntisenseRegPval="-39.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S422" promotor_-35 1170552..1170557 /Source="Nicolas_upshift_promotors" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="promotor_-35" promotor_-10 1170573..1170591 /Source="Nicolas_upshift_promotors" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="promotor_-10" upshifts 1170575 /Source="Nicolas_upshifts" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="upshifts" CDS 1170615..1170971 /gene="yjcA" /locus_tag="BSU_11790" /old_locus_tag="BSU11790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein" /protein_id="NP_389061.1" /db_xref="EnsemblGenomes-Gn:BSU11790" /db_xref="EnsemblGenomes-Tr:CAB13036" /db_xref="GOA:O31623" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13154" /db_xref="UniProtKB/Swiss-Prot:O31623" /translation="MVINGLTIVLLSLAVFRLARLLVFDTIMAPLRSLFHEEKEEKDA DGNIETYIVIKGTGVRAFIGELLSCYWCTGVWCAGFLILCQAVIPQAAQWLILLLAIA GLAGIIETLVSKWLQE*" /label="yjcA CDS" gene 1170615..1170971 /gene="yjcA" /locus_tag="BSU_11790" /old_locus_tag="BSU11790" /label="yjcA gene" promotor_-35 1170981..1170990 /Source="Nicolas_upshift_promotors" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="promotor_-35" promotor_-10 complement(1170988..1171007) /Source="Nicolas_upshift_promotors" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="promotor_-10" CDS complement(1170996..1171229) /locus_tag="BSU_11798" /old_locus_tag="BSU11798" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="protein remnant" /db_xref="PSEUDO:SOX90549.1" /translation="MLSETASLKKQKTGVLRFLCQAIEAFSFYFRTRSLSFLSFLIDT MNLYMEIFGKVYDADSFLSPSFPYVIYATLCVF*" /label="protein remnant CDS" gene complement(1170996..1171229) /locus_tag="BSU_11798" /old_locus_tag="BSU11798" /pseudo /label="gene" upshifts complement(1171003) /Source="Nicolas_upshifts" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="upshifts" S_feature 1171004..1171190 /Source="Nicolas_S_feature" /locus_tag="new_1252566_1252752" /HighExp="S8, S6, S7, BT, S5, B36, S4, S3, G/S, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.26970100000000002" /TUshortSig="SigK, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S423" promotor_-10 1171004..1171021 /Source="Nicolas_upshift_promotors" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="promotor_-10" upshifts 1171004 /Source="Nicolas_upshifts" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="upshifts" promotor_-35 complement(1171021..1171030) /Source="Nicolas_upshift_promotors" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="promotor_-35" downshifts complement(1171047) /Source="Nicolas_upshifts" /id="D643" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.12564" /MaxDrop="4.58782" /score="-6.14331629" /energy="-6.8" /TU="NA" /idTUdmin="U954" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" downshifts 1171147 /Source="Nicolas_upshifts" /id="D644" /incds=0 /nref=3 /ntot=32 /MaxReadThrough="5.73879" /MaxDrop="3.6919" /score="33.8150878" /energy="-6.8" /TU="U953,U955" /idTUdmin="U953" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" upshifts complement(1171201) /Source="Nicolas_upshifts" /id="U956" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.284715284715285" /psig="0.032967032967033" /xcortree=768 /SigmaFactorBS="ctcattcacttttatccccccgcttatgatatatgctgagcg agaCCGCCTCGttaaaaaaacaaaaaaccggagttctccggtttctttgccaggctat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1171202..1171211 /Source="Nicolas_upshift_promotors" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1171209..1171216) /Source="Nicolas_upshift_promotors" /id="U956" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.284715284715285" /psig="0.032967032967033" /xcortree=768 /SigmaFactorBS="ctcattcacttttatccccccgcttatgatatatgctgagcg agaCCGCCTCGttaaaaaaacaaaaaaccggagttctccggtttctttgccaggctat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1171225..1171244 /Source="Nicolas_upshift_promotors" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1171235 /Source="Nicolas_upshifts" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="upshifts" CDS 1171253..1171459 /gene="yjzK" /locus_tag="BSU_11799" /old_locus_tag="BSU11799" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097704.1" /db_xref="EnsemblGenomes-Gn:BSU11799" /db_xref="EnsemblGenomes-Tr:CAX52594" /db_xref="UniProtKB/Swiss-Prot:C0H3Y7" /translation="MNEFEKWIEGRYEPHEQKQKEHEDTMGSIRKDLDAFDKAGLEFE DEIEELAEKTEALLKKHQAQYDQS*" /label="yjzK CDS" gene 1171253..1171459 /gene="yjzK" /locus_tag="BSU_11799" /old_locus_tag="BSU11799" /label="yjzK gene" CDS 1171296..1171511 /gene="yjcB" /locus_tag="BSU_11800" /old_locus_tag="BSU11800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein" /protein_id="YP_009513951.1" /translation="MNKSKKSMKTRWAVSEKTWMHLIKPVWNLKMRLKSWLKKRRPYL KNIKLNMINRKSANALCEYPSRSQQLT*" /label="yjcB CDS" gene 1171296..1171511 /gene="yjcB" /locus_tag="BSU_11800" /old_locus_tag="BSU11800" /label="yjcB gene" promotor_-35 1171483..1171492 /Source="Nicolas_upshift_promotors" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1171505..1171524 /Source="Nicolas_upshift_promotors" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1171510 /Source="Nicolas_upshifts" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1171517..1171531) /Source="Nicolas_upshift_promotors" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1171531) /Source="Nicolas_upshifts" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1171541..1171545) /Source="Nicolas_upshift_promotors" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1171541..1171690 /gene="yjcZ" /locus_tag="BSU_11809" /old_locus_tag="BSU11809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523132, 20156992, 21670523; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097705.1" /db_xref="EnsemblGenomes-Gn:BSU11809" /db_xref="EnsemblGenomes-Tr:CAX52595" /db_xref="GOA:C0H3Y8" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y8" /translation="MGFGYGFGGGYGGGCYGGYAGGYGGGYGSTFVLLVVLFILLIIV GASFF*" /label="yjcZ CDS" gene 1171541..1171690 /gene="yjcZ" /locus_tag="BSU_11809" /old_locus_tag="BSU11809" /label="yjcZ gene" downshifts 1171631 /Source="Nicolas_upshifts" /id="D645" /incds=0 /nref=4 /ntot=29 /MaxReadThrough="8.16203" /MaxDrop="4.48861" /score="1.53429015" /energy="-22.4" /TU="U957,U958" /idTUdmin="U955" /TUdmin=110 /isTUend="FALSE" /label="downshifts" S_feature 1171691..1171822 /Source="Nicolas_S_feature" /locus_tag="new_1253253_1253384" /HighExp="S7, BT, S8, B36, S6, G/S, Pyr, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S424" CDS 1171823..1172077 /gene="spoVIF" /locus_tag="BSU_11810" /old_locus_tag="BSU11810" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132, 14702409, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132, 14702409, 20435725; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein needed for heat resistance" /protein_id="NP_389063.2" /db_xref="EnsemblGenomes-Gn:BSU11810" /db_xref="EnsemblGenomes-Tr:CAB13038" /db_xref="GOA:O31625" /db_xref="InterPro:IPR025942" /db_xref="SubtiList:BG13156" /db_xref="UniProtKB/Swiss-Prot:O31625" /translation="MDNQFFKNIEKKTGVKMQDVMNLAGSLQNANFKDENTVRSVINR VAQMANRRVPKELEDKIVESITSGKEKLDFGTISKMMDNK*" /label="spoVIF CDS" gene 1171823..1172077 /gene="spoVIF" /locus_tag="BSU_11810" /old_locus_tag="BSU11810" /label="spoVIF gene" downshifts 1172062 /Source="Nicolas_upshifts" /id="D646" /incds=0 /nref=40 /ntot=79 /MaxReadThrough="5.66609" /MaxDrop="5.8411" /score="7.68851688" /energy="-10.7" /TU="U957,U958" /idTUdmin="U955" /TUdmin=541 /isTUend="FALSE" /label="downshifts" downshifts complement(1172081) /Source="Nicolas_upshifts" /id="D647" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="3.12148" /MaxDrop="4.34051" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=88 /isTUend="FALSE" /label="downshifts" S_feature 1172107..1173207 /Source="Nicolas_S_feature" /locus_tag="new_1253669_1254769" /HighExp="S8, S6, S7, B36, S5, C30, BT, dia15, Diami, H2O2" /AntisenseName="yjcD" /AntisenseCor="-0.210610370451118" /AntisenseRegPval="-3.3" /CDS_PredictionProba="0.18426200000000001" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S425" CDS complement(1172151..1174430) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544244, 16014871, 17114254, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent DNA helicase (sporulationassociated)" /protein_id="NP_389064.3" /db_xref="EnsemblGenomes-Gn:BSU11820" /db_xref="EnsemblGenomes-Tr:CAB13039" /db_xref="GOA:O31626" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG13157" /db_xref="UniProtKB/Swiss-Prot:O31626" /translation="MKCARLNDRIIHLHTYSREHYQFLFEEGIKGHLFCSHCGKPVLL RLNIADPPEFIHRQPGDFPACEEACEPKPSKEGKKEDDQESGVIRLPKGKAIAADPSP AVTEWHRPRSIKPGTPFVPKTIEPDTSLFPSVGLNTDQLKAVTETEGPLLVLAGAGSG KTRVLTARAAHMIEHLGIPPENMLLVTFTTKAVAEMKERMANQYGLQPAKVRRIVTGT FHSLFYKILYHSNSAKWNGEHLLKMEWQREQYIKKALYEEGIDEKESPVDQALQQIGF WKNTYVPNERIPLKDEWEKQVYRLYEHYERQKKEHSQFDFDDMASACYELFIERPDLL EQYQSRFTYILIDEFQDINPVQYKIMQMLASPEQNLCCVGDDDQSIYAFRGSNPSFIL DFQKDYPGAKTIYLTANYRSTHPIVSSADIVVKKNKNRYAKTLEAARDDIQVPVLFYP YDEEEEATMVVSDIKEKIQNGASPEDFAVLYRTNSGGRAIYERLHQSSIPYTADRGVQ SFYSRRIVRQILAYLYASQNEDDTEAIKHLLPALFLKQSALNTLKALSITEDCTMIKA LAKLPDLKPFQLDKIKKIVPFFASLRTMKPVEAITFAEGKMGFSEYLKKRGNEGNKLE KGSDDLRDIKVVAKKFKTIPDFLAHVDHMRAAEKNRTDEHGVQLMTIHRSKGLEFKTV YVLGTVDGSIPHDFSLETARKGDEAALEEERRLLYVAMTRAKQHLYLSCPANRRGKTA NRSRFLYPLLQKARQPLHH*" /label="yjcD CDS" gene complement(1172151..1174430) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /label="yjcD gene" downshifts complement(1172169) /Source="Nicolas_upshifts" /id="D648" /incds=0 /nref=61 /ntot=171 /MaxReadThrough="2.59869" /MaxDrop="4.36061" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1174305..1174479) /Source="Nicolas_S_feature" /locus_tag="new_1255867_1256041_c" /HighExp="G180, G135, G150, H2O2, Paraq, Oxctl, LBGexp, dia15, dia0, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S426" promotor_-35 1174358..1174366 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1174377..1174395 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1174381..1174516 /Source="Nicolas_S_feature" /locus_tag="new_1255943_1256078" /HighExp="S4, S5, S3, S6, S7, S8, M9-stat, T4.0H, T3.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S427" upshifts 1174381 /Source="Nicolas_upshifts" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1174467..1174486) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1174478) /Source="Nicolas_upshifts" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1174494..1174500 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1174502..1174506) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1174515..1174533 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1174518 /Source="Nicolas_upshifts" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1174547..1174801 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11976315, 23155385" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097706.1" /db_xref="EnsemblGenomes-Gn:BSU11839" /db_xref="EnsemblGenomes-Tr:CAX52596" /db_xref="UniProtKB/Swiss-Prot:C0H3Y9" /translation="MIYAGQIQNQQYAQYANRTIGHKQDYAGTEKISYVPFQRVYKEL EKQQENQTAAERKVNEMKRKRSLYKRLREKGMGTYINRYV*" /label="yjzE CDS" gene 1174547..1174801 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /label="yjzE gene" downshifts 1174777 /Source="Nicolas_upshifts" /id="D649" /incds=0 /nref=101 /ntot=248 /MaxReadThrough="3.69482" /MaxDrop="7.80206" /score="5.37568515" /energy="-6.1" /TU="U962" /idTUdmin="U960" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1174867) /Source="Nicolas_upshifts" /id="D650" /incds=0 /nref=78 /ntot=283 /MaxReadThrough="3.21062" /MaxDrop="7.8562" /score="-4.05705392" /energy="-6.1" /TU="U963" /idTUdmin="U963" /TUdmin="-36" /isTUend="FALSE" /label="downshifts" CDS complement(1174874..1175296) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389066.1" /db_xref="EnsemblGenomes-Gn:BSU11840" /db_xref="EnsemblGenomes-Tr:CAB13041" /db_xref="GOA:O31628" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1Q2Y" /db_xref="SubtiList:BG13159" /db_xref="UniProtKB/Swiss-Prot:O31628" /translation="MKAVIAKNEEQLKDAFYVREEVFVKEQNVPAEEEIDELENESEH IVVYDGEKPVGAGRWRMKDGYGKLERICVLKSHRSAGVGGIIMKALEKAAADGGASGF ILNAQTQAVPFYKKHGYRVLSEKEFLDAGIPHLQMMKD*" /label="yjcF CDS" gene complement(1174874..1175296) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /label="yjcF gene" CDS complement(1175300..1175815) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12466548, 16511078, 17012785, 18473364, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA ligase or phosphoesterase" /protein_id="NP_389067.1" /db_xref="EnsemblGenomes-Gn:BSU11850" /db_xref="EnsemblGenomes-Tr:CAB13042" /db_xref="GOA:O31629" /db_xref="InterPro:IPR009097" /db_xref="InterPro:IPR022932" /db_xref="PDB:2D4G" /db_xref="SubtiList:BG13160" /db_xref="UniProtKB/Swiss-Prot:O31629" /translation="MKYGIVLFPSKKLQDLANSYRKRYDPSYSLIPPHLTLRASFECA EEKADQLVSHLRNIAKESHPLVLKMTKYSSFAPVNNVIYIKAEPTEELKTLNEKLYTG VLAGEQEYNFVPHVTVGQNLSDDEHSDVLGQLKMQEVSHEEIVDRFHLLYQLENGSWT VYETFLLGRGE*" /label="yjcG CDS" gene complement(1175300..1175815) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /label="yjcG gene" CDS complement(1175852..1176574) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative stress-related hydrolase" /protein_id="NP_389068.1" /db_xref="EnsemblGenomes-Gn:BSU11860" /db_xref="EnsemblGenomes-Tr:CAB13043" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13161" /db_xref="UniProtKB/Swiss-Prot:O31630" /translation="MAPKNGTVQEKKFFSKELNEEMTLLVYLPSNYSPLYKYHVIIAQ DGHDYFRLGRIGRQVEELLSKREIDRSIIIGVPYKDVKERRNTYHPEGSKFSAYKRFI AHELVPFADDEYPTYQIGYGRTLIGDSLGATVSLMTALDYPNMFGNIIMQSPYVDKHV LEAVKQSDDIKHLSIYHQIGTKETDVHTTDGNILDFTEPNRELKQLLEKKLSDYDFEP FDGDHKWTYWQPLITPALKKML*" /label="yjcH CDS" gene complement(1175852..1176574) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /label="yjcH gene" misc_feature complement(1176613..1176632) /Source="Nicolas_upshift_promotors" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1176634) /Source="Nicolas_upshifts" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1176683..1176690 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1176705..1176724 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1176709 /Source="Nicolas_upshifts" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1176742..1176862 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswA RNA" gene 1176742..1176862 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /label="mswA gene" downshifts 1176867 /Source="Nicolas_upshifts" /id="D651" /incds=0 /nref=8 /ntot=59 /MaxReadThrough="7.71668" /MaxDrop="5.0477" /score="31.1477774" /energy="-15.2" /TU="U964" /idTUdmin="U962" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" CDS 1176930..1178051 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /EC_number="2.5.1.49" /EC_number="2.5.1.48" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-synthase and O-acetylhomoserine thiolyase" /protein_id="NP_389069.1" /db_xref="EnsemblGenomes-Gn:BSU11870" /db_xref="EnsemblGenomes-Tr:CAB13044" /db_xref="GOA:O31631" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13162" /db_xref="UniProtKB/Swiss-Prot:O31631" /translation="MSQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGF DYVRTKNPTRQLVEDAIANLENGARGLAFSSGMAAIQTIMALFKSGDELIVSSDLYGG TYRLFENEWKKYGLTFHYDDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIAR ITKEHGLLLIVDNTFYTPVLQRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLG EEMFQHQNAIGAVLPPFDSWLLMRGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLY PGKGGMLSFRLQKEEWVNPFLKALKTICFAESLGGVESFITYPATQTHMDIPEEIRIA NGVCNRLLRFSVGIEHAEDLKEDLKQALCQVKEGAVSFE*" /label="metI CDS" gene 1176930..1178051 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /label="metI gene" CDS 1178044..1179216 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /EC_number="4.4.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 11948165, 15760717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 11948165, 15760717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-lyase" /protein_id="NP_389070.1" /db_xref="EnsemblGenomes-Gn:BSU11880" /db_xref="EnsemblGenomes-Tr:CAB13045" /db_xref="GOA:O31632" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13163" /db_xref="UniProtKB/Swiss-Prot:O31632" /translation="MSKHNWTLETQLVHNPFKTDGGTGAVSVPIQHASTFHQSSFEEF GAYDYSRSGTPTRTALEETIAALEGGTRGFAFSSGMAAISTAFLLLSQGDHVLVTEDV YGGTFRMVTEVLTRFGIEHTFVDMTDRNEVARSIKPNTKVIYMETPSNPTLGITDIKA VVQLAKENGCLTFLDNTFMTPALQRPLDLGVDIVLHSATKFLSGHSDVLSGLAAVKDE ELGKQLYKLQNAFGAVLGVQDCWLVLRGLKTLQVRLEKASQTAQRLAEFFQKHPAVKR VYYPGLADHPGAETHKSQSTGAGAVLSFELESKEAVKKLVENVSLPVFAVSLGAVESI LSYPATMSHAAMPKEEREKRGITDGLLRLSVGVEHADDLEHDFEQALKEIAPVSVR*" /label="metC CDS" gene 1178044..1179216 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /label="metC gene" downshifts 1179199 /Source="Nicolas_upshifts" /id="D652" /incds=0 /nref=108 /ntot=205 /MaxReadThrough="4.73188" /MaxDrop="5.54268" /score="4.00424187" /energy="-9.2" /TU="U964" /idTUdmin="U964" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" misc_feature 1179233..1179251 /Source="Nicolas_upshift_promotors" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1179243 /Source="Nicolas_upshifts" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="upshifts" S_feature 1179244..1180773 /Source="Nicolas_S_feature" /locus_tag="new_1260806_1262335" /HighExp="MG 5, MG t5, MG 10, BMM, GM 25, MG 15, Glu, GM 15, GM 45, GM 10" /AntisenseName="yjcK" /AntisenseCor="0.123731990206979" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.671, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S428" CDS complement(1179249..1179794) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /EC_number="2.3.1.267" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2828880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal-protein-alanine N-acetyltransferase" /protein_id="NP_389071.1" /db_xref="EnsemblGenomes-Gn:BSU11890" /db_xref="EnsemblGenomes-Tr:CAB13046" /db_xref="GOA:O31633" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13164" /db_xref="UniProtKB/Swiss-Prot:O31633" /translation="MLKGKTIYVRPLEVTDAEENLGLQSENRDFFEQFSMIRADDYYT VEGQRKRITEYQERLEKDEEYHFGIFTASDDRLIGTVSLFQIIRGALQTAFIGYFLDK AHNGKGIMTEAVRLVVDYAFHELKLHRIEAGVMPRNLGSMRVLEKAGFHKEGIARKNV KINGVWEDHQVLAILNPDDEQ*" /label="yjcK CDS" gene complement(1179249..1179794) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /label="yjcK gene" downshifts complement(1179270) /Source="Nicolas_upshifts" /id="D653" /incds=0 /nref=14 /ntot=127 /MaxReadThrough="0.4032" /MaxDrop="4.23858" /score="-7.12102596" /energy="-7.3" /TU="NA" /idTUdmin="U966" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1179864..1181054) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein; possibly aquaporin-related" /protein_id="NP_389072.1" /db_xref="EnsemblGenomes-Gn:BSU11900" /db_xref="EnsemblGenomes-Tr:CAB13047" /db_xref="GOA:O31634" /db_xref="InterPro:IPR008537" /db_xref="SubtiList:BG13165" /db_xref="UniProtKB/Swiss-Prot:O31634" /translation="MHSLISSDDVWVLWGFIAVWAAVSIGLEQRFKWASAVSGAIIAL AGAMVFTNVGVLPVESPVYDTVWSYVVPLAIPLLLFQINVRQIFKESRRLLFIFLISS VGTVLGSILAFFLLKQHIPYLDKIGGMISASYIGGGVNFAAMAAKFETPGEYVSATVV ADNFMMALLFFILISIPALKWFQRHYAMPFEEKVKADGNSGNSAESYWKRKDISLKDI AFNAGAAFALVAVSMKVSGYFKSIFSHPLLTGTLGDQYLVLTSLTVLIIFLFPRFFER LNGSQELGTFLIYLFFVVIGIPADLRLIVTNAPLILLFVFIIAISNLAVSLAAGKLFR VRLEEILLAVNATVGGPTTAAAMAIAKGWRELVAPIMLVGTLGYLIGNYVGTFMGNWF SSFL*" /label="yjcL CDS" gene complement(1179864..1181054) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /label="yjcL gene" promotor_-10 complement(1181080..1181099) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1181084) /Source="Nicolas_upshifts" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1181114..1181121) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1181148..1181155 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1181159 /Source="Nicolas_upshifts" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1181169..1181188 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-10" tRNA 1181227..1181299 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="valine tRNA (GAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val2 tRNA" gene 1181227..1181299 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /label="trnSL-Val2 gene" promotor_-10 complement(1181241..1181258) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1181255) /Source="Nicolas_upshifts" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1181279..1181285) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1181289 /Source="Nicolas_upshifts" /id="D654" /incds=0 /nref=17 /ntot=80 /MaxReadThrough="4.64061" /MaxDrop="5.10012" /score="20.8247903" /energy="-9.1" /TU="U967" /idTUdmin="U965" /TUdmin=550 /isTUend="FALSE" /label="downshifts" S_feature complement(1181314..1182049) /Source="Nicolas_S_feature" /locus_tag="new_1262876_1263611_c" /HighExp="M9-stat, Lbstat, M0t90, Pyr, T0.30H, M40t90, C30, S1, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S429" S_feature 1181334..1182982 /Source="Nicolas_S_feature" /locus_tag="new_1262896_1264544" /HighExp="Cold, C30, G135, G180, G150, Oxctl, Fru, HPh, Glu, UNK1" /AntisenseName="yjcM" /AntisenseCor="0.46809452811910301" /AntisenseRegPval="-15.3" /CDS_PredictionProba="0.27514300000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S430" downshifts complement(1181343) /Source="Nicolas_upshifts" /id="D655" /incds=0 /nref=29 /ntot=192 /MaxReadThrough="1.23936" /MaxDrop="3.57085" /score="-4.98447688" /energy="-7.9" /TU="NA" /idTUdmin="U970" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1182051..1182139) /Source="Nicolas_S_feature" /locus_tag="new_1263613_1263701_c" /HighExp="aero, HPh, M0t45, SMM, dia0, GM 150, Mal, M/G, Mt0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S431" downshifts complement(1182094) /Source="Nicolas_upshifts" /id="D656" /incds=0 /nref=34 /ntot=148 /MaxReadThrough="4.13737" /MaxDrop="4.5557" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-751" /isTUend="FALSE" /label="downshifts" CDS complement(1182140..1183369) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20011599" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389073.1" /db_xref="EnsemblGenomes-Gn:BSU11910" /db_xref="EnsemblGenomes-Tr:CAB13048" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG13166" /db_xref="UniProtKB/Swiss-Prot:O31635" /translation="MKKELLASLVLCLSLSPLVSTNEVFAATTNKETKENVSITNEIG YEKVKDMLEQQKYDFEHNTPLAHPKESKLTDSDEGVLLYSALSKVDKQKFHEFTYDID DVKTSEKNNKLIVEAYITRNFVFGVEKVTTSLGDNIKLEIPKTTSNKQSSQSTNTSNL SFSQVKNSSNQLNVIPLSNSSKQLNVTQLNNSSSTLQYENDEEYSSDVKLDEFLKKYK QEVKNDDKEEVKSEDKPVSMNFNAANSNQLTVTATSVKGYSGYAAMKYAEKYALKPNK NYKYYKDKDCTNFVSQALRAGRMPYFKEWKPYTDAWVNAGAFRSYILKAGGIKMKTVS DTYSNVKLGDVYHYDYHNKIGLRYADGWMDHTAIVTSRANMKLYVSYHSTNRLNVPRE YVTSKEGGKRYVSSIRN*" /label="yjcM CDS" gene complement(1182140..1183369) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /label="yjcM gene" downshifts complement(1182262) /Source="Nicolas_upshifts" /id="D657" /incds=1 /nref=4 /ntot=143 /MaxReadThrough="5.58558" /MaxDrop="3.45178" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-919" /isTUend="FALSE" /label="downshifts" downshifts 1182939 /Source="Nicolas_upshifts" /id="D658" /incds=1 /nref=1 /ntot=48 /MaxReadThrough="3.19343" /MaxDrop="1.98614" /score="26.2462772" /energy="-24.7" /TU="NA" /idTUdmin="U967" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1183370..1183455) /Source="Nicolas_S_feature" /locus_tag="new_1264932_1265017_c" /HighExp="aero, SMM, T-3.40H, MG 150, Lbexp, SMMPr, GM 90, C90, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S432" promotor_-35 1183410..1183417 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1183432..1183451 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1183441..1183460) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1183445 /Source="Nicolas_upshifts" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1183459) /Source="Nicolas_upshifts" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1183473..1183479) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1183495..1183815 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389074.1" /db_xref="EnsemblGenomes-Gn:BSU11920" /db_xref="EnsemblGenomes-Tr:CAB13049" /db_xref="SubtiList:BG13167" /db_xref="UniProtKB/Swiss-Prot:O31636" /translation="MKKKTKIILSLLAALIVILIVLPVLSPVVFTASSEKGAIRHEIY KRGYPYQSYFAVLQKREGDNESGNLYYVNWLDWKDETGQTPHLCYSKKSSDGEYEVSC GTGP*" /label="yjcN CDS" gene 1183495..1183815 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /label="yjcN gene" downshifts 1183825 /Source="Nicolas_upshifts" /id="D659" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="3.73892" /MaxDrop="4.41989" /score="26.2462772" /energy="-24.7" /TU="U969" /idTUdmin="U967" /TUdmin=886 /isTUend="FALSE" /label="downshifts" S_feature 1183870..1183967 /Source="Nicolas_S_feature" /locus_tag="new_1265432_1265529" /HighExp="LoTm, B60, Cold, B36, T3.30H, T3.0H, T4.0H, T2.0H, Sw, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S433" CDS 1183968..1184099 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097707.1" /db_xref="EnsemblGenomes-Gn:BSU11928" /db_xref="EnsemblGenomes-Tr:CAX52597" /db_xref="UniProtKB/Swiss-Prot:C0H3Z0" /translation="MKQSKKKPSQKQHERLDRFWQQMMNTNMQTLRRGKGGAYKRRK* " /label="yjzF CDS" gene 1183968..1184099 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /label="yjzF gene" CDS 1184115..1184288 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097708.1" /db_xref="EnsemblGenomes-Gn:BSU11929" /db_xref="EnsemblGenomes-Tr:CAX52598" /db_xref="UniProtKB/Swiss-Prot:C0H3Z1" /translation="MMKNGFAYKNGKLVNIFCGKEELYNELKAFLVKTFSINVKEVSR PSIYRRTKSKQLE*" /label="yjzG CDS" gene 1184115..1184288 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /label="yjzG gene" CDS 1184325..1184786 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative DNA binding protein; phage island" /protein_id="NP_389075.1" /db_xref="EnsemblGenomes-Gn:BSU11930" /db_xref="EnsemblGenomes-Tr:CAB13050" /db_xref="GOA:O31637" /db_xref="InterPro:IPR013324" /db_xref="SubtiList:BG13168" /db_xref="UniProtKB/Swiss-Prot:O31637" /translation="MTDQMIAWEIEEWIRDYKFMLREIKRLNRVLNKVDFISTKLTAT YGEEAGMPRGSAGVSQAELRQMDRRERRLHKYESIVHYLDNAMEHIEEEKHRIVYDCM MEGMSYTAIANHLDCSRDTIRKIKTAIIGNIVNKVKEANFLQYLNSFKSAV*" /label="yjcO CDS" gene 1184325..1184786 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /label="yjcO gene" promotor_-35 1184757..1184764 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-35" promotor_-10 1184779..1184798 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-10" S_feature 1184787..1185027 /Source="Nicolas_S_feature" /locus_tag="new_1266349_1266589" /HighExp="LoTm, B60, Cold, B36, Diami, S8, dia15, C30, dia5, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12525800000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S434" upshifts 1184787 /Source="Nicolas_upshifts" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="upshifts" promotor_-35 1185000..1185007 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1185021..1185039 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1185029 /Source="Nicolas_upshifts" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1185052..1185555 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein: phage island" /protein_id="NP_389076.1" /db_xref="EnsemblGenomes-Gn:BSU11940" /db_xref="EnsemblGenomes-Tr:CAB13051" /db_xref="GOA:O31638" /db_xref="SubtiList:BG13169" /db_xref="UniProtKB/Swiss-Prot:O31638" /translation="MKKQKNNKKKNIEKRNIEKRNIEEKNNEDLEELENAIYTYHKKE LLAFFLEKTRIGHDKEEYKRFQSLLYKLDIECLEFAISRFSHIDIIHDHSKYVPAFIP LFAAYLTMFFNFYEKHWGALSFAAGTIAAIVWIIAVERKHRNQAISIMKIFEQVKERK VKDRSKD*" /label="yjcP CDS" gene 1185052..1185555 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /label="yjcP gene" CDS 1185567..1185851 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389077.1" /db_xref="EnsemblGenomes-Gn:BSU11950" /db_xref="EnsemblGenomes-Tr:CAB13052" /db_xref="InterPro:IPR018597" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HGC" /db_xref="SubtiList:BG13170" /db_xref="UniProtKB/Swiss-Prot:O31639" /translation="MNKDKLRYAILKEIFEGNTPLSENDIGVTEDQFDDAVNFLKREG YIIGVHYSDDRPHLYKLGPELTEKGENYLKENGTWSKAYKTIKEIKDWIK*" /label="yjcQ CDS" gene 1185567..1185851 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /label="yjcQ gene" downshifts 1185821 /Source="Nicolas_upshifts" /id="D660" /incds=0 /nref=215 /ntot=271 /MaxReadThrough="1.63272" /MaxDrop="7.26386" /score="22.0381158" /energy="-7.2" /TU="NA" /idTUdmin="U969" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1185853) /Source="Nicolas_upshifts" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1185864..1185867) /Source="Nicolas_upshift_promotors" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1186012..1186539 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7489895, 7704261; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage-related nucleic acid binding terminase small subunit; phage island" /protein_id="NP_389078.1" /db_xref="EnsemblGenomes-Gn:BSU11960" /db_xref="EnsemblGenomes-Tr:CAB13053" /db_xref="GOA:O31640" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010332" /db_xref="SubtiList:BG13171" /db_xref="UniProtKB/Swiss-Prot:O31640" /translation="MAEKHIQAYKDYVKGMKYKDLAEKYGVSVNTIKSWKQRHGWERK KGAPIEKSVHTKKGGQPGNKNALGNNGGAPQKNQNAVTHGFFSKFLPEETLEIMEEIQ ERSPADMIWDQIQIQYAAILRAQKIMFVSDKEEMIKELKKKRSLISEVSEIEDGLVIS FSTWFRYRLYSETNT*" /label="yjcR CDS" gene 1186012..1186539 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /label="yjcR gene" promotor_-35 1186686..1186691 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1186704..1186723 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1186707 /Source="Nicolas_upshifts" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="upshifts" CDS 1186713..1187030 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389079.1" /db_xref="EnsemblGenomes-Gn:BSU11970" /db_xref="EnsemblGenomes-Tr:CAB13054" /db_xref="GOA:O31641" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:1Q8B" /db_xref="SubtiList:BG13172" /db_xref="UniProtKB/Swiss-Prot:O31641" /translation="MKSHKMMGGGISMHYITACLKIISDKDLNEIMKEFKKLEEETNK EEGCITFHAYPLEPSERKIMLWEIWENEEAVKIHFTKKHTIDVQKQELTEVEWLMKSN VND*" /label="yjcS CDS" gene 1186713..1187030 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /label="yjcS gene" S_feature 1187031..1187266 /Source="Nicolas_S_feature" /locus_tag="new_1268593_1268828" /HighExp="dia5, H2O2, dia15, dia0, Lbexp, Lbtran, C90, Oxctl, S1, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S435" CDS 1187267..1188022 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2243795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-carrier protein oxidoreductase; phage island" /protein_id="NP_389080.1" /db_xref="EnsemblGenomes-Gn:BSU11980" /db_xref="EnsemblGenomes-Tr:CAB13055" /db_xref="GOA:O31642" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13173" /db_xref="UniProtKB/Swiss-Prot:O31642" /translation="MSHSQEKIALITGASSQGDIGTAICRKLASQGIHIFFTHWNSDT AWIEEFQQEILRMGVRCEAMKIDLSDAHAAFTIHEKISDKLGYPSILINNAAHSASDN YVSLDAKSLDEHYAVNMRSNFLLCVEFARRFKKSNLISGRIINMTSGQDLGPLPGELA YAATKGAISAFTRSLSQELAPLGITVNAVNPGPTDSTWMTDEIRNFLSPKFPMGRIGT PDDAARMIAFLASDEAEWITGQIIHSEGGFIRG*" /label="yjdA CDS" gene 1187267..1188022 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /label="yjdA gene" S_feature 1188023..1188110 /Source="Nicolas_S_feature" /locus_tag="new_1269585_1269672" /HighExp="C90, S1, dia0, dia5, Mt0, Lbexp, Gly, H2O2, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S436" downshifts 1188067 /Source="Nicolas_upshifts" /id="D661" /incds=0 /nref=89 /ntot=238 /MaxReadThrough="2.66489" /MaxDrop="5.39812" /score="-0.84766737" /energy="-14.2" /TU="NA" /idTUdmin="U974" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(1188110..1188170) /Source="Nicolas_S_feature" /locus_tag="new_1269672_1269732_c" /HighExp="Lbstat, BI, BT, nit, S2, ferm, B60, B36, M0t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S437" downshifts complement(1188141) /Source="Nicolas_upshifts" /id="D662" /incds=0 /nref=80 /ntot=134 /MaxReadThrough="1.9707" /MaxDrop="7.43843" /score="-5.56180712" /energy="-14.2" /TU="NA" /idTUdmin="U975" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1188171..1188518) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported protein; phage island" /protein_id="NP_389081.1" /db_xref="EnsemblGenomes-Gn:BSU11990" /db_xref="EnsemblGenomes-Tr:CAB13056" /db_xref="InterPro:IPR003343" /db_xref="InterPro:IPR008964" /db_xref="SubtiList:BG13174" /db_xref="UniProtKB/Swiss-Prot:O31643" /translation="MNFKKTVVSALSISALALSVSGVASAHEINSTPTEVKNISISPT HVIKIQDYNLPLKVGETYSVKNNSATRYWTDNQKVAEVDQNGLVTAKSKGKATITLFK GTAVFGKVYVTVY*" /label="yjdB CDS" gene complement(1188171..1188518) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /label="yjdB gene" promotor_-10 complement(1188550..1188568) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1188563) /Source="Nicolas_upshifts" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1188565..1189021) /Source="Nicolas_S_feature" /locus_tag="new_1270127_1270583_c" /HighExp="T1.30H, T2.0H, T2.30H, T3.0H, M9-stat, T1.0H, Lbstat, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S438" promotor_-35 complement(1188579..1188587) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1188981..1188999 /Source="Nicolas_upshift_promotors" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1188993 /Source="Nicolas_upshifts" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="upshifts" promotor_-10 complement(1188999..1189018) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1189021) /Source="Nicolas_upshifts" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1189032..1189039) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1189069..1191015 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10438772, 10960106, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438772, 10960106, 23551403; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional DNA-binding activator" /protein_id="NP_389082.2" /db_xref="EnsemblGenomes-Gn:BSU12000" /db_xref="EnsemblGenomes-Tr:CAB13057" /db_xref="GOA:O31644" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG13175" /db_xref="UniProtKB/Swiss-Prot:O31644" /translation="MEYINTRQKEILYLLLSEPDDYLVVQDFADRVQCSEKTIRNDLK VIEDYLNEHSHAQLIRKPGLGVYLHIEEQERTWLSQQLHTEHFSSRQRSDKERMLHIA YDLLMNPKPVSAKDIAARHFVNRSSIKKDLYAVEEWLKRFDLTLVSRQRLGLKVEGNE RNKRKALARISDLIHNTAFTSQFIKSKFLHYEVDFVTKEIKSLQKKHSLYFTDETFES LLLHTLLMVRRIKMKQPISLSPKEMAAVKKKKEYQWTFACLQRLEPVFAIRFPEEEAV YLTLHILGGKVRYPLQTEENLENAVLPKVVGHLINRVSELKMMDFHKDQDLINGLNIH LNTVLQRLSYDLSVANPMLNDIKKMYPYLFHLIIDVLEDINQTFDLHIPEEEAAYLTL HFQAAIERMQGSSETHKKAVIVCHMGIGMSQLLRTKIERKYHQIAVMACIAKADLKDY IKKHEDIDLVISTIALENITVPHIVVSPLLEPGEEKKLSAFIRQLGESHRQKQKTFQM LNNTTPFLVFLQQEAEHRYKLIEQLATALFEKGYVDKDYAVHAVMREKMSATNIGSGI AIPHANAKFIKQSAIAIATLKEPLEWGNEKVSLVFMLAVKHEDQTMTKQLFSELSYLS EQPAFVQKLTKETNVMTFLSHLDY*" /label="manR CDS" gene 1189069..1191015 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /label="manR gene" downshifts 1190991 /Source="Nicolas_upshifts" /id="D663" /incds=0 /nref=3 /ntot=35 /MaxReadThrough="4.64475" /MaxDrop="3.79938" /score="28.4199725" /energy="-9.1" /TU="U976" /idTUdmin="U976" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" SCAR 1191045..1191046 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs02" S_feature <1191046..1191144 /Source="Nicolas_S_feature" /locus_tag="new_1275640_1275738" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, H2O2, dia5, Fru, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15168699999999999" /TUshortSig="SigA" /TUshortPSig="0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S439" promotor_-35 1191119..1191125 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1191140..1191159 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1191146..1191214 /Source="Nicolas_S_feature" /locus_tag="new_1275740_1275808" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, dia5, Fru, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S440" upshifts 1191146 /Source="Nicolas_upshifts" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="upshifts" CDS 1191215..1191697 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20139185" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389085.1" /db_xref="EnsemblGenomes-Gn:BSU12030" /db_xref="EnsemblGenomes-Tr:CAB13060" /db_xref="InterPro:IPR016787" /db_xref="SubtiList:BG13178" /db_xref="UniProtKB/Swiss-Prot:O31647" /translation="MSVTFPSSGCPSFFNIFYEEGIVMKLTIYYDGQFWVGVVEVVDN GKLRAFRHLFGKEPRDSEVLEFVHNQLLNMMAQAEQEGVRLQGRRQKKINPKRLQRQV SKELKNAGVTSKAQEAIKLELEARKQKKKQIMKEQREHVKEQRYMLKKQKAKKKHRGK *" /label="yjdF CDS" gene 1191215..1191697 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /label="yjdF gene" downshifts 1191677 /Source="Nicolas_upshifts" /id="D664" /incds=0 /nref=220 /ntot=267 /MaxReadThrough="5.32805" /MaxDrop="7.35641" /score="7.68574519" /energy="-10.2" /TU="U978" /idTUdmin="U980" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1191743..1192249) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389086.1" /db_xref="EnsemblGenomes-Gn:BSU12040" /db_xref="EnsemblGenomes-Tr:CAB13061" /db_xref="GOA:O31648" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13179" /db_xref="UniProtKB/Swiss-Prot:O31648" /translation="MVLLETNRLRLQTIDIPLLDAASKQDHQAIKELGYETNGEWPNS DFFEAIPYFREILVKNNGTKGFDSWIIVKKDNYEIVGGTGFLGDPDENGMIEIGFATN KSHRRKGYCVEAAQKLINWALSRETVSRITARCEHDNLGSQKTLEKLGFILNHKSAEY KHWIYVTK*" /label="yjdG CDS" gene complement(1191743..1192249) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /label="yjdG gene" downshifts complement(1191767) /Source="Nicolas_upshifts" /id="D665" /incds=0 /nref=13 /ntot=154 /MaxReadThrough="2.51872" /MaxDrop="4.09551" /score="15.8830125" /energy="-9.9" /TU="NA" /idTUdmin="U984" /TUdmin=7 /isTUend="TRUE" /label="downshifts" misc_feature complement(1192274..1192293) /Source="Nicolas_upshift_promotors" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1192280) /Source="Nicolas_upshifts" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1192282..1192467) /Source="Nicolas_S_feature" /locus_tag="new_1276876_1277061_c" /HighExp="S5, S4, S7, S6, S8, B36, LoTm, S3, B60, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.289238" /TUshortSig="SigEF, SigWXY" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S441" CDS complement(1192468..1192863) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389087.2" /db_xref="EnsemblGenomes-Gn:BSU12050" /db_xref="EnsemblGenomes-Tr:CAB13062" /db_xref="SubtiList:BG13180" /db_xref="UniProtKB/Swiss-Prot:O31649" /translation="MYHYFYGPALIPYFSHTHNPQRSPDFSERQRRREITLTVDGFVP PSSTEDLGDGFYSYAWTNQQVINPGEYLVCHLEGRDINVINGGFTPRDTAPLYAVASF PRRRNQWVIIIHNPVQTQRAISLYLIAKR*" /label="yjdH CDS" gene complement(1192468..1192863) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /label="yjdH gene" promotor_-10 complement(1192886..1192904) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1192899) /Source="Nicolas_upshifts" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1192901..1193601) /Source="Nicolas_S_feature" /locus_tag="new_1277495_1278195_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, S0, T2.0H, Salt, T2.30H, T-1.10H" /AntisenseName="yjdI" /AntisenseCor="-0.383915151906285" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S442" promotor_-35 complement(1192919..1192924) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1193007..1193014 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1193028..1193047 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1193039 /Source="Nicolas_upshifts" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="upshifts" CDS 1193092..1193571 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22128149; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cys-tRNApro deacetylase; tRNA editing" /protein_id="NP_389088.1" /db_xref="EnsemblGenomes-Gn:BSU12060" /db_xref="EnsemblGenomes-Tr:CAB13063" /db_xref="GOA:O31650" /db_xref="InterPro:IPR004369" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG13181" /db_xref="UniProtKB/Swiss-Prot:O31650" /translation="MAKKMAKTNAVRLIEQQNISYEVLGYKTDGQPVDGISVAEKIGY SLKYVYKTLVAAAGTNHYYVFVVPVAEELDVKKAAKVTGEKKIEMIAMKELLAVTGYL RGGCSPIGMKKLFPTYIDASAETLDFIIVSAGKIGMQLKLAPQDLARSCDAAFAEIV* " /label="trnE CDS" gene 1193092..1193571 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /label="trnE gene" downshifts 1193570 /Source="Nicolas_upshifts" /id="D666" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="2.68858" /MaxDrop="3.19616" /score="-5.52314972" /energy="-12.5" /TU="NA" /idTUdmin="U978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1193611..1193805) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097709.1" /db_xref="EnsemblGenomes-Gn:BSU12069" /db_xref="EnsemblGenomes-Tr:CAX52599" /db_xref="InterPro:IPR025234" /db_xref="UniProtKB/Swiss-Prot:C0H3Z2" /translation="MKEYEFVRVELSTMRRRPKEDYQQIIHDYAKRGWRFVQIFAPSI DGYGAAAYFEIIFERDAEKA*" /label="yjzH CDS" gene complement(1193611..1193805) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /label="yjzH gene" downshifts complement(1193646) /Source="Nicolas_upshifts" /id="D667" /incds=0 /nref=6 /ntot=144 /MaxReadThrough="7.83072" /MaxDrop="2.95935" /score="-6.07514027" /energy="-7" /TU="U984" /idTUdmin="U987" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1193819..1193834) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1193835) /Source="Nicolas_upshifts" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1193846..1193855) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1193971..1194300) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389089.1" /db_xref="EnsemblGenomes-Gn:BSU12070" /db_xref="EnsemblGenomes-Tr:CAB13064" /db_xref="GOA:O31651" /db_xref="InterPro:IPR016508" /db_xref="InterPro:IPR025440" /db_xref="SubtiList:BG13182" /db_xref="UniProtKB/Swiss-Prot:O31651" /translation="MKGIFLVVQLGFSIMVFLFLAAVNWYQGSELVSDRFDWNYTAKL SKLLNGIDAVSSPKQISQLDFFIYSAKHYPVMSALMIISFLYVLAALFLLIYSVKCNK QEIHLDC*" /label="yjdJ CDS" gene complement(1193971..1194300) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /label="yjdJ gene" promotor_-10 complement(1194337..1194356) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1194350) /Source="Nicolas_upshifts" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1194352..1194919) /Source="Nicolas_S_feature" /locus_tag="new_1278946_1279513_c" /HighExp="S8, S6, nit, S7, ferm, S2, S5, M9-tran, M/G, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S443" promotor_-35 complement(1194371..1194376) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1194404..1194408 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1194424..1194443 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1194428..1194929 /Source="Nicolas_S_feature" /locus_tag="new_1279022_1279523" /HighExp="LBGstat, C30, HPh, Oxctl, dia15, Paraq, T0.30H, C90, LBGtran, LPh" /AntisenseName="ctaO" /AntisenseCor="-0.43946575370083102" /AntisenseRegPval="-13.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S444" upshifts 1194428 /Source="Nicolas_upshifts" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1194920..1195909) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10675592, 15491161, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10675592, 15491161, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor protoheme IX farnesyltransferase 1 (heme Osynthase)" /protein_id="NP_389090.2" /db_xref="EnsemblGenomes-Gn:BSU12080" /db_xref="EnsemblGenomes-Tr:CAB13065" /db_xref="GOA:O31652" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG13183" /db_xref="UniProtKB/Swiss-Prot:O31652" /translation="MQFWGRRLFLENTRDSAAISETKYIKASNRVTIYDFIKLAKPGI IISNSIAAFGGFWIAFASAEKTLTGLAFLMTMVTAMLGTAFVMASGTVYNNYFDRHMD AKMARTRSRASVTGKMPPAMILTYGSVLGIAGLAMLYSLNPLTAFLGLAAFIFYAIIY TVWVKRTSVWSTFVGSFPGAAPPLMGYCAVTGDFSMTAVLLYTIMFLWQPPHFWAIGI RRKEEYRAAGVPLLPVVKGNHVTKIKMMQYIAVLVPVTLLFPFSLGTGHISPFYFLAA LVLGGIWIKKSIKGFKTDDDVKWAKDMFVYSLIYFCLLFFIMMIDSFMMFLIR*" /label="ctaO CDS" gene complement(1194920..1195909) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /label="ctaO gene" promotor_-10 complement(1195910..1195929) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-10" upshifts complement(1195913) /Source="Nicolas_upshifts" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="upshifts" promotor_-35 complement(1195943..1195948) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-35" CDS complement(1196032..1196280) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1391045, 1917883, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1391045, 1917883, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner coat)" /protein_id="NP_389091.2" /db_xref="EnsemblGenomes-Gn:BSU12090" /db_xref="EnsemblGenomes-Tr:CAB13066" /db_xref="GOA:P11863" /db_xref="SubtiList:BG10495" /db_xref="UniProtKB/Swiss-Prot:P11863" /translation="MDYPLNEQSFEQITPYDERQPYYYPRPRPPFYPPYYYPRPYYPF YPFYPRPPYYYPRPRPPYYPWYGYGGGYGGGYGGGYGY*" /label="cotT CDS" gene complement(1196032..1196280) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /label="cotT gene" downshifts complement(1196042) /Source="Nicolas_upshifts" /id="D668" /incds=0 /nref=37 /ntot=82 /MaxReadThrough="5.73194" /MaxDrop="6.23577" /score="25.0951218" /energy="-8.4" /TU="U989" /idTUdmin="U990" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1196276..1196280 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1196289..1196303 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1196298 /Source="Nicolas_upshifts" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1196305..1196324) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1196314) /Source="Nicolas_upshifts" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1196338..1196347) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1196395..1196402 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1196409..1196428) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1196416..1196435 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1196418) /Source="Nicolas_upshifts" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="upshifts" upshifts 1196429 /Source="Nicolas_upshifts" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1196430..1196533 /Source="Nicolas_S_feature" /locus_tag="new_1281024_1281127" /HighExp="Heat, T0.30H, T1.0H, ferm, Diami, dia5, T1.30H, M9-stat, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S445" promotor_-35 complement(1196442..1196449) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1196534..1197937 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 17878218, 22277649" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 17878218, 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid deacetylase" /protein_id="NP_389092.1" /db_xref="EnsemblGenomes-Gn:BSU12100" /db_xref="EnsemblGenomes-Tr:CAB13067" /db_xref="GOA:O34798" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR017219" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="SubtiList:BG13184" /db_xref="UniProtKB/Swiss-Prot:O34798" /translation="MLAKRIKWFHVLIAVVCVVGLIGFFHNHSLKKETVMNKVRTDSQ YGNVEIATLVNDGKTFNYAVNYPVFKNEKMDSALKRFAEKEVRQFQKETKDVDQEHTT KRNELNVDYKIVHYAKQTVAIVFNEYKYIGGAHGQTVKKTFNYDFSKQAFLSIDDIFK EDADYLHKLSLIAYHELKKNKDIAADDALLKEGTAPKKENFSRFAIKEDYIELYFDTY QVAAGYLGEQSIAIKKSLLKDILKEQYIDKAKNKNKIKEQKPKHEVISLPKEETVDPN QKVIALTFDDGPNPATTNQILDSLKKYKGHATFFVLGSRVQYYPETLIRMLKEGNEVG NHSWSHPLLTRLSVKEALKQINDTQDIIEKISGYRPTLVRPPYGGINDELRSQMKMDV ALWDVDPEDWKDRNKKTIVDRVMNQAGDGRTILIHDIYRTSADAADEIIKKLTDQGYQ LVTVSQLEEVKKQREAK*" /label="pdaC CDS" gene 1196534..1197937 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /label="pdaC gene" downshifts 1197926 /Source="Nicolas_upshifts" /id="D669" /incds=0 /nref=173 /ntot=238 /MaxReadThrough="1.38483" /MaxDrop="6.60322" /score="39.935002" /energy="-13.8" /TU="NA" /idTUdmin="U991" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1197977..1198450) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389093.1" /db_xref="EnsemblGenomes-Gn:BSU12110" /db_xref="EnsemblGenomes-Tr:CAB13068" /db_xref="InterPro:IPR021224" /db_xref="SubtiList:BG13185" /db_xref="UniProtKB/Swiss-Prot:O34554" /translation="MKRLFMKASLVLFAVVFVFAVKGAPAKAETHAYDGKSPYYNDCA SSGSTKKSSNLVNASNQVIGVVELKFSSTCKTAWAKITMNNTLTSGYEANAEITRNTD GKRYNCDSAGGNGKAVAGQKSCYTPMVYDLDPRTSYAFGKYSGPNLNVWATTGSY*" /label="yjfA CDS" gene complement(1197977..1198450) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /label="yjfA gene" downshifts complement(1197981) /Source="Nicolas_upshifts" /id="D670" /incds=0 /nref=33 /ntot=176 /MaxReadThrough="2.25434" /MaxDrop="5.38548" /score="20.5383759" /energy="-13.8" /TU="NA" /idTUdmin="U992" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1198472..1198490) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1198490) /Source="Nicolas_upshifts" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1198505..1198510) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1198575..1198742) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389094.1" /db_xref="EnsemblGenomes-Gn:BSU12120" /db_xref="EnsemblGenomes-Tr:CAB13069" /db_xref="InterPro:IPR025906" /db_xref="SubtiList:BG13186" /db_xref="UniProtKB/Swiss-Prot:O34438" /translation="MDIPALSVAMHQASLAQNVNIALTKKRLDTAQQNADQTLKMIQH PTLGQTIDVKA*" /label="yjfB CDS" gene complement(1198575..1198742) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /label="yjfB gene" downshifts complement(1198578) /Source="Nicolas_upshifts" /id="D671" /incds=0 /nref=109 /ntot=232 /MaxReadThrough="3.53249" /MaxDrop="4.93218" /score="-9.08395816" /energy="-13.9" /TU="U993" /idTUdmin="U993" /TUdmin="-576" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1198754..1198772) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1198763) /Source="Nicolas_upshifts" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1198785..1198792) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1198869..1199768 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389095.2" /db_xref="EnsemblGenomes-Gn:BSU12130" /db_xref="EnsemblGenomes-Tr:CAB13070" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13187" /db_xref="UniProtKB/Swiss-Prot:O34458" /translation="MNLVMEKTFEQYEKLFSMEEQKREDVFRYTMMRPFEKMWTAIQV PLKAKEPNGYDVIMAAKMLGYLDVRDAESGQKALQILKESHVSETAESALRQCIFFAE REQLRVNAKEIKFGLYIADPNKLQLQKGYCGFGGIPGFIHVWINPNSYNLPRIPSIIA HEFHHNVRFSYIDFHHGSVSVGDYLVIEGLAESFARELFGTERLGPWVTRFDHEDLQY SIDVINEVLDVKGFSEVSRYMFGDPIANDQGFKPAGLSAFAGYAVGYHAVQSFMNQHH ITISEATRLDAKTIISQCGLFST*" /label="yjfC CDS" gene 1198869..1199768 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /label="yjfC gene" CDS complement(1199777..1200175) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_389096.1" /db_xref="EnsemblGenomes-Gn:BSU12140" /db_xref="EnsemblGenomes-Tr:CAB13071" /db_xref="GOA:O35027" /db_xref="InterPro:IPR021257" /db_xref="SubtiList:BG13188" /db_xref="UniProtKB/Swiss-Prot:O35027" /translation="MKRNRWIYAVFTILIIGLGLGSRAFSSVLPDTLNTYLGDSLWAA MIFTGCGFLFRKLKTMITGIISLSFCFVIEFSQLYHAEWIDQIRDTSLGGLVLGYGFL WSDIEAYTIGIAACAAIELLVLGIKKRRCM*" /label="yjgA CDS" gene complement(1199777..1200175) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /label="yjgA gene" downshifts complement(1199807) /Source="Nicolas_upshifts" /id="D672" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.86089" /MaxDrop="2.52307" /score="23.8106216" /energy="-10.1" /TU="U994,U995" /idTUdmin="U995" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1200204..1200223) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1200223) /Source="Nicolas_upshifts" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1200238..1200245) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1200276..1200851) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1580552" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389097.1" /db_xref="EnsemblGenomes-Gn:BSU12150" /db_xref="EnsemblGenomes-Tr:CAB13072" /db_xref="InterPro:IPR025453" /db_xref="PDB:4YGT" /db_xref="SubtiList:BG13189" /db_xref="UniProtKB/Swiss-Prot:O34960" /translation="MKKTMSAITAAAAVTSCFTGFGAASFSAPAKAAAQTNTLSENTN QSAAELVKNLYNTAYKGEMPQQAQGLTINKSTKGDVHAAFGEPERPVGGDNRFDLYHW NMGQPGYGFSYHKDMTISEIRYFGTGVERQLNLGGVTPEVLQKQLGPVNRVLTVPFTD EIDYVYDTGRYELHFVIGTDQTADHVNLKAK*" /label="yjgB CDS" gene complement(1200276..1200851) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /label="yjgB gene" downshifts complement(1200291) /Source="Nicolas_upshifts" /id="D673" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.38565" /MaxDrop="3.9021" /score="23.8106216" /energy="-10.1" /TU="U995" /idTUdmin="U995" /TUdmin="-727" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1200870..1200888) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1200885) /Source="Nicolas_upshifts" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1200902..1200908) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1200926..1200932 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1200947..1200965 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1200948 /Source="Nicolas_upshifts" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="upshifts" CDS 1200997..1203954 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /EC_number="1.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdoenzyme; putative formate dehydrogenase" /protein_id="NP_389098.1" /db_xref="EnsemblGenomes-Gn:BSU12160" /db_xref="EnsemblGenomes-Tr:CAB13073" /db_xref="GOA:O34720" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG13190" /db_xref="UniProtKB/Swiss-Prot:O34720" /translation="MAGKKTITINGVEMEASEEQTVLQLLNNSSIEVPQVCYHPSLGP IETCDTCIVSINGELKRSCSAELKDGDVIDTLSPDVKKAQVIGMDKILYNHELYCTVC DYNNGGCEIHNTVKEMKINHQSIPFDHKPYHKDESHPFYRYDPDQCILCGRCVEACQD VQVTETLTIDWERKRPRVIWDNDVPINESSCVSCGHCSTVCPCNAMMEKGMEGEAGYL TGINNETLRPMIEITKGVETGYGSILAISDMESAMRDERIKKTKTVCTYCGVGCSFDV WTKGRDILKVEPQEEAPANGISTCVKGKFGWDFVNSEERLTKPLIREGDHFREAEWEE ALLLIASKFTELKEAFGPDSLAFITSSKCTNEESYLMQKLARGVIGTNNVDNCSRYCQ SPATAGLFRTVGYGGDSGSITDIAQADLVLIIGSNTSESHPVLSTRIKRAHKLRGQKV IVADIRKHEMAERSDLFVQPRAGSDIVWLNAIAKYLIENGKADERFLRERVNGRDEYV KSLAPYTLEYAEEKTGIDQETLIQMAEMIGQADSVCALWAMGVTQHIGGSDTSTAISN LLLVTGNYGKPGAGSYPLRGHNNVQGASDFGSMPDRLPGYEKVTDEQVRQKYERVWGV PLPKEPGMTNHEMIEKIHSGQLKAMYVKGEEMGLVDSNINHVHAAYEKLDFFVVQDIF LSRTAEFADVVLPASPSLEKEGTFTNTERRIQRLYQVFEPLGESKPDWQIIMEVANKL GAGWLYEHPADIMEEAAKLSPIYAGVTYERLEGYNSLQWPVNADGKDSPLLFTERFPF PDGKAILYPVQWTEPKEFGEEYDIHVNNGRLLEHFHEGNLTYKSKGISEKTPEVFLEI SPELAAERGIQDGTLVRLTSPFGNVKVKCLITDRVKGKEVYLPMNDSGEAAINLLTGS HADKDTDTPAYKETSAKMEILKHDGISPLPKINHRNGNPQPQIGVQVHKKWARKDYIF PGDAVKRGMGHNG*" /label="yjgC CDS" gene 1200997..1203954 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /label="yjgC gene" CDS 1203947..1204507 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389099.1" /db_xref="EnsemblGenomes-Gn:BSU12170" /db_xref="EnsemblGenomes-Tr:CAB13074" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13191" /db_xref="UniProtKB/Swiss-Prot:O34681" /translation="MAKAIKRIQKIEVTEEDQRKRDLREIEDALIDHKEAILETLHML GHMNERGVLPLLRGLFGQGDKVLDILVKKADTEETANTLKNLLLLFGTLGMLDVKQLE PLILKVNAGVASAVEQKNSEEKTGYFDIIRSLKDPEINKSITLLFSFLKGMGQDTKEL ERTTQPPEHQKHHQEPREKRGMNKRD*" /label="yjgD CDS" gene 1203947..1204507 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /label="yjgD gene" downshifts 1204500 /Source="Nicolas_upshifts" /id="D674" /incds=0 /nref=18 /ntot=84 /MaxReadThrough="5.25706" /MaxDrop="6.46184" /score="20.7921843" /energy="-15" /TU="U996" /idTUdmin="U996" /TUdmin="-819" /isTUend="FALSE" /label="downshifts" S_feature 1204545..1204663 /Source="Nicolas_S_feature" /locus_tag="new_1289139_1289257" /HighExp="Etha, Salt, Heat, S8, M9-stat, S7, LPhT, G135, C30, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S446" promotor_-35 1204641..1204644 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1204660..1204679 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1204665 /Source="Nicolas_upshifts" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="upshifts" CDS 1204704..1205345 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389100.1" /db_xref="EnsemblGenomes-Gn:BSU12180" /db_xref="EnsemblGenomes-Tr:CAB13075" /db_xref="GOA:O34725" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="PDB:3CFU" /db_xref="SubtiList:BG13192" /db_xref="UniProtKB/Swiss-Prot:O34725" /translation="MKKVLLLLFVLTIGLALSACSQSSDASEKEKPKEKKSQEELEKE LDKELKKGGEPKTKKDDQIHKIGETFKAGHTNFTVNKVDRVQKGEYMNVGGAVNEETK TIKDDEERLIIEVTMENIGEDSISYNFIGFDLRDKNDQSVRPVFSIEEKGRILMGGTL VSGKKVTGVLSYVIPKGEQKHYTLVYNPFLADTNSSNTEERVKDDIDYLVKLD*" /label="yjhA CDS" gene 1204704..1205345 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /label="yjhA gene" downshifts complement(1204713) /Source="Nicolas_upshifts" /id="D675" /incds=0 /nref=7 /ntot=57 /MaxReadThrough="2.5769" /MaxDrop="3.81596" /score="-9.34186213" /energy="-3" /TU="NA" /idTUdmin="U998" /TUdmin=1386 /isTUend="FALSE" /label="downshifts" downshifts 1205318 /Source="Nicolas_upshifts" /id="D676" /incds=0 /nref=24 /ntot=186 /MaxReadThrough="4.29897" /MaxDrop="3.4683" /score="19.6571267" /energy="-17" /TU="U997" /idTUdmin="U996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 1205424..1206050 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /EC_number="3.6.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12483591, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ADP-ribose pyrophosphatase" /protein_id="NP_389101.2" /db_xref="EnsemblGenomes-Gn:BSU12190" /db_xref="EnsemblGenomes-Tr:CAB13076" /db_xref="GOA:C0SPC3" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG13193" /db_xref="UniProtKB/Swiss-Prot:C0SPC3" /translation="MIKVQTKWLERAQRIRAIAQAGLAFSKDVYDRERYEELMKLSAE MMADYSEKDIEVITDLWQGEKGYPTPKADVRGAVFRENQILLVREKHDELWSLPGGFC EIGLSPAENVVKEIKEESGYDTEPSRLLAVLDSHKHSHPPQPYHYYKIFIACSMTDGQ GETGIETNHAAFFPEDRLPPLSPKRNTPSQLSMLFDFLRHPDKKTIFD*" /label="yjhB CDS" gene 1205424..1206050 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /label="yjhB gene" downshifts 1206052 /Source="Nicolas_upshifts" /id="D677" /incds=0 /nref=97 /ntot=202 /MaxReadThrough="0.597580000000001" /MaxDrop="6.62023" /score="12.2319602" /energy="-7" /TU="NA" /idTUdmin="U997" /TUdmin=7 /isTUend="TRUE" /label="downshifts" downshifts complement(1206055) /Source="Nicolas_upshifts" /id="D678" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.18907" /MaxDrop="3.31161" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(1206081..1206359) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 14563871" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389102.1" /db_xref="EnsemblGenomes-Gn:BSU12200" /db_xref="EnsemblGenomes-Tr:CAB13077" /db_xref="SubtiList:BG13194" /db_xref="UniProtKB/Swiss-Prot:O34679" /translation="MAAQTDYKKQVVGILLSLAFVLFVFSFSERHEKPLVEGKKQENW HTVVDKASVKIYGSRLVEENKLKQKLGHKQADSILTLLKLANEKHITL*" /label="yjiA CDS" gene complement(1206081..1206359) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /label="yjiA gene" downshifts complement(1206099) /Source="Nicolas_upshifts" /id="D679" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="1.96302" /MaxDrop="5.98058" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1206388..1206399) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1206401..1206407) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1206407) /Source="Nicolas_upshifts" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1206409..1206825) /Source="Nicolas_S_feature" /locus_tag="new_1291003_1291419_c" /HighExp="S6, S7, S8, S5, BT, C30, Pyr, G/S, C90, B36" /AntisenseName="yjiB" /AntisenseCor="-0.25565388711625397" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S447" upshifts 1206577 /Source="Nicolas_upshifts" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1206578..1206597 /Source="Nicolas_upshift_promotors" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1206595..1206749 /Source="Nicolas_S_feature" /locus_tag="new_1291189_1291343" /HighExp="BC, T5.0H, T4.0H, C90, Sw, T3.30H, Lbstat, Diami, dia5, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.995811" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S448" CDS 1206750..1207940 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25587700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25587700; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP109B1, monooxygenase" /protein_id="NP_389103.1" /db_xref="EnsemblGenomes-Gn:BSU12210" /db_xref="EnsemblGenomes-Tr:CAB13078" /db_xref="GOA:O34374" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4RM4" /db_xref="SubtiList:BG13195" /db_xref="UniProtKB/Swiss-Prot:O34374" /translation="MNVLNRRQALQRALLNGKNKQDAYHPFPWYESMRKDAPVSFDEE NQVWSVFLYDDVKKVVGDKELFSSCMPQQTSSIGNSIINMDPPKHTKIRSVVNKAFTP RVMKQWEPRIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKA WSDLLVSTPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAE ETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHPELMPQAV EEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR HPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIENSVIYGLKSF RVKM*" /label="cypE CDS" gene 1206750..1207940 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /label="cypE gene" promotor_-10 complement(1206823..1206842) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1206825) /Source="Nicolas_upshifts" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1206856..1206865) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1207963..1209141 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 24893262, 27444326; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyphenols TDP-rhamnosyltransferase, promiscuous" /protein_id="NP_389104.1" /db_xref="EnsemblGenomes-Gn:BSU12220" /db_xref="EnsemblGenomes-Tr:CAB13079" /db_xref="GOA:O34539" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG13196" /db_xref="UniProtKB/Swiss-Prot:O34539" /translation="MKKYHISMINIPAYGHVNPTLALVEKLCEKGHRVTYATTEEFAP AVQQAGGEALIYHTSLNIDPKQIREMMEKNDAPLSLLKESLSILPQLEELYKDDQPDL IIYDFVALAGKLFAEKLNVPVIKLCSSYAQNESFQLGNEDMLKKIREAEAEFKAYLEQ EKLPAVSFEQLAVPEALNIVFMPKSFQIQHETFDDRFCFVGPSLGERKEKESLLIDKD DRPLMLISLGTAFNAWPEFYKMCIKAFRDSSWQVIMSVGKTIDPESLEDIPANFTIRQ SVPQLEVLEKADLFISHGGMNSTMEAMNAGVPLVVIPQMYEQELTANRVDELGLGVYL PKEEVTVSSLQEAVQAVSSDQELLSRVKNMQKDVKEAGGAERAAAEIEAFMKKSAVPQ *" /label="ppuG CDS" gene 1207963..1209141 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /label="ppuG gene" CDS complement(1209182..1209370) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="YP_003097710.1" /db_xref="EnsemblGenomes-Gn:BSU12229" /db_xref="EnsemblGenomes-Tr:CAX52600" /db_xref="UniProtKB/Swiss-Prot:C0H3Z3" /translation="METKKEEYETKGYDTSIVYEFNEYPDARSGRCDNCDYTLFKSSV KGGKFLRECRRCGMKKNI*" /label="yjzI CDS" gene complement(1209182..1209370) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /label="yjzI gene" downshifts complement(1209198) /Source="Nicolas_upshifts" /id="D680" /incds=0 /nref=94 /ntot=231 /MaxReadThrough="-0.1433" /MaxDrop="5.1712" /score="13.0160925" /energy="-9.5" /TU="NA" /idTUdmin="U1001" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1209396..1209415) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1209399) /Source="Nicolas_upshifts" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1209429..1209435) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1209457..1209464 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1209479..1209498 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1209490 /Source="Nicolas_upshifts" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1209505..1209524) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1209509) /Source="Nicolas_upshifts" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1209539..1209546) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1209544..1210356 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389105.1" /db_xref="EnsemblGenomes-Gn:BSU12230" /db_xref="EnsemblGenomes-Tr:CAB13080" /db_xref="GOA:O34394" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG13197" /db_xref="UniProtKB/Swiss-Prot:O34394" /translation="MGKGLLGKRVAIGGSRKTEEISTIIEKQGGIPVIRPLQGTVYLA EKQVEPDLRTFAEEKADWVIFTTGIGLETLVDMAEKIGLKDEFLQAIRQAKAACRGYK TLSALKKLGITPEASDEDGTTRGLIRSLEPHDFSGKTVMVQLHGEKAPALMAFLEEKG ASVLPILPYQHIPPEEETVERLCRELMNDEVDAVCFTTAIQVRSLFDFAKGRGYINEV KKVFEERAIAAAVGKVTAEALREEGITRLLAPEIERMGAMIVELAKYYEEKE*" /label="yjjA CDS" gene 1209544..1210356 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /label="yjjA gene" downshifts 1210335 /Source="Nicolas_upshifts" /id="D681" /incds=0 /nref=196 /ntot=254 /MaxReadThrough="3.61369" /MaxDrop="5.73094" /score="10.6328997" /energy="-14.5" /TU="U1002" /idTUdmin="U1002" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1210402..1211154) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_389106.1" /db_xref="EnsemblGenomes-Gn:BSU12240" /db_xref="EnsemblGenomes-Tr:CAB13081" /db_xref="GOA:O34684" /db_xref="InterPro:IPR005226" /db_xref="SubtiList:BG13198" /db_xref="UniProtKB/Swiss-Prot:O34684" /translation="MDYLSLSLTMIFVLIALFLSKSFKAGVEKDMIIATIRAAVQLLI IGYVLSLIFRGDHPVFILLMVLLMLAVAAQNVIKRKKNTIGSFWRVFAALAIVEIVTQ GILLSLHIIPLTARYVIPISGMVIGNSMVLSSLFLNRLNSEVGVRKEEIQLILSLGGT PKQSIQRILTSAMKMSMIPTLESQKTLGLVQLPGMMTGQILAGADPIQAVRFQLLIVF TTMASAALTCVILSVLTYPSLFTVHQQLKQNE*" /label="yjkA CDS" gene complement(1210402..1211154) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /label="yjkA gene" downshifts complement(1210411) /Source="Nicolas_upshifts" /id="D682" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="0.924970000000001" /MaxDrop="3.5673" /score="13.1058081" /energy="-12.8" /TU="NA" /idTUdmin="U1001" /TUdmin="-1210" /isTUend="FALSE" /label="downshifts" CDS complement(1211154..1211906) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389107.1" /db_xref="EnsemblGenomes-Gn:BSU12250" /db_xref="EnsemblGenomes-Tr:CAB13082" /db_xref="GOA:O34756" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13199" /db_xref="UniProtKB/Swiss-Prot:O34756" /translation="MEANDQTQNIPAISFRSVRKSYKQDGQTYDVLQDVTGDIQQGAI VAVLGPSGSGKSTLLSMCNLMRTPDSGEVNIYGKEVREWNVNELRRTAALAFQSAPVL DGTVRDNLSLVQRLHQSQLYSPEKLASLAGLPPELLDRSARDLSGGQRQRLSLARTLS NPSSILLLDEITSALDPVSALEIEELIKRQHQEKKWTVMWVTHNMEQAKRIADTIWFM ADGRLLEIAETDTFFSAPQHEAAKEFLKGGTR*" /label="yjkB CDS" gene complement(1211154..1211906) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /label="yjkB gene" CDS complement(1212026..1213000) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14627822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389108.1" /db_xref="EnsemblGenomes-Gn:BSU12260" /db_xref="EnsemblGenomes-Tr:CAB13083" /db_xref="GOA:O34428" /db_xref="InterPro:IPR032713" /db_xref="SubtiList:BG13200" /db_xref="UniProtKB/Swiss-Prot:O34428" /translation="MKAIVIGILASLFFAVTFILNRAMELSGGSWLWSSSLRFIFMVP FLCLIVIMRGTFTPLLLEMRKKPFYWIKWSFVGFVLFYAPITFAAAYGPGWLIAGTWQ ITIVAGVLLSPLFYVKQDMPGGPQLIRQKIPLVSLGTSVIILIGAALIQLQHAESLSG RMLLFSVLPVVIAAFAYPLGNRRMLEEYGGRLDTFQRVLGMTLASLPFWLILAAYGWW SDGLPTASQTVQSFIVAVSSGIIATVLFFWATDMVRDNPQKLAAVEATQSGEVIFALL GEIVLLSGVFPSLLSFAGLFIIIAGMMLHTFASQPRKPKKKAQSNLTA*" /label="yjlA CDS" gene complement(1212026..1213000) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /label="yjlA gene" downshifts complement(1212061) /Source="Nicolas_upshifts" /id="D683" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="1.84381" /MaxDrop="2.54799" /score="4.80318278" /energy="-14.5" /TU="NA" /idTUdmin="U1004" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1213021..1213040) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1213047) /Source="Nicolas_upshifts" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1213049..1215555) /Source="Nicolas_S_feature" /locus_tag="new_1297643_1300149_c" /HighExp="Lbstat, S2, M0t90, nit, BT, M40t90, ferm, BC, C30, Gly" /AntisenseName="ndh" /AntisenseCor="-0.74506751931257098" /AntisenseRegPval="-48.1" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S449" promotor_-35 complement(1213055..1213062) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1213083..1213089 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1213104..1213122 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1213107 /Source="Nicolas_upshifts" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1213132..1213629 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10704478" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; cupin family" /protein_id="NP_389109.1" /db_xref="EnsemblGenomes-Gn:BSU12270" /db_xref="EnsemblGenomes-Tr:CAB13084" /db_xref="GOA:O34612" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014500" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG13201" /db_xref="UniProtKB/Swiss-Prot:O34612" /translation="MERETQTYFFPDDGRIPNHPDFPLVVYQNALKDTGLAERIVTRH GWSNSWSGSVFPYHHYHSNTHEVLIALRREAVIQFGGEKGAAIPFKSGDAVVIPAGVG HKKLSSSPDFTVLGAYPGGVQYDMKTGKPNEREEAVKQIKQAALPANDPITGKREPLL EIWVK*" /label="yjlB CDS" gene 1213132..1213629 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /label="yjlB gene" S_feature 1213630..1213743 /Source="Nicolas_S_feature" /locus_tag="new_1298224_1298337" /HighExp="Etha, M9-stat, B60, Salt, Gly, LPhT, Heat, Sw, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S450" promotor_-35 1213723..1213727 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1213743..1213762 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1213745..1214017 /Source="Nicolas_S_feature" /locus_tag="new_1298339_1298611" /HighExp="LBGtran, dia5, Lbexp, LBGexp, dia0, HPh, aero, LPh, BMM, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S451" upshifts 1213745 /Source="Nicolas_upshifts" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1214018..1214440 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16513748, 17015645, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389110.1" /db_xref="EnsemblGenomes-Gn:BSU12280" /db_xref="EnsemblGenomes-Tr:CAB13085" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13202" /db_xref="UniProtKB/Swiss-Prot:O34633" /translation="MPETIDQTNASVSQSQQDLIDQLLKPEVQESLTVLVDQLPKLTE LVNILTKSYDFAQSVATDEVLKSDTVGAITEILEPVKETAKEVAATAIEAKDRAEASN ETIGLFGLLRMLKDPQAQKLFRFANSYLEVMNERENQK*" /label="yjlC CDS" gene 1214018..1214440 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /label="yjlC gene" CDS 1214480..1215658 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /EC_number="1.6.99.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6816592, 16513748, 17015645, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6816592, 16513748, 17015645, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH dehydrogenase" /protein_id="NP_389111.1" /db_xref="EnsemblGenomes-Gn:BSU12290" /db_xref="EnsemblGenomes-Tr:CAB13086" /db_xref="GOA:P80861" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13203" /db_xref="UniProtKB/Swiss-Prot:P80861" /translation="MSKHIVILGAGYGGVLSALTVRKHYTKEQARVTVVNKYPTHQII TELHRLAAGNVSEKAVAMPLEKLFKGKDIDLKIAEVSSFSVDKKEVALADGSTLTYDA LVVGLGSVTAYFGIPGLEENSMVLKSAADANKVFQHVEDRVREYSKTKNEADATILIG GGGLTGVELVGELADIMPNLAKKYGVDHKEIKLKLVEAGPKILPVLPDDLIERATASL EKRGVEFLTGLPVTNVEGNVIDLKDGSKVVANTFVWTGGVQGNPLVGESGLEVNRGRA TVNDFLQSTSHEDVFVAGDSAVYFGPDGRPYPPTAQIAWQMGELIGYNLFAYLEGKTL ETFKPVNSGTLASLGRKDAVAIIGANSTPLKGLPASLMKEASNVRYLTHIKGLFSLAY *" /label="ndh CDS" gene 1214480..1215658 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /label="ndh gene" promotor_no_box 1215489..1215589 /Source="Nicolas_upshift_promotors" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(1215547..1215565) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1215549 /Source="Nicolas_upshifts" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1215555) /Source="Nicolas_upshifts" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1215577..1215585) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1215657 /Source="Nicolas_upshifts" /id="D684" /incds=0 /nref=220 /ntot=278 /MaxReadThrough="2.01042" /MaxDrop="8.69373" /score="30.6421047" /energy="-23.1" /TU="NA" /idTUdmin="U1005" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 1215766..1215773 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1215788..1215807 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1215813 /Source="Nicolas_upshifts" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="upshifts" CDS 1215856..1217277 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /EC_number="5.3.1.12" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galacturonate isomerase" /protein_id="NP_389112.1" /db_xref="EnsemblGenomes-Gn:BSU12300" /db_xref="EnsemblGenomes-Tr:CAB13087" /db_xref="GOA:O34808" /db_xref="InterPro:IPR003766" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13204" /db_xref="UniProtKB/Swiss-Prot:O34808" /translation="MEPFMGKNFLLKNETAVSLYHNYAKDMPIIDYHCHLSPKEIYEN KTFQNITEAWLYGDHYKWRIMRANGIEETYITGDAPDEEKFMAWAKTVPMAIGNPLYN WTHLELQRFFGIYEILNEKSGSAIWKQTNKLLKGEGFGARDLIVKSNVKVVCTTDDPV DSLEYHLLLKEDKDFPVSVLPGFRPDKGLEINREGFPEWVQALEDAAAISITTYDEFL KALEKRVRFFHSAGGRVSDHAIDTMVFAETTKEEAGRIFSDRLQGTEVSCEDEKKFKT YTLQFLCGLYAELDWAMQFHINALRNTNTKMMKRLGPDTGYDSMNDEEIAKPLYKLLN SVEMKNQLPKTILYSLNPNDNYVIASMINSFQDGITPGKIQFGTAWWFNDTKDGMLDQ MKALSNVGLFSRFIGMLTDSRSFLSYTRHEYFRRIVCNLIGEWVENGEVPRDMELLGS IVQGICYDNAKHYFQFQEEKANV*" /label="uxaC CDS" gene 1215856..1217277 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /label="uxaC gene" CDS 1217345..1218724 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+:altronate/mannonate symporter" /protein_id="NP_389113.1" /db_xref="EnsemblGenomes-Gn:BSU12310" /db_xref="EnsemblGenomes-Tr:CAB13088" /db_xref="GOA:O34961" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13205" /db_xref="UniProtKB/Swiss-Prot:O34961" /translation="MRTELANKVVSVETEKRLSLKEKMSYGFGDFGNGFMFDLGQIYL LKYFTDVAGIPAAMAGGIFLVSKLFAAITDPIVGSSIDYRKNIGKRGKFRPYLLIGSI VLAVLTVLIFLSPNVSTTGKLIYAYASYMIWGIGYSFVNIPYGSLGAAMTQNSEDRTS ISTFRQIGSLGALFITSVAVMPLLVKFDNPKVGYPVVMGLFAALGVFWFYICYRNCKE RIIISEAPKEKLTLSSVVKTFITNKPLLTLVLMTIFSISAYNIKSAMLVYFAQYNLGN VELMAYMNFIIIGSSFLGVVFLPKLVKMFGKKRTAMIGFGISVAADLINFMLPSNVYV FTILASIAFIGISIPNGITWALVSDIIDYGEWKSGERKEATTYSLFNFSRKLAQSLSG FLSGIGLGIIGYVPNAVQTAQALIGIKALLLLYPAIALALAMFIIGFLYKLTDQQHAQ IVQDLHQKS*" /label="exuM CDS" gene 1217345..1218724 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /label="exuM gene" promotor_-10 complement(1217864..1217883) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1217869) /Source="Nicolas_upshifts" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1217897..1217904) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1218749 /Source="Nicolas_upshifts" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1218759..1218766 /Source="Nicolas_upshift_promotors" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1218761..1218828 /Source="Nicolas_S_feature" /locus_tag="new_1303355_1303422" /HighExp="S4, S5, S6, S3, S8, S7, T5.0H, T4.0H, T3.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S452" CDS 1218829..1219842 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655, 16788182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389114.1" /db_xref="EnsemblGenomes-Gn:BSU12320" /db_xref="EnsemblGenomes-Tr:CAB13089" /db_xref="GOA:O34736" /db_xref="InterPro:IPR003767" /db_xref="InterPro:IPR036111" /db_xref="SubtiList:BG13206" /db_xref="UniProtKB/Swiss-Prot:O34736" /translation="MKTITIAAEEAKELVWQKLDGAGLNERDAEKVADVLVHADLRNV HSHGVLHTEHYVNRLLAGGINPGAQPVFKETGPVTGVLDGDDGFGHVNCDMAMDHAID MAKKKGVGMVTAVNSSHCGALSYFVQKAADEKLIGMAMTHTDSIVVPFGGRTPILGTN PIAYGVPAKHKKPFILDMATSKVAFGKILQAREEGKEIPEGWGVDENGEAVTDPDKVV SLSTFGGPKGYGLSIVVDVFSGLLAGAAFGPHIAKMYNGLDQKRKLGHYVCAINPSFF TDWDTFLEQMDAMIDELQQSPPAVGFERVYVPGEIEQLHEERNKKNGISIARSVYEFL KSR*" /label="yjmC CDS" gene 1218829..1219842 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /label="yjmC gene" CDS 1219848..1220867 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389115.1" /db_xref="EnsemblGenomes-Gn:BSU12330" /db_xref="EnsemblGenomes-Tr:CAB13090" /db_xref="GOA:O35045" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13207" /db_xref="UniProtKB/Swiss-Prot:O35045" /translation="MKAVQVRKAYDLVTAEVKKPVLSKDDEVLVKVKRVGICGSDMHI YHGTNPLATLPRVIGHEVTGQVEAVGANVQSLKPGDHVVIEPISYCGSCYACRKGRPN VCAKLSVFGVHEDGGMREYIVLPERQLHAVSKDLPWEEAVMAEPYTIGAQAVWRGQVE KGDTVLIQGAGPIGICVLKMAKLAGAAVMMTDLNNERLAFAKENGADAVVNVQAEHVA ERVLEWTGNEGANVVIDAVCLPETFALSIEAVSPAGHVVVLGFDERAAQISQLPITKK EVTITGSRLQTNQFPKVVELLNGGRLMHNGLVTHTFSVDDVHHAFQFIKEHPDQVRKA VITFD*" /label="yjmD CDS" gene 1219848..1220867 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /label="yjmD gene" CDS 1220892..1221971 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /EC_number="4.2.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9579062, 9882655, 10368143, 25145794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-mannonate dehydratase" /protein_id="NP_389116.1" /db_xref="EnsemblGenomes-Gn:BSU12340" /db_xref="EnsemblGenomes-Tr:CAB13091" /db_xref="GOA:O34346" /db_xref="InterPro:IPR004628" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG13208" /db_xref="UniProtKB/Swiss-Prot:O34346" /translation="MNMTFRWYGRGNDTVTLEYVKQIPGVKGIVWALHQKPVGDVWEK EEIRAETEYIQSYGFHAEVVESVNVHEAIKLGNEERGRYIENYKQTIRNLAGFGVKVI CYNFMPVFDWTRTDMFRPLEDGSTALFFEKAKVESLDPQELIRTVEEASDMTLPGWEP EKLARIKELFAAYRTVDEEKLWDNLSFFLQEILPVAEAYGVQMAIHPDDPPWPIFGLP RIITGEASYKKLRAISDSPSNCITLCTGSMGANPANDMVEIAKTYAGIAPFSHIRNVK IYENGDFIETSHLTKDGSINIQGVMEELHKQDYEGYVRPDHGRHLWGEQCRPGYGLYD RALGIMYLNGLWDAYEAMAKKEVGI*" /label="uxuA CDS" gene 1220892..1221971 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /label="uxuA gene" CDS 1221968..1222804 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /EC_number="1.1.1.57" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructuronate reductase" /protein_id="NP_389117.1" /db_xref="EnsemblGenomes-Gn:BSU12350" /db_xref="EnsemblGenomes-Tr:CAB13092" /db_xref="GOA:O34896" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13209" /db_xref="UniProtKB/Swiss-Prot:O34896" /translation="MIPLHENLAGKTAVITGGSGVLCSAMARELARHGMKVAILNRTA EKGQAVVKEITAAGGTACAVAADVLDRMSLERAKEDILGQFGAVDLLINGAGGNHPDA ITDVETYEEAGEGQSFFDMDERGFLTVFSTNFTGAFLASQVFGKELLKADSPAIINLS SMSAYSPMTKVPAYSAAKASINNFTMWMAVHFAETGLRVNAIAPGFFLTKQNHDLLIN QDGTFTSRSHKIIAGTPMKRFGKPEDLLGTLLWLADESYSGFVTGITVPVDGGFMAYS GV*" /label="uxuB CDS" gene 1221968..1222804 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /label="uxuB gene" CDS 1222852..1224120 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8320243, 9579062, 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="hexuronate transporter" /protein_id="NP_389118.1" /db_xref="EnsemblGenomes-Gn:BSU12360" /db_xref="EnsemblGenomes-Tr:CAB13093" /db_xref="GOA:O34456" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13210" /db_xref="UniProtKB/Swiss-Prot:O34456" /translation="MFSKDKLPVILFLFLAGVINYLDRSALSIAAPFIQDDLTLSATQ MGLIFSSFSIGYAIFNFLGGVASDRYGAKLTLFVAMVVWSLFSGAVALAFGFVSLLII RILFGMGEGPLSATINKMVNNWFPPTQRASVIGVTNSGTPLGGAISGPIVGMIAVAFS WKVSFVLIMIIGLIWAVLWFKFVKEKPQETIKEAPAIKAETSPGEKIPLTFYLKQKTV LFTAFAFFAYNYILFFFLTWFPSYLVDERGLSVESMSVITVIPWILGFIGLAAGGFVS DYVYKKTARKGVLFSRKVVLVTCLFSSAVLIGFAGLVATTAGAVTLVALSVFFLYLTG AIYWAVIQDVVDQNNVGSVGGFMHFLANTAGIIGPALTGFIVDQTGTFSGAFLLAGGL AVFASLAVIRFVRPIIGKPAGTEAENPVSY*" /label="exuT CDS" gene 1222852..1224120 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /label="exuT gene" promotor_-35 1224064..1224067 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1224083..1224087 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1224085 /Source="Nicolas_upshifts" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1224153..1224172 /Source="Nicolas_upshift_promotors" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1224153 /Source="Nicolas_upshifts" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" CDS 1224208..1225209 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9579062, 9882655" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9579062, 9882655; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_389119.1" /db_xref="EnsemblGenomes-Gn:BSU12370" /db_xref="EnsemblGenomes-Tr:CAB13094" /db_xref="GOA:Q9JMQ1" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13211" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ1" /translation="MVTIKDIAKLANVSHTTVSRALNNSPYIKEHTKKKILELAEQLN YTPNVNAKSLAMQKSHTIGLFFTSITNGTSHSFFADTIKGVNQAISEDYNLYVRGIDD LKNYDSVTPMRYDGIILMSQSDIDNSFIYHIREKNIPLVVLNRDIDDRTITNILSNDK EGSQEAVEYFIQSGHQDIAIIEGIEGFKSSQQRKEGYLSALIQHHIPIKHEYSVKGQY DMESGFQAMERLLALPNPPTAVFCSNDDMAIGAMNAIFAKGLRVPDDISVIGFDDIGF SQYITPRLSTVKRPVEKISVLGAQKLLSLISEPETKAEKILENTEFMVRDSVRRLTT* " /label="exuR CDS" gene 1224208..1225209 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /label="exuR gene" promotor_no_box complement(1224891..1224991) /Source="Nicolas_upshift_promotors" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1224931) /Source="Nicolas_upshifts" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1225185 /Source="Nicolas_upshifts" /id="D685" /incds=0 /nref=2 /ntot=132 /MaxReadThrough="2.47166" /MaxDrop="3.11543" /score="12.2153519" /energy="-7.4" /TU="NA" /idTUdmin="U1011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1225286..1226728 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /EC_number="1.1.1.58" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tagaturonate reductase (altronate oxidoreductase)" /protein_id="NP_389120.1" /db_xref="EnsemblGenomes-Gn:BSU12380" /db_xref="EnsemblGenomes-Tr:CAB13095" /db_xref="GOA:O34354" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023668" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13212" /db_xref="UniProtKB/Swiss-Prot:O34354" /translation="MQKLNKNVYDHYTQYPEKILQFGEGNFLRGFIDWQIDQLNQHTD FNGSVAVVQPRGSEKIKRLNEQDGLYTLFLQGMKDGEAVNEHMIINSISRGIDLFSDY EAYKELASSERLRFIISNTTEAGIVCDEKDRLEDRPQKTFPGKLTAFLYFRYQAFKGD QTKGCVLIPCELIENNGEKLRETVLHYAHLWKLEEGFTQWIHEANTFCNSLVDRIVPG FPVDSIDEITADLGYQDDLIVVGEQYYLWVIEGPDWIGKELPFAAAGLHTKIVSDLTP YRTKKVRILNGAHTAMTPVALLYGLKTVRDAVEHPEVGRFIRELIDDEILPVLKMEGL SQYADDVLNRFKNPYIKHYLESIALNAISKFKTRNLPTLKEYAEQKGQLPERLVFSFS ALLYFYHDNETLQDDPAVLQFFKEVWCQEDGDMLRIASRVLGEQRLWGADLNEIPKLT DRVAVYLNHIHELGMQRALEQYCIQGGEVR*" /label="uxaB CDS" gene 1225286..1226728 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /label="uxaB gene" CDS 1226725..1228218 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /EC_number="4.2.1.7" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="altronate dehydratase" /protein_id="NP_389121.2" /db_xref="EnsemblGenomes-Gn:BSU12390" /db_xref="EnsemblGenomes-Tr:CAB13096" /db_xref="GOA:O34673" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="SubtiList:BG13213" /db_xref="UniProtKB/Swiss-Prot:O34673" /translation="MKSFIKIHKQDNVLLALRDIQKGERLHAYGVSIEVKDDIKRGHK IALQSIKENDSIVKYGFPIGHASQDISIGEHIHVHNTKTNLSDIQLYSYTPRFDENPY SNENRTFKGFRRENGDAGVRNELWIVPTVGCVNGIAEKMLQRFVRETGDIAPFDNVLV LKHQYGCSQLGDDHENTKQILLNAIRHPNAGGVLVLGLGCENNELARMKEALQDVNLK RVKFLESQSVTDEMEAGVALLKEIHEAAKGDKREDIPLSELKIGLKCGGSDGFSGITA NPLLGRFSDYLIAQGGSTVLTEVPEMFGAETILMQRAANEEVFHKIVDLINDFKQYFI KHDQPVYENPSPGNKAGGISTLEDKSLGCTQKAGISPVTDVLKYGEVLKTKGLTLLSA PGNDLIASSALAAAGCQIVLFTTGRGTPFGTFVPTVKVATNTELYEAKPHWIDFNAGL LAEDDVHEEYVLREFIHYMIEVASGQLVNHEKNDFKELAIFKSGVTL*" /label="uxaA CDS" gene 1226725..1228218 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /label="uxaA gene" CDS complement(1228257..1229021) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389122.1" /db_xref="EnsemblGenomes-Gn:BSU12400" /db_xref="EnsemblGenomes-Tr:CAB13097" /db_xref="GOA:O34578" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13214" /db_xref="UniProtKB/Swiss-Prot:O34578" /modified_by="User" /translation="MSVSIILMGLFVGALVGLTGVGGAALLTPLLIVLGINPSIAVGT DLVYNSITKLFGVASHWRQKTINFKLVKYLAIGGIPSASLAIGILHLFPAFHQHQEEI IKHALGYVLTLVAISIIVRLFLDRKLRPNRWQLMPLENKRALTILIGVVFGFIVGLTS IGSGSLFAIAMIYLFNMKASQIVGTDIAHAFLLVTAAGILNASFGSVDYMLAANLLLG SIPGVLIGSHLSPRFSPRPLQFIMASIILVSGLKLI*" /label="Delta6_BSU_12400_SNPvariant" gene complement(1228257..1229021) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /modified_by="User" /label="Delta6_BSU_12400_SNPvariant" downshifts complement(1228276) /Source="Nicolas_upshifts" /id="D686" /incds=0 /nref=96 /ntot=170 /MaxReadThrough="1.34004" /MaxDrop="4.60564" /score="6.47747687" /energy="-11.3" /TU="NA" /idTUdmin="U1015" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" Polymorphism join(1228789,1228791) /Source="geneious" /ID="SNP_BsDelta6_1313384_1313384" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="S -> G" /CDS_Position=232 /Change="T -> C" /Codon_Change="AGT -> GGT" /Coverage=150 /locus_tag="BSU_12400" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=149 /comment="Delta6_BSU_12400_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" SCAR join(1229048,1229055) /created_by="User" /modified_by="User" /label="TF8A" N_region 1229049..1229054 /created_by="User" /note_="EcoRI site (GAATTC)" /modified_by="User" /label="TF8A" CDS <1229057..1229377 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /EC_number="3.5.1.28" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7921239, 9555893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921239, 9555893; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_389164.1" /db_xref="EnsemblGenomes-Gn:BSU12810" /db_xref="EnsemblGenomes-Tr:CAB13138" /db_xref="GOA:P39800" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="InterPro:IPR036779" /db_xref="PDB:3HMB" /db_xref="PDB:3RDR" /db_xref="SubtiList:BG10962" /db_xref="UniProtKB/Swiss-Prot:P39800" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /translation="PNLIRVGQVLIVSAPSAAEKPELYPLPDGIIQLTTPYTSGEHVF QVQRALAALYFYPDKGAVNNGIDGVYGPKTADAVARFQSVNGLTADGIYGPATKEKIA AQLS*" /label="Delta6_pseudo_BSU_12810" gene <1229057..1229377 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /label="Delta6_pseudo_BSU_12810" downshifts 1229386 /Source="Nicolas_upshifts" /id="D696" /incds=0 /nref=29 /ntot=162 /MaxReadThrough="3.77255" /MaxDrop="5.00305" /score="30.9009227" /energy="-12.5" /TU="U1029,U1033" /idTUdmin="U1029" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" S_feature complement(1229395..1229598) /Source="Nicolas_S_feature" /locus_tag="new_1348200_1348403_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.798" /TUlongSig="NA" /TUlongPSig="NA" /label="S458" CDS complement(1229414..1229551) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type r: regulator" /codon_start=1 /transl_table=11 /product="three component toxin / antitoxin / antitoxin SpoIISABC, antitoxin C" /protein_id="YP_009513952.1" /translation="MSGDTVKKLVRRVKFVDYGRFGLSGYSLRVRERSAGIIKKLKKK K*" /label="spoIISC CDS" gene complement(1229414..1229551) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /label="spoIISC gene" downshifts complement(1229438) /Source="Nicolas_upshifts" /id="D697" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="2.75573" /MaxDrop="4.3776" /score="24.0186344" /energy="-12.5" /TU="U1034" /idTUdmin="U1035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1229637..1229807) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptotic control system component B (antitoxin B)" /protein_id="NP_389165.1" /db_xref="EnsemblGenomes-Gn:BSU12820" /db_xref="EnsemblGenomes-Tr:CAB13139" /db_xref="GOA:O34800" /db_xref="InterPro:IPR025897" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12678" /db_xref="UniProtKB/Swiss-Prot:O34800" /translation="MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKEN ERLIDEYKRKKA*" /label="spoIISB CDS" gene complement(1229637..1229807) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /label="spoIISB gene" downshifts complement(1229643) /Source="Nicolas_upshifts" /id="D698" /incds=0 /nref=6 /ntot=86 /MaxReadThrough="4.69899" /MaxDrop="3.0872" /score="24.0186344" /energy="-12.5" /TU="U1034,U1035" /idTUdmin="U1035" /TUdmin="-205" /isTUend="FALSE" /label="downshifts" CDS complement(1229807..1230553) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptosis factor (ABC toxin/antitoxin/antitoxin system)" /protein_id="NP_389166.1" /db_xref="EnsemblGenomes-Gn:BSU12830" /db_xref="EnsemblGenomes-Tr:CAB13140" /db_xref="GOA:O34853" /db_xref="InterPro:IPR025940" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12677" /db_xref="UniProtKB/Swiss-Prot:O34853" /translation="MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLL FVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAFIFLSAYVKKLAGSELETDTREI LEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSD SIVTEFDYLLFTSLTSIYDLVLPIEEEGEG*" /label="spoIISA CDS" gene complement(1229807..1230553) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /label="spoIISA gene" promotor_-10 complement(1230388..1230407) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1230405) /Source="Nicolas_upshifts" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1230423..1230430) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1230579..1230597) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1230592) /Source="Nicolas_upshifts" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1230613..1230618) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1230663..1231664) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10784039, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative low-affinity inorganic phosphate transporter" /protein_id="NP_389167.2" /db_xref="EnsemblGenomes-Gn:BSU12840" /db_xref="EnsemblGenomes-Tr:CAB13141" /db_xref="GOA:O34436" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13226" /db_xref="UniProtKB/Swiss-Prot:O34436" /translation="MDILLILTILIVICALAFDFINGFHDTANAIATSVSTKALKPRH AIILAAVMNFVGAMTFTGVAKTITKDIVDPYTLENGSVVILAALLAAIAWNLITWYYG IPSSSSHAIIGAIAGAAIAAAGFAALNYKGFIKIIEALILSPIIAFVLGFILYSIVKL IFKDSNLAKTNKQFRRVQIVTAALQSYTHGTNDAQKAMGIITMALITANLHTSANDIP TWVQFACATAMGLGTSIGGWKIIKTVGGKIMKIRPVNGVSADLTGAAIIFGATFIHLP VSTTHVISSSILGVGASHRVKGVNWGTAKRMLITWVITLPISATLGAIAYFILNMIF* " /label="pitB CDS" gene complement(1230663..1231664) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /label="pitB gene" downshifts complement(1230692) /Source="Nicolas_upshifts" /id="D699" /incds=0 /nref=205 /ntot=253 /MaxReadThrough="3.49591" /MaxDrop="5.81942" /score="21.8061263" /energy="-11" /TU="U1036,U1038" /idTUdmin="U1037" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1231677..1232294) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696772, 14563871; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PitB transporter accessory protein" /protein_id="NP_389168.1" /db_xref="EnsemblGenomes-Gn:BSU12850" /db_xref="EnsemblGenomes-Tr:CAB13142" /db_xref="InterPro:IPR018445" /db_xref="SubtiList:BG13225" /db_xref="UniProtKB/Swiss-Prot:O34454" /translation="MIRRKKDKFSLLLTEIAKNIDETAEYFVNFKVTNQTTLKEFADT LKEYETKGDNHVHVMIKELNKAFITPIEREDILQLTNSLDDVLDGIEHFSAMMEIFSI TSSDEHIDKFSGYIRECAKEILITIELLAENRLKDIQPHAIKIKEYEHSCDNLHRKSL KNLFGNETDPIKVIQYREIYETLEEIADSCQSVANNLETIIMKNA*" /label="ykaA CDS" gene complement(1231677..1232294) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /label="ykaA gene" promotor_-10 complement(1232330..1232349) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1232332) /Source="Nicolas_upshifts" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1232334..1232431) /Source="Nicolas_S_feature" /locus_tag="new_1351139_1351236_c" /HighExp="H2O2, Etha, dia15, Diami, Paraq, Heat, dia5, Salt, LBGstat, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.972, 0.987" /TUlongSig="SigA" /TUlongPSig="0.992" /label="S459" promotor_-35 complement(1232365..1232369) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1232411..1232430) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1232431) /Source="Nicolas_upshifts" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1232445..1232452) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1232476..1232495) /Source="Nicolas_upshift_promotors" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1232488) /Source="Nicolas_upshifts" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1232570..1233886) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17344220, 19419962, 20610400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17344220, 19419962, 20610400; Product type t : transporter" /codon_start=1 /transl_table=11 /product="serine / threonine exchanger" /protein_id="NP_389169.1" /db_xref="EnsemblGenomes-Gn:BSU12860" /db_xref="EnsemblGenomes-Tr:CAB13143" /db_xref="GOA:O34739" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG13227" /db_xref="UniProtKB/Swiss-Prot:O34739" /translation="MHTEDNGLKKEIGLLFALTLVIGTIIGSGVFMKPGAVLAYSGDS KMALFAWLLGGILTLAGGLTIAEIGTQIPKTGGLYTYLEEVYGEFWGFLCGWVQIIIY GPAIIGALGLYFGSLMANLFGWGSGLSKVIGIIAVLFLCVINIIGTKYGGFVQTLTTI GKLIPIACIIVFGLWKGDQHIFTAVNESISDMNFGAAILATLFAYDGWILLAALGGEM KNPEKLLPRAMTGGLLIVTAIYIFINFALLHILSANEIVTLGENATSTAATMLFGSIG GKLISVGIIVSIFGCLNGKVLSFPRVSFAMAERKQLPFAEKLSHVHPSFRTPWIAISF QIALALIMMLISNPDKLSEISIFMIYIFYVMAFFAVFILRKRAKGEKRAYSVPLYPFM PILAIAGSFFVLGSTLITDTMSCGLSILIGLAGLPVYYGMKKRKAS*" /label="steT CDS" gene complement(1232570..1233886) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /label="steT gene" downshifts complement(1232585) /Source="Nicolas_upshifts" /id="D700" /incds=0 /nref=3 /ntot=92 /MaxReadThrough="3.59461" /MaxDrop="3.97157" /score="23.3119204" /energy="-14.4" /TU="U1039" /idTUdmin="U1039" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1233933..1233952) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-10" upshifts complement(1233949) /Source="Nicolas_upshifts" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="upshifts" promotor_-35 complement(1233967..1233970) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-35" promotor_-35 1234169..1234176 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1234191..1234210 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1234203..1234274 /Source="Nicolas_S_feature" /locus_tag="new_1353008_1353079" /HighExp="Etha, dia15, Salt, Heat, dia5, Diami, H2O2, M9-stat, MG 25, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.964" /TUlongSig="NA" /TUlongPSig="NA" /label="S460" upshifts 1234203 /Source="Nicolas_upshifts" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="upshifts" CDS 1234275..1235225 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /EC_number="1.13.11.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17407181, 17725564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 17725564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroquinone-specific extradiol dioxygenase" /protein_id="NP_389170.1" /db_xref="EnsemblGenomes-Gn:BSU12870" /db_xref="EnsemblGenomes-Tr:CAB13144" /db_xref="GOA:O34689" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13228" /db_xref="UniProtKB/Swiss-Prot:O34689" /translation="MKVNGIHHVSALTADAQKNLDFYKKVLGLKLVKKSVNQDEPTMY HLFYGDEVANPGTELTFFEIPRIAPFHAGTNSISSIGLRVPGTEALHYWKERFEEQQV THSGISKRAGRDILAFQDHEGQRLVLTADEEGKGYGLPVKQSGIPEEFSFRGLGPVEL TVPYAEPTLHVLTNILGFTEISREPVEGQGTAVILESGEGGAATEIHLIERNDLPRER QGKGSVHHVAFRVRDEEELAGWHRIISREGFSNSGIVERYYFKALYFREPNGILFELS TDGPGFMVDENLDELGQTIALPPYLEHRRAEIEAKLKPIQ*" /label="mhqA CDS" gene 1234275..1235225 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /label="mhqA gene" downshifts 1235213 /Source="Nicolas_upshifts" /id="D701" /incds=0 /nref=95 /ntot=231 /MaxReadThrough="0.70251" /MaxDrop="5.11652" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1040" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 1235326..1235472 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513953.1" /translation="MLIGRNGLKPFANMGDWYGMASAKILSLFINSLFIFACYTISKL DKKE*" /label="hypothetical protein CDS" gene 1235326..1235472 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /label="gene" CDS 1235480..1237630 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane glycosyl transferase" /protein_id="NP_389171.2" /db_xref="EnsemblGenomes-Gn:BSU12880" /db_xref="EnsemblGenomes-Tr:CAB13145" /db_xref="GOA:O34575" /db_xref="SubtiList:BG13229" /db_xref="UniProtKB/Swiss-Prot:O34575" /translation="MEKKKRELDIVLLLILLASAFLNIYNIWKDDTVNPYYTAAVTSM MQSFHNFFYASFDAAGFITVDKPPVTYQIQTISALIFGMHGWSVILPQALAGVGSVLL MYLLIKPTFGKTAARIASFVMACTPIAVAVARTNNVDALLVFFLLLATWLLFKAIRKG KLIWLLAAFFVVGVGFNTKMLQAYMILPAFLLFYLIAANATIKKKIVSLVSALAVLAA VSLSWPLIVDNIPASKRPYIGSSQTNSVLELAFGYNGIQRLTGQNSGGGQGAPNKDAS KEMSSSDNTQAPPNQSSSNSSSSDGKSSNGNMAAPPSNGQMPSGGQGGPPSGGDGGQG GPGGDGGKGGTGTGSKMQSGSGMFGTGTPGPLRLFQQELSDQISWLLPFAIFGIAGLL IAGARERRRLSVEQKETVFWVAWLVPIAGFFSVAEFFHHYYLIMLAPPIAALVGAGWV ALVHLYRNQTGWKAWLLPGAIIATTGFELFILRNYNDQIGVGWSIGVGVIGVLSAIAL LLFKQRQKPFSYYVSLAALLALLVMPMYWASTPLLYGGNSSLPETGPQLASMSGKGMG MSDATVNEKLIKYLEENNSGAEYLFATTDSNTAAPYIIKTKKAVMAIGGYSGSDPAIT LTQFKKLVKEGKVKYFLASGMGRGGNNDIVEWVEKNGKEVASEKWQSSSDQKTENTDS ADTSSSKASGENGKMGGPGGMNQSATLYELHADE*" /label="ykcB CDS" gene 1235480..1237630 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /label="ykcB gene" promotor_no_box 1236369..1236469 /Source="Nicolas_upshift_promotors" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1236429 /Source="Nicolas_upshifts" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1236517 /Source="Nicolas_upshifts" /id="D702" /incds=1 /nref=4 /ntot=10 /MaxReadThrough="0.56615" /MaxDrop="4.44711" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1041" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1237642..1238613 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /EC_number="2.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389172.2" /db_xref="EnsemblGenomes-Gn:BSU12890" /db_xref="EnsemblGenomes-Tr:CAB13146" /db_xref="GOA:O34319" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13230" /db_xref="UniProtKB/Swiss-Prot:O34319" /translation="MSRHIQYSIVVPVYNEELVIHETYQRLKEVMDQTKENYELLFVN DGSKDRSIEILREHSLIDPRVKIIDFSRNFGHQIAITAGMDYAQGNAIVVIDADLQDP PELILEMIEKWKEGYEVVYAVRTKRKGETFFKKQTAAMFYRLLSGMTDIDIPIDTGDF RLMDRKVCDEMKRLKEKNPFVRGLVSWVGFKQTAVEYVRDERLAGETKYPLKKMLKLS MDGITTFSHKPLKLASYAGILMSGTGFLYMFIVLYLKLFTDSTITGWSSLIVIQLLFS GIVLLILGVIGEYIGRIYDEAKDRPLYIVQKSYGIENKRLYRDQHMS*" /label="ykcC CDS" gene 1237642..1238613 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /label="ykcC gene" S_feature complement(1237970..1238611) /Source="Nicolas_S_feature" /locus_tag="new_1356775_1357416_c" /HighExp="T-0.40H, T0.0H, Salt, T0.30H, T-1.10H, C30, T-1.40H, S0, H2O2, T1.0H" /AntisenseName="ykcC" /AntisenseCor="9.6017422892053297E-4" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S461" downshifts complement(1238656) /Source="Nicolas_upshifts" /id="D703" /incds=0 /nref=9 /ntot=114 /MaxReadThrough="4.36795" /MaxDrop="4.15844" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=489 /isTUend="FALSE" /label="downshifts" S_feature complement(1238681..1239047) /Source="Nicolas_S_feature" /locus_tag="new_1357486_1357852_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T0.0H, T2.30H, T-0.40H, T3.0H, Salt, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99893799999999999" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S462" downshifts complement(1238724) /Source="Nicolas_upshifts" /id="D704" /incds=0 /nref=17 /ntot=157 /MaxReadThrough="6.61192" /MaxDrop="3.74411" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=421 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1239027..1239042) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1239047) /Source="Nicolas_upshifts" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1239054..1239063) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1239131..1240480) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /EC_number="3.4.21.107" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 11555295, 12823817, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 11555295, 12823817, 24362423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound serine protease Do, quality control protease and chaperone (heat-shock protein)" /protein_id="NP_389173.2" /db_xref="EnsemblGenomes-Gn:BSU12900" /db_xref="EnsemblGenomes-Tr:CAB13147" /db_xref="GOA:O34358" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG12608" /db_xref="UniProtKB/Swiss-Prot:O34358" /translation="MDNYRDENRTKGNENEVFLTKENDQSASYSARNVIHDQEKKKRG FGWFRPLLGGVIGGSLALGIYTFTPLGDHDSQDTAKQSSSQQQTQSVTATSTSSESKK SSSSSSAFKSEDSSKISDMVEDLSPAIVGITNLQAQSNSSLFGSSSSDSSEDTESGSG SGVIFKKENGKAYIITNNHVVEGASSLKVSLYDGTEVTAKLVGSDSLTDLAVLQISDD HVTKVANFGDSSDLRTGETVIAIGDPLGKDLSRTVTQGIVSGVDRTVSMSTSAGETSI NVIQTDAAINPGNSGGPLLNTDGKIVGINSMKISEDDVEGIGFAIPSNDVKPIAEELL SKGQIERPYIGVSMLDLEQVPQNYQEGTLGLFGSQLNKGVYIREVASGSPAEKAGLKA EDIIIGLKGKEIDTGSELRNILYKDAKIGDTVEVKILRNGKEMTKKIKLDQKEEKTS* " /label="htrA CDS" gene complement(1239131..1240480) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /label="htrA gene" downshifts complement(1239145) /Source="Nicolas_upshifts" /id="D705" /incds=0 /nref=198 /ntot=244 /MaxReadThrough="2.95586" /MaxDrop="5.35972" /score="30.7234179" /energy="-19.9" /TU="NA" /idTUdmin="U1044" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1240520..1240527 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-35" promotor_-10 complement(1240532..1240551) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1240540 /Source="Nicolas_upshifts" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="upshifts" promotor_-10 1240542..1240561 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-10" upshifts complement(1240550) /Source="Nicolas_upshifts" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1240552..1240634) /Source="Nicolas_S_feature" /locus_tag="new_1359357_1359439_c" /HighExp="Etha, dia5, S8, S6, T2.0H, T3.30H, dia15, T5.0H, BC, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.682" /TUlongSig="NA" /TUlongPSig="NA" /label="S463" promotor_-35 complement(1240562..1240569) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1240591..1240597 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1240612..1240631 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1240615 /Source="Nicolas_upshifts" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1240617..1240636) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1240634) /Source="Nicolas_upshifts" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1240649..1241467 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /EC_number="1.5.1.2" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redundant pyrroline-5-carboxylate reductase" /protein_id="NP_389174.1" /db_xref="EnsemblGenomes-Gn:BSU12910" /db_xref="EnsemblGenomes-Tr:CAB13148" /db_xref="GOA:Q00777" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10841" /db_xref="UniProtKB/Swiss-Prot:Q00777" /translation="MEQIGLIGYGSMADMIARQLLKHEQIKENELFIETRTKGERLRA LMSDYPNVSADPLENWANTCQLILICVPPLHVIETMRRLYPYVNRNTHIVSIAAGVPL RLLEAETEAGISRVIPAITSEAEAGISLVVHSEALAAEKKERLNELLSVFSRVREIKE SNLDVASNLTSSAPGFIAAIFEELALSAVRNSSLSKEEAFDFLIHSLYGTGKMLIEKN MSFEETLERVATKGGITGEGAEVIHASVPDVFDEVFERTLRKYELLTEQVGKQT*" /label="proCC CDS" gene 1240649..1241467 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /label="proCC gene" promotor_-35 complement(1240652..1240655) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1241445 /Source="Nicolas_upshifts" /id="D706" /incds=0 /nref=90 /ntot=220 /MaxReadThrough="1.3818" /MaxDrop="4.43155" /score="-5.08770006" /energy="-5.3" /TU="NA" /idTUdmin="U1045" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1241524..1241531 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1241546..1241565 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1241550 /Source="Nicolas_upshifts" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1241596..1242420 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11069674, 11473256, 19340926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069674, 11473256, 19340926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-aminopeptidase" /protein_id="NP_389175.2" /db_xref="EnsemblGenomes-Gn:BSU12920" /db_xref="EnsemblGenomes-Tr:CAB13149" /db_xref="GOA:P26902" /db_xref="InterPro:IPR007035" /db_xref="InterPro:IPR027476" /db_xref="InterPro:IPR033824" /db_xref="InterPro:IPR036177" /db_xref="PDB:1HI9" /db_xref="SubtiList:BG10842" /db_xref="UniProtKB/Swiss-Prot:P26902" /translation="MKLYMSVDMEGISGLPDDTFVDSGKRNYERGRLIMTEEANYCIA EAFNSGCTEVLVNDSHSKMNNLMVEKLHPEADLISGDVKPFSMVEGLDDTFRGALFLG YHARASTPGVMSHSMIFGVRHFYINDRPVGELGLNAYVAGYYDVPVLMVAGDDRAAKE AEELIPNVTTAAVKQTISRSAVKCLSPAKAGRLLTEKTAFALQNKDKVKPLTPPDRPV LSIEFANYGQAEWANLMPGTEIKTGTTTVQFQAKDMLEAYQAMLVMTELAMRTSFC*" /label="dppA CDS" gene 1241596..1242420 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /label="dppA gene" CDS 1242437..1243363 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389176.1" /db_xref="EnsemblGenomes-Gn:BSU12930" /db_xref="EnsemblGenomes-Tr:CAB13150" /db_xref="GOA:P26903" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10843" /db_xref="UniProtKB/Swiss-Prot:P26903" /translation="MARYMIKRFWAMAATILVITTLTFVLMKVIPGSPFNEERGTNEA VQKNLEAYYHLDDPLIFQYIFYLKSIITFDFGPSIKKPSDSVNDMLERGFPVSFELGM TAIVIAVISGLVLGVIAALRRNGFLDYAAMSLAVLGISIPNFILATLLIQQFAVNLKL FPAATWTSPIHMVLPTAALAVGPMAIIARLTRSSMVEVLTQDYIRTAKAKGLSPFKII VKHALRNALMPVITVLGTLVASILTGSFVIEKIFAIPGMGKYFVESINQRDYPVIMGT TVFYSVILIIMLFLVDLAYGLLDPRIKLHKKG*" /label="dppB CDS" gene 1242437..1243363 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /label="dppB gene" CDS 1243369..1244331 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389177.1" /db_xref="EnsemblGenomes-Gn:BSU12940" /db_xref="EnsemblGenomes-Tr:CAB13151" /db_xref="GOA:P26904" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10844" /db_xref="UniProtKB/Swiss-Prot:P26904" /translation="MNLPVQTDERQPEQHNQVPDEWFVLNQEKNREADSVKRPSLSYT QDAWRRLKKNKLAMAGLFILLFLFVMAVIGPFLSPHSVVRQSLTEQNLPPSADHWFGT DELGRDVFTRTWYGARISLFVGVMAALIDFLIGVIYGGVAGYKGGRIDSIMMRIIEVL YGLPYLLVVILLMVLMGPGLGTIIVALTVTGWVGMARIVRGQVLQIKNYEYVLASKTF GAKTFRIIRKNLLPNTMGAIIVQMTLTVPAAIFAESFLSFLGLGIQAPFASWGVMAND GLPTILSGHWWRLFFPAFFISLTMYAFNVLGDGLQDALDPKLRR*" /label="dppC CDS" gene 1243369..1244331 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /label="dppC gene" promotor_-35 1244063..1244068 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1244084..1244102 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1244085 /Source="Nicolas_upshifts" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1244336..1245343 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7536291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7536291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (ATP-binding subunit)" /protein_id="NP_389178.1" /db_xref="EnsemblGenomes-Gn:BSU12950" /db_xref="EnsemblGenomes-Tr:CAB13152" /db_xref="GOA:P26905" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10845" /db_xref="UniProtKB/Swiss-Prot:P26905" /translation="MEKVLSVQNLHVSFTTYGGTVQAVRGVSFDLYKGETFAIVGESG CGKSVTSQSIMGLLPPYSAKVTDGRILFKNKDLCRLSDKEMRGIRGADISMIFQDPMT ALNPTLTVGDQLGEALLRHKKMSKKAARKEVLSMLSLVGIPDPGERLKQYPHQFSGGM RQRIVIAMALICEPDILIADEPTTALDVTIQAQILELFKEIQRKTDVSVILITHDLGV VAQVADRVAVMYAGKMAEIGTRKDIFYQPQHPYTKGLLGSVPRLDLNGAELTPIDGTP PDLFSPPPGCPFAARCPNRMVVCDRVYPGQTIRSDSHTVNCWLQDQRAEHAVLSGDAK D*" /label="dppD CDS" gene 1244336..1245343 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /label="dppD gene" CDS 1245346..1246995 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7783641, 8793880, 11390694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783641, 8793880, 11390694; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (dipeptide-binding lipoprotein)" /protein_id="NP_389179.2" /db_xref="EnsemblGenomes-Gn:BSU12960" /db_xref="EnsemblGenomes-Tr:CAB13153" /db_xref="GOA:P26906" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10846" /db_xref="UniProtKB/Swiss-Prot:P26906" /translation="MKRGKRMKRVKKLWGMGLALGLSFALMGCTANEQAGKEGSHDKA KTSGEKVLYVNNENEPTSFDPPIGFNNVSWQPLNNIMEGLTRLGKDHEPEPAMAEKWS VSKDNKTYTFTIRENAKWTNGDPVTAGDFEYAWKRMLDPKKGASSAFLGYFIEGGEAY NSGKGKKDDVKVTAKDDRTLEVTLEAPQKYFLSVVSNPAYFPVNEKVDKDNPKWFAES DTFVGNGPFKLTEWKHDDSITMEKSDTYWDKDTVKLDKVKWAMVSDRNTDYQMFQSGE LDTAYVPAELSDQLLDQDNVNIVDQAGLYFYRFNVNMEPFQNENIRKAFAMAVDQEEI VKYVTKNNEKPAHAFVSPGFTQPDGKDFREAGGDLIKPNESKAKQLLEKGMKEENYNK LPAITLTYSTKPEHKKIAEAIQQKLKNSLGVDVKLANMEWNVFLEDQKALKFQFSQSS FLPDYADPISFLEAFQTGNSMNRTGWANKEYDQLIKQAKNEADEKTRFSLMHQAEELL INEAPIIPVYFYNQVHLQNEQVKGIVRHPVGYIDLKWADKN*" /label="dppE CDS" gene 1245346..1246995 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /label="dppE gene" downshifts 1246989 /Source="Nicolas_upshifts" /id="D707" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="6.73127" /MaxDrop="3.5888" /score="22.838155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-4469" /isTUend="FALSE" /label="downshifts" CDS 1247083..1248042 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /EC_number="3.4.17.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10428950, 15101989, 18535144, 20944232, 24123814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="muropeptide L,D-carboxypeptidase" /protein_id="NP_389180.2" /db_xref="EnsemblGenomes-Gn:BSU12970" /db_xref="EnsemblGenomes-Tr:CAB13154" /db_xref="GOA:O34851" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13231" /db_xref="UniProtKB/Swiss-Prot:O34851" /translation="MKGVFSLNYKPKALNKGDTVGVIAPASPPDPKKLDTALLFLEEL GLQVKLGKALKNQHGYLAGQDDERLADLHEMFRDDEVKAVLCACGGFGTGRIAAGIDF SLIRKHPKIFWGYSDITFLHTAIHQNTGLVTFHGPMLSTDIGLDDVHPLTKASYKQLF QETEFTYTEELSPLTELVPGKAEGELVGGNLSLLTSTLGTPFEIDTRGKLLFIEDIDE EPYQIDRMLNQLKMGGKLTDAAGILVCDFHNCVPVKREKSLSLEQVLEDYIISAGRPA LRGFKIGHCSPSIAVPIGAKAAMNTAEKTAVIEAGVSEGALKT*" /label="ldcA CDS" gene 1247083..1248042 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /label="ldcA gene" CDS 1248039..1249139 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /EC_number="5.1.1.20" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11747447, 11747448, 15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11747447, 11747448, 15101989; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-Ala-D/L-Glu epimerase" /protein_id="NP_389181.1" /db_xref="EnsemblGenomes-Gn:BSU12980" /db_xref="EnsemblGenomes-Tr:CAB13155" /db_xref="GOA:O34508" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:1JPM" /db_xref="PDB:1TKK" /db_xref="SubtiList:BG13232" /db_xref="UniProtKB/Swiss-Prot:O34508" /translation="MKIIRIETSRIAVPLTKPFKTALRTVYTAESVIVRITYDSGAVG WGEAPPTLVITGDSMDSIESAIHHVLKPALLGKSLAGYEAILHDIQHLLTGNMSAKAA VEMALYDGWAQMCGLPLYQMLGGYRDTLETDYTVSVNSPEEMAADAENYLKQGFQTLK IKVGKDDIATDIARIQEIRKRVGSAVKLRLDANQGWRPKEAVTAIRKMEDAGLGIELV EQPVHKDDLAGLKKVTDATDTPIMADESVFTPRQAFEVLQTRSADLINIKLMKAGGIS GAEKINAMAEACGVECMVGSMIETKLGITAAAHFAASKRNITRFDFDAPLMLKTDVFN GGITYSGSTISMPGKPGLGIIGAALLKGEKEQ*" /label="aeeB CDS" gene 1248039..1249139 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /label="aeeB gene" CDS 1249136..1250026 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989, 20944232" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 20944232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamyl-L-diaminoacid endopeptidase" /protein_id="NP_389182.2" /db_xref="EnsemblGenomes-Gn:BSU12990" /db_xref="EnsemblGenomes-Tr:CAB13156" /db_xref="GOA:O35010" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG13233" /db_xref="UniProtKB/Swiss-Prot:O35010" /translation="MMHTVISAVANIWTAPDSPRPSDQFMLQPTVMIRDWLERMTYDE RLGLCTDNVIQTQVLFGEKVLVTAEQGEWVSVIVPSQPSRKDPRGYPGWMKKYQLEKT KPIHTQHDVMISKPAAFLYRSNGEKEIELSFLTVLPLIAKENGYFKVSTVFGERFVRQ SDAVPVSQQKGTAEDIIQTGAFFLGLPYLWGGISGFGFDCSGFMYSIFKANGYSIPRD AGDQAKAGKGVPLDDMKAGDLLFFAYEEGKGAIHHVGLYVGGGKMLHSPKTGKSIEIL TLTETIYEKELCAVRRCFSE*" /label="eepC CDS" gene 1249136..1250026 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /label="eepC gene" CDS 1250039..1251028 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cell wall oligopeptide ABC transporter (ATP binding protein)" /protein_id="NP_389183.2" /db_xref="EnsemblGenomes-Gn:BSU13000" /db_xref="EnsemblGenomes-Tr:CAB13157" /db_xref="GOA:C0SP98" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13234" /db_xref="UniProtKB/Swiss-Prot:C0SP98" /translation="MRRLPLLEVSQLKMHFDAGKKRTVKAVDGVTFQIREGETFGLVG ESGCGKSTLGRVLMRLYQPTEGSVTYRGTNLHALSEKEQFAFNRKLQMIFQDPYASLN PRMTVREIILEPMEIHNLYNTHKARLLVVDELLEAVGLHPDFGSRYPHEFSGGQRQRI GIARALSLNPEFIVADEPISALDVSVQAQVVNLLKRLQKEKGLTFLFIAHDLSMVKHI SDRIGVMYLGHMMEITESGTLYREPLHPYTKALLSSIPIPDPELEDKRERILLKGELP SPVNPPSGCVFRTRCPEAMPECGESRPQLQEIEPGRFVACHLYRNAETKEKVR*" /label="ykfD CDS" gene 1250039..1251028 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /label="ykfD gene" S_feature complement(1250322..1251049) /Source="Nicolas_S_feature" /locus_tag="new_1369127_1369854_c" /HighExp="Etha, S7, Gly, M40t90, C30, H2O2, M0t90, dia15, T1.0H, S8" /AntisenseName="ykfD" /AntisenseCor="-6.3474114158352593E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S464" downshifts 1251018 /Source="Nicolas_upshifts" /id="D708" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="5.08319" /MaxDrop="3.1399" /score="-3.10371155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" S_feature 1251063..1252231 /Source="Nicolas_S_feature" /locus_tag="new_1369868_1371036" /HighExp="T3.30H, T4.0H, T3.0H, T5.0H, T2.30H, T2.0H, S1, M9-stat, T1.30H, HiOs" /AntisenseName="ykgB" /AntisenseCor="-0.33524952291190102" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S465" CDS complement(1251071..1252120) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /EC_number="3.1.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22960854, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconolactonase" /protein_id="NP_389184.1" /db_xref="EnsemblGenomes-Gn:BSU13010" /db_xref="EnsemblGenomes-Tr:CAB13158" /db_xref="GOA:O34499" /db_xref="InterPro:IPR011048" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019405" /db_xref="SubtiList:BG13236" /db_xref="UniProtKB/Swiss-Prot:O34499" /translation="MTKYIGYVGTYTKGGSEGIYSFELDTEKKALSEPKLAAKLGNPT YVATNKNNTILYSIEKADGQGGVAAYQIDKNSGELTFLNHQLIDGPSPCHVSVDDQNQ FVLTANYHSGKVHVFPVQEDGSLQSPVSEAAHTGKGPHERQEKPHTHYAGFTPEHNYV VAVDLGIDKLYTYKLKDGVLTESGSHSFAPGAGPRHIAFHPKEKYAYVMTELSNEVIA LEYNPTAGEFREIQVVSAIPDDFTDNSQGSAIHVTQDGRFVYVANRGHDSIAVFEVNQ YSGELAFVERVSTEGNWPRDFVFDPTEGFLVASNEETGNLVLFERDKETGRLTLLPST VSVPYPVCVKFLHQV*" /label="pgl CDS" gene complement(1251071..1252120) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /label="pgl gene" downshifts complement(1251094) /Source="Nicolas_upshifts" /id="D709" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="5.12776" /MaxDrop="6.0668" /score="24.6986564" /energy="-15.6" /TU="U1050" /idTUdmin="U1049" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1252147..1252166) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1252158) /Source="Nicolas_upshifts" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1252181..1252188) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1252210..1253070) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /EC_number="3.5.3.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27258038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N(G),N(G)-dimethylarginine dimethylaminohydrolase" /protein_id="NP_389185.2" /db_xref="EnsemblGenomes-Gn:BSU13020" /db_xref="EnsemblGenomes-Tr:CAB13159" /db_xref="GOA:O34497" /db_xref="InterPro:IPR033199" /db_xref="SubtiList:BG13235" /db_xref="UniProtKB/Swiss-Prot:O34497" /translation="MDVSIPKSQHKTVCRTEYGTLQKVILCKPEHMTIKDVINETQKH FEDDNIHVKTANDQHSRLVEALRSHNVEVVLLPVRDGLPEQVFTRDIGFVIGEKAFLS SMTEPIRQGEEAVIKDFFHSQGISYTRMLDTSIEGGDVIIDDDIVYVGISQRTDISAI GQLEEALPEYTIVPVKLHEKFLHLDCVFNIISESEALIYSQAIEPDAADMLAKRYDLI EVPEDEQFTLGTNVLSIGKKTIISLPGNRHVNQQLSKRGYHIIEIDLSEIIKSGGSFR CCTMPLIRGE*" /label="ddaH CDS" gene complement(1252210..1253070) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /label="ddaH gene" promotor_-10 complement(1253095..1253113) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1253112) /Source="Nicolas_upshifts" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1253129..1253135) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1253144..1253151 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1253165..1253184 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1253172 /Source="Nicolas_upshifts" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="upshifts" CDS 1253230..1253748 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /EC_number="3.1.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12426338, 18247525, 24623648, 24722906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acyl-CoA thioesterase" /protein_id="NP_389186.2" /db_xref="EnsemblGenomes-Gn:BSU13030" /db_xref="EnsemblGenomes-Tr:CAB13160" /db_xref="GOA:P49851" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR033120" /db_xref="SubtiList:BG11417" /db_xref="UniProtKB/Swiss-Prot:P49851" /translation="METPETRFCKESKVVKTSRVFPLDTNNHNTLFGGKLMSYIDDIA SISAARHCRRETVTASMDSVDFLKPIGQKDSVCLESYVTWVGTSSMEVFVKVIKEHLM TGERELAATSFLTFVALDSNGKPVPVPRVVPETEEEIMLHNTAVQRANERKNRKRHSQ ALANALGTDKPW*" /label="ykhA CDS" gene 1253230..1253748 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /label="ykhA gene" downshifts 1253739 /Source="Nicolas_upshifts" /id="D710" /incds=0 /nref=34 /ntot=265 /MaxReadThrough="4.66856" /MaxDrop="4.77681" /score="24.0889455" /energy="-10.9" /TU="U1051" /idTUdmin="U1051" /TUdmin="-1436" /isTUend="FALSE" /label="downshifts" promotor_-35 1253813..1253819 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-35" S_feature 1253831..1253937 /Source="Nicolas_S_feature" /locus_tag="new_1372636_1372742" /HighExp="Etha, S5, S6, S8, nit, S7, ferm, S4, dia15, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S466" upshifts 1253831 /Source="Nicolas_upshifts" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="upshifts" promotor_-10 1253833..1253844 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-10" promotor_-35 1253912..1253915 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1253931..1253950 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1253939 /Source="Nicolas_upshifts" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1253987..1255186 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044; Product type c: carrier" /codon_start=1 /transl_table=11 /product="flavohemoglobin" /protein_id="NP_389187.1" /db_xref="EnsemblGenomes-Gn:BSU13040" /db_xref="EnsemblGenomes-Tr:CAB13161" /db_xref="GOA:P49852" /db_xref="InterPro:IPR000971" /db_xref="InterPro:IPR001221" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR008333" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023950" /db_xref="SubtiList:BG11418" /db_xref="UniProtKB/Swiss-Prot:P49852" /translation="MLDNKTIEIIKSTVPVLQQHGETITGRFYDRMFQDHPELLNIFN QTNQKKKTQRTALANAVIAAAANIDQLGNIIPVVKQIGHKHRSIGIKPEHYPIVGKYL LIAIKDVLGDAATPDIMQAWEKAYGVIADAFIGIEKDMYEQAEEQAGGWKEYKPFVIA KKERESKEITSFYLKPEDSKPLPEFQAGQYISIKVRIPDSEYTHIRQYSLSDMPGKDY YRISVKKDGVVSSYLHDGLQEGDSIEISAPAGDFVLDHASQKDLVLISAGVGITPMIS MLKTSVSKQPERQILFIHAAKNSEYHALRHEVEEAAKHSAVKTAFVYREPTEEDRAGD LHFHEGQIDQQFLKELIANTDADYYICGSPSFITAMHKLVSELGSAPESIHYELFGPQ LSLAQSV*" /label="hmpA CDS" gene 1253987..1255186 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /label="hmpA gene" downshifts 1255175 /Source="Nicolas_upshifts" /id="D711" /incds=0 /nref=10 /ntot=59 /MaxReadThrough="6.06442" /MaxDrop="4.19301" /score="11.2868967" /energy="-9.3" /TU="U1053" /idTUdmin="U1051" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1255220..1255591 /Source="Nicolas_S_feature" /locus_tag="new_1374025_1374396" /HighExp="nit, B36, B60, Etha, BI, M40t90, LBGtran, M0t90, BT, S6" /AntisenseName="ykzH" /AntisenseCor="7.6554747052539299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="SigGF" /TUlongPSig="0.998" /label="S467" CDS complement(1255263..1255487) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389188.1" /db_xref="EnsemblGenomes-Gn:BSU13050" /db_xref="EnsemblGenomes-Tr:CAB13162" /db_xref="SubtiList:BG13336" /db_xref="UniProtKB/Swiss-Prot:O31653" /translation="MKNQKSNTLWPFDLPLAPQPEGYQQQTIDRLAGLELRMKQLIRA IEVNNELLRTMQEQQNRVCTNGSGSVIVRM*" /label="ykzH CDS" gene complement(1255263..1255487) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /label="ykzH gene" promotor_-35 1255567..1255573 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1255587..1255598 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1255593 /Source="Nicolas_upshifts" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1255632..1256363 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389189.1" /db_xref="EnsemblGenomes-Gn:BSU13060" /db_xref="EnsemblGenomes-Tr:CAB13163" /db_xref="GOA:P49853" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG11419" /db_xref="UniProtKB/Swiss-Prot:P49853" /translation="MLWMVWVFLLKPVIVFSIAYILFRLAGKKAVSQMNNFDLLLTFA IGTIISEPILTSKLPMSIYYAGAFLVLYLIMSKLSLSNKWRWLLVVSPTVLIRNGDID ERGLRKERLTVNELLGKLREKGYADPADIDLAIIEETGEVSVIPKEEARAVQVRDLNM EAERNFIPIPLILDGEILDHNLKYLQKNRSWLFEKLEEKGYSPKLLSSIILGTMNARG DISLDLNTANEPQHDPYLYKPGNNN*" /label="ykjA CDS" gene 1255632..1256363 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /label="ykjA gene" downshifts 1256341 /Source="Nicolas_upshifts" /id="D712" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="2.84532" /MaxDrop="4.44655" /score="17.2468985" /energy="-7.2" /TU="U1053" /idTUdmin="U1054" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1256402..1256410 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1256421..1256439 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1256429 /Source="Nicolas_upshifts" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1256455..1256982 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389190.1" /db_xref="EnsemblGenomes-Gn:BSU13070" /db_xref="EnsemblGenomes-Tr:CAB13164" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG11420" /db_xref="UniProtKB/Swiss-Prot:P49854" /translation="MKDLSIRNDMAPTVSLLYSAVEENSLRLASIVSHMTHSELYYKG RCQTKNSTAQLLHHITNVDIRWVWRIKENRIPDHIEQAYGPMTDESGRLPEPVNQPDL DELLKRHQHVVEKLKSVCFTLTENALNQPLSFEGDTATIRWGIWHMADHNRYHQAHIE ALKKEWKQDVAKYER*" /label="ykkA CDS" gene 1256455..1256982 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /label="ykkA gene" CDS 1256972..1257490 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389191.1" /db_xref="EnsemblGenomes-Gn:BSU13080" /db_xref="EnsemblGenomes-Tr:CAB13165" /db_xref="GOA:P49855" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11421" /db_xref="UniProtKB/Swiss-Prot:P49855" /translation="MNAKTKLVTDRIRLRCMEDRDQATLFGLLFNDPDVMTYYSGLKD KRQTREWVNWNQRNEKGYGVSLWIAEDKRTGEFLGQCGIVPQQIENQTVMEIGYMFAR RHWGNGYAQEAARACLDYGFNERQFGKMAALIDPGNKASIRVAEKIGMHYSKTIRKWN KPIAVYERKSYN*" /label="ykkB CDS" gene 1256972..1257490 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /label="ykkB gene" promotor_-35 1257484..1257491 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-35" promotor_-10 1257505..1257524 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-10" upshifts 1257508 /Source="Nicolas_upshifts" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="upshifts" misc_RNA 1257523..1257634 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /product="guanidine-sensing riboswitch (binds free guanidinium)" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17908319, 21317561, 27989440, 28001368, 28017522, 28107646, 28212758; Product type n: RNA" /label="gdwA RNA" gene 1257523..1257634 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /label="gdwA gene" downshifts 1257597 /Source="Nicolas_upshifts" /id="D713" /incds=0 /nref=205 /ntot=246 /MaxReadThrough="3.70824" /MaxDrop="6.58389" /score="30.3456563" /energy="-18.5" /TU="U1056" /idTUdmin="U1056" /TUdmin="-789" /isTUend="FALSE" /label="downshifts" CDS 1257712..1258050 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389192.1" /db_xref="EnsemblGenomes-Gn:BSU13090" /db_xref="EnsemblGenomes-Tr:CAB13166" /db_xref="GOA:P49856" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11422" /db_xref="UniProtKB/Swiss-Prot:P49856" /translation="MKWGLVVLAAVFEVVWVIGLKHADSALTWSGTAIGIIFSFYLLM KATHSLPVGTVYAVFTGLGTAGTVLSEIVLFHEPVGWPKLLLIGVLLIGVIGLKLVTQ DETEEKGGEA*" /label="gdnC CDS" gene 1257712..1258050 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /label="gdnC gene" CDS 1258050..1258367 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389193.1" /db_xref="EnsemblGenomes-Gn:BSU13100" /db_xref="EnsemblGenomes-Tr:CAB13167" /db_xref="GOA:P49857" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11423" /db_xref="UniProtKB/Swiss-Prot:P49857" /translation="MLHWISLLCAGCLEMAGVALMNQYAKEKSVKWVLLIIVGFAASF SLLSYAMETTPMGTAYAVWTGIGTAGGALIGILFYKEQKDAKRIFFIALILCSAVGLK ILS*" /label="gdnD CDS" gene 1258050..1258367 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /label="gdnD gene" promotor_-35 1258367..1258370 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1258386..1258405 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1258398 /Source="Nicolas_upshifts" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1258438..1259340 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /EC_number="3.5.1.10" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8226647, 24108189; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formyltetrahydrofolate hydrolase" /protein_id="NP_389194.2" /db_xref="EnsemblGenomes-Gn:BSU13110" /db_xref="EnsemblGenomes-Tr:CAB13168" /db_xref="GOA:O34990" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004810" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG13237" /db_xref="UniProtKB/Swiss-Prot:O34990" /translation="MKSYMTQRLDEYRDGNEDKGRLLVSCPDQPGIVSAVSAFLFEHG ANIIESNQYTTDPEGGRFFLRIEFDCAGIREKKSSLQAAFASVAEKFDMTWSLTLASE LKRVAIFVSKELHCLHELIWEWQTGNLMAEIAVVISNHEEARELVERLNIPFHYMKAN KDIRAEVEKKQLELLEQYDVDVIVLARYMQILTPDFVSAHPNRIINIHHSFLPAFIGA NPYKRAYERGVKLIGATSHYVTNDLDEGPIIEQDIERVDHRDNAEALKNIGRTIERSV LARAVKWHLEDRVIVHENKTIVFN*" /label="purU CDS" gene 1258438..1259340 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /label="purU gene" downshifts 1259331 /Source="Nicolas_upshifts" /id="D714" /incds=0 /nref=91 /ntot=226 /MaxReadThrough="3.55628" /MaxDrop="5.02155" /score="16.8011006" /energy="-13.1" /TU="U1057" /idTUdmin="U1056" /TUdmin=945 /isTUend="FALSE" /label="downshifts" promotor_-35 1259387..1259393 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1259399 /Source="Nicolas_upshifts" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1259407..1259426 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1259428..1259638 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /product="T-box riboswitch specific of proline tRNA" /experiment="publication(s) with functional evidences, PMID:11917026, 12749771, 19932103, 21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11917026, 12749771, 19932103, 21233158; Product type n: RNA" /function="16.3: Control" /label="pswB RNA" gene 1259428..1259638 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /label="pswB gene" downshifts 1259596 /Source="Nicolas_upshifts" /id="D715" /incds=0 /nref=4 /ntot=52 /MaxReadThrough="6.91996" /MaxDrop="3.8361" /score="29.5878921" /energy="-17.6" /TU="U1057,U1058" /idTUdmin="U1056" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1259691..1260788 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /EC_number="2.7.2.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21233158, 21784929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21233158, 21784929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389195.2" /db_xref="EnsemblGenomes-Gn:BSU13120" /db_xref="EnsemblGenomes-Tr:CAB13169" /db_xref="GOA:P39820" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10963" /db_xref="UniProtKB/Swiss-Prot:P39820" /translation="MKKQRIVVKIGSSSLTNSKGSIDEAKIREHVQAISVLKKAGHEM ILITSGAVAAGFSSLGYPSRPVTIKGKQAAAAVGQTLLMQQYMNQFKQYSLTPGQILL TRNDFSKRERYRNAYATIMELLERGVIPIINENDSTSVEELTFGDNDMLSALVSGLIH ADQLMILTDINGLYDANPNENPEAKRFDYLPEITPELLGYAGSAGSKVGTGGMKSKLL ATQTALSLGVKVFIGTGSGEQKLADILDGRGDGTYIGDKELSSVNNTRQWIQFHSPIS GEIIIDAGAEEAMIHNGSSLLPAGVVGVNGSFPKGAVVEVRGPGGVIGKGQTHYSSEE IMEAKGKRSDELDFEKTFEVIHRNDWVNVKD*" /label="proB CDS" gene 1259691..1260788 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /label="proB gene" promotor_-35 1259878..1259880 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1259882..1259886 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1259882 /Source="Nicolas_upshifts" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1260800..1262047 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /EC_number="1.2.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21784929, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21784929, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-glutamyl phosphate reductase" /protein_id="NP_389196.2" /db_xref="EnsemblGenomes-Gn:BSU13130" /db_xref="EnsemblGenomes-Tr:CAB13170" /db_xref="GOA:P39821" /db_xref="InterPro:IPR000965" /db_xref="InterPro:IPR012134" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR020593" /db_xref="SubtiList:BG10964" /db_xref="UniProtKB/Swiss-Prot:P39821" /translation="MSEVSVKAKLAKEAAAEMIMKTTAEKDEALSLIANGLRKELDFL LAENAKDIVNGKENGLTPDIIDRLSLDEKRIRDIADAVELLIDLADPIGDSLETIEKE NGLFIEKIRVPLGVVGMIYEARPNVTVDAATLCLKTGNAVVLRGSSSAIHSNKALVSV IYRALEQSALPIHAVQLIEDTSRETAKELFTLNDGLDVLIPRGGKKLIDLVVRESTVP VLETGAGNCHIFIDETAKPQMAEKVVVNAKTQRPSVCNAIESLLIHKAWARQHGKELL DQLENAGVEIRGDELVCELHPSSKQASKEDWETEFLAPVLSVKTVENVQEAVKHIQQY GTNHSEAILTENDKNAVYFQTAVDAAAVYHNASTRFTDGFEFGYGAEIGISTQKLHAR GPMGLPALTSTKYIIKGTGQIRE*" /label="proA CDS" gene 1260800..1262047 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /label="proA gene" downshifts 1262038 /Source="Nicolas_upshifts" /id="D716" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="4.1607" /MaxDrop="6.017" /score="11.118012" /energy="-11" /TU="U1058" /idTUdmin="U1059" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1262109..1262116 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1262131..1262150 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1262140 /Source="Nicolas_upshifts" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1262173..1262598 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11418552, 17502599, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418552, 17502599, 21749987, 24184231; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin" /protein_id="NP_389197.1" /db_xref="EnsemblGenomes-Gn:BSU13140" /db_xref="EnsemblGenomes-Tr:CAB13171" /db_xref="GOA:O34762" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13238" /db_xref="UniProtKB/Swiss-Prot:O34762" /translation="MSQPLFTATVSAVGGREGKVISSDRVLELDVAMPGTPRAKKLEK ATNPEQLFAAGYAACFDSALQLVARTERVKVETEVTANVSLLKDEADQGYKLGVTLQV KGEGVSASELEALVKKAHGVCPYSKATSGNIDVTLEVAE*" /label="ohrA CDS" gene 1262173..1262598 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /label="ohrA gene" downshifts 1262587 /Source="Nicolas_upshifts" /id="D717" /incds=0 /nref=57 /ntot=174 /MaxReadThrough="0.0429100000000009" /MaxDrop="3.90314" /score="30.9245751" /energy="-16.6" /TU="NA" /idTUdmin="U1060" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1262629..1263072) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11983871, 17502599, 18363800, 20094649, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11983871, 17502599, 18363800, 20094649, 21749987, 24184231; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator sensing organic peroxides" /protein_id="NP_389198.1" /db_xref="EnsemblGenomes-Gn:BSU13150" /db_xref="EnsemblGenomes-Tr:CAB13172" /db_xref="GOA:O34777" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1Z91" /db_xref="PDB:1Z9C" /db_xref="SubtiList:BG13239" /db_xref="UniProtKB/Swiss-Prot:O34777" /translation="MENKFDHMKLENQLCFLLYASSREMTKQYKPLLDKLNITYPQYL ALLLLWEHETLTVKKMGEQLYLDSGTLTPMLKRMEQQGLITRKRSEEDERSVLISLTE DGALLKEKAVDIPGTILGLSKQSGEDLKQLKSALYTLLETLHQKN*" /label="ohrR CDS" gene complement(1262629..1263072) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /label="ohrR gene" downshifts complement(1262663) /Source="Nicolas_upshifts" /id="D718" /incds=0 /nref=105 /ntot=232 /MaxReadThrough="-0.17111" /MaxDrop="4.73026" /score="34.7008532" /energy="-16.6" /TU="NA" /idTUdmin="U1061" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1263099..1263118) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1263105) /Source="Nicolas_upshifts" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1263133..1263136) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1263154..1263160 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1263174..1263192 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1263180 /Source="Nicolas_upshifts" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="upshifts" CDS 1263215..1263625 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9696771, 11418552, 18084074" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696771, 11418552, 18084074; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="organic hydroperoxide resistance reductase B" /protein_id="NP_389199.1" /db_xref="EnsemblGenomes-Gn:BSU13160" /db_xref="EnsemblGenomes-Tr:CAB13173" /db_xref="GOA:P80242" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="PDB:2BJO" /db_xref="SubtiList:BG19021" /db_xref="UniProtKB/Swiss-Prot:P80242" /translation="MALFTAKVTARGGRAGHITSDDGVLDFDIVMPNAKKEGQTGTNP EQLFAAGYAACFGGALEHVAKEQNIEIDSEIEGQVSLMKDESDGGFKIGVTLVVNTKD LDREKAQELVNAAHEFCPYSKATRGNVDVKLELK*" /label="ohrB CDS" gene 1263215..1263625 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /label="ohrB gene" downshifts 1263603 /Source="Nicolas_upshifts" /id="D719" /incds=0 /nref=7 /ntot=145 /MaxReadThrough="8.17185" /MaxDrop="4.0663" /score="17.6512157" /energy="-12.1" /TU="U1062" /idTUdmin="U1062" /TUdmin="-855" /isTUend="FALSE" /label="downshifts" CDS 1263652..1263822 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097717.1" /db_xref="EnsemblGenomes-Gn:BSU13169" /db_xref="EnsemblGenomes-Tr:CAX52607" /db_xref="UniProtKB/Swiss-Prot:C0H400" /translation="MFFGVGHAGRAQIYDKTSEKRLKHAFKPKVTDEAGGWHGVCRAE LRVYAVLYLHRA*" /label="ykzN CDS" gene 1263652..1263822 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /label="ykzN gene" S_feature 1263823..1264500 /Source="Nicolas_S_feature" /locus_tag="new_1382628_1383305" /HighExp="Etha, Salt, M9-stat, Sw, B60, LPhT, B36, Heat, Gly, BC" /AntisenseName="guaD" /AntisenseCor="-5.7732597431508298E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S468" CDS complement(1263872..1264342) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /EC_number="3.5.4.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11101664, 15180998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101664, 15180998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanine deaminase" /protein_id="NP_389200.1" /db_xref="EnsemblGenomes-Gn:BSU13170" /db_xref="EnsemblGenomes-Tr:CAB13174" /db_xref="GOA:O34598" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1TIY" /db_xref="PDB:1WKQ" /db_xref="SubtiList:BG13240" /db_xref="UniProtKB/Swiss-Prot:O34598" /translation="MNHETFLKRAVTLACEGVNAGIGGPFGAVIVKDGAIIAEGQNNV TTSNDPTAHAEVTAIRKACKVLGAYQLDDCILYTSCEPCPMCLGAIYWARPKAVFYAA EHTDAAEAGFDDSFIYKEIDKPAEERTIPFYQVTLTEHLSPFQAWRNFANKKEY*" /label="guaN CDS" gene complement(1263872..1264342) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /label="guaN gene" downshifts complement(1263896) /Source="Nicolas_upshifts" /id="D720" /incds=0 /nref=25 /ntot=112 /MaxReadThrough="0.698199999999999" /MaxDrop="4.30578" /score="-6.41557266" /energy="-13.5" /TU="NA" /idTUdmin="U1063" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1264364..1264383) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1264380) /Source="Nicolas_upshifts" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1264382..1264489) /Source="Nicolas_S_feature" /locus_tag="new_1383187_1383294_c" /HighExp="BMM, MG 10, MG 15, MG 5, MG t5, GM 25, B36, Gly, B60, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.044, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S469" promotor_-35 complement(1264399..1264402) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1264458 /Source="Nicolas_upshifts" /id="D721" /incds=0 /nref=9 /ntot=34 /MaxReadThrough="0.95942" /MaxDrop="5.95076" /score="15.2916843" /energy="-11.5" /TU="NA" /idTUdmin="U1062" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1264515..1266803) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /EC_number="2.1.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cobalamin-independent methionine synthase" /protein_id="NP_389201.2" /db_xref="EnsemblGenomes-Gn:BSU13180" /db_xref="EnsemblGenomes-Tr:CAB13175" /db_xref="GOA:P80877" /db_xref="InterPro:IPR002629" /db_xref="InterPro:IPR006276" /db_xref="InterPro:IPR013215" /db_xref="SubtiList:BG12616" /db_xref="UniProtKB/Swiss-Prot:P80877" /translation="MTTIKTSNLGFPRIGLNREWKKALEAYWKGSTDKDTFLKQIDEL FLSAVKTQIDQQIDVVPVSDFTQYDHVLDTAVSFNWIPKRFRHLTDATDTYFAIARGI KDAVSSEMTKWFNTNYHYIVPEYDESIEFRLTRNKQLEDYRRIKQEYGVETKPVIVGP YTFVTLAKGYEPSEAKAIQKRLVPLYVQLLKELEEEGVKWVQIDEPALVTASSEDVRG AKELFESITSELSSLNVLLQTYFDSVDAYEELISYPVQGIGLDFVHDKGRNLEQLKTH GFPTDKVLAAGVIDGRNIWKADLEERLDAVLDILSIAKVDELWIQPSSSLLHVPVAKH PDEHLEKDLLNGLSYAKEKLAELTALKEGLVSGKAAISEEIQQAKADIQALKQFATGA NSEQKKELEQLTDKDFKRPIPFEERLALQNESLGLPLLPTTTIGSFPQSAEVRSARQK WRKAEWSDEQYQNFINAETKRWIDIQEELELDVLVHGEFERTDMVEYFGEKLAGFAFT KYAWVQSYGSRCVRPPVIYGDVEFIEPMTVKDTVYAQSLTSKHVKGMLTGPVTILNWS FPRNDISRKEIAFQIGLALRKEVKALEDAGIQIIQVDEPALREGLPLKTRDWDEYLTW AAEAFRLTTSSVKNETQIHTHMCYSNFEDIVDTINDLDADVITIEHSRSHGGFLDYLK NHPYLKGLGLGVYDIHSPRVPSTEEMYNIIVDALAVCPTDRFWVNPDCGLKTRQQEET VAALKNMVEAAKQARAQQTQLV*" /label="metE CDS" gene complement(1264515..1266803) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /label="metE gene" downshifts complement(1264534) /Source="Nicolas_upshifts" /id="D722" /incds=0 /nref=212 /ntot=239 /MaxReadThrough="5.25958" /MaxDrop="7.50935" /score="29.3354648" /energy="-11.5" /TU="U1064,U1065" /idTUdmin="U1063" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature complement(1266804..1266866) /Source="Nicolas_S_feature" /locus_tag="new_1385609_1385671_c" /HighExp="MG 15, MG 5, MG t5, BMM, T-1.40H, MG 25, MG 10, GM 25, Mal, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.044, 1, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S470" promotor_no_box complement(1266826..1266926) /Source="Nicolas_upshift_promotors" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1266866) /Source="Nicolas_upshifts" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1266931..1267086) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762, 22543867" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762, 22543867; Product type n : RNA" /function="16.3: Control" /label="mswB RNA" gene complement(1266931..1267086) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /label="mswB gene" downshifts complement(1266932) /Source="Nicolas_upshifts" /id="D723" /incds=0 /nref=55 /ntot=106 /MaxReadThrough="8.12248" /MaxDrop="6.4813" /score="24.0596293" /energy="-16.2" /TU="U1065,U1066" /idTUdmin="U1066" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1267119..1267138) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1267131) /Source="Nicolas_upshifts" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1267133..1267218) /Source="Nicolas_S_feature" /locus_tag="new_1385938_1386023_c" /HighExp="BT, BC, B36, M9-stat, T5.0H, S3, S6, T4.0H, S5, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S471" promotor_-35 complement(1267154..1267161) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1267219..1268178) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3087947, 14680823, 23569278" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3087947, 14680823, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="intracellular serine protease" /protein_id="NP_389202.1" /db_xref="EnsemblGenomes-Gn:BSU13190" /db_xref="EnsemblGenomes-Tr:CAB13176" /db_xref="GOA:P11018" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG10674" /db_xref="UniProtKB/Swiss-Prot:P11018" /translation="MNGEIRLIPYVTNEQIMDVNELPEGIKVIKAPEMWAKGVKGKNI KVAVLDTGCDTSHPDLKNQIIGGKNFTDDDGGKEDAISDYNGHGTHVAGTIAANDSNG GIAGVAPEASLLIVKVLGGENGSGQYEWIINGINYAVEQKVDIISMSLGGPSDVPELK EAVKNAVKNGVLVVCAAGNEGDGDERTEELSYPAAYNEVIAVGSVSVARELSEFSNAN KEIDLVAPGENILSTLPNKKYGKLTGTSMAAPHVSGALALIKSYEEESFQRKLSESEV FAQLIRRTLPLDIAKTLAGNGFLYLTAPDELAEKAEQSHLLTL*" /label="ispA CDS" gene complement(1267219..1268178) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /label="ispA gene" S_feature complement(1268179..1268230) /Source="Nicolas_S_feature" /locus_tag="new_1386984_1387035_c" /HighExp="BT, B36, BC, T5.0H, M9-stat, T0.30H, T3.30H, T3.0H, T4.0H, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S472" promotor_-10 complement(1268223..1268242) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1268235) /Source="Nicolas_upshifts" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1268256..1268262) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1268347..1268350 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1268363 /Source="Nicolas_upshifts" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1268366..1268385 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1268401..1269234 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_389203.1" /db_xref="EnsemblGenomes-Gn:BSU13200" /db_xref="EnsemblGenomes-Tr:CAB13177" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12609" /db_xref="UniProtKB/Swiss-Prot:O34860" /translation="MKLNEKLYAFFSEHVEQMAEEWIETMEESDPNSLYALHNATVTE ELKEQDREFYRHLNYMYVLPEKQFLEEFQEWVIELTNDQKHLDTPVQYVIREFMRNRR LYTKYFEKFAEENESAFEPGEKQKWADLIVKVFDFTIYTFVDHAEMNAKQQLNAQREM ILELSSPVITLSKSTALLPLVGDIDTERAKFILENTLQACAKRRVEHLLIDLSGVVVV DTMVAHQIFKLIEALNLIGVRSTLSGIRPEIAQTAVQLGIDFSNITIKTNLAQALNYH Q*" /label="rsbRB CDS" gene 1268401..1269234 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /label="rsbRB gene" downshifts 1269210 /Source="Nicolas_upshifts" /id="D724" /incds=0 /nref=219 /ntot=254 /MaxReadThrough="3.01586" /MaxDrop="6.07238" /score="22.2655638" /energy="-12.1" /TU="NA" /idTUdmin="U1067" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1269265..1270029) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, transmembrane T component" /protein_id="NP_389204.1" /db_xref="EnsemblGenomes-Gn:BSU13210" /db_xref="EnsemblGenomes-Tr:CAB13178" /db_xref="GOA:O34572" /db_xref="InterPro:IPR003339" /db_xref="SubtiList:BG13248" /db_xref="UniProtKB/Swiss-Prot:O34572" /translation="MKQPLHLINPTVKAAAVFCCVVMLSFIYNPYTPACFYIIIVAGV LLAAGIPLKKWLLFTIPFLILAFGCVWTAAVFGKVPTTPDNFLFQAGPISINSDNVSV GISLGFRILCFSALSMMFVFTTDPILFMLSLVQQCRLSPKLAYGVIAGFRFLPLLKDE VQLIQQAHKIRGGAAESGIINKISALKRYTIPLLASAIRKAERTALAMESKGFTGSRN RTYYRTLSVNRRDWVFFCLVLLLFAGSFLVSLCFAS*" /label="thiX CDS" gene complement(1269265..1270029) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /label="thiX gene" downshifts complement(1269286) /Source="Nicolas_upshifts" /id="D725" /incds=0 /nref=143 /ntot=164 /MaxReadThrough="0.824010000000001" /MaxDrop="6.67697" /score="34.7739353" /energy="-12.1" /TU="NA" /idTUdmin="U1069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1270004..1271647) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine ABC transporter (ATP-binding subunit)" /protein_id="NP_389205.2" /db_xref="EnsemblGenomes-Gn:BSU13220" /db_xref="EnsemblGenomes-Tr:CAB13179" /db_xref="GOA:O34362" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13249" /db_xref="UniProtKB/Swiss-Prot:O34362" /translation="MQAFDELLTVEQLSFSYEEDEKPVFQDISFELQKGECVLLLGPS GCGKSSLALCLNGLYPEACDGIQSGHVFLFQKPVTDAETSETITQHAGVVFQDPDQQF CMLTVEDEIAFGLENLQIPKEEMTEKINAVLEKLRITHLKEKMISTLSGGQKQKVALA CILAMEPELIILDEPTSLLDPFSAREFVHLMKDLQREKGFSLLVIEHQLDEWAPWIER TIVLDKSGKKALDGLTKNLFQHEAETLKKLGIAIPKVCHLQEKLSMPFTLSKEMLFKE PIPAGHVKKKKAPSGESVLEVSSLSFARGQQAIFKDISFSLREGSLTALVGPNGTGKS TLLSVLASLMKPQSGKILLYDQPLQKYKEKELRKRMGFVFQNPEHQFVTDTVYDELLF GQKANAETEKKAQHLLQRFGLAHLADHHPFAISQGQKRRLSVATMLMHDVKVLLLDEP TFGQDARTAAECMEMIQRIKAEGTAVLMITHDMELVSSYADSVLVLHDTGLAFDGSPA QLFSQETGLVQKAKLTLPLLYEWMAFQEEVRDEATVTSH*" /label="thiW CDS" gene complement(1270004..1271647) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /label="thiW gene" CDS complement(1271634..1272233) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 27447050, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 27447050, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, permease component" /protein_id="NP_389206.2" /db_xref="EnsemblGenomes-Gn:BSU13230" /db_xref="EnsemblGenomes-Tr:CAB13180" /db_xref="GOA:O34738" /db_xref="InterPro:IPR017195" /db_xref="PDB:5EDL" /db_xref="SubtiList:BG13250" /db_xref="UniProtKB/Swiss-Prot:O34738" /translation="MKSWKVKEIVIMSVISIVFAVVYLLFTHFGNVLAGMFGPIAYEP IYGIWFIVSVIAAYMIRKPGAALVSEIIAALVECLLGNPSGPMVIVIGIVQGLGAEAV FLATRWKAYSLPVLMLAGMGSSVASFIYDLFVSGYAAYSPGYLLIMLVIRLISGALLA GLLGKAVSDSLAYTGVLNGMALGKELKKKRKRASEHASL*" /label="thiV CDS" gene complement(1271634..1272233) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /label="thiV gene" CDS complement(1272235..1272837) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15451668, 16291685, 16356850, 20471400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15451668, 16291685, 16356850, 20471400; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiamine-binding protein (oxidation stress protein)" /protein_id="NP_389207.1" /db_xref="EnsemblGenomes-Gn:BSU13240" /db_xref="EnsemblGenomes-Tr:CAB13181" /db_xref="GOA:O34911" /db_xref="InterPro:IPR011522" /db_xref="InterPro:IPR015835" /db_xref="InterPro:IPR029756" /db_xref="PDB:1S7H" /db_xref="PDB:1S99" /db_xref="PDB:1SBR" /db_xref="SubtiList:BG13251" /db_xref="UniProtKB/Swiss-Prot:O34911" /translation="MEHICGTSRIAGFRFSLYPMTDDFISVIKSALKKTDTSKVWTKT DHISTVLRGSIDHVFDAAKAIYLHAANSEQHIVMNGTFSIGCPGDTQGDTYLSKGDKR VNEDAVRGLKAEAPCQFALYPMNEPDYMGLIMEAVDIAKAQGTFVQGVHYASELDGDA HDVFSTLEAVFRMAEQQTNHITMTVNLSANSPSRKNRKQG*" /label="thiU CDS" gene complement(1272235..1272837) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /label="thiU gene" downshifts complement(1272915) /Source="Nicolas_upshifts" /id="D726" /incds=0 /nref=28 /ntot=88 /MaxReadThrough="7.47395" /MaxDrop="5.73297" /score="19.7469386" /energy="-10.9" /TU="U1069" /idTUdmin="U1069" /TUdmin="-3629" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1272934..1273046) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /product="thiamine pyrophosphate riboswitch" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswB RNA" gene complement(1272934..1273046) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /label="tswB gene" promotor_-35 1273047..1273050 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1273061..1273080) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1273066..1273085 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1273077 /Source="Nicolas_upshifts" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1273082) /Source="Nicolas_upshifts" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1273095..1273102) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1273148..1273834 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YkoH]" /protein_id="NP_389208.1" /db_xref="EnsemblGenomes-Gn:BSU13250" /db_xref="EnsemblGenomes-Tr:CAB13182" /db_xref="GOA:O34903" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13252" /db_xref="UniProtKB/Swiss-Prot:O34903" /translation="MEKGHILIVEDEEKIARVLQLELEYEGYSVTIKHNGTEGLDAAA EGGYSLVLLDVMLPGLSGLEVLRRLRKTDSQTPVILLTARDSIPDKVTGLDIGANDYV TKPFEIEELLARIRAALRQNGTKTEDIGTFLTYDDLRVNEKTREVRRGDKEVELTPRE FDLLVYMLKHPQQVLTREQILSSVWGFDYIGDTNVVDVYIRYIRKKLDYPYEKQLIHT IRGVGYAIKG*" /label="ykoG CDS" gene 1273148..1273834 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /label="ykoG gene" CDS 1273838..1275202 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YkoG]" /protein_id="NP_389209.1" /db_xref="EnsemblGenomes-Gn:BSU13260" /db_xref="EnsemblGenomes-Tr:CAB13183" /db_xref="GOA:O34638" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13253" /db_xref="UniProtKB/Swiss-Prot:O34638" /translation="MKLKTKIHLYTSISLLILLILVHTAVYLIFSSALTSKDAARLAD ETDNIAEALRAAETEGVALQDMLQAYLPANGMVRVVNGDQKAVMTITKEKAYKDFPLS FHSGETADVRKPDGKLFAEAAVPVIWTDGQVVSLQLVERLENTEESLFLLKIILIAAS AAVCIASFFAGSLLARRIINPIRRLMITMKDIQRDKEFKTISLEGQSNDELYQMGLTF NEMAMMLKEHYDKQQQFVQDASHELKTPLTIIESYSSLMKRWGAKKPEVLEESIEAIH SEAVHMKKLTNQLLALAKSHQGLEVDLKTIDLIKAARAVMQTLQSVYQRDILLETDKE SLLVKADEERIKQLLTILLDNAIKYSEKPIEMSAGTRNGRPFLSVRDEGIGIPEEHIP HLFERFYRADEARNRKTGGTGLGLSIAKQIADEHGIELSVKSKPGQGTAVTMQFSEQN GGGR*" /label="ykoH CDS" gene 1273838..1275202 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /label="ykoH gene" CDS 1275199..1275879 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295; Product type m : membranecomponent" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389210.1" /db_xref="EnsemblGenomes-Gn:BSU13270" /db_xref="EnsemblGenomes-Tr:CAB13184" /db_xref="GOA:O34551" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13254" /db_xref="UniProtKB/Swiss-Prot:O34551" /translation="MTKTIKTVSFAAAAILVVIICTFLIIRQTHENVLSKETVVKKVE ASYEGKVTKATQSKDKKTYDITLENPKGTYFVKADAISADILSMNRVKAVNPSAMTEK EAEHLALERVPGTVKKQTRQSQVATYTIQKEDGKTYEVKVDMQAKTVLSADQISSKDQ QKTPITKKEAKTIAERKTGGTADDADLEESEGTLIFEVDVDLPDNKEATVKINAYTGK VANIVYED*" /label="ykoI CDS" gene 1275199..1275879 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /label="ykoI gene" promotor_-35 1275908..1275913 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1275929..1275947 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1275932 /Source="Nicolas_upshifts" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1275971..1276483 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17209068; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389211.1" /db_xref="EnsemblGenomes-Gn:BSU13280" /db_xref="EnsemblGenomes-Tr:CAB13185" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13255" /db_xref="UniProtKB/Swiss-Prot:O35012" /translation="MLKKKWMVGLLAGCLAAGGFSYNAFATENNENRQASSKTDALTE QEAEAIAKTVVDGTVEDIDRDLYNGKEVYEVEIEKEGEDYDVYVDIHTKQALNDPLKE KAEQVAITKEEAEEIALKQTGGTVTESKLDEDDGAYIYEMEIQTKQGTETEFEISAKD GRIIKQEIDD*" /label="ykoJ CDS" gene 1275971..1276483 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /label="ykoJ gene" downshifts 1276469 /Source="Nicolas_upshifts" /id="D727" /incds=0 /nref=52 /ntot=228 /MaxReadThrough="3.74302" /MaxDrop="6.03059" /score="28.1760649" /energy="-13.7" /TU="U1070" /idTUdmin="U1070" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 1276514..1276520 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1276534..1276545 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1276535 /Source="Nicolas_upshifts" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1276566..1276703 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389212.1" /db_xref="EnsemblGenomes-Gn:BSU13290" /db_xref="EnsemblGenomes-Tr:CAB13186" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG13332" /db_xref="UniProtKB/Swiss-Prot:O34405" /translation="MEKKEEQYINQAEYVPHPTKEGEYALFLHETYHLLSEDDETQTT E*" /label="ykzD CDS" gene 1276566..1276703 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /label="ykzD gene" downshifts 1276676 /Source="Nicolas_upshifts" /id="D728" /incds=0 /nref=7 /ntot=31 /MaxReadThrough="1.81189" /MaxDrop="3.56977" /score="-4.52149284" /energy="-5.9" /TU="NA" /idTUdmin="U1070" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 1276762..1276769 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1276783..1276802 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1276785..1277104 /Source="Nicolas_S_feature" /locus_tag="new_1395590_1395909" /HighExp="LBGstat, LBGtran, M40t45, MG 25, Mt0, Salt, MG 45, LPhT, BMM, MG t5" /AntisenseName="ykzO" /AntisenseCor="-0.16301119751811899" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S473" upshifts 1276785 /Source="Nicolas_upshifts" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1276817..1276970 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /product="magnesium riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 17803910, 21315082, 28455443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 17803910, 21315082, 28455443; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="swmG RNA" gene 1276817..1276970 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /label="swmG gene" promotor_-35 1277082..1277091 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1277104..1277123 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1277106..1277207 /Source="Nicolas_S_feature" /locus_tag="new_1395911_1396012" /HighExp="LBGstat, LBGtran, M40t45, Mt0, LPhT, Paraq, MG t5, MG 25, MG 60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99773400000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.876, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S474" upshifts 1277106 /Source="Nicolas_upshifts" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" CDS 1277208..1278563 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 22970223, 24415722, 24968120, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 22970223, 24415722, 24968120, 25182490; Product type t : transporter" /codon_start=1 /transl_table=11 /product="magnesium transporter" /protein_id="NP_389213.1" /db_xref="EnsemblGenomes-Gn:BSU13300" /db_xref="EnsemblGenomes-Tr:CAB13187" /db_xref="GOA:O34442" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006667" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR006669" /db_xref="InterPro:IPR036739" /db_xref="SubtiList:BG13256" /db_xref="UniProtKB/Swiss-Prot:O34442" /translation="MVQNMTYDELILRIIILLRDGKIRDFRSVIDELQPYDMAFIFKE MPEKHRARYLSYLTVDDITDMIGELEREFQLVVLNKVGKTKATLAMNKMDNDDLAQLL EEMDEELKEQLLSSMEASESKAVQLLMNYPADSAGRMMTNRYVWIPQHYTVKDAVVKL KSFAEIAESINYLYVINESKQLVGVLSYRDLILGEPEEKVQDLMFTRVISADALQDQE EVARLIERYDFLAIPVVEENNVLVGIVTVDDIIDVVIREADEDYEKFAASGKDITFDT KAYVAAYRRLPWLILLLFIGLISGSIISYFEDALKQVVALAFFMPMVSGMTGNTGTQS LAVVIRGLSKEEMNKKTIVRLIFREFRTSIFIGAVCSVLIAIVSIIWQGNALLGFVVA SSLFLTLIIGTMSGTIIPIILHKLKVDPAIASGPLITTLNDILSLLIYFGIATAFIHS L*" /label="mgtE CDS" gene 1277208..1278563 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /label="mgtE gene" downshifts 1278554 /Source="Nicolas_upshifts" /id="D729" /incds=0 /nref=160 /ntot=239 /MaxReadThrough="1.02063" /MaxDrop="7.38933" /score="-4.14569718" /energy="-8.9" /TU="NA" /idTUdmin="U1072" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1278606..1278938) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen sensing transcriptional regulator" /protein_id="NP_389214.1" /db_xref="EnsemblGenomes-Gn:BSU13310" /db_xref="EnsemblGenomes-Tr:CAB13188" /db_xref="GOA:Q45666" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG11805" /db_xref="UniProtKB/Swiss-Prot:Q45666" /translation="MTTEDHSYKDKKVISIGIVSELTGLSVRQIRYYEERKLIYPQRS SRGTRKYSFADVERLMDIANKREDGVQTAEILKDMRKKEQMLKNDPQVRKKMLEGQLN AHFRYKNR*" /label="tnrA CDS" gene complement(1278606..1278938) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /label="tnrA gene" promotor_-10 complement(1278954..1278973) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1278964) /Source="Nicolas_upshifts" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1278966..1279354) /Source="Nicolas_S_feature" /locus_tag="new_1397771_1398159_c" /HighExp="M9-stat, BC, LoTm, T1.30H, T0.30H, T2.0H, S8, C30, T4.0H, T2.30H" /AntisenseName="ykzB" /AntisenseCor="-3.3870578787867499E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.92" /TUlongSig="NA" /TUlongPSig="NA" /label="S475" promotor_-35 complement(1278989..1278994) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1279026..1279126 /Source="Nicolas_upshift_promotors" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1279086 /Source="Nicolas_upshifts" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="upshifts" CDS 1279133..1279288 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389215.1" /db_xref="EnsemblGenomes-Gn:BSU13320" /db_xref="EnsemblGenomes-Tr:CAB13189" /db_xref="SubtiList:BG13330" /db_xref="UniProtKB/Swiss-Prot:O34923" /translation="MEEEKAVSLAKEIIELDIKRDEMLETFMQLAGEQAFQLLRSVQN GQYRKSS*" /label="ykzB CDS" gene 1279133..1279288 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /label="ykzB gene" promotor_-35 1279297..1279304 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1279311..1279328 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1279328 /Source="Nicolas_upshifts" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1279339..1279358) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1279354) /Source="Nicolas_upshifts" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1279372..1279378) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1279376..1279558 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389216.1" /db_xref="EnsemblGenomes-Gn:BSU13330" /db_xref="EnsemblGenomes-Tr:CAB13190" /db_xref="SubtiList:BG13257" /db_xref="UniProtKB/Swiss-Prot:O34763" /translation="MSNLLKSALEKERRHYSEKLYQIGVYNKEVMNKMTISELRKEYA YFFRSITNHKNYPYTR*" /label="ykoL CDS" gene 1279376..1279558 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /label="ykoL gene" downshifts 1279526 /Source="Nicolas_upshifts" /id="D730" /incds=0 /nref=2 /ntot=8 /MaxReadThrough="3.83398" /MaxDrop="4.6651" /score="19.6832496" /energy="-11.2" /TU="U1076" /idTUdmin="U1075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1279583..1279591 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1279602..1279620 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1279608..1279690 /Source="Nicolas_S_feature" /locus_tag="new_1398413_1398495" /HighExp="T3.0H, M9-stat, T1.30H, T2.30H, Lbstat, T3.30H, Lbtran, S2, T4.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, Sig-" /TUshortPSig="0.996, 0.00699" /TUlongSig="NA" /TUlongPSig="NA" /label="S476" upshifts 1279608 /Source="Nicolas_upshifts" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" CDS 1279691..1280155 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_389217.1" /db_xref="EnsemblGenomes-Gn:BSU13340" /db_xref="EnsemblGenomes-Tr:CAB13191" /db_xref="GOA:O34949" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13258" /db_xref="UniProtKB/Swiss-Prot:O34949" /translation="MMRLSFNEEEVERAMNLYRVFARAFKSVSEHSIRDSKEHGFNPT EFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRSVYAH LTDKGNEYLDKIYPIHALRIARAFSGLSPDEQDQLIVLLKKAGIHSQHLLFR*" /label="ykoM CDS" gene 1279691..1280155 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /label="ykoM gene" downshifts 1280140 /Source="Nicolas_upshifts" /id="D731" /incds=0 /nref=70 /ntot=210 /MaxReadThrough="2.86787" /MaxDrop="5.38705" /score="24.8730632" /energy="-9.8" /TU="U1078" /idTUdmin="U1078" /TUdmin="-112" /isTUend="FALSE" /label="downshifts" CDS complement(1280170..1281291) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389218.2" /db_xref="EnsemblGenomes-Gn:BSU13350" /db_xref="EnsemblGenomes-Tr:CAB13192" /db_xref="GOA:C0SPB9" /db_xref="InterPro:IPR009695" /db_xref="SubtiList:BG13259" /db_xref="UniProtKB/Swiss-Prot:C0SPB9" /translation="MKNILIFPFLSISTGHHHVADALQAELESQGLAAEKIDIFSHSY RRLEKLSSVAYLKWIQYFPKTYSGIYRLLACGEFQHDKRYFMYEWLFTQQMRHILQEK QPDIAFCTHALPSYLLNRLKPEYPNLTVVNVYTDFFVNQLWGRKNIDYHFVPSTEVKK QLISEGIDQNNIYLTGIPVHQNFEMESADTLQHHPPYTIIITGGSMGVGGILKWVQEL SPGGKILYKILCGRNEKLYSYVKSLHHPLIEAIPYLHSKAEMNRLYEQATGIMTKPGG VTISECLQKRLPVFIYHALPGQEEMNLNLLHERKLVTDMRNWDMQKAEEYIAAFFQSN EQMKEYKKHVNGYLGEMSDRKIKDVLKRIIWKQKNTLLK*" /label="ykoN CDS" gene complement(1280170..1281291) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /label="ykoN gene" promotor_-35 1280579..1280587 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1280601..1280620 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1280604..1281382 /Source="Nicolas_S_feature" /locus_tag="new_1399409_1400187" /HighExp="S6, S8, S7, S5, BT, B36, S4, S3, Pyr, G/S" /AntisenseName="ykoN" /AntisenseCor="0.84084970563549499" /AntisenseRegPval="-72.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S477" upshifts 1280604 /Source="Nicolas_upshifts" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1281320..1281331) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1281340) /Source="Nicolas_upshifts" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1281346..1281352) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1281383..1281934 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389219.2" /db_xref="EnsemblGenomes-Gn:BSU13360" /db_xref="EnsemblGenomes-Tr:CAB13193" /db_xref="SubtiList:BG13260" /db_xref="UniProtKB/Swiss-Prot:O34495" /translation="MKTCFLSIWRVVDPIYFFFSRLSLIDNDQKSVFRVRLTKYKGHH VVLSDGTHIRKNDVLVKIHLHNIKLIRELQSIESAVRKGIIIYQKVYQSMPLLLDYIN NHKKSEKIKGIIGITMLDKGVERLGFDVITPVNPFYRCFKKVSHVPILYLTSKPVSLR HLPNSSYLFISKEKLQKTYQKKD*" /label="ykoP CDS" gene 1281383..1281934 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /label="ykoP gene" downshifts 1281902 /Source="Nicolas_upshifts" /id="D732" /incds=0 /nref=4 /ntot=25 /MaxReadThrough="3.31887" /MaxDrop="3.7149" /score="-2.92393792" /energy="-7" /TU="U1079" /idTUdmin="U1079" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(1281962..1282774) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metallophosphoesterase" /protein_id="NP_389220.1" /db_xref="EnsemblGenomes-Gn:BSU13370" /db_xref="EnsemblGenomes-Tr:CAB13194" /db_xref="GOA:O35040" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13261" /db_xref="UniProtKB/Swiss-Prot:O35040" /translation="MFTILLSLAILVFVPFLYKANRNTKDVKVNTISIDQKDGLPARK KLNILHLSDLHLENISVSPEELYHLTKDQPVDIIALTGDFLDRKRNIPKLAGYLNALQ KLKPAYGMYAVFGNHDYVLKEEDFQRLKRVLEENGCITLQNEHVRIETAAGPVNIIGI DDYSTNRSNITGSYQSLENGYHLVLTHDPNIILDMKDVHYDYLLSGHFHGGQIHWPKP YHLVKMGKLVRMNMIKGLHYHHDKPFYISEGLGQTGVNIRVGSRPEVTFHQI*" /label="ykoQ CDS" gene complement(1281962..1282774) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /label="ykoQ gene" promotor_-10 complement(1282734..1282753) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1282748) /Source="Nicolas_upshifts" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1282767..1282772) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1282875..1282881 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1282892..1282966 /Source="Nicolas_S_feature" /locus_tag="new_1401697_1401771" /HighExp="S5, S6, S7, S4, S8, T5.0H, ferm, nit, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S478" upshifts 1282892 /Source="Nicolas_upshifts" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1282895..1282906 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1282967..1284661 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389221.1" /db_xref="EnsemblGenomes-Gn:BSU13380" /db_xref="EnsemblGenomes-Tr:CAB13195" /db_xref="GOA:O34830" /db_xref="SubtiList:BG13262" /db_xref="UniProtKB/Swiss-Prot:O34830" /translation="MLRLMRQQKKETYYLWIALFLLLLYVSPLFILKEDAHIRVHDNL DSNIAWYKVLADSGEIVGKVDAAIPQIINGLPRDAFGTEWSGIVWLHAFFSSMTAYAI SQTVTRVVAFFGMYVLLKKHIIPEPKAAFIRIGVSLAFALTPFWPSGMLSTLGYPLAL WAFLNIRKGDISWREWLTLGLLPLYSSFVLGFFFFLAGMACFWLYDAITKRRWNLMFL GSIAFMTSIYLFVEYRLVYSMLFEHAPMHRIEFISSRHDVWHSLRLSIKNFVYGHNHV MTVHTVVILPILMVVFAALLFKRNRTKPENVYLFLCVLNYGLSLWYAFWFNKIWAVPK QKFAFLAEFNFARFHFLRPLVIYVSFALALYLIWRMGKGWKWLVYAAVAAQLMVLAPF NEEYTYGVHYNAPTFREFYASEQFKEIKEYIGRPQDSYRVASIGLHPSIAQYNGFYTL DTYNNLYPLSYKYEFRKIIEKELEKNSRLKQYFDEWGSRCYLFVDELGKRYDFKKNSK KTINNLQLNTDVFKKMGGRYIFSSVPIMNAEQNHLALVKTFDHKDSAWRIYLYETR*" /label="ykoS CDS" gene 1282967..1284661 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /label="ykoS gene" CDS 1284674..1285687 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /EC_number="2.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389222.1" /db_xref="EnsemblGenomes-Gn:BSU13390" /db_xref="EnsemblGenomes-Tr:CAB13196" /db_xref="GOA:O34755" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13263" /db_xref="UniProtKB/Swiss-Prot:O34755" /translation="MKQSQPVLTIVVPCFNEEEVFQETSHQLTEVVDDLIEEKLIAED SKILFVDDGSKDRTWALIAMESIRNKKVTGLKLACNVGHQKALLAGLHKAKNRSDCVI SIDADLQDDISVIRDFMLKYHEGCEIVYGVRRSRKTDTFFKRTTALGFYRLMNKLGIK LIYNHADFRLMNKRSLEELERYPEANLFLRGIVPMIGFKSAEVLYDRKERFAGKTKYP LKKMLSFAFNGITSFSVAPIRFFTLLGFVLFFLSAVAGIGAFIQKLLGHTNAGWASLI ISIWFLGGLQLMGIGIIGEYIGTIFSEVKRRPKYAIDIDLYNEQLSPLQRQEKERLEK KYS*" /label="ykoT CDS" gene 1284674..1285687 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /label="ykoT gene" downshifts 1285672 /Source="Nicolas_upshifts" /id="D733" /incds=0 /nref=13 /ntot=35 /MaxReadThrough="0.53349" /MaxDrop="4.80671" /score="19.4012674" /energy="-13.7" /TU="NA" /idTUdmin="U1082" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(1285713..1287548) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /EC_number="6.5.1.1" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12215643, 16497325, 17293412, 23691176, 25355514, 26826709" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12215643, 16497325, 17293412, 23691176, 25355514, 26826709; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit; 5'-2-deoxyribose-5-phosphate (dRP) lyase" /protein_id="NP_389223.1" /db_xref="EnsemblGenomes-Gn:BSU13400" /db_xref="EnsemblGenomes-Tr:CAB13197" /db_xref="GOA:O34398" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR014143" /db_xref="InterPro:IPR014145" /db_xref="InterPro:IPR014146" /db_xref="InterPro:IPR033652" /db_xref="SubtiList:BG13264" /db_xref="UniProtKB/Swiss-Prot:O34398" /translation="MAFTMQPVLTSSPPIGAEWRYEVKYDGYRCILRIHSSGVTLTSR NGVELSSTFPEITQFAKTAFQHLEKELPLTLDGEIVCLVNPCRADFEHLQVRGRLKRP DKIQESANARPCCFLAFDLLERSGEDVTLLSYLDRKKSLRELISAAKLPASPDPYAKE TIQSIPCYDHFDQLWEMVIKYDGEGIVAKKTNSKWLEKKRSSDWLKYKNFKQAYVCIT GFNPNNGFLTVSVLKNGIMTPIASVSHGMRDEEKSAIREIMEQHGHQTPSGEFTLEPS ICAAVQYLTILQGTLREVSFIGFEFQMDWTECTYAQVIRHSKPVHPKLQFTSLDKIIF EKNKKTKEDFIQYMIEVSDYLLPFLKNRAVTVIRYPHGSRSESFFQKNKPDYAPDFVQ SFYDGSHEHIVCEDMSTLLWLCNQLALEFHVPFQTIKSRRPAEIVIDLDPPSRDDFLM AVQAANELKRLLDSFGITSYPKLSGNKGIQLYIPLSPEAFTYEETRQFTQLIAEYCTN AFPELFTTERLIKNRHCKLYLDYLQHAEGKTIICPYSTRGNELGTVAAPLYWHEVQSS LTPALFTIDTVIDRIKKQGCPFFDFYRNPQDEPLSAILHQLKKKS*" /label="ligD CDS" gene complement(1285713..1287548) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /label="ligD gene" downshifts complement(1285762) /Source="Nicolas_upshifts" /id="D734" /incds=0 /nref=10 /ntot=54 /MaxReadThrough="0.67916" /MaxDrop="5.08051" /score="-8.48510187" /energy="-13.7" /TU="NA" /idTUdmin="U1083" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1287552..1288487) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11095673, 12215643, 16497325, 16780573, 23691176, 25355514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11095673, 12215643, 16497325, 16780573, 23691176, 25355514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit Ku; AP/deoxyribose 5'-phosphate (5'-dRP)-lyase" /protein_id="NP_389224.1" /db_xref="EnsemblGenomes-Gn:BSU13410" /db_xref="EnsemblGenomes-Tr:CAB13198" /db_xref="GOA:O34859" /db_xref="InterPro:IPR006164" /db_xref="InterPro:IPR009187" /db_xref="InterPro:IPR016194" /db_xref="SubtiList:BG13265" /db_xref="UniProtKB/Swiss-Prot:O34859" /translation="MNRTPSLHTKEKKGFIDMHTMWKGSISFGLVNIPIKLYAATEDK DIKLRSLHKEDHAPIKYEKVCTNCEKTLSPDEIVKGYEYVKGKYVVLTDEDLKSLKQE HEEKAVEIVDFVQLQEIDPIYFNRSYFVGPGDNGTKAYTLLREALRSTGKIGIANMTI RSKQQLAILRVYENCIVMESIHYPDEVRSAAQVPGVPDQSNVNDKELQTAITLIDELT AKFEPEKYEDTYRQALLQRVNDKLENKETAVTPDKAPPREDVIDLVSALQASIDRTRR PNRETPAAAPAQAAEPKGAGDKKQKTTRKKASGTS*" /label="ligV CDS" gene complement(1287552..1288487) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /label="ligV gene" promotor_-10 complement(1288458..1288469) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1288468) /Source="Nicolas_upshifts" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1288484..1288490) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1288524..1290926) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11728710, 17010156, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11728710, 17010156, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="YP_054577.2" /db_xref="EnsemblGenomes-Gn:BSU13420" /db_xref="EnsemblGenomes-Tr:CAB13199" /db_xref="GOA:O34311" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR005330" /db_xref="InterPro:IPR029787" /db_xref="InterPro:IPR035919" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG13266" /db_xref="UniProtKB/Swiss-Prot:O34311" /translation="MEIHVTYNTTLICLSILIACTASYISLELSRKVTINTGLKSKIW LIGGSLIMGFGIWSMHFVGMMAVHMEMPMEYEFMPLMAAIGASVSGSFVSLYFVSRHI LTYYRLLTGSVVLGASIASMHYIGMSAISRVMIIYEPILFTVSIIIAIAASFVSLKIF FDLAVKKHSEHLIFYKGVSSIVMGIGISGMHYTGMLAATFHKDMAPPGSHMEVQTFHW SIFVTLIIFCIQTLLLFSSHADRKFIKQSERIKDNEQRFQSLIVHNIDAIFILSLEGD IISSNHAGEEMISKFGFSMHDWRNYTSLKVKRLFEQVKKDKQAMNSDSDLITEKGQFH LNITLIPVEVNQELDSIYVICKDMTKQYKAEKEIHRMAHYDSLTDLPNRRHAISHLTK VLNREHSLHYNTVVFFLDLNRFKVINDALGHNVGDQLLQFAAKRLSSVVPDNGFIARL GGDEFIIILTDANTGTGEADVLARKIIQKFKKPFKIQDHTLVTSVSIGIAISPKDGTD GLELMKKADMAMYAAKERNKSKYRYYSFSIGNKETVKLNQEMVLREAIENDRFVLHYQ PQFSVKKQKMTGAEALIRLVTPDGQLRPPGEFIGVAEETGLIIDIGKWIIDEACKQAR IWHDKGYDLSVAINISARQFQSKDLIPLIKDTLNKYQLPPQLLEVEVTESMTMDNLNH SKKVLSSLTELGIRISIDDFGTGHSSLSYLKDFPIHRLKIDKSFIDDIQTHPKSEQIT GAIIAMGHQLSLQVIAEGVENAAQKQLLFEKGCDHLQGFFFSRPIPPEQFEQFIIEQP SQ*" /label="dgcW CDS" gene complement(1288524..1290926) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /label="dgcW gene" downshifts complement(1288556) /Source="Nicolas_upshifts" /id="D735" /incds=0 /nref=13 /ntot=101 /MaxReadThrough="1.93589" /MaxDrop="3.26543" /score="6.55794882" /energy="-9" /TU="NA" /idTUdmin="U1084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1290774..1290976) /Source="Nicolas_S_feature" /locus_tag="new_1409579_1409781_c" /HighExp="Cold, GM 25, GM 10, GM 45, GM 15, GM-0.2, GM-0.1, GM 5, GM 90, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S479" promotor_-10 complement(1290965..1290983) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1290976) /Source="Nicolas_upshifts" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1290997..1291004) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1291043..1291050 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1291064..1291083 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1291076 /Source="Nicolas_upshifts" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="upshifts" CDS 1291107..1291772 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23687963; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389226.1" /db_xref="EnsemblGenomes-Gn:BSU13430" /db_xref="EnsemblGenomes-Tr:CAB13200" /db_xref="GOA:O34908" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13267" /db_xref="UniProtKB/Swiss-Prot:O34908" /translation="MIHKHETRELVAIEELVMSWIEAFKSLSYFGIFLALSIEFIPAE VVLPLAGYWVSKGDMTLAGVVLAGSLGGVAGPLTLYWIGRYGGRPFLERFGKYLFIKP EALDKSDNFFKKHGGFVAFSGRFLPGIRTLISIPCGIAKMNVWVFSLYTFIAMLPITF VYVYLGVKLGENWKAVGSILDQYMLPIGIAILALFLLYLLMKKRKKRTHSEQLSVFLK NKR*" /label="ykoX CDS" gene 1291107..1291772 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /label="ykoX gene" promotor_-10 complement(1291641..1291660) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1291658) /Source="Nicolas_upshifts" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1291674..1291683) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1291767..1291774 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1291789..1291808 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1291802 /Source="Nicolas_upshifts" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1291828..1291961 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /product="manganese ion riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="mnrW RNA" gene 1291828..1291961 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /label="mnrW gene" CDS 1291849..1292823 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 15849754, 16850406, 25794618, 25794619; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative manganese-related ion transporter" /protein_id="NP_389227.1" /db_xref="EnsemblGenomes-Gn:BSU13440" /db_xref="EnsemblGenomes-Tr:CAB13201" /db_xref="GOA:O34997" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13268" /db_xref="UniProtKB/Swiss-Prot:O34997" /translation="MYSGNKVVISWIVSIGFVGMPEFMSSKTFALCRQRSFLHGPAGI RSDEEKENNFFGRVSFMDAALLLEYGWVLLVLIGLEGILAADNALVMAVMVKHLPEEK RKKALFYGLAGAFVLRFGSLFAISFLVNVWQVQAIGAIYLLYISASHLLKRYVFKKED THKETKQSGFWPTVLKVELADIAFAVDSILAAVALAVTLPGTSLPKIGGLDGGQFLVI LAGGIIGLVIMRFAASMFVKLLKERPSLETAAFVIVGWVGVKLALYTLAHRDIAVVSE HFIHSGTWKLIFWGVLAAIAVCGWFMSGGKKQPEGAQNEQKNSTRERA*" /label="ykoY CDS" gene 1291849..1292823 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /label="ykoY gene" downshifts 1291912 /Source="Nicolas_upshifts" /id="D736" /incds=1 /nref=38 /ntot=211 /MaxReadThrough="5.00041" /MaxDrop="4.46498" /score="15.8563987" /energy="-15" /TU="U1085,U1087" /idTUdmin="U1085" /TUdmin="-902" /isTUend="FALSE" /label="downshifts" downshifts 1292811 /Source="Nicolas_upshifts" /id="D737" /incds=0 /nref=16 /ntot=175 /MaxReadThrough="2.59801" /MaxDrop="4.20782" /score="24.4740487" /energy="-13.7" /TU="NA" /idTUdmin="U1085" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1292933..1292941 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1292955..1292963 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1292965 /Source="Nicolas_upshifts" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="upshifts" S_feature 1292968..1293054 /Source="Nicolas_S_feature" /locus_tag="new_1411773_1411859" /HighExp="M9-stat, T1.30H, T1.0H, T0.30H, T2.0H, T2.30H, HiTm, M0t90, T3.0H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29969800000000002" /TUshortSig="SigI" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S480" promotor_-35 1293027..1293034 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1293048..1293067 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1293056 /Source="Nicolas_upshifts" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="upshifts" CDS 1293087..1293842 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma factor (heat stress responsive)" /protein_id="NP_389228.1" /db_xref="EnsemblGenomes-Gn:BSU13450" /db_xref="EnsemblGenomes-Tr:CAB13218" /db_xref="GOA:O31654" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014244" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG13269" /db_xref="UniProtKB/Swiss-Prot:O31654" /translation="MKPVLSLLFKLGKKKQTLEKAVESIQKGNKDLQNELIQQYKPFI AKTVSSVCKRYIDEKDDEFSIGLIAFNEAIEKYSPEKGNSLLAFAELIIKRKVIDYIR KEARSAQNINIDLQEGDDQESSQSLIEAELSIDEYRRQIEQEQRREEILYFQKQLKDY GLSFKELLENSPKHTDARQNAIKVAMTLVEHEELAAILYTKKQLPVKQLEQLVSVSRK TIERNRKYIIAMCIIITGDYIYLKDYLKGVLHS*" /label="sigI CDS" gene 1293087..1293842 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /label="sigI gene" CDS 1293839..1294984 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17185538, 23199363, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17185538, 23199363, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="sigmaI modulating factor" /protein_id="NP_389229.1" /db_xref="EnsemblGenomes-Gn:BSU13460" /db_xref="EnsemblGenomes-Tr:CAB13219" /db_xref="GOA:O31655" /db_xref="InterPro:IPR024449" /db_xref="SubtiList:BG13272" /db_xref="UniProtKB/Swiss-Prot:O31655" /translation="MRRGIIVEKNKKFVTLLTPDGQFLKAKNDRHSYEIGEEIMLPSE TRMGRRASFFDFFKLRPFKMGIFTMTAIMLFIFIVLPVFSNNKAYAYMTIDINPSVEM ALNSDYEVIELTPLNDEGQKVVNDIDDWEKTDFKKVIDDIITDCSEHGYVKKSKEILI STVYENTEDNTYKKAVKKQLNDVTEKYKTTYRMESLESDMQTREKAKKEGVSTGSYIK SNEKNDNKDIKDDSSKPSGEEDQKSDENEDENTDQTDTQDSKQGDNEQLNDADSGDQK EEKADDQIDDSDKDKKIKESDENTNTEKDGDHEQTPIQDPQDKGNENNGADKGQSQYH RDWNNGEQGKNRSSSRRDNASDRRNPNGYSSDNHSAKNEDSPSAPGE*" /label="rsgI CDS" gene 1293839..1294984 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /label="rsgI gene" S_feature 1294985..1296144 /Source="Nicolas_S_feature" /locus_tag="new_1413790_1414949" /HighExp="HiTm, G135, G180, C30, G150, Cold, S8, MG 25, H2O2, Lbstat" /AntisenseName="ykrK" /AntisenseCor="0.122248209149143" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigI" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S481" CDS complement(1294995..1295189) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:3009397, 3112127, 3121585, 9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009397, 3112127, 3121585, 9852018; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_389230.1" /db_xref="EnsemblGenomes-Gn:BSU13470" /db_xref="EnsemblGenomes-Tr:CAB13220" /db_xref="GOA:P04833" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10788" /db_xref="UniProtKB/Swiss-Prot:P04833" /translation="MASRNKLVVPGVEQALDQFKLEVAQEFGVNLGSDTVARANGSVG GEMTKRLVQQAQSQLNGTTK*" /label="sspD CDS" gene complement(1294995..1295189) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /label="sspD gene" downshifts complement(1295002) /Source="Nicolas_upshifts" /id="D738" /incds=0 /nref=24 /ntot=36 /MaxReadThrough="1.67859" /MaxDrop="4.68215" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1090" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1295232..1295243) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1295242) /Source="Nicolas_upshifts" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1295258..1295264) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1295320..1296021) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22447908, 23042994" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22447908, 23042994; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of quality control" /protein_id="NP_389231.1" /db_xref="EnsemblGenomes-Gn:BSU13480" /db_xref="EnsemblGenomes-Tr:CAB13221" /db_xref="InterPro:IPR014975" /db_xref="SubtiList:BG13273" /db_xref="UniProtKB/Swiss-Prot:O31656" /translation="MNIFKLSRTDMVRLLYSLKGQGEHSPLDILVQSANMSAEKAANH LEIPEFLTRYERKKQKKEYGLSTNEIVELGNLCELTSLKSTAIQNWVKRDIKDLIGHP ELGKKYSIEQAVILLIVRDLKSIYDFEHIRAILKVAFNTISDRSDDVISPIAYYESCA YVLDAIHHQDTPSMKESNLQEIAEQETERLRHRFEELNDSQWLKIRQIIAITVLSILT FHIQATAHKMTADIL*" /label="htpK CDS" gene complement(1295320..1296021) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /label="htpK gene" downshifts complement(1295354) /Source="Nicolas_upshifts" /id="D739" /incds=0 /nref=174 /ntot=231 /MaxReadThrough="2.96889" /MaxDrop="5.30355" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1296022..1296102) /Source="Nicolas_S_feature" /locus_tag="new_1414827_1414907_c" /HighExp="LBGtran, dia0, LBGexp, Lbexp, Oxctl, G180, M0t45, C90, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S482" promotor_-10 complement(1296094..1296113) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1296102) /Source="Nicolas_upshifts" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1296118..1296125 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1296127..1296134) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1296139..1296158 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1296146 /Source="Nicolas_upshifts" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="upshifts" CDS 1296192..1297088 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11860552, 12081643, 16076848, 16573693, 22447908, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane protease" /protein_id="NP_389232.1" /db_xref="EnsemblGenomes-Gn:BSU13490" /db_xref="EnsemblGenomes-Tr:CAB13222" /db_xref="GOA:O31657" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR022919" /db_xref="SubtiList:BG13274" /db_xref="UniProtKB/Swiss-Prot:O31657" /translation="MAKRIFLFILTNILVLTTIGIVLSVLSSVTGVGTYFTADGGIDP MALLVFSLVVGFVGSFTSLAISRWMAKTMMGVRVLNPKKHSLSYEEQQLVDRVHRLSR SAGLTKMPEVGIYRSPEVNAFATGPSKRRSLVAVSSGLLEQMDDAAVEGVLAHEVAHI TNGDMVTMTLLQGIVNTFVVFLSRIAAWIASRFVKEDLAPIVHFIAMIIFQIVFSILG SLVVFAYSRHREFHADRGGADLAGKDKMIHALRTLKSYSSRILEDDQTAVQTLKINGK KRSSLFSTHPDLDERIRRLEAK*" /label="htpX CDS" gene 1296192..1297088 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /label="htpX gene" downshifts 1297082 /Source="Nicolas_upshifts" /id="D740" /incds=0 /nref=203 /ntot=268 /MaxReadThrough="3.02778" /MaxDrop="6.27746" /score="38.5173589" /energy="-13.4" /TU="NA" /idTUdmin="U1092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1297193..1297197 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1297213..1297232 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1297217 /Source="Nicolas_upshifts" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="upshifts" CDS 1297262..1298611 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /EC_number="3.6.3.12" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 23963175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 23963175; Product type t : transporter" /codon_start=1 /transl_table=11 /product="K+-transporting ATPase" /protein_id="NP_389233.1" /db_xref="EnsemblGenomes-Gn:BSU13500" /db_xref="EnsemblGenomes-Tr:CAB13223" /db_xref="GOA:O31658" /db_xref="InterPro:IPR003445" /db_xref="SubtiList:BG13275" /db_xref="UniProtKB/Swiss-Prot:O31658" /translation="MRLKFGKLIQALSPAQLIALYYFLAVTVAVILLSLPAAHKPGAD WTFIDALFTAVSSVSVTGLTVVDTADTFSTIGIFILAFVLQFGGIGIMTLGTFIWLIM GKRIGLKERKLIMVDQNQSQFSGIVNLMKQVLFLILWIEFFGGLILGTYFLTYYDSYQ EAYLHGFFASISATTNGGFDITGNSMIPFRHDYFVQFITMLLIIFGAIGFPVLVEVKD FLFSKHRRYPFTLFTKITTITFGSLVLFGAIGIFALEANHAFAGKSWHDILFLSLFQS TATRSGGLATIDISQLSDSTLFFICALMFIGASPSSVGGGIRTTTFALNLLALFHFAR GNKAVKVFKRELHPADLMKSLVVTMMAILLVFGATLILTITEKHSLLELLFEVCSAFG TTGLSLGITADLSSVGKCVIMIVMFIGRIGILTFLYLIGRKEIEANYHYPKERVIIG* " /label="ktrD CDS" gene 1297262..1298611 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /label="ktrD gene" downshifts 1298599 /Source="Nicolas_upshifts" /id="D741" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="0.838800000000001" /MaxDrop="4.37717" /score="20.0478288" /energy="-10.7" /TU="NA" /idTUdmin="U1093" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1298660..1298666 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1298680..1298691 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1298688..1298755 /Source="Nicolas_S_feature" /locus_tag="new_1417493_1417560" /HighExp="S8, S6, S7, S5, ferm, nit, BT, B36, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S483" upshifts 1298688 /Source="Nicolas_upshifts" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1298756..1298911 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097718.1" /db_xref="EnsemblGenomes-Gn:BSU13509" /db_xref="EnsemblGenomes-Tr:CAX52609" /db_xref="UniProtKB/Swiss-Prot:C0H402" /translation="MKRKAEVNEAIKNNNTPTESMDPNSYKTQYHDDPNFRGANRNSK QGQQGGM*" /label="ykzP CDS" gene 1298756..1298911 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /label="ykzP gene" CDS 1298914..1299090 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389234.1" /db_xref="EnsemblGenomes-Gn:BSU13510" /db_xref="EnsemblGenomes-Tr:CAB13224" /db_xref="SubtiList:BG13333" /db_xref="UniProtKB/Swiss-Prot:O31659" /translation="MKKNRHSRDMQNHKKPMNKKVLEEEFSSELGDYNAGKIIETLEV TKPEKKKEKNKKQQ*" /label="ykzE CDS" gene 1298914..1299090 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /label="ykzE gene" promotor_no_box 1298980..1299080 /Source="Nicolas_upshift_promotors" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1299040 /Source="Nicolas_upshifts" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1299086 /Source="Nicolas_upshifts" /id="D742" /incds=0 /nref=56 /ntot=112 /MaxReadThrough="2.40289" /MaxDrop="8.38761" /score="26.5107018" /energy="-19.7" /TU="NA" /idTUdmin="U1094" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1299133..1300155) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /EC_number="2.3.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral membrane protein; putative acyltransferase" /protein_id="NP_389235.1" /db_xref="EnsemblGenomes-Gn:BSU13520" /db_xref="EnsemblGenomes-Tr:CAB13225" /db_xref="GOA:O31660" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG13276" /db_xref="UniProtKB/Swiss-Prot:O31660" /translation="MSKSRDSYFDNAKFLLIFLVVFGHILRSFINDNHFMLYLYKFIY TFHMPAFILVSGYFAKGFKRAGYVKKLAVKLIIPYLIFQIIYSVFYYIMQDESMANVN PIDPQWSLWFLVSLFFWNLLLYPFSKLSKQWALFVSCGIAVLIGYLDFVSSTLSLSRT FVFLPMFLVGFYLNKHHFDLLRSKRGKQIALGVLAAVFVICWGIDFDYSFLFGSKPYS SFGDVTLVSGLSRIGWYVLAFGATFSFLALVPQKRYFFTKWGTRTFYVYLLHGFIIKT LRQVGLEDWLTDYQSLVILLLLTAALTSVLSSNFVKTVAQPFIELRMTSLLQFVRGTG KNAYLK*" /label="ykrP CDS" gene complement(1299133..1300155) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /label="ykrP gene" downshifts complement(1299156) /Source="Nicolas_upshifts" /id="D743" /incds=0 /nref=11 /ntot=58 /MaxReadThrough="2.29259" /MaxDrop="3.64731" /score="30.4184602" /energy="-16.9" /TU="NA" /idTUdmin="U1096" /TUdmin=92 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1300200..1300219) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1300216) /Source="Nicolas_upshifts" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1300231..1300237) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1300344..1300352 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1300360 /Source="Nicolas_upshifts" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1300363..1300381 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1300408..1302624 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11069677, 12169614, 16166384, 25701730" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 12169614, 16166384, 25701730; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_389236.1" /db_xref="EnsemblGenomes-Gn:BSU13530" /db_xref="EnsemblGenomes-Tr:CAB13226" /db_xref="GOA:O31661" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13277" /db_xref="UniProtKB/Swiss-Prot:O31661" /translation="METLGVQTNSELREELNRLKEENARLKKELNQHQVIVNNTLDAI FICDNEMRIVQANEATERMLQVDSEDLKKRSVLDFLFSIPKDELNLSVKKFFKKGFLW KEVPIRLDCGATKYIEFLAKRGIGEDFFFVVMRDISSKKILEREFSMNEQLFKDLFDR AVDGIVLFDKDGGFIDANLSFCKSFEINHNELSHLSLYEFIDSGSRKDFDNIWKALNR KGKAKGELPVKLRSGVQKLFEFTITSNIISGFYMSIMRDITEKRSMELQLFKSEERFR EIFENAMDAIIIWSNDGRIVKANQSACKIFELPMNLLLKRKLCDFLVDSQQKYSITKR KYAKYGEIREELLFQMGNGQFKELEFTSKRTILENQHLTILRNVSDRKRMEKELRESE LKFRKVFNGSMDGNVLFDNQYRIIDANPLASHILGLSHEEIKQHSLLDIISAYEIENL ASPARQINFDEMDNEIPFLLSSGDNRKLEFSFKRNIIQNMNLAIFKDVTERKELEERL RKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLKGSVEGDYALYFNVITSELKRIES IITEFLILAKPQAIMYEEKHVTQIMRDTIDLLNAQANLSNVQMQLDLIDDIPPIYCEP NQLKQVFINILKNAIEVMPDGGNIFVTIKALDQDHVLISLKDEGIGMTEDKLKRLGEP FYTTKERGTGLGLMVSYKIIEEHQGEIMVESEEGKGTVFHITLPVRQNAEERRNDE*" /label="kinE CDS" gene 1300408..1302624 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /label="kinE gene" S_feature complement(1302399..1303339) /Source="Nicolas_S_feature" /locus_tag="new_1421204_1422144_c" /HighExp="Pyr, Glucon, C30, Glu, Mal, M/G, G/S, Heat, Fru, B36" /AntisenseName="ogt" /AntisenseCor="-0.33210294457391598" /AntisenseRegPval="-7.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S484" promotor_-35 1302477..1302484 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1302499..1302518 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1302501 /Source="Nicolas_upshifts" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="upshifts" CDS 1302621..1303118 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /EC_number="2.1.1.63" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2105461, 2308822, 2359121, 2506524, 7565865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105461, 2308822, 2359121, 2506524, 7565865; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O6-alkylguanine DNA alkyltransferase" /protein_id="NP_389237.1" /db_xref="EnsemblGenomes-Gn:BSU13540" /db_xref="EnsemblGenomes-Tr:CAB13227" /db_xref="GOA:P11742" /db_xref="InterPro:IPR001497" /db_xref="InterPro:IPR008332" /db_xref="InterPro:IPR014048" /db_xref="InterPro:IPR023546" /db_xref="InterPro:IPR036217" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036631" /db_xref="SubtiList:BG10848" /db_xref="UniProtKB/Swiss-Prot:P11742" /translation="MNYYTTAETPLGELIIAEEEDRITRLFLSQEDWVDWKETVQNTE HKETPNLAEAKQQLQEYFAGERKTFSLPLSQKGTPFQQKVWQALERIPYGESRSYADI AAAVGSPKAVRAVGQANKRNDLPIFVPCHRVIGKNSALTGYAGSKTEIKAFLLNIERI SYKEK*" /label="ogt CDS" gene 1302621..1303118 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /label="ogt gene" S_feature 1303119..1303358 /Source="Nicolas_S_feature" /locus_tag="new_1421924_1422163" /HighExp="Lbstat, S2, BT, BC, LPhT, dia15, LBGstat, M0t90, M9-stat, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.981549" /TUshortSig="SigA, SigH" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S485" CDS 1303208..1303333 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513954.1" /translation="MKPSRSEKLAVFAELFVKLHILSSAQKDEIINVNKKKQKNR*" /label="hypothetical protein CDS" gene 1303208..1303333 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /label="gene" downshifts 1303326 /Source="Nicolas_upshifts" /id="D744" /incds=0 /nref=80 /ntot=239 /MaxReadThrough="1.90528" /MaxDrop="5.2481" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1303367..1304428) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /EC_number="5.3.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14551435, 15102328, 16511105, 17690466, 18156470" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14551435, 15102328, 16511105, 17690466, 18156470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose-1-phosphate isomerase (methionine salvage pathway)" /protein_id="NP_389238.1" /db_xref="EnsemblGenomes-Gn:BSU13550" /db_xref="EnsemblGenomes-Tr:CAB13228" /db_xref="GOA:O31662" /db_xref="InterPro:IPR000649" /db_xref="InterPro:IPR005251" /db_xref="InterPro:IPR011559" /db_xref="InterPro:IPR027363" /db_xref="PDB:2YRF" /db_xref="PDB:2YVK" /db_xref="SubtiList:BG13278" /db_xref="UniProtKB/Swiss-Prot:O31662" /translation="MTHSFAVPRSVEWKETAITILNQQKLPDETEYLELTTKEDVFDA IVTLKVRGAPAIGITAAFGLALAAKDIETDNVTEFRRRLEDIKQYLNSSRPTAINLSW ALERLSHSVENAISVNEAKTNLVHEAIQIQVEDEETCRLIGQNALQLFKKGDRIMTIC NAGSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLI TDSMAAHTMKEKQISAVIVGADRIAKNGDTANKIGTYGLAILANAFDIPFFVAAPLST FDTKVKCGADIPIEERDPEEVRQISGVRTAPSNVPVFNPAFDITPHDLISGIITEKGI MTGNYEEEIEQLFKGEKVH*" /label="mtnA CDS" gene complement(1303367..1304428) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /label="mtnA gene" downshifts complement(1303384) /Source="Nicolas_upshifts" /id="D745" /incds=0 /nref=261 /ntot=286 /MaxReadThrough="4.47312" /MaxDrop="7.97339" /score="34.04363" /energy="-17.1" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(1304436..1305629) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /EC_number="2.7.1.100" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:210167, 11545674, 15102328, 17522047, 23649237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 210167, 11545674, 15102328, 17522047, 23649237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose kinase (methionine salvage pathway, promiscuous)" /protein_id="NP_389239.2" /db_xref="EnsemblGenomes-Gn:BSU13560" /db_xref="EnsemblGenomes-Tr:CAB13229" /db_xref="GOA:O31663" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR009212" /db_xref="InterPro:IPR011009" /db_xref="PDB:2OLC" /db_xref="PDB:2PU8" /db_xref="PDB:2PUI" /db_xref="PDB:2PUL" /db_xref="PDB:2PUN" /db_xref="PDB:2PUP" /db_xref="SubtiList:BG13279" /db_xref="UniProtKB/Swiss-Prot:O31663" /translation="MGVTKTPLYETLNESSAVALAVKLGLFPSKSTLTCQEIGDGNLN YVFHIYDQEHDRALIIKQAVPYAKVVGESWPLTIDRARIESSALIRQGEHVPHLVPRV FYSDTEMAVTVMEDLSHLKIARKGLIEGENYPHLSQHIGEFLGKTLFYSSDYALEPKV KKQLVKQFTNPELCDITERLVFTDPFFDHDTNDFEEELRPFVEKLWNNDSVKIEAAKL KKSFLTSAETLIHGDLHTGSIFASEHETKVIDPEFAFYGPIGFDVGQFIANLFLNALS RDGADREPLYEHVNQVWETFEETFSEAWQKDSLDVYANIDGYLTDTLSHIFEEAIGFA GCELIRRTIGLAHVADLDTIVPFDKRIGRKRLALETGTAFIEKRSEFKTITDVIELFK LLVKE*" /label="mtnK CDS" gene complement(1304436..1305629) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /label="mtnK gene" downshifts 1304496 /Source="Nicolas_upshifts" /id="D746" /incds=1 /nref=1 /ntot=51 /MaxReadThrough="3.02938" /MaxDrop="3.49719" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts complement(1305716) /Source="Nicolas_upshifts" /id="D747" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="8.61071" /MaxDrop="3.05641" /score="27.7981655" /energy="-17.6" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-2750" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1305722..1305878) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="12: Regulatory functions" /label="mswC RNA" gene complement(1305722..1305878) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /label="mswC gene" promotor_-10 complement(1305913..1305932) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1305914) /Source="Nicolas_upshifts" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1305948..1305955) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1305958..1305961 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1305962..1306741) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /EC_number="3.5.1.3" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12022921, 19464248, 19596042, 21288482, 23944997, 24387040; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ketoglutaramate omega-amidase" /protein_id="NP_389240.1" /db_xref="EnsemblGenomes-Gn:BSU13570" /db_xref="EnsemblGenomes-Tr:CAB13230" /db_xref="GOA:O31664" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG13280" /db_xref="UniProtKB/Swiss-Prot:O31664" /translation="MKWTISCLQFDISYGKPSENIKKAEFFIEKESKHADVLVLPELW TTGYDLANLDELADEDGRSAQSWLKKTAKKHGVHIVAGSVAVRKNSDVYNTMYIADKE GQIIKEYRKAHLFQLMDEHLYLSAGSEDGYFELDGVKSSGLICYDIRFPEWIRKHTTK GANVLFISAEWPLPRLDHWKSLLIARAIENQCFVAACNCTGSNPDNEFAGHSLIIDPW GRVLAEGGREEGIVRAEIDLQESAEVRESIPVFDDIRKDLY*" /label="mtnU CDS" gene complement(1305962..1306741) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /label="mtnU gene" promotor_-10 1305977..1305996 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1305986 /Source="Nicolas_upshifts" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1306434..1306441 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-35" promotor_-10 1306454..1306473 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-10" upshifts 1306469 /Source="Nicolas_upshifts" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="upshifts" S_feature 1306476..1306793 /Source="Nicolas_S_feature" /locus_tag="new_1425281_1425598" /HighExp="LoTm, S8, C30, BC, S7, B36, B60, T2.0H, Sw, UNK1" /AntisenseName="mtnU" /AntisenseCor="0.77659263363209297" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S486" promotor_-35 1306763..1306770 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1306771..1306790) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1306785..1306804 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1306785) /Source="Nicolas_upshifts" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" upshifts 1306795 /Source="Nicolas_upshifts" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1306806..1306813) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1306836..1308032 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /EC_number="2.6.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15102328, 23429746, 24387040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15102328, 23429746, 24387040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine-glutamine aminotransferase" /protein_id="NP_389241.1" /db_xref="EnsemblGenomes-Gn:BSU13580" /db_xref="EnsemblGenomes-Tr:CAB13231" /db_xref="GOA:O31665" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13281" /db_xref="UniProtKB/Swiss-Prot:O31665" /translation="MKFEQSHVLKELPKQFFASLVQKVNRKLAEGHDVINLGQGNPDQ PTPEHIVEEMKRAVADPENHKYSSFRGSYRLKSAAAAFYKREYGIDLDPETEVAVLFG GKAGLVELPQCLLNPGDTILVPDPGYPDYWSGVTLAKAKMEMMPLVKDRAFLPDYSSI TAEIREQAKLMYLNYPNNPTGAVATSEFFEDTVRFAAENGICVVHDFAYGAVGFDGCK PLSFLQTEGAKDIGIEIYTLSKTYNMAGWRVGFAVGNASVIEAINLYQDHMFVSLFRA TQEAAAEALLADQTCVAEQNARYESRRNAWITACREIGWDVTAPAGSFFAWLPVPEGY TSEQFSDLLLEKANVAVAAGNGFGEYGEGYVRVGLLTSEERLKEAAYRIGKLNLFTQK SIDKTL*" /label="mtnE CDS" gene 1306836..1308032 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /label="mtnE gene" promotor_-35 1308014..1308021 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1308036..1308055 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1308055 /Source="Nicolas_upshifts" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1308071..1308171 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="16.3: Control" /label="mswD RNA" gene 1308071..1308171 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /label="mswD gene" downshifts 1308170 /Source="Nicolas_upshifts" /id="D748" /incds=0 /nref=49 /ntot=190 /MaxReadThrough="7.27369" /MaxDrop="4.19981" /score="-1.80590532" /energy="-10.7" /TU="U1103,U1104" /idTUdmin="U1101" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS 1308256..1309473 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /EC_number="5.3.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 16737967, 18403380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 16737967, 18403380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2,3-diketo-5-methylthiopentyl-1-phosphate enolase (DK-MTP-1-P enolase)" /protein_id="NP_389242.2" /db_xref="EnsemblGenomes-Gn:BSU13590" /db_xref="EnsemblGenomes-Tr:CAB13232" /db_xref="GOA:O31666" /db_xref="InterPro:IPR000685" /db_xref="InterPro:IPR017443" /db_xref="InterPro:IPR017717" /db_xref="InterPro:IPR033966" /db_xref="InterPro:IPR036376" /db_xref="InterPro:IPR036422" /db_xref="PDB:2ZVI" /db_xref="SubtiList:BG13282" /db_xref="UniProtKB/Swiss-Prot:O31666" /translation="MSELLATYLLTEPGADTEKKAEQIATGLTVGSWTDLPLVKQEQM QKHKGRVIKVEEREGTAASEKQAVITIAYPEINFSQDIPALLTTVFGKLSLDGKIKLI DLHFSEAFKRALPGPKFGVYGIRKLLGEFERPLLMSIFKGVIGRDLSDIKEQLRQQAL GGVDLIKDDEIFFETGLAPFETRIAEGKQILKETYEQTGHKTLYAVNLTGRTADLKDK ARRAAELGADALLFNVFAYGLDVMQGLAEDPEIPVPIMAHPAVSGAFTSSPFYGFSHA LLLGKLNRYCGADFSLFPSPYGSVALPRADALAIHEECVREDAFNQTFAVPSAGIHPG MVPLLMRDFGIDHIINAGGGVHGHPNGAQGGGRAFRAIIDAVLEAQPIDEKAEQCKDL KLALDKWGKAEAV*" /label="mtnW CDS" gene 1308256..1309473 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /label="mtnW gene" CDS 1309470..1310177 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /EC_number="3.1.3.87" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 17654724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 17654724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphatephosphatase (HK-MTPenyl-1-P phosphatase)" /protein_id="NP_389243.1" /db_xref="EnsemblGenomes-Gn:BSU13600" /db_xref="EnsemblGenomes-Tr:CAB13233" /db_xref="GOA:O31667" /db_xref="InterPro:IPR006384" /db_xref="InterPro:IPR017718" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:2FEA" /db_xref="SubtiList:BG13283" /db_xref="UniProtKB/Swiss-Prot:O31667" /translation="MTTRKPFIICDFDGTITMNDNIINIMKTFAPPEWMALKDGVLSK TLSIKEGVGRMFGLLPSSLKEEITSFVLEDAKIREGFREFVAFINEHEIPFYVISGGM DFFVYPLLEGIVEKDRIYCNHASFDNDYIHIDWPHSCKGTCSNQCGCCKPSVIHELSE PNQYIIMIGDSVTDVEAAKLSDLCFARDYLLNECREQNLNHLPYQDFYEIRKEIENVK EVQEWLQNKNAGESSLK*" /label="mtnX CDS" gene 1309470..1310177 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /label="mtnX gene" CDS 1310135..1310764 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /EC_number="4.2.1.109" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 18391471, 23285211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 18391471, 23285211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)" /protein_id="NP_389244.1" /db_xref="EnsemblGenomes-Gn:BSU13610" /db_xref="EnsemblGenomes-Tr:CAB13234" /db_xref="GOA:O31668" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR017714" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG13284" /db_xref="UniProtKB/Swiss-Prot:O31668" /translation="MAAKQERWRELAEVKRELAERDWFPATSGNLSIKVTDEPLTFLV TASGKDKRKETVEDFLLVDQNGEPAESGHSLKPSAETLLHTHLYNKTNAGCCLHVHTV NNNVISELYGDQKKITFKGQEIIKALGLWEENAEVTVPIIENPAHIPTLAALFAEEIS EDSGAVLIRNHGITAWGKTAFEAKRVLEAYEFLFSYHLKLKTLEHQLVK*" /label="mtnB CDS" gene 1310135..1310764 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /label="mtnB gene" CDS 1310779..1311315 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /EC_number="1.13.11.54" /EC_number="1.13.11.53" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acireductone dioxygenase (Ni2+ or Fe2+-requiring)" /protein_id="NP_389245.1" /db_xref="EnsemblGenomes-Gn:BSU13620" /db_xref="EnsemblGenomes-Tr:CAB13235" /db_xref="GOA:O31669" /db_xref="InterPro:IPR004313" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR023956" /db_xref="SubtiList:BG13285" /db_xref="UniProtKB/Swiss-Prot:O31669" /translation="MATIRIHDEANTTIENQEEVASFLDSQEVIYEQWDITRLPEHLS EKYDLTEEEKQQILDTFETEIKDISTRRGYKAQDVISLSDSNPKLDELLENFKREHHH TDDEVRFIVSGHGIFVIQGQDGTFFDVRLNPGDLISVPENIRHYFTLQEDRKVVAVRI FVTTEGWVPIYEKDSVNQ*" /label="mtnD CDS" gene 1310779..1311315 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /label="mtnD gene" S_feature complement(1311162..1311355) /Source="Nicolas_S_feature" /locus_tag="new_1429967_1430160_c" /HighExp="Lbstat, Cold, LBGstat, T0.30H, M9-stat, B60, ferm, T1.30H, LPhT, M0t90" /AntisenseName="mtnD" /AntisenseCor="-0.31139057410816301" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S487" downshifts 1311315 /Source="Nicolas_upshifts" /id="D749" /incds=0 /nref=179 /ntot=227 /MaxReadThrough="1.58976" /MaxDrop="6.10661" /score="35.4563733" /energy="-14.9" /TU="NA" /idTUdmin="U1103" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1311356..1311676) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389246.1" /db_xref="EnsemblGenomes-Gn:BSU13630" /db_xref="EnsemblGenomes-Tr:CAB13236" /db_xref="GOA:O31670" /db_xref="InterPro:IPR010652" /db_xref="SubtiList:BG13308" /db_xref="UniProtKB/Swiss-Prot:O31670" /translation="MKKKKAIMLGAAGGKAILKRKNRKKCIQHITTFFQMLRDWRNGD YPRSQVKTLLLLTAAILYIVMPLDIIPDVILGLGFIDDAAVLGLIWTLIKKELSQYEK WRLQ*" /label="ykvA CDS" gene complement(1311356..1311676) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /label="ykvA gene" downshifts complement(1311414) /Source="Nicolas_upshifts" /id="D750" /incds=0 /nref=5 /ntot=148 /MaxReadThrough="4.05831" /MaxDrop="2.74575" /score="18.5455371" /energy="-11.3" /TU="U1106" /idTUdmin="U1106" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(1311677..1311766) /Source="Nicolas_S_feature" /locus_tag="new_1430482_1430571_c" /HighExp="Lbstat, M9-stat, B60, T0.30H, LBGstat, M0t90, T1.0H, S2, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S488" promotor_-35 1311702..1311708 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1311723..1311741 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1311733 /Source="Nicolas_upshifts" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" S_feature 1311734..1311818 /Source="Nicolas_S_feature" /locus_tag="new_1430539_1430623" /HighExp="Etha, Gly, BC, Salt, Sw, B60, LoTm, M9-stat, LPhT, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S489" promotor_-10 complement(1311748..1311767) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1311765) /Source="Nicolas_upshifts" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1311782..1311785) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1311792..1311799 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1311814..1311833 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1311820..1311878 /Source="Nicolas_S_feature" /locus_tag="new_1430625_1430683" /HighExp="Etha, Gly, Sw, BC, LoTm, B36, T3.30H, Salt, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S490" upshifts 1311820 /Source="Nicolas_upshifts" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1311876) /Source="Nicolas_upshifts" /id="D751" /incds=0 /nref=3 /ntot=61 /MaxReadThrough="0.87927" /MaxDrop="3.53961" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1106" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1311879..1312136 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15057450, 15916600, 17001075, 19332814, 22524514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15057450, 15916600, 17001075, 19332814, 22524514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="negative regulatory phosphatase acting on Spo0A-P (sporulation)" /protein_id="NP_389247.1" /db_xref="EnsemblGenomes-Gn:BSU13640" /db_xref="EnsemblGenomes-Tr:CAB13237" /db_xref="GOA:P05043" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG10769" /db_xref="UniProtKB/Swiss-Prot:P05043" /translation="MGGSSEQERLLVSIDEKRKLMIDAARKQGFTGHDTIRHSQELDC LINEYHQLMQENEHSQGIQGLVKKLGLWPRRDVMPAYDANK*" /label="spo0E CDS" gene 1311879..1312136 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /label="spo0E gene" downshifts 1312130 /Source="Nicolas_upshifts" /id="D752" /incds=0 /nref=7 /ntot=169 /MaxReadThrough="4.39402" /MaxDrop="3.59614" /score="0.224700481" /energy="-5.9" /TU="U1105,U1107" /idTUdmin="U1105" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS 1312222..1312653 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative small membrane protein" /protein_id="NP_389248.1" /db_xref="EnsemblGenomes-Gn:BSU13650" /db_xref="EnsemblGenomes-Tr:CAB13238" /db_xref="GOA:P06630" /db_xref="SubtiList:BG10770" /db_xref="UniProtKB/Swiss-Prot:P06630" /translation="MKELAILITEMVNQFHDAFISLCGIFGIHLTDKEMHFWVIGIFG IFFFGVTHAVFTWLSKWSMTALSFIYTVTVIIVIVFAIEIQQKVTGRGNMEFLDATEG IKGFLVFFMFFLLLKMLLRFIKILFSGRPASKSNGNARSRR*" /label="eag CDS" gene 1312222..1312653 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /label="eag gene" CDS complement(1312681..1314201) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /EC_number="2.7.13.3" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine kinase phosphorylating Spo0A" /protein_id="NP_389249.1" /db_xref="EnsemblGenomes-Gn:BSU13660" /db_xref="EnsemblGenomes-Tr:CAB13239" /db_xref="GOA:O31671" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4JGO" /db_xref="PDB:4JGP" /db_xref="PDB:4JGQ" /db_xref="PDB:4JGR" /db_xref="SubtiList:BG13309" /db_xref="UniProtKB/Swiss-Prot:O31671" /translation="MLERCKLKILKGACGRVKLYIILVVIPAIVISFFVYEKEKDTIA AEHKQEASVLLNLHRNKINYLIGETMARMTSLSIAIDRPVDIKKMQSILEKTFDSEPR FSGLYFLNAKGDVTASTTELKTKVNLADRSFFIKAKETKKTVISDSYSSRITGQPIFT ICVPVLDSKRNVTDYLVAAIQIDYLKNLINLLSPDVYIEVVNQDGKMIFASGQASHAE DQKPVSGYLDDISWNMKVYPNPVTIEELSKSLVLPLSCIIVLLNILFILVLYYLLKRQ TQLERSENEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQLYFSIIE QEIKRINQIVSEFLVLGKPTAEKWELNSLQDIIGEIMPIIYSEGNLYNVEVELQYLTE QPLLVKCTKDHIKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQE MLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPVSAS*" /label="kinD CDS" gene complement(1312681..1314201) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /label="kinD gene" downshifts complement(1312693) /Source="Nicolas_upshifts" /id="D753" /incds=0 /nref=106 /ntot=227 /MaxReadThrough="0.62895" /MaxDrop="5.24795" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1109" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1313402..1313408 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1313422..1313433 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1313428 /Source="Nicolas_upshifts" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1314209..1314228) /Source="Nicolas_upshift_promotors" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1314230) /Source="Nicolas_upshifts" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1314328..1314335 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1314350..1314369 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1314352 /Source="Nicolas_upshifts" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="upshifts" CDS 1314394..1314831 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17725564, 17962296, 18282125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17725564, 17962296, 18282125; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family)" /protein_id="NP_389250.1" /db_xref="EnsemblGenomes-Gn:BSU13670" /db_xref="EnsemblGenomes-Tr:CAB13240" /db_xref="GOA:O31672" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13310" /db_xref="UniProtKB/Swiss-Prot:O31672" /translation="MTEKSLKLFIVLSRAYRSINDHMNKHIHKHGLNPTEFAVLELLY HKGDQPLQQIGDKILLASGSITYVVDKLEQKELLIRKASPTDRRVTFAQITEKGIGLL NDIFPDHAAEIDEMISVLSEEEVEMCTEMLKRVGLNAKQFHNK*" /label="mhqR CDS" gene 1314394..1314831 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /label="mhqR gene" downshifts 1314814 /Source="Nicolas_upshifts" /id="D754" /incds=0 /nref=210 /ntot=257 /MaxReadThrough="1.20686" /MaxDrop="5.47215" /score="1.59181784" /energy="-8.9" /TU="U1110" /idTUdmin="U1110" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1314871..1315656) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein B; MotB component of the H+-coupled stator flagellum complex" /protein_id="NP_389251.1" /db_xref="EnsemblGenomes-Gn:BSU13680" /db_xref="EnsemblGenomes-Tr:CAB13241" /db_xref="GOA:P28612" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10689" /db_xref="UniProtKB/Swiss-Prot:P28612" /translation="MARKKKKKHEDEHVDESWLVPYADILTLLLALFIVLYASSSIDA AKFQMLSKSFNEVFTGGTGVLDYSSVTPPENESDGIDEVKKEKEEKEKNKKEKEKAAD QEELENVKSQVEKFIKDKKLEHQLETKMTSEGLLITIKDSIFFDSGKATIRKEDVPLA KEISNLLVINPPRNIIISGHTDNMPIKNSEFQSNWHLSVMRAVNFMGLLIENPKLDAK VFSAKGYGEYKPVASNKTAEGRSKNRRVEVLILPRGAAETNEK*" /label="motB CDS" gene complement(1314871..1315656) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /label="motB gene" downshifts complement(1314890) /Source="Nicolas_upshifts" /id="D755" /incds=0 /nref=224 /ntot=246 /MaxReadThrough="3.05351" /MaxDrop="6.69306" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(1315352) /Source="Nicolas_upshifts" /id="D756" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="8.03566" /MaxDrop="4.69358" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(1315628..1316440) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein A; MotA component of the H+-coupled stator flagellum complex" /protein_id="NP_389252.1" /db_xref="EnsemblGenomes-Gn:BSU13690" /db_xref="EnsemblGenomes-Tr:CAB13242" /db_xref="GOA:P28611" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10688" /db_xref="UniProtKB/Swiss-Prot:P28611" /translation="MDKTSLIGIILAFVALSVGMVLKGVSFSALANPAAILIIIAGTI SAVVIAFPTKEIKKVPTLFRVLFKENKQLTIEELIPMFSEWAQLARREGLLALEASIE DVDDAFLKNGLSMAVDGQSAEFIRDIMTEEVEAMEDRHQAGAAIFTQAGTYAPTLGVL GAVIGLIAALSHMDNTDELGHAISAAFVATLLGIFTGYVLWHPFANKLKRKSKQEVKL REVMIEGVLSVLEGQAPKVIEQKLLMYLPAKDRLKFAEQGEAQNGEKKEEEA*" /label="motA CDS" gene complement(1315628..1316440) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /label="motA gene" promotor_-10 complement(1316471..1316489) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1316487) /Source="Nicolas_upshifts" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1316503..1316510) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1316578..1316800) /Source="Nicolas_S_feature" /locus_tag="new_1435383_1435605_c" /HighExp="Diami, dia15, dia5, Heat, Etha, LPhT, H2O2, C30, G135, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.93062599999999995" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S491" downshifts complement(1316610) /Source="Nicolas_upshifts" /id="D757" /incds=0 /nref=5 /ntot=12 /MaxReadThrough="0.48394" /MaxDrop="4.60081" /score="30.9355071" /energy="-15.4" /TU="NA" /idTUdmin="U1112" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1316823..1318922) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease (class III stress gene)" /protein_id="NP_389253.1" /db_xref="EnsemblGenomes-Gn:BSU13700" /db_xref="EnsemblGenomes-Tr:CAB13243" /db_xref="GOA:O31673" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="SubtiList:BG12578" /db_xref="UniProtKB/Swiss-Prot:O31673" /translation="MRCQHCHQNEATIRLNMQINSVHKQMVLCETCYNELTRKPSMSM GPQSFGFPFEQAFQPKEQSAAKQSEKKGLLDELAQNITNGAKAGLIDPVIGRDDEVAR VIEILNRRNKNNPVLIGEPGVGKTAIAEGLALKIAEGDVPNKLKNKELYLLDVASLVA NTGIRGQFEERMKQLITELKERKNVILFIDEIHLLVGAGSAEGSMDAGNILKPALARG ELQVIGATTLKEYRQIEKDAALERRFQPVMVQEPSIEQAILILQGIKDKYEAYHGVTF SDEAIKACVTLSSRYIQDRHLPDKAIDLLDEAGSKANLLIDELNDEDAAERLTAIEAE KTKALEEENYELAAKLRDEELALEKKLNSSSAHTAVTVEAEHIQEIVEQKTGIPVGKL QADEQTKMKELEAKLHERVIGQEAAVQKVAKAVRRSRAGLKSKNRPVGSFLFVGPTGV GKTELSKTLADELFGTKDAIIRLDMSEYMEKHAVSKIIGSPPGYVGHEEAGQLTEKVR RNPYSIVLLDEIEKAHPDVQHMFLQIMEDGRLTDSQGRTVSFKDTVIIMTSNAGAGEK QTKVGFQSDDSVIEEQTLIDSLSMFFKPEFLNRFDSIIEFRSLEKEHLVKIVSLLLGE LEETLAERGISLNVTDEAKEKIAELGYHPSFGARPLRRTIQEWVEDEMTDLLLDNGEI TSFHVILEDDKIKVRAK*" /label="clpE CDS" gene complement(1316823..1318922) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /label="clpE gene" downshifts complement(1316845) /Source="Nicolas_upshifts" /id="D758" /incds=0 /nref=27 /ntot=132 /MaxReadThrough="4.1802" /MaxDrop="6.07862" /score="41.2563375" /energy="-13.6" /TU="U1112" /idTUdmin="U1112" /TUdmin="-239" /isTUend="FALSE" /label="downshifts" S_feature complement(1318923..1319173) /Source="Nicolas_S_feature" /locus_tag="new_1437728_1437978_c" /HighExp="dia5, Heat, Diami, LPhT, dia15, H2O2, HiTm, S2, Cold, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S492" promotor_no_box complement(1319133..1319233) /Source="Nicolas_upshift_promotors" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1319173) /Source="Nicolas_upshifts" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1319209..1319214 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1319224 /Source="Nicolas_upshifts" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1319230..1319248 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1319287..1320330 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389254.1" /db_xref="EnsemblGenomes-Gn:BSU13710" /db_xref="EnsemblGenomes-Tr:CAB13244" /db_xref="GOA:O31674" /db_xref="SubtiList:BG13311" /db_xref="UniProtKB/Swiss-Prot:O31674" /translation="MEQSKGSASQLAFVYVGTVVGAGFATGREIVEFFLKFGWFGFFG ILVSGGMFTLLGAKLMIISKRINAKSYQEMNIFLFGATAGRIINVFMLFVLLGVTSVM LSGAGALFEEQLGMSAQIGMLITIGLSLIVMTRGVKGIFGVNVFVVPLLIIFSMIVVA DSFIFSESRNAAQWVWPHRWDWLLSAVSYGALNLSLAQAVLVPLANEMSSEKVIKKGA LIGGTMLTIVLSASFLSLSTLPDVFLYDIPMAQVVYLFARSVHLIYLLIIFGEVFTSV IGNLYGLEKQVQSFLPVKSKYIFAAIMITAYITSQIGYGRLISTIYPLFGYVSLAFIG ALLCKKAPRRRSL*" /label="ykvI CDS" gene 1319287..1320330 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /label="ykvI gene" S_feature 1320331..1320422 /Source="Nicolas_S_feature" /locus_tag="new_1439136_1439227" /HighExp="S3, LoTm, S4, S5, BT, M9-stat, S6, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S493" promotor_-35 1320399..1320403 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1320420..1320439 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1320424 /Source="Nicolas_upshifts" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1320469..1320513 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /product="preQ1 riboswitch" /experiment="publication(s) with functional evidences, PMID:17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311; Product type n: RNA" /function="16.3: Control" /label="qswA RNA" gene 1320469..1320513 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /label="qswA gene" downshifts 1320490 /Source="Nicolas_upshifts" /id="D759" /incds=0 /nref=11 /ntot=17 /MaxReadThrough="7.29177" /MaxDrop="4.09959" /score="21.1398563" /energy="-9.5" /TU="U1114" /idTUdmin="U1113" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1320535..1320642 /Source="Nicolas_S_feature" /locus_tag="new_1439340_1439447" /HighExp="Paraq, ferm, G180, LBGstat, Diami, H2O2, LPhT, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S494" CDS 1320643..1321302 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /EC_number="6.3.4.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14660578, 16199558, 17384645, 18491386, 19354300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14660578, 16199558, 17384645, 18491386, 19354300; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pre-queuosine 0 synthase" /protein_id="NP_389255.1" /db_xref="EnsemblGenomes-Gn:BSU13720" /db_xref="EnsemblGenomes-Tr:CAB13245" /db_xref="GOA:O31675" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018317" /db_xref="PDB:3BL5" /db_xref="SubtiList:BG13312" /db_xref="UniProtKB/Swiss-Prot:O31675" /translation="MKKEKAIVVFSGGQDSTTCLLWALKEFEEVETVTFHYNQRHSQE VEVAKSIAEKLGVKNHLLDMSLLNQLAPNALTRNDIEIEVKDGELPSTFVPGRNLVFL SFASILAYQIGARHIITGVCETDFSGYPDCRDEFVKSCNVTVNLAMEKPFVIHTPLMW LNKAETWKLADELGALDFVKNNTLTCYNGIIADGCGECPACHLRSKGYEEYMVMKGER A*" /label="queC CDS" gene 1320643..1321302 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /label="queC gene" CDS 1321295..1321744 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /EC_number="4.1.2.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 18259064, 19231875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 18259064, 19231875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-carboxy-5,6,7,8-tetrahydropterin synthase; queuosine biosynthesis" /protein_id="NP_389256.1" /db_xref="EnsemblGenomes-Gn:BSU13730" /db_xref="EnsemblGenomes-Tr:CAB13246" /db_xref="GOA:O31676" /db_xref="InterPro:IPR007115" /db_xref="SubtiList:BG13313" /db_xref="UniProtKB/Swiss-Prot:O31676" /translation="MHKLLSQIYPQAQHPYSFELNKDMHISAAHFIPRESAGACSRVH GHTYTVNITVAGDELDDSGFLVNFSVLKKLVHGNYDHTLLNDHEDFSQDDRYSLPTTE VVAKTIYDNVQAYLDTLENKPTCVQVFVRETPTSYCVYRPKKGGLNG*" /label="queD CDS" gene 1321295..1321744 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /label="queD gene" CDS 1321737..1322468 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /EC_number="4.3.99.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 19354300, 23194065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 19354300, 23194065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-carboxy-7-deazaguanine synthase" /protein_id="NP_389257.1" /db_xref="EnsemblGenomes-Gn:BSU13740" /db_xref="EnsemblGenomes-Tr:CAB13247" /db_xref="GOA:O31677" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR017742" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR024924" /db_xref="PDB:5TGS" /db_xref="PDB:5TH5" /db_xref="SubtiList:BG13314" /db_xref="UniProtKB/Swiss-Prot:O31677" /translation="MAKGIPVLEIFGPTIQGEGMVIGQKTMFVRTAGCDYSCSWCDSA FTWDGSAKKDIRWMTAEEIFAELKDIGGDAFSHVTISGGNPALLKQLDAFIELLKENN IRAALETQGTVYQDWFTLIDDLTISPKPPSSKMVTNFQKLDHILTSLQENDRQHAVSL KVVIFNDEDLEFAKTVHKRYPGIPFYLQVGNDDVHTTDDQSLIAHLLGKYEALVDKVA VDAELNLVRVLPQLHTLLWGNKRGV*" /label="queE CDS" gene 1321737..1322468 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /label="queE gene" CDS 1322486..1322983 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /EC_number="1.7.1.13" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent 7-cyano-7-deazaguanine reductase" /protein_id="NP_389258.1" /db_xref="EnsemblGenomes-Gn:BSU13750" /db_xref="EnsemblGenomes-Tr:CAB13248" /db_xref="GOA:O31678" /db_xref="InterPro:IPR016856" /db_xref="InterPro:IPR029500" /db_xref="PDB:4F8B" /db_xref="PDB:4FGC" /db_xref="PDB:5UDG" /db_xref="SubtiList:BG13315" /db_xref="UniProtKB/Swiss-Prot:O31678" /translation="MTTRKESELEGVTLLGNQGTNYLFEYAPDVLESFPNKHVNRDYF VKFNCPEFTSLCPKTGQPDFATIYISYIPDEKMVESKSLKLYLFSFRNHGDFHEDCMN IIMNDLIELMDPRYIEVWGKFTPRGGISIDPYTNYGKPGTKYEKMAEYRMMNHDLYPE TIDNR*" /label="queF CDS" gene 1322486..1322983 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /label="queF gene" S_feature 1322984..1323260 /Source="Nicolas_S_feature" /locus_tag="new_1441789_1442065" /HighExp="Paraq, ferm, LPhT, C30, G135, G180, LBGstat, Oxctl, G150, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S495" downshifts 1323218 /Source="Nicolas_upshifts" /id="D760" /incds=0 /nref=200 /ntot=247 /MaxReadThrough="1.17154" /MaxDrop="6.60953" /score="11.1883045" /energy="-7.8" /TU="NA" /idTUdmin="U1114" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1323228) /Source="Nicolas_upshifts" /id="D761" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.54726" /MaxDrop="2.16508" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=110 /isTUend="FALSE" /label="downshifts" S_feature complement(1323297..1323541) /Source="Nicolas_S_feature" /locus_tag="new_1442102_1442346_c" /HighExp="Diami, dia5, LPhT, Etha, Salt, dia15, Heat, HiTm, C30, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15795400000000001" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S496" downshifts complement(1323338) /Source="Nicolas_upshifts" /id="D762" /incds=0 /nref=47 /ntot=193 /MaxReadThrough="2.13712" /MaxDrop="5.08206" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1323542..1323898) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HGT island)" /protein_id="NP_389259.1" /db_xref="EnsemblGenomes-Gn:BSU13760" /db_xref="EnsemblGenomes-Tr:CAB13249" /db_xref="GOA:O31679" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13316" /db_xref="UniProtKB/Swiss-Prot:O31679" /translation="MKKFSCGFEVTKEVIGGKWKGLVLYFLMNGPKRTSELKRIIPNI TQKMLIQTLRELEASGLVSRKMYNQVPPKVEYSSTELGESLKPILQELCQWGGYYAEQ EYAEGEYEIVQPEQLS*" /label="ykvN CDS" gene complement(1323542..1323898) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /label="ykvN gene" misc_feature complement(1323929..1323948) /Source="Nicolas_upshift_promotors" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1323946) /Source="Nicolas_upshifts" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1323983..1324001 /Source="Nicolas_upshift_promotors" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1323988 /Source="Nicolas_upshifts" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="upshifts" CDS 1324067..1324813 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018, 26494135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (HGT island)" /protein_id="NP_389260.1" /db_xref="EnsemblGenomes-Gn:BSU13770" /db_xref="EnsemblGenomes-Tr:CAB13250" /db_xref="GOA:O31680" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13317" /db_xref="UniProtKB/Swiss-Prot:O31680" /translation="MGKFEGKIALVTGGTSGIGLATAQKFVNEGAYVYITGRRQNELD KAVNQIGKNVTGVQGDISKLEDLDKLYDIIKQEKGKLDILFANAGIGNFLPLGEITEE QVDRTFDINVKGTIFTVQKALSLFPDKVGSIIVTGSTAGSIGNPAFSVYGASKAALRA LVRNWILDLKGTEIRVNVVSPGGILTPAYDELFGDALEEVLENSRNTVPAGKVGTPEE VANAVSFLASDESSYLTGVELFVDGGLAQV*" /label="ykvO CDS" gene 1324067..1324813 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /label="ykvO gene" downshifts 1324868 /Source="Nicolas_upshifts" /id="D763" /incds=0 /nref=19 /ntot=146 /MaxReadThrough="0.723690000000001" /MaxDrop="4.37163" /score="1.34631843" /energy="-9.1" /TU="NA" /idTUdmin="U1116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1325216..1325224 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1325238..1325257 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1325242 /Source="Nicolas_upshifts" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="upshifts" CDS 1325294..1326493 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11011148, 16683018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16683018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein (HGT island)" /protein_id="NP_389261.1" /db_xref="EnsemblGenomes-Gn:BSU13780" /db_xref="EnsemblGenomes-Tr:CAB13251" /db_xref="GOA:O31681" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13318" /db_xref="UniProtKB/Swiss-Prot:O31681" /translation="MKILFLESHPMWLYGLPNGFREAGHTVMISGPVSRENITEMIDE FKPDLIVSMGWTPEHSREKQAWIRNATKKVNIPLVYWATEDPLHTQNFTIPLIKKMKP DFVFTVTPSLCKTYESMGIKAAHLDFAFHESIHHQIKPLAKYSCDIAVVANAYPNFLE EHPEVFRSSSLKTLIRPLIRKGIRIDFWGRNWEKMSKYIGREIPRNWIHGYLDYTEAY KVYSSAKIIIGLQNCESQLTQRTYEILGSGGFLLTSDTPAVRGKFKPGRDLIVSSSPK ETLEKVKYYLNHDSERKKIQINGKKAVKNDSYRHRAERMLEVLKSRGIIRNLGETIHY VDVLKEKYVIHHVTPGETLSIIASKYNVSLQQLMELNHFKSDQIYAGQIIKIREKLFR NINNKLF*" /label="ykvP CDS" gene 1325294..1326493 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /label="ykvP gene" promotor_-35 1325376..1325382 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1325397..1325415 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1325403 /Source="Nicolas_upshifts" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1326462..1326464 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1326484..1326502 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1326496 /Source="Nicolas_upshifts" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1326509..1326736 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative peptidoglycan binding protein" /protein_id="YP_003097719.1" /db_xref="EnsemblGenomes-Gn:BSU13789" /db_xref="EnsemblGenomes-Tr:CAX52610" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="UniProtKB/Swiss-Prot:C0H403" /translation="MKGKIPKIRNQANKVKRTPRYMEFPVTYEVYHVESGDTLWTIAK SFEIPVQQLMNLNKLSSDRIYPGQIIKIRER*" /label="ykzQ CDS" gene 1326509..1326736 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /label="ykzQ gene" misc_feature complement(1326586..1326605) /Source="Nicolas_upshift_promotors" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1326594) /Source="Nicolas_upshifts" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1326737..1326832 /Source="Nicolas_S_feature" /locus_tag="new_1445542_1445637" /HighExp="BT, S8, B36, S7, Etha, S6, G/S, LBGstat, Pyr, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigK" /TUshortPSig="0.602, 0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S497" CDS 1326833..1327531 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /EC_number="3.2.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative sporulation-specific glycosylase (HGT island)" /db_xref="EnsemblGenomes-Gn:BSU13790" /db_xref="EnsemblGenomes-Tr:CAB13252" /db_xref="GOA:O31682" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAB13252.1" /db_xref="SubtiList:BG13319" /db_xref="UniProtKB/Swiss-Prot:O31682" /translation="MFQMSYYYSGLGWDFIQHVDQTNGVLNVVSPDFFYIRKDGSLLL RSANPDVIKALHRRKLKVVPFLSNHWDQDLGRFALMNRVLLAKQISHAIEELDLDGVN IDIENLTEKDRNLFTDFIRLVRKSIPRHKEVSVAVAANPFGWTKGWHGSYDYEYLAKY ADYLMVMAYDESRLAGPTASVGWVEKSIQYVLTQKISPQKLVLGLPFYGRCWMEGQSA SQAIPLYLVVSKKA*" /label="ykvQ CDS" gene 1326833..1327531 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /pseudo /label="ykvQ gene" S_feature complement(1327484..1328310) /Source="Nicolas_S_feature" /locus_tag="new_1446289_1447115_c" /HighExp="H2O2, M40t90, S8, M40t45, LPhT, Sw, Cold, LBGstat, C30, dia15" /AntisenseName="ykzR" /AntisenseCor="0.170402182980955" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="0.38670900000000002" /TUshortSig="SigA" /TUshortPSig="0.986" /TUlongSig="NA" /TUlongPSig="NA" /label="S498" CDS 1327512..1327763 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative spore-specific glycosyl hydrolase" /db_xref="EnsemblGenomes-Gn:BSU13799" /db_xref="EnsemblGenomes-Tr:CAX52611" /db_xref="GOA:C0H404" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAX52611.1" /db_xref="UniProtKB/Swiss-Prot:C0H404" /translation="MLVKRHSGTIIFDTKSQSPKAIFTVNHDKKGPLPSGTYTLWFEN EQSLRAKIKLAQKYNLKGLGSWSLGQEDASVWNTVFKNI*" /label="ykzR CDS" gene 1327512..1327763 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /pseudo /label="ykzR gene" misc_feature 1328013..1328028 /Source="Nicolas_upshift_promotors" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1328036..1328247 /Source="Nicolas_S_feature" /locus_tag="new_1446841_1447052" /HighExp="Diami, S8, dia15, G180, HPh, C30, Paraq, H2O2, Salt, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.516" /TUlongSig="NA" /TUlongPSig="NA" /label="S499" upshifts 1328036 /Source="Nicolas_upshifts" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="upshifts" downshifts 1328212 /Source="Nicolas_upshifts" /id="D764" /incds=0 /nref=2 /ntot=72 /MaxReadThrough="2.59168" /MaxDrop="2.74537" /score="-4.38958816" /energy="-9" /TU="NA" /idTUdmin="U1121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1328299..1328318) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1328321) /Source="Nicolas_upshifts" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1328334..1328341) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1328386..1328393 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1328408..1328427 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1328410 /Source="Nicolas_upshifts" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="upshifts" CDS 1328446..1328736 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="NP_389263.1" /db_xref="EnsemblGenomes-Gn:BSU13800" /db_xref="EnsemblGenomes-Tr:CAB13253" /db_xref="InterPro:IPR021596" /db_xref="InterPro:IPR023105" /db_xref="PDB:2JN9" /db_xref="SubtiList:BG13320" /db_xref="UniProtKB/Swiss-Prot:O31683" /translation="MKTLRLNNVTLEMAAYQEESEPKRKIAFTLNVTSETYHDIAVLL YEKTFNVEVPERDLAFRGEMTNYSTSLTNLYEPGAVSEFYIEITEIDKNADS*" /label="ykvR CDS" gene 1328446..1328736 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /label="ykvR gene" S_feature complement(1328773..1328856) /Source="Nicolas_S_feature" /locus_tag="new_1447578_1447661_c" /HighExp="Etha, dia5, Salt, SMMPr, Lbtran, dia15, Heat, S4, HiOs, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S500" downshifts complement(1328816) /Source="Nicolas_upshifts" /id="D765" /incds=0 /nref=216 /ntot=257 /MaxReadThrough="2.80569" /MaxDrop="6.83857" /score="21.3524751" /energy="-9.9" /TU="U1124" /idTUdmin="U1126" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1328857..1329042) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (HGT island)" /protein_id="NP_389264.2" /db_xref="EnsemblGenomes-Gn:BSU13810" /db_xref="EnsemblGenomes-Tr:CAB13254" /db_xref="InterPro:IPR018690" /db_xref="SubtiList:BG13321" /db_xref="UniProtKB/Swiss-Prot:O31684" /translation="MKIAKVGNVIEFKNGLTGVVEKVNENSVIVDVTIMDNYRDLELD SLTVVNHKNYKIIRDSY*" /label="ykvS CDS" gene complement(1328857..1329042) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /label="ykvS gene" promotor_-10 complement(1329075..1329094) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1329086) /Source="Nicolas_upshifts" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1329088..1329432) /Source="Nicolas_S_feature" /locus_tag="new_1447893_1448237_c" /HighExp="S4, S8, S6, S5, S3, T5.0H, LoTm, S7, T4.0H, BT" /AntisenseName="ykzS" /AntisenseCor="-0.65556958045860303" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S501" promotor_-35 complement(1329108..1329115) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1329141..1329146 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1329162..1329181 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1329169 /Source="Nicolas_upshifts" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="upshifts" CDS 1329208..1329402 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="YP_003097721.1" /db_xref="EnsemblGenomes-Gn:BSU13819" /db_xref="EnsemblGenomes-Tr:CAX52612" /db_xref="UniProtKB/Swiss-Prot:C0H405" /translation="MRPEEITEMIEQLRTGAINELRVQKEHFLDFRAVLSKQDDFKHF RGIAQQGGDVIFQYLEQPRS*" /label="ykzS CDS" gene 1329208..1329402 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /label="ykzS gene" downshifts 1329378 /Source="Nicolas_upshifts" /id="D766" /incds=0 /nref=6 /ntot=124 /MaxReadThrough="3.66738" /MaxDrop="3.03929" /score="5.82604583" /energy="-10.6" /TU="U1125" /idTUdmin="U1123" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1329423..1329441) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1329439) /Source="Nicolas_upshifts" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1329458..1329463) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1329701..1330327 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12177332, 12950927, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall hydrolase related to spore cortex-lytic enzymes" /protein_id="NP_389265.1" /db_xref="EnsemblGenomes-Gn:BSU13820" /db_xref="EnsemblGenomes-Tr:CAB13255" /db_xref="GOA:O31685" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG13322" /db_xref="UniProtKB/Swiss-Prot:O31685" /translation="MTTKFTALAVFLLCFMPAAKIEHTQASLLSAKKTKHEEAKWLTH IDRNTNESFPSLSADKDKKIKPIKLSAHTEKKEKDKPDKTNDEKETYTQSEKELLSRL VHAEAKGESYKGKVAVASVVLNRTEKKGFPDTIRGVIYQKNAFEPVANGSINQKPDKE SIEAAEEALSSKNRETDAIFFYNPKTASDNWIRSRKIVEKIGRHVFAV*" /label="ykvT CDS" gene 1329701..1330327 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /label="ykvT gene" downshifts 1330258 /Source="Nicolas_upshifts" /id="D767" /incds=1 /nref=1 /ntot=17 /MaxReadThrough="0.932830000000001" /MaxDrop="1.92264" /score="9.80914166" /energy="-11.9" /TU="NA" /idTUdmin="U1125" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1330384..1330389 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1330396 /Source="Nicolas_upshifts" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1330405..1330423 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1330445..1331782 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15686839, 15849754, 16850406, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15686839, 15849754, 16850406, 19648239; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore membrane protein involved in germination" /protein_id="NP_389266.1" /db_xref="EnsemblGenomes-Gn:BSU13830" /db_xref="EnsemblGenomes-Tr:CAB13256" /db_xref="GOA:O31686" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="SubtiList:BG13323" /db_xref="UniProtKB/Swiss-Prot:O31686" /translation="MNRFVKGIILLSIAAFFAECLEFVVNMILARELGEHGMGLYMSI LPTIFLIIVIASLELPISISKFIAESNPKLHESMLRHAFRMTAIFTAFSTAAASIALP FIPVFDTYHPFIKGIVIGLIPVVAFTSIARGYFMGVQKMGKIAIANVLKKIIQLLCLF LFFQWYSFELDMAVLISLFVLVVSDVVVLVYLYSQFIMARRALSGQQHIHLRGKDVRK RLLAVSIPTTGLRIFHAVVNAIEPFLVKGALLAAGVAGTAAIDQYGMLAGVAVTIGSF PAFIAHSLMVVMIPSISEAYALSQYDIVLKRLKQSIFITLGYGIPAVWVMFQFAGPLT HLFFHSPEAQYYLQLLWPYFLFHLFVMPLQACLIGMGFVKEAFYHNVWSHIVALSMMY VLGSMENLQMLGIILGMNTGMILLTSLHYATICKALKVSVFLTGGTRTPRIEG*" /label="ykvU CDS" gene 1330445..1331782 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /label="ykvU gene" CDS 1331833..1332330 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15292147, 15322369, 15342593, 19144642, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292147, 15322369, 15342593, 19144642, 28383125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific thiol-disulfide oxidoreductase (SpoVD maturation)" /protein_id="NP_389267.1" /db_xref="EnsemblGenomes-Gn:BSU13840" /db_xref="EnsemblGenomes-Tr:CAB13257" /db_xref="GOA:O31687" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:3ERW" /db_xref="SubtiList:BG13324" /db_xref="UniProtKB/Swiss-Prot:O31687" /translation="MLTKRLLTIYIMLLGLIAWFPGAAQAEEKQPAVPAVFLMKTIEG EDISIPNKGQKTILHFWTSWCPPCKKELPQFQSFYDAHPSDSVKLVTVNLVNSEQNQQ VVEDFIKANKLTFPIVLDSKGELMKEYHIITIPTSFLLNEKGEIEKTKIGPMTAEQLK EWTEE*" /label="stoA CDS" gene 1331833..1332330 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /label="stoA gene" promotor_-35 1332179..1332185 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1332194 /Source="Nicolas_upshifts" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1332200..1332218 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1332304 /Source="Nicolas_upshifts" /id="D768" /incds=0 /nref=36 /ntot=164 /MaxReadThrough="1.89069" /MaxDrop="4.34947" /score="14.1388498" /energy="-11.3" /TU="NA" /idTUdmin="U1127" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1332425..1332431 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1332442..1332461 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1332454 /Source="Nicolas_upshifts" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1332458..1332565 /Source="Nicolas_S_feature" /locus_tag="new_1451263_1451370" /HighExp="LBGstat, C90, Lbstat, BC, Cold, T0.30H, Etha, Lbtran, LBGtran, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S502" CDS 1332566..1334479 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029044, 12180919, 15802251, 21813502, 26261021, 26566138" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12180919, 15802251, 21813502, 26261021, 26566138; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Fe(II) efflux transporter possibly involved in copper(II) uptake" /protein_id="NP_389268.1" /db_xref="EnsemblGenomes-Gn:BSU13850" /db_xref="EnsemblGenomes-Tr:CAB13258" /db_xref="GOA:O31688" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13325" /db_xref="UniProtKB/Swiss-Prot:O31688" /translation="MNEQVIVQRDPHEPLKTDKREKNWAQHAELIAALVSGALILAGW LLSGYQVLSIILFLLAFVIGGFAKAKEGIEETLESKTLNVELLMIFAAIGSALIGYWA EGAILIFIFSLSGALETYTMNKSSRDLTSLMQLEPEEATLMVNGETKRVPVSDLQAGD MIVIKPGERVAADGIIESGSTSLDESALTGESMPVEKNTGDTVFTGTVNRNGSLTVRV TKANEDSLFRKIIKLVESAQNSVSPAQAFIERFENAYVKGVLIAVALLLFVPHFALGW SWSETFYRAMVFMVVASPCALVASIMPAALSLISNGARNGMLVKGSVFLEQLGSVQMI AFDKTGTVTKGQPAVETIRIAEGFSEAEVLEAVYAIETQSSHPLAQAITAYAESRGVN QSGYISIEETSGFGVMAEVSGAKWKVGKAGFIGEEMAAQFMKQTASDVIQSGHTIVFV KKDDQIAGCIALKDQIRPEAKEVMEELNRLGIKTAMLTGDHEDTAQAIAKEAGMTTVV AECLPDQKVNEIKRLKEEFGTIAMVGDGINDAPALKAADVGIAMGGGTDVALETADMV LMKNDLKKLVNMCRLSRKMNRIIKQNIVFSLAVICLLICANFLQAMELPFGVIGHEGS TILVILNGLRLLK*" /label="pfeT CDS" gene 1332566..1334479 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /label="pfeT gene" promotor_-10 complement(1332715..1332734) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1332732) /Source="Nicolas_upshifts" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1332747..1332756) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1332883..1332902) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1332908) /Source="Nicolas_upshifts" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1332916..1332922) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1334460 /Source="Nicolas_upshifts" /id="D769" /incds=0 /nref=62 /ntot=148 /MaxReadThrough="2.05978" /MaxDrop="6.90668" /score="30.2111295" /energy="-18" /TU="NA" /idTUdmin="U1129" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1334536) /Source="Nicolas_upshifts" /id="D770" /incds=0 /nref=74 /ntot=208 /MaxReadThrough="0.83751" /MaxDrop="4.23141" /score="34.2342147" /energy="-18" /TU="NA" /idTUdmin="U1132" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1334747..1334766) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1334756) /Source="Nicolas_upshifts" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1334780..1334787) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1334831..1334850 /Source="Nicolas_upshift_promotors" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1334841 /Source="Nicolas_upshifts" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="upshifts" CDS 1334886..1335977 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7770058, 23144141" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7770058, 23144141; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Xaa-Pro Xaa-Pro-Xaa di-tri-peptidase used in osmoprotection" /protein_id="NP_389269.1" /db_xref="EnsemblGenomes-Gn:BSU13860" /db_xref="EnsemblGenomes-Tr:CAB13259" /db_xref="GOA:O31689" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG13326" /db_xref="UniProtKB/Swiss-Prot:O31689" /translation="MNRIQRVSSWLKEAGHTAAFIHTKENVFYLTGFYTEPHERLMGL FIFQEEEPFFVCPGMEAGQARNAGWNHEIIGYADHENPWELIEKALKKRNISIHMLAV EKDSISLSRAEQLKHATGGAQFVSAEETLNQFRLIKDDNEIRLLKEAAKLADYGVEVG TAALREGISEVEVLAQIEYELKKKGIQGMSFSTMVLFGEKSGQPHGNPGTATLKKGDF VLFDLGVILDGYCSDITRTFAYKTINPKQEAIYETVLQAEKAAIEASKPGVRIGDLDL TARGIIEKAGYGDYFPHRLGHGLGISVHEYPSMSQANDTLLQEGMVYTIEPGIYVPEI GGVRIEDDVHVTKDGAVALTQYPKDLIIL*" /label="papB CDS" gene 1334886..1335977 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /label="papB gene" downshifts 1335626 /Source="Nicolas_upshifts" /id="D771" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.10599" /MaxDrop="5.06339" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts 1335956 /Source="Nicolas_upshifts" /id="D772" /incds=0 /nref=2 /ntot=52 /MaxReadThrough="5.66039" /MaxDrop="2.56719" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" S_feature complement(1335990..1336208) /Source="Nicolas_S_feature" /locus_tag="new_1454795_1455013_c" /HighExp="B60, B36, C30, G135, LBGstat, S8, Lbstat, C90, Etha, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.92748200000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S503" S_feature 1336001..1336258 /Source="Nicolas_S_feature" /locus_tag="new_1454806_1455063" /HighExp="dia15, dia5, Etha, M0t90, M40t90, Lbstat, H2O2, G150, Mt0, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S504" promotor_-10 complement(1336195..1336214) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1336208) /Source="Nicolas_upshifts" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1336230..1336237) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1336259..1337224 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LacI family)" /protein_id="NP_389270.1" /db_xref="EnsemblGenomes-Gn:BSU13870" /db_xref="EnsemblGenomes-Tr:CAB13260" /db_xref="GOA:O31690" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13327" /db_xref="UniProtKB/Swiss-Prot:O31690" /translation="MANIKDIAEKAGVSVTTVSRVINNHPYVSEDKRKRVFEAMESLE YTRNIHAVHLSKGFSNMIGVVLPTVNLPYFAELIAGIADAAAESGVHLSLFQTNYEVQ KEIFALSQLKQRQVDGLIFCSKALADEKLMEWEGPILLCQNSDNARFPTISIPHQEAF RNGLDYLIAKGHKKIAICLARKKGMNSHFRIKAYKEALEEIGEAFREDWVIEKAITIN DGKALFHKWNTWKEKPTAIFVANDQVSAGLFLEAKNQRVSVPDELAILSVDNHEISQA LGITTIDIQTREMGKQAFAILEKRIQGQPIERKVLDYRLIERSTV*" /label="ykvZ CDS" gene 1336259..1337224 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /label="ykvZ gene" promotor_-35 1337242..1337249 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-35" promotor_-10 1337264..1337283 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-10" upshifts 1337276 /Source="Nicolas_upshifts" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="upshifts" CDS 1337287..1338153 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10974121, 14527945, 15155854, 17074746, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974121, 14527945, 15155854, 17074746, 22750856; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_389271.2" /db_xref="EnsemblGenomes-Gn:BSU13880" /db_xref="EnsemblGenomes-Tr:CAB13261" /db_xref="GOA:O31691" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:3GWH" /db_xref="PDB:3RIO" /db_xref="PDB:3UFE" /db_xref="SubtiList:BG12593" /db_xref="UniProtKB/Swiss-Prot:O31691" /translation="MTKELRIVNGSFTVKKVLNNNVLIASHHKYSEVVLIGKGIGFGK KQDDVIEDKGYDKMFILKDEKEQKQFKKLLDYVDEKLVDISNDVIYHISNRTNHSLNE HIHIALTDHIAFAIKRQQQGFDMKNPFLMETQSLYPEEYQIAKEVIDMINEKAGLCLP EGEIGFIALHIHSALTNRPLSEVNQHSQLMAQLVEVIEDSFQMKVNKESVNYLRLIRH IRFTIERIKKEEPTKEPEKLMLLLKNEYPLCYNTAWKLIKILQQTLKKPVHEAEAVYL TLHLYRLTNKIS*" /label="glcT CDS" gene 1337287..1338153 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /label="glcT gene" promotor_-35 1338008..1338012 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1338029..1338048 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1338037 /Source="Nicolas_upshifts" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" downshifts 1338155 /Source="Nicolas_upshifts" /id="D773" /incds=0 /nref=1 /ntot=30 /MaxReadThrough="9.01653" /MaxDrop="3.09921" /score="-5.18621526" /energy="-6.2" /TU="U1133,U1135,U1136" /idTUdmin="U1135" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_RNA 1338200..1338351 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /product="riboswitch regulating ptsGHI expression via GlcTbinding" /experiment="publication(s) with functional evidences, PMID:15155854, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15155854, 22750856; Product type n: RNA" /label="gswA RNA" S_feature 1338200..1338351 /Source="Nicolas_S_feature" /locus_tag="new_1457005_1457156" /HighExp="LBGexp, G150, C30, G135, G180, MG 90, dia0, Lbexp, dia15, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.988, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S505" gene 1338200..1338351 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /label="gswA gene" promotor_-35 1338329..1338335 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1338349..1338360 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1338353 /Source="Nicolas_upshifts" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="upshifts" CDS 1338382..1340481 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /EC_number="2.7.1.199" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucose-specificenzyme IICBA component" /protein_id="NP_389272.1" /db_xref="EnsemblGenomes-Gn:BSU13890" /db_xref="EnsemblGenomes-Tr:CAB13262" /db_xref="GOA:P20166" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="PDB:1AX3" /db_xref="PDB:1GPR" /db_xref="SubtiList:BG10198" /db_xref="UniProtKB/Swiss-Prot:P20166" /translation="MFKALFGVLQKIGRALMLPVAILPAAGILLAIGNAMQNKDMIQV LHFLSNDNVQLVAGVMESAGQIVFDNLPLLFAVGVAIGLANGDGVAGIAAIIGYLVMN VSMSAVLLANGTIPSDSVERAKFFTENHPAYVNMLGIPTLATGVFGGIIVGVLAALLF NRFYTIELPQYLGFFAGKRFVPIVTSISALILGLIMLVIWPPIQHGLNAFSTGLVEAN PTLAAFIFGVIERSLIPFGLHHIFYSPFWYEFFSYKSAAGEIIRGDQRIFMAQIKDGV QLTAGTFMTGKYPFMMFGLPAAALAIYHEAKPQNKKLVAGIMGSAALTSFLTGITEPL EFSFLFVAPVLFAIHCLFAGLSFMVMQLLNVKIGMTFSGGLIDYFLFGILPNRTAWWL VIPVGLGLAVIYYFGFRFAIRKFNLKTPGREDAAEETAAPGKTGEAGDLPYEILQAMG DQENIKHLDACITRLRVTVNDQKKVDKDRLKQLGASGVLEVGNNIQAIFGPRSDGLKT QMQDIIAGRKPRPEPKTSAQEEVGQQVEEVIAEPLQNEIGEEVFVSPITGEIHPITDV PDQVFSGKMMGDGFAILPSEGIVVSPVRGKILNVFPTKHAIGLQSDGGREILIHFGID TVSLKGEGFTSFVSEGDRVEPGQKLLEVDLDAVKPNVPSLMTPIVFTNLAEGETVSIK ASGSVNREQEDIVKIEK*" /label="ptsG CDS" gene 1338382..1340481 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /label="ptsG gene" promotor_-35 1340499..1340503 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1340519..1340538 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1340530 /Source="Nicolas_upshifts" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1340579..1340845 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="histidine-containing phosphocarrier protein of the phosphotransferase system (PTS) (HPr protein)" /protein_id="NP_389273.1" /db_xref="EnsemblGenomes-Gn:BSU13900" /db_xref="EnsemblGenomes-Tr:CAB13263" /db_xref="GOA:P08877" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR001020" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1JEM" /db_xref="PDB:1KKL" /db_xref="PDB:1KKM" /db_xref="PDB:1SPH" /db_xref="PDB:2FEP" /db_xref="PDB:2HID" /db_xref="PDB:2HPR" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10200" /db_xref="UniProtKB/Swiss-Prot:P08877" /translation="MAQKTFKVTADSGIHARPATVLVQTASKYDADVNLEYNGKTVNL KSIMGVMSLGIAKGAEITISASGADENDALNALEETMKSEGLGE*" /label="ptsH CDS" gene 1340579..1340845 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /label="ptsH gene" CDS 1340845..1342557 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /EC_number="2.7.3.9" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106335, 11902727, 15155854, 15670601, 25355936, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106335, 11902727, 15155854, 15670601, 25355936, 26159071; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) enzyme I" /protein_id="NP_389274.2" /db_xref="EnsemblGenomes-Gn:BSU13910" /db_xref="EnsemblGenomes-Tr:CAB13264" /db_xref="GOA:P08838" /db_xref="InterPro:IPR000121" /db_xref="InterPro:IPR006318" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR008731" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018274" /db_xref="InterPro:IPR023151" /db_xref="InterPro:IPR024692" /db_xref="InterPro:IPR036618" /db_xref="SubtiList:BG10201" /db_xref="UniProtKB/Swiss-Prot:P08838" /translation="MQELKGIGASAGIAIAKAYRLEEPDLTVEKKNISDSEAEVSRFD EAIARSKEELEKIKEHALKELGQDKADIFSAHLLVLSDPELLNPVKEKISTDSVNAEF ALKETSSMFVTMFESMDNEYMKERAADIRDVTKRVTGHLLGVEIPNPSMISEEVIIVA EDLTPSDTAQLNREFVKGFTTDIGGRTSHSAIMARSLEIPAVVGTKAATGTIQNGVTV IVDGINGDVIIDPSAETVKEYEEKHNAYLAQKAEWAKLVNEPTVSKDGHHVELAANIG TPDDVKGVLENGGEAVGLYRTEFLYMGRDQLPTEDEQFDAYKTVLERMEGKSVVVRTL DIGGDKELPYLQLPKEMNPFLGYRAIRLCLEEQEIFRTQLRALLRASTYGNLKIMFPM IATVNEFKEAKAILLEEKEKLVKAGQAVSDDIEVGMMVEIPSTAVIADQFAKEVDFFS IGTNDLIQYTMAADRMNERVSYLYQPYNPAILRLITLVIEAAHKEGKWVGMCGEMAGD EIAIPILLGLGLDEFSMSATSILPARTQISKLSKQEAESFKEKILSMSTTEEVVAFVK ETFK*" /label="ptsI CDS" gene 1340845..1342557 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /label="ptsI gene" downshifts 1342544 /Source="Nicolas_upshifts" /id="D774" /incds=0 /nref=116 /ntot=277 /MaxReadThrough="5.0255" /MaxDrop="5.64321" /score="21.2608168" /energy="-12.3" /TU="U1136,U1138" /idTUdmin="U1133" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-35 1342597..1342603 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1342618..1342629 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1342621 /Source="Nicolas_upshifts" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1342648..1342887 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9009064, 9323362, 10629212" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9009064, 9323362, 10629212; Product type r: regulator" /codon_start=1 /transl_table=11 /product="TRAP-like transcriptional negative regulator of spore photoproduct lyase" /protein_id="NP_389275.1" /db_xref="EnsemblGenomes-Gn:BSU13920" /db_xref="EnsemblGenomes-Tr:CAB13265" /db_xref="GOA:P37955" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG10202" /db_xref="UniProtKB/Swiss-Prot:P37955" /translation="MSNQFNAGDTVYVIYRNPHAANVAHIKEAEIVHHPYHEGELSLF IYETYHPFAEDDAVFASYEEAKSLYKELFDIDPYE*" /label="splA CDS" gene 1342648..1342887 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /label="splA gene" S_feature complement(1342668..1344007) /Source="Nicolas_S_feature" /locus_tag="new_1461473_1462812_c" /HighExp="T4.0H, T3.30H, T3.0H, S3, S1, T2.0H, T2.30H, S2, T5.0H, S4" /AntisenseName="splB" /AntisenseCor="-0.193138593783996" /AntisenseRegPval="-2.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S506" CDS 1342965..1343993 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /EC_number="4.1.99.14" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore photoproduct (thymine dimer) lyase" /protein_id="NP_389276.1" /db_xref="EnsemblGenomes-Gn:BSU13930" /db_xref="EnsemblGenomes-Tr:CAB13266" /db_xref="GOA:P37956" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023897" /db_xref="InterPro:IPR034560" /db_xref="SubtiList:BG10203" /db_xref="UniProtKB/Swiss-Prot:P37956" /translation="MQNPFVPQLVYIEPRALEYPLGQELQDKFENMGIEIRETTSHNQ VRNIPGKNHLQQYRNAKSTLVIGVRKTLKFDSSKPSAEYAIPFATGCMGHCHYCYLQT TMGSKPYIRTYVNVEEILDQADKYMKERAPEFTRFEASCTSDIVGIDHLTHTLKRAIE HFGQSDLGKLRFVTKFHHVDHLLDAKHNGKTRFRFSINADYVIKNFEPGTSPLDKRIE AAVKVAKAGYPLGFIVAPIYIHEGWEEGYRHLFEKLDAALPQDVRHDITFELIQHRFT KPAKRVIEKNYPKTKLELDEEKRRYKWGRYGIGKYIYQKDEEHALREALESYIDTFFP NAKIEYFT*" /label="splB CDS" gene 1342965..1343993 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /label="splB gene" downshifts 1343963 /Source="Nicolas_upshifts" /id="D775" /incds=0 /nref=5 /ntot=113 /MaxReadThrough="0.352" /MaxDrop="3.95383" /score="15.9223136" /energy="-13.2" /TU="NA" /idTUdmin="U1136" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1344008..1344688) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase / amidohydrolase" /protein_id="NP_389277.2" /db_xref="EnsemblGenomes-Gn:BSU13940" /db_xref="EnsemblGenomes-Tr:CAB13267" /db_xref="GOA:Q796K9" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12252" /db_xref="UniProtKB/Swiss-Prot:Q796K9" /translation="MIILKQMYVHDGRKFEALTIRNYTETDIERLISLQEECFPPPFP QELLWSEDQLASHIKTFPEGALCALINGRIIGSMTALIVQFEPDSPDHTWAQATDNGS IKNHEPHGNTLYVVDISVSPHYRKLGIGKWLMNTMYELTVDKRLERLLGGGRIPLYYK YAHEISAVQYVEDVMEGRKNDPVLSFLLRCGRSPIRVVSNYLEDKESLNYGVLMEWKN VFYKKASC*" /label="ykwB CDS" gene complement(1344008..1344688) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /label="ykwB gene" promotor_-10 complement(1344698..1344717) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1344721) /Source="Nicolas_upshifts" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1344732..1344739) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1344773..1344780 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-35" promotor_-10 1344794..1344812 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-10" upshifts 1344800 /Source="Nicolas_upshifts" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="upshifts" CDS 1344823..1346790 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9721285, 11722727, 12603740, 15317802, 23038252, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9721285, 11722727, 12603740, 15317802, 23038252, 27899502; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_389278.2" /db_xref="EnsemblGenomes-Gn:BSU13950" /db_xref="EnsemblGenomes-Tr:CAB13268" /db_xref="GOA:P54576" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG11533" /db_xref="UniProtKB/Swiss-Prot:P54576" /translation="MFKKLHMKIAVFVSIMLIITVVLLMLSSYLTLKPMITEDGKNTT QNVTQSLEQNIELQLKSYAISLSRLANGELTHTFVTKPSKEASRLFHDDIKQIKDNDD YVAMAYIGTAKKEMFTYPKADFAEDYDPTSRPWYKLAAETPDQVVWTEPYKDVVTGDM IVTASKAILDRQKVIGVASYDLKLSAIQSMVNKQKVPYKGFAFLADASGNLLAHPSNQ GKNISKDQTLQTIASEKKGIQDVNGKMVVYQTIGETGWKVGTQFDTDQLMWISDKMNR ANLWISLIALIITIILSYFLAKTITGPIQQLIVKTKAVSAGDLTVRAESKSKDEVGIL TRDFNLMVENMKEMVEQVRLSSGKVSDTSEQLTAVAAETNETSGQIAKAIEEVAAGAS EQASEVETINEKSESLSTKIRQIAEEAGGIKERSKSSEDASYKGLDALGQLLMKSNEA NMETKKVETMLLDLENQTKNIEEVVTAISNISDQTNLLALNASIEAARAGESGRGFAV VADEVRKLAEQSALSTKHISETVKLIQLETKEASHAMVEASRMNDEQNSAIHETGEVL NTITAEMQSLVQGIDHIYAEIQRMSEEQLAISEAIQSISAISQESAAAAEEVNASTDE QLVTLDKVKHSTETLKHASQELMNTIAKFTL*" /label="mcpC CDS" gene 1344823..1346790 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /label="mcpC gene" misc_feature complement(1345263..1345278) /Source="Nicolas_upshift_promotors" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1345275) /Source="Nicolas_upshifts" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1346761 /Source="Nicolas_upshifts" /id="D776" /incds=0 /nref=134 /ntot=209 /MaxReadThrough="3.05506" /MaxDrop="5.75836" /score="24.6367658" /energy="-12.1" /TU="U1141" /idTUdmin="U1141" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1346834..1346836 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1346852..1346871 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1346862 /Source="Nicolas_upshifts" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1346904) /Source="Nicolas_upshifts" /id="D777" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="2.29647" /MaxDrop="4.49503" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=946 /isTUend="FALSE" /label="downshifts" CDS 1346928..1347794 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /EC_number="1.1.1.60" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20941576, 24390483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20941576, 24390483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacid dehydrogenase (acts on 3-hydroxypropionate with NADP)" /protein_id="NP_389279.1" /db_xref="EnsemblGenomes-Gn:BSU13960" /db_xref="EnsemblGenomes-Tr:CAB13269" /db_xref="GOA:O34948" /db_xref="InterPro:IPR002204" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13328" /db_xref="UniProtKB/Swiss-Prot:O34948" /translation="MKKTIGFIGLGVMGKSMASHILNDGHPVLVYTRTKEKAESILQK GAIWKDTVKDLSKEADVIITMVGYPSDVEEVYFGSNGIIENAKEGAYLIDMTTSKPSL AKKIAEAAKEKALFALDAPVSGGDIGAQNGTLAIMVGGEKEAFEACMPIFSLMGENIQ YQGPAGSGQHTKMCNQIAIAAGMIGVAEAMAYAQKSGLEPENVLKSITTGAAGSWSLS NLAPRMLQGNFEPGFYVKHFIKDMGIALEEAELMGEEMPGLSLAKSLYDKLAAQGEEN SGTQSIYKLWVK*" /label="ohaC CDS" gene 1346928..1347794 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /label="ohaC gene" downshifts 1347774 /Source="Nicolas_upshifts" /id="D778" /incds=0 /nref=239 /ntot=266 /MaxReadThrough="2.14032" /MaxDrop="8.18847" /score="41.1703019" /energy="-14.5" /TU="NA" /idTUdmin="U1143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1347833..1348606) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389280.2" /db_xref="EnsemblGenomes-Gn:BSU13970" /db_xref="EnsemblGenomes-Tr:CAB13270" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR014258" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13329" /db_xref="UniProtKB/Swiss-Prot:O31398" /translation="MKKAFILSAAAAVGLFTFGGVQQASAKELSCQPVVTVKTGNTVQ NMSLNDAVKKLHINTNIKTLNAANEKEMKQLLQKHAKQSNVKVQDVQKTETAKPAQKT TEKAAADQNTASKAPATAEKTNTTTSAPSSVSAYEKKVVELTNAERQKQGLKPLQIDE TLSKSARAKSQDMKDKNYFDHQSPTYGSPFDMMKSFGISYKTAGENIAKGQKTPEEVV KAWMNSEGHRKNILNPNFTHIGVGYVESGSIWTQQFIGK*" /label="ykwD CDS" gene complement(1347833..1348606) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /label="ykwD gene" downshifts complement(1347850) /Source="Nicolas_upshifts" /id="D779" /incds=0 /nref=31 /ntot=168 /MaxReadThrough="1.32532" /MaxDrop="5.28625" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1348638..1348657) /Source="Nicolas_upshift_promotors" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1348648) /Source="Nicolas_upshifts" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1348881..1348900 /Source="Nicolas_upshift_promotors" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1348894 /Source="Nicolas_upshifts" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1348896..1348999 /Source="Nicolas_S_feature" /locus_tag="new_1467701_1467804" /HighExp="T4.0H, T3.30H, T3.0H, Etha, T5.0H, T2.30H, LoTm, B60, T2.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S507" CDS 1348943..1351057 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12896990, 23199363" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12896990, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding enzyme for formation of rod-shaped peptidoglycan cell wall" /protein_id="NP_389281.2" /db_xref="EnsemblGenomes-Gn:BSU13980" /db_xref="EnsemblGenomes-Tr:CAB13271" /db_xref="GOA:Q796K8" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13286" /db_xref="UniProtKB/Swiss-Prot:Q796K8" /translation="MTEIGREPKKKSKGNRAIRMNLFFLAVFVLFTALIFKLGVVQIV EGEQHEEDAEKSNAKTAYYPAPRGKMYDRNQKVAVDNQSVPEIVYVSTSSTKTEDKIK TAKRLASFIHIDTEFLKERDLRDYWIAAHPKKAAALLKESESNLKGDQAYKLQIERVP DQELKAIQQDDEEMETAAIYTRFSSGNAYEPQIVKAMNPNKSNSNGKNGALLDEKKNS SQRPKNDLTYDEISIVSEHLEELPGIDIVNDWTRKYPYDKTLYSVFGGVTTPDQGLLS DRKDFYLTRGYANNDRVGKSYLEYQYEEYLNSHKEKVEYVEDNKGNVVSQKTIDKGSR GYDLQLSFDMELQAKVEKIIEEEVRNSRARGNYMLDRAFAVMMDPNNGDILSMAGKKI DLKTNKIEDYAIGAFTTQYEMGSAVKGATVLAGYQDGIPHYKYYIDAPMLLGTNLIKK SYTNMGTINELTALQKSSNVYMFNVAMHIAGVTYKPHGSLPADQNDLLKMRNYYSQFG LGVKTGIDLPQESAGMQTTPKTVGGLILDLAIGQYDTYTPLQMAQYISVIANGGYRVQ PRIVTSIHKPGKKDQLGKAIEHRKPKVLNKINNSESDLKQVQTGMKLVTSSGTAKNTF TEDVSGKTGTAETFYYGTNRNWWGKKTYNLTFVGYYPSKKPKVAFSVVVPSVDDDDKI NKIIAKRAIHAYAELEKKHSKK*" /label="pbpH CDS" gene 1348943..1351057 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /label="pbpH gene" promotor_-10 complement(1350236..1350254) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1350248) /Source="Nicolas_upshifts" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1350270..1350275) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1351038 /Source="Nicolas_upshifts" /id="D780" /incds=0 /nref=139 /ntot=246 /MaxReadThrough="3.36066" /MaxDrop="5.01597" /score="-1.2500858" /energy="-12" /TU="U1145" /idTUdmin="U1145" /TUdmin="-1862" /isTUend="FALSE" /label="downshifts" promotor_-35 1351130..1351138 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1351150..1351168 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1351162 /Source="Nicolas_upshifts" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="upshifts" CDS 1351221..1353041 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific ATP-dependent protein histidine kinase" /protein_id="NP_389282.1" /db_xref="EnsemblGenomes-Gn:BSU13990" /db_xref="EnsemblGenomes-Tr:CAB13272" /db_xref="GOA:P16497" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013655" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:2VLG" /db_xref="SubtiList:BG10204" /db_xref="UniProtKB/Swiss-Prot:P16497" /translation="MEQDTQHVKPLQTKTDIHAVLASNGRIIYISANSKLHLGYLQGE MIGSFLKTFLHEEDQFLVESYFYNEHHLMPCTFRFIKKDHTIVWVEAAVEIVTTRAER TEREIILKMKVLEEETGHQSLNCEKHEIEPASPESTTYITDDYERLVENLPSPLCISV KGKIVYVNSAMLSMLGAKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQ TWKRLDGTPVHLEVKASPTVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNS IDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQ KTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGEAAVQVILRDISERKQTEELMLKSEK LSIAGQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFDIVFSELSRIELILSELL MLAKPQQNAVKEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQ VFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKE KGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK*" /label="kinA CDS" gene 1351221..1353041 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /label="kinA gene" CDS complement(1353052..1354233) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /EC_number="2.6.1.83" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 14523133, 14627808, 19948795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 14523133, 14627808, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-L,L-diaminopimelate aminotransferase" /protein_id="NP_389283.2" /db_xref="EnsemblGenomes-Gn:BSU14000" /db_xref="EnsemblGenomes-Tr:CAB13273" /db_xref="GOA:P16524" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10205" /db_xref="UniProtKB/Swiss-Prot:P16524" /translation="MEHLLNPKAREIEISGIRKFSNLVAQHEDVISLTIGQPDFFTPH HVKAAAKKAIDENVTSYTPNAGYLELRQAVQLYMKKKADFNYDAESEIIITTGASQAI DAAFRTILSPGDEVIMPGPIYPGYEPIINLCGAKPVIVDTTSHGFKLTARLIEDALTP NTKCVVLPYPSNPTGVTLSEEELKSIAALLKGRNVFVLSDEIYSELTYDRPHYSIATY LRDQTIVINGLSKSHSMTGWRIGFLFAPKDIAKHILKVHQYNVSCASSISQKAALEAV TNGFDDALIMREQYKKRLDYVYDRLVSMGLDVVKPSGAFYIFPSIKSFGMTSFDFSMA LLEDAGVALVPGSSFSTYGEGYVRLSFACSMDTLREGLDRLELFVLKKREAMQTINNG V*" /label="dapX CDS" gene complement(1353052..1354233) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /label="dapX gene" downshifts complement(1353086) /Source="Nicolas_upshifts" /id="D781" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="1.89632" /MaxDrop="6.70715" /score="-6.17975559" /energy="-4.7" /TU="NA" /idTUdmin="U1148" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1354261..1354280) /Source="Nicolas_upshift_promotors" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1354277) /Source="Nicolas_upshifts" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1354309..1354327) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1354321) /Source="Nicolas_upshifts" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1354323..1354391) /Source="Nicolas_S_feature" /locus_tag="new_1473128_1473196_c" /HighExp="M9-stat, Lbtran, Lbstat, T3.30H, T3.0H, T2.30H, M0t90, T4.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S508" promotor_-35 complement(1354342..1354347) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1354385..1354404) /Source="Nicolas_upshift_promotors" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1354391) /Source="Nicolas_upshifts" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1354435..1354596) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097722.1" /db_xref="EnsemblGenomes-Gn:BSU14009" /db_xref="EnsemblGenomes-Tr:CAX52613" /db_xref="UniProtKB/Swiss-Prot:C0H406" /translation="MGTLVIFKENEMTVLEDISEETYLNMKKESADLQEEHPPYLIWH EDLHFDYGY*" /label="ykzT CDS" gene complement(1354435..1354596) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /label="ykzT gene" promotor_-10 complement(1354619..1354638) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1354632) /Source="Nicolas_upshifts" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1354652..1354659) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1354733..1354740 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1354752 /Source="Nicolas_upshifts" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1354753..1354771 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1354800..1355711 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11553614, 12864845, 14731274, 14993307, 26844549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11553614, 12864845, 14731274, 14993307, 26844549; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling protein and response regulator for CheAactivity in response to attractants (chemotaxis)" /protein_id="NP_389284.1" /db_xref="EnsemblGenomes-Gn:BSU14010" /db_xref="EnsemblGenomes-Tr:CAB13274" /db_xref="GOA:P37599" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024181" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10823" /db_xref="UniProtKB/Swiss-Prot:P37599" /translation="MSLQQYEILLDSGTNELEIVKFGVGENAFGINVMKVREIIQPVE VTSVPHSHQHVEGMIKLRGEILPVISLFSFFGVEPEGSKDEKYIVTEFNKRKIVFHVG SVSQIHRVSWEAIEKPTSLNQGMERHLTGIIKLEDLMIFLPDYEKIIYDIESDSGVDT YNMHTEGFDERRTDKKLIIVEDSPLLMRLLQDELKEAGYNNIASFENGKEAYEYIMNL AENETDLSKQIDMIITDIEMPKMDGHRLTKLLKENPKSSDVPVMIFSSLITDDLRHRG EVVGADEQISKPEISDLIKKVDTYVIE*" /label="cheV CDS" gene 1354800..1355711 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /label="cheV gene" downshifts complement(1354805) /Source="Nicolas_upshifts" /id="D782" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="1.14523" /MaxDrop="3.62759" /score="-8.29055697" /energy="-7.7" /TU="NA" /idTUdmin="U1154" /TUdmin=968 /isTUend="FALSE" /label="downshifts" promotor_-35 1355254..1355262 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1355276..1355293 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1355279 /Source="Nicolas_upshifts" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1355696 /Source="Nicolas_upshifts" /id="D783" /incds=0 /nref=188 /ntot=251 /MaxReadThrough="4.61331" /MaxDrop="6.23797" /score="15.4598573" /energy="-13.1" /TU="U1152" /idTUdmin="U1153" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1355755..1356219) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of transcription factor ComK function via modulation of mRNA stability" /protein_id="NP_389285.1" /db_xref="EnsemblGenomes-Gn:BSU14020" /db_xref="EnsemblGenomes-Tr:CAB13275" /db_xref="InterPro:IPR025552" /db_xref="SubtiList:BG11202" /db_xref="UniProtKB/Swiss-Prot:P42430" /translation="MDDHAYTKDLQPTVENLSKAVYTVNRHAKTAPNPKYLYLLKKRA LQKLVKEGKGKKIGLHFSKNPRFSQQQSDVLISIGDYYFHMPPTKEDFEHLPHLGTLN QSYRNPKAQMSLTKAKHLLQEYVGMKEKPLVPNRQQPAYHKPVFKKLGESYF*" /label="kre CDS" gene complement(1355755..1356219) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /label="kre gene" downshifts complement(1355773) /Source="Nicolas_upshifts" /id="D784" /incds=0 /nref=212 /ntot=260 /MaxReadThrough="2.67186" /MaxDrop="6.66359" /score="16.1985615" /energy="-13.1" /TU="NA" /idTUdmin="U1154" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1356249..1356268) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1356259) /Source="Nicolas_upshifts" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1356283..1356290) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1356345..1357637) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389286.2" /db_xref="EnsemblGenomes-Gn:BSU14030" /db_xref="EnsemblGenomes-Tr:CAB13276" /db_xref="GOA:O31695" /db_xref="InterPro:IPR004751" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13287" /db_xref="UniProtKB/Swiss-Prot:O31695" /translation="MDIFKNRNFVRLFFAALASQMGTTVGNMAFAFFLLDRFSSQPSY TTLAELMYSLPTIFVFLIVGVVADRFDRKKVAENCDWIRAGLTVVLFFTLFTGNIPLV FCILFIRSAVTKFFFPAENSLVQAILPKEHYAKAAGLNQMLFSIFMVFGVGIGAFMYN TIGIEGAIILDFVSFIISGLLIRSCRIPKEARQPNGAFSWRKTSVKDSINDFREGILY ILKNKLLASLIFGFFIFGFVNGGFAVLPMFTMKYGLAPDRYEWHTSVFTIALGFGLLA GSVIGTLISKKVKPHFLMSIPIFIAGLLIFVLGYTNILWVYYAAAFALGMCIGPINIA IGGWMPKIVHPKLMGRVSGMQDPFMMFAQSLTLGLVALLFPKFVSNIDYLYYGMGVII LLVFIFYFIALPKYSAQAVEVNVQEAFQEQPKKKARSV*" /label="ykuC CDS" gene complement(1356345..1357637) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /label="ykuC gene" downshifts complement(1356367) /Source="Nicolas_upshifts" /id="D785" /incds=0 /nref=37 /ntot=206 /MaxReadThrough="4.24449" /MaxDrop="4.31411" /score="3.5676583" /energy="-14.2" /TU="U1155" /idTUdmin="U1156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1357661..1357680) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-10" upshifts complement(1357665) /Source="Nicolas_upshifts" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="upshifts" promotor_-35 complement(1357696..1357700) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-35" CDS complement(1357713..1358207) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11011148, 16287140, 23832002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16287140, 23832002; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="murein L,D-transpeptidase" /protein_id="NP_389287.1" /db_xref="EnsemblGenomes-Gn:BSU14040" /db_xref="EnsemblGenomes-Tr:CAB13277" /db_xref="GOA:O34816" /db_xref="InterPro:IPR005490" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:1Y7M" /db_xref="PDB:2MTZ" /db_xref="PDB:3ZQD" /db_xref="PDB:4A1I" /db_xref="PDB:4A1J" /db_xref="PDB:4A1K" /db_xref="PDB:4A52" /db_xref="SubtiList:BG13288" /db_xref="UniProtKB/Swiss-Prot:O34816" /translation="MLTYQVKQGDTLNSIAADFRISTAALLQANPSLQAGLTAGQSIV IPGLPDPYTIPYHIAVSIGAKTLTLSLNNRVMKTYPIAVGKILTQTPTGEFYIINRQR NPGGPFGAYWLSLSKQHYGIHGTNNPASIGKAVSKGCIRMHNKDVIELASIVPNGTRV TINR*" /label="ltdD CDS" gene complement(1357713..1358207) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /label="ltdD gene" promotor_-10 complement(1358223..1358242) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1358239) /Source="Nicolas_upshifts" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1358256..1358265) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1358264..1359124) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22767609, 24140208" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22767609, 24140208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported metallophosphoesterase (Mn2+ and Zn2+)" /protein_id="NP_389288.2" /db_xref="EnsemblGenomes-Gn:BSU14050" /db_xref="EnsemblGenomes-Tr:CAB13278" /db_xref="GOA:O34870" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR019546" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13289" /db_xref="UniProtKB/Swiss-Prot:O34870" /translation="MKKMSRRQFLKGMFGALAAGALTAGGGYGYARYLEPHMIETTEH TIKSSLIPHGFDGFKIVQFSDAHLSDYFTLEDLKTVILTINESKPDLIVFTGDIIDNP DTYQHHQAVIPLLRKLNAPFGKLCIYGNHDHGGYGTAVYKSLMTAGGFTVYRNGYQTL SLADGSKIEIASLDDLMLGNPDYEGTLSRLSDRLFSILLVHEPDAALKTTDYPVNLQL SGHTHGGQIQLPFYGPIITPPYGKVYTEGMYQTGSTHIYVNRGLGMTRLPLRFLAKPE ITVFTLKSTN*" /label="ppeE CDS" gene complement(1358264..1359124) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /label="ppeE gene" misc_feature complement(1359145..1359164) /Source="Nicolas_upshift_promotors" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1359158) /Source="Nicolas_upshifts" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="upshifts" promotor_-35 1359195..1359202 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-35" promotor_-10 1359218..1359237 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-10" upshifts 1359231 /Source="Nicolas_upshifts" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="upshifts" CDS 1359267..1360031 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /EC_number="1.3.1.34" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2,4-dienoyl-CoA reductase" /protein_id="NP_389289.1" /db_xref="EnsemblGenomes-Gn:BSU14060" /db_xref="EnsemblGenomes-Tr:CAB13279" /db_xref="GOA:O34717" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13290" /db_xref="UniProtKB/Swiss-Prot:O34717" /translation="MEKKAVIITGGSSGMGKAMAKKQAELGWHVMVTGRNHEALEETK KEIQTFEGQVACFQMDVRSDSAASDMIKEAVKAFGRLDALINNAAGNFICPAEKLTPN GWKAVIEIVLNGTFFCSQAAARHWIDQKQQGVILNMAATYAWGAGAGVVHSAAAKAGV LSLTRTLAVEWGSKYGIRTNAIAPGPIERTGGAEKLFESEKAMARTMNSVPLGRLGTP EEIAALAAFLLSDEASYINGDCITMDGGQWLNPYPF*" /label="fadH CDS" gene 1359267..1360031 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /label="fadH gene" S_feature 1360032..1360180 /Source="Nicolas_S_feature" /locus_tag="new_1478837_1478985" /HighExp="T0.30H, T1.0H, B60, Sw, BC, LoTm, M9-stat, S8, S7, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S509" misc_feature 1360161..1360179 /Source="Nicolas_upshift_promotors" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1360182..1360331 /Source="Nicolas_S_feature" /locus_tag="new_1478987_1479136" /HighExp="T0.30H, M40t90, T1.0H, B60, BC, Sw, LPh, LoTm, M9-stat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0, 0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S510" upshifts 1360182 /Source="Nicolas_upshifts" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1360229) /Source="Nicolas_upshifts" /id="D786" /incds=0 /nref=3 /ntot=49 /MaxReadThrough="1.82681" /MaxDrop="3.39884" /score="-0.170855674" /energy="-4.8" /TU="NA" /idTUdmin="U1157" /TUdmin="-2542" /isTUend="FALSE" /label="downshifts" CDS 1360332..1362062 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall-binding protein" /protein_id="YP_003097723.1" /db_xref="EnsemblGenomes-Gn:BSU14071" /db_xref="EnsemblGenomes-Tr:CAX52614" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="UniProtKB/Swiss-Prot:O34320" /translation="MDEMVLLTQEWLNETYKGKSGYNSIEENGKTGWKTMYALTRALQ LELGITQTSDSFGPTTLRKLKELGPISTSTNSKKNIVKIIQGALYCKGYGPGGLTGTF GQGTKEAIAEMQLHMGLSKTDGVVTPKVFKALLNMDSYILLNGASEKVRSIQQWLNNK YYNRENFYFMPCDGLYSRDTQKSLVYAIQYEEGLSDSIANGNFGPTTQRLIPVLRIGE TDEKNSFIHLFQAALIFNGYNVPFDGVYSESVRSKVKAFQSFAKLQQSGTADFQTWAS LLVSTGDPNRKGVACDSITQITSDRAESLKRAGYKIVGRYLTNAPGSTLNKKIQPGEL ETILKSGLNVFPIYQTYGGATNYFNKEQGKKDAFAAYKAAKEYGFKNNTVIYFAVDYD AYGNDLNNNIIPHFEGINEIMNGFLGSTYKIGIYAPRNVCTIVSKKGLAFASFVSGMS TGFSGNLGYPLPYNWAFDQISTITVGNGSGMIEIDNDICSGLDNGVNTINIVPSENKK FFDQIDVLYETAEKYAQMQSDLNNGVKKTQLANELVAQYLRKDDYKGWKWVPTAGQID PIYREWAVKR*" /label="ykuG CDS" gene 1360332..1362062 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /label="ykuG gene" CDS 1362128..1362646 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097724.1" /db_xref="EnsemblGenomes-Gn:BSU14072" /db_xref="EnsemblGenomes-Tr:CAX52615" /db_xref="UniProtKB/Swiss-Prot:C0H408" /translation="MATYNAIIYSGGYSQTLRDFAGWTGDLLTTIQDMKLHAQEFNSP YDAAMKIIGNMYQFSLDDLFSDVDAINLANKTSVGANAQPLNIAIRDYYSNNDCMNRF TQFVNNRFDGSLDKIFSEAEYYLNTNLDPVVVPIRLAFKRAFDVEDYSEEIGKITAQA FRDVIEKKMISE*" /label="ykzU CDS" gene 1362128..1362646 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /label="ykzU gene" downshifts 1362644 /Source="Nicolas_upshifts" /id="D787" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.57306" /MaxDrop="3.8585" /score="8.20824413" /energy="-13" /TU="U1158,U1159" /idTUdmin="U1158" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 1362689..1362694 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1362707..1362726 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1362710 /Source="Nicolas_upshifts" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="upshifts" CDS 1362742..1363290 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389291.1" /db_xref="EnsemblGenomes-Gn:BSU14080" /db_xref="EnsemblGenomes-Tr:CAB13281" /db_xref="GOA:O31696" /db_xref="SubtiList:BG13292" /db_xref="UniProtKB/Swiss-Prot:O31696" /translation="MKKLLKKLVVLFLSSLVIIFNVWYFIICAFSPEYYQNTNLTSNE IIRFEKLYHIDFPDETKFIKAREYLAGPGGDTSAVLYVSLPTKRVEKVLSDYTYMKIN YTDNVGSMYGVDVSKSVAGLTTLTFGTYDKKGTFYNMKHDDDWMYKGTDWNLYFWTAA SYNAVIFVFVLVIVKQMNKILN*" /label="ykuH CDS" gene 1362742..1363290 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /label="ykuH gene" S_feature 1363291..1363442 /Source="Nicolas_S_feature" /locus_tag="new_1482096_1482247" /HighExp="HiOs, LPhT, Salt, T0.0H, HiTm, T-0.40H, Fru, T-1.10H, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S511" CDS 1363443..1364666 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19244251, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative cyclic-di-GMP receptor (no phosphodiesterase activity)" /protein_id="NP_389292.1" /db_xref="EnsemblGenomes-Gn:BSU14090" /db_xref="EnsemblGenomes-Tr:CAB13282" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR018842" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035919" /db_xref="PDB:2BAS" /db_xref="PDB:2W27" /db_xref="SubtiList:BG13293" /db_xref="UniProtKB/Swiss-Prot:O35014" /translation="MLDPLDILTNIDDVLPYYQAIFSAEEQKVVGYEVLGRILADSEI QSLGPFFLDAGIPEEYKLEVDNRIIRQALDRFLEADSDLLIFMNQDANLLMLDHGESF LELLKEYEAKGIELHRFVLEITEHNFEGDIEQLYHMLAYYRTYGIKIAVDNIGKESSN LDRIALLSPDLLKIDLQALKVSQPSPSYEHVLYSISLLARKIGAALLYEDIEANFQLQ YAWRNGGRYFQGYYLVSPSETFLERDVLKQRLKTEFHQFITHEKKKLETVYEHSEQFY KRVHQAVTSLRKNNLSSDDDFIKKLAEELTDCSFRIYMCDEEGDQLTGNVFKQDGEWI YQPEYAEKNWSWRPYFLENIMRMRNLRKGFFSDLYSDLETGEMIRTFSYPMDDQMYLF IDLPYSYLYEQDGLI*" /label="ykuI CDS" gene 1363443..1364666 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /label="ykuI gene" promotor_-10 complement(1364629..1364647) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1364639) /Source="Nicolas_upshifts" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1364645 /Source="Nicolas_upshifts" /id="D788" /incds=0 /nref=132 /ntot=229 /MaxReadThrough="3.48305" /MaxDrop="4.61382" /score="32.6727777" /energy="-7.5" /TU="U1159" /idTUdmin="U1160" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(1364662..1364667) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1364715..1364722 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1364734..1364835 /Source="Nicolas_S_feature" /locus_tag="new_1483539_1483640" /HighExp="B36, B60, nit, Pyr, BI, HiOs, T-0.40H, S5, GM 15, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S512" upshifts 1364734 /Source="Nicolas_upshifts" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1364737..1364756 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" misc_RNA 1364752..1364835 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /product="regulatory RNA controlling iron-dependent metabolism" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629, 24576839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629, 24576839; Product type n: RNA" /function="12: Regulatory functions" /label="fsrA RNA" gene 1364752..1364835 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /label="fsrA gene" downshifts 1364792 /Source="Nicolas_upshifts" /id="D789" /incds=0 /nref=61 /ntot=192 /MaxReadThrough="6.41968" /MaxDrop="7.54463" /score="16.5898261" /energy="-8.8" /TU="U1159,U1162" /idTUdmin="U1159" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 1364846..1364851 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1364866..1365150 /Source="Nicolas_S_feature" /locus_tag="new_1483671_1483955" /HighExp="S4, H2O2, S5, Paraq, B60, nit, GM 10, B36, GM 25, GM 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147452" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S513" upshifts 1364866 /Source="Nicolas_upshifts" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1364868..1364886 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-10" promotor_-35 1365127..1365133 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" promotor_-10 1365147..1365158 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" S_feature 1365152..1365239 /Source="Nicolas_S_feature" /locus_tag="new_1483957_1484044" /HighExp="S5, S4, H2O2, B60, Paraq, nit, B36, GM 10, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigEF, SigA" /TUshortPSig="0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S514" upshifts 1365152 /Source="Nicolas_upshifts" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" misc_feature 1365228..1365247 /Source="Nicolas_upshift_promotors" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1365241 /Source="Nicolas_upshifts" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1365312..1365551 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16387657, 18436958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-specific modification enzyme subunit" /protein_id="NP_389293.1" /db_xref="EnsemblGenomes-Gn:BSU14100" /db_xref="EnsemblGenomes-Tr:CAB13283" /db_xref="InterPro:IPR014904" /db_xref="PDB:2FFG" /db_xref="SubtiList:BG13294" /db_xref="UniProtKB/Swiss-Prot:O34588" /translation="MSQLMGIITRLQSLQETAEAANEPMQRYFEVNGEKICSVKYFEK NQTFELTVFQKGEKPNTYPFDNIDMVSIEIFELLQ*" /label="ykuJ CDS" gene 1365312..1365551 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /label="ykuJ gene" S_feature 1365552..1365660 /Source="Nicolas_S_feature" /locus_tag="new_1484357_1484465" /HighExp="H2O2, LoTm, G135, Paraq, G180, LBGexp, G150, Oxctl, dia0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S515" CDS 1365661..1366179 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16165328, 24464998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding enzyme component" /protein_id="NP_389294.1" /db_xref="EnsemblGenomes-Gn:BSU14110" /db_xref="EnsemblGenomes-Tr:CAB13284" /db_xref="InterPro:IPR007405" /db_xref="SubtiList:BG13295" /db_xref="UniProtKB/Swiss-Prot:O34776" /translation="MADSFLFYNLSEAQMTFQDVMERLKAFVQKDPRSSYVLSIGTDS QVYRDYTKFITALHLHRTGKGAWGCLKNHTVDRPIHSLREKISLETAYSQETAAHILD GHLMDITDLLLPFTGEGADLTFEVHLDIGKKGLTKDLIQEMTGRITSMGIEAKIKPDS YTAFSYANRFTK*" /label="ykuK CDS" gene 1365661..1366179 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /label="ykuK gene" promotor_-35 1366216..1366223 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1366237..1366256 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1366251 /Source="Nicolas_upshifts" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1366313..1366510 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18840696, 24534728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18840696, 24534728; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of AbrB repressor" /protein_id="NP_389295.1" /db_xref="EnsemblGenomes-Gn:BSU14120" /db_xref="EnsemblGenomes-Tr:CAB13285" /db_xref="GOA:O31697" /db_xref="InterPro:IPR025446" /db_xref="PDB:2LZF" /db_xref="SubtiList:BG13334" /db_xref="UniProtKB/Swiss-Prot:O31697" /translation="MRMSLIGERFTEEEQKLLLNILINHEYAIELLSSEINDIETGTK NVDGTTYKKLVTLYDRFRFEN*" /label="abbA CDS" gene 1366313..1366510 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /label="abbA gene" downshifts 1366506 /Source="Nicolas_upshifts" /id="D790" /incds=0 /nref=114 /ntot=265 /MaxReadThrough="5.72556" /MaxDrop="4.65809" /score="2.45376472" /energy="-6.8" /TU="U1165,U1166" /idTUdmin="U1162" /TUdmin=12 /isTUend="TRUE" /label="downshifts" S_feature 1366551..1366647 /Source="Nicolas_S_feature" /locus_tag="new_1485356_1485452" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, M0t90, T1.0H, T5.0H, T2.30H, T1.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.23094000000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S516" CDS 1366648..1367091 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11985717; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA-binding protein" /protein_id="NP_389296.1" /db_xref="EnsemblGenomes-Gn:BSU14130" /db_xref="EnsemblGenomes-Tr:CAB13286" /db_xref="PDB:1YAV" /db_xref="SubtiList:BG13296" /db_xref="UniProtKB/Swiss-Prot:O31698" /translation="MISLQSDQLLEATVGQFMIEADKVAHVQVGNNLEHALLVLTKTG YTAIPVLDPSYRLHGLIGTNMIMNSIFGLERIEFEKLDQITVEEVMLTDIPRLHINDP IMKGFGMVINNGFVCVENDEQVFEGIFTRRVVLKELNKHIRSLNK*" /label="ykuL CDS" gene 1366648..1367091 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /label="ykuL gene" S_feature 1367092..1367199 /Source="Nicolas_S_feature" /locus_tag="new_1485897_1486004" /HighExp="M0t90, M40t90, M9-stat, T1.0H, T3.30H, T3.0H, T4.0H, S2, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S517" promotor_-35 1367167..1367172 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1367187..1367206 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1367201 /Source="Nicolas_upshifts" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1367240..1368121 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14636591, 16352834, 16395550, 23139400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636591, 16352834, 16395550, 23139400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of citB and citZ" /protein_id="NP_389297.1" /db_xref="EnsemblGenomes-Gn:BSU14140" /db_xref="EnsemblGenomes-Tr:CAB13287" /db_xref="GOA:O34827" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13297" /db_xref="UniProtKB/Swiss-Prot:O34827" /translation="MQLQELHMLVVLAEELNMRKAAERLFVSQPALSQRLQTIEKAWG TKIFLRSQKGLTVTPAGEKIIQFANDVTLEQERIRENIDELEGEIHGTLKLAVASIIG QHWLPKVLKTYVEKYPNAKISLITGWSSEMLKSLYEDQVHIGIIRGNPEWKGRKDYLM TDHLYLVDTEISCIEDIAHTERPFIQFKSDSTYFQEIQHWWHQKFKTSPKQTILVDQI ETCKQMALHGIGYAILPSVTLQNEDKVNKMPLLDMKGHPIGRDTWLLGYEPAFELKQV QAFVQVIKDMLDQENPF*" /label="ccpC CDS" gene 1367240..1368121 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /label="ccpC gene" downshifts 1368100 /Source="Nicolas_upshifts" /id="D791" /incds=0 /nref=168 /ntot=242 /MaxReadThrough="1.76921" /MaxDrop="5.2505" /score="37.6563581" /energy="-8.3" /TU="NA" /idTUdmin="U1165" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1368156..1368163 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1368178..1368197 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1368183 /Source="Nicolas_upshifts" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1368233..1368709 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin (acts in lipid desaturation)" /protein_id="NP_389298.1" /db_xref="EnsemblGenomes-Gn:BSU14150" /db_xref="EnsemblGenomes-Tr:CAB13288" /db_xref="GOA:O34737" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13298" /db_xref="UniProtKB/Swiss-Prot:O34737" /translation="MAKALITYASMSGNTEDIAFIIKDTLQEYELDIDCVEINDMDAS CLTSYDYVLIGTYTWGDGDLPYEAEDFFEEVKQIQLNGLKTACFGSGDYSYPKFCEAV NLFNVMLQEAGAAVYQETLKIELAPETDEDVESCRAFARGFLAWADYMNKEKIHVS*" /label="fldN CDS" gene 1368233..1368709 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /label="fldN gene" CDS 1368699..1369592 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12354229, 24214949" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389299.1" /db_xref="EnsemblGenomes-Gn:BSU14160" /db_xref="EnsemblGenomes-Tr:CAB13289" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG13299" /db_xref="UniProtKB/Swiss-Prot:O34879" /translation="MFHKGATAVTASAFSGYFVAVQREGIFHYSLEQGWRKLFRLKSK IHCISYIGPYLFGVGEKGTVIRSADEGKTWTMSSFPTNATVWAITGRNNGFVCAHGKH CIYVSDDFGVSWRVAKPFAEFHNPPVIRSLCLHGGNLFIGTQIHEYFGGIWAYDIKRD TVQVVKKEKNRMTASMLVFNENWLVAAMGSVKGKHGAVTVRNLLNGEEFTIQSSMIRN EESFLDLSEDDGIIYVTTTQDENGFSRIYQVDLEARSLKWFDTIKGHGWRVANQKENF FCAGLYECKFVQPYEVSAMIH*" /label="ykuO CDS" gene 1368699..1369592 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /label="ykuO gene" CDS 1369608..1370063 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin" /protein_id="NP_389300.2" /db_xref="EnsemblGenomes-Gn:BSU14170" /db_xref="EnsemblGenomes-Tr:CAB13290" /db_xref="GOA:O34589" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001226" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13300" /db_xref="UniProtKB/Swiss-Prot:O34589" /translation="MAKILLVYATMSGNTEAMADLIEKGLQEALAEVDRFEAMDIDDA QLFTDYDHVIMGTYTWGDGDLPDEFLDLVEDMEEIDFSGKTCAVFGSGDTAYEFFCGA VDTLEAKIKERGGDIVLPSVKIENNPEGEEEEELINFGRQFAKKSGCAV*" /label="fldP CDS" gene 1369608..1370063 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /label="fldP gene" promotor_-10 complement(1369879..1369898) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1369892) /Source="Nicolas_upshifts" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1369912..1369920) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1370057 /Source="Nicolas_upshifts" /id="D792" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="6.48855" /MaxDrop="3.75748" /score="20.7202933" /energy="-9" /TU="U1168" /idTUdmin="U1165" /TUdmin=1957 /isTUend="FALSE" /label="downshifts" promotor_-35 1370102..1370109 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1370123..1370142 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1370124 /Source="Nicolas_upshifts" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1370168..1370878 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /EC_number="2.3.1.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5411754, 10368155, 11910040, 12682299, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5411754, 10368155, 11910040, 12682299, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetrahydrodipicolinate N-acetyltransferase" /protein_id="NP_389301.2" /db_xref="EnsemblGenomes-Gn:BSU14180" /db_xref="EnsemblGenomes-Tr:CAB13291" /db_xref="GOA:O34981" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR013710" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR019873" /db_xref="SubtiList:BG13301" /db_xref="UniProtKB/Swiss-Prot:O34981" /translation="MKMMDANEIISFIQNSTKSTPVKVYVKGELEGINFGESAKAFIN GNTGVVFGEWSEIQTAIEENQSKIEDYVVENDRRNSAIPMLDLKNIKARIEPGAIIRD QVEIGDNAVIMMGASINIGSVIGEGTMIDMNVVLGGRATVGKNCHIGAGSVLAGVIEP PSAKPVVIEDDVVIGANAVVLEGVTVGKGAVVAAGAIVVNDVEPYTVVAGTPAKKIKD IDEKTKGKTEIKQELRQL*" /label="dapH CDS" gene 1370168..1370878 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /label="dapH gene" downshifts complement(1370177) /Source="Nicolas_upshifts" /id="D793" /incds=0 /nref=60 /ntot=165 /MaxReadThrough="1.03272" /MaxDrop="4.75802" /score="28.9046709" /energy="-15" /TU="NA" /idTUdmin="U1171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1370287..1370291) /Source="Nicolas_upshift_promotors" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1370287) /Source="Nicolas_upshifts" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1370948..1372072 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /EC_number="3.5.1.47" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14627808, 17093042, 24261876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14627808, 17093042, 24261876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-diaminopimelate deacetylase" /protein_id="NP_389302.1" /db_xref="EnsemblGenomes-Gn:BSU14190" /db_xref="EnsemblGenomes-Tr:CAB13292" /db_xref="GOA:O34916" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR023905" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13302" /db_xref="UniProtKB/Swiss-Prot:O34916" /translation="MKIEELIAIRRDLHRIPELGFQEFKTQQYLLNVLEQYPQDRIEI EKWRTGLFVKVNGTAPEKMLAYRADIDALSIEEQTGLPFASEHHGNMHACGHDLHMTI ALGIIDHFVHHPVKHDLLFLFQPAEEGPGGAEPMLESDVLKKWQPDFITALHIAPELP VGTIATKSGLLFANTSELVIDLEGKGGHAAYPHLAEDMVVAASTLVTQLQTIISRNTD PLDSAVITVGTITGGSAQNIIAETAHLEGTIRTLSEESMKQVKERIEDVVKGIEIGFR CKGKVTYPSVYHQVYNTSGLTEEFMSFVAEHQLATVIEAKEAMTGEDFGYMLKKYPGF MFWLGADSEHGLHHAKLNPDENAIETAVHVMTGYFSVYAN*" /label="dapI CDS" gene 1370948..1372072 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /label="dapI gene" promotor_-35 1372084..1372090 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1372104..1372115 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1372106 /Source="Nicolas_upshifts" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1372110..1372124) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1372134..1372138) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1372134..1372379 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389303.1" /db_xref="EnsemblGenomes-Gn:BSU14200" /db_xref="EnsemblGenomes-Tr:CAB13293" /db_xref="InterPro:IPR005370" /db_xref="SubtiList:BG13303" /db_xref="UniProtKB/Swiss-Prot:O34783" /translation="MAKKIGIEQSLSDVEAALKEKGYDVVMMKSPADAQGCDCCVVTG LDNNVQGIADTVTQAPVITASGMTAEEICSEVESRIQ*" /label="ykuS CDS" gene 1372134..1372379 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /label="ykuS gene" upshifts complement(1372135) /Source="Nicolas_upshifts" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1372367 /Source="Nicolas_upshifts" /id="D794" /incds=0 /nref=238 /ntot=269 /MaxReadThrough="3.49553" /MaxDrop="5.88829" /score="3.56597112" /energy="-9.9" /TU="U1172" /idTUdmin="U1168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1372412..1373362 /Source="Nicolas_S_feature" /locus_tag="new_1491217_1492167" /HighExp="S4, S5, S6, S3, S7, S8, LoTm, BT, B36, G135" /AntisenseName="ykuT" /AntisenseCor="-0.479447808227356" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S518" CDS complement(1372416..1373219) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /function="16.6: Maintain" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12626684, 17665170, 18310427, 19252899, 21150093" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12626684, 17665170, 18310427, 19252899, 21150093; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small-conductance mechanosensitive channel" /protein_id="NP_389304.2" /db_xref="EnsemblGenomes-Gn:BSU14210" /db_xref="EnsemblGenomes-Tr:CAB13294" /db_xref="GOA:O34897" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13304" /db_xref="UniProtKB/Swiss-Prot:O34897" /translation="MDFIKQYDWAGLITNAGVLLIKLAIMILLYFIVRSLGMKIIKHL FAKFEEQNSLSIGRAHTLRSLTLNIFAYTLIFIFFVMVLDLFHYDPSALLAGAGIVGL AVGFGAQGLVSDIVTGFFILLEKQLDVGDYITVSTFDGIVEQVGLRTTQIRSFDGTLH YIPNRNITNVSNHSRGTMQALVDIKVPAERNIDEMIHILQQVCDETAAALPQIKEGPN VIGIQELGTSEIVIRVIAKTENMEQWRVERVLRKEIKNAFDRAFPKETE*" /label="mscT CDS" gene complement(1372416..1373219) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /label="mscT gene" downshifts complement(1372428) /Source="Nicolas_upshifts" /id="D795" /incds=0 /nref=16 /ntot=131 /MaxReadThrough="1.65551" /MaxDrop="4.4361" /score="29.0050313" /energy="-9.9" /TU="NA" /idTUdmin="U1174" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1373270..1373289) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1373279) /Source="Nicolas_upshifts" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1373303..1373310) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1373335..1373342 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-35" promotor_-10 1373357..1373376 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-10" S_feature 1373364..1373455 /Source="Nicolas_S_feature" /locus_tag="new_1492169_1492260" /HighExp="LPhT, Salt, Etha, M9-stat, M0t90, T4.0H, T5.0H, S4, Heat, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S519" upshifts 1373364 /Source="Nicolas_upshifts" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="upshifts" CDS 1373456..1373998 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /EC_number="1.11.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:22938038, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22938038, 27683249; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biofilm-specific peroxidase; 2-cys peroxiredoxin" /protein_id="NP_389305.1" /db_xref="EnsemblGenomes-Gn:BSU14220" /db_xref="EnsemblGenomes-Tr:CAB13295" /db_xref="GOA:O34564" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13305" /db_xref="UniProtKB/Swiss-Prot:O34564" /translation="MAERMVGKQAPRFEMEAVLASKEFGKVSLEENMKNDKWTVLFFY PMDFTFVCPTEITAMSDRYDEFEDLDAEVIGVSTDTIHTHLAWINTDRKENGLGQLKY PLAADTNHEVSREYGVLIEEEGVALRGLFIINPEGELQYQTVFHNNIGRDVDETLRVL QALQTGGLCPANWKPGQKTL*" /label="ahpA CDS" gene 1373456..1373998 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /label="ahpA gene" CDS 1374070..1374516 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /EC_number="1.8.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15937154, 16132829, 16418167" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 16132829, 16418167; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_389306.2" /db_xref="EnsemblGenomes-Gn:BSU14230" /db_xref="EnsemblGenomes-Tr:CAB13296" /db_xref="GOA:O31699" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:2B5X" /db_xref="PDB:2B5Y" /db_xref="SubtiList:BG13306" /db_xref="UniProtKB/Swiss-Prot:O31699" /translation="MKLRQPMPELTGEKAWLNGEVTREQLIGEKPTLIHFWSISCHLC KEAMPQVNEFRDKYQDQLNVVAVHMPRSEDDLDPGKIKETAAEHDITQPIFVDSDHAL TDAFENEYVPAYYVFDKTGQLRHFQAGGSGMKMLEKRVNRVLAETE*" /label="ykuV CDS" gene 1374070..1374516 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /label="ykuV gene" downshifts 1374524 /Source="Nicolas_upshifts" /id="D796" /incds=0 /nref=58 /ntot=211 /MaxReadThrough="3.11112" /MaxDrop="4.73023" /score="10.8864177" /energy="-5.4" /TU="U1175" /idTUdmin="U1172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1374909..1374916 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1374929 /Source="Nicolas_upshifts" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1374931..1374950 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1374982..1375557 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 27902860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 27902860; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of comK" /protein_id="NP_389307.1" /db_xref="EnsemblGenomes-Gn:BSU14240" /db_xref="EnsemblGenomes-Tr:CAB13297" /db_xref="GOA:O34857" /db_xref="SubtiList:BG13307" /db_xref="UniProtKB/Swiss-Prot:O34857" /translation="MFNEREALRLRLEQLNEAEVKVIREYQIERDKIYAKLRELDRNG SPSEIKKDFRSEKKPDSLPVLAELAAQEIRSYQPQSQQQSVQPQLQSISSLPAGIPDG TTRRRRGTARPGSKAAKLREAAIKTLKRHNAAIKSSELQKEIEKESGLEIPNMTTFMQ SLIKMYPEVKKPYRGQYILEGEIESAESANE*" /label="rok CDS" gene 1374982..1375557 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /label="rok gene" downshifts 1375535 /Source="Nicolas_upshifts" /id="D797" /incds=0 /nref=246 /ntot=258 /MaxReadThrough="1.77207" /MaxDrop="6.35121" /score="17.7584572" /energy="-9" /TU="NA" /idTUdmin="U1176" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1375598..1376563) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /experiment="publication(s) with functional evidences, PMID:8990290, 15383836, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 15383836, 15743949; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein cse15" /protein_id="NP_389308.1" /db_xref="EnsemblGenomes-Gn:BSU14250" /db_xref="EnsemblGenomes-Tr:CAB13298" /db_xref="GOA:O31700" /db_xref="SubtiList:BG12251" /db_xref="UniProtKB/Swiss-Prot:O31700" /translation="MKRSGPFFHDVSQENLYLKSELSRCHKLISELEASYFHQKNNKL LKENTDMKEKLQQLSAELTHMSTKEKHASHTSQTLHQIRAELLDKIVVLQELLSAETY KRRAEIEEKHKLHIAKVKIEEENKNLHKRISELQASIEQEQNALLQAKQQAELIKAEN GRLKEQMVEKEYQLKHIKIEVDHMKDRIIETKERLLDIEKTKEKLFHETIISYKRQLD ESDAWIASHFADIDGGTKQKEKTEEEAPAAYAQPNHVETILEDVTKQIHVLQKQLAHA QSSDQAKSHTIEELKNRAAEEKPYQKWVYKLNLEKENKPSQKKPQ*" /label="sppO CDS" gene complement(1375598..1376563) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /label="sppO gene" downshifts complement(1375611) /Source="Nicolas_upshifts" /id="D798" /incds=0 /nref=47 /ntot=67 /MaxReadThrough="2.24884" /MaxDrop="5.5936" /score="3.60334458" /energy="-7.2" /TU="NA" /idTUdmin="U1178" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1375907..1375908 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1375926..1375945 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1375932..1376656 /Source="Nicolas_S_feature" /locus_tag="new_1494737_1495461" /HighExp="dia15, Diami, dia5, H2O2, G135, G150, G180, LBGexp, Paraq, Lbexp" /AntisenseName="yknT" /AntisenseCor="-0.36512493899072102" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S520" upshifts 1375932 /Source="Nicolas_upshifts" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1376584..1376602) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1376605) /Source="Nicolas_upshifts" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1376617..1376622) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1376643..1376649 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1376659 /Source="Nicolas_upshifts" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1376663..1376682 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1376700..1377299 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /EC_number="2.7.7.77" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10978347; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein A" /protein_id="NP_389309.1" /db_xref="EnsemblGenomes-Gn:BSU14260" /db_xref="EnsemblGenomes-Tr:CAB13299" /db_xref="GOA:O31701" /db_xref="InterPro:IPR013482" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12621" /db_xref="UniProtKB/Swiss-Prot:O31701" /translation="MKHVNVLLAGGASRRFGEPKAFVKWKGRMLYECAKEALGEQTVI ISRPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKTDGDLYTVLSCDTPLIQR RTMLELKRLMIAGADAVVPISDGQVQPLIAIYHKRIMPVLYDQLSEKRLRISDLLGRI SVCYVQAENIGANPAEFININTRDDFSCLEEKSNSLKRD*" /label="mobA CDS" gene 1376700..1377299 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /label="mobA gene" CDS 1377350..1378369 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /EC_number="2.7.7.80" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17223713; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin biosynthesis adenylyltransferase" /protein_id="NP_389310.1" /db_xref="EnsemblGenomes-Gn:BSU14270" /db_xref="EnsemblGenomes-Tr:CAB13300" /db_xref="GOA:O31702" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG12624" /db_xref="UniProtKB/Swiss-Prot:O31702" /translation="MEERYSRQIRFKQIGEEGQKRLADSHVLIVGAGALGTAGAEGLS RAGVGTITIIDRDYVEWSNLQRQQLYTESDAKLRMPKAMAAKEHLSAINSEIHIEAYV TEGTAETLEPLIEKADVVIDATDNFETRMLINDLAQKTKTPWVYGACVSSQGMFMTVI PGETPCLSCLFEQIPVGGATCDTAGIIPPAVHIVSAYQQAEALKLLTGQKEAIQRGFV TFDVWNNSHMKINVNHVRREECPSCGANAVYPYLQDWNTPKAAVLCGRDTVQVRSESL KRIPKQELIKRLKTIGKVEANAFLLHIFYEDFRIVIFNDGRALVHGTNDVKEANSVLA RVIGL*" /label="moeB CDS" gene 1377350..1378369 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /label="moeB gene" CDS 1378387..1379679 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /EC_number="2.10.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11428898, 12006571, 18959753, 21206014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdate to molybdopterin ligation enzyme" /protein_id="NP_389311.1" /db_xref="EnsemblGenomes-Gn:BSU14280" /db_xref="EnsemblGenomes-Tr:CAB13301" /db_xref="GOA:O31703" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR005110" /db_xref="InterPro:IPR005111" /db_xref="InterPro:IPR036135" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036688" /db_xref="SubtiList:BG12623" /db_xref="UniProtKB/Swiss-Prot:O31703" /translation="MLEKRTPIPVDEAVRRVCHFQKQGETEWVALEDSLHRFLAEDIT ADHHVPAFDRSPYDGFAVRACDTAEASRENPVRFEVIDHIGAGAVSEKELGPFQAVRI MTGAQIPEGADAVVMIELTQAFEENGKSFMSLKRRFQTGDNISKTGEDAQKGSVLLTK GTRVTPGVTALLATFGYASVPVVRKPVVGIIATGTELLNVSDPLEPGKIRNSNASMVY AQAIEAGATPLYLGKISDELDKSFAAVKEAMKKVDFLITTGGVSVGDFDFLPAIYEKL GADVLFNKVAMRPGSVTTVAHANDMLLFGLSGNPSACYVGFELFVKPIIQTWLLNETP HSICAEAVLTKDFPKPNPFTRFVRALVHHQEGKLLATPVGLDKSSSVTSLADANAFII LPGGTRGYESGRTVQVLLIREENGSEWPWSVLSRSSKL*" /label="moeA CDS" gene 1378387..1379679 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /label="moeA gene" CDS 1379640..1380161 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9219527, 12682065, 12719427; Product type c: carrier" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein B" /protein_id="NP_389312.1" /db_xref="EnsemblGenomes-Gn:BSU14290" /db_xref="EnsemblGenomes-Tr:CAB13302" /db_xref="GOA:O31704" /db_xref="InterPro:IPR004435" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12622" /db_xref="UniProtKB/Swiss-Prot:O31704" /translation="MALVRPFPIVQVVGFQNSGKTTFIERILEKASEQGVHLGCLKHH GHGGEPQTLTEGKDTDRYKAAGADVTAVEGAGVLQLTARRNWDLARLIELYQFLETDC LLIEGFKKAPYPKVVILSEKEDLEALQAVNIIAIIYRKKEHMTEHQGLPVFHADDPVA VDFVLSQLKGESA*" /label="mobB CDS" gene 1379640..1380161 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /label="mobB gene" CDS 1380161..1380634 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /EC_number="2.8.1.12" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 18092812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (large subunit)" /protein_id="NP_389313.1" /db_xref="EnsemblGenomes-Gn:BSU14300" /db_xref="EnsemblGenomes-Tr:CAB13303" /db_xref="GOA:O31705" /db_xref="InterPro:IPR003448" /db_xref="InterPro:IPR036563" /db_xref="SubtiList:BG12620" /db_xref="UniProtKB/Swiss-Prot:O31705" /translation="MERFEITKTPINTENIIKKVEKREAGAITTFIGTVREWTNGKRT VRLEYEAYEPMAVQMLAQIGAEIEEKWEGASAAITHRIGVLDIGEAAVVIAVSSPHRK AAYEANEYAIERIKQIVPIWKKEIWEDGEQWIGDQLETTAYPNGKPDLSEGEQHD*" /label="moaE CDS" gene 1380161..1380634 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /label="moaE gene" CDS 1380627..1380860 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 17223713, 19946146; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (small subunit)" /protein_id="NP_389314.1" /db_xref="EnsemblGenomes-Gn:BSU14310" /db_xref="EnsemblGenomes-Tr:CAB13304" /db_xref="GOA:O31706" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010034" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="SubtiList:BG12619" /db_xref="UniProtKB/Swiss-Prot:O31706" /translation="MIKILLFAGLAEQAGTQAIEIDMEQATTDEIKASLKEQYGLESI DTAMIAVNESYVKENTSVSSGDTVAIIPPVSGG*" /label="moaD CDS" gene 1380627..1380860 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /label="moaD gene" downshifts 1380839 /Source="Nicolas_upshifts" /id="D799" /incds=0 /nref=87 /ntot=240 /MaxReadThrough="1.14308" /MaxDrop="5.73073" /score="32.0123217" /energy="-16.9" /TU="NA" /idTUdmin="U1177" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1380905..1380910 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-35" promotor_-10 1380927..1380945 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-10" upshifts 1380935 /Source="Nicolas_upshifts" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="upshifts" S_feature 1380947..1381033 /Source="Nicolas_S_feature" /locus_tag="new_1499752_1499838" /HighExp="S4, S5, S3, T5.0H, T4.0H, Pyr, S6, T3.30H, M9-stat, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S521" promotor_-35 1381023..1381026 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1381035 /Source="Nicolas_upshifts" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1381041..1381060 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1381084..1382841 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389315.1" /db_xref="EnsemblGenomes-Gn:BSU14320" /db_xref="EnsemblGenomes-Tr:CAB13305" /db_xref="GOA:O31707" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13241" /db_xref="UniProtKB/Swiss-Prot:O31707" /translation="METFKRLKMYYWPYRKVFMWSLLAMLLMTAITVVYPIILQITID EIVLGRQYQLAAWVSLGFIAVMVLKGMATFFHQYLGDMFGIKSVYRLRNGLYEKLQRL SFSYYDNAKTGDLMSRLTADVEGLRFFLSYGLAELIRFGLLVAISLSVMFYYSVPLTL VTIAVLPFLAVAVYRFDKRVHPAFRGIRKSFAKLNTKVQENISGINTVKSLSREDFQI STFNKANAEYRAQYLQTSSIWSAYFPLMEFIGNTCIVALLSYGGYLVMQNQLNPGELV AFFSLVNYMMWPIMNLGFVINMFSQAKASGERLLDILEKEEDITDHPHALHKQKLTGD VHFKNVSLAYGKEQTNALCNVSFEANSGKVIGLLGPTGSGKSSVTQLLTRFYSPVGGM ITIDHKPITDYSLKTLRSNIGVVLQESFLFSSTIRSNISYGRPDASMEDVIEAAKRAQ AHNFIMELPDGYDTMLGERGMGLSGGQKQRIAIARAICLNPSILILDDATSAVDMQTE HSIQLALKEVMKNRTTFIVAHRISSLKHADEILVFNKGRIRERGTHHELLEKGGYYKK IYDLQYRDVKMINEPHEVG*" /label="yknU CDS" gene 1381084..1382841 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /label="yknU gene" CDS 1382853..1384667 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389316.1" /db_xref="EnsemblGenomes-Gn:BSU14330" /db_xref="EnsemblGenomes-Tr:CAB13306" /db_xref="GOA:O31708" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13242" /db_xref="UniProtKB/Swiss-Prot:O31708" /translation="MKQAKKQGVLERFYYSSDEIIEKPFNWAQMWRLLSYVKPYRKTI LPLSFLTVLIGTAVKLVIPILIGVYVLDQAITGRNSELLIQLIFIISGLYVLNYAANV LRIRWMNQLGQHVIYDLRQHLFTHVQRLSHRFFDQRSAGSILVRIMNDINSLQELFTS GVINLLTDLLLLAGVIIILFTLSPELTIAIMVTLPIMFFISTSLRKKIRRSWQTVRLK QSKLNSHLNESIQGIRVTQAFTQEEENMAYFDGVNQENYESWREATRKNAMFRPLVEM TNAIGTAVLIWYGATLIMNETITIGVFVSFAFYLGMFWEPISRLGQVYNQLLMGMASS ERIFEFLDEQPNVKEKPNAIHNEKINGEISFEEVEFSYDEKRKALHAVSFSIPAGSTL ALVGHTGSGKTTIANLISRFYDAAGGTIKIDGIPIKDLSLASLRSQISIVLQDTFIFS GTIMENIRFGRPNASDEEVMKASQAVGADEFISDLAEGYATEVEERGSVLSAGQRQLI SFARALLADPAIIILDEATASIDTETEVKIQQALKTLLKGRTAVMIAHRLSTIRDADR IIVLDHGRKIEEGNHDQLLAKGGIYAGLVKAQYSTAIE*" /label="yknV CDS" gene 1382853..1384667 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /label="yknV gene" promotor_-10 complement(1383290..1383309) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1383300) /Source="Nicolas_upshifts" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1383324..1383331) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1384718..1384727 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1384739..1384754 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1384743 /Source="Nicolas_upshifts" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="upshifts" CDS 1384777..1385472 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of permease exporting the starvation-induced killing protein" /protein_id="NP_389317.1" /db_xref="EnsemblGenomes-Gn:BSU14340" /db_xref="EnsemblGenomes-Tr:CAB13307" /db_xref="GOA:O31709" /db_xref="InterPro:IPR006977" /db_xref="SubtiList:BG13243" /db_xref="UniProtKB/Swiss-Prot:O31709" /translation="METNVEKNSGTATEKPSLFGVITSPSVQFERIRERPAVWGPLLI VAAIIIVGAVLQSLGTDYSELLKSQDTQGLSAEQMETVATITKFGGMAGAIIGGIAAL FIAPLIYWLCVKVSGGVTTYKKMLSLSLFVSLISSLGLLVNGIVAFTTDVNPLYSTTS LAGIIPSDGALASVLNTFEIFSIWSFVLLAIGLHKTGGISKKAGWISAIILFGILVVF SLFSGLINSVAGA*" /label="skiW CDS" gene 1384777..1385472 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /label="skiW gene" CDS 1385477..1386610 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11544226, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544226, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein" /protein_id="NP_389318.1" /db_xref="EnsemblGenomes-Gn:BSU14350" /db_xref="EnsemblGenomes-Tr:CAB13308" /db_xref="GOA:O31710" /db_xref="InterPro:IPR006143" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG13244" /db_xref="UniProtKB/Swiss-Prot:O31710" /translation="MKKVWIGIGIAVIVALFVGINIYRSAAPTSGSAGKEVQTGSVEE NEISSTVMVPGTLKFSNEQYVFYEADKGTLEDIKVKEGDKVKKGTALVTYTNEQLSLE KEQNQLTSESNRLQIDQIQEKLKALDSKERELEKQVGKKEAEKQIESERTELQMQKKT AEIELKQTELQRQSLANRVSDLEVKSEIEGTVISVNQEAASKKSDIQEPVIHIGNPKD LVVSGKLSEYDTLKVKKGQKVTLTSDVIQGKTWKGTVSAVGLVPDQQESAAAQGTEQA VQYPLQVKIKGNLPEGKPGFKFIMNIETDKRKANTLPSKAVKKEDDQYYVYTVKDGKA KRVDVKIGEVTDDLTEIKEGLTQDDQVILNPSDQVTDGMEVKS*" /label="skiX CDS" gene 1385477..1386610 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /label="skiX gene" CDS 1386611..1387303 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein (ATP-binding protein)" /protein_id="NP_389319.1" /db_xref="EnsemblGenomes-Gn:BSU14360" /db_xref="EnsemblGenomes-Tr:CAB13309" /db_xref="GOA:O31711" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13245" /db_xref="UniProtKB/Swiss-Prot:O31711" /translation="MIQLSNVRKSYQIGKETFDVLHSIDLDIHQGEYVSIMGPSGSGK STIMNIIGCLDRPTSGTYQLDGEDISSYKDKELAAVRNRSIGFVFQQFQLLPRLNAKK NVELPMIYSGIGKKERQERAERALEKVGLADRMLHMPNELSGGQKQRVAIARAIVNEP KLILADEPTGALDTKTSEAIMDQFTALNAEGTTIVLVTHEPEVADCTNRIVMVRDGNI VPASSGQRSVGE*" /label="skiY CDS" gene 1386611..1387303 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /label="skiY gene" CDS 1387300..1388493 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703, 22720735, 27243566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703, 22720735, 27243566; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease subunit exporting Sporulation-Delaying Protein" /protein_id="NP_389320.1" /db_xref="EnsemblGenomes-Gn:BSU14370" /db_xref="EnsemblGenomes-Tr:CAB13310" /db_xref="GOA:O31712" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR005085" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13246" /db_xref="UniProtKB/Swiss-Prot:O31712" /translation="MSLLENIRMALSSVLAHKMRSILTMLGIIIGVGSVIVVVAVGQG GEQMLKQSISGPGNTVELYYMPSDEELASNPNAAAESTFTENDIKGLKGIEGIKQVVA STSESMKARYHEEETDATVNGINDGYMNVNSLKIESGRTFTDNDFLAGNRVGIISQKM AKELFDKTSPLGEVVWINGQPVEIIGVLKKVTGLLSFDLSEMYVPFNMMKSSFGTSDF SNVSLQVESADDIKSAGKEAAQLVNDNHGTEDSYQVMNMEEIAAGIGKVTAIMTTIIG SIAGISLLVGGIGVMNIMLVSVTERTREIGIRKSLGATRGQILTQFLIESVVLTLIGG LVGIGIGYGGAALVSAIAGWPSLISWQVVCGGVLFSMLIGVIFGMLPANKAAKLDPIE ALRYE*" /label="skiZ CDS" gene 1387300..1388493 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /label="skiZ gene" downshifts 1388471 /Source="Nicolas_upshifts" /id="D800" /incds=0 /nref=79 /ntot=210 /MaxReadThrough="3.49546" /MaxDrop="4.46952" /score="36.2703425" /energy="-12.1" /TU="U1183" /idTUdmin="U1183" /TUdmin="-396" /isTUend="FALSE" /label="downshifts" promotor_-35 1388542..1388548 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1388562..1388573 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1388570 /Source="Nicolas_upshifts" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1388615..1388622 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-35" promotor_-10 1388637..1388656 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-10" S_feature 1388642..1388733 /Source="Nicolas_S_feature" /locus_tag="new_1507447_1507538" /HighExp="UNK1, LPh, HPh, Fru, G180, MG 5, C30, G135, MG t5, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigWXY" /TUshortPSig="0.967, 0.86, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S522" upshifts 1388642 /Source="Nicolas_upshifts" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="upshifts" promotor_-35 1388697..1388704 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1388718..1388737 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1388735 /Source="Nicolas_upshifts" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="upshifts" CDS 1388773..1389528 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563858; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (DeoR family)" /protein_id="NP_389321.1" /db_xref="EnsemblGenomes-Gn:BSU14380" /db_xref="EnsemblGenomes-Tr:CAB13311" /db_xref="GOA:O31713" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12589" /db_xref="UniProtKB/Swiss-Prot:O31713" /translation="MLTPERHQLIIDQIEKHDVVKIQELINLTNASESTIRRDLSTLE ERGFLKRVHGGAAKLSDIRLEPDMLEKSSKNLHDKLKIAEKAASLLEEGDCIYLDAGT TTLHMIDFMDKTKDIVVVTNGVMHIDALIRKEISFYLLGGYVKHRTGAIIGGASLVAM DQYRFDKSFLGTNGVHTEAGFTTPDPDEALLKQKAIKQAKHAYVLADPSKFGEISFSA FAGIGDATIITTDAEELTFDNYQEKTVVKVVKP*" /label="fruR CDS" gene 1388773..1389528 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /label="fruR gene" upshifts complement(1388921) /Source="Nicolas_upshifts" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1388923..1388925) /Source="Nicolas_upshift_promotors" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1389525..1390436 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /EC_number="2.7.1.56" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 168069, 14563858, 24328040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1-phosphate kinase" /protein_id="NP_389322.1" /db_xref="EnsemblGenomes-Gn:BSU14390" /db_xref="EnsemblGenomes-Tr:CAB13312" /db_xref="GOA:O31714" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR017583" /db_xref="InterPro:IPR022463" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12588" /db_xref="UniProtKB/Swiss-Prot:O31714" /translation="MIYTVTLNPSVDYIVHVEDFTVGGLNRSSYDTKYPGGKGINVSR LLKRHHVASKALGFVGGFTGEYIKTFLREENLETAFSEVKGDTRINVKLKTGDETEIN GQGPTISDEDFKAFLEQFQSLQEGDIVVLAGSIPSSLPHDTYEKIAEACKQQNARVVL DISGEALLKATEMKPFLMKPNHHELGEMFGTAITSVEEAVPYGKKLVEQGAEHVIVSM AGDGALLFTNEAVYFANVPKGKLVNSVGAGDSVVAGFLAGISKQLPLEEAFRLGVTSG SATAFSEELGTEEFVQQLLPEVKVTRL*" /label="fruK CDS" gene 1389525..1390436 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /label="fruK gene" CDS 1390451..1392358 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /EC_number="2.7.1.202" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:118007, 200418" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 118007, 200418; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIABC component" /protein_id="NP_389323.1" /db_xref="EnsemblGenomes-Gn:BSU14400" /db_xref="EnsemblGenomes-Tr:CAB13313" /db_xref="GOA:P71012" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003353" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004715" /db_xref="InterPro:IPR006327" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="PDB:2R4Q" /db_xref="SubtiList:BG11938" /db_xref="UniProtKB/Swiss-Prot:P71012" /translation="MKITELLTKHTIKLNIESKEKENVIDEMVTVLDKAGKLNDRQAY KEAILNRESQSSTGIGEGIAIPHAKTASVINPAIAFGRSKDGVDYESLDGQPAHLVFM IAATEGANNTHLEALSRLSTLLMREEIRKQLLEAESEDAIIDIINQHDKDDDEEEEEE EAAPAPAGKGKILAVTACPTGIAHTFMAADALKEKAKELGVEIKVETNGSSGIKHKLT AQEIEDAPAIIVAADKQVEMERFKGKRVLQVPVTAGIRRPQELIEKAMNQDAPIYQGS GGGSAASNDDEEAKGKSGSGIGNTFYKHLMSGVSNMLPFVVGGGILVAISFFWGIHSA DPNDPSYNTFAAALNFIGGDNALKLIVAVLAGFIAMSIADRPGFAPGMVGGFMATQAN AGFLGGLIAGFLAGYVVILLKKVFTFIPQSLDGLKPVLIYPLFGIFITGVLMQFVVNT PVAAFMNFLTNWLESLGTGNLVLMGIILGGMMAIDMGGPLNKAAFTFGIAMIDAGNYA PHAAIMAGGMVPPLGIALATTIFRNKFTQRDREAGITCYFMGAAFVTEGAIPFAAADP LRVIPAAVVGAAVAGGLTEFFRVTLPAPHGGVFVAFITNHPMLYLLSIVIGAVVMAII LGIVKKPVTEK*" /label="fruA CDS" gene 1390451..1392358 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /label="fruA gene" downshifts 1392343 /Source="Nicolas_upshifts" /id="D801" /incds=0 /nref=133 /ntot=228 /MaxReadThrough="3.99928" /MaxDrop="5.27169" /score="11.7516734" /energy="-11.4" /TU="U1185" /idTUdmin="U1186" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1392427..1392434 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1392445..1392464 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1392448 /Source="Nicolas_upshifts" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="upshifts" CDS 1392503..1393084 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11283286, 11807061, 12897006, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11283286, 11807061, 12897006, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_389324.1" /db_xref="EnsemblGenomes-Gn:BSU14410" /db_xref="EnsemblGenomes-Tr:CAB13314" /db_xref="GOA:P71013" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11977" /db_xref="UniProtKB/Swiss-Prot:P71013" /translation="MTEEKNTNTEKTAKKKTNTYLEWGKAIVIAVLLALLIRHFLFEP YLVEGSSMYPTLHDGERLFVNKTVNYIGELKRGDIVIINGETSKIHYVKRLIGKPGET VQMKDDTLYINGKKVAEPYLSKNKKEAEKLGVSLTGDFGPVKVPKGKYFVMGDNRLNS MDSRNGLGLIAEDRIVGTSKFVFFPFNEMRQTK*" /label="sipT CDS" gene 1392503..1393084 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /label="sipT gene" downshifts 1393069 /Source="Nicolas_upshifts" /id="D802" /incds=0 /nref=90 /ntot=226 /MaxReadThrough="3.7981" /MaxDrop="6.13957" /score="5.03270493" /energy="-9.8" /TU="U1188" /idTUdmin="U1188" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1393113 /Source="Nicolas_upshifts" /id="D803" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.6676" /MaxDrop="3.60225" /score="5.03270493" /energy="-9.8" /TU="NA" /idTUdmin="U1188" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1393118..1393387) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389325.1" /db_xref="EnsemblGenomes-Gn:BSU14420" /db_xref="EnsemblGenomes-Tr:CAB13315" /db_xref="GOA:O31715" /db_xref="SubtiList:BG13247" /db_xref="UniProtKB/Swiss-Prot:O31715" /translation="MRLLTLTEYCLLIFFTGFYLAVTGFTAKDIGLYIGIALIYIFSH IFSKRLLEKRGKENKQVHLFFSVLAIIGSVFITVLCIALVASFSK*" /label="ykoA CDS" gene complement(1393118..1393387) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /label="ykoA gene" downshifts complement(1393123) /Source="Nicolas_upshifts" /id="D804" /incds=0 /nref=38 /ntot=254 /MaxReadThrough="2.08491" /MaxDrop="5.70938" /score="11.210199" /energy="-9.8" /TU="U1189" /idTUdmin="U1189" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(1393388..1393453) /Source="Nicolas_S_feature" /locus_tag="new_1512193_1512258_c" /HighExp="LoTm, Gly, Lbstat, Sw, Cold, C30, HPh, S0, T0.30H, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S523" misc_feature complement(1393434..1393453) /Source="Nicolas_upshift_promotors" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1393453) /Source="Nicolas_upshifts" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1393506..1393513 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1393524..1393543 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1393528 /Source="Nicolas_upshifts" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="upshifts" CDS 1393568..1395190 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10816464, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_389326.1" /db_xref="EnsemblGenomes-Gn:BSU14430" /db_xref="EnsemblGenomes-Tr:CAB13316" /db_xref="GOA:O31716" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG13270" /db_xref="UniProtKB/Swiss-Prot:O31716" /translation="MIAVNNVSLRFADRKLFEDVNIKFTPGNCYGLIGANGAGKSTFL KVLSGEIEPQTGDVHMSPGERLAVLKQNHFEYEEYEVLKVVIMGHKRLYEVMQEKDAI YMKPDFSDEDGIRAAELEGEFAELNGWEAESEAAILLKGLGISEDLHTKKMADLGGSE KVKVLLAQALFGKPDVLLLDEPTNHLDLQAIQWLEEFLINFENTVIVVSHDRHFLNKV CTHIADLDFNKIQIYVGNYDFWYESSQLALKLSQEANKKKEEQIKQLQEFVARFSANA SKSKQATSRKKLLEKITLDDIKPSSRRYPYVNFTPEREIGNDVLRVEGLTKTIDGVKV LDNVSFIMNREDKIAFTGRNELAVTTLFKIISGEMEADSGTFKWGVTTSQAYFPKDNS EYFEGSDLNLVDWLRQYSPHDQSESFLRGFLGRMLFSGEEVHKKANVLSGGEKVRCML SKAMLSGANILILDEPTNHLDLESITALNNGLISFKGAMLFTSHDHQFVQTIANRIIE ITPNGIVDKQMSYDEFLENADVQKKLTELYAE*" /label="ykpA CDS" gene 1393568..1395190 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /label="ykpA gene" downshifts 1395178 /Source="Nicolas_upshifts" /id="D805" /incds=0 /nref=45 /ntot=239 /MaxReadThrough="5.13671" /MaxDrop="3.6227" /score="17.6386925" /energy="-7.6" /TU="U1190" /idTUdmin="U1190" /TUdmin="-993" /isTUend="FALSE" /label="downshifts" CDS 1395247..1396158 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 15966718, 17229734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate reductase" /protein_id="NP_389327.1" /db_xref="EnsemblGenomes-Gn:BSU14440" /db_xref="EnsemblGenomes-Tr:CAB13317" /db_xref="GOA:O31717" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13271" /db_xref="UniProtKB/Swiss-Prot:O31717" /translation="MKFLVVGAGGVGGYIGGRLSEKGNDVTFLVRQKRAEQLKKTGLV IHSEKGNVSFQPELISAGETGQFDVVIIASKAYSLGQVIEDVKPFIHQESVIIPFLNG YRHYEQLFAAFSKEQVLGGLCFIESALDNKGEIHHTSASHRFVFGEWNGERTERIRAL EEAFSGVKAEVIISGHIEKDIWKKYLFIAAQAGITTLFQRPLGPILATEAGRHTAQTL IGEICTVLRKEGVPADPALEEESFRTMTSMSYHMKSSMLRDMENGQTTEGDHLHGFLI EKAKRLSLAAPVLETVYANLQMYEAEK*" /label="panE CDS" gene 1395247..1396158 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /label="panE gene" downshifts 1396163 /Source="Nicolas_upshifts" /id="D806" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="2.04919" /MaxDrop="4.55439" /score="11.4959806" /energy="-9.6" /TU="NA" /idTUdmin="U1190" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(1396192..1397424) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /EC_number="3.4.11.24" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9362117, 16088219, 22808738" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9362117, 16088219, 22808738; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase" /protein_id="NP_389328.1" /db_xref="EnsemblGenomes-Gn:BSU14450" /db_xref="EnsemblGenomes-Tr:CAB13318" /db_xref="GOA:P39762" /db_xref="InterPro:IPR000787" /db_xref="InterPro:IPR035097" /db_xref="SubtiList:BG10986" /db_xref="UniProtKB/Swiss-Prot:P39762" /translation="MDSFSQKLNTYAQLAVEVGVNVQKGQYVVVNASTDVRDFVRLIV KHAYEKGAKNVTVNWQDDEVAKLKYELAPFEAFEEYPEWEAKGREELAKNGAAFISVV SSNPDLLKGIDSKRIAAFQKAAGKALHTYRQYIQSDKVSWTVVGAASAGWAHKVFPGK SEEEAIHLLWEEIFKATRVNEDNPVQAWINHDQNLHEKVDHLNERHYAALHYQAEGTD LTIKLPRKHVWAGAGSVNESGHEFMANMPTEEVFTLPQKDGVDGVVSSTKPLSYGGNI IENFTLTFENGRIVDIKAEKGEDILKELVETDEGSHYLGEVALVPYDSPISQSNILFY NTLFDENASNHLAIGSAYAFNIEGGKQMSREELVKEGLNESITHVDFMIGSKDMNIDG ITADGKREPIFRNGNWAF*" /label="ampS CDS" gene complement(1396192..1397424) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /label="ampS gene" downshifts complement(1396203) /Source="Nicolas_upshifts" /id="D807" /incds=0 /nref=215 /ntot=254 /MaxReadThrough="1.34101" /MaxDrop="5.7635" /score="40.7811053" /energy="-9.6" /TU="NA" /idTUdmin="U1191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1397442..1397461) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1397466) /Source="Nicolas_upshifts" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1397476..1397481) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1397534..1397668) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389329.1" /db_xref="EnsemblGenomes-Gn:BSU14460" /db_xref="EnsemblGenomes-Tr:CAB13319" /db_xref="InterPro:IPR035379" /db_xref="SubtiList:BG11812" /db_xref="UniProtKB/Swiss-Prot:Q45492" /translation="MLRDLGRRVAIAAILSGIILGGMSISLANMPHSPAGGTVKLNHP *" /label="ykpC CDS" gene complement(1397534..1397668) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /label="ykpC gene" downshifts complement(1397545) /Source="Nicolas_upshifts" /id="D808" /incds=0 /nref=51 /ntot=151 /MaxReadThrough="3.10365" /MaxDrop="5.04142" /score="-2.2377884" /energy="-9.1" /TU="U1192" /idTUdmin="U1193" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1397690..1397708) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1397701) /Source="Nicolas_upshifts" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1397703..1397768) /Source="Nicolas_S_feature" /locus_tag="new_1516508_1516573_c" /HighExp="HiTm, C30, Lbstat, MG-0.2, BC, G135, MG 15, MG 10, MG-0.1, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S524" promotor_-35 complement(1397724..1397729) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1397769..1398776) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16950129, 19643765, 19659933, 21091501, 21636651, 26091431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950129, 19643765, 19659933, 21091501, 21636651, 26091431; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_389330.1" /db_xref="EnsemblGenomes-Gn:BSU14470" /db_xref="EnsemblGenomes-Tr:CAB13320" /db_xref="GOA:P39763" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10987" /db_xref="UniProtKB/Swiss-Prot:P39763" /translation="MFQSTEIGIDLGTANILVYSKNKGIILNEPSVVAVDTTTKAVLA IGADAKNMIGKTPGKIVAVRPMKDGVIADYDMTTDLLKHIMKKAAKSIGMSFRKPNVV VCTPSGSTAVERRAISDAVKNCGAKNVHLIEEPVAAAIGADLPVDEPVANVVVDIGGG TTEVAIISFGGVVSCHSIRIGGDQLDEDIVSFVRKKYNLLIGERTAEQVKMEIGHALI EHIPEAMEIRGRDLVTGLPKTIMLQSNEIQDAMRESLLHILEAIRATLEDCPPELSGD IVDRGVILTGGGALLNGIKEWLTEEIVVPVHVAQNPLESVAIGTGRSLEVIDKLQKAI K*" /label="mreBH CDS" gene complement(1397769..1398776) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /label="mreBH gene" upshifts complement(1398822) /Source="Nicolas_upshifts" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1398823..1398831) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1398845..1398853) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1398963..1398972 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-35" upshifts 1398984 /Source="Nicolas_upshifts" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="upshifts" promotor_-10 1398985..1399000 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-10" S_feature 1398987..1399059 /Source="Nicolas_S_feature" /locus_tag="new_1517792_1517864" /HighExp="Lbexp, dia5, LBGexp, dia0, Lbtran, Mt0, Oxctl, Paraq, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S525" CDS 1399060..1399338 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16159768, 17720793, 19767430, 20817675, 20844865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159768, 17720793, 19767430, 20817675, 20844865; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389331.1" /db_xref="EnsemblGenomes-Gn:BSU14480" /db_xref="EnsemblGenomes-Tr:CAB13321" /db_xref="GOA:P39758" /db_xref="InterPro:IPR007159" /db_xref="PDB:2FY9" /db_xref="PDB:2RO3" /db_xref="SubtiList:BG10988" /db_xref="UniProtKB/Swiss-Prot:P39758" /translation="MKSIGVVRKVDELGRIVMPIELRRALDIAIKDSIEFFVDGDKII LKKYKPHGVCLMTGEITSENKEYGNGKITLSPEGAQLLLEEIQAALKE*" /label="abhA CDS" gene 1399060..1399338 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /label="abhA gene" downshifts 1399336 /Source="Nicolas_upshifts" /id="D809" /incds=0 /nref=61 /ntot=238 /MaxReadThrough="4.68201" /MaxDrop="5.62457" /score="7.91393519" /energy="-11" /TU="U1194" /idTUdmin="U1194" /TUdmin="-135" /isTUend="FALSE" /label="downshifts" S_feature complement(1399370..1400999) /Source="Nicolas_S_feature" /locus_tag="new_1518175_1519804_c" /HighExp="S6, S8, S5, LoTm, S4, S7, S3, C30, T5.0H, BT" /AntisenseName="kinC" /AntisenseCor="-0.76370141168998495" /AntisenseRegPval="-51.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S526" S_feature 1399381..1399485 /Source="Nicolas_S_feature" /locus_tag="new_1518186_1518290" /HighExp="Oxctl, Lbexp, LBGexp, H2O2, dia0, Paraq, G180, G150, G135, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S527" downshifts complement(1399393) /Source="Nicolas_upshifts" /id="D810" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.833919999999999" /MaxDrop="3.11258" /score="8.02057524" /energy="-11" /TU="NA" /idTUdmin="U1196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1399467..1399474 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1399486..1399505 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1399487 /Source="Nicolas_upshifts" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="upshifts" CDS 1399528..1400814 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /EC_number="2.7.13.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-responsive histidine kinase regulating cannibalism and biofilm formation" /protein_id="NP_389332.1" /db_xref="EnsemblGenomes-Gn:BSU14490" /db_xref="EnsemblGenomes-Tr:CAB13322" /db_xref="GOA:P39764" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10989" /db_xref="UniProtKB/Swiss-Prot:P39764" /translation="MRKYQARIISIILAMIFIMFWDYLFYFIGKNPINWPVDIVYTAV TLVSVWMLAYYIDEKQQLVKKMKDNEWKYKQLSEEKNRIMDNLQEIVFQTNAKGEITY LNQAWASITGFSISECMGTMYNDYFIKEKHVADHINTQIQNKASSGMFTAKYVTKNGT IFWGEVHYKLYYDRDDQFTGSLGTMSDITERKEAEDELIEINERLARESQKLSITSEL AAGIAHEVRNPLTSVSGFLQIMKTQYPDRKDYFDIIFSEIKRIDLVLSELLLLAKPQA ITFKTHQLNEILKQVTTLLDTNAILSNIVIEKNFKETDGCMINGDENQLKQVFINIIK NGIEAMPKGGVVTISTAKTASHAVISVKDEGNGMPQEKLKQIGKPFYSTKEKGTGLGL PICLRILKEHDGELKIESEAGKGSVFQVVLPLKSDS*" /label="kinC CDS" gene 1399528..1400814 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /label="kinC gene" CDS 1400830..1401663 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /EC_number="2.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28537416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative gamma-glutamylcyclotransferase (bacillithiol degradation)" /protein_id="NP_389333.1" /db_xref="EnsemblGenomes-Gn:BSU14500" /db_xref="EnsemblGenomes-Tr:CAB13323" /db_xref="GOA:P39759" /db_xref="InterPro:IPR009288" /db_xref="InterPro:IPR013024" /db_xref="InterPro:IPR036568" /db_xref="PDB:2QIK" /db_xref="SubtiList:BG10990" /db_xref="UniProtKB/Swiss-Prot:P39759" /translation="MNSLLFVYGTLRKHEKNHHLLAQSACINEQARTKGSLFAAKEGP TVVFNDEDEGYIYGEVYEADELCIHKLDQFFQGYHKQTVFVETDVGIKIALIYFMNKD GCAGFTKISSGDWKEHQMISKSKNPIYYFAYGSCMDNARFQKAGVDHYFQDPVGRAVL KGYTTRFTLKREDGSRADMLEDGGTTEGVLYRIPYSALSYLYKREGVESLTYRPAFVD VEAGGRHYKDCLTFLVLQKEAEIAPPQHYQIEIERGAELYLSPEFTEKLKRHMNSLPK G*" /label="ykqA CDS" gene 1400830..1401663 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /label="ykqA gene" promotor_-10 complement(1400996..1401014) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1401011) /Source="Nicolas_upshifts" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1401030..1401035) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1401726..1402391 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 22720735, 23963175, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 22720735, 23963175, 28420751; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_389334.1" /db_xref="EnsemblGenomes-Gn:BSU14510" /db_xref="EnsemblGenomes-Tr:CAB13324" /db_xref="GOA:P39760" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG10991" /db_xref="UniProtKB/Swiss-Prot:P39760" /translation="MKKEFAVIGLGRFGGSICKALSEEGVEVMAMDIDEDKVNEYAKI ASHAVIGDSTDESVLKNLGLRNFDHVIVAIGENIQASILTTLILKELGVHTITVKAQN DYHEKVLSKIGADHIVHPERDMAKRIAHNIVSNNVLDYLELSEEHSLVEIVANSRLAG NTLLDLDIRAKYGINIVAIKRGKEVIVSPLATEVIHQEDILIVIGSVTDISRFEKRVL HTK*" /label="ktrC CDS" gene 1401726..1402391 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /label="ktrC gene" downshifts 1402375 /Source="Nicolas_upshifts" /id="D811" /incds=0 /nref=191 /ntot=256 /MaxReadThrough="3.15176" /MaxDrop="5.50828" /score="4.60161255" /energy="-8.2" /TU="U1195" /idTUdmin="U1195" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1402482..1402488 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1402503..1402522) /Source="Nicolas_upshift_promotors" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1402503..1402522 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1402515 /Source="Nicolas_upshifts" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1402517) /Source="Nicolas_upshifts" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1402546..1404279 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 8550522, 17183219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 8550522, 17183219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine deaminase" /protein_id="NP_389335.2" /db_xref="EnsemblGenomes-Gn:BSU14520" /db_xref="EnsemblGenomes-Tr:CAB13325" /db_xref="GOA:P39761" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11044" /db_xref="UniProtKB/Swiss-Prot:P39761" /translation="MNKEALVNRLNASAKRQKADIVIKNGKIMDVYNQEWIYEDIAIT DGVIVGLGEYEGENIIDAEGQMIVPGFIDGHVHIESSMVTPIEFAKAVLPHGVTTVVT DPHEIANVSGEKGIEFMLEQARHTPLNIHFMLPSSVPAASFERSGAILKAADLKPFYE EEEVLGLAEVMDYVSVQQAEKDMVQKLLDARVAGKRIDGHLAGLSTDLINIYRTAFVL NDHEVTSKEEALDRIRRGMYVMMREGSVAKNTLNVLPAVNEKNARRFFFCTDDKHVDD LLSEGSVNHQVKMAIQAGLNPFLAYQLGSLNAAECYGLDTKGAIAPGFDADLLFVSDL ENVTVTMTMVKGQTVAEDSKAVYQDHASTAAPDQALLDSVKLAAPLNKQDFHMPIDSE QQINVIQIIPNQLETRLVQVPAPVAREFEPDTELDLLKIAVVERHKGLKETGLGVVKG FGFKSGAIATTISHDSHNIIAVGTNDEDIAAAVNKLQEIGGGLTIIKNGEELHSVPLP IAGLLSDQSAEQVNQSLLTLHDKLSLIGFTGGFNPFLTLSFLALPVIPDIKMTTTGLF DVKSFQHISLQ*" /label="adeC CDS" gene 1402546..1404279 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /label="adeC gene" S_feature complement(1403674..1404278) /Source="Nicolas_S_feature" /locus_tag="new_1522479_1523083_c" /HighExp="Etha, C30, C90, dia15, LBGexp, Cold, dia5, S8, G180, S7" /AntisenseName="adeC" /AntisenseCor="-9.8927927273806792E-3" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S528" downshifts 1404268 /Source="Nicolas_upshifts" /id="D812" /incds=0 /nref=51 /ntot=223 /MaxReadThrough="1.93923" /MaxDrop="6.63088" /score="44.3452043" /energy="-19.5" /TU="NA" /idTUdmin="U1197" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1404313..1405980) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease J1" /protein_id="NP_389336.1" /db_xref="EnsemblGenomes-Gn:BSU14530" /db_xref="EnsemblGenomes-Tr:CAB13326" /db_xref="GOA:Q45493" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001587" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="PDB:3ZQ4" /db_xref="SubtiList:BG11813" /db_xref="UniProtKB/Swiss-Prot:Q45493" /translation="MKFVKNDQTAVFALGGLGEIGKNTYAVQFQDEIVLIDAGIKFPE DELLGIDYVIPDYTYLVKNEDKIKGLFITHGHEDHIGGIPYLLRQVNIPVYGGKLAIG LLRNKLEEHGLLRQTKLNIIGEDDIVKFRKTAVSFFRTTHSIPDSYGIVVKTPPGNIV HTGDFKFDFTPVGEPANLTKMAEIGKEGVLCLLSDSTNSENPEFTMSERRVGESIHDI FRKVDGRIIFATFASNIHRLQQVIEAAVQNGRKVAVFGRSMESAIEIGQTLGYINCPK NTFIEHNEINRMPANKVTILCTGSQGEPMAALSRIANGTHRQISINPGDTVVFSSSPI PGNTISVSRTINQLYRAGAEVIHGPLNDIHTSGHGGQEEQKLMLRLIKPKFFMPIHGE YRMQKMHVKLATDCGIPEENCFIMDNGEVLALKGDEASVAGKIPSGSVYIDGSGIGDI GNIVLRDRRILSEEGLVIVVVSIDMDDFKISAGPDLISRGFVYMRESGDLINDAQELI SNHLQKVMERKTTQWSEIKNEITDTLAPFLYEKTKRRPMILPIIMEV*" /label="rnjA CDS" gene complement(1404313..1405980) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /label="rnjA gene" downshifts complement(1404323) /Source="Nicolas_upshifts" /id="D813" /incds=0 /nref=149 /ntot=269 /MaxReadThrough="4.3738" /MaxDrop="8.12983" /score="37.2074215" /energy="-19.5" /TU="U1199" /idTUdmin="U1200" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1405986..1406195) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /function="9.2: DNA-dependent RNA polymerase" /experiment="publication(s) with functional evidences, PMID:18289874, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18289874, 24187087; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega 1 subunit of RNA polymerase" /protein_id="NP_389337.1" /db_xref="EnsemblGenomes-Gn:BSU14540" /db_xref="EnsemblGenomes-Tr:CAB13327" /db_xref="InterPro:IPR009907" /db_xref="SubtiList:BG13335" /db_xref="UniProtKB/Swiss-Prot:O31718" /translation="MIYKVFYQEKADEVPVREKTDSLYIEGVSERDVRTKLKEKKFNI EFITPVDGAFLEYEQQSENFKVLEL*" /label="rnpZA CDS" gene complement(1405986..1406195) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /label="rnpZA gene" promotor_-10 complement(1406232..1406251) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1406254) /Source="Nicolas_upshifts" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1406256..1406433) /Source="Nicolas_S_feature" /locus_tag="new_1525061_1525238_c" /HighExp="S5, S8, S7, S6, S4, ferm, nit, T5.0H, HiTm, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97062099999999996" /TUshortSig="SigGF" /TUshortPSig="0.828" /TUlongSig="NA" /TUlongPSig="NA" /label="S529" promotor_-35 complement(1406266..1406269) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1406434) /Source="Nicolas_upshifts" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1406436..1406447) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1406461..1406467) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1406506..1406513 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1406527..1406546 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1406543 /Source="Nicolas_upshifts" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1406581..1407354 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389338.1" /db_xref="EnsemblGenomes-Gn:BSU14550" /db_xref="EnsemblGenomes-Tr:CAB13328" /db_xref="GOA:Q45494" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11814" /db_xref="UniProtKB/Swiss-Prot:Q45494" /translation="MDSKLIFFDIDGTIYDHDKNIPESTRKTVAELQRQGHHVFIASG RSPFLVKPILEELGIHSFISYNGQFVVFENQVIYKNPLPENAIRRLLKQADEGKHPVV FMAEDTMKATVADHPHVLEGIGSLKTDYPETDDLFYEGKEIFQLLLFCQDEEEKAYAA FPEFDLVRWHELSTDVLPHGGSKAEGIKKVIERLPFDIGDTYAFGDGLNDLQMIEYVG TGVAMGNAVPELKEIADFVTKPVDEDGIAYAVKELGLLK*" /label="ykrA CDS" gene 1406581..1407354 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /label="ykrA gene" downshifts 1407325 /Source="Nicolas_upshifts" /id="D814" /incds=0 /nref=184 /ntot=249 /MaxReadThrough="2.83896" /MaxDrop="6.20802" /score="28.5519453" /energy="-15.4" /TU="U1201" /idTUdmin="U1201" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1407390..1407944) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11429456, 16207374, 23944997, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16207374, 23944997, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-cysteine deformylase (promiscuous)" /protein_id="NP_389339.1" /db_xref="EnsemblGenomes-Gn:BSU14560" /db_xref="EnsemblGenomes-Tr:CAB13329" /db_xref="GOA:Q45495" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11815" /db_xref="UniProtKB/Swiss-Prot:Q45495" /translation="MITMENIVRDGHPALRETAEPVELPPTDAEKQQLADMIEFVKNS QNPELAEKYKLRPGVGLAAPQINIKKRMIAVHAEDASGKLYSYALFNPKIVSHSVEKS YLTSGEGCLSVDEAIPGYVPRYARIRVKGTTLEGENIDIRLKGFPAIVFQHEIDHLNG VMFYDHIDKENPFKEPENAIAIER*" /label="defB CDS" gene complement(1407390..1407944) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /label="defB gene" downshifts complement(1407401) /Source="Nicolas_upshifts" /id="D815" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="1.87469" /MaxDrop="5.89844" /score="28.3817715" /energy="-15.4" /TU="NA" /idTUdmin="U1202" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1407966..1407985) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1407976) /Source="Nicolas_upshifts" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1408000..1408007) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1408029 /Source="Nicolas_upshifts" /id="D816" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="0.95601" /MaxDrop="4.18336" /score="0.455865843" /energy="-17.1" /TU="NA" /idTUdmin="U1201" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1408053) /Source="Nicolas_upshifts" /id="D817" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.11854" /MaxDrop="8.20445" /score="-8.94821426" /energy="-15.3" /TU="NA" /idTUdmin="U1204" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(1408054..1408212) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin (toxin I motif)" /protein_id="YP_003097725.1" /db_xref="EnsemblGenomes-Gn:BSU14569" /db_xref="EnsemblGenomes-Tr:CAX52616" /db_xref="GOA:C0H409" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H409" /translation="MYGYGYGGGCCSYGGYGYGGCGYGYGRTFALIVVLFILLIIVGA AYLGGGCC*" /label="ykzV CDS" gene complement(1408054..1408212) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /label="ykzV gene" CDS complement(1408119..1408262) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin" /protein_id="YP_009513955.1" /db_xref="EnsemblGenomes-Gn:BSU14568" /db_xref="EnsemblGenomes-Tr:CCQ48596" /db_xref="UniProtKB/TrEMBL:L8E9Z2" /translation="MPTYKGSGVIKRGGYVICMDMVTAEAAAVMVVTDMVAADMATAA PLR*" /label="putative antitoxin CDS" gene complement(1408119..1408262) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /label="gene" promotor_-35 1408208..1408212 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1408213..1408281) /Source="Nicolas_S_feature" /locus_tag="new_1527018_1527086_c" /HighExp="S8, S7, BT, S6, G/S, B36, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S530" promotor_-10 1408222..1408236 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1408249 /Source="Nicolas_upshifts" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1408265..1408284) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1408294) /Source="Nicolas_upshifts" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1408297..1408306) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1408368..1408375 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1408389..1408408 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1408393 /Source="Nicolas_upshifts" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1408426..1409097 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16684363, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389340.2" /db_xref="EnsemblGenomes-Gn:BSU14570" /db_xref="EnsemblGenomes-Tr:CAB13330" /db_xref="GOA:P21884" /db_xref="InterPro:IPR019454" /db_xref="InterPro:IPR036785" /db_xref="SubtiList:BG10206" /db_xref="UniProtKB/Swiss-Prot:P21884" /translation="MKDAIKRRPGIKIGAFCAMALILTGCMGQDPVDSLHHSLEKAAE SEKPFQEEQNTLKELEAKENQLYDSVMKLNMDDYKKIVALSNKALENVSKREEHLKLE NDSMKKSETEFEEAKTSAEHIKEKDIKEKADAAANHMEKRYTSYGTMYKEYKKALELN KKLYMQLKDKDLTRDDLDQQIDKVNASYEKILKYSGEFNEQTEKYNKAREDLYDAAGY RVKKS*" /label="ykyA CDS" gene 1408426..1409097 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /label="ykyA gene" promotor_-35 1408765..1408774 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1408787..1408805 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1408799 /Source="Nicolas_upshifts" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1409044 /Source="Nicolas_upshifts" /id="D818" /incds=0 /nref=96 /ntot=244 /MaxReadThrough="3.9299" /MaxDrop="6.03956" /score="20.6110953" /energy="-9.9" /TU="U1205" /idTUdmin="U1206" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 1409272..1409277 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1409294..1409313 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1409295..1409520 /Source="Nicolas_S_feature" /locus_tag="new_1528100_1528325" /HighExp="nit, MG-0.1, Diami, MG-0.2, ferm, dia5, Lbexp, dia0, Paraq, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S531" upshifts 1409295 /Source="Nicolas_upshifts" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1409299..1409318) /Source="Nicolas_upshift_promotors" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1409315) /Source="Nicolas_upshifts" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1409419..1409427) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1409425) /Source="Nicolas_upshifts" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1409441..1409449) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1409521..1410636 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /EC_number="1.2.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 alpha subunit)" /protein_id="NP_389341.1" /db_xref="EnsemblGenomes-Gn:BSU14580" /db_xref="EnsemblGenomes-Tr:CAB13331" /db_xref="GOA:P21881" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR017596" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10207" /db_xref="UniProtKB/Swiss-Prot:P21881" /translation="MAAKTKKAIVDSKKQFDAIKKQFETFQILNEKGEVVNEAAMPDL TDDQLKELMRRMVFTRVLDQRSISLNRQGRLGFYAPTAGQEASQIATHFALEKEDFVL PGYRDVPQLIWHGLPLYQAFLFSRGHFRGNQMPDDVNALSPQIIIGAQYIQTAGVALG LKKRGKKAVAITYTGDGGASQGDFYEGINFAGAYKAPAIFVVQNNRYAISTPVEKQSA AETIAQKAVAAGIVGVQVDGMDPLAVYAATAEARERAINGEGPTLIETLTFRYGPHTM AGDDPTKYRTKEIENEWEQKDPLVRFRAFLENKGLWSEEEEAKVIEDAKEEIKQAIKK ADAEPKQKVTDLMKIMYEKMPHNLEEQFEIYTQKESK*" /label="pdhA CDS" gene 1409521..1410636 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /label="pdhA gene" CDS 1410640..1411617 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /EC_number="1.2.4.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 9891797, 10735853, 11976308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 9891797, 10735853, 11976308; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 beta subunit)" /protein_id="NP_389342.1" /db_xref="EnsemblGenomes-Gn:BSU14590" /db_xref="EnsemblGenomes-Tr:CAB13332" /db_xref="GOA:P21882" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10208" /db_xref="UniProtKB/Swiss-Prot:P21882" /translation="MAQMTMIQAITDALRTELKNDENVLVFGEDVGVNGGVFRATEGL QKEFGEDRVFDTPLAESGIGGLALGLGLNGFRPVMEIQFFGFVYEVMDSVSGQMARMR YRSGGRWTSPVTIRSPFGGGVHTPELHADSLEGLVAQQPGIKVVIPSTPYDAKGLLIS AIRDNDPVVFLEHMKLYRSFRQEVPEEEYTIELGKADVKREGTDLSIITYGAMVHESL KAADELEKDGISAEVVDLRTVSPLDIDTIIASVEKTGRAIVVQEAQKQAGIAANVVAE INDRAILSLEAPVLRVAAPDTVFPFSQAESVWLPNHKDVLETARKVLEF*" /label="pdhB CDS" gene 1410640..1411617 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /label="pdhB gene" S_feature 1411618..1411731 /Source="Nicolas_S_feature" /locus_tag="new_1530423_1530536" /HighExp="G150, LBGexp, MG-0.1, G180, C30, Diami, Oxctl, G135, ferm, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S532" promotor_-10 complement(1411652..1411671) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1411669) /Source="Nicolas_upshifts" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1411686..1411689) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1411732..1413060 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /EC_number="2.3.1.12" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (dihydrolipoamide acetyltransferase E2 subunit)" /protein_id="NP_389343.1" /db_xref="EnsemblGenomes-Gn:BSU14600" /db_xref="EnsemblGenomes-Tr:CAB13333" /db_xref="GOA:P21883" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10209" /db_xref="UniProtKB/Swiss-Prot:P21883" /translation="MAFEFKLPDIGEGIHEGEIVKWFVKPNDEVDEDDVLAEVQNDKA VVEIPSPVKGKVLELKVEEGTVATVGQTIITFDAPGYEDLQFKGSDESDDAKTEAQVQ STAEAGQDVAKEEQAQEPAKATGAGQQDQAEVDPNKRVIAMPSVRKYAREKGVDIRKV TGSGNNGRVVKEDIDSFVNGGAQEAAPQETAAPQETAAKPAAAPAPEGEFPETREKMS GIRKAIAKAMVNSKHTAPHVTLMDEVDVTNLVAHRKQFKQVAADQGIKLTYLPYVVKA LTSALKKFPVLNTSIDDKTDEVIQKHYFNIGIAADTEKGLLVPVVKNADRKSVFEISD EINGLATKAREGKLAPAEMKGASCTITNIGSAGGQWFTPVINHPEVAILGIGRIAEKA IVRDGEIVAAPVLALSLSFDHRMIDGATAQNALNHIKRLLNDPQLILMEA*" /label="pdhC CDS" gene 1411732..1413060 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /label="pdhC gene" promotor_-35 1411876..1411883 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1411898..1411917 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1411901 /Source="Nicolas_upshifts" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="upshifts" CDS 1413065..1414477 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /EC_number="1.8.1.4" /EC_number="1.2.1.25" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 6815422, 9352926, 9588797, 12682299, 21856851" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 6815422, 9352926, 9588797, 12682299, 21856851; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="dihydrolipoamide dehydrogenase E3 subunit of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes" /protein_id="NP_389344.1" /db_xref="EnsemblGenomes-Gn:BSU14610" /db_xref="EnsemblGenomes-Tr:CAB13334" /db_xref="GOA:P21880" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10210" /db_xref="UniProtKB/Swiss-Prot:P21880" /translation="MVVGDFPIETDTLVIGAGPGGYVAAIRAAQLGQKVTVVEKATLG GVCLNVGCIPSKALINAGHRYENAKHSDDMGITAENVTVDFTKVQEWKASVVNKLTGG VAGLLKGNKVDVVKGEAYFVDSNSVRVMDENSAQTYTFKNAIIATGSRPIELPNFKYS ERVLNSTGALALKEIPKKLVVIGGGYIGTELGTAYANFGTELVILEGGDEILPGFEKQ MSSLVTRRLKKKGNVEIHTNAMAKGVEERPDGVTVTFEVKGEEKTVDADYVLITVGRR PNTDELGLEQVGIEMTDRGIVKTDKQCRTNVPNIYAIGDIIEGPPLAHKASYEGKIAA EAIAGEPAEIDYLGIPAVVFSEPELASVGYTEAQAKEEGLDIVAAKFPFAANGRALSL NETDGFMKLITRKEDGLVIGAQIAGASASDMISELSLAIEGGMTAEDIAMTIHAHPTL GEITMEAAEVAIGSPIHIVK*" /label="pdhD CDS" gene 1413065..1414477 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /label="pdhD gene" downshifts 1414474 /Source="Nicolas_upshifts" /id="D819" /incds=0 /nref=241 /ntot=268 /MaxReadThrough="1.82289" /MaxDrop="9.27853" /score="33.2247807" /energy="-12.1" /TU="NA" /idTUdmin="U1207" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1414522..1414896) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1936936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1936936; Product type s : structure" /codon_start=1 /transl_table=11 /product="small peptidoglycan-associated lipoprotein" /protein_id="NP_389345.1" /db_xref="EnsemblGenomes-Gn:BSU14620" /db_xref="EnsemblGenomes-Tr:CAB13335" /db_xref="GOA:P39910" /db_xref="SubtiList:BG10211" /db_xref="UniProtKB/Swiss-Prot:P39910" /translation="MRYRAVFPMLIIVFALSGCTLSTINPMKKSRIDNIHHTQILFFS DENQIDQEAPYYDALLDLEKDYPEQIDKMKVYDKKEGWEDEIETVPTLMVVDQRHVVV KIEGCVKKKEDIIKPLQHVLSK*" /label="slp CDS" gene complement(1414522..1414896) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /label="slp gene" downshifts complement(1414570) /Source="Nicolas_upshifts" /id="D820" /incds=0 /nref=26 /ntot=132 /MaxReadThrough="1.54024" /MaxDrop="3.69756" /score="4.23955997" /energy="-12.1" /TU="NA" /idTUdmin="U1212" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(1414927..1414946) /Source="Nicolas_upshift_promotors" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1414937) /Source="Nicolas_upshifts" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1415100..1415105 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-35" promotor_-10 1415121..1415139 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-10" upshifts 1415131 /Source="Nicolas_upshifts" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="upshifts" S_feature 1415135..1415244 /Source="Nicolas_S_feature" /locus_tag="new_1533940_1534049" /HighExp="S4, S5, S7, S6, S8, S3, BT, G/S, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S533" downshifts complement(1415167) /Source="Nicolas_upshifts" /id="D821" /incds=0 /nref=4 /ntot=18 /MaxReadThrough="1.96608" /MaxDrop="3.4036" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1415228..1415235 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1415246 /Source="Nicolas_upshifts" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1415250..1415269 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1415265..1415475 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /product="small regulatory RNA and messenger RNA (argininemetabolism)" /experiment="publication(s) with functional evidences, PMID:16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348; Product type n: RNA" /function="16.3: Control" /label="srrA RNA" gene 1415265..1415475 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /label="srrA gene" CDS 1415315..1415434 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16164558, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 20444087, 27449348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of GapA synthesis" /protein_id="YP_003097726.1" /db_xref="EnsemblGenomes-Gn:BSU14629" /db_xref="EnsemblGenomes-Tr:CAX52617" /db_xref="InterPro:IPR025236" /db_xref="UniProtKB/Swiss-Prot:C0H410" /translation="MGTIVCQDCNEAIHYFEDEKVTTLYGTCCGQCQCPVDEE*" /label="rgpA CDS" gene 1415315..1415434 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /label="rgpA gene" downshifts complement(1415321) /Source="Nicolas_upshifts" /id="D822" /incds=0 /nref=6 /ntot=35 /MaxReadThrough="3.43398" /MaxDrop="4.36472" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts 1415421 /Source="Nicolas_upshifts" /id="D823" /incds=0 /nref=59 /ntot=171 /MaxReadThrough="5.69396" /MaxDrop="7.24152" /score="51.2534618" /energy="-16.8" /TU="U1214" /idTUdmin="U1213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1415466..1417069 /Source="Nicolas_S_feature" /locus_tag="new_1534271_1535874" /HighExp="M9-stat, M0t90, B60, M40t90, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T0.30H" /AntisenseName="speA" /AntisenseCor="-0.33575411980382203" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.998" /label="S534" CDS complement(1415474..1416946) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /EC_number="4.1.1.19" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 19114526, 19255484, 20876533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 19114526, 19255484, 20876533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine decarboxylase" /protein_id="NP_389346.1" /db_xref="EnsemblGenomes-Gn:BSU14630" /db_xref="EnsemblGenomes-Tr:CAB13336" /db_xref="GOA:P21885" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10212" /db_xref="UniProtKB/Swiss-Prot:P21885" /translation="MSQHETPLYTGLKKHASRQPVQFHIPGHKKGAGMDPEFRQFIGE NALSIDLINIEPLDDLHAPKGIIKQAQDLAAEAFGADHTFFSVQGTSGAIMTMVMAVC GPGDKIIIPRNVHKSIMTAIVFSGAVPIFIHPEIDNELGISHGITLESAKRALTEHPD AKGLLVINPTYFGVAADLKSIVELAHSFDVPVLVDEAHGVHIHFHDELPLSAMQAGAD IAATSVHKLGGSLTQSSILNMREGLVSKDRVQSILSMLTTTSTSYLLLASLDVARKRL ATEGRQLAEETLKLANQTRDRLNQIEGIYCVGSEILGSKAAYSYDPTKLIISVKSLGL TGHDVEKWLRESFNIEVELSDLYNILCIFTPGDSQNDADRLVEALTEIAQQMSEQDVT HQQTEVLLPEIPLLAMTPRDAFYANTEVIPLKEASGRIIAEFVMVYPPGIPIFIPGEI ITEENISYIFKNLDAGLPVQGPEDSTLHMIRVIKEQKAIQ*" /label="speA CDS" gene complement(1415474..1416946) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /label="speA gene" downshifts complement(1415492) /Source="Nicolas_upshifts" /id="D824" /incds=0 /nref=62 /ntot=198 /MaxReadThrough="3.88498" /MaxDrop="6.76978" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(1416947..1417042) /Source="Nicolas_S_feature" /locus_tag="new_1535752_1535847_c" /HighExp="Paraq, G180, LBGexp, Oxctl, G150, G135, C30, H2O2, BMM, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S535" promotor_-10 complement(1417025..1417044) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1417042) /Source="Nicolas_upshifts" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1417049..1417052 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1417059..1417066) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1417067..1417086 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1417071 /Source="Nicolas_upshifts" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="upshifts" CDS 1417131..1417397 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389347.1" /db_xref="EnsemblGenomes-Gn:BSU14640" /db_xref="EnsemblGenomes-Tr:CAB13337" /db_xref="InterPro:IPR007920" /db_xref="InterPro:IPR023324" /db_xref="SubtiList:BG11816" /db_xref="UniProtKB/Swiss-Prot:Q45497" /translation="MEYQYPMNEDWTTEEAVDVIAFFQQVELAYEKGADREELLKAYR RFKEIVPGKAEEKKLCGEFEEQSTYSPYRTVKQARESDHAKIKM*" /label="yktA CDS" gene 1417131..1417397 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" /label="yktA gene" downshifts 1417379 /Source="Nicolas_upshifts" /id="D825" /incds=0 /nref=105 /ntot=250 /MaxReadThrough="2.62284" /MaxDrop="5.09814" /score="40.0811023" /energy="-16.1" /TU="NA" /idTUdmin="U1214" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1417430..1418068) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25643072" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389348.1" /db_xref="EnsemblGenomes-Gn:BSU14650" /db_xref="EnsemblGenomes-Tr:CAB13338" /db_xref="InterPro:IPR009403" /db_xref="PDB:2A8E" /db_xref="SubtiList:BG11817" /db_xref="UniProtKB/Swiss-Prot:Q45498" /translation="MTQMRFTEEDFNTFTIEGLDARMEVLKETVRPKLTALGEHFAPT LSALTGDEMFPHVAKHARRSVNPPADSWVAFANSKRGYKKLPHFQIGLWESHVFVWFA IIYESPIKEEYGKLLEVNQETITKNIPDSFVWSADHTKPGVHKQSEMDKEQLKTLFER LQTVKKAELLCGIQLQKEEVLNMNNQEFLQRIDDAFKQLAFLYRLTQKVTQA*" /label="yktB CDS" gene complement(1417430..1418068) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" /label="yktB gene" downshifts complement(1417455) /Source="Nicolas_upshifts" /id="D826" /incds=0 /nref=184 /ntot=257 /MaxReadThrough="2.62959" /MaxDrop="6.54203" /score="26.7765804" /energy="-14.5" /TU="U1217" /idTUdmin="U1217" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1418089..1418108) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1418113) /Source="Nicolas_upshifts" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1418123..1418127) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1418138..1418144 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1418159..1418177 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1418160 /Source="Nicolas_upshifts" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1418198..1418207 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1418220..1418239 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1418224..1418307 /Source="Nicolas_S_feature" /locus_tag="new_1537029_1537112" /HighExp="Etha, S7, M9-stat, S6, S8, BT, Gly, Salt, B60, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S536" upshifts 1418224 /Source="Nicolas_upshifts" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="upshifts" CDS 1418308..1418496 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved general stress protein" /protein_id="NP_389349.1" /db_xref="EnsemblGenomes-Gn:BSU14660" /db_xref="EnsemblGenomes-Tr:CAB13339" /db_xref="SubtiList:BG13337" /db_xref="UniProtKB/Swiss-Prot:O31719" /translation="MRQVVKEGFKEEKNNRVAVWRLEVDYELATLYEAMQKENEEQIE QSKNKLERLRKEWIRLNG*" /label="ykzI CDS" gene 1418308..1418496 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" /label="ykzI gene" downshifts complement(1418313) /Source="Nicolas_upshifts" /id="D827" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="1.50398" /MaxDrop="3.97385" /score="26.7765804" /energy="-14.5" /TU="NA" /idTUdmin="U1220" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1418489 /Source="Nicolas_upshifts" /id="D828" /incds=0 /nref=13 /ntot=45 /MaxReadThrough="7.33866" /MaxDrop="6.12123" /score="-8.73613673" /energy="-8.1" /TU="U1218,U1219" /idTUdmin="U1219" /TUdmin="-628" /isTUend="FALSE" /label="downshifts" upshifts complement(1418511) /Source="Nicolas_upshifts" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1418519..1418522) /Source="Nicolas_upshift_promotors" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1418566..1418569 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1418586..1418605 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1418589 /Source="Nicolas_upshifts" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="upshifts" CDS 1418636..1419433 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" /EC_number="3.1.3.-" /EC_number="3.1.3.25" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914086, 16682444, 22333191, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914086, 16682444, 22333191, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inositol monophosphatase / 5' nucleotidase (purine nucleoside monophosphate)" /protein_id="NP_389350.1" /db_xref="EnsemblGenomes-Gn:BSU14670" /db_xref="EnsemblGenomes-Tr:CAB13340" /db_xref="GOA:Q45499" /db_xref="InterPro:IPR000760" /db_xref="InterPro:IPR020550" /db_xref="InterPro:IPR020583" /db_xref="InterPro:IPR033942" /db_xref="SubtiList:BG11818" /db_xref="UniProtKB/Swiss-Prot:Q45499" /translation="MTNWTEIDEIAKKWIREAGARITQSMHESLTIETKSNPNDLVTN IDKETEKFFIDRIQETFPGHRILGEEGQGDKIHSLEGVVWIIDPIDGTMNFVHQQRNF AISIGIFENGEGKIGLIYDVVHDELYHAFSGRGAYMNETKLAPLKETVIEEAILAINA TWVTENRRIDQSVLAPLVKRVRGTRSYGSAALELANVAAGRIDAYITMRLAPWDYAAG CVLLNEVGGTYTTIEGEPFTFLENHSVLAGNPSIHKTIFEEYLHARK*" /label="suhB CDS" gene 1418636..1419433 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" /label="suhB gene" CDS 1419459..1419887 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389351.1" /db_xref="EnsemblGenomes-Gn:BSU14680" /db_xref="EnsemblGenomes-Tr:CAB13341" /db_xref="GOA:O31720" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13331" /db_xref="UniProtKB/Swiss-Prot:O31720" /translation="MLEKLAEAHPVWKEEEFGDKDAEDYIISYSMYNGSWLVWEKDGM PVAVSYHLEWSPSNGKPWLGTVLIDPAEEKKGHAKMIIEQISKLLRAKHKAMFAGVPI ERREWILFLSQCGFEQLKTEKDEKGKSFMILVKPLAEAAV*" /label="ykzC CDS" gene 1419459..1419887 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" /label="ykzC gene" downshifts 1419844 /Source="Nicolas_upshifts" /id="D829" /incds=0 /nref=80 /ntot=232 /MaxReadThrough="4.50069" /MaxDrop="4.3098" /score="-9.99315734" /energy="-11.8" /TU="U1218,U1221" /idTUdmin="U1218" /TUdmin="-153" /isTUend="FALSE" /label="downshifts" S_feature 1419888..1420841 /Source="Nicolas_S_feature" /locus_tag="new_1538693_1539646" /HighExp="H2O2, dia15, Diami, Paraq, G180, G135, G150, dia5, Heat, LBGexp" /AntisenseName="yktD" /AntisenseCor="-1.5120906229522399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="0.117724" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S537" downshifts complement(1419963) /Source="Nicolas_upshifts" /id="D830" /incds=0 /nref=4 /ntot=85 /MaxReadThrough="0.88821" /MaxDrop="3.44773" /score="19.9363134" /energy="-12.8" /TU="NA" /idTUdmin="U1222" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1419965..1420879) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_389352.1" /db_xref="EnsemblGenomes-Gn:BSU14690" /db_xref="EnsemblGenomes-Tr:CAB13342" /db_xref="GOA:Q45500" /db_xref="InterPro:IPR007213" /db_xref="InterPro:IPR011610" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11819" /db_xref="UniProtKB/Swiss-Prot:Q45500" /translation="MRKNESSLTSLISAFARAYHSRYDTPLIFDDFIAKDLINEKEFI DISKNMIQEISFFNKEIAERLQNDPEKILKWVAQIQLSPTPLARASYCEKVLHNELIL GAKQYVILGAGLDTFCFRHPELENSLQVFEVDHPATQQLKKNKLKDANLTIPGHLHFV PMDFTKTFSYDPLLDEGFKNTKTFFSLLGVSYYVTREENASLISNLFSHVPPGSSIVF DYADETLFTAKGTSNRVEHMVKMAAASGEPMKSCFTYQEIEHLLESSGLLIYEHLSPD DINDLFFSNRKDNLSAFETIHYIHAVKK*" /label="yktD CDS" gene complement(1419965..1420879) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" /label="yktD gene" promotor_-10 complement(1420945..1420964) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1420953) /Source="Nicolas_upshifts" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1420979..1420986) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1421231..1422796) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" /EC_number="3.4.24.28" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2128597, 6090407, 8436952, 15205417, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2128597, 6090407, 8436952, 15205417, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral metalloprotease" /protein_id="NP_389353.1" /db_xref="EnsemblGenomes-Gn:BSU14700" /db_xref="EnsemblGenomes-Tr:CAB13343" /db_xref="GOA:P68736" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10448" /db_xref="UniProtKB/Swiss-Prot:P68736" /translation="MGLGKKLSVAVAASFMSLSISLPGVQAAEGHQLKENQTNFLSKN AIAQSELSAPNDKAVKQFLKKNSNIFKGDPSKRLKLVESTTDALGYKHFRYAPVVNGV PIKDSQVIVHVDKSDNVYAVNGELHNQSAAKTDNSQKVSSEKALALAFKAIGKSPDAV SNGAAKNSNKAELKAIETKDGSYRLAYDVTIRYVEPEPANWEVLVDAETGSILKQQNK VEHAAATGSGTTLKGATVPLNISYEGGKYVLRDLSKPTGTQIITYDLQNRQSRLPGTL VSSTTKTFTSSSQRAAVDAHYNLGKVYDYFYSNFKRNSYDNKGSKIVSSVHYGTQYNN AAWTGDQMIYGDGDGSFFSPLSGSLDVTAHEMTHGVTQETANLIYENQPGALNESFSD VFGYFNDTEDWDIGEDITVSQPALRSLSNPTKYNQPDNYANYRNLPNTDEGDYGGVHT NSGIPNKAAYNTITKLGVSKSQQIYYRALTTYLTPSSTFKDAKAALIQSARDLYGSTD AAKVEAAWNAVGL*" /label="nprE CDS" gene complement(1421231..1422796) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" /label="nprE gene" promotor_-10 complement(1422831..1422850) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1422842) /Source="Nicolas_upshifts" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1422864..1422871) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1423081..1425021 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16501307" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389354.1" /db_xref="EnsemblGenomes-Gn:BSU14710" /db_xref="EnsemblGenomes-Tr:CAB13344" /db_xref="GOA:O07625" /db_xref="SubtiList:BG13338" /db_xref="UniProtKB/Swiss-Prot:O07625" /translation="MLFVLELFSHYVLHFERYFILSRQSTLLIQWSIVVLAGLYLLVH HPKINRQRTMFLAGVILRIVLLAGVSVELIHQVQSTNFTSAYLREDGKELLPLLHFLL YGYVLLTAFHYMLMPRDHGGKGKFYTFDLAVVSLPIVQMIFSFFSYWKEYPDGMEPIA FVFLFFIITLPIALNVVFFKLYWRTDKILLGLFYTLIIGLLVLLLAPYPNQISKDYGA VMPYTIYLAMAGFLMSYHLFQKSGKVYVRVNKWVTMAVMVFFVLLLNPIYNIGTAAFA VSKPANVHDSFNFVGEHISSEKAEQILKSFFPTDETLYLHDTNMDVHYFYSFESKGYK AEVDEVSQLIRNYEYLQKAHGKKLTNQEYKRKSIAFLERHGRVLHKDHIETKVSQEDG QTVVRIYLKNQLHKKDHADDGAVFYWEKETLMGFSEDPSIYQLDSLLHVHITEQDIHD KVEQMFTALNISKQPYQITDIESDSLLGSMVRVETKVGIVLEFEGESGCLHSLSLPMK KNISMANSRLQHQILSIFDARGSEKKKKSSQGDMVMYTDSSKTYEFVEAQGQLNVYVY SDTPDQSFPYTYRNGTLAYEKVASLYQDVIYKKRMRPIIVQRGDERHYAWLIIIQPFG SNRHDAYVVDGETQEVKSLYES*" /label="ylaA CDS" gene 1423081..1425021 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /label="ylaA gene" CDS 1425011..1425280 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 16501307" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389355.1" /db_xref="EnsemblGenomes-Gn:BSU14720" /db_xref="EnsemblGenomes-Tr:CAB13345" /db_xref="GOA:O07626" /db_xref="SubtiList:BG13339" /db_xref="UniProtKB/Swiss-Prot:O07626" /translation="MNHKEKESVFVDLYDLYKEGELEDESMEWMKQHESLFQKNAEDL KSKTCLKRSPGAEEESQIRYMKVYLSSMYICFILLAIWMTVWFYF*" /label="ylaB CDS" gene 1425011..1425280 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /label="ylaB gene" promotor_-35 1425246..1425250 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1425264..1425283 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1425277 /Source="Nicolas_upshifts" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1425280..1425801 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF-type sigma factor" /protein_id="NP_389356.1" /db_xref="EnsemblGenomes-Gn:BSU14730" /db_xref="EnsemblGenomes-Tr:CAB13346" /db_xref="GOA:O07627" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13340" /db_xref="UniProtKB/Swiss-Prot:O07627" /translation="MKHRDSIEDLYRQYYQEILNYLFRRTHHLETAKDLAQDTFVKAL NGLASFRGHSSIRTWLYTIAHHTFINWYRRDVKYQFTEISKNEGLTQTTYDQPEQYLS RTVKSETLRQELLKLKDQHQSVLILREFQELSYEEIAEILGWSLSKVNTTLHRARLEL KKNMTKSREEERI*" /label="sigP CDS" gene 1425280..1425801 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /label="sigP gene" CDS 1425798..1426091 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-SigP(YlaC) sigma factor" /protein_id="NP_389357.1" /db_xref="EnsemblGenomes-Gn:BSU14740" /db_xref="EnsemblGenomes-Tr:CAB13347" /db_xref="GOA:O07628" /db_xref="InterPro:IPR027383" /db_xref="SubtiList:BG13341" /db_xref="UniProtKB/Swiss-Prot:O07628" /translation="MTCFLVRDLLPLYLEGDCKRETEHVIEEHLKMCSSCRDMYDTMA EPFELESEQAVEEAYLPEEELRFKQRYYGLLIMKAACWFGAAVAMMLIIKLLI*" /label="sigQ CDS" gene 1425798..1426091 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /label="sigQ gene" CDS complement(1426131..1426742) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389358.1" /db_xref="EnsemblGenomes-Gn:BSU14750" /db_xref="EnsemblGenomes-Tr:CAB13348" /db_xref="SubtiList:BG13342" /db_xref="UniProtKB/Swiss-Prot:O07629" /translation="MKKTFVKKAMLTTAAMTSAALLTFGPDAASAKTPVDNTAVQLQH QASTNEDLNTFIDILNQCIYEQDGVYYFDSEKAVELGMTKEEAQVIATLWESTSEFFS IVSQCVYLEDGNYKFDTEKAVELGFTEKEALALEQFFSAVSLKIHILQAAIVLQDDVY SYDKDAALQAGATPLQADVYEKLFSALSQEQLAAIYDMIHPQA*" /label="ylaE CDS" gene complement(1426131..1426742) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /label="ylaE gene" downshifts complement(1426145) /Source="Nicolas_upshifts" /id="D831" /incds=0 /nref=44 /ntot=184 /MaxReadThrough="1.37453" /MaxDrop="4.23106" /score="20.8244305" /energy="-11.7" /TU="NA" /idTUdmin="U1225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1426774..1426793) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1426783) /Source="Nicolas_upshifts" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1426808..1426811) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1426998) /Source="Nicolas_upshifts" /id="D832" /incds=0 /nref=18 /ntot=138 /MaxReadThrough="2.72081" /MaxDrop="5.25382" /score="5.78870736" /energy="-8.3" /TU="NA" /idTUdmin="U1226" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1427015..1427203) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389359.1" /db_xref="EnsemblGenomes-Gn:BSU14760" /db_xref="EnsemblGenomes-Tr:CAB13349" /db_xref="GOA:O07630" /db_xref="InterPro:IPR035211" /db_xref="SubtiList:BG13343" /db_xref="UniProtKB/Swiss-Prot:O07630" /translation="MKKMNWLLLLFAFAAVFSIMLIGVFIAEKSPAGIIASIVLVCAV MGGGFTLKKKMREQGLLD*" /label="ylaF CDS" gene complement(1427015..1427203) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /label="ylaF gene" downshifts complement(1427069) /Source="Nicolas_upshifts" /id="D833" /incds=0 /nref=9 /ntot=204 /MaxReadThrough="4.38484" /MaxDrop="3.2214" /score="5.78870736" /energy="-8.3" /TU="U1226" /idTUdmin="U1226" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1427225..1427244) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1427242) /Source="Nicolas_upshifts" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1427257..1427264) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1427270..1427289 /Source="Nicolas_upshift_promotors" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1427277 /Source="Nicolas_upshifts" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="upshifts" CDS 1427316..1429154 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11683274, 12399512, 9642082, 25135187, 26283392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-associated GTPase" /protein_id="NP_389360.1" /db_xref="EnsemblGenomes-Gn:BSU14770" /db_xref="EnsemblGenomes-Tr:CAB13350" /db_xref="GOA:O07631" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006298" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035651" /db_xref="SubtiList:BG13344" /db_xref="UniProtKB/Swiss-Prot:O07631" /translation="MKLRNDLRNIAIIAHVDHGKTTLVDQLLHQAGTFRANEQVAERA MDSNDLERERGITILAKNTAINYKDTRINILDTPGHADFGGEVERIMKMVDGVVLVVD AYEGCMPQTRFVLKKALEQNLNPVVVVNKIDRDFARPEEVIDEVLDLFIELDANEEQL EFPVVYASAINGTASLDPKQQDENMEALYETIIKHVPAPVDNAEEPLQFQVALLDYND YVGRIGIGRVFRGTMKVGQQVSLMKLDGTAKSFRVTKIFGFQGLKRVEIEEAKAGDLV AVSGMEDINVGETVCPVDHQDPLPVLRIDEPTLQMTFVVNNSPFAGREGKYVTARKIE ERLQSQLQTDVSLRVEPTASPDAWVVSGRGELHLSILIENMRREGYELQVSKPEVIIK EIDGVRCEPVERVQIDVPEEHTGSVMESMGARKGEMVDMINNGNGQVRLIFTVPSRGL IGYSTEFLSLTRGFGILNHTFDSYQPMQAGQVGGRRQGVLVSMENGKATSYGIQGIED RGVIFVEPGTEVYEGMIVGEHNRDNDLVVNVSKMKQQTNVRSATKDQTTTIKKARIMS LEESLEYLNEDEYCEVTPESIRLRKKILNKNEREKAAKKKKTAGLS*" /label="bipA CDS" gene 1427316..1429154 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /label="bipA gene" CDS 1429211..1429528 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unkown function" /protein_id="NP_389361.1" /db_xref="EnsemblGenomes-Gn:BSU14780" /db_xref="EnsemblGenomes-Tr:CAB13351" /db_xref="GOA:O07632" /db_xref="InterPro:IPR025620" /db_xref="SubtiList:BG13345" /db_xref="UniProtKB/Swiss-Prot:O07632" /translation="MNDVSERLSFFAALYQVDRQPAAGMWLLYGTIFVLAVIVFKLGF AKRLPVLKSAVVYVFLALGCTVLTFLGVFLPVAEGLVVAALILIIYKIRLYQSKKGQS AKS*" /label="ylaH CDS" gene 1429211..1429528 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /label="ylaH gene" downshifts 1429502 /Source="Nicolas_upshifts" /id="D834" /incds=0 /nref=241 /ntot=297 /MaxReadThrough="2.76511" /MaxDrop="7.50514" /score="29.8701447" /energy="-12.5" /TU="NA" /idTUdmin="U1227" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(1429577) /Source="Nicolas_upshifts" /id="D835" /incds=0 /nref=240 /ntot=265 /MaxReadThrough="0.672690000000001" /MaxDrop="7.03405" /score="10.4340016" /energy="-12.5" /TU="NA" /idTUdmin="U1228" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1429584..1429793) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389362.1" /db_xref="EnsemblGenomes-Gn:BSU14790" /db_xref="EnsemblGenomes-Tr:CAB13352" /db_xref="InterPro:IPR019241" /db_xref="SubtiList:BG13346" /db_xref="UniProtKB/Swiss-Prot:O07633" /translation="MMRVKCSICDKIETIDDDTLIAKRLRNRPIHTYMCQECHDRIAK KTEERLKTGKFTFHPGQQKKEKVKK*" /label="ylaI CDS" gene complement(1429584..1429793) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /label="ylaI gene" misc_feature complement(1429807..1429826) /Source="Nicolas_upshift_promotors" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1429822) /Source="Nicolas_upshifts" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1429876..1430505) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_389363.1" /db_xref="EnsemblGenomes-Gn:BSU14800" /db_xref="EnsemblGenomes-Tr:CAB13353" /db_xref="GOA:O07634" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13347" /db_xref="UniProtKB/Swiss-Prot:O07634" /translation="MRILFIIIQLTLILSACAYQQGKQGQNVEKESTRQQETKPIHVK DTTQETKDNGTRTDIAKHLVSVAEKNPDVKDATAVVLGGYAVVGIDVDDTLDRSKVET IKYSVAQALKNDRYGANAVVIADPDTVSRLREMSREISEGHPVTGILDELAAIVGRVL PEVPNDVIDNEDEPQTKQQNDQLNRKQQQEMEKEQNDQSDHHMKKNNND*" /label="ylaJ CDS" gene complement(1429876..1430505) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /label="ylaJ gene" downshifts complement(1429907) /Source="Nicolas_upshifts" /id="D836" /incds=0 /nref=57 /ntot=112 /MaxReadThrough="1.90936" /MaxDrop="5.8475" /score="3.85709048" /energy="-7.2" /TU="NA" /idTUdmin="U1229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1430407..1430425) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1430413) /Source="Nicolas_upshifts" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1430437..1430445) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1430540..1430551) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1430545) /Source="Nicolas_upshifts" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1430557..1430562 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-35" promotor_-35 complement(1430566..1430572) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1430578..1430596 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-10" upshifts 1430578 /Source="Nicolas_upshifts" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="upshifts" S_feature 1430579..1430659 /Source="Nicolas_S_feature" /locus_tag="new_1549384_1549464" /HighExp="S3, S5, S4, S8, S6, S7, LoTm, T5.0H, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S538" CDS 1430660..1431988 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12762842, 17114254; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phosphate starvation inducible protein" /protein_id="NP_389364.1" /db_xref="EnsemblGenomes-Gn:BSU14810" /db_xref="EnsemblGenomes-Tr:CAB13354" /db_xref="GOA:O07635" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG13348" /db_xref="UniProtKB/Swiss-Prot:O07635" /translation="MSKIYVLDTNVLLQDPNAIFSFEENEVVIPAVVLEEVDSKKRYM DEVGRNARHVSKLIDALRQKGRLHEHVPLDTGGTLRIELNHRSFHQLQEIFIEKTNDN RILAVAKNLSLEEETKENGRPVILVSKDVLVRVKADAIGLLAEDFLNDRVVDNDEMYS GYKDLYISQQLFSSFYGKNQISVNDVKQHAFYPNQFALMKDELGGSSSAVGIADKTGT VLKRLVFDDEHIWGIRPKNVQQTMALELLLREDIPLVTLIGKAGTGKTLLALAAGLLQ TEDLGIYKKLVVARPIVPVGKDIGYLPGEKEEKLKPWMQPIFDNLEFLFNAKKPGELD AILAGIGSIQVEALTYIRGRSIPDQFIIIDEAQNLTRHEVKTLLTRVGEGSKIVLMGD PEQIDHPYLDSLNNGLAYVVERFKGQPISGSVKLLKGERSGLAQLAADLL*" /label="ylaK CDS" gene 1430660..1431988 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /label="ylaK gene" S_feature complement(1431844..1431991) /Source="Nicolas_S_feature" /locus_tag="new_1550649_1550796_c" /HighExp="M40t90, M0t90, dia15, Lbtran, dia5, Etha, Mt0, Gly, LBGtran, LPhT" /AntisenseName="ylaK" /AntisenseCor="-0.66426410013570203" /AntisenseRegPval="-34.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S539" downshifts complement(1431887) /Source="Nicolas_upshifts" /id="D837" /incds=1 /nref=6 /ntot=67 /MaxReadThrough="3.81309" /MaxDrop="3.44499" /score="3.85709048" /energy="-7.2" /TU="U1232" /idTUdmin="U1232" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 1431989..1432579 /Source="Nicolas_S_feature" /locus_tag="new_1550794_1551384" /HighExp="S3, S4, S6, S5, S8, S7, BT, B36, LoTm, T5.0H" /AntisenseName="ylaL" /AntisenseCor="-0.79954210237955903" /AntisenseRegPval="-60.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S540" CDS complement(1431992..1432477) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389365.1" /db_xref="EnsemblGenomes-Gn:BSU14820" /db_xref="EnsemblGenomes-Tr:CAB13355" /db_xref="GOA:O07636" /db_xref="InterPro:IPR020229" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13349" /db_xref="UniProtKB/Swiss-Prot:O07636" /translation="MSVIQVKGNVTYPITIDPSVWIFDDRKFSFDRKGDSQDTYLQSA GDESDLDPERVIREGRIAPPTLKTEKQYEKQKLMNGSFAMRLGTVLKNAEPNSSATQC VFVTSSGKAAVSLETALNSIVHFSEAGKPIQEGGPVHIYFEDPVHHKQPITDVKEIEI I*" /label="ylaL CDS" gene complement(1431992..1432477) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /label="ylaL gene" promotor_-10 complement(1432489..1432508) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1432517) /Source="Nicolas_upshifts" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1432523..1432530) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1432580..1433509 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:18459799" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18459799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine amidohydrolase; glutaminase" /protein_id="NP_389366.1" /db_xref="EnsemblGenomes-Gn:BSU14830" /db_xref="EnsemblGenomes-Tr:CAB13356" /db_xref="GOA:O07637" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="SubtiList:BG13350" /db_xref="UniProtKB/Swiss-Prot:O07637" /translation="MVCQHNDELEALVKKAKKVTDKGEVASYIPALAKADKHDLSVAI YYSNNVCLSAGDVEKTFTLQSISKVLSLALVLMEYGKDKVFSYVGQEPTGDPFNSIIK LETVNPSKPLNPMINAGALVVTSLIRGRTVKERLDYLLSFIRRLTNNQEITYCREVAE SEYSTSMINRAMCYYMKQYGIFEDDVEAVMDLYTKQCAIEMNSLDLAKIGSVFALNGR HPETGEQVISKDVARICKTFMVTCGMYNASGEFAIKVGIPAKSGVSGGIMGISPYDFG IGIFGPALDEKGNSIAGVKLLEIMSEMYRLSIF*" /label="glsB CDS" gene 1432580..1433509 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /label="glsB gene" misc_feature 1433094..1433113 /Source="Nicolas_upshift_promotors" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1433103 /Source="Nicolas_upshifts" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="upshifts" promotor_-35 1433533..1433536 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1433551..1433570 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1433559 /Source="Nicolas_upshifts" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1433607..1433888 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12682299, 16880555, 17005971,17469204" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389367.1" /db_xref="EnsemblGenomes-Gn:BSU14840" /db_xref="EnsemblGenomes-Tr:CAB13357" /db_xref="InterPro:IPR009983" /db_xref="InterPro:IPR036270" /db_xref="SubtiList:BG13351" /db_xref="UniProtKB/Swiss-Prot:O07638" /translation="MASEMIVDHRQKAFELLKVDAEKILKLIRVQMDNLTMPQCPLYE EVLDTQMFGLSREIDFAVRLGLVDEKDGKDLLYTLERELSALHDAFTAK*" /label="ylaN CDS" gene 1433607..1433888 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /label="ylaN gene" downshifts 1433877 /Source="Nicolas_upshifts" /id="D838" /incds=0 /nref=72 /ntot=227 /MaxReadThrough="5.3857" /MaxDrop="6.58793" /score="2.26145837" /energy="-6.9" /TU="U1234" /idTUdmin="U1231" /TUdmin=328 /isTUend="FALSE" /label="downshifts" promotor_-35 1433951..1433954 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1433967..1434093 /Source="Nicolas_S_feature" /locus_tag="new_1552772_1552898" /HighExp="S1, T5.0H, T4.0H, HiOs, T3.30H, T3.0H, Etha, Heat, T2.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="0.619, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S541" upshifts 1433967 /Source="Nicolas_upshifts" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1433972..1433978 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1434094..1435305 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9622350, 12626683, 15849754, 16850406, 21386816, 27895631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 12626683, 15849754, 16850406, 21386816, 27895631; Product type t : transporter" /codon_start=1 /transl_table=11 /product="cell-division protein; transporter of lipid-linked cell wall precursors" /protein_id="NP_389368.1" /db_xref="EnsemblGenomes-Gn:BSU14850" /db_xref="EnsemblGenomes-Tr:CAB13358" /db_xref="GOA:O07639" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG13352" /db_xref="UniProtKB/Swiss-Prot:O07639" /translation="MLKKMLKSYDYSLIFAIVLLCGFGLVMVYSSSMITAVSRYGVSS NFFFMRQLFALIAGGALFILMALFPYKALAHQKFQKGILLVSVLALISLFVFGHVAGN AQSWFKIGGMSIQPGEFVKLVVILYLAAVYAKKQSYIDHLLTGVAPPVVMTLIICGLI AMQPDFGTAMIIGLIATCMILCSGFSGKTLVRLVILGGIVFILVSPIIYLNQDKILTE GRLARFESLEDPFKYANSSGLQVINSYYAISSGGIFGLGLGESIQKYGYLPESHTDFI MAVIAEELGIFGVLFVIFLLGFVVIKGFYIARKCEDPFGSLLAIGISSMIAIQSFINL GGVSGLIPITGVTLPFISYGGSSLVLLLGSMGILANISMFVKYSENKKKKEPLAPKGM KKKQLKKTVYL*" /label="ftsW CDS" gene 1434094..1435305 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /label="ftsW gene" promotor_-35 1435315..1435319 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1435334..1435353 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1435353 /Source="Nicolas_upshifts" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1435380..1438826 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /EC_number="6.4.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6425269, 15134465, 20081037, 20097852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate carboxylase" /protein_id="NP_389369.1" /db_xref="EnsemblGenomes-Gn:BSU14860" /db_xref="EnsemblGenomes-Tr:CAB13359" /db_xref="GOA:Q9KWU4" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR003379" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR005930" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG12660" /db_xref="UniProtKB/Swiss-Prot:Q9KWU4" /translation="MSQQSIQKVLVANRGEIAIRIFRACTELNIRTVAVYSKEDSGSY HRYKADEAYLVGEGKKPIDAYLDIEGIIDIAKRNKVDAIHPGYGFLSENIHFARRCEE EGIVFIGPKSEHLDMFGDKVKAREQAEKAGIPVIPGSDGPAETLEAVEQFGQANGYPI IIKASLGGGGRGMRIVRSESEVKEAYERAKSEAKAAFGNDEVYVEKLIENPKHIEVQV IGDKQGNVVHLFERDCSVQRRHQKVIEVAPSVSLSPELRDQICEAAVALAKNVNYINA GTVEFLVANNEFYFIEVNPRVQVEHTITEMITGVDIVQTQILVAQGHSLHSKKVNIPE QKDIFTIGYAIQSRVTTEDPQNDFMPDTGKIMAYRSGGGFGVRLDTGNSFQGAVITPY YDSLLVKLSTWALTFEQAAAKMVRNLQEFRIRGIKTNIPFLENVAKHEKFLTGQYDTS FIDTTPELFNFPKQKDRGTKMLTYIGNVTVNGFPGIGKKEKPAFDKPLGVKVDVDQQP ARGTKQILDEKGAEGLANWVKEQKSVLLTDTTFRDAHQSLLATRIRSHDLKKIANPTA ALWPELFSMEMWGGATFDVAYRFLKEDPWKRLEDLRKEVPNTLFQMLLRSSNAVGYTN YPDNVIKEFVKQSAQSGIDVFRIFDSLNWVKGMTLAIDAVRDTGKVAEAAICYTGDIL DKNRTKYDLAYYTSMAKELEAAGAHILGIKDMAGLLKPQAAYELVSALKETIDIPVHL HTHDTSGNGIYMYAKAVEAGVDIIDVAVSSMAGLTSQPSASGFYHAMEGNDRRPEMNV QGVELLSQYWESVRKYYSEFESGMKSPHTEIYEHEMPGGQYSNLQQQAKGVGLGDRWN EVKEMYRRVNDMFGDIVKVTPSSKVVGDMALYMVQNNLTEKDVYEKGESLDFPDSVVE LFKGNIGQPHGGFPEKLQKLILKGQEPITVRPGELLEPVSFEAIKQEFKEQHNLEISD QDAVAYALYPKVFTDYVKTTESYGDISVLDTPTFFYGMTLGEEIEVEIERGKTLIVKL ISIGEPQPDATRVVYFELNGQPREVVIKDESIKSSVQERLKADRTNPSHIAASMPGTV IKVLAEAGTKVNKGDHLMINEAMKMETTVQAPFSGTIKQVHVKNGEPIQTGDLLLEIE KA*" /label="pycA CDS" gene 1435380..1438826 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /label="pycA gene" promotor_-10 complement(1438392..1438410) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1438412) /Source="Nicolas_upshifts" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1438426..1438431) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1438806 /Source="Nicolas_upshifts" /id="D839" /incds=0 /nref=20 /ntot=213 /MaxReadThrough="5.5667" /MaxDrop="6.03063" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts 1438851 /Source="Nicolas_upshifts" /id="D840" /incds=0 /nref=2 /ntot=51 /MaxReadThrough="4.21552" /MaxDrop="4.9051" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=44 /isTUend="FALSE" /label="downshifts" downshifts complement(1438883) /Source="Nicolas_upshifts" /id="D841" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="2.24992" /MaxDrop="3.11732" /score="10.1921506" /energy="-11.8" /TU="NA" /idTUdmin="U1238" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 1438895 /Source="Nicolas_upshifts" /id="D842" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="3.6246" /MaxDrop="4.10361" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(1439229..1440149) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /EC_number="1.3.-.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12206660, 15491161, 15849754, 16321940, 16850406, 26592143" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12206660, 15491161, 15849754, 16321940, 16850406, 26592143; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heme-A synthase" /protein_id="NP_389370.1" /db_xref="EnsemblGenomes-Gn:BSU14870" /db_xref="EnsemblGenomes-Tr:CAB13360" /db_xref="GOA:P12946" /db_xref="InterPro:IPR003780" /db_xref="InterPro:IPR023755" /db_xref="SubtiList:BG10213" /db_xref="UniProtKB/Swiss-Prot:P12946" /translation="MNKALKALGVLTTFVMLIVLIGGALVTKTGSGQGCGRQWPLCHG RFFPELNPASIIEWSHRFASGISIILVLSLAFWSWRKITPIFRETTFLAIMSIIFLFL QALLGALAVVFGSNALIMALHFGISLISFASVLILTLLIFEADKSVRTLVKPLQIGKK MQFHMIGILIYSYIVVYTGAYVRHTESSLACPNVPLCSPLNNGLPTQFHEWVQMGHRA AALLLFVWIIVAAVHAITSYKDQKQIFWGWISCLIFITLQALSGIMIVYSELALGFAL AHSFFIACLFGVLCYFLLLIARFRYESRQS*" /label="ctaA CDS" gene complement(1439229..1440149) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /label="ctaA gene" downshifts complement(1439235) /Source="Nicolas_upshifts" /id="D843" /incds=0 /nref=126 /ntot=238 /MaxReadThrough="2.72676" /MaxDrop="5.67271" /score="28.8671863" /energy="-15.3" /TU="U1238" /idTUdmin="U1238" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1440189..1440208) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1440204) /Source="Nicolas_upshifts" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1440222..1440229) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1440284..1440291 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1440305..1440324 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1440306..1440411 /Source="Nicolas_S_feature" /locus_tag="new_1559111_1559216" /HighExp="LBGstat, M0t90, Lbstat, BC, T0.30H, T1.30H, B60, M9-stat, M40t90, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S542" upshifts 1440306 /Source="Nicolas_upshifts" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" S_feature 1440413..1440503 /Source="Nicolas_S_feature" /locus_tag="new_1559218_1559308" /HighExp="LBGstat, M0t90, LPhT, BC, UNK1, BI, Lbexp, LBGtran, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S543" upshifts 1440413 /Source="Nicolas_upshifts" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1440419..1440422 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1440437..1440453 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1440504..1441421 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protoheme IX farnesyltransferase 2" /protein_id="NP_389371.1" /db_xref="EnsemblGenomes-Gn:BSU14880" /db_xref="EnsemblGenomes-Tr:CAB13361" /db_xref="GOA:P24009" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG10214" /db_xref="UniProtKB/Swiss-Prot:P24009" /translation="MANSRILNDTAIDGQIEETTAWKDFLSLIKIGIVNSNLITTFTG MWLALHISGLSFLGNINTVLLTLIGSSLIIAGSCAINNWYDRDIDHLMERTKVRPTVT GKIQPSQALWSGILLVALGLIMLLMTTVMAAVIGFIGVFTYVVLYTMWTKRRYTINTV VGSVSGAVPPLIGWTAVEGNIGVVAWVLFMILFIWQIPHFLALAIKKTEDYRAANIPM LPVVYGFEVTKRQIIVWVACLMPLPFFLGSLGLPIVILGLLLNIGWLILGLMGFRSKN IMKWATQMFVYSLNYMTIYFVAMVVLTLF*" /label="ctaB CDS" gene 1440504..1441421 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /label="ctaB gene" downshifts 1441450 /Source="Nicolas_upshifts" /id="D844" /incds=0 /nref=33 /ntot=75 /MaxReadThrough="8.35391" /MaxDrop="5.6457" /score="0.893081758" /energy="-11.8" /TU="U1239,U1240" /idTUdmin="U1236" /TUdmin=1719 /isTUend="FALSE" /label="downshifts" upshifts 1441469 /Source="Nicolas_upshifts" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1441470..1441475 /Source="Nicolas_upshift_promotors" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1441529..1441534 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1441549..1441567 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1441557..1441660 /Source="Nicolas_S_feature" /locus_tag="new_1560362_1560465" /HighExp="Lbstat, M0t90, M40t90, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, Sig-, SigA, SigA" /TUshortPSig="0.451, 0.407, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S544" upshifts 1441557 /Source="Nicolas_upshifts" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" CDS 1441661..1442731 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 9829923, 9882689, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 9829923, 9882689, 27503613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit II)" /protein_id="NP_389372.1" /db_xref="EnsemblGenomes-Gn:BSU14890" /db_xref="EnsemblGenomes-Tr:CAB13362" /db_xref="GOA:P24011" /db_xref="InterPro:IPR001505" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR014222" /db_xref="InterPro:IPR034236" /db_xref="InterPro:IPR036257" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10215" /db_xref="UniProtKB/Swiss-Prot:P24011" /translation="MVKHWRLILLLALVPLLLSGCGKPFLSTLKPAGEVADKQYDLTV LSTLIMVVVVAVVSVIFFYVIVRFRRSRVGENTIPKQVEGNKFLEITWTVIPILLLII LVIPVVLYTLELADTSPMDKKGRKAEDALVVNVRANLYWWEFEYPDYGIITSQELIVP TDQRVYFNLKASDVKHSFWIPSVGGKLDTNTDNENKFFLTFDSKRSKEAGDMFFGKCA ELCGPSHALMDFKVKTMSAKEFQGWTKEMKNYKSTAESDLAKQGEELFKEKNCLSCHA VEPNDKRAEAARTAPNLATFGERTKVAGVKEANKENVKAWLKDPDSIKPGNKMTGTYP KLSDSETNALYEYLKGLKAESK*" /label="ctaC CDS" gene 1441661..1442731 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /label="ctaC gene" CDS 1442764..1444632 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit I)" /protein_id="NP_389373.2" /db_xref="EnsemblGenomes-Gn:BSU14900" /db_xref="EnsemblGenomes-Tr:CAB13363" /db_xref="GOA:P24010" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014241" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10216" /db_xref="UniProtKB/Swiss-Prot:P24010" /translation="MLNALTEKRTRGSMLWDYLTTVDHKKIAILYLVAGGFFFLVGGI EAMFIRIQLAKPENAFLSAQAYNEVMTMHGTTMIFLAAMPLLFALMNAVVPLQIGARD VSFPFLNALGFWLFFFGGIFLNLSWFLGGAPDAGWTSYASLSLHSKGHGIDFFVLGLQ ISGLGTLIAGINFLATIINMRAPGMTYMRLPLFTWTTFVASALILFAFPPLTVGLALM MLDRLFGTNFFNPELGGNTVIWEHLFWIFGHPEVYILILPAFGIFSEVIPVFARKRLF GYSSMVFAIVLIGFLGFMVWVHHMFTTGLGPIANAIFAVATMAIAIPTGIKIFNWLLT IWGGNVKYTTAMLYAVSFIPSFVLGGVTGVMLAAAAADYQFHDTYFVVAHFHYVIIGG VVFGLLAGVHFWWPKMFGKILHETMGKISFVLFFIGFHLTFFIQHFVGLMGMPRRVYT FLPGQGLETGNLISTIGAFFMAAAVILLLVNVIWTSVKGEYVGADPWHDGRTLEWTVS SPPPEYNFKQLPFVRGLDPLWIEKQAGHKSMTPAEPVDDIHMPNGSILPLIISFGLFV AAFGLLYRSDYAWGLPVIFIGLGITFITMLLRSVIDDHGYHIHKEELPNDDKGVKA*" /label="ctaD CDS" gene 1442764..1444632 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /label="ctaD gene" CDS 1444632..1445255 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit III)" /protein_id="NP_389374.1" /db_xref="EnsemblGenomes-Gn:BSU14910" /db_xref="EnsemblGenomes-Tr:CAB13364" /db_xref="GOA:P24012" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10217" /db_xref="UniProtKB/Swiss-Prot:P24012" /translation="MQVQEKFTAETFPASPEKVTLEGKNKFLGFWLFLGGETVLFASL FATFLALRNSNAGDPPTTEMFDVTLVFIATMLLLTSSLTSVYAMYHMKNFSFGKMQLW LGITILLGAGFLGLEIYEFKHYTHEFGFTITSSALGSAFYTLVGTHGAHVAFGLMWIS TLMIRNAKRGLNLYTAPKFYVASLYWHFIDVVWVFIFTVVYLMGMVG*" /label="ctaE CDS" gene 1444632..1445255 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /label="ctaE gene" CDS 1445258..1445590 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit IV)" /protein_id="NP_389375.1" /db_xref="EnsemblGenomes-Gn:BSU14920" /db_xref="EnsemblGenomes-Tr:CAB13365" /db_xref="GOA:P24013" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014257" /db_xref="SubtiList:BG10218" /db_xref="UniProtKB/Swiss-Prot:P24013" /translation="MVDKKSRGHINSDLEFKKKKHAREMKYQVLSFGLMIGLTIVAFL TVATDGVGSWFTIPFIILLAAIQVIFQLYYFMHMNQKGHEAPALFLYSGVFVAFITVL AFVTIIWW*" /label="ctaF CDS" gene 1445258..1445590 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /label="ctaF gene" CDS 1445617..1446510 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /function="16.10: Respire" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14766920, 15849754, 16305244, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14766920, 15849754, 16305244, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome aa(3) assembly factor" /protein_id="NP_389376.1" /db_xref="EnsemblGenomes-Gn:BSU14930" /db_xref="EnsemblGenomes-Tr:CAB13366" /db_xref="GOA:O34329" /db_xref="InterPro:IPR014108" /db_xref="InterPro:IPR019108" /db_xref="SubtiList:BG12579" /db_xref="UniProtKB/Swiss-Prot:O34329" /translation="MNQLEIFGFRAMWSPYLFCILLGITALYLYFYRRMSSKPNRITG KEMVCFLSAMLFLYAAEGSPVDLLGHIMFSAHMVQMAVLYLVVPPLLIAGIPAWLWEK IIFRPSIKPVFSFFTTPLIALLLFNGIFSLYHVPLIFDTVKTDPFYHTLITWLIFVLA FFMWWPLVHKVERLRQLSGLMKLGYIMADGMLLTPACALIMFSGAPLYATYTDPALWA EAMRLCVPADMMGQVPLTGPEMLNTLPLLEDQQLGAVMMKIIQEIVYGTFLAVIFFQW VKKEREKDGQEEPPYIQQTIS*" /label="ctaG CDS" gene 1445617..1446510 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /label="ctaG gene" downshifts 1446485 /Source="Nicolas_upshifts" /id="D845" /incds=0 /nref=121 /ntot=229 /MaxReadThrough="1.94099" /MaxDrop="5.91271" /score="4.35633365" /energy="-13.3" /TU="NA" /idTUdmin="U1239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1446542..1446904) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389377.1" /db_xref="EnsemblGenomes-Gn:BSU14940" /db_xref="EnsemblGenomes-Tr:CAB13367" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG13353" /db_xref="UniProtKB/Swiss-Prot:O34743" /translation="MLKFTESGLEGVKAELSWLDDLMESKGLIRAGQWDYERVTYDKK FSTIEGTFYLRIQGIAAEGDVGSGRAVIQLMSPLLGKHYYPHGVEYGETEEFPVQVVT KSKALIQDIANMLKTVQM*" /label="ylbA CDS" gene complement(1446542..1446904) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /label="ylbA gene" downshifts complement(1446561) /Source="Nicolas_upshifts" /id="D846" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="1.00586" /MaxDrop="6.68145" /score="-3.42191479" /energy="-11.2" /TU="NA" /idTUdmin="U1244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1446897..1446901 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1446910..1446923 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1446928..1446947) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1446932..1447043 /Source="Nicolas_S_feature" /locus_tag="new_1565737_1565848" /HighExp="S7, S8, S4, S3, S6, S5, T5.0H, T4.0H, BC, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.368" /TUlongSig="NA" /TUlongPSig="NA" /label="S545" upshifts 1446932 /Source="Nicolas_upshifts" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1446940) /Source="Nicolas_upshifts" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1446962..1446969) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1447044..1447490 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389378.2" /db_xref="EnsemblGenomes-Gn:BSU14950" /db_xref="EnsemblGenomes-Tr:CAB13368" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG13354" /db_xref="UniProtKB/Swiss-Prot:O34682" /translation="MTKIKDLMTADLQYCTVLDNVYEAAVKMKDANVGAIPVVDEDGE TLVGIVTDRDLVLRGIAIKKPNSQKITDAMTEKPVSVEEDASVDEVLHLMASHQLRRI PVTKNKKLTGIVTLGDLSLSEQTNERAGSALSDISEGDNREEGFFH*" /label="ylbB CDS" gene 1447044..1447490 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /label="ylbB gene" promotor_-35 1447076..1447083 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1447095..1447114 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1447100 /Source="Nicolas_upshifts" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1447499..1447506 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1447520..1447539 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1447531 /Source="Nicolas_upshifts" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" CDS 1447574..1448614 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389379.1" /db_xref="EnsemblGenomes-Gn:BSU14960" /db_xref="EnsemblGenomes-Tr:CAB13369" /db_xref="GOA:O34586" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR029410" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13355" /db_xref="UniProtKB/Swiss-Prot:O34586" /translation="MKNILRAMVILLIICGTYVLFIQYGSVPEKKSNDSEPQVSNEEA QSGKRIHMPTSGLLSFMGKHADEVTKKLGEPERIDPSAYDYDWWVYNQGKDQYIQIGV LNNKVVTLFASGNDINAKPFKIGESTGEVFKTTQVAPFVNVEYKGNSYRFEFSEEDIN TRPTVKVGKMYVQLYMDKFEGKLSSIRAFDAQTFVKQRPYEVVYRGELIKPKAVSDEK WKKIQTTSEKQILDLTNVIRVKHGLAKLEWDQPTAEVAFGHSEDMKENNYFSHVSKKY GSLKDRLEEGHVDFQQAGENIAYNYVDGPAAVEGWLNSEGHRKALLNSDYTHLGVGVD RKYYTQNFIKRW*" /label="ylbC CDS" gene 1447574..1448614 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /label="ylbC gene" promotor_-10 complement(1448537..1448555) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1448542) /Source="Nicolas_upshifts" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1448571..1448576) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1448594 /Source="Nicolas_upshifts" /id="D847" /incds=0 /nref=84 /ntot=252 /MaxReadThrough="1.59604" /MaxDrop="4.17709" /score="-1.16631837" /energy="-8.1" /TU="NA" /idTUdmin="U1243" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 1448778..1448787 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1448801..1448820 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1448815 /Source="Nicolas_upshifts" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="upshifts" CDS 1448846..1449244 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19775244, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related protein (coat)" /protein_id="NP_389380.1" /db_xref="EnsemblGenomes-Gn:BSU14970" /db_xref="EnsemblGenomes-Tr:CAB13370" /db_xref="InterPro:IPR025953" /db_xref="SubtiList:BG13356" /db_xref="UniProtKB/Swiss-Prot:O34880" /translation="MANQHANHSINDFKQFVKKHPKLIKEVRKEQRSWQDVYENWVLF GESDPIWDPYREPEEASEAVPETPQKNDFVSKMVTAVKKMDVNQMNEQINKMSQSISS LQSLLNTFSGSGQKHSQPGSGQHPFSFRKD*" /label="ylbD CDS" gene 1448846..1449244 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /label="ylbD gene" downshifts complement(1448850) /Source="Nicolas_upshifts" /id="D848" /incds=0 /nref=2 /ntot=11 /MaxReadThrough="2.37349" /MaxDrop="4.0378" /score="40.2648817" /energy="-14.3" /TU="NA" /idTUdmin="U1247" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS 1449260..1449499 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389381.1" /db_xref="EnsemblGenomes-Gn:BSU14980" /db_xref="EnsemblGenomes-Tr:CAB13371" /db_xref="InterPro:IPR025613" /db_xref="SubtiList:BG13357" /db_xref="UniProtKB/Swiss-Prot:O34958" /translation="MRKEVQEYILANEERKRFIREQPIWYRRLSRKPDDLSSFQLEMM NFYEKTIPHRVNQFTNGIQMAQMMMQMFQAMRTKD*" /label="ylbE CDS" gene 1449260..1449499 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /label="ylbE gene" downshifts 1449478 /Source="Nicolas_upshifts" /id="D849" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="2.09257" /MaxDrop="4.65792" /score="-7.8200921" /energy="-5.1" /TU="NA" /idTUdmin="U1248" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1449566..1449573 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1449584..1449603 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1449589 /Source="Nicolas_upshifts" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1449615..1450064 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex controlling RNase Y (RicAFTcomplex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389382.1" /db_xref="EnsemblGenomes-Gn:BSU14990" /db_xref="EnsemblGenomes-Tr:CAB13372" /db_xref="GOA:O34412" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="SubtiList:BG13358" /db_xref="UniProtKB/Swiss-Prot:O34412" /translation="MYATMESVRLQSEAQQLAEMILQSETAENYRNCYKRLQEDEEAG RIIRSFIKIKEQYEDVQRFGKYHPDYREISRKMREIKRELDLNDKVADFKRAENELQS ILDEVSVEIGTAVSEHVKVPTGNPYFDGLSSCGGGCGSGGSCGCKVS*" /label="ricF CDS" gene 1449615..1450064 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /label="ricF gene" downshifts 1450050 /Source="Nicolas_upshifts" /id="D850" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="5.95111" /MaxDrop="2.83" /score="-4.2014677" /energy="-11.5" /TU="U1249" /idTUdmin="U1248" /TUdmin=572 /isTUend="FALSE" /label="downshifts" CDS 1450119..1450391 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10712692, 21532344, 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389383.1" /db_xref="EnsemblGenomes-Gn:BSU15000" /db_xref="EnsemblGenomes-Tr:CAB13373" /db_xref="GOA:O34658" /db_xref="InterPro:IPR016979" /db_xref="SubtiList:BG13359" /db_xref="UniProtKB/Swiss-Prot:O34658" /translation="MENRRQGMVVYLHSLKQSKMLRKFGNVHYVSKRLKYVVLYCDMD QIEKTMDKIASYSFVKKVEPSYKPFLKLEFESKLDKAKEYDYKIGI*" /label="ylbG CDS" gene 1450119..1450391 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /label="ylbG gene" S_feature complement(1450196..1450419) /Source="Nicolas_S_feature" /locus_tag="new_1569001_1569224_c" /HighExp="S8, S7, S4, S5, S6, S3, C30, BT, G135, C90" /AntisenseName="ylbG" /AntisenseCor="-0.668594452827031" /AntisenseRegPval="-35.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S546" misc_RNA 1450394..1450514 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /product="sporulation-specific regulatory RNA" /experiment="publication(s) with functional evidences, PMID:21532344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21532344; Product type n: RNA" /function="15.7: Sporulation and germination" /label="csfG RNA" gene 1450394..1450514 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /label="csfG gene" S_feature complement(1450421..1450544) /Source="Nicolas_S_feature" /locus_tag="new_1569226_1569349_c" /HighExp="S3, S8, S7, G/S, S4, S5, Pyr, S6, B36, BT" /AntisenseName="NA" /AntisenseCor="-0.69279578575099399" /AntisenseRegPval="-39.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S547" downshifts complement(1450464) /Source="Nicolas_upshifts" /id="D851" /incds=0 /nref=61 /ntot=131 /MaxReadThrough="3.9368" /MaxDrop="7.78892" /score="40.2648817" /energy="-14.3" /TU="U1250" /idTUdmin="U1250" /TUdmin="-228" /isTUend="FALSE" /label="downshifts" S_feature 1450515..1450620 /Source="Nicolas_S_feature" /locus_tag="new_1569320_1569425" /HighExp="H2O2, Paraq, Oxctl, G180, G135, G150, Cold, C30, Diami, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S548" promotor_-10 complement(1450545..1450557) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1450552) /Source="Nicolas_upshifts" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1450572..1450578) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1450601..1450605 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-35" promotor_-10 1450621..1450640 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-10" S_feature 1450622..1450713 /Source="Nicolas_S_feature" /locus_tag="new_1569427_1569518" /HighExp="H2O2, G135, Oxctl, Paraq, G180, dia0, G150, Lbexp, LBGexp, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S549" upshifts 1450622 /Source="Nicolas_upshifts" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="upshifts" CDS 1450714..1451268 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /EC_number="2.1.1.171" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 17389639, 22535590, 22649054; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m2G966 methyltransferase" /protein_id="NP_389384.2" /db_xref="EnsemblGenomes-Gn:BSU15010" /db_xref="EnsemblGenomes-Tr:CAB13374" /db_xref="GOA:O34331" /db_xref="InterPro:IPR004398" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13360" /db_xref="UniProtKB/Swiss-Prot:O34331" /translation="MRVISGSKKGRSLKAVAGTSTRPTTDKVKESIFNMIGPYFDGGR GLDLFAGSGGLGIEALSRGFEHCIFVDRDFKAIQTVKSNLKTLELTKHAQVYRNDAER ALHAAAKRETGFRGIFLDPPYKEQKLKALLTLIDEYQMLEEDGFIVAEHDREVELPET VGDLVMTRKETYGLTGVAIYKKRG*" /label="rsmD CDS" gene 1450714..1451268 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /label="rsmD gene" CDS 1451273..1451758 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /EC_number="2.7.7.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10480925, 10939241, 16014871, 21912874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphopantetheine adenylyltransferase" /protein_id="NP_389385.1" /db_xref="EnsemblGenomes-Gn:BSU15020" /db_xref="EnsemblGenomes-Tr:CAB13375" /db_xref="GOA:O34797" /db_xref="InterPro:IPR001980" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="PDB:1O6B" /db_xref="SubtiList:BG13361" /db_xref="UniProtKB/Swiss-Prot:O34797" /translation="MASIAVCPGSFDPVTYGHLDIIKRGAHIFEQVYVCVLNNSSKKP LFSVEERCELLREVTKDIPNITVETSQGLLIDYAKRKNAKAILRGLRAVSDFEYEMQG TSVNRVLDESIETFFMMTNNQYSFLSSSIVKEVARYNGSVSEFVPPEVELALQQKFRQ G*" /label="coaD CDS" gene 1451273..1451758 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /label="coaD gene" downshifts 1451725 /Source="Nicolas_upshifts" /id="D852" /incds=0 /nref=26 /ntot=196 /MaxReadThrough="3.45558" /MaxDrop="3.85134" /score="13.7782945" /energy="-7.8" /TU="U1249,U1251" /idTUdmin="U1251" /TUdmin="-1296" /isTUend="FALSE" /label="downshifts" CDS complement(1451769..1452995) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15849754, 16850406, 28945739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15849754, 16850406, 28945739; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipicolinic acid transporter (to the spore)" /protein_id="NP_389386.1" /db_xref="EnsemblGenomes-Gn:BSU15030" /db_xref="EnsemblGenomes-Tr:CAB13376" /db_xref="GOA:O34765" /db_xref="InterPro:IPR011642" /db_xref="InterPro:IPR014226" /db_xref="SubtiList:BG13362" /db_xref="UniProtKB/Swiss-Prot:O34765" /translation="MNLSKINTLLIASFFLFLTATVISHPQASFEASKTGLSMWWEVV FPSLLPFFILSELLIGFGIVRFVGVLLEPFMRPIFRVPGVGGFVLAMGMASGNPAGAK LTARLRQENQISRVEAERLASFTNSSNPLFIFGAVAVGFFQNASLGILLASAHYLGNL AVGLTMRSYGRKEEQHLRRKKTIPFPSVKDALHALHTARLAEKRPLGKILGDAVTSSV QTLLMVGGFIILFSVFNRLLSVVQLTDVLSVFTKGALTLFQLPTQLDIPLLSGMFEIT LGSKLVSETDVSLLQKAIIVSFILGFSGFSVQAQVAGILSETDIRFKPFFIARLLQGV YAAVFVMLLWKPLYTAWHDPYQYVFKSLNSSDMSTAFINGWNLLVQIGPAVTLCALFT YIIIFSYRLTNGTKKG*" /label="spoVV CDS" gene complement(1451769..1452995) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /label="spoVV gene" S_feature 1451770..1453044 /Source="Nicolas_S_feature" /locus_tag="new_1570575_1571849" /HighExp="H2O2, G135, Paraq, G150, G180, Oxctl, LBGexp, dia0, dia15, Mt0" /AntisenseName="ylbJ" /AntisenseCor="-0.54237424349391605" /AntisenseRegPval="-21.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S550" S_feature complement(1452996..1453097) /Source="Nicolas_S_feature" /locus_tag="new_1571801_1571902_c" /HighExp="LoTm, S3, S4, S5, T5.0H, M9-stat, T4.0H, S6, BT, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S551" promotor_-35 1453019..1453026 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1453038..1453057 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1453046..1453175 /Source="Nicolas_S_feature" /locus_tag="new_1571851_1571980" /HighExp="Etha, dia15, dia5, Diami, H2O2, Lbtran, LBGtran, Paraq, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S552" upshifts 1453046 /Source="Nicolas_upshifts" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1453092..1453110) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1453107) /Source="Nicolas_upshifts" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1453127..1453132) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1453176..1453958 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389387.1" /db_xref="EnsemblGenomes-Gn:BSU15040" /db_xref="EnsemblGenomes-Tr:CAB13377" /db_xref="GOA:O34731" /db_xref="InterPro:IPR001423" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG13363" /db_xref="UniProtKB/Swiss-Prot:O34731" /translation="MAKPKIGLALGSGGARGLAHLGVLSSLHKHQIEVDMIAGSSMGA LVGSFYAAGHDVATMKKVAKAFKRRLYADYTVPKLGFLKGDRVRQLVHAYTFGKPIEE LQIPLGIVACDLQTGEKIVFRKGSVSDAVRASISIPGIFIPQRLDGRLLVDGAVVDRI PVSVVKDMGADIIIASDVSRVRKTETAVHIFDVIMQSMDILQNELVRHQTIAADIMIR PSLETYSSSSFANIEEMISAGEEATNRMISKIRKEIENWEGS*" /label="ylbK CDS" gene 1453176..1453958 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /label="ylbK gene" promotor_-35 1453738..1453744 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1453758..1453769 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1453769 /Source="Nicolas_upshifts" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1453960..1454985 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradative enzyme" /protein_id="NP_389388.2" /db_xref="EnsemblGenomes-Gn:BSU15050" /db_xref="EnsemblGenomes-Tr:CAB13378" /db_xref="GOA:O34470" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR036034" /db_xref="PDB:2KJP" /db_xref="SubtiList:BG13364" /db_xref="UniProtKB/Swiss-Prot:O34470" /translation="MLRKKHFSWMLVILILIAVLSFIKLPYYITKPGEATELASLIKV EGGYPEKGSLSLMTVKVGPANPFTYVWAKMHPYYEIVPDESIKEEGESDKEYMKRQLQ MMKSSQENAVIAAYQKAGKKVSYSFNGIYASSVVENMPAKGKIEVGDKIISADGKNYQ SAEKLIDYISSKKAGDKVTLKIEREEKEKRVTLTLKQFPDEPDRAGIGVSLYTDRNVK VEPDIDFEIENIGGPSAGLMMSLEIYNQLTKPDETKGYDIAGTGTIDVDGKVGPIGGI DQKVVAADKAGKDIFFAPNQNGASNSDYKNAVKTAKDIDSNMKIVPVDTMQDAIDYLN KLKAKST*" /label="ylbL CDS" gene 1453960..1454985 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /label="ylbL gene" downshifts 1454869 /Source="Nicolas_upshifts" /id="D853" /incds=1 /nref=59 /ntot=235 /MaxReadThrough="2.38639" /MaxDrop="3.52503" /score="19.0874959" /energy="-11.5" /TU="NA" /idTUdmin="U1249" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1455002..1456249) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 19215769; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative component of the degradosome" /protein_id="NP_389389.1" /db_xref="EnsemblGenomes-Gn:BSU15060" /db_xref="EnsemblGenomes-Tr:CAB13379" /db_xref="InterPro:IPR008513" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13365" /db_xref="UniProtKB/Swiss-Prot:O34513" /translation="MKAVGLVVEYNPFHNGHLYHAQTAKLQTGCDTAVAVMSGHFLQR GEPAVVSKWARTKMALQSGVDLVIELPYLYAVQKADIFARGSVSILNELECEALFFGS ENGDIKPFLETAQLIDEHKHILNDRIKEELKKGASYPAAAAIAFSSILHTESALDLSK PNNILGYQYVTSILTGGYPMKPYTTARISSDYHDADLPEGENHIASATSIRKAMIGQN LEACLRFLPAASARELAAYRKSFGLWHTPESYFSYLKYSLSTVTARELQQVYEVEEGL EHRIIRSIRKSSSYQEFMELLKTKRYTWTRLQRMNTHILTRTKKQDMQKLLDNDKAPY IRLLGMTKKGQAYLSEKKKALSVPLVSKLSSFSHPALDLDVKASRIYSLPIEEPLRTE FDLQEYGHAPIRYDEDEQHFLNV*" /label="ylbM CDS" gene complement(1455002..1456249) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /label="ylbM gene" downshifts complement(1455029) /Source="Nicolas_upshifts" /id="D854" /incds=0 /nref=8 /ntot=182 /MaxReadThrough="1.58661" /MaxDrop="3.70777" /score="4.49214865" /energy="-11.5" /TU="NA" /idTUdmin="U1257" /TUdmin=775 /isTUend="FALSE" /label="downshifts" promotor_-35 1456166..1456172 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-35" promotor_-10 1456186..1456197 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-10" upshifts 1456190 /Source="Nicolas_upshifts" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="upshifts" CDS complement(1456246..1456431) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein,of unknown function" /protein_id="YP_003097727.1" /db_xref="EnsemblGenomes-Gn:BSU15069" /db_xref="EnsemblGenomes-Tr:CAX52618" /db_xref="UniProtKB/Swiss-Prot:C0H411" /translation="MIIAFKIVFVNIFSLQHNAAIEVSLTAEYAMHTLKTKIRRKSFH LQMYHTFLNIARKAEKI*" /label="ylzH CDS" gene complement(1456246..1456431) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /label="ylzH gene" promotor_-35 1456264..1456268 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-35" promotor_-10 1456284..1456303 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-10" S_feature 1456293..1456428 /Source="Nicolas_S_feature" /locus_tag="new_1575098_1575233" /HighExp="Cold, LoTm, Diami, Paraq, H2O2, Oxctl, G180, dia5, G135, LBGexp" /AntisenseName="ylzH" /AntisenseCor="-9.1134498265910996E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S553" upshifts 1456293 /Source="Nicolas_upshifts" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="upshifts" promotor_-10 complement(1456322..1456341) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1456332) /Source="Nicolas_upshifts" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1456355..1456362) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1456399..1456406 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1456420..1456439 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1456430 /Source="Nicolas_upshifts" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1456459..1456977 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11700356, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389390.1" /db_xref="EnsemblGenomes-Gn:BSU15070" /db_xref="EnsemblGenomes-Tr:CAB13380" /db_xref="InterPro:IPR003772" /db_xref="SubtiList:BG13366" /db_xref="UniProtKB/Swiss-Prot:O34445" /translation="MKWTIYQLHQMPKQSFEFDETVELNELTKLNSDIRRISPVRVKG RADIKSKQVSFDFTISGEMLLPCSRTLVDVPYPFEISTKELFIFHHTDDIEDDDVHIV EDDTIDITPIVKEEILLEIPMQIFCESEQEKGAAPQEGKDWQVISEEDKKNQVDPRLA ALEKLLKQDDES*" /label="ylbN CDS" gene 1456459..1456977 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /label="ylbN gene" CDS 1456999..1457178 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L32" /protein_id="NP_389391.1" /db_xref="EnsemblGenomes-Gn:BSU15080" /db_xref="EnsemblGenomes-Tr:CAB13381" /db_xref="GOA:O34687" /db_xref="InterPro:IPR002677" /db_xref="InterPro:IPR011332" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12668" /db_xref="UniProtKB/Swiss-Prot:O34687" /translation="MAVPFRRTSKMKKRLRRTHFKLNVPGMTECPSCGEMKLSHRVCK ACGSYNGKDINVKSN*" /label="rpmF CDS" gene 1456999..1457178 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /label="rpmF gene" downshifts 1457158 /Source="Nicolas_upshifts" /id="D855" /incds=0 /nref=232 /ntot=266 /MaxReadThrough="5.64002" /MaxDrop="7.70407" /score="53.0065581" /energy="-17.1" /TU="U1258" /idTUdmin="U1256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1457201) /Source="Nicolas_upshifts" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1457205..1457208) /Source="Nicolas_upshift_promotors" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1457259..1457264 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1457280..1457298 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1457281 /Source="Nicolas_upshifts" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1457324..1457905 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15621419, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15621419, 20435725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="DNA-binding regulator" /protein_id="NP_389392.1" /db_xref="EnsemblGenomes-Gn:BSU15090" /db_xref="EnsemblGenomes-Tr:CAB13382" /db_xref="GOA:O34549" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017930" /db_xref="SubtiList:BG13367" /db_xref="UniProtKB/Swiss-Prot:O34549" /translation="MTITRQDAWTQDEDLLLAEVVLRHIREGGTQLSAFEEVGRALTR TAAACGFRWNSYVRKQYQSGIELAKKQRKELRKQIGVHSVNMPNSMKQTASASSEGKR DLSIQDVIQFLEQFKETPSAQEFQLEREKLKEQIQSLQKELEDLRSENQTLRNQLEMT EEDYKALIDIMDRARKMVVSKEDGRMKKAAQET*" /label="gerR CDS" gene 1457324..1457905 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /label="gerR gene" downshifts 1457906 /Source="Nicolas_upshifts" /id="D856" /incds=0 /nref=56 /ntot=139 /MaxReadThrough="2.70626" /MaxDrop="5.6861" /score="-7.71867756" /energy="-12.8" /TU="U1260" /idTUdmin="U1258" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1457962..1458444) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389393.2" /db_xref="EnsemblGenomes-Gn:BSU15100" /db_xref="EnsemblGenomes-Tr:CAB13383" /db_xref="GOA:O34468" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017274" /db_xref="PDB:2PR1" /db_xref="SubtiList:BG13368" /db_xref="UniProtKB/Swiss-Prot:O34468" /translation="MTKVERLLINYKTLEEFKKFKEYGIQELSMLEELQDNIIENDST SPFYGIYFGDKLVARMSLYQVNGKSNPYFDNRQDYLELWKLEVLPGYQNRGYGRALVE FAKSFKMPIRTNPRMKSAEFWNKMNFKTVKYDMARDKGENPLIWHPDMDREMTPGESA *" /label="ylbP CDS" gene complement(1457962..1458444) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /label="ylbP gene" downshifts complement(1457981) /Source="Nicolas_upshifts" /id="D857" /incds=0 /nref=90 /ntot=231 /MaxReadThrough="3.90092" /MaxDrop="6.59996" /score="14.5482917" /energy="-14.5" /TU="U1261" /idTUdmin="U1261" /TUdmin="-615" /isTUend="FALSE" /label="downshifts" downshifts 1458434 /Source="Nicolas_upshifts" /id="D858" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.3013" /MaxDrop="4.42908" /score="-7.71867756" /energy="-12.8" /TU="NA" /idTUdmin="U1260" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1458467..1458486) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1458486) /Source="Nicolas_upshifts" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1458500..1458507) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1458544..1458550 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-35" promotor_-10 1458562..1458581 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-10" upshifts 1458564 /Source="Nicolas_upshifts" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="upshifts" CDS 1458604..1459500 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1844812, 10736170, 23894131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1844812, 10736170, 23894131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate 2-reductase" /protein_id="NP_389394.1" /db_xref="EnsemblGenomes-Gn:BSU15110" /db_xref="EnsemblGenomes-Tr:CAB13384" /db_xref="GOA:O34661" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="PDB:3EGO" /db_xref="SubtiList:BG13369" /db_xref="UniProtKB/Swiss-Prot:O34661" /translation="MKIGIIGGGSVGLLCAYYLSLYHDVTVVTRRQEQAAAIQSEGIR LYKGGEEFRADCSADTSINSDFDLLVVTVKQHQLQSVFSSLERIGKTNILFLQNGMGH IHDLKDWHVGHSIYVGIVEHGAVRKSDTAVDHTGLGAIKWSAFDDAEPDRLNILFQHN HSDFPIYYETDWYRLLTGKLIVNACINPLTALLQVKNGELLTTPAYLAFMKLVFQEAC RILKLENEEKAWERVQAVCGQTKENRSSMLVDVIGGRQTEADAIIGYLLKEASLQGLD AVHLEFLYGSIKALERNTNKVF*" /label="panE CDS" gene 1458604..1459500 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /label="panE gene" CDS 1459571..1461190 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /EC_number="6.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16169927, 19578333, 20308541, 20799687, 25496067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16169927, 19578333, 20308541, 20799687, 25496067; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate glucosamine cysteine ligase" /protein_id="NP_389395.2" /db_xref="EnsemblGenomes-Gn:BSU15120" /db_xref="EnsemblGenomes-Tr:CAB13385" /db_xref="GOA:P55342" /db_xref="InterPro:IPR011199" /db_xref="PDB:4WBD" /db_xref="SubtiList:BG11424" /db_xref="UniProtKB/Swiss-Prot:P55342" /translation="MQLTELSIKNQNVFVQHYIDGKEEMSSFFDYSIHHKDMWRERLE DLSSRFFAREELAAYLTSYHNKFGSSAMQSAIEKLKDPSSAAVVGGQQAGLLTGPLYT IHKIISIIVLAKQQEKELQVPVIPIFWVAGEDHDLDEINFVHTSEENGPVKKKLPQSY WKKSSAASTSLDQEKCAAWIDDVFAAFEETDHTNTLLDNVKRCLRESVTFTDFFELLI ADLFQEEGLVLLNSGDPGIKKLETAMFQKILRENDELARAVSDQQAFMRQAGYKPIIE SGKEQANLFYEYEDERFLIEKDNGRFVIKELDLGWTRDELHTHMEEHPERFSNNVVTR PLMQEFLIPTLAFIAGPGEINYWGELKQAFAVMGFKMPPVMPRLNITILERHIEKKLA ERNISLQDAIERGTENQRETYFERQIPEEFTAVMDQAKSQIEAIHKTVRQEALKVDQS LEPLLLKNAAFIQDQLQFLERTVMKRIEEKEGYVLKDYERIQNSIKPLLAPQERIWNI MYYLNRYGPKFFTTFKNLPFSFQNQHQVVKL*" /label="bshC CDS" gene 1459571..1461190 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /label="bshC gene" downshifts 1461162 /Source="Nicolas_upshifts" /id="D859" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="3.87099" /MaxDrop="3.76832" /score="34.9463932" /energy="-8.3" /TU="U1262" /idTUdmin="U1262" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 1461224..1461227 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1461242..1461315 /Source="Nicolas_S_feature" /locus_tag="new_1580047_1580120" /HighExp="M9-stat, T5.0H, T3.0H, Lbstat, Lbtran, T2.30H, T1.30H, M0t90, T1.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="SigA" /TUlongPSig=1 /label="S554" promotor_-10 1461242..1461261 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1461242 /Source="Nicolas_upshifts" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1461299) /Source="Nicolas_upshifts" /id="D860" /incds=0 /nref=17 /ntot=137 /MaxReadThrough="3.30554" /MaxDrop="4.47473" /score="-9.92306593" /energy="-12" /TU="NA" /idTUdmin="U1264" /TUdmin=1149 /isTUend="FALSE" /label="downshifts" CDS 1461316..1461747 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /function="16.13: Shape" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10572301, 15939023, 16511046, 24659771, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of RsmH and transcriptional regulator" /protein_id="NP_389396.1" /db_xref="EnsemblGenomes-Gn:BSU15130" /db_xref="EnsemblGenomes-Tr:CAB13386" /db_xref="GOA:P55343" /db_xref="InterPro:IPR003444" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR020603" /db_xref="InterPro:IPR035642" /db_xref="InterPro:IPR035644" /db_xref="SubtiList:BG11425" /db_xref="UniProtKB/Swiss-Prot:P55343" /translation="MFMGEYQHTIDAKGRMIVPAKFREGLGEQFVLTRGLDQCLFGYP MHEWKQIEEKLKALPLTKKDARAFTRFFFSGATECELDKQGRVNIASSLLNYAKLEKE CVVIGVSNRIELWSKVIWEQYTEEQEDSFAEIAENMIGFDI*" /label="mraZ CDS" gene 1461316..1461747 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /label="mraZ gene" CDS 1461817..1462752 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /EC_number="2.1.1.199" /function="16.6: Maintain" /function="16.13: Shape" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9294438, 9721276, 10572301, 16849811, 19965768, 20924196, 22561317, 27711192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m4C1402 methyltransferase" /protein_id="NP_389397.1" /db_xref="EnsemblGenomes-Gn:BSU15140" /db_xref="EnsemblGenomes-Tr:CAB13387" /db_xref="GOA:Q07876" /db_xref="InterPro:IPR002903" /db_xref="InterPro:IPR023397" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10219" /db_xref="UniProtKB/Swiss-Prot:Q07876" /translation="MFQHKTVLLRETVDGLNIKPDGTYVDCTLGGAGHSTYLLQQLSE KGRLIAFDQDDTALQHAKEVLSDYKGQLILIKSNFRYLKEYLNEQGVTEVDGILFDLG VSSPQLDTPERGFSYHHDAPLDMRMDQSATLSAKEVVNEWRYEDLVRIFFKYGEEKFS KQIARKIEEARMKSPIQTTGQLVDLIKDAIPAPARRSGGHPAKRVFQAIRIAVNDELR VFEEALEQAIEVLKPGGRVSVITFHSLEDRICKTTFKEKSSLPELPPGLPVIPEEFEP ELKLITRKPITASQEELEENNRARSAKLRIAEKRK*" /label="rsmH CDS" gene 1461817..1462752 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /label="rsmH gene" S_feature complement(1462419..1463871) /Source="Nicolas_S_feature" /locus_tag="new_1581224_1582676_c" /HighExp="Salt, Sw, B60, Etha, M9-stat, Gly, C30, LPhT, BC, B36" /AntisenseName="ftsL" /AntisenseCor="-0.195961042435877" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S555" CDS 1462792..1463145 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein" /protein_id="NP_389398.1" /db_xref="EnsemblGenomes-Gn:BSU15150" /db_xref="EnsemblGenomes-Tr:CAB13388" /db_xref="GOA:Q07867" /db_xref="InterPro:IPR011922" /db_xref="SubtiList:BG10220" /db_xref="UniProtKB/Swiss-Prot:Q07867" /translation="MSNLAYQPEKQQRHAISPEKKVIVKKRASITLGEKVLLVLFAAA VLSVSLLIVSKAYAAYQTNIEVQKLEEQISSENKQIGDLEKSVADLSKPQRIMDIAKK NGLNLKDKKVKNIQE*" /label="ftsL CDS" gene 1462792..1463145 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /label="ftsL gene" CDS 1463142..1465292 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8636036, 10411726, 12682299, 14731276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636036, 10411726, 12682299, 14731276; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2B" /protein_id="NP_389399.2" /db_xref="EnsemblGenomes-Gn:BSU15160" /db_xref="EnsemblGenomes-Tr:CAB13389" /db_xref="GOA:Q07868" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10221" /db_xref="UniProtKB/Swiss-Prot:Q07868" /translation="MIQMPKKNKFMNRGAAILSICFALFFFVILGRMAYIQITGKANG EVLATKATEQHEKKRTIEASRGSILDRKGKVIAEDTATYKLIAILDKKMTTDVKHPQH VVNKEKTAEALSKVINLDKADILDILNKDAKQVEFGSAGRDITYSQKQKIEKMKLPGI SFLRDTKRYYPNGVFASNLIGYAEVDEETNEISGAMGLEKVLDKYLKERDGYVTYESD KSGWELPNSKNKITAPKNGDNVYLTIDQKIQTFLEDSMTKVAQKYNPKKIMAAVVDPK TGKVLAMGQRPSFDPNKRDVTNYYNDLISYAYEPGSTMKIFTLAAAMQENVFNANEKY KSGTFEVGGAPVKDHNNGVGWGPTTYHDGVLRSSNVAFAKLAKEKLGYDRLNQYLHKF NFYQKTGIDLPGEVSSKINFKYEFDKASTAYGQASAVTPIQQIQAATAIANDGKMMKP YVIDHIVDPDKDKTIYQNKPESAGTPISASTAKKVRDILGEVVTSKIGTGQAYKIEGF DVAGKTGTAQIAGKGGYLDGTDNYIFSFMGMAPKDDPELLIYVAVQQPQLKAGQSSSD PVSEIFNPTMKNSLHYLNIEPTEKSDSDKEETKAQTMPDLTDQTVAAAQKKAKEENLT PIVIGSDVAVKEQYPKADEEVLTNQKVFLKTGGKIKMPDMTGWSRREVLQYGELAGIH IEVSGQGYAVSQSVKKDKEIKDKTVIKVKFKNPD*" /label="pbpB CDS" gene 1463142..1465292 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /label="pbpB gene" promotor_-10 complement(1463852..1463870) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1463871) /Source="Nicolas_upshifts" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1463885..1463891) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1465275 /Source="Nicolas_upshifts" /id="D861" /incds=0 /nref=237 /ntot=257 /MaxReadThrough="1.141" /MaxDrop="6.28059" /score="3.41058446" /energy="-7.4" /TU="NA" /idTUdmin="U1263" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1465347..1465352 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-35" promotor_-10 1465368..1465386 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-10" upshifts 1465368 /Source="Nicolas_upshifts" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="upshifts" CDS 1465409..1467349 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8244929, 8289242, 9006059, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8244929, 8289242, 9006059, 28383125; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transpeptidase penicillin-binding protein" /protein_id="NP_389400.2" /db_xref="EnsemblGenomes-Gn:BSU15170" /db_xref="EnsemblGenomes-Tr:CAB13390" /db_xref="GOA:Q03524" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR011927" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10222" /db_xref="UniProtKB/Swiss-Prot:Q03524" /translation="MRVSNVTVRKRLLFVLLFGVIVFLIIDTRLGYVQFVMGEKLTSL AKDSWSRNLPFEPERGEILDRNGVKLATNKSAPTVFVVPRQVQNPMKTSKQLAAVLNM SEEKVYKHVTKKASIEKITPEGRKISNEKAKEIKALDLKGVYVAEDSIRHYPFGSFLS HVLGFAGIDNQGLLGLEAYYDDDLKGEKGSVKFYTDAKGKKMPDEADDYTPPKDGLDM KLTVDSKVQTIMERELDNAEAKYHPDGMIAVAMNPKNGEILGMSSRPDFDPADYQSVD PSVYNRNLPVWSTYEPGSTFKIITLAAALEEQKVNLKRDQFYDKGHAEVDGARLRCWK RGGHGLQTYLEVVQNSCNPGFVELGERLGKEKLFKYIKDFGFGQKTGIDLQGEGTGIL FPLERVGPVEQATTAFGQGVSVTPIQQVAAVSAAVNGGTLYTPYIAKEWIDPVTKKTV KKQSPIAKKQVISEETSKQIRYALESVVAEGTGRNAFVEGYRVGGKTGTAQKVKDGKY LENNHIVSFIGFAPADDPSLVVYVAVDNPKGTIQFGGTVAAPIVGNIMRDSLPELGVK PRKNQIEKKYQWNDTKTIEVPNVVGMSVSDLESLLVNLNVDASGKGSKIVKQSPAAGT KVKEGSKIRVYLTEEDEKEAAD*" /label="spoVD CDS" gene 1465409..1467349 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /label="spoVD gene" promotor_-35 1467145..1467151 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-35" promotor_-10 1467166..1467174 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-10" upshifts 1467172 /Source="Nicolas_upshifts" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="upshifts" downshifts 1467322 /Source="Nicolas_upshifts" /id="D862" /incds=0 /nref=19 /ntot=91 /MaxReadThrough="4.23549" /MaxDrop="4.37308" /score="-3.90592085" /energy="-13.6" /TU="U1265,U1266" /idTUdmin="U1265" /TUdmin="-91" /isTUend="FALSE" /label="downshifts" S_feature 1467367..1467434 /Source="Nicolas_S_feature" /locus_tag="new_1586172_1586239" /HighExp="C30, G180, G135, ferm, MG 15, G150, MG 45, MG-0.1, MG 10, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S556" promotor_-35 1467404..1467408 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1467424..1467443 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" S_feature 1467436..1467524 /Source="Nicolas_S_feature" /locus_tag="new_1586241_1586329" /HighExp="G180, G150, LBGexp, Paraq, G135, Oxctl, C30, dia0, Cold, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S557" upshifts 1467436 /Source="Nicolas_upshifts" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" CDS 1467525..1469009 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /EC_number="6.3.2.13" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8436954, 10520745, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase" /protein_id="NP_389401.1" /db_xref="EnsemblGenomes-Gn:BSU15180" /db_xref="EnsemblGenomes-Tr:CAB13391" /db_xref="GOA:Q03523" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005761" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10223" /db_xref="UniProtKB/Swiss-Prot:Q03523" /translation="MKLTKLLTYLTTEPSVNDSQDPEITSIEMDSREVKKGSLFVCVK GYTVDGHDFAQKAVENGAAAIVAEREVDVNVPVIIVRQSLRALSVLSDAFYGQPTKKL QLIGITGTNGKTSTTHMVDEILKKAGKRTGLIGTMYMKIGDETLPVKNTTPESVTLQK TFKKMNDKHVDTAIMEVSSHALSLGRVHGCDYDIAVFTNLTQDHLDYHKTMDEYRHAK SLLFSQLGGAFNHEHPKRAVLNADDEASAYFEKVTAAHISTYGIKNDADVMAKNISIT AQGTSFDLVTNKGTKHITMSLVGQFNVYNVLAAVATCIAAGIPFEIITEAVEELHGVR GRFELVNQQQEFPVIVDYAHTPDSLENVLETCRDMTEGKLFVVVGCGGDRDKTKRPKM AKIAVELADEPIFTSDNPRSEDPRAILRDMEAGVENAYYHSIANREQAIFFAIANAKK GDVVLIAGKGHETYQQIGNETFDFDDAEVAARAIVELNKNKTNS*" /label="murE CDS" gene 1467525..1469009 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /label="murE gene" S_feature 1469010..1469120 /Source="Nicolas_S_feature" /locus_tag="new_1587815_1587925" /HighExp="G180, G135, G150, C30, Oxctl, dia0, LBGexp, MG 25, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S558" CDS 1469121..1470095 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /EC_number="2.7.8.13" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospho-N-acetylmuramoyl-pentapeptide undecaprenyl phosphate (C55P) transferase" /protein_id="NP_389402.2" /db_xref="EnsemblGenomes-Gn:BSU15190" /db_xref="EnsemblGenomes-Tr:CAB13392" /db_xref="GOA:Q03521" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR003524" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG10224" /db_xref="UniProtKB/Swiss-Prot:Q03521" /translation="MLEQVILFTILMGFLISVLLSPILIPFLRRLKFGQSIREEGPKS HQKKSGTPTMGGVMIILSIIVTTIVMTQKFSEISPEMVLLLFVTLGYGLLGFLDDYIK VVMKRNLGLTSKQKLIGQIIIAVVFYAVYHYYNFATDIRIPGTDLSFDLGWAYFILVL FMLVGGSNAVNLTDGLDGLLSGTAAIAFGAFAILAWNQSQYDVAIFSVAVVGAVLGFL VFNAHPAKVFMGDTGSLALGGAIVTIAILTKLEILLVIIGGVFVIETLSVILQVISFK TTGKRIFKMSPLHHHYELVGWSEWRVVVTFWAAGLLLAVLGIYIEVWL*" /label="mraY CDS" gene 1469121..1470095 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /label="mraY gene" CDS 1470096..1471451 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /EC_number="6.3.2.9" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1765076, 9218784, 10966819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate ligase" /protein_id="NP_389403.1" /db_xref="EnsemblGenomes-Gn:BSU15200" /db_xref="EnsemblGenomes-Tr:CAB13393" /db_xref="GOA:Q03522" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005762" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10225" /db_xref="UniProtKB/Swiss-Prot:Q03522" /translation="MENDQFLQKQHFLILGLAKSGYAAASILHEKGIYVAVNDQKPFE ENEPAQKLSEKGIEVVCGEHPVSLFDQHQITILIKNPGIPYENIMVQEAEKRGIPVWT EIELAYYLTSAKFIGITGSNGKTTTTTLIYEMLKADSQKALIAGNIGTVASEVAYHAD GDEWIVTELSSFQLMGTHAFRPEISLILNVFDAHLDYHHTRENYEKAKQKVYLHQTAS DKAIVNQDDETVVRLAEAGKAEIVPFSVSKTLEQGAYVKDSMIMFNGEAILPLEEVVL PGAHNLENILAAIAVVKTAGASNEAVKKVLTSFTGVKHRLQYVTTVNGRKFYNDSKAT NILATSKALSAFDKPVILLAGGLDRGNGFDDLKPYMKHVKAVLTFGQTAPKLEKLGNE LGIQHVKRVDNVEQAVSAAFALSNEGDVILLSPACASWDQFKTFEERGDMFIDAVHML K*" /label="murD CDS" gene 1470096..1471451 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /label="murD gene" promotor_-35 1471275..1471280 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-35" promotor_-10 1471296..1471314 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-10" upshifts 1471306 /Source="Nicolas_upshifts" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="upshifts" CDS 1471512..1472612 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:2509435, 9622350, 15849754, 16484183, 16850406, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509435, 9622350, 15849754, 16484183, 16850406, 27312048; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="factor for spore cortex peptidoglycan synthesis (stage V sporulation)" /protein_id="NP_389404.1" /db_xref="EnsemblGenomes-Gn:BSU15210" /db_xref="EnsemblGenomes-Tr:CAB13394" /db_xref="GOA:P07373" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR013437" /db_xref="InterPro:IPR013438" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10226" /db_xref="UniProtKB/Swiss-Prot:P07373" /translation="MTTKKTSPDLLLVIITLLLLTIGLIMVYSASAVWADYKFDDSFF FAKRQLLFAGIGVIAMFFIMNVDYWTWRTWSKLLMVICFFLLVLVLIPGVGMVRNGSR SWIGVGAFSIQPSEFMKLAMIAFLAKFLSEKQKNITSFRRGFVPALGIVFSAFLIIMC QPDLGTGTVMVGTCIVMIFVAGARIAHFVFLGLIGLSGFVGLVLSAPYRIKRITSYLN PWEDPLGSGFQIIQSLYAVGPGGLFGMGLGQSRQKFFYLPEPQTDFIFAILSEELGFI GGTLILLLFSVLLWRGIRIALGAPDLYGSFVAVGIISMIAIQVMINIGVVTGLIPVTG ITLPFLSYGGSSLTLMLMAVGVLLNVSRYSRY*" /label="spoVE CDS" gene 1471512..1472612 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /label="spoVE gene" S_feature 1472613..1472734 /Source="Nicolas_S_feature" /locus_tag="new_1591418_1591539" /HighExp="G180, C30, G135, G150, Oxctl, Paraq, LBGexp, dia0, S3, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-" /TUshortPSig="0.569, 1, 0.436" /TUlongSig="NA" /TUlongPSig="NA" /label="S559" CDS 1472735..1473826 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /EC_number="2.4.1.227" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9244290, 11042447, 12538870, 12682299, 12813070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9244290, 11042447, 12538870, 12682299, 12813070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine-N-acetylmuramyl- (pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase" /protein_id="NP_389405.2" /db_xref="EnsemblGenomes-Gn:BSU15220" /db_xref="EnsemblGenomes-Tr:CAB13395" /db_xref="GOA:P37585" /db_xref="InterPro:IPR004276" /db_xref="InterPro:IPR006009" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10227" /db_xref="UniProtKB/Swiss-Prot:P37585" /translation="MRIAISGGGTGGHIYPALAFIKEVQRRHPNVEFLYIGTENGLEK KIVERENIPFRSIEITGFKRKLSFENVKTVMRFLKGVKKSKSYLAEFKPDAVIGTGGY VCGPVVYAAAKMGIPTIVHEQNSLPGITNKFLSKYVNKVAICFEEAKSHFPSEKVVFT GNPRASEVVSIKTGRSLAEFGLSEDKKTVLIFGGSRGAAPINRAVIDMQDVLKTRDYQ VLYITGEVHYEKVMNELKSKGAADNMVTKPFLHQMPEYLKAIDVIVARAGATTIAEIT ALGIPSVLIPSPYVTANHQEVNARSLGQHDAAIVLKETELSGEKLIEALDRIVLNEQT LKEMSERTKSLGVPDAAARLYSVLEELKK*" /label="murG CDS" gene 1472735..1473826 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /label="murG gene" promotor_-35 1473215..1473224 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1473237..1473252 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1473242 /Source="Nicolas_upshifts" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" promotor_no_box 1473248..1473348 /Source="Nicolas_upshift_promotors" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1473308 /Source="Nicolas_upshifts" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1473858..1474769 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /EC_number="1.3.1.98" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11327854, 12682299, 16484183, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylenolpyruvoylglucosamine reductase" /protein_id="NP_389406.1" /db_xref="EnsemblGenomes-Gn:BSU15230" /db_xref="EnsemblGenomes-Tr:CAB13396" /db_xref="GOA:P18579" /db_xref="InterPro:IPR003170" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR011601" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036635" /db_xref="SubtiList:BG10228" /db_xref="UniProtKB/Swiss-Prot:P18579" /translation="MEKVIQELKEREVGKVLANEPLANHTTMKIGGPADVLVIPSSVD AVKDIMDVIKKYDVKWTVIGRGSNLLVLDEGIRGVVIKLGAGLDHLELEGEQVTVGGG YSVVRLATSLSKKGLSGLEFAAGIPGSVGGAVYMNAGAHGSDMSEILVKAHILFEDGT IEWLTNEQMDFSYRTSVLQKKRPGVCLEAVLQLEQKDKESIVQQMQSNKDYRKNTQPY SSPCAGSIFRNPLPNHAGNLVEKAGLKGYQIGGAKISEMHGNFIVNAGGASAKDVLDL IDHVKKTIREKYEIDMHTEVEIIGGNR*" /label="murB CDS" gene 1473858..1474769 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /label="murB gene" downshifts 1474787 /Source="Nicolas_upshifts" /id="D863" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="5.78428" /MaxDrop="2.8642" /score="-7.67573434" /energy="-7.4" /TU="U1267,U1268,U1269,U1270" /idTUdmin="U1266" /TUdmin=1809 /isTUend="FALSE" /label="downshifts" CDS 1474899..1475690 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389407.1" /db_xref="EnsemblGenomes-Gn:BSU15240" /db_xref="EnsemblGenomes-Tr:CAB13397" /db_xref="GOA:P16655" /db_xref="InterPro:IPR005548" /db_xref="InterPro:IPR013685" /db_xref="InterPro:IPR026580" /db_xref="InterPro:IPR034746" /db_xref="SubtiList:BG10229" /db_xref="UniProtKB/Swiss-Prot:P16655" /translation="MNPGQDREKIVNIEERIPKIKEQRKQKANRRLISFIMLFFIMVL IIVYLQTPISKVSTISVTGNENVSKKEIIDLSDINSGDTEFWSLDKQKTEKKIQQNKL VKKAEISKSLPNKINIAIEEYKAIAYLEKDDVYYEVLENGSVLPNEVTPDDAGPILVN WTNAKKRSQMAKQLDALSNSLKQSISEIYYTPVKMDENRIKLYMNDGYVVTASIKTFA DRMKTYPSIISQLSSNKKGIIHLEVATYFEEFGKNDKAAKKEDEN*" /label="divIB CDS" gene 1474899..1475690 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /label="divIB gene" CDS 1475687..1476382 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389408.2" /db_xref="EnsemblGenomes-Gn:BSU15250" /db_xref="EnsemblGenomes-Tr:CAB13398" /db_xref="GOA:C0SPA3" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11490" /db_xref="UniProtKB/Swiss-Prot:C0SPA3" /translation="MRGKSAVLLSLIMLIAGFLISFSFQMTKENNKSAAETEEWKKEY ALRDELLKQEKENKKFEKELYQKQNKVRQAENKLKKEKSEYYNVLEDTEKYRMYIGEV GVQGEGVEVTLEDASYIPEGENVNSYIVHESHIFQVVNELYISGAAAVAVNGQRLTHD SYIKCNGPVVTVDGVQHPAPFTVSAIGDPDVLLPSLNIAGGLIDQLSMDHISVSAEKE KNVQMKPILKTKE*" /label="ylxW CDS" gene 1475687..1476382 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /label="ylxW gene" CDS 1476405..1477112 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183, 18179421" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389409.2" /db_xref="EnsemblGenomes-Gn:BSU15260" /db_xref="EnsemblGenomes-Tr:CAB13399" /db_xref="GOA:Q45544" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11489" /db_xref="UniProtKB/Swiss-Prot:Q45544" /translation="MKIKRSFISISVLMVIFGLMISVQFNSLKHPKVRDTRDMWDIRE ELTSEQKKQEKLLAEINKYDKLLNSYSQTKEMTKETALNNTLQSLKKTAGMTDITGSG IVITISPLFSESLTGEPIENPPPDLLKKLINELNSYGAEHISINERRVVNHTVIRDIN GTTKIDGYALDDYPLTVKVLAKDPDMLHSRVKGSGLEDLFASENLALKAGKSESKLTL KAYDRPLDVQQLKLLKD*" /label="ylxX CDS" gene 1476405..1477112 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /label="ylxX gene" CDS 1477130..1477495 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1569582, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (small basic protein)" /protein_id="NP_389410.1" /db_xref="EnsemblGenomes-Gn:BSU15270" /db_xref="EnsemblGenomes-Tr:CAB13400" /db_xref="GOA:P28265" /db_xref="InterPro:IPR009709" /db_xref="SubtiList:BG10230" /db_xref="UniProtKB/Swiss-Prot:P28265" /translation="MWLPVLGLVLGIAIGLMTNLTIPSEYSNYLSLAVLAALDTLIGG IRAHLQGTYDEMVFVSGFFFNIILAISLAFLGVHLGVDLYLAGIFAFGVRLFQNIAVI RRNLLTKWTLSKKNKKNVI*" /label="sbp CDS" gene 1477130..1477495 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /label="sbp gene" promotor_-35 1477347..1477350 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1477366..1477385 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1477382 /Source="Nicolas_upshifts" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" S_feature 1477496..1477668 /Source="Nicolas_S_feature" /locus_tag="new_1596301_1596473" /HighExp="T3.0H, T2.30H, S2, T3.30H, Lbtran, T4.0H, T5.0H, T1.30H, S1, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigWXY, SigA" /TUshortPSig="0.989, 0.0739, 1, 1" /TUlongSig="SigEF, Sig-" /TUlongPSig="0.569, 0.436" /label="S560" CDS 1477669..1478991 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein essential for Z-ring assembly" /protein_id="NP_389411.2" /db_xref="EnsemblGenomes-Gn:BSU15280" /db_xref="EnsemblGenomes-Tr:CAB13401" /db_xref="GOA:P28264" /db_xref="InterPro:IPR003494" /db_xref="InterPro:IPR020823" /db_xref="SubtiList:BG10231" /db_xref="UniProtKB/Swiss-Prot:P28264" /translation="MNNNELYVSLDIGTSNTKVIVGEMTDDSLNIIGVGNVPSEGLKK GSIVDIDETVHSIRKAFDQAERMVGFPLRKAIVGVNGNYINIQDTNGVVAVSSENKEI QVEDVRRVMEAAQVVSVPHEQLIVDVIPKQFIVDGRDEITDPKKMLGVRLEVEGTLIT GSKTILHNLLRCVERAGIEITDICLQPLAAGSAALSKDEKNLGVALIDIGGGSTTIAV FQNGHLTSTRVIPLGGENITKDISIGLRTSTEEAERVKKQLGHAYYDEASEDEIFEVT VIGTNQKQTFTQQEAANIIEARVEEILEIVSEELRSMGITDLPGGFVLTGGQAAMPGV MSLAQDVLQNNVRVASPNYIGVRDPQYMTGVGLIQFACRNARIQGRKIGFKMPEEAIQ EIAVSSSEEQEQHHHQNEVQQRPKGKQKTQAEHNKQSKMKKLLSMFWE*" /label="ftsA CDS" gene 1477669..1478991 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /label="ftsA gene" upshifts complement(1477876) /Source="Nicolas_upshifts" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1477880..1477884) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1477899..1477903) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1479027..1480175 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389412.2" /db_xref="EnsemblGenomes-Gn:BSU15290" /db_xref="EnsemblGenomes-Tr:CAB13402" /db_xref="GOA:P17865" /db_xref="InterPro:IPR000158" /db_xref="InterPro:IPR003008" /db_xref="InterPro:IPR008280" /db_xref="InterPro:IPR018316" /db_xref="InterPro:IPR020805" /db_xref="InterPro:IPR024757" /db_xref="InterPro:IPR036525" /db_xref="InterPro:IPR037103" /db_xref="PDB:2RHH" /db_xref="PDB:2RHJ" /db_xref="PDB:2RHL" /db_xref="PDB:2RHO" /db_xref="PDB:2VAM" /db_xref="PDB:2VXY" /db_xref="PDB:4U39" /db_xref="SubtiList:BG10232" /db_xref="UniProtKB/Swiss-Prot:P17865" /translation="MLEFETNIDGLASIKVIGVGGGGNNAVNRMIENEVQGVEYIAVN TDAQALNLSKAEVKMQIGAKLTRGLGAGANPEVGKKAAEESKEQIEEALKGADMVFVT AGMGGGTGTGAAPVIAQIAKDLGALTVGVVTRPFTFEGRKRQLQAAGGISAMKEAVDT LIVIPNDRILEIVDKNTPMLEAFREADNVLRQGVQGISDLIATPGLINLDFADVKTIM SNKGSALMGIGIATGENRAAEAAKKAISSPLLEAAIDGAQGVLMNITGGTNLSLYEVQ EAADIVASASDQDVNMIFGSVINENLKDEIVVTVIATGFIEQEKDVTKPQRPSLNQSI KTHNQSVPKREPKREEPQQQNTVSRHTSQPADDTLDIPTFLRNRNKRG*" /label="ftsZ CDS" gene 1479027..1480175 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /label="ftsZ gene" downshifts 1480149 /Source="Nicolas_upshifts" /id="D864" /incds=0 /nref=226 /ntot=389 /MaxReadThrough="2.85051" /MaxDrop="7.70428" /score="34.7919519" /energy="-13.7" /TU="U1267,U1271" /idTUdmin="U1269" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" SCAR join(1480270,1480277) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs20" N_region 1480271..1480276 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs20" S_feature <1480277..1480322 /Source="Nicolas_S_feature" /locus_tag="new_1606413_1606501" /HighExp="LoTm, S7, S8, BT, S6, S4, G/S, S3, S2, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S565" promotor_-35 1480287..1480294 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1480307..1480326 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1480324 /Source="Nicolas_upshifts" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1480381..1481175 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683, 18083814; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389417.2" /db_xref="EnsemblGenomes-Gn:BSU15340" /db_xref="EnsemblGenomes-Tr:CAB13408" /db_xref="GOA:O31723" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13370" /db_xref="UniProtKB/Swiss-Prot:O31723" /translation="MILQLDNVSLKRNGKWILKDIHWKVEEKENWVLYGLNGAGKTAL LNMLCSYYFPTSGEMQVLGHEFGKTELGEKLRRKIGLVSAALQQKLYPADSAFEIALS GAYASIGLYETPSKETREKAIGLLEDLGAIEYADRRYETLSQGEKQRALIARALMADP ELLILDEPVTGLDFIAREKLLDTITYIANKENAPSILYVTHHAEEILPVFDKALLLKQ GEVFGSGEIKEMLTDQILSAFFDTPIHVLWNQDRPFLTRAEPITNA*" /label="ylmA CDS" gene 1480381..1481175 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /label="ylmA gene" promotor_-35 1481093..1481096 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-35" promotor_-10 1481111..1481130 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-10" upshifts 1481119 /Source="Nicolas_upshifts" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="upshifts" misc_RNA 1481188..1481289 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswE RNA" gene 1481188..1481289 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /label="tswE gene" downshifts 1481276 /Source="Nicolas_upshifts" /id="D867" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="5.58534" /MaxDrop="4.3688" /score="-2.39598083" /energy="-7.1" /TU="U1278,U1279" /idTUdmin="U1274" /TUdmin=971 /isTUend="FALSE" /label="downshifts" CDS 1481377..1482657 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /EC_number="3.5.1.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17618314" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17618314; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-4-amino-5-aminomethyl-2- methylpyrimidinedeformylase" /protein_id="NP_389418.2" /db_xref="EnsemblGenomes-Gn:BSU15350" /db_xref="EnsemblGenomes-Tr:CAB13409" /db_xref="GOA:O31724" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13371" /db_xref="UniProtKB/Swiss-Prot:O31724" /translation="MDQQIYSLQKKVEEHKEELIQLAKTLISYQTPAPPARNTEGIQS WIAGYLNELGFSIDKWDVYPGDPNVVGKLKGTDSADYYSLIINGHVDVAEVKEDEEWK HDPFHPIEKNGLLIGRGASDMKGGMACVLFAVKLIREASIELPGDLILQSVIGEEVGE AGTLECCKRGYHADFAIVADTSDMHIQGQGGVITGWIEIKSSQTFHDGTRRNMIHAGG GTFGASAIEKMAKIIAGLGELERHWSIMKSYPGFKPGTNTINPAVIEGGRHAAFIADE CRLWITVHFYPNETHDQVAAEIEDYVNRLSDSDIWLRENRPVFKWGGSSMIEDRGEIF PALEVDPGHPGVLALTASHQKVKRECPIIDVSQSVTDGGWLYDAGIPCVIYGPGDLHN AHSVNEKVSIEQLVEYTKIILDFIISWCSRKKEQ*" /label="thiQ CDS" gene 1481377..1482657 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /label="thiQ gene" misc_feature complement(1482598..1482614) /Source="Nicolas_upshift_promotors" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1482603) /Source="Nicolas_upshifts" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1482678..1482683 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-35" promotor_-10 1482699..1482717 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-10" upshifts 1482703 /Source="Nicolas_upshifts" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="upshifts" CDS 1482740..1482985 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /experiment="publication(s) with functional evidences, PMID:12429060, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12429060, 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="essential sporulation protein" /protein_id="NP_389419.1" /db_xref="EnsemblGenomes-Gn:BSU15360" /db_xref="EnsemblGenomes-Tr:CAB13410" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13372" /db_xref="UniProtKB/Swiss-Prot:O31725" /translation="MISISEFQVKDVVNVSNGKKLGSIGDIDINVTTGKIQAIILGGN GKVLGFFGKEEELVIPWRNIVKIGEDVILVRLSEPHA*" /label="ylmC CDS" gene 1482740..1482985 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /label="ylmC gene" promotor_-35 1482901..1482909 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1482920..1482938 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1482928 /Source="Nicolas_upshifts" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1482986..1483096 /Source="Nicolas_S_feature" /locus_tag="new_1609165_1609275" /HighExp="T3.0H, S2, S1, T4.0H, T3.30H, T5.0H, T2.0H, BC, Gly, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34150000000000003" /TUshortSig="SigH, SigEF, SigA, SigA" /TUshortPSig="1, 0.998, 0.976, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S566" misc_feature 1483088..1483107 /Source="Nicolas_upshift_promotors" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1483098 /Source="Nicolas_upshifts" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1483148..1483984 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16498617, 19737354; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved protein with laccase domain" /protein_id="NP_389420.1" /db_xref="EnsemblGenomes-Gn:BSU15370" /db_xref="EnsemblGenomes-Tr:CAB13411" /db_xref="GOA:O31726" /db_xref="InterPro:IPR003730" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG13373" /db_xref="UniProtKB/Swiss-Prot:O31726" /translation="MNTYHPFSLTTPSTLMIQDWAQTNQNNKEVIAGFTTKNGGVSQK PFESLNTGLHVHDKDADVVKNREYIADMFNTDLQSWVFADQTHDNRVQKVTQRDRGKG AREYHTALKATDGIYTNEKNVFLALCFADCVPLFFYDPVKSLVGVAHAGWKGTVKQIG REMVKQWTEKEGSNPSDIYAVIGPSISGACYTVDDRVMDAVRALPVSADLAANQTAKA QYQLDLKELNRLILMDSGLASEQISVSGLCTESEPSLFYSHRRDQGKTGRMMSFIGMK EA*" /label="ylmD CDS" gene 1483148..1483984 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /label="ylmD gene" CDS 1483991..1484683 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14526035, 24097949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PLP-containing enzyme" /protein_id="NP_389421.1" /db_xref="EnsemblGenomes-Gn:BSU15380" /db_xref="EnsemblGenomes-Tr:CAB13412" /db_xref="GOA:O31727" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR011078" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG13374" /db_xref="UniProtKB/Swiss-Prot:O31727" /translation="MRVVDNLRHINERINEACNRSGRSSDEVTVIAVTKYVSPERAQE AVDAGITCLGENRDAELLRKQELMKGNPEWHFIGSLQSRKAKSVVNSVSYIHSLDRLS LAKEIEKRAEGTVRCFVQVNTSLEPSKHGMKKEEVIPFIQELSGFEHILVAGLMTMAP LTDDQDQIRSCFRSLRELRDQVQKLNQPNAPCTELSMGMSNDFEIAIEEGATYIRIGS SLVGNETGGVQQ*" /label="ylmE CDS" gene 1483991..1484683 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /label="ylmE gene" CDS 1484680..1485135 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14526035, 16420366, 16796675, 18782755, 22912848, 24218584" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526035, 16420366, 16796675, 18782755, 22912848, 24218584; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division machinery factor" /protein_id="NP_389422.3" /db_xref="EnsemblGenomes-Gn:BSU15390" /db_xref="EnsemblGenomes-Tr:CAB13413" /db_xref="GOA:O31728" /db_xref="InterPro:IPR007561" /db_xref="InterPro:IPR023052" /db_xref="PDB:3ZIH" /db_xref="PDB:3ZII" /db_xref="SubtiList:BG13375" /db_xref="UniProtKB/Swiss-Prot:O31728" /translation="MSMKNKLKNFFSMEDEEYEYEYIETERESHEEHEQKEKPAYNGN KPAGKQNVVSLQSVQKSSKVVLSEPRVYAEAQEIADHLKNRRAVVVNLQRIQHDQAKR IVDFLSGTVYAIGGDIQRIGSDIFLCTPDNVDVSGTISELISEDEHQRW*" /label="sepF CDS" gene 1484680..1485135 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /label="sepF gene" CDS 1485142..1485414 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14526035, 19966467, 20359373; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, distribution of nucleoids and osmotic tolerance" /protein_id="NP_389423.1" /db_xref="EnsemblGenomes-Gn:BSU15400" /db_xref="EnsemblGenomes-Tr:CAB13414" /db_xref="GOA:O31729" /db_xref="InterPro:IPR003425" /db_xref="SubtiList:BG13376" /db_xref="UniProtKB/Swiss-Prot:O31729" /translation="MILYQVFSVLSLLITIYSFALIIYIFMSWVPSTRETAVGRFLAS ICEPYLEPFRKIIPPIAMLDISPIVAILVLRFATTGLWGLYRMIAF*" /label="ylmG CDS" gene 1485142..1485414 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /label="ylmG gene" downshifts 1485403 /Source="Nicolas_upshifts" /id="D868" /incds=0 /nref=16 /ntot=97 /MaxReadThrough="6.19839" /MaxDrop="4.93537" /score="-6.17078585" /energy="-15.2" /TU="U1278,U1281,U1282,U1283" /idTUdmin="U1281" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" CDS 1485475..1486248 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10093218, 14526035, 21141807; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, RNA-binding fold" /protein_id="NP_389424.1" /db_xref="EnsemblGenomes-Gn:BSU15410" /db_xref="EnsemblGenomes-Tr:CAB13415" /db_xref="GOA:P71020" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11856" /db_xref="UniProtKB/Swiss-Prot:P71020" /translation="MSDIYQHFRKDERAFIDQALEWKRIVQEQYRMKLTDFLDPREQV ILSAVTGQADVGLAFSGGYDRAERKRAILFPEYITPEESDFELQAFNVRYADKFVSVD HRSLLGALMGIGLKRQKFGDIVFSETAVQLIVSADTADFVAAQLTQAGKAAVSLEKID LSDLNIPAVDVEIRDDTVSSLRLDAVCASMSRQSRQKSQTLVKNGLVKVNWKVVEDPS YIVAEGDMLSIRGFGRCSLTKIEGKTKKDKWRVTFERQK*" /label="ylmH CDS" gene 1485475..1486248 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /label="ylmH gene" promotor_-35 1485964..1485971 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1485985..1486003 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1486008 /Source="Nicolas_upshifts" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1486249..1486341 /Source="Nicolas_S_feature" /locus_tag="new_1612428_1612520" /HighExp="C90, M0t90, C30, GM-0.1, Glucon, MG 5, GM 45, GM 5, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigH, SigEF, SigA" /TUshortPSig="0.973, 1, 1, 0.998, 0.989" /TUlongSig="SigA" /TUlongPSig="0.976" /label="S567" CDS 1486342..1486836 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389425.1" /db_xref="EnsemblGenomes-Gn:BSU15420" /db_xref="EnsemblGenomes-Tr:CAB13416" /db_xref="GOA:P71021" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR019933" /db_xref="PDB:2WUJ" /db_xref="PDB:2WUK" /db_xref="SubtiList:BG11835" /db_xref="UniProtKB/Swiss-Prot:P71021" /translation="MPLTPNDIHNKTFTKSFRGYDEDEVNEFLAQVRKDYEIVLRKKT ELEAKVNELDERIGHFANIEETLNKSILVAQEAAEDVKRNSQKEAKLIVREAEKNADR IINESLSKSRKIAMEIEELKKQSKVFRTRFQMLIEAQLDLLKNDDWDHLLEYEVDAVF EEKE*" /label="divIVA CDS" gene 1486342..1486836 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /label="divIVA gene" promotor_-35 1486849..1486856 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1486870..1486889 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1486877 /Source="Nicolas_upshifts" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1486899..1487125 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /product="T-box riboswitch specific of isoleucine tRNA" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /label="iswA RNA" gene 1486899..1487125 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /label="iswA gene" downshifts 1487092 /Source="Nicolas_upshifts" /id="D869" /incds=0 /nref=43 /ntot=100 /MaxReadThrough="7.76706" /MaxDrop="5.97038" /score="48.8352635" /energy="-19.4" /TU="U1278,U1282,U1283,U1284,U1285" /idTUdmin="U1281" /TUdmin=237 /isTUend="FALSE" /label="downshifts" CDS 1487178..1489943 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /EC_number="6.1.1.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16697013, 17043414, 17095543, 28139725; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucyl-tRNA synthetase" /protein_id="NP_389426.2" /db_xref="EnsemblGenomes-Gn:BSU15430" /db_xref="EnsemblGenomes-Tr:CAB13417" /db_xref="GOA:Q45477" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002301" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023585" /db_xref="InterPro:IPR033708" /db_xref="SubtiList:BG11792" /db_xref="UniProtKB/Swiss-Prot:Q45477" /translation="MDFKDTLLMPKTDFPMRGNLPNREPDIQKKWEEEDIYRLVQERT KDRPKFVLHDGPPYANGDIHMGHALNKILKDFIVRYKSMSGYNAPYVPGWDTHGLPIE TALTKNKKVNRKEMSVAEFRKLCEEYAWKQIEGQREQFKRLGVRGDWENPYVTLKPEY EAQQIRVFGEMAKRGYIYKGLKPVNWSPSSESALAEAEIEYQDKRSASIYVAFGVKDG KGVLENGERIIIWTTTPWTIPANLGISVHPDLEYSVIAVGEDRFVVASALVENVASAC GFDQYEVTRTVKGKDLENIIAEHPLYGRDSLVMLGEHVTTDAGTGCVHTAPGHGEDDF IIGQKYGLDVLCPVDEKGVMTSEAPGFEGMFYDDANKAITQQLDEKGALVKLEFITHS YPHDWRTKKPTIFRATAQWFASIKDFRSDLLDAIKETKWVPEWGEQRLHNMVRDRGDW CISRQRAWGVPIPVFYAENGEPVITDETIEHVSELFRQHGSNIWFEKEAKDLLPEGFT HPGSPNGTFTKEQDIMDVWFDSGSSHQAVLEERDDLVRPADLYLEGSDQYRGWFNSSL STAVAVTGKAPYKGVLSHGFALDGEGRKMSKSIGNVVVPAKVMKQLGADILRLWVSSV DYQADVRVSDAILKQVAEVYRKIRNTFRFLHGNLFDFDPKTNAVAVEDLREVDQYMLI KLNKLIDKVKKAYDEYEFAVVYHSIHNFCTIELSSFYLDFAKDIVYIEHADHPDRRSM QTVFYETLLALVKLSAPILPHTADELWSHLTFVEEQSVQLTDMPETITVPNSEATEEK FDRFMALRDDVLKALETARNEKIIGKSLEANLKLYPNKENKELLASIKENLSQLFIVS ELTISEENEAPNDAQSFATGKIAVEKAEGEMCERSRVISKDVGANPKYPTLSLRNAEI VEKYYQK*" /label="ileS CDS" gene 1487178..1489943 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /label="ileS gene" downshifts 1489934 /Source="Nicolas_upshifts" /id="D870" /incds=0 /nref=233 /ntot=261 /MaxReadThrough="2.6695" /MaxDrop="6.91924" /score="40.2175565" /energy="-13.9" /TU="NA" /idTUdmin="U1278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(1489989) /Source="Nicolas_upshifts" /id="D871" /incds=0 /nref=6 /ntot=17 /MaxReadThrough="1.29709" /MaxDrop="3.66645" /score="13.8608728" /energy="-15.6" /TU="NA" /idTUdmin="U1275" /TUdmin="-12534" /isTUend="FALSE" /label="downshifts" promotor_-35 1490024..1490030 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-35" promotor_-10 1490045..1490056 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-10" upshifts 1490045 /Source="Nicolas_upshifts" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="upshifts" CDS 1490088..1490462 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15496987, 23123912, 23678950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15496987, 23123912, 23678950; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related RNA polymerase-binding factor" /protein_id="NP_389427.2" /db_xref="EnsemblGenomes-Gn:BSU15440" /db_xref="EnsemblGenomes-Tr:CAB13418" /db_xref="GOA:Q45478" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR016841" /db_xref="InterPro:IPR020458" /db_xref="SubtiList:BG11795" /db_xref="UniProtKB/Swiss-Prot:Q45478" /translation="MNDQLTAIYTELLLMKEELQSRLFEYSCFQVSTSPQAAINQKQK ATLIYHIKEELQDVLLALSKIENGTFGYCEETGAPIPLAKLAVLPTARTANDFLYSVQ FEKKTLPIWKSTDIEYGQALYE*" /label="ylyA CDS" gene 1490088..1490462 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /label="ylyA gene" promotor_-35 1490494..1490498 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" upshifts 1490513 /Source="Nicolas_upshifts" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" promotor_-10 1490514..1490533 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" CDS 1490565..1491029 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /EC_number="3.4.23.36" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9880550, 9882689, 10497172, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880550, 9882689, 10497172, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="signal peptidase II" /protein_id="NP_389428.1" /db_xref="EnsemblGenomes-Gn:BSU15450" /db_xref="EnsemblGenomes-Tr:CAB13419" /db_xref="GOA:Q45479" /db_xref="InterPro:IPR001872" /db_xref="SubtiList:BG11793" /db_xref="UniProtKB/Swiss-Prot:Q45479" /translation="MLYYMIALLIIAADQLTKWLVVKNMELGQSIPIIDQVFYITSHR NTGAAWGILAGQMWFFYLITTAVIIGIVYYIQRYTKGQRLLGVALGLMLGGAIGNFID RAVRQEVVDFIHVIIVNYNYPIFNIADSSLCVGVMLLFIQMLLDSGKKKKEQ*" /label="lspA CDS" gene 1490565..1491029 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /label="lspA gene" CDS 1491031..1491942 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15078091, 15928344, 17188032, 17937767, 18032607, 20817755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389429.3" /db_xref="EnsemblGenomes-Gn:BSU15460" /db_xref="EnsemblGenomes-Tr:CAB13420" /db_xref="GOA:Q45480" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11796" /db_xref="UniProtKB/Swiss-Prot:Q45480" /translation="MNQIDITASEEQKSERIDKFLASTENDWSRTQVQQWVKDGQVVV NGSAVKANYKIQPGDQVTVTVPEPEALDVLAEPMDLDIYYEDQDVLVVNKPRGMVVHP APGHLTGTLVNGLMAHCTDLSGINGVMRPGIVHRIDKDTSGLLMVAKNDMAHESLVNQ LVNKTVTRKYTAVVHGLISHDDGTIDAPIGRDKKDRQSMTVTRDGKNAVTHFHVLERF QDFTLVECQLETGRTHQIRVHMKYIGFPLAGDPKYGPRKTIDFNGQALHAGVLGFDHP RTGEYVEFEAPLPEDMAELIENLRKNG*" /label="rluD CDS" gene 1491031..1491942 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /label="rluD gene" promotor_-35 1491937..1491944 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" promotor_-10 1491959..1491978 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" upshifts 1491973 /Source="Nicolas_upshifts" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" misc_RNA 1491982..1492098 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaA RNA" gene 1491982..1492098 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /label="pyaA gene" CDS 1492125..1492670 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /EC_number="2.4.2.9" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7798145, 9932459, 12482852, 15716449, 17322189, 18678934" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 9932459, 12482852, 15716449, 17322189, 18678934; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional attenuator and uracil phosphoribosyltransferase activity" /protein_id="NP_389430.1" /db_xref="EnsemblGenomes-Gn:BSU15470" /db_xref="EnsemblGenomes-Tr:CAB13421" /db_xref="GOA:P39765" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR023050" /db_xref="InterPro:IPR029057" /db_xref="PDB:1A3C" /db_xref="PDB:1A4X" /db_xref="PDB:4P82" /db_xref="SubtiList:BG10712" /db_xref="UniProtKB/Swiss-Prot:P39765" /translation="MNQKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGI YLAKRLAERIEQIEGNPVTVGEIDITLYRDDLSKKTSNDEPLVKGADIPVDITDQKVI LVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSE KVMVQLDEVDQNDLVAIYENE*" /label="pyrR CDS" gene 1492125..1492670 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /label="pyrR gene" downshifts complement(1492319) /Source="Nicolas_upshifts" /id="D872" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="1.85132" /MaxDrop="2.50006" /score="0.812637138" /energy="-7" /TU="NA" /idTUdmin="U1275" /TUdmin="-14864" /isTUend="FALSE" /label="downshifts" downshifts 1492661 /Source="Nicolas_upshifts" /id="D873" /incds=0 /nref=13 /ntot=149 /MaxReadThrough="8.16191" /MaxDrop="3.4492" /score="16.3570883" /energy="-11.5" /TU="U1287,U1288" /idTUdmin="U1286" /TUdmin=704 /isTUend="FALSE" /label="downshifts" misc_RNA 1492674..1492791 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaB RNA" gene 1492674..1492791 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /label="pyaB gene" CDS 1492844..1494151 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8206848, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uracil permease" /protein_id="NP_389431.2" /db_xref="EnsemblGenomes-Gn:BSU15480" /db_xref="EnsemblGenomes-Tr:CAB13422" /db_xref="GOA:P39766" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR029935" /db_xref="SubtiList:BG10992" /db_xref="UniProtKB/Swiss-Prot:P39766" /translation="MSKKKVNLGVRDVPTPFSWVSFSLQHLFAMFGSTILVPKLVGMS PAVALVTSGIGTLAYLLITKGQIPAYLGSSFAFISPIILVKATGGPGAAMVGAFLAGL VYGLIALLIRQLGTGWLMKILPPVVVGPVIIVIGLGLASTAVNMAMYADPNASELVYS LKHFSVAGVTLAITIICAIFLRGFLSLIPVLIGIIGGYLFALTQGIVNFQPVLDAKWF AVPEFIIPFKDYSPSVTLGIAAAMVPVAFVTMSEHIGHQMVLSKVVGQDFIKKPGLHR SIMGDSVATILASLIGGPPTTTYGENIGVLAITRVFSVFVIGGAAVIALCFGFIGKIS ALISSVPSAVMGGVSFLLFGIIASSGLRMLIDNKIDYENNRNLIITSVILVIGVGGAF IQVSQGGFQVSGMALAAIVGVILNLILPQAKEEQADTSEQHHI*" /label="pyrP CDS" gene 1492844..1494151 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /label="pyrP gene" misc_RNA 1494152..1494266 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaC RNA" gene 1494152..1494266 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /label="pyaC gene" CDS 1494297..1495211 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /EC_number="2.1.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8535162, 16321950, 21663747" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8535162, 16321950, 21663747; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate carbamoyltransferase" /protein_id="NP_389432.2" /db_xref="EnsemblGenomes-Gn:BSU15490" /db_xref="EnsemblGenomes-Tr:CAB13423" /db_xref="GOA:P05654" /db_xref="InterPro:IPR002082" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR036901" /db_xref="PDB:2AT2" /db_xref="PDB:3R7D" /db_xref="PDB:3R7F" /db_xref="PDB:3R7L" /db_xref="SubtiList:BG10713" /db_xref="UniProtKB/Swiss-Prot:P05654" /translation="MKHLTTMSELSTEEIKDLLQTAQELKSGKTDNQLTGKFAANLFF EPSTRTRFSFEVAEKKLGMNVLNLDGTSTSVQKGETLYDTIRTLESIGVDVCVIRHSE DEYYEELVSQVNIPILNAGDGCGQHPTQSLLDLMTIYEEFNTFKGLTVSIHGDIKHSR VARSNAEVLTRLGARVLFSGPSEWQDEENTFGTYVSMDEAVESSDVVMLLRIQNERHQ SAVSQEGYLNKYGLTVERAERMKRHAIIMHPAPVNRGVEIDDSLVESEKSRIFKQMKN GVFIRMAVIQRALQTNVKRGEAAYVISH*" /label="pyrB CDS" gene 1494297..1495211 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /label="pyrB gene" CDS 1495195..1496481 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /EC_number="3.5.2.3" /function="2: Purines, pyrimidines, nucleosides, and nucleotides" /experiment="publication(s) with functional evidences, PMID:7516791, 16522191, 21045288" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7516791, 16522191, 21045288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotase" /protein_id="NP_389433.2" /db_xref="EnsemblGenomes-Gn:BSU15500" /db_xref="EnsemblGenomes-Tr:CAB13424" /db_xref="GOA:P25995" /db_xref="InterPro:IPR002195" /db_xref="InterPro:IPR004722" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10714" /db_xref="UniProtKB/Swiss-Prot:P25995" /translation="MSYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVI DAKGLLVSPGFVDLHVHFREPGGEKKETIETGAKAAARGGYTTVAAMPNTRPVPDTKE QMEWVQNRIKETSCVRVLPYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGM MYEAMKRAAAIDKAIVAHCEDNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVL LAEAANCHYHVCHISTKESVRVVRDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKM NPPLRSPEDRAALIEGLLDGTIDFIATDHAPHTEEEKNTEMKLAPFGIVGLETAFPLL YTHFVKNGSWSLKQLIDYMTIKPCEAFGLPYGTLQTGQAADITLIDLEKEAVIDKETF LSKGKNTPFNGISCTGWPVATIAAGKLAYEEGRLVK*" /label="pyrC CDS" gene 1495195..1496481 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /label="pyrC gene" CDS 1496478..1497572 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1709162, 11390694, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit)" /protein_id="NP_389434.1" /db_xref="EnsemblGenomes-Gn:BSU15510" /db_xref="EnsemblGenomes-Tr:CAB13425" /db_xref="GOA:P25993" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10715" /db_xref="UniProtKB/Swiss-Prot:P25993" /translation="MKRRLVLENGAVFEGEAFGSLEHNMGEVVFNTGMTGYQEILSDP SYCGQIVTLTYPLIGNYGINRDDFESITPFVKGLIIKELCELPSNWRSAYTLDEYLKM KNIPGLQGIDTRKLTRMIRTAGALKGTFASSDEDIEAVLKRLNETELPRNQVSQVSAK TAYPSPGRGKRIVLVDFGMKHGILRELNKRKCDVIVVPYNITAEEVLQLKPDGIMLSN GPGDPKDVPEAIEMIKGVLGKVPLFGICLGHQLFALACGANTEKMKFGHRGSNHPVKE LATGKVALTSQNHGYTVSSISKTELEVTHIAINDDTIEGLKHKTLPAFTVQYHPEASP GPEDANHLFDRFIEMIETTEKEGEAVCQNA*" /label="pyrAA CDS" gene 1496478..1497572 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /label="pyrAA gene" CDS 1497557..1500772 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 216664, 6120161, 10732707, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (large subunit)" /protein_id="NP_389435.1" /db_xref="EnsemblGenomes-Gn:BSU15520" /db_xref="EnsemblGenomes-Tr:CAB13426" /db_xref="GOA:P25994" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR033937" /db_xref="InterPro:IPR036897" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10716" /db_xref="UniProtKB/Swiss-Prot:P25994" /translation="MPKRVDINKILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYEV ILVNSNPATIMTDTEMADRVYIEPLTPEFLTRIIRKERPDAILPTLGGQTGLNLAVEL SERGVLAECGVEVLGTKLSAIQQAEDRDLFRTLMNELNEPVPESEIIHSLEEAEKFVS QIGFPVIVRPAYTLGGTGGGICSNETELKEIVENGLKLSPVHQCLLEKSIAGYKEIEY EVMRDSQDHAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDREYQLLRNVSLKLIRALG IEGGCNVQLALDPDSFQYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLSLDEM MNPVTGKTYAAFEPALDYVVSKIPRWPFDKFESANRKLGTQMKATGEVMAIGRTLEES LLKAVRSLEADVYHLELKDAADISDELLEKRIKKAGDERLFYLAEAYRRGYTVEDLHE FSAIDVFFLHKLFGIVQFEKELKANAGDTDVLRRAKELGFSDQYISREWKMKESELYS LRKQAGIAPVFKMVDTCAAEFESETPYFYSTYEEENESVVTDKKSVMVLGSGPIRIGQ GVEFDYATVHSVWAIKQAGYEAIIVNNNPETVSTDFSISDKLYFEPLTIEDVMHIIDL EQPMGVVVQFGGQTAINLADELSARGVKILGTSLEDLDRAEDRDKFEQALGELGVPQP LGKTATSVNQAVSIASDIGYPVLVRPSYVLGGRAMEIVYHEEELLHYMKNAVKINPQH PVLIDRYLTGKEIEVDAVSDGETVVIPGIMEHIERAGVHSGDSIAVYPPQSLTEDIKK KIEQYTIALAKGLNIVGLLNIQFVLSQGEVYVLEVNPRSSRTVPFLSKITGIPMANLA TKIILGQKLAAFGYTEGLQPEQQGVFVKAPVFSFAKLRRVDITLGPEMKSTGEVMGKD STLEKALYKALIASGIQIPNYGSVLLTVADKDKEEGLAIAKRFHAIGYNILATEGTAG YLKEASIPAKVVGKIGQDGPNLLDVIRNGEAQFVINTLTKGKQPARDGFRIRRESVEN GVACLTSLDTAEAILRVLESMTFRADQMPAVNTNQEAAVTI*" /label="pyrAB CDS" gene 1497557..1500772 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /label="pyrAB gene" CDS 1500769..1501539 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /EC_number="1.3.98.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:169225, 10545205, 11188687, 15299876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 169225, 10545205, 11188687, 15299876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (electron transfer subunit)" /protein_id="NP_389436.1" /db_xref="EnsemblGenomes-Gn:BSU15530" /db_xref="EnsemblGenomes-Tr:CAB13427" /db_xref="GOA:P25983" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR012165" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR019480" /db_xref="InterPro:IPR023455" /db_xref="InterPro:IPR037117" /db_xref="SubtiList:BG10717" /db_xref="UniProtKB/Swiss-Prot:P25983" /translation="MKKAYLTVCSNQQIADRVFQMVLKGELVQGFTTPGQFLHLKVSE AVTPLLRRPISIADVNFEKNEVTIIYRVDGEGTRLLSLKQQGELVDVLGPLGNGFPVN EVQPGKTALLVGGGVGVPPLQELSKRLIEKGVNVIHVLGFQSAKDVFYEEECRQYGDT YVATADGSYGETGFVTDVIKRKKLEFDILLSCGPTPMLKALKQEYAHKEVYLSMEERM GCGIGACFACVCHTNESETSYVKVCLDGPVFKAQEVAL*" /label="pyrK CDS" gene 1500769..1501539 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /label="pyrK gene" CDS 1501539..1502474 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /EC_number="1.3.1.15" /experiment="publication(s) with functional evidences, PMID:4380263, 10545205" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4380263, 10545205; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (catalytic subunit)" /protein_id="NP_389437.1" /db_xref="EnsemblGenomes-Gn:BSU15540" /db_xref="EnsemblGenomes-Tr:CAB13428" /db_xref="GOA:P25996" /db_xref="InterPro:IPR001295" /db_xref="InterPro:IPR005720" /db_xref="InterPro:IPR012135" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024920" /db_xref="InterPro:IPR033888" /db_xref="SubtiList:BG10718" /db_xref="UniProtKB/Swiss-Prot:P25996" /translation="MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKA TTKEPRFGNPTPRVAETGAGMLNAIGLQNPGLDSVLHHELPWLEQFDTPIIANVAGSQ VDDYVEVAEHISKAPNVHALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDVPV YVKLSPNVANITEIALAIEEAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAV KPVAIRMVYEVSQMVNIPIIGMGGVQTAEDALEFLLAGASAVAVGTANFVNPFACPEI IEQLPSVLLQYGYQSIEECIGRSWNHEKQPAHHRA*" /label="pyrD CDS" gene 1501539..1502474 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /label="pyrD gene" CDS 1502443..1503162 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /EC_number="4.1.1.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10681442, 11390694, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10681442, 11390694, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotidine 5'-phosphate decarboxylase" /protein_id="NP_389438.1" /db_xref="EnsemblGenomes-Gn:BSU15550" /db_xref="EnsemblGenomes-Tr:CAB13429" /db_xref="GOA:P25971" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014732" /db_xref="InterPro:IPR018089" /db_xref="PDB:1DBT" /db_xref="SubtiList:BG10719" /db_xref="UniProtKB/Swiss-Prot:P25971" /translation="MKNNLPIIALDFASAEETLAFLAPFQQEPLFVKVGMELFYQEGP SIVKQLKERNCELFLDLKLHDIPTTVNKAMKRLASLGVDLVNVHAAGGKKMMQAALEG LEEGTPAGKKRPSLIAVTQLTSTSEQIMKDELLIEKSLIDTVVHYSKQAEESGLDGVV CSVHEAKAIYQAVSPSFLTVTPGIRMSEDAANDQVRVATPAIAREKGSSAIVVGRSIT KAEDPVKAYKAVRLEWEGIKS*" /label="pyrF CDS" gene 1502443..1503162 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /label="pyrF gene" CDS 1503141..1503791 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /EC_number="2.4.2.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9305779, 22447609, 23405251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotate phosphoribosyltransferase" /protein_id="NP_389439.1" /db_xref="EnsemblGenomes-Gn:BSU15560" /db_xref="EnsemblGenomes-Tr:CAB13430" /db_xref="GOA:P25972" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR004467" /db_xref="InterPro:IPR023031" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10720" /db_xref="UniProtKB/Swiss-Prot:P25972" /translation="MGGNQILKQIIAKHLLDIQAVFLRPNEPFTWASGILSPIYCDNR LTLSFPEVRNDVASGISKLVKEHFPEAEMIAGTATAGIPHAALAADHLNLPMCYVRSK PKAHGKGNQIEGAVQEGQKTVVIEDLISTGGSVLEACAALQAAGCEVLGVVSIFTYGL PKAEEAFAKAELPYYSLTDYDTLTEVALENGNIHSDDLKKLQTWKRNPESKDWFKK*" /label="pyrE CDS" gene 1503141..1503791 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /label="pyrE gene" downshifts 1503793 /Source="Nicolas_upshifts" /id="D874" /incds=0 /nref=17 /ntot=184 /MaxReadThrough="3.91018" /MaxDrop="5.49939" /score="33.4515727" /energy="-9" /TU="U1287,U1288" /idTUdmin="U1287" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" S_feature 1503838..1503910 /Source="Nicolas_S_feature" /locus_tag="new_1630017_1630089" /HighExp="Cold, Gly, MG 5, S0, LPh, M/G, GM 60, MG t5, Mal, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S568" promotor_-35 1503890..1503897 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1503911..1503930 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1503912 /Source="Nicolas_upshifts" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1503936..1504041 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /label="mswE RNA" gene 1503936..1504041 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /label="mswE gene" S_feature 1504042..1504202 /Source="Nicolas_S_feature" /locus_tag="new_1630221_1630381" /HighExp="MG 10, B60, MG 5, MG t5, M9-exp, MG 25, MG 60, MG 15, GM 90, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S569" CDS 1504203..1504904 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10094622, 11004190, 12072441, 16267287, 18456801" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 11004190, 12072441, 16267287, 18456801; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(phospho)adenosine phosphosulfate reductase" /protein_id="NP_389440.1" /db_xref="EnsemblGenomes-Gn:BSU15570" /db_xref="EnsemblGenomes-Tr:CAB13431" /db_xref="GOA:P94498" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11930" /db_xref="UniProtKB/Swiss-Prot:P94498" /translation="MLTYDNWEEPTITFPEDDPYKGALSVLKWAYGHYGDQLVYACSF GIEGIVLIDLIYKVKKDAEIVFLDTGLHFKETYETIERVKERYPGLNIILKKPDLTLE EQAEEHGDKLWEREPNQCCYLRKVVPLREALSGHPAWLSGLRRDQGPSRANTNFLNKD EKFKSVKVCPLIHWTWKDIWRYTSRNELDYNPLHDQGYPSIGCAPCTSPAFTAEDLRS GRWNGMAKTECGLHE*" /label="cysH CDS" gene 1504203..1504904 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /label="cysH gene" CDS 1504916..1505980 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 10784039, 11004190, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 10784039, 11004190, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfate permease" /protein_id="NP_389441.1" /db_xref="EnsemblGenomes-Gn:BSU15580" /db_xref="EnsemblGenomes-Tr:CAB13432" /db_xref="GOA:O34734" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13377" /db_xref="UniProtKB/Swiss-Prot:O34734" /translation="MELAAILFSLFFAMNIGASGAAASMGVAYGSGAIKKKTYALILC AVGVFAGAVIGGGEVVKTISSGIIPEQTITLTIVCIIIGAAALSLFTANLLGIPLSTS EVTVGAVVGVGVAYKVLFVNNLLIIVSFWVFVPLFAFGFTYFVSKLFRYFKIEVKSSK KQKILGIVLLVAGFFEAFSAGMNNVANAVGPLVAAGVLDVGKGTLYGGAFVALGALLL GRRVLETNGKKITRFSKGEGILLSGTGAGLVIISSVFGMPVPLAQVTSSSIIGIGMAK NGPNVFHKQVVQTMLKVWIVSPFLSLSISYLLVSLFLKADYYSIFIMVSVLLAAGGAI SLTKAIRKERRSVHEQGGGI*" /label="cysP CDS" gene 1504916..1505980 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /label="cysP gene" CDS 1506029..1507177 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /EC_number="2.7.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 11004190, 11274114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfate adenylyltransferase" /protein_id="NP_389442.1" /db_xref="EnsemblGenomes-Gn:BSU15590" /db_xref="EnsemblGenomes-Tr:CAB13433" /db_xref="GOA:O34764" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13378" /db_xref="UniProtKB/Swiss-Prot:O34764" /translation="MSLAPHGGTLVNRVDESYDVSGIQKEIELDLISFADLELIGIGA YSPIEGFFNEKDYVSVVENMRLSSGVVWSLPITLPVDAQKAAELSLGETVKLTYEGET YGVIQIEDLYVPDKQKEAVNVYKTDEQEHPGVKKLFSRGNTYVGGPITLIKKASKQFP EFTFEPSETRRQFAEKGWETIVGFQTRNPVHRAHEYIQKTALETVDGLFLNPLVGETK SDDIPADVRMESYQVLLDHYYPKDRVFLGVFLAAMRYAGPREAIFHALVRKNYGCTHF IVGRDHAGVGDYYGTYEAQELFDTFKPEELGITPLKFEHSFFCKKCGNMGTAKTCPHG REHHVILSGTKVRGMLRDGVLPPAEFSRKEVVEVLIKGMKKKEEVGVS*" /label="sat CDS" gene 1506029..1507177 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /label="sat gene" upshifts complement(1506118) /Source="Nicolas_upshifts" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1506130..1506134) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1506152..1506153) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1507190..1507783 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /EC_number="2.7.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1332767, 10094622, 11004190, 19067028, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylylsulfate kinase" /protein_id="NP_389443.1" /db_xref="EnsemblGenomes-Gn:BSU15600" /db_xref="EnsemblGenomes-Tr:CAB13434" /db_xref="GOA:O34577" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13379" /db_xref="UniProtKB/Swiss-Prot:O34577" /translation="MTNRDIVWHEASITKEEYQQKNKHKSSILWLTGLSGSGKSTIAN AAARELFEQGYQVIVLDGDNIRHGLNRDLGFSDEDRKENIRRIGEVAKLFVQQGTIVI TAFISPFREDRQQVRELVEAGEFNEVYIKCDLDICEQRDPKGLYKKARNGEIPFFTGI DSPYEEPEAPELVLDSGQHDREACKNQLIEFVKQKLS*" /label="cysC CDS" gene 1507190..1507783 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /label="cysC gene" S_feature 1507784..1507881 /Source="Nicolas_S_feature" /locus_tag="new_1633963_1634060" /HighExp="MG 10, B36, MG 5, MG t5, B60, MG 15, MG 90, MG-0.2, MG 60, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S570" CDS 1507882..1508655 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /EC_number="2.1.1.107" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1906874, 11004190, 10094622, 19154787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III and precorrin-1 C-methyltransferase" /protein_id="NP_389444.1" /db_xref="EnsemblGenomes-Gn:BSU15610" /db_xref="EnsemblGenomes-Tr:CAB13435" /db_xref="GOA:O34744" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG13380" /db_xref="UniProtKB/Swiss-Prot:O34744" /translation="MGKVYIVGAGPGDPDLLTIKALKAIEKADVILYDRLVNKEILQY AKEQADLIYCGKLPDFHTMKQETINRFLVKYAQKGKMVVRLKGGDPFVFGRGGEEAEC LSENGIPFEIIPGITSGIAAAAYAGIPVTHRDAGSNVAFVTGHYKKEEDFEEKWKALA TGIDTLVIYMGIKNVQQIERKLLENGRDGSTPAAFIHWGTTDKQKSVFCTVDTLSETV IKENITNPSLIVIGNVVNYHYKLEWFESELKKQDLSEAL*" /label="sumT CDS" gene 1507882..1508655 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /label="sumT gene" promotor_-35 1508560..1508567 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1508582..1508601 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1508583 /Source="Nicolas_upshifts" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" CDS 1508658..1509443 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /EC_number="4.99.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirohydrochlorin ferrochelatase" /protein_id="NP_389445.1" /db_xref="EnsemblGenomes-Gn:BSU15620" /db_xref="EnsemblGenomes-Tr:CAB13436" /db_xref="GOA:O34632" /db_xref="InterPro:IPR002762" /db_xref="SubtiList:BG13381" /db_xref="UniProtKB/Swiss-Prot:O34632" /translation="MKQAILYVGHGSRVKKAQQEAAAFLEGCKAHISVPVQEISFLEL QEPTIETGFEACVKQGATHIAVVPLLLLTAAHAKHDIPEEIVRVASRYPSVRISYGKP IGIDEEVVKAVYHRMKDIGVPYENARVVLIGRGSSDPDVKRDVTGIANLLQEMVPVKE VIPCFLTACGPNYKEVFSELEKDDGITTFIVPYLLFTGMLMNEIEREVQKLKAHNPNV YLSSYIGFHPHVKNAFLNRVRETAANSEGQFDFDGGSYASAAH*" /label="sirB CDS" gene 1508658..1509443 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /label="sirB gene" CDS 1509424..1509912 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /EC_number="1.3.1.76" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752, 18588505; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="precorrin-2 dehydrogenase" /protein_id="NP_389446.1" /db_xref="EnsemblGenomes-Gn:BSU15630" /db_xref="EnsemblGenomes-Tr:CAB13437" /db_xref="GOA:O34813" /db_xref="InterPro:IPR006367" /db_xref="InterPro:IPR028161" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13382" /db_xref="UniProtKB/Swiss-Prot:O34813" /translation="MLPLHISLEKKKVVIAGGGSIALRRLKTVISEGADITLVSPDVE PEIKQMAEERRIKWEKRTIEKEDYLNAFFIIAATDNAAVNKEIAQSASPFQLVNCVSD AELGNVYMPKIVKRGHVTVSVSTSGASPKHTKELAENVDKLIDGDFVAEVNRLYQMRR KK*" /label="sirC CDS" gene 1509424..1509912 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /label="sirC gene" downshifts 1509892 /Source="Nicolas_upshifts" /id="D875" /incds=0 /nref=256 /ntot=267 /MaxReadThrough="2.85828" /MaxDrop="8.90139" /score="26.5923498" /energy="-16.6" /TU="U1289" /idTUdmin="U1291" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1509939) /Source="Nicolas_upshifts" /id="D876" /incds=0 /nref=149 /ntot=238 /MaxReadThrough="1.71588" /MaxDrop="5.36964" /score="15.559144" /energy="-16.6" /TU="NA" /idTUdmin="U1292" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1509952..1511670) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11238985, 17586671, 24646681, 28294433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA modification protein" /protein_id="NP_389447.1" /db_xref="EnsemblGenomes-Gn:BSU15640" /db_xref="EnsemblGenomes-Tr:CAB13438" /db_xref="InterPro:IPR008532" /db_xref="SubtiList:BG13383" /db_xref="UniProtKB/Swiss-Prot:O34693" /translation="MHMSFDGMFTYGMTHELNEKIMGGRITKIHQPYKHDVIFHIRAK GKNQKLLLSAHPSYSRVHITAQAYENPSEPPMFCMLLRKHIEGGFIEKIEQAGLDRIM IFHIKSRNEIGDETVRKLYVEIMGRHSNIILTDAAENVIIDGLKHLSPSMNSYRTVLP GQDYKLPPAQDKISPLEASEDDILRHLSFQEGRLDKQIVDHFSGVSPLFAKEAVHRAG LANKVTLPKALLALFAEVKEHRFIPNITTVNGKEYFYLLELTHLKGEARRFDSLSELL DRFYFGKAERDRVKQQAQDLERFVVNERKKNANKIKKLEKTLEYSENAKEFQLYGELL TANLYMLKKGDKQAEVINYYDEESPTITIPLNPNKTPSENAQAYFTKYQKAKNSVAVV EEQIRLAQEEIEYFDQLIQQLSSASPRDISEIREELVEGKYLRPKQQKGQKKQKPHNP VLETYESTSGLTILVGKNNRQNEYLTTRVAARDDIWLHTKDIPGSHVVIRSSEPDEQT IMEAATIAAYFSKAKDSSSVPVDYTKIRHVKKPNGAKPGFVTYDSQHTVFVTPDADTV IKLKKS*" /label="fbnA CDS" gene complement(1509952..1511670) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /label="fbnA gene" promotor_-10 complement(1511692..1511711) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1511706..1511711 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-35" upshifts complement(1511706) /Source="Nicolas_upshifts" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1511724..1511729) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1511727..1511745 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-10" upshifts 1511731 /Source="Nicolas_upshifts" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="upshifts" CDS 1511786..1514458 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12161109, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12161109, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="P-type calcium transport ATPase (sporulation)" /protein_id="NP_389448.1" /db_xref="EnsemblGenomes-Gn:BSU15650" /db_xref="EnsemblGenomes-Tr:CAB13439" /db_xref="GOA:O34431" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR004014" /db_xref="InterPro:IPR005782" /db_xref="InterPro:IPR006068" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13384" /db_xref="UniProtKB/Swiss-Prot:O34431" /translation="MKFHEMGQTDLLEATNTSMKQGLTEKEVKKRLDKHGPNELQEGK KTSALLLFFAQFKDFMVLVLLAATLISGFLGEYVDAVAIIAIVFVNGILGFFQERRAE QSLQALKELSTPHVMALREGSWTKIPSKELVPGDIVKFTSGDRIGADVRIVEARSLEI EESALTGESIPVVKHADKLKKPDVSLGDITNMAFMGTIVTRGSGVGVVVGTGMNTAMG KIADMLESAGTLSTPLQRRLEQLGKILIVVALLLTVLVVAVGVIQGHDLYSMFLAGVS LAVAAIPEGLPAIVTVALSLGVQRMIKQKSIVRKLPAVETLGCASIICSDKTGTMTQN KMTVTHVWSGGKTWRVAGAGYEPKGSFTLNEKEISVNEHKPLQQMLLFGALCNNSNIE KRDGEYVLDGDPTEGALLTAARKGGFSKEFVESNYRVIEEFPFDSARKMMTVIVENQD RKRYIITKGAPDVLMQRSSRIYYDGSAALFSNERKAETEAVLRHLASQALRTIAVAYR PIKAGETPSMEQAEKDLTMLGLSGIIDPPRPEVRQAIKECREAGIKTVMITGDHVETA KAIAKDLRLLPKSGKIMDGKMLNELSQEELSHVVEDVYVFARVSPEHKLKIVKAYQEN GHIVAMTGDGVNDAPAIKQADIGVSMGITGTDVAKEASSLVLVDDNFATIKSAIKEGR NIYENIRKFIRYLLASNVGEILVMLFAMLLALPLPLVPIQILWVNLVTDGLPAMALGM DQPEGDVMKRKPRHPKEGVFARKLGWKVVSRGFLIGVATILAFIIVYHRNPENLAYAQ TIAFATLVLAQLIHVFDCRSETSVFSRNPFQNLYLIGAVLSSILLMLVVIYYPPLQPI FHTVAITPGDWMLVIGMSAIPTFLLAGSLLTRKK*" /label="tcaB CDS" gene 1511786..1514458 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /label="tcaB gene" promotor_-10 complement(1513191..1513210) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1513202) /Source="Nicolas_upshifts" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1513225..1513232) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1514464..1514483 /Source="Nicolas_upshift_promotors" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1514467..1514540 /Source="Nicolas_S_feature" /locus_tag="new_1640646_1640719" /HighExp="LPhT, LBGstat, T3.0H, H2O2, T3.30H, Salt, B60, Lbexp, UNK1, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.994, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S571" upshifts 1514467 /Source="Nicolas_upshifts" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1514541..1515416 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389449.1" /db_xref="EnsemblGenomes-Gn:BSU15660" /db_xref="EnsemblGenomes-Tr:CAB13440" /db_xref="InterPro:IPR005229" /db_xref="InterPro:IPR013527" /db_xref="InterPro:IPR013551" /db_xref="SubtiList:BG13385" /db_xref="UniProtKB/Swiss-Prot:O34441" /translation="MIRSMTGFGSASKTQDDLSVSVELKSVNYRFKEVNARLPRPLLY FEDKLKQTILQHIQRGRIELFVSVDSDMLVEKRLEIDWPLLDEFVAAARDMKKRYQLS AEPDVMDFFKLDHVVQVHEEQTQNDKLEALIIDAAEEAVKGLCEMREKEGLLLAKDCL MHIDQLEELVRETELLAADVVSRYRERLYARIKEWTEDVLDESRLVTECAIFADRSDI TEEITRLKSHFAQFRDILASGGAVGRKLDFLVQELNREANTIGSKANDHQITKLVVEM KSSIEKIKEQVQNIE*" /label="yloC CDS" gene 1514541..1515416 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /label="yloC gene" CDS 1515493..1515762 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116, 23396918, 23646920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116, 23396918, 23646920; Product type r: regulator" /codon_start=1 /transl_table=11 /product="essential sporulation DNA binding protein; regulator of biofilm formation" /protein_id="NP_570902.1" /db_xref="EnsemblGenomes-Gn:BSU15670" /db_xref="EnsemblGenomes-Tr:CAE01452" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG14185" /db_xref="UniProtKB/Swiss-Prot:Q7WY72" /translation="MTIKLINIGFGNIISANRMISIVSPESAPIKRMIQDARDRGMLI DATYGRRTRAVVVMDSDHIILSAVQPETVAHRLSVKEEIMDEGQG*" /label="remA CDS" gene 1515493..1515762 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /label="remA gene" misc_feature complement(1515573..1515577) /Source="Nicolas_upshift_promotors" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1515578) /Source="Nicolas_upshifts" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1515770..1516384 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /EC_number="2.7.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17012781, 24722991" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17012781, 24722991; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanylate kinase" /protein_id="NP_389450.2" /db_xref="EnsemblGenomes-Gn:BSU15680" /db_xref="EnsemblGenomes-Tr:CAB13441" /db_xref="GOA:O34328" /db_xref="InterPro:IPR008144" /db_xref="InterPro:IPR008145" /db_xref="InterPro:IPR017665" /db_xref="InterPro:IPR020590" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13386" /db_xref="UniProtKB/Swiss-Prot:O34328" /translation="MKERGLLIVLSGPSGVGKGTVRQAIFSQEDTKFEYSISVTTRSP REGEVNGVDYFFKTRDEFEQMIADNKLLEWAEYVGNYYGTPVDYVEQTLQDGKDVFLE IEVQGALQVRNAFPEGLFIFLAPPSLSELKNRIVTRGTETDALIENRMKAAKAEIEMM DAYDYVVENDNVETACDKIKAIVLAEHLKRERVAPRYKKMLEVE*" /label="gmk CDS" gene 1515770..1516384 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /label="gmk gene" CDS 1516388..1516591 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12089032, 16159791, 17233676, 24476911, 25878038; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega subunit of RNA polymerase" /protein_id="NP_389451.1" /db_xref="EnsemblGenomes-Gn:BSU15690" /db_xref="EnsemblGenomes-Tr:CAB13442" /db_xref="GOA:O35011" /db_xref="InterPro:IPR003716" /db_xref="InterPro:IPR006110" /db_xref="InterPro:IPR012293" /db_xref="InterPro:IPR036161" /db_xref="SubtiList:BG13387" /db_xref="UniProtKB/Swiss-Prot:O35011" /translation="MLDPSIDSLMNKLDSKYTLVTVSARRAREMQIKKDQMIEHTISH KYVGKALEEIDAGLLSFEKEDRE*" /label="rpoZ CDS" gene 1516388..1516591 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /label="rpoZ gene" downshifts 1516580 /Source="Nicolas_upshifts" /id="D877" /incds=0 /nref=118 /ntot=257 /MaxReadThrough="5.65143" /MaxDrop="4.7291" /score="-8.13961715" /energy="-7.7" /TU="U1293,U1295" /idTUdmin="U1293" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS 1516672..1517892 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /EC_number="4.1.1.36" /EC_number="6.3.2.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11278255, 11358972, 12140293, 14686929, 15530362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coenzyme A biosynthesis bifunctional protein CoaBC; phosphopantothenoylcysteine synthetase/decarboxylase" /protein_id="NP_389452.1" /db_xref="EnsemblGenomes-Gn:BSU15700" /db_xref="EnsemblGenomes-Tr:CAB13443" /db_xref="GOA:O35033" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR005252" /db_xref="InterPro:IPR007085" /db_xref="InterPro:IPR035929" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG13388" /db_xref="UniProtKB/Swiss-Prot:O35033" /translation="MLNNRNVLLCVSGGIAVYKACALTSKLVQAGANVKVIMTESACR FVSPLTFQALSRHEVYTDTFKEQNPSVISHIDAADWADLIIVAPATANVIGKLANGIA DDMLTTTLLAATAPVWIAPAMNVHMYDHPAVKRNISVLYQDGYCFIEPSEGYLACGYV GKGRLEEPENIVKLAEKHFAEETSAPLEGKHVVITAGPTREAIDPVRFFTNKSTGKMG YALAEAAVQLGARVILISGPVSLDQPKGLAEFIPVQSAADMREAVLSVYDASDIVIKT AAVADFTPKTVFDHKMKKQDGGMTLELKRTVDILKELGEKKKEQILVGFAAETQDIEH YARKKLAAKNLDLIVANDVKANGAGFGADTNIVTIFFKDGHKRELPIMSKLDVSFEIL QEIAALSKQTGERS*" /label="coaBC CDS" gene 1516672..1517892 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /label="coaBC gene" S_feature complement(1517731..1518306) /Source="Nicolas_S_feature" /locus_tag="new_1643910_1644485_c" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, B60, LPhT, HiTm, Heat" /AntisenseName="priA" /AntisenseCor="-5.1213364637925501E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S572" CDS 1517889..1520306 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10572298, 11917020, 12682299, 21170359, 22720735, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572298, 11917020, 12682299, 21170359, 22720735, 28527403; Product type f : factor" /codon_start=1 /transl_table=11 /product="primosomal replication factor Y (primosomal protein N')" /protein_id="NP_389453.1" /db_xref="EnsemblGenomes-Gn:BSU15710" /db_xref="EnsemblGenomes-Tr:CAB13444" /db_xref="GOA:P94461" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005259" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11963" /db_xref="UniProtKB/Swiss-Prot:P94461" /translation="MNFAEVIVDVSTKNIDRPFDYKIPDHLKGMIKTGMRVIVPFGPR KIQGFVTAVKEASDLSGKSVKEVEDLLDLTPVLTEELMILSSWLSDKTLSFKITALQA MLPAALKAKYEKELKIAHGADLPPQVERLFSETKTLLYSDIPDHETLKLIQRHVQKGD IDVTYKVAQKTNKKMVRHIQANASKEELAKQAEGLSRQAAKQQAILHFLISEPEGVKI PAAELCKKTDTSSATIKTLIQKGLLKESYEEVYRDPYQDKMFKKTEPLPLTDEQRAAF EPIRETLDSDEHKVFLLHGVTGSGKTEIYLQSIEKVLAKGKEAIVLVPEISLTPQMVN RFKGRFGSQVAVMHSGLSTGEKYDEWRKIHRKEVRLVVGARSAIFAPFENLGMIIIDE EHESSYKQEEMPRYHAKEVAIKRAEHHSCPVVLGSATPTLESYARAQKGVYELLSLKH RVNHRVMPEVSLVDMREELRNGNRSMFSVELMEKLEETIAKGEQAVLFLNKRGYSSFV MCRDCGYVPQCPHCDISMTYHRYGQRLKCHYCGHEEPVPHTCPECASEHIRFFGTGTQ RVEEELTKVLPSARVIRMDVDTTSRKGAHEKLLSAFGEGKADILLGTQMIAKGLDFPN VTLVGVLSADTTLHIPDFRSAEKTFQLLTQVSGRAGRHEKPGHVIIQTYTPSHYSIQL TKTHDYETFYQHEMAHRREQSYPPYYYLALVTVSHEEVAKAAVTAEKIAHFLKANCGA DTKILGPSASPIARIKDRYRYQCVIKYKQETQLSALLKKILEHYKREIEQKHVMISID MNPYMMM*" /label="priA CDS" gene 1517889..1520306 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /label="priA gene" promotor_-10 complement(1518302..1518320) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1518306) /Source="Nicolas_upshifts" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1518334..1518340) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1520157..1520161 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1520177..1520196 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1520188 /Source="Nicolas_upshifts" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1520333..1520815 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /EC_number="3.5.1.88" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11429456, 16014871, 16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16014871, 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide deformylase" /protein_id="NP_389454.1" /db_xref="EnsemblGenomes-Gn:BSU15720" /db_xref="EnsemblGenomes-Tr:CAB13445" /db_xref="GOA:P94462" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11933" /db_xref="UniProtKB/Swiss-Prot:P94462" /translation="MAVKKVVTHPAEVLETPAETVTVFDKKLKKLLDDMYDTMLEMDG VGLAAPQIGILKRAAVVEIGDDRGRIDLVNPEILEKSGEQTGIEGCLSFPNVYGDVTR ADYVKVRAFNRQGKPFILEARGFLARAVQHEMDHLDGVLFTSKISKYYTEDELADMEG *" /label="defA CDS" gene 1520333..1520815 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /label="defA gene" CDS 1520820..1521773 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /EC_number="2.1.2.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA formyltransferase" /protein_id="NP_389455.1" /db_xref="EnsemblGenomes-Gn:BSU15730" /db_xref="EnsemblGenomes-Tr:CAB13446" /db_xref="GOA:P94463" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR005793" /db_xref="InterPro:IPR005794" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036477" /db_xref="InterPro:IPR037022" /db_xref="SubtiList:BG11937" /db_xref="UniProtKB/Swiss-Prot:P94463" /translation="MTRIVFMGTPDFSVPVLRTLIEDGYEVVGVVTQPDRPKGRKKVL TPPPVKEEALRHGIPVLQPEKVRLTEEIEKVLALKPDLIVTAAFGQILPKELLDSPKY GCINVHASLLPELRGGAPIHYSILQGKKKTGITIMYMVEKLDAGDMISKVEVDIEETD NVGTLHDKLSVAGAKLLSETVPNVIAGSISPEKQDEEKATYAPNIKREQELLDWSRTG EELYNQIRGLNPWPVAYTTLNGQNLKIWASKKIAAPTTAEPGTVVAVEKEGIIVATGN ETALLLTELQPAGKKRMKGEDFVRGAHVEAGDVLGVNNEKN*" /label="fmt CDS" gene 1520820..1521773 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /label="fmt gene" CDS 1521760..1523103 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /EC_number="2.1.1.176" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14656444, 23729652, 27698115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA-binding Sun protein; 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent" /protein_id="NP_389456.1" /db_xref="EnsemblGenomes-Gn:BSU15740" /db_xref="EnsemblGenomes-Tr:CAB13447" /db_xref="GOA:P94464" /db_xref="InterPro:IPR001678" /db_xref="InterPro:IPR004573" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR018314" /db_xref="InterPro:IPR023267" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG12253" /db_xref="UniProtKB/Swiss-Prot:P94464" /translation="MKKTSVRDIALEALIKLEQNQAYSNLLLKSVIKSNELSDQNRGL LTELVYGTLQNKIALDYMLKPFINKPQKVKPWVIQLLRLSLYQMEYLEKIPDRAAIHE AVEIAKIRGHKGIASFVNGVLRSIQREGVPSFDAIEDPVRRLATETSHPEWLVKEWAD AYGFEAAEKICRIHLIPPKQTLRVNQMKADRAELLDQMAAEGIEVEKGDLAEDAVKLL KGTIAGTHFFQNGEVSIQDESSMLVARALDPKSDETVLDACAAPGGKSAHIAELMKNK GSVTSLDLHKHKVKLIKEAADRLGLTIIHAETMDARKAGETFENEQFDRILVDAPCSG FGVIRRKPDMKYTKKPDDSARLAEIQLSILREIAPLVKKGGTLVYSTCTMDRTENDEV IHAFIQEHPDFEPDLSLEKRLPEKVRPFVRDGRLQILPHYFGTDGFFICSMRKKG*" /label="rsmB CDS" gene 1521760..1523103 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /label="rsmB gene" CDS 1523107..1524198 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /EC_number="2.1.1.192" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8973346, 18307109, 20184321, 21368151, 22891362, 27081063, 27902775; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2A2503 methyltransferase and tRNA A37 C2 methyltransferase" /protein_id="NP_389457.1" /db_xref="EnsemblGenomes-Gn:BSU15750" /db_xref="EnsemblGenomes-Tr:CAB13448" /db_xref="GOA:O34617" /db_xref="InterPro:IPR004383" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR027492" /db_xref="SubtiList:BG13389" /db_xref="UniProtKB/Swiss-Prot:O34617" /translation="MAELNKTKVRKELRTERPSIYSFELDEIKQWLTDNGEKPFRAAQ IFEWLYEKRVSSFEDMTNLSKDLREKLNTRFVLTTLKTAVKQTSQDGTMKFLFELHDG YTIETVLMRHEYGNSVCVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVAQVVKVQKAL DETDERVSSVVIMGIGEPFDNFNEMLAFLKIINHDKGLNIGARHITVSTSGIIPKIYE FADQQMQINFAISLHAPNTEIRSRLMPINRAYKLPDLMEAVKYYINKTGRRISFEYGL FGGVNDQVEHAEELADLLEGVKCHVNLIPVNYVPERDYVRTPRDQIFAFEKTLKSRGV NVTIRREQGHDIDAACGQLRAKERQDETR*" /label="rlmN CDS" gene 1523107..1524198 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /label="rlmN gene" CDS 1524205..1524969 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /EC_number="3.1.3.16" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 17693724, 22720735, 24390483, 25012659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 17693724, 22720735, 24390483, 25012659; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="multitarget phosphorylated protein phosphatase" /protein_id="NP_389458.1" /db_xref="EnsemblGenomes-Gn:BSU15760" /db_xref="EnsemblGenomes-Tr:CAB13449" /db_xref="GOA:O34779" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR015655" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG13390" /db_xref="UniProtKB/Swiss-Prot:O34779" /translation="MLTALKTDTGKIRQHNEDDAGIFKGKDEFILAVVADGMGGHLAG DVASKMAVKAMGEKWNEAETIPTAPSECEKWLIEQILSVNSKIYDHAQAHEECQGMGT TIVCALFTGKTVSVAHIGDSRCYLLQDDDFVQVTEDHSLVNELVRTGEISREDAEHHP RKNVLTKALGTDQLVSIDTRSFDIEPGDKLLLCSDGLTNKVEGTELKDILQSDSAPQE KVNLLVDKANQNGGEDNITAVLLELALQVEEGEDQC*" /label="prpC CDS" gene 1524205..1524969 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /label="prpC gene" downshifts 1524258 /Source="Nicolas_upshifts" /id="D878" /incds=0 /nref=5 /ntot=126 /MaxReadThrough="6.12318" /MaxDrop="3.8594" /score="-7.80200272" /energy="-10" /TU="U1295,U1298" /idTUdmin="U1300" /TUdmin="-4708" /isTUend="FALSE" /label="downshifts" CDS 1524963..1526909 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /EC_number="2.7.11.1" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 18984160, 24390483, 25845974, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 18984160, 24390483, 25845974, 26102633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine/threonine kinase" /protein_id="NP_389459.1" /db_xref="EnsemblGenomes-Gn:BSU15770" /db_xref="EnsemblGenomes-Tr:CAB13450" /db_xref="GOA:O34507" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR008271" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13391" /db_xref="UniProtKB/Swiss-Prot:O34507" /translation="MLIGKRISGRYQILRVIGGGGMANVYLAEDIILDREVAIKILRF DYANDNEFIRRFRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITA NGPLHPKEALNIMEQIVSAIAHAHQNQIVHRDIKPHNILIDHMGNIKVTDFGIATALS STTITHTNSVLGSVHYLSPEQARGGLATKKSDIYALGIVLFELLTGRIPFDGESAVSI ALKHLQAETPSAKRWNPSVPQSVENIILKATAKDPFHRYETAEDMEADIKTAFDADRL NEKRFTIQEDEEMTKAIPIIKDEELAKAAGEKEAEVTTAQENKTKKNGKRKKWPWVLL TICLVFITAGILAVTVFPSLFMPKDVKIPDVSGMEYEKAAGLLEKEGLQVDSEVLEIS DEKIEEGLMVKTDPKADTTVKEGATVTLYKSTGKAKTEIGDVTGQTVDQAKKALKDQG FNHVTVNEVNDEKNAGTVIDQNPSAGTELVPSEDQVKLTVSIGPEDITLRDLKTYSKE AASGYLEDNGLKLVEKEAYSDDVPEGQVVKQKPAAGTAVKPGNEVEVTFSLGPEKKPA KTVKEKVKIPYEPENEGDELQVQIAVDDADHSISDTYEEFKIKEPTERTIELKIEPGQ KGYYQVMVNNKVVSYKTIEYPKDE*" /label="prkC CDS" gene 1524963..1526909 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /label="prkC gene" promotor_-35 1526818..1526824 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1526838..1526856 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1526854 /Source="Nicolas_upshifts" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1526924..1527820 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome biogenesis" /protein_id="NP_389460.1" /db_xref="EnsemblGenomes-Gn:BSU15780" /db_xref="EnsemblGenomes-Tr:CAB13451" /db_xref="GOA:O34530" /db_xref="InterPro:IPR004881" /db_xref="InterPro:IPR010914" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="InterPro:IPR031944" /db_xref="PDB:1T9H" /db_xref="SubtiList:BG13392" /db_xref="UniProtKB/Swiss-Prot:O34530" /translation="MPEGKIIKALSGFYYVLDESEDSDKVIQCRGRGIFRKNKITPLV GDYVVYQAENDKEGYLMEIKERTNELIRPPICNVDQAVLVFSAVQPSFSTALLDRFLV LVEANDIQPIICITKMDLIEDQDTEDTIQAYAEDYRNIGYDVYLTSSKDQDSLADIIP HFQDKTTVFAGQSGVGKSSLLNAISPELGLRTNEISEHLGRGKHTTRHVELIHTSGGL VADTPGFSSLEFTDIEEEELGYTFPDIREKSSSCKFRGCLHLKEPKCAVKQAVEDGEL KQYRYDHYVEFMTEIKDRKPRY*" /label="rsgA CDS" gene 1526924..1527820 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /label="rsgA gene" CDS 1527825..1528478 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /EC_number="5.1.3.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 973353, 15755726, 16489742, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribulose-5-phosphate 3-epimerase" /protein_id="NP_389461.1" /db_xref="EnsemblGenomes-Gn:BSU15790" /db_xref="EnsemblGenomes-Tr:CAB13452" /db_xref="GOA:O34557" /db_xref="InterPro:IPR000056" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR026019" /db_xref="SubtiList:BG13393" /db_xref="UniProtKB/Swiss-Prot:O34557" /translation="MIKVAPSILSADFAALGNEIKDVEKGGADCIHIDVMDGHFVPNI TIGPLIVEAVRPVTDLPLDVHLMIEEPDRYIPAFAKAGADILSVHAEACPHLHRTIQL IKEQGVKAGVVLNPHTPVQVIEHVFDDLDLVLLMTVNPGFGGQKFIHSVLPKIKEVKR MADEKGKKDLLIEVDGGVNKETAPLVIEAGANLLVAGSAVYGQSDRKKAISEIRGSK* " /label="rpe CDS" gene 1527825..1528478 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /label="rpe gene" promotor_-35 1528476..1528485 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-35" promotor_-10 1528499..1528518 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-10" upshifts 1528504 /Source="Nicolas_upshifts" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="upshifts" CDS 1528551..1529195 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /EC_number="2.7.6.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14567704, 15150256, 16291685, 19490098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine pyrophosphokinase" /protein_id="NP_389462.1" /db_xref="EnsemblGenomes-Gn:BSU15800" /db_xref="EnsemblGenomes-Tr:CAB13453" /db_xref="GOA:O34664" /db_xref="InterPro:IPR006282" /db_xref="InterPro:IPR007371" /db_xref="InterPro:IPR007373" /db_xref="InterPro:IPR036371" /db_xref="InterPro:IPR036759" /db_xref="PDB:3LM8" /db_xref="SubtiList:BG13394" /db_xref="UniProtKB/Swiss-Prot:O34664" /translation="MKTINIVAGGPKNLIPDLTGYTDEHTLWIGVDKGTVTLLDAGII PVEAFGDFDSITEQERRRIEKAAPALHVYQAEKDQTDLDLALDWALEKQPDIIQIFGI TGGRADHFLGNIQLLYKGVKTNIKIRLIDKQNHIQMFPPGEYDIEKDENKRYISFIPF SEDIHELTLTGFKYPLNNCHITLGSTLCISNELIHSRGTFSFAKGILIMIRSTD*" /label="thiN CDS" gene 1528551..1529195 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /label="thiN gene" promotor_-35 1528956..1528962 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-35" upshifts 1528973 /Source="Nicolas_upshifts" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="upshifts" promotor_-10 1528977..1528995 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-10" promotor_-35 1529086..1529091 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1529107..1529125 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1529120 /Source="Nicolas_upshifts" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1529196..1529266 /Source="Nicolas_S_feature" /locus_tag="new_1655375_1655445" /HighExp="S4, S5, S7, S8, S6, S3, B36, G/S, B60, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigB, SigA, SigA" /TUshortPSig="0.977, 0.548, 0.973, 1, 0.994" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S573" CDS 1529267..1529347 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for normal spore cortex and coatsynthesis (stage V sporulation)" /protein_id="NP_389463.1" /db_xref="EnsemblGenomes-Gn:BSU15810" /db_xref="EnsemblGenomes-Tr:CAB13454" /db_xref="GOA:P37817" /db_xref="InterPro:IPR012609" /db_xref="PDB:2MVH" /db_xref="PDB:2MVJ" /db_xref="SubtiList:BG10776" /db_xref="UniProtKB/Swiss-Prot:P37817" /translation="MKFYTIKLPKFLGGIVRAMLGSFRKD*" /label="spoVM CDS" gene 1529267..1529347 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /label="spoVM gene" downshifts 1529362 /Source="Nicolas_upshifts" /id="D879" /incds=0 /nref=178 /ntot=258 /MaxReadThrough="4.05442" /MaxDrop="7.745" /score="7.47691609" /energy="-16.9" /TU="U1301,U1302" /idTUdmin="U1295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1529407..1529779 /Source="Nicolas_S_feature" /locus_tag="new_1655586_1655958" /HighExp="S4, S5, T5.0H, S3, S6, S8, S7, T4.0H, LoTm, T3.30H" /AntisenseName="rpmB" /AntisenseCor="-0.40376097579549802" /AntisenseRegPval="-11.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.977, 0.548" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S574" CDS complement(1529420..1529608) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8722036; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L28" /protein_id="NP_389464.1" /db_xref="EnsemblGenomes-Gn:BSU15820" /db_xref="EnsemblGenomes-Tr:CAB13455" /db_xref="GOA:P37807" /db_xref="InterPro:IPR001383" /db_xref="InterPro:IPR026569" /db_xref="InterPro:IPR034704" /db_xref="InterPro:IPR037147" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10777" /db_xref="UniProtKB/Swiss-Prot:P37807" /translation="MARKCVITGKKTTAGNNRSHAMNASKRTWGANLQKVRILVNGKP KKVYVSARALKSGKVERV*" /label="rpmB CDS" gene complement(1529420..1529608) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /label="rpmB gene" downshifts complement(1529436) /Source="Nicolas_upshifts" /id="D880" /incds=0 /nref=216 /ntot=298 /MaxReadThrough="2.59598" /MaxDrop="7.48719" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" downshifts complement(1529482) /Source="Nicolas_upshifts" /id="D881" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="7.6779" /MaxDrop="3.1786" /score="15.2403969" /energy="-14.3" /TU="U1303" /idTUdmin="U1303" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(1529609..1529701) /Source="Nicolas_S_feature" /locus_tag="new_1655788_1655880_c" /HighExp="HPh, LPh, HiOs, LBGexp, aero, G180, GM 15, dia0, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S575" promotor_-10 complement(1529683..1529702) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1529701) /Source="Nicolas_upshifts" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1529718..1529721) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1529752..1529759 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1529774..1529792 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1529781 /Source="Nicolas_upshifts" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" promotor_-35 1529820..1529823 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1529838..1529857 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1529846 /Source="Nicolas_upshifts" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" CDS 1529885..1530247 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 17114254, 24178028, 28579978; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor involved in malonyl-CoA synthesis" /protein_id="NP_389465.1" /db_xref="EnsemblGenomes-Gn:BSU15830" /db_xref="EnsemblGenomes-Tr:CAB13456" /db_xref="InterPro:IPR005531" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG13395" /db_xref="UniProtKB/Swiss-Prot:O34318" /translation="MSIELRTKYGQIDISNEVIAMVAGGAAVDCYGIVGMASKNQIKD GLTEILRKENFSRGVQVRQEGEQIHIDMYIIVSYGTKISEVAHNVQTKVKYTVNQTIG LAVDSVNIYVQGVRVTNP*" /label="yloU CDS" gene 1529885..1530247 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /label="yloU gene" downshifts complement(1530098) /Source="Nicolas_upshifts" /id="D882" /incds=1 /nref=1 /ntot=143 /MaxReadThrough="1.75412" /MaxDrop="2.71497" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1530263..1531924 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16647083, 22333191, 22517742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme structurally related to dihydroxyacetone/glyceraldehyde kinase" /protein_id="NP_389466.1" /db_xref="EnsemblGenomes-Gn:BSU15840" /db_xref="EnsemblGenomes-Tr:CAB13457" /db_xref="GOA:O34751" /db_xref="InterPro:IPR004007" /db_xref="InterPro:IPR019986" /db_xref="InterPro:IPR033470" /db_xref="InterPro:IPR036117" /db_xref="SubtiList:BG13396" /db_xref="UniProtKB/Swiss-Prot:O34751" /translation="MSIRTLDGRTFAEMILAGAQNLSQNASAVDALNVFPVPDGDTGT NMNLSMTSGAREVEQMDTDDIGKVGSALSKGLLMGARGNSGVILSQLFRGFSKNIETK KEINALEFAAALQAGVDMAYKAVMKPVEGTILTVAKDAAKKAMILAEKETDITALMTA VTEEAEASLNRTPELLPVLKEVGVVDSGGKGLLCVYEGFLASLKGETVPQKAVLPSLD DMVSAEHHKSAQSMMNTEDIEFGFCTEVMVRLDQTKREFDEGTFRQDLSQFGDSLLVI ADESLAKVHIHAEEPGNVLNYAQHYGELIKIKIENMREQHTSIISQESKPADNETPPA KQPYGIVTVAMGEGIADLFKSIGASVVIEGGQTMNPSTEDIVDAVKSVNADTVFILPN NSNIIMAANQAASVVDEQVFVIPAKTVPQGMSALLAFNPDQEAEANEANMLSAIQQVK SGQVTFSVRDTHIDGKDIKKGDFMGILNGTIIGTSENQLSAAKMLLSEMIGEDDEIVT ILYGEDASQEEAEQLEAFLSEKYEEIEVEIHNGKQPLYSYIVSAE*" /label="yloV CDS" gene 1530263..1531924 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /label="yloV gene" S_feature 1531925..1532014 /Source="Nicolas_S_feature" /locus_tag="new_1658104_1658193" /HighExp="G135, G180, G150, LBGexp, Oxctl, Paraq, dia0, LPh, Lbexp, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37023200000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.991, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S576" promotor_-35 1531987..1531994 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-35" promotor_-10 1532008..1532027 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-10" upshifts 1532016 /Source="Nicolas_upshifts" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="upshifts" CDS 1532063..1532725 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8385012, 9244285, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385012, 9244285, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (beta chain)" /protein_id="NP_389467.1" /db_xref="EnsemblGenomes-Gn:BSU15850" /db_xref="EnsemblGenomes-Tr:CAB13458" /db_xref="GOA:O34635" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004643" /db_xref="InterPro:IPR005131" /db_xref="InterPro:IPR029009" /db_xref="SubtiList:BG13397" /db_xref="UniProtKB/Swiss-Prot:O34635" /translation="MKYRSVFDIIGPVMIGPSSSHTAGAARIGRVARSLFGREPERII VSFYGSFAETYKGHGTDVAIIGGLLDFDTFDERIKTAIQIAEAKGIDIEFRVEDAVPV HPNTAKITISDEKGELELTGISIGGGKIEITELNGFELRLSGNHPAILVVHNDKFGTI AGVANVLAKFSINVGHMEVARKDIGQLALMTIEVDQNIDDHILDELSKLPNIIQVTKI AD*" /label="sdaAB CDS" gene 1532063..1532725 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /label="sdaAB gene" CDS 1532751..1533653 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2504697, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2504697, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (alpha chain)" /protein_id="NP_389468.1" /db_xref="EnsemblGenomes-Gn:BSU15860" /db_xref="EnsemblGenomes-Tr:CAB13459" /db_xref="GOA:O34607" /db_xref="InterPro:IPR004642" /db_xref="InterPro:IPR005130" /db_xref="SubtiList:BG13398" /db_xref="UniProtKB/Swiss-Prot:O34607" /translation="MFRNVKELIEITKEKQILISDVMIAQEMEVTEKTKEDIFQQMDH NLSVMEAAVQKGLEGVTSQTGLTGGDAVKLQAYIRSGKSLSGPLILDAVSKAVATNEV NAAMGTICATPTAGSAGVVPGTLFAVKEKLNPTREQMIRFLFTAGAFGFVVANNASIS GAAGGCQAEVGSASGMAAAAIVEMAGGTPEQSAEAMAITLKNMLGLVCDPVAGLVEVP CVKRNAMGASNAMIAADMALAGITSRIPCDEVIDAMYKIGQTMPTALRETGQGGLAAT PTGRELEKKIFGGALGSRETTSAN*" /label="sdaAA CDS" gene 1532751..1533653 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /label="sdaAA gene" CDS 1533631..1535679 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branch migrating ATP-dependent DNA helicase involved in DNA recombination and repair" /protein_id="NP_389469.1" /db_xref="EnsemblGenomes-Gn:BSU15870" /db_xref="EnsemblGenomes-Tr:CAB13460" /db_xref="GOA:O34942" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR004609" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033454" /db_xref="SubtiList:BG13399" /db_xref="UniProtKB/Swiss-Prot:O34942" /translation="MKQHQQTSIANIKGIGPETEKTLNELGIYDISDLLNYFPYRYDD YELRDLEEVKHDERVTVEGKVHSEPSLTYYGKKRNRLTFRLLVGHYLITAVCFNRPYL KKKLSLGSVVTVSGKWDKHRQTISVQELKNGPHQEDKSIEPVYSVKENVTVKMMRRFI QQALTQYADSLPDPLPEKLRKSYKLPDYYQALKAMHQPETREALKLARRRFVYEEFLL FQLKMQAFRKAEREQTQGIRQRFSNEELMRFIKSLPFPLTNAQSRVLREITADMSSPY RMNRLLQGDVGSGKTAVAAIALYAAILSGYQGALMVPTEILAEQHADSLVSLFEKWDV SVALLTSSVKGKRRKELLERLAAGEIDILVGTHALIQDEVEFKALSLVITDEQHRFGV EQRKKLRNKGQDPDVLFMTATPIPRTLAITVFGEMDVSVIDEMPAGRKRIETYWVKHD MLDRILAFVEKELKQGRQAYIICPLIEESDKLDVQNAIDVYNMLSDIFRGKWNVGLMH GKLHSDEKDQVMREFSANHCQILVSTTVVEVGVNVPNATIMVIYDADRFGLSQLHQLR GRVGRGEHQSFCILMADPKSETGKERMRIMSETNDGFELSEKDLELRGPGDFFGKKQS GMPEFKVADMVHDYRALETARQDAANLVASDAFWKEPEYAVLRDELLKSGVMDGEKLS *" /label="recG CDS" gene 1533631..1535679 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /label="recG gene" promotor_-35 1535715..1535722 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1535737..1535756 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1535743 /Source="Nicolas_upshifts" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1535788..1536354 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12737802, 17962296, 20201588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12737802, 17962296, 20201588, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription factor controlling fatty acid and phospholipid metabolism (FapR-malonyl-Coa)" /protein_id="NP_389470.1" /db_xref="EnsemblGenomes-Gn:BSU15880" /db_xref="EnsemblGenomes-Tr:CAB13461" /db_xref="GOA:O34835" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR017275" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="PDB:2F3X" /db_xref="PDB:2F41" /db_xref="SubtiList:BG13400" /db_xref="UniProtKB/Swiss-Prot:O34835" /translation="MRRNKRERQELLQQTIQATPFITDEELAGKFGVSIQTIRLDRLE LSIPELRERIKNVAEKTLEDEVKSLSLDEVIGEIIDLELDDQAISILEIKQEHVFSRN QIARGHHLFAQANSLAVAVIDDELALTASADIRFTRQVKQGERVVAKAKVTAVEKEKG RTVVEVNSYVGEEIVFSGRFDMYRSKHS*" /label="fapR CDS" gene 1535788..1536354 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /label="fapR gene" CDS 1536368..1537369 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphate:acyl-ACP acyltransferase" /protein_id="NP_389471.1" /db_xref="EnsemblGenomes-Gn:BSU15890" /db_xref="EnsemblGenomes-Tr:CAB13462" /db_xref="GOA:P71018" /db_xref="InterPro:IPR003664" /db_xref="InterPro:IPR012281" /db_xref="PDB:1VI1" /db_xref="SubtiList:BG11843" /db_xref="UniProtKB/Swiss-Prot:P71018" /translation="MRIAVDAMGGDHAPKAVIDGVIKGIEAFDDLHITLVGDKTTIES HLTTTSDRITVLHADEVIEPTDEPVRAVRRKKNSSMVLMAQEVAENRADACISAGNTG ALMTAGLFIVGRIKGIDRPALAPTLPTVSGDGFLLLDVGANVDAKPEHLVQYAIMGSV YSQQVRGVTSPRVGLLNVGTEDKKGNELTKQTFQILKETANINFIGNVEARDLLDDVA DVVVTDGFTGNVTLKTLEGSALSIFKMMRDVMTSTLTSKLAAAVLKPKLKEMKMKMEY SNYGGASLFGLKAPVIKAHGSSDSNAVFHAIRQAREMVSQNVAALIQEEVKEEKTDE* " /label="plsX CDS" gene 1536368..1537369 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /label="plsX gene" CDS 1537388..1538341 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /EC_number="2.3.1.39" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586097, 19850612" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586097, 19850612; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malonyl CoA:acyl carrier protein transacylase" /protein_id="NP_389472.1" /db_xref="EnsemblGenomes-Gn:BSU15900" /db_xref="EnsemblGenomes-Tr:CAB13463" /db_xref="GOA:P71019" /db_xref="InterPro:IPR004410" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="InterPro:IPR024925" /db_xref="SubtiList:BG11836" /db_xref="UniProtKB/Swiss-Prot:P71019" /translation="MSKIAFLFPGQGSQFIGMGKELYEQVPAAKRLFDEADETLETKL SSLIFEGDAEELTLTYNAQPALLTTSIAVLEKFKESGITPDFTAGHSLGEYSALVAAG ALSFKDAVYTVRKRGEFMNEAVPAGEGAMAAILGMDAEALKQVTDKVTEEGNLVQLAN LNCPGQIVISGTAKGVELASELAKENGAKRAIPLEVSGPFHSELMKPAAEKLKEVLDA CDIKDADVPVISNVSADVMTEKADIKEKLIEQLYSPVRFEESINKLIAEGVTTFIEIG PGKVLSGLVKKVNRRLKTIAVSDPETIELAIQTLKEENDNA*" /label="fabD CDS" gene 1537388..1538341 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /label="fabD gene" CDS 1538334..1539074 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /EC_number="1.1.1.100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12655455, 12682299, 19850612, 28126742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12655455, 12682299, 19850612, 28126742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein reductase" /protein_id="NP_389473.1" /db_xref="EnsemblGenomes-Gn:BSU15910" /db_xref="EnsemblGenomes-Tr:CAB13464" /db_xref="GOA:P51831" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011284" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11535" /db_xref="UniProtKB/Swiss-Prot:P51831" /translation="MLNDKTAIVTGASRGIGRSIALDLAKSGANVVVNYSGNEAKANE VVDEIKSMGRKAIAVKADVSNPEDVQNMIKETLSVFSTIDILVNNAGITRDNLIMRMK EDEWDDVININLKGVFNCTKAVTRQMMKQRSGRIINVSSIVGVSGNPGQANYVAAKAG VIGLTKSSAKELASRNITVNAIAPGFISTDMTDKLAKDVQDEMLKQIPLARFGEPSDV SSVVTFLASEGARYMTGQTLHIDGGMVM*" /label="fabG CDS" gene 1538334..1539074 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /label="fabG gene" promotor_-35 1539105..1539109 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1539125..1539144 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1539130 /Source="Nicolas_upshifts" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1539158..1539391 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 19850612, 27467752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 19850612, 27467752; Product type c: carrier" /codon_start=1 /transl_table=11 /product="acyl carrier protein" /protein_id="NP_389474.1" /db_xref="EnsemblGenomes-Gn:BSU15920" /db_xref="EnsemblGenomes-Tr:CAB13465" /db_xref="GOA:P80643" /db_xref="InterPro:IPR003231" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:1F80" /db_xref="PDB:1HY8" /db_xref="PDB:2X2B" /db_xref="SubtiList:BG11536" /db_xref="UniProtKB/Swiss-Prot:P80643" /translation="MADTLERVTKIIVDRLGVDEADVKLEASFKEDLGADSLDVVELV MELEDEFDMEISDEDAEKIATVGDAVNYIQNQQ*" /label="acpA CDS" gene 1539158..1539391 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /label="acpA gene" downshifts 1539372 /Source="Nicolas_upshifts" /id="D883" /incds=0 /nref=22 /ntot=197 /MaxReadThrough="8.12206" /MaxDrop="4.1545" /score="-8.42930766" /energy="-17.4" /TU="U1306,U1307,U1308" /idTUdmin="U1306" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" promotor_no_box 1539400..1539500 /Source="Nicolas_upshift_promotors" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 1539460..1539530 /Source="Nicolas_S_feature" /locus_tag="new_1665639_1665709" /HighExp="LBGstat, dia5, Cold, LBGtran, C30, Diami, G135, LBGexp, G/S, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA, SigA" /TUshortPSig="0.031, 1, 1, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="0.991, 0.991" /label="S577" upshifts 1539460 /Source="Nicolas_upshifts" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1539531..1540280 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /EC_number="3.1.26.3" /experiment="publication(s) with functional evidences, PMID:11123676, 12682299, 16179796, 22412379, 23300471, 26883633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11123676, 12682299, 16179796, 22412379, 23300471, 26883633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease III" /protein_id="NP_389475.1" /db_xref="EnsemblGenomes-Gn:BSU15930" /db_xref="EnsemblGenomes-Tr:CAB13466" /db_xref="GOA:P51833" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR011907" /db_xref="InterPro:IPR014720" /db_xref="InterPro:IPR036389" /db_xref="SubtiList:BG11537" /db_xref="UniProtKB/Swiss-Prot:P51833" /translation="MSKHSHYKDKKKFYKKVEQFKEFQERISVHFQNEKLLYQAFTHS SYVNEHRKKPYEDNERLEFLGDAVLELTISRFLFAKYPAMSEGDLTKLRAAIVCEPSL VSLAHELSFGDLVLLGKGEEMTGGRKRPALLADVFEAFIGALYLDQGLEPVESFLKVY VFPKINDGAFSHVMDFKSQLQEYVQRDGKGSLEYKISNEKGPAHNREFEAIVSLKGEP LGVGNGRSKKEAEQHAAQEALAKLQKHHTKQ*" /label="rnc CDS" gene 1539531..1540280 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /label="rnc gene" downshifts 1540252 /Source="Nicolas_upshifts" /id="D884" /incds=0 /nref=78 /ntot=211 /MaxReadThrough="6.42554" /MaxDrop="5.70849" /score="-8.42930766" /energy="-17.4" /TU="U1307,U1308,U1309" /idTUdmin="U1306" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1540322..1540328 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1540340..1540359 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1540362 /Source="Nicolas_upshifts" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1540381..1543941 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation SMC ATPase" /protein_id="NP_389476.2" /db_xref="EnsemblGenomes-Gn:BSU15940" /db_xref="EnsemblGenomes-Tr:CAB13467" /db_xref="GOA:P51834" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR010935" /db_xref="InterPro:IPR011890" /db_xref="InterPro:IPR024704" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036277" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5NMO" /db_xref="PDB:5NNV" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG11538" /db_xref="UniProtKB/Swiss-Prot:P51834" /translation="MFLKRLDVIGFKSFAERISVDFVKGVTAVVGPNGSGKSNITDAI RWVLGEQSARSLRGGKMEDIIFAGSDSRKRLNLAEVTLTLDNDDHFLPIDFHEVSVTR RVYRSGESEFLINNQPCRLKDIIDLFMDSGLGKEAFSIISQGKVEEILSSKAEDRRSI FEEAAGVLKYKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDYLEK KKELEHVEIALTAYDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKI QALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETV LKEELSKQEAVFETLQAEVKQLRAQVKEKQQALSLHNENVEEKIEQLKSDYFELLNSQ ASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHS QVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGDFSGFYQGVK EVLKAKERLGGIRGAVLELISTEQKYETAIEIALGASAQHVVTDDEQSARKAIQYLKQ NSFGRATFLPLSVIRDRQLQSRDAETAARHSSFLGVASELVTFDPAYRSVIQNLLGTV LITEDLKGANELAKLLGHRYRIVTLEGDVVNPGGSMTGGAVKKKNNSLLGRSRELEDV TKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQV AEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQK QTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSF LTSEMSSSTSGEEKLEEAAKHKLNDKTKTIELIALRRDQRIKLQHGLDTYERELKEMK RLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKR VKLIKLAIEELGTVNLGSIDEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMDEEMT KRFNDTFVQIRSHFDQVFRSLFGGGRAELRLTDPNDLLHSGVEIIAQPPGKKLQNLNL LSGGERALTAIALLFSILKVRPVPFCVLDEVEAALDEANVFRFAQYLKKYSSDTQFIV ITHRKGTMEEADVLYGVTMQESGVSKVISVKLEETKEFVQ*" /label="smc CDS" gene 1540381..1543941 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /label="smc gene" S_feature complement(1543875..1544945) /Source="Nicolas_S_feature" /locus_tag="new_1670054_1671124_c" /HighExp="Cold, C30, Gly, T0.30H, Pyr, T-4.40H, G135, Lbstat, Fru, T-5.40H" /AntisenseName="ftsY" /AntisenseCor="-3.7172405649441298E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S578" CDS 1543961..1544950 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal recognition particle (docking protein)" /protein_id="NP_389477.1" /db_xref="EnsemblGenomes-Gn:BSU15950" /db_xref="EnsemblGenomes-Tr:CAB13468" /db_xref="GOA:P51835" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004390" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036225" /db_xref="SubtiList:BG11539" /db_xref="UniProtKB/Swiss-Prot:P51835" /translation="MSFFKKLKEKITKQTDSVSEKFKDGLEKTRNSFQNKVNDLVSRY RKVDEDFFEELEEVLISADVGFTTVMELIDELKKEVKRRNIQDPKEVQSVISEKLVEI YNSGDEQISELNIQDGRLNVILLVGVNGVGKTTTIGKLAHKMKQEGKSVVLAAGDTFR AGAIEQLEVWGERTGVPVIKQTAGSDPAAVIYDAVHAAKARNADVLICDTAGRLQNKV NLMKELEKVKRVIEREVPEAPHEVLLALDATTGQNAMAQAKEFSKATNVTGIALTKLD GTAKGGIVLAIRNELHIPVKLVGLGEKVDDLQEFDPESYVYGLFSDLVEKADD*" /label="ftsY CDS" gene 1543961..1544950 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /label="ftsY gene" downshifts 1544937 /Source="Nicolas_upshifts" /id="D885" /incds=0 /nref=220 /ntot=261 /MaxReadThrough="2.98458" /MaxDrop="6.84303" /score="49.5808683" /energy="-14.4" /TU="NA" /idTUdmin="U1307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1544987..1545472) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535, 22287527" /codon_start=1 /transl_table=11 /product="conserved exported protein of unknown function" /protein_id="NP_389478.1" /db_xref="EnsemblGenomes-Gn:BSU15960" /db_xref="EnsemblGenomes-Tr:CAB13469" /db_xref="GOA:O31737" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="SubtiList:BG13401" /db_xref="UniProtKB/Swiss-Prot:O31737" /translation="MKKIGLLFMLCLAALFTIGFPAQQADAAEAPYKASITNISTDGG VYGKINYGQGQYWRVKYNITVSGKLLDQNGQPVPNAPVRFEADTKVGNTTQTASGTTD ANGTFEVPMYLGPAAGYYTYYTSVSVHYYDIIPFRVFSGESRLVSTDNSLYHFAYQVR R*" /label="ylqB CDS" gene complement(1544987..1545472) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /label="ylqB gene" downshifts complement(1544990) /Source="Nicolas_upshifts" /id="D886" /incds=0 /nref=139 /ntot=244 /MaxReadThrough="6.77251" /MaxDrop="6.10895" /score="32.8428224" /energy="-14.4" /TU="U1311" /idTUdmin="U1311" /TUdmin="-1076" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1545494..1545512) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1545510) /Source="Nicolas_upshifts" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1545526..1545533) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1545575..1545581 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1545596..1545615 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1545598 /Source="Nicolas_upshifts" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1545649..1545981 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11274114, 24659773; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the signal recognition particle (SRP) protein-targeting pathway" /protein_id="NP_389479.1" /db_xref="EnsemblGenomes-Gn:BSU15970" /db_xref="EnsemblGenomes-Tr:CAB13470" /db_xref="GOA:P37104" /db_xref="InterPro:IPR007394" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10829" /db_xref="UniProtKB/Swiss-Prot:P37104" /translation="MSLEKTTRMNYLFDFYQSLLTSKQKSYMSLYYLDDFSLGEIAEE YEVSRQAVYDNIKRTEAMLEQYEEKLLLLKKFQERKEMFNKLKELASGSKEEEEITAL IEALEKLD*" /label="ylxM CDS" gene 1545649..1545981 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /label="ylxM gene" downshifts complement(1545652) /Source="Nicolas_upshifts" /id="D887" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="1.40385" /MaxDrop="4.6092" /score="32.8428224" /energy="-14.4" /TU="NA" /idTUdmin="U1311" /TUdmin="-1738" /isTUend="FALSE" /label="downshifts" CDS 1545995..1547335 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal recognition particle-like (SRP) GTPase" /protein_id="NP_389480.1" /db_xref="EnsemblGenomes-Gn:BSU15980" /db_xref="EnsemblGenomes-Tr:CAB13471" /db_xref="GOA:P37105" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004125" /db_xref="InterPro:IPR004780" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR022941" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036891" /db_xref="PDB:4UE4" /db_xref="SubtiList:BG10830" /db_xref="UniProtKB/Swiss-Prot:P37105" /translation="MAFEGLADRLQQTISKIRGKGKVSEQDVKEMMREVRLALLEADV NFKVVKDFVKKVSERAVGQDVMKSLTPGQQVIKVVQEELTELMGGEESKIAVAKRPPT VIMMVGLQGAGKTTTSGKLANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPV FSLGDQVSPVEIAKQAIEKAKEEHYDYVILDTAGRLHIDHELMDELTNVKEIANPEEI FLVVDSMTGQDAVNVAKSFNEQLGLTGVVLTKLDGDTRGGAALSIRAVTNTPIKFAGL GEKLDALEPFHPERMASRILGMGDVLTLIEKAQASVDEDKAKELEQKMRTMSFTLDDF LEQLGQVRNMGPLDELLQMMPGAGKMKGLKNIQVDEKQLNHVEAIIKSMTVLEKEQPD IINASRRKRIAKGSGTSVQEVNRLLKQFDEMKKMMKQMTNMSKGKKKGFKLPFM*" /label="ffh CDS" gene 1545995..1547335 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /label="ffh gene" S_feature 1547336..1547440 /Source="Nicolas_S_feature" /locus_tag="new_1673515_1673619" /HighExp="Cold, G135, C30, G180, LPhT, HPh, Paraq, LPh, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S579" CDS 1547441..1547713 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6419023, 12682299, 20034956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6419023, 12682299, 20034956; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S16 (BS17)" /protein_id="NP_389481.1" /db_xref="EnsemblGenomes-Gn:BSU15990" /db_xref="EnsemblGenomes-Tr:CAB13472" /db_xref="GOA:P21474" /db_xref="InterPro:IPR000307" /db_xref="InterPro:IPR020592" /db_xref="InterPro:IPR023803" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10831" /db_xref="UniProtKB/Swiss-Prot:P21474" /translation="MAVKIRLKRMGAKKSPFYRIVVADSRSPRDGRFIETVGTYNPVA KPAEVKIDEELALKWLQTGAKPSDTVRNLFSSQGIMEKFHNAKQGK*" /label="rpsP CDS" gene 1547441..1547713 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /label="rpsP gene" CDS 1547713..1547958 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735, 26483775; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_389482.1" /db_xref="EnsemblGenomes-Gn:BSU16000" /db_xref="EnsemblGenomes-Tr:CAB13473" /db_xref="GOA:O31738" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020627" /db_xref="SubtiList:BG13402" /db_xref="UniProtKB/Swiss-Prot:O31738" /translation="MTDQHLEDLIVHIVTPLVDHPDDIRVIREETDQKIALRLSVHKS DTGKVIGKQGRTAKAIRTAVFAAGVQSSKKVQFEIFD*" /label="ylqC CDS" gene 1547713..1547958 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /label="ylqC gene" downshifts 1547930 /Source="Nicolas_upshifts" /id="D888" /incds=0 /nref=41 /ntot=178 /MaxReadThrough="6.57974" /MaxDrop="4.803" /score="-7.01631592" /energy="-5.6" /TU="U1312" /idTUdmin="U1312" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" S_feature 1547975..1548079 /Source="Nicolas_S_feature" /locus_tag="new_1674154_1674258" /HighExp="G180, Oxctl, G150, G135, Paraq, LBGexp, H2O2, HPh, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S580" CDS 1548080..1548466 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389483.1" /db_xref="EnsemblGenomes-Gn:BSU16010" /db_xref="EnsemblGenomes-Tr:CAB13474" /db_xref="InterPro:IPR021297" /db_xref="SubtiList:BG13403" /db_xref="UniProtKB/Swiss-Prot:O31739" /translation="MQIIHRVAVMQVLTERSKEKLLASFAEKKQMLERECSQLYFQLR KHEKEQQNPNMIEQFKKAIEKRKDDIKIIDFQIAQVHTLPLGSELKEKEVDALLTIEA GDDWHEKTAANTIVIKDGKVIEIRQR*" /label="ylqD CDS" gene 1548080..1548466 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /label="ylqD gene" CDS 1548471..1548995 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15496525, 16014871, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="16S rRNA processing protein" /protein_id="NP_389484.1" /db_xref="EnsemblGenomes-Gn:BSU16020" /db_xref="EnsemblGenomes-Tr:CAB13475" /db_xref="GOA:O31740" /db_xref="InterPro:IPR002676" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR011961" /db_xref="InterPro:IPR027275" /db_xref="InterPro:IPR036976" /db_xref="SubtiList:BG13404" /db_xref="UniProtKB/Swiss-Prot:O31740" /translation="MTKRWFNVGKIVNTHGIKGEVRVISKTDFAEERYKPGNTLYLFM DGRNEPVEVTVNTHRLHKQFHLLQFKERQNLNEVEELKNAIIKVPEEELGELNEGEFY FHEIIGCEVFTEEGELIGKVKEILTPGANDVWVIGRKGKKDALIPYIESVVKHIDVRE KKIEIELMEGLIDE*" /label="rimM CDS" gene 1548471..1548995 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /label="rimM gene" CDS 1548992..1549723 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /EC_number="2.1.1.228" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094308, 11532950, 12682299, 12773376, 15060037, 27881678, 28601227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(m1G37)methyltransferase" /protein_id="NP_389485.1" /db_xref="EnsemblGenomes-Gn:BSU16030" /db_xref="EnsemblGenomes-Tr:CAB13476" /db_xref="GOA:O31741" /db_xref="InterPro:IPR002649" /db_xref="InterPro:IPR016009" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG12687" /db_xref="UniProtKB/Swiss-Prot:O31741" /translation="MKIDFLTLFPEMFEGVLGSSILQKAQEKDAVQFQVVNFREYSDN KHNTVDDYPYGGGAGMVLKPQPVFDAVEDLTSKAAAAPRIILVCPQGERFTQKKAEQL AKEEHLLFICGHYEGYDERIREHLVTDEISIGDFVLTGGELPAMMIADSVVRLLPGVL GKEASHIEDSFSTGLLEHPHYTRPADYKGLKVPETLLSGNHAKIEEWRNKESIRRTYL RRPDLLKDHPLTEQQRKWISEWEKE*" /label="trmD CDS" gene 1548992..1549723 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /label="trmD gene" promotor_-35 1549729..1549736 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1549750..1549769 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1549754 /Source="Nicolas_upshifts" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" misc_RNA 1549802..1549843 /locus_tag="BSU_misc_RNA_30" /product="L19_leader" /label="L19 leader RNA" gene 1549802..1549843 /locus_tag="BSU_misc_RNA_30" /label="gene" CDS 1549863..1550210 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16272117, 27477481; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L19" /protein_id="NP_389486.2" /db_xref="EnsemblGenomes-Gn:BSU16040" /db_xref="EnsemblGenomes-Tr:CAB13477" /db_xref="GOA:O31742" /db_xref="InterPro:IPR001857" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR018257" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12667" /db_xref="UniProtKB/Swiss-Prot:O31742" /translation="MQKLIEDITKEQLRTDLPAFRPGDTLRVHVKVVEGNRERIQIFE GVVIKRRGGGISETFTVRKISYGVGVERTFPVHTPKIAKIEVVRYGKVRRAKLYYLRE LRGKAARIKEIRR*" /label="rplS CDS" gene 1549863..1550210 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /label="rplS gene" downshifts 1550212 /Source="Nicolas_upshifts" /id="D889" /incds=0 /nref=212 /ntot=274 /MaxReadThrough="6.00308" /MaxDrop="9.06015" /score="23.9942041" /energy="-12.6" /TU="U1313" /idTUdmin="U1312" /TUdmin=478 /isTUend="FALSE" /label="downshifts" promotor_-35 1550265..1550271 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1550284..1550352 /Source="Nicolas_S_feature" /locus_tag="new_1676463_1676531" /HighExp="Oxctl, G180, Paraq, G135, H2O2, LBGstat, dia15, G150, HPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.149563" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S581" upshifts 1550284 /Source="Nicolas_upshifts" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1550285..1550304 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1550353..1551201 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome biogenesis GTPase A" /protein_id="NP_389487.1" /db_xref="EnsemblGenomes-Gn:BSU16050" /db_xref="EnsemblGenomes-Tr:CAB13478" /db_xref="GOA:O31743" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016478" /db_xref="InterPro:IPR019991" /db_xref="InterPro:IPR023179" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="PDB:1PUJ" /db_xref="SubtiList:BG13405" /db_xref="UniProtKB/Swiss-Prot:O31743" /translation="MTIQWFPGHMAKARREVTEKLKLIDIVYELVDARIPMSSRNPMI EDILKNKPRIMLLNKADKADAAVTQQWKEHFENQGIRSLSINSVNGQGLNQIVPASKE ILQEKFDRMRAKGVKPRAIRALIIGIPNVGKSTLINRLAKKNIAKTGDRPGITTSQQW VKVGKELELLDTPGILWPKFEDELVGLRLAVTGAIKDSIINLQDVAVFGLRFLEEHYP ERLKERYGLDEIPEDIAELFDAIGEKRGCLMSGGLINYDKTTEVIIRDIRTEKFGRLS FEQPTM*" /label="rbgA CDS" gene 1550353..1551201 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /label="rbgA gene" promotor_-35 1551222..1551229 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1551242..1551260 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1551252 /Source="Nicolas_upshifts" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1551272..1552039 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /EC_number="3.1.26.4" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10094689, 12475934, 23882084, 23937561, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094689, 12475934, 23882084, 23937561, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HII" /protein_id="NP_389488.1" /db_xref="EnsemblGenomes-Gn:BSU16060" /db_xref="EnsemblGenomes-Tr:CAB13479" /db_xref="GOA:O31744" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR022898" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12666" /db_xref="UniProtKB/Swiss-Prot:O31744" /translation="MNTLTVKDIKDRLQEVKDAQDPFIAQCENDPRKSVQTLVEQWLK KQAKEKALKEQWVNMTSYERLARNKGFRLIAGVDEVGRGPLAGPVVASAVILPEECEI LGLTDSKKLSEKKREEYYELIMKEALAVGIGIVEATVIDEINIYEASKMAMVKAIQDL SDTPDYLLVDAMTLPLDTAQASIIKGDAKSVSIAAGACIAKVTRDRMMSAYAETYPMY GFEKNKGYGTKEHLEALAAYGPTELHRKTFAPVQSFR*" /label="rnhB CDS" gene 1551272..1552039 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /label="rnhB gene" CDS 1552071..1553801 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389489.1" /db_xref="EnsemblGenomes-Gn:BSU16070" /db_xref="EnsemblGenomes-Tr:CAB13480" /db_xref="SubtiList:BG13406" /db_xref="UniProtKB/Swiss-Prot:O31745" /translation="MNIRNDVQKALQHLFGRTAVPQETSKVNEALNGEKRLLLGKVLR LLGDQHALIQVGNQTVQGKLETQLRPQAYYWFSYEKKTAEQTGRLQVVQSFDQNPKTI QDAAGKLLNAISVKTSNAALMMTGAMLKSKTPVTENDIKTAVRWMDTLPSQDTKKAVE TVLFALKRDLPIHSEILNGVHAVKSPVPLHQHVSQLLQAIDQNPQQSQMMSKLKEAVT VLLNSEIDVHAERLIDKLISLTDNTKAPSPTNTAGSRELSTPAGSPGKASLPIANHTA EQGSIQEEPVKTAADIPIKEARQLLVKLTESAEKNSLQIVKEAANWIKAAASSGDSKS LAASAVLQAAQVTDQEAEVFLKAVQQTAPHLADKADVLSFLSKVKTAIGARDEVAFIK AFEQGSAVTSGEMQSIKLALSALRASHEVAEPVKQEADQLFHKLNGQLFMQQDHPSYS QIVMSFPMFSKSGVQDMTVLFKGKKEADGKLDPSHCRLLFLLQLDTLKETVVDCLVQQ KVMTITIETDFELQAAIDPMVPALKQGLKEMGYSLSGVNAKKRVHTEEKASIDQYITS ISDQEVDVKI*" /label="ylqG CDS" gene 1552071..1553801 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /label="ylqG gene" upshifts complement(1553308) /Source="Nicolas_upshifts" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1553309..1553328) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1553343..1553350) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1553798..1554079 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative flagellar biosynthesis protein" /protein_id="NP_389490.1" /db_xref="EnsemblGenomes-Gn:BSU16080" /db_xref="EnsemblGenomes-Tr:CAB13481" /db_xref="GOA:O34867" /db_xref="InterPro:IPR004683" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13407" /db_xref="UniProtKB/Swiss-Prot:O34867" /translation="MKEQTPIRKAVALHYDEQKDKAPRVIATGKGHVADNIIKEAKKA GVPIQEDRTLVELMRHLTVDDQIPEALYETVAEIFSFIYKLDESVKNKK*" /label="ylqH CDS" gene 1553798..1554079 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /label="ylqH gene" downshifts 1553911 /Source="Nicolas_upshifts" /id="D890" /incds=1 /nref=7 /ntot=136 /MaxReadThrough="4.03339" /MaxDrop="4.52065" /score="-6.81136789" /energy="-9.2" /TU="U1313,U1315" /idTUdmin="U1313" /TUdmin="-267" /isTUend="FALSE" /label="downshifts" S_feature 1554080..1554199 /Source="Nicolas_S_feature" /locus_tag="new_1680259_1680378" /HighExp="Cold, Lbstat, H2O2, Glu, Paraq, Mal, G135, GM 90, Oxctl, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S582" promotor_-35 1554171..1554178 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1554192..1554211 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1554201 /Source="Nicolas_upshifts" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1554252..1555409 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2548486, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (beta subunit)" /protein_id="NP_389491.1" /db_xref="EnsemblGenomes-Gn:BSU16090" /db_xref="EnsemblGenomes-Tr:CAB13482" /db_xref="GOA:P80886" /db_xref="InterPro:IPR005809" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013650" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017866" /db_xref="SubtiList:BG12680" /db_xref="UniProtKB/Swiss-Prot:P80886" /translation="MNIHEYQGKEVLRKYGVSVPEGKVAFTAEEAVESAKSLSSSVYV VKAQIHAGGRGKAGGVKIAKSLDEVKAYAEELLGKTLVTHQTGPDGQVIKRLLIEEGC DIKKEYYIGLVLDRATSRIVLMASEEGGTEIEEVAEKTPEKIKKAVIDPAVGLQGYQA REIAFAINIPKELVGKAAKFMLGLYKAFVEKDCSIAEINPLVVTGDGNVMALDAKLNF DSNALYRQKDIMEYRDLDEEDPKEIEASKYDLSYISLDGNIGCMVNGAGLAMSTMDII KHYGGEPANFLDVGGGATAEKVTEAFKIILSDQNVKGIFVNIFGGIMKCDVIAEGVVE ATRQVGLTLPLVVRLEGTNVDLGKKILSESGLNITSAESMADGAQKIVSLV*" /label="sucC CDS" gene 1554252..1555409 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /label="sucC gene" promotor_no_box complement(1554324..1554424) /Source="Nicolas_upshift_promotors" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1554364) /Source="Nicolas_upshifts" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1555438..1556340 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9643546, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (alpha subunit)" /protein_id="NP_389492.1" /db_xref="EnsemblGenomes-Gn:BSU16100" /db_xref="EnsemblGenomes-Tr:CAB13483" /db_xref="GOA:P80865" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR005810" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017440" /db_xref="InterPro:IPR033847" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12681" /db_xref="UniProtKB/Swiss-Prot:P80865" /translation="MSVFINKDTRVIVQGITGSTALFHTKQMLEYGTNIVGGVTPGKG GTEAEGVPVFNTVAEAVQTTGANASVIYVPAPFAADAIMEAVDAELDLVICITEHIPV LDMVKVKRFMEGKKTRLIGPNCPGVITPEECKIGIMPGYIHKKGHVGVVSRSGTLTYE AVHQLSEAGVGQSTAVGIGGDPVNGTNFIDVLKAFNEDPDTHAVIMIGEIGGTAEEEA AEWVKANMTKPVVGFIGGKTAPPGKRMGHAGAIISGGKGTADEKIKTLNACGIEVAET PSVMGETLIKVLKEKNLFETCKTH*" /label="sucD CDS" gene 1555438..1556340 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /label="sucD gene" downshifts 1556330 /Source="Nicolas_upshifts" /id="D891" /incds=0 /nref=94 /ntot=208 /MaxReadThrough="5.40077" /MaxDrop="4.8878" /score="9.51199539" /energy="-15" /TU="U1317" /idTUdmin="U1315" /TUdmin=2130 /isTUend="FALSE" /label="downshifts" CDS 1556401..1557294 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA processing Smf single strand binding protein" /protein_id="NP_389493.1" /db_xref="EnsemblGenomes-Gn:BSU16110" /db_xref="EnsemblGenomes-Tr:CAB13484" /db_xref="GOA:P39813" /db_xref="InterPro:IPR003488" /db_xref="SubtiList:BG11006" /db_xref="UniProtKB/Swiss-Prot:P39813" /translation="MDQAAVCLTICRINQLLSPSLLLKWWKADPSMSLTSPVLQTVTR DQIKAAALKNEIEQFYPKLPRVLAAYREQGINTIPISSKQYPFWLKSIYDPPAVLFAK GDMTLLSKGRKIGIVGTRNPTAYGKQVVNHLTKEICRKGWVIVSGLASGIDGMSHAAS IKAKGRTIGVIAGGFQHIYPRENLQLADHMAKHHILLSEHPPETKPQKWHFPMRNRII SGLSEGVIVVQGKEKSGSLITAYQALEQGREVFAVPGSLFDPYAGGPIKLIQQGAKAI WSAEDIFEELPERNVQYTEPF*" /label="dprA CDS" gene 1556401..1557294 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /label="dprA gene" promotor_-35 1557300..1557307 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1557322..1557341 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1557329..1557481 /Source="Nicolas_S_feature" /locus_tag="new_1683508_1683660" /HighExp="dia15, H2O2, G/S, Paraq, Diami, S1, Oxctl, LBGexp, C30, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.111279" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigD, SigA, SigA" /TUlongPSig="1, 1, 1" /label="S583" upshifts 1557329 /Source="Nicolas_upshifts" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1557482..1559557 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /EC_number="5.99.1.2" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9580687, 12682299, 16585761, 23133654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9580687, 12682299, 16585761, 23133654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase I" /protein_id="NP_389494.1" /db_xref="EnsemblGenomes-Gn:BSU16120" /db_xref="EnsemblGenomes-Tr:CAB13485" /db_xref="GOA:P39814" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005733" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013498" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR028612" /db_xref="InterPro:IPR034149" /db_xref="SubtiList:BG11007" /db_xref="UniProtKB/Swiss-Prot:P39814" /translation="MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGV DIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDL NSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKK GLSAGRVQSVALRLIIDREKEINDFKPEEYWTIDGTFLKGQETFEASFFGKNGKKLPL NSEADVKEILSQLKGNQYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMM IAQQLYEGIDLGREGTVGLITYMRTDSTRISNTAVDEAAAFIDQTYGKEFLGGKRKPA KKNENAQDAHEAIRPTSVLRKPSELKAVLGRDQMRLYKLIWERFVASQMAPAVLDTMS VDLTNNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKDRMLPDLQEGDTVLSKDIEPE QHFTQPPPRYTEARLVKTLEERGIGRPSTYAPTLDTIQRRGYVALDNKRFVPTELGQI VLDLIMEFFPEIINVEFTAKMERDLDHVEEGNTEWVKIIDNFYTDFEKRVKKAESEMK EVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPSCGE GNIVERKSKKKRVFYGCDRYPDCEFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVE CDYKEEPQK*" /label="topA CDS" gene 1557482..1559557 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /label="topA gene" downshifts 1559527 /Source="Nicolas_upshifts" /id="D892" /incds=0 /nref=48 /ntot=173 /MaxReadThrough="5.66787" /MaxDrop="4.5486" /score="0.939045188" /energy="-13.2" /TU="U1319" /idTUdmin="U1317" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 1559589..1559594 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1559601 /Source="Nicolas_upshifts" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1559610..1559628 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1559633..1560940 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /EC_number="2.1.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16027442, 21561081, 23095745, 23157377, 27825927, 28745052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16027442, 21561081, 23095745, 23157377, 27825927, 28745052; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA:m(5)U-54 methyltransferase" /protein_id="NP_389495.1" /db_xref="EnsemblGenomes-Gn:BSU16130" /db_xref="EnsemblGenomes-Tr:CAB13486" /db_xref="GOA:P39815" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004417" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11008" /db_xref="UniProtKB/Swiss-Prot:P39815" /translation="MNQQTVNVIGAGLAGSEAAWQLAKRGIQVKLYEMRPVKQTPAHH TDKFAELVCSNSLRSNTLANAVGVLKEEMRALDSAIIAAADECSVPAGGALAVDRHEF AASVTNRVKNHPNVTVINEEVTEIPEGPTIIATGPLTSESLSAQLKELTGEDYLYFYD AAAPIVEKDSLDMDKVYLKSRYDKGEAAYLNCPMTEEEFDRFHEALTSAETVPLKEFE KEIFFEGCMPIEVMAKRGKKTMLFGPMKPVGLEHPVTGKRPYAVVQLRQDDAAGTLYN IVGFQTHLKWGDQKEVLKLIPGLENVEIVRYGVMHRNTFINSPSLLKPTYQFKNRSDL FFAGQMTGVEGYVESAASGLVAGINAAKLVLGEELVIFPQETAIGSMAHYITTTNQKN FQPMNANFGLLKELPVKIKNKKERNEQYANRAIETIQTISKTI*" /label="trmFO CDS" gene 1559633..1560940 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /label="trmFO gene" promotor_-35 1560946..1560950 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1560967..1560986 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1560977 /Source="Nicolas_upshifts" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1561008..1561922 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /function="16.9: Replicate" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11208805, 16553881, 16597952, 21239579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11208805, 16553881, 16597952, 21239579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_389496.1" /db_xref="EnsemblGenomes-Gn:BSU16140" /db_xref="EnsemblGenomes-Tr:CAB13487" /db_xref="GOA:P39776" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011931" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG10965" /db_xref="UniProtKB/Swiss-Prot:P39776" /translation="MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQG INGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALRSFYKFLMREKLIEENPFQLVH LPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITIND VDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMKAKEPHDLLFVNQRG GPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLS STQIYTHVSKEMLRNTYMSHHPRAFKKN*" /label="codV CDS" gene 1561008..1561922 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /label="codV gene" promotor_-35 1561047..1561051 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-35" upshifts 1561064 /Source="Nicolas_upshifts" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="upshifts" promotor_-10 1561067..1561086 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-10" CDS 1561935..1562480 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /EC_number="3.4.25.2" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (N-terminalserine protease)" /protein_id="NP_389497.1" /db_xref="EnsemblGenomes-Gn:BSU16150" /db_xref="EnsemblGenomes-Tr:CAB13488" /db_xref="GOA:P39070" /db_xref="InterPro:IPR001353" /db_xref="InterPro:IPR022281" /db_xref="InterPro:IPR023333" /db_xref="InterPro:IPR029055" /db_xref="PDB:1YYF" /db_xref="PDB:2Z3A" /db_xref="PDB:2Z3B" /db_xref="SubtiList:BG10966" /db_xref="UniProtKB/Swiss-Prot:P39070" /translation="MSSFHATTIFAVQHKGRSAMSGDGQVTFGQAVVMKHTARKVRKL FNGKVLAGFAGSVADAFTLFEKFEAKLEEYNGNLKRAAVELAKEWRSDKVLRKLEAML IVMNQDTLLLVSGTGEVIEPDDGILAIGSGGNYALAAGRALKKHAGESMSASEIARAA LETAGEICVYTNDQIILEELE*" /label="clpQ CDS" gene 1561935..1562480 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /label="clpQ gene" CDS 1562497..1563900 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (ATPase andchaperone)" /protein_id="NP_389498.1" /db_xref="EnsemblGenomes-Gn:BSU16160" /db_xref="EnsemblGenomes-Tr:CAB13489" /db_xref="GOA:P39778" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004491" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10967" /db_xref="UniProtKB/Swiss-Prot:P39778" /translation="MEKKPLTPRQIVDRLDQYIVGQQNAKKAVAVALRNRYRRSLLDE KLKDEVVPKNILMMGPTGVGKTEIARRIAKLSGAPFIKIEATKFTEVGYVGRDVESMV RDLVETSVRLIKEEKMNEVKEQAEENANKRIVRLLVPGKKKQSGVKNPFEMFFGGSQP NGEDEAESQEEANIEEKRKRMAHQLALGELEDYYVTVEVEEQQPSMFDMLQGSGMEQM GMNMQDALSGLMPKKKKRRKMTVREARKVLTNEEASKLIDMDEVGQEAVQRAEESGII FIDEIDKIAKNGGASSSADVSREGVQRDILPIVEGSTVVTKYGSVKTDHVLFIAAGAF HMAKPSDLIPELQGRFPIRVELNKLTVDDFVRILVEPDNALLKQYQALLQTEGISLEF SDEAIHKIAEVAYHVNQDTDNIGARRLHTILERLLEDLSFEAPDVTMEKITITPQYVE EKLGTIAKNKDLSQFIL*" /label="clpY CDS" gene 1562497..1563900 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /label="clpY gene" CDS 1563940..1564719 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, GTP and BCAA-dependent" /protein_id="NP_389499.1" /db_xref="EnsemblGenomes-Gn:BSU16170" /db_xref="EnsemblGenomes-Tr:CAB13490" /db_xref="GOA:P39779" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR013198" /db_xref="InterPro:IPR014154" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2B0L" /db_xref="PDB:2B18" /db_xref="PDB:2GX5" /db_xref="PDB:2HGV" /db_xref="PDB:5LNH" /db_xref="PDB:5LOE" /db_xref="PDB:5LOJ" /db_xref="PDB:5LOO" /db_xref="SubtiList:BG10968" /db_xref="UniProtKB/Swiss-Prot:P39779" /translation="MALLQKTRIINSMLQAAAGKPVNFKEMAETLRDVIDSNIFVVSR RGKLLGYSINQQIENDRMKKMLEDRQFPEEYTKNLFNVPETSSNLDINSEYTAFPVEN RDLFQAGLTTIVPIIGGGERLGTLILSRLQDQFNDDDLILAEYGATVVGMEILREKAE EIEEEARSKAVVQMAISSLSYSELEAIEHIFEELDGNEGLLVASKIADRVGITRSVIV NALRKLESAGVIESRSLGMKGTYIKVLNNKFLIELENLKSH*" /label="codY CDS" gene 1563940..1564719 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /label="codY gene" downshifts 1564694 /Source="Nicolas_upshifts" /id="D893" /incds=0 /nref=6 /ntot=130 /MaxReadThrough="5.35492" /MaxDrop="5.90286" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1564738 /Source="Nicolas_upshifts" /id="D894" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="4.95658" /MaxDrop="4.85551" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1564839..1564846 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1564859..1564877 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1564870..1565023 /Source="Nicolas_S_feature" /locus_tag="new_1691049_1691202" /HighExp="C30, GM 90, GM 25, Cold, GM 15, GM 10, MG 150, GM-0.2, LBGstat, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 0.994, 0.998" /TUlongSig="SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.999, 1, 1, 1" /label="S584" upshifts 1564870 /Source="Nicolas_upshifts" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1564998..1565005 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1565020..1565039 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1565025 /Source="Nicolas_upshifts" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1565099..1565488 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996, 17850253, 25843804; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389500.1" /db_xref="EnsemblGenomes-Gn:BSU16180" /db_xref="EnsemblGenomes-Tr:CAB13491" /db_xref="GOA:P24500" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006300" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10237" /db_xref="UniProtKB/Swiss-Prot:P24500" /translation="MSLFSGTIQNLENALSRADIKQKVITNNIANIDTPNYKAKKVSF QNLLDQESSRLEAIKTDYRHVDFSDTDSNYSIVASGDTSYQQNGNNVDVDKEMTELAQ NQINYQALVERMNGKFNSLKTVLTGGK*" /label="flgB CDS" gene 1565099..1565488 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /label="flgB gene" CDS 1565488..1565940 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389501.1" /db_xref="EnsemblGenomes-Gn:BSU16190" /db_xref="EnsemblGenomes-Tr:CAB13492" /db_xref="GOA:P24501" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006299" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10238" /db_xref="UniProtKB/Swiss-Prot:P24501" /translation="MTAFHSLNVSASALTAQRVRMDVVSSNLANMDTTRAKQVNGEWV PYRRKMVSLQSKGESFSSILNSQMSGSGNAGNGVKVSKITEDDSDFNLVYDPTDPDAN AEGYVQKPNVDPLKEMVDLVSSTRSYEANVTAMNATKGMLMKALEIGK*" /label="flgC CDS" gene 1565488..1565940 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /label="flgC gene" CDS 1565951..1566271 /gene="fliE" /locus_tag="BSU_16200" /old_locus_tag="BSU16200" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133968, 1551848, 1905667, 2544561, 9161424, 11133968, 15136044; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal body protein" /protein_id="NP_389502.1" /db_xref="EnsemblGenomes-Gn:BSU16200" /db_xref="EnsemblGenomes-Tr:CAB13493" /db_xref="GOA:P24502" /db_xref="InterPro:IPR001624" /db_xref="SubtiList:BG10239" /db_xref="UniProtKB/Swiss-Prot:P24502" /translation="MINAISPFQVQNTQNTQNATNQVNNSQKTDSSNQTSFSELLKNS ISSLNESQVASDNMTNALAAGKDVNLDEVMIAAQKASISLTAATEFRNKAVEAYQEIM RMQM*" /label="fliE CDS" gene 1565951..1566271 /gene="fliE" /locus_tag="BSU_16200" /old_locus_tag="BSU16200" /label="fliE gene" downshifts complement(1566266) /Source="Nicolas_upshifts" /id="D895" /incds=0 /nref=1 /ntot=83 /MaxReadThrough="1.38909" /MaxDrop="2.66249" /score="0.0645368779" /energy="-7.4" /TU="NA" /idTUdmin="U1325" /TUdmin=2684 /isTUend="FALSE" /label="downshifts" CDS 1566317..1567927 /gene="fliF" /locus_tag="BSU_16210" /old_locus_tag="BSU16210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1551848, 1905667, 2544561, 9161424, 11133968, 22670715, 24970213, 28089452; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body M-ring protein" /protein_id="NP_389503.1" /db_xref="EnsemblGenomes-Gn:BSU16210" /db_xref="EnsemblGenomes-Tr:CAB13494" /db_xref="GOA:P23447" /db_xref="InterPro:IPR000067" /db_xref="InterPro:IPR006182" /db_xref="InterPro:IPR013556" /db_xref="InterPro:IPR021157" /db_xref="SubtiList:BG10240" /db_xref="UniProtKB/Swiss-Prot:P23447" /translation="MNRTLMQMKNKTSEFWKNRSKLQKILMVSALAAIIIIGIIISVF ASNSKMAPLYKDLSAEEAGQIKEELDAKKVPNELSNGGTVISVPEDQVDSLKVQMAAE GLPKTGSIDYSFFGQNAGFGLTDNEFDMVKVKATQTELSNLINEMDGIKNSKVMINLP KDAVFVGEEQSAASASIVLQIQPGYTLDQSQINGLYHLVSKSVPNLKEDNIVIMDQNS TYYDKSDSDAGSYADSYSSQQGIKSQVEKDIQKHVQSLLGTMMGQDKVVVSVTADIDF TKENRTEDIVEPVDKENMEGIAVSAEKVSETYQGDGAANGGTAGTGEEDVTNYKADGE NTESGNYEKNSNKINYEVNRIHKEIAESPYKVRDLGIQVMVEPPDAKNTASLSTERQD DIQKILSTVVRTSLDKDETQNQNLSDADINNKIVVSVQPFDGKVNLDTNTEESSGIPL WAYIVGGVLIAAIIVLIIMLIRKKRAQEDEFEEYEYEVPQEPINLPDINEEENETAES VRRKQLEKMAKDKPEDFAKLLRSWLAED*" /label="fliF CDS" gene 1566317..1567927 /gene="fliF" /locus_tag="BSU_16210" /old_locus_tag="BSU16210" /label="fliF gene" CDS 1567940..1568956 /gene="fliG" /locus_tag="BSU_16220" /old_locus_tag="BSU16220" /function="16.5: Explore" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1551848, 1905667, 2544561, 9161424, 10440379, 11133968, 28089452; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing component" /protein_id="NP_389504.1" /db_xref="EnsemblGenomes-Gn:BSU16220" /db_xref="EnsemblGenomes-Tr:CAB13495" /db_xref="GOA:P23448" /db_xref="InterPro:IPR000090" /db_xref="InterPro:IPR011002" /db_xref="InterPro:IPR023087" /db_xref="InterPro:IPR028263" /db_xref="InterPro:IPR032779" /db_xref="SubtiList:BG10241" /db_xref="UniProtKB/Swiss-Prot:P23448" /translation="MARRDQDKLTGKQKAAILMISLGLDVSASVYKHLTDEEIERLTL EISGVRSVDHQKKDEIIEEFHNIAIAQDYISQGGLSYARQVLEKALGEDKAENILNRL TSSLQVKPFDFARKAEPEQILNFIQQEHPQTMALILSYLDPVQAGQILSELNPEVQAE VARRIAVMDRTSPEIINEVERILEQKLSSAFTQDYTQTGGIEAVVEVLNGVDRGTEKT ILDSLEIQDPDLAEEIKKRMFVFEDIVTLDNRAIQRVIRDVENDDLLLSLKVASEEVK EIVFNNMSQRMVETFKEEMEFMGPVRLKDVEEAQSRIVSIVRKLEEAGEIVIARGGGD DIIV*" /label="fliG CDS" gene 1567940..1568956 /gene="fliG" /locus_tag="BSU_16220" /old_locus_tag="BSU16220" /label="fliG gene" S_feature 1568957..1569074 /Source="Nicolas_S_feature" /locus_tag="new_1695136_1695253" /HighExp="Lbstat, C90, M0t90, M40t90, Lbtran, C30, LPhT, GM 90, M40t45, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.998, 1, 0.998" /TUlongSig="SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.994, 1, 0.999, 1, 1, 1" /label="S585" promotor_no_box complement(1569020..1569120) /Source="Nicolas_upshift_promotors" /id="U1325" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.937062937062937" /psig="0.00999000999001" /xcortree=81 /SigmaFactorBS="ttgcctgctcagaaatccggtcagcttcctctttcactcggg ccataagcgcctccgggttctcttcagcctgcaaaaggtgagaatgatcaatacgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1569060) /Source="Nicolas_upshifts" /id="U1325" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.937062937062937" /psig="0.00999000999001" /xcortree=81 /SigmaFactorBS="ttgcctgctcagaaatccggtcagcttcctctttcactcggg ccataagcgcctccgggttctcttcagcctgcaaaaggtgagaatgatcaatacgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1569075..1569701 /gene="fliH" /locus_tag="BSU_16230" /old_locus_tag="BSU16230" /function="16.6: Maintain" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1828465, 12217691, 16522800, 17002279, 26916245; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar export apparatus subunit of cytoplasmic ATPase" /protein_id="NP_389505.2" /db_xref="EnsemblGenomes-Gn:BSU16230" /db_xref="EnsemblGenomes-Tr:CAB13496" /db_xref="GOA:P23449" /db_xref="InterPro:IPR018035" /db_xref="InterPro:IPR022524" /db_xref="SubtiList:BG10242" /db_xref="UniProtKB/Swiss-Prot:P23449" /translation="MARVKEEADRISEQANSHIENIRRQIEQEKNDWAAEKQKLIEEA KAEGFEQGVALGKAEAMKQYAELIGQANSITEMSRKAVEDKLEDANEEIVELAVALAK KVWQQKSDDKEAFLLLVQQVINEVKEYDDISIYVDPYYYETIFQQKDEIQQLLYKECR LGIYADEKAQKGTCYIETPFGRVDASVDTQLMQLKDKLLTALEAGAAE*" /label="fliH CDS" gene 1569075..1569701 /gene="fliH" /locus_tag="BSU_16230" /old_locus_tag="BSU16230" /label="fliH gene" CDS 1569698..1571014 /gene="fliI" /locus_tag="BSU_16240" /old_locus_tag="BSU16240" /EC_number="3.6.3.14" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787361, 16113269, 16780875, 17002279, 26916245; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="flagellar-specific ATPase subunit of export apparatus" /protein_id="NP_389506.2" /db_xref="EnsemblGenomes-Gn:BSU16240" /db_xref="EnsemblGenomes-Tr:CAB13497" /db_xref="GOA:P23445" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000225" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005714" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR022425" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032463" /db_xref="SubtiList:BG10243" /db_xref="UniProtKB/Swiss-Prot:P23445" /translation="MKTQSLIDCIEMTDSYKRYGKVKRVIGLMIESKGPASSIGDLCL IYAKGQSGKVIKAEVVGFQEENILLMPYLEAASIAPGSIVEATGESLRVKVGTGLIGQ VIDAFGEPLDGKLLPKGLSPVSTEQSPPNPMKRPPIREKMGVGVRSIDSLLTVGKGQR IGIFAGSGVGKSTLMGMIAKQTEADLNVIALVGERGREVREFIEKDLGKEGLKRSIVV VATSDQPALMRLKAAYTATAIAEYFRDKGQNVMFMMDSVTRVAMAQREIGLAAGEPPT TKGYTPSVFAILPRLLERTGANEHGTITAFYTVLVDGDDMNEPIADTVRGILDGHIVL DRALANKGQFPAVNVLKSISRVMSNISTKQHLDAANKFRELLSTYQNSEDLINIGAYK RGSSREIDEAIQFYPQLIQFLKQGTDEPALLEESIAALTSLTGNEE*" /label="fliI CDS" gene 1569698..1571014 /gene="fliI" /locus_tag="BSU_16240" /old_locus_tag="BSU16240" /label="fliI gene" CDS 1571017..1571460 /gene="fliJ" /locus_tag="BSU_16250" /old_locus_tag="BSU16250" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17088562, 26916245, 26984495, 27647891; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar synthesis rod subunit of export ATPase" /protein_id="NP_389507.1" /db_xref="EnsemblGenomes-Gn:BSU16250" /db_xref="EnsemblGenomes-Tr:CAB13498" /db_xref="GOA:P20487" /db_xref="InterPro:IPR012823" /db_xref="SubtiList:BG10245" /db_xref="UniProtKB/Swiss-Prot:P20487" /translation="MAYQFRFQKLLELKENEKDQSLSEYQQSVSEFENVAEKLYENMS KKELLEQNKEKKLKSGMSVQEMRHYQQFVSNLDNTIYHYQKLVIMKRNQMNQKQEILT EKNIEVKKFEKMREKQFKMFALEDKAAEMKEMDDISIKQFMIQGH*" /label="fliJ CDS" gene 1571017..1571460 /gene="fliJ" /locus_tag="BSU_16250" /old_locus_tag="BSU16250" /label="fliJ gene" CDS 1571472..1572086 /gene="ylxF" /locus_tag="BSU_16260" /old_locus_tag="BSU16260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17586671, 22307758; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative kinesin-like protein" /protein_id="NP_389508.2" /db_xref="EnsemblGenomes-Gn:BSU16260" /db_xref="EnsemblGenomes-Tr:CAB13499" /db_xref="GOA:P23454" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR011002" /db_xref="SubtiList:BG10246" /db_xref="UniProtKB/Swiss-Prot:P23454" /translation="MSGKKKESGKFRSVLLIIILPLMFLLIAGGIVLWAAGINVLKPI QDAAAKTPVLKELVPETENKKGAASSKDSSNTAALEKTIKDQKSEISILNKDLETSKS EIDRLNQKIRSLEKTAEDQKKSSEDHTEGSADSKASSENDKVISVYKSMDSGKAAKII AQLKEQEALKILNGLSKKQLADILAKMTPEQAATYTEKIAASQE*" /label="ylxF CDS" gene 1571472..1572086 /gene="ylxF" /locus_tag="BSU_16260" /old_locus_tag="BSU16260" /label="ylxF gene" CDS 1572099..1573562 /gene="fliK" /locus_tag="BSU_16270" /old_locus_tag="BSU16270" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16630628, 16949608, 28557186; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook-length control protein (ruler)" /protein_id="NP_389509.2" /db_xref="EnsemblGenomes-Gn:BSU16270" /db_xref="EnsemblGenomes-Tr:CAB13500" /db_xref="GOA:P23451" /db_xref="InterPro:IPR001635" /db_xref="InterPro:IPR021136" /db_xref="SubtiList:BG10247" /db_xref="UniProtKB/Swiss-Prot:P23451" /translation="MKLLELAGPLLQTTTGSAAKNMKSSQGVFQNWLMSEAGLKELSE QGKGTPNSEDQLLADALKKIGEWLNASPEDQDKQNADLLQTLSKLTGKQLDANALQML QNLLQAVESKMSGGTDQLLTETEKIFSEAKTALSANDSASDINGALKSDKEQSNQENE VSEPAKELIYIQMFISQLVEGNKLTDLGNGNEAHAIYQNGDQFLSALEKKGVSQQLIQ DLKQQIFTKAESSSKLYSMTASELKSFQSLMDQMSMLPQKGTKEWSLAESQLKAFLLS KSSESSQDFGKSVLTPLSQSSSSKNASDVSGSIQPVDSKSGLQMLFSGYRGIGGVQTL DLQQMSSDIPNAETKTVADQVINAWKQMKYTPFGRSTGSFTIRLNPEHLGFVTIKLTN ENGMFQSKIIASSQSAKELLEQHLPQLKQSLPNMAVQIDRFTLPVQSGDQPIYGQLAD EQKQQQEGQRQQRQKKQSNDFGDLLDEVSMVEMEEEE*" /label="fliK CDS" gene 1572099..1573562 /gene="fliK" /locus_tag="BSU_16270" /old_locus_tag="BSU16270" /label="fliK gene" CDS 1573559..1573981 /gene="flgD" /locus_tag="BSU_16280" /old_locus_tag="BSU16280" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8157595, 14563871, 24748615; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook capping protein" /protein_id="NP_389510.1" /db_xref="EnsemblGenomes-Gn:BSU16280" /db_xref="EnsemblGenomes-Tr:CAB13501" /db_xref="GOA:P23455" /db_xref="InterPro:IPR005648" /db_xref="SubtiList:BG10248" /db_xref="UniProtKB/Swiss-Prot:P23455" /translation="MTSISSEYKLPEKTNTVSTNNSSLGKDEFLKILMTQVQNQDPLN PIDDKEFISQMATFSSLEQMMNLNTTMTQFVENQDPFTTYVDWMGKEVSWTDGKSATD KTGTVSSVKHFKGNYYLVLDDGTEISPANVMSVGQSSK*" /label="flgD CDS" gene 1573559..1573981 /gene="flgD" /locus_tag="BSU_16280" /old_locus_tag="BSU16280" /label="flgD gene" CDS 1574003..1574797 /gene="flgE" /locus_tag="BSU_16290" /old_locus_tag="BSU16290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15502333, 15510139, 27759043, 28120828, 28429800; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook protein" /protein_id="NP_389511.2" /db_xref="EnsemblGenomes-Gn:BSU16290" /db_xref="EnsemblGenomes-Tr:CAB13502" /db_xref="GOA:P23446" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR012836" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10249" /db_xref="UniProtKB/Swiss-Prot:P23446" /translation="MLRSLYSGISGMKNFQTKLDVIGNNIANVNTVGFKKSRVTFKDM VSQTIAGGSAAGATIGGTNSKQIGLGSSSGTIDTIHSTSATQSTGRTLDLAIDGDGYF RIDTGDGTAYTRAGNFYLDNTGTLVTGDGYHVLNMNGGTIKIPTDAQSFSIGSDGKVS IVDAEGKTQDGGQIGIVTFANSDGLDKIGSNLYRESLNSGTASAANQPGDGGTGALKS GFLEMSNVDLTDEFTEMIVAQRGFQSNSKIITTSDEILQELVNLKR*" /label="flgE CDS" gene 1574003..1574797 /gene="flgE" /locus_tag="BSU_16290" /old_locus_tag="BSU16290" /label="flgE gene" CDS 1574837..1575052 /gene="swrD" /locus_tag="BSU_16299" /old_locus_tag="BSU16299" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9168127, 29061663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9168127, 29061663; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar power transducer required for swarming" /protein_id="YP_003097728.1" /db_xref="EnsemblGenomes-Gn:BSU16299" /db_xref="EnsemblGenomes-Tr:CAX52619" /db_xref="InterPro:IPR009384" /db_xref="UniProtKB/Swiss-Prot:C0H412" /translation="MIKVTRLNGQPFTLNALFIEQIECFPDTTITLSNGKKFVVKEDE EAVLEKIAAFYRKIQIFAMDQGIEEPE*" /label="swrD CDS" gene 1574837..1575052 /gene="swrD" /locus_tag="BSU_16299" /old_locus_tag="BSU16299" /label="swrD gene" CDS 1575049..1575471 /gene="fliL" /locus_tag="BSU_16300" /old_locus_tag="BSU16300" /function="16.5: Explore" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10439416, 12787361, 16166542, 23264580, 25714720, 28717192; Product type f : factor" /codon_start=1 /transl_table=11 /product="flagellar basal-body (stator) associated protein" /protein_id="NP_389512.1" /db_xref="EnsemblGenomes-Gn:BSU16300" /db_xref="EnsemblGenomes-Tr:CAB13503" /db_xref="GOA:P23452" /db_xref="InterPro:IPR005503" /db_xref="SubtiList:BG10250" /db_xref="UniProtKB/Swiss-Prot:P23452" /translation="MKKKLMIILLIILIVIGALGAAAYFVLGGKSEKSEAKKSIDEIV ASSVDVEEITTNLKSDNIIRLAIKLETDSDKSKEELEKRDFQVKDAVISLLADTNADQ IEGDKGKETFKKELKDKINSYLQEGKVEKVYITSFNLQ*" /label="fliL CDS" gene 1575049..1575471 /gene="fliL" /locus_tag="BSU_16300" /old_locus_tag="BSU16300" /label="fliL gene" CDS 1575505..1576503 /gene="fliM" /locus_tag="BSU_16310" /old_locus_tag="BSU16310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7787061, 16547037, 16796690, 16882724, 17015643, 17050923, 22720735, 28625846; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing component" /protein_id="NP_389513.1" /db_xref="EnsemblGenomes-Gn:BSU16310" /db_xref="EnsemblGenomes-Tr:CAB13504" /db_xref="GOA:P23453" /db_xref="InterPro:IPR001543" /db_xref="InterPro:IPR001689" /db_xref="InterPro:IPR028976" /db_xref="InterPro:IPR036429" /db_xref="SubtiList:BG10251" /db_xref="UniProtKB/Swiss-Prot:P23453" /translation="MSGEVLSQNEIDALLSAISTGEMDAEELKKEEKEKKVKVYDFKR ALRFSKDQIRSLTRIHDNFARLLTTHFSAQLRTYIHISVSSVDQVPYEEFIRSIPNMT ILNLFDVHPMEGRIMMEVNPTIAYTMMDRVMGGIGISHNKVDSLTEIETKIISNLFEN ALGNYKEAWQSIADIEPEMTEFEVNPQFVQMVSPNETVVVISLNTQIGEISGVINLCI PHIVLEPLIPKLSVHYWMQSDRNEPKPEETKSLEKRIMTAQIPVVAELGTSELTIEEF LSLEVGDCITLDKSVTDPLTVLVGDKPKFLGQAGRVNRKQAVQILDHDIRGEQDGE*" /label="fliM CDS" gene 1575505..1576503 /gene="fliM" /locus_tag="BSU_16310" /old_locus_tag="BSU16310" /label="fliM gene" CDS 1576493..1577629 /gene="fliY" /locus_tag="BSU_16320" /old_locus_tag="BSU16320" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12920116, 16547037, 16796690, 16882724, 17015643, 17050923, 23226535, 23532838, 26195616" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12920116, 16547037, 16796690, 16882724, 17015643, 17050923, 23226535, 23532838, 26195616; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing phosphatase" /protein_id="NP_389514.1" /db_xref="EnsemblGenomes-Gn:BSU16320" /db_xref="EnsemblGenomes-Tr:CAB13505" /db_xref="GOA:P24073" /db_xref="InterPro:IPR001172" /db_xref="InterPro:IPR001543" /db_xref="InterPro:IPR007597" /db_xref="InterPro:IPR012826" /db_xref="InterPro:IPR028976" /db_xref="InterPro:IPR036429" /db_xref="SubtiList:BG10252" /db_xref="UniProtKB/Swiss-Prot:P24073" /translation="MENNRLSQDEIDALLNGTGSTLDEPEIPEVDDLSEMERDAIGEI GNISFGSSATALSTLLNQKVDITTPSVTVIPRSKISDAFPEPYVAIEVNYTEGFSGSN LLVVEQSDAAIIADLMIGGDGKGADPSLGEIHLSAVQEAMNQMMGSAATSMSTVFSKK IDISPPRVELLDVTEEKGTDRIPDDEMLVKVSFNLKVGELIDSSIMQLYPLTFAKDLI SSLMNSESAEEEETVQPEVTYEQPKEPVTPEPRIEPKQQQQPPKRQGTAKKAAPVQVS PVEFSAFDPNEAVQAPIHNLDMLLDIPLSITVELGRTKRSVKEILELSAGSIIELDKL AGEPVDILVNQRIVAKGEVVVIEENFGVRVTDILSQAERINNLK*" /label="fliY CDS" gene 1576493..1577629 /gene="fliY" /locus_tag="BSU_16320" /old_locus_tag="BSU16320" /label="fliY gene" CDS 1577655..1578017 /gene="cheY" /locus_tag="BSU_16330" /old_locus_tag="BSU16330" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10196193, 12864845, 12920116, 14749334, 23226535, 28542702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10196193, 12864845, 12920116, 14749334, 23226535, 28542702; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of chemotaxis and motility" /protein_id="NP_389515.1" /db_xref="EnsemblGenomes-Gn:BSU16330" /db_xref="EnsemblGenomes-Tr:CAB13506" /db_xref="GOA:P24072" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG10258" /db_xref="UniProtKB/Swiss-Prot:P24072" /translation="MAHRILIVDDAAFMRMMIKDILVKNGFEVVAEAENGAQAVEKYK EHSPDLVTMDITMPEMDGITALKEIKQIDAQARIIMCSAMGQQSMVIDAIQAGAKDFI VKPFQADRVLEAINKTLN*" /label="cheY CDS" gene 1577655..1578017 /gene="cheY" /locus_tag="BSU_16330" /old_locus_tag="BSU16330" /label="cheY gene" CDS 1578032..1578691 /gene="fliZ" /locus_tag="BSU_16340" /old_locus_tag="BSU16340" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10791024, 1597417, 16513753, 24204316; Product type r: regulator" /codon_start=1 /transl_table=11 /product="flagellar regulatory protein" /protein_id="NP_389516.1" /db_xref="EnsemblGenomes-Gn:BSU16340" /db_xref="EnsemblGenomes-Tr:CAB13507" /db_xref="GOA:P35536" /db_xref="InterPro:IPR022781" /db_xref="SubtiList:BG10259" /db_xref="UniProtKB/Swiss-Prot:P35536" /translation="MKKSQYFIVFICFFVLFSVHPIAAAAADSDNSTVNEWFQKKDEK TADQSEQKKEKTTKTADETEGAAAPSVSAFDFVKMIFALLFVIVLIYGLVKLMNKRNR LLKPFQYVENIGGTSVGQNRSIQLIKVGKSVLVVGVGETIQLLKEIEDEKEIEVILSQ HEEAMSSKIEWQKFVKPLKSSEHQPQQKLPSFSKALKEQLEELKQNRSEGKKKGPRHH E*" /label="fliZ CDS" gene 1578032..1578691 /gene="fliZ" /locus_tag="BSU_16340" /old_locus_tag="BSU16340" /label="fliZ gene" CDS 1578684..1579349 /gene="fliP" /locus_tag="BSU_16350" /old_locus_tag="BSU16350" /function="16.3: Control" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15516571, 15849754, 16850406, 22720735, 26244495, 27855178, 28559296; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389517.1" /db_xref="EnsemblGenomes-Gn:BSU16350" /db_xref="EnsemblGenomes-Tr:CAB13508" /db_xref="GOA:P35528" /db_xref="InterPro:IPR005837" /db_xref="InterPro:IPR005838" /db_xref="SubtiList:BG10260" /db_xref="UniProtKB/Swiss-Prot:P35528" /translation="MNEFINIFSSSDPENVSSTVKLLLLLTVFSVAPGILILMTCFTR IVIVLSFVRTSLATQSMPPNQVLIGLALFLTFFIMAPTFSEINKEALTPLMDNKISLD EAYTKAEEPIKEFMSKHTRQKDLALFMNYAKMDKPESLKDIPLTTMVPAFAISELKTA FQIGFMIFIPFLIIDMVVASVLMSMGMMMLPPVMISLPFKILLFVLVDGWYLIVKSLL QSF*" /label="fliP CDS" gene 1578684..1579349 /gene="fliP" /locus_tag="BSU_16350" /old_locus_tag="BSU16350" /label="fliP gene" CDS 1579364..1579633 /gene="fliQ" /locus_tag="BSU_16360" /old_locus_tag="BSU16360" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10234819, 15516571, 27855178; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389518.1" /db_xref="EnsemblGenomes-Gn:BSU16360" /db_xref="EnsemblGenomes-Tr:CAB13509" /db_xref="GOA:P35535" /db_xref="InterPro:IPR002191" /db_xref="InterPro:IPR006305" /db_xref="SubtiList:BG10261" /db_xref="UniProtKB/Swiss-Prot:P35535" /translation="MSSEFVISMAEKAVYVTLMISGPLLAIALLVGLIVSIFQATTQI QEQTLAFIPKIVAVLLALIFFGPWMLSTILSFTTELFSNLNRFAG*" /label="fliQ CDS" gene 1579364..1579633 /gene="fliQ" /locus_tag="BSU_16360" /old_locus_tag="BSU16360" /label="fliQ gene" CDS 1579641..1580420 /gene="fliR" /locus_tag="BSU_16370" /old_locus_tag="BSU16370" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060055, 15516571, 15849754, 16850406, 28771474; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389519.2" /db_xref="EnsemblGenomes-Gn:BSU16370" /db_xref="EnsemblGenomes-Tr:CAB13510" /db_xref="GOA:P35537" /db_xref="InterPro:IPR002010" /db_xref="InterPro:IPR006303" /db_xref="SubtiList:BG10262" /db_xref="UniProtKB/Swiss-Prot:P35537" /translation="MNSIIDLFPAFLLVFIRISAFFVTIPLFGHRNVPAVHRIGFAFF LAVICFSTIDKPPSLEIDEHYMLLAFKEALVGLCLGLIAYMMIAAVQIAGSFIDFQMG FSIANVIDPQTGAQSPLIGQFIYTMALLFMLSVNAHHLLLDGIYYSFQYISVDQAFPN FGDEKFAYFIAKSFNAMFIIAFQMSAPVVASLFLVDLALGIVARTVPQLNVFVVGLPL KIAVSFIMLIVCMSVIFVVVRNVFSLTIETMRNLLALVGVS*" /label="fliR CDS" gene 1579641..1580420 /gene="fliR" /locus_tag="BSU_16370" /old_locus_tag="BSU16370" /label="fliR gene" CDS 1580420..1581502 /gene="flhB" /locus_tag="BSU_16380" /old_locus_tag="BSU16380" /function="16.1: Circulate" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10234819, 16949608, 17050924, 17067800, 28557186, 28771466; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389520.1" /db_xref="EnsemblGenomes-Gn:BSU16380" /db_xref="EnsemblGenomes-Tr:CAB13511" /db_xref="GOA:P35538" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR006136" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG10543" /db_xref="UniProtKB/Swiss-Prot:P35538" /translation="MKLRVDLQFFAGEKTEKATPKKRKDTRKKGQVAKSSDVNTAVSL LVIFLSLIAIGPYMRDRLLSFIETFYTESLTMKLSESNVHTLFVSLLKDMGMILAPIL LVALVAGVVSNYMQVGFLFSAEVIQPKLEKLDPIKGFKRIYSMRAIVELIKSILKIVV VGFAAFAVLWLHYGEILRLPLLTPEEALSFVSKLTLWMGLSGAGALLILAGLDYLYQR FDYEKNIKMSKQDIKDEYKKSEGDPIIKSKIKQRQREMAMRRMMQEVPKADVIITNPT HYAIALKYDEEKMDAPYIVAKGVDHLALKIRKIAKEHDVMMVENRPLARALYDQVEID QAVPEEFFKVLAEILAYVYKTKQKVY*" /label="flhB CDS" gene 1580420..1581502 /gene="flhB" /locus_tag="BSU_16380" /old_locus_tag="BSU16380" /label="flhB gene" CDS 1581535..1583568 /gene="flhA" /locus_tag="BSU_16390" /old_locus_tag="BSU16390" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10234819, 15516571, 20534509, 28771466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10234819, 15516571, 20534509, 28771466; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389521.2" /db_xref="EnsemblGenomes-Gn:BSU16390" /db_xref="EnsemblGenomes-Tr:CAB13512" /db_xref="GOA:P35620" /db_xref="InterPro:IPR001712" /db_xref="InterPro:IPR006301" /db_xref="InterPro:IPR025505" /db_xref="PDB:3MIX" /db_xref="SubtiList:BG10542" /db_xref="UniProtKB/Swiss-Prot:P35620" /translation="MSTRDLSVLISVVLIVAMLVIPFPPWLLSILIIINISLALIVLL TTMNMQEALQFSIFPSLLLLLTLFRLGLNVSTTRSILSHGEGGKVVETFGNFVVGGNV LVGLVVFIILIIIQFIVITKGAERVSEVAARFTLDAMPGKQMSIDADLNAGMITEQEA KHRREKVAREADFYGAMDGASKFVKGDAIAGIIIVMINIIFGIVIGMLQQGMSIQEAA SHFTMLTVGDGIVSQIPALLISTATGIVVTRAASEGNLGHDITGQLFAYPKLLYVAAA TIMLLGIFTPIGILLTGPLAGLLAFGAYTLSKSGKEKEEVDEILEEEAEVDELKSPES VVQLLHIDPIEFEFGYGLIPLADANQGGDLLDRIVMIRRQLALELGLVIPVVRIRDNI ALQPNEYRLKIKGNEVAKGELLLDHYLAMSPTPEDDLIEGIETVEPSFGLPAKWISEA VKDEADMLGYTVVDPASVVSTHITEKIKQHAHELIGRQETKQLIDHLKESYPVLVEEV TPNPLSVGDIQKVLAKLLKEKVSIRNLVTIFETLADYGKLTTDSDLLTEYTRQALAKQ ITAQFAKENEVLKVVTCSGRVEKAIADGVQQTEHGNYLSLEPDISESIVRSVAKEAEQ LSLRQETAILLCSPPVRMYVKQLLERYFPDLPVLSYNELEANVEVQSIGVVDI*" /label="flhA CDS" gene 1581535..1583568 /gene="flhA" /locus_tag="BSU_16390" /old_locus_tag="BSU16390" /label="flhA gene" CDS 1583568..1584668 /gene="flhF" /locus_tag="BSU_16400" /old_locus_tag="BSU16400" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1447978, 15317803, 16980502, 17565194, 17699634, 26195616, 27807433; Product type t: transporter" /codon_start=1 /transl_table=11 /product="GTPase involved in the export of flagella and number regulation" /protein_id="NP_389522.1" /db_xref="EnsemblGenomes-Gn:BSU16400" /db_xref="EnsemblGenomes-Tr:CAB13513" /db_xref="GOA:Q01960" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR020006" /db_xref="InterPro:IPR027417" /db_xref="PDB:2PX0" /db_xref="PDB:2PX3" /db_xref="PDB:3SYN" /db_xref="SubtiList:BG10544" /db_xref="UniProtKB/Swiss-Prot:Q01960" /translation="MKIKKFTAASMQEAALLIRKELGNEAVILNSKKIKKRKWFGLVN KPAVEVIAVLDQDFLEKKTPQKAAEPKQTLKTPVSSPKIEERTYPPQIPAQQELGDFS AYQSVLPEPLRKAEKLLQETGIKESTKTNTLKKLLRFSVEAGGLTEENVVGKLQEILC DMLPSADKWQEPIHSKYIVLFGSTGAGKTTTLAKLAAISMLEKHKKIAFITTDTYRIA AVEQLKTYAELLQAPLEVCYTKEEFQQAKELFSEYDHVFVDTAGRNFKDPQYIDELKE TIPFESSIQSFLVLSATAKYEDMKHIVKRFSSVPVNQYIFTKIDETTSLGSVFNILAE SKIGVGFMTNGQNVPEDIQTVSPLGFVRMLCR*" /label="flhF CDS" gene 1583568..1584668 /gene="flhF" /locus_tag="BSU_16400" /old_locus_tag="BSU16400" /label="flhF gene" promotor_-10 complement(1584545..1584564) /Source="Nicolas_upshift_promotors" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1584552) /Source="Nicolas_upshifts" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1584578..1584587) /Source="Nicolas_upshift_promotors" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1584659..1585555 /gene="flhG" /locus_tag="BSU_16410" /old_locus_tag="BSU16410" /function="16.5: Explore" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15361076, 25733861, 26411371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15361076, 25733861, 26411371; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase affecting flagellar basal body localisation and number" /protein_id="NP_389523.1" /db_xref="EnsemblGenomes-Gn:BSU16410" /db_xref="EnsemblGenomes-Tr:CAB13514" /db_xref="GOA:P40742" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR033875" /db_xref="PDB:3SYN" /db_xref="SubtiList:BG10254" /db_xref="UniProtKB/Swiss-Prot:P40742" /translation="MQMNRYDQAATLRAKMEKRERVLPMVYSQKAKTLAVISGKGGVG KSNITLNMALALQDKGKKVLLIDLDIGMGNIDILIGNSSSATIIDVLTDRKPLLQSLS VGPKGLRYISGGTGLDVMFQLDQRKWTFFANELSHALSQFDYVLFDMGAGLSKDQLPF ILSAEDILIITTPEPTAIMDAYSAVKHLVLTENKLSMKVAVNRCRDQKEGLDAFARLS RTIHMFLDVQVQFAGSVSDDVIVSKAVVEQVPFFIKSPQAKASRSVRILADALFEREE TRHKEDKQTFIEKLSSFLMRRA*" /label="flhG CDS" gene 1584659..1585555 /gene="flhG" /locus_tag="BSU_16410" /old_locus_tag="BSU16410" /label="flhG gene" CDS 1585557..1586630 /gene="cheB" /locus_tag="BSU_16420" /old_locus_tag="BSU16420" /EC_number="3.1.1.61" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1738311, 10632876, 12123464, 21515776" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1738311, 10632876, 12123464, 21515776; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCP)-glutamate methylesterase" /protein_id="NP_389524.2" /db_xref="EnsemblGenomes-Gn:BSU16420" /db_xref="EnsemblGenomes-Tr:CAB13515" /db_xref="GOA:Q05522" /db_xref="InterPro:IPR000673" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR008248" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR035909" /db_xref="SubtiList:BG10255" /db_xref="UniProtKB/Swiss-Prot:Q05522" /translation="MIRVLVVDDSAFMRKMISDFLTEEKQIEVIGTARNGEEALKKIE LLKPDVITLDVEMPVMNGTDTLRKIIEIYNLPVIMVSSQTEKGKECTINCLEIGAFDF ITKPSGSISLDLYKIKEQLVERVVAAGLSGKRKRPVSQTVRPEPIVRAVVKPELSKPK PGTGRQIVCIGTSTGGPRALQKVIPKLPKDLNAPVVVVQHMPEGFTASLADRLNHLSD IQVKEAKDGEAALNGCVYIAPGGKNISVIKNSEGLQVVLDNHDTPSRHKPSADYLFRS VGKLTDYEKVAVIMTGMGSDGTAGLKDMLTAGNVKAIAESEESCVVYGMPKAAVKAGL IHEIKHVEDIAASITSCVKKERV*" /label="cheB CDS" gene 1585557..1586630 /gene="cheB" /locus_tag="BSU_16420" /old_locus_tag="BSU16420" /label="cheB gene" CDS 1586636..1588654 /gene="cheA" /locus_tag="BSU_16430" /old_locus_tag="BSU16430" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12094812, 12864845, 12920116, 15451661, 16045621, 21515776, 22355139" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12094812, 12864845, 12920116, 15451661, 16045621, 21515776, 22355139; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotactic two-component sensor histidine kinase" /protein_id="NP_389525.2" /db_xref="EnsemblGenomes-Gn:BSU16430" /db_xref="EnsemblGenomes-Tr:CAB13516" /db_xref="GOA:P29072" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004105" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008207" /db_xref="InterPro:IPR010808" /db_xref="InterPro:IPR035891" /db_xref="InterPro:IPR036061" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036641" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037006" /db_xref="InterPro:IPR037052" /db_xref="SubtiList:BG10256" /db_xref="UniProtKB/Swiss-Prot:P29072" /translation="MDMNQYLDVFIDESKEHLQTCNEKLLLLEKDPTDLQLVHDIFRA AHTLKGMSATMGYTDLAHLTHLLENVLDAIRNGDMEVTSDWLDILFEALDHLETMVQS IIDGGDGKRDISEVSAKLDVNGAHAESAASAEPAEAQSSASDWEYDEFERTVIQEAEE QGFKRYEIKISLNENCMLKAVRVYMVFEKLNEVGEVAKTIPSAEVLETEDFGTDFQVC FLTHQSAEDIEQLINGVSEIEHVEVIQGAPLTSAEKPEESKQEDSPAAAVPAKQEKQK QPAKNDEQAKHSAGGSKTIRVNIDRLDSLMNLFEELVIDRGRLEQIAKELEHNELTET VERMTRISGDLQSIILNMRMVPVETVFNRFPRMIRQLQKELNKKIELSIIGAETELDR TVIDEIGDPLVHLIRNSIDHGIEAPETRLQKGKPESGKVVLKAYHSGNHVFIEVEDDG AGLNRKKILEKALERGVITEKEAETLEDNQIYELIFAPGFSTADQISDISGRGVGLDV VKNKLESLGGSVSVKSAEGQGSLFSIQLPLTLSIISVLLIKLEEETFAIPISSIIETA VIDRKDILQTHDREVIDFRGHIVPVVYLKEEFKIEDTRKDAEQLHIIVVKKGDKPTAF VVDSFIGQQEVVLKSLGDYLTNVFAISGATILGDGEVALIIDCNALII*" /label="cheA CDS" gene 1586636..1588654 /gene="cheA" /locus_tag="BSU_16430" /old_locus_tag="BSU16430" /label="cheA gene" CDS 1588676..1589146 /gene="cheW" /locus_tag="BSU_16440" /old_locus_tag="BSU16440" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12864845, 15451661, 1624415, 8169223, 8169224" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12864845, 15451661, 1624415, 8169223, 8169224; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulation of CheA activity in response to attractants (chemotaxis)" /protein_id="NP_389526.1" /db_xref="EnsemblGenomes-Gn:BSU16440" /db_xref="EnsemblGenomes-Tr:CAB13517" /db_xref="GOA:P39802" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10692" /db_xref="UniProtKB/Swiss-Prot:P39802" /translation="MTAEIKTGEKMIVFMVNGKEYAISVTQVKSIEKWQKPTRVPGVE PYICGVINLRGVVTPVIDLRKRLNLPEYEITDETRIIIIAYRDIEVGWIVDEANDVIT VHESEIESAPEGVQKDTDVSIEQIVKQENRLLNIIDANAVLDKESSQSAVPDQA*" /label="cheW CDS" gene 1588676..1589146 /gene="cheW" /locus_tag="BSU_16440" /old_locus_tag="BSU16440" /label="cheW gene" CDS 1589165..1589794 /gene="cheC" /locus_tag="BSU_16450" /old_locus_tag="BSU16450" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12920116, 14749334, 14993307, 15546616, 16469702, 18990184, 22720735, 23226535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12920116, 14749334, 14993307, 15546616, 16469702, 18990184, 22720735, 23226535; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal terminating phosphatase of CheR-mediated methylation of methyl-accepting chemotaxis proteins (MCPs)" /protein_id="NP_389527.1" /db_xref="EnsemblGenomes-Gn:BSU16450" /db_xref="EnsemblGenomes-Tr:CAB13518" /db_xref="GOA:P40403" /db_xref="InterPro:IPR007597" /db_xref="InterPro:IPR028976" /db_xref="SubtiList:BG10749" /db_xref="UniProtKB/Swiss-Prot:P40403" /translation="MSIFNGIKEEQMDILREVGNIGAGHSASAMAQLLNRKIDMEVPF AKLLSFDELVDFFGGADVPVASIFLRMEGDLTGSMFFIMPFFQAEQFIRELIGNPDFD IEDLGEDHMSSSALHELGNILAGSYLTALADLTKLQLYPSVPEVSLDMFGAVISEGLM ELSQVGEHAIVVDTSIFDQSHQQELKAHMFMLPDYDSFEKLFVALGASL*" /label="cheC CDS" gene 1589165..1589794 /gene="cheC" /locus_tag="BSU_16450" /old_locus_tag="BSU16450" /label="cheC gene" CDS 1589791..1590291 /gene="cheD" /locus_tag="BSU_16460" /old_locus_tag="BSU16460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15546616, 16469702, 22720735, 23226535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15546616, 16469702, 22720735, 23226535; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sequence specific deamidase required for methylation of methyl-accepting chemotaxis proteins (MCPs) by CheR" /protein_id="NP_389528.1" /db_xref="EnsemblGenomes-Gn:BSU16460" /db_xref="EnsemblGenomes-Tr:CAB13519" /db_xref="GOA:P40404" /db_xref="InterPro:IPR005659" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG10750" /db_xref="UniProtKB/Swiss-Prot:P40404" /translation="MSTTEAVVIKVGIADVKIARFPDTIRTSGLGSCVGLVLYDKEKQ TAGLVHVMLPDSTLSKTAELNRAKYADTAVQTTIDMLIEAGCRKFALKAKLAGGSEMF KFKSTNDLMKIGPRNVLAIKEQLSLFNIPIISEDTGGSSGRTIEFEPKSCMLHIRTVK QGEKTI*" /label="cheD CDS" gene 1589791..1590291 /gene="cheD" /locus_tag="BSU_16460" /old_locus_tag="BSU16460" /label="cheD gene" CDS 1590314..1591078 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-28 factor (sigma-D)" /protein_id="NP_389529.1" /db_xref="EnsemblGenomes-Gn:BSU16470" /db_xref="EnsemblGenomes-Tr:CAB13520" /db_xref="GOA:P10726" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR012845" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10751" /db_xref="UniProtKB/Swiss-Prot:P10726" /translation="MQSLNYEDQVLWTRWKEWKDPKAGDDLMRRYMPLVTYHVGRISV GLPKSVHKDDLMSLGMLGLYDALEKFDPSRDLKFDTYASFRIRGAIIDGLRKEDWLPR TSREKTKKVEAAIEKLEQRYLRNVSPAEIAEELGMTVQDVVSTMNEGFFANLLSIDEK LHDQDDGENIQVMIRDDKNVPPEEKIMKDELIAQLAEKIHELSEKEQLVVSLFYKEEL TLTEIGQVLNLSTSRISQIHSKALFKLKNLLEKVIQ*" /label="sigD CDS" gene 1590314..1591078 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /label="sigD gene" promotor_-35 1591088..1591094 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" CDS 1591107..1591610 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15066026, 15175317, 19202088, 21736639, 26244495" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 15175317, 19202088, 21736639, 26244495; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling factor for flagellin transcription and translation" /protein_id="NP_389530.1" /db_xref="EnsemblGenomes-Gn:BSU16480" /db_xref="EnsemblGenomes-Tr:CAB13521" /db_xref="SubtiList:BG10752" /db_xref="UniProtKB/Swiss-Prot:P40405" /translation="MSTLLWLLSFMLHGVLLYAVIILYTRLAAVKETEKQQKQILEET ENTLAAFLLELKEENEKLIENKASSASQSDEESQKSGLQTSETYQERDPVQEAENLPE HIEGLITEVDRREELVNSEVQSFEDQVIELYEQGYSASQIAQKMKSGKTEIELFLKFR SKGVKDS*" /label="swrB CDS" gene 1591107..1591610 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /label="swrB gene" promotor_-10 1591109..1591120 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1591123 /Source="Nicolas_upshifts" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1591606..1591612 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1591627..1591646 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1591629..1591753 /Source="Nicolas_S_feature" /locus_tag="new_1717808_1717932" /HighExp="GM 45, GM 15, H2O2, M9-exp, LBGexp, C30, MG 90, GM-0.1, G135, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S586" upshifts 1591629 /Source="Nicolas_upshifts" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1591754..1592494 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9090122, 10675340, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S2" /protein_id="NP_389531.1" /db_xref="EnsemblGenomes-Gn:BSU16490" /db_xref="EnsemblGenomes-Tr:CAB13522" /db_xref="GOA:P21464" /db_xref="InterPro:IPR001865" /db_xref="InterPro:IPR005706" /db_xref="InterPro:IPR018130" /db_xref="InterPro:IPR023591" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19004" /db_xref="UniProtKB/Swiss-Prot:P21464" /translation="MSVISMKQLLEAGVHFGHQTRRWNPKMKRYIFTERNGIYIIDLQ KTVKKVEEAYNFTKNLAAEGGKILFVGTKKQAQDSVKEEAQRSGMYYVNQRWLGGTLT NFETIQKRIKRLKDIEKMQENGTFDVLPKKEVVQLKKELERLEKFLGGIKDMKDLPDA LFIIDPRKERIAVAEARKLNIPIIGIVDTNCDPDEIDVVIPANDDAIRAVKLLTSKMA DAILEAKQGEEEAEVAEETAPETETTTA*" /label="rpsB CDS" gene 1591754..1592494 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /label="rpsB gene" downshifts 1592476 /Source="Nicolas_upshifts" /id="D896" /incds=0 /nref=4 /ntot=61 /MaxReadThrough="9.04923" /MaxDrop="4.1312" /score="7.42766835" /energy="-14.3" /TU="U1324,U1328" /idTUdmin="U1323" /TUdmin=869 /isTUend="FALSE" /label="downshifts" S_feature 1592521..1592595 /Source="Nicolas_S_feature" /locus_tag="new_1718700_1718774" /HighExp="LPh, dia0, G150, G180, LBGexp, Lbexp, HPh, Oxctl, dia15, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S587" CDS 1592596..1593477 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6396082, 9244380, 9973356, 27624934; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor Ts" /protein_id="NP_389532.1" /db_xref="EnsemblGenomes-Gn:BSU16500" /db_xref="EnsemblGenomes-Tr:CAB13523" /db_xref="GOA:P80700" /db_xref="InterPro:IPR001816" /db_xref="InterPro:IPR009060" /db_xref="InterPro:IPR014039" /db_xref="InterPro:IPR018101" /db_xref="InterPro:IPR036402" /db_xref="SubtiList:BG19025" /db_xref="UniProtKB/Swiss-Prot:P80700" /translation="MAITAQQVKELREKTGAGMMDCKKALTETDGDMDKAIDLLREKG IAKAAKKADRIAAEGSTLIKTDGNKGVILEVNSETDFVAKNEGFKELLNTLADHLLAN TPADVEEAMGQKMENGSTVEEYITSAVAKIGEKITLRRFTVLTKDDSSAFGAYLHMGG RIGVLTVLNGTTDEETAKDIAMHVAAVNPRYISRDQVSEEETNHERQILTQQALQEGK PENIVAKMVEGRLNKFFEEICLLDQAFVKNPDEKVKQVIAAKNATVQTFVRYEVGEGI EKRQENFAEEVMNQVKK*" /label="tsf CDS" gene 1592596..1593477 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /label="tsf gene" S_feature 1593478..1593622 /Source="Nicolas_S_feature" /locus_tag="new_1719657_1719801" /HighExp="LBGexp, G150, LBGtran, G135, G180, LPh, Oxctl, dia0, Lbexp, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S588" CDS 1593623..1594345 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /EC_number="2.7.4.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9862121, 12682299, 12869195, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9862121, 12682299, 12869195, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridylate kinase" /protein_id="NP_389533.2" /db_xref="EnsemblGenomes-Gn:BSU16510" /db_xref="EnsemblGenomes-Tr:CAB13524" /db_xref="GOA:O31749" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR011817" /db_xref="InterPro:IPR015963" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12675" /db_xref="UniProtKB/Swiss-Prot:O31749" /translation="MEKPKYKRIVLKLSGEALAGEQGNGINPTVIQSIAKQVKEIAEL EVEVAVVVGGGNLWRGKTGSDLGMDRATADYMGMLATVMNSLALQDSLETLGIQSRVQ TSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILM AKNNVDGVYNADPRKDESAVKYESLSYLDVLKDGLEVMDSTASSLCMDNDIPLIVFSI MEEGNIKRAVIGESIGTIVRGK*" /label="pyrH CDS" gene 1593623..1594345 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /label="pyrH gene" CDS 1594347..1594904 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9862121, 12480895, 12682299, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome recycling factor" /protein_id="NP_389534.1" /db_xref="EnsemblGenomes-Gn:BSU16520" /db_xref="EnsemblGenomes-Tr:CAB13525" /db_xref="GOA:P81101" /db_xref="InterPro:IPR002661" /db_xref="InterPro:IPR023584" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12587" /db_xref="UniProtKB/Swiss-Prot:P81101" /translation="MSKEVLTQTKEKMEKAIAAYQRELATVRAGRANPSLLDKVTVEY YGAQTPLNQLSSINVPEARMLVITPYDKTAIGDIEKAILKADLGLTPTSDGNMIRIAI PALTEERRKELVKVVKKYAEEAKVAVRNVRRDANDDLKKLEKNGDITEDELRASTEDV QKLTDEYVSKIDSVTKDKEKEIMEV*" /label="frr CDS" gene 1594347..1594904 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /label="frr gene" downshifts complement(1594851) /Source="Nicolas_upshifts" /id="D897" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="3.38183" /MaxDrop="3.17183" /score="-5.69560888" /energy="-4.8" /TU="NA" /idTUdmin="U1326" /TUdmin="-10739" /isTUend="FALSE" /label="downshifts" promotor_-35 1594893..1594896 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1594911..1594930 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1594929..1595034 /Source="Nicolas_S_feature" /locus_tag="new_1721108_1721213" /HighExp="G180, G135, T3.30H, Oxctl, G150, Cold, Paraq, C30, T3.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S589" upshifts 1594929 /Source="Nicolas_upshifts" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1595035..1595817 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /EC_number="2.5.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15788389, 16014871, 22904278, 23840410, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15788389, 16014871, 22904278, 23840410, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate synthase" /protein_id="NP_389535.1" /db_xref="EnsemblGenomes-Gn:BSU16530" /db_xref="EnsemblGenomes-Tr:CAB13526" /db_xref="GOA:O31751" /db_xref="InterPro:IPR001441" /db_xref="InterPro:IPR018520" /db_xref="InterPro:IPR036424" /db_xref="SubtiList:BG13408" /db_xref="UniProtKB/Swiss-Prot:O31751" /translation="MLNILKNWKNQQTAASNLERYTKEDILKGEIPEHIAIIMDGNGR WAKKRSLPRIAGHHEGMKVVKRTTKLANELGVKVLTLYAFSTENWKRPKMEVDFLMKL PEEFLNTYLPELVEENVQVRIIGDETALPAHTLRAIEKAVQDTAQNDGMILNFALNYG GRTEIVSAAKSLAEKVKEGSLNIEDIDESLFSTYLMTESLQDPELLIRTSGEIRLSNF MLWQVAYSEFVFTDVLWPDFKEDHFLQALGEFQQRGRRFGGI*" /label="uppS CDS" gene 1595035..1595817 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /label="uppS gene" CDS 1595821..1596630 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /EC_number="2.7.7.41" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 175832, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidate cytidylyltransferase (CDP-diglyceride synthase)" /protein_id="NP_389536.1" /db_xref="EnsemblGenomes-Gn:BSU16540" /db_xref="EnsemblGenomes-Tr:CAB13527" /db_xref="GOA:O31752" /db_xref="InterPro:IPR000374" /db_xref="SubtiList:BG12575" /db_xref="UniProtKB/Swiss-Prot:O31752" /translation="MVDMKQRILTGVLAAIVFLFLVIVGKLPFTILIYAMGSVALFEL LRMKKLKLVSLPGLIGLLLLWMFLLPSQYSFFEADGISKMEIALFAVLLLLTYTVLVK NTFTFDEVGFITLAAIYIGMCFHYFIEIRNLDQYGLTYIFYACVVIWSTDSGAYFVGK SLGKRKLWPEISPNKTVEGFAGGIVIALVLATIFQLVAQLPIPYIYLLLITLFLSVFG QLGDLVESALKRHYDVKDSGNILPGHGGILDRFDSFLFVMPFLYFLLALFS*" /label="cdsA" gene 1595821..1596630 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /label="cdsA gene" promotor_-35 1596611..1596618 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1596633..1596652 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1596634 /Source="Nicolas_upshifts" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1596692..1597843 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /EC_number="1.1.1.267" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15567415, 17458547, 21296950, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15567415, 17458547, 21296950, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase" /protein_id="NP_389537.2" /db_xref="EnsemblGenomes-Gn:BSU16550" /db_xref="EnsemblGenomes-Tr:CAB13528" /db_xref="GOA:O31753" /db_xref="InterPro:IPR003821" /db_xref="InterPro:IPR013512" /db_xref="InterPro:IPR013644" /db_xref="InterPro:IPR026877" /db_xref="InterPro:IPR036169" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13409" /db_xref="UniProtKB/Swiss-Prot:O31753" /translation="MKNICLLGATGSIGEQTLDVLRAHQDQFQLVSMSFGRNIDKAVP MIEVFQPKFVSVGDLDTYHKLKQMSFSFECQIGLGEEGLIEAAVMEEVDIVVNALLGS VGLIPTLKAIEQKKTIALANKETLVTAGHIVKEHAKKYDVPLLPVDSEHSAIFQALQG EQAKNIERLIITASGGSFRDKTREELESVTVEDALKHPNWSMGAKITIDSATMMNKGL EVIEAHWLFDIPYEQIDVVLHKESIIHSMVEFHDKSVIAQLGTPDMRVPIQYALTYPD RLPLPDAKRLELWEIGSLHFEKADFDRFRCLQFAFESGKIGGTMPTVLNAANEVAVAA FLAGKIPFLAIEDCIEKALTRHQLLKKPSLADIQEVDKDTRGYVNSILT*" /label="dxr CDS" gene 1596692..1597843 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /label="dxr gene" CDS 1597850..1599118 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /EC_number="3.4.24.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inner membrane zinc metalloprotease required forthe extracytoplasmic stress response mediated by sigma(W)" /protein_id="NP_389538.1" /db_xref="EnsemblGenomes-Gn:BSU16560" /db_xref="EnsemblGenomes-Tr:CAB13529" /db_xref="GOA:O31754" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR004387" /db_xref="InterPro:IPR008915" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG13410" /db_xref="UniProtKB/Swiss-Prot:O31754" /translation="MFVNTVIAFIIIFGTLVFFHELGHLLLAQRAGILCREFAIGFGP KIFSFKKNETVYTIRLLPVGGFVRMAGEDPEMIEVKPGYTVGLLFNKEDQVEKVIINQ KEKYPDALVIEVETADLEHDMKITGYEQGKEDELSSFTVSETSFFIVDGEEVQIAPYN RQFGSKPVWQRIKAIAAGPIMNFILAYVILVMLGLIQGVPSNEPMLGQLTDNGRAAEA GLKEGDYIQSINGEKMRSWTDIVSAVKENPEKEMDVAVKRDNKTLHISVTPEAVKDEN KKTIGRFGSYAPTEKGVLSAVAYGATSTVDVTKAILTNLSKLVTGQFKLDMLSGPVGI YDMTDQVAKTGIVNLFQFAAFLSINLGIVNLLPIPALDGGRLLFLFIEAIRGKPINRE KEAFVVFIGVAFLMLLMLVVTWNDIQRLFL*" /label="rasP CDS" gene 1597850..1599118 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /label="rasP gene" CDS 1599151..1600845 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /EC_number="6.1.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16864571, 26886480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl-tRNA synthetase" /protein_id="NP_389539.1" /db_xref="EnsemblGenomes-Gn:BSU16570" /db_xref="EnsemblGenomes-Tr:CAB13530" /db_xref="GOA:O31755" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002316" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004500" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR023717" /db_xref="InterPro:IPR033730" /db_xref="InterPro:IPR036621" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12659" /db_xref="UniProtKB/Swiss-Prot:O31755" /translation="MRQSLTLIPTLREVPADAEAKSHQLLLRAGFIRQNTSGVYSYMP LAYKVIQNIQQIVREEMEKIDAVEMLMPALQQAETWQESGRWYTYGPELMRLKDRHGR EFALGATHEEVITSLVRDEVKSYKRLPLTLYQIQSKFRDEKRPRFGLLRGREFIMKDA YSFHASAESLDETYQKMYEAYSNIFARCGINVRPVIADSGAMGGKDTHEFMALSAIGE DTIAYSDESQYAANIEMAEVLHQEVPSDEEPKALEKVHTPNVKTIEELTAFLQVSAEA CIKSVLFKADDRFVLVLVRGDHEVNDIKVKNLLHAEVVELATHEEVIQQLGTEPGFVG PVGIHQDVEVYADQAVKAMVNAVAGANEGDHHYKNVNVNRDAQIKEFADLRFIKEGDP SPDGKGTIRFAEGIEVGQVFKLGTRYSEAMNATYLDENGRAQPMLMGCYGIGVSRTLS AIAEQHHDEKGLIWPKSVAPYDLHILALNMKNDGQRELAEKLYADLKAEGYEVLYDDR AERAGVKFADSDLIGLPIRITVGKRADEGIVEVKIRQTGESTEISVDELSAFISKQ*" /label="proS CDS" gene 1599151..1600845 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /label="proS gene" S_feature 1600846..1600953 /Source="Nicolas_S_feature" /locus_tag="new_1727025_1727132" /HighExp="G135, G180, G150, C30, Oxctl, H2O2, Paraq, LPh, LBGexp, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S590" CDS 1600954..1605267 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit)" /protein_id="NP_389540.1" /db_xref="EnsemblGenomes-Gn:BSU16580" /db_xref="EnsemblGenomes-Tr:CAB13531" /db_xref="GOA:P13267" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006308" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR024754" /db_xref="InterPro:IPR028112" /db_xref="InterPro:IPR029460" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG10263" /db_xref="UniProtKB/Swiss-Prot:P13267" /translation="MEQLSVNRRQFQILLQQINMTDDTFMTYFEHGEIKKLTIHKASK SWHFHFQFKSLLPFQIYDTLTTRLTQSFAHIAKVTSSIEVQDAEVSESIVQDYWSRCI EELQGISPPIISLLNQQKPKLKGNKLIVKTKTDTEAAALKNKYSSMIQAEYRQFGFPD LQLDAEIFVSEQEVQKFREQKLAEDQERAMQALIEMEKKDKESDEDQAPSGPLVIGYQ IKDNEEIRTLDSIMDEERRITVQGYVFDVETRELKSGRTLCIFKITDYTNSILIKMFA REKEDAALMKSLKKGMWVKARGSIQNDTFVRDLVMIANDVNEIKAKTREDSAPEGEKR VELHLHSPMSQMDAVTGIGKLVEQAKKWGHEAIALTDHAVVQSFPDAYSAAKKHGIKM IYGMEANLVDDGVPIAYNAAHRLLEEETYVVFDVETTGLSAVYDTIIELAAVKVKGGE IIDKFEAFANPHRPLSATIIELTGITDDMLQDAPDVVDVIRDFREWIGDDILVAHNAS FDMGFLNVAYKKLLEVEKAKNPVIDTLELGRFLYPEFKNHRLNTLCKKFDIELTQHHR AIYDTEATAYLLLKMLKDAAEKGIQYHDELNENMGQSNAYQRSRPYHATLLAVNSTGL KNLFKLVSLSHIHYFYRVPRIPRSQLEKYREGLLIGSACDRGEVFEGMMQKSPEEVED IASFYDYLEVQPPEVYRHLLELELVRDEKALKEIIANITKLGEKLNKPVVATGNVHYL NDEDKIYRKILISSQGGANPLNRHELPKVHFRTTDEMLEAFSFLGEEKAKEIVVTNTQ KVASLVDDIKPIKDDLYTPKIEGADEEIREMSYQRARSIYGEELPEIVEARIEKELKS IIGHGFAVIYLISHKLVKRSLDDGYLVGSRGSVGSSLVATLTEITEVNPLPPHYVCPE CQHSEFFNDGSVGSGFDLPDKTCPHCGTPLKKDGHDIPFETFLGFKGDKVPDIDLNFS GEYQPQAHNYTKVLFGEDNVYRAGTIGTVAEKTAYGYVKGYAGDNNLHMRGAEIDRLV QGCTGVKRTTGQHPGGIIVVPDYMDIYDFSPIQFPADATGSEWKTTHFDFHSIHDNLL KLDILGHDDPTVIRMLQDLSGIDPKTIPTDDPEVMKIFQGTESLGVTEEQIGCKTGTL GIPEFGTRFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIHNNICELSEVIG CRDDIMVYLIYQGLEPSLAFKIMEFVRKGKGLTPEWEEEMKNNNVPDWYIDSCKKIKY MFPKAHAAAYVLMAVRIAYFKVHHALLYYAAYFTVRADDFDIDTMIKGSTAIRAVMED INAKGLDASPKEKNLLTVLELALEMCERGYSFQKVDLYRSSATEFIIDGNSLIPPFNS IPGLGTNAALNIVKAREEGEFLSKEDLQKRGKVSKTILEYLDRHGCLESLPDQNQLSL F*" /label="polC CDS" gene 1600954..1605267 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /label="polC gene" S_feature 1605268..1605332 /Source="Nicolas_S_feature" /locus_tag="new_1731447_1731511" /HighExp="C30, G180, G135, Oxctl, G150, H2O2, Paraq, Cold, LBGstat, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S591" misc_RNA 1605278..1605495 /gene="surG" /locus_tag="BSU_misc_RNA_71" /product="small RNAs controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surG RNA" gene 1605278..1605495 /gene="surG" /locus_tag="BSU_misc_RNA_71" /label="surG gene" promotor_-35 1605304..1605310 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-35" promotor_-10 1605325..1605336 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-10" S_feature 1605334..1605401 /Source="Nicolas_S_feature" /locus_tag="new_1731513_1731580" /HighExp="S7, S5, S4, S8, S6, S3, G180, C30, T5.0H, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S592" upshifts 1605334 /Source="Nicolas_upshifts" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="upshifts" promotor_-35 1605384..1605390 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-35" S_feature 1605403..1605596 /Source="Nicolas_S_feature" /locus_tag="new_1731582_1731775" /HighExp="LoTm, Cold, HPh, G180, Paraq, Oxctl, T-5.40H, BMM, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S593" upshifts 1605403 /Source="Nicolas_upshifts" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="upshifts" promotor_-10 1605404..1605423 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-10" CDS 1605597..1606067 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15257761, 16014871, 19150615, 20188109, 21529161; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome maturation factor" /protein_id="NP_389541.1" /db_xref="EnsemblGenomes-Gn:BSU16590" /db_xref="EnsemblGenomes-Tr:CAB13532" /db_xref="GOA:P32726" /db_xref="InterPro:IPR003728" /db_xref="InterPro:IPR028989" /db_xref="InterPro:IPR028998" /db_xref="InterPro:IPR035956" /db_xref="InterPro:IPR036847" /db_xref="SubtiList:BG10264" /db_xref="UniProtKB/Swiss-Prot:P32726" /translation="MSKKVTDTVQEMAQPIVDSLQLELVDIEFVKEGQSWFLRVFIDS DDGVDIEECAKVSEALSEKLDEADPISQNYFLEVSSPGAERPLKKKADFEKSLGKNVY IKTYEPIDGVKVFEGELAEFDGQTVTVEITIKTRKKRINIPYEKIANARLAVTF*" /label="rimP CDS" gene 1605597..1606067 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /label="rimP gene" downshifts complement(1605918) /Source="Nicolas_upshifts" /id="D898" /incds=1 /nref=3 /ntot=136 /MaxReadThrough="2.08299" /MaxDrop="3.17419" /score="-8.18111474" /energy="-9.2" /TU="NA" /idTUdmin="U1333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1606102..1607217 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15978071, 16707701, 16946247, 27571753, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15978071, 16707701, 16946247, 27571753, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="transcription translation coupling factor involved in Rho-dependent transcription termination" /protein_id="NP_389542.1" /db_xref="EnsemblGenomes-Gn:BSU16600" /db_xref="EnsemblGenomes-Tr:CAB13533" /db_xref="GOA:P32727" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR010213" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013735" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR025249" /db_xref="InterPro:IPR030842" /db_xref="InterPro:IPR036555" /db_xref="PDB:2MT4" /db_xref="SubtiList:BG10265" /db_xref="UniProtKB/Swiss-Prot:P32727" /translation="MSSELLDALTILEKEKGISKEIIIEAIEAALISAYKRNFNQAQN VRVDLNRETGSIRVFARKDVVDEVYDQRLEISIEEAQGIHPEYMVGDVVEIEVTPKDF GRIAAQTAKQVVTQRVREAERGVIYSEFIDREEDIMTGIVQRLDNKFIYVSLGKIEAL LPVNEQMPNESYKPHDRIKVYITKVEKTTKGPQIYVSRTHPGLLKRLFEIEVPEIYDG TVELKSVAREAGDRSKISVRTDDPDVDPVGSCVGPKGQRVQAIVNELKGEKIDIVNWS SDPVEFVANALSPSKVLDVIVNEEEKATTVIVPDYQLSLAIGKRGQNARLAAKLTGWK IDIKSETDARELGIYPRELEEDDEPLFTEPETAESDE*" /label="nusA CDS" gene 1606102..1607217 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /label="nusA gene" promotor_no_box complement(1606164..1606264) /Source="Nicolas_upshift_promotors" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1606204) /Source="Nicolas_upshifts" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1607231..1607506 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11679764, 12682299, 26771646, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular ruler co-factor for RNA; new fold" /protein_id="NP_389543.1" /db_xref="EnsemblGenomes-Gn:BSU16610" /db_xref="EnsemblGenomes-Tr:CAB13534" /db_xref="InterPro:IPR007393" /db_xref="InterPro:IPR035931" /db_xref="SubtiList:BG10266" /db_xref="UniProtKB/Swiss-Prot:P32728" /translation="MNKHKKIPLRKCVVTGEMKPKKELIRVVRSKEGEISVDPTGKKN GRGAYLTLDKECILAAKKKNTLQNQFQSQIDDQIFDELLELAEKVKK*" /label="rulR CDS" gene 1607231..1607506 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /label="rulR gene" CDS 1607508..1607810 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15130481, 15361074, 22355167, 26522935, 26771646" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130481, 15361074, 22355167, 26522935, 26771646; Product type f: factor" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein" /protein_id="NP_389544.1" /db_xref="EnsemblGenomes-Gn:BSU16620" /db_xref="EnsemblGenomes-Tr:CAB13535" /db_xref="GOA:P32729" /db_xref="InterPro:IPR004037" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7Q" /db_xref="SubtiList:BG10267" /db_xref="UniProtKB/Swiss-Prot:P32729" /translation="MSGMEWFPLLGLANRARKVVSGEDLVIKEIRNARAKLVLLTEDA SSNTAKKVTDKCNYYKVPYKKVESRAVLGRSIGKEARVVVAVTDQGFANKLISLLD*" /label="rulQ CDS" gene 1607508..1607810 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /label="rulQ gene" CDS 1607830..1609980 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1426242, 9588797, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1426242, 9588797, 12682299, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-2" /protein_id="NP_389545.1" /db_xref="EnsemblGenomes-Gn:BSU16630" /db_xref="EnsemblGenomes-Tr:CAB13536" /db_xref="GOA:P17889" /db_xref="InterPro:IPR000178" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006847" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR015760" /db_xref="InterPro:IPR023115" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036925" /db_xref="SubtiList:BG10268" /db_xref="UniProtKB/Swiss-Prot:P17889" /translation="MAKMRVYEYAKALNVSSKEILTALKNMDLEVNNHMAMLEEKAIK KLDAKYKKGGAAAKSQKPAETNKNKQPQGVNQQSAGNQPNKIRDGKKNDVQNNQFNKN KKNNNNKKNKRNNNNNKNQHQQKPVKPKKELPEKITFSGTLTVGALAEELGKEPSELI KKLMLLGVMATINQELDKDTIELIASEYGVETEEVIVLEETELEKYEEPDNEEDLEIR PPVVTIMGHVDHGKTTLLDSIRKTKVVEGEAGGITQHIGAYQIEENGKKITFLDTPGH AAFTTMRARGAEVTDITILVVAADDGVMPQTVEAINHAKAAEVPIIVAVNKIDKESAN PDRVMQELTEYGLVPEAWGGETIFVPLSALTGKGIDELVEMILLVSEVEELKANPNRQ AKGTVIEAELDKGRGSVATLLVQTGTLHVGDPIVVGNTFGRVRAMVNDIGRRVKTAGP STPVEITGLNDVPQAGDQFLVFKDEKTARSVGEARASKQLEEQRSDKAKLSLDDLFEQ IKQGDVKDINLIVKADVQGSAEALTAALQKIEVEGVKVKIIHTGVGAITESDIILASA SNAIVIGFNVRPDGNAKSTAEAENVDIRLHRIIYKVIDEIEAAMKGMLDPEYEEKVIG QVEVRQTFKVSKIGTIAGGYVTEGTITRDSGLRLIRDGVVIFEGEVDVLKRFKDDVKE VSQGYECGITIKKYNDIREGDILEAFVMQEIERT*" /label="infB CDS" gene 1607830..1609980 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /label="infB gene" promotor_-35 1609875..1609881 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1609890 /Source="Nicolas_upshifts" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1609896..1609914 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1609977..1610255 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of conserved protein" /db_xref="EnsemblGenomes-Gn:BSU16640" /db_xref="EnsemblGenomes-Tr:CAB13537" /db_xref="InterPro:IPR007546" /db_xref="InterPro:IPR036746" /db_xref="PSEUDO:CAB13537.1" /db_xref="SubtiList:BG10269" /db_xref="UniProtKB/Swiss-Prot:P32730" /translation="MIGFAECECIIYDAGSLKEKRAVLKRILTRVQNKFNVSISEIGY QDTWQRTSFGIAAVSSSRVQTEKELQRVLAFIDSFPEIERTITRTEWF*" /label="ylxP CDS" gene 1609977..1610255 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /pseudo /label="ylxP gene" CDS 1610272..1610625 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12628255, 15185964, 17996707, 21102555, 21529161, 23293003, 23611982, 24671761, 25904134, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="pre-ribosomal (17S) RNA binding factor A" /protein_id="NP_389547.1" /db_xref="EnsemblGenomes-Gn:BSU16650" /db_xref="EnsemblGenomes-Tr:CAB13538" /db_xref="GOA:P32731" /db_xref="InterPro:IPR000238" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020053" /db_xref="InterPro:IPR023799" /db_xref="SubtiList:BG10270" /db_xref="UniProtKB/Swiss-Prot:P32731" /translation="MSMRANRVGEQMKKELGDIISRKLKDPRIGFLTVTDVRVSGDLQ IAKVYISVLGDEKKREEALKGLAKAKGFIRSEIGSRIRLRKTPEIEFEFDESIDYGNR IETLIHELHSEKPSE*" /label="rbfA CDS" gene 1610272..1610625 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /label="rbfA gene" downshifts 1610616 /Source="Nicolas_upshifts" /id="D899" /incds=0 /nref=9 /ntot=130 /MaxReadThrough="6.97196" /MaxDrop="5.80207" /score="-3.06560848" /energy="-13.8" /TU="U1331,U1332,U1334" /idTUdmin="U1331" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" CDS 1610707..1611636 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /EC_number="5.4.99.25" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7489483, 15987897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine 55 synthase" /protein_id="NP_389548.1" /db_xref="EnsemblGenomes-Gn:BSU16660" /db_xref="EnsemblGenomes-Tr:CAB13539" /db_xref="GOA:P32732" /db_xref="InterPro:IPR002501" /db_xref="InterPro:IPR014780" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR032819" /db_xref="SubtiList:BG10271" /db_xref="UniProtKB/Swiss-Prot:P32732" /translation="MVNGVLLLHKPVGMTSHDCVMKIRKLLKTKKVGHTGTLDPEVSG VLPICVGRATKIVEYLTEKSKTYDAEITLGFSTTTEDQTGETVETKPVNHDIDKADVE KVLNSLKGKQEQIPPMYSAVKVNGKKLYEYARAGIEVERPKRMITIEDIALTTEIKHH GETASFRFTVTCSKGTYVRTLAVMIGEKLGYPAHMSHLIRTASGDFSLDECFTFDELE AQAQSGTVEEHTVPIERALNHLPKWIISDTLAKKVENGALLETPEQFSEMTSGDRIAV FTESGTCLAIYFPHPAKKGLLKPAKVLMQKSEQ*" /label="truB CDS" gene 1610707..1611636 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /label="truB gene" promotor_-35 1611421..1611428 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1611442..1611461 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1611451 /Source="Nicolas_upshifts" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1611655..1612605 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /EC_number="2.7.1.26" /EC_number="2.7.7.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9473052, 10206712, 12456892, 15668000, 18156273, 21866869" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9473052, 10206712, 12456892, 15668000, 18156273, 21866869; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="bifunctional riboflavin kinase FAD synthase" /protein_id="NP_389549.1" /db_xref="EnsemblGenomes-Gn:BSU16670" /db_xref="EnsemblGenomes-Tr:CAB13540" /db_xref="GOA:P54575" /db_xref="InterPro:IPR002606" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015864" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11495" /db_xref="UniProtKB/Swiss-Prot:P54575" /translation="MKTIHITHPHHLIKEEQAKSVMALGYFDGVHLGHQKVIGTAKQI AEEKGLTLAVMTFHPHPSHVLGRDKEPKDLITPLEDKINQIEQLGTEVLYVVKFNEVF ASLSPKQFIDQYIIGLNVQHAVAGFDFTYGKYGKGTMKTMPDDLDGKAGCTMVEKLTE QDKKISSSYIRTALQNGDVELANVLLGQPYFIKGIVIHGDKRGRTIGFPTANVGLNNS YIVPPTGVYAVKAEVNGEVYNGVCNIGYKPTFYEKRPEQPSIEVNLFDFNQEVYGAAI KIEWYKRIRSERKFNGIKELTEQIEKDKQEAIRYFSNLRK*" /label="ribC CDS" gene 1611655..1612605 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /label="ribC gene" promotor_-35 1612638..1612644 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1612645..1612761 /Source="Nicolas_S_feature" /locus_tag="new_1738824_1738940" /HighExp="SMM, GM 15, Salt, T-4.40H, GM 45, T-5.40H, GM 60, MG 45, LPhT, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S594" upshifts 1612645 /Source="Nicolas_upshifts" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1612659..1612678 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1612762..1613031 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15627386, 8825778, 20418391, 22720735, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15627386, 8825778, 20418391, 22720735, 23611891; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S15 (BS18)" /protein_id="NP_389550.1" /db_xref="EnsemblGenomes-Gn:BSU16680" /db_xref="EnsemblGenomes-Tr:CAB13541" /db_xref="GOA:P21473" /db_xref="InterPro:IPR000589" /db_xref="InterPro:IPR005290" /db_xref="InterPro:IPR009068" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19010" /db_xref="UniProtKB/Swiss-Prot:P21473" /translation="MAITQERKNQLINEFKTHESDTGSPEVQIAILTDSINNLNEHLR THKKDHHSRRGLLKMVGKRRNLLTYLRNKDVTRYRELINKLGLRR*" /label="rpsO CDS" gene 1612762..1613031 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /label="rpsO gene" downshifts 1613014 /Source="Nicolas_upshifts" /id="D900" /incds=0 /nref=30 /ntot=154 /MaxReadThrough="8.65904" /MaxDrop="5.6648" /score="29.9198852" /energy="-10.2" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1331" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" S_feature 1613059..1613144 /Source="Nicolas_S_feature" /locus_tag="new_1739238_1739323" /HighExp="Cold, LoTm, Oxctl, G180, H2O2, G150, dia15, Paraq, LPh, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S595" promotor_-35 1613125..1613128 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1613144..1613163 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1613146 /Source="Nicolas_upshifts" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1613204..1615321 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /EC_number="2.7.7.8" /EC_number="3.1.13.1" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polynucleotide phosphorylase (PNPase)" /protein_id="NP_389551.1" /db_xref="EnsemblGenomes-Gn:BSU16690" /db_xref="EnsemblGenomes-Tr:CAB13542" /db_xref="GOA:P50849" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR012162" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR015848" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="InterPro:IPR036456" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG11491" /db_xref="UniProtKB/Swiss-Prot:P50849" /translation="MGQEKHVFTIDWAGRTLTVETGQLAKQANGAVMIRYGDTAVLST ATASKEPKPLDFFPLTVNYEERLYAVGKIPGGFIKREGRPSEKAVLASRLIDRPIRPL FADGFRNEVQVISIVMSVDQNCSSEMAAMFGSSLALSVSDIPFEGPIAGVTVGRIDDQ FIINPTVDQLEKSDINLVVAGTKDAINMVEAGADEVPEEIMLEAIMFGHEEIKRLIAF QEEIVAAVGKEKSEIKLFEIDEELNEKVKALAEEDLLKAIQVHEKHAREDAINEVKNA VVAKFEDEEHDEDTIKQVKQILSKLVKNEVRRLITEEKVRPDGRGVDQIRPLSSEVGL LPRTHGSGLFTRGQTQALSVCTLGALGDVQILDGLGVEESKRFMHHYNFPQFSVGETG PMRGPGRREIGHGALGERALEPVIPSEKDFPYTVRLVSEVLESNGSTSQASICASTLA MMDAGVPIKAPVAGIAMGLVKSGEHYTVLTDIQGMEDALGDMDFKVAGTEKGVTALQM DIKIEGLSREILEEALQQAKKGRMEILNSMLATLSESRKELSRYAPKILTMTINPDKI RDVIGPSGKQINKIIEETGVKIDIEQDGTIFISSTDESGNQKAKKIIEDLVREVEVGQ LYLGKVKRIEKFGAFVEIFSGKDGLVHISELALERVGKVEDVVKIGDEILVKVTEIDK QGRVNLSRKAVLREEKEKEEQQS*" /label="pnpA CDS" gene 1613204..1615321 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /label="pnpA gene" downshifts 1615104 /Source="Nicolas_upshifts" /id="D901" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.05841" /MaxDrop="3.82025" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336,U1337" /idTUdmin="U1337" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 1615305 /Source="Nicolas_upshifts" /id="D902" /incds=0 /nref=192 /ntot=270 /MaxReadThrough="5.61214" /MaxDrop="6.82185" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1337" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature 1615350..1615438 /Source="Nicolas_S_feature" /locus_tag="new_1741529_1741617" /HighExp="G135, G180, G150, H2O2, Oxctl, LBGexp, Paraq, LoTm, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S596" CDS 1615439..1616398 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14679227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar deacetylase" /protein_id="NP_389552.1" /db_xref="EnsemblGenomes-Gn:BSU16700" /db_xref="EnsemblGenomes-Tr:CAB13543" /db_xref="GOA:P50850" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR010916" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014228" /db_xref="SubtiList:BG11492" /db_xref="UniProtKB/Swiss-Prot:P50850" /translation="MYKKFVPFAVFLFLFFVSFEMMENPHALDYIGAMKKDTVTVTAS KDPLYEELLQKAPEYEVKPQNARIDKVWKSIPGYNGLKVNIEQSYKKMKQHGKFREKD LVYSQVKPSVHLESLQPEPIYKGNPDKPMVAFLINVAWGNEYLEKMLPILQKHQVKAT FFLEGNWVRNNVQLAKKIAKDGHEIGNHSYNHPDMSKLTTGRISEQLDKTNEQIEQTI GVKPKWFAPPSGSFRKAVIDIAAEKQMGTVMWTVDTIDWQKPAPSVLQTRVLSKIHNG AMILMHPTDPTAESLEALITQIKDKGYALGTVTELMDETRLLK*" /label="ylxY CDS" gene 1615439..1616398 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /label="ylxY gene" promotor_-10 complement(1615507..1615515) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1615510) /Source="Nicolas_upshifts" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1615529..1615536) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1616002..1616007 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1616023..1616041 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1616028 /Source="Nicolas_upshifts" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1616438..1617667 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10666719, 10974125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666719, 10974125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="specific processing protease" /protein_id="NP_389553.2" /db_xref="EnsemblGenomes-Gn:BSU16710" /db_xref="EnsemblGenomes-Tr:CAB13544" /db_xref="GOA:Q04805" /db_xref="InterPro:IPR001431" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG10779" /db_xref="UniProtKB/Swiss-Prot:Q04805" /translation="MIKRYTCQNGVRIVLENNPTVRSVAIGVWIGTGSRHETPEINGI SHFLEHMFFKGTSTKSAREIAESFDRIGGQVNAFTSKEYTCYYAKVLDEHANYALDVL ADMFFHSTFDENELKKEKNVVYEEIKMYEDAPDDIVHDLLSKATYGNHSLGYPILGTE ETLASFNGDSLRQYMHDYYTPDRVVISVAGNISDSFIKDVEKWFGSYEAKGKATGLEK PEFHTEKLTRKKETEQAHLCLGFKGLEVGHERIYDLIVLNNVLGGSMSSRLFQDVRED KGLAYSVYSYHSSYEDSGMLTIYGGTGANQLQQLSETIQETLATLKRDGITSKELENS KEQMKGSLMLSLESTNSKMSRNGKNELLLGKHKTLDEIINELNAVNLERVNGLARQLF TEDYALALISPSGNMPS*" /label="mlpA CDS" gene 1616438..1617667 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /label="mlpA gene" downshifts 1617656 /Source="Nicolas_upshifts" /id="D903" /incds=0 /nref=140 /ntot=219 /MaxReadThrough="1.31218" /MaxDrop="4.84427" /score="15.1952611" /energy="-12.6" /TU="NA" /idTUdmin="U1336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1617696..1617701 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1617711 /Source="Nicolas_upshifts" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1617717..1617735 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1617745..1618002 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /experiment="publication(s) with functional evidences, PMID:23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="PRC barrel protein involved in sporulation" /protein_id="NP_389554.1" /db_xref="EnsemblGenomes-Gn:BSU16720" /db_xref="EnsemblGenomes-Tr:CAB13545" /db_xref="GOA:Q04811" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG10780" /db_xref="UniProtKB/Swiss-Prot:Q04811" /translation="MRLSELSGKEIVDIKRAERLGVLGQTDLEINEQDGQITALLIPT VKWFGLRKQGHDIRVPWHHIQKIGSDMIILDVPEEMPPRQE*" /label="ymxH CDS" gene 1617745..1618002 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /label="ymxH gene" S_feature 1618003..1618057 /Source="Nicolas_S_feature" /locus_tag="new_1744182_1744236" /HighExp="S4, S3, S5, S6, S8, S7, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S597" downshifts 1618030 /Source="Nicolas_upshifts" /id="D904" /incds=0 /nref=41 /ntot=56 /MaxReadThrough="0.534319999999999" /MaxDrop="6.36032" /score="29.434739" /energy="-11.7" /TU="NA" /idTUdmin="U1340" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1618099..1618108 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-35" S_feature 1618118..1618187 /Source="Nicolas_S_feature" /locus_tag="new_1744297_1744366" /HighExp="S6, S8, S7, BT, B36, S5, G/S, Pyr, B60, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S598" upshifts 1618118 /Source="Nicolas_upshifts" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="upshifts" promotor_-10 1618122..1618141 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-10" CDS 1618188..1619081 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /EC_number="1.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit A" /protein_id="NP_389555.1" /db_xref="EnsemblGenomes-Gn:BSU16730" /db_xref="EnsemblGenomes-Tr:CAB13546" /db_xref="GOA:Q04809" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR014215" /db_xref="InterPro:IPR031629" /db_xref="InterPro:IPR036291" /db_xref="PDB:2RIR" /db_xref="SubtiList:BG10781" /db_xref="UniProtKB/Swiss-Prot:Q04809" /translation="MLTGLKIAVIGGDARQLEIIRKLTEQQADIYLVGFDQLDHGFTG AVKCNIDEIPFQQIDSIILPVSATTGEGVVSTVFSNEEVVLKQDHLDRTPAHCVIFSG ISNAYLENIAAQAKRKLVKLFERDDIAIYNSIPTVEGTIMLAIQHTDYTIHGSQVAVL GLGRTGMTIARTFAALGANVKVGARSSAHLARITEMGLVPFHTDELKEHVKDIDICIN TIPSMILNQTVLSSMTPKTLILDLASRPGGTDFKYAEKQGIKALLAPGLPGIVAPKTA GQILANVLSKLLAEIQAEEGK*" /label="spoVFA CDS" gene 1618188..1619081 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /label="spoVFA gene" CDS 1619084..1619686 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit B" /protein_id="NP_389556.1" /db_xref="EnsemblGenomes-Gn:BSU16740" /db_xref="EnsemblGenomes-Tr:CAB13547" /db_xref="GOA:Q04810" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR014214" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG10782" /db_xref="UniProtKB/Swiss-Prot:Q04810" /translation="MSSLKGKRIGFGLTGSHCTYEAVFPQIEELVNEGAEVRPVVTFN VKSTNTRFGEGAEWVKKIEDLTGYEAIDSIVKAEPLGPKLPLDCMVIAPLTGNSMSKL ANAMTDSPVLMAAKATIRNNRPVVLGISTNDALGLNGTNLMRLMSTKNIFFIPFGQDD PFKKPNSMVAKMDLLPQTIEKALMHQQLQPILVENYQGND*" /label="spoVFB CDS" gene 1619084..1619686 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /label="spoVFB gene" misc_feature 1619740..1619759 /Source="Nicolas_upshift_promotors" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1619740..1619811 /Source="Nicolas_S_feature" /locus_tag="new_1745919_1745990" /HighExp="S6, S7, S8, C90, S5, BT, MG 45, MG 5, SMM, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S599" upshifts 1619740 /Source="Nicolas_upshifts" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1619812..1620852 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /EC_number="1.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 12682299, 25355936, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 12682299, 25355936, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate-semialdehyde dehydrogenase" /protein_id="NP_389557.1" /db_xref="EnsemblGenomes-Gn:BSU16750" /db_xref="EnsemblGenomes-Tr:CAB13548" /db_xref="GOA:Q04797" /db_xref="InterPro:IPR000319" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR005986" /db_xref="InterPro:IPR012080" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10783" /db_xref="UniProtKB/Swiss-Prot:Q04797" /translation="MGRGLHVAVVGATGAVGQQMLKTLEDRNFEMDTLTLLSSKRSAG TKVTFKGQELTVQEASPESFEGVNIALFSAGGSVSQALAPEAVKRGAIVIDNTSAFRM DENTPLVVPEVNEADLHEHNGIIANPNCSTIQMVAALEPIRKAYGLNKVIVSTYQAVS GAGNEAVKELYSQTQAILNKEEIEPEIMPVKGDKKHYQIAFNAIPQIDKFQDNGYTFE EMKMINETKKIMHMPDLQVAATCVRLPIQTGHSESVYIEIDRDDATVEDIKNLLKEAP GVTLQDDPSQQLYPMPADAVGKNDVFVGRIRKDLDRANGFHLWVVSDNLLKGAAWNSV QIAESLKKLNLV*" /label="asd CDS" gene 1619812..1620852 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /label="asd gene" S_feature 1620853..1620943 /Source="Nicolas_S_feature" /locus_tag="new_1747032_1747122" /HighExp="S7, S6, S8, LBGtran, GM 120, dia15, Heat, LBGstat, GM 90, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S600" CDS 1620944..1622158 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1906928, 8098035" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906928, 8098035; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase I (alpha and beta subunits)" /protein_id="NP_389558.2" /db_xref="EnsemblGenomes-Gn:BSU16760" /db_xref="EnsemblGenomes-Tr:CAB13549" /db_xref="GOA:Q04795" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10784" /db_xref="UniProtKB/Swiss-Prot:Q04795" /translation="MKIIVQKFGGTSVKDDKGRKLALGHIKEAISEGYKVVVVVSAMG RKGDPYATDSLLGLLYGDQSAISPREQDLLLSCGETISSVVFTSMLLDNGVKAAALTG AQAGFLTNDQHTNAKIIEMKPERLFSVLANHDAVVVAGFQGATEKGDTTTIGRGGSDT SAAALGAAVDAEYIDIFTDVEGVMTADPRVVENAKPLPVVTYTEICNLAYQGAKVISP RAVEIAMQAKVPIRVRSTYSNDKGTLVTSHHSSKVGSDVFERLITGIAHVKDVTQFKV PAKIGQYNVQTEVFKAMANAGISVDFFNITPSEIVYTVAGNKTETAQRILMDMGYDPM VTRNCAKVSAVGAGIMGVPGVTSKIVSALSEKEIPILQSADSHTTIWVLVHEADMVPA VNALHEVFELSK*" /label="dapG CDS" gene 1620944..1622158 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /label="dapG gene" CDS 1622189..1623061 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /EC_number="4.3.3.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 9298659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 9298659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-tetrahydrodipicolinate synthase" /protein_id="NP_389559.1" /db_xref="EnsemblGenomes-Gn:BSU16770" /db_xref="EnsemblGenomes-Tr:CAB13550" /db_xref="GOA:Q04796" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR005263" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020624" /db_xref="InterPro:IPR020625" /db_xref="SubtiList:BG10785" /db_xref="UniProtKB/Swiss-Prot:Q04796" /translation="MNFGNVSTAMITPFDNKGNVDFQKLSTLIDYLLKNGTDSLVVAG TTGESPTLSTEEKIALFEYTVKEVNGRVPVIAGTGSNNTKDSIKLTKKAEEAGVDAVM LVTPYYNKPSQEGMYQHFKAIAAETSLPVMLYNVPGRTVASLAPETTIRLAADIPNVV AIKEASGDLEAITKIIAETPEDFYVYSGDDALTLPILSVGGRGVVSVASHIAGTDMQQ MIKNYTNGQTANAALIHQKLLPIMKELFKAPNPAPVKTALQLRGLDVGSVRLPLVPLT EDERLSLSSTISEL*" /label="dapA CDS" gene 1622189..1623061 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /label="dapA gene" S_feature complement(1622532..1623716) /Source="Nicolas_S_feature" /locus_tag="new_1748711_1749895_c" /HighExp="S8, S6, S4, S5, S7, S3, LoTm, T5.0H, BT, C30" /AntisenseName="dapA" /AntisenseCor="0.13444126275526899" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S601" downshifts 1623068 /Source="Nicolas_upshifts" /id="D905" /incds=0 /nref=17 /ntot=99 /MaxReadThrough="6.0497" /MaxDrop="5.05122" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1341" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1623161..1623164 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1623178 /Source="Nicolas_upshifts" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1623180..1623199 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1623239..1624906 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual activity 5' exo-and endoribonuclease J2" /protein_id="NP_389560.2" /db_xref="EnsemblGenomes-Gn:BSU16780" /db_xref="EnsemblGenomes-Tr:CAB13551" /db_xref="GOA:O31760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13422" /db_xref="UniProtKB/Swiss-Prot:O31760" /translation="MKKKNTENVRIIALGGVGEIGKNLYVIEIDSDIFVVDAGLMHPE NEMLGIDVVIPDISYLIERADRVKAIFLTHGHDENIGGVFYLLNKLSVPVYGTKLTLA LLREKLKQYGHNRKTDLREIHSKSVITFESTKVSFFRTIHSIPDSVGVSFKTSLGSIV CTGDFKFDQTPALNQTCDIGEIAKIGNSGVLALLSDSANAERPGYTPSEAAVSGEISD ALYNSQNRVIIAVFASNINRIQQVIHAAAQNGRKIAVAGKNLQSVLQLARKLGYIEAD DELFISVQDVKKYPKREVAIITAGSQGEPLAALTRMANKAHKQLNIEEGDTVVIASTP IPGQELIYSKTVDLLARAGAQVIFAQKRVHVSGHGSQEELKLMINLLKPKYLIPVNGE YRMQKAHSKIAEETGMKRSDIFLIEKGDVVEFRGQNVKIGDKVPYGNILIDGLGVGDI GNIVLRDRRLLSQDGILIVVITLDKQKKHLVSGPEIITRGFVYVRESEGLIVQATELV RSIVTEATETSNVEWSTLKQAMRDALNQFLYEKTKRKPMIIPIIMEV*" /label="rnjB CDS" gene 1623239..1624906 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /label="rnjB gene" promotor_-10 complement(1623703..1623721) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1623720) /Source="Nicolas_upshifts" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1623737..1623742) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1624894 /Source="Nicolas_upshifts" /id="D906" /incds=0 /nref=227 /ntot=263 /MaxReadThrough="4.0072" /MaxDrop="6.75416" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1624961..1624967 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-35" promotor_-10 1624981..1624992 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-10" upshifts 1624982 /Source="Nicolas_upshifts" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="upshifts" CDS 1625022..1625759 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10455123, 15189290, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455123, 15189290, 23927687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein export-enhancing protease (spore outgrowth)" /protein_id="NP_389561.3" /db_xref="EnsemblGenomes-Gn:BSU16790" /db_xref="EnsemblGenomes-Tr:CAB13552" /db_xref="GOA:Q99171" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11055" /db_xref="UniProtKB/Swiss-Prot:Q99171" /translation="MDHRMENTEEERPEKNDAKDSIMNKIQQLGETTLPQLPQDTNIH CLTIIGQIEGHVQLPPQNKTTKYEHVIPQIVAIEQNPKIEGLLIILNTVGGDVEAGLA IAEMLASLSKPTVSIVLGGGHSIGVPIAVSCDYSYIAETATMTIHPVRLTGLVIGVPQ TFEYLDKMQERVVKFVTSHSNITEEKFKELMFSKGNLTRDIGTNVVGKDAVKYGLIDH AGGVGQAINKLNELIDEARKEEGRMIQ*" /label="tepA CDS" gene 1625022..1625759 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /label="tepA gene" CDS 1625756..1625968 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23927687; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of TepA activity (spore outgrowth)" /protein_id="YP_003097729.1" /db_xref="EnsemblGenomes-Gn:BSU16799" /db_xref="EnsemblGenomes-Tr:CAX52620" /db_xref="InterPro:IPR025619" /db_xref="UniProtKB/Swiss-Prot:C0H413" /translation="MILYTVMPQEIVFAEQNQETSAHEQIEYKGVPLLVEMKGNEAEV IQIMSTNPMHFLHPDISPGQKLKLNV*" /label="tepJ CDS" gene 1625756..1625968 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /label="tepJ gene" misc_feature 1625996..1626015 /Source="Nicolas_upshift_promotors" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1626010 /Source="Nicolas_upshifts" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="upshifts" CDS 1626099..1628462 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11062134, 11778051, 12618465, 16430687, 17139259, 17322320, 18160039, 24297254, 24769697, 26452092; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore DNA directional translocase (motor ATPase)" /protein_id="NP_389562.3" /db_xref="EnsemblGenomes-Gn:BSU16800" /db_xref="EnsemblGenomes-Tr:CAB13553" /db_xref="GOA:P21458" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10763" /db_xref="UniProtKB/Swiss-Prot:P21458" /translation="MAKKKRKSRKKQAKQLNIKYELNGLLCIAISIIAILQLGVVGQT FIYLFRFFAGEWFILCLLGLLVLGVSLFWKKKTPSLLTRRKAGLYCIIASILLLSHVQ LFKNLTHKGSIESASVVRNTWELFLMDMNGSSASPDLGGGMIGALLFAASHFLFASTG SQIMAIVMILIGMILVTGRSLQETLKKWMSPIGRFIKEQWLAFIDDMKSFKSNMQSSK KTKAPSKKQKPARKKQQMEPEPPDEEGDYETVSPLIHSEPIISSFSDRNEEEESPVIE KRAEPVSKPLQDIQPETGDQETVSAPPMTFTELENKDYEMPSLDLLADPKHTGQQADK KNIYENARKLERTFQSFGVKAKVTQVHLGPAVTKYEVYPDVGVKVSKIVNLSDDLALA LAAKDIRIEAPIPGKSAIGIEVPNAEVAMVSLKEVLESKLNDRPDAKLLIGLGRNISG EAVLAELNKMPHLLVAGATGSGKSVCVNGIITSILMRAKPHEVKMMMIDPKMVELNVY NGIPHLLAPVVTDPKKASQALKKVVNEMERRYELFSHTGTRNIEGYNDYIKRANNEEG AKQPELPYIVVIVDELADLMMVASSDVEDSITRLSQMARAAGIHLIIATQRPSVDVIT GVIKANIPSRIAFSVSSQTDSRTILDMGGAEKLLGRGDMLFLPVGANKPVRVQGAFLS DDEVEKVVDHVITQQKAQYQEEMIPEETTETHSEVTDELYDEAVELIVGMQTASVSML QRRFRIGYTRAARLIDAMEERGVVGPYEGSKPREVLLSKEKYDELSS*" /label="spoIIIE CDS" gene 1626099..1628462 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /label="spoIIIE gene" S_feature 1628463..1628563 /Source="Nicolas_S_feature" /locus_tag="new_1754642_1754742" /HighExp="Cold, C30, G135, Lbstat, BC, G180, G150, S8, LoTm, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.109246" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S602" promotor_-35 1628524..1628531 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1628546..1628565 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1628564 /Source="Nicolas_upshifts" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="upshifts" CDS 1628606..1629331 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family,possibly involved in biofilm formation)" /protein_id="NP_389563.1" /db_xref="EnsemblGenomes-Gn:BSU16810" /db_xref="EnsemblGenomes-Tr:CAB13554" /db_xref="GOA:O31761" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13423" /db_xref="UniProtKB/Swiss-Prot:O31761" /translation="MSTKADNRHLYLKVIERIKEDIKNGIYTEKEKLPSEFELSKKLG VSRATLREALRILEEEHVIIRRHGVGTFVHSKPLFLSGIEQLNSVTKMIEQANMTPGT IFLSSQVLMPSEDDTKRFHLAEGQELFYLERVRTADGQPIVYCIDKIPMNILPNSFSH QQESMFDLLEKNSGSVISYAVTDIEPIGYHDTISPVLECDPETALLLLKQTHYDQHDK PVLYSLNYFRADKFRFHVLRKRF*" /label="ymfC CDS" gene 1628606..1629331 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /label="ymfC gene" downshifts 1629318 /Source="Nicolas_upshifts" /id="D907" /incds=0 /nref=135 /ntot=256 /MaxReadThrough="4.863" /MaxDrop="4.01593" /score="16.3235883" /energy="-7.2" /TU="U1346,U1347" /idTUdmin="U1346" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 1629387..1629393 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1629406 /Source="Nicolas_upshifts" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1629408..1629419 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1629470..1630678 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /function="7: Transport and binding proteins" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18502870, 27375568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18502870, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacillibactin exporter" /protein_id="NP_389564.2" /db_xref="EnsemblGenomes-Gn:BSU16825" /db_xref="EnsemblGenomes-Tr:CAB13555" /db_xref="GOA:O31762" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13424" /db_xref="UniProtKB/Swiss-Prot:O31762" /translation="MKNIIALSSVPLVMTLGNSMLIPVLPMMEKKLSVTSFQVSLIIT VYSVVAIICIPIAGYLSDRFGRKKILLPCLLIAGLGGAVAAFASTYMKNPYAMILAGR VLQGIGSAGAAPIVMPFIGDLFKGDDEKVSAGLGDIETANTSGKVLSPILGALLASWY WFVPFWFIPFFCLISFLLVLFLVAKPEEDEDAPAVSEFIKSVKKIFKQDGRWLYTVFI IGCVIMFLLFGVLFYLSDTLENKYAIDGVAKGGLLAIPLLFLSTSSFIAGKKIGKDKG RMKFCVVTGMILLTLSFIALWWNHSFYFLFVFLSFGGIGIGMALPALDALITEGIESE QCGTISSFYNSMRFIGVALGPPVFAALMSNANWIIFILSAFCSIVSLFLVLFTVDAKK SEEEKNLGTV*" /label="bcbE CDS" gene 1629470..1630678 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /label="bcbE gene" downshifts 1630636 /Source="Nicolas_upshifts" /id="D908" /incds=0 /nref=1 /ntot=32 /MaxReadThrough="1.34389" /MaxDrop="3.00655" /score="5.64651968" /energy="-6.7" /TU="NA" /idTUdmin="U1348" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1630747..1630754 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1630767..1630786 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1630789 /Source="Nicolas_upshifts" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" promotor_-35 1630801..1630804 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1630820..1630832 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1630834 /Source="Nicolas_upshifts" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1630858..1632138 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metalloprotease" /protein_id="NP_389566.2" /db_xref="EnsemblGenomes-Gn:BSU16845" /db_xref="EnsemblGenomes-Tr:CAB13557" /db_xref="GOA:O31764" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG13426" /db_xref="UniProtKB/Swiss-Prot:O31764" /translation="MSYVNELKSKHGGLTAHIVKTEKFKTVSLIFKMLAPLTKDQVTK RALLPHVLLRGTKSHPKTAGLRSYLDELYGTSVSADLTKKGERHVITFRLEIPNEKYL KDQTPLLEKGLQLLAELVFSPALEGDAFQSQYVAQEKRTLKQRIQAVYDDKMRYSNLR LIQEMCKNDPYALHVNGEIDDVDDITAEQLYETYQSAIQKDQLDLYVVGDVDSNQVQS AIDKYFKTEERTLGMIENNHADEKVQPKEVIDEEDVKQGKLNIGYRTSITYTDQDYPA LQVFNGLFGGFSHSKLFINVREKASLAYYAASRIESFKGLLMVMSGIEVKNFEQAVSI IAEQFQAMKNGDFSEQDIAQTKAVIRNQVLETIDTAYGLSEFLYQQAAAQVEIPIEDF LANIENVTKEDIIKAGEKIQLDTTYFLKGTEGAS*" /label="ymfF CDS" gene 1630858..1632138 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /label="ymfF gene" CDS 1632135..1633421 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative processing protease" /protein_id="NP_389568.2" /db_xref="EnsemblGenomes-Gn:BSU16860" /db_xref="EnsemblGenomes-Tr:CAB13559" /db_xref="GOA:O31766" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG13428" /db_xref="UniProtKB/Swiss-Prot:O31766" /translation="MIKPIEYEQLQETLYHEKMSNGLDVYVLPKKGFNKTYAVFTTKY GSIDNRFVPLGKNEMVHVPDGIAHFLEHKLFEKADGDVFQDFSKQGASANAFTSFTRT AYLFSSTSNVERNLETLIDFVQDPYFTEKTVEKEKGIIGQEINMYDDNPDWRLYFGVI ENMYKEHPVRIDIAGTVESISHITKDLLYECYETFYHPSNMLLFIVGPVDPEAIISQV RENQGKKPYTDQPEIKREEVKEQEAVFRKEKEIKMNVQGPKCLVGLKSKNPFKLGKEL LKHELSMNLLLEALFGKSSAQYESLYEKGYIDETFSFDFTAEYGFGFAAIGGDTPEPD QLAEDISSMLLRAGELITAEKIELARKKKIGTFLKALNSPEYIANQFTRYAFLDMSLF DVVTVLEQITLEDVQNVIQEEIAADRLTVCKVVPKS*" /label="ymfH CDS" gene 1632135..1633421 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /label="ymfH gene" downshifts 1633271 /Source="Nicolas_upshifts" /id="D909" /incds=1 /nref=10 /ntot=159 /MaxReadThrough="5.673" /MaxDrop="3.16735" /score="1.51160893" /energy="-10.4" /TU="U1349,U1350" /idTUdmin="U1350" /TUdmin="-1256" /isTUend="FALSE" /label="downshifts" S_feature 1633422..1633475 /Source="Nicolas_S_feature" /locus_tag="new_1759601_1759654" /HighExp="Etha, dia15, H2O2, G135, G150, G180, Paraq, LBGexp, Oxctl, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.431, 0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S603" CDS 1633476..1634204 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15066026, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 28787546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="EF-P-5 aminopentanone reductase (EF-P repair enzyme), NADPH-dependent" /protein_id="NP_389569.2" /db_xref="EnsemblGenomes-Gn:BSU16870" /db_xref="EnsemblGenomes-Tr:CAB13560" /db_xref="GOA:O31767" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13429" /db_xref="UniProtKB/Swiss-Prot:O31767" /translation="MNKTALITGASGGIGKSISETLAARGYNLLLHYNTNQNAAAELA EKLSQMFGVNAEILQADLSAQDGADKLTSSIVQPIDAIVLNSGRSHFGLITDVDNATV QEMVQLHVASPYMLTRNLLPGMIRNKSGAIVAVSSIWGETGASCEVLYSMAKGAQHSF VKGLAKELAPSGIRVNAVAPGAVDTNMMNQFTPAEKEEIADEIPIGRLARPQEIADAT AFLLSEKASYITGQILSVNGGWHC*" /label="efpI CDS" gene 1633476..1634204 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /label="efpI gene" promotor_-35 1634220..1634226 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1634238 /Source="Nicolas_upshifts" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1634240..1634251 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1634251) /Source="Nicolas_upshifts" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1634262..1634276) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1634285..1634289) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1634285..1634542 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389570.1" /db_xref="EnsemblGenomes-Gn:BSU16880" /db_xref="EnsemblGenomes-Tr:CAB13561" /db_xref="InterPro:IPR021637" /db_xref="InterPro:IPR024702" /db_xref="SubtiList:BG13430" /db_xref="UniProtKB/Swiss-Prot:O31768" /translation="MSVLENWDSWKNFLGDRLNYAQDKGMSQDTITDLATEIGSYLAN EVESKNEQEKVLADLWSVASKDEQHAIANMMVKLVENNSTH*" /label="ymfJ CDS" gene 1634285..1634542 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /label="ymfJ gene" downshifts 1634527 /Source="Nicolas_upshifts" /id="D910" /incds=0 /nref=165 /ntot=250 /MaxReadThrough="4.58488" /MaxDrop="7.23574" /score="21.9507801" /energy="-8.7" /TU="U1349,U1351" /idTUdmin="U1350" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1634559) /Source="Nicolas_upshifts" /id="D911" /incds=0 /nref=2 /ntot=15 /MaxReadThrough="3.44398" /MaxDrop="3.96475" /score="-6.33040789" /energy="-7.2" /TU="NA" /idTUdmin="U1344" /TUdmin="-11987" /isTUend="FALSE" /label="downshifts" promotor_-35 1634600..1634603 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1634618..1634637 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1634618 /Source="Nicolas_upshifts" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1634672..1635187 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; N-terminal part of YmfK" /db_xref="SubtiList:BG13431" /translation="MAKLEWYFEYEIQVNRPGLLGDISSLLGMLSINIVTINGVDLSR RGMLLRCRHIDQIKRLESILKTMETIKVTKLREPRLRDRLAVRHGRYIQRDADDKKTF RFERDELGLLVDFMAELFKKEGHKLIGIRGMPRVGKTESIVASSVCEQKVAVCVINLA EADDKKPADCR*" /label="ymfKn CDS" gene 1634672..1635187 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /pseudo /label="ymfKn gene" CDS 1635123..1635461 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; C-terminal part of YmfK" /db_xref="SubtiList:BG13432" /translation="RWLFVSSTLLKQTIRSQLIADEYSTENVFIVDGIVSTRRGSERH LQLVREIMRLPATKVVEHPDIFVQNTEYTLDDFDYIIELRNDPDEVITYEHAEEPQMF DQSGFSSFDF*" /label="ymfKc CDS" gene 1635123..1635461 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /pseudo /label="ymfKc gene" CDS 1635528..1636394 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 19164570, 22720735, 23879732, 27415800, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 19164570, 22720735, 23879732, 27415800, 27818647; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell shape determination factor" /protein_id="NP_389573.3" /db_xref="EnsemblGenomes-Gn:BSU16910" /db_xref="EnsemblGenomes-Tr:CAB13564" /db_xref="GOA:O31771" /db_xref="InterPro:IPR025194" /db_xref="SubtiList:BG13433" /db_xref="UniProtKB/Swiss-Prot:O31771" /translation="MSLDDLQAATKIQKRYLTALEEGNYDIIPGKFYVRAFIKQYAEA VGLDADQLFEEHKKDIPNTYHDDVSEKISGMNLQKEMPKPASKALELLPTILVILGVI VVIAIVYAIIQFANHKNSDDHNAASEKAITQSESKYEIPKDSTLKENQNNSSEKETDT KKETKENEDKKKENDSEKLEIKAAGTEGSLTTYEVSGADKIELELKASDSSWIRVRDE NSSSLKEGTLKKDETYKKDITDQKQVDIRTGYAPNLKIKINGKVLSYELDPKKVMAQT IKIVNKKEEKSS*" /label="rodZ CDS" gene 1635528..1636394 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /label="rodZ gene" promotor_no_box 1635591..1635691 /Source="Nicolas_upshift_promotors" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_no_box" upshifts 1635651 /Source="Nicolas_upshifts" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" downshifts 1636354 /Source="Nicolas_upshifts" /id="D912" /incds=0 /nref=1 /ntot=107 /MaxReadThrough="5.43253" /MaxDrop="2.8328" /score="21.9507801" /energy="-8.7" /TU="U1353,U1354" /idTUdmin="U1351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1636444..1637025 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /EC_number="2.7.8.5" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15743965, 15849754, 16514141, 16850406, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15743965, 15849754, 16514141, 16850406, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase" /protein_id="NP_389574.2" /db_xref="EnsemblGenomes-Gn:BSU16920" /db_xref="EnsemblGenomes-Tr:CAB13565" /db_xref="GOA:P46322" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004570" /db_xref="SubtiList:BG11373" /db_xref="UniProtKB/Swiss-Prot:P46322" /translation="MFNLPNKITLARIALIPIFMIIMLAPFDWGRLEVGDESIPVAHL AGAILFIIASTTDWVDGYYARKLNLVTNFGKFLDPLADKLLVSAALIILVQFDLAPAW MVIVIISREFAVTGLRLVLAGTGEVVAANMLGKIKTWAQIIAVSALLLHNLPFELVSF PFADLALWVAVFFTVVSGWEYFSKNWEALKTSN*" /label="pgsA CDS" gene 1636444..1637025 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /label="pgsA gene" CDS 1637043..1638293 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438773, 11703670, 20480359; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence-damage inducible regulator" /protein_id="NP_389575.2" /db_xref="EnsemblGenomes-Gn:BSU16930" /db_xref="EnsemblGenomes-Tr:CAB13566" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008135" /db_xref="InterPro:IPR008136" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036653" /db_xref="SubtiList:BG11374" /db_xref="UniProtKB/Swiss-Prot:P46323" /translation="MEFPKKAEIIAVGSELLLGQIANTNAQFISKQLAEIGVNVFYHT AVGDNPERLKQVIRIAEERSDFIIFSGGLGPTKDDLTKETIANTLGRPLVLNDEAFQS IEDYFKRTKRTMSPNNRKQALVIEGSDVLANHFGMAPGMLTEHESRYYMLLPGPPSEL RPMFENEAKPLLLKKMGSNEKIVSTVLRFFGIGESQLEADLEDIIDAQTNPTIAPLAA DGEVTLRLTAKHADEKETERLLKETEAVILERVGEFFYGYDDTSLVKELSIACKEKGI TISAAESFTGGLFSEWLTDHSGASKLFAGGVVCYTNDVKQNVLGVKKETLDRFGAVSK ECASELAKGVQKLTGSDIGISFTGVAGPDAQEGHEPGHVFIGISANGKEEVHEFHFAG SRTGIRKRGAKYGCHLILKLLEQK*" /label="cinA CDS" gene 1637043..1638293 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /label="cinA gene" S_feature 1638294..1638420 /Source="Nicolas_S_feature" /locus_tag="new_1764473_1764599" /HighExp="LBGstat, LBGtran, G135, Lbstat, G150, C30, LBGexp, dia0, S0, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.016, 0.998" /TUlongSig="SigA" /TUlongPSig="0.987" /label="S604" promotor_-35 1638400..1638407 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1638422..1638441 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1638422 /Source="Nicolas_upshifts" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1638466..1639512 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191; Product type f: factor" /codon_start=1 /transl_table=11 /product="multifunctional SOS repair factor" /protein_id="NP_389576.2" /db_xref="EnsemblGenomes-Gn:BSU16940" /db_xref="EnsemblGenomes-Tr:CAB13567" /db_xref="GOA:P16971" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013765" /db_xref="InterPro:IPR020584" /db_xref="InterPro:IPR020587" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR023400" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10721" /db_xref="UniProtKB/Swiss-Prot:P16971" /translation="MSDRQAALDMALKQIEKQFGKGSIMKLGEKTDTRISTVPSGSLA LDTALGIGGYPRGRIIEVYGPESSGKTTVALHAIAEVQQQGGQAAFIDAEHALDPVYA QKLGVNIEELLLSQPDTGEQALEIAEALVRSGAVDIVVVDSVAALVPKAEIEGDMGDS HVGLQARLMSQALRKLSGAINKSKTIAIFINQIREKVGVMFGNPETTPGGRALKFYSS VRLEVRRAEQLKQGNDVMGNKTKIKVVKNKVAPPFRTAEVDIMYGEGISKEGEIIDLG TELDIVQKSGSWYSYEEERLGQGRENAKQFLKENKDIMLMIQEQIREHYGLDNNGVVQ QQAEETQEELEFEE*" /label="recA CDS" gene 1638466..1639512 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /label="recA gene" downshifts 1639524 /Source="Nicolas_upshifts" /id="D913" /incds=0 /nref=201 /ntot=262 /MaxReadThrough="4.54659" /MaxDrop="9.405" /score="23.91264" /energy="-9.7" /TU="U1355" /idTUdmin="U1353" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 1639569..1639634 /Source="Nicolas_S_feature" /locus_tag="new_1765748_1765813" /HighExp="S7, S5, S8, S4, H2O2, C30, T5.0H, S6, ferm, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="Sig-, SigA, SigA" /TUlongPSig="0.016, 0.998, 0.987" /label="S605" promotor_-35 1639606..1639615 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1639628..1639643 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1639636 /Source="Nicolas_upshifts" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1639680..1640855 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14762009, 15758244, 21856855" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762009, 15758244, 21856855; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding endopeptidase X (lysozyme resistance)" /protein_id="NP_389577.1" /db_xref="EnsemblGenomes-Gn:BSU16950" /db_xref="EnsemblGenomes-Tr:CAB13568" /db_xref="GOA:O31773" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="SubtiList:BG12642" /db_xref="UniProtKB/Swiss-Prot:O31773" /translation="MTSPTRRRTAKRRRRKLNKRGKLLFGLLAVMVCITIWNALHRNS EENEPSQETAAVSNTDQKKEVKKKTAKKSEEQIKTVDRNQKISNYLKEIGFSGTAMIV RNGEIVTNKGFGYADRKHYIQNNPLTSFYVGSSQKALIATAILQLEEKGKLQTSDPVS TYLPHFPNGQTITLKNLLTHTSGINGHIEGNGAITPDDLIKDIELQGIKRQPGVWDYK DSNYSVLAYIIAEVSGEPYEQYIKNHIFKPAGMTHAGFYKTYEKEPYPAVGYKMEGSK TVTPYIPDLSQLYGAGDIYMSAIDMYKFDQALIDGKLYSQKSYEKMFTPGSSSTYGMG FYVAPGSYSNHGVMPGFNILNSFSKSGQTIVILFSNIQNNAKLGQVNNKIYQLLNQE* " /label="pbpX CDS" gene 1639680..1640855 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /label="pbpX gene" S_feature 1640856..1640955 /Source="Nicolas_S_feature" /locus_tag="new_1767035_1767134" /HighExp="dia0, LBGexp, Lbexp, Oxctl, Paraq, H2O2, C30, G150, Mt0, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.54369999999999996" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA, Sig-, SigA, SigA" /TUlongPSig="1, 0.016, 0.998, 0.987" /label="S606" promotor_-35 1640929..1640936 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1640950..1640969 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" S_feature 1640957..1641130 /Source="Nicolas_S_feature" /locus_tag="new_1767136_1767309" /HighExp="M9-stat, T3.30H, BC, T2.0H, T3.0H, T-1.40H, T1.30H, T2.30H, T4.0H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S607" upshifts 1640957 /Source="Nicolas_upshifts" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1641131..1642693 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /EC_number="3.1.26.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease Y" /protein_id="NP_389578.1" /db_xref="EnsemblGenomes-Gn:BSU16960" /db_xref="EnsemblGenomes-Tr:CAB13569" /db_xref="GOA:O31774" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR017705" /db_xref="InterPro:IPR022711" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG13420" /db_xref="UniProtKB/Swiss-Prot:O31774" /translation="MTPIMMVLISILLILLGLVVGYFVRKTIAEAKIAGARGAAEQIL EDAKRDAEALKKEALLEAKDEIHKLRIDAEQEVRERRNELQKQENRLLQKEENLDRKH EGIDKREAMLEKKDHSLNERQQHIEEMESKVDEMIRMQQSELERISSLTRDEAKQIIL ERVENELSHDIAIMTKETENRAKEEADKKAKNILSLALQRCAADHVAETTVSVVNLPN DEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRRETARIALDKLVQD GRIHPARIEEMVEKSRREVDDYIREMGEQTTFEVGVHGLHPDLIKILGRLKFRTSYGQ NVLKHSMEVAFLAGLMASELGEDAKLAKRAGLLHDIGKAIDHEVEGSHVEIGVELATK YKEHPVVINSIASHHGDEEPTSIIAVLVAAADALSAARPGARSETLENYIRRLEKLEE ISESYEGVEKSFAIQAGREVRIMVKPDSINDLEAHRLARDIRKRIEDELDYPGHIKVT VIRETRAVEYAK*" /label="rny CDS" gene 1641131..1642693 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /label="rny gene" downshifts 1642670 /Source="Nicolas_upshifts" /id="D914" /incds=0 /nref=243 /ntot=268 /MaxReadThrough="5.32126" /MaxDrop="5.3789" /score="10.4712371" /energy="-9" /TU="U1357" /idTUdmin="U1357" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" CDS 1642762..1643556 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19376879, 21856853, 24163345, 26904951, 26906740" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19376879, 21856853, 24163345, 26904951, 26906740; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2'3' and 3'5' cyclic nucleotide monophosphates phosphodiesterase involved in biofilm formation" /protein_id="NP_389579.2" /db_xref="EnsemblGenomes-Gn:BSU16970" /db_xref="EnsemblGenomes-Tr:CAB13570" /db_xref="GOA:O31775" /db_xref="InterPro:IPR005235" /db_xref="InterPro:IPR029052" /db_xref="PDB:4B2O" /db_xref="SubtiList:BG13421" /db_xref="UniProtKB/Swiss-Prot:O31775" /translation="MRILFIGDVVGSPGRDMVKEYVPKLKTKYKPHFTIINGENAAHG KGLTEKIYHSLIQSGADAITMGNHTWDKKEIFDFIDDVPNLVRPANFPEGTPGKGITY VKANGKELAVINLQGRTFLPPLDDPFLKADELIAEAAKRTPYIFIDFHAEATSEKLAL GWYTDGRASAVVGTHTHVQTADNRILPKGTAYITDVGMTGPYDGILGMDRETIIKRFK TNLPVRFTVAEGKTTLSGVVIDIDDQTKKAVKIERILINDDHMFFE*" /label="pdeB CDS" gene 1642762..1643556 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /label="pdeB gene" promotor_-35 1643311..1643316 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1643332..1643350 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1643352 /Source="Nicolas_upshifts" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="upshifts" promotor_-35 1643600..1643605 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-35" S_feature 1643616..1643755 /Source="Nicolas_S_feature" /locus_tag="new_1769795_1769934" /HighExp="T5.0H, LoTm, BT, B60, S8, M9-stat, S6, BC, B36, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="0.916, 0.91, 1" /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S608" upshifts 1643616 /Source="Nicolas_upshifts" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="upshifts" promotor_-10 1643621..1643639 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-10" upshifts complement(1643648) /Source="Nicolas_upshifts" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1643659..1643672) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1643681..1643685) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1643692) /Source="Nicolas_upshifts" /id="D915" /incds=0 /nref=5 /ntot=35 /MaxReadThrough="1.51152" /MaxDrop="3.63977" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=10274 /isTUend="FALSE" /label="downshifts" CDS 1643756..1644016 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7559352, 16428420, 18562273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559352, 16428420, 18562273; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for dehydratation of the spore core and assembly of the coat (stage V sporulation)" /protein_id="NP_389580.1" /db_xref="EnsemblGenomes-Gn:BSU16980" /db_xref="EnsemblGenomes-Tr:CAB13571" /db_xref="GOA:P45693" /db_xref="InterPro:IPR007347" /db_xref="SubtiList:BG11245" /db_xref="UniProtKB/Swiss-Prot:P45693" /translation="MEILKVSAKSSPNSVAGALAGVLRERGAAEIQAIGAGALNQAVK AVAIARGFVAPSGVDLICIPAFTDIQIDGEERTAIKLIVEPR*" /label="spoVS CDS" gene 1643756..1644016 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /label="spoVS gene" downshifts 1643968 /Source="Nicolas_upshifts" /id="D916" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="8.31914" /MaxDrop="4.27515" /score="5.18548432" /energy="-12.5" /TU="U1357,U1358,U1359" /idTUdmin="U1357" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts complement(1644000) /Source="Nicolas_upshifts" /id="D917" /incds=0 /nref=3 /ntot=15 /MaxReadThrough="1.16149" /MaxDrop="3.88837" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=9966 /isTUend="FALSE" /label="downshifts" downshifts 1644012 /Source="Nicolas_upshifts" /id="D918" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.08266" /MaxDrop="5.124" /score="5.18548432" /energy="-12.5" /TU="U1358,U1359" /idTUdmin="U1357" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1644057..1644231 /Source="Nicolas_S_feature" /locus_tag="new_1770236_1770410" /HighExp="S6, S8, S7, M9-stat, Lbstat, BT, S5, T1.30H, T2.0H, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.916, 0.91" /TUlongSig="SigA, SigWXY" /TUlongPSig="1, 1" /label="S609" promotor_-35 1644215..1644222 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1644233 /Source="Nicolas_upshifts" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1644237..1644256 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1644282..1645325 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /EC_number="1.1.1.103" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8519804, 16817900, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine 3-dehydrogenase" /protein_id="NP_389581.1" /db_xref="EnsemblGenomes-Gn:BSU16990" /db_xref="EnsemblGenomes-Tr:CAB13572" /db_xref="GOA:O31776" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR004627" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12685" /db_xref="UniProtKB/Swiss-Prot:O31776" /translation="MQSGKMKALMKKDGAFGAVLTEVPIPEIDKHEVLIKVKAASICG TDVHIYNWDQWARQRIKTPYVFGHEFSGIVEGVGENVSSVKVGEYVSAETHIVCGECV PCLTGKSHVCTNTAIIGVDTAGCFAEYVKVPADNIWRNPADMDPSIASIQEPLGNAVH TVLESQPAGGTTAVIGCGPIGLMAVAVAKAAGASQVIAIDKNEYRLRLAKQMGATCTV SIEKEDPLKIVSALTSGEGADLVCEMSGHPSAIAQGLAMAANGGRFHILSLPEHPVTI DLTNKVVFKGLTIQGITGRKMFSTWRQVSQLISSNMIDLAPVITHQFPLEEFEKGFEL MRSGQCGKVILIP*" /label="tdh CDS" gene 1644282..1645325 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /label="tdh gene" CDS 1645338..1646516 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /EC_number="2.3.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17146529, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-amino-3-ketobutyrate CoA ligase (glycine acetyl transferase)" /protein_id="NP_389582.1" /db_xref="EnsemblGenomes-Gn:BSU17000" /db_xref="EnsemblGenomes-Tr:CAB13573" /db_xref="GOA:O31777" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR010962" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12610" /db_xref="UniProtKB/Swiss-Prot:O31777" /translation="MTKEFEFLKAELNSMKENHTWQDIKQLESMQGPSVTVNHQKVIQ LSSNNYLGFTSHPRLINAAQEAVQQYGAGTGSVRTIAGTFTMHQELEKKLAAFKKTEA ALVFQSGFTTNQGVLSSILSKEDIVISDELNHASIIDGIRLTKADKKVYQHVNMSDLE RVLRKSMNYRMRLIVTDGVFSMDGNIAPLPDIVELAEKYDAFVMVDDAHASGVLGENG RGTVNHFGLDGRVHIQVGTLSKAIGVLGGYAAGSKVLIDYLRHKGRPFLFSTSHPPAV TAACMEAIDVLLEEPEHMERLWENTAYFKAMLVKMGLTLTKSETPILPILIGDEGVAK QFSDQLLSRGVFAQSIVFPTVAKGKARIRTIITAEHTKDELDQALDVIEKTAKELQLL *" /label="kbl CDS" gene 1645338..1646516 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /label="kbl gene" downshifts 1646498 /Source="Nicolas_upshifts" /id="D919" /incds=0 /nref=3 /ntot=25 /MaxReadThrough="5.75732" /MaxDrop="3.4918" /score="4.73069387" /energy="-12.5" /TU="U1361" /idTUdmin="U1359" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" promotor_-35 1646596..1646599 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1646608 /Source="Nicolas_upshifts" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1646614..1646633 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1646664..1648193 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /EC_number="2.8.4.3" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15175311, 18307109, 20472640, 20584901, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 18307109, 20472640, 20584901, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme for ms(2)i(6)A formation for tRNA modification" /protein_id="NP_389583.1" /db_xref="EnsemblGenomes-Gn:BSU17010" /db_xref="EnsemblGenomes-Tr:CAB13574" /db_xref="GOA:O31778" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006463" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="SubtiList:BG13418" /db_xref="UniProtKB/Swiss-Prot:O31778" /translation="MNEKQKLESGQVHPSDKKSEKDYSKYFEAVYIPPSLKDAKKRGK EAVTYHNDFKISEQFKGLGDGRKFYIRTYGCQMNEHDTEVMAGIFMALGYEATNSVDD ANVILLNTCAIRENAENKVFGELGHLKALKKNNPDLILGVCGCMSQEESVVNRILKKH PFVDMIFGTHNIHRLPELLSEAYLSKEMVVEVWSKEGDVIENLPKVRNGKIKGWVNIM YGCDKFCTYCIVPYTRGKERSRRPEDIIQEVRRLASEGYKEITLLGQNVNAYGKDFED MTYGLGDLMDELRKIDIPRIRFTTSHPRDFDDRLIEVLAKGGNLLDHIHLPVQSGSSE VLKLMARKYDRERYMELVRKIKEAMPNASLTTDIIVGFPNETDEQFEETLSLYREVEF DSAYTFIYSPREGTPAAKMKDNVPMRVKKERLQRLNALVNEISAKKMKEYEGKVVEVL VEGESKNNPDILAGYTEKSKLVNFKGPKEAIGKIVRVKIQQAKTWSLDGEMVGEAIEV K*" /label="miaB CDS" gene 1646664..1648193 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /label="miaB gene" CDS 1648195..1648626 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator for biofilm formation via regulation of RNase Y (RicAFT complex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389584.1" /db_xref="EnsemblGenomes-Gn:BSU17020" /db_xref="EnsemblGenomes-Tr:CAB13575" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR016783" /db_xref="InterPro:IPR023378" /db_xref="PDB:2PIH" /db_xref="SubtiList:BG13417" /db_xref="UniProtKB/Swiss-Prot:O31779" /translation="MTLYSKKDIVQQARNLAKMISETEEVDFFKRAEAQINENDKVST IVNQIKALQKQAVNLKHYEKHEALKQVEAKIDALQEELEEIPVIQEFRDSQMEVNDLL QLVAHTISNQVTNEIITSTGGDLLKGETGSKVKHSNNSCSL*" /label="ricA CDS" gene 1648195..1648626 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /label="ricA gene" downshifts 1648609 /Source="Nicolas_upshifts" /id="D920" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="0.9572" /MaxDrop="7.73043" /score="21.1260722" /energy="-10.3" /TU="NA" /idTUdmin="U1361" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1648757..1648762 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1648778..1648796 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1648786..1648887 /Source="Nicolas_S_feature" /locus_tag="new_1774965_1775066" /HighExp="S3, S5, S8, S4, S6, S7, B36, BT, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S610" upshifts 1648786 /Source="Nicolas_upshifts" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="upshifts" CDS 1648888..1649433 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenic spore protein" /protein_id="NP_389585.1" /db_xref="EnsemblGenomes-Gn:BSU17030" /db_xref="EnsemblGenomes-Tr:CAB13576" /db_xref="GOA:P14016" /db_xref="InterPro:IPR018901" /db_xref="SubtiList:BG10494" /db_xref="UniProtKB/Swiss-Prot:P14016" /translation="MSEYREIITKAVVAKGRKFTQCTNTISPEKKPSSILGGWIINHK YDAEKIGKTVEIEGYYDINVWYSYADNTKTEVVTERVKYVDVIKLRYRDNNYLDDEHE VIAKVLQQPNCLEVTISPNGNKIVVQAEREFLAEVVGETKVVVEVNPDWEEDDEEDWE DELDEELEDINPEFLVGDPEE*" /label="cotE CDS" gene 1648888..1649433 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /label="cotE gene" downshifts 1649427 /Source="Nicolas_upshifts" /id="D921" /incds=0 /nref=64 /ntot=97 /MaxReadThrough="4.37388" /MaxDrop="8.23792" /score="10.7927556" /energy="-12.6" /TU="U1363" /idTUdmin="U1363" /TUdmin="-745" /isTUend="FALSE" /label="downshifts" downshifts complement(1649434) /Source="Nicolas_upshifts" /id="D922" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="4.21458" /MaxDrop="3.44208" /score="12.3953461" /energy="-11.4" /TU="NA" /idTUdmin="U1366" /TUdmin=4532 /isTUend="FALSE" /label="downshifts" promotor_-35 1649491..1649494 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1649509..1649528 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1649513 /Source="Nicolas_upshifts" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="upshifts" CDS 1649566..1652142 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /function="16.5: Explore" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15375129, 16269814, 23998896, 26343983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 16269814, 23998896, 26343983; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA mismatch repair recognition factor" /protein_id="NP_389586.2" /db_xref="EnsemblGenomes-Gn:BSU17040" /db_xref="EnsemblGenomes-Tr:CAB13577" /db_xref="GOA:P49849" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR005748" /db_xref="InterPro:IPR007695" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR007860" /db_xref="InterPro:IPR007861" /db_xref="InterPro:IPR016151" /db_xref="InterPro:IPR017261" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036187" /db_xref="InterPro:IPR036678" /db_xref="SubtiList:BG11403" /db_xref="UniProtKB/Swiss-Prot:P49849" /translation="MAGYTPMIQQYLKIKAEHQDAFLFFRLGDFYEMFFEDAKKASQE LEITLTSRDGGAAEKIPMCGVPYHSASAYIEQLIKKGYKVAICEQTEDPKAAKGVVKR EVVQLITPGTVMDGKGIHESENNFIASVSACSNGYGLALSDLTTGENLAVLIERLEDV ISEIYSVGAREIVVSGSLDADTVAQLRERCGATISIEDGETDEHVTIIEHLNNEDITK TFLRLYTYLKRTQKRSLDHLQPVQVYELEEAMKIDLYSKRNLELTETIRSKNKKGSLL WLLDETKTAMGGRLLKQWIDRPLIRVNQIEERQEMVETLMSHFFEREDLRERLKEVYD LERLAGRVAFGNVNARDLIQLKESLKQVPGIKQLVASLAHDKAKERAKRIDPCGDVLE LLEEALYENPPLSVKEGNLIKDGYNQKLDEYRDASRNGKDWIARLEQQEREYTGIRSL KVGFNKVFGYYIEVTKANLHLLEEGRYERKQTLTNAERYITPELKEKEALILEAENNI CELEYELFTELREKVKQYIPRLQQLAKQMSELDALQCFATISENRHYTKPEFSKDEVE VIEGRHPVVEKVMDSQEYVPNNCMMGDNRQMLLITGPNMSGKSTYMRQIALISIMAQI GCFVPAKKAVLPIFDQIFTRIGAADDLISGQSTFMVEMLEAKNAIVNATKNSLILFDE IGRGTSTYDGMALAQAIIEYVHDHIGAKTLFSTHYHELTVLEDKLPQLKNVHVRAEEY NGTVVFLHQIKEGAADKSYGIHVAQLAELPGDLIARAQDILKELEHSGNKPEVPVQKP QVKEEPAQLSFFDEAEKPAETPKLSKKEKQVIDAFKSLNILDMTPLEAMNEMYKLQKK LH*" /label="mutS CDS" gene 1649566..1652142 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /label="mutS gene" CDS 1652158..1654041 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15375129, 22843852, 26343983, 26384423, 27369079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 22843852, 26343983, 26384423, 27369079; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA mismatch repair endonuclease" /protein_id="NP_389587.1" /db_xref="EnsemblGenomes-Gn:BSU17050" /db_xref="EnsemblGenomes-Tr:CAB13578" /db_xref="GOA:P49850" /db_xref="InterPro:IPR002099" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR013507" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR014762" /db_xref="InterPro:IPR014790" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020667" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037198" /db_xref="PDB:3GAB" /db_xref="PDB:3KDG" /db_xref="PDB:3KDK" /db_xref="SubtiList:BG11402" /db_xref="UniProtKB/Swiss-Prot:P49850" /translation="MAKVIQLSDELSNKIAAGEVVERPASVVKELVENAIDADSTVIE IDIEEAGLASIRVLDNGEGMENEDCKRAFRRHATSKIKDENDLFRVRTLGFRGEALPS IASVSHLEITTSTGEGAGTKLVLQGGNIISESRSSSRKGTEIVVSNLFFNTPARLKYM KTVHTELGNITDVVNRIALAHPEVSIRLRHHGKNLLQTNGNGDVRHVLAAIYGTAVAK KMLPLHVSSLDFEVKGYIALPEITRASRNYMSSVVNGRYIKNFPLVKAVHEGYHTLLP IGRHPITFIEITMDPILVDVNVHPSKLEVRLSKETELHDLIRDGIKDVFKQQQLIPSA QVPKKSAPAIKNEQQFITFDEKPPEKKVPEKSTAPSYSPMKLSSVVKEPVDAEEKLPP LQFDAPPIVDQEQTLEVSDVSAEQPETFEQECHEEQPQPASDRVPIMYPIGQMHGTYI LAQNENGLYIIDQHAAQERIKYEYFREKVGEVEPEVQEMIVPLTFHYSTNEALIIEQH KQELESVGVFLESFGSNSYIVRCHPAWFPKGEEAELIEEIIQQVLDSKNIDIKKLREE AAIMMSCKGSIKANRHLRNDEIKALLDDLRSTSDPFTCPHGRPIIIHHSTYEMEKMFK RVM*" /label="mutL CDS" gene 1652158..1654041 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /label="mutL gene" S_feature complement(1653944..1654438) /Source="Nicolas_S_feature" /locus_tag="new_1780123_1780617_c" /HighExp="M9-stat, LBGstat, LPhT, T2.0H, Lbstat, C30, T2.30H, M0t90, T1.30H, HiOs" /AntisenseName="mutL" /AntisenseCor="0.27126904061692803" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S611" downshifts 1653956 /Source="Nicolas_upshifts" /id="D923" /incds=1 /nref=216 /ntot=257 /MaxReadThrough="2.0064" /MaxDrop="5.37369" /score="33.4967163" /energy="-18.6" /TU="NA" /idTUdmin="U1364" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1653966) /Source="Nicolas_upshifts" /id="D924" /incds=1 /nref=3 /ntot=100 /MaxReadThrough="1.93338" /MaxDrop="2.7192" /score="27.1353816" /energy="-13.5" /TU="NA" /idTUdmin="U1366" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1654188..1654195 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1654210..1654229 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1654220..1654353 /Source="Nicolas_S_feature" /locus_tag="new_1780399_1780532" /HighExp="LoTm, T0.30H, T1.30H, M9-stat, T3.0H, BC, T1.0H, B60, B36, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99494800000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S612" upshifts 1654220 /Source="Nicolas_upshifts" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1654225..1654375) /gene="surX" /locus_tag="BSU_misc_RNA_89" /product="small untranslated RNA of unknown function" /note="Evidence 5: Unknown function; PubMedId : 20525796, 23155385" /label="surX RNA" gene complement(1654225..1654375) /gene="surX" /locus_tag="BSU_misc_RNA_89" /label="surX gene" downshifts 1654310 /Source="Nicolas_upshifts" /id="D925" /incds=0 /nref=19 /ntot=136 /MaxReadThrough="3.45962" /MaxDrop="4.12444" /score="29.4045648" /energy="-15.3" /TU="U1365" /idTUdmin="U1364" /TUdmin=354 /isTUend="FALSE" /label="downshifts" CDS complement(1654439..1654894) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="YP_054578.1" /db_xref="EnsemblGenomes-Gn:BSU17060" /db_xref="EnsemblGenomes-Tr:CAE01453" /db_xref="GOA:Q7WY71" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14188" /db_xref="UniProtKB/Swiss-Prot:Q7WY71" /translation="MNQKEQNEHSKDFNLRSKLIGIVSITFIAAIALAVIFGGFFFGM KGLFSILGITYASNQTLALFILACFAVGLIIDPLTKIISIILAKSLSLKKTALFAFIL YFISNLITICFADYFMQSIYIPDVLLVVISAFMAIIELAFDNQPNREAA*" /label="ymzD CDS" gene complement(1654439..1654894) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /label="ymzD gene" S_feature complement(1654895..1654986) /Source="Nicolas_S_feature" /locus_tag="new_1781074_1781165_c" /HighExp="LBGstat, M9-stat, T1.0H, T1.30H, T2.0H, M0t90, MG 150, LPhT, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S613" promotor_-10 complement(1654974..1654993) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1654986) /Source="Nicolas_upshifts" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1655010..1655013) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1655049..1655606) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389588.1" /db_xref="EnsemblGenomes-Gn:BSU17070" /db_xref="EnsemblGenomes-Tr:CAB13579" /db_xref="GOA:O31780" /db_xref="SubtiList:BG13419" /db_xref="UniProtKB/Swiss-Prot:O31780" /translation="MNGIAWMIVFCEIAFWVVIVLGLAVRYVFKRHTLGLLFLALTPV IDLILLAATGVDLYRGASATAAHGIAAVYIGISIAYGKQMIQWADEKFQYYVTKKGTK PLKRFGMDHAKHGAKGWLRHVLAYLIGAGLLAGMIYFINDSSRTEALSGILKLWTVII GIDFLITASYFIWPKKEKASANLRS*" /label="ymcC CDS" gene complement(1655049..1655606) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /label="ymcC gene" SCAR 1655697..1655698 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs08" downshifts complement(1655749) /Source="Nicolas_upshifts" /id="D929" /incds=0 /nref=24 /ntot=184 /MaxReadThrough="3.69744" /MaxDrop="5.18486" /score="-0.71313204" /energy="-20.1" /TU="U1374" /idTUdmin="U1375" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(1655755..1656111) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11544224, 15805528, 20817675" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function involved in ethanol resistance" /protein_id="NP_389606.3" /db_xref="EnsemblGenomes-Gn:BSU17240" /db_xref="EnsemblGenomes-Tr:CAB13608" /db_xref="SubtiList:BG13435" /db_xref="UniProtKB/Swiss-Prot:O31786" /translation="MAHTNTQLSQWLESKVGQTLDIRKGELTHDEEISDLDQIVLHLQ KVAIRSTNHPDDYVAKEELVLEGEGTTFTEDGNVPLPQNAYEIPLLGELHIHQENEGL KVVTDRAVYTIDIQHS*" /label="ymzB CDS" gene complement(1655755..1656111) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /label="ymzB gene" misc_feature complement(1656171..1656184) /Source="Nicolas_upshift_promotors" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1656176) /Source="Nicolas_upshifts" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1656190..1657014) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20817675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389607.2" /db_xref="EnsemblGenomes-Gn:BSU17250" /db_xref="EnsemblGenomes-Tr:CAB13609" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13413" /db_xref="UniProtKB/Swiss-Prot:O31787" /translation="MPYYICNTCGVQHAQTVDPPNSCLICEDERQYIHPDGQTWTTLE DMREKGNLQNILKKEEEHLYSIKTEPEFAIGQTAHLIQHKGFNVLWDCMTYLDQKTID QINELGGIQAIALSHPHYYSTQVEWAEAFQAPIYIHEDDKEWVTRPSNHIHFWSGETL NMKPGLDLYRLGGHFKGGAVLHWSKGNEGKGCLLTGDIITVAADRNWVSFMYSYPNLI PLPASKVEEIAAKVKPLQFNRLYNAFSKVVKENADESVQRSAVRYIKALNSELFHT*" /label="ymaE CDS" gene complement(1656190..1657014) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /label="ymaE gene" promotor_-10 complement(1657036..1657055) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1657052) /Source="Nicolas_upshifts" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1657067..1657073) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1657125..1658453) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10589719, 16267290, 17884659, 28693413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10589719, 16267290, 17884659, 28693413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline serine protease" /protein_id="NP_389608.1" /db_xref="EnsemblGenomes-Gn:BSU17260" /db_xref="EnsemblGenomes-Tr:CAB13610" /db_xref="GOA:O31788" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG12567" /db_xref="UniProtKB/Swiss-Prot:O31788" /translation="MFGYSMVQMVRANAHKLDWPLRETVLQLYKPFKWTPCFLHKFFE TKLQNRKKMSVIIEFEEGCHETGFQMAGEVLQKEKRSKLKSRFNKINCCSAEVTPSAL HSLLSECSNIRKVYLNREVKALLDTATEASHAKEVVRNGQTLTGKGVTVAVVDTGIYP HPDLEGRIIGFADMVNQKTEPYDDNGHGTHCAGDVASSGASSSGQYRGPAPEANLIGV KVLNKQGSGTLADIIEGVEWCIQYNEDNPDEPIDIMSMSLGGDALRYDHEQEDPLVRA VEEAWSAGIVVCVAAGNSGPDSQTIASPGVSEKVITVGALDDNNTASSDDDTVASFSS RGPTVYGKEKPDILAPGVNIISLRSPNSYIDKLQKSSRVGSQYFTMSGTSMATPICAG IAALILQQNPDLTPDEVKELLKNGTDKWKDEDPNIYGAGAVNAENSVPGQ*" /label="aprX CDS" gene complement(1657125..1658453) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /label="aprX gene" downshifts complement(1657132) /Source="Nicolas_upshifts" /id="D930" /incds=0 /nref=13 /ntot=21 /MaxReadThrough="2.43809" /MaxDrop="5.8915" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1376" /TUdmin=8 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1658476..1658495) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1658495) /Source="Nicolas_upshifts" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1658509..1658517) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1658610..1658617 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1658625..1658644) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1658633..1658652 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1658636) /Source="Nicolas_upshifts" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="upshifts" upshifts 1658639 /Source="Nicolas_upshifts" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1658657..1658664) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1658678..1658755 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of YmzE" /translation="MNFYLHRSLESQMPISIIYEERRND*" /label="ymzEn CDS" gene 1658678..1658755 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /pseudo /label="ymzEn gene" downshifts complement(1658680) /Source="Nicolas_upshifts" /id="D931" /incds=0 /nref=4 /ntot=7 /MaxReadThrough="1.51659" /MaxDrop="5.37668" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1377" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS 1658733..1658909 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of YmzE" /db_xref="PSEUDO:CAX52622.1" /translation="MKKDGTISKRTIIVRQKSKTKIKAFCFSKQQIRTFLLDSILSCD FVRTNKQNLYSAGR*" /label="ymzEc CDS" gene 1658733..1658909 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /pseudo /label="ymzEc gene" downshifts 1658890 /Source="Nicolas_upshifts" /id="D932" /incds=0 /nref=42 /ntot=207 /MaxReadThrough="4.03151" /MaxDrop="6.55778" /score="-0.929304655" /energy="-5.5" /TU="U1378" /idTUdmin="U1378" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature 1658935..1659123 /Source="Nicolas_S_feature" /locus_tag="new_1863194_1863382" /HighExp="H2O2, M40t90, C90, M40t45, C30, S8, HiOs, G135, T-4.40H, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S619" misc_feature 1659118..1659137 /Source="Nicolas_upshift_promotors" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1659125 /Source="Nicolas_upshifts" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1659189..1659896 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /EC_number="3.4.19.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16267290, 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="gamma-polyglutamate hydrolase (phage origin)" /protein_id="NP_389609.1" /db_xref="EnsemblGenomes-Gn:BSU17270" /db_xref="EnsemblGenomes-Tr:CAB13611" /db_xref="GOA:O31789" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13411" /db_xref="UniProtKB/Swiss-Prot:O31789" /translation="MRRFLLNVILVLAIVLFLRYVHYSLEPEPSNQPDTYSNFSSLAE NESPADYDISYNEKKGSKVLIMSPHGGRIEGGVSELVRYFNNEYSTYLFEGLKSHDNQ TLHITSTNFDEPLAKKKIKEHQYVVAFHGYKGENKNTLVGGTDRKRAKMIVRALERRG FSAELASSKSGLAGLNAENINNQGETGLSIQLEISREQREAFFDDFYYKNRKYTKNSE FYAYVSAIKGVLEKEYS*" /label="pghC CDS" gene 1659189..1659896 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /label="pghC gene" promotor_-35 1659907..1659913 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1659927..1659946 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1659931 /Source="Nicolas_upshifts" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1659966..1660418 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290, 22904090, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peroxiredoxin-related protein" /protein_id="NP_389610.1" /db_xref="EnsemblGenomes-Gn:BSU17280" /db_xref="EnsemblGenomes-Tr:CAB13612" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019905" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13412" /db_xref="UniProtKB/Swiss-Prot:O31790" /translation="MADHHFYLKANWPGNRNDVGTIESGNLITSISIPKEMDGPGEGT NPDEMLLGAAATCYIITLAAMMERSGLEKEDLQMESEGIVNVTKGVFTYKKIIHRPSV VLKHDASQDDVALAHKLCKKAESSCMISRAIQGNVELQLEASVKLGGE*" /label="ymaD CDS" gene 1659966..1660418 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /label="ymaD gene" downshifts 1660406 /Source="Nicolas_upshifts" /id="D933" /incds=0 /nref=44 /ntot=182 /MaxReadThrough="1.35366" /MaxDrop="6.07534" /score="17.0193804" /energy="-12.1" /TU="NA" /idTUdmin="U1379" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1660432..1660785) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 15849754, 16750162, 16850406, 18024586, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 15849754, 16750162, 16850406, 18024586, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389611.1" /db_xref="EnsemblGenomes-Gn:BSU17290" /db_xref="EnsemblGenomes-Tr:CAB13613" /db_xref="GOA:P0CW82" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12586" /db_xref="UniProtKB/Swiss-Prot:P0CW82" /translation="MRGLLYLALAIVSEVFGSTMLKLSEGFTQAWPIAGVIVGFLSAF TFLSFSLKTIDLSSAYATWSGVGTALTAIVGFLLFGETISLKGVFGLTLVIAGVVVLN QSKAHAEDKKQTACE*" /label="ebrB CDS" gene complement(1660432..1660785) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /label="ebrB gene" downshifts complement(1660473) /Source="Nicolas_upshifts" /id="D934" /incds=0 /nref=2 /ntot=45 /MaxReadThrough="0.84905" /MaxDrop="2.87924" /score="-2.89884673" /energy="-8.7" /TU="NA" /idTUdmin="U1381" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1660799..1661116) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 11104814, 17516673, 18024586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 11104814, 17516673, 18024586; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389612.1" /db_xref="EnsemblGenomes-Gn:BSU17300" /db_xref="EnsemblGenomes-Tr:CAB13614" /db_xref="GOA:P0CW80" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12585" /db_xref="UniProtKB/Swiss-Prot:P0CW80" /translation="MLIGYIFLTIAICSESIGAAMLKVSDGFKKWKPSALVVIGYSLA FYMLSLTLNHIPLSLSYATWSGAGTVLTTVIGVKWFKEDLNAKGLIGILLLLSGVVLL NWP*" /label="ebrA CDS" gene complement(1660799..1661116) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /label="ebrA gene" promotor_-10 complement(1661160..1661179) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1661168) /Source="Nicolas_upshifts" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1661194..1661201) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1661253..1661528) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19775244, 19933362, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19775244, 19933362, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein; cell wall associated protein" /protein_id="NP_389613.2" /db_xref="EnsemblGenomes-Gn:BSU17310" /db_xref="EnsemblGenomes-Tr:CAB13615" /db_xref="GOA:O31793" /db_xref="SubtiList:BG13415" /db_xref="UniProtKB/Swiss-Prot:O31793" /translation="MNELEHFSPEDTRIFGRPFGFGRPFGFGRPFGFGYGFGRPGFGY GFGRPFGFFGGPFIGGLAGGLIGSALFNPYLYGGYPYYPYAPFPFYY*" /label="ymaG CDS" gene complement(1661253..1661528) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /label="ymaG gene" downshifts complement(1661254) /Source="Nicolas_upshifts" /id="D935" /incds=0 /nref=38 /ntot=44 /MaxReadThrough="0.28059" /MaxDrop="8.33353" /score="12.3408391" /energy="-11.5" /TU="NA" /idTUdmin="U1383" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1661524..1661529 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-35" promotor_-10 1661545..1661563 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-10" promotor_-10 complement(1661555..1661574) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1661565 /Source="Nicolas_upshifts" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="upshifts" upshifts complement(1661568) /Source="Nicolas_upshifts" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1661587..1661596) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1661617..1662030 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24098137, 25915524" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein of unknown function" /protein_id="NP_389614.2" /db_xref="EnsemblGenomes-Gn:BSU17320" /db_xref="EnsemblGenomes-Tr:CAB13616" /db_xref="InterPro:IPR024307" /db_xref="SubtiList:BG13414" /db_xref="UniProtKB/Swiss-Prot:O31794" /translation="MNTLGLYQSDWSKAPPHAHAYHVKTTREQGHYHLIEGFTQPANG SNTDQHTHYYTGITSFENGHFHRYYGISGPAIPLADGTHYHEIEETTYLAYNEPIEIQ YGGVVYDPGDDRRKTHRHTLKGKTREIVGNEPLGW*" /label="ymaF CDS" gene 1661617..1662030 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /label="ymaF gene" upshifts 1662081 /Source="Nicolas_upshifts" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="upshifts" misc_feature 1662087..1662106 /Source="Nicolas_upshift_promotors" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1662130..1663074 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /EC_number="2.5.1.75" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3045085, 11160115, 26735940, 28277934, 28471404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA isopentenylpyrophosphate transferase" /protein_id="NP_389615.2" /db_xref="EnsemblGenomes-Gn:BSU17330" /db_xref="EnsemblGenomes-Tr:CAB13617" /db_xref="GOA:O31795" /db_xref="InterPro:IPR018022" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12617" /db_xref="UniProtKB/Swiss-Prot:O31795" /translation="MNNTKQPVVILVGPTAVGKTNLSIQLAKSLNAEIISGDSMQIYK GMDIGTAKITEQEMEGVPHHLIDILDPQDSFSTADYQSLVRNKISEIANRGKLPMIVG GTGLYIQSVLYDYTFTEEANDPVFRESMQMAAEREGADFLHAKLAAADPEAAAAIHPN NTRRVIRALEILHTSGKTMSQHLKEQKRELLYNAVLIGLTMDRDTLYERINQRVDLMM QSGLLPEVKRLYDKNVRDCQSIQAIGYKELYAYFDGFVTLSDAVEQLKQNSRRYAKRQ LTWFRNKMQVTWFDMTPPVDMELKKKEIFTHIAGKLEL*" /label="miaA CDS" gene 1662130..1663074 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /label="miaA gene" promotor_-35 1663054..1663062 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-35" promotor_-10 1663073..1663091 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-10" upshifts 1663075 /Source="Nicolas_upshifts" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="upshifts" CDS 1663114..1663335 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927; Product type f: factor" /codon_start=1 /transl_table=11 /product="Hfq RNA chaperone" /protein_id="NP_389616.1" /db_xref="EnsemblGenomes-Gn:BSU17340" /db_xref="EnsemblGenomes-Tr:CAB13618" /db_xref="GOA:O31796" /db_xref="InterPro:IPR005001" /db_xref="InterPro:IPR010920" /db_xref="PDB:3AHU" /db_xref="PDB:3HSB" /db_xref="SubtiList:BG13416" /db_xref="UniProtKB/Swiss-Prot:O31796" /translation="MKPINIQDQFLNQIRKENTYVTVFLLNGFQLRGQVKGFDNFTVL LESEGKQQLIYKHAISTFAPQKNVQLELE*" /label="hfq CDS" gene 1663114..1663335 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /label="hfq gene" downshifts complement(1663125) /Source="Nicolas_upshifts" /id="D936" /incds=0 /nref=3 /ntot=108 /MaxReadThrough="1.19472" /MaxDrop="3.56162" /score="-5.83707008" /energy="-5.2" /TU="NA" /idTUdmin="U1386" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1663187..1663191) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1663191) /Source="Nicolas_upshifts" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1663206..1663211) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1663335 /Source="Nicolas_upshifts" /id="D937" /incds=0 /nref=26 /ntot=212 /MaxReadThrough="5.10866" /MaxDrop="4.06475" /score="17.2354231" /energy="-17" /TU="U1382,U1385" /idTUdmin="U1384" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1663531..1663803 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389617.1" /db_xref="EnsemblGenomes-Gn:BSU17350" /db_xref="EnsemblGenomes-Tr:CAB13619" /db_xref="InterPro:IPR025448" /db_xref="PDB:3KVP" /db_xref="SubtiList:BG13436" /db_xref="UniProtKB/Swiss-Prot:O31797" /translation="MFESEAELRRIRIALVWIAVFLLFGACGNQDTIIETDNGNSDYE TPQPTSFPLEHNHFGVMEDGYIKIYEYNESRNEVKLKKEYADDELE*" /label="ymzC CDS" gene 1663531..1663803 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /label="ymzC gene" promotor_-35 1663819..1663826 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1663840..1663859 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1663842 /Source="Nicolas_upshifts" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="upshifts" CDS 1663885..1664115 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389618.1" /db_xref="EnsemblGenomes-Gn:BSU17360" /db_xref="EnsemblGenomes-Tr:CAB13620" /db_xref="SubtiList:BG13434" /db_xref="UniProtKB/Swiss-Prot:O31798" /translation="MKHKVIVNHWEEICEDDSCYEYGTSIIVNGKELIREASIITALK AVLEEIGADVEIEETVESEKCCDSLRKKNLDY*" /label="ymzA CDS" gene 1663885..1664115 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /label="ymzA gene" S_feature 1664116..1664192 /Source="Nicolas_S_feature" /locus_tag="new_1868375_1868451" /HighExp="dia5, dia15, Diami, B60, G150, H2O2, LPhT, G180, G135, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S620" downshifts 1664149 /Source="Nicolas_upshifts" /id="D938" /incds=0 /nref=24 /ntot=61 /MaxReadThrough="7.47169" /MaxDrop="4.19691" /score="8.2587309" /energy="-16.9" /TU="U1385,U1387" /idTUdmin="U1385" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 1664194..1664301 /Source="Nicolas_S_feature" /locus_tag="new_1868453_1868560" /HighExp="G180, G150, G135, H2O2, dia15, Paraq, LBGexp, C30, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S621" promotor_-35 1664274..1664281 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1664295..1664314 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1664303 /Source="Nicolas_upshifts" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="upshifts" CDS 1664358..1664750 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16885274, 21561096, 22443445, 23402532, 26507228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16885274, 21561096, 22443445, 23402532, 26507228; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-factor of ribonucleotide diphosphate reductase" /protein_id="NP_389619.1" /db_xref="EnsemblGenomes-Gn:BSU17370" /db_xref="EnsemblGenomes-Tr:CAB13621" /db_xref="GOA:P50618" /db_xref="InterPro:IPR004465" /db_xref="InterPro:IPR020852" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLJ" /db_xref="SubtiList:BG11426" /db_xref="UniProtKB/Swiss-Prot:P50618" /translation="MVQIIFDSKTGNVQRFVNKTGFQQIRKVDEMDHVDTPFVLVTYT TNFGQVPASTQSFLEKYAHLLLGVAASGNKVWGDNFAKSADTISRQYQVPILHKFELS GTSKDVELFTQEVERVVTKSSAKMDPVK*" /label="nrdI CDS" gene 1664358..1664750 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /label="nrdI gene" CDS 1664710..1666812 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (major subunit)" /protein_id="NP_389620.1" /db_xref="EnsemblGenomes-Gn:BSU17380" /db_xref="EnsemblGenomes-Tr:CAB13622" /db_xref="GOA:P50620" /db_xref="InterPro:IPR000788" /db_xref="InterPro:IPR008926" /db_xref="InterPro:IPR013346" /db_xref="InterPro:IPR013509" /db_xref="InterPro:IPR013554" /db_xref="InterPro:IPR026459" /db_xref="SubtiList:BG11404" /db_xref="UniProtKB/Swiss-Prot:P50620" /translation="MSQNQVPKWIQLNNEIMIQKDGKFQFDKDKEAVHSYFVDYINQN TVFFHNLKEKLDYLVENQYYEEEFLSLYSFEDIKEVFKTAYAKKFRFPSFMSAFKFYN DYALKTNDKKKILERYEDRISIVALFFANGDTEKAKEYVNLMINQEYQPSTPTFLNAG RKRRGELVSCFLLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLRAKGEAIKDVEN ATKGVVGVMKLLDNAFRYADQMGQRQGSGAAYLNIFHRDINDFLDTKKISADEDVRVK TLSIGVVIPDKFVELAREDKAAYVFYPHTIYKEYGQHMDEMDMNEMYDKFVDNPRVKK EKINPRKLLEKLAMLRSESGYPYIMFQDNVNKVHANNHISKVKFSNLCSEVLQASQVS SYTDYDEEDEIGLDISCNLGSLNILNVMEHKSIEKTVKLATDSLTHVSETTDIRNAPA VRRANKAMKSIGLGAMNLHGYLAQNGIAYESPEARDFANTFFMMVNFYSIQRSAEIAK EKGETFDQYEGSTYATGEYFDKYVSTDFSPKYEKIANLFEGMHIPTTEDWKKLKAFVA EHGMYHSYRLCIAPTGSISYVQSSTASVMPIMERIEERTYGNSKTYYPMPGLASNNWF FYKEAYDMDMFKVVDMIATIQQHIDQGISFTLFLKDTMTTRDLNRIDLYAHHRGIKTI YYARTKDTGQDSCLSCVV*" /label="nrdE CDS" gene 1664710..1666812 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /label="nrdE gene" CDS 1666830..1667819 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (minor subunit)" /protein_id="NP_389621.1" /db_xref="EnsemblGenomes-Gn:BSU17390" /db_xref="EnsemblGenomes-Tr:CAB13623" /db_xref="GOA:P50621" /db_xref="InterPro:IPR000358" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR026494" /db_xref="InterPro:IPR030475" /db_xref="InterPro:IPR033909" /db_xref="PDB:4DR0" /db_xref="SubtiList:BG11405" /db_xref="UniProtKB/Swiss-Prot:P50621" /translation="MTKIYDAANWSKHEDDFTQMFYNQNVKQFWLPEEIALNGDLLTW KYLGKNEQDTYMKVLAGLTLLDTEQGNTGMPIVAEHVDGHQRKAVLNFMAMMENAVHA KSYSNIFMTLAPTETINEVFEWVKQNKYLQKKAQMIVGLYKAIQKDDEISLFKAMVAS VYLESFLFYSGFYYPLYFYGQGKLMQSGEIINLILRDEAIHGVYVGLLAQEIYNKQTE EKKAELREFAIDLLNQLYENELEYTEDLYDQVGLSHDVKKFIRYNANKALMNLGFDPY FEEEDINPIVLNGLNTKTKSHDFFSMKGNGYKKATVEPLKDDDFYFEDEKEQI*" /label="nrdF CDS" gene 1666830..1667819 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /label="nrdF gene" downshifts 1667779 /Source="Nicolas_upshifts" /id="D939" /incds=0 /nref=3 /ntot=106 /MaxReadThrough="6.49299" /MaxDrop="2.8143" /score="-8.26008921" /energy="-10.8" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(1667833..1668492) /Source="Nicolas_S_feature" /locus_tag="new_1872092_1872751_c" /HighExp="BT, B36, C30, Pyr, S8, G135, G/S, Glucon, B60, C90" /AntisenseName="ymaB" /AntisenseCor="-0.136438199650502" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S622" downshifts complement(1667848) /Source="Nicolas_upshifts" /id="D940" /incds=0 /nref=3 /ntot=8 /MaxReadThrough="2.78803" /MaxDrop="4.0424" /score="6.77419677" /energy="-10.8" /TU="NA" /idTUdmin="U1390" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 1667869..1668489 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885274, 21561096; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative cofactor involved in deoxyribonucleotide synthesis" /protein_id="NP_389622.1" /db_xref="EnsemblGenomes-Gn:BSU17400" /db_xref="EnsemblGenomes-Tr:CAB13624" /db_xref="GOA:P50619" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG11427" /db_xref="UniProtKB/Swiss-Prot:P50619" /translation="MGKMDEMILVAPRDDVFKKESLTFQGVYSEDSRVAEIMAQIEAA YREMRRGDAEEDPRFKQPIPYVVIKREDEVFLYERLAGGGESRLHNKLSLGFGGHMNA IEGAASFAEVLKLNTDRELEEELQINEEDKQAIVTLGLINDDENSVGKVHIGILSALQ LKPGAQVEVKEKEQIAGKWMKVSELKQDDIYNRLETWSQFVVDILE*" /label="ymaB CDS" gene 1667869..1668489 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /label="ymaB gene" downshifts 1668470 /Source="Nicolas_upshifts" /id="D941" /incds=0 /nref=130 /ntot=257 /MaxReadThrough="4.3301" /MaxDrop="6.0751" /score="31.3992458" /energy="-16.3" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-35" /isTUend="FALSE" /label="downshifts" promotor_-35 1668505..1668509 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1668527..1668894 /Source="Nicolas_S_feature" /locus_tag="new_1872786_1873153" /HighExp="dia15, G180, H2O2, G135, G150, Diami, Paraq, Oxctl, LBGexp, C30" /AntisenseName="cwlC" /AntisenseCor="-8.9131707018362205E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.231, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S623" upshifts 1668527 /Source="Nicolas_upshifts" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1668531..1668548 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1668537) /Source="Nicolas_upshifts" /id="D942" /incds=0 /nref=1 /ntot=53 /MaxReadThrough="7.25519" /MaxDrop="4.6417" /score="9.14776993" /energy="-8.9" /TU="U1390" /idTUdmin="U1390" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS complement(1668553..1669320) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /EC_number="3.5.1.28" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10515909, 10945275, 10974124, 11375403, 16042392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10945275, 10974124, 11375403, 16042392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (sporulation-specific)" /protein_id="NP_389623.2" /db_xref="EnsemblGenomes-Gn:BSU17410" /db_xref="EnsemblGenomes-Tr:CAB13625" /db_xref="GOA:Q06320" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="PDB:1X60" /db_xref="SubtiList:BG10825" /db_xref="UniProtKB/Swiss-Prot:Q06320" /translation="MVKIFIDPGHGGSDPGATGNGLQEKTLTLQIALALRTILTNEYE GVSLLLSRTSDQYVSLNDRTNAANNWGADFFLSIHVNSGGGTGFESYIYPDVGAPTTT YQSTIHSEVIQAVDFADRGKKTANFHVLRESAMPALLTENGFIDTVSDANKLKTSSFI QSLARGHANGLEQAFNLKKTSSSGLYKVQIGAFKVKANADSLASNAEAKGFDSIVLLK DGLYKVQIGAFSSKDNADTLAARAKNAGFDAIVILES*" /label="cwlC CDS" gene complement(1668553..1669320) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /label="cwlC gene" promotor_-10 complement(1669329..1669348) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1669352) /Source="Nicolas_upshifts" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1669361..1669370) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1669474..1669479 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1669495..1669513 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1669495 /Source="Nicolas_upshifts" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1669777..1669782 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-35" promotor_-10 1669799..1669817 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-10" S_feature 1669803..1669943 /Source="Nicolas_S_feature" /locus_tag="new_1874062_1874202" /HighExp="S4, S5, S6, S8, S3, B60, LoTm, S7, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.777" /TUlongSig="NA" /TUlongPSig="NA" /label="S624" upshifts 1669803 /Source="Nicolas_upshifts" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="upshifts" CDS 1669944..1670912 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8464402, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="mother cell sporulation ATPase" /protein_id="NP_389624.2" /db_xref="EnsemblGenomes-Gn:BSU17420" /db_xref="EnsemblGenomes-Tr:CAB13626" /db_xref="GOA:P27643" /db_xref="InterPro:IPR000641" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR014232" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11039" /db_xref="UniProtKB/Swiss-Prot:P27643" /translation="MLERAVTYKNNGQINIILNGQKQVLTNAEAEAEYQAALQKNEAK HGILKEIEKEMSALVGMEEMKRNIKEIYAWIFVNQKRAEQGLKVGKQALHMMFKGNPG TGKTTVARLIGKLFFEMNVLSKGHLIEAERADLVGEYIGHTAQKTRDLIKKSLGGILF IDEAYSLARGGEKDFGKEAIDTLVKHMEDKQHEFILILAGYSREMDHFLSLNPGLQSR FPISIDFPDYSVTQLMEIAKRMIDEREYQLSQEAEWKLKDYLMTVKSTTSPIKFSNGR FVRNVIEKSIRAQAMRLLMGDQYLKSDLMTIKSQDLSIKEEASGSA*" /label="spoVK CDS" gene 1669944..1670912 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /label="spoVK gene" downshifts 1670881 /Source="Nicolas_upshifts" /id="D943" /incds=0 /nref=5 /ntot=41 /MaxReadThrough="2.7881" /MaxDrop="5.20495" /score="22.9164064" /energy="-15.5" /TU="U1392" /idTUdmin="U1392" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-35 1670976..1670984 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-35" upshifts 1670991 /Source="Nicolas_upshifts" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="upshifts" promotor_-10 1670995..1671014 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-10" CDS 1671045..1672307 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19824612, 26458047, 26733579, 26951678, 27398305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-splitting GTPase (also ATPase, rescuingstalled ribosomes, E-site binding)" /protein_id="NP_389625.2" /db_xref="EnsemblGenomes-Gn:BSU17430" /db_xref="EnsemblGenomes-Tr:CAB13627" /db_xref="GOA:P94478" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016496" /db_xref="InterPro:IPR025121" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030394" /db_xref="InterPro:IPR032305" /db_xref="SubtiList:BG12263" /db_xref="UniProtKB/Swiss-Prot:P94478" /translation="MNEQETIQEKAILVGCQLPHITDEHFENSMEELASLTKTADGKV LTSVTQKRNRADAATYIGKGKVEELKALVEELEADLLIFNDELSPSQLKSLATAIEVK MIDRTQLILDIFAKRARTREGKLQIELAQLQYALPRLTGQGINLSRQGGGIGARGPGE TKLETDRRHIRNRIHEINTQLSTVIRHRSRYRERRKKNGVLQIALVGYTNAGKSTWFN RLTSADSYEEDLLFATLDPMTRKMVLPSGYSVLLSDTVGFIQDLPTTLIAAFRSTLEE VKEADLILHLIDSSNEDYAGHEKTVLRLLEELEADDIPMLTAYNKRDQKLPDFIPTAG RDHIMVSAKFEDDAAAFKEAIQRYLRQELLTSFEAHVPASEGKLLSRIKSETMVDRFY FNEENEQYDISGYVQEEQSIIGELKKYM*" /label="hflX CDS" gene 1671045..1672307 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /label="hflX gene" CDS 1672325..1673590 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 24610841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_389626.2" /db_xref="EnsemblGenomes-Gn:BSU17440" /db_xref="EnsemblGenomes-Tr:CAB13628" /db_xref="GOA:P94479" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR009651" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12264" /db_xref="UniProtKB/Swiss-Prot:P94479" /translation="MFDTLTHGELLKKTAMEVEADIAGIHKQIEEISERNEWRVLQSY RKHKVSDTHFTPSTGYGYDDIGRDTLESIYADVFGGEAGLVRPQIISGTHAISIALFG VLRPGDELLYITGKPYDTLEEIVGVRGGENAGSLKDFQIGYNAVDLTKDGKIDYDAVA AAINPKTKVIGIQRSKGYANRPSFLISEIKEMIRFVKEINENLIVFVDNCYGEFVEEL EPCHVGADLMAGSLIKNPGGGLAKTGGYLVGKAKWIEACSYRMTSPGIGREAGASLYS LQEMYQGFFLAPHVVSQSLKGAVFTARFLEKLGFTSNPKWDAKRTDLIQSVEFSDREK MIAFCQAIQFASPINAHVTPYPAYMPGYEDDVIMAAGTFIQGASIELSADGPIRPPYV AYVQGGLTYSHVKNAICSAVDSLMQKQLI*" /label="ynbB CDS" gene 1672325..1673590 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /label="ynbB gene" promotor_-35 1673638..1673645 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-35" promotor_-10 1673660..1673679 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-10" upshifts 1673672 /Source="Nicolas_upshifts" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="upshifts" CDS 1673700..1674107 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (nitrogen metabolism)" /protein_id="NP_389627.1" /db_xref="EnsemblGenomes-Gn:BSU17450" /db_xref="EnsemblGenomes-Tr:CAB13629" /db_xref="GOA:P37582" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4R4E" /db_xref="SubtiList:BG10424" /db_xref="UniProtKB/Swiss-Prot:P37582" /translation="MSDNIRRSMPLFPIGIVMQLTELSARQIRYYEENGLIFPARSEG NRRLFSFHDVDKLLEIKHLIEQGVNMAGIKQILAKAEAEPEQKQNEKTKKPMKHDLSD DELRQLLKNELMQAGRFQRGNTFRQGDMSRFFH*" /label="glnR CDS" gene 1673700..1674107 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /label="glnR gene" downshifts complement(1673706) /Source="Nicolas_upshifts" /id="D944" /incds=0 /nref=2 /ntot=82 /MaxReadThrough="1.78139" /MaxDrop="3.45896" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3816 /isTUend="FALSE" /label="downshifts" misc_feature 1674088..1674106 /Source="Nicolas_upshift_promotors" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1674113 /Source="Nicolas_upshifts" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1674166) /Source="Nicolas_upshifts" /id="D945" /incds=0 /nref=1 /ntot=72 /MaxReadThrough="1.70567" /MaxDrop="3.42395" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3356 /isTUend="FALSE" /label="downshifts" CDS 1674166..1675500 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /EC_number="6.3.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine synthetase" /protein_id="NP_389628.1" /db_xref="EnsemblGenomes-Gn:BSU17460" /db_xref="EnsemblGenomes-Tr:CAB13630" /db_xref="GOA:P12425" /db_xref="InterPro:IPR001637" /db_xref="InterPro:IPR004809" /db_xref="InterPro:IPR008146" /db_xref="InterPro:IPR008147" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR027302" /db_xref="InterPro:IPR027303" /db_xref="InterPro:IPR036651" /db_xref="PDB:2FWX" /db_xref="PDB:4LNF" /db_xref="PDB:4LNI" /db_xref="PDB:4LNK" /db_xref="PDB:4LNN" /db_xref="PDB:4LNO" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG10425" /db_xref="UniProtKB/Swiss-Prot:P12425" /translation="MAKYTREDIEKLVKEENVKYIRLQFTDILGTIKNVEIPVSQLGK ALDNKVMFDGSSIEGFVRIEESDMYLYPDLNTFVIFPWTAEKGKVARFICDIYNPDGT PFEGDPRNNLKRILKEMEDLGFSDFNLGPEPEFFLFKLDEKGEPTLELNDKGGYFDLA PTDLGENCRRDIVLELEEMGFEIEASHHEVAPGQHEIDFKYAGAVRSCDDIQTFKLVV KTIARKHGLHATFMPKPLFGVNGSGMHCNLSLFKNGVNAFFDENADLQLSETAKHFIA GIVKHATSFTAVTNPTVNSYKRLVPGYEAPCYVAWSAQNRSPLIRIPASRGISTRVEV RSVDPAANPYLALSVLLAAGLDGIKNKLEAPAPIDRNIYVMSKEERMENGIVDLPATL AEALEEFKSNEVMVKALGEHLFEHFIEAKEIEWDMFRTQVHPWEREQYMSQY*" /label="glnA CDS" gene 1674166..1675500 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /label="glnA gene" downshifts 1675477 /Source="Nicolas_upshifts" /id="D946" /incds=0 /nref=266 /ntot=287 /MaxReadThrough="5.53201" /MaxDrop="7.28613" /score="29.7599306" /energy="-16.4" /TU="U1394,U1395" /idTUdmin="U1393" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature 1675522..>1675571 /Source="Nicolas_S_feature" /locus_tag="new_1879781_1880041" /HighExp="Cold, BT, LBGtran, G135, G180, Etha, G150, LBGexp, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.777, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S625" SCAR 1675571..1675572 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs04" S_feature <1675572..1676324 /Source="Nicolas_S_feature" /locus_tag="new_1886528_1887351" /HighExp="Lbstat, M0t90, S8, C30, Pyr, Lbtran, M40t90, S1, M/G, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S631" promotor_-10 complement(1675664..1675682) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1675682) /Source="Nicolas_upshifts" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1675698..1675703) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1676325..1677716 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16684115, 16850406, 17183216, 20406496; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+-xyloside symporter" /protein_id="NP_389639.2" /db_xref="EnsemblGenomes-Gn:BSU17570" /db_xref="EnsemblGenomes-Tr:CAB13641" /db_xref="GOA:P94488" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12262" /db_xref="UniProtKB/Swiss-Prot:P94488" /translation="MLSENVKKISMVEKVGYASGDFACNLIYATVSTYLLFFYTDVFG LSAAAAGTMFLVVRIIDALADPFIGTIVDRTNSRFGRFRPYLLFGAFPFVILAILCFT TPDFSDMGKLIYAYITYVGLSLTYTTINVPYGALTSAMTRNNQEVVSITSVRMLFANL GGLVVAFFVPLLAAYLSDTSGNESLGWQLTMGILGMIGGCLLIFCFKSTKERVTLQKS EEKIKFTDIFEQFRVNRPLVVLSIFFIIIFGVNSISNSVGIYYVTYNLEREDLVKWYG LIGSLPALVILPFIPRLHQFLGKKKLLNYALLLNIIGLLALLFVPPSNVYLILVCRLI AAAGSLTAGGYMWALIPETIEYGEYRTGKRMGGLIYAIIGFFFKFGMALGGVVPGLVL DKFGYVANQAQTPAALMGILITTTIIPVFLLVLALIDINFYNLDEKKYKNMVRELENR DKVYLDHIDDFKA*" /label="xynP CDS" gene 1676325..1677716 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /label="xynP gene" CDS 1677747..1679348 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /EC_number="3.2.1.37" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2440680, 6413490, 7816035, 9286998, 9973552, 16684115, 28066362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylan beta-1,4-xylosidase" /protein_id="NP_389640.2" /db_xref="EnsemblGenomes-Gn:BSU17580" /db_xref="EnsemblGenomes-Tr:CAB13642" /db_xref="GOA:P94489" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="PDB:1YIF" /db_xref="SubtiList:BG11987" /db_xref="UniProtKB/Swiss-Prot:P94489" /translation="MKITNPVLKGFNPDPSICRAGEDYYIAVSTFEWFPGVQIHHSKD LVNWHLVAHPLQRVSQLDMKGNPNSGGVWAPCLSYSDGKFWLIYTDVKVVDGAWKDCH NYLVTCETINGDWSEPIKLNSSGFDASLFHDTDGKKYLLNMLWDHRIDRHSFGGIVIQ EYSDKEQKLIGKPKVIFEGTDRKLTEAPHLYHIGNYYYLLTAEGGTRYEHAATIARSA NIEGPYEVHPDNPILTSWHDPGNPLQKCGHASIVQTHTDEWYLAHLTGRPIHPDDDSI FQQRGYCPLGRETAIQKLYWKDEWPYVVGGKEGSLEVDAPSIPETIFEATYPEVDEFE DSTLNINFQTLRIPFTNELGSLTQAPNHLRLFGHESLTSTFTQAFVARRWQSLHFEAE TAVEFYPENFQQAAGLVNYYNTENWTALQVTHDEELGRILELTICDNFSFSQPLNNKI VIPREVKYVYLRVNIEKDKYYYFYSFNKEDWHKIDIALESKKLSDDYIRGGGFFTGAF VGMQCQDTSGNHIPADFRYFRYKEK*" /label="xynB CDS" gene 1677747..1679348 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /label="xynB gene" S_feature complement(1677863..1678168) /Source="Nicolas_S_feature" /locus_tag="new_1888890_1889195_c" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, S4, B36, BC" /AntisenseName="xynB" /AntisenseCor="6.2527836498644102E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S632" promotor_-10 complement(1678163..1678182) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1678168) /Source="Nicolas_upshifts" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1678196..1678204) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1679346 /Source="Nicolas_upshifts" /id="D951" /incds=0 /nref=2 /ntot=53 /MaxReadThrough="1.32947" /MaxDrop="3.8449" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1400" /TUdmin=3190 /isTUend="FALSE" /label="downshifts" CDS complement(1679485..1680639) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1588910, 1719948, 2544559, 7559331; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389641.3" /db_xref="EnsemblGenomes-Gn:BSU17590" /db_xref="EnsemblGenomes-Tr:CAB13643" /db_xref="GOA:P94490" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11986" /db_xref="UniProtKB/Swiss-Prot:P94490" /translation="MDIADQTFVKKVNQKLLLKEILKNSPISRAKLSEMTGLNKSTVS SQVNTLMKESMVFEIGQGQSSGGRRPVMLVFNKKAGYSVGIDVGVDYINGILTDLEGT IVLDQYRHLESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQKIVF TPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIG IGVIINNHLYRGVSGFSGEMGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKEK KLSYQDIINLAHLNDIGTLNALQNFGFYLGIGLTNILNTFNPQAVILRNSIIESHPMV LNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDHFLDMITM*" /label="xylR CDS" gene complement(1679485..1680639) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /label="xylR gene" downshifts complement(1679488) /Source="Nicolas_upshifts" /id="D952" /incds=0 /nref=9 /ntot=198 /MaxReadThrough="2.56326" /MaxDrop="4.09398" /score="19.297583" /energy="-7.4" /TU="NA" /idTUdmin="U1405" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1680538..1680716) /Source="Nicolas_S_feature" /locus_tag="new_1891565_1891743_c" /HighExp="dia15, Etha, dia5, dia0, Cold, LBGstat, Lbexp, M0t45, Diami, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S633" promotor_-35 1680684..1680690 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1680699..1680718) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1680700..1680716 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1680710 /Source="Nicolas_upshifts" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1680716) /Source="Nicolas_upshifts" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1680733..1680736) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1680743..1680750 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1680765..1680784 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1680776..1680880 /Source="Nicolas_S_feature" /locus_tag="new_1891803_1891907" /HighExp="dia15, dia0, Lbexp, dia5, B60, Sw, G150, LPhT, Mt0, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S634" upshifts 1680777 /Source="Nicolas_upshifts" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="upshifts" CDS 1680881..1682218 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /EC_number="5.3.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7663444, 8132469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7663444, 8132469; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylose isomerase" /protein_id="NP_389642.2" /db_xref="EnsemblGenomes-Gn:BSU17600" /db_xref="EnsemblGenomes-Tr:CAB13644" /db_xref="GOA:P0CI80" /db_xref="InterPro:IPR001998" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR013452" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG10806" /db_xref="UniProtKB/Swiss-Prot:P0CI80" /translation="MAQSHSSSINYFGSANKVVYEGKDSTNPLAFKYYNPQEVIGGKT LKEHLRFSIAYWHTFTADGTDVFGAATMQRPWDHYKGMDLAKMRVEAAFEMFEKLDAP FFAFHDRDIAPEGSTLKETNQNLDMIMGMIKDYMRNSGVKLLWNTANMFTNPRFVHGA ATSCNADVFAYAAAQVKKGLETAKELGAENYVFWGGREGYETLLNTDLKFELDNLARF MHMAVDYAKEIGYTGQFLIEPKPKEPTTHQYDTDAATTIAFLKQYGLDNHFKLNLEAN HATLAGHTFEHELRMARVHGLLGSVDANQGHPLLGWDTDEFPTDLYSTTLAMYEILQN GGLGSGGLNFDAKVRRSSFEPDDLIYAHIAGMDAFARGLKVAHKLIEDRVFEDVIQHR YRSFTEGIGLEIIEGRANFHTLEQYALNHKSIKNESGRQEKLKAILNQYILEV*" /label="xylA CDS" gene 1680881..1682218 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /label="xylA gene" S_feature 1682219..1682293 /Source="Nicolas_S_feature" /locus_tag="new_1893246_1893320" /HighExp="dia0, dia15, Sw, Lbexp, dia5, B60, Mt0, M0t45, G150, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S635" downshifts 1682250 /Source="Nicolas_upshifts" /id="D953" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="4.89699" /MaxDrop="3.40404" /score="13.0570501" /energy="-10.2" /TU="U1406" /idTUdmin="U1406" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" CDS 1682369..1683868 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /EC_number="2.7.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1660563, 8866023, 27467131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylulose kinase" /protein_id="NP_389643.1" /db_xref="EnsemblGenomes-Gn:BSU17610" /db_xref="EnsemblGenomes-Tr:CAB13645" /db_xref="GOA:P39211" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006000" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10807" /db_xref="UniProtKB/Swiss-Prot:P39211" /translation="MKYVIGIDLGTSAVKTILVNQNGKVCAETSKRYPLIQEKAGYSE QNPEDWVQQTIEALAELVSISNVQAKDIDGISYSGQMHGLVLLDQDRQVLRNAILWND TRTTPQCIRMTEKFGDHLLDITKNRVLEGFTLPKMLWVKEHEPELFKKTAVFLLPKDY VRFRMTGVIHTEYSDAAGTLLLHITRKEWSNDICNQIGISADICPPLVESHDCVGSLL PHVAAKTGLLEKTKVYAGGADNACGAIGAGILSSGKTLCSIGTSGVILSYEEEKERDF KGKVHFFNHGKKDSFYTMGVTLAAGYSLDWFKRTFAPNESFEQLLQGVEAIPIGANGL LYTPYLVGERTPHADSSIRGSLIGMDGAHNRKHFLRAIMEGITFSLHESIELFREAGK SVHTVVSIGGGAKNDTWLQMQADIFNTRVIKLENEQGPAMGAAMLAAFGSGWFESLEE CAEQFIREAAAFYPKAQNVQKYKTLFDLYKNIYTHTKDLNTALKSFRKN*" /label="xylB CDS" gene 1682369..1683868 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /label="xylB gene" S_feature 1683869..1684184 /Source="Nicolas_S_feature" /locus_tag="new_1894896_1895211" /HighExp="dia0, dia15, Lbexp, dia5, Mt0, M0t45, G150, Etha, Diami, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.51323200000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S636" downshifts 1684142 /Source="Nicolas_upshifts" /id="D954" /incds=0 /nref=60 /ntot=197 /MaxReadThrough="0.61776" /MaxDrop="5.13425" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1684351..1684986) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11584000" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11584000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA nuclease, lipoprotein (phage origin)" /protein_id="NP_389644.1" /db_xref="EnsemblGenomes-Gn:BSU17620" /db_xref="EnsemblGenomes-Tr:CAB13646" /db_xref="GOA:P94492" /db_xref="InterPro:IPR002071" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR035437" /db_xref="SubtiList:BG12265" /db_xref="UniProtKB/Swiss-Prot:P94492" /translation="MKKILISMIAIVLSITLAACGSNHAAKNHSDSNGTEQVSQDTHS NEYNQTEQKAGTPHSKNQKKLVNVTLDRAIDGDTIKVIYNGKKDTVRYLLVDTPETKK PNSCVQPYGEDASKRNKELVNSGKLQLEFDKGDRRDKYGRLLAYVYVDGKSVQETLLK EGLARVAYVYEPNTKYIDQFRLDEQEAKSDKLSIWSKSGYVTNRGFNGCVK*" /label="yncB CDS" gene complement(1684351..1684986) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /label="yncB gene" promotor_-10 complement(1685023..1685042) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1685032) /Source="Nicolas_upshifts" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1685057..1685064) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1685174..1685181 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1685196..1685215 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1685198..1685396 /Source="Nicolas_S_feature" /locus_tag="new_1896225_1896423" /HighExp="T0.30H, Lbtran, T1.0H, M9-stat, M0t90, T1.30H, M40t90, T2.0H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S637" upshifts 1685198 /Source="Nicolas_upshifts" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="upshifts" CDS 1685397..1686812 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22900538, 23569278; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar transporter" /protein_id="NP_389645.2" /db_xref="EnsemblGenomes-Gn:BSU17630" /db_xref="EnsemblGenomes-Tr:CAB13647" /db_xref="GOA:P94493" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12266" /db_xref="UniProtKB/Swiss-Prot:P94493" /translation="MDMNEHRNRRLKLIMISATFGGLLFGYDTGVINGALPFMARPDQ LDLTPVTEGLVTSILLLGAAFGALLCGRLADRYGRRKMILNLSFLFFLASLGTALAPN VFIMAVFRFLLGLAVGGASAMVPAFLAEMAPHEKRGRMVTQNELMIVGGQFLAYVFNA ILGVTMANTGHVWRYMLVICAVPAIMLFASMLKVPESPRWLISKGKNSEALRVLKQIR EDKRAEAECREIQEAVEKDTALEKASLKDFSTPWLRRLLWIGIGVAIVNQITGVNSIM YYGTQILKESGFGTKAALIANIGNGLISVIAVIFGIWLVGKVRRRPILLIGLAGTTTA LLLIAIFSIVLDGSMALPYVVLSLTVLFLAFMQGCVGPVTWLVIAEIFPQRLRGLGSG ISVFFLWILNFVIGFAFPILLSSVGLSFTFFIFVALGVLAIGFVYKFMPETKGRTLEE LEEHFRSRHDHNTPEQSVIEV*" /label="yncC CDS" gene 1685397..1686812 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /label="yncC gene" downshifts 1686802 /Source="Nicolas_upshifts" /id="D955" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="0.90595" /MaxDrop="4.35189" /score="15.579587" /energy="-8.6" /TU="NA" /idTUdmin="U1408" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(1686905) /Source="Nicolas_upshifts" /id="D956" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="1.08869" /MaxDrop="5.39832" /score="24.3759796" /energy="-9.3" /TU="NA" /idTUdmin="U1409" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1686914..1688098) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /EC_number="5.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10348844, 18399999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10348844, 18399999; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine racemase (minor activity)" /protein_id="NP_389646.1" /db_xref="EnsemblGenomes-Gn:BSU17640" /db_xref="EnsemblGenomes-Tr:CAB13648" /db_xref="GOA:P94494" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="PDB:5IRP" /db_xref="SubtiList:BG12267" /db_xref="UniProtKB/Swiss-Prot:P94494" /translation="MIKLCREVWIEVNLDAVKKNLRAIRRHIPHKSKIMAVVKANGYG HGSIEVARHALEHGASELAVASVEEGIVLRKAGITAPILVLGFTSLSCVKKSAAWNIT LSAFQVDWMKEANEILEKEASANRLAIHINVDTGMGRLGVRTKEELLEVVKALKASKF LRWTGIFTHFSTADEPDTTLTKLQHEKFISFLSFLKKQGIELPTVHMCNTAAAIAFPE FSADMIRLGIGLYGLYPSAYIKQLNLVKLEPALSLKARIAYVKTMRTEPRTVSYGATY IAEPNEVIATLPIGYADGYSRALSNRGFVLHRGKRVPVAGRVTMDMIMVSLGENGEGK QGDEVVIYGKQKGAEISVDEVAEMLNTINYEVVSTLSRRIPRFYIRDGEIFKVSTPVL YV*" /label="alrB CDS" gene complement(1686914..1688098) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /label="alrB gene" S_feature complement(1688099..1688178) /Source="Nicolas_S_feature" /locus_tag="new_1899126_1899205_c" /HighExp="S4, S5, S3, S6, S7, B36, BT, S8, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.908" /TUlongSig="NA" /TUlongPSig="NA" /label="S638" promotor_-10 complement(1688171..1688189) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1688182) /Source="Nicolas_upshifts" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1688205..1688210) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1688490..1688497 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1688512..1688531 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1688520 /Source="Nicolas_upshifts" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1688562..1689023 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative prophage protein" /protein_id="NP_389648.2" /db_xref="EnsemblGenomes-Gn:BSU17650" /db_xref="EnsemblGenomes-Tr:CAB13649" /db_xref="InterPro:IPR020216" /db_xref="SubtiList:BG12268" /db_xref="UniProtKB/Swiss-Prot:P94495" /translation="MNRGVSFQIPNEYGNFLWRILQPVEIANYRWQTSGESYFVVEGE LDDEELFHDYEIVEGAVFEQQLKTNQYYTIFVELKAFPYGKMVNQVNTYEEFADSDCE LVLLIADNSYVSIYCKNKNIIEKLYFNALQHDFEDVQFITDENDTRTSLTV*" /label="yncE CDS" gene 1688562..1689023 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /label="yncE gene" CDS 1689053..1689487 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /EC_number="3.6.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11375514, 15939294, 16908222, 17169987, 21358047, 23897460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11375514, 15939294, 16908222, 17169987, 21358047, 23897460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="deoxyuridine 5'-triphosphate pyrophosphatase (phage origin)" /protein_id="NP_389649.1" /db_xref="EnsemblGenomes-Gn:BSU17660" /db_xref="EnsemblGenomes-Tr:CAB13650" /db_xref="GOA:O31801" /db_xref="InterPro:IPR029054" /db_xref="InterPro:IPR033704" /db_xref="InterPro:IPR036157" /db_xref="PDB:2XCD" /db_xref="PDB:2XCE" /db_xref="PDB:4AOO" /db_xref="PDB:4AOZ" /db_xref="PDB:4APZ" /db_xref="PDB:4B0H" /db_xref="SubtiList:BG13437" /db_xref="UniProtKB/Swiss-Prot:O31801" /translation="MTMQIKIKYLDETQTRISKIEQGDWIDLRAAEDVTIKKDEFKLV PLGVAMELPEGYEAHVVPRSSTYKNFGVIQTNSMGVIDESYKGDNDFWFFPAYALRDT EIKKGDRICQFRIMKKMPAVELVEVEHLGNEDRGGLGSTGTK*" /label="dutA CDS" gene 1689053..1689487 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /label="dutA gene" S_feature complement(1689236..1689541) /Source="Nicolas_S_feature" /locus_tag="new_1900263_1900568_c" /HighExp="LoTm, S5, T5.0H, S8, T4.0H, S4, S7, T3.30H, Cold, T-4.40H" /AntisenseName="yncF" /AntisenseCor="-0.40042805081531202" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S639" downshifts 1689334 /Source="Nicolas_upshifts" /id="D957" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.18195" /MaxDrop="2.2821" /score="0.171090809" /energy="-9.3" /TU="U1410" /idTUdmin="U1408" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" S_feature 1689488..1690584 /Source="Nicolas_S_feature" /locus_tag="new_1900515_1901611" /HighExp="S8, G150, G180, dia0, G135, UNK1, MG 15, Lbexp, Fru, S7" /AntisenseName="cotU" /AntisenseCor="-0.266961200384908" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S640" S_feature complement(1689543..1689828) /Source="Nicolas_S_feature" /locus_tag="new_1900570_1900855_c" /HighExp="LoTm, dia5, dia15, T3.30H, T3.0H, T-4.40H, T4.0H, T5.0H, T-3.40H, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25207000000000002" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S641" downshifts complement(1689586) /Source="Nicolas_upshifts" /id="D958" /incds=0 /nref=2 /ntot=95 /MaxReadThrough="4.29622" /MaxDrop="2.9464" /score="11.6697365" /energy="-9.7" /TU="U1411" /idTUdmin="U1411" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1689823..1689842) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1689828) /Source="Nicolas_upshifts" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1689854..1689859) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1690090) /Source="Nicolas_upshifts" /id="D959" /incds=0 /nref=17 /ntot=130 /MaxReadThrough="2.07509" /MaxDrop="8.56023" /score="11.6697365" /energy="-9.7" /TU="NA" /idTUdmin="U1412" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1690090..1690350) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12562816, 18065538, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 18065538, 20023017; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389650.1" /db_xref="EnsemblGenomes-Gn:BSU17670" /db_xref="EnsemblGenomes-Tr:CAB13651" /db_xref="GOA:O31802" /db_xref="SubtiList:BG13471" /db_xref="UniProtKB/Swiss-Prot:O31802" /translation="MGYYKKYKEEYYTWKKTYYKKYYDNDKKHYDCDKYYDHDKKHYD YDKKYDDHDKKYYDDHDYHYEKKYYDDDDHYYDFVESYKKHH*" /label="cotU CDS" gene complement(1690090..1690350) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /label="cotU gene" promotor_-10 complement(1690371..1690390) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1690381) /Source="Nicolas_upshifts" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1690403..1690412) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1690585..1690710 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein (putative phage origin)" /db_xref="PSEUDO:CAX52624.1" /translation="MNVMVKIQELYDVIFHTAFEGFRVRHQKQTAKPARNRSYKE*" /label="ynzJ CDS" gene 1690585..1690710 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /pseudo /label="ynzJ gene" S_feature 1690711..1690827 /Source="Nicolas_S_feature" /locus_tag="new_1901738_1901854" /HighExp="G180, G135, G150, dia0, UNK1, S8, Lbexp, C90, MG 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S642" CDS 1690754..1690918 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein from phage origin" /protein_id="YP_009513957.1" /translation="MKLERIYFKESPIAHGQMTIDIEVKYNALNQKKLLEDLMCLDNF QFGIHKHLTI*" /label="conserved hypothetical protein from phage origin CDS" gene 1690754..1690918 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /label="gene" promotor_-35 1690802..1690811 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1690825..1690844 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1690829..1691139 /Source="Nicolas_S_feature" /locus_tag="new_1901856_1902166" /HighExp="S7, S6, S8, S5, BT, G/S, Pyr, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.585202" /TUshortSig="SigK, SigA" /TUshortPSig="0.935, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S643" upshifts 1690829 /Source="Nicolas_upshifts" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1691120..1691127 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1691141..1691160 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1691141 /Source="Nicolas_upshifts" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1691192..1692031 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:416889, 418407, 9648749, 10091656, 10574451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 416889, 418407, 9648749, 10091656, 10574451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase A (phage origin)" /protein_id="NP_389651.1" /db_xref="EnsemblGenomes-Gn:BSU17680" /db_xref="EnsemblGenomes-Tr:CAB13652" /db_xref="GOA:P0CI79" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="PDB:1B02" /db_xref="PDB:1BKO" /db_xref="PDB:1BKP" /db_xref="PDB:1BSF" /db_xref="PDB:1BSP" /db_xref="SubtiList:BG11190" /db_xref="UniProtKB/Swiss-Prot:P0CI79" /translation="MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVI SKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDG TIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTP CVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNI GDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFE VAV*" /label="thyA CDS" gene 1691192..1692031 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /label="thyA gene" promotor_-10 complement(1691214..1691233) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1691235) /Source="Nicolas_upshifts" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1691248..1691251) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1691991 /Source="Nicolas_upshifts" /id="D960" /incds=0 /nref=6 /ntot=143 /MaxReadThrough="4.34299" /MaxDrop="3.3234" /score="1.39203037" /energy="-7.7" /TU="U1410,U1414" /idTUdmin="U1413" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts complement(1692137) /Source="Nicolas_upshifts" /id="D961" /incds=0 /nref=6 /ntot=150 /MaxReadThrough="3.28185" /MaxDrop="3.73135" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1417" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature complement(1692138..1692444) /Source="Nicolas_S_feature" /locus_tag="new_1903165_1903471_c" /HighExp="LBGstat, Lbstat, LoTm, B60, LPhT, M9-stat, T1.30H, B36, nit, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99924299999999999" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S644" CDS complement(1692154..1692441) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513958.1" /translation="MEHTGHSSFLQLFCLNLTLIRVEIGMKYEKTSLFGMILVIVALL ISIYFMCNTNALIPAGYDLAIHGIVISRTVMIAFTLYLVSKLGYFLLNKKD*" /label="conserved protein of unknown function CDS" gene complement(1692154..1692441) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /label="gene" downshifts complement(1692181) /Source="Nicolas_upshifts" /id="D962" /incds=0 /nref=2 /ntot=85 /MaxReadThrough="3.82042" /MaxDrop="6.47995" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1418" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1692268..1692276 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1692290..1692309 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1692292 /Source="Nicolas_upshifts" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="upshifts" S_feature 1692303..1692463 /Source="Nicolas_S_feature" /locus_tag="new_1903330_1903490" /HighExp="S8, S6, S7, BT, S5, S4, S3, Pyr, G/S, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S645" downshifts 1692435 /Source="Nicolas_upshifts" /id="D963" /incds=0 /nref=13 /ntot=53 /MaxReadThrough="1.26429" /MaxDrop="5.75919" /score="7.35184753" /energy="-11.1" /TU="NA" /idTUdmin="U1416" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1692484..1693206) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_389652.2" /db_xref="EnsemblGenomes-Gn:BSU17690" /db_xref="EnsemblGenomes-Tr:CAB13653" /db_xref="GOA:O31803" /db_xref="InterPro:IPR029143" /db_xref="PDB:4HFS" /db_xref="SubtiList:BG13438" /db_xref="UniProtKB/Swiss-Prot:O31803" /translation="MVKKVLIAGAVGTAVLFGTLSSGIPGLPAADAQVAKAASELPNG IGGRVYLNSTGAVFTAKIVLPETVKNNDSVSTPYIYSGFRATSGTEADIGLQYSKQYN VWKPLMKVGSKNEETYIEGKDKFTYNKGFRPGSTVQMTIYKNLSGNTRMTLWGTNNDG YTGRIITEIQGTNIGTISKWKTLATAAVSYESQRDAIKATFSTSFNNITIDNKAVTPV VDTQDFAKVSVAGNNVTISVNK*" /label="yncM CDS" gene complement(1692484..1693206) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /label="yncM gene" downshifts complement(1692489) /Source="Nicolas_upshifts" /id="D964" /incds=0 /nref=31 /ntot=133 /MaxReadThrough="5.62856" /MaxDrop="4.3658" /score="0.425084384" /energy="-11.1" /TU="U1417" /idTUdmin="U1418" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1693231..1693250) /Source="Nicolas_upshift_promotors" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1693239) /Source="Nicolas_upshifts" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1693241..1693365) /Source="Nicolas_S_feature" /locus_tag="new_1904268_1904392_c" /HighExp="H2O2, dia15, S8, G180, G150, Paraq, Oxctl, LBGstat, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S646" CDS complement(1693366..1693722) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function (phage origin)" /protein_id="YP_003097731.1" /db_xref="EnsemblGenomes-Gn:BSU17699" /db_xref="EnsemblGenomes-Tr:CAX52625" /db_xref="GOA:C0H417" /db_xref="InterPro:IPR025621" /db_xref="UniProtKB/Swiss-Prot:C0H417" /translation="MYRNIVFYLILLCLFISVVMKSFEVIRTIANVICFIFVLLYFKD EMKTYSRKALAILSICFLFLVGICAFIILQGQTLMKRHLFFTGLETIAGILLIIVSLS ICTFILRKISNRLKRM*" /label="ynzK CDS" gene complement(1693366..1693722) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /label="ynzK gene" promotor_-10 complement(1693746..1693765) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1693763) /Source="Nicolas_upshifts" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1693781..1693785) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1693962) /Source="Nicolas_upshifts" /id="D965" /incds=0 /nref=58 /ntot=194 /MaxReadThrough="0.902090000000001" /MaxDrop="9.00312" /score="34.0680178" /energy="-10.8" /TU="NA" /idTUdmin="U1419" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1693968..1694168) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389653.2" /db_xref="EnsemblGenomes-Gn:BSU17700" /db_xref="EnsemblGenomes-Tr:CAB13654" /db_xref="GOA:P07790" /db_xref="SubtiList:BG10492" /db_xref="UniProtKB/Swiss-Prot:P07790" /translation="MGYYKKYKEEYYTVKKTYYKKYYEYDKKDYDCDYDKKYDDYDKK YYDHDKKDYDYVVEYKKHKKHY*" /label="cotC CDS" gene complement(1693968..1694168) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /label="cotC gene" downshifts 1694151 /Source="Nicolas_upshifts" /id="D966" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="1.37504" /MaxDrop="5.08099" /score="-4.2739983" /energy="-8" /TU="NA" /idTUdmin="U1416" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1694190..1694209) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1694202) /Source="Nicolas_upshifts" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1694222..1694231) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1694343..1694531) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10974125, 11007775, 26239117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974125, 11007775, 26239117; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_389654.1" /db_xref="EnsemblGenomes-Gn:BSU17710" /db_xref="EnsemblGenomes-Tr:CAB13655" /db_xref="GOA:O31804" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG13464" /db_xref="UniProtKB/Swiss-Prot:O31804" /translation="MELSFTKILVILFVGFLVFGPDKLPALGRAAGKALSEFKQATSG LTQDIRKNDSENKEDKQM*" /label="tatAC CDS" gene complement(1694343..1694531) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /label="tatAC gene" downshifts complement(1694359) /Source="Nicolas_upshifts" /id="D967" /incds=0 /nref=213 /ntot=254 /MaxReadThrough="3.38696" /MaxDrop="6.07983" /score="8.58114058" /energy="-11" /TU="U1420,U1421" /idTUdmin="U1420" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" misc_feature complement(1694500..1694507) /Source="Nicolas_upshift_promotors" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1694513) /Source="Nicolas_upshifts" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1694560..1694579) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1694578) /Source="Nicolas_upshifts" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1694594..1694601) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1694610..1694747 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513959.1" /translation="MNILKPAQRRIHKTAAAEYNVQCHLPKKQEAGWINYVALPEMIQ T*" /label="hypothetical protein CDS" gene 1694610..1694747 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /label="gene" promotor_-35 1694641..1694646 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1694661..1694679 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1694679..1694781 /Source="Nicolas_S_feature" /locus_tag="new_1905706_1905808" /HighExp="S3, S4, LoTm, BT, B36, S5, S7, S6, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.35884500000000003" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S647" upshifts 1694679 /Source="Nicolas_upshifts" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="upshifts" CDS 1694782..1695180 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein of unknown function" /protein_id="NP_389655.1" /db_xref="EnsemblGenomes-Gn:BSU17720" /db_xref="EnsemblGenomes-Tr:CAB13656" /db_xref="SubtiList:BG13439" /db_xref="UniProtKB/Swiss-Prot:O31805" /translation="MRFTKVVGFLSVLGLAAVFPLTAQAEKAGTAGAGEWDKLGTYTY TYSSPTVYSTGGDFRVCLSGSTPFSVSLHLYEDDPGDNPDDYVGANYFSPGECHTFGS IGKFVDGSNNKAEFFVTDYSGKSKTVTFYD*" /label="yndA CDS" gene 1694782..1695180 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /label="yndA gene" S_feature 1695181..1695985 /Source="Nicolas_S_feature" /locus_tag="new_1906208_1907012" /HighExp="LoTm, S3, BT, S4, B36, S6, S5, S7, S8, T5.0H" /AntisenseName="yndB" /AntisenseCor="-0.559713635360228" /AntisenseRegPval="-22.9" /CDS_PredictionProba="0.91098199999999996" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S648" CDS complement(1695245..1695679) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /experiment="publication(s) with functional evidences, PMID:20818668, 28160315" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20818668, 28160315; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of stress-related ATPase (flavonoid-sensing)" /protein_id="NP_389656.1" /db_xref="EnsemblGenomes-Gn:BSU17730" /db_xref="EnsemblGenomes-Tr:CAB13657" /db_xref="GOA:O31806" /db_xref="InterPro:IPR013538" /db_xref="InterPro:IPR023393" /db_xref="PDB:2KEW" /db_xref="PDB:2KTE" /db_xref="SubtiList:BG13440" /db_xref="UniProtKB/Swiss-Prot:O31806" /translation="MAQNNENALPDITKSITLEAPIQKVWETVSTSEGIAKWFMPNDF QLKEGQEFHLQSPFGPSPCKVLAVQAPTELSFEWDTEGWVVTFQLEDLGEKTGFTLIH SGWKEPNEVIGKANEKSSVVRGKMDGGWTGIVNERLRKAVEE*" /label="flvS CDS" gene complement(1695245..1695679) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /label="flvS gene" downshifts complement(1695261) /Source="Nicolas_upshifts" /id="D968" /incds=0 /nref=213 /ntot=253 /MaxReadThrough="1.7995" /MaxDrop="6.63594" /score="29.1580701" /energy="-7" /TU="NA" /idTUdmin="U1423" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1695709..1695728) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1695725) /Source="Nicolas_upshifts" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1695742..1695749) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1695986..1696174 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846" /codon_start=1 /transl_table=11 /product="conserved protein involved in spore germination" /protein_id="NP_389657.2" /db_xref="EnsemblGenomes-Gn:BSU17740" /db_xref="EnsemblGenomes-Tr:CAB13658" /db_xref="SubtiList:BG13465" /db_xref="UniProtKB/Swiss-Prot:O31807" /translation="MLGKIKAAIDNSPGKPARILVSEKAFQQLEEEMRFVYVSKPKTI MGIPVEVSDQAESFKLEF*" /label="ynzB CDS" gene 1695986..1696174 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /label="ynzB gene" S_feature 1696175..1696260 /Source="Nicolas_S_feature" /locus_tag="new_1907202_1907287" /HighExp="LoTm, BT, S4, S6, S3, S8, S7, B36, S5, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S649" downshifts 1696219 /Source="Nicolas_upshifts" /id="D969" /incds=0 /nref=7 /ntot=89 /MaxReadThrough="2.20002" /MaxDrop="4.21414" /score="19.5879917" /energy="-11.9" /TU="NA" /idTUdmin="U1422" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1696289..1696295 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1696307..1696466 /Source="Nicolas_S_feature" /locus_tag="new_1907334_1907493" /HighExp="S8, S4, S6, S7, S5, S3, BT, ferm, LoTm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.95681300000000002" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S650" upshifts 1696307 /Source="Nicolas_upshifts" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1696309..1696320 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1696467..1698029 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10762253, 27208128; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_389658.1" /db_xref="EnsemblGenomes-Gn:BSU17750" /db_xref="EnsemblGenomes-Tr:CAB13659" /db_xref="GOA:O31808" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG13441" /db_xref="UniProtKB/Swiss-Prot:O31808" /translation="MMRWRNNQYKTQKQHKSDYSTAEKQDQDVLTGNIGYDLEHVKRK IGHNGDVHFRELEITQLHVKAALIFVEGLSDQDLINKGLSVLVMNQPNQVSDEISQSG KGILTSKQIKNQIVSIGDVIDSEKISDIVLNVFMGSTALLIDGIPQAFLLGTVKKQNR SIEEPLSEALVRGPRTGFTEELSTNTALLRQQGKNDQLTLQRFEVGTRLKKDLIIAYM NDIADPKVVEEVRKRVRGIEIDHLPESGYVEQLIEDNYLSPFPQVQSTERPDRVISGL MEGRVAILLDGTPFALIVPVTFSMMLQSPEDYYERWFPSSLIRLLRFIAAMITLFAPA LYISFISFHPGLIPTKLAISISGTRQGVPFPSLIEALFMEVAIEILREAGLRLPKPIG PAIGIVGGLIIGEAAVQAGIVSPIMVIVVALTAISSFAIPHYSTGIALRMLRFGAMFC AAVFGLFGVIMYYLLLSSHVVKLKSFGVPYASPAVPYHLKDWKDFVIRMPLLVMKRRP KMMNTDNTKRVK*" /label="yndD CDS" gene 1696467..1698029 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /label="yndD gene" promotor_-10 complement(1696770..1696789) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1696779) /Source="Nicolas_upshifts" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1696804..1696811) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1698059..1699150 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane protein" /protein_id="NP_389659.1" /db_xref="EnsemblGenomes-Gn:BSU17760" /db_xref="EnsemblGenomes-Tr:CAB13660" /db_xref="GOA:O31809" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG13442" /db_xref="UniProtKB/Swiss-Prot:O31809" /translation="MFSPTSKITTAQATIIIINYMLAAGVLTLPRTVTEQTQSPDGWI SVLLGGVLAVIAGMIIAKLSQQYPKETFYEYSRHIVGKWLGHLISIVFITYFLALGAF EVRVMSEIVDFFLLEGTPSWAIIMTVLWIGLYSITQGLDPIARLFEMIFPITVIIFLT IALMSLGIFEINNLRPVLGDGIMPVLRGVKTTNLSFTCSEIMFILVAFMKKPKNAVKA VVIGTGVVTSFYMITMIMVIGALSVEGVVTRTWPGLDLMRSFEIPGLIFERFESFLLV IWIMQLFATFIITFYAASLGVSQVFKKKPLSCMFGLLPVIYILSCMPKNENDVFILGD TVSHIALYIFGALPILLLVISKWRKRGEK*" /label="yndE CDS" gene 1698059..1699150 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /label="yndE gene" CDS 1699140..1700354 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 27208128; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative spore germination lipoprotein" /protein_id="NP_389660.1" /db_xref="EnsemblGenomes-Gn:BSU17770" /db_xref="EnsemblGenomes-Tr:CAB13661" /db_xref="GOA:O31810" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG13443" /db_xref="UniProtKB/Swiss-Prot:O31810" /translation="MKSKLKRQLPAMVIVCLLMICVTGCWSSREIEDLGLTFAIAIDK GKETNTEKELKEEGGSYPKKDNITLTYQFVNEKAAGAGTSGGGGSGQGAQKAYINISE TGDSLQQIGSEVALRRDREVFSPHLKVVVMSEDVLHTFPIDEMLDQFFRDNEIRLSCL VLSAKGEARDALQLKENGEIPAFRLIGLGENEHKVSRILPPMTLAKLIGKLHSGSSFL LQNVVAANGAVKYSGAAVINGKSKKMIGTLNEYETEGITWIRGEGKGGVVKSHDKKSQ QTLAYDINKIKSRIQPIVKGKDISFHVDIESEGDLVENWNTKEALDTQFIDRLETTIE NEVKKIVGQVLKKIQHDYKADVAGFDESFRLTYPHLWKRVKNNWDDTFSKADITYSVN VTITHFGTVKTQ*" /label="yndF CDS" gene 1699140..1700354 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /label="yndF gene" promotor_-35 1700432..1700439 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1700454..1700473 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1700465 /Source="Nicolas_upshifts" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="upshifts" CDS 1700501..1701307 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11737947, 22333191, 27435445" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389661.1" /db_xref="EnsemblGenomes-Gn:BSU17780" /db_xref="EnsemblGenomes-Tr:CAB13662" /db_xref="GOA:O31811" /db_xref="SubtiList:BG13444" /db_xref="UniProtKB/Swiss-Prot:O31811" /translation="MRQKPIYVEIEMKSDLDTLWEYTQNPSLHKEWDLRFSNITYLNS QPCEKQKFLYETRVGFGLKVSGTGETVGVFNKCSSERSSSLAFGSDHPLSLIRHGSGY WKYIQRENGKMTFLTQYQYKTAYGLLGRWIDRLLFRPLLGWATAWSFDALRLWVEQNK HPKRFIRSAIIYVFMCLFFSLFWFYQGFAGVKTSILTGTAEIGLAILWLLPLKRKWII HGVQACIFAGFACLGSEIFMWVLLSVFSAASGALSLQLPSARRTKRKRKK*" /label="yndG CDS" gene 1700501..1701307 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /label="yndG gene" S_feature complement(1701115..1702213) /Source="Nicolas_S_feature" /locus_tag="new_1912142_1913240_c" /HighExp="S8, S6, S7, S5, T0.30H, T2.0H, GM 150, BT, T1.30H, T-4.40H" /AntisenseName="yndH" /AntisenseCor="-0.58089150558713998" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S651" CDS 1701312..1701929 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389662.1" /db_xref="EnsemblGenomes-Gn:BSU17790" /db_xref="EnsemblGenomes-Tr:CAB13663" /db_xref="InterPro:IPR025311" /db_xref="SubtiList:BG13445" /db_xref="UniProtKB/Swiss-Prot:O31812" /translation="MSSIYEKSIINYHLLHPKLQKRYQLDGSHTFSGTGTMSEISGGS FLVRMLLKLGVFFRCFFSERGKDIPFTIQNRTCLLKSQHTGIEWNRTFFFKGKKRFFD ALMIYDEKENRILDFFGKPHLLLSVLTFEASLDGSLTITSGKQWLLICGKRIPLPKWL TGTSEVCETFDEKKNCFTIEVHVQNTILGTLFFYKGTFQEEERES*" /label="yndH CDS" gene 1701312..1701929 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /label="yndH gene" CDS 1701926..1703566 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618455, 15849754, 16850406, 28615734; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389663.1" /db_xref="EnsemblGenomes-Gn:BSU17800" /db_xref="EnsemblGenomes-Tr:CAB13664" /db_xref="GOA:O31813" /db_xref="InterPro:IPR025450" /db_xref="SubtiList:BG13446" /db_xref="UniProtKB/Swiss-Prot:O31813" /translation="MKRNGIVSALCFIGFLAAEAPDISVAEALVLLSILFFVPGIFPF VFRQSPVRAAQFMENGLIQCYPVAAFFAVLALVTEVGGFALIWWMYTVFNALYAILRL WETKIHRIEETSVLFGLIYLAGGGFWFFAYAAHLQIMQFGPLIILLTAVHFHYSAFLI PIFNGLLGRTIRKHRMLYSWITWVILLSPLLIALGITYSKTLDVIAVSIYMAAIYLHA FLVFTAAFRTKTGTFLIRLSSAVLMITIAFSMIYSFGVFRQEVTLTINQMIWIHGFVN AFGVILPALIGWRIEDAKPFDADSVKTFSRIYGKRKIGEEFLANIQAENNARYSGLVD DMGSLRSKDFSPEKLAPLILSFYEQTIEYNIKAKVTWSTWFRPLAIIYEWFSRRIGQI HLSTNPDWYRMYSKIKGVHSKKDGRERVRAWIRTNEKNETIFTALYSVYRSNGEGYMN ISLPLPFSSMTGILKPYHHQEKLVLTSRRRKSRAGDEGIYLQTRAGTCPLPLSETFLI EAVHDNKLTAVHHMWLFGIKFLTVHYSITHINQPIERT*" /label="yndJ CDS" gene 1701926..1703566 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /label="yndJ gene" promotor_-10 complement(1702200..1702219) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1702213) /Source="Nicolas_upshifts" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1702233..1702241) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1703206..1703972) /Source="Nicolas_S_feature" /locus_tag="new_1914233_1914999_c" /HighExp="T2.0H, T1.30H, T2.30H, GM 150, T3.30H, T1.0H, C30, T3.0H, T4.0H, T0.30H" /AntisenseName="yndK" /AntisenseCor="-0.33555507319526101" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S652" CDS 1703603..1703968 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage/plasmid replication protein" /protein_id="NP_389664.1" /db_xref="EnsemblGenomes-Gn:BSU17810" /db_xref="EnsemblGenomes-Tr:CAB13665" /db_xref="GOA:O31814" /db_xref="SubtiList:BG13447" /db_xref="UniProtKB/Swiss-Prot:O31814" /translation="MNCFKILHRIKTGKEGFMVFYISLFLILWLAAGFAVGMKQVYVD QLFDKAVIERLEKEANDHGHADRMIKQRVLYIAAVTVSGFISVYYEMKTIPQRRNIRK IEKNIMKLNQAKKRRMKRK*" /label="yndK CDS" gene 1703603..1703968 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /label="yndK gene" downshifts 1703945 /Source="Nicolas_upshifts" /id="D970" /incds=0 /nref=166 /ntot=243 /MaxReadThrough="2.62352" /MaxDrop="5.68917" /score="15.340233" /energy="-10.4" /TU="NA" /idTUdmin="U1426" /TUdmin=2226 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1703965..1704245) /gene="surA" /locus_tag="BSU_misc_RNA_72" /product="small untranslated RNA controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surA RNA" gene complement(1703965..1704245) /gene="surA" /locus_tag="BSU_misc_RNA_72" /label="surA gene" S_feature complement(1703974..1704105) /Source="Nicolas_S_feature" /locus_tag="new_1915001_1915132_c" /HighExp="B60, T2.0H, T1.30H, T1.0H, T2.30H, M9-stat, LoTm, S5, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.443, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S653" downshifts complement(1704017) /Source="Nicolas_upshifts" /id="D971" /incds=0 /nref=21 /ntot=129 /MaxReadThrough="4.91485" /MaxDrop="4.94426" /score="14.7738511" /energy="-10.4" /TU="U1429,U1431" /idTUdmin="U1429" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1704065..1704074 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1704087..1704096) /Source="Nicolas_upshift_promotors" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1704088..1704107 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1704093 /Source="Nicolas_upshifts" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" S_feature 1704095..1704193 /Source="Nicolas_S_feature" /locus_tag="new_1915122_1915220" /HighExp="S8, S6, S7, BT, S5, G/S, B36, C30, Pyr, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52117199999999997" /TUshortSig="SigK" /TUshortPSig="0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S654" upshifts complement(1704105) /Source="Nicolas_upshifts" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1704107..1704237) /Source="Nicolas_S_feature" /locus_tag="new_1915134_1915264_c" /HighExp="T2.0H, T1.30H, M9-stat, T2.30H, T1.0H, B60, LoTm, T4.0H, T3.30H, T0.30H" /AntisenseName="yndL" /AntisenseCor="0.22331158442510801" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S655" CDS 1704194..1704952 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /EC_number="3.4.19.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26158264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage gamma-polyglutamate hydrolase" /protein_id="NP_389665.1" /db_xref="EnsemblGenomes-Gn:BSU17820" /db_xref="EnsemblGenomes-Tr:CAB13666" /db_xref="GOA:O31815" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13448" /db_xref="UniProtKB/Swiss-Prot:O31815" /translation="MKPAKVSLLRRLLHSLKHVDCNIAKRFPSTIKIVKLLMIFMVFT PISSIYAEDVYQNFEELKNNEDPSDYGVVTKETGSPVLVLAIHGGGIEGGTSEVAREL SKEYSMYLFEGLKSAGNSVLHITSTHFDEPRALKMTGNHEYVISLHGYAEEDQQIEVG GTDRVRAADLVEKLQHAGFPAVLLNMDHPHAGVSPNNIANKSKTGLSIQIEMSTGFRK SLFGIFSLKSRAVTQNERFYEFTEVMFRFLKNSY*" /label="pghL CDS" gene 1704194..1704952 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /label="pghL gene" upshifts 1704227 /Source="Nicolas_upshifts" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1704243..1704262) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1704244) /Source="Nicolas_upshifts" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1704277..1704284) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1704767..1704978) /Source="Nicolas_S_feature" /locus_tag="new_1915794_1916005_c" /HighExp="S8, S5, S7, S6, S4, ferm, nit, BT, Pyr, G/S" /AntisenseName="yndL" /AntisenseCor="0.82198535504067005" /AntisenseRegPval="-66.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.515" /TUlongSig="NA" /TUlongPSig="NA" /label="S656" downshifts 1704931 /Source="Nicolas_upshifts" /id="D972" /incds=0 /nref=3 /ntot=23 /MaxReadThrough="4.17889" /MaxDrop="5.0493" /score="15.340233" /energy="-10.4" /TU="U1428,U1430" /idTUdmin="U1428" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" S_feature 1704976..1705595 /Source="Nicolas_S_feature" /locus_tag="new_1916003_1916622" /HighExp="S8, S6, S7, S5, C30, BT, G135, LBGstat, GM 150, M/G" /AntisenseName="yndM" /AntisenseCor="0.75549671487088998" /AntisenseRegPval="-50.2" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S657" CDS complement(1704979..1705518) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389666.1" /db_xref="EnsemblGenomes-Gn:BSU17830" /db_xref="EnsemblGenomes-Tr:CAB13667" /db_xref="GOA:O31816" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG13449" /db_xref="UniProtKB/Swiss-Prot:O31816" /translation="MTIMNGFELHYLSFVYAQEFSSKNNNLGGQMKHIIALASKIAFT LALLYVILDRVYHASFLSVMFIALFLGFVSYLSGDMLVLPRTNNITASLADFGLSFVI LWVFVLTQTRNDFSPFGAALLSAACLTVFEYFFHRYLLKNVLDENFRNELSARDNTLQ YQTEAADELFPETKEKHKE*" /label="yndM CDS" gene complement(1704979..1705518) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /label="yndM gene" promotor_-10 complement(1705519..1705533) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1705525) /Source="Nicolas_upshifts" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1705547..1705553) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1705573..1705582 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1705595..1705610 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1705597 /Source="Nicolas_upshifts" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" CDS 1705636..1706070 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /EC_number="2.5.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11244082, 16399398, 19763274, 23256780" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244082, 16399398, 19763274, 23256780; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="magnesium-dependent bacillithiol-transferase" /protein_id="NP_389667.1" /db_xref="EnsemblGenomes-Gn:BSU17840" /db_xref="EnsemblGenomes-Tr:CAB13668" /db_xref="GOA:O31817" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR022858" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13450" /db_xref="UniProtKB/Swiss-Prot:O31817" /translation="MEIKGINHLLFSVSHLDTSIDFYQKVFGAKLLVKGRTTAYFDMN GIWLALNEEPDIPRNDIKLSYTHIAFTIEDHEFEEMSAKLKRLHVNILPGRERDERDR KSIYFTDPDGHKFEFHTGTLQDRLRYYKQEKTHMHFYDETAF*" /label="fosB CDS" gene 1705636..1706070 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /label="fosB gene" CDS 1705928..1706275 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27144405" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513960.1" /translation="MNAIENQFILPTLTATNLNFIPEPFKTGFDITNKKKRICTFMMK RPFDSTTIFHIRLNLKKGVGGDFMFGEGFYPTCSTMPYLLNCTSDWVKVKLKYTLHYI LYEESELFYQMLN*" /label="yzzP CDS" gene 1705928..1706275 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /label="yzzP gene" S_feature 1706071..1706403 /Source="Nicolas_S_feature" /locus_tag="new_1917098_1917430" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T0.0H, T-1.10H, T2.30H, Salt, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.66836499999999999" /TUshortSig="SigWXY, Sig-, SigK" /TUshortPSig="1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S658" promotor_-35 1706362..1706371 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1706383..1706398 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1706405..1706583 /Source="Nicolas_S_feature" /locus_tag="new_1917432_1917610" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T-1.10H, T0.0H, T2.30H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigWXY, Sig-, SigK" /TUshortPSig="0.99, 1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S659" upshifts 1706405 /Source="Nicolas_upshifts" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1706474..1706553 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /product="putative conserved small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="ncrF RNA" gene 1706474..1706553 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /label="ncrF gene" downshifts 1706540 /Source="Nicolas_upshifts" /id="D973" /incds=0 /nref=16 /ntot=188 /MaxReadThrough="2.99425" /MaxDrop="4.30173" /score="-1.31226475" /energy="-14.3" /TU="U1433" /idTUdmin="U1434" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1706612..1707229) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the SOS regulon" /protein_id="NP_389668.1" /db_xref="EnsemblGenomes-Gn:BSU17850" /db_xref="EnsemblGenomes-Tr:CAB13669" /db_xref="GOA:P31080" /db_xref="InterPro:IPR006197" /db_xref="InterPro:IPR006199" /db_xref="InterPro:IPR006200" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10678" /db_xref="UniProtKB/Swiss-Prot:P31080" /translation="MTKLSKRQLDILRFIKAEVKSKGYPPSVREIGEAVGLASSSTVH GHLARLETKGLIRRDPTKPRAIEILDEEVDIPQSQVVNVPVIGKVTAGSPITAVENIE EYFPLPDRMVPPDEHVFMLEIMGDSMIDAGILDKDYVIVKQQNTANNGEIVVAMTEDD EATVKRFYKEDTHIRLQPENPTMEPIILQNVSILGKVIGVFRTVH*" /label="lexA CDS" gene complement(1706612..1707229) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /label="lexA gene" downshifts complement(1706613) /Source="Nicolas_upshifts" /id="D974" /incds=0 /nref=186 /ntot=254 /MaxReadThrough="2.74616" /MaxDrop="7.90985" /score="8.16083322" /energy="-16.3" /TU="U1435" /idTUdmin="U1435" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1707253..1707272) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1707274) /Source="Nicolas_upshifts" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1707286..1707293) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1707309..1707316 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1707328 /Source="Nicolas_upshifts" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1707330..1707349 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1707379..1707696 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12581363, 16267290, 16549676, 20400548, 20807205, 23728628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12581363, 16267290, 16549676, 20400548, 20807205, 23728628; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="NP_389669.1" /db_xref="EnsemblGenomes-Gn:BSU17860" /db_xref="EnsemblGenomes-Tr:CAB13670" /db_xref="GOA:Q45056" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR022887" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11820" /db_xref="UniProtKB/Swiss-Prot:Q45056" /translation="MIMSKESIIFVGLFTVILSAVILMLSYTSSGQELNQYVKIEVQQ GDTLWSIADQVADTKKINKNDFIEWVADKNQLQTSDIQPGDELVIPLKKKHQDAYELA TVR*" /label="dinK CDS" gene 1707379..1707696 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /label="dinK gene" promotor_-10 complement(1707396..1707414) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1707399) /Source="Nicolas_upshifts" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1707428..1707435) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1707715..1708368 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /function="16.9: Replicate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12581363, 16267290, 17020588, 19060143, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase, resolvase" /protein_id="NP_389670.1" /db_xref="EnsemblGenomes-Gn:BSU17870" /db_xref="EnsemblGenomes-Tr:CAB13671" /db_xref="GOA:Q45057" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG11821" /db_xref="UniProtKB/Swiss-Prot:Q45057" /translation="MKALIYARVSTNKEQQETSLKRQEEELTAIAAENGMEVVKVISE KASGYEMDRDGVFELLDEIKNADIDVILVQDETRLGRGNAKIALLHCIYREGVKVYTT AHRGELELSEADSMVLEIVSIVEEYQRKIHNMKIRRGMKRAVKNGFKPQKNLKNQHGN SGKEKIEVPISEIVRLRANKLTFAEIAATLRGFGYDVSKATVHRRFQEYIENEETAE* " /label="dinL CDS" gene 1707715..1708368 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /label="dinL gene" promotor_-35 1708371..1708378 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-35" promotor_-10 1708392..1708411 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-10" upshifts 1708405 /Source="Nicolas_upshifts" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="upshifts" CDS 1708432..1708665 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12581363, 16267290, 18431750,19306341, 22333191, 22933559, 23099262" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389671.1" /db_xref="EnsemblGenomes-Gn:BSU17880" /db_xref="EnsemblGenomes-Tr:CAB13672" /db_xref="GOA:O31818" /db_xref="InterPro:IPR009242" /db_xref="PDB:2HEP" /db_xref="PDB:2JVD" /db_xref="PDB:3BHP" /db_xref="SubtiList:BG13466" /db_xref="UniProtKB/Swiss-Prot:O31818" /translation="MISNAKIARINELAAKAKAGVITEEEKAEQQKLRQEYLKGFRSS MKNTLKSVKIIDPEGNDVTPEKLKREQRNNKLH*" /label="ynzC CDS" gene 1708432..1708665 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /label="ynzC gene" S_feature 1708666..1708801 /Source="Nicolas_S_feature" /locus_tag="new_1919693_1919828" /HighExp="M40t90, M40t45, dia15, C90, Etha, H2O2, T5.0H, Salt, dia5, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S660" promotor_-35 1708769..1708776 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-35" promotor_-10 1708790..1708809 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-10" upshifts 1708803 /Source="Nicolas_upshifts" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="upshifts" CDS 1708834..1710837 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /EC_number="2.2.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696621, 12682299, 12882400, 27739585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696621, 12682299, 12882400, 27739585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transketolase" /protein_id="NP_389672.1" /db_xref="EnsemblGenomes-Gn:BSU17890" /db_xref="EnsemblGenomes-Tr:CAB13673" /db_xref="GOA:P45694" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005478" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033247" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11247" /db_xref="UniProtKB/Swiss-Prot:P45694" /translation="MDTIEKKSVATIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTK FMNVSPANPGWFNRDRFVLSAGHGSALLYSMLHLSGFDLSIEDLKGFRQWGSKTPGHP EFGHTAGVDATTGPLGQGIAMAVGMAIAERHLAETYNRDSFNVVDHYTYSICGDGDLM EGISSEAASLAGHLQLGRLIVLYDSNDISLDGDLDRSFSENVKQRFEAMNWEVLYVED GNNIEELTAAIEKARQNEKKPTLIEVKTTIGFGSPNRAGTSGVHGAPLGKEESKLTKE AYAWTYEEDFYVPSEVYEHFAVAVKESGEKKEQEWNAQFAKYKEVYPELAEQLELAIK GELPKDWDQEVPVYEKGSSLASRASSGEVLNGLAKKIPFFVGGSADLAGSNKTTIKNA GDFTAVDYSGKNFWFGVREFAMGAALNGMALHGGLRVFGGTFFVFSDYLRPAIRLAAL MGLPVTYVFTHDSIAVGEDGPTHEPVEQLASLRAMPNLSLIRPADGNETAAAWKLAVQ STDHPTALVLTRQNLPTIDQTSEEALAGVEKGAYVVSKSKNETPDALLIASGSEVGLA IEAQAELAKENIDVSVVSMPSMDRFEKQSDEYKNEVLPADVKKRLAIEMGSSFGWGKY TGLEGDVLGIDRFGASAPGETIINEYGFSVPNVVNRVKALINK*" /label="tktA CDS" gene 1708834..1710837 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /label="tktA gene" misc_feature complement(1709038..1709057) /Source="Nicolas_upshift_promotors" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1709055) /Source="Nicolas_upshifts" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1710827 /Source="Nicolas_upshifts" /id="D975" /incds=0 /nref=230 /ntot=257 /MaxReadThrough="4.5478" /MaxDrop="6.66676" /score="16.4587041" /energy="-10.6" /TU="U1439" /idTUdmin="U1436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1710839..1711497) /Source="Nicolas_S_feature" /locus_tag="new_1921866_1922524_c" /HighExp="Lbstat, C30, Salt, BC, S7, LPhT, S8, M0t90, T-0.40H, Glucon" /AntisenseName="yneE" /AntisenseCor="4.3891878649396997E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.604, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S661" upshifts 1710937 /Source="Nicolas_upshifts" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="upshifts" misc_feature 1710938..1710957 /Source="Nicolas_upshift_promotors" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1710990..1711436 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /experiment="publication(s) with functional evidences, PMID:19682252, 25041308, 22720735, 27489185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682252, 25041308, 22720735, 27489185; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor controlling DNA replication" /protein_id="NP_389673.1" /db_xref="EnsemblGenomes-Gn:BSU17900" /db_xref="EnsemblGenomes-Tr:CAB13674" /db_xref="GOA:P45707" /db_xref="InterPro:IPR019683" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG11248" /db_xref="UniProtKB/Swiss-Prot:P45707" /translation="MERHYYTYLIKEEFANHYFGRESVMFELFQDYHWTSLEKQQYEM TEKQIQYITQPIPILHMHQRLKMNLNKTDYRQLDYIYRIALPKAKGHATFMMKEHMIE IVASGDYEAETIFFEVLRKVSPCFLAMDFNSKRYGWLNPVKERNFV*" /label="pcfA CDS" gene 1710990..1711436 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /label="pcfA gene" misc_feature 1711460..1711479 /Source="Nicolas_upshift_promotors" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1711468 /Source="Nicolas_upshifts" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1711479..1711496) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1711497) /Source="Nicolas_upshifts" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1711515..1711519) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1711522..1711740 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389674.1" /db_xref="EnsemblGenomes-Gn:BSU17910" /db_xref="EnsemblGenomes-Tr:CAB13675" /db_xref="GOA:P45708" /db_xref="InterPro:IPR005359" /db_xref="SubtiList:BG11249" /db_xref="UniProtKB/Swiss-Prot:P45708" /translation="MTLWVGILVGVVALLIGVALGFFIARKYMMSYLKKNPPINEQML RMMMMQMGMKPSQKKINQMMKAMNNQTK*" /label="yneF CDS" gene 1711522..1711740 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /label="yneF gene" downshifts 1711752 /Source="Nicolas_upshifts" /id="D976" /incds=0 /nref=243 /ntot=260 /MaxReadThrough="3.51446" /MaxDrop="7.54782" /score="0.133420982" /energy="-4.3" /TU="U1441,U1442" /idTUdmin="U1439" /TUdmin=287 /isTUend="FALSE" /label="downshifts" S_feature 1711797..1712096 /Source="Nicolas_S_feature" /locus_tag="new_1922824_1923123" /HighExp="S4, S3, S5, G180, S8, T5.0H, LoTm, G135, S6, S7" /AntisenseName="ynzD" /AntisenseCor="-0.33023056016157298" /AntisenseRegPval="-7.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S662" CDS complement(1711814..1711987) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 15187183, 17350627, 22303282, 23378509, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 15187183, 17350627, 22303282, 23378509, 27965289; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase" /protein_id="NP_389675.1" /db_xref="EnsemblGenomes-Gn:BSU17920" /db_xref="EnsemblGenomes-Tr:CAB13676" /db_xref="GOA:O31819" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13467" /db_xref="UniProtKB/Swiss-Prot:O31819" /translation="MIREHLLKEIEKKRAELLQIVMANGMTSHITIELSQELDHLLIQ YQKQRLRAVAGDE*" /label="spo0D CDS" gene complement(1711814..1711987) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /label="spo0D gene" downshifts complement(1711827) /Source="Nicolas_upshifts" /id="D977" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="4.0851" /MaxDrop="5.22565" /score="1.92055758" /energy="-4.3" /TU="U1444,U1446" /idTUdmin="U1444" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1712025..1712044) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1712032) /Source="Nicolas_upshifts" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1712058..1712065) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1712067..1712075 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1712087..1712106) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1712087..1712105 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1712098..1712206 /Source="Nicolas_S_feature" /locus_tag="new_1923125_1923233" /HighExp="T4.0H, T3.30H, T3.0H, S2, Lbstat, T5.0H, T2.30H, S4, T-1.40H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA, SigA" /TUshortPSig="0.999, 1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S663" upshifts 1712098 /Source="Nicolas_upshifts" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1712099) /Source="Nicolas_upshifts" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1712121..1712128) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1712207..1712914 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /function="16.10: Respire" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16771673, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16771673, 16850406, 19682263; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome c-type biogenesis protein CcdA; thiol-disulfide oxido-reductase" /protein_id="NP_389676.1" /db_xref="EnsemblGenomes-Gn:BSU17930" /db_xref="EnsemblGenomes-Tr:CAB13677" /db_xref="GOA:P45706" /db_xref="InterPro:IPR003834" /db_xref="SubtiList:BG11240" /db_xref="UniProtKB/Swiss-Prot:P45706" /translation="MGDVNYFLTFGAGFLSFISPCCLPLYPAFLSYITGVSMDDVKTE KLLLQKRSLFHTLCFLLGFSVIFIALGYGTSFIGSLFRDYHDAIRQIGALLIILFGFI TLGVFRPEAMMKERRIHFKHKPSGFLGSVLIGMAFAAGWTPCTGPILAAVITLAGTNP GSAVPYMMLYVLGFAVPFLLLSFFITKLKWIRKNQLFIMKAGGVLMIVIGVLLFFNWM SLIIILLSDLFGGFTGF*" /label="ccdA CDS" gene 1712207..1712914 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /label="ccdA gene" promotor_-35 1712934..1712941 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1712953..1712972 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1712961 /Source="Nicolas_upshifts" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1713003..1713365 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative response regulator (CheY homolog)" /protein_id="NP_389677.1" /db_xref="EnsemblGenomes-Gn:BSU17940" /db_xref="EnsemblGenomes-Tr:CAB13678" /db_xref="GOA:P45709" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11250" /db_xref="UniProtKB/Swiss-Prot:P45709" /translation="MTRVLVVDDAKFMRVKIREILEEANYIIAGEAADGEQAADLYKK LRPDLVTMDITMPVKNGIKALRDILTFDPKAKVIMCTAMRQQRIVTEAIELGAKDFIV KPFEETKVLEAVSRVMGH*" /label="yneI CDS" gene 1713003..1713365 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /label="yneI gene" promotor_-35 1713383..1713386 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1713401..1713420 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1713412 /Source="Nicolas_upshifts" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1713444..1713935 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389678.1" /db_xref="EnsemblGenomes-Gn:BSU17950" /db_xref="EnsemblGenomes-Tr:CAB13679" /db_xref="GOA:P45710" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR031306" /db_xref="SubtiList:BG11251" /db_xref="UniProtKB/Swiss-Prot:P45710" /translation="MISMMIIVSSIIAVLMAVAVMVVRIKSSDKPVSPKKIILPPIFM STGALMFLFPVFWVTGAEFLEAFTLGVIFSIFLIKTSKFEIKNNEIYMKRSKAFVFIL VGLLVIRIVMKSILSTSIDYGALSGMFWILAFGMIVPWRIAMYLSYRKLHNELQSSNI QMN*" /label="yneJ CDS" gene 1713444..1713935 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /label="yneJ gene" downshifts 1713931 /Source="Nicolas_upshifts" /id="D978" /incds=0 /nref=110 /ntot=273 /MaxReadThrough="1.09905" /MaxDrop="5.9692" /score="16.4219082" /energy="-9.7" /TU="NA" /idTUdmin="U1445" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1713966..1714394) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DynA" /protein_id="NP_389679.1" /db_xref="EnsemblGenomes-Gn:BSU17960" /db_xref="EnsemblGenomes-Tr:CAB13680" /db_xref="InterPro:IPR020203" /db_xref="SubtiList:BG11252" /db_xref="UniProtKB/Swiss-Prot:P45711" /translation="MLEGWFLWFILFWVIMMVVLLSIGGFFMFRKFLKRLPKEDGRSE LDWQDYYIENSRHLWNDENKQFLDELTAPVPELFRDAAKAKIAGKIGELALKEKVAKI DQQLMIKGYILATPKRDHTFLKRHLRDKKIDLEPYQTLLK*" /label="yneK CDS" gene complement(1713966..1714394) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /label="yneK gene" downshifts complement(1713983) /Source="Nicolas_upshifts" /id="D979" /incds=0 /nref=188 /ntot=245 /MaxReadThrough="1.60911" /MaxDrop="5.09033" /score="10.710816" /energy="-9.7" /TU="NA" /idTUdmin="U1449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1714412..1714431) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1714424) /Source="Nicolas_upshifts" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1714426..1714511) /Source="Nicolas_S_feature" /locus_tag="new_1925453_1925538_c" /HighExp="S8, S6, S7, LBGstat, C30, dia15, S0, Cold, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.958, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S664" promotor_-35 complement(1714445..1714452) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1714482..1714491 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1714501..1714610 /Source="Nicolas_S_feature" /locus_tag="new_1925528_1925637" /HighExp="S8, BT, B36, S7, G/S, Pyr, B60, S6, Glucon, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S665" upshifts 1714501 /Source="Nicolas_upshifts" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1714504..1714523 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1714506..1714525) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1714511) /Source="Nicolas_upshifts" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1714513..1714596) /Source="Nicolas_S_feature" /locus_tag="new_1925540_1925623_c" /HighExp="S8, S6, S7, C30, BT, S5, Pyr, Glucon, BC, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S666" promotor_-35 complement(1714540..1714543) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1714567 /Source="Nicolas_upshifts" /id="D980" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="3.76639" /MaxDrop="5.34013" /score="5.70696998" /energy="-12.7" /TU="U1450" /idTUdmin="U1450" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1714628..1715020) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9068633, 11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068633, 11150673; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389680.1" /db_xref="EnsemblGenomes-Gn:BSU17970" /db_xref="EnsemblGenomes-Tr:CAB13681" /db_xref="GOA:Q45058" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11822" /db_xref="UniProtKB/Swiss-Prot:Q45058" /translation="MWRNASMNHSKRNDANDFDSMDEWLRQFFEDPFAWYDETLPIDL YETSQQYIIEADLTFLQPTQVTVTLSGCEFILTVKSSGQTFEKQMMLPFYFNDKNIQV ECENQILTVAVNKETEDGSSFSLQFPLS*" /label="cotM CDS" gene complement(1714628..1715020) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /label="cotM gene" downshifts complement(1714641) /Source="Nicolas_upshifts" /id="D981" /incds=0 /nref=20 /ntot=92 /MaxReadThrough="4.44864" /MaxDrop="4.9615" /score="11.5991121" /energy="-12.7" /TU="U1454" /idTUdmin="U1456" /TUdmin=486 /isTUend="FALSE" /label="downshifts" promotor_-35 1714863..1714868 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-35" promotor_-10 1714884..1714902 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-10" upshifts 1714888 /Source="Nicolas_upshifts" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="upshifts" promotor_-35 1714998..1715002 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1715012..1715026 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1715027..1715046) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1715029 /Source="Nicolas_upshifts" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1715042) /Source="Nicolas_upshifts" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1715060..1715069) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1715101..1715247) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389681.1" /db_xref="EnsemblGenomes-Gn:BSU17980" /db_xref="EnsemblGenomes-Tr:CAB13682" /db_xref="GOA:P71032" /db_xref="InterPro:IPR012614" /db_xref="SubtiList:BG11921" /db_xref="UniProtKB/Swiss-Prot:P71032" /translation="MTNKNTSKDMHKNAPKGHNPGQPEPLSGSKKVKNRNHTRQKHNS SHDM*" /label="sspP CDS" gene complement(1715101..1715247) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /label="sspP gene" downshifts complement(1715122) /Source="Nicolas_upshifts" /id="D982" /incds=0 /nref=42 /ntot=61 /MaxReadThrough="1.80349" /MaxDrop="6.88836" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1456" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1715279..1715425) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018, 10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018, 10806362; Product type s: structure" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389682.1" /db_xref="EnsemblGenomes-Gn:BSU17990" /db_xref="EnsemblGenomes-Tr:CAB13683" /db_xref="GOA:P71031" /db_xref="InterPro:IPR012613" /db_xref="SubtiList:BG11920" /db_xref="UniProtKB/Swiss-Prot:P71031" /translation="MVKRKANHVINGMNDAKSQGKGAGYIENDQLVLTEAERQNNKKR KTNQ*" /label="sspO CDS" gene complement(1715279..1715425) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /label="sspO gene" S_feature 1715425..1715558 /Source="Nicolas_S_feature" /locus_tag="new_1926452_1926585" /HighExp="S8, S7, S3, S6, LoTm, S4, S5, BT, Pyr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S667" upshifts 1715425 /Source="Nicolas_upshifts" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1715436..1715438 /Source="Nicolas_upshift_promotors" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(1715441..1715452) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1715455) /Source="Nicolas_upshifts" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1715467..1715473) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1715548..1715555 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1715560..1715652 /Source="Nicolas_S_feature" /locus_tag="new_1926587_1926679" /HighExp="B60, M40t90, T0.0H, HiOs, T4.0H, T5.0H, T2.30H, M0t90, Sw, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S668" upshifts 1715560 /Source="Nicolas_upshifts" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1715570..1715589 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1715611) /Source="Nicolas_upshifts" /id="D983" /incds=0 /nref=1 /ntot=67 /MaxReadThrough="2.77282" /MaxDrop="4.02811" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1458" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1715653..1718382 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /EC_number="4.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate hydratase (bifunctional aconitase)" /protein_id="NP_389683.1" /db_xref="EnsemblGenomes-Gn:BSU18000" /db_xref="EnsemblGenomes-Tr:CAB13684" /db_xref="GOA:P09339" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR006249" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG10478" /db_xref="UniProtKB/Swiss-Prot:P09339" /translation="MANEQKTAAKDVFQARKTFTTNGKTYHYYSLKALEDSGIGKVSK LPYSIKVLLESVLRQVDGFVIKKEHVENLAKWGTAELKDIDVPFKPSRVILQDFTGVP AVVDLASLRKAMAAVGGDPDKINPEIPVDLVIDHSVQVDKAGTEDALAVNMDLEFERN AERYKFLSWAKKAFNNYQAVPPATGIVHQVNLEFLASVVHAIEEDGELVTYPDTLVGT DSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPVPEVIGAKLVGKLPNGTTATDLAL KVTQVLREKGVVGKFVEFFGPGIAELPLADRATIANMAPEYGATCGFFPVDEEALNYL RLTGRDPEHIDVVEAYCRSNGLFYTPDAEDPQFTDVVEIDLSQIEANLSGPKRPQDLI PLSAMQETFKKQLVSPAGNQGFGLNAEEENKEIKFKLLNGEETVMKTGAIAIAAITSC TNTSNPYVLIGAGLVAKKAVELGLKVPNYVKTSLAPGSKVVTGYLVNSGLLPYMKELG FNLVGYGCTTCIGNSGPLSPEIEEAVAKNDLLITSVLSGNRNFEGRIHPLVKGNYLAS PPLVVAYALAGTVNINLKTDPIGVGKDGQNVYFNDIWPSMDEINALVKQTVTPELFRK EYETVFDDNKRWNEIETTDEALYKWDNDSTYIQNPPFFEEMSVEPGKVEPLKGLRVVG KFGDSVTTDHISPAGAIGKDTPAGKYLQEKGVSPRDFNSYGSRRGNHEVMMRGTFANI RIKNQIAPGTEGGFTTYWPTGEVTSIYDACMKYKEDKTGLVVLAGKDYGMGSSRDWAA KGTNLLGIRTVIAESFERIHRSNLVFMGVLPLQFKQGENADTLGLTGKEVIEVDVDET VRPRDLVTVRAINEDGNVTTFEAVVRFDSEVEIDYYRHGGILQMVLREKMKQS*" /label="citB CDS" gene 1715653..1718382 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /label="citB gene" misc_feature complement(1715673..1715677) /Source="Nicolas_upshift_promotors" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1715677) /Source="Nicolas_upshifts" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1718383..1718453 /Source="Nicolas_S_feature" /locus_tag="new_1929410_1929480" /HighExp="M9-stat, B60, M40t90, Glucon, M0t90, MG-0.2, Mal, T2.30H, MG-0.1, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S669" CDS 1718454..1718966 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15342593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane-bound proteins with a thioredoxin-like domain" /protein_id="NP_389684.1" /db_xref="EnsemblGenomes-Gn:BSU18010" /db_xref="EnsemblGenomes-Tr:CAB13685" /db_xref="GOA:O31820" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13451" /db_xref="UniProtKB/Swiss-Prot:O31820" /translation="MLKKWLAGILLIMLVGYTGWNLYQTYSKKEVGIQEGQQAPDFSL KTLSGEKSSLQDAKGKKVLLNFWATWCKPCRQEMPAMEKLQKEYADKLAVVAVNFTSA EKSEKQVRAFADTYDLTFPILIDKKGINADYNVMSYPTTYILDEKGVIQDIHVGTMTK KEMEQKLDLD*" /label="yneN CDS" gene 1718454..1718966 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /label="yneN gene" downshifts 1718923 /Source="Nicolas_upshifts" /id="D984" /incds=0 /nref=115 /ntot=218 /MaxReadThrough="3.76369" /MaxDrop="5.09954" /score="13.5401842" /energy="-6.9" /TU="U1457" /idTUdmin="U1457" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-35 1718992..1718998 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1719011 /Source="Nicolas_upshifts" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1719013..1719024 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1719047..1719172 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097732.1" /db_xref="EnsemblGenomes-Gn:BSU18019" /db_xref="EnsemblGenomes-Tr:CAX52626" /db_xref="InterPro:IPR025004" /db_xref="UniProtKB/Swiss-Prot:C0H418" /translation="MKKMRKRSFHELVMENKKELMTNTEYLNQLEEKLEQRFKQK*" /label="ynzL CDS" gene 1719047..1719172 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /label="ynzL gene" downshifts complement(1719065) /Source="Nicolas_upshifts" /id="D985" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.12259" /MaxDrop="3.48183" /score="-0.0160782027" /energy="-13.9" /TU="NA" /idTUdmin="U1462" /TUdmin=1298 /isTUend="FALSE" /label="downshifts" promotor_-35 1719186..1719192 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1719207..1719218 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1719209 /Source="Nicolas_upshifts" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" CDS 1719237..1719383 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054579.2" /db_xref="EnsemblGenomes-Gn:BSU18020" /db_xref="EnsemblGenomes-Tr:CAE01455" /db_xref="GOA:Q7WY69" /db_xref="InterPro:IPR012612" /db_xref="SubtiList:BG14179" /db_xref="UniProtKB/Swiss-Prot:Q7WY69" /translation="MGNNKKNGQPQYAPSHLGTKPVKYKANKGEKMHDTSGQRPIIMQ TKGE*" /label="sspN CDS" gene 1719237..1719383 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /label="sspN gene" CDS 1719420..1719671 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (thioredoxin-like protein)" /protein_id="NP_389685.1" /db_xref="EnsemblGenomes-Gn:BSU18030" /db_xref="EnsemblGenomes-Tr:CAB13686" /db_xref="GOA:Q45060" /db_xref="InterPro:IPR017524" /db_xref="SubtiList:BG11806" /db_xref="UniProtKB/Swiss-Prot:Q45060" /translation="MTKNQNQYQQPNPDDRSDNVEKLQDMVQNTIENIEEAEASMEFA SGEDKQRIKEKNARREQSIEAFRNEIQDESAARQNGYRS*" /label="sspT CDS" gene 1719420..1719671 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /label="sspT gene" downshifts 1719649 /Source="Nicolas_upshifts" /id="D986" /incds=0 /nref=41 /ntot=49 /MaxReadThrough="2.07653" /MaxDrop="7.06685" /score="32.1193211" /energy="-7" /TU="NA" /idTUdmin="U1457" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1719692..1719697 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1719711..1719730 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1719715..1719806 /Source="Nicolas_S_feature" /locus_tag="new_1930742_1930833" /HighExp="Etha, dia5, dia15, Diami, H2O2, G180, Salt, G150, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S670" upshifts 1719715 /Source="Nicolas_upshifts" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1719807..1720172 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /EC_number="3.1.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11959124, 11994151, 16294310, 18338382; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA thioesterase" /protein_id="YP_054580.1" /db_xref="EnsemblGenomes-Gn:BSU18040" /db_xref="EnsemblGenomes-Tr:CAB13687" /db_xref="GOA:Q45061" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR006684" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11823" /db_xref="UniProtKB/Swiss-Prot:Q45061" /translation="MGIVYHANYLVWMEVGRTALIKDLGFLYSDMEKKGVLSPVVDIN ISYKKPLHYGETAVVHTWIEDYNGFKTVYGYHIYNPAGELSIKATSSHICVDKESFKP IQFRKAFPDWHTAYEKAKK*" /label="yneP CDS" gene 1719807..1720172 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /label="yneP gene" CDS 1720188..1720487 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389687.1" /db_xref="EnsemblGenomes-Gn:BSU18050" /db_xref="EnsemblGenomes-Tr:CAB13688" /db_xref="SubtiList:BG11824" /db_xref="UniProtKB/Swiss-Prot:Q45062" /translation="MAFGVKREELNRWKQAVKRGEIAFLTHYWLDDRFPEAKTVTKAG CADIDKLVQWGAAYGLKKEWIHKKSEFPHFDLLGETQKYILEQENLTDHLIRFHL*" /label="yneQ CDS" gene 1720188..1720487 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /label="yneQ gene" downshifts 1720463 /Source="Nicolas_upshifts" /id="D987" /incds=0 /nref=55 /ntot=217 /MaxReadThrough="3.04989" /MaxDrop="5.5978" /score="-4.41102273" /energy="-6" /TU="NA" /idTUdmin="U1461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1720518..1720805) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 23176286" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389688.1" /db_xref="EnsemblGenomes-Gn:BSU18060" /db_xref="EnsemblGenomes-Tr:CAB13689" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR008326" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11825" /db_xref="UniProtKB/Swiss-Prot:Q45063" /translation="MNMTINEDALNWYKEELDLESGDQVRFFVRYGGCSNVQKGFSLG VAKDAPQEAGVTAEADGITFFIEESDLWYFDNHDLLVSYSEDADEPVFEYQ*" /label="yneR CDS" gene complement(1720518..1720805) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /label="yneR gene" downshifts complement(1720539) /Source="Nicolas_upshifts" /id="D988" /incds=0 /nref=216 /ntot=260 /MaxReadThrough="3.77766" /MaxDrop="7.20006" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(1720605) /Source="Nicolas_upshifts" /id="D989" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.5674" /MaxDrop="3.11178" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1720835..1720854) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1720847) /Source="Nicolas_upshifts" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1720870..1720877) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1720893..1721474) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphate:glycerol-3-phosphate O-acyltransferase" /protein_id="NP_389689.1" /db_xref="EnsemblGenomes-Gn:BSU18070" /db_xref="EnsemblGenomes-Tr:CAB13690" /db_xref="GOA:Q45064" /db_xref="InterPro:IPR003811" /db_xref="SubtiList:BG11826" /db_xref="UniProtKB/Swiss-Prot:Q45064" /translation="MLIALLIILAYLIGSIPSGLIVGKLAKGIDIREHGSGNLGATNA FRTLGVKAGSVVIAGDILKGTLATALPFLMHVDIHPLLAGVFAVLGHVFPIFAKFKGG KAVATSGGVLLFYAPLLFITMVAVFFIFLYLTKFVSLSSMLTGIYTVIYSFFVHDTYL LIVVTLLTIFVIYRHRANIKRIINKTEPKVKWL*" /label="plsY CDS" gene complement(1720893..1721474) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /label="plsY gene" S_feature 1721475..1721605 /Source="Nicolas_S_feature" /locus_tag="new_1932502_1932632" /HighExp="C30, S8, S7, S5, S6, S4, BC, S3, T4.0H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S671" misc_feature complement(1721500..1721519) /Source="Nicolas_upshift_promotors" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1721517) /Source="Nicolas_upshifts" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1721590..1721593 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1721607 /Source="Nicolas_upshifts" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1721609..1721628 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1721644..1722051 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA-binding protein" /protein_id="NP_389690.1" /db_xref="EnsemblGenomes-Gn:BSU18080" /db_xref="EnsemblGenomes-Tr:CAB13691" /db_xref="GOA:Q45065" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11827" /db_xref="UniProtKB/Swiss-Prot:Q45065" /translation="MQNPSKAEIKEILQRSKRIAVVGLSDRPDRTSHMVSKAMQDAGY EIIPVNPTIDEALGVKAVSSLKEIDGPIDIVNVFRRSEQLPGVAEEFLETDAPVFWAQ QGLVNEEAYQMLKEKGRTVIMDLCIKVAHAVTK*" /label="yneT CDS" gene 1721644..1722051 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /label="yneT gene" downshifts 1722047 /Source="Nicolas_upshifts" /id="D990" /incds=0 /nref=63 /ntot=221 /MaxReadThrough="4.35976" /MaxDrop="5.49229" /score="-2.11194139" /energy="-6" /TU="U1464" /idTUdmin="U1461" /TUdmin=1584 /isTUend="FALSE" /label="downshifts" promotor_-35 1722113..1722116 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1722131..1722150 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1722135..1722449 /Source="Nicolas_S_feature" /locus_tag="new_1933162_1933476" /HighExp="H2O2, G150, G180, Etha, Oxctl, LBGexp, dia0, Lbexp, M40t45, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S672" upshifts 1722135 /Source="Nicolas_upshifts" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" CDS 1722450..1724417 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8969507, 9539793, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8969507, 9539793, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit B of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389691.2" /db_xref="EnsemblGenomes-Gn:BSU18090" /db_xref="EnsemblGenomes-Tr:CAB13692" /db_xref="GOA:Q59192" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005740" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11804" /db_xref="UniProtKB/Swiss-Prot:Q59192" /translation="MARKQQFDYNEDAIQVLEGLEAVRKRPGMYIGSTDARGLHHLVY EIVDNSVDEVLAGHGDHIIVKIHKDNSISVQDRGRGMPTGMHKLGKPTPEVILTVLHA GGKFGQGGYKTSGGLHGVGASVVNALSEWLTVTIERDGFVYQQRFENGGKPVTSLEKI GKTKKTGTLTHFKPDPTMFSTTTYNFETLSERLRESAFLLKGLKIELIDERNDQREVF YYENGIEAFVAYLNEEKDVLSEVVSFEGEHHSIEVDFAFQFNDGYSENILSFVNNVRT KDGGTHESGAKTAMTRAFNEYARKVALLKEKDKNLEGTDIREGLSAIISVRIPEELLQ FEGQTKGKLGTSEARSAVDAIVSEQLAYFLEENRDTATLLVKKAIKASQAREAARKAR EEARSGKKRKKSEATLSGKLTPAGSRNPAKNELYLVEGDSAGGSAKQGRDRRFQAVLP LRGKVINTEKAKLADIFKNEEINTIIHAIGGGVGADFSIDDINYDKIIIMTDADTDGA HIQVLLLTFFYRYMKPLIEHGKVFIALPPLYKVSKGSGKKEIIEYAWSDEEMGDVLKK VGKGYTIQRYKGLGEMNADQLWETTMNPESRTLVRVKIDDAARVERRVTTLMGDKVEP RRKWIEKNVAFGLDEESNILENENLSVAEEV*" /label="parE CDS" gene 1722450..1724417 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /label="parE gene" CDS 1724421..1726841 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9539793, 12682299, 16267290, 16272394, 24440393" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9539793, 12682299, 16267290, 16272394, 24440393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit A of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389692.2" /db_xref="EnsemblGenomes-Gn:BSU18100" /db_xref="EnsemblGenomes-Tr:CAB13693" /db_xref="GOA:Q45066" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005741" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="SubtiList:BG11803" /db_xref="UniProtKB/Swiss-Prot:Q45066" /translation="MSQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQ RRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLI EMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPA MFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPT GGIIQGVDGIRKAYETGKGKIIIRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMD EFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYKNTDLQITYNFNMVA IHNRRPMLMSLPSILDAYIGHQKEVVTNRSVYELQKAKDRHHIVEGLMKALSILDEVI ATIRSSSDKRDAKNNLIAKYEFTEPQAEAIVSLQLYRLTNTDITALKEEAEELGKKIE ELESILSNDKKLLKVITNSLKALKKKYADTRRSVIEEKIEEIKINLEVMVASEDVYVT VTKDGYLKRTSQRSFAASNGQDFGMKDTDRMLHQFEMNTTDVLLLFTNKGSYIYCPVH QLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKEFDPSAYLLFFTKNGMVKKTELTHY KAQRYSKALVALNLKGEDELIDVHVTNGESQIFMATHLGYGLWFGEDEVNVVGARAAG VKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSLSEFEKTSRAKRGVVMLRELK KNPHRVVALFACGLEQRLMAETEKGDRKELQTKELRTNDRYSNGSFFFDEEESGKVTA VWRLHTEQ*" /label="parC CDS" gene 1724421..1726841 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /label="parC gene" downshifts 1726821 /Source="Nicolas_upshifts" /id="D991" /incds=0 /nref=227 /ntot=255 /MaxReadThrough="0.556700000000001" /MaxDrop="5.87714" /score="9.15080033" /energy="-14.6" /TU="NA" /idTUdmin="U1465" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1726849..1727038) /Source="Nicolas_S_feature" /locus_tag="new_1937876_1938065_c" /HighExp="LPhT, B60, Etha, B36, Gly, LoTm, Sw, BC, S8, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99806099999999998" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="0.968, 0.994, 0.642" /TUlongSig="NA" /TUlongPSig="NA" /label="S673" CDS complement(1726888..1727064) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (C-terminus)" /db_xref="PSEUDO:SOX90559.1" /translation="MFNITRLCNENMRRLLNMLFILRMVILGLFSFTALNLFVWQGIE VIHAVTDLFTNHES*" /label="ynfCc CDS" gene complement(1726888..1727064) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /pseudo /label="ynfCc gene" downshifts complement(1726892) /Source="Nicolas_upshifts" /id="D992" /incds=0 /nref=153 /ntot=267 /MaxReadThrough="0.609599999999999" /MaxDrop="7.72532" /score="38.0779167" /energy="-14.6" /TU="NA" /idTUdmin="U1467" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1727039..1727449) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU18110" /db_xref="EnsemblGenomes-Tr:CAB13694" /db_xref="GOA:Q45067" /db_xref="PSEUDO:CAB13694.1" /db_xref="SubtiList:BG11828" /db_xref="UniProtKB/Swiss-Prot:Q45067" /translation="MDWGIIIKIFSNIKGGGDHLKKVTILKASILFLAIASFHLFSIP HAFDIGHHYKAVADQQEMHEMKAGQNADDEKKSITGAFTLTALWAMAVLLLTAESKST GYSRRRQRKKSFILAKFYQSSYFGKLHVQHHPIM*" /label="ynfCn CDS" gene complement(1727039..1727449) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /pseudo /label="ynfCn gene" promotor_-10 complement(1727422..1727441) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1727425) /Source="Nicolas_upshifts" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1727456..1727463) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1727490..1727509) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1727491) /Source="Nicolas_upshifts" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1727524..1727531) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1727538..1727557) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1727549) /Source="Nicolas_upshifts" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1727571..1727580) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1727797..1727802 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1727815..1727834 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1727820 /Source="Nicolas_upshifts" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="upshifts" S_feature 1727833..1727897 /Source="Nicolas_S_feature" /locus_tag="new_1938860_1938924" /HighExp="Cold, G180, Oxctl, G135, LBGexp, G150, HPh, dia0, Lbexp, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S674" CDS 1727898..1729295 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8969507, 12823818, 15849754, 16850406, 22607086; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+/Na+:nitrogen-donor aminoacid symporter" /protein_id="NP_389694.1" /db_xref="EnsemblGenomes-Gn:BSU18120" /db_xref="EnsemblGenomes-Tr:CAB13695" /db_xref="GOA:Q45068" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG11798" /db_xref="UniProtKB/Swiss-Prot:Q45068" /translation="MESFFNSLINIPSDFIWKYLFYILIGLGLFFTIRFGFIQFRYFI EMFRIVGEKPEGNKGVSSMQAFFISAASRVGTGNLTGVALAIATGGPGAVFWMWVVAA VGMASSFVESTLAQLYKVRDGEDFRGGPAYYIQKGLGARWLGIVFAILITVSFGLIFN AVQTNTIAGALDGAFHVNKIVVAIVLAVLTAFIIFGGLKRVVAVSQLIVPVMAGIYIL IALFVVITNITAFPGVIATIVKNALGFEQVVGGGIGGIIVIGAQRGLFSNEAGMGSAP NAAATAHVSHPAKQGFIQTLGVFFDTFIICTSTAFIILLYSVTPKGDGIQVTQAALNH HIGGWAPTFIAVAMFLFAFSSVVGNYYYGETNIEFIKTSKTWLNIYRIAVIAMVVYGS LSGFQIVWDMADLFMGIMALINLIVIALLSNVAYKVYKDYAKQRKQGLDPVFKAKNIP GLKNAETWEDEKQEA*" /label="alsT CDS" gene 1727898..1729295 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /label="alsT gene" downshifts 1729284 /Source="Nicolas_upshifts" /id="D993" /incds=0 /nref=112 /ntot=203 /MaxReadThrough="3.44078" /MaxDrop="5.75319" /score="16.664707" /energy="-14.7" /TU="U1469" /idTUdmin="U1469" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 1729329 /Source="Nicolas_upshifts" /id="D994" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.22962" /MaxDrop="5.03444" /score="16.664707" /energy="-14.7" /TU="NA" /idTUdmin="U1469" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(1729385..1730131) /Source="Nicolas_S_feature" /locus_tag="new_1940412_1941158_c" /HighExp="S6, S8, S7, S5, BT, C30, B36, S4, LoTm, B60" /AntisenseName="eglS" /AntisenseCor="0.42607634596628102" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S675" promotor_-35 1729508..1729515 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1729527 /Source="Nicolas_upshifts" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1729528..1729547 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1729598..1731097 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /EC_number="3.2.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3024130, 7704256, 7710279, 15139916, 26907762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3024130, 7704256, 7710279, 15139916, 26907762; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-1,4-beta-glucanase" /protein_id="NP_389695.2" /db_xref="EnsemblGenomes-Gn:BSU18130" /db_xref="EnsemblGenomes-Tr:CAB13696" /db_xref="GOA:P10475" /db_xref="InterPro:IPR001547" /db_xref="InterPro:IPR001956" /db_xref="InterPro:IPR008965" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018087" /db_xref="InterPro:IPR036966" /db_xref="PDB:2L8A" /db_xref="PDB:3PZT" /db_xref="PDB:3PZU" /db_xref="PDB:3PZV" /db_xref="SubtiList:BG10437" /db_xref="UniProtKB/Swiss-Prot:P10475" /translation="MKRSISIFITCLLITLLTMGGMIASPASAAGTKTPVAKNGQLSI KGTQLVNRDGKAVQLKGISSHGLQWYGEYVNKDSLKWLRDDWGITVFRAAMYTADGGY IDNPSVKNKVKEAVEAAKELGIYVIIDWHILNDGNPNQNKEKAKEFFKEMSSLYGNTP NVIYEIANEPNGDVNWKRDIKPYAEEVISVIRKNDPDNIIIVGTGTWSQDVNDAADDQ LKDANVMYALHFYAGTHGQFLRDKANYALSKGAPIFVTEWGTSDASGNGGVFLDQSRE WLKYLDSKTISWVNWNLSDKQESSSALKPGASKTGGWRLSDLSASGTFVRENILGTKD STKDIPETPSKDKPTQENGISVQYRAGDGSMNSNQIRPQLQIKNNGNTTVDLKDVTAR YWYKAKNKGQNFDCDYAQIGCGNVTHKFVTLHKPKQGADTYLELGFKNGTLAPGASTG NIQLRLHNDDWSNYAQSGDYSFFKSNTFKTTKKITLYDQGKLIWGTEPN*" /label="eglS CDS" gene 1729598..1731097 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /label="eglS gene" promotor_-10 complement(1730130..1730149) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1730153) /Source="Nicolas_upshifts" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1730163..1730172) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1731045 /Source="Nicolas_upshifts" /id="D995" /incds=0 /nref=1 /ntot=89 /MaxReadThrough="3.59763" /MaxDrop="3.67571" /score="6.04626297" /energy="-10.7" /TU="NA" /idTUdmin="U1470" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1731165..1731428 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389696.1" /db_xref="EnsemblGenomes-Gn:BSU18140" /db_xref="EnsemblGenomes-Tr:CAB13697" /db_xref="InterPro:IPR020302" /db_xref="SubtiList:BG11829" /db_xref="UniProtKB/Swiss-Prot:Q45069" /translation="MDEILKQYMVLYKKMSNMINGPDYPGKEKDIQHQKDQIEVYEKQ LQQGFSTDYDYDVFADSVIKCAYGDMTLEDLEAVYYGLTTPFF*" /label="ynfE CDS" gene 1731165..1731428 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /label="ynfE gene" downshifts complement(1731687) /Source="Nicolas_upshifts" /id="D996" /incds=0 /nref=4 /ntot=148 /MaxReadThrough="1.78569" /MaxDrop="4.04338" /score="32.2414244" /energy="-12.6" /TU="NA" /idTUdmin="U1472" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1731687..1732955) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /EC_number="3.2.1.136" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17028274, 25355936, 26559526, 28330222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17028274, 25355936, 26559526, 28330222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-xylanase" /protein_id="NP_389697.1" /db_xref="EnsemblGenomes-Gn:BSU18150" /db_xref="EnsemblGenomes-Tr:CAB13698" /db_xref="GOA:Q45070" /db_xref="InterPro:IPR001139" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR033452" /db_xref="PDB:3GTN" /db_xref="PDB:3KL0" /db_xref="PDB:3KL3" /db_xref="PDB:3KL5" /db_xref="SubtiList:BG11830" /db_xref="UniProtKB/Swiss-Prot:Q45070" /translation="MIPRIKKTICVLLVCFTMLSVMLGPGATEVLAASDVTVNVSAEK QVIRGFGGMNHPAWAGDLTAAQRETAFGNGQNQLGFSILRIHVDENRNNWYKEVETAK SAVKHGAIVFASPWNPPSDMVETFNRNGDTSAKRLKYNKYAAYAQHLNDFVTFMKNNG VNLYAISVQNEPDYAHEWTWWTPQEILRFMRENAGSINARVIAPESFQYLKNLSDPIL NDPQALANMDILGTHLYGTQVSQFPYPLFKQKGAGKDLWMTEVYYPNSDTNSADRWPE ALDVSQHIHNAMVEGDFQAYVWWYIRRSYGPMKEDGTISKRGYNMAHFSKFVRPGYVR IDATKNPNANVYVSAYKGDNKVVIVAINKSNTGVNQNFVLQNGSASNVSRWITSSSSN LQPGTNLTVSGNHFWAHLPAQSVTTFVVNR*" /label="xynC CDS" gene complement(1731687..1732955) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /label="xynC gene" S_feature complement(1732956..1733085) /Source="Nicolas_S_feature" /locus_tag="new_1943983_1944112_c" /HighExp="Lbstat, BC, M0t90, LBGstat, Sw, T2.0H, M40t90, BI, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99419599999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S676" CDS complement(1733086..1734627) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1938968, 17426966, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938968, 17426966, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinoxylan arabinofuranohydrolase" /protein_id="NP_389698.1" /db_xref="EnsemblGenomes-Gn:BSU18160" /db_xref="EnsemblGenomes-Tr:CAB13699" /db_xref="GOA:Q45071" /db_xref="InterPro:IPR005084" /db_xref="InterPro:IPR006584" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR023296" /db_xref="PDB:3C7E" /db_xref="PDB:3C7F" /db_xref="PDB:3C7G" /db_xref="PDB:3C7H" /db_xref="PDB:3C7O" /db_xref="SubtiList:BG11807" /db_xref="UniProtKB/Swiss-Prot:Q45071" /translation="MRKKCSVCLWILVLLLSCLSGKSAYAATSTTIAKHIGNSNPLID HHLGADPVALTYNGRVYIYMSSDDYEYNSNGTIKDNSFANLNRVFVISSADMVNWTDH GAIPVAGANGANGGRGIAKWAGASWAPSIAVKKINGKDKFFLYFANSGGGIGVLTADS PIGPWTDPIGKPLVTPSTPGMSGVVWLFDPAVFVDDDGTGYLYAGGGVPGVSNPTQGQ WANPKTARVIKLGPDMTSVVGSASTIDAPFMFEDSGLHKYNGTYYYSYCINFGGTHPA DKPPGEIGYMTSSSPMGPFTYRGHFLKNPGAFFGGGGNNHHAVFNFKNEWYVVYHAQT VSSALFGAGKGYRSPHINKLVHNADGSIQEVAANYAGVTQISNLNPYNRVEAETFAWN GRILTEKSTAPGGPVNNQHVTSIQNGDWIAVGNADFGAGGARSFKANVASTLGGKIEV RLDSADGKLVGTLNVPSTGGAQTWREIETAVSGATGVHKVFFVFTGTGTGNLFNFDYW QFTQR*" /label="xynD CDS" gene complement(1733086..1734627) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /label="xynD gene" S_feature complement(1734628..1734949) /Source="Nicolas_S_feature" /locus_tag="new_1945655_1945976_c" /HighExp="M0t90, LBGstat, T1.30H, T2.30H, BC, M9-stat, T2.0H, T3.0H, T0.30H, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25588499999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S677" promotor_-10 complement(1734939..1734958) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1734950) /Source="Nicolas_upshifts" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1734973..1734976) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1735176..1735183 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1735196..1735215 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1735203 /Source="Nicolas_upshifts" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1735222..1735668 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein possibly involved in arabinogalactan metabolism" /protein_id="NP_389699.1" /db_xref="EnsemblGenomes-Gn:BSU18170" /db_xref="EnsemblGenomes-Tr:CAB13700" /db_xref="GOA:O31821" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG13452" /db_xref="UniProtKB/Swiss-Prot:O31821" /translation="MTATRIFYEGRFVTLKEKIKTLGRFCTVGVGNTLIDFGVFFLLT ACHVSYLPAQICSYTAGIVNSYVWNRNWTFCVKRKADGKEIVRFLMINIAASGITFLL LYLFQNCGCSLLVSKLAATIGGMMMNFIGNRIWVFGDSLKNIQDQE*" /label="yngA CDS" gene 1735222..1735668 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /label="yngA gene" CDS 1735675..1736568 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /EC_number="2.7.7.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8320212, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_389700.1" /db_xref="EnsemblGenomes-Gn:BSU18180" /db_xref="EnsemblGenomes-Tr:CAB13701" /db_xref="GOA:O31822" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13453" /db_xref="UniProtKB/Swiss-Prot:O31822" /translation="MRKKVRKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPAIQYIVE EAAESGIEDILIITGRNKRSIEDHFDRSAELEFNLREKGKTETLKEMQQIADLANIHY IRQKEPLGLGHAVLCAEHFIGDEPFAVLLGDDIMVSETPALRQLMDVYDVYGTEVVGV QSVLPEDVSKYGIINTSGSQGHVYEVNDLVEKPSPEEAPSEIAVMGRYVLNSSIFSVL KTIGRGAGNEIQLTDALREVCRKEPIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEM RSQLLAYLEDVIKRETKEMLR*" /label="yngB CDS" gene 1735675..1736568 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /label="yngB gene" misc_feature 1736185..1736204 /Source="Nicolas_upshift_promotors" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1736193 /Source="Nicolas_upshifts" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="upshifts" CDS 1736641..1737237 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein, phosphatase or phosphate isomerase" /protein_id="NP_389701.1" /db_xref="EnsemblGenomes-Gn:BSU18190" /db_xref="EnsemblGenomes-Tr:CAB13702" /db_xref="GOA:O31823" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13454" /db_xref="UniProtKB/Swiss-Prot:O31823" /translation="MGSLISEILTWLTNMGYAGIAIGLMIEIIPSEIVLAYGGYMVSE GTIGFIGAIIAGVIGGTIAQIFIYWIGRYGGRPFLDKYGKYLLIKKHHIDMSENWFQK YGAGVVFSARFIPVVRHAISIPAGIARMPFLKFVVLTVLAIIPWSILFVYLGIQLGSQ WDDVENIAGTYTTPIMILAVVVIALYFVIKKRTAIFKR*" /label="yngC CDS" gene 1736641..1737237 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /label="yngC gene" downshifts 1737227 /Source="Nicolas_upshifts" /id="D997" /incds=0 /nref=191 /ntot=259 /MaxReadThrough="1.94273" /MaxDrop="5.58345" /score="15.4353025" /energy="-15" /TU="NA" /idTUdmin="U1474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1737286..1738485) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19553197, 22262096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19553197, 22262096; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoribonuclease (nanoRNase)" /protein_id="NP_389702.1" /db_xref="EnsemblGenomes-Gn:BSU18200" /db_xref="EnsemblGenomes-Tr:CAB13703" /db_xref="GOA:O31824" /db_xref="SubtiList:BG13455" /db_xref="UniProtKB/Swiss-Prot:O31824" /translation="MYHLYSHNDLDGVGCGIVAKLAFGKDVEIRYNSVNGLNAQVQYF LEKAKESNRQDALFITDLAVNEENEERLNEYVHAGGKVKLIDHHKTALHLNEHEWGFV QVEYDDGRLTSATSLLYGYLIENGFMKPTNALDQFTELVRQYDTWEWERYDQKQAKRL NDLFFLLSIDEFEAKMIQRLSTHDEFFFDDFEEKLLDLEDEKIERYLRRKKREMVQTF VHEHCVGIVHAESYHSELGNRLGKDNPHLDYIAILSMGSKRVSLRTIHDYIDVSEIAG RYGGGGHAKASGCSITDEVYELFVAEAFRIDPVRPDAFRNIYNLKGSANGSLYENRAQ MRFFLFPLDNEWNIQINGETQDETFAAFEEAEWFIKRNYAASLVRDEVFVAFLAENLK LANQHRK*" /label="nrnB CDS" gene complement(1737286..1738485) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /label="nrnB gene" S_feature complement(1738486..1738557) /Source="Nicolas_S_feature" /locus_tag="new_1949513_1949584_c" /HighExp="S5, S7, S4, S8, S6, ferm, nit, LBGstat, T5.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S678" promotor_-10 complement(1738545..1738556) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1738557) /Source="Nicolas_upshifts" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1738571..1738577) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1738655..1740190) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /EC_number="6.4.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylcrotonoyl-CoA carboxylase subunit (leucinedegradation)" /protein_id="NP_389703.2" /db_xref="EnsemblGenomes-Gn:BSU18210" /db_xref="EnsemblGenomes-Tr:CAB13704" /db_xref="GOA:O31825" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13456" /db_xref="UniProtKB/Swiss-Prot:O31825" /translation="MLMDYEKERTERAERIRKGGAEKYHQSNREKGKLFVRERLSLLF DDDIELEDAFFAECMSDGLPADGVVTAIGKIGGQTVCVMANDSTVKAGSWGAKTVEKI IRIQEIAEKLNCPLIYLVDSAGARITDQINVFPGRRGAGRIFYNQVKLSGRIPQICLL FGPSAAGGAYIPAFCDIVVMVDGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSIS GCGDILAETEEEAIQLVRAYLSYFPANFQEKAPIHEKRPPKHFETPLADVIPQNQNAP FDMHELIERVIDEDSFFEIKALFAPELLTGLARIHGQPVGIVANQPKVKGGVLFHDSA DKAAKFITLCDAFHIPLLFLADIPGFMIGTKVEQAGIIRHGAKMISAMSEATVPKLSV IVRKAYGAGLYAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYAKKIAELPEEERAA FISSKREEYKEDINIYRLASEMIIDAVIPANSLRDELAKRLKAYMTKEMTFTNRKHPV YPV*" /label="ldeE CDS" gene complement(1738655..1740190) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /label="ldeE gene" downshifts complement(1738667) /Source="Nicolas_upshifts" /id="D998" /incds=0 /nref=18 /ntot=38 /MaxReadThrough="1.74923" /MaxDrop="5.31437" /score="-1.4478995" /energy="-11.8" /TU="NA" /idTUdmin="U1477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1740201..1740983) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /EC_number="4.2.1.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglutaconyl-CoA hydratase (leucine degradation)" /protein_id="NP_389704.1" /db_xref="EnsemblGenomes-Gn:BSU18220" /db_xref="EnsemblGenomes-Tr:CAB13705" /db_xref="GOA:O34893" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG13457" /db_xref="UniProtKB/Swiss-Prot:O34893" /translation="MGDSILFTVKNEHMALITLNRPQAANALSAEMLRNLQMIIQEIE FNSNIRCVILTGTGEKAFCAGADLKERIKLKEDQVLESVSLIQRTAALLDALPQPVIA AINGSALGGGLELALACDLRIATEAAVLGLPETGLAIIPGAGGTQRLPRLIGRGKAKE FIYTGRRVTAHEAKEIGLVEHVTAPCDLMPKAEELAAAISANGPIAVRQAKFAINKGL ETDLATGLAIEQKAYEQTIPTKDRREGLQAFQEKRRAVYKGI*" /label="ldeF CDS" gene complement(1740201..1740983) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /label="ldeF gene" CDS complement(1741004..1741903) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /EC_number="4.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16330546, 19935659, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxymethylglutaryl-CoA lyase (leucine degradation)" /protein_id="NP_389705.1" /db_xref="EnsemblGenomes-Gn:BSU18230" /db_xref="EnsemblGenomes-Tr:CAB13706" /db_xref="GOA:O34873" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR013785" /db_xref="PDB:1YDO" /db_xref="SubtiList:BG13458" /db_xref="UniProtKB/Swiss-Prot:O34873" /translation="MPYPKKVTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSY IEITSFVHPKWIPALRDAIDVAKGIDREKGVTYAALVPNQRGLENALEGGINEACVFM SASETHNRKNINKSTSESLHILKQVNNDAQKANLTTRAYLSTVFGCPYEKDVPIEQVI RLSEALFEFGISELSLGDTIGAANPAQVETVLEALLARFPANQIALHFHDTRGTALAN MVTALQMGITVFDGSAGGLGGCPYAPGSSGNAATEDIVYMLEQMDIKTNVKLEKLLSA AKWIEEKMGKPLPSRNLQVFKSS*" /label="ldeG CDS" gene complement(1741004..1741903) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /label="ldeG gene" CDS complement(1741918..1742139) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type c: carrier" /codon_start=1 /transl_table=11 /product="methylcrotonyl-CoA carboxylase; biotinylated subunit (leucine degradation)" /protein_id="YP_003097733.1" /db_xref="EnsemblGenomes-Gn:BSU18239" /db_xref="EnsemblGenomes-Tr:CAX52627" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR011053" /db_xref="PDB:1Z6H" /db_xref="PDB:1Z7T" /db_xref="PDB:2B8F" /db_xref="PDB:2B8G" /db_xref="UniProtKB/Swiss-Prot:C0H419" /translation="MTVSIQMAGNLWKVHVKAGDQIEKGQEVAILESMKMEIPIVADR SGIVKEVKKKEGDFVNEGDVLLELSNSTQ*" /label="lgeHB CDS" gene complement(1741918..1742139) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /label="lgeHB gene" CDS complement(1742154..1743488) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /EC_number="6.4.1.4" /EC_number="6.3.4.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7915138, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin carboxylase for subunit LdeHB of methylcrotonyl-CoA carboxylase" /protein_id="NP_389706.1" /db_xref="EnsemblGenomes-Gn:BSU18240" /db_xref="EnsemblGenomes-Tr:CAB13707" /db_xref="GOA:O34544" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG13459" /db_xref="UniProtKB/Swiss-Prot:O34544" /translation="MFTKVLIANRGEIAMRIIRTCSRLGIKTVAVYSEADKDAPHTKA ATEAYLIGESRVSESYLNIERIIKTAKKAKADAIHPGYGLLSENSRFAERCKQENIVF IGPSPDIIAKMGSKIEARKAMEAAGVPVVPGVSESLGDIEAACRTASQIGYPVMLKAS AGGGGIGMQRVENEEALKKAYEGNKKRAADFFGDGSMYIEKVIEHARHIEVQLLADQH GHTVHLFERDCSVQRRHQKVIEEAPSPFVDDELRMKIGQTAVKAAKAIGYTNAGTIEF IVDQKQNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLRIAAGHTLTFSQKDIQRNGHA IEVRIYAEDPKTFFPSPGTITAFSLPDQKGVRHECAVAKDSTVTPFYDPMIAKMIVKG QTRTEAIEKLETALRDYRVEGIKTNLPLLIQAAATKAFKEGDVTTDFLKQHL*" /label="ldeHA CDS" gene complement(1742154..1743488) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /label="ldeHA gene" CDS complement(1743498..1745147) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /EC_number="6.2.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12535077, 15213221, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl-CoA synthetase" /protein_id="NP_389707.1" /db_xref="EnsemblGenomes-Gn:BSU18250" /db_xref="EnsemblGenomes-Tr:CAB13708" /db_xref="GOA:O31826" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13460" /db_xref="UniProtKB/Swiss-Prot:O31826" /translation="MAELIHSTIGRLLEQTADAYPDRDAVVYPDRNIRYTYAQFDSLC RQTAKGLMRMGIGKGDHVAIWASNISEWLAVQFATAKIGAVLVTVNTNYQAHELDYLL KQSDAAALIIMDSYRGTSYPDIVNSLIPELQEAKPGQLKSERYPFLKTLIYIGNKRLS GMYHWDDTEILAKTVTDAELEERMNSLDKDNVINMQYTSGTTGFPKGVMLTHFNVINN AANIAECMALTSQDRMCIPVPFFHCFGCVLGVLACVSVGAAMIPVQEFDPVTVLKTVE KEKCTVLHGVPTMFIAELHHPDFDAYDLSTLRTGIMAGSPCPSEVMKAVIERMGMKDI TIAYGQTEASPVITQTRANDSFIRRVETTGRALPHTEVKIVEPGTCQEVQRGMQGELC TRGYHVMKGYYKDKDATRKAINHDGWLFTGDLAVMDEDGYCRITGRLKDMLIRGGENI YPREIEEFLYQHPAVLDVQVVGVPDAKFGEEAAAWIKLKDGKSVSPDELKAYCKGKIA RHKIPRYVIFTDDYPMTASGKIQKYKLREKTIEMFNLSSSQ*" /label="ldeI CDS" gene complement(1743498..1745147) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /label="ldeI gene" promotor_no_box 1743547..1743647 /Source="Nicolas_upshift_promotors" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1743607 /Source="Nicolas_upshifts" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1745191..1746333) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /EC_number="1.3.8.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8655474, 17085570, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isovaleryl-CoA dehydrogenase (leucine degradation)" /protein_id="NP_389708.1" /db_xref="EnsemblGenomes-Gn:BSU18260" /db_xref="EnsemblGenomes-Tr:CAB13709" /db_xref="GOA:O34421" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG13461" /db_xref="UniProtKB/Swiss-Prot:O34421" /translation="MNFELTKEQQMVREMVKDFAKKEIAPHAEHVDQTGEFPMQTFKK MGELGLMGIPFPEEYGGSGGDTISYALAVEEVGKACGSTGLSYAAAVSLGASPLYYFG TEEQKQTHLTPLASGTALGSFGLTEPNAGSDAGGTQTKAISNGDEYVINGEKCWITNA SYARTVIVTAVTGKNKDGKNIISALIVPTDTPGLTITSPYDKMGVRGSNTAEILLEDV RVPAANLLGDPTKGFKQFLYTLDGGRISIAALAVGIAQAALDASLAYAKERKQFGQPI SSFQAIQFKLADMAMEIDLARQMVLKAAWLKDHNRPFTKEAAYAKLFASEMATRACNQ AIQIHGGSGYMKEYGVERMLRDAKLMEIGEGTSEIQRLVIARQLLK*" /label="ldeJ CDS" gene complement(1745191..1746333) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /label="ldeJ gene" promotor_-10 complement(1746352..1746370) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1746369) /Source="Nicolas_upshifts" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1746386..1746391) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1746424..1746729) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389709.1" /db_xref="EnsemblGenomes-Gn:BSU18270" /db_xref="EnsemblGenomes-Tr:CAB13710" /db_xref="GOA:O34356" /db_xref="InterPro:IPR020509" /db_xref="SubtiList:BG13468" /db_xref="UniProtKB/Swiss-Prot:O34356" /translation="MLTDPAEEAFLPNFLLLGAGTALVLCLVFFLYQKLDQSQFAVIK LGIWGSAVGLLMDTISLWNLPLIFPALSKGQVIAFTIWMVCAYCMYLLIPLILSHKK* " /label="ynzE CDS" gene complement(1746424..1746729) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /label="ynzE gene" CDS complement(1746719..1746892) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513961.1" /translation="MNMEAVFGHLPLLESEKLVLNKNKIEEKHVQDVFYVFISSLVRC HIIFCAVRRCCVD*" /label="conserved protein of unknown function CDS" gene complement(1746719..1746892) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /label="gene" CDS complement(1747000..1748532) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative exported glycoside hydrolase" /protein_id="NP_389710.1" /db_xref="EnsemblGenomes-Gn:BSU18280" /db_xref="EnsemblGenomes-Tr:CAB13711" /db_xref="InterPro:IPR003790" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG13462" /db_xref="UniProtKB/Swiss-Prot:O35015" /translation="MKVCQKSIVRFLVSLIIGTFVISVPFMANAQSDRELRAVWIASV LNIDWPSKKGLSVKEQKQEYIKLLDDVQKMGMNAVIVQIKPTADAFYPSAYGPWSEYL TGVQGKDPGYDPLAFMIEETHKRNLEFHAWFNPYRITMNHTDLNKLSEDHPARKHPDW VAAYGNQLYYHPGIPEARDFIVKGIEEVVKHYDIDAVHMDDYFYPYKIAGQEFPDQAQ YEQYGKDAFSNIDDWRRDNVNQLVKQINQTIKAAKPYVKFGISPFGVWRNAADDPTGS NTKAGVRNYDDLYADTRHWIQEGDIDYIAPQIYWSIGFNAAAYDVLADWWSNEVKNRP VHLYIGQAAYKINNNFDPPWSDPEEYVRQITLNRQLELVKGSMHFSLKDLNKNPLGIK DSLSTDLYSKPALVPQMPWLDNTAPKKPKLTKVTEDKNGNLLQIKDHPSNQKTKETAY YAIYRAEGKKQRTLLATQRKTHEQQTFLDNTADPNKKYTYYVTSADRLHNESKASKRT TK*" /label="yngK CDS" gene complement(1747000..1748532) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /label="yngK gene" downshifts complement(1747011) /Source="Nicolas_upshifts" /id="D999" /incds=0 /nref=7 /ntot=27 /MaxReadThrough="2.27934" /MaxDrop="4.41371" /score="9.43133612" /energy="-8" /TU="NA" /idTUdmin="U1478" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1748567..1748586) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1748567) /Source="Nicolas_upshifts" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1748599..1748608) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1748668..1749060) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28163698; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389711.1" /db_xref="EnsemblGenomes-Gn:BSU18290" /db_xref="EnsemblGenomes-Tr:CAB13712" /db_xref="GOA:O34506" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13463" /db_xref="UniProtKB/Swiss-Prot:O34506" /translation="MDRLSFLTFIMLILASYRLTHLIVFDKITEFIRKPFMKKKRIVD QNGHVDEKSVPASNFGYMLNCYWCAGVWCAILIGLGYLFLPRIAIPLIFILAIAGAQA ILETAVGVGVKLIDVLKSLQTMMNDKKS*" /label="yngL CDS" gene complement(1748668..1749060) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /label="yngL gene" downshifts complement(1748699) /Source="Nicolas_upshifts" /id="D1000" /incds=0 /nref=2 /ntot=18 /MaxReadThrough="0.581539999999999" /MaxDrop="2.96298" /score="5.25915686" /energy="-11.4" /TU="NA" /idTUdmin="U1479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1749088..1749099) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1749095) /Source="Nicolas_upshifts" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1749113..1749119) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1749167,1749174) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs10" N_region 1749168..1749173 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs10" S_feature complement(<1749174..1749279) /Source="Nicolas_S_feature" /locus_tag="new_1997958_1998066_c" /HighExp="T1.30H, T1.0H, T0.30H, S1, M0t90, T2.30H, LPhT, C90, LoTm, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S679" promotor_-10 complement(1749264..1749283) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1749279) /Source="Nicolas_upshifts" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1749297..1749304) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1749553..1751028) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /EC_number="3.4.16.4" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733705, 9864321, 11160090, 14731276, 17582436, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 9864321, 11160090, 14731276, 17582436, 19758330; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase" /protein_id="NP_389717.1" /db_xref="EnsemblGenomes-Gn:BSU18350" /db_xref="EnsemblGenomes-Tr:CAB13718" /db_xref="GOA:P39844" /db_xref="InterPro:IPR000667" /db_xref="InterPro:IPR012338" /db_xref="PDB:1W5D" /db_xref="PDB:2J9P" /db_xref="SubtiList:BG10969" /db_xref="UniProtKB/Swiss-Prot:P39844" /translation="MKKSIKLYVAVLLLFVVASVPYMHQAALAAEKQDALSGQIDKIL ADHPALEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFT TEVRTDGTLKGKKLNGNLYLKGKGDPTLLPSDFDKMAEILKHSGVKVIKGNLIGDDTW HDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTVIVEVTPNQKEGEEPAVSVS PKTDYITIKNDAKTTAAGSEKDLTIEREHGTNTITIEGSVPVDANKTKEWISVWEPAG YALDLFKQSLKKQGITVKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAE VLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQ LLYDIQDQSWFSAYLNSLPVAGNPDRMVGGTLRNRMKGTPAQGKVRAKTGSLSTVSSL SGYAETKSGKKLVFSILLNGLIDEEDGKDIEDQIAVILANQ*" /label="dacC CDS" gene complement(1749553..1751028) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /label="dacC gene" downshifts complement(1749565) /Source="Nicolas_upshifts" /id="D1003" /incds=0 /nref=126 /ntot=224 /MaxReadThrough="1.56173" /MaxDrop="5.81468" /score="20.5621533" /energy="-10.2" /TU="NA" /idTUdmin="U1484" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(1751062..1752039) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /EC_number="5.1.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9733705, 12753898, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 12753898, 19758330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldose 1-epimerase" /protein_id="NP_389718.1" /db_xref="EnsemblGenomes-Gn:BSU18360" /db_xref="EnsemblGenomes-Tr:CAB13719" /db_xref="GOA:P39840" /db_xref="InterPro:IPR008183" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR014718" /db_xref="PDB:3MWX" /db_xref="PDB:4BZE" /db_xref="PDB:4BZF" /db_xref="PDB:4BZG" /db_xref="PDB:4BZH" /db_xref="SubtiList:BG10253" /db_xref="UniProtKB/Swiss-Prot:P39840" /translation="MANFIEKITYLGTPAIKAGNEHLEMIVVPEWGSNVISLVDKTTN VQLLREPETAESFHDTPTLYGIPILFPPNRISDGTFSFRGRTYHFDINEKDKHNHLHG FLYHEKWNVVTTKQTDEGVIVETEIDLSELPHVQKQFPHHAVVRMTYTIKENTLFKHA TVMNKGKEAFPWGIGYHTTFIFPAESSLFSLTADQQWELDERLLPTGKLMDVPYKEAL HEGMDLRHKQLDDVFLSSYQKRGGENQAVIYHQHAHISIIYKADEQFKHWVVYNADGK QGYLCPEPYTWVTNAVNLDLPSSLTGLQVLEPGEETTAKSSITIELNHQ*" /label="galM CDS" gene complement(1751062..1752039) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /label="galM gene" promotor_-10 complement(1752068..1752086) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1752080) /Source="Nicolas_upshifts" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1752098..1752106) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1752173..1753564) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven efflux transporter" /protein_id="NP_389719.2" /db_xref="EnsemblGenomes-Gn:BSU18370" /db_xref="EnsemblGenomes-Tr:CAB13720" /db_xref="GOA:O34474" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13548" /db_xref="UniProtKB/Swiss-Prot:O34474" /translation="METSQEPLVTQKKSKPSVWRSMSLFLVPLLLSNVLQSVGQLVGM MAVGRWLGVDAVAAVSSFFPLFFLLISFTIGIGSGSSILIGQAYGAKNEERLKAVVGT TLTFTFLLGVVLAVIGSIFTLDILRLMGTPENVIHVSANYARILFYAMPFMFLYFAYT TFLRGTGDSKTPFYTLIVSTVINIALLPVLILGMFGFPKLGIYGSAYATVISTIATFL VLMVYLRKRKHPLQFDKTVRRYLKMDKELLVLLLRLGVPASINMILVSLSEIAVISFV NHYGSNATAAYGVVNQVASYVQMPAVSLGIAVSIFAAQSIGANEFDRLKQVIRVGIWL NYIIGGVLIILIYVFSHQILSLFLTEQETLYIAHRLLMITLWSYLLFGNAQIISATMR ASGTVLWPTVISIFAIWGVEVPVAFVLSHYTKLEILGVWVGYPAAFAVSLLLIYGYYQ FVWKKKQITRLIQ*" /label="yoeA CDS" gene complement(1752173..1753564) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /label="yoeA gene" downshifts complement(1752187) /Source="Nicolas_upshifts" /id="D1004" /incds=0 /nref=74 /ntot=213 /MaxReadThrough="2.12119" /MaxDrop="5.14152" /score="31.8413544" /energy="-12.3" /TU="NA" /idTUdmin="U1486" /TUdmin=2 /isTUend="TRUE" /label="downshifts" downshifts 1752333 /Source="Nicolas_upshifts" /id="D1005" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="1.76262" /MaxDrop="3.63403" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1485" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" promotor_-35 1753354..1753360 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-35" promotor_-10 1753374..1753392 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-10" S_feature 1753385..1753718 /Source="Nicolas_S_feature" /locus_tag="new_2002172_2002505" /HighExp="M9-stat, Etha, Gly, S8, Sw, S7, B60, S6, Salt, C30" /AntisenseName="yoeA" /AntisenseCor="9.0133358617756607E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S680" upshifts 1753385 /Source="Nicolas_upshifts" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="upshifts" S_feature complement(1753565..1753669) /Source="Nicolas_S_feature" /locus_tag="new_2002352_2002456_c" /HighExp="S8, LBGstat, Etha, Cold, S7, T-1.40H, S2, C90, nit, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.456" /TUlongSig="NA" /TUlongPSig="NA" /label="S681" promotor_no_box complement(1753629..1753729) /Source="Nicolas_upshift_promotors" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1753669) /Source="Nicolas_upshifts" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1753691..1753696 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1753712..1753730 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1753720 /Source="Nicolas_upshifts" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1753778..1753785 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1753798..1753817 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1753801 /Source="Nicolas_upshifts" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" CDS 1753850..1754395 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17483219, 17581128, 18761694, 22720735, 23091053" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483219, 17581128, 18761694, 22720735, 23091053; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of DL-endopeptidases involved in cell-separation" /protein_id="NP_389720.2" /db_xref="EnsemblGenomes-Gn:BSU18380" /db_xref="EnsemblGenomes-Tr:CAB13721" /db_xref="InterPro:IPR031841" /db_xref="PDB:2RSX" /db_xref="SubtiList:BG13549" /db_xref="UniProtKB/Swiss-Prot:O34841" /translation="MKKCLLFLTTIALILSLSTNAFAKNTSGDLSQKQALQLALSARE HFWNTMSGHNPKVKKAVCPSGTFEYQNLQYVYMCSDLGTKAKAVNYLTPIFTKTAIEK GFKDYHFTVSKGKLAVPIGDGDNLLNWKKSTAKLISKKGSTITYEFTVPTLDGSPSAK RKVTFVKENKKWKVNQFDAVI*" /label="iseA CDS" gene 1753850..1754395 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /label="iseA gene" downshifts 1754379 /Source="Nicolas_upshifts" /id="D1006" /incds=0 /nref=164 /ntot=264 /MaxReadThrough="4.38689" /MaxDrop="8.27665" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA complement(1754489..1754561) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg1 tRNA" gene complement(1754489..1754561) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /label="trnSL-Arg1 gene" downshifts complement(1754587) /Source="Nicolas_upshifts" /id="D1007" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="1.99821" /MaxDrop="3.03097" /score="3.94141467" /energy="-15.1" /TU="NA" /idTUdmin="U1489" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1754614..1755159) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacteriophage integrase" /protein_id="NP_389721.2" /db_xref="EnsemblGenomes-Gn:BSU18390" /db_xref="EnsemblGenomes-Tr:CAB13722" /db_xref="GOA:O35009" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR013762" /db_xref="SubtiList:BG13550" /db_xref="UniProtKB/Swiss-Prot:O35009" /translation="MHIVQPIRSLEKIQEVKQYLLNKNKRDYFLFIFGINSALRISDI LPLQVKDVQNKDHLWATESKTKKKRKILILESLKQEIYEYTKDMKENEYLFKSVRTRK PISRIQAYRILREAAAACGLEEIGTHTLRKTFGYHFYQRTKDIAELQRILNHSSPSIT MRYIGIDEDTTRAAYKVFGGL*" /label="yoeC CDS" gene complement(1754614..1755159) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /label="yoeC gene" promotor_-10 complement(1755199..1755218) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1755213) /Source="Nicolas_upshifts" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1755232..1755239) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1755475..1755705) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16880568; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excisionase" /protein_id="NP_389722.1" /db_xref="EnsemblGenomes-Gn:BSU18400" /db_xref="EnsemblGenomes-Tr:CAB13723" /db_xref="GOA:O34555" /db_xref="InterPro:IPR010093" /db_xref="SubtiList:BG13551" /db_xref="UniProtKB/Swiss-Prot:O34555" /translation="MYLTIEETAEYTNLSEDYIKSLVLEGKIRAVHDGEQFLIYKEQF KTHLEQLENYKALVQEILNEPIPEDIDVKDED*" /label="yoeD CDS" gene complement(1755475..1755705) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /label="yoeD gene" downshifts complement(1755489) /Source="Nicolas_upshifts" /id="D1008" /incds=0 /nref=193 /ntot=248 /MaxReadThrough="0.81591" /MaxDrop="5.75977" /score="19.8797745" /energy="-8.6" /TU="NA" /idTUdmin="U1490" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1755731..1755750) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1755743) /Source="Nicolas_upshifts" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1755762..1755768) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1755797..1755816) /Source="Nicolas_upshift_promotors" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1755807) /Source="Nicolas_upshifts" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1755820..1755827 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1755841..1755860 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1755845 /Source="Nicolas_upshifts" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="upshifts" CDS 1755890..1757653 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /EC_number="2.3.2.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8763966, 23335395, 24279353, 26370226, 28120195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763966, 23335395, 24279353, 26370226, 28120195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound gamma-glutamyltranspeptidase" /protein_id="NP_389723.1" /db_xref="EnsemblGenomes-Gn:BSU18410" /db_xref="EnsemblGenomes-Tr:CAB13724" /db_xref="GOA:P54422" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="PDB:2V36" /db_xref="PDB:3A75" /db_xref="PDB:3WHQ" /db_xref="PDB:3WHR" /db_xref="PDB:3WHS" /db_xref="SubtiList:BG11838" /db_xref="UniProtKB/Swiss-Prot:P54422" /translation="MKRTWNVCLTALLSVLLVAGSVPFHAEAKKPPKSYDEYKQVDVG KDGMVATAHPLASEIGADVLKKGGNAIDAAVAIQFALNVTEPMMSGIGGGGFMMVYDG KTKDTTIIDSRERAPAGATPDMFLDENGKAIPFSERVTKGTAVGVPGTLKGLEEALDK WGTRSMKQLITPSIKLAEKGFPIDSVLAEAISDYQEKLSRTAAKDVFLPNGEPLKEGD TLIQKDLAKTFKLIRSKGTDAFYKGKFAKTLSDTVQDFGGSMTEKDLENYDITIDEPI WGDYQGYQIATTPPPSSGGIFLLQMLKILDHFNLSQYDVRSWEKYQLLAETMHLSYAD RASYAGDPEFVNVPLKGLLHPDYIKERQQLINLDQVNKKPKAGDPWKYQEGSANYKQV EQPKDKVEGQTTHFTVADRWGNVVSYTTTIEQLFGTGIMVPDYGVILNNELTDFDAIP GGANEVQPNKRPLSSMTPTILFKDDKPVLTVGSPGGATIISSVLQTILYHIEYGMELK AAVEEPRIYTNSMSSYRYEDGVPKDVLSKLNGMGHKFGTSPVDIGNVQSISIDHENGT FKGVADSSRNGAAIGINLKRK*" /label="ggt CDS" gene 1755890..1757653 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /label="ggt gene" downshifts 1757634 /Source="Nicolas_upshifts" /id="D1009" /incds=0 /nref=24 /ntot=49 /MaxReadThrough="1.41914" /MaxDrop="5.80171" /score="3.23845421" /energy="-10.4" /TU="NA" /idTUdmin="U1492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1757754..1758611) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17526699" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_389724.1" /db_xref="EnsemblGenomes-Gn:BSU18420" /db_xref="EnsemblGenomes-Tr:CAB13725" /db_xref="GOA:O34685" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13552" /db_xref="UniProtKB/Swiss-Prot:O34685" /translation="MESGDLKIFQAVAREGSITKAAQMLNYVQSNVTARVHNLEEDLN IRLFHRTNRGMKLTAAGENLLQYADQVLSLLDQAEKSTRMSRQPKGPLRIGSLETMAV THLPEHAASFLRRFPEVDLSVNTADTHHLIQQVLDHKVDGAFVYGPVEHAAVRQLHVS HDELVLISSREGTAEDMLQQPMLFFGAGCSHRDRVKRLLEEAGIHNQKIIEFGTLEAI IKGVSAGMGTALLPKSAVDGSEHRTNVWIHQLPPSYQDLEIVFIYRKDFFITSAFQTF LDEINEMKR*" /label="ftsR CDS" gene complement(1757754..1758611) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /label="ftsR gene" promotor_-10 complement(1758657..1758676) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1758677) /Source="Nicolas_upshifts" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1758690..1758697) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1758739..1759728 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 23873705; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389725.1" /db_xref="EnsemblGenomes-Gn:BSU18430" /db_xref="EnsemblGenomes-Tr:CAB13726" /db_xref="GOA:O35017" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13553" /db_xref="UniProtKB/Swiss-Prot:O35017" /translation="MKAVIHNGKAGLLGLSVQDVPSTKPGYGEVKVKLKSAGLNHRDL FLMKNKSEQDPHMILGSDGAGIIEEIGEGVKNVTVQTEVVIFPTLNWDLTENVPPVPE ILGGPSDGTLAEYVIIPSQNAIKKPAYLSWEEAGVLPLSALTAYRALFTKGQLKKGEH LLIPGIGSGVATYALFMAKAIGATVSVTSRSEEKRKKALKLGADYAFDSYSNWDEQLQ GKKIDVVLDSIGPALFSEYFRHVKPNGRIVSFGASSGDNLSFPVRSLFFPQVNVLGTS MGSGEEFQAMLAFIDKHKLRPVIDRIYPLEKACEAYKRMQEGRQFGNIGIVME*" /label="yogA CDS" gene 1758739..1759728 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /label="yogA gene" S_feature complement(1758795..1759753) /Source="Nicolas_S_feature" /locus_tag="new_2007582_2008540_c" /HighExp="T-4.40H, T-5.40H, Glu, GM 45, Glucon, GM-0.1, Gly, GM-0.2, UNK1, GM 90" /AntisenseName="yogA" /AntisenseCor="-0.49303153269799599" /AntisenseRegPval="-17.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S682" CDS complement(1759785..1761266) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3011766, 10651638, 11029411, 27223617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3011766, 10651638, 11029411, 27223617; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (small subunit, NADP-dependent)" /protein_id="NP_389726.2" /db_xref="EnsemblGenomes-Gn:BSU18440" /db_xref="EnsemblGenomes-Tr:CAB13727" /db_xref="GOA:O34399" /db_xref="InterPro:IPR006005" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR028261" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12594" /db_xref="UniProtKB/Swiss-Prot:O34399" /translation="MGKPTGFMEIKREKPAERDPLTRLKDWKEYSAPFSEEASKRQGA RCMDCGTPFCQIGADINGFTSGCPIYNLIPEWNDLVYRGRWKEALERLLKTNNFPEFT GRVCPAPCEGSCTLAISDPAVSIKNIERTIIDKGFENGWIQPRIPKKRTGKKVAIVGS GPAGLASADQLNQAGHSVTVFERADRAGGLLTYGIPNMKLEKGIVERRIKLLTQEGID FVTNTEIGVDITADELKEQFDAVILCTGAQKQRDLLIEGRDSKGVHYAMDYLTLATKS YLDSNFKDKQFIDAKGKDVIVIGGGDTGADCVATALRQKAKSVHQFGKHPKLPPARTN DNMWPEQPHVFTLEYAYEEAEAKFGRDPREYSIQTTKMVADKNGKLKELHTIQMEKVK NEHGKYEFRELPGTEKVWPAQLVFIAIGFEGTEQPLLKQFGVNSVNNKISAAYGDYQT NIDGVFAAGDARRGQSLIVWAINEGREVAREVDRYLMGSSVLP*" /label="gltB CDS" gene complement(1759785..1761266) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /label="gltB gene" downshifts complement(1759798) /Source="Nicolas_upshifts" /id="D1010" /incds=0 /nref=247 /ntot=279 /MaxReadThrough="3.292" /MaxDrop="7.52772" /score="10.4717228" /energy="-6.5" /TU="U1495" /idTUdmin="U1495" /TUdmin="-570" /isTUend="FALSE" /label="downshifts" CDS complement(1761283..1765845) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (large subunit, NADP-dependent)" /protein_id="NP_389727.2" /db_xref="EnsemblGenomes-Gn:BSU18450" /db_xref="EnsemblGenomes-Tr:CAB13728" /db_xref="GOA:P39812" /db_xref="InterPro:IPR002489" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR006982" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR036485" /db_xref="SubtiList:BG10811" /db_xref="UniProtKB/Swiss-Prot:P39812" /translation="MTYNQMPKAQGLYRPEFEHDACGIGLYAHLKGKQTHDIVKQGLK MLCQLDHRGGQGSDPDTGDGAGLLVQIPDAFFRKECKNINLPEKERYGVGMVFFSQKE DERKKIEKQINALIEQEGQVVLGWRTVPVNVGKIGTVAQKSCPFVRQVFIGASSDLKD NLSFERKLYVIRKQAENWGVTEGLDFYFASLSSQTIVYKGLLTPEQVDAFYSDLQDEA FVSAFALVHSRFSTNTFPTWERAHPNRYLVHNGEINTLRGNINWMRAREQQFVSESFG EDLNKILPILNADGSDSSILDNAFEFFVMAGRKPAHTAMMLIPEPWTENTHMSKEKRA FYEYHSSLMEPWDGPTAISFTDGKQIGAILDRNGLRPARYYVTKDDYIIFSSEVGVIE VEQENVLYKNRLEPGKMLLIDLEEGRIISDEEVKTQIATEYPYQKWLEEELVQVNPDP ESREEEQFSDLLTRQKAFGYTYEDIQKYLIPVIKEGKDPLGSMGNDAPLAVLSDRAQS LFNYFKQLFAQVTNPPIDAIREQLVTSTMTWLGAEGDLLHPSERNVRRIKLYTPVLSN EQFYALKTIVHPDLKSQKIDVLFSEDLERGLKDMFTQAEKAISQGVSLLILSDKKMNE RLTPIPPLLAVSALHQHLIRKGLRTKVSIIVESGEAREVHHFAALIGYGADAINPYLA YATYKQEIDEGRLDISYEEAVSKYGKSITEGVVKVMSKMGISTVQSYRGAQIFEAVGI SRDVIDRYFSGTASQLGGIDLQTIAEEAQRRHREAYQDDYSKTLEPGSDFQWRNGGEH HAFNPKTIHTLQWACRRNDYNLFKQYTKAADEERIGFLRNLFAFDGNRKPLKLEEVES AESIVKRFKTGAMSFGSLSKEAHEALAIAMNRLGGKSNSGEGGEDPKRFVPDENGDDR RSAIKQIASGRFGVKSHYLVNADELQIKMAQGAKPGEGGQLPGNKVYPWVADVRGSTP GVGLISPPPHHDIYSIEDLAQLIHDLKNANRDARISVKLVSKAGVGTIAAGVAKATAD VIVISGYDGGTGASPKTSIKHTGLPWELGLAEAHQTLMLNGLRDRVVLETDGKLMTGR DVVMAALLGAEEFGFATAPLVVLGCVMMRACHLDTCPVGVATQNPELRKKFMGDPDHI VNYMLFIAEEVREYMAALGFKTFDEMIGRTDVLHASERAKEHWKASQLDLSTLLYQPE GVRTFQSPQNHKIDQSLDITTILPAVQEAIESGKEADISIEINNTNRVAGTITGSEIS KRYGEEGLPEDTIKLHFTGSAGQSFGAFVPKGMTLYLDGDSNDYVGKGLSGGKIIVKS SEGFNSASDDNVIIGNVAFYGATSGEAYINGRAGERFAVRNSGVNVVVEGIGDHGCEY MTGGSVVVLGDVGKNFAAGMSGGIAYVLTEDVKAFKRKCNLEMILFESLEDEKEIQQI KAMLERHTAYTNSQKAEDLLDQWEDSVKKFVKVIPKNYKQMLASIEEQKAAGLSDEEA IMFAFEANTKPKQNTAASGQKQAVVQ*" /label="gltA CDS" gene complement(1761283..1765845) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /label="gltA gene" promotor_no_box 1764306..1764406 /Source="Nicolas_upshift_promotors" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1764366 /Source="Nicolas_upshifts" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1765846..1765917) /Source="Nicolas_S_feature" /locus_tag="new_2014633_2014704_c" /HighExp="SMM, T-5.40H, HiOs, MG 15, Glu, T-4.40H, MG 150, MG 60, UNK1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S683" promotor_-10 complement(1765897..1765916) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1765914..1765921 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1765917) /Source="Nicolas_upshifts" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1765931..1765938) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1765933 /Source="Nicolas_upshifts" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1765936..1765955 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1765992..1766894 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2548995, 15150225, 17134717, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2548995, 15150225, 17134717, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family) (GltC-glutamate)" /protein_id="NP_389728.2" /db_xref="EnsemblGenomes-Gn:BSU18460" /db_xref="EnsemblGenomes-Tr:CAB13729" /db_xref="GOA:P20668" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10810" /db_xref="UniProtKB/Swiss-Prot:P20668" /translation="MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELN VTLFEREGRNIKLTPIGKEFLIHVKTAMKAIDYAKEQIDEYLDPHRGTVKIGFPTSLA SQLLPTVISAFKEEYPHVEFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKI LFTEKIYALVPLNHPLAKQKTVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLV STEGEDLDAIKGLVSAGMGVTLLPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNR ELAPSANDFYEFVIQFFSKLEQYQ*" /label="gltC CDS" gene 1765992..1766894 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /label="gltC gene" downshifts 1766874 /Source="Nicolas_upshifts" /id="D1011" /incds=0 /nref=104 /ntot=241 /MaxReadThrough="2.84467" /MaxDrop="3.98111" /score="22.3639229" /energy="-13.6" /TU="NA" /idTUdmin="U1496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1766946..1768061) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /EC_number="2.7.2.11" /function="16.8: Protect" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:11418582, 15804359, 21784929, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 15804359, 21784929, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389729.1" /db_xref="EnsemblGenomes-Gn:BSU18470" /db_xref="EnsemblGenomes-Tr:CAB13740" /db_xref="GOA:O07509" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG12658" /db_xref="UniProtKB/Swiss-Prot:O07509" /translation="MTPDTSMKRVVVKIGSSSLTSLHGEISIRKLEALVDQVVKLKDA GYEVILVSSGAVAAGYRKLGFIQRPEKLPEKQASASIGQGLLMEAYSKLFLAHGYVAS QILITRSDFSDEYRYNNVRNTMNVLLERGIIPIINENDTVTVNRLKFGDNDTLAAKVA GLIDADMLVILSDIDGLYDGNPRTNPEAKKIQRVSEITPDIEACAGDTGSIVGTGGMR SKLDAFKIVMASGIKGFLGQADAGDILYHAVHEQAEGTYFEAEGTLPLNQKEQWIAFN SGPEGEMILSDDCSRKITNGQSSLYLDGVQKIKGKFKSGSVVRLMDSKGTEIGLGIVN YSSVQLQEPEKKKELTNRALIDQEAFVCHVDFSLPVN*" /label="proJ CDS" gene complement(1766946..1768061) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /label="proJ gene" CDS complement(1768058..1768951) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21784929, 22139509, 25344233, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21784929, 22139509, 25344233, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase" /protein_id="NP_389730.2" /db_xref="EnsemblGenomes-Gn:BSU18480" /db_xref="EnsemblGenomes-Tr:CAB13741" /db_xref="GOA:P0CI77" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11049" /db_xref="UniProtKB/Swiss-Prot:P0CI77" /translation="MRTKKRTKEMLPIFDQKKVAFIGAGSMAEGMISGIVRANKIPKQ NICVTNRSNTERLTELELQYGIKGALPNQLCIEDMDVLILAMKPKDAENALSSLKSRI QPHQLILSVLAGITTSFIEQSLLNEQPVVRVMPNTSSMIGASATAIALGKYVSEDLKK LAEALLGCMGEVYTIQENQMDIFTGIAGSGPAYFYYLMEFIEKTGEEAGLDKQLSRSI GAQTLLGAAKMLMETGEHPEILRDNITSPNGTTAAGLQALKKSGGGEAISQAIKHAAK RSKEISEDIEKTAAPLSGVIK*" /label="proH CDS" gene complement(1768058..1768951) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /label="proH gene" promotor_-10 complement(1768956..1768975) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1768964 /Source="Nicolas_upshifts" /id="D1012" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="1.17009" /MaxDrop="3.27004" /score="-0.988973561" /energy="-13.3" /TU="NA" /idTUdmin="U1496" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" upshifts complement(1768974) /Source="Nicolas_upshifts" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1768989..1768995) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1769004..1769022) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1769022) /Source="Nicolas_upshifts" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1769038..1769043) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1769099..1769467) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11313334, 15657033, 16822523, 17376071, 17521668, 24946150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11313334, 15657033, 16822523, 17376071, 17521668, 24946150; Product type f : factor" /codon_start=1 /transl_table=11 /product="replication terminator protein" /protein_id="NP_389731.1" /db_xref="EnsemblGenomes-Gn:BSU18490" /db_xref="EnsemblGenomes-Tr:CAB13742" /db_xref="GOA:P0CI76" /db_xref="InterPro:IPR003432" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1BM9" /db_xref="PDB:1F4K" /db_xref="PDB:1J0R" /db_xref="PDB:2DPD" /db_xref="PDB:2DPU" /db_xref="PDB:2DQR" /db_xref="PDB:2EFW" /db_xref="SubtiList:BG10738" /db_xref="UniProtKB/Swiss-Prot:P0CI76" /translation="MKEEKRSSTGFLVKQRAFLKLYMITMTEQERLYGLKLLEVLRSE FKEIGFKPNHTEVYRSLHELLDDGILKQIKVKKEGAKLQEVVLYQFKDYEAAKLYKKQ LKVELDRCKKLIEKALSDNF*" /label="rtp CDS" gene complement(1769099..1769467) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /label="rtp gene" promotor_-10 complement(1769502..1769520) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-10" upshifts complement(1769525) /Source="Nicolas_upshifts" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="upshifts" S_feature complement(1769527..1769646) /Source="Nicolas_S_feature" /locus_tag="new_2018314_2018433_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, LBGtran, LoTm, LBGexp, G180, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S684" promotor_-35 complement(1769532..1769540) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-35" promotor_-10 complement(1769638..1769657) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1769646) /Source="Nicolas_upshifts" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1769648..1769744) /Source="Nicolas_S_feature" /locus_tag="new_2018435_2018531_c" /HighExp="Etha, dia15, LBGtran, LoTm, dia5, H2O2, LBGexp, M0t45, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S685" promotor_-35 complement(1769672..1769679) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1769767..1770483) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxido-reductase" /protein_id="NP_389732.1" /db_xref="EnsemblGenomes-Gn:BSU18500" /db_xref="EnsemblGenomes-Tr:CAB13743" /db_xref="GOA:P14802" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11048" /db_xref="UniProtKB/Swiss-Prot:P14802" /translation="MQSLQHKTALITGGGRGIGRATALALAKEGVNIGLIGRTSANVE KVAEEVKALGVKAAFAAADVKDADQVNQAVAQVKEQLGDIDILINNAGISKFGGFLDL SADEWENIIQVNLMGVYHVTRAVLPEMIERKAGDIINISSTAGQRGAAVTSAYSASKF AVLGLTESLMQEVRKHNIRVSALTPSTVASDMSIELNLTDGNPEKVMQPEDLAEYMVA QLKLDPRIFIKTAGLWSTNP*" /label="yoxD CDS" gene complement(1769767..1770483) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /label="yoxD gene" downshifts complement(1769789) /Source="Nicolas_upshifts" /id="D1013" /incds=0 /nref=109 /ntot=217 /MaxReadThrough="4.9568" /MaxDrop="5.08605" /score="27.1231718" /energy="-7.5" /TU="U1501" /idTUdmin="U1500" /TUdmin="-594" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1770521..1770540) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1770530) /Source="Nicolas_upshifts" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1770556..1770559) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1770584..1770590 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1770604..1770622 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1770609 /Source="Nicolas_upshifts" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="upshifts" CDS 1770634..1770939 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16513748, 17598888; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="transition-dependent and sulfur-related metabolism protein" /protein_id="NP_389733.1" /db_xref="EnsemblGenomes-Gn:BSU18510" /db_xref="EnsemblGenomes-Tr:CAB13744" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG11047" /db_xref="UniProtKB/Swiss-Prot:P28670" /translation="MIIVYISLAVLAVSIIFLGVTVIQNKKKIDPALKELSSVTQAMQ KQIEGLKTETELLTQKQKKIQQDVQIKKYTLQQTAAEVKEVPQAVKEVWQAGHFNSR* " /label="yoxC CDS" gene 1770634..1770939 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /label="yoxC gene" downshifts 1770923 /Source="Nicolas_upshifts" /id="D1014" /incds=0 /nref=6 /ntot=88 /MaxReadThrough="5.31272" /MaxDrop="3.8396" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin="-1473" /isTUend="FALSE" /label="downshifts" CDS 1771010..1771780 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 17598888, 19703276" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389734.1" /db_xref="EnsemblGenomes-Gn:BSU18520" /db_xref="EnsemblGenomes-Tr:CAB13745" /db_xref="InterPro:IPR020530" /db_xref="InterPro:IPR036895" /db_xref="SubtiList:BG11046" /db_xref="UniProtKB/Swiss-Prot:P28671" /translation="MIINRSCLKEFAEKVHFLPSSLTKSDLLTDPFRLHQENELGIYY SPHNEFINRDASLVIAGITPGFSQMKTAYETAAESLLQGGTLEQMAVDTKIAAGFSGS MRHNLITMLDLCGLPQAFGIQSAAKLFGELRHMLHTTSVIKYPVFIQQKNYTGYKPAI THSPILSTYAFGHFPAELNHVTGPALLIPLGKAAETVCETLIRQHSLQNLICLNGFPH PSGANGHRLKQFSKNKEQLERQIRSFAALVDFAIEKRK*" /label="yoxB CDS" gene 1771010..1771780 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /label="yoxB gene" promotor_-35 1771762..1771769 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1771781 /Source="Nicolas_upshifts" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1771784..1771803 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1771824..1772357 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 11717291, 17598888; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389735.2" /db_xref="EnsemblGenomes-Gn:BSU18530" /db_xref="EnsemblGenomes-Tr:CAB13746" /db_xref="GOA:O34569" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13472" /db_xref="UniProtKB/Swiss-Prot:O34569" /translation="MFPILETDRLILRQITDQDAEAIFACFSNDEVTRYYGLENMESI EQAISMIQTFAALYQEKRGIRWGIERRDTKELIGTIGFHALAQKHRRAEIGYEIIPEH WRNGFASEVISKVVSYGFSALGLSRIGAVVFTDNEASNRLLLKMGFQKEGVLRQYMYQ NGTPYDTNVYSIVKPRE*" /label="yoaA CDS" gene 1771824..1772357 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /label="yoaA gene" S_feature 1772358..1772443 /Source="Nicolas_S_feature" /locus_tag="new_2021145_2021230" /HighExp="Salt, Sw, B60, LoTm, B36, M9-stat, BC, Lbstat, HiTm, Etha" /AntisenseName="yoaB" /AntisenseCor="-0.17521117067018899" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S686" downshifts 1772400 /Source="Nicolas_upshifts" /id="D1015" /incds=0 /nref=6 /ntot=100 /MaxReadThrough="4.32682" /MaxDrop="3.67936" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1772436..1773680) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12193636, 15849754, 16513748, 16850406, 28546427; Product type t : transporter" /codon_start=1 /transl_table=11 /product="negatively charged metabolite transporter" /protein_id="NP_389736.1" /db_xref="EnsemblGenomes-Gn:BSU18540" /db_xref="EnsemblGenomes-Tr:CAB13747" /db_xref="GOA:O34864" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13473" /db_xref="UniProtKB/Swiss-Prot:O34864" /translation="MLDKIGIPKRLAWGFLGVVLFMMGDGLEQGWLSPFLIENGLTVQ QSASIFSIYGIALAIASWFSGVCLEAFGAKRTMFMGLLFYVIGTAAFIVFGFEQLNLP VMYVTYFVKGLGYPLFAYSFLTWVIYRTPQSKLSTAVGWFWIAYCLGMFVFGAWYSSY AIKAFGYLNTLWSSIFWVCLGAFFALFINKDRFEKKKRKRSETAEELLKGVTILFTNP RVLTGGIIRIINSIGTYGFPVFLPMHMAQHGISTNVWLQIWGTIFLGNIVFNLIFGIV GDKFGWKNTVIWFGGVGCGIFTVLLYYAPVFSGGSLAVVSVIGFIWGGLLAGYVPIGA IVPTVAGKDKGAAMSVLNLAAGLSAFVGPALAWLFIGLVGAQGVVWIFAALYLASAVL TKCIHIPEEKAVKEETSPQYAS*" /label="yoaB CDS" gene complement(1772436..1773680) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /label="yoaB gene" S_feature 1772445..1773184 /Source="Nicolas_S_feature" /locus_tag="new_2021232_2021971" /HighExp="LoTm, Salt, Sw, S6, Etha, M9-stat, LPhT, B60, T2.0H, T2.30H" /AntisenseName="yoaB" /AntisenseCor="-0.18536963552729299" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S687" downshifts complement(1772450) /Source="Nicolas_upshifts" /id="D1016" /incds=0 /nref=32 /ntot=113 /MaxReadThrough="2.59019" /MaxDrop="4.97477" /score="29.0246554" /energy="-12.5" /TU="NA" /idTUdmin="U1504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1773681..1773773) /Source="Nicolas_S_feature" /locus_tag="new_2022468_2022560_c" /HighExp="MG 10, MG 5, BMM, MG t5, MG 15, GM 25, HiTm, UNK1, GM 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S688" CDS complement(1773774..1775237) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10094622, 12193636, 16850406, 18039762, 21749987, 27795321, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxylated metabolite kinase" /protein_id="NP_389737.1" /db_xref="EnsemblGenomes-Gn:BSU18550" /db_xref="EnsemblGenomes-Tr:CAB13748" /db_xref="GOA:O34861" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG13474" /db_xref="UniProtKB/Swiss-Prot:O34861" /translation="MKKQKGYLVFDIGTGNARVAVVSVTGSVLTVEREDIEYSTETLY PDSRYFSPQVLWKQVMNLAKRALSRSCDIDIIGLTSTSQRQGIVLIDQNGNPFLGLPN IDNRGREWEAGIPDWEEIYSSTGRLPTALFSALKLYGLKQRQPSLWEKTASFTSISDW VTYQLSGILTYEPSQATETLLFDVKQNTWSEEMCDIFGFSPSILPPLVRAGTAIGTIA NEYASELGLSINAKVIAGGGDTQLAVKSTGAGLEDIVIVSGTTTPITKITEDHGDTKH KAWLNCHTDQGHWLVETNPGITGLNYQKLKQIFYPNETYEVMEEEISALAKEDHACVA ALGSYLSAEKNALTRGGFLFDAPLSAHLKRAHFVRAALEEIAFSIKWNFDILTEVTPF ERDYVWVCGGGFQSKALTQYIADLLQKKVYVQEGYHQASVVGAAVICNETFQLTEEMS ANVRVIEPKDCQIELALYEEWKQTQRFFSGSESKVLI*" /label="yoaC CDS" gene complement(1773774..1775237) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /label="yoaC gene" CDS complement(1775255..1776289) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10094622, 11390694, 12193636, 17012385, 18039762, 21749987, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-hydroxyacid dehydrogenase" /protein_id="NP_389738.1" /db_xref="EnsemblGenomes-Gn:BSU18560" /db_xref="EnsemblGenomes-Tr:CAB13749" /db_xref="GOA:O34815" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13475" /db_xref="UniProtKB/Swiss-Prot:O34815" /translation="MKNTMKRMFCSMTVLVTAPYNEEGRKELENLFGSVAYQSWKEQG RAYREDELIQLLKATNATGLITELDQVTDSVFASVPELSFVGVCRGMPSNVDVAAASK RGIPVFYTPGRNAQAVAEMFIGNVISFLRHTSASNQWLKDGEWDSDYLQAYVKFKGNE LTGKTVGMIGFGAVGQRIAKLLTAFDCKIKYYDPYIQDDHPLYEKASLKTVFSDSDIV SVHLPRTEETLGLIDRQYFDLMKESAIFVNTSRAVVVNREDLLFVLKEHKISGAILDV FYHEPPEESDYELISLPNVLATPHLAGATFEVEDHHVTILNKALKKWKGEKTLNIQTM YNKDALKTGG*" /label="yoaD CDS" gene complement(1775255..1776289) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /label="yoaD gene" S_feature complement(1776301..1776372) /Source="Nicolas_S_feature" /locus_tag="new_2025088_2025159_c" /HighExp="MG t5, MG 5, MG 10, BMM, GM 25, MG 15, Heat, GM 15, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S689" downshifts complement(1776344) /Source="Nicolas_upshifts" /id="D1017" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="7.78218" /MaxDrop="4.81701" /score="26.3160061" /energy="-11.4" /TU="U1504" /idTUdmin="U1507" /TUdmin=2727 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1776373..1776464) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /product="AdoMet riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswF RNA" gene complement(1776373..1776464) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /label="mswF gene" promotor_-10 complement(1776492..1776511) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1776504) /Source="Nicolas_upshifts" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1776526..1776533) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1776546..1776553 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1776567..1776586 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1776571 /Source="Nicolas_upshifts" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="upshifts" CDS 1776613..1778655 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170332, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin cofactor oxido-reductase" /protein_id="NP_389739.2" /db_xref="EnsemblGenomes-Gn:BSU18570" /db_xref="EnsemblGenomes-Tr:CAB13750" /db_xref="GOA:C0SP82" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG13476" /db_xref="UniProtKB/Swiss-Prot:C0SP82" /translation="MRSFATQQNGIFKSVCSLDCPDQCGLLIHKKDGKIVKVQGDPDH PVTAGNICNKVRNMTERIYDEKRLTTPLKRTGAKGQAIFEPISWKEAIDTITSRWKQL IDEEGAESILPYSFYGNMGKLTAEGMDRRFFYRMGSSQLERTICSKAGSEGYKYTMGI SAGIDPEETVHTKLFIFWGINAVSTNMHQITIAQKARKKGAKIVVIDVHKNQTGRLAD WFIPIKPGTDSALALGIMHILFKENLHDEAFLSEYTVGYEELREHVKQYDPEKVSTIT GVSTEDIYRLAKMYGETSPSFIRIGNGPQHHDNGGMIVRTIACLPAITGQWLHTGGGA IKHNSGILEYNTNALQRPDLLKGRTPRSFNMNQLGRVLLETDPPIRSLFIYGTNPAVV APEANKVRQGLLREDLFTVVHDLFLTETAAYADIVLPATSAFENTDFYTSYWHHYIQL QQPVIERYGESKSNTEVFRLLAEAMGFTDQELKDSDEVLIRQALDHPDNPHLAEIDYD SLTKHSFMKAKREKPLFPGELPTPSGKIELYSEKMKQDGFPALPTYTPLVTDNEHPFM YVPGPNHNFLNSTFSNNEKHIKLEKTPKLFINTKDAEKHGIVDGAPVRIWNSRGECEL TAAVGEQVLPGVVVSQGLWADEQGKKQLVNALTPDRLSDMGGGATFFSGRVQIEKV*" /label="yoaE CDS" gene 1776613..1778655 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /label="yoaE gene" promotor_-35 1778663..1778672 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1778685..1778700 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1778688 /Source="Nicolas_upshifts" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1778722..1779015 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389740.1" /db_xref="EnsemblGenomes-Gn:BSU18580" /db_xref="EnsemblGenomes-Tr:CAB13751" /db_xref="SubtiList:BG13477" /db_xref="UniProtKB/Swiss-Prot:O31829" /translation="MDVFLGIGIALAGYFIGEGLKQRNQTKGNEQNDIFLIKERDIYF YIGLFLGITTTEAKQLAGDMADLPYIEINGKKYVQKHMLKDWTFTLVEKHQGE*" /label="yoaF CDS" gene 1778722..1779015 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /label="yoaF gene" downshifts 1778995 /Source="Nicolas_upshifts" /id="D1018" /incds=0 /nref=97 /ntot=243 /MaxReadThrough="3.40762" /MaxDrop="4.1662" /score="-6.27063114" /energy="-3.9" /TU="U1506" /idTUdmin="U1505" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1779040..1779387) /Source="Nicolas_S_feature" /locus_tag="new_2027827_2028174_c" /HighExp="T0.30H, S0, T1.0H, aero, Etha, S8, SMMPr, T-0.40H, ferm, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S690" downshifts complement(1779071) /Source="Nicolas_upshifts" /id="D1019" /incds=0 /nref=43 /ntot=202 /MaxReadThrough="2.3171" /MaxDrop="4.25059" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1779388..1779792) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 15849754, 16850406, 20011599, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage-related membrane protein" /protein_id="NP_389741.1" /db_xref="EnsemblGenomes-Gn:BSU18590" /db_xref="EnsemblGenomes-Tr:CAB13752" /db_xref="GOA:O31830" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG13478" /db_xref="UniProtKB/Swiss-Prot:O31830" /translation="MKKIASYYLMTLGLSSLTFGLLLGFYSFVMYGDMIIALFTAAIA LLYGFVVYGLFAVPLQMKLQKKARTFNVMYLLIYSVVAFIAAFLFFVINEPASIAWTL QSYFYYMLSIAAAVIYWLWDSLILYKRTASGV*" /label="yoaG CDS" gene complement(1779388..1779792) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /label="yoaG gene" S_feature complement(1779793..1779888) /Source="Nicolas_S_feature" /locus_tag="new_2028580_2028675_c" /HighExp="T0.30H, T1.0H, T0.0H, T-0.40H, S0, T-1.10H, T-1.40H, SMMPr, Salt, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S691" promotor_-10 complement(1779878..1779893) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1779878..1779997) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513962.1" /translation="MHFFHSRFGQSGEAFSASVLSNKRTSFLKPFISALRIAR*" /label="hypothetical protein CDS" gene complement(1779878..1779997) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /label="gene" upshifts complement(1779888) /Source="Nicolas_upshifts" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1779906..1779915) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1779993..1779999 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1780013..1780024 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1780024..1780232 /Source="Nicolas_S_feature" /locus_tag="new_2028811_2029019" /HighExp="S5, S8, S7, S6, S4, ferm, BT, nit, T5.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99998799999999999" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S692" upshifts 1780024 /Source="Nicolas_upshifts" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1780067..1780189 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513963.1" /db_xref="EnsemblGenomes-Gn:BSU18596" /db_xref="EnsemblGenomes-Tr:CCQ48597" /db_xref="UniProtKB/TrEMBL:L8E9J0" /translation="MSKKGIQNSSIEQIRNDHETETAFKADDPKKHGSDPKRTK*" /label="conserved hypothetical protein CDS" gene 1780067..1780189 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /label="gene" CDS 1780233..1780526 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="YP_054581.1" /db_xref="EnsemblGenomes-Gn:BSU18600" /db_xref="EnsemblGenomes-Tr:CAE01456" /db_xref="InterPro:IPR025100" /db_xref="SubtiList:BG14189" /db_xref="UniProtKB/Swiss-Prot:Q7WY68" /translation="MTQKNGADRPDDYKRFSSLDKEYDFQQSIRSNTETESVNTETQT HNKENKNDTTDVAGKYFEPSDYKGSTQLEKGLAETHEQVSDDYFEGTIDQNLD*" /label="yozQ CDS" gene 1780233..1780526 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /label="yozQ gene" S_feature 1780527..1780620 /Source="Nicolas_S_feature" /locus_tag="new_2029314_2029407" /HighExp="S5, S8, S6, S7, S4, BT, ferm, nit, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S693" downshifts 1780577 /Source="Nicolas_upshifts" /id="D1020" /incds=0 /nref=14 /ntot=74 /MaxReadThrough="3.32407" /MaxDrop="3.87581" /score="-6.27063114" /energy="-3.9" /TU="U1508" /idTUdmin="U1506" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1780642..1782327) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting chemotaxis protein" /protein_id="NP_389742.2" /db_xref="EnsemblGenomes-Gn:BSU18610" /db_xref="EnsemblGenomes-Tr:CAB13753" /db_xref="GOA:C0SP89" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR007891" /db_xref="SubtiList:BG13479" /db_xref="UniProtKB/Swiss-Prot:C0SP89" /translation="MKVKTKLLGIISILVVSIIGIGGSSVFMISSTVKKNEELKDKME FQKEIKHIQYELTGLSNDERGFLITRDKEYDEGMKGKADDVLKSLDRVNDLIDEEKYQ SNIEDIKTSFTQYRALNQQVVTAYSSNPKKAETIHFGEERTIRKEGVAPAVNKLSDRL DQEVEDLKDEIQGNGKMSQSLIIIVTGISVILGIVLSIMLLKSIMVPLRSINKQLEEI AHGEADLTKKVIVKNKDEFGQLAQSFNSFTHSLTQIVKQISSSSEQVAASSEELSASA EESKSTSEHISRAMQMAADSNVKQSSMTEKSAESITELLDSISSVASNTGNIADLSSS MRDKAEIGSKSVNKMLDQMKFIDKSVDSAGNGLQTLVASTAEISDISSLITTISEQTN LLALNAAIEAARAGEQGKGFAVVAEEVRKLADETNKSANHIQSVVATIQNESIETVNN IKVVQENVSSGIVLSQETTGNFNEILNLVEQVTSQIQEVAAATQQLTSGVEVIQHTVH TLAAGTKETSANTEAVANSSQEQLHSMGEISYAAESLSQLAEELQTVINRFKY*" /label="yoaH CDS" gene complement(1780642..1782327) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /label="yoaH gene" downshifts complement(1780654) /Source="Nicolas_upshifts" /id="D1021" /incds=0 /nref=68 /ntot=193 /MaxReadThrough="2.22411" /MaxDrop="4.20676" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1509" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(1782328..1782415) /Source="Nicolas_S_feature" /locus_tag="new_2031115_2031202_c" /HighExp="Cold, C30, LBGstat, GM 90, GM 15, GM 45, GM 25, GM 60, GM 10, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115923" /TUshortSig="SigD" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S694" promotor_-10 complement(1782407..1782425) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1782415) /Source="Nicolas_upshifts" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1782439..1782446) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1782584..1782593 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1782603 /Source="Nicolas_upshifts" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1782606..1782625 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1782652..1784103 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /EC_number="1.14.14.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 4-hydroxyphenylacetate-3-hydroxylase" /protein_id="NP_389743.2" /db_xref="EnsemblGenomes-Gn:BSU18620" /db_xref="EnsemblGenomes-Tr:CAB13754" /db_xref="GOA:C0SPC0" /db_xref="InterPro:IPR004925" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR012687" /db_xref="InterPro:IPR024674" /db_xref="InterPro:IPR024719" /db_xref="InterPro:IPR036250" /db_xref="SubtiList:BG13480" /db_xref="UniProtKB/Swiss-Prot:C0SPC0" /translation="MGIINGKEFIDRLNKLENEIWYDGEKIKGNISEHPAFKGIIKTK SSLYELQTKDELIHEMTYCLPGDHNRIGLSYLQPKTKNDLKKRRTMIEHWARHTHGMM GRSPDYMNTVMMSFASSAELLKDKENCFPEHILDMYEQAAKHDLSFTHTFITPQVNRS QSYFGLSEKPISAKVIDRTEKGLMIHGARLLATQGGLTDEILVFSAPKFFFETDEAYA FSIPSNTKGVKFITRESFVLSDSSFNHPLSSRYEEMDSIVVFDHVLVPWNRVFFYDNV EAAKDFMTKSSFHAFTFHQVVIRQMIKIEFLLGVAQLLVDTINVSEYQHIQEKLSEII VGLETIKALIDKSENDAQLDEFGYMRPCLIPLQVISTIIPKLYPRFTEIIQLIGASGM VTLPTENAFDSEIREDLDQYLQATNTNAEERVKIFRLAWDLTMSSFGTRQTHYERYFF GDPIRISSRLYTSYPKQEQLNMIKTFLHADTEH*" /label="yoaI CDS" gene 1782652..1784103 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /label="yoaI gene" downshifts 1784079 /Source="Nicolas_upshifts" /id="D1022" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="2.84304" /MaxDrop="2.93575" /score="2.7297367" /energy="-12" /TU="U1510" /idTUdmin="U1510" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1784140..1784838) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 18971341, 26751268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 18971341, 26751268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular endoglucanase precursor (expansin)" /protein_id="NP_389744.1" /db_xref="EnsemblGenomes-Gn:BSU18630" /db_xref="EnsemblGenomes-Tr:CAB13755" /db_xref="GOA:O34918" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036749" /db_xref="InterPro:IPR036908" /db_xref="PDB:2BH0" /db_xref="PDB:3D30" /db_xref="PDB:4FER" /db_xref="PDB:4FFT" /db_xref="PDB:4FG2" /db_xref="PDB:4FG4" /db_xref="SubtiList:BG13481" /db_xref="UniProtKB/Swiss-Prot:O34918" /translation="MKKIMSAFVGMVLLTIFCFSPQASAAYDDLHEGYATYTGSGYSG GAFLLDPIPSDMEITAINPADLNYGGVKAALAGSYLEVEGPKGKTTVYVTDLYPEGAR GALDLSPNAFRKIGNMKDGKINIKWRVVKAPITGNFTYRIKEGSSRWWAAIQVRNHKY PVMKMEYEKDGKWINMEKMDYNHFVSTNLGTGSLKVRMTDIRGKVVKDTIPKLPESGT SKAYTVPGHVQFPE*" /label="exlX CDS" gene complement(1784140..1784838) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /label="exlX gene" downshifts complement(1784155) /Source="Nicolas_upshifts" /id="D1023" /incds=0 /nref=6 /ntot=95 /MaxReadThrough="0.66874" /MaxDrop="3.60414" /score="1.1918692" /energy="-7.7" /TU="NA" /idTUdmin="U1511" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1784873..1784892) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1784892) /Source="Nicolas_upshifts" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1784894..1785107) /Source="Nicolas_S_feature" /locus_tag="new_2033681_2033894_c" /HighExp="G135, H2O2, G150, G180, LBGstat, dia15, LBGtran, Paraq, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S695" promotor_-35 complement(1784906..1784913) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1785108..1785785) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_389745.1" /db_xref="EnsemblGenomes-Gn:BSU18640" /db_xref="EnsemblGenomes-Tr:CAB13756" /db_xref="GOA:O34343" /db_xref="InterPro:IPR010699" /db_xref="SubtiList:BG13482" /db_xref="UniProtKB/Swiss-Prot:O34343" /translation="MTAAAYRNTLLSLLCLTAGIVDVIGYLSLGHVFTANMTGNIVLL GLAIGKSIQVTVFNSLTALIGFICGVIIATLMVGKAENTLWPSAVTKALALEAFILFV FACLSFYRAFVPVHILIILMSISMGIQTTAAKKLGIAGISSTVLTGTLASLLEDISGR LFFKKQKKTFLRDTVLRALAIILYCVGAIIVALAEPDFYHFIIWVPIVLIFGIMMTAK LKLSGEK*" /label="yoaK CDS" gene complement(1785108..1785785) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /label="yoaK gene" S_feature complement(1785786..1788275) /Source="Nicolas_S_feature" /locus_tag="new_2034573_2037062_c" /HighExp="LBGstat, G135, H2O2, G180, LBGtran, G150, dia15, Paraq, S0, Diami" /AntisenseName="pelB" /AntisenseCor="0.19898265589133701" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S696" CDS 1785958..1786995 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /EC_number="4.2.2.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1731776, 2018526, 2185758, 7764549, 22695924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-pectin lyase" /protein_id="NP_389746.1" /db_xref="EnsemblGenomes-Gn:BSU18650" /db_xref="EnsemblGenomes-Tr:CAB13757" /db_xref="GOA:O34819" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12643" /db_xref="UniProtKB/Swiss-Prot:O34819" /translation="MKRLCLWFTVFSLFLVLLPGKALGAVDFPNTSTNGLLGFAGNAK NEKGISKTGTTGGKNGQIVYIQSVNDLKTHLGGSTPKILVLQNDLSASAKTTVTIGSN KTLVGSYAKKTLKNIYLTTSSAFGNVIFQNLTFEHSPQINGNNDIQLYLDSGMNYWID HVTFSGHSYNASGSDLDKLVYIGKSADYITISNSKFANHKYGLILGYPDDSQHQYDGY PHMTIANNYFENLYVRGPGLMRYGYFHVKNNYSNNFNQAITIATKAKIYSEYNYFGKG SEKGGILDDKGTGYFKDIGSYPSLNKQTSPLTSWNPGSNYSYRVQTPEYTKEFVTKYA GSQSTTLVFGY*" /label="pelB CDS" gene 1785958..1786995 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /label="pelB gene" promotor_-35 1787192..1787198 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1787213..1787224 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1787225 /Source="Nicolas_upshifts" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="upshifts" CDS 1787252..1787935 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23945014, 26070154; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative SOS response associated protein; defective prophage 6" /protein_id="NP_389747.1" /db_xref="EnsemblGenomes-Gn:BSU18660" /db_xref="EnsemblGenomes-Tr:CAB13758" /db_xref="GOA:O34906" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13483" /db_xref="UniProtKB/Swiss-Prot:O34906" /translation="MCGRFTLYSAFDDIIDQFDIDQFFPKGEYQPSYNVAPSQNILAI INDGSNNRLGKLRWGLIPPWAKDEKIGYKMINARAETITEKPAFRRPLVSKRCIIPAD SFYEWKRLDSKTKIPMRIKLKSSALFAFAGLYEKWSTHQGYPLYTCTIITTEPNEFMK DIHDRMPVILAHDHEKEWLNPKNTSPDYLQSLLLPYDADDMEAYQVSSLVNSPKNNSA ELLDAENHM*" /label="yoaM CDS" gene 1787252..1787935 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /label="yoaM gene" CDS complement(1788276..1788581) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative permease, phage-related; defective prophage 6" /protein_id="YP_003097734.1" /db_xref="EnsemblGenomes-Gn:BSU18669" /db_xref="EnsemblGenomes-Tr:CAX52628" /db_xref="GOA:C0H420" /db_xref="UniProtKB/Swiss-Prot:C0H420" /translation="MKALIFLSSLTAIGSSILGRWLGMLDDSYAVGDAWFIGVLAGLI SLLILIDSQTMTKNYIVSLSTILGILGVGFIYFPAAFINILLSITLDKQKKEDLHVR* " /label="yozS CDS" gene complement(1788276..1788581) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /label="yozS gene" S_feature complement(1788582..1788683) /Source="Nicolas_S_feature" /locus_tag="new_2037369_2037470_c" /HighExp="HiTm, LBGstat, LBGtran, T1.30H, T1.0H, T0.30H, M9-stat, Lbstat, M0t90, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S697" promotor_-10 complement(1788662..1788681) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1788683) /Source="Nicolas_upshifts" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1788696..1788703) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1788711..1788813) /Source="Nicolas_S_feature" /locus_tag="new_2037498_2037600_c" /HighExp="S8, S6, S7, S5, BT, G/S, Pyr, B36, nit, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S698" downshifts complement(1788753) /Source="Nicolas_upshifts" /id="D1024" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="1.67639" /MaxDrop="3.95763" /score="-5.39979801" /energy="-8.3" /TU="NA" /idTUdmin="U1514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1788814..1789992) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11546787, 14697267, 14973022, 15628860, 25526893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11546787, 14697267, 14973022, 15628860, 25526893; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase (Mn2+-dependent); spore constituent" /protein_id="NP_389748.1" /db_xref="EnsemblGenomes-Gn:BSU18670" /db_xref="EnsemblGenomes-Tr:CAB13759" /db_xref="GOA:O34767" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="SubtiList:BG13484" /db_xref="UniProtKB/Swiss-Prot:O34767" /translation="MLLEQQPINHEDRNVPQPIRSDGAGAIDTGPRNIIRDIQNPNIF VPPVTDEGMIPNLRFSFSDAPMKLDHGGWSREITVRQLPISTAIAGVNMSLTAGGVRE LHWHKQAEWAYMLLGRARITAVDQDGRNFIADVGPGDLWYFPAGIPHSIQGLEHCEFL LVFDDGNFSEFSTLTISDWLAHTPKDVLSANFGVPENAFNSLPSEQVYIYQGNVPGSV ASEDIQSPYGKVPMTFKHELLNQPPIQMPGGSVRIVDSSNFPISKTIAAALVQIEPGA MRELHWHPNSDEWQYYLTGQGRMTVFIGNGTARTFDYRAGDVGYVPSNAGHYIQNTGT ETLWFLEMFKSNRYADVSLNQWMALTPKELVQSNLNAGSVMLDSLRKKKVPVVKYPGT *" /label="oxdD CDS" gene complement(1788814..1789992) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /label="oxdD gene" promotor_-10 complement(1790018..1790037) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1790037) /Source="Nicolas_upshifts" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1790051..1790060) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1790115..1790603) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389749.1" /db_xref="EnsemblGenomes-Gn:BSU18680" /db_xref="EnsemblGenomes-Tr:CAB13760" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG13485" /db_xref="UniProtKB/Swiss-Prot:O34985" /translation="MRKKNNIKKWLLIIAGFLIICIITLFVMVSGNKVKYEGSGKSGL WMSNLEKSDKTSIGPNYFLNLYWQGSKKEEKWTVVERITLYVDGEKYQDDNVDEYDLS EYTGDEMPGGGRMEDHISTFDYMPEDEVIGHDVLVKVEWRTGQKKQTEAIKLHKKPWY KK*" /label="yoaO CDS" gene complement(1790115..1790603) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /label="yoaO gene" downshifts complement(1790140) /Source="Nicolas_upshifts" /id="D1025" /incds=0 /nref=32 /ntot=201 /MaxReadThrough="0.50319" /MaxDrop="3.84714" /score="18.561323" /energy="-9.2" /TU="NA" /idTUdmin="U1514" /TUdmin="-1387" /isTUend="FALSE" /label="downshifts" CDS complement(1790628..1790783) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513964.1" /translation="MKQKMHLRAVIRFNLVFRKHFNLSQKFRQSSVRSLALSYFLFGN ILIVFSY*" /label="hypothetical protein CDS" gene complement(1790628..1790783) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /label="gene" CDS complement(1790823..1791578) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389750.1" /db_xref="EnsemblGenomes-Gn:BSU18690" /db_xref="EnsemblGenomes-Tr:CAB13761" /db_xref="GOA:O34983" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR025685" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13486" /db_xref="UniProtKB/Swiss-Prot:O34983" /translation="MCYIEITKDNIEDNHICCALSTKQYEHAVNEKKRWLKARMDEGL VFYRLHERAKVFIEYLPANEAWVPINAPNFMYINCLWVSGRYKNNGHAKRLLDKCIAD AKACGMDGIIHIAGKKKLPYLSDKHFFEHMGFTLQDEAAPYFQLMALTWNGLADSPAF KSQVKSDSINEKGITIYYTAQCPFAVGMINDLRELTEKKGVQFQSIQLSSKEEAQKSP AIWTTFSVFFDGRFVTHEIMSINKFEKLLNTLA*" /label="yoaP CDS" gene complement(1790823..1791578) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /label="yoaP gene" promotor_-35 1791831..1791836 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1791852..1791870 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1791867 /Source="Nicolas_upshifts" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="upshifts" CDS 1791886..1792242 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389751.1" /db_xref="EnsemblGenomes-Gn:BSU18700" /db_xref="EnsemblGenomes-Tr:CAB13762" /db_xref="SubtiList:BG13487" /db_xref="UniProtKB/Swiss-Prot:O31831" /translation="MVEKCYSCLICGYKGLIQNPLYKGEYQKTFDICPCCGFEFGYSE DHDVRLGFIVTPDHLIEAAFQLYRKQWLESGMVIAHPEDIPEELKNGNCLKFEVLLKQ LKKLNLDIENFEISGF*" /label="yoaQ CDS" gene 1791886..1792242 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /label="yoaQ gene" CDS complement(1792201..1792440) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (putative phage origin); putative defective prophage 6" /protein_id="YP_003097735.1" /db_xref="EnsemblGenomes-Gn:BSU18709" /db_xref="EnsemblGenomes-Tr:CAX52629" /db_xref="UniProtKB/Swiss-Prot:C0H421" /translation="MTVINDYREEPEEAFWILYPMGVKCLSMITKSLLNTNRDFVTDC AFQLNILLIMTVKPKQVQPVSSLKTANFKIFYVKI*" /label="yozT CDS" gene complement(1792201..1792440) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /label="yozT gene" S_feature 1792243..1792679 /Source="Nicolas_S_feature" /locus_tag="new_2041030_2041466" /HighExp="S8, S7, S4, S5, S6, S3, T5.0H, LoTm, BT, T4.0H" /AntisenseName="yozT" /AntisenseCor="0.93420248567111996" /AntisenseRegPval="-120.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S699" S_feature complement(1792441..1792542) /Source="Nicolas_S_feature" /locus_tag="new_2041228_2041329_c" /HighExp="S8, S7, S6, S5, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S700" CDS complement(1792543..1793040) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389752.2" /db_xref="EnsemblGenomes-Gn:BSU18710" /db_xref="EnsemblGenomes-Tr:CAB13763" /db_xref="SubtiList:BG13753" /db_xref="UniProtKB/Swiss-Prot:O31832" /translation="MKRVLFSVIVFTAVGFTFCQSKAHALTFTVLPITQKTDQWSVKV SEAKNVKEFTRPHKGEYQVYSLEVKNIGEKAATVDVQLYRNDPNSITRFSLFGCPDEN CVKPKEDSKMLAESLNDGSPLKFNHFMLADKASELEVVIIWTQKGQEGRNLKQTFKFT EDGVN*" /label="yozF CDS" gene complement(1792543..1793040) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /label="yozF gene" S_feature complement(1793041..1793140) /Source="Nicolas_S_feature" /locus_tag="new_2041828_2041927_c" /HighExp="S8, S7, S5, S6, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S701" CDS complement(1793141..1794052) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8631706; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor for cell wall maintenance or synthesis" /protein_id="NP_389753.1" /db_xref="EnsemblGenomes-Gn:BSU18720" /db_xref="EnsemblGenomes-Tr:CAB13764" /db_xref="InterPro:IPR007391" /db_xref="SubtiList:BG13488" /db_xref="UniProtKB/Swiss-Prot:O34611" /translation="MIQILITGLFLLAQPSEPQDSLTVTQQGRTIATVNREDFTMPLP GTPMVDYEKYSKFIKQLDQKVYREPINAVLNDHGSIVPGRVGYKLYQQAFMEKFYAYF YGQGPSKIEVPEMNIYPKVDSELLAHISTQQLGQYVTYFNSSNKSRSHNISLSAKAID NHVVFPNETFSFNQVVGMRTRNKGYKSAPIIVKGELSEGVGGGICQVSSTLFNAVDRA GLQIVQRYSHTRSVPYVPPGRDATVSWGGPDFRFQNQYNQPILIRAKRYGGSMIITLY SSDVINSRLRKIPKAPSRIPKEINAEQ*" /label="yoaR CDS" gene complement(1793141..1794052) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /label="yoaR gene" promotor_-10 complement(1794074..1794085) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1794076) /Source="Nicolas_upshifts" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1794100..1794106) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1794336..1794343 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1794352 /Source="Nicolas_upshifts" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1794358..1794377 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1794399..1794881 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19493340; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin / antitoxin system" /protein_id="NP_389754.1" /db_xref="EnsemblGenomes-Gn:BSU18730" /db_xref="EnsemblGenomes-Tr:CAB13765" /db_xref="GOA:O31833" /db_xref="InterPro:IPR021354" /db_xref="SubtiList:BG13489" /db_xref="UniProtKB/Swiss-Prot:O31833" /translation="MNRMSTIFLKIALVLIGIPILALCIFLVPKVANYSAELFPNIAY IKYLVFIYLYVTAIPFYFALYQAFKLLSYIDKNKAFSGLSVRALKNIKYCAVTISIFY AAGMPVFYLMAEIDDAPGIIVIGLVIIFASMVIAVFAAVLQKLLKEAIDIKSENDLTV *" /label="yoaS CDS" gene 1794399..1794881 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /label="yoaS gene" CDS 1794891..1795145 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19493340; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin of a toxin / antitoxin system; putative transcriptional regulator" /protein_id="NP_389755.1" /db_xref="EnsemblGenomes-Gn:BSU18740" /db_xref="EnsemblGenomes-Tr:CAB13766" /db_xref="GOA:O31834" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG13754" /db_xref="UniProtKB/Swiss-Prot:O31834" /translation="MAIIINIDVMLAKRKMSVTELSERVGITMANLSILKNGKAKAIR LSTLEAICKALECQPGDILEYRSDEDTGFVKKKYEGSTEK*" /label="yozG CDS" gene 1794891..1795145 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /label="yozG gene" S_feature 1795146..1795250 /Source="Nicolas_S_feature" /locus_tag="new_2043933_2044037" /HighExp="LoTm, B60, Sw, G135, G180, B36, LBGstat, Cold, LBGtran, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S702" CDS 1795251..1796045 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389756.1" /db_xref="EnsemblGenomes-Gn:BSU18750" /db_xref="EnsemblGenomes-Tr:CAB13767" /db_xref="GOA:O34535" /db_xref="InterPro:IPR008535" /db_xref="SubtiList:BG13490" /db_xref="UniProtKB/Swiss-Prot:O34535" /translation="MRAIKQIVHFGWEQALSCLFPAVIFASLAITQIIPLPFLPRYDW LLIICVLMQLWMVRSGLETRDELKVITLFHLIGLALELFKVHMGSWSYPEEGYSKIFG VPLYSGFMYASVASYLCQAWRRLKVELVKWPSFFAVVPLAAAIYLNFFTHHFSIDIRW WLSGLVIIVFWQTWVTYEVNGARYRMPLALSFILIGFFIWIAENIATFFGAWKYPNQI DTWSLVHLGKVSSWLLLVIVSFLIVASLKQVKEQSPTKAEMDESFS*" /label="yoaT CDS" gene 1795251..1796045 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /label="yoaT gene" S_feature 1796046..1797056 /Source="Nicolas_S_feature" /locus_tag="new_2044833_2045843" /HighExp="LoTm, Cold, Sw, H2O2, B60, GM 10, S8, dia15, T2.30H, MG 60" /AntisenseName="yoaU" /AntisenseCor="-2.6976304882719598E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S703" CDS complement(1796169..1797041) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_389757.1" /db_xref="EnsemblGenomes-Gn:BSU18760" /db_xref="EnsemblGenomes-Tr:CAB13768" /db_xref="GOA:O34701" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13491" /db_xref="UniProtKB/Swiss-Prot:O34701" /translation="MVMNMNHLHIFVKVGEKLNITEAAKELFISQPAVSKAIKNLESS LQLKLLIRDKHHGLMLTDIGKEILLLARQMKGIESKIYQVANRENKLLNGKVKIGSFP AVSTNIMPQAIAAFRSNYPLIRIELIEGTSDQIKGWVEDRTVDIGIAASPFEPFENQL LCNDYMVAVIPPQRDELKLEKHVDLETYQDDLIFCKGGHEIAMSNAFSQYNIELKENL TVQNAETLINMVKNNLGIGIISNFTLSSVPHQLIKKDIFPRVTRDIGVIAHSFEEITP AAHEFVKVLKAVVI*" /label="yoaU CDS" gene complement(1796169..1797041) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /label="yoaU gene" CDS 1797142..1798020 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10844694, 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative modified amino acid or TCA compound efflux permease" /protein_id="NP_389758.1" /db_xref="EnsemblGenomes-Gn:BSU18770" /db_xref="EnsemblGenomes-Tr:CAB13769" /db_xref="GOA:O34416" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG13492" /db_xref="UniProtKB/Swiss-Prot:O34416" /translation="MVKVMLGIISVTLIWGYTWVAMKVGIHDIPPLLFSGLRLFIGAV PLFLILFIQRKKLSIQKEHLKSYIIMSLLMGLGYMGILTYGMQFVDSGKTSVLVYTMP IFVTVISHFSLNEKMNVYKTMGLVCGLFGLLFIFGKEMLNIDQSALFGELCVLVAALS WGIANVFSKLQFKHIDIIHMNAWHLMMGAVMLLVFSFIFEAVPSAEWTYQAVWSLLFN GLLSTGFTFVVWFWVLNQIQASKASMALMFVPVLALFFGWLQLHEQITINIILGALLI CCGIFMNTFTFSRRKV*" /label="yoaV CDS" gene 1797142..1798020 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /label="yoaV gene" S_feature complement(1798133..1798192) /Source="Nicolas_S_feature" /locus_tag="new_2046920_2046979_c" /HighExp="BC, T4.0H, M9-stat, S5, T5.0H, S4, S3, T3.0H, T3.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.167154" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S704" downshifts complement(1798168) /Source="Nicolas_upshifts" /id="D1026" /incds=0 /nref=55 /ntot=175 /MaxReadThrough="1.78313" /MaxDrop="5.17096" /score="15.465237" /energy="-12.3" /TU="NA" /idTUdmin="U1518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1798193..1798624) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm forming exported protein" /protein_id="NP_389759.1" /db_xref="EnsemblGenomes-Gn:BSU18780" /db_xref="EnsemblGenomes-Tr:CAB13770" /db_xref="SubtiList:BG13493" /db_xref="UniProtKB/Swiss-Prot:O34541" /translation="MKKMLMLAFTFLLALTIHVGEASAVIVKDEEKVSFTMTENEKWF MKSDDLNSNHWTSHFGYRFTIFDTEGCTINARIMRMTLSGYEITVSEKNFSGDHFDFS ATDRVETMPYKTHYLILTKDPDCGDVKVKGLYGFQFDQPEW*" /label="yoaW CDS" gene complement(1798193..1798624) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /label="yoaW gene" promotor_-10 complement(1798644..1798663) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1798652) /Source="Nicolas_upshifts" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1798654..1798887) /Source="Nicolas_S_feature" /locus_tag="new_2047441_2047674_c" /HighExp="S4, S3, S5, S7, S8, S6, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S705" promotor_-35 complement(1798677..1798683) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1798888..1798906) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1798888..1799520) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16181642; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor of the oxidative stress response" /protein_id="NP_389760.1" /db_xref="EnsemblGenomes-Gn:BSU18790" /db_xref="EnsemblGenomes-Tr:CAB13771" /db_xref="GOA:O34947" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13494" /db_xref="UniProtKB/Swiss-Prot:O34947" /translation="MQTRKVYLYVFHTMSDWEYGYLIAELNSGRYFKQDAASLKVVTV GVNKEMITTLGGLSIKPDISLDECTLGSQDLIILPGGNTWGEDIHQPILKKVGDALKL GTTIAAICGATLGLANEGYLNSRKHTSNDLDYMNMVCPNYKGETFYEKGPAVSDENLV TASGIAPLEFAVEVLKKLDVFAPDTLRSWYKLNKTQKPEYFFELMNTINR*" /label="yoaZ CDS" gene complement(1798888..1799520) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /label="yoaZ gene" upshifts complement(1798894) /Source="Nicolas_upshifts" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1798922..1798927) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1799658..1799665 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1799680..1799699 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1799684 /Source="Nicolas_upshifts" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="upshifts" CDS 1799746..1800666 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /EC_number="3.5.2.6" /function="16.5: Explore" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7789815, 15187182, 16944130, 22211522, 25112476, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-lactamase precursor (putative hydrolase)" /protein_id="NP_389761.1" /db_xref="EnsemblGenomes-Gn:BSU18800" /db_xref="EnsemblGenomes-Tr:CAB13772" /db_xref="GOA:P39824" /db_xref="InterPro:IPR000871" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023650" /db_xref="SubtiList:BG11016" /db_xref="UniProtKB/Swiss-Prot:P39824" /translation="MKLKTKASIKFGICVGLLCLSITGFTPFFNSTHAEAKSIEDTNM ASCITNKKFVQLEKKFDARLGVYAIDIGSNKTIAYRPNERFAYASTYKVLAAAAVLKK NSIEKLNEVIHYSKDDLVTYSPITEKHLDTGMSLKEISEAAIRYSDNTAGNILLQQLG GPKGFEKSLKQIGDHVTKAKRFETDLNSAIPGDIRDTSTAKALATDLKAFTLDNTLTT DKRMILTDWMRGNATGDELIRAGAPIGWEVGDKSGAGSYGTRNDIAIVWPPNRAPIVV AILSNRFTKDANYDNALIAEAAKVVLNDLK*" /label="penP CDS" gene 1799746..1800666 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /label="penP gene" promotor_-10 complement(1800177..1800196) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1800192) /Source="Nicolas_upshifts" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1800211..1800218) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1800667..1801324 /Source="Nicolas_S_feature" /locus_tag="new_2049454_2050111" /HighExp="HiOs, S8, GM 25, GM 15, GM-0.1, C30, S2, S1, BC, GM 45" /AntisenseName="yobA" /AntisenseCor="8.9918765131424994E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S706" CDS complement(1801163..1801525) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389762.1" /db_xref="EnsemblGenomes-Gn:BSU18810" /db_xref="EnsemblGenomes-Tr:CAB13773" /db_xref="InterPro:IPR021598" /db_xref="PDB:2JQO" /db_xref="PDB:4QY7" /db_xref="SubtiList:BG13495" /db_xref="UniProtKB/Swiss-Prot:O31835" /translation="MPKIGVSLIVLIMLIIFLAGCNKNEQNGDETKMQSLVGYVVLKD NERAILITDTKAPGKEDYNLSEGQLMNKFKNNIVIVGLSEIDNTDDLKRGEKIKVWFH TRKESNPPSATIQKYELL*" /label="yobA CDS" gene complement(1801163..1801525) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /label="yobA gene" CDS complement(1801586..1801798) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage protein" /db_xref="PSEUDO:CAX52630.1" /translation="MEVAIVNDSKDKYIYAGIQKEAAFNNIFESAKMSKRIISRATTC KYLRKNKKKVEELENEYAAVMNCKKK*" /label="yozU CDS" gene complement(1801586..1801798) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /pseudo /label="yozU gene" promotor_-35 1801837..1801844 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1801859..1801878 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1801862 /Source="Nicolas_upshifts" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="upshifts" CDS 1801902..1802165 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="NP_389763.1" /db_xref="EnsemblGenomes-Gn:BSU18820" /db_xref="EnsemblGenomes-Tr:CAB13774" /db_xref="SubtiList:BG13496" /db_xref="UniProtKB/Swiss-Prot:O31836" /translation="MKIRKILLSSALSFGMLISAVPALAAGTSSEVAVKNEEYDYDTI YRISPLPMDFQPTIEYNGYTYTLTRHYFDYSIGFYTAIYTKVV*" /label="yobB CDS" gene 1801902..1802165 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /label="yobB gene" downshifts 1802143 /Source="Nicolas_upshifts" /id="D1027" /incds=0 /nref=23 /ntot=100 /MaxReadThrough="0.60454" /MaxDrop="4.81085" /score="19.5390064" /energy="-8.7" /TU="NA" /idTUdmin="U1522" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1802542..1805142) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /EC_number="2.7.9.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PEP-dependent enzyme" /protein_id="NP_389764.1" /db_xref="EnsemblGenomes-Gn:BSU18830" /db_xref="EnsemblGenomes-Tr:CAB13775" /db_xref="GOA:O34309" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG12657" /db_xref="UniProtKB/Swiss-Prot:O34309" /translation="MSSLVLGLHEIEKTQLSLVGGKGLHLGELSKIQGIQVPEGFCVT TVGYQKAIEQNETLQVLLDQLTMLKVEDRDQIGNISRKIRQIIMEVDIPSDVVKAVAQ YLSQFGEEHAYAVRSSATAEDLPHASFAGQQDTYLNITGVDAILQHISKCWASLFTDR AVIYRMQNGFDHSQVYLSVIVQRMVFPQASGILFTADPITSNRKVLSIDAGFGLGEAL VSGLVSADCFKVQDGQIIDKRIATKKMAIYGRKEGGTETQQIDSDQQKAQTLTDEQIL QLARIGRQIEAHFGQPQDIEWCLARDTFYIVQSRPITTLFPIPEASDQENHVYISVGH QQMMTDPIKPLGLSFFLLTTVAPMRKAGGRLFVDVTHHLASPDSREVFLKGMGQHDQL LKDALMTIIKRRDFIKSIPNDKTAPNPSRGNADMPAQVENDPTIVSDLIESSQTSIEE LKQNIQTKSGSDLFRFILEDIQELKKILFNPKSSVLIRTAMNASLWINEKMNEWLGEK NAADTLSQSVPHNITSEMGLALLDVADVIRPYPEVIDYLQHVKDDNFLDELAKFDGGS KTRDAIYDYLSKYGMRCTGEIDITRTRWSEKPTTLVPMILNNIKNFEPNVGHRKFEQG RQEALKKEQELLDRLKQLPDGEQKAKETKRAIDIIRNFSGFREYPKYGMVNRYFVYKQ ALLKEAEQLIEAGVIHEKEDIYYLTFEELHEVVRTHKLDYQIISTRKDEYTLYEKLSP PRVITSDGEIVTGEYKRENLPAGAIVGLPVSSGVIEGRARVILNMEDADLEDGDILVT SFTDPSWTPLFVSIKGLVTEVGGLMTHGAVIAREYGLPAVVGVENAAKLIKDGQRIRV HGTEGYIEIF*" /label="yppS CDS" gene complement(1802542..1805142) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /label="yppS gene" S_feature complement(1805143..1805252) /Source="Nicolas_S_feature" /locus_tag="new_2053930_2054039_c" /HighExp="dia15, BC, S6, SMMPr, H2O2, S5, T-5.40H, S4, HPh, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S707" promotor_-35 1805168..1805175 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1805190..1805209 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1805198..1805825 /Source="Nicolas_S_feature" /locus_tag="new_2053985_2054612" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, S1, T2.30H, Heat, S2, T-5.40H, C30" /AntisenseName="xynA" /AntisenseCor="-0.30871986344497798" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S708" upshifts 1805198 /Source="Nicolas_upshifts" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1805242..1805261) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1805252) /Source="Nicolas_upshifts" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1805276..1805282) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1805298..1805757) /Source="Nicolas_S_feature" /locus_tag="new_2054085_2054544_c" /HighExp="S0, Lbstat, HiTm, dia0, ferm, Lbexp, T1.0H, M0t45, LBGtran, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S709" downshifts complement(1805340) /Source="Nicolas_upshifts" /id="D1028" /incds=0 /nref=87 /ntot=200 /MaxReadThrough="1.89557" /MaxDrop="5.26144" /score="1.97345986" /energy="-10.4" /TU="NA" /idTUdmin="U1525" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1805802) /Source="Nicolas_upshifts" /id="D1029" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="5.28207" /MaxDrop="3.16026" /score="1.97345986" /energy="-10.4" /TU="U1525" /idTUdmin="U1525" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(1805812..1806453) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /EC_number="3.2.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7704256, 8628241, 16517552, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704256, 8628241, 16517552, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-1,4-beta-xylanase" /protein_id="NP_389765.1" /db_xref="EnsemblGenomes-Gn:BSU18840" /db_xref="EnsemblGenomes-Tr:CAB13776" /db_xref="GOA:P18429" /db_xref="InterPro:IPR001137" /db_xref="InterPro:IPR013319" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018208" /db_xref="InterPro:IPR033119" /db_xref="InterPro:IPR033123" /db_xref="PDB:1AXK" /db_xref="PDB:1XXN" /db_xref="PDB:2B42" /db_xref="PDB:2B45" /db_xref="PDB:2B46" /db_xref="PDB:2DCY" /db_xref="PDB:2DCZ" /db_xref="PDB:2QZ3" /db_xref="PDB:2Z79" /db_xref="PDB:3EXU" /db_xref="PDB:3HD8" /db_xref="PDB:5K9Y" /db_xref="SubtiList:BG10808" /db_xref="UniProtKB/Swiss-Prot:P18429" /translation="MFKFKKNFLVGLSAALMSISLFSATASAASTDYWQNWTDGGGIV NAVNGSGGNYSVNWSNTGNFVVGKGWTTGSPFRTINYNAGVWAPNGNGYLTLYGWTRS PLIEYYVVDSWGTYRPTGTYKGTVKSDGGTYDIYTTTRYNAPSIDGDRTTFTQYWSVR QSKRPTGSNATITFSNHVNAWKSHGMNLGSNWAYQVMATEGYQSSGSSNVTVW*" /label="xynA CDS" gene complement(1805812..1806453) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /label="xynA gene" S_feature complement(1806454..1806571) /Source="Nicolas_S_feature" /locus_tag="new_2055241_2055358_c" /HighExp="S0, HiTm, T1.0H, Gly, Lbstat, SMMPr, Lbtran, LBGstat, SMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S710" promotor_-10 complement(1806548..1806567) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1806571) /Source="Nicolas_upshifts" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1806581..1806583) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1806659,1806666) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs05" N_region 1806660..1806665 /note="SacI site (GAGCTC)" /modified_by="User" /label="IIG_Bs05" misc_RNA <1806666..1806750 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" /product="small untranslated regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 19542274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 19542274; Product type n: RNA" /label="bsrF RNA" S_feature <1806666..1806743 /Source="Nicolas_S_feature" /locus_tag="new_2079086_2079196" /HighExp="LoTm, S7, HPh, LPhT, S8, BT, S6, G/S, S0, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.896, 1" /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S728" S_feature complement(<1806666..1806730) /Source="Nicolas_S_feature" /locus_tag="new_2078548_2079183_c" /HighExp="MG 150, S8, MG 120, S7, MG 90, GM-0.1, Glu, Fru, GM-0.2, GM 5" /AntisenseName="yobO" /AntisenseCor="0.134597835896198" /AntisenseRegPval="-1.6" /CDS_PredictionProba="0.40121099999999998" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S726" gene <1806666..1806750 /gene="bsrF" /old_locus_tag="BSU_misc_RNA_75" /locus_tag="PG10_pseudo_BSU_misc_RNA_75" /modified_by="User" /label="PG10_pseudo_BSU_misc_RNA_75" downshifts 1806728 /Source="Nicolas_upshifts" /id="D1044" /incds=0 /nref=65 /ntot=254 /MaxReadThrough="1.60135" /MaxDrop="9.06442" /score="30.7999406" /energy="-13.9" /TU="NA" /idTUdmin="U1545" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1806761..1807093) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /function="16.1: Circulate" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10658654, 10816431, 13129613, 15856219, 17372352, 28724440; Product type f : factor" /codon_start=1 /transl_table=11 /product="molecular chaperone for secreting proteins" /protein_id="NP_389785.1" /db_xref="EnsemblGenomes-Gn:BSU19040" /db_xref="EnsemblGenomes-Tr:CAB13796" /db_xref="GOA:P37584" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR008231" /db_xref="InterPro:IPR012340" /db_xref="PDB:2NZH" /db_xref="PDB:2NZO" /db_xref="SubtiList:BG10809" /db_xref="UniProtKB/Swiss-Prot:P37584" /translation="MAVIDDFEKLDIRTGTIVKAEEFPEARVPAIKLVIDFGTEIGIK QSSAQITKRYKPEGLINKQVIAVVNFPPRRIAGFKSEVLVLGGIPGQGDVVLLQPDQP VPNGTKIG*" /label="csaA CDS" gene complement(1806761..1807093) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /label="csaA gene" downshifts complement(1806775) /Source="Nicolas_upshifts" /id="D1045" /incds=0 /nref=28 /ntot=228 /MaxReadThrough="4.42209" /MaxDrop="5.706" /score="-8.98970984" /energy="-13.9" /TU="U1547" /idTUdmin="U1550" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1807158..1807883) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478, 27038276; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_389786.1" /db_xref="EnsemblGenomes-Gn:BSU19050" /db_xref="EnsemblGenomes-Tr:CAB13797" /db_xref="GOA:O34901" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG13508" /db_xref="UniProtKB/Swiss-Prot:O34901" /translation="MLMDSLQEIICEKRTYTRLYHSHKHAYSQFLFPLEGSIDLETEG RQVKLNPDHFLYIPPQCEHRFRSIGRNECLVLDVPLHAMKIDEYRAGSGIEAALDPFW SSIRYLLTEEAKAGTANSLHMLVQYIKEKLQSHSYASIAYIHSHLFERLTIKKLAEIE HYHPAYYSSWFKKQTGKSPQNYIADLRLEEAKRMLMERNETLTVVSEALGFQNLSSFT RWFTKSTGMPPRLYRNTLYSDKK*" /label="yobQ CDS" gene complement(1807158..1807883) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /label="yobQ gene" CDS complement(1807898..1808641) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389787.1" /db_xref="EnsemblGenomes-Gn:BSU19060" /db_xref="EnsemblGenomes-Tr:CAB13798" /db_xref="GOA:O34376" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13509" /db_xref="UniProtKB/Swiss-Prot:O34376" /translation="MDDIRKIERLAAASWPAYFQKSIGKWLLRANFGVTKRANSVWTS ADMPEGDFQLEAELFYQSLGLPVCFHISNASPKGLDDALADSRYEKVDECFQMTALCR SIMSRTNDNSRFTYKWEQEPSSVWIDEFIQLEGFSPERHKGYKHIFERMPPCKTFFKM YDKESLTALGTVSVIDGYGGLSNIVVAEEHRGKGAGTQVIRVLTEWAKNNGAERMFLQ VMKENLAAVSLYGKIGFSPISEHHYRIKR*" /label="yobR CDS" gene complement(1807898..1808641) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /label="yobR gene" promotor_-10 complement(1808669..1808688) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1808688) /Source="Nicolas_upshifts" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1808702..1808708) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1808719..1809294) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389788.1" /db_xref="EnsemblGenomes-Gn:BSU19070" /db_xref="EnsemblGenomes-Tr:CAB13799" /db_xref="GOA:O34892" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025996" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG13510" /db_xref="UniProtKB/Swiss-Prot:O34892" /translation="MSPRIGLTQKMIVDAAAEIADQEGVNGVSLAALSKKMNVRPPSL YNHINGLQAIRAELAVRGLTKLFDQMADSVTERKGDSAMLSLAHAYVDFAIENPGYYE AALLKVHDKRTEIVSDQIVCLVTKLLIENGYASEKTAIHATRGLRSLLHGFTVLIAKE AFEREEDILESLSFSIRTFLSGLLINNKNIM*" /label="yobS CDS" gene complement(1808719..1809294) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /label="yobS gene" CDS complement(1809300..1810001) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_389789.1" /db_xref="EnsemblGenomes-Gn:BSU19080" /db_xref="EnsemblGenomes-Tr:CAB13800" /db_xref="GOA:O34910" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13511" /db_xref="UniProtKB/Swiss-Prot:O34910" /translation="MRITQYQTVWQLTFFPALFPVNCYLVEEENEVTLIDAALPGSYK GIIQAVNQLGKPLQHILLTHAHGDHVGSLDTLAQTFPHAKVMISERDSFLLQGDTSLR QDEPQTPIKGGIPKHIQTKPHQLLTGGETIGSLLAIPTPGHTPGSMSFLDTRNGTLIA GDAFQLRGGIAVSGQIKWAFPFPAFATWNKEEAIKSAQLLADKAPSCLAVGHGKFLRS PSERMRQAIQKAKKG*" /label="yobT CDS" gene complement(1809300..1810001) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /label="yobT gene" promotor_-10 complement(1810031..1810050) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1810031) /Source="Nicolas_upshifts" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1810035..1810050) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1810065..1810072) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1810065..1810072) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1810075) /Source="Nicolas_upshifts" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1810078..1810560) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative effector of transcriptional regulator" /protein_id="NP_389790.1" /db_xref="EnsemblGenomes-Gn:BSU19090" /db_xref="EnsemblGenomes-Tr:CAB13801" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG13512" /db_xref="UniProtKB/Swiss-Prot:O34637" /translation="MGFSHITHLDLKRFAGLSQRTSNALEMTEERRIPALWDQLWKQD MSALLSQAEKDKSIIALYSNYEQETNGFYTFSVGTFQEYDDILPGPYENIDLPASAYA VFTSRIGPIEEIVLETWKEIWTWDKRHLRTFTGDFEMYDQNAAVPQRAQVNIYVAIKK *" /label="yobU CDS" gene complement(1810078..1810560) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /label="yobU gene" misc_feature complement(1810599..1810616) /Source="Nicolas_upshift_promotors" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1810603) /Source="Nicolas_upshifts" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1810614..1811555) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389791.1" /db_xref="EnsemblGenomes-Gn:BSU19100" /db_xref="EnsemblGenomes-Tr:CAB13802" /db_xref="GOA:O34920" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026881" /db_xref="InterPro:IPR028349" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13513" /db_xref="UniProtKB/Swiss-Prot:O34920" /translation="MKLERLLAMVVLLISKKQVQAAELAELFEVSVRTIYRDIETINR AGIPIVTSQGSGGGIGIMETYRLEREWLKEEELFAIASALQSVSSMYEPVSHSTAYQK IKHLIPEQSTQAFKHQTEKWFIDMTAWGHTEDQKTLREKISAAIDRLLTISFTYTSAS GETLLRETEPYTLVCKAGHWYLYAYCLVRNDFRFFKLNRMKDLAILHQTFIRKDIQLD TLPWDKSWYQKDRLTELVILVQPSARQRIGEWFGYDVLHCCEEDEICQAVISLPEDQW LIGFLLQFGKDIEVLQPLHIRDKVKETIHHMQKIYET*" /label="yobV CDS" gene complement(1810614..1811555) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /label="yobV gene" downshifts complement(1810647) /Source="Nicolas_upshifts" /id="D1046" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="0.95712" /MaxDrop="3.62763" /score="-3.71616684" /energy="-9" /TU="NA" /idTUdmin="U1548" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1811585..1811604) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1811593) /Source="Nicolas_upshifts" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1811618..1811622) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1811626..1811635 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1811648..1811667 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1811656 /Source="Nicolas_upshifts" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="upshifts" S_feature 1811671..1811735 /Source="Nicolas_S_feature" /locus_tag="new_2084124_2084188" /HighExp="BT, S7, B36, S8, S6, Pyr, G/S, B60, Glucon, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S729" promotor_-35 1811707..1811712 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1811728..1811746 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1811737 /Source="Nicolas_upshifts" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="upshifts" CDS 1811761..1812306 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8990290, 11717295, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 11717295, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="mother cell-specific membrane sporulation protein" /protein_id="NP_389792.1" /db_xref="EnsemblGenomes-Gn:BSU19110" /db_xref="EnsemblGenomes-Tr:CAB13803" /db_xref="GOA:P94497" /db_xref="InterPro:IPR014743" /db_xref="SubtiList:BG12269" /db_xref="UniProtKB/Swiss-Prot:P94497" /translation="MHLTLQSVYPAIIIIFFLYKKIKRSIGYQPLKPRWLFTRIILFS LFAFGLSIFSAIHPFLYGYLILGILGGWLLVFFAKKNISFEKRRGKIYFRTHIWVEVI LLTLFLSRFLYRVTELYLTSPDLNRLGSYSQSIGTDPLTIGVCFLIAVYYIGFSSFII KLSRNELEQHEYNKEKDILAR*" /label="yobW CDS" gene 1811761..1812306 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /label="yobW gene" downshifts 1812265 /Source="Nicolas_upshifts" /id="D1047" /incds=0 /nref=20 /ntot=63 /MaxReadThrough="3.56215" /MaxDrop="4.5413" /score="-4.21976438" /energy="-17.7" /TU="U1552,U1553" /idTUdmin="U1552" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS complement(1812333..1812656) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15948947, 16406068, 16430705, 19170879, 19995076, 25213752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16406068, 16430705, 19170879, 19995076, 25213752; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressor favouring Zn2+)" /protein_id="NP_389793.1" /db_xref="EnsemblGenomes-Gn:BSU19120" /db_xref="EnsemblGenomes-Tr:CAB13804" /db_xref="GOA:O31844" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13748" /db_xref="UniProtKB/Swiss-Prot:O31844" /translation="MTEFRETEQSAADLDEETLFLVAQTFKALSDPTRIRILHLLSQG EHAVNGIAEKLNLLQSTVSHQLRFLKNLRLVKSRREGTSIYYSPEDEHVLDVLQQMIH HTQHD*" /label="czrA CDS" gene complement(1812333..1812656) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /label="czrA gene" downshifts complement(1812340) /Source="Nicolas_upshifts" /id="D1048" /incds=0 /nref=73 /ntot=252 /MaxReadThrough="1.89304" /MaxDrop="4.873" /score="17.3750937" /energy="-18.6" /TU="NA" /idTUdmin="U1554" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1812677..1812696) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1812688) /Source="Nicolas_upshifts" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1812709..1812716) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1812777..1812783 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1812794 /Source="Nicolas_upshifts" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1812798..1812817 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1812850..1813527 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative murein fragments glycosidase" /protein_id="NP_389794.1" /db_xref="EnsemblGenomes-Gn:BSU19130" /db_xref="EnsemblGenomes-Tr:CAB13805" /db_xref="GOA:O34636" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13514" /db_xref="UniProtKB/Swiss-Prot:O34636" /translation="MKKKRKGCFAAAGFMMIFVFVIASFLLVLLFFNRDLIKKLPIDT KTIVLERLTDYKPLVEEELESQGLSNYTSLILGMMYQESKGKGNDPMQSSESLGLKRN EITDPQLSVKQGIKQFTLMYKTGKEKGVDLDTIIQSYNMGAGYIDFVAEHGGTHTEEL AKQYSEQQVKKNPDLYTCGGNAKNFRYPYCYGDYTYAEKVKEKTKTVEESLQVATLET MESKAHE*" /label="yocA CDS" gene 1812850..1813527 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /label="yocA gene" downshifts 1813519 /Source="Nicolas_upshifts" /id="D1049" /incds=0 /nref=207 /ntot=268 /MaxReadThrough="3.9729" /MaxDrop="8.52704" /score="-4.21976438" /energy="-17.7" /TU="U1555" /idTUdmin="U1555" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1813617..1814153) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19222757, 24214949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389795.1" /db_xref="EnsemblGenomes-Gn:BSU19140" /db_xref="EnsemblGenomes-Tr:CAB13806" /db_xref="GOA:O31845" /db_xref="InterPro:IPR007352" /db_xref="InterPro:IPR013833" /db_xref="SubtiList:BG13749" /db_xref="UniProtKB/Swiss-Prot:O31845" /translation="MNQTENKPKNYTGIVLTLTVLINGLIAVLFFMPKLDQFSHANIH ILPMLNAIFNSFTFIFLLAALIMIKQKNIKAHKRFILAAFTTTLLFLICYVTYHSIAE NTLYGGEGIMRPIYFFILITHICLSAIIVPLALFTLIRGFSMQVERHKKIARWTMPLW LYVSLTGVIVYLMISPYY*" /label="yozB CDS" gene complement(1813617..1814153) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /label="yozB gene" downshifts complement(1813640) /Source="Nicolas_upshifts" /id="D1050" /incds=0 /nref=175 /ntot=250 /MaxReadThrough="4.33842" /MaxDrop="7.96098" /score="14.7470642" /energy="-7.7" /TU="U1556" /idTUdmin="U1557" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1814180..1814199) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1814200) /Source="Nicolas_upshifts" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1814213..1814220) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1814290..1815072) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389796.1" /db_xref="EnsemblGenomes-Gn:BSU19150" /db_xref="EnsemblGenomes-Tr:CAB13807" /db_xref="SubtiList:BG13515" /db_xref="UniProtKB/Swiss-Prot:O34516" /translation="MAIDSLINKLQYVQLEPPDKILSLYLNTDMRDPEQQGGEWKIAL KSGFSRLKEYLAASDPEEEKCLDGIRAKMNQYLNAMGKDMPRSLVFFVSDSGIWEPIK LQVPVDTRFYWEETAVLDQLKGLRQTYPSTAFILTQQHEVKIIETVLGKIEAVERYEY DMINESWKNSHSAVDKAPPFEENRMREHVTENQSRLYKRLAASLDQKAAAKRWERMVI AGDKETADILDQHMNKPIHSKIQKNLLNENEHKVIEHLIKEA*" /label="yocB CDS" gene complement(1814290..1815072) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /label="yocB gene" downshifts complement(1814299) /Source="Nicolas_upshifts" /id="D1051" /incds=0 /nref=3 /ntot=38 /MaxReadThrough="5.37496" /MaxDrop="4.00348" /score="14.7470642" /energy="-7.7" /TU="U1557" /idTUdmin="U1557" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1815094..1815112) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1815113) /Source="Nicolas_upshifts" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1815126..1815132) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1815169..1815176 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1815191..1815210 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1815195 /Source="Nicolas_upshifts" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1815243..1815740 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389797.1" /db_xref="EnsemblGenomes-Gn:BSU19160" /db_xref="EnsemblGenomes-Tr:CAB13808" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13516" /db_xref="UniProtKB/Swiss-Prot:O35042" /translation="MFTVKEKNRQELEEELNDLEFQIYRMQENMKDLSKDAKVLGIDQ SKHDEWMIVSSIDDGQTCKIMLTDCKTAYRGKGCFSLVASYKDDAIHIGDIKGPPNHG FGSICMKYLKDIARDHNIPKVTGDIAKRDWNHVDRLIHFYEKHHFKVCIDHDTQSGSI KWVDL*" /label="yocC CDS" gene 1815243..1815740 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /label="yocC gene" promotor_-35 1815747..1815750 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1815766..1815785 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1815768 /Source="Nicolas_upshifts" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1815804..1816781 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /EC_number="3.4.17.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22516613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxypeptidase; aminoacid adenylate hydrolase (microcin resistance)" /protein_id="NP_389798.1" /db_xref="EnsemblGenomes-Gn:BSU19170" /db_xref="EnsemblGenomes-Tr:CAB13809" /db_xref="GOA:O35046" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13517" /db_xref="UniProtKB/Swiss-Prot:O35046" /translation="MYASKLKKGDEIRIVSPATSMSILSNEAKIQAKTALERLGYRVT IAEHANECNEFDSSSIESRVHDLHAAFFDPGVKAILTTLGGFNSNQLLRYLDYEKIKR HPKILCGYSDITALCNAIYQKTGLVTYSGPHFSTFAMKKGLDYTEEYFLSCCASDDPF EIHPSSEWSDDRWFLDQENRRFYPNNGPVVIQEGYAEGTLIGGNLCTLNLLQGTEYFP ETEHTILLIEDDYMSDIHMFDRDLQSLIHLPAFSHVKAILIGRFQKASNVSIDLVKAM IETKKELSGIPIIANINAGHTSPIATFPIGGTCRIEAISGTSRIWIDKH*" /label="yocD CDS" gene 1815804..1816781 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /label="yocD gene" downshifts 1816753 /Source="Nicolas_upshifts" /id="D1052" /incds=0 /nref=131 /ntot=256 /MaxReadThrough="3.77491" /MaxDrop="4.2254" /score="1.66373432" /energy="-9.5" /TU="U1558,U1559" /idTUdmin="U1558" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 1816878..1816885 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1816900..1816919 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1816907 /Source="Nicolas_upshifts" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1816943..1818001 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /EC_number="1.14.19.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid desaturase" /protein_id="NP_389799.1" /db_xref="EnsemblGenomes-Gn:BSU19180" /db_xref="EnsemblGenomes-Tr:CAB13810" /db_xref="GOA:O34653" /db_xref="InterPro:IPR005804" /db_xref="SubtiList:BG13518" /db_xref="UniProtKB/Swiss-Prot:O34653" /translation="MTEQTIAHKQKQLTKQVAAFAQPETKNSLIQLLNTFIPFFGLWF LAYLSLDVSYLLTLALTVIAAGFLTRIFIIFHDCCHQSFFKQKRYNHILGFLTGVLTL FPYLQWQHSHSIHHATSSNLDKRGTGDIWMLTVNEYKAASRRTKLAYRLYRNPFIMFI LGPIYVFLITNRFNKKGARRKERVNTYLTNLAIVALAAACCLIFGWQSFLLVQGPIFL ISGSIGVWLFYVQHTFEDSYFEADENWSYVQAAVEGSSFYKLPKLLQWLTGNIGYHHV HHLSPKVPNYKLEVAHEHHEPLKNVPTITLKTSLQSLAFRLWDEDNKQFVSFRAIKHI PVSLPPDSPEKQKLRKNA*" /label="desE CDS" gene 1816943..1818001 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /label="desE gene" S_feature 1818002..1818071 /Source="Nicolas_S_feature" /locus_tag="new_2090455_2090524" /HighExp="Cold, S8, LoTm, Sw, Paraq, BC, S7, S0, Oxctl, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.859" /TUlongSig="SigA, SigA" /TUlongPSig="0.984, 1" /label="S730" promotor_-35 1818055..1818061 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1818073..1818092 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1818073 /Source="Nicolas_upshifts" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1818121..1819233 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component thermosensor histidine kinase [DesR-DesK]" /protein_id="NP_389800.1" /db_xref="EnsemblGenomes-Gn:BSU19190" /db_xref="EnsemblGenomes-Tr:CAB13811" /db_xref="GOA:O34757" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="PDB:3EHF" /db_xref="PDB:3EHG" /db_xref="PDB:3EHH" /db_xref="PDB:3EHJ" /db_xref="PDB:3GIE" /db_xref="PDB:3GIF" /db_xref="PDB:3GIG" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUM" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13519" /db_xref="UniProtKB/Swiss-Prot:O34757" /translation="MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGII LTLLFFSVYRFAFVSKGWTIYLWGFLLIGISTASITLFSYIYFAFFIAYFIGNIKERV PFHILYYVHLISAAVAANFSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERL EEKLEDANERIAELVKLEERQRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAAR ELKSVQQTARTSLNEVRKIVSSMKGIRLKDELINIKQILEAADIMFIYEEEKWPENIS LLNENILSMCLKEAVTNVVKHSQAKTCRVDIQQLWKEVVITVSDDGTFKGEENSFSKG HGLLGMRERLEFANGSLHIDTENGTKLTMAIPNNSK*" /label="desK CDS" gene 1818121..1819233 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /label="desK gene" CDS 1819252..1819851 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [DesK]" /protein_id="NP_389801.1" /db_xref="EnsemblGenomes-Gn:BSU19200" /db_xref="EnsemblGenomes-Tr:CAB13812" /db_xref="GOA:O34723" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:4LDZ" /db_xref="PDB:4LE0" /db_xref="PDB:4LE1" /db_xref="PDB:4LE2" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13520" /db_xref="UniProtKB/Swiss-Prot:O34723" /translation="MISIFIAEDQQMLLGALGSLLNLEDDMEVVGKGTTGQDAVDFVK KRQPDVCIMDIEMPGKTGLEAAEELKDTGCKIIILTTFARPGYFQRAIKAGVKGYLLK DSPSEELANAIRSVMNGKRIYAPELMEDLYSEANPLTDREKEVLELVADGKNTKEIAQ ELSIKSGTVRNYISMILEKLEVKNRIEAITRSKEKGWFK*" /label="desR CDS" gene 1819252..1819851 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /label="desR gene" downshifts 1819789 /Source="Nicolas_upshifts" /id="D1053" /incds=1 /nref=1 /ntot=41 /MaxReadThrough="4.44811" /MaxDrop="2.78724" /score="23.648858" /energy="-15.4" /TU="U1560" /idTUdmin="U1560" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1819833 /Source="Nicolas_upshifts" /id="D1054" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.88273" /MaxDrop="3.38398" /score="23.648858" /energy="-15.4" /TU="NA" /idTUdmin="U1560" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1819873..1820371) /Source="Nicolas_S_feature" /locus_tag="new_2092326_2092824_c" /HighExp="S4, LoTm, S6, S3, S5, S8, S7, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.230296" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S731" downshifts complement(1819909) /Source="Nicolas_upshifts" /id="D1055" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.62146" /MaxDrop="5.61121" /score="23.7393309" /energy="-12.4" /TU="NA" /idTUdmin="U1563" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1820343..1820352 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1820355..1820373) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1820364..1820558 /Source="Nicolas_S_feature" /locus_tag="new_2092817_2093011" /HighExp="S6, S8, S7, BT, B36, Pyr, G/S, C30, S5, B60" /AntisenseName="yocH" /AntisenseCor="0.113870403460631" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S732" upshifts 1820364 /Source="Nicolas_upshifts" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1820365..1820384 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1820371) /Source="Nicolas_upshifts" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1820390..1820395) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1820446..1821309) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /EC_number="3.2.1.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:17307850, 20070526, 20487291, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17307850, 20070526, 20487291, 26102633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported cell wall lytic enzyme" /protein_id="NP_389802.1" /db_xref="EnsemblGenomes-Gn:BSU19210" /db_xref="EnsemblGenomes-Tr:CAB13813" /db_xref="GOA:O34669" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG13521" /db_xref="UniProtKB/Swiss-Prot:O34669" /translation="MKKTIMSFVAVAALSTTAFGAHASAKEITVQKGDTLWGISQKNG VNLKDLKEWNKLTSDKIIAGEKLTISSEETTTTGQYTIKAGDTLSKIAQKFGTTVNNL KVWNNLSSDMIYAGSTLSVKGQATAANTATENAQTNAPQAAPKQEAVQKEQPKQEAVQ QQPKQETKAEAETSVNTEEKAVQSNTNNQEASKELTVTATAYTANDGGISGVTATGID LNKNPNAKVIAVDPNVIPLGSKVYVEGYGEATAADTGGAIKGNKIDVFVPSKSDASNW GVKTVSVKVLN*" /label="walL CDS" gene complement(1820446..1821309) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /label="walL gene" downshifts complement(1820459) /Source="Nicolas_upshifts" /id="D1056" /incds=0 /nref=227 /ntot=262 /MaxReadThrough="2.55593" /MaxDrop="7.59881" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 1820515 /Source="Nicolas_upshifts" /id="D1057" /incds=1 /nref=8 /ntot=28 /MaxReadThrough="6.14664" /MaxDrop="3.95582" /score="23.648858" /energy="-15.4" /TU="U1562" /idTUdmin="U1560" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1820547) /Source="Nicolas_upshifts" /id="D1058" /incds=1 /nref=10 /ntot=161 /MaxReadThrough="7.34609" /MaxDrop="3.8459" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" S_feature 1820560..1821327 /Source="Nicolas_S_feature" /locus_tag="new_2093013_2093780" /HighExp="BT, S8, S6, Gly, S7, C30, G135, G/S, Fru, Pyr" /AntisenseName="yocH" /AntisenseCor="-0.12155468325348801" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S733" promotor_-35 1821305..1821309 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1821318..1821332 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1821329 /Source="Nicolas_upshifts" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1821348..1821367) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1821361) /Source="Nicolas_upshifts" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1821363..1821556) /Source="Nicolas_S_feature" /locus_tag="new_2093816_2094009_c" /HighExp="LoTm, HiOs, S8, C30, S2, G135, G180, T5.0H, S7, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S734" promotor_-35 complement(1821379..1821385) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1821557..1823332) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /EC_number="3.6.1.12" /experiment="publication(s) with functional evidences, PMID:11886746, 16385024, 22200572, 25246477, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 16385024, 22200572, 25246477, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase" /protein_id="NP_389803.1" /db_xref="EnsemblGenomes-Gn:BSU19220" /db_xref="EnsemblGenomes-Tr:CAB13814" /db_xref="GOA:O34748" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002121" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR006293" /db_xref="InterPro:IPR010997" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018982" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032284" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13522" /db_xref="UniProtKB/Swiss-Prot:O34748" /translation="MLHRAQSLLAHYFGYEKFRSGQDEAIRLVTEARQNTACIMPTGG GKSICYQIPALMFEGTTIVISPLISLMKDQVDALEEAGINAAYINSTQSNQEIYERLN GLKEGAYKLFYITPERLTSIEFIRILQGIDVPLVAIDEAHCISQWGHDFRPSYRNIEI LFRELHDKPVIMALTATATPEVHDDICKQLHIQKENTVYTGFSRENLTFKVVKGENKD RFIDEYVQNNRHEAGIVYTATRKEADRIYERLKRNQVRAGRYHGGLADDVRKEQQERF LNDELQVMVATSAFGMGIDKSNIRFVLHAQIPKDMESYYQEAGRAGRDGLASECVLLF SPQDIMVQRFLIEQSEHEEKQKQDLKKLRQMVDYCHTEDCLQRFILMYFGEKEPDACG QCGNCTDTRAAHDVTREAQMVLSCIIRMKERFGKTMVAQVLAGSKNKKVLENGFSDLS TYGILKHQSVGEISDFIEFLISDDFIRMSDGTFPTLFVSSKGRNVLKGELSVARKEAL KAAAITENDELFERLRMVRKEIAAEQGVPPFVVFSDQTLKEMSGKQPVNDDELLSIKG VGEQKRAKYGRLFLQEIQAYARMTD*" /label="recQ CDS" gene complement(1821557..1823332) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /label="recQ gene" S_feature complement(1823333..1823463) /Source="Nicolas_S_feature" /locus_tag="new_2095786_2095916_c" /HighExp="LoTm, G180, Cold, G135, G150, T5.0H, T4.0H, T3.30H, S2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S735" misc_RNA complement(1823456..1823658) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /product="6Sa RNA" /experiment="publication(s) with functional evidences, PMID:11886746, 15793584, 15811922, 22333917, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 15793584, 15811922, 22333917, 25576829, 26873600; Product type n : RNA" /label="ssrSA RNA" gene complement(1823456..1823658) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /label="ssrSA gene" downshifts complement(1823508) /Source="Nicolas_upshifts" /id="D1059" /incds=0 /nref=34 /ntot=297 /MaxReadThrough="4.06142" /MaxDrop="7.97725" /score="26.8190437" /energy="-12.7" /TU="U1566" /idTUdmin="U1568" /TUdmin=163 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1823656..1823675) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-10" upshifts complement(1823674) /Source="Nicolas_upshifts" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="upshifts" S_feature complement(1823676..1823868) /Source="Nicolas_S_feature" /locus_tag="new_2096129_2096321_c" /HighExp="dia5, Etha, dia15, Diami, S8, S7, C30, G180, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S736" promotor_-35 complement(1823688..1823695) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-35" CDS complement(1823897..1824523) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /EC_number="1.7.-.-" /experiment="publication(s) with functional evidences, PMID:11886746, 18208493, 22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 18208493, 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-dependent NADH-azoreductase" /protein_id="NP_389804.1" /db_xref="EnsemblGenomes-Gn:BSU19230" /db_xref="EnsemblGenomes-Tr:CAB13815" /db_xref="GOA:O35022" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13523" /db_xref="UniProtKB/Swiss-Prot:O35022" /translation="MSTVLFVKSSDRTAEEGVSTKLYEAFLAAYKENNPNDEVVELDL HKENLPYLGRDMINGTFKAGQGMEMTEDEKKQAAIADKYLNQFVKADKVVFAFPLWNF TVPAVLHTYVDYLSRAGVTFKYTQEGPVGLMGGKKVALLNARGGVYSEGPMAALEMSL NFMKTVLGFWGVQDLHTVVIEGHNAAPDQAQEIVEKGLQEAKDLAAKF*" /label="azoJ CDS" gene complement(1823897..1824523) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /label="azoJ gene" downshifts complement(1823913) /Source="Nicolas_upshifts" /id="D1060" /incds=0 /nref=68 /ntot=205 /MaxReadThrough="5.10353" /MaxDrop="5.66408" /score="1.15982687" /energy="-10.9" /TU="U1567,U1568" /idTUdmin="U1567" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1824557..1824576) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-10" upshifts complement(1824570) /Source="Nicolas_upshifts" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="upshifts" promotor_-35 complement(1824590..1824597) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-35" CDS complement(1824674..1825165) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 15496987, 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_389805.2" /db_xref="EnsemblGenomes-Gn:BSU19240" /db_xref="EnsemblGenomes-Tr:CAB13816" /db_xref="GOA:P80872" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR020458" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG13524" /db_xref="UniProtKB/Swiss-Prot:P80872" /translation="MALTKEQTQHLYHKLLDMQKELSGEKKETESMTEEVGELSNGVD NHMADHGTLVTDRMTDQTVKEIDRELLEEVNRALQKMKDGTYGVCEKTGQEIPYERLE AVPYARMTVEAQADVEDDLETDAPSYEREFHEQVKDLSNKETIDQKSSQTYEILDREQ DSK*" /label="yocK CDS" gene complement(1824674..1825165) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /label="yocK gene" downshifts complement(1824683) /Source="Nicolas_upshifts" /id="D1061" /incds=0 /nref=5 /ntot=49 /MaxReadThrough="7.79466" /MaxDrop="4.30433" /score="1.15982687" /energy="-10.9" /TU="U1568,U1573" /idTUdmin="U1571" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1825177..1825195) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-10" upshifts complement(1825189) /Source="Nicolas_upshifts" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="upshifts" promotor_-35 complement(1825209..1825215) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-35" CDS complement(1825240..1825572) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389806.1" /db_xref="EnsemblGenomes-Gn:BSU19250" /db_xref="EnsemblGenomes-Tr:CAB13817" /db_xref="SubtiList:BG13525" /db_xref="UniProtKB/Swiss-Prot:O34976" /translation="MKKMFRSLIRHCLKPELDKLRECEERLSVIEKQKQSSKQESEET YIHIETLNVEKVDYHLEFGELTIDELSGRLNIGATYYIPPEEKDKKCQRKPEAPSTPA VTIRSKRQ*" /label="yocL CDS" gene complement(1825240..1825572) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /label="yocL gene" S_feature complement(1825573..1825863) /Source="Nicolas_S_feature" /locus_tag="new_2098025_2098315_c" /HighExp="Salt, Cold, S3, S8, S4, S7, T5.0H, T3.30H, S6, T4.0H" /AntisenseName="yoyB" /AntisenseCor="0.489341986454357" /AntisenseRegPval="-16.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S737" promotor_-35 1825588..1825593 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-35" promotor_-10 1825608..1825626 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-10" upshifts 1825610 /Source="Nicolas_upshifts" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="upshifts" CDS 1825650..1825877 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097740.1" /db_xref="EnsemblGenomes-Gn:BSU19259" /db_xref="EnsemblGenomes-Tr:CAX52637" /db_xref="UniProtKB/Swiss-Prot:C0H429" /translation="MLPTNINISHLKTNSIGTGSSLTFGSAELRNRCSAIKRNNGFGE QNADGIVMVIPIESIDDRDVSDALSMKINHQ*" /label="yoyB CDS" gene 1825650..1825877 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /label="yoyB gene" CDS complement(1825864..1826340) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11150673, 23155385; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_389808.1" /db_xref="EnsemblGenomes-Gn:BSU19260" /db_xref="EnsemblGenomes-Tr:CAB13818" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG13526" /db_xref="UniProtKB/Swiss-Prot:O34321" /translation="MDFEKMKQWMEFAQQMYGGDFWKQVFDEDQKTPFMTNGQSPFPF AQQDQRGKGDASFPSMDIVDTVAEVQFLIYLPGYRKQDVHILSYGDYLVVKGQRFSYF NEQDFRQKEGKYGSFEKKIPLSDHLHGKMNAIFKDGILYITIQKDEGQAKTIVIDD*" /label="yocM CDS" gene complement(1825864..1826340) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /label="yocM gene" S_feature 1825878..1826385 /Source="Nicolas_S_feature" /locus_tag="new_2098330_2098837" /HighExp="S6, S5, S8, S7, S4, B36, BT, S3, T5.0H, LoTm" /AntisenseName="yocM" /AntisenseCor="0.54530996552252997" /AntisenseRegPval="-21.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.877" /TUlongSig="NA" /TUlongPSig="NA" /label="S738" S_feature complement(1826341..1826443) /Source="Nicolas_S_feature" /locus_tag="new_2098793_2098895_c" /HighExp="Cold, Salt, S8, T5.0H, S3, T-0.40H, T0.0H, S4, T4.0H, S6" /AntisenseName="yozN" /AntisenseCor="0.471443110130365" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S739" promotor_-35 1826358..1826363 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1826378..1826396 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1826387 /Source="Nicolas_upshifts" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="upshifts" CDS 1826407..1826670 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (mother cell in sporulation)" /protein_id="NP_389809.1" /db_xref="EnsemblGenomes-Gn:BSU19270" /db_xref="EnsemblGenomes-Tr:CAB13819" /db_xref="SubtiList:BG13761" /db_xref="UniProtKB/Swiss-Prot:O31846" /translation="MVQPTPYININIFMLKINSFENASAVNVGQNLLAEWQNSDKKNQ GYGQNFGDASGFMGTRSHVDDRDQIDSPASFESEAVNSSIKRK*" /label="yozN CDS" gene 1826407..1826670 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /label="yozN gene" promotor_-10 complement(1826423..1826442) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1826443) /Source="Nicolas_upshifts" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1826445..1826970) /Source="Nicolas_S_feature" /locus_tag="new_2098897_2099422_c" /HighExp="Salt, Cold, T-0.40H, T0.0H, T0.30H, T-1.10H, T-1.40H, T3.30H, T2.0H, S0" /AntisenseName="yocN" /AntisenseCor="-0.51964820699949898" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S740" promotor_-35 complement(1826456..1826460) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1826675..1826908 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (sporulation-related)" /protein_id="NP_389810.1" /db_xref="EnsemblGenomes-Gn:BSU19280" /db_xref="EnsemblGenomes-Tr:CAB13820" /db_xref="SubtiList:BG13527" /db_xref="UniProtKB/Swiss-Prot:O34855" /translation="MFFSPSVVNVGGFKINTMDRGSSLTLGPYQQVDYFLSAKINQGF GEENGDFTPLVVPISNVLDADLVDSNSAKNSVV*" /label="yocN CDS" gene 1826675..1826908 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /label="yocN gene" downshifts 1826895 /Source="Nicolas_upshifts" /id="D1062" /incds=0 /nref=62 /ntot=90 /MaxReadThrough="2.0117" /MaxDrop="7.59451" /score="5.68120132" /energy="-10.9" /TU="NA" /idTUdmin="U1570" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1826994..1827338) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved hypothetical phage protein" /protein_id="NP_389811.1" /db_xref="EnsemblGenomes-Gn:BSU19290" /db_xref="EnsemblGenomes-Tr:CAB13821" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG13762" /db_xref="UniProtKB/Swiss-Prot:O31847" /translation="MGIFSVSRSTDAKKLEALLVEGERIESIYKLRVDQICFTNKRII FFDNKMFSKKKVRVFLPYKTIESFAIQEAGMFDPDTGLLLMTRSKTFELEFAKDTDLS EVQAVLTKHLCS*" /label="yozO CDS" gene complement(1826994..1827338) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /label="yozO gene" downshifts complement(1827015) /Source="Nicolas_upshifts" /id="D1063" /incds=0 /nref=61 /ntot=217 /MaxReadThrough="4.58642" /MaxDrop="4.1868" /score="12.6520239" /energy="-9.6" /TU="U1572,U1573" /idTUdmin="U1574" /TUdmin=616 /isTUend="FALSE" /label="downshifts" S_feature complement(1827339..1827411) /Source="Nicolas_S_feature" /locus_tag="new_2099791_2099863_c" /HighExp="T0.30H, T0.0H, T1.0H, T-0.40H, T1.30H, T-1.10H, Salt, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S741" promotor_-10 complement(1827407..1827426) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1827411) /Source="Nicolas_upshifts" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1827413..1827516) /Source="Nicolas_S_feature" /locus_tag="new_2099865_2099968_c" /HighExp="T0.30H, T0.0H, T-0.40H, T1.0H, T1.30H, Salt, T-1.10H, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S742" promotor_-35 complement(1827440..1827445) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1827503..1827518) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1827516) /Source="Nicolas_upshifts" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1827531..1827540) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1827659) /Source="Nicolas_upshifts" /id="D1064" /incds=0 /nref=117 /ntot=269 /MaxReadThrough="5.5406" /MaxDrop="6.72115" /score="36.7697843" /energy="-10.7" /TU="U1574" /idTUdmin="U1576" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1827695..1827898) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389812.1" /db_xref="EnsemblGenomes-Gn:BSU19300" /db_xref="EnsemblGenomes-Tr:CAB13822" /db_xref="SubtiList:BG13750" /db_xref="UniProtKB/Swiss-Prot:O31848" /translation="MIHKNWLEKETIKKVKCVQTNAKKYIVNRVLTPGKEYEVKNETE EFLFVVDNTNKVGGYYKEYFEEM*" /label="yozC CDS" gene complement(1827695..1827898) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /label="yozC gene" promotor_-10 complement(1827919..1827938) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1827937) /Source="Nicolas_upshifts" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1827939..1828005) /Source="Nicolas_S_feature" /locus_tag="new_2100391_2100457_c" /HighExp="S7, S8, S6, S5, C30, S4, T4.0H, B60, BC, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.461" /TUlongSig="NA" /TUlongPSig="NA" /label="S743" promotor_-35 complement(1827954..1827961) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1827971..1827978 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-35" upshifts 1827990 /Source="Nicolas_upshifts" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="upshifts" misc_feature complement(1827992..1828004) /Source="Nicolas_upshift_promotors" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1827992..1828011 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-10" S_feature 1827995..1828127 /Source="Nicolas_S_feature" /locus_tag="new_2100447_2100579" /HighExp="BC, M0t90, M9-stat, S2, T2.30H, Sw, Lbstat, M40t90, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S744" upshifts complement(1828016) /Source="Nicolas_upshifts" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="upshifts" CDS 1828128..1829615 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /EC_number="1.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17555270, 23874669, 25409630, 26337367, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17555270, 23874669, 25409630, 26337367, 27797724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxypropionaldehyde dehydrogenase" /protein_id="NP_389813.1" /db_xref="EnsemblGenomes-Gn:BSU19310" /db_xref="EnsemblGenomes-Tr:CAB13823" /db_xref="GOA:O34660" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12582" /db_xref="UniProtKB/Swiss-Prot:O34660" /translation="MSSLTMQVTKRLETFLQGTKKLYIDGKFVPSASGATFDTPNPAT GETLMTLYEAQAADVDKAVKAARKAFDQGEWRTMSPASRSRLMYKLADLMEEHKTELA QLETLDNGKPINETTNGDIPLAIEHMRYYAGWCTKITGQTIPVSGAYFNYTRHEPVGV VGQIIPWNFPLLMAMWKMGAALATGCTIVLKPAEQTPLSALYLAELIDQAGFPAGVIN IIPGFGEDAGEALTNHEAVDKIAFTGSTEIGKKIMSTAAKSIKRVTLELGGKSPNILL PDANLKKAIPGALNGVMFNQGQVCCAGSRVFIHKDQYDEVVDEMASYAESLRQGAGLH KDTQIGPLVSKEQHERVLSYIQKGKDEGAKAVTGGSCPFEAGYFVAPTVFANVEDEMT IAKEEIFGPVLTAIPYETVDEVIERANHSEYGLAAGLWTENVKQAHYIADRLQAGTVW VNCYNVFDAASPFGGYKQSGLGREMGSYALDNYTEVKSVWVNLED*" /label="dhaS CDS" gene 1828128..1829615 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /label="dhaS gene" promotor_-10 complement(1828571..1828588) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1828577) /Source="Nicolas_upshifts" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1828601..1828609) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1829601 /Source="Nicolas_upshifts" /id="D1065" /incds=0 /nref=163 /ntot=260 /MaxReadThrough="3.66831" /MaxDrop="7.01026" /score="24.6079855" /energy="-7.1" /TU="U1575" /idTUdmin="U1575" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1829663..1829668 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1829684..1829702 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1829689 /Source="Nicolas_upshifts" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="upshifts" CDS 1829716..1831614 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /EC_number="4.2.1.137" /EC_number="5.4.99.17" /function="16.13: Shape" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2253626, 18436644, 18630919, 21627333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2253626, 18436644, 18630919, 21627333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="squalene-hopene cyclase, sporulenol synthase (spore protection)" /protein_id="NP_389814.2" /db_xref="EnsemblGenomes-Gn:BSU19320" /db_xref="EnsemblGenomes-Tr:CAB13824" /db_xref="GOA:Q796C3" /db_xref="InterPro:IPR008930" /db_xref="InterPro:IPR018333" /db_xref="InterPro:IPR032696" /db_xref="InterPro:IPR032697" /db_xref="SubtiList:BG12679" /db_xref="UniProtKB/Swiss-Prot:Q796C3" /translation="MGTLQEKVRRFQKKTITELRDRQNADGSWTFCFEGPIMTNSFFI LLLTSLDEGENEKELISSLAAGIHAKQQPDGTFINYPDETRGNLTATVQGYVGMLASG CFHRTEPHMKKAEQFIISHGGLRHVHFMTKWMLAANGLYPWPALYLPLSLMALPPTLP IHFYQFSSYARIHFAPMAVTLNQRFVLINRNISSLHHLDPHMTKNPFTWLRSDAFEER DLTSILLHWKRVFHAPFAFQQLGLQTAKTYMLDRIEKDGTLYSYASATIYMVYSLLSL GVSRYSPIIRRAITGIKSLVTKCNGIPYLENSTSTVWDTALISYALQKNGVTETDGSV TKAADFLLERQHTKIADWSVKNPNSVPGGWGFSNINTNNPDCDDTTAVLKAIPRNHSP AAWERGVSWLLSMQNNDGGFSAFEKNVNHPLIRLLPLESAEDAAVDPSTADLTGRVLH FLGEKVGFTEKHQHIQRAVKWLFEHQEQNGSWYGRWGVCYIYGTWAALTGMHACGVDR KHPGIQKALRWLKSIQNDDGSWGESCKSAEIKTYVPLHRGTIVQTAWALDALLTYENS EHPSVVKGMQYLTDSSSHSADSLAYPAGIGLPKQFYIRYHSYPYVFSLLAVGKYLDSI EKETANET*" /label="sqhC CDS" gene 1829716..1831614 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /label="sqhC gene" promotor_-10 complement(1830659..1830678) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1830667) /Source="Nicolas_upshifts" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1830692..1830701) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1831604..1832449 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /EC_number="1.15.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 20233928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Fe2+-dependent)" /protein_id="NP_389815.1" /db_xref="EnsemblGenomes-Gn:BSU19330" /db_xref="EnsemblGenomes-Tr:CAB13825" /db_xref="GOA:O35023" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="SubtiList:BG12676" /db_xref="UniProtKB/Swiss-Prot:O35023" /translation="MKRESYQAEMFNWCEALKDQIQKRGQLDQFEDQIDKMIEALEDD QTTEEDWYKQAAALYRDITESDDTSERRAYVPIGKHVLPKLPYKYSALEPYISRDIMI LHHTKHHQSYVDGLNKAESELKKARATKNYDLITHWERELAFHGAGHYLHSIFWFSMH PNGKRRPTGALFQMIDLSFGSYSAFKEHFTQASKKVEGVGWAILVWAPRSGRLEILTA EKHQLFSQWDVIPLLPLDVWEHAYYLQYKNDRASYVDHWWNVVDWREAEKRFEQAKEV VWKLY*" /label="sodF CDS" gene 1831604..1832449 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /label="sodF gene" S_feature 1832450..1833956 /Source="Nicolas_S_feature" /locus_tag="new_2104902_2106408" /HighExp="S5, S6, S4, S8, S3, S7, T5.0H, B36, BT, T4.0H" /AntisenseName="yocR" /AntisenseCor="-0.62866346519731298" /AntisenseRegPval="-30.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S745" CDS complement(1832482..1833819) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_389816.1" /db_xref="EnsemblGenomes-Gn:BSU19340" /db_xref="EnsemblGenomes-Tr:CAB13826" /db_xref="GOA:O34383" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13528" /db_xref="UniProtKB/Swiss-Prot:O34383" /translation="MKEANQWSSKLGFILAAAGSAIGLGAIWKFPYVAGTSGGGAFLL IFILFTVLIGLPLLLGEFIIGRRTQKDAVQSYKTLAPGTKWHWIGYLGMVTCFILLSF YSVVGGWILIYIIKGFTGGLSQTSGFDTIFASTISNPYLAVGGQLLFMVVTILVVAKG VSSGIEKASQVLMPALFLLFIILMVRSVTLDGAMEGIKFFLMPDLTAIDANTILYAMG QSFFLLSVGVSVMVTYSAYLEKQENLVQSAVSVTVMNMLVAVMAGIAIFPAVFSFGLK PDQGPVLLFNVLPTVFNQMPFGIIFLLAFLLLFLFAALTSAFSMLEILVAVLSKGDIN KRKRFAWLGGIAIFIVGVPSALSYGVLSDVTIFHLSIFDAADYLVSNILMPLGALLIS IFVPLKIPKQDLFDELKSGSNLKRKWFAVWLLLIRYLSPVAIIIVFLHVIGIF*" /label="yocR CDS" gene complement(1832482..1833819) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /label="yocR gene" downshifts complement(1832493) /Source="Nicolas_upshifts" /id="D1066" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="0.83968" /MaxDrop="2.44824" /score="27.8372036" /energy="-11.1" /TU="NA" /idTUdmin="U1580" /TUdmin=154 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1833847..1833866) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1833862) /Source="Nicolas_upshifts" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1833864..1835022) /Source="Nicolas_S_feature" /locus_tag="new_2106316_2107474_c" /HighExp="M9-stat, T1.30H, B60, T1.0H, T2.0H, T0.30H, T2.30H, T3.0H, T3.30H, Etha" /AntisenseName="yocS" /AntisenseCor="-6.3575129468026695E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S746" promotor_-35 complement(1833881..1833888) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1833940..1833943 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1833958..1833977 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1833958 /Source="Nicolas_upshifts" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="upshifts" CDS 1834038..1835003 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent symporter" /protein_id="NP_389817.1" /db_xref="EnsemblGenomes-Gn:BSU19350" /db_xref="EnsemblGenomes-Tr:CAB13827" /db_xref="GOA:O34524" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG13529" /db_xref="UniProtKB/Swiss-Prot:O34524" /translation="MDIIRKISHFAGQTFGIWVIVFAVLGFSFPSLFTWISSYITIFL GIIMFGMGLTLQADDFKELVRKPWQVIIGVIAQYTIMPLVAFGLAFGLHLPAEIAVGV ILVGCCPGGTASNVMTFLAKGNTALSVAVTTISTLLAPVVTPLLIMLFAKEWLPVSPG SLFISILQAVLFPIIAGLIVKMFFRKQVAKAVHALPLVSVIGIVAIVSAVVSGNRENL LQSGLLIFSVVILHNGIGYLLGFLCAKLLKMDYPSQKAIAIEVGMQNSGLGAALATAH FSPLSAVPSAIFSVWHNLSGSMLATYWSKKVKKKQAGSKSSNLSL*" /label="yocS CDS" gene 1834038..1835003 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /label="yocS gene" downshifts 1834991 /Source="Nicolas_upshifts" /id="D1067" /incds=0 /nref=42 /ntot=166 /MaxReadThrough="3.53218" /MaxDrop="5.09676" /score="30.279305" /energy="-16.4" /TU="U1581" /idTUdmin="U1581" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1835053..1836306) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /EC_number="2.3.1.61" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417, 22720735, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417, 22720735, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase complex (dihydrolipoamide transsuccinylase, E2 subunit)" /protein_id="NP_389818.2" /db_xref="EnsemblGenomes-Gn:BSU19360" /db_xref="EnsemblGenomes-Tr:CAB13828" /db_xref="GOA:P16263" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR006255" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10273" /db_xref="UniProtKB/Swiss-Prot:P16263" /translation="MAEIKVPELAESISEGTIAQWLKQPGDYVEQGEYLLELETDKVN VELTAEESGVLQEVLKDSGDTVQVGEIIGTISEGAGESSAPAPTEKTESKESVKEEKQ AEPAAQEVSEEAQSEAKSRTIASPSARKLAREKGIDLSQVPTGDPLGRVRKQDVEAYE KPASKPAPQQKQQPQAQKAQQSFDKPVEVQKMSRRRQTIAKRLVEVQQTSAMLTTFNE VDMTAVMNLRKRRKDQFFEQNEVKLGFMSFFTKAVVAALKKYPLLNAEIQGDELIVKK FYDIGIAVAADEGLVVPVVRDADRLTFAGIEKEIGELAKKARNNKLTLSELQGGSFTI TNGGTFGSLMSTPILNSPQVGILGMHKIQLRPVAIDEERFENRPMMYIALSYDHRIVD GKEAVGFLVTIKNLLEDPEQLLLEG*" /label="odhB CDS" gene complement(1835053..1836306) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /label="odhB gene" downshifts complement(1835067) /Source="Nicolas_upshifts" /id="D1068" /incds=0 /nref=200 /ntot=253 /MaxReadThrough="5.25481" /MaxDrop="7.42366" /score="11.7726103" /energy="-16.4" /TU="U1582" /idTUdmin="U1582" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" CDS complement(1836322..1839156) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /EC_number="1.2.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase (E1 subunit)" /protein_id="NP_389819.3" /db_xref="EnsemblGenomes-Gn:BSU19370" /db_xref="EnsemblGenomes-Tr:CAB13829" /db_xref="GOA:P23129" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR011603" /db_xref="InterPro:IPR023784" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR031717" /db_xref="InterPro:IPR032106" /db_xref="SubtiList:BG10272" /db_xref="UniProtKB/Swiss-Prot:P23129" /translation="MFQNSMKQRMNWEDFYGPNLGYALELYDQYTQDPNSIDPDLKEM FDELGAPPSDIKEASGTKEKGRVTADLIQKIASAVRLAEDIRTYGHLNASVNPLRKDE KKSELFPLSDYGLTEEEIKAIPASVICKDAPKNISNGLEAIQYLRNTYKRTISFEFDH VHDFKEREWLTRKIESGELFQKNSAEKLSAVLERLTEVEGFEQFLHRTFVGQKRFSIE GLDALVPVLDDIIAQSVKSGTTSVNIGMAHRGRLNVLAHVLGKPYEIIFSEFQHAPNK DLVPSEGSIGISYGWTGDVKYHLGANRELQDAETKSARITLANNPSHLEFINPIVEGS TRAAQETRTQSGYPVQDETKSLAILIHGDAAFPGEGIVAETLNLSSLKGYQVGGAIHI IANNMIGFTTESAESRSTKYASDLAKGYEIPIVHVNADDPEACLSAVKFAVEYRKTFN KDFLIDLIGYRRYGHNEMDEPSTTQPMLYDAVRKHPTVKQIFAEKLVKEGVVTEEVVQ NIEKSVTKRIEDAYQKVPSKKEHTACEIELPEPVSNGFPDVDTSIDFDVLRKLNGELI NWPESFNVFGKLKRILERRAKAFDDDRKVEWSLAESLAFASILKDGTPIRLTGQDSER GTFAQRNLVLHDSETGKEFVPLHHLSDCSTSFAVHNSPLSEGSVLGFEYGYNVHSPET LVLWEAQYGDFANAAQVYFDQFISAGRAKWGQKSGLVMLLPHGYEGQGPEHSSGRIER FLQLAAENNWTVANLTSAAQYFHILRRQAKMLLREEIRPLVIMTPKSLLRNPNTVSEV QELSESRFQPVYEQSGLSHDYEKVTRLVLSSGKVSIDISDHFNKLEDGKEWLHIARIE QLYPFPAKGVKELFAKLPNLKEIVWVQEEPQNMGAWGYISPYLTEIAPEGVSVQYIGR RRRSSPAEGDPTVHKKEQERIVSDSLTRKN*" /label="odhA CDS" gene complement(1836322..1839156) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /label="odhA gene" promotor_-10 complement(1839251..1839270) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1839266) /Source="Nicolas_upshifts" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1839268..1839384) /Source="Nicolas_S_feature" /locus_tag="new_2111720_2111836_c" /HighExp="dia15, G150, G135, H2O2, Lbexp, dia0, Oxctl, LBGtran, G180, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S747" promotor_-35 complement(1839285..1839292) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1839385..1841301) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23087684; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative activator of nitric oxide reductase" /protein_id="NP_389820.2" /db_xref="EnsemblGenomes-Gn:BSU19380" /db_xref="EnsemblGenomes-Tr:CAB13830" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG13567" /db_xref="UniProtKB/Swiss-Prot:O31849" /translation="MKFIKFNDSTIDSFLFMMLTDLAKTLTKSEAVEVEYGVQSYYNP FEKKIYMSHFWKDRAAEDMEAGLKSDVYLRSVGTRYSSLHEFANFLNDIHRHLTFKSF AKQLFMLLEDIRIEECIKRERPGTKHVFAKRKDMYRKHFSTQLTLNLERSIFTDALFC AIYFKLTAESPLETLPSMREDIDLMRPFIEQQLLRVYEADSTRQVLKIVEDLMDGLEE VLDKDMLNTYFFLPELDYAKAAEQPLFEEEKKAPKLSDDITLPKQSDGDEDIHEEEMP TWHRETEAPSKSFLQFDIEHGAKSDLGKDASREGDDGDQALGSVQGSARQTKRKDYSK LEALESQKDQPNGAGMADGKENKYAFPIYKEPQPATSEEELSYKQQAKTIESYQKRLK QMIQKTLEHKKTLPRTDLHAGRLNNKLLRYFTERNPRLFYKKQEPSSEIDAVFTLLVD CSASMFDKMDETKRGIVLFHEALKSVAVPHQIVGFWEDTNDATEKSQPNYFNTVIPFQ SSLRQDSGPAIMQLEPEEDNRDGYAIRQMTKKMLHRSEAQKFLIVFSDGEPAAFGYEQ NGIVDTSEAVIEARKRGIEVINVFLSNSEIEESQMKTIQDMYGKFSIFVPDVDQLPDV LYPLLKKLLHKSIG*" /label="yojO CDS" gene complement(1839385..1841301) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /label="yojO gene" CDS complement(1841312..1842226) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15491156, 23087684; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nitric-oxide reductase associated protein" /protein_id="NP_389821.1" /db_xref="EnsemblGenomes-Gn:BSU19390" /db_xref="EnsemblGenomes-Tr:CAB13831" /db_xref="GOA:O31850" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011704" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13566" /db_xref="UniProtKB/Swiss-Prot:O31850" /translation="MNRKGNLSMTTQLQHLTLPEDIQQKLLSYKEQPISPEFQSLIGT SGYEAEDEAILFDAIIALAMGKNVLLKGPTGSGKTKLAETLSSYFHKPMHSVNCSVDL DAEALVGYKTIENQSGQATIEFVSGPVTKAMKEGHFLYIDEINMAKPETLPILNGVLD YRKMMTNPFTGEVIRAKSGFGVIAAINEGYVGTVPLNEALKNRFVIIDVPYIKGELLK QVLMSQSALKDEKLIDRFITLSSDLIVQANNGQVSEEAASIRALIDTCDLAAYIPPRR AIERGIVEKLDDDREKAAVRNIAETLFE*" /label="yojN CDS" gene complement(1841312..1842226) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /label="yojN gene" promotor_-10 complement(1842230..1842249) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-10" upshifts complement(1842245) /Source="Nicolas_upshifts" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="upshifts" promotor_-35 complement(1842266..1842270) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-35" CDS complement(1842290..1842880) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /EC_number="1.15.1.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15897454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15897454; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="superoxide dismutase (exported lipoprotein)" /protein_id="NP_389822.1" /db_xref="EnsemblGenomes-Gn:BSU19400" /db_xref="EnsemblGenomes-Tr:CAB13832" /db_xref="GOA:O31851" /db_xref="InterPro:IPR001424" /db_xref="InterPro:IPR024134" /db_xref="InterPro:IPR036423" /db_xref="PDB:1S4I" /db_xref="PDB:1U3N" /db_xref="PDB:1XTL" /db_xref="PDB:1XTM" /db_xref="SubtiList:BG13565" /db_xref="UniProtKB/Swiss-Prot:O31851" /translation="MHRLLLLMMLTALGVAGCGQKKPPDPPNRVPEKKVVETSAFGHH VQLVNREGKAVGFIEIKESDDEGLDIHISANSLRPGASLGFHIYEKGSCVRPDFESAG GPFNPLNKEHGFNNPMGHHAGDLPNLEVGADGKVDVIMNAPDTSLKKGSKLNILDEDG SAFIIHEQADDYLTNPSGNSGARIVCGALLGNNEKQ*" /label="sodC CDS" gene complement(1842290..1842880) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /label="sodC gene" CDS complement(1842973..1844217) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /EC_number="3.5.1.-" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 22139507" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 22139507; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan hydrolase (cell wall-binding d,l-endopeptidase)" /protein_id="NP_389823.1" /db_xref="EnsemblGenomes-Gn:BSU19410" /db_xref="EnsemblGenomes-Tr:CAB13833" /db_xref="GOA:O31852" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13564" /db_xref="UniProtKB/Swiss-Prot:O31852" /translation="MKKKIVAGLAVSAVVGSSMAAAPAEAKTIKVKSGDSLWKLSRQY DTTISALKSENKLKSTVLYVGQSLKVPESSKKSTTSPSNSSKTSTYTVAYGDSLWMIA KNHKMSVSELKSLNSLSSDLIRPGQKLKIKGTSSSSGSNGSKKNSGSNSSGSSKSTYT VKLGDSLWKIANSLNMTVAELKTLNGLTSDTLYPKQVLKIKGSSSPKNGNSGSKKPSN SNPSKTTTYKVKAGDSLWKIANRLGVTVQSIRDKNNLSSDVLQIGQVLTISGASKSNP SNPTKPTKPKDNSGSNIQIGSKIDRMITEAKKYVGVPYRWGGNTPAGFDCSGFIYYLI NNVSSISRLSTAGYWNVMQKVSQPSVGDFVFFTTYKSGPSHMGIYLGGGDFIHASSSG VDISNLSNSYWKQRYLGARSYF*" /label="cwlS CDS" gene complement(1842973..1844217) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /label="cwlS gene" downshifts complement(1842975) /Source="Nicolas_upshifts" /id="D1069" /incds=0 /nref=20 /ntot=183 /MaxReadThrough="4.09529" /MaxDrop="3.77828" /score="11.0350171" /energy="-4.7" /TU="U1584,U1585" /idTUdmin="U1585" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1844280..1844298) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1844293) /Source="Nicolas_upshifts" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1844295..1844515) /Source="Nicolas_S_feature" /locus_tag="new_2116747_2116967_c" /HighExp="S2, Lbstat, T2.30H, M0t90, HiOs, T3.0H, Etha, M40t90, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S748" promotor_-35 complement(1844311..1844318) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1844501..1844519) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1844515) /Source="Nicolas_upshifts" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1844531..1844539) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1844599..1845816) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /EC_number="2.4.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative YDP-glycosyltransferase" /protein_id="NP_389824.2" /db_xref="EnsemblGenomes-Gn:BSU19420" /db_xref="EnsemblGenomes-Tr:CAB13834" /db_xref="GOA:O31853" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG13563" /db_xref="UniProtKB/Swiss-Prot:O31853" /translation="MANVLMIGFPGEGHINPSIGVMKELKSRGENITYYAVKEYKEKI TALDIEFREYHDFRGDYFGKNATGDEERDFTEMLCAFLKACKDIATHIYEEVKHESYD YVIYDHHLLAGKVIANMLKLPRFSLCTTFAMNEEFAKEMMGAYMKGSLEDSPHYESYQ QLAETLNADFQAEIKKPFDVFLADGDLTIVFTSRGFQPLAEQFGERYVFVGPSITERA GNNDFPFDQIDNENVLFISMGTIFNNQKQFFNQCLEVCKDFDGKVVLSIGKHIKTSEL NDIPENFIVRPYVPQLEILKRASLFVTHGGMNSTSEGLYFETPLVVIPMGGDQFVVAD QVEKVGAGKVIKKEELSESLLKETIQEVMNNRSYAEKAKEIGQSLKAAGGSKKAADSI LEAVKQKTQSANA*" /label="yojK CDS" gene complement(1844599..1845816) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /label="yojK gene" downshifts complement(1844625) /Source="Nicolas_upshifts" /id="D1070" /incds=0 /nref=14 /ntot=145 /MaxReadThrough="1.49168" /MaxDrop="4.07727" /score="9.41396656" /energy="-14.4" /TU="NA" /idTUdmin="U1586" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1845849..1845868) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1845857) /Source="Nicolas_upshifts" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1845882..1845889) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1846052..1846675) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /EC_number="2.7.7.85" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:21566650, 23192352, 24939848, 27252699, 27790204, 28751888" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21566650, 23192352, 24939848, 27252699, 27790204, 28751888; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore diadenylate cyclase" /protein_id="NP_389825.3" /db_xref="EnsemblGenomes-Gn:BSU19430" /db_xref="EnsemblGenomes-Tr:CAB13835" /db_xref="GOA:O31854" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR019457" /db_xref="InterPro:IPR034693" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG13562" /db_xref="UniProtKB/Swiss-Prot:O31854" /translation="MKAMRYEQISENAFKGKIQVYLEQILGDASLILKTLHEKDQCLL CELDDLGHVFQDMQGIASSFYLQSYIEEFTPAFIELAKAIKALSEHKHGALIVIERAD PVERFIQKGTSLHAEISSSLIESIFFPGNPLHDGALLVRENKLVSAANVLPLTTKEVD IHLGTRHRAALGMSGYTDALVLVVSEETGKMSFAKDGVLYPLISPRT*" /label="cdaS CDS" gene complement(1846052..1846675) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /label="cdaS gene" S_feature complement(1846676..1846826) /Source="Nicolas_S_feature" /locus_tag="new_2119128_2119278_c" /HighExp="S8, S5, S7, S6, Etha, S4, M9-stat, S3, C30, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S749" promotor_-35 1846702..1846708 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1846714 /Source="Nicolas_upshifts" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1846722..1846733 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1846740..1846748 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1846756..1846856 /Source="Nicolas_upshift_promotors" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 1846760..1846778 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1846771 /Source="Nicolas_upshifts" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1846809..1846827) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1846816..1846901 /Source="Nicolas_S_feature" /locus_tag="new_2119268_2119353" /HighExp="S8, S7, S4, S5, S6, BT, S3, T5.0H, S2, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigGF" /TUshortPSig="0.00699, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S750" upshifts 1846816 /Source="Nicolas_upshifts" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1846826) /Source="Nicolas_upshifts" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1846843..1846849) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1846877..1846884 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1846897..1846916 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1846903 /Source="Nicolas_upshifts" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="upshifts" CDS 1846941..1848299 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14766544, 15849754, 15855508, 16850406, 16954325, 17114254; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+-driven efflux MatE family protein" /protein_id="NP_389826.1" /db_xref="EnsemblGenomes-Gn:BSU19440" /db_xref="EnsemblGenomes-Tr:CAB13836" /db_xref="GOA:O31855" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13561" /db_xref="UniProtKB/Swiss-Prot:O31855" /translation="MKETQNAREKIKQLLHILIPIFITQAGLSLITFLDTVMSGKVSP ADLAGVAIGSSLWTPVYTGLAGILMAVTPIVAQLLGAEKKQKIPFTVLQAVYVAALLS IAVLVIGYAAVDLILGRLNLDIHVHQIAKHFLGFLSLGIFPLFVYTVLRSFIDSLGKT RVTMMITLSSLPINFVLNYVFIFGKFGMPALGGVGAGLASALTYWCICIISFFIIHKN APFSEYGIFLTMYKFSWKACKNLLKIGLPIGFAVFFETSIFAAVTLLMSHFHTVTIAS HQAAMNFASLLYMLPLSVSMALTIVVGFEAGAARFKDARSYSLIGIMMAIGFSLFTAA CILLFREQIAGMYTSDPDVLRLTQHFLIYALFFQLSDAVAAPIQGALRGYKDVNYTLA AAFVSYWVIGLPVGYMVGTFTSLGAFGYWIGLIAGLAAGAVGLFFRLAKLQKRYSQKQ HI*" /label="mdtK CDS" gene 1846941..1848299 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /label="mdtK gene" promotor_-10 complement(1847283..1847294) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1847288) /Source="Nicolas_upshifts" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1847308..1847314) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1848315..1849163 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665, 20935101, 22287516, 24599254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665, 20935101, 22287516, 24599254; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-antagonist of RsbT; component of the anxiosome (stressosome)" /protein_id="NP_389827.1" /db_xref="EnsemblGenomes-Gn:BSU19450" /db_xref="EnsemblGenomes-Tr:CAB13837" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG13560" /db_xref="UniProtKB/Swiss-Prot:O31856" /translation="MAKNKKLFEYLSQHAETISSTWYETIEETDPNSIYASTDPVVIH NLKSQNLAFNYKINRIFIDDEDVYLPILKEWAFEVTQDQEHLKTPIHYIIREFVRVRD LYVSYVKEFVHLNQNTVKSEEAEDLYHALIKAFDLVIHIFIEEMYKNTSLQLQAQKDM ITELSAPVIVLFHSVGLLPLIGDIDTVRAKLIMENTLHQCAKKKVTQLYIDLSGVAVI DTMVAHQLFSLIEALRLIGVSSTLSGIRPEIAQTAVQLGLSFEGISLRSTLASAIASD LKLKKV*" /label="rsbRC CDS" gene 1848315..1849163 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /label="rsbRC gene" promotor_-10 complement(1848579..1848598) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1848586) /Source="Nicolas_upshifts" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1848612..1848620) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1849126 /Source="Nicolas_upshifts" /id="D1071" /incds=0 /nref=10 /ntot=138 /MaxReadThrough="1.62054" /MaxDrop="3.13267" /score="12.3887642" /energy="-14" /TU="NA" /idTUdmin="U1591" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1849158) /Source="Nicolas_upshifts" /id="D1072" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="1.55562" /MaxDrop="4.60101" /score="23.8391861" /energy="-13.7" /TU="NA" /idTUdmin="U1594" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1849189..1849854) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /EC_number="3.5.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15136574, 20308541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15136574, 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate N-acetylglucosamine deacetylase (second enzyme)" /protein_id="YP_054582.2" /db_xref="EnsemblGenomes-Gn:BSU19460" /db_xref="EnsemblGenomes-Tr:CAB13838" /db_xref="GOA:O31857" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023841" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG13559" /db_xref="UniProtKB/Swiss-Prot:O31857" /translation="MKEHVLVILPHPDDESYGVAGLIALNRKKDIPVTYACATLGEMG RNMGDPFFANRETLPLLRKQELINACKEMDINDLRMLGLRDKTLEFEDDEYLADIMEE IIDDVKPSLIVTFYPGHGVHPDHDACGEAVIRALYRKKKEDRPRTICMAITRNREEVL GEADVVLDIKEVADIKMNALRAHRTQTEGMLRELEEKLKNNEPVMATWFEEEIYWTYQ WND*" /label="bshBB CDS" gene complement(1849189..1849854) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /label="bshBB gene" downshifts complement(1849203) /Source="Nicolas_upshifts" /id="D1073" /incds=0 /nref=189 /ntot=251 /MaxReadThrough="3.68743" /MaxDrop="7.13247" /score="23.8391861" /energy="-13.7" /TU="U1594" /idTUdmin="U1596" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1849873..1850223) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (bacillithiol synthesis operon)" /protein_id="NP_389829.1" /db_xref="EnsemblGenomes-Gn:BSU19470" /db_xref="EnsemblGenomes-Tr:CAB13839" /db_xref="InterPro:IPR014934" /db_xref="InterPro:IPR036492" /db_xref="PDB:1NJH" /db_xref="SubtiList:BG13558" /db_xref="UniProtKB/Swiss-Prot:O31858" /translation="MKAIIKEDVQASLERYADRPVYIHLETTTGSYSAHLNEKNMTVV AYIRNAKVTYHQAKIKGNGPYRVGLKTEEGWIYAEGLTEYTVDEENRLLMAGHLPGGK LAISLQISEKPFTV*" /label="yojF CDS" gene complement(1849873..1850223) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /label="yojF gene" CDS complement(1850220..1850498) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097741.1" /db_xref="EnsemblGenomes-Gn:BSU19479" /db_xref="EnsemblGenomes-Tr:CAX52638" /db_xref="UniProtKB/Swiss-Prot:O68260" /translation="MDNDKEIVKAYASLWNNRSLAHDDAEAVAEAIDLELLDKRTHPR LRKPMLEKYFAAIQRIVNSQLEPAVKYQLVKLHTERAEYLKEERGEQS*" /label="yoyC CDS" gene complement(1850220..1850498) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /label="yoyC gene" promotor_-10 complement(1850525..1850544) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1850541) /Source="Nicolas_upshifts" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1850559..1850565) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1850574..1851470) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636, 23944997; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative N-acetylated toxic metabolites" /protein_id="NP_389830.2" /db_xref="EnsemblGenomes-Gn:BSU19480" /db_xref="EnsemblGenomes-Tr:CAB13840" /db_xref="GOA:O31859" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004626" /db_xref="SubtiList:BG13557" /db_xref="UniProtKB/Swiss-Prot:O31859" /translation="MQHAETKKGVIYTAVSFIMWGLFPLYWKLLEQLPALDILAHRII WSFVFMCIVLFFLRQWKIGWQELRSLKKNGGILSLFLASILISINWFVYIWAVNHGFL LEASLGYYINPLVSVLLGILFLKEKLNRLQLVAVSIAAAGVIISAFQYGSIPYVALLL AFSFGLYGLSKKRTSLPSAIGLTLETFMIMPIALGYLLFSGHVQPAGAESGGTWLLLF LAGVFTALPLLLFAEGAKRLPLYQVGILQYIAPTITLLIGLFVYHEPFSSSKAFTFSC IWAALLLFTFSQVKWKRASKSH*" /label="yojE CDS" gene complement(1850574..1851470) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /label="yojE gene" promotor_-35 1851312..1851321 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1851332 /Source="Nicolas_upshifts" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1851335..1851354 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1851350..1851568 /Source="Nicolas_S_feature" /locus_tag="new_2123802_2124020" /HighExp="S6, S8, S7, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="yojE" /AntisenseCor="-0.562105310907978" /AntisenseRegPval="-23.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S751" promotor_-10 complement(1851494..1851513) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1851514) /Source="Nicolas_upshifts" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1851525..1851532) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1851569..1852042 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17720779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17720779; Product type s: structure" /codon_start=1 /transl_table=11 /product="component of the spore coat" /protein_id="YP_054583.1" /db_xref="EnsemblGenomes-Gn:BSU19490" /db_xref="EnsemblGenomes-Tr:CAE01457" /db_xref="GOA:Q7WY67" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG14190" /db_xref="UniProtKB/Swiss-Prot:Q7WY67" /translation="MFEWNKYFPFHNQFSKEALKKADPKEVETYVNRVMESVFGSDYA AQFPFRDPLPQKEHPAKPDAKPDVKPDIDIFETADHVFVKVPISEEWLEQVRIKHTSH ELWLENLPRADHPKKVNLPCLVKRKGTKAVYKDGLLEVMFQKQQDYNMSEVEIIR*" /label="gerT CDS" gene 1851569..1852042 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /label="gerT gene" downshifts 1852039 /Source="Nicolas_upshifts" /id="D1074" /incds=0 /nref=23 /ntot=53 /MaxReadThrough="-0.0703700000000005" /MaxDrop="9.27889" /score="40.8456275" /energy="-16.6" /TU="NA" /idTUdmin="U1595" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1852077..1852313) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389832.1" /db_xref="EnsemblGenomes-Gn:BSU19510" /db_xref="EnsemblGenomes-Tr:CAB13842" /db_xref="GOA:O31861" /db_xref="SubtiList:BG13555" /db_xref="UniProtKB/Swiss-Prot:O31861" /translation="MYPHHSYLRGIPGPAGYPARSPFLFGAPLVGGLLGGFLGSALFN YSRPYAYPPGPYGYGGGPYGFGAGVPYGGYPGFY*" /label="yojB CDS" gene complement(1852077..1852313) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /label="yojB gene" downshifts complement(1852085) /Source="Nicolas_upshifts" /id="D1075" /incds=0 /nref=37 /ntot=68 /MaxReadThrough="2.10188" /MaxDrop="7.8003" /score="35.4403926" /energy="-16.6" /TU="NA" /idTUdmin="U1597" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1852336..1852355) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1852351) /Source="Nicolas_upshifts" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1852369..1852378) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1852398..1853732) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 3020045, 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/anion permease" /protein_id="NP_389833.1" /db_xref="EnsemblGenomes-Gn:BSU19520" /db_xref="EnsemblGenomes-Tr:CAB13843" /db_xref="GOA:O31862" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG13554" /db_xref="UniProtKB/Swiss-Prot:O31862" /translation="MPILIVAVGVLILLFLIIKVKLNTFVSLIVVSFLVAIGLGMDIN KIVLSIETGIGGQLGHLALVFGLGAMLGRLVSDAGGGYRIAITLIDKFGRKRIQAAVV VASFIIGIALFFEVGLVLLIPIVYAIAKELKMPFLYLGIPMAAALNVTHGFLPPHPAP TAISVAYGAHIGQVLLFGIIIAVPTTVIAGPLFNKFAMKRFPGAYQKHGNLSGLGPRK EFQLDETPGFAISAVTSLFPVIFMAMATIFSLLLSEHSKGKDIIEFIGTPGTAMLISL LLALYTMGYARKISMQEIGRSISESISQIAMMLLIIGGGGAFKQVLIDGGVGDYVADF FRQTNMSPLFVAWTIAAVLRLCLGSATVAALTTAGMAAPLMEAGSVNPALMVLATGAG SVIACHVNDAGFWMVKEFFGLSMKETFQTWTLLTTVLSVTGLGCVLLAGLVM*" /label="yojA CDS" gene complement(1852398..1853732) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /label="yojA gene" S_feature complement(1853733..1853868) /Source="Nicolas_S_feature" /locus_tag="new_2126185_2126320_c" /HighExp="M0t90, M40t90, Lbtran, S1, dia5, Mt0, T0.0H, BI, Lbstat, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25781100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S752" promotor_-10 complement(1853865..1853884) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1853875) /Source="Nicolas_upshifts" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1853899..1853906) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1853964..1853971 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1853986..1854005 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1853989 /Source="Nicolas_upshifts" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1853990..1854096 /Source="Nicolas_S_feature" /locus_tag="new_2126442_2126548" /HighExp="M0t90, M40t90, LoTm, Salt, Cold, BI, HPh, LBGstat, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S753" CDS 1854097..1854486 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /EC_number="5.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_389834.1" /db_xref="EnsemblGenomes-Gn:BSU19530" /db_xref="EnsemblGenomes-Tr:CAB13844" /db_xref="GOA:O34882" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG13530" /db_xref="UniProtKB/Swiss-Prot:O34882" /translation="MPLLRFDVIEGRDEKSLQLLLDTAHQAMVEAFGVPERDRYQIVH QHPANELIIQDAGLGFQRTKDMVIISMTSKARTESQKEKLYALLAERLEKKCEISPDD LMVSITENGDADWSFGLGEAQFLNGKL*" /label="yodA CDS" gene 1854097..1854486 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /label="yodA gene" downshifts 1854496 /Source="Nicolas_upshifts" /id="D1076" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.20831" /MaxDrop="2.65754" /score="14.4455719" /energy="-13.2" /TU="NA" /idTUdmin="U1599" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1854893..1855231) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17158660, 18208493, 20652907, 27531959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17158660, 18208493, 20652907, 27531959; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_389835.1" /db_xref="EnsemblGenomes-Gn:BSU19540" /db_xref="EnsemblGenomes-Tr:CAB13845" /db_xref="GOA:O34844" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:5HS7" /db_xref="PDB:5HS8" /db_xref="PDB:5HS9" /db_xref="SubtiList:BG13531" /db_xref="UniProtKB/Swiss-Prot:O34844" /translation="MGNTMCPKMESAFSLLGKRWNGLIIHVLMDGPKRFKEITETIPM ISQKMLAERLKELEQNEIVERQVLPETPVKVIYTLTEKGTALQAVFQEMQAWADQFCE PGDTVCEEEK*" /label="arxR CDS" gene complement(1854893..1855231) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /label="arxR gene" promotor_-35 1855254..1855261 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1855275..1855294 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1855284 /Source="Nicolas_upshifts" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="upshifts" S_feature 1855288..1855360 /Source="Nicolas_S_feature" /locus_tag="new_2127740_2127812" /HighExp="dia5, Diami, dia15, Salt, Lbtran, Heat, HiOs, S1, aero, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S754" promotor_-10 complement(1855319..1855338) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1855322) /Source="Nicolas_upshifts" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1855350..1855356) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1855361..1855969 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /EC_number="1.6.99.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 21749987, 24525333, 26312069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="water forming NADH oxidase (nitroreductase)" /protein_id="NP_389836.1" /db_xref="EnsemblGenomes-Gn:BSU19550" /db_xref="EnsemblGenomes-Tr:CAB13846" /db_xref="GOA:P81102" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG13532" /db_xref="UniProtKB/Swiss-Prot:P81102" /translation="MTNTLDVLKARASVKEYDTNAPISKEELTELLDLATKAPSAWNL QHWHFTVFHSDESKAELLPVAYNQKQIVESSAVVAILGDLKANENGEEVYAELASQGY ITDEIKQTLLGQINGAYQSEQFARDSAFLNASLAAMQLMIAAKAKGYDTCAIGGFNKE QFQKQFDISERYVPVMLISIGKAVKPAHQSNRLPLSKVSTWL*" /label="noxC CDS" gene 1855361..1855969 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /label="noxC gene" downshifts 1855959 /Source="Nicolas_upshifts" /id="D1077" /incds=0 /nref=98 /ntot=245 /MaxReadThrough="1.58009" /MaxDrop="5.56809" /score="28.8840715" /energy="-14.3" /TU="NA" /idTUdmin="U1600" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1856012..1856614) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389837.1" /db_xref="EnsemblGenomes-Gn:BSU19560" /db_xref="EnsemblGenomes-Tr:CAB13847" /db_xref="GOA:O34842" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13533" /db_xref="UniProtKB/Swiss-Prot:O34842" /translation="MKHIYEKGTSDNVLLLLHGTGGNEHDLLSLGRFIDPDAHLLGVR GSVLENGMPRFFKRLSEGVFDEKDLVVRTRELKDFIDEAAETHQFNRGRVIAVGYSNG ANIAASLLFHYKDVLKGAILHHPMVPIRGIELPDMAGLPVFIGAGKYDPLCTKEESEE LYRYLRDSGASASVYWQDGGHQLTQHEAEQAREWYKEAIV*" /label="yodD CDS" gene complement(1856012..1856614) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /label="yodD gene" CDS complement(1856630..1857541) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 17407181, 19329649, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-dependent lyase/dioxygenase" /protein_id="NP_389838.1" /db_xref="EnsemblGenomes-Gn:BSU19570" /db_xref="EnsemblGenomes-Tr:CAB13848" /db_xref="GOA:O34543" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13534" /db_xref="UniProtKB/Swiss-Prot:O34543" /translation="MKTEGLHHVTAFARDPQENLRFYTEVLGLRLVKKTVNFDDPGTY HFYFGNQNGDPGTIMTFFPFQGSGQGTVGKGQAGRVYFSVPSGSLSFWKERLEKSGLS LEEKTLFGEKGLIFDDTEDLPLAIMEDAKSGKSEWTPDGITTNEAITGMKGVLLYSYD PQATIQLLTESFGYTKVAEEDQIVRLASSAAVGGVIDVHLHPEKRGVGGYGTVHHVAF RTKKKEQAKWLPIIAENHLPSSEILDREYFTSVYFREKGGILFEIATDEPGFMTDETF AELGTSLKLPEWLEKHRQQITDILPEL*" /label="yodE CDS" gene complement(1856630..1857541) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /label="yodE gene" promotor_-10 complement(1857570..1857589) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1857586) /Source="Nicolas_upshifts" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1857605..1857610) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1857662..1857665 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1857680..1857699 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1857682 /Source="Nicolas_upshifts" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="upshifts" CDS 1857725..1857925 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016, 24843172; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="YP_003097742.1" /db_xref="EnsemblGenomes-Gn:BSU19579" /db_xref="EnsemblGenomes-Tr:CAX52639" /db_xref="GOA:C0H431" /db_xref="InterPro:IPR021741" /db_xref="UniProtKB/Swiss-Prot:C0H431" /translation="MVKKALIVILILLPFVQLALLPLVNRIEPIMFGLPFFHFWLLLW IIVTPLCSFGIYQMQKKDGGLE*" /label="yoyD CDS" gene 1857725..1857925 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /label="yoyD gene" CDS 1857925..1859415 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12823818, 15849754, 16850406, 24142252, 27766092; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite permease" /protein_id="NP_389839.1" /db_xref="EnsemblGenomes-Gn:BSU19580" /db_xref="EnsemblGenomes-Tr:CAB13849" /db_xref="GOA:O34745" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13535" /db_xref="UniProtKB/Swiss-Prot:O34745" /translation="MQGNLTALLITAIIVLTVVCIGFLAGRDKSSRTSVEEWSVGGRR FGGLLVWFLVGADLYTAYTFLGLTSTAFTGGSVAFFAIPYSVLAYFIAYFFLPKLWKV AKIHKLTTLADYARERFNSKLLASLVAIVGVLMLIPYICLQLSGIQDTLQVAGTGYIN VKFVVIISFILVALYTFFSGIKGPTYTAIIKDILVWVIMLFMVVSLPLIHFNGWTPMI DTLVKEAPQMLTIPSEGPKGIPWFITASIVSALALFMWAHAATGVFTAKSADAVRKNS MFLPLYNIVLILVIFLGFIAFLVLPEDTNPRLALLHLIQTSYGGVAQGFAYATIALAS LIPCSIMAIGASNLFANNLYRDLIHPNVSQSKLTLVTRSMVFVVIGLALLFGMLFPTA LVTLQLLGVSGMVQIFPAIAVSLFWKNQTKEATVIGLLAGLAVTFIVYITQSAHGIYE GFWGLAANMIAVVILNPLFVKNAGSNPVIEGLFGKKQDANPNQKGA*" /label="yodF CDS" gene 1857925..1859415 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /label="yodF gene" promotor_-10 complement(1858660..1858671) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1858664) /Source="Nicolas_upshifts" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1858685..1858691) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1859403 /Source="Nicolas_upshifts" /id="D1078" /incds=0 /nref=128 /ntot=189 /MaxReadThrough="1.75716" /MaxDrop="6.37839" /score="42.3111155" /energy="-14.6" /TU="NA" /idTUdmin="U1603" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1859450..1860850) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /EC_number="3.4.21.102" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8996100, 10974125, 14526016, 17114254, 19889088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxy-terminal processing protease (Prc homolog, tail specific protease)" /protein_id="NP_389840.1" /db_xref="EnsemblGenomes-Gn:BSU19590" /db_xref="EnsemblGenomes-Tr:CAB13850" /db_xref="GOA:O34666" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11794" /db_xref="UniProtKB/Swiss-Prot:O34666" /translation="MKRQLKLFFIVLITAVVASALTLFITGNSSILGQKSASTGDSKF DKLNKAYEQIKSDYYQKTDDDKLVDGAIKGMIQSLDDPYSTYMDQEQAKSFDETISAS FEGIGAQVEEKDGEILIVSPIKGSPAEKAGIKPRDQIIKVNGKSVKGMNVNEAVALIR GKKGTKVKLELNRAGVGNIDLSIKRDTIPVETVYSEMKDNNIGEIQITSFSETTAKEL TDAIDSLEKKGAKGYILDLRGNPGGLMEQAITMSNLFIDKGKNIMQVEYKNGSKEVMK AEKERKVTKPTVVLVNDGTASAAEIMAAALHESSNVPLIGETTFGKGTVQTAKEYDDG STVKLTVAKWLTADGEWIHKKGIKPQVKAELPDYAKLPYLDADKTYKSGDTGTNVKVA QKMLKALGYKVKVNSMYDQDFVSVVKQFQKKEKLNETGILTGDTTTKLMIELQKKLSD NDTQMEKAIETLKKEM*" /label="ctpA CDS" gene complement(1859450..1860850) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /label="ctpA gene" downshifts complement(1859474) /Source="Nicolas_upshifts" /id="D1079" /incds=0 /nref=188 /ntot=292 /MaxReadThrough="0.590400000000001" /MaxDrop="7.62713" /score="34.5981085" /energy="-14.6" /TU="NA" /idTUdmin="U1606" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-35 1860621..1860630 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1860642..1860657 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1860656 /Source="Nicolas_upshifts" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1860870..1860889) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1860890) /Source="Nicolas_upshifts" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1860903..1860910) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1860949..1860958 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1860964 /Source="Nicolas_upshifts" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1860971..1860990 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1861003..1861704 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19703276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_389841.1" /db_xref="EnsemblGenomes-Gn:BSU19600" /db_xref="EnsemblGenomes-Tr:CAB13851" /db_xref="GOA:O34954" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13536" /db_xref="UniProtKB/Swiss-Prot:O34954" /translation="MSRYLEMLSLFGVAGAHPGGLAFSKAVLQKAAPSPDQPILDAGC GTGQTAAYLGHLLYPVTVVDKDPIMLEKAKKRFANEGLAIPAYQAELEHLPFSSESFS CVLSESVLSFSRLTSSLQEISRVLKPSGMLIGIEAALKKPMPPAEKKQMMDFYGFTCL HEESEWHKLLRSYGFQKTEAMSLLPEDMEFEPTTEMDLSQTIDPIYYDTLQTHYQLMQ LYSEYMGHCIFIAYK*" /label="yodH CDS" gene 1861003..1861704 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /label="yodH gene" promotor_-35 1861729..1861737 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1861751..1861770 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1861756 /Source="Nicolas_upshifts" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="upshifts" CDS 1861792..1862043 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546, 23155385; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389842.1" /db_xref="EnsemblGenomes-Gn:BSU19610" /db_xref="EnsemblGenomes-Tr:CAB13852" /db_xref="GOA:O34654" /db_xref="SubtiList:BG13537" /db_xref="UniProtKB/Swiss-Prot:O34654" /translation="MERYYHLCKNHQGKVVRITERGGRVHVGRITRVTRDRVFIAPVG GGPRGFGYGYWGGYWGYGAAYGISLGLIAGVALAGLFFW*" /label="yodI CDS" gene 1861792..1862043 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /label="yodI gene" downshifts 1862064 /Source="Nicolas_upshifts" /id="D1080" /incds=0 /nref=49 /ntot=83 /MaxReadThrough="0.88268" /MaxDrop="7.18785" /score="13.9812819" /energy="-15.5" /TU="NA" /idTUdmin="U1607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1862114..1862935) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /EC_number="3.4.16.4" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8631706, 15187182, 24909784" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8631706, 15187182, 24909784; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase lipoprotein (D-ala releasing from tetrapeptide hydrolysis)" /protein_id="NP_389843.1" /db_xref="EnsemblGenomes-Gn:BSU19620" /db_xref="EnsemblGenomes-Tr:CAB13853" /db_xref="GOA:O34866" /db_xref="InterPro:IPR003709" /db_xref="InterPro:IPR009045" /db_xref="PDB:4OX3" /db_xref="SubtiList:BG13538" /db_xref="UniProtKB/Swiss-Prot:O34866" /translation="MKKSGKWFSLAAALSVTAIVGAGCSMSNGDAQKDTKTTAETKQT EQKTADSKKSNTQNSEFSLESQYFNDIKKVDGLETIQNPENILALVNKQYALPGNYEP SDLVIPDVEFSFEEKIQKRYIRKEAADALKTMFDAAKKEGYELAAVSGYRSYDRQKVI FDNEVSLKGERKAKEAVAYPGESEHQTGLAMDISSRSNGFELNEAFGSTADGKWVQDN AYKYGFIIRYPKNKEDITKYEYEPWHLRYVGKKAAKVIQDNDLTLEEYFEKVKKI*" /label="ldcB CDS" gene complement(1862114..1862935) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /label="ldcB gene" downshifts complement(1862140) /Source="Nicolas_upshifts" /id="D1081" /incds=0 /nref=180 /ntot=242 /MaxReadThrough="0.784690000000001" /MaxDrop="5.88637" /score="-9.13236272" /energy="-6.1" /TU="NA" /idTUdmin="U1609" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1862936..1863017) /Source="Nicolas_S_feature" /locus_tag="new_2135388_2135469_c" /HighExp="dia15, LBGexp, G180, LBGtran, dia0, H2O2, Oxctl, Lbexp, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S755" CDS complement(1863018..1863719) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12571059, 16511068, 21279421, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12571059, 16511068, 21279421, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_389844.1" /db_xref="EnsemblGenomes-Gn:BSU19630" /db_xref="EnsemblGenomes-Tr:CAB13854" /db_xref="GOA:O34925" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR004402" /db_xref="InterPro:IPR018016" /db_xref="InterPro:IPR035994" /db_xref="PDB:4D8V" /db_xref="PDB:4D8X" /db_xref="PDB:4D8Y" /db_xref="PDB:4D98" /db_xref="PDB:4D9H" /db_xref="PDB:4DA0" /db_xref="PDB:4DA6" /db_xref="PDB:4DA7" /db_xref="PDB:4DA8" /db_xref="PDB:4DAB" /db_xref="PDB:4DAE" /db_xref="PDB:4DAN" /db_xref="PDB:4DAO" /db_xref="PDB:4DAR" /db_xref="SubtiList:BG12581" /db_xref="UniProtKB/Swiss-Prot:O34925" /translation="MSVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRG MYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRD VILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFY NDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQT TFHDMIEVALHSVSQ*" /label="deoD CDS" gene complement(1863018..1863719) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /label="deoD gene" S_feature complement(1863720..1863809) /Source="Nicolas_S_feature" /locus_tag="new_2136172_2136261_c" /HighExp="dia15, G180, dia5, LBGtran, dia0, LBGexp, Lbexp, G150, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S756" promotor_-10 complement(1863794..1863813) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1863809) /Source="Nicolas_upshifts" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1863829..1863833) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1863867..1863873 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1863888..1863899 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1863905 /Source="Nicolas_upshifts" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="upshifts" CDS 1863921..1864046 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24079885" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097743.1" /db_xref="EnsemblGenomes-Gn:BSU19639" /db_xref="EnsemblGenomes-Tr:CAX52640" /db_xref="UniProtKB/Swiss-Prot:C0H432" /translation="MGKKHRNRITGQKKNNHIPEKDIIAAEEAHGKEYSAAKRKP*" /label="yoyE CDS" gene 1863921..1864046 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /label="yoyE gene" downshifts 1864044 /Source="Nicolas_upshifts" /id="D1082" /incds=0 /nref=9 /ntot=26 /MaxReadThrough="0.67198" /MaxDrop="4.89617" /score="16.4028635" /energy="-8.5" /TU="NA" /idTUdmin="U1610" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1864086..1864400) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24079885, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24079885, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="shape determination factor" /protein_id="NP_389845.2" /db_xref="EnsemblGenomes-Gn:BSU19640" /db_xref="EnsemblGenomes-Tr:CAB13855" /db_xref="InterPro:IPR025923" /db_xref="SubtiList:BG13539" /db_xref="UniProtKB/Swiss-Prot:O30472" /translation="MMLSVFKKKSCSYDVTIFQTPRFGEKKGYRAVYRTELNGSDHQD VLKRAFSLFNVFDTVPSDYDARFMATGDVILIDEGRKGKTYYQLLPAGWRKINRLIVQ TT*" /label="yodL CDS" gene complement(1864086..1864400) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /label="yodL gene" downshifts complement(1864098) /Source="Nicolas_upshifts" /id="D1083" /incds=0 /nref=96 /ntot=232 /MaxReadThrough="1.74792" /MaxDrop="5.79235" /score="-0.334745097" /energy="-8.5" /TU="NA" /idTUdmin="U1611" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1864421..1864439) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1864428) /Source="Nicolas_upshifts" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1864450..1864458) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1864461..1865072) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /EC_number="3.1.3.27" /EC_number="3.1.3.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27528508, 28168443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27528508, 28168443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol phosphate (PGP) phosphatase; undecaprenyl-pyrophosphate phosphatase (promiscuous activity)" /protein_id="NP_389846.1" /db_xref="EnsemblGenomes-Gn:BSU19650" /db_xref="EnsemblGenomes-Tr:CAB13856" /db_xref="GOA:O34349" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR036938" /db_xref="PDB:5JKI" /db_xref="SubtiList:BG13540" /db_xref="UniProtKB/Swiss-Prot:O34349" /translation="MYKPVSLFLFFLILAAAIHTNAVQSADEAISKAAVLIRQPWLNE VMTGITHLGASSFLLPLIVIIGAGMFFYRKTWDGLLMLLVFGTDRLLNKVLKEWIERV RPDFAPLVHESSFSFPSGHSMNAACVYPVIAYFLVKHLPFLSKHKKMVYIIAGVIAVL VGISRVYLGVHFVTDVLGGFSLGLLLFFLVKGFDEKIKRFRQK*" /label="pgpB CDS" gene complement(1864461..1865072) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /label="pgpB gene" CDS complement(1865150..1865326) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389847.1" /db_xref="EnsemblGenomes-Gn:BSU19660" /db_xref="EnsemblGenomes-Tr:CAB13857" /db_xref="InterPro:IPR025545" /db_xref="SubtiList:BG13751" /db_xref="UniProtKB/Swiss-Prot:O31863" /translation="MKEIDLVIDTEEIAEFFYRELARRGYIPSEDELFEIADITFDYL IEKCMIDEELDEDE*" /label="yozD CDS" gene complement(1865150..1865326) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /label="yozD gene" downshifts complement(1865154) /Source="Nicolas_upshifts" /id="D1084" /incds=0 /nref=35 /ntot=48 /MaxReadThrough="3.33111" /MaxDrop="5.99901" /score="19.8458751" /energy="-11.9" /TU="U1612,U1613" /idTUdmin="U1615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1865165) /Source="Nicolas_upshifts" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1865169..1865188) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1865204..1865207) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1865340..1865358) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-10" upshifts complement(1865361) /Source="Nicolas_upshifts" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="upshifts" S_feature complement(1865363..1865584) /Source="Nicolas_S_feature" /locus_tag="new_2137815_2138036_c" /HighExp="S8, S7, S6, BT, B36, Pyr, G/S, H2O2, S5, G135" /AntisenseName="yoyF" /AntisenseCor="0.43167183745996701" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S757" promotor_-35 complement(1865374..1865379) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-35" promotor_-35 1865384..1865389 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1865404..1865422 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1865406 /Source="Nicolas_upshifts" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="upshifts" CDS 1865445..1865588 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097744.1" /db_xref="EnsemblGenomes-Gn:BSU19669" /db_xref="EnsemblGenomes-Tr:CAX52641" /db_xref="GOA:C0H433" /db_xref="UniProtKB/Swiss-Prot:C0H433" /translation="MIAKMMEALDGERFDIIMEKTLKGMTRVMIWGCLPYFLYVLIRM FTN*" /label="yoyF CDS" gene 1865445..1865588 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /label="yoyF gene" CDS complement(1865585..1866265) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389848.1" /db_xref="EnsemblGenomes-Gn:BSU19670" /db_xref="EnsemblGenomes-Tr:CAB13858" /db_xref="SubtiList:BG13541" /db_xref="UniProtKB/Swiss-Prot:O34414" /translation="MKQNKPKFQVGDIVVVIMYGTVGTITKVHQIDKHYLYEVNHNEV LYFESSIQLYKDYEGVIVDMEKLDIEYEFLIGDVVYVKDYGKELFRIIGHRTEIWRYL EDGWEDIIYELTRLKDGEWLETEEEDLTLVLRKYEMDQFVHQLLFVHYVGETGHEIGE DIASSALLQFEGGDEDQDTLHILAVSIVDELLDIYNDYKILYEMFQDEEYKDMMMFVL ESLKEHFS*" /label="yodN CDS" gene complement(1865585..1866265) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /label="yodN gene" S_feature 1865589..1866600 /Source="Nicolas_S_feature" /locus_tag="new_2138041_2139052" /HighExp="LoTm, S3, S8, S7, S4, T5.0H, BT, T4.0H, Pyr, S6" /AntisenseName="yodN" /AntisenseCor="0.52628108909126403" /AntisenseRegPval="-19.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S758" promotor_-10 complement(1866292..1866311) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1866298) /Source="Nicolas_upshifts" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1866325..1866334) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1866416..1866640) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389849.1" /db_xref="EnsemblGenomes-Gn:BSU19680" /db_xref="EnsemblGenomes-Tr:CAB13859" /db_xref="InterPro:IPR010673" /db_xref="InterPro:IPR023089" /db_xref="InterPro:IPR036806" /db_xref="PDB:2FJ6" /db_xref="SubtiList:BG13752" /db_xref="UniProtKB/Swiss-Prot:O31864" /translation="MKSFYHYLLKYRHPKPKDSISEFANQAYEDHSFPKTSTDYHEIS SYLELNADYLHTMATFDEAWDQYESEVHGR*" /label="yozE CDS" gene complement(1866416..1866640) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /label="yozE gene" downshifts complement(1866430) /Source="Nicolas_upshifts" /id="D1085" /incds=0 /nref=115 /ntot=243 /MaxReadThrough="1.81033" /MaxDrop="7.07662" /score="34.0666929" /energy="-10.8" /TU="NA" /idTUdmin="U1616" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1866681..1866700) /Source="Nicolas_upshift_promotors" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1866693) /Source="Nicolas_upshifts" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1866727..1867005) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344, 24914178" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097745.1" /db_xref="EnsemblGenomes-Gn:BSU19689" /db_xref="EnsemblGenomes-Tr:CAX52642" /db_xref="InterPro:IPR022451" /db_xref="InterPro:IPR022453" /db_xref="UniProtKB/Swiss-Prot:C0H434" /translation="MKTCEWCGELEAVPGRNTVYWELPDGTRAIELTDTPAMVCSSCG MTYQEENTVKEIEDQLLLIQTKKLPESLTYQQLMETERILKRNYFDFS*" /label="yokU CDS" gene complement(1866727..1867005) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /label="yokU gene" CDS complement(1867002..1868417) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /EC_number="5.4.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10629195, 10839984, 11148055, 17254853, 18307109, 21538109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629195, 10839984, 11148055, 17254853, 18307109, 21538109; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="lysine 2,3-aminomutase" /protein_id="NP_389850.1" /db_xref="EnsemblGenomes-Gn:BSU19690" /db_xref="EnsemblGenomes-Tr:CAB13860" /db_xref="GOA:O34676" /db_xref="InterPro:IPR003739" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022459" /db_xref="InterPro:IPR025895" /db_xref="SubtiList:BG13542" /db_xref="UniProtKB/Swiss-Prot:O34676" /translation="MKNKWYKPKRHWKEIELWKDVPEEKWNDWLWQLTHTVRTLDDLK KVINLTEDEEEGVRISTKTIPLNITPYYASLMDPDNPRCPVRMQSVPLSEEMHKTKYD LEDPLHEDEDSPVPGLTHRYPDRVLFLVTNQCSMYCRYCTRRRFSGQIGMGVPKKQLD AAIAYIRETPEIRDCLISGGDGLLINDQILEYILKELRSIPHLEVIRIGTRAPVVFPQ RITDHLCEILKKYHPVWLNTHFNTSIEMTEESVEACEKLVNAGVPVGNQAVVLAGIND SVPIMKKLMHDLVKIRVRPYYIYQCDLSEGIGHFRAPVSKGLEIIEGLRGHTSGYAVP TFVVDAPGGGGKIALQPNYVLSQSPDKVILRNFEGVITSYPEPENYIPNQADAYFESV FPETADKKEPIGLSAIFADKEVSFTPENVDRIKRREAYIANPEHETLKDRREKRDQLK EKKFLAQQKKQKETECGGDSS*" /label="kamA CDS" gene complement(1867002..1868417) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /label="kamA gene" promotor_-35 1867673..1867676 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1867692..1867711 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1867697 /Source="Nicolas_upshifts" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1868446..1869273) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21538109, 24914178" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epsilon-amino-beta-lysine acetyl transferase" /protein_id="NP_389851.1" /db_xref="EnsemblGenomes-Gn:BSU19700" /db_xref="EnsemblGenomes-Tr:CAB13861" /db_xref="GOA:O34895" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022525" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13543" /db_xref="UniProtKB/Swiss-Prot:O34895" /translation="MLKSIKSSGVTAVLDHDGFNKRIRVVRYDGAIEKALPDIVAAAK EENAEKIIVYAKQHDEPILAKQLFAPEGYLKGYYLGHSACVMVRYLSESRRQTDSYTE EQEIIEAIYRTAPRLRNDSTPVFTMRKAETNDMYQLSMLYKKVFRTYPTPVFDPAYIE KTMNANTVYYIMLDHDRLISAASAEINPELGHAEITDCAVLPEYRGHSLTSFLIEALE KEMAGEDIVHVFSLARASSFGMNAVLYHSGYQYGGRLINNCFIAEGLENMNIWCKQL* " /label="kamB CDS" gene complement(1868446..1869273) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /label="kamB gene" CDS complement(1869251..1870561) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /EC_number="3.5.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative deacetylase" /protein_id="NP_389852.1" /db_xref="EnsemblGenomes-Gn:BSU19710" /db_xref="EnsemblGenomes-Tr:CAB13862" /db_xref="GOA:O34984" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR033687" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12569" /db_xref="UniProtKB/Swiss-Prot:O34984" /translation="MRMQDIERKVIEWLDQHSAKAIRLLKRLIGEKSTLGSEFNAQAV VLEKLRQFHMDIDVWEPSIKQLKQHPYFKSNRSDFHESPNIVAKKTGAGGGRSLILNG HIDVVPEGSVKDWKYEPYQAVEENGKIYGRGSTDMKGGNTALLFALEALHACDVKLKG DVLFQSVVDEECGGAGTLSAIMRGYRADGALIPEPTNMKLFIKQQGSMWFRITVKGLS AHGGTRYEGVSAIEKSMHVITAIQELEKVRNARISDPLYDNIPIPVPVNIGTISGGAW PSSVADRVVIEGRCGIAPHEKPEAVKLELENWLKDLEYHDEWFKRHPVQVEWFGAQWL PNDLPDDHPLISVLQSAYQKMKQTEPIIEASPWGTDGGLLYHAGDTPVIVFGPGETKT AHQANEYIEVEAMIESAKIIALFVMDWCGLHTDGEDADAQVNKE*" /label="yodQ CDS" gene complement(1869251..1870561) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /label="yodQ gene" CDS complement(1870570..1871223) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyloate-acetoacetate CoA-transferase" /protein_id="NP_389853.1" /db_xref="EnsemblGenomes-Gn:BSU19720" /db_xref="EnsemblGenomes-Tr:CAB13863" /db_xref="GOA:O34466" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="SubtiList:BG13544" /db_xref="UniProtKB/Swiss-Prot:O34466" /translation="MGLGVAEREQIAKRAATEIKQGMIVNLGIGIPSLVPNFLKPDMQ VMFQAENGVLGIGESPEKGEEDAHLCNAAGYPVRAVKGASYFDTTMSFAMIRKGKIDI TILGALQVSQSGDLANWLVPGKKVPGMGGAMELAQKAKKVVVVMSHTDQKGRPKLTER CTLPLTAAGCVDLIITEKAVLEVDSHHFILKELMNGSTIDEVTRLTEAEIKIDMPFS* " /label="yodR CDS" gene complement(1870570..1871223) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /label="yodR gene" CDS complement(1871208..1871897) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxoacid CoA-transferase" /protein_id="NP_389854.1" /db_xref="EnsemblGenomes-Gn:BSU19730" /db_xref="EnsemblGenomes-Tr:CAB13864" /db_xref="GOA:O34317" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="SubtiList:BG13545" /db_xref="UniProtKB/Swiss-Prot:O34317" /translation="MAPFQKAISIDTAIADVRDGSVLMFGGFGGVGSPPSLIEAILDS GVTDLTVICNDAGFPDIGIGPLIVNQRVKTLIASHIGSNPVAGKQMTEGTLEVQFSPQ GTLAERIRAGGAGLGGILTDVGIDNQMVCEKKDIVTVAGKRYLIEEALTADFAFINAY IADEFGNLTYDKTARNMNPLMAMAARRTFAEAERIVPMGEISEEMIVTPGVFVEGVVR SEGVKWKWAWE*" /label="yodS CDS" gene complement(1871208..1871897) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /label="yodS gene" CDS complement(1871904..1873238) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /EC_number="2.6.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10839984, 15150230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminovalerate aminotransferase" /protein_id="NP_389855.1" /db_xref="EnsemblGenomes-Gn:BSU19740" /db_xref="EnsemblGenomes-Tr:CAB13865" /db_xref="GOA:O34662" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13546" /db_xref="UniProtKB/Swiss-Prot:O34662" /translation="MSSYLIKPELSSAYPVVSYAKGSYVYDQTGKKYLDGSSGAVTCN IGHGVRDVTEKLKEQLDQVSFAYRSQFTSEPAEQLAALLAQELPGDVNWSFFVNSGSE AIETAMKIAIQYWQEKKQTQKSIFLSRWSSYHGITLGALSLSGFYERRYRFTHLIERY PAISAPHIYRLNHETEEDFVQTAADELDTMIKRIGSQFIAGFVAEPIIGAAGAAITPP PGYYERLSEVCRTHDVLFIADEVMTGLGRTGRMLATEHWDTVPDIAVLGKGLGAGYAP IAAAVVSDSIIETIKQGSGVIMSGHTYSAHPYSAKAALEVLRYVLKHGLIKQSEKKGA VLKKKLDEAASQSGIIGEVRGKGLLLGIEFVADQKTKKVFPPEQAITQLIVSEAKKRG LIVYPSKAGIDSGEGDAVIIAPPFTISDGEMEELISIFSETVAAVEKNLKKD*" /label="yodT CDS" gene complement(1871904..1873238) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /label="yodT gene" CDS complement(1873219..1873374) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513966.1" /translation="MLDAEISKEPSLLGRLFLCEKVFAGNVMPPFGHSYNMVKGVLRW EHEQLFD*" /label="conserved hypothetical protein CDS" gene complement(1873219..1873374) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /label="gene" promotor_-10 complement(1873257..1873275) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1873273) /Source="Nicolas_upshifts" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1873291..1873296) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1873368..1873601) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a type I toxin family (sporulation operon)" /protein_id="YP_003097746.2" /db_xref="EnsemblGenomes-Gn:BSU19749" /db_xref="EnsemblGenomes-Tr:CAX52643" /db_xref="GOA:C0H435" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H435" /translation="MSGCILYFIISLHEIGVCTNHLGLGPHKMSYIVIRKDENSMYGY SGYGYGFGCGTNTFVLIVVLFILLIIVGAAFIC*" /label="yoyG CDS" gene complement(1873368..1873601) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /label="yoyG gene" downshifts complement(1873375) /Source="Nicolas_upshifts" /id="D1086" /incds=0 /nref=96 /ntot=237 /MaxReadThrough="2.70127" /MaxDrop="7.98506" /score="25.3834194" /energy="-16.5" /TU="NA" /idTUdmin="U1620" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 1873477..1873481 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1873490..1873504 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1873505 /Source="Nicolas_upshifts" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1873506..1873525) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1873515) /Source="Nicolas_upshifts" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1873540..1873549) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1873561..1874340) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 7592393, 10066829, 27260256" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 7592393, 10066829, 27260256; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389856.1" /db_xref="EnsemblGenomes-Gn:BSU19750" /db_xref="EnsemblGenomes-Tr:CAB13866" /db_xref="GOA:P42093" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11197" /db_xref="UniProtKB/Swiss-Prot:P42093" /translation="MTGHYSKTEHQYILLTSESASFDHYSVYRDPQLPQIFSHNFVQL HDTFPLERLLNFLPSVPKLLDANYLHLKASPQHVFPLGLKQSLVKSGFVVEDELLYDM KLSDWKGQMGHPLTAWGTAKSLSDGSSIMKIYDSIYIGEAIAEQKLKRKYPFYEADII ILVVCYSDQAQKVPIGCGELFIDHQEKTAKIEEVAILDQFQRKGYGSILVKEMLSIAK SLGMEAAYLVAASTDGATQFYEKLTFKKYERVHTVFHYFLT*" /label="cgeE CDS" gene complement(1873561..1874340) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /label="cgeE gene" CDS complement(1874369..1875649) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in maturation of the outermost layer of the spore" /protein_id="NP_389857.1" /db_xref="EnsemblGenomes-Gn:BSU19760" /db_xref="EnsemblGenomes-Tr:CAB13867" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11196" /db_xref="UniProtKB/Swiss-Prot:P42092" /translation="MGEKVSIILTSYNKPDYLQKAIESVIQQTHDLWELFIMDDHSNA ETTAVIHKYLHDRRIQYHNSFVHPADRLKTARYATLINSALPFADGDYISYLTDDTVY HPERLSRMVQEFSHKPEAQAVYSKQKVVHVNERGEEISHFYRNANAVLDQAAFQVDHC SVMHRRSLLNLIHHKFGGYWDDDMKHWNHGDAIFWARLNNFTPFLPINEVLDTTYKTP DSFQNAYRFLPADLIDGSFVKGSDQNVYFFDQGVRHPVGEKWGFLYLNRTVAVPDPYL FQYRIGKILNIPNYILVKEADHPAIFYIEAGKKRRIVDQYAFQFYQFQRKDIVTIGKE EMETLPEGPPITWKRSELIKNPPGRRLFFIEREPFLFLNGVFHPISEQVTRKFFLHQK PISASFRNIQQFPIGKPFYPVYDEIIKKLNIATE*" /label="cgeD CDS" gene complement(1874369..1875649) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /label="cgeD gene" promotor_-10 complement(1875017..1875035) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1875033) /Source="Nicolas_upshifts" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1875049..1875056) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1875617..1875635) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1875627) /Source="Nicolas_upshifts" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1875651..1875656) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1875714..1876019) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389858.1" /db_xref="EnsemblGenomes-Gn:BSU19770" /db_xref="EnsemblGenomes-Tr:CAB13868" /db_xref="SubtiList:BG11195" /db_xref="UniProtKB/Swiss-Prot:P42091" /translation="MDLEKQVDREENQDDLHFILLLLILLIRQSSSEGNPSDLRRQLV FAKELGVPVSKVNLINGDTLQNVIVKEVLTDLVIFQNPLNNTRSHVSLSSVVSWGAF* " /label="cgeC CDS" gene complement(1875714..1876019) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /label="cgeC gene" downshifts complement(1875847) /Source="Nicolas_upshifts" /id="D1087" /incds=1 /nref=2 /ntot=28 /MaxReadThrough="5.32389" /MaxDrop="2.61092" /score="23.1569137" /energy="-13.4" /TU="U1623" /idTUdmin="U1623" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1876043..1876062) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-10" upshifts complement(1876058) /Source="Nicolas_upshifts" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="upshifts" promotor_-35 complement(1876076..1876085) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-35" promotor_-35 1876155..1876164 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1876178..1876197 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1876178 /Source="Nicolas_upshifts" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1876199) /Source="Nicolas_upshifts" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1876201..1876215) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1876224..1876228) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1876224..1876625 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:759239, 14702409, 15621419, 19933362, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 759239, 14702409, 15621419, 19933362, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outermost layer component" /protein_id="NP_389859.1" /db_xref="EnsemblGenomes-Gn:BSU19780" /db_xref="EnsemblGenomes-Tr:CAB13869" /db_xref="SubtiList:BG11193" /db_xref="UniProtKB/Swiss-Prot:P42089" /translation="MSSENAQLKKDLIKAVLSPLFPTATEGGENMDSNLKALLDAAID QKVDESETVTAESILDPSLPARWIFARITPGTTISIVTDSGDMIGPVVFVAFDQVHGI VFVTQESSVTPAGQATTLIDVDKVESVTFFS*" /label="cgeA CDS" gene 1876224..1876625 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /label="cgeA gene" CDS 1876632..1877585 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389860.2" /db_xref="EnsemblGenomes-Gn:BSU19790" /db_xref="EnsemblGenomes-Tr:CAB13870" /db_xref="InterPro:IPR024542" /db_xref="SubtiList:BG11194" /db_xref="UniProtKB/Swiss-Prot:P42090" /translation="MKVLYIQSGYGGIYSYFDRWAEECFQNTHTEYMIADKPEAESLM KIEAFQPDFTLMMVGDRVPHDWLTWLKGKDIPVYVWLTEDPFYMDISLQVIKLADAIL TIEQNAALYYQELGYQNVYYVPIPVNHRLFKKMGTEHSYHSNLLIIGYPYPNRVQLMK EAVHLPFTVRVIGKEWGKYLPKKVLKQPHIDVVSTWVPPEQAVHYYNGADIVINAHRP YHFAFNQNTMRIKNASFNNRTFDIAACEAFQLTDLPAAHPFSSIISYHGMNDFKEKAA FYINHPEERQKAAAANYKETVPAFTFDELPAKLKAIHLALS*" /label="cgeB CDS" gene 1876632..1877585 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /label="cgeB gene" downshifts 1877575 /Source="Nicolas_upshifts" /id="D1088" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="2.94229" /MaxDrop="5.87549" /score="22.1420541" /energy="-9" /TU="NA" /idTUdmin="U1624" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1877656..1878804) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /EC_number="3.1.3.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phytase" /protein_id="NP_389861.1" /db_xref="EnsemblGenomes-Gn:BSU19800" /db_xref="EnsemblGenomes-Tr:CAB13871" /db_xref="GOA:P42094" /db_xref="InterPro:IPR003431" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11198" /db_xref="UniProtKB/Swiss-Prot:P42094" /translation="MKVPKTMLLSTAAGLLLSLTATSVSAHYVNEEHHFKVTAHTETD PVASGDDAADDPAIWVHEKHPEKSKLITTNKKSGLVVYDLDGKQLHSYEFGKLNNVDL RYDFPLNGEKIDIAAASNRSEGKNTIEVYAIDGDKGKLKSITDPNHPISTNISEVYGF SLYHSQKTGAFYALVTGKQGEFEQYEIVDGGKGYVTGKKVREFKLNSQTEGLVADDEY GNLYIAEEDEAIWKFNAEPGGGSKGQVVDRATGDHLTADIEGLTIYYAPNGKGYLMAS SQGNNSYAMYERQGKNRYVANFEITDGEKIDGTSDTDGIDVLGFGLGPKYPYGIFVAQ DGENIDNGQAVNQNFKIVSWEQIAQHLGEMPDLHKQVNPRKLKDRSDG*" /label="phyC CDS" gene complement(1877656..1878804) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /label="phyC gene" downshifts complement(1877673) /Source="Nicolas_upshifts" /id="D1089" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="2.64059" /MaxDrop="5.59857" /score="17.7154517" /energy="-8.7" /TU="NA" /idTUdmin="U1629" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" promotor_-35 1878817..1878821 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1878830..1878849) /Source="Nicolas_upshift_promotors" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1878837..1878856 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1878839) /Source="Nicolas_upshifts" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 1878847 /Source="Nicolas_upshifts" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1879108..1879116 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1879130..1879149 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1879133 /Source="Nicolas_upshifts" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="upshifts" CDS 1879174..1880199 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014664318.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="polysaccharide biosynthesis protein" /protein_id="WP_003230816.1" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /translation="MPKQQTAELKPFFHNKTVLVTGGTGSIGSQIVKRLLMLTPKQVI VFSKDDSKQYVMSQKYAEDKRLLFVLGDVRDHRRVNQVMKGVDIVFHAAALKQVPTCE DHPFEAIQTNLIGGQNVVEAALSHRVQHVINISTDKAVSPVNTMGATKLLSEKLFHQA NRHVQNKGTLFCSVRFGNVLGSRGSVIPILFEQMMEGEPLTITDKNMTRFFMSIDDAA TLTLQSAAITKGGETFIFKMESLKLEELIHGFEEYASQHGLPRPAAVEVGKRPGEKLH EELTSPHEIESLYEWGNLYAILPEPEKHPDFRKVNLPGYQSDQAPLITKERIAQIIEE LHQEKKA*" /label="Delta6_BSU_19810-BSU_21670" gene 1879174..1880199 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /label="Delta6_BSU_19810-BSU_21670" downshifts 1879577 /Source="Nicolas_upshifts" /id="D1090" /incds=0 /nref=18 /ntot=39 /MaxReadThrough="0.75679" /MaxDrop="7.79081" /score="-6.65536786" /energy="-8.7" /TU="NA" /idTUdmin="U1628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 <1879579..1879583 /Source="Nicolas_upshift_promotors" /id="U1702" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1418 /SigmaFactorBS="tttcatttttgacctcacagccactaATAGTTTCCActaaga aaagtagTAAGTATCTTAAAAAACAGAtaaagctgtatctcctgtgaacacaatgggt g" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" SCAR 1879593..1879594 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta_SP_beta" downshifts 1880191 /Source="Nicolas_upshifts" /id="D1134" /incds=0 /nref=22 /ntot=177 /MaxReadThrough="2.90949" /MaxDrop="5.54327" /score="-2.31796312" /energy="-13.5" /TU="NA" /idTUdmin="U1701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1880243..1880674) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /EC_number="1.8.4.12" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15680230, 16803968, 17031545, 18239417, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine R-sulfoxide reductase" /protein_id="NP_390051.1" /db_xref="EnsemblGenomes-Gn:BSU21680" /db_xref="EnsemblGenomes-Tr:CAB14086" /db_xref="GOA:P54155" /db_xref="InterPro:IPR002579" /db_xref="InterPro:IPR011057" /db_xref="InterPro:IPR028427" /db_xref="PDB:2KZN" /db_xref="PDB:3E0O" /db_xref="SubtiList:BG11628" /db_xref="UniProtKB/Swiss-Prot:P54155" /translation="MAYNKEEKIKSLNRMQYEVTQNNGTEPPFQNEYWDHKEEGLYVD IVSGKPLFTSKDKFDSQCGWPSFTKPIEEEVEEKLDTSHGMIRTEVRSRTADSHLGHV FNDGPGPNGLRYCINSAALRFVPKHKLKEEGYESYLHLFNK*" /label="msrB CDS" gene complement(1880243..1880674) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /label="msrB gene" downshifts complement(1880248) /Source="Nicolas_upshifts" /id="D1135" /incds=0 /nref=229 /ntot=262 /MaxReadThrough="2.46559" /MaxDrop="6.77483" /score="1.42817565" /energy="-12.3" /TU="NA" /idTUdmin="U1704" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1880675..1881208) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /EC_number="1.8.4.11" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9573155, 16803968, 17062561, 18662407" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573155, 16803968, 17062561, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine S-sulfoxide reductase" /protein_id="NP_390052.1" /db_xref="EnsemblGenomes-Gn:BSU21690" /db_xref="EnsemblGenomes-Tr:CAB14087" /db_xref="GOA:P54154" /db_xref="InterPro:IPR002569" /db_xref="InterPro:IPR036509" /db_xref="SubtiList:BG11627" /db_xref="UniProtKB/Swiss-Prot:P54154" /translation="MSEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPT YEEVCSETTGHREAVQITFHPDVFPYEKLLELFWQQIDPTDAGGQFADRGSSYRAAIF YHNDKQKELAEASKQRLAESGIFKDPIVTDILKAEPFYEAEGYHQHFYKKNPAHYQRY RTGSGRAGFISEHWGAK*" /label="msrA CDS" gene complement(1880675..1881208) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /label="msrA gene" promotor_-35 1881212..1881218 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1881229..1881339 /Source="Nicolas_S_feature" /locus_tag="new_2288083_2288193" /HighExp="B60, Lbstat, Cold, M9-stat, T4.0H, LoTm, S0, T3.30H, BC, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S817" upshifts 1881229 /Source="Nicolas_upshifts" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1881231..1881250 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1881236..1881255) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1881256) /Source="Nicolas_upshifts" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1881271..1881272) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1881340..1881765 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9571784, 10809700; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_390053.1" /db_xref="EnsemblGenomes-Gn:BSU21700" /db_xref="EnsemblGenomes-Tr:CAB14088" /db_xref="GOA:P54182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11626" /db_xref="UniProtKB/Swiss-Prot:P54182" /translation="MKVRTQMMYDMETLLRKVFKQIRNEINEILDKELSRNEFTILRI LSEQGPKKVTEFAPILEVSASHITAVTDALVEKEWITRIRSKEDRRIIRIHITEAGEK VLQHFNEKKTEYFFKRFDCYTDAELATLIELFSKLDKKR*" /label="ypoP CDS" gene 1881340..1881765 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /label="ypoP gene" downshifts 1881753 /Source="Nicolas_upshifts" /id="D1136" /incds=0 /nref=92 /ntot=248 /MaxReadThrough="4.04021" /MaxDrop="5.35086" /score="-1.90494373" /energy="-7" /TU="U1703" /idTUdmin="U1703" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 1881798..1883029 /Source="Nicolas_S_feature" /locus_tag="new_2288652_2289883" /HighExp="Cold, ferm, nit, C30, S0, Lbstat, T3.30H, T-4.40H, T5.0H, G135" /AntisenseName="dinF" /AntisenseCor="0.270994122332881" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S818" CDS complement(1881815..1883152) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11583854, 15849754, 16850406, 22933559, 26246409; Product type t : transporter" /codon_start=1 /transl_table=11 /product="damage inducible, Na+ driven multidrug efflux pump" /protein_id="NP_390054.1" /db_xref="EnsemblGenomes-Gn:BSU21710" /db_xref="EnsemblGenomes-Tr:CAB14089" /db_xref="GOA:P54181" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG11625" /db_xref="UniProtKB/Swiss-Prot:P54181" /translation="MKAYDFTQGNVLKQLVLFSMPIMLGNALQVSFQFIDSLWIGNLL GAKALGAAAVSSTIVLTVLSFILGLNNATLTILSQQKGKDDIKGMASYINAFVVLLTG LSIGFGAAGFFLSELLLRLLKTPESMIPLAETYLQIQFIGILFLFGYNFISTVLRALG DSKTPLRFIAFAVVLNTVLAPLFISVFRMGIAGAAYSTILSQGIAFLYGLFYVIKHKL VPFSIPRMPKWEESALILKLGIPAGLQMMVITGGMMAIMSVVNSYGDHVVSGFGAVQR LDSIITLPAMAAGTAVNSMAGQNIGIGNEKRVGTIARLGVIAVISCMLVIAVMIWVFG KYLIRLFISEPDAVAFGEQYLKWIAFFYPFIGVNFVLNGIVRAAGAMLQVLVLNLISF WVLRYPFTALFSAWLGQKGIGLGIGMSFLFSSCAAFLYYRYGRWKAMKLFTEK*" /label="dinF CDS" gene complement(1881815..1883152) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /label="dinF gene" CDS complement(1883224..1883418) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390055.1" /db_xref="EnsemblGenomes-Gn:BSU21720" /db_xref="EnsemblGenomes-Tr:CAB14090" /db_xref="GOA:P54180" /db_xref="InterPro:IPR035403" /db_xref="SubtiList:BG11624" /db_xref="UniProtKB/Swiss-Prot:P54180" /translation="MKRIYQYFSLLSFTFSLYFGWLAYHHLAAEDMDQMYLNVSYCAL FLSVMVFTFGMRDRKKTDKS*" /label="ypmT CDS" gene complement(1883224..1883418) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /label="ypmT gene" downshifts complement(1883237) /Source="Nicolas_upshifts" /id="D1137" /incds=0 /nref=123 /ntot=248 /MaxReadThrough="3.84998" /MaxDrop="4.80224" /score="-2.26655222" /energy="-15.5" /TU="U1705" /idTUdmin="U1707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1883431..1883994) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390056.1" /db_xref="EnsemblGenomes-Gn:BSU21730" /db_xref="EnsemblGenomes-Tr:CAB14091" /db_xref="GOA:P54179" /db_xref="InterPro:IPR018672" /db_xref="SubtiList:BG11623" /db_xref="UniProtKB/Swiss-Prot:P54179" /translation="MNKWKRLFFILLAINFILAAGFVALVLLPGEQAQVKDASESEYG FQVTSTKESLAAFVNSYLNDKASNKLDYKVEIDDDVHVAGKIKAFSTSIDAFIAFEPT VKKNGDVELNVTKFSLGKLSIPISFVLNYMDSFYELPSFVHVHPGDKSIEVRLSEMPL TNGMYVKADKINLEKDEIEFSYYHPKQ*" /label="ypmS CDS" gene complement(1883431..1883994) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /label="ypmS gene" CDS complement(1884004..1884771) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17220230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported lipase/acylhydrolase (lipoprotein)" /protein_id="NP_390057.1" /db_xref="EnsemblGenomes-Gn:BSU21740" /db_xref="EnsemblGenomes-Tr:CAB14092" /db_xref="GOA:P40766" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11022" /db_xref="UniProtKB/Swiss-Prot:P40766" /translation="MKLRIFSIMASLILLLTACTSIRTSSEGKQKAHETKTKEHIVIA AVGDSLTEGVGDPDGKGYVGKVADSIRSDKQVKTVDVKNYAVKGNRSDDLLEKLKDKK VQKGIKDADYVFFTIGGNDLMKILRQNFLQLTVEPFQEAEKPYEKRFEKIISEIRELN DHAELIYVSMYNPFTFTLSELNEINGVVTDWNHIAEKELKKDKHAKIVHIEDLFNQKS DSSRISEEDDFHPNGTGYSLIAKRVYQAIKKEGLPKE*" /label="ypmR CDS" gene complement(1884004..1884771) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /label="ypmR gene" promotor_-10 complement(1884795..1884814) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1884812) /Source="Nicolas_upshifts" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1884825..1884832) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1884849..1885430) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10837475, 14680962, 14766920, 16305244, 19027886, 29131589" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10837475, 14680962, 14766920, 16305244, 19027886, 29131589; Product type f : factor" /codon_start=1 /transl_table=11 /product="assembly factor BSco of the Cu(A) site of cytochrome c oxidase" /protein_id="NP_390058.2" /db_xref="EnsemblGenomes-Gn:BSU21750" /db_xref="EnsemblGenomes-Tr:CAB14093" /db_xref="GOA:P54178" /db_xref="InterPro:IPR003782" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ON4" /db_xref="PDB:1XZO" /db_xref="SubtiList:BG11622" /db_xref="UniProtKB/Swiss-Prot:P54178" /translation="MKVIKGLTAGLIFLFLCACGGQQIKDPLNYEVEPFTFQNQDGKN VSLESLKGEVWLADFIFTNCETICPPMTAHMTDLQKKLKAENIDVRIISFSVDPENDK PKQLKKFAANYPLSFDNWDFLTGYSQSEIEEFALKSFKAIVKKPEGEDQVIHQSSFYL VGPDGKVLKDYNGVENTPYDDIISDVKSASTLK*" /label="scuA CDS" gene complement(1884849..1885430) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /label="scuA gene" S_feature complement(1885431..1885546) /Source="Nicolas_S_feature" /locus_tag="new_2292285_2292400_c" /HighExp="T5.0H, T3.30H, S2, T3.0H, BC, T2.30H, T4.0H, S1, HiOs, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S819" CDS complement(1885578..1885829) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15060025, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390059.1" /db_xref="EnsemblGenomes-Gn:BSU21760" /db_xref="EnsemblGenomes-Tr:CAB14094" /db_xref="InterPro:IPR019687" /db_xref="SubtiList:BG11621" /db_xref="UniProtKB/Swiss-Prot:P54177" /translation="MLLKSLEFKRGDGIQVKVTEIPVLKEDEHYFFMLHHHLQFYLKE VFSSNSRAKVYSFRHYMKRRMKWADYQAVFHQEVLKHNA*" /label="ypmP CDS" gene complement(1885578..1885829) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /label="ypmP gene" downshifts complement(1885591) /Source="Nicolas_upshifts" /id="D1138" /incds=0 /nref=2 /ntot=117 /MaxReadThrough="4.5803" /MaxDrop="2.91481" /score="26.0320926" /energy="-21.8" /TU="U1707" /idTUdmin="U1706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1885852..1885871) /Source="Nicolas_upshift_promotors" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1885866) /Source="Nicolas_upshifts" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1885915..1887183) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /EC_number="4.3.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine dehydratase" /protein_id="NP_390060.1" /db_xref="EnsemblGenomes-Gn:BSU21770" /db_xref="EnsemblGenomes-Tr:CAB14095" /db_xref="GOA:P37946" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001721" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011820" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10673" /db_xref="UniProtKB/Swiss-Prot:P37946" /translation="MKPLLKENSLIQVKDILKAHQNVKDVVIHTPLQRNDRLSERYEC NIYLKREDLQVVRSFKLRGAYHKMKQLSSEQTENGVVCASAGNHAQGVAFSCKHLGIH GKIFMPSTTPRQKVSQVELFGKGFIDIILTGDTFDDAYKSAAECCEAESRTFIHPFDD PDVMAGQGTLAVEILNDIDTEPHFLFASVGGGGLLSGVGTYLKNVSPDTKVIAVEPAG AASYFESNKAGHVVTLDKIDKFVDGAAVKKIGEETFRTLETVVDDILLVPEGKVCTSI LELYNECAVVAEPAGALSVAALDLYKDQIKGKNVVCVVSGGNNDIGRMQEMKERSLIF EGLQHYFIVNFPQRAGALREFLDEVLGPNDDITRFEYTKKNNKSNGPALVGIELQNKA DYGPLIERMNKKPFHYVEVNKDEDLFHLLI*" /label="ilvA CDS" gene complement(1885915..1887183) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /label="ilvA gene" promotor_-10 complement(1887217..1887236) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1887236) /Source="Nicolas_upshifts" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1887248..1887255) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1887390..1887409 /Source="Nicolas_upshift_promotors" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1887393 /Source="Nicolas_upshifts" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="upshifts" CDS 1887432..1888427 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12399512, 16585774, 19763274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399512, 16585774, 19763274; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional enhancer involved in BCAA homeostasis" /protein_id="NP_390061.1" /db_xref="EnsemblGenomes-Gn:BSU21780" /db_xref="EnsemblGenomes-Tr:CAB14096" /db_xref="GOA:P54156" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013668" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11619" /db_xref="UniProtKB/Swiss-Prot:P54156" /translation="MNSAPKLNTFQHLIGEHQTFLEAKRIAKQFSLSELPVLITGKIG TGKNHFAHAIHLESSRSNEPFISVNCSTHSEETLIHELFGPNGNTGVFQKAVRGTLFL DDVWRMPASVQAQLLKALDSDTEKPRMICASADRSVEHTFRQDLFYRLNILTLTLPEL SERKSDIPLLTQHFLSNSGQQLLIDPSVFPVLEKHAFEGNVRELKNAADYMAAVSSGG TIQPYDLPPYIRGTIDGKTSKKKAKLLTLMEKAEFLFILETIKVLNEKGEPASRRIIS EHSKNTQTSLTPQQVRSRLDYLEKKDYVTKSRGRAGTKITFEGLSFIETLKNQMI*" /label="silP CDS" gene 1887432..1888427 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /label="silP gene" CDS 1888448..1889089 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16585774, 16850406, 19763274; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_390062.1" /db_xref="EnsemblGenomes-Gn:BSU21790" /db_xref="EnsemblGenomes-Tr:CAB14097" /db_xref="GOA:P54175" /db_xref="InterPro:IPR004254" /db_xref="InterPro:IPR005744" /db_xref="SubtiList:BG11620" /db_xref="UniProtKB/Swiss-Prot:P54175" /translation="MFTIKEEIANAITHGIGVLLSIPALVFLIIFAANYGSAWDIVSF TIFGVSMLLLYLSSTLLHSITHKKTKDILEIIDHSAIYVLIAGTYTPFLLGPLKGTLG FTLLVIVWSLALGGIVFKIFFVKRFILLSTFVYLVMGWLMIIAVKPLYASLSGAGFSL LFLGGILYSVGTIFYIWKKIPFHHAIWHSFVLGGSAAMFFCVLFYCVKVPFLS*" /label="yplQ CDS" gene 1888448..1889089 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /label="yplQ gene" S_feature 1889090..1890191 /Source="Nicolas_S_feature" /locus_tag="new_2295944_2297045" /HighExp="Cold, C30, Sw, BC, G135, LoTm, Fru, C90, BI, S0" /AntisenseName="ypkP" /AntisenseCor="0.28434605181220002" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S820" CDS complement(1889128..1889748) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 1-acyl-sn-glycerol-3-phosphate acyltransferase" /protein_id="NP_390063.2" /db_xref="EnsemblGenomes-Gn:BSU21800" /db_xref="EnsemblGenomes-Tr:CAB14098" /db_xref="SubtiList:BG11618" /db_xref="UniProtKB/Swiss-Prot:P54174" /translation="MVRYSLLVVYIVYMLLKNMKQLFNQTMLDPRLSYKKQMALVYEQ PKAFLEGCIGISGSVVTIHQPEPIPHGPVLYVHPRLRLAELALIAGYIEEPAGFIANP KVFRLPFIGQWLDRMDVISDGDSEKVYEDVTKQLEKGQSLILSLDGSIDPVELAARYH LPLVMVETKGTDNMQNGSFFKRLKPADIELSFSKAYIPANEKQLRA*" /label="ypkP CDS" gene complement(1889128..1889748) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /label="ypkP gene" downshifts complement(1889154) /Source="Nicolas_upshifts" /id="D1139" /incds=0 /nref=72 /ntot=241 /MaxReadThrough="1.32187" /MaxDrop="5.02823" /score="16.0584527" /energy="-13.4" /TU="NA" /idTUdmin="U1710" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1889749..1890255) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /EC_number="1.5.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2840350, 3918568, 10574451, 12682299, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2840350, 3918568, 10574451, 12682299, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydrofolate reductase" /protein_id="NP_390064.1" /db_xref="EnsemblGenomes-Gn:BSU21810" /db_xref="EnsemblGenomes-Tr:CAB14099" /db_xref="GOA:P11045" /db_xref="InterPro:IPR001796" /db_xref="InterPro:IPR012259" /db_xref="InterPro:IPR017925" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG10795" /db_xref="UniProtKB/Swiss-Prot:P11045" /translation="MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGR KTFESIGRPLPNRKNIVVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYT DLFPYADRLYMTKIHHEFEGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK NSSKAGGF*" /label="dfrA CDS" gene complement(1889749..1890255) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /label="dfrA gene" CDS complement(1890252..1891046) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9648749, 10574451, 19732150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9648749, 10574451, 19732150; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase B" /protein_id="NP_390065.1" /db_xref="EnsemblGenomes-Gn:BSU21820" /db_xref="EnsemblGenomes-Tr:CAB14100" /db_xref="GOA:P11044" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="SubtiList:BG10794" /db_xref="UniProtKB/Swiss-Prot:P11044" /translation="MKQYKDFCRHVLEHGEKKGDRTGTGTISTFGYQMRFNLREGFPM LTTKKLHFKSIAHELLWFLKGDTNVRYLQENGVRIWNEWADENGELGPVYGSQWRSWR GADGETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKMALPPCHCLFQFYVSDGKLS CQLYQRSADVFLGVPFNIASYALLTMIIAHVTGLEPGEFIHTFGDVHIYQNHIEQVNL QLERDVRPLPQLRFARKVDSIFNFAFEDFIIEDYDPHPHIKGAVSV*" /label="thyB CDS" gene complement(1890252..1891046) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /label="thyB gene" CDS complement(1891130..1891663) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8534098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_390066.1" /db_xref="EnsemblGenomes-Gn:BSU21830" /db_xref="EnsemblGenomes-Tr:CAB14101" /db_xref="GOA:P54173" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="PDB:1TLQ" /db_xref="SubtiList:BG11617" /db_xref="UniProtKB/Swiss-Prot:P54173" /translation="MKKYTMNEMVDITKDMLNKRGVMIEDIARIVQKLQEKYNPNLPL SVCMENVEKVLNKREIIHAVLTGLALDQLAEQKLLPEPLQHLVETDEPLYGIDEIIPL SIVNVYGSIGLTNFGYLDKEKIGIIKELDESPDGIHTFLDDIVAALAAAAASRIAHTH QDLQDEEKEQDEKPVVS*" /label="ypjQ CDS" gene complement(1891130..1891663) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /label="ypjQ gene" downshifts complement(1891135) /Source="Nicolas_upshifts" /id="D1140" /incds=0 /nref=17 /ntot=167 /MaxReadThrough="4.91561" /MaxDrop="4.18561" /score="15.5758445" /energy="-9.3" /TU="U1710" /idTUdmin="U1711" /TUdmin=1232 /isTUend="FALSE" /label="downshifts" promotor_-35 1891593..1891598 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1891609..1892555 /Source="Nicolas_S_feature" /locus_tag="new_2298463_2299409" /HighExp="S5, S6, S4, S8, S7, S3, B36, BT, B60, T5.0H" /AntisenseName="ypjP" /AntisenseCor="-0.72590712604537599" /AntisenseRegPval="-44.6" /CDS_PredictionProba="0.99932399999999999" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S821" upshifts 1891611 /Source="Nicolas_upshifts" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1891615..1891633 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1891681..1892292) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390067.1" /db_xref="EnsemblGenomes-Gn:BSU21840" /db_xref="EnsemblGenomes-Tr:CAB14102" /db_xref="GOA:P54172" /db_xref="InterPro:IPR025616" /db_xref="SubtiList:BG11616" /db_xref="UniProtKB/Swiss-Prot:P54172" /translation="MKLWMRKTLVVLFTIVTFGLVSPPAALMADKPSGQPSSLEQNDY TAFYDEHDLYDDESDDRRDPELLFQSYKEQLLDSAEDQSFLKFGSRIAPVIEDDYRKE ILPKIENVISDYLATLQDDEAYQDVVISSMPSAGKTEKIFNVYNRTTGEDLLRFHVRR DHPPHDGYWFNFHYHTAEDGFQSHHELGSIYWDRNTPPNWMSA*" /label="ypjP CDS" gene complement(1891681..1892292) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /label="ypjP gene" promotor_-10 complement(1892324..1892343) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1892343) /Source="Nicolas_upshifts" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1892356..1892361) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1892512 /Source="Nicolas_upshifts" /id="D1141" /incds=0 /nref=57 /ntot=234 /MaxReadThrough="3.131" /MaxDrop="5.18613" /score="2.81720493" /energy="-15" /TU="U1709" /idTUdmin="U1709" /TUdmin="-527" /isTUend="FALSE" /label="downshifts" CDS complement(1892552..1893325) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /EC_number="2.1.1.242" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22079366; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 16S rRNA m(2)G1516 methyltransferase" /protein_id="NP_390068.2" /db_xref="EnsemblGenomes-Gn:BSU21850" /db_xref="EnsemblGenomes-Tr:CAB14103" /db_xref="GOA:P54171" /db_xref="InterPro:IPR007536" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11615" /db_xref="UniProtKB/Swiss-Prot:P54171" /translation="MITTSYRPSEHTIKTAKQLSKELNMPYCGRNKQTVEHLLKSAER DLLVVGKERFELYTKQGAKFFFHPNTAMFRAKRFLQGEKEPMLRAAGLSEGDTFLDCT LGLGSDAIIASMAVGETGSVVGIEKNHLVSVLVRTGLHSWETGIEELQAAMRRIQVKN GDCFEHIKQLPDNSVDVVYFDPMFHEPVETSDGIAPLRDLAEDSVLHEGCINEAVRVA RKSVVLKDHWKSPRFEQFGFNVMKRKTALFHYGVIQTSP*" /label="rsmJ CDS" gene complement(1892552..1893325) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /label="rsmJ gene" downshifts complement(1892587) /Source="Nicolas_upshifts" /id="D1142" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="2.86923" /MaxDrop="2.91228" /score="9.10717118" /energy="-15" /TU="U1711" /idTUdmin="U1711" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(1893367..1893801) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19653655, 21749987, 22938038, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19653655, 21749987, 22938038, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein disulfide isomerase; bacilliredoxin A (de-bacillithiolation)" /protein_id="NP_390069.1" /db_xref="EnsemblGenomes-Gn:BSU21860" /db_xref="EnsemblGenomes-Tr:CAB14104" /db_xref="InterPro:IPR009474" /db_xref="PDB:3FHK" /db_xref="SubtiList:BG11614" /db_xref="UniProtKB/Swiss-Prot:P54170" /translation="MSMAYEEYMRQLVVPMRRELTGAGFEELTTAEEVENFMEKAEGT TLVVVNSVCGCAAGLARPAATQAVLQNDKTPDNTVTVFAGQDKEATAKMREYFTGQEP SSPSMALLKGKEVVHFIPRHEIEGHDMEEIMKNLTAAFDAHC*" /label="brxA CDS" gene complement(1893367..1893801) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /label="brxA gene" downshifts complement(1893379) /Source="Nicolas_upshifts" /id="D1143" /incds=0 /nref=9 /ntot=210 /MaxReadThrough="5.2935" /MaxDrop="3.1992" /score="21.0933404" /energy="-9.7" /TU="U1711,U1712" /idTUdmin="U1712" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1893830..1893849) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-10" upshifts complement(1893841) /Source="Nicolas_upshifts" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="upshifts" S_feature complement(1893843..1893907) /Source="Nicolas_S_feature" /locus_tag="new_2300697_2300761_c" /HighExp="Sw, S1, BC, Gly, HiOs, HiTm, GM-0.1, UNK1, Fru, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S822" promotor_-35 complement(1893863..1893870) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-35" downshifts complement(1893886) /Source="Nicolas_upshifts" /id="D1144" /incds=0 /nref=32 /ntot=128 /MaxReadThrough="5.73826" /MaxDrop="4.95094" /score="26.9702838" /energy="-25.8" /TU="U1712" /idTUdmin="U1713" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1893908..1895584) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /EC_number="4.2.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12193635, 12618455, 15060025, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193635, 12618455, 15060025, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxy-acid dehydratase" /protein_id="NP_390070.2" /db_xref="EnsemblGenomes-Gn:BSU21870" /db_xref="EnsemblGenomes-Tr:CAB14105" /db_xref="GOA:P51785" /db_xref="InterPro:IPR000581" /db_xref="InterPro:IPR004404" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR020558" /db_xref="SubtiList:BG11532" /db_xref="UniProtKB/Swiss-Prot:P51785" /translation="MAELRSNMITQGIDRAPHRSLLRAAGVKEEDFGKPFIAVCNSYI DIVPGHVHLQEFGKIVKEAIREAGGVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIAD SVETVVSAHWFDGMVCIPNCDKITPGMLMAAMRINIPTIFVSGGPMAAGRTSDGRKIS LSSVFEGVGAYQAGKINENELQELEQFGCPTCGSCSGMFTANSMNCLSEALGLALPGN GTILATSPERKEFVRKSAAQLMETIRKDIKPRDIVTVKAIDNAFALDMALGGSTNTVL HTLALANEAGVEYSLERINEVAERVPHLAKLAPASDVFIEDLHEAGGVSAALNELSKK EGALHLDALTVTGKTLGETIAGHEVKDYDVIHPLDQPFTEKGGLAVLFGNLAPDGAII KTGGVQNGITRHEGPAVVFDSQDEALDGIINRKVKEGDVVIIRYEGPKGGPGMPEMLA PTSQIVGMGLGPKVALITDGRFSGASRGLSIGHVSPEAAEGGPLAFVENGDHIIVDIE KRILDVQVPEEEWEKRKANWKGFEPKVKTGYLARYSKLVTSANTGGIMKI*" /label="ilvD CDS" gene complement(1893908..1895584) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /label="ilvD gene" S_feature complement(1895585..1895775) /Source="Nicolas_S_feature" /locus_tag="new_2302439_2302629_c" /HighExp="S1, T-5.40H, MG 45, HiOs, T-4.40H, MG 120, UNK1, MG 25, MG-0.2, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.97" /TUlongSig="SigH" /TUlongPSig=1 /label="S823" promotor_-10 complement(1895764..1895783) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1895775) /Source="Nicolas_upshifts" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1895798..1895801) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1895873..1897006) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase or scaffold" /protein_id="NP_390071.1" /db_xref="EnsemblGenomes-Gn:BSU21880" /db_xref="EnsemblGenomes-Tr:CAB14106" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR014824" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR025989" /db_xref="InterPro:IPR036498" /db_xref="SubtiList:BG11613" /db_xref="UniProtKB/Swiss-Prot:P54169" /translation="MKIKSIEPTPSPNTMKVILTEELPAGKSNNYKPEQAEGAPLVIA EILKIDGVKGVYHVADFLAVERNARYDWKDILPQVRTAFGMESAESAEENRSDQESFG EVKVFVQMFSGIPMQVKLTDGEREERFGLPERFQQAILKLRSEASNVVFERAWKEQGV RFGDFDEIGHDVTEELQAAYSDERLKRLTEAAAQGKGEAKQAVQRKAYKVTLDMLDDE DWKKRYAHLEQMDPKEEDIPVLQKALDDPKVSIRRQAVVYLGMIETPDVLPLLYKALE DKAVSVRRTAGDCLSDIGDPQAIPAMIKSLSDSSKLVRWRAAMFLYEVGDESAIEALR AAEDDPEFEVSLQVKMALERIEHGEEAKGSVWKQMTESRKKGE*" /label="ypgR CDS" gene complement(1895873..1897006) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /label="ypgR gene" downshifts complement(1895889) /Source="Nicolas_upshifts" /id="D1145" /incds=0 /nref=193 /ntot=249 /MaxReadThrough="5.33526" /MaxDrop="6.88149" /score="18.2078317" /energy="-8.7" /TU="U1713" /idTUdmin="U1714" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature complement(1897028..1897047) /Source="Nicolas_upshift_promotors" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1897031) /Source="Nicolas_upshifts" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1897066..1897683) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /EC_number="3.6.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25005104, 27062940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25005104, 27062940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Mn(2+)-dependent (deoxy)ribonucleoside pyrophosphohydrolase" /protein_id="NP_390072.1" /db_xref="EnsemblGenomes-Gn:BSU21890" /db_xref="EnsemblGenomes-Tr:CAB14107" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11612" /db_xref="UniProtKB/Swiss-Prot:P54168" /translation="MKELKQAEQIRTWVQSILTDESSGHDWHHVSRVADLAAYIGEKE KADLFIVETAALVHDLIDVKLPDTVRLSVSEVYDQLVFFGVGKENADRVIHIITRMSF RDRGKLAKEPLSIEGKAVQDADRLDAIGAVGIARAFMFAGAKGHGLYGDEQSAYAHFF HKLLRLKDMMNTDTARELAEERHNFMLQFVRQLEKDIPGIDAETS*" /label="hdhQ CDS" gene complement(1897066..1897683) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /label="hdhQ gene" CDS complement(1897699..1898181) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /EC_number="1.11.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14563871, 14617062, 21749987, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol peroxidase" /protein_id="NP_390073.1" /db_xref="EnsemblGenomes-Gn:BSU21900" /db_xref="EnsemblGenomes-Tr:CAB14108" /db_xref="GOA:P52035" /db_xref="InterPro:IPR000889" /db_xref="InterPro:IPR029759" /db_xref="InterPro:IPR029760" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11530" /db_xref="UniProtKB/Swiss-Prot:P52035" /translation="MSIYHMKVRTITGKDMTLQPFAGKVLMIVNTASKCGFTSQLKQL QELYDTYQQEGLEILGFPCNQFMNQEPGEEADIQEFCETNYGVTFPMFSKVDVNGKNA HPLFVYLTEHAKGMLGTKAIKWNFTKFIVDRNGEIVGRYSPNTNPKELEDDIVKLLEQ *" /label="bsaA CDS" gene complement(1897699..1898181) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /label="bsaA gene" S_feature complement(1898182..1898329) /Source="Nicolas_S_feature" /locus_tag="new_2305036_2305183_c" /HighExp="S2, HiOs, S1, Etha, T2.30H, T3.0H, Lbtran, M0t90, T2.0H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S824" promotor_-10 complement(1898320..1898338) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-10" upshifts complement(1898330) /Source="Nicolas_upshifts" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="upshifts" promotor_-35 complement(1898349..1898357) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-35" promotor_-35 1898383..1898392 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 1898405..1898420 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" S_feature 1898407..1898493 /Source="Nicolas_S_feature" /locus_tag="new_2305261_2305347" /HighExp="Salt, T-0.40H, T-1.10H, Heat, T-1.40H, H2O2, T0.0H, Paraq, T0.30H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S825" upshifts 1898407 /Source="Nicolas_upshifts" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" promotor_-35 1898456..1898463 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 1898478..1898497 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" upshifts 1898495 /Source="Nicolas_upshifts" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" CDS 1898524..1899429 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /EC_number="2.3.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5001847, 10939241, 11832514, 17056751, 18216013, 28581482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5001847, 10939241, 11832514, 17056751, 18216013, 28581482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="homoserine O-acetyltransferase" /protein_id="NP_390074.2" /db_xref="EnsemblGenomes-Gn:BSU21910" /db_xref="EnsemblGenomes-Tr:CAB14109" /db_xref="GOA:P54167" /db_xref="InterPro:IPR005697" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033752" /db_xref="SubtiList:BG11534" /db_xref="UniProtKB/Swiss-Prot:P54167" /translation="MPINIPTHLPAKQVLESEHIFVMDESRAFHQDIRPQKIIILNLM PKKIQTETQLLRLLGNSPLQVHFTFLIPSTHTPKNTAREHLDEFYTTFSNIRHKRFDG MIITGAPIEHLAFEEVSYWEELKEIMEWSKTNVTSTLHICWGAQAGLYYHYGVEKIQM PKKIFGVFEHTVLSKHERLVRGFDELYYVPHSRHTDINMEQLQAVPELNILTASKEAG VCLIVSKDEKQVFLTGHPEYDTNTLLQEYERDLERNLSTVEAPKHYFAKGSNEPVNRW KAHATLLFMNWLNYYVYQETPYEWD*" /label="metAA CDS" gene 1898524..1899429 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /label="metAA gene" misc_feature 1899464..1899483 /Source="Nicolas_upshift_promotors" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1899478 /Source="Nicolas_upshifts" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" S_feature 1899479..1899659 /Source="Nicolas_S_feature" /locus_tag="new_2306333_2306513" /HighExp="Heat, HiTm, LoTm, C90, M9-stat, HiOs, SMM, UNK1, MG 25, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.999, 0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S826" CDS 1899660..1900808 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /EC_number="2.4.1.315" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose diacylglyceroltransferase" /protein_id="NP_390075.1" /db_xref="EnsemblGenomes-Gn:BSU21920" /db_xref="EnsemblGenomes-Tr:CAB14110" /db_xref="GOA:P54166" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR009695" /db_xref="InterPro:IPR023589" /db_xref="SubtiList:BG11611" /db_xref="UniProtKB/Swiss-Prot:P54166" /translation="MNTNKRVLILTANYGNGHVQVAKTLYEQCVRLGFQHVTVSNLYQ ESNPIVSEVTQYLYLKSFSIGKQFYRLFYYGVDKIYNKRKFNIYFKMGNKRLGELVDE HQPDIIINTFPMIVVPEYRRRTGRVIPTFNVMTDFCLHKIWVHENVDKYYVATDYVKE KLLEIGTHPSNVKITGIPIRPQFEESMPVGPIYKKYNLSPNKKVLLIMAGAHGVLKNV KELCENLVKDDQVQVVVVCGKNTALKESLSALEAENGDKLKVLGYVERIDELFRITDC MITKPGGITLTEATAIGVPVILYKPVPGQEKENANFFEDRGAAIVVNRHEEILESVTS LLADEDTLHRMKKNIKDLHLANSSEVILEDILKESEMMTAKQKAKVLS*" /label="ugtP CDS" gene 1899660..1900808 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /label="ugtP gene" S_feature complement(1899829..1900858) /Source="Nicolas_S_feature" /locus_tag="new_2306683_2307712_c" /HighExp="S8, S7, S6, C30, Lbstat, T0.30H, C90, BT, G135, Fru" /AntisenseName="ugtP" /AntisenseCor="-0.328222465122327" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S827" downshifts 1900804 /Source="Nicolas_upshifts" /id="D1146" /incds=0 /nref=77 /ntot=240 /MaxReadThrough="4.0787" /MaxDrop="4.20549" /score="21.6989702" /energy="-12.1" /TU="U1715,U1717" /idTUdmin="U1716" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1900840..1900859) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1900858) /Source="Nicolas_upshifts" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1900874..1900882) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1900889..1901035 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513973.1" /translation="MELALLLKNKPFRNLTGAPRWCIVEPSFNNESKLDDDKIFFSTW VLQY*" /label="hypothetical protein CDS" gene 1900889..1901035 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /label="gene" promotor_-35 1900928..1900935 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1900949..1900968 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1900960..1901050 /Source="Nicolas_S_feature" /locus_tag="new_2307814_2307904" /HighExp="C90, T5.0H, T3.30H, T3.0H, HiOs, Salt, LoTm, T-3.40H, S3, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S828" upshifts 1900960 /Source="Nicolas_upshifts" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 1901051..1901251 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9920884, 16352840" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9920884, 16352840; Product type f: factor" /codon_start=1 /transl_table=11 /product="cold-shock protein, molecular chaperone, RNA-helicase co-factor" /protein_id="NP_390076.1" /db_xref="EnsemblGenomes-Gn:BSU21930" /db_xref="EnsemblGenomes-Tr:CAB14111" /db_xref="GOA:P51777" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11531" /db_xref="UniProtKB/Swiss-Prot:P51777" /translation="MQNGKVKWFNNEKGFGFIEVEGGDDVFVHFTAIEGDGYKSLEEG QEVSFEIVEGNRGPQASNVVKL*" /label="cspD CDS" gene 1901051..1901251 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /label="cspD gene" downshifts 1901266 /Source="Nicolas_upshifts" /id="D1147" /incds=0 /nref=257 /ntot=269 /MaxReadThrough="5.19931" /MaxDrop="8.09346" /score="9.24662311" /energy="-15.6" /TU="U1719" /idTUdmin="U1715" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS complement(1901303..1901485) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16625836, 19251843, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16625836, 19251843, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of degradative enzymes (aprE, nprE, sacB) production or activity" /protein_id="NP_390077.1" /db_xref="EnsemblGenomes-Gn:BSU21940" /db_xref="EnsemblGenomes-Tr:CAB14112" /db_xref="GOA:P68731" /db_xref="SubtiList:BG10699" /db_xref="UniProtKB/Swiss-Prot:P68731" /translation="MDDKDLKLILHKTFIEIYSDLEELADIAKKGKPSMEKYVEEIEQ RCKQNILAIEIQMKIK*" /label="degR CDS" gene complement(1901303..1901485) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /label="degR gene" S_feature 1901311..1901616 /Source="Nicolas_S_feature" /locus_tag="new_2308165_2308470" /HighExp="Cold, LoTm, T4.0H, T3.30H, Pyr, T5.0H, Gly, T3.0H, S0, C30" /AntisenseName="degR" /AntisenseCor="-0.145220711637392" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S829" downshifts complement(1901320) /Source="Nicolas_upshifts" /id="D1148" /incds=0 /nref=133 /ntot=216 /MaxReadThrough="3.75638" /MaxDrop="5.32427" /score="16.1392275" /energy="-7.3" /TU="U1720" /idTUdmin="U1720" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1901546..1901564) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1901578..1901584) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1901582) /Source="Nicolas_upshifts" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1901592..1901598 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1901613..1901624 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1901618 /Source="Nicolas_upshifts" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 1901641..1901910 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390078.1" /db_xref="EnsemblGenomes-Gn:BSU21950" /db_xref="EnsemblGenomes-Tr:CAB14113" /db_xref="InterPro:IPR020314" /db_xref="SubtiList:BG13764" /db_xref="UniProtKB/Swiss-Prot:O32007" /translation="MTSEFHNEDQTGFTDKRQLELAVETAQKTTGAATRGQSKTLVDS AYQAIEDARELSQSEELAALDDPEFVKQQQQLLDDSEHQLDEFKE*" /label="ypzA CDS" gene 1901641..1901910 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /label="ypzA gene" downshifts 1901765 /Source="Nicolas_upshifts" /id="D1149" /incds=1 /nref=3 /ntot=82 /MaxReadThrough="6.79633" /MaxDrop="4.11501" /score="22.0113838" /energy="-7.3" /TU="U1719,U1721" /idTUdmin="U1719" /TUdmin="-117" /isTUend="FALSE" /label="downshifts" downshifts 1901893 /Source="Nicolas_upshifts" /id="D1150" /incds=0 /nref=18 /ntot=94 /MaxReadThrough="2.31821" /MaxDrop="6.65627" /score="22.0113838" /energy="-7.3" /TU="NA" /idTUdmin="U1719" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(1901938..1902120) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390079.1" /db_xref="EnsemblGenomes-Gn:BSU21960" /db_xref="EnsemblGenomes-Tr:CAB14114" /db_xref="InterPro:IPR019718" /db_xref="SubtiList:BG11610" /db_xref="UniProtKB/Swiss-Prot:P54165" /translation="MDKKMIFKELTELHDEYCKDCFIKKQFRKEFGKTYAHSFCINKC TVGEKLKQYGDVLTNH*" /label="ypeQ CDS" gene complement(1901938..1902120) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /label="ypeQ gene" downshifts complement(1901958) /Source="Nicolas_upshifts" /id="D1151" /incds=0 /nref=5 /ntot=102 /MaxReadThrough="2.77117" /MaxDrop="4.29218" /score="16.1392275" /energy="-7.3" /TU="NA" /idTUdmin="U1723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1902113..1902793) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12562816, 17905985, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 17905985, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease" /protein_id="NP_390080.2" /db_xref="EnsemblGenomes-Gn:BSU21970" /db_xref="EnsemblGenomes-Tr:CAB14115" /db_xref="GOA:P54164" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11609" /db_xref="UniProtKB/Swiss-Prot:P54164" /translation="MKLRPHLKIEAKGTGSVSFFSEDWLTAQQARTFARELGRFPYMK ELEFEDEKGGSWTLKELEKLTEELAQEPDDITVYFDGSFDKESELAGLGIVIYYSLGG TRHRLRKNKSFRLKTNNEAEYAALYEAIREVRELGASRNSITIKGDSLVVLNQLDGSW PCYDPSHNEWLDKIEALLESLKLTPTYETIQRKDNQEADGLAKKILSHQFVESHTKLD RNGDDDIG*" /label="ypeP CDS" gene complement(1902113..1902793) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /label="ypeP gene" S_feature complement(1902794..1902931) /Source="Nicolas_S_feature" /locus_tag="new_2309648_2309785_c" /HighExp="S5, S4, S6, S8, S7, S3, T5.0H, T4.0H, BT, Pyr" /AntisenseName="ypdP" /AntisenseCor="-0.65324924042743404" /AntisenseRegPval="-33.4" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.92, 0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S830" promotor_-35 1902810..1902815 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1902828..1902847 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1902833 /Source="Nicolas_upshifts" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 1902876..1903565 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28208705; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preQ0 transporter (promiscuous)" /protein_id="NP_390081.1" /db_xref="EnsemblGenomes-Gn:BSU21980" /db_xref="EnsemblGenomes-Tr:CAB14116" /db_xref="GOA:P54163" /db_xref="InterPro:IPR003744" /db_xref="SubtiList:BG11607" /db_xref="UniProtKB/Swiss-Prot:P54163" /translation="MFNNSFWIFFAIIHFIIVLLFYKGFGKMGLFVWIGFATVCANLQ VVKTVELFGLTATLGNVMYGTIFFATDVLNEKYGPAEARKAVWLGFSTLLTLTFVMQG VLLFEPASSDISQTALETIFGFLPRVALGSLLAFIFSQTLDVYVYSAIRRIFPSDRLL WLRNGGSTAVSQLFDTFIFTAVAFLGIYPADVWLHIFISTYLIKFAVSLISLPYAYAA KKMIPNDERSS*" /label="queP CDS" gene 1902876..1903565 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /label="queP gene" promotor_-35 complement(1902929..1902945) /Source="Nicolas_upshift_promotors" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1902932) /Source="Nicolas_upshifts" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1902933..1903322) /Source="Nicolas_S_feature" /locus_tag="new_2309787_2310176_c" /HighExp="S5, S4, S6, S7, S8, T5.0H, S3, T4.0H, BT, M9-stat" /AntisenseName="ypdP" /AntisenseCor="-0.645700204826543" /AntisenseRegPval="-32.4" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S831" promotor_-10 complement(1903303..1903322) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1903320) /Source="Nicolas_upshifts" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1903334..1903342) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1903565..1903963 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9888800, 10094689, 15115438, 17905985; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein (no RNase H activity)" /protein_id="NP_390082.1" /db_xref="EnsemblGenomes-Gn:BSU21990" /db_xref="EnsemblGenomes-Tr:CAB14117" /db_xref="GOA:P54162" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11608" /db_xref="UniProtKB/Swiss-Prot:P54162" /translation="MPTEIYVDGASAGNPGPSGIGIFIKHEGKAESFSIPIGVHTNQE AEFLALIEGMKLCATRGYQSVSFRTDSDIVERATELEMVKNITFQPFVEEIIRLKAAF PLFFIKWIPGKQNQKADLLAKEAIRLNEKN*" /label="ypdQ CDS" gene 1903565..1903963 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /label="ypdQ gene" promotor_-35 1903956..1903962 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1903977..1903988 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1903988 /Source="Nicolas_upshifts" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 1904005..1904133 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054584.1" /db_xref="EnsemblGenomes-Gn:BSU22000" /db_xref="EnsemblGenomes-Tr:CAE01458" /db_xref="GOA:Q7WY66" /db_xref="InterPro:IPR017526" /db_xref="SubtiList:BG14176" /db_xref="UniProtKB/Swiss-Prot:Q7WY66" /translation="MKKKDKGRLTGGVTPQGDLEGNTHNDPKTELEERAKKSNTKR*" /label="sspL CDS" gene 1904005..1904133 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /label="sspL gene" S_feature 1904134..1905114 /Source="Nicolas_S_feature" /locus_tag="new_2310988_2311968" /HighExp="S8, S7, S5, S6, S4, C30, nit, ferm, Pyr, S3" /AntisenseName="exoA" /AntisenseCor="-0.365099613028674" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S832" CDS complement(1904141..1905031) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:16045613, 17038322, 17905985, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16045613, 17038322, 17905985, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5'3'-exonuclease" /protein_id="NP_390083.1" /db_xref="EnsemblGenomes-Gn:BSU22010" /db_xref="EnsemblGenomes-Tr:CAB14118" /db_xref="GOA:P54161" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="SubtiList:BG11606" /db_xref="UniProtKB/Swiss-Prot:P54161" /translation="MNNNKLLLVDGMALLFRAFFATAVHRNFMINDSGVPTNGVNGFL KHLITAVETFQPTHVVCCWDMGSKTYRNDLFQDYKANRSAPPVELIPQFDLAKEAAAE LGIMNIGFAGYEADDCIGTLADLFANEADITVVTGDRDLLQLLTDKVSVALLQKGIGN YKVYTKETFYEETGVMPKALIDIKALMGDSSDNYPGVKGIGEKTAYKLIREYETIDRL LENLSLLPKGQQGKIQQGLSDLEMSRKLAEIHCSVPLACTLKDALFTLQMEQAADMLR RHQIKGIERMLEKLNAREIV*" /label="exnP CDS" gene complement(1904141..1905031) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /label="exnP gene" downshifts complement(1904178) /Source="Nicolas_upshifts" /id="D1152" /incds=0 /nref=10 /ntot=174 /MaxReadThrough="2.94148" /MaxDrop="4.49836" /score="3.60870815" /energy="-15.6" /TU="U1726" /idTUdmin="U1726" /TUdmin="-284" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1905053..1905072) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1905060) /Source="Nicolas_upshifts" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1905084..1905090) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1905088 /Source="Nicolas_upshifts" /id="D1153" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="0.83304" /MaxDrop="4.41573" /score="0.126370352" /energy="-15" /TU="NA" /idTUdmin="U1725" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(1905132..1905278) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097753.1" /db_xref="EnsemblGenomes-Gn:BSU22019" /db_xref="EnsemblGenomes-Tr:CAX52652" /db_xref="UniProtKB/Swiss-Prot:C0H443" /translation="MLGRTKLGNRNAQANNNAKKKNGFQTHFDSYAGREAEKLIASNK RHND*" /label="ypzF CDS" gene complement(1905132..1905278) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /label="ypzF gene" downshifts complement(1905148) /Source="Nicolas_upshifts" /id="D1154" /incds=0 /nref=253 /ntot=272 /MaxReadThrough="0.89691" /MaxDrop="8.47168" /score="25.632979" /energy="-12" /TU="NA" /idTUdmin="U1727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1905302) /Source="Nicolas_upshifts" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1905303..1905314) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1905329..1905335) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1905353..1905610) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /experiment="publication(s) with functional evidences, PMID:20709900, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore associated protein" /protein_id="NP_390084.1" /db_xref="EnsemblGenomes-Gn:BSU22020" /db_xref="EnsemblGenomes-Tr:CAB14119" /db_xref="InterPro:IPR019688" /db_xref="SubtiList:BG11605" /db_xref="UniProtKB/Swiss-Prot:P54160" /translation="MSEVHKAISAHSSKQHEHIKAFMRLENMRELAIEEAVAKCRNDE PYTTDAINEITEQMNQLAKKGIVPTRRLVSKEMVREYVSRM*" /label="ypbS CDS" gene complement(1905353..1905610) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /label="ypbS gene" promotor_-10 complement(1905630..1905649) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1905645) /Source="Nicolas_upshifts" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1905661..1905668) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1905675..1909256) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /EC_number="3.6.5.5" /experiment="publication(s) with functional evidences, PMID:21205012, 23388828, 23249255, 26842743, 26530236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21205012, 23388828, 23249255, 26842743, 26530236; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dynamin GTPase" /protein_id="NP_390085.1" /db_xref="EnsemblGenomes-Gn:BSU22030" /db_xref="EnsemblGenomes-Tr:CAB14120" /db_xref="GOA:P54159" /db_xref="InterPro:IPR022812" /db_xref="InterPro:IPR027094" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11604" /db_xref="UniProtKB/Swiss-Prot:P54159" /translation="MTDQNRKELLHKTGELYKQFIENQDEQRAAKLAAVMKKAADEEV YIAFTGHYSAGKSSLLNCLLMENILPTSPIPTSANLVVIRNGEKRVRLHTTDGACAEL EGTYQKDKVQQYCKDGEQIESVEIFDRYTEIDSGVAYIDTPGIDSTDDAHFLSAASIL HQADALFYVVHYNHVHAEENVKFLRSIKESIPNVYFIVNQIDRHDETETKFGDYQAQV EEMLCNEGISREALYFTSVTEPDHPFNQMGALREELSRIEQQSKSNMQALTEQKVRNL LKEHTEMLKKDETGAPSFAEQLNIHTGLVQSLRDQLDEAEKQMTEAEKRMQEEINRIL KNANLTPFEMRELAAAFLESQEPSFKTGFFFSKAKTAQERDKRRNAFFSDVAKRTEAE ADWHMIDTLHKLAKVFDVYTAESEKLIQAYRTPLDISIIEHAVKHGAAFSSEYVLQYT KDLAELIRKEAKREAADIIKVLSAMVKERVSKDVQTINDRLVQESEKLVFLQEQARLE NNAREKTDRLWAIWEEESACPMHIDTEWFKSKKTRVAAPEQKQGRSQLTAQPMPKSEI KMEQEMPLQDQIKRFYTLSDILGECSMLLKQTSAFRERVKRLEERKFTLALFGGFSSG KSSFANALVGERVLPSSPTPTTATINKITKPINGNLNKTANVVFKTEDDLTAEILQLT GIPKEPAGRSFTEKWEKAVKKNRLQEEHVKLISNFLLAYEKYQQYIQEQKKLTIPLSE LKPYVAEETTACAVKEVTVYYTCPLTEKGITIVDTPGASSMNKRHTELAFQYIKDADA FFYMTYYQHSFSKGDRSFLRKLGLVKESLSMDKMFFIINAADLAKDKTELETVTDYVS AELVKEGVYEPQLFTVSSKEELVGKPESFYNQFSKVRKHLDRFIEVDVKKASAAQLSS EADKLCETVFQLHQSQHQSREEKEAQKQCLMLSFERTAADIEKRRNSKTIIEKVKKDT REQLYHIAQRLSYFANDLLKSAFHPGLQNGDWKKNVSKAMTTALHEYLFEYIQEIKTL DVRMSGFIERHINEEWLDHFQKTLNEDGYFSVYAGDQHSNGIQLKEVEPEIEERAFEQ ELKEIKSPKQFFEQKGKATFIEAVRMKLTKITEAWIKNEEESLISHYTAHLRRLQEDM GEKAIAQITDQKETYLRGYAEGEHAKEIEMAYQACISWKNSDNTIKM*" /label="dynA CDS" gene complement(1905675..1909256) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /label="dynA gene" S_feature complement(1909257..1909328) /Source="Nicolas_S_feature" /locus_tag="new_2316111_2316182_c" /HighExp="LBGstat, T1.30H, T1.0H, BMM, T2.30H, M9-stat, MG 150, T0.30H, T2.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S833" misc_feature complement(1909318..1909337) /Source="Nicolas_upshift_promotors" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1909328) /Source="Nicolas_upshifts" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="upshifts" S_feature complement(1909373..1909570) /Source="Nicolas_S_feature" /locus_tag="new_2316227_2316424_c" /HighExp="HiOs, B60, GM 25, S7, GM 15, B36, S5, S8, GM 5, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.24118200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S834" downshifts complement(1909416) /Source="Nicolas_upshifts" /id="D1155" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.11615" /MaxDrop="3.46525" /score="27.1937922" /energy="-9.7" /TU="U1730" /idTUdmin="U1730" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1909432..1909521) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513974.1" /db_xref="EnsemblGenomes-Gn:BSU22036" /db_xref="EnsemblGenomes-Tr:CCQ48599" /db_xref="UniProtKB/TrEMBL:L8ECR0" /translation="MTMLFLLGAVCTYSVLIGFVLKGISNKSV*" /label="fbpC CDS" gene complement(1909432..1909521) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /label="fbpC gene" promotor_-10 complement(1909549..1909568) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1909570) /Source="Nicolas_upshifts" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1909583..1909590) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1909592..1910098) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /EC_number="2.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 7726551, 8396117, 19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 7726551, 8396117, 19465653; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkylpyrone methyltransferase (polyketide synthesis)" /protein_id="NP_390086.1" /db_xref="EnsemblGenomes-Gn:BSU22040" /db_xref="EnsemblGenomes-Tr:CAB14121" /db_xref="GOA:P54158" /db_xref="InterPro:IPR007269" /db_xref="SubtiList:BG11603" /db_xref="UniProtKB/Swiss-Prot:P54158" /translation="MFWLLIAILIVQRAAEMAVARQNEQKVKKQGAIEFGESHYPYII TMHILFFLSLIAEVLLMNKQPSSWWLGIAAVILSVQIVRYWALCSLGAYWNTKILVVP GVELVKKGPYKWMKHPNYAVVILEILLIPLLYQAYVTMCLFSIFNAVLLSVRIRAEDK ALQEYSVK*" /label="bpsB CDS" gene complement(1909592..1910098) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /label="bpsB gene" CDS complement(1910102..1911199) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /EC_number="2.3.1.-" /function="15.10: Adaptations to atypical conditions" /experiment="publication(s) with functional evidences, PMID:19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19465653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous alkylpyrone synthase BpsA (polyketide synthesis)" /protein_id="NP_390087.1" /db_xref="EnsemblGenomes-Gn:BSU22050" /db_xref="EnsemblGenomes-Tr:CAB14122" /db_xref="GOA:P54157" /db_xref="InterPro:IPR001099" /db_xref="InterPro:IPR011141" /db_xref="InterPro:IPR012328" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018088" /db_xref="SubtiList:BG11523" /db_xref="UniProtKB/Swiss-Prot:P54157" /translation="MAFILSIGTSLPAYNVNQEKAAEFARYMFQHSFKDIDRLLSSFK NGQIHSRQFVKPIEWYKEGHSFEEKNQIYIEETLKHSRAAVRECLSHPEFFQEAIPYE KVEAVFFVSSTGLSTPSIEARLMNELPFSPYTKRIPIWGLGCAGGASGLARAAEYCKA YPEAFVLVISAELCSLTFQPEDKTKSNLIGTSLFGDGIAAALLCGEKADRRVSKLKLA PKIMDAQSVLMKQSEDVMGWDFTDQGFKVIFSRDIPTLVEKWLKTNVQIFLDKHKLSF HDISVFLAHPGGKKVIDAYIKSLGLSSEKLSSAQSILQKHGNMSSATILYVIKDHLQN GHKKEAERGLIGALGPGFSSELLLFSWEKGA*" /label="bpsA CDS" gene complement(1910102..1911199) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /label="bpsA gene" promotor_-10 complement(1911217..1911228) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1911220) /Source="Nicolas_upshifts" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1911243..1911249) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1911273..1912589) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098051, 12923093, 15549109, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098051, 12923093, 15549109, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xanthine permease" /protein_id="NP_390088.1" /db_xref="EnsemblGenomes-Gn:BSU22060" /db_xref="EnsemblGenomes-Tr:CAB14123" /db_xref="GOA:P42086" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG11080" /db_xref="UniProtKB/Swiss-Prot:P42086" /translation="MRNGFGKTLSLGIQHVLAMYAGAIVVPLIVGKAMGLTVEQLTYL VSIDIFMCGVATLLQVWSNRFFGIGLPVVLGCTFTAVSPMIAIGSEYGVSTVYGSIIA SGILVILISFFFGKLVSFFPPVVTGSVVTIIGITLMPVAMNNMAGGEGSADFGDLSNL ALAFTVLSIIVLLYRFTKGFIKSVSILIGILIGTFIAYFMGKVQFDNVSDAAVVQMIQ PFYFGAPSFHAAPIITMSIVAIVSLVESTGVYFALGDLTNRRLTEIDLSKGYRAEGLA VLLGGIFNAFPYTAFSQNVGLVQLTGIKKNAVIVVTGVILMAFGLFPKIAAFTTIIPS AVLGGAMVAMFGMVIAYGIKMLSRIDFAKQENLLIVACSVGLGLGVTVVPDIFKQLPS ALTLLTTNGIVAGSFTAVVLNIVYNVFSKAKKIEQEADLAEQKTAV*" /label="pbuX CDS" gene complement(1911273..1912589) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /label="pbuX gene" downshifts complement(1911286) /Source="Nicolas_upshifts" /id="D1156" /incds=0 /nref=177 /ntot=215 /MaxReadThrough="1.81377" /MaxDrop="6.3089" /score="32.8866099" /energy="-9" /TU="U1733" /idTUdmin="U1732" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1912586..1913170) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /EC_number="2.4.2.22" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12923093, 15549109, 19381559, 20108980, 20200045" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15549109, 19381559, 20108980, 20200045; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine phosphoribosyltransferase" /protein_id="NP_390089.1" /db_xref="EnsemblGenomes-Gn:BSU22070" /db_xref="EnsemblGenomes-Tr:CAB14124" /db_xref="GOA:P42085" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010079" /db_xref="InterPro:IPR029057" /db_xref="PDB:1Y0B" /db_xref="PDB:2FXV" /db_xref="SubtiList:BG11079" /db_xref="UniProtKB/Swiss-Prot:P42085" /translation="MEALKRKIEEEGVVLSDQVLKVDSFLNHQIDPLLMQRIGDEFAS RFAKDGITKIVTIESSGIAPAVMTGLKLGVPVVFARKHKSLTLTDNLLTASVYSFTKQ TESQIAVSGTHLSDQDHVLIIDDFLANGQAAHGLVSIVKQAGASIAGIGIVIEKSFQP GRDELVKLGYRVESLARIQSLEEGKVSFVQEVHS*" /label="xpt CDS" gene complement(1912586..1913170) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /label="xpt gene" misc_RNA complement(1913259..1913359) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswA RNA" gene complement(1913259..1913359) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /label="gswA gene" downshifts complement(1913266) /Source="Nicolas_upshifts" /id="D1157" /incds=0 /nref=8 /ntot=35 /MaxReadThrough="6.97435" /MaxDrop="3.25" /score="36.5247418" /energy="-19.2" /TU="U1732,U1733" /idTUdmin="U1734" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" S_feature complement(1913360..1913500) /Source="Nicolas_S_feature" /locus_tag="new_2320214_2320354_c" /HighExp="dia15, BT, dia5, Diami, C90, LBGtran, Lbtran, Gly, SMMPr, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.291, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S835" CDS complement(1913501..1915006) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /EC_number="3.4.17.19" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7765282, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="metal-dependent carboxypeptidase" /protein_id="NP_390090.1" /db_xref="EnsemblGenomes-Gn:BSU22080" /db_xref="EnsemblGenomes-Tr:CAB14125" /db_xref="GOA:P50848" /db_xref="InterPro:IPR001333" /db_xref="PDB:3HQ2" /db_xref="SubtiList:BG11458" /db_xref="UniProtKB/Swiss-Prot:P50848" /translation="MEIHTYEKEFFDLLKRISHYSEAVALMHWDSRTGAPKNGSEDRA ESIGQLSTDIFNIQTSDRMKELIDVLYERFDDLSEDTKKAVELAKKEYEENKKIPEAE YKEYVILCSKAETAWEEAKGKSDFSLFSPYLEQLIEFNKRFITYWGYQEHPYDALLDL FEPGVTVKVLDQLFAELKEAIIPLVKQVTASGNKPDTSFITKAFPKEKQKELSLYFLQ ELGYDFDGGRLDETVHPFATTLNRGDVRVTTRYDEKDFRTAIFGTIHECGHAIYEQNI DEALSGTNLSDGASMGIHESQSLFYENFIGRNKHFWTPYYKKIQEASPVQFKDISLDD FVRAINESKPSFIRVEADELTYPLHIIIRYEIEKAIFSNEVSVEDLPSLWNQKYQDYL GITPQTDAEGILQDVHWAGGDFGYFPSYALGYMYAAQLKQKMLEDLPEFDALLERGEF HPIKQWLTEKVHIHGKRKKPLDIIKDATGEELNVRYLIDYLSNKYSNLYLL*" /label="ypwA CDS" gene complement(1913501..1915006) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /label="ypwA gene" promotor_no_box complement(1914942..1915042) /Source="Nicolas_upshift_promotors" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1914982) /Source="Nicolas_upshifts" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" downshifts 1914994 /Source="Nicolas_upshifts" /id="D1158" /incds=0 /nref=4 /ntot=78 /MaxReadThrough="1.34397" /MaxDrop="3.87399" /score="12.6922524" /energy="-13.3" /TU="NA" /idTUdmin="U1735" /TUdmin="-5588" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1915032..1915051) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1915048) /Source="Nicolas_upshifts" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1915065..1915072) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1915118..1916110) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 9846747; Product type t: transporter" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate permease" /protein_id="NP_390091.1" /db_xref="EnsemblGenomes-Gn:BSU22090" /db_xref="EnsemblGenomes-Tr:CAB14126" /db_xref="GOA:P50847" /db_xref="InterPro:IPR004684" /db_xref="InterPro:IPR018395" /db_xref="SubtiList:BG11399" /db_xref="UniProtKB/Swiss-Prot:P50847" /translation="MKIKATIERVPGGMMIIPLFLGAALNTFAPGTAEFFGGFTGALI TGTLPILGVFIFCVGATIDFRSSGYIARKGITLLLGKIGFAALLGVIAAQFIPDDGIQ SGFFAGLSVLAIVAVMNETNGGLYLALMNHMGRKEDAGAFAFISTESGPFMTMVTFGV TGLAAFPWETLAATVIPFLLGCILGNLDHDLRDLFSKVVPAIIPFFAFSLGNTLNFGM LIQSGLLGIFIGVSVVILSGSSLFLLDRFIARGDGVAGVAASSTAGAAVAVPYALAEA NASFAPVAESATAIIATSVIVTSLLTPLATVWVDKKIKQKKRRTPPPKNQMTIN*" /label="kdgT CDS" gene complement(1915118..1916110) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /label="kdgT gene" downshifts complement(1915136) /Source="Nicolas_upshifts" /id="D1159" /incds=0 /nref=15 /ntot=59 /MaxReadThrough="3.32882" /MaxDrop="5.85236" /score="36.5247418" /energy="-19.2" /TU="NA" /idTUdmin="U1734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1916155..1916745) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /EC_number="4.1.2.14" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate-6-phosphate aldolase" /protein_id="NP_390092.1" /db_xref="EnsemblGenomes-Gn:BSU22100" /db_xref="EnsemblGenomes-Tr:CAB14127" /db_xref="GOA:P50846" /db_xref="InterPro:IPR000887" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031338" /db_xref="SubtiList:BG11396" /db_xref="UniProtKB/Swiss-Prot:P50846" /translation="MESKVVENRLKEAKLIAVIRSKDKQEACQQIESLLDKGIRAVEV TYTTPGASDIIESFRNREDILIGAGTVISAQQAGEAAKAGAQFIVSPGFSADLAEHLS FVKTHYIPGVLTPSEIMEALTFGFTTLKLFPSGVFGIPFMKNLAGPFPQVTFIPTGGI HPSEVPDWLRAGAGAVGVGSQLGSCSKEDLQAVFQV*" /label="kdgA CDS" gene complement(1916155..1916745) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /label="kdgA gene" CDS complement(1916747..1917721) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /EC_number="2.7.1.45" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143, 15039578; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate kinase" /protein_id="NP_390093.1" /db_xref="EnsemblGenomes-Gn:BSU22110" /db_xref="EnsemblGenomes-Tr:CAB14128" /db_xref="GOA:P50845" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG11397" /db_xref="UniProtKB/Swiss-Prot:P50845" /translation="MKLDAVTFGESMAMFYANEYGGLHEVSTFSKGLAGAESNVACGL ARLGFRMGWMSKVGNDQLGTFILQELKKEGVDVSRVIRSQDENPTGLLLKSKVKEGDP QVTYYRKNSAASTLTTAEYPRDYFQCAGHLHVTGIPPALSAEMKDFTYHVMNDMRNAG KTISFDPNVRPSLWPDQATMVHTINDLAGLADWFFPGIAEGELLTGEKTPEGIADYYL KKGASFVAIKLGKEGAYFKTGTSEGFLEGCRVDRVVDTVGAGDGFAVGVISGILDGLS YKDAVQRGNAIGALQVQAPGDMDGLPTREKLASFLSAQRTVHQKKGDY*" /label="kdgK CDS" gene complement(1916747..1917721) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /label="kdgK gene" CDS complement(1917759..1918778) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9846747, 15223311, 17322190, 28040177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9846747, 15223311, 17322190, 28040177; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the Kdg operon (KdgR-galacturonate)" /protein_id="NP_390094.1" /db_xref="EnsemblGenomes-Gn:BSU22120" /db_xref="EnsemblGenomes-Tr:CAB14129" /db_xref="GOA:P50844" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG11398" /db_xref="UniProtKB/Swiss-Prot:P50844" /translation="MKKKTTGHTTIKDVAECAGVSKSTVSRYINGKIDAISPEKVKNI KKAIAELNYRPSKMAQGLKIKKSKLIGFVVADITNPFSVAAFRGVEEVCDQYGYSIMV CNTDNSPEKEREMLLKLEAHSVEGLILNATGENKDVLRAFAEQQIPTILIDRKLPDLK LDTVTTDNRWITKEILQKVYSKGYTDVALFTEPISSISPRAERAAVYQEMASVQNVNG LVRLHEIDVKDKEQLKAELRSFHKEMPEQKKAILALNGLIMLKIISCMEELGLRIPQD IGIAGFDDTEWYKLIGPGITTIAQPSHDMGRTAMERVLKRIEGDKGAPQTIELEAKVI MRKSL*" /label="kdgR CDS" gene complement(1917759..1918778) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /label="kdgR gene" promotor_-10 complement(1918826..1918845) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1918836) /Source="Nicolas_upshifts" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1918857..1918864) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1918899..1918906 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1918920..1918999 /Source="Nicolas_S_feature" /locus_tag="new_2325774_2325853" /HighExp="HiTm, Heat, nit, LBGstat, ferm, T-0.40H, HiOs, T1.30H, MG 150, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S836" upshifts 1918920 /Source="Nicolas_upshifts" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1918921..1918940 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1919000..1919827 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /EC_number="5.3.1.17" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 23437267, 27227414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase" /protein_id="NP_390095.1" /db_xref="EnsemblGenomes-Gn:BSU22130" /db_xref="EnsemblGenomes-Tr:CAB14130" /db_xref="GOA:P50843" /db_xref="InterPro:IPR007045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR027449" /db_xref="SubtiList:BG11401" /db_xref="UniProtKB/Swiss-Prot:P50843" /translation="MENRYSVHPEQVKRFTTEELRSHFLMDSLFTENKLTMYYSHEDR VVIGGAAPGQSELKLDAGDFLKTDFFLERREIGIINVGQPGAVRVGDDEYVLQTKDFL YIGMGNQDVSFSSLNGEKAKFYFVSACAHKSYPTQKAALSELTPDRLGDDAASNVRSL YKVIHQDGIKSCQLMMGITMLDQNNNWNTMPAHVHDRRMEAYLYLDLEKDSKVFHFMG QPDETRHLVVGNEQAVLSPAWSIHSGAGTSNYSFVWAMAGENYTFTDMDLIPMDGLK* " /label="kduI CDS" gene 1919000..1919827 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /label="kduI gene" CDS 1919829..1920593 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /EC_number="1.1.1.127" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 24509771, 27028675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate oxidoreductase" /protein_id="NP_390096.1" /db_xref="EnsemblGenomes-Gn:BSU22140" /db_xref="EnsemblGenomes-Tr:CAB14131" /db_xref="GOA:P50842" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011286" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11400" /db_xref="UniProtKB/Swiss-Prot:P50842" /translation="MGYLHDAFSLKGKTALVTGPGTGIGQGIAKALAGAGADIIGTSH TSSLSETQQLVEQEGRIFTSFTLDMSKPEAIKDSAAELFENRQIDILVNNAGIIHREK AEDFPEENWQHVLNVNLNSLFILTQLAGRHMLKRGHGKIINIASLLSFQGGILVPAYT ASKHAVAGLTKSFANEWAASGIQVNAIAPGYISTANTKPIRDDEKRNEDILKRIPAGR WGQADDIGGTAVFLASRASDYVNGHILAVDGGWLSR*" /label="kduD CDS" gene 1919829..1920593 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /label="kduD gene" downshifts 1920582 /Source="Nicolas_upshifts" /id="D1160" /incds=0 /nref=12 /ntot=160 /MaxReadThrough="0.66029" /MaxDrop="3.56178" /score="23.0070487" /energy="-12.3" /TU="NA" /idTUdmin="U1735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1920624) /Source="Nicolas_upshifts" /id="D1161" /incds=0 /nref=28 /ntot=225 /MaxReadThrough="1.88107" /MaxDrop="5.27501" /score="35.5168663" /energy="-12.3" /TU="NA" /idTUdmin="U1736" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(1920634..1922559) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /EC_number="3.6.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8385320, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent helicase" /protein_id="NP_390097.1" /db_xref="EnsemblGenomes-Gn:BSU22150" /db_xref="EnsemblGenomes-Tr:CAB14132" /db_xref="GOA:P50831" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11457" /db_xref="UniProtKB/Swiss-Prot:P50831" /translation="MTTSRLPFSLTKTKNFYEELNNWIGDVFYDILPEKGFDLRDEQV FMAFQLERAFKEKKVMFAEAGVGTGKTLVYLLFAISYARYVGKPAIIACADETLIEQL VKKEGDISKLAEHLDLKIDTRLSKSHEQYLCLKKLEKTMQRSDDDKWLDLYESLPSFV HESQAMQRFYPYGDRKQYANLSNEEWSDVSYDSFQDCLTCDMRHRCGLTLSRDYYRKS TDLIICSHDFYMEHVWTEESRKREGQLPLLPDHSAVVFDEGHLLEFAAQKALTYRVKQ STLELFLERLLQNDIREEFAELIEDALLANDEFFYVLSEESKEVAGSHRLEIKNDHRV KKAADELCRLLDKIGEALVFESEMYTIDQYELSVVEEYVEQMAYSLSLYQKDAISWLE KKEAESTFVVMPRTVAEVLGEKVFSKKIPYIFSSATLSEGGSFDYIADSLGIHDYLSL TVDSPYDYDEQMSINLYAKTDMDAEQKTAETIETIKRYKGRTLVLFPSFEELNEFKEL SAAWELPYPIFFEGDEEISSLVEKFQEEEETVLCSVHLWEGLDIPGDALKNVTIWSLP FPPHDPVFTAKRNGAKKDPFEEVDLPYMLLRVRQGIGRLIRSNQDSGSIHIYAGGENE RIIDEVKKVLPVEPHMM*" /label="ypvA CDS" gene complement(1920634..1922559) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /label="ypvA gene" promotor_-10 complement(1922590..1922609) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1922594) /Source="Nicolas_upshifts" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1922596..1922660) /Source="Nicolas_S_feature" /locus_tag="new_2329450_2329514_c" /HighExp="S3, S4, S8, S7, LoTm, S5, S6, BT, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S837" promotor_-35 complement(1922624..1922628) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1922661..1922852) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390098.1" /db_xref="EnsemblGenomes-Gn:BSU22160" /db_xref="EnsemblGenomes-Tr:CAB14133" /db_xref="SubtiList:BG11456" /db_xref="UniProtKB/Swiss-Prot:P50841" /translation="MLNSEHFNLIQRALDATANELKELGTDSSPSVISHAQTDLEKAV EHIYSTDHPFLSSHVINRK*" /label="yptA CDS" gene complement(1922661..1922852) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /label="yptA gene" promotor_-10 complement(1922871..1922889) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1922880) /Source="Nicolas_upshifts" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1922882..1923187) /Source="Nicolas_S_feature" /locus_tag="new_2329736_2330041_c" /HighExp="Cold, G135, G180, C30, G150, Oxctl, Paraq, H2O2, LBGstat, LPh" /AntisenseName="ypzG" /AntisenseCor="-0.39420155633160697" /AntisenseRegPval="-10.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S838" promotor_-35 complement(1922905..1922910) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1922919..1922925 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1922940..1922951 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1922949 /Source="Nicolas_upshifts" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="upshifts" CDS 1923016..1923168 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097754.1" /db_xref="EnsemblGenomes-Gn:BSU22169" /db_xref="EnsemblGenomes-Tr:CAX52653" /db_xref="InterPro:IPR025413" /db_xref="UniProtKB/Swiss-Prot:C0H444" /translation="MSYRNRLDQHSELFHHNWTRPKRSKSQVNGHTEMSQTNIILRSN AKAHRW*" /label="ypzG CDS" gene 1923016..1923168 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /label="ypzG gene" downshifts 1923178 /Source="Nicolas_upshifts" /id="D1162" /incds=0 /nref=35 /ntot=65 /MaxReadThrough="1.2837" /MaxDrop="7.64655" /score="-9.36260071" /energy="-16.3" /TU="NA" /idTUdmin="U1738" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1923221..1924378) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /EC_number="2.1.1.264" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22210896, 22362734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="m(7)G2069 methylase of 23S rRNA" /protein_id="NP_390099.1" /db_xref="EnsemblGenomes-Gn:BSU22170" /db_xref="EnsemblGenomes-Tr:CAB14134" /db_xref="GOA:P50840" /db_xref="InterPro:IPR000241" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11455" /db_xref="UniProtKB/Swiss-Prot:P50840" /translation="MKKYTLIATAPMGIEAVVAKEVRDLGYECKVDNGKVIFEGDALA ICRANLWLRTADRIKVQVASFKAKTFDELFEKTKAINWRSFIPENGKFPVIGKSVKST LASVPDCQRIVKKAIVEKLKLQSGKANDWIEETGAEYKVEISLLKDQALITLDSSGTG LHKRGYRVDQGGAPIKETLAAALVQLTNWTPDRPFVDPFCGSGTIAIEAALIGQNIAP GFNRDFVSEDWEWIGKDLWNKARLEVEEKANYDQPLTIFASDIDHRMVQIAKENAEEA GLGDLIQFKQMQVKDFTTNLEFGVIVGNPPYGERLGEKKAVEQMYKEMGQAFEPLDTW SVYMLTSNENFEEAYGRKATKKRKLFNGFIKTDYYQYWSKVRPQRKKTENA*" /label="rlmKB CDS" gene complement(1923221..1924378) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /label="rlmKB gene" downshifts complement(1923232) /Source="Nicolas_upshifts" /id="D1163" /incds=0 /nref=86 /ntot=240 /MaxReadThrough="4.31441" /MaxDrop="4.58268" /score="14.6684819" /energy="-6.2" /TU="U1739" /idTUdmin="U1740" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(1924466..1924866) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /product="RNA component of ribonuclease P (RNase P) (catalytic subunit, ribozyme)" /experiment="publication(s) with functional evidences, PMID:1699929, 16980484, 17919279, 22448220" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1699929, 16980484, 17919279, 22448220; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rnpB RNA" gene complement(1924466..1924866) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /label="rnpB gene" downshifts complement(1924476) /Source="Nicolas_upshifts" /id="D1164" /incds=0 /nref=200 /ntot=276 /MaxReadThrough="6.17541" /MaxDrop="7.4677" /score="0.20729905" /energy="-10.4" /TU="U1739,U1740" /idTUdmin="U1742" /TUdmin=406 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1924863..1924882) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1924881) /Source="Nicolas_upshifts" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1924897..1924903) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1924925..1925221) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:18363795, 18776011, 19429628, 25845974, 27257764" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18363795, 18776011, 19429628, 25845974, 27257764; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell division protein" /protein_id="NP_390100.1" /db_xref="EnsemblGenomes-Gn:BSU22180" /db_xref="EnsemblGenomes-Tr:CAB14135" /db_xref="GOA:P0CI74" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR011229" /db_xref="InterPro:IPR019933" /db_xref="PDB:4UG3" /db_xref="PDB:5AN5" /db_xref="SubtiList:BG11454" /db_xref="UniProtKB/Swiss-Prot:P0CI74" /translation="MLADKVKLSAKEILEKEFKTGVRGYKQEDVDKFLDMIIKDYETF HQEIEELQQENLQLKKQLEEASKKQPVQSNTTNFDILKRLSNLEKHVFGSKLYD*" /label="gpsB CDS" gene complement(1924925..1925221) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /label="gpsB gene" promotor_-10 complement(1925246..1925265) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1925256) /Source="Nicolas_upshifts" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1925279..1925286) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1925299..1925928) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390101.2" /db_xref="EnsemblGenomes-Gn:BSU22190" /db_xref="EnsemblGenomes-Tr:CAB14136" /db_xref="InterPro:IPR010697" /db_xref="PDB:2NX2" /db_xref="SubtiList:BG11453" /db_xref="UniProtKB/Swiss-Prot:P50838" /translation="MENVQLDGVNNAAQQMGPTGAPFFKAGEMMKVLAITGYKPFELG IFKQDDKALYYIKKAIKNRLIAFLDEGLEWILISGQLGVELWAAEAAYDLQEEYPDLK VAVITPFYEQEKNWKEPNKEQYEAVLAQADYEASLTHRPYESPLQFKQKNQFFIDKSD GLLLLYDPEKEGSPKYMLGTAEKRREQDGYPIYFITMDDLRVTVEEDSY*" /label="ypsA CDS" gene complement(1925299..1925928) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /label="ypsA gene" downshifts complement(1925894) /Source="Nicolas_upshifts" /id="D1165" /incds=0 /nref=37 /ntot=160 /MaxReadThrough="5.74028" /MaxDrop="8.12374" /score="7.18626302" /energy="-9.8" /TU="U1741,U1742" /idTUdmin="U1744" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1925930..1926157) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2821284, 10075739, 10400595, 1518043, 1691789, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2821284, 10075739, 10400595, 1518043, 1691789, 19933362; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner)" /protein_id="NP_390102.1" /db_xref="EnsemblGenomes-Gn:BSU22200" /db_xref="EnsemblGenomes-Tr:CAB14137" /db_xref="GOA:P07791" /db_xref="InterPro:IPR020108" /db_xref="SubtiList:BG10493" /db_xref="UniProtKB/Swiss-Prot:P07791" /translation="MHHCRPHMMAPIVHPTHCCEHHTFSKTIVPHIHPQHTTNVNHQH FQHVHYFPHTFSNVDPATHQHFQAGKPCCDY*" /label="cotD CDS" gene complement(1925930..1926157) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /label="cotD gene" promotor_-10 complement(1926185..1926204) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-10" upshifts complement(1926200) /Source="Nicolas_upshifts" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="upshifts" S_feature complement(1926202..1926356) /Source="Nicolas_S_feature" /locus_tag="new_2333056_2333210_c" /HighExp="LBGexp, dia15, Paraq, H2O2, Heat, G135, UNK1, Lbexp, BMM, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.808141" /TUshortSig="SigA, Sig-, SigA, SigA" /TUshortPSig="1, 0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S839" promotor_-35 complement(1926218..1926226) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-35" CDS complement(1926241..1926369) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513975.1" /translation="MTLVIFKGRVGMYKGVFYLFFVVVFLIAFVFSNFKDSLIAHF*" /label="conserved protein of unknown function CDS" gene complement(1926241..1926369) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /label="gene" upshifts complement(1926356) /Source="Nicolas_upshifts" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" S_feature complement(1926358..1926469) /Source="Nicolas_S_feature" /locus_tag="new_2333212_2333323_c" /HighExp="Sw, M40t90, Etha, Salt, M40t45, H2O2, S8, S6, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S840" promotor_-10 complement(1926359..1926378) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" promotor_-35 complement(1926394..1926398) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1926470..1927711) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23249255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding enzyme" /protein_id="NP_390103.1" /db_xref="EnsemblGenomes-Gn:BSU22210" /db_xref="EnsemblGenomes-Tr:CAB14138" /db_xref="GOA:P50837" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11452" /db_xref="UniProtKB/Swiss-Prot:P50837" /translation="MSLKGKLQRMKKHMALDEGEQKIEAGKQENHFDDIPFLEEWEAF GMKPFIFEDEYCLIREVEYPLSHRHGLYSFSELEEVITLWNQSGLSHTLSAKGYNKNN LFFFDTETTGLGGGAGNTIFLLGHARVYEDRVTVKQHLLPKPGNEVALYQSFLSEVDI TSLVTYNGKAFDWPQVKTRHTLIRDRLPKLPEFGHFDLLHGARRLWKHKMDRVSLGTV EKEELGIRRLEDTPGYLAPMLYFHFIKAQEPDLLKGVLHHNEMDVLSLISLYIHMSKK ILSESHAPKEHSEAYAMAKWFMAHKETDQAIKQLERLIEKSFEDQDSARLDLSLLYKK QNRLEEAVPLWEKLSRSQNQKCRYAAVIELAKYFEHKKKEFGKALQVAEQSLSDAACL SEKETEKLHVRIARLKRKYSS*" /label="yprB CDS" gene complement(1926470..1927711) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /label="yprB gene" promotor_-10 complement(1927425..1927443) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-10" upshifts complement(1927434) /Source="Nicolas_upshifts" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="upshifts" promotor_-35 complement(1927458..1927465) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-35" CDS complement(1927727..1929976) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /EC_number="3.6.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_390104.1" /db_xref="EnsemblGenomes-Gn:BSU22220" /db_xref="EnsemblGenomes-Tr:CAB14139" /db_xref="GOA:P50830" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018973" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11451" /db_xref="UniProtKB/Swiss-Prot:P50830" /translation="MKKKSLTELISDLKGNENVVNWHEIEPREAKTRPMPESIDERIK AALSKRGIDELYTHQYSAFQYVQKGESIVTVTPTASGKTLCYNLPVLQSIAQDETNRA LYLFPTKALAQDQKSELNEIIDEMGIDIKSFTYDGDTSPAIRQKVRKAGHIVITNPDM LHSAILPHHTKWVSLFENLKYIVIDELHTYRGVFGSHVANVIRRLKRICRFYGSDPVF ICTSATIANPKELGEQLTGKPMRLVDDNGAPSGRKHFVFYNPPIVNKPLNIRRSATAE VNELAKEFLKNKVQTIVFARSRVRVEIILSHIQELVKKEIGTKSIRGYRGGYLPKERR EIERGLREGDILGVVSTNALELGVDIGQLQVCVMTGYPGSVASAWQQAGRAGRRHGES LIIMVANSTPIDQYIVRHPEYFFNRSPESARINPENLIILVDHLKCAAYELPFRADEE FGAMEVSDILEYLQEEAVLHRNGERYHWASESFPASNISLRSASQENVVIVDQSDIAN VRIIGEMDRFSAMTLLHDEAIYLHEGVQYQVEKLDWDHKKAYVRKVDVEYYTDANLAV QLKVLEIDKTKEKSRTSLHYGDVTVNALPTIFKKIKMTTFENIGSGPIHLPEEELHTS AAWLEIKTADEDIGEKTLEQLLLGISNVLQHIVPVYIMCDRNDVHVVSQIKAAHTGLP TIFLYDHYPGGIGLAEEVFKRFSDINEAAKQLITHCPCHDGCPSCIGTEIEGIKAKER ILQLLDQMS*" /label="yprA CDS" gene complement(1927727..1929976) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /label="yprA gene" promotor_-10 complement(1929992..1930011) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1930008) /Source="Nicolas_upshifts" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1930025..1930031) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1930079..1930585) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10627040, 28731580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase system enzyme IIA component" /protein_id="NP_390105.1" /db_xref="EnsemblGenomes-Gn:BSU22230" /db_xref="EnsemblGenomes-Tr:CAB14140" /db_xref="GOA:P50829" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG11450" /db_xref="UniProtKB/Swiss-Prot:P50829" /translation="MLKKLFGMGKIQEKVTEEVIYSPADGTVMDLSDVPDPVFSQKMM GEGIAVEPSSGEIVSPAEGEVIQIFHTKHAVGIRTRSGIELLIHVGLETVNMNGEGFT AHIKEGDKVKVGDPLITCDLELIKEKASSTVIPIVIMNGEAVGSMVSAGEKAARKGES KLFTIKAK*" /label="ypqE CDS" gene complement(1930079..1930585) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /label="ypqE gene" downshifts complement(1930102) /Source="Nicolas_upshifts" /id="D1166" /incds=0 /nref=88 /ntot=236 /MaxReadThrough="4.55156" /MaxDrop="6.1724" /score="32.5355561" /energy="-10.2" /TU="U1745" /idTUdmin="U1747" /TUdmin=808 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1930629..1930648) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1930646) /Source="Nicolas_upshifts" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1930662..1930669) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" promotor_-35 1930667..1930676 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1930690..1930709 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1930702 /Source="Nicolas_upshifts" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="upshifts" CDS 1930723..1931142 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_390106.1" /db_xref="EnsemblGenomes-Gn:BSU22240" /db_xref="EnsemblGenomes-Tr:CAB14141" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11449" /db_xref="UniProtKB/Swiss-Prot:P50836" /translation="MEFHDDKKNELQKKEEIITEAIDTLFQSSAFGNLINGFQNLINS SLKDVQTTIHVRERDTGLYIDITIPATFRDGEIVVDVKSRYLHVTLQEKQKHQNEATF TSMTRTVQLPYEVRQEDMETSWNEQTMTLFFPKNKHE*" /label="ypqA CDS" gene 1930723..1931142 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /label="ypqA gene" S_feature 1931143..1931293 /Source="Nicolas_S_feature" /locus_tag="new_2337997_2338147" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, nit" /AntisenseName="yppG" /AntisenseCor="0.95679380325708796" /AntisenseRegPval="-144.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S841" CDS complement(1931163..1931540) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein; methionine-glutamine-rich protein" /protein_id="NP_390107.1" /db_xref="EnsemblGenomes-Gn:BSU22250" /db_xref="EnsemblGenomes-Tr:CAB14142" /db_xref="InterPro:IPR025555" /db_xref="SubtiList:BG11448" /db_xref="UniProtKB/Swiss-Prot:P50835" /translation="MNGSSRSYPRQMGYYYPQHMQGYYQQAAPGYLEQQLPQQHYGQQ DYYQPYAPIQPMPMQPPVFSNPYPIPRPNQQQPSQFQSIMSQFKKANGQFDFNKMMDT TGQVMSAMNQVGSLIKGFTSFFK*" /label="yppG CDS" gene complement(1931163..1931540) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /label="yppG gene" downshifts complement(1931196) /Source="Nicolas_upshifts" /id="D1167" /incds=0 /nref=10 /ntot=43 /MaxReadThrough="3.01854" /MaxDrop="4.7006" /score="0.85617333" /energy="-12.8" /TU="U1747" /idTUdmin="U1747" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature 1931538..1931683 /Source="Nicolas_S_feature" /locus_tag="new_2338392_2338537" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, C30" /AntisenseName="yppG" /AntisenseCor="0.96504903995490698" /AntisenseRegPval="-156.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S842" promotor_-10 complement(1931570..1931588) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1931589) /Source="Nicolas_upshifts" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1931602..1931611) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1931684..1931703 /Source="Nicolas_upshift_promotors" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1931685 /Source="Nicolas_upshifts" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1931728..1931916 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390108.1" /db_xref="EnsemblGenomes-Gn:BSU22260" /db_xref="EnsemblGenomes-Tr:CAB14143" /db_xref="InterPro:IPR025553" /db_xref="SubtiList:BG11447" /db_xref="UniProtKB/Swiss-Prot:P50834" /translation="MNVSYLSKRFAEMKKYETDCMNKLMDFAKFLYIQGHLSITEFRN SMKVLEANGAESPAYEMN*" /label="yppF CDS" gene 1931728..1931916 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /label="yppF gene" downshifts 1931932 /Source="Nicolas_upshifts" /id="D1168" /incds=0 /nref=112 /ntot=242 /MaxReadThrough="3.3677" /MaxDrop="5.69944" /score="0.283992322" /energy="-8.5" /TU="U1748" /idTUdmin="U1748" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" CDS complement(1931955..1932326) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390109.1" /db_xref="EnsemblGenomes-Gn:BSU22270" /db_xref="EnsemblGenomes-Tr:CAB14144" /db_xref="InterPro:IPR014913" /db_xref="InterPro:IPR023351" /db_xref="PDB:2HFI" /db_xref="PDB:2IM8" /db_xref="SubtiList:BG11446" /db_xref="UniProtKB/Swiss-Prot:P50833" /translation="MLSQTLLEMTEQMIEVAEKGADRYQEGKNSNHSYDFFETIKPAV EENDELAARWAEGALELIKVRRPKYVHKEQIEAVKDNFLELVLQSYVHHIHKKRFKDI TESVLYTLHAVKDEIAREDSR*" /label="yppE CDS" gene complement(1931955..1932326) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /label="yppE gene" downshifts complement(1931988) /Source="Nicolas_upshifts" /id="D1169" /incds=0 /nref=158 /ntot=245 /MaxReadThrough="1.04225" /MaxDrop="5.78413" /score="-2.77698308" /energy="-10.3" /TU="NA" /idTUdmin="U1749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1932338..1932357) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1932351) /Source="Nicolas_upshifts" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1932370..1932375) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1932372..1932617) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15687200; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390110.1" /db_xref="EnsemblGenomes-Gn:BSU22280" /db_xref="EnsemblGenomes-Tr:CAB14145" /db_xref="InterPro:IPR020252" /db_xref="SubtiList:BG11445" /db_xref="UniProtKB/Swiss-Prot:P50832" /translation="MSGYVCKTDILRMLSDIEDELTRAEQSLNHSVNALEAEMRETEN DRLSVLEEEIIDLHICINELYQSPEHRYAFEKVYRIG*" /label="yppD CDS" gene complement(1932372..1932617) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /label="yppD gene" promotor_-10 complement(1932643..1932661) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1932648) /Source="Nicolas_upshifts" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1932673..1932681) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1932767..1932773 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1932788..1932799 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1932795 /Source="Nicolas_upshifts" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="upshifts" CDS 1932816..1932920 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054585.1" /db_xref="EnsemblGenomes-Gn:BSU22290" /db_xref="EnsemblGenomes-Tr:CAE01459" /db_xref="GOA:Q7WY65" /db_xref="SubtiList:BG14177" /db_xref="UniProtKB/Swiss-Prot:Q7WY65" /translation="MKTRPKKAGQQKKTESKAIDSLDKKLGGPNRPST*" /label="sspM CDS" gene 1932816..1932920 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /label="sspM gene" downshifts 1932902 /Source="Nicolas_upshifts" /id="D1170" /incds=0 /nref=31 /ntot=49 /MaxReadThrough="1.6498" /MaxDrop="6.01285" /score="0.283992322" /energy="-8.5" /TU="NA" /idTUdmin="U1751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1932945..1933907) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390111.1" /db_xref="EnsemblGenomes-Gn:BSU22300" /db_xref="EnsemblGenomes-Tr:CAB14146" /db_xref="InterPro:IPR019658" /db_xref="SubtiList:BG10952" /db_xref="UniProtKB/Swiss-Prot:P39791" /translation="MNVQEQQAIRKLLSRIERQTKMKNADNISRTNAYKAFYDRHPEI KWSLLASFVSRNAGWSMTDLKGSLFQLGLRERQQKWFFLAYERANWLIFSDAYPQLLL YHWSKRVGKPLFHLLHVFGVSQFMSEEWTRFWHERNTERLMYALIINEQNTIQTPIIQ NPSFKKNVFDTIPFYLSDWFHFNTVIFPSSNGFFYGISVKRFSKAEERIRLGKQLSQL LFKPELFSSFYHFLHTVPHTGSRFDMEKMIGITKRTSPMLRTCYPELIHSLDGTKTDW FHGKIKKTFFRREELPKQIELTDWYLHKKRQLHALFAVEQWLKK*" /label="yppC CDS" gene complement(1932945..1933907) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /label="yppC gene" promotor_-35 1933075..1933084 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1933096..1933111 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1933096 /Source="Nicolas_upshifts" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1933100..1933435 /Source="Nicolas_S_feature" /locus_tag="new_2339954_2340289" /HighExp="T1.0H, T0.30H, T1.30H, H2O2, Paraq, LBGstat, T2.0H, T-0.40H, Salt, T2.30H" /AntisenseName="yppC" /AntisenseCor="-0.27690969451148201" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S843" promotor_-35 1933406..1933410 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1933426..1933445 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1933437..1933947 /Source="Nicolas_S_feature" /locus_tag="new_2340291_2340801" /HighExp="LBGstat, T1.0H, T1.30H, H2O2, T0.30H, Paraq, T2.0H, C30, G135, G180" /AntisenseName="yppC" /AntisenseCor="-0.312791370178301" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S844" upshifts 1933437 /Source="Nicolas_upshifts" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1933908..1934364) /Source="Nicolas_S_feature" /locus_tag="new_2340762_2341218_c" /HighExp="S8, S6, S7, S5, C30, G135, S4, BT, G180, Fru" /AntisenseName="recU" /AntisenseCor="-0.34780203121991599" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S845" CDS 1933948..1934568 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction resolvase" /protein_id="NP_390112.1" /db_xref="EnsemblGenomes-Gn:BSU22310" /db_xref="EnsemblGenomes-Tr:CAB14147" /db_xref="GOA:P39792" /db_xref="InterPro:IPR004612" /db_xref="InterPro:IPR011335" /db_xref="PDB:1RZN" /db_xref="PDB:1ZP7" /db_xref="PDB:5FDK" /db_xref="SubtiList:BG10953" /db_xref="UniProtKB/Swiss-Prot:P39792" /translation="MIRYPNGKTFQPKHSVSSQNSQKRAPSYSNRGMTLEDDLNETNK YYLTNQIAVIHKKPTPVQIVNVHYPKRSAAVIKEAYFKQSSTTDYNGIYKGRYIDFEA KETKNKTSFPLQNFHDHQIEHMKQVKAQDGICFVIISAFDQVYFLEADKLFYFWDRKE KNGRKSIRKDELEETAYPISLGYAPRIDYISIIEQLYFSPSSGAKG*" /label="recU CDS" gene 1933948..1934568 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /label="recU gene" promotor_-10 complement(1934353..1934364) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1934364) /Source="Nicolas_upshifts" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1934379..1934385) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1934590..1937334 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /EC_number="2.4.1.129" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan glycosyltransferase (penicillin-binding proteins 1A and 1B)" /protein_id="NP_390113.1" /db_xref="EnsemblGenomes-Gn:BSU22320" /db_xref="EnsemblGenomes-Tr:CAB14148" /db_xref="GOA:P39793" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR003961" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036116" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10954" /db_xref="UniProtKB/Swiss-Prot:P39793" /translation="MSDQFNSREARRKANSKSSPSPKKGKKRKKGGLFKKTLFTLLIL FVLGVVGGAVTFAVMVSDAPSLDESKLKTPYSSTIYDKNGKEIAEVGAEKRTYVSIDE IPDVVKEAFIATEDARFYEHHGIDPVRIGGALVANFKDGFGAEGGSTITQQVVKNSLL SHQKTLKRKVQEVWLSIQLERNYSKDEILEMYLNRIYFSPRAYGIGKAAEEFFGVTDL SKLTVEQAATLAGMPQSPTAYNPVKNPDKAEKRRNIVLSLMKKQGFISDSQYNKAKKV AVKDEGVVSQKEYEKASTNKYSAFVEEVMKEIDEKSDVDPSADGLKIYTTLDTKAQDK LDELMDGDTVGFTEGMQGGVTLLDTKNGEVRAIGAGRNQPVGGFNYATQTKAQPGSTI KPILDYGPVIENKKWSTYEQIDDSAYTYSNGKPIRDWDRKYLGPISMRYALAQSRNIP ALKAFQAVGKDTAVDFANGLGLGLTKDNVTEAYSIGGFGGNDGVSPLTMAGAYSAFGN NGTYNEPHFVKSIEFNDGTKLDLTPKSKSAMSDYTAFMITDMLKTAVKTGTGQLAQVP GVEVAGKTGTTNFDDNEVKRYNIASGGARDSWFVGYTPQYTAAVWTGMGENEAGKKSL SAEEQKVAKRIFAQLIADVDDGSGSFEKPDSVVEATVEKGSNPAKLAGPNTPSDKKLT EYFVKGTAPSTVSKTYEKEEKEETAKLSGLNVKYDKDNQSLTLSWNYDGDATFAVKQS VDGGSYSEIQNSSAKEAVISGVQPGSVYKFEVTAVSDDGKSTASTSYEVPKAEDDEDK KDQQQTDDEKQDDEKTQDDTQTDDSQKDDGQTDQDQTDDSTNDQDKKQDNTNTNPSDN NNQDQSNDNDNDNSNNQDTSDGDSNSGKNDSTGSDTNKNKTDTSNKTQTNSSSIEKTN *" /label="ponA CDS" gene 1934590..1937334 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /label="ponA gene" downshifts complement(1937004) /Source="Nicolas_upshifts" /id="D1171" /incds=1 /nref=1 /ntot=77 /MaxReadThrough="1.95969" /MaxDrop="2.87717" /score="24.9960782" /energy="-11.3" /TU="NA" /idTUdmin="U1755" /TUdmin=418 /isTUend="FALSE" /label="downshifts" downshifts 1937320 /Source="Nicolas_upshifts" /id="D1172" /incds=0 /nref=243 /ntot=302 /MaxReadThrough="1.61976" /MaxDrop="7.42523" /score="24.2831363" /energy="-14.6" /TU="U1753" /idTUdmin="U1752" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1937410..1937904) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390114.1" /db_xref="EnsemblGenomes-Gn:BSU22330" /db_xref="EnsemblGenomes-Tr:CAB14149" /db_xref="SubtiList:BG10955" /db_xref="UniProtKB/Swiss-Prot:P39789" /translation="MTQAKEVLASYEQYLRSLGQKSSSDMKKTLQTNPVYFDFCTELQ GDLPWEDSGKYVPLLFEVWDDIKASLLPVFQTRKSRCDQNEMLKGIVCLLASLHWTAG EPVKSLDWQELREKSYPAKPINWAERVEFILLKPTQYHCFIQLDELITEMKKHFYKYH AMNR*" /label="ypoC CDS" gene complement(1937410..1937904) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /label="ypoC gene" downshifts complement(1937423) /Source="Nicolas_upshifts" /id="D1173" /incds=0 /nref=116 /ntot=222 /MaxReadThrough="2.50883" /MaxDrop="5.43593" /score="29.5358766" /energy="-11.6" /TU="NA" /idTUdmin="U1755" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1937901..1938560) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /EC_number="4.2.99.18" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9808040, 11160880, 12682299, 21954439, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9808040, 11160880, 12682299, 21954439, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease III, apurinic apyrimidic DNA lyase" /protein_id="NP_390115.1" /db_xref="EnsemblGenomes-Gn:BSU22340" /db_xref="EnsemblGenomes-Tr:CAB14150" /db_xref="GOA:P39788" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR004035" /db_xref="InterPro:IPR004036" /db_xref="InterPro:IPR005759" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG10956" /db_xref="UniProtKB/Swiss-Prot:P39788" /translation="MLNLKQIEFCLDKIGDMFPHAECELVHSNPFELVVAVALSAQCT DALVNRVTKTLFQKYKRPEDYLAVPLEELQQDIKSIGLYRNKAKNIQKLSKMIIEDYG GEVPRDRDELVKLPGVGRKTANVVVSVAFGVPAIAVDTHVERVSKRLGICRWKDSVLE VEKTLMRKVPKEDWSVTHHRLIFFGRYHCKAQSPRCAECPLLSLCREGQKRDKKGLVK R*" /label="nth CDS" gene complement(1937901..1938560) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /label="nth gene" CDS complement(1938579..1939277) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /function="16.9: Replicate" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-remodelling primosomal protein" /protein_id="NP_390116.1" /db_xref="EnsemblGenomes-Gn:BSU22350" /db_xref="EnsemblGenomes-Tr:CAB14151" /db_xref="GOA:P39787" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="PDB:2V79" /db_xref="SubtiList:BG10957" /db_xref="UniProtKB/Swiss-Prot:P39787" /translation="MKKQQFIDMQEQGTSTIPNLLLTHYKQLGLNETELILLLKIKMH LEKGSYFPTPNQLQEGMSISVEECTNRLRMFIQKGFLFIEECEDQNGIKFEKYSLQPL WGKLYEYIQLAQNQTQERKAEGEQKSLYTIFEEEFARPLSPLECETLAIWQDQDQHDA QLIKHALKEAVLSGKLSFRYIDRILFEWKKNGLKTVEQAKIHSQKFRRVQAKQNEPQK EYKRQVPFYNWLEQ*" /label="dnaD CDS" gene complement(1938579..1939277) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /label="dnaD gene" S_feature complement(1939278..1939369) /Source="Nicolas_S_feature" /locus_tag="new_2346132_2346223_c" /HighExp="LoTm, G180, Cold, G135, LBGstat, G150, C30, Etha, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S846" CDS complement(1939370..1940662) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /EC_number="6.1.1.22" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparaginyl-tRNA synthetase" /protein_id="NP_390117.1" /db_xref="EnsemblGenomes-Gn:BSU22360" /db_xref="EnsemblGenomes-Tr:CAB14152" /db_xref="GOA:P39772" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004522" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10958" /db_xref="UniProtKB/Swiss-Prot:P39772" /translation="MKTTINQVYKHVGEEVTIGAWVANKRSSGKIAFLQLRDGTGFIQ GVVVKAEVEESIFQTAKSVTQETSLYIKGIVKEDERSPLGYELAVTDIEVIHEATDYP ITPKEHGTEFLMDHRHLWLRSKRQHAIMKIRNEIIRATYEFFNNEGFVKVDPPILTGS APEGTTELFATKYFDEDAYLSQSGQLYMEAAAMALGKVFSFGPTFRAEKSKTKRHLIE FWMIEPEMAFVEFEENLQVQENYVSFIVQSVLKNCKIELNTLGRDTSKLEQIKAPFPR ITYDEAIEFLKEKGFDDIEWGDDFGAPHETAIAEHYDKPVFITRYPTSLKPFYMQPAS DREDVVLCADLIAPEGYGEIIGGSERIHDMELLESRLKEHGLDSDAYKWYAELRKYGS VPHSGFGLGLERTVAWISGAPHVRETIPFPRLLNRLYP*" /label="asnS CDS" gene complement(1939370..1940662) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /label="asnS gene" S_feature complement(1940663..1940724) /Source="Nicolas_S_feature" /locus_tag="new_2347517_2347578_c" /HighExp="LBGexp, dia0, Lbexp, G150, G180, LPh, C30, Oxctl, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S847" promotor_-10 complement(1940724..1940743) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1940724) /Source="Nicolas_upshifts" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1940758..1940765) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1940806..1941987) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /EC_number="2.6.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:418816, 12670965, 22740702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 418816, 12670965, 22740702; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anabolic oxaloacetate / glutamate aminotransferase" /protein_id="NP_390118.1" /db_xref="EnsemblGenomes-Gn:BSU22370" /db_xref="EnsemblGenomes-Tr:CAB14153" /db_xref="GOA:P53001" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11513" /db_xref="UniProtKB/Swiss-Prot:P53001" /translation="MKLAKRVSALTPSTTLAITAKAKELKAAGHDVIGLGAGEPDFNT PQHIIDAAVRSMNEGHTKYTPSGGLAELKNSIAEKFKRDQNIEYKPSQIIVCTGAKHA LYTLFQVILDEEDEVIIPTPYWVSYPEQVKLAGGKPVYVEGLEENHFKISPEQLKNAI TEKTKAIVINSPSNPTGVMYTEEELSALGEVCLEHDILIVSDEIYEKLTYGGKKHVSI AQLSDRLKEQTVIINGVSKSHSMTGWRIGYAAGSEDIIKAMTNLASHSTSNPTSIAQY GAIAAYNGPSEPLEEMREAFEHRLNTIYAKLIEIPGFSCVKPEGAFYLFPNAKEAAQS CGFKDVDEFVKALLEEEKVAIVPGSGFGSPENVRLSYATSLDLLEEAIERIKRFVEKH S*" /label="aspB CDS" gene complement(1940806..1941987) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /label="aspB gene" downshifts complement(1940810) /Source="Nicolas_upshifts" /id="D1174" /incds=0 /nref=48 /ntot=196 /MaxReadThrough="6.37268" /MaxDrop="4.0831" /score="5.04709675" /energy="-9.3" /TU="U1756,U1758,U1760,U1761,U1762" /idTUdmin="U1760" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(1942010..1942495) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /experiment="publication(s) with functional evidences, PMID:25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25954268; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="suppressor of tetracyclin sensitivity of an ezrAmutant" /protein_id="NP_390119.1" /db_xref="EnsemblGenomes-Gn:BSU22380" /db_xref="EnsemblGenomes-Tr:CAB14154" /db_xref="GOA:P54396" /db_xref="InterPro:IPR025711" /db_xref="PDB:2GU3" /db_xref="SubtiList:BG11502" /db_xref="UniProtKB/Swiss-Prot:P54396" /translation="MRKKALIFTVIFGIIFLAVLLVSASIYKSAMAQKEEGHEAAAAE AKKETDLAHVDQVETFVGKEKYYVVKGTDKKGTALYVWVPADKKAKILSKEAKEGISE DKAAKIIKDEGLVSKQKEVHLAREGNVLLWEVTYLDKEGQYSLSYVDFTTGKILKNIT P*" /label="tseB CDS" gene complement(1942010..1942495) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /label="tseB gene" promotor_-10 complement(1942443..1942462) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1942460) /Source="Nicolas_upshifts" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1942475..1942482) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1942504..1942674) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390120.1" /db_xref="EnsemblGenomes-Gn:BSU22390" /db_xref="EnsemblGenomes-Tr:CAB14155" /db_xref="InterPro:IPR012190" /db_xref="SubtiList:BG11501" /db_xref="UniProtKB/Swiss-Prot:P54395" /translation="MESKIEILSTINVEHSDDLYKIVDTLNRTLKRDNLMFGLALDEE NKNQAVFTIYRT*" /label="ypmA CDS" gene complement(1942504..1942674) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /label="ypmA gene" S_feature complement(1942675..1942746) /Source="Nicolas_S_feature" /locus_tag="new_2349529_2349600_c" /HighExp="H2O2, T0.30H, T0.0H, dia15, T-0.40H, T-1.10H, G135, T1.0H, G180, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.136042" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.85, 1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S848" promotor_-35 1942708..1942714 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1942729..1942748) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1942729..1942740 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1942736..1942810 /Source="Nicolas_S_feature" /locus_tag="new_2349590_2349664" /HighExp="S8, S6, S5, S7, nit, BT, G/S, Pyr, C30, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S849" upshifts 1942736 /Source="Nicolas_upshifts" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1942746) /Source="Nicolas_upshifts" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1942748..1942816) /Source="Nicolas_S_feature" /locus_tag="new_2349602_2349670_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, Salt, H2O2, T-1.10H, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S850" promotor_-35 complement(1942764..1942770) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1942780 /Source="Nicolas_upshifts" /id="D1175" /incds=0 /nref=8 /ntot=26 /MaxReadThrough="0.48859" /MaxDrop="6.02806" /score="18.4569945" /energy="-8.4" /TU="NA" /idTUdmin="U1757" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1942817..1945612) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8385320, 12060778, 17416902, 21546913, 22166102, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385320, 12060778, 17416902, 21546913, 22166102, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="damage inducible ATP-dependent 3'->5' nuclease" /protein_id="NP_390121.1" /db_xref="EnsemblGenomes-Gn:BSU22400" /db_xref="EnsemblGenomes-Tr:CAB14156" /db_xref="GOA:P54394" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006310" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11515" /db_xref="UniProtKB/Swiss-Prot:P54394" /translation="MNKQRFVVIDVETTGNSPKKGDKIIQIAAVVIENGQITERFSKY INPNKSIPAFIEQLTGISNQMVENEQPFEAVAEEVFQLLDGAYFVAHNIHFDLGFVKY ELHKAGFQLPDCEVLDTVELSRIVFPGFEGYKLTELSEELQLRHDQPHRADSDAEVTG LIFLEILEKLRQLPYPTLKQLRRLSQHFISDLTHLLDMFINENRHTEIPGYTRFSSFS VREPEAIDVRINEDENFSFEIESWEAGNEKALSELMPGYEKRDGQMMMMREVADAFAN REHALIEAPPGIGKTIGYLIPAALFAKKSKKPVIISTYSTLLQQQILTKDLPIVQDLF PFPVTAAILKGQSHYLCLYKFEQVLHEEDDNYDAVLTKAQLLVWLTETNTGDVAELNL PSGGKLLWDRLAYDDDSYKRSRSEHVIGFYERAKQIAMRSDLVITNHSLLLTDEGSHK KRLPESGTFIIDEAHHFERAASEHLGKRATYIELHTKLSRIGTLKEQGLLKKMRQLFQ RNSLPVDSFFELEEWLQHVQAESDAFFSSVHSFVKRRKPKEDLNRLVFKVNKESQDKS WSILTDGAERLCSMLTHLQQLFEAQSSLMEKHLKGMKSKTVFLADEYQRSMKGLQHYC QTLQKLFFGSDDDEAVWIEIDAKGAKNAVAIYAQPLEPGELLADQFFARKNSVVLTSA TLTVEGSFQFMIERLGLSDFFPRTMRIESPFSYDERMQVMIPKEMKSIQDTGQPEFIQ DTARYIELMAKEKQPKILVLFTSHDMLKKVHQELKHNMSASGIQLLAQGITGGSPGKL MKTFKTSNQAILLGTNHFWEGVDFPGDELTTVMIVRLPFRSPDHPLHAAKCELARKKG KNPFQTVSLPEAVLTFRQGIGRLLRSAGDKGTIIILDRRIKTAGYGRLFLDALPTTSV SEMTDSELEAYVAGEKE*" /label="dinG CDS" gene complement(1942817..1945612) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /label="dinG gene" promotor_-35 1943285..1943289 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1943286 /Source="Nicolas_upshifts" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1943291..1943295 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1943942..1943957) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(1943956) /Source="Nicolas_upshifts" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(1943970..1943979) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" S_feature complement(1945613..1945737) /Source="Nicolas_S_feature" /locus_tag="new_2352467_2352591_c" /HighExp="dia15, Diami, H2O2, Heat, LBGstat, C30, G180, G135, Oxctl, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S851" CDS complement(1945738..1946121) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /EC_number="4.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9169598, 12600205, 15033515, 26762040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9169598, 12600205, 15033515, 26762040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate 1-decarboxylase" /protein_id="NP_390122.1" /db_xref="EnsemblGenomes-Gn:BSU22410" /db_xref="EnsemblGenomes-Tr:CAB14157" /db_xref="GOA:P52999" /db_xref="InterPro:IPR003190" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG11493" /db_xref="UniProtKB/Swiss-Prot:P52999" /translation="MYRTMMSGKLHRATVTEANLNYVGSITIDEDLIDAVGMLPNEKV QIVNNNNGARLETYIIPGKRGSGVICLNGAAARLVQEGDKVIIISYKMMSDQEAASHE PKVAVLNDQNKIEQMLGNEPARTIL*" /label="panD CDS" gene complement(1945738..1946121) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /label="panD gene" CDS complement(1946123..1946983) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /EC_number="6.3.2.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17175524, 7037743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate synthetase" /protein_id="NP_390123.1" /db_xref="EnsemblGenomes-Gn:BSU22420" /db_xref="EnsemblGenomes-Tr:CAB14158" /db_xref="GOA:P52998" /db_xref="InterPro:IPR003721" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11520" /db_xref="UniProtKB/Swiss-Prot:P52998" /translation="MRQITDISQLKEAIKQYHSEGKSIGFVPTMGFLHEGHLTLADKA RQENDAVIMSIFVNPAQFGPNEDFEAYPRDIERDAALAENAGVDILFTPDAHDMYPGE KNVTIHVERRTDVLCGRSREGHFDGVAIVLTKLFNLVKPTRAYFGLKDAQQVAVVDGL ISDFFMDIELVPVDTVREEDGLAKSSRNVYLTAEERKEAPKLYRALQTSAELVQAGER DPEAVIKAAKDIIETTSGTIDYVELYSYPELEPVNEIAGKMILAVAVAFSKARLIDNI IIDIREMERI*" /label="panC CDS" gene complement(1946123..1946983) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /label="panC gene" CDS complement(1946985..1947818) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /EC_number="2.1.2.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 8096212; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ketopantoate hydroxymethyltransferase" /protein_id="NP_390124.1" /db_xref="EnsemblGenomes-Gn:BSU22430" /db_xref="EnsemblGenomes-Tr:CAB14159" /db_xref="GOA:P52996" /db_xref="InterPro:IPR003700" /db_xref="InterPro:IPR015813" /db_xref="SubtiList:BG11519" /db_xref="UniProtKB/Swiss-Prot:P52996" /translation="MKTKLDFLKMKESEEPIVMLTAYDYPAAKLAEQAGVDMILVGDS LGMVVLGLDSTVGVTVADMIHHTKAVKRGAPNTFIVTDMPFMSYHLSKEDTLKNAAAI VQESGADALKLEGGEGVFESIRALTLGGIPVVSHLGLTPQSVGVLGGYKVQGKDEQSA KKLIEDSIKCEEAGAMMLVLECVPAELTAKIAETLSIPVIGIGAGVKADGQVLVYHDI IGHGVERTPKFVKQYTRIDETIETAISGYVQDVRHRAFPEQKHSFQMNQTVLDGLYGG K*" /label="panB CDS" gene complement(1946985..1947818) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /label="panB gene" S_feature complement(1947819..1948026) /Source="Nicolas_S_feature" /locus_tag="new_2354673_2354880_c" /HighExp="LBGstat, dia15, Diami, H2O2, MG 15, Heat, Oxctl, MG 25, MG 10, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S852" promotor_-10 complement(1948021..1948040) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1948026) /Source="Nicolas_upshifts" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1948057..1948061) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1948064..1949041) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /EC_number="6.3.4.15" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12368242, 15459338, 28466579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 15459338, 28466579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor (BirA-biotinoyl-5'-AMP)" /protein_id="NP_390125.1" /db_xref="EnsemblGenomes-Gn:BSU22440" /db_xref="EnsemblGenomes-Tr:CAB14160" /db_xref="GOA:P0CI75" /db_xref="InterPro:IPR003142" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004408" /db_xref="InterPro:IPR004409" /db_xref="InterPro:IPR008988" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR030855" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11206" /db_xref="UniProtKB/Swiss-Prot:P0CI75" /translation="MRSTLRKDLIELFSQAGNEFISGQKISDALGCSRTAVWKHIEEL RKEGYEVEAVRRKGYRLIKKPGKLSESEIRFGLKTEVMGQHLIYHDVLSSTQKTAHEL ANNNAPEGTLVVADKQTAGRGRMSRVWHSQEGNGVWMSLILRPDIPLQKTPQLTLLAA VAVVQGIEEAAGIQTDIKWPNDILINGKKTVGILTEMQAEEDRVRSVIIGIGINVNQQ PNDFPDELKDIATSLSQAAGEKIDRAGVIQHILLCFEKRYRDYMTHGFTPIKLLWESY ALGIGTNMRARTLNGTFYGKALGIDDEGVLLLETNEGIKKIYSADIELG*" /label="birA CDS" gene complement(1948064..1949041) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /label="birA gene" CDS complement(1949026..1950219) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /EC_number="2.7.7.72" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9829937, 16109934, 20360175, 22940585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829937, 16109934, 20360175, 22940585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA nucleotidyltransferase" /protein_id="NP_390126.1" /db_xref="EnsemblGenomes-Gn:BSU22450" /db_xref="EnsemblGenomes-Tr:CAB14161" /db_xref="GOA:P42977" /db_xref="InterPro:IPR002646" /db_xref="InterPro:IPR023068" /db_xref="InterPro:IPR032810" /db_xref="InterPro:IPR032828" /db_xref="SubtiList:BG11208" /db_xref="UniProtKB/Swiss-Prot:P42977" /translation="MEKVFIKALPVLRILIEAGHQAYFVGGAVRDSYMKRTIGDVDIA TDAAPDQVERLFQRTVDVGKEHGTIIVLWEDETYEVTTFRTESDYVDFRRPSEVQFIS SLEEDLKRRDLTINAMAMTADGKVLDYFGGKKDIDQKVIRTVGKPEDRFQEDALRMLR AVRFMSQLGFTLSPETEEAIAKEKSLLSHVSVERKTIEFEKLLQGRASRQALQTLIQT RLYEELPGFYHKRENLISTSEFPFFSLTSREELWAALLINLGIVLKDAPLFLKAWKLP GKVIKEAIHIADTFGQSLDAMTMYRAGKKALLSAAKISQLRQNEKLDEKKLKDIQYAY QNLPIKSLKDLDITGKDLLALRNRPAGKWVSEELQWIEQAVVTGKLSNQKKHIEEWLK TCGQH*" /label="cca CDS" gene complement(1949026..1950219) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /label="cca gene" CDS complement(1950224..1951357) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /EC_number="2.4.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751541, 20308541, 22569254, 27454321, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751541, 20308541, 22569254, 27454321, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate synthase;malate glycosyltransferase for bacillithiol synthesis" /protein_id="NP_390127.1" /db_xref="EnsemblGenomes-Gn:BSU22460" /db_xref="EnsemblGenomes-Tr:CAB14162" /db_xref="GOA:P42982" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR023881" /db_xref="InterPro:IPR028098" /db_xref="PDB:5D00" /db_xref="PDB:5D01" /db_xref="SubtiList:BG11213" /db_xref="UniProtKB/Swiss-Prot:P42982" /translation="MRKLKIGITCYPSVGGSGIIATELGKQLAEKGHEIHFITSSIPF RLNTYHPNIHFHEVEVNQYAVFKYPPYDLTLASKIAEVAERENLDIIHAHYALPHAVC AYLAKQMLKRNIGIVTTLHGTDITVLGYDPSLKDLIRFAIESSDRVTAVSSALAAETY DLIKPEKKIETIYNFIDERVYLKKNTAAIKEKHGILPDEKVVIHVSNFRKVKRVQDVI RVFRNIAGKTKAKLLLVGDGPEKSTACELIRKYGLEDQVLMLGNQDRVEDLYSISDLK LLLSEKESFGLVLLEAMACGVPCIGTNIGGIPEVIKNNVSGFLVDVGDVTAATARAMS ILEDEQLSNRFTKAAIEMLENEFSSKKIVSQYEQIYADLAEPE*" /label="bshA CDS" gene complement(1950224..1951357) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /label="bshA gene" CDS complement(1951354..1952064) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /EC_number="3.5.1.-" /function="4.10: Glutathione and analogs" /experiment="publication(s) with functional evidences, PMID:11004195, 20308541, 23894131, 28117687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004195, 20308541, 23894131, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 1; malate N-acetylglucosamine N-acetyl hydrolase" /protein_id="NP_390128.2" /db_xref="EnsemblGenomes-Gn:BSU22470" /db_xref="EnsemblGenomes-Tr:CAB14163" /db_xref="GOA:P42981" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023842" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG11212" /db_xref="UniProtKB/Swiss-Prot:P42981" /translation="MYNADVLAFGAHSDDVEIGMGGTIAKFVKQEKKVMICDLTEAEL SSNGTVSLRKEEAAEAARILGADKRIQLTLPDRGLIMSDQAIRSIVTVIRICRPKAVF MPYKKDRHPDHGNAAALVEEAIFSAGIHKYKDEKSLPAHKVSKVYYYMINGFHQPDFV IDISDTIEAKKQSLNAYKSQFIPSKDSVSTPLTNGYIEIVEAREKLYGKEAGVEYAEG FFSKRMLMLDHDVLGGEQ*" /label="bshBA CDS" gene complement(1951354..1952064) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /label="bshBA gene" CDS complement(1952057..1952470) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /EC_number="4.2.3.3" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxal synthase" /protein_id="NP_390129.1" /db_xref="EnsemblGenomes-Gn:BSU22480" /db_xref="EnsemblGenomes-Tr:CAB14164" /db_xref="GOA:P42980" /db_xref="InterPro:IPR004363" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR018148" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG11211" /db_xref="UniProtKB/Swiss-Prot:P42980" /translation="MKIALIAHDKKKQDMVQFTTAYRDILKNHDLYATGTTGLKIHEA TGLQIERFQSGPLGGDQQIGALIAANALDLVIFLRDPLTAQPHEPDVSALIRLCDVYS IPLATNMGTAEILVRTLDEGVFEFRDLLRGEEPNV*" /label="mgsA CDS" gene complement(1952057..1952470) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /label="mgsA gene" CDS complement(1952486..1953289) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /EC_number="1.17.1.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6422596, 9398235, 12682299, 20503968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(4S)-4-hydroxy-2,3,4, 5-tetrahydro-(2S)-dipicolinic acid (HTPA) dehydratase reductase" /protein_id="NP_390130.1" /db_xref="EnsemblGenomes-Gn:BSU22490" /db_xref="EnsemblGenomes-Tr:CAB14165" /db_xref="GOA:P42976" /db_xref="InterPro:IPR000846" /db_xref="InterPro:IPR022663" /db_xref="InterPro:IPR022664" /db_xref="InterPro:IPR023940" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11207" /db_xref="UniProtKB/Swiss-Prot:P42976" /translation="MSNETIKLVIAGPRGRMGQEAVKLAERTPHFDLVGAIDHTYDQQ KLSDVMPVESDAFIYTDIHACFTETQPDVLIDLTTPEIGKVHTKIALEHGVRPVVGTT GFSEADLKELTSLTEEKGIGAIIAPNFALGAILMMKFSKMAANYFEDVEIIELHHDQK LDAPSGTALKTAEMISEVRKEKQQGHPDEKEILPGARGAEQNGIRLHSVRLPGLIAHQ EVMFGMDGQTLQIRHDSYNRASFMSGVKLSVEQVMKIDQLVYGLENIID*" /label="dapB CDS" gene complement(1952486..1953289) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /label="dapB gene" CDS complement(1953301..1953636) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16390452, 20529853, 20944217, 21733847, 24339782, 26920050, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidized nucleotide pyrophosphohydrolase" /protein_id="NP_390131.1" /db_xref="EnsemblGenomes-Gn:BSU22500" /db_xref="EnsemblGenomes-Tr:CAB14166" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR012359" /db_xref="PDB:2GTA" /db_xref="SubtiList:BG11210" /db_xref="UniProtKB/Swiss-Prot:P42979" /translation="MSDKTMKDIQAEVDRYIGQFKEGYFSPLAMMARLTEELGELARE VNHRYGEKPKKATEDDKSMEEEIGDVLFVLVCLANSLDISLEEAHDRVMHKFNTRDKD RWTRKEEGK*" /label="ypjD CDS" gene complement(1953301..1953636) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /label="ypjD gene" promotor_-10 complement(1953656..1953675) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(1953666) /Source="Nicolas_upshifts" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(1953689..1953696) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" promotor_-35 1953705..1953712 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1953721..1953740) /Source="Nicolas_upshift_promotors" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1953726..1953745 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1953732 /Source="Nicolas_upshifts" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1953740) /Source="Nicolas_upshifts" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" CDS 1953776..1954648 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390132.2" /db_xref="EnsemblGenomes-Gn:BSU22510" /db_xref="EnsemblGenomes-Tr:CAB14167" /db_xref="GOA:P42978" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11209" /db_xref="UniProtKB/Swiss-Prot:P42978" /translation="MLGEIRLKNIFFILIGAAIFSFGLVHFNMQNNLAEGGFTGITLL LYALFHISPSISNLVLNIPIFFIGWRLLGRTMFVYTLVGTVALSLFLSIFQRYEIHMP LQHDLALAALFAGVFIGAGLGIIFKFGGTTGGVDIIARLVNKYFGIPMGRTMFAFDAC VIILSLLTYLSYKEAMYTLVAVFVAARLIDFIQEGGYAAKGATIISSKNDLIQKKILE EMERGVTILKGQGSYTKEDIDVLYCVVPKNELVMLKSVINSIDPHAFVAVSDVHDVLG EGFTLDENKNPLPR*" /label="ypjC CDS" gene 1953776..1954648 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /label="ypjC gene" CDS complement(1954690..1955484) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="sporulation septum-associated protein" /protein_id="NP_390133.1" /db_xref="EnsemblGenomes-Gn:BSU22520" /db_xref="EnsemblGenomes-Tr:CAB14168" /db_xref="GOA:P54393" /db_xref="InterPro:IPR014231" /db_xref="SubtiList:BG11500" /db_xref="UniProtKB/Swiss-Prot:P54393" /translation="MKRKLTICLLIALIFYNGNAKAAERGSLEELNDLSDTVFQMTRQ AKYEEALQVLEYFEKTLKSAEKKQQDPMLTGAQIRQITLGYNDMVRSLKQADTSDTQK LRAAAQFRMLMDAVDNRSDPLWGSLEKPIMEAFTELKRDVQKNGSTSFHEKWNEFISL YDLIYPSLTIDVSEDQLETVGKHIDVIEQEEFQQMTESTKLERLSLLQHDLKNVFDRV EEDDADPSLLWVIITTGSIIITALTYVGYRKYKAEKNKLKKRDYPK*" /label="ypjB CDS" gene complement(1954690..1955484) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /label="ypjB gene" downshifts complement(1954715) /Source="Nicolas_upshifts" /id="D1176" /incds=0 /nref=4 /ntot=106 /MaxReadThrough="1.96946" /MaxDrop="3.51024" /score="34.9661402" /energy="-11.3" /TU="NA" /idTUdmin="U1765" /TUdmin=198 /isTUend="FALSE" /label="downshifts" S_feature complement(1955485..1955552) /Source="Nicolas_S_feature" /locus_tag="new_2362339_2362406_c" /HighExp="LBGstat, C30, S0, LoTm, G180, G135, G150, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S853" CDS complement(1955553..1956110) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390134.1" /db_xref="EnsemblGenomes-Gn:BSU22530" /db_xref="EnsemblGenomes-Tr:CAB14169" /db_xref="GOA:P54392" /db_xref="InterPro:IPR009845" /db_xref="SubtiList:BG11499" /db_xref="UniProtKB/Swiss-Prot:P54392" /translation="MLILVLAINFLGTVYGYYWYLPQLLETPARFLIFVPDSPTATFF FLFVLLAFLMKRNAPLLEALALVTLVKYGLWAVAMNFLVLAVTGDLPWEGYMLIASHF AMAVQGVLYSPYFRFSFWHLAIAAVWTLHNDVIDYLFDMMPQYSMLSDYMTEIGYGTF WLSIFSIALAYFLVVSKKQTKLELM*" /label="ypjA CDS" gene complement(1955553..1956110) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /label="ypjA gene" S_feature complement(1956111..1956190) /Source="Nicolas_S_feature" /locus_tag="new_2362965_2363044_c" /HighExp="C30, UNK1, G135, BMM, G150, G180, Oxctl, LoTm, Paraq, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S854" downshifts complement(1956235) /Source="Nicolas_upshifts" /id="D1177" /incds=0 /nref=131 /ntot=215 /MaxReadThrough="3.97061" /MaxDrop="6.41485" /score="13.3880841" /energy="-8" /TU="U1765" /idTUdmin="U1767" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1956257..1957024) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome cc subunit)" /protein_id="NP_390135.1" /db_xref="EnsemblGenomes-Gn:BSU22540" /db_xref="EnsemblGenomes-Tr:CAB14170" /db_xref="GOA:P46913" /db_xref="InterPro:IPR005798" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012049" /db_xref="InterPro:IPR027387" /db_xref="InterPro:IPR036150" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG11327" /db_xref="UniProtKB/Swiss-Prot:P46913" /translation="MHRGKGMKFVGDSRIPAEKKPNIPKDYSEYPGKTEAFWPNFLLK EWMVGAVFLIGFLVLTIVHQPPLERMADPTDTGYIPLPDWYFLFLYQLLKYEYAAGSF TVVGAMIMPGLAFGALLLAPFLDRGTERRPWKRPVAVGMMLLAISAAVFLTWQSVATH DWAKAEEQGKITKEADIDTNAEGYKVFKEQGCISCHGDNLQGGAAGPSLVDSGLKPDE IKKIAVEGKGKMPAGVFKGNDKQLEELAKFISETTAK*" /label="qcrC CDS" gene complement(1956257..1957024) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /label="qcrC gene" CDS complement(1957059..1957733) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 15849754, 16850406; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome b subunit)" /protein_id="NP_390136.1" /db_xref="EnsemblGenomes-Gn:BSU22550" /db_xref="EnsemblGenomes-Tr:CAB14171" /db_xref="GOA:P46912" /db_xref="InterPro:IPR005797" /db_xref="InterPro:IPR016174" /db_xref="InterPro:IPR023530" /db_xref="InterPro:IPR027387" /db_xref="SubtiList:BG11326" /db_xref="UniProtKB/Swiss-Prot:P46912" /translation="MLNKIYDWVDERLDITPMWRDIADHEVPEHVNPAHHFSAFVYCF GGLTFFVTVIQVLSGMFLTMYYVPDIKNAWESVYYLQNEVAFGQIVRGMHHWGASLVI VMMFLHTLRVFFQGAYKKPRELNWIVGVLIFFVMLGLGFTGYLLPWDMKALFATKVGL QIAEATPLIGTQVKTLLAGHPDIVGAQTLTRFFAIHVFFLPAALFGLMAAHFIMIRKQ GISGPL*" /label="qcrB CDS" gene complement(1957059..1957733) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /label="qcrB gene" CDS complement(1957735..1958238) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /EC_number="1.10.2.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 24652282, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (iron-sulfur subunit)" /protein_id="NP_390137.1" /db_xref="EnsemblGenomes-Gn:BSU22560" /db_xref="EnsemblGenomes-Tr:CAB14172" /db_xref="GOA:P46911" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR014349" /db_xref="InterPro:IPR014909" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11325" /db_xref="UniProtKB/Swiss-Prot:P46911" /translation="MGGKHDISRRQFLNYTLTGVGGFMAASMLMPMVRFALDPVLKST GKQDMVQVVSVDELTKEPQRFDFKINQVDAWYESEESRSAWVFKNGDEIVALSPICKH LGCTVNWNSDPKNPNKFFCPCHYGLYEKDGTNVPGTPPLAPLDHYEQEVKDGFLYLGK AKPKGEG*" /label="qcrA CDS" gene complement(1957735..1958238) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /label="qcrA gene" downshifts 1958247 /Source="Nicolas_upshifts" /id="D1178" /incds=0 /nref=1 /ntot=80 /MaxReadThrough="1.24169" /MaxDrop="3.42621" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=3608 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1958302..1958321) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1958302) /Source="Nicolas_upshifts" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1958336..1958343) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1958381..1958827) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15743949" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390138.1" /db_xref="EnsemblGenomes-Gn:BSU22570" /db_xref="EnsemblGenomes-Tr:CAB14173" /db_xref="InterPro:IPR019615" /db_xref="SubtiList:BG11498" /db_xref="UniProtKB/Swiss-Prot:P54391" /translation="MRWRITDAKDYLQAKDYIDTAVIPLINIRVNNHFKMAAEKGEFT QLLSEELERQLKGRVYLLPPYTYVDRNEITVQGLKDLREELITEFPHVVLLTSDESWR AEDALGKMIVTSSVPLEHLNDSLKRKILDERTAEILNVLLQLWSTL*" /label="ypiF CDS" gene complement(1958381..1958827) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /label="ypiF gene" downshifts 1958830 /Source="Nicolas_upshifts" /id="D1179" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="0.94679" /MaxDrop="2.794" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=4191 /isTUend="FALSE" /label="downshifts" CDS complement(1958882..1959421) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16847875" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390139.1" /db_xref="EnsemblGenomes-Gn:BSU22580" /db_xref="EnsemblGenomes-Tr:CAB14174" /db_xref="InterPro:IPR011188" /db_xref="InterPro:IPR014957" /db_xref="InterPro:IPR014963" /db_xref="SubtiList:BG11497" /db_xref="UniProtKB/Swiss-Prot:P54390" /translation="MQTPVSVNEKKDFIRWFLNHYQLKRRECVWILNYLMSHDSLMEK VHFVEQAEFCPRGIIMSTHCVEEVPFRFYKENVMTTDAEKSFHDIRLNKQQDLFIQLN FRSAYSSPEYAAVLESNPHIPKNLFENKKDQGLAEQILEHAISTFQREKLLKDIDDAL DRHDKEAFEQLSRQLNQLT*" /label="ypiB CDS" gene complement(1958882..1959421) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /label="ypiB gene" downshifts complement(1958895) /Source="Nicolas_upshifts" /id="D1180" /incds=0 /nref=84 /ntot=250 /MaxReadThrough="5.68366" /MaxDrop="5.48142" /score="16.8021869" /energy="-11.2" /TU="U1766,U1767" /idTUdmin="U1768" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1959454..1959472) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(1959465) /Source="Nicolas_upshifts" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="upshifts" promotor_-35 complement(1959484..1959492) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" CDS complement(1959493..1960764) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390140.1" /db_xref="EnsemblGenomes-Gn:BSU22590" /db_xref="EnsemblGenomes-Tr:CAB14175" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11496" /db_xref="UniProtKB/Swiss-Prot:P54389" /translation="MNTLIQEAIKLVEAGETEKGLNTLSKAEKQLHDEDKAIAAQLYY EWGDVEKAISLISDLHDLYPNETELTNFYAELLIDIDEEEKALAVLETIPETDPSYPE SLLLMADLYQMQGLFEVSEQKLFQAKSILDNEPVIDFALGELYFAQGAYAKAVQYFKT TAEEQSEIGGVNVHQRLAESLSASGEFEDAIPWYEKAVDENPDPNTIFGYGFTALQAG LVKTAIKQLSDLKELDPSYTSLYMPLSKSYEAEGMYEEALKTAKEGIRYDEYNKELFL YAAKMALKIGKSEEGKKLLQEALALDPGFVEALHTLLAVYHKEEDYDQIIDLIQEVRS YGEEDPKYNWYLASAYTELEQYEEAKQSFEAAYLHYREDRDFLYEYASFLLEEGLQKE ALPLLKKVLEMDGANEELEETILRIEDEFSR*" /label="ypiA CDS" gene complement(1959493..1960764) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /label="ypiA gene" S_feature complement(1960765..1960832) /Source="Nicolas_S_feature" /locus_tag="new_2367619_2367686_c" /HighExp="dia15, Diami, dia5, Etha, H2O2, T1.30H, LPhT, T0.30H, T3.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF, SigA" /TUshortPSig="0.999, 0.999, 0.999, 1" /TUlongSig="Sig-, Sig-, SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.047, 0.994, 0.999, 1, 0.999, 1, 0.998" /label="S855" promotor_-10 complement(1960829..1960848) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1960832) /Source="Nicolas_upshifts" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1960862..1960869) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1960899..1960918) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(1960905) /Source="Nicolas_upshifts" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="upshifts" S_feature complement(1960907..1961051) /Source="Nicolas_S_feature" /locus_tag="new_2367761_2367905_c" /HighExp="S3, LoTm, M9-stat, S4, Etha, S5, T5.0H, BT, B36, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.047, 0.994" /TUlongSig="Sig-, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.999, 1, 0.999, 1, 0.998" /label="S856" promotor_-35 complement(1960929..1960936) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" promotor_-10 complement(1961033..1961051) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(1961051) /Source="Nicolas_upshifts" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(1961067..1961072) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(1961100..1962386) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /EC_number="2.5.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3106153, 22938038, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvoylshikimate-3-phosphate synthase)" /protein_id="NP_390141.1" /db_xref="EnsemblGenomes-Gn:BSU22600" /db_xref="EnsemblGenomes-Tr:CAB14176" /db_xref="GOA:P20691" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR006264" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR023193" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10294" /db_xref="UniProtKB/Swiss-Prot:P20691" /translation="MKRDKVQTLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPG ADCLSTIDCFRKMGVHIEQSSSDVVIHGKGIDALKEPESLLDVGNSGTTIRLMLGILA GRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASLKGIDYVS PVASAQIKSAVLLAGLQAEGTTTVTEPHKSRDHTERMLSAFGVKLSEDQTSVSIAGGQ KLTAADIFVPGDISSAAFFLAAGAMVPNSRIVLKNVGLNPTRTGIIDVLQNMGAKLEI KPSADSGAEPYGDLIIETSSLKAVEIGGDIIPRLIDEIPIIALLATQAEGTTVIKDAA ELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKGGAAVSSHGDHRIGMMLG IASCITEEPIEIEHTDAIHVSYPTFFEHLNKLSKKS*" /label="aroA CDS" gene complement(1961100..1962386) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /label="aroA gene" downshifts complement(1961123) /Source="Nicolas_upshifts" /id="D1181" /incds=0 /nref=68 /ntot=212 /MaxReadThrough="3.64462" /MaxDrop="4.25336" /score="16.8021869" /energy="-11.2" /TU="U1770,U1772,U1773" /idTUdmin="U1775" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1962397..1963512) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /EC_number="1.3.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106153, 3121591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106153, 3121591; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydrogenase" /protein_id="NP_390142.1" /db_xref="EnsemblGenomes-Gn:BSU22610" /db_xref="EnsemblGenomes-Tr:CAB14177" /db_xref="GOA:P20692" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003099" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10293" /db_xref="UniProtKB/Swiss-Prot:P20692" /translation="MNQMKDTILLAGLGLIGGSIALAIKKNHPGKRIIGIDISDEQAV AALKLGVIDDRADSFISGVKEAATVIIATPVEQTLVMLEELAHSGIEHELLITDVGST KQKVVDYADQVLPSRYQFVGGHPMAGSHKSGVAAAKEFLFENAFYILTPGQKTDKQAV EQLKNLLKGTNAHFVEMSPEEHDGVTSVISHFPHIVAASLVHQTHHSENLYPLVKRFA AGGFRDITRIASSSPAMWRDILLHNKDKILDRFDEWIREIDKIRTYVEQEDAENLFRY FKTAKDYRDGLPLRQKGAIPAFYDLYVDVPDHPGVISEITAILAAERISITNIRIIET REDINGILRISFQSDDDRKRAEQCIEARAEYETFYAD*" /label="tyrA CDS" gene complement(1962397..1963512) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /label="tyrA gene" CDS complement(1963561..1964643) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /EC_number="2.6.1.5" /EC_number="2.6.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4431, 418816, 824269, 11518529, 15102328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4431, 418816, 824269, 11518529, 15102328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol-phosphate aminotransferase; tyrosine/phenylalanine aminotransferase (promiscuous)" /protein_id="NP_390143.2" /db_xref="EnsemblGenomes-Gn:BSU22620" /db_xref="EnsemblGenomes-Tr:CAB14178" /db_xref="GOA:P17731" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR005861" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10292" /db_xref="UniProtKB/Swiss-Prot:P17731" /translation="MRIKEHLKQLKPYQPGKPIEAVKSEYGLDKVVKLASNENPYGCS EAAKEALHHEIQQLALYPDGYSAALRTRLSKHLNVSETSLIFGNGSDEIIQIICRAFL NDKTNTVTAAPTFPQYKHNAVIEGAEVREIALRPDGSHDLDAMLEAIDEQTQVVWICS PNNPTGTYTSEGELLAFLERVPSRVLVVLDEAYYEYVTAEDYPETVPLLSKYSNLMIL RTFSKAYGLAALRVGYGIADENLIRQIEPAREPFNTSRLGQAAAIAALDDQAFIASCV EQNNAGLQQYYDFAKTHGLKCYPSQTNFVLIDFKRPADELFQALLEKGYIVRSGNALG FPTSLRITIGTKEQNEEILAILAEIL*" /label="hisC CDS" gene complement(1963561..1964643) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /label="hisC gene" CDS complement(1964654..1965457) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (alpha subunit)" /protein_id="NP_390144.1" /db_xref="EnsemblGenomes-Gn:BSU22630" /db_xref="EnsemblGenomes-Tr:CAB14179" /db_xref="GOA:P07601" /db_xref="InterPro:IPR002028" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018204" /db_xref="SubtiList:BG10291" /db_xref="UniProtKB/Swiss-Prot:P07601" /translation="MFKLDLQPSEKLFIPFITAGDPVPEVSIELAKSLQKAGATALEL GVAYSDPLADGPVIQRASKRALDQGMNIVKAIELGGEMKKNGVNIPIILFTYYNPVLQ LNKEYFFALLRENHIDGLLVPDLPLEESNSLQEECKSHEVTYISLVAPTSESRLKTII EQAEGFVYCVSSLGVTGVRNEFNSSVYPFIRTVKNLSTVPVAVGFGISNREQVIKMNE ISDGVVVGSALVRKIEELKDRLISAETRNQALQEFEDYAMAFSGLYSLK*" /label="trpA CDS" gene complement(1964654..1965457) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /label="trpA gene" promotor_-10 complement(1965142..1965161) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(1965159) /Source="Nicolas_upshifts" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(1965173..1965180) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(1965450..1966652) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (beta subunit)" /protein_id="NP_390145.2" /db_xref="EnsemblGenomes-Gn:BSU22640" /db_xref="EnsemblGenomes-Tr:CAB14180" /db_xref="GOA:P07600" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR006653" /db_xref="InterPro:IPR006654" /db_xref="InterPro:IPR023026" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10290" /db_xref="UniProtKB/Swiss-Prot:P07600" /translation="MYPYPNEIGRYGDFGGKFVPETLMQPLDEIQTAFKQIKDDPAFR EEYYKLLKDYSGRPTALTYADRVTEYLGGAKIYLKREDLNHTGSHKINNALGQALLAK KMGKTKIIAETGAGQHGVAAATVAAKFGFSCTVFMGEEDVARQSLNVFRMKLLGAEVV PVTSGNGTLKDATNEAIRYWVQHCEDHFYMIGSVVGPHPYPQVVREFQKMIGEEAKDQ LKRIEGTMPDKVVACVGGGSNAMGMFQAFLNEDVELIGAEAAGKGIDTPLHAATISKG TVGVIHGSLTYLIQDEFGQIIEPYSISAGLDYPGIGPEHAYLHKSGRVTYDSITDEEA VDALKLLSEKEGILPAIESAHALAKAFKLAKGMDRGQLILVCLSGRGDKDVNTLMNVL EEEVKAHV*" /label="trpB CDS" gene complement(1965450..1966652) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /label="trpB gene" CDS complement(1966633..1967280) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /EC_number="5.3.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylanthranilate isomerase" /protein_id="NP_390146.3" /db_xref="EnsemblGenomes-Gn:BSU22650" /db_xref="EnsemblGenomes-Tr:CAB14181" /db_xref="GOA:P20167" /db_xref="InterPro:IPR001240" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10289" /db_xref="UniProtKB/Swiss-Prot:P20167" /translation="MKKPALKYCGIRSLKDLQLAAESQADYLGFIFAESKRKVSPEDV KKWLNQVRVEKQVAGVFVNESIETMSRIAKSLKLDVIQLHGDEKPADAAALRKLTGCE IWKALHHQDNTTQEIARFKDNVDGFVIDSSVKGSRGGTGVAFSWECVPEYQQAAIGKR CFIAGGVNPDSITRLLKWQPEGIDLASGIEKNGQKDQNLMRLLEERMNRYVSISE*" /label="trpF CDS" gene complement(1966633..1967280) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /label="trpF gene" downshifts complement(1966727) /Source="Nicolas_upshifts" /id="D1182" /incds=1 /nref=30 /ntot=83 /MaxReadThrough="8.17917" /MaxDrop="5.75867" /score="2.96963632" /energy="-11.9" /TU="U1771,U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=616 /isTUend="FALSE" /label="downshifts" misc_feature complement(1966903..1966906) /Source="Nicolas_upshift_promotors" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1966903) /Source="Nicolas_upshifts" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" downshifts complement(1967123) /Source="Nicolas_upshifts" /id="D1183" /incds=1 /nref=1 /ntot=84 /MaxReadThrough="8.55417" /MaxDrop="3.4408" /score="2.96963632" /energy="-11.9" /TU="U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=220 /isTUend="FALSE" /label="downshifts" misc_feature 1967285..1968037 /created_by="AR/SM" /id="IIG_Bs01" /note="due to the curing of the trpC2 locus (auxotrophy) of the Delta6 strain by transformation with chromosomal DNA from donor Bsu 3NA multiple snp`s were transferred to the oroginal trpC locus" /modified_by="User" /label="IIG_Bs01" /note="Geneious type: MiniBacillus__exchange" CDS complement(1967285..1968037) /locus_tag="PG10_trpC_var_BEP06_07765" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_007409461.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="indole-3-glycerol phosphate synthase" /protein_id="ANY35339.1" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /translation="MLEKIIKQKKEEVKTLVLPVEQPFEKRSFKEALASLNRFIGLIA EVKKASPSKGLIKENFVPVRIAKDYETAKADALSVLTDTPFFQGENSYLSDVKRAVSI PVLRKDFIIDSLQVEESRRIGADAILLIGEVLDPLHLHELYLEAGEKEMDVLVEVHDA TTLEQILKVFTPDILGINNRNLKTFETSIMQTEQIASLAPKESLLVSESGIGSLEHLT FVKEHGARAVLIGESLMRQTSQRKAIHALFRE*" /label="PG10_trpC_var_BEP06_07765" gene complement(1967285..1968037) /locus_tag="PG10_trpC_var_BEP06_07765" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /label="PG10_trpC_var_BEP06_07765" misc_feature complement(1967318..1967320) /Source="Nicolas_upshift_promotors" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1967321 /Source="Nicolas_upshifts" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" Polymorphism join(1967427,1967430) /Source="geneious" /ID="SNP_BsPG10_2374282_2374283" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change /CDS_Position=606 /Change="AG -> GT" /Codon_Change="TCC,TTG -> TCA,CTG" /Coverage="129 -> 130" /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="AG" /Variant_Nucleotides="GT" /Variant_P_Value="2e-203" /Variant_Raw_Frequency="128 -> 129" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967441,1967443) /Source="geneious" /ID="SNP_BsPG10_2374296_2374296" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> A" /CDS_Position=593 /Change="A -> G" /Codon_Change="GTT -> GCT" /Coverage=119 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.2e-179" /Variant_Raw_Frequency=119 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967443,1967445) /Source="geneious" /ID="SNP_BsPG10_2374298_2374298" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=591 /Change="G -> A" /Codon_Change="CTC -> CTT" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="9.9e-148" /Variant_Raw_Frequency=116 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967468,1967470) /Source="geneious" /ID="SNP_BsPG10_2374323_2374323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="K -> M" /CDS_Position=566 /Change="T -> A" /Codon_Change="AAG -> ATG" /Coverage=81 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="A" /Variant_P_Value="6.3e-98" /Variant_Raw_Frequency=81 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967470,1967474) /Source="geneious" /ID="SNP_BsPG10_2374325_2374327" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="V -> I" /CDS_Position=562 /Change="TAC -> GAT" /Codon_Change="GTA -> ATC" /Coverage="79 -> 84" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="TAC" /Variant_Nucleotides="GAT" /Variant_P_Value="2.3e-77" /Variant_Raw_Frequency="74 -> 78" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967476,1967478) /Source="geneious" /ID="SNP_BsPG10_2374331_2374331" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=558 /Change="T -> G" /Codon_Change="ACA -> ACC" /Coverage=70 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="1e-63" /Variant_Raw_Frequency=70 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967485,1967487) /Source="geneious" /ID="SNP_BsPG10_2374340_2374340" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=549 /Change="C -> A" /Codon_Change="ACG -> ACT" /Coverage=59 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="A" /Variant_P_Value="1e-59" /Variant_Raw_Frequency=59 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967500,1967502) /Source="geneious" /ID="SNP_BsPG10_2374355_2374355" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=534 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=66 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="6e-64" /Variant_Raw_Frequency=65 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967503,1967505) /Source="geneious" /ID="SNP_BsPG10_2374358_2374358" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=531 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=63 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.3e-68" /Variant_Raw_Frequency=60 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967508,1967510) /Source="geneious" /ID="SNP_BsPG10_2374363_2374363" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> I" /CDS_Position=526 /Change="C -> T" /Codon_Change="GTA -> ATA" /Coverage=65 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="3.9e-82" /Variant_Raw_Frequency=64 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967518,1967520) /Source="geneious" /ID="SNP_BsPG10_2374373_2374373" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=516 /Change="G -> A" /Codon_Change="GAC -> GAT" /Coverage=79 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="7.7e-116" /Variant_Raw_Frequency=78 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967521,1967523) /Source="geneious" /ID="SNP_BsPG10_2374376_2374376" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=513 /Change="G -> A" /Codon_Change="CCC -> CCT" /Coverage=92 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="4e-141" /Variant_Raw_Frequency=90 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967524,1967526) /Source="geneious" /ID="SNP_BsPG10_2374379_2374379" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=510 /Change="T -> C" /Codon_Change="ACA -> ACG" /Coverage=97 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.3e-165" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967530,1967532) /Source="geneious" /ID="SNP_BsPG10_2374385_2374385" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=504 /Change="C -> T" /Codon_Change="GTG -> GTA" /Coverage=109 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="4.3e-193" /Variant_Raw_Frequency=108 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967556,1967558) /Source="geneious" /ID="SNP_BsPG10_2374411_2374411" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="S -> T" /CDS_Position=478 /Change="A -> T" /Codon_Change="TCA -> ACA" /Coverage=148 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value="2.9e-307" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967588,1967590) /Source="geneious" /ID="SNP_BsPG10_2374443_2374443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="G -> E" /CDS_Position=446 /Change="C -> T" /Codon_Change="GGG -> GAG" /Coverage=161 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=161 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967641,1967643) /Source="geneious" /ID="SNP_BsPG10_2374496_2374496" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=393 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=174 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967689,1967691) /Source="geneious" /ID="SNP_BsPG10_2374544_2374544" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=345 /Change="T -> C" /Codon_Change="GTA -> GTG" /Coverage=168 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=167 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967704,1967708) /Source="geneious" /ID="SNP_BsPG10_2374559_2374558" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=0 /Amino_Acid_Change="-> I" /CDS_Position=331 /Change="AAT" /Codon_Change="-> ATT" /Coverage=164 /locus_tag="BSU_22660" /Protein_Effect="Insertion" /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="AAT" /Variant_P_Value="3.90000001038273e-316" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967722,1967724) /Source="geneious" /ID="SNP_BsPG10_2374574_2374574" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=315 /Change="A -> G" /Codon_Change="CTT -> CTC" /Coverage=155 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967731,1967733) /Source="geneious" /ID="SNP_BsPG10_2374583_2374583" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=306 /Change="A -> T" /Codon_Change="ATT -> ATA" /Coverage=153 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=152 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967743,1967745) /Source="geneious" /ID="SNP_BsPG10_2374595_2374595" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=294 /Change="A -> G" /Codon_Change="CGT -> CGC" /Coverage=128 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="4e-295" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967808,1967810) /Source="geneious" /ID="SNP_BsPG10_2374660_2374660" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="I -> L" /CDS_Position=229 /Change="T -> G" /Codon_Change="ATT -> CTT" /Coverage=131 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="2.3e-302" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967818,1967820) /Source="geneious" /ID="SNP_BsPG10_2374670_2374670" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=219 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=126 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="1.6e-290" /Variant_Raw_Frequency=126 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967826,1967829) /Source="geneious" /ID="SNP_BsPG10_2374678_2374679" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="EA -> ET" /CDS_Position=210 /Change="CC -> TT" /Codon_Change="GAG,GCT -> GAA,ACT" /Coverage="124 -> 130" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="CC" /Variant_Nucleotides="TT" /Variant_P_Value="4.7e-253" /Variant_Raw_Frequency="119 -> 125" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967846,1967848) /Source="geneious" /ID="SNP_BsPG10_2374698_2374698" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="Q -> R" /CDS_Position=191 /Change="T -> C" /Codon_Change="CAG -> CGG" /Coverage=104 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="9e-228" /Variant_Raw_Frequency=101 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967862,1967864) /Source="geneious" /ID="SNP_BsPG10_2374714_2374714" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="D -> N" /CDS_Position=175 /Change="C -> T" /Codon_Change="GAT -> AAT" /Coverage=95 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency="1.1%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="2.8e-220" /Variant_Raw_Frequency=93 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967890,1967892) /Source="geneious" /ID="SNP_BsPG10_2374742_2374742" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=147 /Change="T -> C" /Codon_Change="GCA -> GCG" /Coverage=98 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.2e-260" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967905,1967907) /Source="geneious" /ID="SNP_BsPG10_2374757_2374757" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=132 /Change="G -> A" /Codon_Change="GCC -> GCT" /Coverage=197 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value /Variant_Raw_Frequency /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967930,1967932) /Source="geneious" /ID="SNP_BsPG10_2374782_2374782" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="P -> L" /CDS_Position=107 /Change="G -> A" /Codon_Change="CCG -> CTG" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value=0 /Variant_Raw_Frequency=118 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967947,1967949) /Source="geneious" /ID="SNP_BsPG10_2374799_2374799" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=90 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=133 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=131 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1967962,1967964) /Source="geneious" /ID="SNP_BsPG10_2374814_2374814" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=75 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=130 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=130 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" CDS complement(1968030..1969046) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /EC_number="2.4.2.18" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 17114058; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="anthranilate phosphoribosyltransferase" /protein_id="NP_390148.2" /db_xref="EnsemblGenomes-Gn:BSU22670" /db_xref="EnsemblGenomes-Tr:CAB14183" /db_xref="GOA:P03947" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR005940" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="SubtiList:BG10288" /db_xref="UniProtKB/Swiss-Prot:P03947" /modified_by="User" /translation="MNRFLQLCVDGKTLTAGEAETLMNMMMAAEMTPSEMGGILSILA HRGETPEELAGFVKAMRAHALTVDGLPDIVDTCGTGGDGISTFNISTASAIVASAAGA KIAKHGNRSVSSKSGSADVLEELEVSIQTTPEKVKSSIETNNMGFLFAPLYHSSMKHV AGTRKELGFRTVFNLLGPLSNPLQAKRQVIGVYSVEKAGLMASALETFQPKHVMFVSS RDGLDELSITAPTDVIELKDGERREYTVSPEDFGFTNGRLEDLQVQSPKESAYLIQNI FENKSSSSALSITAFNAGAAIYTAGITASLKEGTELALETITSGGAAAQLERLKQKEE EIYA*" /label="trpD CDS" gene complement(1968030..1969046) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /modified_by="User" /label="trpD gene" CDS complement(1969018..1970565) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anthranilate synthase" /protein_id="NP_390149.1" /db_xref="EnsemblGenomes-Gn:BSU22680" /db_xref="EnsemblGenomes-Tr:CAB14184" /db_xref="GOA:P03963" /db_xref="InterPro:IPR005256" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10287" /db_xref="UniProtKB/Swiss-Prot:P03963" /translation="MNFQSNISAFLEDSLSHHTIPIVETFTVDTLTPIQMIEKLDREI TYLLESKDDTSTWSRYSFIGLNPFLTIKEEQGRFSAADQDSKSLYTGNELKEVLNWMN TTYKIKTPELGIPFVGGAVGYLSYDMIPLIEPSVPSHTKETDMEKCMLFVCRTLIAYD HETKNVHFIQYARLTGEETKNEKMDVFHQNHLELQNLIEKMMDQKNIKELFLSADSYK TPSFETVSSNYEKSAFMADVEKIKSYIKAGDIFQGVLSQKFEVPIKADAFELYRVLRI VNPSPYMYYMKLLDREIVGSSPERLIHVQDGHLEIHPIAGTRKRGADKAEDERLKVEL MKDEKEKAEHYMLVDLARNDIGRVAEYGSVSVPEFTKIVSFSHVMHIISVVTGRLKKG VHPVDALMSAFPAGTLTGAPKIRAMQLLQELEPTPRETYGGCIAYIGFDGNIDSCITI RTMSVKNGVASIQAGAGIVADSVPEAEYEESCNKAGALLKTIHIAEDMFHSKEDKADE QISTIVR*" /label="trpE CDS" gene complement(1969018..1970565) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /label="trpE gene" S_feature complement(1970644..1970775) /Source="Nicolas_S_feature" /locus_tag="new_2377495_2377626_c" /HighExp="Etha, S1, GM 25, GM 15, HiTm, Glu, MG-0.1, GM 60, M9-exp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.994, 0.647, 0.999, 1, 0.996" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.998" /label="S857" downshifts complement(1970687) /Source="Nicolas_upshifts" /id="D1184" /incds=0 /nref=61 /ntot=157 /MaxReadThrough="7.41666" /MaxDrop="5.25158" /score="2.96963632" /energy="-11.9" /TU="U1773,U1774,U1775,U1776" /idTUdmin="U1777" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1970766..1970785) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-10" upshifts complement(1970775) /Source="Nicolas_upshifts" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" CDS complement(1970781..1971164) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate mutase" /protein_id="NP_390150.1" /db_xref="EnsemblGenomes-Gn:BSU22690" /db_xref="EnsemblGenomes-Tr:CAB14185" /db_xref="GOA:P19080" /db_xref="InterPro:IPR008243" /db_xref="InterPro:IPR035959" /db_xref="PDB:1COM" /db_xref="PDB:1DBF" /db_xref="PDB:1FNJ" /db_xref="PDB:1FNK" /db_xref="PDB:2CHS" /db_xref="PDB:2CHT" /db_xref="PDB:3ZO8" /db_xref="PDB:3ZOP" /db_xref="PDB:3ZP4" /db_xref="PDB:3ZP7" /db_xref="SubtiList:BG10286" /db_xref="UniProtKB/Swiss-Prot:P19080" /translation="MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQ MLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQD QIRHVYLEKVVVLRPDLSLTKNTEL*" /label="aroH CDS" gene complement(1970781..1971164) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /label="aroH gene" promotor_-35 complement(1970800..1970807) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-35" CDS complement(1971161..1972249) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /EC_number="4.2.3.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate synthase" /protein_id="NP_390151.1" /db_xref="EnsemblGenomes-Gn:BSU22700" /db_xref="EnsemblGenomes-Tr:CAB14186" /db_xref="GOA:P31102" /db_xref="InterPro:IPR016037" /db_xref="InterPro:IPR030960" /db_xref="InterPro:IPR030963" /db_xref="SubtiList:BG10285" /db_xref="UniProtKB/Swiss-Prot:P31102" /translation="MKTLHVQTASSSYPVFIGQGIRKKACELLTSLNRPLTRIMFVTD EEVDRLYGDEMLHLLQEKWPVKKVTVPSGEQAKSMDMYTKLQSEAIRFHMDRSSCIIA FGGGVVGDLAGFVAATFMRGIDFIQMPTTLLAHDSAVGGKVAVNHPLGKNLIGAFYQP KAVLYDTDFLRSLPEKELRSGMAEVIKHAFIYDRAFLEELLNIHSLRDITNDQLNDMI FKGISIKASVVQQDEKEEGIRAYLNFGHTLGHAVEAEYGYGQITHGDAVALGMQFALY ISEKTVGCEMDRKRLVSWLKSLGYPSQIRKETETSVLLNRMMNDKKTRGGKIQFIVLN ELGKVADHTFSRNELESWLNKWRLEETS*" /label="aroB CDS" gene complement(1971161..1972249) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /label="aroB gene" promotor_-10 complement(1971290..1971305) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(1971303) /Source="Nicolas_upshifts" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(1971318..1971326) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(1972249..1973421) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /EC_number="4.2.3.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 10518299, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 10518299, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate synthase" /protein_id="NP_390152.3" /db_xref="EnsemblGenomes-Gn:BSU22710" /db_xref="EnsemblGenomes-Tr:CAB14187" /db_xref="GOA:P31104" /db_xref="InterPro:IPR000453" /db_xref="InterPro:IPR020541" /db_xref="InterPro:IPR035904" /db_xref="SubtiList:BG10284" /db_xref="UniProtKB/Swiss-Prot:P31104" /translation="MRYLTAGESHGPQLTTIIEGVPAGLYITEEDINFELARRQKGHG RGRRMQIEKDQAKIMSGVRHARTLGSPIALVVENNDWKHWTKIMGAAPITEDEEKEMK RQISRPRPGHADLNGAIKYNHRDMRNVLERSSARETTVRVAAGAVAKKILSELGIKVA GHVLQIGAVKAEKTEYTSIEDLQRVTEESPVRCYDEEAGKKMMAAIDEAKANGDSIGG IVEVIVEGMPVGVGSYVHYDRKLDSKLAAAVLSINAFKGVEFGIGFEAAGRNGSEVHD EIIWDEEKGYTRATNRLGGLEGGMTTGMPIVVRGVMKPIPTLYKPLKSVDIETKEPFS ASIERSDSCAVPAASVVAEAAVAWEIANAVVEQFGLDQIDRIRENVENMRKLSREF*" /label="aroF CDS" gene complement(1972249..1973421) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /label="aroF gene" promotor_-10 complement(1973456..1973475) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1973473) /Source="Nicolas_upshifts" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1973488..1973495) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1973496..1974266) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /EC_number="2.1.1.80" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCPs) methyltransferase" /protein_id="NP_390153.2" /db_xref="EnsemblGenomes-Gn:BSU22720" /db_xref="EnsemblGenomes-Tr:CAB14188" /db_xref="GOA:P31105" /db_xref="InterPro:IPR000780" /db_xref="InterPro:IPR022641" /db_xref="InterPro:IPR022642" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036804" /db_xref="PDB:5FTW" /db_xref="SubtiList:BG10283" /db_xref="UniProtKB/Swiss-Prot:P31105" /translation="MDTYSVFTTKWKQLTGVDLTLYKEAQMKRRLTSLYEKKGFQSFK DFAAALEKDQALLNETLDRMTINVSEFYRNYKRWEVLETAILPLIKTSRPLKIWSAAC STGEEPYTLAMLLDQQKGLPGYQILATDIDEKALEKAKKGVYQERSLQEVPLSVKDRY FTQNANRSYEVKTEIKKNITFKKHNLLADRYEQDFDLIVCRNVFIYFTESAKEELYLK MAHSLKKNGVLFVGSTEQIFNPEKFGLVPADTFFYQKR*" /label="cheR CDS" gene complement(1973496..1974266) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /label="cheR gene" promotor_-10 complement(1974292..1974311) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1974309) /Source="Nicolas_upshifts" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1974323..1974329) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" S_feature complement(1974341..1974502) /Source="Nicolas_S_feature" /locus_tag="new_2381192_2381353_c" /HighExp="M0t90, Lbstat, S0, Mt0, M0t45, M40t90, Lbtran, Mal, G/S, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.996, 0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S858" downshifts complement(1974384) /Source="Nicolas_upshifts" /id="D1185" /incds=0 /nref=26 /ntot=128 /MaxReadThrough="4.04342" /MaxDrop="4.7493" /score="29.2259705" /energy="-8.6" /TU="U1777,U1778,U1779,U1780" /idTUdmin="U1778" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" CDS complement(1974503..1974952) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /EC_number="2.7.4.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 11734624, 22720735, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside diphosphate kinase" /protein_id="NP_390154.1" /db_xref="EnsemblGenomes-Gn:BSU22730" /db_xref="EnsemblGenomes-Tr:CAB14189" /db_xref="GOA:P31103" /db_xref="InterPro:IPR001564" /db_xref="InterPro:IPR023005" /db_xref="InterPro:IPR034907" /db_xref="InterPro:IPR036850" /db_xref="SubtiList:BG10282" /db_xref="UniProtKB/Swiss-Prot:P31103" /translation="MMEKTFIMVKPDGVQRQLIGDILSRFERKGLQLAGAKLMRVTEQ MAEKHYAEHQGKPFFGELVEFITSGPVFAMVWEGENVIEVTRQLIGKTNPKEALPGTI RGDYGMFVGKNIIHGSDSLESAEREINIFFKNEELVSYQQLMAGWIY*" /label="ndk CDS" gene complement(1974503..1974952) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /label="ndk gene" promotor_-10 complement(1974995..1975014) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(1975002) /Source="Nicolas_upshifts" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(1975027..1975034) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(1975068..1976114) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /EC_number="2.5.1.30" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component II" /protein_id="NP_390155.1" /db_xref="EnsemblGenomes-Gn:BSU22740" /db_xref="EnsemblGenomes-Tr:CAB14190" /db_xref="GOA:P31114" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR014119" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG10281" /db_xref="UniProtKB/Swiss-Prot:P31114" /translation="MLNIIRLLAESLPRISDGNENTDVWVNDMKFKMAYSFLNDDIDV IERELEQTVRSDYPLLSEAGLHLLQAGGKRIRPVFVLLSGMFGDYDINKIKYVAVTLE MIHMASLVHDDVIDDAELRRGKPTIKAKWDNRIAMYTGDYMLAGSLEMMTRINEPKAH RILSQTIVEVCLGEIEQIKDKYNMEQNLRTYLRRIKRKTALLIAVSCQLGAIASGADE KIHKALYWFGYYVGMSYQIIDDILDFTSTEEELGKPVGGDLLQGNVTLPVLYALKNPA LKNQLKLINSETTQEQLEPIIEEIKKTDAIEASMAVSEMYLQKAFQKLNTLPRGRARS SLAAIAKYIGKRKF*" /label="hepT CDS" gene complement(1975068..1976114) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /label="hepT gene" CDS complement(1976056..1976757) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /EC_number="2.1.1.163" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16279806, 9045837, 9139683, 21513522, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16279806, 9045837, 9139683, 21513522, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="demethylmenaquinone methyltransferase" /protein_id="NP_390156.1" /db_xref="EnsemblGenomes-Gn:BSU22750" /db_xref="EnsemblGenomes-Tr:CAB14191" /db_xref="GOA:P31113" /db_xref="InterPro:IPR004033" /db_xref="InterPro:IPR014122" /db_xref="InterPro:IPR023576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10280" /db_xref="UniProtKB/Swiss-Prot:P31113" /translation="MQDSKEQRVHGVFEKIYKNYDQMNSVISFQQHKKWRDKTMRIMN VKEGAKALDVCCGTADWTIALAKAAGKSGEIKGLDFSENMLSVGEQKVKDGGFSQIEL LHGNAMELPFDDDTFDYVTIGFGLRNVPDYLTVLKEMRRVVKPGGQVVCLETSQPEMF GFRQAYFMYFKYIMPFFGKLFAKSYKEYSWLQESARDFPGMKELAGLFEEAGLKNVKY HSFTGGVAATHIGWK*" /label="menG CDS" gene complement(1976056..1976757) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /label="menG gene" CDS complement(1976764..1977519) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /EC_number="2.5.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component I" /protein_id="NP_390157.1" /db_xref="EnsemblGenomes-Gn:BSU22760" /db_xref="EnsemblGenomes-Tr:CAB14192" /db_xref="GOA:P31112" /db_xref="InterPro:IPR009920" /db_xref="SubtiList:BG10279" /db_xref="UniProtKB/Swiss-Prot:P31112" /translation="MQDIYGTLANLNTKLKQKLSHPYLAKHISAPKIDEDKLLLFHAL FEEADIKNNDRENYIVTAMLVQSALDTHDEVTTARVIKRDENKNRQLTVLAGDYFSGL YYSLLSEMKDIYMIRTLATAIKEINEHKIRLYDRSFKDENDFFESVGIVESALFHRVA EHFNLPRWKKLSSDFFVFKRLMNGNDAFLDVIGSFIQLGKTKEEILEDCFKKAKNSIE SLLPLNSPIQNILINRLKTISQDQTYHQKVEEG*" /label="hepS CDS" gene complement(1976764..1977519) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /label="hepS gene" S_feature complement(1977520..1977605) /Source="Nicolas_S_feature" /locus_tag="new_2384371_2384456_c" /HighExp="H2O2, G150, G180, Paraq, Oxctl, G135, T-4.40H, Lbexp, T-3.40H, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S859" promotor_-10 complement(1977594..1977613) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1977605) /Source="Nicolas_upshifts" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1977624..1977631) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1977683..1977910) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15099736, 15588817, 16285852, 16306262, 17114058, 28069823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15099736, 15588817, 16285852, 16306262, 17114058, 28069823; Product type r : regulator" /codon_start=1 /transl_table=11 /product="tryptophan operon RNA-binding attenuation protein (TRAP)" /protein_id="NP_390158.1" /db_xref="EnsemblGenomes-Gn:BSU22770" /db_xref="EnsemblGenomes-Tr:CAB14193" /db_xref="GOA:P19466" /db_xref="InterPro:IPR000824" /db_xref="InterPro:IPR016031" /db_xref="InterPro:IPR023558" /db_xref="PDB:1WAP" /db_xref="PDB:3ZZQ" /db_xref="PDB:4B27" /db_xref="SubtiList:BG10278" /db_xref="UniProtKB/Swiss-Prot:P19466" /translation="MNQKHSSDFVVIKAVEDGVNVIGLTRGTDTKFHHSEKLDKGEVI IAQFTEHTSAIKVRGEALIQTAYGEMKSEKK*" /label="mtrB CDS" gene complement(1977683..1977910) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /label="mtrB gene" downshifts complement(1977704) /Source="Nicolas_upshifts" /id="D1186" /incds=0 /nref=22 /ntot=162 /MaxReadThrough="6.02348" /MaxDrop="4.385" /score="8.50521108" /energy="-10.5" /TU="U1779,U1780" /idTUdmin="U1781" /TUdmin=1499 /isTUend="FALSE" /label="downshifts" CDS complement(1977932..1978504) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1551827, 12559918, 14717702, 17032654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1551827, 12559918, 14717702, 17032654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_390159.1" /db_xref="EnsemblGenomes-Gn:BSU22780" /db_xref="EnsemblGenomes-Tr:CAB14194" /db_xref="GOA:P19465" /db_xref="InterPro:IPR001474" /db_xref="InterPro:IPR018234" /db_xref="InterPro:IPR020602" /db_xref="SubtiList:BG10277" /db_xref="UniProtKB/Swiss-Prot:P19465" /translation="MKEVNKEQIEQAVRQILEAIGEDPNREGLLDTPKRVAKMYAEVF SGLNEDPKEHFQTIFGENHEELVLVKDIAFHSMCEHHLVPFYGKAHVAYIPRGGKVTG LSKLARAVEAVAKRPQLQERITSTIAESIVETLDPHGVMVVVEAEHMCMTMRGVRKPG AKTVTSAVRGVFKDDAAARAEVLEHIKRQD*" /label="folEA CDS" gene complement(1977932..1978504) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /label="folEA gene" promotor_-10 complement(1978533..1978552) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1978543) /Source="Nicolas_upshifts" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" S_feature complement(1978545..1978628) /Source="Nicolas_S_feature" /locus_tag="new_2385396_2385479_c" /HighExp="Oxctl, G150, G180, G135, LBGexp, Paraq, LPh, H2O2, aero, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S860" promotor_-35 complement(1978565..1978571) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" downshifts complement(1978673) /Source="Nicolas_upshifts" /id="D1187" /incds=0 /nref=33 /ntot=254 /MaxReadThrough="6.68474" /MaxDrop="5.1938" /score="8.50521108" /energy="-10.5" /TU="U1780" /idTUdmin="U1781" /TUdmin=530 /isTUend="FALSE" /label="downshifts" CDS complement(1978692..1978970) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /function="16.1: Circulate" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617; Product type f: factor" /codon_start=1 /transl_table=11 /product="non-specific DNA-binding protein HBsu" /protein_id="NP_390160.1" /db_xref="EnsemblGenomes-Gn:BSU22790" /db_xref="EnsemblGenomes-Tr:CAB14195" /db_xref="GOA:P08821" /db_xref="InterPro:IPR000119" /db_xref="InterPro:IPR010992" /db_xref="InterPro:IPR020816" /db_xref="SubtiList:BG10276" /db_xref="UniProtKB/Swiss-Prot:P08821" /translation="MNKTELINAVAEASELSKKDATKAVDSVFDTILDALKNGDKIQL IGFGNFEVRERSARKGRNPQTGEEIEIPASKVPAFKPGKALKDAVAGK*" /label="hbs CDS" gene complement(1978692..1978970) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /label="hbs gene" S_feature complement(1978971..1979196) /Source="Nicolas_S_feature" /locus_tag="new_2385822_2386047_c" /HighExp="dia5, C90, T-0.40H, G/S, S1, Salt, Lbexp, dia15, T-1.40H, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S861" promotor_-10 complement(1979178..1979197) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1979196) /Source="Nicolas_upshifts" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1979214..1979219) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1979344..1980822) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11160095, 17114257, 17427285, 24810258, 26387458, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160095, 17114257, 17427285, 24810258, 26387458, 28408070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="morphogenetic stage IV sporulation protein" /protein_id="NP_390161.1" /db_xref="EnsemblGenomes-Gn:BSU22800" /db_xref="EnsemblGenomes-Tr:CAB14196" /db_xref="GOA:P35149" /db_xref="InterPro:IPR014201" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10275" /db_xref="UniProtKB/Swiss-Prot:P35149" /translation="MEKVDIFKDIAERTGGDIYLGVVGAVRTGKSTFIKKFMELVVLP NISNEADRARAQDELPQSAAGKTIMTTEPKFVPNQAMSVHVSDGLDVNIRLVDCVGYT VPGAKGYEDENGPRMINTPWYEEPIPFHEAAEIGTRKVIQEHSTIGVVITTDGTIGDI ARSDYIEAEERVIEELKEVGKPFIMVINSVRPYHPETEAMRQDLSEKYDIPVLAMSVE SMRESDVLSVLREALYEFPVLEVNVNLPSWVMVLKENHWLRESYQESVKETVKDIKRL RDVDRVVGQFSEFEFIESAGLAGIELGQGVAEIDLYAPDHLYDQILKEVVGVEIRGRD HLLELMQDFAHAKTEYDQVSDALKMVKQTGYGIAAPALADMSLDEPEIIRQGSRFGVR LKAVAPSIHMIKVDVESEFAPIIGTEKQSEELVRYLMQDFEDDPLSIWNSDIFGRSLS SIVREGIQAKLSLMPENARYKLKETLERIINEGSGGLIAIIL*" /label="spoIVA CDS" gene complement(1979344..1980822) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /label="spoIVA gene" downshifts complement(1979357) /Source="Nicolas_upshifts" /id="D1188" /incds=0 /nref=59 /ntot=76 /MaxReadThrough="3.43222" /MaxDrop="7.13908" /score="13.6316529" /energy="-9.2" /TU="U1781" /idTUdmin="U1782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1980823..1980984) /Source="Nicolas_S_feature" /locus_tag="new_2387674_2387835_c" /HighExp="S3, S4, S5, S6, LoTm, S7, B36, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S862" promotor_-10 complement(1980971..1980989) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-10" upshifts complement(1980996) /Source="Nicolas_upshifts" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="upshifts" CDS complement(1981003..1981737) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein of unknown function" /protein_id="NP_390162.1" /db_xref="EnsemblGenomes-Gn:BSU22810" /db_xref="EnsemblGenomes-Tr:CAB14197" /db_xref="SubtiList:BG10274" /db_xref="UniProtKB/Swiss-Prot:P39911" /translation="MGKLKCAIIFAAVVFLSGCLYPNERKSSVHAIPYQDQLKQVQSA VDEFQKANGGLLPIQTKDMSTPLYQKYPIDFNRLAPRYIAEPPSTAFESGGDYQYVLV DVENDPTVKLIDLKMAEKIRDVKLRIQMYRQEHQYPPYKDVLSRDLFTLDEKKLGDGS SLTVTSPISGNSLPLMIDGDGEIYADYRTELASCLKKSKKTFKPGTEIQDMIWHETPF VPAFSVKYTVNDKQEPVFLENDMKKE*" /label="yphF CDS" gene complement(1981003..1981737) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /label="yphF gene" promotor_-35 complement(1981004..1981009) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-35" downshifts complement(1981029) /Source="Nicolas_upshifts" /id="D1189" /incds=0 /nref=6 /ntot=78 /MaxReadThrough="6.50932" /MaxDrop="4.759" /score="15.8109079" /energy="-12.7" /TU="U1782" /idTUdmin="U1783" /TUdmin=1100 /isTUend="FALSE" /label="downshifts" CDS complement(1981759..1981962) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390163.1" /db_xref="EnsemblGenomes-Gn:BSU22820" /db_xref="EnsemblGenomes-Tr:CAB14198" /db_xref="GOA:P50744" /db_xref="InterPro:IPR020076" /db_xref="SubtiList:BG11444" /db_xref="UniProtKB/Swiss-Prot:P50744" /translation="MNLALMKMWFALGSMGLMFLAVASIYLSRFKCQNRFLKIAISSF AYMCMLISGIIVFVVVFSGPVNE*" /label="yphE CDS" gene complement(1981759..1981962) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /label="yphE gene" promotor_-10 complement(1981998..1982017) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1982019) /Source="Nicolas_upshifts" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1982031..1982038) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1982084..1982283) /Source="Nicolas_S_feature" /locus_tag="new_2388935_2389134_c" /HighExp="S7, S8, S6, C30, BT, G135, G180, Oxctl, Cold, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, Sig-" /TUshortPSig="1, 1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S863" downshifts complement(1982127) /Source="Nicolas_upshifts" /id="D1190" /incds=0 /nref=264 /ntot=295 /MaxReadThrough="2.22999" /MaxDrop="8.05743" /score="26.216597" /energy="-14.1" /TU="NA" /idTUdmin="U1783" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1982258..1982277) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1982283) /Source="Nicolas_upshifts" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1982291..1982300) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1982300..1983337) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /EC_number="1.1.1.94" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592341, 12682299, 15557260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592341, 12682299, 15557260; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent glycerol-3-phosphate dehydrogenase" /protein_id="NP_390164.1" /db_xref="EnsemblGenomes-Gn:BSU22830" /db_xref="EnsemblGenomes-Tr:CAB14199" /db_xref="GOA:P46919" /db_xref="InterPro:IPR006109" /db_xref="InterPro:IPR006168" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR011128" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11366" /db_xref="UniProtKB/Swiss-Prot:P46919" /translation="MKKVTMLGAGSWGTALALVLTDNGNEVCVWAHRADLIHQINELH ENKDYLPNVKLSTSIKGTTDMKEAVSDADVIIVAVPTKAIREVLRQAVPFITKKAVFV HVSKGIEPDSLLRISEIMEIELPSDVRKDIVVLSGPSHAEEVGLRHPTTVTASSKSMR AAEEVQDLFINHNFRVYTNPDIIGVEIGGALKNIIALAAGITDGLGYGDNAKAALITR GLAEIARLGTKMGGNPLTFSGLTGVGDLIVTCTSVHSRNWRAGNLLGKGYKLEDVLEE MGMVVEGVRTTKAAYQLSKKYDVKMPITEALHQVLFNGQKVETAVESLMARGKTHEME DLVNTFENQVK*" /label="gpsA CDS" gene complement(1982300..1983337) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /label="gpsA gene" CDS complement(1983355..1984665) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /EC_number="3.6.5.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase essential for ribosome 50S subunit assembly (maturation of the 50S subunit central protoberance)" /protein_id="NP_390165.1" /db_xref="EnsemblGenomes-Gn:BSU22840" /db_xref="EnsemblGenomes-Tr:CAB14200" /db_xref="GOA:P50743" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR016484" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031166" /db_xref="InterPro:IPR032859" /db_xref="PDB:2HJG" /db_xref="PDB:4DCS" /db_xref="PDB:4DCT" /db_xref="PDB:4DCU" /db_xref="PDB:4DCV" /db_xref="PDB:4KYU" /db_xref="PDB:5X4B" /db_xref="SubtiList:BG11443" /db_xref="UniProtKB/Swiss-Prot:P50743" /translation="MGKPVVAIVGRPNVGKSTIFNRIAGERISIVEDTPGVTRDRIYS SAEWLNYDFNLIDTGGIDIGDEPFLAQIRQQAEIAMDEADVIIFMVNGREGVTAADEE VAKILYRTKKPVVLAVNKLDNTEMRANIYDFYSLGFGEPYPISGTHGLGLGDLLDAVA EHFKNIPETKYNEEVIQFCLIGRPNVGKSSLVNAMLGEERVIVSNVAGTTRDAVDTSF TYNQQEFVIVDTAGMRKKGKVYETTEKYSVLRALKAIDRSEVVAVVLDGEEGIIEQDK RIAGYAHEAGKAVVIVVNKWDAVDKDESTMKEFEENIRDHFQFLDYAPILFMSALTKK RIHTLMPAIIKASENHSLRVQTNVLNDVIMDAVAMNPTPTHNGSRLKIYYATQVSVKP PSFVVFVNDPELMHFSYERFLENRIRDAFGFEGTPIKIFARARK*" /label="der CDS" gene complement(1983355..1984665) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /label="der gene" S_feature complement(1984666..1984790) /Source="Nicolas_S_feature" /locus_tag="new_2391517_2391641_c" /HighExp="Cold, G180, G150, Oxctl, G135, C30, LBGexp, Paraq, dia0, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S864" promotor_-10 complement(1984776..1984795) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1984790) /Source="Nicolas_upshifts" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1984810..1984813) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1984819..1985013) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097755.1" /db_xref="EnsemblGenomes-Gn:BSU22849" /db_xref="EnsemblGenomes-Tr:CAX52654" /db_xref="UniProtKB/Swiss-Prot:C0H445" /translation="MSESLTKVILSVITTNRNRVAGGAPVFFCNDQKEMELFAKNLEA ILDGIAHRIGDDVYLIVKHF*" /label="ypzH CDS" gene complement(1984819..1985013) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /label="ypzH gene" CDS complement(1985010..1985903) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390166.1" /db_xref="EnsemblGenomes-Gn:BSU22850" /db_xref="EnsemblGenomes-Tr:CAB14201" /db_xref="GOA:P50742" /db_xref="InterPro:IPR025918" /db_xref="SubtiList:BG11442" /db_xref="UniProtKB/Swiss-Prot:P50742" /translation="MSDYIYPIIAGVIAGIATRLYMLKTDYRQYPTYVHGKVIHIALG LIAAGLGAIIMPALLQEEFTAITFLTLAATQFRDVRNMERNTLTQMDSYELVSRGSTY IEGIAIAFESRNYIVIFTALLTTSAYVFLSIWAAVIAAVVCFLLAMKFMSGSVLKDIV DIEYIKPRFDGPGLFVDNIYMMNIGLPEKQELILKHGMGFILTPKNFNSAATIANLGQ RQAILFDVSNVLGVYRDSGEPSLTPIAKRDLNDGRVAVFVLPQIHHPETAVQIISNVP TLENAIRMPTEFIKNQDKVIG*" /label="yphB CDS" gene complement(1985010..1985903) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /label="yphB gene" CDS complement(1985900..1986499) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390167.1" /db_xref="EnsemblGenomes-Gn:BSU22860" /db_xref="EnsemblGenomes-Tr:CAB14202" /db_xref="GOA:P50741" /db_xref="InterPro:IPR014617" /db_xref="SubtiList:BG11441" /db_xref="UniProtKB/Swiss-Prot:P50741" /translation="MEQFYYYWSMWFLWVLTTFIFEKTKRRIAVSVFILTNIILSIHD IALYFSLNAAYLMFFVCGCVYAGYLGMYRFRYIMVYLTLVAAYAFVYLFALYDPVWFI IKPEWAAVILIVLLTASVERNFEKQLVLFVLGMCQGELVYSFVIQKLAGAMAVGGFQW LNACSAGMILLFGISKYEHLASQIGQKSKRSNKGATKMS*" /label="yphA CDS" gene complement(1985900..1986499) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /label="yphA gene" promotor_-35 1986372..1986378 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1986387..1986570 /Source="Nicolas_S_feature" /locus_tag="new_2393238_2393421" /HighExp="S5, S8, S6, S7, BT, S4, ferm, nit, Pyr, G/S" /AntisenseName="yphA" /AntisenseCor="0.73324773408178501" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.6" /TUlongSig="NA" /TUlongPSig="NA" /label="S865" upshifts 1986389 /Source="Nicolas_upshifts" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1986392..1986403 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1986510..1986528) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1986529) /Source="Nicolas_upshifts" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1986544..1986549) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1986577..1986708 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="YP_003097756.2" /db_xref="EnsemblGenomes-Gn:BSU22869" /db_xref="EnsemblGenomes-Tr:CAX52655" /db_xref="InterPro:IPR025414" /db_xref="UniProtKB/Swiss-Prot:C0H446" /translation="MGKDRQEKKLKASGRVESDRDQSIHYDGATSLEQNGRFKKRKS* " /label="ypzI CDS" gene 1986577..1986708 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /label="ypzI gene" downshifts 1986696 /Source="Nicolas_upshifts" /id="D1191" /incds=0 /nref=37 /ntot=122 /MaxReadThrough="0.20384" /MaxDrop="6.94664" /score="3.33160455" /energy="-13.2" /TU="NA" /idTUdmin="U1785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1986751..1987800) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /EC_number="5.3.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12798687, 14745175, 15206931" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12798687, 14745175, 15206931; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl diphosphate isomerase (typeII)" /protein_id="NP_390168.3" /db_xref="EnsemblGenomes-Gn:BSU22870" /db_xref="EnsemblGenomes-Tr:CAB14203" /db_xref="GOA:P50740" /db_xref="InterPro:IPR000262" /db_xref="InterPro:IPR011179" /db_xref="InterPro:IPR013785" /db_xref="PDB:1P0K" /db_xref="PDB:1P0N" /db_xref="SubtiList:BG11440" /db_xref="UniProtKB/Swiss-Prot:P50740" /translation="MTRAERKRQHINHALSIGQKRETGLDDITFVHVSLPDLALEQVD ISTKIGELSSSSPIFINAMTGGGGKLTYEINKSLARAASQAGIPLAVGSQMSALKDPS ERLSYEIVRKENPNGLIFANLGSEATAAQAKEAVEMIGANALQIHLNVIQEIVMPEGD RSFSGALKRIEQICSRVSVPVIVKEVGFGMSKASAGKLYEAGAAAVDIGGYGGTNFSK IENLRRQRQISFFNSWGISTAASLAEIRSEFPASTMIASGGLQDALDVAKAIALGASC TGMAGHFLKALTDSGEEGLLEEIQLILEELKLIMTVLGARTIADLQKAPLVIKGETHH WLTERGVNTSSYSVR*" /label="fni CDS" gene complement(1986751..1987800) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /label="fni gene" downshifts complement(1986771) /Source="Nicolas_upshifts" /id="D1192" /incds=0 /nref=209 /ntot=250 /MaxReadThrough="1.39069" /MaxDrop="4.82362" /score="15.2467448" /energy="-13.2" /TU="NA" /idTUdmin="U1788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1987675) /Source="Nicolas_upshifts" /id="D1193" /incds=1 /nref=45 /ntot=237 /MaxReadThrough="6.15611" /MaxDrop="4.91722" /score="13.2731686" /energy="-15.7" /TU="U1788,U1789,U1790" /idTUdmin="U1788" /TUdmin="-904" /isTUend="FALSE" /label="downshifts" CDS complement(1987813..1988961) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 9862121, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA degradation presenting factor (ribosomal protein S1 homolog)" /protein_id="NP_390169.1" /db_xref="EnsemblGenomes-Gn:BSU22880" /db_xref="EnsemblGenomes-Tr:CAB14204" /db_xref="GOA:P38494" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11005" /db_xref="UniProtKB/Swiss-Prot:P38494" /translation="MTEEMNQIDVQVPEVGDVVKGIVTKVEDKHVDVEIINVKQSGII PISELSSLHVEKASDVVKVDDELDLKVTKVEDDALILSKRAVDADRAWEDLEKKFETK EVFEAEVKDVVKGGLVVDIGVRGFIPASLVEAHFVEDFTDYKGKTLSLLVVELDRDKN RVILSHRAVVESEQANKKQELLQSLEVGSVLDGKVQRLTDFGAFVDIGGIDGLVHISQ LSHSHVEKPSDVVEEGQEVKVKVLSVDRDNERISLSIKDTLPGPWNQIGEKVKPGDVL EGTVQRLVSFGAFVEILPGVEGLVHISQISNKHIGTPHEVLEEGQTVKVKVLDVNENE ERISLSMRELEETPKADQEDYRQYQAKEETSTGFQLGDLIGDKLNKLK*" /label="rpfA CDS" gene complement(1987813..1988961) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /label="rpfA gene" misc_feature 1988142..1988145 /Source="Nicolas_upshift_promotors" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1988169 /Source="Nicolas_upshifts" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1988235 /Source="Nicolas_upshifts" /id="D1194" /incds=1 /nref=1 /ntot=124 /MaxReadThrough="1.88188" /MaxDrop="2.8624" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1988939 /Source="Nicolas_upshifts" /id="D1195" /incds=0 /nref=3 /ntot=200 /MaxReadThrough="1.33117" /MaxDrop="3.08345" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=704 /isTUend="FALSE" /label="downshifts" S_feature complement(1988962..1989101) /Source="Nicolas_S_feature" /locus_tag="new_2395813_2395952_c" /HighExp="C90, Salt, Etha, Lbtran, HiOs, M40t90, S1, LBGtran, LoTm, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.999, 0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S866" promotor_-10 complement(1989100..1989119) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1989101) /Source="Nicolas_upshifts" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1989103..1989193) /Source="Nicolas_S_feature" /locus_tag="new_2395954_2396044_c" /HighExp="G135, G180, LBGexp, C30, Cold, Oxctl, dia0, G150, Paraq, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40511799999999998" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S867" promotor_-35 complement(1989134..1989141) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1989194..1989868) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /EC_number="2.7.4.25" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8576266, 9179491, 9862121, 11827479, 12682299, 16880539" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576266, 9179491, 9862121, 11827479, 12682299, 16880539; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidylate kinase" /protein_id="NP_390170.1" /db_xref="EnsemblGenomes-Gn:BSU22890" /db_xref="EnsemblGenomes-Tr:CAB14205" /db_xref="GOA:P38493" /db_xref="InterPro:IPR003136" /db_xref="InterPro:IPR011994" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11004" /db_xref="UniProtKB/Swiss-Prot:P38493" /translation="MEKKLSIAIDGPAAAGKSTVAKIVAEKKSYIYIDTGAMYRAITY AALQENVDLTDEEKLAELLKRTDIELITTKDGQKVFVNGTDVTEAIRTDEISNQVSIA AKHRSVREEMVKRQQQLGEKGGVVMDGRDIGTHVLPNAEVKIFLLASVEERAKRRYEE NVKKGFDVNYETLIEEIARRDKLDSEREVSPLRKAEDALEIDTTSLSIQEVADKILEA VEQKSR*" /label="cmk CDS" gene complement(1989194..1989868) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /label="cmk gene" S_feature complement(1989869..1989946) /Source="Nicolas_S_feature" /locus_tag="new_2396720_2396797_c" /HighExp="S4, S5, S7, S8, S6, dia15, S3, Diami, dia5, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S868" CDS complement(1989947..1990123) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390171.1" /db_xref="EnsemblGenomes-Gn:BSU22900" /db_xref="EnsemblGenomes-Tr:CAB14206" /db_xref="InterPro:IPR035281" /db_xref="SubtiList:BG11003" /db_xref="UniProtKB/Swiss-Prot:P38492" /translation="MKTFERLLIKLLFIQAIILLGVQFLFHYQHIEPYVSKVIQYEGV DKMEENNRIETFKH*" /label="ypfB CDS" gene complement(1989947..1990123) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /label="ypfB gene" promotor_-10 complement(1990135..1990153) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1990152) /Source="Nicolas_upshifts" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1990168..1990174) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1990168..1990821) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16249258, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16249258, 23893111, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic di-GMP receptor" /protein_id="NP_390172.1" /db_xref="EnsemblGenomes-Gn:BSU22910" /db_xref="EnsemblGenomes-Tr:CAB14207" /db_xref="GOA:P38491" /db_xref="InterPro:IPR009875" /db_xref="InterPro:IPR009926" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG11002" /db_xref="UniProtKB/Swiss-Prot:P38491" /translation="MIEIGENVLLEYIEENELKKAKSKAVSIENNELLIAYPVDVVTG RTVILHNDMEVTVEFVGKDEVPYRFISRIKGKVKDKLQMICLEMPPREKMKRIQRRQY VRTDAVLDVQIQPGNEEEIRTLSYNISAGGIAVVLADGLSFQSGESLRLIIRLPEEEH TRQIETEAVVRRIFNDPKSEKRKMTLEYSEIAAGDQQALLQYCIRRQLNKRRKARME* " /label="dgrA CDS" gene complement(1990168..1990821) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /label="dgrA gene" promotor_-10 complement(1990851..1990870) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1990864) /Source="Nicolas_upshifts" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1990886..1990890) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1990914..1992266) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination membrane component" /protein_id="NP_390173.1" /db_xref="EnsemblGenomes-Gn:BSU22920" /db_xref="EnsemblGenomes-Tr:CAB14208" /db_xref="GOA:P38490" /db_xref="InterPro:IPR014239" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG11001" /db_xref="UniProtKB/Swiss-Prot:P38490" /translation="MIRGILIAVLGIAIVGTGYWGYKEHQEKDAVLLHAENNYQRAFH ELTYQVDQLHDKIGTTLAMNSQKSLSPALIDVWRITSEAHNSVSQLPLTLMPFNKTEE LLSKIGDFSYKTSVRDLDQKPLDKNEYTSLNKLYQQSEDIQNELRHVQHLVMSKNLRW MDVEMALASDEKQSDNTIINSFKTVEKNVGAFSTGTDLGPSFTSTKKEEKGFSHLKGK QISEQEAKQIAERFAPDDNYSIKVVKSGKKTNRDVYSISMKDPDHKAVIYMDITKKGG HPVYLIQNREVKDQKISLNDGSNRALAFLKKNGFETDDLEIDESAQYDKIGVFSYVPV ENKVRMYPEAIRMKVALDDGEVVGFSARDFLTSHRKRTIPKPAITEAEAKSKLNKNVQ VRETRLALITNELGQEVLCYEMLGTIENDTFRMYINAKDGSEEKVEKLKNAEPIYKDL *" /label="sleC CDS" gene complement(1990914..1992266) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /label="sleC gene" downshifts complement(1990929) /Source="Nicolas_upshifts" /id="D1196" /incds=0 /nref=21 /ntot=44 /MaxReadThrough="0.647060000000002" /MaxDrop="5.74199" /score="16.6521528" /energy="-10.1" /TU="NA" /idTUdmin="U1791" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1992301..1993218) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination cortex-lytic enzyme" /protein_id="NP_390174.1" /db_xref="EnsemblGenomes-Gn:BSU22930" /db_xref="EnsemblGenomes-Tr:CAB14209" /db_xref="GOA:P50739" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR011105" /db_xref="InterPro:IPR014224" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11439" /db_xref="UniProtKB/Swiss-Prot:P50739" /translation="MKSKGSIMACLILFSFTITTFINTETISAFSNQVIQRGATGDDV VELQARLQYNGYYNGKIDGVYGWGTYWAVRNFQDQFGLKEVDGLVGAKTKQTLICKSK YYREYVMEQLNKGNTFTHYGKIPLKYQTKPSKAATQKARQQAEARQKQPAEKTTQKPK ANANKQQNNTPAKARKQDAVAANMPGGFSNNDIRLLAQAVYGEARGEPYEGQVAIAAV ILNRLNSPLFPNSVAGVIFEPLAFTAVADGQIYMQPNETAREAVLDAINGWDPSEEAL YYFNPDTATSPWIWGRPQIKRIGKHIFCE*" /label="sleB CDS" gene complement(1992301..1993218) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /label="sleB gene" downshifts complement(1992689) /Source="Nicolas_upshifts" /id="D1197" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.35344" /MaxDrop="4.29326" /score="-3.16364421" /energy="-21.7" /TU="U1791,U1792" /idTUdmin="U1793" /TUdmin=682 /isTUend="FALSE" /label="downshifts" misc_feature complement(1992840..1992847) /Source="Nicolas_upshift_promotors" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1992843) /Source="Nicolas_upshifts" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1993256..1993267) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1993265) /Source="Nicolas_upshifts" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1993281..1993287) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1993357..1994013) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease required for RsiW anti-sigma(W) degradation" /protein_id="NP_390175.1" /db_xref="EnsemblGenomes-Gn:BSU22940" /db_xref="EnsemblGenomes-Tr:CAB14210" /db_xref="GOA:P50738" /db_xref="InterPro:IPR023596" /db_xref="InterPro:IPR026898" /db_xref="SubtiList:BG11438" /db_xref="UniProtKB/Swiss-Prot:P50738" /translation="MFAIISAGIAPGIALLSYFYLKDQYDNEPVHMVLRSFFLGVVLV FPIMFIQYVLEKENVGGGSFFVSFLSSGFLEESLKWFILMISVYPHAHFDEHYDGIVY GASVSLGFATLENILYLIGHGVEHAFVRALLPVSCHALIGVIMGFYLGKARFSADKAR VKWLTLSLVVPSLLHGSYDFILTALSNWIYYMLPFMVFLWWFGLRKAKKARSVNMMQV *" /label="prsW CDS" gene complement(1993357..1994013) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /label="prsW gene" downshifts complement(1993371) /Source="Nicolas_upshifts" /id="D1198" /incds=0 /nref=239 /ntot=262 /MaxReadThrough="0.9181" /MaxDrop="6.61797" /score="-3.16364421" /energy="-21.7" /TU="NA" /idTUdmin="U1793" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1994038..1994057) /Source="Nicolas_upshift_promotors" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1994053) /Source="Nicolas_upshifts" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1994133..1995107) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /EC_number="1.8.-.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacillithiol biosynthesis thiol disulfide oxidoreductase" /protein_id="NP_390176.2" /db_xref="EnsemblGenomes-Gn:BSU22950" /db_xref="EnsemblGenomes-Tr:CAB14211" /db_xref="GOA:P50736" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR023856" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11436" /db_xref="UniProtKB/Swiss-Prot:P50736" /translation="MIQEKAIIIGGGPCGLSAAIHLKQIGIDALVIEKGNVVNSIYNY PTHQTFFSSSEKLEIGDVAFITENRKPVRIQALSYYREVVKRKNIRVNAFEMVRKVTK TQNNTFVIETSKETYTTPYCIIATGYYDHPNYMGVPGEDLPKVFHYFKEGHPYFDKDV VVIGGKNSSVDAALELVKSGARVTVLYRGNEYSPSIKPWILPEFEALVRNGTIRMEFG ACVEKITENEVVFRSGEKELITIKNDFVFAMTGYHPDHQFLEKIGVEIDKETGRPFFN EETMETNVEGVFIAGVIAAGNNANEIFIENGRFHGGHIAAEIAKRENH*" /label="ypdA CDS" gene complement(1994133..1995107) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /label="ypdA gene" downshifts complement(1994141) /Source="Nicolas_upshifts" /id="D1199" /incds=0 /nref=239 /ntot=263 /MaxReadThrough="3.524" /MaxDrop="6.45954" /score="27.4058676" /energy="-12.2" /TU="U1796" /idTUdmin="U1796" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-35 1994961..1994966 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1994982..1995000 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1994992..1995185 /Source="Nicolas_S_feature" /locus_tag="new_2401843_2402036" /HighExp="S8, S6, S7, S4, S5, C30, S3, BT, B36, C90" /AntisenseName="ypdA" /AntisenseCor="-0.487730736536516" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S869" upshifts 1994992 /Source="Nicolas_upshifts" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="upshifts" downshifts 1995143 /Source="Nicolas_upshifts" /id="D1200" /incds=0 /nref=13 /ntot=27 /MaxReadThrough="1.93985" /MaxDrop="5.69954" /score="23.7306175" /energy="-9.3" /TU="NA" /idTUdmin="U1794" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1995216..1996499) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 18326565, 22178969, 22720735, 25610436" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 18326565, 22178969, 22720735, 25610436; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cryptic glutamate dehydrogenase (active after removal of a 9 bp insert)" /protein_id="NP_390177.2" /db_xref="EnsemblGenomes-Gn:BSU22960" /db_xref="EnsemblGenomes-Tr:CAB14212" /db_xref="GOA:P50735" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K8Z" /db_xref="SubtiList:BG11435" /db_xref="UniProtKB/Swiss-Prot:P50735" /translation="MAADRNTGHTEEDKLDVLKSTQTVIHKALEKLGYPEEVYELLKE PMRLLTVKIPVRMDDGSVKIFTGYRAQHNDSVGPTKGGIRFHPNVTEKEVKAVKALSI WMSLKCGIIDLPYGGGKGGIVCDPRDMSFRELERLSRGYVRAISQIVGPTKDVPAPDV FTNSQIMAWMMDEYSRIDEFNSPGFITGKPLVLGGSHGRESATAKGVTICIKEAAKKR GIDIKGARVVVQGFGNAGSYLAKFMHDAGAKVVGISDAYGGLYDPEGLDIDYLLDRRD SFGTVTKLFNDTITNQELLELDCDILVPAAIENQITEENAHNIRAKIVVEAANGPTTL EGTKILSDRDILLVPDVLASAGGVTVSYFEWVQNNQGFYWSEEEVEEKLEKMMVKSFN NIYEMANNRRIDMRLAAYMVGVRKMAEASRFRGWI*" /label="gudB CDS" gene complement(1995216..1996499) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /label="gudB gene" downshifts complement(1995219) /Source="Nicolas_upshifts" /id="D1201" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="7.92262" /MaxDrop="4.04542" /score="18.1400723" /energy="-9.3" /TU="U1796" /idTUdmin="U1797" /TUdmin=1345 /isTUend="FALSE" /label="downshifts" promotor_-35 1995257..1995263 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1995275..1995279 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1995275 /Source="Nicolas_upshifts" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1996542..1996561) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1996563) /Source="Nicolas_upshifts" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1996576..1996583) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1996655..1997239) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914365, 19801546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914365, 19801546; Product type f: factor" /codon_start=1 /transl_table=11 /product="adaptor to ClpC; regulator of competence and sporulation" /protein_id="NP_390178.1" /db_xref="EnsemblGenomes-Gn:BSU22970" /db_xref="EnsemblGenomes-Tr:CAB14213" /db_xref="GOA:P50734" /db_xref="InterPro:IPR008681" /db_xref="PDB:3JTN" /db_xref="PDB:3JTO" /db_xref="SubtiList:BG11434" /db_xref="UniProtKB/Swiss-Prot:P50734" /translation="MRLERLNYNKIKIFLTLDDLTDRGLTKEDLWKDSFKVHQLFKDM MNEANTELGFEANGPIAVEVYSLQAQGMVVIVTKNQDADSEDDEYDDDYIEMQVKLDE SADIIYQFHSFEDIIQLSESLQRIGITGGTVYHYDGQYFLSLEDLGSHTAEGVVAVLA EYGNPTTLTIYRLQEYGKLIMDGNAVETIQTHFS*" /label="mecB CDS" gene complement(1996655..1997239) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /label="mecB gene" downshifts complement(1996657) /Source="Nicolas_upshifts" /id="D1202" /incds=0 /nref=258 /ntot=274 /MaxReadThrough="3.02006" /MaxDrop="7.92719" /score="23.8885529" /energy="-7.1" /TU="U1797" /idTUdmin="U1797" /TUdmin="-93" /isTUend="FALSE" /label="downshifts" S_feature complement(1997240..1997321) /Source="Nicolas_S_feature" /locus_tag="new_2404091_2404172_c" /HighExp="dia5, Diami, Etha, dia15, C90, Salt, LPhT, Heat, MG-0.2, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S870" promotor_-10 complement(1997314..1997333) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-10" upshifts complement(1997321) /Source="Nicolas_upshifts" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="upshifts" promotor_-35 complement(1997347..1997354) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-35" CDS complement(1997398..1998177) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 17434969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390179.1" /db_xref="EnsemblGenomes-Gn:BSU22980" /db_xref="EnsemblGenomes-Tr:CAB14214" /db_xref="GOA:P50733" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11433" /db_xref="UniProtKB/Swiss-Prot:P50733" /translation="MKLSVKIAGVLTVAAAAMTAKMYATAKGNHLKTHTFPLSKMKGK PPLTIFFISDIHKRLIDQDLLEKARSHAPHLVIIGGDLAEGGVPSARIEENIKRLVHF GVPIVFVWGNNDYEVRQHKLYSIFKAHGVITLRNESVPFSYNGHTIAIAGVDDIRMEM DHYEEAIKELDESQLNILVCHNPEIHEQINEDDGIDVILSGHTHGGQIRFGKFGPYEL GKTGIVKNAAYLISNGYGTTKVPLRLGAEPETHIVTLCGPE*" /label="ypbG CDS" gene complement(1997398..1998177) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /label="ypbG gene" promotor_-10 complement(1998203..1998218) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-10" upshifts complement(1998214) /Source="Nicolas_upshifts" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="upshifts" promotor_-35 complement(1998230..1998239) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-35" CDS complement(1998263..1998706) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390180.1" /db_xref="EnsemblGenomes-Gn:BSU22990" /db_xref="EnsemblGenomes-Tr:CAB14215" /db_xref="GOA:P50732" /db_xref="InterPro:IPR020210" /db_xref="SubtiList:BG11432" /db_xref="UniProtKB/Swiss-Prot:P50732" /translation="MESLWNQLDQFTDAPTKQMLQALVKRKQKFENYAAQCRRWRWAS LICLGLLCVMIMIKSPEPQLILQEILSHTFYLFWMLATAFAYCTSYYFKKKEEKSETD FHKLRCEIIQKSTDLWPQPDKWKARESVFHMMKHKYDINLYFESK*" /label="ypbF CDS" gene complement(1998263..1998706) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /label="ypbF gene" downshifts complement(1998280) /Source="Nicolas_upshifts" /id="D1203" /incds=0 /nref=4 /ntot=112 /MaxReadThrough="4.67294" /MaxDrop="3.33254" /score="6.86206051" /energy="-7.5" /TU="U1801" /idTUdmin="U1799" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1998769..1999491) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855244, 22950025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme possibly involved in cell wall turnover" /protein_id="NP_390181.1" /db_xref="EnsemblGenomes-Gn:BSU23000" /db_xref="EnsemblGenomes-Tr:CAB14216" /db_xref="GOA:P50731" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11431" /db_xref="UniProtKB/Swiss-Prot:P50731" /translation="MTNMSRVERRKAQNLYEDQNAALADDYVDDGESLPTRQSVKNQR EQKKKQGKTKTPLFTVLAVIFVFVPVIVLVTLFYLKSHPDNHDDYEDVFIDSSQSKYE VVPKSEDKNDTADTKETALQKESKKEPEDSKPKEQTAADKKQTAVAEKEDSPNKEEAT AAAASSSQSTVQQQEQPAEPVQNVPNRVVKHTVQKKETLYRISMKYYKSRTGEEKIRA YNHLNGNDVYTGQVLDIPLMDE*" /label="ypbE CDS" gene complement(1998769..1999491) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /label="ypbE gene" downshifts complement(1999050) /Source="Nicolas_upshifts" /id="D1204" /incds=1 /nref=4 /ntot=93 /MaxReadThrough="4.30678" /MaxDrop="3.33147" /score="6.86206051" /energy="-7.5" /TU="U1799,U1801" /idTUdmin="U1799" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" CDS complement(1999442..2000011) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390182.1" /db_xref="EnsemblGenomes-Gn:BSU23010" /db_xref="EnsemblGenomes-Tr:CAB14217" /db_xref="GOA:P50730" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG11430" /db_xref="UniProtKB/Swiss-Prot:P50730" /translation="MTQLLIIFAAAAAGLFFFEDVRDVLKLWDIRDMRIIWYGVSIAV IVILADMAVMKWFPSHLYDDGGINKKIFSKRSIPHIIFLTLLIAFAEEMLFRGVLQTH IGLWTASLIFAALHFRYLSKWLLFIMVTAISFLLGLMYEWTGNLFVPMTAHFIIDAVF ACQIRFEHVRRDKHDEHVESREKKSPESL*" /label="ypbD CDS" gene complement(1999442..2000011) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /label="ypbD gene" promotor_-10 complement(1999760..1999778) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1999776) /Source="Nicolas_upshifts" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1999793..1999799) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2000030..2000776 /Source="Nicolas_S_feature" /locus_tag="new_2406881_2407627" /HighExp="S6, S8, S7, C30, BT, S5, C90, Pyr, BC, Sw" /AntisenseName="recQ" /AntisenseCor="-0.47918253719211501" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S871" CDS complement(2000071..2001561) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16385024, 25246477, 26001966, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385024, 25246477, 26001966, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_390183.1" /db_xref="EnsemblGenomes-Gn:BSU23020" /db_xref="EnsemblGenomes-Tr:CAB14218" /db_xref="GOA:P50729" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002464" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11407" /db_xref="UniProtKB/Swiss-Prot:P50729" /translation="MTKLQQTLYQFFGFTSFKKGQQDIIESILSGKDTIAMLPTGGGK SLCYQLPGYMLDGMVLIVSPLLSLMEDQVQQLKARGEKRAAALNSMLNRQERQFVLEH IHRYKFLYLSPEALQSPYVLEKLKSVPISLFVIDEAHCISEWGHDFRPDYSKLGQLRK KLGHPPVLALTATATKETLQDVMNLLELQHAVRHLNSVNRPNIALRVENAADTAEKID RVIQLVENLQGPGIVYCPTRKWAKELAGEIKSKTSSRADFYHGGLESGDRILIQQQFI HNQLDVICCTNAFGMGVDKPDIRYVIHFHLPQTAEAFMQEIGRAGRDGKPSVSILLRA PGDFELQEQIIQMESVTAEEIADVIRVLEKTEERDERRLRDVLLQYGVGETQARMMIH LFMQGKTSVELMKKEISYRMELKLEKMHRVSFLLQRDGCLRQALLTYFDESYEPDDGN LPCCSHCGFDLSLYEQKGERSKMAPLDSWSSELHRIFSLQTVGELN*" /label="recS CDS" gene complement(2000071..2001561) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /label="recS gene" CDS complement(2001554..2002612) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /experiment="publication(s) with functional evidences, PMID:21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21170359; Product type f: factor" /codon_start=1 /transl_table=11 /product="subunit of the platform for genome maintenance machinery" /protein_id="NP_390184.1" /db_xref="EnsemblGenomes-Gn:BSU23030" /db_xref="EnsemblGenomes-Tr:CAB14219" /db_xref="InterPro:IPR008308" /db_xref="InterPro:IPR029491" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11429" /db_xref="UniProtKB/Swiss-Prot:P50728" /translation="MSLNYFDIMVLDCLCKINGERSGSAVFHLFKGKRSSQTIQDAGL FQTAKYFGMAAKCSRSDISASLDKLEKHSYLAPMSESDTYKVTASGAAVLRHALSERP WPVHCHGAHYQQAAGVLWKRLSLLVQVLSHKQQGSRQYIPVTKDHKTLHWVKKYLSRH TDHIEMAKSLFAMLEAHLKKIENKAAQIFVYSLTSHHRIGYTSRQLADTLKEDEWYVY IMFWASVHYFIHSLPECEDALLKDLLSDVHLDNALTESTRKTWQMVKQGFPIQRIAEI RKLKTATIEDHIVEISLHEPAFMINDYVSAEDQLQIAEFAKRMRTNKIKQIRDGLEQR FSYFQIRLALTKQVQQYD*" /label="gmmB CDS" gene complement(2001554..2002612) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /label="gmmB gene" promotor_-35 2001902..2001911 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2001922..2002712 /Source="Nicolas_S_feature" /locus_tag="new_2408773_2409563" /HighExp="S8, S6, S7, S5, BT, B36, Pyr, G/S, B60, nit" /AntisenseName="ypbB" /AntisenseCor="-0.76734368116597995" /AntisenseRegPval="-52.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S872" upshifts 2001922 /Source="Nicolas_upshifts" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2001924..2001943 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2002653..2002672) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2002676) /Source="Nicolas_upshifts" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2002684..2002691) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2002690..2002696 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-35" promotor_-10 2002710..2002729 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-10" S_feature 2002714..2002783 /Source="Nicolas_S_feature" /locus_tag="new_2409565_2409634" /HighExp="S6, S8, S7, S5, BT, B36, C30, Pyr, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="0.991, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S873" upshifts 2002714 /Source="Nicolas_upshifts" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="upshifts" promotor_-35 2002763..2002770 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2002785..2002877 /Source="Nicolas_S_feature" /locus_tag="new_2409636_2409728" /HighExp="LPhT, LBGstat, HPh, C90, LBGtran, C30, Lbtran, Cold, LPh, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.996" /TUlongSig="SigB" /TUlongPSig="0.991" /label="S874" promotor_-10 2002785..2002804 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2002785 /Source="Nicolas_upshifts" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="upshifts" CDS 2002878..2003126 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12538057, 21665975" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12538057, 21665975; Product type c: carrier" /codon_start=1 /transl_table=11 /product="ferredoxin" /protein_id="NP_390185.1" /db_xref="EnsemblGenomes-Gn:BSU23040" /db_xref="EnsemblGenomes-Tr:CAB14220" /db_xref="GOA:P50727" /db_xref="InterPro:IPR001080" /db_xref="InterPro:IPR017896" /db_xref="SubtiList:BG11388" /db_xref="UniProtKB/Swiss-Prot:P50727" /translation="MAKYTIVDKDTCIACGACGAAAPDIYDYDDEGIAFVTLDENKGV VEVPEVLEEDMIDAFEGCPTDSIKVADEPFEGDPLKFE*" /label="fer CDS" gene 2002878..2003126 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /label="fer gene" downshifts 2003110 /Source="Nicolas_upshifts" /id="D1205" /incds=0 /nref=221 /ntot=291 /MaxReadThrough="3.16016" /MaxDrop="8.38074" /score="34.9672707" /energy="-9.9" /TU="U1803" /idTUdmin="U1800" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2003166..2003738) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12456892, 15849754, 16850406, 17693491, 25438558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15849754, 16850406, 17693491, 25438558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="FMN permease" /protein_id="NP_390186.1" /db_xref="EnsemblGenomes-Gn:BSU23050" /db_xref="EnsemblGenomes-Tr:CAB14237" /db_xref="GOA:P50726" /db_xref="InterPro:IPR024529" /db_xref="InterPro:IPR025720" /db_xref="SubtiList:BG11428" /db_xref="UniProtKB/Swiss-Prot:P50726" /translation="MKVKKLVVVSMLSSIAFVLMLLNFPFPGLPDYLKIDFSDVPAII AILIYGPLAGIAVEAIKNVLQYIIQGSMAGVPVGQVANFIAGTLFILPTAFLFKKLNS AKGLAVSLLLGTAAMTILMSILNYVLILPAYTWFLHSPALSDSALKTAVVAGILPFNM IKGIVITVVFSLIFIKLKPWIEQQRSAHIH*" /label="fmnP CDS" gene complement(2003166..2003738) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /label="fmnP gene" downshifts complement(2003186) /Source="Nicolas_upshifts" /id="D1206" /incds=0 /nref=103 /ntot=231 /MaxReadThrough="2.60651" /MaxDrop="4.95518" /score="35.0684207" /energy="-9.9" /TU="NA" /idTUdmin="U1804" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(2003730..2004037) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /product="flavin mononucleotide riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508; Product type n: RNA" /label="fswB RNA" gene complement(2003730..2004037) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /label="fswB gene" S_feature complement(2003739..2003843) /Source="Nicolas_S_feature" /locus_tag="new_2410590_2410694_c" /HighExp="S1, LPhT, M9-stat, B60, Heat, T0.30H, Gly, S5, BC, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S875" promotor_-10 complement(2004036..2004055) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2004052) /Source="Nicolas_upshifts" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2004069..2004075) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2004164..2004171 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2004182 /Source="Nicolas_upshifts" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2004186..2004205 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2004235..2005812 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /EC_number="1.1.1.95" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoglycerate dehydrogenase" /protein_id="NP_390188.2" /db_xref="EnsemblGenomes-Gn:BSU23070" /db_xref="EnsemblGenomes-Tr:CAB14239" /db_xref="GOA:P35136" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR006236" /db_xref="InterPro:IPR029009" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10509" /db_xref="UniProtKB/Swiss-Prot:P35136" /translation="MFRVLVSDKMSNDGLQPLIESDFIEIVQKNVADAEDELHTFDAL LVRSATKVTEDLFNKMTSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEH TFAMISSLMRHIPQANISVKSREWNRTAYVGSELYGKTLGIVGLGRIGSEIAQRARAF GMTVHVFDPFLTEERAKKIGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKT KKGVRLINCARGGIIDEAALLEALENGHVAGAALDVFEVEPPVDNKLVDHPLVIATPH LGASTKEAQLNVAAQVSEEVLQFAKGLPVMSAINLPAMTKDEFAKIKPYHQIAGKIGS LVSQCMKEPVQDVAIQYEGTIAKLETSFITKALLSGFLKPRVDSTVNEVNAGGVAKER GISFSEKISSSESGYDNCISVKVTGDRSTFTVTATYIPHFGERIVEINGFNIDFYPTG HLVYIQHQDTTGVIGRVGRILGDNDINIATMQVGRKEKGGEAIMMLSFDRHLEDKIVK ELTNVPDIVSVKLIDLP*" /label="serA CDS" gene 2004235..2005812 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /label="serA gene" downshifts 2005794 /Source="Nicolas_upshifts" /id="D1207" /incds=0 /nref=246 /ntot=311 /MaxReadThrough="3.23011" /MaxDrop="8.29454" /score="32.0086708" /energy="-10.2" /TU="U1805" /idTUdmin="U1805" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS complement(2005855..2006622) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6442253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6442253; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase" /protein_id="NP_390189.1" /db_xref="EnsemblGenomes-Gn:BSU23080" /db_xref="EnsemblGenomes-Tr:CAB14240" /db_xref="GOA:P35146" /db_xref="InterPro:IPR001381" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018508" /db_xref="SubtiList:BG10538" /db_xref="UniProtKB/Swiss-Prot:P35146" /translation="MNVLTIKGVSIGEGMPKIIIPLMGKTEKQILNEAEAVKLLNPDI VEWRVDVFEKANDREAVTKLISKLRKSLEDKLFLFTFRTHKEGGSMEMDESSYLALLE SAIQTKDIDLIDIELFSGDANVKALVSLAEENNVYVVMSNHDFEKTPVKDEIISRLRK MQDLGAHIPKMAVMPNDTGDLLTLLDATYTMKTIYADRPIITMSMAATGLISRLSGEV FGSACTFGAGEEASAPGQIPVSELRSVLDILHKNTRG*" /label="aroC CDS" gene complement(2005855..2006622) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /label="aroC gene" downshifts complement(2005870) /Source="Nicolas_upshifts" /id="D1208" /incds=0 /nref=152 /ntot=231 /MaxReadThrough="2.53428" /MaxDrop="5.12103" /score="24.3727755" /energy="-10.2" /TU="NA" /idTUdmin="U1806" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 2006124..2006736 /Source="Nicolas_S_feature" /locus_tag="new_2412975_2413587" /HighExp="B36, C30, LoTm, B60, C90, HiOs, BI, Sw, T1.0H, BT" /AntisenseName="aroC" /AntisenseCor="4.7354591214804703E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S876" promotor_-10 complement(2006649..2006668) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2006662) /Source="Nicolas_upshifts" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2006683..2006686) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2006696 /Source="Nicolas_upshifts" /id="D1209" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="2.02363" /MaxDrop="5.64228" /score="10.7892325" /energy="-8.5" /TU="NA" /idTUdmin="U1805" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS complement(2006734..2007840) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9139908, 9393439, 10712692, 14762009, 16306698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139908, 9393439, 10712692, 14762009, 16306698; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma(X) activity" /protein_id="NP_390190.2" /db_xref="EnsemblGenomes-Gn:BSU23090" /db_xref="EnsemblGenomes-Tr:CAB14241" /db_xref="GOA:P35166" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10537" /db_xref="UniProtKB/Swiss-Prot:P35166" /translation="MMKSEWNEEQIKELLSQLPAVKDHRSPQDIYKRLTMAKRKNKPA VRWIGPACAAAIAVYIAFIISPHFFDQAQPQQKEASQENAVTKTETEDSPKAASSLDQ TSFVVPEKEQDNYITVAVADADTSAIIPVSIQKTNADQTIQDMLFESSELGILDHAIT IPTFIDEVEIKEKPKQKELSIRVHQPATAFSIKDDTLLKKLLKESLKWSPYEKVKFLS DQNETGVRIGSYGTFTEISIPKQSKRSYYLYQNKQGQDFLVPSNHSFDTVKEAIKEME SSSQEDTTPLIQAGAVQSVTKKQKHLYIRFSKESEVDDSIAGILMIEGLLLTAKEFGF TEVTFTETRTKKIGKYDISDAIPVPAAPNPISLN*" /label="rsiX CDS" gene complement(2006734..2007840) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /label="rsiX gene" downshifts complement(2006751) /Source="Nicolas_upshifts" /id="D1210" /incds=0 /nref=155 /ntot=242 /MaxReadThrough="3.84557" /MaxDrop="5.30684" /score="7.9467954" /energy="-6.7" /TU="U1809" /idTUdmin="U1806" /TUdmin="-881" /isTUend="FALSE" /label="downshifts" CDS complement(2007776..2008360) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9636707, 11222589, 12399481, 14762009, 19767430, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9636707, 11222589, 12399481, 14762009, 19767430, 27965645; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor sigma(X)" /protein_id="NP_390191.2" /db_xref="EnsemblGenomes-Gn:BSU23100" /db_xref="EnsemblGenomes-Tr:CAB14242" /db_xref="GOA:P35165" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10536" /db_xref="UniProtKB/Swiss-Prot:P35165" /translation="MEETFQLLYDTYHQDLYQFLFYMVKDKNQTEDLLQEVYIRVLNS YHTFEGRSSEKTWLLSIARHVAIDWFRKQQTIRQRILGTFDWDTQDVRDQQLLPDELA VQHENVREIYAALDQCTIDQRAVIILRFIQGYSIQETAKALRFSESKVKTTQHRGLKV LRKHMELLREELMDDEVRMERRTDKGVVKSTSGS*" /label="sigX CDS" gene complement(2007776..2008360) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /label="sigX gene" promotor_-35 2008154..2008159 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2008170 /Source="Nicolas_upshifts" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2008174..2008178 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2008311..2008316 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2008328 /Source="Nicolas_upshifts" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2008332..2008350 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2008368 /Source="Nicolas_upshifts" /id="D1211" /incds=0 /nref=8 /ntot=81 /MaxReadThrough="5.89234" /MaxDrop="4.38483" /score="6.57298987" /energy="-13.5" /TU="U1808" /idTUdmin="U1807" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2008409..2008428) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2008413..2008520 /Source="Nicolas_S_feature" /locus_tag="new_2415264_2415371" /HighExp="S4, S8, S6, S7, C30, S3, LoTm, B60, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S877" upshifts complement(2008417) /Source="Nicolas_upshifts" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2008441..2008448) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2008476 /Source="Nicolas_upshifts" /id="D1212" /incds=0 /nref=12 /ntot=64 /MaxReadThrough="2.08559" /MaxDrop="4.36303" /score="6.57298987" /energy="-13.5" /TU="NA" /idTUdmin="U1808" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(2008505..2008563) /Source="Nicolas_S_feature" /locus_tag="new_2415356_2415414_c" /HighExp="Lbstat, BI, nit, S0, M40t90, Lbtran, M0t90, G135, Sw, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S878" downshifts complement(2008536) /Source="Nicolas_upshifts" /id="D1213" /incds=0 /nref=156 /ntot=252 /MaxReadThrough="2.62215" /MaxDrop="6.99198" /score="33.3049318" /energy="-13.5" /TU="NA" /idTUdmin="U1810" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2008564..2010333) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase (ResD / ResE)" /protein_id="NP_390192.1" /db_xref="EnsemblGenomes-Gn:BSU23110" /db_xref="EnsemblGenomes-Tr:CAB14243" /db_xref="GOA:P35164" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4ZR7" /db_xref="SubtiList:BG10535" /db_xref="UniProtKB/Swiss-Prot:P35164" /translation="MKFWKSVVGKLWFTILSLVLIVLFILTVLLLEFIENYHVEEAEN DLTQLANKVAVILENHEDQALARSITWELADNLTSIAIIQDEKNHWYSPNDKNRLSSI TVEQIQHDKDLNKALKDHKKVSKRTGLSDTDTDNERLIVGVPYEKDGKKGMVFLSQSL LAVKDTTKHTTRYIFLAAGIAIVLTTFFAFFLSSRVTYPLRKMREGAQDLAKGKFDTK IPILTQDEIGELATAFNQMGRQLNFHINALNQEKEQLSNILSSMADGVITINIDGTIL VTNPPAERFLQAWYYEQNMNIKEGDNLPPEAKELFQNAVSTEKEQMIEMTLQGRSWVL LMSPLYAESHVRGAVAVLRDMTEERRLDKLREDFIANVSHELRTPISMLQGYSEAIVD DIASSEEDRKEIAQIIYDESLRMGRLVNDLLDLARMESGHTGLHYEKINVNEFLEKII RKFSGVAKEKNIALDHDISLTEEEFMFDEDKMEQVFTNLIDNALRHTSAGGSVSISVH SVKDGLKIDIKDSGSGIPEEDLPFIFERFYKADKARTRGRAGTGLGLAIVKNIVEAHN GSITVHSRIDKGTTFSFYIPTKR*" /label="resE CDS" gene complement(2008564..2010333) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /label="resE gene" downshifts complement(2008620) /Source="Nicolas_upshifts" /id="D1214" /incds=0 /nref=5 /ntot=13 /MaxReadThrough="7.56028" /MaxDrop="3.58685" /score="33.3049318" /energy="-13.5" /TU="U1810,U1811,U1812" /idTUdmin="U1810" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2010330..2011052) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator (ResD / ResE)" /protein_id="NP_390193.2" /db_xref="EnsemblGenomes-Gn:BSU23120" /db_xref="EnsemblGenomes-Tr:CAB14244" /db_xref="GOA:P35163" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10534" /db_xref="UniProtKB/Swiss-Prot:P35163" /translation="MDQTNETKILVVDDEARIRRLLRMYLERENYAIDEAENGDEAIA KGLEANYDLILLDLMMPGTDGIEVCRQIREKKATPIIMLTAKGEEANRVQGFEAGTDD YIVKPFSPREVVLRVKALLRRASQTSYFNANTPTKNVLVFSHLSIDHDAHRVTADGTE VSLTPKEYELLYFLAKTPDKVYDREKLLKEVWQYEFFGDLRTVDTHVKRLREKLNKVS PEAAKKIVTVWGVGYKFEVGAE*" /label="resD CDS" gene complement(2010330..2011052) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /label="resD gene" S_feature complement(2011053..2011132) /Source="Nicolas_S_feature" /locus_tag="new_2417904_2417983_c" /HighExp="Lbstat, M0t90, ferm, M40t90, S2, S0, nit, M40t45, BI, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S879" CDS complement(2011133..2012308) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10844653, 12682299, 15849754, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844653, 12682299, 15849754, 16850406, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390194.2" /db_xref="EnsemblGenomes-Gn:BSU23130" /db_xref="EnsemblGenomes-Tr:CAB14245" /db_xref="GOA:P35162" /db_xref="InterPro:IPR002541" /db_xref="InterPro:IPR017562" /db_xref="SubtiList:BG10533" /db_xref="UniProtKB/Swiss-Prot:P35162" /translation="MAELSGNFLYAAFLVYLIAVPIFGGAIRGNKDKKGRPNRWANIG ITLSIVGFFCHLGYFITRWAASGHAPVSNMFEFTTAFGMMLVLAFIILYFLYRLPSLG LFTLSIALLLIAYASMFPTDISPLIPSLQSNWLYIHVTTAALGQAILAISFVAGVIFL LKHVDQTKPSKKTFWLEAIMFILVTTVAFIAITSAFRLAGYEAEFNWVDKSKEKSVMV YEMPALVGPHQGELLTEGRMEPLVDLPALFSGRKVNTVIWSFGAGLVLYGALRLIIRK RISALLHPLVKNVNLDLVDEVGYRAVSIGFPIFTLGALIFAMIWAQLAWTRFWGWDPK EVWALITFLFYAAYLHLRLSRGWHGEKSAWLAVIGFAIIMFNLIFVNLVLAGLHSYA* " /label="resC CDS" gene complement(2011133..2012308) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /label="resC gene" CDS complement(2012328..2013956) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9395519, 10844653, 12682299, 16825793, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9395519, 10844653, 12682299, 16825793, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390195.1" /db_xref="EnsemblGenomes-Gn:BSU23140" /db_xref="EnsemblGenomes-Tr:CAB14246" /db_xref="GOA:P35161" /db_xref="InterPro:IPR007816" /db_xref="SubtiList:BG10532" /db_xref="UniProtKB/Swiss-Prot:P35161" /translation="MKQVKCECGHINPVGTVLCESCGRALQETQPPLADMRYDGSARR SQTYNKTIIDKIWNFFSSVKVGIWLIVITLAASAFGTIFPQEAYLPPGAQADTYYKEQ YGTFGQLYYLLGFHHLYGSWWYLLLIASIGISLVICSLDRVIPLYRALKNQGVRRSPA FLRRQRLFSETVTVLNGESKEKIVTLLKKKHYRIREKEGSILAEKGRFSRWGPYVNHI GLIIFLIGAMLRFVPGMYVDETLWVREGETAAIPGTDGKYYLKNNQFSVETYNSKTEK KVFADAIDRVGDGRVAKNFQTDAVLYKREGKIVYGEKPKLEKVTEEDIRVNQPLRFDS FSVYQVDYKENQLDQMVFQLIDKKTKKSFGSLKINLLDPDSVYDLGNGYKVEIASYLP DFYFNQDGEPSTKTKIPNNPAFVFNIITPDKPKGEKSFVAIQETIEGSGNNKYKLKFD HVETKNITGLTVRKDLTLWVLAVGGAIFMIGVIQGMYWQHRRIWLHSQDGAVMVAGHT NKNWFGLKKDLAFILADSGLTEPVDQKELIKTQK*" /label="resB CDS" gene complement(2012328..2013956) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /label="resB gene" CDS complement(2013953..2014492) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracytoplasmic thioredoxin involved in cytochrome c maturation (lipoprotein)" /protein_id="NP_390196.2" /db_xref="EnsemblGenomes-Gn:BSU23150" /db_xref="EnsemblGenomes-Tr:CAB14247" /db_xref="GOA:P35160" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR023555" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ST9" /db_xref="PDB:1SU9" /db_xref="PDB:2F9S" /db_xref="PDB:2H19" /db_xref="PDB:2H1A" /db_xref="PDB:2H1B" /db_xref="PDB:2H1D" /db_xref="PDB:2H1G" /db_xref="PDB:3C71" /db_xref="PDB:3C73" /db_xref="SubtiList:BG10531" /db_xref="UniProtKB/Swiss-Prot:P35160" /translation="MKKKRRLFIRTGILLVLICALGYTIYNAVFAGKESISEGSDAPN FVLEDTNGKRIELSDLKGKGVFLNFWGTWCEPCKKEFPYMANQYKHFKSQGVEIVAVN VGESKIAVHNFMKSYGVNFPVVLDTDRQVLDAYDVSPLPTTFLINPEGKVVKVVTGTM TESMIHDYMNLIKPGETSG*" /label="resA CDS" gene complement(2013953..2014492) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /label="resA gene" S_feature complement(2014493..2014586) /Source="Nicolas_S_feature" /locus_tag="new_2421344_2421437_c" /HighExp="LBGtran, LBGstat, G180, Oxctl, H2O2, G150, M0t90, G135, Paraq, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S880" CDS complement(2014587..2015321) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /EC_number="4.2.1.70" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9888802, 24214967" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888802, 24214967; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA pseudouridine 2633 (=2605 standard) pseudouridine synthase" /protein_id="NP_390197.2" /db_xref="EnsemblGenomes-Gn:BSU23160" /db_xref="EnsemblGenomes-Tr:CAB14248" /db_xref="GOA:P35159" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10530" /db_xref="UniProtKB/Swiss-Prot:P35159" /translation="MERLQKVIAHAGVASRRKAEELIKEGKVKVNGKVVTELGVKVTG SDQIEVNGLKVEREEPVYFLLYKPRGVISAAQDDKGRKVVTDFFKNIPQRIYPIGRLD YDTSGLLLLTNDGEFANKLMHPKYEIDKTYVAKVKGIPPKELLRKLERGIRLEEGKTA PAKAKLLSLDKKKQTSIIQLTIHEGRNRQVRRMFEAIGHEVIKLKREEYAFLNLRGLH TGDARELTPHEVKRLRALADHGKNAF*" /label="rluB CDS" gene complement(2014587..2015321) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /label="rluB gene" promotor_-10 complement(2015330..2015349) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2015353) /Source="Nicolas_upshifts" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2015364..2015368) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2015413..2015949) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390198.2" /db_xref="EnsemblGenomes-Gn:BSU23170" /db_xref="EnsemblGenomes-Tr:CAB14249" /db_xref="GOA:P35158" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10529" /db_xref="UniProtKB/Swiss-Prot:P35158" /translation="MEIINWLSLAMIPIIIAGILLYGTIKKVPTYESFVEGGKEGIEI AFSIIPYLVGMLVAITVFRSSGALDFIMDLLKPAFSAIGIPAEVVPLALIRPISGTAA LGMTTDLIAVYGPDSFIGRLASVMQGSTDTTLYVLTVYFGAVGIKKMGDALKVGLLAD LIGVVASIIIVTLLFGSA*" /label="spmB CDS" gene complement(2015413..2015949) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /label="spmB gene" promotor_-10 complement(2015418..2015437) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2015422) /Source="Nicolas_upshifts" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2015452..2015459) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2015954..2016544) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390199.1" /db_xref="EnsemblGenomes-Gn:BSU23180" /db_xref="EnsemblGenomes-Tr:CAB14250" /db_xref="GOA:P35157" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10528" /db_xref="UniProtKB/Swiss-Prot:P35157" /translation="MVNIIWVSLTVIGLVFAMCNGTLQDVNEAVFKGAKEAITISFGL MSVLVFWLGLMKIAEQSGLLDIFSRMCRPFISKLFPDIPPDHPAMGYILSNLMANFFG LGNAATPLGIKAMEQMKKLNGNRSEASRSMITFLAVNTSCITLIPTTVIAVRMAYSSK TPTDIVGPSILATLISGIGAIIIDRYFYYRRKKKGR*" /label="spmA CDS" gene complement(2015954..2016544) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /label="spmA gene" CDS complement(2016532..2017680) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /EC_number="3.4.16.4" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 8892816, 9864321, 10498740, 18266856, 19542328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 8892816, 9864321, 10498740, 18266856, 19542328; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5*) (required for spore cortex)" /protein_id="NP_390200.1" /db_xref="EnsemblGenomes-Gn:BSU23190" /db_xref="EnsemblGenomes-Tr:CAB14251" /db_xref="GOA:P35150" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR018044" /db_xref="PDB:3MFD" /db_xref="SubtiList:BG10527" /db_xref="UniProtKB/Swiss-Prot:P35150" /translation="MRIFKKAVFVIMISFLIATVNVNTAHAAIDVSAKSAIIIDGASG RVLYAKDEHQKRRIASITKIMTAVLAIESGKMDQTVTVSANAVRTEGSAIYLTEGQKV KLKDLVYGLMLRSGNDAAVAIAEHVGGSLDGFVYMMNQKAEQLGMKNTRFQNPHGLDD HENHYSTAYDMAILTKYAMKLKDYQKISGTKIYKAETMESVWKNKNKLLTMLYPYSTG GKTGYTKLAKRTLVSTASKDGIDLIAVTINDPNDWDDHMKMFNYVFEHYQTYLIAKKG DIPKLKGTFYESKAFIKRDITYLLTEEEKENVKINTTLLKPKKAWEKDASKIPDIVGH MEIMFNDATIAKVPIYYENERHQKPKKQFFETFKSIFLNAAGGAKWSI*" /label="dacB CDS" gene complement(2016532..2017680) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /label="dacB gene" promotor_-10 complement(2017702..2017720) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2017709) /Source="Nicolas_upshifts" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2017735..2017740) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2017803..2018342) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12065423" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390201.1" /db_xref="EnsemblGenomes-Gn:BSU23200" /db_xref="EnsemblGenomes-Tr:CAB14252" /db_xref="InterPro:IPR025013" /db_xref="SubtiList:BG10526" /db_xref="UniProtKB/Swiss-Prot:P35156" /translation="MKEAKCERQIHEGKIPNEMGHSIVRAQTQKTGEFLSMVVNTVND YLNQTTLESLQAELPIEKGYCCDVLSTLRRMAVFCEGGAEACRRLLMQEPFQEARAEK TLYNVYHQCIEEFFMPKKDTWCENSRASYTGVSAIEFYHAVPASLEQLLLPLSAAFLK MREELAHYEASGSSMAPIR*" /label="ypuI CDS" gene complement(2017803..2018342) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /label="ypuI gene" downshifts complement(2017816) /Source="Nicolas_upshifts" /id="D1215" /incds=0 /nref=219 /ntot=260 /MaxReadThrough="1.63638" /MaxDrop="8.00748" /score="36.7302977" /energy="-12.2" /TU="NA" /idTUdmin="U1813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2018351..2018368) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2018366) /Source="Nicolas_upshifts" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2018383..2018388) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2018397..2018990) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation factor" /protein_id="NP_390202.1" /db_xref="EnsemblGenomes-Gn:BSU23210" /db_xref="EnsemblGenomes-Tr:CAB14253" /db_xref="GOA:P35155" /db_xref="InterPro:IPR005234" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10525" /db_xref="UniProtKB/Swiss-Prot:P35155" /translation="MGLDIVNWKAIVEALLYAAGDEGLTKKQLLTVLEIEEPELNTIM ADVADEYRGDTRGIELIEYADTYMLSTKKDFAPYLKKLIEVPSKGLSQASLEVLAIVS YKQPITRAEIEEIRGVKSERILHSLVAKALLCEVGRADGPGRAILYGTTPTFLEQFGL KTLDELPPLPENAEEDVLQEEADLFFENFNQTFEDIK*" /label="spcB CDS" gene complement(2018397..2018990) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /label="spcB gene" CDS complement(2018980..2019735) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and partitioning factor" /protein_id="NP_390203.1" /db_xref="EnsemblGenomes-Gn:BSU23220" /db_xref="EnsemblGenomes-Tr:CAB14254" /db_xref="GOA:P35154" /db_xref="InterPro:IPR003768" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG10524" /db_xref="UniProtKB/Swiss-Prot:P35154" /translation="MEEYQVKIDTFEGPLDLLLHLINRLEIDIYDIPVAKITEQYLLY VHTMRVLELDIASEYLVMAATLLSIKSRMLLPKQEEELFEDELLEEEDPREELIEKLI EYRKYKDAAKDLKEREEERQKSFTKPPSDLSEYAKEVKQSEQKLSVTVYDMIGAFQKV LKRKKINRPMETTITRQDIPIEARMNEIVHSLKSRGTRINFMDLFPYEQKEHLVVTFL AVLELMKNQLVLIEQEHNFSDIYITGSESIHGA*" /label="scpA CDS" gene complement(2018980..2019735) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /label="scpA gene" promotor_-35 2019579..2019588 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2019601..2019620 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2019610 /Source="Nicolas_upshifts" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2019781..2019800) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2019796) /Source="Nicolas_upshifts" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2019814..2019821) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2019961..2019968 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2019979..2019998 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2019984 /Source="Nicolas_upshifts" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="upshifts" CDS 2020016..2020540 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390204.1" /db_xref="EnsemblGenomes-Gn:BSU23230" /db_xref="EnsemblGenomes-Tr:CAB14255" /db_xref="InterPro:IPR005500" /db_xref="InterPro:IPR023203" /db_xref="SubtiList:BG10523" /db_xref="UniProtKB/Swiss-Prot:P17617" /translation="MYPKAYIDYLVEFHATRDYFECHEILEEYWKEDPPKKRKRYWVG FIQLAVALYHHRRQNTAGAKRLMANSIRILQAEHRAVEDLGLDHGRLLELMQSVYEQI ETVSAYKSIILPIKDEKLEEACRIECRKKKYTWGQPSALSNIFLIDKHRLRDRTDVIR EREKEIERRKKSRD*" /label="ypuF CDS" gene 2020016..2020540 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /label="ypuF gene" CDS complement(2020554..2020928) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15466513, 25349719; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative riboflavin synthesis-related N-acetyltransferase" /protein_id="NP_390205.1" /db_xref="EnsemblGenomes-Gn:BSU23240" /db_xref="EnsemblGenomes-Tr:CAB14256" /db_xref="GOA:P17622" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10522" /db_xref="UniProtKB/Swiss-Prot:P17622" /translation="MLIRYKKSFEKIAMGLLSFMPNEKDLKQLQQTIKDYETDTDRQL FLWKEDEDIVGAIGVEKKDSEVEIRHISVNPSHRHQGIGKQMMDALKHLFKTQVLVPN ELTQSFFERCQGQQDQDISYNN*" /label="ypzK CDS" gene complement(2020554..2020928) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /label="ypzK gene" downshifts complement(2020570) /Source="Nicolas_upshifts" /id="D1216" /incds=0 /nref=264 /ntot=275 /MaxReadThrough="1.34496" /MaxDrop="8.09525" /score="39.5464967" /energy="-14.3" /TU="NA" /idTUdmin="U1817" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2020990..2021009) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2021002) /Source="Nicolas_upshifts" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2021021..2021028) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2021041..2021505) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /EC_number="2.5.1.78" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3100522, 7473709, 10881048, 12456892, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3100522, 7473709, 10881048, 12456892, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6,7-dimethyl-8-ribityllumazine synthase, beta subunit" /protein_id="NP_390206.1" /db_xref="EnsemblGenomes-Gn:BSU23250" /db_xref="EnsemblGenomes-Tr:CAB14257" /db_xref="GOA:P11998" /db_xref="InterPro:IPR002180" /db_xref="InterPro:IPR034964" /db_xref="InterPro:IPR036467" /db_xref="PDB:1RVV" /db_xref="PDB:1ZIS" /db_xref="SubtiList:BG10521" /db_xref="UniProtKB/Swiss-Prot:P11998" /translation="MNIIQGNLVGTGLKIGIVVGRFNDFITSKLLSGAEDALLRHGVD TNDIDVAWVPGAFEIPFAAKKMAETKKYDAIITLGTVIRGATTHYDYVCNEAAKGIAQ AANTTGVPVIFGIVTTENIEQAIERAGTKAGNKGVDCAVSAIEMANLNRSFE*" /label="ribH CDS" gene complement(2021041..2021505) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /label="ribH gene" promotor_-35 2021376..2021380 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2021394..2021398 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2021397 /Source="Nicolas_upshifts" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2021538..2022734) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /EC_number="3.5.4.25" /EC_number="4.1.99.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9297088, 9515916, 12456892, 19583770, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9297088, 9515916, 12456892, 19583770, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused 3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II" /protein_id="NP_390207.1" /db_xref="EnsemblGenomes-Gn:BSU23260" /db_xref="EnsemblGenomes-Tr:CAB14258" /db_xref="GOA:P17620" /db_xref="InterPro:IPR000422" /db_xref="InterPro:IPR000926" /db_xref="InterPro:IPR016299" /db_xref="InterPro:IPR017945" /db_xref="InterPro:IPR032677" /db_xref="InterPro:IPR036144" /db_xref="SubtiList:BG10520" /db_xref="UniProtKB/Swiss-Prot:P17620" /translation="MFHPIEEALDALKKGEVIIVVDDEDRENEGDFVALAEHATPEVI NFMATHGRGLICTPLSEEIADRLDLHPMVEHNTDSHHTAFTVSIDHRETKTGISAQER SFTVQALLDSKSVPSDFQRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACGSPGAGVI CEIMNEDGTMARVPELIEIAKKHQLKMITIKDLIQYRYNLTTLVEREVDITLPTDFGT FKVYGYTNEVDGKEHVAFVMGDVPFGEEPVLVRVHSECLTGDVFGSHRCDCGPQLHAA LNQIAAEGRGVLLYLRQEGRGIGLINKLKAYKLQEQGYDTVEANEALGFLPDLRNYGI GAQILRDLGVRNMKLLTNNPRKIAGLEGYGLSISERVPLQMEAKEHNKKYLQTKMNKL GHLLHF*" /label="ribBA CDS" gene complement(2021538..2022734) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /label="ribBA gene" CDS complement(2022749..2023396) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /EC_number="2.5.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2106516, 12456892" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2106516, 12456892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="riboflavin synthase (alpha subunit)" /protein_id="NP_390208.1" /db_xref="EnsemblGenomes-Gn:BSU23270" /db_xref="EnsemblGenomes-Tr:CAB14259" /db_xref="GOA:P16440" /db_xref="InterPro:IPR001783" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR026017" /db_xref="SubtiList:BG10519" /db_xref="UniProtKB/Swiss-Prot:P16440" /translation="MFTGIIEETGTIESMKKAGHAMALTIKCSKILEDVHLGDSIAVN GICLTVTDFTKNQFTVDVMPETVKATSLNDLTKGSKVNLERAMAANGRFGGHFVSGHV DGTAEITRIEEKSNAVYYDLKMDPSLTKTLVLKGSITVDGVSLTIFGLTEDTVTISLI PHTISETIFSEKTIGSKVNIECDMIGKYMYRFLHKANENKTQQTITKAFLSENGF*" /label="ribE CDS" gene complement(2022749..2023396) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /label="ribE gene" CDS complement(2023407..2024492) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /EC_number="1.1.1.193" /EC_number="3.5.4.26" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9068650, 12456892, 17765262, 18986985, 23385458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068650, 12456892, 17765262, 18986985, 23385458; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5-phosphoribosylamino) uracil reductase" /protein_id="NP_390209.1" /db_xref="EnsemblGenomes-Gn:BSU23280" /db_xref="EnsemblGenomes-Tr:CAB14260" /db_xref="GOA:P17618" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR004794" /db_xref="InterPro:IPR011549" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024072" /db_xref="PDB:2B3Z" /db_xref="PDB:2D5N" /db_xref="PDB:3EX8" /db_xref="PDB:4G3M" /db_xref="SubtiList:BG10518" /db_xref="UniProtKB/Swiss-Prot:P17618" /translation="MEEYYMKLALDLAKQGEGQTESNPLVGAVVVKDGQIVGMGAHLK YGEAHAEVHAIHMAGAHAEGADIYVTLEPCSHYGKTPPCAELIINSGIKRVFVAMRDP NPLVAGRGISMMKEAGIEVREGILADQAERLNEKFLHFMRTGLPYVTLKAAASLDGKI ATSTGDSKWITSEAARQDAQQYRKTHQSILVGVGTVKADNPSLTCRLPNVTKQPVRVI LDTVLSIPEDAKVICDQIAPTWIFTTARADEEKKKRLSAFGVNIFTLETERIQIPDVL KILAEEGIMSVYVEGGSAVHGSFVKEGCFQEIIFYFAPKLIGGTHAPSLISGEGFQSM KDVPLLQFTDITQIGRDIKLTAKPTKE*" /label="ribD CDS" gene complement(2023407..2024492) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /label="ribD gene" S_feature complement(2024493..2024621) /Source="Nicolas_S_feature" /locus_tag="new_2431344_2431472_c" /HighExp="T0.30H, B60, T1.30H, T2.0H, MG-0.2, T1.0H, S1, T0.0H, LPhT, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S881" misc_RNA complement(2024622..2024766) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /product="flavin riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508, 17693491, 17997835" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508, 17693491, 17997835; Product type n: RNA" /label="fswA RNA" gene complement(2024622..2024766) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /label="fswA gene" promotor_-10 complement(2024783..2024802) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2024793) /Source="Nicolas_upshifts" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2024817..2024824) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2024886..2025230) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390211.1" /db_xref="EnsemblGenomes-Gn:BSU23300" /db_xref="EnsemblGenomes-Tr:CAB14262" /db_xref="SubtiList:BG10516" /db_xref="UniProtKB/Swiss-Prot:P17616" /translation="MGRIKTKITILLVLLLLLAGGYMYINDIELKDVPTAIGQTLSSE EEEYTIQEYKVTKIDGSEYHGVAENGTKIIFNGKKLNQDLSDIKEGDKIKAYFSKSKR IDGLIKVAKVND*" /label="ypuD CDS" gene complement(2024886..2025230) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /label="ypuD gene" downshifts complement(2024901) /Source="Nicolas_upshifts" /id="D1217" /incds=0 /nref=78 /ntot=221 /MaxReadThrough="1.58771" /MaxDrop="5.14851" /score="20.5522057" /energy="-14.7" /TU="NA" /idTUdmin="U1820" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2025262..2025280) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2025275) /Source="Nicolas_upshifts" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2025289..2025294 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2025295..2025301) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2025309..2026231 /Source="Nicolas_S_feature" /locus_tag="new_2432160_2433082" /HighExp="S5, S4, S6, S8, S7, C30, S3, C90, BT, BC" /AntisenseName="sipS" /AntisenseCor="-0.46666993867379197" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S882" upshifts 2025309 /Source="Nicolas_upshifts" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2025310..2025328 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2025316..2025331) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2025319) /Source="Nicolas_upshifts" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2025321..2025387) /Source="Nicolas_S_feature" /locus_tag="new_2432172_2432238_c" /HighExp="Etha, T1.30H, M9-stat, T0.30H, M40t90, T2.30H, MG-0.2, MG 15, HiTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S883" promotor_-35 complement(2025344..2025353) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2025382..2025390) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2025387) /Source="Nicolas_upshifts" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2025404..2025412) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2025465..2026019) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /EC_number="3.4.21.89" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390212.1" /db_xref="EnsemblGenomes-Gn:BSU23310" /db_xref="EnsemblGenomes-Tr:CAB14263" /db_xref="GOA:P28628" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG10515" /db_xref="UniProtKB/Swiss-Prot:P28628" /translation="MKSENVSKKKSILEWAKAIVIAVVLALLIRNFIFAPYVVDGDSM YPTLHNRERVFVNMTVKYIGEFDRGDIVVLNGDDVHYVKRIIGLPGDTVEMKNDQLYI NGKKVDEPYLAANKKRAKQDGFDHLTDDFGPVKVPDNKYFVMGDNRRNSMDSRNGLGL FTKKQIAGTSKFVFYPFNEMRKTN*" /label="sipS CDS" gene complement(2025465..2026019) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /label="sipS gene" downshifts complement(2025475) /Source="Nicolas_upshifts" /id="D1218" /incds=0 /nref=195 /ntot=252 /MaxReadThrough="3.6233" /MaxDrop="7.24702" /score="30.4586783" /energy="-10.9" /TU="U1824" /idTUdmin="U1825" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2026045..2026064) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2026063) /Source="Nicolas_upshifts" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2026065..2026464) /Source="Nicolas_S_feature" /locus_tag="new_2432916_2433315_c" /HighExp="T4.0H, T2.30H, T5.0H, T3.0H, T2.0H, T3.30H, M9-stat, C90, BC, T1.30H" /AntisenseName="ypzC" /AntisenseCor="-0.215992681600812" /AntisenseRegPval="-3.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S884" promotor_-35 complement(2026076..2026082) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2026286..2026522 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390213.1" /db_xref="EnsemblGenomes-Gn:BSU23320" /db_xref="EnsemblGenomes-Tr:CAB14264" /db_xref="SubtiList:BG13765" /db_xref="UniProtKB/Swiss-Prot:O32012" /translation="MFIYCIPLISQSMIPMALDKTINVMKVTGMFAATYFTGDNRTPF FAFIICLKSFKLENMDQPPKNKSNIFPAVEDSLL*" /label="ypzC CDS" gene 2026286..2026522 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /label="ypzC gene" CDS complement(2026465..2026671) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097757.1" /db_xref="EnsemblGenomes-Gn:BSU23328" /db_xref="EnsemblGenomes-Tr:CAX52656" /db_xref="InterPro:IPR018652" /db_xref="UniProtKB/Swiss-Prot:C0H447" /translation="MNNKGCIKCGSTEAGQKEIATTGTGLSKLFDVQHNRFLVVYCKN CGYSEFYNKESSTAGNILDLFFGG*" /label="ypzJ CDS" gene complement(2026465..2026671) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /label="ypzJ gene" misc_feature complement(2026704..2026723) /Source="Nicolas_upshift_promotors" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2026726) /Source="Nicolas_upshifts" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="upshifts" CDS complement(2026780..2027034) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="PSEUDO:CAX52657.1" /translation="MSFLVFVLIFLFVILTRRVCKLLHFFVYYRFIPHRAEPCVLYEQ YPSDVAAGYAFGGVWLSLNVLVMELFRFSRRFTKLRNEPN*" /label="ypuC CDS" gene complement(2026780..2027034) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /pseudo /label="ypuC gene" promotor_-35 2026914..2026923 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2026925..2027314) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15849754, 16850406" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="SubtiList:BG10514" /translation="MSYWIGYRLGPAAIQKAFASRGVLLAVIVLTFFWTVFRGQDRKI ELSFLFFLVIGGELYEEGIRRLFHSLHPVHAPLESHVLYPFPSEQTLTAFVIFGFCAY LFVRHSHKTRLQTVAFFCLLSFYSSSG*" /label="ypuC CDS" gene complement(2026925..2027314) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /pseudo /label="ypuC gene" S_feature 2026937..2028008 /Source="Nicolas_S_feature" /locus_tag="new_2433788_2434859" /HighExp="S6, S8, S7, BT, S5, B36, S4, Pyr, G/S, C30" /AntisenseName="ypuC" /AntisenseCor="0.37168085148262697" /AntisenseRegPval="-9.5" /CDS_PredictionProba="0.69113899999999995" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S885" promotor_-10 2026937..2026956 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2026937 /Source="Nicolas_upshifts" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2027292..2027495) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390215.1" /db_xref="EnsemblGenomes-Gn:BSU23340" /db_xref="EnsemblGenomes-Tr:CAB14266" /db_xref="SubtiList:BG10513" /db_xref="UniProtKB/Swiss-Prot:P35151" /translation="MQVLTGLLEQYGYAVLFIVLMLELLALLGPGEFAGVLVFQEKLN WVLSMLAAGLGSCGSEHVVLDRV*" /label="ypuB CDS" gene complement(2027292..2027495) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /label="ypuB gene" CDS 2027904..2028020 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90572.1" /translation="MYMHFESAQDDPITFARKAAAAFRVVKRIDRYLGFRKL*" /label="hypothetical protein CDS" gene 2027904..2028020 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /pseudo /label="gene" downshifts 2027971 /Source="Nicolas_upshifts" /id="D1219" /incds=0 /nref=3 /ntot=18 /MaxReadThrough="-0.179729999999999" /MaxDrop="3.76747" /score="-7.5033349" /energy="-9.1" /TU="NA" /idTUdmin="U1826" /TUdmin=198 /isTUend="FALSE" /label="downshifts" promotor_-35 2028097..2028106 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2028119..2028138 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2028119 /Source="Nicolas_upshifts" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="upshifts" CDS 2028161..2028373 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative germination protein" /protein_id="NP_390216.1" /db_xref="EnsemblGenomes-Gn:BSU23350" /db_xref="EnsemblGenomes-Tr:CAB14267" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13766" /db_xref="UniProtKB/Swiss-Prot:O32013" /translation="MIDYPININNVSGNSVINVGGAFMIRPLTLSKSVFGSGGLNTGI VFENNFVSKAKMINHQFTDQNVTKTF*" /label="ypzD CDS" gene 2028161..2028373 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /label="ypzD gene" downshifts 2028367 /Source="Nicolas_upshifts" /id="D1220" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="4.9048" /MaxDrop="3.6863" /score="3.56038753" /energy="-6.9" /TU="U1827" /idTUdmin="U1827" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" downshifts complement(2028509) /Source="Nicolas_upshifts" /id="D1221" /incds=0 /nref=254 /ntot=263 /MaxReadThrough="2.52018" /MaxDrop="8.47213" /score="34.3429406" /energy="-12.4" /TU="NA" /idTUdmin="U1828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2028509..2028940) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8639516, 9063446, 9748346, 25184565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8639516, 9063446, 9748346, 25184565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-prolyl isomerase" /protein_id="NP_390217.1" /db_xref="EnsemblGenomes-Gn:BSU23360" /db_xref="EnsemblGenomes-Tr:CAB14268" /db_xref="GOA:P35137" /db_xref="InterPro:IPR002130" /db_xref="InterPro:IPR020892" /db_xref="InterPro:IPR024936" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG10512" /db_xref="UniProtKB/Swiss-Prot:P35137" /translation="MKTGYFLLEDGNKIEFELYPEAAPGTVANFEKLANEGFYDGLTF HRVIPGFVSQGGCPHGTGTGGPGYTIKCETEGNPHTHEAGALSMAHAGKDTGGSQFFI VHEPQPHLNGVHTVFGKVTSGLEFAKNMSNGDVMKEVRVEG*" /label="ppiB CDS" gene complement(2028509..2028940) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /label="ppiB gene" S_feature complement(2028941..2029027) /Source="Nicolas_S_feature" /locus_tag="new_2435792_2435878_c" /HighExp="dia5, dia15, dia0, Lbexp, LBGtran, C90, Lbtran, HPh, G180, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S886" promotor_-10 complement(2029010..2029029) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2029027) /Source="Nicolas_upshifts" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2029043..2029048) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2029077..2029086 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2029096..2029193 /Source="Nicolas_S_feature" /locus_tag="new_2435947_2436044" /HighExp="Heat, Etha, Salt, dia0, HiTm, T0.30H, B60, Lbexp, T1.0H, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S887" upshifts 2029096 /Source="Nicolas_upshifts" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2029099..2029114 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2029194..2030066 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17434969, 18179421, 24706874; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390218.1" /db_xref="EnsemblGenomes-Gn:BSU23370" /db_xref="EnsemblGenomes-Tr:CAB14269" /db_xref="InterPro:IPR009343" /db_xref="SubtiList:BG10511" /db_xref="UniProtKB/Swiss-Prot:P31847" /translation="MKKIWIGMLAAAVLLLMVPKVSLADAAVGDVIVTLGADLSESDK QKVLDEMNVPDNATTVTVTNKEEHEYLGKYISNAQIGSRAISSSSITIAKKGSGLNVE THNISGITDEMYLNALMTAGVKDAKVYVTAPFEVSGTAALTGLIKAYEVSSDEAISED VKQVANQELVTTSELGDKIGNENAAALIAKIKEEFAKNGVPDNKADIEKQVDDAASDL NVTLTDSQKNQLVSLFNKMKNADIDWGQVSDQLDKAKDKITKFIESDEGKNFIQKVID FFVSIWNAIVSIFK*" /label="ypuA CDS" gene 2029194..2030066 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /label="ypuA gene" downshifts 2029973 /Source="Nicolas_upshifts" /id="D1222" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="5.9994" /MaxDrop="4.15288" /score="27.7277161" /energy="-12.7" /TU="U1829" /idTUdmin="U1829" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 2030039 /Source="Nicolas_upshifts" /id="D1223" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="1.98749" /MaxDrop="5.95835" /score="27.7277161" /energy="-12.7" /TU="NA" /idTUdmin="U1829" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2030096..2031415) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /EC_number="4.1.1.20" /experiment="publication(s) with functional evidences, PMID:9044297, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9044297, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-2,6-diaminopimelate decarboxylase" /protein_id="NP_390219.1" /db_xref="EnsemblGenomes-Gn:BSU23380" /db_xref="EnsemblGenomes-Tr:CAB14270" /db_xref="GOA:P23630" /db_xref="InterPro:IPR000183" /db_xref="InterPro:IPR002986" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR022643" /db_xref="InterPro:IPR022644" /db_xref="InterPro:IPR022653" /db_xref="InterPro:IPR022657" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10510" /db_xref="UniProtKB/Swiss-Prot:P23630" /translation="MFLHGTSRQNQHGHLEIGGVDALYLAEKYGTPLYVYDVALIRER AKSFKQAFISAGLKAQVAYASKAFSSVAMIQLAEEEGLSLDVVSGGELYTAVAAGFPA ERIHFHGNNKSREELRMALEHRIGCIVVDNFYEIALLEDLCKETGHSIDVLLRITPGV EAHTHDYITTGQEDSKFGFDLHNGQTERAIEQVLQSEHIQLLGVHCHIGSQIFDTAGF VLAAEKIFKKLDEWRDSYSFVSKVLNLGGGFGIRYTEDDEPLHATEYVEKIIEAVKEN ASRYGFDIPEIWIEPGRSLVGDAGTTLYTVGSQKEVPGVRQYVAVDGGMNDNIRPALY QAKYEAAAANRIGEAHDKTVSIAGKCCESGDMLIWDIDLPEVKEGDLLAVFCTGAYGY SMANNYNRIPRPAVVFVENGEAHLVVKRETYEDIVKLDLPFKTGVKQ*" /label="lysA CDS" gene complement(2030096..2031415) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /label="lysA gene" downshifts complement(2030116) /Source="Nicolas_upshifts" /id="D1224" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.99445" /MaxDrop="5.13504" /score="28.6775009" /energy="-12.7" /TU="NA" /idTUdmin="U1830" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2031416..2031480) /Source="Nicolas_S_feature" /locus_tag="new_2438267_2438331_c" /HighExp="C90, HiOs, BMM, GM 120, GM 25, MG-0.2, GM 15, GM-0.2, MG t5, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S888" promotor_-10 complement(2031476..2031495) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2031480) /Source="Nicolas_upshifts" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2031510..2031517) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2031521..2032139) /gene="spoVAF" /locus_tag="PG10_5'_ext_BSU_23390" /old_locus_tag="BSU_23390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AF" /protein_id="NP_390220.2" /db_xref="EnsemblGenomes-Gn:BSU23390" /db_xref="EnsemblGenomes-Tr:CAB14271" /db_xref="GOA:P31845" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10508" /db_xref="UniProtKB/Swiss-Prot:P31845" /modified_by="User" /translation="MTTSSGKIFRYSCFYFISSDLVSLCASA*SAPGQHEIYRFK*RY AYPDHPADIFS*LRNRVSQNGCHSHTDGFIDSNGFNCRCSDRADCD*GRPFFS*GDSV RLTCGDWNLYDA*L*IKLGKQNEPSCPHDTRCFISYKRARHRIYSANYCHGKHQIPSD TVLMAADSL*RKGAVAGSCPHSETWRKSKTQHRSPQKSLKAAYQFI" /label="PG10_5'_ext_BSU_23390" gene complement(2031521..2032139) /gene="PG10_5'_ext_BSU_23390" /locus_tag="PG10_pseudo_BSU_23390" /old_locus_tag="BSU_23390" /modified_by="User" /label="PG10_5'_ext_BSU_23390" SCAR join(2032125,2032132) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs23" N_region 2032126..2032131 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs23" S_feature complement(<2032132..2032148) /Source="Nicolas_S_feature" /locus_tag="new_2445036_2445093_c" /HighExp="S4, S3, S7, S5, S8, S6, T5.0H, BT, LoTm, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.859" /TUlongSig="NA" /TUlongPSig="NA" /label="S889" CDS complement(2032149..2033318) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /EC_number="3.4.16.4" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8021191, 8936302, 9864321, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021191, 8936302, 9864321, 19189487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicilin binding protein)" /protein_id="NP_390229.1" /db_xref="EnsemblGenomes-Gn:BSU23480" /db_xref="EnsemblGenomes-Tr:CAB14280" /db_xref="GOA:P38422" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10295" /db_xref="UniProtKB/Swiss-Prot:P38422" /translation="MKRLLSTLLIGIMLLTFAPSAFAKQDGKRTSELAHEAKSAVLIE RDTGKVLYNKNSNERLAPASMTKIMTMLLIMEALDKGKIKMSDKVRTSEHAASMGGSQ IFLEPGEEMTVKEMLKGIAIASGNDASVAMAEFISGSEEEFVKKMNKKAKELGLKNTS FKNPTGLTEEGHYSSAYDMAIMAKELLKYESITKFTGTYEDYLRENTDKKFWLVNTNR LIKFYPGVDGVKTGYTGEAKYCLTASAKKGNMRAIAVVFGASTPKERNAQVTKMLDFA FSQYETHPLYKRNQTVAKVKVKKGKQKFIELTTSEPISILTKKGEDMNDVKKEIKMKD NISAPIQKGQELGTLVLKKDGEVLAESPVAAKEDMKKAGFITFLKRTMGDWTKFK*" /label="dacF CDS" gene complement(2032149..2033318) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /label="dacF gene" promotor_-10 complement(2033347..2033358) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2033362) /Source="Nicolas_upshifts" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2033372..2033378) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2033464) /Source="Nicolas_upshifts" /id="D1226" /incds=0 /nref=243 /ntot=267 /MaxReadThrough="0.87114" /MaxDrop="7.5376" /score="26.8559416" /energy="-16.7" /TU="NA" /idTUdmin="U1836" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2033473..2034288) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 15530033, 21279421, 21543875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 15530033, 21279421, 21543875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_390230.1" /db_xref="EnsemblGenomes-Gn:BSU23490" /db_xref="EnsemblGenomes-Tr:CAB14281" /db_xref="GOA:P46354" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR011268" /db_xref="InterPro:IPR011270" /db_xref="InterPro:IPR018099" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG11330" /db_xref="UniProtKB/Swiss-Prot:P46354" /translation="MKDRIERAAAFIKQNLPESPKIGLILGSGLGILADEIENPVKLK YEDIPEFPVSTVEGHAGQLVLGTLEGVSVIAMQGRFHFYEGYSMEKVTFPVRVMKALG VEALIVTNAAGGVNTEFRAGDLMIITDHINFMGTNPLIGPNEADFGARFPDMSSAYDK DLSSLAEKIAKDLNIPIQKGVYTAVTGPSYETPAEVRFLRTMGSDAVGMSTVPEVIVA NHAGMRVLGISCISNAAAGILDQPLSHDEVMEVTEKVKAGFLKLVKAIVAQYE*" /label="pupG CDS" gene complement(2033473..2034288) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /label="pupG gene" CDS complement(2034301..2035485) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /EC_number="5.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,5-phosphopentomutase" /protein_id="NP_390231.2" /db_xref="EnsemblGenomes-Gn:BSU23500" /db_xref="EnsemblGenomes-Tr:CAB14282" /db_xref="GOA:P46353" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR010045" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR024052" /db_xref="SubtiList:BG11331" /db_xref="UniProtKB/Swiss-Prot:P46353" /translation="MPAYKYNRVFLIVMDSVGIGEAPDAADFNDEGAHTLGHIAEHMN GLHMPNMAKLGLGLIEDIKGVEKTEHPLAYYGKMQEASNGKDTMTGHWEIMGLYIDKP FKVFPEGFPDELLQELEKRSGRKIIGNKPASGTAILDELGQEHMETGALIVYTSADSV LQIAAHEEVVPLEELYRICETARELTLDPKYMVGRIIARPFVGEPGQFKRTPNRHDYA LKPFDRTVMNELKDCGLDVISIGKISDIYDGEGITSSRRTVSNMDGMDKVIDTLGEDF TGLSFANLVDFDALFGHRRDPEGYGRALEEFDARLPEVFEKMREDDLLIITADHGNDP IHHGTDHTREYVPILAYSKKHKKAQMLPLADTFADIGATIADNFQTNKPKYGKSFLSL LQ*" /label="deoB CDS" gene complement(2034301..2035485) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /label="deoB gene" promotor_-10 complement(2035534..2035553) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2035552) /Source="Nicolas_upshifts" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2035554..2035645) /Source="Nicolas_S_feature" /locus_tag="new_2448499_2448590_c" /HighExp="S3, S4, M0t90, G180, S7, S8, Glucon, G135, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigEF, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S890" promotor_-35 complement(2035569..2035576) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2035646..2036536) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_390232.2" /db_xref="EnsemblGenomes-Gn:BSU23510" /db_xref="EnsemblGenomes-Tr:CAB14283" /db_xref="GOA:P46352" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011932" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG11332" /db_xref="UniProtKB/Swiss-Prot:P46352" /translation="MKDQIKDFIHYVMVERGLSQNTIVSYERDLKSYSLYLTETLHVT DWNHVTRIHIIQYLKHLKDSGKSGKTSARHLASIRSFHQFLLREKVTDKDPSVHIETQ KTERALPKVLALNEVERLLDTPKLTSPFGYRDKAMLELLYATGIRVSEMIELKTADVH LSMGFIRCFGKGRKERIVPIGEAAASAIEEYMTKARGKLLKNNVSDALFLNHHGKQIS RQGFWKNLKKIALEAGIKKELTPHTLRHSFATHLLENGADLRAVQEMLGHADISTTQI YTHVTKTRLKDVYKQFHPRA*" /label="ripX CDS" gene complement(2035646..2036536) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /label="ripX gene" CDS complement(2036544..2036771) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097760.1" /db_xref="EnsemblGenomes-Gn:BSU23519" /db_xref="EnsemblGenomes-Tr:CAX52660" /db_xref="GOA:C0H451" /db_xref="InterPro:IPR025321" /db_xref="UniProtKB/Swiss-Prot:C0H451" /translation="MGRFLKTAVDALKVFILFTGFTALFYYAMIWVNQEYENYHRYDK PEGSAVKVVEMDQDEKGGWFDRLIFFYQNGE*" /label="yqzK CDS" gene complement(2036544..2036771) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /label="yqzK gene" promotor_-10 complement(2036674..2036693) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2036685) /Source="Nicolas_upshifts" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2036707..2036714) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2036764) /Source="Nicolas_upshifts" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2036773..2036791) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2036801..2036819) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2036807..2036813) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2036814) /Source="Nicolas_upshifts" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2036836..2036841) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2036896) /Source="Nicolas_upshifts" /id="D1227" /incds=0 /nref=159 /ntot=251 /MaxReadThrough="4.06128" /MaxDrop="5.73495" /score="5.40881961" /energy="-8.1" /TU="U1840" /idTUdmin="U1841" /TUdmin=506 /isTUend="FALSE" /label="downshifts" CDS complement(2036896..2037345) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for iron transport andmetabolism" /protein_id="NP_390233.2" /db_xref="EnsemblGenomes-Gn:BSU23520" /db_xref="EnsemblGenomes-Tr:CAB14284" /db_xref="GOA:P54574" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11766" /db_xref="UniProtKB/Swiss-Prot:P54574" /translation="MENRIDRIKKQLHSSSYKLTPQREATVRVLLENEEDHLSAEDVY LLVKEKSPEIGLATVYRTLELLTELKVVDKINFGDGVSRYDLRKEGAAHFHHHLVCME CGAVDEIEEDLLEDVEEIIERDWKFKIKDHRLTFHGICHRCNGKETE*" /label="fur CDS" gene complement(2036896..2037345) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /label="fur gene" promotor_-10 complement(2037369..2037388) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-10" upshifts complement(2037379) /Source="Nicolas_upshifts" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="upshifts" S_feature complement(2037381..2037457) /Source="Nicolas_S_feature" /locus_tag="new_2450326_2450402_c" /HighExp="S3, S4, S5, BT, LoTm, M9-stat, T5.0H, T3.30H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S891" promotor_-35 complement(2037404..2037408) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-35" CDS complement(2037458..2038102) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17376078, 17824930, 20382772, 23859254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17376078, 17824930, 20382772, 23859254; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="autolysin component for dissolution of the septal cell wall (stage II sporulation)" /protein_id="NP_390234.1" /db_xref="EnsemblGenomes-Gn:BSU23530" /db_xref="EnsemblGenomes-Tr:CAB14285" /db_xref="GOA:P37873" /db_xref="InterPro:IPR002798" /db_xref="InterPro:IPR014196" /db_xref="SubtiList:BG10768" /db_xref="UniProtKB/Swiss-Prot:P37873" /translation="MRKISYKDMFLRHVKDHLSLYIFVSVLFFMGVIFGAIIVNSMTI SQKEDLYYYLSQFFGQLSDGKQASSADMFGQSIFHNAKYLGLMWILGISVIGMPIIFI MIFLKGIVVGFTVGFLVNQMGVSGFFLSFVSVLPQNVLLIPAYLIMGTCAIAFSLKLI RQLFVKRSLHDAPIQWFGRYAFVLLVILFLALISSLFEAYLSPVLMEKLTSRLF*" /label="spoIIM CDS" gene complement(2037458..2038102) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /label="spoIIM gene" promotor_-10 complement(2038133..2038151) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-10" upshifts complement(2038150) /Source="Nicolas_upshifts" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="upshifts" promotor_-35 complement(2038166..2038171) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-35" CDS complement(2038203..2038418) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390235.1" /db_xref="EnsemblGenomes-Gn:BSU23540" /db_xref="EnsemblGenomes-Tr:CAB14286" /db_xref="SubtiList:BG11765" /db_xref="UniProtKB/Swiss-Prot:P54573" /translation="MAKSQAKKKRGHRLRNGGRDVLLSRGSTPSFSTHGRMTKSKKEI LNKRKHKNPYDHTAVDDKDFFVPQKAA*" /label="yqkK CDS" gene complement(2038203..2038418) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /label="yqkK gene" downshifts complement(2038283) /Source="Nicolas_upshifts" /id="D1228" /incds=1 /nref=17 /ntot=130 /MaxReadThrough="0.857610000000001" /MaxDrop="3.7055" /score="1.77181315" /energy="-9.8" /TU="NA" /idTUdmin="U1842" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2038518..2039837) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 23136871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catabolic NAD-dependent malic enzyme (conversionof malate into pyruvate)" /protein_id="NP_390236.1" /db_xref="EnsemblGenomes-Gn:BSU23550" /db_xref="EnsemblGenomes-Tr:CAB14287" /db_xref="GOA:P54572" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11764" /db_xref="UniProtKB/Swiss-Prot:P54572" /translation="MIAKHMIRTLMIETPSVPGNLGRVATAIGLLGGDIGEVETVKVG PNYTMRNITVQVENEEQLQEVIAAVQALGEGIRLHTVSDEVLSAHEGGKIQMKSKMPI RSLAELGRVYTPGVADVCRLIEKEPEKASIYTTISNSVAIVTDGTAILGLGNIGSVAG MPVMEGKAALFDQLAGISGIPILLDTSDPEEIIKTVKHISPGFSGILLEDIGSPHCFE IEDRLKEELNIPVMHDDQHGTAVVTLAAAISACRSAGVDLKEAKVGQIGLGAAGVAIC RMFMAYGVNAVYGTDKSESAMNRLEQYGGQAVSSIEELMETCDIVIATTGVPGLIKPA FVRSGQVILALSNPKPEIEPEAALQAGAAYAADGRSVNNVLGFPGIFRGALNAKSTEI NHDMLVAAAEAIAACTKQGDVVPQPLDSKVHHAVAAAVEHAALTAVK*" /label="mleA CDS" gene complement(2038518..2039837) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /label="mleA gene" downshifts complement(2038525) /Source="Nicolas_upshifts" /id="D1229" /incds=0 /nref=29 /ntot=84 /MaxReadThrough="3.50516" /MaxDrop="5.65279" /score="42.1653011" /energy="-15.2" /TU="U1842,U1843" /idTUdmin="U1842" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" CDS complement(2039855..2041261) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10903309, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10903309, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="malate-H+/Na+-lactate antiporter" /protein_id="NP_390237.1" /db_xref="EnsemblGenomes-Gn:BSU23560" /db_xref="EnsemblGenomes-Tr:CAB14288" /db_xref="GOA:P54571" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG11763" /db_xref="UniProtKB/Swiss-Prot:P54571" /translation="MKDVRLPTLFEIIIVLGVFLALVLSFTVFLDLPIQLALFVSWFI AMLLGIRLGYSYKDLQNAIVHGISNGLEAVLILVSVGALIGTWIAGGVVPTLIYYGLE FIHPSIFLLATLIICSIMSVATGTSWGTVGTAGIAMIAIGEGLGIPLPLVAGAILSGA YFGDKLSPLSDSTVLASSLSKVDVLAHVRAMLYLSIPAYVITAILFTVVGFMYGGKNI DLDKVEFLKSSLQNTFDIHIWMLIPAVLVIVLLAMKKPSMPVIVIGALLGAIWAVVFQ GMDIAHAIATAYNGFSIKTDVEFLNGLLNRGGIVGMLDSLVVIIFGLGFGGLLEKLGV LKVIVSTFEKKLTSAGNVTLSTLIVAFLANIFGCAMYVSLILTPKIMEDSYDRLHLDR RVLSRNSEVGGTLTSGMVPWSDNGIYMAGILGVSTFSYLPFMWLSFVAIGLAIIYGYT GKFIWYTKNNTVKAEKLG*" /label="mleN CDS" gene complement(2039855..2041261) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /label="mleN gene" promotor_-10 complement(2041309..2041328) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2041318) /Source="Nicolas_upshifts" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2041320..2041401) /Source="Nicolas_S_feature" /locus_tag="new_2454265_2454346_c" /HighExp="S0, dia0, dia5, Lbexp, G150, Oxctl, G135, Mt0, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S892" promotor_-35 complement(2041343..2041350) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2041402..2042829) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /EC_number="4.3.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-aspartase (aspartate ammonia lyase)" /protein_id="NP_390238.2" /db_xref="EnsemblGenomes-Gn:BSU23570" /db_xref="EnsemblGenomes-Tr:CAB14289" /db_xref="GOA:P26899" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004708" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10301" /db_xref="UniProtKB/Swiss-Prot:P26899" /translation="MLNGQKEYRVEKDFLGEKQIEADVYYGIQTLRASENFPITGYKI HEEMINALAIVKKAAALANMDVKRLYEGIGQAIVQAADEILEGKWHDQFIVDPIQGGA GTSMNMNANEVIGNRALEIMGHKKGDYIHLSPNTHVNMSQSTNDVFPTAIHISTLKLL EKLLKTMEDMHSVFKQKAQEFDSVIKMGRTHLQDAVPIRLGQEFEAYSRVLERDIKRI KQSRQHLYEVNMGATAVGTGLNADPEYIKQVVKHLADISGLPLVGADHLVDATQNTDA YTEVSASLKVCMMNMSKIANDLRLMASGPRAGLAEISLPARQPGSSIMPGKVNPVMAE LINQIAFQVIGNDNTICLASEAGQLELNVMEPVLVFNLLQSISIMNNGFRSFTDNCLK GIEANEKRMKQYVEKSAGVITAVNPHLGYEAAARIAREAIMTGQSVRDLCLQHDVLTE EELDIILNPYEMTKPGIAGKELLEK*" /label="ansB CDS" gene complement(2041402..2042829) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /label="ansB gene" CDS complement(2042874..2043863) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /EC_number="3.5.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029, 11914346, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029, 11914346, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported L-asparaginase" /protein_id="NP_390239.1" /db_xref="EnsemblGenomes-Gn:BSU23580" /db_xref="EnsemblGenomes-Tr:CAB14290" /db_xref="GOA:P26900" /db_xref="InterPro:IPR006033" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG10300" /db_xref="UniProtKB/Swiss-Prot:P26900" /translation="MKKLLMLTTGGTIASVEGENGLAPGVKADELLSYVSKLDNDYTM ETQSLMNIDSTNMQPEYWVEIAEAVKENYDAYDGFVITHGTDTMAYTSAALSYMLQHA KKPIVITGSQIPITFQKTDAKKNITDAIRFACEGVGGVYVVFDGRVIQGTRAIKLRTK SYDAFESINYPYIAFINEDGIEYNKQVTEPENDTFTVDTSLCTDVCLLKLHPGLKPEM FDALKSMYKGIVIESYGSGGVPFEGRDILSKVNELIESGIVVVITTQCLEEGEDMSIY EVGRRVNQDLIIRSRNMNTEAIVPKLMWALGQSSDLPVVKRIMETPIADDVVL*" /label="ansA CDS" gene complement(2042874..2043863) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /label="ansA gene" S_feature complement(2043864..2043943) /Source="Nicolas_S_feature" /locus_tag="new_2456809_2456888_c" /HighExp="dia0, Lbexp, G150, Oxctl, dia5, LBGexp, Paraq, C30, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S893" promotor_-10 complement(2043925..2043944) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2043943) /Source="Nicolas_upshifts" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2043945..2044265) /Source="Nicolas_S_feature" /locus_tag="new_2456890_2457210_c" /HighExp="LBGstat, S5, G135, S8, S6, LBGtran, G180, G150, LoTm, LBGexp" /AntisenseName="ansR" /AntisenseCor="0.23077291929287899" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S894" promotor_-35 complement(2043959..2043966) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2043984..2043991 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2044004..2044023 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2044006 /Source="Nicolas_upshifts" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="upshifts" CDS 2044045..2044395 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of ansAB (Xre family)" /protein_id="NP_390240.1" /db_xref="EnsemblGenomes-Gn:BSU23590" /db_xref="EnsemblGenomes-Tr:CAB14291" /db_xref="GOA:Q07683" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG10299" /db_xref="UniProtKB/Swiss-Prot:Q07683" /translation="MNLDRLTELRKKKNWSLQYTADLLGIAKSTYAGYESGYRRPSLE ALAMLADLFDTTCDELLGREKQKQTAPQAIELATWSSLDFTISVDGQPLSEDEIIQLI TFIRTKRKVQEELS*" /label="ansR CDS" gene 2044045..2044395 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /label="ansR gene" S_feature complement(2044267..2044403) /Source="Nicolas_S_feature" /locus_tag="new_2457212_2457348_c" /HighExp="LBGstat, S8, S6, S7, S5, ferm, nit, LBGtran, BT, LPhT" /AntisenseName="ansR" /AntisenseCor="-0.22421651781702501" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S895" downshifts complement(2044310) /Source="Nicolas_upshifts" /id="D1230" /incds=1 /nref=4 /ntot=116 /MaxReadThrough="3.90926" /MaxDrop="4.76642" /score="10.2434094" /energy="-23.6" /TU="U1847" /idTUdmin="U1845" /TUdmin=1451 /isTUend="FALSE" /label="downshifts" CDS complement(2044404..2045567) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleotide binding protein" /protein_id="NP_390241.2" /db_xref="EnsemblGenomes-Gn:BSU23600" /db_xref="EnsemblGenomes-Tr:CAB14292" /db_xref="GOA:P38423" /db_xref="InterPro:IPR005287" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG11073" /db_xref="UniProtKB/Swiss-Prot:P38423" /translation="MKKIYADLHIHIGRTFTGRAVKITGAKTLTLDRILVEASEHKGI ELLGIIDCHSPEVILELEEGISSGKYRELDGGGIRYRSTTLLLGSELEIYDEACSGPI HVLVFMPTLADMKQFSNWLSARLKNIHLSSQRIYETGLNLQKKVQDMGGLFIPAHIFT PHKSLYGKGVKSSLTEVFDPSMIDAVELGLSCDTDMASHVSQLNPYPFLTNSDAHSLG KIGREYNELYVQSADFTEFALALKGQDDRKIIANYGLDPLLGKYYQTACEACGEPAVS GETACANCGKARFTKGVSDRLRELSDQLEVRVPRPRYVHQIPLQFVPGVGPKTLDKLK KAFGTEMAVLHEAAEEDLARVVPPKTAALIVKARSGKLELKAGGGGTYGKIKP*" /label="yqxK CDS" gene complement(2044404..2045567) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /label="yqxK gene" CDS complement(2045564..2046121) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /EC_number="3.1.7.1" /EC_number="3.6.1.13" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10542272, 17693564, 21638333, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl pyrophosphate and dimethylallyl pyrophosphate diphosphatase (moonlighting ADP-ribose pyrophosphatase)" /protein_id="NP_390242.1" /db_xref="EnsemblGenomes-Gn:BSU23610" /db_xref="EnsemblGenomes-Tr:CAB14293" /db_xref="GOA:P54570" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11762" /db_xref="UniProtKB/Swiss-Prot:P54570" /translation="MKSLEEKTIAKEQIFSGKVIDLYVEDVELPNGKASKREIVKHPG AVAVLAVTDEGKIIMVKQFRKPLERTIVEIPAGKLEKGEEPEYTALRELEEETGYTAK KLTKITAFYTSPGFADEIVHVFLAEELSVLEEKRELDEDEFVEVMEVTLEDALKLVES REVYDAKTAYAIQYLQLKEALQAQK*" /label="nudF CDS" gene complement(2045564..2046121) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /label="nudF gene" promotor_no_box complement(2046051..2046151) /Source="Nicolas_upshift_promotors" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2046091) /Source="Nicolas_upshifts" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2046135..2046140 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2046156..2046174 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2046158..2046172) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-10" upshifts 2046162 /Source="Nicolas_upshifts" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="upshifts" S_feature 2046169..2046343 /Source="Nicolas_S_feature" /locus_tag="new_2459114_2459288" /HighExp="S4, S5, S3, S7, S6, LoTm, BT, T5.0H, G/S, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99962399999999996" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S896" promotor_-35 complement(2046174..2046177) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-35" upshifts complement(2046177) /Source="Nicolas_upshifts" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="upshifts" CDS 2046196..2046318 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /function="15.1: Cell division" /experiment="publication(s) with functional evidences, PMID:18284588, 23237472, 25848052, 27752253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18284588, 23237472, 25848052, 27752253; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="YP_009513976.1" /db_xref="EnsemblGenomes-Gn:BSU23616" /db_xref="EnsemblGenomes-Tr:CCQ48600" /db_xref="GOA:L8EBJ9" /db_xref="InterPro:IPR025177" /db_xref="PDB:2MRW" /db_xref="PDB:4U39" /db_xref="UniProtKB/TrEMBL:L8EBJ9" /translation="MKVHRMPKGVVLVGKAWEIRAKLKEYGRTFQYVKDWISKP*" /label="mciZ CDS" gene 2046196..2046318 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /label="mciZ gene" promotor_-35 2046319..2046326 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2046340..2046359 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2046345 /Source="Nicolas_upshifts" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="upshifts" CDS 2046381..2047301 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /EC_number="1.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9643546, 15317791, 16242712, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent aldo-keto reductase (acts on 4-hydroxy-2,3-trans-nonenal)" /protein_id="NP_390243.1" /db_xref="EnsemblGenomes-Gn:BSU23620" /db_xref="EnsemblGenomes-Tr:CAB14294" /db_xref="GOA:P54569" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11761" /db_xref="UniProtKB/Swiss-Prot:P54569" /translation="MRKRKLGTSDLDISEVGLGCMSLGTEKNKALSILDEAIELGINY LDTADLYDRGRNEEIVGDAIQNRRHDIILATKAGNRWDDGSEGWYWDPSKAYIKEAVK KSLTRLKTDYIDLYQLHGGTIEDNIDETIEAFEELKQEGVIRYYGISSIRPNVIKEYV KKSNIVSIMMQFSLFDRRPEEWLPLLEEHQISVVARGPVAKGLLTEKPLDQASESMKQ NGYLSYSFEELTNARKAMEEVAPDLSMTEKSLQYLLAQPAVASVITGASKIEQLRENI QAANARRLTEEEIKALQSHTKQDIYKAHRS*" /label="yqkF CDS" gene 2046381..2047301 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /label="yqkF gene" downshifts 2047290 /Source="Nicolas_upshifts" /id="D1231" /incds=0 /nref=186 /ntot=248 /MaxReadThrough="1.49159" /MaxDrop="5.81013" /score="18.6018806" /energy="-14.8" /TU="NA" /idTUdmin="U1846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2047333..2047557) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390244.1" /db_xref="EnsemblGenomes-Gn:BSU23630" /db_xref="EnsemblGenomes-Tr:CAB14295" /db_xref="InterPro:IPR024980" /db_xref="SubtiList:BG11760" /db_xref="UniProtKB/Swiss-Prot:P54568" /translation="MKKQKSIDKHQLKDGLQSDIKAKLMEMKSQLKEEDEKRQKREKA EQIRKKKEIEKNKSFEELLNESQMDWHQYK*" /label="yqkE CDS" gene complement(2047333..2047557) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /label="yqkE gene" downshifts complement(2047390) /Source="Nicolas_upshifts" /id="D1232" /incds=0 /nref=19 /ntot=195 /MaxReadThrough="0.59953" /MaxDrop="5.9087" /score="15.8160537" /energy="-13" /TU="NA" /idTUdmin="U1849" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2047580..2047599) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2047587) /Source="Nicolas_upshifts" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2047614..2047621) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2047636..2047643 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2047658..2047677 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2047665 /Source="Nicolas_upshifts" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="upshifts" CDS 2047719..2048636 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390245.1" /db_xref="EnsemblGenomes-Gn:BSU23640" /db_xref="EnsemblGenomes-Tr:CAB14296" /db_xref="GOA:P54567" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11759" /db_xref="UniProtKB/Swiss-Prot:P54567" /translation="MKKILLAIGALVTAVIAIGIVFSHMILFIKKKTDEDIIKRETDN GHDVFESFEQMEKTAFVIPSAYGYDIKGYHVAPHDTPNTIIICHGVTMNVLNSLKYMH LFLDLGWNVLIYDHRRHGQSGGKTTSYGFYEKDDLNKVVSLLKNKTNHRGLIGIHGES MGAVTALLYAGAHCSDGADFYIADCPFACFDEQLAYRLRAEYRLPSWPLLPIADFFLK LRGGYRAREVSPLAVIDKIEKPVLFIHSKDDDYIPVSSTERLYEKKRGPKALYIAENG EHAMSYTKNRHTYRKTVQEFLDNMNDSTE*" /label="yqkD CDS" gene 2047719..2048636 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /label="yqkD gene" downshifts 2048611 /Source="Nicolas_upshifts" /id="D1233" /incds=0 /nref=27 /ntot=171 /MaxReadThrough="2.02201" /MaxDrop="3.99393" /score="14.106821" /energy="-11.8" /TU="NA" /idTUdmin="U1850" /TUdmin=594 /isTUend="FALSE" /label="downshifts" CDS complement(2048676..2048915) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390246.1" /db_xref="EnsemblGenomes-Gn:BSU23650" /db_xref="EnsemblGenomes-Tr:CAB14297" /db_xref="InterPro:IPR020157" /db_xref="SubtiList:BG11758" /db_xref="UniProtKB/Swiss-Prot:P54566" /translation="MEQKLKAMKNTAQNKTWVSFLNQNHPYTLLHWSIGGAESIKKDV WLLQDEMTFETQEFTTIDLAIEWIRENMDGITDVL*" /label="yqkC CDS" gene complement(2048676..2048915) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /label="yqkC gene" downshifts complement(2048687) /Source="Nicolas_upshifts" /id="D1234" /incds=0 /nref=215 /ntot=269 /MaxReadThrough="3.31829" /MaxDrop="6.35785" /score="16.3526162" /energy="-11.2" /TU="NA" /idTUdmin="U1851" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2048928..2049251) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390247.1" /db_xref="EnsemblGenomes-Gn:BSU23660" /db_xref="EnsemblGenomes-Tr:CAB14298" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11757" /db_xref="UniProtKB/Swiss-Prot:P54565" /translation="MNIHVTDAAKQALQQAFDANPGKKAQLRYDAEGCGCAVSGVPTI WLAEELTGQCEQLETNGIPLYIQSSQKVFFDDQMTIDYNEKAKTLALKSPAEMLSPRM SILVK*" /label="yqkB CDS" gene complement(2048928..2049251) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /label="yqkB gene" promotor_-10 complement(2048994..2049013) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2048995) /Source="Nicolas_upshifts" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2049027..2049034) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2049248..2050279) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390248.1" /db_xref="EnsemblGenomes-Gn:BSU23670" /db_xref="EnsemblGenomes-Tr:CAB14299" /db_xref="GOA:P54564" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR007344" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11756" /db_xref="UniProtKB/Swiss-Prot:P54564" /translation="MIEFLQHKEATIAREILAVQIPAYIKETEIIGFDGIPALQEKVK DIQASHERFAGYRKNGKLIGVISYEKNMHYLTICRLVVHPDGFRKGIGRALLQFVIDH NEDAEKIEVVTAENNTPAVSLYTQAGFQKAETVKAAQGLLLSVFHLYPKRKVEIILYN EKWAECFDEEKERLKLVFGPEIIAIHHIGSTSIPNMAAKPIIDMLIEVRSIEAVSQFD EQMKANGYTPKGENGIAGRRYFQKGGNKRTHHVHMYEQGNPAIERHLLFRDYLRAHPN IAKEYAVLKKQLAAQHPDSINQYIQGKDEWIKTAEENAKRWKKGRNNANGSIVCYNSE NDENGGFTL*" /label="yqkA CDS" gene complement(2049248..2050279) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /label="yqkA gene" promotor_-10 complement(2049275..2049294) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2049282) /Source="Nicolas_upshifts" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2049305..2049312) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2050272..2050616) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradation enzyme (oxygenase)" /protein_id="NP_390249.1" /db_xref="EnsemblGenomes-Gn:BSU23680" /db_xref="EnsemblGenomes-Tr:CAB14300" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:2GO8" /db_xref="SubtiList:BG11755" /db_xref="UniProtKB/Swiss-Prot:P54563" /translation="MMDFLSKTPEPPYYAVIFSSVKSENDTGYGETAERMVSLAADQP GFLGVESVREADGRGITVSYWDSMDAINHWRHHTEHQAAKEKGRSVWYESYAVRVAKV DRQRLFQENTND*" /label="yqjZ CDS" gene complement(2050272..2050616) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /label="yqjZ gene" CDS complement(2050626..2051096) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390250.1" /db_xref="EnsemblGenomes-Gn:BSU23690" /db_xref="EnsemblGenomes-Tr:CAB14301" /db_xref="GOA:P54562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017255" /db_xref="PDB:1MK4" /db_xref="SubtiList:BG11754" /db_xref="UniProtKB/Swiss-Prot:P54562" /translation="MDIRTITSSDYEMVTSVLNEWWGGRQLKEKLPRLFFEHFQDTSF ITSEHNSMTGFLIGFQSQSDPETAYIHFSGVHPDFRKMQIGKQLYDVFIETVKQRGCT RVKCVTSPVNKVSIAYHTKLGFDIEKGTKTVNGISVFANYDGPGQDRVLFVKNI*" /label="yqjY CDS" gene complement(2050626..2051096) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /label="yqjY gene" S_feature complement(2051097..2051173) /Source="Nicolas_S_feature" /locus_tag="new_2464042_2464118_c" /HighExp="SMM, T-4.40H, MG 150, M9-tran, GM 90, T-3.40H, GM-0.2, M9-exp, GM 120, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigEF" /TUlongPSig="0.776" /label="S897" downshifts 2051097 /Source="Nicolas_upshifts" /id="D1235" /incds=0 /nref=8 /ntot=121 /MaxReadThrough="0.87367" /MaxDrop="3.61005" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2051148..2051167) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2051173) /Source="Nicolas_upshifts" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2051175..2051281) /Source="Nicolas_S_feature" /locus_tag="new_2464120_2464226_c" /HighExp="M40t90, S4, M40t45, S6, H2O2, S5, S3, S8, S7, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.776" /TUlongSig="NA" /TUlongPSig="NA" /label="S898" promotor_-35 complement(2051182..2051189) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2051282..2051620) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390251.1" /db_xref="EnsemblGenomes-Gn:BSU23700" /db_xref="EnsemblGenomes-Tr:CAB14302" /db_xref="GOA:P54561" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG11753" /db_xref="UniProtKB/Swiss-Prot:P54561" /translation="MNDHLKRGNLLWEGSRMFLPEHKQSLLERKRLKQKLQKPILDPD KLEEMNQTLCAAMEFAQDITVSCFQDGEIVCCTGKICRYEEFEKAVWIKGDEDQLYKL KLDQVLDIVL*" /label="yqjX CDS" gene complement(2051282..2051620) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /label="yqjX gene" CDS complement(2051617..2052855) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /EC_number="2.7.7.7" /function="16.5: Explore" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Y family DNA polymerase V bypassing lesions during replication" /protein_id="NP_390252.1" /db_xref="EnsemblGenomes-Gn:BSU23710" /db_xref="EnsemblGenomes-Tr:CAB14303" /db_xref="GOA:P54560" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11752" /db_xref="UniProtKB/Swiss-Prot:P54560" /translation="MMKEKVIFLVDMQSFYASVEKAENPHLKNRPVIVSGDPEKRGGV VLAACPLAKQKGVVNASRLWEAQEKCPEAVVLRPRMQRYIDVSLQITAILEEYTDLVE PYSIDEQFMDITGSQKLFGTPMEIAKSIQGRIMREIGVYARVGIGPNKALAKIACDNF AKKNKNGIFTLTKENMKTEMWPLPVGSMFGVGSRMKHHLNRMGISTIGGLAAFPLDLL KKKWGINGHVLWMTANGIDYSPVSTSSLDGQKAIGHGMTLPRDYEHFDKEIKVVLLEL SEEVCRRSRNAGVMGQTVSVSCRGADFDWPTGFNRQVKLAEPTNSTQDVYEAVRRLFL TFWDGKPVRRLGVNLSQLSSDDIWQLNLFQDYAKKMSLGYVMDGIKNRFGDTAIIRAA SLTAAGQAFERAAKIGGHYK*" /label="polYB CDS" gene complement(2051617..2052855) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /label="polYB gene" misc_feature 2051779..2051780 /Source="Nicolas_upshift_promotors" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2051790 /Source="Nicolas_upshifts" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2051845 /Source="Nicolas_upshifts" /id="D1236" /incds=1 /nref=2 /ntot=2 /MaxReadThrough="-0.14995" /MaxDrop="4.86715" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2052880..2052898) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-10" upshifts complement(2052889) /Source="Nicolas_upshifts" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="upshifts" promotor_-35 complement(2052915..2052920) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-35" promotor_-35 2052960..2052963 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2052978..2052997 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2052987 /Source="Nicolas_upshifts" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="upshifts" CDS 2053021..2053227 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390253.1" /db_xref="EnsemblGenomes-Gn:BSU23720" /db_xref="EnsemblGenomes-Tr:CAB14304" /db_xref="InterPro:IPR025546" /db_xref="SubtiList:BG13774" /db_xref="UniProtKB/Swiss-Prot:O32014" /translation="MEKFVEKMLGQALRQYGRNVAIDPLSPYEKQSLKAALQERRNEE PDEDLHAHIEDIIYDYVTNQGLFS*" /label="yqzH CDS" gene 2053021..2053227 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /label="yqzH gene" promotor_-35 2053710..2053713 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2053728..2053747 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2053744 /Source="Nicolas_upshifts" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="upshifts" CDS 2053776..2055008 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390254.2" /db_xref="EnsemblGenomes-Gn:BSU23730" /db_xref="EnsemblGenomes-Tr:CAB14305" /db_xref="GOA:P54559" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11751" /db_xref="UniProtKB/Swiss-Prot:P54559" /translation="MKKWKDIHPISWTIIIGTIFGRMATSMSIPFLAIYLTAVQGASA SYAGLVIAASSSVGILASFYGGYISDKFGRKNMMLVSIFGWMLVFAGFAAASNLWVFF VVNALNGLCKSLFEPASKALLSDMTEEKTRLLVFNLRYAAINIGVVFGPVLGLYFGSS QSTTPFLVPAVIYGLYGIVLALQFKKHPSLSAPAQSRNMSVREAFMVTQKDYLFTIAL VGITLCTFGYSQFSSTFPQYMAQNPLIGNGTKLYGLMLTLNAIVVLATQFPIVHFAKR FSPLCSLMLGNVMVSISMAIFTVSHGVPSIVMIVITFTIGEVLLFSMMDLYVDQIAKP GLKGTYFGAIGFSQLGNVIGPWVGGICIDLFGAGRPIYIFSVLSGITLLGLPFLAFAY RQMKMETTKHRSRLEKPL*" /label="yqjV CDS" gene 2053776..2055008 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /label="yqjV gene" CDS 2054855..2055217 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390255.2" /db_xref="EnsemblGenomes-Gn:BSU23740" /db_xref="EnsemblGenomes-Tr:CAB14306" /db_xref="GOA:P54558" /db_xref="SubtiList:BG11750" /db_xref="UniProtKB/Swiss-Prot:P54558" /translation="MYRPVWRWPADLYFFCPERHYPARPAIFSVRLSANENGDHKTPF PSGKAALNKKRKRMNLSRKHEVKNMNIGDVMFQLFVFIIFAAVVFAAVTGFKYAKNRK AQLDRIEKKLNSLSEDHD*" /label="yqjU CDS" gene 2054855..2055217 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /label="yqjU gene" S_feature complement(2055034..2055213) /Source="Nicolas_S_feature" /locus_tag="new_2467979_2468158_c" /HighExp="Sw, BC, C90, C30, M0t90, BI, Lbtran, Lbstat, M40t45, G135" /AntisenseName="yqjU" /AntisenseCor="-0.38632421151235602" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S899" downshifts complement(2055067) /Source="Nicolas_upshifts" /id="D1237" /incds=0 /nref=59 /ntot=226 /MaxReadThrough="1.66997" /MaxDrop="4.81479" /score="21.7095422" /energy="-11.4" /TU="NA" /idTUdmin="U1858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2055214..2055600) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390256.1" /db_xref="EnsemblGenomes-Gn:BSU23750" /db_xref="EnsemblGenomes-Tr:CAB14307" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11749" /db_xref="UniProtKB/Swiss-Prot:P54557" /translation="MHHIELYVSDLEASRRFWGWFLKELGYKEYQKWSSGISWKKDRF YLVIVQAKEPFLEPEYHRCRVGLNHLAFHAESKLQVDQMTEKLTAKGYRVLYRDRHPF AGGDGHYAVFCEDPDRIKVELVAPSC*" /label="yqjT CDS" gene complement(2055214..2055600) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /label="yqjT gene" CDS complement(2055604..2056563) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328157, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328157, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase" /protein_id="NP_390257.2" /db_xref="EnsemblGenomes-Gn:BSU23760" /db_xref="EnsemblGenomes-Tr:CAB14308" /db_xref="GOA:P54556" /db_xref="InterPro:IPR004566" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11748" /db_xref="UniProtKB/Swiss-Prot:P54556" /translation="MKNKELNLHTLYTQHNRESWSGFGGHLSIAVSEEEAKAVEGLND YLSVEEVETIYIPLVRLLHLHVKSAAERNKHVNVFLKHPHSAKIPFIIGIAGSVAVGK STTARILQKLLSRLPDRPKVSLITTDGFLFPTAELKKKNMMSRKGFPESYDVKALLEF LNDLKSGKDSVKAPVYSHLTYDREEGVFEVVEQADIVIIEGINVLQSPTLEDDRENPR IFVSDFFDFSIYVDAEESRIFTWYLERFRLLRETAFQNPDSYFHKFKDLSDQEADEMA ASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV*" /label="coaA CDS" gene complement(2055604..2056563) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /label="coaA gene" S_feature complement(2056564..2056634) /Source="Nicolas_S_feature" /locus_tag="new_2469509_2469579_c" /HighExp="LBGtran, dia15, Diami, C90, H2O2, M0t45, G135, Lbtran, HiTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S900" CDS complement(2056635..2057981) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /EC_number="4.3.1.18" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-serine ammonia-lyase" /protein_id="NP_390258.2" /db_xref="EnsemblGenomes-Gn:BSU23770" /db_xref="EnsemblGenomes-Tr:CAB14309" /db_xref="GOA:P54555" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011780" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG11747" /db_xref="UniProtKB/Swiss-Prot:P54555" /translation="MSVHSEVLHALLKDPFIQKLIDAEPVFWANSGKKEGPLPRADEW ATEIAEAEKRMQRFAPYIAEVFPETKGAKGIIESPLFEVQHMKGKLEAAYQQPFPGRW LLKCDHELPISGSIKARGGIYEVLKYAENLALQEGMLQETDDYRILQEERFTGFFSRY SIAVGSTGNLGLSIGIIGAALGFRVTVHMSADAKQWKKDLLRQKGVTVMEYETDYSEA VNEGRRQAEQDPFCYFIDDEHSRQLFLGYAVAASRLKTQLDCMNIKPSLETPLFVYLP CGVGGGPGGVAFGLKLLYGDDVHVFFAEPTHSPCMLLGLYSGLHEKISVQDIGLDNQT AADGLAVGRPSGFVGKLIEPLLSGCYTVEDNTLYTLLHMLAVSEDKYLEPSALAGMFG PVQLFSTEEGRRYAQKYKMEHAVHVVWGTGGSMVPKDEMAAYNRIGADLLKKRNEK*" /label="dsdA CDS" gene complement(2056635..2057981) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /label="dsdA gene" S_feature complement(2057982..2058056) /Source="Nicolas_S_feature" /locus_tag="new_2470927_2471001_c" /HighExp="C90, LBGtran, Diami, dia15, H2O2, dia5, G150, MG 15, GM-0.2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S901" CDS complement(2058057..2058836) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metabolite dehydrogenase, NAD-binding" /protein_id="NP_390259.1" /db_xref="EnsemblGenomes-Gn:BSU23780" /db_xref="EnsemblGenomes-Tr:CAB14310" /db_xref="GOA:P54554" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11746" /db_xref="UniProtKB/Swiss-Prot:P54554" /translation="MKHIAGKRIWITGASGGLGERIAYLCAAEGAHVLLSARREDRLI EIKRKITEEWSGQCEIFPLDVGRLEDIARVRDQIGSIDVLINNAGFGIFETVLDSTLD DMKAMFDVNVFGLIACTKAVLPQMLEQKKGHIINIASQAGKIATPKSSLYSATKHAVL GYSNALRMELSGTGIYVTTVNPGPIQTDFFSIADKGGDYAKNVGRWMLDPDDVAAQIT AAIFTKKREINLPRLMNAGTKLYQLFPALVEKLAGRALMKK*" /label="yqjQ CDS" gene complement(2058057..2058836) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /label="yqjQ gene" CDS complement(2058842..2059801) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390260.1" /db_xref="EnsemblGenomes-Gn:BSU23790" /db_xref="EnsemblGenomes-Tr:CAB14311" /db_xref="GOA:P54553" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11745" /db_xref="UniProtKB/Swiss-Prot:P54553" /translation="MTTEDVIAIRVPTPFAVGDVIVYLVKGDALTLIDAGPNTKEAAR ALQEQLAAVNVKLSDIEQVVLTHHHADHAGLLDVFSDEIEVIGHTFNEPYISQNQAFM DWQKRFFQKLLPELGVPFDTGKAEKLIRSAYAFSCTRSLTKSIREGMGIDGLEGWSVL EMPGHAESHIVLFHEKSGRMLGGDLLLANSSSNPILEAPKAGDVRSKPLVDYQRSLRR LSQLDPTIVFPGHGEPITSVQALIEKRFDKQRNRTEDVRRMLDEKPMTAFQVCQQLFP AVYEKELFLTMSETAGHLDVLEAEEAITSYWEGNTVYFKTMKR*" /label="yqjP CDS" gene complement(2058842..2059801) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /label="yqjP gene" promotor_-10 complement(2059823..2059842) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2059842) /Source="Nicolas_upshifts" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2059857..2059864) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2059898..2059905 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2059919..2060205 /Source="Nicolas_S_feature" /locus_tag="new_2472864_2473150" /HighExp="Diami, C90, BC, Paraq, G180, GM 15, Oxctl, S7, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S902" upshifts 2059919 /Source="Nicolas_upshifts" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2059921..2059940 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2059935..2060180 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /product="proline T-box riboswitch" /experiment="publication(s) with functional evidences, PMID:21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21233158" /label="pswI RNA" gene 2059935..2060180 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /label="pswI gene" CDS 2060206..2061042 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21233158, 28752945, 28824574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21233158, 28752945, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase (NADP-dependent, weak activity)" /protein_id="NP_390261.1" /db_xref="EnsemblGenomes-Gn:BSU23800" /db_xref="EnsemblGenomes-Tr:CAB14312" /db_xref="GOA:P54552" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11744" /db_xref="UniProtKB/Swiss-Prot:P54552" /translation="MKKIGFVGAGSMAEAMINGILQSGITKPEHIYITNRSNDERLIE LKETYSVRPCRDKNEFFTHTDIIILAFKPKDAAESIDSIRPYIKDQLVISVLAGLTIE TIQHYFGRKLAVIRVMPNTSAAIRKSATGFSVSTEASKNDIIAAKALLETIGDATLVE ERHLDAVTAIAGSGPAYVYRYIEAMEKAAQKVGLDKETAKALILQTMAGATDMLLQSG KQPEKLRKEITSPGGTTEAGLRALQDSRFEEAIIHCIEETAKRSAEIKEQFAGAALER HS*" /label="proI CDS" gene 2060206..2061042 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /label="proI gene" downshifts 2061040 /Source="Nicolas_upshifts" /id="D1238" /incds=0 /nref=29 /ntot=190 /MaxReadThrough="0.55696" /MaxDrop="3.78131" /score="36.2472665" /energy="-12" /TU="NA" /idTUdmin="U1859" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2061083..2062726) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase" /protein_id="NP_390262.2" /db_xref="EnsemblGenomes-Gn:BSU23810" /db_xref="EnsemblGenomes-Tr:CAB14313" /db_xref="GOA:P54551" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG11743" /db_xref="UniProtKB/Swiss-Prot:P54551" /translation="MNWQTKDELLALLTSLVQYESITGSKGEVALAEYLYFILKDKPY FQKHPDDVTLHPMDDGRSFLTALVKKKNVKKTVLLLSHFDVVDIEDYGEFKHMACKPA ELLSSFLEKKELLPERVRRDAESGDWLFGRGTMDMKAGLCIQLSMLERAMNGHFEGNL LLITVPDEEVNSRGMIEAVPALKEMEKKHDITLTACLNAEPMFEKFPGDQQQYFYTGS IGKVLAGFFCKGIETHVGEPFSGLNANLMVSEINRLLELNADYCEKVDGEVTPPPVNL MQKDLKEAYSVQTPHTAVTLFNVLSMKRSASELHQMLLKTAEQAAEEIMSNVRKKTQD FQQFEPFQPIERDVTVLTFDELVSRAKKRAGISETERALNYAFANRGELGDRDFSTKI VSELASLCKEDAPLIVLFYSPPLYPAVSSKDDQLIRNTADQIKHYAAERYGIALREVQ YFPGLSDLSYLQLEKQEVDAYTSNMPLFNRGYSLPSGKNQALYVPVLNVGPAGKDPHK WTERLYMPYSFEVLPDLLSFTISALLKQSESAGQLLREK*" /label="yqjN CDS" gene complement(2061083..2062726) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /label="yqjN gene" downshifts complement(2061095) /Source="Nicolas_upshifts" /id="D1239" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="2.2598" /MaxDrop="2.55609" /score="14.9380989" /energy="-12" /TU="NA" /idTUdmin="U1861" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2062744..2062750 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2062757 /Source="Nicolas_upshifts" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2062764..2062775 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(2062782..2062801) /Source="Nicolas_upshift_promotors" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2062787) /Source="Nicolas_upshifts" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2062833..2062840 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2062854..2062873 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2062856 /Source="Nicolas_upshifts" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 2062898..2063914 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /EC_number="1.6.99.1" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12660247, 15249051, 15890652, 20011599, 20461254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12660247, 15249051, 15890652, 20011599, 20461254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent flavin oxidoreductase (acting oncinnamaldehyde-related compounds)" /protein_id="NP_390263.1" /db_xref="EnsemblGenomes-Gn:BSU23820" /db_xref="EnsemblGenomes-Tr:CAB14314" /db_xref="GOA:P54550" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023663" /db_xref="PDB:1Z41" /db_xref="PDB:1Z42" /db_xref="PDB:1Z44" /db_xref="PDB:1Z48" /db_xref="SubtiList:BG11742" /db_xref="UniProtKB/Swiss-Prot:P54550" /translation="MARKLFTPITIKDMTLKNRIVMSPMCMYSSHEKDGKLTPFHMAH YISRAIGQVGLIIVEASAVNPQGRITDQDLGIWSDEHIEGFAKLTEQVKEQGSKIGIQ LAHAGRKAELEGDIFAPSAIAFDEQSATPVEMSAEKVKETVQEFKQAAARAKEAGFDV IEIHAAHGYLIHEFLSPLSNHRTDEYGGSPENRYRFLREIIDEVKQVWDGPLFVRVSA SDYTDKGLDIADHIGFAKWMKEQGVDLIDCSSGALVHADINVFPGYQVSFAEKIREQA DMATGAVGMITDGSMAEEILQNGRADLIFIGRELLRDPFFARTAAKQLNTEIPAPVQY ERGW*" /label="yqjM CDS" gene 2062898..2063914 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /label="yqjM gene" downshifts 2063901 /Source="Nicolas_upshifts" /id="D1240" /incds=0 /nref=42 /ntot=157 /MaxReadThrough="2.79686" /MaxDrop="5.04803" /score="39.119339" /energy="-12.8" /TU="U1862" /idTUdmin="U1862" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 2063963..2063972 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2063985..2064000 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2063989 /Source="Nicolas_upshifts" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 2064024..2064785 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390264.1" /db_xref="EnsemblGenomes-Gn:BSU23830" /db_xref="EnsemblGenomes-Tr:CAB14315" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11741" /db_xref="UniProtKB/Swiss-Prot:P54549" /translation="MKSAWMEKTYTIDGCAFHTQHRKGSSGVTIVFEAGYGTSSETWK PLMADIDDEFGIFTYDRAGIGKSGQSRAKRTADQQVKELESLLKAADVKPPYLAVSHS YGAVITGLWACKNKHDIIGMVLLDPALGDCASFTFIPEEMHKSHTRKMMLEGTHAEFS KSLQELKKRQVHLGNMPLLVLSSGERTEKFAAEQEWQNLHSSILSLSNQSGWIQAKNS SHNIHHDEPHIVHLAIYDVWCAACQQAAPLYQAVN*" /label="yqjL CDS" gene 2064024..2064785 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /label="yqjL gene" downshifts 2064693 /Source="Nicolas_upshifts" /id="D1241" /incds=1 /nref=21 /ntot=204 /MaxReadThrough="3.34804" /MaxDrop="3.21955" /score="0.451826768" /energy="-11.2" /TU="U1863" /idTUdmin="U1862" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 2064781 /Source="Nicolas_upshifts" /id="D1242" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="1.34151" /MaxDrop="3.85711" /score="0.451826768" /energy="-11.2" /TU="NA" /idTUdmin="U1863" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2064813..2065013) /Source="Nicolas_S_feature" /locus_tag="new_2477758_2477958_c" /HighExp="B60, S5, Etha, S4, B36, BMM, Heat, S3, S2, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.21631400000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S903" CDS complement(2064829..2064954) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33* pseudogene" /translation="CTETGDRNYITTKNKRTNPDRLELKKYSPRLKKYTLHRETK*" /label="rpmGCc CDS" gene complement(2064829..2064954) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /pseudo /label="rpmGCc gene" downshifts complement(2064856) /Source="Nicolas_upshifts" /id="D1243" /incds=0 /nref=187 /ntot=264 /MaxReadThrough="3.91531" /MaxDrop="7.65732" /score="5.23287853" /energy="-8.8" /TU="U1864" /idTUdmin="U1865" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2064947..2064979) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 19648245, 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33C pseudogene" /db_xref="PSEUDO:CCQ48601.1" /translation="MRVNVTLALH*" /label="rpmGCn CDS" gene complement(2064947..2064979) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /pseudo /label="rpmGCn gene" promotor_-10 complement(2065007..2065026) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2065013) /Source="Nicolas_upshifts" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2065039..2065046) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2065061..2065984) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /EC_number="3.1.26.11" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 12941704, 16336119, 17005971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12941704, 16336119, 17005971; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease Z" /protein_id="NP_390265.1" /db_xref="EnsemblGenomes-Gn:BSU23840" /db_xref="EnsemblGenomes-Tr:CAB14316" /db_xref="GOA:P54548" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR013471" /db_xref="InterPro:IPR036866" /db_xref="PDB:1Y44" /db_xref="PDB:2FK6" /db_xref="PDB:4GCW" /db_xref="SubtiList:BG11740" /db_xref="UniProtKB/Swiss-Prot:P54548" /translation="MELLFLGTGAGIPAKARNVTSVALKLLEERRSVWLFDCGEATQH QILHTTIKPRKIEKIFITHMHGDHVYGLPGLLGSRSFQGGEDELTVYGPKGIKAFIET SLAVTKTHLTYPLAIQEIEEGIVFEDDQFIVTAVSVIHGVEAFGYRVQEKDVPGSLKA DVLKEMNIPPGPVYQKIKKGETVTLEDGRIINGNDFLEPPKKGRSVVFSGDTRVSDKL KELARDCDVLVHEATFAKEDRKLAYDYYHSTTEQAAVTAKEARAKQLILTHISARYQG DASLELQKEAVDVFPNSVAAYDFLEVNVPRG*" /label="rnz CDS" gene complement(2065061..2065984) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /label="rnz gene" promotor_-10 complement(2066010..2066029) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2066023) /Source="Nicolas_upshifts" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2066043..2066048) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2066122..2066129 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2066143..2066162 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2066145..2066210 /Source="Nicolas_S_feature" /locus_tag="new_2479090_2479155" /HighExp="dia5, C90, MG 5, Lbexp, MG t5, MG 45, M9-exp, GM 90, GM 120, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S904" upshifts 2066145 /Source="Nicolas_upshifts" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="upshifts" CDS 2066211..2067680 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /EC_number="1.1.1.49" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1704005, 19779711, 26129872" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1704005, 19779711, 26129872; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate 1-dehydrogenase (NADP-dependent)" /protein_id="NP_390266.2" /db_xref="EnsemblGenomes-Gn:BSU23850" /db_xref="EnsemblGenomes-Tr:CAB14317" /db_xref="GOA:P54547" /db_xref="InterPro:IPR001282" /db_xref="InterPro:IPR019796" /db_xref="InterPro:IPR022674" /db_xref="InterPro:IPR022675" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11739" /db_xref="UniProtKB/Swiss-Prot:P54547" /translation="MKTNQQPKAVIVIFGATGDLAKRKLYPSIHRLYQNGQIGEEFAV VGVGRRPWSNEDLRQTVKTSISSSADKHIDDFTSHFYYHPFDVTNPGSYQELNVLLNQ LEDTYQIPNNRMFYLAMAPEFFGTIAKTLKSEGVTATTGWSRLVIEKPFGHDLPSAQA LNKEIREAFTEDQIYRIDHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSES LGVEDRARYYEKSGALRDMVQNHIMQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPI AKDEVDEYFVRGQYHAGEIDGVPVPAYTDEDNVAPDSNTETFVAGKLLIDNFRWAGVP FYIRTGKRMKEKSTKIVVQFKDIPMNLYYGNENNMNPNLLVIHIQPDEGITLYLNAKK LGGAAHAQPIKLDYCSNCNDELNTPEAYEKLIHDCLLGDATNFAHWDEVALSWSFVDS ISETWAANKTLSPNYESGSMGPKESDDLLVKDGLHWWNI*" /label="zwf CDS" gene 2066211..2067680 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /label="zwf gene" downshifts 2067663 /Source="Nicolas_upshifts" /id="D1244" /incds=0 /nref=206 /ntot=286 /MaxReadThrough="3.46838" /MaxDrop="7.76173" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" terminator 2067688..2067727 /created_by="User" /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" /label="Delta6_zwf-T-gndA_Terminator" Polymorphism join(2067700,2067703) /Source="geneious" /ID="SNP_BsDelta6_2480646_2480647" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="TA -> AT" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TA" /Variant_Nucleotides="AT" /Variant_P_Value=0 /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(2067708,2067709) /Source="geneious" /ID="SNP_BsDelta6_2480654_2480654" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.1e-279" /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(2067720,2067721) /Source="geneious" /ID="SNP_BsDelta6_2480667_2480667" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=116 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.9e-244" /Variant_Raw_Frequency=110 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 2067729 /Source="Nicolas_upshifts" /id="D1245" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="2.5392" /MaxDrop="4.74183" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2067803..2069212) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /EC_number="1.1.1.44" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 15755726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 15755726; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP+-dependent 6-P-gluconate dehydrogenase" /protein_id="NP_390267.2" /db_xref="EnsemblGenomes-Gn:BSU23860" /db_xref="EnsemblGenomes-Tr:CAB14318" /db_xref="GOA:P80859" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11738" /db_xref="UniProtKB/Swiss-Prot:P80859" /translation="MSKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLQ EAKGKNVVGTYSIEEFVQSLETPRKILLMVKAGTATDATIQSLLPHLEKDDILIDGGN TYYKDTQRRNKELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAIS AKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKQVLGLSADELHEVF AEWNKGELDSYLIEITADIFTKKDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVP LPIITESVFARFISAMKEERVKASGLLSGPEVKPVTENKEELIEAVRKALFMSKICSY AQGFAQMKAASEEYNWDLKYGEIAMIFRGGCIIRAAFLQKIKEAYDREPELDNLLLDS YFKNIVESYQGALRQVISLAVAQGVPVPSFSSALAYYDSYRTAVLPANLIQAQRDYFG AHTYERTDKEGIFHTEWMK*" /label="gndA CDS" gene complement(2067803..2069212) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /label="gndA gene" downshifts complement(2067820) /Source="Nicolas_upshifts" /id="D1246" /incds=0 /nref=220 /ntot=361 /MaxReadThrough="1.88983" /MaxDrop="8.82894" /score="24.3727084" /energy="-18" /TU="NA" /idTUdmin="U1867" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" downshifts complement(2067893) /Source="Nicolas_upshifts" /id="D1247" /incds=1 /nref=1 /ntot=36 /MaxReadThrough="8.40595" /MaxDrop="2.3555" /score="24.3727084" /energy="-18" /TU="U1867" /idTUdmin="U1867" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" misc_feature complement(2069276..2069294) /Source="Nicolas_upshift_promotors" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2069278) /Source="Nicolas_upshifts" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2069322..2070566) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /EC_number="2.7.7.7" /function="16.6: Maintain" /function="16.5: Explore" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-damage lesion bypass DNA polymerase" /protein_id="NP_390268.2" /db_xref="EnsemblGenomes-Gn:BSU23870" /db_xref="EnsemblGenomes-Tr:CAB14319" /db_xref="GOA:P54545" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017061" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11737" /db_xref="UniProtKB/Swiss-Prot:P54545" /translation="MPGKSRIIFHIDMNSFYASVEMAYDPALRGKPVAVAGNVKERKG IVVTCSYEARARGVKTTMPVWQAKRHCPELIVLPPNFDRYRNSSRAMFTILREYTDLV EPVSIDEGYMDMTDTPYSSRALETAKEIQSRLQKELLLPSSIGIAPNKFLAKMASDMK KPLGITILRKRQVPDILWPLPVGEMHGVGKKTAEKLKGLGIHTIGELAAADEHSLKRL LGINGPRLKNKANGIHHAPVDPERIYEFKSVGNSSTLSHDSSDEEELLGVFRKLAASV SDRLQRKEVMASKLFIMIRYADWRTITRSTTLRNPIDQKNDILKEAEHLFFKHWNKNP VRLLGITGTDLVEKEQAYKQLDLFSFNEDAKDEPIQQMMEKLNKKYGTKLIRKGATLK KEESKTKGTSFNKDFFQDEKKS*" /label="polYA CDS" gene complement(2069322..2070566) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /label="polYA gene" S_feature complement(2070567..2070841) /Source="Nicolas_S_feature" /locus_tag="new_2483514_2483788_c" /HighExp="M40t90, Sw, M40t45, H2O2, C30, Cold, Etha, C90, Diami, BC" /AntisenseName="yqzJ" /AntisenseCor="0.48883700687558601" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S905" promotor_-35 2070587..2070594 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2070608..2070627 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2070608 /Source="Nicolas_upshifts" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="upshifts" CDS 2070639..2070926 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /experiment="publication(s) with functional evidences, PMID:19779460, 21383133, 22720735, 25313395, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19779460, 21383133, 22720735, 25313395, 25903689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of OxaAB translation" /protein_id="YP_054586.1" /db_xref="EnsemblGenomes-Gn:BSU23880" /db_xref="EnsemblGenomes-Tr:CAE01460" /db_xref="GOA:Q7WY64" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG14191" /db_xref="UniProtKB/Swiss-Prot:Q7WY64" /translation="MTMFVESINDVLFLVDFFTIILPALTAIGIAFLLRECRAGEQWK SKRTDEHQTVFHINRTDFLIIIYHRITTWIRKVFRMNSPVNDEEDAGSLLL*" /label="mifM CDS" gene 2070639..2070926 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /label="mifM gene" promotor_-10 complement(2070823..2070842) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-10" upshifts complement(2070843) /Source="Nicolas_upshifts" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="upshifts" promotor_-35 complement(2070858..2070861) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-35" CDS 2070957..2071784 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_390269.1" /db_xref="EnsemblGenomes-Gn:BSU23890" /db_xref="EnsemblGenomes-Tr:CAB14320" /db_xref="GOA:P54544" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG11736" /db_xref="UniProtKB/Swiss-Prot:P54544" /translation="MLKTYQKLLAMGIFLIVLCSGNAAFAATNQVGGLSNVGFFHDYL IEPFSALLKGVAGLFHGEYGLSIILVTIIVRIVVLPLFVNQFKKQRIFQEKMAVIKPQ VDSIQVKLKKTKDPEKQKELQMEMMKLYQEHNINPLAMGCLPMLIQSPIMIGLYYAIR STPEIASHSFLWFSLGQSDILMSLSAGIMYFVQAYIAQKLSAKYSAVPQNPAAQQSAK LMVFIFPVMMTIFSLNVPAALPLYWFTSGLFLTVQNIVLQMTHHKSKKTAALTESVK* " /label="oxaAB CDS" gene 2070957..2071784 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /label="oxaAB gene" downshifts 2071601 /Source="Nicolas_upshifts" /id="D1248" /incds=1 /nref=4 /ntot=125 /MaxReadThrough="5.05074" /MaxDrop="3.49092" /score="-5.67811369" /energy="-7.6" /TU="U1868" /idTUdmin="U1868" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2071777 /Source="Nicolas_upshifts" /id="D1249" /incds=0 /nref=71 /ntot=229 /MaxReadThrough="1.09826" /MaxDrop="6.56698" /score="-5.67811369" /energy="-7.6" /TU="NA" /idTUdmin="U1868" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2071789..2072709) /Source="Nicolas_S_feature" /locus_tag="new_2484736_2485656_c" /HighExp="LoTm, B36, M0t90, M40t90, Lbstat, M9-stat, T1.30H, B60, LBGtran, BT" /AntisenseName="yqjF" /AntisenseCor="0.18628881890353799" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S906" downshifts complement(2071832) /Source="Nicolas_upshifts" /id="D1250" /incds=0 /nref=170 /ntot=248 /MaxReadThrough="0.24428" /MaxDrop="6.31082" /score="18.1943524" /energy="-12.4" /TU="NA" /idTUdmin="U1871" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2071902..2071908 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2071922..2071940 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2071931 /Source="Nicolas_upshifts" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="upshifts" CDS 2071964..2072692 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390270.3" /db_xref="EnsemblGenomes-Gn:BSU23900" /db_xref="EnsemblGenomes-Tr:CAB14321" /db_xref="InterPro:IPR018644" /db_xref="InterPro:IPR023375" /db_xref="SubtiList:BG11735" /db_xref="UniProtKB/Swiss-Prot:P54543" /translation="MTERFQQKNISVPDGIWIMRQTWNDVLFAHWPVDVSILRALVPS VLELDTYNGQAWISMLPFMLTNLRARYLPVIPGARAFPELNLRTYVTYKGKPGIYFFS LDADHRLAVLGARTFFHLPYFYADMKSEKNGDAIDYVSKRKNDKEAAFHAAYRPISAP FTAEKDSLDYWLTERYRLYTTYRNKLYYEDIHHHPWLLQNAEAEISVNTVTDAHGITL PESDPLLHYAKKQDVLFWPLRKWS*" /label="yqjF CDS" gene 2071964..2072692 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /label="yqjF gene" CDS complement(2072733..2073848) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase or deacylase" /protein_id="NP_390271.2" /db_xref="EnsemblGenomes-Gn:BSU23910" /db_xref="EnsemblGenomes-Tr:CAB14322" /db_xref="GOA:P54542" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR010162" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11734" /db_xref="UniProtKB/Swiss-Prot:P54542" /translation="MVNEKRLLEEFLELVQIDSETKHEAEICKVLKRKFSDLGVDVKE DDTMDITGHGAGNLICTLKGTKQTDTIYFTSHMDTVVPGNGVKPVVENGYVKTDGTTI LGADDKAGLAAMFEAIKVLKEENIEHGTIEFIITVGEESGLIGAKALDRSMITASYGY ALDSDGKVGNIIVAAPTQAKVRAAIFGKTAHAGVEPEKGISAITIASKAISKMPLGRI DEETTANIGRFEGGTQTNIVCDEVHILAEARSLVPEKMEAQVQKMKAAFEEAAADMGG RAEVEIEVMYPGFKYQDGDQVVEIAKKAAAKIGRPSELQTSGGGSDANVIAGHGIPTV NLAVGYEQIHTKNEKMPIEELVKTAEMVVAIIEEAAK*" /label="yqjE CDS" gene complement(2072733..2073848) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /label="yqjE gene" downshifts complement(2072754) /Source="Nicolas_upshifts" /id="D1251" /incds=0 /nref=23 /ntot=203 /MaxReadThrough="3.90071" /MaxDrop="3.95711" /score="11.6635037" /energy="-10.6" /TU="U1871" /idTUdmin="U1871" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" CDS complement(2073866..2075389) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /EC_number="6.4.1.3" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative propionyl-CoA carboxylase beta chain" /protein_id="NP_390272.2" /db_xref="EnsemblGenomes-Gn:BSU23920" /db_xref="EnsemblGenomes-Tr:CAB14323" /db_xref="GOA:P54541" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG11733" /db_xref="UniProtKB/Swiss-Prot:P54541" /translation="MNEHMDHFYTKRKQAEEGGGREKLAQQRQKGKLTARERIIFLLD QDSFIELHPFMESQVLTREQRMLGDGVVTGYGTIDGRSVYVFAQDFTVYGGALGETHA RKICALMDLAAKNKAPIIGLNDSGGARIQEGVLSLDGYGHIFYRNVLYSGVIPQISVI LGPCAGGAVYSPALTDFIFMAEQTGRMFITGPKVIEKVTGEQVDAESLGGAGIHNAVS GNAHFSGHTEKEVLTGVRKLLSYLPLNGRTTEPKPEKEASRPLLNRLVPADTTKPYDV RKVIRELADPQSFFEIQPFFAKNIVIGFARLGEKAIGIVASQPKHLAGSLTIDAADKA ARFIRFCDAFDIPLLTVEDVPGFLPGIQQEHNGIIRHGAKLLFAYAEATVPKVTLIIR KAYGGAYVAMNSKAIGADLVFAWPNAEIAVMGPEGAASILYEKEIKASADPQKTKREK TAEYKKQNAGPYKAAACGMVDDIILPEESRGRLIQAFHMLTHKTEERPKKKHGNIPL* " /label="yqjD CDS" gene complement(2073866..2075389) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /label="yqjD gene" promotor_-10 complement(2074972..2074991) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2074994) /Source="Nicolas_upshifts" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2075006..2075010) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2075382..2075804) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /EC_number="5.1.99.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methylmalonyl-CoA epimerase" /protein_id="NP_390273.2" /db_xref="EnsemblGenomes-Gn:BSU23930" /db_xref="EnsemblGenomes-Tr:CAB14324" /db_xref="GOA:P54540" /db_xref="InterPro:IPR017515" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11732" /db_xref="UniProtKB/Swiss-Prot:P54540" /translation="MNRLDHIGIAVFSIKDARSFYENVLGLAFLHQETVEEQKVNVAF FQAGSVKLELIEPLTADSPVHLFLEKKGQGLHHIAFLCNCLSEQLQALSDQHVQLIDR FPRQGANGKKIAFISPRETNGVLVELCEPKGDQHNEHE*" /label="yqjC CDS" gene complement(2075382..2075804) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /label="yqjC gene" promotor_-35 2075833..2075840 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2075854..2075873 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2075868..2076021 /Source="Nicolas_S_feature" /locus_tag="new_2488815_2488968" /HighExp="LPhT, Etha, dia15, Salt, M9-stat, LBGstat, Heat, BC, T-0.40H, HiOs" /AntisenseName="yqjB" /AntisenseCor="-0.57221813594264503" /AntisenseRegPval="-24.1" /CDS_PredictionProba="0.99822200000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S907" upshifts 2075868 /Source="Nicolas_upshifts" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="upshifts" downshifts 2075978 /Source="Nicolas_upshifts" /id="D1252" /incds=0 /nref=1 /ntot=140 /MaxReadThrough="3.88708" /MaxDrop="3.25163" /score="3.10927996" /energy="-7" /TU="U1872" /idTUdmin="U1872" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" CDS complement(2076006..2076536) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /EC_number="2.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative L,D-transpeptidase" /protein_id="NP_390274.1" /db_xref="EnsemblGenomes-Gn:BSU23940" /db_xref="EnsemblGenomes-Tr:CAB14325" /db_xref="GOA:P54539" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG11731" /db_xref="UniProtKB/Swiss-Prot:P54539" /translation="MRFFLCSIFMMISPIWPLGENPLPGDPYVIVNKRTNELAVILDN KVEGVYSVATGKTDDLTPEGEFSVTVKAENPYYRKKNIEGGSPDNPLGARWIGFDAKG TDGRIYGIHGTNREESVGKFVSNGCIRMHNDEVVHLFQTIPVGTRVLITDDNRSFEEI AIEHKALIKKQDIPIE*" /label="yqjB CDS" gene complement(2076006..2076536) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /label="yqjB gene" S_feature 2076023..2076658 /Source="Nicolas_S_feature" /locus_tag="new_2488970_2489605" /HighExp="LPhT, H2O2, BC, Salt, dia15, M9-stat, Heat, LBGstat, T5.0H, Etha" /AntisenseName="yqjB" /AntisenseCor="-0.31126010332536502" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S908" promotor_-10 complement(2076553..2076564) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2076560) /Source="Nicolas_upshifts" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2076579..2076585) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2076588..2077556) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390275.2" /db_xref="EnsemblGenomes-Gn:BSU23950" /db_xref="EnsemblGenomes-Tr:CAB14326" /db_xref="GOA:P54538" /db_xref="InterPro:IPR010343" /db_xref="InterPro:IPR021062" /db_xref="SubtiList:BG11730" /db_xref="UniProtKB/Swiss-Prot:P54538" /translation="MFKIGYRTIKTALGTALAIYISQLLHLQNFASAGIITILCIQIT QKRSLQASWARFSACCLAIAFSYLFFELIGYHPFVIGALLLIFIPITVLLKINEGIVT SSVIILHLYMSGGITPTFIWNEVQLITVGIGVALLMNLYMPSLDRKLIAYRKKIEDNF AVIFAEIERYLLTGEQDWSGKEIPETHQLITEAKNLAYRDVQNHILRYENLHYHYFKM REKQFEIIERLLPKVTSISITVDQGKMIAEFIHDLREAIHPGNTAYKFLKRLADMRKE FEEMPLPATREEFEARAALFHLLGEMEQYLVIKSYFKGIKAQKSLG*" /label="yqjA CDS" gene complement(2076588..2077556) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /label="yqjA gene" downshifts complement(2076604) /Source="Nicolas_upshifts" /id="D1253" /incds=0 /nref=79 /ntot=223 /MaxReadThrough="2.22356" /MaxDrop="3.94894" /score="1.98299685" /energy="-14.1" /TU="NA" /idTUdmin="U1874" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2077627..2078349) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (ATP-binding protein)" /protein_id="NP_390276.1" /db_xref="EnsemblGenomes-Gn:BSU23960" /db_xref="EnsemblGenomes-Tr:CAB14327" /db_xref="GOA:P54537" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11729" /db_xref="UniProtKB/Swiss-Prot:P54537" /translation="MIKVEKLSKSFGKHEVLKNISTTIAEGEVVAVIGPSGSGKSTFL RCLNLLEKPNGGTITIKDTEITKPKTNTLKVRENIGMVFQHFHLFPHKTVLENIMYAP VNVKKESKQAAQEKAEDLLRKVGLFEKRNDYPNRLSGGQKQRVAIARALAMNPDIMLF DEPTSALDPEMVKEVLQVMKELVETGMTMVIVTHEMGFAKEVADRVLFMDQGMIVEDG NPKEFFMSPKSKRAQDFLEKIL*" /label="artR CDS" gene complement(2077627..2078349) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /label="artR gene" downshifts complement(2077638) /Source="Nicolas_upshifts" /id="D1254" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="4.81216" /MaxDrop="4.0342" /score="0.346345754" /energy="-7" /TU="U1874" /idTUdmin="U1874" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS complement(2078342..2079001) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (permease)" /protein_id="NP_390277.1" /db_xref="EnsemblGenomes-Gn:BSU23970" /db_xref="EnsemblGenomes-Tr:CAB14328" /db_xref="GOA:P54536" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11728" /db_xref="UniProtKB/Swiss-Prot:P54536" /translation="MNLDFSATIPQIPFILEGLAITLKIVVVSAIIGLILGIVLSLCK ISTFRPFIWIADFYTSVFRGTPLVLQLMIVYFGLPQLLGFQIDQFWAAVVALSLNSAA YVSEIIRAGINAIDKGQKEAAVALGVPYGKMMKDLLLPQAFKNISPAIVNELITLTKE SAIVTVIGLGDVMRRAYQAGAATYNYLEPLIIAGLIYYVLVLILTFIGKAVERKLKSN D*" /label="artQ CDS" gene complement(2078342..2079001) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /label="artQ gene" S_feature complement(2079002..2079081) /Source="Nicolas_S_feature" /locus_tag="new_2491949_2492028_c" /HighExp="S1, S2, ferm, MG 15, Fru, Glu, BMM, S3, UNK1, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S909" CDS complement(2079082..2079849) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter binding lipoprotein" /protein_id="NP_390278.1" /db_xref="EnsemblGenomes-Gn:BSU23980" /db_xref="EnsemblGenomes-Tr:CAB14329" /db_xref="GOA:P54535" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11727" /db_xref="UniProtKB/Swiss-Prot:P54535" /translation="MKKWLLLLVAACITFALTACGSSNSGSESGKKKLIMGTSADYKP FEYKEGDNIVGFDVELAKALAKKAGYEIEVQDMDFNSLITALKSKQVDLVLSGMTPTP ERKKQVDFSDVYYTANHMIVSKKDSGIQSLKDLKGKTVGVQLGSIQEEKGKELSPEYG FKTEDRNRISDLVQEIKSDRFDAAIIEDIVAEGYFKSNDDLQGFVIPDAKAEEAGSAI AFRKDSELTDKFNKALKEMEDNGELEKLKKKWFTGEK*" /label="artP CDS" gene complement(2079082..2079849) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /label="artP gene" promotor_-10 complement(2079899..2079918) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2079914) /Source="Nicolas_upshifts" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2079933..2079940) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2080117..2080554) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /experiment="publication(s) with functional evidences, PMID:21749987, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21749987, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin B (de-bacillithiolation)" /protein_id="NP_390279.1" /db_xref="EnsemblGenomes-Gn:BSU23990" /db_xref="EnsemblGenomes-Tr:CAB14330" /db_xref="InterPro:IPR009474" /db_xref="SubtiList:BG11726" /db_xref="UniProtKB/Swiss-Prot:P54534" /translation="MNMDFNLFMNDIVRQARQEITAAGYTELKTAEEVDEALTKKGTT LVMVNSVCGCAGGIARPAAYHSVHYDKRPDQLVTVFAGQDKEATARARDYFEGYPPSS PSFAILKDGKIMKMVERHEIEGHEPMAVVAKLQEAFEEYCEEV*" /label="brxB CDS" gene complement(2080117..2080554) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /label="brxB gene" downshifts complement(2080126) /Source="Nicolas_upshifts" /id="D1255" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="3.9242" /MaxDrop="7.06654" /score="21.489397" /energy="-11.8" /TU="U1875" /idTUdmin="U1875" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2080578..2080597) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-10" upshifts complement(2080599) /Source="Nicolas_upshifts" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="upshifts" promotor_-35 complement(2080612..2080619) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-35" promotor_-35 2080652..2080658 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2080671 /Source="Nicolas_upshifts" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2080673..2080691 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2080715..2081608 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /EC_number="2.7.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7961792, 8098708, 10220166, 17114254, 17535816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipid kinase BmrU" /protein_id="NP_390280.2" /db_xref="EnsemblGenomes-Gn:BSU24000" /db_xref="EnsemblGenomes-Tr:CAB14331" /db_xref="GOA:P39074" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG10302" /db_xref="UniProtKB/Swiss-Prot:P39074" /translation="MSHRKALLIHNGNAGNKNIEKALGAVVPVLSHHLDEVIIKQTKK KDDAYHFCRSIDDSVDTVFILGGDGTIHQCINAISALERKPAVGILPGGTCNDFSRVL GIPQNLAKAAEALMAGKKTSVDVCQMNDRYFLNFWGIGLIAETSNQINETEKALLGKI SYFTSALRTVSSAASFPMTLKIDGEEIKEEAVMLLVMNGQYIGTNRIPLPDASIEDGL LDVLICRNTNLTALRELMSMEQGSIDRFTGELSYVQASRIEIETDTAKKADMDGEVYT HTPAVIQVLPQHIDMLVPANE*" /label="bmrU CDS" gene 2080715..2081608 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /label="bmrU gene" promotor_-35 2081641..2081648 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2081664..2081683 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2081672 /Source="Nicolas_upshifts" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" CDS 2081709..2082878 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10200972, 10961951, 11321573, 15849754, 16850406, 25756668" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10961951, 11321573, 15849754, 16850406, 25756668; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_390281.2" /db_xref="EnsemblGenomes-Gn:BSU24010" /db_xref="EnsemblGenomes-Tr:CAB14332" /db_xref="GOA:P33449" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10303" /db_xref="UniProtKB/Swiss-Prot:P33449" /translation="MEKKNITLTILLTNLFIAFLGIGLVIPVTPTIMNELHLSGTAVG YMVACFAITQLIVSPIAGRWVDRFGRKIMIVIGLLFFSVSEFLFGIGKTVEMLFISRM LGGISAAFIMPGVTAFIADITTIKTRPKALGYMSAAISTGFIIGPGIGGFLAEVHSRL PFFFAAAFALLAAILSILTLREPERNPENQEIKGQKTGFKRIFAPMYFIAFLIILISS FGLASFESLFALFVDHKFGFTASDIAIMITGGAIVGAITQVVLFDRFTRWFGEIHLIR YSLILSTSLVFLLTTVHSYVAILLVTVTVFVGFDLMRPAVTTYLSKIAGNEQGFAGGM NSMFTSIGNVFGPIIGGMLFDIDVNYPFYFATVTLAIGIALTIAWKAPAHLKAST*" /label="bmr CDS" gene 2081709..2082878 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /label="bmr gene" downshifts 2082861 /Source="Nicolas_upshifts" /id="D1256" /incds=0 /nref=6 /ntot=31 /MaxReadThrough="4.82186" /MaxDrop="5.02667" /score="-1.94257488" /energy="-18" /TU="U1876,U1877" /idTUdmin="U1876" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" CDS 2082951..2083787 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11201751, 11839496, 12682015, 14985361, 18658145, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11201751, 11839496, 12682015, 14985361, 18658145, 21690368; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family)" /protein_id="NP_390282.2" /db_xref="EnsemblGenomes-Gn:BSU24020" /db_xref="EnsemblGenomes-Tr:CAB14333" /db_xref="GOA:P39075" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="PDB:1BOW" /db_xref="PDB:1EXI" /db_xref="PDB:1EXJ" /db_xref="PDB:1R8E" /db_xref="PDB:2BOW" /db_xref="PDB:3D6Y" /db_xref="PDB:3D6Z" /db_xref="PDB:3D70" /db_xref="PDB:3D71" /db_xref="PDB:3IAO" /db_xref="PDB:3Q1M" /db_xref="PDB:3Q2Y" /db_xref="PDB:3Q3D" /db_xref="PDB:3Q5P" /db_xref="PDB:3Q5R" /db_xref="PDB:3Q5S" /db_xref="SubtiList:BG10304" /db_xref="UniProtKB/Swiss-Prot:P39075" /translation="MKESYYSIGEVSKLANVSIKALRYYDKIDLFKPAYVDPDTSYRY YTDSQLIHLDLIKSLKYIGTPLEEMKKAQDLEMEELFAFYTEQERQIREKLDFLSALE QTISLVKKRMKRQMEYPALGEVFVLDEEEIRIIQTEAEGIGPENVLNASYSKLKKFIE SADGFTNNSYGATFSFQPYTSIDEMTYRHIFTPVLTNKQISSITPDMEITTIPKGRYA CIAYNFSPEHYFLNLQKLIKYIADRQLTVVSDVYELIIPIHYSPKKQEEYRVEMKIRI AE*" /label="bmrR CDS" gene 2082951..2083787 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /label="bmrR gene" downshifts 2083785 /Source="Nicolas_upshifts" /id="D1257" /incds=0 /nref=5 /ntot=156 /MaxReadThrough="4.1979" /MaxDrop="4.72542" /score="5.00815505" /energy="-15.7" /TU="NA" /idTUdmin="U1876" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2083849) /Source="Nicolas_upshifts" /id="D1258" /incds=0 /nref=15 /ntot=247 /MaxReadThrough="3.01431" /MaxDrop="6.04069" /score="8.5296919" /energy="-16.8" /TU="U1879" /idTUdmin="U1878" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2083849..2085123) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /EC_number="2.3.1.168" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase)" /protein_id="NP_390283.1" /db_xref="EnsemblGenomes-Gn:BSU24030" /db_xref="EnsemblGenomes-Tr:CAB14334" /db_xref="GOA:P37942" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10305" /db_xref="UniProtKB/Swiss-Prot:P37942" /translation="MAIEQMTMPQLGESVTEGTISKWLVAPGDKVNKYDPIAEVMTDK VNAEVPSSFTGTITELVGEEGQTLQVGEMICKIETEGANPAEQKQEQPAASEAAENPV AKSAGAADQPNKKRYSPAVLRLAGEHGIDLDQVTGTGAGGRITRKDIQRLIETGGVQE QNPEELKTAAPAPKSASKPEPKEETSYPASAAGDKEIPVTGVRKAIASNMKRSKTEIP HAWTMMEVDVTNMVAYRNSIKDSFKKTEGFNLTFFAFFVKAVAQALKEFPQMNSMWAG DKIIQKKDINISIAVATEDSLFVPVIKNADEKTIKGIAKDITGLAKKVRDGKLTADDM QGGTFTVNNTGSFGSVQSMGIINYPQAAILQVESIVKRPVVMDNGMIAVRDMVNLCLS LDHRVLDGLVCGRFLGRVKQILESIDEKTSVY*" /label="bkdB CDS" gene complement(2083849..2085123) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /label="bkdB gene" CDS complement(2085146..2086129) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /EC_number="1.2.4.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390284.1" /db_xref="EnsemblGenomes-Gn:BSU24040" /db_xref="EnsemblGenomes-Tr:CAB14335" /db_xref="GOA:P37941" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10306" /db_xref="UniProtKB/Swiss-Prot:P37941" /translation="MSVMSYIDAINLAMKEEMERDSRVFVLGEDVGRKGGVFKATAGL YEQFGEERVMDTPLAESAIAGVGIGAAMYGMRPIAEMQFADFIMPAVNQIISEAAKIR YRSNNDWSCPIVVRAPYGGGVHGALYHSQSVEAIFANQPGLKIVMPSTPYDAKGLLKA AVRDEDPVLFFEHKRAYRLIKGEVPADDYVLPIGKADVKREGDDITVITYGLCVHFAL QAAERLEKDGISAHVVDLRTVYPLDKEAIIEAASKTGKVLLVTEDTKEGSIMSEVAAI ISEHCLFDLDAPIKRLAGPDIPAMPYAPTMEKYFMVNPDKVEAAMRELAEF*" /label="bkdAB CDS" gene complement(2085146..2086129) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /label="bkdAB gene" CDS complement(2086143..2087135) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /EC_number="1.2.4.4" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390285.1" /db_xref="EnsemblGenomes-Gn:BSU24050" /db_xref="EnsemblGenomes-Tr:CAB14336" /db_xref="GOA:P37940" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR034616" /db_xref="SubtiList:BG10307" /db_xref="UniProtKB/Swiss-Prot:P37940" /translation="MSTNRHQALGLTDQEAVDMYRTMLLARKIDERMWLLNRSGKIPF VISCQGQEAAQVGAAFALDREMDYVLPYYRDMGVVLAFGMTAKDLMMSGFAKAADPNS GGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGIALAGRMEKKDIAAFVTFGEGSSNQG DFHEGANFAAVHKLPVIFMCENNKYAISVPYDKQVACENISDRAIGYGMPGVTVNGND PLEVYQAVKEARERARRGEGPTLIETISYRLTPHSSDDDDSSYRGREEVEEAKKSDPL LTYQAYLKETGLLSDEIEQTMLDEIMAIVNEATDEAENAPYAAPESALDYVYAK*" /label="bkdAA CDS" gene complement(2086143..2087135) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /label="bkdAA gene" CDS complement(2087157..2088581) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /EC_number="1.8.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase)" /protein_id="NP_390286.2" /db_xref="EnsemblGenomes-Gn:BSU24060" /db_xref="EnsemblGenomes-Tr:CAB14337" /db_xref="GOA:P54533" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11725" /db_xref="UniProtKB/Swiss-Prot:P54533" /translation="MATEYDVVILGGGTGGYVAAIRAAQLGLKTAVVEKEKLGGTCLH KGCIPSKALLRSAEVYRTAREADQFGVETAGVSLNFEKVQQRKQAVVDKLAAGVNHLM KKGKIDVYTGYGRILGPSIFSPLPGTISVERGNGEENDMLIPKQVIIATGSRPRMLPG LEVDGKSVLTSDEALQMEELPQSIIIVGGGVIGIEWASMLHDFGVKVTVIEYADRILP TEDLEISKEMESLLKKKGIQFITGAKVLPDTMTKTSDDISIQAEKDGETVTYSAEKML VSIGRQANIEGIGLENTDIVTENGMISVNESCQTKESHIYAIGDVIGGLQLAHVASHE GIIAVEHFAGLNPHPLDPTLVPKCIYSSPEAASVGLTEDEAKANGHNVKIGKFPFMAI GKALVYGESDGFVKIVADRDTDDILGVHMIGPHVTDMISEAGLAKVLDATPWEVGQTI HPHPTLSEAIGEAALAADGKAIHF*" /label="lpdV CDS" gene complement(2087157..2088581) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /label="lpdV gene" CDS complement(2088602..2089693) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /EC_number="2.7.2.-" /EC_number="2.7.2.7" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain fatty-acid kinase" /protein_id="NP_390287.2" /db_xref="EnsemblGenomes-Gn:BSU24070" /db_xref="EnsemblGenomes-Tr:CAB14338" /db_xref="GOA:P54532" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR011245" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG11724" /db_xref="UniProtKB/Swiss-Prot:P54532" /translation="MKVLHDEKRILTINPGSTSTKIGVFHNERSIFEKTLRHNIEELQ RFDRIIDQYEFRKNHILETLHEQGINISKFDAVCARGGLLRPIEGGTYVVNDEMIEDL KSGYAGQHASNLGGIIAREIADGLNIPSYIVDPVVVDEMSVLAKVSGMPEIERKSIFH ALNQKAVARKAAASLGKRYENMKMIITHMGGGITIGVHDRGRVVDVNNGLHGEGPFSP ERAGTVPAGDLVDLCFSGEYTKEEIMKKLVGTGGLLGYLGTNDAVKVEQMIQGGDEKA RFIYDAMAYQVAKEIGAASAALKGEVEAIVLTGGLAYGKSFVSAIRSYIDWISDVLVY PGENELQSLAQGALRVLQGEEQSKQYRIE*" /label="buk CDS" gene complement(2088602..2089693) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /label="buk gene" CDS complement(2089712..2090806) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /EC_number="1.4.1.8" /EC_number="1.4.1.-" /EC_number="1.4.1.9" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid dehydrogenase" /protein_id="NP_390288.1" /db_xref="EnsemblGenomes-Gn:BSU24080" /db_xref="EnsemblGenomes-Tr:CAB14339" /db_xref="GOA:P54531" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR016211" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11723" /db_xref="UniProtKB/Swiss-Prot:P54531" /translation="MELFKYMEKYDYEQLVFCQDEQSGLKAIIAIHDTTLGPALGGTR MWTYENEEAAIEDALRLARGMTYKNAAAGLNLGGGKTVIIGDPRKDKNEEMFRAFGRY IQGLNGRYITAEDVGTTVEDMDIIHDETDYVTGISPAFGSSGNPSPVTAYGVYRGMKA AAKAAFGTDSLEGKTIAVQGVGNVAYNLCRHLHEEGANLIVTDINKQSVQRAVEDFGA RAVDPDDIYSQDCDIYAPCALGATINDDTIKQLKAKVIAGAANNQLKETRHGDQIHEM GIVYAPDYVINAGGVINVADELYGYNAERALKKVEGIYGNIERVLEISQRDGIPAYLA ADRLAEERIERMRRSRSQFLQNGHSVLSRR*" /label="bcd CDS" gene complement(2089712..2090806) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /label="bcd gene" CDS complement(2090818..2091717) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /EC_number="2.3.1.19" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphate BCFA and butyryl coenzyme A transferase" /protein_id="NP_390289.2" /db_xref="EnsemblGenomes-Gn:BSU24090" /db_xref="EnsemblGenomes-Tr:CAB14340" /db_xref="GOA:P54530" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR012147" /db_xref="InterPro:IPR014079" /db_xref="SubtiList:BG11722" /db_xref="UniProtKB/Swiss-Prot:P54530" /translation="MKLKDLIGKASIHKNKTIAVAHAEDEEVIRAVKLAAEHLSARFL LTGDSKKLNELTSSMQGHQVEIVHANTPEESAKLAVRAVHHKTADVLMKGNVPTSVLL KAVLNRQEGLRSASVLSHVAVFDIPDFDRLMFVTDSAMNIAPSLEELRQILQNAVHVA HAVGNNMPKAAALAAVETVNPKMEATVNAAALAQMYKRGQIKGCIVDGPLALDNAVSQ IAAAQKKISGDVAGNADILLVPTIEAGNILYKSLIYFAKASVAAVITGAKAPIALTSR ADSAENKLYSIALAICASEEYTH*" /label="ptb CDS" gene complement(2090818..2091717) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /label="ptb gene" misc_feature complement(2091753..2091772) /Source="Nicolas_upshift_promotors" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2091758) /Source="Nicolas_upshifts" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2091760..2091841) /Source="Nicolas_S_feature" /locus_tag="new_2504707_2504788_c" /HighExp="Cold, LBGtran, G180, Lbexp, G135, G150, LBGexp, Diami, Oxctl, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S910" CDS complement(2091842..2093920) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_390290.1" /db_xref="EnsemblGenomes-Gn:BSU24100" /db_xref="EnsemblGenomes-Tr:CAB14341" /db_xref="GOA:P54529" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11721" /db_xref="UniProtKB/Swiss-Prot:P54529" /translation="MQKVLIVGAGKRGTALLHILIKTAIIDIIAVVDKDPEAPGLKEA EQYGIAVSSDWKPYIQQKPDIVIHTTGDQAVFDELLQRKHEDTIVMPGKMAYIVFQLM EEKQHLIQMLKEQTYKYDRIFNSTHDGMIFIDINEEIILFNHMAEKMVGKKREEVIGR PIKEVIPSTKMPRILKTRVPEYNQKQLLGDHLQIVTTRLPIIDEGGRLLGALCVFKDI TDAVELAEEVTNLKQVRTMLEAIIQSSDEAISVVDENGIGLLINKAYTKMTGLSEKEV IGKPANTDISEGESMHLKVLETRRPVRGVRMKVGPNEKEVIVNVAPVIVDGILKGSVG VIHDVSEIKMLTAELNRARQIIRTLEAKYTFDDIIGKSEQMLVALEQAKLGAKTPATI LLRGESGTGKELFAHAIHNESDRKYNKFIRVNCAALSENLLESELFGYEDGAFSGAKR GGKKGLFEEANNGSIFLDEIGELTQNMQAKLLRVLQEKEIVRVGGTKAIPVNVRVIAA TNVNIEKAMADGTFREDLYYRINRYPISIPPLRQRLEDIEALSVRLIQKINRDYGRNV KGLSQQALRALSAYHWPGNVRELENVLGRAMIFLNPHMEWIEKDHLPVFELEQKENDT DQGTGFDFPDIEGEKLSVAVEKFEAHLIQQTLEKHHFNRTKTAKALGVSIRNLYYKMD KYGLANEGMQ*" /label="bkdR CDS" gene complement(2091842..2093920) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /label="bkdR gene" promotor_-10 complement(2093980..2093999) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2093997) /Source="Nicolas_upshifts" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2094007..2094014 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2094016..2094019) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2094028..2094047 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2094035 /Source="Nicolas_upshifts" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="upshifts" CDS 2094073..2094309 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390291.1" /db_xref="EnsemblGenomes-Gn:BSU24110" /db_xref="EnsemblGenomes-Tr:CAB14342" /db_xref="GOA:O32015" /db_xref="InterPro:IPR020138" /db_xref="SubtiList:BG13772" /db_xref="UniProtKB/Swiss-Prot:O32015" /translation="MSRLLALLILVIPGAISALGIKLMRDTLFGHTIKPFSALWLQGL SGFIFFAIGLYVLAGFILYRDRKRNQVSPRFRKR*" /label="yqzF CDS" gene 2094073..2094309 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /label="yqzF gene" downshifts 2094300 /Source="Nicolas_upshifts" /id="D1259" /incds=0 /nref=64 /ntot=230 /MaxReadThrough="2.80342" /MaxDrop="5.10794" /score="42.7247617" /energy="-11.9" /TU="NA" /idTUdmin="U1880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2094351..2095256) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /EC_number="4.1.3.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12706720, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12706720, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylisocitrate lyase" /protein_id="NP_390292.1" /db_xref="EnsemblGenomes-Gn:BSU24120" /db_xref="EnsemblGenomes-Tr:CAB14343" /db_xref="GOA:P54528" /db_xref="InterPro:IPR012695" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018523" /db_xref="SubtiList:BG11720" /db_xref="UniProtKB/Swiss-Prot:P54528" /translation="MSWIVNKQSSQEELAGRFRKLMSAPDILQIPGAHDGMAALLAKE AGFSAIYLSGAAYTASRGLPDLGIITSAEIAERAKDLVRAADLPLLVDIDTGFGGVLN AARTAREMLEARVAAVQMEDQQLPKKCGHLNGKQLVPIKEMAQKIKAIKQAAPSLIVV ARTDARAQEGLDAAIKRSEAYIEAGADAIFPEALQAENEFRQFAERIPVPLLANMTEF GKTPYYRADEFEDMGFHMVIYPVTSLRAAAKACERMFGLMKEHGSQKEGLHDMQTRKE LYDTISYYDYEALDKTIAKTVLPDE*" /label="mmgF CDS" gene complement(2094351..2095256) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /label="mmgF gene" downshifts complement(2094354) /Source="Nicolas_upshifts" /id="D1260" /incds=0 /nref=29 /ntot=69 /MaxReadThrough="2.12559" /MaxDrop="5.62" /score="33.814061" /energy="-11.9" /TU="NA" /idTUdmin="U1884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2095274..2096692) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /EC_number="4.2.1.79" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylcitrate dehydratase (promiscuous)" /protein_id="NP_390293.2" /db_xref="EnsemblGenomes-Gn:BSU24130" /db_xref="EnsemblGenomes-Tr:CAB14344" /db_xref="GOA:P45859" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR012705" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11323" /db_xref="UniProtKB/Swiss-Prot:P45859" /translation="MPKTDRVIEEITDYVLEKEITSAEAYTTAGHVLLDTLGCGILAL RYPECTKLLGPIVPGTTVPNGSKVPGTSYVLDPVRAAFNIGCMIRWLDYNDTWLAAEW GHPSDNLGGILAAADYVSRVRLSEGKEPLTVRDVLEMMIKAHEIQGVLALENSLNRVG LDHVLFVKVATTAVAAKLLGGGREEIKNALSNAWIDNAALRTYRHSPNTGSRKSWAAG DATSRGVHLALMSLKGEMGYPTALSAPGWGFQDVLFNKKEIKLARPLDAYVMENVLFK VSYPAEFHAQTAAESAVILHPQVKNRIDEIDRVVIRTHESAIRIIDKKGPLHNPADRD HCLQYITAIGLLFGDITAQHYEAETANDPRIDKLRDKMEVTENKTYTEDYLKPDKRSI SNAVQVHFKDGTSTEMVECEFPLGHRFRREEAVPKLLEKFSDNLKTHFPDKQHKHIYE RCTSYETLQTMRVNEFVDMFCM*" /label="mmgE CDS" gene complement(2095274..2096692) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /label="mmgE gene" misc_feature complement(2095569..2095588) /Source="Nicolas_upshift_promotors" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2095586) /Source="Nicolas_upshifts" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2096707..2097825) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /EC_number="2.3.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional citrate synthase/2-methylcitrate synthase" /protein_id="NP_390294.1" /db_xref="EnsemblGenomes-Gn:BSU24140" /db_xref="EnsemblGenomes-Tr:CAB14345" /db_xref="GOA:P45858" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG11322" /db_xref="UniProtKB/Swiss-Prot:P45858" /translation="MEEKQHYSPGLDGVIAAETHISYLDTQSSQILIRGYDLIELSET KSYLELVHLLLEGRLPEESEMETLERKINSASSLPADHLRLLELLPEDTHPMDGLRTG LSALAGYDRQIDDRSPSANKERAYQLLGKMPALTAASYRIINKKEPILPLQTLSYSAN FLYMMTGKLPSSLEEQIFDRSLVLYSEHEMPNSTFAARVIASTHSDLYGALTGAVASL KGNLHGGANEAVMYLLLEAKTTSDFEQLLQTKLKRKEKIMGFGHRVYMKKMDPRALMM KEALQQLCDKAGDHRLYEMCEAGERLMEKEKGLYPNLDYYAAPVYWMLGIPIPLYTPI FFSARTSGLCAHVIEQHANNRLFRPRVSYMGPRYQTKS*" /label="mmgD CDS" gene complement(2096707..2097825) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /label="mmgD gene" CDS complement(2097859..2098998) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="propionyl-CoA dehydrogenase subunit" /protein_id="NP_390295.2" /db_xref="EnsemblGenomes-Gn:BSU24150" /db_xref="EnsemblGenomes-Tr:CAB14346" /db_xref="GOA:P45857" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="PDB:5LNX" /db_xref="SubtiList:BG11321" /db_xref="UniProtKB/Swiss-Prot:P45857" /translation="MHVTQEQVMMRKMVRDFARKEIAPAAEIMEKTDEFPFQLIKKMG KHGLMGIPVPEQYGGAGADVVSYILAIHEISRISAAVGVILSVHTSVGTNPILYFGNE EQKMKYIPNLASGDHLGAFALTEPHSGSDAGSLRTTAIKKNGKYLLNGSKIFITNGGA ADIYITFALTAPDQGRHGISAFIVEKNTPGFTVGKKERKLGLYGSNTTELIFDNAEVP EANLLGKEGDGFHIAMANLNVGRIGIAAQALGIAEAALEHAVDYAKQRVQFGRPIAAN QGISFKLADMATRAEAARHLVYHAADLHNRGLNCGKEASMAKQFASDAAVKAALDAVQ IYGGYGYMKDYPVERLLRDAKVTQIYEGTNEIQRLIISKYLLGGT*" /label="mmgC CDS" gene complement(2097859..2098998) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /label="mmgC gene" CDS complement(2099026..2099889) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /EC_number="1.1.1.157" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 18461320, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 18461320, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxybutyryl-CoA dehydrogenase" /protein_id="NP_390296.2" /db_xref="EnsemblGenomes-Gn:BSU24160" /db_xref="EnsemblGenomes-Tr:CAB14347" /db_xref="GOA:P45856" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR006180" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR022694" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11320" /db_xref="UniProtKB/Swiss-Prot:P45856" /translation="MEIKQIMVAGAGQMGSGIAQTAADAGFYVRMYDVNPEAAEAGLK RLKKQLARDAEKGKRTETEVKSVINRISISQTLEEAEHADIVIEAIAENMAAKTEMFK TLDRICPPHTILASNTSSLPITEIAAVTNRPQRVIGMHFMNPVPVMKLVEVIRGLATS EETALDVMALAEKMGKTAVEVNDFPGFVSNRVLLPMINEAIYCVYEGVAKPEAIDEVM KLGMNHPMGPLALADFIGLDTCLSIMEVLHSGLGDSKYRPCPLLRKYVKAGWLGKKSG RGFYDYEEKTS*" /label="mmgB CDS" gene complement(2099026..2099889) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /label="mmgB gene" CDS complement(2099914..2101095) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /EC_number="2.3.1.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16352833, 18246303, 19016856, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352833, 18246303, 19016856, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="degradative acetoacetyl-CoA thiolase" /protein_id="NP_390297.1" /db_xref="EnsemblGenomes-Gn:BSU24170" /db_xref="EnsemblGenomes-Tr:CAB14348" /db_xref="GOA:P45855" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="PDB:5LP7" /db_xref="SubtiList:BG11319" /db_xref="UniProtKB/Swiss-Prot:P45855" /translation="MRKTVIVSAARTPFGKFGGVLKEVKAAELGGIVMKEALQQAGVS GDDVEGNVMGMVVQAGSGQIPSRQAARLAGMPWSVPSETLNKVCASGLRAVTLCDQMI RAQDADILVAGGMESMSNIPYAVPAGRWGARMGDGELRDLMVYDGLTCAFDEVHMAVH GNTAAKEYAISRREQDEWALRSHARAAKAADEGKFQDEIVPVNWIGRKGKPNVVDKDE AIRRDTSLDQLAKLAPIYASDGSITAGNAPGVNDGAGAFVLMSEEKAAELGKRPLATI LGFSTTGMPAHELAAAPGFAINKLLKKNGLTVQDIDLFEVNEAFASVVLTCEKIVGFD LEKVNVNGGAIALGHPIGASGARILMTLVYELKRRGGGLGVAAICSGAAQGDAVLVQV H*" /label="mmgA CDS" gene complement(2099914..2101095) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /label="mmgA gene" downshifts complement(2100675) /Source="Nicolas_upshifts" /id="D1261" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17207" /MaxDrop="2.33167" /score="-0.949614429" /energy="-7.8" /TU="U1884" /idTUdmin="U1885" /TUdmin=550 /isTUend="FALSE" /label="downshifts" misc_feature complement(2100782..2100788) /Source="Nicolas_upshift_promotors" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2100785) /Source="Nicolas_upshifts" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2101009..2101109) /Source="Nicolas_upshift_promotors" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2101049) /Source="Nicolas_upshifts" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2101142..2101160) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2101160) /Source="Nicolas_upshifts" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2101176..2101181) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2101222..2101953) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /EC_number="3.1.4.46" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 14563871, 21966272, 22843846, 24373430, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 14563871, 21966272, 22843846, 24373430, 27780866; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycerophosphodiester phosphodiesterase (exolytic cleavage of individual teichoic acid monomer units)" /protein_id="NP_390298.2" /db_xref="EnsemblGenomes-Gn:BSU24180" /db_xref="EnsemblGenomes-Tr:CAB14349" /db_xref="GOA:P54527" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG11719" /db_xref="UniProtKB/Swiss-Prot:P54527" /translation="MTKIFAHRGASGQFPENTMLAFEKGIEAGADGIELDVQLTKDGR IVVIHDERLNRTTSLKGFVKDTAYDEVKTANAAAGHDQAYSDIKVPLLEDVLSWAVKK DFLINIELKNSVIRYEGMEEKVLEAVKRFNVEDRVILSTFNHDSLALCARLAPHIERA VLTSDVLYQADRYIASIPASGYHPKINSPGVTDEVLKKMRNGLIKVRPYTVNRPEDMK RLIEAGADGMFTDFPEKASALLKNE*" /label="glpQ CDS" gene complement(2101222..2101953) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /label="glpQ gene" downshifts complement(2101229) /Source="Nicolas_upshifts" /id="D1262" /incds=0 /nref=31 /ntot=180 /MaxReadThrough="0.31166" /MaxDrop="4.10202" /score="-0.949614429" /energy="-7.8" /TU="NA" /idTUdmin="U1885" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2101976..2101995) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2101987) /Source="Nicolas_upshifts" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2102010..2102013) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2102032..2102652) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /EC_number="3.5.1.28" /experiment="publication(s) with functional evidences, PMID:22843846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22843846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390299.2" /db_xref="EnsemblGenomes-Gn:BSU24190" /db_xref="EnsemblGenomes-Tr:CAB14350" /db_xref="GOA:P54525" /db_xref="InterPro:IPR002508" /db_xref="SubtiList:BG11717" /db_xref="UniProtKB/Swiss-Prot:P54525" /translation="MRMLWRSLALCGLALTLAPCAQAAEPIEGKTVYIDAGHGGEDSG AVGNGLFEKDINLAVSEHVTDKLKEEGANPVASRSDDHFLTLEERVAKASANQADLFV SIHVNSGVASASGTETYFQSDYEGENSRRLASDIQSQLVSSLQTRDRGVKESDFYVIT YSQMPSVLAELGFITNSSDADKLGSEEYQQKAADAIVNGIDSYYDQ*" /label="yqiI CDS" gene complement(2102032..2102652) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /label="yqiI gene" CDS complement(2102667..2102960) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22843846; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390300.2" /db_xref="EnsemblGenomes-Gn:BSU24200" /db_xref="EnsemblGenomes-Tr:CAB14351" /db_xref="GOA:P40770" /db_xref="SubtiList:BG11030" /db_xref="UniProtKB/Swiss-Prot:P40770" /translation="MKQTVLLLFTALFLSGCSVASADDSVPRFTEEGKYIGSADPHTI AVSLNGEETMIQVPKDKRDECESLPDQTHVLVKYTKKDNGTLQLEDIQLRKNS*" /label="yqiH CDS" gene complement(2102667..2102960) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /label="yqiH gene" promotor_-10 complement(2102980..2102999) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2102986) /Source="Nicolas_upshifts" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2103014..2103021) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2103216..2103223 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2103237..2103256 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2103254..2103459 /Source="Nicolas_S_feature" /locus_tag="new_2516201_2516406" /HighExp="Diami, dia15, dia5, H2O2, Paraq, LBGexp, G180, LBGstat, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99653599999999998" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S911" upshifts 2103254 /Source="Nicolas_upshifts" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2103268..2103420 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513977.1" /translation="MKEVKAMKKFVLLLAAAVITCSIGHQISGGYKGPEKERPKHHSA LKIFSR*" /label="hypothetical protein CDS" gene 2103268..2103420 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /label="gene" promotor_-35 2103428..2103435 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2103450..2103469 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2103461 /Source="Nicolas_upshifts" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2103493..2104611 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-dependent flavin oxidoreductase" /protein_id="NP_390301.1" /db_xref="EnsemblGenomes-Gn:BSU24210" /db_xref="EnsemblGenomes-Tr:CAB14352" /db_xref="GOA:P54524" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11716" /db_xref="UniProtKB/Swiss-Prot:P54524" /translation="MNPKYKPLFEPFTFKSGVTINNRIAVAPMTHYASNEDGTISEAE LDYIIPRSKEMGMVITACANVTPDGKAFPGQPAIHDDSNIPGLKKLAQAIQAQGAKAV VQIHHGGIECPSELVPQQDVVGPSDVFDNGKQIARALTEEEVENIVKAFGEATRRAIE AGFDGVEIHGANGYLIQQFYSPKTNQRTDRWGGSDEKRLAFPLAIVDEVKKAASEHAK GAFLVGYRLSPEEPETPGLTMTETYTLVDALGDKELDYLHISLMDVNSKARRGADPTR TRMDLLNERVGNKVPLIAVGSIHSADDALAVIENGIPLVAMGREILVDPNWTVKVKEG REKQIETVIKGTDKEKYHLPEPLWQAIVNTQGWVPYKD*" /label="yqiG CDS" gene 2103493..2104611 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /label="yqiG gene" downshifts 2104596 /Source="Nicolas_upshifts" /id="D1263" /incds=0 /nref=23 /ntot=181 /MaxReadThrough="1.88324" /MaxDrop="6.67511" /score="30.8551972" /energy="-16.1" /TU="NA" /idTUdmin="U1887" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2104638..2104808) /Source="Nicolas_S_feature" /locus_tag="new_2517585_2517755_c" /HighExp="T0.30H, S6, S8, T1.30H, T1.0H, T-0.40H, S7, Salt, T0.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="1, 0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S912" downshifts complement(2104681) /Source="Nicolas_upshifts" /id="D1264" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="3.46085" /MaxDrop="2.69939" /score="-5.47428449" /energy="-16.1" /TU="U1889" /idTUdmin="U1890" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2104792..2104807) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2104808) /Source="Nicolas_upshifts" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2104810..2104938) /Source="Nicolas_S_feature" /locus_tag="new_2517757_2517885_c" /HighExp="S6, S8, S7, S5, BT, M9-stat, B36, G180, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S913" promotor_-35 complement(2104819..2104828) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2104937..2104956) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2104960) /Source="Nicolas_upshifts" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2104970..2104978) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2105070) /Source="Nicolas_upshifts" /id="D1265" /incds=0 /nref=199 /ntot=267 /MaxReadThrough="2.54843" /MaxDrop="4.82417" /score="-1.10791055" /energy="-15.5" /TU="NA" /idTUdmin="U1891" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2105076..2105879) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT" /protein_id="NP_390302.1" /db_xref="EnsemblGenomes-Gn:BSU24220" /db_xref="EnsemblGenomes-Tr:CAB14353" /db_xref="GOA:P06534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR012052" /db_xref="InterPro:IPR014879" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1LQ1" /db_xref="SubtiList:BG10765" /db_xref="UniProtKB/Swiss-Prot:P06534" /translation="MEKIKVCVADDNRELVSLLSEYIEGQEDMEVIGVAYNGQECLSL FKEKDPDVLVLDIIMPHLDGLAVLERLRESDLKKQPNVIMLTAFGQEDVTKKAVDLGA SYFILKPFDMENLVGHIRQVSGNASSVTHRAPSSQSSIIRSSQPEPKKKNLDASITSI IHEIGVPAHIKGYLYLREAISMVYNDIELLGSITKVLYPDIAKKFNTTASRVERAIRH AIEVAWSRGNIDSISSLFGYTVSMTKAKPTNSEFIAMVADKLRLEHKAS*" /label="spo0A CDS" gene complement(2105076..2105879) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /label="spo0A gene" promotor_-10 complement(2105922..2105940) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2105928) /Source="Nicolas_upshifts" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2105930..2106082) /Source="Nicolas_S_feature" /locus_tag="new_2518877_2519029_c" /HighExp="T1.30H, T3.0H, T2.30H, T2.0H, HiTm, Lbtran, T1.0H, T-0.40H, T0.30H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S914" promotor_-35 complement(2105951..2105959) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2106078..2106097) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2106090) /Source="Nicolas_upshifts" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2106109..2106116) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2106155..2107435) /gene="spoIVB" /locus_tag="BSU_24230" /old_locus_tag="BSU24230" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12218026, 15292188, 16164552, 16238631, 16818230, 17493131, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12218026, 15292188, 16164552, 16238631, 16818230, 17493131, 17557826; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="regulatory membrane-associated serine protease" /protein_id="NP_390303.2" /db_xref="EnsemblGenomes-Gn:BSU24230" /db_xref="EnsemblGenomes-Tr:CAB14354" /db_xref="GOA:P17896" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008763" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR014219" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG10311" /db_xref="UniProtKB/Swiss-Prot:P17896" /translation="MPDNIRKAVGLILLVSLLSVGLCKPLKEYLLIPTQMRVFETQTQ AIETSLSVNAQTSESSEAFTVKKDPHEIKVTGKKSGESELVYDLAGFPIKKTKVHVLP DLKVIPGGQSIGVKLHSVGVLVVGFHQINTSEGKKSPGETAGIEAGDIIIEMNGQKIE KMNDVAPFIQKAGKTGESLDLLIKRDKQKIKTKLIPEKDEGEGKYRIGLYIRDSAAGI GTMTFYEPKTKKYGALGHVISDMDTKKPIVVENGEIVKSTVTSIEKGTGGNPGEKLAR FSSERKTIGDINRNSPFGIFGTLHQPIQNNISDQALPVAFSTEVKKGPAEILTVIDDD KVEKFDIEIVSTTPQKFPATKGMVLKITDPRLLKETGGIVQGMSGSPIIQNGKVIGAV THVFVNDPTSGYGVHIEWMLSEAGIDIYGKEKAS*" /label="spoIVB CDS" gene complement(2106155..2107435) /gene="spoIVB" /locus_tag="BSU_24230" /old_locus_tag="BSU24230" /label="spoIVB gene" downshifts complement(2106170) /Source="Nicolas_upshifts" /id="D1266" /incds=0 /nref=34 /ntot=51 /MaxReadThrough="1.04939" /MaxDrop="7.80695" /score="49.1812184" /energy="-12.5" /TU="NA" /idTUdmin="U1893" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2107496..2107507) /Source="Nicolas_upshift_promotors" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2107510) /Source="Nicolas_upshifts" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2107522..2107528) /Source="Nicolas_upshift_promotors" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2107610..2109340) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /function="16.8: Protect" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor for double strand breaks DNA repair and genetic recombination" /protein_id="NP_390304.2" /db_xref="EnsemblGenomes-Gn:BSU24240" /db_xref="EnsemblGenomes-Tr:CAB14355" /db_xref="GOA:P17894" /db_xref="InterPro:IPR004604" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10310" /db_xref="UniProtKB/Swiss-Prot:P17894" /translation="MLAELSIKNFAIIEELTVSFERGLTVLTGETGAGKSIIIDAISL LVGGRGSSEFVRYGEAKAELEGLFLLESGHPVLGVCAEQGIDVSDEMIVMRRDISTSG KSVCRVNGKLVTIASLREIGRLLLDIHGQHDNQLLMEDENHLQLLDKFAGAEVESALK TYQEGYQRYVKLLKKLKQLSESEQEMAHRLDLIQFQLEEIESAKLELNEDEQLQEERQ QISNFEKIYESLQNAYNALRSEQGGLDWVGMASAQLEDISDINEPLKKMSESVSNSYY LLEDATFQMRNMLDELEFDPERLNYIETRLNEIKQLKRKYGATVEDILEYASKIEEEI DQIENRDSHLQSLKKELDSVGKDVAVEAANVSQIRKTWAKKLADEIHRELKSLYMEKS TFDTEFKVRTASRNEEAPLVNGQPVQLTEQGIDLVKFLISTNTGEPLKSLSKVASGGE LSRVMLAIKSIFSSQQDVTSIIFDEVDTGVSGRVAQAIAEKIHKVSIGSQVLCITHLP QVAAMADTHLYIAKELKDGRTTTRVKPLSKQEKVAEIGRMIAGVEVTDLTKRHAKELL KQADQVKTTG*" /label="recN CDS" gene complement(2107610..2109340) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /label="recN gene" downshifts complement(2107625) /Source="Nicolas_upshifts" /id="D1267" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="1.73202" /MaxDrop="6.33427" /score="20.028822" /energy="-12.4" /TU="NA" /idTUdmin="U1895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2109377..2109826) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AhrC(ArgR)-arginine)" /protein_id="NP_390305.1" /db_xref="EnsemblGenomes-Gn:BSU24250" /db_xref="EnsemblGenomes-Tr:CAB14356" /db_xref="GOA:P17893" /db_xref="InterPro:IPR001669" /db_xref="InterPro:IPR020899" /db_xref="InterPro:IPR020900" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR036251" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1F9N" /db_xref="PDB:2P5K" /db_xref="PDB:2P5L" /db_xref="PDB:2P5M" /db_xref="SubtiList:BG10309" /db_xref="UniProtKB/Swiss-Prot:P17893" /translation="MNKGQRHIKIREIITSNEIETQDELVDMLKQDGYKVTQATVSRD IKELHLVKVPTNNGSYKYSLPADQRFNPLSKLKRALMDAFVKIDSASHMIVLKTMPGN AQAIGALMDNLDWDEMMGTICGDDTILIICRTPEDTEGVKNRLLELL*" /label="argR CDS" gene complement(2109377..2109826) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /label="argR gene" S_feature complement(2109827..2109912) /Source="Nicolas_S_feature" /locus_tag="new_2522774_2522859_c" /HighExp="H2O2, G180, G135, G150, Oxctl, Heat, Paraq, C30, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S915" CDS complement(2109924..2110769) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /EC_number="2.1.1.-" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2'-O-ribose RNA methyltransferase" /protein_id="NP_390306.2" /db_xref="EnsemblGenomes-Gn:BSU24260" /db_xref="EnsemblGenomes-Tr:CAB14357" /db_xref="GOA:P19672" /db_xref="InterPro:IPR002877" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR004538" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10308" /db_xref="UniProtKB/Swiss-Prot:P19672" /translation="MTSKKERLDVLLVERGLAETREKAKRAIMAGIVYSNENRLDKPG EKIDRDLPLTVKGNPLRYVSRGGLKLEKALKEFPVSVKDKIMIDIGSSTGGFTDCALQ NGAKQSYAVDVGYNQLAWKLRQDERVVVMERTNFRYATPADFTKGMPEFATIDVSFIS LRLILPVLRTLLVPGSDCMALVKPQFEAGRESVGKKGIVRDPKVHADVLKRMISFSAA EGYICKGLSFSPITGGDGNIEFLLHLHWPGEGQEGQELPEEEIMRVVEEAHKTLKEKK ADVPE*" /label="yqxC CDS" gene complement(2109924..2110769) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /label="yqxC gene" downshifts complement(2109957) /Source="Nicolas_upshifts" /id="D1268" /incds=0 /nref=1 /ntot=65 /MaxReadThrough="5.65358" /MaxDrop="2.6955" /score="4.97422627" /energy="-9.4" /TU="U1895,U1896,U1898" /idTUdmin="U1895" /TUdmin="-2332" /isTUend="FALSE" /label="downshifts" CDS complement(2110766..2112667) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /EC_number="2.2.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12882400, 15292217, 17458547, 23840410, 25212876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-deoxyxylulose-5-phosphate synthase" /protein_id="NP_390307.1" /db_xref="EnsemblGenomes-Gn:BSU24270" /db_xref="EnsemblGenomes-Tr:CAB14358" /db_xref="GOA:P54523" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005477" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11715" /db_xref="UniProtKB/Swiss-Prot:P54523" /translation="MDLLSIQDPSFLKNMSIDELEKLSDEIRQFLITSLSASGGHIGP NLGVVELTVALHKEFNSPKDKFLWDVGHQSYVHKLLTGRGKEFATLRQYKGLCGFPKR SESEHDVWETGHSSTSLSGAMGMAAARDIKGTDEYIIPIIGDGALTGGMALEALNHIG DEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKKIPAVGGKL AATAERVKDSLKYMLVSGMFFEELGFTYLGPVDGHSYHELIENLQYAKKTKGPVLLHV ITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSGLVSGTVQRMAREDG RIVAITPAMPVGSKLEGFAKEFPDRMFDVGIAEQHAATMAAAMAMQGMKPFLAIYSTF LQRAYDQVVHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFMRHIPNMVLMMPKD ENEGQHMVHTALSYDEGPIAMRFPRGNGLGVKMDEQLKTIPIGTWEVLRPGNDAVILT FGTTIEMAIEAAEELQKEGLSVRVVNARFIKPIDEKMMKSILKEGLPILTIEEAVLEG GFGSSILEFAHDQGEYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKQQVANRIRLLMP PKTHKGIGS*" /label="dxs CDS" gene complement(2110766..2112667) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /label="dxs gene" promotor_-35 2111875..2111881 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2111896..2111907 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2111904 /Source="Nicolas_upshifts" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2112668..2112796) /Source="Nicolas_S_feature" /locus_tag="new_2525615_2525743_c" /HighExp="Salt, Heat, dia15, H2O2, HiOs, Cold, T-5.40H, T3.30H, SMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S916" promotor_-10 complement(2112791..2112810) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2112796) /Source="Nicolas_upshifts" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2112825..2112831) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2112842..2113732) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /EC_number="2.5.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755734, 12682299, 17147392, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate synthase" /protein_id="NP_390308.2" /db_xref="EnsemblGenomes-Gn:BSU24280" /db_xref="EnsemblGenomes-Tr:CAB14359" /db_xref="GOA:P54383" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG11714" /db_xref="UniProtKB/Swiss-Prot:P54383" /translation="MTNKLTSFLADRKKTIENQLSVYTEKLDMPDSLKKSMLYSLQAG GKRLRPLIVLAVLNAYGKSEKDGIPVGCAVEMIHTYSLIHDDLPCMDDDDLRRGKPTN HKVFGEATAVLAGDGLLTESFKLITSHVSDEVSAEKRLRLVNELISAAGTEGMVGGQV ADMEAENRQVTLEELESIHERKTAKLLGFCVIAGAILADAPEEDIETLRTFSSHIGIG FQIRDDILDLEGSEEKIGKRVGSDTTNDKSTYPSLLSLEGAKHKLDVHIKEAKRLIGG LSLQKDLLYELCDLIAARDH*" /label="ispA CDS" gene complement(2112842..2113732) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /label="ispA gene" CDS complement(2113722..2113976) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /EC_number="3.1.11.6" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11381137, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (small subunit)" /protein_id="NP_390309.2" /db_xref="EnsemblGenomes-Gn:BSU24290" /db_xref="EnsemblGenomes-Tr:CAB14360" /db_xref="GOA:P54522" /db_xref="InterPro:IPR003761" /db_xref="InterPro:IPR037004" /db_xref="SubtiList:BG11713" /db_xref="UniProtKB/Swiss-Prot:P54522" /translation="MTDVKKNENMTFEEAMKGLESIVSKLEEGDVPLEQAINYFQEGM ALSKMCHEKLQKVEKQMDFILKEDGELAPFSVQEEDEGDK*" /label="xseB CDS" gene complement(2113722..2113976) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /label="xseB gene" CDS complement(2113973..2115319) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /EC_number="3.1.11.6" /function="16.9: Replicate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17182742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (large subunit)" /protein_id="NP_390310.2" /db_xref="EnsemblGenomes-Gn:BSU24300" /db_xref="EnsemblGenomes-Tr:CAB14361" /db_xref="GOA:P54521" /db_xref="InterPro:IPR003753" /db_xref="InterPro:IPR020579" /db_xref="InterPro:IPR025824" /db_xref="SubtiList:BG11712" /db_xref="UniProtKB/Swiss-Prot:P54521" /translation="MGEAAYVTVSALTKYIKRKFDVDPHLENIWIKGELSNVKIHTRG HIYFTLKDENARMQSVMFARQSERLPFKPENGMKVLVRGGISVYEPSGNYQLYAKEMQ PDGVGALYLAYEELKKKLAGEGLFDDRYKKQIPAFPATIGVVTSPTGAAVRDVITTLK RRYPLVKVIVLPALVQGENASRSIVTRIEEANEKEICDVLIVGRGGGSIEELWAFNEE IVARAIFASNIPIISAVGHETDFTISDFVADIRAATPTGAAEIAVPHTTDLIERTKTA EVRMTRAMQQHLGQKKERIQTLQSSYAFRFPKRLYAQKEQQFDLAYQQFQAQLTALLD RKSRQLERETYRLEALHPHEQLKQARTRYQEQTNQLRKNMNIQMKQLHSQFQTVLGKL NALSPLQVMERGYSLAYKEDKLIKSVSQIEEQDRLEIKLKDGVLTCEVLEKRGEEK*" /label="xseA CDS" gene complement(2113973..2115319) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /label="xseA gene" S_feature complement(2115320..2115456) /Source="Nicolas_S_feature" /locus_tag="new_2528267_2528403_c" /HighExp="H2O2, G180, G135, Cold, G150, Paraq, Oxctl, LBGstat, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S917" CDS complement(2115457..2116308) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /EC_number="1.5.1.5" /EC_number="3.5.4.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7061514, 9454603, 12682299, 19171795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase" /protein_id="NP_390311.1" /db_xref="EnsemblGenomes-Gn:BSU24310" /db_xref="EnsemblGenomes-Tr:CAB14362" /db_xref="GOA:P54382" /db_xref="InterPro:IPR000672" /db_xref="InterPro:IPR020630" /db_xref="InterPro:IPR020631" /db_xref="InterPro:IPR020867" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11711" /db_xref="UniProtKB/Swiss-Prot:P54382" /translation="MTATIIDGKETAREKREQLAKEVEELKKQGVTPGLAVILIGDDP ASHSYVRGKKKAAETMGMNFKLDQFDSSLTEAELLSIIDQYNQDPEFHGILVQLPLPD HISEKAVIERISPDKDVDGFHPLNVGKMLLGEDTFLPCTPHGIVELLKKTNIDLSGKE VVVVGRSNIVGKPVGQLLLNENATVTYCHSRTENITEHTKKADILVVAVGRANFISAD QIKEGAVVIDVGVNRLENGKLCGDVEFEGAKEKASFITPVPGGVGPMTITMLAHNTVK SAKRTLS*" /label="folD CDS" gene complement(2115457..2116308) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /label="folD gene" CDS complement(2116320..2116715) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16707701, 16946247, 27964882; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription termination factor NusB" /protein_id="NP_390312.2" /db_xref="EnsemblGenomes-Gn:BSU24320" /db_xref="EnsemblGenomes-Tr:CAB14363" /db_xref="GOA:P54520" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR011605" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG11710" /db_xref="UniProtKB/Swiss-Prot:P54520" /translation="MKRRTAREKALQALFQIDVSDIAVNEAIEHALDEEKTDPFFEQL VHGVLEHQDQLDEMISKHLVNWKLDRIANVDRAILRLAAYEMAYAEDIPVNVSMNEAI ELAKRFGDDKATKFVNGVLSNIKSDIEQS*" /label="nusB CDS" gene complement(2116320..2116715) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /label="nusB gene" misc_feature complement(2116758..2116777) /Source="Nicolas_upshift_promotors" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2116777) /Source="Nicolas_upshifts" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2116779..2116941) /Source="Nicolas_S_feature" /locus_tag="new_2529726_2529888_c" /HighExp="G180, G150, Oxctl, Etha, G135, GM 120, dia0, HPh, MG 150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S918" CDS complement(2116979..2117386) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 17114254, 22720735, 28579978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 17114254, 22720735, 28579978; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="alkaline shock protein" /protein_id="NP_390313.2" /db_xref="EnsemblGenomes-Gn:BSU24330" /db_xref="EnsemblGenomes-Tr:CAB14364" /db_xref="InterPro:IPR005531" /db_xref="SubtiList:BG11709" /db_xref="UniProtKB/Swiss-Prot:P54519" /translation="MKDNSLLKMDHEDTHLGKVEIAPEVIEVIAGIAASEVDGVAEMR GNFATGVVERFGKVNHGKGVKVDLADDGITIDVYCVVTFGVSIPKVAASVQENIRQTL LNMTSLSINEINIHIVGIQFDTKAQEVQIDEEM*" /label="yqhY CDS" gene complement(2116979..2117386) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /label="yqhY gene" downshifts complement(2116986) /Source="Nicolas_upshifts" /id="D1269" /incds=0 /nref=6 /ntot=76 /MaxReadThrough="6.4099" /MaxDrop="4.1473" /score="9.44795832" /energy="-9.5" /TU="U1897,U1898" /idTUdmin="U1899" /TUdmin=2409 /isTUend="FALSE" /label="downshifts" CDS complement(2117407..2118759) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /EC_number="6.3.4.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxylase subunit)" /protein_id="NP_390314.2" /db_xref="EnsemblGenomes-Gn:BSU24340" /db_xref="EnsemblGenomes-Tr:CAB14365" /db_xref="GOA:P49787" /db_xref="InterPro:IPR004549" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11384" /db_xref="UniProtKB/Swiss-Prot:P49787" /translation="MIKKLLIANRGEIAVRIIRACRELGIETVAVYSEADKDALHVQM ADEAFCIGPKASKDSYLNVTNIVSVAKLTGTDAIHPGYGFLAENADFAELCEEVNVTF VGPSADAISKMGTKDVARETMKQAGVPIVPGSQGIIENVEEAVSLANEIGYPVIIKAT AGGGGKGIRVARTEEELINGIKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNY GNTIHLGERDCSIQRRLQKLLEESPSPALDSEIREQMGDAAVKAAKAVGYTGAGTVEF IYDYNEQRYYFMEMNTRIQVEHPVTEMVTGTDLIKEQIKVASGMELSLKQEDVEFEGW AIECRINAENPSKNFMPSPGEIKMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVIT YGKTRDEAIARMKRALSEFVIEGIETTIPFHLKLLEHETFVSGEFNTKFLETYDVMGS *" /label="accC CDS" gene complement(2117407..2118759) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /label="accC gene" promotor_-10 complement(2118288..2118307) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-10" upshifts complement(2118295) /Source="Nicolas_upshifts" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="upshifts" promotor_-35 complement(2118322..2118328) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-35" CDS complement(2118771..2119250) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796, 15518551" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796, 15518551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxyl carrier subunit)" /protein_id="NP_390315.1" /db_xref="EnsemblGenomes-Gn:BSU24350" /db_xref="EnsemblGenomes-Tr:CAB14366" /db_xref="GOA:P49786" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001249" /db_xref="InterPro:IPR001882" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG11383" /db_xref="UniProtKB/Swiss-Prot:P49786" /translation="MLNIKEIHELIKAIDESTIDEFVYENEGVSLKLKKHEAGTVQVM QQAPAAPVQAQAPQAVQPQAQQAAAPAQEAPKQDENLHKITSPMVGTFYASSSPEAGP YVTAGSKVNENTVVCIVEAMKLFNEIEAEVKGEIVEVLVENGQLVEYGQPLFLVKAE* " /label="accB CDS" gene complement(2118771..2119250) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /label="accB gene" promotor_-10 complement(2119309..2119328) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2119320) /Source="Nicolas_upshifts" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2119342..2119349) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2119406..2120062) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15028710, 15752199, 16959571, 1766372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15028710, 15752199, 16959571, 1766372; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation ratchet engulfment protein" /protein_id="NP_390316.2" /db_xref="EnsemblGenomes-Gn:BSU24360" /db_xref="EnsemblGenomes-Tr:CAB14367" /db_xref="GOA:P49785" /db_xref="InterPro:IPR024232" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11415" /db_xref="UniProtKB/Swiss-Prot:P49785" /translation="MLKKQTVWLLTMLSLVVVLSVYYIMSPESKNAVQMQSEKSASDS GEVATEKAPAKQDTKEKSGTETEKGKEDGTKGTKDSSADKETSAEASEKGTVVTETAD DDLFTTYRLDLEDARSKEREELNAIVSSDDATAKEKSEAYDKMTALSEVEGTEKQLET LIKTQGYEDALVNAEGDKINITVKSDKHSKSKATAIIDLVAKEIKTMKDVAVTFEPSK *" /label="spoIIIAH CDS" gene complement(2119406..2120062) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /label="spoIIIAH gene" downshifts complement(2119413) /Source="Nicolas_upshifts" /id="D1270" /incds=0 /nref=26 /ntot=57 /MaxReadThrough="0.0903599999999987" /MaxDrop="6.40434" /score="21.0450747" /energy="-13" /TU="NA" /idTUdmin="U1899" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" CDS complement(2120063..2120752) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation engulfment assembly protein" /protein_id="NP_390317.2" /db_xref="EnsemblGenomes-Gn:BSU24370" /db_xref="EnsemblGenomes-Tr:CAB14368" /db_xref="GOA:P49784" /db_xref="InterPro:IPR014195" /db_xref="SubtiList:BG11414" /db_xref="UniProtKB/Swiss-Prot:P49784" /translation="MNKNGLWNVLKKQFLPGQTKDGEKPKLTKYHYFLFVFVLGVSFM LVSQLFSSPEKTENAKTITAVSSQHSADSKEKTAEVFKASKSDKPKDSIDDYEKEYEN QLKEILETIIGVDDVSVVVNVDATSLKVYEKNKSNKNTTTEETDKEGGKRSVTDQSSE EEIVMIKNGDKETPVVVQTKKPDIRGVLVVAQGVDNVQIKQTIIEAVTRVLDVPSHRV AVAPKKIKEDS*" /label="spoIIIAG CDS" gene complement(2120063..2120752) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /label="spoIIIAG gene" CDS complement(2120745..2121365) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390318.1" /db_xref="EnsemblGenomes-Gn:BSU24380" /db_xref="EnsemblGenomes-Tr:CAB14369" /db_xref="GOA:P49783" /db_xref="InterPro:IPR014245" /db_xref="SubtiList:BG11413" /db_xref="UniProtKB/Swiss-Prot:P49783" /translation="MSFLTEWLTTIVLFILFAIVIDMLLPSSSMQKYAKMVVSLLLIV VMLTPIFKLFKTDPEVIFEYLTKNGQSESADIKNQINSKKIEIQASQRAYILEEMAVQ LKKKAEERFSHDEYKVGRIKLTAGEKVDSEEDIKTISVYMAPSSEKTVQTVAPVHIDT DHAYVTKEAAEQKEAKQIQTQLADIWEIGSEKITVHMEGGESVGNE*" /label="spoIIIAF CDS" gene complement(2120745..2121365) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /label="spoIIIAF gene" promotor_-10 complement(2121071..2121089) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2121089) /Source="Nicolas_upshifts" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2121105..2121110) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2121379..2122578) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390319.2" /db_xref="EnsemblGenomes-Gn:BSU24390" /db_xref="EnsemblGenomes-Tr:CAB14370" /db_xref="GOA:P49782" /db_xref="InterPro:IPR014194" /db_xref="SubtiList:BG11412" /db_xref="UniProtKB/Swiss-Prot:P49782" /translation="MKRFQWVLLLAVLIIAGRAEIVQAAGNAEQTEDHAETAEQLAER TAASLETDKIGEFWNDIMTEYGGLLPESQKGSLMEFINGDKSFSPQEWLKALFSYLFH EVLANGKLLGTLILLTIFCVILQLLQNAFQQSTVSKVAYSIVYMVLIILALNSFHVAI NYATEAIQTMTSFILALIPLLLALLASSGGAVSAAFFHPVILFLMNTSGLLIQNIVMP LIFLSAILSIVSTMTEQYKVTQLANLLRNIAIGALAVFLTIFLGVISVQGASAAVTDG ITLRTAKFITGNFIPVLGRMFTDATDTVISASLLLKNTVGILGVAILICIAAFPAIKV LSLAFIYKLAAAILQPLGGGPVITCLDVISKSVIYIFAALAIVSLMFFLSLTVIITAG NLTMMMK*" /label="spoIIIAE CDS" gene complement(2121379..2122578) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /label="spoIIIAE gene" CDS complement(2122597..2122998) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390320.1" /db_xref="EnsemblGenomes-Gn:BSU24400" /db_xref="EnsemblGenomes-Tr:CAB14371" /db_xref="GOA:P49781" /db_xref="InterPro:IPR014211" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11411" /db_xref="UniProtKB/Swiss-Prot:P49781" /translation="MQIDIVQIVGLGLIATFLSLIVKEQKPTFAFLIVVFAGCAIFLY LVDQIYDIIRMIEKIAINANVNMVYVETILKIIGIAYIAEFGAQLTKDAGQGAIASKI ELAGKILILVMAVPILTVIIETILGLIPSMS*" /label="spoIIIAD CDS" gene complement(2122597..2122998) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /label="spoIIIAD gene" CDS complement(2123005..2123211) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390321.1" /db_xref="EnsemblGenomes-Gn:BSU24410" /db_xref="EnsemblGenomes-Tr:CAB14372" /db_xref="GOA:P49780" /db_xref="InterPro:IPR009570" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11410" /db_xref="UniProtKB/Swiss-Prot:P49780" /translation="MGVDVNVIFQIAGVGIVVAFLHTILDQMGKKEYAQWVTLLGFIY ILFMVATIVDDLFKKIKAVFLFQG*" /label="spoIIIAC CDS" gene complement(2123005..2123211) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /label="spoIIIAC gene" CDS complement(2123234..2123749) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390322.1" /db_xref="EnsemblGenomes-Gn:BSU24420" /db_xref="EnsemblGenomes-Tr:CAB14373" /db_xref="GOA:Q01368" /db_xref="InterPro:IPR014198" /db_xref="SubtiList:BG10541" /db_xref="UniProtKB/Swiss-Prot:Q01368" /translation="MLKLLGAVFIVVATTWTGFEMAKIYTERPRQIRQLRAALQSLEA EIMYGHTPLHTASQQIAKQLAQPVSTLFSAFSDQLDKGSDSAKTAWEQSLKKVWDTLS LKKSEYEVLKQFGETLGIHDRISQQKHIKLALTHLEASEADAEQAQAKNEKMIKSLGF LAGLLLILLLM*" /label="spoIIIAB CDS" gene complement(2123234..2123749) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /label="spoIIIAB gene" CDS complement(2123743..2124666) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATP-binding stage III sporulation protein" /protein_id="NP_390323.1" /db_xref="EnsemblGenomes-Gn:BSU24430" /db_xref="EnsemblGenomes-Tr:CAB14374" /db_xref="GOA:Q01367" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR014217" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10540" /db_xref="UniProtKB/Swiss-Prot:Q01367" /translation="MNEIAEVLPESMKNALSEIPEQQWLEIEEVRIRINRPVELIRRG QPVYLSYAGTAEDAHLILSRLSNYSMYTLEEELKKGYVTIRGGHRVGLAGRVITENGG VKGLRDIASFNIRIARQKLGIAEPLLPYLYQNSWLNTLIIGPPQTGKTTLLRDLARLS STGKKNMLPVKTGIVDERSEIAGCLRGIPQHQFGQRIDVLDACPKAEGLMMMIRSMSP EVMIVDEIGRMEDTDALLEALHAGVSVIVSAHGWSISDLMKRPSLKRLWEERAFDRYL ELSRAKGPGTVSQIYDKDGNVLSRTTGVKTC*" /label="spoIIIAA CDS" gene complement(2123743..2124666) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /label="spoIIIAA gene" S_feature complement(2124667..2124741) /Source="Nicolas_S_feature" /locus_tag="new_2537614_2537688_c" /HighExp="S3, LoTm, S4, T5.0H, M9-stat, S5, BT, S7, S6, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S919" CDS complement(2124742..2125023) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390324.1" /db_xref="EnsemblGenomes-Gn:BSU24440" /db_xref="EnsemblGenomes-Tr:CAB14375" /db_xref="GOA:P49779" /db_xref="InterPro:IPR020390" /db_xref="SubtiList:BG11459" /db_xref="UniProtKB/Swiss-Prot:P49779" /translation="MKFLLGNINSTVLTMAGLRVLSSMIELTAAIVMLVTNDVRKAVV VNSILAIVGPLIFIITMTVGIYQIAGQLSYAKLILIFTGVVLILAGVHK*" /label="yqhV CDS" gene complement(2124742..2125023) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /label="yqhV gene" promotor_-10 complement(2125043..2125061) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-10" upshifts complement(2125066) /Source="Nicolas_upshifts" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="upshifts" promotor_-35 complement(2125077..2125082) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-35" CDS complement(2125168..2125725) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor P" /protein_id="NP_390325.2" /db_xref="EnsemblGenomes-Gn:BSU24450" /db_xref="EnsemblGenomes-Tr:CAB14376" /db_xref="GOA:P49778" /db_xref="InterPro:IPR001059" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR011768" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013185" /db_xref="InterPro:IPR013852" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015365" /db_xref="InterPro:IPR020599" /db_xref="SubtiList:BG11460" /db_xref="UniProtKB/Swiss-Prot:P49778" /translation="MISVNDFRTGLTIEVDGGIWRVVDFQHVKPGKGAAFVRSKLRNL RTGAIQEKTFRAGEKVAKAQIETKTMQYLYANGDQHVFMDTSSYEQLELSATQIEEEL KYLLENMSVHIMMYQDETLGIELPNTVELKVVETEPGIKGDTASGGTKPAKTETGLVV NVPFFVNEGDTLVVNTSDGSYVSRA*" /label="efp CDS" gene complement(2125168..2125725) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /label="efp gene" downshifts complement(2125180) /Source="Nicolas_upshifts" /id="D1271" /incds=0 /nref=256 /ntot=266 /MaxReadThrough="0.83852" /MaxDrop="7.73118" /score="27.4193827" /energy="-13.5" /TU="NA" /idTUdmin="U1901" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2125750..2126811) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /EC_number="3.4.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23144141, 26735940, 27002156" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23144141, 26735940, 27002156; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase (Met-Xaa and Xaa-Pro, Xaa-Pro-Xaa)" /protein_id="NP_390326.1" /db_xref="EnsemblGenomes-Gn:BSU24460" /db_xref="EnsemblGenomes-Tr:CAB14377" /db_xref="GOA:P54518" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG11708" /db_xref="UniProtKB/Swiss-Prot:P54518" /translation="MKLEKLRNLFGQLGIDGMLITSNTNVRYMTGFTGSAGLAVISGD KAAFITDFRYTEQAKVQVKGFEIIEHGGSLIQTTADTVESFGIKRLGFEQNSMTYGTY ASYSAVISDAELVPVAESVEKLRLIKSSEEIKILEEAAKIADDAFRHILTFMKPGISE IAVANELEFYMRSQGADSSSFDMIVASGLRSSLPHGVASDKLIESGDLVTLDFGAYYK GYCSDITRTVAVGQPSDQLKEIYQVVFDAQALGVAHIKPGMTGKEADALTRDHIAAKG YGDYFGHSTGHGLGMEVHESPGLSVRSSAILEPGMVVTVEPGIYIPETGGVRIEDDIV ITENGNRTITHSPKELIIL*" /label="papA CDS" gene complement(2125750..2126811) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /label="papA gene" CDS complement(2126808..2127254) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10870960, 19099550; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase, type II" /protein_id="NP_390327.1" /db_xref="EnsemblGenomes-Gn:BSU24470" /db_xref="EnsemblGenomes-Tr:CAB14378" /db_xref="GOA:P54517" /db_xref="InterPro:IPR001874" /db_xref="InterPro:IPR018509" /db_xref="InterPro:IPR036441" /db_xref="PDB:1GQO" /db_xref="SubtiList:BG11707" /db_xref="UniProtKB/Swiss-Prot:P54517" /translation="MPHFLILNGPNVNRLGSREPEVFGRQTLTDIETDLFQFAEALHI QLTFFQSNHEGDLIDAIHEAEEQYSGIVLNPGALSHYSYAIRDAVSSISLPVVEVHLS NLYAREEFRHQSVIAPVAKGQIVGLGAEGYKLAVRYLLSQQGGESR*" /label="yqhS CDS" gene complement(2126808..2127254) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /label="yqhS gene" promotor_-10 complement(2127303..2127322) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2127319) /Source="Nicolas_upshifts" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2127335..2127342) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2127341..2127877) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390328.1" /db_xref="EnsemblGenomes-Gn:BSU24480" /db_xref="EnsemblGenomes-Tr:CAB14379" /db_xref="GOA:P54516" /db_xref="InterPro:IPR024563" /db_xref="SubtiList:BG11706" /db_xref="UniProtKB/Swiss-Prot:P54516" /translation="MMTSEKDTEQNEELNEKQKPPVSMAGRVAATGFCGGVLWSFVAY IAYLFHFSEISPNMILQPFVLGEWKKHGLGTVISIILIGVISIGAAFLYFLLLKRLKT MWPGILYGLVLWLLVFFVFNPIFPDVRTVTELTSDTIITTICIYLLYGLFVGYSISFE YNELNSEKLARALGMHRE*" /label="yqhR CDS" gene complement(2127341..2127877) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /label="yqhR gene" promotor_-10 complement(2127890..2127901) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-10" upshifts complement(2127899) /Source="Nicolas_upshifts" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="upshifts" promotor_-35 complement(2127915..2127921) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-35" promotor_-35 2127947..2127953 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2127966 /Source="Nicolas_upshifts" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2127968..2127986 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2128023..2128026 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2128041..2128060 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2128052 /Source="Nicolas_upshifts" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" CDS 2128104..2129060 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390329.2" /db_xref="EnsemblGenomes-Gn:BSU24490" /db_xref="EnsemblGenomes-Tr:CAB14380" /db_xref="GOA:P54515" /db_xref="InterPro:IPR010787" /db_xref="SubtiList:BG11705" /db_xref="UniProtKB/Swiss-Prot:P54515" /translation="MSKHKVPPAYGGQAVVEGVMFGGKHHYVTAIRRTDGSIDFFKLP RKHNPKLNIVKKIPFLRGIAAIIEASANGTKHLNFSSERYGLDPSEDETLEQEEKKSS GLSMYLSLAVIGVLSFLFSKFVFTLVPVFLAELTRPIFSLNTAQIAIESLFKLILLLG YIYFLSMTPLIKRVFQYHGAEHKVINCYEQNLPITVENVQNQSRLHYRCGSSFILFTI IVGMFVYLLVPTDPLWLRVIDRVALIPVVLGISFEVLQLTNKVRDIPGLKLLGYPGLW LQLLTTKEPKDEQVEVAIESFNELLRLEALSEQNQKPSHNVI*" /label="yqhQ CDS" gene 2128104..2129060 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /label="yqhQ gene" CDS 2129100..2129495 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390330.1" /db_xref="EnsemblGenomes-Gn:BSU24500" /db_xref="EnsemblGenomes-Tr:CAB14381" /db_xref="GOA:P54514" /db_xref="SubtiList:BG11704" /db_xref="UniProtKB/Swiss-Prot:P54514" /translation="MNHRVQPIIAVLIALGAFGFLYVLVTNPGEMAKMAVTVIVAGII IYFIVKYVMNRNAGSEGAAFKKAAKQSRRRMKEQKAKHRAGHKGRVSHLRSVPSASKP KPMILKKKSQTQLTVIEGKKNKKKNRALF*" /label="yqhP CDS" gene 2129100..2129495 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /label="yqhP gene" promotor_no_box 2129378..2129478 /Source="Nicolas_upshift_promotors" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2129438 /Source="Nicolas_upshifts" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2129481 /Source="Nicolas_upshifts" /id="D1272" /incds=0 /nref=116 /ntot=283 /MaxReadThrough="2.23161" /MaxDrop="5.94415" /score="29.0609078" /energy="-8" /TU="NA" /idTUdmin="U1903" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2129492..2130367) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipase / acyl esterase" /protein_id="NP_390331.1" /db_xref="EnsemblGenomes-Gn:BSU24510" /db_xref="EnsemblGenomes-Tr:CAB14382" /db_xref="GOA:P54513" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG11703" /db_xref="UniProtKB/Swiss-Prot:P54513" /translation="MYIDGVFSGGGVKGIALAGAYEVLEEKGFRFKRVAGTSAGAIIA AFIASGYTSKEIHALIEEVDGEKLLDQRYSFLPLKMLQWVSIYWRLGLYKGDTIEKWI ADLLRAKGIRVFGDLQKGSLRLIASDLTNGTMIVLPDDLARYGLNPDMFPVARAVRMS CSIPYFFEPIKLKTDTGTATVVDGGVLSNFPIWLFSKERKRPVIGVTLAPRERERPKK NIRNAFELFGALFETMKDAHDARHIASRYEQNIIFLPVDDVMATDFHLTQQKKLALIE LGKRRTELFLKQWTY*" /label="yqhO CDS" gene complement(2129492..2130367) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /label="yqhO gene" promotor_-10 complement(2130394..2130412) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2130411) /Source="Nicolas_upshifts" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2130428..2130433) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2130493..2130921) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (hydrogen peroxide sensing, allosterically regulated by Mn2+)" /protein_id="NP_390332.2" /db_xref="EnsemblGenomes-Gn:BSU24520" /db_xref="EnsemblGenomes-Tr:CAB14383" /db_xref="GOA:P54512" /db_xref="InterPro:IPR001367" /db_xref="InterPro:IPR022687" /db_xref="InterPro:IPR022689" /db_xref="InterPro:IPR022897" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036421" /db_xref="PDB:1ON1" /db_xref="PDB:1ON2" /db_xref="PDB:2EV0" /db_xref="PDB:2EV5" /db_xref="PDB:2EV6" /db_xref="PDB:2F5C" /db_xref="PDB:2F5D" /db_xref="PDB:2F5E" /db_xref="PDB:2F5F" /db_xref="PDB:2HYF" /db_xref="PDB:2HYG" /db_xref="PDB:3R60" /db_xref="PDB:3R61" /db_xref="PDB:4HV5" /db_xref="PDB:4HV6" /db_xref="PDB:4HX4" /db_xref="PDB:4HX7" /db_xref="PDB:4HX8" /db_xref="SubtiList:BG11702" /db_xref="UniProtKB/Swiss-Prot:P54512" /translation="MTTPSMEDYIEQIYMLIEEKGYARVSDIAEALAVHPSSVTKMVQ KLDKDEYLIYEKYRGLVLTSKGKKIGKRLVYRHELLEQFLRIIGVDEEKIYNDVEGIE HHLSWNSIDRIGDLVQYFEEDDARKKDLKSIQKKTEHHNQ*" /label="mntR CDS" gene complement(2130493..2130921) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /label="mntR gene" downshifts complement(2130520) /Source="Nicolas_upshifts" /id="D1273" /incds=0 /nref=322 /ntot=333 /MaxReadThrough="2.568" /MaxDrop="7.28707" /score="15.888362" /energy="-12" /TU="NA" /idTUdmin="U1908" /TUdmin=6 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2130956..2130975) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2130964) /Source="Nicolas_upshifts" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2130991..2130995) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2131021..2131857) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /EC_number="2.3.1.181" /function="3: Fatty acid and phospholipid metabolism" /experiment="publication(s) with functional evidences, PMID:20882995, 21338420, 21338421, 23960015" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20882995, 21338420, 21338421, 23960015; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein octanoyltransferase" /protein_id="NP_390333.1" /db_xref="EnsemblGenomes-Gn:BSU24530" /db_xref="EnsemblGenomes-Tr:CAB14384" /db_xref="GOA:P54511" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024898" /db_xref="SubtiList:BG11701" /db_xref="UniProtKB/Swiss-Prot:P54511" /translation="MQKETWRFIDSGNASPAFNMALDEALLYWHSEKKIPPVIRFYGW NPATLSVGYFQNIKKEINFEAVHKYNLGFVRRPTGGRGVLHDQELTYSVIVSEEHPEM PATVTEAYRVISEGILQGFRNLGLDAYFAIPRTEKEKESLKNPRSSVCFDAPSWYELV VEGRKVAGSAQTRQKGVILQHGSILLDLDEDKLFDLFLYPSERVRERMQRNFKNKAVA INELIEKRVTMDEARKAFKEGFETGLNIHLEPYELSQEELDFVHHLAETKYASDEWNY KR*" /label="lipM CDS" gene complement(2131021..2131857) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /label="lipM gene" promotor_-10 complement(2131881..2131900) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2131892) /Source="Nicolas_upshifts" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2131894..2132438) /Source="Nicolas_S_feature" /locus_tag="new_2544841_2545385_c" /HighExp="Lbstat, LPhT, HiOs, M0t90, S1, M40t90, Sw, S0, B36, BC" /AntisenseName="yqhL" /AntisenseCor="-0.136624541005539" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S920" promotor_-35 complement(2131914..2131921) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2131938..2131943 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2131957..2131976 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2131957 /Source="Nicolas_upshifts" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="upshifts" S_feature 2131968..2132047 /Source="Nicolas_S_feature" /locus_tag="new_2544915_2544994" /HighExp="dia15, H2O2, dia5, Diami, MG-0.2, G180, UNK1, LBGexp, Heat, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S921" CDS 2132048..2132428 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11092948; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390334.2" /db_xref="EnsemblGenomes-Gn:BSU24540" /db_xref="EnsemblGenomes-Tr:CAB14385" /db_xref="GOA:P54510" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11700" /db_xref="UniProtKB/Swiss-Prot:P54510" /translation="MSNMIVLIIFAAFIIYMIASYVYQQRIMKTLTEEEFRAGYRKAQ LIDVREPNEFEGGHILGARNIPLSQLKQRKNEIRTDKPVYLYCQNSVRSGRAAQTLRK NGCTEIYNLKGGFKKWGGKIKAKK*" /label="yqhL CDS" gene 2132048..2132428 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /label="yqhL gene" downshifts 2132364 /Source="Nicolas_upshifts" /id="D1274" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17088" /MaxDrop="3.92673" /score="27.1863605" /energy="-12" /TU="U1909" /idTUdmin="U1909" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2132408 /Source="Nicolas_upshifts" /id="D1275" /incds=0 /nref=213 /ntot=249 /MaxReadThrough="2.26861" /MaxDrop="6.03848" /score="27.1863605" /energy="-12" /TU="NA" /idTUdmin="U1909" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2132463..2133929) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8181752, 20011599, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8181752, 20011599, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 2) (glycine cleavage system protein P)" /protein_id="NP_390335.1" /db_xref="EnsemblGenomes-Gn:BSU24550" /db_xref="EnsemblGenomes-Tr:CAB14386" /db_xref="GOA:P54377" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023012" /db_xref="SubtiList:BG11511" /db_xref="UniProtKB/Swiss-Prot:P54377" /translation="MSNQDQALIFELSREGRIGYSLPELDVPEIELGDLLSDTYIRDE DAALPEVSELDIMRHYTALSKRNHGVDSGFYPLGSCTMKYNPKINEKIARIPGFAAIH PLQDEDTVQGALELLYDLSKHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGD FKRTKVIVPDSAHGTNPASATVAGFETVTVKSNEKGLVDLEDLKRAVNEETAALMLTN PNTLGLFEEQITEMAEIVHQAGGKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFT GPHGGGGPGSGPVGVKQDLIPYLPKPVLVKKEGRFTFDYDRPHAIGRVKPYYGNFGIN VRAYTYIRSMGPDGLKAVTENAVLNANYMMRKLAPYYDLPFDRHCKHEFVLSGKRQKK LGVRTLDIAKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDAFIDAMIQIAKE AEENPELVQEAPHTTIVKRMDETKAARHPVLRYEAEER*" /label="gcvPB CDS" gene complement(2132463..2133929) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /label="gcvPB gene" downshifts complement(2132483) /Source="Nicolas_upshifts" /id="D1276" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="3.45831" /MaxDrop="4.3142" /score="0.884126414" /energy="-12" /TU="U1911" /idTUdmin="U1911" /TUdmin="-1517" /isTUend="FALSE" /label="downshifts" CDS complement(2133922..2135268) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8181752, 20011599, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 1) (glycine cleavage system protein P)" /protein_id="NP_390336.2" /db_xref="EnsemblGenomes-Gn:BSU24560" /db_xref="EnsemblGenomes-Tr:CAB14387" /db_xref="GOA:P54376" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023010" /db_xref="SubtiList:BG11510" /db_xref="UniProtKB/Swiss-Prot:P54376" /translation="MKHRYLPATEKDKQEMLATIGVSSIDDLFADIPENVKYKKEHQI KKAKSETELTRELTKLASKNRDTVQYASFLGAGVYDHYQPVIVDHVISRSEFYTAYTP YQPEISQGELQAIFEFQTMICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVV SKTVHPESREVLKTYAKGQYIDVVEVPAADGVTDLDALRQTVCENTAAVIVQYPNFFG RIEPLKDIEPIAHQGKSMFIVSANPLALGLLTPPGKFQSDIVVGDAQPFGIPSAYGGP HCGFFAVTKKLMRKVPGRLVGQTEDENGKRGFVLTLQAREQHIRRDKATSNICSNQAL NALAASVAMTALGKNGVKDIARQNLLKANYAKQEAKKAGLTVMFDGPMFNEFVIKLDE PVRAVNKRLLAKGMIGGYDLGLTYPELDCHMLIAVTELRTKEEIDALIQELGDRHE*" /label="gcvPA CDS" gene complement(2133922..2135268) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /label="gcvPA gene" CDS complement(2135298..2136386) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /EC_number="2.1.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8219277, 15472076, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8219277, 15472076, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminomethyltransferase (glycine cleavage system protein T)" /protein_id="NP_390337.2" /db_xref="EnsemblGenomes-Gn:BSU24570" /db_xref="EnsemblGenomes-Tr:CAB14388" /db_xref="GOA:P54378" /db_xref="InterPro:IPR006222" /db_xref="InterPro:IPR006223" /db_xref="InterPro:IPR013977" /db_xref="InterPro:IPR022903" /db_xref="InterPro:IPR028896" /db_xref="InterPro:IPR029043" /db_xref="PDB:1YX2" /db_xref="SubtiList:BG11509" /db_xref="UniProtKB/Swiss-Prot:P54378" /translation="MLKRTPLFDLYKEYGGKTIDFGGWELPVQFSSIKKEHEAVRTAA GLFDVSHMGEVEVSGNDSLSFLQRLMTNDVSALTPGRAQYTAMCYPDGGTVDDLLIYQ KGENRYLLVINASNIDKDLAWMKEHAAGDVQIDNQSDQIALLAVQGPKAEAILKNLTD ADVSALKPFAFIDEADISGRKALISRTGYTGEDGYEIYCRSDDAMHIWKKIIDAGDAY GLIPCGLGARDTLRFEAKLPLYGQELTRDITPIEAGIGFAVKHKKESDFFGKSVLSEQ KENGAKRKLVGLEMIEKGIPRHGYEVFQNGKSVGKVTTGTQSPTLGKNVGLALIDSET SEIGTVVDVEIRKKLVKAKVVKTPFYKR*" /label="gcvT CDS" gene complement(2135298..2136386) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /label="gcvT gene" misc_RNA complement(2136460..2136659) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /product="dual aptamer glycine riboswitch" /experiment="publication(s) with functional evidences, PMID:15472076, 21439473, 23249744, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15472076, 21439473, 23249744, 23721735, 29089431; Product type n: RNA" /label="swgA RNA" gene complement(2136460..2136659) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /label="swgA gene" downshifts complement(2136510) /Source="Nicolas_upshifts" /id="D1277" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="6.79606" /MaxDrop="3.0322" /score="21.5485037" /energy="-20.2" /TU="U1911" /idTUdmin="U1915" /TUdmin=3630 /isTUend="FALSE" /label="downshifts" S_feature complement(2136660..2136730) /Source="Nicolas_S_feature" /locus_tag="new_2549607_2549677_c" /HighExp="B60, S8, S6, B36, S7, M9-stat, Sw, T3.0H, HiOs, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S922" promotor_-35 2136663..2136668 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2136684..2136702 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2136688 /Source="Nicolas_upshifts" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2136698..2136827 /Source="Nicolas_S_feature" /locus_tag="new_2549645_2549774" /HighExp="S4, S8, S7, S3, S5, S6, LoTm, T5.0H, T4.0H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.83" /TUlongSig="NA" /TUlongPSig="NA" /label="S923" promotor_-10 complement(2136716..2136735) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-10" upshifts complement(2136730) /Source="Nicolas_upshifts" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="upshifts" promotor_-35 complement(2136749..2136756) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-35" CDS 2136828..2138501 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /EC_number="3.6.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA polymerase-associated helicase protein" /protein_id="NP_390338.1" /db_xref="EnsemblGenomes-Gn:BSU24580" /db_xref="EnsemblGenomes-Tr:CAB14389" /db_xref="GOA:P54509" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11699" /db_xref="UniProtKB/Swiss-Prot:P54509" /translation="MNTEMIYDAKWPEEFAERLKNDGPWANWELYKLSAEIQKTLAIP EFEGLRAPLYLPSFTPLPHQLEVAQKVVEKMNGKAILADEVGLGKTVEAGLILKEYMI RGLAKKILILVPASLVSQWVKELQEKFLIPAVEQKKSYVWEQCDIVVSSIDTAKRSPH REIVLSIPYDLVIIDEAHKLKNSKTKNYEFVRNLVKKYCLLLTATPIQNRIEEIFNLV SLLKPGHLGSQNHFQEEFAKKKSSLEAHEHLKDLVNKVMIRNRRHDTGLNWKQRHVET VPIQFSPSEQALYDEISRLKDSINKPASMFSIMTLQRECCSSREAVYMTLKKMLDQKE KQAPAIDEDTISVLIDRINQVTQNSKALQVVDLIKKIDDKVIIFTEYRATQIYLQWFL QQNGISSVPFRGGFKRGKKDWMKDLFRGKIQVLIATEAGGEGINLQFCNHMINYDLPW NPMRLEQRIGRIHRLGQERDVHIYNMATKHTVEEHILKLLYEKIHLFEKVVGELDDIL TKIQVNNFEEHLHDILYHSATEEEMKIKMDNLTSFLSYKKQLPAEKRGS*" /label="yqhH CDS" gene 2136828..2138501 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /label="yqhH gene" CDS 2138522..2139316 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390339.1" /db_xref="EnsemblGenomes-Gn:BSU24590" /db_xref="EnsemblGenomes-Tr:CAB14390" /db_xref="InterPro:IPR024562" /db_xref="SubtiList:BG11698" /db_xref="UniProtKB/Swiss-Prot:P54508" /translation="MRQQEVHDFLLRFFQANSCQIVDQGLGYMTVQLTVEMDKQIMNR PFYWHWREKTGGDPNPMKITFITDKENAPKDLDGEFIYFGAPRLFQIFKAVKQNGRFT RMYEKIESAGAKVPLQPWLGINVTISYQSDMKKDKLLSLGLHLVSGTIIEDFQSKLTQ FSLTSQICDYCFTISPMIKPESGLKRMENYISKSAMQEPSDWAEQAVNRWKNDMTLLD KFYEHIEEKPEEYHLEKQALKTLYQPKISVEIENGGLFYLQNNISS*" /label="yqhG CDS" gene 2138522..2139316 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /label="yqhG gene" misc_feature 2138852..2138853 /Source="Nicolas_upshift_promotors" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2138858 /Source="Nicolas_upshifts" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="upshifts" promotor_-35 2139340..2139343 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2139359..2139378 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2139360..2139498 /Source="Nicolas_S_feature" /locus_tag="new_2552307_2552445" /HighExp="LoTm, S4, S5, T5.0H, M9-stat, S3, B60, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.843, 0.83" /TUlongSig="SigA" /TUlongPSig="0.541" /label="S924" upshifts 2139360 /Source="Nicolas_upshifts" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2139499..2139672 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antagonist of SinR" /protein_id="NP_390340.1" /db_xref="EnsemblGenomes-Gn:BSU24600" /db_xref="EnsemblGenomes-Tr:CAB14391" /db_xref="GOA:P23308" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="SubtiList:BG10753" /db_xref="UniProtKB/Swiss-Prot:P23308" /translation="MKNAKQEHFELDQEWVELMVEAKEANISPEEIRKYLLLNKKSAH PGPAARSHTVNPF*" /label="sinI CDS" gene 2139499..2139672 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /label="sinI gene" promotor_-35 2139657..2139661 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2139674..2139693 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2139674 /Source="Nicolas_upshifts" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2139706..2140041 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator of biofilm formation" /protein_id="NP_390341.1" /db_xref="EnsemblGenomes-Gn:BSU24610" /db_xref="EnsemblGenomes-Tr:CAB14392" /db_xref="GOA:P06533" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="PDB:2YAL" /db_xref="PDB:3QQ6" /db_xref="PDB:3ZKC" /db_xref="SubtiList:BG10754" /db_xref="UniProtKB/Swiss-Prot:P06533" /translation="MIGQRIKQYRKEKGYSLSELAEKAGVAKSYLSSIERNLQTNPSI QFLEKVSAVLDVSVHTLLDEKHETEYDGQLDSEWEKLVRDAMTSGVSKKQFREFLDYQ KWRKSQKEE*" /label="sinR CDS" gene 2139706..2140041 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /label="sinR gene" downshifts 2140018 /Source="Nicolas_upshifts" /id="D1278" /incds=0 /nref=21 /ntot=181 /MaxReadThrough="4.7611" /MaxDrop="6.41889" /score="2.30357781" /energy="-20" /TU="U1913,U1914" /idTUdmin="U1910" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts 2140108 /Source="Nicolas_upshifts" /id="D1279" /incds=0 /nref=1 /ntot=85 /MaxReadThrough="2.4376" /MaxDrop="4.25363" /score="58.1462301" /energy="-26.8" /TU="NA" /idTUdmin="U1913" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts complement(2140140) /Source="Nicolas_upshifts" /id="D1280" /incds=0 /nref=144 /ntot=227 /MaxReadThrough="4.33009" /MaxDrop="8.70948" /score="10.0483516" /energy="-20" /TU="NA" /idTUdmin="U1915" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(2140157,2140164) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs27" N_region 2140158..2140163 /note="SacI site (GAGCTC)" /created_by="User" /label="IIG_Bs27" promotor_-35 2140233..2140239 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2140240 /Source="Nicolas_upshifts" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2140253..2140264 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2140283..2140609 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390345.1" /db_xref="EnsemblGenomes-Gn:BSU24650" /db_xref="EnsemblGenomes-Tr:CAB14396" /db_xref="InterPro:IPR024987" /db_xref="PDB:2LYX" /db_xref="SubtiList:BG13773" /db_xref="UniProtKB/Swiss-Prot:O32019" /translation="MMIKQCVICLSLLVFGTTAAHAEETPLVTARHMSKWEEIAVKEA KKRYPLAQVLFKQKVWDRKRKDEAVKQYHLTLREGSKEFGVFVTISFDPYSQKVNKIA ILEEYQ*" /label="yqzG CDS" gene 2140283..2140609 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /label="yqzG gene" S_feature complement(2140426..2140650) /Source="Nicolas_S_feature" /locus_tag="new_2555662_2555886_c" /HighExp="GM 150, G/S, C30, T-4.40H, S8, T-3.40H, Pyr, S7, S2, C90" /AntisenseName="yqzG" /AntisenseCor="0.536702817178903" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.549, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S925" downshifts complement(2140469) /Source="Nicolas_upshifts" /id="D1281" /incds=1 /nref=92 /ntot=160 /MaxReadThrough="2.23218" /MaxDrop="5.56661" /score="31.27773" /energy="-10.2" /TU="NA" /idTUdmin="U1918" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2140591 /Source="Nicolas_upshifts" /id="D1282" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="2.14107" /MaxDrop="4.98052" /score="-9.62570043" /energy="-15.1" /TU="NA" /idTUdmin="U1917" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2140651..2140830) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="factor involved in sporulation" /protein_id="NP_390346.2" /db_xref="EnsemblGenomes-Gn:BSU24660" /db_xref="EnsemblGenomes-Tr:CAB14397" /db_xref="InterPro:IPR025622" /db_xref="SubtiList:BG13771" /db_xref="UniProtKB/Swiss-Prot:O32020" /translation="MKTNDYVKYMTQQFVKYIDTPRDERKERKEVRKETKTPVSQQWF GILPYGFRLWLKRKK*" /label="spoIIT CDS" gene complement(2140651..2140830) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /label="spoIIT gene" promotor_-10 complement(2140849..2140867) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2140864) /Source="Nicolas_upshifts" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2140882..2140888) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2140901..2141275) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406, 24164455; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390347.1" /db_xref="EnsemblGenomes-Gn:BSU24670" /db_xref="EnsemblGenomes-Tr:CAB14398" /db_xref="GOA:P25959" /db_xref="InterPro:IPR020372" /db_xref="SubtiList:BG10489" /db_xref="UniProtKB/Swiss-Prot:P25959" /translation="MYRTRGFIYPAVLFVSALVLLIVNFVAAQYISRCMFEKETKELY IGENLLQNGVLLSIRHVLEERKGQEGTQQFLYGRVSYYIHDTSIKEQKEINLRVSTDS GTERTAQIVFDQKQKKLLRWTE*" /label="comGG CDS" gene complement(2140901..2141275) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /label="comGG gene" CDS complement(2141276..2141659) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390348.1" /db_xref="EnsemblGenomes-Gn:BSU24680" /db_xref="EnsemblGenomes-Tr:CAB14399" /db_xref="GOA:P25958" /db_xref="InterPro:IPR016977" /db_xref="SubtiList:BG10488" /db_xref="UniProtKB/Swiss-Prot:P25958" /translation="MLISGSLAAIIHLFLSRQQEHDGFTQQEWMISIEQMMNECKESQ AVKTAEHGSVLICTNLSGQDIRFDIYHSMIRKRVDGKGHVPILDHITAMKADIENGVV LLKIESEDQKVYQTAFPVYSYLGGG*" /label="comGF CDS" gene complement(2141276..2141659) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /label="comGF gene" CDS complement(2141685..2142032) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /function="16.11: Scavenge (Catabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7783624, 9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390349.1" /db_xref="EnsemblGenomes-Gn:BSU24690" /db_xref="EnsemblGenomes-Tr:CAB14400" /db_xref="GOA:P25957" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR020488" /db_xref="SubtiList:BG10487" /db_xref="UniProtKB/Swiss-Prot:P25957" /translation="MWRENKGFSTIETMSALSLWLFVLLTVVPLWDKLMADEKMAESR EIGYQMMNESISKYVMSGEGAASKTITKNNHIYAMKWEEEGEYQNVCIKAAAYKEKSF CLSILQTEWLHAS*" /label="comGE CDS" gene complement(2141685..2142032) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /label="comGE gene" CDS complement(2142016..2142447) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane component of the DNA transport pilin platform" /protein_id="NP_390350.1" /db_xref="EnsemblGenomes-Gn:BSU24700" /db_xref="EnsemblGenomes-Tr:CAB14401" /db_xref="GOA:P25956" /db_xref="InterPro:IPR002416" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016785" /db_xref="SubtiList:BG10486" /db_xref="UniProtKB/Swiss-Prot:P25956" /translation="MNIKLNEEKGFTLLESLLVLSLASILLVAVFTTLPPAYDNTAVR QAASQLKNDIMLTQQTAISRQQRTKILFHKKEYQLVIGDTVIERPYATGLSIELLTLK DRLEFNEKGHPNAGGKIRVKGHAVYDITVYLGSGRVNVERK*" /label="comGD CDS" gene complement(2142016..2142447) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /label="comGD gene" CDS complement(2142437..2142733) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="pilin-like component of the DNA transport membrane pilin platform" /protein_id="NP_390351.1" /db_xref="EnsemblGenomes-Gn:BSU24710" /db_xref="EnsemblGenomes-Tr:CAB14402" /db_xref="GOA:P25955" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016940" /db_xref="SubtiList:BG10485" /db_xref="UniProtKB/Swiss-Prot:P25955" /translation="MNEKGFTLVEMLIVLFIISILLLITIPNVTKHNQTIQKKGCEGL QNMVKAQMTAFELDHEGQTPSLADLQSEGYVKKDAVCPNGKRIIITGGEVKVEH*" /label="comGC CDS" gene complement(2142437..2142733) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /label="comGC gene" CDS complement(2142747..2143718) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 15968048, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 15968048, 16850406, 24164455; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane pilin platform component of the DNA transport machinery" /protein_id="NP_390352.1" /db_xref="EnsemblGenomes-Gn:BSU24720" /db_xref="EnsemblGenomes-Tr:CAB14403" /db_xref="GOA:P25954" /db_xref="InterPro:IPR001992" /db_xref="InterPro:IPR018076" /db_xref="SubtiList:BG10484" /db_xref="UniProtKB/Swiss-Prot:P25954" /translation="MTAGGYTLLDGLRLMELQMNKRQAADLTDSVTCLREGAPFYQVL KSLSFHKEAVGICYFAETHGELPASMIQSGELLERKIAQADQLKRVLRYPLFLIFTVA VMFYMLQSIIIPQFSGIYQSMNMETSRSTDMLFAFFQHIDLVIILLVLFTAGIGIYYW LVFKKKSPARQMLICIRIPLVGKLVKLFNSYFFSLQLSSLLKSGLSIYDSLNAFKHQT FLPFYRCEAEQLIERLKAGESIESAICGSLFYETDLSKVISHGQLSGRLDRELFTYSQ FILQRLEHKAQKWTGILQPMIYGFVAAMILLVYLSMLVPMYQMMNQM*" /label="comGB CDS" gene complement(2142747..2143718) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /label="comGB gene" CDS complement(2143771..2144841) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane associated ATPase of the pilin platformfor DNA competence" /protein_id="NP_390353.1" /db_xref="EnsemblGenomes-Gn:BSU24730" /db_xref="EnsemblGenomes-Tr:CAB14404" /db_xref="GOA:P25953" /db_xref="InterPro:IPR001482" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10483" /db_xref="UniProtKB/Swiss-Prot:P25953" /translation="MDSIEKVSKNLIEEAYLTKASDIHIVPRERDAIIHFRVDHALLK KRDMKKEECVRLISHFKFLSAMDIGERRKPQNGSLTLKLKEGNVHLRMSTLPTINEES LVIRVMPQYNIPSIDKLSLFPKTGATLLSFLKHSHGMLIFTGPTGSGKTTTLYSLVQY AKKHFNRNIVTLEDPVETRDEDVLQVQVNEKAGVTYSAGLKAILRHDPDMIILGEIRD AETAEIAVRAAMTGHLVLTSLHTRDAKGAIYRLLEFGINMNEIEQTVIAIAAQRLVDL ACPFCENGCSSVYCRQSRNTRRASVYELLYGKNLQQCIQEAKGNHANYQYQTLRQIIR KGIALGYLTTNNYDRWVYHEKD*" /label="comGA CDS" gene complement(2143771..2144841) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /label="comGA gene" promotor_-10 complement(2144859..2144878) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2144875) /Source="Nicolas_upshifts" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2144892..2144899) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2145024..2145252) /Source="Nicolas_S_feature" /locus_tag="new_2560260_2560488_c" /HighExp="Etha, Salt, Sw, Gly, LPhT, B36, Heat, B60, LoTm, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37350499999999998" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S926" downshifts complement(2145065) /Source="Nicolas_upshifts" /id="D1283" /incds=0 /nref=16 /ntot=42 /MaxReadThrough="0.95925" /MaxDrop="5.92871" /score="30.7083619" /energy="-13" /TU="NA" /idTUdmin="U1920" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2145253..2146206) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15856219, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15856219, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="CorA-type divalent ion transporter" /protein_id="NP_390354.1" /db_xref="EnsemblGenomes-Gn:BSU24740" /db_xref="EnsemblGenomes-Tr:CAB14405" /db_xref="GOA:P40948" /db_xref="InterPro:IPR002523" /db_xref="SubtiList:BG11075" /db_xref="UniProtKB/Swiss-Prot:P40948" /translation="MKAHTGKDWFWYQMGPQERSKARDLIHFSHWPQCEKWFENNHHV NFLRVDTTETENEAVFGSIVYDQGLGEEKDHTVFHFYITRQYFFTINFDFSILREIKG KEVVRQMERADNAIEGFLILLGELMNAYLIGVDEFEVKLRKLRWQIKDDNSKSILNRV HLLRHELMIWKNLILSAKKIEMALKETFLPQNEGKKDYQRTQLKIDRGFTYISEFEGE LNNLLHSEEVITSHRGNEIVKALTIFTTLFTPITALGALWGMNFSVMPELNWKYGYLF SLLLIVTSTVLIYLYLRKKGWTGDMLQERKKKKKPRKRRTL*" /label="yqxL CDS" gene complement(2145253..2146206) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /label="yqxL gene" promotor_-10 complement(2146230..2146249) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2146251) /Source="Nicolas_upshifts" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2146263..2146269) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2146289..2146295 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2146310..2146328 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2146328 /Source="Nicolas_upshifts" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="upshifts" CDS 2146349..2147677 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane associated enzyme" /protein_id="NP_390355.1" /db_xref="EnsemblGenomes-Gn:BSU24750" /db_xref="EnsemblGenomes-Tr:CAB14406" /db_xref="GOA:P54505" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11695" /db_xref="UniProtKB/Swiss-Prot:P54505" /translation="MPSLEKAVVLEFINLLAVAILILLTGFFVAVEFSIVKVRRSKID QLVAKGKKGAKAAKHVITHLDEYLSACQLGITVAALGLGWLGEPTVQTLLRPLFHKAG LNESLTHLLSLVIAFLVVTYLNVVIGELAPKSFAIQKAESITLLFAKPLIWFYKIMFP FIWLLNHSARLITGVFGLKPASEHELAYTEEELRVLLAESYKSGEIRKSELKYMNNIF TFDKRMAKEIMVPRNEMVSLSLDEDSISNLQETVKQTKYTRYPVVREDKDNVIGVINM KEVLFSMLTKDFSIKKHQIEPFVQPVIHVIETIPIYKLLLKMQKERTHMAILIDEYGG TSGLVTVEDIIEEIVGEIRDEFDADEVPHIRELGKDHYLLNAKLLISDVNSLLGTDLS EAEVDTLGGWFLTQNIDAEPESAIEYDGYSFKVKDINSHHILFIEVKKAE*" /label="yqhB CDS" gene 2146349..2147677 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /label="yqhB gene" S_feature 2147678..2148652 /Source="Nicolas_S_feature" /locus_tag="new_2562914_2563888" /HighExp="Sw, Salt, Etha, LPhT, M9-stat, S8, BC, S6, BT, Gly" /AntisenseName="rsbRD" /AntisenseCor="0.58358076577781004" /AntisenseRegPval="-25.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S927" CDS complement(2147730..2148566) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11157946, 15312768, 15583165, 16963570, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157946, 15312768, 15583165, 16963570, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_390356.2" /db_xref="EnsemblGenomes-Gn:BSU24760" /db_xref="EnsemblGenomes-Tr:CAB14407" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR025751" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11694" /db_xref="UniProtKB/Swiss-Prot:P54504" /translation="MIALDQHLTEHKKDITQQWLEVCTSNGSWLYSAKDQQKLEQKLK DQHELLVTIVAKSLRKEDVEDELNRWSLQCARDRAVHEVTVTQSVGQFNTFRHIMFEW IHKFSEASSQDISIQEFYEWSRILNQNIDEIIEVFTEEYHQVTMIQLNAQKEMINELS APIMPITDGIGILPLVGEIDTHRARTILESVLEQCSALKLSYLFLDISGVPIVDTMVA YQIFKVIDSTKLLGIETIISGIRPEIAQTVVKLGLDFSNVKTEQSLAKALANKGFKIK EC*" /label="rsbRD CDS" gene complement(2147730..2148566) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /label="rsbRD gene" S_feature complement(2148567..2148751) /Source="Nicolas_S_feature" /locus_tag="new_2563803_2563987_c" /HighExp="Etha, LoTm, Salt, Heat, Gly, M9-stat, B60, S8, S0, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147982" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S928" tRNA 2148653..2148723 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln (UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Gln1 tRNA" gene 2148653..2148723 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /label="trnSL-Gln1 gene" CDS complement(2148790..2149170) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:18643936, 22812682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18643936, 22812682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of stress" /protein_id="NP_390357.2" /db_xref="EnsemblGenomes-Gn:BSU24770" /db_xref="EnsemblGenomes-Tr:CAB14408" /db_xref="GOA:P54503" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11693" /db_xref="UniProtKB/Swiss-Prot:P54503" /translation="MEQQLTFYSYPSCTSCRKTKHWLKAHQIEFNERHLFRETPTREE LKYILSLTTEGIDEILATRSQTFKNLNLNIEEMTVNEVLELLIEKPKLLRRPILVDNK KLVIGYNPGELLKLSKKKTVHQSA*" /label="mgsR CDS" gene complement(2148790..2149170) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /label="mgsR gene" downshifts complement(2148796) /Source="Nicolas_upshifts" /id="D1284" /incds=0 /nref=9 /ntot=174 /MaxReadThrough="6.12556" /MaxDrop="6.72616" /score="0.164931099" /energy="-19.7" /TU="U1922" /idTUdmin="U1925" /TUdmin=912 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2149199..2149217) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2149218) /Source="Nicolas_upshifts" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2149232..2149238) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2149257..2149262 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-35" promotor_-10 2149278..2149296 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-10" upshifts 2149287 /Source="Nicolas_upshifts" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="upshifts" promotor_-35 2149337..2149344 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-35" upshifts 2149359 /Source="Nicolas_upshifts" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="upshifts" promotor_-10 2149360..2149379 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-10" CDS 2149402..2149647 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390358.1" /db_xref="EnsemblGenomes-Gn:BSU24780" /db_xref="EnsemblGenomes-Tr:CAB14409" /db_xref="GOA:P54502" /db_xref="InterPro:IPR020254" /db_xref="SubtiList:BG11692" /db_xref="UniProtKB/Swiss-Prot:P54502" /translation="MNRMFRVLGFWTGIFAVMFYLGDMKDASLLFFGQTILFVFLSYL NLTERMYIYIFGAYLTIFFAGFTYYSIFIMVPGGGGH*" /label="yqgY CDS" gene 2149402..2149647 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /label="yqgY gene" downshifts 2149544 /Source="Nicolas_upshifts" /id="D1285" /incds=1 /nref=1 /ntot=86 /MaxReadThrough="6.68961" /MaxDrop="2.1025" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=176 /isTUend="FALSE" /label="downshifts" downshifts 2149633 /Source="Nicolas_upshifts" /id="D1286" /incds=0 /nref=98 /ntot=234 /MaxReadThrough="4.03872" /MaxDrop="5.76938" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=265 /isTUend="FALSE" /label="downshifts" S_feature 2149678..2150433 /Source="Nicolas_S_feature" /locus_tag="new_2564914_2565669" /HighExp="M9-stat, T0.30H, T1.30H, LoTm, T1.0H, B60, T2.0H, S5, S4, T2.30H" /AntisenseName="yqgX" /AntisenseCor="-0.68109878166952498" /AntisenseRegPval="-37.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S929" CDS complement(2149687..2150322) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20669241, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-binding hydrolase" /protein_id="NP_390359.1" /db_xref="EnsemblGenomes-Gn:BSU24790" /db_xref="EnsemblGenomes-Tr:CAB14410" /db_xref="GOA:P54501" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11691" /db_xref="UniProtKB/Swiss-Prot:P54501" /translation="MKWRRMPVGPIQANAYFLISDDQCLIFDPGGEGHKINQYIKEKG LTPLAILLTHAHFDHIGALDEVREKWDIPVYLHQNEKNWLADASLNGSGMLRGIEVTA KPADHLIEGDGELNIGPFHLETLFTPGHSPGSVSYYVKDADLVISGDVLFQGGIGRTD LIGGNQETLLTSIHEKLLTLPEHTLVLSGHGPETDVLTEQDQNPFLNGFSL*" /label="yqgX CDS" gene complement(2149687..2150322) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /label="yqgX gene" downshifts complement(2149712) /Source="Nicolas_upshifts" /id="D1287" /incds=0 /nref=154 /ntot=239 /MaxReadThrough="1.42757" /MaxDrop="5.15622" /score="-8.36666809" /energy="-13.7" /TU="NA" /idTUdmin="U1925" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2150344..2150363) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2150361) /Source="Nicolas_upshifts" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2150377..2150384) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2150401..2150408 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2150423..2150442 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2150435 /Source="Nicolas_upshifts" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2150455) /Source="Nicolas_upshifts" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2150457..2150471) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2150479..2150483) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2150479..2150652 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390360.1" /db_xref="EnsemblGenomes-Gn:BSU24800" /db_xref="EnsemblGenomes-Tr:CAB14411" /db_xref="GOA:P54500" /db_xref="InterPro:IPR024490" /db_xref="SubtiList:BG11690" /db_xref="UniProtKB/Swiss-Prot:P54500" /translation="MLLVVIFGLVALFALWGVLRSVRNKNILGFLLAGATLFVFGWFT VMTVINSGYPTAH*" /label="yqgW CDS" gene 2150479..2150652 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /label="yqgW gene" downshifts 2150640 /Source="Nicolas_upshifts" /id="D1288" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="3.92092" /MaxDrop="7.18555" /score="14.1643615" /energy="-12.4" /TU="U1926" /idTUdmin="U1924" /TUdmin=217 /isTUend="FALSE" /label="downshifts" CDS complement(2150684..2150998) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390361.2" /db_xref="EnsemblGenomes-Gn:BSU24810" /db_xref="EnsemblGenomes-Tr:CAB14412" /db_xref="GOA:P54499" /db_xref="InterPro:IPR002767" /db_xref="InterPro:IPR029756" /db_xref="SubtiList:BG11689" /db_xref="UniProtKB/Swiss-Prot:P54499" /translation="MAIADVTIIPIGTETPSVSAYVADVQKILEGYQAEGKIKYQLTP MNTLIEGELSDLFAVIQAIHEAPFQKGLHRVATNIRIDDRRDKKTTLESKIESVNKHL QP*" /label="yqgV CDS" gene complement(2150684..2150998) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /label="yqgV gene" S_feature 2150685..2151752 /Source="Nicolas_S_feature" /locus_tag="new_2565921_2566988" /HighExp="LoTm, M9-stat, C30, Cold, S8, S7, B60, Lbstat, G135, C90" /AntisenseName="yqgV" /AntisenseCor="-0.23995763414552801" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigEF" /TUlongPSig="1, 1" /label="S930" downshifts complement(2150698) /Source="Nicolas_upshifts" /id="D1289" /incds=0 /nref=247 /ntot=265 /MaxReadThrough="2.24429" /MaxDrop="6.85096" /score="0.185625845" /energy="-12.4" /TU="NA" /idTUdmin="U1928" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2151001..2152062) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390362.2" /db_xref="EnsemblGenomes-Gn:BSU24820" /db_xref="EnsemblGenomes-Tr:CAB14413" /db_xref="GOA:P54498" /db_xref="SubtiList:BG11688" /db_xref="UniProtKB/Swiss-Prot:P54498" /translation="MLMRSVCFILLAVLLFSLSACEPSHQQQKQASAAKDEKKDIIPL SAEKADGAEGWLNNSTILYTASNPTKTELFAYRIFTGKAKKLYQTDGQIVDVQINARE QMILLQITHSQKTAVVLLNAEGETLYEKDYETYELEAAWNQYDPYQMMVTEFNENWDF HTYQVNAKKDESFLSPVQVPFIHWTSKNTFDYVKEGRDDKTGPLYTFDTASKTEQKLE DNVLFFDSFHQMSFTVKSASGGKGTYQFKTPQSTSPVTAKWPLQAKYTSLAPMEYDYD EAGGLFYTFKQSGDAYKLAAINVASGETKDLVSLREMEPIQISPNGKYALYGFHFEQI ILLKSHETKQLIIDQKEME*" /label="yqgU CDS" gene complement(2151001..2152062) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /label="yqgU gene" CDS complement(2152124..2153254) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12765833, 24163346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative d,l-endopeptidase" /protein_id="NP_390363.1" /db_xref="EnsemblGenomes-Gn:BSU24830" /db_xref="EnsemblGenomes-Tr:CAB14414" /db_xref="GOA:P54497" /db_xref="InterPro:IPR000834" /db_xref="InterPro:IPR034274" /db_xref="SubtiList:BG11687" /db_xref="UniProtKB/Swiss-Prot:P54497" /translation="MMAFITVKPEIKNNLANVAKELKIDEELLKSANRSAQKHQLYCP GYVIEEHSGKELQTIQDIKRFLQPRQLKLSDSWIEQEKIYDDSAVEKEIKKIIDVFPF VSCREIGRSVLGRPIWELKAGGEHAVKKVHMNASFHANEWITTSVLLKWFKEYCMSLC CNSPFFGFSPIKLFNSTSLSLVPLVNPDGVDLVLNGSEVMGARRDELERLNEHRPNFN EWKANINGVDLNKQFPSLWEIEKYRKPTAPSYRDFPGISPLTEPESIAMYRLITENPP DRLLALHTQGEEIYWGYKGLEPEESAAVIKEFEELSGNIYKGVRDIDSYAGFRDWFIH HYFKEGYTVELGKGQNPLPFQQFSHIYNATSGILWRALFFHE*" /label="yqgT CDS" gene complement(2152124..2153254) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /label="yqgT gene" promotor_-10 complement(2153262..2153280) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2153294) /Source="Nicolas_upshifts" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2153296..2153301) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2153337..2155253) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647, 25666134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647, 25666134; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_390364.2" /db_xref="EnsemblGenomes-Gn:BSU24840" /db_xref="EnsemblGenomes-Tr:CAB14415" /db_xref="GOA:P54496" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG11686" /db_xref="UniProtKB/Swiss-Prot:P54496" /translation="MRKTFFSKISFMLIAILLMWLKTYAVYKTSFHIKIDNLTQEFIL FINPLSFLLLIFGLSLFLKGKNRNRYIIAMSCLVTFVLLANMVFYRFYNDFLTIPVLF QTSNMGDLGSSIGTLLEPTDLLLAVDIAVLIWLHIRQKAFQSDIPSTKNERAAYFLFV ASVYFFNLGLSEAERPQLLTRSFDREMLVKNISLFNFHIYDGVLQSKQSAQRALADSN SLTEIENYVTANAKDANKRLFGAAKGRNVILVSLESTQSFVINEKLNGEEITPFLNDF IKQSYNFNNVYHQTGQGKTSDSEFIVDNSLYPLGRGAVFFTNAGNQYMAAPEILKNSG YYSAVLHANNKSFWNRDLMYDSFGYDSFFDINSYDVTDENSVGWGLKDKEFFEQSSEL MKNLPQPFYSRLITLTNHFPFDLDEEDQLIDEYDSNSQTLNKYFPTVRYQDEALKRFI EKLKEDGLYDNSVIVLYGDHYGISENHNEAMGQFLGKEITPFEEVQLQKVPLVIHIPG ITDKKPQTIETVGGQIDIRPTLMNLLGIDTKDQIQFGNDLLSDEKLDFTVLRDGSFIT DQVVYTDGACYDKETGKPLEETKQCEAFADKAKQELSLSDEIIYGDLLRFYDQKRLDN SSKRKEKQMLDQAS*" /label="ltaSC CDS" gene complement(2153337..2155253) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /label="ltaSC gene" downshifts complement(2153364) /Source="Nicolas_upshifts" /id="D1290" /incds=0 /nref=5 /ntot=142 /MaxReadThrough="4.5611" /MaxDrop="3.8416" /score="15.4764643" /energy="-14.5" /TU="U1930,U1931" /idTUdmin="U1928" /TUdmin="-2667" /isTUend="FALSE" /label="downshifts" promotor_-35 2154369..2154375 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2154388..2155417 /Source="Nicolas_S_feature" /locus_tag="new_2569624_2570653" /HighExp="Etha, Gly, M9-stat, Salt, S8, LPhT, S7, Sw, HiTm, B60" /AntisenseName="yqgS" /AntisenseCor="-0.36996929809172002" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S931" upshifts 2154388 /Source="Nicolas_upshifts" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2154391..2154409 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(2155254..2155320) /Source="Nicolas_S_feature" /locus_tag="new_2570490_2570556_c" /HighExp="T-3.40H, BC, Sw, S5, Lbstat, T-5.40H, S4, ferm, C30, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S932" promotor_-10 complement(2155314..2155333) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2155320) /Source="Nicolas_upshifts" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2155348..2155355) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2155370..2156335) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /EC_number="2.7.1.59" /EC_number="2.7.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose kinase" /protein_id="NP_390365.2" /db_xref="EnsemblGenomes-Gn:BSU24850" /db_xref="EnsemblGenomes-Tr:CAB14416" /db_xref="GOA:P54495" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR004654" /db_xref="SubtiList:BG11685" /db_xref="UniProtKB/Swiss-Prot:P54495" /translation="MDEIWFAGIDLGGTTIKLAFINQYGEIQHKWEVPTDKTGDTITV TIAKTIDSKLDELQKPKHIIKYIGMGAPGPVDMAAGVVYETVNLGWKNYALKNHLETE TGIPAVIENDANIAALGEMWKGAGDGAKDVILVTLGTGVGGGIIANGEIVHGINGAGG EIGHICSIPEGGAPCNCGKTGCIETIASATGIVRIAKEKIANAKKTTRLKATEQLSAR DVFEAAGENDEIALEVVDYVAKHLGLVLGNLASSLNPSKIVLGGGVSRAGELLRSKVE KTFRKCAFPRAAQAADISIAALGNDAGVIGGAWIAKNEWLKHQNC*" /label="glcK CDS" gene complement(2155370..2156335) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /label="glcK gene" CDS complement(2156346..2156561) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /function="9.3: Transcription factors" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15050034, 20057058; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative single strand nucleic acid binding transcription factor" /protein_id="NP_390366.1" /db_xref="EnsemblGenomes-Gn:BSU24860" /db_xref="EnsemblGenomes-Tr:CAB14417" /db_xref="InterPro:IPR009256" /db_xref="InterPro:IPR023164" /db_xref="PDB:2NN4" /db_xref="SubtiList:BG11684" /db_xref="UniProtKB/Swiss-Prot:P54494" /translation="MNTFYDVQQLLKTFGHIVYFGDRELEIEFMLDELKELYMNHMIE KEQWARAAAVLRKELEQTKNGRDFYKG*" /label="yqgQ CDS" gene complement(2156346..2156561) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /label="yqgQ gene" S_feature complement(2156562..2156670) /Source="Nicolas_S_feature" /locus_tag="new_2571798_2571906_c" /HighExp="M0t90, Lbstat, M40t90, M40t45, Lbtran, Mt0, dia5, Diami, M0t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S933" CDS complement(2156671..2158194) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /EC_number="3.4.21.105" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15050034, 16355228, 23518036, 26858402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane endopeptidase" /protein_id="NP_390367.2" /db_xref="EnsemblGenomes-Gn:BSU24870" /db_xref="EnsemblGenomes-Tr:CAB14418" /db_xref="GOA:P54493" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG11683" /db_xref="UniProtKB/Swiss-Prot:P54493" /translation="MFLLEYTYWKIAAHLVNSGYGVIQAGESDEIWLEAPDKSSHDLV RLYKHDLDFRQEMVRDIEEQAERVERVRHQLGRRRMKLLNVFFSTEAPVDDWEEIAKK TFEKGTVSVEPAIVRGTMLRDDLQAVFPSFRTEDCSEEHASFENAQMARERFLSLVLK QEEQRKTEAAVFQNGKPTFTYLFIALQILMFFLLEINGGSTNTETLVAFGAKENSLIA QGEWWRLLTPIVLHIGIAHLAFNTLALWSVGTAVERMYGSGRFLLIYLAAGITGSIAS FVFSPYPSAGASGAIFGCLGALLYVALSNRKMFLRTIGTNIIVIIIINLGFGFAVSNI DNSGHIGGLIGGFFAAAALGLPKAGAFGKRLLSAVLLIALAVGFLYYGLHSPSHQESA LIQQASELYQEGKYEEVTELLNGEAAQKDASADLLKILAVSDIQIGEYDQAVSLLERA VKKEPKDHASYYNLALLYAEKNELAQAEKAIQTAVKLKPKEQRYKELQRQIENNKES* " /label="glpG CDS" gene complement(2156671..2158194) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /label="glpG gene" promotor_-10 complement(2158212..2158231) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2158225) /Source="Nicolas_upshifts" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2158246..2158253) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2158284..2158457) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390368.1" /db_xref="EnsemblGenomes-Gn:BSU24880" /db_xref="EnsemblGenomes-Tr:CAB14419" /db_xref="SubtiList:BG11682" /db_xref="UniProtKB/Swiss-Prot:P54492" /translation="MKKLLIYAIFAVSAVMFYQNRYRLMNTVLSQPGIRRSFIHLFLR IPFIRNKFIQQAF*" /label="yqgO CDS" gene complement(2158284..2158457) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /label="yqgO gene" downshifts complement(2158311) /Source="Nicolas_upshifts" /id="D1291" /incds=0 /nref=121 /ntot=211 /MaxReadThrough="2.93694" /MaxDrop="5.6047" /score="19.2452946" /energy="-8.9" /TU="NA" /idTUdmin="U1932" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2158473..2158484) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2158485) /Source="Nicolas_upshifts" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2158498..2158504) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2158524..2159087) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /EC_number="6.3.3.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17329806, 20952389, 22773193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-formyltetrahydrofolate cyclo-ligase" /protein_id="NP_390369.1" /db_xref="EnsemblGenomes-Gn:BSU24890" /db_xref="EnsemblGenomes-Tr:CAB14420" /db_xref="GOA:P54491" /db_xref="InterPro:IPR002698" /db_xref="PDB:1YDM" /db_xref="SubtiList:BG11681" /db_xref="UniProtKB/Swiss-Prot:P54491" /translation="MKSQLRKKTLEALSALSNEDILQKTERMYKYLFSLPEWQNAGTI AVTISRGLEIPTRPVIEQAWEEGKQVCIPKCHPDTKKMQFRTYQTDDQLETVYAGLLE PVIEKTKEVNPSQIDLMIVPGVCFDVNGFRVGFGGGYYDRYLSEYEGKTVSLLLECQL FAHVPRLPHDIPVHKLITEDRIISCFS*" /label="folN CDS" gene complement(2158524..2159087) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /label="folN gene" S_feature complement(2159088..2159171) /Source="Nicolas_S_feature" /locus_tag="new_2574324_2574407_c" /HighExp="Cold, G180, LBGexp, LBGtran, G135, HPh, LPh, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S934" CDS complement(2159172..2159321) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12904577, 19648245, 22720735, 23002217, 27561249; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_570908.2" /db_xref="EnsemblGenomes-Gn:BSU24900" /db_xref="EnsemblGenomes-Tr:CAE01461" /db_xref="GOA:P56849" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG14180" /db_xref="UniProtKB/Swiss-Prot:P56849" /translation="MRVNITLACTECGERNYISKKNKRNNPDRVEFKKYCPRDKKSTL HRETK*" /label="rpmGA CDS" gene complement(2159172..2159321) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /label="rpmGA gene" downshifts complement(2159218) /Source="Nicolas_upshifts" /id="D1292" /incds=0 /nref=154 /ntot=253 /MaxReadThrough="5.3064" /MaxDrop="4.5881" /score="34.7393253" /energy="-15.3" /TU="U1933" /idTUdmin="U1932" /TUdmin="-907" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2159358..2159377) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2159368) /Source="Nicolas_upshifts" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2159393..2159396) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2159405..2160484) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_390370.2" /db_xref="EnsemblGenomes-Gn:BSU24910" /db_xref="EnsemblGenomes-Tr:CAB14421" /db_xref="GOA:P54490" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11680" /db_xref="UniProtKB/Swiss-Prot:P54490" /translation="MNILMLSPEHPDEPKSGLGVHLNRLISYLNPHINITVFTPSGQL FSYAKFEDYIADANFTMVRHVLSHNKRFDLIHAHDDTTAPAAQYLKQRLGLPLAATIH GLESERKKVCREAPHPYRLMTERLLIESADALIVLSTFMKRSLDKAAHKKITVIPSPA SMEEEKGKIPRSMNRRFLFSYGRFVPEKGLSQLLKVFAILKQRQPDLYLVLAGEGPSL SCYEKLAAAYNLKDRVMFLPFLNRKDIRTLLSHCEMAVFPSSYEPFGLAAQESMEQGV LTVVSQSGGFCDYAVHDKTAIIADFTLVQEAADLLDSFLKDREKARRIKEAGRQQVFK LHHPRLIMSSYLQLYERIFNNSAIH*" /label="yqgM CDS" gene complement(2159405..2160484) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /label="yqgM gene" CDS complement(2160481..2160951) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390371.1" /db_xref="EnsemblGenomes-Gn:BSU24920" /db_xref="EnsemblGenomes-Tr:CAB14422" /db_xref="SubtiList:BG11679" /db_xref="UniProtKB/Swiss-Prot:P54489" /translation="MDKHPFPYNIRHKLSFFRDTFDIIIQNAHTLTVSWEISEETMRL AEAVLFEKTQDMIKELRIVIKRKDIEAVRTKRTTYDKGEWTIRQAAGDAVYRAEYRIV NSMNVSLKLAGTDDIYLDENGIRHINSFQIEEAHTRWEAQFSAYTCYGRGEKER*" /label="yqgL CDS" gene complement(2160481..2160951) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /label="yqgL gene" promotor_-35 2160896..2160904 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2160918..2160926 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2160919..2161092 /Source="Nicolas_S_feature" /locus_tag="new_2576155_2576328" /HighExp="M9-stat, T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, Lbstat, T3.30H, B60" /AntisenseName="yqgL" /AntisenseCor="0.210779859401483" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S935" upshifts 2160920 /Source="Nicolas_upshifts" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2160987..2161006) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2160999) /Source="Nicolas_upshifts" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2161018..2161025) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2161064..2161068 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2161084..2161103 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2161094 /Source="Nicolas_upshifts" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" CDS 2161131..2161484 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390372.1" /db_xref="EnsemblGenomes-Gn:BSU24930" /db_xref="EnsemblGenomes-Tr:CAB14423" /db_xref="GOA:O32022" /db_xref="SubtiList:BG13770" /db_xref="UniProtKB/Swiss-Prot:O32022" /translation="MEIAIIALFIVSIALIAFSYSQRDPMKDVEQELETLQLSAMQEI YKLKKKMTVLEEELLETNLVIRKSKQNDINQKIAKQILSKYNNGMSAEAIAKAEHVSV EDVNTIIKDNEKVLV*" /label="yqzD CDS" gene 2161131..2161484 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /label="yqzD gene" CDS 2161481..2161945 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390373.2" /db_xref="EnsemblGenomes-Gn:BSU24940" /db_xref="EnsemblGenomes-Tr:CAB14424" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13769" /db_xref="UniProtKB/Swiss-Prot:O32023" /translation="MTKRGIQAFAGGIILATAVLAAVFYLTDEDQAAAVKDNKTVTEQ DVNNYLDSKKLVSVNRDEYQKLLDSKEKSLNNDSGSDTKSDKVKTYKLTIKDGMSTAD VSAILEKEGIISSAQDFNDYVIDAGYHKEIRAGEFKVKSDMSFKKIVKTLTR*" /label="yqzC CDS" gene 2161481..2161945 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /label="yqzC gene" downshifts 2161931 /Source="Nicolas_upshifts" /id="D1293" /incds=0 /nref=216 /ntot=264 /MaxReadThrough="0.9847" /MaxDrop="6.07831" /score="21.2108939" /energy="-8.8" /TU="NA" /idTUdmin="U1934" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2161974..2162756) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390374.1" /db_xref="EnsemblGenomes-Gn:BSU24950" /db_xref="EnsemblGenomes-Tr:CAB14425" /db_xref="GOA:P46342" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11379" /db_xref="UniProtKB/Swiss-Prot:P46342" /translation="MSIATEAVMKQEVYQVNGMNLWYGQHHALKNINLSIYENEVTAI IGPSGCGKSTFIKTLNLMIQMTPNVKLAGELNYNGSNILKDKVDIVDLRKNIGMVFQK GNPFPQSIFDNVAYGPRVHGTKNKKKLQEIVEKSLKDVALWDEVKDRLHTSALSLSGG QQQRLCIARALATNPDILLMDEPTSALDPISTRKIEELILELKDKYTIVIVTHNMQQA ARVSDQTAFFYMGELVECDNTNKMFSNPKDQRTLDYISGKFG*" /label="pstBB CDS" gene complement(2161974..2162756) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /label="pstBB gene" downshifts complement(2161985) /Source="Nicolas_upshifts" /id="D1294" /incds=0 /nref=20 /ntot=46 /MaxReadThrough="2.29658" /MaxDrop="6.53816" /score="26.1659198" /energy="-8.8" /TU="NA" /idTUdmin="U1937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2162767..2163576) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390375.1" /db_xref="EnsemblGenomes-Gn:BSU24960" /db_xref="EnsemblGenomes-Tr:CAB14426" /db_xref="GOA:P46341" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11378" /db_xref="UniProtKB/Swiss-Prot:P46341" /translation="MSEQMVKEKPERAVIVPKQNHVLEVKDLSIYYGNKQAVHHVNMD IEKNAVTALIGPSGCGKSTFLRNINRMNDLIPSARAEGEILYEGLNILGGNINVVSLR REIGMVFQKPNPFPKSIYANITHALKYAGERNKAVLDEIVEESLTKAALWDEVKDRLH SSALSLSGGQQQRLCIARTLAMKPAVLLLDEPASALDPISNAKIEELITGLKREYSII IVTHNMQQALRVSDRTAFFLNGELVEYGQTEQIFTSPKKQKTEDYINGKFG*" /label="pstBA CDS" gene complement(2162767..2163576) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /label="pstBA gene" CDS complement(2163597..2164481) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390376.2" /db_xref="EnsemblGenomes-Gn:BSU24970" /db_xref="EnsemblGenomes-Tr:CAB14427" /db_xref="GOA:P46340" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR005672" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11377" /db_xref="UniProtKB/Swiss-Prot:P46340" /translation="MNRKITDKLATGMFGLCAAIIAAILVGLFSYIIINGVSQLSFQF ITTKSSAIAAGGGIRDQLFNSFYILFITMLITIPLGVGGGVFMAEYAPNNKVTDFIRT CIEVLSSLPSIVIGMFGLLMFVNLTGWGYTIIGGALALTVFNLPVMVRVTEDAIRSVP KDLKEASLALGVSRWHTVKTVLIPSAIPSIITGAILASGRVFGEAAALLFTAGLTTPR LNFTEWNPFSETSPLNIFRPAETLAVHIWNVNTQGMIPDAEAIANGGSAVLVISVLVF NLAARWLGTMIYKKLTAN*" /label="pstA CDS" gene complement(2163597..2164481) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /label="pstA gene" CDS complement(2164481..2165410) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390377.2" /db_xref="EnsemblGenomes-Gn:BSU24980" /db_xref="EnsemblGenomes-Tr:CAB14428" /db_xref="GOA:P46339" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011864" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11376" /db_xref="UniProtKB/Swiss-Prot:P46339" /translation="MINNRENMSVSERLISSRQNRQLDEVRGRMIVTACALIMIAASV AITIFLGVKGLQSFLVNGVSPIEFLTSLNWNPTDSDPKYGVLPFIFGSFAVTILSALI AAPLGIAGAIFMTEIAPNWGKKVLQPVIELLVGIPSVVYGFIGLTVLVPFIAQFKSSG TGHSLLAGTIVLSVMILPTITSISADAMASLPKSLREGSYALGATRWQTIRKVLVPAA FPTLMTAVVLGMARAFGEALAVQMVIGNTRVLPESPFDTAGTLTTIITLNMGHTTYGS VENNTLWSMGLVLLVMSFLFILLIRYLSSRRKV*" /label="pstC CDS" gene complement(2164481..2165410) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /label="pstC gene" CDS complement(2165479..2166381) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 9593301, 10913081, 15289558, 21461370, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 9593301, 10913081, 15289558, 21461370, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (phosphate binding lipoprotein)" /protein_id="NP_390378.1" /db_xref="EnsemblGenomes-Gn:BSU24990" /db_xref="EnsemblGenomes-Tr:CAB14429" /db_xref="GOA:P46338" /db_xref="InterPro:IPR011862" /db_xref="InterPro:IPR024370" /db_xref="SubtiList:BG11375" /db_xref="UniProtKB/Swiss-Prot:P46338" /translation="MKKNKLVLMLLMAAFMMIAAACGNAGESKKSNSDSAKGEEKASG SLTISGSSAMQPLVLAAAEKFMEENPDADIQVQAGGSGTGLSQVSEGAVQIGNSDVFA EEKEGIDAKALVDHQVAVVGMAAAVNPDAGVKDISKDELKKIFTGKIKNWKELGGKDQ KITLVNRPDSSGTRATFVKYALDGAEPAEGITEDSSNTVKKIIADTPGAIGYLAFSYL TDDKVTALSIDGVKPEAKNVATGEYPIWAYQHSYTKGEATGLAKEFLDYLKSEDIQKS IVTDQGYIPVTDMKVTRDANGKQS*" /label="pstS CDS" gene complement(2165479..2166381) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /label="pstS gene" upshifts complement(2166436) /Source="Nicolas_upshifts" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2166444..2166460) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2166471..2166473) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-35" Polymorphism join(2166490,2166492) /Source="geneious" /ID="SNP_BsDelta6_2581727_2581726" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)6 -> (T)7" /Codon_Change /Coverage=117 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=114 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2166536..2168686) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /EC_number="3.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9139922, 9851991, 12896990, 17307860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139922, 9851991, 12896990, 17307860; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transpeptidase (penicillin-binding protein 2A)" /protein_id="NP_390379.1" /db_xref="EnsemblGenomes-Gn:BSU25000" /db_xref="EnsemblGenomes-Tr:CAB14430" /db_xref="GOA:P54488" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11678" /db_xref="UniProtKB/Swiss-Prot:P54488" /translation="MRRNKPKKQNHKEKKKSLPIRLNILFLAAFVIFTWIIVELGIKQ IVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIVTNKALNAITYTRSKSTTQEQR LKIAKKLSDMIKVDTKKVTERDKKDYWILTRPKEAKKLISSKERQQVEDKKISDDDLY QLQLKRITDKQLNELTDKDMQILAIKRQMDSGYALTPQYIKNEDVSAKEMAVVSEHLD ELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNEGLPSNLLDHYLSLGYSRNDRVGKSY LEYQYESLLQGQKAKVENITDSKGNVTGTKTVSEGKAGKDLVLTIDIDLQKSVEKIIE KKLKAAKARPSTELLDRAFVVMMDPRNGEVLTMAGKQIKRENGAYKFDDYALGAMTSS YAMGSAVKGATVLTGLQTGAINLNTVFKDEPLYIGQDKRGKKSWQNLGPVGIQTALEK SSNVFMFKTAIAVGKGEYKPHQALPLDTSAFDTFRNYFSQFGLGVKTGIDLPNEMTGY KGTSRLSGFLLDFAIGQYDTYTPLELAQYVSTIANGGYRMKPQLVKEVRDSNAKKGIG AVVDSVQPEVLNKVDMKSSYIEEVQAGFRRVATKGTAAGQLASASYKPAAKTGTAQSF YDGPDKSKTGTDTYNTTLVAYAPADNPEIAISVVVPWTYIDYNQRYSITNEIGREVMD KYFELKSKQDKEGTQQKNKDKIEENAENTTSSDN*" /label="pbpA CDS" gene complement(2166536..2168686) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /label="pbpA gene" downshifts complement(2166546) /Source="Nicolas_upshifts" /id="D1295" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="1.22121" /MaxDrop="8.82988" /score="31.2726004" /energy="-10" /TU="U1940" /idTUdmin="U1938" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2167280..2167298) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2167288) /Source="Nicolas_upshifts" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2167314..2167320) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2167975..2167994) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2167992) /Source="Nicolas_upshifts" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2168008..2168017) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2168736..2168755) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2168741) /Source="Nicolas_upshifts" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2168771..2168775) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2168800..2170092) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390380.2" /db_xref="EnsemblGenomes-Gn:BSU25010" /db_xref="EnsemblGenomes-Tr:CAB14431" /db_xref="GOA:P54487" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11677" /db_xref="UniProtKB/Swiss-Prot:P54487" /translation="MSKLKKVIGDVDVNKGLLFLLTIGGLYSLGIALSNTFVNVYLWK QSGKFIDLAIYNLSIVTMQPITFYLAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGE TAASRLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGPIV AGFVISRLENNTGYTVIFSLSLSLFALAVVMSFFLKRRESKGRFMLSKVFGERHSNMN WRRITNAHFFQGLREGIFVFLISVFVFIETNSELALGTFGLVNSAVSFFAYYFASRLI KKKARKKSILLGGLILYGALFLILFHMSFSTLLTYGVFIAIGYPLLLVPYVSLTYDVI GRARHARKARIEYIVLREMFLNAGRIVSILCFLLIVALLKEDVGIPLSLAILGIGHPL IYYFVKDIRFKEKEGENETMEEDGQKRVTEPTLLKGER*" /label="yqgE CDS" gene complement(2168800..2170092) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /label="yqgE gene" promotor_-10 complement(2170115..2170126) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2170126) /Source="Nicolas_upshifts" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2170140..2170146) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2170199..2170807) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /EC_number="1.15.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Mn[2+]-dependent)" /protein_id="NP_390381.3" /db_xref="EnsemblGenomes-Gn:BSU25020" /db_xref="EnsemblGenomes-Tr:CAB14432" /db_xref="GOA:P54375" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="PDB:2RCV" /db_xref="SubtiList:BG11676" /db_xref="UniProtKB/Swiss-Prot:P54375" /translation="MAYELPELPYAYDALEPHIDKETMTIHHTKHHNTYVTNLNKAVE GNTALANKSVEELVADLDSVPENIRTAVRNNGGGHANHKLFWTLLSPNGGGEPTGALA EEINSVFGSFDKFKEQFAAAAAGRFGSGWAWLVVNNGKLEITSTPNQDSPLSEGKTPI LGLDVWEHAYYLNYQNRRPDYISAFWNVVNWDEVARLYSEAK*" /label="sodA CDS" gene complement(2170199..2170807) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /label="sodA gene" downshifts complement(2170214) /Source="Nicolas_upshifts" /id="D1296" /incds=0 /nref=265 /ntot=268 /MaxReadThrough="4.329" /MaxDrop="9.16338" /score="3.26408916" /energy="-8.1" /TU="U1943" /idTUdmin="U1942" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2170859..2170878) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2170870) /Source="Nicolas_upshifts" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2170872..2170940) /Source="Nicolas_S_feature" /locus_tag="new_2586107_2586175_c" /HighExp="Etha, Salt, Heat, LPhT, Gly, Sw, S4, LoTm, M9-stat, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigB" /TUlongPSig="0.999" /label="S936" promotor_-35 complement(2170893..2170900) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2170931..2170949) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2170940) /Source="Nicolas_upshifts" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2170964..2170970) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2170986..2171468) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390382.1" /db_xref="EnsemblGenomes-Gn:BSU25030" /db_xref="EnsemblGenomes-Tr:CAB14433" /db_xref="GOA:P54486" /db_xref="InterPro:IPR007403" /db_xref="SubtiList:BG11675" /db_xref="UniProtKB/Swiss-Prot:P54486" /translation="MDMLYWLLIAAVFIIAFIGLVYPVIPSVVFIVAGFVLYGFLFSF SPYSYMFWLVEAVFAAVLFAADYVSNLLGVKRFGGSKAAIWGSTIGLLIGPFVIPVAG IILGPFIGAVCAELIVHQKDLKSAFKIGLGSLIGFLTGVIAKGIIQLLMIGYFLWTVL *" /label="yqgC CDS" gene complement(2170986..2171468) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /label="yqgC gene" S_feature complement(2171469..2171761) /Source="Nicolas_S_feature" /locus_tag="new_2586704_2586996_c" /HighExp="Etha, Gly, Salt, aero, S0, LoTm, HiTm, LPh, nit, ferm" /AntisenseName="yqgB" /AntisenseCor="9.8584854910492598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S937" promotor_-35 2171511..2171517 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2171532..2171551 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2171545 /Source="Nicolas_upshifts" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="upshifts" CDS 2171578..2172345 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15294815; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390383.2" /db_xref="EnsemblGenomes-Gn:BSU25040" /db_xref="EnsemblGenomes-Tr:CAB14434" /db_xref="GOA:P54485" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG11674" /db_xref="UniProtKB/Swiss-Prot:P54485" /translation="MNVFQLFIKSTYSPRDIAKTRFQGIGKAILYVFLLSVLFAIPTA YYVSTGTVKSMNGFKTVLNKDFPDFTISNGKLQTDEKKATESQANGFVIVFDPTDSYG TEQIEAKQNAIGILQNKFVLAIDGQAQEMSYSMMPSELQKKDVIAGLNQNKAMIVTVL SALIFLVTAAGKFIEVSFLALIGLIIKNSQKKHLSYHQLWKLSAYSITLSTVFFTIMR ALEATVPSEFLLNWFVNFVILFLVLKEIPSKKVINKS*" /label="yqgB CDS" gene 2171578..2172345 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /label="yqgB gene" promotor_-10 complement(2171759..2171777) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-10" upshifts complement(2171761) /Source="Nicolas_upshifts" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="upshifts" S_feature complement(2171763..2172699) /Source="Nicolas_S_feature" /locus_tag="new_2586998_2587934_c" /HighExp="S0, S1, aero, M0t45, HPh, Lbtran, LPh, GM 120, nit, M/G" /AntisenseName="yqgB" /AntisenseCor="0.31978785018705103" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S938" promotor_-35 complement(2171791..2171797) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-35" S_feature 2172346..2172776 /Source="Nicolas_S_feature" /locus_tag="new_2587581_2588011" /HighExp="C30, HiOs, UNK1, Gly, Fru, S8, Salt, MG 5, S7, MG 25" /AntisenseName="yqgA" /AntisenseCor="0.170248276038857" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.731" /TUlongSig="NA" /TUlongPSig="NA" /label="S939" downshifts 2172733 /Source="Nicolas_upshifts" /id="D1297" /incds=0 /nref=5 /ntot=131 /MaxReadThrough="3.89102" /MaxDrop="3.29021" /score="30.8580926" /energy="-13.8" /TU="U1944" /idTUdmin="U1944" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(2172744) /Source="Nicolas_upshifts" /id="D1298" /incds=0 /nref=15 /ntot=207 /MaxReadThrough="6.7306" /MaxDrop="3.9194" /score="7.48192829" /energy="-14.3" /TU="U1947" /idTUdmin="U1945" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" CDS complement(2172761..2173189) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /experiment="publication(s) with functional evidences, PMID:25130749, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25130749, 27797724; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="cell wall protein" /protein_id="NP_390384.2" /db_xref="EnsemblGenomes-Gn:BSU25050" /db_xref="EnsemblGenomes-Tr:CAB14435" /db_xref="GOA:P54484" /db_xref="SubtiList:BG11673" /db_xref="UniProtKB/Swiss-Prot:P54484" /translation="MKQGKFSVFLILLLMLTLVVAPKEKAEAASSGWQPVSGISGCKI RVITDAYTYTKSATSIDAYAETNGKCGKLNYKSFGVSIVEGGDIGPQYSGYFSSRTPT KKFYFSKLPKPTGTPWAVGLSVYKGKAKGAAFVYINPQKR*" /label="yqgA CDS" gene complement(2172761..2173189) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /label="yqgA gene" promotor_-35 2173185..2173189 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-35" promotor_-10 2173199..2173213 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-10" upshifts 2173208 /Source="Nicolas_upshifts" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="upshifts" promotor_-10 complement(2173212..2173231) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-10" upshifts complement(2173235) /Source="Nicolas_upshifts" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="upshifts" promotor_-35 complement(2173246..2173253) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-35" promotor_-35 2173404..2173409 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2173425..2173443 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2173437 /Source="Nicolas_upshifts" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2173466..2173765 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15294815; Product type ph : phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390385.1" /db_xref="EnsemblGenomes-Gn:BSU25060" /db_xref="EnsemblGenomes-Tr:CAB14436" /db_xref="GOA:P54483" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR020506" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11672" /db_xref="UniProtKB/Swiss-Prot:P54483" /translation="MKRLTLVCSIVFILFILFYDLKIGTIPIQDLPVYEASAKTAVQE PAYKTVKVKPGDTVMSIVGSAGSPDDIVKDFEALNPNVKANAIQAGTAYKFPVYP*" /label="yqfZ CDS" gene 2173466..2173765 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /label="yqfZ gene" promotor_-35 2173778..2173785 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2173800..2173819 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2173811..2173887 /Source="Nicolas_S_feature" /locus_tag="new_2589046_2589122" /HighExp="Diami, dia5, dia15, H2O2, Etha, Salt, LBGexp, Oxctl, Paraq, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="Sig-" /TUlongPSig=0 /label="S940" upshifts 2173811 /Source="Nicolas_upshifts" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2173888..2175021 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /EC_number="1.17.7.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12571359, 16268586, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase)" /protein_id="NP_390386.1" /db_xref="EnsemblGenomes-Gn:BSU25070" /db_xref="EnsemblGenomes-Tr:CAB14437" /db_xref="GOA:P54482" /db_xref="InterPro:IPR004588" /db_xref="InterPro:IPR011005" /db_xref="InterPro:IPR016425" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11671" /db_xref="UniProtKB/Swiss-Prot:P54482" /translation="MQVSEITHRTKTRPVKVGPLTIGGNNEVVIQSMTTTKTHDVEAT VAEINRLAEAGCQIVRVACPDERAANAIADIKKRISIPLVVDIHFDYKLALKAIEGGA DKIRINPGNIGRREKVEAVVKAAKDKGIPIRIGVNAGSLEKRILEKYGYPTADGMVES ALHHIKILEDLDFHDIIVSMKASDVNLAIEAYEKAAKAFDYPLHLGITESGTLFAGTV KSAAGLGAILSKGIGNTMRISLSADPVEEVKVARELLKSFGLASNAATLISCPTCGRI EIDLISIANEVEEYISKIKAPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRKGK IVRKVPEETMVEELKKEIDILAEEHYAKLEAEKAKLKEETQKA*" /label="ispG CDS" gene 2173888..2175021 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /label="ispG gene" downshifts 2175002 /Source="Nicolas_upshifts" /id="D1299" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.62035" /MaxDrop="8.92434" /score="30.8580926" /energy="-13.8" /TU="NA" /idTUdmin="U1948" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(2175047..2175436) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function expressed in germinating spores" /protein_id="NP_390387.1" /db_xref="EnsemblGenomes-Gn:BSU25080" /db_xref="EnsemblGenomes-Tr:CAB14438" /db_xref="GOA:P54481" /db_xref="SubtiList:BG11670" /db_xref="UniProtKB/Swiss-Prot:P54481" /translation="MKVANDYEKRDNNSYYVDHGSEGTNITRDNDGFFEETAAEIAEP YRAADRSNDQDNDRSGGNVNEGRGIGYIALALSIISLFVLPVLLGAAGIIVGYIARRR GAQGLGAWAMGIGVVSLVLGIFIIPFF*" /label="yqfX CDS" gene complement(2175047..2175436) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /label="yqfX gene" downshifts complement(2175073) /Source="Nicolas_upshifts" /id="D1300" /incds=0 /nref=10 /ntot=62 /MaxReadThrough="1.85077" /MaxDrop="8.74353" /score="28.1764525" /energy="-13.8" /TU="NA" /idTUdmin="U1950" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2175467..2175478) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2175471) /Source="Nicolas_upshifts" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2175492..2175498) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2175511..2175518 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2175529..2175548 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2175530 /Source="Nicolas_upshifts" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="upshifts" CDS 2175569..2176150 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotidase" /protein_id="NP_390388.1" /db_xref="EnsemblGenomes-Gn:BSU25090" /db_xref="EnsemblGenomes-Tr:CAB14439" /db_xref="GOA:P54480" /db_xref="InterPro:IPR009206" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11669" /db_xref="UniProtKB/Swiss-Prot:P54480" /translation="MLRLGIDIDGTITAQDTFVPYLNRSFNLSISLNDMTDYDLTKLL NITQEEFWDWMNQNEAIIYKEALLAQHAKQSLDLLKEEHKLIYITARRTHLTDITYEW FDRQNIHYDHIELVGGHHKVEAVKNHNIDLFFEDHHGNAMMIAKEAGIPVILFNSPYN QLPIDSNIIRVNNWLEAVQWMNNNKHHLIRVNN*" /label="yqfW CDS" gene 2175569..2176150 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /label="yqfW gene" downshifts 2176148 /Source="Nicolas_upshifts" /id="D1301" /incds=0 /nref=34 /ntot=240 /MaxReadThrough="4.07255" /MaxDrop="4.44714" /score="-2.90660182" /energy="-8" /TU="U1951" /idTUdmin="U1951" /TUdmin="-611" /isTUend="FALSE" /label="downshifts" S_feature 2176193..2176801 /Source="Nicolas_S_feature" /locus_tag="new_2591428_2592036" /HighExp="LoTm, S8, Cold, S7, S5, Sw, BC, S6, HiOs, B60" /AntisenseName="zur" /AntisenseCor="-0.265512398914523" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S941" CDS complement(2176193..2176630) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Zn[2+]-binding Fur family)" /protein_id="NP_390389.2" /db_xref="EnsemblGenomes-Gn:BSU25100" /db_xref="EnsemblGenomes-Tr:CAB14440" /db_xref="GOA:P54479" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11668" /db_xref="UniProtKB/Swiss-Prot:P54479" /translation="MNVQEALNLLKENGYKYTNKREDMLQLFADSDRYLTAKNVLSAL NDDYPGLSFDTIYRNLSLYEELGILETTELSGEKLFRFKCSFTHHHHHFICLACGKTK EIESCPMDKLCDDLDGYQVSGHKFEIYGTCPDCTAENQENTTA*" /label="zur CDS" gene complement(2176193..2176630) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /label="zur gene" downshifts complement(2176197) /Source="Nicolas_upshifts" /id="D1302" /incds=0 /nref=181 /ntot=243 /MaxReadThrough="2.37371" /MaxDrop="6.74703" /score="16.4418277" /energy="-11.9" /TU="U1956" /idTUdmin="U1952" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2176631..2176725) /Source="Nicolas_S_feature" /locus_tag="new_2591866_2591960_c" /HighExp="LPhT, G180, Cold, LBGstat, H2O2, Oxctl, G135, G150, HPh, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S942" promotor_-10 complement(2176721..2176740) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2176725) /Source="Nicolas_upshifts" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2176755..2176762) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2176768..2177649) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390390.2" /db_xref="EnsemblGenomes-Gn:BSU25110" /db_xref="EnsemblGenomes-Tr:CAB14441" /db_xref="GOA:P54478" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11667" /db_xref="UniProtKB/Swiss-Prot:P54478" /translation="MTPTKQHKKETFTHFIFRVFMILVGAASAAVSIELFLIPNDFID GGIIGVSLILDHLFMSNPFLNFAFFVVILNIPFMIFGYKYIGKTFLVSTFIGIVGLAV IESSLHHVEAITTQPILATVFGGLLLGFGVGLVIRNGGSMDGTEILGILLTKKLPFSV GEFVMFINVFIFIWAVFVFGPEQAMYSFMTYYIAMKTIDAVIQGLDETKAVIIVSEQY DEISDAILHRLGRGTTKLKGKGGYTDEEKDVIYAVVTRLEVTKLKSIVFEVDQNAFIT IMNTHETRGGKFKNAIH*" /label="yqfU CDS" gene complement(2176768..2177649) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /label="yqfU gene" promotor_-35 2177645..2177650 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2177666..2177684 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2177682 /Source="Nicolas_upshifts" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2177687..2177706) /Source="Nicolas_upshift_promotors" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2177693) /Source="Nicolas_upshifts" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2177695..2178022) /Source="Nicolas_S_feature" /locus_tag="new_2592930_2593257_c" /HighExp="Cold, T-4.40H, T-5.40H, Salt, GM-0.1, BMM, UNK1, MG 25, GM-0.2, SMM" /AntisenseName="yqfT" /AntisenseCor="-0.62379514374156597" /AntisenseRegPval="-29.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S943" promotor_-35 2177711..2177720 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2177727 /Source="Nicolas_upshifts" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2177733..2177752 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2177765..2178019 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390391.1" /db_xref="EnsemblGenomes-Gn:BSU25120" /db_xref="EnsemblGenomes-Tr:CAB14442" /db_xref="InterPro:IPR020277" /db_xref="SubtiList:BG11666" /db_xref="UniProtKB/Swiss-Prot:P54477" /translation="MILFQRIILQRLNQATADDLLKYSKQYGISLTRSQAVEVANLLY GKNVNIFNESERMRLLKQVETITSKETAQTVNELFKQFTS*" /label="yqfT CDS" gene 2177765..2178019 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /label="yqfT gene" downshifts 2178006 /Source="Nicolas_upshifts" /id="D1303" /incds=0 /nref=12 /ntot=72 /MaxReadThrough="3.97414" /MaxDrop="7.03976" /score="24.5413663" /energy="-9.8" /TU="U1953" /idTUdmin="U1955" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2178046..2178939) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /EC_number="3.1.21.2" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type IV apurinic/apyrimidinic endonuclease" /protein_id="NP_390392.1" /db_xref="EnsemblGenomes-Gn:BSU25130" /db_xref="EnsemblGenomes-Tr:CAB14443" /db_xref="GOA:P54476" /db_xref="InterPro:IPR001719" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR018246" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11665" /db_xref="UniProtKB/Swiss-Prot:P54476" /translation="MLRIGSHVSMSGKHMLLAASQEAVSYGANTFMIYTGAPQNTRRK KIEDLNIEAGRAHMQENGIDEIIVHAPYIINIGNTTNPSTFELGVDFLRSEIERTAAI GAKQIVLHPGAHVGAGAEAGIKKIIEGLNEVIDPNQNVQIALETMAGKGSECGRSFEE LAQIIEGVTHNEQLSVCFDTCHTHDAGYNIVEDFDGVLNEFDKIIGIDRIKVLHINDS KNVKGARKDRHENIGFGEIGFDALQYVVHHEQLKDIPKILETPYVGEDKKNKKPPYRF EIEMLKEKQFDDTLLEKILQQ*" /label="nfo CDS" gene complement(2178046..2178939) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /label="nfo gene" S_feature 2178051..2178852 /Source="Nicolas_S_feature" /locus_tag="new_2593286_2594087" /HighExp="S6, S7, C30, S8, S5, G135, C90, Gly, LoTm, Sw" /AntisenseName="nfo" /AntisenseCor="-0.36683479556464399" /AntisenseRegPval="-9.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S944" downshifts complement(2178067) /Source="Nicolas_upshifts" /id="D1304" /incds=0 /nref=46 /ntot=187 /MaxReadThrough="4.82641" /MaxDrop="6.05328" /score="16.7756411" /energy="-9.8" /TU="U1956" /idTUdmin="U1952" /TUdmin="-1870" /isTUend="FALSE" /label="downshifts" CDS complement(2178949..2180265) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 16352840, 18203828, 20572937, 23175651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16352840, 18203828, 20572937, 23175651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_390393.1" /db_xref="EnsemblGenomes-Gn:BSU25140" /db_xref="EnsemblGenomes-Tr:CAB14444" /db_xref="GOA:P54475" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030881" /db_xref="SubtiList:BG11664" /db_xref="UniProtKB/Swiss-Prot:P54475" /translation="MKETKFELYELKPFIIDAVHRLGFYEPTDIQKRLIPAVLKKESV IGQSQTGTGKTHAYLLPLLNKIDPAKDVVQVVITAPTRELANQIYQEALKITQGEEGS QIRSKCFIGGTDKQKSIDKLKIQPHLVVGTPGRIADLIKEQALSVHKAESLVIDEADL MLDMGFLADVDYIGSRMPEDLQMLVFSATIPEKLKPFLKKYMENPKYAHVEPKQVTAA KIEHILIPSKHRDKDKLLFDIMSHLNPYLGIVFANTKNTADHIAQYLTGKGMKIGLLH GGLTPRERKKVMKQINDLEFTYIIATDLAARGIDIKGVSHVINYELPDDLDFYVHRVG RTARAGSSGQAMTIYELTDEDALVRLEKMGIEFEYLELEKGEWKKGDDRQRRKKRKKT PNEADEIAHRLVKKPKKVKPGYKKKMSYEMEKIKKKQRRNQSKKRK*" /label="cshB CDS" gene complement(2178949..2180265) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /label="cshB gene" promotor_-10 complement(2180301..2180320) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2180312) /Source="Nicolas_upshifts" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2180336..2180340) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2180369..2180378 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2180390 /Source="Nicolas_upshifts" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2180392..2180411 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2180434..2181177 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390394.1" /db_xref="EnsemblGenomes-Gn:BSU25150" /db_xref="EnsemblGenomes-Tr:CAB14445" /db_xref="InterPro:IPR025571" /db_xref="SubtiList:BG11663" /db_xref="UniProtKB/Swiss-Prot:P54474" /translation="MFSPQQPMRNYPQPGPPRPMPNQRMMGRRPPNMRGPSFGAQQQG FQQAGQFLPQANAGARNGAGAGGGLKGMLSRFLPGGGGAGSAGVPGIPGAGAAASGGA GLQGIQNIANPASLSSMLGNVQKVLGMAQQVTPMIQQYGPLVRNLPAMMKLYSQLSKS DDTETEANEESEKQSVSEESSEKEKETETKTSDGNKKSKPKSSSLPKKSKTTDNKEQE LKTSAPKKKEAASPAPKRTSGSSKPRLYI*" /label="yqfQ CDS" gene 2180434..2181177 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /label="yqfQ gene" downshifts 2181159 /Source="Nicolas_upshifts" /id="D1305" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="5.46594" /MaxDrop="3.2445" /score="4.32537428" /energy="-6.8" /TU="U1957" /idTUdmin="U1957" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" promotor_-35 2181181..2181188 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2181202..2181221 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2181204..2181299 /Source="Nicolas_S_feature" /locus_tag="new_2596439_2596534" /HighExp="S8, S7, S6, Cold, H2O2, Salt, dia15, G180, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S945" upshifts 2181204 /Source="Nicolas_upshifts" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="upshifts" CDS 2181300..2182244 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /EC_number="1.17.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12706830, 15381396, 15469281, 17458547, 27169371; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase" /protein_id="NP_390395.2" /db_xref="EnsemblGenomes-Gn:BSU25160" /db_xref="EnsemblGenomes-Tr:CAB14446" /db_xref="GOA:P54473" /db_xref="InterPro:IPR003451" /db_xref="SubtiList:BG11662" /db_xref="UniProtKB/Swiss-Prot:P54473" /translation="MDVIKISPRGYCYGVVDAMVIAKNASLDKSLPRPIYILGMIVHN KHVTDAFEEEGIFTLDGSNRLDILKQVDKGTVIFTAHGVSPEVRRIAEEKGLVAIDAT CPDVTKTHNLILEMKEKGYHVIYIGKKGHPEPEGAVGVAPEIVHLVETEEDVKNLDIQ SEKLIVTNQTTMSQWDVHDIMELVKEKYPHVEYHQEICLATQVRQEAVSEQAKKADLT IVVGDPKSNNSNRLAQVSEEIAGTKAYRIGDLSELKLEWLKGVNTVAVTAGASTPTPI TKEVIRFLEQFDHEDPSTWTTEHNIPLKKILPKVKAKN*" /label="ispH CDS" gene 2181300..2182244 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /label="ispH gene" downshifts 2182215 /Source="Nicolas_upshifts" /id="D1306" /incds=0 /nref=106 /ntot=243 /MaxReadThrough="4.04288" /MaxDrop="5.66904" /score="29.529951" /energy="-12.2" /TU="U1958" /idTUdmin="U1957" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2182267..2183388) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17187687, 17586767; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative GTP cyclohydrolase" /protein_id="NP_390396.1" /db_xref="EnsemblGenomes-Gn:BSU25170" /db_xref="EnsemblGenomes-Tr:CAB14447" /db_xref="GOA:P54472" /db_xref="InterPro:IPR002678" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017221" /db_xref="InterPro:IPR036069" /db_xref="SubtiList:BG11661" /db_xref="UniProtKB/Swiss-Prot:P54472" /translation="MAKSVNGQQIIQLFEQFSPKAYAVEGDKIGLQIGTLNKPIKNVM VTLDVLESVIDEAIEKEVDLIIAHHPPIFRSLKHISTDQPAGRLIEKCLKHDIAVYAA HTNLDVADGGVNDLLAEALELSETEVLAPTYTDPLKKLAVYVPKEYEEQVRAALGNAG AGHIGEYSHCAFSSEGIGSFKPLDGAKPFIGEVGELELVHEVRLETVFPKSVEKAVIN AMIKSHPYEEVAYDIYPVEQTPAEKGLGRVGTLKNEMTLKEFALFVKDKLDVNGVRMV GDADSMVKKVAVLGGDGNKYIHHAKRKGADVYVTGDLYFHVAHDAMMLGLNVVDPGHY AEKIMKEGVTRKLTSMCNDKKFGVNIFVSETDTNPFTFL*" /label="yqfO CDS" gene complement(2182267..2183388) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /label="yqfO gene" downshifts complement(2182292) /Source="Nicolas_upshifts" /id="D1307" /incds=0 /nref=63 /ntot=224 /MaxReadThrough="3.241" /MaxDrop="4.76436" /score="27.9821938" /energy="-12.2" /TU="NA" /idTUdmin="U1959" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2183381..2184031) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /EC_number="2.1.1.217" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:18420655, 27098549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18420655, 27098549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (adenine(22)-N(1))-methyltransferase" /protein_id="NP_390397.1" /db_xref="EnsemblGenomes-Gn:BSU25180" /db_xref="EnsemblGenomes-Tr:CAB14448" /db_xref="GOA:P54471" /db_xref="InterPro:IPR006901" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11660" /db_xref="UniProtKB/Swiss-Prot:P54471" /translation="MADIGSDHAYLPCYAVLNHKASGAIAGEITDGPFLSAKRQVEKS GLNSHISVRQGDGLEVIKKGEADAITIAGMGGALIAHILEAGKDKLTGKERLILQPNI HAVHIREWLYKERYALIDEVILEEDGKCYEVLVAEAGDRDAAYDGISLSAGMLVGPFL AKEKNAVFLKKWTQELQHTQSIYEQISQAADTEQNKQKLKELADRMELLKEVIDHG*" /label="trmK CDS" gene complement(2183381..2184031) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /label="trmK gene" S_feature complement(2184032..2184140) /Source="Nicolas_S_feature" /locus_tag="new_2599267_2599375_c" /HighExp="LBGexp, LBGtran, dia15, dia0, Lbexp, G150, G180, LBGstat, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S946" promotor_-10 complement(2184128..2184147) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2184140) /Source="Nicolas_upshifts" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2184142..2184255) /Source="Nicolas_S_feature" /locus_tag="new_2599377_2599490_c" /HighExp="Lbstat, M0t90, M9-stat, S2, T1.0H, T1.30H, T2.30H, T3.0H, S7, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S947" promotor_-35 complement(2184163..2184167) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2184288..2184650) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10024472, 10473570, 11361075, 15995641, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024472, 10473570, 11361075, 15995641, 19222757; Product type c: carrier" /codon_start=1 /transl_table=11 /product="cytochrome c550" /protein_id="NP_390398.1" /db_xref="EnsemblGenomes-Gn:BSU25190" /db_xref="EnsemblGenomes-Tr:CAB14449" /db_xref="GOA:P24469" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10315" /db_xref="UniProtKB/Swiss-Prot:P24469" /translation="MKWNPLIPFLLIAVLGIGLTFFLSVKGLDDSREIASGGESKSAE KKDANASPEEIYKANCIACHGENYEGVSGPSLKGVGDKKDVAEIKTKIEKGGNGMPSG LVPADKLDDMAEWVSKIK*" /label="cccA CDS" gene complement(2184288..2184650) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /label="cccA gene" downshifts complement(2184300) /Source="Nicolas_upshifts" /id="D1308" /incds=0 /nref=3 /ntot=88 /MaxReadThrough="4.32389" /MaxDrop="3.4795" /score="-4.13120914" /energy="-7.6" /TU="U1961,U1962" /idTUdmin="U1968" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-35 2184646..2184650 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2184658..2184672 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2184679 /Source="Nicolas_upshifts" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2184687..2184706) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2184689) /Source="Nicolas_upshifts" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2184691..2184812) /Source="Nicolas_S_feature" /locus_tag="new_2599926_2600047_c" /HighExp="Lbstat, T3.0H, T1.30H, M9-stat, T2.30H, T1.0H, T2.0H, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S948" promotor_-35 complement(2184718..2184725) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2184801..2184820) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2184809..2184828 /Source="Nicolas_upshift_promotors" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2184812) /Source="Nicolas_upshifts" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2184814..2184953) /Source="Nicolas_S_feature" /locus_tag="new_2600049_2600188_c" /HighExp="Lbstat, S8, S1, S7, G/S, BT, Mal, Gly, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S949" S_feature 2184815..2184919 /Source="Nicolas_S_feature" /locus_tag="new_2600050_2600154" /HighExp="T2.30H, M9-stat, T3.0H, T1.30H, T2.0H, T1.0H, T3.30H, T4.0H, M0t90, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S950" upshifts 2184815 /Source="Nicolas_upshifts" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2184834..2184840) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2184883..2184890 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2184904..2184923 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2184921..2187070 /Source="Nicolas_S_feature" /locus_tag="new_2600156_2602305" /HighExp="S2, T4.0H, T5.0H, Lbstat, M9-stat, T3.30H, S8, T3.0H, C30, T2.0H" /AntisenseName="sigA" /AntisenseCor="-0.16938350693676901" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S951" upshifts 2184921 /Source="Nicolas_upshifts" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2184979..2186094) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12455702, 12682299, 14527287, 15060039, 15670950, 28648455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12455702, 12682299, 14527287, 15060039, 15670950, 28648455; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase major sigma-43 factor (sigma-A)" /protein_id="NP_390399.2" /db_xref="EnsemblGenomes-Gn:BSU25200" /db_xref="EnsemblGenomes-Tr:CAB14450" /db_xref="GOA:P06224" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007127" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR009042" /db_xref="InterPro:IPR012760" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR028630" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10314" /db_xref="UniProtKB/Swiss-Prot:P06224" /translation="MADKQTHETELTFDQVKEQLTESGKKRGVLTYEEIAERMSSFEI ESDQMDEYYEFLGEQGVELISENEETEDPNIQQLAKAEEEFDLNDLSVPPGVKINDPV RMYLKEIGRVNLLSAKEEIAYAQKIEEGDEESKRRLAEANLRLVVSIAKRYVGRGMLF LDLIQEGNMGLMKAVEKFDYRKGYKFSTYATWWIRQAITRAIADQARTIRIPVHMVET INKLIRVQRQLLQDLGREPTPEEIAEDMDLTPEKVREILKIAQEPVSLETPIGEEDDS HLGDFIEDQEATSPSDHAAYELLKEQLEDVLDTLTDREENVLRLRFGLDDGRTRTLEE VGKVFGVTRERIRQIEAKALRKLRHPSRSKRLKDFLE*" /label="sigA CDS" gene complement(2184979..2186094) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /label="sigA gene" downshifts complement(2184998) /Source="Nicolas_upshifts" /id="D1309" /incds=0 /nref=118 /ntot=198 /MaxReadThrough="4.93947" /MaxDrop="6.16048" /score="4.75833607" /energy="-11.7" /TU="U1966,U1968,U1969,U1970,U1972,U1973" /idTUdmin="U1970" /TUdmin="-287" /isTUend="FALSE" /label="downshifts" S_feature complement(2186095..2186292) /Source="Nicolas_S_feature" /locus_tag="new_2601330_2601527_c" /HighExp="BC, Cold, SMMPr, S1, BI, G135, C30, Lbstat, S5, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S952" CDS complement(2186293..2188104) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /EC_number="2.7.7.-" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3100394, 9387153, 12682299, 16036556, 28386108; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA primase" /protein_id="NP_390400.2" /db_xref="EnsemblGenomes-Gn:BSU25210" /db_xref="EnsemblGenomes-Tr:CAB14451" /db_xref="GOA:P05096" /db_xref="InterPro:IPR002694" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR006295" /db_xref="InterPro:IPR013264" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR019475" /db_xref="InterPro:IPR030846" /db_xref="InterPro:IPR034151" /db_xref="InterPro:IPR036185" /db_xref="InterPro:IPR036977" /db_xref="InterPro:IPR037068" /db_xref="PDB:5GUJ" /db_xref="SubtiList:BG10313" /db_xref="UniProtKB/Swiss-Prot:P05096" /translation="MGNRIPDEIVDQVQKSADIVEVIGDYVQLKKQGRNYFGLCPFHG ESTPSFSVSPDKQIFHCFGCGAGGNVFSFLRQMEGYSFAESVSHLADKYQIDFPDDIT VHSGARPESSGEQKMAEAHELLKKFYHHLLINTKEGQEALDYLLSRGFTKELINEFQI GYALDSWDFITKFLVKRGFSEAQMEKAGLLIRREDGSGYFDRFRNRVMFPIHDHHGAV VAFSGRALGSQQPKYMNSPETPLFHKSKLLYNFYKARLHIRKQERAVLFEGFADVISA VSSDVKESIATMGTSLTDDHVKILRRNVEEIILCYDSDKAGYEATLKASELLQKKGCK VRVAMIPDGLDPDDYIKKFGGEKFKNDIIDASVTVMAFKMQYFRKGKNLSDEGDRLAY IKDVLKEISTLSGSLEQEVYVKQLASEFSLSQESLTEQLSVFSKQNKPADNSGETKTR RAHLTTKARQKRLRPAYENAERLLLAHMLRDRSVIKKVIDRVGFQFNIDEHRALAAYL YAFYEEGAELTPQHLMARVTDDHISQLLSDILMLQVNQELSEAELSDYVKKVLNQRNW SMIKEKEAERAEAERQKDFLRAASLAQEIVTLNRSLK*" /label="dnaG CDS" gene complement(2186293..2188104) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /label="dnaG gene" promotor_-35 2187699..2187705 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2187715 /Source="Nicolas_upshifts" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2187717..2187736 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2187744..2188040 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 9864351" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_054587.1" /db_xref="EnsemblGenomes-Gn:BSU25220" /db_xref="EnsemblGenomes-Tr:CAE01462" /db_xref="GOA:Q7WY63" /db_xref="SubtiList:BG14178" /db_xref="UniProtKB/Swiss-Prot:Q7WY63" /translation="MPQPFFVLQKTLAGLRNGLLYHLENQFGICQQGEKPTRQKNSLP SALKKRKHCRPLRSQSNEKSVCRAIRKTKVCFLHEKDRVQSSFGLASLIEHNHL*" /label="antE CDS" gene 2187744..2188040 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /label="antE gene" CDS complement(2188138..2188632) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9387153, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390401.2" /db_xref="EnsemblGenomes-Gn:BSU25230" /db_xref="EnsemblGenomes-Tr:CAB14452" /db_xref="InterPro:IPR003791" /db_xref="SubtiList:BG10312" /db_xref="UniProtKB/Swiss-Prot:P17868" /translation="MEGWRITLLNEQEKTIFVDADACPVKDEILQTASEYEVQVLFVA SFEHYQLSRSNEEKWKYVDPHKEAADLYIANHVKPGDIVVTQDIGLASLLLNRNVSVM SERGRLYKEDTIDFALEGRHFSGKQRRKGVYAKGPKKLNKEDRERFITLLQKILSNDE GILH*" /label="yqxD CDS" gene complement(2188138..2188632) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /label="yqxD gene" promotor_-10 complement(2188605..2188623) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2188616) /Source="Nicolas_upshifts" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2188633..2188746) /Source="Nicolas_S_feature" /locus_tag="new_2603868_2603981_c" /HighExp="S5, S4, S6, S7, S8, S3, Etha, dia15, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S953" promotor_-35 complement(2188635..2188643) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-35 2188641..2188646 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2188662..2188680 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2188677 /Source="Nicolas_upshifts" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2188731..2188749) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2188746) /Source="Nicolas_upshifts" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2188748..2188825) /Source="Nicolas_S_feature" /locus_tag="new_2603983_2604060_c" /HighExp="Etha, G180, G135, G150, LBGtran, LBGexp, dia15, H2O2, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S954" promotor_-35 complement(2188765..2188770) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2188791..2188810) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2188825) /Source="Nicolas_upshifts" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2188826..2188829) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2188886..2189698) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 20044937" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 20044937; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional ADP-dependent kinase-Pi-dependent pyrophosphorylase / positive regulator of gluconeogenesis" /protein_id="NP_390402.1" /db_xref="EnsemblGenomes-Gn:BSU25240" /db_xref="EnsemblGenomes-Tr:CAB14453" /db_xref="GOA:P54470" /db_xref="InterPro:IPR005177" /db_xref="InterPro:IPR026565" /db_xref="SubtiList:BG11659" /db_xref="UniProtKB/Swiss-Prot:P54470" /translation="MNNRIIYVVSDSVGETAELVVKAALSQFNGSADDTHVRRIPYVE DIGTINEVISLAKADGGIICFTLVVPEIREYLIAEAEKANVLYYDIIGPLIDKMETAY GLTAKYEPGRVRQLDEDYFKKVEAIEFAVKYDDGRDPRGILKADIVLIGVSRTSKTPL SQYLAHKRLKVANVPIVPEVDPPEELFNVDPKKCIGLKISPDKLNHIRKERLKSLGLN DKAIYANINRIKEELEYFEKIVDRIGCQVVDVSNKAVEETANIIHHLKTKNI*" /label="ppsR CDS" gene complement(2188886..2189698) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /label="ppsR gene" CDS complement(2189724..2190362) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of gluconeogenesis" /protein_id="NP_390403.1" /db_xref="EnsemblGenomes-Gn:BSU25250" /db_xref="EnsemblGenomes-Tr:CAB14454" /db_xref="GOA:O34994" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016842" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3FV6" /db_xref="PDB:3FWR" /db_xref="PDB:3FWS" /db_xref="SubtiList:BG13768" /db_xref="UniProtKB/Swiss-Prot:O34994" /translation="MSTIELNKRQEHILQIVKENGPITGEHIAEKLNLTRATLRPDLA ILTMSGFLEARPRVGYFYTGKTGTQLLADKLKKLQVKDFQSIPVVIHENVSVYDAICT MFLEDVGTLFVVDRDAVLVGVLSRKDLLRASIGQQELTSVPVHIIMTRMPNITVCRRE DYVMDIAKHLIEKQIDALPVIKDTDKGFEVIGRVTKTNMTKILVSLSENEIL*" /label="ccpN CDS" gene complement(2189724..2190362) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /label="ccpN gene" S_feature complement(2190363..2190494) /Source="Nicolas_S_feature" /locus_tag="new_2605598_2605729_c" /HighExp="G135, dia5, G180, G150, dia15, H2O2, LBGexp, Lbexp, Oxctl, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999, 0.998" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S955" promotor_-10 complement(2190488..2190507) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" CDS complement(2190495..2192534) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (beta subunit)" /protein_id="NP_390404.2" /db_xref="EnsemblGenomes-Gn:BSU25260" /db_xref="EnsemblGenomes-Tr:CAB14455" /db_xref="GOA:P54381" /db_xref="InterPro:IPR006194" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR015944" /db_xref="SubtiList:BG11658" /db_xref="UniProtKB/Swiss-Prot:P54381" /translation="MSKQDLLLEIGLEEMPARFLNESMVQLGDKLTGWLKEKNITHGE VKLFNTPRRLAVFVKDVAEKQDDIKEEAKGPAKKIALDADGNWTKAAIGFSKGQGANV EDLYIKEVKGIEYVFVQKFQAGQETKSLLPELSGLITSLHFPKNMRWGNEDLRYIRPI KWIVALFGQDVIPFSITNVESGRTTQGHRFLGHEVSIESPSAYEEQLKGQHVIADPSV RKQMIQSQLETMAAENNWSIPVDEDLLDEVNHLVEYPTALYGSFESEFLSIPEEVLVT TMKEHQRYFPVKDKNGDLLPHFITVRNGNSHAIENVARGNEKVLRARLSDASFFYKED QKLNIDANVKKLENIVFHEELGSLADKVRRVTSIAEKLAVRLQADEDTLKHVKRAAEI SKFDLVTHMIYEFPELQGIMGEKYARMLGEDEAVAAAVNEHYMPRSAGGETPSTFTGA VVAMADKLDTIASFFSIGVIPTGSQDPYGLRRQASGIVAILLDRNWGISFEELLTFVQ TDKENELLDFFTQRLKYVLNAEQIRHDVIDAVLESSELEPYSALHKAQVLEQKLGAPG FKETAEALGRVISISKKGVRGDIQPDLFENEYEAKLFDAYQTAKQNLQENFSKKDYEA ALASLAALKEPIDAYFDHTMVIADNESLKANRLAQMVSLADEIKSFANMNALIVK*" /label="glyS CDS" gene complement(2190495..2192534) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /label="glyS gene" upshifts complement(2190497) /Source="Nicolas_upshifts" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2190522..2190529) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" downshifts complement(2190541) /Source="Nicolas_upshifts" /id="D1310" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="6.14024" /MaxDrop="3.62589" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" downshifts complement(2190607) /Source="Nicolas_upshifts" /id="D1311" /incds=1 /nref=10 /ntot=162 /MaxReadThrough="6.17154" /MaxDrop="3.30313" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1386" /isTUend="FALSE" /label="downshifts" CDS complement(2192527..2193414) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390405.1" /db_xref="EnsemblGenomes-Gn:BSU25270" /db_xref="EnsemblGenomes-Tr:CAB14456" /db_xref="GOA:P54380" /db_xref="InterPro:IPR002310" /db_xref="InterPro:IPR006194" /db_xref="SubtiList:BG11657" /db_xref="UniProtKB/Swiss-Prot:P54380" /translation="MNIQDMILTLQKHWSSQGCVLMQAYDVEKGAGTMSPYTFLRSIG PEPWKVAYVEPSRRPADGRYGENPNRLYQHHQFQVIIKPSPDNIQELYLDSLRALGID PLEHDIRFVEDNWENPSLGCAGLGWEVWLDGMEITQFTYFQQVGGLECKPVSVEITYG IERLASYIQDKENVFDLEWTSGFTVKDLFMMAEYEHSVYTFETSDVDMLFQLFSTYEK EAIKQMDNGLVHPAYDYVLKCSHTFNLLDAKGAISVTERTGYIARVRNLARKVAKTYY EEREKLGFPMLKGEGSSHE*" /label="glyQ CDS" gene complement(2192527..2193414) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /label="glyQ gene" misc_RNA complement(2193497..2193671) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /product="T-box riboswitch controlling synthesis of glycine-tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201, 15890195, 26229106" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201, 15890195, 26229106; Product type n : RNA" /label="tboG RNA" gene complement(2193497..2193671) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /label="tboG gene" downshifts complement(2193531) /Source="Nicolas_upshifts" /id="D1312" /incds=0 /nref=70 /ntot=220 /MaxReadThrough="6.60948" /MaxDrop="5.42847" /score="18.9025126" /energy="-23.3" /TU="U1972,U1973,U1975" /idTUdmin="U1976" /TUdmin=178 /isTUend="FALSE" /label="downshifts" promotor_-35 2193646..2193651 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2193667..2193685 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2193675..2193694) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" S_feature 2193677..2195089 /Source="Nicolas_S_feature" /locus_tag="new_2608912_2610324" /HighExp="C30, S8, Gly, BT, G135, Fru, S6, C90, Lbstat, Mal" /AntisenseName="recO" /AntisenseCor="0.22892689952134901" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S956" upshifts 2193677 /Source="Nicolas_upshifts" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2193687) /Source="Nicolas_upshifts" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2193709..2193716) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2193711..2194478) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10323239, 15186413, 16061691, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10323239, 15186413, 16061691, 26001966; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA double strand break repair and homologous recombination factor" /protein_id="NP_390406.2" /db_xref="EnsemblGenomes-Gn:BSU25280" /db_xref="EnsemblGenomes-Tr:CAB14457" /db_xref="GOA:P42095" /db_xref="InterPro:IPR003717" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022572" /db_xref="SubtiList:BG11189" /db_xref="UniProtKB/Swiss-Prot:P42095" /translation="MLTKCEGIVLRTNDYGETNKIVTLLTREHGKIGVMARGAKKPNS RLSAVSQPFLYGSFLMQKTSGLGTLQQGEMILSMRGIREDLFLTAYAAYVAELVDRGT EEKKPNPYLFEFILESLKQLNEGTDPDVITFIVQMKMLGVMGLYPELNHCVHCKSQDG TFHFSVRDNGFICHRCFEKDPYRIPIKPQTARLLRLFYYFDLSRLGNVSLKEETKAEL KQVIDLYYEEYSGLYLKSKRFLDQMESMKHLMGENKS*" /label="recO CDS" gene complement(2193711..2194478) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /label="recO gene" CDS complement(2194515..2194658) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097761.1" /db_xref="EnsemblGenomes-Gn:BSU25289" /db_xref="EnsemblGenomes-Tr:CAX52661" /db_xref="InterPro:IPR025617" /db_xref="UniProtKB/Swiss-Prot:C0H452" /translation="MLNFTWNVFSQTGNVDTYLLFKELEKENMERPEELEDELARFDY PIL*" /label="yqzL CDS" gene complement(2194515..2194658) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /label="yqzL gene" S_feature complement(2194659..2194805) /Source="Nicolas_S_feature" /locus_tag="new_2609894_2610040_c" /HighExp="Lbstat, T1.30H, T2.0H, M9-stat, S2, T3.0H, S5, M0t90, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.999, 0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S957" CDS complement(2194806..2195711) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maturation of 16S RNA and assembly of 30S ribosomal subunit GTPase" /protein_id="NP_390407.1" /db_xref="EnsemblGenomes-Gn:BSU25290" /db_xref="EnsemblGenomes-Tr:CAB14458" /db_xref="GOA:P42182" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005662" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030388" /db_xref="SubtiList:BG11188" /db_xref="UniProtKB/Swiss-Prot:P42182" /translation="MTNESFKSGFVSIIGRPNVGKSTFLNRVIGQKIAIMSDKPQTTR NKVQGVLTTGTSQTIFIDTPGIHKPKHKLGDFMMKVAQNTLKEVDLILFMINAEEGYG KGDEFIIEKLQTMSTPVFLIVNKIDKIHPDQLLLLIDEYRKRYPFKEIVPISALEGNN IETLLAQIEAYLPEGPQFYPSDQVTDHPERFIISELIREKVLHLTREEIPHSIAVAIE SIKGQDNGSVHVAATIVVERDSQKGIVIGKKGSLLKEVGKRARADIEALLGSRVYLEL WVKVQKDWRNKMSQLRDFGFKEDEY*" /label="era CDS" gene complement(2194806..2195711) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /label="era gene" CDS complement(2195692..2196102) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /EC_number="3.5.4.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2526291, 8157589, 10217788, 11851403, 22720735, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2526291, 8157589, 10217788, 11851403, 22720735, 25890046; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidine/deoxycytidine deaminase" /protein_id="NP_390408.1" /db_xref="EnsemblGenomes-Gn:BSU25300" /db_xref="EnsemblGenomes-Tr:CAB14459" /db_xref="GOA:P19079" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR006262" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1JTK" /db_xref="PDB:1UWZ" /db_xref="PDB:1UX0" /db_xref="PDB:1UX1" /db_xref="SubtiList:BG10477" /db_xref="UniProtKB/Swiss-Prot:P19079" /translation="MNRQELITEALKARDMAYAPYSKFQVGAALLTKDGKVYRGCNIE NAAYSMCNCAERTALFKAVSEGDTEFQMLAVAADTPGPVSPCGACRQVISELCTKDVI VVLTNLQGQIKEMTVEELLPGAFSSEDLHDERKL*" /label="cdd CDS" gene complement(2195692..2196102) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /label="cdd gene" promotor_-10 complement(2196140..2196159) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2196151) /Source="Nicolas_upshifts" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2196153..2196220) /Source="Nicolas_S_feature" /locus_tag="new_2611388_2611455_c" /HighExp="Oxctl, H2O2, G180, G150, GM 120, S1, G135, Diami, LBGtran, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S958" promotor_-35 complement(2196174..2196177) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2196221..2196592) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /EC_number="2.7.1.66" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12923107, 17535816, 19935659, 28872301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenol kinase" /protein_id="NP_390409.2" /db_xref="EnsemblGenomes-Gn:BSU25310" /db_xref="EnsemblGenomes-Tr:CAB14460" /db_xref="GOA:P19638" /db_xref="InterPro:IPR000829" /db_xref="InterPro:IPR033717" /db_xref="InterPro:IPR036945" /db_xref="SubtiList:BG11040" /db_xref="UniProtKB/Swiss-Prot:P19638" /translation="MDSKDHRNELNRFFKSFVHAGRGIWETARTERNFQFHAAAACAV LICGFLVELSIIEWMIIFLLIGGMFSLELLNTAIEHTVDLITDKHHPLAKAAKDAAAG AVCVFAVISCIIGLLIFLPKL*" /label="unpK CDS" gene complement(2196221..2196592) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /label="unpK gene" CDS complement(2196573..2197046) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16511207, 16818608, 19181801, 20639334, 20807199, 23273979, 23638028, 24511998, 24901994, 28031281; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease involved in 70S ribosomes quality control" /protein_id="NP_390410.2" /db_xref="EnsemblGenomes-Gn:BSU25320" /db_xref="EnsemblGenomes-Tr:CAB14461" /db_xref="GOA:P46347" /db_xref="InterPro:IPR002036" /db_xref="InterPro:IPR020549" /db_xref="InterPro:IPR023091" /db_xref="SubtiList:BG11656" /db_xref="UniProtKB/Swiss-Prot:P46347" /translation="MSLLIDIVDETGSVSEEMLKEVENLLQFAAEREGVQDQAEVSVT IVSNDDIHQINKEYRGKDAPTDVISFALEEEGEGEIEIVGAEMPPVLGDIIISADRTR EQAEEYNHSFKRELGFLAVHGFLHLLGYDHMTKEEEEEMFTKQKELLDAYGLKRS*" /label="rnrY CDS" gene complement(2196573..2197046) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /label="rnrY gene" CDS complement(2197047..2199182) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751502, 26240071, 27378384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751502, 26240071, 27378384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="c-di-AMP-degrading phosphodiesterases" /protein_id="NP_390411.1" /db_xref="EnsemblGenomes-Gn:BSU25330" /db_xref="EnsemblGenomes-Tr:CAB14462" /db_xref="GOA:P46344" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR011621" /db_xref="InterPro:IPR011624" /db_xref="SubtiList:BG11655" /db_xref="UniProtKB/Swiss-Prot:P46344" /translation="MLKKKAKTKSSSKKWSSFKNARSMHVLLYLLLAAIMFALLFVHV KPETLDLDLFSVSDKTIYAPATVEDQKATEEKKQAAEDAVEDQYTLKKEYTDNRIDLV SSIFDSISEVKKSSEEGSKSPSEKSMVKSVKDKLTSDVNDSISEDSIKTLLKADSEDF SFVRDTVITAVNTVMSSEIPSDKLSDAKDKVEKELKSNSIPSKYLGAATEIGRFAIIP NYVFDPKATEAKRQEASDNVQQVQIKQGQVLVEENDLIDREVYRKLELTGLLNNSNLF KPISGLLIMIGLFIATLVYYFEKQKQNLKFKNQSILLFSIITTLLLVIMEVVSLFQKM EYNNIGYLVPIAAGAILIKLLMNERIAILGSIILAICGSMMFNQGVTGTFNYVIGIYY LISGISGVLFLGKHNARSKILQTGLFVAFINMVVVLSLLLIQNTALSGLEIGTLMLMG VVSGFASSVLIIGLMPFFETGFGILSTMRLLELSNPNHPLLRKILTETPGTYHHSVMV ANLSEAACEAVGANGLLARVGAYYHDLGKTKRPQYFIENQMNIDNPHDKLSPQLSKNI IISHTTDGANMLRSYKFPKELVDIAEQHHGTSLLKFFYYKAKEKGDQITEEEFRYPGP KPQSKEAAIISVADSVEAAVRSMHNPNPERIEKLVRGIISDKLQDGQFSECDLTFKEL DTIAKTLCATLKGIFHSRIEYPEATKKVK*" /label="pgpH CDS" gene complement(2197047..2199182) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /label="pgpH gene" promotor_-35 2199026..2199031 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2199046 /Source="Nicolas_upshifts" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2199047..2199065 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2199261..2200220) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12762842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12762842; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="phosphate starvation-induced protein" /protein_id="NP_390412.2" /db_xref="EnsemblGenomes-Gn:BSU25340" /db_xref="EnsemblGenomes-Tr:CAB14476" /db_xref="GOA:P46343" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11337" /db_xref="UniProtKB/Swiss-Prot:P46343" /translation="MTEHLLAMNQKLKNPDEALSLFGNQDSFLKLMEKDLNLNIITRG ETIYVSGDDESFQIADRLLGSLLALIRKGIEISERDVIYAIKMAKKNELEYFESMYEE EITKNAKGKSIRVKTMGQREYVAAMKRNDLVFGIGPAGTGKTYLAVVKAVHALKNGHI KKIILTRPAVEAGESLGFLPGDLKEKVDPYLRPLYDALHDVLGADHTERLMERGIIEI APLAYMRGRTLDDAYVILDEAQNTTPAQMKMFLTRLGFGSKMIITGDVSQIDLPKGVK SGLAVAKEMLKGIDGISMIELDQTDVVRHPLVAKIIEAYDKQN*" /label="phoH CDS" gene complement(2199261..2200220) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /label="phoH gene" downshifts complement(2199276) /Source="Nicolas_upshifts" /id="D1313" /incds=0 /nref=1 /ntot=63 /MaxReadThrough="6.04676" /MaxDrop="4.50442" /score="9.12152318" /energy="-13.1" /TU="U1975,U1976,U1977" /idTUdmin="U1978" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" CDS complement(2200217..2201413) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14523133, 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage IV sporulation protein; putative UDP-glucose-4-epimerase" /protein_id="NP_390413.2" /db_xref="EnsemblGenomes-Gn:BSU25350" /db_xref="EnsemblGenomes-Tr:CAB14477" /db_xref="GOA:P54469" /db_xref="InterPro:IPR010690" /db_xref="SubtiList:BG11654" /db_xref="UniProtKB/Swiss-Prot:P54469" /translation="MKNKWLSFFSGKVQLELTGRGIERLLNECTRQGIPVFHVKKKKE AVSLYIQLQDVHAFRRVRSKFKCKARFINRKGFPFLLLKSKLNIGFTIGFAIFFILLF LLSNMVWKIDVTGAKPETEHQMRQHLNEIGVKKGRLQFLMMSPEKIQKSLTNGIDNIT WVGVDLKGTTIHMKVVEKNEPEKEKYVSPRNIVAKKKATITRMFVQKGQPMAAIHDHV EKGQLLVSGLIGSEDHQQEVASKAEIYGETWYRSEVTVPLETLFNVYTGKVRTKHKLS FGSLAIPIWGMTFKKEELKHPKTEQEKHSLHFLGFKLPVSYVKEQTRESEEALRKYTK EEAVQEGIKLGKQDVEDKIGENGEVKSEKVLHQTVENGKVKLIILYQVIEDIVQTTPI VRETEE*" /label="yqfD CDS" gene complement(2200217..2201413) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /label="yqfD gene" promotor_-10 complement(2200284..2200303) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2200289) /Source="Nicolas_upshifts" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2200317..2200324) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2200364..2200382) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-10" upshifts complement(2200376) /Source="Nicolas_upshifts" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="upshifts" promotor_-35 complement(2200397..2200403) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-35" upshifts complement(2200591) /Source="Nicolas_upshifts" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="upshifts" promotor_-10 complement(2200605..2200616) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-10" promotor_-35 complement(2200631..2200637) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-35" CDS complement(2201432..2201713) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12662922" /codon_start=1 /transl_table=11 /product="conserved sporulation protein of unknown function" /protein_id="NP_390414.1" /db_xref="EnsemblGenomes-Gn:BSU25360" /db_xref="EnsemblGenomes-Tr:CAB14478" /db_xref="InterPro:IPR022476" /db_xref="InterPro:IPR022477" /db_xref="SubtiList:BG11653" /db_xref="UniProtKB/Swiss-Prot:P54468" /translation="MGQRKNRMKAWLTRALEIPPDVMMDLPRITMVGRLHIYIENHRG LLLFSENEVRLMLKQGQCIISGKNFVIKAILPEEILLEGTIDVVRYVES*" /label="yqfC CDS" gene complement(2201432..2201713) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /label="yqfC gene" CDS complement(2201770..2202189) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390415.2" /db_xref="EnsemblGenomes-Gn:BSU25370" /db_xref="EnsemblGenomes-Tr:CAB14479" /db_xref="GOA:P54467" /db_xref="InterPro:IPR016788" /db_xref="SubtiList:BG11652" /db_xref="UniProtKB/Swiss-Prot:P54467" /translation="MEDLLTNPLIIAAIIGIISAIFGKKSKEEKQNSQKRKKPQHVQS ASPQKKQSKEDAPAPIPNRMEQARREAEERRRETARNLKGLERDLAAAKQKTVYTKQK MLQVNKDTVVQGIVLGEVFGPPRAKKPHRTMRPARKN*" /label="yqfB CDS" gene complement(2201770..2202189) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /label="yqfB gene" downshifts complement(2201784) /Source="Nicolas_upshifts" /id="D1314" /incds=0 /nref=232 /ntot=257 /MaxReadThrough="4.55662" /MaxDrop="7.47609" /score="-3.87904232" /energy="-16.8" /TU="U1978" /idTUdmin="U1980" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2202214..2203209) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12501411, 22753055" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12501411, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="flotillin-like protein involved in membrane lipid rafts" /protein_id="NP_390416.1" /db_xref="EnsemblGenomes-Gn:BSU25380" /db_xref="EnsemblGenomes-Tr:CAB14480" /db_xref="GOA:P54466" /db_xref="InterPro:IPR022853" /db_xref="SubtiList:BG11651" /db_xref="UniProtKB/Swiss-Prot:P54466" /translation="MDPSTLMILAIVAVAIIVLAVFFTFVPVMLWISALAAGVKISIF TLVGMRLRRVIPNRVVNPLIKAHKAGLNVGTNQLESHYLAGGNVDRVVNALIAAQRAN IELTFERCAAIDLAGRDVLEAVQMSVNPKVIETPFIAGVAMDGIEVKAKARITVRANI ERLVGGAGEETIVARVGEGIVSTIGSSDNHKKVLENPDMISQTVLGKGLDSGTAFEIL SIDIADVDIGKNIGAILQTDQAEADKNIAQAKAEERRAMAVAQEQEMRARVEEMRAKV VEAEAEVPLAMAEALREGNIGVMDYMNIKNIDADTEMRDSFGKLTKDPSDEDRKS*" /label="floA CDS" gene complement(2202214..2203209) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /label="floA gene" CDS complement(2203231..2204544) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22753055; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound peptidase of unkwnown function" /protein_id="NP_390417.1" /db_xref="EnsemblGenomes-Gn:BSU25390" /db_xref="EnsemblGenomes-Tr:CAB14481" /db_xref="GOA:P54465" /db_xref="InterPro:IPR002810" /db_xref="InterPro:IPR002825" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11650" /db_xref="UniProtKB/Swiss-Prot:P54465" /translation="MLQIKGFRAALLGIFLLSLLGVQLNAKAEKQTVYVIPVEKNVEQ GLASFLSRSLQDAKDAHADHIILDINTPGGLVKSAIDMADLITESEIPVTAYVNKRAL SAGAYIALQADHIYMAPGGKMGAAAIVDGQGNAADQKAQSLWLAEMEDAAVKNNRDPK YALAMADPDIDAKEVGAPKGDLLTLNADKAIEVGYSEGTADNLSTLVKKLGFEKAQIS YAKESFAEKTARWLTNPVIVPILLTIAFLGLTVELFSPGVGLPGTAGLIALLLFFYGH LAAGLAGYETVLLFIAGVILILLEIFLPGGIIGLLGLGAIIASLFLAAGSFTVMAVSL LIASAVSITAFILLTRVLGKRMKFFKKLILNDSTNTESGYVSNQTRTDLMGKVGITFT PLRPSGTVIIDDERLDVVSEGSFTEKDKKVKVIKVEGSRIVVREI*" /label="nfeDA CDS" gene complement(2203231..2204544) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /label="nfeDA gene" promotor_-10 complement(2204580..2204595) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-10" upshifts complement(2204597) /Source="Nicolas_upshifts" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="upshifts" promotor_-35 complement(2204608..2204617) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-35" CDS complement(2204675..2205121) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17284460, 22720735, 25149203" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function with tRNA aminoacid amidase domain" /protein_id="NP_390418.1" /db_xref="EnsemblGenomes-Gn:BSU25400" /db_xref="EnsemblGenomes-Tr:CAB14482" /db_xref="GOA:P54464" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR019004" /db_xref="InterPro:IPR023168" /db_xref="PDB:1NG6" /db_xref="SubtiList:BG11649" /db_xref="UniProtKB/Swiss-Prot:P54464" /translation="MSLLERLNQDMKLYMKNREKDKLTVVRMVKASLQNEAIKLKKDS LTEDEELTVLSRELKQRKDSLQEFSNANRLDLVDKVQKELDILEVYLPEQLSEEELRT IVNETIAEVGASSKADMGKVMGAIMPKVKGKADGSLINKLVSSQLS*" /label="yqeY CDS" gene complement(2204675..2205121) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /label="yqeY gene" downshifts complement(2204688) /Source="Nicolas_upshifts" /id="D1315" /incds=0 /nref=248 /ntot=267 /MaxReadThrough="5.1355" /MaxDrop="8.31948" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1760 /isTUend="FALSE" /label="downshifts" downshifts complement(2204886) /Source="Nicolas_upshifts" /id="D1316" /incds=1 /nref=1 /ntot=34 /MaxReadThrough="8.99916" /MaxDrop="1.9798" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(2205136..2205309) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 22720735, 23002217, 25035996" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 22720735, 23002217, 25035996; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S21" /protein_id="NP_390419.1" /db_xref="EnsemblGenomes-Gn:BSU25410" /db_xref="EnsemblGenomes-Tr:CAB14483" /db_xref="GOA:P21478" /db_xref="InterPro:IPR001911" /db_xref="InterPro:IPR018278" /db_xref="SubtiList:BG11648" /db_xref="UniProtKB/Swiss-Prot:P21478" /translation="MSKTVVRKNESLEDALRRFKRSVSKTGTLQEARKREFYEKPSVK RKKKSEAARKRKF*" /label="rpsU CDS" gene complement(2205136..2205309) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /label="rpsU gene" misc_feature 2205245..2205249 /Source="Nicolas_upshift_promotors" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2205250 /Source="Nicolas_upshifts" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2205370..2205389) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2205385) /Source="Nicolas_upshifts" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2205403..2205410) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2205428..2205433 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2205448 /Source="Nicolas_upshifts" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2205449..2205467 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2205482..2206405 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/anion cotransporter" /protein_id="NP_390420.2" /db_xref="EnsemblGenomes-Gn:BSU25420" /db_xref="EnsemblGenomes-Tr:CAB14484" /db_xref="GOA:P54463" /db_xref="InterPro:IPR003841" /db_xref="InterPro:IPR004633" /db_xref="SubtiList:BG11647" /db_xref="UniProtKB/Swiss-Prot:P54463" /translation="MLILISFTALILFFLAGMNMLRKGLISMAYSKIEERLLLFTDHP LKAFLISIVFTGILQSSSAFMVIVIGFVSAGVLSFKRTIPMILGTNVGSTFTTEFIAI KMDIVIWVLLIGGLLFFLTGRYPLKQLGTSFLGLGIIFFCISGFSHLAGPLTKLKTGA DVLYHVNDSNWSALLIGMVLTAIIHSSSVCIGILMSFMNEGIIGLTQAMSVVLGSNIG TCITAVMAAVSGGYAAKQTAYAHVVFNVLGVALVLPFLTAATGFVEQLSPDPAQKIAH FSLLFNVVTALLFLPLTNLFYRLIHLLIPAK*" /label="yqeW CDS" gene 2205482..2206405 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /label="yqeW gene" CDS complement(2206442..2207797) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA N(6)-threonylcarbamoyladenosine (t(6)A) methylthiotransferase" /protein_id="NP_390421.1" /db_xref="EnsemblGenomes-Gn:BSU25430" /db_xref="EnsemblGenomes-Tr:CAB14485" /db_xref="GOA:P54462" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006467" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR034557" /db_xref="SubtiList:BG11646" /db_xref="UniProtKB/Swiss-Prot:P54462" /translation="MATVAFHTLGCKVNHYETEAIWQLFKEAGYERRDFEQTADVYVI NTCTVTNTGDKKSRQVIRRAIRQNPDGVICVTGCYAQTSPAEIMAIPGVDIVVGTQDR EKMLGYIDQYREERQPINGVSNIMKARVYEELDVPAFTDRTRASLKIQEGCNNFCTFC IIPWARGLLRSRDPEEVIKQAQQLVDAGYKEIVLTGIHTGGYGEDMKDYNFAKLLSEL DTRVEGVKRIRISSIEASQITDEVIEVLDRSDKIVNHLHIPIQSGSNTVLKRMRRKYT MEFFADRLNKLKKALPGLAVTSDVIVGFPGETEEEFMETYNFIKEHKFSELHVFPYSK RTGTPAARMEDQVDENVKNERVHRLIALSDQLAKEYASQYENEVLEIIPEEAFKETEE ENMFVGYTDNYMKVVFKGTEDMIGKIVKVKILKAGYPYNEGQFVRVVEDEITEHMRLS S*" /label="mtaB CDS" gene complement(2206442..2207797) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /label="mtaB gene" downshifts complement(2206448) /Source="Nicolas_upshifts" /id="D1317" /incds=0 /nref=208 /ntot=260 /MaxReadThrough="1.95578" /MaxDrop="6.05381" /score="30.7201786" /energy="-11.3" /TU="NA" /idTUdmin="U1983" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2207797..2208567) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /EC_number="2.1.1.193" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9023197, 10383760, 14517985, 16014871, 16431987, 22925577, 24598751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylase of U1498 in 16S rRNA" /protein_id="NP_390422.1" /db_xref="EnsemblGenomes-Gn:BSU25440" /db_xref="EnsemblGenomes-Tr:CAB14486" /db_xref="GOA:P54461" /db_xref="InterPro:IPR006700" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1VHK" /db_xref="SubtiList:BG11645" /db_xref="UniProtKB/Swiss-Prot:P54461" /translation="MQRYFIELTKQQIEEAPTFSITGEEVHHIVNVMRMNEGDQIICC SQDGFEAKCELQSVSKDKVSCLVIEWTNENRELPIKVYIASGLPKGDKLEWIIQKGTE LGAHAFIPFQAARSVVKLDDKKAKKKRERWTKIAKEAAEQSYRNEVPRVMDVHSFQQL LQRMQDFDKCVVAYEESSKQGEISAFSAIVSSLPKGSSLLIVFGPEGGLTEAEVERLT EQDGVTCGLGPRILRTETAPLYALSAISYQTELLRGDQ*" /label="rsmE CDS" gene complement(2207797..2208567) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /label="rsmE gene" CDS complement(2208590..2209525) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17215866, 18611379; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 methyltransferase" /protein_id="NP_390423.2" /db_xref="EnsemblGenomes-Gn:BSU25450" /db_xref="EnsemblGenomes-Tr:CAB14487" /db_xref="GOA:P54460" /db_xref="InterPro:IPR004498" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11644" /db_xref="UniProtKB/Swiss-Prot:P54460" /translation="MKWSELSIHTTHEAVEPISNILHEAGASGVVIEDPLDLIKEREN VYGEIYQLDPNDYPDEGVIVKAYLPVNSFLGETVDGIKETINNLLLYNIDLGRNHITI SEVNEEEWATAWKKYYHPVKISEKFTIVPTWEEYTPVHTDELIIEMDPGMAFGTGTHP TTVLCIQALERFVQKGDKVIDVGTGSGILSIAAAMLEAESVHAYDLDPVAVESARLNL KLNKVSDIAQVKQNNLLDGIEGEHDVIVANILAEVILRFTSQAYSLLKEGGHFITSGI IGHKKQEVKEALEQAGFTIVEILSMEDWVSIIAKK*" /label="prmA CDS" gene complement(2208590..2209525) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /label="prmA gene" CDS complement(2209550..2210677) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10383760, 10658654, 16385044, 16952052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10383760, 10658654, 16385044, 16952052; Product type f: factor" /codon_start=1 /transl_table=11 /product="co-factor of molecular chaperone" /protein_id="NP_390424.2" /db_xref="EnsemblGenomes-Gn:BSU25460" /db_xref="EnsemblGenomes-Tr:CAB14488" /db_xref="GOA:P17631" /db_xref="InterPro:IPR001305" /db_xref="InterPro:IPR001623" /db_xref="InterPro:IPR002939" /db_xref="InterPro:IPR008971" /db_xref="InterPro:IPR012724" /db_xref="InterPro:IPR018253" /db_xref="InterPro:IPR036410" /db_xref="InterPro:IPR036869" /db_xref="SubtiList:BG10665" /db_xref="UniProtKB/Swiss-Prot:P17631" /translation="MSKRDYYEVLGVSKSASKDEIKKAYRKLSKKYHPDINKEAGSDE KFKEVKEAYETLSDDQKRAHYDQFGHTDPNQGFGGGGFGGGDFGGFGFDDIFSSIFGG GTRRRDPNAPRQGADLQYTMTLSFEDAAFGKETTIEIPREETCETCKGSGAKPGTNPE TCSHCGGSGQLNVEQNTPFGKVVNRRVCHHCEGTGKIIKNKCADCGGKGKIKKRKKIN VTIPAGVDDGQQLRLSGQGEPGINGGPAGDLFVVFHVRAHEFFERDGDDIYCEMPLTF AQAALGDEVEVPTLHGKVKLKIPAGTQTGTKFRLRGKGVQNVRGYGQGDQHIVVRVVT PTNLTDKQKDIIREFAEVSGNLPDEQEMSFFDKVKRAFKGD*" /label="dnaJ CDS" gene complement(2209550..2210677) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /label="dnaJ gene" misc_feature 2210594..2210597 /Source="Nicolas_upshift_promotors" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2210605 /Source="Nicolas_upshifts" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2210678..2210855) /Source="Nicolas_S_feature" /locus_tag="new_2625913_2626090_c" /HighExp="Heat, dia15, H2O2, Diami, G135, G150, G180, LPhT, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.357489" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S959" misc_RNA 2210717..2210807 /gene="surC" /locus_tag="BSU_misc_RNA_79" /product="sporulation-related small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surC RNA" gene 2210717..2210807 /gene="surC" /locus_tag="BSU_misc_RNA_79" /label="surC gene" CDS complement(2210877..2212712) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular chaperone, ATP-dependent" /protein_id="NP_390425.1" /db_xref="EnsemblGenomes-Gn:BSU25470" /db_xref="EnsemblGenomes-Tr:CAB14489" /db_xref="GOA:P17820" /db_xref="InterPro:IPR012725" /db_xref="InterPro:IPR013126" /db_xref="InterPro:IPR018181" /db_xref="InterPro:IPR029047" /db_xref="InterPro:IPR029048" /db_xref="PDB:2FZO" /db_xref="SubtiList:BG10664" /db_xref="UniProtKB/Swiss-Prot:P17820" /translation="MSKVIGIDLGTTNSCVAVLEGGEPKVIANAEGNRTTPSVVAFKN GERQVGEVAKRQSITNPNTIMSIKRHMGTDYKVEIEGKDYTPQEVSAIILQHLKSYAE SYLGETVSKAVITVPAYFNDAERQATKDAGKIAGLEVERIINEPTAAALAYGLDKTDE DQTILVYDLGGGTFDVSILELGDGVFEVRSTAGDNRLGGDDFDQVIIDHLVSEFKKEN GIDLSKDKMALQRLKDAAEKAKKDLSGVSSTQISLPFITAGEAGPLHLELTLTRAKFE ELSSHLVERTMGPVRQALQDAGLSASEIDKVILVGGSTRIPAVQEAIKKETGKEAHKG VNPDEVVALGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSK SQVFSTAADNQTAVDIHVLQGERPMSADNKTLGRFQLTDIPPAPRGVPQIEVSFDIDK NGIVNVRAKDLGTGKEQNITIKSSSGLSDEEIERMVKEAEENADADAKKKEEIEVRNE ADQLVFQTEKTLKDLEGKVDEEQVKKANDAKDALKAAIEKNEFEEIKAKKDELQTIVQ ELSMKLYEEAAKAQQAQGGANAEGKADDNVVDAEYEEVNDDQNKK*" /label="dnaK CDS" gene complement(2210877..2212712) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /label="dnaK gene" downshifts complement(2210900) /Source="Nicolas_upshifts" /id="D1318" /incds=0 /nref=130 /ntot=247 /MaxReadThrough="8.0737" /MaxDrop="4.023" /score="21.9400858" /energy="-13.4" /TU="U1983,U1985" /idTUdmin="U1984" /TUdmin=3565 /isTUend="FALSE" /label="downshifts" CDS complement(2212736..2213299) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nucleotide exchange factor for DnaK activity" /protein_id="NP_390426.1" /db_xref="EnsemblGenomes-Gn:BSU25480" /db_xref="EnsemblGenomes-Tr:CAB14490" /db_xref="GOA:P15874" /db_xref="InterPro:IPR000740" /db_xref="InterPro:IPR009012" /db_xref="InterPro:IPR013805" /db_xref="PDB:2G61" /db_xref="SubtiList:BG10663" /db_xref="UniProtKB/Swiss-Prot:P15874" /translation="MSEEKQTVEQNETEEQEIIEEQAAADEQQEETNESELLQNQINE LQGLLEEKENKLLRVQADFENYKRRSRLEMEASQKYRSQNIVTDLLPALDSFERALQV EADNEQTKSLLQGMEMVHRQLVEALKKEGVEAIEAVGQEFDPNLHQAVMQAEDENYGS NIVVEEMQKGYKLKDRVIRPSMVKVNQ*" /label="grpE CDS" gene complement(2212736..2213299) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /label="grpE gene" S_feature complement(2213300..2213370) /Source="Nicolas_S_feature" /locus_tag="new_2628535_2628605_c" /HighExp="LPhT, dia15, Heat, Etha, Diami, dia5, H2O2, T-0.40H, T0.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S960" CDS complement(2213371..2214402) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10555317, 12082092, 15109714, 16872404, 16585746, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10555317, 12082092, 15109714, 16872404, 16585746, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of heat-shock genes" /protein_id="NP_390427.1" /db_xref="EnsemblGenomes-Gn:BSU25490" /db_xref="EnsemblGenomes-Tr:CAB14491" /db_xref="GOA:P25499" /db_xref="InterPro:IPR002571" /db_xref="InterPro:IPR021153" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10662" /db_xref="UniProtKB/Swiss-Prot:P25499" /translation="MLTNRQLLILQVIINDFIKSAQPVGSRTLSKKDEITFSSATIRN EMADLEELGFIEKTHSSSGRVPSEKGYRYYVDHLLSPVKLTKSDLDQIHSIFKEKIFE LEKTVQKSAQILSDLTNYTSIVLGPKLSENYLKQIQIIPIQPDMAVAILVTNTGHVEN KTINFPTKMDLSDIEKLVNILNDRLSGVPMDELNERIFKEVVMYLRQHIKNYDNILDA LRSTFHSTNHVEKLFFGGKINMLNQPEFHDITRVRSLLSLIEKEQDVLKLVQSPHTGI SIKIGKENDYEEMENCSLITASYSVDQKQIGSIAIIGPTRMNYSRVVSLLQHVTSDLS KALTSLYDE*" /label="hrcA CDS" gene complement(2213371..2214402) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /label="hrcA gene" promotor_-10 complement(2214443..2214462) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2214456) /Source="Nicolas_upshifts" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2214477..2214484) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2214483..2215622) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /EC_number="1.3.98.3" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8757728, 9371469, 10498703, 12196143, 19944166" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8757728, 9371469, 10498703, 12196143, 19944166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_390428.2" /db_xref="EnsemblGenomes-Gn:BSU25500" /db_xref="EnsemblGenomes-Tr:CAB14492" /db_xref="GOA:P54304" /db_xref="InterPro:IPR004559" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010723" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG11395" /db_xref="UniProtKB/Swiss-Prot:P54304" /translation="MKSAYIHIPFCEHICHYCDFNKYFIQSQPVDEYLNALEQEMINT IAKTGQPDLKTIFIGGGTPTSLSEEQLKKLMDMINRVLKPSSDLSEFAVEANPDDLSA EKLKILKEAGVNRLSFGVQTFEDDLLEKIGRVHKQKDVFTSFERAREIGFENISLDLM FGLPGQTLKHLEHSINTALSLDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPPQEQEAE MYEIVMSKMEAHGIHQYEISNFAKAGMESKHNLTYWSNEQYFGFGAGAHGYIGGTRTV NVGPVKHYIDLIAEKGFPYRDTHEVTTEEQIEEEMFLGLRKTAGVSKKRFAEKYGRSL DGLFPSVLKDLAEKGLIHNSESAVYLTHQGKLLGNEVFGAFLGEL*" /label="hemN CDS" gene complement(2214483..2215622) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /label="hemN gene" promotor_-10 complement(2215495..2215506) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-10" upshifts complement(2215499) /Source="Nicolas_upshifts" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="upshifts" promotor_-35 complement(2215520..2215526) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-35" CDS complement(2215675..2217513) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12511492, 17110332, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal elongation factor, GTPase" /protein_id="NP_390429.1" /db_xref="EnsemblGenomes-Gn:BSU25510" /db_xref="EnsemblGenomes-Tr:CAB14493" /db_xref="GOA:P37949" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006297" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR013842" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035654" /db_xref="SubtiList:BG10441" /db_xref="UniProtKB/Swiss-Prot:P37949" /translation="MTDKEKRLERQSRIRNFSIIAHIDHGKSTLADRILEKTSAITQR EMKEQLLDSMDLERERGITIKLNSVQLKYKAKDGEEYIFHLIDTPGHVDFTYEVSRSL AACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPSAEPERVRQEVEDV IGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDPEAPLKALIFDSLYDAYRGVVA YIRVVEGTVKPGQKIKMMATGKEFEVTEVGVFTPKATPTNELTVGDVGFLTASIKNVG DTRVGDTITSAANPAEEALPGYRKLNPMVYCGLYPIDTAKYNDLREALEKLELNDSSL QYEAETSQALGFGFRCGFLGMLHMEIIQERIEREFNIDLITTAPSVIYDVYMTDGEKV VVDNPSNMPDPQKIERVEEPYVKATMMVPNDYVGAVMELCQGKRGNFIDMQYLDANRV SIIYDMPLAEIVYEFFDQLKSSTKGYASFDYELIGYKPSKLVKMDIMLNGEKIDALSF IVHRDYAYERGKVIVEKLKELIPRQQFEVPVQAAIGQKIVARSTIKAMRKNVLAKCYG GDISRKRKLLEKQKEGKRRMKQVGSVEVPQEAFMAVLKMDDSPKKQ*" /label="lepA CDS" gene complement(2215675..2217513) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /label="lepA gene" downshifts complement(2215697) /Source="Nicolas_upshifts" /id="D1319" /incds=0 /nref=15 /ntot=213 /MaxReadThrough="5.2925" /MaxDrop="3.979" /score="5.45344919" /energy="-14" /TU="U1985" /idTUdmin="U1984" /TUdmin="-1232" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2217548..2217567) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2217565) /Source="Nicolas_upshifts" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2217583..2217587) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2217647..2217985) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390430.1" /db_xref="EnsemblGenomes-Gn:BSU25520" /db_xref="EnsemblGenomes-Tr:CAB14494" /db_xref="InterPro:IPR020534" /db_xref="SubtiList:BG10440" /db_xref="UniProtKB/Swiss-Prot:P38425" /translation="MIAYFGKCLLLVTIMFLGVLFGMQQANHGMLSMKGYHDPSLKGA FTLTDGKDNEKEASILGETVTAKDLVEKQKELEKVETFNMFSKAGKALSDTVTNTAQS MYEWIRDMNQ*" /label="yqxA CDS" gene complement(2217647..2217985) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /label="yqxA gene" downshifts complement(2217653) /Source="Nicolas_upshifts" /id="D1320" /incds=0 /nref=11 /ntot=43 /MaxReadThrough="2.553" /MaxDrop="3.8126" /score="5.45344919" /energy="-14" /TU="NA" /idTUdmin="U1986" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2218002..2219207) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17376078, 23834622" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17376078, 23834622; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore autolysin (stage II sporulation)" /protein_id="NP_390431.1" /db_xref="EnsemblGenomes-Gn:BSU25530" /db_xref="EnsemblGenomes-Tr:CAB14495" /db_xref="GOA:P37968" /db_xref="InterPro:IPR010897" /db_xref="SubtiList:BG10439" /db_xref="UniProtKB/Swiss-Prot:P37968" /translation="MRNKRRNRQIVVAVNGGKAVKAIFLFIVSLIVIFVLSGVLTSLR PELRPSSDSFYGIAEELPGDVFAHLLQMENHYFASDLSQTDSSFHLSRLSLKLATSIN LEDPRSFLGRELPGFAQFDTEILLAGQGTDYTNMPAESPPPSKVMEEEREANLAEIEK QQTQSDNAQKDPPKQTTGDKKVVFIYHTHNTESYLPLLKGETDPDMARHSKANVTLVG DMFGQALESQGIGATVNKTDIQSKLNKKGLNYARSYDESRPVVKDALASNKNLQYIID IHRDSRRKKDTTATIKGKSYARVAFVVGKKSKNFEENYKIASELHKLMEKKYPGLSTG VFSKGSPGDNGVYNQDLTDRALLLEFGGVDNNLEELQRAANAAADVFSEMYWDAEKVN AASGETKKQ*" /label="spoIIP CDS" gene complement(2218002..2219207) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /label="spoIIP gene" promotor_-10 complement(2219227..2219245) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2219239) /Source="Nicolas_upshifts" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2219261..2219266) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2219270..2220376) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /EC_number="3.4.24.78" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10666631, 10986255, 12807468, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666631, 10986255, 12807468, 23927687; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protease" /protein_id="NP_390432.1" /db_xref="EnsemblGenomes-Gn:BSU25540" /db_xref="EnsemblGenomes-Tr:CAB14496" /db_xref="GOA:P22322" /db_xref="InterPro:IPR005080" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10438" /db_xref="UniProtKB/Swiss-Prot:P22322" /translation="MKKSELDVNQYLIRTDLAVETKEAMANQQAVPTKEIKGFIEKER DHGGIKIRTVDVTKEGAELSGKKEGRYLTLEAQGIRENDSEMQEKVSAVFAEEFSAFL ENLNISKDASCLIVGLGNWNVTPDALGPMAVENLLVTRHLFKLQPENVQEGYRPVSAF APGVMGITGIETSDIIKGVIEQSKPDFVIAIDALAARAVERVNTTIQISDTGIHPGSG VGNKRKDLSKDTLGVPVIAIGVPTVVDAVTIASDTVDYILKHFGREMKDNRPSRSLVP AGMTFGKKKVLTEDDLPDQKQRQSFLGIVGTLQEDEKRQLIHEVLSPLGHNLMVTPKE VDSFIDDMANVLANGLNTALHEKVSQENKGSYNH*" /label="gpr CDS" gene complement(2219270..2220376) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /label="gpr gene" promotor_-10 complement(2220404..2220415) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2220411) /Source="Nicolas_upshifts" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2220430..2220436) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2220475..2220478 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2220491 /Source="Nicolas_upshifts" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2220494..2220513 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2220505..2220579 /Source="Nicolas_S_feature" /locus_tag="new_2635740_2635814" /HighExp="HiTm, LPhT, UNK1, HiOs, dia5, aero, MG 15, SMM, Lbtran, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S961" CDS 2220580..2220846 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16629673, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16629673, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S20 (BS20)" /protein_id="NP_390433.2" /db_xref="EnsemblGenomes-Gn:BSU25550" /db_xref="EnsemblGenomes-Tr:CAB14497" /db_xref="GOA:P21477" /db_xref="InterPro:IPR002583" /db_xref="InterPro:IPR036510" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11643" /db_xref="UniProtKB/Swiss-Prot:P21477" /translation="MPNIKSAIKRTKTNNERRVHNATIKSAMRTAIKQVEASVANNEA DKAKTALTEAAKRIDKAVKTGLVHKNTAARYKSRLAKKVNGLSA*" /label="rpsT CDS" gene 2220580..2220846 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /label="rpsT gene" downshifts 2220835 /Source="Nicolas_upshifts" /id="D1321" /incds=0 /nref=244 /ntot=274 /MaxReadThrough="2.22204" /MaxDrop="8.54705" /score="33.3621187" /energy="-12.3" /TU="NA" /idTUdmin="U1988" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2220861..2221904) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9434186, 11432857, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9434186, 11432857, 12060778, 12682299, 22333191, 23525462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase clamp loader delta subunit" /protein_id="NP_390434.1" /db_xref="EnsemblGenomes-Gn:BSU25560" /db_xref="EnsemblGenomes-Tr:CAB14498" /db_xref="GOA:P54459" /db_xref="InterPro:IPR005790" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR010372" /db_xref="InterPro:IPR027417" /db_xref="PDB:3ZH9" /db_xref="SubtiList:BG11642" /db_xref="UniProtKB/Swiss-Prot:P54459" /translation="MVFDVWKSLKKGEVHPVYCLYGKETYLLQETVSRIRQTVVDQET KDFNLSVFDLEEDPLDQAIADAETFPFMGERRLVIVKNPYFLTGEKKKEKIEHNVSAL ESYIQSPAPYTVFVLLAPYEKLDERKKLTKALKKHAFMMEAKELNAKETTDFTVNLAK TEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIGDREEITLDDVKMLVARSLEQN IFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAEQGYGQK QIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLL QLLKRNEKNDPHY*" /label="holA CDS" gene complement(2220861..2221904) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /label="holA gene" downshifts complement(2220906) /Source="Nicolas_upshifts" /id="D1322" /incds=0 /nref=14 /ntot=198 /MaxReadThrough="1.76478" /MaxDrop="4.34213" /score="-1.12561483" /energy="-8.1" /TU="NA" /idTUdmin="U1989" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2221933..2221952) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2221944..2222093) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513978.1" /translation="MKNLEAKVTFSVLVIIAFLQAVPGACEQAFNINGEAAVRLPLYY FANSI*" /label="hypothetical protein CDS" gene complement(2221944..2222093) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /label="gene" upshifts complement(2221945) /Source="Nicolas_upshifts" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2221966..2221970) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2221968..2222307) /Source="Nicolas_S_feature" /locus_tag="new_2637203_2637542_c" /HighExp="S8, S6, S7, BT, S5, C30, Pyr, G/S, B36, GM 150" /AntisenseName="yqzM" /AntisenseCor="-2.0369593011890001E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S962" downshifts complement(2222011) /Source="Nicolas_upshifts" /id="D1323" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="5.04584" /MaxDrop="3.298" /score="-1.12561483" /energy="-8.1" /TU="U1991,U1995" /idTUdmin="U1992" /TUdmin=748 /isTUend="FALSE" /label="downshifts" promotor_-35 2222080..2222086 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2222100..2222119 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2222101 /Source="Nicolas_upshifts" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="upshifts" CDS 2222134..2222268 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097762.1" /db_xref="EnsemblGenomes-Gn:BSU25569" /db_xref="EnsemblGenomes-Tr:CAX52662" /db_xref="GOA:C0H453" /db_xref="InterPro:IPR025416" /db_xref="UniProtKB/Swiss-Prot:C0H453" /translation="MNDFEKNVQSKRNDAVDSAVGFVVSFGFFAFLFVMATVIHLVGS *" /label="yqzM CDS" gene 2222134..2222268 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /label="yqzM gene" downshifts 2222262 /Source="Nicolas_upshifts" /id="D1324" /incds=0 /nref=156 /ntot=250 /MaxReadThrough="3.51266" /MaxDrop="6.2258" /score="20.1810918" /energy="-12.1" /TU="U1990" /idTUdmin="U1990" /TUdmin="-465" /isTUend="FALSE" /label="downshifts" CDS complement(2222308..2224638) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12123453, 15661011, 16751195, 17630974, 21397556, 27318187" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123453, 15661011, 16751195, 17630974, 21397556, 27318187; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="DNA channel for uptake in competent cells" /protein_id="NP_390435.1" /db_xref="EnsemblGenomes-Gn:BSU25570" /db_xref="EnsemblGenomes-Tr:CAB14499" /db_xref="GOA:P39695" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004477" /db_xref="InterPro:IPR004797" /db_xref="InterPro:IPR025405" /db_xref="InterPro:IPR035681" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10482" /db_xref="UniProtKB/Swiss-Prot:P39695" /translation="MRNSRLLLPMAAASATAGITAAAYFPAIFLFILFLLIILIKTRH AFLIIVCFFSFILFFVLYAVTDSQNVSSYRQGTYQFKAVIDTIPKIDGDRMSMMVETP DKEKWAAAYRIQSAGEKEQLLYIEPGMSCELTGTLEEPNHATVPGAFDYNEYLYRQHI HWNYSVTSIQNCSEPENFKYKVLSLRKHIISFTNSLLPPDSTGIVQALTVGDRFYVED EVLTAYQKLGVVHLLAISGLHVGILTAGLFYIMIRLGITREKASILLLLFLPLYVMLT GAAPSVLRAALMSGVYLAGSLVKWRVRSATAICLSYIVLLLFNPYHLFEAGFQLSFAV SFSLILSSSIFQQVKTSLGQLTIVSLIAQLGSLPILLYHFHQFSIISVPMNMLMVPFY TFCILPGAVAGVLLLSLSASFGRLFFSWFDLLISWINRLITNIADVDVFTIMIAHPAP VLLFLFTVTIILLLMAIEKRSLSQLMVTGGICCTVMFLLFIYPCLSSEGEVDMIDIGQ GDSMFVGAPHQRGRVLIDTGGTLSYSSEPWREKQHPFSLGEKVLIPFLTAKGIKQLDA LILTHADQDHIGEAEILLKHHKVKRLVIPKGFVSEPKDEKVLQAAREEGVAIEEVKRG DVLQIKDLQFHVLSPEAPDPASKNNSSLVLWMETGGMSWILTGDLEKEGEQEVMNVFP NIKADVLKVGHHGSKGSTGEEFIQQLQPKTAIISAGKNNRYHHPHQKVLQLLQRHSIR VLRTDQNGTIQYRYKNRVGTFSVYPPYDTSDITETN*" /label="comEC CDS" gene complement(2222308..2224638) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /label="comEC gene" promotor_-10 complement(2222325..2222344) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2222341) /Source="Nicolas_upshifts" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2222358..2222367) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2224642..2225211) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /EC_number="3.5.4.12" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7768800, 26416910; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="dCMP deaminase associated to DNA transport (competence)" /protein_id="NP_390436.1" /db_xref="EnsemblGenomes-Gn:BSU25580" /db_xref="EnsemblGenomes-Tr:CAB14500" /db_xref="GOA:P32393" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR013404" /db_xref="InterPro:IPR015517" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR016473" /db_xref="InterPro:IPR035105" /db_xref="SubtiList:BG10481" /db_xref="UniProtKB/Swiss-Prot:P32393" /translation="MERISWNQYFMAQSHLLALRSTCPRLSVGATIVRDKRMIAGGYN GSIAGGVHCADEGCLMIDDHCARTIHAEMNAILQCSKFGVPTDGAEIYVTHYPCIQCC KSIIQAGIKTVYYAEDYKTHPYAQELFEQAGVTVEQVELDEMIVDLKNREKLSFVAGL IGKLADAGLAEEELKKIHEQANTLFTSYV*" /label="comEB CDS" gene complement(2224642..2225211) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /label="comEB gene" promotor_-10 complement(2225238..2225257) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2225248) /Source="Nicolas_upshifts" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2225272..2225279) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2225278..2225895) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16751195, 21278288, 22398145, 25727469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751195, 21278288, 22398145, 25727469; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane bound high-affinity DNA-binding receptor" /protein_id="NP_390437.1" /db_xref="EnsemblGenomes-Gn:BSU25590" /db_xref="EnsemblGenomes-Tr:CAB14501" /db_xref="GOA:P39694" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004509" /db_xref="InterPro:IPR004787" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR019554" /db_xref="SubtiList:BG10480" /db_xref="UniProtKB/Swiss-Prot:P39694" /translation="MNWLNQHKKAIILAASAAVFTAIMIFLATGKNKEPVKQAVPTET ENTVVKQEANNDESNETIVIDIKGAVQHPGVYEMRTGDRVSQAIEKAGGTSEQADEAQ VNLAEILQDGTVVYIPKKGEETAVQQGGGGSVQSDGGKGALVNINTATLEELQGISGV GPSKAEAIIAYREENGRFQTIEDITKVSGIGEKSFEKIKSSITVK*" /label="comEA CDS" gene complement(2225278..2225895) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /label="comEA gene" promotor_-35 2225916..2225921 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2225933 /Source="Nicolas_upshifts" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2225937..2225955 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2225956..2225970) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2225958) /Source="Nicolas_upshifts" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2225960..2226807) /Source="Nicolas_S_feature" /locus_tag="new_2641195_2642042_c" /HighExp="C30, T0.30H, T-2.40H, GM 150, T1.30H, T-0.40H, T-1.10H, T-1.40H, T1.0H, T0.0H" /AntisenseName="comER" /AntisenseCor="-8.2389039371154299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S963" promotor_-35 complement(2225979..2225983) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2225979..2226800 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /EC_number="1.5.1.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7968523, 11418582, 27446060, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrroline-5'-carboxylate reductase" /protein_id="NP_390438.1" /db_xref="EnsemblGenomes-Gn:BSU25600" /db_xref="EnsemblGenomes-Tr:CAB14502" /db_xref="GOA:P39696" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10479" /db_xref="UniProtKB/Swiss-Prot:P39696" /translation="MKIGFIGTGNMGTILIESFIESKAADPSNMTITNRTIEKALHIK NRYNSINVTESLEKLVSENEMIFICVKPLDIYPLLARALPYLRKDHILISITSPVQTE QLEQYVPCQVARVIPSITNRALAGVSLVTFGTSCGESAKAKINELMQHISHPLQIESD ITRVASDIVSCGPAFMSYLIQRFIDAAVSETSVSKQDAILMCKEMLVGMGKLLETELY TLPALQEKVCVKGGVTGEGIKALESGVQDMFHRVFQNTHMKYEEDISAVKKQFHV*" /label="comER CDS" gene 2225979..2226800 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /label="comER gene" promotor_-10 complement(2226795..2226814) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2226801..2226881 /Source="Nicolas_S_feature" /locus_tag="new_2642036_2642116" /HighExp="S4, S5, S3, S6, S7, B36, Pyr, G/S, S8, BT" /AntisenseName="yqeM" /AntisenseCor="-0.52267300854840604" /AntisenseRegPval="-19.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S964" upshifts complement(2226808) /Source="Nicolas_upshifts" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2226828..2226835) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2226841 /Source="Nicolas_upshifts" /id="D1325" /incds=0 /nref=45 /ntot=64 /MaxReadThrough="2.4803" /MaxDrop="5.1403" /score="7.09525061" /energy="-10.5" /TU="NA" /idTUdmin="U1993" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2226866..2227609) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390439.1" /db_xref="EnsemblGenomes-Gn:BSU25610" /db_xref="EnsemblGenomes-Tr:CAB14503" /db_xref="GOA:P54458" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11641" /db_xref="UniProtKB/Swiss-Prot:P54458" /translation="MIYQGFASVYDELMSHAPYDQWTKWIEASLPEKGRILDLACGTG EISIRLAEKGFEVTGIDLSEEMLSFAQQKVSSSQPILFLQQDMREITGFDGQFDAVVI CCDSLNYLKTKNDVIETFKSVFRVLKPEGILLFDVHSSFKIAEVFPDSTFADQDEDIS YIWQSFAGSDELSVIHDMSFFVWNGEAYDRFDETHEQRTFPVEEYEEMLKNCGFQLHR VTADFTDTEPSAQSERLFFKAQKSKTIVS*" /label="yqeM CDS" gene complement(2226866..2227609) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /label="yqeM gene" downshifts complement(2226896) /Source="Nicolas_upshifts" /id="D1326" /incds=0 /nref=144 /ntot=230 /MaxReadThrough="1.41467" /MaxDrop="5.51802" /score="7.9251293" /energy="-10.5" /TU="NA" /idTUdmin="U1996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2227606..2227962) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 16980477, 22238375, 22238376, 22829778, 26299947; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal silencing factor" /protein_id="NP_390440.1" /db_xref="EnsemblGenomes-Gn:BSU25620" /db_xref="EnsemblGenomes-Tr:CAB14504" /db_xref="GOA:P54457" /db_xref="InterPro:IPR004394" /db_xref="SubtiList:BG11640" /db_xref="UniProtKB/Swiss-Prot:P54457" /translation="MNQKSILKIAAAACDDKRAEDILALDMEGISLVADYFLICHGNS DKQVQAIAREIKDQADENGIQVKKMEGFDEARWVLVDLGDVVVHVFHKDERSYYNLEK LWGDAPLADLDFGMNQ*" /label="rsfS CDS" gene complement(2227606..2227962) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /label="rsfS gene" CDS complement(2227980..2228540) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390441.1" /db_xref="EnsemblGenomes-Gn:BSU25630" /db_xref="EnsemblGenomes-Tr:CAB14505" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR005249" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11639" /db_xref="UniProtKB/Swiss-Prot:P54456" /translation="MNREEALACVKQQLTEHRYIHTVGVMNTAIELAERFGADSKKAE IAAIFHDYAKFRPKEEMKQIIAREKMPAHLLDHNPELWHAPVGAYLVQREAGVQDEDI LDAIRYHTSGRPGMTLLEKVIYVADYIEPNRAFPGVDEVRKLAETDLNQALIQSIKNT MVFLMKKNQPVFPDTFLTYNWLVSGS*" /label="yqeK CDS" gene complement(2227980..2228540) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /label="yqeK gene" CDS complement(2228530..2229099) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /EC_number="2.7.7.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11704676, 12682299, 19716475, 23204464, 25631047; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide adenylyltransferase" /protein_id="NP_390442.1" /db_xref="EnsemblGenomes-Gn:BSU25640" /db_xref="EnsemblGenomes-Tr:CAB14506" /db_xref="GOA:P54455" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR005248" /db_xref="InterPro:IPR014729" /db_xref="PDB:1KAM" /db_xref="PDB:1KAQ" /db_xref="SubtiList:BG11638" /db_xref="UniProtKB/Swiss-Prot:P54455" /translation="MKKIGIFGGTFDPPHNGHLLMANEVLYQAGLDEIWFMPNQIPPH KQNEDYTDSFHRVEMLKLAIQSNPSFKLELVEMEREGPSYTFDTVSLLKQRYPNDQLF FIIGADMIEYLPKWYKLDELLNLIQFIGVKRPGFHVETPYPLLFADVPEFEVSSTMIR ERFKSKKPTDYLIPDKVKKYVEENGLYES*" /label="nadD CDS" gene complement(2228530..2229099) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /label="nadD gene" CDS complement(2229111..2229401) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 17005971, 17105995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 17005971, 17105995; Product type f: factor" /codon_start=1 /transl_table=11 /product="50S RNA-binding protein" /protein_id="NP_390443.1" /db_xref="EnsemblGenomes-Gn:BSU25650" /db_xref="EnsemblGenomes-Tr:CAB14507" /db_xref="GOA:P54454" /db_xref="InterPro:IPR001890" /db_xref="InterPro:IPR017924" /db_xref="InterPro:IPR035920" /db_xref="SubtiList:BG11637" /db_xref="UniProtKB/Swiss-Prot:P54454" /translation="MLTGKQKRFLRSKAHHLTPIFQVGKGGVNDNMIKQIAEALEARE LIKVSVLQNCEEDKNDVAEALVKGSRSQLVQTIGNTIVLYKESKENKQIELP*" /label="yqeI CDS" gene complement(2229111..2229401) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /label="yqeI gene" CDS complement(2229395..2230237) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /EC_number="1.1.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2104604, 12906820, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate 5-dehydrogenase" /protein_id="NP_390444.2" /db_xref="EnsemblGenomes-Gn:BSU25660" /db_xref="EnsemblGenomes-Tr:CAB14508" /db_xref="GOA:P54374" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR011342" /db_xref="InterPro:IPR013708" /db_xref="InterPro:IPR022893" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11522" /db_xref="UniProtKB/Swiss-Prot:P54374" /translation="MKKLYGVIGNPIGHSMSPDIHNASLKDLGLDGHYHAFKVEENDL EDAVKGIRALGVQGINVTVPHKVSIMDYLDHIDESAKVLGAVNTVRREGDKLVGYNTD GEGFVKSLMKVLDKPISELSFLMIGAGGAARAIFTTIVRNTPKKFDICNRTLEKAKRL TEATPSFHNKEVLSIKEAEERLEQYDVIIHTTSVGMYPNVDDVPLSLQRAASSAVVCD IVYNPIQTALLKEASQKGLKTLDGVGMFVEQAALSFQLWTGQEPNIEKMRSIVIGKLG GTEC*" /label="aroE CDS" gene complement(2229395..2230237) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /label="aroE gene" downshifts 2230229 /Source="Nicolas_upshifts" /id="D1327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="0.240279999999999" /MaxDrop="3.04009" /score="0.0642154872" /energy="-17" /TU="NA" /idTUdmin="U1993" /TUdmin=3388 /isTUend="FALSE" /label="downshifts" CDS complement(2230255..2231355) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent GTPase involved in ribosome 30S assembly" /protein_id="NP_390445.1" /db_xref="EnsemblGenomes-Gn:BSU25670" /db_xref="EnsemblGenomes-Tr:CAB14509" /db_xref="GOA:P54453" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019988" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="SubtiList:BG11636" /db_xref="UniProtKB/Swiss-Prot:P54453" /translation="MEKVVCIGCGVTIQTEDKTGLGYAPPASLTKENVICQRCFRLKN YNEIQDVSLTDDDFLNILHGIGETDSLVVKIVDIFDFNGSWINGLQRLVGGNPILLVG NKADILPKSLKRERLIQWMKREAKELGLKPVDVFLVSAGRGQGIREVIDAIEHYRNGK DVYVVGCTNVGKSTFINRIIKEVSGEEDIITTSQFPGTTLDAIEIPLDDGSSLYDTPG IINNHQMAHYVNKKDLKILSPKKELKPRTFQLNDQQTLYFGGLARFDYVSGERSPFIC YMPNELMIHRTKLENADALYEKHAGELLTPPGKDEMDEFPELVAHTFTIKDKKTDIVF SGLGWVTVHDADKKVTAYAPKGVHVFVRRSLI*" /label="rgpH CDS" gene complement(2230255..2231355) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /label="rgpH gene" CDS complement(2231359..2231877) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase (active on GMP and Glc-6-P)" /protein_id="NP_390446.1" /db_xref="EnsemblGenomes-Gn:BSU25680" /db_xref="EnsemblGenomes-Tr:CAB14510" /db_xref="GOA:P54452" /db_xref="InterPro:IPR006356" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR006549" /db_xref="InterPro:IPR010021" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11635" /db_xref="UniProtKB/Swiss-Prot:P54452" /translation="MLKKFFLPDEFVKNIFHITPEKLKERNVKGIITDLDNTLVEWDR PNATPRLIEWFEEMKEHGIKVTIVSNNNERRVKLFSEPLGIPFIYKARKPMGKAFNRA VRNMELKKEDCVVIGDQLLTDVLGGNRNGYHTILVVPVASSDGFITRFNRQVERRILS ALKRKGHIQWEE*" /label="yqeG CDS" gene complement(2231359..2231877) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /label="yqeG gene" promotor_-10 complement(2231787..2231804) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2231801) /Source="Nicolas_upshifts" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2231820..2231823) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2231878..2232439) /Source="Nicolas_S_feature" /locus_tag="new_2647113_2647674_c" /HighExp="G135, G180, G150, Paraq, Oxctl, C30, Heat, HPh, BMM, LPh" /AntisenseName="sda" /AntisenseCor="-8.6107693225382295E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S965" downshifts complement(2231911) /Source="Nicolas_upshifts" /id="D1328" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="6.83118" /MaxDrop="5.26138" /score="9.20556883" /energy="-8.6" /TU="U1998" /idTUdmin="U1999" /TUdmin=616 /isTUend="FALSE" /label="downshifts" promotor_-35 2232102..2232109 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2232120..2232220 /Source="Nicolas_S_feature" /locus_tag="new_2647355_2647455" /HighExp="T3.0H, T-0.40H, MG 150, T5.0H, T-1.40H, T4.0H, T2.30H, T0.0H, T3.30H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S966" promotor_-10 2232120..2232139 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2232120 /Source="Nicolas_upshifts" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(2232170..2232428) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /product="antisense RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sdaM RNA" gene complement(2232170..2232428) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /label="sdaM gene" CDS 2232221..2232379 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15023339, 16796683, 19040634, 22720735, 28752667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023339, 16796683, 19040634, 22720735, 28752667; Product type f: factor" /codon_start=1 /transl_table=11 /product="check point factor coupling initiation of sporulation and replication initiation" /protein_id="YP_054588.1" /db_xref="EnsemblGenomes-Gn:BSU25690" /db_xref="EnsemblGenomes-Tr:CAE01463" /db_xref="GOA:Q7WY62" /db_xref="InterPro:IPR015064" /db_xref="InterPro:IPR036916" /db_xref="PDB:1PV0" /db_xref="PDB:3FYR" /db_xref="SubtiList:BG14183" /db_xref="UniProtKB/Swiss-Prot:Q7WY62" /translation="MNWVPSMRKLSDELLIESYFKATEMNLNRDFIELIENEIKRRSL GHIISVSS*" /label="sda CDS" gene 2232221..2232379 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /label="sda gene" S_feature 2232380..2232626 /Source="Nicolas_S_feature" /locus_tag="new_2647615_2647861" /HighExp="Cold, T-0.40H, MG 150, T5.0H, T4.0H, C30, T2.30H, M9-tran, S2, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S967" promotor_-10 complement(2232427..2232446) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2232438) /Source="Nicolas_upshifts" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2232462..2232466) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2232490..2232637) /Source="Nicolas_S_feature" /locus_tag="new_2647725_2647872_c" /HighExp="S8, S7, S6, Etha, LBGstat, T0.30H, Salt, BT, LPhT, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99948400000000004" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S968" downshifts complement(2232527) /Source="Nicolas_upshifts" /id="D1329" /incds=0 /nref=12 /ntot=92 /MaxReadThrough="2.70676" /MaxDrop="4.386" /score="9.20556883" /energy="-8.6" /TU="NA" /idTUdmin="U1999" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2232583 /Source="Nicolas_upshifts" /id="D1330" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="5.36291" /MaxDrop="2.1106" /score="10.3636587" /energy="-6.2" /TU="U1997" /idTUdmin="U1997" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 2232628..>2232705 /Source="Nicolas_S_feature" /locus_tag="new_2647863_2648916" /HighExp="T-0.40H, Cold, M40t90, T0.0H, C30, Glucon, S2, T1.30H, T2.30H, T2.0H" /AntisenseName="yqeF" /AntisenseCor="-0.39616310996746001" /AntisenseRegPval="-10.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S969" promotor_-10 complement(2232632..2232651) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2232637) /Source="Nicolas_upshifts" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2232664..2232673) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(2232705,2232707) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_003" N_region 2232706 /note="inserted C residue" /created_by="User" /modified_by="User" /label="IIG_Bs27_003" S_feature <2232707..2233149 /Source="Nicolas_S_feature" /locus_tag="new_2701783_2703117" /HighExp="S8, S6, S7, S5, S4, BT, B36, dia15, C30, H2O2" /AntisenseName="psiE" /AntisenseCor="0.376363934894826" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="0.117191" /TUshortSig="Sig-" /TUshortPSig="0.218" /TUlongSig="NA" /TUlongPSig="NA" /label="S984" CDS complement(2232720..2233136) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12897016, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="phosphate starvation inducible protein" /protein_id="NP_390518.2" /db_xref="EnsemblGenomes-Gn:BSU26410" /db_xref="EnsemblGenomes-Tr:CAB14582" /db_xref="GOA:P54445" /db_xref="InterPro:IPR009315" /db_xref="InterPro:IPR020948" /db_xref="SubtiList:BG11784" /db_xref="UniProtKB/Swiss-Prot:P54445" /translation="MRFSNKFKKVPYLLQALLNVCLFFLALALSALLISETWYIVLFV YKSLFNKVDSYYEMLGELLIFFMYFEFIALIIKYFKSDFHFPLRYFIYIGITAVIRLI IIDHDQAISTFWWAMAILAMICGFFIANRRNSVVEH*" /label="psiE CDS" gene complement(2232720..2233136) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /label="psiE gene" CDS complement(2233182..2234480) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YrkP]" /protein_id="NP_390519.1" /db_xref="EnsemblGenomes-Gn:BSU26420" /db_xref="EnsemblGenomes-Tr:CAB14583" /db_xref="GOA:P54444" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11783" /db_xref="UniProtKB/Swiss-Prot:P54444" /translation="MAHLKFTLTKKLALLIMVAAIVSGVIFLTLQKITDDLIEGYLSS EEYYHEESARYIQKFSKYVSENELSTSDRKAFGEWVKKENYINLTIFKDQELQYDSIY SESDYGKEKLTQYAQNHSHPVKFSDGEGRVIIDGFYSSRYYDLAFALDLLGATLIFLI IVLFGIRQSLRYLKTIHQEIHILEGGELDYEMTIKGHDELAMIAKSIEDLRKAFLDKL KAIEELQAESRSLVTEMSHDMRTPLTSLIMNLEFAKKEGGEAGASKDRYVANAYGKAL QLKSLSDNLFAYFLLNKEYEADLETVAVKEVIYDLISDQIAILHQEHFRVHISGELPE TYINVNLEELGRVFDNVMSNLLKYADPEEKISITFVSDQEIFEIHVSNTIKLADITPE SNGLGERSIARMMSRMQGQFHSIQKNSKYYIVLRFWNTKM*" /label="yrkQ CDS" gene complement(2233182..2234480) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /label="yrkQ gene" CDS complement(2234467..2235162) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18175906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18175906; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YrkQ]" /protein_id="NP_390520.1" /db_xref="EnsemblGenomes-Gn:BSU26430" /db_xref="EnsemblGenomes-Tr:CAB14584" /db_xref="GOA:P54443" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11782" /db_xref="UniProtKB/Swiss-Prot:P54443" /translation="MAYRILVVEDDEDIGDLLEESLTRAGYEVLRAKDGKRALQLVND SLDLVILDIMMPGISGIETCQHIRKSSNVPILFLTARSSTLDKTEGLLAGGDDYMTKP FSEEELHARVIAQLRRYTIYQEKKEQEETFLIGGKLRVSEEFNEVWKEEKQIKLSDLE YRILKLLMNKRNKIFSAQNIYESVWGQPYFYCSNNTVMVHIRKLRSKIEDDPARPVYI KTEWGRGYRFGAS*" /label="yrkP CDS" gene complement(2234467..2235162) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /label="yrkP gene" misc_feature complement(2235228..2235245) /Source="Nicolas_upshift_promotors" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2235237) /Source="Nicolas_upshifts" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2235323..2235329 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2235336..2235354 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2235351 /Source="Nicolas_upshifts" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2235430..2236647 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390521.1" /db_xref="EnsemblGenomes-Gn:BSU26440" /db_xref="EnsemblGenomes-Tr:CAB14585" /db_xref="GOA:P54442" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11781" /db_xref="UniProtKB/Swiss-Prot:P54442" /translation="MIVQKEGRGQPVSLRERVHFLDIVRGFALLGIIIVNYFLIVDSV KGFEMASDDVLHKLVSWFAEGKFVTLFSFLFGVGFMIFMDRAAQKVESPNKLFARRLS ILLGFGILHITFVWVGDILAFYAVSGFLLLAFYKRTAKTVLRWIIALIVFQFLTPVFT MLYNVINTAGSKNPNFSEFTLFSHSSLTYMESISTRWTDMVTMAAGSFSMIYSMFLMF LLGVYFVKMEFFKDMEAKKPIWKRIWIISTIAFLITQSSILLDMFNLSENMLWKDISS VLGQNGGLTGSMFYMSTFAMLFLYLPQLRGPMMIFTKVGRMSLTCYLLHSIIGTVLFL RYGFGLADHIQSAGTFMFSLAVYFVLMSFSTLWLKRFRYGPMELVWRKLTYGKVNGSP KATPLHSEKSIQK*" /label="yrkO CDS" gene 2235430..2236647 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /label="yrkO gene" promotor_-35 2235889..2235896 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2235911..2235930 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2235927 /Source="Nicolas_upshifts" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2236566..2236814 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513983.1" /translation="MAQADVRQSKRESQSNSAAFGKIYSEITPLHRLHDFKLVLLNEA GIKRTDLIYGLVIFISFRLLWANKSTRVYSMCIAHDRI*" /label="hypothetical protein CDS" gene 2236566..2236814 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /label="gene" S_feature complement(2236743..2237790) /Source="Nicolas_S_feature" /locus_tag="new_2706711_2707758_c" /HighExp="Diami, C30, dia15, dia5, Lbstat, S8, C90, G180, H2O2, G135" /AntisenseName="yrkN" /AntisenseCor="0.40539464433869998" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S985" CDS 2237159..2237716 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /EC_number="2.3.-.-" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390522.1" /db_xref="EnsemblGenomes-Gn:BSU26450" /db_xref="EnsemblGenomes-Tr:CAB14586" /db_xref="GOA:P54441" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11780" /db_xref="UniProtKB/Swiss-Prot:P54441" /translation="MKTKNEPKVILELAKESDLPEFQKKLQEAFAIAVIETFGDCEDG PIPSDNDVQESFNAPGAVVYHILQDGKNVGGAVVRINSQTNHNSLDLFYVSPEYHSQG IGLSAWKAIEAQYPDTVLWETVTPYFEKRNINFYVNKCGFHIVEFYNEHHSNPHMHRN GREDDKPLLNDDDFFRFVKIMKKKD*" /label="yrkN CDS" gene 2237159..2237716 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /label="yrkN gene" S_feature 2237717..2237839 /Source="Nicolas_S_feature" /locus_tag="new_2707685_2707807" /HighExp="S8, Sw, C30, S7, BC, C90, Lbstat, Mal, LoTm, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S986" S_feature complement(2237792..2238206) /Source="Nicolas_S_feature" /locus_tag="new_2707760_2708174_c" /HighExp="M0t90, M40t90, Lbstat, dia5, LPhT, dia15, M9-stat, Lbtran, C90, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S987" downshifts complement(2237835) /Source="Nicolas_upshifts" /id="D1360" /incds=0 /nref=81 /ntot=255 /MaxReadThrough="5.45539" /MaxDrop="5.6563" /score="-3.35079978" /energy="-23.7" /TU="U2041,U2042,U2044,U2045" /idTUdmin="U2042" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" CDS complement(2238207..2238731) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /EC_number="1.6.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase" /protein_id="NP_390524.2" /db_xref="EnsemblGenomes-Gn:BSU26470" /db_xref="EnsemblGenomes-Tr:CAB14588" /db_xref="GOA:P54439" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11778" /db_xref="UniProtKB/Swiss-Prot:P54439" /translation="MKTLVIVIHPNLETSVVNKTWMNRLKQEKDITVHDLYGEYPNFI IDVEKEQQLLLDHERIVFQFPMYWYSSPALLKQWEDDVLTHGWAYGTGGTKLHGKELL LAISLGAQESDYQAGGEYNITISELIRPFQVTANYIGMRFLPAFTQYGTLHLSKEDVK NSAERLVDYLKAEH*" /label="yrkL CDS" gene complement(2238207..2238731) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /label="yrkL gene" promotor_-35 2238579..2238586 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2238597..2238616 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2238611 /Source="Nicolas_upshifts" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2238732..2238819) /Source="Nicolas_S_feature" /locus_tag="new_2708700_2708787_c" /HighExp="dia5, Etha, dia15, M9-stat, M0t90, Lbtran, Diami, C90, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S988" promotor_-10 complement(2238814..2238833) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2238819) /Source="Nicolas_upshifts" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2238821..>2238957) /Source="Nicolas_S_feature" /locus_tag="new_2708789_2708942_c" /HighExp="M0t90, M9-stat, Lbstat, M40t90, T1.30H, C90, Lbtran, T0.30H, dia15, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S989" promotor_-35 complement(2238848..2238855) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(2238957,2238964) /created_by="User" /note="deletion occured in betwen marked nucleotides " /modified_by="User" /label="IIG_Bs12" N_region 2238958..2238963 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs12" CDS complement(2239016..2239546) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11700344, 15019740, 17675383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11700344, 15019740, 17675383; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma-Z)" /protein_id="NP_390561.1" /db_xref="EnsemblGenomes-Gn:BSU26840" /db_xref="EnsemblGenomes-Tr:CAB14625" /db_xref="GOA:O05409" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014304" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11976" /db_xref="UniProtKB/Swiss-Prot:O05409" /translation="MNIEDLWDQFHQPLKTYISHRVNDQSIVDDLLQIVFMKIQVHLP NLIDEQKIDSWIYRITRNTIIDFYRTKKTSEILPDVLHFNDSAEEENFTKEATVCIRS TIKRLPEKYREALELTDFQGLSQKELSEKLGISYSGAKSRVQRGRGKLKQLLEGCCHI EADRYGNIVDFRILKE*" /label="sigZ CDS" gene complement(2239016..2239546) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /label="sigZ gene" promotor_-10 complement(2239592..2239611) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2239615) /Source="Nicolas_upshifts" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2239625..2239632) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2239681..2240661 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23990306, 25326299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_390562.2" /db_xref="EnsemblGenomes-Gn:BSU26850" /db_xref="EnsemblGenomes-Tr:CAB14626" /db_xref="GOA:O05408" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG12309" /db_xref="UniProtKB/Swiss-Prot:O05408" /translation="MEYTYLGRTGLRVSRLCLGTMNFGVDTDEKTAFRIMDEALDNGI QFFDTANIYGWGKNAGLTESIIGKWFAQGGQRREKVVLATKVYEPISDPNDGPNDMRG LSLYKIRRHLEGSLKRLQTDHIELYQMHHIDRRTPWDEIWEAFETQVRSGKVDYIGSS NFAGWHLVKAQAEAEKRRFMGLVTEQHKYSLLERTAEMEVLPAARDLGLGVVAWSPLA GGLLGGKALKSNAGTRTAKRADLIEKHRLQLEKFSDLCKELGEKEANVALAWVLANPV LTAPIIGPRTVEQLRDTIKAVEISLDKEILRMLNDIFPGPGGETPEAYAW*" /label="yrpG CDS" gene 2239681..2240661 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /label="yrpG gene" CDS complement(2240935..2242251) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053381, 11566984, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative citrate transporter" /protein_id="NP_390563.1" /db_xref="EnsemblGenomes-Gn:BSU26860" /db_xref="EnsemblGenomes-Tr:CAB14627" /db_xref="GOA:O05407" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG12279" /db_xref="UniProtKB/Swiss-Prot:O05407" /translation="MLTILGFSMVTVFTILIMTKKVSPIVALTITPIVFALIGGFGKG IGDMILEGIQTVASSAALLLFAILFFGILIDAGLFDPLIEKILSIVKGDPVKIAIGSA VLAMLIALDGDGTTTYMITVSAMLPLYKRIGMNPMVMATLAMLSLSIVSGMTPWGGPA TRAISVLGLDPSDFFVPLLPTMLGGIACVIFLAFLMGRKERNRIGIVQLEPRHITKDS SQSYMAATLESEQLKRPRLIYLNLFLVISIMVFIVLGTKHPSVLFLIGFVLALTINYP NVKMQKERIAEHSGNAITVVLLVFSAGVFAGILSGTKMVDAIAGSLISIIPSSMGGFF PVIVALTSIPFTFVLSNDAYYFGMVPIFAEAASAYGIEPVEIARASIMGQPVHLMSPL VASTVLLVSMLKMDLGSFQRFAVKWAVITSLVITLLAIITGAITIL*" /label="yraO CDS" gene complement(2240935..2242251) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /label="yraO gene" S_feature complement(2242252..2242365) /Source="Nicolas_S_feature" /locus_tag="new_2745480_2745593_c" /HighExp="Lbtran, M40t90, Lbstat, HiTm, Mal, Gly, M0t90, S1, T1.0H, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1012" CDS complement(2242366..2243235) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (probes citrate or citrate-related metabolite)" /protein_id="NP_390564.1" /db_xref="EnsemblGenomes-Gn:BSU26870" /db_xref="EnsemblGenomes-Tr:CAB14628" /db_xref="GOA:O07906" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12278" /db_xref="UniProtKB/Swiss-Prot:O07906" /translation="MDEKDWILLKILHEEQSVTKTAERLFTSQPSITYRLKKIEEIFG IELFTKRHKGITFTAEGEHLVAYARRMLQELQDTKDHISNLSKEVQGHLRLGVSSNFA QYKLPKLLREFSTMYPNVQYSVQTGWSTDVMKLLDAGIVQVGILRGSHRWKGVEERLT REKLHIISKKPITIEQLPFLPFIKYKTDASLKTIIEDWMHTNLKQAPIIAMEVDRQET CKEMVKHGLGYSIAPEICLQESDHLYTMELYNAKGKPLMRDTWLMYDQKSLGIKLVKA FIDFLKGEQMVTI*" /label="yraN CDS" gene complement(2242366..2243235) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /label="yraN gene" promotor_-10 complement(2243258..2243277) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2243275) /Source="Nicolas_upshifts" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2243292..2243297) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2243342..2243343) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2243350) /Source="Nicolas_upshifts" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2243380..2243381) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2243380..2244483 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /EC_number="5.3.3.7" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11294638, 12473114, 14702315, 17567742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate isomerase" /protein_id="NP_390565.2" /db_xref="EnsemblGenomes-Gn:BSU26880" /db_xref="EnsemblGenomes-Tr:CAB14629" /db_xref="GOA:O07931" /db_xref="InterPro:IPR007400" /db_xref="SubtiList:BG12277" /db_xref="UniProtKB/Swiss-Prot:O07931" /translation="MVKTNVTIMRGGTSKGVFFHESAMPNNKNEWEPFLLDVMGSPDK RQIDGLGGGNSLTSKVAIIKKAYTSDIDVHYTFGQVSISEEKVDFKGNCGNISAAVGP FAIEEGLVKAKEPMTAVRILNTNTNKMIIAEVEVEDGQVKYDGDVTISGVPGSGSPIY LNFHDAAGSVTGHLLPTGNSSEFLDTSQGQIEVSIIDYANPLVFVEASSIGLDGTELA EEFTDLQLAQFEELRSIAAEKCGFASRFSATKLSPAVPKLAIVAKPEKYKDSTGAWHS SVEMDLHIRMMSMQKPHQALAVTGAICTTRALSVEGAIPARIAKNHSTKVRLAHSSGI IETMVEPTGIKIVRTARRIMDGTVYTHGDYQMM*" /label="prpF CDS" gene 2243380..2244483 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /label="prpF gene" misc_feature 2244373..2244392 /Source="Nicolas_upshift_promotors" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2244379 /Source="Nicolas_upshifts" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2244730) /Source="Nicolas_upshifts" /id="D1374" /incds=0 /nref=123 /ntot=254 /MaxReadThrough="2.33762" /MaxDrop="7.47213" /score="6.31571576" /energy="-8.7" /TU="U2071" /idTUdmin="U2071" /TUdmin="-33" /isTUend="FALSE" /label="downshifts" CDS complement(2244756..2245589) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /EC_number="3.2.1.132" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11065371, 11320136, 1664582, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11065371, 11320136, 1664582, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chitosanase" /protein_id="NP_390566.1" /db_xref="EnsemblGenomes-Gn:BSU26890" /db_xref="EnsemblGenomes-Tr:CAB14630" /db_xref="GOA:O07921" /db_xref="InterPro:IPR000400" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG11923" /db_xref="UniProtKB/Swiss-Prot:O07921" /translation="MKISMQKADFWKKAAISLLVFTMFFTLMMSETVFAAGLNKDQKR RAEQLTSIFENGTTEIQYGYVERLDDGRGYTCGRAGFTTATGDALEVVEVYTKAVPNN KLKKYLPELRRLAKEESDDTSNLKGFASAWKSLANDKEFRAAQDKVNDHLYYQPAMKR SDNAGLKTALARAVMYDTVIQHGDGDDPDSFYALIKRTNKKAGGSPKDGIDEKKWLNK FLDVRYDDLMNPANHDTRDEWRESVARVDVLRSIAKENNYNLNGPIHVRSNEYGNFVI K*" /label="csn CDS" gene complement(2244756..2245589) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /label="csn gene" misc_feature complement(2245619..2245638) /Source="Nicolas_upshift_promotors" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2245628) /Source="Nicolas_upshifts" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2245794..2245798 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2245809..2246031 /Source="Nicolas_S_feature" /locus_tag="new_2749037_2749259" /HighExp="Lbstat, M9-stat, B60, M0t90, M40t90, T1.30H, T2.0H, T3.0H, T2.30H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97565800000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1013" upshifts 2245809 /Source="Nicolas_upshifts" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2245813..2245832 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2246032..2246295 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390567.1" /db_xref="EnsemblGenomes-Gn:BSU26900" /db_xref="EnsemblGenomes-Tr:CAB14631" /db_xref="GOA:O07917" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12276" /db_xref="UniProtKB/Swiss-Prot:O07917" /translation="MAYVKATAILPEKLISEIQKYVQGKTIYIPKPESSHQKWGACSG TRKLIDDRNASIKKAFKNGKTIHQLSDEYHLSIETIKKIVYSK*" /label="yraL CDS" gene 2246032..2246295 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /label="yraL gene" downshifts 2246283 /Source="Nicolas_upshifts" /id="D1375" /incds=0 /nref=71 /ntot=223 /MaxReadThrough="1.7419" /MaxDrop="4.94534" /score="-1.04752822" /energy="-9.9" /TU="NA" /idTUdmin="U2072" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS 2246432..2247247 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390568.2" /db_xref="EnsemblGenomes-Gn:BSU26910" /db_xref="EnsemblGenomes-Tr:CAB14632" /db_xref="GOA:O07937" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12275" /db_xref="UniProtKB/Swiss-Prot:O07937" /translation="MTINNGTLQVPGANIHYQVRGSGPIILLVHGGGGDADKFHHVAN HLANWYTVVTYDRRGHSRSNLANQIEGYRVETHSDDAHRLLAKITNKPAYVFGSSSGA VIGLDLCIRHPEQVHVMIPHEPILLQLLHGNELKQAEQFMEDLKKNHRSEVIKLMSRL ETDEQSKAVLTKRLLGNSTYFTEYEIQGILSYTLDFEALKTVFTSSPMKILPAGGSAS RELFPYRCANALAEQLETEWVEFPGNHTGYTMYHKEFSERLHDMLEKEKKHTC*" /label="yraK CDS" gene 2246432..2247247 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /label="yraK gene" S_feature complement(2247582..2247654) /Source="Nicolas_S_feature" /locus_tag="new_2750810_2750882_c" /HighExp="BC, Lbstat, Sw, M40t90, M0t90, S2, BI, BT, S3, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1014" downshifts complement(2247625) /Source="Nicolas_upshifts" /id="D1376" /incds=0 /nref=44 /ntot=205 /MaxReadThrough="1.43644" /MaxDrop="4.78753" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2073" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2247655..2248011) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390569.2" /db_xref="EnsemblGenomes-Gn:BSU26920" /db_xref="EnsemblGenomes-Tr:CAB14633" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12274" /db_xref="UniProtKB/Swiss-Prot:O07934" /translation="MTKLKMLSMLTVMIASLFIFSSQALAVQYFTVSTSSGAPVNMRS GPGTNYPIMLSIPSGSRVPYYCYAYGTTVTGKYGTSNIWDQIQWKDSRGVVNIGYVSD TYVYTGSDGPVGYKCN*" /label="yraJ CDS" gene complement(2247655..2248011) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /label="yraJ gene" CDS complement(2248064..2248423) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390570.2" /db_xref="EnsemblGenomes-Gn:BSU26930" /db_xref="EnsemblGenomes-Tr:CAB14634" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12273" /db_xref="UniProtKB/Swiss-Prot:O07909" /translation="MNKLKRLSMLTVMIASVFIFSSHALAAQYYTVSTSSGAPVNMRS GPGTSWGIVTTIPSGTRIPIYCYKTGTTVTGKYGTSNIWNYTERTLASGEIVPGFVSD TYMYTGSDGPVVPKCSW*" /label="yraI CDS" gene complement(2248064..2248423) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /label="yraI gene" misc_feature complement(2248516..2248535) /Source="Nicolas_upshift_promotors" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2248526) /Source="Nicolas_upshifts" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2248695..2248796) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513987.1" /translation="MIGEKGGVSMNREEAWIQGSSTLIELIGGNEAA*" /label="hypothetical protein CDS" gene complement(2248695..2248796) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /label="gene" S_feature complement(2248836..2248938) /Source="Nicolas_S_feature" /locus_tag="new_2752064_2752166_c" /HighExp="M40t90, LBGstat, M40t45, M0t90, Lbstat, Lbtran, LBGtran, LPhT, ferm, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.575" /TUlongSig="NA" /TUlongPSig="NA" /label="S1015" downshifts complement(2248878) /Source="Nicolas_upshifts" /id="D1377" /incds=0 /nref=19 /ntot=188 /MaxReadThrough="2.12056" /MaxDrop="4.09264" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2074" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2248939..2249325) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390571.1" /db_xref="EnsemblGenomes-Gn:BSU26940" /db_xref="EnsemblGenomes-Tr:CAB14635" /db_xref="GOA:O07918" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12272" /db_xref="UniProtKB/Swiss-Prot:O07918" /translation="MKLLQIRLLVNDFKKSVEFYKDSLGLPISWLENEMEYALFDNGE TKIELLSRETMAEIVGEEKKSLEGEAQSKFLLQFKVEDVDKTYDDLHEKGVKCENKPH DRKEWSARVAHFRDPDHNLIEIYKML*" /label="yraH CDS" gene complement(2248939..2249325) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /label="yraH gene" misc_feature complement(2249367..2249383) /Source="Nicolas_upshift_promotors" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2249383) /Source="Nicolas_upshifts" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2249516..2249522 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2249537..2249548 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2249537 /Source="Nicolas_upshifts" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="upshifts" CDS 2249574..2249819 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390572.1" /db_xref="EnsemblGenomes-Gn:BSU26950" /db_xref="EnsemblGenomes-Tr:CAB14636" /db_xref="GOA:O07919" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG12271" /db_xref="UniProtKB/Swiss-Prot:O07919" /translation="MDHQTLAAHEAVDLHEIVNFKTLCIAKSKLMQGLVFDQELKDLM EKDVQQSIQDLTELQAVYERASFQAPVPQSRPTPIIN*" /label="yraG CDS" gene 2249574..2249819 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /label="yraG gene" CDS 2249837..2250205 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390573.1" /db_xref="EnsemblGenomes-Gn:BSU26960" /db_xref="EnsemblGenomes-Tr:CAB14637" /db_xref="GOA:O07949" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG12270" /db_xref="UniProtKB/Swiss-Prot:O07949" /translation="MNNDHLDPINSLNVPELADTTFAMDFLIRAKEGVRNTAVALTET ASPDVRALLRKQLMQGIAMHQEITELMISKKWFHPYELSEQYKLDQLSAKNTIMVGNM NLFPDETNRKGMFDRTPDEH*" /label="yraF CDS" gene 2249837..2250205 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /label="yraF gene" CDS 2250224..2251360 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7926692, 17586670; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (involving bacillithiol)" /protein_id="NP_390574.2" /db_xref="EnsemblGenomes-Gn:BSU26970" /db_xref="EnsemblGenomes-Tr:CAB14638" /db_xref="GOA:O06012" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR027399" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11902" /db_xref="UniProtKB/Swiss-Prot:O06012" /translation="MKAVTYQGIKNVVVKDVPDPKIEKSDDMIIKVTSTAICGSDLHL IHGFIPNMQEDYVIGHEPMGIVEEVGSGVTKLKKGDRVIIPFNIACGECFFCKNQLES QCDQSNDNGEMGAYFGYSGQTGGYPGGQAEYLRVPFANFTHFKIPESCEEPDEKLSVI ADAMTTGFWSVDNAGVKKGDTVIVLGCGPVGLFAQKFCWLKGAKRVIAVDYVNYRLQH AKRTNKVEIVNFEDHENTGNYLKEITKGGADVVIDAVGMDGKMSDLEFLASGLKLHGG TMSALVIASQAVRKGGTIQITGVYGGRYNGFPLGDIMQRNVNIRSGQAPVIHYMPYMF ELVSTGKIDPGDVVSHVLPLSEAKHGYDIFDSKMDDCIKVVLKP*" /label="adhB CDS" gene 2250224..2251360 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /label="adhB gene" CDS 2251379..2251576 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390575.1" /db_xref="EnsemblGenomes-Gn:BSU26980" /db_xref="EnsemblGenomes-Tr:CAB14639" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13780" /db_xref="UniProtKB/Swiss-Prot:O06011" /translation="MEYALHEVLEVQEMTAFKTLCLTKSKTMKALVSDPKLKEIMQQD VDITTRQLQEFASILSNAKQE*" /label="yraE CDS" gene 2251379..2251576 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /label="yraE gene" CDS 2251592..2251891 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390576.1" /db_xref="EnsemblGenomes-Gn:BSU26990" /db_xref="EnsemblGenomes-Tr:CAB14640" /db_xref="GOA:O06010" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG13779" /db_xref="UniProtKB/Swiss-Prot:O06010" /translation="MNPIIEYLTGMNVLTDQIIAMDLLISAKNGVRNYAMAATEAGTP EVKEVLIRHLEEALDMHEQLSSYMMEKGWYHPWNPDEQVKLNLKNIDTAIQLPTL*" /label="yraD CDS" gene 2251592..2251891 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /label="yraD gene" downshifts 2251882 /Source="Nicolas_upshifts" /id="D1378" /incds=0 /nref=11 /ntot=39 /MaxReadThrough="1.62449" /MaxDrop="3.8153" /score="-8.57687054" /energy="-10.7" /TU="NA" /idTUdmin="U2075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2252154..2252576) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 17962296, 19170879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 17962296, 19170879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulated by thiol-alkylation" /protein_id="NP_390578.2" /db_xref="EnsemblGenomes-Gn:BSU27000" /db_xref="EnsemblGenomes-Tr:CAB14642" /db_xref="GOA:O06008" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13777" /db_xref="UniProtKB/Swiss-Prot:O06008" /translation="MNIAQVAKQFGLTAATLRYYERVGLIPPVKRKDSGIRDYDEEDI KWIEFIKCMRNAGLSIEALIEYTTLFTEGDRTVEARKNILADERQRLIEKRKEIDETI KRLDTKIKDYDGKLRENEAKLKSRPKTESLHGSVEQRR*" /label="adhR CDS" gene complement(2252154..2252576) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /label="adhR gene" promotor_-35 2252574..2252577 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-35" promotor_-10 2252593..2252612 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-10" S_feature 2252608..2252758 /Source="Nicolas_S_feature" /locus_tag="new_2755836_2755986" /HighExp="Diami, dia15, dia5, H2O2, S8, Paraq, S5, G180, S6, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1016" upshifts 2252608 /Source="Nicolas_upshifts" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="upshifts" promotor_-10 complement(2252611..2252630) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2252618) /Source="Nicolas_upshifts" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2252644..2252651) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2252727..2252746) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-10" upshifts complement(2252735) /Source="Nicolas_upshifts" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="upshifts" CDS 2252759..2252953 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /EC_number="4.1.1.44" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17962296, 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxymuconolactone decarboxylase" /protein_id="YP_009513988.1" /db_xref="EnsemblGenomes-Gn:BSU27009" /db_xref="EnsemblGenomes-Tr:CAX52671" /db_xref="InterPro:IPR029032" /db_xref="UniProtKB/TrEMBL:C0H460" /translation="MANKHTAGREQLGEFAPKFAELHDDVLFGDIWAREEELSSRDRS MITVSALITDCFSAYKSGSF*" /label="yrzP CDS" gene 2252759..2252953 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /label="yrzP gene" promotor_-35 complement(2252761..2252768) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-35" promotor_-35 2252971..2252978 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-35" promotor_-10 2252994..2253013 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-10" upshifts 2252998 /Source="Nicolas_upshifts" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="upshifts" S_feature 2252999..2253083 /Source="Nicolas_S_feature" /locus_tag="new_2756227_2756311" /HighExp="LBGstat, dia15, Diami, LPhT, LBGtran, dia5, M40t90, Lbtran, H2O2, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.987, 0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1017" CDS 2253084..2254133 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase; carbonyl stressresponse" /protein_id="NP_390579.2" /db_xref="EnsemblGenomes-Gn:BSU27010" /db_xref="EnsemblGenomes-Tr:CAB14643" /db_xref="GOA:C0SPA5" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12562" /db_xref="UniProtKB/Swiss-Prot:C0SPA5" /translation="MCNQHQTRVLSVSHAKAKFEQTTIERRGLRPHDVLIDIKFSGIC HSDIHSAFDEWGGGIFPMVPGHEIAGVVTAVGTKVTKLAVGDRVGVGCFVDSCGECEY CLNAEEQFCTKGVVQTYNSVDYDGNPTYGGYSQKIVVTDRFVVRIPDRLEMDVASPLL CAGITTYSPLKHWNVGPGKKVAIVGVGGLGHLAIQFAHAMGAEVTVLSRSMNKKEEAL ELGANHYFATSDPATFTALAGRFDVILNTVSANLDVDAYLSMLRIDGTLVSVGAPAKP DTYSVFSLIMGRRSIAGSLVGGIQETQEMLDFAAEHGIEPKIEVIGADQVDEAYERIL RSDVRYRFVIDISTL*" /label="adhA CDS" gene 2253084..2254133 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /label="adhA gene" promotor_-35 2254201..2254208 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2254223..2254242 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2254236 /Source="Nicolas_upshifts" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="upshifts" CDS 2254264..2254773 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12775685, 17257049, 17933887, 24330391, 26774339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deglycase; general stress protecting enzyme; protects against methylglyoxal toxicity" /protein_id="NP_390580.2" /db_xref="EnsemblGenomes-Gn:BSU27020" /db_xref="EnsemblGenomes-Tr:CAB14644" /db_xref="GOA:O06006" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13776" /db_xref="UniProtKB/Swiss-Prot:O06006" /translation="MSKKIAVLVTDQFEDIEYTSPVKAYEEAGYSVVAIDLEAGKEVT GKHGEKVKIDKAISDVDASDFDALLIPGGFSPDLLRADDRPGEFAKAFVENKKPVFAI CHGPQVLIDTDLLKGKDITGYRSIRKDLINAGANYKDAEVVVSHNIVTSRTPDDLEAF NRESLNLLK*" /label="sufL CDS" gene 2254264..2254773 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /label="sufL gene" downshifts 2254742 /Source="Nicolas_upshifts" /id="D1379" /incds=0 /nref=178 /ntot=254 /MaxReadThrough="4.08169" /MaxDrop="5.1444" /score="24.8267602" /energy="-16.3" /TU="U2080" /idTUdmin="U2076" /TUdmin=528 /isTUend="FALSE" /label="downshifts" S_feature 2254787..2255892 /Source="Nicolas_S_feature" /locus_tag="new_2758015_2759120" /HighExp="Diami, dia5, Etha, dia15, LPhT, H2O2, Lbstat, Salt, Fru, Paraq" /AntisenseName="sacC" /AntisenseCor="0.18236909579254801" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.926" /label="S1018" CDS complement(2254815..2256848) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /EC_number="3.2.1.7" /EC_number="3.2.1.65" /EC_number="3.2.1.80" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7646030, 8057358, 10217495, 12224641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7646030, 8057358, 10217495, 12224641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levanase" /protein_id="NP_390581.1" /db_xref="EnsemblGenomes-Gn:BSU27030" /db_xref="EnsemblGenomes-Tr:CAB14645" /db_xref="GOA:P05656" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="PDB:4AZZ" /db_xref="PDB:4B1L" /db_xref="PDB:4B1M" /db_xref="SubtiList:BG10320" /db_xref="UniProtKB/Swiss-Prot:P05656" /translation="MKKRLIQVMIMFTLLLTMAFSADAADSSYYDEDYRPQYHFTPEA NWMNDPNGMVYYAGEYHLFYQYHPYGLQWGPMHWGHAVSKDLVTWEHLPVALYPDEKG TIFSGSAVVDKNNTSGFQTGKEKPLVAIYTQDREGHQVQSIAYSNDKGRTWTKYAGNP VIPNPGKKDFRDPKVFWYEKEKKWVMVLAAGDRILIYTSKNLKQWTYASEFGQDQGSH GGVWECPDLFELPVDGNPNQKKWVMQVSVGNGAVSGGSGMQYFVGDFDGTHFKNENPP NKVLWTDYGRDFYAAVSWSDIPSTDSRRLWLGWMSNWQYANDVPTSPWRSATSIPREL KLKAFTEGVRVVQTPVKELETIRGTSKKWKNLTISPASHNVLAGQSGDAYEINAEFKV SPGSAAEFGFKVRTGENQFTKVGYDRRNAKLFVDRSESGNDTFNPAFNTGKETAPLKP VNGKVKLRIFVDRSSVEVFGNDGKQVITDIILPDRSSKGLELYAANGGVKVKSLTIHP LKKVWGTTPFMSNMTGWTTVNGTWADTIEGKQGRSDGDSFILSSASGSDFTYESDITI KDGNGRGAGALMFRSDKDAKNGYLANVDAKHDLVKFFKFENGAASVIAEYKTPIDVNK KYHLKTEAEGDRFKIYLDDRLVIDAHDSVFSEGQFGLNVWDATAVFQNVTKES*" /label="sacC CDS" gene complement(2254815..2256848) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /label="sacC gene" downshifts complement(2254840) /Source="Nicolas_upshifts" /id="D1380" /incds=0 /nref=14 /ntot=60 /MaxReadThrough="0.56875" /MaxDrop="5.09923" /score="-2.07442916" /energy="-14.2" /TU="NA" /idTUdmin="U2081" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2256757..2256924) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513989.1" /translation="MPETDQLAQQSLLKVFKHEERSEGTNEKETDSSHDHVHPAVDYG IFGRCSRFKLL*" /label="hypothetical protein CDS" gene complement(2256757..2256924) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /label="gene" S_feature complement(2256849..2257004) /Source="Nicolas_S_feature" /locus_tag="new_2760077_2760232_c" /HighExp="UNK1, Fru, B60, T0.30H, M40t90, M0t90, ferm, LPh, GM-0.2, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.886" /TUlongSig="NA" /TUlongPSig="NA" /label="S1019" CDS complement(2257005..2257832) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IID component" /protein_id="NP_390582.1" /db_xref="EnsemblGenomes-Gn:BSU27040" /db_xref="EnsemblGenomes-Tr:CAB14646" /db_xref="GOA:P26382" /db_xref="InterPro:IPR004704" /db_xref="SubtiList:BG10319" /db_xref="UniProtKB/Swiss-Prot:P26382" /translation="MEKEKRLTKKEIFSMFIRSNFLLGSFNFERVQAMGYCYVMIPAI KKLYGPGAKRNEALQRHLEWFNTHPWLTAPIFGVTAAMEEEMANNKGIDGKAISGMKI GLMGPIAGVGDPIFWGTIRPVLAALGASLALGGNIAGPLLFFFLLNAIRLSTKYYGLK YGYVKGMEILQDLAGNRIQKLTEGASILGLFVMGALVSKWTTINIPIVVSRIKDESGK VDVQTVQNVLDSIMPGALPLGLTLLVAWMLRKGVNPLLIICGIFVIGILGYWAGFLA* " /label="levG CDS" gene complement(2257005..2257832) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /label="levG gene" CDS complement(2257853..2258662) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIC component" /protein_id="NP_390583.1" /db_xref="EnsemblGenomes-Gn:BSU27050" /db_xref="EnsemblGenomes-Tr:CAB14647" /db_xref="GOA:P26381" /db_xref="InterPro:IPR004700" /db_xref="SubtiList:BG10318" /db_xref="UniProtKB/Swiss-Prot:P26381" /translation="MSSLQIILLLIIAAITGIASVLDEGQTHRPLVACTLVGLVLGDL KTGIILGGTLELMALGWMNVGLAMAPDTAIASVISTILVITADQGIGEGIAVAVALAA AGQALTIFVRTITVFFIHRADQYAKAGNIKGIEIMHITAMVFQALRVMIPTLIVALIS VSAVQAFLGNIPDVITKGLQIGGGIIVVVGYAMVINMMNIPYLKPFFYIGFLLAAFTD FNLVGFGALGLCLALLYQQVMQKQSAHGAVAAASDSGSVAVYDDDDDDLDA*" /label="levF CDS" gene complement(2257853..2258662) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /label="levF gene" CDS complement(2258679..2259167) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /EC_number="2.7.1.202" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 9622354, 10589728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 9622354, 10589728; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIB component" /protein_id="NP_390584.1" /db_xref="EnsemblGenomes-Gn:BSU27060" /db_xref="EnsemblGenomes-Tr:CAB14648" /db_xref="GOA:P26380" /db_xref="InterPro:IPR004720" /db_xref="InterPro:IPR018455" /db_xref="InterPro:IPR036667" /db_xref="PDB:1BLE" /db_xref="SubtiList:BG10317" /db_xref="UniProtKB/Swiss-Prot:P26380" /translation="MNIVLARIDDRFIHGQILTRWIKVHAADRIIVVSDDIAQDEMRK TLILSVAPSNVKASAVSVSKMAKAFHSPRYEGVTAMLLFENPSDIVSLIEAGVPIKTV NVGGMRFENHRRQITKSVSVTEQDIKAFETLSDKGVKLELRQLPSDASEDFVQILRNV TK*" /label="levE CDS" gene complement(2258679..2259167) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /label="levE gene" CDS complement(2259167..2259607) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /EC_number="2.7.1.202" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIA component" /protein_id="NP_390585.1" /db_xref="EnsemblGenomes-Gn:BSU27070" /db_xref="EnsemblGenomes-Tr:CAB14649" /db_xref="GOA:P26379" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR013789" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10316" /db_xref="UniProtKB/Swiss-Prot:P26379" /translation="MISVIISGHGDFPIALKESSGMIFGEENNLIAVPFFKGEGIQTL QEKYHQALKDIPEEHEVLFLVDIFGGTPYNAAASFIAEDQRMDMAAGVNLPILLEVLS LREHLALKDLLNNLKAMSQQSFQVCSEHLEKVKTANQDTREDEL*" /label="levD CDS" gene complement(2259167..2259607) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /label="levD gene" downshifts 2259604 /Source="Nicolas_upshifts" /id="D1381" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="0.496260000000001" /MaxDrop="4.58461" /score="24.8267602" /energy="-16.3" /TU="NA" /idTUdmin="U2080" /TUdmin=3740 /isTUend="FALSE" /label="downshifts" misc_feature complement(2259644..2259662) /Source="Nicolas_upshift_promotors" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2259648) /Source="Nicolas_upshifts" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2259797..2262604) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NifA/NtrC family)" /protein_id="NP_390586.2" /db_xref="EnsemblGenomes-Gn:BSU27080" /db_xref="EnsemblGenomes-Tr:CAB14650" /db_xref="GOA:P23914" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10677" /db_xref="UniProtKB/Swiss-Prot:P23914" /translation="MRRIDKIYHQLKHNFHDSTLDHLLKIQGNSAKEIAEQLKMERSN VSFELNNLVRSKKVIKIKTFPVRYIPVEIAEKLFNKKWDTEMMEVKDLQAFSGNSKQN HQHISTNPLELMIGAKGSLKKAISQAKAAVFYPPNGLHMLLLGPTGSGKSLFANRIYQ FAIYSDILKAGAPFITFNCADYYNNPQLLLSQLFGHKKGSFTGAAEDKAGLVEQANGG ILFMDEIHRLPPEGQEMLFYFIDSGSYNRLGESEHKRTSNVLFICATTENPSSALLKT FLRRIPMTIHIPSLEERSLNERVDLTTFLLGKEAERIKKNLSVHIDVYNALIHSAKFG NVGQLKSNVQLVCAHGFLHNLDRNEVIELTVRDLPDEIKQEWMSSSKNMQRSKAISEY VNITTIISPIVEDETTKIDEDLSFNLYHLIEEKVKTLMKEGLSKKDINQYILTDVHLH VRSFFHHQAFQKDNLLTFVEDDVIQMTKQLKEIAEHELDCTFDRKFIYFLSMHIDAFL KRGKQIDVLNTQETDEIRDTHVKEYRVAMIFKDKIQEYFKVAIPEIEVIYLTMLIHSI KSLKENKRVGIIVAAHGNSTASSMVEVATELLGSTPIAAVDMPLTVSPSDILECVAEK MKQVDEGEGVLMLVDMGSLAMLESRLEEKTGISIKTISNVTTSMVLDAVRKVNYLNLN LHAIYQSVTKDFIELWERQPAASGKKKALVSICTTGSGTAKKLEDILTTIVNKASDTP IHILTVSSIKLANSIKEIEKEYEILATVGTKDPKINAPHVSLEVLIEGEGEKLIQQAI TKGSISLSNGLNEANIIVRELCEDSLKKYLVFLNPHHVIDMLLEWLQTVQDELGVIFN NAVLIKVIMHTAFAFERVIKQNPIAFSEEEEINDQLKEMVYVTERTLAPYEEKLGLRI SDDEKLFIAAIFAEEVHGQLF*" /label="levR CDS" gene complement(2259797..2262604) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /label="levR gene" misc_feature complement(2262820..2262839) /Source="Nicolas_upshift_promotors" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2262826) /Source="Nicolas_upshifts" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="upshifts" CDS 2263151..2263291 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513990.1" /translation="MTFLFYSAIQVESRVKNRATRHVTALKIVLKFKNKSIYSFKCYN IR*" /label="hypothetical protein CDS" gene 2263151..2263291 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /label="gene" misc_feature 2263272..2263291 /Source="Nicolas_upshift_promotors" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2263282 /Source="Nicolas_upshifts" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="upshifts" CDS 2263330..2264718 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17608695, 22084243; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small amino acid permease" /protein_id="NP_390587.2" /db_xref="EnsemblGenomes-Gn:BSU27090" /db_xref="EnsemblGenomes-Tr:CAB14651" /db_xref="GOA:O06005" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12556" /db_xref="UniProtKB/Swiss-Prot:O06005" /translation="MIGNSSKDNFGQQQKLSRGLKNRHIQLMAIGGAIGTGLFLGSGK SIHFAGPSILFAYLITGVFCFFIMRSLGELLLSNAGYHSFVDFVRDYLGNMAAFITGW TYWFCWISLAMADLTAVGIYTQYWLPDVPQWLPGLLALIILLIMNLATVKLFGELEFW FALIKVIAILALIVTGILLIAKGFSAASGPASLNNLWSHGGMFPNGWHGFILSFQMVV FAFVGIELVGLTAGETENPQKVIPKAINQIPVRILLFYVGALFVIMCIYPWNVLNPNE SPFVQVFSAVGIVVAASLINFVVLTSAASAANSALFSTSRMVYSLAKDHHAPGLLKKL TSSNVPSNALFFSSIAILIGVSLNYLMPEQVFTLITSVSTICFIFIWGITVICHLKYR KTRQHEAKANKFKMPFYPLSNYLTLAFLAFILVILALANDTRIALFVTPVWFVLLIIL YKVQTRRGHKVK*" /label="aapA CDS" gene 2263330..2264718 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /label="aapA gene" downshifts 2264707 /Source="Nicolas_upshifts" /id="D1382" /incds=0 /nref=7 /ntot=120 /MaxReadThrough="0.96985" /MaxDrop="3.54068" /score="11.8049306" /energy="-13" /TU="NA" /idTUdmin="U2083" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(2264740..2264813) /Source="Nicolas_S_feature" /locus_tag="new_2767968_2768041_c" /HighExp="MG 120, LBGstat, MG 150, MG 90, S0, HPh, HiOs, GM-0.1, aero, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1020" downshifts complement(2264782) /Source="Nicolas_upshifts" /id="D1383" /incds=0 /nref=11 /ntot=121 /MaxReadThrough="1.79954" /MaxDrop="4.59487" /score="37.881034" /energy="-13" /TU="NA" /idTUdmin="U2084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2264814..2265446) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16098526, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_390588.1" /db_xref="EnsemblGenomes-Gn:BSU27100" /db_xref="EnsemblGenomes-Tr:CAB14652" /db_xref="GOA:O05406" /db_xref="InterPro:IPR001123" /db_xref="InterPro:IPR004778" /db_xref="SubtiList:BG12304" /db_xref="UniProtKB/Swiss-Prot:O05406" /translation="MHSLLAYIPIAAMMVIIPGADTMLVMKNTLRYGPKAGRYNILGL ATGLSFWTVIAILGLSVVIAKSVILFTTIKYLGAAYLIYLGVKSFFAKSMFSLDDMQS QAKNMASSPKRYYKTSFMQGSLSNILNPKTVLVYVTIMPQFINLNGNINQQLIILASI LTLLAVLWFLFLVYIIDYAKKWMKNSKFQKVFQKITGIILVGFGIKTGLS*" /label="yrhP CDS" gene complement(2264814..2265446) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /label="yrhP gene" downshifts complement(2264870) /Source="Nicolas_upshifts" /id="D1384" /incds=0 /nref=4 /ntot=132 /MaxReadThrough="4.46187" /MaxDrop="3.11632" /score="37.881034" /energy="-13" /TU="U2084" /idTUdmin="U2084" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2265500..2265519) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2265511) /Source="Nicolas_upshifts" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2265525..2265531 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2265534..2265541) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2265545..2265564 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2265550 /Source="Nicolas_upshifts" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="upshifts" CDS 2265599..2266426 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator controlling amino acid export" /protein_id="NP_390589.1" /db_xref="EnsemblGenomes-Gn:BSU27110" /db_xref="EnsemblGenomes-Tr:CAB14653" /db_xref="InterPro:IPR002831" /db_xref="InterPro:IPR021586" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12303" /db_xref="UniProtKB/Swiss-Prot:O05405" /translation="MKENMLDILKNLNFTEYESKAYLALLQESPLTGYAVAKKSGVPR SKIYEVLESLVIRGDVFVSHGNTPQYVPVPAKELIKNRRLKAEEHFDQAEKYFEKFEQ TANDRENIWNITGRSEILEKVKACILSAKKRILLEIWKEDFKEIEAELKQAAEQGVIV TIIAYGDIVSDFANVYLHDMSSEITEEYDGRWLVYSGDDSEVVAGIVSLGNDSRAAWT MHVGLVMPITEVIIHDLYLMEILKKHRELLEESFGKNLIQLRRKFSIHSDFKKHYLE* " /label="yrhO CDS" gene 2265599..2266426 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /label="yrhO gene" downshifts 2266422 /Source="Nicolas_upshifts" /id="D1385" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="0.74814" /MaxDrop="5.12635" /score="6.64108595" /energy="-9.5" /TU="NA" /idTUdmin="U2085" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2266539..2266548 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2266561..2266576 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2266566 /Source="Nicolas_upshifts" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="upshifts" CDS 2266622..2267122 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 21926231, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 21926231, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma(V))" /protein_id="NP_390590.1" /db_xref="EnsemblGenomes-Gn:BSU27120" /db_xref="EnsemblGenomes-Tr:CAB14654" /db_xref="GOA:O05404" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11974" /db_xref="UniProtKB/Swiss-Prot:O05404" /translation="MKKKQTTKALLVTCITDHKQDFYRLAFSYVKNQDDALDIVQESI KKALSSVETVRNPETIKSWFYKILVRTAIDFLRKQKKIRVMDDETIEFLSKGKEDHYK DTDLHEALDELPYRYKTIIILRFFEDLKLEEIAEITGENTNTVKTRLYRALKLMRIQL TKEDLS*" /label="sigV CDS" gene 2266622..2267122 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /label="sigV gene" CDS 2267122..2267979 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(V) factor" /protein_id="NP_390591.1" /db_xref="EnsemblGenomes-Gn:BSU27130" /db_xref="EnsemblGenomes-Tr:CAB14655" /db_xref="GOA:O05403" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="PDB:5JEN" /db_xref="SubtiList:BG12302" /db_xref="UniProtKB/Swiss-Prot:O05403" /translation="MDKRLQQLREEYKNVQIPKELDIIVEKALQQEPKKKRIVMWPTS AAIAAAILFTALVNINPDAAQAMSKIPVIGKIVKAITFIEIKEEKDQSSIDVKTPALS GLSNKELENSINEKYLKESQQLYKEFIQSTSKNKKGHLSIYSDYETVTDTPDLLSIRR NIETTQASSYTQSRYITIDKKNDILLTLKSLFKDERYIKVISQNIKEQMKQQMKEDPN KIYWLTDEDAEPFKTILPDQTFYITEDHKLVISFDEYEVAPGYMGVTEFTIPTGVISN LLVGERYIR*" /label="rsiV CDS" gene 2267122..2267979 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /label="rsiV gene" promotor_-10 complement(2267997..2268008) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2268016) /Source="Nicolas_upshifts" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2268023..2268029) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2268090..2269994 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1521192, 15661003, 21135105, 21586574, 21856855, 21926231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1521192, 15661003, 21135105, 21586574, 21856855, 21926231; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan O-acetyltransferase" /protein_id="NP_390592.1" /db_xref="EnsemblGenomes-Gn:BSU27140" /db_xref="EnsemblGenomes-Tr:CAB14656" /db_xref="GOA:O05402" /db_xref="InterPro:IPR002656" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12301" /db_xref="UniProtKB/Swiss-Prot:O05402" /translation="MYHKTQHHRYIPGLDGLRAFAVLSVITYHLNFNWANGGFIGVDI FFVLSGYLITSILLPAYGNDINLDFRDFWVRRIRRLLPAAYLMIFSTVVWVVLFDREL LHTVRGDAISSLFYMSNWWFIFHKLSYFDSFGSPSPLKNLWSLAIEEQFYIIWPMFLV VGMYIMKSRARLAAVISLLVLCSAVMMSVLYEPGGDPSRVYYGTDTRSFELLIGCALA LVWPMKRLSSNRLPSKLKHTLHATEFLAFCILVLCVYFTDEYEPFLYRGGMLFISVTA AILIACVCHPSSFLGNLLSWRPLRWLGTRSYGIYLWHYPVIVLSTPVQEIGNPVFWHI VLKVIVTCILAELSYHFIEKPIRTQGFRSFSRRVFIHRIKEWKTTSVISKMSIGFIIF AILIFAGGLSGLAGEQKHPTKWTYSSQETNADTSQASGDKKNAAADKKHNPEQKTTDS NQGQKENKDSGQETHKKKDTQSQQLKKPADTAKEVLAIGDSVMLDISSHLRQSFSNVT IDGKVGRQMSQALELAREYKSFNQPNKAVIIELGTNGYFTNSQIEQLLQSFSKAHIYL VNTRVPRQWESKVNESLQQQAHAHQNVTLVDWHTEALQHPEYFTPDGVHLVPKGAKTL TALIVQAMKS*" /label="oatA CDS" gene 2268090..2269994 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /label="oatA gene" promotor_-35 2270075..2270081 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2270097..2270115 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2270103 /Source="Nicolas_upshifts" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="upshifts" CDS 2270128..2270418 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390593.1" /db_xref="EnsemblGenomes-Gn:BSU27150" /db_xref="EnsemblGenomes-Tr:CAB14657" /db_xref="GOA:O05401" /db_xref="InterPro:IPR025424" /db_xref="SubtiList:BG12300" /db_xref="UniProtKB/Swiss-Prot:O05401" /translation="MKGNEEHDIQKELKRYELFFKKRYKVLYTVNDFIIGAMFLVGSF FFFYDRLMSAGIWLFAIGSLLLLIRPTIRLIHDFHYRKHVEQQFKHQSSTDD*" /label="yrhK CDS" gene 2270128..2270418 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /label="yrhK gene" S_feature 2270419..2270534 /Source="Nicolas_S_feature" /locus_tag="new_2773647_2773762" /HighExp="Etha, Salt, LPhT, HiTm, G135, LBGstat, G180, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1021" promotor_-35 2270516..2270523 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2270536..2270661 /Source="Nicolas_S_feature" /locus_tag="new_2773764_2773889" /HighExp="Gly, G/S, Lbstat, C90, Pyr, LPhT, LoTm, Etha, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1022" upshifts 2270536 /Source="Nicolas_upshifts" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2270537..2270555 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2270555..2270655 /gene="surF" /locus_tag="BSU_misc_RNA_82" /product="small untranslated RNA expressed under sporulation conditions (SurF-AbrB)" /experiment="publication(s) with functional evidences, PMID:20709900, 25790031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 25790031; Product type n: RNA" /label="surF RNA" gene 2270555..2270655 /gene="surF" /locus_tag="BSU_misc_RNA_82" /label="surF gene" downshifts 2270618 /Source="Nicolas_upshifts" /id="D1386" /incds=0 /nref=7 /ntot=129 /MaxReadThrough="3.60641" /MaxDrop="5.24336" /score="25.0079309" /energy="-15.8" /TU="U2089" /idTUdmin="U2088" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(2270662..2273826) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /EC_number="1.14.14.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11574077, 12775685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077, 12775685; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP102A3" /protein_id="NP_390594.1" /db_xref="EnsemblGenomes-Gn:BSU27160" /db_xref="EnsemblGenomes-Tr:CAB14658" /db_xref="GOA:O08336" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12299" /db_xref="UniProtKB/Swiss-Prot:O08336" /translation="MKQASAIPQPKTYGPLKNLPHLEKEQLSQSLWRIADELGPIFRF DFPGVSSVFVSGHNLVAEVCDEKRFDKNLGKGLQKVREFGGDGLFTSWTHEPNWQKAH RILLPSFSQKAMKGYHSMMLDIATQLIQKWSRLNPNEEIDVADDMTRLTLDTIGLCGF NYRFNSFYRDSQHPFITSMLRALKEAMNQSKRLGLQDKMMVKTKLQFQKDIEVMNSLV DRMIAERKANPDENIKDLLSLMLYAKDPVTGETLDDENIRYQIITFLIAGHETTSGLL SFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIRMVLNETLRLYPTAPAF SLYAKEDTVLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDFRPERFEDPSSIPHHA YKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYELKIKEALTIKPDDFKIT VKPRKTAAINVQRKEQADIKAETKPKETKPKHGTPLLVLFGSNLGTAEGIAGELAAQG RQMGFTAETAPLDDYIGKLPEEGAVVIVTASYNGAPPDNAAGFVEWLKELEEGQLKGV SYAVFGCGNRSWASTYQRIPRLIDDMMKAKGASRLTAIGEGDAADDFESHRESWENRF WKETMDAFDINEIAQKEDRPSLSITFLSEATETPVAKAYGAFEGIVLENRELQTAAST RSTRHIELEIPAGKTYKEGDHIGILPKNSRELVQRVLSRFGLQSNHVIKVSGSAHMAH LPMDRPIKVVDLLSSYVELQEPASRLQLRELASYTVCPPHQKELEQLVSDDGIYKEQV LAKRLTMLDFLEDYPACEMPFERFLALLPSLKPRYYSISSSPKVHANIVSMTVGVVKA SAWSGRGEYRGVASNYLAELNTGDAAACFIRTPQSGFQMPNDPETPMIMVGPGTGIAP FRGFIQARSVLKKEGSTLGEALLYFGCRRPDHDDLYREELDQAEQDGLVTIRRCYSRV ENEPKGYVQHLLKQDTQKLMTLIEKGAHIYVCGDGSQMAPDVERTLRLAYEAEKAASQ EESAVWLQKLQDQRRYVKDVWTGM*" /label="cypB CDS" gene complement(2270662..2273826) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /label="cypB gene" downshifts complement(2270678) /Source="Nicolas_upshifts" /id="D1387" /incds=0 /nref=25 /ntot=213 /MaxReadThrough="2.3596" /MaxDrop="4.0425" /score="-9.99429269" /energy="-17.6" /TU="NA" /idTUdmin="U2091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2271812..2271821 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2271835..2271854 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2271856 /Source="Nicolas_upshifts" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2273842..2274426) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11574077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for cypB" /protein_id="NP_390595.1" /db_xref="EnsemblGenomes-Gn:BSU27170" /db_xref="EnsemblGenomes-Tr:CAB14659" /db_xref="GOA:O08335" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR032551" /db_xref="SubtiList:BG12298" /db_xref="UniProtKB/Swiss-Prot:O08335" /translation="MISASSSKYDMIMKASVSLFTERGFDATTIPMIAERAHVGTGTI YRYFDSKETLVNVLFQESIQRFTEKLKQDVSELPVREGFHHVFCCLVQFTKESDYALF FLETKKDAHYLNHTSKKMIENLTQMLDDYFNKGKAEGVIRSLPSNVLIAIVLGAFLKI YQLVQTGDIEMDTDLITELEQCCWDAIKLHSSQK*" /label="bscR CDS" gene complement(2273842..2274426) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /label="bscR gene" CDS complement(2274649..2275191) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390596.1" /db_xref="EnsemblGenomes-Gn:BSU27180" /db_xref="EnsemblGenomes-Tr:CAB14660" /db_xref="GOA:O05400" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12297" /db_xref="UniProtKB/Swiss-Prot:O05400" /translation="MLENRLYKRSDFWKLFSRKYKLTKTIEHMMIDSIDIQENDRILE IGIGNGTVFKSITKKLKKGSLKSIDPSKRKVRQISRANRKNMGNGEVFHGYPEDIPFD DRTFNKVFSLHTVQSCTDIRLALREIYRVLQIDGRFYISIDTNTGEKEKTYIQLLKDQ HFRDLSVIRRASCLCIVAVK*" /label="yrhH CDS" gene complement(2274649..2275191) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /label="yrhH gene" S_feature complement(2275192..2275277) /Source="Nicolas_S_feature" /locus_tag="new_2778420_2778505_c" /HighExp="T-0.40H, Salt, T0.30H, Heat, T0.0H, Etha, T-1.10H, T-1.40H, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1023" promotor_-10 complement(2275275..2275290) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2275277) /Source="Nicolas_upshifts" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2275303..2275312) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2275346..2275562) /Source="Nicolas_S_feature" /locus_tag="new_2778574_2778790_c" /HighExp="S7, S8, S6, LPhT, BT, LBGstat, S5, B36, G/S, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99909999999999999" /TUshortSig="SigK, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1024" CDS complement(2275380..2275538) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513991.1" /translation="MMNDYQKRLPSIGHGYASMPHSFKHGYGNPFRQQRLMAMQQQRL YVFPYHWH*" /label="hypothetical protein CDS" gene complement(2275380..2275538) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /label="gene" downshifts complement(2275389) /Source="Nicolas_upshifts" /id="D1388" /incds=0 /nref=34 /ntot=184 /MaxReadThrough="3.04168" /MaxDrop="7.65849" /score="23.6695072" /energy="-11.3" /TU="U2093" /idTUdmin="U2092" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2275560..2275579) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2275562) /Source="Nicolas_upshifts" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2275564..2275694) /Source="Nicolas_S_feature" /locus_tag="new_2778792_2778922_c" /HighExp="S7, S8, LPhT, S6, LBGstat, B36, BT, S5, Cold, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.893648" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1025" promotor_-35 complement(2275593..2275602) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2275695..2275844) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390597.1" /db_xref="EnsemblGenomes-Gn:BSU27190" /db_xref="EnsemblGenomes-Tr:CAB14661" /db_xref="InterPro:IPR012655" /db_xref="SubtiList:BG13819" /db_xref="UniProtKB/Swiss-Prot:O32027" /translation="MTINLFFLTLTIKKRFKSLEEFEREQQIEQIYDEMKESQLKHLY LTNWR*" /label="yrzI CDS" gene complement(2275695..2275844) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /label="yrzI gene" downshifts 2275838 /Source="Nicolas_upshifts" /id="D1389" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="1.96539" /MaxDrop="3.70444" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=4972 /isTUend="FALSE" /label="downshifts" S_feature complement(2275845..2275935) /Source="Nicolas_S_feature" /locus_tag="new_2779073_2779163_c" /HighExp="S7, LBGstat, Cold, S6, B36, LPhT, T-0.40H, LoTm, S8, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1026" S_feature complement(2275937..2276156) /Source="Nicolas_S_feature" /locus_tag="new_2779165_2779384_c" /HighExp="B60, B36, S7, BT, LBGstat, Cold, LoTm, LPhT, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52109300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1027" downshifts complement(2275980) /Source="Nicolas_upshifts" /id="D1390" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="7.23426" /MaxDrop="3.6023" /score="11.9275075" /energy="-19.6" /TU="U2093,U2094" /idTUdmin="U2094" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" downshifts 2276102 /Source="Nicolas_upshifts" /id="D1391" /incds=0 /nref=16 /ntot=94 /MaxReadThrough="0.94778" /MaxDrop="4.28987" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=5236 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2276135..2276154) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2276156) /Source="Nicolas_upshifts" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2276158..2276233) /Source="Nicolas_S_feature" /locus_tag="new_2779386_2779461_c" /HighExp="Lbexp, dia0, dia5, G150, Cold, C30, Mt0, LBGexp, dia15, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115567" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1028" promotor_-35 complement(2276169..2276176) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2276234..2277034) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 24887098; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative formate/nitrite transporter" /protein_id="NP_390598.1" /db_xref="EnsemblGenomes-Gn:BSU27200" /db_xref="EnsemblGenomes-Tr:CAB14662" /db_xref="GOA:O05399" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG12296" /db_xref="UniProtKB/Swiss-Prot:O05399" /translation="MAFRKPDEIAEAAIEAGMKKIKLPLPSLLVLGFLGGAFIALGYL LDIRVIGDLPKEWGSLSSLIGAAVFPVGLILVVLAGAELITGNMMSVAMALFSRKISV KELAINWGIVTIMNLIGALFVAYFFGHLVGLTETGPYLEKTIAVAQGKLDMSFGKVLI SAIGCNWLVCLAVWLSFGAQDAAGKILGIWFPIMAFVAIGFQHVVANMFVIPAAIFAG SFTWGQFIGNIIPAFIGNVIGGAVFVGLIYFIAYHKKDRSRKEMKQVS*" /label="yrhG CDS" gene complement(2276234..2277034) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /label="yrhG gene" S_feature complement(2277103..2277256) /Source="Nicolas_S_feature" /locus_tag="new_2780331_2780484_c" /HighExp="Lbexp, dia0, dia5, Cold, G150, Etha, HiOs, Salt, C90, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1029" downshifts complement(2277146) /Source="Nicolas_upshifts" /id="D1392" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="6.01922" /MaxDrop="3.7673" /score="23.461824" /energy="-25" /TU="U2094,U2095" /idTUdmin="U2095" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2277247..2277266) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-10" upshifts complement(2277256) /Source="Nicolas_upshifts" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="upshifts" promotor_-35 complement(2277281..2277287) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-35" CDS complement(2277297..2277665) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390599.1" /db_xref="EnsemblGenomes-Gn:BSU27210" /db_xref="EnsemblGenomes-Tr:CAB14663" /db_xref="InterPro:IPR018745" /db_xref="SubtiList:BG12295" /db_xref="UniProtKB/Swiss-Prot:O05398" /translation="MSKKIHEFNDIIRKLRKELFGKGPERIHTVFVENMAVSTLYGNL SASEQFIARTPEGREMVHAARTSLIQDLYSKQTPEGMEELMGAKLVHLFSDIKIEENI AVSVFVFDRKIDEQKEALQS*" /label="yrhF CDS" gene complement(2277297..2277665) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /label="yrhF gene" S_feature complement(2277666..2277762) /Source="Nicolas_S_feature" /locus_tag="new_2780894_2780990_c" /HighExp="T0.30H, LBGstat, T1.0H, T1.30H, G150, Lbexp, dia0, G180, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1030" promotor_-10 complement(2277748..2277767) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-10" promotor_-35 2277752..2277755 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2277768) /Source="Nicolas_upshifts" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="upshifts" promotor_-10 2277771..2277790 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2277773 /Source="Nicolas_upshifts" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="upshifts" S_feature 2277774..2277980 /Source="Nicolas_S_feature" /locus_tag="new_2781002_2781208" /HighExp="G150, Lbexp, dia0, Cold, dia5, G135, LBGstat, LBGexp, G180, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1031" promotor_-35 complement(2277783..2277787) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-35" CDS 2277981..2280923 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /EC_number="1.17.1.9" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913079, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative formate dehydrogenase" /protein_id="NP_390600.1" /db_xref="EnsemblGenomes-Gn:BSU27220" /db_xref="EnsemblGenomes-Tr:CAB14664" /db_xref="GOA:Q795Y4" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG12294" /db_xref="UniProtKB/Swiss-Prot:Q795Y4" /translation="MMDVKSISVRVDGTEIQARAGATILDILNENGIEYPQICHVPEV DPIQTCDTCIVEANGKLVRSCATVAENGMSIDLSGNRVKEAQTEAMDRLLENHLLYCT VCDNNNGNCTLHNTAEMMGIEHQKYPYTPKEDPSCAVDMSHPFYRYDPNQCIACGQCV EVCQNLQVNETLSIDWERERPRVIWDEGVPINESSCVSCGQCVTVCPCNALMEKSMLG QAGFMTGIKEDVMEPMIDLVKNVEPGYGSIFAISEVEAAMRETRTKKTKTVCTFCGVG CSFEVWTKGRDILKIQPVSDAPVNAISTCVKGKFGWDFVNSKERITKPLIRKNGAFVE SSWEEALDLVASRLGSIKEQYGKGSVGFISSSKITNEENYVIQKLARQVFETNNVDNC SRYCQSPATDGLFRTVGMGGDAGTIKDIAKAGLVIIVGANPAEGHPVLATRVKRAHKL HGQKLIVADLRKNEMAERSDLFISPKQGTDQVWLMAVTKYMIDQGWHDQAFIDENVNY FEDYKETLKTYTLDYAERITGLSKENIIQIAEMIRDADGTCVLWGMGVTQNTGGSDTS AAISNLLLATGNYRRPGAGAYPLRGHNNVQGACDMGTLPGWLPGYQHITDDKARAKFE EAYGVEIDGKPGLDNIQMLHAIEEGKMKAMYLVGEDMALVDSNANHVHDILSSLDFFV VQDIFLSRTAQYADVVLPATPSLEKDGTFTNTERRVQRLYQALPTLGDAKPDWWIIQE VANRLGANWNYSHPSDIFSEMASLSPLFAKASYEVLEGWNSFLWGSFTGESTPLLYED GFNFPDKKARFALSDWTEPAAFPEEYDLHINNGRMLEHFHEGNMTNKSKGIQAKVPNV FVEISPELAQERGVCDGSLVRLVSPFGAVKLNALITDRVRKNELYLPMNSTDKESAIN FLTGPAADKRTNTPAYKQTKVRMEVLGGCETAPLPKTNPRNKKRHPQNGVEAERKWNR PGYVHLTD*" /label="yrhE CDS" gene 2277981..2280923 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /label="yrhE gene" CDS 2280942..2281424 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10913079" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390601.1" /db_xref="EnsemblGenomes-Gn:BSU27230" /db_xref="EnsemblGenomes-Tr:CAB14665" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG12293" /db_xref="UniProtKB/Swiss-Prot:O05396" /translation="MATPITTIKKETKTAEQIKLEKIEELKELLAENEDAVSKTMTLM NELNDLGIFDAATSMLRAKEDIAKIALGQVSREPVTNLINTMMAAGGALTKADPEFTA KLLESVMAGTEQAQSFLKEDKKVGILDLLKAMNDPDINRAVGFGLQFLKGMGKELREQ *" /label="yrhD CDS" gene 2280942..2281424 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /label="yrhD gene" downshifts 2281404 /Source="Nicolas_upshifts" /id="D1393" /incds=0 /nref=65 /ntot=196 /MaxReadThrough="1.1227" /MaxDrop="6.19465" /score="27.8496451" /energy="-11.2" /TU="NA" /idTUdmin="U2096" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2281460..2281690) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17056751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390602.1" /db_xref="EnsemblGenomes-Gn:BSU27240" /db_xref="EnsemblGenomes-Tr:CAB14666" /db_xref="GOA:O05395" /db_xref="InterPro:IPR025418" /db_xref="SubtiList:BG12292" /db_xref="UniProtKB/Swiss-Prot:O05395" /translation="MNKNRMKSLKEDYKHFAFTLLAVSTFLYIGAVLPDQGLTLGQKS TMFLADCVFLAGAFFCADRSLIYKKRLEEADE*" /label="yrhC CDS" gene complement(2281460..2281690) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /label="yrhC gene" downshifts complement(2281480) /Source="Nicolas_upshifts" /id="D1394" /incds=0 /nref=60 /ntot=210 /MaxReadThrough="0.98344" /MaxDrop="5.84379" /score="15.2557797" /energy="-11.2" /TU="NA" /idTUdmin="U2097" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2281691..2281772) /Source="Nicolas_S_feature" /locus_tag="new_2784919_2785000_c" /HighExp="dia5, dia15, BT, Diami, B36, B60, nit, dia0, MG 10, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1032" CDS complement(2281773..2282912) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /EC_number="4.4.1.2" /EC_number="4.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-lyase and homocysteine gamma-lyase for reverse transsulfuration pathway" /protein_id="NP_390603.1" /db_xref="EnsemblGenomes-Gn:BSU27250" /db_xref="EnsemblGenomes-Tr:CAB14667" /db_xref="GOA:O05394" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12291" /db_xref="UniProtKB/Swiss-Prot:O05394" /translation="MKKKTLMIHGGITGDEKTGAVSVPIYQVSTYKQPKAGQHTGYEY SRTANPTRTALEALVTELESGEAGYAFSSGMAAITAVMMLFNSGDHVVLTDDVYGGTY RVMTKVLNRLGIESTFVDTSSREEVEKAIRPNTKAIYIETPTNPLLKITDLTLMADIA KKAGVLLIVDNTFNTPYFQQPLTLGADIVLHSATKYLGGHSDVVGGLVVTASKELGEE LHFVQNSTGGVLGPQDSWLLMRGIKTLGLRMEAIDQNARKIASFLENHPAVQTLYYPG SSNHPGHELAKTQGAGFGGMISFDIGSEERVDAFLGNLKLFTIAESLGAVESLISVPA RMTHASIPRERRLELGITDGLIRISVGIEDAEDLLEDIGQALENI*" /label="mccB CDS" gene complement(2281773..2282912) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /label="mccB gene" CDS complement(2282914..2283837) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /EC_number="2.5.1.47" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-synthase for the reverse transsulfuration pathway" /protein_id="NP_390604.1" /db_xref="EnsemblGenomes-Gn:BSU27260" /db_xref="EnsemblGenomes-Tr:CAB14668" /db_xref="GOA:O05393" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG12290" /db_xref="UniProtKB/Swiss-Prot:O05393" /translation="MTVITDITELIGNTPLLRLKNFDVPEGVAVYAKLEMMNPGGSIK DRLGDMLIRDALDSGKVKPGGVIIEATAGNTGIGLALSARKYGLKAIFCVPEHFSREK QQIMQALGASIIHTPRQDGMQGAIQKAIQLETEIENSYCVLQFKNRVNPSTYYKTLGP EMWEALDGNIHTFVAGAGSGGTFAGTASFLKEKNPAVKTVIVEPVGSILNGGEPHAHK TEGIGMEFIPDYMDKSHFDEIYTVTDENAFRLVKEAAEKEGLLIGSSSGAALYAALEE AKKASAGTNIVTVFPDSSDRYISKQIYEGGI*" /label="mccA CDS" gene complement(2282914..2283837) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /label="mccA gene" downshifts complement(2283830) /Source="Nicolas_upshifts" /id="D1395" /incds=0 /nref=16 /ntot=178 /MaxReadThrough="7.13056" /MaxDrop="3.40819" /score="0.994445584" /energy="-8.7" /TU="U2097,U2098,U2099" /idTUdmin="U2102" /TUdmin=1874 /isTUend="FALSE" /label="downshifts" S_feature complement(2283838..2283901) /Source="Nicolas_S_feature" /locus_tag="new_2787066_2787129_c" /HighExp="dia5, Diami, dia15, BT, B36, S6, LBGstat, S8, dia0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1033" CDS complement(2283902..2284597) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /EC_number="3.2.2.9" /EC_number="3.2.2.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioadenosine / S-adenosylhomocysteine nucleosidase" /protein_id="NP_390605.1" /db_xref="EnsemblGenomes-Gn:BSU27270" /db_xref="EnsemblGenomes-Tr:CAB14669" /db_xref="GOA:O32028" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR010049" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG13800" /db_xref="UniProtKB/Swiss-Prot:O32028" /translation="MRLAVIGAMEEEVTILRNKLENAKTETIAHCEFTTGEYEGTEVI LLKSGIGKVNAAISTTLLLDRYKPDYVINTGSAGGFHHTLNVGDVVISTDVRHHDVDV TAFDYEYGQVPGLPAAYAADEKLISITEEAVSELDGIQVAKGTIATGDSFMNDPKRVE EVRARFSDLYAVEMEAAAVAQVCHQFKTPFVVIRALSDIAGKESHVSFDQFLEQAAVH STELVLKVIKRIH*" /label="mtnN CDS" gene complement(2283902..2284597) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /label="mtnN gene" promotor_-10 complement(2284337..2284356) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2284355) /Source="Nicolas_upshifts" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2284369..2284378) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2284618..2285259) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 17056751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_390606.1" /db_xref="EnsemblGenomes-Gn:BSU27280" /db_xref="EnsemblGenomes-Tr:CAB14670" /db_xref="GOA:O32029" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023553" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13799" /db_xref="UniProtKB/Swiss-Prot:O32029" /translation="MGREFIPLFEDWAATYDQTVQGLDIQYKEAFRGYDHILDAIVRK SGTHVLEFGPGTGNLTAKLLDAGKTVFGIEPSPAMRKLASDKLSGRTEIVDGDFLTFP EPPFQADTIVSSYAFHHLTDEEKRAAIKQYGKYLHLHDKIVFADTVFENAQAYQQAID KARSQGFYQLANDLETEHYPTLDALKEMFTAEGFAVRFTQQNDFVWIMEAIKR*" /label="yrrT CDS" gene complement(2284618..2285259) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /label="yrrT gene" promotor_-10 complement(2284826..2284845) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2284845) /Source="Nicolas_upshifts" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2284862..2284865) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2285311..2285320 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2285317..2285336) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2285323) /Source="Nicolas_upshifts" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2285333..2285352 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2285342..2285406 /Source="Nicolas_S_feature" /locus_tag="new_2788570_2788634" /HighExp="BT, S6, S7, S8, S5, B36, G/S, Pyr, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1034" upshifts 2285342 /Source="Nicolas_upshifts" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2285352..2285355) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2285387..2285394 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2285408 /Source="Nicolas_upshifts" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2285410..2285427 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2285452..2285655 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390607.1" /db_xref="EnsemblGenomes-Gn:BSU27290" /db_xref="EnsemblGenomes-Tr:CAB14671" /db_xref="InterPro:IPR019686" /db_xref="SubtiList:BG13811" /db_xref="UniProtKB/Swiss-Prot:O32030" /translation="MNFQLDLIKDKVEFFEAASLQELEKKINTQIENNKAIMLRVKSV SHQTLVAEGRILYSAVVHFSAEA*" /label="yrzA CDS" gene 2285452..2285655 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /label="yrzA gene" downshifts 2285662 /Source="Nicolas_upshifts" /id="D1396" /incds=0 /nref=205 /ntot=257 /MaxReadThrough="1.11529" /MaxDrop="5.39095" /score="26.0850303" /energy="-14.2" /TU="NA" /idTUdmin="U2101" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2285692..2286393) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679248" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390608.1" /db_xref="EnsemblGenomes-Gn:BSU27300" /db_xref="EnsemblGenomes-Tr:CAB14672" /db_xref="GOA:O32031" /db_xref="InterPro:IPR009988" /db_xref="SubtiList:BG13798" /db_xref="UniProtKB/Swiss-Prot:O32031" /translation="MSNNQSRYENRDKRRKANLVLNILIAIVSILIVVVAANLFINSP SSKDVSKDSETAQKQESPASGKTEKKSDEDIKDSKKDTSDSEKDSEKSSDSDSKKDDS SSKKDDSDSDSSSDSAGDGLKDAKVTEGGSSSDVEKTYENPDWKAVGTEQTGEHAATY DSSSQDWAEMLKAISYATGVSTDNMTVLWLGNNGSPQDAKGKILDKATGNKYQVTITW VDEKGWKPTKVEKLK*" /label="yrrS CDS" gene complement(2285692..2286393) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /label="yrrS gene" downshifts complement(2285704) /Source="Nicolas_upshifts" /id="D1397" /incds=0 /nref=237 /ntot=265 /MaxReadThrough="1.64695" /MaxDrop="6.48551" /score="22.1367505" /energy="-14.2" /TU="NA" /idTUdmin="U2102" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2286458..2288212) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14679248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein PBP4B" /protein_id="NP_390609.1" /db_xref="EnsemblGenomes-Gn:BSU27310" /db_xref="EnsemblGenomes-Tr:CAB14673" /db_xref="GOA:O32032" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13797" /db_xref="UniProtKB/Swiss-Prot:O32032" /translation="MKISKRMKLAVIAFLIVFFLLLLRLAEIQLFFTESFSKKKINLI QESVKQRTEEVLISDGRGSFLDRNGRALTGQSEPAVVLFPFLLTQDWPIKKVADILGM SEDDLRQTLGQAKKPVILQQKKIKTLSKQSITKINSLKYPGIYGVYMENEDKPSLASH TIGSTNQDPALLRKKYPDKESLPITTEIGTTGLERTFDEFLLPEQDTKLLYHVDGKGN PLFGMDVKYTAEANTFYPLQIKTTIDQSIQKAMEEVLDEQGLKKGGAVLLDIENSSVL GIVSKPDADVSRQNTLQNYMLTPIYPGSVFKTVIAAAAIENNMVKPSQTFNCNLNLYG EPGDDKGTLSFDESFAQSCNYTFTSLAEQLMKKDSSVIEDMSEKLALTDRAGWEGKLY HETDFRQLYNEKSGVIWGDEKDKSVKKAIAQTAIGQKNVKVTPLEVANMMATIARGGE KRQVKIAEQIEYKNGTTLVTFKDQKLKGETIDKYTSQQLQKILRRVVESPSGTGRRFQ DLPYTVAGKSGTAQTGKLSKEKETLYEKWFAGYFPADKPKYALVVLHMDTPGDKALTN SVFYDIVKKVHEIEINQK*" /label="pbpI CDS" gene complement(2286458..2288212) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /label="pbpI gene" misc_feature complement(2286486..2286505) /Source="Nicolas_upshift_promotors" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2286496) /Source="Nicolas_upshifts" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2287527..2287542) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2287530) /Source="Nicolas_upshifts" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2287555..2287564) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2287758..2287776) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2287772) /Source="Nicolas_upshifts" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2287791..2287798 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2287791..2287796) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2287813..2287832 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2287818 /Source="Nicolas_upshifts" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2288266..2288739) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10910724, 16014871, 16707701, 21515770, 28976965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10910724, 16014871, 16707701, 21515770, 28976965; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription elongation factor resolving backtracking / stalling" /protein_id="NP_390610.1" /db_xref="EnsemblGenomes-Gn:BSU27320" /db_xref="EnsemblGenomes-Tr:CAB14674" /db_xref="GOA:P80240" /db_xref="InterPro:IPR001437" /db_xref="InterPro:IPR006359" /db_xref="InterPro:IPR018151" /db_xref="InterPro:IPR022691" /db_xref="InterPro:IPR023459" /db_xref="InterPro:IPR028624" /db_xref="InterPro:IPR036805" /db_xref="InterPro:IPR036953" /db_xref="SubtiList:BG19019" /db_xref="UniProtKB/Swiss-Prot:P80240" /translation="MAQEKVFPMTAEGKQKLEQELEYLKTVKRKEVVERIKIARSFGD LSENSEYDSAKEEQAFVEGRVTTLENMIRNAKIIEDDGGSNVVGLGKTVTFVELPDGD EESYTIVGSAEADPFEGKISNDSPIAKSLLGKKVDEEVTVQTPGGEMLVKIVKIS*" /label="greA CDS" gene complement(2288266..2288739) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /label="greA gene" downshifts complement(2288273) /Source="Nicolas_upshifts" /id="D1398" /incds=0 /nref=130 /ntot=229 /MaxReadThrough="5.30316" /MaxDrop="4.90519" /score="34.2316821" /energy="-17" /TU="U2107" /idTUdmin="U2106" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(2288740..2288872) /Source="Nicolas_S_feature" /locus_tag="new_2791968_2792100_c" /HighExp="HPh, C90, dia5, dia15, Diami, H2O2, dia0, Etha, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1035" promotor_-10 complement(2288854..2288873) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2288872) /Source="Nicolas_upshifts" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2288874..2288982) /Source="Nicolas_S_feature" /locus_tag="new_2792102_2792210_c" /HighExp="HPh, G180, G135, LBGexp, dia0, Paraq, Oxctl, G150, LPh, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1036" promotor_-35 complement(2288887..2288894) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2288975..2288994) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2288982) /Source="Nicolas_upshifts" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2288990..2289625) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /EC_number="2.7.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 6208029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridine kinase" /protein_id="NP_390611.1" /db_xref="EnsemblGenomes-Gn:BSU27330" /db_xref="EnsemblGenomes-Tr:CAB14675" /db_xref="GOA:O32033" /db_xref="InterPro:IPR000764" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR026008" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12696" /db_xref="UniProtKB/Swiss-Prot:O32033" /translation="MGKNPVVIGIAGGSGSGKTSVTRSIYEQFKGHSILMIQQDLYYK DQSHLPFEERLNTNYDHPLAFDNDYLIEHIQDLLNYRPIEKPIYDYKLHTRSEETVHV EPKDVIILEGILVLEDKRLRDLMDIKLYVDTDADLRIIRRIMRDINERGRSIDSVIEQ YVSVVRPMHNQFVEPTKRYADIIIPEGGQNHVAIDLMVTKIQTILEQNAIL*" /label="udk CDS" gene complement(2288990..2289625) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /label="udk gene" promotor_-35 complement(2289010..2289014) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2289120..2289125 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2289141..2289159 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2289148 /Source="Nicolas_upshifts" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2289632..2290900) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase large subunit" /protein_id="NP_390612.1" /db_xref="EnsemblGenomes-Gn:BSU27340" /db_xref="EnsemblGenomes-Tr:CAB14676" /db_xref="GOA:O32034" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032525" /db_xref="SubtiList:BG13796" /db_xref="UniProtKB/Swiss-Prot:O32034" /translation="MTAVNDKISTIVNGKRVITKKPELLAPAGNLEKLKIAVHYGADA VFIGGQEYGLRSNADNFTIEEIAEGVEFAKKYGAKIYVTTNIFAHNENMDGLEDYLKA LGDANVAGIIVADPLIIETCRRVAPNVEVHLSTQQSLSNWKAVQFWKEEGLDRVVLAR ETSALEIREMKEKVDIEIESFIHGAMCIAYSGRCVLSNHMTARDSNRGGCCQSCRWDY DLYQTDGANAVALYGEEDAPFAMSPKDLKLIESIPKMIEMGIDSLKIEGRMKSIHYVA TVVSVYRKVIDAYCADPENFVIQKEWLEELDKCANRDTATAFFEGTPGYEEQMFGEHA KKTTYDFVGLVLNYDEDTQMVTLQQRNFFKKGDEVEFFGPEIENFTHTIETIWDEDGN ELDAARHPLQIVKFKLDKKIYPSNMMRKGK*" /label="yrrO CDS" gene complement(2289632..2290900) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /label="yrrO gene" CDS complement(2290919..2291848) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase small subunit" /protein_id="NP_390613.1" /db_xref="EnsemblGenomes-Gn:BSU27350" /db_xref="EnsemblGenomes-Tr:CAB14677" /db_xref="GOA:O32035" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG13795" /db_xref="UniProtKB/Swiss-Prot:O32035" /translation="MKKPELLVTPTSTADILPLIQAGATAFLVGEQRYGLRLAGEFSR EDVTKAVEIAHKEGAKVYVAVNAIFHNDKVGELGEYLAFLAEAGVDAAVFGDPAVLMA ARESAPDLKLHWSTETTGTNYYTCNYWGRKGAARSVLARELNMDSIVEIKENAEVEIE IQVHGMTCMFQSKRSLIGNYFEYQGKVMDIERKKKESGMFLHDKERDNKYPIFEDENG THIMSPNDVCIIDELEELIDAGIDSFKIDGVLKMPEYLIEVTKMYREAIDLCVENRDE YEAKKEDWIERIESIQPVNRKIDTGFFFKETVY*" /label="yrrN CDS" gene complement(2290919..2291848) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /label="yrrN gene" CDS complement(2291854..2292507) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /EC_number="2.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA O-methyltransferase" /protein_id="NP_390614.1" /db_xref="EnsemblGenomes-Gn:BSU27360" /db_xref="EnsemblGenomes-Tr:CAB14678" /db_xref="GOA:O32036" /db_xref="InterPro:IPR002935" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13794" /db_xref="UniProtKB/Swiss-Prot:O32036" /translation="MTDRYEQINDYIEALLKPRPDNVKRLEAYAEEHHVPIMEKAGME VLLQILSVKQPKKILEIGTAIGYSAIRMALELPSAEIYTIERNEKRHEEAVNNIKEFQ LDDRIHVFYGDALELADAVHVTAPYDVIFIDAAKGQYQNFFHLYEPMLSPDGVIITDN VLFKGLVAEDYSKIEPKRRRRLVAKIDEYNHWLMNHPDYQTAIIPVGDGLAISKKKR* " /label="yrrM CDS" gene complement(2291854..2292507) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /label="yrrM gene" S_feature complement(2292508..2292612) /Source="Nicolas_S_feature" /locus_tag="new_2795736_2795840_c" /HighExp="LBGexp, G180, H2O2, G150, Paraq, Oxctl, G135, dia15, C30, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1037" promotor_-10 complement(2292594..2292613) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2292612) /Source="Nicolas_upshifts" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2292629..2292633) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2292659..2293741) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved membrane associated protein" /protein_id="NP_390615.1" /db_xref="EnsemblGenomes-Gn:BSU27370" /db_xref="EnsemblGenomes-Tr:CAB14679" /db_xref="GOA:O34758" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13793" /db_xref="UniProtKB/Swiss-Prot:O34758" /translation="MYINQQKKSFFNKKRIILSSIVVLFLIIGGAFLYGKSLLEPVEK DSKTTVNINIPSGSSVSAIASILKKNDVIKSEKAFQYYVKYKGASGFQAGFYHLNKGM DLDAIIQKLTSGATGYAFQITVTEGAQLTQIAAAIADETKYSKKQVIAKLDDETFINQ LKKEFPDTVTNDVFNKNIKHPLEGYLFPATYPFNDPDTSLEDIIKAMIKQTNSYVETY KSEMKKNKVSVHKLLTMASLIEEEATEKADRHKIASVFYNRLKKKMPLQTDPTVLYAA GKHKDRVLYKDLEIDSPYNTYKNTGLTPGPIANAGMSSWEAALHPDKTDYLYFLAKSN GEVVFTKTLKEHNKAKEKYISSKNEK*" /label="yrrL CDS" gene complement(2292659..2293741) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /label="yrrL gene" downshifts complement(2292693) /Source="Nicolas_upshifts" /id="D1399" /incds=0 /nref=21 /ntot=144 /MaxReadThrough="3.5258" /MaxDrop="3.97301" /score="10.5327118" /energy="-11" /TU="U2110" /idTUdmin="U2111" /TUdmin=1173 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2293757..2293776) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2293777) /Source="Nicolas_upshifts" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2293791..2293794) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2293867) /Source="Nicolas_upshifts" /id="D1400" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="2.55298" /MaxDrop="6.9121" /score="36.0941054" /energy="-15" /TU="NA" /idTUdmin="U2111" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2293872..2294153) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_390616.1" /db_xref="EnsemblGenomes-Gn:BSU27380" /db_xref="EnsemblGenomes-Tr:CAB14680" /db_xref="InterPro:IPR009711" /db_xref="SubtiList:BG13812" /db_xref="UniProtKB/Swiss-Prot:O34828" /translation="MEHGEKNITIVDDQGNEQLCEVLFTFENEEFGKSYVLYYPIESK DDEEVEILASSFTPNEDGENGELFPIETDEEWDMIEETLNTFLADEDEE*" /label="yrzB CDS" gene complement(2293872..2294153) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /label="yrzB gene" downshifts complement(2293932) /Source="Nicolas_upshifts" /id="D1401" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.68915" /MaxDrop="5.19246" /score="36.0941054" /energy="-15" /TU="U2111,U2113,U2114,U2115" /idTUdmin="U2111" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2294171..2294587) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 14512736, 16021622, 22720735, 23251031, 25545592; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pre-16S ribosomal RNA maturation enzyme" /protein_id="NP_390617.1" /db_xref="EnsemblGenomes-Gn:BSU27390" /db_xref="EnsemblGenomes-Tr:CAB14681" /db_xref="GOA:O34634" /db_xref="InterPro:IPR005227" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR037027" /db_xref="PDB:1VHX" /db_xref="SubtiList:BG13792" /db_xref="UniProtKB/Swiss-Prot:O34634" /translation="MRILGLDLGTKTLGVALSDEMGWTAQGIETIKINEAEGDYGLSR LSELIKDYTIDKIVLGFPKNMNGTVGPRGEASQTFAKVLETTYNVPVVLWDERLTTMA AEKMLIAADVSRQKRKKVIDKMAAVMILQGYLDSLN*" /label="rimF CDS" gene complement(2294171..2294587) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /label="rimF gene" promotor_-10 complement(2294419..2294437) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2294438) /Source="Nicolas_upshifts" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2294453..2294458) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2294595..2294861) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_054589.1" /db_xref="EnsemblGenomes-Gn:BSU27400" /db_xref="EnsemblGenomes-Tr:CAE01464" /db_xref="InterPro:IPR009309" /db_xref="SubtiList:BG14184" /db_xref="UniProtKB/Swiss-Prot:Q7WY61" /translation="MSSFDKTMKFNFSDDSAETNVNEVLITVYDALQEKGYNPINQIV GYLLSGDPAYIPRHRDARNLIRKLERDELIEELVKSYLEQHKEA*" /label="yrzL CDS" gene complement(2294595..2294861) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /label="yrzL gene" promotor_-35 2294749..2294757 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2294772..2294791 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2294780..2295969 /Source="Nicolas_S_feature" /locus_tag="new_2798008_2799197" /HighExp="S6, C30, C90, S8, S7, Gly, G135, Fru, G180, M/G" /AntisenseName="alaS" /AntisenseCor="-0.27843994691040502" /AntisenseRegPval="-5.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1038" upshifts 2294780 /Source="Nicolas_upshifts" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2294862..2294922) /Source="Nicolas_S_feature" /locus_tag="new_2798090_2798150_c" /HighExp="LBGtran, LBGexp, G135, C90, G150, G180, LBGstat, Oxctl, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.994, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1039" promotor_-10 complement(2294916..2294935) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2294922) /Source="Nicolas_upshifts" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2294946..2297582) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /EC_number="6.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12554667, 12682299, 17329819, 22720735, 25918376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanyl-tRNA synthetase" /protein_id="NP_390618.1" /db_xref="EnsemblGenomes-Gn:BSU27410" /db_xref="EnsemblGenomes-Tr:CAB14682" /db_xref="GOA:O34526" /db_xref="InterPro:IPR002318" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018162" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR018164" /db_xref="InterPro:IPR018165" /db_xref="InterPro:IPR023033" /db_xref="SubtiList:BG12563" /db_xref="UniProtKB/Swiss-Prot:O34526" /translation="MKHLTSAEVRQMFLDFFKEKGHAVEPSASLVPHEDPSLLWINSG VATLKKYFDGRVVPENPRIVNAQKAIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKE EAITWAWEFLTSDKWIGFDKELLSVTVHPEDEEAYEFWAKKIGIPEERIIRLEGNFWD IGEGPSGPNTEIFYDRGEAYGNDPEDPELYPGGENDRYLEVWNLVFSEFNHNPDGTYT PLPKKNIDTGMGLERMVSVIQNVPTNFDTDLFVPIIKATESISGETYGKDNVKDTAFK VIADHIRTVAFAVSDGALPSNEGRGYVLRRLLRRAVRYAKTINIHRPFMFDLVPVVAE IMADFYPEVKEKADFIAKVIKTEEERFHETLNEGLAILSEMIKKEKDKGSSVISGADV FKLYDTYGFPVELTEEYAEDENMTVDHEGFEEEMNQQRERARNARQDVGSMQVQGGAL RDVTVESTFVGYSQTKADANIIVLLQDGQLIEEAHEGESVQIILDETPFYAESGGQIG DKGYLRSEQAVVRIKDVQKAPNGQHVHEGVVESGTVQKGLHVTAEVEDHMRSGVIKNH TATHLLHQALKDVLGTHVNQAGSLVTENRLRFDFSHFGQVTKEELEQIERIVNEKIWA SIPVSIDLKPIAEAKEMGAMALFGEKYGDIVRVVQVGDYSLELCGGCHVRNTAEIGLF KIVSESGIGAGTRRIEAVTGQGAYVEMNSQISVLKQTADELKTNIKEVPKRVAALQAE LKDAQRENESLLAKLGNVEAGAILSKVKEVDGVNVLAAKVNAKDMNHLRTMVDELKAK LGSAVIVLGAVQNDKVNISAGVTKDLIEKGLHAGKLVKQAAEVCGGGGGGRPDMAQAG GKQPEKLEEALASVEDWVKSVL*" /label="alaS CDS" gene complement(2294946..2297582) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /label="alaS gene" promotor_-35 complement(2294949..2294956) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2297348..2297366) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2297364) /Source="Nicolas_upshifts" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2297380..2297387) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2297583..2297661) /Source="Nicolas_S_feature" /locus_tag="new_2800811_2800889_c" /HighExp="G150, LBGexp, G135, G180, Oxctl, LBGtran, Lbexp, Paraq, dia15, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1040" misc_RNA complement(2297662..2297869) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /product="T-box riboswitch specific of alanine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboA RNA" gene complement(2297662..2297869) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /label="tboA gene" promotor_-10 complement(2297877..2297896) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2297892) /Source="Nicolas_upshifts" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2297911..2297918) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2297913..2298974) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_390619.1" /db_xref="EnsemblGenomes-Gn:BSU27420" /db_xref="EnsemblGenomes-Tr:CAB14683" /db_xref="GOA:O34472" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13791" /db_xref="UniProtKB/Swiss-Prot:O34472" /translation="MLQKPVQLLLWVAICLLVLLTVYVFFMLDMLWSPFWLVIKTIFI PLIISIFISYLLLPVTEWLHGKGLPRTLSILVIYVLFFGGIGWALYKGVPVLIVQLTD LSENIPMFAETYNGLLLHVHNHTDDWPDGMHHRIDKMIRQTEAFFAGTIEGAISGIRN VLDYFLIAATIPFLVFYMVKDIELMKKTVWYLTPKSWRKRGSAFLRDVDDSLGDYIRG QLLVCLILGVIAGISFWVFGLPYPLILGLISGVTNVIPYFGPFIGAVPALLIAMTISV KAVLVVVITVFILQFMEGNILSPFIVGRSLKMHPVVIMLALLAGGELAGIVGMILAVP ATAVLKVMMIHFLRMRTEH*" /label="yrrI CDS" gene complement(2297913..2298974) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /label="yrrI gene" promotor_-35 2298883..2298888 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2298894..2299129 /Source="Nicolas_S_feature" /locus_tag="new_2802122_2802357" /HighExp="S5, S6, S4, S8, S3, S7, LoTm, BT, M9-stat, T5.0H" /AntisenseName="yrrI" /AntisenseCor="0.71790030040923003" /AntisenseRegPval="-43.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1041" upshifts 2298895 /Source="Nicolas_upshifts" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2298904..2298922 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2298991..2299002) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2298992) /Source="Nicolas_upshifts" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2299016..2299022) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2299130..2299858 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (ATP-binding protein)" /protein_id="NP_390620.1" /db_xref="EnsemblGenomes-Gn:BSU27430" /db_xref="EnsemblGenomes-Tr:CAB14684" /db_xref="GOA:O34677" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11485" /db_xref="UniProtKB/Swiss-Prot:O34677" /translation="MITFQNVNKHYGDFHVLKQINLQIEKGEVVVIIGPSGSGKSTLL RCINRLESINEGVLTVNGTAINDRKTDINQVRQNIGMVFQHFHLYPHKTVLQNIMLAP VKVLRQSPEQAKETARYYLEKVGIPDKADAYPSQLSGGQQQRVAIARGLAMKPEVMLF DEPTSALDPEMIGEVLDVMKTLAKEGMTMVVVTHEMGFAKEVADRIVFIDEGKILEEA VPAEFYANPKEERARLFLSRILNH*" /label="glnQ CDS" gene 2299130..2299858 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /label="glnQ gene" downshifts complement(2299586) /Source="Nicolas_upshifts" /id="D1402" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="1.29649" /MaxDrop="3.29152" /score="-3.35464926" /energy="-5.4" /TU="NA" /idTUdmin="U2117" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" CDS 2299880..2300701 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (glutamine-binding lipoprotein)" /protein_id="NP_390621.1" /db_xref="EnsemblGenomes-Gn:BSU27440" /db_xref="EnsemblGenomes-Tr:CAB14685" /db_xref="GOA:O34563" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11486" /db_xref="UniProtKB/Swiss-Prot:O34563" /translation="MKKIFSLALISLFAVILLAACGSKGSNGEASKESKKDTLAAIKD NDKIVFGVKTDTRLFGLKNPSSGEIEGFDIDIAKQIAKDILGDEKKAQFKEVTSKTRI PMLQNGDIDAIVATMTITEERKKEVDFSDVYFEAGQSLLVKKGSKIKSVENLGKGSKV LAVKGSTSSQNIREKAPEASVLEFENYAEAFTALKSGQGDALTTDNAILYGMADENKN YQLTGKPFTDEPYGIAVKKGQSALAKEINASLKKMKSDGRYDEIYKKWIKEDPAE*" /label="glnH CDS" gene 2299880..2300701 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /label="glnH gene" CDS 2300762..2301412 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390622.1" /db_xref="EnsemblGenomes-Gn:BSU27450" /db_xref="EnsemblGenomes-Tr:CAB14686" /db_xref="GOA:O34671" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11487" /db_xref="UniProtKB/Swiss-Prot:O34671" /translation="MNVSILFDNFSMYMDGFYHTLLASVIALAGSFVLGVAVAVMRIT VFKPLQWLGTAYVEFIRNIPLLLITFVFYFGLPNAGLRLDGFQAGTVALTIYTSAFIA EAIRAGIQSVSKGQMEAARSSGFTYSQAMLHIILPQAIKIVIPPLGNQFLNLVKNSSI LGVVAGLDLMYQADLVSSSTLVVFDVYIFVALFYLVLTIPLSIGVNYLEKRLEKSY*" /label="glnM CDS" gene 2300762..2301412 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /label="glnM gene" CDS 2301429..2302085 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390623.1" /db_xref="EnsemblGenomes-Gn:BSU27460" /db_xref="EnsemblGenomes-Tr:CAB14687" /db_xref="GOA:O34606" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11488" /db_xref="UniProtKB/Swiss-Prot:O34606" /translation="MDFIGAYSQEHLAFLWDGFLVTLYVAFISIILSFFFGLIAGTLR YAKVPVLSQLIAVLVETIRNLPLLLIIFFTFFALPEIGIKLEITAAAITALTIFESAM LSEIIRSGLKSIDKGQIEAARSSGLSYTQTLFFIVMPQALRRMVPPIVSQFISLLKDT SLAVVIALPELIHNAQIINGQSADGSYFFPIFLLAALMYFAVNYSLSLAARRLEVRQT *" /label="glnP CDS" gene 2301429..2302085 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /label="glnP gene" downshifts 2302084 /Source="Nicolas_upshifts" /id="D1403" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.21558" /MaxDrop="6.08472" /score="5.38937989" /energy="-11.7" /TU="NA" /idTUdmin="U2116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2302120..2302251) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097766.1" /db_xref="EnsemblGenomes-Gn:BSU27468" /db_xref="EnsemblGenomes-Tr:CAX52672" /db_xref="InterPro:IPR025029" /db_xref="UniProtKB/Swiss-Prot:C0H461" /translation="MNRTMTSLLAMGAGALVYRMATQSDMLNNRSMKRMRRRITKMF* " /label="yrzQ CDS" gene complement(2302120..2302251) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /label="yrzQ gene" downshifts complement(2302138) /Source="Nicolas_upshifts" /id="D1404" /incds=0 /nref=50 /ntot=77 /MaxReadThrough="1.58565" /MaxDrop="8.21989" /score="5.69801689" /energy="-11.7" /TU="NA" /idTUdmin="U2118" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2302273..2302464) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097767.1" /db_xref="EnsemblGenomes-Gn:BSU27469" /db_xref="EnsemblGenomes-Tr:CAX52673" /db_xref="UniProtKB/Swiss-Prot:C0H462" /translation="MLICPNCKSKDIGKIGVNQYYCWGCFIELTVAKGKIATHQVEED GTLSSLDDLFSEDERSINF*" /label="yrzR CDS" gene complement(2302273..2302464) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /label="yrzR gene" CDS complement(2302476..2303000) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390624.1" /db_xref="EnsemblGenomes-Gn:BSU27470" /db_xref="EnsemblGenomes-Tr:CAB14688" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13790" /db_xref="UniProtKB/Swiss-Prot:O34402" /translation="MSLRRKAKPKPVQQKVVDHTLRTCHEVEGFPVYSERTSSYLGTI SDICFSLKGDCLGFILAQKRFLHHHHALLRACDISSIFDDRILASVSSEQLLPLPKSC FTYEQMKMKLVKSQEGDILGMLEDVYFCLDRGIIVAYELSDGFFSDLAGSKRQIQRAD SLVEVRKDEIVLNG*" /label="yrrD CDS" gene complement(2302476..2303000) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /label="yrrD gene" upshifts complement(2302587) /Source="Nicolas_upshifts" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2302591..2302602) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2302617..2302623) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2302971..2302982) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2302977) /Source="Nicolas_upshifts" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2302997..2303003) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2303058..2305454) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /EC_number="3.1.11.5" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3537961, 11557815, 21170359, 22720735, 24443534, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3537961, 11557815, 21170359, 22720735, 24443534, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5'-3' helicase associated to SSB; exonuclease V" /protein_id="NP_390625.1" /db_xref="EnsemblGenomes-Gn:BSU27480" /db_xref="EnsemblGenomes-Tr:CAB14689" /db_xref="GOA:O34481" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR006345" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="InterPro:IPR029493" /db_xref="SubtiList:BG13789" /db_xref="UniProtKB/Swiss-Prot:O34481" /translation="MQQHPDQLKLEEEPYLKGTVNTVIYHNDTNLYTVLKVKVTETSE AIEDKAVSVTGYFPALQEEETYTFYGKIVTHPKFGLQFQAEHFKKEIPTTKEGIIQYL SSDLFEGIGKKTAEEIVKKLGDSAINKILADASVLYDVPRLSKKKADTLAGALQRHQG LEQIMISLNQFGFGPQLSMKIYQAYESETLEKIQENPYQLVKDVEGIGFGKADELGSR MGLSGNHPERVKAAILYTLETTCLSEGHTYIETEQLIIDTQSLLNQSAREGQRITEMD AANAIIALGENKDIVIEDGRCYFPSLFYAEQNVAKRVKHIASQTEYENQFPESEFLLA LGELEERMDVQYAPSQKEAIQKALSSPMLLLTGGPGTGKTTVIRGIVELYGELHGVSL DPSAYKKDEAFPIVLAAPTGRAAKRMSESTGLPAVTIHRLLGWNGAEGFTHTEDQPIE GKLLIIDEASMLDIWLANHLFKAIPDHIQIIIVGDEDQLPSVGPGQVLRDLLASQVIP TVRLTDIYRQAEGSSIVELAHQMKNGLLPNNLTAPTKDRSFIRCGGSQIKEVVEKVVA NALKKGYTAKDIQVLAPMYRGKAGINELNVMLQDILNPPKEKRRELKFGDVVYRTGDK ILQLVNQPENNVFNGDIGEITSIFYAKENTEKEDMAVVSFDGNEMTFTKKDFNQFTHA YCCSIHKSQGSEFPIVVLPVVKGYYRMLRRNLLYTAITRAKKFLILCGEEEALEWGVK NNDATVRQTSLKNRLSVQVEEMDAELEALQKELPFSVHDANIGMEGITPFDFMKEEQQ *" /label="recDB CDS" gene complement(2303058..2305454) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /label="recDB gene" downshifts complement(2303084) /Source="Nicolas_upshifts" /id="D1405" /incds=0 /nref=32 /ntot=211 /MaxReadThrough="2.07603" /MaxDrop="3.57113" /score="41.0323102" /energy="-10.8" /TU="NA" /idTUdmin="U2121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2303304..2303310 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2303318 /Source="Nicolas_upshifts" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2303325..2303336 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2303338..2303687 /Source="Nicolas_S_feature" /locus_tag="new_2806566_2806915" /HighExp="S8, S5, S6, S7, S4, C30, nit, ferm, G135, T5.0H" /AntisenseName="yrrC" /AntisenseCor="-0.46935785055870999" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1042" downshifts complement(2303439) /Source="Nicolas_upshifts" /id="D1406" /incds=1 /nref=16 /ntot=163 /MaxReadThrough="4.93428" /MaxDrop="2.86437" /score="41.0323102" /energy="-10.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-355" /isTUend="FALSE" /label="downshifts" CDS complement(2305479..2306099) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11777911, 12594026, 18180259; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative tetratricopeptide repeat family protein" /protein_id="NP_390626.1" /db_xref="EnsemblGenomes-Gn:BSU27490" /db_xref="EnsemblGenomes-Tr:CAB14690" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR013105" /db_xref="InterPro:IPR019734" /db_xref="PDB:2Q7F" /db_xref="SubtiList:BG13788" /db_xref="UniProtKB/Swiss-Prot:O34452" /translation="MQEGDYEKAAEAFTKAIEENKEDAIPYINFANLLSSVNELERAL AFYDKALELDSSAATAYYGAGNVYVVKEMYKEAKDMFEKALRAGMENGDLFYMLGTVL VKLEQPKLALPYLQRAVELNENDTEARFQFGMCLANEGMLDEALSQFAAVTEQDPGHA DAFYNAGVTYAYKENREKALEMLDKAIDIQPDHMLALHAKKLIDPS*" /label="yrrB CDS" gene complement(2305479..2306099) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /label="yrrB gene" CDS complement(2306185..2307300) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /EC_number="2.8.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-specific 2-thiouridylase" /protein_id="NP_390627.3" /db_xref="EnsemblGenomes-Gn:BSU27500" /db_xref="EnsemblGenomes-Tr:CAB14691" /db_xref="GOA:O35020" /db_xref="InterPro:IPR004506" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023382" /db_xref="SubtiList:BG13787" /db_xref="UniProtKB/Swiss-Prot:O35020" /translation="MEKRPEDTRVVVGMSGGVDSSVAALLLKEQGYDVIGIFMKNWDD TDENGFCTATEDYEDVIRVCNQIGIPYYAVNFEKQYYEKVFQYFLDEYKAGRTPNPDV LCNKEIKFKAFLEHALSLGADYLATGHYARVDRSGGKVRMLRGIDENKDQTYFLNQLT EDTLSKVMFPIGELQKSRVREIAKEAELATATKKDSTGICFIGERNFKTFLSQYLPAQ PGDMMTMDGEVKGRHDGLMYYTIGQRHGLGIGGSGEPWFAVGKDLEKNILYVDQGFHN PLLYSDKITATNISWVRSDIMKGEEISCTAKFRYRQEDHKVTVRMTGEGEAEVIFDEQ VRAVTPGQAVVFYDGEECLGGGTIDDVYKDGTKLWYV*" /label="mnmA CDS" gene complement(2306185..2307300) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /label="mnmA gene" downshifts complement(2306186) /Source="Nicolas_upshifts" /id="D1407" /incds=0 /nref=2 /ntot=69 /MaxReadThrough="6.45399" /MaxDrop="4.31641" /score="2.49091848" /energy="-7.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" CDS complement(2307331..2308470) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496536, 10930739, 12682299, 17064282, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496536, 10930739, 12682299, 17064282, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase involved in U34 tRNA thiolation" /protein_id="NP_390629.2" /db_xref="EnsemblGenomes-Gn:BSU27510" /db_xref="EnsemblGenomes-Tr:CAB14693" /db_xref="GOA:O34599" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG13809" /db_xref="UniProtKB/Swiss-Prot:O34599" /translation="MERIYLDHAATSPMDERVLEQMIPHFSGSFGNPSSIHSFGRESR KWVDEARAQIAAEIGAAEQEIIFTSGGTEADNLAIMGTALARKDLGRHIITTKIEHHA VLHTCEKLEGDGFDITYLDVDQNGRVSAKQVKEALRDDTILVTVMYGNNEVGTVQPIE EIGELLKEHKAYFHTDAVQAFGLLPIDVKNSHIDLLSVSGHKLNGPKGTGFLYASKDV KLSPLLFGGEQERKRRAGTENVPGIVGLKEAIKLSSEERDEKNEKYQSFKAIFADTLR DAGVAFEVNGDKEHSLPHVLNLYFPGVSVEALLVNLDMAGVAVSSGSACTAGSVLPSH VLTAMFGEESDRLTSSIRISFGLGNTAEQVKTAAKHVADVVKRLT*" /label="iscSA CDS" gene complement(2307331..2308470) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /label="iscSA gene" promotor_-10 complement(2308037..2308056) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2308049) /Source="Nicolas_upshifts" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2308070..2308077) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2308489..2308905) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of cysteine biosynthesis" /protein_id="NP_390630.2" /db_xref="EnsemblGenomes-Gn:BSU27520" /db_xref="EnsemblGenomes-Tr:CAB14694" /db_xref="GOA:O34527" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2Y75" /db_xref="SubtiList:BG13813" /db_xref="UniProtKB/Swiss-Prot:O34527" /translation="MKISTKGRYGLTIMIELAKKHGEGPTSLKSIAQTNNLSEHYLEQ LVSPLRNAGLVKSIRGAYGGYVLGSEPDAITAGDIIRVLEGPISPVEVLEDEEPAKRE LWIRIRDAVKEVLDSTTLEDLASYTDGEQEAYMFYI*" /label="cymR CDS" gene complement(2308489..2308905) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /label="cymR gene" S_feature complement(2308906..2309003) /Source="Nicolas_S_feature" /locus_tag="new_2812134_2812231_c" /HighExp="Cold, T3.0H, G135, LBGexp, G180, G150, Salt, Lbexp, H2O2, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1043" promotor_-10 complement(2308988..2309007) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2309003) /Source="Nicolas_upshifts" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2309023..2309026) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2309051..2309058 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2309072..2309091 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2309080 /Source="Nicolas_upshifts" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="upshifts" CDS 2309108..2310373 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15743409, 17641684, 21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743409, 17641684, 21170359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-dependent ATPase active at replication forks" /protein_id="NP_390631.1" /db_xref="EnsemblGenomes-Gn:BSU27530" /db_xref="EnsemblGenomes-Tr:CAB14695" /db_xref="GOA:O34528" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR021886" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032423" /db_xref="SubtiList:BG13808" /db_xref="UniProtKB/Swiss-Prot:O34528" /translation="MKPLAYRMRPTKIEDIIGQQHLVAEDKIIGRMVQAKHLSSMILY GPPGIGKTSIATAIAGSTSIAFRKLNAVINNKKDMEIVAQEAKMSGQVILILDEVHRL DKGKQDFLLPYLENGMIILIGATTANPYHAINPAIRSRTQIFELEPLTPELIKQALER ALHDEHRGLGTYSVSIDDQAMEHFAHGCGGDVRSALNALELAVLSTKESADGEIHITL ETAEECLQKKSFSHDKDGDAHYDVLSAFQKSIRGSDANAALHYLARLIEAGDLESIAR RLLVIAYEDIGLASPQAGPRVLNAIQTAERVGFPEARIPLANAVIELCLSPKSNSAIL AIDEALADIRAGKIGDVPKHLKDAHYKGAQELGRGIDYKYPHNYDNGWVEQQYLPDPL KNKQYYKPKQTGKFESALKQVYDKLMKRK*" /label="rarA CDS" gene 2309108..2310373 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /label="rarA gene" downshifts 2310372 /Source="Nicolas_upshifts" /id="D1408" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="1.09429" /MaxDrop="4.5261" /score="14.6665846" /energy="-12" /TU="NA" /idTUdmin="U2123" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2310415..2311179) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /EC_number="6.1.-.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12177353, 20097860, 23242255, 27913733, 28671653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA threonylcarbamoyladenosine dehydratase (t(6)A37 dehydratase)" /protein_id="NP_390632.3" /db_xref="EnsemblGenomes-Gn:BSU27540" /db_xref="EnsemblGenomes-Tr:CAB14713" /db_xref="GOA:O32037" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13807" /db_xref="UniProtKB/Swiss-Prot:O32037" /translation="MLHQFSRNELAIGKEGLETLKNSTVAVLGVGGVGSFAAEALARS GVGRILLVDKDDVDITNVNRQLHALLSTVGQPKVDLMKARIADINPECEVIALKMFYT EETYEQFFDYGLDYVIDASDTICYKIHLMKECLKRDIPLISSMGAANKTDPTRFQIAD ISKTHTDPIAKVVRTKLRKEGIKKGVQVIFSDESPIVIREDVRKEVGNDEAKIRKAKM PPSSNAFVPSVAGLIMGGHVVMDLLKDIEIKRVKDK*" /label="tcdA CDS" gene complement(2310415..2311179) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /label="tcdA gene" downshifts complement(2310433) /Source="Nicolas_upshifts" /id="D1409" /incds=0 /nref=246 /ntot=264 /MaxReadThrough="2.35294" /MaxDrop="7.20309" /score="44.7253801" /energy="-12" /TU="NA" /idTUdmin="U2125" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(2311263..2311463) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /product="6Sb RNA" /experiment="publication(s) with functional evidences, PMID:12177353, 15793584, 15811922, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 15793584, 15811922, 25576829, 26873600; Product type n: RNA" /label="ssrSB RNA" gene complement(2311263..2311463) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /label="ssrSB gene" downshifts complement(2311281) /Source="Nicolas_upshifts" /id="D1410" /incds=0 /nref=81 /ntot=303 /MaxReadThrough="7.44881" /MaxDrop="6.73892" /score="44.7253801" /energy="-12" /TU="U2125,U2127" /idTUdmin="U2125" /TUdmin="-848" /isTUend="FALSE" /label="downshifts" upshifts 2311450 /Source="Nicolas_upshifts" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2311451..2311460 /Source="Nicolas_upshift_promotors" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2311461..2311480) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2311472) /Source="Nicolas_upshifts" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2311493..2311500) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2311515..2313293) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /EC_number="6.1.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12177353, 26804570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartyl-tRNA synthetase, promiscuous (also recognizes tRNAasn)" /protein_id="NP_390633.1" /db_xref="EnsemblGenomes-Gn:BSU27550" /db_xref="EnsemblGenomes-Tr:CAB14714" /db_xref="GOA:O32038" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004115" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004524" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029351" /db_xref="SubtiList:BG12572" /db_xref="UniProtKB/Swiss-Prot:O32038" /translation="MFGRTYYCGDITEKAIGESVTLKGWVQKRRDLGGLIFIDLRDRT GIVQVVFNPDVSKEALAIAEGIRNEYVLDIQGKVVAREEGTVNPNLKTGAIEIHADGV NVLNAAKTPPFAISDQAEEVSEDVRLKHRYLDLRRPAMFQTMQLRHNVTKAVRSFLDE NGFLDIETPILTGSTPEGARDYLVPSRVHEGEFYALPQSPQLFKQLLMVSGIERYYQI ARCFRDEDLRADRQPEFTQIDIEMSFMSQEDIMSLAEEMMAKVMRETKGEELQLPLPR MTYDEAMNKYGSDKPDTRFDMLLTDVSDIVKDTEFKVFSSAVANGGVVKAINVKGGAG DYSRKDIDALGAFAANYGAKGLAWVKVEADGVKGPIAKFFDEEKQSKLIEALDAAEGD LLLFGADQFEVVAASLGALRLKLGKERGLIDEKLFNFLWVIDWPLLEHDPEEGRFYAA HHPFTMPVREDLELIETAPEDMKAQAYDLVLNGYELGGGSIRIFEKDIQEKMFALLGF SPEEAAEQFGFLLEAFEYGAPPHGGIALGLDRLVMLLAGRTNLRDTIAFPKTASASCL MTEAPGEVSDAQLDELHLSIKKKVKN*" /label="aspS CDS" gene complement(2311515..2313293) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /label="aspS gene" CDS complement(2313307..2314581) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /EC_number="6.1.1.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28321488; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase" /protein_id="NP_390634.1" /db_xref="EnsemblGenomes-Gn:BSU27560" /db_xref="EnsemblGenomes-Tr:CAB14715" /db_xref="GOA:O32039" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR015807" /db_xref="InterPro:IPR033656" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG12605" /db_xref="UniProtKB/Swiss-Prot:O32039" /translation="MGYNIPRGTQDILPGESDRWQFVEQIMRDTCRTYQYKEIRTPIF EHTELFARGVGESTDIVQKEMYTFEDRKGRSLTLRPEGTAAAVRAFNENKLFANPVQP TKLYYVGPMFRYERPQTGRYRQFYQFGIEAIGSKDPAIDAEVMALAMSIYEKAGLENV KLVINSLGDQDSRKSYREALVKHFEPRIEEFCSDCQSRLHTNPLRILDCKKDRDHELM KSAPSILTYLNEESAAYFEKVKQYLNDLGISYEIDPNLVRGLDYYNHTAFEIMSNAEG FGAITTLAGGGRYDGLVEQIGGPEAPGIGFAMSIERLLAAIDAEKRELPVDKGIDCYI VTLGEKAKDYSVSLVYKLREAGISSEIDYENKKMKGQFKTADRLKARFIAILGEDELA QNKINVKDAQTGEQIEVALDEFIHVMKANQKG*" /label="hisS CDS" gene complement(2313307..2314581) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /label="hisS gene" misc_RNA complement(2314671..2314903) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /product="T-box riboswitch controlling synthesis of histidine and aspartate tRNA ligases" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.3: Control" /label="tboH RNA" gene complement(2314671..2314903) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /label="tboH gene" downshifts complement(2314701) /Source="Nicolas_upshifts" /id="D1411" /incds=0 /nref=71 /ntot=180 /MaxReadThrough="7.0761" /MaxDrop="5.61082" /score="40.6097692" /energy="-23.7" /TU="U2127" /idTUdmin="U2128" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2314913..2314916 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2314927..2314946) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2314931..2314950 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2314933..2315217 /Source="Nicolas_S_feature" /locus_tag="new_2818161_2818445" /HighExp="H2O2, G135, G180, C30, G150, Paraq, Oxctl, dia15, LBGstat, LBGexp" /AntisenseName="yrzK" /AntisenseCor="-0.27832941694878799" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1044" upshifts 2314933 /Source="Nicolas_upshifts" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2314946) /Source="Nicolas_upshifts" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2314961..2314968) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2314963..2315133) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390635.1" /db_xref="EnsemblGenomes-Gn:BSU27570" /db_xref="EnsemblGenomes-Tr:CAB14716" /db_xref="InterPro:IPR035378" /db_xref="SubtiList:BG13820" /db_xref="UniProtKB/Swiss-Prot:O32040" /translation="MKYHPKMGRAFHDGEANLHYSDHADPDTTGYLTETASEFGLMSK EAALRKNNRNKA*" /label="yrzK CDS" gene complement(2314963..2315133) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /label="yrzK gene" promotor_-10 complement(2315164..2315175) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-10" upshifts complement(2315181) /Source="Nicolas_upshifts" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="upshifts" promotor_-35 complement(2315190..2315196) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-35" promotor_-35 2315193..2315200 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2315214..2315232 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2315219 /Source="Nicolas_upshifts" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2315266..2316822 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /EC_number="3.5.1.28" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetylmuramoyl-L-alanine amidase, family 3" /protein_id="NP_390636.1" /db_xref="EnsemblGenomes-Gn:BSU27580" /db_xref="EnsemblGenomes-Tr:CAB14717" /db_xref="GOA:O32041" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR017293" /db_xref="SubtiList:BG13806" /db_xref="UniProtKB/Swiss-Prot:O32041" /translation="MNKKYFVLIVCIIFTSALFPTFSSVTAAQGEAVIATDEMNVRSG PGLSYGITAEVKKGERYPILKEDGDWVQIQLGSGEKGWVVSWLITKEDQASTSSSGSS DTVTSTDPDLRMRSGPGTSYEVIGKFPQGSQASVIDKDSGWIKISYHSATGWVSSEYV TSGGSSSASDESDQTEDSGASTTGTVGVSSLNVRASASHDAAIITKLDRGTKLTVLNE KNGWAHIEVNGLKGWVASHYLLTSSVPADDSANAGSSSSAKKAYIMYGGTNLRSDAST SASIVERAAKGDSYTITGSKGSWYEIKLDNGQTAYVANWVVQTSKSAEEAGEPPVSDS PSGNGSLNNKTIIVDPGHGGKDSGTIGYSGKFEKNLTIKTAKLLASKLRSAGADVYVT RQDDTFVSLQSRVSTSHYRNADAFISIHYDSYADTSTRGSTAYYYSPAKDQELASDVH SEVVKRSSIPDRGVLFGDYYVLRENRQPAMLYELGYVSHPQEEAIVHSNSYQEKVTDG IESGLEKYFQ*" /label="yrvJ CDS" gene 2315266..2316822 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /label="yrvJ gene" downshifts 2316801 /Source="Nicolas_upshifts" /id="D1412" /incds=0 /nref=199 /ntot=249 /MaxReadThrough="2.10072" /MaxDrop="7.40599" /score="44.9570925" /energy="-9.9" /TU="U2126" /idTUdmin="U2129" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2316849..2317247) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15292242, 15525705, 16844682, 18700836, 28362257; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gly-tRNA(Ala) deacylase / D-Tyr-tRNATyr deacylase" /protein_id="NP_390637.2" /db_xref="EnsemblGenomes-Gn:BSU27590" /db_xref="EnsemblGenomes-Tr:CAB14718" /db_xref="GOA:O32042" /db_xref="InterPro:IPR003732" /db_xref="InterPro:IPR023509" /db_xref="SubtiList:BG13805" /db_xref="UniProtKB/Swiss-Prot:O32042" /translation="MDEEVVGQIGQGLMVLVGITHDDTEDDAAYLADKVVNLRIFDDS EGKMNLSLVDIGGEILSVSQFTLYGDTKKGRRPNYMNAAKPDKALGLYEKWNDLLREK GIKVETGTFGAMMDVQLTNSGPVTLIMDSK*" /label="dtd CDS" gene complement(2316849..2317247) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /label="dtd gene" downshifts complement(2316857) /Source="Nicolas_upshifts" /id="D1413" /incds=0 /nref=152 /ntot=267 /MaxReadThrough="2.01735" /MaxDrop="9.47739" /score="37.3693259" /energy="-9.9" /TU="NA" /idTUdmin="U2130" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2317301..2319505) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /EC_number="2.7.6.5" /EC_number="3.1.7.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTP pyrophosphokinase (RelA/SpoT)" /protein_id="NP_390638.2" /db_xref="EnsemblGenomes-Gn:BSU27600" /db_xref="EnsemblGenomes-Tr:CAB14719" /db_xref="GOA:O54408" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004811" /db_xref="InterPro:IPR007685" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR033655" /db_xref="SubtiList:BG12665" /db_xref="UniProtKB/Swiss-Prot:O54408" /translation="MANEQVLTAEQVIDKARSYLSDEHIAFVEKAYLYAEDAHREQYR KSGEPYIIHPIQVAGILVDLEMDPSTIAGGFLHDVVEDTDVTLDDLKEAFSEEVAMLV DGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ RRISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYV DEVVNEVKKRVEEVNIKADFSGRPKHIYSIYRKMVLQNKQFNEIYDLLAVRILVNSIK DCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKGDPLEVQIRTFEMHE IAEYGVAAHWAYKEGKAANEGATFEKKLSWFREILEFQNESTDAEEFMESLKIDLFSD MVYVFTPKGDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDHKLRTGDIVE ILTSKHSYGPSQDWVKLAQTSQAKHKIRQFFKKQRREENVEKGRELVEKEIKNLDFEL KDVLTPENIQKVADKFNFSNEEDMYAAVGYNGITALQVANRLTEKERKQRDQEEQEKI VQEVTGEPKPYPQGRKREAGVRVKGIDNLLVRLSKCCNPVPGDDIVGFITKGRGVSVH REDCPNVKTNEAQERLIPVEWEHESQVQKRKEYNVEIEILGYDRRGLLNEVLQAVNET KTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERIKQIRDIYSVRRVMN*" /label="rsh CDS" gene complement(2317301..2319505) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /label="rsh gene" promotor_-10 complement(2319534..2319553) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2319541) /Source="Nicolas_upshifts" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2319543..2319633) /Source="Nicolas_S_feature" /locus_tag="new_2822771_2822861_c" /HighExp="Cold, G135, G180, G150, H2O2, Paraq, Oxctl, C30, LBGexp, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="0.951, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 1" /label="S1045" promotor_-35 complement(2319568..2319575) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2319597 /Source="Nicolas_upshifts" /id="D1414" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.75679" /MaxDrop="3.54336" /score="0.486890657" /energy="-12.7" /TU="NA" /idTUdmin="U2126" /TUdmin=2772 /isTUend="FALSE" /label="downshifts" CDS complement(2319673..2320185) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /EC_number="2.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 9383190, 15629952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 9383190, 15629952; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine phosphoribosyltransferase" /protein_id="NP_390639.1" /db_xref="EnsemblGenomes-Gn:BSU27610" /db_xref="EnsemblGenomes-Tr:CAB14720" /db_xref="GOA:O34443" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005764" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG12568" /db_xref="UniProtKB/Swiss-Prot:O34443" /translation="MDLKQYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYA KEKQIDLVVGPEARGFIIGCPVAYALGVGFAPVRKEGKLPREVIKVDYGLEYGKDVLT IHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRNKLE DYDILTLMKY*" /label="apt CDS" gene complement(2319673..2320185) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /label="apt gene" downshifts complement(2319678) /Source="Nicolas_upshifts" /id="D1415" /incds=0 /nref=39 /ntot=228 /MaxReadThrough="5.36411" /MaxDrop="4.05036" /score="2.83935873" /energy="-6.8" /TU="U2131,U2132,U2133" /idTUdmin="U2131" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" CDS complement(2320191..2322551) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21087930, 21170359, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21087930, 21170359, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="single-strand DNA-specific exonuclease" /protein_id="NP_390640.1" /db_xref="EnsemblGenomes-Gn:BSU27620" /db_xref="EnsemblGenomes-Tr:CAB14721" /db_xref="GOA:O32044" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR004610" /db_xref="InterPro:IPR018779" /db_xref="SubtiList:BG13804" /db_xref="UniProtKB/Swiss-Prot:O32044" /translation="MLASKMRWEIQRPDQDKVKSLTEQLHITPLVASLLVKRGFDTAE SARLFLHTKDADFYDPFEMKGMKEAADRIKQAISQQEKIMIYGDYDADGVTSTSVMLH TLQKLSAQVDFYIPDRFKEGYGPNEQAFRSIKERGFSLIITVDTGIAAVHEAKVAKEL GLDVIITDHHEPGPELPDVRAIVHPKQPGCTYPFKELAGVGVAFKLAHALLGELPDEL LDLAAIGTIADLVPLHDENRLIATLGLERLRRTNRLGLKELIKLSGGDIGEANEETVG FQLAPRLNAVGRIEQADPAVHLLMSEDSFEAEELAAEIDQLNKERQKMVSKMTDEAIE MVEQQGLDQTAIVVAKAGWNPGVVGIVASKLVDRFYRPAIVLGIDEEKGIAKGSARSI RGFNLFESLSECRDILPHFGGHPMAAGMTLKAEDVPDLRSRLNEIADNTLTEEDFIPV QEVDLVCGVEDITVESIAEMNMLSPFGMLNPKPHVLVENAVLEDVRKIGANKTHVKMT IRNESSQLDCVGFNKGELQEGIVPGSRISIVGEMSINEWNNRKKPQLMIKDAAVSEWQ LFDLRGKRTWEDTVSALPSAKRAIVSFKEDSTTLLQTEDLRREVHVISSKDQAKAFDL DGAYIVLLDPPPSLDMLARLLEGKAPERIYFIFLNHEDHFLSTFPARDHFKWYYAFLL KRGAFDVKKHGSELAKHKGWSVETINFMTKVFFDLGFVKIENGVLSVVSGAKKRDLTD SQTYQAKQQLMELDQKLNYSSAEELKEWLNKLMKQDSEAYESTRRT*" /label="recJ CDS" gene complement(2320191..2322551) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /label="recJ gene" promotor_-10 complement(2320655..2320674) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2320663) /Source="Nicolas_upshifts" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2320688..2320697) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-35" promotor_-10 complement(2322565..2322584) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2322576) /Source="Nicolas_upshifts" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2322599..2322605) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2322618..2322941) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390641.1" /db_xref="EnsemblGenomes-Gn:BSU27630" /db_xref="EnsemblGenomes-Tr:CAB14722" /db_xref="GOA:O32045" /db_xref="InterPro:IPR010445" /db_xref="SubtiList:BG13803" /db_xref="UniProtKB/Swiss-Prot:O32045" /translation="MNKQWTIIFALIFTLIVAIFAVINVRSVEVDYLFGRSEWPLILV ILGSVLMGALIVFSVGIFQVMKLKREIKTLRKENRTAIHKQEDTHLADQTDTQDASAM IEKKD*" /label="yrvD CDS" gene complement(2322618..2322941) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /label="yrvD gene" promotor_-10 complement(2322962..2322980) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2322973) /Source="Nicolas_upshifts" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2322995..2323001) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-35" CDS complement(2323017..2323514) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative potassium transport accessory component" /protein_id="NP_390642.1" /db_xref="EnsemblGenomes-Gn:BSU27640" /db_xref="EnsemblGenomes-Tr:CAB14723" /db_xref="GOA:O32046" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13802" /db_xref="UniProtKB/Swiss-Prot:O32046" /translation="MRVRESELPGIGQKVEMITRNRDKISIIIHHDGRRELYYFDEND HEECVASVQFDDAEARQMSAILGGMAYKPKALEQVESALDDLIIEWCKAEAGAPAIHQ TIGDLNVGQEYHVTVIAIVKKNQDKQLNPSSETVIDEGDTLVISGEGTGLKRLIREKL TAKGA*" /label="yrvC CDS" gene complement(2323017..2323514) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /label="yrvC gene" S_feature complement(2323515..2323590) /Source="Nicolas_S_feature" /locus_tag="new_2826743_2826818_c" /HighExp="Oxctl, HiOs, G180, LBGexp, Paraq, G150, G135, H2O2, MG-0.2, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1046" promotor_-10 complement(2323584..2323603) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-10" upshifts complement(2323590) /Source="Nicolas_upshifts" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="upshifts" promotor_-35 complement(2323617..2323624) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-35" CDS complement(2323672..2325885) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9694879, 15941986, 15995216, 16517687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9694879, 15941986, 15995216, 16517687; Product type t: transporter" /codon_start=1 /transl_table=11 /product="protein-export membrane protein" /protein_id="NP_390643.1" /db_xref="EnsemblGenomes-Gn:BSU27650" /db_xref="EnsemblGenomes-Tr:CAB14724" /db_xref="GOA:O32047" /db_xref="InterPro:IPR005665" /db_xref="InterPro:IPR005791" /db_xref="InterPro:IPR022645" /db_xref="InterPro:IPR022646" /db_xref="InterPro:IPR022813" /db_xref="SubtiList:BG12672" /db_xref="UniProtKB/Swiss-Prot:O32047" /translation="MKKGRLIAFFLFVLLIGTGLGYFTKPAANNITLGLDLQGGFEVL YDVQPVKKGDKITKDVLVSTVEALNRRANVLGVSEPNIQIEGNNRIRVQLAGVTNQNR AREILATEAQLSFRDANDKELLNGADLVENGAKQTYDSTTNEPIVTIKLKDADKFGEV TKKVMKMAPNNQLVIWLDYDKGDSFKKEVQKEHPKFVSAPNVSQELNTTDVKIEGHFT AQEAKDLASILNAGALPVKLTEKYSTSVGAQFGQQALHDTVFAGIVGIAIIFLFMLFY YRLPGLIAVITLSVYIYITLQIFDWMNAVLTLPGIAALILGVGMAVDANIITYERIKE ELKLGKSVRSAFRSGNRRSFATIFDANITTIIAAVVLFIFGTSSVKGFATMLILSILT SFITAVFLSRFLLALLVESRWLDRKKGWFGVNKKHIMDIQDTDENTEPHTPFQKWDFT SKRKYFFIFSSAVTVAGIIILLVFRLNLGIDFASGARIEVQSDHKLTTEQVEKDFESL GMDPDTVVLSGEKSNIGVARFVGVPDKETIAKVKTYFKDKYGSDPNVSTVSPTVGKEL ARNALYAVAIASIGIIIYVSIRFEYKMAIAAIASLLYDAFFIVTFFSITRLEVDVTFI AAILTIIGYSINDTIVTFDRVREHMKKRKPKTFADLNHIVNLSLQQTFTRSINTVLTV VIVVVTLLIFGASSITNFSIALLVGLLTGVYSSLYIAAQIWLAWKGRELKKDSAQ*" /label="secDF CDS" gene complement(2323672..2325885) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /label="secDF gene" downshifts complement(2323677) /Source="Nicolas_upshifts" /id="D1416" /incds=0 /nref=174 /ntot=249 /MaxReadThrough="4.49738" /MaxDrop="5.0013" /score="29.1843057" /energy="-17.8" /TU="U2137" /idTUdmin="U2137" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" promotor_-35 2325444..2325449 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2325463..2325482 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2325471 /Source="Nicolas_upshifts" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2325924..2326220) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19028902, 27059541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19028902, 27059541; Product type r: regulator" /codon_start=1 /transl_table=11 /product="post-transcriptional regulator" /protein_id="NP_390644.1" /db_xref="EnsemblGenomes-Gn:BSU27660" /db_xref="EnsemblGenomes-Tr:CAB14726" /db_xref="GOA:O32049" /db_xref="InterPro:IPR025716" /db_xref="SubtiList:BG13814" /db_xref="UniProtKB/Swiss-Prot:O32049" /translation="MEKHPADLYKDHVRPFLYSKLEEFKILGYDDVELESLWSYLTDK KWKKKTELSIYELASDILSVKIGEFMNYATVESFKTSNWLGSEEGQEALEELLR*" /label="comN CDS" gene complement(2325924..2326220) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /label="comN gene" downshifts 2326131 /Source="Nicolas_upshifts" /id="D1417" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.36122" /MaxDrop="2.33158" /score="-9.07145122" /energy="-8.4" /TU="NA" /idTUdmin="U2136" /TUdmin="-2508" /isTUend="FALSE" /label="downshifts" S_feature complement(2326221..2326299) /Source="Nicolas_S_feature" /locus_tag="new_2829449_2829527_c" /HighExp="LBGtran, Lbtran, C90, M40t45, HiOs, Lbexp, Cold, M0t45, UNK1, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigH" /TUlongPSig=1 /label="S1047" promotor_-35 2326261..2326266 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-35" promotor_-10 2326283..2326301 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-10" promotor_-10 complement(2326285..2326304) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-10" upshifts 2326285 /Source="Nicolas_upshifts" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="upshifts" upshifts complement(2326299) /Source="Nicolas_upshifts" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="upshifts" S_feature complement(2326301..2327219) /Source="Nicolas_S_feature" /locus_tag="new_2829529_2830447_c" /HighExp="S2, M9-stat, Lbstat, BC, T2.0H, T3.0H, T2.30H, T3.30H, Cold, M0t90" /AntisenseName="spoVB" /AntisenseCor="-8.5173616652496897E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1048" promotor_-35 complement(2326319..2326322) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-35" CDS 2326336..2327892 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1744050, 15292147, 15849754, 16850406, 17714441, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744050, 15292147, 15849754, 16850406, 17714441, 19648239; Product type t : transporter" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation); translocase with flippase function for peptidoglycan synthesis" /protein_id="NP_390645.1" /db_xref="EnsemblGenomes-Gn:BSU27670" /db_xref="EnsemblGenomes-Tr:CAB14727" /db_xref="GOA:Q00758" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR014249" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10778" /db_xref="UniProtKB/Swiss-Prot:Q00758" /translation="MAKQTFLKGTLILIAAGMVTRMLGFVNRVVIARFIGEEGVGLYM MAAPTFFLATTLTQFGLPVAISKLVAEASARGDHQKTKNILVMSLTITGVLSLIFTPL FLFFAPVMAETMLTDKRTLYPLLAITPVVPIIAISSVLRGYFQGKQNMNPLAMSQVLE QVVRISLVAVCTTIFLPYGIEYAAAGAMLSSVAGELASLLYLFVCFKYKKTIKIRKHF LQSIKNGKQTFTQLMSVSLPTTGSRFIGNLSWFFEPIVVAQSLAIAGVATVAATKQYG ELTGFAMTLLTLPSFITYSLSTALVPAISEGMEQKKLQVVEYRLEQAMRLCLLSGGIS VVILFVFADELMRVMYGSSGAAVFIKVMAPFFLLYYFQGPLQAVLQALNLAGAAMMNS LIGALVKTGLIFVLATRPSLGIMGAALAIVTGMVLVTLLHAATVSKVLPISIKIKEYA LSFAVIVICGFISSAIKQYISFGASEAVNLAGWIAASAAIYMILLLVFRLIKKDELRR IPIIGRLIIR*" /label="spoVB CDS" gene 2326336..2327892 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /label="spoVB gene" promotor_-10 complement(2327205..2327223) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-10" upshifts complement(2327219) /Source="Nicolas_upshifts" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="upshifts" promotor_-35 complement(2327235..2327243) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-35" S_feature 2327893..2328657 /Source="Nicolas_S_feature" /locus_tag="new_2831121_2831885" /HighExp="S3, BT, S4, LoTm, S7, S8, T5.0H, T4.0H, M9-stat, T3.30H" /AntisenseName="yrbG" /AntisenseCor="0.65629957843767395" /AntisenseRegPval="-33.799999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1049" CDS complement(2327896..2328552) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390646.1" /db_xref="EnsemblGenomes-Gn:BSU27680" /db_xref="EnsemblGenomes-Tr:CAB14728" /db_xref="GOA:O32050" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG13786" /db_xref="UniProtKB/Swiss-Prot:O32050" /translation="MEELLTIAFRTVVLYFVILVIFRFMGKREIGELSILDLVVFIMM AEIAVLAIENVDDHLFHTILPMLVLMIIQVTLAYFSLKNRKVRQLLDGKPTIIIKYGK IDEEAMKSQRYNFDDLMVQLRENSIDRVADVSFAILEPSGKLTIVKKENSGEHRQLEM PLIIDGFIQTENLSRISKDRKWLLESLQKHGYTNPSDISFCSFTDGEIYIDEKDGHRT *" /label="yrbG CDS" gene complement(2327896..2328552) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /label="yrbG gene" promotor_-10 complement(2328571..2328582) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2328583) /Source="Nicolas_upshifts" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2328596..2328602) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2328635..2328640 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2328656..2328674 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2328659 /Source="Nicolas_upshifts" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2328687..2329139 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390647.1" /db_xref="EnsemblGenomes-Gn:BSU27690" /db_xref="EnsemblGenomes-Tr:CAB14729" /db_xref="GOA:O32051" /db_xref="InterPro:IPR023804" /db_xref="SubtiList:BG13815" /db_xref="UniProtKB/Swiss-Prot:O32051" /translation="MSDGFEQKEQKPFNTGREETIMEETKQVGKGILYGLIAIFSAML LTSLAVSLLLTATSLEESSFNWLITAISFLSLFIGGFISGGKGKERGWMIGALTALSF SLIILLFQYLGFGKTFTAEQLIFHLGFLGVCMLGGIFGVNMRGNRSST*" /label="yrzE CDS" gene 2328687..2329139 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /label="yrzE gene" downshifts 2329123 /Source="Nicolas_upshifts" /id="D1418" /incds=0 /nref=39 /ntot=61 /MaxReadThrough="1.45569" /MaxDrop="7.7199" /score="41.7975947" /energy="-15" /TU="NA" /idTUdmin="U2140" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2329178) /Source="Nicolas_upshifts" /id="D1419" /incds=0 /nref=188 /ntot=281 /MaxReadThrough="2.20451" /MaxDrop="7.91954" /score="33.5938356" /energy="-15" /TU="NA" /idTUdmin="U2141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2329196..2329462) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10974125, 16166550, 21235483, 26790414; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the preprotein translocase" /protein_id="NP_390648.2" /db_xref="EnsemblGenomes-Gn:BSU27700" /db_xref="EnsemblGenomes-Tr:CAB14730" /db_xref="GOA:O32052" /db_xref="InterPro:IPR003849" /db_xref="SubtiList:BG13785" /db_xref="UniProtKB/Swiss-Prot:O32052" /translation="MTGTLGTLVPIILMFAVLYFLLIRPQQKQQKAVRQMQEELKKGD SVVTIGGLHGTVDSIDESKVVIKTGDNTRLTFDRRAIREVSAAE*" /label="yrbF CDS" gene complement(2329196..2329462) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /label="yrbF gene" CDS complement(2329499..2330644) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /EC_number="2.4.2.29" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12123838, 14660578, 16199558, 16206323; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-guanine transglycosylase" /protein_id="NP_390649.1" /db_xref="EnsemblGenomes-Gn:BSU27710" /db_xref="EnsemblGenomes-Tr:CAB14731" /db_xref="GOA:O32053" /db_xref="InterPro:IPR002616" /db_xref="InterPro:IPR004803" /db_xref="InterPro:IPR036511" /db_xref="SubtiList:BG12686" /db_xref="UniProtKB/Swiss-Prot:O32053" /translation="MAEQPIRYEFIKECKQTGARLGKVHTPHGSFETPVFMPVGTLAT VKTMSPEELKAMDAGIILSNTYHLWLRPGQDIVKEAGGLHKFMNWDRAILTDSGGFQV FSLSKFRNIEEEGVHFRNHLNGDKLFLSPEKAMEIQNALGSDIMMAFDECPPYPAEYD YMKRSVERTSRWAERCLNAHNRQDEQGLFGIVQGGEYEDLRTQSAKDLISLDFPGYAI GGLSVGEPKDVMNRVLEFTTPLLPKDKPRYLMGVGSPDALIDGAIRGVDMFDCVLPTR IARNGTVFTAEGRLNMKNAKFERDFRPIDEECDCYTCKNYTRAYIRHLIRCNETFGLR LTTYHNLHFLLHLMEQVRQAIREDRLGDFREEFFERYGYNKPNAKSF*" /label="tgt CDS" gene complement(2329499..2330644) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /label="tgt gene" upshifts complement(2329551) /Source="Nicolas_upshifts" /id="U2141" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.432567432567433" /psig="0.164835164835165" /xcortree=2327 /SigmaFactorBS="tacacttaatggagcaggtaagacaggctattcgcgaggatc gtctgggtgatttcaGagaagagttctttgagcgttacggctataacaagccaaatgc g" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2329595) /Source="Nicolas_upshifts" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2329597..2329616) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2329631..2329636) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2330671..2331699) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /EC_number="2.4.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15822125, 17083917, 10739928" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15822125, 17083917, 10739928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine tRNA ribosyltransferase-isomerase" /protein_id="NP_390650.1" /db_xref="EnsemblGenomes-Gn:BSU27720" /db_xref="EnsemblGenomes-Tr:CAB14732" /db_xref="GOA:O32054" /db_xref="InterPro:IPR003699" /db_xref="InterPro:IPR036100" /db_xref="PDB:1YY3" /db_xref="SubtiList:BG12662" /db_xref="UniProtKB/Swiss-Prot:O32054" /translation="MKVDLFDFELPERLIAQVPLEQRDASRLMVLDKHTGELTDSSFK HIISFFNEGDCLVLNNTRVLPARLFGTKEDTGAKVELLLLKQETGDKWETLAKPAKRV KKGTVVTFGDGRLKAICTEELEHGGRKMEFQYDGIFYEVLESLGEMPLPPYIKEQLDD KERYQTVYSKEIGSAAAPTAGLHFTEEILQQLKDKGVQIEFITLHVGLGTFRPVSADE VEEHNMHAEFYQMSEETAAALNKVRENGGRIISVGTTSTRTLETIAGEHDGQFKASSG WTSIFIYPGYEFKAIDGMITNFHLPKSSLIMLVSALAGRENILRAYNHAVEEEYRFFS FGDAMLII*" /label="queA CDS" gene complement(2330671..2331699) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /label="queA gene" CDS complement(2331729..2331929) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="YP_003097768.1" /db_xref="EnsemblGenomes-Gn:BSU27729" /db_xref="EnsemblGenomes-Tr:CAX52674" /db_xref="GOA:C0H463" /db_xref="InterPro:IPR021320" /db_xref="UniProtKB/Swiss-Prot:C0H463" /translation="MTEFPKIIMILGAVLLIIGAVLHFVGKMPGDIFVKKGNVTFFFP VVTCIIISVVLSILLNLFGRMK*" /label="yrzS CDS" gene complement(2331729..2331929) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /label="yrzS gene" CDS complement(2331922..2332926) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /EC_number="3.1.22.4" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14701911, 15317759, 16267290, 19422832, 21600217, 24770420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase, ATP-dependent component" /protein_id="YP_054590.1" /db_xref="EnsemblGenomes-Gn:BSU27730" /db_xref="EnsemblGenomes-Tr:CAB14733" /db_xref="GOA:O32055" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004605" /db_xref="InterPro:IPR008823" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12669" /db_xref="UniProtKB/Swiss-Prot:O32055" /translation="MDERLVSSEADNHESVIEQSLRPQNLAQYIGQHKVKENLRVFID AAKMRQETLDHVLLYGPPGLGKTTLASIVANEMGVELRTTSGPAIERPGDLAAILTAL EPGDVLFIDEIHRLHRSIEEVLYPAMEDFCLDIVIGKGPSARSVRLDLPPFTLVGATT RVGLLTAPLRDRFGVMSRLEYYTQEELADIVTRTADVFEVEIDKPSALEIARRSRGTP RVANRLLRRVRDFAQVLGDSRITEDISQNALERLQVDRLGLDHIDHKLLMGMIEKFNG GPVGLDTISATIGEESHTIEDVYEPYLLQIGFIQRTPRGRIVTPAVYHHFQMEAPRYD *" /label="ruvB CDS" gene complement(2331922..2332926) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /label="ruvB gene" CDS complement(2332937..2333542) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /EC_number="3.1.22.4" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16267290, 24770420" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16267290, 24770420; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase" /protein_id="NP_390652.1" /db_xref="EnsemblGenomes-Gn:BSU27740" /db_xref="EnsemblGenomes-Tr:CAB14734" /db_xref="GOA:O05392" /db_xref="InterPro:IPR000085" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR011114" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013849" /db_xref="InterPro:IPR036267" /db_xref="SubtiList:BG11973" /db_xref="UniProtKB/Swiss-Prot:O05392" /translation="MIEFVKGTIDYVSPQYIVIENGGIGYQIFTPNPFIYKERSQETI FTYHHIREDAFSLYGFSTREEKALFTKLLNVTGIGPKGALAILGSGDPGAVIQAIENE DEAFLVKFPGVGKKTARQIILDLKGKLADVVPEMIENLFNHEERLEKQTAETALEEAL EALRVLGYAEKEIKKVLPHLKEEIGLTTDQYVKKALQKLLK*" /label="ruvA CDS" gene complement(2332937..2333542) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /label="ruvA gene" promotor_-10 complement(2333561..2333580) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2333577) /Source="Nicolas_upshifts" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2333579..2333680) /Source="Nicolas_S_feature" /locus_tag="new_2836807_2836908_c" /HighExp="Etha, Heat, S8, S7, S4, S3, S6, S5, Salt, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1050" promotor_-35 complement(2333591..2333597) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2333681..2334193) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10931291, 16049010" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10931291, 16049010; Product type f: factor" /codon_start=1 /transl_table=11 /product="bypass of forespore C, intercompartmental signaling factor" /protein_id="NP_390653.1" /db_xref="EnsemblGenomes-Gn:BSU27750" /db_xref="EnsemblGenomes-Tr:CAB14735" /db_xref="GOA:O05391" /db_xref="InterPro:IPR015050" /db_xref="InterPro:IPR015071" /db_xref="PDB:2BW2" /db_xref="SubtiList:BG11917" /db_xref="UniProtKB/Swiss-Prot:O05391" /translation="MKRFSTAYLLLGILCSAAVFLIGAPSRALGAEVEHYEPLQVHVQ LEKVYLDGDVSIEHKHEKVFSMDDFWAAYAGWTLVEQKKGYVLFRKQMDDISPLSKVN GYIGVSDNGVISTFHGRPEPASEPIQSFFQIDLERLESHMQKNLLKGIPFRTKAEFED VIEHMKTYSG*" /label="bofC CDS" gene complement(2333681..2334193) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /label="bofC gene" promotor_-10 complement(2334222..2334233) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-10" upshifts complement(2334237) /Source="Nicolas_upshifts" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="upshifts" CDS complement(2334241..2335548) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099855, 14638426, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative catecholate siderophose exporter" /protein_id="NP_390654.2" /db_xref="EnsemblGenomes-Gn:BSU27760" /db_xref="EnsemblGenomes-Tr:CAB14736" /db_xref="GOA:O05390" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11922" /db_xref="UniProtKB/Swiss-Prot:O05390" /translation="MNTVHAKGNVLNKIGIPSHMVWGYIGVVIFMVGDGLEQGWLSPF LVDHGLSMQQSASLFTMYGIAVTISAWLSGTFVQTWGPRKTMTVGLLAFILGSAAFIG WAIPHMYYPALLGSYALRGLGYPLFAYSFLVWVSYSTSQNILGKAVGWFWFMFTCGLN VLGPFYSSYAVPAFGEINTLWSALLFVAAGGILALFFNKDKFTPIQKQDQPKWKELSK AFTIMFENPKVGIGGVVKTINAIGQFGFAIFLPTYLARYGYSVSEWLQIWGTLFFVNI VFNIIFGAVGDKLGWRNTVMWFGGVGCGIFTLALYYTPQLIGHQYWVLMIIACCYGAA LAGYVPLSALLPTLAPDNKGAAMSVLNLGSGLCAFIAPGIVSLFIGPLGAGGVIWIFA ALYFFSAFLTRFLTISEQSTDVYTEERFVRENVQTNFDKTVKQ*" /label="csbX CDS" gene complement(2334241..2335548) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /label="csbX gene" promotor_-35 complement(2334248..2334254) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-35" downshifts complement(2335502) /Source="Nicolas_upshifts" /id="D1420" /incds=0 /nref=2 /ntot=80 /MaxReadThrough="7.18585" /MaxDrop="3.0235" /score="-6.29978124" /energy="-14.3" /TU="U2145,U2146" /idTUdmin="U2146" /TUdmin="-1793" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2335572..2335590) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-10" upshifts complement(2335587) /Source="Nicolas_upshifts" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="upshifts" promotor_-35 complement(2335605..2335611) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-35" CDS complement(2335619..2336644) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative inositol-related oxidoreductase" /protein_id="NP_390655.1" /db_xref="EnsemblGenomes-Gn:BSU27770" /db_xref="EnsemblGenomes-Tr:CAB14737" /db_xref="GOA:O05389" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR030827" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12280" /db_xref="UniProtKB/Swiss-Prot:O05389" /translation="MTKQIVTGIIGAGRIGKLHVQNISRIPHMKIKAISDIQASRIKS WADSHQIEYITSDYRDLLHDPDIDAIFICSPTAVHAQMIKEAAEAKKHIFCEKPVSFS LDETSEALAAVRKHGVTLQVGFNRRFDPHFKKIKTIVENGEIGTPHLLKITSRDPEPP NIDYVRTSGGLFMDMSIHDFDMARYIMGSEVTEVYAKGAALVNPSFAELGDIDTAVIT LTFENGAMAVIDNSRQAVYGYDQRVEVFGTKGSAAADNSRPTTVEVSTADFVMKDKPH FFFLERYKDSYEEEILRFAEAIGTNQETPCTGNDGLQAGRIARAAQQSLAFGMPVSIE HTEKIAF*" /label="yrbE CDS" gene complement(2335619..2336644) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /label="yrbE gene" promotor_-10 complement(2336681..2336700) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-10" upshifts complement(2336701) /Source="Nicolas_upshifts" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="upshifts" promotor_-35 complement(2336715..2336722) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-35" promotor_-35 2336770..2336777 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2336791..2336810 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2336799 /Source="Nicolas_upshifts" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2336831..2336836 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2336845 /Source="Nicolas_upshifts" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2336852..2336870 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2336882..2337529 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /EC_number="2.7.11.1" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative serine/threonine-protein kinase" /protein_id="NP_390656.2" /db_xref="EnsemblGenomes-Gn:BSU27785" /db_xref="EnsemblGenomes-Tr:CAB14738" /db_xref="GOA:O32057" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13816" /db_xref="UniProtKB/Swiss-Prot:O32057" /translation="MLTKAEALAHTVIYRKNSRFDKVKEKSEELTLIGKGRSAYVFAL TEGGRKMALKVFFPEYQATAVKEAAIYEKLAGSAFYPDIYETGDSFILMEYIKGETFY NCLKKGIAISDDMIQQVEEALSDARAAGLNPSDIHLRNLILTETGAVRVIDVARFEQT KTCTQWDDLKSAYHALYKKPIFPKKIPGFWLEIIAFLYKKDWFQKHFAQRKRKYS*" /label="yrzF CDS" gene 2336882..2337529 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /label="yrzF gene" S_feature complement(2337204..2337537) /Source="Nicolas_S_feature" /locus_tag="new_2840432_2840765_c" /HighExp="LPhT, S8, BI, S7, S6, C30, Sw, BC, Gly, C90" /AntisenseName="yrzF" /AntisenseCor="0.348831504804749" /AntisenseRegPval="-8.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1051" downshifts 2337508 /Source="Nicolas_upshifts" /id="D1421" /incds=0 /nref=29 /ntot=228 /MaxReadThrough="2.4121" /MaxDrop="5.05737" /score="20.8102477" /energy="-18.2" /TU="NA" /idTUdmin="U2147" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(2337539..2337736) /Source="Nicolas_S_feature" /locus_tag="new_2840767_2840964_c" /HighExp="LPhT, BI, B60, S8, Gly, S7, S6, B36, S5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984200000000001" /TUshortSig="Sig-" /TUshortPSig="0.032" /TUlongSig="NA" /TUlongPSig="NA" /label="S1052" CDS complement(2337575..2337697) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513992.1" /db_xref="EnsemblGenomes-Gn:BSU27786" /db_xref="EnsemblGenomes-Tr:CCQ48603" /db_xref="UniProtKB/TrEMBL:L8EAY3" /translation="MEKTYCHSGEKDPEAVYLTVRGYRIKLSPEQMKLISAVRK*" /label="hypothetical protein CDS" gene complement(2337575..2337697) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /label="gene" downshifts complement(2337582) /Source="Nicolas_upshifts" /id="D1422" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="4.39913" /MaxDrop="4.52186" /score="39.5790138" /energy="-18.2" /TU="NA" /idTUdmin="U2149" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(2337745) /Source="Nicolas_upshifts" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2337746..2337763) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2337770..2337777) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2337782..2338072 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390658.2" /db_xref="EnsemblGenomes-Gn:BSU27800" /db_xref="EnsemblGenomes-Tr:CAB14740" /db_xref="SubtiList:BG13818" /db_xref="UniProtKB/Swiss-Prot:O32059" /translation="MNPIYSKMREKKGESHIKTENTLSLDAARGELVNEKTLVKRTIY WNYPDSRPAVTWINHNTVKIGNQTLHLDTDETYDWRKDDHWIREEPPQASVR*" /label="yrzH CDS" gene 2337782..2338072 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /label="yrzH gene" misc_feature 2337793..2337812 /Source="Nicolas_upshift_promotors" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2337793..2337940 /Source="Nicolas_S_feature" /locus_tag="new_2841021_2841168" /HighExp="T3.30H, T4.0H, T3.0H, T2.0H, T2.30H, T5.0H, M9-stat, S7, T1.30H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigA" /TUshortPSig="0.903" /TUlongSig="NA" /TUlongPSig="NA" /label="S1053" upshifts 2337793 /Source="Nicolas_upshifts" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="upshifts" CDS 2338079..2338219 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097769.1" /db_xref="EnsemblGenomes-Gn:BSU27809" /db_xref="EnsemblGenomes-Tr:CAX52675" /db_xref="GOA:C0H464" /db_xref="UniProtKB/Swiss-Prot:C0H464" /translation="MNKMNGTNDEKHFNHFVIALSFIYGLTELGYLLLKDFITIAISL PL*" /label="yrzT CDS" gene 2338079..2338219 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /label="yrzT gene" downshifts 2338208 /Source="Nicolas_upshifts" /id="D1423" /incds=0 /nref=139 /ntot=241 /MaxReadThrough="0.64189" /MaxDrop="4.74983" /score="23.2933855" /energy="-9.9" /TU="NA" /idTUdmin="U2150" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2338268..2338274 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2338282..2338382 /Source="Nicolas_upshift_promotors" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2338289..2338307 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2338290 /Source="Nicolas_upshifts" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="upshifts" upshifts 2338342 /Source="Nicolas_upshifts" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="upshifts" CDS 2338383..2339837 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1400476, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium/proton-dependent alanine transporter" /protein_id="NP_390659.2" /db_xref="EnsemblGenomes-Gn:BSU27810" /db_xref="EnsemblGenomes-Tr:CAB14741" /db_xref="GOA:O32060" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG13784" /db_xref="UniProtKB/Swiss-Prot:O32060" /translation="MADFVASLNAVLWSTPVIYILLGIGFAFSIMTRFLQVRHLKEMI VQMFKGKSSEAGVSSFQALSIALSGRVGTGNIAGVATAIAFGGPGAVFWMWAIAFIGA ASAFVESTLAQIYKVKQDGQYRGGPAYYIEKGLGIKWFAVLFAAAALIAMAFLMPGVQ SNSIAAGIQNAFGISPFVTGCGLVLLLGFIIFGGVKRIANAAQMIVPFMAIGYILLSL IIIVMNVSELPAVISLIFKSAFALDSAFGGLIGMAISWGVKRGIYSNEAGQGTGPHPA AAAEVSHPVKQGLVQAFSVYIDTLFVCSATAFMILFTGMYNTQAADGSFIVHQLKGVE AGPGFTQAAIDSVLPGFGAGFVAIALFFFAFTTIMAYYYIAETNIAYLARGRESKWAM LGLKLIILAATFYGTVKTASLAWALGDAGLGIMVWLNVIAIVLLAKPALLALKDYERQ KKQGLDPIFDPKALGIKNADFWEKEYTHESERVS*" /label="alaP CDS" gene 2338383..2339837 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /label="alaP gene" downshifts 2339838 /Source="Nicolas_upshifts" /id="D1424" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="5.01314" /MaxDrop="4.4617" /score="6.86850608" /energy="-10.8" /TU="U2151" /idTUdmin="U2152" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2339878..2340600) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12060744, 18641136, 20647113; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor regulating gene expression" /protein_id="NP_390660.1" /db_xref="EnsemblGenomes-Gn:BSU27820" /db_xref="EnsemblGenomes-Tr:CAB14742" /db_xref="GOA:P94447" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG13783" /db_xref="UniProtKB/Swiss-Prot:P94447" /translation="MAGHSKWKNIQKRKNAQDAKRGKIFMKLAKEIYVAAKEGGADPE ANSALRLVIEKAKGANMPNENIDRAIKKAAGGQDGSSYEEITYEGYGPSGIAVMVECV TDNKNRTASNVRTAFNKNGGSLGESGCVAFLFERKGFITIDRTERQIEEDELMLDVLE AGGEELRIEEDLYEVFTEPEHFEEVKTALESKYLISSAEVTMLPNTYAEADDQAVEKL ETLIDVLEDDDDVQEVYTNYRS*" /label="yrbC CDS" gene complement(2339878..2340600) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /label="yrbC gene" S_feature 2339883..2340304 /Source="Nicolas_S_feature" /locus_tag="new_2843111_2843532" /HighExp="S8, S6, S7, BT, C30, S5, S4, LoTm, C90, S3" /AntisenseName="yrbC" /AntisenseCor="-8.4330852334841305E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1054" downshifts complement(2339894) /Source="Nicolas_upshifts" /id="D1425" /incds=0 /nref=11 /ntot=164 /MaxReadThrough="3.2014" /MaxDrop="3.66865" /score="23.9031001" /energy="-16" /TU="U2153" /idTUdmin="U2153" /TUdmin="-574" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2340623..2340642) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2340640) /Source="Nicolas_upshifts" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2340656..2340663) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2340703..2341299) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9770294, 10438771, 12562816, 17322312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9770294, 10438771, 12562816, 17322312; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_390661.2" /db_xref="EnsemblGenomes-Gn:BSU27830" /db_xref="EnsemblGenomes-Tr:CAB14743" /db_xref="GOA:P94446" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13782" /db_xref="UniProtKB/Swiss-Prot:P94446" /translation="MGKKMTIASLILMTAGLTACGANDNAMNDTRNNGNTRPIGYYTN ENDADRQGDGIDHDGPVSELMEDQNDGNRNTTNVNNRDRVTADDRVPLATDGTYNNTN NRNMNRNAANNGYDNQENRRLAAKIANRVKQVKNVNDTQVMVSDDRVVIAVKSHREFT KSDRDNVVKAARNYANGRDVQVSTDKGLFRKLHKMNNR*" /label="sgpA CDS" gene complement(2340703..2341299) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /label="sgpA gene" downshifts complement(2340718) /Source="Nicolas_upshifts" /id="D1426" /incds=0 /nref=96 /ntot=172 /MaxReadThrough="2.47709" /MaxDrop="7.18444" /score="23.9031001" /energy="-16" /TU="NA" /idTUdmin="U2154" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2341342..2341353) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2341344) /Source="Nicolas_upshifts" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2341346..2341410) /Source="Nicolas_S_feature" /locus_tag="new_2844574_2844638_c" /HighExp="B36, LoTm, S8, S6, S5, BT, B60, S4, S7, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1055" promotor_-35 complement(2341368..2341374) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2341447..2342610) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10438771, 10714986, 10714992, 11040425, 15901704, 26953338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438771, 10714986, 10714992, 11040425, 15901704, 26953338; Product type f : factor" /codon_start=1 /transl_table=11 /product="morphogenetic protein associated with SpoVID" /protein_id="NP_390662.1" /db_xref="EnsemblGenomes-Gn:BSU27840" /db_xref="EnsemblGenomes-Tr:CAB14744" /db_xref="GOA:O32062" /db_xref="InterPro:IPR014248" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13781" /db_xref="UniProtKB/Swiss-Prot:O32062" /translation="MKIHIVQKGDSLWKIAEKYGVDVEEVKKLNTQLSNPDLIMPGMK IKVPSEGVPVRKEPKAGKSPAAGSVKQEHPYAKEKPKSVVDVEDTKPKEKKSMPYVPP MPNLQENVYPEADVNDYYDMKQLFQPWSPPKPEEPKKHHDGNMDHMYHMQDQFPQQEA MSNMENANYPNMPNMPKAPEVGGIEEENVHHTVPNMPMPAVQPYYHYPAHFVPCPVPV SPILPGSGLCYPYYPAQAYPMHPMHGYQPGFVSPQYDPGYENQHHENSHHGHYGSYGA PQYASPAYGSPYGHMPYGPYYGTPQVMGAYQPAAAHGYMPYKDHDDCGCDGDHQPYFS APGHSGMGAYGSPNMPYGTANPNPNPYSAGVSMPMTNQPSVNQMFGRPEEENE*" /label="safA CDS" gene complement(2341447..2342610) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /label="safA gene" downshifts complement(2341455) /Source="Nicolas_upshifts" /id="D1427" /incds=0 /nref=34 /ntot=189 /MaxReadThrough="5.61903" /MaxDrop="3.9565" /score="38.1347732" /energy="-11.1" /TU="U2155,U2156,U2159" /idTUdmin="U2154" /TUdmin="-749" /isTUend="FALSE" /label="downshifts" S_feature complement(2342611..2342686) /Source="Nicolas_S_feature" /locus_tag="new_2845839_2845914_c" /HighExp="S5, S4, B36, LoTm, S3, B60, S7, S6, Pyr, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1056" promotor_-10 complement(2342662..2342680) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2342686) /Source="Nicolas_upshifts" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2342696..2342701) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2342727..2343833) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /EC_number="2.5.1.72" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15898769, 15937336, 15967443, 18959769, 26455817" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15898769, 15937336, 15967443, 18959769, 26455817; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quinolinate synthetase" /protein_id="NP_390663.1" /db_xref="EnsemblGenomes-Gn:BSU27850" /db_xref="EnsemblGenomes-Tr:CAB14745" /db_xref="GOA:Q9KWZ1" /db_xref="InterPro:IPR003473" /db_xref="InterPro:IPR023515" /db_xref="InterPro:IPR036094" /db_xref="SubtiList:BG12629" /db_xref="UniProtKB/Swiss-Prot:Q9KWZ1" /translation="MSILDVIKQSNDMMPESYKELSRKDMETRVAAIKKKFGSRLFIP GHHYQKDEVIQFADQTGDSLQLAQVAEKNKEADYIVFCGVHFMAETADMLTSEQQTVV LPDMRAGCSMADMADMQQTNRAWKKLQHIFGDTIIPLTYVNSTAEIKAFVGKHGGATV TSSNAKKVLEWAFTQKKRILFLPDQHLGRNTAYDLGIALEDMAVWDPMKDELVAESGH TNVKVILWKGHCSVHEKFTTKNIHDMRERDPDIQIIVHPECSHEVVTLSDDNGSTKYI IDTINQAPAGSKWAIGTEMNLVQRIIHEHPDKQIESLNPDMCPCLTMNRIDLPHLLWS LEQIEKGEPSGVIKVPKAIQEDALLALNRMLSIT*" /label="nadA CDS" gene complement(2342727..2343833) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /label="nadA gene" promotor_-10 complement(2343409..2343427) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2343434) /Source="Nicolas_upshifts" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2343443..2343448) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2343745 /Source="Nicolas_upshifts" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2343746..2343749 /Source="Nicolas_upshift_promotors" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2343820..2344689) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /EC_number="2.4.2.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8419294, 28618168; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)" /protein_id="NP_390664.1" /db_xref="EnsemblGenomes-Gn:BSU27860" /db_xref="EnsemblGenomes-Tr:CAB14746" /db_xref="GOA:P39666" /db_xref="InterPro:IPR002638" /db_xref="InterPro:IPR004393" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022412" /db_xref="InterPro:IPR027277" /db_xref="InterPro:IPR036068" /db_xref="InterPro:IPR037128" /db_xref="SubtiList:BG10868" /db_xref="UniProtKB/Swiss-Prot:P39666" /translation="MNHLQLKKLLNHFFLEDIGTGDLTSQSIFGEQSCEAEIVAKSEG IFAGAAIIKEGFSLLDENVQSILHKKDGDMLHKGEVIAELHGPAAALLSGERVVLNLI QRLSGIATMTREAVRCLDDEQIKICDTRKTTPGLRMLEKYAVRAGGGYNHRFGLYDGI MIKDNHIAACGSILEACKKARQAAGHMVNIEVEIETEEQLREAIAAGADVIMFDNCPP DTVRHFAKLTPANIKTEASGGITLESLPAFKGTGVNYISLGFLTHSVKSLDISMDVTL SNESVEECCYVNS*" /label="nadC CDS" gene complement(2343820..2344689) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /label="nadC gene" downshifts 2343914 /Source="Nicolas_upshifts" /id="D1428" /incds=1 /nref=4 /ntot=107 /MaxReadThrough="0.495279999999999" /MaxDrop="3.83418" /score="-8.75482157" /energy="-7.4" /TU="NA" /idTUdmin="U2157" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(2344643..2346238) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /EC_number="1.4.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 16199587, 18959769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 16199587, 18959769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-aspartate oxidase" /protein_id="NP_390665.1" /db_xref="EnsemblGenomes-Gn:BSU27870" /db_xref="EnsemblGenomes-Tr:CAB14747" /db_xref="GOA:P38032" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR005288" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10867" /db_xref="UniProtKB/Swiss-Prot:P38032" /translation="MSKKTIAVIGSGAAALSLAAAFPPSYEVTVITKKSVKNSNSVYA QGGIAAAYAKDDSIEAHLEDTLYAGCGHNNLAIVADVLHDGKMMVQSLLERGFPFDRN ERGGVCLGREGAHSYNRIFHAGGDATGRLLIDYLLKRINSKIKLIENETAADLLIEDG RCIGVMTKDSKGRLKVRHADEVVLAAGGCGNLFLHHTNDLTVTGDGLSLAYRAGAELT DLEFTQFHPTLLVKNGVSYGLVSEAVRGEGGCLVDENGRRIMAERHPLGDLAPRDIVS RVIHEEMAKGNRVYIDFSAISDFETRFPTITAICEKAGIDIHSGKIPVAPGMHFLMGG VSVNRWGETTVPGLYAIGETACSGLHGANRLASNSLLEALVFGKRAAEHIIQKPVYNR QYQSGLETSVFYEVPDIEGHELQSKMTSHMSILREQSSLIELSIWLHTLPFQEVNVKD ITIRQMELSHLWQTAKLMTFSALLREESRGAHFRTDFPHAEVSWQGRQIVHTKKGTKI RKNEGIWNNESFTAEKITESLFS*" /label="nadB CDS" gene complement(2344643..2346238) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /label="nadB gene" promotor_-35 2346266..2346273 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2346266..2346285) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2346287 /Source="Nicolas_upshifts" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2346289..2346308 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2346290) /Source="Nicolas_upshifts" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2346300..2346307) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2346341..2347528 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 14567704, 16199587, 25447671, 26443755, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 14567704, 16199587, 25447671, 26443755, 28882201; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="desulfurase involved in iron-sulfur clusters forNAD biosynthesis" /protein_id="NP_390666.1" /db_xref="EnsemblGenomes-Gn:BSU27880" /db_xref="EnsemblGenomes-Tr:CAB14748" /db_xref="GOA:P38033" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG10866" /db_xref="UniProtKB/Swiss-Prot:P38033" /translation="MIYLDYAATTPICEEALTVYQKLSMDMYGNASSLHDAGGKAKHI LEYCREKIANIIGGEASGIYFTSGGTESNFLAIQSLLNGLPKTKRHFITTAMEHQSIH NCAAFLEQQGYDVTVIEPNEYGLITEEILLTHIRPETGLVSIQHANSETGIIQPIQHL SSYLHNKGILLHCDAVQTFGKIPINTKNLGVDALSMSSHKIHGPKGVGAVYIRPDVPW KPVYPLTTHEYGFRAGTVNVPGIGAFTAAAELIVSEMEKQISRNEALRTYFLDQIRIR SLPVTLAADTSKAECLPHIIGCFFHSFEGQYVMLECNRSNICISTGSACSAGYHGPSE TMKALRKTEQEALQFIRISFGRHTTAEQLEQLLHTFTVLWEQKKGEFDIDRRIKANGR QQA*" /label="nifS CDS" gene 2346341..2347528 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /label="nifS gene" promotor_-10 complement(2346342..2346361) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2346360) /Source="Nicolas_upshifts" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2346376..2346385) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2347243..2347248 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2347257 /Source="Nicolas_upshifts" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2347259..2347278 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2347488..2348030 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16199587, 18276644" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16199587, 18276644; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of de novo NAD biosynthesis" /protein_id="NP_390667.2" /db_xref="EnsemblGenomes-Gn:BSU27890" /db_xref="EnsemblGenomes-Tr:CAB14749" /db_xref="GOA:P39667" /db_xref="InterPro:IPR004173" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026043" /db_xref="InterPro:IPR035922" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10865" /db_xref="UniProtKB/Swiss-Prot:P39667" /translation="MTEELKLMGANRRDQLLLWLKESKSPLTGGELAKKANVSRQVIV QDISLLKAKNVPIIATSQGYVYMDAAAQQHQQAERIIACLHGPERTEEELQLIVDEGV TVKDVKIEHPVYGDLTAAIQVGTRKEVSHFIKKINSTNAAYLSQLTDGVHLHTLTAPD EHRIDQACQALEEAGILIKD*" /label="niaR CDS" gene 2347488..2348030 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /label="niaR gene" downshifts 2348013 /Source="Nicolas_upshifts" /id="D1429" /incds=0 /nref=109 /ntot=246 /MaxReadThrough="3.55509" /MaxDrop="5.04771" /score="15.054047" /energy="-5.6" /TU="U2158" /idTUdmin="U2161" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2348055..2348912) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /EC_number="4.2.1.51" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:104661, 114523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104661, 114523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydratase" /protein_id="NP_390668.1" /db_xref="EnsemblGenomes-Gn:BSU27900" /db_xref="EnsemblGenomes-Tr:CAB14750" /db_xref="GOA:P21203" /db_xref="InterPro:IPR001086" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008242" /db_xref="InterPro:IPR018528" /db_xref="SubtiList:BG10914" /db_xref="UniProtKB/Swiss-Prot:P21203" /translation="MKVGYLGPAATFTHLAVSSCFQNGAEHVAYRTIPECIDAAVAGE VDFAFVPLENALEGSVNLTIDYLIHEQPLPIVGEMTLPIHQHLLVHPSRENAWKELDK IYSHSHAIAQCHKFLHRHFPSVPYEYANSTGAAAKFVSDHPELNIGVIANDMAASTYE LKIVKRDIQDYRDNHTRFVILSPDENISFEVNSKLSSRPKTTLMVMLPQDDQSGALHR VLSAFSWRNLNLSKIESRPTKTGLGHYFFIIDIEKAFDDVLIPGAMQELEALGCKVRL LGAYQSYQL*" /label="pheA CDS" gene complement(2348055..2348912) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /label="pheA gene" S_feature 2348058..2348767 /Source="Nicolas_S_feature" /locus_tag="new_2851286_2851995" /HighExp="S2, T-5.40H, T3.30H, T-4.40H, GM-0.2, GM-0.1, Pyr, T4.0H, T5.0H, GM 10" /AntisenseName="pheA" /AntisenseCor="-0.15664933741609299" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1057" downshifts complement(2348075) /Source="Nicolas_upshifts" /id="D1430" /incds=0 /nref=173 /ntot=247 /MaxReadThrough="1.87872" /MaxDrop="5.15605" /score="13.965695" /energy="-5.6" /TU="NA" /idTUdmin="U2162" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2348929..2349372) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /experiment="publication(s) with functional evidences, PMID:2537815, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2537815, 27260660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of operons hom-thrCB and thrD" /protein_id="NP_390669.1" /db_xref="EnsemblGenomes-Gn:BSU27910" /db_xref="EnsemblGenomes-Tr:CAB14751" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008310" /db_xref="SubtiList:BG10913" /db_xref="UniProtKB/Swiss-Prot:P21204" /translation="MKEETFYLVREDVLPDAMRKTLEVKKLLDRKKADSVADAVQKVD LSRSAFYKYRDAVFPFYTMVKEQIITLFFHLEDRSGALSQLLQAVADSGSNVLSIHQT IPLQGRANVTLSISTSAMEEDIHTLMNKLRKFDFVEKVEILGSGA*" /label="thrR CDS" gene complement(2348929..2349372) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /label="thrR gene" CDS complement(2349433..2350719) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ppGpp-binding GTPase involved in cell portioning, DNA repair and ribosome assembly" /protein_id="NP_390670.1" /db_xref="EnsemblGenomes-Gn:BSU27920" /db_xref="EnsemblGenomes-Tr:CAB14752" /db_xref="GOA:P20964" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR006074" /db_xref="InterPro:IPR006169" /db_xref="InterPro:IPR014100" /db_xref="InterPro:IPR015349" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="InterPro:IPR035101" /db_xref="InterPro:IPR036346" /db_xref="InterPro:IPR036726" /db_xref="PDB:1LNZ" /db_xref="SubtiList:BG10337" /db_xref="UniProtKB/Swiss-Prot:P20964" /translation="MFVDQVKVYVKGGDGGNGMVAFRREKYVPKGGPAGGDGGKGGDV VFEVDEGLRTLMDFRYKKHFKAIRGEHGMSKNQHGRNADDMVIKVPPGTVVTDDDTKQ VIADLTEHGQRAVIARGGRGGRGNSRFATPANPAPQLSENGEPGKERYIVLELKVLAD VGLVGFPSVGKSTLLSVVSSAKPKIADYHFTTLVPNLGMVETDDGRSFVMADLPGLIE GAHQGVGLGHQFLRHIERTRVIVHVIDMSGLEGRDPYDDYLTINQELSEYNLRLTERP QIIVANKMDMPEAAENLEAFKEKLTDDYPVFPISAVTREGLRELLFEVANQLENTPEF PLYDEEELTQNRVMYTMENEEVPFNITRDPDGVFVLSGDSLERLFKMTDFSRDESVKR FARQMRGMGVDEALRERGAKDGDIIRLLEFEFEFID*" /label="obgE CDS" gene complement(2349433..2350719) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /label="obgE gene" CDS complement(2350753..2351331) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation initiation phosphotransferase" /protein_id="NP_390671.1" /db_xref="EnsemblGenomes-Gn:BSU27930" /db_xref="EnsemblGenomes-Tr:CAB14753" /db_xref="GOA:P06535" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR016122" /db_xref="InterPro:IPR037100" /db_xref="PDB:1F51" /db_xref="PDB:1IXM" /db_xref="PDB:2FTK" /db_xref="SubtiList:BG10336" /db_xref="UniProtKB/Swiss-Prot:P06535" /translation="MKDVSKNQEENISDTALTNELIHLLGHSRHDWMNKLQLIKGNLS LQKYDRVFEMIEEMVIDAKHESKLSNLKTPHLAFDFLTFNWKTHYMTLEYEVLGEIKD LSAYDQKLAKLMRKLFHLFDQAVSRESENHLTVSLQTDHPDRQLILYLDFHGAFADPS AFDDIRQNGYEDVDIMRFEITSHECLIEIGLD*" /label="spo0B CDS" gene complement(2350753..2351331) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /label="spo0B gene" S_feature complement(2351332..2351397) /Source="Nicolas_S_feature" /locus_tag="new_2854560_2854625_c" /HighExp="Cold, H2O2, G135, Paraq, G180, Oxctl, G150, C30, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigEF" /TUlongPSig=1 /label="S1058" promotor_-10 complement(2351382..2351401) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2351397) /Source="Nicolas_upshifts" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2351399..2351616) /Source="Nicolas_S_feature" /locus_tag="new_2854627_2854844_c" /HighExp="Cold, G135, H2O2, Paraq, G180, Oxctl, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1059" CDS 2351409..2351531 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513993.1" /translation="MLEKQLFFPEISCSFFLALVDLQPGRTFYVLLLGEHIQWV*" /label="hypothetical protein CDS" gene 2351409..2351531 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /label="gene" promotor_-35 complement(2351415..2351422) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2351652..2351936) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 (BL24)" /protein_id="NP_390672.1" /db_xref="EnsemblGenomes-Gn:BSU27940" /db_xref="EnsemblGenomes-Tr:CAB14754" /db_xref="GOA:P05657" /db_xref="InterPro:IPR001684" /db_xref="InterPro:IPR018261" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10335" /db_xref="UniProtKB/Swiss-Prot:P05657" /translation="MLRLDLQFFASKKGVGSTKNGRDSEAKRLGAKRADGQFVTGGSI LYRQRGTKIYPGENVGRGGDDTLFAKIDGTVKFERFGRDRKKVSVYPVAQ*" /label="rpmA CDS" gene complement(2351652..2351936) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /label="rpmA gene" downshifts complement(2351661) /Source="Nicolas_upshifts" /id="D1431" /incds=0 /nref=212 /ntot=261 /MaxReadThrough="7.39131" /MaxDrop="7.26483" /score="32.4992871" /energy="-12.5" /TU="U2163" /idTUdmin="U2164" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" CDS complement(2351949..2352287) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11567142, 22333191, 25388641, 27435445, 28187498; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 specific N-terminal end cysteine protease" /protein_id="NP_390673.2" /db_xref="EnsemblGenomes-Gn:BSU27950" /db_xref="EnsemblGenomes-Tr:CAB14755" /db_xref="InterPro:IPR007422" /db_xref="InterPro:IPR036764" /db_xref="SubtiList:BG10334" /db_xref="UniProtKB/Swiss-Prot:P26942" /translation="MIQATIRRSHDKGILSFEMTGHANFAEHGQDLVCAGVTAVVFGA VNAVIVLAGFEPLLDIGEDGGYFYFEFPESLDPEARQKAQLLIEGMIVSLETIERDYK DNLRVTTNII*" /label="rppA CDS" gene complement(2351949..2352287) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /label="rppA gene" CDS complement(2352290..2352598) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8223574, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8223574, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L21 (BL20)" /protein_id="NP_390674.1" /db_xref="EnsemblGenomes-Gn:BSU27960" /db_xref="EnsemblGenomes-Tr:CAB14756" /db_xref="GOA:P26908" /db_xref="InterPro:IPR001787" /db_xref="InterPro:IPR018258" /db_xref="InterPro:IPR028909" /db_xref="InterPro:IPR036164" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10333" /db_xref="UniProtKB/Swiss-Prot:P26908" /translation="MYAIIKTGGKQIKVEEGQTVYIEKLAAEAGETVTFEDVLFVGGD NVKVGNPTVEGATVTAKVEKQGRAKKITVFRYKPKKNVHKKQGHRQPYTKVTIEKINA *" /label="rplU CDS" gene complement(2352290..2352598) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /label="rplU gene" misc_RNA complement(2352612..2352687) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /product="ribosomal protein L21 leader mRNA sequence" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27381917" /label="ldlU RNA" gene complement(2352612..2352687) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /label="ldlU gene" promotor_-10 complement(2352699..2352718) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2352719) /Source="Nicolas_upshifts" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2352732..2352739) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2352745..2353611) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /EC_number="3.4.24.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease [proteolysis of pro-sigma(K)]" /protein_id="NP_390675.1" /db_xref="EnsemblGenomes-Gn:BSU27970" /db_xref="EnsemblGenomes-Tr:CAB14757" /db_xref="GOA:P26937" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG10332" /db_xref="UniProtKB/Swiss-Prot:P26937" /translation="MNKWLDLILKIHVHPFLWIIAALGLLTGHMKALLCLLLIVLIHE LGHAALAVFFSWRIKRVFLLPFGGTVEVEEHGNRPLKEEFAVIIAGPLQHIWLQFAAW MLAEVSVIHQHTFELFTFYNLSILFVNLLPIWPLDGGKLLFLLFSKQLPFQKAHRLNL KTSLCFCLLLGCWVLFVIPLQISAWVLFVFLAVSLFEEYRQRHYIHVRFLLERYYGKN RELEKLLPLTVKAEDKVYHVMAEFKRGCKHPIIIEKSGQKLSQLDENEVLHAYFADKR TNSSMEELLLPY*" /label="spoIVFB CDS" gene complement(2352745..2353611) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /label="spoIVFB gene" CDS complement(2353604..2354398) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpoIVFB (stage IV sporulation)" /protein_id="NP_390676.1" /db_xref="EnsemblGenomes-Gn:BSU27980" /db_xref="EnsemblGenomes-Tr:CAB14758" /db_xref="GOA:P26936" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG10331" /db_xref="UniProtKB/Swiss-Prot:P26936" /translation="MSHRADEIRKRLEKRRKQLSGSKRFSTQTVSEKQKPPSWVMVTD QEKHGTLPVYEDNMPTFNGKHPLVKTDSIILKCLLSACLVLVSAIAYKTNIGPVSQIK PAVAKTFETEFQFASASHWFETKFGNPLAFLAPEHKNKEQQIEVGKDLIAPASGKVQQ DFQDNGEGIKVETSSDKIDSVKEGYVVEVSKDSQTGLTVKVQHADNTYSIYGELKDVD VALYDFVDKGKKLGSIKLDDHNKGVYYFAMKDGDKFIDPIQVISFE*" /label="spoIVFA CDS" gene complement(2353604..2354398) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /label="spoIVFA gene" downshifts 2354401 /Source="Nicolas_upshifts" /id="D1432" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="1.00279" /MaxDrop="2.6024" /score="-6.66807377" /energy="-6.9" /TU="NA" /idTUdmin="U2165" /TUdmin="-131" /isTUend="FALSE" /label="downshifts" promotor_no_box 2354407..2354507 /Source="Nicolas_upshift_promotors" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(2354422..2354440) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-10" upshifts complement(2354433) /Source="Nicolas_upshifts" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="upshifts" promotor_-35 complement(2354456..2354461) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-35" upshifts 2354467 /Source="Nicolas_upshifts" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2354510 /Source="Nicolas_upshifts" /id="D1433" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="1.68429" /MaxDrop="7.01891" /score="-6.66807377" /energy="-6.9" /TU="U2165" /idTUdmin="U2165" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(2354545) /Source="Nicolas_upshifts" /id="D1434" /incds=0 /nref=236 /ntot=262 /MaxReadThrough="2.68001" /MaxDrop="5.80551" /score="40.3102023" /energy="-12.6" /TU="U2166" /idTUdmin="U2167" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2354548..2355354) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase activator of MinC" /protein_id="NP_390677.1" /db_xref="EnsemblGenomes-Gn:BSU27990" /db_xref="EnsemblGenomes-Tr:CAB14759" /db_xref="GOA:Q01464" /db_xref="InterPro:IPR002586" /db_xref="InterPro:IPR010223" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10330" /db_xref="UniProtKB/Swiss-Prot:Q01464" /translation="MGEAIVITSGKGGVGKTTTSANLGTALAILGKRVCLVDTDIGLR NLDVVMGLENRIIYDLVDVVEGRCKMHQALVKDKRFDDLLYLMPAAQTSDKTAVAPEQ IKNMVQELKQEFDYVIIDCPAGIEQGYKNAVSGADKAIVVTTPEISAVRDADRIIGLL EQEENIEPPRLVVNRIRNHLMKNGDTMDIDEIVQHLSIDLLGIVADDDEVIKASNHGE PIAMDPKNRASIAYRNIARRILGESVPLQVLEEQNKGMMAKIKSFFGVRS*" /label="minD CDS" gene complement(2354548..2355354) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /label="minD gene" CDS complement(2355356..2356036) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division regulator (septum placement)" /protein_id="NP_390678.1" /db_xref="EnsemblGenomes-Gn:BSU28000" /db_xref="EnsemblGenomes-Tr:CAB14760" /db_xref="GOA:Q01463" /db_xref="InterPro:IPR005526" /db_xref="InterPro:IPR013033" /db_xref="InterPro:IPR036145" /db_xref="PDB:2M4I" /db_xref="SubtiList:BG10329" /db_xref="UniProtKB/Swiss-Prot:Q01463" /translation="MKTKKQQYVTIKGTKNGLTLHLDDACSFDELLDGLQNMLSIEQY TDGKGQKISVHVKLGNRFLYKEQEEQLTELIASKKDLFVHSIDSEVITKKEAQQIREE AEIISVSKIVRSGQVLQVKGDLLLIGDVNPGGTVRAGGNIFVLGSLKGIAHAGFNGNN QAVIAASEMLPTQLRINHVLNRSPDHIQKGNEMECAYLDTDGNMVIERLQHLAHLRPD LTRLEGGM*" /label="minC CDS" gene complement(2355356..2356036) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /label="minC gene" CDS complement(2356089..2356607) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 18156271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 18156271; Product type s: structure" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390679.1" /db_xref="EnsemblGenomes-Gn:BSU28010" /db_xref="EnsemblGenomes-Tr:CAB14761" /db_xref="GOA:Q01467" /db_xref="InterPro:IPR007227" /db_xref="SubtiList:BG10328" /db_xref="UniProtKB/Swiss-Prot:Q01467" /translation="MKRFLLPFVMMLVFSAESIFTDLVHFPFVTDDQVLAPRFLMLVL IFMSAFINQKHAMIYGFIFGFLYDMNYTSLLGVYMFGFAGLCYLASKAFKVLHTNAFV VILIAVLAVCLLEFYVFGIQSLIHKDIMTFNGFVLDRFIPTILLNIAAALILVLPFRL FFMSLKKELRDE*" /label="mreD CDS" gene complement(2356089..2356607) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /label="mreD gene" CDS complement(2356604..2357476) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 17427287, 20623345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 17427287, 20623345; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390680.2" /db_xref="EnsemblGenomes-Gn:BSU28020" /db_xref="EnsemblGenomes-Tr:CAB14762" /db_xref="GOA:Q01466" /db_xref="InterPro:IPR007221" /db_xref="SubtiList:BG10327" /db_xref="UniProtKB/Swiss-Prot:Q01466" /translation="MPNKRLMLLLLCIIILVAMIGFSLKGGRNTTWPEKVIGDTTGVF QNIFHTPAEFFAGIFENINDLKNTYKENERLREKLDGQTQYEAKLQELEEENKSLRDE LGHVKSIKDYKPILATVIARSPDNWAKQVTINKGTQQNVAKDMAVTNEKGALIGKIKS SGLNNFTSAVQLLSDTDRNNRVATKISGKKGSKGYGLIEGYDKEKKRLKMTIIERKDK QDVKKGDLIETSGTGGVFPEGLTIGEVTDIESDSYGLTKVAYVKPAADLTDLNNVIVV NRDVPTVDTEEEGS*" /label="mreC CDS" gene complement(2356604..2357476) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /label="mreC gene" CDS complement(2357507..2358520) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390681.2" /db_xref="EnsemblGenomes-Gn:BSU28030" /db_xref="EnsemblGenomes-Tr:CAB14763" /db_xref="GOA:Q01465" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10326" /db_xref="UniProtKB/Swiss-Prot:Q01465" /translation="MFGIGARDLGIDLGTANTLVFVKGKGIVVREPSVVALQTDTKSI VAVGNDAKNMIGRTPGNVVALRPMKDGVIADYETTATMMKYYINQAIKNKGMFARKPY VMVCVPSGITAVEERAVIDATRQAGARDAYPIEEPFAAAIGANLPVWEPTGSMVVDIG GGTTEVAIISLGGIVTSQSIRVAGDEMDDAIINYIRKTYNLMIGDRTAEAIKMEIGSA EAPEESDNMEIRGRDLLTGLPKTIEITGKEISNALRDTVSTIVEAVKSTLEKTPPELA ADIMDRGIVLTGGGALLRNLDKVISEETKMPVLIAEDPLDCVAIGTGKALEHIHLFKG KTR*" /label="mreB CDS" gene complement(2357507..2358520) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /label="mreB gene" upshifts complement(2358561) /Source="Nicolas_upshifts" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2358573..2358591) /Source="Nicolas_upshift_promotors" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2358612..2359307) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10652786, 17434969, 18556794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved nucleotide-related metabolism protein" /protein_id="NP_390682.1" /db_xref="EnsemblGenomes-Gn:BSU28040" /db_xref="EnsemblGenomes-Tr:CAB14764" /db_xref="GOA:Q02170" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR001405" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR020891" /db_xref="InterPro:IPR025657" /db_xref="SubtiList:BG10325" /db_xref="UniProtKB/Swiss-Prot:Q02170" /translation="MVIHDLPLKLKDFPMKEKPRERLLKVGAENLANHELLAILLRTG TKHESVLDLSNRLLRSFDGLRLLKEASVEELSSIPGIGMVKAIQILAAVELGSRIHKL ANEEHFVIRSPEDGANLVMEDMRFLTQEHFVCLYLNTKNQVIHKRTVFIGSLNSSIVH PREVFKEAFKRSAASFICVHNHPSGDPTPSREDIEVTRRLFECGNLIGIELLDHLVIG DKKFVSLKEKGYL*" /label="ysxA CDS" gene complement(2358612..2359307) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /label="ysxA gene" CDS complement(2359344..2359913) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /EC_number="3.6.1.9" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10841541, 16216582, 21564336, 24210219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10841541, 16216582, 21564336, 24210219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside triphosphate pyrophosphatase; septum formation DNA-binding protein (multicopy associated filamentation)" /protein_id="NP_390683.1" /db_xref="EnsemblGenomes-Gn:BSU28050" /db_xref="EnsemblGenomes-Tr:CAB14765" /db_xref="GOA:Q02169" /db_xref="InterPro:IPR003697" /db_xref="InterPro:IPR029001" /db_xref="PDB:1EX2" /db_xref="PDB:1EXC" /db_xref="PDB:4HEB" /db_xref="SubtiList:BG10324" /db_xref="UniProtKB/Swiss-Prot:Q02169" /translation="MTKPLILASQSPRRKELLDLLQLPYSIIVSEVEEKLNRNFSPEE NVQWLAKQKAKAVADLHPHAIVIGADTMVCLDGECLGKPQDQEEAASMLRRLSGRSHS VITAVSIQAENHSETFYDKTEVAFWSLSEEEIWTYIETKEPMDKAGAYGIQGRGALFV KKIDGDYYSVMGLPISKTMRALRHFDIRA*" /label="maf CDS" gene complement(2359344..2359913) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /label="maf gene" promotor_-10 complement(2359765..2359780) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2359774) /Source="Nicolas_upshifts" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2359793..2359802) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2359952..2359971) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2359968) /Source="Nicolas_upshifts" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2359985..2359991) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2360064) /Source="Nicolas_upshifts" /id="D1435" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="1.92542" /MaxDrop="5.77117" /score="8.94061802" /energy="-7.4" /TU="NA" /idTUdmin="U2169" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2360066..2361064) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16959571, 17376078, 22720735, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16959571, 17376078, 22720735, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spatial and temporal regulator of the dissolution of septal peptidoglycan during engulfment (stage II sporulation)" /protein_id="NP_390684.1" /db_xref="EnsemblGenomes-Gn:BSU28060" /db_xref="EnsemblGenomes-Tr:CAB14766" /db_xref="GOA:P37575" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10912" /db_xref="UniProtKB/Swiss-Prot:P37575" /translation="MKKRKNKKNSKAAEKALKVTINGKEETVYEQETPETEANKSMTF SNWEEKRQAEQEVAASQEHPDEDEFNWDSEEDKVFKEDPKVVPPFQKKKTKLYAKGKT GAAKPVKRVAATIAFAAVIGTGLGLFALNISGNKEASAPASLEDSLGSQTAKAGDTSA DKQTSGAEKQAAQTEGTYKTYAVQAGKFSNEKGAETLTEQLTEKGYSAVSLSKDDGYT YVIAGLASEKEVSQQLGQVLIDSDFEAWGGKELSLSIESDMTDSFKETAELAAKAILD EDITKASVEKIEKSLGETKASETGEKKAILQALKELEDPSAEAGWKAQQELLAVVK*" /label="spoIIB CDS" gene complement(2360066..2361064) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /label="spoIIB gene" promotor_-10 complement(2361111..2361130) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2361119) /Source="Nicolas_upshifts" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2361142..2361149) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2361187) /Source="Nicolas_upshifts" /id="D1436" /incds=0 /nref=1 /ntot=56 /MaxReadThrough="3.18314" /MaxDrop="2.89774" /score="11.209969" /energy="-7.6" /TU="U2170" /idTUdmin="U2170" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS complement(2361198..2361944) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /EC_number="3.4.23.43" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2553669, 9723928, 15849754, 16751195, 16850406, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2553669, 9723928, 15849754, 16751195, 16850406, 16751195; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane prepilin peptidase" /protein_id="NP_390685.2" /db_xref="EnsemblGenomes-Gn:BSU28070" /db_xref="EnsemblGenomes-Tr:CAB14767" /db_xref="GOA:P15378" /db_xref="InterPro:IPR000045" /db_xref="InterPro:IPR010627" /db_xref="SubtiList:BG10323" /db_xref="UniProtKB/Swiss-Prot:P15378" /translation="MLSILFIFGLILGSFYYTAGCRIPLHLSIIAPRSSCPFCRRTLT PAELIPILSFLFQKGKCKSCGHRISFMYPAAELVTACLFAAAGIRFGISLELFPAVVF ISLLIIVAVTDIHFMLIPNRILIFFLPFLAAARLISPLDSWYAGLLGAAAGFLFLAVI AAITHGGVGGGDIKLFAVIGFVLGVKMLAAAFFFSVLIGALYGAAAVLTGRLAKRQPL PFAPAIAAGSILAYLYGDSIISFYIKMALG*" /label="comC CDS" gene complement(2361198..2361944) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /label="comC gene" promotor_-10 complement(2361972..2361991) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2361979) /Source="Nicolas_upshifts" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2362006..2362013) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2362084..2363376) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /EC_number="6.3.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2105929, 2985605, 3040739, 6994831, 9098041, 15705579, 22720735, 26443588; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="folyl-polyglutamate synthase" /protein_id="NP_390686.1" /db_xref="EnsemblGenomes-Gn:BSU28080" /db_xref="EnsemblGenomes-Tr:CAB14768" /db_xref="GOA:Q05865" /db_xref="InterPro:IPR001645" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR018109" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10322" /db_xref="UniProtKB/Swiss-Prot:Q05865" /translation="MFTAYQDARSWIHGRLKFGVKPGLGRMKQLMARLGHPEKKIRAF HVAGTNGKGSTVAFIRSMLQEAGYTVGTFTSPYIITFNERISVNGIPISDEEWTALVN QMKPHVEALDQTEYGQPTEFEIMTACAFLYFAEFHKVDFVIFETGLGGRFDSTNVVEP LLTVITSIGHDHMNILGNTIEEIAGEKAGIIKEGIPIVTAVTQPEALQVIRHEAERHA APFQSLHDACVIFNEEALPAGEQFSFKTEEKCYEDIRTSLIGTHQRQNAALSILAAEW LNKENIAHISDEALRSGLVKAAWPGRLELVQEHPPVYLDGAHNEEGVEKLAETMKQRF ANSRISVVFSALKDKPYQNMIKRLETIAHAIHFASFDFPRASLAKDLYDASEISNKSW SEDPDDVIKFIESKKGSNEIVLITGSLYFISDIRKRLK*" /label="folC CDS" gene complement(2362084..2363376) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /label="folC gene" downshifts complement(2362089) /Source="Nicolas_upshifts" /id="D1437" /incds=0 /nref=1 /ntot=121 /MaxReadThrough="1.66565" /MaxDrop="3.18428" /score="24.7086033" /energy="-14.3" /TU="NA" /idTUdmin="U2171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2363377..2363435) /Source="Nicolas_S_feature" /locus_tag="new_2866605_2866663_c" /HighExp="S0, LBGexp, G150, MG 45, G135, G180, Gly, Oxctl, M0t45, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1060" CDS complement(2363436..2366078) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /EC_number="6.1.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9098041, 11114335, 25310979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 11114335, 25310979; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="valyl-tRNA synthetase" /protein_id="NP_390687.2" /db_xref="EnsemblGenomes-Gn:BSU28090" /db_xref="EnsemblGenomes-Tr:CAB14769" /db_xref="GOA:Q05873" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002303" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR019499" /db_xref="InterPro:IPR033705" /db_xref="InterPro:IPR037118" /db_xref="SubtiList:BG10321" /db_xref="UniProtKB/Swiss-Prot:Q05873" /translation="METNEQTMPTKYDPAAVEKDRYDFWLKGKFFEAGSDQTKEPYSV VIPPPNVTGRLHLGHAWDTTLQDIVTRMKRMQGYDVLWLPGMDHAGIATQAKVEAKLR EEGKSRYDLGREKFLEETWKWKEEYADFIRSQWAKLGLGLDYSRERFTLDEGLSKAVR EVFVKLYEKGLIYRGEYIINWDPATKTALSDIEVIYKDVQGAFYHMSYPLADGSGSIE IATTRPETMLGDTAVAVHPEDERYKHLIGKTVILPIVNREIPIVGDDYVDMEFGSGAV KITPAHDPNDFELGNRHNLERILVMNEDGTMNENALQYQGMDRFECRKKLVKDLQEAG VLFKIEDHMHSVGHSERSGAVVEPYLSTQWFVRMQPLADAAIELQKKEEKVNFVPDRF EKTYLHWMENIRDWCISRQLWWGHRIPAWYHKETGELYVGLEAPEDSENWEQDTDVLD TWFSSALWPFSTMGWPDVTAEDFKRYYPTDVLVTGYDIIFFWVSRMIFQGIEFTGERP FKDVLIHGLIRDEQGRKMSKSLGNGVDPMDVIDKYGADSLRYFLATGSSPGQDLRFSY EKVESTWNFANKIWNASRFALMNMDGMTYDELDLSGEKSVADKWILTRLNETIEHVTQ LADRYEFGEVGRHLYNFIWDDFCDWYIEMAKLPLYGEDEAAKKTTRSILAYVLDQTMR LLHPFMPFLTEEIWQHLPHQGESITVSQWPAVVPEHTDTEAAADMKLLVELIRSVRNI RSEVNTPMSKQVELYIKTSTDEIASRLEANRSYVERFTNPSVLKIGTDIEAVDKAMTA VVSGAEVILPLEGLINIDEEIARLQKEFDKLTKEVERVQKKLGNEGFMKKAPAHVIDE EREKEKDYVAKRDAVQKRMAELKG*" /label="valS CDS" gene complement(2363436..2366078) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /label="valS gene" S_feature complement(2366079..2366137) /Source="Nicolas_S_feature" /locus_tag="new_2869307_2869365_c" /HighExp="G150, G180, LBGexp, Oxctl, G135, dia0, HPh, Lbexp, Paraq, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigEF" /TUshortPSig="1, 0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1061" misc_RNA complement(2366138..2366360) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /product="T-box riboswitch specific of valine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboV RNA" gene complement(2366138..2366360) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /label="tboV gene" downshifts complement(2366181) /Source="Nicolas_upshifts" /id="D1438" /incds=0 /nref=9 /ntot=27 /MaxReadThrough="6.76593" /MaxDrop="4.53149" /score="23.9897385" /energy="-20" /TU="U2171,U2173,U2176" /idTUdmin="U2176" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2366389..2366408) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2366401) /Source="Nicolas_upshifts" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2366403..2366511) /Source="Nicolas_S_feature" /locus_tag="new_2869631_2869739_c" /HighExp="S8, S6, S7, S5, B36, LoTm, S4, S3, BT, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigEF" /TUshortPSig="0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1062" promotor_-35 complement(2366423..2366428) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2366465..2366474 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2366487..2366506 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2366488 /Source="Nicolas_upshifts" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2366504..2366518) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2366511) /Source="Nicolas_upshifts" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2366526..2366530) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2366526..2366717 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097770.1" /db_xref="EnsemblGenomes-Gn:BSU28099" /db_xref="EnsemblGenomes-Tr:CAX52676" /db_xref="GOA:C0H465" /db_xref="UniProtKB/Swiss-Prot:C0H465" /translation="MKKRFSSYSLPPWVRQIRLVSAQVIIPITIFQGIRTIFFPTTFD VLLLAILIFLACALHLEWI*" /label="yszA CDS" gene 2366526..2366717 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /label="yszA gene" CDS complement(2366736..2367761) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16371471, 16390444, 22091839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16371471, 16390444, 22091839; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390688.1" /db_xref="EnsemblGenomes-Gn:BSU28100" /db_xref="EnsemblGenomes-Tr:CAB14770" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014253" /db_xref="SubtiList:BG10347" /db_xref="UniProtKB/Swiss-Prot:P37964" /translation="MEDTQSVLQEYGLTAQFIEPVSPLVWKVYTDYGIFALKKLKEGR GKHFTDHMVAIEEKGFRSFVPVYRTNSGEFFSAGIQYGDIYYLMPWLQFDQEEERDQK HAYLFRETARLHERTAQELKVRRDEIERYYGQTKKKWEQDKIFYEQFVDRAEKEWYLS PFELQAITYFSETISAVNFALERLEDWYESAKEKDVSRVVMNHGSLSIHHFLYNDAGT GYFTNFERASVGPPQNDLLGFYTKMFRGFPKACPECVEWFYGYTKSFPLREAEVSLFL SYMAYPAAMYKVLNGYQTGKRQHEKEECTQLLKAYWQMKNIEPFVMKIHQIEQEKKFQ AENESTS*" /label="cotN CDS" gene complement(2366736..2367761) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /label="cotN gene" downshifts complement(2366766) /Source="Nicolas_upshifts" /id="D1439" /incds=0 /nref=23 /ntot=70 /MaxReadThrough="4.44965" /MaxDrop="6.68961" /score="-7.46388093" /energy="-12.1" /TU="U2176" /idTUdmin="U2176" /TUdmin="-1311" /isTUend="FALSE" /label="downshifts" CDS complement(2367794..2369521) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11325931, 16371471, 16950916, 22773792, 23178679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325931, 16371471, 16950916, 22773792, 23178679; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenetic spore protein (stage VI sporulation)" /protein_id="NP_390689.1" /db_xref="EnsemblGenomes-Gn:BSU28110" /db_xref="EnsemblGenomes-Tr:CAB14771" /db_xref="GOA:P37963" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10346" /db_xref="UniProtKB/Swiss-Prot:P37963" /translation="MPQNHRLQFSVEESICFQKGQEVSELLSISLDPDIRVQEVNDYV SIIGSLELTGEYNIDQNKHTEEIYTDKRFVEQVRKREDGSAELTHCFPVDITIPKNKV SHLQDVFVFIDAFDYQLTDSRILTIQADLAIEGLLDDTQDKEPEIPLYEAPAAFREEE LSEPPAHSVVEEPGASSAEEAVLQHEPPAEPPELFISKAGLREELETEKAESEPPESV ASEPEAREDVKEEEESEELAVPETEVRAESETEESEPEPDPSEIEIQEIVKAKKETAE PAAAIADVREEADSPAETELREHVGAEESPALEAELHSETVIAKEKEETTVSPNHEYA LRQEAQNEEAAQSDQADPALCQEEAEPDEALESVSEAALSIEDSRETASAVYMENDNA DLHFHFNQKTSSEEASQEELPEPAYRTFLPEQEEEDSFYSAPKLLEEEEQEEESFEIE VRKTPSAEEPKEETPFQSFQLPESSETERKETDAVPRVAPAAETKEPQTKESDNSLYL TKLFTKEADEFSRMKICIVQQEDTIERLCERYEITSQQLIRMNSLALDDELKAGQILY IPQYKNSHA*" /label="spoVID CDS" gene complement(2367794..2369521) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /label="spoVID gene" promotor_-35 2369123..2369126 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2369142..2369161 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2369148 /Source="Nicolas_upshifts" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2369517..2369521 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2369530..2369544 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2369544 /Source="Nicolas_upshifts" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2369559..2369577) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-10" upshifts complement(2369575) /Source="Nicolas_upshifts" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="upshifts" promotor_-35 complement(2369593..2369598) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-35" CDS complement(2369652..2370944) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 12029044, 15802251, 16682782, 20946885, 27303897" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 12029044, 15802251, 16682782, 20946885, 27303897; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde 2,1-aminomutase" /protein_id="NP_390690.1" /db_xref="EnsemblGenomes-Gn:BSU28120" /db_xref="EnsemblGenomes-Tr:CAB14772" /db_xref="GOA:P30949" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3BS8" /db_xref="SubtiList:BG10345" /db_xref="UniProtKB/Swiss-Prot:P30949" /translation="MRSYEKSKTAFKEAQKLMPGGVNSPVRAFKSVDMDPIFMERGKG SKIFDIDGNEYIDYVLSWGPLILGHTNDRVVESLKKVAEYGTSFGAPTEVENELAKLV IDRVPSVEIVRMVSSGTEATMSALRLARGYTGRNKILKFEGCYHGHGDSLLIKAGSGV ATLGLPDSPGVPEGIAKNTITVPYNDLESVKLAFQQFGEDIAGVIVEPVAGNMGVVPP QEGFLQGLRDITEQYGSLLIFDEVMTGFRVDYNCAQGYFGVTPDLTCLGKVIGGGLPV GAYGGKAEIMEQIAPSGPIYQAGTLSGNPLAMTAGLETLKQLTPESYKNFIKKGDRLE EGISKTAGAHGIPHTFNRAGSMIGFFFTNEPVINYETAKSSDLKLFASYYKGMANEGV FLPPSQFEGLFLSTAHTDEDIENTIQAAEKVFAEISRR*" /label="hemL CDS" gene complement(2369652..2370944) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /label="hemL gene" downshifts complement(2369669) /Source="Nicolas_upshifts" /id="D1440" /incds=0 /nref=144 /ntot=397 /MaxReadThrough="3.40168" /MaxDrop="7.29251" /score="3.77738386" /energy="-10.6" /TU="NA" /idTUdmin="U2177" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2370974..2371948) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /EC_number="4.2.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 12029044, 15802251, 20823524, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 12029044, 15802251, 20823524, 24598743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-aminolevulinic acid dehydratase (porphobilinogen synthase)" /protein_id="NP_390691.1" /db_xref="EnsemblGenomes-Gn:BSU28130" /db_xref="EnsemblGenomes-Tr:CAB14773" /db_xref="GOA:P30950" /db_xref="InterPro:IPR001731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR030656" /db_xref="SubtiList:BG10344" /db_xref="UniProtKB/Swiss-Prot:P30950" /translation="MSQSFNRHRRLRTSKAMREMVKETRLHPSDFIYPIFVVEGLEGK KAVPSMPDVHHVSLDLLKDEVAELVKLGIQSVIVFGIPEEKDDCGTQAYHDHGIVQKA ITEIKEHFPEMVVVADTCLCEYTDHGHCGLVKDGVILNDESLELLAQTAVSQAKAGAD IIAPSNMMDGFVTVIREALDKEGFVNIPIMSYAVKYSSEFYGPFRDAANSTPQFGDRK TYQMDPANRMEALREAQSDVEEGADFLIVKPSLSYMDIMRDVKNEFTLPLVAYNVSGE YSMVKAAAQNGWIKEKEIVLEILTSMKRAGADLIITYHAKDAAKWLAE*" /label="hemB CDS" gene complement(2370974..2371948) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /label="hemB gene" CDS complement(2371945..2372733) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /EC_number="4.2.1.75" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 2110138, 7628476, 12029044, 12196144, 15802251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 2110138, 7628476, 12029044, 12196144, 15802251; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III cosynthase" /protein_id="NP_390692.1" /db_xref="EnsemblGenomes-Gn:BSU28140" /db_xref="EnsemblGenomes-Tr:CAB14774" /db_xref="GOA:P21248" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG10343" /db_xref="UniProtKB/Swiss-Prot:P21248" /translation="MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFR RALPNDVAEQVREDLAAPGWLVFTSVNGADFFFSYLKENQLILPAHKKIAAVGEKTAR RLKMHNVSVDVMPQEYIAEQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEV KEWVLYETIPDEEGIEALKDAAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTA CISIGPLTNDALLTYGITSHTPDTFTIDGMLELMCSMSREEERI*" /label="hemD CDS" gene complement(2371945..2372733) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /label="hemD gene" CDS complement(2372723..2373667) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /EC_number="2.5.1.61" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 9058548, 12029044, 15802251, 23908040, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 9058548, 12029044, 15802251, 23908040, 24598743; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="porphobilinogen deaminase (hydroxymethylbilane synthase)" /protein_id="NP_390693.1" /db_xref="EnsemblGenomes-Gn:BSU28150" /db_xref="EnsemblGenomes-Tr:CAB14775" /db_xref="GOA:P16616" /db_xref="InterPro:IPR000860" /db_xref="InterPro:IPR022417" /db_xref="InterPro:IPR022418" /db_xref="InterPro:IPR022419" /db_xref="InterPro:IPR036803" /db_xref="SubtiList:BG10342" /db_xref="UniProtKB/Swiss-Prot:P16616" /translation="MMRTIKVGSRRSKLAMTQTKWVIQKLKEINPSFAFEIKEIVTKG DRIVDVTLSKVGGKGLFVKEIEQALLNEEIDMAVHSMKDMPAVLPEGLVIGCIPERED PRDALISKNRVKLSEMKKGAVIGTSSLRRSAQLLIERPDLTIKWIRGNIDTRLQKLET EDYDAIILAAAGLSRMGWKQDVVTEFLEPERCLPAVGQGALAIECRESDEELLALFSQ FTDEYTKRTVLAERAFLNAMEGGCQVPIAGYSVLNGQDEIEMTGLVASPDGKIIFKET VTGNDPEEVGKRCAALMADKGAKDLIDRVKRELDEDGK*" /label="hemC CDS" gene complement(2372723..2373667) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /label="hemC gene" CDS complement(2373700..2374530) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8012594, 12029044, 15802251, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012594, 12029044, 15802251, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="negative effector of the concentration of glutamyl-tRNA reductase HemA" /protein_id="NP_390694.2" /db_xref="EnsemblGenomes-Gn:BSU28160" /db_xref="EnsemblGenomes-Tr:CAB14776" /db_xref="GOA:P16645" /db_xref="InterPro:IPR002541" /db_xref="SubtiList:BG10341" /db_xref="UniProtKB/Swiss-Prot:P16645" /translation="MIDTAMARLNEGTIVIYALSVLFYFIDFLQHNRKAGKMAFWLLS IVWTLQTVYLAYFMWVTGRFPVLNVTEALYFYAWVLVTLSLVLTKLLRVDFIVFFTNV IGFSMIAIHTFSPTEQQSAAFSGQLVSELLVIHITMAILSYGAFSLSFVFSVLYMFQY HLLKKKKWGKWLLRIEDLSKLDYMAYVLNVIGVPMLLLSLILGVIWAYVSLETLYWFD AKVLGSFVVLLLYSYYLYIRLIKELQGKVAALWNTACFLVLMINYFLLGSLSQFHWFS *" /label="hemX CDS" gene complement(2373700..2374530) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /label="hemX gene" CDS complement(2374538..2375905) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /EC_number="1.2.1.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1536660, 15802251, 1672867, 2490162, 12029044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1536660, 15802251, 1672867, 2490162, 12029044; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA reductase" /protein_id="NP_390695.1" /db_xref="EnsemblGenomes-Gn:BSU28170" /db_xref="EnsemblGenomes-Tr:CAB14777" /db_xref="GOA:P16618" /db_xref="InterPro:IPR000343" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR015895" /db_xref="InterPro:IPR015896" /db_xref="InterPro:IPR018214" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036343" /db_xref="InterPro:IPR036453" /db_xref="SubtiList:BG10340" /db_xref="UniProtKB/Swiss-Prot:P16618" /translation="MHILVVGVDYKSAPIEIREKVSFQPNELAEAMVQLKEEKSILEN IIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLSKEELSPFLTFYESDAAVEHLFR VACGLDSMVIGETQILGQVRDSFKTAQQEKTIGTIFNELFKQAVTVGKRTHAETDIGS NAVSVSYAAVELAKKIFGNLSSKHILILGAGKMGELAAENLHGQGIGKVTVINRTYLK AKELADRFSGEARSLNQLESALAEADILISSTGASEFVVSKEMMENANKLRKGRPLFM VDIAVPRDLDPALNDLEGVFLYDIDDLEGIVEANMKERRETAEKVELLIEETIVEFKQ WMNTLGVVPVISALREKALAIQSETMDSIERKLPHLSTREKKLLNKHTKSIINQMLRD PILKVKELAADADSEEKLALFMQIFDIEEAAGRQMMKTVESSQKVHSFKKAESKAGFS PLVSE*" /label="hemA CDS" gene complement(2374538..2375905) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /label="hemA gene" misc_feature complement(2375969..2375988) /Source="Nicolas_upshift_promotors" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2375975) /Source="Nicolas_upshifts" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2375977..2376066) /Source="Nicolas_S_feature" /locus_tag="new_2879205_2879294_c" /HighExp="dia15, Salt, dia5, Etha, Paraq, H2O2, Diami, Heat, LoTm, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigGF" /TUshortPSig="0.997, 1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1063" misc_feature 2376026..2376045 /Source="Nicolas_upshift_promotors" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2376034 /Source="Nicolas_upshifts" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2376063..2376082) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2376066) /Source="Nicolas_upshifts" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2376068..2376484) /Source="Nicolas_S_feature" /locus_tag="new_2879296_2879712_c" /HighExp="Etha, S5, Gly, S7, S4, S8, S6, H2O2, dia15, G135" /AntisenseName="ysxD" /AntisenseCor="-1.16761021676615E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF" /TUshortPSig="1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1064" promotor_-35 complement(2376093..2376101) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2376135..2376632 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390696.2" /db_xref="EnsemblGenomes-Gn:BSU28180" /db_xref="EnsemblGenomes-Tr:CAB14778" /db_xref="GOA:P40736" /db_xref="SubtiList:BG11068" /db_xref="UniProtKB/Swiss-Prot:P40736" /translation="MKQKSILFPCLLLAASVYAWLESGQAELFSGQDQWPVLLMLLGA AFVYQGKKEAVTPHFFIGLLLFGIGLHFFAKPKWVWWPDDFEMLLFMIGFSLLVSTVQ KKEYVYEAVSMICFSLFLYFFKQIMAWLESAHIPTALLKEYWPFVFIGISLLLLLIKR KKSIR*" /label="ysxD CDS" gene 2376135..2376632 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /label="ysxD gene" promotor_-10 complement(2376468..2376486) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2376484) /Source="Nicolas_upshifts" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2376486..2376616) /Source="Nicolas_S_feature" /locus_tag="new_2879714_2879844_c" /HighExp="S5, S4, S8, S6, H2O2, S7, Etha, dia15, Diami, G180" /AntisenseName="ysxD" /AntisenseCor="-1.18079537254433E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1065" promotor_-35 complement(2376502..2376508) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2376596..2376607) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-10" upshifts complement(2376616) /Source="Nicolas_upshifts" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="upshifts" promotor_-35 complement(2376622..2376628) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-35" CDS complement(2376654..2377241) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome 50S subunit assembly(maturation of the central 50S protuberance)" /protein_id="NP_390697.1" /db_xref="EnsemblGenomes-Gn:BSU28190" /db_xref="EnsemblGenomes-Tr:CAB14779" /db_xref="GOA:P38424" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019987" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030393" /db_xref="PDB:1SUL" /db_xref="PDB:1SVI" /db_xref="PDB:1SVW" /db_xref="SubtiList:BG10339" /db_xref="UniProtKB/Swiss-Prot:P38424" /translation="MKVTKSEIVISAVKPEQYPEGGLPEIALAGRSNVGKSSFINSLI NRKNLARTSSKPGKTQTLNFYIINDELHFVDVPGYGFAKVSKSEREAWGRMIETYITT REELKAVVQIVDLRHAPSNDDVQMYEFLKYYGIPVIVIATKADKIPKGKWDKHAKVVR QTLNIDPEDELILFSSETKKGKDEAWGAIKKMINR*" /label="engB CDS" gene complement(2376654..2377241) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /label="engB gene" downshifts complement(2376682) /Source="Nicolas_upshifts" /id="D1441" /incds=0 /nref=78 /ntot=212 /MaxReadThrough="4.03888" /MaxDrop="6.16077" /score="19.8235959" /energy="-13.4" /TU="NA" /idTUdmin="U2182" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2377238..2379562) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /EC_number="3.4.21.53" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="class III heat-shock ATP-dependent LonA protease" /protein_id="NP_390698.1" /db_xref="EnsemblGenomes-Gn:BSU28200" /db_xref="EnsemblGenomes-Tr:CAB14780" /db_xref="GOA:P37945" /db_xref="InterPro:IPR003111" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004815" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027543" /db_xref="PDB:1X37" /db_xref="PDB:3M65" /db_xref="PDB:3M6A" /db_xref="SubtiList:BG10338" /db_xref="UniProtKB/Swiss-Prot:P37945" /translation="MAEELKRSIPLLPLRGLLVYPTMVLHLDVGRDKSVQALEQAMMH DHMIFLATQQDISIDEPGEDEIFTVGTYTKIKQMLKLPNGTIRVLVEGLKRAHIVKYN EHEDYTSVDIQLIHEDDSKDTEDEALMRTLLDHFDQYIKISKKISAETYAAVTDIEEP GRMADIVASHLPLKLKDKQDILETADVKDRLNKVIDFINNEKEVLEIEKKIGQRVKRS MERTQKEYYLREQMKAIQKELGDKEGKTGEVQTLTEKIEEAGMPDHVKETALKELNRY EKIPSSSAESSVIRNYIDWLVALPWTDETDDKLDLKEAGRLLDEEHHGLEKVKERILE YLAVQKLTKSLKGPILCLAGPPGVGKTSLAKSIAKSLGRKFVRISLGGVRDESEIRGH RRTYVGAMPGRIIQGMKKAGKLNPVFLLDEIDKMSSDFRGDPSSAMLEVLDPEQNSSF SDHYIEETFDLSKVLFIATANNLATIPGPLRDRMEIINIAGYTEIEKLEIVKDHLLPK QIKEHGLKKSNLQLRDQAILDIIRYYTREAGVRSLERQLAAICRKAAKAIVAEERKRI TVTEKNLQDFIGKRIFRYGQAETEDQVGVVTGLAYTTVGGDTLSIEVSLSPGKGKLIL TGKLGDVMRESAQAAFSYVRSKTEELGIEPDFHEKYDIHIHVPEGAVPKDGPSAGITM ATALVSALTGRAVSREVGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEK DIEDIPESVREGLTFILASHLDEVLEHALVGEKK*" /label="lonA CDS" gene complement(2377238..2379562) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /label="lonA gene" S_feature complement(2379563..2379674) /Source="Nicolas_S_feature" /locus_tag="new_2882791_2882902_c" /HighExp="Etha, dia15, LBGtran, dia5, Diami, H2O2, LBGexp, Lbexp, LoTm, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.967" /TUlongSig="NA" /TUlongPSig="NA" /label="S1066" promotor_-10 complement(2379659..2379678) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2379674) /Source="Nicolas_upshifts" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2379692..2379699) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2379743..2381401) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 18689473, 26428922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 18689473, 26428922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific ATP-dependent protease LonB" /protein_id="NP_390699.1" /db_xref="EnsemblGenomes-Gn:BSU28210" /db_xref="EnsemblGenomes-Tr:CAB14781" /db_xref="GOA:P42425" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014251" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11077" /db_xref="UniProtKB/Swiss-Prot:P42425" /translation="MSWTGIALFIQLFFGIIIGLYFWNLLKNQRTQKVTIDKESKKEM EQLRKMRAISLSEPLSEKVRPKSFKDIVGQEDGIKALKAALCGPNPQHVIVYGPPGVG KTAAARLVLEEAKKHKQSPFKEQAVFVELDATTARFDERGIADPLIGSVHDPIYQGAG AMGQAGIPQPKQGAVTHAHGGVLFIDEIGELHPIQMNKMLKVLEDRKVFLDSAYYSEE NTQIPNHIHDIFQNGLPADFRLIGATTRMPNEIPPAIRSRCLEVFFRELEKDELKTVA KTAADKIEKNISEEGLDLLTSYTRNGREAVNMIQIAAGMAVTENRKDITIEDIEWVIH SSQLTPKHEQKIGVEPQVGIVNGLAVYGPNSGSLLEIEVSVTAAQDKGSINITGIAEE ESIGSQSKSIRRKSMAKGSVENVLTVLRTMGMKPSDYDIHINFPGGIPIDGPSAGIAM AAGIFSAIHKIPIDNTVAMTGEISLNGLVKPIGGVIPKIKAAKQSGAKKVIIPYENQQ AILKQIDGIEIIAVKTFQEVLDEILVNPPTEQKPFHIEINKESV*" /label="lonB CDS" gene complement(2379743..2381401) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /label="lonB gene" downshifts complement(2379762) /Source="Nicolas_upshifts" /id="D1442" /incds=0 /nref=24 /ntot=42 /MaxReadThrough="2.32825" /MaxDrop="4.82102" /score="7.30551887" /energy="-7.1" /TU="NA" /idTUdmin="U2183" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2381445..2381463) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2381456) /Source="Nicolas_upshifts" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2381479..2381484) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2381553..2382815) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein unfolding ATPase required for presentation of proteins to proteases; Maxwell's demon" /protein_id="NP_390700.2" /db_xref="EnsemblGenomes-Gn:BSU28220" /db_xref="EnsemblGenomes-Tr:CAB14782" /db_xref="GOA:P50866" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004487" /db_xref="InterPro:IPR010603" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11387" /db_xref="UniProtKB/Swiss-Prot:P50866" /translation="MFKFNEEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCTE IVEEELGTEEEVEFKDVPKPQEIREILNEYVIGQDQAKKSLAVAVYNHYKRINSNSKV DDVELSKSNISLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILL KLIQAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVAS VPPQGGRKHPHQEFIQIDTTNILFICGGAFDGIEQIIKRRLGQKVIGFGADNKAADLE KEDLLSKVLPEDLLRFGLIPEFIGRLPVIASLEKLDEEALVAILTKPKNALVKQFKKM LELDNVELEFEEEALSEIAKKAIERKTGARGLRSIIEGIMLDVMFELPSRDDIEKCVI TGATVTHGEPPRLLLKDGTEVSQDKTSA*" /label="clpX CDS" gene complement(2381553..2382815) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /label="clpX gene" downshifts complement(2381563) /Source="Nicolas_upshifts" /id="D1443" /incds=0 /nref=256 /ntot=333 /MaxReadThrough="2.8818" /MaxDrop="7.82186" /score="40.299167" /energy="-18.9" /TU="U2185" /idTUdmin="U2184" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2382816..2382905) /Source="Nicolas_S_feature" /locus_tag="new_2886044_2886133_c" /HighExp="dia15, dia5, Salt, Diami, C90, H2O2, Paraq, Oxctl, S1, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="1, 0.998, 0.896" /label="S1067" promotor_-10 complement(2382893..2382912) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2382905) /Source="Nicolas_upshifts" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2382907..2383038) /Source="Nicolas_S_feature" /locus_tag="new_2886135_2886266_c" /HighExp="H2O2, dia15, Paraq, Oxctl, G180, G135, HPh, G150, LPh, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1068" promotor_-35 complement(2382924..2382931) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2383083) /Source="Nicolas_upshifts" /id="D1444" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="8.26501" /MaxDrop="4.34985" /score="-0.284489083" /energy="-10.7" /TU="U2185,U2190" /idTUdmin="U2190" /TUdmin="-153" /isTUend="FALSE" /label="downshifts" CDS complement(2383087..2384361) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9748346, 12224648, 16156784, 17021213" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9748346, 12224648, 16156784, 17021213; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl isomerase (trigger factor)" /protein_id="NP_390701.1" /db_xref="EnsemblGenomes-Gn:BSU28230" /db_xref="EnsemblGenomes-Tr:CAB14783" /db_xref="GOA:P80698" /db_xref="InterPro:IPR001179" /db_xref="InterPro:IPR005215" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR008881" /db_xref="InterPro:IPR027304" /db_xref="InterPro:IPR036611" /db_xref="SubtiList:BG19023" /db_xref="UniProtKB/Swiss-Prot:P80698" /translation="MSVKWEKQEGNEGVLTVEVDAETFKTALDDAFKKVVKQVSIPGF RKGKIPRGLFEQRFGVEALYQDALDILLPVEYPKAVEEAGIEPVDRPEIDVEKIEKGE SLIFTAKVTVKPEVKLGEYKGLGIEKDDTTVTDEDVQNELKALQERQAELVVKEEGAV EEGNTVVLDFEGFVDGEAFEGGKAENYSLEVGSGSFIPGFEDQLVGLEAGAEKDVEVT FPEEYHAEDLAGKPAVFKVKIHEIKAKELPELDDEFAKDIDEEVETLAELTEKTKKRL EEAKENEADAKLREELVLKASENAEIDVPQAMVDTELDRMLKEFEQRLQMQGMNLELY TQFSGQDEAALKEQMKEDAEKRVKSNLTLEAIAKAENLEVSDEEVDAELTKMAEAYNM PVENIKQAIGSTDAMKEDLKVRKAIDFLVENR*" /label="tig CDS" gene complement(2383087..2384361) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /label="tig gene" S_feature complement(2384362..2384551) /Source="Nicolas_S_feature" /locus_tag="new_2887590_2887779_c" /HighExp="H2O2, HPh, BMM, dia15, T-4.40H, G180, Paraq, Oxctl, LBGexp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1069" promotor_-10 complement(2384538..2384557) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2384551) /Source="Nicolas_upshifts" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2384572..2384576) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2384589..2385593) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390702.2" /db_xref="EnsemblGenomes-Gn:BSU28240" /db_xref="EnsemblGenomes-Tr:CAB14784" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12338" /db_xref="UniProtKB/Swiss-Prot:P94569" /translation="MTHDKKNAKIIPFPHLKDRLVEKGMSSLKEKKYQEALELFSEAM KYDDTESDLHLGMAICFLELGELEEAESVCEKMLKEGYGHYFTVLQVYMTILIQLKKY EEVKSTIEAVLEENQLPAESAEQFYKLLDFSRKMTDPDREDEAWAEEYEDTIDTEKVL ASPEEQMNLIHSLKDRNVAKYTGLLKTILQDPSAHPIIKTMIVMLLAEHEYSKPVHIS KFGESLTIEPSEIVPPDAAPILHRVLRVLDETLGNENPTLYAAVEELWRRHLYVLYPF QPKLLSADLWAAALHKVGYEMHGIEIESEELHMMYEFTDRELDEACTMLKDIEEISYL *" /label="ysoA CDS" gene complement(2384589..2385593) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /label="ysoA gene" promotor_-10 complement(2385618..2385637) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2385636) /Source="Nicolas_upshifts" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2385649..2385656) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" CDS complement(2385712..2386311) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (small subunit)" /protein_id="NP_390703.1" /db_xref="EnsemblGenomes-Gn:BSU28250" /db_xref="EnsemblGenomes-Tr:CAB14785" /db_xref="GOA:P94568" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR004431" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR033940" /db_xref="SubtiList:BG11950" /db_xref="UniProtKB/Swiss-Prot:P94568" /translation="MEPLKSHTGKAAVLNRINVDTDQIIPKQFLKRIERTGYGRFAFF DWRYDANGEPNPEFELNQPVYQGASILIAGENFGCGSSREHAPWALDDYGFKIIIAPS FADIFHQNCFKNGMLPIRMPYDNWKQLVGQYENQSLQMTVDLENQLIHDSEGNQISFE VDPHWKEMLINGYDEISLTLLLEDEIKQFESQRSSWLQA*" /label="leuD CDS" gene complement(2385712..2386311) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /label="leuD gene" downshifts complement(2385733) /Source="Nicolas_upshifts" /id="D1445" /incds=0 /nref=5 /ntot=111 /MaxReadThrough="6.76876" /MaxDrop="3.81278" /score="12.2084487" /energy="-9.9" /TU="U2190,U2191" /idTUdmin="U2186" /TUdmin="-1176" /isTUend="FALSE" /label="downshifts" CDS complement(2386324..2387742) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (large subunit)" /protein_id="NP_390704.1" /db_xref="EnsemblGenomes-Gn:BSU28260" /db_xref="EnsemblGenomes-Tr:CAB14786" /db_xref="GOA:P80858" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR004430" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR033941" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG11949" /db_xref="UniProtKB/Swiss-Prot:P80858" /translation="MMPRTIIEKIWDQHIVKHGEGKPDLLYIDLHLIHEVTSPQAFEG LRQKGRKVRRPQNTFATMDHNIPTVNRFEIKDEVAKRQVTALERNCEEFGVRLADLHS VDQGIVHVVGPELGLTLPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLSTQTLWQ QRPKTLEVRVDGTLQKGVTAKDVILAVIGKYGVKFGTGYVIEYTGEVFRNMTMDERMT VCNMSIEAGARAGLIAPDEVTFEYCKNRKYTPKGEEFDKAVEEWKALRTDPGAVYDKS IVLDGNKISPMVTWGINPGMVLPVDSEVPAPESFSAEDDKKEAIRAYEYMGLTPHQKI EDIKVEHVFIGSCTNSRMTDLRQAADMIKGKKVADSVRAIVVPGSQSVKLQAEKEGLD QIFLEAGFEWRESGCSMCLSMNNDVVPEGERCASTSNRNFEGRQGKGARTHLVSPAMA AMAAIHGHFVDVRKFYQEKTVV*" /label="leuC CDS" gene complement(2386324..2387742) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /label="leuC gene" promotor_-35 2387631..2387635 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2387650..2387654 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2387650 /Source="Nicolas_upshifts" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2387792..2388889) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /EC_number="1.1.1.85" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10095787, 15228537, 15916605, 17389690" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10095787, 15228537, 15916605, 17389690; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydrogenase" /protein_id="NP_390705.2" /db_xref="EnsemblGenomes-Gn:BSU28270" /db_xref="EnsemblGenomes-Tr:CAB14787" /db_xref="GOA:P05645" /db_xref="InterPro:IPR004429" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG10675" /db_xref="UniProtKB/Swiss-Prot:P05645" /translation="MKKRIALLPGDGIGPEVLESATDVLKSVAERFNHEFEFEYGLIG GAAIDEHHNPLPEETVAACKNADAILLGAVGGPKWDQNPSELRPEKGLLSIRKQLDLF ANLRPVKVFESLSDASPLKKEYIDNVDFVIVRELTGGLYFGQPSKRYVNTEGEQEAVD TLFYKRTEIERVIREGFKMAAARKGKVTSVDKANVLESSRLWREVAEDVAQEFPDVKL EHMLVDNAAMQLIYAPNQFDVVVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHL FEPVHGSAPDIAGKGMANPFAAILSAAMLLRTSFGLEEEAKAVEDAVNKVLASGKRTR DLARSEEFSSTQAITEEVKAAIMSENTISNV*" /label="leuB CDS" gene complement(2387792..2388889) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /label="leuB gene" CDS complement(2388910..2390466) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /EC_number="2.3.3.13" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 16330546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-isopropylmalate synthase" /protein_id="NP_390706.1" /db_xref="EnsemblGenomes-Gn:BSU28280" /db_xref="EnsemblGenomes-Tr:CAB14788" /db_xref="GOA:P94565" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR002034" /db_xref="InterPro:IPR005671" /db_xref="InterPro:IPR013709" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036230" /db_xref="SubtiList:BG11948" /db_xref="UniProtKB/Swiss-Prot:P94565" /translation="MRKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEA GFPASSRGDFLAVQEIARTIKNCSVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATS DIHLKHKLKMTREQVIERAVGMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDA GASVINLPDTVGYLAPAEYGNIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIE NGADQIECAVNGIGERAGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLT GMAVPRNKAVVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRH AFKDRLTALGFQFDSEEINKFFTMFKELTEKKKEITDEDLVSLILEEKVTDRKIGYEF LSLQVHYGTSQVPTATLSLKNQENAQLIQEAATGAGSVEAIYNTLERCIDKDVELLDY RIQSNRKGEDAFAQVYVRVLVNGKESAGRGIAQDVLEASAKAYLNAVNRQLVFQSNMS GLKNHTAVGS*" /label="leuA CDS" gene complement(2388910..2390466) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /label="leuA gene" promotor_-35 2389306..2389309 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2389322..2391763 /Source="Nicolas_S_feature" /locus_tag="new_2892550_2894991" /HighExp="Lbstat, C30, T0.30H, M9-stat, T1.30H, H2O2, M0t90, T2.0H, Salt, BC" /AntisenseName="ilvC" /AntisenseCor="-0.51305153097242795" /AntisenseRegPval="-18.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1070" upshifts 2389322 /Source="Nicolas_upshifts" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2389324..2389343 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2390453..2391481) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /EC_number="1.1.1.86" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 25393291, 25849365; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid isomeroreductase (NADP-dependent)" /protein_id="NP_390707.1" /db_xref="EnsemblGenomes-Gn:BSU28290" /db_xref="EnsemblGenomes-Tr:CAB14789" /db_xref="GOA:P37253" /db_xref="InterPro:IPR000506" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013023" /db_xref="InterPro:IPR013116" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR014359" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10672" /db_xref="UniProtKB/Swiss-Prot:P37253" /translation="MVKVYYNGDIKENVLAGKTVAVIGYGSQGHAHALNLKESGVDVI VGVRQGKSFTQAQEDGHKVFSVKEAAAQAEIIMVLLPDEQQQKVYEAEIKDELTAGKS LVFAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVTGEA RDKALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLSALVKAGFETLTEAGY QPELAYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKE VLKDIQNGTFAKEWIVENQVNRPRFNAINASENEHQIEVVGRKLREMMPFVKQGKKKE AVVSVAQN*" /label="ilvC CDS" gene complement(2390453..2391481) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /label="ilvC gene" CDS complement(2391505..2392023) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (small subunit)" /protein_id="NP_390708.2" /db_xref="EnsemblGenomes-Gn:BSU28300" /db_xref="EnsemblGenomes-Tr:CAB14790" /db_xref="GOA:P37252" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004789" /db_xref="InterPro:IPR019455" /db_xref="SubtiList:BG10671" /db_xref="UniProtKB/Swiss-Prot:P37252" /translation="MKRIITLTVVNRSGVLNRITGLFTKRHYNIESITVGHTETAGVS RITFVVHVEGENDVEQLTKQLNKQIDVLKVTDITNQSIVQRELALIKVVSAPSTRTEI NGIIEPFRASVVDVSRDSIVVQVTGESNKIEALIELLKPYGIKEIARTGTTAFARGTQ QKASSNKTISIV*" /label="ilvH CDS" gene complement(2391505..2392023) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /label="ilvH gene" promotor_-35 2391744..2391747 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2391763..2391767 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2391765 /Source="Nicolas_upshifts" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2392020..2393744) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (large subunit)" /protein_id="NP_390709.1" /db_xref="EnsemblGenomes-Gn:BSU28310" /db_xref="EnsemblGenomes-Tr:CAB14791" /db_xref="GOA:P37251" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012846" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10670" /db_xref="UniProtKB/Swiss-Prot:P37251" /translation="MGTNVQVDSASAECTQTMSGALMLIESLKKEKVEMIFGYPGGAV LPIYDKLYNSGLVHILPRHEQGAIHAAEGYARVSGKPGVVIATSGPGATNLVTGLADA MIDSLPLVVFTGQVATSVIGSDAFQEADILGITMPVTKHSYQVRQPEDLPRIIKEAFH IATTGRPGPVLIDIPKDVATIEGEFSYDHEMNLPGYQPTTEPNYLQIRKLVEAVSSAK KPVILAGAGVLHGKASEELKNYAEQQQIPVAHTLLGLGGFPADHPLFLGMAGMHGTYT ANMALHECDLLISIGARFDDRVTGNLKHFARNAKIAHIDIDPAEIGKIMKTQIPVVGD SKIVLQELIKQDGKQSDSSEWKKQLAEWKEEYPLWYVDNEEEGFKPQKLIEYIHQFTK GEAIVATDVGQHQMWSAQFYPFQKADKWVTSGGLGTMGFGLPAAIGAQLAEKDATVVA VVGDGGFQMTLQELDVIRELNLPVKVVILNNACLGMVRQWQEIFYEERYSESKFASQP DFVKLSEAYGIKGIRISSEAEAKEKLEEALTSREPVVIDVRVASEEKVFPMVAPGKGL HEMVGVKP*" /label="ilvB CDS" gene complement(2392020..2393744) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /label="ilvB gene" S_feature complement(2393745..2393865) /Source="Nicolas_S_feature" /locus_tag="new_2896973_2897093_c" /HighExp="T-5.40H, T-4.40H, S2, MG 120, Glucon, GM-0.2, T-2.40H, GM-0.1, HiOs, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1071" misc_RNA complement(2393866..2394112) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /product="T-box controlling synthesis of branched chain amino acids" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboILV RNA" gene complement(2393866..2394112) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /label="tboILV gene" downshifts complement(2393909) /Source="Nicolas_upshifts" /id="D1446" /incds=0 /nref=18 /ntot=78 /MaxReadThrough="7.67475" /MaxDrop="4.2339" /score="5.33237345" /energy="-13.8" /TU="U2190,U2191" /idTUdmin="U2195" /TUdmin=2682 /isTUend="FALSE" /label="downshifts" S_feature complement(2394113..2394239) /Source="Nicolas_S_feature" /locus_tag="new_2897341_2897467_c" /HighExp="LoTm, HiOs, T-3.40H, BC, B60, Pyr, GM 15, T-5.40H, UNK1, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1072" promotor_-10 complement(2394221..2394240) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-10" upshifts complement(2394239) /Source="Nicolas_upshifts" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="upshifts" S_feature complement(2394241..2394371) /Source="Nicolas_S_feature" /locus_tag="new_2897469_2897599_c" /HighExp="Cold, S8, S0, S7, Mal, S6, G135, M9-stat, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1073" promotor_-35 complement(2394255..2394262) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-35" promotor_-10 complement(2394366..2394385) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2394375) /Source="Nicolas_upshifts" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2394399..2394402) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" promotor_-35 2394497..2394506 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2394520..2394539 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2394522 /Source="Nicolas_upshifts" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="upshifts" CDS 2394560..2394895 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_390710.1" /db_xref="EnsemblGenomes-Gn:BSU28320" /db_xref="EnsemblGenomes-Tr:CAB14792" /db_xref="SubtiList:BG12335" /db_xref="UniProtKB/Swiss-Prot:P94563" /translation="MNKSFADMQGFPAGFPSFPNFPQQYYPAVPPFYQQSQQPFGGYG YGQPFSQAYSPLTTPSGMYSSFPYASGFYGQQFSGAGFSGHGGSLSAPAIHAGGFSGA PGVHGGFRY*" /label="cotQ CDS" gene 2394560..2394895 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /label="cotQ gene" downshifts 2394889 /Source="Nicolas_upshifts" /id="D1447" /incds=0 /nref=14 /ntot=36 /MaxReadThrough="3.79194" /MaxDrop="6.48183" /score="11.836855" /energy="-13" /TU="U2192" /idTUdmin="U2193" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-35 2394976..2394983 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2394997..2395016 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2394999..2395063 /Source="Nicolas_S_feature" /locus_tag="new_2898227_2898291" /HighExp="S5, S6, S8, S7, B36, S4, S3, B60, BT, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.954, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1074" upshifts 2394999 /Source="Nicolas_upshifts" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="upshifts" CDS 2395064..2395519 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17555270, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative indole acetic acid N-acetyltransferase" /protein_id="NP_390711.1" /db_xref="EnsemblGenomes-Gn:BSU28330" /db_xref="EnsemblGenomes-Tr:CAB14793" /db_xref="GOA:P94562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YX0" /db_xref="SubtiList:BG12336" /db_xref="UniProtKB/Swiss-Prot:P94562" /translation="MHIKIDDLTGRQVVSLVNEHLHSMTLMSPPESIHALGLEKLRGP EITFWSAWEGDELAGCGALKELDTRHGEIKSMRTSASHLRKGVAKQVLQHIIEEAEKR GYERLSLETGSMASFEPARKLYESFGFQYCEPFADYGEDPNSVFMTKKL*" /label="ysnE CDS" gene 2395064..2395519 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /label="ysnE gene" promotor_-35 2395627..2395633 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2395647..2395665 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2395654 /Source="Nicolas_upshifts" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="upshifts" CDS 2395703..2396524 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 27464829; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative stress response protein" /protein_id="NP_390712.3" /db_xref="EnsemblGenomes-Gn:BSU28340" /db_xref="EnsemblGenomes-Tr:CAB14794" /db_xref="InterPro:IPR019060" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG12337" /db_xref="UniProtKB/Swiss-Prot:P94560" /translation="MKSIVGVYETPQETIAAIEGLLTKGYDSDDISVVTSRRDTDYLE SRTGTEVNQAIDAHQDESESFFDKLKDYFTMDDTATHSKALSDLDIKTDEIDKYQEDL DDGKLLVAVDTDADVIAPIDNGNALSGGFSSTNELDYTTKEEKTMPLREEQLKVDKED VQTGEVEIGKEVKTEKRDMDIPVRHDEIYVERRPVDENKTDAAPVNDSEEIRVPIVEE KLEVTKKPVVTDEVVVGKRTVEENEHISETVKKEEPRLNKEGKVDGLDDDPLNNK*" /label="ysnF CDS" gene 2395703..2396524 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /label="ysnF gene" downshifts 2396517 /Source="Nicolas_upshifts" /id="D1448" /incds=0 /nref=8 /ntot=77 /MaxReadThrough="2.49244" /MaxDrop="8.12771" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts 2396581 /Source="Nicolas_upshifts" /id="D1449" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="1.26489" /MaxDrop="4.30778" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin=43 /isTUend="FALSE" /label="downshifts" tRNA complement(2396588..2396661) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg (UCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg2 tRNA" gene complement(2396588..2396661) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /label="trnSL-Arg2 gene" downshifts complement(2396622) /Source="Nicolas_upshifts" /id="D1450" /incds=0 /nref=34 /ntot=243 /MaxReadThrough="1.54905" /MaxDrop="4.72186" /score="24.0242272" /energy="-13.3" /TU="U2195,U2196" /idTUdmin="U2195" /TUdmin="-31" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2396698..2396717) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2396701) /Source="Nicolas_upshifts" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2396731..2396738) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2396792..2397301) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /EC_number="3.1.4.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390713.2" /db_xref="EnsemblGenomes-Gn:BSU28350" /db_xref="EnsemblGenomes-Tr:CAB14795" /db_xref="GOA:P94559" /db_xref="InterPro:IPR000979" /db_xref="InterPro:IPR020935" /db_xref="InterPro:IPR024654" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12334" /db_xref="UniProtKB/Swiss-Prot:P94559" /translation="MNVLIISDSHGLEEELQTIAKRHEAEVDLMIHCGDSELETRHPA LEPYAVVKGNCDFAGDFKDELLLTAGSRKILVTHGHLHGIKQTLLNVYYRAEELGADV ICFGHSHIAGSEVLRGKLMINPGSIRLPRVRRTESYAILTLENDAATVRFYDQAGNEI EDLQNRVTL*" /label="ysnB CDS" gene complement(2396792..2397301) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /label="ysnB gene" downshifts complement(2396809) /Source="Nicolas_upshifts" /id="D1451" /incds=0 /nref=87 /ntot=225 /MaxReadThrough="4.15666" /MaxDrop="5.59323" /score="24.0242272" /energy="-13.3" /TU="U2196,U2197" /idTUdmin="U2197" /TUdmin="-130" /isTUend="FALSE" /label="downshifts" CDS complement(2397317..2397913) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /EC_number="3.6.1.66" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16322510, 17090528, 17976651, 18689515, 19943897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyinosine/deoxyxanthosine triphosphate pyrophosphatase, promiscuous (subunit A)" /protein_id="NP_390714.1" /db_xref="EnsemblGenomes-Gn:BSU28360" /db_xref="EnsemblGenomes-Tr:CAB14796" /db_xref="GOA:P94558" /db_xref="InterPro:IPR002637" /db_xref="InterPro:IPR020922" /db_xref="InterPro:IPR029001" /db_xref="SubtiList:BG12333" /db_xref="UniProtKB/Swiss-Prot:P94558" /translation="MIIMKEAIIATHNPGKVKEFKEILEPRGYDVKSLAEIGFTEEIE ETGHTFEENAIMKAEAVAKAVNKMVIADDSGLSIDNLGGRPGVYSARYAGEQKDDQAN IEKVLSELKGIEKEQRTARFRCALAVSIPGEETKTVEGHVEGYIAEEPRGEYGFGYDP IFIVKDKDKTMAELTSDEKNKISHRADALKKLSKLLEA*" /label="rdgB CDS" gene complement(2397317..2397913) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /label="rdgB gene" CDS complement(2397926..2398663) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /EC_number="2.7.7.56" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1624460, 19153445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624460, 19153445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease PH" /protein_id="NP_390715.1" /db_xref="EnsemblGenomes-Gn:BSU28370" /db_xref="EnsemblGenomes-Tr:CAB14797" /db_xref="GOA:P28619" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR002381" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR018336" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="PDB:1OYP" /db_xref="PDB:1OYR" /db_xref="PDB:1OYS" /db_xref="SubtiList:BG10357" /db_xref="UniProtKB/Swiss-Prot:P28619" /translation="MRHDGRQHDELRPITFDLDFISHPEGSVLITAGNTKVICNASVE DRVPPFLRGGGKGWITAEYSMLPRATNQRTIRESSKGKISGRTMEIQRLIGRALRAVV DLEKLGERTIWIDCDVIQADGGTRTASITGAFLAMAIAIGKLIKAGTIKTNPITDFLA AISVGIDKEQGILLDLNYEEDSSAEVDMNVIMTGSGRFVELQGTGEEATFSREDLNGL LGLAEKGIQELIDKQKEVLGDSLPELK*" /label="rph CDS" gene complement(2397926..2398663) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /label="rph gene" promotor_-10 complement(2398745..2398764) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2398761) /Source="Nicolas_upshifts" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2398774..2399874) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14662349, 27381174" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14662349, 27381174; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination (cortex hydrolysis) and sporulation (stage II, multiple polar septa) lytic enzyme" /protein_id="NP_390716.1" /db_xref="EnsemblGenomes-Gn:BSU28380" /db_xref="EnsemblGenomes-Tr:CAB14798" /db_xref="GOA:P39072" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10356" /db_xref="UniProtKB/Swiss-Prot:P39072" /translation="MLKKGPAVIGATCLTSALLLSGCGLFQSDKAAEEIDPPQDVTFV NDEAGANSNTTAAKKTESEKSDTAKADQASSTVMRELYLIDKNGYVVAQTLPLPKSES TAKQALEYLVQGGPVSEILPNGFRAVLPADTTVNVDIKKDGTAIADFSNEFKNYKKED EQKIVQSVTWTLTQFSSIDKVKLRINGHELKEMPVGGTPISDDLSRKDGINLETAGVN DLTATHPLTVYYLAENEDSEYYVPVTKRIDNSEKDDITAAINELAKGPSKVSGLLTDF SEDVKLVSKPKIKDGRVTLDFNQSIFGSADEKTKMISSEVLNSIVLTLTEQPDVKSVS VKVNGKSELVNEKGEKLTEPVSRPSQVNTGSF*" /label="gerM CDS" gene complement(2398774..2399874) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /label="gerM gene" promotor_-35 complement(2398779..2398784) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2398791) /Source="Nicolas_upshifts" /id="D1452" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="5.80816" /MaxDrop="4.3535" /score="41.5916163" /energy="-13" /TU="U2197" /idTUdmin="U2198" /TUdmin=1209 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2399897..2399915) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2399913) /Source="Nicolas_upshifts" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2399930..2399935) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2399989..2400807) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /EC_number="5.1.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15347750, 17610893, 17720142, 19309142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390717.2" /db_xref="EnsemblGenomes-Gn:BSU28390" /db_xref="EnsemblGenomes-Tr:CAB14799" /db_xref="GOA:P94556" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="PDB:1ZUW" /db_xref="SubtiList:BG11964" /db_xref="UniProtKB/Swiss-Prot:P94556" /translation="MLEQPIGVIDSGVGGLTVAKEIMRQLPKENIIYVGDTKRCPYGP RPEEEVLQYTWELTNYLLENHHIKMLVIACNTATAIALDDIQRSVGIPVVGVIQPGAR AAIKVTDNQHIGVIGTENTIKSNAYEEALLALNPDLKVENLACPLLVPFVESGKFLDK TADEIVKTSLYPLKDTSIDSLILGCTHYPILKEAIQRYMGEHVNIISSGDETAREVST ILSYKGLLNQSPIAPDHQFLTTGARDQFAKIADDWFGHEVGHVECISLQEPIKR*" /label="rcmE CDS" gene complement(2399989..2400807) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /label="rcmE gene" downshifts complement(2400001) /Source="Nicolas_upshifts" /id="D1453" /incds=0 /nref=230 /ntot=265 /MaxReadThrough="0.9265" /MaxDrop="6.72492" /score="41.5916163" /energy="-13" /TU="NA" /idTUdmin="U2198" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2400815..2401255) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26577401; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (mother cell's gene expression during sporulation)" /protein_id="NP_390718.1" /db_xref="EnsemblGenomes-Gn:BSU28400" /db_xref="EnsemblGenomes-Tr:CAB14800" /db_xref="GOA:P97247" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12332" /db_xref="UniProtKB/Swiss-Prot:P97247" /translation="MTSKPLEHVADIEKSLRHIAAIIKQKGREILNQYAITPPQFVGL QWLYELGDMTIGELSGKMYLACSTTTDLIDRMQKNELVERVKDPADRRVVRIHLLPEG ERIIQEVITKRQEYLRDMFESFTDEEIAIFEKSLMKLQHEMKRK*" /label="ysmB CDS" gene complement(2400815..2401255) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /label="ysmB gene" promotor_-10 complement(2401298..2401317) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2401307) /Source="Nicolas_upshifts" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2401309..2401451) /Source="Nicolas_S_feature" /locus_tag="new_2904537_2904679_c" /HighExp="BT, B36, S6, S8, S7, B60, Pyr, G/S, Lbtran, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.121047" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1075" promotor_-35 complement(2401333..2401337) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2401496) /Source="Nicolas_upshifts" /id="D1454" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="6.16749" /MaxDrop="4.6532" /score="20.9204638" /energy="-10.8" /TU="U2200,U2202" /idTUdmin="U2202" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" CDS complement(2401499..2401723) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transcriptional regulator required for the expression of late spore coat genes" /protein_id="NP_390719.2" /db_xref="EnsemblGenomes-Gn:BSU28410" /db_xref="EnsemblGenomes-Tr:CAB14801" /db_xref="GOA:P11470" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1FSE" /db_xref="SubtiList:BG10355" /db_xref="UniProtKB/Swiss-Prot:P11470" /translation="MKEKEFQSKPLLTKREREVFELLVQDKTTKEIASELFISEKTVR NHISNAMQKLGVKGRSQAVVELLRMGELEL*" /label="gerE CDS" gene complement(2401499..2401723) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /label="gerE gene" upshifts 2401772 /Source="Nicolas_upshifts" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2401774..2401792 /Source="Nicolas_upshift_promotors" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2401781..2401800) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2401801) /Source="Nicolas_upshifts" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2401814..2401823) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2401839..2402282) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390720.1" /db_xref="EnsemblGenomes-Gn:BSU28420" /db_xref="EnsemblGenomes-Tr:CAB14802" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10354" /db_xref="UniProtKB/Swiss-Prot:P11469" /translation="MKLPAYIDMPFQEWKTSFSFFNKVSVRFSETDMFGHMNNVTPFI YFEEVRISYFKKLNMMSENKQTMTVVASQQCDYLRQVMPYEELRIYVKTSAVGSSSLT LHYLGENLEGEPCFTGAVVMVQVSKESGKAVSWTDEEKETLLHTR*" /label="ysmA CDS" gene complement(2401839..2402282) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /label="ysmA gene" CDS complement(2402343..2403104) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 22720735, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 22720735, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (iron-sulfur protein)" /protein_id="NP_390721.1" /db_xref="EnsemblGenomes-Gn:BSU28430" /db_xref="EnsemblGenomes-Tr:CAB14803" /db_xref="GOA:P08066" /db_xref="InterPro:IPR004489" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR025192" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG10353" /db_xref="UniProtKB/Swiss-Prot:P08066" /translation="MSEQKTIRFIITRQDTADSTPYDEEFEIPYRPNLNVISALMEIR RNPVNVKGEKTTPVTWDMNCLEEVCGACSMVINGKPRQSCTALIDQLEQPIRLKPMKT FPVVRDLQVDRSRMFDSLKKVKAWIPIDGTYDLGPGPRMPEKRRQWAYELSKCMTCGV CLEACPNVNSKSKFMGPAPMSQVRLFNAHPTGAMNKSERLEALMDEGGLADCGNSQNC VQSCPKGIPLTTSIAALNRDTNLQAFRNFFGSDRV*" /label="sdhB CDS" gene complement(2402343..2403104) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /label="sdhB gene" downshifts complement(2402351) /Source="Nicolas_upshifts" /id="D1455" /incds=0 /nref=61 /ntot=257 /MaxReadThrough="5.46426" /MaxDrop="4.6864" /score="20.9204638" /energy="-10.8" /TU="U2202" /idTUdmin="U2205" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2403107..2404867) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 18535631, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 18535631, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (flavoprotein subunit)" /protein_id="NP_390722.2" /db_xref="EnsemblGenomes-Gn:BSU28440" /db_xref="EnsemblGenomes-Tr:CAB14804" /db_xref="GOA:P08065" /db_xref="InterPro:IPR003952" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR011280" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10352" /db_xref="UniProtKB/Swiss-Prot:P08065" /translation="MSQSSIIVVGGGLAGLMATIKAAESGMAVKLFSIVPVKRSHSVC AQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQPPVKAMCEAAPSIIHLLDRMGVM FNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEF LGAVLDDDRTCRGIVAQNLTNMQIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAAS IVYQQGAYYANGEFIQIHPTAIPGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKY PAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDPKELDIKLGGIIEIYEK FMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGGNRLGANSL LSAIYGGMVAGPNAVKYVNGLESSAEDMSSSLFDAHVKKEEEKWADIMSMDGTENAYV LHKELGEWMTANVTVVRHNDKLLKTDDKIQELMERFKKININDTTKWSNQGAMFTRQF SNMLQLARVITLGAYNRNESRGAHYKPDYPERNDDEWLKTTMAKHVSPYEAPEFEYQD VDVSLITPRKRDYSKKKVAK*" /label="sdhA CDS" gene complement(2403107..2404867) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /label="sdhA gene" CDS complement(2404901..2405509) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /EC_number="1.3.5.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (cytochrome b558 subunit)" /protein_id="NP_390723.1" /db_xref="EnsemblGenomes-Gn:BSU28450" /db_xref="EnsemblGenomes-Tr:CAB14805" /db_xref="GOA:P08064" /db_xref="InterPro:IPR000701" /db_xref="InterPro:IPR011138" /db_xref="InterPro:IPR016002" /db_xref="InterPro:IPR034804" /db_xref="SubtiList:BG10351" /db_xref="UniProtKB/Swiss-Prot:P08064" /translation="MSGNREFYFRRLHSLLGVIPVGIFLIQHLVVNQFAARGAEAFNS AAHFMDSLPFRYALEIFIIFLPLIYHAVYGVYIAFTAKNNAGQYSYMRNWLFVLQRVT GIITLIFVSWHVWETRIAAQMGAEVNFDMMANILSSPAMLGFYIVGVLSTIFHFSNGL WSFAVTWGITVTPRSQRISTYVTLIIFVALSYVGLKAIFAFV*" /label="sdhC CDS" gene complement(2404901..2405509) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /label="sdhC gene" promotor_-35 2405279..2405286 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2405299..2405318 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2405301 /Source="Nicolas_upshifts" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2405510..2405605) /Source="Nicolas_S_feature" /locus_tag="new_2908738_2908833_c" /HighExp="Lbtran, dia5, Mt0, T0.30H, T1.0H, M0t90, M40t90, T0.0H, Glucon, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.78844099999999995" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1076" promotor_-10 complement(2405595..2405614) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-10" upshifts complement(2405605) /Source="Nicolas_upshifts" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="upshifts" S_feature complement(2405607..2406228) /Source="Nicolas_S_feature" /locus_tag="new_2908835_2909456_c" /HighExp="MG 120, B36, UNK1, Fru, MG 150, BMM, Gly, Glucon, Glu, GM-0.1" /AntisenseName="yslB" /AntisenseCor="-0.44143968421748903" /AntisenseRegPval="-13.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1077" promotor_-35 complement(2405629..2405636) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-35" promotor_-35 2405744..2405748 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2405758..2405858 /Source="Nicolas_upshift_promotors" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2405765..2405784 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2405774 /Source="Nicolas_upshifts" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" CDS 2405802..2406248 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390724.1" /db_xref="EnsemblGenomes-Gn:BSU28460" /db_xref="EnsemblGenomes-Tr:CAB14806" /db_xref="InterPro:IPR019642" /db_xref="InterPro:IPR024096" /db_xref="PDB:3NJC" /db_xref="SubtiList:BG11236" /db_xref="UniProtKB/Swiss-Prot:P42955" /translation="MKSKFEASIDNLKEIEMNAYAYELIREIVLPDMLGQDYSSMMYW AGKHLARKFPLESWEEFPAFFEEAGWGTLTNVSAKKQELEFELEGPIISNRLKHQKEP CFQLEAGFIAEQIQLMNDQIAESYEQVKKRADKVVLTVKWDMKDPV*" /label="yslB CDS" gene 2405802..2406248 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /label="yslB gene" upshifts 2405818 /Source="Nicolas_upshifts" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" downshifts 2406236 /Source="Nicolas_upshifts" /id="D1456" /incds=0 /nref=217 /ntot=255 /MaxReadThrough="2.21897" /MaxDrop="6.5759" /score="4.74486914" /energy="-10.8" /TU="NA" /idTUdmin="U2203" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2406274) /Source="Nicolas_upshifts" /id="D1457" /incds=0 /nref=8 /ntot=160 /MaxReadThrough="5.89867" /MaxDrop="4.19639" /score="2.38159916" /energy="-10.8" /TU="U2205" /idTUdmin="U2206" /TUdmin=1270 /isTUend="FALSE" /label="downshifts" CDS complement(2406292..2407518) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2981221, 2981222, 14597663, 1980002, 8757727, 9851048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2981221, 2981222, 14597663, 1980002, 8757727, 9851048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II alpha subunit (aa 1->408)" /protein_id="NP_390725.1" /db_xref="EnsemblGenomes-Gn:BSU28470" /db_xref="EnsemblGenomes-Tr:CAB14807" /db_xref="GOA:P08495" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10350" /db_xref="UniProtKB/Swiss-Prot:P08495" /translation="MGLIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMG KSTDELVSLAKAISDQPSKREMDMLLATGEQVTISLLSMALQEKGYDAVSYTGWQAGI RTEAIHGNARITDIDTSVLADQLEKGKIVIVAGFQGMTEDCEITTLGRGGSDTTAVAL AAALKADKCDIYTDVPGVFTTDPRYVKSARKLEGISYDEMLELANLGAGVLHPRAVEF AKNYQVPLEVRSSTETEAGTLIEEESSMEQNLIVRGIAFEDQITRVTIYGLTSGLTTL STIFTTLAKRNINVDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIET ESKLAKVSIVGSGMVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAV ESLHDAFELSKHPSAV*" /label="lysCA CDS" CDS complement(2406292..2406783) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1980002, 2981221, 2981222, 8757727, 9851048, 14597663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1980002, 2981221, 2981222, 8757727, 9851048, 14597663; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II beta subunit (aa 246->408)" /protein_id="YP_009513994.1" /translation="MEQNLIVRGIAFEDQITRVTIYGLTSGLTTLSTIFTTLAKRNIN VDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIETESKLAKVSIVGSG MVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAVESLHDAFELSKHP SAV*" /label="lysCB CDS" gene complement(2406292..2407518) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /label="lysCA gene" gene complement(2406292..2406783) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /label="lysCB gene" downshifts complement(2407632) /Source="Nicolas_upshifts" /id="D1458" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="7.23315" /MaxDrop="4.15833" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=44 /isTUend="FALSE" /label="downshifts" misc_RNA complement(2407644..2407823) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:14523230, 14597663, 14627808, 21169337, 22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523230, 14597663, 14627808, 21169337, 22416067; Product type n: RNA" /label="kswC RNA" gene complement(2407644..2407823) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /label="kswC gene" downshifts complement(2407676) /Source="Nicolas_upshifts" /id="D1459" /incds=0 /nref=22 /ntot=132 /MaxReadThrough="7.09997" /MaxDrop="4.61976" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2407848..2407867) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-10" upshifts complement(2407855) /Source="Nicolas_upshifts" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="upshifts" promotor_-35 complement(2407880..2407887) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-35" CDS complement(2407888..2409660) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /EC_number="4.1.99.3" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8655545, 16267290, 16426634, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655545, 16267290, 16426634, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit C)" /protein_id="NP_390727.2" /db_xref="EnsemblGenomes-Gn:BSU28490" /db_xref="EnsemblGenomes-Tr:CAB14809" /db_xref="GOA:P14951" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR001162" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004791" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR035901" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10349" /db_xref="UniProtKB/Swiss-Prot:P14951" /translation="MNKQLKEKLALLPDQPGCYLMKDRQQTVIYVGKAKVLKNRVRSY FTGSHDAKTQRLVTEIEDFEYIVTSSNLEALILEMNLIKKHDPKYNVMLKDDKTYPFI KLTHERHPRLIVTRNVKKDKGRYFGPYPNVQAARETKKLLDRLYPLRKCSKLPDRVCL YYHLGQCLAPCVKDISEETNRELVESITRFLRGGYNEVKKELEEKMHEAAENLEFERA KELRDQIAHIESTMEKQKMTMNDLVDRDVFAYAYDKGWMCVQVFFIRQGKLIERDVSM FPLYQEADEEFLTFIGQFYSKNNHFLPKEILVPDSIDQSMIEQLLETNVHQPKKGPKK ELLMLAHKNAKIALKEKFSLIERDEERSIGAVQKLGEALNIYTPHRIEAFDNSNIQGT NPVSAMIVFIDGKPYKKEYRKYKIKTVTGPDDYGSMREVVRRRYTRVLRENLPLPDLI IIDGGKGQINAARDVIENELGLDIPIAGLAKDEKHRTSNLLIGDPLEVAYLERNSQEF YLLQRIQDEVHRFAISFHRQIRGKSAFQSVLDDIPGIGEKRKKMLLKHFGSVKKMKEA SLEDIKKAGVPAAAAQLLYDKLQK*" /label="uvrC CDS" gene complement(2407888..2409660) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /label="uvrC gene" promotor_-10 complement(2409687..2409706) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-10" upshifts complement(2409701) /Source="Nicolas_upshifts" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="upshifts" promotor_-35 complement(2409720..2409727) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-35" downshifts complement(2409790) /Source="Nicolas_upshifts" /id="D1460" /incds=0 /nref=237 /ntot=268 /MaxReadThrough="4.77689" /MaxDrop="6.41061" /score="23.4086154" /energy="-10.5" /TU="U2207,U2208" /idTUdmin="U2209" /TUdmin=373 /isTUend="FALSE" /label="downshifts" CDS complement(2409796..2410110) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268; Product type c: carrier" /codon_start=1 /transl_table=11 /product="thioredoxin" /protein_id="NP_390728.1" /db_xref="EnsemblGenomes-Gn:BSU28500" /db_xref="EnsemblGenomes-Tr:CAB14810" /db_xref="GOA:P14949" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:2GZY" /db_xref="PDB:2GZZ" /db_xref="PDB:2IPA" /db_xref="PDB:2VOC" /db_xref="SubtiList:BG10348" /db_xref="UniProtKB/Swiss-Prot:P14949" /translation="MAIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQ EMGDKLKIVKIDVDENQETAGKYGVMSIPTLLVLKDGEVVETSVGFKPKEALQELVNK HL*" /label="trxA CDS" gene complement(2409796..2410110) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /label="trxA gene" promotor_-10 complement(2410136..2410155) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2410150) /Source="Nicolas_upshifts" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2410152..2410361) /Source="Nicolas_S_feature" /locus_tag="new_2913380_2913589_c" /HighExp="Etha, Salt, Gly, Sw, M9-stat, LPhT, BC, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984399999999996" /TUshortSig="SigB, SigA" /TUshortPSig="0.991, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1078" promotor_-35 complement(2410171..2410173) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2410255..2410365) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="CDS C-terminal fragment" /db_xref="PSEUDO:SOX90589.1" /translation="MVKYMTVKRRCDLMLRTILMIIGAIVVIGAIIRFVF*" /label="CDS C-terminal fragment" gene complement(2410255..2410365) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /pseudo /label="gene" promotor_-10 complement(2410351..2410369) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-10" upshifts complement(2410361) /Source="Nicolas_upshifts" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="upshifts" promotor_-35 complement(2410384..2410390) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-35" CDS complement(2410433..2411920) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 17827291, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 17827291, 18757805; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exo-alpha-L-arabinofuranosidase" /protein_id="NP_390729.2" /db_xref="EnsemblGenomes-Gn:BSU28510" /db_xref="EnsemblGenomes-Tr:CAB14811" /db_xref="GOA:P94552" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11985" /db_xref="UniProtKB/Swiss-Prot:P94552" /translation="MSEHQAVIQTDIAKGTINKNIYGHFAEHLGRGIYEGIWVGTDSD IPNINGIRKDVLEALKQLHIPVLRWPGGCFADEYHWANGVGDRKTMLNTHWGGTIESN EFGTHEFMMLCELLECEPYICGNVGSGTVQEMSEWIEYMTFEEGTPMSDWRKQNGREE PWKLKYFGVGNENWGCGGNMHPEYYADLYRRFQTYVRNYSGNDIYKIAGGANVDDFNW TDVLMKKAAGLMDGLSLHYYTIPGDFWKGKGSATEFTEDEWFITMKKAKYIDELIQKH GTIMDRYDPEQRVGLIIDEWGTWFDPEPGTNPGFLYQQNTIRDALVAASHFHIFHQHC RRVQMANIAQTVNVLQAMILTEGERMLLTPTYHVFNMFKVHQDASLLATETMSADYEW NGETLPQISISASKQAEGDINITICNIDHQNKAEAEIELRGLHKAADHSGVILTAEKM NAHNTFDDPHHVKPESFRQYTLSKNKLKVKLPPMSVVLLTLRADS*" /label="abfB CDS" gene complement(2410433..2411920) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /label="abfB gene" S_feature complement(2411921..2412033) /Source="Nicolas_S_feature" /locus_tag="new_2915149_2915261_c" /HighExp="T0.30H, M40t90, M0t90, BC, M9-stat, T1.30H, T1.0H, T2.0H, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1079" promotor_-10 complement(2412014..2412033) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-10" upshifts complement(2412033) /Source="Nicolas_upshifts" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="upshifts" promotor_-35 complement(2412048..2412055) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-35" CDS complement(2412137..2413114) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 20059546, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 20059546, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (alpha subunit)" /protein_id="NP_390730.1" /db_xref="EnsemblGenomes-Gn:BSU28520" /db_xref="EnsemblGenomes-Tr:CAB14812" /db_xref="GOA:P94551" /db_xref="InterPro:IPR001308" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR014731" /db_xref="InterPro:IPR018206" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR033947" /db_xref="SubtiList:BG11934" /db_xref="UniProtKB/Swiss-Prot:P94551" /translation="MGKKVIVLGEIRDGELRNVTFEAIAAGRTISGDGEVIGVLIGEN VQSIAQELIHYGADKVLTAEDPKLKTYTADGYSQVMRGVIEQENPDSVIFGHTAMGKD LSPKLAARLQTGLISDAIDVSVTGGNVVFTRPIYSGKAFERVISTDPMIFATIRPNNI QASEKDTSRSGSIESIDVSLTDLRTVIQEVVKKTADGVDLSEAKIIVAGGRGVKSKEG FQPLQELAEVLGAAVGASRGACDADYCDYALQIGQTGKVVTPDLYIACGISGAIQHLA GMSNSKVIVAINKDPEADIFKIADYGIVGDLFEVVPLLTEEFKQLNIHS*" /label="etfA CDS" gene complement(2412137..2413114) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /label="etfA gene" downshifts complement(2412145) /Source="Nicolas_upshifts" /id="D1461" /incds=0 /nref=58 /ntot=179 /MaxReadThrough="2.43782" /MaxDrop="7.95053" /score="30.2462458" /energy="-13.5" /TU="NA" /idTUdmin="U2210" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2413150..2413923) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10026281, 17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10026281, 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (beta subunit)" /protein_id="NP_390731.1" /db_xref="EnsemblGenomes-Gn:BSU28530" /db_xref="EnsemblGenomes-Tr:CAB14813" /db_xref="GOA:P94550" /db_xref="InterPro:IPR000049" /db_xref="InterPro:IPR012255" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR033948" /db_xref="SubtiList:BG11935" /db_xref="UniProtKB/Swiss-Prot:P94550" /translation="MNLFVLMKRTFDTEEKIVIETGKIQDDGAEWIINPYDEYAIEEA IQLKEKHGGTITAVTVGGEEAEKELRTALAMGCDQAVLINIEDDLDEPDQYSISQVLY HYMKDQEFDLILGGNVAIDGGSGQVAPRLAELLDIPCITTITKLEINGTDAEAERDVE GDVEKIKTTLPLLVTAQQGLNEPRYPSLPGIMKAKKKPLEELELDDLDLDEEDAEPKL KTIERFLPPKKEAGKLLQGEPAEQAKELVSLLRSEAKVI*" /label="etfB CDS" gene complement(2413150..2413923) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /label="etfB gene" CDS complement(2413938..2414714) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-CoA hydratase" /protein_id="NP_390732.1" /db_xref="EnsemblGenomes-Gn:BSU28540" /db_xref="EnsemblGenomes-Tr:CAB14814" /db_xref="GOA:P94549" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12331" /db_xref="UniProtKB/Swiss-Prot:P94549" /translation="MNAISLAVDQFVAVLTIHNPPANALSSRILEELSSCLDQCETDA GVRSIIIHGEGRFFSAGADIKEFTSLKGNEDSSLLAERGQQLMERIESFPKPIIAAIH GAALGGGLELAMACHIRIAAEDAKLGLPELNLGIIPGFAGTQRLPRYVGTAKALELIG SGEPISGKEALDLGLVSIGAKDEAEVIEKAKALAAKFAEKSPQTLASLLELLYSNKVY SYEGSLKLEAKRFGEAFESEDAKEGIQAFLEKRKPQFKGE*" /label="fadB CDS" gene complement(2413938..2414714) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /label="fadB gene" downshifts 2414003 /Source="Nicolas_upshifts" /id="D1462" /incds=1 /nref=1 /ntot=21 /MaxReadThrough="0.92259" /MaxDrop="4.42725" /score="-8.29305955" /energy="-5.1" /TU="NA" /idTUdmin="U2203" /TUdmin=7767 /isTUend="FALSE" /label="downshifts" CDS complement(2414729..2415313) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17189250, 18941141, 21398533, 24356978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 18941141, 21398533, 24356978; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of fatty acids degradation [FadR-long-chain (C14-C20) acyl-CoAs]" /protein_id="NP_390733.1" /db_xref="EnsemblGenomes-Gn:BSU28550" /db_xref="EnsemblGenomes-Tr:CAB14815" /db_xref="GOA:P94548" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013570" /db_xref="InterPro:IPR036271" /db_xref="PDB:1VI0" /db_xref="PDB:3WHB" /db_xref="PDB:3WHC" /db_xref="SubtiList:BG12330" /db_xref="UniProtKB/Swiss-Prot:P94548" /translation="MKQKRPKYMQIIDAAVEVIAENGYHQSQVSKIAKQAGVADGTIY LYFKNKEDILISLFKEKMGQFIERMEEDIKEKATAKEKLALVISKHFSLLAGDHNLAI VTQLELRQSNLELRQKINEILKGYLNILDGILTEGIQSGEIKEGLDVRLARQMIFGTI DETVTTWVMNDQKYDLVALSNSVLELLVSGIHNK*" /label="fadR CDS" gene complement(2414729..2415313) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /label="fadR gene" promotor_-10 complement(2415355..2415374) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2415355) /Source="Nicolas_upshifts" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2415387..2415394) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2415418..2417100) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17085570, 17189250, 21398533, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17085570, 17189250, 21398533, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long chain acyl-CoA ligase (degradative)" /protein_id="NP_390734.1" /db_xref="EnsemblGenomes-Gn:BSU28560" /db_xref="EnsemblGenomes-Tr:CAB14816" /db_xref="GOA:P94547" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG11946" /db_xref="UniProtKB/Swiss-Prot:P94547" /translation="MQSQKPWLAEYPNDIPHELPLPNKTLQSILTDSAARFPDKTAIS FYGKKLTFHDILTDALKLAAFLQCNGLQKGDRVAVMLPNCPQTVISYYGVLFAGGIVV QTNPLYTEHELEYQLRDAQVSVIITLDLLFPKAIKMKTLSIVDQILITSVKDYLPFPK NILYPLTQKQKVHIDFDKTANIHTFASCMKQEKTELLTIPKIDPEHDIAVLQYTGGTT GAPKGVMLTHQNILANTEMCAAWMYDVKEGAEKVLGIVPFFHVYGLTAVMNYSIKLGF EMILLPKFDPLETLKIIDKHKPTLFPGAPTIYIGLLHHPELQHYDLSSIKSCLSGSAA LPVEVKQKFEKVTGGKLVEGYGLSEASPVTHANFIWGKNKPGSIGCPWPSTDAAIYSE ETGELAAPYEHGEIIVKGPQVMKGYWNKPEETAAVLRDGWLFTGDMGYMDEEGFFYIA DRKKDIIIAGGYNIYPREVEEALYEHEAIQEIVVAGVPDSYRGETVKAFVVLKKGAKA DTEELDAFARSRLAPYKVPKAYEFRKELPKTAVGKILRRRLLEEETENHHIK*" /label="lcfA CDS" gene complement(2415418..2417100) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /label="lcfA gene" misc_feature complement(2417129..2417148) /Source="Nicolas_upshift_promotors" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2417137) /Source="Nicolas_upshifts" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2417225) /Source="Nicolas_upshifts" /id="D1463" /incds=0 /nref=8 /ntot=101 /MaxReadThrough="2.17789" /MaxDrop="3.3655" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2417289..2417693) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390735.1" /db_xref="EnsemblGenomes-Gn:BSU28570" /db_xref="EnsemblGenomes-Tr:CAB14817" /db_xref="GOA:P94546" /db_xref="InterPro:IPR007140" /db_xref="SubtiList:BG12329" /db_xref="UniProtKB/Swiss-Prot:P94546" /translation="MSDFWENELVEIAAYYSVAVLCLVLFLTVFELVTAYKNWEEIQK GNLAVAMATGGKILGIANVFQHSISQHNSLLQMIGWGVYGFVMLLISYFIFEFLTPRF KIDQEIENDNRAVGFISFVISVGLSFVVAAGI*" /label="yshE CDS" gene complement(2417289..2417693) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /label="yshE gene" downshifts complement(2417291) /Source="Nicolas_upshifts" /id="D1464" /incds=0 /nref=1 /ntot=75 /MaxReadThrough="3.74343" /MaxDrop="2.92029" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2417708..2420065) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11254128, 12719520, 22333191, 27799325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254128, 12719520, 22333191, 27799325; Product type f: factor" /codon_start=1 /transl_table=11 /product="homologous recombination factor" /protein_id="NP_390736.1" /db_xref="EnsemblGenomes-Gn:BSU28580" /db_xref="EnsemblGenomes-Tr:CAB14818" /db_xref="GOA:P94545" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR002625" /db_xref="InterPro:IPR005747" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036063" /db_xref="InterPro:IPR036187" /db_xref="SubtiList:BG12328" /db_xref="UniProtKB/Swiss-Prot:P94545" /translation="MQQKVLSALEFHKVKEQVIGHAASSLGKEMLLELKPSASIDEIK KQLDEVDEASDIIRLRGQAPFGGLVDIRGALRRAEIGSVLSPSEFTEISGLLYAVKQM KHFITQMAEDGVDIPLIHQHAEQLITLSDLERDINSCIDDHGEVLDHASETLRGIRTQ LRTLESRVRDRLESMLRSSSASKMLSDTIVTIRNDRFVIPVKQEYRSSYGGIVHDTSS SGATLFIEPQAIVDMNNSLQQAKVKEKQEIERILRVLTEKTAEYTEELFLDLQVLQTL DFIFAKARYAKAVKATKPIMNDTGFIRLKKARHPLLPPDQVVANDIELGRDFSTIVIT GPNTGGKTVTLKTLGLLTLMAQSGLHIPADEGSEAAVFEHVFADIGDEQSIEQSLSTF SSHMVNIVGILEQVNENSLVLFDELGAGTDPQEGAALAMSILDDVHRTNARVLATTHY PELKAYGYNREGVMNASVEFDIETLSPTYKLLIGVPGRSNAFEISKRLGLPDHIIGQA KSEMTAEHNEVDTMIASLEQSKKRAEEELSETESIRKEAEKLHKELQQQIIELNSKKD KMLEEAEQQAAEKVKAAMKEAEDIIHELRTIKEEHKSFKDHELINAKKRLEGAMPAFE KSKKPEKPKTQKRDFKPGDEVKVLTFGQKGTLLEKTGGNEWNVQIGILKMKVKEKDLE FIKSAPEPKKEKMITAVKGKDYHVSLELDLRGERYENALSRVEKYLDDAVLAGYPRVS IIHGKGTGALRKGVQDLLKNHRSVKSSRFGEAGEGGSGVTVVELK*" /label="mutSB CDS" gene complement(2417708..2420065) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /label="mutSB gene" CDS complement(2420086..2421798) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /EC_number="2.7.7.7" /EC_number="3.1.11.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:18776221, 18938175, 28254425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18776221, 18938175, 28254425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase/3'-5' exonuclease X" /protein_id="NP_390737.1" /db_xref="EnsemblGenomes-Gn:BSU28590" /db_xref="EnsemblGenomes-Tr:CAB14819" /db_xref="GOA:P94544" /db_xref="InterPro:IPR002054" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010996" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR022311" /db_xref="InterPro:IPR027421" /db_xref="InterPro:IPR029398" /db_xref="InterPro:IPR037160" /db_xref="SubtiList:BG12327" /db_xref="UniProtKB/Swiss-Prot:P94544" /translation="MHKKDIIRLLETIAVYMELKGDNPFKVSAFRKAAAALEQDDRSL SEMDDMMSLSGIGKGTYSVIKEYIDEGKSSTLESLQKEVPEGLVPLLKLPGLGGKKIA KLYKELGVHDAESLKEACEQQKVQGLAGFGKKSEEKILQALGEAGKQPERFPIGYALR IAREIEEHLSQFTHIIKFSRAGSLRRARETVKDLDYIIATDHPAEVREQLLELPNIKS VIASGDTKVSVILSFEYETSVDFRLVTEEQFPTTLHHFTGSKDHNIKMRQIAKERGER ISEYGVETVETGEIKTFPSEREFYAHFGLPLIPPEIRESGQEVETYSDSIELIELGQI KGDLHMHSTWSDGAFSIREMAEACIKKGYQYMAITDHSQYLKVANGLTAERLKQQAKE IDALNAEFENFRILKGVEMDILPDGTLDYDDDVLAEMDIVIASIHSSFNQPEHVIMKR LETALTNKHVDIIAHPTGRLIGRRAGYEIDIDQLIELARKTNTALELNANPARLDLRT EHLMKANEQGVTLVINTDAHNIEMLDDMKTGVTAARKGWTETKNVLNARSLKDVEAFL KRND*" /label="polX CDS" gene complement(2420086..2421798) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /label="polX gene" S_feature complement(2421799..2421871) /Source="Nicolas_S_feature" /locus_tag="new_2925027_2925099_c" /HighExp="Cold, LPhT, LBGstat, H2O2, dia15, G180, G135, Sw, G150, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1080" CDS complement(2421872..2422405) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390738.1" /db_xref="EnsemblGenomes-Gn:BSU28600" /db_xref="EnsemblGenomes-Tr:CAB14820" /db_xref="GOA:P94543" /db_xref="InterPro:IPR003825" /db_xref="SubtiList:BG12326" /db_xref="UniProtKB/Swiss-Prot:P94543" /translation="MLDIIILILLLMGTLLGLKRGFILQFIRLTSFILSIAFAALFYK NVAPHLHWIPAPDFSAGQPALSFFTGNLEAAYYNAIAFIVLFIIAKILLRIIGSFLSI VAGIPVIKQINQMLGAVLGFLEVYLFTFVLLYVASVLPVDALQQMMGQSSLANVIINH TPYLSGLLQELWTQYGA*" /label="yshB CDS" gene complement(2421872..2422405) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /label="yshB gene" CDS complement(2422412..2422669) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /experiment="publication(s) with functional evidences, PMID:15317782, 16796675, 18588879, 20711458, 24097947, 26258635" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317782, 16796675, 18588879, 20711458, 24097947, 26258635; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of cell division" /protein_id="NP_390739.1" /db_xref="EnsemblGenomes-Gn:BSU28610" /db_xref="EnsemblGenomes-Tr:CAB14821" /db_xref="GOA:P94542" /db_xref="InterPro:IPR007838" /db_xref="InterPro:IPR023688" /db_xref="InterPro:IPR036192" /db_xref="SubtiList:BG12325" /db_xref="UniProtKB/Swiss-Prot:P94542" /translation="MSDGKKTKTTVDIYGQHFTIVGEESRAHMRYVAGIVDDKMREIN EKNPYLDINKLAVLTAVNVVHDYVKLQEKCEKLERQLKEKD*" /label="zapA CDS" gene complement(2422412..2422669) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /label="zapA gene" promotor_-10 complement(2422696..2422715) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2422712) /Source="Nicolas_upshifts" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2422727..2422734) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2422752..2422771 /Source="Nicolas_upshift_promotors" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2422759 /Source="Nicolas_upshifts" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="upshifts" CDS 2422803..2423744 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /EC_number="3.1.26.4" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9888800, 10094689, 12794188, 23882084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888800, 10094689, 12794188, 23882084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HIII" /protein_id="NP_390740.1" /db_xref="EnsemblGenomes-Gn:BSU28620" /db_xref="EnsemblGenomes-Tr:CAB14822" /db_xref="GOA:P94541" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR004641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR024568" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12324" /db_xref="UniProtKB/Swiss-Prot:P94541" /translation="MSHSVIKVSLSAIDQMKMTYSGSLTASVPQGAVFQAKPPGCTIT AYQSGKVLFQGKNAAAESARWGTAEPQEKKKTAKKPADPRYAPPADIAGMSVIGSDEV GTGDYFGPMTVVCAYVDKTMLPLMKELGVKDSKDLKDPQIIEIARNLIKTIPYSLLVL KNEKYNSMQEKGMSQGKMKALLHNQAITHLLRKLDGVKPEAILIDQFAEPGVYFNHLK GRDIVKERTYFSTKAEGIHLAVAAASIIARYSFLMEMDKLSRAAGMTLPKGAGPHVDE AAAKLILKKGASALRTFTKLHFANTQKAQRLADKKRS*" /label="rnhC CDS" gene 2422803..2423744 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /label="rnhC gene" promotor_-10 complement(2423476..2423495) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2423491) /Source="Nicolas_upshifts" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2423509..2423516) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2423727 /Source="Nicolas_upshifts" /id="D1465" /incds=0 /nref=150 /ntot=232 /MaxReadThrough="1.71535" /MaxDrop="5.25365" /score="25.6336933" /energy="-13.7" /TU="NA" /idTUdmin="U2213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2423759) /Source="Nicolas_upshifts" /id="D1466" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.4685" /MaxDrop="5.29665" /score="-4.45611985" /energy="-14.9" /TU="NA" /idTUdmin="U2216" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(2423780..2426194) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (beta subunit)" /protein_id="NP_390741.1" /db_xref="EnsemblGenomes-Gn:BSU28630" /db_xref="EnsemblGenomes-Tr:CAB14823" /db_xref="GOA:P17922" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004532" /db_xref="InterPro:IPR005121" /db_xref="InterPro:IPR005146" /db_xref="InterPro:IPR005147" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020825" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR036690" /db_xref="SubtiList:BG10875" /db_xref="UniProtKB/Swiss-Prot:P17922" /translation="MFVSYKWLEDYVDLKGMDPAVLAEKITRAGIEVEGIEYKGEGIK GVVIGHVLEREQHPNADKLNKCLVDIGAEAPVQIICGAPNVDKGQKVAVATVGAVLPG NFKIKKAKLRGEESNGMICSLQELGIESKLVAKEYAEGIFVFPNDAETGSDALAALQL DDAILELGLTPNRADAMNMLGVAYEVAAILDTEVKLPQTDYPAASEQASDYISVKIED QEANPLYTAKIIKNVTIAPSPLWMQTKLMNAGIRPHNNVVDITNFVLLEYGQPLHAFD YDRFGSKEVVVRKAAENEMIVTLDDQERKLSADHLVITNGTKAQAVAGVMGGAESEVQ EDTKTILLEAAYFNGQKVRKASKDLGLRSESSVRFEKGIDPARVRLAAERAAQLIHLY AGGEVLAGTVEEDHLTIEANNIHVSADKVSSVLGLTISKEELISIYKRLGFTVGEADD LLVVTVPSRRGDITIEEDLIEEAARLYGYDNIPSTLPETAGTTGGLTPYQAKRRKVRR FLEGAGLSQAITYSLTNEKKATAFAIEKSLNTVLALPMSEERSILRHSLVPNLLDSVS YNLARQTDSVALYEVGSVFLTKEEDTKPVETERVAGAVTGLWRKQLWQGEKKPVDFFV VKGIVEGLLDKLNVLDSIEFVQSERKQLHPGRTANILLNGSLIGFIGQVHPSLEKELD IKETYVFELDLHALLAAETAPLVYTAIPKYPSVTRDIALVTDKTVTSGQLESVIKEAG GKLLKEVTVFDVYEGEHMEEGKKSVAFSLQYVNPEQTLTEEEVTKAHSKVLKALEDTY QAVLRG*" /label="pheT CDS" gene complement(2423780..2426194) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /label="pheT gene" downshifts complement(2423803) /Source="Nicolas_upshifts" /id="D1467" /incds=0 /nref=214 /ntot=255 /MaxReadThrough="3.98669" /MaxDrop="7.11892" /score="32.4736491" /energy="-14.7" /TU="NA" /idTUdmin="U2216" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2426210..2427244) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390742.1" /db_xref="EnsemblGenomes-Gn:BSU28640" /db_xref="EnsemblGenomes-Tr:CAB14824" /db_xref="GOA:P17921" /db_xref="InterPro:IPR002319" /db_xref="InterPro:IPR004188" /db_xref="InterPro:IPR004529" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR022911" /db_xref="SubtiList:BG10874" /db_xref="UniProtKB/Swiss-Prot:P17921" /translation="MEEKLKQLEQEALEQVEAASSLKVVNDIRVQYLGKKGPITEVLR GMGKLSAEERPKMGALANEVRERIANAIADKNEKLEEEEMKQKLAGQTIDVTLPGNPV AVGGRHPLTVVIEEIEDLFIGMGYTVEEGPEVETDYYNFESLNLPKEHPARDMQDSFY ITEETLMRTQTSPVQTRTMEKHEGKGPVKIICPGKVYRRDNDDATHSHQFMQIEGLVV DKNISMSDLKGTLELVAKKMFGQDREIRLRPSFFPFTEPSVEVDVTCFKCGGNGCSVC KGTGWIEILGAGMVHPNVLKMAGFDPKEYQGFAFGMGVERIAMLKYGIDDIRHFYTND VRFISQFKQA*" /label="pheS CDS" gene complement(2426210..2427244) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /label="pheS gene" S_feature complement(2427245..2427565) /Source="Nicolas_S_feature" /locus_tag="new_2930473_2930793_c" /HighExp="HPh, Cold, GM 15, GM 10, Sw, C30, G150, MG-0.2, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1081" CDS 2427326..2427532 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513995.1" /translation="MWPRYHPYFRQTDAVVSFIDITESDSGSPLRAVYAVPATTQEVK PISGCVKNALSQRHFLPGKQLIRN*" /label="hypothetical protein CDS" gene 2427326..2427532 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /label="gene" S_feature 2427555..2427819 /Source="Nicolas_S_feature" /locus_tag="new_2930783_2931047" /HighExp="S8, S7, S6, BT, C30, B36, S5, Pyr, C90, Glucon" /AntisenseName="ysgA" /AntisenseCor="-0.23049778674462801" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.519" /TUlongSig="NA" /TUlongPSig="NA" /label="S1082" upshifts 2427555 /Source="Nicolas_upshifts" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2427560..2427579) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2427562..2427576 /Source="Nicolas_upshift_promotors" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2427565) /Source="Nicolas_upshifts" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2427594..2427597) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2427599..2428345) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 24809820, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal RNA methylase" /protein_id="NP_390743.1" /db_xref="EnsemblGenomes-Gn:BSU28650" /db_xref="EnsemblGenomes-Tr:CAB14825" /db_xref="GOA:P94538" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG12323" /db_xref="UniProtKB/Swiss-Prot:P94538" /translation="MKQIESAKNQKVKDWKKLHTKKERTKTNTFLIEGEHLVEEALKS PGIVKEILVKDETRIPSDLETGIQCYMLSEDAFSAVTETETPQQIAAVCHMPEEKLAT ARKVLLIDAVQDPGNLGTMIRTADAAGLDAVVLGDGTADAFNGKTLRSAQGSHFHIPV VRRNLPSYVDELKAEGVKVYGTALQNGAPYQEIPQSESFALIVGNEGAGVDAALLEKT DLNLYVPLYGQAESLNVAVAAAILVYHLRG*" /label="rlmBB CDS" gene complement(2427599..2428345) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /label="rlmBB gene" promotor_-10 complement(2428372..2428391) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-10" promotor_-35 2428378..2428384 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2428385) /Source="Nicolas_upshifts" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="upshifts" promotor_-10 2428398..2428409 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2428405..2428411) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-35" upshifts 2428412 /Source="Nicolas_upshifts" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2428464..2428679 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8171126, 10806362, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8171126, 10806362, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_390744.1" /db_xref="EnsemblGenomes-Gn:BSU28660" /db_xref="EnsemblGenomes-Tr:CAB14826" /db_xref="GOA:P94537" /db_xref="InterPro:IPR017525" /db_xref="SubtiList:BG12318" /db_xref="UniProtKB/Swiss-Prot:P94537" /translation="MDLNLRHAVIANVTGNNQEQLEHTIVDAIQSGEEKMLPGLGVLF EVIWQHASESEKNEMLKTLEGGLKPAE*" /label="sspI CDS" gene 2428464..2428679 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /label="sspI gene" S_feature complement(2428661..2430073) /Source="Nicolas_S_feature" /locus_tag="new_2931889_2933301_c" /HighExp="S6, S8, S7, BT, S5, C30, B36, S4, B60, C90" /AntisenseName="ysfB" /AntisenseCor="0.46970634471519201" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1083" promotor_-35 2428690..2428697 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2428713..2428732 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2428721 /Source="Nicolas_upshifts" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2428748..2429854 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (glycolate degradation operon)" /protein_id="NP_390745.2" /db_xref="EnsemblGenomes-Gn:BSU28670" /db_xref="EnsemblGenomes-Tr:CAB14827" /db_xref="InterPro:IPR008599" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12319" /db_xref="UniProtKB/Swiss-Prot:P94536" /translation="MFLQPLLAKKIIAEVKKMYEREVIIVNTDGLIMAGTNDERVGQF HEGALICAKERRSVIITKEDETRLKGVKAGINLPVFFDHDVIAVFGLTGEPAEIQPFG ELLRKMTELFIKESRHLEQSQWRERMLESFMIDWLQLKEWSPSFLEKAQLLGVDLSSR RQMILIQGYEWSPHDIEQMARSWKSSYPADLFIRWGNERILINHEVPQHEQRDRLLRK ILHICSFANTASSQYTAAGAGRAVASSSLTDSYEQAEKALAVSLKRKTPIFEEDLKLD MCLTEISPGTRNEFPQRVLGKALEHQELMNTIRTFFHHDLSLKQTAEDMHIHINTLRY RLAKAEQLTGLRFDRTEDVVTMYVALYFLDQDTK*" /label="ysfB CDS" gene 2428748..2429854 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /label="ysfB gene" promotor_-35 2429890..2429893 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2429909..2429928 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2429913 /Source="Nicolas_upshifts" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="upshifts" CDS 2429957..2431369 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase subunit" /protein_id="NP_390746.1" /db_xref="EnsemblGenomes-Gn:BSU28680" /db_xref="EnsemblGenomes-Tr:CAB14828" /db_xref="GOA:P94535" /db_xref="InterPro:IPR004113" /db_xref="InterPro:IPR004490" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR016171" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12320" /db_xref="UniProtKB/Swiss-Prot:P94535" /translation="MITKDVKEQLIQVSGPENFDDSNAGRLVYSYDATPQYQSMPDAV IAPRNTDEISRILTICSEHRVPIVPRGSGTNLCGGTCPTEGGLVLLFKHMNQILEIDE ENLTATVQPGVITLDMIRAVESKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVT RDYVIGLEVVLANGDIIRTGGKLAKDVAGYDLTRLFVGSEGTLGIVTEAIVKLVPKPE TKKTLLALYENIDAAAQTVSDIIAAKIIPATLEFLDQPTLLVIEDYAKIGLPTSAKAV LLIEQDGPFETVERDMEKIEAICKKGDAVSVQTAQTEEEAFALTEARRSALSALARLK PTTILEDATVPRSEIANMVKAINDIAAKYDISICTFGHAGDGNLHPTCTTDIRNKDEM ERVEQAFAEIFEKAIELGGTITGEHGVGEMKAPYLEMKLKKEGIDAMKALKAAFDPRN ILNPGKMFAKDARKRVVAER*" /label="glcD CDS" gene 2429957..2431369 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /label="glcD gene" promotor_-10 complement(2430059..2430078) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2430073) /Source="Nicolas_upshifts" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2430091..2430100) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2431366..2432700 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase (iron-sulfur subunit)" /protein_id="NP_390747.1" /db_xref="EnsemblGenomes-Gn:BSU28690" /db_xref="EnsemblGenomes-Tr:CAB14829" /db_xref="GOA:P94534" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012257" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="SubtiList:BG12321" /db_xref="UniProtKB/Swiss-Prot:P94534" /translation="MTTEKEMKQIQNEFKERMDEGELLNCMRCGFCLPSCPTYIESGF QETHSPRGRIALMKAVADGMIEPDEDVERSLSLCLGCRACEPVCPSGVKYGQLLEEAR DIIHQNKKHSLGERVMRKTAFHELFPHQNRMRSAVSLIGLYQRSGLQTAVRKSGMLRV LPEHLRTMEAVLPDVPKSKDMKHRPRFLPSIGPMKKRVAFFSGCLMDTMFLPTNNATL KLLQLAGCDIVIPPEQACCGALHGHSGEKNTGKELAKQNIAAFEALDVDAVITNAGGC GAFLTEYDHLLKDDPEWSERAAAFVQKLKDFSSVLVELDFHQMDLALETPQVVTYQDS CHLRNVMHTSLEPRQLLKSIKGAEFKEMEKADSCCGSAGIYNIVEVEMSMKILDSKMA AVKATEAILIVTANPGCLLQMKLGIEREGLSGKVRAVHLADLLLEAAGHKTS*" /label="glcF CDS" gene 2431366..2432700 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /label="glcF gene" Polymorphism join(2432399,2432401) /Source="geneious" /ID="SNP_BsDelta6_2935628_2935628" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=1035 /Change="C -> T" /Codon_Change="CTC -> CTT" /Coverage=142 /locus_tag="BSU_28690" /Protein_Effect="None" /Reference_Frequency="1.4%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=140 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 2432698 /Source="Nicolas_upshifts" /id="D1468" /incds=0 /nref=48 /ntot=148 /MaxReadThrough="3.07756" /MaxDrop="5.25031" /score="4.55188138" /energy="-14.3" /TU="U2220" /idTUdmin="U2220" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" downshifts complement(2432737) /Source="Nicolas_upshifts" /id="D1469" /incds=0 /nref=27 /ntot=221 /MaxReadThrough="1.51397" /MaxDrop="5.34865" /score="-5.71907967" /energy="-14.3" /TU="NA" /idTUdmin="U2222" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2432739..2432981) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390748.1" /db_xref="EnsemblGenomes-Gn:BSU28700" /db_xref="EnsemblGenomes-Tr:CAB14830" /db_xref="InterPro:IPR025870" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12322" /db_xref="UniProtKB/Swiss-Prot:P94533" /translation="MALNTRESARDITALDIPDTSASNTFEIGFVTENVEAVIKRMRE QGVSIIGEPKVKPWGQTVAYIADPDGHYIEICSPME*" /label="ysfE CDS" gene complement(2432739..2432981) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /label="ysfE gene" S_feature complement(2432982..2433153) /Source="Nicolas_S_feature" /locus_tag="new_2936210_2936381_c" /HighExp="Sw, M0t90, M40t90, M9-stat, T2.0H, BC, T0.30H, Lbstat, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1084" CDS complement(2433041..2433211) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513996.1" /translation="MGADVERSELKDGSIYTGLEGLLKMLRGVGNESINEISYSIRIG QQAGYSFFTGIF*" /label="hypothetical protein CDS" gene complement(2433041..2433211) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /label="gene" CDS complement(2433154..2434950) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 1848300, 17320232, 19682248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 1848300, 17320232, 19682248; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="carbon starvation-induced membrane protein" /protein_id="NP_390749.2" /db_xref="EnsemblGenomes-Gn:BSU28710" /db_xref="EnsemblGenomes-Tr:CAB14831" /db_xref="GOA:P94532" /db_xref="InterPro:IPR003706" /db_xref="InterPro:IPR025299" /db_xref="SubtiList:BG11924" /db_xref="UniProtKB/Swiss-Prot:P94532" /translation="MNAVTIVIASMCILAIAYRLYGTFMMVKVLKVNDDKPTPAHALE DGKDYVPTNKWVSFGHHFAAIAAAGPLVGPILAAQFGYLPGLLWLLIGAVIGGAVHDI VVLFASMRKNGKSLSEVAKDELGPVAGFCTGLSMLFIITITMAGLSMVVLHALERNPW GTFAVGITIPIAMGVGLFYKKTGNLKLASTVGFLFLMAGVFIGPWVQTTALGDFLTLD TKTLAIALPVYAFFAAALPVWLLLAPRDYLSSFMKIGVFIALIVGVFVVNPSIPFPAF TEFVKGGGPVLAGPVWPFISITIACGAISGFHAFVGSGTTPKMLNKWSDMKPVAFGAM LVECLVGIMALIAATALQPADYFAINSTPEVFRTLGMNVVHLPELSGEIGLDLEGRTG GAVTLAVGMTYIFTGMPFFSHLASYFFQFVIMFEAVFILTAIDAGTRVARYLIQDFFG EVYKPLKKTDWIPGSVFASALACLMWGYLLYSGDIGSIWALFGVSNQLMASVGLIIGA TIVLKIADKRRYILTCLIPLAYLYVTVNYAGYWMVRNVYLNPEAAGYSVLNGVLSIIM LVLGFIIIVAAVKKWAQMWKDPSLRMEASIPG*" /label="cstA CDS" gene complement(2433154..2434950) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /label="cstA gene" promotor_-10 complement(2433256..2433274) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2433274) /Source="Nicolas_upshifts" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2433286..2433294) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2434947 /Source="Nicolas_upshifts" /id="D1470" /incds=0 /nref=4 /ntot=49 /MaxReadThrough="0.92122" /MaxDrop="3.18629" /score="12.2066828" /energy="-15.2" /TU="NA" /idTUdmin="U2220" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2434975..2434994) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2434985) /Source="Nicolas_upshifts" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2435009..2435015) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2435045..2435101) /Source="Nicolas_S_feature" /locus_tag="new_2938273_2938329_c" /HighExp="BC, Sw, M40t90, T1.30H, M0t90, T1.0H, T0.30H, Lbstat, T2.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1085" downshifts complement(2435069) /Source="Nicolas_upshifts" /id="D1471" /incds=0 /nref=12 /ntot=40 /MaxReadThrough="0.655710000000001" /MaxDrop="5.03461" /score="9.68754272" /energy="-10.5" /TU="NA" /idTUdmin="U2224" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2435102..2436604) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12777810, 14973026, 16233670, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12777810, 14973026, 16233670, 18757805; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-L-arabinofuranosidase" /protein_id="NP_390750.2" /db_xref="EnsemblGenomes-Gn:BSU28720" /db_xref="EnsemblGenomes-Tr:CAB14832" /db_xref="GOA:P94531" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11900" /db_xref="UniProtKB/Swiss-Prot:P94531" /translation="MKKARMIVDKEYKIGEVDKRIYGSFIEHMGRAVYEGIYEPDHPE ADEDGFRKDVQSLIKELQVPIIRYPGGNFLSGYNWEDGVGPVENRPRRLDLAWQTTET NEVGTNEFLSWAKKVNTEVNMAVNLGTRGIDAARNLVEYCNHPKGSYWSDLRRSHGYE QPYGIKTWCLGNEMDGPWQIGHKTADEYGRLAAETAKVMKWVDPSIELVACGSSNSGM PTFIDWEAKVLEHTYEHVDYISLHTYYGNRDNNLPNYLARSMDLDHFIKSVAATCDYV KAKTRSKKTINLSLDEWNVWYHSNEADKKVEPWITARPILEDIYNFEDALLVGSLLIT MLQHADRVKIACLAQLVNVIAPIMTEKGGEAWRQPIFYPYMHASVYGRGESLKPLISS PKYDCSDFTDVPYVDAAVVYSEEEETLTIFAVNKAEDQMETEISLRGFESYQIAEHIV LEHQDIKATNQHNRKNVVPHSNGSSSVSENGLTAHFTPLSWNVIRLKKQS*" /label="abfA CDS" gene complement(2435102..2436604) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /label="abfA gene" downshifts complement(2436475) /Source="Nicolas_upshifts" /id="D1472" /incds=1 /nref=7 /ntot=15 /MaxReadThrough="3.81491" /MaxDrop="6.33773" /score="2.73497974" /energy="-14.2" /TU="U2224,U2225" /idTUdmin="U2224" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(2436579..2436679) /Source="Nicolas_upshift_promotors" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2436619) /Source="Nicolas_upshifts" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2436623..2437468) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390751.2" /db_xref="EnsemblGenomes-Gn:BSU28730" /db_xref="EnsemblGenomes-Tr:CAB14833" /db_xref="GOA:P94530" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11912" /db_xref="UniProtKB/Swiss-Prot:P94530" /translation="MLRHSPQFSVYRIALTLFFMMLSLLYLFPIFCLLLGSLKPSSEL LRVGLNLDIDPKVMSFDNYTFLFNGGSIYFKWFFNSLVLGLFTTVLTLFFSSMIGYGL AVYDFKGRNIIFVLVLIIMMVPLEVMMLPLFKLTVGLHLIDSYTGVILPFIVSPVAVF FFRQYALGLPRDLLDSARMDGCTEFGIFFRIMAPLMKPAFGAMIILQSLNSWNNFLWP LIVLRSKEMFTLPIGLSSLLSPYGNNYDMLISGSVFAILPVIIIFLFFQKYFISGLTV GGVKG*" /label="araQ CDS" gene complement(2436623..2437468) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /label="araQ gene" CDS complement(2437469..2438410) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390752.1" /db_xref="EnsemblGenomes-Gn:BSU28740" /db_xref="EnsemblGenomes-Tr:CAB14834" /db_xref="GOA:P94529" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11911" /db_xref="UniProtKB/Swiss-Prot:P94529" /translation="MKPVKTGTVHPVPSAAKQSGWRDLFYSKKAAPYLFTAPFVLSFL VFFLYPIISVFIMSFQRILPGEVSFVGLSNYTALNNPTFYTALWNTLEYTFWTLIVLI PVPLLLAIFLNSKLVKFRNIFKSALFIPALTSTIVAGIIFRLIFGEMETSLANSILLK LGFSPQNWMNNEHTGMFLMVLLASWRWMGINILYFLAGLQNVPKELYEAADIDGANTM KKFLHITLPFLKPVTVYVLTISIIGGFRMFEESYVLWQNNSPGNIGLTLVGYLYQQGL AYNEMGYGAAIGIVLLIVILVVSLISLKLSGSFKGEG*" /label="araP CDS" gene complement(2437469..2438410) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /label="araP gene" CDS complement(2438446..2439747) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="sugar-binding lipoprotein" /protein_id="NP_390753.2" /db_xref="EnsemblGenomes-Gn:BSU28750" /db_xref="EnsemblGenomes-Tr:CAB14835" /db_xref="GOA:P94528" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG11910" /db_xref="UniProtKB/Swiss-Prot:P94528" /translation="MKKMTVCFLVLMMLLTLVIAGCSAEKSSGKSGETELTFWTFNGL HEQFYVEMVKEWNKKYPDRKIKLNTVVYPYGQMHDNLSISLIAGEGVPDIADVELARF SNFLKGSDIPLADLTPLIEKDRDKFVEARLTLYSKNGKLYGLDTHVGTTVMFYNMDVM KKAGVNPDDIKTWDDYHKAGQKVRKVTGKPMGTVETNDSATFLSMISQQNSGYFDKNG KLILNNDTNVKTLQYLKDMINDKTMIPAPGGGHHSEEYYGFMNQGGAASVLMPIWYMG RFIDYMPDLKGKIAIRPLPAWKEGGDRSAGLGGTATVVPKQSKHVELAKEFLAFAKGS EEGNKKLWSVLGFDPLRWDVWSSKELKEKNKYTDYFQNGTGIFSVLLDIKDEINPIYL HEDFAKASDLVNRSVLFDALKSQQKTPKQALDRAAGELKQK*" /label="araN CDS" gene complement(2438446..2439747) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /label="araN gene" CDS complement(2439778..2440962) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /EC_number="1.1.1.261" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-1-phosphate dehydrogenase [NAD+] (catabolic)" /protein_id="NP_390754.1" /db_xref="EnsemblGenomes-Gn:BSU28760" /db_xref="EnsemblGenomes-Tr:CAB14836" /db_xref="GOA:P94527" /db_xref="InterPro:IPR023003" /db_xref="InterPro:IPR032837" /db_xref="SubtiList:BG11909" /db_xref="UniProtKB/Swiss-Prot:P94527" /translation="MNRIAADVQRAFENAGEKTLPIKVEEIVLGKQAADSLLDYVKRK NNQHIVLVCDANTHRIAGIDLENRLNQEGFQAECLIIPENEAGDVTADERSLIHVLIH TKQPTDVMIAVGSGTIHDIVRFAAFQRDLPFISYPTAPSVDGFTSAGAPIILYGTKTT IQTKAPSALFADLDLLKAAPQSMVAAGFGDMLGKITSLADWEISRHLAGEPYSPAGAK IVQEALAACIEHTEDIAMKTETGIRVLMESLLVSGLVMLALDHSRPASGGEHHISHWI EMELMEKKRPQILHGAKVGCAAVLLTDTYRKLAQDDGLNEFSPSRREAIQSAYQTLPR GEVLADWLRSAGGPAYFDEIGVGQDSVKNAFRHAHTLRDRCTGLRIINENKTLINHGL YE*" /label="egsA CDS" gene complement(2439778..2440962) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /label="egsA gene" CDS complement(2440959..2441777) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /EC_number="3.1.3.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 14973026, 21575135, 22720735, 25848029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 14973026, 21575135, 22720735, 25848029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycolytic and pentose phosphate intermediates phosphatase" /protein_id="NP_390755.1" /db_xref="EnsemblGenomes-Gn:BSU28770" /db_xref="EnsemblGenomes-Tr:CAB14837" /db_xref="GOA:P94526" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11908" /db_xref="UniProtKB/Swiss-Prot:P94526" /translation="MRIMASHDTPVSPAGILIDLDGTVFRGNELIEGAREAIKTLRRM GKKIVFLSNRGNISRAMCRKKLLGAGIETDVNDIVLSSSVTAAFLKKHYRFSKVWVLG EQGLVDELRLAGVQNASEPKEADWLVISLHETLTYDDLNQAFQAAAGGARIIATNKDR SFPNEDGNAIDVAGMIGAIETSAQAKTELVVGKPSWLMAEAACTAMGLSAHECMIIGD SIESDIAMGKLYGMKSALVLTGSAKQGEQRLYTPDYVLDSIKDVTKLAEEGILI*" /label="araL CDS" gene complement(2440959..2441777) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /label="araL gene" CDS complement(2441755..2442444) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /EC_number="5.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10417639, 11418559, 11732895, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulose-5-phosphate 4-epimerase" /protein_id="NP_390756.1" /db_xref="EnsemblGenomes-Gn:BSU28780" /db_xref="EnsemblGenomes-Tr:CAB14838" /db_xref="GOA:P94525" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR004661" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG11906" /db_xref="UniProtKB/Swiss-Prot:P94525" /translation="MLETLKKEVLAANLKLQEHQLVTFTWGNVSGIDREKERIVIKPS GVEYSDLTADDLVVLNLDGEVVEGSLKPSSDTPTHVYLYKAFPNIGGIVHTHSQWATS WAQSGRDIPPLGTTHADYFDSAIPCTREMYDEEIIHDYELNTGKVIAETFQHHNYEQV PGVLVNNHGPFCWGTDALNAIHNAVVLETVAEMAYHSIMLNKDVTPINTVLHEKHFYR KHGANAYYGQS*" /label="araD CDS" gene complement(2441755..2442444) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /label="araD gene" CDS complement(2442461..2444143) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /EC_number="2.7.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 173711, 4910050, 10417639, 11418559, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulokinase" /protein_id="NP_390757.1" /db_xref="EnsemblGenomes-Gn:BSU28790" /db_xref="EnsemblGenomes-Tr:CAB14839" /db_xref="GOA:P94524" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005929" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG11905" /db_xref="UniProtKB/Swiss-Prot:P94524" /translation="MAYTIGVDFGTLSGRAVLVHVQTGEELAAAVKEYRHAVIDTVLP KTGQKLPRDWALQHPADYLEVLETTIPSLLEQTGVDPKDIIGIGIDFTACTILPIDSS GQPLCMLPEYEEEPHSYVKLWKHHAAQKHADRLNQIAEEEGEAFLQRYGGKISSEWMI PKVMQIAEEAPHIYEAADRIIEAADWIVYQLCGSLKRSNCTAGYKAMWSEKAGYPSDD FFEKLNPSMKTITKDKLSGSIHSVGEKAGSLTEKMAKLTGLLPGTAVAVANVDAHVSV PAVGITEPGKMLMIMGTSTCHVLLGEEVHIVPGMCGVVDNGILPGYAGYEAGQSCVGD HFDWFVKTCVPPAYQEEAKEKNIGVHELLSEKANHQAPGESGLLALDWWNGNRSTLVD ADLTGMLLGMTLLTKPEEIYRALVEATAYGTRMIIETFKESGVPIEELFAAGGIAEKN PFVMQIYADVTNMDIKISGSPQAPALGSAIFGALAAGKEKGGYDDIKKAAANMGKLKD ITYTPNAENAAVYEKLYAEYKELVHYFGKENHVMKRLKTIKNLQFSSAAKKN*" /label="araB CDS" gene complement(2442461..2444143) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /label="araB gene" CDS complement(2444157..2445647) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /EC_number="5.3.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 10669396, 11418559, 14973026, 18263741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 10669396, 11418559, 14973026, 18263741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-arabinose isomerase" /protein_id="NP_390758.2" /db_xref="EnsemblGenomes-Gn:BSU28800" /db_xref="EnsemblGenomes-Tr:CAB14840" /db_xref="GOA:P94523" /db_xref="InterPro:IPR003762" /db_xref="InterPro:IPR004216" /db_xref="InterPro:IPR009015" /db_xref="InterPro:IPR024664" /db_xref="SubtiList:BG11904" /db_xref="UniProtKB/Swiss-Prot:P94523" /translation="MLQTKDYEFWFVTGSQHLYGEETLELVDQHAKSICEGLSGISSR YKITHKPVVTSPETIRELLREAEYSETCAGIITWMHTFSPAKMWIEGLSSYQKPLMHL HTQYNRDIPWGTIDMDFMNSNQSAHGDREYGYINSRMGLSRKVIAGYWDDEEVKKEMS QWMDTAAALNESRHIKVARFGDNMRHVAVTDGDKVGAHIQFGWQVDGYGIGDLVEVMD RITDDEVDTLYAEYDRLYVISEETKRDEAKVASIKEQAKIELGLTAFLEQGGYTAFTT SFEVLHGMKQLPGLAVQRLMEKGYGFAGEGDWKTAALVRMMKIMAKGKRTSFMEDYTY HFEPGNEMILGSHMLEVCPTVALDQPKIEVHSLSIGGKEDPARLVFNGISGSAIQASI VDIGGRFRLVLNEVNGQEIEKDMPNLPVARVLWKPEPSLKTAAEAWILAGGAHHTCLS YELTAEQMLDWAEMAGIESVLISRDTTIHKLKHELKWNEALYRLQK*" /label="araA CDS" gene complement(2444157..2445647) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /label="araA gene" promotor_-10 complement(2445740..2445759) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2445747) /Source="Nicolas_upshifts" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2445749..2445824) /Source="Nicolas_S_feature" /locus_tag="new_2948977_2949052_c" /HighExp="M9-stat, T1.30H, T2.0H, T2.30H, T3.0H, T4.0H, T3.30H, T1.0H, BC, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1086" promotor_-35 complement(2445774..2445781) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2445825..2446796) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 15556708, 17827291, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 15556708, 17827291, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan-endo-1,5-alpha-L-arabinase" /protein_id="NP_390759.2" /db_xref="EnsemblGenomes-Gn:BSU28810" /db_xref="EnsemblGenomes-Tr:CAB14841" /db_xref="GOA:P94522" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR016840" /db_xref="InterPro:IPR023296" /db_xref="PDB:1UV4" /db_xref="SubtiList:BG11901" /db_xref="UniProtKB/Swiss-Prot:P94522" /translation="MKKKKTWKRFLHFSSAALAAGLIFTSAAPAEAAFWGASNELLHD PTMIKEGSSWYALGTGLTEERGLRVLKSSDAKNWTVQKSIFTTPLSWWSNYVPNYGQN QWAPDIQYYNGKYWLYYSVSSFGSNTSAIGLASSTSISSGGWKDEGLVIRSTSSNNYN AIDPELTFDKDGNPWLAFGSFWSGIKLTKLDKSTMKPTGSLYSIAARPNNGGALEAPT LTYQNGYYYLMVSFDKCCDGVNSTYKIAYGRSKSITGPYLDKSGKSMLEGGGTILDSG NDQWKGPGGQDIVNGNILVRHAYDANDNGIPKLLINDLNWSSGWPSY*" /label="abnA CDS" gene complement(2445825..2446796) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /label="abnA gene" S_feature complement(2446797..2446925) /Source="Nicolas_S_feature" /locus_tag="new_2950025_2950153_c" /HighExp="M9-stat, BC, T2.0H, T2.30H, T3.0H, S8, T1.30H, T3.30H, M0t90, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1087" promotor_-10 complement(2446910..2446929) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-10" upshifts complement(2446925) /Source="Nicolas_upshifts" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2446944..2446947) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-35" CDS complement(2446993..2448078) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15375159, 16021622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fructose-lysine aminopeptidase" /protein_id="NP_390760.1" /db_xref="EnsemblGenomes-Gn:BSU28820" /db_xref="EnsemblGenomes-Tr:CAB14842" /db_xref="GOA:P94521" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="PDB:1VHE" /db_xref="SubtiList:BG12317" /db_xref="UniProtKB/Swiss-Prot:P94521" /translation="MAKLDETLTMLKDLTDAKGIPGNEREVRQVMKSYIEPFADEVTT DRLGSLIAKKTGAENGPKIMIAGHLDEVGFMVTQITDKGFIRFQTVGGWWAQVMLAQR VTIVTKKGEITGVIGSKPPHILSPEARKKSVEIKDMFIDIGASSREEALEWGVLPGDM IVPHFEFTVMNNEKFLLAKAWDNRIGCAIAIDVLRNLQNTDHPNIVYGVGTVQEEVGL RGAKTAAHTIQPDIAFGVDVGIAGDTPGISEKEAQSKMGKGPQIIVYDASMVSHKGLR DAVVATAEEAGIPYQFDAIAGGGTDSGAIHLTANGVPALSITIATRYIHTHAAMLHRD DYENAVKLITEVIKKLDRKTVDEITYQ*" /label="frvX CDS" gene complement(2446993..2448078) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /label="frvX gene" downshifts complement(2447007) /Source="Nicolas_upshifts" /id="D1473" /incds=0 /nref=233 /ntot=262 /MaxReadThrough="3.55686" /MaxDrop="6.91328" /score="-0.475558157" /energy="-9.9" /TU="U2227" /idTUdmin="U2227" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2448104..2448123) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-10" upshifts complement(2448127) /Source="Nicolas_upshifts" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2448138..2448145) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-35" promotor_-35 2448196..2448205 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2448211 /Source="Nicolas_upshifts" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2448217..2448232 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2448262..2448654 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10960106, 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390761.1" /db_xref="EnsemblGenomes-Gn:BSU28830" /db_xref="EnsemblGenomes-Tr:CAB14843" /db_xref="GOA:P94520" /db_xref="SubtiList:BG12316" /db_xref="UniProtKB/Swiss-Prot:P94520" /translation="MFVMVLRIILLALFAYCIYAVVKYVANPKRRLKLAQSKEHFYII DEQNNTRKNFQLTYKGVLFEGEKHIPSKDHPLFIHTIFVWTESPEKLKHFSAKDFENI EEKVLERYPNCKIDWDQPIKLAKKAEER*" /label="ysdB CDS" gene 2448262..2448654 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /label="ysdB gene" downshifts 2448625 /Source="Nicolas_upshifts" /id="D1474" /incds=0 /nref=86 /ntot=229 /MaxReadThrough="5.09744" /MaxDrop="4.57118" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-2112" /isTUend="FALSE" /label="downshifts" S_feature 2448670..2448976 /Source="Nicolas_S_feature" /locus_tag="new_2951898_2952204" /HighExp="Etha, M9-stat, T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, S8, T3.30H, Salt" /AntisenseName="ysdA" /AntisenseCor="-0.31305612685159701" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1088" CDS complement(2448670..2448939) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17289755; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_390762.1" /db_xref="EnsemblGenomes-Gn:BSU28840" /db_xref="EnsemblGenomes-Tr:CAB14844" /db_xref="GOA:P94519" /db_xref="InterPro:IPR010718" /db_xref="SubtiList:BG12315" /db_xref="UniProtKB/Swiss-Prot:P94519" /translation="MIIAAYLVLINLCGFWVMGIDKRKAQQHKWRISEDRLWLIAIVF GALGVWLGMQTFRHKTKHASFKYGVPLLLVIEAILIAIYYSPFDL*" /label="ysdA CDS" gene complement(2448670..2448939) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /label="ysdA gene" downshifts complement(2448686) /Source="Nicolas_upshifts" /id="D1475" /incds=0 /nref=6 /ntot=206 /MaxReadThrough="2.53274" /MaxDrop="3.80421" /score="20.1281719" /energy="-14" /TU="U2229" /idTUdmin="U2230" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" downshifts complement(2448855) /Source="Nicolas_upshifts" /id="D1476" /incds=1 /nref=1 /ntot=37 /MaxReadThrough="4.90568" /MaxDrop="2.19601" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2448933 /Source="Nicolas_upshifts" /id="D1477" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="4.08794" /MaxDrop="3.37039" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" CDS complement(2448996..2449355) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L20" /protein_id="NP_390763.1" /db_xref="EnsemblGenomes-Gn:BSU28850" /db_xref="EnsemblGenomes-Tr:CAB14845" /db_xref="GOA:P55873" /db_xref="InterPro:IPR005813" /db_xref="InterPro:IPR035566" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11971" /db_xref="UniProtKB/Swiss-Prot:P55873" /translation="MPRVKGGTVTRKRRKKVLKLAKGYFGSKHTLYKVANQQVMKSGN YAFRDRRQKKRDFRKLWITRINAAARMNGLSYSRLMHGLKLSGIEVNRKMLADLAVND LTAFNQLADAAKAQLNK*" /label="rplT CDS" gene complement(2448996..2449355) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /label="rplT gene" downshifts complement(2449009) /Source="Nicolas_upshifts" /id="D1478" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="5.94351" /MaxDrop="6.27682" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(2449387..2449587) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L35" /protein_id="NP_390764.1" /db_xref="EnsemblGenomes-Gn:BSU28860" /db_xref="EnsemblGenomes-Tr:CAB14846" /db_xref="GOA:P55874" /db_xref="InterPro:IPR001706" /db_xref="InterPro:IPR018265" /db_xref="InterPro:IPR021137" /db_xref="InterPro:IPR037229" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11972" /db_xref="UniProtKB/Swiss-Prot:P55874" /translation="MPKMKTHRGSAKRFKKTGSGKLKRSHAYTSHLFANKSQKQKRKL RKSAVVSAGDFKRIKQMLANIK*" /label="rpmI CDS" gene complement(2449387..2449587) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /label="rpmI gene" CDS complement(2449600..2450121) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-3" /protein_id="NP_390765.1" /db_xref="EnsemblGenomes-Gn:BSU28870" /db_xref="EnsemblGenomes-Tr:CAB14847" /db_xref="GOA:P55872" /db_xref="InterPro:IPR001288" /db_xref="InterPro:IPR019813" /db_xref="InterPro:IPR019814" /db_xref="InterPro:IPR019815" /db_xref="InterPro:IPR036787" /db_xref="InterPro:IPR036788" /db_xref="SubtiList:BG11944" /db_xref="UniProtKB/Swiss-Prot:P55872" /translation="MISKDQLVNEGIRAREVRLIGQNGDQLGIKSRQEALEIAGRANL DLVLVAANAKPPVCRIMDYGKFRFEQQKKEKEARKNQKIINLKEVRLSPTIDEHDFNT KLRNAIKFLEKGDKVKASIRFKGRAITHKEIGQRVLDRFSEACAEVATVETKPKMDGR SMFLMLAPKNEKQ*" /label="infC CDS" gene complement(2449600..2450121) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /label="infC gene" misc_RNA complement(2450183..2450322) /locus_tag="BSU_misc_RNA_47" /product="mRNA L20_leader attenuator sequence" /experiment="publication(s) with functional evidences, PMID:17289755, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17289755, 23611891" /label="mRNA L20 leader attenuator sequence" gene complement(2450183..2450322) /locus_tag="BSU_misc_RNA_47" /label="gene" promotor_-10 complement(2450319..2450338) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2450329) /Source="Nicolas_upshifts" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2450331..2450395) /Source="Nicolas_S_feature" /locus_tag="new_2953559_2953623_c" /HighExp="Paraq, G180, G150, G135, H2O2, LPh, C30, Oxctl, LBGexp, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1089" promotor_-35 complement(2450352..2450359) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2450377..2450396) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2450395) /Source="Nicolas_upshifts" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2450412..2450416) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2450514..2450521 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2450535..2450553 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2450535 /Source="Nicolas_upshifts" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="upshifts" CDS 2450567..2451232 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /function="14: Cell envelope" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390767.2" /db_xref="EnsemblGenomes-Gn:BSU28890" /db_xref="EnsemblGenomes-Tr:CAB14849" /db_xref="SubtiList:BG12314" /db_xref="UniProtKB/Swiss-Prot:P94517" /translation="MNKLIQLALFFTLMLTGCSNSSTSSESKVETTVKTTAAFPQKEL EKELKKLKPVSLDMKFESPLATELGKRKAKEEAEKQRQIAAEKKLEKEREAKRKKQQE EKAERQRLAEQQAAERQRLAEAERQAELERQRQAAIQKEQKANAEKKRQSQAQRQQTE APSSNSQDPPSSSSQTDKTIQQPASELPDDDGYGYEERKKWHDDQVEWGIKQGYIDPE DAP*" /label="yscB CDS" gene 2450567..2451232 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /label="yscB gene" downshifts 2451210 /Source="Nicolas_upshifts" /id="D1479" /incds=0 /nref=27 /ntot=178 /MaxReadThrough="2.51181" /MaxDrop="3.43861" /score="13.4996084" /energy="-15.8" /TU="NA" /idTUdmin="U2231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2451264..2451959) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /function="16.5: Explore" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pyruvate import system subunit B" /protein_id="NP_390768.1" /db_xref="EnsemblGenomes-Gn:BSU28900" /db_xref="EnsemblGenomes-Tr:CAB14850" /db_xref="GOA:P94516" /db_xref="InterPro:IPR007300" /db_xref="InterPro:IPR024891" /db_xref="SubtiList:BG12312" /db_xref="UniProtKB/Swiss-Prot:P94516" /translation="MESTMSPYFGIVVSLAAFGIGTFLFKKTKGFFLFTPLFVAMVLG IAFLKIGGFSYADYNNGGEIIKFFLEPATIAFAIPLYKQRDKLKKYWWQIMASIIAGS ICSVTIVYLLAKGIHLDSAVMKSMLPQAATTAIALPLSKGIGGISDITAFAVIFNAVI VYALGALFLKVFKVKNPISKGLALGTSGHALGVAVGIEMGEVEAAMASIAVVVVGVVT VLVIPVFVQLIGG*" /label="pftB CDS" gene complement(2451264..2451959) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /label="pftB gene" downshifts complement(2451286) /Source="Nicolas_upshifts" /id="D1480" /incds=0 /nref=19 /ntot=45 /MaxReadThrough="1.25312" /MaxDrop="6.13174" /score="49.3872074" /energy="-13.7" /TU="NA" /idTUdmin="U2232" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2451330) /Source="Nicolas_upshifts" /id="D1481" /incds=1 /nref=2 /ntot=36 /MaxReadThrough="6.79502" /MaxDrop="3.1016" /score="49.3872074" /energy="-13.7" /TU="U2232" /idTUdmin="U2232" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(2451981..2452421) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15659658, 17452642, 26060272, 27422364, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15659658, 17452642, 26060272, 27422364, 28974613; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyruvate uptake system subunit A" /protein_id="NP_390769.1" /db_xref="EnsemblGenomes-Gn:BSU28910" /db_xref="EnsemblGenomes-Tr:CAB14851" /db_xref="GOA:P94515" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023736" /db_xref="SubtiList:BG12311" /db_xref="UniProtKB/Swiss-Prot:P94515" /translation="MSAKKVYGFLTQAFIFAVIMLVSNMIAAIVPIPIPASVVGLVLL FLLLCLKVIKLEQVETLGTSLTSLIGFLFVPSGISVMNSLGVMQQYGLQIVLVILLAT IILLGATGLFSQLILSLSGKRKTEADMKTKTVQSPQNNNELVHH*" /label="pftA CDS" gene complement(2451981..2452421) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /label="pftA gene" promotor_-10 complement(2452443..2452462) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2452462) /Source="Nicolas_upshifts" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2452478..2452481) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2452555..2453280) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LytS]" /protein_id="NP_390770.1" /db_xref="EnsemblGenomes-Gn:BSU28920" /db_xref="EnsemblGenomes-Tr:CAB14852" /db_xref="GOA:P94514" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11953" /db_xref="UniProtKB/Swiss-Prot:P94514" /translation="MLRVLIVDDEMLARDELAYLLKRTNDEMEINEAENIESAFDQMM DQKPDLLFLDVDLSGENGFDIAKRLKKMKHPPAIVFATAYDQYALKAFEVDALDYLTK PFDEERIQQTLKKYKKVNRDIVETEQNSHAGQHKLALSVGESIVIVDTKDIIYAGTED GHVNVKTFDHSYTVSDTLVVIEKKLPDSDFIRVHRSFVVNTEYIKEIQPWFNSTYNLI MKDGSKIPVSRTYAKELKKLLHI*" /label="lytT CDS" gene complement(2452555..2453280) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /label="lytT gene" downshifts complement(2452584) /Source="Nicolas_upshifts" /id="D1482" /incds=0 /nref=231 /ntot=256 /MaxReadThrough="-0.0173499999999995" /MaxDrop="6.64673" /score="-8.47161605" /energy="-8.9" /TU="NA" /idTUdmin="U2232" /TUdmin="-1298" /isTUend="FALSE" /label="downshifts" CDS complement(2453258..2455039) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /function="16.3: Control" /function="16.13: Shape" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LytT]" /protein_id="NP_390771.1" /db_xref="EnsemblGenomes-Gn:BSU28930" /db_xref="EnsemblGenomes-Tr:CAB14853" /db_xref="GOA:P94513" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11952" /db_xref="UniProtKB/Swiss-Prot:P94513" /translation="MIHLMIMMLERVGIIVILGFILAHTKLFRQALQNQDGYKGKAIL ISIFSLFSIISNYTGIEIQRNMIVNNDWVFTIDPSGSIANTRILGVEIGGLLGGPFVG AGIGILAGLHRFSLGGSTALSCAVSSILAGVLAGLIGRYFTKRYRMPTPRIAALVGIG MESLQMIIILLMAKPFSDAWELVSMIGIPMILINGTGSFIFLSIIQAIIRKEEQARAL ETHRVLTIADQTLPFFRQGLNENSCKSVAAIIHKLTGTDAVSLTDKEKILAHVGAGMD HHIPSKSLITGLSKKVIKTGHIMKAISQEEIECTHAECPLHAAIVLPLTSNGNTIGTL KMYFKSPAGLSQVEEELAEGLAMLFSTQLELGEAELQSKLLKDAEIKALQAQVNPHFL FNAINTISALCRTDVEKTRKLLLQLSVYFRSNLQGARQLLIPLSKELNHLNAYLSLEQ ARFPGKYKIELNIDSRLEQIEIPPFVLQVLVENALRHAFPKKQDICKVTVCVLSDDAS VYMKVADNGRGIPPDVLPELGKKPFPSKEGTGTALYNLNQRLIGLFGQQAALHISSEV HKGTEVSFQVPMQQMKEGEEHAQGVNS*" /label="lytS CDS" gene complement(2453258..2455039) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /label="lytS gene" promotor_-35 2455123..2455126 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2455135..2455154) /Source="Nicolas_upshift_promotors" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2455140) /Source="Nicolas_upshifts" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2455141..2455160 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2455148 /Source="Nicolas_upshifts" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2455206..2455988 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:15479782, 24123841, 25848029, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15479782, 24123841, 25848029, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase" /protein_id="NP_390772.2" /db_xref="EnsemblGenomes-Gn:BSU28940" /db_xref="EnsemblGenomes-Tr:CAB14854" /db_xref="GOA:P94512" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12310" /db_xref="UniProtKB/Swiss-Prot:P94512" /translation="MKAVFFDLDDTLLWDEKSVRTTFAETCLQAEKKYGLAPEEFEAA VREAARELYMSYETYPYTVMIGINPFEGLWSNFSEPISEGFQKLNKIVPEYRRNAWTN GLKALGIDDPAYGEYLGEFFAAERRKRPFVYDETFAVLDQLKGKYELLLLTNGDPSLQ KEKLAGVPELAPYFNEIVISGAFGKGKPDVSIFEHCLKLMNIEKDDAIMVGDNLNTDI LGASRAGIKTVWINRTDKKNETDVKPDYIISSLHDLFPILEK*" /label="ysaA CDS" gene 2455206..2455988 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /label="ysaA gene" downshifts 2455972 /Source="Nicolas_upshifts" /id="D1483" /incds=0 /nref=36 /ntot=265 /MaxReadThrough="1.0046" /MaxDrop="6.73727" /score="35.9560361" /energy="-13.8" /TU="NA" /idTUdmin="U2234" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" downshifts complement(2456022) /Source="Nicolas_upshifts" /id="D1484" /incds=0 /nref=89 /ntot=246 /MaxReadThrough="1.13716" /MaxDrop="6.01766" /score="35.534455" /energy="-13.8" /TU="NA" /idTUdmin="U2235" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2456029..2457960) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8692931, 9826762, 10632708, 15831787, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8692931, 9826762, 10632708, 15831787, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_390773.1" /db_xref="EnsemblGenomes-Gn:BSU28950" /db_xref="EnsemblGenomes-Tr:CAB14855" /db_xref="GOA:P18255" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10362" /db_xref="UniProtKB/Swiss-Prot:P18255" /translation="MSDMVKITFPDGAVKEFAKGTTTEDIAASISPGLKKKSLAGKLN GKEIDLRTPINEDGTVEIITEGSEEGLQIMRHSAAHLLAQAIKRIYKDVKFGVGPVIE NGFYYDVEMDEAITPEDLPKIEKEMKKIVNANLPIVRKEVSREEAKARFAEIGDDLKL ELLDAIPEGETVSIYEQGEFFDLCRGVHVPSTGKIKEFKLLSLAGAYWRGDSKNQMLQ RVYGTAFFKKADLEEHLRMLEEAKERDHRKLGKELKLFANSQKVGQGLPLWLPKGATI RRVIERYIVDKEISLGYEHVYTPVLGSKELYETSGHWDHYQEGMFPPMEMDNETLVLR PMNCPHHMMIYKQDIHSYRELPIRIAELGTMHRYEMSGALSGLQRVRGMTLNDAHIFV RPDQIKDEFIRTVRLIQDVYEDFGLSDYTFRLSYRDPEDTEKYFDDDEMWNKAQSMLK EAMDEIGHDYYEAEGEAAFYGPKLDVQVKTAIGKEETLSTVQLDFLLPERFDLTYIGE DGKQHRPVVIHRGVVSTMERFVAFLIEEHKGALPTWLAPVQFQVIPVSPAVHLDYAKK VQERLQCEGLRVEVDSRDEKIGYKIREAQMQKIPYMLVVGDQEAENGAVNVRKYGEQN SETISLDEFVKKAVAEAKK*" /label="thrS CDS" gene complement(2456029..2457960) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /label="thrS gene" misc_RNA complement(2458004..2458251) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:9098041, 9826762, 1317842, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 9826762, 1317842, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboT RNA" gene complement(2458004..2458251) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /label="tboT gene" promotor_-10 complement(2458007..2458016) /Source="Nicolas_upshift_promotors" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2458007) /Source="Nicolas_upshifts" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2458062) /Source="Nicolas_upshifts" /id="D1485" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="6.71261" /MaxDrop="3.31801" /score="19.160794" /energy="-16.2" /TU="U2236,U2237,U2238,U2241" /idTUdmin="U2239" /TUdmin=221 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2458262..2458281) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2458275) /Source="Nicolas_upshifts" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2458277..2458357) /Source="Nicolas_S_feature" /locus_tag="new_2961505_2961585_c" /HighExp="S3, S4, LoTm, S5, G135, G180, LBGtran, T5.0H, G/S, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1090" promotor_-35 complement(2458297..2458301) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2458358..2459203) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22882546; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation protein" /protein_id="NP_390774.2" /db_xref="EnsemblGenomes-Gn:BSU28960" /db_xref="EnsemblGenomes-Tr:CAB14856" /db_xref="InterPro:IPR014199" /db_xref="SubtiList:BG10361" /db_xref="UniProtKB/Swiss-Prot:P06569" /translation="MLEIIFEDDHDAAAFLHLIQHSDDRNNIIVREGIRKIGIEKANP AFPIQRFMEPILVKFFLECKEDEHMLSLIEETYCFTDQDEQQQILQLAHSIIEGEADD LPFEPLKLSRKQSILDELQTICLEEGVFYIRSFQTFRLGSYYKQLRDITEAAIDEYKM EQEYQNFIQTLRDYVDAKQPRIKKVHIVHDGSFTLWELRYVPEREKMKYIDRRFVRDH PMYIDSHLLAPLISIAPDEVVLYTDQPEHMMARTIQNVFQERVEMLPLHAFTDAEIPV KHSEG*" /label="ytxC CDS" gene complement(2458358..2459203) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /label="ytxC gene" promotor_-10 complement(2459223..2459241) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2459229) /Source="Nicolas_upshifts" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2459257..2459262) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2459282..2459923) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25728272, 27190159; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative osomosensing transporter" /protein_id="NP_390775.1" /db_xref="EnsemblGenomes-Gn:BSU28970" /db_xref="EnsemblGenomes-Tr:CAB14857" /db_xref="GOA:P06568" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG10360" /db_xref="UniProtKB/Swiss-Prot:P06568" /translation="MKRKTAVKWLAVLAGAGLLYWGNKTYLNVSPKEIRVWVLSFGVF APLMFIGISIVRPLVLFPVSVISIAGGLAFGPLLGTLYTLFGSMCASAVSFFAAGLFS AKKNGHYERLEAIQKQMEDNGFFYIFLLRILPINFDFVSYAAGLSNVKALPYFAATAV GIIPGTIALNVLGASFLAGNLPAFFMVLALYIVFISLPFIFRKKMQNLFQESN*" /label="ytxB CDS" gene complement(2459282..2459923) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /label="ytxB gene" CDS complement(2459957..2460892) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 17003052, 17289076, 19255093, 19968790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17003052, 17289076, 19255093, 19968790; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loader" /protein_id="NP_390776.1" /db_xref="EnsemblGenomes-Gn:BSU28980" /db_xref="EnsemblGenomes-Tr:CAB14858" /db_xref="GOA:P06567" /db_xref="InterPro:IPR002611" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009928" /db_xref="InterPro:IPR027417" /db_xref="PDB:2K7R" /db_xref="PDB:4M4W" /db_xref="SubtiList:BG10359" /db_xref="UniProtKB/Swiss-Prot:P06567" /translation="MEPIGRSLQGVTGRPDFQKRLEQMKEKVMKDQDVQAFLKENEEV IDQKMIEKSLNKLYEYIEQSKNCSYCSEDENCNNLLEGYHPKLVVNGRSIDIEYYECP VKRKLDQQKKQQSLMKSMYIQQDLLGATFQQVDISDPSRLAMFQHVTDFLKSYNETGK GKGLYLYGKFGVGKTFMLAAIANELAEKEYSSMIVYVPEFVRELKNSLQDQTLEEKLN MVKTTPVLMLDDIGAESMTSWVRDEVIGTVLQHRMSQQLPTFFSSNFSPDELKHHFTY SQRGEKEEVKAARLMERILYLAAPIRLDGENRRHP*" /label="dnaI CDS" gene complement(2459957..2460892) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /label="dnaI gene" CDS complement(2460920..2462338) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loading protein; replication initiationmembrane attachment protein" /protein_id="NP_390777.1" /db_xref="EnsemblGenomes-Gn:BSU28990" /db_xref="EnsemblGenomes-Tr:CAB14859" /db_xref="GOA:P07908" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="SubtiList:BG10358" /db_xref="UniProtKB/Swiss-Prot:P07908" /translation="MADYWKDVLPVDPYVVKSRSMLQDIDRQIITQLYQPLIGPVAFS LYMTLWGELEQNRLWGGESTHRQLMGMTQSNLKTIHQEQGKLEGIGLLKVYMKESERQ ERLFIYELLPPLRPNEFFEDGMLNVFLYNRVGKTKYQQLKQFFTHPAISEDAKDITRP FNHAFESLQPSEWKLTSDMEETVRLAEGSEYTSVGQSPSYTITEDVFDFDLFLAGLSE TMIPRKAMTQQVRDTIKKLSYLYGIDPLQMQNVVMSAIDERDVITTEALRKAASDWYQ IERNGQLPDLVEKTQPVHLREGEQPAEEDSLDGKLIALLEAISPKKLLQDIADGTEPS KADLKIIEEIMFEQKLEPGVTNVLIYYVMLKTDMKLSKNYIQKIASHWARKKVKTVRE AMKLAIEENRQYLEWAEGKTKSSKRNQKVIREEKLPDWMTEKETASDSESGQQKLHPQ DLEEQKKKMMEEMQKLKKYSAY*" /label="dnaB CDS" gene complement(2460920..2462338) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /label="dnaB gene" promotor_-10 complement(2462367..2462386) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2462375) /Source="Nicolas_upshifts" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2462401..2462404) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2462453..2462911) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16950922, 27920297, 28624879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950922, 27920297, 28624879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of transcription of ribonucleotide reductase nrd genes and operons" /protein_id="NP_390778.1" /db_xref="EnsemblGenomes-Gn:BSU29000" /db_xref="EnsemblGenomes-Tr:CAB14860" /db_xref="GOA:Q45549" /db_xref="InterPro:IPR003796" /db_xref="InterPro:IPR005144" /db_xref="SubtiList:BG13833" /db_xref="UniProtKB/Swiss-Prot:Q45549" /translation="MKCPSCQHNGTRVLDSRPVDDGKSIRRRRECESCHYRFTTFEKV EETPLIVVKKEGVREEFSREKMLRGLIKACEKRPVSLKTLEDMCFDIEKELRNQGCSE VKSELVGEMVMDRLAKIDEVAYVRFASVYRQFKDINVFIDELKDLIKKER*" /label="nrdR CDS" gene complement(2462453..2462911) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /label="nrdR gene" downshifts complement(2462472) /Source="Nicolas_upshifts" /id="D1486" /incds=0 /nref=14 /ntot=175 /MaxReadThrough="4.1553" /MaxDrop="3.90408" /score="12.4797073" /energy="-21.2" /TU="U2239,U2241" /idTUdmin="U2243" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2462912..2463059) /Source="Nicolas_S_feature" /locus_tag="new_2966140_2966287_c" /HighExp="dia5, dia15, Lbstat, Diami, Heat, M9-stat, M0t90, M40t90, LBGtran, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, SigA" /TUshortPSig="0.998, 0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1091" promotor_-10 complement(2463050..2463069) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-10" upshifts complement(2463059) /Source="Nicolas_upshifts" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="upshifts" S_feature complement(2463061..2463139) /Source="Nicolas_S_feature" /locus_tag="new_2966289_2966367_c" /HighExp="Lbstat, M40t90, Heat, M9-stat, M0t90, G180, S8, S5, T1.30H, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1092" promotor_-35 complement(2463084..2463087) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-35" downshifts complement(2463184) /Source="Nicolas_upshifts" /id="D1487" /incds=0 /nref=204 /ntot=262 /MaxReadThrough="5.70146" /MaxDrop="5.85416" /score="12.4797073" /energy="-21.2" /TU="U2241,U2242,U2243" /idTUdmin="U2242" /TUdmin="-237" /isTUend="FALSE" /label="downshifts" CDS complement(2463185..2463565) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /EC_number="4.1.1.50" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 10844697, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10844697, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine decarboxylase" /protein_id="NP_390779.2" /db_xref="EnsemblGenomes-Gn:BSU29010" /db_xref="EnsemblGenomes-Tr:CAB14861" /db_xref="GOA:O34426" /db_xref="InterPro:IPR003826" /db_xref="InterPro:IPR016067" /db_xref="InterPro:IPR017716" /db_xref="SubtiList:BG13832" /db_xref="UniProtKB/Swiss-Prot:O34426" /translation="METMGRHVISELWGCDFDKLNDMDFIEKTFVNAALKSGAEVREV AFHKFAPQGVSGVVIISESHLTIHSFPEHGYASIDVYTCGDLDPNVAADYIAEALHAD TRENIEIPRGMGPVQIKQAQAKVL*" /label="speD CDS" gene complement(2463185..2463565) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /label="speD gene" S_feature complement(2463566..2463720) /Source="Nicolas_S_feature" /locus_tag="new_2966794_2966948_c" /HighExp="Lbstat, M40t90, M9-stat, T2.0H, T3.0H, M0t90, T3.30H, Sw, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1093" promotor_-10 complement(2463700..2463719) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2463707 /Source="Nicolas_upshifts" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2463708..2463727 /Source="Nicolas_upshift_promotors" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2463720) /Source="Nicolas_upshifts" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2463734..2463740) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2463798..2463809) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2463804..2464826) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /EC_number="1.2.1.59" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NADP-dependent, gluconeogenesis)" /protein_id="NP_390780.1" /db_xref="EnsemblGenomes-Gn:BSU29020" /db_xref="EnsemblGenomes-Tr:CAB14862" /db_xref="GOA:O34425" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12592" /db_xref="UniProtKB/Swiss-Prot:O34425" /translation="MKVKVAINGFGRIGRMVFRKAMLDDQIQVVAINASYSAETLAHL IKYDTIHGRYDKEVVAGEDSLIVNGKKVLLLNSRDPKQLPWREYDIDIVVEATGKFNA KDKAMGHIEAGAKKVILTAPGKNEDVTIVMGVNEDQFDAERHVIISNASCTTNCLAPV VKVLDEEFGIESGLMTTVHAYTNDQKNIDNPHKDLRRARACGESIIPTTTGAAKALSL VLPHLKGKLHGLALRVPVPNVSLVDLVVDLKTDVTAEEVNEAFKRAAKTSMYGVLDYS DEPLVSTDYNTNPHSAVIDGLTTMVMEDRKVKVLAWYDNEWGYSCRVVDLIRHVAARM KHPSAV*" /label="gapB CDS" gene complement(2463804..2464826) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /label="gapB gene" upshifts complement(2463805) /Source="Nicolas_upshifts" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2463824..2463830) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2464870..2464889) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2464901) /Source="Nicolas_upshifts" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2464902..2464909) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2465032..2465412) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HxlR family)" /protein_id="NP_390781.1" /db_xref="EnsemblGenomes-Gn:BSU29030" /db_xref="EnsemblGenomes-Tr:CAB14863" /db_xref="GOA:O34533" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HZT" /db_xref="SubtiList:BG13831" /db_xref="UniProtKB/Swiss-Prot:O34533" /translation="MEKKKYNISVEATLEVIGGKWKCVILCHLTHGKKRTSELKRLMP NITQKMLTQQLRELEADGVINRIVYNQVPPKVEYELSEYGRSLEGILDMLCAWGANHI NRVYGDTFSVLEESVLNDKLKQES*" /label="ytcD CDS" gene complement(2465032..2465412) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /label="ytcD gene" downshifts complement(2465056) /Source="Nicolas_upshifts" /id="D1488" /incds=0 /nref=17 /ntot=164 /MaxReadThrough="1.55675" /MaxDrop="3.64816" /score="18.9828659" /energy="-15.3" /TU="NA" /idTUdmin="U2245" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(2465413..2465543) /Source="Nicolas_S_feature" /locus_tag="new_2968641_2968771_c" /HighExp="dia15, Diami, dia5, LBGstat, G180, Etha, S5, LBGtran, H2O2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1094" promotor_-35 2465468..2465472 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2465488..2465507 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2465489..2465595 /Source="Nicolas_S_feature" /locus_tag="new_2968717_2968823" /HighExp="Diami, G180, G135, LBGstat, G150, LBGexp, Paraq, Oxctl, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1095" upshifts 2465489 /Source="Nicolas_upshifts" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2465533..2465552) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2465543) /Source="Nicolas_upshifts" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2465567..2465574) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2465596..2466786 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390782.1" /db_xref="EnsemblGenomes-Gn:BSU29040" /db_xref="EnsemblGenomes-Tr:CAB14864" /db_xref="GOA:O34367" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13825" /db_xref="UniProtKB/Swiss-Prot:O34367" /translation="MTSANKSNIPALLALAVSAFAIGTTEFISVGLLPLIADDLDIPV TTAGLTVSLYALGVTFGAPILTSLTSSMSRKTLLLWIMFIFIAGNTMAATASSIGILL AARVISAFSHGVFMSIGSTIAADIVPEDKRASAISIMFTGLTVATVTGVPFGTFIGQQ FGWRFAFMVIIAVGIIAFITNGILVPSKLRKGTKTTMRDQLKLVTNSRLLLLFVITAL GYGGTFVVFTYLSPLLQEVTGFKAGTVAVILLGYGIAIAIGNMIGGKLSNRNPIAALF YMFIVQAIVLFVLTFTAPYQAAGLITILCMGLLAFMNVPGLQVYVVMLAERFVPSAVD VASAMNIAAFNAGIALGSYLGGVITDSIGLIHTAWIGGLMVVGAVILTGWSRLMEKRD RQEA*" /label="ytbD CDS" gene 2465596..2466786 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /label="ytbD gene" promotor_-10 complement(2466418..2466436) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2466434) /Source="Nicolas_upshifts" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2466452..2466457) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2466810..2467652 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /EC_number="1.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19585557, 20981419, 28032445, 28130301" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19585557, 20981419, 28032445, 28130301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aldo/keto reductase" /protein_id="NP_390783.1" /db_xref="EnsemblGenomes-Gn:BSU29050" /db_xref="EnsemblGenomes-Tr:CAB14865" /db_xref="GOA:O34678" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3B3D" /db_xref="SubtiList:BG13826" /db_xref="UniProtKB/Swiss-Prot:O34678" /translation="MTTHLQAKATLHNGVEMPWFGLGVFQVEEGSELVNAVKTAIVHG YRSIDTAAIYGNEAGVGEGIREGIEEAGISREDLFITSKVWNADLGYEETLAAFETSL SKLGLDYLDLYLIHWPVEGKYKEAWRALETLYKEGRIKAIGVSNFQIHHLEDLMTAAE IKPMINQVEFHPRLTQKELIRYCQNQGIQMEAWSPLMQGQLLDHPVLADIAQTYNKSV AQIILRWDLQHGIITIPKSTKEHRIKENASVFDFELTQDDMNRIDALNENLRVGPDPD NFDF*" /label="ytbE CDS" gene 2466810..2467652 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /label="ytbE gene" promotor_-35 2467425..2467430 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2467446..2467464 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2467447 /Source="Nicolas_upshifts" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2467645 /Source="Nicolas_upshifts" /id="D1489" /incds=0 /nref=13 /ntot=124 /MaxReadThrough="1.16017" /MaxDrop="5.72508" /score="24.0721062" /energy="-11.4" /TU="NA" /idTUdmin="U2244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2467685) /Source="Nicolas_upshifts" /id="D1490" /incds=0 /nref=168 /ntot=263 /MaxReadThrough="3.38494" /MaxDrop="6.57333" /score="13.4291259" /energy="-11.4" /TU="NA" /idTUdmin="U2248" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2467694..2468287) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /EC_number="2.7.1.24" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 11886213, 12538896, 12682299, 15044829, 15526298, 17603993; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphocoenzyme A kinase" /protein_id="NP_390784.1" /db_xref="EnsemblGenomes-Gn:BSU29060" /db_xref="EnsemblGenomes-Tr:CAB14866" /db_xref="GOA:O34932" /db_xref="InterPro:IPR001977" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13824" /db_xref="UniProtKB/Swiss-Prot:O34932" /translation="MTLVIGLTGGIASGKSTVANMLIEKGITVIDADIIAKQAVEKGM PAYRQIIDEFGEDILLSNGDIDRKKLGALVFTNEQKRLALNAIVHPAVRQEMLNRRDE AVANREAFVVLDIPLLFESKLESLVDKIIVVSVTKELQLERLMKRNQLTEEEAVSRIR SQMPLEEKTARADQVIDNSGTLEETKRQLDEIMNSWA*" /label="coaE CDS" gene complement(2467694..2468287) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /label="coaE gene" CDS complement(2468303..2468935) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23396918; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane calmodulin-like protein essential for stage III sporulation" /protein_id="NP_390785.2" /db_xref="EnsemblGenomes-Gn:BSU29070" /db_xref="EnsemblGenomes-Tr:CAB14867" /db_xref="GOA:C0SP79" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR014205" /db_xref="SubtiList:BG13823" /db_xref="UniProtKB/Swiss-Prot:C0SP79" /translation="MQMVSILLLALAVSLDSFSVGFTYGLRKMKIPFKAILVIACCSG AVMFISMLIGSFLTKFFPVYVTEKLGGLILVGIGAWVLYQFFKPAKDKEYLLHEKTLL NLEVRSLGIVIHILRKPMSADIDKSGVINGIEAVLLGFALSIDAFGAGIGAAILGFSP IVMSIAVAIMSSLFVSIGINAGHFLSKWKWIDKMAFLPGLLLITIGLWKL*" /label="spcF CDS" gene complement(2468303..2468935) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /label="spcF gene" S_feature complement(2468936..2469100) /Source="Nicolas_S_feature" /locus_tag="new_2972164_2972328_c" /HighExp="LPhT, dia15, Sw, LBGtran, LBGstat, H2O2, Diami, G135, Lbstat, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1096" CDS complement(2469101..2469931) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /EC_number="3.2.2.23" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15109717, 25825434, 28517932; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formamidopyrimidine-DNA glycosylase; 5-hydroxymethyl-uracil DNA-glycosylase" /protein_id="NP_390786.2" /db_xref="EnsemblGenomes-Gn:BSU29080" /db_xref="EnsemblGenomes-Tr:CAB14868" /db_xref="GOA:O34403" /db_xref="InterPro:IPR000214" /db_xref="InterPro:IPR010663" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR012319" /db_xref="InterPro:IPR015886" /db_xref="InterPro:IPR015887" /db_xref="InterPro:IPR020629" /db_xref="InterPro:IPR035937" /db_xref="SubtiList:BG12628" /db_xref="UniProtKB/Swiss-Prot:O34403" /translation="MPELPEVETVRRTLTGLVKGKTIKSVEIRWPNIIKRPAEPEEFA RKLAGETIQSIGRRGKFLLFHLDHYVMVSHLRMEGKYGLHQAEEPDDKHVHVIFTMTD GTQLRYRDVRKFGTMHLFKPGEEAGELPLSQLGPEPDAEEFTSAYLKDRLAKTNRAVK TALLDQKTVVGLGNIYVDEALFRAGVHPETKANQLSDKTIKTLHAEIKNTLQEAIDAG GSTVRSYINSQGEIGMFQLQHFVYGKKDEPCKNCGTMISKIVVGGRGTHFCAKCQTKK *" /label="mutM CDS" gene complement(2469101..2469931) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /label="mutM gene" CDS complement(2469954..2472596) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /EC_number="2.7.7.7" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3125407, 6777244, 9231429, 12081953, 17905985, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3125407, 6777244, 9231429, 12081953, 17905985, 27399782; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase I" /protein_id="NP_390787.1" /db_xref="EnsemblGenomes-Gn:BSU29090" /db_xref="EnsemblGenomes-Tr:CAB14869" /db_xref="GOA:O34996" /db_xref="InterPro:IPR001098" /db_xref="InterPro:IPR002298" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR002562" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR018320" /db_xref="InterPro:IPR019760" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12656" /db_xref="UniProtKB/Swiss-Prot:O34996" /translation="MTERKKLVLVDGNSLAYRAFFALPLLSNDKGVHTNAVYGFAMIL MKMLEDEKPTHMLVAFDAGKTTFRHGTFKEYKGGRQKTPPELSEQMPFIRELLDAYQI SRYELEQYEADDIIGTLAKSAEKDGFEVKVFSGDKDLTQLATDKTTVAITRKGITDVE FYTPEHVKEKYGLTPEQIIDMKGLMGDSSDNIPGVPGVGEKTAIKLLKQFDSVEKLLE SIDEVSGKKLKEKLEEFKDQALMSKELATIMTDAPIEVSVSGLEYQGFNREQVIAIFK DLGFNTLLERLGEDSAEAEQDQSLEDINVKTVTDVTSDILVSPSAFVVEQIGDNYHEE PILGFSIVNETGAYFIPKDIAVESEVFKEWVENDEQKKWVFDSKRAVVALRWQGIELK GAEFDTLLAAYIINPGNSYDDVASVAKDYGLHIVSSDESVYGKGAKRAVPSEDVLSEH LGRKALAIQSLREKLVQELENNDQLELFEELEMPLALILGEMESTGVKVDVDRLKRMG EELGAKLKEYEEKIHEIAGEPFNINSPKQLGVILFEKIGLPVVKKTKTGYSTSADVLE KLADKHDIVDYILQYRQIGKLQSTYIEGLLKVTRPDSHKVHTRFNQALTQTGRLSSTD PNLQNIPIRLEEGRKIRQAFVPSEKDWLIFAADYSQIELRVLAHISKDENLIEAFTND MDIHTKTAMDVFHVAKDEVTSAMRRQAKAVNFGIVYGISDYGLSQNLGITRKEAGAFI DRYLESFQGVKAYMEDSVQEAKQKGYVTTLMHRRRYIPELTSRNFNIRSFAERTAMNT PIQGSAADIIKKAMIDMAAKLKEKQLKARLLLQVHDELIFEAPKEEIEILEKLVPEVM EHALALDVPLKVDFASGPSWYDAK*" /label="polA CDS" gene complement(2469954..2472596) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /label="polA gene" promotor_-10 complement(2472651..2472670) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2472660) /Source="Nicolas_upshifts" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2472684..2472691) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2472720..2472839) /Source="Nicolas_S_feature" /locus_tag="new_2975948_2976067_c" /HighExp="M0t90, M40t90, M9-stat, Lbstat, Sw, T1.30H, T1.0H, S4, S3, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1097" downshifts complement(2472763) /Source="Nicolas_upshifts" /id="D1491" /incds=0 /nref=48 /ntot=175 /MaxReadThrough="5.58383" /MaxDrop="3.85702" /score="15.0073484" /energy="-12.2" /TU="U2249" /idTUdmin="U2254" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2472840..2474579) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_390788.1" /db_xref="EnsemblGenomes-Gn:BSU29100" /db_xref="EnsemblGenomes-Tr:CAB14870" /db_xref="GOA:P23545" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR031967" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3CWF" /db_xref="SubtiList:BG10364" /db_xref="UniProtKB/Swiss-Prot:P23545" /translation="MNKYRVRLFSVFVVCMILVFCVLGLFLQQLFETSDQRKAEEHIE KEAKYLASLLDAGNLNNQANEKIIKDAGGALDVSASVIDTDGKVLYGSNGRSADSQKV QALVSGHEGILSTTDNKLYYGLSLRSEGEKTGYVLLSASEKSDGLKGELWGMLTASLC TAFIVIVYFYSSMTSRYKRSIESATNVATELSKGNYDARTYGGYIRRSDKLGHAMNSL AIDLMEMTRTQEMQRDRLLTVIENIGSGLIMIDGRGFINLVNRSYAKQFHINPNHMLR RLYHDAFEHEEVIQLVEDIFMTETKKCKLLRLPIKIERRYFEVDGVPIMGPDDEWKGI VLVFHDMTETKKLEQMRKDFVANVSHELKTPITSIKGFTETLLDGAMEDKEALSEFLS IILKESERLQSLVQDLLDLSKIEQQNFTLSIETFEPAKMLGEIETLLKHKADEKGISL HLNVPKDPQYVSGDPYRLKQVFLNLVNNALTYTPEGGSVAINVKPREKDIQIEVADSG IGIQKEEIPRIFERFYRVDKDRSRNSGGTGLGLAIVKHLIEAHEGKIDVTSELGRGTV FTVTLKRAAEKSA*" /label="phoR CDS" gene complement(2472840..2474579) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /label="phoR gene" CDS complement(2474572..2475294) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_390789.2" /db_xref="EnsemblGenomes-Gn:BSU29110" /db_xref="EnsemblGenomes-Tr:CAB14871" /db_xref="GOA:P13792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1MVO" /db_xref="SubtiList:BG10363" /db_xref="UniProtKB/Swiss-Prot:P13792" /translation="MNKKILVVDDEESIVTLLQYNLERSGYDVITASDGEEALKKAET EKPDLIVLDVMLPKLDGIEVCKQLRQQKLMFPILMLTAKDEEFDKVLGLELGADDYMT KPFSPREVNARVKAILRRSEIAAPSSEMKNDEMEGQIVIGDLKILPDHYEAYFKESQL ELTPKEFELLLYLGRHKGRVLTRDLLLSAVWNYDFAGDTRIVDVHISHLRDKIENNTK KPIYIKTIRGLGYKLEEPKMNE*" /label="phoP CDS" gene complement(2474572..2475294) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /label="phoP gene" promotor_-10 complement(2475362..2475381) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2475372) /Source="Nicolas_upshifts" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2475374..2475474) /Source="Nicolas_S_feature" /locus_tag="new_2978602_2978702_c" /HighExp="M40t90, T1.30H, T1.0H, M0t90, M9-stat, T2.0H, T2.30H, T3.0H, T0.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1098" promotor_-35 complement(2475395..2475401) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2475506..2476444) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /EC_number="1.1.1.37" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate dehydrogenase (NAD-dependent)" /protein_id="NP_390790.1" /db_xref="EnsemblGenomes-Gn:BSU29120" /db_xref="EnsemblGenomes-Tr:CAB14872" /db_xref="GOA:P49814" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011275" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11386" /db_xref="UniProtKB/Swiss-Prot:P49814" /translation="MGNTRKKVSVIGAGFTGATTAFLIAQKELADVVLVDIPQLENPT KGKALDMLEASPVQGFDAKITGTSNYEDTAGSDIVVITAGIARKPGMSRDDLVSTNEK IMRSVTQEIVKYSPDSIIVVLTNPVDAMTYAVYKESGFPKERVIGQSGVLDTARFRTF VAEELNLSVKDVTGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERIDAIVERTRKGG GEIVNLLGNGSAYYAPAASLTEMVEAILKDQRRVLPTIAYLEGEYGYEGIYLGVPTIV GGNGLEQIIELELTDYERAQLNKSVESVKNVMKVLS*" /label="mdh CDS" gene complement(2475506..2476444) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /label="mdh gene" downshifts complement(2475519) /Source="Nicolas_upshifts" /id="D1492" /incds=0 /nref=200 /ntot=242 /MaxReadThrough="8.27126" /MaxDrop="7.40884" /score="-0.758981483" /energy="-13.5" /TU="U2251,U2254" /idTUdmin="U2250" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2476488..2477759) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /EC_number="1.1.1.42" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8045898, 9244258, 11290745, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045898, 9244258, 11290745, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isocitrate dehydrogenase" /protein_id="NP_390791.1" /db_xref="EnsemblGenomes-Gn:BSU29130" /db_xref="EnsemblGenomes-Tr:CAB14873" /db_xref="GOA:P39126" /db_xref="InterPro:IPR004439" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="PDB:1HQS" /db_xref="SubtiList:BG10856" /db_xref="UniProtKB/Swiss-Prot:P39126" /translation="MAQGEKITVSNGVLNVPNNPIIPFIEGDGTGPDIWNAASKVLEA AVEKAYKGEKKITWKEVYAGEKAYNKTGEWLPAETLDVIREYFIAIKGPLTTPVGGGI RSLNVALRQELDLFVCLRPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGS EEVQKLISFLQNELNVNKIRFPETSGIGIKPVSEEGTSRLVRAAIDYAIEHGRKSVTL VHKGNIMKFTEGAFKNWGYELAEKEYGDKVFTWAQYDRIAEEQGKDAANKAQSEAEAA GKIIIKDSIADIFLQQILTRPNEFDVVATMNLNGDYISDALAAQVGGIGIAPGANINY ETGHAIFEATHGTAPKYAGLDKVNPSSVILSGVLLLEHLGWNEAADLVIKSMEKTIAS KVVTYDFARLMDGATEVKCSEFGEELIKNMD*" /label="icd CDS" gene complement(2476488..2477759) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /label="icd gene" misc_feature complement(2477544..2477563) /Source="Nicolas_upshift_promotors" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2477556) /Source="Nicolas_upshifts" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2477760..2477842) /Source="Nicolas_S_feature" /locus_tag="new_2980988_2981070_c" /HighExp="T2.30H, M40t90, T1.0H, T-3.40H, HiOs, T3.30H, T3.0H, T0.0H, Lbstat, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1099" upshifts complement(2477842) /Source="Nicolas_upshifts" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="upshifts" S_feature complement(2477844..2477922) /Source="Nicolas_S_feature" /locus_tag="new_2981072_2981150_c" /HighExp="T2.30H, T3.30H, T1.0H, M40t90, T3.0H, Lbstat, M0t90, T0.0H, HiOs, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1100" promotor_-10 complement(2477844..2477863) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-10" promotor_-35 complement(2477879..2477883) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-35" CDS complement(2477923..2479041) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase II" /protein_id="NP_390792.1" /db_xref="EnsemblGenomes-Gn:BSU29140" /db_xref="EnsemblGenomes-Tr:CAB14874" /db_xref="GOA:P39120" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR011278" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG10855" /db_xref="UniProtKB/Swiss-Prot:P39120" /translation="MTATRGLEGVVATTSSVSSIIDDTLTYVGYDIDDLTENASFEEI IYLLWHLRLPNKKELEELKQQLAKEAAVPQEIIEHFKSYSLENVHPMAALRTAISLLG LLDSEADTMNPEANYRKAIRLQAKVPGLVAAFSRIRKGLEPVEPREDYGIAENFLYTL NGEEPSPIEVEAFNKALILHADHELNASTFTARVCVATLSDIYSGITAAIGALKGPLH GGANEGVMKMLTEIGEVENAEPYIRAKLEKKEKIMGFGHRVYKHGDPRAKHLKEMSKR LTNLTGESKWYEMSIRIEDIVTSEKKLPPNVDFYSASVYHSLGIDHDLFTPIFAVSRM SGWLAHILEQYDNNRLIRPRADYTGPDKQKFVPIEERA*" /label="citZ CDS" gene complement(2477923..2479041) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /label="citZ gene" downshifts 2478536 /Source="Nicolas_upshifts" /id="D1493" /incds=1 /nref=2 /ntot=63 /MaxReadThrough="1.41638" /MaxDrop="3.70762" /score="40.6931963" /energy="-9.9" /TU="NA" /idTUdmin="U2252" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" misc_feature 2478883..2478886 /Source="Nicolas_upshift_promotors" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2478891 /Source="Nicolas_upshifts" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2479020 /Source="Nicolas_upshifts" /id="D1494" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="2.98678" /MaxDrop="3.07929" /score="40.6931963" /energy="-9.9" /TU="U2252" /idTUdmin="U2252" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2479042..2479248) /Source="Nicolas_S_feature" /locus_tag="new_2982270_2982476_c" /HighExp="T3.0H, T3.30H, T2.30H, T4.0H, M0t90, T2.0H, T1.30H, T5.0H, BC, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1101" misc_feature 2479216..2479228 /Source="Nicolas_upshift_promotors" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2479227 /Source="Nicolas_upshifts" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2479234..2479253) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2479248) /Source="Nicolas_upshifts" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2479268..2479272) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2479368) /Source="Nicolas_upshifts" /id="D1495" /incds=0 /nref=116 /ntot=204 /MaxReadThrough="6.4946" /MaxDrop="5.00031" /score="29.3344463" /energy="-8.1" /TU="NA" /idTUdmin="U2255" /TUdmin=14 /isTUend="TRUE" /label="downshifts" CDS complement(2479375..2479839) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390793.1" /db_xref="EnsemblGenomes-Gn:BSU29150" /db_xref="EnsemblGenomes-Tr:CAB14875" /db_xref="GOA:O34811" /db_xref="InterPro:IPR007382" /db_xref="SubtiList:BG13933" /db_xref="UniProtKB/Swiss-Prot:O34811" /translation="MFTQANLFLILLLAIALIAKNQSLLFAVSVLLIIKIVGLDQKLF PTIQSKGINWGVTIITIAVLVPIATGEIGFKQLGEAMRSSYAWIALGAGIAVALIAKN GLTLLENDPHITTALVIGTILAVALFGGVAVGPLIGAGIAYLAMQIVKLFTS*" /label="ytwI CDS" gene complement(2479375..2479839) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /label="ytwI gene" promotor_-10 complement(2479852..2479871) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2479866) /Source="Nicolas_upshifts" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2479868..2481053) /Source="Nicolas_S_feature" /locus_tag="new_2983096_2984281_c" /HighExp="G135, G180, LBGstat, G150, LBGtran, S0, Paraq, Oxctl, H2O2, LBGexp" /AntisenseName="ytvI" /AntisenseCor="-0.73323145377324295" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1102" promotor_-35 2479868..2479873 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2479884..2479892) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2479888..2479906 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2479894 /Source="Nicolas_upshifts" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="upshifts" CDS 2479936..2481051 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12662922, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sporulation-related permease" /protein_id="NP_390794.1" /db_xref="EnsemblGenomes-Gn:BSU29160" /db_xref="EnsemblGenomes-Tr:CAB14876" /db_xref="GOA:O34991" /db_xref="InterPro:IPR002549" /db_xref="InterPro:IPR014227" /db_xref="SubtiList:BG13930" /db_xref="UniProtKB/Swiss-Prot:O34991" /translation="MNQSYITIFFRTLFVISMTAGSIAAAYYSFPLTYPFLIALILSS VIHPVVDYLDKVTGFPRTINVLGVLAFFLLAAFGVLTILVAEIVTGTAYLAKTLPPHI STFISYCEKLFTTHIQPLYNELTLLFQELETNQQASIVTHIQTLGDSAAKNAGLLLSH ILEMIPRFFALLPNTAAVLIFSLLATFFMTKDWHKLKAMLVLILPDRVTANSKAISSE LKKAMTGFIKAQAVLVFITMVIVFIGLSLLKVEHAATIAFLIGLVDLLPYLGAGSVFV PWILYLSITGQLPQAIGIGILYLVVLIQRQLTEPKILSKSIGIDPLATLIALFAGFKL FGFLGLIAGPAVLVIIQAFITTGALKEIWSYITVQQK*" /label="ytvI CDS" gene 2479936..2481051 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /label="ytvI gene" downshifts 2481022 /Source="Nicolas_upshifts" /id="D1496" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.639" /MaxDrop="3.31897" /score="37.6858539" /energy="-16.7" /TU="NA" /idTUdmin="U2256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2481084..2481467) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15302217, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390795.1" /db_xref="EnsemblGenomes-Gn:BSU29170" /db_xref="EnsemblGenomes-Tr:CAB14877" /db_xref="GOA:O32064" /db_xref="InterPro:IPR007313" /db_xref="SubtiList:BG13935" /db_xref="UniProtKB/Swiss-Prot:O32064" /translation="MRFLFLLFIVFPAIEIGIFLFLGNLIGILPTVLFMILTGIIGAA AAKKQGTEVYYKVQRDLQYGKMPGEAIADGLCIFIGGLLLMLPGFLSDLAGACLLIPF TRGWCKPILFKWLRGMSKNKRIIIK*" /label="ytzA CDS" gene complement(2481084..2481467) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /label="ytzA gene" downshifts complement(2481098) /Source="Nicolas_upshifts" /id="D1497" /incds=0 /nref=181 /ntot=256 /MaxReadThrough="4.28884" /MaxDrop="5.74703" /score="18.319512" /energy="-13.8" /TU="NA" /idTUdmin="U2257" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2481468..2481559) /Source="Nicolas_S_feature" /locus_tag="new_2984696_2984787_c" /HighExp="G135, LBGtran, G150, LBGexp, M0t45, Lbexp, S0, G180, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1103" CDS complement(2481560..2483317) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /EC_number="2.7.1.40" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate kinase" /protein_id="NP_390796.1" /db_xref="EnsemblGenomes-Gn:BSU29180" /db_xref="EnsemblGenomes-Tr:CAB14878" /db_xref="GOA:P80885" /db_xref="InterPro:IPR001697" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR011037" /db_xref="InterPro:IPR015793" /db_xref="InterPro:IPR015795" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018209" /db_xref="InterPro:IPR036918" /db_xref="SubtiList:BG12661" /db_xref="UniProtKB/Swiss-Prot:P80885" /translation="MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFEEHG ARIKNIREASKKLGKNVGILLDTKGPEIRTHTMENGGIELETGKELIISMDEVVGTTD KISVTYEGLVHDVEQGSTILLDDGLIGLEVLDVDAAKREIKTKVLNNGTLKNKKGVNV PGVSVNLPGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQII PKIENQEGVDNIDAILEVSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVIT ATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQTMHNIASR SEEALNYKEILSKRRDQVGMTITDAIGQSVAHTAINLNAAAIVTPTESGHTARMIAKY RPQAPIVAVTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDL IVITAGTVGESGTTNLMKVHTVGDIIAKGQGIGRKSAYGPVVVAQNAKEAEQKMTDGA VLVTKSTDRDMIASLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQ DITVDASRGAVYQGRASVL*" /label="pyk CDS" gene complement(2481560..2483317) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /label="pyk gene" CDS complement(2483360..2484319) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /EC_number="2.7.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12450869, 12622823, 12682299, 19193632, 20473954, 22198292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450869, 12622823, 12682299, 19193632, 20473954, 22198292; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phosphofructokinase" /protein_id="NP_390797.1" /db_xref="EnsemblGenomes-Gn:BSU29190" /db_xref="EnsemblGenomes-Tr:CAB14879" /db_xref="GOA:O34529" /db_xref="InterPro:IPR000023" /db_xref="InterPro:IPR012003" /db_xref="InterPro:IPR012828" /db_xref="InterPro:IPR015912" /db_xref="InterPro:IPR022953" /db_xref="InterPro:IPR035966" /db_xref="PDB:4A3S" /db_xref="SubtiList:BG12644" /db_xref="UniProtKB/Swiss-Prot:O34529" /translation="MKRIGVLTSGGDSPGMNAAVRAVVRKAIYHDVEVYGIYNGYAGL ISGKIEKLELGSVGDIIHRGGTKLYTARCPEFKTVEGREKGIANLKKLGIEGLVVIGG DGSYMGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSH ERTYVIEVMGRHAGDIALWAGLAGGAESILIPEADYDMHEIIARLKRGHERGKKHSII IVAEGVGSGVEFGKRIEEETNLETRVSVLGHIQRGGSPSAADRVLASRLGAYAVELLL EGKGGRCVGIQNNKLVDHDIIEILETKHTVEQNMYQLSKELSI*" /label="pfkA CDS" gene complement(2483360..2484319) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /label="pfkA gene" S_feature complement(2484320..2484421) /Source="Nicolas_S_feature" /locus_tag="new_2987548_2987649_c" /HighExp="G150, LBGtran, LBGexp, Lbexp, dia0, G180, G135, Oxctl, LBGstat, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1104" promotor_-10 complement(2484410..2484429) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2484421) /Source="Nicolas_upshifts" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2484445..2484449) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2484503..2485480) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase alpha subunit)" /protein_id="NP_390798.1" /db_xref="EnsemblGenomes-Gn:BSU29200" /db_xref="EnsemblGenomes-Tr:CAB14880" /db_xref="GOA:O34847" /db_xref="InterPro:IPR001095" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12557" /db_xref="UniProtKB/Swiss-Prot:O34847" /translation="MAPRLEFEKPVIELQTKIAELKKFTQDSDMDLSAEIERLEDRLA KLQDDIYKNLKPWDRVQIARLADRPTTLDYIEHLFTDFFECHGDRAYGDDEAIVGGIA KFHGLPVTVIGHQRGKDTKENLVRNFGMPHPEGYRKALRLMKQADKFNRPIICFIDTK GAYPGRAAEERGQSEAIAKNLFEMAGLRVPVICIVIGEGGSGGALGLGVGNHLHMLEN STYSVISPEGAAALLWKDSSLAKKAAETMKITAPDLKELGIIDHMIKEVKGGAHHDVK LQASYMDETLKQSLKTLLKLSEEELVQQRYEKYKAIGKVSVEDQYIGVN*" /label="accA CDS" gene complement(2484503..2485480) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /label="accA gene" downshifts complement(2484530) /Source="Nicolas_upshifts" /id="D1498" /incds=0 /nref=48 /ntot=176 /MaxReadThrough="5.40549" /MaxDrop="5.53933" /score="-3.96100458" /energy="-6.8" /TU="U2259,U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2485465..2486337) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /EC_number="6.4.1.2" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 14594796, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase betasubunit)" /protein_id="NP_390799.2" /db_xref="EnsemblGenomes-Gn:BSU29210" /db_xref="EnsemblGenomes-Tr:CAB14881" /db_xref="GOA:C0SP93" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13926" /db_xref="UniProtKB/Swiss-Prot:C0SP93" /translation="MLKDIFTKKKKYASVPSDQAKHDVPEGIMTKCPKCKKIMLTKEL DKNMRVCMNCDYHFPMNAKQRIESLMDEQSFEEFNQGMLSENPLGFPGYLEKLEKDRE KTSLNEAVVTGKGTIGGHPAVVAVMDSSFRMGSMGSVVGEKITLAIEKAKADKVPFII FTASGGARMQEGVLSLMQMAKTSSALKLFSEEQGLIISVMTHPTTGGVSASFASLGDY NFAEPGALIGFAGRRIIEQTIGEKLPEDFQTAEFLLKHGQLDAVIHRDDMKKTLENLL DMHQTGGDIEWLQD*" /label="accD CDS" gene complement(2485465..2486337) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /label="accD gene" promotor_-35 2486299..2486304 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2486320..2486338 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2486324..2487498 /Source="Nicolas_S_feature" /locus_tag="new_2989552_2990726" /HighExp="S5, S8, S6, S7, C30, S4, C90, S3, T5.0H, BC" /AntisenseName="ytsJ" /AntisenseCor="-0.46008986922877199" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1105" upshifts 2486324 /Source="Nicolas_upshifts" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2486338..2486421) /Source="Nicolas_S_feature" /locus_tag="new_2989566_2989649_c" /HighExp="LBGstat, T4.0H, LBGtran, T5.0H, C30, dia15, M9-stat, Oxctl, LBGexp, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1106" promotor_-10 complement(2486410..2486429) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2486421) /Source="Nicolas_upshifts" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2486423..2486575) /Source="Nicolas_S_feature" /locus_tag="new_2989651_2989803_c" /HighExp="Diami, BC, dia15, Sw, dia5, M40t90, H2O2, S2, G/S, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1107" promotor_-35 complement(2486445..2486449) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2486577..2486671) /Source="Nicolas_S_feature" /locus_tag="new_2989805_2989899_c" /HighExp="dia15, LBGtran, LBGstat, Diami, LoTm, C90, GM 120, MG 60, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1108" downshifts complement(2486620) /Source="Nicolas_upshifts" /id="D1499" /incds=0 /nref=52 /ntot=158 /MaxReadThrough="7.72399" /MaxDrop="4.5863" /score="-3.96100458" /energy="-6.8" /TU="U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-2178" /isTUend="FALSE" /label="downshifts" CDS complement(2486672..2487904) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /EC_number="1.1.1.40" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 22740702, 23136871, 24325460, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 22740702, 23136871, 24325460, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP-dependent malic enzyme (conversion of malate into pyruvate, anabolic)" /protein_id="NP_390800.1" /db_xref="EnsemblGenomes-Gn:BSU29220" /db_xref="EnsemblGenomes-Tr:CAB14882" /db_xref="GOA:O34962" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG13922" /db_xref="UniProtKB/Swiss-Prot:O34962" /translation="MSLREEALHLHKVNQGKLESKSKVEVRNAKDLSLAYSPGVAEPC KDIHEDINKVYDYTMKGNMVAVVTDGTAVLGLGNIGPEAALPVMEGKAVLFKSFAGVD AFPIALNTNDVDKIVETVKLLEPTFGGVNLEDIAAPNCFIIEERLKKETNIPVFHDDQ HGTAIVTVAGLVNALKLSGKSMSSIKVVANGAGAAGIAIIKLLHHYGVRDIVMCDSKG AIYEGRPNGMNDVKNEVAKFTNQDRKDGSLKDVIVDADVFIGVSVAGALTKEMVQSMA KDPIIFAMANPNPEIMPEDAREAGASVVGTGRSDFPNQVNNVLAFPGIFRGALDVRAT HINEEMKIAAVEAIASLVSEDELSADYVIPAPFDKRVAPAVAKAVAKAAMETGVARIT VDPEEVAEKTRKLTIIGE*" /label="maeB CDS" gene complement(2486672..2487904) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /label="maeB gene" S_feature complement(2487905..2488021) /Source="Nicolas_S_feature" /locus_tag="new_2991133_2991249_c" /HighExp="dia15, Diami, LBGstat, H2O2, LBGtran, dia5, M40t45, Lbtran, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1109" promotor_-10 complement(2488009..2488028) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2488021) /Source="Nicolas_upshifts" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" CDS complement(2488041..2491388) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit), DnaE3" /protein_id="NP_390801.1" /db_xref="EnsemblGenomes-Gn:BSU29230" /db_xref="EnsemblGenomes-Tr:CAB14883" /db_xref="GOA:O34623" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004805" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR029460" /db_xref="SubtiList:BG12583" /db_xref="UniProtKB/Swiss-Prot:O34623" /translation="MSFVHLQVHSGYSLLNSAAAVEELVSEADRLGYASLALTDDHVM YGAIQFYKACKARGINPIIGLTASVFTDDSELEAYPLVLLAKSNTGYQNLLKISSVLQ SKSKGGLKPKWLHSYREGIIAITPGEKGYIETLLEGGLFEQAAQASLEFQSIFGKGAF YFSYQPFKGNQVLSEQILKLSEETGIPVTATGDVHYIRKEDKAAYRCLKAIKAGEKLT DAPAEDLPDLDLKPLEEMQNIYREHPEALQASVEIAEQCRVDVSLGQTRLPSFPTPDG TSADDYLTDICMEGLRSRFGKPDERYLRRLQYELDVIKRMKFSDYFLIVWDFMKHAHE KGIVTGPGRGSAAGSLVAYVLYITDVDPIKHHLLFERFLNPERVSMPDIDIDFPDTRR DEVIQYVQQKYGAMHVAQIITFGTLAAKAALRDVGRVFGVSPKEADQLAKLIPSRPGM TLDEARQQSPQLDKRLRESSLLQQVYSIARKIEGLPRHASTHAAGVVLSEEPLTDVVP LQEGHEGIYLTQYAMDHLEDLGLLKMDFLGLRNLTLIESITSMIEKEENIKIDLSSIS YSDDKTFSLLSKGDTTGIFQLESAGMRSVLKRLKPSGLEDIVAVNALYRPGPMENIPL FIDRKHGRAPVHYPHEDLRSILEDTYGVIVYQEQIMMIASRMAGFSLGEADLLRRAVS KKKKEILDRERSHFVEGCLKKEYSVDTANEVYDLIVKFANYGFNRSHAVAYSMIGCQL AYLKAHYPLYFMCGLLTSVIGNEDKISQYLYEAKGSGIRILPPSVNKSSFPFTVENGS VRYSLRAIKSVGVSAVKDIYKARKEKPFEDLFDFCFRVPSKSVNRKMLEALIFSGAMD EFGQNRATLLASIDVALEHAELFAADDDQMGLFLDESFSIKPKYVETEELPLVDLLAF EKETLGIYFSNHPLSAFRKQLTAQGAVSILQAQRAVKRQLSLGVLLSKIKTIRTKTGQ NMAFLTLSDETGEMEAVVFPEQFRQLSPVLREGALLFTAGKCEVRQDKIQFIMSRAEL LEDMDAEKAPSVYIKIESSQHSQEILAKIKRILLEHKGETGVYLYYERQKQTIKLPES FHINADHQVLYRLKELLGQKNVVLKQW*" /label="dnaEC CDS" gene complement(2488041..2491388) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /label="dnaEC gene" promotor_-35 complement(2488042..2488049) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2489053..2489062 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2489074..2489089 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2489074 /Source="Nicolas_upshifts" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2489262..2489281) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2489281) /Source="Nicolas_upshifts" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2489295..2489302) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2491419..2491438) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2491437) /Source="Nicolas_upshifts" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" promotor_-35 complement(2491452..2491459) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2491477..2491482 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-35" upshifts 2491494 /Source="Nicolas_upshifts" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="upshifts" promotor_-10 2491498..2491516 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-10" CDS 2491528..2491869 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="membrane protein involved in a sporulation process" /protein_id="YP_003097771.1" /db_xref="EnsemblGenomes-Gn:BSU29239" /db_xref="EnsemblGenomes-Tr:CAX52677" /db_xref="GOA:C0H3P8" /db_xref="InterPro:IPR025689" /db_xref="UniProtKB/Swiss-Prot:C0H3P8" /translation="MDQEAGFMVNFINSYFIALGVLIGGALIGGLGAYLAGEPPLTAI TKLANRLKIWALVAAIGGTFDAVYSFERGILEGNTRDIFKQLLLIISAMGGAQSGWLI ISWLTQEHLSS*" /label="ytrH CDS" gene 2491528..2491869 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /label="ytrH gene" CDS 2491866..2492369 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="protein involved in sporulation" /protein_id="NP_390802.3" /db_xref="EnsemblGenomes-Gn:BSU29240" /db_xref="EnsemblGenomes-Tr:CAB14884" /db_xref="GOA:O34460" /db_xref="SubtiList:BG13917" /db_xref="UniProtKB/Swiss-Prot:O34460" /translation="MRVPQHYKKPGWQRFFAGMMCGAVISWFFFLFTYGTFQEEQVSL IEKQKEHVKDLNNQISIYQEDLHKLNEDNKRKLLIQSVSVKLLNGDKYKISQPDKTKF EEHVKDDISEVITKDIESVYQTKDLLKRTIENKVYMINEKKYEATVRELIIYTRLTVE LEISFAT*" /label="ytrI CDS" gene 2491866..2492369 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /label="ytrI gene" promotor_-35 2492402..2492405 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2492420..2492439 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2492420 /Source="Nicolas_upshifts" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" CDS 2492471..2492662 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative sporulation-related conserved protein" /protein_id="YP_003097772.1" /db_xref="EnsemblGenomes-Gn:BSU29249" /db_xref="EnsemblGenomes-Tr:CAX52678" /db_xref="UniProtKB/Swiss-Prot:C0H3P9" /translation="MEVYSDRQLAKDQAARLRQGFSAYAETNSLASLIKKELQSHNLQ VYEDLTDFGCWFIPVTDEH*" /label="ytzJ CDS" gene 2492471..2492662 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /label="ytzJ gene" downshifts complement(2492472) /Source="Nicolas_upshifts" /id="D1500" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.45109" /MaxDrop="3.19151" /score="-1.37123732" /energy="-6.5" /TU="NA" /idTUdmin="U2268" /TUdmin=220 /isTUend="FALSE" /label="downshifts" downshifts 2492638 /Source="Nicolas_upshifts" /id="D1501" /incds=0 /nref=15 /ntot=107 /MaxReadThrough="6.88261" /MaxDrop="6.74738" /score="-8.58003897" /energy="-4" /TU="U2265" /idTUdmin="U2264" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2492680..2493621) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /EC_number="3.1.3.7" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17586819, 19553197, 22102036, 26735940, 28894100" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17586819, 19553197, 22102036, 26735940, 28894100; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nanoRNase (oligoribonuclease) (3'->5'short substrates, 5'->3' long substrates), 3',5'-bisphosphate nucleotidase" /protein_id="NP_390803.1" /db_xref="EnsemblGenomes-Gn:BSU29250" /db_xref="EnsemblGenomes-Tr:CAB14885" /db_xref="GOA:O34600" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="PDB:5IPP" /db_xref="PDB:5IUF" /db_xref="PDB:5IZO" /db_xref="PDB:5J21" /db_xref="SubtiList:BG13910" /db_xref="UniProtKB/Swiss-Prot:O34600" /translation="MKTELIRTISLYDTIILHRHVRPDPDAYGSQCGLTEILRETYPE KNIFAVGTPEPSLSFLYSLDEVDNETYEGALVIVCDTANQERIDDQRYPSGAKLMKID HHPNEDPYGDLLWVDTSASSVSEMIYELYLEGKEHGWKLNTKAAELIYAGIVGDTGRF LFPNTTEKTLKYAGELIQYPFSSSELFNQLYETKLNVVKLNGFIFQNVSLSENGAASV FIKKDTLEKFGTTASEASQLVGTLGNISGIRAWVFFVEEDDQIRVRFRSKGPVINGLA RKYNGGGHPLASGASIYSWDEADRILADLETLCKEHE*" /label="nrnA CDS" gene complement(2492680..2493621) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /label="nrnA gene" S_feature 2492683..2493054 /Source="Nicolas_S_feature" /locus_tag="new_2995911_2996282" /HighExp="Lbstat, S2, M0t90, M40t90, nit, ferm, S3, BT, M9-stat, S0" /AntisenseName="nrnA" /AntisenseCor="-0.77648424268923499" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1110" downshifts complement(2492715) /Source="Nicolas_upshifts" /id="D1502" /incds=0 /nref=25 /ntot=163 /MaxReadThrough="3.12169" /MaxDrop="3.09205" /score="22.5196409" /energy="-7.9" /TU="U2268" /idTUdmin="U2269" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2493023..2493032 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2493046..2493065 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2493056..2493450 /Source="Nicolas_S_feature" /locus_tag="new_2996284_2996678" /HighExp="Lbstat, S2, S7, S8, S6, nit, ferm, M0t90, BT, M40t90" /AntisenseName="nrnA" /AntisenseCor="-0.85531073541330804" /AntisenseRegPval="-77.5" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1111" upshifts 2493056 /Source="Nicolas_upshifts" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2493412..2493418 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2493434..2493453 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2493452..2493751 /Source="Nicolas_S_feature" /locus_tag="new_2996680_2996979" /HighExp="Lbstat, S8, S7, S6, S2, Etha, nit, ferm, BT, M0t90" /AntisenseName="nrnA" /AntisenseCor="-0.84034645112995598" /AntisenseRegPval="-72.2" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1112" upshifts 2493452 /Source="Nicolas_upshifts" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2493640..2493659) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2493656) /Source="Nicolas_upshifts" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2493658..2494072) /Source="Nicolas_S_feature" /locus_tag="new_2996886_2997300_c" /HighExp="LBGtran, HiTm, G180, G135, G150, Lbtran, LBGexp, Mt0, Paraq, dia0" /AntisenseName="ytpI" /AntisenseCor="-0.70134306018551296" /AntisenseRegPval="-40.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1113" promotor_-35 complement(2493674..2493677) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2493752..2494054 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390804.1" /db_xref="EnsemblGenomes-Gn:BSU29260" /db_xref="EnsemblGenomes-Tr:CAB14886" /db_xref="GOA:O34922" /db_xref="InterPro:IPR025618" /db_xref="SubtiList:BG13902" /db_xref="UniProtKB/Swiss-Prot:O34922" /translation="MLVLVFLIGLSACFYVYYKVKGVRAKPSLAKEICSAKSSMALGS LVLFYGLNQMILFHSVLTLVIGGIFIVIGAGSAWAGYKAFRHYNPLHAKEAERDHA*" /label="ytpI CDS" gene 2493752..2494054 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /label="ytpI gene" S_feature 2494055..2495850 /Source="Nicolas_S_feature" /locus_tag="new_2997283_2999078" /HighExp="S8, S6, S7, Lbstat, B36, nit, ferm, T1.0H, C30, S5" /AntisenseName="ytoI" /AntisenseCor="-0.55304378374907204" /AntisenseRegPval="-22.2" /CDS_PredictionProba="0.89152299999999995" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1114" CDS complement(2494073..2495392) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26296725" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390805.1" /db_xref="EnsemblGenomes-Gn:BSU29270" /db_xref="EnsemblGenomes-Tr:CAB14887" /db_xref="GOA:O34921" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR010766" /db_xref="InterPro:IPR028979" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13897" /db_xref="UniProtKB/Swiss-Prot:O34921" /translation="MATKHEQILTYIDSLPVGEKISVRRIAKEMKVSEGTAYRAIKEA ENKGFVSTIERVGTIRIEQKKKENIEKLTYAEVVNVIDGQVLGGRAGLHKTLNKFVIG AMELDAMMRYTAAGNLLIVGNRINAHRQALEAGAAVLVTGGFNTDDSIVQLADELELP ILSTSYDTFTVAAMINRAIYDQLIKKEIVLVEDILTPADRTVYLSPKDKLEKWYEKNF ETGHGRFPVVDDQMKIHGILTSKDIAGHDRNASIEKVMTKNPVTVIGKTSVASAAQMM VWEGIEVLPVTDGHQKLIGMISRQDVLKALQMIQKQPQVGEKLDDIVSRGFKDEGDDK EDQTVYEYEVTPQMTNQLGTISYGVFTTILTQAANRFLRSKKRGELVIESITIFFLKP VQMESVIEVKPRILEAGRKFGKMEVEVHSQGHIVSKAMLMVQLMERS*" /label="ytoI CDS" gene complement(2494073..2495392) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /label="ytoI gene" promotor_-10 complement(2495418..2495437) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2495439) /Source="Nicolas_upshifts" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2495452..2495457) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2495568..2496470) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390806.1" /db_xref="EnsemblGenomes-Gn:BSU29280" /db_xref="EnsemblGenomes-Tr:CAB14888" /db_xref="GOA:O34430" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13894" /db_xref="UniProtKB/Swiss-Prot:O34430" /translation="MKKLIVFAFIGLLSQLIDGSLGMAYGVTSTSLLLAFGITPAVAS ASVHLAEVVTTAASGVSHIKFGNVDKQTVYQLVIPGSIGAFLGAAFLSQLPGDVAKPY ISLFLLLLGGYVLIRFLFQYKPALEKKHVPLNRKQSIPLGVIAGFADATGGGGWGPVT TPILLSRKGLSPRKVVGTVDTSEFAIAVSATAGFLISLGWEDVNWLWVFSLMAGGIIA APIAAWLVQKFHPQLMGVLVGGFIILVNARTLINEWIANTAVHPLIYTAIGAIWLSAV LFVLSKIGNRNIVKTAVDVHLKEK*" /label="ytnM CDS" gene complement(2495568..2496470) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /label="ytnM gene" CDS complement(2496489..2497739) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10588044, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10588044, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-alkyl-N-acetyl-metabolite deacetylase" /protein_id="NP_390807.1" /db_xref="EnsemblGenomes-Gn:BSU29290" /db_xref="EnsemblGenomes-Tr:CAB14889" /db_xref="GOA:O34980" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12596" /db_xref="UniProtKB/Swiss-Prot:O34980" /translation="MSLDYWRNIEGSYPYQTTGNDILTLKEESNPVNLSTLEKQLIGI RRHLHQYPELSKEEFETTAFIKKCLKEKGIQIRPTALKTGVFADIAGESEGPAIALRA DIDALPIEEKTGLPYASKHKGIMHACGHDFHTAALLGAAFLLKENQDSLKGKIRLLFQ PAEEAGAGATKVIEDGQLDGIDAVIGLHNKPDIAVGTVGLKTGPLMAAVDRFKVEIEG KGAHAALPHNGFDPIIGASQLIVALQTIVSRNVNPLQSAILTVGKINGGSTWNVIPDT VVIEGTVRTFDSEVRNQVKQRFFAVTEQISAAFSLKANVKWHSGPPPLCNDEAITGLV RDAAHKAKLQVIDPAPSTAGEDFAYYLEHIPGSFAFFGTDGDHDWHHPAFTIDETAII KASYFLYESAKRLLDSNEESKISD*" /label="sndA CDS" gene complement(2496489..2497739) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /label="sndA gene" CDS complement(2497757..2498449) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FMN-riboswitch-binding activator of rib genes" /protein_id="NP_390808.1" /db_xref="EnsemblGenomes-Gn:BSU29300" /db_xref="EnsemblGenomes-Tr:CAB14890" /db_xref="GOA:P94465" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11969" /db_xref="UniProtKB/Swiss-Prot:P94465" /translation="MTIIAGTVVKGKQLGRKLGFPTANVDAKIHGLRNGVYGVLATVN HQFHLGVMNIGVKPTVGSNLEKTLEIFLFDFHRDIYGEKIECSILFKIREERRFDSLE SLTKQIKKDISCVAKRFELIGIMAPNKKESLLSHQELNLPDLCFYKKCNNLYGVNRGV YNVIDNWFFEYGITQVAYRRIYILSFLSFLKEDNPKVSSKYIRFGAGGLADKLNRFIS SYVEESEENILG*" /label="ribR CDS" gene complement(2497757..2498449) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /label="ribR gene" CDS complement(2498496..2499824) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390809.1" /db_xref="EnsemblGenomes-Gn:BSU29310" /db_xref="EnsemblGenomes-Tr:CAB14891" /db_xref="GOA:O34974" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="PDB:1TVL" /db_xref="PDB:1YW1" /db_xref="SubtiList:BG13893" /db_xref="UniProtKB/Swiss-Prot:O34974" /translation="MTRADFIQFGAMIHGVGGTTDGWRHPDVDPSASTNIEFYMKKAQ TAEKGLFSFIFIADGLFISEKSIPHFLNRFEPITILSALASVTKNIGLVGTFSTSFTE PFTISRQLMSLDHISGGRAGWNLVTSPQEGAARNHSKSNLPEHTERYEIAQEHLDVVR GLWNSWEHDAFIHNKKTGQFFDQAKLHRLNHKGKYFQVEGPLNIGRSKQGEPVVFQAG SSETGRQFAAKNADAIFTHSNSLEETKAFYADVKSRAADEGRDPSSVRIFPGISPIVA DTEEEAEKKYREFAELIPIENAVTYLARFFDDYDLSVYPLDEPFPDIGDVGKNAFQST TDRIKREAKARNLTLREVAQEMAFPRTLFIGTPERVASLIETWFNAEAADGFIVGSDI PGTLDAFVEKVIPILQERGLYRQDYRGGTLRENLGLGIPQHQSVLHSSHH*" /label="cmoJ CDS" gene complement(2498496..2499824) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /label="cmoJ gene" CDS complement(2499821..2500102) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redoxin" /protein_id="NP_390810.1" /db_xref="EnsemblGenomes-Gn:BSU29320" /db_xref="EnsemblGenomes-Tr:CAB14892" /db_xref="GOA:O34639" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13892" /db_xref="UniProtKB/Swiss-Prot:O34639" /translation="MSDVVNIVVWSKKGCSYCEEVKNYLNEKGFPFQNIDVSEKEKLR DILQVKYGVRHVPVVEIGRGNQYQGITEIGIEHLDLALANHAQIKEAKR*" /label="cmoI CDS" gene complement(2499821..2500102) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /label="cmoI gene" CDS complement(2500117..2501121) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9836433, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9836433, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390811.1" /db_xref="EnsemblGenomes-Gn:BSU29330" /db_xref="EnsemblGenomes-Tr:CAB14893" /db_xref="GOA:O34846" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG13888" /db_xref="UniProtKB/Swiss-Prot:O34846" /translation="MIRLSILDQSLIGEGETAADTLQHTVKLAQMAEECGYHRFWVAE HHNNDEIAGSAPEVLLGYLAASTRKIRLASGGVMLQHYSSYKVAEQFHLLSALAPGRI DLGVGKAPGGFQLSTDALQAEYKKPVRQFDEKLEELTHFVRDDFPDTHRYAALRPRPQ VDRKPGIFLLGGSTESAISAAKLGISFVFAYFINGEEEVLKEARRAFDAHLPPGSEAE FHLAPAVFAAHTKEEAEKHIVSRESIKVVLKDGRKVNVGSREQAEAYLENVTEPYDII VQKTGIIAGTKEEVAEELTRLSGTYKINDFVIFTPIKNAVEKQLSYQLLSDAVLAAKR *" /label="cmoO CDS" gene complement(2500117..2501121) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /label="cmoO gene" CDS complement(2501118..2501897) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino-acid ABC transporter (ATP-binding protein)" /protein_id="NP_390812.1" /db_xref="EnsemblGenomes-Gn:BSU29340" /db_xref="EnsemblGenomes-Tr:CAB14894" /db_xref="GOA:O34900" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG12604" /db_xref="UniProtKB/Swiss-Prot:O34900" /translation="MIEIKNIHKQFGIHHVLKGINLTVRKGEVVTIIGPSGSGKTTFL RCLNLLERPDEGIISIHDKVINCRFPSKKEVHWLRKQTAMVFQQYHLFAHKTVIENVM EGLTIARKMRKQDAYAVAENELRKVGLQDKLNAYPSQLSGGQKQRVGIARALAIHPDV LLFDEPTAALDPELVGEVLEVMLEIVKTGATMIVVTHEMEFARRVSDQVVFMDEGVIV EQGTPEEVFRHTKKDRTRQFLRRVSPEYLFEPKEHIKEPVI*" /label="tcyN CDS" gene complement(2501118..2501897) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /label="tcyN gene" CDS complement(2501894..2502601) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390813.1" /db_xref="EnsemblGenomes-Gn:BSU29350" /db_xref="EnsemblGenomes-Tr:CAB14895" /db_xref="GOA:O34931" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13887" /db_xref="UniProtKB/Swiss-Prot:O34931" /translation="MQFDFPFIVSAMKEMVKTIPLTLMMAVLPIVFGFLVALGNIIVR IFRIKGLVACSRFYVSFFRSTPAILHIMLIYLGIPPVADQVSSFFHLGWSANEIPVSM FVIMALSLTAGAYLTEIIRSGILAMDTGQVEAAYSIGLTYSQTFRRVILPQALKVSIP NFTNLGIGFLHTTSIAAIVAVPEITGTATIVASDNYAFLEAFIGAAIIYWVLTLILES ANGVLERKAARFQGGTL*" /label="tcyM CDS" gene complement(2501894..2502601) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /label="tcyM gene" CDS complement(2502631..2503350) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390814.1" /db_xref="EnsemblGenomes-Gn:BSU29360" /db_xref="EnsemblGenomes-Tr:CAB14896" /db_xref="GOA:O34315" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13886" /db_xref="UniProtKB/Swiss-Prot:O34315" /translation="MEKAFDMNMIGDFVPTLTAYLPVTLYILTLSLLFGFVLGLFLAL PRIYNIPIVNQLAKVYISFFRGTPIMVQLFIVFYGIPALTGLIGIDTSKMDPFYAAVA TYALSNAAAAAEIIRAGVGSVDKGQTEAAYSIGLSGSQAFRRIVLPQALVQAFPNMGN MVISSLKDTSLAFSIGVMDMSGRGQTLITSSNHSLEVYIALSIVYYAVAVLFEWFFRV AEKRIKKNQTRIVTVFDMNIH*" /label="tcyL CDS" gene complement(2502631..2503350) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /label="tcyL gene" promotor_-35 2503176..2503183 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2503198..2503217 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2503198 /Source="Nicolas_upshifts" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2503372..2504184) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 22720735, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 22720735, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390815.1" /db_xref="EnsemblGenomes-Gn:BSU29370" /db_xref="EnsemblGenomes-Tr:CAB14897" /db_xref="GOA:O34852" /db_xref="InterPro:IPR001638" /db_xref="PDB:2O1M" /db_xref="SubtiList:BG13885" /db_xref="UniProtKB/Swiss-Prot:O34852" /translation="MKTKTAFMAILFSLITVLSACGAGSQTTGAGQKKVQTITVGTGT QFPNICFIDEKGDLTGYDVELIKELDKRLPHYKFTFKTMEFSNLLVSLGQHKVDIVAH QMEKSKEREKKFLFNKVAYNHFPLKITVLQNNDTIRGIEDLKGKRVITSATSNGALVL KKWNEDNGRPFEIAYEGQGANETANQLKSGRADATISTPFAVDFQNKTSTIKEKTVGN VLSNAKVYFMFNKNEQTLSDDIDKALQEIIDDGTLKRLSLKWLGDDYSKEQY*" /label="tcyK CDS" gene complement(2503372..2504184) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /label="tcyK gene" CDS complement(2504198..2505007) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390816.1" /db_xref="EnsemblGenomes-Gn:BSU29380" /db_xref="EnsemblGenomes-Tr:CAB14898" /db_xref="GOA:O34406" /db_xref="InterPro:IPR001638" /db_xref="SubtiList:BG13884" /db_xref="UniProtKB/Swiss-Prot:O34406" /translation="MNKRKGLVLLLSVFALLGGGCSQTNNKTDRQAQTVIVGTGTDFP NIAFLNEKGELTGYDIEVMKAIDKELPQYTFEFKTMDFSNLLTSLGNKKIDVIAHNMA KNKEREKRFLYHKVPYNYSPMYITVKEDNHKIHTLKDLHGKTVIVGATSNAADYITKY NKTHGSPIHLKYAGQGSNDTANQIETGRADATIATPFAVDFQNKTHAFRQKTVGDVLL DTEVYFMFNKGSQTLADDTDQAIKKLEKNGTLKKLSRKWLGADYSKSSFEK*" /label="tcyJ CDS" gene complement(2504198..2505007) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /label="tcyJ gene" CDS complement(2505021..2505557) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyltransferase acting on sulfur compounds" /protein_id="NP_390817.1" /db_xref="EnsemblGenomes-Gn:BSU29390" /db_xref="EnsemblGenomes-Tr:CAB14899" /db_xref="GOA:O34350" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13883" /db_xref="UniProtKB/Swiss-Prot:O34350" /translation="MSDDIFRLATVEDASELLKLVNSAFQPIRQLDIDWPSTRADIQM VSENIEHHSAIVLERDGKLISTITIRFPWESETPPSKYPFVWWFATLPEYKGQGAGSK LLTYVEEKVLRDMLKAPALTLGTSARKHPWLADMYRRRGYEVYFEQEKDGDIGVMMHK VLIPERFNPTLLGAPSWA*" /label="snaA CDS" gene complement(2505021..2505557) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /label="snaA gene" promotor_-35 2505594..2505601 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2505612..2505631) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2505615..2505634 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2505618..2505709 /Source="Nicolas_S_feature" /locus_tag="new_3008846_3008937" /HighExp="dia5, MG 5, UNK1, MG t5, MG 10, B60, dia0, nit, Diami, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1115" upshifts 2505618 /Source="Nicolas_upshifts" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2505628) /Source="Nicolas_upshifts" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2505645..2505652) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2505710..2506636 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of operon snaA-ytnM degrading cysteine-containing compounds (AscR-N-acetylcysteine)" /protein_id="NP_390818.1" /db_xref="EnsemblGenomes-Gn:BSU29400" /db_xref="EnsemblGenomes-Tr:CAB14900" /db_xref="GOA:O35038" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13877" /db_xref="UniProtKB/Swiss-Prot:O35038" /translation="MELRSIKTFHTIVKFGSFYKAAEILNYSQPTISMRMKQLEQDLG VLLFERGKSLQLTKAGKLFYERTGDLLMQYEALKHNLSDLKEEEAGIINIGVSEPTAS LIFPEILKDFLMDYPKITVNIKVDDANTCSQKLLDGTIDFAVCGEPELILENYYHPFF YDTLNVIVSDQHPLAEKKAVHLSDLAEERFIFTPANCPIRLQIEQHLHRELGNRYKKM ELTSSMSHEYYVRENIGISIFTSTAHSKPFNGTKVIPILNLDITPPIGLLTNQKEVHF DRATKDLIARITKRFQQRSKELEGTSDKTITG*" /label="ascR CDS" gene 2505710..2506636 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /label="ascR gene" S_feature complement(2506112..2506641) /Source="Nicolas_S_feature" /locus_tag="new_3009340_3009869_c" /HighExp="Etha, dia15, dia5, H2O2, M9-stat, M40t90, Sw, Gly, M0t90, Cold" /AntisenseName="ytlI" /AntisenseCor="-7.8012588423369304E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1116" downshifts complement(2506686) /Source="Nicolas_upshifts" /id="D1503" /incds=0 /nref=142 /ntot=251 /MaxReadThrough="4.32965" /MaxDrop="5.01142" /score="39.1547987" /energy="-16.5" /TU="U2273" /idTUdmin="U2274" /TUdmin=20 /isTUend="TRUE" /label="downshifts" CDS complement(2506687..2507370) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390819.2" /db_xref="EnsemblGenomes-Gn:BSU29410" /db_xref="EnsemblGenomes-Tr:CAB14901" /db_xref="GOA:Q795U4" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR022877" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13871" /db_xref="UniProtKB/Swiss-Prot:Q795U4" /translation="MKVTYHGHSVITVETKDHHIIFDPFLTGNSLTDIKPEDVKADVI LLTHGHNDHVGDTEQIAKQNNALVIAPNELAVYLGWKGLNVHPMHIGGSRQFDFGKVK LTQAFHGSAITDEENKTITYTGMPAGILLTVEDKTIFHAGDTALFSDMKLIGELNHID LAFLPIGDNFTMGPEDAKLAAEWLRAKQVVPVHYNTFPVIEQDPEAFADSLPGGVGKV MSVGETIEL*" /label="ytkL CDS" gene complement(2506687..2507370) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /label="ytkL gene" S_feature complement(2507371..2507432) /Source="Nicolas_S_feature" /locus_tag="new_3010599_3010660_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, M0t90, M40t90, Salt, LBGtran, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1117" CDS complement(2507433..2508200) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_390820.1" /db_xref="EnsemblGenomes-Gn:BSU29420" /db_xref="EnsemblGenomes-Tr:CAB14902" /db_xref="GOA:O34308" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13870" /db_xref="UniProtKB/Swiss-Prot:O34308" /translation="MRHALITAGSKGLGRKVTETLLAKGYSVTVNYRQDEEAVSRLKE ACPDCLDRLQFVKGDVTKKEDLLRIAEAALNRFGRIDFLINNAGPYIFERKKLADYTD DEWYGMLEGNLSAVFHLFKAVIPIMRKQQFGRIITYGFQGAAHAPGWLHRSAFGAAKV GLASLTKTIAIEEAEFGITANMVCPGDIVGDMKEASIEEARMRIGKEKTPIGRSGTGE DIARIIAFLCEENSDLVTGTVIEATGGLNVINKNQTT*" /label="ytkK CDS" gene complement(2507433..2508200) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /label="ytkK gene" promotor_-10 complement(2508245..2508264) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2508267) /Source="Nicolas_upshifts" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2508280..2508282) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2508327..2508563) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11423008" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390821.3" /db_xref="EnsemblGenomes-Gn:BSU29430" /db_xref="EnsemblGenomes-Tr:CAB14903" /db_xref="SubtiList:BG13938" /db_xref="UniProtKB/Swiss-Prot:O34503" /translation="MKKRKLAWQQEFVKISFIKSRHYSQPTSIMMGGRMMKKEPERYI YDEQESQETTRLISEAYQSGYVDMPDQESSSPAE*" /label="ytzD CDS" gene complement(2508327..2508563) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /label="ytzD gene" downshifts 2508412 /Source="Nicolas_upshifts" /id="D1504" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="0.55049" /MaxDrop="4.17437" /score="-5.88070891" /energy="-8.9" /TU="NA" /idTUdmin="U2271" /TUdmin=1782 /isTUend="FALSE" /label="downshifts" downshifts complement(2508432) /Source="Nicolas_upshifts" /id="D1505" /incds=0 /nref=199 /ntot=288 /MaxReadThrough="5.44889" /MaxDrop="6.29233" /score="21.2322542" /energy="-8.5" /TU="U2274" /idTUdmin="U2274" /TUdmin="-1726" /isTUend="FALSE" /label="downshifts" CDS complement(2508523..2509908) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /EC_number="4.3.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 9890879, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 9890879, 11423008; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate lyase" /protein_id="NP_390822.1" /db_xref="EnsemblGenomes-Gn:BSU29440" /db_xref="EnsemblGenomes-Tr:CAB14904" /db_xref="GOA:O34858" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR009049" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="InterPro:IPR029419" /db_xref="SubtiList:BG12571" /db_xref="UniProtKB/Swiss-Prot:O34858" /translation="MKKLWGGRFQKTPEKWVDEFGASISFDQNLVAEDITGSLAHAAM LKKCGILTAEEELKIREGLNTLLQKAEEGALEFSVDYEDIHLNIEKMLIDEIGPLGGK LHTGRSRNDQVATDMHLYLKNHVGHIIELIEAFQSALIEKAEANVETILPGYTHLQRA QPISFAHHLLAYFWMLERDKERFQDSMKRINKSPLGCGALAGTTFPIDRDYSAELLGF DAIYENSLDGVSDRDFILEFLSNSSMLMMHLSRFSEEIILWCSQEFKFIELDDTYATG SSMMPQKKNPDMAELIRGKTGRVYGDMMGLFTIMKGLPLAYNKDLQEDKEGMFDTVKT VEGSLQIFTGMIQTMTVNKDVMKQATKQDFSNATELADYLAKKGMPFREAHEVVGKLV YTCIERGIYLSDMPFGEFQQASTLFEEDIYTVLDPYYAVEKRMSAGGTGFKQVEQALE KAKACVAAGVC*" /label="argH CDS" gene complement(2508523..2509908) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /label="argH gene" CDS complement(2509905..2511116) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /EC_number="6.3.4.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 11423008, 12963366, 17611193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 11423008, 12963366, 17611193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate synthase" /protein_id="NP_390823.1" /db_xref="EnsemblGenomes-Gn:BSU29450" /db_xref="EnsemblGenomes-Tr:CAB14905" /db_xref="GOA:O34347" /db_xref="InterPro:IPR001518" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018223" /db_xref="InterPro:IPR023434" /db_xref="InterPro:IPR024074" /db_xref="SubtiList:BG12570" /db_xref="UniProtKB/Swiss-Prot:O34347" /translation="MSEQKKVVLAYSGGLDTSVAIKWLQEQGYNVIACCLDVGEGKDL AFVQQKALEVGATNSYVIDAKEEFAQDYALISLQAHTMYEGKYPLVSALSRPLIAKKL VEIAEKEDAQAIAHGCTGKGNDQVRFEVSIKSLNPDLEVIAPVREWQWSREEEIEYAA SRGIPIPINLDSPYSIDQNLWGRANECGILEDPWAAPPEGAYDLTAPLEKTPDTPEVI EIAFEQGVPVSIDGVSYSLSELILKLNEMAGAHGVGRIDHVENRLVGIKSREVYECPG AMTLIKAHKELEDLTLVKEVAHFKPIIEQKMSEIIYNGLWFSPLKDALHAFLKETQKH VTGIVRVKLFKGHAIVEGRKSEYSLYDEKLATYTKDDAFDHHAAIGFIELWGLPTKVN SIVKKKEQIKA*" /label="argG CDS" gene complement(2509905..2511116) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /label="argG gene" S_feature complement(2511117..2511194) /Source="Nicolas_S_feature" /locus_tag="new_3014345_3014422_c" /HighExp="S1, MG 15, T3.0H, T3.30H, T4.0H, T5.0H, BMM, T2.30H, T-0.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1118" promotor_-10 complement(2511187..2511206) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2511193) /Source="Nicolas_upshifts" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2511221..2511228) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2511286..2511798) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15269205, 20054111, 23680484; Product type f: factor" /codon_start=1 /transl_table=11 /product="molybdopterin GTP-binding precursor Z biosynthesis component" /protein_id="NP_390824.1" /db_xref="EnsemblGenomes-Gn:BSU29460" /db_xref="EnsemblGenomes-Tr:CAB14924" /db_xref="GOA:O34457" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008284" /db_xref="InterPro:IPR012245" /db_xref="InterPro:IPR036425" /db_xref="SubtiList:BG12618" /db_xref="UniProtKB/Swiss-Prot:O34457" /translation="MSVQEHKQEAPDIVRCKVITVSDTRTDETDKSGKLMISFLEEAG HHIAAYEIVKDEKDALQRSVLAGCMDEQTDAVLLNGGTGIADRDVTIEAITPLFSKEL PGFGEIFRMLSYTEDIGSAAIMSRATAGVIQHTAVFSTPGSSGAVKLAMNKLIIPELA HVVREIRKDK*" /label="moaB CDS" gene complement(2511286..2511798) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /label="moaB gene" downshifts complement(2511304) /Source="Nicolas_upshifts" /id="D1506" /incds=0 /nref=122 /ntot=221 /MaxReadThrough="1.48097" /MaxDrop="4.78155" /score="25.7910606" /energy="-10.8" /TU="NA" /idTUdmin="U2275" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2511824..2511843) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2511832) /Source="Nicolas_upshifts" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2511857..2511864) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2511883..2513070) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /EC_number="2.7.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8226682, 9811655, 11244084, 16995897, 19019159, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226682, 9811655, 11244084, 16995897, 19019159, 26098117; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetate kinase" /protein_id="NP_390825.1" /db_xref="EnsemblGenomes-Gn:BSU29470" /db_xref="EnsemblGenomes-Tr:CAB14925" /db_xref="GOA:P37877" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR004372" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG10813" /db_xref="UniProtKB/Swiss-Prot:P37877" /translation="MSKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTI SVNGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKDLNEIDGIGHRVVHGGEKFSDSVL LTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLY SLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEG GKSIDTSMGFTPLAGVAMGTRSGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGIS GFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGVDAIIFTAGIGENS VEVRERVLRGLEFMGVYWDPALNNVRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVR LAK*" /label="ackA CDS" gene complement(2511883..2513070) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /label="ackA gene" downshifts complement(2511898) /Source="Nicolas_upshifts" /id="D1507" /incds=0 /nref=13 /ntot=117 /MaxReadThrough="5.03131" /MaxDrop="3.1641" /score="19.2403206" /energy="-9.9" /TU="U2276" /idTUdmin="U2277" /TUdmin=242 /isTUend="FALSE" /label="downshifts" S_feature complement(2513071..2513175) /Source="Nicolas_S_feature" /locus_tag="new_3016299_3016403_c" /HighExp="dia0, Lbexp, LBGtran, Oxctl, LPh, M0t45, HPh, Paraq, H2O2, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1119" promotor_-10 complement(2513160..2513179) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2513175) /Source="Nicolas_upshifts" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2513177..2513306) /Source="Nicolas_S_feature" /locus_tag="new_3016405_3016534_c" /HighExp="S5, S6, S7, S8, S4, dia5, BT, H2O2, dia15, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1120" promotor_-35 complement(2513195..2513199) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2513243..2513446) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513997.1" /translation="MMNGLKKKSKCFKSSLDSRMRSMPKLLLFMLLKTGLDELNPALK HKIQREKPQIVSVHQYKTYSECV*" /label="hypothetical protein CDS" gene complement(2513243..2513446) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /label="gene" promotor_-10 complement(2513304..2513315) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2513306) /Source="Nicolas_upshifts" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2513330..2513336) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2513418..2514407) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid methyltransferase" /protein_id="NP_390826.1" /db_xref="EnsemblGenomes-Gn:BSU29480" /db_xref="EnsemblGenomes-Tr:CAB14926" /db_xref="GOA:P37876" /db_xref="InterPro:IPR003356" /db_xref="InterPro:IPR016843" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10812" /db_xref="UniProtKB/Swiss-Prot:P37876" /translation="MQKDHVGAVYELLNEAAIMIKNELQISYIEALAEAGEMYFLEKT DQLKLPADQKTKQLQALLEKAEFGTYEHEWVRKAFQLAVLKGMKDISHPNRQMTPDTI GLFISYLVNKFMADKKELTILDPALGTGNLLFTVLNQLSEKTANSFGIEIDDVLLKIA YAQANLLKKELELFHQDSLEPLFIDPVDTVICDLPVGYYPNDEGAEAFELKADEGHSF AHHLFIEQSVKHTKPGGYLFFMIPNHLFESSQSGKLKQFFKDKVHINALLQLPKSIFK DEAHAKSILVLQKQGENTKAPGQILLANLPSFSNQKAMLDMMAQFDEWFKKEK*" /label="ytxK CDS" gene complement(2513418..2514407) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /label="ytxK gene" downshifts complement(2513436) /Source="Nicolas_upshifts" /id="D1508" /incds=0 /nref=158 /ntot=243 /MaxReadThrough="3.51469" /MaxDrop="5.25938" /score="-4.33730173" /energy="-13.3" /TU="NA" /idTUdmin="U2279" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2514468..2514971) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486061, 18588855, 18588855, 23899494, 25355936, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486061, 18588855, 18588855, 23899494, 25355936, 25852656; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol peroxidase (lipid hydroperoxide reductase)" /protein_id="NP_390827.1" /db_xref="EnsemblGenomes-Gn:BSU29490" /db_xref="EnsemblGenomes-Tr:CAB14927" /db_xref="GOA:P80864" /db_xref="InterPro:IPR002065" /db_xref="InterPro:IPR013740" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR018219" /db_xref="InterPro:IPR036249" /db_xref="PDB:2JSY" /db_xref="PDB:2JSZ" /db_xref="SubtiList:BG13855" /db_xref="UniProtKB/Swiss-Prot:P80864" /translation="MAEITFKGGPVTLVGQEVKVGDQAPDFTVLTNSLEEKSLADMKG KVTIISVIPSIDTGVCDAQTRRFNEEAAKLGDVNVYTISADLPFAQARWCGANGIDKV ETLSDHRDMSFGEAFGVYIKELRLLARSVFVLDENGKVVYAEYVSEATNHPNYEKPIE AAKALVK*" /label="tpx CDS" gene complement(2514468..2514971) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /label="tpx gene" downshifts complement(2514474) /Source="Nicolas_upshifts" /id="D1509" /incds=0 /nref=53 /ntot=241 /MaxReadThrough="6.94509" /MaxDrop="4.3179" /score="9.29337297" /energy="-10.1" /TU="U2279" /idTUdmin="U2280" /TUdmin=548 /isTUend="FALSE" /label="downshifts" promotor_no_box 2514688..2514788 /Source="Nicolas_upshift_promotors" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2514748 /Source="Nicolas_upshifts" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2514967 /Source="Nicolas_upshifts" /id="D1510" /incds=0 /nref=86 /ntot=184 /MaxReadThrough="2.23568" /MaxDrop="5.49495" /score="20.1242958" /energy="-12.7" /TU="NA" /idTUdmin="U2278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2514994..2515013) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2515010) /Source="Nicolas_upshifts" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2515027..2515034) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2515081..2515536) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /experiment="publication(s) with functional evidences, PMID:23921501, 25790435, 27881417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23921501, 25790435, 27881417; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination-associated protein" /protein_id="NP_390828.1" /db_xref="EnsemblGenomes-Gn:BSU29500" /db_xref="EnsemblGenomes-Tr:CAB14928" /db_xref="GOA:O34806" /db_xref="InterPro:IPR014229" /db_xref="SubtiList:BG13849" /db_xref="UniProtKB/Swiss-Prot:O34806" /translation="MADHPIQGLMKTAMENLKEMIDVNTIIGDPVETPDGSVILTVSK VGFGFAAGGSEFGGKPAEKKSEDDETREQKLPFGGGSGGGVSITPIAFLIVGSTGIRM LHLDENTHLIEKILDAAPQTLERIQQMFKKNNKNQSQGQNQNQMNNMNY*" /label="gerW CDS" gene complement(2515081..2515536) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /label="gerW gene" downshifts complement(2515109) /Source="Nicolas_upshifts" /id="D1511" /incds=0 /nref=38 /ntot=91 /MaxReadThrough="3.69502" /MaxDrop="5.65648" /score="26.1939476" /energy="-12.7" /TU="U2280" /idTUdmin="U2280" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" CDS complement(2515550..2516230) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390829.1" /db_xref="EnsemblGenomes-Gn:BSU29510" /db_xref="EnsemblGenomes-Tr:CAB14929" /db_xref="InterPro:IPR021338" /db_xref="SubtiList:BG13848" /db_xref="UniProtKB/Swiss-Prot:O34917" /translation="MVYVLTAILILIGIVLLLRMKIHVALEYLHADDNDKLTLKITAL FGLIRIKKTIPAIKVNKEDGTVDIKQKTESKMKKSSGKKKITQNDVQQSINKIEMLLH QVTRLRKISASFLAHLHITKLEWVTVIGIQDAAVTGVLTGAVWGVKGGIAAMLYDHLD FVNKPVYEVIPSFQVPVSKTHFQCIFFFRFGHAMLAAFKFVKYGRELSVLKKNPSARM TSKNDSSV*" /label="ytfI CDS" gene complement(2515550..2516230) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /label="ytfI gene" upshifts complement(2515642) /Source="Nicolas_upshifts" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="upshifts" promotor_-10 complement(2515649..2515660) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-10" promotor_-35 complement(2515675..2515681) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-35" downshifts complement(2515968) /Source="Nicolas_upshifts" /id="D1512" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.64036" /MaxDrop="2.98792" /score="28.0381876" /energy="-11.8" /TU="U2281" /idTUdmin="U2281" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2516243..2516261) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-10" upshifts complement(2516257) /Source="Nicolas_upshifts" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="upshifts" promotor_-35 complement(2516276..2516281) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-35" CDS complement(2516305..2516799) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390830.1" /db_xref="EnsemblGenomes-Gn:BSU29520" /db_xref="EnsemblGenomes-Tr:CAB14930" /db_xref="GOA:O34424" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG13840" /db_xref="UniProtKB/Swiss-Prot:O34424" /translation="MDATYEELERNDIKGPQEAELLTHAYAGFWVRFWAFLLDWLVIW GLNHLLVSPLFTVLDLPKTSGMFTFSAYSVTTLIVYLAYFALMTKYFRQTLGKMVFGL KVVSVKQDSKLTWSTVIFREVVGRYIDKIWILYIVVAFSPTKQGIHDYIADTTVVHEK LYRK*" /label="yteJ CDS" gene complement(2516305..2516799) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /label="yteJ gene" downshifts complement(2516320) /Source="Nicolas_upshifts" /id="D1513" /incds=0 /nref=240 /ntot=258 /MaxReadThrough="1.43721" /MaxDrop="6.8315" /score="28.0381876" /energy="-11.8" /TU="NA" /idTUdmin="U2282" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2516812..2517819) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9987136, 10455123, 16484219, 22472423, 23155385, 24228759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 10455123, 16484219, 22472423, 23155385, 24228759; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="signal peptide peptidase" /protein_id="NP_390831.1" /db_xref="EnsemblGenomes-Gn:BSU29530" /db_xref="EnsemblGenomes-Tr:CAB14931" /db_xref="GOA:O34525" /db_xref="InterPro:IPR002142" /db_xref="InterPro:IPR004635" /db_xref="InterPro:IPR029045" /db_xref="PDB:3RST" /db_xref="PDB:4KWB" /db_xref="SubtiList:BG13839" /db_xref="UniProtKB/Swiss-Prot:O34525" /translation="MNAKRWIALVIALGIFGVSIIVSISMSFFESVKGAQTDLTSLTD ESQEKTLENGSPSSKIAVLEVSGTIQDNGDSSSLLGADGYNHRTFLKNLERAKDDKTV KGIVLKVNSPGGGVYESAEIHKKLEEIKKETKKPIYVSMGSMAASGGYYISTAADKIF ATPETLTGSLGVIMESVNYSKLADKLGISFETIKSGAHKDIMSPSREMTKEEKNIMQS MVDNSYEGFVDVISKGRGMPKAEVKKIADGRVYDGRQAKKLNLVDELGFYDDTITAMK KDHKDLKNASVISYEESFGLGSLFSMGANKMFKSEIDFLNMREILSQSGSPRMMYLYA K*" /label="sppA CDS" gene complement(2516812..2517819) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /label="sppA gene" promotor_-10 complement(2517843..2517858) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2517860) /Source="Nicolas_upshifts" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2517862..2517941) /Source="Nicolas_S_feature" /locus_tag="new_3021090_3021169_c" /HighExp="LBGexp, Oxctl, LBGtran, dia0, H2O2, dia15, G180, G150, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1121" promotor_-35 complement(2517870..2517879) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2517919..2517938 /Source="Nicolas_upshift_promotors" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2517929 /Source="Nicolas_upshifts" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2517934..2517953) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2517938..2518004 /Source="Nicolas_S_feature" /locus_tag="new_3021166_3021232" /HighExp="M0t90, Sw, M9-stat, BC, M40t90, T4.0H, T2.30H, S1, T3.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1122" upshifts complement(2517941) /Source="Nicolas_upshifts" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2517969..2517973) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2518005..2518808 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /EC_number="2.7.1.23" /function="16.7: Manage energy" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897004, 16233726, 16511117, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase" /protein_id="NP_390832.1" /db_xref="EnsemblGenomes-Gn:BSU29540" /db_xref="EnsemblGenomes-Tr:CAB14932" /db_xref="GOA:O34934" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13837" /db_xref="UniProtKB/Swiss-Prot:O34934" /translation="MTDQRRNVYFFHKQDQETNEQARSLTQLAEEHGFTVVNQHSDAN IIASIGGDGTFLQAVRKTNFRDDCLYVGITKKGKAHLYCDFHSDEREKMVDAMTFEQI EVRKYPLIEVTVDQASPFHCLNEVSIRSSIIKTFVMDVLIDDLHFETFRGDGMIISTP TGSTAYNKSVAGAVVDPLLPCMQVSELASLNNNTYRTLGSPFVLSSDRKLTLRVVQDG NEHPIIGLDNEALSTRNVKTIEIKLSNKKIKTVKLKDNSFWEKVKRTFL*" /label="ppnKB CDS" gene 2518005..2518808 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /label="ppnKB gene" downshifts 2518738 /Source="Nicolas_upshifts" /id="D1514" /incds=1 /nref=46 /ntot=222 /MaxReadThrough="5.39036" /MaxDrop="3.90238" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-124" /isTUend="FALSE" /label="downshifts" downshifts 2518796 /Source="Nicolas_upshifts" /id="D1515" /incds=0 /nref=6 /ntot=54 /MaxReadThrough="3.14676" /MaxDrop="4.64552" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2518840..2520429) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19433221, 20386924, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-substituted formamide deformylase, dihydropyrimidinase or isoaspartyl peptidase" /protein_id="NP_390833.1" /db_xref="EnsemblGenomes-Gn:BSU29550" /db_xref="EnsemblGenomes-Tr:CAB14933" /db_xref="GOA:O34355" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR013108" /db_xref="InterPro:IPR032466" /db_xref="InterPro:IPR033932" /db_xref="SubtiList:BG13835" /db_xref="UniProtKB/Swiss-Prot:O34355" /translation="MKAIWHGGFIYTMLEEGDRTEAVYVEDGVIKGTGSYERLKEKYG SPETEEISLNGAVMFPGFVDSHLHLIGHGEKQLQLDLSALTSKDSILQAAKERERQLP KNDWLIGEGWNENQFETPDYLTKHDLDRLFPDRPVLLKRICRHAIAVNSAALQAAGIS RNTPDPDGGVIVKDANGEPTGLLFDKAQDLILKAVPPVSQHYVDEALTAAIKDCWTKG LTGGHSEDLSYYGDVSVPMKAYEKAAAGGKYPFRCHLLVHHEAVDRWEQLEKLSGPYV EFGAMKIFADGALGGRTALLKEPYQDDPSTNGVQVHDDETLGRLIRKAREKGMEVAVH AIGDLAFEKVLNAIEKHPPKNGRHDRLIHAQVLDNELIERAARMPIALDLQPHFVASD FPWVIDRLGKDRMKTAFAWKTLISKGILCAGGSDAPIEPVDPLLGIQSAVLRKSSHEQ NGPSYNESECLPVYEAIKLYTEGSAGIIYKEKSRGKIAEGYDADFTVLSGDPFAIDPA QLHLLEIKKTVINGQIVYEKS*" /label="ytcJ CDS" gene complement(2518840..2520429) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /label="ytcJ gene" downshifts complement(2518849) /Source="Nicolas_upshifts" /id="D1516" /incds=0 /nref=149 /ntot=255 /MaxReadThrough="2.61299" /MaxDrop="5.92403" /score="32.0110789" /energy="-13.8" /TU="NA" /idTUdmin="U2285" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2520449..2522038) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /EC_number="6.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-coenzyme A synthetase" /protein_id="NP_390834.2" /db_xref="EnsemblGenomes-Gn:BSU29560" /db_xref="EnsemblGenomes-Tr:CAB14934" /db_xref="GOA:C0SPB0" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13834" /db_xref="UniProtKB/Swiss-Prot:C0SPB0" /translation="MLKREDLIAPVQYNLVNEMEKFSAAGQKTALLWEDESGKQESWS YEKLMEETNKIGAALADLGFKKGDKLIVMVPRVLEAYAVYLAILKSGMVVIPCSEMLR AKDLEYRIEHAEVKGAIVYSEFIGAFRDVSTADKLITLSIGENDAGWKNLLSIEADGS QFKTADTTRDDMAFLSYTSGTTGQPKGVVHTHGWAFAHLKTSAGAWLDISEKDIVWAT AAPGWQKWVWSPFLAVLGSGATGFVYHGRFKAEKYLELLNRYKINVFCCTPTEYRLMA KVEGLKRFDLSALHSAVSAGEPLNREVIDVFQKHFGIKVRDGYGQTESTLLVGVLKDT PIKPGSMGKPTPGNQVEIINEDGEICKPGEVGDIAVHLSTPALFKEYFKDPERMKTQI RGDYFLTGDRARKDEEGYFWFESRNDDIIISSGYTIGPFEVEDALVKHPEVKECAVVA SPDEIRGSIVKAYVVLQNHEKRSDELVKMLQNHVKTITAPYKYPREIEFVESLPKTAS AKIRRVELRKREEQLKANKKA*" /label="ytcI CDS" gene complement(2520449..2522038) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /label="ytcI gene" promotor_-10 complement(2522084..2522101) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2522089) /Source="Nicolas_upshifts" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2522117..2522123) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2522216) /Source="Nicolas_upshifts" /id="D1517" /incds=0 /nref=242 /ntot=266 /MaxReadThrough="2.32229" /MaxDrop="9.17935" /score="30.5720337" /energy="-13.3" /TU="NA" /idTUdmin="U2287" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2522217..2522426) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:2456528, 2468649, 3009398, 16707666" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2456528, 2468649, 3009398, 16707666; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha-type SASP)" /protein_id="NP_390835.1" /db_xref="EnsemblGenomes-Gn:BSU29570" /db_xref="EnsemblGenomes-Tr:CAB14935" /db_xref="GOA:P04831" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10786" /db_xref="UniProtKB/Swiss-Prot:P04831" /translation="MANNNSGNSNNLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRA NGSVGGEITKRLVSFAQQNMGGGQF*" /label="sspA CDS" gene complement(2522217..2522426) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /label="sspA gene" promotor_-35 2522422..2522426 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2522426 /Source="Nicolas_upshifts" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2522435..2522449 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2522447..2522458) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2522458) /Source="Nicolas_upshifts" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2522473..2522479) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2522520..2523725) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /EC_number="2.8.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14757766, 16343540, 22773787, 24705700, 28287455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14757766, 16343540, 22773787, 24705700, 28287455; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="persulfide ATP pyrophosphatase involved in tRNA modification" /protein_id="NP_390836.2" /db_xref="EnsemblGenomes-Gn:BSU29580" /db_xref="EnsemblGenomes-Tr:CAB14936" /db_xref="GOA:O34595" /db_xref="InterPro:IPR003720" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020536" /db_xref="SubtiList:BG13827" /db_xref="UniProtKB/Swiss-Prot:O34595" /translation="MNYDHILIRFGEISTKGKNRKSFIERLKQNIRLVLKDYPNLKYF SNRDRMTITLNGEDPEALFPHLKQVFGIQSFSLAIKCDSRLDDIKATALKAIKDQYKP GDTFKVATKRAYKQFELDTNQMNAEIGGHILRNTEGLTVDVRNPDIPLRIEIREEATF LTIRDEKGAGGLPVGSAGKAMLMLSGGFDSPVAGFYAMKRGLSVEAVHFFSPPYTSER AKQKVMDLAKCLSRFGGSMTLHIVPFTKTQELIQKQIPENYTMTATRRLMLQIADRIR EKRNGLAIITGESLGQVASQTLESMYAINAVTSTPILRPLIAMDKTEIIEKSREIGTY ETSIQPFEDCCTIFTPPSPKTRPKKEKIEHFESFVDFEPYIQEAVDNIETMTLYSEQE ANDKFAELF*" /label="trmG CDS" gene complement(2522520..2523725) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /label="trmG gene" CDS complement(2523729..2524874) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_390837.1" /db_xref="EnsemblGenomes-Gn:BSU29590" /db_xref="EnsemblGenomes-Tr:CAB14937" /db_xref="GOA:O34874" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="SubtiList:BG12632" /db_xref="UniProtKB/Swiss-Prot:O34874" /translation="MIYLDNSSTTKPYDEVLNVYEQTSSRYFGNPSSLHRYGAETEQL LQAAKNQIKRSLGLKKYDIVFTSGATEANNAALKGAALSKIKTGKHIIATSIEHPSVT ESLEQLKELFGFDITYLSVNEDGFVSIEDLKAAIRPDTVLVSMMHVNNEVGSVQPIEA AGEVLKEHSNILFHVDYVQGIYKVPLAIEKAGIDLCSISGHKFHGLKGTGALIVKEGT RLIPLITGGSQQKGIRAGTEHTAGAVSLAKAINLASADFDTRLDTMTAVKELFMNRLS EIEGVVINTPQMNSAPHIINFSVPGIKAEVLLHMLEEQDIFVSTTSACSAKEHKPSKV LLEMGKGEQIAGSSIRISLNYSQTSDVAEPFMNALRPGIKKLREMMR*" /label="iscSB CDS" gene complement(2523729..2524874) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /label="iscSB gene" S_feature complement(2524875..2526018) /Source="Nicolas_S_feature" /locus_tag="new_3028103_3029246_c" /HighExp="Diami, dia15, dia5, H2O2, G135, G180, G150, C30, Paraq, LBGstat" /AntisenseName="braB" /AntisenseCor="0.41502288403214899" /AntisenseRegPval="-11.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1123" promotor_-35 2524961..2524968 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2524979..2525068 /Source="Nicolas_S_feature" /locus_tag="new_3028207_3028296" /HighExp="LPh, HPh, BMM, dia0, Heat, G180, Cold, LBGexp, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1124" upshifts 2524979 /Source="Nicolas_upshifts" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2524981..2525000 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2525069..2526406 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11528000, 15849754, 16850406, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11528000, 15849754, 16850406, 26473603; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid-Na+ symporter" /protein_id="NP_390838.1" /db_xref="EnsemblGenomes-Gn:BSU29600" /db_xref="EnsemblGenomes-Tr:CAB14938" /db_xref="GOA:O34545" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG12573" /db_xref="UniProtKB/Swiss-Prot:O34545" /translation="MKHSLPVKDTIIIGFMLFALFFGAGNMIYPPELGQAAGHNVWKA IGGFLLTGVGLPLLGIIAIALTGKDAKGLADKAHPVFGTIFTVVLYLSIGPLFAIPRT GTVSYEIGAVPFLTGVPERLSLLIFTLIFFGVTYYLALNPSKVVDRVGKILTPIKFTI ILIIVLKAIFTPMGGLGAVTEAYKGTPVFKGFLEGYKTMDALASIVFGVVVVNAVKSK GVTQSKALAAACIKAGVIAALGLTFIYVSLAYLGATSTNAIGPVGEGAKILSASSHYL FGSLGNIVLGAAITVACLTTSIGLVTSCGQYFSKLIPALSYKIVVTIVTLFSLIIANF GLAQIIAFSVPILSAIYPLAIVIIVLSFIDKIFKERREVYIACLIGTGLFSILDGIKA AGFSLGSLDVFLNANLPLYSLGIGWVLPGIVGAVIGYVLTLFIGPSKQLNEIS*" /label="braB CDS" gene 2525069..2526406 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /label="braB gene" promotor_-10 complement(2526004..2526023) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2526018) /Source="Nicolas_upshifts" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2526038..2526045) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2526382 /Source="Nicolas_upshifts" /id="D1518" /incds=0 /nref=69 /ntot=174 /MaxReadThrough="1.86149" /MaxDrop="6.26921" /score="14.5905051" /energy="-15.2" /TU="U2288" /idTUdmin="U2288" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2526501..2528189) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of FtsZ ring formation" /protein_id="NP_390839.1" /db_xref="EnsemblGenomes-Gn:BSU29610" /db_xref="EnsemblGenomes-Tr:CAB14939" /db_xref="GOA:O34894" /db_xref="InterPro:IPR010379" /db_xref="PDB:4UXV" /db_xref="SubtiList:BG13934" /db_xref="UniProtKB/Swiss-Prot:O34894" /translation="MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSI VEEMSKIKHLKMTGQTEEFFEKWREEWDEIVTAHMPKVEELLYDAEENADKYRFKKAN QVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHL YGELYDSLEKDLDEIWSGIKQFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKL LADCKQTVPGQIAKLKDGYGEMKEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDI DEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDKLKEEKEHTKAETEL VKESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDAEHVAYSLLVEEVASIEKQIE EVKKEHAEYRENLQALRKEELQARETLSNLKKTISETARLLKTSNIPGIPSHIQEMLE NAHHHIQETVNQLNELPLNMEEAGAHLKQAEDIVNRASRESEELVEQVILIEKIIQFG NRFRSQNHILSEQLKEAERRFYAFDYDDSYEIAAAAVEKAAPGAVEKIKADISA*" /label="ezrA CDS" gene complement(2526501..2528189) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /label="ezrA gene" downshifts complement(2526502) /Source="Nicolas_upshifts" /id="D1519" /incds=0 /nref=224 /ntot=257 /MaxReadThrough="3.34218" /MaxDrop="5.3305" /score="9.25784495" /energy="-8.6" /TU="U2290" /idTUdmin="U2290" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2528190..2528295) /Source="Nicolas_S_feature" /locus_tag="new_3031418_3031523_c" /HighExp="C90, Lbtran, BMM, LBGtran, MG 150, S1, Lbexp, dia0, LBGexp, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1125" promotor_-35 2528272..2528280 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2528283..2528302) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2528291..2528310 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2528295) /Source="Nicolas_upshifts" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" upshifts 2528295 /Source="Nicolas_upshifts" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2528296..2528385 /Source="Nicolas_S_feature" /locus_tag="new_3031524_3031613" /HighExp="HiOs, C90, dia5, T-5.40H, S1, T-3.40H, GM-0.1, GM 15, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1126" S_feature complement(2528297..2528856) /Source="Nicolas_S_feature" /locus_tag="new_3031525_3032084_c" /HighExp="Etha, Salt, Cold, G135, Lbstat, G180, G150, H2O2, Heat, Paraq" /AntisenseName="hisJ" /AntisenseCor="0.37018688255337001" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1127" promotor_-35 complement(2528318..2528320) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2528386..2529192 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /EC_number="3.1.3.15" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10322033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol phosphate phosphatase" /protein_id="NP_390840.1" /db_xref="EnsemblGenomes-Gn:BSU29620" /db_xref="EnsemblGenomes-Tr:CAB14940" /db_xref="GOA:O34411" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010140" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG13931" /db_xref="UniProtKB/Swiss-Prot:O34411" /translation="MQKRDGHIHTPFCPHGSNDTLRQYAEEALKKGFESITFTEHAPL PPSFTDPTPLKDSAMAQASLERYIHEISGLKKEYRGQLSIRTGLEVDYIAEFEDEITL FLDTYGPYLDDSILSVHFLRTDSSYLCLDYDEHTFKELISACGSIEAVYEQYYRSIYS SIVASLGVYKPKRVGHITLVQKFIKLFPYSMSEHIRGLVSLCLNAIEENGMELDFNTS GLRKTYAGGIYIEDWMLNEAKQKKIPLVFGSDAHQAGDVGYAYEAFLERC*" /label="hisK CDS" gene 2528386..2529192 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /label="hisK gene" promotor_-10 complement(2528860..2528879) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2528873) /Source="Nicolas_upshifts" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2528891..2528898) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2529142..2529188) /Source="Nicolas_S_feature" /locus_tag="new_3032370_3032416_c" /HighExp="M9-stat, T5.0H, LoTm, T4.0H, S2, BC, T3.30H, S4, T3.0H, B60" /AntisenseName="hisJ" /AntisenseCor="-0.46006853678527698" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1128" downshifts complement(2529164) /Source="Nicolas_upshifts" /id="D1520" /incds=0 /nref=51 /ntot=97 /MaxReadThrough="1.55523" /MaxDrop="6.84653" /score="-4.34170655" /energy="-10.5" /TU="NA" /idTUdmin="U2296" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2529189..2529812) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11988534, 22730127, 26360512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 22730127, 26360512; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of FtsZ defining the chromosome regioncaptured in the forespore" /protein_id="NP_390841.1" /db_xref="EnsemblGenomes-Gn:BSU29630" /db_xref="EnsemblGenomes-Tr:CAB14941" /db_xref="GOA:O34970" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG13927" /db_xref="UniProtKB/Swiss-Prot:O34970" /translation="MKVSTKDKIIESAVMLFNQKGFSGTSVREIAKSADVNVAHISYY FKGKGGLMEHLVSEFYEGYSKTLETAASNISTQSTQEQLLQLVFDILSYQHNHRQLTR FVYREVTIDSTLIREIMSTYLMKEKYIFQLIIEEGEKQREYLTLPLPHFILQLKSLLM MPYLQPQYISEVLYMQPHEPYFYKMYFEEIKIWIRSVFRTGDVALTN*" /label="refZ CDS" gene complement(2529189..2529812) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /label="refZ gene" S_feature 2529193..2529535 /Source="Nicolas_S_feature" /locus_tag="new_3032421_3032763" /HighExp="C90, HiOs, Sw, dia5, GM-0.1, S1, MG 5, UNK1, MG 60, MG t5" /AntisenseName="yttP" /AntisenseCor="-0.79169109805002003" /AntisenseRegPval="-58.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1129" promotor_-35 2529513..2529520 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2529535..2529554 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2529537..2529680 /Source="Nicolas_S_feature" /locus_tag="new_3032765_3032908" /HighExp="Diami, dia15, dia5, H2O2, C90, Paraq, Salt, Etha, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.81457903975257295" /AntisenseRegPval="-64.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1130" upshifts 2529537 /Source="Nicolas_upshifts" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2529652..2529656 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2529672..2529691 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2529682..2529812 /Source="Nicolas_S_feature" /locus_tag="new_3032910_3033040" /HighExp="Diami, dia15, dia5, H2O2, Paraq, C90, HPh, LBGexp, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.82273476313537297" /AntisenseRegPval="-66.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1131" upshifts 2529682 /Source="Nicolas_upshifts" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2529814..2529938 /Source="Nicolas_S_feature" /locus_tag="new_3033042_3033166" /HighExp="Diami, dia5, dia15, H2O2, C90, BC, HiOs, Paraq, Sw, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.598, 0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1132" upshifts 2529814 /Source="Nicolas_upshifts" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2529828..2529846) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2529830..2529849 /Source="Nicolas_upshift_promotors" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2529846) /Source="Nicolas_upshifts" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2529857..2529865) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2529939..2530430 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /EC_number="1.8.4.14" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17535911, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="free methionine-(R)-sulfoxide reductase" /protein_id="NP_390842.2" /db_xref="EnsemblGenomes-Gn:BSU29640" /db_xref="EnsemblGenomes-Tr:CAB14942" /db_xref="InterPro:IPR000614" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG13923" /db_xref="UniProtKB/Swiss-Prot:O34553" /translation="MFHVEKQSGDKEKDYQLLLKQLEAMTEDETDQIANYANASALLY HSLPEVNWAGFYFAKEEDGQLVLGPFQGLPACVRIPFGRGVCGTAYANGKVERIEDVN AFPGHIACDAASQSEIVLPIRVDGKIVGVLDIDSPVKNRFDEIDEKYLTQFAETLEKA LAQ*" /label="msrC CDS" gene 2529939..2530430 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /label="msrC gene" downshifts 2530409 /Source="Nicolas_upshifts" /id="D1521" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="3.66093" /MaxDrop="6.50628" /score="34.0123402" /energy="-11.9" /TU="U2291,U2293,U2294" /idTUdmin="U2295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2530468..2532207) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /EC_number="2.7.7.65" /function="16.12: Sense" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_390843.1" /db_xref="EnsemblGenomes-Gn:BSU29650" /db_xref="EnsemblGenomes-Tr:CAB14943" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG13918" /db_xref="UniProtKB/Swiss-Prot:O34325" /translation="MVEQTKDQLSAFHYHMLDFLLTKSEKVTFTDSFIWLTSAIQTYF STLCVSLTPSPSDFVTKLADGEARFSASKINASCYLIEDGSGRRFHLACRQDEEIPEG LPDVVASFLNQSMKQERLYNKTIYQKKIYKMTELFHSLLDQTDVLKQLLESLTSTFSL FEFSLFISHDQDQCLGIPAKELYMEGEKSDSFALKVYLSGDILRKNESVAYIPIKGQQ GTYGVLKAEGTGDSFLTDACLDEMSLLANAAGKAFENAQLYEQSKASIANLELINETS RRLNQRLTLTDTMNDLAVRMAESFQAEEVGFFHIDHFENLTLLPGSTAFFKEAKPSDF YNELKEKLYEGEKGVFIGNGQSVFGKAGYGSLMAAPMIQNDRLLGFAVLLKQELYAFT FEMYKLFQALIHHATLAVTNSMLRDRLEHLVKTDQLTELYSRAYLDEKIQYSMKIHQK GVFILVDIDNFKNVNDTYGHQTGDEILIQVASVIKSNIRKHDVGARWGGEELAIYLPN VPVAVGKRITERLVYAVRKNTKPEVTISCGISCWTTETKKSLKELVHEADEALYSAKR SGKNRLMIHDSIK*" /label="dgcP CDS" gene complement(2530468..2532207) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /label="dgcP gene" downshifts complement(2530486) /Source="Nicolas_upshifts" /id="D1522" /incds=0 /nref=23 /ntot=178 /MaxReadThrough="3.68958" /MaxDrop="4.52201" /score="-0.637788006" /energy="-11.9" /TU="U2298" /idTUdmin="U2298" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" promotor_-35 2531681..2531688 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-35" promotor_-10 2531702..2531720 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-10" upshifts 2531705 /Source="Nicolas_upshifts" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="upshifts" S_feature 2531707..2532302 /Source="Nicolas_S_feature" /locus_tag="new_3034935_3035530" /HighExp="Cold, LBGstat, C30, Lbstat, GM 25, GM 10, GM 120, GM-0.1, GM 5, GM-0.2" /AntisenseName="ytrP" /AntisenseCor="-0.113221814489707" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1133" misc_feature complement(2532237..2532256) /Source="Nicolas_upshift_promotors" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2532245) /Source="Nicolas_upshifts" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2532247..2533080) /Source="Nicolas_S_feature" /locus_tag="new_3035475_3036308_c" /HighExp="Etha, S7, Gly, S8, M9-stat, Sw, G135, S6, BC, C30" /AntisenseName="rpsD" /AntisenseCor="-0.48019282175486899" /AntisenseRegPval="-16.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1134" promotor_-35 2532283..2532290 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2532304..2532501 /Source="Nicolas_S_feature" /locus_tag="new_3035532_3035729" /HighExp="UNK1, Cold, HPh, C30, aero, LPhT, MG 25, Oxctl, Heat, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.139124" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1135" promotor_-10 2532304..2532323 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2532304 /Source="Nicolas_upshifts" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2532361..2532493 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /product="ribosomal protein S4 leader mRNA sequence" /experiment="publication(s) with functional evidences, PMID:23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23611891" /label="ldsD RNA" gene 2532361..2532493 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /label="ldsD gene" CDS 2532502..2533104 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1400226, 1699930, 1906866, 12682299, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400226, 1699930, 1906866, 12682299, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S4 (BS4)" /protein_id="NP_390844.1" /db_xref="EnsemblGenomes-Gn:BSU29660" /db_xref="EnsemblGenomes-Tr:CAB14944" /db_xref="GOA:P21466" /db_xref="InterPro:IPR001912" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR005709" /db_xref="InterPro:IPR018079" /db_xref="InterPro:IPR022801" /db_xref="InterPro:IPR036986" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10372" /db_xref="UniProtKB/Swiss-Prot:P21466" /translation="MARYTGPSWKLSRRLGISLSGTGKELEKRPYAPGPHGPGQRKKL SEYGLQLQEKQKLRHMYGVNERQFRTLFDKAGKLAGKHGENFMILLDSRLDNVVYKLG LARTRRQARQLVNHGHILVDGSRVDIPSYLVKPGQTIGVREKSRNLSIIKESVEVNNF VPEYLTFDAEKLEGTFTRLPERSELAPEINEALIVEFYSR*" /label="rpsD CDS" gene 2532502..2533104 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /label="rpsD gene" downshifts 2533027 /Source="Nicolas_upshifts" /id="D1523" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="8.1141" /MaxDrop="2.9392" /score="31.6842" /energy="-13.6" /TU="U2297,U2299" /idTUdmin="U2297" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(2533082..2533301) /Source="Nicolas_S_feature" /locus_tag="new_3036310_3036529_c" /HighExp="S5, Etha, S8, S6, S7, S4, BT, S3, M9-stat, B36" /AntisenseName="rpsD" /AntisenseCor="-0.59018291599064199" /AntisenseRegPval="-25.9" /CDS_PredictionProba="0.99997899999999995" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1136" downshifts 2533090 /Source="Nicolas_upshifts" /id="D1524" /incds=0 /nref=135 /ntot=252 /MaxReadThrough="5.6866" /MaxDrop="6.10502" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=19 /isTUend="TRUE" /label="downshifts" downshifts complement(2533125) /Source="Nicolas_upshifts" /id="D1525" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="4.84346" /MaxDrop="3.28594" /score="-4.07107651" /energy="-10.8" /TU="U2300" /idTUdmin="U2301" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2533137 /Source="Nicolas_upshifts" /id="D1526" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="5.7799" /MaxDrop="4.26349" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2533182..2533355 /Source="Nicolas_S_feature" /locus_tag="new_3036410_3036583" /HighExp="LBGtran, LoTm, C30, Cold, LBGexp, B60, dia15, B36, H2O2, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig=1 /label="S1137" promotor_-10 complement(2533297..2533315) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2533309) /Source="Nicolas_upshifts" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="upshifts" downshifts 2533313 /Source="Nicolas_upshifts" /id="D1527" /incds=0 /nref=7 /ntot=151 /MaxReadThrough="1.39547" /MaxDrop="6.12149" /score="26.4940291" /energy="-16.4" /TU="NA" /idTUdmin="U2299" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2533330..2533336) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2533375..2534643) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /EC_number="6.1.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12547201, 15879350, 1735721, 9098057" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12547201, 15879350, 1735721, 9098057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_390845.1" /db_xref="EnsemblGenomes-Gn:BSU29670" /db_xref="EnsemblGenomes-Tr:CAB14945" /db_xref="GOA:P22326" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024107" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10371" /db_xref="UniProtKB/Swiss-Prot:P22326" /translation="MTNLLEDLSFRGLIQQMTDEEGLNKQLNEEKIRLYSGFDPTADS LHIGHLLPILTLRRFQLAGHHPIALVGGATGLIGDPSGKKAERTLNTADIVSEWSQKI KNQLSRFLDFEAAENPAVIANNFDWIGKMNVIDFLRDVGKNFGINYMLAKDTVSSRIE SGISYTEFSYMILQSYDFLNLYRDKNCKLQIGGSDQWGNITAGLELIRKSEEEGAKAF GLTIPLVTKADGTKFGKTEGGAIWLDKEKTSPYEFYQFWINTDDRDVVKYLKYFTFLS KEEIEAYAEKTETAPEKREAQKRLAEEVTSLVHGREALEQAINISQALFSGNIKELSA QDVKVGFKDVPSMEVDSTQELSLVDVLVQSKLSPSKRQAREDIQNGAVYINGERQTEI NYTLSGEDRIENQFTVLRRGKKKYFLVTYK*" /label="tyrS CDS" gene complement(2533375..2534643) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /label="tyrS gene" downshifts complement(2533401) /Source="Nicolas_upshifts" /id="D1528" /incds=0 /nref=110 /ntot=357 /MaxReadThrough="2.2673" /MaxDrop="6.847" /score="22.5238672" /energy="-16.4" /TU="NA" /idTUdmin="U2301" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" misc_RNA complement(2534667..2534940) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /product="T-Box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 10943892, 1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 10943892, 1317842, 9098041, 12165569, 12547201; Product type n : RNA" /function="16.3: Control" /label="tboY RNA" gene complement(2534667..2534940) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /label="tboY gene" S_feature complement(2534688..2534831) /Source="Nicolas_S_feature" /locus_tag="new_3037916_3038059_c" /HighExp="B60, Sw, B36, BC, M9-stat, T1.30H, S4, T4.0H, T2.30H, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40126600000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1138" downshifts complement(2534731) /Source="Nicolas_upshifts" /id="D1529" /incds=0 /nref=58 /ntot=127 /MaxReadThrough="6.75235" /MaxDrop="6.49727" /score="45.7279775" /energy="-17.7" /TU="U2301,U2303" /idTUdmin="U2301" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2534938..2534957) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2534950) /Source="Nicolas_upshifts" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2534970..2534977) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2534985..2536703) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /EC_number="6.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7934817, 10986270, 11255012, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10986270, 11255012, 16855235, 18487328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA synthetase" /protein_id="NP_390846.1" /db_xref="EnsemblGenomes-Gn:BSU29680" /db_xref="EnsemblGenomes-Tr:CAB14946" /db_xref="GOA:P39062" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG10370" /db_xref="UniProtKB/Swiss-Prot:P39062" /translation="MNLKALPAIEGDHNLKNYEETYRHFDWAEAEKHFSWHETGKLNA AYEAIDRHAESFRKNKVALYYKDAKRDEKYTFKEMKEESNRAGNVLRRYGNVEKGDRV FIFMPRSPELYFIMLGAIKIGAIAGPLFEAFMEGAVKDRLENSEAKVVVTTPELLERI PVDKLPHLQHVFVVGGEAESGTNIINYDEAAKQESTRLDIEWMDKKDGFLLHYTSGST GTPKGVLHVHEAMIQQYQTGKWVLDLKEEDIYWCTADPGWVTGTVYGIFAPWLNGATN VIVGGRFSPESWYGTIEQLGVNVWYSAPTAFRMLMGAGDEMAAKYDLTSLRHVLSVGE PLNPEVIRWGHKVFNKRIHDTWWMTETGSQLICNYPCMDIKPGSMGKPIPGVEAAIVD NQGNELPPYRMGNLAIKKGWPSMMHTIWNNPEKYESYFMPGGWYVSGDSAYMDEEGYF WFQGRVDDVIMTSGERVGPFEVESKLVEHPAIAEAGVIGKPDPVRGEIIKAFIALREG FEPSDKLKEEIRLFVKQGLAAHAAPREIEFKDKLPKTRSGKIMRRVLKAWELNLPAGD LSTMED*" /label="acsA CDS" gene complement(2534985..2536703) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /label="acsA gene" promotor_-35 2536717..2536724 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2536731..2536750) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2536739..2536758 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2536745 /Source="Nicolas_upshifts" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2536754) /Source="Nicolas_upshifts" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2536764..2536770) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2536787..2536794 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2536808..2536827 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2536811 /Source="Nicolas_upshifts" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2536864..2537496 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein acetyltransferase (acetylates AcsA)" /protein_id="NP_390847.1" /db_xref="EnsemblGenomes-Gn:BSU29690" /db_xref="EnsemblGenomes-Tr:CAB14947" /db_xref="GOA:P39065" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR024699" /db_xref="SubtiList:BG10369" /db_xref="UniProtKB/Swiss-Prot:P39065" /translation="MEHHKTYHSANIKTATGSLLIEGPVSPEDLAGYEFHKDLTAFRP PREQHEALVDIAGLPEGRIIIARDGRTIVGYVTYLYPDPLERWSEGNMEDLIELGAIE VAPDYRGCAVGKTLLTVSMMDEQMENYIVMTTEYYWHWDLKGMKKDVWEYRKIMEKMM NAGGLVWFATDEPEISSHPANCLMARIGKNVSQESIEQFDRLRFYHRYMY*" /label="acuA CDS" gene 2536864..2537496 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /label="acuA gene" promotor_-35 2537069..2537077 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2537091..2537110 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2537097 /Source="Nicolas_upshifts" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2537523..2538167 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type f : factor" /codon_start=1 /transl_table=11 /product="component of the acetyl-coenzyme A synthetase regulation pathway" /protein_id="NP_390848.1" /db_xref="EnsemblGenomes-Gn:BSU29700" /db_xref="EnsemblGenomes-Tr:CAB14948" /db_xref="GOA:P39066" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG10368" /db_xref="UniProtKB/Swiss-Prot:P39066" /translation="MIVEQIMKRDVITLTKTDTLETAICKLKEFHIRHLPVVDEERHV IGMITDRDMKQASPSIFEENKRSLFLTRSVDSIMKKDVVCAHPLDFVEEISAVFYEHG IGCLPVVHHQKLIGILTKTDLLRTFVKLTGADQPGSQIEIKVNDITKSLAEISSLCQD LQVKILSVLVYPHDDPGVKVLVFRVKTMNPLPFLQALQRNGHHVVWPSEQRDLL*" /label="acuB CDS" gene 2537523..2538167 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /label="acuB gene" CDS 2538164..2539327 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein deacetylase (regulates AcsA activity)" /protein_id="NP_390849.1" /db_xref="EnsemblGenomes-Gn:BSU29710" /db_xref="EnsemblGenomes-Tr:CAB14949" /db_xref="GOA:P39067" /db_xref="InterPro:IPR000286" /db_xref="InterPro:IPR003085" /db_xref="InterPro:IPR023696" /db_xref="InterPro:IPR023801" /db_xref="InterPro:IPR037138" /db_xref="SubtiList:BG10367" /db_xref="UniProtKB/Swiss-Prot:P39067" /translation="MRDSVFIYSPSYQTYMFHQEHPFNQQRVLLTYDLLKTINAFDDG DIVTPRLASEEELSLVHTDDYIQAVKLAGAGKLPAEEGESYGLGTEDTPVFAGMHEAA SLLVGGTLTAADWVMSGQALHAANLGGGLHHGFRGRASGFCIYNDSAVAIQYIQKKYS ARVLYIDTDAHHGDGVQFTFYDNPDVCTLSIHETGRYLFPGTGQIQEKGSGKGYGYSF NIPLDAFTEDDSFLEAYRTAASEVAAYFEPDVIISQNGADAHYYDPLTHLSATINIYE EIPRLAHTLAHQYCGGKWIAVGGGGYDIWRVVPRAWARIWLEMKGIDPGHEIPPEWIV KWQKQCPVALPSSWSDPADLYPPIPRKPEITEKNAQTVSKALYAIRSEQQRTK*" /label="acuC CDS" gene 2538164..2539327 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /label="acuC gene" downshifts 2539318 /Source="Nicolas_upshifts" /id="D1530" /incds=0 /nref=98 /ntot=231 /MaxReadThrough="0.530530000000001" /MaxDrop="6.5095" /score="10.9528437" /energy="-9.1" /TU="NA" /idTUdmin="U2304" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2539338..2540066) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator peptidoglycan binding subunit of flagellar rotation" /protein_id="NP_390850.1" /db_xref="EnsemblGenomes-Gn:BSU29720" /db_xref="EnsemblGenomes-Tr:CAB14950" /db_xref="GOA:P39064" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10366" /db_xref="UniProtKB/Swiss-Prot:P39064" /translation="MKLRRERFERRNGSGKNSQSSSSWMVTFTDLITLILVFFILLFS MSQIDLQKFKAAVDSIQKEGNGLQPDQTSIEKKNTSPSDTKKQEDQQDQLLKKVNTYI KDNHLKAQMTAKRDERGVVLVLQEAVLFDTGEAKVLKNAETLLHQIAVLLQTIPNDIQ VEGHTDSRNISTYRYPSNWELSAARASGVIQYFTSKEKLPSKRFIAVGYADTKPVKDN KTNEHMKENRRVEIVIKKSKTTSS*" /label="motS CDS" gene complement(2539338..2540066) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /label="motS gene" downshifts complement(2539374) /Source="Nicolas_upshifts" /id="D1531" /incds=0 /nref=37 /ntot=149 /MaxReadThrough="1.3853" /MaxDrop="3.98206" /score="4.77211813" /energy="-6.9" /TU="NA" /idTUdmin="U2307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2540056..2540874) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator subunit offlagellar rotation" /protein_id="NP_390851.1" /db_xref="EnsemblGenomes-Gn:BSU29730" /db_xref="EnsemblGenomes-Tr:CAB14951" /db_xref="GOA:P39063" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10365" /db_xref="UniProtKB/Swiss-Prot:P39063" /translation="MKRFDYLTPVGFVLGTIIIVIGIISGSGVSGFRSFLDLTSFFIV TGGLCAAVFISFPPSELKKAPSVLKQAFIRQEDNVKDLVKTFVSLSDHARKHGLLSLD DQAREIKDPFLKKGLLLAIDGWDEETIRLVMDSEIAAMEERHRKGRRVFEKAGEFAPA WGMIGTLVGLVLMLKNLNDPHMLGPNMAIALLTTLYGSLLANMVFNPIAAKLEEKTES EIFIKQVMVEGIIGVQSGKNPRNLESQLVVFSSREEWQKQPKQVKTKKGSVHEA*" /label="motP CDS" gene complement(2540056..2540874) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /label="motP gene" CDS complement(2540937..2541941) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catabolite repression (Lacl family)" /protein_id="NP_390852.1" /db_xref="EnsemblGenomes-Gn:BSU29740" /db_xref="EnsemblGenomes-Tr:CAB14952" /db_xref="GOA:P25144" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR006377" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="PDB:1ZVV" /db_xref="PDB:2FEP" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10376" /db_xref="UniProtKB/Swiss-Prot:P25144" /translation="MSNITIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIER LGYRPNAVARGLASKKTTTVGVIIPDISSIFYSELARGIEDIATMYKYNIILSNSDQN MEKELHLLNTMLGKQVDGIVFMGGNITDEHVAEFKRSPVPIVLAASVEEQEETPSVAI DYEQAIYDAVKLLVDKGHTDIAFVSGPMAEPINRSKKLQGYKRALEEANLPFNEQFVA EGDYTYDSGLEALQHLMSLDKKPTAILSATDEMALGIIHAAQDQGLSIPEDLDIIGFD NTRLSLMVRPQLSTVVQPTYDIGAVAMRLLTKLMNKEPVEEHIVELPHRIELRKSTKS *" /label="ccpA CDS" gene complement(2540937..2541941) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /label="ccpA gene" downshifts complement(2540954) /Source="Nicolas_upshifts" /id="D1532" /incds=0 /nref=62 /ntot=239 /MaxReadThrough="4.60553" /MaxDrop="4.6531" /score="5.3377823" /energy="-13.2" /TU="U2307,U2308,U2309" /idTUdmin="U2306" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(2541976..2541995) /Source="Nicolas_upshift_promotors" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2541991) /Source="Nicolas_upshifts" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2541993..2542101) /Source="Nicolas_S_feature" /locus_tag="new_3045221_3045329_c" /HighExp="Oxctl, H2O2, Paraq, MG-0.1, MG-0.2, G150, GM 15, Diami, LBGexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigB" /TUshortPSig="0.988, 1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1139" promotor_-10 complement(2542101..2542120) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2542101) /Source="Nicolas_upshifts" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2542103..2542168) /Source="Nicolas_S_feature" /locus_tag="new_3045331_3045396_c" /HighExp="BMM, GM 120, Diami, GM 90, M/G, GM 25, M9-exp, HiTm, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1140" promotor_-35 complement(2542134..2542140) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2542214) /Source="Nicolas_upshifts" /id="D1533" /incds=0 /nref=66 /ntot=188 /MaxReadThrough="6.10221" /MaxDrop="6.29667" /score="46.0872381" /energy="-11.3" /TU="U2308,U2309,U2310" /idTUdmin="U2311" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2542217..2543293) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /EC_number="2.5.1.54" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4200844, 7496534, 11444986, 16339761, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4200844, 7496534, 11444986, 16339761, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional chorismate mutase type II-isozyme 3(regulatory domain); 3-deoxy-D-arabino-heptulosonate7-phosphate synthase" /protein_id="NP_390853.1" /db_xref="EnsemblGenomes-Gn:BSU29750" /db_xref="EnsemblGenomes-Tr:CAB14953" /db_xref="GOA:P39912" /db_xref="InterPro:IPR002701" /db_xref="InterPro:IPR006218" /db_xref="InterPro:IPR006268" /db_xref="InterPro:IPR010954" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036979" /db_xref="PDB:5GMU" /db_xref="PDB:5GO2" /db_xref="SubtiList:BG10375" /db_xref="UniProtKB/Swiss-Prot:P39912" /translation="MSNTELELLRQKADELNLQILKLINERGNVVKEIGKAKEAQGVN RFDPVRERTMLNNIIENNDGPFENSTIQHIFKEIFKAGLELQEEDHSKALLVSRKKKP EDTIVDIKGEKIGDGQQRFIVGPCAVESYEQVAEVAAAAKKQGIKILRGGAFKPRTSP YDFQGLGVEGLQILKRVADEFDLAVISEIVTPAHIEEALDYIDVIQIGARNMQNFELL KAAGAVKKPVLLKRGLAATISEFINAAEYIMSQGNDQIILCERGIRTYETATRNTLDI SAVPILKQETHLPVFVDVTHSTGRRDLLLPTAKAALAIGADGVMAEVHPDPSVALSDS AQQMAIPEFEKWLNELKPMVKVNA*" /label="aroX CDS" gene complement(2542217..2543293) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /label="aroX gene" promotor_-10 complement(2543334..2543353) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-10" upshifts complement(2543354) /Source="Nicolas_upshifts" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="upshifts" S_feature complement(2543356..2543456) /Source="Nicolas_S_feature" /locus_tag="new_3046584_3046684_c" /HighExp="Lbtran, BMM, dia5, GM 25, GM 90, M9-exp, MG 150, Diami, MG-0.2, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigH" /TUshortPSig="0.974, 1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1141" promotor_-35 complement(2543368..2543375) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-35" downshifts 2543390 /Source="Nicolas_upshifts" /id="D1534" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.07872" /MaxDrop="3.23284" /score="1.10447256" /energy="-7.6" /TU="NA" /idTUdmin="U2304" /TUdmin=4071 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2543444..2543463) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2543456) /Source="Nicolas_upshifts" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2543477..2543483) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2543529..2543855) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22938038, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22938038, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin involved in debacillithiolation" /protein_id="NP_390854.1" /db_xref="EnsemblGenomes-Gn:BSU29760" /db_xref="EnsemblGenomes-Tr:CAB14954" /db_xref="InterPro:IPR022551" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10373" /db_xref="UniProtKB/Swiss-Prot:P39914" /translation="MAKQLIQSEEEFKRIAEQEGVFVFLKHSTTCPISQAAFHEFDAF ANQHEDVPAYYLQVQEARPLSNFIAETYGVKHESPQIFIIQNGEVKWHTSHSQITEAA IEQHLS*" /label="brxJ CDS" gene complement(2543529..2543855) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /label="brxJ gene" downshifts complement(2543538) /Source="Nicolas_upshifts" /id="D1535" /incds=0 /nref=144 /ntot=286 /MaxReadThrough="7.09736" /MaxDrop="5.96753" /score="13.8032115" /energy="-7.6" /TU="U2310,U2311" /idTUdmin="U2313" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2543879..2544334) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8733232, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390855.2" /db_xref="EnsemblGenomes-Gn:BSU29770" /db_xref="EnsemblGenomes-Tr:CAB14955" /db_xref="InterPro:IPR024623" /db_xref="SubtiList:BG10975" /db_xref="UniProtKB/Swiss-Prot:P40780" /translation="MSKDGINSKDFLIGTLIGGIIGATTALFLAPKSGKELRDDLGSQ AVALRDKTDKMTADAKEKGTQYVSIAKDKTSNITQLVADQSGQIMNKVKDLRDRSKSD KTDSSTAMQDMREEAMQAADETKDQVLQTKEDVKDELKDAQKQAEQLNR*" /label="ytxH CDS" gene complement(2543879..2544334) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /label="ytxH gene" CDS complement(2544365..2544787) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22720735, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein" /protein_id="NP_390856.2" /db_xref="EnsemblGenomes-Gn:BSU29780" /db_xref="EnsemblGenomes-Tr:CAB14956" /db_xref="GOA:P40779" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG10974" /db_xref="UniProtKB/Swiss-Prot:P40779" /translation="MIIILYLSVALIAVAFLVLVIYLSKTLKSLQLTLKNVASTLEGL EGQMKGITTETAELLHKTNRLAEDIQEKSEKLNTVVHAVQGVGASVQQFNTSMKQAAG SVSASVRENQDKINQVVTWSQAAMEIWEKWKQKKKSAL*" /label="ytxG CDS" gene complement(2544365..2544787) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /label="ytxG gene" promotor_-10 complement(2544808..2544826) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2544821) /Source="Nicolas_upshifts" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2544840..2544846) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2544860..2544878) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-10" upshifts complement(2544869) /Source="Nicolas_upshifts" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="upshifts" promotor_-35 complement(2544889..2544897) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-35" CDS complement(2544949..2546247) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /EC_number="6.3.2.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10565540, 12682299, 12781748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetyl muramate-alanine ligase" /protein_id="NP_390857.1" /db_xref="EnsemblGenomes-Gn:BSU29790" /db_xref="EnsemblGenomes-Tr:CAB14957" /db_xref="GOA:P40778" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005758" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10973" /db_xref="UniProtKB/Swiss-Prot:P40778" /translation="MTVYHFVGIKGTGMSPLAQILHDNGYTVQGSDIEKFIFTQTALE KRNITILPFSAENIKPGMTVIAGNAFPDTHPEIEKAMSEGIPVIRYHKFLGDYMKKFT SVAVTGAHGKTSTTGLLAHVIQNAKPTSFLIGDGTGQGNENSEYFVFEACEYRRHFLS YQPDYAIMTNIDFDHPDYFSSIDDVFDAFQEMALQVNKGIIACGDDEHLPKIHANVPV VYYGTGEENDFQARNIVKSTEGTTFDVFVRNTFYDTFYIPAYGHHNVLNSLAVIALCH YEEIDSSIIKHALKSFGGVKRRFNEKQLGDQVLIDDYAHHPTEIKVTIEAARQKYPDR EIVAVFQPHTFTRTQQFLDEFAESLSGADCVYLCDIFGSARENAGKLTIGDLQGKIHN AKLIEEDDTSVLKAHDKAVLIFMGAGDIQKYMRAYENVMA*" /label="murC CDS" gene complement(2544949..2546247) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /label="murC gene" downshifts complement(2544958) /Source="Nicolas_upshifts" /id="D1536" /incds=0 /nref=29 /ntot=180 /MaxReadThrough="5.23049" /MaxDrop="5.42617" /score="15.3729968" /energy="-7.5" /TU="U2313,U2314" /idTUdmin="U2312" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2546272..2546291) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2546273) /Source="Nicolas_upshifts" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2546275..2546471) /Source="Nicolas_S_feature" /locus_tag="new_3049503_3049699_c" /HighExp="Cold, G150, G135, dia15, G180, H2O2, C30, Oxctl, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.938" /label="S1142" promotor_-35 complement(2546304..2546313) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2546454..2546473) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2546471) /Source="Nicolas_upshifts" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2546485..2546491) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2546497..2549355) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /function="8.1: DNA replication, recombination, and repair" /experiment="publication(s) with functional evidences, PMID:3129532, 11134515, 11208805, 19788545, 28110333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3129532, 11134515, 11208805, 19788545, 28110333; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="DNA translocase" /protein_id="NP_390859.2" /db_xref="EnsemblGenomes-Gn:BSU29805" /db_xref="EnsemblGenomes-Tr:CAB14959" /db_xref="GOA:C0SP86" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13906" /db_xref="UniProtKB/Swiss-Prot:C0SP86" /translation="MSWLHKFFDLFLGESEEDAERETKPAQIPQQQEVHHPEGQLKRL EDPKIYYEYPKGKFRFPVVPDGYKNHDLRRRRTPSDEPKSAPRPSAAPYRERPRNEEE QHTYQAAEPAKKPFKPTNIPSPVYGFNQKPSVKKDVPKKPSETLNEPDKSVKEKVTLL SEEIERERGYPASDTQAHSKIESPFFPDTQFEKQPSGVLNRKDTEHDEALAKRPAEPS GNKVPFESGVQQPEKEEPFFPAEQAEEQTPPEMLTDTAAEGLSDSEVGREEPATAEEE QREQQPEKFEEPVFSAELDEEQTAPESQTEAVSEDEKAKEPSDSPVYNHHENAAEGAE SPFVQEEQMDIRQEEPLFTDHEYSSEALAQAETVAKESEEPSESIINNHYDTLGEAQE TKIDVQPDSHTELEKTEHMEQGSKSSTATLENRQEIRADKPREASEEPKKRPGVQEKR TEQSASSQKGPSVPFNVMMLKRDTHKQQKAEERRGSYVFPNVALLDVPPAQVQDDTAW IEEQRQLLDLTLKNFNVRANVVHVTQGPSVTRFEVHPEPGVKVNKITNLSDDIKLSLS AKDIRIEAPIPGKNTIGIEVPNRTSKVVDLRQMIRSSAFRTSKSPLTAALGLDISGNP VVIDLKKMPHGLIAGATGSGKSVCINTILVSLLYKADPSEVKVLLIDPKMVELAPYNK IPHLVSPVITDAKAATAALKWVVEEMERRYELFAHSGVRDIDRFNQLTAEHQMGEKLP YLVVIIDELADLMMVAPNDVEESIARIAQKARACGIHLLVATQRPSVDVITGLIKANI PTRIAFSVSSQVDSRTIIDIAGAEKLLGKGDMLFLENGSGKPVRLQGNFVSDREIDRV VSHVRSQMPPTYLFEQEELVRQGSALKEEDELFYEACEFVVEQNSASTSSLQRRFRIG YNRAARLIDMMEAEGMISEAKGSKPREVLITASDLINE*" /label="sftA CDS" gene complement(2546497..2549355) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /label="sftA gene" promotor_-10 complement(2549389..2549408) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-10" upshifts complement(2549399) /Source="Nicolas_upshifts" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="upshifts" promotor_-35 complement(2549424..2549428) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-35" downshifts complement(2549498) /Source="Nicolas_upshifts" /id="D1537" /incds=0 /nref=186 /ntot=249 /MaxReadThrough="4.47299" /MaxDrop="6.35097" /score="9.62039509" /energy="-14.5" /TU="U2315" /idTUdmin="U2315" /TUdmin="-1553" /isTUend="FALSE" /label="downshifts" CDS complement(2549515..2550120) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21949854, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA binding enzyme" /protein_id="NP_390860.1" /db_xref="EnsemblGenomes-Gn:BSU29820" /db_xref="EnsemblGenomes-Tr:CAB14960" /db_xref="GOA:O34943" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027855" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR037154" /db_xref="SubtiList:BG13905" /db_xref="UniProtKB/Swiss-Prot:O34943" /translation="MNAFYNKEGVGDTLLISLQDVTREQLGYEKHGDVVKIFNNETKE TTGFNIFNASSYLTIDENGPVALSETFVQDVNEILNRNGVEETLVVDLSPKFVVGYVE SKEKHPNADKLSVCKVNVGEETLQIVCGAPNVDQGQKVVVAKVGAVMPSGLVIKDAEL RGVPSSGMICSAKELDLPDAPAEKGILVLEGDYEAGDAFQF*" /label="ytpR CDS" gene complement(2549515..2550120) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /label="ytpR gene" CDS complement(2550136..2550945) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12719520, 21949854" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (iron homeostasis)" /protein_id="NP_390861.1" /db_xref="EnsemblGenomes-Gn:BSU29830" /db_xref="EnsemblGenomes-Tr:CAB14961" /db_xref="InterPro:IPR010838" /db_xref="SubtiList:BG13904" /db_xref="UniProtKB/Swiss-Prot:O34496" /translation="MKMTSRKLSDILKQRLQHENRSFLFDREKDTLRVEDQTTKKGIT LDLPPIIAKWELKKDEAIDEIVYYVSEAMTAMEGKAQEMTGKETRIYPVIRSTSFPDK SSEDIPLIYDDHTAETRIYYALDLGKTYRLIDQRMLEKENWTKERIRETAAFNLRSLP TVVKEDTVAGNYFYFFRANDGYDASRILNEAILNEYKQHAEGELAISVPHQDVLILAD IRNESGYDILGQMSMSFFAGGTVPITALSFLYNEGKLEPVFILAKSRPKKD*" /label="ytpQ CDS" gene complement(2550136..2550945) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /label="ytpQ gene" CDS complement(2550960..2551283) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12719520, 15937154, 21949854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_390862.1" /db_xref="EnsemblGenomes-Gn:BSU29840" /db_xref="EnsemblGenomes-Tr:CAB14962" /db_xref="GOA:O34357" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13903" /db_xref="UniProtKB/Swiss-Prot:O34357" /translation="MKKIESTQELEKAVKDDWSVFMFSADWCPDCRFVEPFLPELEAN FPEFTYYYVDRDKFIDTCAEWEIYGIPSFVVFNEGKEVNRFVSKDRKTKEEIEQFLTD SLAKA*" /label="ytpP CDS" gene complement(2550960..2551283) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /label="ytpP gene" S_feature complement(2551284..2551422) /Source="Nicolas_S_feature" /locus_tag="new_3054512_3054650_c" /HighExp="G180, G150, Paraq, Oxctl, H2O2, Diami, C90, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.32150299999999998" /TUshortSig="SigA" /TUshortPSig="0.938" /TUlongSig="NA" /TUlongPSig="NA" /label="S1143" CDS complement(2551322..2551438) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513998.1" /translation="MQIKYDNDNGKANLTYSFVAYKWFCLKQFGMIQMDEYR*" /label="hypothetical protein CDS" gene complement(2551322..2551438) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /label="gene" promotor_-10 complement(2551409..2551428) /Source="Nicolas_upshift_promotors" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="promotor_-10" upshifts complement(2551422) /Source="Nicolas_upshifts" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="upshifts" promotor_-35 2551430..2551437 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2551452..2551471 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2551457 /Source="Nicolas_upshifts" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="upshifts" CDS 2551518..2551964 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with sugar binding fold" /protein_id="NP_390863.1" /db_xref="EnsemblGenomes-Gn:BSU29850" /db_xref="EnsemblGenomes-Tr:CAB14963" /db_xref="InterPro:IPR019884" /db_xref="SubtiList:BG13899" /db_xref="UniProtKB/Swiss-Prot:O34305" /translation="MEFIVYLAGEIHSNWREEIKEKTKSLKLPITFVGPMENHDRSDN IGEEIMGVQPNAVLKDDKASDINNFRTAVLMNKADFVIALFGEKYKQWNTAMDASYAI AKGKPLIIIRPESLHHPLKELSNKANITVETVNQAIKALSYLFETE*" /label="ytoQ CDS" gene 2551518..2551964 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /label="ytoQ gene" S_feature 2551965..2552693 /Source="Nicolas_S_feature" /locus_tag="new_3055193_3055921" /HighExp="H2O2, dia15, C30, C90, Diami, S1, M0t45, Salt, Paraq, Lbexp" /AntisenseName="ytoP" /AntisenseCor="0.35418735783791" /AntisenseRegPval="-8.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.981" /TUlongSig="NA" /TUlongPSig="NA" /label="S1144" CDS complement(2552019..2553092) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8535515; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative modified amino acid aminopeptidase" /protein_id="NP_390864.1" /db_xref="EnsemblGenomes-Gn:BSU29860" /db_xref="EnsemblGenomes-Tr:CAB14964" /db_xref="GOA:O34924" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13898" /db_xref="UniProtKB/Swiss-Prot:O34924" /translation="MNQETKALFQTLTQLPGAPGNEHQVRAFMKQELAKYADDIVQDR LGSVFGVRRGAEDAPRIMVAGHMDEVGFMVTSITDNGLLRFQTLGGWWSQVLLAQRVE IQTDNGPVPGVISSIPPHLLTDAQRNRPMDIKNMMIDIGADDKEDAIKIGIRPGQQIV PVCPFTTMANEKKILSKAWDNRYGCGLSIELLKELHGKELPNTLYAGATVQEEVGLRG AQTASHMIKPDLFFALDASPANDMSGDKNEFGQLGKGFLLRILDRTTVMHRGMREFVL DMAETHDIPYQYFVSGGGTDAGKVHISNSGVPSAVIGICSRYIHTNATIIHIDDYAAA KEMLIKLVTACDKQTVDAIKENM*" /label="ytoP CDS" gene complement(2552019..2553092) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /label="ytoP gene" downshifts complement(2552038) /Source="Nicolas_upshifts" /id="D1538" /incds=0 /nref=140 /ntot=248 /MaxReadThrough="1.89952" /MaxDrop="4.55096" /score="14.9571314" /energy="-14.4" /TU="NA" /idTUdmin="U2317" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2553114..2553133) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2553118) /Source="Nicolas_upshifts" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2553147..2553154) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2553189..2553192 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2553207..2553226 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2553212 /Source="Nicolas_upshifts" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="upshifts" CDS 2553251..2553568 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390865.1" /db_xref="EnsemblGenomes-Gn:BSU29870" /db_xref="EnsemblGenomes-Tr:CAB14965" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13936" /db_xref="UniProtKB/Swiss-Prot:O32065" /translation="MKLRHLLLGAGLGICTAVVVRQYVMKPYISSEKALRIVKSAFKQ RGPIDGSWIYTQPEPYNINGETVQVYKTGITRSAFGELEQYEVMVDAKTGEIVDVIDT IAS*" /label="ytzB CDS" gene 2553251..2553568 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /label="ytzB gene" downshifts 2553568 /Source="Nicolas_upshifts" /id="D1539" /incds=0 /nref=250 /ntot=259 /MaxReadThrough="1.29231" /MaxDrop="7.83082" /score="44.9062865" /energy="-17" /TU="NA" /idTUdmin="U2318" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2553621..2555321) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 20933603, 22740702, 23136871, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_390866.1" /db_xref="EnsemblGenomes-Gn:BSU29880" /db_xref="EnsemblGenomes-Tr:CAB14966" /db_xref="GOA:O34389" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG12614" /db_xref="UniProtKB/Swiss-Prot:O34389" /translation="MKQFRVTNEGDIQTTLRGLEVLSVPFLNKGVAFTEEERKELGLK GFLPPKVLTIDDQAKRAYEQYSAQPDDLSKNVYLTALHDRNETLFYRLLNDHLGEMLP IVYTPTVGTAIQRYSHEYRKPRGLYLSIDDPDGMKEAFKQYKDQSDTIDLIVATDAEG ILGIGDWGVGGIAISIGKLAVYTAAAGIDPSRVLAVVLDAGTNQESLLNDPLYVGNQH SRVRGERYDQFIDDYVALARETFPNALLHWEDFGAKNARSILKRYKDKVCTFNDDIQG TGAVSLAAVLSCAKASKVPLRDHRVVIFGAGTAGIGIAEQLREALVREGLSEEESYKR FWCIDRNGLLTDDMDQLLDFQKPYARSADEVKDYQRNGDGGGIDLLEVVRQAKPTILI GTSTVSGAFTEEIVKEMASHVKRPAILPMSNPTTLSEAKPEDLIEWTEGRALITTGSP FPPVEYNGVTYHIGQANNALVFPGLGLGTIVTKSKLITDGMFEACARAIAGMVNVGVP GAPMLPKVEDLRTVSATVAVEVAKTAMKEGVATEEPEDIIQAVQDAMWYPVYKPIRAI *" /label="maeC CDS" gene complement(2553621..2555321) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /label="maeC gene" downshifts complement(2553640) /Source="Nicolas_upshifts" /id="D1540" /incds=0 /nref=77 /ntot=255 /MaxReadThrough="2.4872" /MaxDrop="4.99085" /score="17.675308" /energy="-15.3" /TU="NA" /idTUdmin="U2319" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2555353..2555371) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2555360) /Source="Nicolas_upshifts" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2555386..2555392) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2555403..2556173) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22101040, 24268182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative quorum-quenching lactonase" /protein_id="NP_390867.1" /db_xref="EnsemblGenomes-Gn:BSU29890" /db_xref="EnsemblGenomes-Tr:CAB14967" /db_xref="GOA:O34760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13895" /db_xref="UniProtKB/Swiss-Prot:O34760" /translation="MFGVVPKPLWSKKYPVNEKNQIELRTDPILIQKDGLNIIIDAGI GYGKLTDKQKRNYGVTQESNVKPSLAALGLTVADIDVIAMTHLHFDHACGLTEYEGER LVSVFPNAVIYTSAVEWDEMRHPNIRSKNTYWKENWEAVAGQVKTFEDTLTITEGITM HHTGGHSDGHSVLICEDAGETAVHMADLMPTHAHRNPLWVLAYDDYPMTSIPQKQKWQ AFAAEKDAWFIFYHDAEYRALQWEEDGSIKKSVKRMKR*" /label="ytnP CDS" gene complement(2555403..2556173) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /label="ytnP gene" S_feature complement(2556174..2556262) /Source="Nicolas_S_feature" /locus_tag="new_3059402_3059490_c" /HighExp="HiOs, M40t90, T0.30H, T1.30H, T3.0H, T1.0H, Sw, T2.30H, T3.30H, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1145" promotor_-10 complement(2556260..2556279) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2556262) /Source="Nicolas_upshifts" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2556295..2556299) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2556319..2556960) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /EC_number="2.1.1.33" /function="16.6: Maintain" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15789416, 16600901, 17150909, 19934251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15789416, 16600901, 17150909, 19934251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (guanine-N(7)-)-methyltransferase" /protein_id="NP_390868.1" /db_xref="EnsemblGenomes-Gn:BSU29900" /db_xref="EnsemblGenomes-Tr:CAB14968" /db_xref="GOA:O34522" /db_xref="InterPro:IPR003358" /db_xref="InterPro:IPR029063" /db_xref="PDB:2FCA" /db_xref="SubtiList:BG13890" /db_xref="UniProtKB/Swiss-Prot:O34522" /translation="MRMRHKPWADDFLAENADIAISNPADYKGKWNTVFGNDNPIHIE VGTGKGQFISGMAKQNPDINYIGIELFKSVIVTAVQKVKDSEAQNVKLLNIDADTLTD VFEPGEVKRVYLNFSDPWPKKRHEKRRLTYSHFLKKYEEVMGKGGSIHFKTDNRGLFE YSLKSFSEYGLLLTYVSLDLHNSNLEGNIMTEYEEKFSALGQPIYRAEVEWRT*" /label="trmB CDS" gene complement(2556319..2556960) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /label="trmB gene" downshifts complement(2556329) /Source="Nicolas_upshifts" /id="D1541" /incds=0 /nref=46 /ntot=131 /MaxReadThrough="3.31031" /MaxDrop="5.64644" /score="29.2137061" /energy="-10.1" /TU="NA" /idTUdmin="U2321" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(2556394) /Source="Nicolas_upshifts" /id="D1542" /incds=1 /nref=39 /ntot=202 /MaxReadThrough="6.31908" /MaxDrop="3.64275" /score="29.2137061" /energy="-10.1" /TU="U2321,U2323" /idTUdmin="U2323" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2556986..2557005) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2556995) /Source="Nicolas_upshifts" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2556997..2557445) /Source="Nicolas_S_feature" /locus_tag="new_3060225_3060673_c" /HighExp="C30, Cold, G135, G180, B60, Paraq, G150, Oxctl, H2O2, LBGstat" /AntisenseName="ytzH" /AntisenseCor="-0.51149457663808795" /AntisenseRegPval="-18.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1146" promotor_-35 complement(2557021..2557025) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2557104..2557110 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2557125..2557136 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2557132 /Source="Nicolas_upshifts" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="upshifts" CDS 2557167..2557445 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390869.1" /db_xref="EnsemblGenomes-Gn:BSU29910" /db_xref="EnsemblGenomes-Tr:CAB14969" /db_xref="InterPro:IPR025547" /db_xref="SubtiList:BG13942" /db_xref="UniProtKB/Swiss-Prot:O32066" /translation="MGLHYEHQVHLLKDILTDHQLDCCGTVAEYEQLERVIKSLMANT ELDSNFKNVLEDVYRYSQSGISSKSIDSHIQEHQNSLSQWVEQMDSYS*" /label="ytzH CDS" gene 2557167..2557445 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /label="ytzH gene" S_feature 2557446..2557616 /Source="Nicolas_S_feature" /locus_tag="new_3060674_3060844" /HighExp="S5, S7, S8, S6, S4, BT, C30, nit, ferm, G/S" /AntisenseName="ytmP" /AntisenseCor="-0.32108027439793901" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1147" CDS complement(2557446..2558060) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9026440, 11545674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase/phosphotransferase" /protein_id="NP_390870.2" /db_xref="EnsemblGenomes-Gn:BSU29920" /db_xref="EnsemblGenomes-Tr:CAB14970" /db_xref="GOA:C0SPC1" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG13889" /db_xref="UniProtKB/Swiss-Prot:C0SPC1" /translation="MENGDVITAQHWMTGRELKPKDMSGRPVAELLRKIHTSKALLDM LKRLGKEPLNPGALLSQLKQAVFAVQQSSPLIQEGIKYLEEHLHEVHFGEKVVCHCDV NHNNWLLSEDNQLYLIDWDGAMIADPAMDLGPLLYHYVEKPAWESWLSMYGIELTESL RLRMAWYVLSETITFIAWHKAKGNDKEFHDAMEELHILMKRIVD*" /label="ytmP CDS" gene complement(2557446..2558060) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /label="ytmP gene" downshifts 2557594 /Source="Nicolas_upshifts" /id="D1543" /incds=1 /nref=4 /ntot=35 /MaxReadThrough="2.54837" /MaxDrop="3.82368" /score="-4.89809956" /energy="-11.3" /TU="NA" /idTUdmin="U2322" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2558061..2558396) /Source="Nicolas_S_feature" /locus_tag="new_3061289_3061624_c" /HighExp="T1.30H, M9-stat, T2.30H, T3.0H, UNK1, B60, T2.0H, T3.30H, T1.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1148" promotor_-10 complement(2558388..2558407) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2558396) /Source="Nicolas_upshifts" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2558422..2558429) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2558423..2560579) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /EC_number="3.2.1.41" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9453151, 16582490, 19465663, 23973973" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9453151, 16582490, 19465663, 23973973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pullulanase" /protein_id="NP_390871.2" /db_xref="EnsemblGenomes-Gn:BSU29930" /db_xref="EnsemblGenomes-Tr:CAB14971" /db_xref="GOA:C0SPA0" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR011840" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="PDB:2E8Y" /db_xref="PDB:2E8Z" /db_xref="PDB:2E9B" /db_xref="SubtiList:BG12566" /db_xref="UniProtKB/Swiss-Prot:C0SPA0" /translation="MVSIRRSFEAYVDDMNIITVLIPAEQKEIMTPPFRLETEITDFP LAVREEYSLEAKYKYVCVSDHPVTFGKIHCVRASSGHKTDLQIGAVIRTAAFDDEFYY DGELGAVYTADHTVFKVWAPAATSAAVKLSHPNKSGRTFQMTRLEKGVYAVTVTGDLH GYEYLFCICNNSEWMETVDQYAKAVTVNGEKGVVLRPDQMKWTAPLKPFSHPVDAVIY ETHLRDFSIHENSGMINKGKYLALTETDTQTANGSSSGLAYVKELGVTHVELLPVNDF AGVDEEKPLDAYNWGYNPLHFFAPEGSYASNPHDPQTRKTELKQMINTLHQHGLRVIL DVVFNHVYKRENSPFEKTVPGYFFRHDECGMPSNGTGVGNDIASERRMARKFIADCVV YWLEEYNVDGFRFDLLGILDIDTVLYMKEKATKAKPGILLFGEGWDLATPLPHEQKAA LANAPRMPGIGFFNDMFRDAVKGNTFHLKATGFALGNGESAQAVMHGIAGSSGWKALA PIVPEPSQSINYVESHDNHTFWDKMSFALPQENDSRKRSRQRLAAAIILLAQGVPFIH SGQEFFRTKQGVENSYQSSDSINQLDWDRRETFKEDVHYIRRLISLRKAHPAFRLRSA ADIQRHLECLTLKEHLIAYRLYDLDEVDEWKDIIVIHHASPDSVEWRLPNDIPYRLLC DPSGFQEDPTEIKKTVAVNGIGTVILYLASDLKSFA*" /label="amyX CDS" gene complement(2558423..2560579) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /label="amyX gene" Polymorphism join(2560120,2560122) /Source="geneious" /ID="SNP_BsDelta6_3063349_3063349" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=459 /Change="A -> G" /Codon_Change="GTT -> GTC" /Coverage=168 /locus_tag="BSU_29930" /Protein_Effect="None" /Reference_Frequency="1.2%" /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=165 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2560605..2561534) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /EC_number="2.7.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospholipid kinase" /protein_id="NP_390872.1" /db_xref="EnsemblGenomes-Gn:BSU29940" /db_xref="EnsemblGenomes-Tr:CAB14972" /db_xref="GOA:O34799" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13880" /db_xref="UniProtKB/Swiss-Prot:O34799" /translation="MSHWFFIINPTAGHRNGLRVWKSIQKELIKRKVEHRSFLTEHPG HAEVLARQISTIQEYKLKRLIVIGGDGTMHEVVNGLKDVDDIELSFVPAGAYNDFSRG FSIKKIDLIQEIKKVKRPLTRTFHLGSVNFLQDKSQILYFMNHIGIGFDAYVNKKAME FPLRRVFLFLRLRFLVYPLSHLHASATFKPFTLACTTEDETREFHDVWFAVVSNHPFY GGGMKAAPLANPREKTFDIVIVENQPFLKKYWLLCLMAFGKHTKMDGVTMFKAKDITF YTKDKIPFHADGEIMGTTPFRLASSPSPLRIKT*" /label="ytlR CDS" gene complement(2560605..2561534) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /label="ytlR gene" CDS complement(2561583..2562497) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390873.1" /db_xref="EnsemblGenomes-Gn:BSU29950" /db_xref="EnsemblGenomes-Tr:CAB14973" /db_xref="InterPro:IPR012397" /db_xref="SubtiList:BG13879" /db_xref="UniProtKB/Swiss-Prot:O34471" /translation="MAQIIKIHDYISRYELDPYHYINQFVRLKKERWLSLVEAAERQH EERQASAEEPEPVQKRKKFSLKRRKEEIKADIQEERHQWFEDEEDIHVRLPKSRVALA SFYKRHLYDFQLKWASSTLSEISQLSNQVKQDRILRYLTQQLPDSYFIMYKPVLKIQQ AAVELSIVIISPLEIYCVSFLEAEEDSVYIGSKNRFWDKKTASQTASVLNPGLSLFRT DSVVSKIVKEKQAEIPVRKLLLSRTSYIDYPEPPYGLEIADKRSAEEWIERQKKNTAP IKHHQVKAAKALLSYCMSDSYRRQEWLE*" /label="ytlQ CDS" gene complement(2561583..2562497) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /label="ytlQ gene" promotor_-10 complement(2562260..2562278) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2562268) /Source="Nicolas_upshifts" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2562292..2562298) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" CDS complement(2562523..2563074) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /EC_number="3.1.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17012785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA 2',3'-cyclic phosphodiesterase" /protein_id="NP_390874.1" /db_xref="EnsemblGenomes-Gn:BSU29960" /db_xref="EnsemblGenomes-Tr:CAB14974" /db_xref="GOA:O34570" /db_xref="InterPro:IPR004175" /db_xref="InterPro:IPR009097" /db_xref="SubtiList:BG13878" /db_xref="UniProtKB/Swiss-Prot:O34570" /translation="MPDIRPHYFIGVPIPEGIANPIYQAAKNEPILTFQKWVHPLDYH ITLIFLGAADETQIKKLEGSLAEIASEIDPFSIKFGKIDVFGDRRKPRVLHLEPKKNK TLDRLREHTKQAVLQAGFQVEKRPYHPHMTLARKWTGEDGFPAHVPFESGEVSMMAER FSLFQIHLNQSPKYEEIFKFQLS*" /label="ytlP CDS" gene complement(2562523..2563074) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /label="ytlP gene" misc_feature 2562937..2562956 /Source="Nicolas_upshift_promotors" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2562940 /Source="Nicolas_upshifts" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2563097..2563116) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2563109) /Source="Nicolas_upshifts" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2563132..2563135) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" promotor_-35 2563157..2563164 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2563175..2563194 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2563178..2563189) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2563182 /Source="Nicolas_upshifts" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2563192) /Source="Nicolas_upshifts" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2563203..2563209) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2563223..2564158 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cysteine synthase-like enzyme" /protein_id="NP_390875.1" /db_xref="EnsemblGenomes-Gn:BSU29970" /db_xref="EnsemblGenomes-Tr:CAB14975" /db_xref="GOA:O34476" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG13872" /db_xref="UniProtKB/Swiss-Prot:O34476" /translation="MLKIVANTADLIGDTPLVRLNRLQPENAAQVYLKLEFFNPSGSV KDRAAYQMIIEAEQNGLLKPGSVIIEPTSGNTGIGLAMNAAARGYKAILVMPDTMTKE RINLLKAYGAEVVLTPGEERMPGSIKKAKELAEQIPNSYIPMQFDNTANPDAHRKTTA PEIARAIEEIGKPLGAFVASSGTGGTITGTGEALKELFPDITVHVVEPAGSPVLSGGK PGAHKLVGTSPGFIPPILNEDVYDEIIKISDEDAYTTTRRLAAEEGILVGPSSGAACF AAIETAKRLSPDKVVVCMTADTGERYLSTDLWSFI*" /label="ytkP CDS" gene 2563223..2564158 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /label="ytkP gene" downshifts 2564134 /Source="Nicolas_upshifts" /id="D1544" /incds=0 /nref=74 /ntot=225 /MaxReadThrough="2.5873" /MaxDrop="4.59197" /score="29.2734118" /energy="-18.2" /TU="NA" /idTUdmin="U2327" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(2564192..2565583) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /EC_number="3.5.-.-" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7528082, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative promiscuous peptidase/deacylase" /protein_id="NP_390876.1" /db_xref="EnsemblGenomes-Gn:BSU29980" /db_xref="EnsemblGenomes-Tr:CAB14976" /db_xref="GOA:O34944" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010964" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13867" /db_xref="UniProtKB/Swiss-Prot:O34944" /translation="MNWEVEVIRKKEDLIRDTQEFLRINSVMDETTAGPGKPFGEGVN ASLTSLLELGEKEGFTTKNLDGFAGHIEWGEGDDIIGVLCHVDVVPPGDGWTSDPFSA EIRNGRIYARGAIDDKGPTMAAFYALKIVKDMNLPLSKRVRMIIGTDEESDWRCVEHY FKHEEMPTMGFAPDADFPIINAEKGIIDASLLIPHRPNQAEPKAVLVSFQSGLRLNMV PDAAEAVIEGPKNEEILSSFKDMLRTTDQKGEAAIENGQLILRMYGLSCHAMEPNNGI NAGILLCEFLQQTELDDAGKRFVQVVTDKFSGDTRGKKLDIDCEDEISGELTLNVGTL RYKEGQGGELGINIRYPVTAESKVIRDTFESASEFELGEFKDSKPHHVSADHPLVKTL QKVYEGQLGKKADLISIGGGTYARSLKAGVAFGPLFPGRPDSAHQKDEYIEIDDLLRS TALYAQAIYELAK*" /label="ytjP CDS" gene complement(2564192..2565583) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /label="ytjP gene" downshifts complement(2564204) /Source="Nicolas_upshifts" /id="D1545" /incds=0 /nref=63 /ntot=240 /MaxReadThrough="3.38616" /MaxDrop="3.73023" /score="23.9099234" /energy="-14.4" /TU="U2330" /idTUdmin="U2330" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature complement(2565584..2566024) /Source="Nicolas_S_feature" /locus_tag="new_3068812_3069252_c" /HighExp="Etha, Salt, M40t90, Lbtran, T1.30H, M0t90, Lbstat, T1.0H, T0.30H, LBGstat" /AntisenseName="pbuO" /AntisenseCor="-0.324692399913451" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1149" promotor_-35 2565610..2565615 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2565629..2565648 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2565642 /Source="Nicolas_upshifts" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="upshifts" CDS 2565680..2566978 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11591660, 12923093, 15849754, 16850406, 19446032, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12923093, 15849754, 16850406, 19446032, 28583948; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_390877.1" /db_xref="EnsemblGenomes-Gn:BSU29990" /db_xref="EnsemblGenomes-Tr:CAB14977" /db_xref="GOA:O34978" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG13864" /db_xref="UniProtKB/Swiss-Prot:O34978" /translation="MFHLKEQQTSIKQEIIAGLTTFFTMVYIVVVNPVILANAGVPFD QVFTATIIASIVGTLWMALAANYPIAIAPGMGLNAYLAFHVVSASDGGITYATAFSAV FTAGVLFIILSLTPLRKQLIEAIPNNLKYGITTGIGLFIAFIGLRQAGIVAADESNLV TLGNLHSPGVILTLVGLLISVVLMVLNVSGALFIGMAATALIAFFTGQLHFSKGFMSL PHLPEGLMISNPFTAFGDVIHHGLYAVVFSFLLVTIFDTTGTMIGVAEQAGLMKNNKL PNVRKALLADSTATTVGAVFGTSPTTAFIESSAGVAAGGRTGLTALTVAVMFAASMFF SPLVSALSGIAAITSPALIIVGSLMMGSVSNMNWKEMDEAFPAFLVILAMPLTSSIST GIALGFISYPIVKAARGKWREIHPLVIVFAILFFIQLFIL*" /label="pbuO CDS" gene 2565680..2566978 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /label="pbuO gene" promotor_-10 complement(2566001..2566020) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2566024) /Source="Nicolas_upshifts" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2566035..2566041) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2566965 /Source="Nicolas_upshifts" /id="D1546" /incds=0 /nref=43 /ntot=178 /MaxReadThrough="2.37859" /MaxDrop="5.35341" /score="16.9979166" /energy="-10.2" /TU="NA" /idTUdmin="U2329" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2567018..2568175) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390878.1" /db_xref="EnsemblGenomes-Gn:BSU30000" /db_xref="EnsemblGenomes-Tr:CAB14978" /db_xref="GOA:O35029" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG13861" /db_xref="UniProtKB/Swiss-Prot:O35029" /translation="MNGRTLFFRRLFDYYKYQFKVLHAVIDWTVALYIVLPAIAFVIY QYIDLMNGRGLLYEWSEVAEWRWLYAVCVLIMFTGSIRTFLMEADKVFLLQKKEIIYQ LKRYALLYSFLATLAKWLLLFFIVLPLISHSVLITFAESTALLCYLFGLHIFFLSLKQ DRIRKPRSISRWIGDTLVRAILFAGSAILIVFTERHLLALFGILFLFFSVIRSLKKTA SFTAFEAEVTEEKKSRLALAGLVMMMSQEAGMPKVKDRMRRKPLLYRNSKRIFKRRTI CTGYKELFFKVMLRNGEYARQMYMLLSAFTVLIFVSPIWLKVIALLVYTGVCRYILTL IFDKVMDAPFLIGTDKESDEYYRARKSCINILHYAFAACCFLAAAVSLLFT*" /label="ythQ CDS" gene complement(2567018..2568175) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /label="ythQ gene" downshifts complement(2567043) /Source="Nicolas_upshifts" /id="D1547" /incds=0 /nref=1 /ntot=153 /MaxReadThrough="3.07175" /MaxDrop="3.89104" /score="19.8243425" /energy="-11.2" /TU="NA" /idTUdmin="U2332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2567291..2567296 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2567311..2567329 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2567319 /Source="Nicolas_upshifts" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2568172..2568882) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_390879.1" /db_xref="EnsemblGenomes-Gn:BSU30010" /db_xref="EnsemblGenomes-Tr:CAB14979" /db_xref="GOA:O34977" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13860" /db_xref="UniProtKB/Swiss-Prot:O34977" /translation="MTNLLEASIEQAGYTSRKKVLTDVFLEVRKGELVGLIGANGAGK STAIKAILGLSEDFKGHIAWNDCSFAYIPEHPSFYEELTLWEHLDLISTLHGIEESEF AHRAQSLLQTFSLDHVKHELPVTFSKGMQQKLMLIQAFLSKPDMYVIDEPFIGLDPIS TKRFVDMLKAEKERGAGILMCTHVLDTAEKICDRFYMIEKGSLFLQGTLKDVQDKTGL EGQSLLDCFYKAVQGDRL*" /label="ythP CDS" gene complement(2568172..2568882) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /label="ythP gene" promotor_-10 complement(2568896..2568911) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2568913) /Source="Nicolas_upshifts" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2568923..2568932) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2568939..2568940 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2568952..2569057 /Source="Nicolas_S_feature" /locus_tag="new_3072180_3072285" /HighExp="S5, S4, S3, S8, S7, S6, G/S, Pyr, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1150" upshifts 2568952 /Source="Nicolas_upshifts" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2568960..2568970 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2569023..2569029 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2569044..2569063 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2569059..2569172 /Source="Nicolas_S_feature" /locus_tag="new_3072287_3072400" /HighExp="S4, S5, M0t90, S3, Etha, M9-stat, M40t90, LPhT, Heat, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1151" upshifts 2569059 /Source="Nicolas_upshifts" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2569173..2569394 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618461; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (DeoR family)" /protein_id="NP_390880.1" /db_xref="EnsemblGenomes-Gn:BSU30020" /db_xref="EnsemblGenomes-Tr:CAB14980" /db_xref="GOA:O32067" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13939" /db_xref="UniProtKB/Swiss-Prot:O32067" /translation="MKPSTNRMLTRIKSVYMFIQEKGLVTTQELVDEFGITPRTIQRD LNVLAYNDLVHSPSRGKWETTRKKVKITS*" /label="ytzE CDS" gene 2569173..2569394 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /label="ytzE gene" downshifts 2569377 /Source="Nicolas_upshifts" /id="D1548" /incds=0 /nref=166 /ntot=259 /MaxReadThrough="4.38243" /MaxDrop="4.90218" /score="20.9755494" /energy="-13.5" /TU="U2333,U2334" /idTUdmin="U2333" /TUdmin="-54" /isTUend="FALSE" /label="downshifts" downshifts 2569446 /Source="Nicolas_upshifts" /id="D1549" /incds=0 /nref=44 /ntot=172 /MaxReadThrough="-0.189589999999999" /MaxDrop="6.00369" /score="20.9755494" /energy="-13.5" /TU="NA" /idTUdmin="U2334" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2569515..2570234) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /EC_number="4.2.1.70" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11953756, 16511038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA pseudouridylate 516 synthase" /protein_id="NP_390882.2" /db_xref="EnsemblGenomes-Gn:BSU30035" /db_xref="EnsemblGenomes-Tr:CAB14982" /db_xref="GOA:O32068" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG13941" /db_xref="UniProtKB/Swiss-Prot:O32068" /translation="MRLDKLLANSGYGSRKEVKAVVKAGAVMIDGKPAKDVKEHVDPD TQEVTVYGEPVDYREFIYLMMNKPQGVLSATEDSRQQTVVDLLTPEEMRFEPFPAGRL DKDTEGFLLLTNDGQLAHRLLSPKKHVPKTYEVHLKSQISREDISDLETGVYIEGGYK TKPAKAEIKTNDSGNTVIYLTITEGKYHQVKQMAKAVGNEVVYLKRLSMGRVSLDPAL APGEYRELTEEELHLLNEPQA*" /label="rsuA CDS" gene complement(2569515..2570234) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /label="rsuA gene" downshifts complement(2569529) /Source="Nicolas_upshifts" /id="D1550" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="0.79865" /MaxDrop="2.6873" /score="21.6808891" /energy="-13.5" /TU="NA" /idTUdmin="U2335" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2570300) /Source="Nicolas_upshifts" /id="D1551" /incds=0 /nref=1 /ntot=76 /MaxReadThrough="4.50848" /MaxDrop="2.99899" /score="8.79816042" /energy="-9.5" /TU="U2335" /idTUdmin="U2335" /TUdmin="-617" /isTUend="FALSE" /label="downshifts" CDS complement(2570303..2571937) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_390883.1" /db_xref="EnsemblGenomes-Gn:BSU30050" /db_xref="EnsemblGenomes-Tr:CAB14983" /db_xref="GOA:O34674" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG13856" /db_xref="UniProtKB/Swiss-Prot:O34674" /translation="MSSKLLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGALFQY GYNQYTLFLNIATMGFPAAVSKFVSKYNSKGDYETSRKMLKAGMSVMLVTGMIAFFIL YLSAPMFAEISLGGKDNNGLTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPT AVSQVVEQIVRIIFLLSATFLILKVFNGGLVIAVGYATFAALIGAFGGLVVLYIYWNK RKGSLLAMMPNTGPTANLSYKKMFFELFSYAAPYVFVGLAIPLYNYIDTNTFNKAMIE AGHQAISQDMLAILTLYVQKLVMIPVSLATAFGLTLIPTITESFTSGNYKLLNQQINQ TMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPELGANILLWYSPVAILFSLFTVN AAILQGINKQKFAVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIM IKRHAGYSYKILVKRTVLMLVLSAIMGIAVKIVQWVLGFFISYQDGQMQAAIVVVIAA AVGGAVYLYCGYRLGFLQKILGRRLPGFFRKGRHAG*" /label="murJ CDS" gene complement(2570303..2571937) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /label="murJ gene" misc_feature complement(2571969..2571988) /Source="Nicolas_upshift_promotors" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2571985) /Source="Nicolas_upshifts" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2572055..2572059 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2572075..2572094 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2572093 /Source="Nicolas_upshifts" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2572139..2573401 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(FAD)-utilizing dehydrogenase" /protein_id="NP_390884.2" /db_xref="EnsemblGenomes-Gn:BSU30060" /db_xref="EnsemblGenomes-Tr:CAB14984" /db_xref="InterPro:IPR004792" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13850" /db_xref="UniProtKB/Swiss-Prot:Q795R8" /translation="MKQYDVIVIGGGPSGLMAAIAAGEQGAGVLLIDKGNKLGRKLAI SGGGRCNVTNRLPVEEIIKHIPGNGRFLYSAFSEFNNEDIIKFFENLGIQLKEEDHGR MFPVTDKAQSVVDALLNRLKQLRVTIRTNEKIKSVLYEDGQAAGIVTNNGEMIHSQAV IIAVGGKSVPHTGSTGDGYEWAEAAGHTITELFPTEVPVTSGEPFIKQKTLQGLSLRD VAVSVLNKKGKPIITHKMDMLFTHFGLSGPAILRCSQFVVKELKKQPQVPIRIDLYPD INEETLFQKMYKELKEAPKKTIKNVLKPWMQERYLLFLLEKNGISPNVSFSELPKDPF RQFVRDCKQFTVLANGTLSLDKAFVTGGGVSVKEIDPKKMASKKMEGLYFCGEILDIH GYTGGYNITSALVTGRLAGLNAGQYARS*" /label="ytfP CDS" gene 2572139..2573401 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /label="ytfP gene" S_feature 2573402..2573500 /Source="Nicolas_S_feature" /locus_tag="new_3076630_3076728" /HighExp="LBGstat, Lbstat, M0t90, T2.30H, T1.0H, T0.30H, BC, T2.0H, T1.30H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1152" promotor_-35 2573474..2573480 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2573496..2573514 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2573502..2573589 /Source="Nicolas_S_feature" /locus_tag="new_3076730_3076817" /HighExp="Etha, LBGstat, Salt, M9-stat, Lbstat, LBGtran, Sw, C30, Gly, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1153" upshifts 2573502 /Source="Nicolas_upshifts" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2573590..2575128 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14996799, 15849754, 16850406, 8752321, 9925583" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14996799, 15849754, 16850406, 8752321, 9925583; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine transporter" /protein_id="NP_390885.1" /db_xref="EnsemblGenomes-Gn:BSU30070" /db_xref="EnsemblGenomes-Tr:CAB14985" /db_xref="GOA:P54417" /db_xref="InterPro:IPR000060" /db_xref="InterPro:IPR018093" /db_xref="SubtiList:BG11958" /db_xref="UniProtKB/Swiss-Prot:P54417" /translation="MLKHISSVFWIVIAITAAAVLWGVISPDSLQNVSQSAQAFITDS FGWYYLLVVSLFVGFCLFLIFSPIGKIKLGKPDEKPEFGLLSWFAMLFSAGMGIGLVF YGAAEPISHYAISSPSGETETPQAFRDALRYTFFHWGLHAWAIYAIVALCIAYFQFRK GAPGLISSTLSPILGDKVNGPIGKAIDCIAVFATVVGVSTSLGLGATQINGGLNYLFG IPNAFIVQLVLIIIVTVLFLLSAWSGLGKGIKYLSNTNMVLAGLLMLFMLVVGPTVLI MNSFTDSIGQYIQNIVQMSFRLTPNDPEKREWINSWTIFYWAWWISWSPFVGIFIARV SRGRTIREFLIGVLVTPCILTFLWFSIFGVSAMDLQQKGAFNVAKLSTETMLFGTLDH YPLTMVTSILALILIAVFFITSADSATFVLGMQTSYGSLNPANSVKLSWGIIQSAMAA VLLYSGGLAALQNTAILAALPFSIVILLMIASLYQSLSKERREIKKAEKLDKPRSPRV KKAY*" /label="opuD CDS" gene 2573590..2575128 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /label="opuD gene" downshifts 2575108 /Source="Nicolas_upshifts" /id="D1552" /incds=0 /nref=231 /ntot=263 /MaxReadThrough="2.0688" /MaxDrop="6.06429" /score="27.1497809" /energy="-16.3" /TU="NA" /idTUdmin="U2336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2575165..2575347) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8990290" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390886.1" /db_xref="EnsemblGenomes-Gn:BSU30080" /db_xref="EnsemblGenomes-Tr:CAB14986" /db_xref="GOA:P94496" /db_xref="InterPro:IPR020296" /db_xref="SubtiList:BG12339" /db_xref="UniProtKB/Swiss-Prot:P94496" /translation="MLKVAVFDEEHEKDLQTEINSFLKGISEEQLIDIKYTVSAACDP DGEQLYCFSALILYRK*" /label="yteV CDS" gene complement(2575165..2575347) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /label="yteV gene" downshifts complement(2575184) /Source="Nicolas_upshifts" /id="D1553" /incds=0 /nref=10 /ntot=61 /MaxReadThrough="0.597819999999999" /MaxDrop="4.78152" /score="32.507978" /energy="-16.3" /TU="NA" /idTUdmin="U2338" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2575362..2575380) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2575382) /Source="Nicolas_upshifts" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2575396..2575401) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2575415..2576083) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme for rhamnogalaturonan degradation" /protein_id="NP_390887.1" /db_xref="EnsemblGenomes-Gn:BSU30090" /db_xref="EnsemblGenomes-Tr:CAB14987" /db_xref="GOA:O34378" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG13846" /db_xref="UniProtKB/Swiss-Prot:O34378" /translation="MEHDGSLGRMLRFCEWIMRFAYTNLLWLFFTLLGLGVFGIMPAT AALFAVMRKWIQGQDNVPVLKTFWQEYKGEFFRSNLLGAVLALIGVIIYIDLALIYPS HFLLHILRFAIMIFGFLFVSMLFYVFPLLVHFDWKKRLYVKFSLLLSVAYLQYTLTML ALTVALFFLLAYLPGIVPFFSVSLISYCHMRIVYAVLLKVEQHGGEPQRKSHIRKAFY PETR*" /label="rmgU CDS" gene complement(2575415..2576083) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /label="rmgU gene" CDS complement(2576105..2577391) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase of rhamnogalaturonan degradation" /protein_id="NP_390888.1" /db_xref="EnsemblGenomes-Gn:BSU30100" /db_xref="EnsemblGenomes-Tr:CAB14988" /db_xref="GOA:O34371" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13845" /db_xref="UniProtKB/Swiss-Prot:O34371" /translation="MKNIVFCGLSSRAFSMFIKPLMERFSTHYEITGLLDADPKRFAV CKKKFPELAHVPEFSEDAFDEMMRVSKPDIVIVAGRDDTHVAYIVKSLQWNTDVITEK PMVTTVQDANRVLEAEAKSEGKVTVAFNYRYSPFHRKIKEMILDGKIGRVTSVDLNWY IDTYHGASYFKRWNRSRQFSGGLSVHKSTHHFDLVNWWLGQNPEEVFAYGALNYYGPD SEWNPLPEEDGRFCGTCRVKEKCHYYSRWHPRSSKASIKDDHLEAGDQSSLYTAYRPD ACIFDEEIDIEDTYVAAVKYDGGALLSYSIIFSAPYEGYRLTINGTKGRIESNEFHEP SRIPFAFPEQTIEYYPLFESKQTIQVVKNEGGHGGGDPLLLEDLFLGKDPLRRYDILA GAEAGAYSIAVGEGMWRSVAEKKPIGMKELFQMQNV*" /label="rmgT CDS" gene complement(2576105..2577391) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /label="rmgT gene" CDS complement(2577403..2577906) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17449691, 23504016; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein required for rhamnogalaturonan transport and degradation" /protein_id="NP_390889.2" /db_xref="EnsemblGenomes-Gn:BSU30110" /db_xref="EnsemblGenomes-Tr:CAB14989" /db_xref="GOA:C0SP80" /db_xref="SubtiList:BG13844" /db_xref="UniProtKB/Swiss-Prot:C0SP80" /translation="MTKRIRTALCVIVSVLFLASCSSRPDGMHVILFSDMQAGVQEKI KKAAEQNAGKVDIFPAFQEKLLTEITAHEGDVFIVPEDMFQAYDDPENFQPLNGLPPE KTSPYTTVNKKTGEKTIYAVQIEKGKKQLNGYSFQLNRDMAAFIPVYAEKTEEALQLI SQLTEAR*" /label="rmgS CDS" gene complement(2577403..2577906) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /label="rmgS gene" CDS complement(2577903..2579024) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /EC_number="3.2.1.172" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15148314, 15906318, 16781735, 16870154, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15148314, 15906318, 16781735, 16870154, 17449691, 23504016; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="unsaturated rhamnogalacturonyl hydrolase" /protein_id="NP_390890.3" /db_xref="EnsemblGenomes-Gn:BSU30120" /db_xref="EnsemblGenomes-Tr:CAB14990" /db_xref="GOA:O34559" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="PDB:1NC5" /db_xref="PDB:2D8L" /db_xref="PDB:2GH4" /db_xref="SubtiList:BG13843" /db_xref="UniProtKB/Swiss-Prot:O34559" /translation="MGSMDQSIAVKSPLTYAEALANTIMNTYTVEELPPANRWHYHQG VFLCGVLRLWEATGEKRYFEYAKAYADLLIDDNGNLLFRRDELDAIQAGLILFPLYEQ TKDERYVKAAKRLRSLYGTLNRTSEGGFWHKDGYPYQMWLDGLYMGGPFALKYANLKQ ETELFDQVVLQESLMRKHTKDAKTGLFYHAWDEAKKMPWANEETGCSPEFWARSIGWY VMSLADMIEELPKKHPNRHVWKNTLQDMIKSICRYQDKETGLWYQIVDKGDRSDNWLE SSGSCLYMYAIAKGINKGYLDRAYETTLLKAYQGLIQHKTETSEDGAFLVKDICVGTS AGFYDYYVSRERSTNDLHGAGAFILAMTELEPLFRSAGK*" /label="rmgQ CDS" gene complement(2577903..2579024) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /label="rmgQ gene" CDS complement(2579032..2579997) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease for unsaturated rhamnogalacturonan" /protein_id="NP_390892.2" /db_xref="EnsemblGenomes-Gn:BSU30135" /db_xref="EnsemblGenomes-Tr:CAB14992" /db_xref="GOA:C0SPB3" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13841" /db_xref="UniProtKB/Swiss-Prot:C0SPB3" /translation="MKTAEAQAPAVDAVIFKKEKRKRLLIKLIQQKYLYLMILPGCIY FLLFKYVPMWGIVIAFQDYQPFLGILGSEWVGLKHFIRLFTEPTFFLLLKNTLVLFAL NLAIFFPVPILLALLLNEVRIALFKKFVQTLIYIPHFMSWVIVVSLSFVLLTVDGGLI NELIVFFGGEKINFLLNEEWFRPLYILQVIWREAGWSTIIYLAAITAVDPQLYEAAKM DGAGRLRQMWHITLPAIKSVIVVLLILKIGDTLELGFEHVYLLLNATNREVAEIFDTY VYTAGLKQGQFSYSTAVGVFKAAVGLILVMLANRLAKKFGEEGIY*" /label="rmgP CDS" gene complement(2579032..2579997) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /label="rmgP gene" upshifts complement(2580023) /Source="Nicolas_upshifts" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2580024..2580043) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2580058..2580065) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2580153..2580160 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2580173 /Source="Nicolas_upshifts" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2580176..2580195 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2580213..2582531 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="membrane bound transcriptional regulator (controlling rhamnogalacturonan degradation)" /protein_id="NP_390893.1" /db_xref="EnsemblGenomes-Gn:BSU30150" /db_xref="EnsemblGenomes-Tr:CAB14993" /db_xref="GOA:O32071" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG13838" /db_xref="UniProtKB/Swiss-Prot:O32071" /translation="MGGFMKRSQYKFYYKLITFFCLLSTIPVILVGLFSYEHSQKTAI SNVSEEKFDTLQQTQQSIEHILKTVDHSLTHYVSSPPLLRTLSEPLHSDQFQIYNQVN QELNYLQSFDTDLSNMTLVSYTKKWYMNNSGLYRLNTDTLHEAASAYTKQKASRSYWT LEENNHLISTKEGTAENCRYNINLIKQLPLNSTNTKGLAAASIPSCSLVKNMPGYSNA NNLFIIDEKGLIILHNNMSDVGESLHNDGFVQKVLAQTANSGQFETVIDRIHYKVTYQ KSDYNAWTYFSLVSLPELKKEAKSIGWITFAVCLILLTLSLLFSWLGSRHFYKPIRVL YESFARHGAIQEKQQPPQNEFELIEQSFKQLKDRNDDLEETMKQQATHLQQYFMVRLM LGKLTDEEVDNRFESLGLKQNWRHLALLVLQIDTLNHTPYEKKDMDLLLFAVNSLIER NIPTDKHLAPAVVDKQQATILINQSGTKEEFMAELNETARMIQEKAEAELQLSVSIGI SQPFDVLTKAKTAYAEGSEALKYRLKAENKSIIFYEDLDQKKTFKTHFPKQLQHELFD AVKAGDKEKADKCLHAILQAIFTQNTNPYQFQIAIARFLNHVIELMHVLGIELFELEE NKMLYDQIFELKTFEDTENWLKNEFIDPMTDKVNARADAQYKNISDNIIHIIHHEFES ELTLDEIARRLHYNPNYLSSIFKKEMGISFSEYVSSYRHHMAKSWLAETDMAVKDIAE KLKYKNSQNFIRSFKKLEGITPGNYRQQKRSM*" /label="rmgR CDS" gene 2580213..2582531 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /label="rmgR gene" downshifts 2582521 /Source="Nicolas_upshifts" /id="D1554" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="1.43431" /MaxDrop="3.6268" /score="-7.37324741" /energy="-10.2" /TU="NA" /idTUdmin="U2340" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" CDS complement(2582572..2584068) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_390894.3" /db_xref="EnsemblGenomes-Gn:BSU30160" /db_xref="EnsemblGenomes-Tr:CAB14994" /db_xref="GOA:Q795R2" /db_xref="SubtiList:BG13836" /db_xref="UniProtKB/Swiss-Prot:Q795R2" /translation="MGNKWRVLLIVLVLALGGVLAGCKGTDQSSAEGKAGPDSKVKLS WMAILYHQQPPKDRAIKEIEKLTNTELDITWVPDAVKEDRLNAALAAGNLPQIVTIQD IKNSSVMNAFRSGMFWEIGDYIKDYPNLNKMNKLINKNVTIDGKLYGIYRERPLSRQG IVIRKDWLDNLNLKTPKTLDELYEVAKAFTEDDPDKDGKDDTFGLADRNDLIYGAFKT IGSYEGMPTDWKESGGKFTPDFMTQEYKDTMNYMKKLRDNGYMNKDFPVTSKTQQQEL FSQGKAGIYIGNMVDAVNLRDHASDKSMKLEIINRIKGPDGKERVWASGGHNGVFAFP KTSVKTEAELKRILAFFDRIAEEDVYSLMTYGIDGVHYNKGEDKTFTRKESQVKDWQT DIQPLSALIAIDKAYLKNTGDPLRTAYEELTEDNEKIIVSNPAESLYSASESERGDEL KKIIDDATYKYMIGDITESQFDKEVEKWESSGGKQIIQEYEEAFKQAK*" /label="ytcQ CDS" gene complement(2582572..2584068) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /label="ytcQ gene" downshifts complement(2582574) /Source="Nicolas_upshifts" /id="D1555" /incds=0 /nref=26 /ntot=160 /MaxReadThrough="-0.0485899999999999" /MaxDrop="5.21039" /score="6.31011081" /energy="-11.2" /TU="NA" /idTUdmin="U2341" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2584093..2584953) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390895.1" /db_xref="EnsemblGenomes-Gn:BSU30170" /db_xref="EnsemblGenomes-Tr:CAB14995" /db_xref="GOA:P53561" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11788" /db_xref="UniProtKB/Swiss-Prot:P53561" /translation="MKNRLFDMLIYGFLLMFALICVLPFIHVIAASFATVEEVVSKKF ILIPTTFSLDAYRYIFSTDIIYKSLLVSVFVTVIGTAVSMFLSSLMAYGLSRRDLIGR QPLMFLVVFTMLFSGGMIPTFLVVKSLGLLDSYWALILPTAINAFNLIILKNFFQNIP SSLEESAKIDGCNDLGIFFKIVLPLSLPAIATISLFYAVTYWNTYMTAILYLNDSAKW PIQVLLRQIVIVSSGMQGDMSEMGSGSPPPEQTIKMAVIVVATIPVLLVYPFIQKHFA KGALLGSVKG*" /label="ytcP CDS" gene complement(2584093..2584953) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /label="ytcP gene" promotor_-10 complement(2585029..2585048) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2585038) /Source="Nicolas_upshifts" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2585064..2585071) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2585160..2585921) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-dependent nucleoside-diphosphate-sugar epimerase" /protein_id="NP_390896.2" /db_xref="EnsemblGenomes-Gn:BSU30180" /db_xref="EnsemblGenomes-Tr:CAB14996" /db_xref="GOA:P53560" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11787" /db_xref="UniProtKB/Swiss-Prot:P53560" /translation="MKKVLIAGGNGVIGRLLAEGLISDYEVTVLDKDHFDGKASSIQA DAANYEELLKKIPKDTDAILNLLAVKIKYDIMDIAEFEKMTDVFYRASYYLCRAAAEL GIQKLVFASSNHVTDVYEKDGRSLLGREITTSDYPLSKNLYGVLKLTSEQIGHLFYLE NKLSVINLRIGTVVTDEMDTLHEKERTKKTLLSHPDLLSIFKAAIETNIRYGTYYAVS DNPGRPWSIESAVNELGFSPQINTAELLNEEENGA*" /label="ytbQ CDS" gene complement(2585160..2585921) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /label="ytbQ gene" downshifts complement(2585189) /Source="Nicolas_upshifts" /id="D1556" /incds=0 /nref=153 /ntot=196 /MaxReadThrough="1.18543" /MaxDrop="5.85654" /score="12.3836957" /energy="-11.1" /TU="NA" /idTUdmin="U2344" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2585922..2585997) /Source="Nicolas_S_feature" /locus_tag="new_3089150_3089225_c" /HighExp="LPh, HPh, aero, Gly, HiOs, BMM, GM-0.1, GM 10, GM 15, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1154" CDS complement(2585998..2587185) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /EC_number="1.14.14.46" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 for pimelic acid formation for biotin biosynthesis" /protein_id="NP_390897.1" /db_xref="EnsemblGenomes-Gn:BSU30190" /db_xref="EnsemblGenomes-Tr:CAB14997" /db_xref="GOA:P53554" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:3EJB" /db_xref="PDB:3EJD" /db_xref="PDB:3EJE" /db_xref="SubtiList:BG11528" /db_xref="UniProtKB/Swiss-Prot:P53554" /translation="MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTG YEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTP RTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKE WAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKD KLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECL RYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNP HLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPV TFE*" /label="bioI CDS" gene complement(2585998..2587185) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /label="bioI gene" CDS complement(2587254..2588261) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /EC_number="2.8.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin synthase" /protein_id="NP_390898.1" /db_xref="EnsemblGenomes-Gn:BSU30200" /db_xref="EnsemblGenomes-Tr:CAB14998" /db_xref="GOA:P53557" /db_xref="InterPro:IPR002684" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010722" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024177" /db_xref="SubtiList:BG11525" /db_xref="UniProtKB/Swiss-Prot:P53557" /translation="MNQWMELADRVLAGAEVTDEEALSILHCPDEDILLLMHGAFHIR KHFYGKKVKLNMIMNAKSGLCPENCGYCSQSAISKAPIESYRMVNKETLLEGAKRAHD LNIGTYCIVASGRGPSNREVDQVVDAVQEIKETYGLKICACLGLLKPEQAKRLKDAGV DRYNHNLNTSQRNHSNITTSHTYDDRVNTVEIAKESGLSPCSGAIIGMKETKQDVIDI AKSLKALDADSIPVNFLHAIDGTPLEGVNELNPLYCLKVLALFRFINPSKEIRISGGR EVNLRTLQPLGLYAANSIFVGDYLTTAGQEETEDHKMLSDLGFEVESVEEMKASLSAK S*" /label="bioB CDS" gene complement(2587254..2588261) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /label="bioB gene" CDS complement(2588264..2588959) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /EC_number="6.3.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242, 20565114" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242, 20565114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dethiobiotin synthetase" /protein_id="NP_390899.1" /db_xref="EnsemblGenomes-Gn:BSU30210" /db_xref="EnsemblGenomes-Tr:CAB14999" /db_xref="GOA:P53558" /db_xref="InterPro:IPR004472" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11526" /db_xref="UniProtKB/Swiss-Prot:P53558" /translation="MRGFFVTGTDTEVGKTVISSGLAALLKDNNRHVGVYKPFLSGIS RHHPDSDTSLLKDMSQTSLSHEDITPFAFKAPLAPYVAGKLEGKTVTMEEVLSHWGRI REKHECFIVEGAGGISVPLGEDYLVSHVIKALQLPMIIVARPRLGTINHTFLTVKYAE SMGLPIAGIIINGISDSPDEDEKTNPEMIERLCGVPILGVTPKLANVTKETVLHMVKD HINLSLLMNQVGV*" /label="bioD CDS" gene complement(2588264..2588959) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /label="bioD gene" CDS complement(2588956..2590125) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11322938, 11717296, 12368242, 15056910, 16557306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11322938, 11717296, 12368242, 15056910, 16557306; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="8-amino-7-oxononanoate synthase (pimeloyl-CoA-dependent)" /protein_id="NP_390900.1" /db_xref="EnsemblGenomes-Gn:BSU30220" /db_xref="EnsemblGenomes-Tr:CAB15000" /db_xref="GOA:P53556" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11527" /db_xref="UniProtKB/Swiss-Prot:P53556" /translation="MKIDSWLNERLDRMKEAGVHRNLRSMDGAPVPERNIDGENQTVW SSNNYLGLASDRRLIDAAQTALQQFGTGSSGSRLTTGNSVWHEKLEKKIASFKLTEAA LLFSSGYLANVGVLSSLPEKEDVILSDQLNHASMIDGCRLSKADTVVYRHIDMNDLEN KLNETQRYQRRFIVTDGVFSMDGTIAPLDQIISLAKRYHAFVVVDDAHATGVLGDSGQ GTSEYFGVCPDIVIGTLSKAVGAEGGFAAGSAVFIDFLLNHARTFIFQTAIPPASCAA AHEAFNIIEASREKRQLLFSYISMIRTSLKNMGYVVKGDHTPIIPVVIGDAHKTVLFA EKLQGKGIYAPAIRPPTVAPGESRIRITITSDHSMGDIDHLLQTFHSIGKELHII*" /label="bioFC CDS" gene complement(2588956..2590125) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /label="bioFC gene" promotor_-35 2588992..2588999 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2589014..2589033 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2589032 /Source="Nicolas_upshifts" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2590115..2591461) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /EC_number="2.6.1.105" /function="4.1: Biotin" /experiment="publication(s) with functional evidences, PMID:15880481, 20565114, 21437340" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15880481, 20565114, 21437340; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lysine-8-amino-7-oxononanoate aminotransferase" /protein_id="NP_390901.1" /db_xref="EnsemblGenomes-Gn:BSU30230" /db_xref="EnsemblGenomes-Tr:CAB15001" /db_xref="GOA:P53555" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR005815" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3DOD" /db_xref="PDB:3DRD" /db_xref="PDB:3DU4" /db_xref="SubtiList:BG11524" /db_xref="UniProtKB/Swiss-Prot:P53555" /translation="MTHDLIEKSKKHLWLPFTQMKDYDENPLIIESGTGIKVKDINGK EYYDGFSSVWLNVHGHRKKELDDAIKKQLGKIAHSTLLGMTNVPATQLAETLIDISPK KLTRVFYSDSGAEAMEIALKMAFQYWKNIGKPEKQKFIAMKNGYHGDTIGAVSVGSIE LFHHVYGPLMFESYKAPIPYVYRSESGDPDECRDQCLRELAQLLEEHHEEIAALSIES MVQGASGMIVMPEGYLAGVRELCTTYDVLMIVDEVATGFGRTGKMFACEHENVQPDLM AAGKGITGGYLPIAVTFATEDIYKAFYDDYENLKTFFHGHSYTGNQLGCAVALENLAL FESENIVEQVAEKSKKLHFLLQDLHALPHVGDIRQLGFMCGAELVRSKETKEPYPADR RIGYKVSLKMRELGMLTRPLGDVIAFLPPLASTAEELSEMVAIMKQAIHEVTSLED*" /label="bioK CDS" gene complement(2590115..2591461) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /label="bioK gene" promotor_-35 2590531..2590535 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2590550 /Source="Nicolas_upshifts" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2590551..2590569 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2591451..2592227) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /EC_number="6.2.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11368323, 11717296, 21437340, 28196402, 29054876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11368323, 11717296, 21437340, 28196402, 29054876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-carboxyhexanoate-CoA ligase (pimeloyl-CoA synthase)" /protein_id="NP_390902.3" /db_xref="EnsemblGenomes-Gn:BSU30240" /db_xref="EnsemblGenomes-Tr:CAB15002" /db_xref="GOA:P53559" /db_xref="InterPro:IPR005499" /db_xref="PDB:5FLG" /db_xref="PDB:5FLL" /db_xref="PDB:5FM0" /db_xref="PDB:5G1F" /db_xref="SubtiList:BG11529" /db_xref="UniProtKB/Swiss-Prot:P53559" /translation="MQEETFYSVRMRASMNGSHEDGGKHISGGERLIPFHEMKHTVNA LLEKGLSHSRGKPDFMQIQFEEVHESIKTIQPLPVHTNEVSCPEEGQKLARLLLEKEG VSRDVIEKAYEQIPEWSDVRGAVLFDIHTGKRMDQTKEKGVRVSRMDWPDANFEKWAL HSHVPAHSRIKEALALASKVSRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKE YGTEEGCRVFFIDGSNDVNTYIHDLEKQPILIEWEEDHDS*" /label="bioW CDS" gene complement(2591451..2592227) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /label="bioW gene" S_feature complement(2592228..2592320) /Source="Nicolas_S_feature" /locus_tag="new_3095456_3095548_c" /HighExp="T-5.40H, GM 60, LPh, GM 25, HPh, MG 120, M9-exp, BMM, GM 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1155" promotor_-10 complement(2592306..2592325) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2592320) /Source="Nicolas_upshifts" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2592340..2592347) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2592437..2593336) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390903.1" /db_xref="EnsemblGenomes-Gn:BSU30250" /db_xref="EnsemblGenomes-Tr:CAB15003" /db_xref="GOA:O34973" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11786" /db_xref="UniProtKB/Swiss-Prot:O34973" /translation="MRAERRKQLFRLLGDLPDRRPISVETLRIEEREENIVETLLLDL NGHEKAPAYFVKPKKTEGPCPAVLFQHSHGGQYDRGKSELIEGADYLKTPSFSDELTS LGYGVLAIDHWGFGDRRGKAESEIFKEMLLTGKVMWGMMIYDSLSALDYMQSRSDVQP DRIGTIGMSMGGLMAWWTAALDDRIKVCVDLCSQVDHHVLIKTQNLDRHGFYYYVPSL AKHFSASEIQSLIAPRPHLSLVGVHDRLTPAEGVDKIEKELTAVYAGQGAADCYRVVR SASGHFETAVIRHEAVRFLQKWL*" /label="ytaP CDS" gene complement(2592437..2593336) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /label="ytaP gene" promotor_-10 complement(2593359..2593377) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2593376) /Source="Nicolas_upshifts" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2593388..2593396) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2593466..2593473 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2593489..2593508 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2593495 /Source="Nicolas_upshifts" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2593554..2594588 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12847288; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_390904.1" /db_xref="EnsemblGenomes-Gn:BSU30260" /db_xref="EnsemblGenomes-Tr:CAB15004" /db_xref="GOA:O34829" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12626" /db_xref="UniProtKB/Swiss-Prot:O34829" /translation="MVRIKDIALKAKVSSATVSRILNEDESLSVAGETRQRVINIAEE LGYQTVAKRRKSRGQKQRAQPLIGVLSCLSPDQERQDPYFSSIRKGIEKECFEQEIFI TNSIHLGSFQEHIFRELDGVIVIGRVHDEAVKHISGRLEHAVFINHSPDPQAYDSIGI DFESASRQAIDHLFDLGYKRLGYIGGQEKEHTLKDGQSIRRTIEDKRLTAFLESAAPQ PEHVLIGEYSMREGYRLMKKAIDQGHLPEAFFIASDSMAIGALKALQEAGLQVPRDTA IVSFNGIEEAEFASTPLTTVKVYTEEMGRTGVKLLLDRLNGRTLPQHVTLPTTLIVRQ SCGCTAKEVT*" /label="msmR CDS" gene 2593554..2594588 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /label="msmR gene" promotor_-35 2594537..2594544 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2594559..2594567 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2594576 /Source="Nicolas_upshifts" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2594622..2595902 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8449892, 12847288, 16707683, 18954360, 28036052; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="multiple sugar-binding lipoprotein" /protein_id="NP_390905.1" /db_xref="EnsemblGenomes-Gn:BSU30270" /db_xref="EnsemblGenomes-Tr:CAB15005" /db_xref="GOA:O34335" /db_xref="InterPro:IPR006059" /db_xref="PDB:4R6H" /db_xref="SubtiList:BG12625" /db_xref="UniProtKB/Swiss-Prot:O34335" /translation="MKHTFVLFLSLILLVLPGCSAEKSSADTAKKTLTIYSTMSTDSE RDTFRKLAAAFEKEHSDIHVSLHFPGNDYENMMRVRMAANDLPDLFDTHGWGKIRYGE YTADLRDMKWTQDLDPNLNSILKNKSGKVYAYPINQAKDGLAYNRNILDRYGIAPPET MDDFIKALRTIKEKSKGSIVPFWFAGYDKSSFAQYYDQFATPLLITDPAHNEKKQLIN GTFQWSKFTYLSEILKQMQKEKLINIDAVTAKKSQLIELMAQNKIAFTMQGGTLGQDV AQINPNVKVGIIPTPAIHPGDDPIWIGGERYTLAAWKDSPQLKEAKDFIAFMARPANA KQMAEATSLPSGLTNVKADIFYANDYEYYQDVKVEPYFDRLYLPNGMWDVLGTVGQEL AADILAPQDISQKLGREYKRLREQSETQGAENNE*" /label="msmE CDS" gene 2594622..2595902 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /label="msmE gene" CDS 2595895..2596806 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 12847288, 15849754, 16707683, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="carbohydrate ABC transporter (permease)" /protein_id="NP_390906.1" /db_xref="EnsemblGenomes-Gn:BSU30280" /db_xref="EnsemblGenomes-Tr:CAB15006" /db_xref="GOA:O34706" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12565" /db_xref="UniProtKB/Swiss-Prot:O34706" /translation="MSEIARDVHVKQVKPKKQSSLWWMYIPALLSVLVFMIYPFVKGT LITFTNWNGFSQVYQWVGFAQYERLFSDPDTWHILKNTLHYGLGSTFFQNVVGLLYAL LLNQSIKTKAVTRTIVYLPVMISPLIMGYIWYFFFSYDGGALNDLLGVFGISPINALA SPSLNPWIIVMINTYQYVGIAMVVYLAGLQSIPKDYYEAAQMDGAKQGQQFFTITLPL LMPSITINIVINIIGGLKLFDVIIALTAGGPGNASQSMSTFMYDLYFKRQDAGYAATQ GIFMAFVILIISFCALAYFKRKETEMS*" /label="msmF CDS" gene 2595895..2596806 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /label="msmF gene" CDS 2596803..2597633 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 15849754, 16707683, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="maltose and multiple sugars ABC transporter (permease)" /protein_id="NP_390907.1" /db_xref="EnsemblGenomes-Gn:BSU30290" /db_xref="EnsemblGenomes-Tr:CAB15007" /db_xref="GOA:O34518" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12564" /db_xref="UniProtKB/Swiss-Prot:O34518" /translation="MRAARTKSMRIITLLAAIVACAHFIPFYILLTTSLKAKGDYSSK WIFPADISFHNFSEAWERASLGNSFINTMIITGFSALLLIIFGSLAAYPLARRETKLN KAVFALLISIMIIPPLTSMVPLYRMVVDAGMVNTHAIAIFINTAAYMPLTVFLYSGFI RSTIPKELVEAARIDGAGMLKIFFTIVFPLLKPITATICIISCVFIWNDYQFAIFFLQ DQKVQTLTVAMAGFFGENANNLHLVAAAALMAMLPMVVLFLALQKYFIAGLSSGAVKG *" /label="msmG CDS" gene 2596803..2597633 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /label="msmG gene" promotor_-35 2597606..2597610 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2597626..2597645 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2597634 /Source="Nicolas_upshifts" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2597653..2598951 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /EC_number="3.2.1.22" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12847288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-D-galactoside galactohydrolase" /protein_id="NP_390908.1" /db_xref="EnsemblGenomes-Gn:BSU30300" /db_xref="EnsemblGenomes-Tr:CAB15008" /db_xref="GOA:O34645" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12615" /db_xref="UniProtKB/Swiss-Prot:O34645" /translation="MKKITFIGAGSTIFAKNVLGDCLLTEALNGFEFALYDIDPKRLQ ESQLMLENLRDRYNPSVAINSYDDRKLALQNAGYVINAIQVGGYKPSTVIDFEIPKRY GLRQTIADTVGIGGIFRSLRTIPVLFDIAKDMEEMCPDAWFLNYTNPMATLTGAMLRY TNIKTIGLCHSVQVCTKDLFKALGMEHDGIEERIAGINHMAWLLEVKKDGTDLYPEIK RRAKEKQKTKHHDMVRFELMDKFGYYVTESSEHNAEYHPYFIKRNYPELISELQIPLD EYPRRCVKQIENWEKMRDDIVNNKNLTHERSKEYGSRIIEAMETNEPFTFGGNVLNTG LITNLPSKAVVEVTCVADRKKITPCFAGELPEQLAALNRTNINTQLMTIEAAVTRKKE AVYQAAMLDPHTSAELSMKDIISMCDDLFAAHGDWLPEYK*" /label="melA CDS" gene 2597653..2598951 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /label="melA gene" downshifts 2598932 /Source="Nicolas_upshifts" /id="D1557" /incds=0 /nref=12 /ntot=55 /MaxReadThrough="3.99614" /MaxDrop="3.96455" /score="26.0469828" /energy="-11.9" /TU="NA" /idTUdmin="U2346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2598973..2599284) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /EC_number="2.8.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390909.2" /db_xref="EnsemblGenomes-Gn:BSU30310" /db_xref="EnsemblGenomes-Tr:CAB15009" /db_xref="GOA:O32072" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG13932" /db_xref="UniProtKB/Swiss-Prot:O32072" /translation="MEIKEISTAALKEKIEADEELYLIDVREDEEVAEGMIPQAVHIR MGDIPEKMETLDKDKEYVFICRSGMRSMNVCKYLDEQGFKTVNVEGGMMAWEGETKPK N*" /label="ytwF CDS" gene complement(2598973..2599284) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /label="ytwF gene" downshifts complement(2598984) /Source="Nicolas_upshifts" /id="D1558" /incds=0 /nref=84 /ntot=254 /MaxReadThrough="2.71726" /MaxDrop="5.77228" /score="23.1306393" /energy="-11.9" /TU="NA" /idTUdmin="U2349" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2599308..2599327) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2599316) /Source="Nicolas_upshifts" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2599342..2599349) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2599350 /Source="Nicolas_upshifts" /id="D1559" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="0.749090000000001" /MaxDrop="4.59307" /score="20.1681452" /energy="-11.2" /TU="NA" /idTUdmin="U2346" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS complement(2599401..2601815) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /EC_number="6.1.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1317842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="leucyl-tRNA synthetase" /protein_id="NP_390910.1" /db_xref="EnsemblGenomes-Gn:BSU30320" /db_xref="EnsemblGenomes-Tr:CAB15010" /db_xref="GOA:P36430" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002302" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR025709" /db_xref="SubtiList:BG10676" /db_xref="UniProtKB/Swiss-Prot:P36430" /translation="MSFQHKEIEKKWQTYWLENKTFATLDNNEKQKFYALDMFPYPSG AGLHVGHPEGYTATDILSRMKRMQGYDVLHPMGWDAFGLPAEQYALDTGNDPAVFTKQ NIDNFRRQIQALGFSYDWDREINTTDPEYYKWTQWIFLKLYEKGLAYVDEVPVNWCPA LGTVLANEEVIDGKSERGGHPVERRPMKQWMLKITAYADRLLEDLEELDWPESIKDMQ RNWIGRSEGAHVHFAIDGHDDSFTVFTTRPDTLFGATYTVLAPEHALVENITTAEQKE AVEAYIKEIQSKSDLERTDLAKTKTGVFTGAYAINPVNGEKLPIWIADYVLASYGTGA VMAVPGHDERDFEFAKTFGLPVKEVVKGGNVEEAAYTGDGEHVNSDFLNGLHKQEAIE KVIAWLEETKNGEKKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTSTAVPEEELPLILP KTDEIKPSGTGESPLANIKEWVEVTDPETGKKGRRETNTMPQWAGSCWYFLRYIDPHN PDQLASPEKLEKWLPVDMYIGGAEHAVLHLLYARFWHKFLYDIGVVPTKEPFQKLYNQ GMILGENNEKMSKSKGNVVNPDEIVASHGADTLRLYEMFMGPLDASIAWSESGLDGAR RFLDRVWRLFIEDSGELNGKIVEGAGETLERVYHETVMKVTDHYEGLRFNTGISQLMV FINEAYKATELPKEYMEGFVKLLSPVAPHLAEELWEKLGHSGTIAYEAWPVYDETKLV DDEVEIVVQLNGKVKAKLQVPADATKEQLEQLAQADEKVKEQLEGKTIRKIIAVPGKL VNIVAN*" /label="leuS CDS" gene complement(2599401..2601815) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /label="leuS gene" downshifts complement(2599405) /Source="Nicolas_upshifts" /id="D1560" /incds=0 /nref=115 /ntot=224 /MaxReadThrough="3.2803" /MaxDrop="4.46738" /score="33.3300042" /energy="-11.2" /TU="U2350" /idTUdmin="U2350" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" S_feature complement(2601816..2601911) /Source="Nicolas_S_feature" /locus_tag="new_3105044_3105139_c" /HighExp="G150, G180, G135, LBGexp, HPh, LBGtran, Paraq, Lbexp, H2O2, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.989" /label="S1156" misc_RNA complement(2601925..2602139) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /product="T-box riboswitch specific of leucine tRNA ligase" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201, 27169680; Product type n: RNA" /function="16.3: Control" /label="tboL RNA" gene complement(2601925..2602139) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /label="tboL gene" downshifts complement(2601956) /Source="Nicolas_upshifts" /id="D1561" /incds=0 /nref=8 /ntot=38 /MaxReadThrough="6.86098" /MaxDrop="4.90189" /score="40.6873438" /energy="-16.7" /TU="U2350" /idTUdmin="U2352" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2602151..2602170) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2602172) /Source="Nicolas_upshifts" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2602176..2602181 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2602185..2602190) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2602197..2602215 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2602210..2602650 /Source="Nicolas_S_feature" /locus_tag="new_3105438_3105878" /HighExp="S4, S5, S3, S8, S7, S6, T5.0H, LoTm, C30, M9-stat" /AntisenseName="ytvB" /AntisenseCor="0.57398798861917499" /AntisenseRegPval="-24.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1157" upshifts 2602210 /Source="Nicolas_upshifts" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2602242..2602577) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16923906; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein" /protein_id="NP_390911.3" /db_xref="EnsemblGenomes-Gn:BSU30330" /db_xref="EnsemblGenomes-Tr:CAB15011" /db_xref="GOA:O34881" /db_xref="InterPro:IPR025353" /db_xref="SubtiList:BG13929" /db_xref="UniProtKB/Swiss-Prot:O34881" /translation="MKMLHQVLIACVIGGIMGILGHVKKRGRLEKPRMTKRFIYLGFL EDWFIGMTASILLVLSADPDSGIQLVILSIISGYGGEAVLRSFDFVRELNSGGEPAES KRQTKTPPE*" /label="ytvB CDS" gene complement(2602242..2602577) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /label="ytvB gene" S_feature complement(2602572..2602836) /Source="Nicolas_S_feature" /locus_tag="new_3105800_3106064_c" /HighExp="S6, S8, S7, Etha, S5, M9-stat, B60, BT, B36, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1158" promotor_-10 complement(2602821..2602840) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-10" upshifts complement(2602836) /Source="Nicolas_upshifts" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="upshifts" promotor_-35 complement(2602855..2602862) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-35" promotor_-35 2602875..2602882 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2602896..2602915 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2602912 /Source="Nicolas_upshifts" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2602914..2602981 /Source="Nicolas_S_feature" /locus_tag="new_3106142_3106209" /HighExp="M40t90, Etha, dia5, HiOs, dia15, H2O2, BC, Diami, M0t90, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1159" CDS 2602982..2603767 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="blue light GTP-binding receptor" /protein_id="NP_390912.1" /db_xref="EnsemblGenomes-Gn:BSU30340" /db_xref="EnsemblGenomes-Tr:CAB15012" /db_xref="GOA:O34627" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036513" /db_xref="PDB:1IUM" /db_xref="PDB:2MWG" /db_xref="PDB:2PR5" /db_xref="PDB:2PR6" /db_xref="PDB:4GCZ" /db_xref="SubtiList:BG13928" /db_xref="UniProtKB/Swiss-Prot:O34627" /translation="MASFQSFGIPGQLEVIKKALDHVRVGVVITDPALEDNPIVYVNQ GFVQMTGYETEEILGKNCRFLQGKHTDPAEVDNIRTALQNKEPVTVQIQNYKKDGTMF WNELNIDPMEIEDKTYFVGIQNDITKQKEYEKLLEDSLTEITALSTPIVPIRNGISAL PLVGNLTEERFNSIVCTLTNILSTSKDDYLIIDLSGLAQVNEQTADQIFKLSHLLKLT GTELIITGIKPELAMKMNKLDANFSSLKTYSNVKDAVKVLPIM*" /label="blrA CDS" gene 2602982..2603767 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /label="blrA gene" S_feature 2603768..2603824 /Source="Nicolas_S_feature" /locus_tag="new_3106996_3107052" /HighExp="Sw, M40t90, BC, Etha, dia5, dia15, H2O2, Mt0, M0t90, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1160" CDS complement(2604004..2605197) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390913.1" /db_xref="EnsemblGenomes-Gn:BSU30350" /db_xref="EnsemblGenomes-Tr:CAB15013" /db_xref="GOA:O34546" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13925" /db_xref="UniProtKB/Swiss-Prot:O34546" /translation="MPRALKILVIGMFINVTGASFLWPLNTIYIHNHLGKSLTVAGLV LMLNSGASVAGNLCGGFLFDKIGGFKSIMLGIAITLASLMGLVFFHDWPAYIVLLTIV GFGSGVVFPASYAMAGSVWPEGGRKAFNAIYVAQNAGVAVGSALGGVVASFSFSYVFL ANAVLYLIFFFIVYFGFRNIQTGDASQTSVLDYDAVNSKAKFAALIILSGGYVLGWLA YSQWSTTIASYTQSIGISLSLYSVLWTVNGILIVLGQPLVSFVVKKWAESLKAQMVIG FIIFIVSFSMLLTAKQFPMFLAAMVILTIGEMLVWPAVPTIANQLAPKGKEGFYQGFV NSAATGGRMIGPLFGGVLVDHYGIRALVLSLLVLLLISIATTLLYDKRIKSAKETNKQ ASISS*" /label="yttB CDS" gene complement(2604004..2605197) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /label="yttB gene" downshifts complement(2604024) /Source="Nicolas_upshifts" /id="D1562" /incds=0 /nref=5 /ntot=47 /MaxReadThrough="2.03991" /MaxDrop="3.41948" /score="-7.70376219" /energy="-9.4" /TU="NA" /idTUdmin="U2354" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2605198..2605296) /Source="Nicolas_S_feature" /locus_tag="new_3108426_3108524_c" /HighExp="dia15, LBGstat, H2O2, G180, LPhT, Paraq, Oxctl, G150, G135, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1161" promotor_-10 complement(2605277..2605296) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2605296) /Source="Nicolas_upshifts" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2605310..2605317) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2605334..2605337 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2605352..2605371 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2605356 /Source="Nicolas_upshifts" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="upshifts" CDS 2605386..2606132 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390914.2" /db_xref="EnsemblGenomes-Gn:BSU30360" /db_xref="EnsemblGenomes-Tr:CAB15014" /db_xref="GOA:Q795Q5" /db_xref="InterPro:IPR006876" /db_xref="InterPro:IPR035451" /db_xref="SubtiList:BG13924" /db_xref="UniProtKB/Swiss-Prot:Q795Q5" /translation="MEMVLAFLGFLACLIALGYGLYHLVRYVLKKEKRFSKRLFWPLF IGGLVLLFTGAALAEPDTAAANAEKKYSALNAEYKNLTKEHEELEKEYKSVSSEAKKL KDNKEDQDKLEKLKNENSDLKKTQKSLKAEIKELQENQKQLKEDAKTAKAENETLRQD KTKLENQLKETESQTASSHEDTGSSSNNTSKSDETKTADKAEGCNIKGSRNGIYHTPG STYYDRTTDPAEMFCSVEEAEAAGYRAPKR*" /label="yttA CDS" gene 2605386..2606132 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /label="yttA gene" downshifts 2606027 /Source="Nicolas_upshifts" /id="D1563" /incds=1 /nref=2 /ntot=94 /MaxReadThrough="4.11368" /MaxDrop="3.01036" /score="23.2955589" /energy="-11.6" /TU="U2355" /idTUdmin="U2355" /TUdmin="-99" /isTUend="FALSE" /label="downshifts" downshifts 2606126 /Source="Nicolas_upshifts" /id="D1564" /incds=0 /nref=31 /ntot=169 /MaxReadThrough="1.73994" /MaxDrop="4.19129" /score="23.2955589" /energy="-11.6" /TU="NA" /idTUdmin="U2355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2606169..2608109) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612242, 15849754, 16850406, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 15849754, 16850406, 17905982, 25118291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease)" /protein_id="NP_390915.1" /db_xref="EnsemblGenomes-Gn:BSU30370" /db_xref="EnsemblGenomes-Tr:CAB15015" /db_xref="GOA:O34741" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG13921" /db_xref="UniProtKB/Swiss-Prot:O34741" /translation="MNINQLILRNLKKNLRNYYLYVFALIFSVALYFAFVTLQYDPAI NEVKASIKGAAAIKTASILLVAVVAIFILYANTIFIKRRSKEIGLFQLIGMTKHKIFR ILSAENVMLYFGSLAIGVAAGFSISKLVLMILFKIVDVKADAKLHFSEQALVQTVIVF CGIYLLIMIMNYTFIKKQSILSLFKVTSSTEDKVKKISFFQMLIGALGIVLILTGYYV SSELFGGKFKTINELFVAMSFILGSVIIGTFLFYKGSVTFISNIIRKSKGGYLNISEV LSLSSIMFRMKSNALLLTIITTVSALAIGLLSLAYISYYSSEKTAEQNVAADFSFMNE KDAKLFENKLRESNISFVKKATPVLQANVDIANIMDGTPKEMQGDPGNMQLAVVSDKD VKGVDVAAGEAVFSGYTDLLQKIMVFKDSGVIKVKSKHETQPLKYKGLREEFLVSYTF TSGGMPAVIVDDSLFKQLDKDKDPRIQLAQSTFIGVNVKHDDQMEKANELFQQVNKKN EHLSRLDTSAAQKSLFGMVMFIVGFLGLTFLITSGCILYFKQMGESEDEKPSYTILRK LGFTQGDLIKGIRIKQMYNFGIPLVVGLFHSYFAVQSGWFLFGSEVWAPMIMVMVLYT ALYSIFGFLSVLYYKKVIKSSL*" /label="bceB CDS" gene complement(2606169..2608109) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /label="bceB gene" downshifts complement(2606180) /Source="Nicolas_upshifts" /id="D1565" /incds=0 /nref=13 /ntot=89 /MaxReadThrough="1.56566" /MaxDrop="4.45006" /score="29.4802229" /energy="-11.6" /TU="NA" /idTUdmin="U2356" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2608099..2608860) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14612242, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 17905982, 25118291; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacitracin ABC efflux transporter (ATP-binding protein)" /protein_id="NP_390916.1" /db_xref="EnsemblGenomes-Gn:BSU30380" /db_xref="EnsemblGenomes-Tr:CAB15016" /db_xref="GOA:O34697" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13920" /db_xref="UniProtKB/Swiss-Prot:O34697" /translation="MVILEANKIRKSYGNKLNKQEVLKGIDIHIEKGEFVSIMGASGS GKTTLLNVLSSIDQVSHGTIHINGNDMTAMKEKQLAEFRKQHLGFIFQDYNLLDTLTV KENILLPLSITKLSKKEANRKFEEVAKELGIYELRDKYPNEISGGQKQRTSAGRAFIH DPSIIFADEPTGALDSKSASDLLNKLSQLNQKRNATIIMVTHDPVAASYCGRVIFIKD GQMYTQLNKGGQDRQTFFQDIMKTQGVLGGVQHEH*" /label="bceA CDS" gene complement(2608099..2608860) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /label="bceA gene" misc_feature complement(2608884..2608902) /Source="Nicolas_upshift_promotors" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2608903) /Source="Nicolas_upshifts" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2608962..2609966) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase controlling resistance to antibiotics affecting the envelope [YtsA]" /protein_id="NP_390917.1" /db_xref="EnsemblGenomes-Gn:BSU30390" /db_xref="EnsemblGenomes-Tr:CAB15017" /db_xref="GOA:O35044" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13919" /db_xref="UniProtKB/Swiss-Prot:O35044" /translation="MIKAFLIERRSWIAAFLFQQALMLFIAFVDPSISFGNVLYMVYL CILFFIIFLWFRYRKETAFYKSLKTWENNLDVTAINEPETPFEAMVERSIAGQTEHLK QTAARHRLALENEKDELMAWIHEVKTPLTAMHLIIDRMEEKALKSQLSYEWLRIHLLL DQQLHQKRISFIENDLSVEFIQLQPLIFKEIKDLQSWCIQKGIGFDIQLEAKEVLSDA KWLAFIIRQLLTNAVKYSEASEIEIKSFQKGEQTQLQVKDCGRGIDPKDVPRIFDKGF TSTTDHHDQASTGMGLYLAKKAAAPLLIHIDVESEFGAGTVFTLTFPIRNQFEHVISV *" /label="bceS CDS" gene complement(2608962..2609966) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /label="bceS gene" downshifts complement(2609001) /Source="Nicolas_upshifts" /id="D1566" /incds=0 /nref=25 /ntot=187 /MaxReadThrough="2.40611" /MaxDrop="4.6482" /score="29.3236847" /energy="-13.9" /TU="NA" /idTUdmin="U2357" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2609959..2610654) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator controlling resistance to antibiotics affecting the envelope [YtsB]" /protein_id="NP_390918.1" /db_xref="EnsemblGenomes-Gn:BSU30400" /db_xref="EnsemblGenomes-Tr:CAB15018" /db_xref="GOA:O34951" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12340" /db_xref="UniProtKB/Swiss-Prot:O34951" /translation="MFKLLLIEDDESLFHEIKDRLTGWSYDVYGIQDFSQVLQEFAAV NPDCVIIDVQLPKFDGFHWCRLIRSRSNVPILFLSSRDHPADMVMSMQLGADDFIQKP FHFDVLIAKIQAMFRRVHHYNTEPSTIKTWCGAAVDAEQNLVSNDKGSVELTKNEMFI LKQLIEQKNKIVSREELIRSLWNDERFVSDNTLTVNVNRLRKKLDALQLGAYIETKVG QGYIAKEEDKFYD*" /label="bceR CDS" gene complement(2609959..2610654) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /label="bceR gene" promotor_-10 complement(2610678..2610696) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2610690) /Source="Nicolas_upshifts" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2610712..2610715) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2610751..2612061) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="metabolite permease involved in resistance to cell wall inhibitors" /protein_id="NP_390919.1" /db_xref="EnsemblGenomes-Gn:BSU30410" /db_xref="EnsemblGenomes-Tr:CAB15019" /db_xref="GOA:O35005" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13916" /db_xref="UniProtKB/Swiss-Prot:O35005" /translation="MRFKDQVHFIRRNMKKNRLRVFMTILATTMACAFLVVLSSVGFG IQKTITDMTMSQQIVTKVSVMGKEGDKPIKKADLEKYDHVRSVVERTQVYEPNKATLG NRTNESSNLIFTNMNDELKANMELEKGRVAKSENEIVVGYDFAKRLLTKKESEEYNKK IEEAKGNPEDIKEPKGYTKDILNKTIELSVSKTDSKTGDVTKTKTYDFKIVGITKKPS QDWMEDSNIFISDQFKKDFSEFLDFKGGNVETNIGVFADKFENVEQLTNDLTDDGYYV TSVTTELEGANTFFMVFKIGLIFVGCIAVIISAIGIFNTMTMAVTERTQEIGIMKAIG ASPSIIRRMFLMESAYIGILGCVIGIIISYGVSYLVNLAVPMILAATSGGDAGDLNYT FSYIPASLVIIAVVICGGVAVISGMNPARKATKTNVLTALRREL*" /label="ytrF CDS" gene complement(2610751..2612061) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /label="ytrF gene" downshifts complement(2610773) /Source="Nicolas_upshifts" /id="D1567" /incds=0 /nref=9 /ntot=170 /MaxReadThrough="4.26891" /MaxDrop="3.83905" /score="28.2472037" /energy="-13.6" /TU="U2359" /idTUdmin="U2359" /TUdmin="-1755" /isTUend="FALSE" /label="downshifts" CDS complement(2612051..2612746) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22720735, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22720735, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390920.1" /db_xref="EnsemblGenomes-Gn:BSU30420" /db_xref="EnsemblGenomes-Tr:CAB15020" /db_xref="GOA:O34392" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13915" /db_xref="UniProtKB/Swiss-Prot:O34392" /translation="MIDVQHIDHSFTIGKKGRENEVPVLKDVSLSVAKGEIACIVGRS GSGKSTLLNLISGYISPTKGRIVINGTDVTGFNEKEWAQFRLDHFGFIFQSFQLIPGL TTYENVEMPLALKGIKPSERKQKVQDMLKRVGLENHAAHYPNELSGGQQQRVSIARAL ILNPSIILADEPTGSLDSETEHEVLELIQQLNRERGITFVIITHDDEVASIGHSKFQL HDGVLKGGITVEV*" /label="ytrE CDS" gene complement(2612051..2612746) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /label="ytrE gene" CDS complement(2612761..2613738) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390921.1" /db_xref="EnsemblGenomes-Gn:BSU30430" /db_xref="EnsemblGenomes-Tr:CAB15021" /db_xref="GOA:O34953" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13914" /db_xref="UniProtKB/Swiss-Prot:O34953" /translation="MPDSGLLYKEWRQNKVALVITILVFILGNPLSILNMYLIYQGCV TGKENWVGPCVFSVDYLNSSFISLFWIWGVVLAVSQLGIERSKSFFDFTLSLPYTRGQ IFHAKFLTGGMVIVVPQLIGYVLSVLLIMLLKPDQAVYFHNYSLGMIIVSMLAYSLVM AGGALTGNSFAQLLVSFTVAISPFLLISLPVINLEILFGGSIDFIHGPVPKWVQYFIP IIYVDSKWAENSPYYLVIPAIMTIIFYIIGYISFVKMSNERNGYFFLWKPLNRPVQII VIIIGIMGFGYFGFTASESFAGYLIGMGTGAVIGFLISYFAIYKKMKLL*" /label="ytrD CDS" gene complement(2612761..2613738) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /label="ytrD gene" CDS complement(2613768..2614754) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390922.1" /db_xref="EnsemblGenomes-Gn:BSU30440" /db_xref="EnsemblGenomes-Tr:CAB15022" /db_xref="GOA:O34898" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13913" /db_xref="UniProtKB/Swiss-Prot:O34898" /translation="MVDRGLLYREWKQNQVVILLSIAFLVLANPLSIVNTYLSYQGCL DRQDPQYCDFIVNYSISNLIDINWVPGVILAVCFLGMERSKGTMDFILSLPYNRSQIF QTKFWLGGFVIVLSQLIGFLLAWLLILVYNPEHVYFFEHSSIGVIVISFMAFSLVMAA GALTGNAFAQLLTAFSAAILPYLIIALPVGNLEVVFGANIWEIFPSPESYFSLASNLS NLVPISYVVNEWLINSKYLLLIPAVMSMLFYLIGFISFKKLPSERNGHFFLWNRLDRP VQILVMAFGILGFGLFGYYTGHSIIGYILGMIIGAVAGFFVSYFSIYKKTKV*" /label="ytrC CDS" gene complement(2613768..2614754) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /label="ytrC gene" promotor_-35 2614624..2614633 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2614640 /Source="Nicolas_upshifts" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2614646..2614661 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2614748..2615626) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390923.1" /db_xref="EnsemblGenomes-Gn:BSU30450" /db_xref="EnsemblGenomes-Tr:CAB15023" /db_xref="GOA:O34641" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13912" /db_xref="UniProtKB/Swiss-Prot:O34641" /translation="MIELRQLSKAIDGNQVLKDVSLTIEKGEIFGLLGRNGSGKTTML RLIQQIIFADSGTILFDGVEIKKHPKVKQNIIYMPVQNPFYDKYTYKQLVDILRRIYP KFDVTYANELMNRYEIPETKKYRELSTGLKKQLSLVLSFAARPALILLDEPTDGIDAV TRHDVLQLMVDEVAERDTSILITSHRLEDIERMCNRIGFLEDNSLTNVMDLDELKEEY IKIQMAFDTDVNLAIREQNIPMLDQAGVFYTVLIPKSDEEKKSFLRELKPKVWNELPV NLEEVFIAKFGGKRRW*" /label="ytrB CDS" gene complement(2614748..2615626) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /label="ytrB gene" CDS complement(2615619..2616011) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986249, 11756427, 17194626, 21856850, 28357385" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 11756427, 17194626, 21856850, 28357385; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family, cell wall antibiotics)" /protein_id="NP_390924.1" /db_xref="EnsemblGenomes-Gn:BSU30460" /db_xref="EnsemblGenomes-Tr:CAB15024" /db_xref="GOA:O34712" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13911" /db_xref="UniProtKB/Swiss-Prot:O34712" /translation="MIQIDPRSSTPIYEQIIQQMKELCLKGIMKPGDKLPSVRELATI IIANPNTVSKAYKELEREGIIETLRGRGTYISENAKTTLVEGKMTMIKEQLKQLIIDA HYAGVELEKLHEWIKEISADVKGGKKND*" /label="ytrA CDS" gene complement(2615619..2616011) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /label="ytrA gene" S_feature complement(2616012..2616256) /Source="Nicolas_S_feature" /locus_tag="new_3119240_3119484_c" /HighExp="Cold, Salt, SMMPr, MG 15, M9-tran, G180, M9-exp, M/G, MG 25, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.71885600000000005" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1162" CDS complement(2616045..2616182) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28357385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513999.1" /db_xref="EnsemblGenomes-Gn:BSU30466" /db_xref="EnsemblGenomes-Tr:CCQ48604" /db_xref="GOA:L8ECR1" /db_xref="UniProtKB/TrEMBL:L8ECR1" /translation="MKHKKRNKRNVPMLIAASVIACSFFLVLVMIGFEWQKSIIDHFY L*" /label="conserved protein of unknown function CDS" gene complement(2616045..2616182) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /label="gene" downshifts 2616180 /Source="Nicolas_upshifts" /id="D1568" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.62989" /MaxDrop="3.1332" /score="6.69010243" /energy="-14.4" /TU="NA" /idTUdmin="U2361" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2616251..2616270) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2616256) /Source="Nicolas_upshifts" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2616284..2616291) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2616337..2616609) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390925.1" /db_xref="EnsemblGenomes-Gn:BSU30470" /db_xref="EnsemblGenomes-Tr:CAB15025" /db_xref="InterPro:IPR019668" /db_xref="SubtiList:BG13937" /db_xref="UniProtKB/Swiss-Prot:O32073" /translation="MATRQSVDEHLQQCMQAYDYAEEQLKIASKQEHYNDQEYSDAQM QLEDAVNALNKLWLSSNDQQREQLYRMRLQLQSLQNNMILQHPLDV*" /label="ytzC CDS" gene complement(2616337..2616609) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /label="ytzC gene" downshifts complement(2616344) /Source="Nicolas_upshifts" /id="D1569" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.96566" /MaxDrop="8.4811" /score="36.3100501" /energy="-14.4" /TU="NA" /idTUdmin="U2360" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2616649..2616660) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2616653..2616661 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2616653) /Source="Nicolas_upshifts" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="upshifts" upshifts 2616664 /Source="Nicolas_upshifts" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2616675..2616681) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2616675..2616693 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2616704..2616709 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2616723..2616742 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2616730 /Source="Nicolas_upshifts" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="upshifts" CDS 2616771..2617739 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10413665; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_390926.1" /db_xref="EnsemblGenomes-Gn:BSU30480" /db_xref="EnsemblGenomes-Tr:CAB15026" /db_xref="GOA:O35008" /db_xref="InterPro:IPR005911" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032432" /db_xref="SubtiList:BG13908" /db_xref="UniProtKB/Swiss-Prot:O35008" /translation="MMQNNPFPYSNTEKRYHTLNYHLREHFGHKVFKVALDGGFDCPN RDGTVAHGGCTFCSAAGSGDFAGNRTDDLITQFHDIKNRMHEKWKDGKYIAYFQAFTN THAPVEVLREKFESVLALDDVVGISIATRPDCLPDDVVDYLAELNERTYLWVELGLQT VHERTALLINRAHDFNCYVEGVNKLRKHGIRVCSHIINGLPLEDRDMMMETAKAVADL DVQGIKIHLLHLLKGTPMVKQYEKGKLEFLSQDDYVQLVCDQLEIIPPEMIVHRITGD GPIELMIGPMWSVNKWEVLGAINKELENRGSYQGKFFQRLEEESAL*" /label="ytqA CDS" gene 2616771..2617739 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /label="ytqA gene" CDS 2617736..2618320 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24699744; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methylase" /protein_id="NP_390927.1" /db_xref="EnsemblGenomes-Gn:BSU30490" /db_xref="EnsemblGenomes-Tr:CAB15027" /db_xref="GOA:O34614" /db_xref="InterPro:IPR010719" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13909" /db_xref="UniProtKB/Swiss-Prot:O34614" /translation="MILKKILPYSKELLKMAAGEGDIVVDATMGNGHDTQFLAELVGE NGHVYAFDIQESAVANTKERLGDMYQARTTLFHKSHDKIAESLPPETHGKVAAAVFNL GYLPGGDKSITTNGSSTIKAIEQLLSIMKDEGLIVLVVYHGHPEGKAEKNDVLEFCRD LDQQTARVLTYGFINQQNDPPFIVAIEKKAQISK*" /label="ytqB CDS" gene 2617736..2618320 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /label="ytqB gene" downshifts 2618284 /Source="Nicolas_upshifts" /id="D1570" /incds=0 /nref=58 /ntot=249 /MaxReadThrough="2.35311" /MaxDrop="4.47418" /score="22.0352465" /energy="-11.9" /TU="NA" /idTUdmin="U2362" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2618310..>2618441) /gene="tbcS" /locus_tag="IIG_Bs13_pseudo_BSU_30500" /old_locus_tag="BSU_30500" /EC_number="4.2.3.130" /experiment="publication(s) with functional evidences, PMID:21627333, 24806199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21627333, 24806199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetraprenyl-beta-curcumene synthase" /protein_id="NP_390928.1" /db_xref="EnsemblGenomes-Gn:BSU30500" /db_xref="EnsemblGenomes-Tr:CAB15028" /db_xref="GOA:O34707" /db_xref="InterPro:IPR019712" /db_xref="SubtiList:BG13901" /db_xref="UniProtKB/Swiss-Prot:O34707" /modified_by="User" /translation="LAKKLIKASGKTSLFFYINGRAYRKFQKMSWMKNSKKKAQIIC* " /label="IIG_Bs13_pseudo_BSU_30500" gene complement(2618310..>2618441) /gene="tbcS" /locus_tag="IIG_Bs13_pseudo_BSU_30500" /old_locus_tag="BSU_30500" /modified_by="User" /label="IIG_Bs13_pseudo_BSU_30500" downshifts complement(2618351) /Source="Nicolas_upshifts" /id="D1571" /incds=0 /nref=35 /ntot=240 /MaxReadThrough="3.47268" /MaxDrop="4.45295" /score="16.7564664" /energy="-10.1" /TU="U2364" /idTUdmin="U2365" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" SCAR 2618444..2618445 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs13" S_feature complement(<2618445..2618460) /Source="Nicolas_S_feature" /locus_tag="new_3123442_3124021_c" /HighExp="dia15, H2O2, Diami, Salt, dia5, M0t90, Lbstat, Etha, Paraq, Lbtran" /AntisenseName="ytoA" /AntisenseCor="-0.44861767737485803" /AntisenseRegPval="-14" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1163" promotor_-10 complement(2618451..2618470) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2618460) /Source="Nicolas_upshifts" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2618462..2618596) /Source="Nicolas_S_feature" /locus_tag="new_3124023_3124157_c" /HighExp="LoTm, Cold, dia5, dia15, Diami, H2O2, S7, G135, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1164" promotor_-35 complement(2618482..2618489) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2618571..2618590) /Source="Nicolas_upshift_promotors" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2618596) /Source="Nicolas_upshifts" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2618689..2620080) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_390931.1" /db_xref="EnsemblGenomes-Gn:BSU30530" /db_xref="EnsemblGenomes-Tr:CAB15031" /db_xref="GOA:O34618" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG13891" /db_xref="UniProtKB/Swiss-Prot:O34618" /translation="MQKQKQELHRGLEERHISLMSLGAAIGVGLFLGSASAIQLAGPG ILVAYAASGLVMFFIMRALGEMAIQKPVAGSFSRYARDYLGPLAGYLTGWNYWFLWVV TCMAEITAVGIYMGFWFPDVPNWIWALSALVIMTGVNFLAVKAYGELEFWFALIKIVA ILSMIAVGLLMIIAGVGNGGIATGISNLWNNGGFFPHGLKGVLLSLQMVMFAYLGIEM IGVTAGEVKNPQKSLAKAIDTVFWRILIFYVGALFVIMSIYPWQEIGSQGSPFVLTFQ KVGIPSAAGIINFVVLTAALSSCNSGIFSTGRMLFNLAEQKEAPQAYGQLTKGGIPGK AVLASAGALLVGVLLNYVVPAKVFTWVTSIATFGAIWTWAIILLSQIKYRKSLKPEEK KQLKYKMPLFPFTSYVSLAFLAFVVILMAYSPDTRVAVIIGPIWFLILLAVYYGKGFH KKNAAAASERNIS*" /label="ytnA CDS" gene complement(2618689..2620080) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /label="ytnA gene" downshifts complement(2618697) /Source="Nicolas_upshifts" /id="D1572" /incds=0 /nref=133 /ntot=225 /MaxReadThrough="3.05784" /MaxDrop="5.43778" /score="3.82664462" /energy="-7.5" /TU="U2368" /idTUdmin="U2368" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(2620081..2620215) /Source="Nicolas_S_feature" /locus_tag="new_3125642_3125776_c" /HighExp="Oxctl, Paraq, Heat, Lbexp, G150, S0, dia0, H2O2, G180, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1165" CDS complement(2620216..2622114) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /EC_number="2.4.-.-" /EC_number="6.3.5.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 21949063, 28317238" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 21949063, 28317238; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-diaminopimelic acid amidotransferase (asparagine synthetase)" /protein_id="NP_390932.1" /db_xref="EnsemblGenomes-Gn:BSU30540" /db_xref="EnsemblGenomes-Tr:CAB15032" /db_xref="GOA:P54420" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11831" /db_xref="UniProtKB/Swiss-Prot:P54420" /translation="MCGFVGVFNKHPLAQTADQEELIKQMNQMIVHRGPDSDGYFHDE HVGFGFRRLSIIDVENGGQPLSYEDETYWIIFNGEIYNYIELREELEAKGYTFNTDSD TEVLLATYRHYKEEAASKLRGMFAFLIWNKNDHVLYGARDPFGIKPLYYTTINDQVYF ASERKSLMVAQNDIEIDKEALQQYMSFQFVPEPSTLDAHVKKVEPGSQFTIRPDGDIT FKTYFKANFKPVQTEEDKLVKEVRDAIYDSVNVHMRSDVPVGSFLSGGIDSSFIVSVA KEFHPSLKTFSVGFEQQGFSEVDVAKETAAALGIENISKVISPEEYMNELPKIVWHFD DPLADPAAIPLYFVAKEAKKHVTVALSGEGADELFGGYNIYREPLSLKPFERIPSGLK KMLLHVAAVMPEGMRGKSLLERGCTPLQDRYIGNAKIFEESVKKQLLKHYNPNLSYRD VTKTYFTESSSYSDINKMQYVDIHTWMRGDILLKADKMTMANSLELRVPFLDKVVFDV ASKIPDELKTKNGTTKYLLRKAAEGIVPEHVLNRKKLGFPVPIRHWLKNEMNEWVRNI IQESQTDAYIHKDYVLQLLEDHCADKADNSRKIWTVLIFMIWHSINIEKRYMPEELSH QPKEVIFV*" /label="asnB CDS" gene complement(2620216..2622114) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /label="asnB gene" promotor_-35 2621272..2621278 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2621293..2621304 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2621305 /Source="Nicolas_upshifts" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2622115..2622238) /Source="Nicolas_S_feature" /locus_tag="new_3127676_3127799_c" /HighExp="Paraq, G135, G180, G150, Oxctl, LBGexp, BMM, dia0, Heat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.632, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1166" CDS complement(2622264..2623466) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /EC_number="2.5.1.6" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16672621, 18634909" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16672621, 18634909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine synthetase" /protein_id="NP_390933.1" /db_xref="EnsemblGenomes-Gn:BSU30550" /db_xref="EnsemblGenomes-Tr:CAB15033" /db_xref="GOA:P54419" /db_xref="InterPro:IPR002133" /db_xref="InterPro:IPR022628" /db_xref="InterPro:IPR022629" /db_xref="InterPro:IPR022630" /db_xref="InterPro:IPR022631" /db_xref="InterPro:IPR022636" /db_xref="SubtiList:BG11840" /db_xref="UniProtKB/Swiss-Prot:P54419" /translation="MSKNRRLFTSESVTEGHPDKICDQISDSILDEILKKDPNARVAC ETSVTTGLVLVSGEITTSTYVDIPKTVRQTIKEIGYTRAKYGFDAETCAVLTSIDEQS ADIAMGVDQALEAREGTMSDEEIEAIGAGDQGLMFGYACNETKELMPLPISLAHKLAR RLSEVRKEDILPYLRPDGKTQVTVEYDENNKPVRIDAIVISTQHHPEITLEQIQRNIK EHVINPVVPEELIDEETKYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGA FSGKDATKVDRSAAYAARYVAKNIVAAELADSCEVQLAYAIGVAQPVSISINTFGSGK ASEEKLIEVVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRHDVDLPWERTDKAEQ LRKEALGE*" /label="metK CDS" gene complement(2622264..2623466) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /label="metK gene" downshifts complement(2622283) /Source="Nicolas_upshifts" /id="D1573" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="7.14538" /MaxDrop="3.78097" /score="-4.044113" /energy="-12.1" /TU="U2367,U2368" /idTUdmin="U2367" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2623509..2623520) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2623515) /Source="Nicolas_upshifts" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2623517..2623633) /Source="Nicolas_S_feature" /locus_tag="new_3129078_3129194_c" /HighExp="G180, Paraq, G150, Oxctl, G135, BMM, LBGexp, HPh, MG-0.2, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1167" promotor_-35 complement(2623534..2623540) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2623634..2623772) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswG RNA" gene complement(2623634..2623772) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /label="mswG gene" downshifts 2623732 /Source="Nicolas_upshifts" /id="D1574" /incds=0 /nref=3 /ntot=20 /MaxReadThrough="1.15866" /MaxDrop="4.97875" /score="11.8729615" /energy="-16.6" /TU="NA" /idTUdmin="U2369" /TUdmin="-1841" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2623781..2623800) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-10" upshifts complement(2623796) /Source="Nicolas_upshifts" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="upshifts" promotor_-35 complement(2623817..2623821) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-35" promotor_-35 2623893..2623900 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2623912 /Source="Nicolas_upshifts" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2623914..2623933 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2623969..2625552 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /EC_number="4.1.1.49" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400158, 4146915, 15491857, 15720552, 18586936, 20933603, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoenolpyruvate carboxykinase" /protein_id="NP_390934.2" /db_xref="EnsemblGenomes-Gn:BSU30560" /db_xref="EnsemblGenomes-Tr:CAB15034" /db_xref="GOA:P54418" /db_xref="InterPro:IPR001272" /db_xref="InterPro:IPR008210" /db_xref="InterPro:IPR013035" /db_xref="InterPro:IPR015994" /db_xref="SubtiList:BG11841" /db_xref="UniProtKB/Swiss-Prot:P54418" /translation="MNSVDLTADLQALLTCPNVRHNLSAAQLTEKVLSRNEGILTSTG AVRATTGAYTGRSPKDKFIVEEESTKNKIDWGPVNQPISEEAFERLYTKVVSYLKERD ELFVFEGFAGADEKYRLPITVVNEFAWHNLFARQLFIRPEGNDKKTVEQPFTILSAPH FKADPKTDGTHSETFIIVSFEKRTILIGGTEYAGEMKKSIFSIMNFLLPERDILSMHC SANVGEKGDVALFFGLSGTGKTTLSADADRKLIGDDEHGWSDTGVFNIEGGCYAKCIH LSEEKEPQIFNAIRFGSVLENVVVDEDTREANYDDSFYTENTRAAYPIHMINNIVTPS MAGHPSAIVFLTADAFGVLPPISKLTKEQAMYHFLSGYTSKLAGTERGVTSPETTFST CFGSPFLPLPAHVYAEMLGKKIDEHGADVFLVNTGWTGGGYGTGERMKLSYTRAMVKA AIEGKLEDAEMITDDIFGLHIPAHVPGVPDHILQPENTWTNKEEYKEKAVYLANEFKE NFKKFAHTDAIAQAGGPLV*" /label="pckA CDS" gene 2623969..2625552 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /label="pckA gene" downshifts 2625541 /Source="Nicolas_upshifts" /id="D1575" /incds=0 /nref=106 /ntot=269 /MaxReadThrough="2.55056" /MaxDrop="8.3695" /score="11.8729615" /energy="-16.6" /TU="U2369" /idTUdmin="U2369" /TUdmin="-32" /isTUend="FALSE" /label="downshifts" CDS complement(2625591..2625833) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390935.1" /db_xref="EnsemblGenomes-Gn:BSU30570" /db_xref="EnsemblGenomes-Tr:CAB15035" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019699" /db_xref="PDB:2NWA" /db_xref="SubtiList:BG13882" /db_xref="UniProtKB/Swiss-Prot:O34365" /translation="MGMPVEFNTLIVTKGKEVRIDENIFTLEKDGYRVYPMEIPMDVR KTKFGEKSGTAEVQKLQWEEGRTIITYKLTSLHSVN*" /label="ytmB CDS" gene complement(2625591..2625833) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /label="ytmB gene" downshifts complement(2625605) /Source="Nicolas_upshifts" /id="D1576" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="1.2088" /MaxDrop="5.1365" /score="38.3436505" /energy="-16.6" /TU="NA" /idTUdmin="U2371" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2625885..2626658) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27899916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative esterase" /protein_id="NP_390936.1" /db_xref="EnsemblGenomes-Gn:BSU30580" /db_xref="EnsemblGenomes-Tr:CAB15036" /db_xref="GOA:O34493" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13881" /db_xref="UniProtKB/Swiss-Prot:O34493" /translation="MIVEKRRFPSPSQHVRLYTICYLSNGLRVKGLLAEPAEPGQYDG FLYLRGGIKSVGMVRPGRIIQFASQGFVVFAPFYRGNQGGEGNEDFAGEDREDAFSAF RLLQQHPNVKKDRIHIFGFSRGGIMGMLTAIEMGGQAASFVSWGGVSDMILTYEERQD LRRMMKRVIGGTPKKVPEEYQWRTPFDQVNKIQAPVLLIHGEKDQNVSIQHSYLLEEK LKQLHKPVETWYYSTFTHYFPPKENRRIVRQLTQWMKNR*" /label="ytmA CDS" gene complement(2625885..2626658) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /label="ytmA gene" S_feature complement(2626659..2626749) /Source="Nicolas_S_feature" /locus_tag="new_3132220_3132310_c" /HighExp="S8, dia15, Diami, Etha, S7, dia5, H2O2, G180, Heat, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1168" promotor_-35 2626725..2626734 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2626738..2626757) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2626746 /Source="Nicolas_upshifts" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2626747..2626766 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2626751) /Source="Nicolas_upshifts" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2626772..2626779) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2626809..2627813 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component" /protein_id="NP_390937.2" /db_xref="EnsemblGenomes-Gn:BSU30595" /db_xref="EnsemblGenomes-Tr:CAB15037" /db_xref="GOA:C0SP84" /db_xref="SubtiList:BG13873" /db_xref="UniProtKB/Swiss-Prot:C0SP84" /translation="MNRWLRLGFACVGSIFLMFALAACKQEETLTKVKVAEVTHSIFY APLYVAESKGFFKEEGLDVDVNTTWGGDKTMTSLLSNGSDIALVGSETSIYVEAQGAK DPVINFAQLTQTDGTFLVAREDVEHFDWDQLKGKTFLGQRKGGMPQMVGEYVLNKHKI DPHKDIDLIQNIDFANIANAFASGTGEYVQLFEPQASLFEKKGIGHIVASFGEESGEV PYTTFMAKQSYLKKNEDTAVKFTKAIYKAQQWVENHSAKDITDAIKDEFDDTDPDVIE TSIERYKKQHSYSPDPLLNEKEWELLQTIMDKSGELPKHIPYNQLVNKEIAEKVTSEK *" /label="ytlA CDS" gene 2626809..2627813 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /label="ytlA gene" CDS 2627826..2628608 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component, ATP-binding" /protein_id="NP_390939.1" /db_xref="EnsemblGenomes-Gn:BSU30610" /db_xref="EnsemblGenomes-Tr:CAB15039" /db_xref="GOA:O34314" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13875" /db_xref="UniProtKB/Swiss-Prot:O34314" /translation="MSFLHVDHVTHTYFSIKEKTTAVRDIHFDAEKGDFISFLGPSGC GKTTLLSIIAGLIEPSEGRVLIEGREPNQKEHNIGYMLQQDYLFPWKSIEENVLLGLK IADTLTEESKAAALGLLPEFGLIDVEKKYPKELSGGMRQRAALARTLAPNPSLLLLDE PFSALDFQTKLSLENLVFRTLKEYQKTAVLVTHDIGEAIAMSDTIFLFSNQPGTIHQI FTIPKELAAMLPFDARQEPSFQTLFQTIWKELNSLEKQQRNH*" /label="ytlC CDS" gene 2627826..2628608 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /label="ytlC gene" S_feature complement(2627830..2629378) /Source="Nicolas_S_feature" /locus_tag="new_3133391_3134939_c" /HighExp="Cold, S8, G180, H2O2, G135, Paraq, G150, S7, Oxctl, LPh" /AntisenseName="ytlC" /AntisenseCor="0.110169300738282" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1169" CDS 2628583..2629395 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease of ABC anion transporter" /protein_id="NP_390940.1" /db_xref="EnsemblGenomes-Gn:BSU30620" /db_xref="EnsemblGenomes-Tr:CAB15040" /db_xref="GOA:O34649" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13876" /db_xref="UniProtKB/Swiss-Prot:O34649" /translation="MRNSKETIDLLHEQYQFKQKKEKWKVHSFQLAIFILFFSGWEIS SRQGWIDPLIFSSPSAVWRLLLEKLGDGSLLSHIGVTLFETVLGFLLGTFMGTCLAAL LWWSNRLARILDPYLVILNAMPKVALGPILIVALGPSFISIIAMGAIISVIITTIVVY TAFQEVDENYTKVMKTFGAKKWVIFKEVILPASSPAIISTLKVNVGLSWVGVIVGEFL VSKVGLGYMIIYGFQVFNFTLVFLSLLIIAIFATLMYQGVELLEKKWTKGRT*" /label="ytlD CDS" gene 2628583..2629395 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /label="ytlD gene" downshifts 2629380 /Source="Nicolas_upshifts" /id="D1577" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="3.58734" /MaxDrop="4.596" /score="38.1379668" /energy="-12.6" /TU="U2370" /idTUdmin="U2370" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(2629422..2629898) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /EC_number="3.6.1.15" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576788, 16513759, 21925382, 23610407, 23610425, 27936487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576788, 16513759, 21925382, 23610407, 23610425, 27936487; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nucleoside and RNA triphosphate phosphohydrolase" /protein_id="NP_390941.1" /db_xref="EnsemblGenomes-Gn:BSU30630" /db_xref="EnsemblGenomes-Tr:CAB15041" /db_xref="GOA:O35013" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR014078" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="PDB:4JZS" /db_xref="PDB:4JZT" /db_xref="PDB:4JZU" /db_xref="PDB:4JZV" /db_xref="SubtiList:BG13869" /db_xref="UniProtKB/Swiss-Prot:O35013" /translation="MYEFKDYYQNTVQLSFDDQPFSDSPKHVWVICRFGGKWLLTEHE DRGYEFPGGKVEPMECAEEAALREVKEETGARVKSLKYLGQYKVLGKEKVIVKNIYFA DIEKLEKQADYFETKGPVLFHELPENLSRNKKFSFIMKDSVLPISLKKLKESGWIE*" /label="rppG CDS" gene complement(2629422..2629898) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /label="rppG gene" downshifts complement(2629423) /Source="Nicolas_upshifts" /id="D1578" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.52721" /MaxDrop="6.99686" /score="36.2618206" /energy="-12.6" /TU="U2372" /idTUdmin="U2373" /TUdmin=11 /isTUend="TRUE" /label="downshifts" misc_feature complement(2629928..2629947) /Source="Nicolas_upshift_promotors" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2629941) /Source="Nicolas_upshifts" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2629943..2630077) /Source="Nicolas_S_feature" /locus_tag="new_3135504_3135638_c" /HighExp="BT, B36, S8, S5, S7, Etha, S6, S4, B60, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK, SigB" /TUshortPSig="0.909, 1, 0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1170" upshifts complement(2630077) /Source="Nicolas_upshifts" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2630079..2630090) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2630105..2630111) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2630107..2630511) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative autolytic amidase" /protein_id="NP_390942.1" /db_xref="EnsemblGenomes-Gn:BSU30640" /db_xref="EnsemblGenomes-Tr:CAB15042" /db_xref="GOA:O34883" /db_xref="InterPro:IPR006480" /db_xref="SubtiList:BG13868" /db_xref="UniProtKB/Swiss-Prot:O34883" /translation="MDRDFGIFSFLAVSVSAAGFFFGGFQYSFLILLSLMAIEFISTT LKETIIHKLSFKKVFARLVKKLVTLALISVCHFFDQLLNTQGSIRDLAIMFYILYESV QIVVTASSLGIPVPQMLVDLLETLKNKFKRKP*" /label="ytkC CDS" gene complement(2630107..2630511) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /label="ytkC gene" promotor_-10 complement(2630539..2630558) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2630556) /Source="Nicolas_upshifts" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2630558..2630644) /Source="Nicolas_S_feature" /locus_tag="new_3136119_3136205_c" /HighExp="Etha, B36, S8, B60, S7, LoTm, Salt, Sw, Gly, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1171" promotor_-35 complement(2630571..2630580) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2630677..2631114) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12767829, 16091047, 16861227, 16935006; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-protecting protein, mini-ferritin" /protein_id="NP_390943.1" /db_xref="EnsemblGenomes-Gn:BSU30650" /db_xref="EnsemblGenomes-Tr:CAB15043" /db_xref="GOA:P80879" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="SubtiList:BG12584" /db_xref="UniProtKB/Swiss-Prot:P80879" /translation="MSEQLIQAVNKQVANWTVMYVKLHNYHWYVKGKDFFTLHEKFEE LYNETATYIDDLAERLLALNGKPIATMKESLETASVKEAAGNETAEQMVQSVYDDFTV IAEELKNGMDLADEVGDETTGDMLLAIHQNIEKHNWMLKAYLG*" /label="dps CDS" gene complement(2630677..2631114) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /label="dps gene" downshifts complement(2630689) /Source="Nicolas_upshifts" /id="D1579" /incds=0 /nref=188 /ntot=382 /MaxReadThrough="3.87056" /MaxDrop="7.83664" /score="36.0931083" /energy="-19.2" /TU="U2375" /idTUdmin="U2377" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2631131..2631149) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2631149) /Source="Nicolas_upshifts" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2631151..2631376) /Source="Nicolas_S_feature" /locus_tag="new_3136712_3136937_c" /HighExp="M0t90, Lbstat, M40t90, ferm, S2, nit, M40t45, S0, Lbtran, BT" /AntisenseName="ytzI" /AntisenseCor="-0.30531150128448598" /AntisenseRegPval="-6.5" /CDS_PredictionProba="0.38276900000000003" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1172" promotor_-35 complement(2631164..2631170) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2631206..2631225 /Source="Nicolas_upshift_promotors" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2631207..2631383 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097774.1" /db_xref="EnsemblGenomes-Gn:BSU30659" /db_xref="EnsemblGenomes-Tr:CAX52680" /db_xref="GOA:C0H3Q1" /db_xref="InterPro:IPR022248" /db_xref="UniProtKB/Swiss-Prot:C0H3Q1" /translation="MLQLLKNGRWNVMTLLITISILIVLAVLLVTIWTTVKAYNVKHT IDPPQENHSDSHNQ*" /label="ytzI CDS" gene 2631207..2631383 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /label="ytzI gene" upshifts 2631208 /Source="Nicolas_upshifts" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2631377..2631814) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390944.1" /db_xref="EnsemblGenomes-Gn:BSU30660" /db_xref="EnsemblGenomes-Tr:CAB15044" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR032693" /db_xref="SubtiList:BG11027" /db_xref="UniProtKB/Swiss-Prot:P40768" /translation="MKKMLVVLLFSALLLNGCGSGESKANTAETPEVLDVKLTGPEKV NPGESAAYEAAVSYGDEAVTDADEVEFEVWKEGEKDASQMFKVKQEKGVYRLETTFKE DGVYTVQSHVTAKKQHSMPTLKVQVGDADAASNQSEEEHSHHH*" /label="ytkA CDS" gene complement(2631377..2631814) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /label="ytkA gene" downshifts 2631403 /Source="Nicolas_upshifts" /id="D1580" /incds=0 /nref=37 /ntot=155 /MaxReadThrough="2.0116" /MaxDrop="3.95427" /score="13.1411485" /energy="-20.5" /TU="NA" /idTUdmin="U2376" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2631833..2631852) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-10" upshifts complement(2631854) /Source="Nicolas_upshifts" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 complement(2631863..2631871) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-35" CDS complement(2631934..2632407) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /EC_number="4.4.1.21" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-ribosylhomocysteine lyase" /protein_id="NP_390945.1" /db_xref="EnsemblGenomes-Gn:BSU30670" /db_xref="EnsemblGenomes-Tr:CAB15045" /db_xref="GOA:O34667" /db_xref="InterPro:IPR003815" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR037005" /db_xref="PDB:1IE0" /db_xref="PDB:1J98" /db_xref="PDB:1JQW" /db_xref="PDB:1JVI" /db_xref="PDB:1YCL" /db_xref="PDB:2FQO" /db_xref="PDB:2FQT" /db_xref="SubtiList:BG13866" /db_xref="UniProtKB/Swiss-Prot:O34667" /translation="MPSVESFELDHNAVVAPYVRHCGVHKVGTDGVVNKFDIRFCQPN KQAMKPDTIHTLEHLLAFTIRSHAEKYDHFDIIDISPMGCQTGYYLVVSGEPTSAEIV DLLEDTMKEAVEITEIPAANEKQCGQAKLHDLEGAKRLMRFWLSQDKEELLKVFG*" /label="luxS CDS" gene complement(2631934..2632407) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /label="luxS gene" downshifts complement(2631943) /Source="Nicolas_upshifts" /id="D1581" /incds=0 /nref=72 /ntot=201 /MaxReadThrough="4.53626" /MaxDrop="4.63695" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-793" /isTUend="FALSE" /label="downshifts" downshifts complement(2632030) /Source="Nicolas_upshifts" /id="D1582" /incds=1 /nref=1 /ntot=96 /MaxReadThrough="5.57623" /MaxDrop="2.4806" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" S_feature complement(2632408..2632759) /Source="Nicolas_S_feature" /locus_tag="new_3137969_3138320_c" /HighExp="Etha, B36, B60, BMM, S2, Heat, S1, LoTm, Lbtran, S5" /AntisenseName="ytjA" /AntisenseCor="-0.45038987072908898" /AntisenseRegPval="-14.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1173" promotor_-35 2632479..2632486 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2632499..2632518 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2632504 /Source="Nicolas_upshifts" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2632536..2632763 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19306042, 21803992; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein insertion efficiency factor" /protein_id="NP_390946.1" /db_xref="EnsemblGenomes-Gn:BSU30680" /db_xref="EnsemblGenomes-Tr:CAB15046" /db_xref="GOA:O34601" /db_xref="InterPro:IPR002696" /db_xref="SubtiList:BG13865" /db_xref="UniProtKB/Swiss-Prot:O34601" /translation="MKTLFIALIRGYQKFISPLTPPTCRFYPTCSQYGIEAIKTHGAL KGGWLTIKRILKCHPFHPGGVDPVPEKKQKH*" /label="ytjA CDS" gene 2632536..2632763 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /label="ytjA gene" CDS complement(2632760..2633323) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /EC_number="4.2.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12193617, 21266987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carbonic anhydrase" /protein_id="NP_390947.1" /db_xref="EnsemblGenomes-Gn:BSU30690" /db_xref="EnsemblGenomes-Tr:CAB15047" /db_xref="GOA:O34872" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG13863" /db_xref="UniProtKB/Swiss-Prot:O34872" /translation="MSLLNDILEFNKTFTEQREYEKYQTSKFPDKKMAILSCMDTRLV ELLPHAMNLRNGDVKIIKSAGALVTHPFGSIMRSILVAVYELNADEVCVIGHHDCGMS KISSKSMLEKIKARGIPEERIETIKYSGVDFDQWFKSFDSVEASVKDSVDVIKHHPLF PENVPVHGLVIDPKTGKLDLIVNGYNN*" /label="ytiB CDS" gene complement(2632760..2633323) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /label="ytiB gene" misc_feature complement(2633348..2633367) /Source="Nicolas_upshift_promotors" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2633363) /Source="Nicolas_upshifts" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2633417..2633665) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15049826, 16014871, 16547061, 19648245, 20208344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15049826, 16014871, 16547061, 19648245, 20208344; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_390948.1" /db_xref="EnsemblGenomes-Gn:BSU30700" /db_xref="EnsemblGenomes-Tr:CAB15048" /db_xref="GOA:O34967" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027493" /db_xref="InterPro:IPR034704" /db_xref="SubtiList:BG13862" /db_xref="UniProtKB/Swiss-Prot:O34967" /translation="MKEGIHPKNHKVIFQDVNSGYRFLSTSTKTSNETAEWEDGNTYP VIKVEVSSDTHPFYTGRQKFNEKGGRVEQFKKRYNMGK*" /label="rpmEB CDS" gene complement(2633417..2633665) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /label="rpmEB gene" downshifts complement(2633438) /Source="Nicolas_upshifts" /id="D1583" /incds=0 /nref=96 /ntot=217 /MaxReadThrough="7.96356" /MaxDrop="4.50701" /score="15.8096104" /energy="-7.5" /TU="U2380" /idTUdmin="U2380" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2633693..2633712) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-10" promotor_-35 complement(2633726..2633733) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-35" upshifts complement(2633730) /Source="Nicolas_upshifts" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 2633792..2633798 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-35" promotor_-10 2633812..2633823 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-10" upshifts 2633824 /Source="Nicolas_upshifts" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="upshifts" CDS 2633870..2635201 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9852001, 10551842, 15849754, 16850406, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit I" /protein_id="NP_390949.2" /db_xref="EnsemblGenomes-Gn:BSU30710" /db_xref="EnsemblGenomes-Tr:CAB15049" /db_xref="GOA:C0SP90" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG13857" /db_xref="UniProtKB/Swiss-Prot:C0SP90" /translation="MDDLVLARSLFGTTMGFHIIFATLGVGLPLMILVAELIYQKTKD DHYAIMAKRWTKAQAVLLGVAIPTGTIAGTQLALLWPGFMEVIGRVMSLPFQIEIYAF FVEALFMSIYVYAADRLSPAMRIVAVFFVLVGAAASAVLITNVHAFEGTPAGFKILNG KITDVDPWAAFFNPSFFITAGHVVLSAFMTGAFIVASVAAYKMIRTRKKERVYRFHRK ALLLALTIGGIFSLLTALNGHESAQMLYEYQPEKLAGAEGLFETRSHAPLAIGGFTDP NEEKVKWAIEIPWALSFLAANRFDTVVKGLNAFPRDEWPPLFIHTLFNAMVGVGMLLI LYSIIGVVWRKVLKKDRFPTWLLIIFMTAGPFSLIGIEFGWIFACTGRQPWVIYHLLK TSDVVTTTGSIGVLFLFFTFVYAVLGAAVVYVLLYYFRKHPVDEDLNTAES*" /label="ythA CDS" gene 2633870..2635201 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /label="ythA gene" CDS 2635245..2636285 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11073895, 15576792, 15849754, 16850406, 10551842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit II" /protein_id="NP_390950.1" /db_xref="EnsemblGenomes-Gn:BSU30720" /db_xref="EnsemblGenomes-Tr:CAB15050" /db_xref="GOA:O34505" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG13858" /db_xref="UniProtKB/Swiss-Prot:O34505" /translation="MEISTDALIAISIIWGFVFIYAVMATMDFGAGFWSMIYLNKEHM KATDIANRFLSPTWEVTNVFIVAIVVALFSFFPGATFVLGTVLLIPGSMILLLLAIRS GFLVFSNTAKERKTLRYISGISGFIIPAILILVLPVTHGGFIEKTDGIYNLNMSKIFS SPNAYSFIGFAILSTLFLSSLLLADFSNVAEEQDAYRAYRKSALITGPISLLFAVCIM VTMRNEANWLYSGMMNDFSWIIASFITFVIAGIALFLPNKSFGQNIGKPRLALVAIGI QYFLASYAYGRAHLPYMIYPDVTVMSGFTEPATFRALFATYIVAFIILFPGFFFFWKM FMRDKRYIRQEE*" /label="ythB CDS" gene 2635245..2636285 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /label="ythB gene" promotor_-35 2636279..2636285 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2636300..2636311 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2636310 /Source="Nicolas_upshifts" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="upshifts" CDS 2636339..2636497 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097775.1" /db_xref="EnsemblGenomes-Gn:BSU30739" /db_xref="EnsemblGenomes-Tr:CAX52681" /db_xref="InterPro:IPR011437" /db_xref="UniProtKB/Swiss-Prot:C0H3Q2" /translation="MEQKILCEVNNCSYWGKGNKCTADAIYVVSHTGETAENSRETDC KTFKPHDL*" /label="ytzL CDS" gene 2636339..2636497 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /label="ytzL gene" downshifts 2636486 /Source="Nicolas_upshifts" /id="D1584" /incds=0 /nref=55 /ntot=88 /MaxReadThrough="1.7679" /MaxDrop="7.01398" /score="-5.86934022" /energy="-7" /TU="NA" /idTUdmin="U2382" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2636516..2637403) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390952.1" /db_xref="EnsemblGenomes-Gn:BSU30740" /db_xref="EnsemblGenomes-Tr:CAB15052" /db_xref="GOA:O34500" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG13854" /db_xref="UniProtKB/Swiss-Prot:O34500" /translation="MSFEAWIIATGVLVGVSCGLIGTFLVLRSMAMLADAISHTVLLG IVGAFLVTGSLDGIYMFIGAAATGLLTAFLVQLLHSKGVQSDAAIGVVFTSLFAIGVI LLSVYGANVHLDIEHSLMGEIAFVPWNTVTVFGVDIGPKAFWMLASVLVLNVVLISVC YKEFKIASFDPQMALALGIPVLLIHYVQMGMLSLTTVASFDSVGAVLVVAMLIVPPAA AHLLTDRLLYMLILSALIGGLSAVMGYFFATWLNVSISGAMAAMTGVCYASAFLFSPA NGVITKKLRTLNMQKERAG*" /label="mntD CDS" gene complement(2636516..2637403) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /label="mntD gene" downshifts complement(2636539) /Source="Nicolas_upshifts" /id="D1585" /incds=0 /nref=121 /ntot=218 /MaxReadThrough="3.39755" /MaxDrop="6.80546" /score="-8.37820006" /energy="-7" /TU="U2385" /idTUdmin="U2385" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" CDS complement(2637393..2638700) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390953.1" /db_xref="EnsemblGenomes-Gn:BSU30750" /db_xref="EnsemblGenomes-Tr:CAB15053" /db_xref="GOA:O35024" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13853" /db_xref="UniProtKB/Swiss-Prot:O35024" /translation="MFESLWLQLQHPNTQWVLAGTLLLGTASGVLGSFVLLRKQSLIG DAMAHSALPGVCLAFLFTGQKSLPFFLLGAALAGLLGTFCIQLIPRLSKTKEDSAIGI VLSVFFGVGIILLTYIQQQGAGSQSGLDSFLFGQAASLVRQDIILIAGISAVLLLLCI VFFKEFTLITFDLAFAKGLGIPVRFLNGLLACLIVCAVVIGLQTVGVILMAAMLITPA ITARYWTERLTGMIIIAGITGGVSGVAGTLLSTTMKGMATGPLMILSATLLFLFSMIC APKRGLAAKAIRLMRLRRRTSREQVLLAIYEQYEKNNLCVTVESVRKKRRLSPSLCLK ALNDLEQERCIERIENGIWQITSKGIEKGYHTALKQRMYEVYLMHEMELANIESDQDY FDPDRLPRETRERLYSLLKLYGRMPERRKASHDAEKGQIANEF*" /label="mntC CDS" gene complement(2637393..2638700) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /label="mntC gene" CDS complement(2638706..2639458) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type t: transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (ATP-binding protein)" /protein_id="NP_390954.1" /db_xref="EnsemblGenomes-Gn:BSU30760" /db_xref="EnsemblGenomes-Tr:CAB15054" /db_xref="GOA:O34338" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13852" /db_xref="UniProtKB/Swiss-Prot:O34338" /translation="MFPVELDNVTVAYHKKPVLQDISLQVPEGKLIGIIGPNGAGKST LIKTILGLVPRASGDISIYGKDYKDQRTRIGYVPQRGSVDWDFPTSPLDVVLMGRYGR IGLLKRPKKADVEMAKAALTKVGMHDYAKRQISQLSGGQQQRVFLARALCQNADIYFM DEPFAGVDAATERAIMTLLAELKEKGKTVLVVHHDLQTAEDYFDWILLLHLRKIAFGP TENVFTIENLQKTYGGRLTFLKDKVLAEGHKE*" /label="mntB CDS" gene complement(2638706..2639458) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /label="mntB gene" CDS complement(2639477..2640397) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (manganese binding lipoprotein)" /protein_id="NP_390955.1" /db_xref="EnsemblGenomes-Gn:BSU30770" /db_xref="EnsemblGenomes-Tr:CAB15055" /db_xref="GOA:O34385" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="SubtiList:BG13851" /db_xref="UniProtKB/Swiss-Prot:O34385" /translation="MRQGLMAAVLFATFALTGCGTDSAGKSADQQLQVTATTSQIADA AENIGGKHVKVTSLMGPGVDPHLYKASQGDTKKLMSADVVLYSGLHLEGKMEDVLQKI GEQKQSAAVAEAIPKNKLIPAGEGKTFDPHVWFSIPLWIYAVDEIEAQFSKAMPQHAD AFRKNAKEYKEDLQYLDKWSRKEIAHIPEKSRVLVTAHDAFAYFGNEYGFKVKGLQGL STDSDYGLRDVQELVDLLTEKQIKAVFVESSVSEKSINAVVEGAKEKGHTVTIGGQLY SDAMGEKGTKEGTYEGMFRHNINTITKALK*" /label="mntA CDS" gene complement(2639477..2640397) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /label="mntA gene" promotor_-10 complement(2640433..2640444) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2640434) /Source="Nicolas_upshifts" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2640436..2640527) /Source="Nicolas_S_feature" /locus_tag="new_3145997_3146088_c" /HighExp="T-0.40H, Sw, T-1.40H, BC, C90, C30, BI, T0.0H, T-3.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.985, 0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1174" promotor_-35 complement(2640458..2640464) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2640512 /Source="Nicolas_upshifts" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2640513..2640532) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2640515..2640527 /Source="Nicolas_upshift_promotors" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2640527) /Source="Nicolas_upshifts" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2640529..2640610) /Source="Nicolas_S_feature" /locus_tag="new_3146090_3146171_c" /HighExp="T1.30H, T1.0H, C30, T0.30H, T2.0H, T2.30H, T-0.40H, T-1.40H, T-2.40H, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1175" promotor_-35 complement(2640547..2640554) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2640610) /Source="Nicolas_upshifts" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="upshifts" promotor_-10 complement(2640619..2640638) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-10" promotor_-35 complement(2640652..2640659) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-35" CDS complement(2640677..2641792) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /EC_number="4.2.1.113" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoate-CoA synthase" /protein_id="NP_390956.1" /db_xref="EnsemblGenomes-Gn:BSU30780" /db_xref="EnsemblGenomes-Tr:CAB15056" /db_xref="GOA:O34514" /db_xref="InterPro:IPR010197" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG13847" /db_xref="UniProtKB/Swiss-Prot:O34514" /translation="MIEIEKITLYHLSMNLKKPFKNSIETLQERKFLIVEAIDTSGVT GWGEVSAFSSPWYTEETIGTCLHMLKDFFIPNVVGREFNHPSEVPDSLARYKGNRMAK AGLESAVWDIYAKKKGVSLAEALGGTRDKVPAGVVVGLAPLDDMLKEIESYQKEGYQR IKIKIQPGQDVELVKAIRSRFPTIPLMADANSSYELKDISRLKELDDYHLMMIEQPLQ ADDIVDHRHLQKHLKTAICLDESICSVDDARRAIELGSCKIINIKPSRVGGLTEALKI HDLCKEHHMQVWCGGMLETGISRAQNVALASLPQFTIPGDISSSSRYWDEDIVTPDIR IDNGFISVSKQPGLGVEVNQDIMRKYVTKMDVFTQHG*" /label="menC CDS" gene complement(2640677..2641792) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /label="menC gene" downshifts complement(2640720) /Source="Nicolas_upshifts" /id="D1586" /incds=0 /nref=12 /ntot=179 /MaxReadThrough="3.8638" /MaxDrop="2.96378" /score="29.7201414" /energy="-11.1" /TU="U2387,U2388" /idTUdmin="U2388" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2641789..2643249) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /EC_number="6.2.1.26" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299, 28559280" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299, 28559280; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoic acid-CoA ligase" /protein_id="NP_390957.1" /db_xref="EnsemblGenomes-Gn:BSU30790" /db_xref="EnsemblGenomes-Tr:CAB15057" /db_xref="GOA:P23971" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010192" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:5BUQ" /db_xref="PDB:5BUR" /db_xref="PDB:5BUS" /db_xref="PDB:5GTD" /db_xref="PDB:5X8F" /db_xref="PDB:5X8G" /db_xref="SubtiList:BG10687" /db_xref="UniProtKB/Swiss-Prot:P23971" /translation="MLTEQPNWLMQRAQLTPERIALIYEDQTVTFAELFAASKRMAEQ LAAHSVRKGDTAAILLQNRAEMVYAVHACFLLGVKAVLLNTKLSTHERLFQLEDSGSG FLLTDSSFEKKEYEHIVQTIDVDELMKEAAEEIEIEAYMQMDATATLMYTSGTTGKPK GVQQTFGNHYFSAVSSALNLGITEQDRWLIALPLFHISGLSALFKSVIYGMTVVLHQR FSVSDVLHSINRHEVTMISAVQTMLASLLEETNRCPESIRCILLGGGPAPLPLLEECR EKGFPVFQSYGMTETCSQIVTLSPEFSMEKLGSAGKPLFSCEIKIERDGQVCEPYEHG EIMVKGPNVMKSYFNRESANEASFQNGWLKTGDLGYLDNEGFLYVLDRRSDLIISGGE NIYPAEVESVLLSHPAVAEAGVSGAEDKKWGKVPHAYLVLHKPVSAGELTDYCKERLA KYKIPAKFFVLDRLPRNASNKLLRNQLKDARKGELL*" /label="menE CDS" gene complement(2641789..2643249) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /label="menE gene" promotor_-10 complement(2642692..2642710) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2642696) /Source="Nicolas_upshifts" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2642725..2642731) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2643338) /Source="Nicolas_upshifts" /id="D1587" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="4.92536" /MaxDrop="2.4145" /score="1.01127104" /energy="-10.8" /TU="U2388" /idTUdmin="U2389" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS complement(2643340..2644155) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /EC_number="4.1.3.36" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxynapthoic acid synthetase" /protein_id="NP_390958.1" /db_xref="EnsemblGenomes-Gn:BSU30800" /db_xref="EnsemblGenomes-Tr:CAB15058" /db_xref="GOA:P23966" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR010198" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG10686" /db_xref="UniProtKB/Swiss-Prot:P23966" /translation="MAEWKTKRTYDEILYETYNGIAKITINRPEVHNAFTPKTVAEMI DAFADARDDQNVGVIVLAGAGDKAFCSGGDQKVRGHGGYVGDDQIPRLNVLDLQRLIR VIPKPVVAMVSGYAIGGGHVLHIVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARI VGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLEQLEEETIKWCEEMLEKSPTALRFL KAAFNADTDGLAGIQQFAGDATLLYYTTDEAKEGRDSFKEKRKPDFGQFPRFP*" /label="menB CDS" gene complement(2643340..2644155) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /label="menB gene" CDS complement(2644190..2645014) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /EC_number="4.2.99.20" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12454479, 23637813; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase" /protein_id="NP_390959.1" /db_xref="EnsemblGenomes-Gn:BSU30810" /db_xref="EnsemblGenomes-Tr:CAB15059" /db_xref="GOA:P23974" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR022485" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10685" /db_xref="UniProtKB/Swiss-Prot:P23974" /translation="MGTVNITVSDGVRYAVADEGPNASEAVVCLHGFTGSKQSWTFLD EMLPDSRLIKIDCLGHGETDAPLNGKRYSTTRQVSDLAEIFDQLKLHKVKLIGYSMGG RLAYSFAMTYPERVSALVLESTTPGLKTLGERRERIMRDRKLADFILRDGLEAFVAYW ENIPLFSSQQRLAEDIRYRIRSGRLRNNKIGLANSLTGMGTGSQPSLWSRVEEIDVPV LLICGEWDEKFCAINQEVHKMLPSSRIEIVPKAGHTVHVEQPRLFGKIVSEFLTSI*" /label="menH CDS" gene complement(2644190..2645014) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /label="menH gene" promotor_-10 complement(2644272..2644291) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2644272) /Source="Nicolas_upshifts" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2644307..2644310) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2644438) /Source="Nicolas_upshifts" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2644448..2644459) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2644474..2644480) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2645002..2646744) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /EC_number="2.2.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate decarboxylase and 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase" /protein_id="NP_390960.1" /db_xref="EnsemblGenomes-Gn:BSU30820" /db_xref="EnsemblGenomes-Tr:CAB15060" /db_xref="GOA:P23970" /db_xref="InterPro:IPR004433" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR032264" /db_xref="PDB:2X7J" /db_xref="SubtiList:BG10683" /db_xref="UniProtKB/Swiss-Prot:P23970" /translation="MTVNPITHYIGSFIDEFALSGITDAVVCPGSRSTPLAVLCAAHP DISVHVQIDERSAGFFALGLAKAKQRPVLLICTSGTAAANFYPAVVEAHYSRVPIIVL TADRPHELREVGAPQAINQHFLFGNFVKFFTDSALPEESPQMLRYIRTLASRAAGEAQ KRPMGPVHVNVPLREPLMPDLSDEPFGRMRTGRHVSVKTGTQSVDRESLSDVAEMLAE AEKGMIVCGELHSDADKENIIALSKALQYPILADPLSNLRNGVHDKSTVIDAYDSFLK DDELKRKLRPDVVIRFGPMPVSKPVFLWLKDDPTIQQIVIDEDGGWRDPTQASAHMIH CNASVFAEEIMAGLTAATRSSEWLEKWQFVNGRFREHLQTISSEDVSFEGNLYRILQH LVPENSSLFVGNSMPIRDVDTFFEKQDRPFRIYSNRGANGIDGVVSSAMGVCEGTKAP VTLVIGDLSFYHDLNGLLAAKKLGIPLTVILVNNDGGGIFSFLPQASEKTHFEDLFGT PTGLDFKHAAALYGGTYSCPASWDEFKTAYAPQADKPGLHLIEIKTDRQSRVQLHRDM LNEAVREVKKQWEL*" /label="menD CDS" gene complement(2645002..2646744) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /label="menD gene" CDS complement(2646741..2648156) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /EC_number="5.4.4.2" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinone-specific isochorismate synthase" /protein_id="NP_390961.1" /db_xref="EnsemblGenomes-Gn:BSU30830" /db_xref="EnsemblGenomes-Tr:CAB15061" /db_xref="GOA:P23973" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR034681" /db_xref="SubtiList:BG10682" /db_xref="UniProtKB/Swiss-Prot:P23973" /translation="MVTTVQRTFRKEVLHALHKAKEVNHAVLISYSRQIESLDPLSFF NYGAKKYTGNRFFWSDPESELTIVGLGKEAVFQTNQKNSERYREVFEQWERFKKTAFH IYEEEKLQHSAVGPVLFGGFSFDPCEERGSQWDHFSEGDFFVPALMLTMTAEGPFLTV NRWVSGGEDAEAVLEGLKAFAAEFMVPDFKQEDQAVIAAAEELDKDDWLKAIETATSQ IKEKQYDKVVLARELLLTFDGPIQIEPVLKTLLDDQQTSYVFAIEQEGKTFVGASPER LIKRDGGTVMSSCLAGSIKRGVNEEDDRRIGLELLNDEKNLLEHDIVVGMIHNAFVSS CSEVEKPDGPVLYKTKSVQHLFTPIVGQLRESASIFDLIEKLHPTPALGGSPQEKAVD VIREIEPMSRGWYAAPIGWIDSQDNGEFAVAIRSGLIEGSTARLFAGCGIVEDSEPIS EYEETQIKLKPMISALGGERR*" /label="menF CDS" gene complement(2646741..2648156) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /label="menF gene" S_feature complement(2648157..2648269) /Source="Nicolas_S_feature" /locus_tag="new_3153718_3153830_c" /HighExp="dia5, LBGstat, Diami, LBGtran, dia15, H2O2, G180, G150, LPhT, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1176" promotor_-10 complement(2648249..2648268) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-10" upshifts complement(2648269) /Source="Nicolas_upshifts" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="upshifts" S_feature complement(2648271..2648421) /Source="Nicolas_S_feature" /locus_tag="new_3153832_3153982_c" /HighExp="S8, S7, S6, S5, BT, S4, Pyr, B36, G/S, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1177" promotor_-35 complement(2648284..2648287) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-35" promotor_-35 2648382..2648388 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2648402..2648421) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2648402..2648413 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2648410 /Source="Nicolas_upshifts" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2648421) /Source="Nicolas_upshifts" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2648435..2648444) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2648446..2649165 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative regulatory protein" /protein_id="NP_390962.2" /db_xref="EnsemblGenomes-Gn:BSU30840" /db_xref="EnsemblGenomes-Tr:CAB15062" /db_xref="GOA:P42408" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR014240" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG11200" /db_xref="UniProtKB/Swiss-Prot:P42408" /translation="MLTKEQLQHLKNELEQTKKDILNRFKDNDHFQLNSAFPYDSWGE LSAYDNHPGDQATELYEREKDIALDLHEREHLRDIEHSLKAIENGTYGICEVSGKEIP FERLEALPTATTLAEYSSQDVVSKDRPIEEETPFGQFEFDDDEEIRAPYDSEDSYQDV EKYGNSQTPQDMENPPLSYDDMTMNAEENIGNTESYENFIATDITGKEITVYQSRAHE RYEEELDEEGIMTTFGDLHAD*" /label="yteA CDS" gene 2648446..2649165 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /label="yteA gene" S_feature complement(2648516..2649173) /Source="Nicolas_S_feature" /locus_tag="new_3154077_3154734_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, S3" /AntisenseName="yteA" /AntisenseCor="0.85796245341056299" /AntisenseRegPval="-78.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1178" downshifts 2649154 /Source="Nicolas_upshifts" /id="D1588" /incds=0 /nref=23 /ntot=40 /MaxReadThrough="0.72949" /MaxDrop="5.85132" /score="2.75726503" /energy="-10.1" /TU="NA" /idTUdmin="U2391" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2649174..2649992) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_390963.1" /db_xref="EnsemblGenomes-Gn:BSU30850" /db_xref="EnsemblGenomes-Tr:CAB15063" /db_xref="GOA:P42407" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11199" /db_xref="UniProtKB/Swiss-Prot:P42407" /translation="MIKKAIIPAGGFGTRNLPVTKVIPKEMFPVGSKPVIHYLVEELK ESGIEDILMVVSSHKNLIVDYFDSSLALEAFLASKNKLHLLREHPIPDIRIHYVRQPY AKGLGDAISFGKQFAGGEPFAVVLPDDLIFSANQPALGQLIEAYTKYQSSVIGLKETK TEDLHHYGVIKGEPVEKGLYRIQDIVEKPKQNPPSHFAAAGRYIFTPDIFNELEALEA DSGGEVQVTDAIKASLGACTVYGKLLEGERYDIGLQKDYLKLIYDMLKTEKNPQ*" /label="ytdA CDS" gene complement(2649174..2649992) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /label="ytdA gene" promotor_-10 complement(2650013..2650032) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2650027) /Source="Nicolas_upshifts" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2650047..2650055) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2650093..2650101 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2650114..2650133 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2650115 /Source="Nicolas_upshifts" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="upshifts" CDS 2650164..2651450 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /EC_number="1.1.1.22" /function="16.14: Store" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose dehydrogenase" /protein_id="NP_390964.1" /db_xref="EnsemblGenomes-Gn:BSU30860" /db_xref="EnsemblGenomes-Tr:CAB15064" /db_xref="GOA:O34862" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13828" /db_xref="UniProtKB/Swiss-Prot:O34862" /translation="MKICVVGAGYVGLTLSAALASIGHDMICTDKDVKKIGQLKKGVI PFYEPGLSDAILRCGNLSFSSEVKSSMEECPVIFIAVGTPPRSDGSADTKALQSVIGD LSEAIRSYKTIITKSTVPPGTNENIAKQLIASGVSKNLFNIVSNPEFLREGNALYDML HPDKTVIGVQEEDHVSAAIVKSIYKHIDTPFIVTSLAGAELIKYANNFFLAAKISFIN EMARICEAYQSDISDISRAIGLDPRIGKHFLQAGIGYGGSCFPKDLQALQFAAQEKNT ETFLLRAVQHINDTQLGLYIKKIQSFFETLQGKKAAVLGISFKPNTDDIRNSQAVRLM ERLAELGCDVHAYDPEAVLPEHLRQHVTQHSQAFDAIEESDFLFLATEWSEFLAFDWK KAADIMKGRLVIDGRNVLKKELIEACGLICTGVGRP*" /label="ytcA CDS" gene 2650164..2651450 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /label="ytcA gene" CDS 2651447..2652397 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose epimerase" /protein_id="NP_390965.1" /db_xref="EnsemblGenomes-Gn:BSU30870" /db_xref="EnsemblGenomes-Tr:CAB15065" /db_xref="GOA:O34886" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13829" /db_xref="UniProtKB/Swiss-Prot:O34886" /translation="MKILVTGAAGFIGSHLCEELLKDKKHNVIGIDDFIGPTPFSLKL KNLKNLLPEKRFTFIKENLLTADLASLLEGVDVIFHLAAIPGVRSSWGNHFHPYAAHN IQALQRLLEACREHSIQTFVFASTSSVYGEKQGKVSENTSLSPLSPYGVTKLTGEKLC HVYKQSFGIPIVILRFFTVYGPRQRPDMAFHRLIKQHLQQKPLTIFGDGQQSRDFTYI SDCVKGITAVLGKPHLIGETVNIGGAERASVLKVVSLIEDISGRKATLHFSDKIAGEP SNTWADISKAKQLLHYDPATSLKDGLTNEIAYLSSLYQGE*" /label="ytcB CDS" gene 2651447..2652397 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /label="ytcB gene" CDS 2652400..2653623 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /EC_number="2.4.1.-" /function="16.14: Store" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glucosyltransferase" /protein_id="NP_390966.1" /db_xref="EnsemblGenomes-Gn:BSU30880" /db_xref="EnsemblGenomes-Tr:CAB15066" /db_xref="GOA:O34413" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG13830" /db_xref="UniProtKB/Swiss-Prot:O34413" /translation="MKLAFICTEKLPAPAVRGGAIQMMIDGVTPYFSSRYDLTIFSIE DPSLPKRETKDGVHYIHLPKEHYREAVAEELRASSFDLIHVFNRPLNVSLYKKASPNS KIVLSLHNEMFSEKKMTFAQGKEVLDNVSMITTVSEFIKQTVIERFPEAEDITKVVYS GVDLNSYPPVWTMKGSAVRKTYRKKYGIEDKKVILFAGRLSPTKGPHLLIHSMRRILQ QHPDAVLVIAGGKWFSDDSENQYVTYLRTLALPYRDHIIFTKFIPADDIPNLFLMADV FVCSSQWNEPLARVNYEAMAAGTPLITTNRGGNGEVVKHEVTGLVIDSYNKPSSFAKA IDRAFTDQELMNKMTKNARKHVEALFTFTHAAKRLNTVYQSVLTPKNKQFPPPFLTQN FDLSSINQLFVKAKT*" /label="ytcC CDS" gene 2652400..2653623 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /label="ytcC gene" downshifts complement(2653547) /Source="Nicolas_upshifts" /id="D1589" /incds=1 /nref=1 /ntot=10 /MaxReadThrough="1.32025" /MaxDrop="3.47267" /score="-3.65321449" /energy="-3.1" /TU="NA" /idTUdmin="U2395" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2653624..2654191 /Source="Nicolas_S_feature" /locus_tag="new_3159185_3159752" /HighExp="S8, S7, BT, S6, C30, Pyr, S5, G/S, C90, Glucon" /AntisenseName="ytxO" /AntisenseCor="0.86121563743373297" /AntisenseRegPval="-79.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1179" CDS complement(2653697..2654128) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="outer spore coat protein" /protein_id="NP_390967.1" /db_xref="EnsemblGenomes-Gn:BSU30890" /db_xref="EnsemblGenomes-Tr:CAB15067" /db_xref="SubtiList:BG11382" /db_xref="UniProtKB/Swiss-Prot:P46916" /translation="MRSSRQKASISKLDLDQFVFTPPGPMGWQAHDSISAEKEEEEKH LDVGSIRELPHINAPKEYQKETKEKETDRKIVDDEEETKFETTLEPEEERDSKRSAPP YEEEDEDEEPDLAEEAKVEIIILPSESKPAPWFSQTVKRKA*" /label="cotOO CDS" gene complement(2653697..2654128) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /label="cotOO gene" downshifts complement(2653723) /Source="Nicolas_upshifts" /id="D1590" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="3.07378" /MaxDrop="4.8822" /score="9.30990044" /energy="-8.3" /TU="U2395" /idTUdmin="U2395" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(2654130..2655185) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7545510, 9603889, 10234840, 11737650, 14702409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7545510, 9603889, 10234840, 11737650, 14702409; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390968.1" /db_xref="EnsemblGenomes-Gn:BSU30900" /db_xref="EnsemblGenomes-Tr:CAB15068" /db_xref="GOA:P46914" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="SubtiList:BG11380" /db_xref="UniProtKB/Swiss-Prot:P46914" /translation="MYQKEHEEQIVSEILSYYPFHIDHVALKSNKSGRKIWEVETDHG PKLLKEAQMKPERMLFITQAHAHLQEKGLPIAPIHQTKNGGSCLGTDQVSYSLYDKVT GKEMIYYDAEQMKKVMSFAGHFHHASKGYVCTDESKKRSRLGKWHKLYRWKLQELEGN MQIAASYPDDVFSQTFLKHADKMLARGKEALRALDDSEYETWTKETLEHGGFCFQDFT LARLTEIEGEPFLKELHSITYDLPSRDLRILLNKVMVKLSVWDTDFMVALLAAYDAVY PLTEKQYEVLWIDLAFPHLFCAIGHKYYLKQKKTWSDEKYNWALQNMISVEESKDSFL DKLPELYKKIKAYREAN*" /label="cotS CDS" gene complement(2654130..2655185) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /label="cotS gene" CDS complement(2655200..2656333) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9603889, 10234840, 11737650" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9603889, 10234840, 11737650; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390969.1" /db_xref="EnsemblGenomes-Gn:BSU30910" /db_xref="EnsemblGenomes-Tr:CAB15069" /db_xref="GOA:P46915" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11381" /db_xref="UniProtKB/Swiss-Prot:P46915" /translation="MKIALIATEKLPVPSVRGGAIQIYLEAVAPLIAKKHEVTVFSIK DPNLADREKVDGVHYVHLDEDRYEEAVGAELKKSRFDLVHVCNRPSWVPKLKKQAPDA VFILSVHNEMFAYDKISQAEGEICIDSVAQIVTVSDYIGQTITSRFPSARSKTKTVYS GVDLKTYHPRWTNEGQRAREEMRSELGLHGKKIVLFVGRLSKVKGPHILLQALPDIIE EHPDVMMVFIGSKWFGDNELNNYVKHLHTLGAMQKDHVTFIQFVKPKDIPRLYTMSDV FVCSSQWQEPLARVHYEAMAAGLPIITSNRGGNPEVIEEGKNGYIIHDFENPKQYAER INDLLSSSEKRERLGKYSRREAESNFGWQRVAENLLSVYEKNR*" /label="cotSA CDS" gene complement(2655200..2656333) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /label="cotSA gene" promotor_-10 complement(2656366..2656385) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2656385) /Source="Nicolas_upshifts" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2656398..2656407) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2656471..2656480 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2656494..2656513 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2656496 /Source="Nicolas_upshifts" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="upshifts" CDS 2656523..2657596 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816, 20077512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 20077512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat kinase" /protein_id="NP_390970.1" /db_xref="EnsemblGenomes-Gn:BSU30920" /db_xref="EnsemblGenomes-Tr:CAB15070" /db_xref="GOA:O34656" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="PDB:2Q83" /db_xref="SubtiList:BG13821" /db_xref="UniProtKB/Swiss-Prot:O34656" /translation="MCPLMAENHEVIEEGNSSELPLSAEDAKKLTELAENVLQGWDVQ AEKIDVIQGNQMALVWKVHTDSGAVCLKRIHRPEKKALFSIFAQDYLAKKGMNVPGIL PNKKGSLYSKHGSFLFVVYDWIEGRPFELTVKQDLEFIMKGLADFHTASVGYQPPNGV PIFTKLGRWPNHYTKRCKQMETWKLMAEAEKEDPFSQLYLQEIDGFIEDGLRIKDRLL QSTYVPWTEQLKKSPNLCHQDYGTGNTLLGENEQIWVIDLDTVSFDLPIRDLRKMIIP LLDTTGVWDDETFNVMLNAYESRAPLTEEQKQVMFIDMLFPYELYDVIREKYVRKSAL PKEELESAFEYERIKANALRQLI*" /label="cotI CDS" gene 2656523..2657596 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /label="cotI gene" promotor_-35 2656820..2656826 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2656837 /Source="Nicolas_upshifts" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2656840..2656851 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2657585 /Source="Nicolas_upshifts" /id="D1591" /incds=0 /nref=16 /ntot=35 /MaxReadThrough="3.14769" /MaxDrop="5.1897" /score="-2.47616606" /energy="-10.3" /TU="U2396,U2397" /idTUdmin="U2396" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2657623..2657629 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2657644 /Source="Nicolas_upshifts" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2657645..2657663 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2657676..2658143 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717291, 15849754, 16850406; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative receptor" /protein_id="NP_390971.1" /db_xref="EnsemblGenomes-Gn:BSU30930" /db_xref="EnsemblGenomes-Tr:CAB15071" /db_xref="GOA:O34694" /db_xref="InterPro:IPR004307" /db_xref="SubtiList:BG13822" /db_xref="UniProtKB/Swiss-Prot:O34694" /translation="MKKIVGALAVFVITYALFSAAGYLFPVDQEWYNSLKKPDWTPSG TAIGIIWAILFALISLSAAIVYAAFSFKGAKSFWFTLLINYVLNQAFSYFQFTQKNLL AASLDCLLVAITAIVLLIIAKKYSRAASYLLLPYFLWSAFATFLSFTINSMNL*" /label="ytaB CDS" gene 2657676..2658143 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /label="ytaB gene" downshifts 2658115 /Source="Nicolas_upshifts" /id="D1592" /incds=0 /nref=43 /ntot=123 /MaxReadThrough="2.47485" /MaxDrop="5.7907" /score="9.10214462" /energy="-10.1" /TU="NA" /idTUdmin="U2396" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2658174..2660570) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /EC_number="2.4.1.1" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8145641, 9244254, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen phosphorylase" /protein_id="NP_390972.1" /db_xref="EnsemblGenomes-Gn:BSU30940" /db_xref="EnsemblGenomes-Tr:CAB15072" /db_xref="GOA:P39123" /db_xref="InterPro:IPR000811" /db_xref="InterPro:IPR011833" /db_xref="InterPro:IPR035090" /db_xref="SubtiList:BG10911" /db_xref="UniProtKB/Swiss-Prot:P39123" /translation="MFSSKERFADLFLKRLEMTCGKSFKDSAKLDQYKTLGNMVREYI SADWIETNEKSRSNSGKQTYYLSIEFLLGQLLEQNLMNLGVRDVVEAGLKEIGINLEE ILQIENDAGLGNGGLGRLAACFLDSLASLNLPGHGMGIRYKHGLFEQKIVDGHQVELP EQWLKNGNVWEVRNADQAVDVPFWGEVHMTEKSGRLHFRHEQATIVTAVPYDIPIIGY ETGTVNTLRLWNAEPYAHYHGGNILSYKRETEAVSEFLYPDDTHDEGKILRLKQQYFL VCASLKSIVNNYRKTHKSLSGLHKKVSIHINDTHPALAVPELMRILLDEENMSWEEAW HITVHTISYTNHTTLSEALEKWPIHLFKPLLPRMYMIIEEINERFCRAVWEKYPGDWK RIENMAITAHGVVKMAHLAIVGSYSVNGVAKIHSDILKEREMRDFHLLFPNRFNNKTN GIAHRRWLLKANPGLSAIITEAIGDEWVKQPESLIRLEPYATDPAFIEQFQNNKSKKK QELADLIFCTAGVVVNPESIFDVQVKRLHAYKRQLLNVLHIMYLYNRLKEDSGFSIYP QTFIFGAKASPSYYYAKKIIKLIHSVAEKVNYDPAVKQLIKVVFLENYRVSMAERIFP ASDVSEQISTASKEASGTGNMKFMMNGALTIGTHDGANIEILERVGPDCIYTFGLKAD EVLSYQENGGYRSREYYQHDRRIRQVADQLINGFFEGEADEFESIFDSLLPHNDEYFV LKDFSSYADAQERIQADYRERRKWSEHSIVNIAHSGYFSSDRTIREYAKDIWGIKPMM *" /label="glgP CDS" gene complement(2658174..2660570) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /label="glgP gene" downshifts complement(2658189) /Source="Nicolas_upshifts" /id="D1593" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="2.31076" /MaxDrop="4.39135" /score="34.694666" /energy="-10.1" /TU="NA" /idTUdmin="U2399" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2660557..2662011) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /EC_number="2.4.1.21" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:8145641, 15272305" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8145641, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen (starch) synthase" /protein_id="NP_390973.1" /db_xref="EnsemblGenomes-Gn:BSU30950" /db_xref="EnsemblGenomes-Tr:CAB15073" /db_xref="GOA:P39125" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR011835" /db_xref="InterPro:IPR013534" /db_xref="SubtiList:BG10910" /db_xref="UniProtKB/Swiss-Prot:P39125" /translation="MKILFAVSECTPFVKSGGLADVAGALPKALARLGNEVAVMLPKY SQIPEPWKKRMKKQAECTVAVGWRQQYCGIEHMAENDVNYYFIDNEYYFNRDSLYGHY DDGERFAFFSRAVLEAAKVVNVQADIVHTHDWHTAMVNYLLKEEYRKHPFYERMKSVL TIHNLQFQGIFPPDVTHDLLGLEMDHFHYERLECNGFVNFMKAGIIAADHVTTVSPTY RNEIMTPYYGEQLEQVLQYREDDVTGILNGIDDTFYQPKSDPYIEAQYDSGDLACKLE NKTKLQQRMGLPEKNDIPLISMVTRLTKQKGLDLVRRIMHELLEEQDIQLVVLGTGER EFEDYFRYAEFAFHEKCRAYIGFDEPLAHQIYAGSDMFLMPSKFEPCGLGQLIALQYG AIPIVRETGGLYDTVRAYQEEEGTGNGFTFSAFNAHDLKFTIERALSFYCQQDVWKSI VKTAMNADYSWGKSAKEYQRIFEQVTRSGRDVLE*" /label="glgA CDS" gene complement(2660557..2662011) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /label="glgA gene" CDS complement(2662008..2663039) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) beta subunit" /protein_id="NP_390974.1" /db_xref="EnsemblGenomes-Gn:BSU30960" /db_xref="EnsemblGenomes-Tr:CAB15074" /db_xref="GOA:P39124" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011832" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10909" /db_xref="UniProtKB/Swiss-Prot:P39124" /translation="MFNNQMLGVIDETTYKHSLQDLTAQRSLGAIPFAGRYRLIDFML SNMVNADIRSVAIFPKYRYRSLMDHLGAGKEWDLHRKKDGLFFFPSPHLHHEYDEFGS FRQFSDHLDYFHRSTQQYAVISNSHTVCNIQFQYVLKRHQEVGCDVTEVFQDGQSLQI YIMSTTLLKDLIYGHSEKGYKTIQEAVEKESSALTICPYEYSGYAAVIDSVEKYYTHS MELIQPRFWQQVFLPQQPIYTKVKDEPPTKYGKHSTVKNSLVANGCVLEGEVENCILF RAVHVGKGTKLKNCIIMQKTQIGEDCLLEQVISDKDVKIGKATEAAGTAEQPLVLRKG LVQGELMNS*" /label="glgD CDS" gene complement(2662008..2663039) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /label="glgD gene" CDS complement(2663063..2664205) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) subunit alpha" /protein_id="NP_390975.1" /db_xref="EnsemblGenomes-Gn:BSU30970" /db_xref="EnsemblGenomes-Tr:CAB15075" /db_xref="GOA:P39122" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005836" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011831" /db_xref="InterPro:IPR023049" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10908" /db_xref="UniProtKB/Swiss-Prot:P39122" /translation="MKKQCVAMLLAGGKGSRLSGLTKNMAKPAVSFGGKYRIIDFTLS NCSNSGIDTVGILTQYQPLELNSYIGIGSAWDLDRYNGGVTVLPPYAESSEVKWYKGT ASSIYENLNYLNQYDPEYVLILSGDHIYKMDYGKMLDYHIEKKADVTISVIEVGWEEA SRFGIMKANPDGTITHFDEKPKFPKSNLASMGIYIFNWPLLKQYLEMDDQNPYSSHDF GKDIIPLLLEEKKKLSAYPFKGYWKDVGTVQSLWEANMDLLKEDSELKLFERKWKIYS VNPNQPPQFISSDAQVQDSLVNEGCVVYGNVSHSVLFQGVTVGKHTTVTSSVIMPDVT IGEHVVIENAIVPNGMVLPDGAVIRSEKDIEEVLLVSEEFVEKELI*" /label="glgC CDS" gene complement(2663063..2664205) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /label="glgC gene" CDS complement(2664202..2666085) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /EC_number="2.4.1.18" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1296817, 15272305, 8145641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-alpha-glucan branching enzyme" /protein_id="NP_390976.1" /db_xref="EnsemblGenomes-Gn:BSU30980" /db_xref="EnsemblGenomes-Tr:CAB15076" /db_xref="GOA:P39118" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR006048" /db_xref="InterPro:IPR006407" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG10907" /db_xref="UniProtKB/Swiss-Prot:P39118" /translation="MAAASPTAHDVYLFHEGSLFKSYQLFGSHYRELNGKSGYEFCVW APHASEVRVAGDFNSWSGEEHVMHRVNDNGIWTLFIPGIGEKERYKYEIVTNNGEIRL KADPYAIYSEVRPNTASLTYDLEGYSWQDQKWQKKQKAKTLYEKPVFIYELHLGSWKK HSDGRHYSYKELSQTLIPYIKKHGFTHIELLPVYEHPYDRSWGYQGTGYYSPTSRFGP PHDLMKFVDECHQQNIGVILDWVPGHFCKDAHGLYMFDGEPLYEYKEERDRENWLWGT ANFDLGKPEVHSFLISNALYWAEFYHIDGFRVDAVANILYWPNQDERHTNPYAVDFLK KLNQTMREAYPHVMMIAEDSTEWPQVTGAVEEGGLGFHYKWNMGWMNDVLKYMETPPE ERRHCHQLISFSLLYAFSEHFVLPFSHDEVVYGKKSLLNKMPGDYWQKFAQYRLLLGY MTVHPGKKLIFMGSEFAQFDEWKDTEQLDWFLDSFPMHQKASVFTQDLLRFYQKSKIL YEHDHRAQSFEWIDVHNDEQSIFSFIRYGQKHGEALVIICNFTPVVYHQYDVGVPFFT QYIEVLNSDSETYGGSGQINKKPLSAKKGALHHKPCYITMTIPPYGISILRAVKKRGE IKR*" /label="glgB CDS" gene complement(2664202..2666085) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /label="glgB gene" S_feature 2664911..2666330 /Source="Nicolas_S_feature" /locus_tag="new_3170472_3171891" /HighExp="S8, S7, S6, C30, BT, Pyr, G/S, S2, C90, BC" /AntisenseName="glgB" /AntisenseCor="0.59299722159013002" /AntisenseRegPval="-26.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1180" promotor_-10 complement(2666117..2666132) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2666130) /Source="Nicolas_upshifts" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2666147..2666152) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2666197) /Source="Nicolas_upshifts" /id="D1594" /incds=0 /nref=2 /ntot=46 /MaxReadThrough="1.66182" /MaxDrop="3.12741" /score="36.0363304" /energy="-9.2" /TU="NA" /idTUdmin="U2401" /TUdmin=198 /isTUend="FALSE" /label="downshifts" tRNA complement(2666318..2666389) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Glu tRNA" gene complement(2666318..2666389) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /label="trnB-Glu gene" tRNA complement(2666415..2666505) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser2 tRNA" gene complement(2666415..2666505) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /label="trnB-Ser2 gene" tRNA complement(2666509..2666583) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asn tRNA" gene complement(2666509..2666583) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /label="trnB-Asn gene" tRNA complement(2666594..2666670) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ile2 tRNA" gene complement(2666594..2666670) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /label="trnB-Ile2 gene" tRNA complement(2666686..2666759) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly2 tRNA" gene complement(2666686..2666759) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /label="trnB-Gly2 gene" tRNA complement(2666770..2666845) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-His tRNA" gene complement(2666770..2666845) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /label="trnB-His gene" tRNA complement(2666863..2666938) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Phe tRNA" gene complement(2666863..2666938) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /label="trnB-Phe gene" tRNA complement(2666951..2667027) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asp tRNA" gene complement(2666951..2667027) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /label="trnB-Asp gene" tRNA complement(2667039..2667115) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met2 tRNA" gene complement(2667039..2667115) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /label="trnB-Met2 gene" tRNA complement(2667133..2667225) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser1 tRNA" gene complement(2667133..2667225) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /label="trnB-Ser1 gene" tRNA complement(2667232..2667308) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met3 tRNA" gene complement(2667232..2667308) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /label="trnB-Met3 gene" tRNA complement(2667311..2667387) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met1 tRNA" gene complement(2667311..2667387) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /label="trnB-Met1 gene" tRNA complement(2667407..2667479) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ala tRNA" gene complement(2667407..2667479) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /label="trnB-Ala gene" tRNA complement(2667485..2667561) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Pro tRNA" gene complement(2667485..2667561) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /label="trnB-Pro gene" tRNA complement(2667577..2667653) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Arg tRNA" gene complement(2667577..2667653) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /label="trnB-Arg gene" tRNA complement(2667663..2667748) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu2 tRNA" gene complement(2667663..2667748) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /label="trnB-Leu2 gene" tRNA complement(2667763..2667837) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly1 tRNA" gene complement(2667763..2667837) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /label="trnB-Gly1 gene" tRNA complement(2667843..2667929) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu1 tRNA" gene complement(2667843..2667929) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /label="trnB-Leu1 gene" tRNA complement(2667940..2668015) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Lys tRNA" gene complement(2667940..2668015) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /label="trnB-Lys gene" tRNA complement(2668053..2668128) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Thr tRNA" gene complement(2668053..2668128) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /label="trnB-Thr gene" tRNA complement(2668161..2668236) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Val tRNA" gene complement(2668161..2668236) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /label="trnB-Val gene" rRNA complement(2668257..2668374) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-5S rRNA" gene complement(2668257..2668374) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /label="rrnB-5S gene" rRNA complement(2668430..2671357) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-23S rRNA" gene complement(2668430..2671357) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /label="rrnB-23S gene" rRNA complement(2671525..2673079) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-16S rRNA" gene complement(2671525..2673079) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /label="rrnB-16S gene" Polymorphism join(2672881,2672883) /Source="geneious" /ID="SNP_BsDelta6_3178443_3178443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="T -> C" /Codon_Change /Coverage=95 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="3.5e-102" /Variant_Raw_Frequency=94 /comment="rrnB-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" S_feature complement(2673080..2673371) /Source="Nicolas_S_feature" /locus_tag="new_3178641_3178932_c" /HighExp="Diami, LPhT, C30, LBGstat, HPh, GM 120, Oxctl, Paraq, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40784100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1181" misc_feature 2673207..2673215 /Source="Nicolas_upshift_promotors" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2673213 /Source="Nicolas_upshifts" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2673323 /Source="Nicolas_upshifts" /id="D1595" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="2.91899" /MaxDrop="4.63941" /score="-0.368124787" /energy="-10.2" /TU="U2400" /idTUdmin="U2400" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2673344..2673363) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2673371) /Source="Nicolas_upshifts" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2673373..2674339) /Source="Nicolas_S_feature" /locus_tag="new_3178934_3179900_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T0.0H, T3.0H, T-0.40H, S8, T3.30H" /AntisenseName="thiT" /AntisenseCor="-0.219467435413819" /AntisenseRegPval="-3.5" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1182" promotor_-35 complement(2673377..2673384) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2673496..2673499 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2673511 /Source="Nicolas_upshifts" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2673514..2673533 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2673544..2673645 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswC RNA" gene 2673544..2673645 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /label="tswC gene" downshifts 2673644 /Source="Nicolas_upshifts" /id="D1596" /incds=0 /nref=47 /ntot=135 /MaxReadThrough="5.85975" /MaxDrop="7.03111" /score="-0.368124787" /energy="-10.2" /TU="U2402" /idTUdmin="U2400" /TUdmin=299 /isTUend="FALSE" /label="downshifts" CDS 2673745..2674323 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 19181806" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 19181806; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamin permease" /protein_id="NP_390977.1" /db_xref="EnsemblGenomes-Gn:BSU30990" /db_xref="EnsemblGenomes-Tr:CAB15077" /db_xref="GOA:O32074" /db_xref="InterPro:IPR012651" /db_xref="SubtiList:BG13949" /db_xref="UniProtKB/Swiss-Prot:O32074" /translation="MNQSKQLVRLIEIAIMTAAAVILDIVSGMFLSMPQGGSVSIMMI PIFLISFRWGVKAGLTTGLLTGLVQIAIGNLFAQHPVQLLLDYIVAFAAIGISGCFAS SVRKAAVSKTKGKLIVSVVSAVFIGSLLRYAAHVISGAVFFGSFAPKGTPVWIYSLTY NATYMVPSFIICAIVLCLLFMTAPRLLKSDKA*" /label="thiT CDS" gene 2673745..2674323 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /label="thiT gene" downshifts 2674313 /Source="Nicolas_upshifts" /id="D1597" /incds=0 /nref=129 /ntot=206 /MaxReadThrough="1.91553" /MaxDrop="5.49387" /score="35.5376279" /energy="-19.5" /TU="NA" /idTUdmin="U2402" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2674365..2674886) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390978.1" /db_xref="EnsemblGenomes-Gn:BSU31000" /db_xref="EnsemblGenomes-Tr:CAB15078" /db_xref="GOA:O32075" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13948" /db_xref="UniProtKB/Swiss-Prot:O32075" /translation="MVTVREAKLEDIKDIAKVHVDSWRTTYHEIIPIDYLNSLNYKEF EDKWKSRSLKGVFVAQDEKGSVFGFASFGPIRSEQEGYDGELYAIYLLEERQRQGAGR ALLAKGAEFLLQHGFSSMFVWVIEQNPSIIFYQAYSPERVAEDNFEIAGVRLKEVGLG WPDLSALKTLLNR*" /label="yuaI CDS" gene complement(2674365..2674886) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /label="yuaI gene" downshifts complement(2674383) /Source="Nicolas_upshifts" /id="D1598" /incds=0 /nref=8 /ntot=143 /MaxReadThrough="6.18352" /MaxDrop="5.43101" /score="13.1646679" /energy="-19.6" /TU="U2403" /idTUdmin="U2405" /TUdmin=6 /isTUend="TRUE" /label="downshifts" downshifts complement(2674455) /Source="Nicolas_upshifts" /id="D1599" /incds=1 /nref=8 /ntot=208 /MaxReadThrough="8.2849" /MaxDrop="3.3545" /score="13.1646679" /energy="-19.6" /TU="U2403,U2405" /idTUdmin="U2405" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2674904..2676433) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /experiment="publication(s) with functional evidences, PMID:9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845; Product type s: structure" /codon_start=1 /transl_table=11 /product="flotillin lipid rafts scaffold protein" /protein_id="NP_390979.1" /db_xref="EnsemblGenomes-Gn:BSU31010" /db_xref="EnsemblGenomes-Tr:CAB15079" /db_xref="GOA:O32076" /db_xref="InterPro:IPR001107" /db_xref="InterPro:IPR027705" /db_xref="InterPro:IPR031905" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG13947" /db_xref="UniProtKB/Swiss-Prot:O32076" /translation="MTMPIIMIIGVVFFLLIALIAVFITKYRTAGPDEALIVTGSYLG NKNVHVDEGGNRIKIVRGGGTFVLPVFQQAEPLSLLSSKLDVSTPEVYTEQGVPVMAD GTAIIKIGGSIGEIATAAEQFLGKSKDDREQEAREVLEGHLRSILGSMTVEEIYKNRE KFSQEVQRVASQDLAKMGLVIVSFTIKDVRDKNGYLESLGKPRIAQVKRDADIATAEA DKETRIKRAEADKDAKKSELERATEIAEAEKINQLKMAEFRREQDTAKANADQAYDLE TARARQQVTEQEMQVKIIERQKQIELEEKEILRRERQYDSEVKKKADADRYSVEQSAA AEKAKQLAEADAKKYSIEAMAKAEAEKVRIDGLAKAEAEKAKGETEAEVIRLKGLAEA EAKEKIAAAFEQYGQAAIFDMIVKMLPEYAKQAAAPLSNIDKITVVDTGGSGESSGAN KVTSYATNLMSSLQESLKASSGIDVKEMLENFSGKGNVKQSINELTNEIKEAKTIQKS E*" /label="floT CDS" gene complement(2674904..2676433) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /label="floT gene" CDS complement(2676454..2676978) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12533473, 15849754, 16850406, 18696230, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane integrity integral membrane protein" /protein_id="NP_390980.1" /db_xref="EnsemblGenomes-Gn:BSU31020" /db_xref="EnsemblGenomes-Tr:CAB15080" /db_xref="GOA:O32077" /db_xref="PDB:2K14" /db_xref="SubtiList:BG13946" /db_xref="UniProtKB/Swiss-Prot:O32077" /translation="MELFGVPIQTMYLYTLIIAGSLTLLFLFFGDVFSGLSEGIPFLN PTLVLSFFTCFSAGGYIGELVLPLSSLLIALLSCILSIMLVVLLHIFVLVPLSSAEES LAYREDDLRGRLGKVITAVPVDGFGEVVIEGIGGTISKSAVSFDNQQISYGTTVLVVD INNGVLSVTPHEPI*" /label="nfeDB CDS" gene complement(2676454..2676978) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /label="nfeDB gene" promotor_-10 complement(2677022..2677037) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-10" upshifts complement(2677028) /Source="Nicolas_upshifts" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="upshifts" S_feature complement(2677030..2677117) /Source="Nicolas_S_feature" /locus_tag="new_3182591_3182678_c" /HighExp="S4, S8, S6, S7, S5, S3, B36, LoTm, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S1183" promotor_-35 complement(2677049..2677058) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-35" promotor_-10 complement(2677102..2677120) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2677112 /Source="Nicolas_upshifts" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2677116..2677135 /Source="Nicolas_upshift_promotors" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2677117) /Source="Nicolas_upshifts" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2677135..2677140) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2677146..2677634 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390981.1" /db_xref="EnsemblGenomes-Gn:BSU31030" /db_xref="EnsemblGenomes-Tr:CAB15081" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG13945" /db_xref="UniProtKB/Swiss-Prot:O32078" /translation="MSIFNEARLETWNELKGLSDEKLNQKPSAEEWSIREVLDHLKKI DMTAQKMLKERVKDAPIKEIEEKPLEVAQDRNNKRKAPSHLEPAHDFISGSQMKRELD VVREQLTAAIASLKEEDFERVLPHPVFQELTVRQWIDFIGHHEKRHLSQMKEIKEKIE RA*" /label="yuaE CDS" gene 2677146..2677634 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /label="yuaE gene" downshifts 2677611 /Source="Nicolas_upshifts" /id="D1600" /incds=0 /nref=205 /ntot=267 /MaxReadThrough="4.05856" /MaxDrop="6.05192" /score="-4.20632485" /energy="-15" /TU="U2404" /idTUdmin="U2404" /TUdmin="-354" /isTUend="FALSE" /label="downshifts" CDS complement(2677640..2678218) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11886751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390982.1" /db_xref="EnsemblGenomes-Gn:BSU31040" /db_xref="EnsemblGenomes-Tr:CAB15082" /db_xref="GOA:O32079" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="PDB:1ORU" /db_xref="SubtiList:BG13944" /db_xref="UniProtKB/Swiss-Prot:O32079" /translation="MWKRMTAKAEGLYIADTKSFVTKQMDKLDFDYGGIPGDLHFGLT KKAGAREPMFSRGTEIFNRRQISIVSIEECNEIALKMGVPRILPEWLGANVAVSGMPD LTSLKEGSRIIFPSGAALLCEGENDPCIQPGEVIQSYYPDQPKLASAFVRHALGIRGI VCIVERPGAVYTGDEIEVHSYQRKVKRKAERV*" /label="yuaD CDS" gene complement(2677640..2678218) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /label="yuaD gene" S_feature 2677656..2678047 /Source="Nicolas_S_feature" /locus_tag="new_3183217_3183608" /HighExp="Etha, S8, LPhT, S6, Salt, LoTm, S5, H2O2, S7, dia5" /AntisenseName="yuaD" /AntisenseCor="-0.48344313728748101" /AntisenseRegPval="-16.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S1184" downshifts complement(2677667) /Source="Nicolas_upshifts" /id="D1601" /incds=0 /nref=87 /ntot=222 /MaxReadThrough="0.58189" /MaxDrop="3.9885" /score="0.718873117" /energy="-11.5" /TU="NA" /idTUdmin="U2406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2678252..2678271) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2678261) /Source="Nicolas_upshifts" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2678285..2678292) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2678306..2679514) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /EC_number="1.1.99.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="choline dehydrogenase" /protein_id="NP_390983.2" /db_xref="EnsemblGenomes-Gn:BSU31050" /db_xref="EnsemblGenomes-Tr:CAB15083" /db_xref="GOA:P71017" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG11941" /db_xref="UniProtKB/Swiss-Prot:P71017" /translation="MTLNMKVESMQKFHTFEIPTVIKHGIGAIKHTGEEVAALGVSKA LLVTDPGIYKAGVADPVIESLKEAGIEVVLFNKVEPNPPVRLVNEGSELYKKENCNGL VAVGGGSSMDTAKAIGVEATHEGSVLDYEAADGKKPLENRIPPLTTIPTTAGTGSEVT QWAVITDEEREFKFNTGGPLIAAHLTIIDPELHVSMPPHVTAMTGIDALAHAIECYTM KFAQPITDAVALMAIEYAAHYIKRAFADGEDLEARYGMAQAAMLAGLSYGSESAGAAH AMSQTLGGIIPVAHGQCVAAMMGPVMEYNWKGYPEKFARIAKAFGIDTSKMTTEEAAK ASVNWMYDLVEDLEVPTLEEQGVSPDMIERLSKEAMKDPQTFGNPRDLNEKAYNWIYK RCFNLTPKTV*" /label="gbsB CDS" gene complement(2678306..2679514) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /label="gbsB gene" downshifts complement(2678327) /Source="Nicolas_upshifts" /id="D1602" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="2.9443" /MaxDrop="3.26923" /score="18.315772" /energy="-13.6" /TU="NA" /idTUdmin="U2406" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2679283..2679302) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2679295) /Source="Nicolas_upshifts" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2679317..2679324) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2679531..2681003) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /EC_number="1.2.1.8" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 9297465, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 9297465, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine betaine aldehyde dehydrogenase, NAD+-dependent" /protein_id="NP_390984.1" /db_xref="EnsemblGenomes-Gn:BSU31060" /db_xref="EnsemblGenomes-Tr:CAB15084" /db_xref="GOA:P71016" /db_xref="InterPro:IPR011264" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11940" /db_xref="UniProtKB/Swiss-Prot:P71016" /translation="MSQTLFIDGEWISAEKEQIRSIINPFNQEEIATVSEGGREDAIK AIAAARRAFDKGEWSSLSGLERGKIVLKIAELIRRDLEELAELESLDTGKTLEESKAD MDDIANVFQYYAGLADKDGGEIISSPIPDSESKIIREPIGVCGQITPWNYPLLQASWK IAPALAAGNTIVMKPSEITPLTTIKVFKLMEEAGVPKGVANLVLGPGATVGDELAVNK DVDLISFTGGIETGKKIMRAASGNVKKIALELGGKNPNIVFKDADLEVAVDQALNAVF FHAGQVCSAGSRLLVEDAIHDQFLAELVKRAKRIKLGNGFHAETESGPLISAEHRAKV EKYVEIGIEEGAKLETGGKRPEDPELQNGFFYEPTIFSNCNSDMRIVQEEVFGPVLTV ETFSSEEEVIELANDTIYGLAGAVWSKDIEKCERVAARLRMGTVWINDFHPYFAQAPW GGYKQSGFGRELGKIGLEEYTEVKHVYRNTKPAAVNWFNS*" /label="gbsA CDS" gene complement(2679531..2681003) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /label="gbsA gene" promotor_-10 complement(2681054..2681073) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2681055) /Source="Nicolas_upshifts" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2681088..2681095) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2681115..2681121 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2681135..2681154 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2681150 /Source="Nicolas_upshifts" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2681202..2681744 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor for gbsAB" /protein_id="NP_390985.1" /db_xref="EnsemblGenomes-Gn:BSU31070" /db_xref="EnsemblGenomes-Tr:CAB15085" /db_xref="GOA:P71015" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12342" /db_xref="UniProtKB/Swiss-Prot:P71015" /translation="MDENPEFAAIEQARDLVIDSIAETMDLYGITRSVGILYGTMYMR DEMTLDEMREELQMSKPSMSTGVKKLQDLNVVKKTFHRGIRKHTFVAEKDFFKFFTNF FPPKWEREVQVNVTAIEEAQADLQKVLCKEDLDEDIKNEALQLYDQLESSKAYYDWLK RLAESVQTGEIFKFIPVETK*" /label="gbsR CDS" gene 2681202..2681744 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /label="gbsR gene" downshifts 2681727 /Source="Nicolas_upshifts" /id="D1603" /incds=0 /nref=74 /ntot=220 /MaxReadThrough="1.70461" /MaxDrop="3.5918" /score="26.1509691" /energy="-9.9" /TU="NA" /idTUdmin="U2409" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2681821..2681828 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2681841..2681941 /Source="Nicolas_S_feature" /locus_tag="new_3187402_3187502" /HighExp="BT, S0, BI, T-1.10H, T-1.40H, T1.0H, T-0.40H, T0.0H, S2, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1185" upshifts 2681841 /Source="Nicolas_upshifts" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2681843..2681862 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2681942..2682487 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /function="15.3: Cell adhesion" /experiment="publication(s) with functional evidences, PMID:21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732; Product type s: structure" /codon_start=1 /transl_table=11 /product="biofilm hydrophobic layer component" /protein_id="NP_390986.1" /db_xref="EnsemblGenomes-Gn:BSU31080" /db_xref="EnsemblGenomes-Tr:CAB15086" /db_xref="GOA:P71014" /db_xref="InterPro:IPR034650" /db_xref="PDB:4BHU" /db_xref="SubtiList:BG12341" /db_xref="UniProtKB/Swiss-Prot:P71014" /translation="MKRKLLSSLAISALSLGLLVSAPTASFAAESTSTKAHTESTMRT QSTASLFATITGASKTEWSFSDIELTYRPNTLLSLGVMEFTLPSGFTANTKDTLNGNA LRTTQILNNGKTVRVPLALDLLGAGEFKLKLNNKTLPAAGTYTFRAENKSLSIGNKFY AEASIDVAKRSTPPTQPCGCN*" /label="bslA CDS" gene 2681942..2682487 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /label="bslA gene" downshifts 2682474 /Source="Nicolas_upshifts" /id="D1604" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="0.85027" /MaxDrop="6.00835" /score="20.8976757" /energy="-10.2" /TU="NA" /idTUdmin="U2410" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2682579..2682586 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2682600..2682619 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2682607 /Source="Nicolas_upshifts" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2682612..2682780 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /product="cyclic-di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751; Product type n: RNA" /label="swdA RNA" gene 2682612..2682780 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /label="swdA gene" downshifts 2682761 /Source="Nicolas_upshifts" /id="D1605" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="6.04086" /MaxDrop="4.75274" /score="3.29445061" /energy="-6.1" /TU="U2411" /idTUdmin="U2410" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 2682853..2683521 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 23598340, 23671116, 25957408, 26771197" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 23598340, 23671116, 25957408, 26771197; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_390987.1" /db_xref="EnsemblGenomes-Gn:BSU31090" /db_xref="EnsemblGenomes-Tr:CAB15087" /db_xref="GOA:O32080" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="PDB:1LSU" /db_xref="PDB:2HMS" /db_xref="PDB:2HMT" /db_xref="PDB:2HMU" /db_xref="PDB:2HMV" /db_xref="PDB:2HMW" /db_xref="PDB:4J7C" /db_xref="PDB:4J90" /db_xref="PDB:4J91" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13943" /db_xref="UniProtKB/Swiss-Prot:O32080" /translation="MGRIKNKQFAVIGLGRFGGSICKELHRMGHEVLAVDINEEKVNA YASYATHAVIANATEENELLSLGIRNFEYVIVAIGANIQASTLTTLLLKELDIPNIWV KAQNYYHHKVLEKIGADRIIHPEKDMGVKIAQSLSDENVLNYIDLSDEYSIVELLATR KLDSKSIIDLNVRAKYGCTILAIKHHGDICLSPAPEDIIREQDCLVIMGHKKDIKRFE NEGM*" /label="ktrA CDS" gene 2682853..2683521 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /label="ktrA gene" CDS 2683528..2684865 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium transporter ATPase" /protein_id="NP_390988.1" /db_xref="EnsemblGenomes-Gn:BSU31100" /db_xref="EnsemblGenomes-Tr:CAB15088" /db_xref="GOA:O32081" /db_xref="InterPro:IPR003445" /db_xref="InterPro:IPR004772" /db_xref="PDB:4J7C" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13956" /db_xref="UniProtKB/Swiss-Prot:O32081" /translation="MTLQKDKVIKWVRFTPPQVLAIGFFLTIIIGAVLLMLPISTTKP LSWIDALFTAASATTVTGLAVVDTGTQFTVFGQTVIMGLIQIGGLGFMTFAVLIVMIL GKKIGLKERMLVQEALNQPTIGGVIGLVKVLFLFSISIELIAALILSIRLVPQYGWSS GLFASLFHAISAFNNAGFSLWPDNLMSYVGDPTVNLVITFLFITGGIGFTVLFDVMKN RRFKTFSLHTKLMLTGTLMLNAIAMLTVFILEYSNPGTLGHLHIVDKLWASYFQAVTP RTAGFNSLDFGSMREGTIVFTLLLMFIGAGSASTASGIKLTTFIVILTSVIAYLRGKK ETVIFRRSIKYPIIIKALAVSVTSLFIVFLGIFALTITEQAPFLQIVFETFSAFGTVG LTMGLTPELTTAGKCIIIVIMFIGRIGPLTFVFSFAKTEQSNIRYPDGEVFTG*" /label="ktrB CDS" gene 2683528..2684865 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /label="ktrB gene" downshifts 2684851 /Source="Nicolas_upshifts" /id="D1606" /incds=0 /nref=9 /ntot=98 /MaxReadThrough="0.86883" /MaxDrop="3.37604" /score="25.8974852" /energy="-11.9" /TU="NA" /idTUdmin="U2411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2684901..2685164) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390989.1" /db_xref="EnsemblGenomes-Gn:BSU31110" /db_xref="EnsemblGenomes-Tr:CAB15089" /db_xref="GOA:O32082" /db_xref="InterPro:IPR008024" /db_xref="SubtiList:BG13955" /db_xref="UniProtKB/Swiss-Prot:O32082" /translation="MQKYRRRNTVAFTVLAYFTFFAGVFLFSIGLYNADNLELNEKGY YIAVMILVAVGAILTQKVTRDNAEDNEIIAEQEKRQNQSHIES*" /label="yubF CDS" gene complement(2684901..2685164) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /label="yubF gene" downshifts complement(2684919) /Source="Nicolas_upshifts" /id="D1607" /incds=0 /nref=237 /ntot=309 /MaxReadThrough="2.4577" /MaxDrop="7.13564" /score="30.2020977" /energy="-11.9" /TU="NA" /idTUdmin="U2412" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2685204..2685223) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2685206) /Source="Nicolas_upshifts" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2685236..2685243) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2685273..2686121) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /EC_number="3.2.1.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12525152, 16855244, 28448118, 28811162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12525152, 16855244, 28448118, 28811162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exoglucosaminidase" /protein_id="NP_390990.1" /db_xref="EnsemblGenomes-Gn:BSU31120" /db_xref="EnsemblGenomes-Tr:CAB15090" /db_xref="GOA:O32083" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR025987" /db_xref="SubtiList:BG13954" /db_xref="UniProtKB/Swiss-Prot:O32083" /translation="MARKKLKKRKLLISLFFLVSIPLALFVLATTLSKPIEISKETEE IDEQQVFIDSLSGHAQILYEKYHVLPSITIAQAILESDWGNSELAAKANNLFGVKGNY KGHHVTMETDEVEKGKRKTIRAKFRKYSTFFESMDDHAQLFVRGTSWNKKKYKPVLEA GNYKEAATALQTSGYATDPDYADKISAIVEKYDLDEYDEVNPSLKSVDLNASIKDSAV QDVWSKPSTDDRSIRLTSAQSYVGKDIKVVSKKQKGQSVWYQFQINDKLIGWIDDSAV EIKEAT*" /label="lytG CDS" gene complement(2685273..2686121) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /label="lytG gene" promotor_-10 complement(2686166..2686185) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2686176) /Source="Nicolas_upshifts" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2686200..2686207) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2686282..2687817) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28248504; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390991.1" /db_xref="EnsemblGenomes-Gn:BSU31130" /db_xref="EnsemblGenomes-Tr:CAB15091" /db_xref="GOA:O32084" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13953" /db_xref="UniProtKB/Swiss-Prot:O32084" /translation="MKTKHYWVISLLAVLAVGPGLMSNTALSSVQGLVQKTVGTSVFT SVNPILIGNMAFALLVPAGPLLRKKFGARPVYLASLPVFILGSLLIACSGDIALMAAG RFLQGAATGVMLMIMIPMLVLSFPIERRNYALLVLIGGFYGSVIIGTILGTIATSCGH WRWLFFIFGTLSLIGVAVSYFFLHDEHHGAADQEQPLDRAGILLSVFLAAASAVSFIF LQKWGLSSGYVWIGFGVTLCLLIGLLIVEYKVKNPFISIKLMLLPKPVLGLLIIAAGT ITVAVSLSAFQGLLRQMYDISQEHLILLSLTLLIGVAIAAILSALLYDKVGPGMLGII GGLILVFVNFQWLHIQDRSSLYMFAALFIMLAAGTGLTVAAGLMGAAMGGPLPDLVKR MTAVQFLRLFVYMGVPILIGFFTKKDAARQSGSVQDSMMTAYHDLFFISFILSVLLVC LSFCMNATGMGHKLAHKPHDKAKTAPEKPAVSAQGLSKATVKSYKVINDTEYRNALRN LQK*" /label="yubD CDS" gene complement(2686282..2687817) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /label="yubD gene" downshifts complement(2686291) /Source="Nicolas_upshifts" /id="D1608" /incds=0 /nref=45 /ntot=159 /MaxReadThrough="1.39941" /MaxDrop="4.26166" /score="-3.3162201" /energy="-5.7" /TU="NA" /idTUdmin="U2415" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 2687475..2687575 /Source="Nicolas_upshift_promotors" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2687535 /Source="Nicolas_upshifts" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2687601 /Source="Nicolas_upshifts" /id="D1609" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="0.0870599999999992" /MaxDrop="3.19459" /score="-1.6836786" /energy="-10.4" /TU="NA" /idTUdmin="U2416" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature complement(2687818..2687985) /Source="Nicolas_S_feature" /locus_tag="new_3193379_3193546_c" /HighExp="Cold, S8, G180, UNK1, C30, G135, S7, Lbexp, MG 25, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34877900000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1186" promotor_-10 complement(2687974..2687993) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2687985) /Source="Nicolas_upshifts" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2687987..2688864) /Source="Nicolas_S_feature" /locus_tag="new_3193548_3194425_c" /HighExp="G180, Cold, C30, G135, Paraq, Oxctl, S8, G150, H2O2, Heat" /AntisenseName="cdoA" /AntisenseCor="-2.3104546834536201E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1187" promotor_-35 complement(2688008..2688015) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2688227..2688236 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2688250..2688269 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2688250 /Source="Nicolas_upshifts" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="upshifts" CDS 2688302..2688787 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /EC_number="1.13.11.20" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10939241, 15699190, 16855246, 25307852, 26590284" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15699190, 16855246, 25307852, 26590284; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine dioxygenase" /protein_id="NP_390992.1" /db_xref="EnsemblGenomes-Gn:BSU31140" /db_xref="EnsemblGenomes-Tr:CAB15092" /db_xref="GOA:O32085" /db_xref="InterPro:IPR010300" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:3EQE" /db_xref="PDB:4QM8" /db_xref="PDB:4QM9" /db_xref="SubtiList:BG13952" /db_xref="UniProtKB/Swiss-Prot:O32085" /translation="MELYECIQDIFGGLKNPSVKDLATSLKQIPNAAKLSQPYIKEPD QYAYGRNAIYRNNELEIIVINIPPNKETTVHDHGQSIGCAMVLEGKLLNSIYRSTGEH AELSNSYFVHEGECLISTKGLIHKMSNPTSERMVSLHVYSPPLEDMTVFEEQKEVLEN S*" /label="cdoA CDS" gene 2688302..2688787 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /label="cdoA gene" S_feature 2688788..2689074 /Source="Nicolas_S_feature" /locus_tag="new_3194349_3194635" /HighExp="S6, S8, S7, BT, S5, G/S, C30, Pyr, C90, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.53171800000000002" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1188" tRNA complement(2688894..2688966) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala (GGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Ala1 tRNA" gene complement(2688894..2688966) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /label="trnSL-Ala1 gene" downshifts complement(2688909) /Source="Nicolas_upshifts" /id="D1610" /incds=0 /nref=37 /ntot=180 /MaxReadThrough="3.88031" /MaxDrop="4.38957" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2688953) /Source="Nicolas_upshifts" /id="D1611" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.34085" /MaxDrop="4.19639" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2688977..2688996) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2688997) /Source="Nicolas_upshifts" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2689011..2689014) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2689031 /Source="Nicolas_upshifts" /id="D1612" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.04964" /MaxDrop="3.22361" /score="-1.6836786" /energy="-10.4" /TU="U2416" /idTUdmin="U2416" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2689074..2689904) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /EC_number="3.6.1.27" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15138271, 15849754, 16850406, 27528508, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15138271, 15849754, 16850406, 27528508, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl-pyrophosphate phosphatase" /protein_id="NP_390993.1" /db_xref="EnsemblGenomes-Gn:BSU31150" /db_xref="EnsemblGenomes-Tr:CAB15093" /db_xref="GOA:P94507" /db_xref="InterPro:IPR003824" /db_xref="SubtiList:BG13951" /db_xref="UniProtKB/Swiss-Prot:P94507" /translation="MTLWELFVAAILGIVEGLTEYAPVSSTGHMIIVDDIWLKSSNLM SEEAANSFKVVIQLGSILAVAIVFKDRILNLLGLKKNITSDQEQGHKLSIAQIAVGLV PAAVLGFLFEDYIDEYLFSVKTVAIGLIAGAILMLFADWVNKRKTATDTLDRISYKQA IAVGLFQCLSLWPGFSRSGSTISGGVILGLNHRAAADFTFIMAMPIMMGASFLSLVKH WDSLSSDLMPFFIVGFICAFVVALFVVRFFLRLINKIKLVPFAIYRIILGVILLLIMM *" /label="uppP CDS" gene complement(2689074..2689904) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /label="uppP gene" downshifts complement(2689085) /Source="Nicolas_upshifts" /id="D1613" /incds=0 /nref=60 /ntot=208 /MaxReadThrough="3.0552" /MaxDrop="5.61932" /score="-4.25033697" /energy="-6.7" /TU="U2419" /idTUdmin="U2419" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2689905..2689996) /Source="Nicolas_S_feature" /locus_tag="new_3195466_3195557_c" /HighExp="dia15, H2O2, Salt, Etha, dia5, LBGtran, M0t90, Lbstat, Mt0, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1189" CDS complement(2689997..2691163) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16385049, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390994.1" /db_xref="EnsemblGenomes-Gn:BSU31160" /db_xref="EnsemblGenomes-Tr:CAB15094" /db_xref="GOA:O32086" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13950" /db_xref="UniProtKB/Swiss-Prot:O32086" /translation="METLQTWSGRFKRFFLDNKFVLFLLVLLLIGLNILVFTKTSFIF TPIIVLLKTISLPIILTGIVFYLLNPVVDFLERRRIRRIYSILLLYLLVIGLITITIV SIIPFLKEQIMSLIDNIPRYVDVVENQTKQLIGSNFVNQAQQTMNINISDLATKVSDQ AATIVNSTFTGVGNFIGALTEIIISIVTVPFILFYLLKDGRKLPVYILKFVPTRLKEQ TYTVLSEMNHRLSSYIRGQIIVSFCIGFLLFIGYLIIGLDYASLLAVIAACTSIVPYL GPTIAITPAIIIAIVTSPLMLLKLVIVWTIVQLIEGKLISPQIMGKNLHIHPITIIFL LLTAGKLFGVVGIILAIPGYAVAKVITTHLFDWFKMQSHLYDEEKNENTPGHKV*" /label="yubA CDS" gene complement(2689997..2691163) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /label="yubA gene" promotor_-35 2691159..2691163 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2691171..2691185 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2691187..2691206) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2691187 /Source="Nicolas_upshifts" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2691206) /Source="Nicolas_upshifts" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2691220..2691227) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2691285..2691292 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2691298 /Source="Nicolas_upshifts" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2691303..2691322 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2691345..2692331 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /EC_number="1.1.1.371" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12450853, 28043209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450853, 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol dehydrogenase (NADP+-dependent);biofilm formation" /protein_id="NP_390995.1" /db_xref="EnsemblGenomes-Gn:BSU31170" /db_xref="EnsemblGenomes-Tr:CAB15095" /db_xref="GOA:O05265" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12388" /db_xref="UniProtKB/Swiss-Prot:O05265" /translation="MIRFAIIGTNWITDRFLESAADIEDFQLTAVYSRSAERAGEFAA KHNAAHAFSDLQEMAASDCFDAVYIASPNALHKEQAVLFMNHGKHVLCEKPFASNTKE TEEMISAAKANGVVLMEAMKTTFLPNFKELKKHLHKIGTVRRFTASYCQYSSRYDAFR SGTVLNAFQPELSNGSLMDIGVYCIYPAVVLFGAPKDVKANGYALSSGVDGEGTVILS YDGFEAVLMHSKISTSYAPAEIQGEDGTIVIDTIHRPERVEIRYRDGRLENIAIPDPK PAMFYEAEEFVTLIKENKLESEENTFERSLTTAKIMEEARKQMGIVYPADQA*" /label="iolU CDS" gene 2691345..2692331 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /label="iolU gene" downshifts 2692302 /Source="Nicolas_upshifts" /id="D1614" /incds=0 /nref=30 /ntot=279 /MaxReadThrough="1.83109" /MaxDrop="4.96985" /score="21.8997198" /energy="-15.1" /TU="NA" /idTUdmin="U2420" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2692372..2693646) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /EC_number="5.3.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960106, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960106, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose isomerase" /protein_id="NP_390996.1" /db_xref="EnsemblGenomes-Gn:BSU31180" /db_xref="EnsemblGenomes-Tr:CAB15096" /db_xref="GOA:O05264" /db_xref="InterPro:IPR009308" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG12387" /db_xref="UniProtKB/Swiss-Prot:O05264" /translation="MTIKANYDSAKQAYEKWGIDVEEALRQLEQVPISIHCWQGDDIE GFEVNKGELSGGIDVTGNYPGKAQTPEELRRDLEKALSLIPGKHRVNLHAIYAETNRE AVERDELKPQHFENWVKWAKNLGLGLDFNPTLFSHEKAADGLTLSHPDPDIREFWIRH CIACRRIGEYFGKELGTPCLTNIWIPDGYKDIPSDRLTPRKRLKESLDRIFSEEISEQ HNLDSIESKLFGLGSESYVVGSHEFYLAYALTNHKLCLLDTGHFHPTETVSNKISSML LYTDKLALHVSRPVRWDSDHVVVLDDELREIALEIVRNHALEKVAIGLDFFDASINRV AAWTIGTRNMIKALLYALLLPNGYLKQLQEEGRYTERLALMEEFKTYPFGAIWDSYCE QMGVPVKEAWLYDIKEYEQQVLLKRKASSPIV*" /label="rhaA CDS" gene complement(2692372..2693646) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /label="rhaA gene" downshifts complement(2692385) /Source="Nicolas_upshifts" /id="D1615" /incds=0 /nref=3 /ntot=29 /MaxReadThrough="0.802" /MaxDrop="4.45322" /score="14.0829844" /energy="-12.6" /TU="NA" /idTUdmin="U2421" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2693672..2693986) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /EC_number="5.1.3.32" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15576793, 15876375, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576793, 15876375, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose mutarotase" /protein_id="NP_390997.1" /db_xref="EnsemblGenomes-Gn:BSU31190" /db_xref="EnsemblGenomes-Tr:CAB15097" /db_xref="GOA:O05263" /db_xref="InterPro:IPR008000" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR013448" /db_xref="SubtiList:BG12386" /db_xref="UniProtKB/Swiss-Prot:O05263" /translation="MKRKASIMFVHQDKYEEYKQRHDDIWPEMAEALKAHGAHHYSIF LDEETGRLFAYLEIEDEEKWRKMADTEVCQRWWKSMAPLMKTNSDFSPVAIDLKEVFY LD*" /label="rhaM CDS" gene complement(2693672..2693986) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /label="rhaM gene" CDS complement(2694004..2695461) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /EC_number="2.7.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16674975, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16674975, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnulokinase" /protein_id="NP_390998.1" /db_xref="EnsemblGenomes-Gn:BSU31200" /db_xref="EnsemblGenomes-Tr:CAB15098" /db_xref="GOA:O05262" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR013449" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG12385" /db_xref="UniProtKB/Swiss-Prot:O05262" /translation="MIYTAIDVGASSGRIMVGELNEGKLDIQEIHRFANGFSQRDGHC LWDIDHLLKQILQGLQKVKTLGYEHCTVGIDTWAVDYVLLDEKGDRLREAISYRDRRT DHTIDKLEHTLSKAAIYQKTGIQFQPFNTIYQLFEEDRELLKKTDKIMMIPDYLGYCL TGKAVTEITNVSTTQLLNVSTGNLDPELLEAVSVLEQQFAPLTEPGCELGKLRNEWFP DYDLPACKVMTVATHDTASAVIAAPGVNDGWAYISSGTWSLIGVENKTPIITDLALEN NYTNERGANNTIRFLKNIIGMWVIQEVKQQLQADYSFQQLAEEAKKTEPFQQFINLND KRFLNPENMIKEIQHYCRQTRQKIPRTAGELACCIYSNLAIIYAIAIKELETITEKPI EQFHIIGGGARNDFLNQLTADMSGKAVYAGPIEATATGNLLMQMIAAKEVKDIKEARQ VVRNSFPIKVFTPKDIDRSTIIQSFQQTVLKALSK*" /label="rhaB CDS" gene complement(2694004..2695461) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /label="rhaB gene" CDS complement(2695466..2696242) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11496004, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11496004, 26712933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the rhamnose operon(RhaR / l-rhamnulose-1-phosphate)" /protein_id="NP_390999.1" /db_xref="EnsemblGenomes-Gn:BSU31210" /db_xref="EnsemblGenomes-Tr:CAB15099" /db_xref="GOA:O05261" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12384" /db_xref="UniProtKB/Swiss-Prot:O05261" /translation="MLVAERQQKIVEIVNMRSSIRVSELSDIFSVTEETIRRDLEKLE KEHKLSRSHGGAVSIQQKESEIHFSEREITNVIEKKAIAHEAAKYVKSGDRIILDAST TAWYMAKILPDIELTVITNSMKAAIELSNKENISVISTGGILLEKSLSFAGPLAERSL ETYHVNKTFLSCKGFDVHNGMSDSNEWQALLKKRMIERSDQTILMADSSKWGNREFSH IASLQDVSRLITDSGLDPASVKALEDKKVKVTAVPLSKRG*" /label="rhaR CDS" gene complement(2695466..2696242) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /label="rhaR gene" misc_feature complement(2696276..2696295) /Source="Nicolas_upshift_promotors" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2696292) /Source="Nicolas_upshifts" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2696299..2698368) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /EC_number="1.1.1.-" /EC_number="4.1.2.19" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24391637, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24391637, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional rhamnulose-1-phosphate aldolase/alcohol dehydrogenase" /protein_id="NP_391000.1" /db_xref="EnsemblGenomes-Gn:BSU31220" /db_xref="EnsemblGenomes-Tr:CAB15100" /db_xref="GOA:P40747" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR013454" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG10947" /db_xref="UniProtKB/Swiss-Prot:P40747" /translation="MVKHIWDSERAAQLPKGVEELVYRSNLIGSDRTVCNWGGGNTSM KTTEKDFRGREIEVMWVKGSGSDLATMKAHNFSGLKLDDIRPLIKRDQMPDEEMVDYL SHCMIDSKHPRPSIETLLHAFLPYKHVDHTHPDAIISICCADNGKQIAEDIYGNRFVW VPYVRPGFTLSKMIAEGVANNPHAELVLMEKHGLVTWGETSETCYQKTISIIQEAEQY INDRINQHEVFGGKRYQPLPEDKRKQILAGIMPVIRGAVSEEKKMILSYDDHDDVLEF VNSVQAPALSQIGAACPDHLVHTKRVPLYIDWNPETQDVHKLADLIKSGVETFTSEYQ AYFTRNQQDGDQIFESAPRVILIPGIGMVNTGKSYAMSKVSGALYRRAIAVMKGATAL GQFVSLHENESYHVEYWPLELYKLTLAPPEAEFSRKVALITGGAGGIGSAACRRFAAE GGHVIVADLNIEGAQKIAGEINDAYGKGRAMAVKMDVTKEEDVQSAFERAALAYGGID IVVNNAGLATSSPFDETSLKEWNLNMNVLGTGYFLVAREAFKQMKHQNRGGSMVFVGS KNSVYAGKNASAYSSVKALETHLARCIAAEGGEFGIRVNSVLPDAVLQGSAIWGSSWR EERAAAYGIEPDQLEEHYRKRTALLVNIYPEDIAEAIAFFASSKAEKTTGCMITVDGG VPAAFTR*" /label="rhaE CDS" gene complement(2696299..2698368) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /label="rhaE gene" promotor_-10 complement(2698401..2698420) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2698413) /Source="Nicolas_upshifts" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2698434..2698440) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2698506..2700494) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391001.1" /db_xref="EnsemblGenomes-Gn:BSU31230" /db_xref="EnsemblGenomes-Tr:CAB15101" /db_xref="GOA:P39217" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10862" /db_xref="UniProtKB/Swiss-Prot:P39217" /translation="MGKFIQWIKQPSISKPLIAAFLAVLILPVGVLAYFSYQSAWNAL DRELISSAKGNVEELNSTLQNKLEDKVKAIDYYSETVDKDILLGKNKTLLKEKFKQYT TLNDDVGAIYAASEDKKLYKYPDSGVPKGFDPTGRDWYKQAVAEKGQAVFSEPYTDEA TGDIVVTISKQLKDGSGVIALDLNLDEVLTASKRIKIGKEGFAFITTGNKKYIAHPTI KPGTTGSGDWTNQVYSKKEGSFEYTFEGKEKKMAFTTNKLTGWKIAGTYFVSELQDAS SPVLNTAVIILCVSIVIGGILILYIIRAITKPLRKLVSTSAKISSGDLTEVIDIHSKN EFGQLGESFNEMSASLRSVIGVIQTSVENVASSSEELTASAAQTSKATEHITLAIEQF SDGNEAQSEKLETSSNHLSQMNEGISKVAQASSTITKSSIQSSEAAGSGEKLVEHTVG QMKTIDQSVQKAEAVVKGLETKSQDITSILNVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIQEIVREISTSLSMFQSVNHEVKEGLQITDQ TAESFKQIYEMTTQISGELQNLNATVEQLSAGSQEVSSAVEDISAVAKESSAGIQDIA ASAEEQLASMEEISSSAETLANMAEELQDITKKFKIES*" /label="tlpB CDS" gene complement(2698506..2700494) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /label="tlpB gene" downshifts complement(2698525) /Source="Nicolas_upshifts" /id="D1616" /incds=0 /nref=108 /ntot=174 /MaxReadThrough="3.32915" /MaxDrop="6.75141" /score="18.7221191" /energy="-8.3" /TU="NA" /idTUdmin="U2423" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2700498..2700505 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2700515..2700533) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2700521..2700540 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2700528) /Source="Nicolas_upshifts" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="upshifts" upshifts 2700537 /Source="Nicolas_upshifts" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2700547..2700554) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2700603 /Source="Nicolas_upshifts" /id="D1617" /incds=0 /nref=4 /ntot=11 /MaxReadThrough="1.04089" /MaxDrop="4.2056" /score="13.4355481" /energy="-10.7" /TU="NA" /idTUdmin="U2424" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(2700608..2702593) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 9721285, 12011078" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 9721285, 12011078; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391002.2" /db_xref="EnsemblGenomes-Gn:BSU31240" /db_xref="EnsemblGenomes-Tr:CAB15102" /db_xref="GOA:P39214" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10861" /db_xref="UniProtKB/Swiss-Prot:P39214" /translation="MKKILQLIKQRSITRKLLVSFLSILIIPVVILAIFAYQSASSSL DRQMMGSALENVQQLNEIINTSIGEKENSADYFSEWLTKEKYNAKSNASIAEKFSQYI SINKDVESIYTSDTKGHFTRYPDLPMPSGYNPVERDWYKKAVANKGKVVITDPYKTAS TNTMVVTIAQQTKDGSGVIAINMTIENLLKTTKKVNIGTQGYAFIMTKDKKVVAHPNE QSGTELKGDWLDKMLSADKGDFQYTMDGDKKKMAFDTNKLTGWKIGGTMYLDEIHEAA QPVLHLALIVLAAAIIIGIIVMTLIIRSITTPLKQLVGSSKRISEGDLTETIDIRSKD ELGELGKSFNNMASSLRSLIHAIQDSVDNVAASSEELTASAAQTSKATEHITLAIEQF SNGNEKQNENIETAAEHIYQMNDGLTNMAQASEVITDSSVQSTEIASEGGKLVHQTVG QMNVIDKSVKEAEQVVRGLETKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIIEIVKEINTSLGMFQSVNQEVQTGLDITDK TEMSFKRISEMTNQIAGELQNMSATVQQLSASSEEVSGASEHIASISKESSAHIQDIA ASAEEQLASMEEISSSAETLSSMAEELRDMTKRFKIE*" /label="mcpA CDS" gene complement(2700608..2702593) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /label="mcpA gene" downshifts complement(2700613) /Source="Nicolas_upshifts" /id="D1618" /incds=0 /nref=196 /ntot=232 /MaxReadThrough="3.11319" /MaxDrop="7.54297" /score="40.6270404" /energy="-13.6" /TU="U2425" /idTUdmin="U2425" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2702614..2702632) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2702629) /Source="Nicolas_upshifts" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2702631..2702718) /Source="Nicolas_S_feature" /locus_tag="new_3208192_3208279_c" /HighExp="GM 150, T0.0H, T-1.40H, T-0.40H, MG 150, T-5.40H, T-3.40H, T-1.10H, T-2.40H, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1190" promotor_-35 complement(2702646..2702653) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2702719..2704707) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871, 26522943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871, 26522943; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (membrane curvature dependent localisation)" /protein_id="NP_391003.1" /db_xref="EnsemblGenomes-Gn:BSU31250" /db_xref="EnsemblGenomes-Tr:CAB15103" /db_xref="GOA:P39216" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10860" /db_xref="UniProtKB/Swiss-Prot:P39216" /translation="MKKTLTTIRRSSIARRLIISFLLILIVPITALSVSAYQSAVASL DVQMTQSAKENVQILDHIIDDKISTTEKSLAYFSDWATAEKFQDKKKTELKQEFKQFI QMNDNVAAVFSSGKDGDFTRYPYADMPSDFNALERDWYKEAMANKGKTIVTEPYESIS SGKMVVTIARQTVDGSGVVAIDMKIDDLVTTAKGINIGKEGYAFILSQNKKVIAYSGE KAGTELKGDWVDKLYKDKSGDFEYTYKGKKKKMAFATSQTTGWKISGTMYANEIHDAA SRVLIMASIVLAIAIGAGMTAIYFVIRSITKPLRRIVASAEKISEGDLTETIEINSKD ELGVLSESFNHMAHSLRSLIHGIKDSVEHVASSSEELTASADQTSRATEHITMAIEQF SNGSESQSEKIETTTEQINEMNDGLAELARAAAVITETSADSTEVSSKGETLVQKTAG QMNTIDHSVKAAEQVVKGLEIKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIESLISEIVKEIHTSLNVLQSVNKEVETGLVMTDE TKQSFKHISQMTNQIASELQNMNATVEELSAGAQEISAASNDITAISKESSDGIQDIA ASAEEQLASMEEISSSALTLERMSEELRDLTKQFKVDK*" /label="tlpA CDS" gene complement(2702719..2704707) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /label="tlpA gene" promotor_-10 complement(2704732..2704750) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-10" upshifts complement(2704747) /Source="Nicolas_upshifts" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="upshifts" promotor_-35 complement(2704764..2704771) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-35" CDS complement(2704884..2706872) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391004.2" /db_xref="EnsemblGenomes-Gn:BSU31260" /db_xref="EnsemblGenomes-Tr:CAB15104" /db_xref="GOA:P39215" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10859" /db_xref="UniProtKB/Swiss-Prot:P39215" /translation="MKTFINWLKKPSISKKLIVSFIAILIIPILILEFSSYRSASGKL DQEIMGNAKNSVDTFNTTVTNDLGEKAKAVTFFSESLKRSAFKGKSNQEEIKAKFSQY VSINQGVARIYGGADNGTYVQAPKEKLPEGYDPRQRPWYQDAMKAGGEIVVTDPYVAA SDGSMVITIAQELKDGSGVVAMDITIDKLLEQMKQIKVGKEGYAFIATKNKTYVAHKN HKAGEKLSGDWVAKMYANDSGELQYTLNNEDKKMTYTTNELTGWKIAGTMYMDEIKDA SKSVLTTGMIVLIASIVAGGILILFIVRSITKPLKRLVQSSKTISRGDLTETIEIHSK DELGELGESFNEMGQSLRSLISAIQDSVNNVAASSEQLTASAGQTSKATEHITMAIEQ FSNGNEEQSEKVESSSHQLNLMNEGLQQVSQTSSDITKASIQSTEIAGTGEKFVQQTV GQMNSINQSVQQAEAVVKGLEGKSKDITSILRVINGIADQTNLLALNAAIEAARAGES GRGFSVVAEEVRKLAVQSADSAKEIEKLIQEIVAEIDTSLHMFKEVNQEVQSGLVVTD NTKESFQSIFSMTNEIAGKLQTMNSTVEQLSDRSQHVSAAVSGIADVSKESSASIQDI AASAEEQLASMEEISSSATTLAQMAEELRDLTKQFKIE*" /label="mcpB CDS" gene complement(2704884..2706872) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /label="mcpB gene" downshifts complement(2704903) /Source="Nicolas_upshifts" /id="D1619" /incds=0 /nref=136 /ntot=224 /MaxReadThrough="3.76161" /MaxDrop="7.09773" /score="30.8363643" /energy="-10.7" /TU="U2427" /idTUdmin="U2427" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2706893..2706911) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2706914) /Source="Nicolas_upshifts" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2706924..2706931) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2706974..2706983 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2706997..2707016 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2707000 /Source="Nicolas_upshifts" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="upshifts" CDS 2707030..2707767 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /EC_number="2.3.2.13" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9692191, 16267299, 16751597, 16936016, 18249137, 26322858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9692191, 16267299, 16751597, 16936016, 18249137, 26322858; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein-glutamine gamma-glutamyltransferase (transglutaminase)" /protein_id="NP_391005.1" /db_xref="EnsemblGenomes-Gn:BSU31270" /db_xref="EnsemblGenomes-Tr:CAB15105" /db_xref="GOA:P40746" /db_xref="InterPro:IPR020916" /db_xref="PDB:4P8I" /db_xref="PDB:4PA5" /db_xref="SubtiList:BG10946" /db_xref="UniProtKB/Swiss-Prot:P40746" /translation="MIIVSGQLLRPQDIENWQIDQDLNPLLKEMIETPVQFDYHSIAE LMFELKLRMNIVAAAKTLHKSGAKFATFLKTYGNTTYWRVSPEGALELKYRMPPSKAI RDIAENGPFYAFECATAIVIIYYLALIDTIGEDKFNASFDRIILYDWHYEKLPIYTET GHHFFLGDCLYFKNPEFDPQKAQWRGENVILLGEDKYFAHGLGILNGKQIIDKLNSFR KKGALQSAYLLSQATRLDVPSLFRIVR*" /label="tgl CDS" gene 2707030..2707767 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /label="tgl gene" promotor_-10 complement(2707055..2707074) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-10" upshifts complement(2707063) /Source="Nicolas_upshifts" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="upshifts" promotor_-35 complement(2707090..2707094) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-35" S_feature 2707768..2710588 /Source="Nicolas_S_feature" /locus_tag="new_3213329_3216149" /HighExp="S6, S8, S7, BT, S5, C30, B36, Pyr, BC, C90" /AntisenseName="yugT" /AntisenseCor="0.63350809138227804" /AntisenseRegPval="-30.9" /CDS_PredictionProba="0.61985900000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1191" CDS complement(2707781..2708035) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097776.1" /db_xref="EnsemblGenomes-Gn:BSU31279" /db_xref="EnsemblGenomes-Tr:CAX52682" /db_xref="UniProtKB/Swiss-Prot:C0H3Q3" /translation="MNILQYSYKKRGKIEFVFEGWPHSKVTMVPIKGYYFVRFIKWSS QDPIVTRNDLEKMEWAANQYFGTAPFYRKRKAFETPSSGK*" /label="yuzH CDS" gene complement(2707781..2708035) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /label="yuzH gene" downshifts complement(2707807) /Source="Nicolas_upshifts" /id="D1620" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="2.39206" /MaxDrop="2.92958" /score="-2.51333596" /energy="-14.7" /TU="NA" /idTUdmin="U2430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2708036..2708292) /Source="Nicolas_S_feature" /locus_tag="new_3213597_3213853_c" /HighExp="Etha, Sw, Salt, Gly, BC, M9-stat, Lbstat, Heat, LPhT, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37980700000000001" /TUshortSig="SigB" /TUshortPSig="0.969" /TUlongSig="NA" /TUlongPSig="NA" /label="S1192" CDS complement(2708293..2708691) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391006.2" /db_xref="EnsemblGenomes-Gn:BSU31280" /db_xref="EnsemblGenomes-Tr:CAB15106" /db_xref="InterPro:IPR001602" /db_xref="InterPro:IPR035917" /db_xref="SubtiList:BG12373" /db_xref="UniProtKB/Swiss-Prot:O05243" /translation="MLKTLQIKTTKRDEMIDITREVEAFLQETGITSGAALIYCPHTT AGITINENADPDVKKDMLRRFDEVYPWEHELDRHMEGNTAAHMKSSTVGASQHVIVEN GRLILGTWQGIYFCEFDGPRTRTCYIKMMG*" /label="yugU CDS" gene complement(2708293..2708691) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /label="yugU gene" CDS complement(2708651..2708785) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514000.1" /translation="MFYRVYESGLTGKKRTQNELSDESGQTKGETNAENTANQNNQTR *" /label="hypothetical protein CDS" gene complement(2708651..2708785) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /label="gene" promotor_-10 complement(2708734..2708753) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2708741) /Source="Nicolas_upshifts" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2708768..2708774) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2708811..2710475) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1761534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-1,6-glucosidase" /protein_id="NP_391007.2" /db_xref="EnsemblGenomes-Gn:BSU31290" /db_xref="EnsemblGenomes-Tr:CAB15118" /db_xref="GOA:O05242" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG12372" /db_xref="UniProtKB/Swiss-Prot:O05242" /translation="MKKAWWKEAVVYQIYPRSFKDSNGDGIGDIQGIRTKLSYIKELG ADVIWICPLYDSPNADNGYDIRDYQNILSEFGTMEDFDELLGDIHDLDMKLIMDLVVN HTSDEHPWFIESRSSIHSEKRDWYIWKDGKNGKTPNNWESIFGGPAWEYDQKTSQYYL HLFDKKQPDLNWENEKVRNAVYDMINWWLDKGIDGFRVDAITHIKKKEGFPDMPNPKG LDYVPSFPYHMNADGIMDLLTELKENTFSRYPIMTVGEANGVAAKEAADWAGEKNGIF SMIFQFEHLGLWDVEINESIDIVAFKRILTDWQDSLEGIGWNALFMENHDQPRSVSVW GDDGVYLKESAKALSAVYFLMKGTPFIYQGQELGMTNVAFPSIEDYDDVALKRLYETK TAKGTSHEDVMKIVWKKGRDNSRTPMQWNAGPYAGFSEAKPWIGINENYKWLNAEAQK NDKTSVYHFYKSLIKLRQTYDVFINGTYELILPEDQQIFAYLRKNESHTALIAANLTG TPALFRHSGLPLSSDALVLSNIETEPHKHMTSVLLKPYEARIYLWC*" /label="yugT CDS" gene complement(2708811..2710475) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /label="yugT gene" downshifts complement(2708827) /Source="Nicolas_upshifts" /id="D1621" /incds=0 /nref=13 /ntot=38 /MaxReadThrough="1.79723" /MaxDrop="4.64379" /score="19.4176812" /energy="-6.5" /TU="NA" /idTUdmin="U2432" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2709783..2709802) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2709788) /Source="Nicolas_upshifts" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2709816..2709823) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2710500..2710518) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2710517) /Source="Nicolas_upshifts" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2710534..2710539) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2710602..2711891) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_391008.2" /db_xref="EnsemblGenomes-Gn:BSU31300" /db_xref="EnsemblGenomes-Tr:CAB15119" /db_xref="GOA:O05241" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12371" /db_xref="UniProtKB/Swiss-Prot:O05241" /translation="MLILQLIAIFVLIGITAVFVAAEFAIVKIRGSKINQLIESGDSR ALAAHKIISNLDEYLSACQLGITITALGLGWLGEPTFERFLHPLFTMTGIPEPFNHIV TFVVAFIIVTFLHVVMGELAPKTVSIQKAEAVSLWIAKPLIWFYKITYPFIKALNGSA SFLVKLFGFHSVKEHQVVISEEELRLILSESYEKGEINQSEFRYVNKIFEFDNRVARE IMIPRTEIAVISLEQSLEEAIHHIINERYTRYPVIKDDKDHILGIINSKDMFKAYFLG QPIKLNQIMRPVIRVIESIPVQQLLIRMQKERIHMAILVDEYGGTAGLVTVEDIIEEI VGEIRDEYDQDETPHILKKGEHHYVMDGKALIDEVNDLLDIAIENEEIDTIAGWLLTQ KMELKAGDVIHAEGCEFKILDAEDHHIRFVEIKKTDF*" /label="yugS CDS" gene complement(2710602..2711891) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /label="yugS gene" downshifts complement(2710611) /Source="Nicolas_upshifts" /id="D1622" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.89237" /MaxDrop="3.67001" /score="3.60520478" /energy="-7.6" /TU="NA" /idTUdmin="U2434" /TUdmin=13 /isTUend="TRUE" /label="downshifts" promotor_-35 2711420..2711426 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2711440..2711458 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2711446 /Source="Nicolas_upshifts" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="upshifts" S_feature 2711450..2712102 /Source="Nicolas_S_feature" /locus_tag="new_3217011_3217663" /HighExp="Etha, Sw, Gly, Salt, BC, B60, Heat, S8, B36, HiTm" /AntisenseName="yugS" /AntisenseCor="0.12310225183111501" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1193" CDS complement(2711935..2712612) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16704729, 16850406, 24383880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent protease/peptidase" /protein_id="NP_391009.1" /db_xref="EnsemblGenomes-Gn:BSU31310" /db_xref="EnsemblGenomes-Tr:CAB15120" /db_xref="GOA:O05248" /db_xref="InterPro:IPR007395" /db_xref="SubtiList:BG12370" /db_xref="UniProtKB/Swiss-Prot:O05248" /translation="MLFIFLTIAALGLSFWAQFKVKSNFEKYSKVEASSGRTGAETAR RILDINGLYDVPVEPVRGTLTDHYDPTRRVVRLSEPVYYGRSISAISVASHEVGHALQ HQESYGALVLRHKIFPVVNFASGVAPLLFLGGMLLGSLNLIGLGIILFSAAVFFQLIT LPVEFNASSRAKQIIVSEGFIRNNEENGVNKVLSAAALTYVAAALVSLFELLRFVMIF LNGRDEN*" /label="yugP CDS" gene complement(2711935..2712612) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /label="yugP gene" downshifts complement(2711945) /Source="Nicolas_upshifts" /id="D1623" /incds=0 /nref=153 /ntot=249 /MaxReadThrough="3.51629" /MaxDrop="4.854" /score="33.0420688" /energy="-13" /TU="U2434,U2435" /idTUdmin="U2435" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" S_feature 2712287..2712963 /Source="Nicolas_S_feature" /locus_tag="new_3217848_3218524" /HighExp="Sw, S8, Salt, BC, S7, Etha, Gly, B36, B60, LPhT" /AntisenseName="yuzI" /AntisenseCor="0.20035821815170399" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1194" promotor_-10 complement(2712647..2712666) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2712654..2712917) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16704729; Product type f : factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097777.1" /db_xref="EnsemblGenomes-Gn:BSU31319" /db_xref="EnsemblGenomes-Tr:CAX52683" /db_xref="GOA:C0H3Q4" /db_xref="UniProtKB/Swiss-Prot:C0H3Q4" /translation="MTIFQRTIVVLIGTQLAASAVILFIFDLNSYNHFSGSFSWLHFL KELAGSFAFYLFSAGLFFLLIGLCAPSRKKKRISVHEKENSLK*" /label="yuzI CDS" gene complement(2712654..2712917) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /label="yuzI gene" upshifts complement(2712668) /Source="Nicolas_upshifts" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2712680..2712687) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2712929..2712947) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2712943) /Source="Nicolas_upshifts" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2712963..2712968) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2712964..2713296 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15731457, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15731457, 23737939, 25297828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="atypical membrane-integrating regulator of biofilm formation (Mistic protein)" /protein_id="YP_003097778.1" /db_xref="EnsemblGenomes-Gn:BSU31321" /db_xref="EnsemblGenomes-Tr:CAX52684" /db_xref="GOA:Q5BU39" /db_xref="InterPro:IPR021078" /db_xref="PDB:1YGM" /db_xref="UniProtKB/Swiss-Prot:Q5BU39" /translation="MFCTFFEKHHRKWDILLEKSTGVMEAMKVTSEEKEQLSTAIDRM NEGLDAFIQLYNESEIDEPLIQLDDDTAELMKQARDMYGQEKLNEKLNTIIKQILSIS VSEEGEKE*" /label="mstX CDS" gene 2712964..2713296 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /label="mstX gene" promotor_-35 2712981..2712987 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2713002..2713019 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2713013 /Source="Nicolas_upshifts" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="upshifts" CDS 2713293..2714279 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16704729, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16704729, 23737939, 25297828; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium channel protein involved in biofilm formation" /protein_id="NP_391010.3" /db_xref="EnsemblGenomes-Gn:BSU31322" /db_xref="EnsemblGenomes-Tr:CAB15121" /db_xref="GOA:Q795M8" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR013099" /db_xref="InterPro:IPR028325" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12369" /db_xref="UniProtKB/Swiss-Prot:Q795M8" /translation="MKSNRIFISWLRWPLFIRIGVIILCLILLFGQIIYILEPKQFTS VFEGIWWAVVTVSTVGYGDYVPHTPLGQAAGILLILSGASFVTAYFATLSAAAFSRQH RYIEGKVAYKGRDHIILIGWNEKTNRLLKDLQLAAPSKTVVLIDESLTEGPLIENVHF IRGHAADDGTLKRANITEAESVMITADQYKSETDADMLSVLTLLSVKGLNPLAYCIVE ILTDRFVTNAERAGANQIIGTSEFISRAMLQHYQVKLRPSKQQNGIKLTLDQHVELLA VPDELKGAAYKTCVLYFLDHNTTIIGIQKKEGPMLSPPLTYKVLETDQFLAI*" /label="kbfO CDS" gene 2713293..2714279 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /label="kbfO gene" downshifts complement(2714254) /Source="Nicolas_upshifts" /id="D1624" /incds=0 /nref=44 /ntot=128 /MaxReadThrough="0.617940000000001" /MaxDrop="4.76695" /score="21.5904825" /energy="-11.3" /TU="NA" /idTUdmin="U2437" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2714276..2714680) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391011.1" /db_xref="EnsemblGenomes-Gn:BSU31330" /db_xref="EnsemblGenomes-Tr:CAB15122" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG12368" /db_xref="UniProtKB/Swiss-Prot:O05246" /translation="MIPIPSAIDGQSFLLQELEQVMKPLGYVINGGWEYDHGYFDYKI DDRDGYLFLRIPVNAVQGSLDERGAAVRIGTPFMLRQVFQADVDDHAEGGPFQSLFNQ FSEPERRDAEIDPAFLDIGASLVKELEDVLLH*" /label="yugN CDS" gene complement(2714276..2714680) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /label="yugN gene" S_feature complement(2714681..2714739) /Source="Nicolas_S_feature" /locus_tag="new_3220242_3220300_c" /HighExp="M0t90, M40t90, S6, S8, S7, T0.30H, Lbstat, M9-stat, T1.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-, SigA" /TUshortPSig="0.686, 0.141, 0.984" /TUlongSig="SigA" /TUlongPSig="0.988" /label="S1195" CDS complement(2714740..2715111) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391012.1" /db_xref="EnsemblGenomes-Gn:BSU31340" /db_xref="EnsemblGenomes-Tr:CAB15123" /db_xref="GOA:O05245" /db_xref="SubtiList:BG12367" /db_xref="UniProtKB/Swiss-Prot:O05245" /translation="MFMKQLVKHLIIAGFSAAILSFLISFDAVYTGFSSSFGGTLSHF FIHSFLLIGLPLALFTDAVHRILHLKRTHTLFTKLGLYATVVYVSWDSAVWLAAAMAV YFLIECAFFPVGRAKETTISM*" /label="yugM CDS" gene complement(2714740..2715111) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /label="yugM gene" CDS complement(2715170..2716522) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /EC_number="5.3.1.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4214896, 4275311, 11489127, 19052382, 21453533, 22720735, 24705866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate isomerase" /protein_id="NP_391013.2" /db_xref="EnsemblGenomes-Gn:BSU31350" /db_xref="EnsemblGenomes-Tr:CAB15124" /db_xref="GOA:P80860" /db_xref="InterPro:IPR001672" /db_xref="InterPro:IPR018189" /db_xref="InterPro:IPR035476" /db_xref="InterPro:IPR035482" /db_xref="SubtiList:BG12366" /db_xref="UniProtKB/Swiss-Prot:P80860" /translation="MTHVRFDYSKALTFFNEHELTYLRDFVKTAHHNIHEKTGAGSDF LGWVDLPEHYDKEEFARIKKSAEKIKSDSDVLLVVGIGGSYLGARAAIEALNHAFYNT LPKAKRGNPQVIFIGNNISSSYMRDVMDLLEDVDFSINVISKSGTTTEPAIAFRIFRK LLEEKYGKEEAKARIYATTDKERGALKTLSNEEGFESFVIPDDVGGRYSVLTAVGLLP IAVSGVNIDDMMKGALDASKDFATSELEDNPAYQYAVVRNVLYNKGKTIEMLINYEPA LQYFAEWWKQLFGESEGKDEKGIYPSSANYSTDLHSLGQYVQEGRRDLFETVLNVEKP KHELTIEEADNDLDGLNYLAGKTVDFVNKKAFQGTMLAHTDGNVPNLIVNIPELNAYT FGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKVNMFALLGKPGFEEKKAELEKRLED *" /label="pgi CDS" gene complement(2715170..2716522) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /label="pgi gene" downshifts complement(2715181) /Source="Nicolas_upshifts" /id="D1625" /incds=0 /nref=90 /ntot=198 /MaxReadThrough="6.86736" /MaxDrop="4.4585" /score="24.139293" /energy="-16.8" /TU="U2437,U2438,U2439" /idTUdmin="U2441" /TUdmin=19 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2715337..2715355) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2715354) /Source="Nicolas_upshifts" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2715371..2715376) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2716495) /Source="Nicolas_upshifts" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2716498..2716509) /Source="Nicolas_upshift_promotors" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2716554..2716573) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2716560) /Source="Nicolas_upshifts" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2716562..2716633) /Source="Nicolas_S_feature" /locus_tag="new_3222123_3222194_c" /HighExp="Etha, H2O2, Paraq, Oxctl, G180, G150, dia5, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.988" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1196" promotor_-35 complement(2716588..2716591) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2716634..2717806) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 1809209, 2673038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase subunit" /protein_id="NP_391014.1" /db_xref="EnsemblGenomes-Gn:BSU31360" /db_xref="EnsemblGenomes-Tr:CAB15125" /db_xref="GOA:O05240" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12365" /db_xref="UniProtKB/Swiss-Prot:O05240" /translation="MENFTYYNPTKLIFGKGQLEQLRKEFKRYGKNVLLVYGGGSIKR NGLYDQVTGILKEEGAVVHELSGVEPNPRLATVEKGIGLCREHDIDFLLAVGGGSVID CTKAIAAGVKYDGDAWDIFSKKVTAEDALPFGTVLTLAATGSEMNPDSVITNWETNEK FVWGSNVTHPRFSILDPENTFTVPENQTVYGMVDMMSHVFEQYFHNVENTPLQDRMCF AVLQTVIETAPKLLEDLENYELRETILYAGTIALNGTLQMGYFGDWASHTMEHAVSAV YDIPHAGGLAILFPNWMRYTLDTNVGRFKNLMLNMFDIDTEGKTDKEIALEGIDKLSA FWTSLGAPSRLADYNIGEEKLELIADIAAKEMEHGGFGNFQKLNKDDVLAILRASL*" /label="bdhK CDS" gene complement(2716634..2717806) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /label="bdhK gene" S_feature 2716969..2717890 /Source="Nicolas_S_feature" /locus_tag="new_3222530_3223451" /HighExp="S6, S7, S8, BT, S5, C30, LBGstat, B36, G135, G150" /AntisenseName="yugK" /AntisenseCor="4.31382473780575E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1197" promotor_-10 complement(2717839..2717858) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-10" upshifts complement(2717852) /Source="Nicolas_upshifts" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="upshifts" promotor_-35 complement(2717875..2717878) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-35" CDS complement(2717910..2719073) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 2673038, 9643546, 11466286, 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase" /protein_id="NP_391015.1" /db_xref="EnsemblGenomes-Gn:BSU31370" /db_xref="EnsemblGenomes-Tr:CAB15126" /db_xref="GOA:O05239" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12364" /db_xref="UniProtKB/Swiss-Prot:O05239" /translation="MQNFTYWNPTKLIFGRGEVERLPEELKPYGKNVLLVYGGGSIKR SGLYDQVIEQLNKAGATVHELAGVEPNPRVSTVNKGVAICKEQNIDFLLAVGGGSVID CTKAIAAGAKYDGDAWDIVTKKHQPKDALPFGTVLTLAATGSEMNSGSVITNWETKEK YGWGSPLVFPKFSILDPVNTFTVPKNHTIYGMVDMMSHVFEQYFHHVSNTPYQDRMCE SLLRTVIETAPKLINDLENYELRETILYTGTIALNGMLSMGARGDWATHNIEHAVSAV YDIPHAGGLAILFPNWMRHTLSENPARMKQLAVRVFDVEEAGKTDEEIALEGIDKLSA FWTSLGAPNRLADYDINDEQLDTIADKAMANGTFGQFKSLNKEDVLSILKASL*" /label="bdhJ CDS" gene complement(2717910..2719073) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /label="bdhJ gene" downshifts complement(2717925) /Source="Nicolas_upshifts" /id="D1626" /incds=0 /nref=167 /ntot=237 /MaxReadThrough="6.69366" /MaxDrop="4.74696" /score="28.8200012" /energy="-13.4" /TU="U2441" /idTUdmin="U2444" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2719088..2719107) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-10" upshifts complement(2719106) /Source="Nicolas_upshifts" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="upshifts" S_feature complement(2719108..2719263) /Source="Nicolas_S_feature" /locus_tag="new_3224669_3224824_c" /HighExp="S8, S7, S4, S5, S6, LoTm, Cold, LBGtran, G180, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25658199999999998" /TUshortSig="SigGF, SigA" /TUshortPSig="0.679, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1198" promotor_-35 complement(2719122..2719129) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-35" promotor_-35 2719159..2719165 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2719180..2719198 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2719190 /Source="Nicolas_upshifts" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2719191..2719249 /Source="Nicolas_S_feature" /locus_tag="new_3224752_3224810" /HighExp="Etha, Salt, Heat, M9-stat, LPhT, Sw, Gly, BC, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1199" promotor_-35 2719236..2719242 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2719238..2719249) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2719251 /Source="Nicolas_upshifts" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2719256..2719267 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2719263..2719269) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2719263) /Source="Nicolas_upshifts" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2719265..2719576) /Source="Nicolas_S_feature" /locus_tag="new_3224826_3225137_c" /HighExp="Cold, LBGtran, LoTm, G180, LBGexp, dia15, G135, H2O2, Paraq, Oxctl" /AntisenseName="yuzA" /AntisenseCor="-0.50065532030853999" /AntisenseRegPval="-17.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1200" CDS 2719303..2719539 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391016.1" /db_xref="EnsemblGenomes-Gn:BSU31380" /db_xref="EnsemblGenomes-Tr:CAB15127" /db_xref="GOA:O32087" /db_xref="InterPro:IPR007211" /db_xref="SubtiList:BG14050" /db_xref="UniProtKB/Swiss-Prot:O32087" /translation="MSTIQRICLVLTIIGAINWGLIGFFQFDLVAAIFGGQGSALSRI IYGLVGIAGLINLGLLFKPNEERSREEAANPEMR*" /label="yuzA CDS" gene 2719303..2719539 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /label="yuzA gene" downshifts 2719499 /Source="Nicolas_upshifts" /id="D1627" /incds=0 /nref=3 /ntot=45 /MaxReadThrough="7.39676" /MaxDrop="2.87922" /score="13.9936296" /energy="-12" /TU="U2442,U2443" /idTUdmin="U2442" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 2719565 /Source="Nicolas_upshifts" /id="D1628" /incds=0 /nref=25 /ntot=56 /MaxReadThrough="1.29261" /MaxDrop="7.50276" /score="13.9936296" /energy="-12" /TU="NA" /idTUdmin="U2442" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2719617..2720009) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 16014871, 19152054, 19636895; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; putative phosphorylase or nucleotidyl transferase; general stress protein" /protein_id="NP_391017.1" /db_xref="EnsemblGenomes-Gn:BSU31390" /db_xref="EnsemblGenomes-Tr:CAB15128" /db_xref="GOA:P80870" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="PDB:2K4K" /db_xref="SubtiList:BG12363" /db_xref="UniProtKB/Swiss-Prot:P80870" /translation="MAAKFEVGSVYTGKVTGLQAYGAFVALDEETQGLVHISEVTHGF VKDINEHLSVGDEVQVKVLAVDEEKGKISLSIRATQAAPEKKESKPRKPKAAQVSEEA STPQGFNTLKDKLEEWIEMSNRKDLIKK*" /label="yugI CDS" gene complement(2719617..2720009) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /label="yugI gene" downshifts complement(2719621) /Source="Nicolas_upshifts" /id="D1629" /incds=0 /nref=232 /ntot=268 /MaxReadThrough="5.9665" /MaxDrop="6.0195" /score="13.5952751" /energy="-15.6" /TU="U2445" /idTUdmin="U2448" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2720051..2720070) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-10" upshifts complement(2720058) /Source="Nicolas_upshifts" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="upshifts" S_feature complement(2720060..2720210) /Source="Nicolas_S_feature" /locus_tag="new_3225621_3225771_c" /HighExp="G180, C30, G135, LBGexp, G150, Oxctl, HPh, Cold, BMM, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1201" promotor_-35 complement(2720086..2720090) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-35" promotor_-35 2720113..2720119 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2720126..2721110 /Source="Nicolas_S_feature" /locus_tag="new_3225687_3226671" /HighExp="LoTm, C30, Salt, S7, S5, S8, Sw, S3, C90, S6" /AntisenseName="yugH" /AntisenseCor="-0.45629591209076698" /AntisenseRegPval="-14.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.662" /TUlongSig="NA" /TUlongPSig="NA" /label="S1202" upshifts 2720126 /Source="Nicolas_upshifts" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2720134..2720152 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2720211..2721371) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /EC_number="2.6.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_391018.2" /db_xref="EnsemblGenomes-Gn:BSU31400" /db_xref="EnsemblGenomes-Tr:CAB15129" /db_xref="GOA:Q795M6" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12362" /db_xref="UniProtKB/Swiss-Prot:Q795M6" /translation="MTSYLSDYVQQIKPSGIRKFFDLAATMEGVISLGVGEPDFVTAW NVREASILSLEQGYTSYTANAGLYSLREEISRYLSNRFDLSYSPDNELIVTVGASQAL DIAIRAIVNPGEEVIIPEPCFVAYDALVSLAGGIPVHVHTTADKGFKATAADFEAAVT EKTKAILICSPSNPTGSVYSKEELNEIAEFAKKHDVIVLADEIYAELTYDEEFTSIAA LPGMKERTVVISGFSKAFAMTGWRLGFAAAPSLLRDAMLKIHQYAMMCAPAMAQFAAL EGLKNGMEDVEKMKKSYRRRRNLFVESLNEIGLSCHHPGGAFYAFPSIKSMGMSSEQF AEELLTQEKVAVVPGSVFGPSGEGYIRCSYATSIEQLQEALVRMKRFLHKTT*" /label="yugH CDS" gene complement(2720211..2721371) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /label="yugH gene" promotor_-35 2721263..2721269 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2721281 /Source="Nicolas_upshifts" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2721283..2721287 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2721372..2721872) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_391019.1" /db_xref="EnsemblGenomes-Gn:BSU31410" /db_xref="EnsemblGenomes-Tr:CAB15130" /db_xref="GOA:O05236" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12361" /db_xref="UniProtKB/Swiss-Prot:O05236" /translation="MKLTEKETEILEILDENSRADLETIAKMAGIPVNEVKTIIDKLE KEKVIIDYSAMIDWRKVDGHEGVTAMIDVKVTPKRGVGFDEVAERIYRFQEVESVYLM SGVYDLSVVIRGNSMSDVARFVSDKLSTLDSVVSTTTHFILKKYKHDGKVFETGDDDK RIVVSP*" /label="yugG CDS" gene complement(2721372..2721872) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /label="yugG gene" promotor_-10 complement(2721902..2721921) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-10" promotor_-35 2721908..2721914 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2721923) /Source="Nicolas_upshifts" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="upshifts" promotor_-10 2721929..2721940 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2721929 /Source="Nicolas_upshifts" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2721932..2721939) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-35" S_feature 2721941..2722019 /Source="Nicolas_S_feature" /locus_tag="new_3227502_3227580" /HighExp="S8, S5, S6, S7, S4, C30, Glucon, Pyr, nit, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1203" CDS 2722020..2722841 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391020.1" /db_xref="EnsemblGenomes-Gn:BSU31420" /db_xref="EnsemblGenomes-Tr:CAB15131" /db_xref="GOA:O05235" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR013595" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12360" /db_xref="UniProtKB/Swiss-Prot:O05235" /translation="MEAVSPIRRFTVDGVNVYYEHYQNPGRQTLVCVHGFLSSAFSFR KVIPLLRDKYDIIALDLPPFGQSEKSRTFIYTYQNLAKLVIGILEHLQVKQAVLVGHS MGGQISLSAALQKPELFSKVVLLCSSGYLKRSHPTIIFGTHIPYFHLYIKRWLSKEGV MKNLLNVVHDKSLIDEEMIDGYGRPFQDEQIFKAMTRFIRHREGDLEPEQLKKMNKPA LLIWGEEDRIVPMEIGKRLHADLPNSVLYSLGQTGHLVPEERPELISEHIADFIK*" /label="yugF CDS" gene 2722020..2722841 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /label="yugF gene" downshifts 2722821 /Source="Nicolas_upshifts" /id="D1630" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="1.0929" /MaxDrop="3.08755" /score="11.2614618" /energy="-6.6" /TU="NA" /idTUdmin="U2449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2722868) /Source="Nicolas_upshifts" /id="D1631" /incds=0 /nref=20 /ntot=156 /MaxReadThrough="2.22671" /MaxDrop="4.10906" /score="25.9859375" /energy="-6.6" /TU="NA" /idTUdmin="U2451" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(2722870..2723130) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391021.2" /db_xref="EnsemblGenomes-Gn:BSU31430" /db_xref="EnsemblGenomes-Tr:CAB15132" /db_xref="InterPro:IPR015053" /db_xref="InterPro:IPR023162" /db_xref="SubtiList:BG12359" /db_xref="UniProtKB/Swiss-Prot:O05234" /translation="MEESHAVREMIKIIAKWDPFKYGEEFYETEAVDVVQAVYDENDP DLLAKSIQQIFETSFEQTLPIASCREVAGQLLFIKNSSSCTP*" /label="yugE CDS" gene complement(2722870..2723130) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /label="yugE gene" promotor_-35 2723120..2723123 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-35" promotor_-10 2723138..2723157 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-10" upshifts 2723150 /Source="Nicolas_upshifts" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="upshifts" S_feature 2723151..2723216 /Source="Nicolas_S_feature" /locus_tag="new_3228712_3228777" /HighExp="dia15, dia5, Lbexp, dia0, LBGtran, G180, Diami, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1204" promotor_-10 complement(2723156..2723175) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2723161) /Source="Nicolas_upshifts" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2723187..2723193) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2723217..2724380 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /EC_number="4.4.1.1" /EC_number="4.4.1.13" /EC_number="4.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15760717, 26337367, 28895253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15760717, 26337367, 28895253; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous cystathionine / cystine beta-lyase /cysteine desulfhydrase" /protein_id="NP_391022.1" /db_xref="EnsemblGenomes-Gn:BSU31440" /db_xref="EnsemblGenomes-Tr:CAB15133" /db_xref="GOA:Q08432" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR027619" /db_xref="SubtiList:BG10744" /db_xref="UniProtKB/Swiss-Prot:Q08432" /translation="MNFDKREERLGTQSVKWDKTGELFGVTDALPMWVADMDFRAPEA ITEALKERLDHGIFGYTTPDQKTKDAVCGWMQNRHGWKVNPESITFSPGVVTALSMAV QAFTEPGDQVVVQPPVYTPFYHMVEKNGRHILHNPLLEKDGAYAIDFEDLETKLSDPS VTLFILCNPHNPSGRSWSREDLLKLGELCLEHGVTVVSDEIHSDLMLYGHKHTPFASL SDDFADISVTCAAPSKTFNIAGLQASAIIIPDRLKRAKFSASLQRNGLGGLNAFAVTA IEAAYSKGGPWLDELITYIEKNMNEAEAFLSTELPKVKMMKPDASYLIWLDFSAYGLS DAELQQRMLKKGKVILEPGTKYGPGGEGFMRLNAGCSLATLQDGLRRIKAALS*" /label="patB CDS" gene 2723217..2724380 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /label="patB gene" promotor_-35 2724443..2724449 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2724461..2724480 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2724471 /Source="Nicolas_upshifts" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2724506..2725792 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9426145, 11069677, 15849754, 16850406, 26152584, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 11069677, 15849754, 16850406, 26152584, 28583948; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-binding histidinekinase" /protein_id="NP_391023.2" /db_xref="EnsemblGenomes-Gn:BSU31450" /db_xref="EnsemblGenomes-Tr:CAB15134" /db_xref="GOA:Q08430" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10745" /db_xref="UniProtKB/Swiss-Prot:Q08430" /translation="MEILKDYLLHICFILFPILLYQVFWLGKPAILVPKINSGLVTLF ACGASVLCIIFPIHEMDYIQYGLQMIPVIICLFYISTASGLTVAASVLCFELLFYEPS AMFVFTLLPFLIIIPILFQKKWPFMSKAKKLLLSLLISCVEIFLFFASSWILSALNIL NFQKSGIFVYEAAVSGLFRSSVLLLSIYIIESIAENIALRSQLIHSEKMTIVSELAAS VAHEVRNPLTVVRGFVQLLFNDETLQNKSSADYKKLVLSELDRAQGIITNYLDMAKQQ LYEKEVFDLSALIKETSSLMVSYANYKSVTVEAETEPDLLIYGDATKLKQAVINLMKN SIEAVPHGKGMIHISAKRNGHTIMINITDNGVGMTDHQMQKLGEPYYSLKTNGTGLGL TVTFSIIEHHHGTISFNSSFQKGTTVTIKLPADLPH*" /label="kinB CDS" gene 2724506..2725792 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /label="kinB gene" S_feature complement(2725508..2726250) /Source="Nicolas_S_feature" /locus_tag="new_3231069_3231811_c" /HighExp="BT, S8, B36, S6, S7, S5, S3, S4, Cold, Pyr" /AntisenseName="kapB" /AntisenseCor="-0.71681066342113797" /AntisenseRegPval="-43" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigK" /TUshortPSig="0.709, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1205" promotor_-35 2725787..2725794 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2725808..2725827 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2725809 /Source="Nicolas_upshifts" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2725838..2726224 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9426145, 23335417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 23335417; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for KinB signal transduction andactivation of the phosphorelay to sporulation" /protein_id="NP_391024.1" /db_xref="EnsemblGenomes-Gn:BSU31460" /db_xref="EnsemblGenomes-Tr:CAB15135" /db_xref="GOA:Q08429" /db_xref="InterPro:IPR014916" /db_xref="SubtiList:BG10746" /db_xref="UniProtKB/Swiss-Prot:Q08429" /translation="MSTFETGSIVKGFYKTGVYIGEITACRPQHYLVKVKAVLTHPAQ GDLHHPKQADVPFFHERKALAYGEQTNIPHHMVKPYDGEVPDYTESLREATAQMRAKL NEDGSEWAKRSLHNLDILEKEYFNRP*" /label="kapB CDS" gene 2725838..2726224 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /label="kapB gene" downshifts 2726206 /Source="Nicolas_upshifts" /id="D1632" /incds=0 /nref=209 /ntot=249 /MaxReadThrough="1.62013" /MaxDrop="5.57132" /score="1.97959632" /energy="-9.2" /TU="NA" /idTUdmin="U2452" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2726251..2726868) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27188294; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exoribonuclease (3'-5')" /protein_id="NP_391025.1" /db_xref="EnsemblGenomes-Gn:BSU31470" /db_xref="EnsemblGenomes-Tr:CAB15136" /db_xref="GOA:O05231" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12358" /db_xref="UniProtKB/Swiss-Prot:O05231" /translation="MTTNSLLIIDFEFTMPDGKYSPQNFFPEIIEAGIVKSIDDEVVE TFSSYVRPKKFPKLTKRCKSFLKITQKQVDEGMRFEDFIRKLNELDPEKNSTIITWGN MDMKVLKQNCMFNHIPFPFKGEMRDLSLEYKNFFGDRTLTGLWKAAEEYGDSGTGTHH KALDDALTAYKLFKLVEQDKQYLEKPKPPTIGERIDLTELLKRAT*" /label="kapD CDS" gene complement(2726251..2726868) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /label="kapD gene" promotor_-10 complement(2726903..2726921) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2726920) /Source="Nicolas_upshifts" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2726922..2729010) /Source="Nicolas_S_feature" /locus_tag="new_3232483_3234571_c" /HighExp="S8, BT, B36, S7, S6, Pyr, C30, B60, S5, G135" /AntisenseName="yuxJ" /AntisenseCor="-0.168930816447634" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1206" promotor_-35 complement(2726936..2726941) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2726984..2726987 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-35" promotor_-10 2727002..2727021 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-10" upshifts 2727013 /Source="Nicolas_upshifts" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="upshifts" CDS 2727079..2728257 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter induced in acid stress" /protein_id="NP_391026.2" /db_xref="EnsemblGenomes-Gn:BSU31480" /db_xref="EnsemblGenomes-Tr:CAB15137" /db_xref="GOA:P40760" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10976" /db_xref="UniProtKB/Swiss-Prot:P40760" /translation="MWLANFFVSASTTMIVPFLSLYIETLSSFSNGFVQRWSGYVFGI TFLMAFLVSPFWGRFGDKRGYKKILMATGTGIALSIFFMGFVTSVYQLFFLRMAMGLV TGFIPTSLAMISAQTPKSSAGKTLGTLQMGQVSGSLFGPLLGGMLADRFGFTYTFFIT SFVIFSSVLLVLFGVKEKHLAEKTAKRTSYSRKEVLSYIFHHPALWVMMLLTMLIQTG NFSIQPLLALYVNELHGPVNLAFFSGMAFSATGLGSLLLARKWGDLGDRYGHRRILIG LLLAASFFFIPQALASSLSVLLVFRFLFGMAMGGLLPCITAAIRVQAPGSIQGEVLGY NVSFRFLGNVLGPLLGGIISSHFTISATFYVTAFLFFAGACMLWIMQKLRKDSYAKAS *" /label="yuxJ CDS" gene 2727079..2728257 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /label="yuxJ gene" promotor_-35 2728295..2728301 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2728313..2728332 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2728318 /Source="Nicolas_upshifts" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="upshifts" CDS 2728350..2730224 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /EC_number="2.-.-.-" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7961491, 9274030; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4" /protein_id="NP_391027.2" /db_xref="EnsemblGenomes-Gn:BSU31490" /db_xref="EnsemblGenomes-Tr:CAB15138" /db_xref="GOA:P40750" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10977" /db_xref="UniProtKB/Swiss-Prot:P40750" /translation="MTMLRKIIGWILLLCIIPLFAFTVIASGKEVKQMKSLDQVLDKN IDLKDISLVQNSYMYDRDGSLVSEIVSDHENRVLVPFNKIPEEVKQIFLTSEDRHFYE HKGFDFMGMVRATASNVKDKKIDQGASTITQQLSRNLYLSHERSFSRKLTELAYSYQL EKKYTKNEILEAYLNTIYFNNGVYGVGSAAQFYFSKPLKSLTVGEMAFICAIPNNPTL YDPLKHFDYTKSRQERLLKGLKDAGVITDKELKKAVKQKIKLDVEKREDKYPDYVSYV NDEFTQLVSESEGFDKRLQKASGKQKEKIENELSARVSTLMKDGVKIYTALDPYMQNQ VVAQMNSKLPYADVQGGAAVINHQTHQIIALSGGKNYQKYDFNRAYQAYRQPGSSIKP LLDYGPYIEQTGATTSSTIDASKFCSKDYCPQNYNNRTYGTVTLDTAFKNSYNTPAIR MLDRVGIQKAFSYIEPYHFAKLVDSDYLLPAALGGFTNGMTPLEMTKAYTTFGNSGSY TPSHAITKVTDLKGKTLYKWNDKATQIFSVRTNMQLKKLMSSVVKSGTGKKAYFNAPY IGGKTGTSNDYHDMWFVGLTDTYTMGVWVGKDTPTSVEYLHSISPQLSIWKGTLQAAY *" /label="pbpD CDS" gene 2728350..2730224 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /label="pbpD gene" promotor_-10 complement(2728990..2729009) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2729010) /Source="Nicolas_upshifts" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2729023..2729032) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2730245..2730658 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26335199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase" /protein_id="NP_391028.1" /db_xref="EnsemblGenomes-Gn:BSU31500" /db_xref="EnsemblGenomes-Tr:CAB15139" /db_xref="InterPro:IPR007263" /db_xref="SubtiList:BG10978" /db_xref="UniProtKB/Swiss-Prot:P40761" /translation="MTSEQIPNRVLLFDGVCNLCNGAVQFIIKRDPDGLISFTSLQSE TGQSLLKKSGLPTDRFDSFVFIEDGQVYTKSTAAIKVFRHLRGPWRLFVLFFAVPKPV RDMVYSFIAKNRYKWFGKKNECMLPSPSIKKRFLP*" /label="yuxK CDS" gene 2730245..2730658 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /label="yuxK gene" downshifts 2730650 /Source="Nicolas_upshifts" /id="D1633" /incds=0 /nref=1 /ntot=254 /MaxReadThrough="5.05064" /MaxDrop="3.14634" /score="-3.58105315" /energy="-11.5" /TU="U2456" /idTUdmin="U2456" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2730861..2731418) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391029.2" /db_xref="EnsemblGenomes-Gn:BSU31510" /db_xref="EnsemblGenomes-Tr:CAB15140" /db_xref="GOA:O05249" /db_xref="InterPro:IPR035289" /db_xref="SubtiList:BG12346" /db_xref="UniProtKB/Swiss-Prot:O05249" /translation="MKNTYLTGYFPLIAILLFSSSLSISTSLYALKMLSSFGMYDGML DYFSEKGIRLALFAAFALLYFMVLSALKLIANTVTELSLLFFANDPEGNNLKKLRMGS MIYLGGGILSFVLLQNVIWIVIWFAVVTLAYFVFTVYRIYSTLSLMSLVGFILLELLF WFTFVIGILFIFIKLYNSIMASLPV*" /label="yufK CDS" gene complement(2730861..2731418) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /label="yufK gene" misc_feature 2730882..2730901 /Source="Nicolas_upshift_promotors" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2730892 /Source="Nicolas_upshifts" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2730902) /Source="Nicolas_upshifts" /id="D1634" /incds=0 /nref=10 /ntot=201 /MaxReadThrough="3.90201" /MaxDrop="3.94501" /score="-6.00543052" /energy="-18.5" /TU="U2459" /idTUdmin="U2459" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 2730914..2731595 /Source="Nicolas_S_feature" /locus_tag="new_3236475_3237156" /HighExp="Diami, Cold, LBGstat, H2O2, Lbtran, Gly, M0t90, GM 10, GM-0.2, dia15" /AntisenseName="yufK" /AntisenseCor="0.32488342936044701" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.878" /TUlongSig="NA" /TUlongPSig="NA" /label="S1207" promotor_-10 complement(2731444..2731463) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2731452) /Source="Nicolas_upshifts" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2731479..2731483) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2731596..2733197 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [MaeM]" /protein_id="NP_391030.1" /db_xref="EnsemblGenomes-Gn:BSU31520" /db_xref="EnsemblGenomes-Tr:CAB15141" /db_xref="GOA:O05250" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12347" /db_xref="UniProtKB/Swiss-Prot:O05250" /translation="MKKTLKLQTRLTIFVCIVVLIALLITFFTVGAQTTKRIRDQEKA TALQTAEMVAEAPMTAAALESGKKQKELQSYTKRVQKITGTEFVVVMDMNGIRKTHPD PSKIGKKFRGGDESEVLKGHVHISTASGTLGKSQRAFVPVYAENGKQVGAVAVGITVN EIDEVISHSLRPLYFIICVSIFVGVIGAVIVARTVKNIMYGLEPYEIATLLEERSAML ESTKEGILAVDEHGKIKLANAEAKRLFVKMGINTNPIDQDVDDILPKSRLKKVIETKK PLQDRDVRINGLELVFNEVPIQLKGQTVGAIATFRDKTEVKHLAEQLSGVKMYANALR AQSHEFMNKLHVILGLVQLKEYDDLGDYIKDIAIQQKSETSEIINDVKSSVLAGFLLG KQSFIREQGANLDIECNGVIPNAADPSVIHELITIIGNLINNGLDAVADMPKKQITMS MRFHNSILDIEITDTGAGMSEEDQAKVFEQGYSTKGKNRGFGLYFTQQSIENLKGQMI LTSEKNEGTTFSIRIPYEPKEENHD*" /label="maeL CDS" gene 2731596..2733197 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /label="maeL gene" CDS 2733190..2733897 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator for malate metabolism [MaeL]" /protein_id="NP_391031.1" /db_xref="EnsemblGenomes-Gn:BSU31530" /db_xref="EnsemblGenomes-Tr:CAB15142" /db_xref="GOA:O05251" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12348" /db_xref="UniProtKB/Swiss-Prot:O05251" /translation="MINVLIVEDDPMVGELNKRYLSQIDGFQLKGIASSFQSALHILG EHHIDLILLDIYMPGKNGLELLTELRAQNEAVDVIVISAASELDVIKKTLRYGAVDYL IKPFEFERFQTALSDYRRKQKVYSTHRNMSQKELDAELFQKKEATEKVQLPKGLTKST LKLIWSSIQSFENESFTTEDLAKHTEISQVSIRKYLKFLEDIQVLNVEMAYGTIGRPV FQYNVNNSNINGIKQYL*" /label="maeM CDS" gene 2733190..2733897 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /label="maeM gene" downshifts 2733882 /Source="Nicolas_upshifts" /id="D1635" /incds=0 /nref=173 /ntot=245 /MaxReadThrough="1.97489" /MaxDrop="5.86018" /score="19.9464971" /energy="-15.3" /TU="NA" /idTUdmin="U2458" /TUdmin=2660 /isTUend="FALSE" /label="downshifts" promotor_-35 2734061..2734068 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2734079..2734368 /Source="Nicolas_S_feature" /locus_tag="new_3239640_3239929" /HighExp="T1.30H, T1.0H, T2.30H, T2.0H, M9-stat, S1, T3.0H, T3.30H, T0.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1208" upshifts 2734079 /Source="Nicolas_upshifts" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2734083..2734102 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2734369..2735448 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in guanosine transport" /protein_id="NP_391032.2" /db_xref="EnsemblGenomes-Gn:BSU31540" /db_xref="EnsemblGenomes-Tr:CAB15143" /db_xref="GOA:O05252" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12349" /db_xref="UniProtKB/Swiss-Prot:O05252" /translation="MNKRKIGLAMSLVIAAGTILGACGNSEKSSGSGEGKNKFSVAMV TDVGGVDDKSFNQSAWEGIQAFGKENGLKKGKNGYDYLQSKSDADYTTNLNKLARENF DLIYGVGYLMEDSISEIADQRKNTNFAIIDAVVDKDNVASITFKEQEGSFLVGVAAAL SSKSGKIGFVGGMESELIKKFEVGFRAGVQAVNPKAVVEVKYAGGFDKADVGKATAES MYKSGVDVIYHSAGATGTGVFTEAKNLKKEDPKRDVWVIGVDKDQYAEGQVEGTDDNV TLTSMVKKVDTVVEDVTKKASDGKFPGGETLTYGLDQDGVGISPSKQNLSDDVIKAVD KWKKKIIDGLEIPATEKELKTFKAE*" /label="nupN CDS" gene 2734369..2735448 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /label="nupN gene" CDS 2735524..2737056 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanosine ABC transporter (ATP-binding protein)" /protein_id="NP_391033.1" /db_xref="EnsemblGenomes-Gn:BSU31550" /db_xref="EnsemblGenomes-Tr:CAB15144" /db_xref="GOA:O05253" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12350" /db_xref="UniProtKB/Swiss-Prot:O05253" /translation="MEYVIEMLNIRKAFPGIVANDNINLQVKKGEIHALLGENGAGKS TLMNVLFGLYQPERGEIRVRGEKVHINSPNKANDLGIGMVHQHFMLVDTFTVAENIIL GKEPKKFGRIDRKRAGQEVQDISDRYGLQIHPEAKAADISVGMQQRAEILKTLYRGAD ILIFDEPTAVLTPHEIKELMQIMKNLVKEGKSIILITHKLKEIMEICDRVTVIRKGKG IKTLDVRDTNQDELASLMVGREVSFKTEKRAAQPGAEVLAIDGITVKDTRGIETVRDL SLSVKAGEIVGIAGVDGNGQSELIEAVTGLRKTDSGTITLNGKQIQNLTPRKITESGI GHIPQDRHKHGLVLDFPIGENILLQSYYKKPYSALGVLHKGEMYKKARSLITEYDVRT PDEYTHARALSGGNQQKAIIGREIDRNPDLLIAAQPTRGLDVGAIEFVHKKLIEQRDA GKAVLLLSFELEEIMNLSDRIAVIFEGRIIASVNPQETTEQELGLLMAGSTQKEAGKA NG*" /label="nupO CDS" gene 2735524..2737056 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /label="nupO gene" CDS 2737049..2738095 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391034.1" /db_xref="EnsemblGenomes-Gn:BSU31560" /db_xref="EnsemblGenomes-Tr:CAB15145" /db_xref="GOA:O05254" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR002229" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12351" /db_xref="UniProtKB/Swiss-Prot:O05254" /translation="MVKRLSHLLVPLIAIILGLAAGALIMLVSGYSVASGYSALWNGI FGEIYYVGETIRQITPYILSGLAVAFAFRTGLFNIGVEGQLLVGWTAAVWVGTAFDGP AYIHLPLALITAAAAGGLWGFIPGILKARFYVHEVIVTIMMNYIALHMTNYIISNVLT DHQDKTGKIHESASLRSPFLEQITDYSRLHLGIIVALLAAVIMWFIINKSTKGFELRA VGFNQHASQYAGMSVRKNIMTSMLISGAFAGLAGAMEGLGTFEYAAVKGAFTGVGFDG IAVALLGGNTAVGVVLAACLLGGLKIGALNMPIESGVPSEVVDIVIAIIILFVASSYA IRFVMGKLKKKGAN*" /label="nupP CDS" gene 2737049..2738095 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /label="nupP gene" CDS 2738096..2739055 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391035.1" /db_xref="EnsemblGenomes-Gn:BSU31570" /db_xref="EnsemblGenomes-Tr:CAB15146" /db_xref="GOA:O05255" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12352" /db_xref="UniProtKB/Swiss-Prot:O05255" /translation="MDIVQILSIIVPATLVYAAPLILTALGGVFSERSGVVNIGLEGL MIIGAFTSVLFNLFFGQELGAAAPWLSLLAAMAAGALFSLIHAAAAISFRADQTVSGV AINMLALGATLFIVKLIYGKAQTDKIPEPFYKTKIPGLGDIPVLGKIFFSDVYYTSIL AIALAFISWFILFKTPFGLRIRSVGEHPMAADTMGINVYKMRYIGVMISGLFGGLGGG VYASTIALDFTHSTISGQGFIALAALVFGKWHPIGALGAALFFGFAQSLSIIGSLLPL FKDIPNVYMLMAPYILTILALTGFIGRADAPKANGVPYIKGKR*" /label="nupQ CDS" gene 2738096..2739055 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /label="nupQ gene" S_feature 2739056..2739177 /Source="Nicolas_S_feature" /locus_tag="new_3244617_3244738" /HighExp="S1, BT, M9-stat, T1.30H, S2, LoTm, T1.0H, T2.30H, T2.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1209" promotor_-35 2739150..2739153 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2739168..2739187 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2739179 /Source="Nicolas_upshifts" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="upshifts" CDS 2739209..2740555 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/malate symporter" /protein_id="NP_391036.1" /db_xref="EnsemblGenomes-Gn:BSU31580" /db_xref="EnsemblGenomes-Tr:CAB15147" /db_xref="GOA:O05256" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12353" /db_xref="UniProtKB/Swiss-Prot:O05256" /translation="MGAIPKTGTISPEQKDSQEKNLFQKIWSWEIGVIPLPLYTVLAV IIILAAYYNELPANMLGGFAIIMILGVFLGDIGQRIPILKDIGGPAILSLFVPSFLVF YNVLNSTSLDAVTNLMKTSNFLYFYIACLVVGSILGMNRIVLIQGFIRMFVPLVAGTI AAVAAGILVGFIFGYSAYDSFFFVVVPIIAGGIGEGILPLSIAYSQILGSSADVFVSQ LVPAAIIGNVFAIICAALMKKLGDKRPDLNGNGRLVKSKKANEIFNQKEAEAKIDFKL MGAGVLLACTFFIFGGLLEKFIFIPGAILMIISAAAVKYANILPKKMEEGAYQLYKFI SSSFTWPLMVGLGILFIPLDDVASVISIPFVIICISVVIAMIGSGYFVGKLMNMYPVE SAIVTCCHSGLGGTGDVAILSASGRMGLMPFAQISTRLGGAGTVICATVLLRFFTS*" /label="maeN CDS" gene 2739209..2740555 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /label="maeN gene" downshifts 2740538 /Source="Nicolas_upshifts" /id="D1636" /incds=0 /nref=68 /ntot=109 /MaxReadThrough="0.286069999999999" /MaxDrop="6.51197" /score="36.240717" /energy="-12.2" /TU="NA" /idTUdmin="U2461" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(2740591..2740806) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391037.1" /db_xref="EnsemblGenomes-Gn:BSU31590" /db_xref="EnsemblGenomes-Tr:CAB15148" /db_xref="GOA:O05257" /db_xref="SubtiList:BG12354" /db_xref="UniProtKB/Swiss-Prot:O05257" /translation="MKTKVVMCSGLFCSVFAGAFMLNQYDGRSGVAACDEWELYLLEH HLSARMSETESKDLPFGPREYIRIVNK*" /label="yufS CDS" gene complement(2740591..2740806) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /label="yufS gene" promotor_-35 2740746..2740752 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2740766..2740777 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2740770 /Source="Nicolas_upshifts" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2740817..2740835) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2740824) /Source="Nicolas_upshifts" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2740849..2740856 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2740851..2740856) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2740871..2740966 /Source="Nicolas_S_feature" /locus_tag="new_3246432_3246527" /HighExp="G180, Diami, G150, Oxctl, G135, H2O2, Paraq, MG 60, MG 15, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1210" promotor_-10 2740871..2740890 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2740871 /Source="Nicolas_upshifts" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2740929..2740933 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2740949..2740968 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2740968..2741117 /Source="Nicolas_S_feature" /locus_tag="new_3246529_3246678" /HighExp="G135, G180, Diami, G150, H2O2, Oxctl, LBGexp, Paraq, Salt, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1211" upshifts 2740968 /Source="Nicolas_upshifts" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2741037..2743442 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium transporter component of a Na+/H+ antiporter" /protein_id="NP_391038.2" /db_xref="EnsemblGenomes-Gn:BSU31600" /db_xref="EnsemblGenomes-Tr:CAB15149" /db_xref="GOA:Q9K2S2" /db_xref="InterPro:IPR001516" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR005663" /db_xref="InterPro:IPR018393" /db_xref="InterPro:IPR025383" /db_xref="SubtiList:BG12355" /db_xref="UniProtKB/Swiss-Prot:Q9K2S2" /translation="MQLLHLAILSPFLFAFIIPFLAKYAKRVHTGWFVLILPVLLFIY FLPMIRMTQSGETLRSVLEWIPSLGINFTVYIDGLGLLFALLITGIGSLVTLYSIFYL SKEKEQLGPFYVYLLMFMGAMLGVVLVDNVMVLYMFWELTSLSSFLLIGYWYKREKSR YGAAKSLLITVSGGLCMLGGFILLYLITDSFSIREMVHQVQLIAGHELFIPAMILILL GAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGIYVIARFSPIFAFSAQWFWI VSLVGLFTMVWGSFHAVKQTDLKSILAFSTVSQLGMIISMLGVSAAALHYGHTEYYTV AAMAAIFHLINHATFKGSLFMAVGIIDHETGTRDIRKLGGLMAIMPITFTISLIGTFS MAGLPPFNGFLSKEMFFTSMLRVTHFDLFNVQTWGVLFPLFAWIGSVFTFIYSMKLLF KTFRGNYQPEQLEKQAHEAPVGMLVPPVILVALAVSLFFFPNILSYSLIEPAMNSIYP TLLDGHEKFHVHISQWHGVTTELLMTAGIVVIGTIGYLSLNKWKGIYKLFPSKLTLNR LYDKLLTMMEKGSYRVTKQYMTGFLRDYLLYIFAGFIILIGGAFAIKGGFSFKTEGMA KIGVYEIILTLVMISATVATVFARSRLTAIIALGVVGYTLALFFVIFRAPDLALTQLV IETISVALFLLCFYHLPKLRLKTKTRTFRMTNFIISLGVGVIVTLLGIASSSQRTKDS IASFFVKHSHDLGGGDNVVNVILVDFRGFDTMFEITVLTIAALGIYSMIKTKVKEEGK SGE*" /label="mrpA CDS" gene 2741037..2743442 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /label="mrpA gene" CDS 2743435..2743866 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter complex" /protein_id="NP_391039.1" /db_xref="EnsemblGenomes-Gn:BSU31610" /db_xref="EnsemblGenomes-Tr:CAB15150" /db_xref="GOA:O05259" /db_xref="InterPro:IPR005281" /db_xref="InterPro:IPR007182" /db_xref="SubtiList:BG12356" /db_xref="UniProtKB/Swiss-Prot:O05259" /translation="MNEQKTNDLILQTATKLVSFIILLFSFYLFLSGHNAPGGGFVGG LITSSSIVLLLLAYDLKTVRSLLPVNFIYVAGAGLLLAVLTGVGSFVFGAPFLTHTFG YFQLPILGKTELATATIFDLGVYLVVVGITMTIIQTIGEEE*" /label="mrpB CDS" gene 2743435..2743866 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /label="mrpB gene" CDS 2743866..2744207 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of Na+/H+ antiporter" /protein_id="NP_391040.2" /db_xref="EnsemblGenomes-Gn:BSU31620" /db_xref="EnsemblGenomes-Tr:CAB15151" /db_xref="GOA:O05260" /db_xref="SubtiList:BG12357" /db_xref="UniProtKB/Swiss-Prot:O05260" /translation="MEILMAVLAGIIFMAATYLLLSKSLLRVIIGTALLSHGVHLMLL TMGGLKKGAAPILSEHAKSFVDPLPQALILTAIVISFGVTSFILVMAFRAYQELKSDD MDQMRGNDQHE*" /label="mrpC CDS" gene 2743866..2744207 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /label="mrpC gene" promotor_no_box 2744098..2744198 /Source="Nicolas_upshift_promotors" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2744158 /Source="Nicolas_upshifts" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2744200..2745681 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton transporter component of Na+/H+ antiporter" /protein_id="NP_391041.3" /db_xref="EnsemblGenomes-Gn:BSU31630" /db_xref="EnsemblGenomes-Tr:CAB15152" /db_xref="GOA:O05229" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR003918" /db_xref="InterPro:IPR004775" /db_xref="SubtiList:BG12345" /db_xref="UniProtKB/Swiss-Prot:O05229" /translation="MNNFVILPILIPLLSAILLIFMTKNLMLMRIFSTAASAIGIVIS GILVQTVFTKGIQTLSLGGWKAPYGIVLAADQFASLLVLTTAIIGLLVGLYSFRSVGE KRERSFYYSGVQFLLAGVSGAFLTGDLFNMYVFFELLLIASYMLIVLGGTKIQLRESL KYIVFNIVSSALFVIGVGFLYAVTGTLNMADLSVKISESGQTGLITVIGVLLLLVFGM KGGIFPLYFWLPGSYYAPPAAISALFGALLTKVGLYAITRVFTLIFIHDTAFTHQLMI WLAALTVIFGVIGSLAYSNVMKIVIYNIITAVGVILFGVAVHTPASIQGAIYYLIHDM LIKGALFMLAGTLIALTGTASLHKMGGLIKRYPVLGWMFFISAISLAGIPPLSGFVGK FKIAEGGFAEGEFTISMLILLSSLLVLYSVLRIFIHAFWGEEKETPKPNHRTAKGLLY PAAIFLLLSLLFGLGTEWVSPYVDQAAETLLNPEKYIEAVLKE*" /label="mrpD CDS" gene 2744200..2745681 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /label="mrpD gene" S_feature complement(2744933..2746801) /Source="Nicolas_S_feature" /locus_tag="new_3250494_3252362_c" /HighExp="S2, Lbstat, T5.0H, T3.30H, S3, T4.0H, T3.0H, T2.30H, S1, T2.0H" /AntisenseName="mrpD" /AntisenseCor="-0.59706140653928796" /AntisenseRegPval="-26.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1212" CDS 2745687..2746163 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 15849754, 16233411, 16850406, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 15849754, 16233411, 16850406, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="YP_054591.2" /db_xref="EnsemblGenomes-Gn:BSU31640" /db_xref="EnsemblGenomes-Tr:CAE01465" /db_xref="GOA:Q7WY60" /db_xref="InterPro:IPR002758" /db_xref="SubtiList:BG14181" /db_xref="UniProtKB/Swiss-Prot:Q7WY60" /translation="MAFQILLNVFLAFCWMFLSNSPSAAGFITGYILGMLSLFFFRRF FTRQFYLWKLISIIKLCFIFIKELYLANVSVMKSVLSPKLNIRPGIFAFKTELTKDWE ITMLSLLITLTPGTLVMDISDDRTILYIHAMDIEDAEKAIFDIRESFEKAIQEVSR*" /label="mrpE CDS" gene 2745687..2746163 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /label="mrpE gene" CDS 2746163..2746447 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 11356194, 12682299, 15019740, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 11356194, 12682299, 15019740, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter for Na+ and cholate" /protein_id="NP_391043.2" /db_xref="EnsemblGenomes-Gn:BSU31650" /db_xref="EnsemblGenomes-Tr:CAB15153" /db_xref="GOA:O05228" /db_xref="InterPro:IPR007208" /db_xref="SubtiList:BG12344" /db_xref="UniProtKB/Swiss-Prot:O05228" /translation="MFTLILQIALGIMAVSTFLYVIRVIKGPTVPDRVVALDAIGINL IAITALVSILLKTSAFLDIILLLGILSFIGTIAFSKFLEKGEIIENDRNR*" /label="mrpF CDS" gene 2746163..2746447 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /label="mrpF gene" CDS 2746431..2746805 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 15019740, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 15019740, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="NP_391044.1" /db_xref="EnsemblGenomes-Gn:BSU31660" /db_xref="EnsemblGenomes-Tr:CAB15154" /db_xref="GOA:O05227" /db_xref="InterPro:IPR005133" /db_xref="SubtiList:BG12343" /db_xref="UniProtKB/Swiss-Prot:O05227" /translation="MIETAKVVVAVFILLGALICLIASFGVLRLPDVFTRAHAASKGS TLGVNMILLGVFFYLWFVTGELSAKILLGILFIFITSPIGGHLICRAAYNSGVKLDER SVQDDYNGIRNFVIKRKEDSYL*" /label="mrpG CDS" gene 2746431..2746805 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /label="mrpG gene" downshifts 2746776 /Source="Nicolas_upshifts" /id="D1637" /incds=0 /nref=86 /ntot=185 /MaxReadThrough="1.46493" /MaxDrop="6.023" /score="32.1865197" /energy="-12.7" /TU="NA" /idTUdmin="U2464" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2746844..2747224) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /EC_number="3.1.-.-" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25010423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proofreading thioesterase in bacillibactin biosynthesis" /protein_id="NP_391045.2" /db_xref="EnsemblGenomes-Gn:BSU31670" /db_xref="EnsemblGenomes-Tr:CAB15155" /db_xref="GOA:P14205" /db_xref="InterPro:IPR003736" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10382" /db_xref="UniProtKB/Swiss-Prot:P14205" /translation="MDMKHTLLEALGIEIVENTAERCVAVMPVDHRTVQPFGYLHGGA SVALAETAASAGAQNLIDHTTQACVGLEINANHLKSVKEGTVKAIAEPVHIGRTTIVY HIHIYDEQERLICISRCTLAVIKK*" /label="yuxO CDS" gene complement(2746844..2747224) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /label="yuxO gene" downshifts complement(2746846) /Source="Nicolas_upshifts" /id="D1638" /incds=0 /nref=41 /ntot=206 /MaxReadThrough="4.53972" /MaxDrop="3.98532" /score="-4.4938943" /energy="-12.7" /TU="U2469" /idTUdmin="U2469" /TUdmin="-1050" /isTUend="FALSE" /label="downshifts" CDS complement(2747243..2747887) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response quorum-sensing regulator" /protein_id="NP_391046.1" /db_xref="EnsemblGenomes-Gn:BSU31680" /db_xref="EnsemblGenomes-Tr:CAB15156" /db_xref="GOA:P14204" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2KRF" /db_xref="PDB:3ULQ" /db_xref="SubtiList:BG10381" /db_xref="UniProtKB/Swiss-Prot:P14204" /translation="MKKILVIDDHPAVMEGTKTILETDSNLSVDCLSPEPSEQFIKQH DFSSYDLILMDLNLGGEVNGMELSKQILQENPHCKIIVYTGYEVEDYFEEAIRAGLHG AISKTESKEKITQYIYHVLNGEILVDFAYFKQLMTQQKTKPAPSSQKEQDVLTPRECL ILQEVEKGFTNQEIADALHLSKRSIEYSLTSIFNKLNVGSRTEAVLIAKSDGVL*" /label="comA CDS" gene complement(2747243..2747887) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /label="comA gene" S_feature complement(2747888..2747967) /Source="Nicolas_S_feature" /locus_tag="new_3253449_3253528_c" /HighExp="S2, Lbstat, M0t90, M40t90, MG 5, S1, ferm, T1.30H, nit, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1213" CDS complement(2747968..2750277) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /EC_number="2.7.-.-" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7698645, 7855425, 10419951, 14679219, 15066026, 16091050, 16787201, 20208433, 24130811; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_391047.2" /db_xref="EnsemblGenomes-Gn:BSU31690" /db_xref="EnsemblGenomes-Tr:CAB15157" /db_xref="GOA:Q99027" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10380" /db_xref="UniProtKB/Swiss-Prot:Q99027" /translation="MKNLIKKFTIAVIVLSILYISYTTYISMNGIIIGTKIHKNDKSQ FMIEEISESSYGQFVGLRQGDIILKINKEKPSDKHLKWGYLSHINSLDILRSGKKIHL KDFDLVTLNRPYSFFLFVLPLFFYFLSIICIFYILKVNKKRRSFAAYILILLLLDISI AYISAGGPFRGHIINRYINLFTFISSPILYLQFIQRYLGEIGKTFLNRISFLYIIPIF NLGIEFFQDYLQVDIDFLATLNLVSFATLTLFSFSAIYLHLNKYKYAEHSFILKLLIL TNTLSFAPFLIFFVLPIIFTGNYIFPALASASLLVLIPFGLVYQFVANKMFDIEFILG RMRYYALLAMIPTLLIVGALVLFDVMDIQMNPVRQTVFFFVVMFAVFYFKEVMDFKFR LKRFSEKFNYQDSIFKYTQLMRGVTSLQQVFKELKNTILDVLLVSKAYTFEVTPDHKV IFLDKHEVGPDWNFYQEEFENVTSEIGKIIEVNQGFLMKVGERGGSSYVLLCLSNINT PRLTRDEISWLKTLSFYTSVSMENVLHIEELMEHLKDLKQEGTNPIWLKKLMFAIEEK QRSGLARDLHDSVLQDLISLKRQCELFLGDFKKDDNPCREEVQDKLVQMNEQMSDVIS MTRETCHELRPQLLYDLGLVKALSKLVAQQQERVPFHIRLNTGRFTASLDLDSQLNLY RIIQEFLSNAVKHSQATDVLIMLISIQNKIVLHYEDDGVGFDQEKNTEHSMSMGLSGI KERVRALDGRLRIETSEGKGFKADIEIEL*" /label="comP CDS" gene complement(2747968..2750277) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /label="comP gene" promotor_-35 2748962..2748969 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2748983..2749002 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2748998 /Source="Nicolas_upshifts" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 2749871..2750842 /Source="Nicolas_S_feature" /locus_tag="new_3255432_3256404" /HighExp="S8, C30, S7, Gly, Lbstat, Fru, C90, Pyr, G135, M/G" /AntisenseName="comX" /AntisenseCor="-2.6572990440080099E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.606" /TUlongSig="NA" /TUlongPSig="NA" /label="S1214" upshifts 2749871 /Source="Nicolas_upshifts" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2749883..2749899 /Source="Nicolas_upshift_promotors" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2750292..2750459) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484; Product type f: factor" /codon_start=1 /transl_table=11 /product="competence pheromone precursor (pheromone peptide aa 46->55, geranyl-modified)" /protein_id="NP_391048.1" /db_xref="EnsemblGenomes-Gn:BSU31700" /db_xref="EnsemblGenomes-Tr:CAB15158" /db_xref="GOA:P45453" /db_xref="InterPro:IPR009233" /db_xref="SubtiList:BG11324" /db_xref="UniProtKB/Swiss-Prot:P45453" /translation="MQDLINYFLNYPEALKKLKNKEACLIGFDVQETETIIKAYNDYY LADPITRQWGD*" /label="comX CDS" gene complement(2750292..2750459) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /label="comX gene" CDS complement(2750447..2751345) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoprenyl transferase (pre-ComX modification)" /protein_id="NP_391049.2" /db_xref="EnsemblGenomes-Gn:BSU31710" /db_xref="EnsemblGenomes-Tr:CAB15159" /db_xref="GOA:P33690" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033965" /db_xref="SubtiList:BG10379" /db_xref="UniProtKB/Swiss-Prot:P33690" /translation="MKEIVEQNIFNEDLSQLLYSFIDSKETFSFAESTILHYVVFGGE NLDVATRLGAGIEILILSSDIMDDLEDEDNHHALWMKINRSESLNAALSLYTVGLTSI YSLNNNPLIFKYVLKYVNEAMQGQHDDITNKSKTEDESLEVIRLKCGSLIALANVAGV LLATGEYNETVERYSYYKGIIAQISGDYYVLLSGNRSDIEKNKHTLIYLYLKRLFNDA SEDLLYLISHKDLYYKSLLDKEKFQEKLIKAGVTQYISVLLEIYKQKCISAIEQLNLD KEKKS**RNAY*VIQRGIQDARP" /label="comQ CDS" gene complement(2750447..2751345) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /label="comQ gene" S_feature complement(2751346..2751459) /Source="Nicolas_S_feature" /locus_tag="new_3256908_3257021_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, S4, T2.30H, M0t90, S5, M40t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1215" promotor_-10 complement(2751453..2751472) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2751459) /Source="Nicolas_upshifts" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2751486..2751492) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2751530..2751670) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="pleiotropic regulator" /protein_id="NP_391050.1" /db_xref="EnsemblGenomes-Gn:BSU31720" /db_xref="EnsemblGenomes-Tr:CAB15160" /db_xref="GOA:Q99039" /db_xref="InterPro:IPR012554" /db_xref="SubtiList:BG10378" /db_xref="UniProtKB/Swiss-Prot:Q99039" /translation="MEKKLEEVKQLLFRLELDIKETTDSLRNINKSIDQLDKYNYAMK IS*" /label="degQ CDS" gene complement(2751530..2751670) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /label="degQ gene" downshifts complement(2751559) /Source="Nicolas_upshifts" /id="D1639" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="2.48672" /MaxDrop="4.10905" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2470" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2751671..2751757) /Source="Nicolas_S_feature" /locus_tag="new_3257233_3257319_c" /HighExp="S2, S4, BC, M9-stat, S5, S3, S6, BT, S8, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.843" /TUlongSig="NA" /TUlongPSig="NA" /label="S1216" promotor_-10 complement(2751741..2751760) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2751757) /Source="Nicolas_upshifts" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2751774..2751780) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2751857..2751875) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2751867) /Source="Nicolas_upshifts" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2751890..2751896) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2751892..2752017 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514001.1" /translation="MLKLRKILNLLDFNGFRIFTKQDYSPSYRIFKIEYAILGVS*" /label="hypothetical protein CDS" gene 2751892..2752017 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /label="gene" S_feature complement(2752045..2752474) /Source="Nicolas_S_feature" /locus_tag="new_3257607_3258036_c" /HighExp="LBGtran, G135, C90, Lbtran, Mt0, Lbexp, G150, G180, M40t45, C30" /AntisenseName="yuzC" /AntisenseCor="-0.77553193168722701" /AntisenseRegPval="-54.5" /CDS_PredictionProba="0.143959" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1217" promotor_-35 2752070..2752075 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2752087) /Source="Nicolas_upshifts" /id="D1640" /incds=0 /nref=23 /ntot=170 /MaxReadThrough="2.53578" /MaxDrop="3.52021" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2473" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 2752090..2752108 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2752092 /Source="Nicolas_upshifts" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="upshifts" CDS 2752131..2752499 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391051.2" /db_xref="EnsemblGenomes-Gn:BSU31730" /db_xref="EnsemblGenomes-Tr:CAB15161" /db_xref="InterPro:IPR016559" /db_xref="SubtiList:BG14052" /db_xref="UniProtKB/Swiss-Prot:O32089" /translation="MRYRYPWFYVYPYEVRRPPAPANNIDTFIRSAKQAAGIFADAQL VLSRIAGSRELSRRILTAAEQSDKQTIRRLIKQMGVRHEVDTVFNPDGIYISLIGTQS RMILALRWSEDRNHFASIRL*" /label="cotIC CDS" gene 2752131..2752499 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /label="cotIC gene" CDS complement(2752475..2753704) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /EC_number="3.1.4.52" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17153922, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17153922, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclic di-GMP phosphodiesterase" /protein_id="NP_391052.1" /db_xref="EnsemblGenomes-Gn:BSU31740" /db_xref="EnsemblGenomes-Tr:CAB15162" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR013976" /db_xref="InterPro:IPR014408" /db_xref="InterPro:IPR035919" /db_xref="SubtiList:BG10377" /db_xref="UniProtKB/Swiss-Prot:P14203" /translation="MRVFVARQPIFNRKEQVVAYELLYRESEENVYSAKDGDQATTDL VINSFLNIGIEKLTEGKRCFVNFTESLMFSNLPTSFNPKQLVIEILEDIPITPALISR CKELKKMGYMLALDDFYAINPQDEDLLEKLMSYIDILKIDFLKTTRMERRTILQTYGC RGLIFLAEKVETRKEYKQAVQDGFQLFQGYFFSEPRIISGHDLSTHFYSYYELLNELS KEQPNIKRVTEYIERDLSLSYQILKFLNSSHSRLSQKIESIQQAIMLLGFNEIKRWIY ILSFKDLSRKGHSSKHEIIKISLIRAKLCELLARKTSRPQPASYMLIGMFSLIDTLLH REIEEIVQELPLKDEVGQALLGHQNDYYQMLELVKLIESNNWDTCSELGNQLDKEEAY ECYLEALEWCHNLMDAK*" /label="pdeH CDS" gene complement(2752475..2753704) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /label="pdeH gene" S_feature 2752500..2753813 /Source="Nicolas_S_feature" /locus_tag="new_3258062_3259375" /HighExp="S4, S5, S3, S6, LoTm, S8, S7, T5.0H, B36, Pyr" /AntisenseName="yuxH" /AntisenseCor="-0.78363066752642896" /AntisenseRegPval="-56.4" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1218" promotor_-10 complement(2753739..2753758) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2753758) /Source="Nicolas_upshifts" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="upshifts" downshifts 2753771 /Source="Nicolas_upshifts" /id="D1641" /incds=0 /nref=6 /ntot=30 /MaxReadThrough="1.76106" /MaxDrop="4.58543" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2753773..2753780) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2753841..2755313) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /EC_number="6.3.4.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4296374, 12682299, 16199587, 24564896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate phosphoribosyltransferase" /protein_id="NP_391053.1" /db_xref="EnsemblGenomes-Gn:BSU31750" /db_xref="EnsemblGenomes-Tr:CAB15163" /db_xref="GOA:O32090" /db_xref="InterPro:IPR006405" /db_xref="InterPro:IPR007229" /db_xref="InterPro:IPR036068" /db_xref="SubtiList:BG13966" /db_xref="UniProtKB/Swiss-Prot:O32090" /translation="MLEYGFKDDSLSLHTDLYQINMAETYWRDGIHEKKAIFELFFRR LPFENGYAVFAGLEKAIEYLENFKFTDSDLSYLQDELGYHEDFIEYLRGLSFTGSLYS MKEGELVFNNEPIMRVEAPLVEAQLIETALLNIVNYQTLIATKAARIKGVIGDEVALE FGTRRAHEMDAAMWGARAALIGGFSATSNVRAGKRFNIPVSGTHAHALVQAYRDEYTA FKKYAETHKDCVFLVDTYDTLRSGMPNAIRVAKEFGDRINFIGIRLDSGDLAYLSKKA RKMLDEAGFTDAKVIASSDLDEHTIMNLKAQGARIDVWGVGTKLITAYDQPALGAVYK LVAIEEDGKMVDTIKISSNPEKVTTPGRKKVYRIINQSNHHSEGDYIALYDEQVNDQK RLRMFHPVHTFISKFVTNFYAKDLHELIFEKGILCYQNPEISDIQQYVQDNLSLLWEE YKRISKPEEYPVDLSEDCWSNKMQRIHEVKSRIEEELEEE*" /label="pncB CDS" gene complement(2753841..2755313) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /label="pncB gene" downshifts complement(2753851) /Source="Nicolas_upshifts" /id="D1642" /incds=0 /nref=200 /ntot=267 /MaxReadThrough="4.08676" /MaxDrop="6.72747" /score="16.2382739" /energy="-14.5" /TU="NA" /idTUdmin="U2475" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" misc_feature 2755194..2755198 /Source="Nicolas_upshift_promotors" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2755201 /Source="Nicolas_upshifts" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2755311 /Source="Nicolas_upshifts" /id="D1643" /incds=0 /nref=1 /ntot=123 /MaxReadThrough="1.2059" /MaxDrop="3.08208" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS complement(2755329..2755880) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /EC_number="3.5.1.19" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15135535, 17382284, 18616465, 24340054, 24512664; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinamidase; NAD salvage pathway" /protein_id="NP_391054.1" /db_xref="EnsemblGenomes-Gn:BSU31760" /db_xref="EnsemblGenomes-Tr:CAB15164" /db_xref="GOA:O32091" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG13965" /db_xref="UniProtKB/Swiss-Prot:O32091" /translation="MKKALICIDYTNDFVASDGKLTCGEPGRMIEEAIVNLTKEFITN GDYVVLAVDSHDEGDQYHPETRLFPPHNIKGTEGKDLYGKLLPLYQKHEHEPNVYYME KTRYSAFAGTDLELKLRERQIGELHLAGVCTDICVLHTAVDAYNKGFRIVVHKQAVAS FNQEGHAWALSHFANSIGAQVAE*" /label="pncA CDS" gene complement(2755329..2755880) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /label="pncA gene" promotor_-10 complement(2755902..2755921) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2755915) /Source="Nicolas_upshifts" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2755934..2755941) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2755977..2756375) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391055.1" /db_xref="EnsemblGenomes-Gn:BSU31770" /db_xref="EnsemblGenomes-Tr:CAB15165" /db_xref="InterPro:IPR012543" /db_xref="InterPro:IPR029064" /db_xref="PDB:2OHW" /db_xref="SubtiList:BG13964" /db_xref="UniProtKB/Swiss-Prot:O32092" /translation="MSEDKMDLYLQQGMYGPLETKPDERHLFLGSLRERVVLALTKGQ VLRSKPYKEAEHELKNSHNVTLLINGELQYQSYSSYIQMASRYGVPFKIVSDLQFHTP LGIVIAADIAVNRELIYIQDDIYNRSVLKS*" /label="yueI CDS" gene complement(2755977..2756375) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /label="yueI gene" S_feature complement(2756376..2756446) /Source="Nicolas_S_feature" /locus_tag="new_3261938_3262008_c" /HighExp="Etha, dia5, Diami, dia15, H2O2, LBGtran, LPhT, G135, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1219" CDS complement(2756447..2756695) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391056.1" /db_xref="EnsemblGenomes-Gn:BSU31780" /db_xref="EnsemblGenomes-Tr:CAB15166" /db_xref="InterPro:IPR020260" /db_xref="SubtiList:BG13963" /db_xref="UniProtKB/Swiss-Prot:O32093" /translation="MKIRKANINTQTGMITDVYLHENRKELRTLVAVPQLEWSTIISY EEDKATLPERLEASLRRHTEETPAGELAKKIIHWVTEM*" /label="yueH CDS" gene complement(2756447..2756695) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /label="yueH gene" promotor_-10 complement(2756718..2756737) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2756729) /Source="Nicolas_upshifts" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2756753..2756756) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2756768..2756989) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_391057.1" /db_xref="EnsemblGenomes-Gn:BSU31790" /db_xref="EnsemblGenomes-Tr:CAB15167" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13962" /db_xref="UniProtKB/Swiss-Prot:O32094" /translation="MPAIVGPIYIMSVTDNAAASFGDVFAISPKSVAHSGAGSGTFQL GDFVKINNQTSKTLFKDADITDETVSFNG*" /label="yueG CDS" gene complement(2756768..2756989) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /label="yueG gene" downshifts complement(2756795) /Source="Nicolas_upshifts" /id="D1644" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="3.65047" /MaxDrop="4.3681" /score="19.032155" /energy="-12.6" /TU="U2477,U2479,U2482" /idTUdmin="U2482" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2756983 /Source="Nicolas_upshifts" /id="D1645" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="1.17049" /MaxDrop="3.0193" /score="-7.47675224" /energy="-6.7" /TU="NA" /idTUdmin="U2480" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2757007..2757026) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2757013) /Source="Nicolas_upshifts" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2757039..2757048) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2757049..2758158) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391058.1" /db_xref="EnsemblGenomes-Gn:BSU31800" /db_xref="EnsemblGenomes-Tr:CAB15168" /db_xref="GOA:O32095" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13961" /db_xref="UniProtKB/Swiss-Prot:O32095" /translation="MLKSKVHFWTLQILFVLLIIFVATKVSFVFQPFIVFISTLFFPM LIAGILYFIFNPVVRLLEKKIPRTLSILLIYLLFIGLLAFISASVGPIITAQVTGLFN NLPDYIKQIQALTKDLSHSQWFTWMMNQDYVSISKIEQSLTSFLQNLPQNITSSLSAV FGVVTNITLVIITVPFILFYMLKDGHRFPHLAVKILPASYRTEGLKIFKDLSDTLAAY FQGQLLICLFVGTACFIGYLIAGLPYALILGIVMAITNIIPYVGPFLGAAPAVIVGFM DSPAKALFAIIVVVIVQQLDGNLLSPLVIGKRLNTHPLTIILLLIGAGSFGGILGMIL AVPVYAVVKAFFLNIVRLIKLRQRSRLEENAKPAE*" /label="yueF CDS" gene complement(2757049..2758158) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /label="yueF gene" promotor_-35 2757810..2757817 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2757832..2757851 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2757841..2758235 /Source="Nicolas_S_feature" /locus_tag="new_3263403_3263797" /HighExp="dia15, S8, H2O2, dia5, LBGstat, Paraq, C30, S7, Diami, G180" /AntisenseName="yueF" /AntisenseCor="0.28555063485711402" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1220" upshifts 2757841 /Source="Nicolas_upshifts" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2758206..2758225) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-10" upshifts complement(2758222) /Source="Nicolas_upshifts" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="upshifts" S_feature complement(2758224..2758664) /Source="Nicolas_S_feature" /locus_tag="new_3263786_3264226_c" /HighExp="Diami, S8, H2O2, S7, C90, Paraq, Salt, S1, dia15, dia5" /AntisenseName="yuzE" /AntisenseCor="0.47136608606324898" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1221" promotor_-35 2758227..2758229 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2758237 /Source="Nicolas_upshifts" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2758239..2758244) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-35" promotor_-10 2758245..2758264 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2758273..2758662 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391059.1" /db_xref="EnsemblGenomes-Gn:BSU31810" /db_xref="EnsemblGenomes-Tr:CAB15169" /db_xref="InterPro:IPR016789" /db_xref="InterPro:IPR019270" /db_xref="SubtiList:BG14054" /db_xref="UniProtKB/Swiss-Prot:O32096" /translation="MKAVTYDTDSELAYIYVLPPKKNRNVRTEELRVNDCLLLDISQD GKIAGFECFGEAAHLCAPFAGKSRLYVKDSDGYHFRVCQHASVRSCYTVYRVTFCFSD GDYQEFAGFDLDGTMYHSAFLQRLTEK*" /label="yuzE CDS" gene 2758273..2758662 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /label="yuzE gene" CDS complement(2758703..2758939) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391060.1" /db_xref="EnsemblGenomes-Gn:BSU31820" /db_xref="EnsemblGenomes-Tr:CAB15170" /db_xref="InterPro:IPR020139" /db_xref="SubtiList:BG14055" /db_xref="UniProtKB/Swiss-Prot:O32097" /translation="MVNQGSPQLVSLVDPYVYQTIKKLIGSRFVIQTVRDTVRGRLID VKPDHITIEGARNSVCLIRIQHMISVTPDYSERV*" /label="yuzF CDS" gene complement(2758703..2758939) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /label="yuzF gene" downshifts complement(2758709) /Source="Nicolas_upshifts" /id="D1646" /incds=0 /nref=12 /ntot=37 /MaxReadThrough="5.19136" /MaxDrop="5.1675" /score="30.7642328" /energy="-9.9" /TU="U2482" /idTUdmin="U2481" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2758959..2758978) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2758973) /Source="Nicolas_upshifts" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2758975..2759115) /Source="Nicolas_S_feature" /locus_tag="new_3264537_3264677_c" /HighExp="BT, Diami, S8, Etha, Sw, C90, Salt, B36, LPhT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.998, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1222" promotor_-35 complement(2758992..2759001) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2759116..2759646) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /EC_number="3.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_391061.1" /db_xref="EnsemblGenomes-Gn:BSU31830" /db_xref="EnsemblGenomes-Tr:CAB15171" /db_xref="GOA:O32098" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="SubtiList:BG13960" /db_xref="UniProtKB/Swiss-Prot:O32098" /translation="MRKVTLMDVFTHPIAQKYLQRSGVAHAIACAYHAYRLSVKADIN PDLAAKAALLHDIGHYEWYTDGKWDYEKYKRNDIHAIKGAERAHKLLIRLGEEPKAAK EIALAILLHTDSYLPEGELDKNTLQQIVKKADELDEEPGGHHHYRQIDPSTARKKIEK LDQLIDQAQASVIKPV*" /label="yueE CDS" gene complement(2759116..2759646) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /label="yueE gene" promotor_-10 complement(2759666..2759685) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-10" upshifts complement(2759677) /Source="Nicolas_upshifts" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="upshifts" S_feature complement(2759679..2759765) /Source="Nicolas_S_feature" /locus_tag="new_3265241_3265327_c" /HighExp="BT, S8, S6, S7, B36, Etha, S5, S4, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1223" promotor_-35 complement(2759697..2759705) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-35" promotor_-10 complement(2759760..2759779) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2759767) /Source="Nicolas_upshifts" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2759793..2759802) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2759844..2760575) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /EC_number="1.1.1.320" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11745140, 21670841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="benzil reductase (benzoin forming)" /protein_id="NP_391062.1" /db_xref="EnsemblGenomes-Gn:BSU31840" /db_xref="EnsemblGenomes-Tr:CAB15172" /db_xref="GOA:O32099" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13959" /db_xref="UniProtKB/Swiss-Prot:O32099" /translation="MELYIITGASKGLGQAIALQALEKGHEVHALSRTKTDVSHKKLT QHQIDLINLEEAEQQFETLLSSIDSDRYSGITLINNAGMVTPIKRAGEASLDELQRHY QLNLTAPVLLSQLFTKRFASYSGKKTVVNITSGAAKNPYKGWSAYCSSKAGLDMFTRT FGFEQEDEELPVNMISFSPGVMDTEMQAVIRSSSKKDFHHIERFRKLNETGSLRSPDF IAGTLLSLLEKGTENGRIYDIKEFL*" /label="bznD CDS" gene complement(2759844..2760575) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /label="bznD gene" downshifts complement(2759874) /Source="Nicolas_upshifts" /id="D1647" /incds=0 /nref=183 /ntot=253 /MaxReadThrough="2.76356" /MaxDrop="5.18507" /score="30.7642328" /energy="-9.9" /TU="NA" /idTUdmin="U2484" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2760590..2760609) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2760601) /Source="Nicolas_upshifts" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2760624..2760631) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2760638..2761093) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YueC protein" /protein_id="NP_391063.1" /db_xref="EnsemblGenomes-Gn:BSU31850" /db_xref="EnsemblGenomes-Tr:CAB15173" /db_xref="GOA:O32100" /db_xref="InterPro:IPR018920" /db_xref="InterPro:IPR020212" /db_xref="SubtiList:BG13958" /db_xref="UniProtKB/Swiss-Prot:O32100" /translation="MLSFSLFIPSAAAAQTEENTDVAPNQYEKKDIEIDTNYLHEDTY YEEKTELPEEQKDITFDKPKDKDAELIKDLFTSTNAEDSNTIAAQSKQLGITFAEKPM TKTSSTETEDEQETSSLLLPMIYVVLILLGIAGIVFLIPKVTAQENKKA*" /label="yueC CDS" gene complement(2760638..2761093) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /label="yueC gene" promotor_-35 2761046..2761052 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2761067..2761085 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2761075..2763442 /Source="Nicolas_S_feature" /locus_tag="new_3266637_3269004" /HighExp="Etha, Gly, Sw, Salt, LoTm, C30, BT, HiTm, Mal, G135" /AntisenseName="yueB" /AntisenseCor="-9.3455707286730305E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1224" upshifts 2761075 /Source="Nicolas_upshifts" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2761125..2764355) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022, 27179995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022, 27179995; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system; calcium-dependent phage SPP1 attachment site" /protein_id="NP_391064.1" /db_xref="EnsemblGenomes-Gn:BSU31860" /db_xref="EnsemblGenomes-Tr:CAB15174" /db_xref="GOA:O32101" /db_xref="InterPro:IPR023838" /db_xref="SubtiList:BG13957" /db_xref="UniProtKB/Swiss-Prot:O32101" /translation="MTEQRKSLIKLISAVIIILLLPVLFFRFIGDDPTKKAVNSTRQI AVVNEDTGVLSDEVKSDEEDKSAQFGKEVAAVLGERPDYSWTVVNRSAAETGLASKKY DAIVYIPSDFSKNILSYDKDHPQKATLEFSIQDNLNAVNKEKVQRELEDAQKTMNKKM SALYWNFVSQKVDNIRGEFDKIVNKESEFQNVMYNFYKPSSNDLAGEIKQQKDLIDEL KKSMNEAQGTTKEKASTAEEAKNTLKEFIDTVERYKEYQENQKKLLLAAQDSTQQQIR TGLDAIQAQQKANQFSERMSGLATGIGQAKTQIGLTNLALNNAEKLRQNQVPLQEMGM KKIENDMFNAFLSRYKSQYEAIKYQNLNQLQENIGKNRLSLLKPKESDEKEDGEDTSD NKDDTDKEDIEDIKLDLEKQRDELKNVATEIKDISEGLKEPEQEKPTTPDAEEPSTDD SPNTEEPSNDIPTSDDQPTNEDTGSSEEGTQDNGSQNDVQTNIETGQKHQESSKNVPE QDTNTENTGTSKTDFSLIELADENDGSNQSDGLQGDGADGETDISGAKKRLNEAAIKL EEIENALQEKQEEHNNKLEKHIDELNQEIKELNKTVSKLNDQIGDLTKKLVDFDNNVN DAYRLIYNLEDEIIQTLQSRGYIDQKEKLSSIFSSRIETDNISNLMKYYNSLNLYKST LNDNLDLGSLTIIKGEVIQEQDGNVQSVLALTPEESASWEALKNNTMQTDEDINSFID GMTKFADDYSGYIRDSQAGVLDELTKISESAAKASEQLVTGATQESATFSNDGLSGTM ALSVQDTVGQEVLQMSDMMGSLSDRQSGIIDYTTNMQQSVNDVQAKADTLNNNWGKNV ASTKLVRNDVYGILGNTLVDGQNNGYVYDYLANPLKISGEVPEEKIQTVPPVVILVIV LISSLLIGYFSSYYQNAPLLVKGALFGILNILVGLMISLFGLNIYSLPDDQTIKWSVF TILLLVASSAFIRTAFRFGSIPGWVASAAMILFYVAPLIDLIMPNFTFEDPVSKVYID IQYGTGHLFTMGITVLLIITVIAVALPLIIRLMAEHTAESDETYEA*" /label="yueB CDS" gene complement(2761125..2764355) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /label="yueB gene" CDS complement(2764352..2768839) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system FtsK/SpoIIIE family ATPase" /protein_id="NP_391066.2" /db_xref="EnsemblGenomes-Gn:BSU31875" /db_xref="EnsemblGenomes-Tr:CAB15176" /db_xref="GOA:C0SPA7" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR022206" /db_xref="InterPro:IPR023839" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12375" /db_xref="UniProtKB/Swiss-Prot:C0SPA7" /translation="MSLLWVFYQNNVQKLNLSNLPSSHPVTIGPDVKDSVTISTIPFN SGVISLKRKESGGQYEVFLGNDCLGTIETDISFTLQTDQQDIRLILTGSEPEKSVYFT GNRDEIVCSSEKTNADIYLNPQDFAFAEQSTFSLLRAGGSWSVRPESGTIFLNGEKIN ANTPLKPGDEIFWNFTQMRVTEQDLLEIVHYAQFETALTETVKPSTEMQKKYPQYRRT PRMVYDLPDDRVSFSFPSQESDQTNRGLWLVILPPLVMLIVMGVVAIIQPRGIFILVS LAMFMMTLITSTVQYFRDKNQRKKREEKRERVYKLYLDNKRKELQALAEKQKQVLEFH FPSFEQMKYLTSEISDRIWEKSLESKDYLQLRLGTGTVPSSYEINMSGGDLANRDIDD LMEKSQHMQRVYKDIRNAPVTVDLAEGPMGLVGKSQIVKNEIHQLIGQLSFFNSYHDL RFVFIFHEEEYKDWEWMKWLPQFQMPHIYAKGFIYNEQTRDQLLSSLYELIRERDLED DKEKLQFKPHFVFVITNQQLISEHVILEYLEGQHEHLGISTIVAAETKESLSENITTL VRYINEHEGDILIQKKKAVRIPFRLDHHQREDNERFSRTLRTLNHQVGITNSIPETVS FLELFHAKEVKEIGIQQRWLTSESSKSLSVPIGYKGKDDIVYLNLHEKAHGPHGLLAG TTGSGKSEFLQTYILSLAVHFHPHEAAFLLIDYKGGGMAQPFRNIPHLLGTITNIEGS KNFSMRALASIKSELKKRQRLFDQYQVNHINDYTKLYKQGKAEVAMPHLFLISDEFAE LKSEEPDFIRELVSAARIGRSLGVHLILATQKPGGIIDDQIWSNSRFKVALKVQDATD SKEILKNSDAANITVTGRGYLQVGNNEVYELFQSAWSGAPYLEEVYGTEDEIAIVTDT GLIPLSEVDTEDNAKKDVQTEIEAVVDEIERIQDEMGIEKLPSPWLPPLAERIPRTLF PSNEKDHFHFAYVDEPDLQRQAPIAYKMMEDGNIGIFGSSGYGKSIAAATFLMSFADV YTPEELHVYIFDFGNGTLLPLAKLPHTADYFLMDQSRKIEKFMIRIKEEIDRRKRLFR EKEISHIKMYNALSEEELPFIFITIDNFDIVKDEMHELESEFVQLSRDGQSLGIYFML TATRVNAVRQSLLNNLKTKIVHYLMDQSEGYSIYGRPKFNLEPIPGRVIIQKEELYFA QMFLPVDADDDIGMFNELKSDVQKLQGRFASMEQPAPIPMLPESLSTRELSIRFKLER KPLSVPIGLHEETVSPVYFDLGKHKHCLILGQTQRGKTNVLKVMLEHLIDDETEMIGL FDSIDRGLSHYAKESDVSYLETKEDIEQWIETAEDIFKTREAMYVEAVRQGDAQNLRF SQVVLMIDGITRFQQTIDTRIQDRLANFMKSYAHLGFSFIPGGNHSEFSKGYDSLTTE MKQIRHAILLMKKSEQNVIPLPYQRQEPEIQPGFGYVVENGKEQKVQIPLCSAERESA R*" /label="yukAB CDS" gene complement(2764352..2768839) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /label="yukAB gene" promotor_-35 2768114..2768120 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2768135..2768153 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2768141..2769103 /Source="Nicolas_S_feature" /locus_tag="new_3273703_3274665" /HighExp="Etha, Sw, Gly, Salt, B60, M9-stat, LoTm, T0.30H, BT, LPhT" /AntisenseName="yukB" /AntisenseCor="-0.26212584196591598" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1225" upshifts 2768141 /Source="Nicolas_upshifts" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2768900..2770255) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /function="11.1: Protein and peptide secretion and trafficking" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukC protein" /protein_id="NP_391067.1" /db_xref="EnsemblGenomes-Gn:BSU31890" /db_xref="EnsemblGenomes-Tr:CAB15177" /db_xref="GOA:P71070" /db_xref="InterPro:IPR018778" /db_xref="SubtiList:BG12376" /db_xref="UniProtKB/Swiss-Prot:P71070" /translation="MSGEQKSYLENQLEAVAEKTDAGYTFTFQREKIKLLDGLEANVI KDINPFFHKEIDVTDDEVIITIQPPSSYKAFRFMKAKDKKSKWQFAYQLVQAVQQHNL SRLNLIVAPENIVFDKGLTPYFLHYGVKESIPPYERDEERVWQELKAAAALAVDGAFA FEDYLKFNETLTFSAEAKAILDAESYDDLLELIQTHIDELEAKAKTYIHIPRKKWNIQ RYIGLGLIVLLVPALIYSMYALFFAQPKHQAIVDSNRAFLNKQYSEVISTLSKYDAES LPESVQYQLATSYVEVENLGSAKTKNIENNLVTLQSDPQHFLYWIDYGRGEYKEAISI GRKLEYNDYIYFALAKYKQQLLSEDTNDEDIQKELDSVNSELEKAQKERQENKQSNSE TSLVDTSEEQTQTDEEKQAEEKAAEEKAAAEEKAKKEEQKEKEDEKKETEKKDEKKDD K*" /label="yukC CDS" gene complement(2768900..2770255) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /label="yukC gene" downshifts complement(2768921) /Source="Nicolas_upshifts" /id="D1648" /incds=0 /nref=5 /ntot=116 /MaxReadThrough="6.33518" /MaxDrop="3.1562" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=5823 /isTUend="FALSE" /label="downshifts" CDS complement(2770270..2770509) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /function="11.1: Protein and peptide secretion and trafficking" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukD protein" /protein_id="NP_391068.1" /db_xref="EnsemblGenomes-Gn:BSU31900" /db_xref="EnsemblGenomes-Tr:CAB15178" /db_xref="InterPro:IPR014921" /db_xref="InterPro:IPR024962" /db_xref="InterPro:IPR029071" /db_xref="PDB:2BPS" /db_xref="SubtiList:BG12377" /db_xref="UniProtKB/Swiss-Prot:P71071" /translation="MYIDITIDLKHYNGSVFDLRLSDYHPVKKVIDIAWQAQSVSMPP REGHWIRVVNKDKVFSGECKLSDCGITNGDRLEIL*" /label="yukD CDS" gene complement(2770270..2770509) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /label="yukD gene" CDS complement(2770579..2770872) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:11973144, 15576783, 22720735, 24798022, 24828531" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11973144, 15576783, 22720735, 24798022, 24828531; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small WGX100 secreted protein (ESX-dependent secretion)" /protein_id="NP_391069.2" /db_xref="EnsemblGenomes-Gn:BSU31910" /db_xref="EnsemblGenomes-Tr:CAB15179" /db_xref="GOA:C0SP85" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12378" /db_xref="UniProtKB/Swiss-Prot:C0SP85" /translation="MAGLIRVTPEELRAMAKQYGVESQEVLNQVDRLNRMISDLKSMW EGASSEAFADQYEQLKPSFIKMSDLLQDVNQQLDQTANTLESTDQDIANQIRG*" /label="yukE CDS" gene complement(2770579..2770872) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /label="yukE gene" downshifts complement(2770589) /Source="Nicolas_upshifts" /id="D1649" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="6.21938" /MaxDrop="7.50121" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=4155 /isTUend="FALSE" /label="downshifts" downshifts 2770866 /Source="Nicolas_upshifts" /id="D1650" /incds=0 /nref=1 /ntot=26 /MaxReadThrough="2.85718" /MaxDrop="3.33739" /score="43.0917981" /energy="-17.1" /TU="NA" /idTUdmin="U2487" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" S_feature complement(2770873..2770951) /Source="Nicolas_S_feature" /locus_tag="new_3276435_3276513_c" /HighExp="T-1.10H, T1.0H, T-0.40H, T1.30H, BI, T2.30H, T3.0H, T-2.40H, T2.0H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1226" promotor_-35 2770914..2770921 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2770931..2770950) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2770932 /Source="Nicolas_upshifts" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2770936..2770953 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2770951) /Source="Nicolas_upshifts" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2770965..2770972) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2771010..2771015 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2771030..2771049 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2771042..2771148 /Source="Nicolas_S_feature" /locus_tag="new_3276604_3276710" /HighExp="S8, C30, S7, S6, Pyr, Glucon, B60, LoTm, C90, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="0.523, 0.76" /TUlongSig="NA" /TUlongPSig="NA" /label="S1227" upshifts 2771042 /Source="Nicolas_upshifts" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2771217..2771223 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2771237..2771256 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2771240 /Source="Nicolas_upshifts" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2771345..2771348 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-35" upshifts 2771357 /Source="Nicolas_upshifts" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="upshifts" promotor_-10 complement(2771360..2771379) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2771364..2771383 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-10" upshifts complement(2771382) /Source="Nicolas_upshifts" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2771393..2772661 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22797752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22797752; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AdeR-alanine)" /protein_id="NP_391070.2" /db_xref="EnsemblGenomes-Gn:BSU31920" /db_xref="EnsemblGenomes-Tr:CAB15180" /db_xref="GOA:P71073" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12379" /db_xref="UniProtKB/Swiss-Prot:P71073" /translation="MSKRNQARKVGRFMTMPNDPFKYSFDRLEDVADHISDVLRCPIT IEDVNHKLLAYSTHSDCTDPARTSTIIGRRVPEKVINKLWKDGTIPALLKTDQPIRVK QIDEVGLSNRVAISIWKNKQVLGFIWALEIQKTLSDEDLLTLQMAAKAVKNKLLKLQI RKTKNEERSQEFFWKMLTGHIHQEDDMADGFHKLGMAAPSEFSVMIIRINGELTEKIE QQLQYLQETTQQVYVLLATVDSNELIILTSPKTDHPFQDLKQFALSTQKQLKERYKIE DVSIAFGGIYNSISFVSRSYQEALSVLKTKERFAEETKHLFSFSELGIYQYLDVLNEK RKQAGHYNYSLSKLEQYDRDHQSNMVETLERFIEADSNVNTASKLLNIHVNTLNYRLK RISQIAEIDLKNVNQKFTIYLDIKLRHMDL*" /label="adeR CDS" gene 2771393..2772661 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /label="adeR gene" promotor_-35 complement(2771394..2771401) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2772721..2772740 /Source="Nicolas_upshift_promotors" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2772726 /Source="Nicolas_upshifts" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2772763..2773899 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /EC_number="1.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:488097, 8226620, 22720735, 22797752, 26202482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 488097, 8226620, 22720735, 22797752, 26202482; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-alanine dehydrogenase (NAD-dependent)" /protein_id="NP_391071.1" /db_xref="EnsemblGenomes-Gn:BSU31930" /db_xref="EnsemblGenomes-Tr:CAB15181" /db_xref="GOA:Q08352" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR007886" /db_xref="InterPro:IPR008141" /db_xref="InterPro:IPR008142" /db_xref="InterPro:IPR008143" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10468" /db_xref="UniProtKB/Swiss-Prot:Q08352" /translation="MIIGVPKEIKNNENRVALTPGGVSQLISNGHRVLVETGAGLGSG FENEAYESAGAEIIADPKQVWDAEMVMKVKEPLPEEYVYFRKGLVLFTYLHLAAEPEL AQALKDKGVTAIAYETVSEGRTLPLLTPMSEVAGRMAAQIGAQFLEKPKGGKGILLAG VPGVSRGKVTIIGGGVVGTNAAKMAVGLGADVTIIDLNADRLRQLDDIFGHQIKTLIS NPVNIADAVAEADLLICAVLIPGAKAPTLVTEEMVKQMKPGSVIVDVAIDQGGIVETV DHITTHDQPTYEKHGVVHYAVANMPGAVPRTSTIALTNVTVPYALQIANKGAVKALAD NTALRAGLNTANGHVTYEAVARDLGYEYVPAEKALQDESSVAGA*" /label="ald CDS" gene 2772763..2773899 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /label="ald gene" downshifts 2773899 /Source="Nicolas_upshifts" /id="D1651" /incds=0 /nref=42 /ntot=190 /MaxReadThrough="5.86626" /MaxDrop="4.4689" /score="41.2794059" /energy="-14.2" /TU="U2493" /idTUdmin="U2493" /TUdmin="-769" /isTUend="FALSE" /label="downshifts" promotor_-35 2773948..2773956 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2773966 /Source="Nicolas_upshifts" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2773968..2773986 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2774011..2774688 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391073.2" /db_xref="EnsemblGenomes-Gn:BSU31945" /db_xref="EnsemblGenomes-Tr:CAB15183" /db_xref="InterPro:IPR019268" /db_xref="SubtiList:BG12380" /db_xref="UniProtKB/Swiss-Prot:C0SPB1" /translation="MAVQQYGVLKGIVLDMKRETDDDSPHFQVKMLGEENTYYRCAIN VMSSSEESEVLYLADDQFDSGSITILPNMPYGYTRINEANREVALDYVRGNLFDPREM KPLPHEITGPDNDLNDFIETYMKKAQDEKTPVYIFGSKFGPEQAADKIFGFTPTNGMH NIHMNQGNAMDTRWKKDNGSWHDGGILIQFADQWAAVFLAFLSQSWCTDENGNPVRDC DHTQTSA*" /label="yukJ CDS" gene 2774011..2774688 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /label="yukJ gene" downshifts 2774672 /Source="Nicolas_upshifts" /id="D1652" /incds=0 /nref=37 /ntot=185 /MaxReadThrough="3.39608" /MaxDrop="5.40829" /score="9.49891506" /energy="-12" /TU="U2494" /idTUdmin="U2493" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2774732..2774941) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11112781, 20845982, 21890635, 24975514, 28880538; Product type r: regulator" /codon_start=1 /transl_table=11 /product="stimulator of DhbF tyrosine adenylation activity" /protein_id="YP_003097779.1" /db_xref="EnsemblGenomes-Gn:BSU31959" /db_xref="EnsemblGenomes-Tr:CAX52685" /db_xref="InterPro:IPR005153" /db_xref="UniProtKB/Swiss-Prot:C0H3Q6" /translation="MANPFENADGTYLVLVNEEGQYSLWPGFIDVPSGWTVVHEQKGR EACLDYIQSHWSDMRPNSLKTVENV*" /label="mbtH CDS" gene complement(2774732..2774941) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /label="mbtH gene" downshifts complement(2774744) /Source="Nicolas_upshifts" /id="D1653" /incds=0 /nref=106 /ntot=174 /MaxReadThrough="1.39981" /MaxDrop="6.23998" /score="17.380299" /energy="-12" /TU="NA" /idTUdmin="U2496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2774957..2782093) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /EC_number="2.7.7.-" /EC_number="5.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11112781, 12354229, 16672620, 18957859, 26284661, 27731335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11112781, 12354229, 16672620, 18957859, 26284661, 27731335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin synthetase" /protein_id="NP_391076.3" /db_xref="EnsemblGenomes-Gn:BSU31960" /db_xref="EnsemblGenomes-Tr:CAB15186" /db_xref="GOA:P45745" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11243" /db_xref="UniProtKB/Swiss-Prot:P45745" /translation="MPDTKDLQYSLTGAQTGIWFAQQLDPDNPIYNTAEYIEINGPVN IALFEEALRHVIKEAESLHVRFGENMDGPWQMINPSPDVQLHVIDVSSEPDPEKTALN WMKADLAKPVDLGYAPLFNEALFIAGPDRFFWYQRIHHIAIDGFGFSLIAQRVASTYT ALIKGQTAKSRSFGSLQAILEEDTDYRGSEQYEKDRQFWLDRFADAPEVVSLADRAPR TSNSFLRHTAYLPPSDVNALKEAARYFSGSWHEVMIAVSAVYVHRMTGSEDVVLGLPM MGRIGSASLNVPAMVMNLLPLRLTVSSSMSFSELIQQISREIRSIRRHHKYRHEELRR DLKLIGENHRLFGPQINLMPFDYGLDFAGVRGTTHNLSAGPVDDLSINVYDRTDGSGL RIDVDANPEVYSESDIKLHQQRILQLLQTASAGEDMLIGQMELLLPEEKEKVISKWNE TAKSEKLVSLQDMFEKQAVLTPERIALMCDDIQVNYRKLNEEANRLARLLIEKGIGPE QFVALALPRSPEMVASMLGVLKTGAAYLPLDPEFPADRISYMLEDAKPSCIITTEEIA ASLPDDLAVPELVLDQAVTQEIIKRYSPENQDVSVSLDHPAYIIYTSGSTGRPKGVVV TQKSLSNFLLSMQEAFSLGEEDRLLAVTTVAFDISALELYLPLISGAQIVIAKKETIR EPQALAQMIENFDINIMQATPTLWHALVTSEPEKLRGLRVLVGGEALPSGLLQELQDL HCSVTNLYGPTETTIWSAAAFLEEGLKGVPPIGKPIWNTQVYVLDNGLQPVPPGVVGE LYIAGTGLARGYFHRPDLTAERFVADPYGPPGTRMYRTGDQARWRADGSLDYIGRADH QIKIRGFRIELGEIDAVLANHPHIEQAAVVVREDQPGDKRLAAYVVADAAIDTAELRR YMGASLPDYMVPSAFVEMDELPLTPNGKLDRKALPAPDFSTSVSDRAPRTPQEEILCD LFAEVLGLARVGIDDSFFELGGHSLLAARLMSRIREVMGAELGIAKLFDEPTVAGLAA HLDLAQSACPALQRAERPEKIPLSFAQRRLWFLHCLEGPSPTYNIPVAVRLSGELDQG LLKAALYDLVCRHESLRTIFPESQGTSYQHILDADRACPELHVTEIAEKELSDRLAEA VRYSFDLAAEPAFRAELFVIGPDEYVLLLLVHHIVGDGWSLTPLTRDLGTAYAARCHG RSPEWAPLAVQYADYALWQQELLGNEDDPNSLIAGQLAFWKETLKNLPDQLELPTDYS RPAEPSHDGDTIHFRIEPEFHKRLQELARANRVSLFMVLQSGLAALLTRLGAGTDIPI GSPIAGRNDDALGDLVGLFINTLVLRTDTSGDPSFRELLDRVREVNLAAYDNQDLPFE RLVEVLNPARSRATHPLFQIMLAFQNTPDAELHLPDMESSLRINSVGSAKFDLTLEIS EDRLADGTPNGMEGLLEYSTDLFKRETAQALADRLMRLLEAAESDPDEQIGNLDILAP EEHSSMVTDWQSVSEKIPHACLPEQFEKQAALRPDAIAVVYENQELSYAELNERANRL ARMMISEGVGPEQFVALALPRSLEMAVGLLAVLKAGAAYLPLDPDYPADRIAFMLKDA QPAFIMTNTKAANHIPPVENVPKIVLDDPELAEKLNTYPAGNPKNKDRTQPLSPLNTA YVIYTSGSTGVPKGVMIPHQNVTRLFAATEHWFRFSSGDIWTMFHSYAFDFSVWEIWG PLLHGGRLVIVPHHVSRSPEAFLRLLVKEGVTVLNQTPSAFYQFMQAEREQPDLGQAL SLRYVIFGGEALELSRLEDWYNRHPENRPQLINMYGITETTVHVSYIELDRSMAALRA NSLIGCGIPDLGVYVLDERLQPVPPGVAGELYVSGAGLARGYLGRPGLTSERFIADPF GPPGTRMYRTGDVARLRADGSLDYVGRADHQVKIRGFRIELGEIEAALVQHPQLEDAA VIVREDQPGDKRLAAYVIPSEETFDTAELRRYAAERLPDYMVPAAFVTMKELPLTPNG KLDRKALPAPDFAAAVTGRGPRTPQEEILCDLFMEVLHLPRVGIDDRFFDLGGHSLLA VQLMSRIREALGVELSIGNLFEAPTVAGLAERLEMGSSQSALDVLLPLRTSGDKPPLF CVHPAGGLSWCYAGLMTNIGTDYPIYGLQARGIGQREELPKTLDDMAADYIKQIRTVQ PKGPYHLLGWSLGGNVVQAMATQLQNQGEEVSLLVMLDAYPNHFLPIKEAPDDEEALI ALLALGGYDPDSLGEKPLDFEAAIEILRRDGSALASLDETVILNLKNTYVNSVGILGS YKPKTFRGNVLFFRSTIIPEWFDPIEPDSWKPYINGQIEQIDIDCRHKDLCQPEPLAQ IGKVLAVKLEELNK*" /label="dhbF CDS" gene complement(2774957..2782093) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /label="dhbF gene" CDS complement(2782113..2783051) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /EC_number="3.3.2.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismatase (siderophore specific)" /protein_id="NP_391077.1" /db_xref="EnsemblGenomes-Gn:BSU31970" /db_xref="EnsemblGenomes-Tr:CAB15187" /db_xref="GOA:P45743" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11241" /db_xref="UniProtKB/Swiss-Prot:P45743" /translation="MAIPAIQPYQMPTASDMPQNKVSWVPDPNRAVLLIHDMQNYFVD AFTAGASPVTELSANIRKLKNQCVQLGIPVVYTAQPGSQNPDDRALLTDFWGPGLNSG PYEEKIITELAPEDDDLVLTKWRYSAFKRTNLLEMMRKEGRDQLIITGIYAHIGCLVT ACEAFMEDIKAFFVGDAVADFSLEKHQMALEYAAGRCAFTVMTDSLLDQLQNAPADVQ KTSANTGKKNVFTCENIRKQIAELLQETPEDITDQEDLLDRGLDSVRIMTLVEQWRRE GAEVTFVELAERPTIEEWQKLLTTRSQQVLPNADYL*" /label="dhbB CDS" gene complement(2782113..2783051) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /label="dhbB gene" CDS complement(2783079..2784698) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /EC_number="2.7.7.58" /EC_number="6.3.2.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydroxybenzoate-AMP ligase" /protein_id="NP_391078.1" /db_xref="EnsemblGenomes-Gn:BSU31980" /db_xref="EnsemblGenomes-Tr:CAB15188" /db_xref="GOA:P40871" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR011963" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:1MD9" /db_xref="PDB:1MDB" /db_xref="PDB:1MDF" /db_xref="SubtiList:BG11020" /db_xref="UniProtKB/Swiss-Prot:P40871" /translation="MLKGFTPWPDELAETYRKNGCWAGETFGDLLRDRAAKYGDRIAI TCGNTHWSYRELDTRADRLAAGFQKLGIQQMDRVVVQLPNIKEFFEVIFALFRLGALP VFALPSHRSSEITYFCEFAEAAAYIIPDAYSGFDYRSLARQVQSKLPTLKNIIVAGEA EEFLPLEDLHAEPVKLPEVKSSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVC WLDHSTVYLAALPMAHNYPLSSPGVLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTIT ALVPPLAMVWMDAASSRRDDLSSLQVLQVGGAKFSAEAARRVKAVFGCTLQQVFGMAE GLVNYTRLDDPEEIIVNTQGKPMSPYDEMRVWDDHDRDVKPGETGHLLTRGPYTIRGY YKAEEHNAASFTEDGFYRTGDIVRLTRDGYIVVEGRAKDQINRGGEKVAAEEVENHLL AHPAVHDAAMVSMPDQFLGERSCVFIIPRDEAPKAAELKAFLRERGLAAYKIPDRVEF VESFPQTGVGKVSKKALREAISEKLLAGFKK*" /label="dhbE CDS" gene complement(2783079..2784698) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /label="dhbE gene" CDS complement(2784727..2785923) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /EC_number="5.4.4.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12354229, 16672620, 19777807, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismate synthase (siderophore-specific)" /protein_id="NP_391079.2" /db_xref="EnsemblGenomes-Gn:BSU31990" /db_xref="EnsemblGenomes-Tr:CAB15189" /db_xref="GOA:P45744" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="SubtiList:BG11242" /db_xref="UniProtKB/Swiss-Prot:P45744" /translation="MLDQNVITETKAEHLLHEYQPGAFFLASPHRVLLAKGICEIVPE ADGQNQMETLSGRIAEALRQAKQSGQSRPLVVGAVPFDQVKAARLVVPEEVRWSGPLQ FDHEEKEQQAGHTYHIKPVPEPEDYKNGVEQGLARIADGTLSKIVLSRSLHLTSPEPI QTDELLRHLAQHNSHGYTFAADVSSQEETSPRRTLLGASPELLVSRMGTQVVSNPLAG SRPRSNDPVEDQRRAAELLSSAKDLHEHAVVADAVAAALRPFCRTLEVPEKPSLIKTE TMWHLSSVIKGELSDPSVTALELAAALHPTPAVCGTPTDLAREAILSIEPFDRGFFTG MVGWCDDAGDGEWIVTIRCAEAEERSLRLYAGAGVVAGSKPEDELQETSAKFRTMLRA MGVDHI*" /label="dhbC CDS" gene complement(2784727..2785923) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /label="dhbC gene" promotor_-35 2785771..2785778 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2785793..2785812 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2785800 /Source="Nicolas_upshifts" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2785949..2786734) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /EC_number="1.3.1.28" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase" /protein_id="NP_391080.2" /db_xref="EnsemblGenomes-Gn:BSU32000" /db_xref="EnsemblGenomes-Tr:CAB15190" /db_xref="GOA:P39071" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR003560" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11019" /db_xref="UniProtKB/Swiss-Prot:P39071" /translation="MNAKGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEK LEKVVSSLKAEGRHAEAFPADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIH SLSDEEWEATFSVNSTGVFNASRSVSKYMMDRRSGSIVTVGSNAAGVPRTSMAAYASS KAAAVMFTKCLGLELAEYNIRCNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKT GIPLKKLAKPSDIADAVLFLVSGQAGHITMHNLCVDGGATLGV*" /label="dhbA CDS" gene complement(2785949..2786734) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /label="dhbA gene" S_feature complement(2786735..2786844) /Source="Nicolas_S_feature" /locus_tag="new_3292297_3292406_c" /HighExp="HiOs, GM 15, B60, nit, GM 10, GM 25, B36, GM 60, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1228" promotor_-10 complement(2786839..2786858) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2786844) /Source="Nicolas_upshifts" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2786846..2786927) /Source="Nicolas_S_feature" /locus_tag="new_3292408_3292489_c" /HighExp="HiOs, B60, nit, B36, GM 45, GM 10, BI, GM 15, GM 25, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1229" promotor_-35 complement(2786872..2786879) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2786928..2787797) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16889643, 19673474, 26284661, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillibactin trilactone hydrolase" /protein_id="NP_391081.2" /db_xref="EnsemblGenomes-Gn:BSU32010" /db_xref="EnsemblGenomes-Tr:CAB15191" /db_xref="GOA:O32102" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13974" /db_xref="UniProtKB/Swiss-Prot:O32102" /translation="MKEQTTDRTNGGTSNAFTIPGTEVRMMSSRNENRTYHIFISKPS TPPPPAGYPVIYLLDANSVFGTMTEAVRIQGRRPEKTGVIPAVIVGIGYETAEPFSSA RHRDFTMPTAQSKLPERPDGREWPEHGGAEGFFRFIEEDLKPEIERDYQIDKKRQTIF GHSLGGLFVLQVLLTKPDAFQTYIAGSPSIHWNKPFILKKTDHFVSLTKKNNQPINIL LAAGELEQHHKSRMNDNARELYERLAVLSEQGIRAEFCEFSGEGHISVLPVLVSRALR FALHPDGPHLSMG*" /label="besA CDS" gene complement(2786928..2787797) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /label="besA gene" S_feature complement(2787798..2787878) /Source="Nicolas_S_feature" /locus_tag="new_3293360_3293440_c" /HighExp="HiOs, B60, nit, GM 15, BI, B36, LoTm, T-5.40H, Lbexp, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1230" promotor_-10 complement(2787862..2787881) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2787878) /Source="Nicolas_upshifts" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2787895..2787902) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2788011..2788607) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /EC_number="1.7.3.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11598126, 16341843, 21190336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin containing enzyme subunit" /protein_id="NP_391082.1" /db_xref="EnsemblGenomes-Gn:BSU32020" /db_xref="EnsemblGenomes-Tr:CAB15192" /db_xref="GOA:O32103" /db_xref="InterPro:IPR000572" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13973" /db_xref="UniProtKB/Swiss-Prot:O32103" /translation="MYFGKTRQSDQSGRVPPNQNVTTSFPVLHTGDVPYYEDMTKWNL QVYGLVDHPMLLSFEDVKAFPRYESKNDIHCVTGWSRLDNVWQGVRACDIAEKAGVKE EAGYVILHAEEGWTTNLPLDDFLAETSLLAYAHNGEPLTPEHGFPLRGVFPHLYFWKS AKWLRGIQFTKENHPGFWERNGYHMRGDPWQNQRFTWD*" /label="yuiH CDS" gene complement(2788011..2788607) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /label="yuiH gene" S_feature complement(2788608..2788692) /Source="Nicolas_S_feature" /locus_tag="new_3294170_3294254_c" /HighExp="H2O2, Paraq, Cold, dia15, G135, B36, G180, B60, LoTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.204" /TUlongSig="NA" /TUlongPSig="NA" /label="S1231" promotor_-35 2788643..2788650 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2788660 /Source="Nicolas_upshifts" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2788665..2788684 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2788686..2788700) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2788692) /Source="Nicolas_upshifts" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2788708..2788712) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2788708..2789310 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717296, 15849754, 16850406, 24816803; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative biotin transporter" /protein_id="NP_391083.1" /db_xref="EnsemblGenomes-Gn:BSU32030" /db_xref="EnsemblGenomes-Tr:CAB15193" /db_xref="GOA:O32104" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13972" /db_xref="UniProtKB/Swiss-Prot:O32104" /translation="MKQRKLRAGDMALIGMFAALMAVGANITSVAPFLQVAGIPLSMQ PFFCLLAALLLGSKRAAIAMIVYALVGLAGAPVFAQFSAGFAPFAGKSGGFIISYIPA AFAAGWFLERNIQPSKIRFLIASLIGTAIMYLIGTTYMYLALKLWIHTPVSYGTAWGF MIWFMVKDTALAVILSFIAPAIYRSIHKATGFNRNHISST*" /label="bioYB CDS" gene 2788708..2789310 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /label="bioYB gene" downshifts 2789296 /Source="Nicolas_upshifts" /id="D1654" /incds=0 /nref=145 /ntot=206 /MaxReadThrough="3.24182" /MaxDrop="6.72885" /score="12.6395055" /energy="-6.3" /TU="U2498" /idTUdmin="U2498" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" CDS complement(2789380..2790708) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15135544, 15849754, 16850406, 23504016; Product type t : transporter" /codon_start=1 /transl_table=11 /product="histidine / basic amino acid transporter" /protein_id="NP_391084.1" /db_xref="EnsemblGenomes-Gn:BSU32040" /db_xref="EnsemblGenomes-Tr:CAB15194" /db_xref="GOA:O32105" /db_xref="InterPro:IPR018461" /db_xref="InterPro:IPR032813" /db_xref="SubtiList:BG13971" /db_xref="UniProtKB/Swiss-Prot:O32105" /translation="MNAVVIAVLLMLVLSLLRVNIVIALIIGALAGGLTGGLGLGETV KAFTDGLGGNATVAVSYAMLGAFAAALTKTGLPDAMVEASVKLIGNKEDSRKKALSKV LIVLIILIVSCFSQNVVPVHIAFIPVLIPPLLKIFNELEMDRRLIACVITFGLTAPYI LLPVGFGQIFQGMLKDNMADAGLNVPLADIPYALIIPVAGMVVGLILSVIVYRKPKQY ETKDISGAEASPYTRKSIGIAVLAIVVSLGVQLYLSQTLGVEGMIMGALAGLIVLFVS GVMKRDEADSLITDGMVLMAFIGFVMLVAAGFSNVLTKTGDVESLVKTSAGFIGHSQS LGALLMLIVGLLITMGIGSSFATIPVITTIFVPLCMQLGFSPMATIAIIGAAAALGDA GSPASDSTLGPTSGLSADGQHHHIWDTCVPTFIFYNIPLVIFGWIAALVL*" /label="hisP CDS" gene complement(2789380..2790708) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /label="hisP gene" downshifts complement(2789396) /Source="Nicolas_upshifts" /id="D1655" /incds=0 /nref=14 /ntot=114 /MaxReadThrough="4.26298" /MaxDrop="4.37949" /score="18.6861113" /energy="-15.4" /TU="U2500" /idTUdmin="U2500" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2790762..2790781) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2790765) /Source="Nicolas_upshifts" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2790796..2790803) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2790855..2792357) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /EC_number="3.4.11.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8057849, 9864319, 10449417, 26936797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytosol aminopeptidase" /protein_id="NP_391085.1" /db_xref="EnsemblGenomes-Gn:BSU32050" /db_xref="EnsemblGenomes-Tr:CAB15195" /db_xref="GOA:O32106" /db_xref="InterPro:IPR000819" /db_xref="InterPro:IPR008283" /db_xref="InterPro:IPR011356" /db_xref="InterPro:IPR023042" /db_xref="SubtiList:BG13970" /db_xref="UniProtKB/Swiss-Prot:O32106" /translation="MFYAVQQSEHTETLVVGLFQKSQLTGKALEIDEMLEGHLTQLLK EGDVSAKPNQVSKVFPPSSAGMKRIYFVGLGREANYSFEQAKERFAHVFQAIHKDRKQ ETAVLLDTFISEDVPPADAAHALAESCLLASYEVQDYKHKSNEPDKQIEAVYVVTDED TQEVQAGLRVGQAYGQGTNSARTLVNMPGNMLTATDLASYAEELAAKYDFECEILEKS EMEELGMGGILAVNQGSTEPPKMIVLKYQGKKEWEDVVGLVGKGITFDTGGYSIKTKS GIVGMKSDMGGAAAVLGAMETIGELRPEQNVLCVIPSTDNMISGGAMKPDDVIVSLSG KTIEILNTDAEGRLVLADGITYAKQHGASVLVDVATLTGGVVVALGTETTGAMTNDQS FYQQVADAAQECGEAIWQLPITEKDKKRVKSSQMADLSNSPGREGHAIMAGTFLGEFA ESTPWVHLDIAGTATANKATCFGPAGATGVMARTLATLAERFTLEEDKNE*" /label="pepA CDS" gene complement(2790855..2792357) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /label="pepA gene" downshifts complement(2790870) /Source="Nicolas_upshifts" /id="D1656" /incds=0 /nref=149 /ntot=220 /MaxReadThrough="4.44151" /MaxDrop="5.59726" /score="31.6277104" /energy="-16" /TU="NA" /idTUdmin="U2503" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 2791922..2791936 /Source="Nicolas_upshift_promotors" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2791938 /Source="Nicolas_upshifts" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2792358..2792432) /Source="Nicolas_S_feature" /locus_tag="new_3297920_3297994_c" /HighExp="M40t90, Lbtran, LBGtran, Lbstat, C90, M0t90, T1.0H, LoTm, M40t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1232" promotor_-35 2792380..2792387 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2792398..2792417 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2792400..2792514 /Source="Nicolas_S_feature" /locus_tag="new_3297962_3298076" /HighExp="Etha, Cold, Gly, Sw, LoTm, BC, B60, C90, dia5, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1233" upshifts 2792400 /Source="Nicolas_upshifts" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2792427..2792446) /Source="Nicolas_upshift_promotors" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2792437) /Source="Nicolas_upshifts" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="upshifts" CDS 2792515..2792991 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391086.1" /db_xref="EnsemblGenomes-Gn:BSU32060" /db_xref="EnsemblGenomes-Tr:CAB15196" /db_xref="GOA:O32107" /db_xref="InterPro:IPR003832" /db_xref="SubtiList:BG13969" /db_xref="UniProtKB/Swiss-Prot:O32107" /translation="MELLTNFPLLSSLAAIIFAQVIKVPIQFIVSRKLDWSLVTSTGG MPSSHSAAVTALSTGVALEHGLDSSLFAVSAIFAVITMFDATGVRRHAGEQATVINKL VIDFNRFVNEAKDFPKAAEKEKQKKLKELLGHQPIEVFFGGLTGILLTLVLAYFFM*" /label="yuiD CDS" gene 2792515..2792991 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /label="yuiD gene" downshifts 2792940 /Source="Nicolas_upshifts" /id="D1657" /incds=0 /nref=18 /ntot=174 /MaxReadThrough="3.22946" /MaxDrop="3.90704" /score="10.9647804" /energy="-11.6" /TU="U2502" /idTUdmin="U2502" /TUdmin="-208" /isTUend="FALSE" /label="downshifts" CDS complement(2793022..2793678) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /experiment="publication(s) with functional evidences, PMID:26163297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26163297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stationary phase survival protein" /protein_id="NP_391087.1" /db_xref="EnsemblGenomes-Gn:BSU32070" /db_xref="EnsemblGenomes-Tr:CAB15197" /db_xref="GOA:O32108" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR036908" /db_xref="PDB:4WJT" /db_xref="PDB:4WLI" /db_xref="PDB:4WLK" /db_xref="SubtiList:BG13968" /db_xref="UniProtKB/Swiss-Prot:O32108" /translation="MMLNMIRRLLMTCLFLLAFGTTFLSVSGIEAKDLSKWVQEHQEK HLKHAGLRLKALQQKQTQTTSAAEDKTKPLEEAFDWDEYPVQRVTATGYTAGAESTGK NPGDPLYGLTYSGVKVKRDLYSTVAADPSVFPIGTILFIPNYGLGVVADTGSAIKGNR LDLYFETVKDVYNEWGKKTLDVYVIKKGTGKITEDELEKLNETKSLQVFRNQYKTVKE *" /label="spsC CDS" gene complement(2793022..2793678) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /label="spsC gene" downshifts complement(2793050) /Source="Nicolas_upshifts" /id="D1658" /incds=0 /nref=178 /ntot=253 /MaxReadThrough="0.714039999999999" /MaxDrop="6.31907" /score="33.0538307" /energy="-12.6" /TU="NA" /idTUdmin="U2505" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2793326..2793335 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2793349..2793368 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2793366 /Source="Nicolas_upshifts" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="upshifts" S_feature 2793368..2793814 /Source="Nicolas_S_feature" /locus_tag="new_3298930_3299376" /HighExp="S6, S8, S7, BT, B36, G/S, S5, Pyr, Cold, B60" /AntisenseName="yuiC" /AntisenseCor="0.52395204592174105" /AntisenseRegPval="-19.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1234" upshifts complement(2793692) /Source="Nicolas_upshifts" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2793694..2793705) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2793720..2793726) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2793771 /Source="Nicolas_upshifts" /id="D1659" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="7.61734" /MaxDrop="4.9382" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin="-323" /isTUend="FALSE" /label="downshifts" CDS complement(2793782..2794102) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391088.1" /db_xref="EnsemblGenomes-Gn:BSU32080" /db_xref="EnsemblGenomes-Tr:CAB15198" /db_xref="GOA:O32109" /db_xref="InterPro:IPR025917" /db_xref="SubtiList:BG13967" /db_xref="UniProtKB/Swiss-Prot:O32109" /translation="MISLPVVIISIVLFFVLFFGIGFLLNMLLRMSWIMAVIYPIVCL FIISKEKLISYVQSPGESFASLFHRVLSLAAADVLILVSGLAGAIVSGIAINMLRKRG YQMF*" /label="yuiB CDS" gene complement(2793782..2794102) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /label="yuiB gene" downshifts complement(2793796) /Source="Nicolas_upshifts" /id="D1660" /incds=0 /nref=151 /ntot=218 /MaxReadThrough="4.24535" /MaxDrop="5.6597" /score="13.4559443" /energy="-7.6" /TU="U2507,U2508" /idTUdmin="U2510" /TUdmin=660 /isTUend="FALSE" /label="downshifts" S_feature 2793816..2794026 /Source="Nicolas_S_feature" /locus_tag="new_3299378_3299588" /HighExp="S8, S6, S7, BT, Cold, Gly, H2O2, G/S, C30, G180" /AntisenseName="yuiB" /AntisenseCor="-0.11290507783715401" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1235" promotor_no_box 2793968..2794068 /Source="Nicolas_upshift_promotors" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2794028..2794137 /Source="Nicolas_S_feature" /locus_tag="new_3299590_3299699" /HighExp="S8, S6, BT, S7, Sw, Gly, G180, BC, Diami, H2O2" /AntisenseName="yuiB" /AntisenseCor="-7.7565560595235006E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.03, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1236" upshifts 2794028 /Source="Nicolas_upshifts" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="upshifts" downshifts 2794094 /Source="Nicolas_upshifts" /id="D1661" /incds=0 /nref=10 /ntot=28 /MaxReadThrough="3.79664" /MaxDrop="6.06021" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2794121..2794140) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2794126) /Source="Nicolas_upshifts" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" S_feature 2794139..2794690 /Source="Nicolas_S_feature" /locus_tag="new_3299701_3300252" /HighExp="S6, S8, S7, Cold, H2O2, BC, Sw, Pyr, BT, C30" /AntisenseName="yuiA" /AntisenseCor="5.87811391089679E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1237" promotor_-35 complement(2794155..2794162) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2794156..2794299) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391089.1" /db_xref="EnsemblGenomes-Gn:BSU32090" /db_xref="EnsemblGenomes-Tr:CAB15199" /db_xref="InterPro:IPR035272" /db_xref="InterPro:IPR036410" /db_xref="SubtiList:BG12389" /db_xref="UniProtKB/Swiss-Prot:O32110" /translation="MKTATTTASHACPFCSGKGYFQLILGGSETCPSCQGTGKDSHSF SSR*" /label="yuiA CDS" gene complement(2794156..2794299) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /label="yuiA gene" promotor_-10 complement(2794323..2794342) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2794344) /Source="Nicolas_upshifts" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2794358..2794361) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2794472..2795692) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 17015645, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-disulfide oxidoreductase" /protein_id="NP_391090.1" /db_xref="EnsemblGenomes-Gn:BSU32100" /db_xref="EnsemblGenomes-Tr:CAB15200" /db_xref="GOA:O05267" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12390" /db_xref="UniProtKB/Swiss-Prot:O05267" /translation="MALNKPKIVILGAGYGGLMTVTRLTKYVGPNDADITLVNKHNYH YETTWMHEASAGTLHHDRCRYQIKDVINQSRVNFVQDTVKAIKIDEKKVVLANGELQY DYLVIGLGAVPETFGIKGLKEYAFPIANINTSRLLREHIELQFATYNTEAEKRPDRLT IVVGGAGFTGIEFLGELAARVPELCKEYDVDRSLVRIICVEAAPTVLPGFDPELVDYA VHYLEENGVEFKIGTAVQECTPEGVRVGKKDEEPEQIKSQTVVWAAGVRGHPIVEEAG FENMRGRVKVNPDLRAPGHDNVFILGDSSLFMNEDTERPYPPTAQIAMQQGITVAKNL GRLIKGGELEEFKPDIKGTVASLGEHNAVGVVYGRKLKGTPASFMKKVIDNRSLFMIG GLGLTLKKGKFKFF*" /label="yumB CDS" gene complement(2794472..2795692) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /label="yumB gene" downshifts complement(2794500) /Source="Nicolas_upshifts" /id="D1662" /incds=0 /nref=15 /ntot=123 /MaxReadThrough="3.19525" /MaxDrop="3.6794" /score="23.523765" /energy="-8.9" /TU="U2510" /idTUdmin="U2509" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2795693..2795820) /Source="Nicolas_S_feature" /locus_tag="new_3301255_3301382_c" /HighExp="Salt, S4, Etha, S5, S3, S7, S6, LoTm, B36, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.752, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1238" upshifts complement(2795820) /Source="Nicolas_upshifts" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2795822..2795886) /Source="Nicolas_S_feature" /locus_tag="new_3301384_3301448_c" /HighExp="Salt, Etha, Heat, BMM, BC, H2O2, Paraq, C30, Sw, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1239" promotor_-10 complement(2795822..2795840) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2795856..2795861) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2795877..2795896) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2795885) /Source="Nicolas_upshifts" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2795911..2795918) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2795960..2795967 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2795979..2795998 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2795979 /Source="Nicolas_upshifts" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="upshifts" CDS 2796024..2797022 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /EC_number="1.18.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15252706, 22938038, 26507228, 26965753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 22938038, 26507228, 26965753; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferredoxin-NADP+ reductase (flavodoxin)" /protein_id="NP_391091.2" /db_xref="EnsemblGenomes-Gn:BSU32110" /db_xref="EnsemblGenomes-Tr:CAB15201" /db_xref="GOA:O05268" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="PDB:3LZW" /db_xref="PDB:3LZX" /db_xref="SubtiList:BG12391" /db_xref="UniProtKB/Swiss-Prot:O05268" /translation="MREDTKVYDITIIGGGPVGLFTAFYGGMRQASVKIIESLPQLGG QLSALYPEKYIYDVAGFPKIRAQELINNLKEQMAKFDQTICLEQAVESVEKQADGVFK LVTNEETHYSKTVIITAGNGAFKPRKLELENAEQYEGKNLHYFVDDLQKFAGRRVAIL GGGDSAVDWALMLEPIAKEVSIIHRRDKFRAHEHSVENLHASKVNVLTPFVPAELIGE DKIEQLVLEEVKGDRKEILEIDDLIVNYGFVSSLGPIKNWGLDIEKNSIVVKSTMETN IEGFFAAGDICTYEGKVNLIASGFGEAPTAVNNAKAYMDPKARVQPLHSTSLFENK*" /label="trxBB CDS" gene 2796024..2797022 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /label="trxBB gene" promotor_-10 complement(2796047..2796065) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2796062) /Source="Nicolas_upshifts" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2796082..2796087) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2796998 /Source="Nicolas_upshifts" /id="D1663" /incds=0 /nref=162 /ntot=262 /MaxReadThrough="0.70088" /MaxDrop="7.47867" /score="21.6819221" /energy="-12.8" /TU="U2511" /idTUdmin="U2511" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2797061..2797201) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein or unknown function" /protein_id="NP_391092.1" /db_xref="EnsemblGenomes-Gn:BSU32120" /db_xref="EnsemblGenomes-Tr:CAB15202" /db_xref="GOA:O32111" /db_xref="SubtiList:BG14056" /db_xref="UniProtKB/Swiss-Prot:O32111" /translation="MAQNEEKTPKSQKIQDRIIMAMIWVVAALVIALVVGTALNYINI FK*" /label="yuzG CDS" gene complement(2797061..2797201) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /label="yuzG gene" downshifts complement(2797073) /Source="Nicolas_upshifts" /id="D1664" /incds=0 /nref=61 /ntot=234 /MaxReadThrough="1.27572" /MaxDrop="5.65243" /score="32.0354025" /energy="-12.8" /TU="NA" /idTUdmin="U2515" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(2797202..2797331) /Source="Nicolas_S_feature" /locus_tag="new_3302764_3302893_c" /HighExp="dia15, Salt, Cold, Diami, H2O2, Etha, GM 15, dia5, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.36371900000000001" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1240" promotor_-10 complement(2797312..2797331) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2797331) /Source="Nicolas_upshifts" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2797333..2797580) /Source="Nicolas_S_feature" /locus_tag="new_3302895_3303142_c" /HighExp="S8, S5, S6, S7, S4, ferm, nit, C30, Pyr, T5.0H" /AntisenseName="guaC" /AntisenseCor="-0.291283195124732" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1241" promotor_-35 complement(2797345..2797351) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2797388..2797395 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2797409..2797428 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2797417 /Source="Nicolas_upshifts" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2797480..2798460 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /EC_number="1.7.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 11591660, 6408059" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 11591660, 6408059; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP reductase (NADP-dependent)" /protein_id="NP_391093.2" /db_xref="EnsemblGenomes-Gn:BSU32130" /db_xref="EnsemblGenomes-Tr:CAB15203" /db_xref="GOA:O05269" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005994" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG12392" /db_xref="UniProtKB/Swiss-Prot:O05269" /translation="MENVFDYEDIQLIPAKCIVNSRSECDTSVRLGGHTFKLPVVPAN MQTIIDEKLAISLAENGYFYVMHRFEPETRIDFIKDMNARGLFSSISVGVKDEEYEFV RQLAEENLTPEYVTIDIAHGHSNAVIEMIQHLKKHLPDSFVIAGNVGTPEAVRELENA GADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAK SIRFGATMVMIGSLFAGHEESPGQTIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMHV AHKGSIKDTLIEMEQDLQSSISYAGGTKLNAIRNVDYVIVKNSIFNGDKY*" /label="guaC CDS" gene 2797480..2798460 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /label="guaC gene" upshifts complement(2797581) /Source="Nicolas_upshifts" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2797585..2797596) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2797610..2797616) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2798428 /Source="Nicolas_upshifts" /id="D1665" /incds=0 /nref=91 /ntot=186 /MaxReadThrough="1.24882" /MaxDrop="7.43286" /score="-2.82053244" /energy="-16.2" /TU="NA" /idTUdmin="U2514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2798533) /Source="Nicolas_upshifts" /id="D1666" /incds=0 /nref=24 /ntot=212 /MaxReadThrough="1.15696" /MaxDrop="6.12198" /score="23.834956" /energy="-16.2" /TU="NA" /idTUdmin="U2517" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2798534..2799157) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16210326, 21633969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates paiA expression)" /protein_id="NP_391094.2" /db_xref="EnsemblGenomes-Gn:BSU32140" /db_xref="EnsemblGenomes-Tr:CAB15204" /db_xref="GOA:P21341" /db_xref="InterPro:IPR007396" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG10696" /db_xref="UniProtKB/Swiss-Prot:P21341" /translation="MYIPKYFKVTNAEEIWNFVQENSFGTVVTTEQGKPIATHLPLGF NKKDDHYYITGHFAYGNPQWRTFEACEDVLVMFQGPHAYISSSWYSRENVPTWNYQAV HMYGKASMLEKDELAEELTIMLEKYEKHRDNPVLWDKLSPKLLESELKGIVGFKIKVE DIQAAYKLSQNRNETDYMNVIEQLQNEENPNAKQMAELMEDKLKKQI*" /label="paiB CDS" gene complement(2798534..2799157) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /label="paiB gene" CDS complement(2799181..2799699) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /EC_number="2.3.1.57" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16210326, 17588214, 21633970, 26818562, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16210326, 17588214, 21633970, 26818562, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyamine N-acetyltransferase" /protein_id="NP_391095.1" /db_xref="EnsemblGenomes-Gn:BSU32150" /db_xref="EnsemblGenomes-Tr:CAB15205" /db_xref="GOA:P21340" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1TIQ" /db_xref="SubtiList:BG10695" /db_xref="UniProtKB/Swiss-Prot:P21340" /translation="MSVKMKKCSREDLQTLQQLSIETFNDTFKEQNSPENMKAYLESA FNTEQLEKELSNMSSQFFFIYFDHEIAGYVKVNIDDAQSEEMGAESLEIERIYIKNSF QKHGLGKHLLNKAIEIALERNKKNIWLGVWEKNENAIAFYKKMGFVQTGAHSFYMGDE EQTDLIMAKTLI*" /label="paiA CDS" gene complement(2799181..2799699) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /label="paiA gene" misc_feature complement(2799746..2799765) /Source="Nicolas_upshift_promotors" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2799758) /Source="Nicolas_upshifts" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2799760..2799868) /Source="Nicolas_S_feature" /locus_tag="new_3305322_3305430_c" /HighExp="LoTm, HiTm, G135, Salt, G180, Cold, LBGstat, T0.0H, B36, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1242" promotor_-10 complement(2799855..2799872) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2799866) /Source="Nicolas_upshifts" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2799887..2799894) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2800022) /Source="Nicolas_upshifts" /id="D1667" /incds=0 /nref=267 /ntot=269 /MaxReadThrough="1.56881" /MaxDrop="8.24828" /score="12.6937405" /energy="-18.7" /TU="NA" /idTUdmin="U2518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2800037..2800399) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17698959, 19478995, 20097860, 25447545; Product type c: carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier chaperone involved in Fe-S cluster assembly" /protein_id="NP_391096.1" /db_xref="EnsemblGenomes-Gn:BSU32160" /db_xref="EnsemblGenomes-Tr:CAB15206" /db_xref="GOA:O32113" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR016092" /db_xref="InterPro:IPR017870" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG14049" /db_xref="UniProtKB/Swiss-Prot:O32113" /translation="MSNPVTITEAAALHIKDMMKEHEEENAFLRVGVKGGGCSGLSYG MGFEHEKSESDSVFDQHGITVLVDKESLDIMNGTVIDYKQSMLGGGFTIDNPNAIASC GCGSSFRTATNAGKPEEC*" /label="sufA CDS" gene complement(2800037..2800399) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /label="sufA gene" promotor_-10 complement(2800430..2800449) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2800440) /Source="Nicolas_upshifts" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2800463..2800470) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2800478..2801332) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /EC_number="5.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 14627808, 16723397, 19307721, 28873470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diaminopimelate epimerase" /protein_id="NP_391097.1" /db_xref="EnsemblGenomes-Gn:BSU32170" /db_xref="EnsemblGenomes-Tr:CAB15207" /db_xref="GOA:O32114" /db_xref="InterPro:IPR001653" /db_xref="InterPro:IPR018510" /db_xref="SubtiList:BG14048" /db_xref="UniProtKB/Swiss-Prot:O32114" /translation="MNSFRFTKMHGLGNSYIYVNQFEEQLPEEKLSEIAIQVSSVYTG IGSDGMILICPSDQAPVKMRIFNNDGSEGKNCGNGLRCVAKYAYEHKLVEETSFLIET LSGLVKAEVQVENGKVNVVTVDMGEPRLTKSELPMLDGGEEHTINETMAFGEVELTGT AVSMGNPHIVFPIADIEQAPLTTLGPVIEKDPRFPEGINVEFVETVNEQELHFRVWER GSGITQACGTGACAAAVASVLNGVSKRNQDITVHLAGGDLVINWKDNGHVMMTGPAET VCEGVYFL*" /label="dapF CDS" gene complement(2800478..2801332) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /label="dapF gene" promotor_-10 complement(2801048..2801067) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2801056) /Source="Nicolas_upshifts" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2801080..2801089) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2801354..2801373) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2801368) /Source="Nicolas_upshifts" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2801388..2801391) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2801455..2802669) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+(H+)/nucleoside cotransporter" /protein_id="NP_391098.1" /db_xref="EnsemblGenomes-Gn:BSU32180" /db_xref="EnsemblGenomes-Tr:CAB15208" /db_xref="GOA:O32115" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG14047" /db_xref="UniProtKB/Swiss-Prot:O32115" /translation="MNVLWGLLGAVAIIAIAFLFSEKKSNIKIRTVIVGLCTQVAFGY IVLKWEAGRAVFLWFSSRVQLLIDYANEGISFIFGPLLKVGDSPAFALSVLPVIIFFS ALIAVLYHLKIMQLVFRVIGGGLSKLLGTSKTESLAAAANIFVGQSESPLVIKPLIAG LTRSELFTIMTSGLSAVAGSTLFGYALLGIPIEYLLAASFMAAPAGLVFGKLIIPETE KTQTVKSDFKMDEGEGAANVIDAAAKGASTGLQIALNVGAMLLAFVALIAVVNGILGG AFGLFGLKGVTLESILGYVFSPIAFLIGVPWHEALQAGSYIGQKLVLNEFVAYSNFGS HIGEFSKKTATIISFALCGFANFSSIAIMLGTLGGLAPSRRSDIARLGLKAVLAGTLA NLLSAAIAGMFI*" /label="yutK CDS" gene complement(2801455..2802669) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /label="yutK gene" promotor_-35 2802004..2802010 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2802025..2802043 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2802032 /Source="Nicolas_upshifts" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="upshifts" S_feature 2802036..2802805 /Source="Nicolas_S_feature" /locus_tag="new_3307598_3308367" /HighExp="Etha, Salt, Gly, M9-stat, Sw, LoTm, B60, BC, Heat, S0" /AntisenseName="yutK" /AntisenseCor="-0.36240965013078302" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1243" promotor_-10 complement(2802706..2802725) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-10" upshifts complement(2802711) /Source="Nicolas_upshifts" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="upshifts" promotor_-35 complement(2802740..2802747) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-35" downshifts 2802762 /Source="Nicolas_upshifts" /id="D1668" /incds=0 /nref=3 /ntot=58 /MaxReadThrough="4.13852" /MaxDrop="3.94079" /score="20.5760616" /energy="-10.5" /TU="U2521" /idTUdmin="U2521" /TUdmin="-1913" /isTUend="FALSE" /label="downshifts" CDS complement(2802806..2803042) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391099.1" /db_xref="EnsemblGenomes-Gn:BSU32190" /db_xref="EnsemblGenomes-Tr:CAB15209" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR022916" /db_xref="SubtiList:BG14051" /db_xref="UniProtKB/Swiss-Prot:O32116" /translation="MNPMIEFCVSNLAHGSQEARAILEKDPNLDVLEYGCLSYCGTCM ESLFALVNGEVVMGETPAELVENIYTFIEENPMF*" /label="yuzB CDS" gene complement(2802806..2803042) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /label="yuzB gene" S_feature 2802807..2803223 /Source="Nicolas_S_feature" /locus_tag="new_3308369_3308785" /HighExp="Salt, LoTm, Gly, Etha, Sw, Heat, S0, C30, M9-stat, Mal" /AntisenseName="yuzB" /AntisenseCor="-5.6824456709843603E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1244" downshifts complement(2802824) /Source="Nicolas_upshifts" /id="D1669" /incds=0 /nref=175 /ntot=239 /MaxReadThrough="1.28789" /MaxDrop="7.32368" /score="41.4640292" /energy="-10.5" /TU="NA" /idTUdmin="U2523" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2803007..2803008) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2803012..2803016) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2803014) /Source="Nicolas_upshifts" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2803057..2803076) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2803058) /Source="Nicolas_upshifts" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2803090..2803097) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2803200..2803205 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2803219..2803238 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2803225 /Source="Nicolas_upshifts" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="upshifts" CDS 2803305..2804372 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /EC_number="1.6.-.-" /function="16.10: Respire" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17015645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH dehydrogenase" /protein_id="NP_391100.2" /db_xref="EnsemblGenomes-Gn:BSU32200" /db_xref="EnsemblGenomes-Tr:CAB15210" /db_xref="GOA:O32117" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14046" /db_xref="UniProtKB/Swiss-Prot:O32117" /translation="MKKLVLIGGGYGNMRVLHRLLPNQLPDDVSITLIDRNPYHCLKT EYYALAAGTISDHHIRVSFPEHPRLDVQYGDITSIDIVQKQVLFQDREPISYDDAIIG LGCEDKYHNVPGAPEFTYSIQTIDQSRETYQKLNNLSANATVAIVGAGLSGVELASEL RESRDDLNIILFDRGNLILSSFPERLSKYVQKWFEEHGVRIINRANITKVEEGVVYNH DDPISADAIVWTAGIQPNKVVRDLDVEKDAQGRIVLTPHHNLPGDEHLYVVGDCASLP HAPSAQLAEAQAEQIVQILQKRWNGEALPESMPQFKLKGVLGSLGKKAGFGLVADRPL IGRVPRMLKSGLLWMYKHHNG*" /label="yutJ CDS" gene 2803305..2804372 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /label="yutJ gene" downshifts 2804356 /Source="Nicolas_upshifts" /id="D1670" /incds=0 /nref=4 /ntot=110 /MaxReadThrough="3.51945" /MaxDrop="3.02708" /score="6.15657679" /energy="-10.8" /TU="U2521,U2525" /idTUdmin="U2521" /TUdmin="-319" /isTUend="FALSE" /label="downshifts" CDS complement(2804398..2804724) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11551182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reduction management enzyme" /protein_id="NP_391101.1" /db_xref="EnsemblGenomes-Gn:BSU32210" /db_xref="EnsemblGenomes-Tr:CAB15211" /db_xref="InterPro:IPR009190" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14053" /db_xref="UniProtKB/Swiss-Prot:O32118" /translation="MMKPVMLSVYGAENVCASCVNMPTAKDTYEWLEAALKRKYPNQP FEMQYIDIHEPPDNEHAKELAEKIRNDEYFYPLVLVEDKIVGEGNPKLKDVYEEMEKH GYTENR*" /label="yuzD CDS" gene complement(2804398..2804724) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /label="yuzD gene" downshifts complement(2804421) /Source="Nicolas_upshifts" /id="D1671" /incds=0 /nref=4 /ntot=180 /MaxReadThrough="1.63835" /MaxDrop="3.17377" /score="-8.05690984" /energy="-10.8" /TU="NA" /idTUdmin="U2526" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2804756..2804775) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2804773) /Source="Nicolas_upshifts" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2804788..2804795) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2804808..2804812 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2804824..2805159 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17237162, 21749987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative iron-sulfur scaffold protein" /protein_id="NP_391102.1" /db_xref="EnsemblGenomes-Gn:BSU32220" /db_xref="EnsemblGenomes-Tr:CAB15212" /db_xref="GOA:O32119" /db_xref="InterPro:IPR001075" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG14045" /db_xref="UniProtKB/Swiss-Prot:O32119" /translation="MCYNRESNFANQTIDFYCYTEYNGFMTTKGANVMTEVEMKEQVQ EVLDKLRPFLLRDGGDCELVDVDEGIVKLRLLGACGSCPSSTITLKAGIERALLEEVP GVVEVEQVF*" /label="yutI CDS" gene 2804824..2805159 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /label="yutI gene" promotor_-10 2804825..2804844 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2804830 /Source="Nicolas_upshifts" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2804949) /Source="Nicolas_upshifts" /id="D1672" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="1.28655" /MaxDrop="3.45909" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2805137 /Source="Nicolas_upshifts" /id="D1673" /incds=0 /nref=258 /ntot=281 /MaxReadThrough="3.6035" /MaxDrop="7.98922" /score="39.7008566" /energy="-19.5" /TU="U2527" /idTUdmin="U2527" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(2805201..2807174) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8576092, 11406580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acylaminoacyl-peptidase" /protein_id="NP_391103.2" /db_xref="EnsemblGenomes-Gn:BSU32230" /db_xref="EnsemblGenomes-Tr:CAB15213" /db_xref="GOA:P39839" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10463" /db_xref="UniProtKB/Swiss-Prot:P39839" /translation="MKKLITADDITAIVSVTDPQYAPDGTRAAYVKSQVNQEKDSYTS NIWIYETKTGGSVPWTHGEKRSTDPRWSPDGRTLAFISDREGDAAQLYIMSTEGGEAR KLTDIPYGVSKPLWSPDGESILVTVSLGEGESIDDREKTEQDSYEPVEVQGLSYKRDG KGLTRGAYAQLVLVSVKSGEMKELTSHKADHGDPAFSPDGKWLVFSANLTETDDASKP HDVYIMSLESGDLKQVTPHRGSFGSSSFSPDGRYLALLGNEKEYKNATLSKAWLYDIE QGRLTCLTEMLDVHLADALIGDSLIGGAEQRPIWTKDSQGFYVIGTDQGSTGIYYISI EGLVYPIRLEKEYINSFSLSPDEQHFIASVTKPDRPSELYSIPLGQEEKQLTGANDKF VREHTISIPEEIQYATEDGVMVNGWLMRPAQMEGETTYPLILNIHGGPHMMYGHTYFH EFQVLAAKGYAVVYINPRGSHGYGQEFVNAVRGDYGGKDYDDVMQAVDEAIKRDPHID PKRLGVTGGSYGGFMTNWIVGQTNRFKAAVTQRSISNWISFHGVSDIGYFFTDWQLEH DMFEDTEKLWDRSPLKYAANVETPLLILHGERDDRCPIEQAEQLFIALKKMGKETKLV RFPNASHNLSRTGHPRQRIKRLNYISSWFDQHL*" /label="yuxL CDS" gene complement(2805201..2807174) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /label="yuxL gene" downshifts complement(2805213) /Source="Nicolas_upshifts" /id="D1674" /incds=0 /nref=19 /ntot=114 /MaxReadThrough="1.79797" /MaxDrop="3.85507" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2807189..2807207) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2807212) /Source="Nicolas_upshifts" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2807219..2807227) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2807282..2808211) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /EC_number="2.7.1.39" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine kinase" /protein_id="NP_391104.1" /db_xref="EnsemblGenomes-Gn:BSU32240" /db_xref="EnsemblGenomes-Tr:CAB15214" /db_xref="GOA:P04948" /db_xref="InterPro:IPR000870" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10462" /db_xref="UniProtKB/Swiss-Prot:P04948" /translation="MNEADMLFSVTVPGSTANLGPGFDSVGMALSRYLKLTVFESDKW SFEAETETVAGIPAGTDNLIYQVAKRTADLYGKEMPPVHVKVWSDIPLARGLGSSAAA IVAAIELADELCGLKLSEADKLHLASLEEGHPDNAGASLVGGLVIGLHEDDETQMIRV PNADIDVVVVIPFYEVLTRDARDVLPKEFPYADAVKASAVSNILIAAIMSKDWPLVGK IMKKDMFHQPYRAMLVPELSKVEHVAEMKGAYGTALSGAGPTILVMTEKGKGEELKEQ LALHFPHCEVDALTVPKEGSIIERNPLYQVKSV*" /label="thrB CDS" gene complement(2807282..2808211) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /label="thrB gene" downshifts complement(2807295) /Source="Nicolas_upshifts" /id="D1675" /incds=0 /nref=222 /ntot=261 /MaxReadThrough="2.39521" /MaxDrop="7.03759" /score="15.5945196" /energy="-10.3" /TU="NA" /idTUdmin="U2530" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2808208..2809266) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /EC_number="4.2.3.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 3139660, 8768250" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 3139660, 8768250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine synthase" /protein_id="NP_391105.1" /db_xref="EnsemblGenomes-Gn:BSU32250" /db_xref="EnsemblGenomes-Tr:CAB15215" /db_xref="GOA:P04990" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR004450" /db_xref="InterPro:IPR026260" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10461" /db_xref="UniProtKB/Swiss-Prot:P04990" /translation="MWKGLIHQYKEFLPVTDQTPALTLHEGNTPLIHLPKLSEQLGIE LHVKTEGVNPTGSFKDRGMVMAVAKAKEEGNDTIMCASTGNTSAAAAAYAARANMKCI VIIPNGKIAFGKLAQAVMYGAEIIAIDGNFDDALKIVRSICEKSPIALVNSVNPYRIE GQKTAAFEVCEQLGEAPDVLAIPVGNAGNITAYWKGFKEYHEKNGTGLPKMRGFEAEG AAAIVRNEVIENPETIATAIRIGNPASWDKAVKAAEESNGKIDEVTDDEILHAYQLIA RVEGVFAEPGSCASIAGVLKQVKSGEIPKGSKVVAVLTGNGLKDPNTAVDISEIKPVT LPTDEDSILEYVKGAARV*" /label="thrC CDS" gene complement(2808208..2809266) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /label="thrC gene" CDS complement(2809266..2810567) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /EC_number="1.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3139660, 27299409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3139660, 27299409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine dehydrogenase" /protein_id="NP_391106.1" /db_xref="EnsemblGenomes-Gn:BSU32260" /db_xref="EnsemblGenomes-Tr:CAB15216" /db_xref="GOA:P19582" /db_xref="InterPro:IPR001342" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005106" /db_xref="InterPro:IPR016204" /db_xref="InterPro:IPR019811" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10460" /db_xref="UniProtKB/Swiss-Prot:P19582" /translation="MKAIRVGLLGLGTVGSGVVKIIQDHQDKLMHQVGCPVTIKKVLV KDLEKKREVDLPKEVLTTEVYDVIDDPDVDVVIEVIGGVEQTKQYLVDALRSKKHVVT ANKDLMAVYGSELLAEAKENGCDIYFEASVAGGIPILRTLEEGLSSDRITKMMGIVNG TTNFILTKMIKEKSPYEEVLKEAQDLGFAEADPTSDVEGLDAARKMAILARLGFSMNV DLEDVKVKGISQITDEDISFSKRLGYTMKLIGIAQRDGSKIEVSVQPTLLPDHHPLSA VHNEFNAVYVYGEAVGETMFYGPGAGSMPTATSVVSDLVAVMKNMRLGVTGNSFVGPQ YEKNMKSPSDIYAQQFLRIHVKDEVGSFSKITSVFSERGVSFEKILQLPIKGHDELAE IVIVTHHTSEADFSDILQNLNDLEVVQEVKSTYRVEGNGWS*" /label="hom CDS" gene complement(2809266..2810567) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /label="hom gene" promotor_-35 2810452..2810461 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2810476..2810495 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2810483 /Source="Nicolas_upshifts" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2810568..2810649) /Source="Nicolas_S_feature" /locus_tag="new_3316130_3316211_c" /HighExp="T3.0H, T2.30H, T3.30H, S2, C90, T4.0H, BMM, SMM, MG 120, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1245" promotor_-10 complement(2810634..2810653) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2810649) /Source="Nicolas_upshifts" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2810651..2810767) /Source="Nicolas_S_feature" /locus_tag="new_3316213_3316329_c" /HighExp="S5, S3, S4, S7, S6, S8, BT, B36, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1246" promotor_-35 complement(2810668..2810675) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2810768..2811787) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /function="16.3: Control" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15231775, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat-associated protein" /protein_id="NP_391107.1" /db_xref="EnsemblGenomes-Gn:BSU32270" /db_xref="EnsemblGenomes-Tr:CAB15217" /db_xref="GOA:O32123" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014254" /db_xref="SubtiList:BG14044" /db_xref="UniProtKB/Swiss-Prot:O32123" /translation="MVKGTIKEKYGIHIRQLSMYQHTYQCFQTPNSYFLIVPVSQFSE TELAELYYMSQYLQEQSDPYVSVFIFTKEGELTFEHEGKTYALLKAAPPYSNRAFSIG AELAEFHRKGRGYPYEVKAAGRIGQWKDLWGKRIDQLEAFWQRKVQTPPHEPFDKKMI ESFPYYLGLSENAIQYLVDTELDDKPQAADSGTICHQRMERHTWSPESLIRIPADWVF DHASRDLAEYMRHTFLHHRQDFNQQGFLFLQEYEQVTPLSSFSKRLLYSRLLFPLHYF EIVESYYMSSESEKHYFEEQLDFILNDCGRYEQFLNTAQEFMNMRAQKLFVPRVSWLG KGSSR*" /label="cotNH CDS" gene complement(2810768..2811787) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /label="cotNH gene" promotor_-35 2811595..2811600 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2811616..2811634 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2811620 /Source="Nicolas_upshifts" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2811810..2811828) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2811817) /Source="Nicolas_upshifts" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2811826..2811831 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2811844..2811849) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2811847..2811911 /Source="Nicolas_S_feature" /locus_tag="new_3317409_3317473" /HighExp="S4, S5, S3, S6, S7, B36, S8, LoTm, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1247" promotor_-10 2811847..2811865 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2811847 /Source="Nicolas_upshifts" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2811884..2811893 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2811906..2811925 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2811913 /Source="Nicolas_upshifts" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="upshifts" CDS 2811940..2812440 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_391108.1" /db_xref="EnsemblGenomes-Gn:BSU32280" /db_xref="EnsemblGenomes-Tr:CAB15218" /db_xref="GOA:O32124" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="SubtiList:BG14043" /db_xref="UniProtKB/Swiss-Prot:O32124" /translation="MSENEQFSQMEAKARARMKERGVEVSDIAELVFFLQKKYHPDLT IDECTLNVNRVLAKREVQNAILTGIELDVLAEQKKLSEPLQTMLEIDESLYGVDEVLA FSIVNIYGSIGFTNYGYIDKEKPGILKRLNDKSTGECHTFLDDIVGAISAAASSRLAH RARHTE*" /label="yutG CDS" gene 2811940..2812440 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /label="yutG gene" CDS complement(2812467..2813237) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /EC_number="3.1.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15664928, 16766528, 27907199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15664928, 16766528, 27907199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5' nucleotidase, promiscuous" /protein_id="NP_391109.1" /db_xref="EnsemblGenomes-Gn:BSU32290" /db_xref="EnsemblGenomes-Tr:CAB15219" /db_xref="GOA:O32125" /db_xref="InterPro:IPR006354" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3PDW" /db_xref="SubtiList:BG14042" /db_xref="UniProtKB/Swiss-Prot:O32125" /translation="MKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTN NSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIE ENGLTFGGENADFVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPG NGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINA GMDTLLVHTGVTKREHMTDDMEKPTHAIDSLTEWIPYI*" /label="nucF CDS" gene complement(2812467..2813237) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /label="nucF gene" downshifts complement(2812495) /Source="Nicolas_upshifts" /id="D1676" /incds=0 /nref=137 /ntot=243 /MaxReadThrough="2.15034" /MaxDrop="4.82801" /score="8.09889752" /energy="-15.6" /TU="NA" /idTUdmin="U2535" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2813266..2813700) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391110.1" /db_xref="EnsemblGenomes-Gn:BSU32300" /db_xref="EnsemblGenomes-Tr:CAB15220" /db_xref="InterPro:IPR008201" /db_xref="PDB:1YLM" /db_xref="SubtiList:BG14041" /db_xref="UniProtKB/Swiss-Prot:O32126" /translation="MYFVDRSKIEKTLGFFEHQLALFDSQTDWQSEIGELALQRIGHL LIECILDTGNDMIDGFIMRDPGSYDDIMDILVDEKVVTEKEGDELKKLIAYRKTLVQQ YLLADSGELYRLIKAHQTALQDFPKRIRSYLETELGPVSAFK*" /label="yutE CDS" gene complement(2813266..2813700) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /label="yutE gene" CDS complement(2813724..2813999) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12770717, 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391111.2" /db_xref="EnsemblGenomes-Gn:BSU32310" /db_xref="EnsemblGenomes-Tr:CAB15221" /db_xref="InterPro:IPR009370" /db_xref="PDB:2KL5" /db_xref="SubtiList:BG14040" /db_xref="UniProtKB/Swiss-Prot:O32127" /translation="MILIQNAEFELVHNFKDGFNEEAFKARYSDILNKYDYIVGDWGY GQLRLKGFFDDQNQKATFETKISTLDEYIYEYCNFGCAYFVLKRIRK*" /label="yutD CDS" gene complement(2813724..2813999) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /label="yutD gene" promotor_-10 complement(2814019..2814038) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2814044) /Source="Nicolas_upshifts" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2814046..2814738) /Source="Nicolas_S_feature" /locus_tag="new_3319608_3320300_c" /HighExp="G135, G150, G180, H2O2, LBGtran, LBGexp, Paraq, dia15, C90, HiOs" /AntisenseName="yutC" /AntisenseCor="-0.57886192731570996" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1248" promotor_-35 complement(2814052..2814059) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2814062..2814068 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2814083..2814094 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2814091 /Source="Nicolas_upshifts" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="upshifts" CDS 2814114..2814746 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative sporulation-related lipoprotein" /protein_id="NP_391112.1" /db_xref="EnsemblGenomes-Gn:BSU32320" /db_xref="EnsemblGenomes-Tr:CAB15222" /db_xref="GOA:O32128" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG14039" /db_xref="UniProtKB/Swiss-Prot:O32128" /translation="MKRTAVSLCLLTGLLSGCGGAGLDNAQNVRNQTQNQTKPIHVSD RNEAFNRHNENEQFGYVRYQKEQFDGEQQKTPVMNREETAHMISSLTVQLPHIQDAAT LVTDREALVVYKTDSKNRELTADQVKKTAASVIPRYYHVYISDNPNHMQSVENYSNLG SGSRDIREIMSGTIQEMKTSPQGSPVSENENANGETRQDMKIDRNDKNAR*" /label="yutC CDS" gene 2814114..2814746 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /label="yutC gene" downshifts 2814707 /Source="Nicolas_upshifts" /id="D1677" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="1.84979" /MaxDrop="3.55825" /score="-2.38634221" /energy="-9.6" /TU="NA" /idTUdmin="U2536" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2814762..2815658) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /EC_number="2.8.1.8" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15362861, 16835858, 19028902, 19820084, 25341020; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoyl synthase (lipoic acid synthetase)" /protein_id="NP_391113.2" /db_xref="EnsemblGenomes-Gn:BSU32330" /db_xref="EnsemblGenomes-Tr:CAB15223" /db_xref="GOA:O32129" /db_xref="InterPro:IPR003698" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031691" /db_xref="SubtiList:BG14038" /db_xref="UniProtKB/Swiss-Prot:O32129" /translation="MAKKDEHLRKPEWLKIKLNTNENYTGLKKLMRENNLHTVCEEAK CPNIHECWAVRRTATFMILGSVCTRACRFCAVKTGLPTELDLQEPERVADSVALMNLK HAVITAVARDDQKDGGAGIFAETVRAIRRKSPFTTIEVLPSDMGGNYDNLKTLMDTRP DILNHNIETVRRLTPRVRARATYDRSLEFLRRAKEMQPDIPTKSSIMIGLGETKEEII EVMDDLLANNVDIMAIGQYLQPTKKHLKVQKYYHPDEFAELKEIAMQKGFSHCEAGPL VRSSYHADEQVNEASKKRQAQA*" /label="lipA CDS" gene complement(2814762..2815658) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /label="lipA gene" downshifts complement(2814783) /Source="Nicolas_upshifts" /id="D1678" /incds=0 /nref=186 /ntot=261 /MaxReadThrough="3.83236" /MaxDrop="5.33309" /score="14.803008" /energy="-9.6" /TU="U2537" /idTUdmin="U2537" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(2815659..2815793) /Source="Nicolas_S_feature" /locus_tag="new_3321221_3321355_c" /HighExp="HiOs, LBGtran, dia15, dia5, C90, Diami, dia0, LBGexp, Heat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1249" promotor_-10 complement(2815780..2815799) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-10" upshifts complement(2815793) /Source="Nicolas_upshifts" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="upshifts" promotor_-35 complement(2815815..2815819) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-35" promotor_-35 2815833..2815839 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2815853..2815864 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2815865 /Source="Nicolas_upshifts" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="upshifts" CDS 2815893..2816873 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /EC_number="3.4.-.-" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12813075; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific L-Ala-D-Glu endopeptidase" /protein_id="NP_391114.2" /db_xref="EnsemblGenomes-Gn:BSU32340" /db_xref="EnsemblGenomes-Tr:CAB15224" /db_xref="GOA:O32130" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG13975" /db_xref="UniProtKB/Swiss-Prot:O32130" /translation="MKVLLSALLLLLFAFEPSASGKKLSDPVLSKRMELYHKIEAVTQ IPWYALAAVDQYEENVRSNRKDLPEKAGIISIYIPDDIWSGPENPNPKDDAPLSIKVF DGIGMDGDGDGKAEVSNDEDILYTFSQYLLSYGTDEDNIRIGLWNYYRRDQTVGIISE FMKLFKAYGHIDLGEHAFPLPIRTDYSYRSTWGDARGFGGRRIHEGTDIFAHYGLPVK STCYGVVEMKGWNRFGGWRIGIRDINNTYHYFAHLNGFAKGIKTGQIVEPGQVIGSVG SSGYGPPGTAGKFPPHLHYGMYKDNGRTEWSFDPYPHLRAWERYEYQKKK*" /label="lytH CDS" gene 2815893..2816873 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /label="lytH gene" upshifts complement(2815971) /Source="Nicolas_upshifts" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2815985..2816004) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2816021..2816024) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2816865 /Source="Nicolas_upshifts" /id="D1679" /incds=0 /nref=35 /ntot=74 /MaxReadThrough="0.613989999999999" /MaxDrop="8.59238" /score="-3.31011906" /energy="-20" /TU="NA" /idTUdmin="U2538" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2816901..2817665) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12662922, 23388828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 23388828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein required for membrane fission during spore formation" /protein_id="NP_391115.1" /db_xref="EnsemblGenomes-Gn:BSU32350" /db_xref="EnsemblGenomes-Tr:CAB15225" /db_xref="GOA:O32131" /db_xref="InterPro:IPR014197" /db_xref="SubtiList:BG13976" /db_xref="UniProtKB/Swiss-Prot:O32131" /translation="MPRYRGPFRKRGPLPFRYVMLLSVVFFILSTTVSLWMINGSIKP VLMDIGEMETKRIATEVIQDSIEDYMSDSENMKDMFQMNSDENGNLTTIDFNTQVVNS VKTKVTKQLQAHLKEMETHTGHSGASENIMINIPLGQVTGNSLLGNLGPKIPVRFNLI GDAFTDVKTKIKPYGINNALIDISIFVEIKVKVIIPFASKTAVVTNNVPVSIKAVQGE VPQFYNGSGGSGVTPSVQLPSSKENGADSKKEKSSK*" /label="fisB CDS" gene complement(2816901..2817665) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /label="fisB gene" downshifts complement(2816917) /Source="Nicolas_upshifts" /id="D1680" /incds=0 /nref=74 /ntot=226 /MaxReadThrough="3.15258" /MaxDrop="6.53891" /score="23.5286262" /energy="-12.4" /TU="NA" /idTUdmin="U2540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2817679..2817697) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2817687) /Source="Nicolas_upshifts" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2817713..2817718) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2817738..2818043) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391116.1" /db_xref="EnsemblGenomes-Gn:BSU32360" /db_xref="EnsemblGenomes-Tr:CAB15226" /db_xref="InterPro:IPR014931" /db_xref="InterPro:IPR036493" /db_xref="SubtiList:BG13977" /db_xref="UniProtKB/Swiss-Prot:O32132" /translation="MVNLTPIMIEGQPFTAVTVKLPKTNFMAVANDHGYIMCGALDVA LLNEKLKERGIVAGRAVGVRTIDQLLDAPLESVTYAAEDLGIKVGMSGREALLKMMK* " /label="yunC CDS" gene complement(2817738..2818043) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /label="yunC gene" downshifts complement(2817746) /Source="Nicolas_upshifts" /id="D1681" /incds=0 /nref=3 /ntot=128 /MaxReadThrough="5.18714" /MaxDrop="3.9347" /score="-2.65376612" /energy="-18.9" /TU="U2541,U2543,U2544" /idTUdmin="U2540" /TUdmin="-829" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2818057..2818076) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2818080) /Source="Nicolas_upshifts" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2818090..2818098) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2818108..2819496) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nuclease/nucleotidase/phosphoesterase" /protein_id="NP_391117.1" /db_xref="EnsemblGenomes-Gn:BSU32370" /db_xref="EnsemblGenomes-Tr:CAB15227" /db_xref="GOA:O32133" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR011240" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG13978" /db_xref="UniProtKB/Swiss-Prot:O32133" /translation="MKEKLRLYHTNDLHSHFENWPKIVDYIEQKRKEHQSDGEETLVF DIGDHLDRFQFVTEATFGKANVDLLNRLHIDGAAIGNNEGITLPHEELAALYDHAEFP VIVSNLFDKNGNRPSWAVPYHIKSLKNGMSIAFLGVTVPYYPVYDKLGWTVTDALESI KETILEVKGQADIIVLLSHLGILDDQAVAEAVPEIDVILESHTHHLLEDGQVVNGVLL ASAEKYGHYVGCVEITVDSVQRSINSKTASVQNMAEWTGESAETKAFLNEKEREAEEK LSDAVAELAQDAEVKWFEESELPLLLAYALKEWCETDISMVNSGVILGPLKAGPVTKL DLHRICPHPINPVAVRLTGEELKETIVHAASEQMEQLRIKGLGFRGEVMGKMVYAGVE VETKRLDDGITHVTRITLNGEDIEKHKQYSVAVLDMFTLGKLFPLIRDAAEKEYFMPE FLRDLLAWKLAQ*" /label="yunD CDS" gene complement(2818108..2819496) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /label="yunD gene" CDS complement(2819516..2820337) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391118.1" /db_xref="EnsemblGenomes-Gn:BSU32380" /db_xref="EnsemblGenomes-Tr:CAB15228" /db_xref="GOA:O32134" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13979" /db_xref="UniProtKB/Swiss-Prot:O32134" /translation="MSFVILVVLGLIAGTVGSLIGLGGGIVIVPSLMFLSTVTQLFQD VTPQVAIGTSLLVIIFTGLSSTLAYIKYKTVDYKSGLIFFIGSGPGSMIGAYVSKLFN SNSFSVWFGIFMILISLSLMLKAKARPINKAHKGIIRTFQDDAGEPYTYSYQASVGIA IAFVVGFLGGLFGIGGGSLMVPAMMLLFLFPPKVAVATSMFIIFLSSMTGSVSHMISG HVNWLYALALVPGAWFGGKLGAAINRKMQTKTIVMIMRIVLILIGCQLIYEGIFS*" /label="yunE CDS" gene complement(2819516..2820337) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /label="yunE gene" CDS complement(2820355..2821203) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391119.2" /db_xref="EnsemblGenomes-Gn:BSU32390" /db_xref="EnsemblGenomes-Tr:CAB15229" /db_xref="InterPro:IPR002763" /db_xref="InterPro:IPR036520" /db_xref="SubtiList:BG13980" /db_xref="UniProtKB/Swiss-Prot:O32135" /translation="MIYIGLTGWGDHDSIYPPKTASQKKLQAYSSHFPIVELDASFYA IQPARNNEKWVKETPETFQFIVKAYQGMTGHQRGEIPFDSKEEMFDAFKVSLTPYLHS NKLAMVLFQFPPWFDCKKENVAYLRWCKHQMGDIPCALEFRNRSWFSPPFYEQTLSFM KAEGWIHSVCDEPQIGEGSVPTVLRATDENKTLVRFHGRNKQGWMKPDGGKNWREVRY LYRYNQQELEDWKKHLNELQQQCKDVFVLFNNNSGGDAADNGKQMLELLDIEYSGLAP RQLDLF*" /label="yunF CDS" gene complement(2820355..2821203) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /label="yunF gene" promotor_-35 2820722..2820727 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2820743..2820761 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2820757 /Source="Nicolas_upshifts" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2821214..2821233) /Source="Nicolas_upshift_promotors" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2821229) /Source="Nicolas_upshifts" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2821241..2821588) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391120.1" /db_xref="EnsemblGenomes-Gn:BSU32400" /db_xref="EnsemblGenomes-Tr:CAB15230" /db_xref="SubtiList:BG13981" /db_xref="UniProtKB/Swiss-Prot:O32136" /translation="MEHVKYILKQSWSRHSSSKWTEECPSCGQCGVTALVIQDHFGGT IFKTRVDESWHFYNSINGVVYDFTSEQFQAPIEYQHIPSSREEAFLDTNEEQYQHLRE AFSRHMNSISEET*" /label="yunG CDS" gene complement(2821241..2821588) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /label="yunG gene" promotor_-10 complement(2821601..2821620) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2821620) /Source="Nicolas_upshifts" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2821634..2821640) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2821685..2823025) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /EC_number="3.5.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoinase" /protein_id="NP_391121.1" /db_xref="EnsemblGenomes-Gn:BSU32410" /db_xref="EnsemblGenomes-Tr:CAB15231" /db_xref="GOA:O32137" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR017593" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13982" /db_xref="UniProtKB/Swiss-Prot:O32137" /translation="MAYDMVIKGAKAVTPDGVIEADIVVQNGVIAEIGSDIEASGTEI IQADGKYVFPGVIDCHVHFNEPGREDWEGFETGSQMMAAGGCTTYFDMPLNCIPSTVT AEHLLAKAELGRQKSAVDFALWGGLVPGHIEDIRPMAEAGAIGFKAFLSKSGTDEFRS VDERTLLKGMAEIAAAGKILALHAESDAITSYLQMVLANKGKVDADAYAASRPEEAEV EAVYRTIQYAKVTGCPVHFVHISTAKAVRLIREAKQEGLDVSVETCPHYVLFSHDDLR QRGSVAKCAPPLRSRQSKETLIETLIAGDIDMVSSDHSPCRPSLKREDNMFLSWGGIS GGQFTLLGMLELALEHQIPFETIAEWTAAAPAKRFGLQKKGRLEAGCDADFVLVSMEP YTVTRESMFAKHKKSIYEGHTFPCSISATYSKGRCVYNDGEKVTEIDGALVVPS*" /label="pucH CDS" gene complement(2821685..2823025) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /label="pucH gene" downshifts complement(2821713) /Source="Nicolas_upshifts" /id="D1682" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.88847" /MaxDrop="3.89144" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-4796" /isTUend="FALSE" /label="downshifts" downshifts complement(2822769) /Source="Nicolas_upshifts" /id="D1683" /incds=1 /nref=1 /ntot=7 /MaxReadThrough="3.38784" /MaxDrop="3.36547" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-5852" /isTUend="FALSE" /label="downshifts" promotor_-35 2823082..2823088 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2823102..2823121 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2823104..2823122) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2823110 /Source="Nicolas_upshifts" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2823111..2823199 /Source="Nicolas_S_feature" /locus_tag="new_3328673_3328761" /HighExp="BT, Cold, S0, LBGexp, S1, Lbtran, G150, T-1.40H, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S1250" upshifts complement(2823121) /Source="Nicolas_upshifts" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2823138..2823143) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2823200..2824795 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 12374841" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 12374841; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine degradation operon" /protein_id="NP_391122.1" /db_xref="EnsemblGenomes-Gn:BSU32420" /db_xref="EnsemblGenomes-Tr:CAB15232" /db_xref="GOA:O32138" /db_xref="InterPro:IPR012914" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG13983" /db_xref="UniProtKB/Swiss-Prot:O32138" /translation="MNILDVMKIPAFENANLIAGKAGGEREVQHVNMMDAPDIVDFLH KNELLVTTAYHLKDHPHQLSELIRQMAKRGCAGLGIKTKRYLEDIPKEIIELADSYAF PIIELPEHIRLGDIVNATLSHILDMRSNELQQAIYAHKKFTNHIMSGKGLQSLLKKVS DILQLPVLLLDQHAKMLSASHQISVETEKLKGTLNTVSGPFFTCFSTISDQKTYSVLP IYNHEKNCGYLLIPDMVQAGDKGLILTIEQAANVISFELLKENALKQFSRRARNEFFN NFIERTFSSDDEIKNRAKEFKLRWDQKYMCIAGKLDRNDESISFTENQLASDSVFEFL EGELSAFPFPPHFFMKGNVGIILIEATDSWSEMHASVISFLEQFQTQVSAQFKRTVSF GISNICQKLIDVPDAFTEASDALQSGHLSRSTAFIQVYHAKDVPELLRLLPVEDLKKF YNSTLQSLAEKQQEDQSLLHTLSVYLETHCQISETAKRLYVHRNTVIYRLEKCEELLG KSLKDPETTMRLRLALRMQRLIS*" /label="pucR CDS" gene 2823200..2824795 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /label="pucR gene" CDS 2824940..2826289 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease" /protein_id="NP_391123.1" /db_xref="EnsemblGenomes-Gn:BSU32430" /db_xref="EnsemblGenomes-Tr:CAB15233" /db_xref="GOA:O32139" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13984" /db_xref="UniProtKB/Swiss-Prot:O32139" /translation="MKKRSFKVFTLSLQHVLAMYAGAILVPLLVGRALNVTTEQLSYL LAIDLLTCGVATLLQTLRGTYIGIGLPVMLGSSFVAVTPMIAIGSNYGIHAIYGSIIA AGVFIFLFARFFGKLTVLFPPVVTGTVVTLIGLSLVPTGVKNMAGGEKINGSANPEYG SLENLLLSVGVLVLILVLNRFLKGFARTLSVLIGIAAGTAAAAIMGKVSFSSVTEAPF FQIPKPFYFGAPAFEIGPILTMLIVGIVIIVESTGVFYAIGKICGRPLTDKDLVKGYR AEGIAILIGGLFNAFPYNTFAQNAGLLQLTKVKTRNIVVTAGCILVCLGLIPKIAALA SAVPAAVLGGATVVMFGMVIASGVKMLSTADLKNQYHLLTIACSIALGIGASTAPGIF AEFPAPIRILVSDGTITGSLTAIFLNLFFSLRDKKELTAQQTELPVLEHTLALEKEV* " /label="pucJ CDS" gene 2824940..2826289 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /label="pucJ gene" CDS 2826295..2827587 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease subunit" /protein_id="NP_391124.1" /db_xref="EnsemblGenomes-Gn:BSU32440" /db_xref="EnsemblGenomes-Tr:CAB15234" /db_xref="GOA:O32140" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13985" /db_xref="UniProtKB/Swiss-Prot:O32140" /translation="MKEQHNALQLMMLGLQHMLAMYAGAILVPLIVGAAIGLNAGQLT YLIAIDLFMCGAATLLQLWRNRYFGIGLPVVLGCTFTAVGPMISIGSTYGVPAIYGAI IAAGLIVVLAAGFFGKLVRFFPPVVTGSVVMIIGISLIPTAMNNLAGGEGSKEFGSLD NVLLGFGVTAFILLLFYFFKGFIRSIAILLGLIAGTAAAYFMGKVDFSEVLEASWLHV PSLFYFGPPTFELPAVVTMLLVAIVSLVESTGVYFALADITNRRLSEKDLEKGYRAEG LAILLGGLFNAFPYTAFSQNVGIVQLSKMKSVNVIAITGIILVAIGLVPKAAALTTVI PTPVLGGAMIVMFGMVISYGIKMLSSVDLDSQGNLLIIASSVSLGLGATTVPALFSSL SGAASVLAGSGIVIGSLTAIALHAFFQTKQPNSADIKT*" /label="pucK CDS" gene 2826295..2827587 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /label="pucK gene" CDS 2827600..2829084 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /EC_number="1.7.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12823818, 17567580, 20168977, 23760935, 28531234" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12823818, 17567580, 20168977, 23760935, 28531234; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="urate oxidase with peroxide reductase N-terminaldomain" /protein_id="NP_391125.1" /db_xref="EnsemblGenomes-Gn:BSU32450" /db_xref="EnsemblGenomes-Tr:CAB15235" /db_xref="GOA:O32141" /db_xref="InterPro:IPR002042" /db_xref="InterPro:IPR017580" /db_xref="InterPro:IPR018020" /db_xref="InterPro:IPR019842" /db_xref="InterPro:IPR036778" /db_xref="SubtiList:BG13986" /db_xref="UniProtKB/Swiss-Prot:O32141" /translation="MFTMDDLNQMDTQTLTDTLGSIFEHSSWIAERSAALRPFSSLSD LHRKMTGIVKAADRETQLDLIKKHPRLGTKKTMSDDSVREQQNAGLGKLEQQEYEEFL MLNEHYYDRFGFPFILAVKGKTKQDIHQALLARLESERETEFQQALIEIYRIARFRLA DIITEKGETQMKRTMSYGKGNVFAYRTYLKPLTGVKQIPESSFAGRDNTVVGVDVTCE IGGEAFLPSFTDGDNTLVVATDSMKNFIQRHLASYEGTTTEGFLHYVAHRFLDTYSHM DTITLTGEDIPFEAMPAYEEKELSTSRLVFRRSRNERSRSVLKAERSGNTITITEQYS EIMDLQLVKVSGNSFVGFIRDEYTTLPEDGNRPLFVYLNISWQYENTNDSYASDPARY VAAEQVRDLASTVFHELETPSIQNLIYHIGCRILARFPQLTDVSFQSQNHTWDTVVEE IPGSKGKVYTEPRPPYGFQHFTVTREDAEKEKQKAAEKCRSLKA*" /label="pucL CDS" gene 2827600..2829084 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /label="pucL gene" CDS 2829084..2829428 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /EC_number="3.5.2.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 16098976, 16782815, 21795808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 16098976, 16782815, 21795808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-hydroxyisourate hydrolase; also uricase subunit" /protein_id="NP_391126.2" /db_xref="EnsemblGenomes-Gn:BSU32460" /db_xref="EnsemblGenomes-Tr:CAB15236" /db_xref="GOA:O32142" /db_xref="InterPro:IPR000895" /db_xref="InterPro:IPR014306" /db_xref="InterPro:IPR023416" /db_xref="InterPro:IPR023418" /db_xref="InterPro:IPR023419" /db_xref="InterPro:IPR036817" /db_xref="PDB:2H0E" /db_xref="PDB:2H0F" /db_xref="PDB:2H0J" /db_xref="SubtiList:BG13987" /db_xref="UniProtKB/Swiss-Prot:O32142" /translation="MGKLTTHILDLTCGKPAANVKIGLKRLGESIMKEVYTNNDGRVD VPLLAGEELMSGEYVMEFHAGDYFASKNMNAADQPFLTIVTVRFQLADPDAHYHIPLL LSPFGYQVYRGS*" /label="pucM CDS" gene 2829084..2829428 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /label="pucM gene" promotor_-35 2829150..2829153 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2829171..2829190 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2829183 /Source="Nicolas_upshifts" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2829403 /Source="Nicolas_upshifts" /id="D1684" /incds=0 /nref=3 /ntot=90 /MaxReadThrough="1.80149" /MaxDrop="3.57243" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2547" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2829444..2829831) /Source="Nicolas_S_feature" /locus_tag="new_3335006_3335393_c" /HighExp="BT, S8, T2.0H, LBGstat, Cold, Etha, Sw, T1.0H, T1.30H, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1251" promotor_-35 2829791..2829800 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2829813..2829832 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2829816 /Source="Nicolas_upshifts" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="upshifts" ncRNA complement(2829852..2829983) /ncRNA_class="antisense_RNA" /gene="auzJ" /locus_tag="BSU_ncRNA_2" /product="putative antisense RNA for type I YuzJ toxin" /note="Evidence 3: Putative function from multiple computational evidences" /label="auzJ ncRNA" CDS 2829852..2829983 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 20525796, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097780.1" /db_xref="EnsemblGenomes-Gn:BSU32469" /db_xref="EnsemblGenomes-Tr:CAX52686" /db_xref="GOA:C0H3Q7" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Q7" /translation="MGFYNSGGYSGNSGYSNGFGSSFALIVVLFILLIIVGAAIFNY* " /label="yuzJ CDS" gene 2829852..2829983 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /label="yuzJ gene" gene complement(2829852..2829983) /gene="auzJ" /locus_tag="BSU_ncRNA_2" /label="auzJ gene" S_feature 2829984..2830052 /Source="Nicolas_S_feature" /locus_tag="new_3335546_3335614" /HighExp="BT, B36, S8, G/S, B60, Pyr, Glucon, C30, S7, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1252" downshifts 2830019 /Source="Nicolas_upshifts" /id="D1685" /incds=0 /nref=10 /ntot=25 /MaxReadThrough="0.61379" /MaxDrop="6.43101" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2548" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2830189..2830710) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, iron-sulfur subunit" /protein_id="NP_391127.1" /db_xref="EnsemblGenomes-Gn:BSU32470" /db_xref="EnsemblGenomes-Tr:CAB15237" /db_xref="GOA:O32143" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR002888" /db_xref="InterPro:IPR006058" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017611" /db_xref="InterPro:IPR036010" /db_xref="InterPro:IPR036884" /db_xref="SubtiList:BG13988" /db_xref="UniProtKB/Swiss-Prot:O32143" /translation="MDIKEAGPFPVKKEQFRMTVNGQAWEVAAVPTTHLSDLLRKEFQ LTGTKVSCGIGRCGACSILIDGKLANACMTMAYQADGHSITTIEGLQKEELDMCQTAF LEEGGFQCGYCTPGMIIALKALFRETPQPSDKDIEEGLAGNLCRCTGYGGIMRSACRI RRELNGGRRESGF*" /label="pucE CDS" gene complement(2830189..2830710) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /label="pucE gene" CDS complement(2830701..2832938) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, substrate and molybdenumcofactor subunit" /protein_id="NP_391128.1" /db_xref="EnsemblGenomes-Gn:BSU32480" /db_xref="EnsemblGenomes-Tr:CAB15238" /db_xref="GOA:O32144" /db_xref="InterPro:IPR000674" /db_xref="InterPro:IPR008274" /db_xref="InterPro:IPR017609" /db_xref="InterPro:IPR036856" /db_xref="InterPro:IPR037165" /db_xref="SubtiList:BG13989" /db_xref="UniProtKB/Swiss-Prot:O32144" /translation="MIINKPSRVRPDGRGKVTGELKYMTDLSFPGMLYGKVLRSAYPH AEIVSVCTIKAEKMEGVQAVVTHKDVPGLNRFGIVIPDQPVLCEDRVRYVGDAIAAVA AETEEIAEAALELIQVEYKELEVMDSPEKALRPNAQRLHEDGNILHRAFFSNGDVEEG FQASDTVFEETYELPRQMHTYMETEGGVAVPEDDGGFTMYAGTQHGYKDRFQLARIFD IPEEKIRIVSSPMGGSFGGKDELNIQPYAALLALKSGRPVKIHQTRKESVRSGIKRHP MKITIKTGADHSGNLLAHDVKIVADTGAYATLGPAVLDFSVEHAAGPYRIPNIRTEGI SVFTNNGVAGEFRGFGGNQITFALETHLDRLSGMLGIDPLELRRKNIRKPHDLGPLEH RIAPTDGAAQVLNAISKSPILKKTSRNCGYLQRGTGAAITMHGGGLGFGRMDAAGGRL SLSSEGKITASFGFEECGQGILAAIEQIVMEELGCAAEDISIVIGDTAKVPKSGSSTA SRGTSMVWHAIQRLKKPFLAQLKKRAAEWSGCSAENLIPGAAGLRDKNTKALVVTYKE LAEKGPLAEETAFDFPTTPDPVVGGHFLYSFGAAAVEVEVDLLTGDVKLIDCEHAIAA GPVVSPQGYRGQIEGGAAMALGYTLMEEAKMTDGRYAAENLDHYLIPGIKDVPDMKLI AIEDLMKGDVYGPRGVGEIGTIAITPAIVKAVHDAVGCWINKLPISREELLEAIDRKG LKQWT*" /label="pucD CDS" gene complement(2830701..2832938) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /label="pucD gene" CDS complement(2832939..2833772) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, FAD-binding subunit" /protein_id="NP_391129.1" /db_xref="EnsemblGenomes-Gn:BSU32490" /db_xref="EnsemblGenomes-Tr:CAB15239" /db_xref="GOA:O32145" /db_xref="InterPro:IPR002346" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR017612" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036683" /db_xref="SubtiList:BG13990" /db_xref="UniProtKB/Swiss-Prot:O32145" /translation="MNGQVTKARMNIQLWRPAALDEAYSLLEKLAPDVCAASGSTLLQ LQWDKGTLPKQHLVSLEGIDEMRGISTSDTHVSIGGLTSLNECRKNPLIKRALSCFSD AASAVAAPGIRSRATIGGNIASKIGDFIPLLLVLGAELIVYQKELIRLPLGAWLSEED FRTAIVTRVIIPRAEGERVFYHKLGRRQAFTGAAAVAAGRFLKDGSIRLAAGHADITP RRLLDSEAKWMAPGWDPHELYKTLIHELPFSSDVFMSAAYRKKAAANVIMAELMAEGG E*" /label="pucC CDS" gene complement(2832939..2833772) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /label="pucC gene" CDS complement(2833769..2834386) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /EC_number="2.7.7.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11344136, 21528011; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin cofactor synthesis cytidylyl transferase" /protein_id="NP_391130.2" /db_xref="EnsemblGenomes-Gn:BSU32500" /db_xref="EnsemblGenomes-Tr:CAB15240" /db_xref="GOA:O32146" /db_xref="InterPro:IPR017615" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13991" /db_xref="UniProtKB/Swiss-Prot:O32146" /translation="MRSPYLIGVFLAAGKSRRMGQNKLALPLKGENIGSLSLKTALSS RLDHVLVVERTEHASLEWIGAPYHAPPFQKRWSLHVCQDAEKGQGHSVSSGVRKAESM GADGIVILLADQPQLSVDHLNALVALAPESFAVSSFLGAFTPPIYFSSTCFPYVKGLK GDEGARRLLKSGQLGAGAVLEAKDSGELDDIDTPEEYDMVRRAMS*" /label="pucB CDS" gene complement(2833769..2834386) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /label="pucB gene" downshifts complement(2833878) /Source="Nicolas_upshifts" /id="D1686" /incds=1 /nref=3 /ntot=13 /MaxReadThrough="5.34639" /MaxDrop="3.22355" /score="-4.87239629" /energy="-9.9" /TU="U2549" /idTUdmin="U2549" /TUdmin="-3827" /isTUend="FALSE" /label="downshifts" CDS complement(2834383..2835375) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10217763, 11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217763, 11344136, 12029039; Product type f: factor" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase molybdopterin recruitmentfactor" /protein_id="NP_391131.1" /db_xref="EnsemblGenomes-Gn:BSU32510" /db_xref="EnsemblGenomes-Tr:CAB15241" /db_xref="GOA:O32147" /db_xref="InterPro:IPR003777" /db_xref="InterPro:IPR027051" /db_xref="SubtiList:BG13992" /db_xref="UniProtKB/Swiss-Prot:O32147" /translation="MGNFHTMLDALLEDQEEAVLATIVQVEGSAYRKAGASMLFKKKG RRIGLLSGGCVEEDVFQRISALGDQLTSTLIPYDMRSEDDLSWGMGAGCNGIIHVHAE RITQEKRRHYEKVRDCLHSGKAVTSVIKIESSHYLFLTENGHFGNWPDAPLQDIQRTV STLHLPHFDQTTNMFIQRIEPKPRLILFGAGPDNVPLANLAADTGFSVIVTDWRPAYC TSSLFPKADQLITAFPEQMLSEFQFFPHDAAVVATHHYQHDQTIINFLFSQNLHYIGL LGSANRTKRLLSGKHPPSHFYSPVGLKIGAEGPEEIAVSVVAEIIQTRKRVAVV*" /label="pucA CDS" gene complement(2834383..2835375) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /label="pucA gene" S_feature complement(2835376..2835462) /Source="Nicolas_S_feature" /locus_tag="new_3340938_3341024_c" /HighExp="BT, Cold, Sw, T-1.10H, S1, C30, S0, T-0.40H, T-3.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.607" /TUlongSig="NA" /TUlongPSig="NA" /label="S1253" promotor_-10 complement(2835440..2835459) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2835462) /Source="Nicolas_upshifts" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2835473..2835478) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2835604..2836854) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 20852637, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 20852637, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(S)-ureidoglycine-glyoxylate aminotransferase (PLP-dependent)" /protein_id="NP_391132.1" /db_xref="EnsemblGenomes-Gn:BSU32520" /db_xref="EnsemblGenomes-Tr:CAB15242" /db_xref="GOA:O32148" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR024169" /db_xref="PDB:3ISL" /db_xref="SubtiList:BG13993" /db_xref="UniProtKB/Swiss-Prot:O32148" /translation="MSGRRELCTPLRTIMTPGPVEVDPRVLRVMSTPVVGQFDPAFTG IMNETMEMLRELFQTKNRWAYPIDGTSRAGIEAVLASVIEPEDDVLIPIYGRFGYLLT EIAERYGANVHMLECEWGTVFDPEDIIREIKKVKPKIVAMVHGETSTGRIHPLKAIGE ACRTEDALFIVDAVATIGGCEVKVDEWKIDAAIGGTQKCLSVPSGMAPITYNERVADV IAARKKVERGIATQADRAALSGNRPITSNYFDLSQLEDYWSERRLNHHTEATTMLYAL REGVRLVLEEGLETRFERHRHHEAALAAGIKAMGLRLFGDDSCKMPVVTCVEIPGGID GESVRDMLLAQFGIEIASSFGPLAGKIWRIGTMGYSCRKENVLFVLAGLEAVLLRHNA GIEAGKALQAALDVYENAGRQAAV*" /label="pucG CDS" gene complement(2835604..2836854) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /label="pucG gene" CDS complement(2836871..2838109) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /EC_number="3.5.3.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11344136, 17362992, 25020232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoate amidohydrolase" /protein_id="NP_391133.1" /db_xref="EnsemblGenomes-Gn:BSU32530" /db_xref="EnsemblGenomes-Tr:CAB15243" /db_xref="GOA:O32149" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010158" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13994" /db_xref="UniProtKB/Swiss-Prot:O32149" /translation="MEKQKLSVKNSITDYIEWLAQYGASADGGVTRLLYTKEWMDAQL AVKTEMSSFGLETRFDDVGNVFGRLSGTQSPDEVIVTGSHIDTVINGGKYDGAYGVLA AMLALKQLKETYGAPKKTLEAVSLCEEEGSRFPMTYWGSGNMTGVFSEQDAKEPRDES GVSLQTAMHESGFGKGVFQSAYRTDISAFVELHIEQGKTLEMSGRDLGIVTSIAGQRR YLVTLEGECNHAGTTSMKWRKDPLAASSRIIHELLLRSDELPDELRLTCGKITAEPNV ANVIPGRVQFSIDIRHQHQHVLEQFHQDMVALINGICLQKGIRAVIDEYMRIEPVPMD ERLKAAAFETALENGFSCEEMVSGAGHDAQMIGRRYPACMLFVPSRGGVSHSPKEYTS ARQLEIGVRALTDLLYKLAY*" /label="pucF CDS" gene complement(2836871..2838109) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /label="pucF gene" CDS 2838332..2838469 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514002.1" /translation="MNKLSWRGDVRGTDENRNAGSPQKQDLKIWKQEISASSKGTNLQ F*" /label="hypothetical protein CDS" gene 2838332..2838469 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /label="gene" promotor_-35 2838491..2838494 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2838509..2838528 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2838510 /Source="Nicolas_upshifts" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="upshifts" CDS 2838551..2839417 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1396690, 12490701, 12883447, 16291680, 25844442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1396690, 12490701, 12883447, 16291680, 25844442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular ribonuclease" /protein_id="NP_391134.1" /db_xref="EnsemblGenomes-Gn:BSU32540" /db_xref="EnsemblGenomes-Tr:CAB15244" /db_xref="GOA:O32150" /db_xref="InterPro:IPR007346" /db_xref="SubtiList:BG13995" /db_xref="UniProtKB/Swiss-Prot:O32150" /translation="MTKKAWFLPLVCVLLISGWLAPAASASAQTTLSLNDRLASSPSG TGSLLSLAAPAAPYADTDTYYEGAEGKTGDSLKSTLHRIISGHTMLSYSEVWNALKET DEDPRNPNNVILLYTNESRSKNLNGGNVGDWNREHVWAKSHGDFGTSKGPGTDIHHLR PADVQVNSARGNMDFDNGGTEYAKAPGNYYDGDSWEPRDDVKGDVARMLFYMAVRYEG DDGYPDLELNDKTGNGSAPYHGKQSVLLEWNKQDPVDDRERKRNEIIYEKYQHNRNPF IDHPEWADEIWP*" /label="bsnA CDS" gene 2838551..2839417 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /label="bsnA gene" downshifts 2839420 /Source="Nicolas_upshifts" /id="D1687" /incds=0 /nref=48 /ntot=190 /MaxReadThrough="0.45317" /MaxDrop="6.90997" /score="25.7790712" /energy="-15.5" /TU="NA" /idTUdmin="U2550" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(2839451..2840554) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23175651, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23175651, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid ABC transporter (ATP-bindingsubunit)" /protein_id="NP_391135.1" /db_xref="EnsemblGenomes-Gn:BSU32550" /db_xref="EnsemblGenomes-Tr:CAB15245" /db_xref="GOA:O32151" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR013611" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13996" /db_xref="UniProtKB/Swiss-Prot:O32151" /translation="MASLTFEHVKKSYHSQLTVKDFDLDVKDKELLVLVGPSGCGKST TLRMVAGLESISEGNLLIDGERVNDLPPKERDIAMVFQNYALYPHMTVFDNMAFGLKL RKMAKQEIAERVHAAARILEIEHLLKRKPKALSGGQRQRVALGRSIVREPKVFLMDEP LSNLDAKLRVTMRTEISKLHQRLEATIIYVTHDQTEAMTMGDRIVVMNEGEIQQVAKP HDIYHYPANLFVAGFIGSPGMNFLKGIIEQQHGELFFTNSSIRLHIPEEKAKRLKEKG YAGEQMIAGVRPEHITQMTGNDQLFDSVFQANVEVNENLGSELIVHVMAGDERLKVRL DGNTRIDAGDSIQLSVKMDHVVFFDAETEEAVY*" /label="frlP CDS" gene complement(2839451..2840554) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /label="frlP gene" downshifts complement(2839466) /Source="Nicolas_upshifts" /id="D1688" /incds=0 /nref=57 /ntot=215 /MaxReadThrough="3.04361" /MaxDrop="6.06171" /score="29.1144499" /energy="-15.5" /TU="NA" /idTUdmin="U2553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2840555..2841488) /Source="Nicolas_S_feature" /locus_tag="new_3346117_3347050_c" /HighExp="HiOs, T-5.40H, T5.0H, GM-0.1, S2, GM-0.2, GM 5, T-4.40H, T4.0H, SMM" /AntisenseName="frlR" /AntisenseCor="0.22682293682100099" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.971, 0.456, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1254" promotor_-35 2840592..2840599 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2840613..2840632 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2840623 /Source="Nicolas_upshifts" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2840674..2840680 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2840691 /Source="Nicolas_upshifts" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2840695..2840714 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2840736..2841464 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /experiment="publication(s) with functional evidences, PMID:21347729, 21398478, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21347729, 21398478, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FrlR transcriptional regulator (GntR family)" /protein_id="NP_391136.3" /db_xref="EnsemblGenomes-Gn:BSU32560" /db_xref="EnsemblGenomes-Tr:CAB15246" /db_xref="GOA:O32152" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2IKK" /db_xref="SubtiList:BG13997" /db_xref="UniProtKB/Swiss-Prot:O32152" /translation="MLNNGSSTPLYIQLKQIITDDIKKGVYSPTAKLPTENELCTKYN VSRITVRKAILDLVEEGYLIRQQGKGTFVKSPKLKRELIAVNGYSEFMESTGKKPKHH VLSHDIIPASKPIAEKLQIQPESPVVELKRILYNDDQPLTFEVTHYPLDLFPGIDTFI ADGVSMHDILKQQYKVVPTHNTKLLNVVYAQQEESKYLDCDIGDALFEIDKTAFTSND QPIYCSLFLMHTNRVTFTINSPYT*" /label="frlR CDS" gene 2840736..2841464 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /label="frlR gene" CDS complement(2841489..2842343) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 14641112, 15556630, 16153181, 21347729, 21398478, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fructoselysine kinase" /protein_id="NP_391137.1" /db_xref="EnsemblGenomes-Gn:BSU32570" /db_xref="EnsemblGenomes-Tr:CAB15247" /db_xref="GOA:O32153" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13998" /db_xref="UniProtKB/Swiss-Prot:O32153" /translation="MKLIAVGDNVVDYYQDQETFYPGGNALNVAVLAKRLGHESSYIG IVGNDEAAAHLLNVLKLEQVNADYIRQAHGENGMAIVTLDEQGDRIFVRSNKGGIQSR LRLAFQEKDVSFISGHDLLHTSVYSRLENDLPQLCGLVPVSFDFSTNREDDYLRRVCP YVTYAFFSGSDLSESECGELAKTAHGYGAKMVCMTRGGQGAILSAGDRVYHQPIVEAD IIDTLGAGDSFIAGFLTAFCVKQDITYALRQAAETAAKTCGVYGAFGYGYPYRLEDGG SSEKTRIL*" /label="frlD CDS" gene complement(2841489..2842343) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /label="frlD gene" misc_feature complement(2841676..2841695) /Source="Nicolas_upshift_promotors" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2841688) /Source="Nicolas_upshifts" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2841846..2841946) /Source="Nicolas_upshift_promotors" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2841886) /Source="Nicolas_upshifts" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2842357..2843259) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391138.1" /db_xref="EnsemblGenomes-Gn:BSU32580" /db_xref="EnsemblGenomes-Tr:CAB15248" /db_xref="GOA:O32154" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13999" /db_xref="UniProtKB/Swiss-Prot:O32154" /translation="MLPQKKTDSFRLEPVPDQHIEVKDKPRRKWYIGETSVWVFLFLY LIAIAYPLLWMVMSAFKNSDDIFEHSWSLPSSWHPENFVSAWNQGISSYFMNSVIVTA LTCVITVFISAWAAYGLSRFEFKGKGFFLVLCLGGLMLTPQVSLVPLYSIIQSLGLYN TYWALILPYAAYRIPFTIILIRSYFLSISKELEEAAYLDGCTSFGVFFRIFLPMSVPI LVTSGILTAYHTWNEFMFAIIFIDDENLRTIPAGLMQFRDALQTDWGVLLAGLTISAA PIIILFLLMQKYFVRGIASGSVKG*" /label="frlM CDS" gene complement(2842357..2843259) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /label="frlM gene" CDS complement(2843263..2844141) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391139.1" /db_xref="EnsemblGenomes-Gn:BSU32590" /db_xref="EnsemblGenomes-Tr:CAB15249" /db_xref="GOA:O32155" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14000" /db_xref="UniProtKB/Swiss-Prot:O32155" /translation="MVNQNKIIPYLFLVPALVFLLFVYIPIFENVFLSLFQWSSFSPE KTFIGLKNYVELFHDPVFYQALTNNVLYAVISIVCQVFGGLILAAVLEDKLVRKWSPF FRTVFFLPVVISMTVIALLFDFIYNPETGLLNQLLQAIGLDQLTRAWLGDDSTAMLSV IFVSQWQSVGYIAMLYIVSIQKIPDELYEAARLDGAGKIQQFFHITVPQTKEMSFVAV VMTLTGAFTVFNEPYILTGGGPGKASEVLSTFLYKSAFTKDMMGYASAIATVVLIITL ALSLMQMKFFKTGKEE*" /label="frlN CDS" gene complement(2843263..2844141) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /label="frlN gene" CDS complement(2844199..2845467) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 21347729; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose amino acid-binding lipoprotein" /protein_id="NP_391140.1" /db_xref="EnsemblGenomes-Gn:BSU32600" /db_xref="EnsemblGenomes-Tr:CAB15250" /db_xref="GOA:O32156" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG14001" /db_xref="UniProtKB/Swiss-Prot:O32156" /translation="MKKMLLFLIIAAVSMLTIAGCSSQSSSADGKVTLKFFHRWPKEP EKSYFEEVVKEFEKDHPDIDIQIEAVLNDSYKDKIKVMLGTTSPPDIYFSWSDEFAFK FIRGNKALDLSSYYKNDTDWSSQLVQSQITPFTYENKQYGVPWQMDAKSFFYNKDIFQ KLNLDPPKTWDELIDVSKKLKEHGYTPISFGTKATWTISHYIGTLNQRMVDEKTREKD YNAKTGEFTDEGYVKALEKLQELMPYFNKHVNSVDHEYVRQQFKSGKSAMIYAETAEI KLVEPVNLGMFPFPEISGQKGSSEALTGAPEGFMISSRTKHPKEAMEFLQFLTSKRMG EKLVKDVGKYSAVQGTATEENATAIQREAVQHIVDAKSMVPWFDMDVDVEVADAYLTG VQQMLGGDMTPQQVMKAVQKAAKQVRASAE*" /label="frlO CDS" gene complement(2844199..2845467) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /label="frlO gene" promotor_no_box 2845358..2845458 /Source="Nicolas_upshift_promotors" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2845418 /Source="Nicolas_upshifts" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2845538) /Source="Nicolas_upshifts" /id="D1689" /incds=0 /nref=21 /ntot=141 /MaxReadThrough="7.96763" /MaxDrop="4.994" /score="3.53212058" /energy="-13.8" /TU="U2557" /idTUdmin="U2558" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS complement(2845548..2846534) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12618455, 15556630, 16153181, 18083814, 21347729, 21398478, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructosamine-6-P deglycase" /protein_id="NP_391141.1" /db_xref="EnsemblGenomes-Gn:BSU32610" /db_xref="EnsemblGenomes-Tr:CAB15251" /db_xref="GOA:O32157" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR024713" /db_xref="InterPro:IPR035488" /db_xref="InterPro:IPR035490" /db_xref="PDB:3EUA" /db_xref="SubtiList:BG14002" /db_xref="UniProtKB/Swiss-Prot:O32157" /translation="MSQATAKVNREVQAFLQDLKGKTIDHVFFVACGGSSAIMYPSKY VFDRESKSINSDLYSANEFIQRNPVQLGEKSLVILCSHSGNTPETVKAAAFARGKGAL TIAMTFKPESPLAQEAQYVAQYDWGDEALAINTNYGVLYQIVFGTLQVLENNTKFEQA IEGLDQLQAVYEKALKQEADNAKQFAKAHEKESIIYTMASGANYGVAYSYSICILMEM QWIHSHAIHAGEYFHGPFEIIDESVPFIILLGLDETRPLEERALTFSKKYGKKLTVLD AASYDFTAIDDSVKGYLAPLVLNRVLRSYADELAEERNHPLSHRRYMWKVEY*" /label="frlB CDS" gene complement(2845548..2846534) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /label="frlB gene" upshifts 2846481 /Source="Nicolas_upshifts" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2846484..2846488 /Source="Nicolas_upshift_promotors" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2846577..2846596) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2846590) /Source="Nicolas_upshifts" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2846611..2846618) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2846748) /Source="Nicolas_upshifts" /id="D1690" /incds=0 /nref=116 /ntot=274 /MaxReadThrough="0.87627" /MaxDrop="5.35981" /score="3.53212058" /energy="-13.8" /TU="NA" /idTUdmin="U2558" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2846750..2847124) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excinuclease" /protein_id="NP_391142.1" /db_xref="EnsemblGenomes-Gn:BSU32620" /db_xref="EnsemblGenomes-Tr:CAB15252" /db_xref="GOA:O32158" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR014527" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG14003" /db_xref="UniProtKB/Swiss-Prot:O32158" /translation="MIKIDIPAPNVTITERQQSANDNEPKIKPIHGFIDFHQIPRDKG GIFMFYNIHDELLFVGKARKLRQRIKKHFEDTVSPIKHHRDEVYKIEVCVVDDPMERE IYETYIINTQHSKYNIDKVFFK*" /label="yurQ CDS" gene complement(2846750..2847124) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /label="yurQ gene" upshifts complement(2847188) /Source="Nicolas_upshifts" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2847195..2847206) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2847220..2847226) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2847227..2848345) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 13914427, 16245349, 22271930, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acid oxidase" /protein_id="NP_391143.1" /db_xref="EnsemblGenomes-Gn:BSU32630" /db_xref="EnsemblGenomes-Tr:CAB15253" /db_xref="GOA:O32159" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14004" /db_xref="UniProtKB/Swiss-Prot:O32159" /translation="MKSYIIVGAGILGASTAYHLAKTGARVTVIDRKEPGQATDAAAG IVCPWLSQRRNQDWYQLAKGGARYYKDLIHQLEKDGESDTGYKRVGAISIHTDASKLD KMEERAYKRREDAPEIGDITRLSASETKKLFPILADGYESVHISGAARVNGRALCRSL LSAAEKRGATVIKGNASLLFENGTVTGVQTDTKQFAADAVIVTAGAWANEILKPLGIH FQVSFQKAQIMHFEMTDADTGSWPVVMPPSDQYILSFDNGRIVAGATHENDAGLDDLR VTAGGQHEVLSKALAVAPGLADAAAVETRVGFRPFTPGFLPVVGAVPNVQGLYAANGL GASGLTMGPFLGAELAKLVLGKQTELDLSPYDPAGALA*" /label="dadA CDS" gene complement(2847227..2848345) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /label="dadA gene" promotor_-10 complement(2848370..2848389) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2848376) /Source="Nicolas_upshifts" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2848378..2848988) /Source="Nicolas_S_feature" /locus_tag="new_3353940_3354550_c" /HighExp="G135, H2O2, G180, Paraq, G150, Oxctl, LBGexp, Salt, dia15, Diami" /AntisenseName="yurS" /AntisenseCor="-0.14245591415946501" /AntisenseRegPval="-1.7" /CDS_PredictionProba="0.95340499999999995" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1255" promotor_-35 complement(2848403..2848409) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2848442..2848451 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2848465..2848484 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2848469 /Source="Nicolas_upshifts" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2848482..2848497) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2848486) /Source="Nicolas_upshifts" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2848504..2848508) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2848504..2848650 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type f : factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054592.1" /db_xref="EnsemblGenomes-Gn:BSU32640" /db_xref="EnsemblGenomes-Tr:CAE01466" /db_xref="GOA:Q7WY59" /db_xref="SubtiList:BG14173" /db_xref="UniProtKB/Swiss-Prot:Q7WY59" /translation="MSENRHENEENRRDAAVAKVQNSGNAKVVVSVNTDQDQAQAQSQ DGED*" /label="sspG CDS" gene 2848504..2848650 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /label="sspG gene" CDS 2848650..2848925 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9852018" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391144.1" /db_xref="EnsemblGenomes-Gn:BSU32650" /db_xref="EnsemblGenomes-Tr:CAB15254" /db_xref="SubtiList:BG14005" /db_xref="UniProtKB/Swiss-Prot:O32160" /translation="MNENIIPLNRHTQEIPTTESVIKNSGNSEVHIDIHIDTMPIAFA ILCSALAAKQMTKEEFDMAYTQLREMNRENNSRSSVKQIINQETEEE*" /label="yurS CDS" gene 2848650..2848925 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /label="yurS gene" upshifts complement(2848794) /Source="Nicolas_upshifts" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2848810..2848824) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2848833..2848837) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2848905 /Source="Nicolas_upshifts" /id="D1691" /incds=0 /nref=36 /ntot=86 /MaxReadThrough="1.84089" /MaxDrop="7.4989" /score="15.0184762" /energy="-11" /TU="NA" /idTUdmin="U2560" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(2848989..2849372) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10882093, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10882093, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxalase; lactoylbacillithiol lyase" /protein_id="NP_391145.1" /db_xref="EnsemblGenomes-Gn:BSU32660" /db_xref="EnsemblGenomes-Tr:CAB15255" /db_xref="GOA:O32161" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG14006" /db_xref="UniProtKB/Swiss-Prot:O32161" /translation="MKIVVTSIFVQDQDMALEFYTEKLGFIKKEDVPMGKFRWITLVS PDDQDGTELLLEPNEHPAAKEYQKKIFSEGLPATMFGVADIQKEYNRLKEKGVTFTTE PTKMGEVTIAVFDDTCGNLIQIVQK*" /label="glxB CDS" gene complement(2848989..2849372) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /label="glxB gene" S_feature complement(2849373..2849482) /Source="Nicolas_S_feature" /locus_tag="new_3354935_3355044_c" /HighExp="Salt, G180, H2O2, Paraq, G135, G150, LBGexp, LBGstat, dia15, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1256" CDS complement(2849483..2849761) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097781.1" /db_xref="EnsemblGenomes-Gn:BSU32669" /db_xref="EnsemblGenomes-Tr:CAX52687" /db_xref="GOA:C0H3Q8" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Q8" /translation="MNGNKDAIFKALGDSTRRLILDELSERNELTLYELTIRLITKYD LSITRQAIAKHLSVLEDAGLVTSKRKGKYRVLIFNNEPLKNLLKGWIE*" /label="yuzN CDS" gene complement(2849483..2849761) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /label="yuzN gene" promotor_-10 complement(2849759..2849778) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2849783) /Source="Nicolas_upshifts" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2849793..2849800) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2849924..2850030) /Source="Nicolas_S_feature" /locus_tag="new_3355486_3355592_c" /HighExp="Sw, BI, LPhT, C90, BC, M0t45, Gly, Cold, H2O2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.994" /TUlongSig="SigGF" /TUlongPSig="0.999" /label="S1257" downshifts complement(2849967) /Source="Nicolas_upshifts" /id="D1692" /incds=0 /nref=189 /ntot=303 /MaxReadThrough="3.22318" /MaxDrop="7.82118" /score="0.760415296" /energy="-10.1" /TU="U2564" /idTUdmin="U2565" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2850031..2851428) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16109955, 16431905, 16621837, 20097860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16109955, 16431905, 16621837, 20097860; Product type f: factor" /codon_start=1 /transl_table=11 /product="FeS cluster formation scaffold protein" /protein_id="NP_391146.1" /db_xref="EnsemblGenomes-Gn:BSU32670" /db_xref="EnsemblGenomes-Tr:CAB15256" /db_xref="GOA:O32162" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR010231" /db_xref="SubtiList:BG14007" /db_xref="UniProtKB/Swiss-Prot:O32162" /translation="MAKKMPDIGEYKYGFHDKDVSIFRSERGLTKEIVEEISRMKEEP QWMLDFRLKSLEHFYNMPMPQWGGDLNSLNFDEITYYVKPSERSERSWDEVPEEIKQT FDKLGIPEAEQKYLAGVSAQYESEVVYHNMKEDLEAQGIVFKDTDSALKENEDIFREH WAKVIPPTDNKFAALNSAVWSGGSFIYVPKGVKVETPLQAYFRINSENMGQFERTLII VDEEASVHYVEGCTAPVYTTNSLHSAVVEIIVKKGGYCRYTTIQNWANNVYNLVTKRT VCEENATMEWIDGNIGSKLTMKYPACILKGEGARGMTLSIALAGKGQHQDAGAKMIHL APNTSSTIVSKSISKQGGKVTYRGIVHFGRKAEGARSNIECDTLIMDNKSTSDTIPYN EILNDNISLEHEAKVSKVSEEQLFYLMSRGISEEEATEMIVMGFIEPFTKELPMEYAV EMNRLIKFEMEGSIG*" /label="sufB CDS" gene complement(2850031..2851428) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /label="sufB gene" downshifts 2851226 /Source="Nicolas_upshifts" /id="D1693" /incds=1 /nref=1 /ntot=150 /MaxReadThrough="2.66718" /MaxDrop="3.75483" /score="-4.89805724" /energy="-5" /TU="NA" /idTUdmin="U2560" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS complement(2851449..2851892) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16877383, 20097860, 21236255, 24321018, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16877383, 20097860, 21236255, 24321018, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="iron-sulfur cluster assembly sulfur-transfer protein (Zn(2+)-dependent)" /protein_id="NP_391147.1" /db_xref="EnsemblGenomes-Gn:BSU32680" /db_xref="EnsemblGenomes-Tr:CAB15257" /db_xref="GOA:O32163" /db_xref="InterPro:IPR002871" /db_xref="PDB:1XJS" /db_xref="PDB:2AZH" /db_xref="SubtiList:BG14008" /db_xref="UniProtKB/Swiss-Prot:O32163" /translation="MSFNANLDTLYRQVIMDHYKNPRNKGVLNDSIVVDMNNPTCGDR IRLTMKLDGDIVEDAKFEGEGCSISMASASMMTQAIKGKDIETALSMSKIFSDMMQGK EYDDSIDLGDIEALQGVSKFPARIKCATLSWKALEKGVAKEEGGN*" /label="sufU CDS" gene complement(2851449..2851892) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /label="sufU gene" CDS complement(2851882..2853102) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_391148.1" /db_xref="EnsemblGenomes-Gn:BSU32690" /db_xref="EnsemblGenomes-Tr:CAB15258" /db_xref="GOA:O32164" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR010970" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="PDB:5J8Q" /db_xref="SubtiList:BG14009" /db_xref="UniProtKB/Swiss-Prot:O32164" /translation="MNITDIREQFPILHQQVNGHDLVYLDSAATSQKPRAVIETLDKY YNQYNSNVHRGVHTLGTRATDGYEGAREKVRKFINAKSMAEIIFTKGTTTSLNMVALS YARANLKPGDEVVITYMEHHANIIPWQQAVKATGATLKYIPLQEDGTISLEDVRETVT SNTKIVAVSHVSNVLGTVNPIKEMAKIAHDNGAVIVVDGAQSTPHMKIDVQDLDCDFF ALSSHKMCGPTGVGVLYGKKALLENMEPAEFGGEMIDFVGLYESTWKELPWKFEAGTP IIAGAIGLGAAIDFLEEIGLDEISRHEHKLAAYALERFRQLDGVTVYGPEERAGLVTF NLDDVHPHDVATVLDAEGIAVRAGHHCAQPLMKWLDVTATARASFYLYNTEEEIDKLV EALQKTKEYFTNVF*" /label="sufS CDS" gene complement(2851882..2853102) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /label="sufS gene" CDS complement(2853102..2854415) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16109955, 16431905, 16621837, 19187533, 20097860, 28839209; Product type f: factor" /codon_start=1 /transl_table=11 /product="Fe-S cluster assembly protein SufD" /protein_id="NP_391149.1" /db_xref="EnsemblGenomes-Gn:BSU32700" /db_xref="EnsemblGenomes-Tr:CAB15259" /db_xref="GOA:O32165" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR011542" /db_xref="SubtiList:BG14010" /db_xref="UniProtKB/Swiss-Prot:O32165" /translation="MTLGTKLSVDQEYLKSFSEKHQEPAWLKNLRLQALEQAEDLPMP KPDKTKITNWNFTNFAKHTVDNEPLSSLEDLTDEVKALIDIENEDKTLYVQRDQTPAH LSLSQELKDKGVIFTDILTAAREHSDLVEKYFMKDGVKVDEHKLTALHAALVNGGAFL YVPKNVQVETPVQAVYVHESNDTALFNHVLIVAEDHSSVTYVENYISTVNPKDAVFNI ISEVITGDNASVTYGAVDNLSSGVTTYVNRRGAARGRDSKIEWALGLMNDGDTISENT TNLYGDGTYGDTKTVVVGRGEQTENFTTQIIHFGKASEGYILKHGVMKDSASSIFNGI GKIEHGASKANAEQESRVLMLSEKARGDANPILLIDEDDVTAGHAASVGRVDPIQLYY LMSRGIPKEEAERLVIYGFLAPVVNELPIEGVKKQLVSVIERKVK*" /label="sufD CDS" gene complement(2853102..2854415) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /label="sufD gene" CDS complement(2854433..2855218) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16431905, 20097860, 28839209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16431905, 20097860, 28839209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur mobilizing ABC protein, ATPase" /protein_id="NP_391150.1" /db_xref="EnsemblGenomes-Gn:BSU32710" /db_xref="EnsemblGenomes-Tr:CAB15260" /db_xref="GOA:P80866" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010230" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14011" /db_xref="UniProtKB/Swiss-Prot:P80866" /translation="MAASTLTIKDLHVEIEGKEILKGVNLEIKGGEFHAVMGPNGTGK STLSAAIMGHPKYEVTKGSITLDGKDVLEMEVDERAQAGLFLAMQYPSEISGVTNADF LRSAINARREEGDEISLMKFIRKMDENMEFLEMDPEMAQRYLNEGFSGGEKKRNEILQ LMMIEPKIAILDEIDSGLDIDALKVVSKGINKMRSENFGCLMITHYQRLLNYITPDVV HVMMQGRVVKSGGAELAQRLEAEGYDWIKQELGIEDETVGQEA*" /label="sufC CDS" gene complement(2854433..2855218) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /label="sufC gene" promotor_-10 complement(2855262..2855281) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(2855263) /Source="Nicolas_upshifts" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" promotor_-35 complement(2855295..2855302) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" promotor_-10 complement(2855319..2855338) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(2855328) /Source="Nicolas_upshifts" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" S_feature complement(2855330..2855411) /Source="Nicolas_S_feature" /locus_tag="new_3360892_3360973_c" /HighExp="Salt, HiOs, B60, LoTm, T1.0H, Gly, T2.0H, C30, Etha, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1258" promotor_-35 complement(2855354..2855358) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" misc_RNA complement(2855375..2855622) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /product="small regulatory RNA or messenger RNA" /experiment="publication(s) with functional evidences, PMID:18948176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176; Product type n: RNA" /label="bsrI RNA" gene complement(2855375..2855622) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /label="bsrI gene" CDS complement(2855412..2855549) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin antitoxin system" /protein_id="YP_003097782.1" /db_xref="EnsemblGenomes-Gn:BSU32719" /db_xref="EnsemblGenomes-Tr:CAX52688" /db_xref="UniProtKB/Swiss-Prot:C0H3Q9" /translation="MEKAMQLSHGIGYEEYGRRLETRMKVERQRELDYEKSKRISAGA Y*" /label="yuzK CDS" gene complement(2855412..2855549) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /label="yuzK gene" S_feature complement(2855550..2855634) /Source="Nicolas_S_feature" /locus_tag="new_3361112_3361196_c" /HighExp="HiOs, Salt, B60, S5, T1.0H, S8, HiTm, S7, T1.30H, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63415999999999995" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1259" promotor_-10 complement(2855618..2855637) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2855634) /Source="Nicolas_upshifts" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2855636..2855742) /Source="Nicolas_S_feature" /locus_tag="new_3361198_3361304_c" /HighExp="S8, S5, S7, S6, S4, BT, ferm, nit, S3, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1260" promotor_-35 complement(2855653..2855656) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2855743..2856120) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391151.1" /db_xref="EnsemblGenomes-Gn:BSU32720" /db_xref="EnsemblGenomes-Tr:CAB15261" /db_xref="GOA:O32166" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG14012" /db_xref="UniProtKB/Swiss-Prot:O32166" /translation="MEGFSLNQDRGSMQDALKQYKHGLGTFEQKMPLMGRKFNEFTEQ CFAGNSLTEREKQLIALGIAINAQDEYCMIYHTKGCLDQGASEENILEAVSVAAAFGG GAAFSQGVTVVQQCIEEFGNTTH*" /label="yurZ CDS" gene complement(2855743..2856120) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /label="yurZ gene" promotor_-10 complement(2856137..2856148) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-10" upshifts complement(2856143) /Source="Nicolas_upshifts" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="upshifts" promotor_-35 complement(2856162..2856168) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-35" CDS complement(2856205..2857029) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 16109943, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 16109943, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, substrate binding lipoprotein" /protein_id="NP_391152.1" /db_xref="EnsemblGenomes-Gn:BSU32730" /db_xref="EnsemblGenomes-Tr:CAB15262" /db_xref="GOA:O32167" /db_xref="InterPro:IPR004872" /db_xref="PDB:4GOT" /db_xref="SubtiList:BG14013" /db_xref="UniProtKB/Swiss-Prot:O32167" /translation="MKKLFLGALLLVFAGVMAACGSNNGAESGKKEIVVAATKTPHAE ILKEAEPLLKEKGYTLKVKVLSDYKMYNKALADKEVDANYFQHIPYLEQEMKENTDYK LVNAGAVHLEPFGIYSKTYKSLKDLPDGATIILTNNVAEQGRMLAMLENAGLITLDSK VETVDATLKDIKKNPKNLEFKKVAPELTAKAYENKEGDAVFINVNYAIQNKLNPKKDA IEVESTKNNPYANIIAVRKGEEDSAKIKALMEVLHSKKIKDFIEKKYDGAVLPVSE*" /label="metQ CDS" gene complement(2856205..2857029) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /label="metQ gene" downshifts complement(2856213) /Source="Nicolas_upshifts" /id="D1694" /incds=0 /nref=167 /ntot=246 /MaxReadThrough="2.13581" /MaxDrop="6.33517" /score="28.8468637" /energy="-12.6" /TU="NA" /idTUdmin="U2569" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(2856362) /Source="Nicolas_upshifts" /id="D1695" /incds=1 /nref=2 /ntot=171 /MaxReadThrough="6.93658" /MaxDrop="2.3341" /score="28.8468637" /energy="-12.6" /TU="U2569" /idTUdmin="U2569" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-35 2856389..2856394 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2856410..2856428 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2856412 /Source="Nicolas_upshifts" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2857043..2857711) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 15849754, 16850406, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 15849754, 16850406, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, permease component" /protein_id="NP_391153.1" /db_xref="EnsemblGenomes-Gn:BSU32740" /db_xref="EnsemblGenomes-Tr:CAB15263" /db_xref="GOA:O32168" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14014" /db_xref="UniProtKB/Swiss-Prot:O32168" /translation="MFEKYFPNVDLTELWNATYETLYMTLISLLFAFVIGVILGLLLF LTSKGSLWQNKAVNSVIAAVVNIFRSIPFLILIILLLGFTKFLVGTILGPNAALPALV IGSAPFYARLVEIALREVDKGVIEAAKSMGAKTSTIIFKVLIPESMPALISGITVTAI ALIGSTAIAGAIGSGGLGNLAYVEGYQSNNADVTFVATVFILIIVFIIQIIGDLITNI IDKR*" /label="metP CDS" gene complement(2857043..2857711) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /label="metP gene" CDS complement(2857704..2858729) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 17038623; Product type t: transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter (ATP-binding protein)" /protein_id="NP_391154.1" /db_xref="EnsemblGenomes-Gn:BSU32750" /db_xref="EnsemblGenomes-Tr:CAB15264" /db_xref="GOA:O32169" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017908" /db_xref="InterPro:IPR018449" /db_xref="InterPro:IPR026253" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14015" /db_xref="UniProtKB/Swiss-Prot:O32169" /translation="MINLQDVSKVYKSKHGDVNAVQNVSLSIKKGEIFGIIGYSGAGK SSLIRLLNGLEKPTSGTVEVAGTKINEVNGRGLRKARHEISMIFQHFNLLWSRTVRDN IMFPLEIAGVKKSERIKRANELIKLVGLEGKEKSYPSQLSGGQKQRVGIARALANNPK VLLCDEATSALDPQTTDSILDLLSDINERLGLTIVLITHEMHVIRKICNRVAVMENGK VVEEGEVLDVFKNPKEQMTKRFVQQVTEPEETKETLQHLLDDTASGKMVQLTFVGESA EQPLITEMIRNFNVSVNILQGKISQTKDGAYGSLFIHIDGDEEEVQNVIRFINDKQVK AEVITNV*" /label="metN CDS" gene complement(2857704..2858729) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /label="metN gene" S_feature complement(2858730..2858834) /Source="Nicolas_S_feature" /locus_tag="new_3364292_3364396_c" /HighExp="MG 5, MG t5, MG 10, BMM, MG-0.2, GM 25, MG-0.1, MG 15, M9-exp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1261" misc_RNA complement(2858835..2858941) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswH RNA" gene complement(2858835..2858941) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /label="mswH gene" downshifts 2858904 /Source="Nicolas_upshifts" /id="D1696" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="1.54417" /MaxDrop="5.51028" /score="-1.70178746" /energy="-11.2" /TU="NA" /idTUdmin="U2568" /TUdmin=2420 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2858968..2858987) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2858980) /Source="Nicolas_upshifts" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2858982..2859055) /Source="Nicolas_S_feature" /locus_tag="new_3364544_3364617_c" /HighExp="M9-stat, S2, LoTm, T5.0H, HiOs, B60, S3, T3.30H, LPhT, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1262" promotor_-35 complement(2859003..2859010) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2859056..2859400) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391155.1" /db_xref="EnsemblGenomes-Gn:BSU32760" /db_xref="EnsemblGenomes-Tr:CAB15265" /db_xref="InterPro:IPR003033" /db_xref="InterPro:IPR036527" /db_xref="SubtiList:BG14016" /db_xref="UniProtKB/Swiss-Prot:O32170" /translation="MEKAEVLEDEYQHLFLKPLLNASTLLITFQGEAEALTVSINEQG EMKKVSPPQTSNLTFYGNQTEIIDLLHGDISLQHLIQSGSLKVKGSFRALLKLEAILW LTNGFFQRILKN*" /label="yusD CDS" gene complement(2859056..2859400) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /label="yusD gene" S_feature complement(2859401..2859506) /Source="Nicolas_S_feature" /locus_tag="new_3364963_3365068_c" /HighExp="LPhT, HiOs, M9-stat, dia5, T2.0H, Diami, T1.30H, T0.30H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA, SigA" /TUshortPSig="1, 0.996, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S1263" CDS complement(2859507..2859827) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_391156.1" /db_xref="EnsemblGenomes-Gn:BSU32770" /db_xref="EnsemblGenomes-Tr:CAB15266" /db_xref="GOA:O32171" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14017" /db_xref="UniProtKB/Swiss-Prot:O32171" /translation="MKELQEHELDHIEDDVYLLYLYTPFCGTCQLASKMLTVVKEMLP DVAFYQNNVNYSPTFAKAYQIESVPCFLLFKGGKMVERGYAFHSVSYLYELIKQKSSS ASHL*" /label="yusE CDS" gene complement(2859507..2859827) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /label="yusE gene" CDS complement(2859829..2860269) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12794188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease" /protein_id="NP_391157.1" /db_xref="EnsemblGenomes-Gn:BSU32780" /db_xref="EnsemblGenomes-Tr:CAB15267" /db_xref="GOA:O32172" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG14018" /db_xref="UniProtKB/Swiss-Prot:O32172" /translation="MLAVNFTAFFYNLNISNLTRQVNKMKMDELEKVMIVEGKSDKEK IESVLNEPMRIICTNGTISQLRLEELADELYDKDVYILVDADESGEKLRKQLKREFNE ACHLHVDRAYKEVAAAPRHHIASVLLRANLNVHTIFLERKSRGV*" /label="yusF CDS" gene complement(2859829..2860269) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /label="yusF gene" CDS complement(2860269..2860505) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391158.1" /db_xref="EnsemblGenomes-Gn:BSU32790" /db_xref="EnsemblGenomes-Tr:CAB15268" /db_xref="InterPro:IPR020140" /db_xref="SubtiList:BG14019" /db_xref="UniProtKB/Swiss-Prot:O32173" /translation="MAFDKQKLDVTNDVTGRFQNGRLSLYHDNEMIGQMTSMNEYELK SGYSFENEKFYKTADVVSGDDAKYVDCDYENGWC*" /label="yusG CDS" gene complement(2860269..2860505) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /label="yusG gene" downshifts complement(2860281) /Source="Nicolas_upshifts" /id="D1697" /incds=0 /nref=35 /ntot=245 /MaxReadThrough="6.00162" /MaxDrop="3.9147" /score="-1.53913693" /energy="-11" /TU="U2570,U2571,U2572" /idTUdmin="U2574" /TUdmin=723 /isTUend="FALSE" /label="downshifts" upshifts complement(2860520) /Source="Nicolas_upshifts" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2860525..2860536) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2860551..2860557) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2860561..2860944) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 20882995, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine cleavage system protein H (lipoyl acceptor protein)" /protein_id="NP_391159.1" /db_xref="EnsemblGenomes-Gn:BSU32800" /db_xref="EnsemblGenomes-Tr:CAB15269" /db_xref="GOA:O32174" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR002930" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR017453" /db_xref="InterPro:IPR033753" /db_xref="SubtiList:BG14020" /db_xref="UniProtKB/Swiss-Prot:O32174" /translation="MSIPKDLRYSGEHEWVKVEGEKARIGITHFAQSELGDIVFVELP EVGAEIKADEPFGSVESVKTVSELYAPINGTVVEVNEDLDDSPEFVNESPYEKAWMIV VEPSDASEIEKLMTAEQYEEMTQED*" /label="gcvH CDS" gene complement(2860561..2860944) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /label="gcvH gene" promotor_-10 complement(2860971..2860990) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-10" upshifts complement(2860982) /Source="Nicolas_upshifts" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="upshifts" promotor_-35 complement(2861003..2861010) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-35" CDS complement(2861011..2861367) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /EC_number="1.20.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with thioredoxin domain and regulator domain" /protein_id="NP_391160.1" /db_xref="EnsemblGenomes-Gn:BSU32810" /db_xref="EnsemblGenomes-Tr:CAB15270" /db_xref="GOA:O32175" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14021" /db_xref="UniProtKB/Swiss-Prot:O32175" /translation="MSLTFYWYPKCGTCRKAKKWLEEHGKEINEIHIAEQPPSKEELK ALYEKSGLDLKKFFNTSGMKYRELNLKEKLYHMSEDEQLELLASDGMLIKRPLTTDGE KVTVGFKEDQFEENWA*" /label="yusI CDS" gene complement(2861011..2861367) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /label="yusI gene" promotor_-10 complement(2861390..2861409) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-10" upshifts complement(2861400) /Source="Nicolas_upshifts" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="upshifts" promotor_-35 complement(2861423..2861428) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-35" CDS complement(2861478..2863262) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase (FAD dependent)" /protein_id="NP_391161.1" /db_xref="EnsemblGenomes-Gn:BSU32820" /db_xref="EnsemblGenomes-Tr:CAB15271" /db_xref="GOA:O32176" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG14022" /db_xref="UniProtKB/Swiss-Prot:O32176" /translation="MAKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDY IEQDVLPHIDDIENHQFEHSVRLLKKAGELGLLGADVPEEYGGLGLDKISSALITEKF SRAGSFSLSYGAHVGIGSLPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDAL GAKTTAVLNEAGTHYVLTGEKQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVST GPEEKKMGIKGSSTRTLILDQAEVPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGA SKRVIELSAAYANQRRQFKTPIAGFSLTQEKIGTMASRLYAMESSVYRTVGLFEDNMS QFTAEDLKDGRQIAKSIAEYAIECSLNKVFGSETLDYIVDEGVQIHGGYGFMQEYEVE RAYRDSRINRIFEGTNEINRLIVPSTFLKKALKGELPLFEKAQSLQEELMMLMPEEPG SGVLEQEKYIVKQAKKIALFAAGLAAQKYGKAIDREQEILVNVADIVSNVYAMESAVL RTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEIEAHAKESLIAMEEGDSLRMMLSALRK LTRVTPKNVIQKKREAAAGIFEAEKYTV*" /label="fadE CDS" gene complement(2861478..2863262) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /label="fadE gene" downshifts complement(2861488) /Source="Nicolas_upshifts" /id="D1698" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="4.78872" /MaxDrop="6.88218" /score="31.8022607" /energy="-16.4" /TU="U2574" /idTUdmin="U2576" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2863277..2864452) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /EC_number="2.3.1.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acyltransferase" /protein_id="NP_391162.1" /db_xref="EnsemblGenomes-Gn:BSU32830" /db_xref="EnsemblGenomes-Tr:CAB15272" /db_xref="GOA:O32177" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG14023" /db_xref="UniProtKB/Swiss-Prot:O32177" /translation="MKEAVIVSGARTPVGKAKKGSLATVRPDDLGAICVKETLKRAGG YEGNIDDLIIGCATPEAEQGLNMARNIGALAGLPYTVPAITVNRYCSSGLQSIAYAAE KIMLGAYDTAIAGGAESMSQVPMMGHVTRPNLALAEKAPEYYMSMGHTAEQVAKKYGV SREDQDAFAVRSHQNAAKALAEGKFKDEIVPVEVTVTEIGEDHKPMEKQFVFSQDEGV RPQTTADILSTLRPAFSVDGTVTAGNSSQTSDGAAAVMLMDREKADALGLAPLVKFRS FAVGGVPPEVMGIGPVEAIPRALKLAGLQLQDIGLFELNEAFASQAIQVIRELGIDEE KVNVNGGAIALGHPLGCTGTKLTLSLIHEMKRRNEQFGVVTMCIGGGMGAAGVFELC* " /label="fadA CDS" gene complement(2863277..2864452) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /label="fadA gene" CDS complement(2864463..2866832) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /EC_number="1.1.1.35" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17189250, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase" /protein_id="NP_391163.2" /db_xref="EnsemblGenomes-Gn:BSU32840" /db_xref="EnsemblGenomes-Tr:CAB15273" /db_xref="GOA:O32178" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14024" /db_xref="UniProtKB/Swiss-Prot:O32178" /translation="MHKHIRKAAVLGSGVMGSGIAAHLANIGIPVLLLDIVPNDLTKE EEKKGLTKDSSEVRSRLSRQAMKKLLKQKPAPLTSAKNTSYITPGNLEDDAEKLKEAD WIIEVVVENLEVKKKIFALVDEHRKTGSIVSSNTSGISVQEMAEGRSDDFKAHFLGTH FFNPARYLKLLEIIPIKETDPDILKFMTAFGENVLGKGVVTAKDTPNFIANRIGTYGL LVTVQEMLKGGYQVGEVDSITGPLIGRPKSATFRTLDVVGLDTFAHVARNVYDKADGD EKEVFRIPSFMNDMLEKGWIGSKAGQGFYKKEGKTIYELDPVTLTYGERTKMKSPALE AAKQAKGTKAKMKALIYSDDRAGRLLWNITSQTLLYSAELLGEIADDIHAIDQAMKWG FGWELGPFEMWDAIGLKQSAEKLEQLGADMPGWIKEMLDKGNETFYIKENGTVFYYDR GEYRAVKENKKRIHLQALKETKGVIAKNSGASLIDLGDDVALLEFHSKSNAIGLDIIQ MIHKGLEETERNYKGLVIGNQGKNFCVGANLAMILMEVQDDNFLEVDFVIRRFQETMM KIKYSAKPVVAAPFGMTLGGGTEACLPAARIQAASEAYMGLVESGVGLIPGGGGNKEL YINHLRRGHDPMNAAMKTFETIAMAKVSASAQEAREMNILKETDQISVNQDHLLYDAK QLAASLYDTGWRPPVKEKVKVPGETGYAALLLGAEQMKLSGYISEHDFKIAKKLAYVI AGGKVPFGTEVDEEYLLEIEREAFLSLSGEAKSQARMQHMLVKGKPLRN*" /label="fadN CDS" gene complement(2864463..2866832) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /label="fadN gene" promotor_-35 2866251..2866256 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2866271..2866289 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2866274 /Source="Nicolas_upshifts" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2866900..2866919) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-10" upshifts complement(2866903) /Source="Nicolas_upshifts" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="upshifts" S_feature complement(2866911..2867177) /Source="Nicolas_S_feature" /locus_tag="new_3372473_3372739_c" /HighExp="S8, S6, S7, BT, B36, G/S, B60, S5, Pyr, S3" /AntisenseName="yuzL" /AntisenseCor="0.77564732124057401" /AntisenseRegPval="-54.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1264" promotor_-35 complement(2866933..2866940) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-35" promotor_-35 2866958..2866964 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2866979..2866990 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2867001 /Source="Nicolas_upshifts" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="upshifts" CDS 2867007..2867153 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17189250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097783.1" /db_xref="EnsemblGenomes-Gn:BSU32849" /db_xref="EnsemblGenomes-Tr:CAX52689" /db_xref="InterPro:IPR025625" /db_xref="UniProtKB/Swiss-Prot:C0H3R0" /translation="MVREKKNPSSAAVSAASVKGDAGPTQHYGGGKRTSQNQQYKKHN MGQS*" /label="yuzL CDS" gene 2867007..2867153 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /label="yuzL gene" S_feature 2867154..2868180 /Source="Nicolas_S_feature" /locus_tag="new_3372716_3373742" /HighExp="S8, S5, S7, S4, S6, nit, ferm, T5.0H, S3, LoTm" /AntisenseName="fadM" /AntisenseCor="0.80952501049450498" /AntisenseRegPval="-63" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1265" CDS complement(2867178..2868086) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /EC_number="1.5.5.2" /function="3.2: Degradation" /experiment="publication(s) with functional evidences, PMID:17189250, 17536821, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 17536821, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline dehydrogenase 1" /protein_id="NP_391164.1" /db_xref="EnsemblGenomes-Gn:BSU32850" /db_xref="EnsemblGenomes-Tr:CAB15274" /db_xref="GOA:O32179" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG14025" /db_xref="UniProtKB/Swiss-Prot:O32179" /translation="MLRHVFLFLSQNKTLTKFAKAYGTRLGARRFVAGDTIESAVKTV KRLNRSGLCATIDYLGEYAASEKEANQVAEECKKAIQAIAEHQLNSELSLKLTSIGLD LSEELALTHLRAILSVAKQYDVAVTIDMEDYSHYEQTLSIYRQCKQEFEKLGTVIQAY LYRAAEDIRKMRDLKPNLRLVKGAYKESAAVAFPDKRGTDLHFQSLIKLQLLSGNYTA VATHDDDIIAFTKQLVAEHQIPASQFEFQMLYGIRPERQKELAKEGYRMRVYVPYGTD WFSYFMRRIAERPANAAFVLKGILKK*" /label="putM CDS" gene complement(2867178..2868086) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /label="putM gene" S_feature complement(2868087..2868609) /Source="Nicolas_S_feature" /locus_tag="new_3373649_3374171_c" /HighExp="S8, S6, S7, BT, B36, B60, G/S, Pyr, S5, SMMPr" /AntisenseName="yuzM" /AntisenseCor="0.77827902986544495" /AntisenseRegPval="-55.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1266" CDS 2868181..2868426 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097784.1" /db_xref="EnsemblGenomes-Gn:BSU32859" /db_xref="EnsemblGenomes-Tr:CAX52690" /db_xref="InterPro:IPR012347" /db_xref="UniProtKB/Swiss-Prot:C0H3R1" /translation="MDNQQQSQMPPSVISTKDHLYLNDMLNWNLLAMKKAHFMAQQCQ DQTLKQELDRVGHMHHDHYQRILKHLQPGQQQSGYIQ*" /label="yuzM CDS" gene 2868181..2868426 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /label="yuzM gene" CDS 2868439..2868771 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat-like protein" /protein_id="NP_391165.1" /db_xref="EnsemblGenomes-Gn:BSU32860" /db_xref="EnsemblGenomes-Tr:CAB15275" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG14026" /db_xref="UniProtKB/Swiss-Prot:O32180" /translation="MNQQNQKISNPQTPVPTTSEMNDRDFVNELLTTEKYMTTAYCTA LHEFSHESLYQDIQSIFDESQKAQRKLYDLMFQYGWYSVEAEDSQKLQQSYQKFQQTI QQQSPYQQ*" /label="yusN CDS" gene 2868439..2868771 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /label="yusN gene" promotor_-10 complement(2868592..2868611) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2868609) /Source="Nicolas_upshifts" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2868625..2868634) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2868760 /Source="Nicolas_upshifts" /id="D1699" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="2.684" /MaxDrop="5.38418" /score="9.88876972" /energy="-10.2" /TU="NA" /idTUdmin="U2575" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2868832..2868839 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2868853..2868872 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2868864 /Source="Nicolas_upshifts" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="upshifts" CDS 2868930..2869397 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12923086, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923086, 19286808; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, low level antibiotic resistance)" /protein_id="NP_391166.1" /db_xref="EnsemblGenomes-Gn:BSU32870" /db_xref="EnsemblGenomes-Tr:CAB15276" /db_xref="GOA:O32181" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1S3J" /db_xref="SubtiList:BG14027" /db_xref="UniProtKB/Swiss-Prot:O32181" /translation="MKSADQLMSDIQLSLQALFQKIQPEMLESMEKQGVTPAQLFVLA SLKKHGSLKVSEIAERMEVKPSAVTLMADRLEQKNLIARTHNTKDRRVIDLSLTDEGD IKFEEVLAGRKAIMARYLSFLTEEEMLQAAHITAKLAQAAETDEKQNMKRGNG*" /label="mdtR CDS" gene 2868930..2869397 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /label="mdtR gene" CDS 2869394..2871019 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19286808; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_391167.1" /db_xref="EnsemblGenomes-Gn:BSU32880" /db_xref="EnsemblGenomes-Tr:CAB15277" /db_xref="GOA:O32182" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14028" /db_xref="UniProtKB/Swiss-Prot:O32182" /translation="MKMSKEGKQSKRTLLITGLIIAMFFSALDGTIVGTAMPKIVGDL GGLSMMTWLTTAYLLTSTTIVPIAGKLADLLGRRIVYVSGLIIFMAASALCGMANNMT ELIIFRGLQGIGGGIMMPMAMIVIGDLFTGKQRAKFQGVFGAIYGLASVIGPQIGGWI VDSLNWKWVFYINLPVGIIAVIFIARGLQGRQQTGPINFDIAGIFTMIVGVVSLLLAL SFGGKDYAWDSWQILGLFALALIGIVSFIIVESKAKEPILPMYLFKNRTFTFLNLIGF FMSIGMFGAITFVPFFMQGIVGVSASESGTIMTPMMISMIITSIIGGQLVYKIGIKPQ IITGMLVMAGGFLLLTTLDLDTSKLVATSFMAIIGLGMGLVMPILTLALQESFSKEEL GVVTSSSQFFRSIGGTFGITMLGAVMNARSGNLLTDKLVPYLDSLPAQASSFAAQLKG MIDTNPQGLLQSLFSPDAVKQIPAAFSSHIVPILKTSLMDSLHSVFYTGLIFIAVGAV FTLFLKPIKLSNKKAEDQQEKEKAAKAVESPSH*" /label="mdtP CDS" gene 2869394..2871019 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /label="mdtP gene" downshifts 2871004 /Source="Nicolas_upshifts" /id="D1700" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="0.3188" /MaxDrop="5.64223" /score="42.0555168" /energy="-17.7" /TU="NA" /idTUdmin="U2577" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2871055..2871438) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25219626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydratase of unidentified specificity (tautomerase superfamily)" /protein_id="NP_391168.1" /db_xref="EnsemblGenomes-Gn:BSU32890" /db_xref="EnsemblGenomes-Tr:CAB15278" /db_xref="GOA:O32183" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG14029" /db_xref="UniProtKB/Swiss-Prot:O32183" /translation="MPFVQIHLRSGRSEVWLQKLSRTIHQSMIEEINVPEDDYFQVIR QYEKSEFFYDPFYLQVERTDELIYIHFTLKQSRTTEQKKALYRSIASRIHSELGVRKE DVFIMLAGNQDEDWSFGNGRAQMIE*" /label="yusQ CDS" gene complement(2871055..2871438) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /label="yusQ gene" CDS complement(2871457..2871846) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15294834; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_391169.1" /db_xref="EnsemblGenomes-Gn:BSU32900" /db_xref="EnsemblGenomes-Tr:CAB15279" /db_xref="GOA:O32184" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14030" /db_xref="UniProtKB/Swiss-Prot:O32184" /translation="MKGMFFCARAVVPFMKKSKDGAIVNVGSIAGITGAGSSMPYAVS KSAVHGLTKSLAHALAPEIRVSGVAPGAVATRWWAGREEKMKSMIGSLLLQCIAEPDD VAKLICSLIEQESLTGQIITIDSGQTL*" /label="yusR CDS" gene complement(2871457..2871846) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /label="yusR gene" CDS complement(2871868..2872197) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved enzyme of unknown function" /protein_id="NP_391170.1" /db_xref="EnsemblGenomes-Gn:BSU32910" /db_xref="EnsemblGenomes-Tr:CAB15280" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14031" /db_xref="UniProtKB/Swiss-Prot:O32185" /translation="MNVLNKIALVTGGGTGIGKAASMELAKRGAIVAVNYSRSQSEAE ETVEMIQKAGGQAFAIQADVSKNSDVQDMIQAIVNTHGTVDILVNNASITRHIPMDDL EAATEDV*" /label="yusS CDS" gene complement(2871868..2872197) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /label="yusS gene" promotor_-10 complement(2872232..2872251) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2872239..2872246 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2872246) /Source="Nicolas_upshifts" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2872261..2872280 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2872265..2872272) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2872271 /Source="Nicolas_upshifts" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="upshifts" CDS 2872331..2873218 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591, 17526699, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591, 17526699, 27965289; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown specificity(LysR family)" /protein_id="NP_391171.1" /db_xref="EnsemblGenomes-Gn:BSU32920" /db_xref="EnsemblGenomes-Tr:CAB15281" /db_xref="GOA:O32186" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14032" /db_xref="UniProtKB/Swiss-Prot:O32186" /translation="MESGDLRVFQMVAREGTITKAALQLGYVQSNVTARIQQLEAELG TTLFLRHNRGMTLSASGKLLLDYANKIIGLLDEASKALSSSAEPSGPLMIGCTQTTAA VRLPKLLASYYEEHPNVQLSLTTGHTQFLLDKVLRYELDGAFIGCECHHPELESYPAF EEEPVVVSAASVPDVEEAITKPILVYSTGCSYRETLEKWLRSVGVTQPVIMEFGTLEA IIGGVTAGLGISLLPRTVVQKHEAEGSIRLYPLPEALSQMKTEFIVRKDSFISSALRT FMDSFTPVKTAESQKSSLL*" /label="yusT CDS" gene 2872331..2873218 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /label="yusT gene" CDS complement(2873238..2873525) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22078549" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391172.1" /db_xref="EnsemblGenomes-Gn:BSU32930" /db_xref="EnsemblGenomes-Tr:CAB15282" /db_xref="InterPro:IPR020393" /db_xref="SubtiList:BG14033" /db_xref="UniProtKB/Swiss-Prot:O32187" /translation="MRKLLAVFSKGRWKMEQKLQEQLDGLLEKYTELLLGETNDELKE EVKQWILYTHIAKSMPPLAKHWNATYPDAKQGIKEIIQHIKELNEAHRNKQ*" /label="yusU CDS" gene complement(2873238..2873525) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /label="yusU gene" downshifts complement(2873250) /Source="Nicolas_upshifts" /id="D1701" /incds=0 /nref=113 /ntot=280 /MaxReadThrough="1.05563" /MaxDrop="5.97768" /score="17.1690128" /energy="-13.2" /TU="NA" /idTUdmin="U2580" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2873550..2874377) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 24847778, 25288929; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III)-siderophore transporter (ATP binding component)" /protein_id="NP_391173.1" /db_xref="EnsemblGenomes-Gn:BSU32940" /db_xref="EnsemblGenomes-Tr:CAB15283" /db_xref="GOA:O32188" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14034" /db_xref="UniProtKB/Swiss-Prot:O32188" /translation="MGMSAISTETLSLGYGDAVIIDELNLTIPKGEITVFIGSNGCGK STLLRSLARLMKPRGGSVLLEGRAIAKLPTKEVAKELAILPQGPSAPEGLTVHQLVKQ GRYPYQNWLKQWSKEDEEAVERALKATKLEDMADRAVDSLSGGQRQRAWIAMTLAQET DIILLDEPTTYLDMTHQIEILDLLFELNEKEDRTIVMVLHDLNLACRYAHHLVAIKDK RIYAEGRPEEVITCDLVQNVFSMNCQVTQDPLFGTPLCIPHGRGRCIVQEAAFTSHG* " /label="feuV CDS" gene complement(2873550..2874377) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /label="feuV gene" downshifts complement(2873566) /Source="Nicolas_upshifts" /id="D1702" /incds=0 /nref=2 /ntot=77 /MaxReadThrough="5.36684" /MaxDrop="3.19022" /score="11.3999731" /energy="-19.8" /TU="U2580" /idTUdmin="U2581" /TUdmin=220 /isTUend="FALSE" /label="downshifts" S_feature complement(2874378..2874515) /Source="Nicolas_S_feature" /locus_tag="new_3379940_3380077_c" /HighExp="T-5.40H, Paraq, H2O2, GM-0.2, HiOs, GM 5, dia15, GM 25, T-3.40H, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1267" promotor_-10 complement(2874500..2874519) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2874515) /Source="Nicolas_upshifts" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2874535..2874538) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2874595..2875032) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26497467; Product type m : membrane component" /codon_start=1 /transl_table=11 /product="spore lipoprotein" /protein_id="NP_391174.1" /db_xref="EnsemblGenomes-Gn:BSU32950" /db_xref="EnsemblGenomes-Tr:CAB15284" /db_xref="InterPro:IPR025623" /db_xref="SubtiList:BG14035" /db_xref="UniProtKB/Swiss-Prot:O32189" /translation="MHLIRAAGAVCLAVVLIAGCRFNEDQHQAEGENTAVTQLKSVPY SNFSLRVSYGDGEHNRYEGIYTKNGTQEKAEIQDKLSGVNQEGEEALDEMKMILSELS VTDQMAETEVIHSVLAAFNLDSHYDHIDLKLKLKDGSIREIKK*" /label="cotNW CDS" gene complement(2874595..2875032) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /label="cotNW gene" promotor_-10 complement(2875056..2875074) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-10" upshifts complement(2875062) /Source="Nicolas_upshifts" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="upshifts" promotor_-35 complement(2875090..2875095) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-35" CDS complement(2875142..2876650) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; C-terminal part of YusY" /db_xref="SubtiList:BG14037" /translation="GLMNRLSADFQSSLVTLDHKLVDINQDVWNELLTKPGLRDVSYI LNERRQRVAEKLSPGKEKLIGNLAVDGYHAWSDLYNMVVGKMTIPYEENGENKQLSVG QAENMMDHQDRTVRKTVYERFRQAWESKQDIFSSTLNHLAGFRLETYKARGWENVLKE PLQINRMKKETLDTMWQVITENKKPFVQFLNRKASMLGLEKLSWYDVEAPIGSDGKVY SYDEAANIITSQFSTFGKKLSSFTEKAFRDGWIEAEDRSGKRVGGFCTSFPDSGESRI FMTFSGSASNVSTLAHELGHAFHQEAMLNVRPLNRSYAMNVAETASTFAEMIVADATV QQAETREEKLVLLEDKVQRSVAFFMNIHARFLFETRFYEERKRGVVPASRLNELMEEA QREAYCNALEEYHPLFWASKLHFHITRVPFYNFPYTFGYLFSLGIYALALEEKDTFEE KYMALLRDTASMTVEDLAMKHLGADITKRDFWENAIKLAVRDAETFLQMTES*" /label="yusYc CDS" gene complement(2875142..2876650) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /pseudo /label="yusYc gene" downshifts complement(2875163) /Source="Nicolas_upshifts" /id="D1703" /incds=0 /nref=125 /ntot=240 /MaxReadThrough="2.57385" /MaxDrop="6.5698" /score="6.83314975" /energy="-12" /TU="NA" /idTUdmin="U2582" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(2876641..2876937) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; N-terminal part of YusY" /translation="MALQGVGQRWDLDSFFKGGSQSEEFKGYIEKLSQSLRAFQDRTD AFQVPESPEEAEGLTALLDLFEQTSVKLQQAGAFVACLQAQNINDQKAIEHQAS*" /label="yusYn CDS" gene complement(2876641..2876937) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /pseudo /label="yusYn gene" promotor_-10 complement(2876960..2876979) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2876976) /Source="Nicolas_upshifts" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2876994..2876997) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2877014..2877019 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2877031..2877050 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2877031 /Source="Nicolas_upshifts" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="upshifts" CDS 2877071..2877913 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative short-chain acyl dehydrogenase" /protein_id="NP_391177.1" /db_xref="EnsemblGenomes-Gn:BSU32980" /db_xref="EnsemblGenomes-Tr:CAB15287" /db_xref="GOA:P37959" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10863" /db_xref="UniProtKB/Swiss-Prot:P37959" /translation="MNKKIAIVTGASSGFGLLAAVKLARSFFVIATSRQPEKAEQLRE LAAAHNVSDSIHITALDVTDEQSIVSFGKAVSAYAPIDLLVNNAGTAYGGFIEDVPME HFRQQFETNVFGVIHVTKTVLPYIRKHGGAKIINVSSISGLTGFPALSPYVSSKHALE GFSESLRIELLPFGIETALIEPGSYKTSIWSTSLSNFMSVPADDSAYHQYYKKILSYV QKNGEESGDPQEVADLIYQLATKQHIKNLRYPIGKGIKLTLLFRSLFPWSAWESILKK KLFS*" /label="yusZ CDS" gene 2877071..2877913 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /label="yusZ gene" promotor_-35 2877443..2877449 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-35" promotor_-10 2877464..2877475 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-10" upshifts 2877472 /Source="Nicolas_upshifts" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="upshifts" promotor_-35 2877940..2877947 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2877956 /Source="Nicolas_upshifts" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2877959..2877978 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2878003..2878464 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 8709848, 21057011, 22194458, 24123749, 28434086" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 8709848, 21057011, 22194458, 24123749, 28434086; Product type f : factor" /codon_start=1 /transl_table=11 /product="metalloregulation DNA-binding stress protein" /protein_id="NP_391178.1" /db_xref="EnsemblGenomes-Gn:BSU32990" /db_xref="EnsemblGenomes-Tr:CAB15288" /db_xref="GOA:P37960" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="PDB:2CHP" /db_xref="SubtiList:BG10864" /db_xref="UniProtKB/Swiss-Prot:P37960" /translation="MKTENAKTNQTLVENSLNTQLSNWFLLYSKLHRFHWYVKGPHFF TLHEKFEELYDHAAETVDTIAERLLAIGGQPVATVKEYTEHASITDGGNETSASEMVQ ALVNDYKQISSESKFVIGLAEENQDNATADLFVGLIEEVEKQVWMLSSYLG*" /label="mrgA CDS" gene 2878003..2878464 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /label="mrgA gene" downshifts 2878440 /Source="Nicolas_upshifts" /id="D1704" /incds=0 /nref=234 /ntot=274 /MaxReadThrough="1.7919" /MaxDrop="8.26581" /score="36.5549876" /energy="-13.3" /TU="NA" /idTUdmin="U2583" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2878508..2879884) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423; Product type f: factor" /codon_start=1 /transl_table=11 /product="protease-associated chaperone for the extracytoplasmic folding and quality control of exported proteins" /protein_id="NP_391180.2" /db_xref="EnsemblGenomes-Gn:BSU33000" /db_xref="EnsemblGenomes-Tr:CAB15290" /db_xref="GOA:Q9R9I1" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14155" /db_xref="UniProtKB/Swiss-Prot:Q9R9I1" /translation="MDYRRDGQNDQHQTEPSHTEQQNTENQKLIGHSEQELLDAPVSY EAGRQETASALEMEKQETAVKKEKKRRAAWLSPILGGIIGGGLMLGIAPYLPSDQNQA TETASANKQVQSDNFTTAPITNASNIADMVEDLEPTIVGISNIQTSQNNTFGTGGGSS SESESGTGSGVIFKKDSDKAYIITNNHVVEGANKLTVTLYNGETETAKLVGSDTITDL AVLEISGKNVKKVASFGDSSQLRTGEKVIAIGNPLGQQFSGTVTQGIISGLNRTIDVD TTQGTVEMNVLQTDAAINPGNSGGPLINASGQVIGINSLKVSESGVESLGFAIPSNDV EPIVDQLLQNGKVDRPFLGVQMIDMSQVPETYQENTLGLFGDQLGKGVYVKEVQANSP AEKAGIKSEDVIVKLNGKDVESSADIRQILYKDLKVGDKTTIQVLRKGKTKTLNATLT KQTESSSS*" /label="htrB CDS" gene complement(2878508..2879884) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /label="htrB gene" downshifts complement(2878516) /Source="Nicolas_upshifts" /id="D1705" /incds=0 /nref=206 /ntot=257 /MaxReadThrough="1.84997" /MaxDrop="6.39104" /score="17.1953741" /energy="-11.2" /TU="U2586" /idTUdmin="U2586" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2879885..2880056) /Source="Nicolas_S_feature" /locus_tag="new_3385447_3385618_c" /HighExp="SMMPr, T-0.40H, T-1.10H, M9-tran, T-1.40H, T1.0H, T0.30H, T1.30H, Etha, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67259999999999998" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1268" promotor_-10 complement(2880037..2880056) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2880056) /Source="Nicolas_upshifts" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2880067..2880074) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2880117..2880136) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-10" misc_feature 2880127..2880146 /Source="Nicolas_upshift_promotors" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2880129 /Source="Nicolas_upshifts" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2880135) /Source="Nicolas_upshifts" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="upshifts" S_feature complement(2880137..2881200) /Source="Nicolas_S_feature" /locus_tag="new_3385699_3386762_c" /HighExp="T1.0H, T0.30H, T1.30H, C30, T2.0H, G135, G180, T2.30H, ferm, G150" /AntisenseName="cssR" /AntisenseCor="0.115381389160342" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1269" promotor_-35 complement(2880151..2880158) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-35" CDS 2880162..2880839 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type r: regulator" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component response regulator" /protein_id="NP_391181.1" /db_xref="EnsemblGenomes-Gn:BSU33010" /db_xref="EnsemblGenomes-Tr:CAB15291" /db_xref="GOA:O32192" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14131" /db_xref="UniProtKB/Swiss-Prot:O32192" /translation="MSYTIYLVEDEDNLNELLTKYLENEGWNITSFTKGEDARKKMTP SPHLWILDIMLPDTDGYTLIKEIKAKDPDVPVIFISARDADIDRVLGLELGSNDYISK PFLPRELIIRVQKLLQLVYKEAPPVQKNEIAVSSYRVAEDAREVYDENGNIINLTSKE FDLLLLFIHHKGHPYSREDILLKVWGHDYFGTDRVVDDLVRRLRRKMPELKVETIYGF GYRMMSS*" /label="cssR CDS" gene 2880162..2880839 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /label="cssR gene" CDS 2880836..2882191 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component sensor histidine kinase" /protein_id="NP_391182.2" /db_xref="EnsemblGenomes-Gn:BSU33020" /db_xref="EnsemblGenomes-Tr:CAB15292" /db_xref="GOA:O32193" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14132" /db_xref="UniProtKB/Swiss-Prot:O32193" /translation="MKNKPLAFQIWVVISGILLAISILLLVLFSNTLRDFFTNETYTT IENEQHVLTEYRLPGSIERRYYSEEATAPTTVRSVQHVLLPENEEASSDKDLSILSSS FIHKVYKLADKQEAKKKRYSADVNGEKVFFVIKKGLSVNGQSAMMLSYALDSYRDDLA YTLFKQLLFIIAVVILLSWIPAIWLAKYLSRPLVSFEKHVKRISEQDWDDPVKVDRKD EIGKLGHTIEEMRQKLVQKDETERTLLQNISHDLKTPVMVIRGYTQSIKDGIFPKGDL ENTVDVIECEALKLEKKIKDLLYLTKLDYLAKQKVQHDMFSIVEVTEEVIERLKWARK ELSWEIDVEEDILMPGDPEQWNKLLENILENQIRYAETKIEISMKQDDRNIVITIKND GPHIEDEMLSSLYEPFNKGKKGEFGIGLSIVKRILTLHKASISIENDKTGVTYRIAVP K*" /label="cssS CDS" gene 2880836..2882191 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /label="cssS gene" S_feature complement(2881290..2882218) /Source="Nicolas_S_feature" /locus_tag="new_3386852_3387780_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, ferm, C30, LPhT, T-1.10H, Lbstat" /AntisenseName="cssS" /AntisenseCor="0.27217686232372901" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigD, SigH, SigA" /TUshortPSig="1, 0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1270" downshifts 2882159 /Source="Nicolas_upshifts" /id="D1706" /incds=0 /nref=61 /ntot=203 /MaxReadThrough="0.95076" /MaxDrop="4.47937" /score="13.0972324" /energy="-9.7" /TU="NA" /idTUdmin="U2587" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2882219..2882383) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /experiment="publication(s) with functional evidences, PMID:21378193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21378193; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpxA degradation" /protein_id="YP_003097785.1" /db_xref="EnsemblGenomes-Gn:BSU33029" /db_xref="EnsemblGenomes-Tr:CAX52691" /db_xref="GOA:O32302" /db_xref="UniProtKB/Swiss-Prot:O32302" /translation="MRELDEMISRLRNRGIKVEKVKYPKQTLSEKKWVHQCKQPLKTN YRDFNGYSFT*" /label="spxO CDS" gene complement(2882219..2882383) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /label="spxO gene" promotor_-35 2882407..2882414 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2882428..2882447 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2882432..2882451) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2882438..2882550 /Source="Nicolas_S_feature" /locus_tag="new_3388000_3388112" /HighExp="dia5, Diami, T0.30H, T-0.40H, T0.0H, dia15, Salt, ferm, G135, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1271" upshifts 2882438 /Source="Nicolas_upshifts" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2882445) /Source="Nicolas_upshifts" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2882447..2882725) /Source="Nicolas_S_feature" /locus_tag="new_3388009_3388287_c" /HighExp="Etha, Gly, S2, Glucon, Pyr, G/S, S1, Lbstat, Cold, HiTm" /AntisenseName="yuxN" /AntisenseCor="-0.128326996122899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigH, SigA" /TUshortPSig="0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1272" promotor_-35 complement(2882465..2882472) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2882551..2883426 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391183.1" /db_xref="EnsemblGenomes-Gn:BSU33030" /db_xref="EnsemblGenomes-Tr:CAB15293" /db_xref="GOA:P40950" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG11072" /db_xref="UniProtKB/Swiss-Prot:P40950" /translation="MKEKEKLIIETALKLFAQKGYNSTSVQEIAKECKISKGAFYIYF PSKEALLLSMLNYYYDKTFTRILNIKTKGDSPRTAYRKQLTVLYENILEHKDFISMQL KEGSLPYTEEVEQCAKKIRQSSLQFHIDSLLNIYGKKAEPYTAELCFLIEGISQIYLE CMILLGYTVKPSQLADIIMNRIDDMVKGMSERNDKPFITLEEASSLFGPLTHGRPDPL TESIVKSLRDKINSLNTNSSLELSESLDILEAEMKKKTPKLAIIKGMIHNLTESEALA KDAEQLKYLLKQQHI*" /label="yuxN CDS" gene 2882551..2883426 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /label="yuxN gene" promotor_-10 complement(2882715..2882734) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2882725) /Source="Nicolas_upshifts" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2882727..2883268) /Source="Nicolas_S_feature" /locus_tag="new_3388289_3388830_c" /HighExp="LBGstat, Cold, S2, Glucon, S1, Pyr, G/S, C30, GM 10, GM-0.1" /AntisenseName="yuxN" /AntisenseCor="-0.341746670828522" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigH, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1273" promotor_-35 complement(2882748..2882755) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2883260..2883278) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2883268) /Source="Nicolas_upshifts" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2883270..2883399) /Source="Nicolas_S_feature" /locus_tag="new_3388832_3388961_c" /HighExp="S2, S1, G/S, Glucon, Pyr, T3.30H, M9-stat, BT, Cold, T4.0H" /AntisenseName="yuxN" /AntisenseCor="-0.30886083736579201" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1274" promotor_-35 complement(2883291..2883298) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2883401 /Source="Nicolas_upshifts" /id="D1707" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="3.14099" /MaxDrop="3.7614" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2589" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" downshifts complement(2883444) /Source="Nicolas_upshifts" /id="D1708" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="5.30537" /MaxDrop="3.29426" /score="-2.73895091" /energy="-13.6" /TU="U2593,U2594" /idTUdmin="U2591" /TUdmin="-1584" /isTUend="FALSE" /label="downshifts" CDS complement(2883462..2884850) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /EC_number="4.2.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:2509422, 3130545, 3923430, 9647666, 22914898, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509422, 3130545, 3923430, 9647666, 22914898, 28032445; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fumarate hydratase" /protein_id="NP_391184.1" /db_xref="EnsemblGenomes-Gn:BSU33040" /db_xref="EnsemblGenomes-Tr:CAB15294" /db_xref="GOA:P07343" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR005677" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10384" /db_xref="UniProtKB/Swiss-Prot:P07343" /translation="MEYRIERDTMGEVKVPADKFWGAQTQRSKENFKIGSEKMPMRVV KAFAILKRSTALANKRLGNLDAEKAEAIAAVCDDVLKGKYDDNFPLVVWQTGSGTQSN MNMNEVVANRATALLKEKNSDQTIHPNDDVNRSQSSNDTFPTAMHVAAVLAVYEQLVP ALDQLRNTLDEKAKAYNDIVKIGRTHLQDATPLTLGQEISGWVHMLDRSKEMILEATD KMRALAIGGTAVGTGINAHPEFGELVSEEITKLTGQTFSSSPNKFHALTSHDEITYAH GALKALAADLMKIANDVRWLASGPRCGIGEIVIPENEPGSSIMPGKVNPTQSEALTMI AAQIMGNDATIGFAASQGNFELNVFKPVIIYNFLQSVQLLSDGMNSFHDKCAVGIEPN KETIQENLSNSLMLVTALNPHIGYENAAKIAKLAHKEGLTLKEAALKLELLTEEQFNE MVKPEDMVKPKA*" /label="fumC CDS" gene complement(2883462..2884850) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /label="fumC gene" upshifts complement(2884874) /Source="Nicolas_upshifts" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2884879..2884897) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2884908..2884916) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2884917..2885102) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097786.1" /db_xref="EnsemblGenomes-Gn:BSU33049" /db_xref="EnsemblGenomes-Tr:CAX52692" /db_xref="InterPro:IPR025088" /db_xref="UniProtKB/Swiss-Prot:C0H3R3" /translation="MAQVRLAGKQEEIEQLIRSFEQHYDVSYTSKEYGRTNPKYKYSK DSRVYLELKLKSAKIEK*" /label="yvzF CDS" gene complement(2884917..2885102) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /label="yvzF gene" downshifts 2885106 /Source="Nicolas_upshifts" /id="D1709" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="1.13377" /MaxDrop="4.4478" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2595" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2885146..2885165) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2885155..2885161 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2885160) /Source="Nicolas_upshifts" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2885175..2885186 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2885178 /Source="Nicolas_upshifts" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2885181..2885184) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2885220..2886668 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the GerA germination receptor" /protein_id="NP_391185.2" /db_xref="EnsemblGenomes-Gn:BSU33050" /db_xref="EnsemblGenomes-Tr:CAB15295" /db_xref="GOA:P07868" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10385" /db_xref="UniProtKB/Swiss-Prot:P07868" /translation="MEQTEFKEYIHDNLALVLPKLKENDDLVKNKKMLANGLVFYYLY FSEMTDENKVSEAIKTLIKDEETLTLDQVKKRLDQLDARPVETAKKTIESILNGNCAV FINGLDKAYILTTGKKKTRSLTEPTTEKVVRGPKVAFVEDIDTNLALIRQRTSHPKLI TKKIMIGENKLKPAAIMYIEGKAKKSVIKEVKARLKNIQLEDIQDSGTLEELIEDNKY SPFPQIQNTERPDKVSSALFNGRVAILVDSSPFVLLVPVSLGILMQSPDDYYERWISA SLIRSLRFASIFITLFLSSIYITLVSFHQGLLPTALAVTISANRENVPFPPIFEALLM EVTIELLREAGLRLPNPLGQTIGLVGGVVIGQAAVEANLVSSILVIVVSVIALASFTV PQYGMGLSFRVLRFISMFSAAILGLYGIILFMLVVYTHLTRQTSFGSPYFSPNGFFSL KNTDDSIIRLPIKNKPKEVNNPNEPKTDSTET*" /label="gerAA CDS" gene 2885220..2886668 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /label="gerAA gene" S_feature complement(2886216..2888859) /Source="Nicolas_S_feature" /locus_tag="new_3391778_3394421_c" /HighExp="Cold, H2O2, G135, G180, Paraq, G150, Oxctl, T-5.40H, LBGstat, T-4.40H" /AntisenseName="gerAC" /AntisenseCor="-9.7163861003102397E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1275" CDS 2886637..2887734 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16740944, 16850406, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16740944, 16850406, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA; putative transporter" /protein_id="NP_391186.1" /db_xref="EnsemblGenomes-Gn:BSU33060" /db_xref="EnsemblGenomes-Tr:CAB15296" /db_xref="GOA:P07869" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10386" /db_xref="UniProtKB/Swiss-Prot:P07869" /translation="MSQKQTPLKLNTFQGISIVANTMLGAGLLTLPRALTTKANTPDG WITLILEGFIFIFFIYLNTLIQKKHQYPSLFEYLKEGLGKWIGSIIGLLICGYFLGVA SFETRAMAEMVKFFLLERTPIQVIILTFICCGIYLMVGGLSDVSRLFPFYLTVTIIIL LIVFGISFKIFDINNLRPVLGEGLGPIANSLTVVSISFLGMEVMLFLPEHMKKKKYTF RYASLGFLIPIILYILTYIIVVGALTAPEVKTLIWPTISLFQSFELKGIFIERFESFL LVVWIIQFFTTFVIYGYFAANGLKKTFGLSTKTSMVIIGITVFYFSLWPDDANQVMMY SDYLGYIFVSLFLLPFILFFIVALKRRITTK*" /label="gerAB CDS" gene 2886637..2887734 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /label="gerAB gene" CDS 2887731..2888852 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA" /protein_id="NP_391187.1" /db_xref="EnsemblGenomes-Gn:BSU33070" /db_xref="EnsemblGenomes-Tr:CAB15297" /db_xref="GOA:P07870" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG10387" /db_xref="UniProtKB/Swiss-Prot:P07870" /translation="MKIRILCMFICTLLLSGCWDSENIEELSLVIGIGLDKPDDENLE LTQQILVPKIISAKEGSSSDPTQLSITKGKTVHQMMRTSALKHKPTFSQHLRLILLSK SVIADQIGMDAIINQFVRDNGTRRSSYVFITNGRTKDIFNMNDEGEPASNVIYDLTEN NKVTIRTMEPVTLGEISEHLTSDDSFLIPHVGKENGKLAINGASIIKNKLWHRDLTPI EVQNISLFSGTVEGGVIDLKRDGHLFSYEVYSSNRKIKTAYKDGKFKFTVTRNIEGRL SEDWNPNEDSFKDSYIKSIEKTVEKRVHETVTSFITEKLQKEIKADVTGLGNEVRIHY PQKWKKISRKWDDDYFSNAEIDYRVNVIVRDFGTKGANK*" /label="gerAC CDS" gene 2887731..2888852 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /label="gerAC gene" CDS complement(2888860..2889495) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvqE] responding to cell wall stress" /protein_id="NP_391188.1" /db_xref="EnsemblGenomes-Gn:BSU33080" /db_xref="EnsemblGenomes-Tr:CAB15298" /db_xref="GOA:O32197" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14133" /db_xref="UniProtKB/Swiss-Prot:O32197" /translation="MIRVLLIDDHEMVRMGLAAFLEAQPDIEVIGEASDGSEGVRLAV ELSPDVILMDLVMEGMDGIEATKQICRELSDPKIIVLTSFIDDDKVYPVIEAGALSYL LKTSKAAEIADAIRAASKGEPKLESKVAGKVLSRLRHSGENALPHESLTKRELEILCL IAEGKTNKEIGEELFITIKTVKTHITNILSKLDVSDRTQAAVYAHRNHLVN*" /label="liaR CDS" gene complement(2888860..2889495) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /label="liaR gene" CDS complement(2889473..2890555) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /function="16.12: Sense" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LiaR(YvqC)] sensing cell wall stress" /protein_id="NP_391189.1" /db_xref="EnsemblGenomes-Gn:BSU33090" /db_xref="EnsemblGenomes-Tr:CAB15299" /db_xref="GOA:O32198" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR017202" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14134" /db_xref="UniProtKB/Swiss-Prot:O32198" /translation="MRKKMLASLQWRAIRMTTGISLLLFVCLISFMMFYYRLDPLVLL SSSWFGIPFILILLLISVTVGFASGYMYGNRLKTRIDTLIESILTFENGNFAYRIPPL GDDEIGLAADQLNEMAKRVELQVASLQKLSNERAEWQAQMKKSVISEERQRLARDLHD AVSQQLFAISMMTSAVLEHVKDADDKTVKRIRMVEHMAGEAQNEMRALLLHLRPVTLE GKGLKEGLTELLDEFRKKQPIDIEWDIQDTAISKGVEDHLFRIVQEALSNVFRHSKAS KVTVILGIKNSQLRLKVIDNGKGFKMDQVKASSYGLNSMKERASEIGGVAEVISVEGK GTQIEVKVPIFPEEKGENERDSSIID*" /label="liaS CDS" gene complement(2889473..2890555) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /label="liaS gene" CDS complement(2890552..2891277) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane component associated to the LiaRS two-component system" /protein_id="NP_391190.1" /db_xref="EnsemblGenomes-Gn:BSU33100" /db_xref="EnsemblGenomes-Tr:CAB15300" /db_xref="GOA:O32199" /db_xref="InterPro:IPR016975" /db_xref="InterPro:IPR024425" /db_xref="SubtiList:BG14135" /db_xref="UniProtKB/Swiss-Prot:O32199" /translation="MTKKQLLGLIIALFGISMFLQIIGIGDLLFWPLFFLIAGYFLKK YSRDWLGSVMYIFAAFLFLKNLFSITFNLFGYAFAAFLIYAGYRLIKGKPIFEPNEKQ VNLNKKEHHEPPKDVKHPDMRSFFIGELQMMKQPFDLNDLNVSGFIGDIKIDLSKAMI PEGESTIVISGVIGNVDIYVPSDLEVAVSSAVFIGDINLIGSKKSGLSTKVYAASTDF SESKRRVKVSVSLFIGDVDVKYV*" /label="liaF CDS" gene complement(2890552..2891277) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /label="liaF gene" CDS complement(2891311..2892183) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="sensor of antibiotic stress on the cell wall" /protein_id="NP_391191.2" /db_xref="EnsemblGenomes-Gn:BSU33110" /db_xref="EnsemblGenomes-Tr:CAB15301" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14136" /db_xref="UniProtKB/Swiss-Prot:O32200" /translation="MKKMLGKLLITAGILVFFAVVVKDVFAAGLGFINGTEADSASAS PRDIDSMVIESDSKDVRIIAEERSDISAGISGDSGKLFVTENKRKLELTVKEKEFQFL NGFNRSTLIVRLPYDYKGDLAVRTSSGDVSVAGNDHLALSGLNAVSASGNTSVTDVRI QDLKVKASSGDVSISNTVSKTAGIDLASGDANLVHVSGSLDVKMTSGDFNAVLKKVTG PVSVTLTSGDANVSLPQNGSFAVNALSASGDVSSPYSFADKGHKEQHHITGTQGSGRH PIDIKTDSGDLAIR*" /label="liaG CDS" gene complement(2891311..2892183) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /label="liaG gene" promotor_-10 complement(2892202..2892221) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2892222) /Source="Nicolas_upshifts" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2892236..2892239) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2892284..2892961) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23874669, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23874669, 24666271, 28546427; Product type f: factor" /codon_start=1 /transl_table=11 /product="modulator of liaIHGFSR (yvqIHGFEC) operon expression" /protein_id="NP_391192.1" /db_xref="EnsemblGenomes-Gn:BSU33120" /db_xref="EnsemblGenomes-Tr:CAB15302" /db_xref="GOA:O32201" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG14137" /db_xref="UniProtKB/Swiss-Prot:O32201" /translation="MVLKRIRDMFVASVHEGLDKMENPKVMLNQYVRDMESDIAKAKQ TIVKQHTIAYQFKKKYEEAAEVAGKRKNQAQLAFDAGEEELAKKALTEMKYLEGKAAE HKASYEQANSQLADLKEQLAALETKLQDVKDKKQALIARANAAKAKEHMNTTFDKIDS ESAYREFLRIENRIEEMEIRANYSKSAEAGTELTRKEFADDVEAEIEKMRTLSLQKSD QTKAANE*" /label="liaH CDS" gene complement(2892284..2892961) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /label="liaH gene" downshifts complement(2892300) /Source="Nicolas_upshifts" /id="D1710" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="3.84852" /MaxDrop="3.1352" /score="-8.3477012" /energy="-4.5" /TU="U2597" /idTUdmin="U2598" /TUdmin=1243 /isTUend="FALSE" /label="downshifts" CDS complement(2892988..2893368) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427; Product type s: structure" /codon_start=1 /transl_table=11 /product="membrane anchor for the phage-shock protein A homolog LiaH" /protein_id="NP_391193.1" /db_xref="EnsemblGenomes-Gn:BSU33130" /db_xref="EnsemblGenomes-Tr:CAB15303" /db_xref="GOA:O32202" /db_xref="SubtiList:BG14138" /db_xref="UniProtKB/Swiss-Prot:O32202" /translation="MKINKKTIGGFLLIVFGISVFFGGGSFGFIIPLAIGSLMTYAGI KRFAAGKTITGIIVGGIGAIMLICSLPFVVGIALAAAMVYYGWKLMKNGSADNGVSSF DPEPASAAYQSHFDDEWEEFLKKK*" /label="liaI CDS" gene complement(2892988..2893368) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /label="liaI gene" promotor_-10 complement(2893391..2893410) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2893411) /Source="Nicolas_upshifts" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2893425..2893428) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2893530..2894798) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15273097, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux protein" /protein_id="NP_391194.1" /db_xref="EnsemblGenomes-Gn:BSU33140" /db_xref="EnsemblGenomes-Tr:CAB15304" /db_xref="GOA:O32203" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14139" /db_xref="UniProtKB/Swiss-Prot:O32203" /translation="MVNLIESDSIWKRNFNYLFFSRIVKISGDMFAFNSILWFLIYDG KGAIGTALLIAVTFLPEAVLAPVTGPFMKQTTLKFWMYFSDLTRAAIVLIIPLCHFAG FSPLWFVMTLMIVHSATGAAYNPASIALIPQIVNEQGIQKANAVLQSSAQIVRLGAVT LCGAFLTFISPSYTMLIALVLYLVSGFLVLFIKYTAVESQSESAVVTQRGTYIGRLKR GFRLVRKHQILYPLAIYCIFMNFAAAPWEALSAVYVAEDLNGQPIVYSLLKATTAAGA FLLGFVLAKVKVNRYGLLFVTAGIIEGFAFFITGMNTFLPLVFFAAFTFGAAVSAVNV PEYTIIQTSVDSEDQPQVYAVIHMISNISIPAGAVICGYAANAFGSGKVIAVGGIVEI IAGIGILLFTKLAKAERSDLIKEREASVHL*" /label="yvqJ CDS" gene complement(2893530..2894798) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /label="yvqJ gene" downshifts complement(2893543) /Source="Nicolas_upshifts" /id="D1711" /incds=0 /nref=78 /ntot=164 /MaxReadThrough="0.70612" /MaxDrop="4.80625" /score="32.7496145" /energy="-12.9" /TU="NA" /idTUdmin="U2598" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2894832..2894851) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2894843) /Source="Nicolas_upshifts" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2894866..2894873) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2894969) /Source="Nicolas_upshifts" /id="D1712" /incds=0 /nref=33 /ntot=211 /MaxReadThrough="1.54601" /MaxDrop="4.92923" /score="51.1311697" /energy="-17.1" /TU="NA" /idTUdmin="U2599" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2894975..2895556) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /EC_number="2.5.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12869542, 14704351, 17588214, 19933577, 21514283; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP:cob(I)alamin adenosyltransferase" /protein_id="NP_391195.2" /db_xref="EnsemblGenomes-Gn:BSU33150" /db_xref="EnsemblGenomes-Tr:CAB15305" /db_xref="GOA:O34899" /db_xref="InterPro:IPR016030" /db_xref="InterPro:IPR029499" /db_xref="InterPro:IPR036451" /db_xref="PDB:1RTY" /db_xref="SubtiList:BG14140" /db_xref="UniProtKB/Swiss-Prot:O34899" /translation="MKLYTKTGDKGQTGLVGGRTDKDSLRVESYGTIDELNSFIGLAL AELSGQPGFEDLTAELLTIQHELFDCGGDLAIVTERKDYKLTEESVSFLETRIDAYTA EAPELKKFILPGGSKCASLLHIARTITRRAERRVVALMKSEEIHETVLRYLNRLSDYF FAAARVVNARSGIGDVEYERSAIVFRDRNSSES*" /label="yvqK CDS" gene complement(2894975..2895556) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /label="yvqK gene" CDS complement(2895579..2896907) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 transport system, ATPase component" /protein_id="NP_391196.1" /db_xref="EnsemblGenomes-Gn:BSU33160" /db_xref="EnsemblGenomes-Tr:CAB15306" /db_xref="GOA:O34631" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14141" /db_xref="UniProtKB/Swiss-Prot:O34631" /translation="MKAEGLSGGYGDSRLINNVSLTVEKGEFLGILGPNGSGKTTLLH LLTGTLPAKKGRVYLAGKLLADYKPKELAQIMAVLPQKMDQAFTFTVEETVAFGRYPF QTGLFRQQTEKGEAIVQEAMEQTGVADFAQKPIRELSGGEQQRVYLAQALAQQPRILF LDEPTNFLDLAYQKDLLDLIKRLTRESGLAAVSVFHDLNTASLYCDGLMFMKNGTAGP KQKPEYAVTEQSIKAVYDTDVTALVHQSSPKPMIVIQPEKDSVKRQSIPFEALLQAGR DDILLQTEIPLRTLSSTPIGAGFSWSRTLIHKRLPDQPDPIEGLTACLSESGFQLQET CAMASSERLDRFVYRTYEDGELSVFICVQTGFSIWILINGYAADQFFIKALMAAEAER TKVLGDGGGTGDILIAATQTQQSENIEQRLNQLIKKGTAECIKEAAELFE*" /label="yvrA CDS" gene complement(2895579..2896907) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /label="yvrA gene" CDS complement(2896907..2897968) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 15849754, 16850406, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 permease" /protein_id="NP_391197.1" /db_xref="EnsemblGenomes-Gn:BSU33170" /db_xref="EnsemblGenomes-Tr:CAB15307" /db_xref="GOA:O34451" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG14142" /db_xref="UniProtKB/Swiss-Prot:O34451" /translation="MRKAFTRIRLRNNRYAAYIIGFSFLAVSIILGISCGSLHIPIPA VFRVFWHQGFGGSIGSDDPMYTNIMMNIRLPRVVLAALVGAALSIAGAAFQGLLKNPL ADPYTLGVSSGASVGAVVTLFLGLHLPVIGGFTLPVLSVAAALATMAAVLFFSRLVHA SMSVSTLILTGVITNSFLGAFISLIIALTGDNLLPIVHWLLGSVSMRGWSYVILFLPF FLLGTILLIINGRELNVMTYGEDKAKLLGVSVQQRKMMILIAGSLLTGSAVAVSGTIG FVGLVIPHITRLLWGTDHRHLLPLSALLGAGFLVLADLLSRTIIEPIELPIGIITSLA GAPVFALILIRQHRGGRSL*" /label="yvrB CDS" gene complement(2896907..2897968) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /label="yvrB gene" CDS complement(2897931..2898875) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative lipoprotein binding vitamin B12" /protein_id="NP_391198.1" /db_xref="EnsemblGenomes-Gn:BSU33180" /db_xref="EnsemblGenomes-Tr:CAB15308" /db_xref="GOA:O34805" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG14143" /db_xref="UniProtKB/Swiss-Prot:O34805" /translation="MKKRAGIWAALLLAAVMLAGCGNPADQKDSKAKQKTEVFPVTID DASNQDVTIKKEPKKIVSLMPSNTEITYALGLGDKVVGVTTNDTYPKEVKKVEKVGDM NVNVEKVISLKPDLVLAHESSMSASADAIKQLKDAGITVLTVNDAQSFSEVYKSIEMI GEAGGAEKKADQLVKSMKSDLKDIQEKAKTISKDEEKSVFIEVSPDPDIYTTGKDTFM NEMLNVIHAKNAAADQTGWVQMTDEAIVKLNPDAIVTTDGVKAKAVEKRDGWSEINAV KHHRVYDVDPDLVTRSGPRLIEGVEELAESIYPDTFKE*" /label="yvrC CDS" gene complement(2897931..2898875) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /label="yvrC gene" S_feature complement(2898876..2899145) /Source="Nicolas_S_feature" /locus_tag="new_3404438_3404707_c" /HighExp="LBGtran, LBGexp, Etha, LPh, S3, Lbexp, G180, dia0, HPh, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.956, 1" /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1276" misc_RNA complement(2898984..2899114) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /product="putative coenzyme B12 (AdoCbl) riboswitch" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 17038623, 21140903, 25917914; Product type n: RNA" /function="16.3: Control" /label="srbL RNA" gene complement(2898984..2899114) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /label="srbL gene" promotor_-10 complement(2899122..2899141) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2899145) /Source="Nicolas_upshifts" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2899147..2900074) /Source="Nicolas_S_feature" /locus_tag="new_3404709_3405636_c" /HighExp="Etha, B60, Sw, M9-stat, B36, C30, C90, Salt, G135, Gly" /AntisenseName="yvrD" /AntisenseCor="1.5286196477289399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1277" promotor_-35 complement(2899157..2899164) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2899207..2899214 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2899229..2899248 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2899233 /Source="Nicolas_upshifts" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="upshifts" CDS 2899273..2900064 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9922248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391199.1" /db_xref="EnsemblGenomes-Gn:BSU33190" /db_xref="EnsemblGenomes-Tr:CAB15309" /db_xref="GOA:O34782" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14144" /db_xref="UniProtKB/Swiss-Prot:O34782" /translation="MDLQLKEKLVLITGSTSGIGKAAAKSFLQEGAAVIVNGRKQETV DRTIEELSGYGTVHGAAADLSKTDEAAAFIEKVNEIGDIDILVNNLGFFEVKDFADVT DEEWNQYFEVNVMSAVRTSRHFLPKMLAKNSGRILNIASEAGVKPLPTMIPYSMTKTA LISLSRGMAEMTKGTNVTVNSVLPGPTWTEGVASYMEGAAQAAGQDTDTFIKDYFKVN EPTSLIQRYATAEEVANTIVFLASDAASAINGTAQRVEGGIIRSL*" /label="yvrD CDS" gene 2899273..2900064 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /label="yvrD gene" downshifts 2899935 /Source="Nicolas_upshifts" /id="D1713" /incds=1 /nref=2 /ntot=89 /MaxReadThrough="6.202" /MaxDrop="3.35017" /score="36.8938178" /energy="-12" /TU="U2600" /idTUdmin="U2600" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 2900045 /Source="Nicolas_upshifts" /id="D1714" /incds=0 /nref=105 /ntot=218 /MaxReadThrough="2.44739" /MaxDrop="6.33457" /score="36.8938178" /energy="-12" /TU="NA" /idTUdmin="U2600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2900102..2900980) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar lactone lactonase" /protein_id="NP_391200.1" /db_xref="EnsemblGenomes-Gn:BSU33200" /db_xref="EnsemblGenomes-Tr:CAB15310" /db_xref="GOA:O34940" /db_xref="InterPro:IPR005511" /db_xref="InterPro:IPR011042" /db_xref="InterPro:IPR013658" /db_xref="SubtiList:BG14145" /db_xref="UniProtKB/Swiss-Prot:O34940" /translation="MDAVLEADTRAVIGEGPLWDEENGRLYWVDILGSELHIFDPEEK INRSIKFKSFVTALAKYSKDELIMTMKDGFYLYHLRDDSLEKIKQPKDMHESLRFNDA KCDPYGRLWAGTTSMEGEQKQASLYRLNLDGSLVKIKDQVSTSNGLDWDRERNLMYYI DTPTQEIVRYSYDPQSGDVSNPEPVYRFDQSDGLPDGMTIDQNGMLWVALFGGSRVVH IDPFQKKEINSISVPAKYVTCCAFGGRDLKTLYITTATEQMTEKERYEQPHAGGLFSA QLETGGYQPVPFAGDV*" /label="yvrE CDS" gene complement(2900102..2900980) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /label="yvrE gene" downshifts complement(2900119) /Source="Nicolas_upshifts" /id="D1715" /incds=0 /nref=31 /ntot=260 /MaxReadThrough="7.17016" /MaxDrop="5.74101" /score="29.8014794" /energy="-12" /TU="U2601" /idTUdmin="U2602" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2901004..2901022) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2901023) /Source="Nicolas_upshifts" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2901036..2901042) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2901052..2902794) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrH)]" /protein_id="NP_391201.2" /db_xref="EnsemblGenomes-Gn:BSU33210" /db_xref="EnsemblGenomes-Tr:CAB15311" /db_xref="GOA:O34989" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14146" /db_xref="UniProtKB/Swiss-Prot:O34989" /translation="MRLRWKFLFHFFGQMLIVILLLTVMLVASFFYLDARFSDAESNS GLTKATTDTLEAYLDVNEDGTWEVDNFLKKSVDKQHGWMQIIDSEGNTDYSYGVPKDV PGTYTKKELLSIYKTKKLHNYKLNYWAINIEDKSYLLLSGWKSKSEQLLTSVEKREQK IDSLAHYKSSTIDYIKRKKGAIYLLDSNGKILDSINSTKSERKTMNQLELLKYSSKPW NYKREISVKILNKDRWMVATVPNPVYVTDQEFNKSFLKVVLKAMFLVMAVLFMYIIWM TVWYMFRFGLPIFHTIRWLVNLSKGKLEEPRNREGRPVSKNKKGKIKQPYRFFGEIFE SMDQLTETLRRDKRNREKIQATREEWIAGLSHDLKTPLSSIYGYSMMLESKQYDWSPE EVKEMGQVVREKSEYMSKLIEDLNLTYRLKNDALPIERKLTSLIPFFKNVIEDFKKNP FSEGYDISFVSKEEHIEFALDEAWFRRILENLLGNAVKHNGKGTEIQVILEQTKNHIS LKVKDNGKGMDEETITHLFNRYYRGTNTKDSTAGTGLGLAIAKELVHLHNGTIHVNSR TNIGTVITILFKKQ*" /label="yvrG CDS" gene complement(2901052..2902794) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /label="yvrG gene" CDS complement(2902791..2903504) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrG)]" /protein_id="NP_391202.2" /db_xref="EnsemblGenomes-Gn:BSU33221" /db_xref="EnsemblGenomes-Tr:CAB15312" /db_xref="GOA:P94504" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12452" /db_xref="UniProtKB/Swiss-Prot:P94504" /translation="MENASILIVDDEKAIVDMIKRVLEKEGYRNILDAASAEEAIPVV KANKVDLIVLDVMMGGMSGFEACTLIREYSDAPIFFLTARSSDADKLSGFAVGADDYI TKPFNPLELAARIRAHLKRTYQSKETSSNQTYTYDYFTFSPQNAELIVGGEAVACSAQ LLQLLQYFCEHPNVVLSKDQIYEKVWGYPSYGDNNTVMVHIRKLREKIERDPSNPEYI VTVRGLGYRFIPNPEGKRS*" /label="yvrH CDS" gene complement(2902791..2903504) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /label="yvrH gene" misc_feature complement(2903535..2903554) /Source="Nicolas_upshift_promotors" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2903553) /Source="Nicolas_upshifts" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="upshifts" CDS complement(2903657..2903896) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sigma-O" /protein_id="YP_003097787.1" /db_xref="EnsemblGenomes-Gn:BSU33222" /db_xref="EnsemblGenomes-Tr:CAX52693" /db_xref="GOA:C0H3R4" /db_xref="UniProtKB/Swiss-Prot:C0H3R4" /translation="MDGQFEQKKKQKDETYDIEHLIACFSPMIRKKLSNTSYQEREDL EQELKIKMFEKADMLLCQDVPGFWEFILYMVDENS*" /label="rsoA CDS" gene complement(2903657..2903896) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /label="rsoA gene" downshifts complement(2903664) /Source="Nicolas_upshifts" /id="D1716" /incds=0 /nref=4 /ntot=30 /MaxReadThrough="2.45068" /MaxDrop="3.82244" /score="12.6471586" /energy="-8.2" /TU="NA" /idTUdmin="U2605" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2903892..2903910) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2903900..2904430) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16306698, 18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16306698, 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="alternative sigma factor" /protein_id="NP_391203.2" /db_xref="EnsemblGenomes-Gn:BSU33230" /db_xref="EnsemblGenomes-Tr:CAB15313" /db_xref="GOA:O34843" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14147" /db_xref="UniProtKB/Swiss-Prot:O34843" /translation="MKHPIVKHFLSNPQHYRLFKNVMESPNEKDARSLDELFKQFYKE IRIVKYMNSMIRIFSIDFDKRVRKNQKRYPLTVDHPEAGDRLSSETGSDAFEEFLDRQ DDLSQHVQDYQLYQAIQKLTDKQKSVLTKVYLHGATMQEIADSLGESRQNISNIHKKG LENIRKQLAAQKKGEK*" /label="sigO CDS" gene complement(2903900..2904430) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /label="sigO gene" upshifts complement(2903901) /Source="Nicolas_upshifts" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2903925..2903931) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2904433..2904452) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2904440) /Source="Nicolas_upshifts" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" CDS 2904445..2904783 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in oxalate decarboxylase expression" /protein_id="YP_003097788.1" /db_xref="EnsemblGenomes-Gn:BSU33239" /db_xref="EnsemblGenomes-Tr:CAX52694" /db_xref="InterPro:IPR024419" /db_xref="UniProtKB/Swiss-Prot:C0H3R5" /translation="MTVKDFDSPSNRLPTKLNEGKQKKVNYYFPPSVFQNTLQQFTFY RFSSLTYMTAEKEGRYFPMDQVFIEEVVKQIGNLGFPALIAMYLLTRFEKKFDQLIEL MTELKDHAKK*" /label="yvrJ CDS" gene 2904445..2904783 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /label="yvrJ gene" promotor_-35 complement(2904467..2904474) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2904483..2904502) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2904495) /Source="Nicolas_upshifts" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2904517..2904523) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2904529..2904629 /Source="Nicolas_upshift_promotors" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="promotor_no_box" upshifts 2904589 /Source="Nicolas_upshifts" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="upshifts" promotor_no_box 2904757..2904857 /Source="Nicolas_upshift_promotors" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2904817..2904903 /Source="Nicolas_S_feature" /locus_tag="new_3410379_3410465" /HighExp="T5.0H, T4.0H, T3.30H, Lbstat, T3.0H, nit, T2.0H, T2.30H, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.317" /TUlongSig="Sig-" /TUlongPSig="0.278" /label="S1278" upshifts 2904817 /Source="Nicolas_upshifts" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="upshifts" CDS 2904904..2906061 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase" /protein_id="NP_391204.1" /db_xref="EnsemblGenomes-Gn:BSU33240" /db_xref="EnsemblGenomes-Tr:CAB15314" /db_xref="GOA:O34714" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="PDB:1J58" /db_xref="PDB:1L3J" /db_xref="PDB:1UW8" /db_xref="PDB:2UY8" /db_xref="PDB:2UY9" /db_xref="PDB:2UYA" /db_xref="PDB:2UYB" /db_xref="PDB:2V09" /db_xref="PDB:3S0M" /db_xref="PDB:4MET" /db_xref="PDB:5HI0" /db_xref="SubtiList:BG14148" /db_xref="UniProtKB/Swiss-Prot:O34714" /translation="MKKQNDIPQPIRGDKGATVKIPRNIERDRQNPDMLVPPETDHGT VSNMKFSFSDTHNRLEKGGYAREVTVRELPISENLASVNMRLKPGAIRELHWHKEAEW AYMIYGSARVTIVDEKGRSFIDDVGEGDLWYFPSGLPHSIQALEEGAEFLLVFDDGSF SENSTFQLTDWLAHTPKEVIAANFGVTKEEISNLPGKEKYIFENQLPGSLKDDIVEGP NGEVPYPFTYRLLEQEPIESEGGKVYIADSTNFKVSKTIASALVTVEPGAMRELHWHP NTHEWQYYISGKARMTVFASDGHARTFNYQAGDVGYVPFAMGHYVENIGDEPLVFLEI FKDDHYADVSLNQWLAMLPETFVQAHLDLGKDFTDVLSKEKHPVVKKKCSK*" /label="oxdC CDS" gene 2904904..2906061 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /label="oxdC gene" downshifts 2906047 /Source="Nicolas_upshifts" /id="D1717" /incds=0 /nref=11 /ntot=87 /MaxReadThrough="4.83038" /MaxDrop="4.39135" /score="2.61432951" /energy="-9.4" /TU="U2607" /idTUdmin="U2607" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 2906122..2906532 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18573182, 19047353, 26651345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18573182, 19047353, 26651345; Product type f: factor" /codon_start=1 /transl_table=11 /product="acid stress-sensitive anti sigma factor" /protein_id="NP_391205.1" /db_xref="EnsemblGenomes-Gn:BSU33250" /db_xref="EnsemblGenomes-Tr:CAB15315" /db_xref="GOA:O34686" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14149" /db_xref="UniProtKB/Swiss-Prot:O34686" /translation="MKHQNPSKRLLRLSIKYLLAAAAVVLTYFAVIYILFSLAGTSYR SAAHVLLFAVVFLVLGLCFEPFERLMIHSFTFFKTGKRLFILLAGIVQLLFLWMTAHT TDQLISDIWLSTTEEMIVAAVFLILDKCNSALPS*" /label="rsiO CDS" gene 2906122..2906532 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /label="rsiO gene" downshifts 2906531 /Source="Nicolas_upshifts" /id="D1718" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.57216" /MaxDrop="3.72691" /score="-9.50136752" /energy="-7.4" /TU="NA" /idTUdmin="U2607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2906566..2907795) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391207.3" /db_xref="EnsemblGenomes-Gn:BSU33260" /db_xref="EnsemblGenomes-Tr:CAB15317" /db_xref="GOA:P46324" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG11368" /db_xref="UniProtKB/Swiss-Prot:P46324" /translation="MLEHIRISFQSIFSHKLRSILTMLGVIIGIAAIIAIVSMLKGQS EQLKQSMIGMGNNAINVVYQPSGGEEESGGPQVSYASAPPVAEETVKAIKSDPMVKGL SLYYLSEGASVFHLTNVSYPQVYGVDDDYFDMFPIRITEGRKLTENDLNSTHQVVMIN EAVRDELFPDGEALHKSIEMNGVPFKVVGVFKEKNQQESMFEGDYANPVLYVPKKVWP LIEGFDAPTQIAVQADSSEHIQEAGVMAADLLNQGLSEAELEKAEYSVMDLQEIAQEV ESFNQSFALLLGGIASISLLVGGIGVMNIMLVSVTERTREIGIKKALGAKRRVILFQF LTEAVVLTSIGGILGVLAGFGIAKLLTVIFPMPFIVSIPAVVGALIFSMAVGIIFGLL PSIKASKLQPVDALRYE*" /label="yvrN CDS" gene complement(2906566..2907795) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /label="yvrN gene" downshifts complement(2906583) /Source="Nicolas_upshifts" /id="D1719" /incds=0 /nref=10 /ntot=218 /MaxReadThrough="2.36812" /MaxDrop="4.29282" /score="13.74435" /energy="-11.3" /TU="NA" /idTUdmin="U2608" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2907788..2908477) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544226, 22517742; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391208.2" /db_xref="EnsemblGenomes-Gn:BSU33270" /db_xref="EnsemblGenomes-Tr:CAB15318" /db_xref="GOA:O34979" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14151" /db_xref="UniProtKB/Swiss-Prot:O34979" /translation="MLTLNNISKSYKLGKEEVPILKHINLTVQAGEFLAIMGPSGSGK STLMNIIGCLDRPTSGTYTLDQIDILKGKDGALAEIRNESIGFVFQTFHLLPRLTALQ NVELPMIYNKVKKKERRQRAYEALEKVGLKDRVSYKPPKLSGGQKQRVAIARALVNQP RFILADEPTGALDTKSSEQILALFSELHREGKTIIMITHDPDVAKKADRTVFIRDGEL VLDERGDISHA*" /label="yvrO CDS" gene complement(2907788..2908477) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /label="yvrO gene" CDS complement(2908461..2909654) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter membrane fusion component" /protein_id="NP_391209.1" /db_xref="EnsemblGenomes-Gn:BSU33280" /db_xref="EnsemblGenomes-Tr:CAB15319" /db_xref="GOA:O35007" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG14152" /db_xref="UniProtKB/Swiss-Prot:O35007" /translation="MSKKKKWLIGGAICAGVLVLAGIGAGGFYFFTHMNQVAVSSEPY AESVAVYMGGDSESGQTFSGKVEPEKQQKVYIDSEKGSIKKTYVKEGDQVKKGDKLFE YEGEDHSDEVEQANLQIEMTNLQINRLQKSITETEKKLKVAGKEEKNQLQDELDQTNF DLKTSQLELKQHQKELAGLTKNKGSNVITSKHDGIVQSVNQDIADGATGDQAAGPYIQ IVSTGKYLVKSQINELLMDTIKKGSKVRVTLKTGGEGEWKGKVTSIGKLPAGAGEGEE SESFADEEMNPQSSNYPFTILLDSHKGLEVGYHVNIEVMSDNADADTIKLPSDMVIQD DGEPYVWKADENHKAVKQPVEIGETDENDMVEIKSGLTPEDYVIYPDPAVKEGKQVTV NADTE*" /label="yvrP CDS" gene complement(2908461..2909654) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /label="yvrP gene" promotor_-10 complement(2909698..2909717) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2909711) /Source="Nicolas_upshifts" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2909732..2909739) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2909825..2910634) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ATP-binding protein)" /protein_id="NP_391210.1" /db_xref="EnsemblGenomes-Gn:BSU33290" /db_xref="EnsemblGenomes-Tr:CAB15335" /db_xref="GOA:P49938" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11390" /db_xref="UniProtKB/Swiss-Prot:P49938" /translation="MNSLSTEQLGIGYGDRVIVEDLNISIPKGKITTLIGPNGCGKST ILKTMSRIMRSHAGAVYLNGKAIHKMSTKDIAKDMAILPQTPEAPSGLTVHELVSYGR FPHQSGFGRLNDEDRRIIKWALEETGMAEYAERPIEALSGGQRQRVWIAMALAQGTEL LLLDEPTTYLDLAHQLEILQLLDRLNKEQGRTILMVIHDLNHAARFSHYMIALKKGTV IKEGTALEVMTPDILKQVFQIDAEIVTDPRTNKPVCLTYDLIKNEKELVTV*" /label="fhuC CDS" gene complement(2909825..2910634) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /label="fhuC gene" downshifts complement(2909842) /Source="Nicolas_upshifts" /id="D1720" /incds=0 /nref=190 /ntot=245 /MaxReadThrough="1.31294" /MaxDrop="6.48454" /score="40.5986253" /energy="-11" /TU="NA" /idTUdmin="U2610" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2909981..2909990 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2910003..2910022 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2910007 /Source="Nicolas_upshifts" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2910650..2911660) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251, 15849754, 16850406, 24362930; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391211.1" /db_xref="EnsemblGenomes-Gn:BSU33300" /db_xref="EnsemblGenomes-Tr:CAB15336" /db_xref="GOA:P49937" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11391" /db_xref="UniProtKB/Swiss-Prot:P49937" /translation="MKTKTNKPLIVMAVTFLLIVVVFFISLNLGVIKIAPLKTLQVFF GQGTARDELVLFEFRLPRIILSLLVGAGISVAGAILQSVSQNELAEPGILGINAGGSL AVVLFIYFFQGSASDLSFFGTFMLPFSALAGAILAAFLIYILAWKKGVTPIRLILVGI GVNAGFNALLLIFQLKMDPHDFMQAAVWISGSIWGANWNMIWAILPWIVILLLFTLYK ARYLNIMQLGDQLATGLGTAVEKERRILLLAAVTLAASCVAAAGGIAFLGLIAPHVAR RLTGPRHQTLIPVSAFIGSFLFLLADTLARNVLAPSEIPVGLVISVLGAPYFIYLLMK AN*" /label="fhuG CDS" gene complement(2910650..2911660) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /label="fhuG gene" CDS complement(2911660..2912814) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 15849754, 16850406, 24362930; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391212.1" /db_xref="EnsemblGenomes-Gn:BSU33310" /db_xref="EnsemblGenomes-Tr:CAB15337" /db_xref="GOA:P49936" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11389" /db_xref="UniProtKB/Swiss-Prot:P49936" /translation="MHFHFCSKHSIKSAEKSDILKQQLIIIISNRKEVRQLSQHKNIR TASEEIQWTSRTYGAVIVLIAGLCLLCLGAFLSISLGAADIHLRTVWEAIFHYQPTKT SHQIIHDLRLPRTAAAALVGALLAVSGAIMQGMTRNPLAEPSIMGVTSGSAFAVSIAF AFFPGLSAMGLVLWSFAGAGLGASTVMGIGMFSRGGLTPVKLALAGTAVTYFFTGIST AIAIRFDVAQDISFWYAGGVAGVKWSGVQLLLIAGAVGLTLAFFIARSVTVLSLGDDL AKGLGQYTSAVKLVGMLIVVILTGAAVSIAGTIAFIGLIIPHITRFLVGVDYRWIIPC SAVLGAVLLVFADIAARLVNAPFETPVGALTSLIGVPFFFYLARRERRGL*" /label="fhuB CDS" gene complement(2911660..2912814) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /label="fhuB gene" promotor_-10 complement(2912747..2912766) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2912764) /Source="Nicolas_upshifts" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2912778..2912785) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2912826..2912833 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2912848..2912867 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2912857 /Source="Nicolas_upshifts" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2912912..2913859 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 26919525; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ferrichrome-bindinglipoprotein)" /protein_id="NP_391213.1" /db_xref="EnsemblGenomes-Gn:BSU33320" /db_xref="EnsemblGenomes-Tr:CAB15338" /db_xref="GOA:P37580" /db_xref="InterPro:IPR002491" /db_xref="PDB:3G9Q" /db_xref="PDB:3HXP" /db_xref="SubtiList:BG10828" /db_xref="UniProtKB/Swiss-Prot:P37580" /translation="MTHIYKKLGAAFFALLLIAALAACGNNSESKGSASDSKGAETFT YKAENGNVKIPKHPKRVVVMADGYYGYFKTLGINVVGAPENVFKNPYYKGKTNGVENI GDGTSVEKVIDLNPDLIIVWTTQGADIKKLEKIAPTVAVKYDKLDNIEQLKEFAKMTG TEDKAEKWLAKWDKKVAAAKTKIKKAVGDKTISIMQTNGKDIYVFGKDFGRGGSIIYK DLGLQATKLTKEKAIDQGPGYTSISLEKLPDFAGDYIFAGPWQSGGDDGGVFESSIWK NLNAVKNGHVYKMDPIGFYFTDPISLEGQLEFITESLTK*" /label="fhuD CDS" gene 2912912..2913859 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /label="fhuD gene" downshifts 2913835 /Source="Nicolas_upshifts" /id="D1721" /incds=0 /nref=168 /ntot=245 /MaxReadThrough="3.82329" /MaxDrop="5.73183" /score="11.0136807" /energy="-12.1" /TU="U2611" /idTUdmin="U2611" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 2913879 /Source="Nicolas_upshifts" /id="D1722" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="3.01143" /MaxDrop="4.08479" /score="11.0136807" /energy="-12.1" /TU="NA" /idTUdmin="U2611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 2914033 /Source="Nicolas_upshifts" /id="D1723" /incds=0 /nref=8 /ntot=87 /MaxReadThrough="0.219110000000001" /MaxDrop="3.67928" /score="7.53231618" /energy="-13.7" /TU="NA" /idTUdmin="U2611" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(2914094..2915503) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14627808, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lysine permease" /protein_id="NP_391214.1" /db_xref="EnsemblGenomes-Gn:BSU33330" /db_xref="EnsemblGenomes-Tr:CAB15339" /db_xref="GOA:O32204" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG14154" /db_xref="UniProtKB/Swiss-Prot:O32204" /translation="MEQTKKWGFWLLTAFVVGNMVGSGIFSLPSSLASIASPFGATSA WLLTGAGVLMIALVFGHLSIRKPELTAGPQSYARALFSDPKKGNAAGFTMVWGYWVAS WISNVAIITSLAGYLTSFFPILVDKREMFSIGGQEVTLGQLLTFAVCTILLWGTHAIL VASINGASKLNFVTTLSKVLGFVFFIVAGLFVFQTSLFGHFYFPVQGENGTSIGIGGQ VHNAAISTLWAFVGIESAVILSGRARSQRDVKRATITGLLIALSIYIIVTLITMGVLP HDKLVGSEKPFVDVLYAIVGNAGSVIMALLAILCLFGTMLGWILLGSEVPYQAAKAGD FPAFFAKTNKKGSPVIALIITNVMSQVFIFSVISRTISDAFTFLTTAATLAYLIPYLV SAIYSLKVVIKGETYDQLKGSRVRDGLIAILACAYSVFVIVTGTADLTTFILGIGLFF VGLIVYPFVSNKFQKEKQA*" /label="lysP CDS" gene complement(2914094..2915503) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /label="lysP gene" downshifts complement(2914109) /Source="Nicolas_upshifts" /id="D1724" /incds=0 /nref=168 /ntot=213 /MaxReadThrough="0.441040000000001" /MaxDrop="6.03347" /score="23.064706" /energy="-13.7" /TU="NA" /idTUdmin="U2613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2914921..2914925 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2914943..2914959 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2914950 /Source="Nicolas_upshifts" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="upshifts" S_feature 2914957..2915924 /Source="Nicolas_S_feature" /locus_tag="new_3420519_3421486" /HighExp="S3, S4, S7, S5, S8, S6, Etha, M9-stat, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="7.6401427420847101E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.4" /TUlongSig="NA" /TUlongPSig="NA" /label="S1279" downshifts complement(2915605) /Source="Nicolas_upshifts" /id="D1725" /incds=0 /nref=1 /ntot=43 /MaxReadThrough="5.98281" /MaxDrop="3.61093" /score="-2.14086757" /energy="-5" /TU="U2613,U2614" /idTUdmin="U2614" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" misc_RNA complement(2915607..2915786) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22416067; Product type n: RNA" /label="kswB RNA" gene complement(2915607..2915786) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /label="kswB gene" promotor_-10 complement(2915816..2915833) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2915827) /Source="Nicolas_upshifts" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2915848..2915855) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2915881 /Source="Nicolas_upshifts" /id="D1726" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.6441" /MaxDrop="3.53891" /score="-0.527038766" /energy="-4.8" /TU="U2612" /idTUdmin="U2612" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(2915903..2916043) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054593.1" /db_xref="EnsemblGenomes-Gn:BSU33340" /db_xref="EnsemblGenomes-Tr:CAE01467" /db_xref="GOA:Q7WY58" /db_xref="InterPro:IPR014220" /db_xref="SubtiList:BG14174" /db_xref="UniProtKB/Swiss-Prot:Q7WY58" /translation="MGFFNKDKGKRSEKEKNVIQGALEDAGSALKDDPLQEAVQKKKN NR*" /label="sspJ CDS" gene complement(2915903..2916043) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /label="sspJ gene" downshifts complement(2915913) /Source="Nicolas_upshifts" /id="D1727" /incds=0 /nref=40 /ntot=87 /MaxReadThrough="4.06523" /MaxDrop="5.5784" /score="-1.94521013" /energy="-14.5" /TU="U2614" /idTUdmin="U2614" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" upshifts complement(2916071) /Source="Nicolas_upshifts" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="upshifts" S_feature complement(2916073..2916661) /Source="Nicolas_S_feature" /locus_tag="new_3421635_3422223_c" /HighExp="S6, S8, S7, S5, BT, G135, Diami, G180, LBGstat, S4" /AntisenseName="yvsG" /AntisenseCor="0.46604658967097301" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1280" promotor_-10 complement(2916076..2916087) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-10" promotor_-35 complement(2916101..2916107) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-35" promotor_-35 2916133..2916140 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2916154 /Source="Nicolas_upshifts" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2916156..2916175 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2916210..2916692 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_391215.1" /db_xref="EnsemblGenomes-Gn:BSU33350" /db_xref="EnsemblGenomes-Tr:CAB15340" /db_xref="GOA:O32205" /db_xref="InterPro:IPR007404" /db_xref="InterPro:IPR016956" /db_xref="SubtiList:BG14153" /db_xref="UniProtKB/Swiss-Prot:O32205" /translation="MTGKTHIMGGIASCTAAAYYYGFDPVLMAASGAVGALIPDICHT QSKIGRKFPILSKVVSSVFGHRTFTHSLLFMLIMFFITSTYIPDKNISAGLMIGMASH LILDAWTVNGIKLLFPSTIRVRLPLYMKTGSFSEQLVLAGLTLASCYYFYMLFHGRMF *" /label="yvsG CDS" gene 2916210..2916692 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /label="yvsG gene" promotor_-35 2916706..2916713 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2916727..2916746 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2916739 /Source="Nicolas_upshifts" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2916792..2918645 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="primase of polyglycerolphosphate lipoteichoic acid (LTA) synthesis" /protein_id="NP_391216.1" /db_xref="EnsemblGenomes-Gn:BSU33360" /db_xref="EnsemblGenomes-Tr:CAB15341" /db_xref="GOA:O32206" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG14092" /db_xref="UniProtKB/Swiss-Prot:O32206" /translation="MKGTFFHNQRFLCFSILFMWIKTYVIYKLGFDLQIDTLLEELML LVNPLSFILPLFGIGLFLKENKQRAFLLIANLVLTVILISNTIFYGFYIDFITIPVLF QASNMSDMGSSVKELFHPLFIALFVDLVFLLLFARKTKHPQTKAAPHTIKRYYAASCG MLLCTLALAEVQQPKLLAHSFDREMLVKSIGLFQFHIYDTISQTVNISAKAFADEDSI TAIKNYTEADYSKPDQSKFGLAKGRNVIFVTLESTQSFVLNEKVNGKEITPFMNDLIK KSYSFDHFYQQTEQGKTSDSEFIVANSLYPSLSGAVFFTKSDHQFHTMYKSLKQHDYY SAVFHANHKTFWNRDVMYDTFGIDRFFDVDDFHVTPGTSTSWGLKDKEFLEQSAKKLK SLPQPFYSSFITLTNHFPFEIDEKDQLIDEFDSSSDLLNRYVTTVRYEDEALKHFIKK LKDEGLYENSMIVFMGDHYGISEAHNEAMAEFLGKDEITPYDNVQLQRVPFIIHIPGI TDQQPETIPDAGGQVDVRPTLMHLLGVETKGDIQFGNDLLSGDRTPFAVLRNGSFITN DYVYTKNTCYSQKTGEVLEDQDACLPYKEKANEELSLSDKILNGDLLRFSE*" /label="ltaSP CDS" gene 2916792..2918645 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /label="ltaSP gene" downshifts 2918631 /Source="Nicolas_upshifts" /id="D1728" /incds=0 /nref=30 /ntot=171 /MaxReadThrough="1.18268" /MaxDrop="3.6959" /score="21.1397957" /energy="-10.5" /TU="NA" /idTUdmin="U2615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2918673..2919599) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative molybdate binding regulator" /protein_id="NP_391217.1" /db_xref="EnsemblGenomes-Gn:BSU33370" /db_xref="EnsemblGenomes-Tr:CAB15342" /db_xref="GOA:O32207" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010093" /db_xref="InterPro:IPR024370" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14093" /db_xref="UniProtKB/Swiss-Prot:O32207" /translation="MNETSSYTIEEVAGLLKVSKLTVYDLIKKGVLPAYRVGRQMRVD EEDLKQYKTNMRMSQPIAAKEAPKQVQEAEPDGRPNVMISGQDISMDILSKHLENAIQ ETPLRKYKGSLNSLIDMYQGKCDIVSLHLYDAETGQYNAPYVKRILTGEPFCLINVVL RKAGLYVQKGNPKNIQGWKDLKRADIRIINREKGSGARVLLDEQLGLLGVNPADVVGY GDIVTDHYAAASQVSSGQADAGIGAQHAAHMGSVDFIPLIDEQYDIVVLKKNEQLLKA VKEILNSEDYKANLSHLNGYETKLTGKVILET*" /label="yvgK CDS" gene complement(2918673..2919599) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /label="yvgK gene" downshifts complement(2918685) /Source="Nicolas_upshifts" /id="D1729" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="0.15268" /MaxDrop="6.72558" /score="21.9965704" /energy="-10.5" /TU="NA" /idTUdmin="U2617" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2919611..2919630) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2919632) /Source="Nicolas_upshifts" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2919646..2919649) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2919668..2919687 /Source="Nicolas_upshift_promotors" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2919677 /Source="Nicolas_upshifts" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="upshifts" CDS 2919710..2920492 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9302996; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molybdate-binding lipoprotein" /protein_id="NP_391218.1" /db_xref="EnsemblGenomes-Gn:BSU33380" /db_xref="EnsemblGenomes-Tr:CAB15343" /db_xref="GOA:O32208" /db_xref="InterPro:IPR005950" /db_xref="SubtiList:BG14094" /db_xref="UniProtKB/Swiss-Prot:O32208" /translation="MFKKYSIFIAALTAFLLVAGCSSNQSSTDSEKKVTLTISAAASA QDALEEIQKNYEKDHQHITIQDNYGSSGALQKQISQGAGADLFFSAAEDKFKKLVDDG DIAKKDSTELVGNEIVLVVPKNGDSPVTSFSNLAESEKIALGTPESVPAGAYGKESLT KLSLWDKVKDKIVYGKDVRQVLSYVETGNVDAGVVYKTDALVSKKVNIVDEAKADTHS PIVYPLGIVKDTKHRKEAKEFYEYLQSDEAMKVFEKYGFTAE*" /label="modA CDS" gene 2919710..2920492 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /label="modA gene" CDS 2920464..2921156 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="molybdenum transport permease" /protein_id="NP_391219.3" /db_xref="EnsemblGenomes-Gn:BSU33390" /db_xref="EnsemblGenomes-Tr:CAB15344" /db_xref="GOA:O32209" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011867" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14095" /db_xref="UniProtKB/Swiss-Prot:O32209" /translation="MRNMALLPSSISASEFFTPVVLSFQVAAVAGIVVIILGTLAGAW MSRASFFGKTALETCFMLPLVLPPTVVGFILIVIFGKHSFIGQAIEWIFQQPVIFTWW AAVIASAVVAFPLMYQSAKTGFADIDPDIQGAAMVDGASRWKVFIHISVPLAYPSLLT GSILSLARALGEFGATLMFAGNIPGVTQTLPTAIYVALDSGNNTLAWAWVVCIVVISF LMLFFIQQKKTH*" /label="modB CDS" gene 2920464..2921156 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /label="modB gene" downshifts 2921148 /Source="Nicolas_upshifts" /id="D1730" /incds=0 /nref=40 /ntot=195 /MaxReadThrough="0.43895" /MaxDrop="4.92503" /score="19.0609965" /energy="-9.4" /TU="NA" /idTUdmin="U2618" /TUdmin=9 /isTUend="TRUE" /label="downshifts" CDS complement(2921187..2922017) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /EC_number="1.1.1.283" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544192, 16232966, 17114254, 19585557" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544192, 16232966, 17114254, 19585557; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous glyoxal/methylglyoxal reductase" /protein_id="NP_391220.1" /db_xref="EnsemblGenomes-Gn:BSU33400" /db_xref="EnsemblGenomes-Tr:CAB15345" /db_xref="GOA:O32210" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3D3F" /db_xref="PDB:3F7J" /db_xref="SubtiList:BG14096" /db_xref="UniProtKB/Swiss-Prot:O32210" /translation="MPTSLKDTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNG YRSIDTAAIYKNEEGVGIGIKESGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQ LDYLDLYLIHWPGKDKYKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPM VNQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQLLDNEVLTQIAEKHNKSVAQVI LRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDERVGPNPDELLF *" /label="pgoN CDS" gene complement(2921187..2922017) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /label="pgoN gene" downshifts complement(2921193) /Source="Nicolas_upshifts" /id="D1731" /incds=0 /nref=190 /ntot=269 /MaxReadThrough="4.7445" /MaxDrop="7.9269" /score="27.8070829" /energy="-9.7" /TU="U2620" /idTUdmin="U2620" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2921880..2921884 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2921900..2921904 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2921909 /Source="Nicolas_upshifts" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2922019 /Source="Nicolas_upshifts" /id="D1732" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="0.95687" /MaxDrop="4.12116" /score="31.5807071" /energy="-11.6" /TU="NA" /idTUdmin="U2618" /TUdmin=880 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2922047..2922066) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2922065) /Source="Nicolas_upshifts" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2922081..2922088) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2922173..2922179 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2922193 /Source="Nicolas_upshifts" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2922194..2922212 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2922240..2922725 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 22307285, 25217289; Product type f: factor" /codon_start=1 /transl_table=11 /product="exported stress induced factor" /protein_id="NP_391221.1" /db_xref="EnsemblGenomes-Gn:BSU33410" /db_xref="EnsemblGenomes-Tr:CAB15346" /db_xref="SubtiList:BG14097" /db_xref="UniProtKB/Swiss-Prot:O32211" /translation="MKRIRIPMTLALGAALTIAPLSFASAEENPAPKMSQTTTAGTTA ADVGLNVNLDVLGIANQIADAIKSAQNRDGFVKNLMESSFYASGQKYNVMVFNLSQEY EDHLNGVQFYGSAVYDGITYGIWVFEDGTFTNKGDGGWINWAFRGWFDRDGSTVAFHR P*" /label="yvgO CDS" gene 2922240..2922725 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /label="yvgO gene" downshifts 2922724 /Source="Nicolas_upshifts" /id="D1733" /incds=0 /nref=18 /ntot=93 /MaxReadThrough="3.44281" /MaxDrop="6.83046" /score="31.5807071" /energy="-11.6" /TU="U2621" /idTUdmin="U2621" /TUdmin="-571" /isTUend="FALSE" /label="downshifts" CDS complement(2922769..2924781) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16021482, 16850406, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16021482, 16850406, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_391222.1" /db_xref="EnsemblGenomes-Gn:BSU33420" /db_xref="EnsemblGenomes-Tr:CAB15347" /db_xref="GOA:O32212" /db_xref="InterPro:IPR004705" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR018422" /db_xref="SubtiList:BG14098" /db_xref="UniProtKB/Swiss-Prot:O32212" /translation="MDIFLVVLVLLTIIAISNIVNRFIPFIPVPLIQVALGILAASFP QGLHFELNTELFFVLFIAPLLFNDGKRTPRAELWNLRAPILLLALGLVFATVIVGGYT IHWMIPAIPLAAAFGLAAILSPTDVVAVSALSGRVKMPKGILRLLEGEGLMNDASGLV AFKFAIAAAVTGAFSLAQAAVSFVFISLGGLLCGVVISFLIIRFRLFLRRLGMQDVTM HMLIQILTPFVIYLAAEEIGVSGILAVVAGGITHAVEQDRLESTMIKLQIVSSSTWNI ILFILNGLVFVILGTQIPDVISVIFNDTAISNMKVIGYILVITFTLMLLRFLWVLFFW NGKWFFNKDQNIYKPGLRSTLLISISGVRGAVTLAGSFSIPYFLEDGTPFPERNLILF LAAGVILCTLVIATVVLPILTEKEEEDEERNKKLLTARRKLIKTALQTIKEDMNETNK TASLAVIAEYNEKMKNLRFQQYTSSNRIKKHERKVRAQGVKAEQEALMKMLERGDIPE ETANVLQERFNELEILYANPFKVGLSKTRLKRLMYWIFFGEHKKPEMSILNEAGLIRA TRVKTAKAAIEYLEKHKTDEHKEVFLSVITFYKQLIFRLEHSHHELKSSAHFENQKLE VKLKAVQAIRNEIQTLFEEREISRDISHELRQYINDVEAAMLEGGE*" /label="nhaK CDS" gene complement(2922769..2924781) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /label="nhaK gene" downshifts complement(2922777) /Source="Nicolas_upshifts" /id="D1734" /incds=0 /nref=118 /ntot=238 /MaxReadThrough="2.66359" /MaxDrop="5.82216" /score="41.6492295" /energy="-13.2" /TU="NA" /idTUdmin="U2622" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(2924447..2924451) /Source="Nicolas_upshift_promotors" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2924449) /Source="Nicolas_upshifts" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2924782..2924933) /Source="Nicolas_S_feature" /locus_tag="new_3430344_3430495_c" /HighExp="dia5, T0.30H, T-0.40H, Salt, Diami, T1.0H, T0.0H, T1.30H, dia15, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.746, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1281" misc_feature complement(2924910..2924928) /Source="Nicolas_upshift_promotors" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2924933) /Source="Nicolas_upshifts" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2925036..2926751) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (hemoprotein beta-subunit)" /protein_id="NP_391223.1" /db_xref="EnsemblGenomes-Gn:BSU33430" /db_xref="EnsemblGenomes-Tr:CAB15348" /db_xref="GOA:O32213" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR011786" /db_xref="InterPro:IPR036136" /db_xref="SubtiList:BG14099" /db_xref="UniProtKB/Swiss-Prot:O32213" /translation="MVTKILKAPDGSPSDVERIKKESDYLRGTLKEVMLDRISAGIPD DDNRLMKHHGSYLQDDRDLRNERQKQKLEPAYQFMLRVRMPGGVSTPEQWLVMDDLSQ KYGNGTLKLTTRETFQMHGILKWNMKKTIQTIHSALLDTIAACGDVNRNVMCASNPYQ SEIHSEVYEWSKKLSDDLLPRTRAYHEIWLDEERVAGTPEEEVEPMYGPLYLPRKFKI GIAVPPSNDIDVFSQDLGFIAIVEDGKLIGFNVAIGGGMGMTHGDTATYPQLAKVIGF CRPEQMYDVAEKTITIQRDYGNRSVRKNARFKYTVDRLGLENVKEELENRLGWSLEEA KPYHFDHNGDRYGWVEGIEDKWHFTLFVEGGRITDYDDYKLMTGLREIAKVHTGEFRL TANQNLMIANVSSDKKEEISALIEQYGLTDGKHYSALRRSSMACVALPTCGLAMAEAE RYLPTLLDKIEEIIDENGLRDQEITIRMTGCPNGCARHALGEIGFIGKAPGKYNMYLG AAFDGSRLSKMYRENIGEADILSELRILLSRYAKEREEGEHFGDFVIRAGIIKATTDG TNFHD*" /label="cysI CDS" gene complement(2925036..2926751) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /label="cysI gene" downshifts complement(2925043) /Source="Nicolas_upshifts" /id="D1735" /incds=0 /nref=211 /ntot=254 /MaxReadThrough="3.28258" /MaxDrop="6.31358" /score="23.5256972" /energy="-13.8" /TU="U2624" /idTUdmin="U2624" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" CDS complement(2926777..2928594) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (flavoprotein alpha-subunit)" /protein_id="NP_391224.1" /db_xref="EnsemblGenomes-Gn:BSU33440" /db_xref="EnsemblGenomes-Tr:CAB15349" /db_xref="GOA:O32214" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010199" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14100" /db_xref="UniProtKB/Swiss-Prot:O32214" /translation="MQLQVMNSPFNQEQAELLNRLLPTLTESQKIWLSGYLSAQSVSA QEAAGTPAAAVSAEAPAPAVSKEVTVLYGSQTGNAQGLAENAGKQLEQSGFQVTVSSM SDFKPNQLKKVTNLLIVVSTHGEGEPPDNALSFHEFLHGRRAPKLEDLRFSVLALGDS SYEFFCQTGKEFDQRLEELGGKRISPRVDCDLDYDEPAAEWLEGVLKGLNEAGGGSAA PAPAAASQTGESSYSRTNPFRAEVLENLNLNGRGSNKETRHVELSLEGSGLTYEPGDS LGVYPENDPELVELLLKEMNWDPEEIVTLNKQGDVRPLKEALISHYEITVLTKPLLEQ AAQLTGNDELRELLAPGNEENVKAYIEGRDLLDLVRDYGPFSVSAQEFVSILRKMPAR LYSIASSLSANPDEVHLTIGAVRYDAHGRERKGVCSILCAERLQPGDTLPVYVQHNQN FKLPKDPETPIIMVGPGTGVAPFRSFMQEREETGAEGKAWMFFGDQHFVTDFLYQTEW QNWLKDGVLTKMDVAFSRDTEEKVYVQHRMLEHSAELFEWLQEGAAVYICGDEKHMAH DVHNTLLEIIEKEGNMSREEAEAYLADMQQQKRYQRDVY*" /label="cysJ CDS" gene complement(2926777..2928594) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /label="cysJ gene" promotor_-10 complement(2928636..2928655) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2928645..2928652 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2928655) /Source="Nicolas_upshifts" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" upshifts 2928658 /Source="Nicolas_upshifts" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2928665..2928684 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2928668..2928675) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2928765..2931089) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544244, 24520113" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544244, 24520113; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription factor" /protein_id="NP_391225.1" /db_xref="EnsemblGenomes-Gn:BSU33450" /db_xref="EnsemblGenomes-Tr:CAB15350" /db_xref="GOA:O32215" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="SubtiList:BG14101" /db_xref="UniProtKB/Swiss-Prot:O32215" /translation="MNQQDKEWKEEQSRIDEVLKELEKKERFLETSAGGLKHDIIGLR KSFWEDVKVNFDDAHEAIETMASIKQQAELLSDREHNHRRMDQQLKRIHQLKKSPYFG RIDFIENGEEQAERIYIGLASCLDEKEEHFLIYDWRAPISSLYYNYSPGKAEYEVPGE TIEGEMVLKRQFMIKNGTLKAMFNTDMTIGDEMLQEVLSHHSDTQMKNIVSTIQKEQN QIIRNEKSKILIVQGAAGSGKTSAALQRVAYLLYRHRGVIDAGQIVLFSPNFLFNSYV SSVLPELGEENMEQATFQEYIEHRLGRKFKCESPFDQLEYCLTETKGGDFPTRLAGIT WKAGLSFQQFINEYVTRLSSEGMIFKNIIFRGQKLITKEQIQSYFYSLDQNHSIPNRM EQTAKWLLSELNKLEKKERRKDWVVHEAELLDKEDYLDVYKKLQERKRFSESTFNDYQ REQQLLAAIIVKKAFKPLKQAVRLLAFLDVTQLYLQLFSGWGGKFQHEKMDAIGELTR SAFTDNKLLYEDAAPFLYMQDLIEGRKKNTKIKHLFIDEAQDYSPFQMAYMRSIFPAA SMTVLGDINQSIYAHTINGDQRMDACFEDEPAEYVRLKRTYRSTRQIVEFTKAMLQDG ADIEPFNRSGEMPLVVKTEGHESLCQKLAQEIGRLKKKGHETIAVICKTAHQCIQAHA HMSEYTDVRLIHKENQPFQKGVCVIPVYLAKGIEFDAVLVYDASEEHYHTEHDRRLLY TACTRAMHMLAVFYTGEASPFVTAVPPHLYQIAE*" /label="helD CDS" gene complement(2928765..2931089) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /label="helD gene" downshifts complement(2928783) /Source="Nicolas_upshifts" /id="D1736" /incds=0 /nref=26 /ntot=168 /MaxReadThrough="1.20405" /MaxDrop="4.59044" /score="18.6044234" /energy="-8.5" /TU="NA" /idTUdmin="U2628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2931109..2931116 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2931131..2931150 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(2931132..2931147) /Source="Nicolas_upshift_promotors" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2931135 /Source="Nicolas_upshifts" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2931137) /Source="Nicolas_upshifts" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2931182..2931201) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2931191) /Source="Nicolas_upshifts" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2931217..2931223) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2931227..2931246) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2931247) /Source="Nicolas_upshifts" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2931260..2931268) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2931274) /Source="Nicolas_upshifts" /id="D1737" /incds=0 /nref=19 /ntot=158 /MaxReadThrough="2.30604" /MaxDrop="4.26839" /score="16.6103553" /energy="-9.2" /TU="NA" /idTUdmin="U2630" /TUdmin=17 /isTUend="TRUE" /label="downshifts" CDS complement(2931287..2931895) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391226.1" /db_xref="EnsemblGenomes-Gn:BSU33460" /db_xref="EnsemblGenomes-Tr:CAB15351" /db_xref="GOA:O32216" /db_xref="InterPro:IPR005115" /db_xref="SubtiList:BG14102" /db_xref="UniProtKB/Swiss-Prot:O32216" /translation="MAWELLSVIGIIAFAVSGAIVAMEEEYDILGVYILGIVTAFGGG AIRNLLIGVPVSALWEQGAYFQIALLSITIVFLFPKLLLKHWNKWGNLSDAIGLAAFA IQGALYAVKMGHPLSAVIVAAVLTGSGGGIIRDLLAGRKPLVLKAEIYAVWAALGGLI VGLGWLGNSFGLYVLFFVLVVCRVCSYMFNWKLPNRSFRLDN*" /label="yvgT CDS" gene complement(2931287..2931895) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /label="yvgT gene" promotor_-10 complement(2931934..2931953) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2931951) /Source="Nicolas_upshifts" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2931969..2931973) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2932082..2932498) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391227.1" /db_xref="EnsemblGenomes-Gn:BSU33470" /db_xref="EnsemblGenomes-Tr:CAB15352" /db_xref="GOA:O32217" /db_xref="InterPro:IPR003752" /db_xref="InterPro:IPR012187" /db_xref="InterPro:IPR023380" /db_xref="SubtiList:BG14103" /db_xref="UniProtKB/Swiss-Prot:O32217" /translation="MKNRIVFLYASWVVALIAMLGSLYFSEIRKFIPCELCWYQRILM YPLVLILGIATFQGDTRVKKYVLPMAIIGAFISIMHYLEQKVPGFSGIKPCVSGVPCS GQYINWFGFITIPFLALIAFILIIIFMCLLKGEKSE*" /label="bdbC CDS" gene complement(2932082..2932498) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /label="bdbC gene" downshifts complement(2932092) /Source="Nicolas_upshifts" /id="D1738" /incds=0 /nref=120 /ntot=264 /MaxReadThrough="1.31968" /MaxDrop="6.21723" /score="26.5991603" /energy="-12.7" /TU="NA" /idTUdmin="U2631" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2932503..2933171) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11744713, 11872755, 12637552, 15661011, 17501922, 19535335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11744713, 11872755, 12637552, 15661011, 17501922, 19535335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391228.1" /db_xref="EnsemblGenomes-Gn:BSU33480" /db_xref="EnsemblGenomes-Tr:CAB15353" /db_xref="GOA:O32218" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:3EU3" /db_xref="PDB:3EU4" /db_xref="PDB:3GH9" /db_xref="PDB:3GHA" /db_xref="SubtiList:BG14104" /db_xref="UniProtKB/Swiss-Prot:O32218" /translation="MKKKQQSSAKFAVILTVVVVVLLAAIVIINNKTEQGNDAVSGQP SIKGQPVLGKDDAPVTVVEFGDYKCPSCKVFNSDIFPKIQKDFIDKGDVKFSFVNVMF HGKGSRLAALASEEVWKEDPDSFWDFHEKLFEKQPDTEQEWVTPGLLGDLAKSTTKIK PETLKENLDKETFASQVEKDSDLNQKMNIQATPTIYVNDKVIKNFADYDEIKETIEKE LKGK*" /label="bdbD CDS" gene complement(2932503..2933171) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /label="bdbD gene" promotor_-10 complement(2933223..2933242) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2933238) /Source="Nicolas_upshifts" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2933249) /Source="Nicolas_upshifts" /id="D1739" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="7.34296" /MaxDrop="3.6233" /score="12.4442247" /energy="-11.3" /TU="U2632" /idTUdmin="U2633" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2933256..2933261) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2933291..2935399) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /EC_number="3.6.3.3" /EC_number="3.6.3.5" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Cd(II), Zn(II) and Co(II) exporter (ATPase)" /protein_id="NP_391229.3" /db_xref="EnsemblGenomes-Gn:BSU33490" /db_xref="EnsemblGenomes-Tr:CAB15354" /db_xref="GOA:O32219" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14105" /db_xref="UniProtKB/Swiss-Prot:O32219" /translation="MRLVKQEYVLDGLDCSNCARKIENGVKGIKGINGCAVNFAASTL TVSADGKEEQWVTNKVEKKVKSIDPHVTVRQKHIKKSADDGYRNRMVNMLIRMAAAVI LGAAAYLVQSGTIEFFLFLGAYLIIGGDIIIRAVKNIIRGQVFDEHFLMALATIGAFL IQQYPEGVAVMLFYQIGELFQGAAVSRSRKSISALMDIRPDYANLKTKNGIEQVSSED VQTGDIIVVNPGESIPLDGKVVQGSAMVDTSALTGESVPRKAAEGQDVMSGFINQNGV LHIEVTKGYQESAVSKILDLVQNASSRKARTENFITKFAKYYTPAVVIIAVLLAFVPP LVLSGAALSDWVYRALIFLVISCPCALVVSIPLGFFGGIGAASKAGVLVKGSNYLEAL NQVKYAVFDKTGTLTKGSFEVTEIKPAEGFTKDRLLEAAAYAELHSQHPIAESVRKAY GKMLSSDEIESYEEISGHGIFAKVNGTEILAGNKKLMEREQIEDVPDENAGTIVHVAV DQRYAGAIIIADEIKEDAAQAVADLKSLGIKQTAMLTGDSKQTGEAVGKQLGIGEVYA ELLPQDKVAQVEALEAKLLPSEKLIFVGDGINDTPVLARADIGVAMGGLGSDAAVEAA DIVLMTDQPSKIAEAIRIAKRTRRIVWQNIGFALGVKAIFLILGAFGIATMWEAVFSD VGVTLLAVANAMRVMRLKNK*" /label="cadA CDS" gene complement(2933291..2935399) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /label="cadA gene" S_feature complement(2935391..2935492) /Source="Nicolas_S_feature" /locus_tag="new_3440953_3441054_c" /HighExp="dia5, LBGtran, LBGstat, Diami, LBGexp, Gly, Lbtran, T0.30H, M40t45, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 0.999" /TUlongSig="SigB" /TUlongPSig="0.587" /label="S1282" promotor_-10 complement(2935486..2935505) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2935492) /Source="Nicolas_upshifts" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2935521..2935528) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2935559..2937967) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /EC_number="3.6.3.54" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper transporter ATPase" /protein_id="NP_391230.2" /db_xref="EnsemblGenomes-Gn:BSU33500" /db_xref="EnsemblGenomes-Tr:CAB15355" /db_xref="GOA:O32220" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="PDB:1JWW" /db_xref="PDB:1KQK" /db_xref="PDB:1OPZ" /db_xref="PDB:1OQ3" /db_xref="PDB:1OQ6" /db_xref="PDB:1P6T" /db_xref="PDB:2RML" /db_xref="PDB:2VOY" /db_xref="SubtiList:BG14106" /db_xref="UniProtKB/Swiss-Prot:O32220" /translation="MSEQKEIAMQVSGMTCAACAARIEKGLKRMPGVTDANVNLATET SNVIYDPAETGTAAIQEKIEKLGYHVVTEKAEFDIEGMTCAACANRIEKRLNKIEGVA NAPVNFALETVTVEYNPKEASVSDLKEAVDKLGYKLKLKGEQDSEAAAKKKEERKQTA RLIFSAVLSFPLLWAMVSHFTFTSFIWVPDIFLNPWMQFALATPVQFLIGWPFYVGAY KALRNKSANMDVLVALGTTAAYAYSLYLTFQSIGSHGHTDGLYYETSAILLTLILLGK LFETKAKGRSSDAIKKLMKLQAKTATVVRDGQEQIIPIDEVLVNDIVYVKPGERIPVD GEVVEGRSAVDESMITGESLPVDKNPGDSVTGSTVNANGFLKIKAVNVGKDTALSHII KIVEEAQGSKAPIQRLADQISGIFVPIVLGIAVLTFLIWYLWAAPGDFAEAISKFIAV LVIACPCALGLATPTSIMAGSGRAAEFGILFKGGEHLEKTHRLDTIVLDKTGTVTNGK PRLTDAIPFGRFEEKDLLQFAAAAETGSEHPLGEAIIAGVKDKGLEIPKLTRFEAKVG AGILAEAGGKSILVGTRKLMESEQVEHGALLAQMEELEAEGKTVMLVSIDGEAAGLVA VADTIKDTSRKAVARLKELGLDVIMMTGDNRRTAEAIAKEAGIANIIAEVLPEQKAAE IARLQKEGRQTAMVGDGINDAPALATADIGMAIGTGTDIAMETADITLIRGDLNSIAD AIRMSRLTMKNIKQNLFWALGYNSLGIPIAALGFLAPWIAGAAMAFSSVSVVLNALRL QKVK*" /label="copA CDS" gene complement(2935559..2937967) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /label="copA gene" downshifts complement(2935581) /Source="Nicolas_upshifts" /id="D1740" /incds=0 /nref=15 /ntot=68 /MaxReadThrough="5.02116" /MaxDrop="3.63756" /score="26.9828242" /energy="-7.9" /TU="U2633" /idTUdmin="U2635" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2935647) /Source="Nicolas_upshifts" /id="D1741" /incds=1 /nref=52 /ntot=227 /MaxReadThrough="5.93949" /MaxDrop="4.28993" /score="26.9828242" /energy="-7.9" /TU="U2633,U2635" /idTUdmin="U2635" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2937968..2938050) /Source="Nicolas_S_feature" /locus_tag="new_3443530_3443612_c" /HighExp="Diami, dia5, dia15, Gly, T0.30H, Heat, T1.0H, T1.30H, T0.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.999, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S1283" CDS complement(2938051..2938260) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344; Product type f: factor" /codon_start=1 /transl_table=11 /product="copper insertion chaperone and transporter component" /protein_id="NP_391231.1" /db_xref="EnsemblGenomes-Gn:BSU33510" /db_xref="EnsemblGenomes-Tr:CAB15356" /db_xref="GOA:O32221" /db_xref="InterPro:IPR000428" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR036163" /db_xref="PDB:1K0V" /db_xref="PDB:1P8G" /db_xref="PDB:2QIF" /db_xref="PDB:3I9Z" /db_xref="SubtiList:BG14107" /db_xref="UniProtKB/Swiss-Prot:O32221" /translation="MEQKTLQVEGMSCQHCVKAVETSVGELDGVSAVHVNLEAGKVDV SFDADKVSVKDIADAIEDQGYDVAK*" /label="copZ CDS" gene complement(2938051..2938260) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /label="copZ gene" promotor_-10 complement(2938284..2938303) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-10" upshifts complement(2938305) /Source="Nicolas_upshifts" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="upshifts" promotor_-35 complement(2938316..2938322) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-35" CDS complement(2938334..2938639) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17143269, 18048925, 22904286, 24831014, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17143269, 18048925, 22904286, 24831014, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of copper utilisation proteins-Cu(I)" /protein_id="NP_391232.1" /db_xref="EnsemblGenomes-Gn:BSU33520" /db_xref="EnsemblGenomes-Tr:CAB15357" /db_xref="GOA:O32222" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG14108" /db_xref="UniProtKB/Swiss-Prot:O32222" /translation="MEKHNEHKTLNHKSSKEKDQITNRLKRIEGQVRGIQNMVENDRY CVDILVQISAVQAAMKNVALHLLEDHAHHCVADAIKSGDGEQAISELLDVFKKFTKS* " /label="csoR CDS" gene complement(2938334..2938639) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /label="csoR gene" misc_feature 2938603..2938622 /Source="Nicolas_upshift_promotors" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2938614 /Source="Nicolas_upshifts" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2938653..2938672) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-10" upshifts complement(2938679) /Source="Nicolas_upshifts" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="upshifts" promotor_-35 complement(2938686..2938692) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-35" promotor_-35 2938731..2938737 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2938752..2938770 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2938760 /Source="Nicolas_upshifts" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2938767..2939843 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /EC_number="1.1.1.371" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15937154, 20133360, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 20133360, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NADP(+)-dependent)" /protein_id="NP_391233.1" /db_xref="EnsemblGenomes-Gn:BSU33530" /db_xref="EnsemblGenomes-Tr:CAB15358" /db_xref="GOA:O32223" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="PDB:3GDO" /db_xref="PDB:3GFG" /db_xref="SubtiList:BG14057" /db_xref="UniProtKB/Swiss-Prot:O32223" /translation="MITLLKGRRKVDTIKVGILGYGLSGSVFHGPLLDVLDEYQISKI MTSRTEEVKRDFPDAEVVHELEEITNDPAIELVIVTTPSGLHYEHTMACIQAGKHVVM EKPMTATAEEGETLKRAADEKGVLLSVYHNRRWDNDFLTIKKLISEGSLEDINTYQVS YNRYRPEVQARWREKEGTATGTLYDLGSHIIDQTLHLFGMPKAVTANVMAQRENAETV DYFHLTLDYGKLQAILYGGSIVPANGPRYQIHGKDSSFIKYGIDGQEDALRAGRKPED DSWGADVPEFYGKLTTIRGSDKKTETIPSVNGSYLTYYRKIAESIREGAALPVTAEEG INVIRIIEAAMESSKEKRTIMLEH*" /label="iolW CDS" gene 2938767..2939843 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /label="iolW gene" downshifts 2939830 /Source="Nicolas_upshifts" /id="D1742" /incds=0 /nref=155 /ntot=248 /MaxReadThrough="2.17322" /MaxDrop="6.48885" /score="-5.36701412" /energy="-19.4" /TU="NA" /idTUdmin="U2636" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2939880..2940515) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17284825, 17725564, 18208493" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17284825, 17725564, 18208493; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:dichloroindophenol oxidoreductase (2-methylhydroquinone resistance)" /protein_id="NP_391234.1" /db_xref="EnsemblGenomes-Gn:BSU33540" /db_xref="EnsemblGenomes-Tr:CAB15359" /db_xref="GOA:O32224" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14058" /db_xref="UniProtKB/Swiss-Prot:O32224" /translation="MAKVLYITAHPHDEATSYSMATGKAFIESYKEANPNDEVVHIDL YKENIPHIDADVFSGWGKLQSGTGFEELSESEKAKVGRLGELSDQFASADKYVFVTPL WNFSFPPVMKAYLDSVAVAGKSFKYTEQGPVGLLTDKKAIHIQARGGYYSEGPAAEME MGHRYIGIMMNFFGVPSFDGIFVEGHNAEPDKAQQIKEDAIARAKEAGKTF*" /label="azoRB CDS" gene complement(2939880..2940515) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /label="azoRB gene" downshifts complement(2939893) /Source="Nicolas_upshifts" /id="D1743" /incds=0 /nref=211 /ntot=263 /MaxReadThrough="1.58189" /MaxDrop="6.89477" /score="31.0885268" /energy="-15.4" /TU="NA" /idTUdmin="U2637" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2940516..2940613) /Source="Nicolas_S_feature" /locus_tag="new_3446078_3446175_c" /HighExp="Heat, UNK1, G/S, Salt, HiTm, GM-0.1, MG 25, SMM, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1284" promotor_-10 complement(2940593..2940612) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2940613) /Source="Nicolas_upshifts" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2940626..2940632) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2940675..2942570) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12107147, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391235.1" /db_xref="EnsemblGenomes-Gn:BSU33550" /db_xref="EnsemblGenomes-Tr:CAB15360" /db_xref="GOA:O32225" /db_xref="SubtiList:BG14059" /db_xref="UniProtKB/Swiss-Prot:O32225" /translation="MNKTAANNQRIMPIVKDAFRIHANPFPWKKAIGSGFASGFPVLV GALAGHTDYGLIASIGGFVYLYAGGESYKKRALKLLLVSIGIALSFGLGTLLSGMLWM MAAVLGLIGAAAMFIFSALGIQGPAPMFFVLAFLVSSGLPADPSQALFRAGLTFLGGI FAMGIALIGWLWNKHGPEGAVLQKTYHQLAACLSAVGTPGFHNAQHQTVLMLRTARQT VLGKGNRRKKSRHDERFFRLLEKADDIFIAIIHFSAETPDRETAQIEKALRQTGDMLA NARVFNTFQINENESEPRRKLFEEINEVLYIASGRFDKQLDGEPSRLPSSFYFLRNAF DWKSPVLIRALKYGIVLFAADMFALAFGFARSYWIPLSAAAVMLGTTVVFTLHRAIQR SAGTVIGVILAGAILFFKPGGVYIAFCIAALQCLLEMLIVRNYALAVPFLTANALVIT ESMHGGAGAGYFMIARLTDVAVGSVIGLLGTMLLWRRFSTKRLPELVRNVIRLEGQFM EKLLTGQIADEHKLRVSLVRLRDAYDKALGEFPHANADALWPAISGAQHLGYYLLSAQ AHRRPSAPFSDEEINQLRAFFEQAEQSFIMKRMPADIQVPHVPHYPRISKELSALYSG LRTAFEK*" /label="yvaC CDS" gene complement(2940675..2942570) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /label="yvaC gene" promotor_-10 complement(2942621..2942632) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2942621) /Source="Nicolas_upshifts" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2942647..2942653) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2942720) /Source="Nicolas_upshifts" /id="D1744" /incds=0 /nref=20 /ntot=155 /MaxReadThrough="2.49984" /MaxDrop="4.21522" /score="11.4033831" /energy="-8" /TU="NA" /idTUdmin="U2639" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(2942733..2943134) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391236.1" /db_xref="EnsemblGenomes-Gn:BSU33560" /db_xref="EnsemblGenomes-Tr:CAB15361" /db_xref="GOA:O32226" /db_xref="InterPro:IPR020348" /db_xref="SubtiList:BG14060" /db_xref="UniProtKB/Swiss-Prot:O32226" /translation="MRYMKLFFLVTDIGFILYWLSAGFSLIPESWAFKHHDHPFMIAW NWSFFPLDILISVTGLYSLYLQRVNRADWKLMALISLVLTCCSGLQALSFWTFSSDFD LVWWLFNGYLLIYPLFFIHLLLKEGRRTKQS*" /label="yvaD CDS" gene complement(2942733..2943134) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /label="yvaD gene" CDS complement(2943131..2943490) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948170, 15849754, 16850406, 19549332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite-efflux transporter" /protein_id="NP_391237.1" /db_xref="EnsemblGenomes-Gn:BSU33570" /db_xref="EnsemblGenomes-Tr:CAB15362" /db_xref="GOA:O32227" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG14061" /db_xref="UniProtKB/Swiss-Prot:O32227" /translation="MNWVFLCLAILFEVAGTVSMKLSSGFTKLIPSLLLIFFYGGSLF FLTLTLKSIDVSVAYAVWSGMGIVLITVVGFLFFQEHVSVMKVISIGLIIAGVVSLNL IEHVAVSEPVHKSGQYK*" /label="yvaE CDS" gene complement(2943131..2943490) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /label="yvaE gene" CDS complement(2943487..2944059) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391238.1" /db_xref="EnsemblGenomes-Gn:BSU33580" /db_xref="EnsemblGenomes-Tr:CAB15363" /db_xref="GOA:O32228" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14062" /db_xref="UniProtKB/Swiss-Prot:O32228" /translation="MDKRILAETFRLIKQKGFSFTMNDLAAALGTSKRTLYAYYSSKD QLVEAVVEQFIAEMKQIERDIYENESLNVLEKVKQMLISLPQGMELLNMGLLNELKKY HYDAWLTLDAFIKEEWAIVLALLNECKQQKRIRNINPDLFVHMYIGSINQVYDPEYPL KHQFTTGEVLESIVDVLFNGITADEEADAT*" /label="yvaF CDS" gene complement(2943487..2944059) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /label="yvaF gene" promotor_-10 complement(2944097..2944116) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2944102) /Source="Nicolas_upshifts" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2944130..2944137) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2944170..2944964) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391239.1" /db_xref="EnsemblGenomes-Gn:BSU33590" /db_xref="EnsemblGenomes-Tr:CAB15364" /db_xref="GOA:O32229" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14063" /db_xref="UniProtKB/Swiss-Prot:O32229" /translation="MKLNLQGKTALVTGSTSGIGKAIASSLAEEGAAVIINGRREEKV NQTIDELKTQHAEAVLYPAAFDLGTEEGCNELFQAYPEVDILVNNLGIFEPAEYFDIP DDEWFRFFEVNIMSGVRLTRRYLHNMIEKKEGRVIFIASEAAIMPSQEMAHYSATKTM QLSISRSLAELATGTNVTVNTVMPGSTLTEGVETMLNSLYPGENLTVQEAEARFMKEN RPTSIIQRLIRPEEIAHFVTFLSSPLSSAINGAALRADGGLVRSVF*" /label="yvaG CDS" gene complement(2944170..2944964) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /label="yvaG gene" promotor_-10 complement(2944985..2945003) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2944997) /Source="Nicolas_upshifts" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2945018..2945024) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2945030..2945049) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2945041) /Source="Nicolas_upshifts" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2945043..2945108) /Source="Nicolas_S_feature" /locus_tag="new_3450605_3450670_c" /HighExp="H2O2, Heat, Diami, G180, Paraq, dia15, Oxctl, BMM, G135, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.47, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="0.996, 1" /label="S1285" promotor_-35 complement(2945063..2945070) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2945150..2945509) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /product="transfer-messenger RNA (tmRNA, 10Sa RNA)" /experiment="publication(s) with functional evidences, PMID:11395451, 11918677, 14766921, 17369301, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11918677, 14766921, 17369301, 18673456" /label="ssrA RNA" gene complement(2945150..2945509) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /label="ssrA gene" downshifts complement(2945153) /Source="Nicolas_upshifts" /id="D1745" /incds=0 /nref=260 /ntot=272 /MaxReadThrough="4.32959" /MaxDrop="9.81359" /score="26.7868133" /energy="-15.8" /TU="U2642,U2644" /idTUdmin="U2643" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2945493..2945501) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2945503) /Source="Nicolas_upshifts" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2945516..2945521) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2945561..2945580) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2945569) /Source="Nicolas_upshifts" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2945571..2945635) /Source="Nicolas_S_feature" /locus_tag="new_3451133_3451197_c" /HighExp="Etha, C90, dia5, dia15, Diami, T0.0H, T-0.40H, T-1.40H, LPhT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.997, 0.996, 1" /TUlongSig="SigB, SigA" /TUlongPSig="0.999, 0.753" /label="S1286" promotor_-35 complement(2945593..2945597) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2945635) /Source="Nicolas_upshifts" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="upshifts" promotor_-10 complement(2945636..2945655) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-10" promotor_-35 complement(2945670..2945677) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-35" CDS complement(2945686..2946156) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10947848, 11395451, 11918677, 12682299, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10947848, 11395451, 11918677, 12682299, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="tmRNA-binding protein" /protein_id="NP_391240.1" /db_xref="EnsemblGenomes-Gn:BSU33600" /db_xref="EnsemblGenomes-Tr:CAB15365" /db_xref="GOA:O32230" /db_xref="InterPro:IPR000037" /db_xref="InterPro:IPR020081" /db_xref="InterPro:IPR023620" /db_xref="SubtiList:BG14064" /db_xref="UniProtKB/Swiss-Prot:O32230" /translation="MPKGSGKVLSQNKKANHDYFIEETYETGIVLQGTEIKSIRAGRV NLKDSFAKIERGEVFLHNMHVSPYEQGNRYNHDPLRTRKLLMHRKEINKLIGLTKEKG YSLVPLKLYLKNGFAKVLLGLGKGKKNYDKREDLKRKDAKREIERAFRDSQKGF*" /label="smpB CDS" gene complement(2945686..2946156) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /label="smpB gene" promotor_no_box 2945983..2946083 /Source="Nicolas_upshift_promotors" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2946043 /Source="Nicolas_upshifts" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2946153 /Source="Nicolas_upshifts" /id="D1746" /incds=0 /nref=2 /ntot=105 /MaxReadThrough="0.62459" /MaxDrop="3.18501" /score="-9.3042809" /energy="-3.3" /TU="NA" /idTUdmin="U2647" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2946201..2946220) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(2946207) /Source="Nicolas_upshifts" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" S_feature complement(2946209..2946300) /Source="Nicolas_S_feature" /locus_tag="new_3451771_3451862_c" /HighExp="Etha, S8, Cold, S7, G135, G180, G150, H2O2, M9-stat, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig="0.753" /label="S1287" promotor_-35 complement(2946236..2946239) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" CDS complement(2946301..2948640) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /EC_number="3.1.13.1" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 19215769, 22333191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 19215769, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease R" /protein_id="NP_391241.1" /db_xref="EnsemblGenomes-Gn:BSU33610" /db_xref="EnsemblGenomes-Tr:CAB15366" /db_xref="GOA:O32231" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004476" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR011805" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013223" /db_xref="InterPro:IPR022966" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14065" /db_xref="UniProtKB/Swiss-Prot:O32231" /translation="MEKEAFMEKLLSFMKEEAYKPLTVQELEEMLNITEAEEFKELVK ALVALEEKGLIVRTRSDRYGIPEKMNLIKGKISAHAKGFAFLLPEDTSLSDVFIPPNE LNTAMNGDIVMVRLNSQSSGSRQEGTVIRILERAIQRVVGTYTETRNFGFVIPDDKKI TSDIFIPKNGKNGAAEGHKVVVKLTSYPEGRMNAEGEVETILGHKNDPGIDILSVIHK HGLPGEFPADAMEQASSTPDTIDEKDLKDRRDLRDQVIVTIDGADAKDLDDAVTVTKL DDGSYKLGVHIADVSHYVTENSPIDKEALERGTSVYLVDRVIPMIPHRLSNGICSLNP KVDRLTLSCEMTINSQGQVTEHEIFQSVIKTTERMTYSDVNKILVDDDEELKQKYEPL VPMFKDMERLAQILRDKRMDRGAVDFDFKEAKVLVDDEGAVKDVVIRERSVAEKLIEE FMLVANETVAEHFHWMNVPFIYRIHEEPNAEKLQKFLEFVTTFGYVVKGTAGNIHPRA LQSILDAVRDRPEETVISTVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPIRRYPDL IVHRLIRTYLINGKVDEATQEKWAERLPDIAEHTSSMERRAVDAERETDDLKKAEYML DKIGEEFDGMISSVTNFGMFVELPNTIEGLVHVSFMTDDYYRFDEQHFAMIGERTGNV FRIGDEITVKVVDVNKDERNIDFEIVGMKGTPRRPRELDSSRSRKRGKPARKRVQSTN TPVSPAPSEEKGEWFTKPKKKKKKRGFQNAPKQKRKKKK*" /label="rnr CDS" gene complement(2946301..2948640) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /label="rnr gene" promotor_-35 2947401..2947404 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2947420..2947423 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2947429 /Source="Nicolas_upshifts" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2948659..2949399) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1369099, 17369301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase" /protein_id="NP_391242.2" /db_xref="EnsemblGenomes-Gn:BSU33620" /db_xref="EnsemblGenomes-Tr:CAB15367" /db_xref="GOA:O32232" /db_xref="InterPro:IPR012354" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14066" /db_xref="UniProtKB/Swiss-Prot:O32232" /translation="MKVVTPKPFTFKGGDKAVLLLHGFTGNTADVRMLGRYLNERGYT CHAPQYEGHGVPPEELVHTGPEDWWKNVMDGYEYLKSEGYESIAACGLSLGGVFSLKL GYTVPIKGIVPMCAPMHIKSEEVMYQGVLSYARNYKKFEGKSPEQIEEEMKEFEKTPM NTLKALQDLIADVRNNVDMIYSPTFVVQARHDHMINTESANIIYNEVETDDKQLKWYE ESGHVITLDKERDLVHQDVYEFLEKLDW*" /label="estA CDS" gene complement(2948659..2949399) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /label="estA gene" promotor_-10 complement(2949055..2949073) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-10" upshifts complement(2949067) /Source="Nicolas_upshifts" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="upshifts" promotor_-35 complement(2949088..2949094) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-35" misc_feature complement(2949427..2949445) /Source="Nicolas_upshift_promotors" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2949441) /Source="Nicolas_upshifts" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="upshifts" downshifts complement(2949529) /Source="Nicolas_upshifts" /id="D1747" /incds=0 /nref=30 /ntot=212 /MaxReadThrough="6.16751" /MaxDrop="5.2246" /score="-4.14736839" /energy="-9.1" /TU="U2650" /idTUdmin="U2649" /TUdmin="-3234" /isTUend="FALSE" /label="downshifts" CDS complement(2949531..2949761) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10074070, 10644701, 16243836" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074070, 10644701, 16243836; Product type f: factor" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_391243.1" /db_xref="EnsemblGenomes-Gn:BSU33630" /db_xref="EnsemblGenomes-Tr:CAB15368" /db_xref="GOA:O32233" /db_xref="InterPro:IPR004692" /db_xref="SubtiList:BG14067" /db_xref="UniProtKB/Swiss-Prot:O32233" /translation="MHAVLITLLVIVSIALIIVVLLQSSKSAGLSGAISGGAEQLFGK QKARGLDLILHRITVVLAVLFFVLTIALAYIL*" /label="secG CDS" gene complement(2949531..2949761) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /label="secG gene" promotor_-10 complement(2949791..2949810) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(2949812) /Source="Nicolas_upshifts" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" promotor_-35 complement(2949825..2949828) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" promotor_-35 2949850..2949856 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2949870..2949881 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2949871 /Source="Nicolas_upshifts" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="upshifts" CDS 2949910..2950680 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391244.1" /db_xref="EnsemblGenomes-Gn:BSU33640" /db_xref="EnsemblGenomes-Tr:CAB15369" /db_xref="GOA:O32234" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14068" /db_xref="UniProtKB/Swiss-Prot:O32234" /translation="MPLISIDSRKHLFYEEYGQGIPIIFIHPPGMGRKVFYYQRLLSK HFRVIFPDLSGHGDSDHIDQPASISYYANEIAQFMDALHIDKAVLFGYSAGGLIAQHI GFTRPDKVSHLILSGAYPAVHNVIGQKLHKLGMYLLEKNPGLLMKILAGSHTKDRQLR SILTDHMKKADQAHWHQYYLDSLGYNCIEQLPRLEMPMLFMYGGLRDWTFTNAGYYRR SCRHAEFFRLEYQGHQLPTKQWKTCNELVTGFVLTHHS*" /label="yvaM CDS" gene 2949910..2950680 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /label="yvaM gene" promotor_-35 2949932..2949940 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2949951..2949969 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2949981 /Source="Nicolas_upshifts" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2950720..2950953) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional regulator" /protein_id="NP_391245.1" /db_xref="EnsemblGenomes-Gn:BSU33650" /db_xref="EnsemblGenomes-Tr:CAB15370" /db_xref="GOA:O32235" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG14159" /db_xref="UniProtKB/Swiss-Prot:O32235" /translation="MPVEKIQIRRDYVLQYMVNNDYSLNQLALEIGVSPATLSRVLNG ERRPGQLVIGKMLHYFNLKFEDLFYYDFVDKSQ*" /label="yvzC CDS" gene complement(2950720..2950953) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /label="yvzC gene" promotor_-35 2951044..2951051 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-35" upshifts 2951059 /Source="Nicolas_upshifts" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="upshifts" promotor_-10 2951063..2951082 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-10" CDS 2951105..2951512 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_391246.1" /db_xref="EnsemblGenomes-Gn:BSU33660" /db_xref="EnsemblGenomes-Tr:CAB15371" /db_xref="GOA:O32236" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14069" /db_xref="UniProtKB/Swiss-Prot:O32236" /translation="MESFGEQLRALREERKLTVNQLATYSGVSAAGISRIENGKRGVP KPATIKKLAEALKIPYEGLMYKAGYIEEVHEARAPYETKCKLLEKAEAYDLKNLALLE NEKWQYLNKEDLLMLDHYFSFISDEAKKRSADD*" /label="rghRA CDS" gene 2951105..2951512 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /label="rghRA gene" CDS 2951542..2951961 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional repressor" /protein_id="NP_391247.1" /db_xref="EnsemblGenomes-Gn:BSU33670" /db_xref="EnsemblGenomes-Tr:CAB15372" /db_xref="GOA:O32237" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14070" /db_xref="UniProtKB/Swiss-Prot:O32237" /translation="MSPFGQQLRELRRARKLTVNQLAVYSGISSATISKIENGKRGTP KPATIKKLAAVLKVPYENLMAAAGHIQAFPEEIREASEGYQSVYEIYQTAVTRGAEHL PIFNSQKWEHLSKQDIENLSKYFDFLSSEAKKRASSS*" /label="rghRB CDS" gene 2951542..2951961 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /label="rghRB gene" promotor_-35 2951999..2952006 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2952020..2952039 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2952027 /Source="Nicolas_upshifts" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 2952053..2952379 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20639328; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catechol dioxygenase" /protein_id="NP_391248.2" /db_xref="EnsemblGenomes-Gn:BSU33680" /db_xref="EnsemblGenomes-Tr:CAB15373" /db_xref="GOA:O32238" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14071" /db_xref="UniProtKB/Swiss-Prot:O32238" /translation="MNQSEMCPRFEKAVDILSKRWVALIVFQLLNGSQRFSEIEAALP NLSGRVLSERLKELELEGVVKRDVIPETPVRIEYSLTDKGKALAPILGEISKWATEWI DPSFLD*" /label="catR CDS" gene 2952053..2952379 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /label="catR gene" S_feature 2952380..2952464 /Source="Nicolas_S_feature" /locus_tag="new_3457942_3458026" /HighExp="Cold, H2O2, Diami, LBGstat, LPhT, dia15, G180, Paraq, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.985" /label="S1288" promotor_-35 2952435..2952442 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2952455..2952473 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2952466 /Source="Nicolas_upshifts" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 2952504..2954204 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8188684, 11872722, 27899502; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative methyl-accepting transducer" /protein_id="NP_391249.1" /db_xref="EnsemblGenomes-Gn:BSU33690" /db_xref="EnsemblGenomes-Tr:CAB15374" /db_xref="GOA:O32239" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR024478" /db_xref="InterPro:IPR035440" /db_xref="SubtiList:BG14072" /db_xref="UniProtKB/Swiss-Prot:O32239" /translation="MRLTISRKFSLVFLTLILINLLVGGIGVLNMQHIIQKTDEINTK WIDGIKGITSINYVTEHLSSKEKDFLIYTDKSKMDTLDQEMNQIMEDINQKLDNYEKT ISTDKEQKLFEQLQTKVNTYMDIHAQIIESGRTNDMDKARGLLVQTEASFEDMKKTIT QLVDLNQEGSNTAVKETKAVYHKGLIYTALLVAASILISIFIWLYITRNIVKPIIRMK ESANHIAEGDLSNDMEALNSKDELGDLNEALQKMVGNLRDIVGYSKDISSRVLSSSQV LATATNETRSGSKHITETMNEMAEGSEQQAQDAVTIAESMNEFTESIDKAYNHGITIS DTSQNVLELAVSGNENMATSLQQMKTIHHIVEEAVHKVRSLEQHSQDINKLVQVINGI AEQTNLLSLNAAIEAARAGESGKGFAVVAEEVRKLADGVSDSVQDITRIVNGTQQEIH TVITYLESSFTEVEKGTENLTDTGQAMQHIKQSVTHVADSIKEVTDGLKQLTNQSITI NQSIENIASVSEESAAGIEETFSITEQSAHSMDQVLLNAEELEQLANELNEKMGQFTI *" /label="yvaQ CDS" gene 2952504..2954204 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /label="yvaQ gene" S_feature complement(2953220..2954213) /Source="Nicolas_S_feature" /locus_tag="new_3458782_3459775_c" /HighExp="S6, S5, S7, C30, S8, S4, S3, LoTm, BT, B36" /AntisenseName="yvaQ" /AntisenseCor="-0.38660715434937498" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1289" downshifts 2954182 /Source="Nicolas_upshifts" /id="D1748" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="1.43789" /MaxDrop="3.86744" /score="26.1532813" /energy="-12.2" /TU="NA" /idTUdmin="U2655" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2954244..2954924) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391250.1" /db_xref="EnsemblGenomes-Gn:BSU33700" /db_xref="EnsemblGenomes-Tr:CAB15375" /db_xref="GOA:P39775" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12636" /db_xref="UniProtKB/Swiss-Prot:P39775" /translation="MNVLEQLMTYYAQNGSYVMDEFGRHFLMSAYGVLFAAVVGVPAG ILIAHFRRLSAWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDMIVRGSNATNGTAIILAGAIPTAVMAVGADLLMAWLERALSPVKKKRTG AKHVQSAA*" /label="opuBD CDS" gene complement(2954244..2954924) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /label="opuBD gene" downshifts complement(2954258) /Source="Nicolas_upshifts" /id="D1749" /incds=0 /nref=119 /ntot=171 /MaxReadThrough="3.12805" /MaxDrop="5.39624" /score="35.0134287" /energy="-12.2" /TU="NA" /idTUdmin="U2657" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2954618..2954624 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2954639..2954657 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2954644..2957395 /Source="Nicolas_S_feature" /locus_tag="new_3460206_3462957" /HighExp="Sw, M9-stat, B60, Salt, LoTm, T0.30H, BC, Gly, B36, T1.0H" /AntisenseName="opuBC" /AntisenseCor="-0.13125567572652899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1290" upshifts 2954644 /Source="Nicolas_upshifts" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2954941..2955861) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (choline-binding lipoprotein)" /protein_id="NP_391251.1" /db_xref="EnsemblGenomes-Gn:BSU33710" /db_xref="EnsemblGenomes-Tr:CAB15376" /db_xref="GOA:Q45462" /db_xref="InterPro:IPR007210" /db_xref="PDB:3R6U" /db_xref="SubtiList:BG12635" /db_xref="UniProtKB/Swiss-Prot:Q45462" /translation="MKRKYLKLMIGLALAATLTLSGCSLPGLSAAADQTIKIGAQSMS ESEIIASMLGQLIEHHTDLKTTTIKNLGSNAVQQQALMNGEIDIAATRYTGDALTGTL RMEPEKDPDKALALTQREFKKRYDLKWYDSYGFDNTYAFTVSKELADQYHLETVSDVK KWAPQLKLGVDNYWMKLKGNGYQDFTKTYGMTFGGTYPMQIGLVYDAVKSGKMDIVLA YSTDGRIKSYGLKMLKDDKQFFPPYDCSPVVPEKVLKEHPELEGIIKKMLGKIDTATM QELNYEVDGNLKEPSVVAKEYLEKHRYFES*" /label="opuBC CDS" gene complement(2954941..2955861) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /label="opuBC gene" CDS complement(2955873..2956526) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391252.1" /db_xref="EnsemblGenomes-Gn:BSU33720" /db_xref="EnsemblGenomes-Tr:CAB15377" /db_xref="GOA:Q45461" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12634" /db_xref="UniProtKB/Swiss-Prot:Q45461" /translation="MHHIVQFLQTNGGELLYKTYEHITISLIAVILGVLVAVPLGVVL TRMKKGAGTIIGIVNIIQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIRGVNKNLLESGKGIGMTPAEQVRLVELPLAAPVIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIVIDYVLAVAERKLTPAGMQRLKELS* " /label="opuBB CDS" gene complement(2955873..2956526) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /label="opuBB gene" CDS complement(2956543..2957688) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 18321243, 21658392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 18321243, 21658392; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (ATP-binding protein)" /protein_id="NP_391253.1" /db_xref="EnsemblGenomes-Gn:BSU33730" /db_xref="EnsemblGenomes-Tr:CAB15378" /db_xref="GOA:Q45460" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12633" /db_xref="UniProtKB/Swiss-Prot:Q45460" /translation="MLTLENVSKTYKGGKKAVNNVNLKIAKGEFICFIGPSGCGKTTT MKMINRLIEPSAGKIFIDGENIMDQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEQQRKERARELLKLVDMGPEYVDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQKTLHKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDDILRNPADEFVEEFIGKERLIQSSSPDVERVDQIMNTQPVTITADKTLSEAIQLM RQERVDSLLVVNDERVLQGYVDVEIIDQCRKKANLVSEVLHEDIYTVLGGTLLRDTVR KILKRGVKYVPVVDEDRRLIGIVTRASLVDIVYDSLWGEEKQLAALS*" /label="opuBA CDS" gene complement(2956543..2957688) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /label="opuBA gene" S_feature complement(2957689..2957756) /Source="Nicolas_S_feature" /locus_tag="new_3463251_3463318_c" /HighExp="T5.0H, T3.30H, T3.0H, T-5.40H, T4.0H, T-0.40H, T-1.40H, T2.30H, T-3.40H, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1291" upshifts complement(2957756) /Source="Nicolas_upshifts" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2957757..2957776) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2957787..2957791 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2957791..2957794) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2957807..2957825 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2957812 /Source="Nicolas_upshifts" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2957907..2957911 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2957927..2957946 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2957930 /Source="Nicolas_upshifts" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" CDS 2957972..2958505 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (controlling choline uptake)" /protein_id="NP_391254.2" /db_xref="EnsemblGenomes-Gn:BSU33740" /db_xref="EnsemblGenomes-Tr:CAB15379" /db_xref="GOA:C0SPB8" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14073" /db_xref="UniProtKB/Swiss-Prot:C0SPB8" /translation="MEKDPLTIIEQAEDHFIERIAENMHAFGMPSTVGRVLGIIYMNR KPMTLTELSEATGMSKTRMSQVVREMLDANIAEKVFEKGVRKDLYEVEQDYYQTFITL FSATWSKVVSKNKMMHKKLNRELLSVLDEELTPEAEEKVNELLKELKEWLDYYNWLSR LIEFFESEDIFKYVPKP*" /label="yvaV CDS" gene 2957972..2958505 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /label="yvaV gene" S_feature complement(2958172..>2958571) /Source="Nicolas_S_feature" /locus_tag="new_3463734_3464253_c" /HighExp="S8, Cold, C30, GM 25, GM 60, BC, T-4.40H, M/G, GM-0.1, MG 120" /AntisenseName="yvaV" /AntisenseCor="-7.6123637680436104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.503, 1, 0.758" /TUlongSig="NA" /TUlongPSig="NA" /label="S1292" downshifts 2958494 /Source="Nicolas_upshifts" /id="D1750" /incds=0 /nref=51 /ntot=161 /MaxReadThrough="2.68472" /MaxDrop="4.69377" /score="-3.5823381" /energy="-8.6" /TU="NA" /idTUdmin="U2659" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(2958571,2958578) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs14" N_region 2958572..2958577 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs14" S_feature <2958578..2958653 /Source="Nicolas_S_feature" /locus_tag="new_3466412_3467550" /HighExp="Pyr, S8, nit, C30, GM 150, M9-stat, S7, S2, G/S, S1" /AntisenseName="sdpI" /AntisenseCor="-7.9710115369408502E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.636, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1297" S_feature complement(<2958578..2958644) /Source="Nicolas_S_feature" /locus_tag="new_3467393_3467541_c" /HighExp="Salt, B36, Gly, B60, LoTm, S8, GM 5, MG 25, Cold, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1298" CDS complement(2958649..2959338) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391260.1" /db_xref="EnsemblGenomes-Gn:BSU33800" /db_xref="EnsemblGenomes-Tr:CAB15385" /db_xref="GOA:O34742" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12640" /db_xref="UniProtKB/Swiss-Prot:O34742" /translation="MEVLQQLGTYYSQNGGYVLQEFYRHFLMSVYGVLFAAIVGIPLG ILIARYRRLSGWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDIIVRGSNATNGTAIILAGAIPTALMAVIADLVMGWLERALSPIKKKKGN FIIADRKTTSI*" /label="opuCD CDS" gene complement(2958649..2959338) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /label="opuCD gene" downshifts complement(2958689) /Source="Nicolas_upshifts" /id="D1757" /incds=0 /nref=95 /ntot=199 /MaxReadThrough="5.55394" /MaxDrop="6.7177" /score="8.72167152" /energy="-11.6" /TU="U2667" /idTUdmin="U2667" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" promotor_-35 2959281..2959289 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2959303..2959322 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2959317 /Source="Nicolas_upshifts" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2959356..2960267) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 28256787; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (osmoprotectant-binding lipoprotein)" /protein_id="NP_391261.1" /db_xref="EnsemblGenomes-Gn:BSU33810" /db_xref="EnsemblGenomes-Tr:CAB15386" /db_xref="GOA:O32243" /db_xref="InterPro:IPR007210" /db_xref="PDB:3PPN" /db_xref="PDB:3PPO" /db_xref="PDB:3PPP" /db_xref="PDB:3PPQ" /db_xref="PDB:3PPR" /db_xref="SubtiList:BG12639" /db_xref="UniProtKB/Swiss-Prot:O32243" /translation="MTKIKWLGAFALVFVMLLGGCSLPGLGGASDDTIKIGAQSMTES EIVANMIAQLIEHDTDLNTALVKNLGSNYVQHQAMLGGDIDISATRYSGTDLTSTLGK EAEKDPKKALNIVQNEFQKRFSYKWFDSYGFDNTYAFTVTKKFAEKEHINTVSDLKKN ASQYKLGVDNAWLKRKGDGYKGFVSTYGFEFGTTYPMQIGLVYDAVKNGKMDAVLAYS TDGRIKAYDLKILKDDKRFFPPYDCSPVIPEKVLKEHPELEGVINKLIGQIDTETMQE LNYEVDGKLKEPSVVAKEFLEKHHYFD*" /label="opuCC CDS" gene complement(2959356..2960267) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /label="opuCC gene" CDS complement(2960287..2960940) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391262.1" /db_xref="EnsemblGenomes-Gn:BSU33820" /db_xref="EnsemblGenomes-Tr:CAB15387" /db_xref="GOA:O34878" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12638" /db_xref="UniProtKB/Swiss-Prot:O34878" /translation="MNQMMTFLQTNGGELLYKTGEHLYISLIAVVLGIIVAVPLGVAL TRMKKGAGAVIGFVNIVQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIKGVNKNLLESGKGIGMTGWEQIRLVEIPLAIPIIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIIIDYVLAVTERKVTPKGLQGMKEVS* " /label="opuCB CDS" gene complement(2960287..2960940) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /label="opuCB gene" CDS complement(2960963..2962105) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10216873, 9925583, 21658392, 27378384, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216873, 9925583, 21658392, 27378384, 27683249; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (ATP-binding protein)" /protein_id="NP_391263.1" /db_xref="EnsemblGenomes-Gn:BSU33830" /db_xref="EnsemblGenomes-Tr:CAB15388" /db_xref="GOA:O34992" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12637" /db_xref="UniProtKB/Swiss-Prot:O34992" /translation="MLKLEQVSKVYKGGKKAVNSIDLDIAKGEFICFIGPSGCGKTTT MKMINRLIEPSSGRIFIDGENIMEQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEEKRKERARELLKLVDMGPEYLDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQRTLNKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDEILRNPANEFVEEFIGKERLIQSRPDIERVEQMMNRTPVTVSADKTLSQAIQLMR EKRVDSLLVVDRQNVLKGYVDVEMIDQNRKKASIVGDVYRSDIYTVQKGALLRDTVRK ILKQGIKYVPVVDEQNHLAGIVTRASLVDIVYDSIWGDEENQLMTI*" /label="opuCA CDS" gene complement(2960963..2962105) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /label="opuCA gene" promotor_-10 complement(2962149..2962168) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-10" upshifts complement(2962164) /Source="Nicolas_upshifts" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="upshifts" promotor_-35 complement(2962183..2962186) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-35" promotor_-35 2962302..2962309 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2962322..2962341 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2962333 /Source="Nicolas_upshifts" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="upshifts" CDS 2962369..2962926 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23960087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23960087; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative transcriptional regulator of choline uptake systems" /protein_id="NP_391264.1" /db_xref="EnsemblGenomes-Gn:BSU33840" /db_xref="EnsemblGenomes-Tr:CAB15389" /db_xref="GOA:O34709" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14079" /db_xref="UniProtKB/Swiss-Prot:O34709" /translation="MKKTALDIIEHAEEHLIEKIAENMHTFGMPSTVGRVLGIIYMNR KPMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVRKDLYDVEQDYYQTFISL FAANWTKVVSKNKVLYKKLNRELSDLLQRDGLTPEAEEKVNQLLNELKEWLHYYDWLS RLIEFFESEEVFRYVPKTKECSSLK*" /label="opcR CDS" gene 2962369..2962926 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /label="opcR gene" S_feature 2962927..2963691 /Source="Nicolas_S_feature" /locus_tag="new_3471824_3472588" /HighExp="HiOs, GM 5, GM 10, Salt, MG 15, MG 10, MG 25, T0.0H, T-2.40H, GM 45" /AntisenseName="yvbG" /AntisenseCor="-0.14921239095219299" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1299" CDS complement(2962944..2963579) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391265.1" /db_xref="EnsemblGenomes-Gn:BSU33850" /db_xref="EnsemblGenomes-Tr:CAB15390" /db_xref="GOA:O32244" /db_xref="InterPro:IPR002771" /db_xref="SubtiList:BG14080" /db_xref="UniProtKB/Swiss-Prot:O32244" /translation="MMFSFIVHVFISLFAVSNPIGNVPIFLTLTEGYTAAERKAIARK AAILSFFILAAFLVFGHLIFKLFDINIHALRVAGGIFIFGIAYNLLNAKESHVQSLHH DEHKESKEKADISVTPLSIPIIAGPGTIATVMSLSAGHSGIGHYAAVMIGIAAVIALT FLFFHYSAFISSKLGKTEMNVITRLMGLILAVVAVGMIGAGLKGMFPVLTS*" /label="yvbG CDS" gene complement(2962944..2963579) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /label="yvbG gene" downshifts complement(2962957) /Source="Nicolas_upshifts" /id="D1758" /incds=0 /nref=21 /ntot=50 /MaxReadThrough="2.02169" /MaxDrop="4.45088" /score="10.9231366" /energy="-16.4" /TU="NA" /idTUdmin="U2669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2963620..2963638) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2963626) /Source="Nicolas_upshifts" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2963654..2963660) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2963665..2963672 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2963684..2963703 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2963693 /Source="Nicolas_upshifts" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 2963729..2964343 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391266.1" /db_xref="EnsemblGenomes-Gn:BSU33860" /db_xref="EnsemblGenomes-Tr:CAB15391" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR021722" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG14081" /db_xref="UniProtKB/Swiss-Prot:O32245" /translation="MFKKIAADALGLSDIGKIIEPQDYDKTDADDYVMHEDNEKIYFL IKTKADEYCFTNLALIHVDGERATSSKRTLKRYPYSQYKISDVFLETAGKVDLDVEIK FKLGGEQFDIDVHKDQIEKLKDLYKALLRIAETTYENDILINQAEQSLDKAVTILHHT RPEHVNIETQYKELTEFGFTWLTSVRSQYHIKDFGDVFEKYINN*" /label="yvbH CDS" gene 2963729..2964343 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /label="yvbH gene" downshifts 2964329 /Source="Nicolas_upshifts" /id="D1759" /incds=0 /nref=110 /ntot=197 /MaxReadThrough="2.66824" /MaxDrop="5.86088" /score="-4.16829989" /energy="-7.9" /TU="U2670" /idTUdmin="U2668" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 2964397..2964400 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2964415..2964434 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2964423 /Source="Nicolas_upshifts" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 2964475..2965173 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391267.1" /db_xref="EnsemblGenomes-Gn:BSU33870" /db_xref="EnsemblGenomes-Tr:CAB15392" /db_xref="GOA:O32246" /db_xref="InterPro:IPR029038" /db_xref="SubtiList:BG14082" /db_xref="UniProtKB/Swiss-Prot:O32246" /translation="MYCPQCGHQTDGGNFCEKCGSPLPGQSGHQHAAQTGAAAKQAAK QFGSFVLSVLKRPYQECKATGGEQLISAIITMVLFSLLTPLMFYILFSDGPGSVSFTA IFLEPTIYFILFLFGLHACIFFALKIAGNQVSFKDSFSRFGAFLIPFTAILILALFFF LLHTDICFTILAVGLIGAFFAIPPAMLSSYQHSYKGKVDFIYSTIVIYLIICVTFQLI IEHYVKEIFRYMLF*" /label="yvbI CDS" gene 2964475..2965173 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /label="yvbI gene" downshifts 2965146 /Source="Nicolas_upshifts" /id="D1760" /incds=0 /nref=72 /ntot=203 /MaxReadThrough="1.50622" /MaxDrop="4.71846" /score="17.2112529" /energy="-17.2" /TU="U2671" /idTUdmin="U2671" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(2965209..2967026) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15155184" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391268.1" /db_xref="EnsemblGenomes-Gn:BSU33880" /db_xref="EnsemblGenomes-Tr:CAB15393" /db_xref="GOA:O32247" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR026870" /db_xref="SubtiList:BG14083" /db_xref="UniProtKB/Swiss-Prot:O32247" /translation="MLFCKNCGSQNNEGAKFCKQCGTPIGGGSKQANQETASTAETRQ APRKPIPKKTIILWSSIAAACVILFAAYKTGAYFTSKDRLVDKFEQAVNDGDQDQIAT LLTPVNDNLKLTKNNVKPFLTYLKDHPDKKDELFASLRDETAQKDIVYAEKDGKSLLV FDHYDLKVAPVYFEVSSNYKNTDLYVNKEEAGSVKKADQAQTLGPYIPGEYTVSAKLK NDVVDLVKKEDIQAIGDSSFRVDLSLEADDVTFSLANDIKSGKGDLLINGKSIHKDPF KSVTYGPLLTDGSMTASVEAEFPWGKTKTAGVPIDDKEMELTLIPDQDTQEQIMNTIV KTTKQYSKALSDGNTAQMTEASANWKAETKDTVDSMKSADSYLKDRYLETDFDLDTFA LSQKNDGTWQVSVTGKELHQSSSYNDYTKSEMTDDSPSYEYLLSYDKKQKKWIFEDAE STFESAGTNIKKIKNDKPETYTSAWAGSKNKGSESSASGDVTDEQVTLFMGSYLQSQA DAVNQNNFSLMEDSLEKGSSLYSDQQHLVSKLNKEGTTEDFNNYEVKSWSQNGSAITI KTYEEFYITKSGGSPKLRTYNWTYTGVVKNGRIYLTSIQ*" /label="yvbJ CDS" gene complement(2965209..2967026) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /label="yvbJ gene" downshifts complement(2965228) /Source="Nicolas_upshifts" /id="D1761" /incds=0 /nref=31 /ntot=189 /MaxReadThrough="2.6958" /MaxDrop="3.67366" /score="15.9345511" /energy="-17.2" /TU="NA" /idTUdmin="U2673" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(2965399) /Source="Nicolas_upshifts" /id="D1762" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="4.6758" /MaxDrop="2.2812" /score="15.9345511" /energy="-17.2" /TU="U2673" /idTUdmin="U2673" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" misc_feature complement(2967068..2967087) /Source="Nicolas_upshift_promotors" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 2967072..2967091 /Source="Nicolas_upshift_promotors" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2967077 /Source="Nicolas_upshifts" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2967081) /Source="Nicolas_upshifts" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2967146..2967613 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acyltransferase" /protein_id="NP_391269.1" /db_xref="EnsemblGenomes-Gn:BSU33890" /db_xref="EnsemblGenomes-Tr:CAB15394" /db_xref="GOA:O32248" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YVK" /db_xref="SubtiList:BG14084" /db_xref="UniProtKB/Swiss-Prot:O32248" /translation="MNMQKLRIELGEETNDELYDLLLLADPSKDIVDEYLERGECYTA WAGDELAGVYVLLKTRPQTVEIVNIAVKESLQKKGFGKQLVLDAIEKAKKLGADTIEI GTGNSSIHQLSLYQKCGFRIQAIDHDFFLRHYDEDIFENGIQCRDMVRLYLDL*" /label="yvbK CDS" gene 2967146..2967613 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /label="yvbK gene" downshifts 2967610 /Source="Nicolas_upshifts" /id="D1763" /incds=0 /nref=199 /ntot=250 /MaxReadThrough="1.84358" /MaxDrop="5.3321" /score="15.9040274" /energy="-13.3" /TU="U2672" /idTUdmin="U2672" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(2967658..2968950) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /EC_number="4.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enolase" /protein_id="NP_391270.1" /db_xref="EnsemblGenomes-Gn:BSU33900" /db_xref="EnsemblGenomes-Tr:CAB15395" /db_xref="GOA:P37869" /db_xref="InterPro:IPR000941" /db_xref="InterPro:IPR020809" /db_xref="InterPro:IPR020810" /db_xref="InterPro:IPR020811" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:4A3R" /db_xref="SubtiList:BG10899" /db_xref="UniProtKB/Swiss-Prot:P37869" /translation="MPYIVDVYAREVLDSRGNPTVEVEVYTETGAFGRALVPSGASTG EYEAVELRDGDKDRYLGKGVLTAVNNVNEIIAPELLGFDVTEQNAIDQLLIELDGTEN KGKLGANAILGVSMACARAAADFLQIPLYQYLGGFNSKTLPVPMMNIVNGGEHADNNV DIQEFMIMPVGAPNFREALRMGAQIFHSLKSVLSAKGLNTAVGDEGGFAPNLGSNEEA LQTIVEAIEKAGFKPGEEVKLAMDAASSEFYNKEDGKYHLSGEGVVKTSAEMVDWYEE LVSKYPIISIEDGLDENDWEGHKLLTERLGKKVQLVGDDLFVTNTKKLSEGIKNGVGN SILIKVNQIGTLTETFDAIEMAKRAGYTAVISHRSGETEDSTIADIAVATNAGQIKTG APSRTDRVAKYNQLLRIEDQLAETAQYHGINSFYNLNK*" /label="eno CDS" gene complement(2967658..2968950) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /label="eno gene" downshifts complement(2967668) /Source="Nicolas_upshifts" /id="D1764" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="2.21852" /MaxDrop="9.34136" /score="29.8674712" /energy="-15" /TU="NA" /idTUdmin="U2674" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2968980..2970515) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /EC_number="5.4.2.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9830105, 10869096, 12682299, 19193632, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9830105, 10869096, 12682299, 19193632, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate mutase" /protein_id="NP_391271.1" /db_xref="EnsemblGenomes-Gn:BSU33910" /db_xref="EnsemblGenomes-Tr:CAB15396" /db_xref="GOA:P39773" /db_xref="InterPro:IPR005995" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR011258" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR036646" /db_xref="SubtiList:BG10898" /db_xref="UniProtKB/Swiss-Prot:P39773" /translation="MSKKPAALIILDGFGLRNETVGNAVALAKKPNFDRYWNQYPHQT LTASGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFERNQTFLDAIS NAKENNKALHLFGLLSDGGVHSHINHLFALLKLAKKEGLTKVYIHGFLDGRDVGPQTA KTYINQLNDQIKEIGVGEIASISGRYYSMDRDKRWDRVEKAYRAMAYGEGPSYRSALD VVDDSYANGIYDEFVIPSVITKENGEPVAKIQDGDSVIFYNFRPDRAIQISNTFTNKD FRDFDRGENYPKNLYFVCLTHFSETVDGYVAFKPINLDNTVGEVLSQHGLKQLRIAET EKYPHVTFFMSGGREAEFPGEERILINSPKVATYDLKPEMSAYEVKDALVKEIEADKH DAIILNFANPDMVGHSGMVEPTIKAIEAVDECLGEVVDAILAKGGHAIITADHGNADI LITESGEPHTAHTTNPVPVIVTKEGITLREGGILGDLAPTLLDLLGVEKPKEMTGTSL IQK*" /label="pgm CDS" gene complement(2968980..2970515) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /label="pgm gene" CDS complement(2970508..2971269) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /EC_number="5.3.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8021172, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="triose phosphate isomerase" /protein_id="NP_391272.1" /db_xref="EnsemblGenomes-Gn:BSU33920" /db_xref="EnsemblGenomes-Tr:CAB15397" /db_xref="GOA:P27876" /db_xref="InterPro:IPR000652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020861" /db_xref="InterPro:IPR022896" /db_xref="InterPro:IPR035990" /db_xref="SubtiList:BG10897" /db_xref="UniProtKB/Swiss-Prot:P27876" /translation="MRKPIIAGNWKMNKTLGEAVSFVEEVKSSIPAADKAEAVVCAPA LFLEKLASAVKGTDLKVGAQNMHFEESGAFTGEISPVALKDLGVDYCVIGHSERREMF AETDETVNKKAHAAFKHGIVPIICVGETLEEREAGKTNDLVADQVKKGLAGLSEEQVA ASVIAYEPIWAIGTGKSSTAKDANDVCAHIRKTVAESFSQEAADKLRIQYGGSVKPAN IKEYMAESDIDGALVGGASLEPQSFVQLLEEGQYE*" /label="tpiA CDS" gene complement(2970508..2971269) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /label="tpiA gene" CDS complement(2971300..2972484) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /EC_number="2.7.2.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559176, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559176, 12682299, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate kinase" /protein_id="NP_391273.1" /db_xref="EnsemblGenomes-Gn:BSU33930" /db_xref="EnsemblGenomes-Tr:CAB15398" /db_xref="GOA:P40924" /db_xref="InterPro:IPR001576" /db_xref="InterPro:IPR015824" /db_xref="InterPro:IPR015911" /db_xref="InterPro:IPR036043" /db_xref="SubtiList:BG11062" /db_xref="UniProtKB/Swiss-Prot:P40924" /translation="MNKKTLKDIDVKGKVVFCRVDFNVPMKDGEVTDDTRIRAALPTI KHLADQGAKVLLASHLGRPKGEVVEELRLTPVAARLGELLGKEVKKADEAYGDAVKAQ ISEMKDGDVLVLENVRFYPGEEKNDPELAKAFAELADVYVNDAFGAAHRAHASTAGIA EHLPAVAGFLMEKELDVLGKAVSNPDRPFTAIIGGAKVKDKIGVIESLLDKVDNLIIG GGLAYTFVKALGYEVGKSLLEEDKIELAKSFMDRAKEKGVNFYMPEDVLVADDFSNDA NVKIVPISEIPSDLEAIDIGTKTRETYADVIKNSKLVVWNGPMGVFEIDLFAQGTKAV AEALAEAKDTYSVIGGGDSAAAVEKFGLADKMSHISTGGGASLEFMEGKELPGVAALN DK*" /label="pgk CDS" gene complement(2971300..2972484) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /label="pgk gene" S_feature complement(2972485..2972725) /Source="Nicolas_S_feature" /locus_tag="new_3481382_3481622_c" /HighExp="Lbstat, Lbtran, C90, LBGtran, LBGexp, G150, M40t45, LPhT, M0t45, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA, SigK" /TUshortPSig="0.979, 0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1300" upshifts complement(2972725) /Source="Nicolas_upshifts" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2972727..2972800) /Source="Nicolas_S_feature" /locus_tag="new_3481624_3481697_c" /HighExp="C90, LBGtran, Lbstat, LBGexp, Lbtran, G150, M40t45, Etha, ferm, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1301" promotor_-10 complement(2972739..2972758) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2972774..2972778) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2972801..2973808) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /EC_number="1.2.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NAD-dependent, glycolytic)" /protein_id="NP_391274.1" /db_xref="EnsemblGenomes-Gn:BSU33940" /db_xref="EnsemblGenomes-Tr:CAB15399" /db_xref="GOA:P09124" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10827" /db_xref="UniProtKB/Swiss-Prot:P09124" /translation="MAVKVGINGFGRIGRNVFRAALNNPEVEVVAVNDLTDANMLAHL LQYDSVHGKLDAEVSVDGNNLVVNGKTIEVSAERDPAKLSWGKQGVEIVVESTGFFTK RADAAKHLEAGAKKVIISAPANEEDITIVMGVNEDKYDAANHDVISNASCTTNCLAPF AKVLNDKFGIKRGMMTTVHSYTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVSL VLPELKGKLNGGAMRVPTPNVSLVDLVAELNQEVTAEEVNAALKEAAEGDLKGILGYS EEPLVSGDYNGNKNSSTIDALSTMVMEGSMVKVISWYDNESGYSNRVVDLAAYIAKKG L*" /label="gapA CDS" gene complement(2972801..2973808) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /label="gapA gene" promotor_-35 2973727..2973730 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2973747..2973749 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2973749 /Source="Nicolas_upshifts" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2973855..2974877) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489127, 12622823, 17142398, 17293407, 18052209, 18554327" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489127, 12622823, 17142398, 17293407, 18052209, 18554327; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of gapA" /protein_id="NP_391275.1" /db_xref="EnsemblGenomes-Gn:BSU33950" /db_xref="EnsemblGenomes-Tr:CAB15400" /db_xref="GOA:O32253" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OKG" /db_xref="PDB:3BXE" /db_xref="PDB:3BXF" /db_xref="PDB:3BXG" /db_xref="PDB:3BXH" /db_xref="SubtiList:BG14085" /db_xref="UniProtKB/Swiss-Prot:O32253" /translation="MNQLIQAQKKLLPDLLLVMQKRFEILQYIRLTEPIGRRSLSASL GISERVLRGEVQFLKEQNLVDIKTNGMTLTEEGYELLSVLEDTMKDVLGLTLLEKTLK ERLNLKDAIIVSGDSDQSPWVKKEMGRAAVACMKKRFSGKNIVAVTGGTTIEAVAEMM TPDSKNRELLFVPARGGLGEDVKNQANTICAHMAEKASGTYRLLFVPGQLSQGAYSSI IEEPSVKEVLNTIKSASMLVHGIGEAKTMAQRRNTPLEDLKKIDDNDAVTEAFGYYFN ADGEVVHKVHSVGMQLDDIDAIPDIIAVAGGSSKAEAIEAYFKKPRNTVLVTDEGAAK KLLRDE*" /label="cggR CDS" gene complement(2973855..2974877) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /label="cggR gene" upshifts complement(2973871) /Source="Nicolas_upshifts" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2973899..2973900) /Source="Nicolas_upshift_promotors" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2974878..2974989) /Source="Nicolas_S_feature" /locus_tag="new_3483775_3483886_c" /HighExp="LPhT, C90, LBGtran, Heat, BI, LBGexp, Lbstat, Sw, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1302" downshifts 2974915 /Source="Nicolas_upshifts" /id="D1765" /incds=0 /nref=3 /ntot=50 /MaxReadThrough="4.48989" /MaxDrop="5.24842" /score="-9.71393179" /energy="-11.8" /TU="NA" /idTUdmin="U2675" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2974970..2974989) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2974989) /Source="Nicolas_upshifts" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2974991..2975101) /Source="Nicolas_S_feature" /locus_tag="new_3483888_3483998_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, S3, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1303" promotor_-35 complement(2975003..2975010) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2975084..2975103) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-10" upshifts complement(2975099) /Source="Nicolas_upshifts" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="upshifts" promotor_-35 complement(2975116..2975125) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-35" CDS complement(2975175..2976569) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9620981, 10417639, 15849754, 16850406, 20693325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620981, 10417639, 15849754, 16850406, 20693325; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arabinose-related compounds permease" /protein_id="NP_391276.1" /db_xref="EnsemblGenomes-Gn:BSU33960" /db_xref="EnsemblGenomes-Tr:CAB15401" /db_xref="GOA:P96710" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11907" /db_xref="UniProtKB/Swiss-Prot:P96710" /translation="MKNTPTQLEPNVPVTRSHSMGFVILISCAAGLGGLLYGYDTAVI SGAIGFLKDLYSLSPFMEGLVISSIMIGGVVGVGISGFLSDRFGRRKILMTAALLFAI SAIVSALSQDVSTLIIARIIGGLGIGMGSSLSVTYITEAAPPAIRGSLSSLYQLFTIL GISATYFINLAVQRSGTYEWGVHTGWRWMLAYGMVPSVIFFLVLLVVPESPRWLAKAG KTNEALKILTRINGETVAKEELKNIENSLKIEQMGSLSQLFKPGLRKALVIGILLALF NQVIGMNAITYYGPEIFKMMGFGQNAGFVTTCIVGVVEVIFTVIAVLLIDKVGRKKLM SIGSAFMAIFMILIGTSFYFELTSGIMMIVLILGFVAAFCVSVGPITWIMISEIFPNH LRARAAGIATIFLWGANWAIGQFVPMMIDSFGLAYTFWIFAVINILCFLFVVTICPET KNKSLEEIEKLWIK*" /label="araE CDS" gene complement(2975175..2976569) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /label="araE gene" downshifts complement(2975189) /Source="Nicolas_upshifts" /id="D1766" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="1.15614" /MaxDrop="3.28809" /score="1.06999853" /energy="-14.6" /TU="NA" /idTUdmin="U2679" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2976668..2976687) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2976682) /Source="Nicolas_upshifts" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2976702..2976709) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2976709..2976716 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2976730..2976749 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2976736 /Source="Nicolas_upshifts" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="upshifts" CDS 2976773..2977861 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the ara regulon (LacI family)" /protein_id="NP_391277.2" /db_xref="EnsemblGenomes-Gn:BSU33970" /db_xref="EnsemblGenomes-Tr:CAB15402" /db_xref="GOA:P96711" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR033532" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3TB6" /db_xref="PDB:4EGY" /db_xref="PDB:4EGZ" /db_xref="PDB:4H0E" /db_xref="PDB:5D4R" /db_xref="PDB:5D4S" /db_xref="SubtiList:BG11913" /db_xref="UniProtKB/Swiss-Prot:P96711" /translation="MLPKYAQVKEEISSWINQGKILPDQKIPTENELMQQFGVSRHTI RKAIGDLVSQGLLYSVQGGGTFVASRSAKSALHSNKTIGVLTTYISDYIFPSIIRGIE SYLSEQGYSMLLTSTNNNPDNERRGLENLLSQHIDGLIVEPTKSALQTPNIGYYLNLE KNGIPFAMINASYAELAAPSFTLDDVKGGMMAAEHLLSLGHTHMMGIFKADDTQGVKR MNGFIQAHRERELFPSPDMIVTFTTEEKESKLLEKVKATLEKNSKHMPTAILCYNDEI ALKVIDMLREMDLKVPEDMSIVGYDDSHFAQISEVKLTSVKHPKSVLGKAAAKYVIDC LEHKKPKQEDVIFEPELIIRQSARKLNE*" /label="araR CDS" gene 2976773..2977861 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /label="araR gene" downshifts 2977841 /Source="Nicolas_upshifts" /id="D1767" /incds=0 /nref=202 /ntot=247 /MaxReadThrough="1.17419" /MaxDrop="4.76041" /score="20.2322165" /energy="-13.6" /TU="NA" /idTUdmin="U2680" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2977910..2978920) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_391278.1" /db_xref="EnsemblGenomes-Gn:BSU33980" /db_xref="EnsemblGenomes-Tr:CAB15403" /db_xref="GOA:O32254" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG14086" /db_xref="UniProtKB/Swiss-Prot:O32254" /translation="MSNNQRKDTLLSVLNLSPVVQGGTIAESFRNSMDLARRAEEWGY HRYWLAEHHNIEGVASSATAVLIGHIAGGTKKIRVGSGGIMLPNHSSLVIAEQFGTLE TLYPGRIDLGLGRAPGTDQLTARALRRNINSGEDFPEQLEELRNYFKPSGNVRNQVRA IPGEGIDVPIWLLGSSGFSARLAGELGLPFAFAAHFSPANTVPALELYRNSFTPSDVL DEPYAMVGVTIIAADTNEKAQHLATSHYQRFLDLVRGTPNQLKPPVEDMDQIWSPYEK AMVNEQLSSTIVGGPEEVKAKLEDFVKTTQADEIMVNSETFEHADRMRSFEIIADVWK NR*" /label="yvbT CDS" gene complement(2977910..2978920) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /label="yvbT gene" downshifts complement(2977917) /Source="Nicolas_upshifts" /id="D1768" /incds=0 /nref=200 /ntot=252 /MaxReadThrough="1.53983" /MaxDrop="7.63266" /score="27.2032847" /energy="-14.2" /TU="NA" /idTUdmin="U2681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2978921..2978998) /Source="Nicolas_S_feature" /locus_tag="new_3487818_3487895_c" /HighExp="dia5, dia15, Diami, H2O2, Salt, Paraq, G180, Etha, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1304" promotor_-10 complement(2978988..2979007) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2978998) /Source="Nicolas_upshifts" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2979021..2979028) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2979077..2979955) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391279.1" /db_xref="EnsemblGenomes-Gn:BSU33990" /db_xref="EnsemblGenomes-Tr:CAB15404" /db_xref="GOA:O32255" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14087" /db_xref="UniProtKB/Swiss-Prot:O32255" /translation="MTITQLKVFVKIAETGSFTKAGQALNMTQPAVSHAISAIEAELD VKLIIRDRRNGLMLTDTGKQILVHIREVLKGIEKVEQVAAAEKGLELGTIHIGTFSTA SAYFMPKLISEFKQKYPKLELVLHEGTVNEVKEWLHTRMIDVGILLYPTEEMEYIHLK KDKMAVVLRDDHPLASHSAITLKDLDHEPMIVCDGGYESPFIDMFRQAGATLHPAFTV YNINTSISMIREGLGLAILSEMSMSGMPLPEHVVTRELDPQVYRDVQLAVPSLKEASL AAKLFIEMAKELFGAE*" /label="yvbU CDS" gene complement(2979077..2979955) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /label="yvbU gene" promotor_-35 2979613..2979619 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2979634..2979645 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2979645 /Source="Nicolas_upshifts" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2979989..2979996 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2980002..2980021) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-10" upshifts complement(2980007) /Source="Nicolas_upshifts" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="upshifts" promotor_-10 2980010..2980029 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2980012 /Source="Nicolas_upshifts" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2980035..2980039) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-35" CDS 2980055..2980972 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10844694, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cysteine and O-acetylserine efflux permease" /protein_id="NP_391280.1" /db_xref="EnsemblGenomes-Gn:BSU34000" /db_xref="EnsemblGenomes-Tr:CAB15405" /db_xref="GOA:O32256" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG14088" /db_xref="UniProtKB/Swiss-Prot:O32256" /translation="MKQLPKTRTALLLAFLVIMWGVNWPLSKAALAYSPPLLFAGIRT LIGGLLLVIVALPRIHKLRLKETWPIYLVSALLNITLFYGLQTIGLNYLPAGLFSAIV FFQPVLMGVFSWLWLGESMFVMKVIGLILGFAGVAVISAAGFGGHISVIGVLLALGSA VSWALGTVYMKKTGSRVDSIWMVALQLTIGSVFLLISGFWTESFSAIQWTAPFITSLL FISVFVIALGWLVFFTLVGSGEASKVASYTFLIPLISIVASSIFLHEPLTLSLLAGLL LIVTSICLVNTKSKAQKAAAIGINEKAAQ*" /label="cyeB CDS" gene 2980055..2980972 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /label="cyeB gene" downshifts 2980961 /Source="Nicolas_upshifts" /id="D1769" /incds=0 /nref=6 /ntot=15 /MaxReadThrough="2.97475" /MaxDrop="3.548" /score="22.9557936" /energy="-19.2" /TU="NA" /idTUdmin="U2684" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2981013..2982356) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19258532, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative leucine permease" /protein_id="NP_391281.1" /db_xref="EnsemblGenomes-Gn:BSU34010" /db_xref="EnsemblGenomes-Tr:CAB15406" /db_xref="GOA:O32257" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG14089" /db_xref="UniProtKB/Swiss-Prot:O32257" /translation="MKNDNQTLKRTMTSRHIMMMALGGAIGAGLFKGSSSAIDVAGPS VIIAYLLGGIILLFIMQGLAEMAVRNRNARTFRDLVQQVLGNYAAYFLDWIYWKMWVL NIAAEAVVAAIFIQYWLPGCPIWVLALGISLIVTIVNLLSVKIFAETEYWLAMIKITV IIIFIILGLLLLFVSFGDHTASGFSNLTDHGGFFPHGGTGLITAMLVVIYSYGGTEII GVTLAETKNPEKVVPKAVRSTLTRIVAFYLLPFFIIVSLIPWNQVNSVPESPFVMVFK MVGIPGADHIMNAVILLAIISSMNSGLYGSSRILYTQASDGRLPKVFSKLSSKNVPMF AILMCTSSLYIGVLISLFAGSQTFNYLMGSLGYTVLFIWLIIGFAHLKSRKQQTETPA YYVKWFPYTTWFAIVALLAILIGVIMTTSIVITGITAAIYLLITVAYLVKGRKHQ*" /label="yvbW CDS" gene complement(2981013..2982356) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /label="yvbW gene" misc_RNA complement(2982425..2982660) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /product="T-box riboswitch controlling synthesis of an amino acid transporter" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 18625071, 19258532; Product type n: RNA" /function="16.3: Control" /label="tboX RNA" gene complement(2982425..2982660) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /label="tboX gene" downshifts complement(2982559) /Source="Nicolas_upshifts" /id="D1770" /incds=1 /nref=1 /ntot=104 /MaxReadThrough="5.18182" /MaxDrop="2.29735" /score="33.4262209" /energy="-24.4" /TU="U2685,U2689" /idTUdmin="U2689" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2982661..2982757) /Source="Nicolas_S_feature" /locus_tag="new_3491558_3491654_c" /HighExp="Cold, GM 120, C30, GM 90, C90, GM 15, GM 10, GM 25, HPh, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1305" CDS complement(2982758..2983792) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12177332; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative epimerase modification of peptidoglycan" /protein_id="NP_391282.1" /db_xref="EnsemblGenomes-Gn:BSU34020" /db_xref="EnsemblGenomes-Tr:CAB15407" /db_xref="GOA:O32258" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG14090" /db_xref="UniProtKB/Swiss-Prot:O32258" /translation="MKKWLIIAVSLAIAIVLFMYTKGEAKAAGMTVGYTTGDTASYNS LTKYHTYMNAIATDTFAFEKNGQIIGDAPTKQLTYAKKKKIKTWAVISNYNDAIYDFD GDLASRVMSNKTAKKRFTDQLITLAKKHSYYGINIDFEAVNPEDRAAYSNFIQYVSQA LNKKHIKTMVSVPAKSADDKNDDWSWPYDYAKIGKYADFVQVMTYDEHGIWGEPGSVA STNWIKSSLQFSVKKIKANKVIMGIPAYGYDWDVKDGSTSTIREWNELKSLIKKQKAK PAFNKKSGSMTFSYVDKKKHKHVVWYENEKTVQTKSHLAKQYKIAGVSVYALGNESES FWKAIRKGTK*" /label="yvbX CDS" gene complement(2982758..2983792) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /label="yvbX gene" promotor_-10 complement(2983814..2983832) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2983820) /Source="Nicolas_upshifts" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2983845..2983852) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2983900..2984622) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22427629, 24196425, 24274019" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22427629, 24196425, 24274019; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase for L-lactate utilization" /protein_id="NP_391283.1" /db_xref="EnsemblGenomes-Gn:BSU34030" /db_xref="EnsemblGenomes-Tr:CAB15408" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR022823" /db_xref="SubtiList:BG14091" /db_xref="UniProtKB/Swiss-Prot:O32259" /translation="MTKGTIQNQESFLNRIASSLGRERRTGGVAVPEWAHQPQYKTLE GYSADDLVTVLKNHCVKIHTELIETDSTGLYDALREQVSRFSGGPVIIPKDPRFEEYG LKSLLTKDWPSEGTPVWEWDADKGEENIKKAEQANVGITFSEITLAESGTVVLFSSKD IGRSVSLLPTTYIAIVPKSSIVPRMTQASDIIRQNIANGVTVPSCINYITGPSNSADI EMDLVVGVHGPVKAAYILVSDR*" /label="lutC CDS" gene complement(2983900..2984622) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /label="lutC gene" downshifts complement(2983916) /Source="Nicolas_upshifts" /id="D1771" /incds=0 /nref=194 /ntot=266 /MaxReadThrough="4.5919" /MaxDrop="7.41457" /score="25.5917046" /energy="-15.7" /TU="U2689" /idTUdmin="U2689" /TUdmin="-1423" /isTUend="FALSE" /label="downshifts" CDS complement(2984622..2986061) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase linked to L-lactate utilization" /protein_id="NP_391284.1" /db_xref="EnsemblGenomes-Gn:BSU34040" /db_xref="EnsemblGenomes-Tr:CAB15409" /db_xref="GOA:O07021" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR004452" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR022825" /db_xref="InterPro:IPR024569" /db_xref="SubtiList:BG12448" /db_xref="UniProtKB/Swiss-Prot:O07021" /translation="MAMKIGTDAFKERVSQGIDNEFMRGAVSGAQERLRTRRLEAAEE LGNWEEWRSLSEEIRQHVLENLDFYLGQLAENVAKRGGHVYFAKTAEEASSYIRDVIQ KKNGKKIVKSKSMVTEEINLNEVLEKEGCEVVETDLGEYILQIDDHDPPSHIVAPALH KNKEQIRDVFKERLDYQHTEKPEELVMHARAILRKKFLEADIGITGCNFAIADTGSVS LVTNEGNGRLVSTLPKTQITVMGMERIVPSFSEFEVLVSMLTRSAVGQRLTSYITALT GPKLEGEVDGPEEFHLVIVDNGRSNILGTEFQSVLQCIRCAACINVCPVYRHVGGHSY GSIYSGPIGAVLSPLLGGYDDYKELPYASSLCAACSEACPVKIPLHELLLKHRQNIVE KEGRAPISEKLAMKAFGLGASSLSLYKMGSKWAPAAMTPFTEDEKISKGPGPLKNWTQ IRDFPAPHKSRFRDWFADRETSERTKEEQ*" /label="lutB CDS" gene complement(2984622..2986061) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /label="lutB gene" promotor_-35 2985609..2985612 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2985629 /Source="Nicolas_upshifts" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2985630..2985634 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2985783 /Source="Nicolas_upshifts" /id="D1772" /incds=1 /nref=1 /ntot=175 /MaxReadThrough="1.77859" /MaxDrop="3.31917" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2686" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 2985937 /Source="Nicolas_upshifts" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2985938..2985939 /Source="Nicolas_upshift_promotors" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2986088..2986804) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /EC_number="1.8.98.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-sulfur oxidase subunit used in L-lactate utilization" /protein_id="NP_391285.1" /db_xref="EnsemblGenomes-Gn:BSU34050" /db_xref="EnsemblGenomes-Tr:CAB15410" /db_xref="GOA:O07020" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR022822" /db_xref="SubtiList:BG12447" /db_xref="UniProtKB/Swiss-Prot:O07020" /translation="MKVSLFVTCLVDMFQTNVGKATVELLERLGCEVDFPEGQICCGQ PAYNSGYVHDAKKAMKRMIETFQDSEYVVSPSGSCTTMFREYPHLFQDDPKWADKAKK LADKTYELTDFIVNVLGVEDVGATLHTKATLHTSCHMTRLLGVRKEPMKLLSHVKGLQ FTELPGKHNCCGFGGTFSVKMAQISEQMVDEKVECVEETGAEVLIGADCGCLMNIGGR LGRKDKNVKVMHIAEVLNSR*" /label="lutA CDS" gene complement(2986088..2986804) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /label="lutA gene" promotor_-35 2986708..2986715 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2986729..2986731 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2986729 /Source="Nicolas_upshifts" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2986802 /Source="Nicolas_upshifts" /id="D1773" /incds=0 /nref=15 /ntot=169 /MaxReadThrough="1.96527" /MaxDrop="4.662" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2688" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" S_feature complement(2986805..2986871) /Source="Nicolas_S_feature" /locus_tag="new_3495702_3495768_c" /HighExp="C90, M40t90, T3.0H, T4.0H, HiOs, T1.0H, T3.30H, T2.30H, Lbstat, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1306" promotor_-10 complement(2986868..2986887) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-10" upshifts complement(2986871) /Source="Nicolas_upshifts" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="upshifts" promotor_-35 complement(2986902..2986909) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-35" CDS complement(2986979..2987581) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvfT]" /protein_id="NP_391286.1" /db_xref="EnsemblGenomes-Gn:BSU34060" /db_xref="EnsemblGenomes-Tr:CAB15411" /db_xref="GOA:O07019" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12446" /db_xref="UniProtKB/Swiss-Prot:O07019" /translation="MIRLFIAEDQRMLLGALGSLLDLEEDMTVIGQALNGEEALHAIL KLEPDVCIMDIEMPVRSGLNVAEELMKKGCVSKVIILTTFARPGYFERAVKAGAHGYL LKDGEIDDLADAIRKCVKGKRVFSPELTFNMMRDENPLTVREQEILRLAALGKTTKDI TLELYLSQGTVRNYISEIIQKLNAKNRTEAASIAEEKGWI*" /label="yvfU CDS" gene complement(2986979..2987581) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /label="yvfU gene" CDS complement(2987598..2988713) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YvfU]" /protein_id="NP_391287.2" /db_xref="EnsemblGenomes-Gn:BSU34070" /db_xref="EnsemblGenomes-Tr:CAB15412" /db_xref="GOA:Q795K2" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12445" /db_xref="UniProtKB/Swiss-Prot:Q795K2" /translation="MKKAISIFPKEFGFFPYIFLVYTIMPFLSLLKESGVKQGIGYGM LLLFVAAYRQLFCSVGKASFTYWLIVQMAVILMYSVFYNITYIYLGFFPANFVGYYKE KTNFNRAFCALIFILLFPCLYQFIANSVSLRELFSVLPFLVIMLISPFGIRSMFRRIE LEAKLAQANEQIKELSKREERVRIARDLHDTLGHTLSLLTLKSQLIQRLAASDPERTK LEAKEMETSSRSALKQVRELVSDMRTVTITEELVNIQHILRAGNITFQYEGADDFSVI SPVTQNIISMCMREAVTNIIKHSKATHCAITISQFADKMRIVIRDDGKGAPKEKMFGN GLWGMEERLMLIEGGLTVSDHNGTVVALTIPLIKKAE*" /label="yvfT CDS" gene complement(2987598..2988713) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /label="yvfT gene" CDS complement(2988717..2989454) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391288.1" /db_xref="EnsemblGenomes-Gn:BSU34080" /db_xref="EnsemblGenomes-Tr:CAB15413" /db_xref="GOA:O07017" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12444" /db_xref="UniProtKB/Swiss-Prot:O07017" /translation="MNVLQKQSIAEMKRVLRNKYFVLWSLIMPIAFYYFFTNVVNTNV PDQRAWEAHYLMSMTVFSVMGSSIMTLGIRMVQERSQGWAAFIRLTPLPDHIYLSAQM IGQSVIHVLSITVIFLFGAIINDIALSPFEWMMSGLWILFGALPFLALGTLIGLMRKV ETAAGISNVLYMLLALGGGMWMPFEVMPDMMQSIGQWLPSYHFGSGAWELVRGGSPTW KNILILIAYMMLFMLLSKYIRRKQEAV*" /label="yvfS CDS" gene complement(2988717..2989454) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /label="yvfS gene" promotor_-10 complement(2988743..2988762) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-10" upshifts complement(2988757) /Source="Nicolas_upshifts" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="upshifts" promotor_-35 complement(2988774..2988781) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-35" CDS complement(2989455..2990360) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_391289.1" /db_xref="EnsemblGenomes-Gn:BSU34090" /db_xref="EnsemblGenomes-Tr:CAB15414" /db_xref="GOA:O07016" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12443" /db_xref="UniProtKB/Swiss-Prot:O07016" /translation="MMKEAVTVSNVTKHFQRKTAVNNISFSIEKGEIAAILGPNGAGK TTVVSMILGLLKPSEGEIKLFNRVPDDQQVREKIGVMLQEVSVMPGLKVDEILELFRS YYPNPLSMKELVSLTALTKEDLKTRAEKLSGGQKRRLSFALALAGNPELLILDEPTVG MDTSSRHRFWQTIHGLSDQGKTIIFSTHYLQEADDAAQRILFFTEGQLVADGSPMQIR SRIQKQSVSFTLHSSESLERLSCHPEVERVIHEHERTIIQTSNTDKVLALIFQENIHA RDIRIEQATLDEAFRQLADGNREAM*" /label="yvfR CDS" gene complement(2989455..2990360) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /label="yvfR gene" promotor_-10 complement(2990380..2990398) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2990391) /Source="Nicolas_upshifts" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2990414..2990417) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2990569..2990576 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2990587..2990606 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2990594 /Source="Nicolas_upshifts" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="upshifts" CDS 2990644..2991453 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11591687, 12620626, 15632289, 21980452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591687, 12620626, 15632289, 21980452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of RsbP phosphatase" /protein_id="NP_391290.1" /db_xref="EnsemblGenomes-Gn:BSU34100" /db_xref="EnsemblGenomes-Tr:CAB15415" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR031143" /db_xref="PDB:1WOM" /db_xref="PDB:1WPR" /db_xref="SubtiList:BG12442" /db_xref="UniProtKB/Swiss-Prot:O07015" /translation="MNEAILSRNHVKVKGSGKASIMFAPGFGCDQSVWNAVAPAFEED HRVILFDYVGSGHSDLRAYDLNRYQTLDGYAQDVLDVCEALDLKETVFVGHSVGALIG MLASIRRPELFSHLVMVGPSPCYLNDPPEYYGGFEEEQLLGLLEMMEKNYIGWATVFA ATVLNQPDRPEIKEELESRFCSTDPVIARQFAKAAFFSDHREDLSKVTVPSLILQCAD DIIAPATVGKYMHQHLPYSSLKQMEARGHCPHMSHPDETIQLIGDYLKAHV*" /label="rsbQ CDS" gene 2990644..2991453 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /label="rsbQ gene" CDS 2991489..2992700 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /EC_number="3.1.3.3" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine protein-phosphatase" /protein_id="NP_391291.1" /db_xref="EnsemblGenomes-Gn:BSU34110" /db_xref="EnsemblGenomes-Tr:CAB15416" /db_xref="GOA:O07014" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG12441" /db_xref="UniProtKB/Swiss-Prot:O07014" /translation="MDKQLNDAPCGFLALSEEGSIIAANRTLIKILDYEPEQVIGQHM NMMLTIPAQLFCQLYFFPLLKLEHHIEEIYISLKARDGEEIPVLINAIARHDSGASVF DCVLIPMRKRNEYENELLIARNEAQEALLAKQKANAELEIALETLKAKQEELLEINKQ NQQFKLNTKRELELARKIQKNSLTEPIVNDQVQIDSYYNASSELSGDLYGYYQIDEHR YGIIILDVMGHGISSALITMSLHPLFQRQITQGLSPVKVMKELDRHLHSLFQNDEEAR HYCTAIYLEIDIARQRIDYVNAGHPPALWQDDSGTQHLLHATSPPIGMFEDLEFQSSS LSYTEDGRLLLYTDGVMDPTASCYLFDLLKDHPDSPIADLKEKILTSLQHQKEAHHKS DDECFILVDVK*" /label="rsbP CDS" gene 2991489..2992700 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /label="rsbP gene" downshifts 2992687 /Source="Nicolas_upshifts" /id="D1774" /incds=0 /nref=181 /ntot=246 /MaxReadThrough="0.90827" /MaxDrop="5.41923" /score="26.3528321" /energy="-17.8" /TU="NA" /idTUdmin="U2692" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2992754..2994043) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11682178, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,4-galactanase" /protein_id="NP_391292.2" /db_xref="EnsemblGenomes-Gn:BSU34120" /db_xref="EnsemblGenomes-Tr:CAB15417" /db_xref="GOA:O07013" /db_xref="InterPro:IPR011683" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12440" /db_xref="UniProtKB/Swiss-Prot:O07013" /translation="MKSKVKMFFAAAIVWSACSSTGYAAAIEKEKHVSELRAEDLFVK KVEGMNKDFIKGADVSSVIALENSGVTFYNTNGKRQDIFTTLKQAGVNYVRVRIWNHP YDSNGNGYGGGNNDVQKAIEIGKRATANGMKVLADFHYSDFWADPAKQKVPKAWANLS FEAKKAKLYEYTKQSLQKMIKEGVDIGMVQVGNETTGGFAGETDWTKMCQLFNEGSRA VRETNSNILVALHFTNPETAGRYSFIAETLSKNKVDYDVFASSYYPFWHGTLQNLTSV LKAVANTYGKKVMVAETSYTYTAEDGDGHGNTAPKSGQTLPYPISVQGQATAVRDVME AVANTGKAGLGVFYWEPAWIPVGPKTQIEKNKVLWETYGSGWASSYAAEYDPEDAGKW YGGSAVDNQALFDFNGHPLPSLQVFQYAESGHIPKKR*" /label="ganB CDS" gene complement(2992754..2994043) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /label="ganB gene" CDS complement(2994123..2996186) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /EC_number="3.2.1.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="short chain beta-1,4-galacto-oligosaccharides beta-galactosidase (beta-galacto-pyranoside hydrolase)" /protein_id="NP_391293.1" /db_xref="EnsemblGenomes-Gn:BSU34130" /db_xref="EnsemblGenomes-Tr:CAB15418" /db_xref="GOA:O07012" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12439" /db_xref="UniProtKB/Swiss-Prot:O07012" /translation="MMSKLEKTHVTKAKFMLHGGDYNPDQWLDRPDILADDIKLMKLS HTNTFSVGIFAWSALEPEEGVYQFEWLDDIFERIHSIGGRVILATPSGARPAWLSQTY PEVLRVNASRVKQLHGGRHNHCLTSKVYREKTRHINRLLAERYGHHPALLMWHISNEY GGDCHCDLCQHAFREWLKSKYDNSLKTLNHAWWTPFWSHTFNDWSQIESPSPIGENGL HGLNLDWRRFVTDQTISFYENEIIPLKELTPDIPITTNFMADTPDLIPYQGLDYSKFA KHVDAISWDAYPVWHNDWESTADLAMKVGFINDLYRSLKQQPFLLMECTPSAVNWHNV NKAKRPGMNLLSSMQMIAHGSDSVLYFQYRKSRGSSEKLHGAVVDHDNSPKNRVFQEV AKVGETLERLSEVVGTKRPAQTAILYDWENHWALEDAQGFAKATKRYPQTLQQHYRTF WEHDIPVDVITKEQDFSPYKLLIVPMLYLISEDTVSRLKAFTADGGTLVMTYISGVVN EHDLTYTGGWHPDLQAIFGVEPLETDTLYPKDRNAVSYRSQIYEMKDYATVIDVKTAS VEAVYQEDFYARTPAVTSHEYQQGKAYFIGARLEDQFQRDFYEGLITDLSLSPVFPVR HGKGVSVQARQDQDNDYIFVMNFTEEKQLVTFDQSVKDIMTGDILSGDLTMEKYEVRI VVNTH*" /label="ganA CDS" gene complement(2994123..2996186) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /label="ganA gene" CDS complement(2996205..2997056) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17056685, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391294.1" /db_xref="EnsemblGenomes-Gn:BSU34140" /db_xref="EnsemblGenomes-Tr:CAB15419" /db_xref="GOA:O07011" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12438" /db_xref="UniProtKB/Swiss-Prot:O07011" /translation="MLADMKVRRYIRLLFSYLLLAFMAVIIVYPLLWTAGASFNPGNS LISTSIIPKHPTFDHYKELFAGKESLQYVQWYVNSMKISLFTMAGSLLCVTFTAYAFS RFRFKGRKYALTLFLLLQMIPQFSALIALFVLAQILGMINSHWLLILLYIGGLIPMNT YLMKGYMDSIPMDLDESAKIDGASSTRIFFQIILPLSKPMAAVVAMNGFTGPLGDFVL SSTILRTPESYTLPVGLFNLVNDVMGASYTTFAAGALLISIPVAVIFIMLQKNFVSGL TAGGTKG*" /label="ganQ CDS" gene complement(2996205..2997056) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /label="ganQ gene" CDS complement(2997060..2998316) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11160890, 15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 15849754, 16850406, 17056685, 27501980; Product type t : transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391295.1" /db_xref="EnsemblGenomes-Gn:BSU34150" /db_xref="EnsemblGenomes-Tr:CAB15420" /db_xref="GOA:O32261" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12437" /db_xref="UniProtKB/Swiss-Prot:O32261" /translation="MQHRQVALLLSIIPGLGQFYNKQWIKGIVFLFLGASFFAVFGDL LNMGFWGIFTLGTEVPRDNSVFLLAEGIIAVIVTCFGLAVYYVNLRDAFQSGKQRDEN KPLSSLKEQYQHIISEGYPYVVSGPSLFILIFAVIFPILFSFALAFTNYDLYHSPPAK LIDWVGFQTFANIFTVDIWRSTFFDVLAWTVVWTLAASTLQVTLGIFLAIIVNQKDLR FKRFFRTILILPWAVPGFVTILIFAGLFNDSFGAMNHDILAFFGIDPLPWMTDANWSR LALILMQGWLGFPYIFLVSTGVLQSIPDDLYEAATIDGASVFSKLRYITLPMVFIAMA PIIITQFTFNFNNFNIIYLFNGGGPAVTGSTAGGTDILVSWIYKLTMQSSQYSLAAAL TILLSVFVISIALWQFRQTKSFKEEA*" /label="ganP CDS" gene complement(2997060..2998316) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /label="ganP gene" CDS complement(2998356..2999621) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11682178, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="polygalactose / cyclodextrin-binding lipoprotein" /protein_id="NP_391296.1" /db_xref="EnsemblGenomes-Gn:BSU34160" /db_xref="EnsemblGenomes-Tr:CAB15421" /db_xref="GOA:O07009" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12436" /db_xref="UniProtKB/Swiss-Prot:O07009" /translation="MKMAKKCSVFMLCAAVSLSLAACGPKESSSAKSSSKGSELVVWE DKEKSNGIKDAVAAFEKEHDVKVKVVEKPYAKQIEDLRMDGPAGTGPDVLTMPGDQIG TAVTEGLLKELHVKKDVQSLYTDASIQSQMVDQKLYGLPKAVETTVLFYNKDLITEKE LPKTLEEWYDYSKKTADGSKFGFLALFDQIYYAESVMSGYGGYIFGKAKDGSYNPSDI GINNEGAVKGAALIQKFYKDGLFPAGIIGEQGINVLESLFTEGKAAAIISGPWNVEAF SNAGINYGITKLPKLENGKNMSSFIGVKSYNVSAFSKNEELAQELAVFLANEKNSKTR YEETKEVPAVKSLANDPAIMKSEAARAVTEQSRFSEPTPNIPEMNEIWTPADSALQTV ATGKADPKQALDQAAETAKGQIKAKHSGK*" /label="ganS CDS" gene complement(2998356..2999621) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /label="ganS gene" promotor_-10 complement(2999653..2999672) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2999675) /Source="Nicolas_upshifts" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2999687..2999694) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2999762..3000754) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 10486575, 17056685, 27501980, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 10486575, 17056685, 27501980, 28617843; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the galactan degradation operon (GanR / beta-1,4-galactobiose)" /protein_id="NP_391297.1" /db_xref="EnsemblGenomes-Gn:BSU34170" /db_xref="EnsemblGenomes-Tr:CAB15422" /db_xref="GOA:O07008" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12435" /db_xref="UniProtKB/Swiss-Prot:O07008" /translation="MATIKDIAQEAGFSISTVSRVLNNDESLSVPDETREKIYEAAEK LNYRKKTVRPLVKHIAFLYWLTDKEELEDVYFKTMRLEVEKLAKAFNVDMTTYKIADG IESIPEHTEGFIAVGTFSDEELAFLRNLTENGVFIDSTPDPDHFDSVRPDLAQMTRKT VNILTEKGHKSIGFIGGTYKNPNTNQDEMDIREQTFRSYMREKAMLDERYIFCHRGFS VENGYRLMSAAIDTLGDQLPTAFMIAADPIAVGCLQALNEKGIAIPNRVSIVSINNIS FAKYVSPPLTTFHIDIHELCKNAVQLLLEQVQDKRRTVKTLYVGAELIVRKSMN*" /label="ganR CDS" gene complement(2999762..3000754) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /label="ganR gene" downshifts complement(2999796) /Source="Nicolas_upshifts" /id="D1775" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="1.40325" /MaxDrop="2.80992" /score="14.7399792" /energy="-8.3" /TU="NA" /idTUdmin="U2694" /TUdmin=1111 /isTUend="FALSE" /label="downshifts" S_feature complement(3000884..3000933) /Source="Nicolas_S_feature" /locus_tag="new_3509781_3509830_c" /HighExp="Sw, BC, M0t90, M40t90, B60, Lbstat, Lbtran, S2, B36, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29208099999999998" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1307" downshifts complement(3000907) /Source="Nicolas_upshifts" /id="D1776" /incds=0 /nref=88 /ntot=240 /MaxReadThrough="1.88481" /MaxDrop="5.0699" /score="7.28170345" /energy="-13.7" /TU="NA" /idTUdmin="U2694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3000934..3001593) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18604637, 24196425, 25031425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18604637, 24196425, 25031425; Product type r: regulator" /codon_start=1 /transl_table=11 /product="L-lactate utilization global transcriptional regulator (GntR family)" /protein_id="NP_391298.2" /db_xref="EnsemblGenomes-Gn:BSU34180" /db_xref="EnsemblGenomes-Tr:CAB15423" /db_xref="GOA:O07007" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12434" /db_xref="UniProtKB/Swiss-Prot:O07007" /translation="MIKNGELKPGDKLDSVQALAESFQVSRSAVREALSALKAMGLVE MKQGEGTYLKEFELNQISQPLSAALLMKKEDVKQLLEVRKLLEIGVASLAAEKRTEAD LERIQDALKEMGSIEADGELGEKADFAFHLALADASQNELLKHLMNHVSSLLLETMRE TRKIWLFSKKTSVQRLYEEHERIYNAVAAGNGAQAEAAMLAHLTNVEDVLSGYFEENV Q*" /label="lutR CDS" gene complement(3000934..3001593) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /label="lutR gene" S_feature complement(3001594..3001699) /Source="Nicolas_S_feature" /locus_tag="new_3510491_3510596_c" /HighExp="M0t90, Lbstat, BC, M40t90, Lbtran, Sw, S2, B60, ferm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69672000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1308" promotor_-10 complement(3001691..3001710) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3001700) /Source="Nicolas_upshifts" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3001725..3001728) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3001752..3001759 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3001774..3001793 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3001774 /Source="Nicolas_upshifts" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="upshifts" S_feature 3001777..3001882 /Source="Nicolas_S_feature" /locus_tag="new_3510674_3510779" /HighExp="T1.30H, S1, T1.0H, M40t90, T2.0H, M0t90, T3.0H, T2.30H, T0.30H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1309" promotor_-10 complement(3001783..3001800) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3001787) /Source="Nicolas_upshifts" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3001808..3001814) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3001883..3003574 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25031425; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_391299.1" /db_xref="EnsemblGenomes-Gn:BSU34190" /db_xref="EnsemblGenomes-Tr:CAB15424" /db_xref="GOA:P71067" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG11875" /db_xref="UniProtKB/Swiss-Prot:P71067" /translation="MQWTQAYTPIGGNLLLSALAALVPIIFFFWALAIKRMKGYTAGL ATLGIALIIAVLVYRMPAEKALMSATQGAVYGLLPIGWIIVTSVFLYKITVKTGQFDI IRSSVLSITDDRRLQALLIAFSFGAFLEGAAGFGAPVAISAALLVGLGFNPLYAAGIC LIANTAPVAFGAIGIPITAVEGPTGIPAMEISQMVGRQLPFLSVFIPLYLIIIMSGFR KALEIWPAILVSGVSFAVVQYLSSNFLGPELPDVLSALVSMAALAVFLKWWKPKTTFR FAGEQESAASIETARTNPAAPAYRGGQIFKAWSPFLLLTAMISVWGIPSVKSALTGHY EGSAVFLKWLNAVGEKLTFSPGVPFLNNQIVNADGTPIEAVYKLEVLGSAGTAILIAA VLSKFITAISWKDWGTVFKETVQELKLPILTIASVVGFAYVTNSSGMSTTLGMTLALT GSMFTFFSPVLGWLGVFITGSDTSANLLFGNLQKVTALSVGMDPVLSVAANSSGGVTG KMISPQSIAVACAAVGLAGKESDLFRFTIKHSLFLLLLVCIITFLQHHVFSWMIP*" /label="lutP CDS" gene 3001883..3003574 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /label="lutP gene" downshifts 3003559 /Source="Nicolas_upshifts" /id="D1777" /incds=0 /nref=153 /ntot=245 /MaxReadThrough="4.82757" /MaxDrop="5.44233" /score="20.8815301" /energy="-11.7" /TU="NA" /idTUdmin="U2695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3003601..3004911) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11274109, 12533460, 12634342, 16166551, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 12533460, 12634342, 16166551, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-54 factor (sigma-L)" /protein_id="NP_391300.1" /db_xref="EnsemblGenomes-Gn:BSU34200" /db_xref="EnsemblGenomes-Tr:CAB15425" /db_xref="GOA:P24219" /db_xref="InterPro:IPR000394" /db_xref="InterPro:IPR007046" /db_xref="InterPro:IPR007634" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10748" /db_xref="UniProtKB/Swiss-Prot:P24219" /translation="MDMKLQQVQVLKPQLTQELRQAITLLGYHSAELAEYIDELSLEN PLIERKETDTPPLSYHKTNKNRMNAQEAGLQLSNPQKTLQDALKQQSLDMNLTNTEKK IFNYLIHSLDSNGYLEEDIEEAARRLSVSAKEAEAVLAKLQSLEPAGIGARSLQECIL LQLQRLPNRNEQAEMLVSAHFDAFAQKKWKTLSVETGIPLHTIQDISDDIAALHPRPG LLFARPEQDVYIEPDIFITVKNGHIAAELNTRSFPEIDLHPQYRTLLSSGSCQDTVSY LSAKYQEWRWLSRALRQRKQTITRIINELITRQKDFFLKGRSAMKPLTLREVADCLSL HESTVSRAIKGKTIQTPYGLFEMKLFFSAKAEASGDGDASNYAVKTHLENLINQEDKT KPLSDQKLVDLLYEQHGIQISRRTVAKYRDQMNIPSSAARKRYK*" /label="sigL CDS" gene complement(3003601..3004911) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /label="sigL gene" S_feature 3003604..3004674 /Source="Nicolas_S_feature" /locus_tag="new_3512501_3513571" /HighExp="M9-stat, T1.30H, S1, Sw, T1.0H, T2.0H, T0.30H, G/S, T3.30H, T2.30H" /AntisenseName="sigL" /AntisenseCor="0.63927172079726402" /AntisenseRegPval="-31.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1310" downshifts complement(3003613) /Source="Nicolas_upshifts" /id="D1778" /incds=0 /nref=62 /ntot=219 /MaxReadThrough="2.33779" /MaxDrop="5.56948" /score="28.2409666" /energy="-11.7" /TU="NA" /idTUdmin="U2698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 3004731..3004750 /Source="Nicolas_upshift_promotors" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3004731..3004989 /Source="Nicolas_S_feature" /locus_tag="new_3513628_3513886" /HighExp="LBGstat, LBGexp, G180, Paraq, H2O2, LBGtran, Oxctl, Lbexp, dia0, HPh" /AntisenseName="sigL" /AntisenseCor="-0.50245218771496702" /AntisenseRegPval="-17.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1311" upshifts 3004731 /Source="Nicolas_upshifts" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3004925..3004944) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3004940) /Source="Nicolas_upshifts" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3004959..3004962) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3004990..3005208 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391301.1" /db_xref="EnsemblGenomes-Gn:BSU34210" /db_xref="EnsemblGenomes-Tr:CAB15426" /db_xref="InterPro:IPR018590" /db_xref="PDB:2GSV" /db_xref="PDB:2JS1" /db_xref="SubtiList:BG11876" /db_xref="UniProtKB/Swiss-Prot:P71066" /translation="MSELFSVPYFIENLKQHIEMNQSEDKIHAMNSYYRSVVSTLVQD QLTKNAVVLKRIQHLDEAYNKVKRGESK*" /label="yvfG CDS" gene 3004990..3005208 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /label="yvfG gene" downshifts 3005187 /Source="Nicolas_upshifts" /id="D1779" /incds=0 /nref=53 /ntot=250 /MaxReadThrough="3.27525" /MaxDrop="4.21929" /score="-0.306638574" /energy="-13.4" /TU="U2697" /idTUdmin="U2697" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" SCAR join(3005215,3005222) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs26" N_region 3005216..3005221 /note="EcoR site (GAATTC)" /created_by="User" /modified_by="User" /label="IIG_Bs26" promotor_-35 3005253..3005256 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3005262 /Source="Nicolas_upshifts" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3005273..3005291 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3005307..3006776 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7828905, 15138843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7828905, 15138843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="para-nitrobenzyl esterase (intracellular esterase B)" /protein_id="NP_391319.1" /db_xref="EnsemblGenomes-Gn:BSU34390" /db_xref="EnsemblGenomes-Tr:CAB15444" /db_xref="GOA:P37967" /db_xref="InterPro:IPR000997" /db_xref="InterPro:IPR002018" /db_xref="InterPro:IPR019819" /db_xref="InterPro:IPR019826" /db_xref="InterPro:IPR029058" /db_xref="PDB:1C7I" /db_xref="PDB:1C7J" /db_xref="PDB:1QE3" /db_xref="SubtiList:BG11844" /db_xref="UniProtKB/Swiss-Prot:P37967" /translation="MTHQIVTTQYGKVKGTTENGVHKWKGIPYAKPPVGQWRFKAPEP PEVWEDVLDATAYGSICPQPSDLLSLSYTELPRQSEDCLYVNVFAPDTPSKNLPVMVW IHGGAFYLGAGSEPLYDGSKLAAQGEVIVVTLNYRLGPFGFLHLSSFNEAYSDNLGLL DQAAALKWVRENISAFGGDPDNVTVFGESAGGMSIAALLAMPAAKGLFQKAIMESGAS RTMTKEQAASTSAAFLQVLGINEGQLDKLHTVSAEDLLKAADQLRIAEKENIFQLFFQ PALDPKTLPEEPEKAIAEGAASGIPLLIGTTRDEGYLFFTPDSDVHSQETLDAALEYL LGKPLAEKVADLYPRSLESQIHMMTDLLFWRPAVAYASAQSHYAPVWMYRFDWHPKKP PYNKAFHALELPFVFGNLDGLERMAKAEITDEVKQLSHTIQSAWITFAKTGNPSTEAV NWPAYHEETRETLILDSEITIENDPESEKRQKLFPSKGE*" /label="pnbA CDS" gene 3005307..3006776 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /label="pnbA gene" downshifts 3006753 /Source="Nicolas_upshifts" /id="D1780" /incds=0 /nref=4 /ntot=150 /MaxReadThrough="3.66738" /MaxDrop="2.70933" /score="-9.70074934" /energy="-12.2" /TU="U2703" /idTUdmin="U2703" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS 3006779..3006970 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514003.1" /translation="MGKTGYIGAAIVVAACIIILSAVVCLRDTVYYQPMRWTGIILFF AGIVMVPAYSAKRKPGKEK*" /label="hypothetical protein CDS" gene 3006779..3006970 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /label="gene" downshifts 3006949 /Source="Nicolas_upshifts" /id="D1781" /incds=0 /nref=24 /ntot=181 /MaxReadThrough="-0.096" /MaxDrop="4.20686" /score="34.8993337" /energy="-22.3" /TU="NA" /idTUdmin="U2703" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(3006997..3007482) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /EC_number="4.1.1.102" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9546183, 12903944, 17295427, 18326577, 21685295, 26658822" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9546183, 12903944, 17295427, 18326577, 21685295, 26658822; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase" /protein_id="NP_391320.1" /db_xref="EnsemblGenomes-Gn:BSU34400" /db_xref="EnsemblGenomes-Tr:CAB15445" /db_xref="GOA:O07006" /db_xref="InterPro:IPR008729" /db_xref="InterPro:IPR012674" /db_xref="PDB:2P8G" /db_xref="PDB:4ALB" /db_xref="SubtiList:BG12433" /db_xref="UniProtKB/Swiss-Prot:O07006" /translation="MENFIGSHMIYTYENGWEYEIYIKNDHTIDYRIHSGMVAGRWVR DQEVNIVKLTEGVYKVSWTEPTGTDVSLNFMPNEKRMHGIIFFPKWVHEHPEITVCYQ NDHIDLMKESREKYETYPKYVVPEFAEITFLKNEGVDNEEVISKAPYEGMTDDIRAGR L*" /label="padC CDS" gene complement(3006997..3007482) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /label="padC gene" CDS complement(3007505..3007816) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="EnsemblGenomes-Gn:BSU34410" /db_xref="EnsemblGenomes-Tr:CAB15446" /db_xref="GOA:O07005" /db_xref="InterPro:IPR011250" /db_xref="InterPro:IPR020915" /db_xref="PSEUDO:CAB15446.2" /db_xref="SubtiList:BG12432" /db_xref="UniProtKB/Swiss-Prot:O07005" /translation="MPGGADSQMIRANGRTDLSARYVIETADHELIYIENNGIRQVSK PFRKQAAAGEIIEPEHVYFRTVPTFETGSEVYQWLHDRLFIGSAERTPDYVLLDIYEV Q*" /label="yveG CDS" gene complement(3007505..3007816) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /pseudo /label="yveG gene" CDS complement(3007868..3007960) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU34420" /db_xref="EnsemblGenomes-Tr:CAB15447" /db_xref="PSEUDO:CAB15447.1" /db_xref="SubtiList:BG12431" /db_xref="UniProtKB/Swiss-Prot:O07004" /translation="MKKPVLKPFASLEIKVDPPITIGETSLGLR*" /label="yveF CDS" gene complement(3007868..3007960) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /pseudo /label="yveF gene" promotor_-10 complement(3008000..3008019) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3008017) /Source="Nicolas_upshifts" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3008033..3008040) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3008091..3008774) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /EC_number="5.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9987136, 19063962, 2054383, 28894939" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 19063962, 2054383, 28894939; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aminoacid racemase (prefers arginine, lysine and ornithine)" /protein_id="NP_391323.1" /db_xref="EnsemblGenomes-Gn:BSU34430" /db_xref="EnsemblGenomes-Tr:CAB15448" /db_xref="GOA:P32960" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004380" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="SubtiList:BG10391" /db_xref="UniProtKB/Swiss-Prot:P32960" /translation="MIGILAGMGPKSTSPFIDKVIDYCQKLYGASNDIDYPHMMIYSC PTPFYADRPIDHDEMKKAIIDGAVKLEKTGVDFIALPCNTAHVYYEEIQQALSVPMLH IVEETIKEIPHPAKKAVVLGTEPTIQSAIYQKVLKGNGQEVIHKDHWQQAVNQLIAAI KQPNHMQHTQALWQTLYEEISQHADIIISACTDLNAVLDHIQSEIPIIDSSACLAKST VSTYLAYQS*" /label="racX CDS" gene complement(3008091..3008774) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /label="racX gene" downshifts complement(3008109) /Source="Nicolas_upshifts" /id="D1782" /incds=0 /nref=122 /ntot=223 /MaxReadThrough="3.49026" /MaxDrop="5.32077" /score="5.15607483" /energy="-9.3" /TU="U2705" /idTUdmin="U2704" /TUdmin="-708" /isTUend="FALSE" /label="downshifts" CDS complement(3008790..3010145) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7592498, 9987136, 12533473, 14679248, 19063962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592498, 9987136, 12533473, 14679248, 19063962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4*" /protein_id="NP_391324.1" /db_xref="EnsemblGenomes-Gn:BSU34440" /db_xref="EnsemblGenomes-Tr:CAB15449" /db_xref="GOA:P32959" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR021860" /db_xref="SubtiList:BG10390" /db_xref="UniProtKB/Swiss-Prot:P32959" /translation="MKQNKRKHLQTLFETLGEKHQFNGTVLAAEGGDILYHHSFGYAE MTEKRPLKTNSLFELASLSKPFTALGIILLEEKGILGYEDKVDRWLPGFPYQGVTIRH LLNHTSGLPDYMGWFFANWDSHKIAVNQDIVDMLMNEGLSGYFEPNEGWMYSNTGYVL LAVIIEKASGMSYADFIKTSIFLPAGMNETRVYNRRLSPERIDHYAYGYVYDVHSETY VLPDELEETNYVVYLDGIQGDGTVNSVTSDLFRFDQALYQDDFISKASKESAFSPVRL NNGETIDYGFGWVLQNSPEKGRIVSHSGGWPGYSTMMIRYIDHRKTLIYLSNKEEDTE YEQAILKAAEHILFGQPYDVPERPADKKKKAIDTAIYSRYVGSYLLQDGTAAQVTTEN ERLYLEIAGQLRLELFPSSETRFFLRALSVEVEFTLGEDAAKSFILYEDGSEEEAVRT K*" /label="pbpE CDS" gene complement(3008790..3010145) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /label="pbpE gene" promotor_-10 complement(3010157..3010172) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3010173) /Source="Nicolas_upshifts" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3010184..3010193) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3010447..3010454 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3010468..3010487 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3010471 /Source="Nicolas_upshifts" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="upshifts" S_feature 3010493..3010683 /Source="Nicolas_S_feature" /locus_tag="new_3535821_3536011" /HighExp="G150, G180, G135, LBGexp, Mt0, Lbexp, LBGtran, dia0, GM 150, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.219024" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1314" CDS 3010684..3012105 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /EC_number="2.4.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levansucrase; levanase (moonlighting)" /protein_id="NP_391325.1" /db_xref="EnsemblGenomes-Gn:BSU34450" /db_xref="EnsemblGenomes-Tr:CAB15450" /db_xref="GOA:P05655" /db_xref="InterPro:IPR003469" /db_xref="InterPro:IPR023296" /db_xref="PDB:1OYG" /db_xref="PDB:1PT2" /db_xref="PDB:2VDT" /db_xref="PDB:3BYJ" /db_xref="PDB:3BYK" /db_xref="PDB:3BYL" /db_xref="PDB:3BYN" /db_xref="SubtiList:BG10388" /db_xref="UniProtKB/Swiss-Prot:P05655" /translation="MNIKKFAKQATVLTFTTALLAGGATQAFAKETNQKPYKETYGIS HITRHDMLQIPEQQKNEKYQVPEFDSSTIKNISSAKGLDVWDSWPLQNADGTVANYHG YHIVFALAGDPKNADDTSIYMFYQKVGETSIDSWKNAGRVFKDSDKFDANDSILKDQT QEWSGSATFTSDGKIRLFYTDFSGKHYGKQTLTTAQVNVSASDSSLNINGVEDYKSIF DGDGKTYQNVQQFIDEGNYSSGDNHTLRDPHYVEDKGHKYLVFEANTGTEDGYQGEES LFNKAYYGKSTSFFRQESQKLLQSDKKRTAELANGALGMIELNDDYTLKKVMKPLIAS NTVTDEIERANVFKMNGKWYLFTDSRGSKMTIDGITSNDIYMLGYVSNSLTGPYKPLN KTGLVLKMDLDPNDVTFTYSHFAVPQAKGNNVVITSYMTNRGFYADKQSTFAPSFLLN IKGKKTSVVKDSILEQGQLTVNK*" /label="sacB CDS" gene 3010684..3012105 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /label="sacB gene" downshifts 3012099 /Source="Nicolas_upshifts" /id="D1783" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.33324" /MaxDrop="3.39023" /score="9.57663013" /energy="-7.7" /TU="NA" /idTUdmin="U2706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3012179..3013729 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /EC_number="3.2.1.64" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11739774, 15528654, 26773563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11739774, 15528654, 26773563; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endolevanase, selectively cleaves the (beta-2,6)fructosyl bonds" /protein_id="NP_391326.1" /db_xref="EnsemblGenomes-Gn:BSU34460" /db_xref="EnsemblGenomes-Tr:CAB15451" /db_xref="GOA:O07003" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG12430" /db_xref="UniProtKB/Swiss-Prot:O07003" /translation="MNYIKAGKWLTVFLTFLGILLFIDLFPKEEHDQKTKSKQKPDYR AAYHFTTPDKWKNDPQKPIYFDGKYHYFYLYNRDYPKGNGTEWRHAVSEDLVHWTDEG VAIPKYTNPDGDIWTGSVVVDKENTAGFGKNALVAIVTQPSAKDKKQEQYLWYSTDKG KSFKFYSGNPVMPNPGTDDFRDPKVIWDDQDNKWVMVMAEGSKIGFYESDNLKDWHYT SGFFPEQAGMVECPDLYMMRASDGTNKWVLGASANGKPWGKPNTYAYWTGSFDGKEFK ADQTEAQWLDYGFDWYGGVTFEDSKSTDPLEKRYALAWMNNWDYANNTPTMKNGFNGT DSVIRELRLKEQDGTYSLVSQPIEALEQLTVSTDEIEDQDVNGSKTLSITGDTYQLDT DLSWSELKNAGVRLRESEDQKRHIDVGIFAEGGYAYVNRAATNQPDKSNTYVESKAPY DVNKRKVHLKILVDKTTIEVFVGDGKTVFSNEVFPKPEDKGITLYSDGGTASFKNITV KHFDSIHE*" /label="levB CDS" gene 3012179..3013729 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /label="levB gene" promotor_-35 3013773..3013779 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3013793..3013804 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3013793 /Source="Nicolas_upshifts" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="upshifts" CDS 3013837..3015399 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12730183, 15528654, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12730183, 15528654, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-aspartate/L-glutamate / proton permease" /protein_id="NP_391327.1" /db_xref="EnsemblGenomes-Gn:BSU34470" /db_xref="EnsemblGenomes-Tr:CAB15452" /db_xref="GOA:O07002" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12429" /db_xref="UniProtKB/Swiss-Prot:O07002" /translation="MSKQGNFQKSMSLFDLILIGMGAIFGSAWLFAVSNVASKAGPSG AFSWILGGAIILLIGLVYAELGAALPRTGGIIRYPVYSHGHLVGYLISFVTIVAYTSL ISIEVTAVRQYVAYWFPGLTIKGSDSPTISGWILQFALLCLFFLLNYWSVKTFAKANF IISIFKYIVPITIIIVLIFHFQPENLSVQGFAPFGFTGIQAAISTGGVMFAYLGLHPI VSVAGEVQNPKRNIPIALIICIIVSTIIYTVLQVTFIGAIPTETLKHGWPAIGREFSL PFKDIAVMLGLGWLATLVILDAILSPGGNGNIFMNTTSRLVYAWARNGTLFGIFSKVN KDTGTPRASLWLSFALSIFWTLPFPSWNALVNVCSVALILSYAIAPISSAALRVNAKD LNRPFYLKGMSIIGPLSFIFTAFIVYWSGWKTVSWLLGSQLVMFLIYLCFSKYTPKED VSLAQQLKSAWWLIGFYIMMLIFSYIGSFGHGLGIISNPVDLILVAIGSLAIYYWAKY TGLPKAAIDYDK*" /label="aspP CDS" gene 3013837..3015399 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /label="aspP gene" downshifts 3015377 /Source="Nicolas_upshifts" /id="D1784" /incds=0 /nref=12 /ntot=29 /MaxReadThrough="1.71122" /MaxDrop="3.47798" /score="-0.444529447" /energy="-11.7" /TU="NA" /idTUdmin="U2707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3015389..3016078 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391328.2" /db_xref="EnsemblGenomes-Gn:BSU34480" /db_xref="EnsemblGenomes-Tr:CAB15453" /db_xref="GOA:O07001" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:2F07" /db_xref="SubtiList:BG12428" /db_xref="UniProtKB/Swiss-Prot:O07001" /translation="MINKEARGFLASLFFTNKHTRDKMNESQSLLEVFLMPKQTSGKY EKILQAAIEVISEKGLDKASISDIVKKAGTAQGTFYLYFSSKNALIPAIAENLLTHTL DQIKGRLHGDEDFWTVLDILIDETFLITERHKDIIVLCYSGLAIDHSMEKWETIYQPY YSWLEKIINKAIANHEVTEGINSKWTARTIINLVENTAERFYIGFEQDENVEVYKKEI FTFLKRSLGTA*" /label="yvdT CDS" gene 3015389..3016078 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /label="yvdT gene" promotor_-35 3015428..3015435 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3015449..3015468 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3015458 /Source="Nicolas_upshifts" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="upshifts" downshifts 3016059 /Source="Nicolas_upshifts" /id="D1785" /incds=0 /nref=189 /ntot=242 /MaxReadThrough="4.85194" /MaxDrop="4.84113" /score="-0.444529447" /energy="-11.7" /TU="U2708" /idTUdmin="U2707" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(3016157) /Source="Nicolas_upshifts" /id="D1786" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="0.8852" /MaxDrop="3.45447" /score="0.398849185" /energy="-11.7" /TU="NA" /idTUdmin="U2709" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS 3016160..3016495 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22978536; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium / proton antiporter subunit A" /protein_id="NP_391329.1" /db_xref="EnsemblGenomes-Gn:BSU34490" /db_xref="EnsemblGenomes-Tr:CAB15454" /db_xref="GOA:O32262" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12427" /db_xref="UniProtKB/Swiss-Prot:O32262" /translation="MNWVLVFIAGLLEVVWASSLKHADSLLDWIIIFILIAVSFILLI RSYQKIPMAAAYTVFVGIGTVGTYLTGIVLGESFSAAQMFFLALLLAGILGMKLFTKE SKSQPGGEK*" /label="psmA CDS" gene 3016160..3016495 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /label="psmA gene" CDS 3016495..3016815 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11160890, 22978536; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium-proton two component antiporter subunit" /protein_id="NP_391330.1" /db_xref="EnsemblGenomes-Gn:BSU34500" /db_xref="EnsemblGenomes-Tr:CAB15455" /db_xref="GOA:O06999" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12426" /db_xref="UniProtKB/Swiss-Prot:O06999" /translation="MAWFLLVIAGIEEIIAAIAMKYIDGTRKKWPIIVMTVGFGLSFY CLSQAMIVLPAGVAYAVWTGIGSIGVSAVGLIWFKERFQLSQVISLCLILAGVIGLRL TSSS*" /label="psmB CDS" gene 3016495..3016815 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /label="psmB gene" S_feature 3016816..3017006 /Source="Nicolas_S_feature" /locus_tag="new_3542144_3542334" /HighExp="Sw, BC, BI, Lbstat, M0t90, Lbtran, M40t90, H2O2, S8, Paraq" /AntisenseName="yvdQ" /AntisenseCor="3.5547360410813897E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1315" CDS complement(3016851..3017363) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391331.1" /db_xref="EnsemblGenomes-Gn:BSU34510" /db_xref="EnsemblGenomes-Tr:CAB15456" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR021617" /db_xref="SubtiList:BG12425" /db_xref="UniProtKB/Swiss-Prot:O06998" /translation="MGILSGNPQDEPMHYGEVFGLWSYVMAGNKMVGNYQMLLNHVGD DDLKKLLRESIEKCQDEIKQVSTILKENGVALPPASPEPPTADLNDIPPGARFLDPDV AASAAAENAAGLVTCSKMMGQSIREDIAMMFGQFHMSKAATGAKYLRLLKNKGWLIPP PLHLQKHHEA*" /label="yvdQ CDS" gene complement(3016851..3017363) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /label="yvdQ gene" downshifts 3016983 /Source="Nicolas_upshifts" /id="D1787" /incds=1 /nref=6 /ntot=39 /MaxReadThrough="1.61612" /MaxDrop="4.65362" /score="0.608596632" /energy="-14.2" /TU="NA" /idTUdmin="U2708" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3017399..3017410) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3017405) /Source="Nicolas_upshifts" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3017425..3017431) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3017478..3017614) /Source="Nicolas_S_feature" /locus_tag="new_3542806_3542942_c" /HighExp="BT, S7, S8, S6, B36, G/S, S5, Pyr, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1316" downshifts complement(3017521) /Source="Nicolas_upshifts" /id="D1788" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.38169" /MaxDrop="2.9968" /score="15.2862513" /energy="-10.3" /TU="U2710" /idTUdmin="U2709" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" CDS complement(3017615..3018958) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /EC_number="1.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat protein; putative oxidoreductase" /protein_id="NP_391332.1" /db_xref="EnsemblGenomes-Gn:BSU34520" /db_xref="EnsemblGenomes-Tr:CAB15457" /db_xref="GOA:O06997" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12424" /db_xref="UniProtKB/Swiss-Prot:O06997" /translation="MGSTQLTGRVIFKGDPGYTEAIKNWNPYVDVYPLVFVFAQNSYD VSNAIKWARENKVPLRVRSGRHALDKNLSVVSGGIVIDVSDMNKVFLDEENAIATVQT GIPVGPLVKGLARDGFMAPFGDSPTVGIGGITMGGGFGVLSRSIGLISDNLLALKTVD AKGRIIHADQSHNEDLLWASRGGGGGNFGYNTQYTFKVHRAPKTATVFNIIWPWEQLE TVFKAWQKWAPFVDERLGCYLEIYSKINGLCHAEGIFLGSKTELIRLLKPLLHAGTPT EADIKTLYYPDAIDFLDPDEPIPGRNDQSVKFSSAWGHDFWSDEPISIMRKFLEDATG TEANFFFINWGGAISRVPKDETAFFWRHPLFYTEWTASWKNKSQEDSNLASVERVRQL MQPYVAGSYVNVPDQNIENFGKEYYGANFARLREIKAKYDPENVFRFPQSIPPSR*" /label="cotNP CDS" gene complement(3017615..3018958) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /label="cotNP gene" promotor_-10 complement(3018987..3019006) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3018995) /Source="Nicolas_upshifts" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3019019..3019028) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3019020..3019025 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3019041..3019059 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3019044 /Source="Nicolas_upshifts" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3019253..3019262 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3019271 /Source="Nicolas_upshifts" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3019276..3019295 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3019314..3020276 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 20378985" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 20378985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat lipolytic enzyme" /protein_id="NP_391333.1" /db_xref="EnsemblGenomes-Gn:BSU34530" /db_xref="EnsemblGenomes-Tr:CAB15458" /db_xref="GOA:O06996" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG12423" /db_xref="UniProtKB/Swiss-Prot:O06996" /translation="MAKYRIMTFDGGGTLGALSLQLLNRLARQNPKLISRTHVFSGNS IGSFTALALASGRSPRETLQYFEDEILPAFSISRPGGPVFNQQLPYSGFIKAVRNFFP ADLQLIDLRKRIVVPSFKLYSQKLDRWTPVLFHNFPGSPYLNEKVSDVILRSSGAPAT QRAYQNYVDGYVVATNPSTASIAFAVGKANVPLDQIAVLSIGTGEAPTRLRRDTRGWG MVSADNIRPENLKNLPPNWGVLLDRSPNEPLLPFLQMIAGGNGYYESMVSANLLGDRF FRLDPRIPNFSKTDPAVVPAVIEIANKTNLQPANQFIEKNWGSK*" /label="cotR CDS" gene 3019314..3020276 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /label="cotR gene" S_feature 3020277..3020530 /Source="Nicolas_S_feature" /locus_tag="new_3545605_3545858" /HighExp="BT, S8, S7, B36, S6, Pyr, G/S, S3, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1317" downshifts complement(3020557) /Source="Nicolas_upshifts" /id="D1789" /incds=0 /nref=190 /ntot=241 /MaxReadThrough="3.19421" /MaxDrop="5.60739" /score="16.7489574" /energy="-13.2" /TU="U2713" /idTUdmin="U2713" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" tRNA complement(3020561..3020636) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA (CCG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnQ-Arg tRNA" gene complement(3020561..3020636) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /label="trnQ-Arg gene" promotor_-10 complement(3020663..3020682) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3020684) /Source="Nicolas_upshifts" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3020698..3020701) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3020767..3020773 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3020783..3020858 /Source="Nicolas_S_feature" /locus_tag="new_3546111_3546186" /HighExp="Salt, S3, S4, Etha, S5, LoTm, Gly, M9-stat, BT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1318" upshifts 3020783 /Source="Nicolas_upshifts" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3020788..3020807 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3020835..3020842 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3020856..3020875 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3020860 /Source="Nicolas_upshifts" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="upshifts" CDS 3020906..3021499 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /EC_number="3.4.21.92" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease proteolytic subunit; Maxwell's demon" /protein_id="NP_391334.1" /db_xref="EnsemblGenomes-Gn:BSU34540" /db_xref="EnsemblGenomes-Tr:CAB15459" /db_xref="GOA:P80244" /db_xref="InterPro:IPR001907" /db_xref="InterPro:IPR018215" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR033135" /db_xref="PDB:3KTG" /db_xref="PDB:3KTH" /db_xref="PDB:3KTI" /db_xref="PDB:3KTJ" /db_xref="PDB:3KTK" /db_xref="PDB:3TT6" /db_xref="PDB:3TT7" /db_xref="SubtiList:BG19016" /db_xref="UniProtKB/Swiss-Prot:P80244" /translation="MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSI VSQLLFLAAEDPEKEISLYINSPGGSITAGMAIYDTMQFIKPKVSTICIGMAASMGAF LLAAGEKGKRYALPNSEVMIHQPLGGAQGQATEIEIAAKRILLLRDKLNKVLAERTGQ PLEVIERDTDRDNFKSAEEALEYGLIDKILTHTEDKK*" /label="clpP CDS" gene 3020906..3021499 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /label="clpP gene" downshifts 3021488 /Source="Nicolas_upshifts" /id="D1790" /incds=0 /nref=292 /ntot=300 /MaxReadThrough="4.45406" /MaxDrop="8.24306" /score="30.2626808" /energy="-14.6" /TU="U2714" /idTUdmin="U2715" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" S_feature 3021533..3021931 /Source="Nicolas_S_feature" /locus_tag="new_3546861_3547259" /HighExp="Etha, dia15, Heat, LoTm, M9-stat, Gly, dia5, Diami, S8, H2O2" /AntisenseName="pgcM" /AntisenseCor="0.13310786898312499" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1319" CDS complement(3021545..3022225) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /EC_number="2.7.1.41" /EC_number="5.4.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 11081794, 15996095" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 11081794, 15996095; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional beta-phosphoglucomutase / glucose-1-phosphate phosphodismutase" /protein_id="NP_391335.1" /db_xref="EnsemblGenomes-Gn:BSU34550" /db_xref="EnsemblGenomes-Tr:CAB15460" /db_xref="GOA:O06995" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR010972" /db_xref="InterPro:IPR010976" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3NAS" /db_xref="SubtiList:BG12422" /db_xref="UniProtKB/Swiss-Prot:O06995" /translation="MKAVIFDLDGVITDTAEYHFLAWKHIAEQIDIPFDRDMNERLKG ISREESLESILIFGGAETKYTNAEKQELMHRKNRDYQMLISKLTPEDLLPGIGRLLCQ LKNENIKIGLASSSRNAPKILRRLAIIDDFHAIVDPTTLAKGKPDPDIFLTAAAMLDV SPADCAAIEDAEAGISAIKSAGMFAVGVGQGQPMLGADLVVRQTSDLTLELLHEEWEQ YRIRESIP*" /label="mdxM CDS" gene complement(3021545..3022225) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /label="mdxM gene" downshifts complement(3021569) /Source="Nicolas_upshifts" /id="D1791" /incds=0 /nref=2 /ntot=36 /MaxReadThrough="3.4944" /MaxDrop="3.50516" /score="-9.43329271" /energy="-14.6" /TU="U2718" /idTUdmin="U2718" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" CDS complement(3022222..3023907) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9573215, 10229946, 1670768" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573215, 10229946, 1670768; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligo-1,4-1,6-alpha-glucosidase (sucrase-maltase-isomaltase)" /protein_id="NP_391336.1" /db_xref="EnsemblGenomes-Gn:BSU34560" /db_xref="EnsemblGenomes-Tr:CAB15461" /db_xref="GOA:O06994" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="PDB:4M56" /db_xref="PDB:4M8U" /db_xref="PDB:4MAZ" /db_xref="PDB:4MB1" /db_xref="SubtiList:BG12421" /db_xref="UniProtKB/Swiss-Prot:O06994" /translation="MSEWWKEAVVYQIYPRSFYDANGDGFGDLQGVIQKLDYIKNLGA DVIWLSPVFDSPQDDNGYDISDYKNMYEKFGTNEDMFQLIDEVHKRGMKIVMDLVVNH TSDEHAWFAESRKSKDNPYRDYYLWKDPKPDGSEPNNWGSIFSGSAWTYDEGTGQYYL HYFSKKQPDLNWENEAVRREVYDVMRFWMDRGVDGWRMDVIGSISKYTDFPDYETDHS RSYIVGRYHSNGPRLHEFIQEMNREVLSHYDCMTVGEANGSDIEEAKKYTDASRQELN MIFTFEHMDIDKEQNSPNGKWQIKPFDLIALKKTMTRWQTGLMNVGWNTLYFENHDQP RVISRWGNDRKLRKECAKAFATVLHGMKGTPFIYQGEEIGMVNSDMPLEMYDDLEIKN AYRELVVENKTMSEKEFVKAVMIKGRDHARTPMQWDAGKHAGFTAGDPWIPVNSRYQD INVKESLEDQDSIFFYYQKLIQLRKQYKIMIYGDYQLLQENDPQVFSYLREYRGEKLL VVVNLSEEKALFEAPPELIHERWKVLISNYPQERADLKSISLKPYEAVMGISI*" /label="mdxL CDS" gene complement(3022222..3023907) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /label="mdxL gene" CDS complement(3023900..3026173) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /EC_number="2.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16707683, 28527120" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 28527120; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose phosphorylase" /protein_id="NP_391337.1" /db_xref="EnsemblGenomes-Gn:BSU34570" /db_xref="EnsemblGenomes-Tr:CAB15462" /db_xref="GOA:O06993" /db_xref="InterPro:IPR005194" /db_xref="InterPro:IPR005195" /db_xref="InterPro:IPR005196" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR017045" /db_xref="SubtiList:BG12420" /db_xref="UniProtKB/Swiss-Prot:O06993" /translation="MINQRLFEIDEWKIKTNTFNKEHTRLLESLTSLANGYMGVRGNF EEGYSGDSHQGTYIAGVWFPDKTRVGWWKNGYPEYFGKVINAMNFMGIGLYVDGEKID LHQNPIELFEVELNMKEGILRRSAVVRIQDKTVRIRSERFLSLAVKELCAIHYEAECL TGDAVITLVPYLDGNVANEDSNYQEQFWQEEAKGADSHSGHLAAKTIENPFGTPRFTV LAAMANETEGFVHESFKTTEMYVENRYSYQTKASLKKFVIVTTSRDFREEELLSKAKE LLADVVENGYEDAKRRHTDRWKERWAKADIEIKGDEELQQGIRYNIFQLFSTYYGGDA RLNIGPKGFTGEKYGGAAYWDTEAYAVPMYLATAEPEVTKNLLLYRYHQLEAAKRNAA KLGMKGALYPMVTFTGDECHNEWEITFEEIHRNGAICYAIYNYINYTGDRNYMEEYGI DVLVAVSRFWADRVHFSKRKNKYMIHGVTGPNEYENNVNNNWYTNVIAAWTLEYTLQS LESISAEKRRHLDVQEVELEVWREIIQHMYYPFSEELQIFVQHDTFLDKDLQTVDELD PAERPLYQNWSWDKILRSNFIKQADVLQGIYLFNDRFTMEEKRRNFEFYEPMTVHESS LSPSVHAILAAELKLEKKALELYKRTARLDLDNYNHDTEEGLHITSMTGSWLAIVHGF AGMRTANETLSFAPFLPKEWDEYSFNINYRNRLINVTVDEKRVIFELVKGEPLHMNVY EEPVVLQGRCERRTPNE*" /label="mdxK CDS" gene complement(3023900..3026173) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /label="mdxK gene" CDS complement(3026151..3027035) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16707683, 16850406, 20436965; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative component of maltodextrin transporter" /protein_id="NP_391338.1" /db_xref="EnsemblGenomes-Gn:BSU34580" /db_xref="EnsemblGenomes-Tr:CAB15463" /db_xref="GOA:O06992" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG12419" /db_xref="UniProtKB/Swiss-Prot:O06992" /translation="MKNLENKSFIIRCLKAAASPSGVCRYGNTFSWLQLSFLFLFLTA CLMAPLAVSFVKMDRFSVSSFMPSAIQGVNDQFADQLQGFQIRNGKLTGGKSSERIED GQNVMAVDMKHEYETSGENGRLKVTGFENAIIFQPDQLVITDQNETGFSVGYAKMDVK LEKPNVHDVEVLIDTLWLAQYKPMIMMLAYTVVSMIQLLLTFVLAGGLWITKISNMVS IASFKEAASIAICASALPAFAAAAIGMVHFDLITVLMIHSCGVTLMISFAFRYLTKTR RDNGNLHSGGNDDKSAVI*" /label="mdxJ CDS" gene complement(3026151..3027035) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /label="mdxJ gene" CDS complement(3027041..3027877) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transporter (permease)" /protein_id="NP_391339.1" /db_xref="EnsemblGenomes-Gn:BSU34590" /db_xref="EnsemblGenomes-Tr:CAB15464" /db_xref="GOA:O06991" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12418" /db_xref="UniProtKB/Swiss-Prot:O06991" /translation="MNASTARMLNKICTYLFLTLLSIVIIYPLLITASSAFRVGNSAA FQLDFSGSWTLDHFKRLFDETLYLNWYSNTLVIALSVMVLQVTIVTLAGYSYSRYRFA GRKKSLIFFLIIQMVPTMAALTAFYVLAMLIGALDQYWFLTAIYIGGGIPMNTWLMKG YFDTVPREIDEAARIDGAGHLRIFASIVLPLVKPMLAVQALWAFMAPFGDYLLTKFLL RSPERLTIAVGLQSFISNPQQQKVALFAAGAILAALPICVLFFFLQKNFVSGLTAGGT KG*" /label="mdxG CDS" gene complement(3027041..3027877) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /label="mdxG gene" CDS complement(3027878..3029185) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transport system (permease)" /protein_id="NP_391340.1" /db_xref="EnsemblGenomes-Gn:BSU34600" /db_xref="EnsemblGenomes-Tr:CAB15465" /db_xref="GOA:O06990" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12417" /db_xref="UniProtKB/Swiss-Prot:O06990" /translation="MNKHHTLTKQKRKAGLLSIIPGLGQIANQQLSKGLLFLAITGLF AFELCVFGIQALTGLMTLGSVPGEDHSLFMLIEGTLQLIVTMIFLMFYIFNIHDSRKT AAMKAAGLEVNTTAKDMICHAGDKGFPYLFTLPAYIMMVFVIIFPVLVTLFVALTNYD FYHIPPNRLIDWVGFKNFLNIFFLGSYRETFVNVLGWTVIWTICATTLQIILGIVTAL FVNQDFIKGKRIFRMIFLFPWAVPAFITIMSFSNMFNDSIGAVNAQVIPLFNHLPFVE LPAIAWKTDPFWTKTALIMIQTWLGFPYIYVMVTGVLQAIPGELYEAAKIDGATFIQR FRHITFPMILFATAPVMITQYTFNFNNFSIIYLFNEGGPGSAGAGAGSTDILISWIYK LTTGTSPQYSVAAAVTLLISFIVIGISLIAFKKSNAFGNEEVM*" /label="mdxF CDS" gene complement(3027878..3029185) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /label="mdxF gene" promotor_-35 3028243..3028252 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3028265..3028284 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3028269 /Source="Nicolas_upshifts" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3029225..3030478) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="maltose/maltodextrin-binding lipoprotein" /protein_id="NP_391341.1" /db_xref="EnsemblGenomes-Gn:BSU34610" /db_xref="EnsemblGenomes-Tr:CAB15466" /db_xref="GOA:O06989" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12416" /db_xref="UniProtKB/Swiss-Prot:O06989" /translation="MVLLKKGFAILAASFLAIGLAACSSSKNPASSDGKKVLTVSVEE TYKEYIESIKTKFEKENDVTVKIVEKQMFEQLEALPLDGPAGNAPDVMLAAYDRIGGL GQQGHLLDIKPSNTKSFGDKEMQQVTVDGKVYGMPLVIETLILYYNKDLLKTAPKTFK DLEKLTEDPRFAFASEKGKSTGFLAKWTDFYMSYGLLAGYGGYVFGKNGTDSGDIGLN NKGAVEAVKYAEKWFETYWPKGMQDNSSADDFIQQMFLEGKAAAIIGGPWSAANYKEA KLNYGAAPIPTLPNGEEYAPFAGGKGWVASKYTKEPELAEKWLEYAANDANAYAFYED TNEVPANTAARKKADEQKNELTSAVIKQYETATPTPNIPEMAEVWTGAESLIFDAASG KKSTQTSANDAVNVIKENIKEKYVK*" /label="mdxE CDS" gene complement(3029225..3030478) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /label="mdxE gene" S_feature complement(3030479..3030573) /Source="Nicolas_S_feature" /locus_tag="new_3555807_3555901_c" /HighExp="T1.0H, T0.30H, BC, T1.30H, M40t90, M0t90, BI, B60, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.804" /TUlongSig="NA" /TUlongPSig="NA" /label="S1320" CDS complement(3030574..3032343) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10825545, 15650689, 16707683, 19465663, 27871383, 27871383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10825545, 15650689, 16707683, 19465663, 27871383, 27871383; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maltogenic alpha-amylase" /protein_id="NP_391342.1" /db_xref="EnsemblGenomes-Gn:BSU34620" /db_xref="EnsemblGenomes-Tr:CAB15467" /db_xref="GOA:O06988" /db_xref="InterPro:IPR004185" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013777" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12415" /db_xref="UniProtKB/Swiss-Prot:O06988" /translation="MMEYAAIHHQPFSTDAYSYDGRTVHIKIRTKKGDADHIRFIWGD PYEYNDGKWSANEQPMRKIAATEMHDYWFAEVVPPFRRLQYAFVVTDDHEDIFFGSSG VCPYNEKTLETIHYYFKFPFVHEADTFQAPEWVKSTVWYQIFPERFANGREDLSPKNA LPWGSKDPDVNDFFGGDLQGIVDKLDYLEDLGVNGIYLTPIFSAPSNHKYDTLDYFSI DPHFGDPELFRTLVSQLHQRGMRIMLDAVFNHIGSASPQWQDVVKNGDQSRYKDWFHI HSFPVTDDNYDRFAFTADMPKLNTANPEVQKYLLDIALYWIREFDIDGWRLDVANEVD HVFWKTFRQAVSTEKPDVYILGEIWHSAEPWLRGDEFHAAMNYPFTEPMIEYFADQTI SASRMAHRVNAHLMNGMKQANEVMFNLLDSHDTKRLLTRCRNDEKKARALLAFMFAQT GSPCIYYGTEIGLNGENDPLCRKCMVWEKEKQNQDMLQFMKRLIALRKQENTLLTEGH LEWNLLDDKNDFISFSRTLDEKILIYFFNQGNVVQHVSLRELNIDRNKKICDAWTEQP LQHHDVIAVQPGEFLILSAAAPV*" /label="mdxD CDS" gene complement(3030574..3032343) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /label="mdxD gene" promotor_-35 3032264..3032269 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3032285..3032303 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3032295 /Source="Nicolas_upshifts" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3032381..3032400) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3032394) /Source="Nicolas_upshifts" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3032413..3032420) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3032456..3033406) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16707683, 23951303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 23951303; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the maltodextrin operon (LacI family)" /protein_id="NP_391343.1" /db_xref="EnsemblGenomes-Gn:BSU34630" /db_xref="EnsemblGenomes-Tr:CAB15468" /db_xref="GOA:O06987" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12414" /db_xref="UniProtKB/Swiss-Prot:O06987" /translation="MATLSDVAKKANVSKMTVSRVINHPETVTDELKKLVHSAMKELN YIPNYAARALVQNRTQVVKLLILEEMDTTEPYYMNLLTGISRELDRNHYALQLVTRNS LNIGQCDGIIATGLRKNDFEGVIKAFEKPLVVFGQNEMGYDFIDVNNEKGTFMATRHV MGLGEREVVFFGIDLDEPFERAREQGYIRAMNKSFKKSNMFRIDNSSKKSECLARELL KSMDNQAAFVCASDRIALGVIRAAQSLGKRIPEDVAVTGNDGVFLDRISSPRLTTVRQ PVVEMGEACAKMLLKKMNEDGAAQGSLFFEPELIVRESTL*" /label="mdxR CDS" gene complement(3032456..3033406) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /label="mdxR gene" promotor_-10 complement(3033421..3033439) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3033434) /Source="Nicolas_upshifts" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3033451..3033459) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3033540) /Source="Nicolas_upshifts" /id="D1792" /incds=0 /nref=134 /ntot=243 /MaxReadThrough="0.22626" /MaxDrop="5.17193" /score="21.4455132" /energy="-10" /TU="NA" /idTUdmin="U2720" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3033612..3034187) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391344.1" /db_xref="EnsemblGenomes-Gn:BSU34640" /db_xref="EnsemblGenomes-Tr:CAB15469" /db_xref="InterPro:IPR005269" /db_xref="InterPro:IPR031100" /db_xref="PDB:1T35" /db_xref="SubtiList:BG12413" /db_xref="UniProtKB/Swiss-Prot:O06986" /translation="MKTICVFAGSNPGGNEAYKRKAAELGVYMAEQGIGLVYGGSRVG LMGTIADAIMENGGTAIGVMPSGLFSGEVVHQNLTELIEVNGMHERKAKMSELADGFI SMPGGFGTYEELFEVLCWAQIGIHQKPIGLYNVNGYFEPMMKMVKYSIQEGFSNESHL KLIHSSSRPDELIEQMQNYSYPILEKKWTEI*" /label="yvdD CDS" gene complement(3033612..3034187) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /label="yvdD gene" downshifts complement(3033624) /Source="Nicolas_upshifts" /id="D1793" /incds=0 /nref=30 /ntot=209 /MaxReadThrough="4.23893" /MaxDrop="3.6086" /score="21.4455132" /energy="-10" /TU="U2720" /idTUdmin="U2720" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3034230..3034249) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3034236..3034243 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3034246) /Source="Nicolas_upshifts" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="upshifts" upshifts 3034253 /Source="Nicolas_upshifts" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3034256..3034275 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3034264..3034271) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3034304..3034624 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16120674, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrophosphohydrolase" /protein_id="NP_391345.1" /db_xref="EnsemblGenomes-Gn:BSU34650" /db_xref="EnsemblGenomes-Tr:CAB15470" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011411" /db_xref="SubtiList:BG12412" /db_xref="UniProtKB/Swiss-Prot:O32263" /translation="MQLADAEKWMKEFYEKRGWTEYGPFIRVGFLMEEAGELARAVRA YEIGRDRPDEKESSRAEQKQELIEEMGDVIGNIAILADMYGVSLEDVMKAHQEKLTKR FEHA*" /label="yvdC CDS" gene 3034304..3034624 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /label="yvdC gene" downshifts 3034605 /Source="Nicolas_upshifts" /id="D1794" /incds=0 /nref=134 /ntot=247 /MaxReadThrough="2.19085" /MaxDrop="5.46819" /score="35.8658106" /energy="-11.6" /TU="NA" /idTUdmin="U2721" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3034651) /Source="Nicolas_upshifts" /id="D1795" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="0.462300000000001" /MaxDrop="6.90114" /score="30.4681035" /energy="-11.3" /TU="NA" /idTUdmin="U2722" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(3034651..3036243) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion transporter" /protein_id="NP_391346.1" /db_xref="EnsemblGenomes-Gn:BSU34660" /db_xref="EnsemblGenomes-Tr:CAB15471" /db_xref="GOA:O06984" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12411" /db_xref="UniProtKB/Swiss-Prot:O06984" /translation="MRFSGRFKGYNLQKFQKDLIAGIVVGVVAIPLGMAFAIASGVEP EYGLYTVVIAGICISLFGGSKYQIGGPTGAFVPILFGIIMQYGLENLLIAGFMAGVML VLFGLFKLGKIMKFVPKPVIVGFTAGIAVLIFTEQIANFLGLRNVEKHENFHHNMFEI VQQLGTFNVYAILTAVIGLVILLVSAKVMPKVPGALLALLISTVVAVVFFPDRMATIG STYGEIPRHLPEFQFPELTLDKMVMLFPAALVIALLGGLESILSAMVADNMKGSKHDS NKELVGQGIANMAAPLFGGIPATGAIARTATNIKNGAVSPVSGVVHGVVVLLVLLVFA PYASHVPLASMAPILMVVAWNMSERKEVANMLRLKNADSFILAATFALTVLFDLIIGV ATGLLLAFVFFIRRMSEATRIHNQETHPVLAKREDPSVSMYAIEGPLFFGSIDSLESS LLEHVQKKPKTLILLMNKVHYMDTSAEAVLGNIMNRIKRHNGKLMIVGLQSQPKELLH KTGLFHKIGKQHFFDHHDEITG*" /label="yvdB CDS" gene complement(3034651..3036243) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /label="yvdB gene" CDS complement(3036262..3036855) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /EC_number="4.2.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10611359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carbonic anhydrase" /protein_id="NP_391347.1" /db_xref="EnsemblGenomes-Gn:BSU34670" /db_xref="EnsemblGenomes-Tr:CAB15472" /db_xref="GOA:O06983" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG12410" /db_xref="UniProtKB/Swiss-Prot:O06983" /translation="MNQMVSLTSILEHNQRFVSEKKYEPYKTTKFPSKKLVIVTCMDT RLTELLPQAMGLKNGDAKIVKNAGAIVSHPFGSVMRSILVAIYELQAEEVCIVGHHEC GMSGLNASSILEKAKERGVEDSCLNLLTSAGLDLKTWLTGFHSVEESVSHSVNMIKNH PLLPKKVPVHGLVIHPETGKLDVVINGYETELINNHS*" /label="yvdA CDS" gene complement(3036262..3036855) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /label="yvdA gene" promotor_-10 complement(3036897..3036916) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3036910) /Source="Nicolas_upshifts" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3036931..3036935) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3036981..3036986 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3037002..3037020 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3037003 /Source="Nicolas_upshifts" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3037176..3037183 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3037197..3037216 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3037201 /Source="Nicolas_upshifts" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" CDS 3037238..3038215 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /EC_number="1.1.1.215" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811658, 25769838; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-ketogluconate reductase; hydroxypyruvate / glyoxylate reductase" /protein_id="NP_391348.1" /db_xref="EnsemblGenomes-Gn:BSU34680" /db_xref="EnsemblGenomes-Tr:CAB15473" /db_xref="GOA:O32264" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12409" /db_xref="UniProtKB/Swiss-Prot:O32264" /translation="MLKPFVFITKPIPEEIEAFIGEHCRYEVWQEDTLPSDVLFEKLK EAEGLLTSGTSGPSINRELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVGTHTPYTL DDTVADLAFSLILSSARRVAELDRFVRAGKWGTVEEEALFGIDVHHQTLGIIGMGRIG EQAARRAKFGFDMEVLYHNRHRKQETEDSIGVKYAELDTLLEQSDFILLITPLTDETY HMIGEREFKLMKNSAIFVNISRGKTVDEKALIRALQEGWIRGAGLDVYEKEPVTQDNP LLQLDNVTLLPHIGSATAKVRFNMCKQAAENMLAAIQGQTPKNLTREFQ*" /label="yvcT CDS" gene 3037238..3038215 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /label="yvcT gene" downshifts 3038187 /Source="Nicolas_upshifts" /id="D1796" /incds=0 /nref=223 /ntot=269 /MaxReadThrough="2.44036" /MaxDrop="5.93476" /score="1.05732532" /energy="-14.7" /TU="NA" /idTUdmin="U2724" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3038253..3040193) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (permease)" /protein_id="NP_391349.1" /db_xref="EnsemblGenomes-Gn:BSU34690" /db_xref="EnsemblGenomes-Tr:CAB15474" /db_xref="GOA:O06981" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG12408" /db_xref="UniProtKB/Swiss-Prot:O06981" /translation="MNLRTIARKNILGNLQRYVAYFLSCVFAVSVFFVFTSFIFHPDV NEDNIYGGSLVKTCLSAALVVIIVFCIFFITYSNSAFLQARKKEFGLLTLFGTSKQQL RKMIYYEQSLISLAAIAAGIGAGLLFSKLFFMIMTWMLSVKVPISFAIVPKAFVMTIA GFLILFQTLLILSLGRIRKLEIIELIKSAKKPKSLPVYSKWLTVLSLLCLGSGYYLSA TANAIDMMFRVFPILILVLIGTYFFFTQSSVAFFRMLYRKKHSFYKGTNIIVRSNMIF RLKDHARMLFLTSVITAVILTATGVIYMFYSDLQRQEEQSIPQSVSWVEKDASRFQVM KPETAENTLKKAHAVITYKVDATGIPVTFQSDLPYGNKKMEAEALLISEKVYNQVAKE KGFPVIHLQENEAFINVSFQMMVKDTFGEGETAAFHMKSGKTLSYVMKKQQNKGILMS VDGVSRLLVVSEKSFDSLSQDVPLKEQMRMVGYELEHWQETVDVSEKLENMVPKEHTS DFQTRAPSYQIVKQGVALMLFIGLFVSVLFFIVQGSMLYLRMFTEIEDTGVQVLALKR IGVTDKEIHSILGKQIGFLFFIPFIAGTIHAGFAYAALSNMLNSNLFLEAVIVIFIYF VFQALYYIVTRHIYKRAVLQRM*" /label="psdB CDS" gene complement(3038253..3040193) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /label="psdB gene" downshifts complement(3038277) /Source="Nicolas_upshifts" /id="D1797" /incds=0 /nref=11 /ntot=187 /MaxReadThrough="0.26118" /MaxDrop="4.59213" /score="26.9028733" /energy="-14.7" /TU="NA" /idTUdmin="U2725" /TUdmin=34 /isTUend="FALSE" /label="downshifts" CDS complement(3040168..3040947) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12432961, 14651641, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (ATP-binding protein)" /protein_id="NP_391350.1" /db_xref="EnsemblGenomes-Gn:BSU34700" /db_xref="EnsemblGenomes-Tr:CAB15475" /db_xref="GOA:O06980" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12407" /db_xref="UniProtKB/Swiss-Prot:O06980" /translation="MNVLQTTNLSKTYYSNKGTISYQALSAFDLSVSKGEFVGIMGPS GSGKTTLLNLLATIDKPTQGEMMINGIQPKTLKDQELALFRRRELGFVFQDFNLLDTL TIRENILLPLALDKVKLREMEARLDELADTLQIKHILDHRTYEVSGGQQQRAACARAI IHNPALILADEPTGNLDSKSAKQVMNTLAQLNEEKEATILLVTHDATAASFCKRIVFI KDGRFFSEIHRGTNRQVFYQSILDTLSVLGGDFHEFENYRP*" /label="psdA CDS" gene complement(3040168..3040947) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /label="psdA gene" S_feature complement(3040948..3041029) /Source="Nicolas_S_feature" /locus_tag="new_3566276_3566357_c" /HighExp="LBGtran, M0t45, H2O2, C30, Lbexp, Lbstat, LBGstat, dia0, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1321" CDS complement(3041030..3042100) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [PsdR] response to lantibiotics (nisin and gallidermin)" /protein_id="NP_391351.1" /db_xref="EnsemblGenomes-Gn:BSU34710" /db_xref="EnsemblGenomes-Tr:CAB15476" /db_xref="GOA:O06979" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12406" /db_xref="UniProtKB/Swiss-Prot:O06979" /translation="MLKTYLIDRLAIILFSLLGIGSAMLIAYLSIVESGAEPSKENMM YIWILPGTLLAAGFAADYVRQFSFLTYVKKLAEQASSSNDIGQSLKARKPRTGEQALW TKMINALGQQYESRLSQYINQQKQHYTFTNQWVHHMKTPVSVISLMIQEGKNGTSSSF PTFLEELEDENERFRHGLDMMLQTARLEEFAFDVKPQTFDLAEMVRSLINQEKRQFIK RRLFPTLHVPPNAVQISSDQKWLSFVVEQILFNALKYSKQGVGDPITIRIETQGHETR LSVADEGIGIPPQDLPRIFDAFFTGENGRTMKEATGMGLYLAKQVCSRLGHKLYAESK EGAGTVMTIVFSSDTLVNVTAL*" /label="psdS CDS" gene complement(3041030..3042100) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /label="psdS gene" CDS complement(3042094..3042807) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [PsdS] responding to lipid II-binding lantibiotics (nisin and gallidermin)" /protein_id="NP_391352.1" /db_xref="EnsemblGenomes-Gn:BSU34720" /db_xref="EnsemblGenomes-Tr:CAB15477" /db_xref="GOA:O06978" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12405" /db_xref="UniProtKB/Swiss-Prot:O06978" /translation="MYRILLVEDDERIASLLGGHLQKYGYEVKIAEQLNDIKLEFAEM KPDLVLLDINLPFFDGFYWCRQIRTISNAPIIFISARTDELNQVMAIENGGDDYITKP FHLEVVMAKIKSVLRRTYGEYSPSLPQESRIVELGGLTIYPDQNEAEWNSVRILFSQK EFQLLSIFVREHKKIVSRDELLEALWDDVDFVDDNTLTVNVNRLRRKLENAGLTDCIS TIRGQGYQFQVNRKDEAEC*" /label="psdR CDS" gene complement(3042094..3042807) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /label="psdR gene" promotor_-10 complement(3042853..3042872) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3042865) /Source="Nicolas_upshifts" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3042867..3043128) /Source="Nicolas_S_feature" /locus_tag="new_3568195_3568456_c" /HighExp="H2O2, G135, G180, Cold, Paraq, G150, dia15, Oxctl, LBGexp, C30" /AntisenseName="yvzJ" /AntisenseCor="0.56014644713727801" /AntisenseRegPval="-22.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1322" promotor_-35 complement(3042885..3042888) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3042888..3042895 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3042906..3042925 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3042911 /Source="Nicolas_upshifts" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 3042954..3043163 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="YP_003097790.1" /db_xref="EnsemblGenomes-Gn:BSU34729" /db_xref="EnsemblGenomes-Tr:CAX52696" /db_xref="GOA:C0H3R7" /db_xref="UniProtKB/Swiss-Prot:C0H3R7" /translation="MKKIMLFLAMTSILSACQPNYTGKYIEIGDTLTDYTKECFKENE IPYKYEKGKLYIPEDAFDTAIYTCS*" /label="yvzJ CDS" gene 3042954..3043163 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /label="yvzJ gene" downshifts 3043141 /Source="Nicolas_upshifts" /id="D1798" /incds=0 /nref=7 /ntot=138 /MaxReadThrough="1.16039" /MaxDrop="3.61604" /score="-5.58790836" /energy="-11.4" /TU="NA" /idTUdmin="U2726" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3043173) /Source="Nicolas_upshifts" /id="D1799" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="3.16808" /MaxDrop="2.84175" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(3043199..3043963) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10876241; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative arylamine N-acetyltransferase" /protein_id="NP_391353.1" /db_xref="EnsemblGenomes-Gn:BSU34730" /db_xref="EnsemblGenomes-Tr:CAB15478" /db_xref="GOA:O06977" /db_xref="InterPro:IPR001447" /db_xref="SubtiList:BG12404" /db_xref="UniProtKB/Swiss-Prot:O06977" /translation="MIKMSDFLKDCFQKIGWEKDHVSFGDLPLFLKAMAYRFPFENRA VLAKENYKITKEELWRRLLKDQHGGLCYDLNGFLYFVLREAGFHVKLIRGTVYAGDQE GWALEGTHAAVWLSAENGDYLVDIGFGINLALQPIPLSGETVQSPVGSFRIKKEETEK GSYVLLMDKGEGWQIGYAFTLEESDLGDLDNMKDIIHSHEKSPFNKSLLASKLTPSGR MVMSERHFTIYENGGNIQKSDIGPSGFEEKLNTHFL*" /label="yvcN CDS" gene complement(3043199..3043963) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /label="yvcN gene" downshifts complement(3043221) /Source="Nicolas_upshifts" /id="D1800" /incds=0 /nref=143 /ntot=253 /MaxReadThrough="3.19848" /MaxDrop="6.45069" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3043964..3044221) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="catabolite repression HPr-like protein" /protein_id="NP_391354.1" /db_xref="EnsemblGenomes-Gn:BSU34740" /db_xref="EnsemblGenomes-Tr:CAB15479" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1K1C" /db_xref="PDB:1MO1" /db_xref="PDB:1MU4" /db_xref="PDB:1ZVV" /db_xref="PDB:2AK7" /db_xref="PDB:2RLZ" /db_xref="SubtiList:BG12403" /db_xref="UniProtKB/Swiss-Prot:O06976" /translation="MVQQKVEVRLKTGLQARPAALFVQEANRFTSDVFLEKDGKKVNA KSIMGLMSLAVSTGTEVTLIAQGEDEQEALEKLAAYVQEEV*" /label="crh CDS" gene complement(3043964..3044221) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /label="crh gene" CDS complement(3044245..3045195) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10986251, 17603302, 19836336, 24097947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative morphogen" /protein_id="NP_391355.1" /db_xref="EnsemblGenomes-Gn:BSU34750" /db_xref="EnsemblGenomes-Tr:CAB15480" /db_xref="GOA:O06975" /db_xref="InterPro:IPR003802" /db_xref="InterPro:IPR018478" /db_xref="InterPro:IPR023054" /db_xref="InterPro:IPR027434" /db_xref="InterPro:IPR033981" /db_xref="SubtiList:BG12402" /db_xref="UniProtKB/Swiss-Prot:O06975" /translation="MSFASETKKELTNLEVKDCCINAELSALIRMNGALSFTNRHLVL DVQTENAAIARRIYTLLKKQYDVSVELLVRKKMRLKKNNVYIVRFSENAKAILEDLKI LGENFVFERSISKELVKKRCCKRSYMRGAFLAGGSVNNPETSSYHLEIFSLYKEHNDS LCDLLNEFQLNSKTLERKKGYITYLKEAEKITEFLNVIGAHNSLLRFEDVRIVRDMRN SVNRLVNCETANLNKTIGASLRQVENIKYIDERIGLEALPEKLREIAQLRIDYQEVTL KELGEMVASGKISKSGINHRLRKLDEIAEQLRTGQTVTLK*" /label="whiA CDS" gene complement(3044245..3045195) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /label="whiA gene" CDS complement(3045218..3046171) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159; Product type f: factor" /codon_start=1 /transl_table=11 /product="gluconeogenesis morphogenetic factor (UDP-sugar binding)" /protein_id="NP_391356.2" /db_xref="EnsemblGenomes-Gn:BSU34760" /db_xref="EnsemblGenomes-Tr:CAB15481" /db_xref="GOA:O06974" /db_xref="InterPro:IPR002882" /db_xref="InterPro:IPR010119" /db_xref="SubtiList:BG12401" /db_xref="UniProtKB/Swiss-Prot:O06974" /translation="MGQKPKIAIFGGGTGLSVLLRGLKHKPVDITAIVTVADDGGSSG RLRNELKIPPPGDIRNVLAALSDVEPLVEDLFQHRFNKGNDLTGHSLGNLILAAMTNI TGDFFHAVTEMSKVLNVRGKVLPAANASVVLHAEMEDGRVVSGESTIPEYGQRIKRVF LTPEQIDPLPETIDVIREADLIIIGPGSLYTSILPNLLVPKIGEEVIKAPAKKVYICN VMTQPGETLHYTAADHVKALNQHMGCGFIDTILVNSEDIPDEIKRKYEMESARPVDFD IEELKAMGLEVIRDQIVTYKNDVIRHDTHKVASLLVDLLKE*" /label="mgfK CDS" gene complement(3045218..3046171) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /label="mgfK gene" CDS complement(3046173..3047060) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /function="15.6: DNA transformation" /experiment="publication(s) with functional evidences, PMID:18334534, 19074378, 21179021, 21709426" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18334534, 19074378, 21179021, 21709426; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase possibly involved in regulator sRNA degradation" /protein_id="NP_391357.1" /db_xref="EnsemblGenomes-Gn:BSU34770" /db_xref="EnsemblGenomes-Tr:CAB15482" /db_xref="GOA:O06973" /db_xref="InterPro:IPR005337" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12400" /db_xref="UniProtKB/Swiss-Prot:O06973" /translation="MSVSESHDIQLVIITGMSGAGKTVAIQSFEDLGYFCVDNLPPSL LPKFLELMKESNSKMSKVALVMDLRGREFFDRLIEALDEMAENPWITPRILFLDAKDS ILVTRYKETRRSHPLAATGLPLEGIALERELLEELKGRSQIIYDTSDMKPRDLREKIV KHFATNQGETFTVNVMSFGFKYGIPIDADLVFDVRFLPNPYYIESMRPLTGKDKEVSS YVMKWNETQKFNEKLIDLLSFMLPSYKREGKSQVVIAIGCTGGQHRSVTLAENLADYF KKDYYTHVTHRDIEKRSRK*" /label="yvcJ CDS" gene complement(3046173..3047060) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /label="yvcJ gene" CDS complement(3047085..3047561) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /EC_number="3.6.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative triphosphate pyrophosphate hydrolase" /protein_id="NP_391358.1" /db_xref="EnsemblGenomes-Gn:BSU34780" /db_xref="EnsemblGenomes-Tr:CAB15483" /db_xref="GOA:O06972" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG12399" /db_xref="UniProtKB/Swiss-Prot:O06972" /translation="MTYLQRVTNCVLQTDDKVLLLQKPRRGWWVAPGGKMESGESVRD SVIREYREETGIYIINPQLKGVFTFIIKDGDHIVSEWMMFTFVADSYTGQNVSESEEG KLQWHDVNDIQNLPMAPGDGHILDFMMKGQGLLHGTFTYTPEFELLSYRLDPQHIK*" /label="yvcI CDS" gene complement(3047085..3047561) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /label="yvcI gene" promotor_-10 complement(3047581..3047600) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3047595) /Source="Nicolas_upshifts" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3047616..3047620) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3047639..3047658) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3047652) /Source="Nicolas_upshifts" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3047673..3047676) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3047728..3047878) /Source="Nicolas_S_feature" /locus_tag="new_3573056_3573206_c" /HighExp="dia15, Diami, dia5, H2O2, Etha, LPhT, Cold, Paraq, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1323" downshifts complement(3047771) /Source="Nicolas_upshifts" /id="D1801" /incds=0 /nref=9 /ntot=78 /MaxReadThrough="6.94979" /MaxDrop="3.73811" /score="11.9453839" /energy="-11" /TU="U2729,U2733" /idTUdmin="U2734" /TUdmin=2904 /isTUend="FALSE" /label="downshifts" CDS complement(3047879..3048829) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /EC_number="1.8.1.9" /function="16.6: Maintain" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14597697, 15659166, 23813734, 24401092" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14597697, 15659166, 23813734, 24401092; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin reductase" /protein_id="NP_391359.1" /db_xref="EnsemblGenomes-Gn:BSU34790" /db_xref="EnsemblGenomes-Tr:CAB15484" /db_xref="GOA:P80880" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR005982" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12398" /db_xref="UniProtKB/Swiss-Prot:P80880" /translation="MSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMIERGIPGGQM ANTEDVENYPGFESILGPELSNKMFEHAKKFGAEYAYGDIKEVIDGKEYKVVKAGSKE YKARAVIIAAGAEYKKIGVPGEKELGGRGVSYCAVCDGAFFKGKELVVVGGGDSAVEE GVYLTRFASKVTIVHRRDKLRAQSILQARAFDNEKVDFLWNKTVKEIHEENGKVGNVT LVDTVTGEESEFKTDGVFIYIGMLPLSKPFENLGITNEEGYIETNDRMETKVEGIFAA GDIREKSLRQIVTATGDGSIAAQSVQHYVEELQETLKTLK*" /label="trxB CDS" gene complement(3047879..3048829) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /label="trxB gene" S_feature complement(3048830..3048917) /Source="Nicolas_S_feature" /locus_tag="new_3574158_3574245_c" /HighExp="dia5, Diami, dia15, H2O2, Etha, Salt, Cold, Paraq, LPhT, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1324" promotor_-10 complement(3048906..3048925) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3048917) /Source="Nicolas_upshifts" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3048919..3049010) /Source="Nicolas_S_feature" /locus_tag="new_3574247_3574338_c" /HighExp="Cold, Oxctl, G180, G135, Paraq, C30, LBGexp, G150, S1, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1325" promotor_-35 complement(3048940..3048943) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3048958..3048964 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3048978..3048996 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3048992 /Source="Nicolas_upshifts" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="upshifts" S_feature 3048993..3052379 /Source="Nicolas_S_feature" /locus_tag="new_3574321_3577707" /HighExp="Sw, M9-stat, B60, T0.30H, Gly, BC, B36, T1.0H, Salt, C30" /AntisenseName="yvcD" /AntisenseCor="-0.261780844003138" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1326" CDS complement(3049035..3050456) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /EC_number="3.4.-.-" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted cell wall DL-endopeptidase" /protein_id="NP_391360.1" /db_xref="EnsemblGenomes-Gn:BSU34800" /db_xref="EnsemblGenomes-Tr:CAB15485" /db_xref="GOA:P40767" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG11023" /db_xref="UniProtKB/Swiss-Prot:P40767" /translation="MRKSLITLGLASVIGTSSFLIPFTSKTASAETLDEKKQKIESKQ SEVASSIEAKEKELTELQENQSKIEKELKDINDKALDTSNKIEDKKEENDKTKEEIKK LKKEIKETEARIEKRNEILKKRVRSLQESGGSQGYIDVLLGSTSFGDFISRATAVSSI VDADKDLIKQQEQDKAKLEDSEADLNDKLKEVQAALAKLETMQKDLDKQLNEKDKLFD EAKASQKKTAKAISELKSEASELANQKANTEAEQARIKKEQEAAAALIKKQEEAQKAS DETQTDDSQTATTESSKASSSDDSSDNSSDNSSNGSSNSSSNGSSSKKSSGSNSNSGG TVISNSGGIEGAISVGSSIVGQSPYKFGGGRTQSDINNRIFDCSSFVRWAYASAGVNL GPVGGTTTDTLVGRGQAVSASEMKRGDLVFFDTYKTNGHVGIYLGNGTFLNDNTSHGV SVDSMSNPYWKAAFKGVVRRVVQ*" /label="cwlO CDS" gene complement(3049035..3050456) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /label="cwlO gene" downshifts complement(3049055) /Source="Nicolas_upshifts" /id="D1802" /incds=0 /nref=8 /ntot=106 /MaxReadThrough="6.31311" /MaxDrop="3.4602" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1620 /isTUend="FALSE" /label="downshifts" downshifts complement(3049179) /Source="Nicolas_upshifts" /id="D1803" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="7.07718" /MaxDrop="2.13349" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" misc_feature 3050083..3050087 /Source="Nicolas_upshift_promotors" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3050093 /Source="Nicolas_upshifts" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3050372..3050376 /Source="Nicolas_upshift_promotors" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3050379 /Source="Nicolas_upshifts" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3050457..3050654) /Source="Nicolas_S_feature" /locus_tag="new_3575785_3575982_c" /HighExp="S1, Cold, T-3.40H, M9-exp, MG t5, MG 5, MG 15, T-5.40H, GM-0.2, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1327" downshifts 3050577 /Source="Nicolas_upshifts" /id="D1804" /incds=0 /nref=2 /ntot=119 /MaxReadThrough="6.41604" /MaxDrop="3.8522" /score="6.14322693" /energy="-7.6" /TU="U2730,U2731" /idTUdmin="U2731" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3050642..3050661) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-10" upshifts complement(3050654) /Source="Nicolas_upshifts" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" promotor_-35 complement(3050673..3050680) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-35" CDS complement(3050837..3052291) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391361.1" /db_xref="EnsemblGenomes-Gn:BSU34810" /db_xref="EnsemblGenomes-Tr:CAB15486" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12396" /db_xref="UniProtKB/Swiss-Prot:O06968" /translation="MGKHTSEHKNHAQIVQLLQDGQYFFHKGLKAYKERNLKRASKLI QRAVHLEPEDSEMLSQLAVIYSEMGQYQESNDLLDYIMANLEAEMPECHYFKANNFAH LGLFQEAYKEAAAYSDADPDGEFAEENDSLLDLLDLGDDGIEDSLYDQDELLVKQDRA KSLLESGQLAEAVAALEEITTEYPELWSAYNNLALAYFYSGNVVKAKQTAYEVLSHNE GNLHALCNLLVFYYYEREDEKVAELSDQLSNVYPMLLEQRYKLGATLALVGRYEIGYK WLKSLYKTGFEGDDTFFYWLSCSAYFTGHTDFAETIWRKVESQYPGEDRPAPWIERRE ALPSSVEQRLAAYYISSTKGETEHLEAVIRSKRITAPFETHFVKLLLNGDSAAADVSE DALFAYQTVKLLEQAEKEEMKTEVMSCWVFHVIQQIRAAAPLKNEKGWAAAICYIWKE AHGKQDTKKDTAARFGISPATLTKYMKYIDDILE*" /label="yvcD CDS" gene complement(3050837..3052291) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /label="yvcD gene" downshifts complement(3050857) /Source="Nicolas_upshifts" /id="D1805" /incds=0 /nref=11 /ntot=190 /MaxReadThrough="3.36188" /MaxDrop="3.98985" /score="16.3455178" /energy="-9.1" /TU="U2734" /idTUdmin="U2734" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" S_feature complement(3052292..3052416) /Source="Nicolas_S_feature" /locus_tag="new_3577620_3577744_c" /HighExp="LBGstat, Sw, Cold, BC, BI, Lbexp, dia0, G150, LBGtran, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1328" downshifts 3052337 /Source="Nicolas_upshifts" /id="D1806" /incds=0 /nref=4 /ntot=36 /MaxReadThrough="1.81602" /MaxDrop="3.41181" /score="7.59889121" /energy="-9.9" /TU="NA" /idTUdmin="U2730" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3052417..3054186) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16405427, 18215075, 21077936, 22711831, 24630999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16405427, 18215075, 21077936, 22711831, 24630999; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (ATP-binding and permease protein)" /protein_id="NP_391362.1" /db_xref="EnsemblGenomes-Gn:BSU34820" /db_xref="EnsemblGenomes-Tr:CAB15487" /db_xref="GOA:O06967" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12395" /db_xref="UniProtKB/Swiss-Prot:O06967" /translation="MPTKKQKSKSKLKPFFALVRRTNPSYGKLAFALALSVVTTLVSL LIPLLTKQLVDGFSMSNLSGTQIGLIALVFFVQAGLSAYATYALNYNGQKIISGLREL LWKKLIKLPVSYFDTNASGETVSRVTNDTMVVKELITTHISGFITGIISVIGSLTILF IMNWKLTLLVLVVVPLAALILVPIGRKMFSISRETQDETARFTGLLNQILPEIRLVKA SNAEDVEYGRGKMGISSLFKLGVREAKVQSLVGPLISLVLMAALVAVIGYGGMQVSSG ELTAGALVAFILYLFQIIMPMGQITTFFTQLQKSIGATERMIEILAEEEEDTVTGKQI ENAHLPIQLDRVSFGYKPDQLILKEVSAVIEAGKVTAIVGPSGGGKTTLFKLLERFYS PTAGTIRLGDEPVDTYSLESWREHIGYVSQESPLMSGTIRENICYGLERDVTDAEIEK AAEMAYALNFIKELPNQFDTEVGERGIMLSGGQRQRIAIARALLRNPSILMLDEATSS LDSQSEKSVQQALEVLMEGRTTIVIAHRLSTVVDADQLLFVEKGEITGRGTHHELMAS HGLYRDFAEQQLKMNADLENKAG*" /label="bmrA CDS" gene complement(3052417..3054186) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /label="bmrA gene" S_feature complement(3054187..3054261) /Source="Nicolas_S_feature" /locus_tag="new_3579515_3579589_c" /HighExp="LBGstat, Cold, Lbexp, G150, Oxctl, dia0, T1.30H, T0.30H, BC, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1329" misc_feature complement(3054250..3054269) /Source="Nicolas_upshift_promotors" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3054261) /Source="Nicolas_upshifts" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" CDS complement(3054351..3054710) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391363.1" /db_xref="EnsemblGenomes-Gn:BSU34830" /db_xref="EnsemblGenomes-Tr:CAB15488" /db_xref="SubtiList:BG14157" /db_xref="UniProtKB/Swiss-Prot:O32265" /translation="MTSLFSESETEIVSTTYMFLTQDEMKGKAGTLNQPINDFLSLTK KFESSLKEEIKGQKGLIVKKIKKELESNSEKRKAALQMIKEEHTAKVDRYKMIIEDLR QQDVTLTYRKKKPVKDV*" /label="yvzA CDS" gene complement(3054351..3054710) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /label="yvzA gene" downshifts complement(3054371) /Source="Nicolas_upshifts" /id="D1807" /incds=0 /nref=146 /ntot=246 /MaxReadThrough="2.52417" /MaxDrop="4.81771" /score="18.5636016" /energy="-13.2" /TU="NA" /idTUdmin="U2735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3054725..3056635) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391364.1" /db_xref="EnsemblGenomes-Gn:BSU34840" /db_xref="EnsemblGenomes-Tr:CAB15489" /db_xref="SubtiList:BG12394" /db_xref="UniProtKB/Swiss-Prot:O06966" /translation="MGNKNVFENENVKLRLIDLEYDYKQKFASTIASEVKKAKKDFEA DIRRIYKEETHHDLPENMKIEIYTSNELVNQNTSIQSSTRESGYDGTAIHIIDEKKHI DQLQIISEGSADNKDWSYNFFGLFLGIDHSQYEATKEFTNKAKKAAGNSEDLKTFALG HSLANNNQVMVQLIDGEYDEVYGVNGAQVNIDQLLETDESLYRYVIRKFSYKYEDIDS IPPEKLKKEIQKYYEDKGVTTNITQRISKDDPLYGVSGKADFITFGDVKMADTNTSVK GIRNIMDGVPDEDVRSIQKFLQKYKDDYEKDGLNGFIKAASGIDIDLIEKVKNTDGAL KKVSVLYEHFDDVKQMYGRIKEELPSFLGFLHTLLRNSGPVVDQLAENGYIDETQKKV IKKELTNINASMRGIESRYEHFIDHLKHGQFMQALKDVGEIVDYVKSILSSLKTLDTE TKDALKLIVDGHSIVQMLNALSKEKGFSYKGSDIYFTGKSGSGETIQVNLSSAVRIYQ NGMKIVEDMEDAISKYQKVYSQEIDEDFIDKKQAIITAIHHMEENPSHYAFDLQFRLA AGFSHTFDKLEKISVHESFHTGALPANDGIVAELKKQTTEKRDFIKNIRESIEKLFEK EEMISQLFDFQS*" /label="yvcB CDS" gene complement(3054725..3056635) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /label="yvcB gene" CDS complement(3056637..3057362) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17590234; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391365.1" /db_xref="EnsemblGenomes-Gn:BSU34850" /db_xref="EnsemblGenomes-Tr:CAB15490" /db_xref="GOA:O06965" /db_xref="SubtiList:BG12393" /db_xref="UniProtKB/Swiss-Prot:O06965" /translation="MKKIIFICFSLLLALTGGCSMNDNDKNSTNDNKTEAVKPKDMDP KDLPQVPAFQDEKTREYMVSTKEEEPGYYLLESKLKGFRMLFPEDGKYLSRRSSLTGK NKESIGFNSYDKDTNVMFDGHVTYYKEESFANEPKTMLDIVSGKNDYKGEYKKSSKKK TDIYTAKKKDIFDDIDRKYNYSYSYFGYVKSTEEDNLGVEYAFTLGCKNENQPCSLDE EKAKNKVEKLINSITFLIDKKEK*" /label="yvcA CDS" gene complement(3056637..3057362) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /label="yvcA gene" S_feature complement(3057363..3057451) /Source="Nicolas_S_feature" /locus_tag="new_3582691_3582779_c" /HighExp="T1.30H, T0.30H, T1.0H, T2.0H, T2.30H, T3.0H, T-1.40H, T-1.10H, MG 150, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1330" promotor_-10 complement(3057451..3057470) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3057451) /Source="Nicolas_upshifts" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3057453..3057582) /Source="Nicolas_S_feature" /locus_tag="new_3582781_3582910_c" /HighExp="Etha, Diami, HiTm, T1.0H, Cold, MG 15, T0.30H, BMM, T1.30H, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1331" promotor_-35 complement(3057486..3057489) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3057608..3058237) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /EC_number="3.5.4.19" /EC_number="3.6.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15871048, 17767732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase" /protein_id="NP_391366.1" /db_xref="EnsemblGenomes-Gn:BSU34860" /db_xref="EnsemblGenomes-Tr:CAB15491" /db_xref="GOA:O34912" /db_xref="InterPro:IPR002496" /db_xref="InterPro:IPR008179" /db_xref="InterPro:IPR021130" /db_xref="InterPro:IPR023019" /db_xref="InterPro:IPR026660" /db_xref="SubtiList:BG12603" /db_xref="UniProtKB/Swiss-Prot:O34912" /translation="MKQADELRFNEDGLIPAIVQDAASKEVLTLAYMNKESYEKTLET KETWFYSRSRQALWHKGETSGNTQAVKGIRYDCDQDALLVLVEPSGPACHTGSYSCFT KEQTEEQAADRFGIMNELERVIAERQAEMPEGAYTTYLFREGVDKILKKVGEEASEVI IAAKNRDHEELKWEAADLLYHLLVLLREQSLPLDDVLDVLKKRHSEIEE*" /label="hisIE CDS" gene complement(3057608..3058237) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /label="hisIE gene" downshifts complement(3057627) /Source="Nicolas_upshifts" /id="D1808" /incds=0 /nref=104 /ntot=178 /MaxReadThrough="4.37156" /MaxDrop="4.76747" /score="14.9565762" /energy="-8.4" /TU="U2738" /idTUdmin="U2735" /TUdmin="-3256" /isTUend="FALSE" /label="downshifts" CDS complement(3058234..3058992) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /EC_number="4.3.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 17767732, 19636909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase subunit" /protein_id="NP_391367.1" /db_xref="EnsemblGenomes-Gn:BSU34870" /db_xref="EnsemblGenomes-Tr:CAB15492" /db_xref="GOA:O34727" /db_xref="InterPro:IPR004651" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12600" /db_xref="UniProtKB/Swiss-Prot:O34727" /translation="MITKRIIPCLDVKEGRVVKGIQFLELKDAGDPVELAEVYDREGA DELVFLDISASHEGRKTMVDVVEQVAAKLAIPFTVGGGINQLSDMKTILRAGADKVSV NTAAVLRPELITEGAEFFGSQCIVLAIDAKYDKESDTYKVYTHGGRKKTDWEVTAWAK EGVKRGAGEILLTSMDSDGEKKGFDHTLTKLVSEAVPVPVIASGGAGNAQHMLEAFTK GEADAALAASIFHYKETSIKEVKSYLKEYGVNVR*" /label="hisF CDS" gene complement(3058234..3058992) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /label="hisF gene" CDS complement(3058989..3059726) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /EC_number="5.3.1.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 26294764; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase" /protein_id="NP_391368.1" /db_xref="EnsemblGenomes-Gn:BSU34880" /db_xref="EnsemblGenomes-Tr:CAB15493" /db_xref="GOA:O35006" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR006063" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023016" /db_xref="SubtiList:BG12597" /db_xref="UniProtKB/Swiss-Prot:O35006" /translation="MSAFTLYPAIDMRNGKCVRLVQGDYNKETIYGDSPYDMAELFEK EGAEWIHLVDLDGAKEGKRVNDRHVIEIAQKLNLKVEIGGGIRSENDVYEYLSAGVER VILGSSAVSNPPFVKKMLKQYGEKIAIGLDARNGFVSTEGWLETSTLKATELGKELAN EGAEVFIFTDIATDGMLSGPNVKSTVELAKETGKSVIASGGVSSVADLEALARNEADG VSGAIIGKALYTNQFTLSEALERVKRK*" /label="hisA CDS" gene complement(3058989..3059726) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /label="hisA gene" CDS complement(3059723..3060361) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /EC_number="2.4.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 15301532" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 15301532; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase, glutamineamidotransferase subunit" /protein_id="NP_391369.1" /db_xref="EnsemblGenomes-Gn:BSU34890" /db_xref="EnsemblGenomes-Tr:CAB15494" /db_xref="GOA:O34565" /db_xref="InterPro:IPR010139" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12602" /db_xref="UniProtKB/Swiss-Prot:O34565" /translation="MIGVIDYGMGNLYSVSKALERVGVPYFVSEKPEELKEADAFILP GVGSFGDAMDNLGYTKLDQLIHDMVSEGRLLLGICLGMQLLFEESEENGTASGLGLLK GKAVRLKAEDEKGNKLKVPHMGWNRLSFHNESPLLTKTEQGYAYFVHSYYIDGMEENA LLASADYGVRVPAVVGKRNVFGAQFHPEKSSTVGMSILTQFTKMAAEQKVKK*" /label="hisH CDS" gene complement(3059723..3060361) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /label="hisH gene" promotor_no_box 3060219..3060319 /Source="Nicolas_upshift_promotors" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3060279 /Source="Nicolas_upshifts" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3060362..3060946) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /EC_number="4.2.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 24311587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazoleglycerol-phosphate dehydratase [Mn(II)-dependent]" /protein_id="NP_391370.1" /db_xref="EnsemblGenomes-Gn:BSU34900" /db_xref="EnsemblGenomes-Tr:CAB15495" /db_xref="GOA:O34683" /db_xref="InterPro:IPR000807" /db_xref="InterPro:IPR020565" /db_xref="InterPro:IPR020568" /db_xref="SubtiList:BG12598" /db_xref="UniProtKB/Swiss-Prot:O34683" /translation="MRKAERVRKTNETDIELAFTIDGGGQADIKTDVPFMTHMLDLFT KHGQFDLSINAKGDVDIDDHHTTEDIGICLGQALLEALGDKKGIKRYGSAFVPMDEAL AQVVIDLSNRPHLEMRADFPAAKVGTFDTELVHEFLWKLALEARMNLHVIVHYGTNTH HMIEAVFKALGRALDEATTIDPRVKGIPSTKGML*" /label="hisB CDS" gene complement(3060362..3060946) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /label="hisB gene" CDS complement(3060943..3062226) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /EC_number="1.1.1.23" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10353847, 10353848, 21672513, 24140957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol dehydrogenase" /protein_id="NP_391371.1" /db_xref="EnsemblGenomes-Gn:BSU34910" /db_xref="EnsemblGenomes-Tr:CAB15496" /db_xref="GOA:O34651" /db_xref="InterPro:IPR001692" /db_xref="InterPro:IPR012131" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR022695" /db_xref="SubtiList:BG12599" /db_xref="UniProtKB/Swiss-Prot:O34651" /translation="MKIKTISGAERLSLKRSIDAGTEEQRKTVRSIIEDVKANGDQAV RSYTAKFDCIEIDSPLVTKEEFEEAYTSLDSRLLQVIRQAIENIREYHERQLQSSWFY HRKDGTMLGQKVTALDSAGVYVPGGTAAYPSSVLMNVIPALVAGVERIVLVTPPGKDG LLSPGVLVAAAELGIKDIYKMGGAQAIAALAYGTETIEPVDKITGPGNIYVALAKREV FGDVDIDMIAGPSEIVVLADETAIPSEIAADLLSQAEHDKLSSCVFVTDSMALAETVS AEVNKQLETLPRREIAEASVRDYGCIYVAETMVEAIETVNTLAPEHLEIITQSPEALL GSIKHAGAIFLGRYSPEPVGDYFAGPNHVLPTNGTARFSSPLNVTDFQKKSSIISYSQ SAFEEHAESIAAFARLEGLEAHARSIEARERRISK*" /label="hisD CDS" gene complement(3060943..3062226) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /label="hisD gene" CDS complement(3062223..3062864) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /EC_number="2.4.2.17" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 14741209, 15660995, 17154531, 21774583, 22989207, 28092443, 28872824; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP phosphoribosyltransferase" /protein_id="NP_391372.1" /db_xref="EnsemblGenomes-Gn:BSU34920" /db_xref="EnsemblGenomes-Tr:CAB15497" /db_xref="GOA:O34520" /db_xref="InterPro:IPR001348" /db_xref="InterPro:IPR013820" /db_xref="InterPro:IPR018198" /db_xref="InterPro:IPR024893" /db_xref="PDB:2VD2" /db_xref="SubtiList:BG12601" /db_xref="UniProtKB/Swiss-Prot:O34520" /translation="MGKLLTMAMPKGRIFEEAAGLLRQAGYRLPEEFEDSRKLIIDVP EENLRFILAKPMDVTTYVEHGVADVGIAGKDVMLEEERDVYEVLDLNISKCHLAVAGL PNTDWSGVAPRIATKYPNVASSYFREQGEQVEIIKLNGSIELAPLIGLADRIVDIVST GQTLKENGLVETEHICDITSRFIVNPVSYRMKDDVIDEMASRLSLVVEGETAK*" /label="hisG CDS" gene complement(3062223..3062864) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /label="hisG gene" CDS complement(3062857..3064032) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /EC_number="2.4.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 15660995; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase-like subunit of ATP phophoribosyltransferase" /protein_id="NP_391373.1" /db_xref="EnsemblGenomes-Gn:BSU34930" /db_xref="EnsemblGenomes-Tr:CAB15498" /db_xref="GOA:O34459" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR004517" /db_xref="InterPro:IPR006195" /db_xref="SubtiList:BG12606" /db_xref="UniProtKB/Swiss-Prot:O34459" /translation="MFMFEKPHGMRDTLPGLYETKKKVRRSLTDLIDKWGYQFMETPT LEFYDTVGVQSAIEEQQLFKLLDQDGKTLVLRPDMTGPIARVAASKLLKHGHPLRVGY AANVFRAQEREGGRPAEFEQVGVELIGDGTTSADAEVIALVVGALKNAGLASFKIAIG HAGIADALFVEVLGNVERADVLRRFLYEKNYVGYREHVKSLPLSSIDKSRLLELLELR GGIEVCGRAEEIVDSAQGKSVVDELKALWDILEDYGCTENVRLDLNMVSHMSYYTGIL FEVYAENVGFVIGSGGRYNKLLGHFDSPAPATGFGLRIDRLIEALHMKDEPCEIDAVI FSKEQRAQAIAYANEERMKGNKVVLQDLSGIENIDQMTKSFANVTYFIGARKEEQNG* " /label="hisZ CDS" gene complement(3062857..3064032) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /label="hisZ gene" S_feature complement(3064033..3064110) /Source="Nicolas_S_feature" /locus_tag="new_3589361_3589438_c" /HighExp="Diami, M/G, Etha, BMM, MG 15, MG 10, T-1.10H, T-0.40H, T-1.40H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1332" promotor_-35 3064076..3064082 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3064094..3064113 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3064094..3064113) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3064107 /Source="Nicolas_upshifts" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3064110) /Source="Nicolas_upshifts" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3064126..3064133) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3064242..3064261 /Source="Nicolas_upshift_promotors" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3064249 /Source="Nicolas_upshifts" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="upshifts" CDS 3064283..3065035 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydratase" /protein_id="NP_391374.1" /db_xref="EnsemblGenomes-Gn:BSU34940" /db_xref="EnsemblGenomes-Tr:CAB15499" /db_xref="InterPro:IPR016997" /db_xref="SubtiList:BG14130" /db_xref="UniProtKB/Swiss-Prot:O34735" /translation="MKTLRTLCVLMILSGVIFFGLKIDAKDIDIPFLNSLKKVVSDSD TDSAANSKKELKGSAKPLDVILYNQMDAPRLYNGCEVTSLAMVLNYAGYDVTKNTLAN QVATVPLTYSSGLKGDPNDGFVGDMANGPGLGVYHRPIYQLAKTYAGDKVSDLTGKSI SAVYQQLEKGNPVWVITTANFTPVDNMQTWKTPNGTIEITYSEHSVAVTGYDDKYVYL NDPYGYKNRKTDRTSFEKAWKQMGSQAVVIQK*" /label="yvpB CDS" gene 3064283..3065035 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /label="yvpB gene" S_feature 3065036..3065274 /Source="Nicolas_S_feature" /locus_tag="new_3590364_3590602" /HighExp="LBGstat, LPhT, Cold, Sw, M/G, G180, G135, LBGtran, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1333" promotor_-10 complement(3065057..3065068) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3065063) /Source="Nicolas_upshifts" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3065083..3065089) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3065275..3065940 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658655, 15187182, 16514142, 20000851, 24236123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658655, 15187182, 16514142, 20000851, 24236123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted pectate (polygalacturonate) lyase" /protein_id="NP_391375.1" /db_xref="EnsemblGenomes-Gn:BSU34950" /db_xref="EnsemblGenomes-Tr:CAB15500" /db_xref="GOA:O34310" /db_xref="InterPro:IPR004898" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG14129" /db_xref="UniProtKB/Swiss-Prot:O34310" /translation="MKKIVSILFMFGLVMGFSQFQPSTVFAADKVVHETIIVPKNTTY DGKGQRFVAGKELGDGSQSENQDPVFRVEDGATLKNVVLGAPAADGVHTYGNVNIQNV KWEDVGEDALTVKKEGKVTIDGGSAQKASDKIFQINKASTFTVKNFTADNGGKFIRQL GGSTFHVDVIIDKCTITNMKEAIFRTDSKTSTVRMTNTRYSNVGQKWIGVQHIYENNN TQF*" /label="pelC CDS" gene 3065275..3065940 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /label="pelC gene" downshifts 3065911 /Source="Nicolas_upshifts" /id="D1809" /incds=0 /nref=85 /ntot=213 /MaxReadThrough="1.40389" /MaxDrop="4.93342" /score="16.0973385" /energy="-14.9" /TU="NA" /idTUdmin="U2739" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(3065960..3066478) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21761520, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21761520, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphorylated heptaprenylglyceryl phosphate O-acetyltransferase" /protein_id="NP_391376.1" /db_xref="EnsemblGenomes-Gn:BSU34960" /db_xref="EnsemblGenomes-Tr:CAB15501" /db_xref="GOA:O34993" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG14128" /db_xref="UniProtKB/Swiss-Prot:O34993" /translation="MRKTDRHPVSGANSLWHVYQTVPFLKVVKNFIVIQIARYTPFIG MKNWLYRTFLRMKVGKQTSFALMVMPDIMFPEKISVGTNTIIGYNTTILAHEYLIHEY RIGKVLIGDEVMIGANTTILPGVKIGDGAVVSAGTLVHKDVPDGAFVGGNPMRIIYTK EEMQERLKKSAE*" /label="hprF CDS" gene complement(3065960..3066478) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /label="hprF gene" downshifts complement(3065994) /Source="Nicolas_upshifts" /id="D1810" /incds=0 /nref=245 /ntot=283 /MaxReadThrough="1.27998" /MaxDrop="6.44997" /score="38.2106579" /energy="-14.9" /TU="NA" /idTUdmin="U2741" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3066482..3067132) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /EC_number="3.6.1.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9465101, 12359880, 12411438, 16182622, 22353596" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9465101, 12359880, 12411438, 16182622, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Hpr-associated pyrophosphatase" /protein_id="NP_391377.1" /db_xref="EnsemblGenomes-Gn:BSU34970" /db_xref="EnsemblGenomes-Tr:CAB15502" /db_xref="GOA:Q9JMQ2" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023733" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14127" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ2" /translation="MSDKQVTTILFDLDGTLINTNELIIASFLHTLEHYYPSKYKRED VLAFIGPSLFDTFSSMDPDKCEDMIAMYRAYNHDMHDSLVTEYETVYETLDALKKAGF TLGIVTTKLRDTVNMGLKLTGIGEFFETVVTLDDVTNAKPDPEPVLLALKQLGSEPAE AIMVGDNYHDVLAGKNAGTKTAGVAWTIKGPEMLAKHEPDFMLEKMSDLLQIVGVK*" /label="ppaX CDS" gene complement(3066482..3067132) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /label="ppaX gene" CDS complement(3067129..3068067) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27226549; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with nucleotide binding domain" /protein_id="NP_391378.1" /db_xref="EnsemblGenomes-Gn:BSU34980" /db_xref="EnsemblGenomes-Tr:CAB15503" /db_xref="GOA:O34382" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG14126" /db_xref="UniProtKB/Swiss-Prot:O34382" /translation="MKKIFLAGLAAGFQTTWTLGKVIFPVTLLVTLLQHTPVMDWLVR LITPVMGLFGLSGEAAIPLVLGNMLNLYAGIAGILTLDLSVKEVFILAVMLSFCHNLI IESTVAAKVGIRIGVILAVRIGLAAVSAIVINLIWHGGKETAQYGFIAAKSAAPDSWL GMLAEALTKAGLGVLQLAAIVIPLMIIIQFLRDLGWLYRFSRWLSPFTQLLGMNKNTS MTMVTGLTIGLAYGAGVMIKAVEDDGVSKRDMTLAFIFLVACHAVVEDTLVFIPLGIP VWPLLLIRVTTAVLLTMAIAHTWKKWKPSAVGKEAI*" /label="yvoD CDS" gene complement(3067129..3068067) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /label="yvoD gene" CDS complement(3068091..3068900) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /EC_number="2.4.99.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prelipoprotein diacylglycerol transferase" /protein_id="NP_391379.1" /db_xref="EnsemblGenomes-Gn:BSU34990" /db_xref="EnsemblGenomes-Tr:CAB15504" /db_xref="GOA:O34752" /db_xref="InterPro:IPR001640" /db_xref="SubtiList:BG12611" /db_xref="UniProtKB/Swiss-Prot:O34752" /translation="MNEAIEPLNPIAFQLGPLAVHWYGIIIGLGALLGLWIAMRESEK RGLQKDTFIDLVLFAIPIAIICARIYYVAFEWDYYAAHPGEIIKIWKGGIAIHGGLIG AILTGYVFSRVKNLSFWKLADIAAPSILLGQAIGRWGNFMNQEAHGEAVSRAFLENLH LPEFIINQMYINGQYYHPTFLYESLWSFVGVIVLLLLRRANLRRGEMFLIYIIWYSIG RYFIEGMRTDSLMLTDSLRIAQVISIVLIVLAVAAIIFRRVKGYSKERYAE*" /label="lgt CDS" gene complement(3068091..3068900) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /label="lgt gene" CDS complement(3068914..3069846) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /EC_number="2.7.4.-" /EC_number="2.7.11.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine protein kinase/phosphorylase (pyrophosphate-producing)" /protein_id="NP_391380.1" /db_xref="EnsemblGenomes-Gn:BSU35000" /db_xref="EnsemblGenomes-Tr:CAB15505" /db_xref="GOA:O34483" /db_xref="InterPro:IPR003755" /db_xref="InterPro:IPR011104" /db_xref="InterPro:IPR011126" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG14125" /db_xref="UniProtKB/Swiss-Prot:O34483" /translation="MAKVRTKDVMEQFNLELISGEEGINRPITMSDLSRPGIEIAGYF TYYPRERVQLLGKTELSFFEQLPEEEKKQRMDSLCTDVTPAIILSRDMPIPQELIDAS EKNGVPVLRSPLKTTRLSSRLTNFLESRLAPTTAIHGVLVDIYGVGVLITGKSGVGKS ETALELVKRGHRLVADDCVEIRQEDQDTLVGNAPELIEHLLEIRGLGIINVMTLFGAG AVRSNKRITIVMNLELWEQGKQYDRLGLEEETMKIIDTEITKLTIPVRPGRNLAVIIE VAAMNFRLKRMGLNAAEQFTNKLADVIEDGEQEE*" /label="hprK CDS" gene complement(3068914..3069846) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /label="hprK gene" promotor_-10 complement(3069888..3069907) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3069894) /Source="Nicolas_upshifts" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3069923..3069928) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3069963..3069970 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3069982 /Source="Nicolas_upshifts" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3069985..3070002 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3070028..3071218 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /EC_number="3.5.1.25" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6774970, 14557261, 21602348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6774970, 14557261, 21602348; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosamine-6-phosphate deacetylase" /protein_id="NP_391381.1" /db_xref="EnsemblGenomes-Gn:BSU35010" /db_xref="EnsemblGenomes-Tr:CAB15506" /db_xref="GOA:O34450" /db_xref="InterPro:IPR003764" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2VHL" /db_xref="SubtiList:BG12630" /db_xref="UniProtKB/Swiss-Prot:O34450" /translation="MAESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYS KEIQAPADSVLLPGMIDIHIHGGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQ EHGNISQALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVEL FKKWQQEAGGLIKIVTLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAGA SHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSKL ILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMNEGARHMREFTNC SWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVILTICRGNIAFISKE ADQI*" /label="nagA CDS" gene 3070028..3071218 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /label="nagA gene" promotor_-35 3071016..3071022 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3071037 /Source="Nicolas_upshifts" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3071038..3071056 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3071215..3071943 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /EC_number="3.5.99.6" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15755726, 18436239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 18436239; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate isomerase" /protein_id="NP_391382.1" /db_xref="EnsemblGenomes-Gn:BSU35020" /db_xref="EnsemblGenomes-Tr:CAB15507" /db_xref="GOA:O35000" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="PDB:2BKV" /db_xref="PDB:2BKX" /db_xref="SubtiList:BG12631" /db_xref="UniProtKB/Swiss-Prot:O35000" /translation="MKVMECQTYEELSQIAARITADTIKEKPDAVLGLATGGTPEGTY RQLIRLHQTENLSFQNITTVNLDEYAGLSSDDPNSYHFYMNDRFFQHIDSKPSRHFIP NGNADDLEAECRRYEQLVDSLGDTDIQLLGIGRNGHIGFNEPGTSFKSRTHVVTLNEQ TRQANARYFPSIDSVPKKALTMGIQTILSSKRILLLISGKSKAEAVRKLLEGNISEDF PASALHLHSDVTVLIDREAASLRP*" /label="nagBA CDS" gene 3071215..3071943 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /label="nagBA gene" CDS 3071961..3072692 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /experiment="publication(s) with functional evidences, PMID:16207374, 20047956, 21602348, 23667565, 24673833, 26162881" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 20047956, 21602348, 23667565, 24673833, 26162881; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_391383.1" /db_xref="EnsemblGenomes-Gn:BSU35030" /db_xref="EnsemblGenomes-Tr:CAB15508" /db_xref="GOA:O34817" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2WV0" /db_xref="PDB:4U0V" /db_xref="PDB:4U0W" /db_xref="PDB:4U0Y" /db_xref="PDB:4WWC" /db_xref="SubtiList:BG14124" /db_xref="UniProtKB/Swiss-Prot:O34817" /translation="MNINKQSPIPIYYQIMEQLKTQIKNGELQPDMPLPSEREYAEQF GISRMTVRQALSNLVNEGLLYRLKGRGTFVSKPKMEQALQGLTSFTEDMKSRGMTPGS RLIDYQLIDSTEELAAILGCGHPSSIHKITRVRLANDIPMAIESSHIPFELAGELNES HFQSSIYDHIERYNSIPISRAKQELEPSAATTEEANILGIQKGAPVLLIKRTTYLQNG TAFEHAKSVYRGDRYTFVHYMDRLS*" /label="nagR CDS" gene 3071961..3072692 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /label="nagR gene" CDS complement(3072712..3076581) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_391384.1" /db_xref="EnsemblGenomes-Gn:BSU35040" /db_xref="EnsemblGenomes-Tr:CAB15509" /db_xref="GOA:O34986" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR011401" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036415" /db_xref="SubtiList:BG14123" /db_xref="UniProtKB/Swiss-Prot:O34986" /translation="MRKYTVIASILLSFLSVLSGGHHESKAFPVVQQELFQTPHYIPL LENPPQIDVKAEMRSNLMIEAQVRDNSYQAFSAFLFYKQSNELGYKMVPMDPTPGAVR KFLAQIPKRLIWNSELEYYIVMSNGKQRVESETKKLKLEGYQADLAHIPELLITELAV DTKNIGRADGYEFIEIFNTTDRTIDFKDYHIRYRYPKEGPDSDLIWRPDERILIPSGE TFVVWLKPAGHPELTSADFNRYYQTQLKEGKNLAVIDETEGMANTRPRAVVISTNTGK DISVAHYRKHALRRLSSVLYKYPLNGTAELLNISIGEKNPSPGTVLQAQVPDQKRKIK LDKEKPVIEDLTDRKPVRPAESIELRADIRDRSLVKTVAFYYRTDENKPFKRILAEKD RNDNLFHYIVYSPELIGKDQLEYYVAAGDGINEARTPVKMIDIKQTSKAHGLRMNIEN RDTLSGTQFLKATTEGRADSIKLWIDGKKQVTEPAMEKEVYFAFDTRKTNLYFKNAVT MEGKVLKVFDDTTNKYRTYSVPLPETLLRKGKQLQRITIRSGSKVSPFDTAENRDDFL VKNARLVLSDGTVIRDQRVSPEKELFIGDNQRSNKSWQFQFNLPDGLFTSQLLEWDTS KLSEGAHHIQASDGKENVSLVVRVDNSGPHIEPNITEGQTYKGNLILQADMYDKWSRI EEAEASLDGESITLPYHTSSSDLLPGKHSLKVTATDLAGNKTVIERIFKTEREHPDQP EVIDSEADTHKAKLSVRVKDPTNDAMDVGFYRGFQYTARNHVKIFKHASLTEPPKSFV PERETPFTNKELERVSAADGKTVSTENKELFPYHRFEVTVDPSIDENDLAESVWKGSS LPGRKVTMYAWNYRTNEWQPVDSFVAKDDKPFTLKASVIAADFVRESKMNVIVQDEIP PAKDMYTFVWMSDTQYYAESYPHIFDKQTEWIKDNQKQLNIKYVFHTGDIVDDSADIR QWKNADRSMSVLDKSGIPYGVLAGNHDVGHKDGSYRAFGKYFGSDRFDKKFHYGGSYK NNRGHYDLISSNGNDYIMLYMGWGITDEDIAWMNQVLKKHPDRMAILAFHEYLLVSGN RSPIGEKIFKEIVKPNPNVVMVLSGHYHSAMRKTDELDDDGDGKPDRLVHQMLADYQG GPEGGQGYLRLLQFDQANDMVHVSTYSPYVKDKNYYDTDTYGNKDEFSLSLDLKPRIK KVETDYFECNVYTNEELGKREQVKSGDTAEFRWDHLEPQSVYYWYIIVEDSFNGKTKS PIWKFKTKKETYRPAPDQFDFRHVSNP*" /label="yvnB CDS" gene complement(3072712..3076581) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /label="yvnB gene" downshifts complement(3072834) /Source="Nicolas_upshifts" /id="D1811" /incds=1 /nref=19 /ntot=109 /MaxReadThrough="1.28942" /MaxDrop="4.39575" /score="28.0438848" /energy="-16.5" /TU="NA" /idTUdmin="U2744" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3076601..3076612) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3076608) /Source="Nicolas_upshifts" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3076627..3076633) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3076671..3076677 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3076691..3076710 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3076696 /Source="Nicolas_upshifts" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="upshifts" CDS 3076746..3077219 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391385.1" /db_xref="EnsemblGenomes-Gn:BSU35050" /db_xref="EnsemblGenomes-Tr:CAB15510" /db_xref="GOA:O34692" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14122" /db_xref="UniProtKB/Swiss-Prot:O34692" /translation="MDNSIHDELFQAIQQFALKRDKRVWQKVQIPSIGISSQHHDHLK KDWTLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNK KEIFYTLTDSGRKLAALHEQLHEKAKEQYKQLFNEFSIDDLKTVTAFFNLWIKYM*" /label="yvnA CDS" gene 3076746..3077219 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /label="yvnA gene" S_feature 3077220..3077327 /Source="Nicolas_S_feature" /locus_tag="new_3602548_3602655" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, T2.30H, M9-stat, T2.0H, T1.30H, T1.0H, BC" /AntisenseName="cypX" /AntisenseCor="-1.1473096183385199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1334" CDS complement(3077260..3078477) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /EC_number="1.14.-.-" /function="16.5: Explore" /function="16.14: Store" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:4204912, 20690619, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 20690619, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclo-L-leucyl-L-leucyl dipeptide oxidase, pulcheriminic synthase" /protein_id="NP_391386.1" /db_xref="EnsemblGenomes-Gn:BSU35060" /db_xref="EnsemblGenomes-Tr:CAB15511" /db_xref="GOA:O34926" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR030904" /db_xref="InterPro:IPR036396" /db_xref="PDB:3NC3" /db_xref="PDB:3NC5" /db_xref="PDB:3NC6" /db_xref="PDB:3NC7" /db_xref="SubtiList:BG12580" /db_xref="UniProtKB/Swiss-Prot:O34926" /translation="MSQSIKLFSVLSDQFQNNPYAYFSQLREEDPVHYEESIDSYFIS RYHDVRYILQHPDIFTTKSLVERAEPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALD HLSPLIKQNAENLLAPYLERGKSDLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSG VADFITSISQSPEARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMAL SDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDVLADRSLVPRAIAETLRY KPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIK SAFSGAARHLAFGSGIHNCVGAAFAKNEIEIVANIVLDKMRNIRLEEDFCYAESGLYT RGPVSLLVAFDGA*" /label="cypX CDS" gene complement(3077260..3078477) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /label="cypX gene" downshifts complement(3077273) /Source="Nicolas_upshifts" /id="D1812" /incds=0 /nref=11 /ntot=50 /MaxReadThrough="2.27112" /MaxDrop="6.67384" /score="-0.264310319" /energy="-11.6" /TU="NA" /idTUdmin="U2747" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3077299..3077304 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3077319..3077330 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3077329..3077614 /Source="Nicolas_S_feature" /locus_tag="new_3602657_3602942" /HighExp="BC, Sw, Lbstat, T5.0H, M9-stat, T4.0H, T3.30H, B60, T1.30H, T0.30H" /AntisenseName="cypX" /AntisenseCor="-4.04991056466339E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.438, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1335" upshifts 3077329 /Source="Nicolas_upshifts" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="upshifts" downshifts 3077571 /Source="Nicolas_upshifts" /id="D1813" /incds=1 /nref=9 /ntot=165 /MaxReadThrough="3.27492" /MaxDrop="3.99509" /score="54.0406126" /energy="-11.4" /TU="U2745,U2746" /idTUdmin="U2746" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3078493..3079239) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /EC_number="6.-.-.-" /function="16.14: Store" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:4204912, 19430487, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 19430487, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclodipeptide synthase (tRNA-dependent), pulcherimminic acid precursor" /protein_id="NP_391387.1" /db_xref="EnsemblGenomes-Gn:BSU35070" /db_xref="EnsemblGenomes-Tr:CAB15512" /db_xref="GOA:O34351" /db_xref="InterPro:IPR030903" /db_xref="SubtiList:BG14121" /db_xref="UniProtKB/Swiss-Prot:O34351" /translation="MTGMVTERRSVHFIAEALTENCREIFERRRHVLVGISPFNSRFS EDYIYRLIGWAKAQFKSVSVLLAGHEAANLLEALGTPRGKAERKVRKEVSRNRRFAER ALVAHGGDPKAIHTFSDFIDNKAYQLLRQEVEHAFFEQPHFRHACLDMSREAIIGRAR GVSLMMEEVSEDMLNLAVEYVIAELPFFIGAPDILEVEETLLAYHRPWKLGEKISNHE FSICMRPNQGYLIVQEMAQMLSEKRITSEG*" /label="pchC CDS" gene complement(3078493..3079239) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /label="pchC gene" S_feature complement(3079240..3079426) /Source="Nicolas_S_feature" /locus_tag="new_3604568_3604754_c" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T3.0H, T1.0H, B36, BT, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1336" promotor_-10 complement(3079412..3079431) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3079426) /Source="Nicolas_upshifts" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3079445..3079452) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3079560..3079567 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3079582..3079601 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3079594 /Source="Nicolas_upshifts" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="upshifts" S_feature 3079595..3079664 /Source="Nicolas_S_feature" /locus_tag="new_3604923_3604992" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T1.0H, T0.30H, B36, T3.0H, BT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1337" CDS 3079665..3080174 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27542896; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for pulcherriminic acid synthesis" /protein_id="NP_391388.1" /db_xref="EnsemblGenomes-Gn:BSU35080" /db_xref="EnsemblGenomes-Tr:CAB15513" /db_xref="GOA:P40762" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11018" /db_xref="UniProtKB/Swiss-Prot:P40762" /translation="MSDLTKQMIYDIYVRLLHLNEQKANTSLQQFFKEAAEEDVAEIP KNMTSIHVIDCIGQHEPINNAGIARKMNLSKANVTKISTKLIKEEFINSYQLTDNKKE VYFKLTRKGRRIFDLHEKLHKKKELAFYQFLDSFSQEEQKAVLKFLEQLTSTLEAEQT DGTPDKPVK*" /label="pchR CDS" gene 3079665..3080174 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /label="pchR gene" S_feature complement(3080070..3081408) /Source="Nicolas_S_feature" /locus_tag="new_3605398_3606736_c" /HighExp="T0.30H, T1.0H, T1.30H, T-0.40H, T0.0H, T2.0H, G135, T2.30H, T-1.10H, G180" /AntisenseName="yvmA" /AntisenseCor="0.2423954904641" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1338" downshifts complement(3080111) /Source="Nicolas_upshifts" /id="D1814" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.42525" /MaxDrop="2.72496" /score="14.1278884" /energy="-7.8" /TU="NA" /idTUdmin="U2749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3080195..3081406 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27542896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pulcherriminic acid efflux transporter" /protein_id="NP_391389.1" /db_xref="EnsemblGenomes-Gn:BSU35090" /db_xref="EnsemblGenomes-Tr:CAB15514" /db_xref="GOA:O34307" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14120" /db_xref="UniProtKB/Swiss-Prot:O34307" /translation="MAHTKSKAVLILYTVCFSAFFASLSQNIYSPILPIIKESFHVST AMVNLSVSVFMIVTAIMQIILGAIIDFKGARIVLITGILATAAASIGCAVTTDFTLFL IFRMIQAAGSAALPLIAATTIGQLFTGNERGSAMGTYQMLLSVAPAIAPVLGGFIGGA AGYEGIFWILAAISIVLLVTNSITFPKDSPTESMQQAKGNVFAHYKSIFTNRTGNVIL TLSFVLFFIYFAVIVYLPILLTEHYHIDVGIAGLLYLPLALSTIAGTFLFKRIQAKIG LHTLFIGSNVIAACSIILFAVTHSVSLVLMALTLALFGISMGVIPPLYSTMITNEFEH NRGSAIGMFNFIRYTGMAAGPMVSAYLLTMMPSAMSFSLLGLGFAALSFCLLPPMFSP QKRTKQKKHHM*" /label="pchE CDS" gene 3080195..3081406 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /label="pchE gene" downshifts 3081404 /Source="Nicolas_upshifts" /id="D1815" /incds=0 /nref=33 /ntot=196 /MaxReadThrough="5.27186" /MaxDrop="4.73361" /score="54.0406126" /energy="-11.4" /TU="U2748" /idTUdmin="U2748" /TUdmin="-721" /isTUend="FALSE" /label="downshifts" CDS complement(3081434..3081793) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26296725; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral phage holin-like membrane protein" /protein_id="NP_391390.1" /db_xref="EnsemblGenomes-Gn:BSU35100" /db_xref="EnsemblGenomes-Tr:CAB15515" /db_xref="GOA:O34648" /db_xref="InterPro:IPR007165" /db_xref="SubtiList:BG14119" /db_xref="UniProtKB/Swiss-Prot:O34648" /translation="MVKWAVSILVNALLLIVIDGYIDSIHISSIGAAIIASLILSILN VLIKPLLIIFTLPVTMVTLGLFLFVINAITLMMTASIMGDSFQIDGFGTAIWASVILS VFHLLIQKGILEPLRKK*" /label="yvlD CDS" gene complement(3081434..3081793) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /label="yvlD gene" S_feature 3081449..3082165 /Source="Nicolas_S_feature" /locus_tag="new_3606777_3607493" /HighExp="LBGstat, S8, Gly, C30, G135, S7, C90, Sw, Fru, S6" /AntisenseName="yvlC" /AntisenseCor="0.178445666283919" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1339" downshifts complement(3081453) /Source="Nicolas_upshifts" /id="D1816" /incds=0 /nref=129 /ntot=265 /MaxReadThrough="4.63835" /MaxDrop="5.15146" /score="14.4434545" /energy="-9.6" /TU="U2749" /idTUdmin="U2751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3081795..3081992) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23980836; Product type r : regulator" /codon_start=1 /transl_table=11 /product="membrane associated phage-like stress regulator,nisin resistance" /protein_id="NP_391391.1" /db_xref="EnsemblGenomes-Gn:BSU35110" /db_xref="EnsemblGenomes-Tr:CAB15516" /db_xref="GOA:O34719" /db_xref="InterPro:IPR007168" /db_xref="SubtiList:BG14118" /db_xref="UniProtKB/Swiss-Prot:O34719" /translation="MNKLYRSEKNKKIAGVIGGLAEYFNWDASLLRVITVILAIMTSV LPVLLIYIIWIFIVPSERDMK*" /label="yvlC CDS" gene complement(3081795..3081992) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /label="yvlC gene" CDS complement(3081997..3083094) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function, stress-related" /protein_id="NP_391392.1" /db_xref="EnsemblGenomes-Gn:BSU35120" /db_xref="EnsemblGenomes-Tr:CAB15517" /db_xref="InterPro:IPR016599" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14117" /db_xref="UniProtKB/Swiss-Prot:O34628" /translation="MKQEKERILKLVEEGKLTAQEALTLIEKLDSDYKEKEEKITALS VHVHDEEEPFTTAKKESGKPSLGAKLFDWIDSAVKKVKEVDLDLNFGHAYDVQHIFQF KDTDFSSVELQIANGSVNIVPWEDDDIRAECQAKVYRADSQDAARHAFLQHIECEIKG NKFFIRTEKKTMKTNVTLYIPQKEYDKIRVKLFNGPVRGEHLHVKEFSAKTTNGVLSF SYLTAEKAIAETANGQIKLASHSCGTIEAETINGLIDLRGKSESIDVQSFNGNIAINV TESDCRSIYAKTTTGNVELAIPDDLAVKAELKSNLGTLSHELMDVEMLKEKNDTIQKE MMFTSNQAHDQNITVFSESLTGAIKLKYSQR*" /label="yvlB CDS" gene complement(3081997..3083094) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /label="yvlB gene" CDS complement(3083119..3083445) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391393.1" /db_xref="EnsemblGenomes-Gn:BSU35130" /db_xref="EnsemblGenomes-Tr:CAB15518" /db_xref="GOA:O34322" /db_xref="SubtiList:BG14116" /db_xref="UniProtKB/Swiss-Prot:O34322" /translation="MNRNQAIIASLCYFSVFIAPIIVPIVAYFVVNEKETKRHAIRSL ISHIVPFVGWLFLFIALLGGAVAIDGDSLLPVFVIIGGAVIYFLVVIGIIIWNVIQGI KVLRAA*" /label="yvlA CDS" gene complement(3083119..3083445) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /label="yvlA gene" promotor_-10 complement(3083498..3083513) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3083513) /Source="Nicolas_upshifts" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3083515..3084005) /Source="Nicolas_S_feature" /locus_tag="new_3608843_3609333_c" /HighExp="H2O2, G180, Paraq, G150, G135, dia15, Oxctl, Diami, Lbexp, LBGexp" /AntisenseName="yvkN" /AntisenseCor="0.37678416921083902" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1340" promotor_-35 complement(3083525..3083534) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3083593..3083596 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3083611..3083630 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3083621 /Source="Nicolas_upshifts" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="upshifts" CDS 3083663..3083893 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391394.1" /db_xref="EnsemblGenomes-Gn:BSU35140" /db_xref="EnsemblGenomes-Tr:CAB15519" /db_xref="SubtiList:BG14115" /db_xref="UniProtKB/Swiss-Prot:O34604" /translation="MEKDPSDYTVTQESVLKLIQEQKRMNREMITELEQIHGPFPISH DIQYIKVLLDSSNTHIVQDLMSVSKQLYKKTL*" /label="yvkN CDS" gene 3083663..3083893 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /label="yvkN gene" promotor_-10 complement(3083996..3084015) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-10" upshifts complement(3084006) /Source="Nicolas_upshifts" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="upshifts" promotor_-35 complement(3084031..3084035) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-35" CDS complement(3084092..3084574) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16936039; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="putative flagellin" /db_xref="EnsemblGenomes-Gn:BSU35150" /db_xref="EnsemblGenomes-Tr:CAB15520" /db_xref="GOA:O34366" /db_xref="InterPro:IPR001029" /db_xref="PSEUDO:CAB15520.1" /db_xref="SubtiList:BG14158" /db_xref="UniProtKB/Swiss-Prot:O34366" /translation="MDALIEEVDGISNRTEFNGKKLLDGTETDGFTFQIGANAGQQLT VNIDSMSSTALGVNALNVTDFANTPFDTQLESIDTAINNVSNQRAKLGAVQNRLEHTI NNLGASSENLTAAESRIRDVDMAKEMSEFTKNNIPSQASQAMLAQANQQPQNVLQLLR *" /label="yvzB CDS" gene complement(3084092..3084574) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /pseudo /label="yvzB gene" downshifts 3084100 /Source="Nicolas_upshifts" /id="D1817" /incds=0 /nref=13 /ntot=113 /MaxReadThrough="0.9814" /MaxDrop="4.76969" /score="2.6592903" /energy="-5.7" /TU="NA" /idTUdmin="U2750" /TUdmin=17 /isTUend="TRUE" /label="downshifts" downshifts complement(3084115) /Source="Nicolas_upshifts" /id="D1818" /incds=0 /nref=118 /ntot=206 /MaxReadThrough="2.62918" /MaxDrop="8.97968" /score="25.6132739" /energy="-19.8" /TU="NA" /idTUdmin="U2752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3084247) /Source="Nicolas_upshifts" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3084255..3084258) /Source="Nicolas_upshift_promotors" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3084335..3084339) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3084335) /Source="Nicolas_upshifts" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3084355..3084358) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3084575..3084708) /Source="Nicolas_S_feature" /locus_tag="new_3609903_3610036_c" /HighExp="H2O2, Sw, M40t45, M40t90, Diami, Salt, dia15, BC, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1341" CDS complement(3084736..3087609) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit A)" /protein_id="NP_391396.1" /db_xref="EnsemblGenomes-Gn:BSU35160" /db_xref="EnsemblGenomes-Tr:CAB15533" /db_xref="GOA:O34863" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004602" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12697" /db_xref="UniProtKB/Swiss-Prot:O34863" /translation="MAMDRIEVKGARAHNLKNIDVTIPRDQLVVVTGLSGSGKSSLAF DTIYAEGQRRYVESLSAYARQFLGQMDKPDVDAIEGLSPAISIDQKTTSRNPRSTVGT VTEIYDYLRLLYARVGKPHCPEHGIEITSQTIEQMVDRILEYPERTKLQVLAPIVSGR KGAHVKVLEQIRKQGYVRVRIDGEMAELSDDIELEKNKKHSIEVVIDRIVVKEGVAAR LSDSLETALRLGEGRVMIDVIGEEELMFSEHHACPHCGFSIGELEPRLFSFNSPFGAC PTCDGLGMKLEVDADLVIPNQDLSLKENAVAPWTPISSQYYPQLLEAVCTHYGIDMDV PVKDLPKHQLDKVLYGSGDDLIYFRYENDFGQIREGEIQFEGVLRNIERRYKETGSDF IREQMEQYMSQKSCPTCKGYRLKKEALAVLIDGRHIGKITELSVADALAFFKDLTLSE KDMQIANLILREIVERLSFLDKVGLDYLTLSRAAGTLSGGEAQRIRLATQIGSRLSGV LYILDEPSIGLHQRDNDRLISALKNMRDLGNTLIVVEHDEDTMMAADYLIDIGPGAGI HGGQVISAGTPEEVMEDPNSLTGSYLSGKKFIPLPPERRKPDGRYIEIKGASENNLKK VNAKFPLGTFTAVTGVSGSGKSTLVNEILHKALAQKLHKAKAKPGSHKEIKGLDHLDK VIDIDQAPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKVRGYKKGRFSFNVKGGRCEA CRGDGIIKIEMHFLPDVYVPCEVCHGKRYNRETLEVTYKGKSISDVLDMTVEDALSFF ENIPKIKRKLQTLYDVGLGYITLGQPATTLSGGEAQRVKLASELHKRSTGRTLYILDE PTTGLHVDDIARLLVVLQRLVDNGDTVLVIEHNLDIIKTADYIVDLGPEGGAGGGTIV ASGTPEEITEVEESYTGRYLKPVIERDKTRMKSLLKAKETATS*" /label="uvrA CDS" gene complement(3084736..3087609) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /label="uvrA gene" downshifts complement(3084753) /Source="Nicolas_upshifts" /id="D1819" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="4.46283" /MaxDrop="5.3695" /score="12.0157254" /energy="-18.6" /TU="U2754,U2756" /idTUdmin="U2755" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3087617..3089602) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit B)" /protein_id="NP_391397.1" /db_xref="EnsemblGenomes-Gn:BSU35170" /db_xref="EnsemblGenomes-Tr:CAB15534" /db_xref="GOA:P37954" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004807" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR024759" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036876" /db_xref="PDB:2D7D" /db_xref="PDB:2NMV" /db_xref="PDB:3V4R" /db_xref="SubtiList:BG10502" /db_xref="UniProtKB/Swiss-Prot:P37954" /translation="MKDRFELVSKYQPQGDQPKAIEKLVKGIQEGKKHQTLLGATGTG KTFTVSNLIKEVNKPTLVIAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYV PQTDTFIEKDASINDEIDKLRHSATSALFERRDVIIIASVSCIYGLGSPEEYREMVVS LRTEMEIERNELLRKLVDIQYARNDIDFQRGTFRVRGDVVEIFPASRDEHCVRVEFFG DEIERIREVDALTGEILGDRDHVAIFPASHFVTRAEKMEKAIQNIEKELEEQLKVMHE NGKLLEAQRLEQRTRYDLEMMREMGFCSGIENYSRHLTLRPPGSTPYTLLDYFPDDFM IVVDESHVTIPQVRGMFNGDQARKQVLVDHGFRLPSALDNRPLRFEEFEKHMHNIVYV SATPGPYEIEHTDEMVEQIIRPTGLLDPLIDVRPIEGQIDDLIGEIQARIERNERVLV TTLTKKMSEDLTDYLKEIGIKVNYLHSEIKTLERIEIIRDLRLGKYDVLVGINLLREG LDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNAEGRVIMYADKITKSMEIAINE TKRRREQQERFNEEHGITPKTINKEIRDVIRATVAAEDKAEYKTKAAPKLSKMTKKER QKVVEQMEHEMKEAAKALDFERAAELRDLLLELKAEG*" /label="uvrB CDS" gene complement(3087617..3089602) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /label="uvrB gene" promotor_-10 complement(3089636..3089655) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3089648) /Source="Nicolas_upshifts" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3089650..3089735) /Source="Nicolas_S_feature" /locus_tag="new_3614978_3615063_c" /HighExp="Gly, Sw, B60, BT, LoTm, Salt, Etha, M9-stat, B36, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1342" promotor_-35 complement(3089667..3089674) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3089780) /Source="Nicolas_upshifts" /id="D1820" /incds=0 /nref=4 /ntot=60 /MaxReadThrough="5.68784" /MaxDrop="3.17938" /score="11.285993" /energy="-12" /TU="U2755,U2756" /idTUdmin="U2755" /TUdmin="-5027" /isTUend="FALSE" /label="downshifts" CDS complement(3089788..3090018) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 1592822, 1744042; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_391398.1" /db_xref="EnsemblGenomes-Gn:BSU35180" /db_xref="EnsemblGenomes-Tr:CAB15535" /db_xref="GOA:P37953" /db_xref="InterPro:IPR019242" /db_xref="SubtiList:BG10501" /db_xref="UniProtKB/Swiss-Prot:P37953" /translation="MITKAVFALFFPFMLVVLFTRVTFNHYVAIALTAALLFASYLKG YTETYFIVGLDVVSLVAGGLYMAKKAAEKKEE*" /label="csbA CDS" gene complement(3089788..3090018) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /label="csbA gene" promotor_-10 complement(3090045..3090064) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-10" upshifts complement(3090055) /Source="Nicolas_upshifts" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="upshifts" S_feature complement(3090057..3090121) /Source="Nicolas_S_feature" /locus_tag="new_3615385_3615449_c" /HighExp="Gly, M9-stat, B60, Sw, Etha, LoTm, BT, B36, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1343" promotor_-35 complement(3090078..3090085) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-35" promotor_-10 complement(3090098..3090116) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3090119) /Source="Nicolas_upshifts" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3090131..3090137) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3090187) /Source="Nicolas_upshifts" /id="D1821" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.9693" /MaxDrop="4.37808" /score="-1.92287727" /energy="-4.2" /TU="NA" /idTUdmin="U2761" /TUdmin=4752 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(3090213..3090313) /Source="Nicolas_upshift_promotors" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3090253) /Source="Nicolas_upshifts" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3090335..3090342 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3090356..3090375 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3090373 /Source="Nicolas_upshifts" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3090465..3092960 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /EC_number="2.7.-.-" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25012659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_391399.1" /db_xref="EnsemblGenomes-Gn:BSU35190" /db_xref="EnsemblGenomes-Tr:CAB15536" /db_xref="GOA:O34796" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG14114" /db_xref="UniProtKB/Swiss-Prot:O34796" /translation="MYSVLFRQAEESSQLAGAKGMNLIKLTKHGLPVPDGFIIQTNAL ARFMEDNQLQETSENVEGGIISGTFSDELKDELTSSFYKLRESYRSVAVRSSSASEDL EGASFAGQYETYLNIKTEEEFLAKVKECWASFFSGRVSSYKKKMNNQIAEPLMGIVVQ GLIDSEMSGVIFSRNPVTHDDRELLISASYGLGEAVVSGNVTPDTFIVNKSSFEIQKE IGAKEIYMESAAEGIAEKETSEDMRSRFCLTDEQVIELAEITKKTEDLYGYPVDIEFG IADHQIYLLQARPITTIDQDKKAAEEKRSFMITDTDMNDFWLNMESNIEGPVSPLFSS FIVPALEYGLKKSMQKFPIGVVVDEVKLYRGHIYSKNQGGQQPPSEDCGKELFPILSE HMYDIINHTYLPFYRTLDQLAQTEHTAESALEAFQKLKAFYLTAYEEHFNIVFPQILL TNKLQAMYQDIQGESENAHFYEMLTGKMNKSLETDRCLWLFSVEVQENPNLLAIFENN KPEQLQEKLEQTDEGRHFLKNVHEFLQEYGWRSVKSHDLIEQIWVENPYFALANIQNY VRNGYHFDNEFQKTKEKREKLYNEFLESIEDPGLRTEFDRYYQWTLNSANIKDDHHFY IDAMLDAKARIFLLKIGELLAENGVIQDREDLWFLYDDEVEQALLHPVSLQEKAEKRR QIFHEYELAQAPAYLGTPTKEQLKAAEEIVGAVIEDEKNTENHIFGIAASSGIATGPV KIIRDANEFSQFAPGDVLVCKMTTPLWTSLFQDAKAIITDTGGILSHAAIIAREYGIP AVLGTRTATERLRDGDIITVDGSSGKITVVSRS*" /label="yvkC CDS" gene 3090465..3092960 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /label="yvkC gene" misc_feature 3092975..3092979 /Source="Nicolas_upshift_promotors" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3092993 /Source="Nicolas_upshifts" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="upshifts" CDS 3093036..3093605 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391400.1" /db_xref="EnsemblGenomes-Gn:BSU35200" /db_xref="EnsemblGenomes-Tr:CAB15537" /db_xref="GOA:O34643" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG14113" /db_xref="UniProtKB/Swiss-Prot:O34643" /translation="MRPTNKRILDAAMQLLVKKGYRATTTKEIAEKANVSEATIFRNF KNKQGLVEALLSQHSSNRGSILEQTEGDLYKDLLHIGTCLLEELEHRKDIIKISFREP AMFQDVINHVTEYPQSMKQLLVDYLKTMGEKGVIQTGNEAEHADVFMSIIFGYFIHRL HLGDRVISMPQEKMLEHSTALFVKGISAD*" /label="yvkB CDS" gene 3093036..3093605 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /label="yvkB gene" CDS 3093636..3094970 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391401.1" /db_xref="EnsemblGenomes-Gn:BSU35210" /db_xref="EnsemblGenomes-Tr:CAB15538" /db_xref="GOA:O34502" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14112" /db_xref="UniProtKB/Swiss-Prot:O34502" /translation="MSSRKEWALIVSLLLGAILVPINSTMIAVALSSISHTYNESIAS ITWVVTVYLIVMAVTQPIAGKLGDMYGNKTMYLWGVGLFLIASLGCALSPSLLLLIVF RALQAVGGALLTPNSIAIIRHVVSEKRLPKVFGFFGLGAGLGAALGPFIGSILIDSFS WHSIFWVNIPFLAIALFTALTMFPQYKENKSDAPLDIIGSLLLAGSIVSIILLTKNEA PWGYTVYSVLILLFVPLFFRREKRTQHPIIDFALFKSSTFTNANLSVLLSNLMMYAVL LIMPLFMTNQFGLNTSNSGMALSVFSIFMSASNWVGAQLHHKWGAKKIIFLSFAMMAG ANLLFLLLSSSHSVLFLMLSLILGGLASGVGLTSMQVSSLATVDPGMSGVASGIFSTF RYFGSIISSALIGLISGYHTLFMILFAVSIIGVFVSLGIKSDETARIEKNSA*" /label="yvkA CDS" gene 3093636..3094970 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /label="yvkA gene" downshifts 3094951 /Source="Nicolas_upshifts" /id="D1822" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="0.94661" /MaxDrop="3.57731" /score="21.0606505" /energy="-28.8" /TU="NA" /idTUdmin="U2759" /TUdmin=1276 /isTUend="FALSE" /label="downshifts" CDS complement(3095018..3096211) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16030230, 16850406, 18976281, 19019154, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16030230, 16850406, 18976281, 19019154, 26735940; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="topological determinant of cell division" /protein_id="NP_391402.1" /db_xref="EnsemblGenomes-Gn:BSU35220" /db_xref="EnsemblGenomes-Tr:CAB15539" /db_xref="GOA:O34375" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14111" /db_xref="UniProtKB/Swiss-Prot:O34375" /translation="MSVQWGIELLKSAGLFFLHPLFWFFIIITLAFGYVRIKRERKTF HTRIADIYDDLKFTYTKGLIPGLLLSVILGGLGISIPLGLLAIIAVITAAAAFTLRAN WMSAAYIVSVSMLIGFGLQIYQAEPFLERFPQGFAVVWPAVAVFLGLLIITEGAVAYR SAHVRTSPALVVSSRGLPIGQQLANRVWLLPLFLLVPGNGLESHLSWWPVFTVPGGSF HFLWIPYFVGFGQRVQGSLPETSIRITAKRVCILGLAVAVLGAASLLWTPLAGAAVCT ALLGRIFLSIKQRVNDNAAPFYFSKRDQGLMVLGIIPNTPAEDLELKIGEIITKVNGI PVKNVSDFYEALQHNRAYVKLEIIGLNGEIRFDQRASYEGEHHELGILFVKDDREDEA VASGS*" /label="minJ CDS" gene complement(3095018..3096211) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /label="minJ gene" downshifts complement(3095027) /Source="Nicolas_upshifts" /id="D1823" /incds=0 /nref=3 /ntot=85 /MaxReadThrough="3.18641" /MaxDrop="3.13207" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=66 /isTUend="FALSE" /label="downshifts" downshifts complement(3095092) /Source="Nicolas_upshifts" /id="D1824" /incds=1 /nref=94 /ntot=239 /MaxReadThrough="4.11808" /MaxDrop="4.31508" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(3096212..3096289) /Source="Nicolas_S_feature" /locus_tag="new_3621540_3621617_c" /HighExp="LBGstat, Lbstat, M0t90, Cold, M/G, GM 10, GM 25, GM 15, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1344" downshifts complement(3096215) /Source="Nicolas_upshifts" /id="D1825" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="6.36185" /MaxDrop="3.35962" /score="-9.46264764" /energy="-7.1" /TU="U2760,U2761,U2762" /idTUdmin="U2762" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(3096290..3096628) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16030230" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16030230; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein fragment; C-terminal part of swrAA" /db_xref="GOA:O32266" /db_xref="InterPro:IPR035388" /db_xref="PSEUDO:CAB15540.1" /db_xref="SubtiList:BG14160" /db_xref="UniProtKB/Swiss-Prot:O32266" /translation="MCVKKKYYELVEQLKDRTQDVTFSATKALSLLMLFSRYLVNYTN VESVNDINEECAKHYFNYLMKNHKRLGINLTDIKRSMHLISGLLDVDVNHYLKDFSLS NVTLWMTQER*" /label="swrAAc CDS" gene complement(3096290..3096628) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /pseudo /label="swrAAc gene" CDS complement(3096603..3096719) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein; N-terminal part of swrAA" /db_xref="PSEUDO:CAX52697.1" /translation="MLVSTPVLLLILARAYLYKENGGSQLKRASIVREKKIL*" /label="swrAAn CDS" gene complement(3096603..3096719) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /pseudo /label="swrAAn gene" S_feature complement(3096720..3096809) /Source="Nicolas_S_feature" /locus_tag="new_3622048_3622137_c" /HighExp="LBGstat, M0t90, Cold, Lbstat, GM 25, Gly, nit, GM 15, GM 10, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1345" promotor_-10 complement(3096791..3096809) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3096809) /Source="Nicolas_upshifts" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3096811..3096891) /Source="Nicolas_S_feature" /locus_tag="new_3622139_3622219_c" /HighExp="LBGstat, Lbstat, Cold, M0t90, GM 25, nit, Gly, M/G, MG 150, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigGF" /TUshortPSig="0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1346" promotor_-35 complement(3096823..3096828) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3096877..3096895) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3096891) /Source="Nicolas_upshifts" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3096909..3096916) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3097028..3098470) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14526016, 17557826, 27342562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526016, 17557826, 27342562; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="PDZ-containing carboxyl-terminal protease processing protease [Zn(II)]" /protein_id="NP_391404.1" /db_xref="EnsemblGenomes-Gn:BSU35240" /db_xref="EnsemblGenomes-Tr:CAB15541" /db_xref="GOA:O35002" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="PDB:4C2C" /db_xref="PDB:4C2D" /db_xref="PDB:4C2E" /db_xref="PDB:4C2F" /db_xref="PDB:4C2G" /db_xref="PDB:4C2H" /db_xref="SubtiList:BG14110" /db_xref="UniProtKB/Swiss-Prot:O35002" /translation="MNQKIMAVIAAGSMLFGGAGVYAGINLLEMDKPQTAAVPATAQA DSERDKAMDKIEKAYELISNEYVEKVDREKLLEGAIQGMLSTLNDPYSVYMDKQTAKQ FSDSLDSSFEGIGAEVGMEDGKIIIVSPFKKSPAEKAGLKPNDEIISINGESMAGKDL NHAVLKIRGKKGSSVSMKIQRPGTKKQLSFRIKRAEIPLETVFASEKKVQGHSVGYIA ISTFSEHTAEDFAKALRELEKKEIEGLVIDVRGNPGGYLQSVEEILKHFVTKDQPYIQ IAERNGDKKRYFSTLTHKKAYPVNVITDKGSASASEILAGALKEAGHYDVVGDTSFGK GTVQQAVPMGDGSNIKLTLYKWLTPNGNWIHKKGIEPTIAIKQPDYFSAGPLQLKEPL KVDMNNEDVKHAQVLLKGLSFDPGREDGYFSKDMKKAVMAFQDQNKLNKTGVIDTRTA ETLNQQIEKKKSDEKNDLQLQTALKSLFVN*" /label="ctpB CDS" gene complement(3097028..3098470) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /label="ctpB gene" downshifts complement(3097117) /Source="Nicolas_upshifts" /id="D1826" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="3.56833" /MaxDrop="3.1636" /score="0.562448109" /energy="-11.6" /TU="U2762" /idTUdmin="U2762" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3098516..3098527) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3098527) /Source="Nicolas_upshifts" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3098542..3098548) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3098610..3099500) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 23855774, 23869552" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 23855774, 23869552; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-division ABC transporter" /protein_id="NP_391405.1" /db_xref="EnsemblGenomes-Gn:BSU35250" /db_xref="EnsemblGenomes-Tr:CAB15542" /db_xref="GOA:O34876" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR004513" /db_xref="SubtiList:BG12591" /db_xref="UniProtKB/Swiss-Prot:O34876" /translation="MIKILGRHLRESFKSLGRNTWMTFASISAVTVTLILVGVFLVIM LNLNNMATNAEKQVEIKVLIDLTADQKAQDKLQNDIKELKGIQSVTFSSKEKELDQLV DSFGDSGKSLTMKDQENPLNDAFVVKTTDPHDTPNVAKKIEKMDHVYKVTYGKEEVSR LFKVVGVSRNIGIALIIGLVFTAMFLISNTIKITIFARRKEIEIMKLVGATNWFIRWP FFLEGLLLGVFGSVIPIALVLSTYQYVIGWVVPKVQGSFVSLLPYNPFVFQVSLVLIA IGAVIGVWGSLTSIRKFLRV*" /label="ftsX CDS" gene complement(3098610..3099500) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /label="ftsX gene" downshifts complement(3098627) /Source="Nicolas_upshifts" /id="D1827" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="3.3693" /MaxDrop="6.15417" /score="15.3496791" /energy="-14.6" /TU="U2763" /idTUdmin="U2763" /TUdmin="-102" /isTUend="FALSE" /label="downshifts" CDS complement(3099493..3100179) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division signal transducer (ATP-binding protein)" /protein_id="NP_391406.1" /db_xref="EnsemblGenomes-Gn:BSU35260" /db_xref="EnsemblGenomes-Tr:CAB15543" /db_xref="GOA:O34814" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005286" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12590" /db_xref="UniProtKB/Swiss-Prot:O34814" /translation="MIEMKEVYKAYPNGVKALNGISVTIHPGEFVYVVGPSGAGKSTF IKMIYREEKPTKGQILINHKDLATIKEKEIPFVRRKIGVVFQDFKLLPKLTVFENVAF ALEVIGEQPSVIKKRVLEVLDLVQLKHKARQFPDQLSGGEQQRVSIARSIVNNPDVVI ADEPTGNLDPDTSWEVMKTLEEINNRGTTVVMATHNKEIVNTMKKRVIAIEDGIIVRD ESRGEYGSYD*" /label="ftsE CDS" gene complement(3099493..3100179) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /label="ftsE gene" S_feature complement(3100180..3100312) /Source="Nicolas_S_feature" /locus_tag="new_3625508_3625640_c" /HighExp="Cold, UNK1, MG-0.2, MG 15, MG-0.1, C30, MG 25, MG 10, M9-exp, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.998" /label="S1347" promotor_-10 complement(3100302..3100321) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3100312) /Source="Nicolas_upshifts" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3100336..3100339) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3100413..3100751) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10473570, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10473570, 19222757; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome c551" /protein_id="NP_391407.1" /db_xref="EnsemblGenomes-Gn:BSU35270" /db_xref="EnsemblGenomes-Tr:CAB15544" /db_xref="GOA:O34594" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG12574" /db_xref="UniProtKB/Swiss-Prot:O34594" /translation="MKSKLSILMIGFALSVLLAACGSNDAKEEKTDTGSKTEATASEG EELYQQSCVGCHGKDLEGVSGPNLQEVGGKYDEHKIESIIKNGRGNMPKGLVDDNEAA VIAKWLSEKK*" /label="cccB CDS" gene complement(3100413..3100751) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /label="cccB gene" downshifts complement(3100414) /Source="Nicolas_upshifts" /id="D1828" /incds=0 /nref=192 /ntot=265 /MaxReadThrough="3.58546" /MaxDrop="6.88513" /score="18.0901387" /energy="-16.8" /TU="U2764" /idTUdmin="U2765" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3100778..3100797) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3100791) /Source="Nicolas_upshifts" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" CDS complement(3100800..3101684) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10473570, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391408.2" /db_xref="EnsemblGenomes-Gn:BSU35280" /db_xref="EnsemblGenomes-Tr:CAB15545" /db_xref="GOA:O34792" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG14109" /db_xref="UniProtKB/Swiss-Prot:O34792" /translation="MLSESIGRNGGYMMDVRNKTLWILRDYVYILIGAAITAVSFNVF LLPNKIAAGGVSGISTILQSYGFEAAYVQWIINIPLFIAGVILLGGKFGLKTLAGSVF LPLVVFLTRDIQPATHHELLAAIFGGVGIGIGIGIVYLGKGSTGGTALAAQIIHKYSG LSLGKCLAIIDGMIVVTAMIVFNIEQGLYAMLGVYVSSKTIDVVQVGFNRSKMALIIT KQEQAVKEAVLQKIDRGVTKISAVGGYTDDDRPILMCVVGQTEFTKLKQIVKQIDESA FVIVADASEVLGEGFKRA*" /label="yvjA CDS" gene complement(3100800..3101684) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /label="yvjA gene" promotor_-35 complement(3100811..3100818) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" promotor_-10 complement(3101672..3101691) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3101693) /Source="Nicolas_upshifts" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" promotor_-35 complement(3101706..3101713) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" CDS join(complement(3102841..3102912), complement(3101811..3102839)) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /experiment="publication(s) with functional evidences, PMID:1408743, 9696765, 9882663" /ribosomal_slippage /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1408743, 9696765, 9882663; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 2" /protein_id="NP_391409.1" /db_xref="EnsemblGenomes-Gn:BSU35290" /db_xref="EnsemblGenomes-Tr:CAB15546" /db_xref="GOA:P28367" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004374" /db_xref="InterPro:IPR005139" /db_xref="InterPro:IPR020853" /db_xref="SubtiList:BG10742" /db_xref="UniProtKB/Swiss-Prot:P28367" /translation="MELSEIRAELENMASRLADFRGSLDLESKEARIAELDEQMADPE FWNDQQKAQTVINEANGLKDYVNSYKKLNESHEELQMTHDLLKEEPDTDLQLELEKEL KSLTKEFNEFELQLLLSEPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWGERRGF KVETLDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVS CEVMPEFNDEIDIDIRTEDIKVDTYRASGAGGQHVNTTDSAVRITHLPTNVVVTCQTE RSQIKNRERAMKMLKAKLYQRRIEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSMVK DHRTNTEMGNVQAVMDGDIDTFIDAYLRSKLS*" /label="prfB CDS" gene complement(3101811..3102912) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /label="prfB gene" downshifts complement(3101827) /Source="Nicolas_upshifts" /id="D1829" /incds=0 /nref=193 /ntot=257 /MaxReadThrough="2.78016" /MaxDrop="6.41678" /score="27.1588259" /energy="-9.8" /TU="NA" /idTUdmin="U2766" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(3102913..3102981) /Source="Nicolas_S_feature" /locus_tag="new_3628241_3628309_c" /HighExp="Etha, Sw, Cold, BC, G150, BI, dia15, Mt0, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1348" CDS complement(3102982..3105507) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="translocase binding subunit (ATPase)" /protein_id="NP_391410.1" /db_xref="EnsemblGenomes-Gn:BSU35300" /db_xref="EnsemblGenomes-Tr:CAB15547" /db_xref="GOA:P28366" /db_xref="InterPro:IPR000185" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR011115" /db_xref="InterPro:IPR011116" /db_xref="InterPro:IPR011130" /db_xref="InterPro:IPR014018" /db_xref="InterPro:IPR020937" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036266" /db_xref="InterPro:IPR036670" /db_xref="PDB:1M6N" /db_xref="PDB:1M74" /db_xref="PDB:1TF2" /db_xref="PDB:1TF5" /db_xref="PDB:2IBM" /db_xref="PDB:3DL8" /db_xref="PDB:3IQM" /db_xref="PDB:3IQY" /db_xref="PDB:3JV2" /db_xref="PDB:5EUL" /db_xref="SubtiList:BG10741" /db_xref="UniProtKB/Swiss-Prot:P28366" /translation="MLGILNKMFDPTKRTLNRYEKIANDIDAIRGDYENLSDDALKHK TIEFKERLEKGATTDDLLVEAFAVVREASRRVTGMFPFKVQLMGGVALHDGNIAEMKT GEGKTLTSTLPVYLNALTGKGVHVVTVNEYLASRDAEQMGKIFEFLGLTVGLNLNSMS KDEKREAYAADITYSTNNELGFDYLRDNMVLYKEQMVQRPLHFAVIDEVDSILIDEAR TPLIISGQAAKSTKLYVQANAFVRTLKAEKDYTYDIKTKAVQLTEEGMTKAEKAFGID NLFDVKHVALNHHINQALKAHVAMQKDVDYVVEDGQVVIVDSFTGRLMKGRRYSEGLH QAIEAKEGLEIQNESMTLATITFQNYFRMYEKLAGMTGTAKTEEEEFRNIYNMQVVTI PTNRPVVRDDRPDLIYRTMEGKFKAVAEDVAQRYMTGQPVLVGTVAVETSELISKLLK NKGIPHQVLNAKNHEREAQIIEEAGQKGAVTIATNMAGRGTDIKLGEGVKELGGLAVV GTERHESRRIDNQLRGRSGRQGDPGITQFYLSMEDELMRRFGAERTMAMLDRFGMDDS TPIQSKMVSRAVESSQKRVEGNNFDSRKQLLQYDDVLRQQREVIYKQRFEVIDSENLR EIVENMIKSSLERAIAAYTPREELPEEWKLDGLVDLINTTYLDEGALEKSDIFGKEPD EMLELIMDRIITKYNEKEEQFGKEQMREFEKVIVLRAVDSKWMDHIDAMDQLRQGIHL RAYAQTNPLREYQMEGFAMFEHMIESIEDEVAKFVMKAEIENNLEREEVVQGQTTAHQ PQEGDDNKKAKKAPVRKVVDIGRNAPCHCGSGKKYKNCCGRTE*" /label="secA CDS" gene complement(3102982..3105507) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /label="secA gene" S_feature complement(3105508..3105588) /Source="Nicolas_S_feature" /locus_tag="new_3630836_3630916_c" /HighExp="Etha, M9-stat, T0.30H, B60, dia5, Cold, dia15, Lbexp, Salt, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1349" misc_feature complement(3105578..3105597) /Source="Nicolas_upshift_promotors" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3105588) /Source="Nicolas_upshifts" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3105675..3106244) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome-associated sigma 54 modulation protein;ribosome dimerisation factor" /protein_id="NP_391411.1" /db_xref="EnsemblGenomes-Gn:BSU35310" /db_xref="EnsemblGenomes-Tr:CAB15548" /db_xref="GOA:P28368" /db_xref="InterPro:IPR003489" /db_xref="InterPro:IPR032528" /db_xref="InterPro:IPR034694" /db_xref="InterPro:IPR036567" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10740" /db_xref="UniProtKB/Swiss-Prot:P28368" /translation="MNYNIRGENIEVTPALKDHVERKIGKLERYFDHSVDADVNVNLK FYNDKESKVEVTIPMTDLALRSEVHNEDMYNAIDLATNKLERQIRKHKTKVNRKFREQ GSPKYLLANGLGSDTDIAVQDDIEEEESLDIVRQKRFNLKPMDSEEAILQMNMLGHNF FVFTNAETNLTNVVYRRNDGKYGLIEPTE*" /label="hpf CDS" gene complement(3105675..3106244) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /label="hpf gene" downshifts complement(3105683) /Source="Nicolas_upshifts" /id="D1830" /incds=0 /nref=78 /ntot=209 /MaxReadThrough="8.66806" /MaxDrop="4.7023" /score="29.9030506" /energy="-12.2" /TU="U2768,U2769,U2770,U2773" /idTUdmin="U2773" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 3106211..3106217 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3106230..3106249 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3106237 /Source="Nicolas_upshifts" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3106271..3106289) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3106279) /Source="Nicolas_upshifts" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3106281..3106401) /Source="Nicolas_S_feature" /locus_tag="new_3631609_3631729_c" /HighExp="C30, M0t90, S4, Lbstat, S5, M40t90, Glucon, Gly, C90, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigD, SigD" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1350" promotor_-35 complement(3106301..3106309) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3106385..3106403) /Source="Nicolas_upshift_promotors" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3106401) /Source="Nicolas_upshifts" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3106419..3106424) /Source="Nicolas_upshift_promotors" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3106435..3106812) /gene="yvzG" /locus_tag="BSU_35319" /old_locus_tag="BSU35319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097791.1" /db_xref="EnsemblGenomes-Gn:BSU35319" /db_xref="EnsemblGenomes-Tr:CAX52698" /db_xref="UniProtKB/Swiss-Prot:C0H3R9" /translation="MKSIEDYTLLSAYYHLLFTIEEGLCYLIEAEENLSKTEGDRIYQ DLIQAFFYLDSTHSTLLFIMDSRCAEICVKAFDQIFAEFDQLVSFSFPSHEFCEYLKE HFLIHYRKWMLSIHQCMEPFLIN*" /label="yvzG CDS" gene complement(3106435..3106812) /gene="yvzG" /locus_tag="BSU_35319" /old_locus_tag="BSU35319" /label="yvzG gene" CDS complement(3106822..3107163) /gene="fliT" /locus_tag="BSU_35320" /old_locus_tag="BSU35320" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16952964; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar assembly protein FliT involved in control of flagella expression" /protein_id="NP_391412.1" /db_xref="EnsemblGenomes-Gn:BSU35320" /db_xref="EnsemblGenomes-Tr:CAB15549" /db_xref="GOA:P39740" /db_xref="SubtiList:BG10923" /db_xref="UniProtKB/Swiss-Prot:P39740" /translation="MNNIDQLYTETKSMLSHIQNTPESDELLKQIEDFVATRSELIQE ISLPLSEEERKQMKLILTWDQLIVKEMERLKQSIATELQQMKRKRVMHTTYLNPYNNI TIDGTYYDKRK*" /label="fliT CDS" gene complement(3106822..3107163) /gene="fliT" /locus_tag="BSU_35320" /old_locus_tag="BSU35320" /label="fliT gene" CDS complement(3107160..3107561) /gene="fliS" /locus_tag="BSU_35330" /old_locus_tag="BSU35330" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16806204, 16936039, 20534509, 23144244, 23874669; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar assembly protein FliS" /protein_id="NP_391413.1" /db_xref="EnsemblGenomes-Gn:BSU35330" /db_xref="EnsemblGenomes-Tr:CAB15550" /db_xref="GOA:P39739" /db_xref="InterPro:IPR003713" /db_xref="InterPro:IPR036584" /db_xref="PDB:1VH6" /db_xref="SubtiList:BG10922" /db_xref="UniProtKB/Swiss-Prot:P39739" /translation="MAIQNPYTAYQQNSVNTATPGELTLMLYNGCLKFIRLAAQAIEN DDMERKNENLIKAQNIIQELNFTLNRNIELSASMGAMYDYMYRRLVQANIKNDTGMLA EVEGYVTDFRDAWKQAIQSERKDRHGSGGIA*" /label="fliS CDS" gene complement(3107160..3107561) /gene="fliS" /locus_tag="BSU_35330" /old_locus_tag="BSU35330" /label="fliS gene" CDS complement(3107583..3109079) /gene="fliD" /locus_tag="BSU_35340" /old_locus_tag="BSU35340" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9648743, 12354229, 24296669, 25355936; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-associated capping protein 2 (HAP2)" /protein_id="NP_391414.1" /db_xref="EnsemblGenomes-Gn:BSU35340" /db_xref="EnsemblGenomes-Tr:CAB15551" /db_xref="GOA:P39738" /db_xref="InterPro:IPR003481" /db_xref="InterPro:IPR010809" /db_xref="InterPro:IPR010810" /db_xref="SubtiList:BG10921" /db_xref="UniProtKB/Swiss-Prot:P39738" /translation="MVTRITGLASGMDIDDIVSKLMQTERAPLDKLTQKKQTLEWQRD SYREVNSKIKELQDYMSKNTLTYPSTYQSKTVTSSNESVLTATGSVSAPNSSSTVEVA SLATAATYKANNYTGYTQGDYNLAFNVVAPGETTAKTVNISVTSADTIDNVISKLNSS DLGVSAFKDKIWNGTEYVETIAFSSKATGAGGSIQAADSATADFMSGQLGFSLDADNK LTAYKEGTNAKVTINGFEMEKLTNNFTVNGVTYSIKNTTAATGPVTTSVSTDVDGIYN QIKEFVDKYNELVDSLNEKLKEEKYRDYTPLTSEQKEAMSDKEVELWEEKAKSGLLRN DSSISTGTNQMRTDFYTQVNADGKTYQLTEFGITTSSAYQLRGHLEINEEKLKAKIAE DPQGVANLFTSGTNDSNYSDKGIMKRITNTLRSTVKSIEAKAGNSTMGASSYSIGKNL NSISTEITDMQDRLNTIENRYYSKFSAMDSAIQKMNEQASYLSQLLVQ*" /label="fliD CDS" gene complement(3107583..3109079) /gene="fliD" /locus_tag="BSU_35340" /old_locus_tag="BSU35340" /label="fliD gene" CDS complement(3109097..3109426) /gene="yvyC" /locus_tag="BSU_35350" /old_locus_tag="BSU35350" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 19455708; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative flagellar protein of unknown function" /protein_id="NP_391415.1" /db_xref="EnsemblGenomes-Gn:BSU35350" /db_xref="EnsemblGenomes-Tr:CAB15552" /db_xref="InterPro:IPR005186" /db_xref="InterPro:IPR035924" /db_xref="PDB:2HC5" /db_xref="SubtiList:BG10920" /db_xref="UniProtKB/Swiss-Prot:P39737" /translation="MNIERLTTLQPVWDRYDTQIHNQKDNDNEVPVHQVSYTNLAEMV GEMNKLLEPSQVHLKFELHDKLNEYYVKVIEDSTNEVIREIPPKRWLDFYAAMTEFLG LFVDEKK*" /label="yvyC CDS" gene complement(3109097..3109426) /gene="yvyC" /locus_tag="BSU_35350" /old_locus_tag="BSU35350" /label="yvyC gene" downshifts 3109423 /Source="Nicolas_upshifts" /id="D1831" /incds=0 /nref=33 /ntot=140 /MaxReadThrough="2.74277" /MaxDrop="4.24086" /score="8.30527041" /energy="-10.1" /TU="NA" /idTUdmin="U2774" /TUdmin="-3062" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3109448..3109466) /Source="Nicolas_upshift_promotors" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3109463) /Source="Nicolas_upshifts" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3109465..3109569) /Source="Nicolas_S_feature" /locus_tag="new_3634793_3634897_c" /HighExp="Lbstat, Cold, Gly, S0, Glu, Pyr, M/G, M0t90, C30, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1351" promotor_-35 complement(3109480..3109487) /Source="Nicolas_upshift_promotors" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3109558..3109577) /Source="Nicolas_upshift_promotors" /id="U2771" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2693 /SigmaFactorBS="tcttttaatttaaatttctatctcctaatcattcctcatcct gtcactaactCATGATATAATAACCGGATTctccactaactttttataaatgtatttc c" /listShort="S1351, yvyC, fliD, fliS, fliT, yvzG" /listLong="S1350, yvyD, S1349, secA, S1348, prfB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3109569) /Source="Nicolas_upshifts" /id="U2771" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2693 /SigmaFactorBS="tcttttaatttaaatttctatctcctaatcattcctcatcct gtcactaactCATGATATAATAACCGGATTctccactaactttttataaatgtatttc c" /listShort="S1351, yvyC, fliD, fliS, fliT, yvzG" /listLong="S1350, yvyD, S1349, secA, S1348, prfB" /label="upshifts" CDS complement(3109659..3110573) /gene="hag" /locus_tag="BSU_35360" /old_locus_tag="BSU35360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8045886, 9648743, 12730172, 14762011, 15342569, 22720735, 25355936, 28800172, 29124898" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045886, 9648743, 12730172, 14762011, 15342569, 22720735, 25355936, 28800172, 29124898; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellin protein" /protein_id="NP_391416.1" /db_xref="EnsemblGenomes-Gn:BSU35360" /db_xref="EnsemblGenomes-Tr:CAB15553" /db_xref="GOA:P02968" /db_xref="InterPro:IPR001029" /db_xref="InterPro:IPR001492" /db_xref="SubtiList:BG10655" /db_xref="UniProtKB/Swiss-Prot:P02968" /translation="MRINHNIAALNTLNRLSSNNSASQKNMEKLSSGLRINRAGDDAA GLAISEKMRGQIRGLEMASKNSQDGISLIQTAEGALTETHAILQRVRELVVQAGNTGT QDKATDLQSIQDEISALTDEIDGISNRTEFNGKKLLDGTYKVDTATPANQKNLVFQIG ANATQQISVNIEDMGADALGIKEADGSIAALHSVNDLDVTKFADNAADTADIGFDAQL KVVDEAINQVSSQRAKLGAVQNRLEHTINNLSASGENLTAAESRIRDVDMAKEMSEFT KNNILSQASQAMLAQANQQPQNVLQLLR*" /label="hag CDS" gene complement(3109659..3110573) /gene="hag" /locus_tag="BSU_35360" /old_locus_tag="BSU35360" /label="hag gene" downshifts complement(3109679) /Source="Nicolas_upshifts" /id="D1832" /incds=0 /nref=165 /ntot=233 /MaxReadThrough="5.58531" /MaxDrop="7.10921" /score="11.6997504" /energy="-13.1" /TU="U2773" /idTUdmin="U2775" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" S_feature complement(3110574..3110682) /Source="Nicolas_S_feature" /locus_tag="new_3635902_3636010_c" /HighExp="T2.0H, Glucon, M0t90, T2.30H, GM 15, T-0.40H, GM 10, T1.0H, T-1.10H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1352" promotor_-35 3110640..3110641 /Source="Nicolas_upshift_promotors" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3110650..3110664 /Source="Nicolas_upshift_promotors" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3110659 /Source="Nicolas_upshifts" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3110661..3110679) /Source="Nicolas_upshift_promotors" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="promotor_-10" upshifts complement(3110682) /Source="Nicolas_upshifts" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="upshifts" promotor_-35 complement(3110692..3110699) /Source="Nicolas_upshift_promotors" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="promotor_-35" CDS complement(3110718..3110942) /gene="csrA" /locus_tag="BSU_35370" /old_locus_tag="BSU35370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8982093, 17555441, 21895793, 23144244, 27516547" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8982093, 17555441, 21895793, 23144244, 27516547; Product type r: regulator" /codon_start=1 /transl_table=11 /product="carbon storage regulator" /protein_id="NP_391417.1" /db_xref="EnsemblGenomes-Gn:BSU35370" /db_xref="EnsemblGenomes-Tr:CAB15554" /db_xref="GOA:P33911" /db_xref="InterPro:IPR003751" /db_xref="InterPro:IPR036107" /db_xref="PDB:1T3O" /db_xref="SubtiList:BG10654" /db_xref="UniProtKB/Swiss-Prot:P33911" /translation="MLVLSRKINEAIQIGADIEVKVIAVEGDQVKLGIDAPKHIDIHR KEIYLTIQEENNRAAALSSDVISALSSQKK*" /label="csrA CDS" gene complement(3110718..3110942) /gene="csrA" /locus_tag="BSU_35370" /old_locus_tag="BSU35370" /label="csrA gene" downshifts complement(3110757) /Source="Nicolas_upshifts" /id="D1833" /incds=0 /nref=22 /ntot=171 /MaxReadThrough="2.28652" /MaxDrop="3.46262" /score="31.5820557" /energy="-9.2" /TU="NA" /idTUdmin="U2775" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3110936..3111367) /gene="fliW" /locus_tag="BSU_35380" /old_locus_tag="BSU35380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15033535, 16936039, 21895793, 27516547" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15033535, 16936039, 21895793, 27516547; Product type f: factor" /codon_start=1 /transl_table=11 /product="assembly factor of the flagellum" /protein_id="NP_391418.1" /db_xref="EnsemblGenomes-Gn:BSU35380" /db_xref="EnsemblGenomes-Tr:CAB15555" /db_xref="GOA:P96503" /db_xref="InterPro:IPR003775" /db_xref="InterPro:IPR024046" /db_xref="SubtiList:BG12451" /db_xref="UniProtKB/Swiss-Prot:P96503" /translation="MIIHTKYHGQMNIKEEQIILFESGIPGFLEEKQFVILPLSEDSP FVALQSVTSENLAFIVVSPFIFFKNYEFDLDESTAELLDIDNIQDVEVMTILTMAEPF EKSTANLLAPIIVNRKNMMAKQVVLHDSSYTTKHPIGGESC*" /label="fliW CDS" gene complement(3110936..3111367) /gene="fliW" /locus_tag="BSU_35380" /old_locus_tag="BSU35380" /label="fliW gene" CDS complement(3111388..3111963) /gene="yviE" /locus_tag="BSU_35390" /old_locus_tag="BSU35390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391419.1" /db_xref="EnsemblGenomes-Gn:BSU35390" /db_xref="EnsemblGenomes-Tr:CAB15556" /db_xref="SubtiList:BG12450" /db_xref="UniProtKB/Swiss-Prot:P96502" /translation="MQIPRLIMHSVQGKIGLTTTPASLKMEQPQADLEIEQPSAEMEI SVTPGKLTIDQTQAWEELDRKHVFKRIEEAAQQGHEDVMEGIARTAEEGDELMKIENK GNPIASQARRNSEMHQIQLGENYAPSLSRVKIQYTPSQLDVQITPRKPVIQAEPHKPI VEYTPGNVKVDMLQYPDLNIDVEYPKESPEK*" /label="yviE CDS" gene complement(3111388..3111963) /gene="yviE" /locus_tag="BSU_35390" /old_locus_tag="BSU35390" /label="yviE gene" CDS complement(3112010..3112906) /gene="flgL" /locus_tag="BSU_35400" /old_locus_tag="BSU35400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2407720, 15033535, 17438286, 23874669, 24296669, 24706744; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar hook-filament junction protein" /protein_id="NP_391420.1" /db_xref="EnsemblGenomes-Gn:BSU35400" /db_xref="EnsemblGenomes-Tr:CAB15557" /db_xref="GOA:P96501" /db_xref="InterPro:IPR001029" /db_xref="InterPro:IPR013384" /db_xref="SubtiList:BG11936" /db_xref="UniProtKB/Swiss-Prot:P96501" /translation="MRVTQGMIQQNSLRYIGSSYSKLDKLQSQISSGKKISKASDDPV VAMKSLKYNTQLSQVQQYKSNASQAFTWLENTETNITEGIDILSKVRELAVEAQNDTN GEPERQAIGVEVKQLKEQLLNIANTQVNGRYIFNGTNSDKPPVTDNGDGTYTISDTAD VVVNISNNMSLKVNSDPKSAFGGTSESGQNVFEMLDSFEKALNSGSLDGMDSVLNDID HFSDGMSAERSDLGARYNRLELVNTRLSAQEETATKVLSDNEDVELEEVITEFIAQQS VHRATLAVNAQIVQPTLIDFLK*" /label="flgL CDS" gene complement(3112010..3112906) /gene="flgL" /locus_tag="BSU_35400" /old_locus_tag="BSU35400" /label="flgL gene" downshifts complement(3112033) /Source="Nicolas_upshifts" /id="D1834" /incds=0 /nref=112 /ntot=251 /MaxReadThrough="5.50861" /MaxDrop="3.8234" /score="0.376587888" /energy="-4.8" /TU="U2775,U2776,U2777" /idTUdmin="U2777" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" misc_feature 3112322..3112325 /Source="Nicolas_upshift_promotors" /id="U2774" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.97902097902098" /psig="0.000999000999001" /xcortree=54 /SigmaFactorBS="actgtccatgccatctagcgaaccagaatttagtgctttctc aaaagaatcAAGCatttcaaatacattctgcccgctttcagaagtgcctccaaaagct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3112331 /Source="Nicolas_upshifts" /id="U2774" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.97902097902098" /psig="0.000999000999001" /xcortree=54 /SigmaFactorBS="actgtccatgccatctagcgaaccagaatttagtgctttctc aaaagaatcAAGCatttcaaatacattctgcccgctttcagaagtgcctccaaaagct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3112917..3114440) /gene="flgK" /locus_tag="BSU_35410" /old_locus_tag="BSU35410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2407720, 15033535, 17438286, 23874669, 24296669, 24706744; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar hook-filament junction" /protein_id="NP_391421.1" /db_xref="EnsemblGenomes-Gn:BSU35410" /db_xref="EnsemblGenomes-Tr:CAB15558" /db_xref="GOA:P39810" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR002371" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10401" /db_xref="UniProtKB/Swiss-Prot:P39810" /translation="MTSTFMGLETARRALSAQQAALSTTANNVANANTDGYTRQRVSL EATDYFPAVSKNAEKTAGQMGTGVQGKSVERIRDIFLDYQYRLQNNSAGYYDTKAKAL SQMEGVLNETDDSGLNSVLNSFWNSLQELSNNTNEESARSVVARKGQAVAETFNYISE SLTNVQSNLKAELNTTVLDVNSLLSQLNSLNKQIAQVEPVGLLPNGLYDQRDLLIDKL SSMVDIKVSYNKSGGNALASAEGTVSIEILDKNKQSLGTVLDGKNYEVSELAANYDNE TGLVSSISIGDTAVQAESFSSKGSLLGFIESYGYITADGQEKGVYPEMLSDLDNMALE FAKAFNEVHRNGVTKSGEQGGDFFDFTGGETEPAKGAAGKIKVADSIIDSKGANIAFS LTGAANDNANATKLANVLTGKITINGKETSVLDYYAGLIGELGIEAQEANRLASNTET QLNDADINRQQMSAVSLDEEMTNMIQFQHAYNAAARMVTLQDELLDKVINGMGVGGR* " /label="flgK CDS" gene complement(3112917..3114440) /gene="flgK" /locus_tag="BSU_35410" /old_locus_tag="BSU35410" /label="flgK gene" CDS complement(3114459..3114941) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:24706744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24706744; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for flagellar based motility" /protein_id="NP_391422.1" /db_xref="EnsemblGenomes-Gn:BSU35420" /db_xref="EnsemblGenomes-Tr:CAB15559" /db_xref="GOA:P39808" /db_xref="InterPro:IPR007809" /db_xref="InterPro:IPR036679" /db_xref="SubtiList:BG10400" /db_xref="UniProtKB/Swiss-Prot:P39808" /translation="MSAKAIIEQLKRLCVLHEHLLTLSEEKTEALKAGKTKELSNILT KEQKYIQAITQTEDDRIKTTSAFLGYSENNTISACIAKTSGSEKEELEQLYESLSQVL GRLKKVNEMNRQLTRDALQFISISYDMLVPKENNFNYSKSIKAELPKSSKMKLFDSKA *" /label="flgN CDS" gene complement(3114459..3114941) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /label="flgN gene" CDS complement(3114957..3115223) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma factor repressor of sigma(D)-dependent transcription" /protein_id="NP_391423.1" /db_xref="EnsemblGenomes-Gn:BSU35430" /db_xref="EnsemblGenomes-Tr:CAB15560" /db_xref="GOA:P39809" /db_xref="InterPro:IPR007412" /db_xref="InterPro:IPR031316" /db_xref="InterPro:IPR035890" /db_xref="SubtiList:BG10399" /db_xref="UniProtKB/Swiss-Prot:P39809" /translation="MKINQFGTQSVNPYQKNYDKQAVQKTVAQPQDKIEISSQAKEMQ HASDAVTGSRQEKIAQLKAQIENGSYKVDANHIAKNMINFYKKQ*" /label="flgM CDS" gene complement(3114957..3115223) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /label="flgM gene" S_feature complement(3115224..3115303) /Source="Nicolas_S_feature" /locus_tag="new_3640552_3640631_c" /HighExp="T0.30H, Cold, C90, T-5.40H, T-4.40H, GM 150, T-2.40H, GM 45, S2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1353" CDS complement(3115304..3115723) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696775; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of flagella formation" /protein_id="NP_391424.1" /db_xref="EnsemblGenomes-Gn:BSU35440" /db_xref="EnsemblGenomes-Tr:CAB15561" /db_xref="GOA:P39807" /db_xref="InterPro:IPR022258" /db_xref="SubtiList:BG10398" /db_xref="UniProtKB/Swiss-Prot:P39807" /translation="MGELANCPKCNALFLKTKLQTVCQACIKEEEKSFETVYKFLRKQ ENRQSTLSRITEETGVEEELILKFIRQKRIQITHLPNLAYPCERCGTSIREGKFCKAC QSDIKDQMDHLNHEDALKIEKENSKKDTYYAYNTKNS*" /label="yvyF CDS" gene complement(3115304..3115723) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /label="yvyF gene" promotor_-10 complement(3115762..3115780) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3115773) /Source="Nicolas_upshifts" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3115794..3115801) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3115797..3116519) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 28618091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the DNA transport apparatus" /protein_id="NP_391425.2" /db_xref="EnsemblGenomes-Gn:BSU35450" /db_xref="EnsemblGenomes-Tr:CAB15562" /db_xref="GOA:P39147" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005222" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10397" /db_xref="UniProtKB/Swiss-Prot:P39147" /translation="MSNEAGGGIHKLICLLCDSQFSQDVTWRALFLLKPDEKVCYSCR SKLKKITGHICPLCGRPQSVHAVCRDCEVWRTRIRDSLLLRQNRSVYTYNDMMKETLS RFKFRGDAEIINAFKSDFSSTFSKVYPDKHFVLVPIPLSKEREEERGFNQAHLLAECL DRPSHHPLIRLNNEKQSKKKKTERLLSECIFDTKNNSAEGMNIILIDDLYTTGATLHF AARCLLEKGKAASVSSFTLIRS*" /label="comFC CDS" gene complement(3115797..3116519) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /label="comFC gene" CDS complement(3116483..3116779) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 25423369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 25423369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of competence, pole located" /protein_id="NP_391426.1" /db_xref="EnsemblGenomes-Gn:BSU35460" /db_xref="EnsemblGenomes-Tr:CAB15563" /db_xref="GOA:P39146" /db_xref="InterPro:IPR019657" /db_xref="PDB:4WAI" /db_xref="SubtiList:BG10396" /db_xref="UniProtKB/Swiss-Prot:P39146" /translation="MLVNSKEIVMKELLDRYMDQLHMACTCQVCQNDVLALSLNKVSP SYVTDFKKIAYTKAELVDKQKNTAMLVILAESAAVVSESPSDLCQTKQEEAFIN*" /label="comFB CDS" gene complement(3116483..3116779) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /label="comFB gene" promotor_-10 complement(3116805..3116824) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3116818) /Source="Nicolas_upshifts" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3116835..3116842) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3116839..3118230) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045895, 11359569, 12123453, 16009133, 21397556, 28559293" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045895, 11359569, 12123453, 16009133, 21397556, 28559293; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase competence protein" /protein_id="NP_391427.1" /db_xref="EnsemblGenomes-Gn:BSU35470" /db_xref="EnsemblGenomes-Tr:CAB15564" /db_xref="GOA:P39145" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10395" /db_xref="UniProtKB/Swiss-Prot:P39145" /translation="MNVPVEKNSSFSKELQQTLRSRHLLRTELSFSDEMIEWHIKNGY ITAENSISINKRRYRCNRCGQTDQRYFSFYHSSGKNKLYCRSCVMMGRVSEEVPLYSW KEENESNWKSIKLTWDGKLSSGQQKAANVLIEAISKKEELLIWAVCGAGKTEMLFPGI ESALNQGLRVCIATPRTDVVLELAPRLKAAFQGADISALYGGSDDKGRLSPLMISTTH QLLRYKDAIDVMIIDEVDAFPYSADQTLQFAVQKARKKNSTLVYLSATPPKELKRKAL NGQLHSVRIPARHHRKPLPEPRFVWCGNWKKKLNRNKIPPAVKRWIEFHVKEGRPVFL FVPSVSILEKAAACFKGVHCRTASVHAEDKHRKEKVQQFRDGQLDLLITTTILERGVT VPKVQTGVLGAESSIFTESALVQIAGRTGRHKEYADGDVIYFHFGKTKSMLDARKHIK EMNELAAKVECTD*" /label="comFA CDS" gene complement(3116839..3118230) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /label="comFA gene" promotor_-10 complement(3118244..3118263) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3118259) /Source="Nicolas_upshifts" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3118277..3118284) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3118336..3119181) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /EC_number="2.7.2.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit A" /protein_id="NP_391428.1" /db_xref="EnsemblGenomes-Gn:BSU35480" /db_xref="EnsemblGenomes-Tr:CAB15565" /db_xref="GOA:P32436" /db_xref="InterPro:IPR003797" /db_xref="PDB:3FYS" /db_xref="SubtiList:BG10394" /db_xref="UniProtKB/Swiss-Prot:P32436" /translation="MNIAVVTDSTAYIPKEMREQHQIHMIPLQVVFREETYREEIELD WKSFYEEVKKHNELPTTSQPPIGELVALYEELGKSYDAVISIHLSSGISGTFSSAAAA DSMVDNIDVYPFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELEEMKKTVRAYFM VDDLAHLQRGGRLSSAQAFIGSLLKVKPILHFDNKVIVPFEKIRTRKKAISRIYELLD EDASKGLPMRAAVIHANREEEAAKIIEELSAKYPHVEFYNSYFGAVIGTHLGEGALGI CWCFK*" /label="fakBA CDS" gene complement(3118336..3119181) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /label="fakBA gene" downshifts complement(3118347) /Source="Nicolas_upshifts" /id="D1835" /incds=0 /nref=207 /ntot=249 /MaxReadThrough="2.43976" /MaxDrop="5.65998" /score="25.7738948" /energy="-9.9" /TU="NA" /idTUdmin="U2779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3118598..3118605 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3118619..3118638 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3118629..3120361 /Source="Nicolas_S_feature" /locus_tag="new_3643957_3645689" /HighExp="C30, S2, C90, Pyr, T0.30H, GM 150, G/S, T-4.40H, T-3.40H, T1.30H" /AntisenseName="degU" /AntisenseCor="1.0564647169900101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1354" upshifts 3118629 /Source="Nicolas_upshifts" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3119208..3119227) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3119227) /Source="Nicolas_upshifts" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3119242..3119245) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3119279..3119968) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_391429.1" /db_xref="EnsemblGenomes-Gn:BSU35490" /db_xref="EnsemblGenomes-Tr:CAB15566" /db_xref="GOA:P13800" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10393" /db_xref="UniProtKB/Swiss-Prot:P13800" /translation="MTKVNIVIIDDHQLFREGVKRILDFEPTFEVVAEGDDGDEAARI VEHYHPDVVIMDINMPNVNGVEATKQLVELYPESKVIILSIHDDENYVTHALKTGARG YLLKEMDADTLIEAVKVVAEGGSYLHPKVTHNLVNEFRRLATSGVSAHPQHEVYPEIR RPLHILTRRECEVLQMLADGKSNRGIGESLFISEKTVKNHVSNILQKMNVNDRTQAVV VAIKNGWVEMR*" /label="degU CDS" gene complement(3119279..3119968) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /label="degU gene" downshifts complement(3119293) /Source="Nicolas_upshifts" /id="D1836" /incds=0 /nref=178 /ntot=235 /MaxReadThrough="5.12878" /MaxDrop="6.38336" /score="20.9249268" /energy="-12.8" /TU="U2781" /idTUdmin="U2779" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature complement(3119969..3120050) /Source="Nicolas_S_feature" /locus_tag="new_3645297_3645378_c" /HighExp="M40t90, Lbtran, M0t90, LBGtran, G180, T3.0H, M40t45, C90, T3.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1355" CDS complement(3120051..3121208) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [DegU]" /protein_id="NP_391430.1" /db_xref="EnsemblGenomes-Gn:BSU35500" /db_xref="EnsemblGenomes-Tr:CAB15567" /db_xref="GOA:P13799" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008595" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR016381" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10392" /db_xref="UniProtKB/Swiss-Prot:P13799" /translation="MNKTKMDSKVLDSILMKMLKTVDGSKDEVFQIGEQSRQQYEQLV EELKQIKQQVYEVIELGDKLEVQTRHARNRLSEVSRNFHRFSEEEIRNAYEKAHKLQV ELTMIQQREKQLRERRDDLERRLLGLQEIIERSESLVSQITVVLNYLNQDLREVGLLL ADAQAKQDFGLRIIEAQEEERKRVSREIHDGPAQMLANVMMRSELIERIFRDRGAEDG FQEIKNLRQNVRNALYEVRRIIYDLRPMALDDLGLIPTLRKYLYTTEEYNGKVKIHFQ CIGETEDQRLAPQFEVALFRLAQEAVSNALKHSESEEITVKVEITKDFVILMIKDNGK GFDLKEAKEKKNKSFGLLGMKERVDLLEGTMTIDSKIGLGTFIMIKVPLSL*" /label="degS CDS" gene complement(3120051..3121208) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /label="degS gene" S_feature complement(3121209..3121336) /Source="Nicolas_S_feature" /locus_tag="new_3646537_3646664_c" /HighExp="T0.30H, Lbtran, M9-stat, T3.0H, T1.0H, HiOs, T1.30H, T2.30H, T3.30H, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1356" promotor_-35 3121256..3121259 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3121274..3121293 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3121285..3121371 /Source="Nicolas_S_feature" /locus_tag="new_3646613_3646699" /HighExp="UNK1, Cold, C30, Lbexp, MG 15, G135, G180, G150, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1357" upshifts 3121285 /Source="Nicolas_upshifts" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3121330..3121349) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3121336) /Source="Nicolas_upshifts" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3121353..3121361 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3121360..3121367) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3121373 /Source="Nicolas_upshifts" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3121375..3121383 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3121425..3122078 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11116084, 15103642, 21239490, 22404850; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative translation regulator" /protein_id="NP_391431.1" /db_xref="EnsemblGenomes-Gn:BSU35510" /db_xref="EnsemblGenomes-Tr:CAB15568" /db_xref="InterPro:IPR001498" /db_xref="InterPro:IPR015269" /db_xref="InterPro:IPR015796" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020569" /db_xref="InterPro:IPR023582" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR036956" /db_xref="SubtiList:BG11052" /db_xref="UniProtKB/Swiss-Prot:P32437" /translation="MLHSYFTVKEAGEHEIVIEKSRFICHLSRVSTEQEAQEFIQKIK KQHWNATHNCSAYVIGENDHIQKANDDGEPSGTAGVPMLEVLKKRRLKDTCAVVTRYF GGIKLGAGGLIRAYGKSVSEGLNHIGVVERKLMRIMHTSADYTWLGKIENELRESQFL LKEIHYSENVEFETYVEEKETNAFSEWMTELTNGKSDIKEGELTYLEKAVNHIKETE* " /label="yvyE CDS" gene 3121425..3122078 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /label="yvyE gene" S_feature complement(3121781..3122373) /Source="Nicolas_S_feature" /locus_tag="new_3647109_3647701_c" /HighExp="Etha, M9-stat, Gly, C30, B60, Salt, T0.30H, Sw, LoTm, S8" /AntisenseName="yvyE" /AntisenseCor="-0.139956338862644" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1358" CDS 3122078..3123253 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19099556, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain" /protein_id="NP_391432.1" /db_xref="EnsemblGenomes-Gn:BSU35520" /db_xref="EnsemblGenomes-Tr:CAB15569" /db_xref="GOA:P96499" /db_xref="InterPro:IPR004474" /db_xref="PDB:3NXH" /db_xref="SubtiList:BG12449" /db_xref="UniProtKB/Swiss-Prot:P96499" /translation="MAERVRVRVRKKKKSKRRKILKRIMLLFALALLVVVGLGGYKLY KTINAADESYDALSRGNKSNLRNEVVDMKKKPFSILFMGIEDYATKGQKGRSDSLIVV TLDPKNKTMKMLSIPRDTRVQLAGDTTGSKTKINAAYSKGGKDETVETVENFLQIPID KYVTVDFDGFKDVINEVGGIDVDVPFDFDEKSDVDESKRIYFKKGEMHLNGEEALAYA RMRKQDKRGDFGRNDRQKQILNALIDRMSSASNIAKIDKIAEKASENVETNIRITEGL ALQQIYSGFTSKKIDTLSITGSDLYLGPNNTYYFEPDATNLEKVRKTLQEHLDYTPDT STGTSGTEDGTDSSSSSGSTGSTGTTTDGTTNGSSYSNDSSTSSNNSTTNSTTDSSY* " /label="tagV CDS" gene 3122078..3123253 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /label="tagV gene" promotor_-10 complement(3122369..3122387) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3122378) /Source="Nicolas_upshifts" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3122401..3122407) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3123225 /Source="Nicolas_upshifts" /id="D1837" /incds=0 /nref=199 /ntot=276 /MaxReadThrough="2.38202" /MaxDrop="7.1642" /score="16.6000843" /energy="-18.6" /TU="NA" /idTUdmin="U2782" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(3123326..3124402) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /EC_number="2.7.8.33" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine:undecaprenyl-P N-acetylglucosaminyl-1-P transferase" /protein_id="NP_391433.1" /db_xref="EnsemblGenomes-Gn:BSU35530" /db_xref="EnsemblGenomes-Tr:CAB15570" /db_xref="GOA:O34753" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG12684" /db_xref="UniProtKB/Swiss-Prot:O34753" /translation="MLDERMIRIVVAFIVSLLTVLIITPIVKRIAIKIGAVDQPSNRK VHDKIMPRMGGLAIFIGVVAGVLASGIYTETRMTAITVGAFIIIVLGILDDKYQLSAK VKFLIQLGVAIMIVSTGLKMDFFSVPFLTERFELGWMAYPLTVLWIVGITNAINLIDG LDGLAAGLSVIGLSTIAVMALSGGKVLILSLSLVVIASTLGFLFYNFHPAKIFMGDTG SLFLGYSISILSLLGLYKSVTLFSIVIPIIILGVPIFDTTFAIIRRILNKQPISAPDK SHIHHRLMAFGLSHRMSVLVIYLIGFIFSISAIVLKSATIWLSLFIIFILIIFMQIIA EVTGLVNEKFKPFTKFYKRLVKRN*" /label="tagO CDS" gene complement(3123326..3124402) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /label="tagO gene" downshifts complement(3123342) /Source="Nicolas_upshifts" /id="D1838" /incds=0 /nref=221 /ntot=280 /MaxReadThrough="1.7614" /MaxDrop="8.41647" /score="29.109706" /energy="-11.6" /TU="NA" /idTUdmin="U2785" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 3123388..3123397 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3123411..3123430 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3123419..3124652 /Source="Nicolas_S_feature" /locus_tag="new_3648747_3649980" /HighExp="S8, S6, S7, S5, BT, S4, B36, Pyr, S3, G/S" /AntisenseName="tagO" /AntisenseCor="-0.60515751332040901" /AntisenseRegPval="-27.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1359" upshifts 3123419 /Source="Nicolas_upshifts" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3124403..3124485) /Source="Nicolas_S_feature" /locus_tag="new_3649731_3649813_c" /HighExp="LPhT, Cold, LoTm, T0.30H, T3.0H, LBGstat, T1.30H, T1.0H, T2.30H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67123699999999997" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1360" promotor_-10 complement(3124473..3124492) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3124485) /Source="Nicolas_upshifts" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3124504..3124510) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3124547..3125740) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391434.1" /db_xref="EnsemblGenomes-Gn:BSU35540" /db_xref="EnsemblGenomes-Tr:CAB15571" /db_xref="GOA:O32267" /db_xref="SubtiList:BG12695" /db_xref="UniProtKB/Swiss-Prot:O32267" /translation="METKEAIIHVIVATAEWGKDQLRYRRHRLAEFLAAQEETKEVIW VCPAPRAQGKEFQEVHSGIRQFAVKDLLQKKMFRFGRYTDVFYRHKLSPLLDELTPAS ANGERCCLWYTFPGFPLLSSLYSWDQVIYDCSDLWAAPISGRSNLLSEFRRKVIKSAE LRIIQRADSITCSSDYLHKEVDKKLTAGREKVHTVENGVEYELFSANKQAPDRSILQG REGIVLGFIGGIKPKLDFKMIKEAALQKPDWTFLWVGPDATNGDVSFQELLRLPNVIW TGPADPKEVPHYMELIDIGIMPYKQSPYNQAVFPLKLFEFLAAGKPVVGTNLPSTSKM QKPYVYEYVEGDHPIDFIAACEKVLGQNGDETYKEMRRNIARTQDWNCLFRQIMKYTG IQKHA*" /label="tuaH CDS" gene complement(3124547..3125740) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /label="tuaH gene" downshifts complement(3124577) /Source="Nicolas_upshifts" /id="D1839" /incds=0 /nref=23 /ntot=141 /MaxReadThrough="7.20583" /MaxDrop="4.88676" /score="4.72365619" /energy="-10.8" /TU="U2786" /idTUdmin="U2785" /TUdmin="-1236" /isTUend="FALSE" /label="downshifts" CDS complement(3125769..3126527) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391435.1" /db_xref="EnsemblGenomes-Gn:BSU35550" /db_xref="EnsemblGenomes-Tr:CAB15572" /db_xref="GOA:O32268" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12694" /db_xref="UniProtKB/Swiss-Prot:O32268" /translation="MTNWKPLVSVITPSYNARDYIEDTVHSVLDQSHPHWEMIIVDDC STDGTRDILQQYEKIDERIHVVYLEENSGAAVARNKALERAQGRYVAFLDSDDKWKKD KLEKQLEFMMERSCAFSFTGYSLMAQDGTPLDKFIHAPESLTYDDALKNTIIGCLTVM IDREQTGQIQMPNIRTRQDLATWLSLLKKGFTAYGMNECLAEYRLVNNSISSNKWKAA KKTWFVYREIERLHFMKATWCFVQYAKNAVKKRL*" /label="tuaG CDS" gene complement(3125769..3126527) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /label="tuaG gene" CDS complement(3126551..3127231) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase involved in teichuronic acid synthesis" /protein_id="NP_391436.1" /db_xref="EnsemblGenomes-Gn:BSU35560" /db_xref="EnsemblGenomes-Tr:CAB15573" /db_xref="GOA:O32269" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG12693" /db_xref="UniProtKB/Swiss-Prot:O32269" /translation="MNDILIRIARRIKKNIIWIIAVPIILGAAGYILPSQIADQKSYT AEDTLAVGSYDHPVYNSTEEIPLLLKSDSFLKEALPDEKDEDVAEIKEKLTINTESKS LLTLSYSDEDKDRTESVLNAISSTFLKNDQKLYAEREAVIRSSIDALEGESVSEDSKV DKERFLYELKNTQLNLKAASVTDSETVSETAGGGMSPKKKAVLGVMIGLTIAFMFVVI PEFFRESF*" /label="tuaF CDS" gene complement(3126551..3127231) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /label="tuaF gene" CDS complement(3127260..3128726) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 15849754, 16850406, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative polymerase of teichuronic acid repeating units" /protein_id="NP_391437.1" /db_xref="EnsemblGenomes-Gn:BSU35570" /db_xref="EnsemblGenomes-Tr:CAB15574" /db_xref="GOA:O32270" /db_xref="InterPro:IPR007016" /db_xref="SubtiList:BG12692" /db_xref="UniProtKB/Swiss-Prot:O32270" /translation="MSIKRSAVHTLALLAAAIFGVVLLLGAIHKDIGFMQMAAVLAVL AIGLFLLTLATAFTTKERLFMAVIYILIACTFLNNAFFAIHLGFFSLFLYRLLLIAAG CLHIFGMVRNRTHIERWHGLQVKGILLFFAFWFIYGLVSLLWAKSVTVGLKYLALLAM GIFFIYLIVMYVQKMERLMIVYAIWLVMTVFLMIIGFYNHITHHHLASSTLYSGPEYK QHYPTSVFFNQNDFATFLSISFFFYITMMKNIKNGYIKAIGLVLSLCALYLIFATGSR ASLLGIFAGIAVYIFIVLPPVLKRMAIWLSAAGIALFAVLFASKIYSKFWELFLAPQT LHSFHDRLPSNVARANLLKNAWHFFLDSYGFGVGAGNVSYYLEHYAVYDTDNVAEVHN WLVEILANFGLFIMLGYLSVYAYLIWVLYKFYERKLENQSKLITEGLITAMVSFLVSS ISPSSVSNLFFHWVFMALVIAAVNVLRRSRQMPEPMYR*" /label="tuaE CDS" gene complement(3127260..3128726) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /label="tuaE gene" S_feature complement(3128727..3128810) /Source="Nicolas_S_feature" /locus_tag="new_3654055_3654138_c" /HighExp="LPhT, S3, B60, S7, S4, S6, LBGstat, BI, S8, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1361" CDS complement(3128811..3130196) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10376820, 10913081, 12970183, 16000785, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376820, 10913081, 12970183, 16000785, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 6-dehydrogenase (teichuronic acid)" /protein_id="NP_391438.1" /db_xref="EnsemblGenomes-Gn:BSU35580" /db_xref="EnsemblGenomes-Tr:CAB15575" /db_xref="GOA:O32271" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12691" /db_xref="UniProtKB/Swiss-Prot:O32271" /translation="MKKIAVIGTGYVGLVSGTCFAEIGNKVVCCDIDESKIRSLKNGV IPIYEPGLADLVEKNVLDQRLTFTNDIPSAIRASDIIYIAVGTPMSKTGEADLTYVKA AAKTIGEHLNGYKVIVNKSTVPVGTGKLVQSIVQKASKGRYSFDVVSNPEFLREGSAI HDTMNMERAVIGSTSHKAAAIIEELHQPFHAPVIKTNLESAEMIKYAANAFLATKISF INDIANICERVGADVSKVADGVGLDSRIGRKFLKAGIGFGGSCFPKDTTALLQIAKSA GYPFKLIEAVIETNEKQRVHIVDKLLTVMGSVKGRTISVLGLAFKPNTNDVRSAPALD IIPMLQQLGAHVKAYDPIAIPEASAILGEQVEYYTDVYAAMEDTDACLILTDWPEVKE MELVKVKTLLKQPVIIDGRNLFSLEEMQAAGYIYHSIGRPAVRGTEPSDKYFPGLPLE ELAKDLGSVNL*" /label="tuaD CDS" gene complement(3128811..3130196) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /label="tuaD gene" CDS complement(3130258..3131427) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391439.1" /db_xref="EnsemblGenomes-Gn:BSU35590" /db_xref="EnsemblGenomes-Tr:CAB15576" /db_xref="GOA:O32272" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG12690" /db_xref="UniProtKB/Swiss-Prot:O32272" /translation="MKILWITSVYPSSMKPGEGVFHETQVQELQKLGLDITVICPRPF HSAPVRMLKKTYRKKDVRPEYEIRKGIPVYRPFYRAVPGQLKWAQPHRRIASAVLKTM KQRDLYPDLIHAHFAMPSGGAAAVVSESAQIPYVLTLHGSDVNVYPHYSKGAFKAFKR AVGSASVVLAVSHKLQEEAKKLSGFDSSVLPIGIQLSRFQGNEETKEEIRKRLGLPLD QRLAVYVGRLVREKGIFELSEAIESLQDSPKAVFVGDGPAKSTLTQKGHIVTGQVPNH QVRDYLLAADLFVLPSYSEGMPTVVIEALALRVPVICTDVGGVSSLFGKHQHLLIKPK SAQALAEAITRYEHEQIWKPEVADDLYETVQAQFDAGKNAKALHHQYQTVTKTSV*" /label="tuaC CDS" gene complement(3130258..3131427) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /label="tuaC gene" CDS complement(3131424..3132875) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10048024, 11994144, 15849754, 16850406, 22720735, 26284661; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative exporter involved in biosynthesis of teichuronic acid" /protein_id="NP_391440.1" /db_xref="EnsemblGenomes-Gn:BSU35600" /db_xref="EnsemblGenomes-Tr:CAB15577" /db_xref="GOA:O32273" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG12689" /db_xref="UniProtKB/Swiss-Prot:O32273" /translation="MPSITKQIMSGAKWTSISTMCITIIQIVQFALLGNMMTLTEFGL VGMITTVTVFAQIVLDMGFGAALIQRDDATERQLSTLYWLNIMTGVLLFVLLYVSSPV IAGFYQREELVFLVRILAIMFLIAPIGQQYQYMLQKQLHFNTLSKIEIFSNVLSFGYL AIAVFMMDAILAYVISQVLLQSSKGILYWAVYRKKWHPAFVFDLRGMKDFFSFGAFQL SSRLVNRLGANIDMILIGRFIGAEALGIYNLAYQIVTIPVLKINPIVTRVAFPIFAKN KYENSVIREGFLNMTKMLALVSFPLLIGLVSVSDAFITAVFGEKWLAAVPILNVLAIV GILRVLMNPNGSVLLAKGRADLAFYWDSGVLLLYGLSLFAAVQTGSLLTVAWVYAIIS VVNFLIGRWLLAYVIKLNLSAYFQSIMKPFLITAAMGIIAFGVSLSTEHFSMQAEMRL AISVAAGALCYLFLLVKAYPQTKSKLLRKGRLS*" /label="tuaB CDS" gene complement(3131424..3132875) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /label="tuaB gene" CDS complement(3132931..3133080) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; C-terminal part of TuaA" /db_xref="SubtiList:BG12688" /translation="WAQVNGGYDMTPKEKLIFDLYYIRNLTFTLELKIMLKTCKVVWT GDGAR*" /label="tuaAc CDS" gene complement(3132931..3133080) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /pseudo /label="tuaAc gene" CDS complement(3133025..3133564) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /EC_number="2.7.8.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 10048024, 11994144, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; N-terminal part of TuaA" /translation="MSAEKSMNVSREFSVQQIHSFTLSEKTARYLAIKRVMDIWFALI GLAIALPMIAVFSILICLETPGPAIYTQERVGKGGKPFKLYKLRSMKIDAEKSGAVWA QKQDPRVTRIGAFIRRTRIDELPQLFNVLKGDMSMIGPRPERPVFTEKFQNEIPGFTQ RLGSGERRLRYDAEGKADI*" /label="tuaAn CDS" gene complement(3133025..3133564) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /pseudo /label="tuaAn gene" misc_feature complement(3133620..3133637) /Source="Nicolas_upshift_promotors" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3133624) /Source="Nicolas_upshifts" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3133791..3135281) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /EC_number="3.5.1.28" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1357079, 9537764, 14594841, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9537764, 14594841, 17298895, 19542270, 22469514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (major autolysin)" /protein_id="NP_391442.1" /db_xref="EnsemblGenomes-Gn:BSU35620" /db_xref="EnsemblGenomes-Tr:CAB15579" /db_xref="GOA:Q02114" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007253" /db_xref="SubtiList:BG10407" /db_xref="UniProtKB/Swiss-Prot:Q02114" /translation="MRSYIKVLTMCFLGLILFVPTALADNSVKRVGGSNRYGTAVQIS KQMYSTASTAVIVGGSSYADAISAAPLAYQKNAPLLYTNSDKLSYETKTRLKEMQTKN VIIVGGTPAVSSNTANQIKSLGISIKRIAGSNRYDTAARVAKAMGATSKAVILNGFLY ADAPAVIPYAAKNGYPILFTNKTSINSATTSVIKDKGISSTVVVGGTGSISNTVYNKL PSPTRISGSNRYELAANIVQKLNLSTSTVYVSNGFSYPDSIAGATLAAKKKQSLILTN GENLSTGARKIIGSKNMSNFMIIGNTPAVSTKVANQLKNPVVGETIFIDPGHGDQDSG AIGNGLLEKEVNLDIAKRVNTKLNASGALPVLSRSNDTFYSLQERVNKAASAQADLFL SIHANANDSSSPNGSETYYDTTYQAANSKRLAEQIQPKLAANLGTRDRGVKTAAFYVI KYSKMPSVLVETAFITNASDASKLKQAVYKDKAAQAIHDGTVSYYR*" /label="lytC CDS" gene complement(3133791..3135281) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /label="lytC gene" downshifts complement(3133813) /Source="Nicolas_upshifts" /id="D1840" /incds=0 /nref=145 /ntot=213 /MaxReadThrough="3.26689" /MaxDrop="6.50948" /score="13.9455176" /energy="-13.3" /TU="NA" /idTUdmin="U2788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3135320..3137437) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 16306698, 17269748" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 16306698, 17269748; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modifier of major autolysin amidase LytC" /protein_id="NP_391443.1" /db_xref="EnsemblGenomes-Gn:BSU35630" /db_xref="EnsemblGenomes-Tr:CAB15580" /db_xref="GOA:Q02113" /db_xref="InterPro:IPR007253" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="SubtiList:BG10406" /db_xref="UniProtKB/Swiss-Prot:Q02113" /translation="MKSCKQLIVCSLAAILLLIPSVSFAADSNISVKLLNYIGNKSSI SLSPTGFYKVTGDNVAVTDRFAGASRYETATLASNSQWKNPNTVILVNRDIFIDALPV IPLAKKLNAPVLFTQPDTLTKTTERQIAKFNPDNILIIGGARSISKDVENKLKSYGAV KRISGKNRYVLSENIAKQMGSYDKAIVVTGRVFQDALAIAPYAAAHGYPILLTEKDKL PDYDLPKQVIIIGSSFSVSDSVENQIKKTSTVQRIPGSTRYELTANIIKQLKLKADKV VMTNGTKYADVLIGASLASKKNSQILFVKQDSVPAAAKSITKDKATYAYDFIGSTSSI SAEVENSLADEFYLADGGTYNLKINSGKLNLENIKTYGNSLRIKPENYSTSNRISLDG KQYLGTVNFSIESTKYIRPVNENIPFEDYLKGVIPNEMPASWSLEALKAQTVAARTYS ITKTGTTVPDTTAFQVYGGYSWNSNTNKAVEQTKGKVLKYNGSLITAAYSSSNGGYTE ASNEVWSSSVPYLIAKKDTKDPQIGWTLTLSKQQLDTKSLDLTKPSSWWSSATETDSA RLSGVKNWILKNKETSADSVKIASIDDLSFSGTTQGQRAKTASMKVKYFVKSSTGSYN LSKITTISVPTSELRTMIGATVFKSTYVTVKKDTSKYTISGKGYGHGIGMSQYGAKAR AEAGDSYSSILKFYYPGTTLTSY*" /label="lytB CDS" gene complement(3135320..3137437) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /label="lytB gene" CDS complement(3137461..3137769) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1357079, 10974124, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 10974124, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="membrane bound lipoprotein" /protein_id="NP_391444.1" /db_xref="EnsemblGenomes-Gn:BSU35640" /db_xref="EnsemblGenomes-Tr:CAB15581" /db_xref="GOA:Q02112" /db_xref="SubtiList:BG10405" /db_xref="UniProtKB/Swiss-Prot:Q02112" /translation="MKKFIALLFFILLLSGCGVNSQKSQGEDVSPDSNIETKEGTYVG LADTHTIEVTVDNEPVSLDITEESTSDLDKFNSGDKVTITYEKNDEGQLLLKDIERAN *" /label="lytA CDS" gene complement(3137461..3137769) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /label="lytA gene" downshifts 3137675 /Source="Nicolas_upshifts" /id="D1841" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.03108" /MaxDrop="2.46089" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2787" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 3137765..3137769 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3137778..3137792 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3137779..3137797) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3137785 /Source="Nicolas_upshifts" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3137811..3137818) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3137814) /Source="Nicolas_upshifts" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3137835..3137843 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3137857..3137870 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3137875 /Source="Nicolas_upshifts" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="upshifts" CDS 3137953..3138873 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 9636707, 12034833, 19099556, 28197687, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9636707, 12034833, 19099556, 28197687, 29107701; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of major autolysin expression" /protein_id="NP_391445.1" /db_xref="EnsemblGenomes-Gn:BSU35650" /db_xref="EnsemblGenomes-Tr:CAB15582" /db_xref="GOA:Q02115" /db_xref="InterPro:IPR004474" /db_xref="InterPro:IPR023734" /db_xref="SubtiList:BG10404" /db_xref="UniProtKB/Swiss-Prot:Q02115" /translation="MRNERRKKKKTLLLTILTIIGLLVLGTGGYAYYLWHKAASTVAS IHESIDKSKKRDKEVSINKKDPFSVLIMGVDERDGDKGRADTLIYMTVNPKTNTTDMV SIPRDTYTKIIGKGTMDKINHSYAFGGTQMTVDTVENFLDVPVDYFVKVNMESFRDVV DTLGGITVNSTFAFSYDGYSFGKGEITLNGKEALAYTRMRKEDPRGDFGRQDRQRQVI QGIINKGANISSITKFGDMFKVVENNVKTNLTFDNMWDIQSDYKGARKHIKQHELKGT GTKINGIYYYQADESALSDITKELKESLEK*" /label="tagU CDS" gene 3137953..3138873 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /label="tagU gene" downshifts 3138863 /Source="Nicolas_upshifts" /id="D1842" /incds=0 /nref=224 /ntot=261 /MaxReadThrough="0.434639999999999" /MaxDrop="6.11301" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2789" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3138913..3140055) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /EC_number="5.1.3.14" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12107153, 16952950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12107153, 16952950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmannosamine 2-epimerase" /protein_id="NP_391446.1" /db_xref="EnsemblGenomes-Gn:BSU35660" /db_xref="EnsemblGenomes-Tr:CAB15583" /db_xref="GOA:P39131" /db_xref="InterPro:IPR003331" /db_xref="InterPro:IPR029767" /db_xref="PDB:1O6C" /db_xref="PDB:4FKZ" /db_xref="SubtiList:BG10403" /db_xref="UniProtKB/Swiss-Prot:P39131" /translation="MKKLKVMTVFGTRPEAIKMAPLVLELKKYPEIDSYVTVTAQHRQ MLDQVLDAFHIKPDFDLNIMKERQTLAEITSNALVRLDELFKDIKPDIVLVHGDTTTT FAGSLAAFYHQIAVGHVEAGLRTGNKYSPFPEELNRQMTGAIADLHFAPTGQAKDNLL KENKKADSIFVTGNTAIDALNTTVRDGYSHPVLDQVGEDKMILLTAHRRENLGEPMEN MFKAIRRIVGEFEDVQVVYPVHLNPVVREAAHKHFGDSDRVHLIEPLEVIDFHNFAAK SHFILTDSGGVQEEAPSLGKPVLVLRDTTERPEGVEAGTLKLAGTDEENIYQLAKQLL TDPDEYKKMSQASNPYGDGEASRRIVEELLFHYGYRKEQPDSFTGK*" /label="mnaA CDS" gene complement(3138913..3140055) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /label="mnaA gene" downshifts complement(3138937) /Source="Nicolas_upshifts" /id="D1843" /incds=0 /nref=126 /ntot=236 /MaxReadThrough="0.41249" /MaxDrop="5.56107" /score="7.64930656" /energy="-11" /TU="NA" /idTUdmin="U2790" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3140094..3140113) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3140108) /Source="Nicolas_upshifts" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3140128..3140131) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3140184..3140188 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3140204..3140223 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3140205..3140300 /Source="Nicolas_S_feature" /locus_tag="new_3665533_3665628" /HighExp="C90, dia5, Salt, Lbexp, T1.0H, MG 5, GM 90, MG 45, LoTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1362" upshifts 3140206 /Source="Nicolas_upshifts" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="upshifts" CDS 3140301..3141179 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2846750, 8126437, 8320212, 9658024, 17662947, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846750, 8126437, 8320212, 9658024, 17662947, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_391447.1" /db_xref="EnsemblGenomes-Gn:BSU35670" /db_xref="EnsemblGenomes-Tr:CAB15584" /db_xref="GOA:Q05852" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10402" /db_xref="UniProtKB/Swiss-Prot:Q05852" /translation="MKKVRKAIIPAAGLGTRFLPATKAMPKEMLPIVDKPTIQYIIEE AVEAGIEDIIIVTGKSKRAIEDHFDYSPELERNLEEKGKTELLEKVKKASNLADIHYI RQKEPKGLGHAVWCARNFIGDEPFAVLLGDDIVQAETPGLRQLMDEYEKTLSSIIGVQ QVPEEETHRYGIIDPLTSEGRRYQVKNFVEKPPKGTAPSNLAILGRYVFTPEIFMYLE EQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYDVGEKLGFITTTLEFAMQDKELR DQLVPFMEGLLNKEEI*" /label="gtaB CDS" gene 3140301..3141179 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /label="gtaB gene" S_feature 3141180..3142271 /Source="Nicolas_S_feature" /locus_tag="new_3666508_3667599" /HighExp="Etha, Gly, C30, M9-stat, B60, T1.30H, B36, T1.0H, M40t90, T0.30H" /AntisenseName="yvzH" /AntisenseCor="-0.24043295548020899" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1363" S_feature complement(3141249..3141604) /Source="Nicolas_S_feature" /locus_tag="new_3666577_3666932_c" /HighExp="C30, LPh, HPh, Gly, G135, HiOs, aero, GM 25, MG 25, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.74940200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig="0.996" /label="S1364" CDS 3141513..3141731 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514004.1" /translation="MATILIPLTTLLDLSRIVGLIENHGIKPASIQTIKGTSPIPVMT SLLLRIPNTNQYAIIRIRGFKTCHNTPK*" /label="hypothetical protein CDS" gene 3141513..3141731 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /label="gene" CDS complement(3141605..3141688) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative teichoic acid translocation permease protein tagG (fragment)" /db_xref="PSEUDO:CAX52700.1" /translation="MMAYWFVFGMRNSKLVITGIGEVPFIV*" /label="yvzH CDS" gene complement(3141605..3141688) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /pseudo /label="yvzH gene" S_feature complement(3141689..3141880) /Source="Nicolas_S_feature" /locus_tag="new_3667017_3667208_c" /HighExp="HPh, LPh, C30, Gly, S0, HiOs, aero, G135, Mal, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1365" CDS complement(3141881..3144583) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16735734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16735734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase" /protein_id="NP_391448.1" /db_xref="EnsemblGenomes-Gn:BSU35680" /db_xref="EnsemblGenomes-Tr:CAB15585" /db_xref="GOA:P46918" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR007554" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11192" /db_xref="UniProtKB/Swiss-Prot:P46918" /translation="MNEKSFNYDFSVIMPIYNVELYLTEAIESIINQTIGFENIQLIL VNDDSPDKSEIICKEYAQKYPNNIVYAKKQNGGVSSARNYGLKYAEGRYIQFLDPDDL VSEGTFENVLNFFDEHKNEIDIVAIPIFFAEGRTGEHNLNNKFSSTRILDVEKEPHHI LTHCCSTFIKKDALKNIRFDENCKIGEDAKLVNLIISQKKKYGLVKEAKYHYRVREDG SSAMQTAKANKNWFNHSLITFSKNLIDIIKNHEQKIPLFLQYMVMHDLKWKLLIKDIS ETPLDENEYSEFLTLIREVLSYIDDDVIIETKSVSHFYLYHALKIKHGENYSRYVYER ETEQDYYLYREGKIVSKLSDQTLTIEILEENEDSIHIEGFWSSLFNSKGFKFYAKIGE TKIKAKNIKRQHNDYISLGEVIKKYPGFSIDIPKGHLADNHHIEFFITKGKKRKLTKL RFFKYSGLSNDLYNTYVAKKDYIFYYNYKKLMFKKNNFKNRFIKEFRFLKSLHKSGEK SKKRKSAIKKALMARMVHHVFTIFNRKPVWLFIDRQDKADDNAEHLFKYAINKNDGVK KYFIIKKDSKDYDRIKKYGKVIPYRSFRHKILTLSSSKVISTHADIWVVNPFFNMEIY FRDLFNFEFIFLQHGITMADHSEWLNKYNKNIKLLVTSAKPEYRSIVKGNYNYKKENI LLGGFPRYDNLKKSEGEKQLLIMPTWRKDIVLPKDQAKGVRPYNPKFKDSEYFSRYNA LINDERLIEFAKKNNYKITFFPHPDIQQQIVDFEKHDYVEFADYNSSYQMLFNSSNIM ITDFSSVAFDFAYEKKPVIYYQYEKSYHFKLDYYDYKKMGFGDVLENHNSLVDKVIYY MKNNSRMEDKYRKRVDNFFAYTDKNNRNRIYNAILELDNNKVAK*" /label="ggaB CDS" gene complement(3141881..3144583) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /label="ggaB gene" S_feature complement(3144584..3144706) /Source="Nicolas_S_feature" /locus_tag="new_3669912_3670034_c" /HighExp="BMM, HiOs, MG 15, C30, SMM, GM 90, HPh, MG 150, MG 25, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1366" promotor_-35 3144605..3144611 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3144626..3144644 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3144631..3147463 /Source="Nicolas_S_feature" /locus_tag="new_3669959_3672791" /HighExp="Sw, LoTm, M9-stat, Salt, B60, T0.30H, Gly, T1.0H, B36, BI" /AntisenseName="ggaA" /AntisenseCor="-0.503651102561819" /AntisenseRegPval="-18" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1367" upshifts 3144631 /Source="Nicolas_upshifts" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3144707..3146047) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16735734, 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase (missing signal peptide)" /db_xref="EnsemblGenomes-Gn:BSU35690" /db_xref="EnsemblGenomes-Tr:CAB15586" /db_xref="GOA:P46917" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PSEUDO:CAB15586.1" /db_xref="SubtiList:BG11367" /db_xref="UniProtKB/Swiss-Prot:P46917" /translation="MFSIIIPIYNSENYLRYSIESVLNQSIGFKENIELILIDDGSVD SSPQICESFKNLYPNNIKIMKIENSGPSAARNCGLSNVSERSKFIGFLDSDDAFSQNA LQSVYDFFCDSEHVNIAVLPVYYTGEKEGGHKLNNRFEKGTRVINILNDYKAIHFYIG GTFYRRHTLTSTVLFDESIKFWEDAIFFNQLLLKEKRYGAVAEGKYFYRKRKEQDSLV DRSWFNKKRYTYLLNECYMTLLMDSFNKYDIVLPYLQFLIVYHIKLFLYPNYRDVYKS VLDQQEQRVFVDDFIKVLKFIDPQFIKEQDMPMYYKEFMFHLLKENTEALENIKKERV LHSSCTVTSAKIKGLRLELTGHFINQYYEMKENDRIYIKYFKRLKKCKRKELKKTIEV WGYKLRDFRYAGFVVEIPIWAFAFDFVLKTPNDSLELNHVNIFKSLLTRVFKKR*" /label="ggaA CDS" gene complement(3144707..3146047) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /pseudo /label="ggaA gene" CDS complement(3146088..3146294) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /EC_number="2.7.8.12" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (fragment)" /db_xref="PSEUDO:CAX52701.1" /translation="MYDLPAYRDCIRGFYFNFQQKTPGNLLQTSEELIDTVKELLHNP YIDHNYEDFYNKFCNLEEARLLKE*" /label="yvzI CDS" gene complement(3146088..3146294) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /pseudo /label="yvzI gene" S_feature complement(3146295..3147168) /Source="Nicolas_S_feature" /locus_tag="new_3671623_3672496_c" /HighExp="HiOs, Heat, BMM, MG 15, GM 90, MG 25, MG 150, C30, GM 25, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99943499999999996" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1368" promotor_-10 complement(3147162..3147181) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3147168) /Source="Nicolas_upshifts" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3147170..3147409) /Source="Nicolas_S_feature" /locus_tag="new_3672498_3672737_c" /HighExp="Cold, LBGstat, C30, GM 25, GM 15, GM 45, GM 60, GM 10, GM-0.2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1369" promotor_-35 complement(3147194..3147200) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3147391..3147409) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-10" upshifts complement(3147409) /Source="Nicolas_upshifts" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="upshifts" promotor_-35 complement(3147423..3147430) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-35" promotor_-35 3147432..3147439 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3147451..3147470 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3147465..3147595 /Source="Nicolas_S_feature" /locus_tag="new_3672793_3672923" /HighExp="Sw, T0.30H, LoTm, B60, T1.0H, Lbtran, C30, LBGtran, dia5, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1370" upshifts 3147465 /Source="Nicolas_upshifts" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3147537..3147637 /Source="Nicolas_upshift_promotors" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3147597 /Source="Nicolas_upshifts" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS 3147601..3148197 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /EC_number="2.7.7.9" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase) (UDPGP) (fragment)" /db_xref="PSEUDO:CAX52702.1" /translation="MISFFHYILQKEPKGLGHAVWFAPNFIGDEPFAFLLGDDIVQAD TPGLRQLTDEYERTLSSIIGVQQVPEDETHCYGIIAPLTSEGRRYQVKNFIEKPPKDT APSNLAILGRYVFTPEIFMYLEEQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYD VGEKLGFITTTLEFAMQDKELRDQLVPFMEGLLNKEEI*" /label="yvzE CDS" gene 3147601..3148197 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /pseudo /label="yvzE gene" downshifts 3147795 /Source="Nicolas_upshifts" /id="D1844" /incds=1 /nref=94 /ntot=183 /MaxReadThrough="4.62614" /MaxDrop="5.15039" /score="34.2325445" /energy="-14.3" /TU="U2792,U2795" /idTUdmin="U2796" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3148236..3149819) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /EC_number="3.6.3.40" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 17012386, 18156271; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding teichoic acid precursor transporter component" /protein_id="NP_391451.1" /db_xref="EnsemblGenomes-Gn:BSU35700" /db_xref="EnsemblGenomes-Tr:CAB15587" /db_xref="GOA:P42954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015860" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030284" /db_xref="SubtiList:BG11191" /db_xref="UniProtKB/Swiss-Prot:P42954" /translation="MKLKVSFRNVSKQYHLYKKQSDKIKGLFFPAKDNGFFAVRNVSF DVYEGETIGFVGINGSGKSTMSNLLAKIIPPTSGEIEMNGQPSLIAIAAGLNNQLTGR DNVRLKCLMMGLTNKEIDDMYDSIVEFAEIGDFINQPVKNYSSGMKSRLGFAISVHID PDILIIDEALSVGDQTFYQKCVDRINEFKKQGKTIFFVSHSIGQIEKMCDRVAWMHYG ELRMFDETKTVVKEYKAFIDWFNKLSKKEKETYKKEQTEERKKEDPEAFARFRKKKKK PKSLANAIQIAILSILTVFMAGTMFFNAPLRTIASFGAIPQNEVKNHHGDAKGKSEER LTAINKQGFIANEKAAAYKDQGLKQKADVTLPFGTKVTVAAKGKQAAKIKFDGHSYYV KQSAVATNMKHAELHATAFTSYVSQNAASSYEYFLKFLGDSSTSIQSKLNGYTEGNKA DGRKTLNFDYEKISYVLENDKATELIFHNISPINPASLSLSDSDVLYDSSKKRFLVNT DDQVFAVDNEEHTLTLMLK*" /label="tagH CDS" gene complement(3148236..3149819) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /label="tagH gene" downshifts 3148279 /Source="Nicolas_upshifts" /id="D1845" /incds=0 /nref=2 /ntot=19 /MaxReadThrough="1.20059" /MaxDrop="5.25978" /score="34.2325445" /energy="-14.3" /TU="NA" /idTUdmin="U2792" /TUdmin=440 /isTUend="FALSE" /label="downshifts" CDS complement(3149839..3150666) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 15849754, 16850406, 17012386, 18156271, 27213893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="teichoic acid precursors permease" /protein_id="NP_391452.1" /db_xref="EnsemblGenomes-Gn:BSU35710" /db_xref="EnsemblGenomes-Tr:CAB15588" /db_xref="GOA:P42953" /db_xref="InterPro:IPR000412" /db_xref="InterPro:IPR013525" /db_xref="SubtiList:BG11205" /db_xref="UniProtKB/Swiss-Prot:P42953" /translation="MNDLLRILREQITSFPLILRLAAYETKSKYQMNYLGVLWQFLNP LIQMLAYWFVFGMGIRKGGPVTTGAGEVPFIIWMLAGLIPWFFISPTILDGSNSVFKR INMVAKMNFPISSLPSVAIASNLFSYMIMMVIYIIVLLVNGVFPSVHWLQYIYYFICM IAFMFSFSLFNSTISVLIRDYQFLLQAVTRLLFFLLPIFWDVNAKLGQSHPELVPVLK LNPLFYIIEGFRNSFLDGAWFFHDMKYTLYFWLFTFLLLLVGSILHMKFRDKFVDFL* " /label="tagG CDS" gene complement(3149839..3150666) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /label="tagG gene" S_feature complement(3150667..3150731) /Source="Nicolas_S_feature" /locus_tag="new_3675995_3676059_c" /HighExp="H2O2, LBGstat, dia15, Oxctl, LBGexp, G150, Paraq, G180, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1371" promotor_-10 complement(3150727..3150746) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3150731) /Source="Nicolas_upshifts" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3150733..3150830) /Source="Nicolas_S_feature" /locus_tag="new_3676061_3676158_c" /HighExp="G180, G135, Cold, G150, LPh, S0, Oxctl, Paraq, HPh, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1372" promotor_-35 complement(3150762..3150765) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3150831..3153071) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /EC_number="2.7.8.12" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase (poly(glycerol phosphate) polymerase)" /protein_id="NP_391453.1" /db_xref="EnsemblGenomes-Gn:BSU35720" /db_xref="EnsemblGenomes-Tr:CAB15589" /db_xref="GOA:P13485" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10725" /db_xref="UniProtKB/Swiss-Prot:P13485" /translation="MSLVVDTNKRKQKGKSFYTEEQKKVMIENTVIKCILKSLKNNLG SLELLISIDSEHQFLEDYQLFLKLKERRSGTESEFPLQNTGSLEYKTEINAHVLPMPV EMGQTYDFYVEFRKKYEDAEQEPLLKRLSAEVNSIERAFHVDQTTELLILPYTTDKGN FSIKVKREAKIIRFDQIEISSEEISITGYAGYLSSENQYRIKNLNLILKKGGETPIEE KFPIKLERKTHGLENMRADGFVPELYDFEVKVPLKEIPFSNEKRYVYRLFMEYICNDD EGTDIQFNSTALVLGDRKNKLKGLVSIIKTNNAPVRYEVFKKKKKQTLGIRVNDYSLK TRMKYFIKGKKKRLVSKIKKITKMRNKLITKTYKSLFMMASRMPVKRKTVIFESFNGK QYSCNPRAIYEYMRENHPEYKMYWSVNKQYSAPFDEKGIPYINRLSLKWLFAMARAEY WVVNSRLPLWIPKPSHTTYLQTWHGTPLKRLAMDMEEVHMPGTNTKKYKRNFIKEASN WDYLISPNGYSTEIFTRAFQFNKTMIESGYPRNDFLHNDNNEETISLIKSRLNIPRDK KVILYAPTWRDDQFYAKGRYKFDLDLDLHQLRQELGNEYIVILRMHYLVAENFDLGPF EGFAYDFSAYEDIRELYMVSDLLITDYSSVFFDFANLKRPMLFFVPDIETYRDKLRGF YFDFEKEAPGPLVKTTEETIEAIKQISSPDYKLPVSFGPFYDKFCYLESGRSSEKVVN TVFKAE*" /label="tagF CDS" gene complement(3150831..3153071) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /label="tagF gene" CDS complement(3153071..3155092) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /EC_number="2.4.1.52" /function="16.8: Protect" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose:polyglycerol phosphate alpha-glucosyltransferase" /protein_id="NP_391454.1" /db_xref="EnsemblGenomes-Gn:BSU35730" /db_xref="EnsemblGenomes-Tr:CAB15590" /db_xref="GOA:P13484" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR015397" /db_xref="SubtiList:BG10724" /db_xref="UniProtKB/Swiss-Prot:P13484" /translation="MSLHAVSESNIKQIPDMDYYFISGGLPSNYGGLTKSLLLRSKLF GEECNQNTFFLTFRFDLELSSKIDELYSNGKIDKKFTSVINLFDDFLSVRTNGKRSYE ERIGLDQIKKQVGMGKFAKTLLRLFGKKNNEMSVVYYGDGETIRYVDYWNDKNQLIKR EEYTKNGNLVLVTHYDVQLNKMYLQEYINDQNQVYLDKLYVWNNEEKDVQLSHIIWYS LEGEIKVKDESELRQYWIEYLQKQNDKPKLFLVDSRPQDKHVFKVKKSPSSYYGAIIH NKHYGSNKYQIKGRYKEVFSQMYNLDAVFFITEEQLEDFKLISGEQETFFFTPHTIDK PLDPAVLNVPSEKYKAVIISRLASMKNLIHAVKAFSLVVKEIPEAKLDIFGSGEDFEK IKKEIEDTKLQNNVFLKGYTDNPDSEFQKAWLTISTSHFEGFGLSNMEALSNGCPVVT YDYDYGARSLVTDGANGYVIEQYNIEKLGQAIISLMKDESTHQKFSEQAFKMAEKYSR PNYIENWAFALNQMIEVRIEREKFSKKVGKKDPSISSYTEDFDKTKIEIDIENFDHND IKKIRLVGLDRKNKAEIISTNLQNDQLFVIDLEKDVNIEKIAANKTQVIDFYIVFNAN GHIKTMRRLSSEETKLSGNSIDTNNGYRVEPYTTVKGNFSWRVTEIKES*" /label="tagE CDS" gene complement(3153071..3155092) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /label="tagE gene" promotor_-35 3153834..3153843 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3153856..3153871 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3153867 /Source="Nicolas_upshifts" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3155093..3155252) /Source="Nicolas_S_feature" /locus_tag="new_3680421_3680580_c" /HighExp="G180, G135, Cold, G150, Oxctl, LBGexp, Paraq, Lbexp, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1373" CDS complement(3155253..3155642) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /EC_number="2.7.7.39" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol-3-phosphate cytidylyltransferase" /protein_id="NP_391455.1" /db_xref="EnsemblGenomes-Gn:BSU35740" /db_xref="EnsemblGenomes-Tr:CAB15591" /db_xref="GOA:P27623" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR006409" /db_xref="InterPro:IPR014729" /db_xref="PDB:1COZ" /db_xref="PDB:1N1D" /db_xref="SubtiList:BG10449" /db_xref="UniProtKB/Swiss-Prot:P27623" /translation="MKKVITYGTFDLLHWGHIKLLERAKQLGDYLVVAISTDEFNLQK QKKAYHSYEHRKLILETIRYVDEVIPEKNWEQKKQDIIDHNIDVFVMGDDWEGKFDFL KDQCEVVYLPRTEGISTTKIKEEIAGL*" /label="tagD CDS" gene complement(3155253..3155642) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /label="tagD gene" S_feature complement(3155643..3155777) /Source="Nicolas_S_feature" /locus_tag="new_3680971_3681105_c" /HighExp="BC, Cold, T3.0H, HiOs, MG-0.2, T1.30H, T3.30H, LPhT, MG 15, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1374" promotor_-10 complement(3155761..3155780) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3155777) /Source="Nicolas_upshifts" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3155791..3155798) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3155932..3155938 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3155949..3156041 /Source="Nicolas_S_feature" /locus_tag="new_3681277_3681369" /HighExp="B60, LoTm, Cold, T3.30H, T3.0H, Salt, T5.0H, T4.0H, Lbexp, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1375" upshifts 3155949 /Source="Nicolas_upshifts" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3155950..3155969 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3156042..3156812 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /EC_number="2.4.1.187" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmannosamine (ManNAc) C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid (GlcNAc-pp-undecaprenyl, lipid I) glycosyltransferase" /protein_id="NP_391456.1" /db_xref="EnsemblGenomes-Gn:BSU35750" /db_xref="EnsemblGenomes-Tr:CAB15592" /db_xref="GOA:P27620" /db_xref="InterPro:IPR004629" /db_xref="InterPro:IPR034714" /db_xref="SubtiList:BG10450" /db_xref="UniProtKB/Swiss-Prot:P27620" /translation="MQTETIHNIPYVNSNLTSFIDYLEKHYIDQKIGAVISTVNPEIA FAAIKDRDYFDVLSSSNFILPDGIGVVMMSRLTNNRLQSRIAGYDVFKELLGVANKKK KRIFLYGAKKDVIKGVVSKISSEYPNIKIAGYSDGYVQDRTLVAKQIARANPDMVFVA LGYPHQEKFIHNYRHLFPKAVSIGLGGSFDVFSGNVKRAPSWMIRLNLEWFYRLILNP WRWKRMLSIPKYALTVLKEEKNKKTFYPKPEKDHTKQI*" /label="tagA CDS" gene 3156042..3156812 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /label="tagA gene" S_feature complement(3156169..3156517) /Source="Nicolas_S_feature" /locus_tag="new_3681497_3681845_c" /HighExp="S8, S6, S7, S5, S4, G135, S3, C30, G180, ferm" /AntisenseName="tagA" /AntisenseCor="-0.35014495927301897" /AntisenseRegPval="-8.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1376" promotor_-10 complement(3156521..3156532) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3156525) /Source="Nicolas_upshifts" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3156547..3156553) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3156837 /Source="Nicolas_upshifts" /id="D1846" /incds=0 /nref=2 /ntot=103 /MaxReadThrough="6.64821" /MaxDrop="3.225" /score="-6.01444425" /energy="-10.9" /TU="U2800" /idTUdmin="U2800" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" CDS 3156845..3157990 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /EC_number="2.7.8.44" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid primase, CDP-glycerol:N-acetyl-beta-d-mannosaminyl-1, 4-N-acetyl-d-glucosaminyldiphosphoundecaprenyl glycerophosphotransferase" /protein_id="NP_391457.1" /db_xref="EnsemblGenomes-Gn:BSU35760" /db_xref="EnsemblGenomes-Tr:CAB15593" /db_xref="GOA:P27621" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10451" /db_xref="UniProtKB/Swiss-Prot:P27621" /translation="MKIRSLLANCYLYFLSAIAFFLQWVKPESKVTLLISFEANAKAI LEEYEQGQYSYKLNILYTQQASAIAESFPNVDAYLLQEKNPIHLIKAVYLMFNSKVII TDNYFLLTSVLNKRKQTKCIQVWHANGSLKKFGLEDITNMQRTKTDIKRFQKVYSSYD YLTVGSEEMANIFKKSFGIKDNQLLKIGVPLTDPYYRENKKKISDTLNIQRKKIILYA PTFRDYNMQSIQLPFTEEQLIHQLKEEYVLFVKLHPAIQNNIDIKYSSDYIKDVSNYA LFDLLMAADILITDYSSVPFEFSILNKPILFYTYDLKLYQQKRGLVDNYLSIIPGRAC YDSESLINEIQTPFNYSKIKVFSDRWNKYSDGNSSQNLLNFIENLIS*" /label="tagB CDS" gene 3156845..3157990 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /label="tagB gene" downshifts 3157978 /Source="Nicolas_upshifts" /id="D1847" /incds=0 /nref=101 /ntot=235 /MaxReadThrough="3.54908" /MaxDrop="5.95551" /score="-3.22062454" /energy="-10" /TU="U2800" /idTUdmin="U2800" /TUdmin="-1169" /isTUend="FALSE" /label="downshifts" promotor_-35 3158032..3158039 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3158054..3158073 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3158064 /Source="Nicolas_upshifts" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="upshifts" CDS 3158110..3159438 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7952180, 16269821; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polyglycerol phosphate assembly and export protein (teichoic acid biosynthesis)" /protein_id="NP_391458.1" /db_xref="EnsemblGenomes-Gn:BSU35770" /db_xref="EnsemblGenomes-Tr:CAB15594" /db_xref="GOA:P27622" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG10453" /db_xref="UniProtKB/Swiss-Prot:P27622" /translation="MRKKELFDFTNITPKLFTELRVADKTVLQSFNFDEKNHQIYTTQ VASGLGKDNTQSYRITRLSLEGLQLDSMLLKHGGHGTNIGIENRNGTIYIWSLYDKPN ETDKSELVCFPYKAGATLDENSKELQRFSNMPFDHRVTPALDMKNRQLAIRQYDTKNN NNKQWVTIFNLDDAIANKNNPLYTINIPDELHYLQGFFLDDGYLYWYTGDTNSKSYPN LITVFDSDNKIVLQKEITVGKDLSTRYENNFREPEGICMYTNPETGAKSLMVGITSGK EGNRISRIYAYHSYENFMNHVPMLRSPLLKTVGHQDTPPERFQPFIQTFILEYNAQNK KWMVPTSGYLPSYTSNLVRNITINADGNLQVTLNERYISLLHQSIEGDFRLKQKDIRM GSWYFAGGEKSNVLEIGFMKGSTKIRPDDAAISNASRMSIFMIVADKIEV*" /label="tagC CDS" gene 3158110..3159438 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /label="tagC gene" downshifts 3159433 /Source="Nicolas_upshifts" /id="D1848" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.77356" /MaxDrop="4.002" /score="-7.52215775" /energy="-19.3" /TU="NA" /idTUdmin="U2802" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3159494) /Source="Nicolas_upshifts" /id="D1849" /incds=0 /nref=141 /ntot=248 /MaxReadThrough="0.94732" /MaxDrop="5.40128" /score="-0.11635468" /energy="-19.3" /TU="NA" /idTUdmin="U2803" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" SCAR 3159518..3159519 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_002" downshifts 3159542 /Source="Nicolas_upshifts" /id="D1854" /incds=0 /nref=163 /ntot=235 /MaxReadThrough="3.35965" /MaxDrop="5.65658" /score="24.125299" /energy="-9.8" /TU="NA" /idTUdmin="U2809" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3159595..3160836) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /EC_number="3.4.19.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12073126, 12644511, 16689787, 16952838, 26158264, 28664519" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073126, 12644511, 16689787, 16952838, 26158264, 28664519; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-DD-glutamyl hydrolase (PGA depolymerase)" /protein_id="NP_391467.1" /db_xref="EnsemblGenomes-Gn:BSU35860" /db_xref="EnsemblGenomes-Tr:CAB15603" /db_xref="GOA:P96740" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG12535" /db_xref="UniProtKB/Swiss-Prot:P96740" /translation="MNTLANWKKFLLVAVIICFLVPIMTKAEIAEADTSSELIVSEAK NLLGYQYKYGGETPKEGFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPENLKPGD ILFFKKEGSTGTVPTHDALYIGDGQMVHSTQSKGVIITNYKKSSYWSGTYIGARRIAA DPATADVPVVQEAEKYIGVPYVFGGSTPSEGFDCSGLVQYVFQQALGIYLPRSAEQQW AVGEKVAPQNIKPGDVVYFSNTYKTGISHAGIYAGAGRFIQASRSEKVTISYLSEDYW KSKMTGIRRFDNLTIPKENPIVSEATLYVGEVPYKQGGVTPETGFDTAGFVQYVYQKA AGISLPRYATSQYNAGTKIEKADLKPGDIVFFQSTSLNPSIYIGNGQVVHVTLSNGVT ITNMNTSTYWKDKYAGSIRVQ*" /label="pgdS CDS" gene complement(3159595..3160836) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /label="pgdS gene" downshifts complement(3159614) /Source="Nicolas_upshifts" /id="D1855" /incds=0 /nref=228 /ntot=317 /MaxReadThrough="2.27329" /MaxDrop="7.15996" /score="10.2499259" /energy="-9.8" /TU="NA" /idTUdmin="U2812" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3160858..3160876) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3160880) /Source="Nicolas_upshifts" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3160889..3160896) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3160977..3161144) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16267300, 16689787, 20812257, 21357437, 23583563, 25843804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267300, 16689787, 20812257, 21357437, 23583563, 25843804; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor required extrachromosomal elements maintenance" /protein_id="NP_391468.1" /db_xref="EnsemblGenomes-Gn:BSU35870" /db_xref="EnsemblGenomes-Tr:CAB15604" /db_xref="SubtiList:BG12534" /db_xref="UniProtKB/Swiss-Prot:P96739" /translation="MKFVKAIWPFVAVAIVFMFMSAFKFNDQLTDQEKQKIDMEMNKI QQQEEPVNANK*" /label="edmS CDS" gene complement(3160977..3161144) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /label="edmS gene" downshifts complement(3161004) /Source="Nicolas_upshifts" /id="D1856" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="0.6752" /MaxDrop="2.78178" /score="24.9141523" /energy="-14.7" /TU="NA" /idTUdmin="U2812" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" CDS complement(3161159..3162301) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /EC_number="6.3.2.-" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 12644511, 16689787, 19745567, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 12644511, 16689787, 19745567, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (acid resistance)" /protein_id="NP_391469.1" /db_xref="EnsemblGenomes-Gn:BSU35880" /db_xref="EnsemblGenomes-Tr:CAB15605" /db_xref="InterPro:IPR019079" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12533" /db_xref="UniProtKB/Swiss-Prot:P96738" /translation="MKKELSFHEKLLKLTKQQKKKTNKHVFIAIPIVFVLMFAFMWAG KAETPKVKTYSDDVLSASFVGDIMMGRYVEKVTEQKGADSIFQYVEPIFRASDYVAGN FENPVTYQKNYKQADKEIHLQTNKESVKVLKDMNFTVLNSANNHAMDYGVQGMKDTLG EFAKQNLDIVGAGYSLSDAKKKISYQKVNGVTIATLGFTDVSGKGFAAKKNTPGVLPA DPEIFIPMISEAKKHADIVVVQSHWGQEYDNDPNDRQRQLARAMSDAGADIIVGHHPH VLEPIEVYNGTVIFYSLGNFVFDQGWTRTRDSALVQYHLKKNGTGRFEVTPIDIHEAT PAPVKKDSLKQKTIIRELTKDSNFAWKVEDGKLTFDIDHSDKLKSK*" /label="capA CDS" gene complement(3161159..3162301) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /label="capA gene" CDS complement(3162320..3162769) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 15849754, 16689787, 16850406, 19734658" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 15849754, 16689787, 16850406, 19734658; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate amide ligase/translocase subunit" /protein_id="NP_391470.1" /db_xref="EnsemblGenomes-Gn:BSU35890" /db_xref="EnsemblGenomes-Tr:CAB15606" /db_xref="GOA:P96737" /db_xref="InterPro:IPR008338" /db_xref="SubtiList:BG12532" /db_xref="UniProtKB/Swiss-Prot:P96737" /translation="MFGSDLYIALILGVLLSLIFAEKTGIVPAGLVVPGYLGLVFNQP VFILLVLLVSLLTYVIVKYGLSKFMILYGRRKFAAMLITGIVLKIAFDFLYPIVPFEI AEFRGIGIIVPGLIANTIQKQGLTITFGSTLLLSGATFAIMFVYYLI*" /label="capC CDS" gene complement(3162320..3162769) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /label="capC gene" promotor_-35 3162463..3162469 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-35" upshifts 3162477 /Source="Nicolas_upshifts" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="upshifts" promotor_-10 3162483..3162501 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-10" S_feature 3162490..3164699 /Source="Nicolas_S_feature" /locus_tag="new_3699152_3701361" /HighExp="Sw, Salt, dia5, BC, B60, Diami, Lbstat, H2O2, dia15, Gly" /AntisenseName="pgsB" /AntisenseCor="7.6745622610153399E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="0.40410200000000002" /TUshortSig="SigB" /TUshortPSig="0.853" /TUlongSig="NA" /TUlongPSig="NA" /label="S1382" CDS complement(3162784..3163965) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11606194, 11751809, 12644511, 16689787, 19420703, 19734658, 27446033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (ATP-dependentamide ligase)" /protein_id="NP_391471.2" /db_xref="EnsemblGenomes-Gn:BSU35900" /db_xref="EnsemblGenomes-Tr:CAB15607" /db_xref="GOA:P96736" /db_xref="InterPro:IPR008337" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="SubtiList:BG12531" /db_xref="UniProtKB/Swiss-Prot:P96736" /translation="MWLLIIACAVILVIGILEKRRHQKNIDALPVRVNINGIRGKSTV TRLTTGILIEAGYKTVGKTTGTDARMIYWDTPEEKPIKRKPQGPNIGEQKEVMRETVE RGANAIVSECMAVNPDYQIIFQEELLQANIGVIVNVLEDHMDVMGPTLDEIAEAFTAT IPYNGHLVITDSEYTEFFKQKAKERNTKVIIADNSKITDEYLRKFEYMVFPDNASLAL GVAQALGIDEETAFKGMLNAPPDPGAMRILPLISPSEPGHFVNGFAANDASSTLNIWK RVKEIGYPTDDPIIIMNCRADRVDRTQQFANDVLPYIEASELILIGETTEPIVKAYEE GKIPADKLHDLEYKSTDEIMELLKKRMHNRVIYGVGNIHGAAEPLIEKIHEYKVKQLV S*" /label="capB CDS" gene complement(3162784..3163965) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /label="capB gene" promotor_-35 3164679..3164686 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3164701 /Source="Nicolas_upshifts" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3164702..3164721 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3164722) /Source="Nicolas_upshifts" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3164727..3164741) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3164749..3164753) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3164749..3165729 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11750820, 16519689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11750820, 16519689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="ribose operon repressor (LacI family, D-ribose)" /protein_id="NP_391472.1" /db_xref="EnsemblGenomes-Gn:BSU35910" /db_xref="EnsemblGenomes-Tr:CAB15608" /db_xref="GOA:P36944" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10876" /db_xref="UniProtKB/Swiss-Prot:P36944" /translation="MATIKDVAGAAGVSVATVSRNLNDNGYVHEETRTRVIAAMAKLN YYPNEVARSLYKRESRLIGLLLPDITNPFFPQLARGAEDELNREGYRLIFGNSDEELK KELEYLQTFKQNHVAGIIAATNYPDLEEYSGMNYPVVFLDRTLEGAPSVSSDGYTGVK LAAQAIIHGKSQRITLLRGPAHLPTAQDRFNGALEILKQAEVDFQVIETASFSIKDAQ SMAKELFASYPATDGVIASNDIQAAAVLHEALRRGKNVPEDIQIIGYDDIPQSGLLFP PLSTIKQPAYDMGKEAAKLLLGIIKKQPLAETAIQMPVTYIGRKTTRKED*" /label="rbsR CDS" gene 3164749..3165729 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /label="rbsR gene" promotor_-35 3165578..3165585 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3165599..3165618 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3165614 /Source="Nicolas_upshifts" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" CDS 3165731..3166612 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /EC_number="2.7.1.15" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 16978644; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribokinase" /protein_id="NP_391473.1" /db_xref="EnsemblGenomes-Gn:BSU35920" /db_xref="EnsemblGenomes-Tr:CAB15609" /db_xref="GOA:P36945" /db_xref="InterPro:IPR002139" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR011877" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG10877" /db_xref="UniProtKB/Swiss-Prot:P36945" /translation="MRNICVIGSCSMDLVVTSDKRPKAGETVLGTSFQTVPGGKGANQ AVAAARLGAQVFMVGKVGDDHYGTAILNNLKANGVRTDYMEPVTHTESGTAHIVLAEG DNSIVVVKGANDDITPAYALNALEQIEKVDMVLIQQEIPEETVDEVCKYCHSHDIPII LNPAPARPLKQETIDHATYLTPNEHEASILFPELTISEALALYPAKLFITEGKQGVRY SAGSKEVLIPSFPVEPVDTTGAGDTFNAAFAVALAEGKDIEAALRFANRAASLSVCSF GAQGGMPTRNEVEELLS*" /label="rbsK CDS" gene 3165731..3166612 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /label="rbsK gene" CDS 3166609..3167004 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /EC_number="5.4.99.62" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 12738765, 21276853; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose pyranase" /protein_id="NP_391474.1" /db_xref="EnsemblGenomes-Gn:BSU35930" /db_xref="EnsemblGenomes-Tr:CAB15610" /db_xref="GOA:P36946" /db_xref="InterPro:IPR007721" /db_xref="InterPro:IPR023064" /db_xref="InterPro:IPR023750" /db_xref="PDB:1OGC" /db_xref="PDB:1OGD" /db_xref="PDB:1OGE" /db_xref="PDB:1OGF" /db_xref="SubtiList:BG10878" /db_xref="UniProtKB/Swiss-Prot:P36946" /translation="MKKHGILNSHLAKILADLGHTDKIVIADAGLPVPDGVLKIDLSL KPGLPAFQDTAAVLAEEMAVEKVIAAAEIKASNQENAKFLENLFSEQEIEYLSHEEFK LLTKDAKAVIRTGEFTPYANCILQAGVLF*" /label="rbsD CDS" gene 3166609..3167004 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /label="rbsD gene" CDS 3167020..3168501 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ATP-binding protein)" /protein_id="NP_391475.1" /db_xref="EnsemblGenomes-Gn:BSU35940" /db_xref="EnsemblGenomes-Tr:CAB15611" /db_xref="GOA:P36947" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015861" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10879" /db_xref="UniProtKB/Swiss-Prot:P36947" /translation="MQIEMKDIHKTFGKNQVLSGVSFQLMPGEVHALMGENGAGKSTL MNILTGLHKADKGQISINGNETYFSNPKEAEQHGIAFIHQELNIWPEMTVLENLFIGK EISSKLGVLQTRKMKALAKEQFDKLSVSLSLDQEAGECSVGQQQMIEIAKALMTNAEV IIMDEPTAALTEREISKLFEVITALKKNGVSIVYISHRMEEIFAICDRITIMRDGKTV DTTNISETDFDEVVKKMVGRELTERYPKRTPSLGDKVFEVKNASVKGSFEDVSFYVRS GEIVGVSGLMGAGRTEMMRALFGVDRLDTGEIWIAGKKTAIKNPQEAVKKGLGFITEN RKDEGLLLDTSIRENIALPNLSSFSPKGLIDHKREAEFVDLLIKRLTIKTASPETHAR HLSGGNQQKVVIAKWIGIGPKVLILDEPTRGVDVGAKREIYTLMNELTERGVAIIMVS SELPEILGMSDRIIVVHEGRISGEIHAREATQERIMTLATGGR*" /label="rbsA CDS" gene 3167020..3168501 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /label="rbsA gene" CDS 3168503..3169471 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (permease)" /protein_id="NP_391476.1" /db_xref="EnsemblGenomes-Gn:BSU35950" /db_xref="EnsemblGenomes-Tr:CAB15612" /db_xref="GOA:P36948" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10880" /db_xref="UniProtKB/Swiss-Prot:P36948" /translation="MKTEQLQTEQKRIHFDGVMQKLGPFLGLFILVIIVSILNPSFLE PLNILNLLRQVAINGLIAFGMTFVILTGGIDLSVGAILALSSALVAGMIVSGVDPVLA IILGCIIGAVLGMINGLLITKGKMAPFIATLATMTVFRGLTLVYTDGNPITGLGTNYG FQMFGRGYFLGIPVPAITMVLAFVILWVLLHKTPFGRRTYAIGGNEKAALISGIKVTR VKVMIYSLAGLLSALAGAILTSRLHSAQPTAGESYELDAIAAVVLGGTSLSGGRGRIV GTLIGVLIIGTLNNGLNLLGVSSFYQLVVKGIVILIAVLLDRKKSA*" /label="rbsC CDS" gene 3168503..3169471 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /label="rbsC gene" CDS 3169483..3170400 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ribose-binding lipoprotein)" /protein_id="NP_391477.1" /db_xref="EnsemblGenomes-Gn:BSU35960" /db_xref="EnsemblGenomes-Tr:CAB15613" /db_xref="GOA:P36949" /db_xref="InterPro:IPR025997" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10881" /db_xref="UniProtKB/Swiss-Prot:P36949" /translation="MKKAVSVILTLSLFLLTACSLEPPQWAKPSNSGNKKEFTIGLSV STLNNPFFVSLKKGIEKEAKKRGMKVIIVDAQNDSSKQTSDVEDLIQQGVDALLINPT DSSAISTAVESANAVGVPVVTIDRSAEQGKVETLVASDNVKGGEMAAAFIADKLGKGA KVAELEGVPGASATRERGSGFHNIADQKLQVVTKQSADFDRTKGLTVMENLLQGHPDI QAVFAHNDEMALGALEAINSSGKDILVIGFDGNKDALASIKDRKLSATVAQQPELIGK LATEAADDILHGKKVQKTISAPLKLETQK*" /label="rbsB CDS" gene 3169483..3170400 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /label="rbsB gene" promotor_-35 3170409..3170415 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3170430..3170448 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3170432 /Source="Nicolas_upshifts" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="upshifts" CDS 3170482..3171018 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall binding enzyme" /protein_id="NP_391478.1" /db_xref="EnsemblGenomes-Gn:BSU35970" /db_xref="EnsemblGenomes-Tr:CAB15614" /db_xref="GOA:P96729" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR036028" /db_xref="SubtiList:BG12530" /db_xref="UniProtKB/Swiss-Prot:P96729" /translation="MNKPTKLFSTLALAAGMTAAAAGGAGTIHAQQPETTVSIDDLYS YPIDSYLVSAEALNVRTKPSASSQKADTLHLGDSLKLISFSNADWAKVKYKNGKTGFV STHYIVKAATTVKTKTKTKVYTSADGKSIKTLPADTSVSFLGWSKTNKGGFDFDWVFV DYGGTTGYMKTKDLHMTK*" /label="ywsB CDS" gene 3170482..3171018 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /label="ywsB gene" downshifts 3171001 /Source="Nicolas_upshifts" /id="D1857" /incds=0 /nref=187 /ntot=255 /MaxReadThrough="5.87246" /MaxDrop="7.38203" /score="26.4284327" /energy="-19" /TU="U2817" /idTUdmin="U2814" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature 3171046..3171156 /Source="Nicolas_S_feature" /locus_tag="new_3707708_3707818" /HighExp="Etha, M9-stat, Sw, M40t90, G150, B60, T0.30H, M0t90, T1.30H, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1383" promotor_-35 3171125..3171131 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3171146..3171157 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3171158 /Source="Nicolas_upshifts" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3171174..3171470 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11782522" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391479.1" /db_xref="EnsemblGenomes-Gn:BSU35980" /db_xref="EnsemblGenomes-Tr:CAB15615" /db_xref="InterPro:IPR024997" /db_xref="SubtiList:BG12529" /db_xref="UniProtKB/Swiss-Prot:P96728" /translation="MDQFEAAYESYKARQTTADQENVPSGKEEIIAVRRNEEDNIIAV KTNTGRELDYPTALSEAKSGKLAHVDVFHKYGRDILRSEPDGIKENNLSELPDF*" /label="ywsA CDS" gene 3171174..3171470 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /label="ywsA gene" S_feature 3171471..3172123 /Source="Nicolas_S_feature" /locus_tag="new_3708133_3708785" /HighExp="Etha, M9-stat, S5, S7, S6, Sw, S8, B60, G150, S4" /AntisenseName="ywrO" /AntisenseCor="-0.23279201478213099" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1384" CDS complement(3171510..3172037) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11782522, 14697229, 17768344; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase (unknown substrate)" /protein_id="NP_391480.1" /db_xref="EnsemblGenomes-Gn:BSU35990" /db_xref="EnsemblGenomes-Tr:CAB15616" /db_xref="GOA:P80871" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12528" /db_xref="UniProtKB/Swiss-Prot:P80871" /translation="MKILVLAVHPHMETSVVNKAWAEELSKHDNITVRDLYKEYPDEA IDVAKEQQLCEEYDRIVFQFPLYWYSSPPLLKKWQDLVLTYGWAFGSEGNALHGKELM LAVSTGSEAEKYQAGGANHYSISELLKPFQATSNLIGMKYLPPYVFYGVNYAAAEDIS HSAKRLAEYIQQPFV*" /label="ywrO CDS" gene complement(3171510..3172037) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /label="ywrO gene" downshifts complement(3171520) /Source="Nicolas_upshifts" /id="D1858" /incds=0 /nref=48 /ntot=208 /MaxReadThrough="3.48831" /MaxDrop="4.56453" /score="1.41593376" /energy="-17.4" /TU="U2819" /idTUdmin="U2821" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3172057..3172076) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3172070) /Source="Nicolas_upshifts" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="upshifts" downshifts 3172081 /Source="Nicolas_upshifts" /id="D1859" /incds=0 /nref=26 /ntot=56 /MaxReadThrough="0.805200000000001" /MaxDrop="4.7199" /score="10.409416" /energy="-6.8" /TU="NA" /idTUdmin="U2817" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3172090..3172097) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3172136) /Source="Nicolas_upshifts" /id="D1860" /incds=0 /nref=20 /ntot=149 /MaxReadThrough="4.85403" /MaxDrop="6.46739" /score="-8.02974492" /energy="-5" /TU="U2821" /idTUdmin="U2821" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3172137..3172904) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /EC_number="4.1.1.5" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7685336, 10972805, 12363365, 17183216, 21531833, 26454865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7685336, 10972805, 12363365, 17183216, 21531833, 26454865; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate decarboxylase" /protein_id="NP_391481.1" /db_xref="EnsemblGenomes-Gn:BSU36000" /db_xref="EnsemblGenomes-Tr:CAB15617" /db_xref="GOA:Q04777" /db_xref="InterPro:IPR005128" /db_xref="SubtiList:BG10472" /db_xref="UniProtKB/Swiss-Prot:Q04777" /translation="MKRESNIQVLSRGQKDQPVSQIYQVSTMTSLLDGVYDGDFELSE IPKYGDFGIGTFNKLDGELIGFDGEFYRLRSDGTATPVQNGDRSPFCSFTFFTPDMTH KIDAKMTREDFEKEINSMLPSRNLFYAIRIDGLFKKVQTRTVELQEKPYVPMVEAVKT QPIFNFDNVRGTIVGFLTPAYANGIAVSGYHLHFIDEGRNSGGHVFDYVLEDCTVTIS QKMNMNLRLPNTADFFNANLDNPDFAKDIETTEGSPE*" /label="alsD CDS" gene complement(3172137..3172904) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /label="alsD gene" CDS complement(3172966..3174678) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /EC_number="2.2.1.6" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972805, 12363365, 17183216, 7685336, 25393087, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972805, 12363365, 17183216, 7685336, 25393087, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate synthase" /protein_id="NP_391482.2" /db_xref="EnsemblGenomes-Gn:BSU36010" /db_xref="EnsemblGenomes-Tr:CAB15618" /db_xref="GOA:Q04789" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012782" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10471" /db_xref="UniProtKB/Swiss-Prot:Q04789" /translation="MTKATKEQKSLVKNRGAELVVDCLVEQGVTHVFGIPGAKIDAVF DALQDKGPEIIVARHEQNAAFMAQAVGRLTGKPGVVLVTSGPGASNLATGLLTANTEG DPVVALAGNVIRADRLKRTHQSLDNAALFQPITKYSVEVQDVKNIPEAVTNAFRIASA GQAGAAFVSFPQDVVNEVTNTKNVRAVAAPKLGPAADDAISAAIAKIQTAKLPVVLVG MKGGRPEAIKAVRKLLKKVQLPFVETYQAAGTLSRDLEDQYFGRIGLFRNQPGDLLLE QADVVLTIGYDPIEYDPKFWNINGDRTIIHLDEIIADIDHAYQPDLELIGDIPSTINH IEHDAVKVEFAEREQKILSDLKQYMHEGEQVPADWKSDRAHPLEIVKELRNAVDDHVT VTCDIGSHAIWMSRYFRSYEPLTLMISNGMQTLGVALPWAIGASLVKPGEKVVSVSGD GGFLFSAMELETAVRLKAPIVHIVWNDSTYDMVAFQQLKKYNRTSAVDFGNIDIVKYA ESFGATGLRVESPDQLADVLRQGMNAEGPVIIDVPVDYSDNINLASDKLPKEFGELMK TKAL*" /label="alsS CDS" gene complement(3172966..3174678) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /label="alsS gene" promotor_-35 3173577..3173586 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3173600..3173619 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3173600 /Source="Nicolas_upshifts" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3174732..3174751) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3174737) /Source="Nicolas_upshifts" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3174757..3174764 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3174766..3174770) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3174778..3174797 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3174788 /Source="Nicolas_upshifts" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="upshifts" CDS 3174836..3175744 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling alsSD, ictEP expression (LysR family)" /protein_id="NP_391483.1" /db_xref="EnsemblGenomes-Gn:BSU36020" /db_xref="EnsemblGenomes-Tr:CAB15619" /db_xref="GOA:Q04778" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10470" /db_xref="UniProtKB/Swiss-Prot:Q04778" /translation="MELRHLQYFIAVAEELHFGKAARRLNMTQPPLSQQIKQLEEEVG VTLLKRTKRFVELTAAGEIFLNHCRMALMQIGQGIELAQRTARGEQGLLVIGFVGSAT YEFLPPIVREYRKKFPSVKIELREISSSRQQEELLKGNIDIGILHPPLQHTALHIETA QSSPCVLALPKQHPLTSKESITIEDLRDEPIITVAKEAWPTLYMDFIQFCEQAGFRPN IVQEATEYQMVIGLVSAGIGMTFVPSSAKKLFNLDVTYRKMDQIQLNAEWVIAYRKDN HNPLIKHFIHISNCQQTRTKESDAGT*" /label="alsR CDS" gene 3174836..3175744 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /label="alsR gene" promotor_-35 3175812..3175820 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3175822..3175954 /Source="Nicolas_S_feature" /locus_tag="new_3712484_3712616" /HighExp="BT, S8, B36, S7, G/S, S6, Pyr, B60, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.14666000000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.896, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1385" upshifts 3175822 /Source="Nicolas_upshifts" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3175834..3175853 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3175955..3177283 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/H+ antiporter" /protein_id="NP_391484.1" /db_xref="EnsemblGenomes-Gn:BSU36030" /db_xref="EnsemblGenomes-Tr:CAB15620" /db_xref="GOA:O05224" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12527" /db_xref="UniProtKB/Swiss-Prot:O05224" /translation="MLAFFVTMIFIFWRPKGLNEAIPATFGALMVLLCGSVSLADLGE IGTKVTGASVTILATMIMAIALESFGFFYWVAAKLLQQSKGSGIKLFWLTNLLCFLMT IFLNNDGSILITTPILLLVLKYLGLKKHQKAPYLLSGVLIATASSAPIGVSNIVNLIS LKIIGMDLYLHTAMMFVPSMMGLIFMTCLLFMFFYKRLPKSLPDIPGHFQSLRHRRYH PLHSPSAPLPERNQTKIMLFVLAFVFLVRMSLFAASYTGISVPLVAVIGSFILLSWRW IYFKTSPRDLLYKSPWHIFIFAFTMYVLIYGLHNIGFTELLVSYFEPVVSGSLAHATF ASGISTSVFSNLFNNHPALMISTFTLTEMTLNPSTTKIIYLANIIGSDIGSLLLPMGT LATLIWMHILKQHDESISWGEYIKTTIIIIPLTVLFTLTCLYFWISWLFL*" /label="ywrK CDS" gene 3175955..3177283 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /label="ywrK gene" downshifts 3177274 /Source="Nicolas_upshifts" /id="D1861" /incds=0 /nref=16 /ntot=32 /MaxReadThrough="1.63489" /MaxDrop="6.12455" /score="-6.14091334" /energy="-11.9" /TU="NA" /idTUdmin="U2823" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3177340..3178017) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14762006, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391485.1" /db_xref="EnsemblGenomes-Gn:BSU36040" /db_xref="EnsemblGenomes-Tr:CAB15621" /db_xref="InterPro:IPR020139" /db_xref="InterPro:IPR020173" /db_xref="SubtiList:BG12526" /db_xref="UniProtKB/Swiss-Prot:O05223" /translation="MKGLNQFLNTDVEVVISGDTRFVGTLIDIGQDIFVIFDGCNYLY IPLLHLHQINKAKIVTSTEKPFLINPEDPMIEAETQAFSYRNTLNKVKGQFIEVYVTG GRSIHGYVTNVLNDYIVFFSPVFKILFISMHHLKWFTPYSTEQTPYTLDNSQLPVVPS KVPLVRNFEEQIKKNIGELVIFDMGEVPEKVGLLKGVSNNIIELINASGEPVIWKLNH LKTMHLP*" /label="ywrJ CDS" gene complement(3177340..3178017) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /label="ywrJ gene" downshifts complement(3177350) /Source="Nicolas_upshifts" /id="D1862" /incds=0 /nref=14 /ntot=28 /MaxReadThrough="1.74629" /MaxDrop="5.1172" /score="-4.02447737" /energy="-9.5" /TU="NA" /idTUdmin="U2824" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3178077..3179219) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8755863, 10559171, 11737650, 14762006, 19933362, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755863, 10559171, 11737650, 14762006, 19933362, 27185916; Product type s : structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_391486.1" /db_xref="EnsemblGenomes-Gn:BSU36050" /db_xref="EnsemblGenomes-Tr:CAB15622" /db_xref="GOA:P07789" /db_xref="SubtiList:BG10491" /db_xref="UniProtKB/Swiss-Prot:P07789" /translation="MSKRRMKYHSNNEISYYNFLHSMKDKIVTVYRGGPESKKGKLTA VKSDYIALQAEKKIIYYQLEHVKSITEDTNNSTTTIETEEMLDADDFHSLIGHLINQS VQFNQGGPESKKGRLVWLGDDYAALNTNEDGVVYFNIHHIKSISKHEPDLKIEEQTPV GVLEADDLSEVFKSLTHKWVSINRGGPEAIEGILVDNADGHYTIVKNQEVLRIYPFHI KSISLGPKGSYKKEDQKNEQNQEDNNDKDSNSFISSKSYSSSKSSKRSLKSSDDQSSK SGRSSRSKSSSKSSKRSLKSSDYQSSKSGRSSRSKSSSKSSKRSLKSSDYQSSKSSKR SPRSSDYQSSRSPGYSSSIKSSGKQKEDYSYETIVRTIDYHWKRKF*" /label="cotB CDS" gene complement(3178077..3179219) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /label="cotB gene" promotor_-10 complement(3179256..3179275) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3179264) /Source="Nicolas_upshifts" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3179266..3179346) /Source="Nicolas_S_feature" /locus_tag="new_3715928_3716008_c" /HighExp="S6, S7, S8, S5, BT, B36, S4, G/S, Pyr, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1386" promotor_-35 complement(3179289..3179297) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3179347..3180435) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762006, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762006, 25115591, 27185916; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein kinase" /protein_id="NP_391487.1" /db_xref="EnsemblGenomes-Gn:BSU36060" /db_xref="EnsemblGenomes-Tr:CAB15623" /db_xref="GOA:Q45535" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG11791" /db_xref="UniProtKB/Swiss-Prot:Q45535" /translation="MKNQSNLPLYQLFVHPKDLRELKKDIWDDDPVPAVMKVNQKRLD IDIAYRGSHIRDFKKKSYHISFYQPKTFRGAREIHLNAEYKDPSLMRNKLSLDFFSEL GTLSPKAEFAFVKMNGKNEGVYLELESVDEYYLAKRKLADGAIFYAVDDDANFSLMSD LERETKTSLELGYEKKTGTEEDDFYLQDMIFKINTVPKAQFKSEVTKHVDVDKYLRWL AGIVFTSNYDGFVHNYALYRSGETGLFEVIPWDYDATWGRDIHGERMAADYVRIQGFN TLTARILDESEFRKSYKRLLEKTLQSLFTIEYMEPKIMAMYERIRPFVLMDPYKKNDI ERFDREPDVICEYIKNRSQYLKDHLSIL*" /label="cotH CDS" gene complement(3179347..3180435) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /label="cotH gene" S_feature complement(3180436..3180549) /Source="Nicolas_S_feature" /locus_tag="new_3717098_3717211_c" /HighExp="S6, S8, S7, S5, BT, B36, Pyr, G/S, S4, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1387" promotor_-35 3180491..3180500 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3180513..3180532 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3180526 /Source="Nicolas_upshifts" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3180549) /Source="Nicolas_upshifts" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3180553..3180567) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3180576..3180580) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3180576..3181163 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14762006, 15621419, 22720735, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14762006, 15621419, 22720735, 25115591, 27185916; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore morphogenetic protein" /protein_id="NP_391488.1" /db_xref="EnsemblGenomes-Gn:BSU36070" /db_xref="EnsemblGenomes-Tr:CAB15624" /db_xref="GOA:P39801" /db_xref="SubtiList:BG11017" /db_xref="UniProtKB/Swiss-Prot:P39801" /translation="MGHYSHSDIEEAVKSAKKEGLKDYLYQEPHGKKRSHKKSHRTHK KSRSHKKSYCSHKKSRSHKKSFCSHKKSRSHKKSYCSHKKSRSHKKSYRSHKKSRSYK KSYRSYKKSRSYKKSCRSYKKSRSYKKSYCSHKKKSRSYKKSCRTHKKSYRSHKKYYK KPHHHCDDYKRHDDYDSKKEYWKDGNCWVVKKKYK*" /label="cotG CDS" gene 3180576..3181163 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /label="cotG gene" CDS 3180664..3181143 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /function="14.1: Surface structures" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="doubtful CDS (putative in frame frameshift)" /protein_id="YP_009514005.1" /translation="MEKNAVIKSRTALTKNLAAIKNHTALTKNLAVTKNHSVLTKNLA ATKNHTALTRNLAATKNRTVLTKNLAAIKNLTVLTKNLVAIKNLAVLTKNLAATKSLT VLTRKNLAAIRSHAAHTKNLIVPIRNTTKNRTTTATTTKDTMIMTAKKNTGKTAIAG* " /label="doubtful CDS (putative in frame frameshift)" gene 3180664..3181143 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /label="gene" S_feature complement(3181047..3181244) /Source="Nicolas_S_feature" /locus_tag="new_3717709_3717906_c" /HighExp="S5, S6, S4, B60, S3, nit, G/S, SMMPr, S8, ferm" /AntisenseName="cotG" /AntisenseCor="0.60092819988141299" /AntisenseRegPval="-27.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1388" downshifts 3181080 /Source="Nicolas_upshifts" /id="D1863" /incds=1 /nref=1 /ntot=54 /MaxReadThrough="7.80801" /MaxDrop="2.7794" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(3181090) /Source="Nicolas_upshifts" /id="D1864" /incds=1 /nref=3 /ntot=23 /MaxReadThrough="4.99409" /MaxDrop="6.67733" /score="-1.37249416" /energy="-5.2" /TU="U2827" /idTUdmin="U2824" /TUdmin="-3740" /isTUend="FALSE" /label="downshifts" downshifts 3181149 /Source="Nicolas_upshifts" /id="D1865" /incds=0 /nref=41 /ntot=80 /MaxReadThrough="4.68169" /MaxDrop="5.35584" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts 3181228 /Source="Nicolas_upshifts" /id="D1866" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="2.30708" /MaxDrop="3.92552" /score="17.1895651" /energy="-10.7" /TU="NA" /idTUdmin="U2825" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3181243..3181262) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3181249) /Source="Nicolas_upshifts" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3181271..3181278 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3181275..3181284) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3181293..3181312 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3181299 /Source="Nicolas_upshifts" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="upshifts" CDS 3181337..3181954 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /EC_number="1.14.13.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-binding monooxygenase" /protein_id="NP_391489.1" /db_xref="EnsemblGenomes-Gn:BSU36080" /db_xref="EnsemblGenomes-Tr:CAB15625" /db_xref="GOA:O05220" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12525" /db_xref="UniProtKB/Swiss-Prot:O05220" /translation="MYIFQADQLSAKDTYKLLSGTVIPRPIAFVTTLSSGGAVNAAPF SFYNVVSSDPPLLSISVNRTEGRQKDTARNAVENGEFVVHVSDEAIIEDINETAASLR PDESELTRTSLHPVESKAVSVPGIKEARVRFECKLERHITFDNDQGITTADLLIGRVV CFHLDEKVYDAEKGYILTDELKPASRLAGNHYAKLGEEFTLIRPS*" /label="ywrF CDS" gene 3181337..3181954 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /label="ywrF gene" S_feature 3181955..3182055 /Source="Nicolas_S_feature" /locus_tag="new_3718617_3718717" /HighExp="Etha, dia5, Diami, dia15, Lbtran, LBGtran, LPhT, M40t45, M40t90, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1389" downshifts 3182012 /Source="Nicolas_upshifts" /id="D1867" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="4.52989" /MaxDrop="4.48979" /score="-1.9002322" /energy="-14.9" /TU="U2828" /idTUdmin="U2828" /TUdmin="-454" /isTUend="FALSE" /label="downshifts" promotor_-35 3182081..3182090 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3182102..3182117 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3182103 /Source="Nicolas_upshifts" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3182132..3182467 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391490.1" /db_xref="EnsemblGenomes-Gn:BSU36090" /db_xref="EnsemblGenomes-Tr:CAB15626" /db_xref="GOA:O05219" /db_xref="InterPro:IPR025441" /db_xref="SubtiList:BG12524" /db_xref="UniProtKB/Swiss-Prot:O05219" /translation="MTNFWILMLIAITISLASQFFIKKKYGIDKSGWRYKHVSNTHKW IEITLLILFVFSLSFFPVEYLLLLFFIVIDSIRIFMEWHYRPEDKQYMYHIVEVSLMF MLLIYVCTL*" /label="ywrE CDS" gene 3182132..3182467 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /label="ywrE gene" promotor_-10 complement(3182423..3182441) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3182432) /Source="Nicolas_upshifts" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3182456..3182461) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3182466 /Source="Nicolas_upshifts" /id="D1868" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="5.64855" /MaxDrop="3.64569" /score="-1.9002322" /energy="-14.9" /TU="U2829" /idTUdmin="U2828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3182472..3184049) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /EC_number="3.5.1.126" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12823818, 14762019, 19935659, 27303801, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxamate amidohydrolase" /protein_id="NP_391491.1" /db_xref="EnsemblGenomes-Gn:BSU36100" /db_xref="EnsemblGenomes-Tr:CAB15627" /db_xref="GOA:O05218" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="SubtiList:BG12523" /db_xref="UniProtKB/Swiss-Prot:O05218" /translation="MNKSVIGTKQMVVSPHYLASQAGNRILDKGGNAFDAAVAVSACL AVVYPHMTGLGGDSFWLTFHQETKAVKVYNGSGRSGKNVTRDVYKGKSAIPLRGIDSA ITVPGMVDSWDAVLKEYGRLSLADVLEPARDYAQNGFPVSADQCRHTEKNIELLASTP YTADIFTRRGKAPVPGERFVQKELADSLNLIAEKGRSAFYEGDLAQRIVSHLQNNGSY MTIDDFKAHRGEWAAPVSSDYRGYSVYQAPPNSQGFTGLLTLNILENYDFTQIEHGSF EYYHVLVEALKKSFLDRDAVLTDPAFADIPLERLLDKRYAKQLAEEIGYLAIPAESRP VGSDTAYAAVIDADGNAVSFIQSLYFEFGSAVTAGDTGILLQNRGSFFSLDENHVNTL EPRKRTFHTLMPAMVCKGGKPKILYGTQGGEGQPQTQTAIITRMLDYGMHPQQAISEP RWVWGRTWGEEYEGLRVEGRFTDKTIQKLKDSGHLVEVVGDYDPLMGQAAAIKVDEEG FLQGGADPRGDGAAVGI*" /label="hpxW CDS" gene complement(3182472..3184049) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /label="hpxW gene" S_feature 3182511..3184222 /Source="Nicolas_S_feature" /locus_tag="new_3719173_3720884" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T-0.40H, T0.0H, Salt" /AntisenseName="ywrD" /AntisenseCor="0.153519829066777" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1390" promotor_-35 3184200..3184207 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3184218..3184237 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3184224 /Source="Nicolas_upshifts" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3184263..3184739 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23989926; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional negative regulator of chromate transport (Lrp/AsnC family)" /protein_id="NP_391492.1" /db_xref="EnsemblGenomes-Gn:BSU36110" /db_xref="EnsemblGenomes-Tr:CAB15628" /db_xref="GOA:O05217" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12522" /db_xref="UniProtKB/Swiss-Prot:O05217" /translation="MSHEYQIPNLVLDETDKQILTILHEEGRISYTDLGKRVDLSRVA VQARINQLIEAGVIEKFTAVINPAKIGIHVSVFFNVEVEPQFLEEVALKLEEEPAVTS LYHMTGPSKLHMHGIFTNDQEMEEFLTKRLYPLRGVVSVDCQMLIKRYKSRMGMKL*" /label="chrS CDS" gene 3184263..3184739 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /label="chrS gene" CDS 3184753..3185346 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit N" /protein_id="NP_391493.1" /db_xref="EnsemblGenomes-Gn:BSU36120" /db_xref="EnsemblGenomes-Tr:CAB15629" /db_xref="GOA:O05216" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12521" /db_xref="UniProtKB/Swiss-Prot:O05216" /translation="MKNHPYRDMTAAMVRTGILGFGGGPSVIPLIRHEAVNKYKWIDD DEFGEILAIANALPGPIATKMAAYLGFKLKGTLGAIVAILAHILPTCLAMVGLFAAVN VLSHSAIVAGMIGAVTPVIAVMLGIMAYEFGQKALKGFGWVTGILFFIIAFIGLQTLQ INPGLVIIIFLAYGAFHFKLKDKITNKHSKDKGMSAS*" /label="chrB CDS" gene 3184753..3185346 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /label="chrB gene" CDS 3185343..3185879 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit C" /protein_id="NP_391494.1" /db_xref="EnsemblGenomes-Gn:BSU36130" /db_xref="EnsemblGenomes-Tr:CAB15630" /db_xref="GOA:O05215" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12520" /db_xref="UniProtKB/Swiss-Prot:O05215" /translation="MISIYLFMAFFIANLLGYGGGPASIPLMFEEVVNRYSWLSNDQF SNMLALANALPGPIATKIAAYVGYSAGGWPGFLIALIATVVPSALALIVLLRIIQRFR QSPVIKGMTLSVQPVIAVMMLILTWQIGADGIKAIGWVQSIVITGISLLAMTKFKMHP AFLIIAAFLYGGLVIPYL*" /label="chrA CDS" gene 3185343..3185879 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /label="chrA gene" downshifts 3185860 /Source="Nicolas_upshifts" /id="D1869" /incds=0 /nref=4 /ntot=90 /MaxReadThrough="0.0513700000000004" /MaxDrop="3.46649" /score="29.5508265" /energy="-8.6" /TU="NA" /idTUdmin="U2829" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(3185906..3186127) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391495.1" /db_xref="EnsemblGenomes-Gn:BSU36140" /db_xref="EnsemblGenomes-Tr:CAB15631" /db_xref="SubtiList:BG12519" /db_xref="UniProtKB/Swiss-Prot:P96727" /translation="MKFLLSVIAGLLILALYLFWKVQPPVWIQVETNSSQLKQSVRMA GTTLQVKHMIKSDAGEETAVISNGISGLK*" /label="ywqO CDS" gene complement(3185906..3186127) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /label="ywqO gene" upshifts 3186074 /Source="Nicolas_upshifts" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3186081..3186082 /Source="Nicolas_upshift_promotors" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3186124..3186669) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391496.1" /db_xref="EnsemblGenomes-Gn:BSU36150" /db_xref="EnsemblGenomes-Tr:CAB15632" /db_xref="GOA:P96726" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLI" /db_xref="SubtiList:BG12518" /db_xref="UniProtKB/Swiss-Prot:P96726" /translation="MKIAVINGGTRSGGNTDVLAEKAVQGFDAEHIYLQKYPIQPIED LRHAQGGFRPVQDDYDSIIERILQCHILIFATPIYWFGMSGTLKLFIDRWSQTLRDPR FPDFKQQMSVKQAYVIAVGGDNPKIKGLPLIQQFEHIFHFMGMSFKGYVLGEGNRPGD ILRDHQALSAASRLLKRSDAI*" /label="ywqN CDS" gene complement(3186124..3186669) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /label="ywqN gene" promotor_-35 3186686..3186693 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3186708..3186727 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3186712 /Source="Nicolas_upshifts" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="upshifts" CDS 3186792..3187673 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391497.1" /db_xref="EnsemblGenomes-Gn:BSU36160" /db_xref="EnsemblGenomes-Tr:CAB15633" /db_xref="GOA:P96725" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12517" /db_xref="UniProtKB/Swiss-Prot:P96725" /translation="MELKQLITFITAAEHVNFTLTAKMLNYAQSSVTSQIKSLEEEIG TPLFERLGKRLILTEAGKTFKSYAQKIIALTEEAKMATNQVRETTGTLKIGATESQCT YRLPPIIKEFKQAFPQVKLIFKPYISNEQAKEQLLQGQLDITFILDVNRMEDALHVES LIQDEIKMVAANDHPFPADLPVTLKDLQNETLLLTEDGCSYRTLFENNLHDSGIYPNK LEFVSIEAIKQCVMAGLGIGILPEMTVKDDIAAGRMKELNWQSDCPVFTQLAWHKDKW MSAPLKAFIDLTRKTFK*" /label="ywqM CDS" gene 3186792..3187673 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /label="ywqM gene" CDS complement(3187758..3188474) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /EC_number="3.1.21.7" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1692969, 22056936, 27530626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1692969, 22056936, 27530626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease V" /protein_id="NP_391498.2" /db_xref="EnsemblGenomes-Gn:BSU36170" /db_xref="EnsemblGenomes-Tr:CAB15634" /db_xref="GOA:P96724" /db_xref="InterPro:IPR007581" /db_xref="PDB:3GA2" /db_xref="SubtiList:BG12516" /db_xref="UniProtKB/Swiss-Prot:P96724" /translation="MKVFDVHKFDMKKEQDFLQVQFNLKNRINLSPTIHPDSINTCAG VDLAYWEQDGEPYGVCCIIVIDADTKEVIEKVHSMGRISVPYVSGFLAFRELPLIIEA AKKLETEPDVFLFDGNGYLHYNHMGVATHAAFFLGKPTIGIAKTYLKIKGCDFVTPEI EVGAYTDIIIDGEVYGRALRTRRDVKPIFLSCGNYIDLDSSYQITMSLINQESRLPIP VRLADLETHVLRTFYQKNHV*" /label="nfi CDS" gene complement(3187758..3188474) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /label="nfi gene" downshifts complement(3187778) /Source="Nicolas_upshifts" /id="D1870" /incds=0 /nref=44 /ntot=216 /MaxReadThrough="1.91774" /MaxDrop="3.62442" /score="12.1019223" /energy="-7.4" /TU="NA" /idTUdmin="U2834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3188484..3188948) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease antitoxin" /protein_id="NP_391499.1" /db_xref="EnsemblGenomes-Gn:BSU36180" /db_xref="EnsemblGenomes-Tr:CAB15635" /db_xref="InterPro:IPR011652" /db_xref="SubtiList:BG12515" /db_xref="UniProtKB/Swiss-Prot:P96723" /translation="MENEYDMKSIKEKGVDFEDLWFSSVSDEILDNPEDENGQPFTGL AYELYPNGQIIYFTKYKNGLAHGLTCEFYENGNKKSEKEYRYGQLHGISIIWFENGRK KSEQQYEHSILISEKNWDEEGNLLNKYEIDTDSPHFEILESRRETHINLGRE*" /label="rttO CDS" gene complement(3188484..3188948) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /label="rttO gene" CDS complement(3188938..3190746) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /EC_number="3.1.-.-" /function="15.8: Toxin production and resistance" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease toxin" /protein_id="NP_391500.1" /db_xref="EnsemblGenomes-Gn:BSU36190" /db_xref="EnsemblGenomes-Tr:CAB15636" /db_xref="GOA:P96722" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR025968" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG12514" /db_xref="UniProtKB/Swiss-Prot:P96722" /translation="MSKVFESKSLIEEAKSRKKQYETLEEQLNTLKKAFQGVADLGDN FKGNGADNIKDFFQGQAEIVDSWLTLVSAQIAFLNGISGDIKDQELNDSYVETSFLDH ELPNGDLKASEIVSAHKEEIDSILSGISDIIDLDMYTLDDYADKMGDAQKIRRDTITA VDKLDESLTTEYQNLESLDNAVLTKYSVLMQATSNGKSASPMYYDKKAFHSNEVYKSV IEVENQGTTYIDAKTQQAEARRLQEKAEEEANKPWYEKTWDGVCNFTGEVTGYYDYKR ATEGVDPVTGEKLSTAERVTAGAMAAAGFIPVVGWAGRAFKGGKAIYKTGKAAIAAEH ALDAYKTGKSLDILKMTEMGAYGLVASNGFSEAVTGRDMFGNKVSEEKRKQGALEAIT IIGGAGLAHYFDRLYQKNAPYVNKVSNESLISNIAKTTEEKQTRLQYLRNKHGVLSKE DLHHRINLRAEVLNELSRIKSSGLTKKQRGPAVAGVLDKKTGNYYFGINNIDGKPPKV LHPLIHDRIVNMPTELKEGYIKTSGAGSHAEVNALNEALLQRPDADLKDLMVYVVSAR KINKKMPEGVPMPRCPHCEYITQNTNYIPEALKYGK*" /label="rttN CDS" gene complement(3188938..3190746) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /label="rttN gene" CDS complement(3190765..3191025) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391501.1" /db_xref="EnsemblGenomes-Gn:BSU36200" /db_xref="EnsemblGenomes-Tr:CAB15637" /db_xref="InterPro:IPR020299" /db_xref="SubtiList:BG12513" /db_xref="UniProtKB/Swiss-Prot:P96721" /translation="MSEIKLKYDTVIKTLDSVKDALADVSIGAAGSNGKNSLDYTKKY HEREENIKTMLGDYKKAVQKNIEDTKDNVDSLKEQDEAIAVK*" /label="ywqI CDS" gene complement(3190765..3191025) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /label="ywqI gene" CDS complement(3191035..3191457) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15101989" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391502.1" /db_xref="EnsemblGenomes-Gn:BSU36210" /db_xref="EnsemblGenomes-Tr:CAB15638" /db_xref="InterPro:IPR020326" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG12512" /db_xref="UniProtKB/Swiss-Prot:P96720" /translation="MGYESMLADIKSSLNGKISDVEDKIEKLKKAKKDIDTLQEEAIT EIKEIVKPELGKHWTGTKADDFDKGREEAKSEASKIVNDKYNEYMASINGKIFDLEWD KAKYASELFIANGAADLLKKGEEFAEEVGNTISKLKWW*" /label="ywqH CDS" gene complement(3191035..3191457) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /label="ywqH gene" S_feature complement(3191458..3191540) /Source="Nicolas_S_feature" /locus_tag="new_3728120_3728202_c" /HighExp="T2.30H, T4.0H, T5.0H, T3.0H, T3.30H, T1.30H, T2.0H, S4, T-0.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1391" promotor_-10 complement(3191532..3191551) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3191540) /Source="Nicolas_upshifts" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3191564..3191571) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3191674..3191799) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514006.1" /translation="MTKSDMADQMKNINMNNKLSAERGRSTTSASFKCLYNYDIR*" /label="hypothetical protein CDS" gene complement(3191674..3191799) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /label="gene" S_feature complement(3191717..3191848) /Source="Nicolas_S_feature" /locus_tag="new_3728379_3728510_c" /HighExp="HiOs, BI, M9-tran, T-2.40H, MG 150, Sw, M9-exp, S1, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19133600000000001" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1392" downshifts complement(3191760) /Source="Nicolas_upshifts" /id="D1871" /incds=0 /nref=29 /ntot=208 /MaxReadThrough="3.03928" /MaxDrop="3.47153" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2835" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3191849..3192634) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391503.1" /db_xref="EnsemblGenomes-Gn:BSU36220" /db_xref="EnsemblGenomes-Tr:CAB15639" /db_xref="InterPro:IPR015315" /db_xref="InterPro:IPR035948" /db_xref="PDB:1PV5" /db_xref="SubtiList:BG12511" /db_xref="UniProtKB/Swiss-Prot:P96719" /translation="MNHLPEKMRPYRDLLEKSAKEYVKLNVRKGKTGRYDSKIAGDPY FPKHETYPTDENGQPMKLLAQINFSHIPQLDGYPSSGILQFYISVHDDVYGLNFDDRC EQKNFRVIYFENIVENDDELVSDFSFIGTGECDFPILSEAAVEPVKSSEWVLPTDFQF EQYTGMETMEFFGQFGEDEEDIYNELAENGFGHKIGGYASFTQHDPREYAYKEHTIML LQIDSDDDIDSMWGDVGIANFFITPEDLRKKDFSNVLYNWDCS*" /label="ywqG CDS" gene complement(3191849..3192634) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /label="ywqG gene" S_feature complement(3192635..3192750) /Source="Nicolas_S_feature" /locus_tag="new_3729297_3729412_c" /HighExp="HiOs, T-1.40H, T-2.40H, T-3.40H, M9-tran, MG 150, SMM, GM 150, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1393" promotor_-10 complement(3192743..3192762) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3192750) /Source="Nicolas_upshifts" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3192776..3192783) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3192826..3194148) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 15866923, 16415592" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 15866923, 16415592; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose dehydrogenase" /protein_id="NP_391504.1" /db_xref="EnsemblGenomes-Gn:BSU36230" /db_xref="EnsemblGenomes-Tr:CAB15640" /db_xref="GOA:P96718" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12510" /db_xref="UniProtKB/Swiss-Prot:P96718" /translation="MNITVIGTGYVGLVTGVSLSEIGHHVTCIDIDAHKIDEMRKGIS PIFEPGLEELMRKNTADGRLNFETSYEKGLAQADIIFIAVGTPQKSDGHANLEQITDA AKRIAKHVKRDTVVVTKSTVPVGTNDLINGLITEHLAEPVSISVASNPEFLREGSAIY DTFHGDRIVIGTADEKTANTLEELFRPFQIPIYQTDIRSAEMIKYASNAFLATKISFI NEISNICEKVGADIEAVAYGMGQDKRIGSQFLKAGIGYGGSCFPKDTNALVQIAGNVE HDFELLKSVIKVNNNQQAMLVDKALNRLGGVTGKTIALLGLSFKPNTDDMREAPSIVI ADRLAALDARIRAYDPIAVSHAKHVLPQAVEYKETIEEAVKGSDAVMILTDWADIKQF PLAAYQDLMETPLIFDGRNCYTLDEALAAGVEYYSVGRKAVVPSGAIQ*" /label="uglF CDS" gene complement(3192826..3194148) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /label="uglF gene" downshifts complement(3192838) /Source="Nicolas_upshifts" /id="D1872" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.29767" /MaxDrop="6.20721" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2836" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3194182) /Source="Nicolas_upshifts" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3194184..3194309) /Source="Nicolas_S_feature" /locus_tag="new_3730846_3730971_c" /HighExp="dia15, H2O2, Diami, dia5, LBGstat, Paraq, LBGexp, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13453899999999999" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1394" promotor_-10 complement(3194184..3194202) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3194218..3194223) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3194289..3194308) /Source="Nicolas_upshift_promotors" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3194309) /Source="Nicolas_upshifts" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3194343..3195107) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15866923, 16415592, 16549871, 21605684, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15866923, 16415592, 16549871, 21605684, 27148221; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine-phosphatase" /protein_id="NP_391505.1" /db_xref="EnsemblGenomes-Gn:BSU36240" /db_xref="EnsemblGenomes-Tr:CAB15641" /db_xref="GOA:P96717" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR016667" /db_xref="PDB:3QY6" /db_xref="PDB:3QY7" /db_xref="SubtiList:BG12509" /db_xref="UniProtKB/Swiss-Prot:P96717" /translation="MIDIHCHILPAMDDGAGDSADSIEMARAAVRQGIRTIIATPHHN NGVYKNEPAAVREAADQLNKRLIKEDIPLHVLPGQEIRIYGEVEQDLAKRQLLSLNDT KYILIEFPFDHVPRYAEQLFYDLQLKGYIPVIAHPERNREIRENPSLLYHLVEKGAAS QITSGSLAGIFGKQLKAFSLRLVEANLIHFVASDAHNVKTRNFHTQEALYVLEKEFGS ELPYMLTENAELLLRNQTIFRQPPQPVKRRKLFGFF*" /label="ptpZ CDS" gene complement(3194343..3195107) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /label="ptpZ gene" downshifts complement(3195126) /Source="Nicolas_upshifts" /id="D1873" /incds=0 /nref=4 /ntot=152 /MaxReadThrough="3.17433" /MaxDrop="3.31415" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(3195160..3195873) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /EC_number="2.7.10.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maintenance protein tyrosine kinase involved in biofilm formation" /protein_id="NP_391506.1" /db_xref="EnsemblGenomes-Gn:BSU36250" /db_xref="EnsemblGenomes-Tr:CAB15642" /db_xref="GOA:P96716" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12508" /db_xref="UniProtKB/Swiss-Prot:P96716" /translation="MALRKNRGSRMQRNVIAMTEPKSLNSEQYRTIRTNIEFASVDRQ MKSVMITSACPGEGKSTTAANLAVVFAQQGKKVLLIDADLRKPTVHTAFFLENTVGLT SVLLKKSSMEQAVQASNEKHLDVLTSGPIPPNPAELLSSKWMKELAYEACAAYDMVIF DTPPILAVADAQILGNVADGSVLVISSGKTEKEQAAKAKEALATCKSKLLGAIMNGKK LSKHSEYGYYGTKDNFMQK*" /label="ptkA CDS" gene complement(3195160..3195873) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /label="ptkA gene" downshifts complement(3195177) /Source="Nicolas_upshifts" /id="D1874" /incds=0 /nref=10 /ntot=157 /MaxReadThrough="4.4352" /MaxDrop="4.08842" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-381" /isTUend="FALSE" /label="downshifts" CDS complement(3195863..3196609) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 23939619, 24493247, 26283769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 23939619, 24493247, 26283769; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of PtkA protein tyrosine kinase activity; modulation of biofilm formation" /protein_id="NP_391507.1" /db_xref="EnsemblGenomes-Gn:BSU36260" /db_xref="EnsemblGenomes-Tr:CAB15643" /db_xref="GOA:P96715" /db_xref="InterPro:IPR003856" /db_xref="InterPro:IPR032807" /db_xref="SubtiList:BG12507" /db_xref="UniProtKB/Swiss-Prot:P96715" /translation="MGESTSLKEILSTLTKRILLIMIVTAAATAAGGLISFFALTPIY ENSTQILVNQSKNERKEVQFNDVQTNLQLINTYNVIIKSPAILDEVIKEMGLSMTSQE LNDKITVSSEQDSQVVNISVRDENAETAAHIANTIASVFQDKITSIMNVDNVSILSKA EVSEHPSPVSPKPLLNIAIAFAAGLAGSIGLAFLLEHLDNTIKSEEQLESLLDIPVLG TVSTIANEQKTAKTLQGFQSEKTGSGHFGA*" /label="tkmA CDS" gene complement(3195863..3196609) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /label="tkmA gene" promotor_-10 complement(3196641..3196660) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3196653) /Source="Nicolas_upshifts" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3196677..3196680) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3196843..3196986) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097792.1" /db_xref="EnsemblGenomes-Gn:BSU36269" /db_xref="EnsemblGenomes-Tr:CAX52703" /db_xref="UniProtKB/Swiss-Prot:C0H3S3" /translation="MSEKKLNQEEFLKILMHAHEIGEQSSEMTTKEMLENLISHIKNG YAT*" /label="ywzD CDS" gene complement(3196843..3196986) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /label="ywzD gene" downshifts complement(3196864) /Source="Nicolas_upshifts" /id="D1875" /incds=0 /nref=221 /ntot=264 /MaxReadThrough="2.76798" /MaxDrop="8.13076" /score="15.8630799" /energy="-9.3" /TU="U2839" /idTUdmin="U2841" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3196987..3197072) /Source="Nicolas_S_feature" /locus_tag="new_3733649_3733734_c" /HighExp="S6, S8, S7, MG-0.2, S5, M9-stat, MG-0.1, MG 25, T0.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD, SigK" /TUshortPSig="0.275, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1395" misc_feature complement(3197062..3197073) /Source="Nicolas_upshift_promotors" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3197072) /Source="Nicolas_upshifts" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3197074..3197304) /Source="Nicolas_S_feature" /locus_tag="new_3733736_3733966_c" /HighExp="S6, S8, S7, S5, BT, Cold, LBGstat, LPhT, Pyr, C30" /AntisenseName="ywqB" /AntisenseCor="3.4267833233812203E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1396" promotor_-35 3197111..3197115 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3197131..3197150 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3197140 /Source="Nicolas_upshifts" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="upshifts" CDS 3197190..3198800 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative replication initiation protein" /protein_id="NP_391508.2" /db_xref="EnsemblGenomes-Gn:BSU36270" /db_xref="EnsemblGenomes-Tr:CAB15644" /db_xref="GOA:P96714" /db_xref="InterPro:IPR007527" /db_xref="SubtiList:BG12506" /db_xref="UniProtKB/Swiss-Prot:P96714" /translation="MLQNMISKDDVLASAEQLKELLPYNEENVQLIKKALILYRQDSV YRLQAVSPTEVTAYVQDVVPVRVTLNLFVIVKSGCSCPSGRICRHMLAVFLYVYAMFE RVGTFTEYWLEREKLEESKELVRRQFQEKVLPNEESLSSWLAFFDSEFSLWQARTPEG SQNMQGLYYGYLSALKKHAPNKPELKSLYQIHSAIAVWLRMFTLIEAGKLNPEQDFYS LNPYVEQLMDTIYSSIDKLKTYALSFALDPFLDKTPDVIRHLLLKEEIFQYERIRVFG EIWSALLSRPKWVAREQEILKKEAGRRFSPELQFGRLHLEFLQKNDDVIFEEADQFPP EALPYTFQWLSEMTAKKDWKRLKTWYQQIEPIAMGYTKLDKPFKEIRDVIGELFLLLN AYVQQTNDQALFERFAAGCLPYTFTEYSHHLYEKKRYAEWIEIHSLVGFSINEMDKMM LKEIAASDPEALIPAYHREVAFFIDQKNRSSYKEAARYLKKLRTLYKKAKKQKVWERY IQLLSSHYKRLRALQEELQKGKLIDGES*" /label="ywqB CDS" gene 3197190..3198800 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /label="ywqB gene" promotor_-10 complement(3197292..3197310) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3197304) /Source="Nicolas_upshifts" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3197306..3197480) /Source="Nicolas_S_feature" /locus_tag="new_3733968_3734142_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, B60, C30" /AntisenseName="ywqB" /AntisenseCor="-0.10880748846525" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1397" promotor_-35 complement(3197324..3197331) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3197467..3197486) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3197480) /Source="Nicolas_upshifts" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3197500..3197508) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3198787..3201555 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9507009, 9614128, 11751638, 17913745, 19282450; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATPase involved in RNA remodelling DNA recombination and repair" /protein_id="NP_391509.1" /db_xref="EnsemblGenomes-Gn:BSU36280" /db_xref="EnsemblGenomes-Tr:CAB15645" /db_xref="GOA:P94593" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR022138" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12505" /db_xref="UniProtKB/Swiss-Prot:P94593" /translation="MASLKEILIHVEQMEDGSFTLSAFDENEQPLPYSHMKKHLFQWH ESSFYGTFLEDVSFIGTTAVLLSPWMTVELLGKNSFNSFSSVQLTEETEPLIEAASTI YEFIADGDFMPDYDAWTNGVFRWKDRDNILEGFTAEWFSAAVQDYIQYDDDLREKWEH IKEKSPAVTTFRGHFLDEEDFLEGIGWIDDQSPFTVGLRLNEPDFDGDEWKIEMFLRD KKSGAVEFFDGLKSLKKSWQAYSDKIAREQDRFHRTVPWLSFDSGTTLISEEEAWIFL SEASETLVDMGVEILLPSWWQIVRDSNMMLKAKVSSSPRGESFVGMNALLDFNWRFAT NGIELTEAEFNELVASNRRLVNIRGQWVKIDPQFIKQMKRLMEKAESEGLHMSDILAR ELMDQQDGGLEDSDLIDTSAFAGIQFDLSKQLRSLIRKLTAAENLPEHKVSPSFKGTL RPYQKYGMNWLLFLRESGFGACLADDMGLGKTIQMIAYFLHVKESGRQKTPHLIIAPT SVLGNWQRELQTFAPDLSVALHYGPRRPKGDDFAAHYENADVVLTSYGLSHADTEELS SVTWNTICLDEAQNIKNAHTKQSRAIRKLKGLHHIALSGTPMENRLTELWSIFDFMNK GYLGSLTGFHKRYVLPIEKDRDEKRIGQLQQLIRPFLLRRTKRDEEVALNLPEKLEEK EFIPLSAEQASLYEQLVKDTFDHMTSLTGMQRKALILSMLGRLKQICDHPALYLKEEQ TELLAGRSVKLEKLLELMTAIRAQNESCLIFTQYIQMGNMMKRLLEKTFGEPVQFLNG SLSKQERDTLVEKFQRKEYPTLILSLKAGGTGLNLTAANHVIHYDRWWNPAVENQATD RAYRIGQERFVHVHKMITTGTIEEKIDVMLESKQTLNDQIIQSENWITELSTQELEEL FTLSATAQ*" /label="hepA CDS" gene 3198787..3201555 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /label="hepA gene" downshifts complement(3201604) /Source="Nicolas_upshifts" /id="D1876" /incds=0 /nref=9 /ntot=202 /MaxReadThrough="1.80101" /MaxDrop="4.14573" /score="30.708119" /energy="-14.4" /TU="U2843" /idTUdmin="U2844" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3201681..3202538) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25848029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase of unidentified specificity (possibly promiscuous)" /protein_id="NP_391510.1" /db_xref="EnsemblGenomes-Gn:BSU36290" /db_xref="EnsemblGenomes-Tr:CAB15646" /db_xref="GOA:P94592" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:1NRW" /db_xref="SubtiList:BG12504" /db_xref="UniProtKB/Swiss-Prot:P94592" /translation="MKLIAIDLDGTLLNSKHQVSLENENALRQAQRDGIEVVVSTGRA HFDVMSIFEPLGIKTWVISANGAVIHDPEGRLYHHETIDKKRAYDILSWLESENYYYE VFTGSAIYTPQNGRELLDVELDRFRSANPEADLSVLKQAAEVQYSQSGFAYINSFQEL FEADEPIDFYNILGFSFFKEKLEAGWKRYEHAEDLTLVSSAEHNFELSSRKASKGQAL KRLAKQLNIPLEETAAVGDSLNDKSMLEAAGKGVAMGNAREDIKSIADAVTLTNDEHG VAHMMKHLL*" /label="ywpJ CDS" gene complement(3201681..3202538) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /label="ywpJ gene" CDS complement(3202544..3203320) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11491085" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11491085; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (glucose repression ofcatabolic operons)" /protein_id="NP_391511.1" /db_xref="EnsemblGenomes-Gn:BSU36300" /db_xref="EnsemblGenomes-Tr:CAB15647" /db_xref="GOA:P94591" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12503" /db_xref="UniProtKB/Swiss-Prot:P94591" /translation="MYQEERLVAILDFLKQHNRITTEQICTLLQVSRDTARRDLVKLE EQNAIIRTRGGAILPTVHQKIQSYSGRLKTVSEEKNKIGRLAASLIHDGDRVILDAST TVQACAKHLNAVDCTVITNSINLADVLSDKEGIEIYLLGGKLEKEHRFLYGSSVIEKL SSYHVDKALIGVVGISEHGITIAHEEDGMVKRKMIQQAKQVIALADHSKLGSTSFYQY AELNEIDLLITDRLPNQAFCDLLDRNGVELLVTEQDEGKD*" /label="glcR CDS" gene complement(3202544..3203320) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /label="glcR gene" promotor_-10 complement(3203346..3203365) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3203368) /Source="Nicolas_upshifts" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3203370..3203442) /Source="Nicolas_S_feature" /locus_tag="new_3740032_3740104_c" /HighExp="C30, GM 150, T-4.40H, G/S, C90, S2, T-5.40H, T-3.40H, T-2.40H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1398" promotor_-35 complement(3203380..3203387) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3203444..3203543) /Source="Nicolas_S_feature" /locus_tag="new_3740106_3740205_c" /HighExp="HiOs, S2, T-3.40H, T0.30H, C90, G/S, T1.0H, T0.0H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1399" downshifts complement(3203487) /Source="Nicolas_upshifts" /id="D1877" /incds=0 /nref=221 /ntot=258 /MaxReadThrough="3.81096" /MaxDrop="7.17295" /score="-7.00620083" /energy="-7.5" /TU="U2844" /idTUdmin="U2846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(3203544..3203885) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762004, 16009133, 16549871, 17630974, 25138221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762004, 16009133, 16549871, 17630974, 25138221; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391512.2" /db_xref="EnsemblGenomes-Gn:BSU36310" /db_xref="EnsemblGenomes-Tr:CAB15648" /db_xref="GOA:C0SPB6" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="PDB:3VDY" /db_xref="SubtiList:BG12502" /db_xref="UniProtKB/Swiss-Prot:C0SPB6" /translation="MFNQVMLVGRLTKDPDLRYTSAGAAVAHVTLAVNRSFKNASGEI EADYVNCTLWRKTAENTALYCQKGSLVGVSGRIQTRSYENEEGVNVYVTEVLADTVRF MDPKPREKAAD*" /label="ssbB CDS" gene complement(3203544..3203885) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /label="ssbB gene" promotor_-10 complement(3203907..3203926) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3203926) /Source="Nicolas_upshifts" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3203940..3203947) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3203962..3204345) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="interaction partner of DynA" /protein_id="NP_391513.1" /db_xref="EnsemblGenomes-Gn:BSU36320" /db_xref="EnsemblGenomes-Tr:CAB15649" /db_xref="SubtiList:BG12501" /db_xref="UniProtKB/Swiss-Prot:P94589" /translation="MNQFRLKEIYIDGVPSESHLIQKEVTYMLSRKEVFEVHLNKKGR ISFLYETQDGMEQYKIKLSMPEKKLSFQWFAWDGSSYVRMNTQNWLTKQIFFRFLKST YFFKGKKQKMFLAEGKMKTKDKNRG*" /label="ywpG CDS" gene complement(3203962..3204345) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /label="ywpG gene" promotor_-10 complement(3204367..3204386) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-10" misc_feature 3204374..3204393 /Source="Nicolas_upshift_promotors" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3204378 /Source="Nicolas_upshifts" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3204387) /Source="Nicolas_upshifts" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="upshifts" promotor_-35 complement(3204401..3204408) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-35" misc_feature 3204468..3204487 /Source="Nicolas_upshift_promotors" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3204471 /Source="Nicolas_upshifts" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3204520) /Source="Nicolas_upshifts" /id="D1878" /incds=0 /nref=2 /ntot=169 /MaxReadThrough="0.85282" /MaxDrop="4.02798" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2846" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS 3204520..3204930 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25663006" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391514.1" /db_xref="EnsemblGenomes-Gn:BSU36330" /db_xref="EnsemblGenomes-Tr:CAB15650" /db_xref="InterPro:IPR025573" /db_xref="SubtiList:BG12500" /db_xref="UniProtKB/Swiss-Prot:P94588" /translation="MKTFKLVDLNVERVDKEEQSIEQFPLIDGLIINKEDGENHWLIE ALVQKEHLSFFEQLQNSQSEAKVFVTITKKSNRPAQLTAAVKNIVKLEESIQVLLYGQ MVTRKQQGTETILESLVKEGYTGTKLIEAFKQKL*" /label="ywpF CDS" gene 3204520..3204930 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /label="ywpF gene" S_feature 3204931..3205014 /Source="Nicolas_S_feature" /locus_tag="new_3741593_3741676" /HighExp="BC, LBGtran, T3.30H, Etha, T2.0H, Lbtran, M9-stat, T3.0H, dia5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1400" downshifts 3204972 /Source="Nicolas_upshifts" /id="D1879" /incds=0 /nref=214 /ntot=260 /MaxReadThrough="1.83981" /MaxDrop="6.19197" /score="18.4023831" /energy="-14" /TU="NA" /idTUdmin="U2847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3205070..3205378) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 21800427, 21906378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sortase" /protein_id="NP_391515.1" /db_xref="EnsemblGenomes-Gn:BSU36340" /db_xref="EnsemblGenomes-Tr:CAB15651" /db_xref="GOA:P94587" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG12499" /db_xref="UniProtKB/Swiss-Prot:P94587" /translation="MRRDQKMGEGNYPLAGHHLKQKNLLFGPLENIKTGAQIVITDFK KDYIYSVTSKDIISEMDADVVEETNKKEITLITCDKAVKTEGRLVVKGELVDSFGHTN *" /label="ywpE CDS" gene complement(3205070..3205378) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /label="ywpE gene" downshifts complement(3205071) /Source="Nicolas_upshifts" /id="D1880" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="0.11027" /MaxDrop="2.8132" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2849" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS 3205722..3206558 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16740923; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative two-component sensor histidine kinase" /protein_id="NP_391516.1" /db_xref="EnsemblGenomes-Gn:BSU36350" /db_xref="EnsemblGenomes-Tr:CAB15652" /db_xref="GOA:P94586" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12498" /db_xref="UniProtKB/Swiss-Prot:P94586" /translation="MKIRERFSMVDLPVLIITAAIIGHDKYKAFHAGANDILQKPYHY SEFMARIQNLIMMKHTANQATRMEMAFLQSQIKPHFLYNVLNTIISLTHLDIEKAREV TEEFTNYLRMSFDFQNTSAISSFRHELSIINSYLSIEKTRFSNRLEVLFDIDEDIDFI LPPLMIQPLVENAVLHGVSKKRGGGWIKLTAKKQSKNEYHIKVEDNGPGITPEKQIDL LSTDFDRSVGLKNINQRLKHFCGSELMISSTPDAGTSVSMLIHLAETTGSPKELKDTE RT*" /label="ywpD CDS" gene 3205722..3206558 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /label="ywpD gene" promotor_-35 3205938..3205945 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3205960..3205979 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3205963 /Source="Nicolas_upshifts" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3206557 /Source="Nicolas_upshifts" /id="D1881" /incds=0 /nref=13 /ntot=132 /MaxReadThrough="0.11837" /MaxDrop="3.37937" /score="9.16906941" /energy="-8.6" /TU="NA" /idTUdmin="U2848" /TUdmin=154 /isTUend="FALSE" /label="downshifts" CDS complement(3206605..3206997) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /function="16.1: Circulate" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12948773, 15063854, 15165739, 16897034, 22685134, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12948773, 15063854, 15165739, 16897034, 22685134, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="large conductance mechanosensitive channel protein" /protein_id="NP_391517.1" /db_xref="EnsemblGenomes-Gn:BSU36360" /db_xref="EnsemblGenomes-Tr:CAB15653" /db_xref="GOA:P94585" /db_xref="InterPro:IPR001185" /db_xref="InterPro:IPR019823" /db_xref="InterPro:IPR036019" /db_xref="SubtiList:BG12497" /db_xref="UniProtKB/Swiss-Prot:P94585" /translation="MWNEFKAFAMRGNIVDLAIGVVIGGAFGKIVTSLVNDIIMPLVG LLLGGLDFSGLSFTFGDAVVKYGSFIQTIVNFLIISFSIFIVIRTLNGLRRKKEAEEE AAEEAVDAQEELLKEIRDLLKQQAKSPE*" /label="mscL CDS" gene complement(3206605..3206997) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /label="mscL gene" downshifts complement(3206611) /Source="Nicolas_upshifts" /id="D1882" /incds=0 /nref=216 /ntot=255 /MaxReadThrough="2.23487" /MaxDrop="6.5103" /score="28.9904077" /energy="-11.4" /TU="NA" /idTUdmin="U2849" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3207070..3207495) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /EC_number="4.2.1.59" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8910376, 12682299, 15194690, 15371447, 18093984, 22580319, 23322253, 27874013; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacyl-[acyl carrier protein] dehydratase" /protein_id="NP_391518.2" /db_xref="EnsemblGenomes-Gn:BSU36370" /db_xref="EnsemblGenomes-Tr:CAB15654" /db_xref="GOA:P94584" /db_xref="InterPro:IPR010084" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12496" /db_xref="UniProtKB/Swiss-Prot:P94584" /translation="MLDTQQIKEIIPHRYPFLLVDRITEVEEGKRAKGYKNVTANEEF FNGHFPQYPVMPGVLIVEALAQVGAVAMLIKEENRGRLAFFAGIDNCRFKKQVKPGDQ LHLEVEIIRARGTIGRGKGVATVDGEVVCEVELTFALGE*" /label="fabZ CDS" gene complement(3207070..3207495) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /label="fabZ gene" promotor_-10 complement(3207556..3207575) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3207572) /Source="Nicolas_upshifts" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3207574..3207658) /Source="Nicolas_S_feature" /locus_tag="new_3744236_3744320_c" /HighExp="Diami, dia5, Cold, dia15, H2O2, C30, Etha, Oxctl, Paraq, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigD, SigA" /TUlongPSig="0.999, 0.837" /label="S1401" promotor_-35 complement(3207590..3207597) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3207637 /Source="Nicolas_upshifts" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3207640..3207659 /Source="Nicolas_upshift_promotors" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3207650..3207669) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-10" upshifts complement(3207658) /Source="Nicolas_upshifts" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="upshifts" S_feature complement(3207660..3208744) /Source="Nicolas_S_feature" /locus_tag="new_3744322_3745406_c" /HighExp="Cold, C30, Lbstat, Glucon, Glu, Paraq, Pyr, H2O2, Fru, C90" /AntisenseName="rapD" /AntisenseCor="5.8390464430913601E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.837" /label="S1402" promotor_-35 complement(3207683..3207688) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-35" CDS 3207687..3208751 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391519.1" /db_xref="EnsemblGenomes-Gn:BSU36380" /db_xref="EnsemblGenomes-Tr:CAB15655" /db_xref="GOA:P94583" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11967" /db_xref="UniProtKB/Swiss-Prot:P94583" /translation="MISKFIEKRMLNMLDEWYSAMSKRKMNHVCTLKEKIDQHLPKIK KNTKLWMRYQLFQARHQLLFENQNGLDSLFDGLYGLEDKMDDELKYYLYFFSGLYEMV KTAPKHAVHHFKKAEQYLAAIHNTFEAADLYYQTAGAYYLMKSPPLSVQYVKKALHIY LHQFGYIKKVITCKLLLAVNYIDQERYEKAEQLFKEIIKKTQQLHDENLLCHAYYNLG FLKATEKKDQEALLYFRKVLKNQEFEMNSPVSYLHCVYESVRALFKTGNITEAKAVLQ KGKELSEKVDIQTIYLKLKTLEALYTSAEDPYEQLLEYVLELEKIEAWVDLEVLLEDI TEYYKKKDDFEKAAFFIMRG*" /label="rapD CDS" gene 3207687..3208751 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /label="rapD gene" S_feature 3208752..3209636 /Source="Nicolas_S_feature" /locus_tag="new_3745414_3746298" /HighExp="M9-stat, T4.0H, T2.0H, T3.30H, T2.30H, T3.0H, T1.30H, T5.0H, T1.0H, T0.30H" /AntisenseName="flhP" /AntisenseCor="-0.32116112580252298" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1403" CDS complement(3208774..3209583) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-basal body accessory protein" /protein_id="NP_391520.2" /db_xref="EnsemblGenomes-Gn:BSU36390" /db_xref="EnsemblGenomes-Tr:CAB15656" /db_xref="GOA:P39753" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10918" /db_xref="UniProtKB/Swiss-Prot:P39753" /translation="MLRSMLTASTTLNQLQQQIDTISSNLSNSNTTGYKAKDTNFSEL VRQQFDQVDEKNEEVAKARKTPPGLRLGVGAMMSSRLVSDQGSIQKTDRDLDIAFTSP YQYLQVNVNGNRQYTRDGALYVTPSAANANQLQLVTGNGYPVLDENGNTVNIDSSMKN ITINKNGTLTASDGNAVQRFNLGVVQVNNPQELKSEGNNLFSIDNAAAFEELNGANRQ NIGMQQGSLEMSNVDISEQMTDLITSQRSYQLNSRTITMGDQMLGLINSVR*" /label="flhP CDS" gene complement(3208774..3209583) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /label="flhP gene" downshifts complement(3208789) /Source="Nicolas_upshifts" /id="D1883" /incds=0 /nref=174 /ntot=256 /MaxReadThrough="4.65461" /MaxDrop="5.56507" /score="8.59904552" /energy="-7.4" /TU="U2853" /idTUdmin="U2854" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3209617..3210429) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1905667, 16621824, 22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905667, 16621824, 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body accessory rod protein" /protein_id="NP_391521.1" /db_xref="EnsemblGenomes-Gn:BSU36400" /db_xref="EnsemblGenomes-Tr:CAB15657" /db_xref="GOA:P39752" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10917" /db_xref="UniProtKB/Swiss-Prot:P39752" /translation="MLKGLYTATSAMIAQQRRTEMLSNNIANANTSGYKADQGSMRAF PEMLLSRIESKSPAGTSRTEIGSVNTGVYMQELKPLFTQGSLKSTDQPTDIALIENQV PMSAETNEKAALFYPVQTADGIRYSKSSTFSLNENNQLTINGRPILSTDRQPITVDNE NFTVSENGTVTTNGRTAGQIDVRMAEDVRNLKRDGNDLYSTADGNDLPSAAGNNQVAY SLKQGVSELSNVDVTSAYTEMTEAYRSFEANQKVIQAYDKSMDKAANEIGKI*" /label="flhO CDS" gene complement(3209617..3210429) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /label="flhO gene" S_feature complement(3210430..3210509) /Source="Nicolas_S_feature" /locus_tag="new_3747092_3747171_c" /HighExp="C90, Lbtran, Cold, GM-0.2, GM 15, GM 10, C30, GM 90, GM-0.1, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.999, 0.837" /TUlongSig="NA" /TUlongPSig="NA" /label="S1404" promotor_-35 3210460..3210467 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3210481..3210500 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3210490 /Source="Nicolas_upshifts" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3210503..3210521) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-10" upshifts complement(3210509) /Source="Nicolas_upshifts" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="upshifts" promotor_-35 complement(3210535..3210542) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-35" CDS complement(3210592..3211593) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="MreB-like morphogen" /protein_id="NP_391522.2" /db_xref="EnsemblGenomes-Gn:BSU36410" /db_xref="EnsemblGenomes-Tr:CAB15658" /db_xref="GOA:P39751" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10916" /db_xref="UniProtKB/Swiss-Prot:P39751" /translation="MFARDIGIDLGTANVLIHVKGKGIVLNEPSVVALDKNSGKVLAV GEEARRMVGRTPGNIVAIRPLKDGVIADFEVTEAMLKHFINKLNVKGLFSKPRMLICC PTNITSVEQKAIKEAAEKSGGKHVYLEEEPKVAAIGAGMEIFQPSGNMVVDIGGGTTD IAVISMGDIVTSSSIKMAGDKFDMEILNYIKREYKLLIGERTAEDIKIKVATVFPDAR HEEISIRGRDMVSGLPRTITVNSKEVEEALRESVAVIVQAAKQVLERTPPELSADIID RGVIITGGGALLNGLDQLLAEELKVPVLVAENPMDCVAIGTGVMLDNMDKLPKRKLS* " /label="mbl CDS" gene complement(3210592..3211593) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /label="mbl gene" downshifts complement(3210598) /Source="Nicolas_upshifts" /id="D1884" /incds=0 /nref=108 /ntot=240 /MaxReadThrough="5.6154" /MaxDrop="4.18076" /score="20.122637" /energy="-11.2" /TU="U2854" /idTUdmin="U2855" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" misc_feature complement(3211648..3211667) /Source="Nicolas_upshift_promotors" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3211672) /Source="Nicolas_upshifts" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="upshifts" S_feature complement(3211674..3211758) /Source="Nicolas_S_feature" /locus_tag="new_3748336_3748420_c" /HighExp="S5, S6, S4, S7, S8, S3, B36, T5.0H, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1405" CDS complement(3211759..3212040) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023218, 9324264, 15598884, 22720735, 24584501" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023218, 9324264, 15598884, 22720735, 24584501; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (stage III sporulation)" /protein_id="NP_391523.1" /db_xref="EnsemblGenomes-Gn:BSU36420" /db_xref="EnsemblGenomes-Tr:CAB15659" /db_xref="GOA:P15281" /db_xref="InterPro:IPR014208" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="PDB:2L0K" /db_xref="SubtiList:BG10408" /db_xref="UniProtKB/Swiss-Prot:P15281" /translation="MHDYIKERTIKIGKYIVETKKTVRVIAKEFGVSKSTVHKDLTER LPEINPDLANEVKEILDYHKSIRHLRGGEATKLKYKKDEILEGEPVQQS*" /label="spoIIID CDS" gene complement(3211759..3212040) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /label="spoIIID gene" CDS complement(3212055..3212165) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9023218; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative factor required for translation of spoIIID" /protein_id="NP_391524.1" /db_xref="EnsemblGenomes-Gn:BSU36430" /db_xref="EnsemblGenomes-Tr:CAB15660" /db_xref="SubtiList:BG11984" /db_xref="UniProtKB/Swiss-Prot:O32276" /translation="MGIFHKLTFKTIQRRSGIMNDSLQNTDLISHFSHPF*" /label="usd CDS" gene complement(3212055..3212165) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /label="usd gene" promotor_-10 complement(3212196..3212214) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3212218) /Source="Nicolas_upshifts" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3212230..3212235) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3212311..3212317 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3212331..3212350 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3212347 /Source="Nicolas_upshifts" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="upshifts" CDS 3212390..3212803 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391525.1" /db_xref="EnsemblGenomes-Gn:BSU36440" /db_xref="EnsemblGenomes-Tr:CAB15661" /db_xref="GOA:P94578" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12495" /db_xref="UniProtKB/Swiss-Prot:P94578" /translation="MSYVNRHLIHQINQSARLIAKKANEQLEPFGLYSSQWSVLYCLR TIGPMTQKEIWSYLNVEAPTVTRTIKRLEENGWVQRRQGEDKREKLVVLTKEAEKKYE EINVKMLKFEEELLADFRDEDKEAFSHLFRMFLQQ*" /label="ywoH CDS" gene 3212390..3212803 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /label="ywoH gene" CDS 3212825..3214015 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391526.1" /db_xref="EnsemblGenomes-Gn:BSU36450" /db_xref="EnsemblGenomes-Tr:CAB15662" /db_xref="GOA:P94577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12494" /db_xref="UniProtKB/Swiss-Prot:P94577" /translation="MKKADAIWTKDFIMVLLVNLFVFVFFYTFLTVLPIYTLQELGGT ESQGGLLISLFLLSAIITRPFSGAIVERFGKKRMAIVSMALFALSSFLYMPIHNFSLL LGLRFFQGIWFSILTTVTGAIAADIIPAKRRGEGLGYFAMSMNLAMAIGPFLGLNLMR VVSFPVFFTAFALFMVAGLLVSFLIKVPQSKDSGTTVFRFAFSDMFEKGALKIATVGL FISFCYSTVTSYLSVFAKSVDLSDISGYFFVCFAVTMMIARPFTGKLFDKVGPGIVIY PSILIFSVGLCMLSFTHSGLMLLLSGAVIGLGYGSIVPCMQTLAIQKSPAHRSGFATA TFFTFFDSGIAVGSYVFGLFVASAGFSAIYLTAGLFVLIALLLYTWSQKKPAEAEGKV SIAE*" /label="ywoG CDS" gene 3212825..3214015 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /label="ywoG gene" CDS complement(3214106..3215512) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15266115, 16607952, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pectin lyase" /protein_id="NP_391527.1" /db_xref="EnsemblGenomes-Gn:BSU36460" /db_xref="EnsemblGenomes-Tr:CAB15663" /db_xref="GOA:P94576" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12493" /db_xref="UniProtKB/Swiss-Prot:P94576" /translation="MRKWYFILLAGVLTSVILAFVYDKTKANEEGSGDYLYVSPNGSD QNEGTKEKPFRTLAHASEKAAAGTTVMIREGTYHETLDVKHSGTDGKPITFRNYENEN VVISGESVANAEYETPLIRIHDKHDIAISGLTIQDLSVSSEEATAIGIYVSGSSSHIA IKDNHIRGIKTTADEGNAHGIAVYGTGSMKDIRIEDNTVEKLTLGASEAVVLNGNIDG FTVAGNVVRNNNNIGIDLIGYEGTADKNDYVRNGVVENNTVYQNSTYGNPAYGDEYSA GGIYVDGGHDIEIKNNTVYDNDIGIEATSEHKGKYANAIQITDNKVYNNAYTGISIGG YDKKRGGTSNSLIARNIMYRNDTKGLYGGQLLLQYDTKNNTIEKNILTAGDSRLFIGN DFTENEGNTVNHNVYHKEADQDGIWMWKKKEYDSFSSYRKATKNDQQSIYADPMFRDE ASYDFSLDPDSPARPVIE*" /label="ywoF CDS" gene complement(3214106..3215512) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /label="ywoF gene" downshifts complement(3214403) /Source="Nicolas_upshifts" /id="D1885" /incds=1 /nref=1 /ntot=78 /MaxReadThrough="5.28695" /MaxDrop="2.1962" /score="4.73902293" /energy="-22.3" /TU="U2857" /idTUdmin="U2857" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3215545..3215564) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3215563) /Source="Nicolas_upshifts" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3215579..3215582) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3215618..3217090) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 15849754, 16850406, 26967546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 15849754, 16850406, 26967546; Product type t : transporter" /codon_start=1 /transl_table=11 /product="allantoin permease" /protein_id="NP_391528.1" /db_xref="EnsemblGenomes-Gn:BSU36470" /db_xref="EnsemblGenomes-Tr:CAB15664" /db_xref="GOA:P94575" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR012681" /db_xref="SubtiList:BG12492" /db_xref="UniProtKB/Swiss-Prot:P94575" /translation="MKLKESQQQSNRLSNEDLVPLGQEKRTWKAMNFASIWMGCIHNI PTYATVGGLIAIGLSPWQVLAIIITASLILFGALALNGHAGTKYGLPFPVIIRASYGI YGANIPALLRAFTAIMWLGIQTFAGSTALNILLLNMWPGWGEIGGEWNILGIHLSGLL SFVFFWAIHLLVLHHGMESIKRFEVWAGPLVYLVFGGMVWWAVDIAGGLGPIYSQPGK FHTFSETFWPFAAGVTGIIGIWATLILNIPDFTRFAETQKEQIKGQFYGLPGTFALFA FASITVTSGSQVAFGEPIWDVVDILARFDNPYVIVLSVITLCIATISVNVAANIVSPA YDIANALPKYINFKRGSFITALLALFTVPWKLMESATSVYAFLGLIGGMLGPVAGVMM ADYFIIRKRELSVDDLYSETGRYVYWKGYNYRAFAATMLGALISLIGMYVPVLKSLYD ISWFVGVLISFLFYIVLMRVHPPASLAIETVEHAQVRQAE*" /label="pucI CDS" gene complement(3215618..3217090) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /label="pucI gene" CDS complement(3217271..3218629) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391529.1" /db_xref="EnsemblGenomes-Gn:BSU36480" /db_xref="EnsemblGenomes-Tr:CAB15665" /db_xref="GOA:P94574" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12491" /db_xref="UniProtKB/Swiss-Prot:P94574" /translation="MLSKKSRAVFLTAVASGTMLNPLNSSMISLALHSIQHEFHLSFT TVSWLISSFYLASAVAQPVTGKLGDLIGRKRLFLFGLILVAVSAIGAPFAPTFMTLLV MRLFQSVGSSAIYPSGVGLIRNHIHERQASALAVLSIFASAMTALGPTAGGFLIVWGG WPAIFIVNLPFIILSFLLGLYMFPKDQKKGAGIKTIIRQLDILGIVLFAGGIIFLLSF LLSFSTSPHAVEGVLGLLLLCAFVWRELKTDKPFIDVRLFKTQRNLSAVYVQFILLNV FFYCLFFGLPSYFQDEMHLSVQTSGLFMLFMSGMSIVVSPLTGKWIDRSGVVKPIFAG ALLMTAGAVLLTIFFINVQTIGKGLILSLLGIGYGLGNVALQAAMLETSPSNMVGTTS GLFQTCRYLGSILSSVILGILFGKEITAAHFDMMGIIMIIAGGASLLMAVRFAALMKT AS*" /label="ywoD CDS" gene complement(3217271..3218629) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /label="ywoD gene" downshifts complement(3217285) /Source="Nicolas_upshifts" /id="D1886" /incds=0 /nref=58 /ntot=198 /MaxReadThrough="1.44148" /MaxDrop="4.13092" /score="20.2036192" /energy="-12.8" /TU="NA" /idTUdmin="U2858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3218629..3219198) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of isochorismatase family" /protein_id="NP_391530.2" /db_xref="EnsemblGenomes-Gn:BSU36490" /db_xref="EnsemblGenomes-Tr:CAB15666" /db_xref="GOA:P94573" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12490" /db_xref="UniProtKB/Swiss-Prot:P94573" /translation="MMNTLNIDFQKTALVIIDLQKGIVPIDQSGQVVPNAKKLVDEFR KHNGFISFVNVAFHDGADALKPQTDEPAQGGSGEMPADWAEFVPEIGVQDGDYTVTKR QWGAFFGTDLDLQLRRRGIDTIVLCGIATNIGVESTAREAFQLGYQQIFITDAMSTFS DEEHEATLRFIFPRIGKSRTTEEFLEQVK*" /label="ywoC CDS" gene complement(3218629..3219198) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /label="ywoC gene" promotor_-10 complement(3219217..3219228) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3219235) /Source="Nicolas_upshifts" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3219242..3219248) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3219305..3219472) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CCQ48605.1" /translation="MSYPALDGPPQIHGHFQAGTDRQQAGDEAMTPFMITVLAGLFVC TTCYYYIKEKS*" /label="hypothetical protein CDS" gene complement(3219305..3219472) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /pseudo /label="gene" CDS complement(3219382..3219846) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21856850; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391531.1" /db_xref="EnsemblGenomes-Gn:BSU36500" /db_xref="EnsemblGenomes-Tr:CAB15667" /db_xref="GOA:P94572" /db_xref="InterPro:IPR020218" /db_xref="SubtiList:BG12489" /db_xref="UniProtKB/Swiss-Prot:P94572" /translation="MMNKGGRLRKAVRKSIPATFRLFLAFNFFVYGLAKVVIGQFGEV TPEIEAAAGKGFTIAWTFFGYSHVYELFIGFGEILAAVLLLIPRTAALGAVIFMPIIV NIVLINYCFDIGVQDLSTILMVMCLILLWMDRRKFMGIFRQEPIDSRQVMKR*" /label="ywoB CDS" gene complement(3219382..3219846) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /label="ywoB gene" promotor_-10 complement(3219876..3219895) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3219881) /Source="Nicolas_upshifts" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3219909..3219916) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3220047..3220050 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3220065..3220084 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3220069 /Source="Nicolas_upshifts" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3220128..3221342 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 15849754, 16850406, 17001076, 21435182" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 15849754, 16850406, 17001076, 21435182; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ammonium transporter" /protein_id="NP_391532.1" /db_xref="EnsemblGenomes-Gn:BSU36510" /db_xref="EnsemblGenomes-Tr:CAB15668" /db_xref="GOA:Q07429" /db_xref="InterPro:IPR001905" /db_xref="InterPro:IPR018047" /db_xref="InterPro:IPR024041" /db_xref="InterPro:IPR029020" /db_xref="SubtiList:BG10869" /db_xref="UniProtKB/Swiss-Prot:Q07429" /translation="MQMGDTVFMFFCALLVWLMTPGLALFYGGMVKSKNVLSTAMHSF SSIAIVSIVWVLFGYTLAFAPGNSIIGGLEWAGLKGVGFDPGDYSDTIPHSLFMMFQM TFAVLTTAIISGAFAERMRFGAFLLFSVLWASLVYTPVAHWVWGGGWIGQLGALDFAG GNVVHISSGVAGLVLAIVLGKRKDGTASSPHNLIYTFLGGALIWFGWFGFNVGSALTL DGVAMYAFINTNTAAAAGIAGWILVEWIINKKPTMLGAVSGAIAGLVAITPAAGFVTP FASIIIGIIGGAVCFWGVFSLKKKFGYDDALDAFGLHGIGGTWGGIATGLFATTSVNS AGADGLFYGDASLIWKQIVAIAATYVFVFIVTFVIIKIVSLFLPLRATEEEESLGLDL TMHGEKAYQDSM*" /label="amtB CDS" gene 3220128..3221342 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /label="amtB gene" promotor_-10 complement(3220958..3220976) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3220959) /Source="Nicolas_upshifts" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3220990..3220997) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3221208..3221214 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3221228..3221247 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3221230 /Source="Nicolas_upshifts" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3221354..3221704 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 17001076, 21435182, 23461034, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen-regulated PII-like regulator protein" /protein_id="NP_391533.1" /db_xref="EnsemblGenomes-Gn:BSU36520" /db_xref="EnsemblGenomes-Tr:CAB15669" /db_xref="GOA:Q07428" /db_xref="InterPro:IPR002187" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017918" /db_xref="PDB:4R25" /db_xref="PDB:4RX6" /db_xref="SubtiList:BG10870" /db_xref="UniProtKB/Swiss-Prot:Q07428" /translation="MSGQMFKVEIVTRPANFEKLKQELGKIGVTSLTFSNVHGCGLQK AHTELYRGVKIESNVYERLKIEIVVSKVPVDQVTETAKRVLKTGSPGDGKIFVYEISN TINIRTGEEGPEAL*" /label="glnK CDS" gene 3221354..3221704 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /label="glnK gene" downshifts 3221697 /Source="Nicolas_upshifts" /id="D1887" /incds=0 /nref=179 /ntot=251 /MaxReadThrough="2.13701" /MaxDrop="8.63831" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2860" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3221756..3221764 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3221778..3221786 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3221785 /Source="Nicolas_upshifts" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3221827..3221836 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3221849..3221864 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3221853 /Source="Nicolas_upshifts" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" CDS 3221885..3222466 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /EC_number="3.6.1.27" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate phosphatase (bacitracin resistance)" /protein_id="NP_391534.1" /db_xref="EnsemblGenomes-Gn:BSU36530" /db_xref="EnsemblGenomes-Tr:CAB15670" /db_xref="GOA:P94571" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR033879" /db_xref="InterPro:IPR036938" /db_xref="SubtiList:BG12488" /db_xref="UniProtKB/Swiss-Prot:P94571" /translation="MNYEIFKAIHGLSHHNSVLDSIMVFITEYAIVAYALILLAIWLF GNTQSRKHVLYAGITGIAGLVINYLITLVYFEPRPFVAHTVHTLIPHAADASFPSDHT TGALAISIAMLFRNRKIGWPLVIFGLLTGFSRIWVGHHYPVDVLGSLVVAIIIGFLFF RFSDLLRPFVDLVVRIYEAIINKLTKKPTDQNF*" /label="bcrC CDS" gene 3221885..3222466 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /label="bcrC gene" promotor_-10 complement(3221983..3222002) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3221993) /Source="Nicolas_upshifts" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3222016..3222024) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3222447 /Source="Nicolas_upshifts" /id="D1888" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.1929" /MaxDrop="6.53316" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2863" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(3222507..3222929) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14762009, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391535.1" /db_xref="EnsemblGenomes-Gn:BSU36540" /db_xref="EnsemblGenomes-Tr:CAB15671" /db_xref="GOA:P71045" /db_xref="InterPro:IPR006976" /db_xref="SubtiList:BG12487" /db_xref="UniProtKB/Swiss-Prot:P71045" /translation="MNRLLLAGWIFFILLSVCTESFSGMVVSQTVAFHFQPHPDLSQF LVMDFTELTVPEAFIQKIGHAFSFFVLTYLLWKQRGSIRSAAAGSFAFAFFTEVLQLF FSRNGCIRDVLIDAVGIGLFYGLYVLAKRRKQEMYEKY*" /label="ywnJ CDS" gene complement(3222507..3222929) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /label="ywnJ gene" downshifts complement(3222526) /Source="Nicolas_upshifts" /id="D1889" /incds=0 /nref=9 /ntot=75 /MaxReadThrough="0.80227" /MaxDrop="3.65224" /score="4.98901321" /energy="-13.6" /TU="NA" /idTUdmin="U2869" /TUdmin=215 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3222964..3222979) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3222983) /Source="Nicolas_upshifts" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3222992..3223001) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3223040..3223891) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /function="16.8: Protect" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore protein required for alternative engulfment" /protein_id="NP_391536.1" /db_xref="EnsemblGenomes-Gn:BSU36550" /db_xref="EnsemblGenomes-Tr:CAB15672" /db_xref="GOA:P71044" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11978" /db_xref="UniProtKB/Swiss-Prot:P71044" /translation="MREEEKKTSQVKKLQQFFRKRWVFPAIYLVSAAVILTAVLWYQS VSNDEVKDQLADNGGNSAYDNNDDAVEVGKSMENVAMPVVDSENVSVVKKFYETDAAK EEKEAALVTYNNTYSLSKGIDLAEKDGKDFDVSASLSGTVVKAEKDPVLGYVVEVEHA DGLSTVYQSLSEVSVEQGDKVKQNQVIGKSGKNLYSEDSGNHVHFEIRKDGVAMNPLN FMDKPVSSIEKAATQETEESIQQSSEKKDGSTEKGTEEKSGEKKDDSTDKSGSKESST TEDTEQS*" /label="spoIIQ CDS" gene complement(3223040..3223891) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /label="spoIIQ gene" downshifts complement(3223049) /Source="Nicolas_upshifts" /id="D1890" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.592" /MaxDrop="5.16472" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts complement(3223291) /Source="Nicolas_upshifts" /id="D1891" /incds=1 /nref=4 /ntot=59 /MaxReadThrough="6.6416" /MaxDrop="3.0034" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" promotor_-35 3223528..3223530 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3223547..3223566 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3223548..3223894 /Source="Nicolas_S_feature" /locus_tag="new_3760210_3760556" /HighExp="LBGstat, LBGtran, Cold, Sw, dia15, C30, G180, Lbexp, LBGexp, UNK1" /AntisenseName="spoIIQ" /AntisenseCor="-0.81767802234568998" /AntisenseRegPval="-65.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1406" upshifts 3223548 /Source="Nicolas_upshifts" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3223886..3223889 /Source="Nicolas_upshift_promotors" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3223896..3224031 /Source="Nicolas_S_feature" /locus_tag="new_3760558_3760693" /HighExp="LBGstat, S8, LBGtran, Sw, LoTm, BC, Cold, S7, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.122, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1407" upshifts 3223896 /Source="Nicolas_upshifts" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3223925) /Source="Nicolas_upshifts" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3223931..3223940) /Source="Nicolas_upshift_promotors" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3224032..3224523 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /EC_number="2.3.1.183" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 16021622, 27694229; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacid analogs (phosphinothricin) N-acetyltransferase" /protein_id="NP_391537.1" /db_xref="EnsemblGenomes-Gn:BSU36560" /db_xref="EnsemblGenomes-Tr:CAB15673" /db_xref="GOA:P71043" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1VHS" /db_xref="SubtiList:BG12486" /db_xref="UniProtKB/Swiss-Prot:P71043" /translation="MTLRLAEHRDLEAVVAIYNSTIASRMVTADTEPVTPEDRMEWFS GHTESRPLYVAEDENGNVAAWISFETFYGRPAYNKTAEVSIYIDEACRGKGVGSYLLQ EALRIAPNLGIRSLMAFIFGHNKPSLKLFEKHGFAEWGLFPGIAEMDGKRYDLKILGR ELS*" /label="ywnH CDS" gene 3224032..3224523 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /label="ywnH gene" promotor_-35 3224261..3224266 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3224282..3224300 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3224293 /Source="Nicolas_upshifts" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3224384..3225292) /Source="Nicolas_S_feature" /locus_tag="new_3761046_3761954_c" /HighExp="H2O2, dia15, Diami, dia5, S8, Paraq, G180, G135, C30, G150" /AntisenseName="ywnG" /AntisenseCor="0.27407310266030799" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S1408" CDS 3224520..3225038 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391538.1" /db_xref="EnsemblGenomes-Gn:BSU36570" /db_xref="EnsemblGenomes-Tr:CAB15674" /db_xref="GOA:P71042" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12485" /db_xref="UniProtKB/Swiss-Prot:P71042" /translation="MISLDKDENEIEHHNEENSLVEQETAPVGQESRQLSASAVKSLS DIAKWGKISGILLIIMGSLVTLSVLMTVIGAIPGVLLIISGVFLMRSAKAAAEAEGNL TGSAGESMLENYGTFIKMQLFYAASSIVTVLIGIIVAIFVLVVIGIAAFENTPSYDDP DSYYYEDDPVFE*" /label="ywnG CDS" gene 3224520..3225038 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /label="ywnG gene" downshifts 3224843 /Source="Nicolas_upshifts" /id="D1892" /incds=1 /nref=1 /ntot=29 /MaxReadThrough="4.194" /MaxDrop="1.82458" /score="-3.39058903" /energy="-13.3" /TU="U2867,U2868,U2870" /idTUdmin="U2868" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 3225041 /Source="Nicolas_upshifts" /id="D1893" /incds=0 /nref=3 /ntot=133 /MaxReadThrough="2.87136" /MaxDrop="2.9486" /score="-3.39058903" /energy="-13.3" /TU="U2867" /idTUdmin="U2870" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3225197..3225328 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514007.1" /translation="MNIKKTDEVGINPKPHFLFRVSACKKTHPDRLENLNNPGADLL* " /label="hypothetical protein CDS" gene 3225197..3225328 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /label="gene" CDS complement(3225325..3225759) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391539.1" /db_xref="EnsemblGenomes-Gn:BSU36580" /db_xref="EnsemblGenomes-Tr:CAB15675" /db_xref="GOA:P71041" /db_xref="InterPro:IPR020205" /db_xref="SubtiList:BG12484" /db_xref="UniProtKB/Swiss-Prot:P71041" /translation="MNFYRVEQMPGFIKTEMQKIQKAVQPFMKKTVIYRFLAIPLAAF SLFNLAAFLFHASADRESLISAGIFALLAALGLAFFKEAGYQHKQIQKTVHIYMLNRI KKSEILSEERKSSYARQIKEEPFAMRSFVEFLTEEDRRKKMY*" /label="ywnF CDS" gene complement(3225325..3225759) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /label="ywnF gene" downshifts complement(3225337) /Source="Nicolas_upshifts" /id="D1894" /incds=0 /nref=174 /ntot=254 /MaxReadThrough="4.22489" /MaxDrop="5.35802" /score="21.5198482" /energy="-21.3" /TU="U2871" /idTUdmin="U2873" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3225808..3225827) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3225815) /Source="Nicolas_upshifts" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3225817..3226114) /Source="Nicolas_S_feature" /locus_tag="new_3762479_3762776_c" /HighExp="Etha, S6, S3, S4, S8, S5, S7, M9-stat, Sw, Salt" /AntisenseName="clsA" /AntisenseCor="-0.16109419145114601" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF" /TUshortPSig="0.99, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1409" promotor_-35 complement(3225842..3225849) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3225888..3225892 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3225909..3225928 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3225921..3226001 /Source="Nicolas_S_feature" /locus_tag="new_3762583_3762663" /HighExp="LBGstat, Diami, dia15, G180, Oxctl, H2O2, T0.30H, S8, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1410" upshifts 3225922 /Source="Nicolas_upshifts" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3226002..3227450 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14973018, 16755131, 18820022, 26708983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16755131, 18820022, 26708983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cardiolipin synthase (major)" /protein_id="NP_391540.1" /db_xref="EnsemblGenomes-Gn:BSU36590" /db_xref="EnsemblGenomes-Tr:CAB15676" /db_xref="GOA:P71040" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG12483" /db_xref="UniProtKB/Swiss-Prot:P71040" /translation="MSISSILLSLFFILNILLAIIVIFKERRDASASWAWLLVLFFIP VLGFILYLLFGHNLRRKHLFQWEDRKKIGIERLLKHQLEDLETKQFQFNNRATFDNKD LIYMLIMNNHAVFTEDNSVDVITDGRDKFQRLLSDISKAKDHIHLQYYIYKGDELGKK LRDALIQKAKEGVQVRVLYDELGSRTLRKKFFKELREAGGHVEVFFPSKLRPINLRLN YRNHRKLVIIDGMTGYVGGFNVGDEYLGLNPKFGYWRDTHIRLQGTAVHAIQTRFILD WNQASHHHTLTYIPNHFPDYGPKGNVGMQIVTSGPDSEWEQIKNGYIKMISNAKRSIL IQTPYFIPDASLLDALRIACLSGIDVNIMIPNKPDHAFVYWATLSYIGDLLKAGATVY IYDNGFIHAKTIVVDDEIASVGTANIDVRSFRLNFEVNAFIYDITIAKKLVSTFKEDL LVSRKFTYEEYLQRPLWIRIKESVSRLLSPIL*" /label="clsA CDS" gene 3226002..3227450 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /label="clsA gene" upshifts complement(3226114) /Source="Nicolas_upshifts" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3226115..3226133) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3226116..3226459) /Source="Nicolas_S_feature" /locus_tag="new_3762778_3763121_c" /HighExp="S6, S8, S4, S5, S7, S3, T5.0H, M9-stat, C30, T4.0H" /AntisenseName="clsA" /AntisenseCor="3.3648966966722899E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1411" promotor_-35 complement(3226149..3226155) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3226437..3226455) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3226459) /Source="Nicolas_upshifts" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3226471..3226476) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3227439 /Source="Nicolas_upshifts" /id="D1895" /incds=0 /nref=6 /ntot=214 /MaxReadThrough="0.7051" /MaxDrop="4.44298" /score="26.7449315" /energy="-19.5" /TU="NA" /idTUdmin="U2872" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3227471..3228244) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10200972, 11581256, 18502870" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 11581256, 18502870; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulating efflux transporters synthesis (Fur-independent bacillibactin export)" /protein_id="NP_391541.1" /db_xref="EnsemblGenomes-Gn:BSU36600" /db_xref="EnsemblGenomes-Tr:CAB15677" /db_xref="GOA:P71039" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012925" /db_xref="InterPro:IPR036244" /db_xref="PDB:1JBG" /db_xref="PDB:1R8D" /db_xref="SubtiList:BG12482" /db_xref="UniProtKB/Swiss-Prot:P71039" /translation="MKYQVKQVAEISGVSIRTLHHYDNIELLNPSALTDAGYRLYSDA DLERLQQILFFKEIGFRLDEIKEMLDHPNFDRKAALQSQKEILMKKKQRMDEMIQTID RTLLSVDGGETMNKRDLFAGLSMKDIEEHQQTYADEVRKLYGKEIAEETEKRTSAYSA DDWRTIMAEFDSIYRRIAARMKHGPDDAEIQAAVGAFRDHICQYHYDCTLDIFRGLGE VYITDERFTDSINQYGEGLAAFLREAIIIYCDHQENPRP*" /label="mta CDS" gene complement(3227471..3228244) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /label="mta gene" downshifts complement(3227493) /Source="Nicolas_upshifts" /id="D1896" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="0.46006" /MaxDrop="2.97389" /score="11.4339746" /energy="-19.5" /TU="NA" /idTUdmin="U2876" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" promotor_-35 3228319..3228322 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3228338..3228357 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3228342 /Source="Nicolas_upshifts" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="upshifts" CDS 3228389..3228772 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391542.1" /db_xref="EnsemblGenomes-Gn:BSU36610" /db_xref="EnsemblGenomes-Tr:CAB15678" /db_xref="GOA:P71038" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12481" /db_xref="UniProtKB/Swiss-Prot:P71038" /translation="MNPETMNKTLISISKWGKATGILFIIMGAITALSGAFFFLIGAV PGVLQIISGIFLMRSAREAGQMAEHNSGQSEDLMLENYAKFVKMQGIYLIVSIAVSIL AIIAFFIFLMLGIADGLFSDTYSTY*" /label="ywnC CDS" gene 3228389..3228772 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /label="ywnC gene" downshifts 3228759 /Source="Nicolas_upshifts" /id="D1897" /incds=0 /nref=60 /ntot=180 /MaxReadThrough="1.0319" /MaxDrop="4.45212" /score="35.5991488" /energy="-11.4" /TU="NA" /idTUdmin="U2875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3228807..3229448) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391543.1" /db_xref="EnsemblGenomes-Gn:BSU36620" /db_xref="EnsemblGenomes-Tr:CAB15679" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12480" /db_xref="UniProtKB/Swiss-Prot:P71037" /translation="MKIGIIGASGKAGNEILKEAKKRGHEVTAIVRNASKVQEQDVAI LEKDVFELTAEDIKPFDAVVNAFGAAPGQEHLHVEAGRALISILKDAKHTRLLVVGGA GSLFVDEAKTTRLMDTPEFPKEYLPTASNQGENLKDLQQTDSISWTFLSPAAFFDPAG KRTGSYQKGKDNVIVNAKGDSYISYADYAIAVLDELEHPEHKNERFTVVSEAE*" /label="ywnB CDS" gene complement(3228807..3229448) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /label="ywnB gene" downshifts complement(3228857) /Source="Nicolas_upshifts" /id="D1898" /incds=0 /nref=20 /ntot=170 /MaxReadThrough="3.62026" /MaxDrop="4.98934" /score="21.1363072" /energy="-11.4" /TU="U2876" /idTUdmin="U2876" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(3229516..3229917) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391544.1" /db_xref="EnsemblGenomes-Gn:BSU36630" /db_xref="EnsemblGenomes-Tr:CAB15680" /db_xref="GOA:P71036" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1XD7" /db_xref="SubtiList:BG12479" /db_xref="UniProtKB/Swiss-Prot:P71036" /translation="MINSRLAVAIHILSLISMDEKTSSEIIADSVNTNPVVVRRMISL LKKADILTSRAGVPGASLKKDPADISLLEVYRAVQKQEELFAVHENPNPKCPVGKKIQ NALDETFESVQRAMENELASKSLKDVMNHLF*" /label="ywnA CDS" gene complement(3229516..3229917) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /label="ywnA gene" promotor_-10 complement(3229966..3229985) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3229976) /Source="Nicolas_upshifts" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3229978..3230051) /Source="Nicolas_S_feature" /locus_tag="new_3766640_3766713_c" /HighExp="BT, Etha, S1, B60, LoTm, B36, S2, Glucon, Sw, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.18507799999999999" /TUshortSig="Sig-" /TUshortPSig="0.106" /TUlongSig="SigH, SigA, SigB, SigB" /TUlongPSig="1, 0.993, 1, 0.995" /label="S1412" promotor_-35 complement(3230000..3230005) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3230052..3231761) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (alpha subunit)" /protein_id="NP_391545.1" /db_xref="EnsemblGenomes-Gn:BSU36640" /db_xref="EnsemblGenomes-Tr:CAB15681" /db_xref="GOA:P77837" /db_xref="InterPro:IPR005848" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR011612" /db_xref="InterPro:IPR017950" /db_xref="InterPro:IPR017951" /db_xref="InterPro:IPR029754" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11983" /db_xref="UniProtKB/Swiss-Prot:P77837" /translation="MKMSREEYAELFGPTTGDKIRLGDTDLWIEVEKDFTVYGEEMIF GGGKTIRDGMGQNGRITGKDGALDLVITNVVLLDYTGIVKADVGVKDGRIVGVGKSGN PDIMDGVDPHMVIGAGTEVISGEGKILTAGGVDTHIHFICPQQMEVALSSGVTTLLGG GTGPATGSKATTCTSGAWYMARMLEAAEEFPINVGFLGKGNASDKAPLIEQVEAGAIG LKLHEDWGTTPSAIKTCMEVVDEADIQVAIHTDTINEAGFLENTLDAIGDRVIHTYHI EGAGGGHAPDIMKLASYANILPSSTTPTIPYTVNTMDEHLDMMMVCHHLDAKVPEDVA FSHSRIRAATIAAEDILHDIGAISMTSSDSQAMGRVGEVIIRTWQVADKMKKQRGALA GENGNDNVRAKRYIAKYTINPAITHGLSHEVGSVEKGKLADLVLWDPVFFGVKPELVL KGGMIARAQMGDPNASIPTPEPVFMRQMYASYGKANRSTSITFMSQASIERGVAESLG LEKRISPVKNIRKLSKLDMKLNSALPKIEIDPKTYQVFADGEELSCQPVDYVPLGQRY FLF*" /label="ureC CDS" gene complement(3230052..3231761) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /label="ureC gene" CDS complement(3231758..3232132) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (beta subunit)" /protein_id="NP_391546.1" /db_xref="EnsemblGenomes-Gn:BSU36650" /db_xref="EnsemblGenomes-Tr:CAB15682" /db_xref="GOA:P71035" /db_xref="InterPro:IPR002019" /db_xref="InterPro:IPR036461" /db_xref="SubtiList:BG11982" /db_xref="UniProtKB/Swiss-Prot:P71035" /translation="MKPGAFQIAEGTITINEGREIREVTVKNTGSRSIQVGSHFHFAE ANGALLFDRELAIGMRLDVPSGTSVRFEPGEQKTVSLVEIRGRKTIRGLNGMADTFID ERGKEKTLANLKQAGWMEGVIR*" /label="ureB CDS" gene complement(3231758..3232132) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /label="ureB gene" CDS complement(3232129..3232446) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /EC_number="3.5.1.5" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (gamma subunit)" /protein_id="NP_391547.1" /db_xref="EnsemblGenomes-Gn:BSU36660" /db_xref="EnsemblGenomes-Tr:CAB15683" /db_xref="GOA:P75030" /db_xref="InterPro:IPR002026" /db_xref="InterPro:IPR012010" /db_xref="InterPro:IPR036463" /db_xref="SubtiList:BG11981" /db_xref="UniProtKB/Swiss-Prot:P75030" /translation="MKLTPVEQEKLLIFAAGELAKQRKARGVLLNYPEAAAYITCFIM EGARDGKGVAELMEAGRHVLTEKDVMEGVPEMLDSIQVEATFPDGVKLVTVHQPISAE VKS*" /label="ureA CDS" gene complement(3232129..3232446) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /label="ureA gene" S_feature complement(3232447..3232531) /Source="Nicolas_S_feature" /locus_tag="new_3769109_3769193_c" /HighExp="BT, B60, B36, S1, Etha, LoTm, M9-stat, S2, T0.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigH, SigB" /TUshortPSig="0.106, 1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1413" upshifts complement(3232531) /Source="Nicolas_upshifts" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3232533..3232546) /Source="Nicolas_upshift_promotors" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(3232533..3232626) /Source="Nicolas_S_feature" /locus_tag="new_3769195_3769288_c" /HighExp="BT, Etha, B60, S1, B36, BC, S2, LoTm, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30781199999999997" /TUshortSig="SigH, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1414" CDS complement(3232627..3232791) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (putative phage interference protein)" /protein_id="YP_009514008.1" /translation="MVNLKNILLNKQLEGIQILIVELVRQVIIEISRKKDICYLSRAQ SGKRVNLIFP*" /label="ywzE CDS" gene complement(3232627..3232791) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /label="ywzE gene" promotor_-10 complement(3232714..3232732) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-10" upshifts complement(3232726) /Source="Nicolas_upshifts" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="upshifts" promotor_-35 complement(3232744..3232752) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-35" S_feature complement(3232792..3232963) /Source="Nicolas_S_feature" /locus_tag="new_3769454_3769625_c" /HighExp="Etha, BT, S1, GM-0.2, GM-0.1, Salt, GM 5, T-5.40H, MG 60, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1415" CDS complement(3232964..3233146) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="PSEUDO:CAX52705.1" /translation="MKAGILHSLRGTVAISEVTVHDAELMAIVGFSVSWRSAPQTGLH AMLPVAEQNNGLPSGM*" /label="ywzF CDS" gene complement(3232964..3233146) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /pseudo /label="ywzF gene" S_feature complement(3233147..3233293) /Source="Nicolas_S_feature" /locus_tag="new_3769809_3769955_c" /HighExp="Etha, BT, S1, Salt, GM-0.2, GM-0.1, M9-stat, GM 5, GM 45, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15897800000000001" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1416" promotor_-10 complement(3233281..3233300) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3233293) /Source="Nicolas_upshifts" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" S_feature complement(3233295..3233409) /Source="Nicolas_S_feature" /locus_tag="new_3769957_3770070_c" /HighExp="Etha, Salt, M9-stat, S8, B60, B36, Sw, Gly, LoTm, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1417" promotor_-35 complement(3233315..3233322) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" Polymorphism join(3233396,3233398) /Source="geneious" /ID="SNP_BsDelta6_3770059_3770058" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)8 -> (A)9" /Codon_Change /Coverage=64 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="2.1e-197" /Variant_Raw_Frequency=61 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 3233423 /Source="Nicolas_upshifts" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3233426..3233430 /Source="Nicolas_upshift_promotors" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3233443..3233631) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10376822, 11988534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376822, 11988534; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein" /protein_id="NP_391548.1" /db_xref="EnsemblGenomes-Gn:BSU36670" /db_xref="EnsemblGenomes-Tr:CAB15684" /db_xref="InterPro:IPR008462" /db_xref="InterPro:IPR036629" /db_xref="SubtiList:BG12478" /db_xref="UniProtKB/Swiss-Prot:P70964" /translation="MGNDSVKDKMKGGFNKAKGEVKDKVGDMADRTDMQAEGKKDKAK GEIQKDIGKAKDKFSDKD*" /label="csbD CDS" gene complement(3233443..3233631) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /label="csbD gene" downshifts complement(3233454) /Source="Nicolas_upshifts" /id="D1899" /incds=0 /nref=69 /ntot=139 /MaxReadThrough="6.39376" /MaxDrop="6.75256" /score="21.8463823" /energy="-10.2" /TU="U2881" /idTUdmin="U2882" /TUdmin=221 /isTUend="FALSE" /label="downshifts" downshifts 3233621 /Source="Nicolas_upshifts" /id="D1900" /incds=0 /nref=15 /ntot=36 /MaxReadThrough="0.59322" /MaxDrop="5.27268" /score="-5.47050177" /energy="-8.1" /TU="NA" /idTUdmin="U2880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3233657..3233675) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3233668) /Source="Nicolas_upshifts" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3233689..3233695) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3233704..3234204) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391549.2" /db_xref="EnsemblGenomes-Gn:BSU36680" /db_xref="EnsemblGenomes-Tr:CAB15685" /db_xref="GOA:P70963" /db_xref="SubtiList:BG12477" /db_xref="UniProtKB/Swiss-Prot:P70963" /translation="MHVRGNSMFGFNDMVKFLWSFLIVLPLVQIIHVSGHSFMAFIFG GKGSLDIGMGKTLLKIGPIRFRTIYFIDSFCRYGELKIDNRFSNALVYAGGCLFNLIT IFAINLLIIHSVLKPNVFFYQFVYFSTYYVFFALLPVRYSEKKSSDGLAIYKVLRYGE RYEIDK*" /label="ywmF CDS" gene complement(3233704..3234204) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /label="ywmF gene" promotor_-10 complement(3234240..3234259) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3234247) /Source="Nicolas_upshifts" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3234273..3234279) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3234339..3235472) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9843420, 10629174, 12875849, 19332814, 19684115" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9843420, 10629174, 12875849, 19332814, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391550.1" /db_xref="EnsemblGenomes-Gn:BSU36690" /db_xref="EnsemblGenomes-Tr:CAB15686" /db_xref="GOA:P70962" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11965" /db_xref="UniProtKB/Swiss-Prot:P70962" /translation="MAAYEIPSSQVGVKINKWYKHILAFQVADAVKLKEEIDLDIEQM EEDQLLLLYYQLISYRHQIMLDYVKPDLHEESQLQYRELIKTLESNQDSISGLSEYYF HLFRGMYEFEQNNYISAISFYRKAEKMLAFVEDEIERAEFHFKVAEVFYIMKQTHFSM NHAVQALETYKAHDFYRVRRIQCHFVISGNYIDYRNYEKALEHLDDAYRLALLEGQPR LIGSALYNIGNCYDDKGELDQAAEYFEKALPVFEDYQLEQLPKALFSLTRVLFKKQDS EAAIRYYEKGIAIAQKRNDFFSLAKYKFLQALYVESVNLNMIQEVFDYMEEKGLYVYI EEFALDAASYFSHREQYKEAVYFYEKAVSMREMIQRNDCLYEV*" /label="rapB CDS" gene complement(3234339..3235472) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /label="rapB gene" downshifts complement(3234357) /Source="Nicolas_upshifts" /id="D1901" /incds=0 /nref=244 /ntot=265 /MaxReadThrough="2.8683" /MaxDrop="6.81344" /score="30.5146793" /energy="-8.1" /TU="NA" /idTUdmin="U2883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(3235499..3235518) /Source="Nicolas_upshift_promotors" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3235506) /Source="Nicolas_upshifts" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3235569..3235587) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3235585) /Source="Nicolas_upshifts" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3235601..3235608) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3235664..3236689) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /EC_number="4.1.99.22" /function="16.10: Respire" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170340, 7860592, 16632608, 19566093, 23286307, 25896388, 25941396, 26575208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP 3',8-cyclase" /protein_id="NP_391551.1" /db_xref="EnsemblGenomes-Gn:BSU36700" /db_xref="EnsemblGenomes-Tr:CAB15687" /db_xref="GOA:P39757" /db_xref="InterPro:IPR000385" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010505" /db_xref="InterPro:IPR013483" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG10980" /db_xref="UniProtKB/Swiss-Prot:P39757" /translation="MITESRQMLDKRNRPLRDLRISVTDRCNFRCTYCMPAELFGPDY PFLKKEELLSFEELERLATLFVTRFGVEKIRLTGGEPLMRKDMPELIKKLARIPGIRD IAMTTNGSLLPVYAKRLKEAGLKRVTISLDSLEDERFKKINGRGVSVSKVLEGIEAAK QAGLGVKINMVVQKGVNEKDILPMARYFKEKGHILRFIEFMDVGNTNQWEKKDVMTKA EIIDLINKHMPVEPIAPNYIGEVASRFRYLDGSGEIGVISSVSDAFCGSCNRARLSAR GELFTCLFASSGFDLRAPVRQELSDDELSEMIGTVWKNRIDQYSVDRTLSKASGKKKV EMSYIGG*" /label="moaA CDS" gene complement(3235664..3236689) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /label="moaA gene" downshifts complement(3235677) /Source="Nicolas_upshifts" /id="D1902" /incds=0 /nref=23 /ntot=147 /MaxReadThrough="3.05546" /MaxDrop="3.66108" /score="13.625744" /energy="-10.8" /TU="NA" /idTUdmin="U2885" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3236705..3237493) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /function="16.11: Scavenge (Catabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2170340, 7860592, 19114526, 20011599, 22194618; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein sulfur transferase involved in molybdenum cofactor synthesis" /protein_id="NP_391552.1" /db_xref="EnsemblGenomes-Gn:BSU36710" /db_xref="EnsemblGenomes-Tr:CAB15688" /db_xref="GOA:P39756" /db_xref="InterPro:IPR003786" /db_xref="InterPro:IPR016193" /db_xref="SubtiList:BG10979" /db_xref="UniProtKB/Swiss-Prot:P39756" /translation="MNDKVTAVRDVWRYEQGEISKVEDRMVTEFPLTVILNGSEFVTL VCTPEHIEELVIGFLASEGVIRFQKEIKRFTIDESLGFVYVDLVHPETLDQKDYTKRV IGSCCGKGRHFYFQQDVKTAKTAVSQIKISPEACLALMKDMQQGSGTFQDTGGVHNAA LCDTEKLLLMRTDIGRHNALDKLYGHCLLNGMSVRDKLIVFSGRISSEVLLKAAKIGV SIVISKSAPTELAIQMAEELNITAIGFVRNGSFNVYTHPERIRE*" /label="fdhD CDS" gene complement(3236705..3237493) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /label="fdhD gene" promotor_-10 complement(3237519..3237538) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3237525) /Source="Nicolas_upshifts" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3237527..3237738) /Source="Nicolas_S_feature" /locus_tag="new_3774188_3774399_c" /HighExp="Etha, Sw, Salt, Heat, S8, Gly, S6, S7, BC, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16930300000000001" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1418" promotor_-35 complement(3237552..3237559) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3237739..3237900) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391553.1" /db_xref="EnsemblGenomes-Gn:BSU36720" /db_xref="EnsemblGenomes-Tr:CAB15689" /db_xref="GOA:P70966" /db_xref="SubtiList:BG12476" /db_xref="UniProtKB/Swiss-Prot:P70966" /translation="MKLFGMIFLIATVAFILLGVLLKLAAFFFVSILTLIAAIVLFTV LKKNQHNQT*" /label="ywmE CDS" gene complement(3237739..3237900) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /label="ywmE gene" promotor_-10 complement(3237913..3237931) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-10" upshifts complement(3237933) /Source="Nicolas_upshifts" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="upshifts" promotor_-35 complement(3237945..3237951) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-35" CDS complement(3237994..3238668) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391554.1" /db_xref="EnsemblGenomes-Gn:BSU36730" /db_xref="EnsemblGenomes-Tr:CAB15690" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12475" /db_xref="UniProtKB/Swiss-Prot:P70961" /translation="MKKLLAAGIIGLLTVSIASPSFAAEKQADTNVAVLFDGSGSMVQ KTGGERKIDIAKKSVKSFAELLPKDTNLMLRVFGHAGNNKLSGKALSCSTTETIYGLH PYEGSLFDNSLSELKPTGWTPIAKALADTRKEFEAFDADGKNVVYLITDGEETCGGDP AAEIEKLRASNVDTIVNIIGFNFDVKGNEEMKQAAVAGGGEYISANSADEFEQAWEKE AQKFTE*" /label="ywmD CDS" gene complement(3237994..3238668) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /label="ywmD gene" downshifts complement(3238009) /Source="Nicolas_upshifts" /id="D1903" /incds=0 /nref=16 /ntot=88 /MaxReadThrough="0.76221" /MaxDrop="4.19611" /score="25.2461653" /energy="-9.6" /TU="NA" /idTUdmin="U2886" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(3238721..3238861) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514009.1" /translation="MITQAVYAFWAEMAKNERHFKRFWTDRESSTKGSMSYIFLHFRI LA*" /label="hypothetical protein CDS" gene complement(3238721..3238861) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /label="gene" CDS complement(3238992..3239675) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391555.1" /db_xref="EnsemblGenomes-Gn:BSU36740" /db_xref="EnsemblGenomes-Tr:CAB15691" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12474" /db_xref="UniProtKB/Swiss-Prot:P70960" /translation="MKKRFSLIMMTGLLFGLTSPAFAAEKTETEAKAPANVAVLLDAS GSMAKRIDGVSKFNSAKKEISKFASSLPEGTQVKMSVFGSEGNNKNSGKVQSCEAIRN VYGFQSFNEQSFLNSLNTIGPTGWTPIAKALNEAKSSFDQLDAKGEKVVYLLTDGEET CGGNPIKTAKELQKDNITVNVIGFDYKEGYKGQLNAIAKVGGGEYFPAYTQKDVEKIF TQQSLMLSK*" /label="ywmC CDS" gene complement(3238992..3239675) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /label="ywmC gene" promotor_-35 3240052..3240056 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3240061..3241092) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15752199, 16959571, 17376078, 27226615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15752199, 16959571, 17376078, 27226615; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="lytic transglycosylase; autolysin required for complete dissolution of the asymmetric septum (stage II sporulation)" /protein_id="NP_391556.1" /db_xref="EnsemblGenomes-Gn:BSU36750" /db_xref="EnsemblGenomes-Tr:CAB15692" /db_xref="GOA:P07372" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="InterPro:IPR014225" /db_xref="SubtiList:BG10766" /db_xref="UniProtKB/Swiss-Prot:P07372" /translation="MKQFAITLSVLCALILLVPTLLVIPFQHNKEAGASVESEKTAVS TKPASKGAETLKASPVSIPVYRTANQSVENIPLEEYVIGVVASEMPATFKPEALKAQA LAARTFIVRLMVSNSAVEAPKGSLVDDTQMFQVYKSKAELKKQWGTSYETKLKKITDA VASTQGKILTYNNQPIEASFFSTSNGYTENAEAYWTSAIPYLKSVKSPWDKKSPKYKA TKTFTAAEFQQKLGVKLDGSSAVGKITGETPGHQVATAVINGKTLKGRDIREKLGLNS ADFEWKRNGDTITVTTRGFGHGVGMSQYGANFMAKEGKTVDDIVKYYYQGTQISEADA FLNKYMAKK*" /label="spoIID CDS" gene complement(3240061..3241092) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /label="spoIID gene" promotor_-10 3240071..3240090 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3240077) /Source="Nicolas_upshifts" /id="D1904" /incds=0 /nref=56 /ntot=156 /MaxReadThrough="0.87893" /MaxDrop="6.31542" /score="12.1351765" /energy="-8.7" /TU="NA" /idTUdmin="U2888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 3240089 /Source="Nicolas_upshifts" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3241120..3241138) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3241133) /Source="Nicolas_upshifts" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3241135..3241252) /Source="Nicolas_S_feature" /locus_tag="new_3777796_3777913_c" /HighExp="S8, M40t90, M9-stat, B36, LBGtran, G180, H2O2, M0t90, BT, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigI, SigWXY, SigA" /TUshortPSig="0.947, 0.999, 1, 0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1419" promotor_-35 complement(3241154..3241159) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3241194..3241199 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3241211..3243871 /Source="Nicolas_S_feature" /locus_tag="new_3777872_3780532" /HighExp="S8, S6, S7, S4, S3, C30, S5, T5.0H, T3.30H, BT" /AntisenseName="murAA" /AntisenseCor="5.8371061376981899E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.971" /TUlongSig="NA" /TUlongPSig="NA" /label="S1420" upshifts 3241211 /Source="Nicolas_upshifts" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3241215..3241233 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3241288..3242598) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /EC_number="2.5.1.7" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 14763982, 17714441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14763982, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391557.1" /db_xref="EnsemblGenomes-Gn:BSU36760" /db_xref="EnsemblGenomes-Tr:CAB15693" /db_xref="GOA:P70965" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG11955" /db_xref="UniProtKB/Swiss-Prot:P70965" /translation="MEKIIVRGGQKLNGTVKVEGAKNAVLPVIAASLLASEEKSVICD VPTLSDVYTINEVLRHLGADVHFENNEVTVNASYALQTEAPFEYVRKMRASVLVMGPL LARTGHARVALPGGCAIGSRPIDQHLKGFEAMGAEIKVGNGFIEAEVKGRLQGAKIYL DFPSVGATENLIMAAALAEGTTTLENVAKEPEIVDLANYINGMGGKIRGAGTGTIKIE GVEKLHGVKHHIIPDRIEAGTFMVAAAITEGNVLVKGAVPEHLTSLIAKMEEMGVTIK DEGEGLRVIGPKELKPIDIKTMPHPGFPTDMQSQMMALLLRASGTSMITETVFENRFM HAEEFRRMNGDIKIEGRSVIINGPVQLQGAEVAATDLRAGAALILAGLVAEGHTRVTE LKHLDRGYVDFHQKLAALGADIERVNDESASEQENKEVVSDLNA*" /label="murAA CDS" gene complement(3241288..3242598) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /label="murAA gene" downshifts complement(3241297) /Source="Nicolas_upshifts" /id="D1905" /incds=0 /nref=171 /ntot=256 /MaxReadThrough="5.3301" /MaxDrop="5.5423" /score="31.3825723" /energy="-11.8" /TU="U2890,U2891,U2892,U2894" /idTUdmin="U2890" /TUdmin="-98" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3242622..3242641) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3242629) /Source="Nicolas_upshifts" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3242632..3243372) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391558.1" /db_xref="EnsemblGenomes-Gn:BSU36770" /db_xref="EnsemblGenomes-Tr:CAB15694" /db_xref="InterPro:IPR014794" /db_xref="InterPro:IPR036209" /db_xref="PDB:2FPN" /db_xref="SubtiList:BG12473" /db_xref="UniProtKB/Swiss-Prot:O32277" /translation="MKKKQVSHAIIISVMLSFVIAVFHTIHASELTPLAQMAEGMERQ DVSIDKWTLHAKQNLSLTEKEFYQKVQRLKQEYRQYDWVIAREDKMIKAIGTYTDKKN RTSFRLQLVTTLKKHNPTSYLLYEQMSLETPDSWNDTYEQFERETLGIFQEKVVIFTC LNGHLDDNMNIVLQKKANQLLNEFQARSVEHVVEPNFVSISAFTDEWEEYIMTSKHKM NLQIALRSAGMGGKHTVTVGTPIVTTEY*" /label="ywmB CDS" gene complement(3242632..3243372) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /label="ywmB gene" promotor_-35 complement(3242655..3242664) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3243003) /Source="Nicolas_upshifts" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3243005..3243013) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3243027..3243035) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3243127..3243142) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3243135) /Source="Nicolas_upshifts" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3243155..3243164) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3243373..3243500) /Source="Nicolas_S_feature" /locus_tag="new_3780034_3780161_c" /HighExp="UNK1, S2, Lbexp, MG 60, MG 15, M9-tran, M/G, G135, MG 5, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1421" CDS complement(3243501..3243731) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391559.1" /db_xref="EnsemblGenomes-Gn:BSU36780" /db_xref="EnsemblGenomes-Tr:CAB15695" /db_xref="GOA:O32278" /db_xref="InterPro:IPR009526" /db_xref="SubtiList:BG14163" /db_xref="UniProtKB/Swiss-Prot:O32278" /translation="MSVLGQQAAIGIVVHLIFIAVTWWALQAVNIDPLIKKGKVVQAR LLMILLTIAIGTAVANFFLDYLNYSQQLPYLF*" /label="ywzB CDS" gene complement(3243501..3243731) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /label="ywzB gene" S_feature complement(3243732..3243994) /Source="Nicolas_S_feature" /locus_tag="new_3780393_3780655_c" /HighExp="UNK1, S2, Lbexp, MG 5, M9-tran, M/G, MG 15, MG 60, GM 15, MG t5" /AntisenseName="ywmA" /AntisenseCor="-0.24099136307237601" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1422" misc_feature 3243867..3243886 /Source="Nicolas_upshift_promotors" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3243873 /Source="Nicolas_upshifts" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="upshifts" CDS 3243901..3244374 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391560.1" /db_xref="EnsemblGenomes-Gn:BSU36790" /db_xref="EnsemblGenomes-Tr:CAB15696" /db_xref="SubtiList:BG12472" /db_xref="UniProtKB/Swiss-Prot:P70958" /translation="MNHSFFQPEKQYGEDLPIFDQEWEAIAFYYDYRQSQIEELNELC QFFNISLTYTRESLEELENLYFQSIQELLLADWNLPIEEFEKMISVYLIDCVIARHED AEWVVKPYPYKDGAYTLGFRRHRKSWHTMNACDGLYLRPKEDRPLLSLFDSLVRS*" /label="ywmA CDS" gene 3243901..3244374 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /label="ywmA gene" promotor_-10 complement(3243978..3243997) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-10" upshifts complement(3243994) /Source="Nicolas_upshifts" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="upshifts" S_feature complement(3243996..3244379) /Source="Nicolas_S_feature" /locus_tag="new_3780657_3781040_c" /HighExp="G135, G180, G150, H2O2, Oxctl, Paraq, Cold, M9-stat, C30, S0" /AntisenseName="ywmA" /AntisenseCor="-1.9581968147303098E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1423" promotor_-35 complement(3244012..3244015) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-35" CDS complement(3244408..3244806) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /EC_number="3.6.3.14" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8021203, 12837747, 15347741, 22720735, 23967352" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 12837747, 15347741, 22720735, 23967352; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit epsilon, F1 subunit)" /protein_id="NP_391561.1" /db_xref="EnsemblGenomes-Gn:BSU36800" /db_xref="EnsemblGenomes-Tr:CAB15697" /db_xref="GOA:P37812" /db_xref="InterPro:IPR001469" /db_xref="InterPro:IPR020546" /db_xref="InterPro:IPR020547" /db_xref="InterPro:IPR036771" /db_xref="InterPro:IPR036794" /db_xref="SubtiList:BG10822" /db_xref="UniProtKB/Swiss-Prot:P37812" /translation="MKTVKVNIVTPDGPVYDADIEMVSVRAESGDLGILPGHIPTVAP LKIGAVRLKKDGQTEMVAVSGGFVEVRPDHVTILAQAAETAEGIDKERAEAARQRAQE RLNSQSDDTDIRRAELALQRALNRLDVAGK*" /label="atpC CDS" gene complement(3244408..3244806) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /label="atpC gene" downshifts complement(3244424) /Source="Nicolas_upshifts" /id="D1906" /incds=0 /nref=283 /ntot=320 /MaxReadThrough="4.15968" /MaxDrop="7.84101" /score="22.7623678" /energy="-10.8" /TU="U2897,U2899" /idTUdmin="U2895" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3244798..3244816) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3244807) /Source="Nicolas_upshifts" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3244830..3244836) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3244830..3246251) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit beta, component F1)" /protein_id="NP_391562.1" /db_xref="EnsemblGenomes-Gn:BSU36810" /db_xref="EnsemblGenomes-Tr:CAB15698" /db_xref="GOA:P37809" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005722" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR024034" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10821" /db_xref="UniProtKB/Swiss-Prot:P37809" /translation="MKKGRVSQVLGPVVDVRFEDGHLPEIYNAIKISQPAASENEVGI DLTLEVALHLGDDTVRTIAMASTDGVQRGMEAVDTGAPISVPVGDVTLGRVFNVLGEN IDLNEPVPADAKKDPIHRQAPSFDQLSTEVEILETGIKVVDLLAPYIKGGKIGLFGGA GVGKTVLIQELINNIAQEHGGISVFAGVGERTREGNDLFYEMSDSGVINKTAMVFGQM NEPPGARMRVALTGLTMAEHFRDVQGQDVLFFIDNIFRFTQAGSEVSALLGRMPSAVG YQPTLATEMGQLQERITSTNVGSVTSIQAIYVPADDYTDPAPATTFAHLDATTNLERK LTEMGIYPAVDPLASTSRALAPEIVGEEHYAVAREVQSTLQRYKELQDIIAILGMDEL GEEDKLVVHRARRIQFFLSQNFHVAEQFTGQKGSYVPVKETVQGFKEILAGKYDHLPE DAFRLVGRIEEVVEKAKEMGVEV*" /label="atpD CDS" gene complement(3244830..3246251) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /label="atpD gene" CDS complement(3246277..3247140) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit gamma, component F1)" /protein_id="NP_391563.1" /db_xref="EnsemblGenomes-Gn:BSU36820" /db_xref="EnsemblGenomes-Tr:CAB15699" /db_xref="GOA:P37810" /db_xref="InterPro:IPR000131" /db_xref="InterPro:IPR023632" /db_xref="InterPro:IPR035968" /db_xref="SubtiList:BG10820" /db_xref="UniProtKB/Swiss-Prot:P37810" /translation="MASLRDIKSRITSTKKTSQITKAMQMVSAAKLNRAENNAKSFVP YMDKIQEVVSNVGRVSGNVKHPMLLSREVKKTAYLVITSDRGLAGAFNSSVLRSAYQA MQERHQSKDEYAVIAIGRVGRDFFKKREIPIISELTGLGDEVTFTEIKDLARQTIQMF IDGAFDELHLVYNHFVSAITQEVTEKKLLPLSDLGSGGGKRTASYEFEPSEEEVLEVL LPQYAESLIFGALLDSKASEHAARMTAMKNATDNAKELIDSLSLSYNRARQAAITQEI TEIVGGAAALE*" /label="atpG CDS" gene complement(3246277..3247140) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /label="atpG gene" S_feature complement(3247141..3247216) /Source="Nicolas_S_feature" /locus_tag="new_3783802_3783877_c" /HighExp="S0, S2, MG-0.2, MG-0.1, Mal, G150, BI, M0t45, G180, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1424" CDS complement(3247217..3248725) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit alpha, component F1)" /protein_id="NP_391564.1" /db_xref="EnsemblGenomes-Gn:BSU36830" /db_xref="EnsemblGenomes-Tr:CAB15700" /db_xref="GOA:P37808" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000793" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005294" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033732" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10819" /db_xref="UniProtKB/Swiss-Prot:P37808" /translation="MSIKAEEISTLIKQQIQNYQSDIEVQDVGTVIQVGDGIARVHGL DNCMAGELVEFSNGVLGMAQNLEESNVGIVILGPFSEIREGDEVKRTGRIMEVPVGEE LIGRIVNPLGQPVDGLGPILTSKTRPIESPAPGVMDRKSVHEPLQTGIKAIDALIPIG RGQRELIIGDRQTGKTSVAIDAILNQKDQDMICVYVAIGQKESTVRGVVETLRKHGAL DYTIVVTASASQPAPLLYLAPYAGVTMAEEFMYNGKHVLVVYDDLSKQAAAYRELSLL LRRPPGREAFPGDVFYLHSRLLERAAKLSDAKGAGSITALPFVETQAGDISAYIPTNV ISITDGQIFLQSDLFFSGVRPAINAGLSVSRVGGSAQIKAMKKVSGTLRLDLASYREL EAFAQFGSDLDQATQAKLNRGARTVEVLKQDLNKPLPVEKQVAILYALTKGYLDDIPV ADIRRFEEEYYMYLDQNHKDLLDGIAKTGNLPADEDFKAAIEGFKRTFAPSN*" /label="atpA CDS" gene complement(3247217..3248725) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /label="atpA gene" CDS complement(3248742..3249287) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit delta, component F1)" /protein_id="NP_391565.1" /db_xref="EnsemblGenomes-Gn:BSU36840" /db_xref="EnsemblGenomes-Tr:CAB15701" /db_xref="GOA:P37811" /db_xref="InterPro:IPR000711" /db_xref="InterPro:IPR020781" /db_xref="InterPro:IPR026015" /db_xref="SubtiList:BG10818" /db_xref="UniProtKB/Swiss-Prot:P37811" /translation="MSGSAVSKRYASALFDIANESAQLNQVEEELIVVKQVFQNEKAL NDVLNHPKVPAAKKKELIQNAFGSLSQSVLNTIFLLIDRHRAAIVPELTDEFIKLANV ARQTEDAIVYSVKPLTDAEMLPLSQVFAKKAGVASLRIRNEVQTDLIGGIKVRIGNRI YDGSVSGKLQRIERQLAGENR*" /label="atpH CDS" gene complement(3248742..3249287) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /label="atpH gene" CDS complement(3249284..3249796) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit b, component F0)" /protein_id="NP_391566.1" /db_xref="EnsemblGenomes-Gn:BSU36850" /db_xref="EnsemblGenomes-Tr:CAB15702" /db_xref="GOA:P37814" /db_xref="InterPro:IPR002146" /db_xref="InterPro:IPR005864" /db_xref="InterPro:IPR028987" /db_xref="SubtiList:BG10817" /db_xref="UniProtKB/Swiss-Prot:P37814" /translation="MSQLPLELGLSFNGGDILFQLLAMLILLALLKKYALGPLLNIMK QREDHIAGEITSAEEKNKEAQQLIEEQRVLLKEARQESQTLIENAKKLGEKQKEEIIQ AARAESERLKEAARTEIVKEKEQAVSALREQVASLSVMIASKVIEKELDEQAQEKLIQ DYLKEVGESR*" /label="atpF CDS" gene complement(3249284..3249796) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /label="atpF gene" S_feature complement(3249797..3249958) /Source="Nicolas_S_feature" /locus_tag="new_3786458_3786619_c" /HighExp="S2, Lbstat, Mal, M40t90, M0t90, G150, MG-0.1, G135, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1425" CDS complement(3249959..3250171) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit c, component F0)" /protein_id="NP_391567.1" /db_xref="EnsemblGenomes-Gn:BSU36860" /db_xref="EnsemblGenomes-Tr:CAB15703" /db_xref="GOA:P37815" /db_xref="InterPro:IPR000454" /db_xref="InterPro:IPR002379" /db_xref="InterPro:IPR005953" /db_xref="InterPro:IPR020537" /db_xref="InterPro:IPR035921" /db_xref="SubtiList:BG10816" /db_xref="UniProtKB/Swiss-Prot:P37815" /translation="MNLIAAAIAIGLGALGAGIGNGLIVSRTVEGIARQPEAGKELRT LMFMGIALVEALPIIAVVIAFLAFFG*" /label="atpE CDS" gene complement(3249959..3250171) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /label="atpE gene" CDS complement(3250217..3250951) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit a, component F0)" /protein_id="NP_391568.1" /db_xref="EnsemblGenomes-Gn:BSU36870" /db_xref="EnsemblGenomes-Tr:CAB15704" /db_xref="GOA:P37813" /db_xref="InterPro:IPR000568" /db_xref="InterPro:IPR023011" /db_xref="InterPro:IPR035908" /db_xref="SubtiList:BG10815" /db_xref="UniProtKB/Swiss-Prot:P37813" /translation="MNHGYRTIEFLGLTFNLTNILMITVASVIVLLIAILTTRTLSIR PGKAQNFMEWIVDFVRNIIGSTMDLKTGANFLALGVTLLMYIFVSNMLGLPFSITIGH ELWWKSPTADPAITLTLAVMVVALTHYYGVKMKGLKEYSKDYLRPVPFMLPMKIIEEF ANTLTLGLRLYGNIFAGEILLGLLAGLATSHYSQSVALGLVGTIGAILPMLAWQAFSL FIGAIQAFIFTMLTMVYMSHKISHDH*" /label="atpB CDS" gene complement(3250217..3250951) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /label="atpB gene" promotor_no_box 3250765..3250865 /Source="Nicolas_upshift_promotors" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3250825 /Source="Nicolas_upshifts" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3250959..3251342) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /function="16.1: Circulate" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12917488, 15849754, 16850406, 23123906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12917488, 15849754, 16850406, 23123906; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit i)" /protein_id="NP_391569.1" /db_xref="EnsemblGenomes-Gn:BSU36880" /db_xref="EnsemblGenomes-Tr:CAB15705" /db_xref="GOA:P37816" /db_xref="InterPro:IPR005598" /db_xref="SubtiList:BG10814" /db_xref="UniProtKB/Swiss-Prot:P37816" /translation="MDDPKLTFSRQRKYLLFILAVYVLGYGLTAYKTVFLGLILGTVF SLFNFLLLVRRMNAFDRAVEKGKSIRSLGSAARWCNAILAVAVAYKNPEYFHMASTVI GLMTIYPVIMIDSFIQLKRSSMEER*" /label="atpI CDS" gene complement(3250959..3251342) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /label="atpI gene" misc_feature complement(3251031..3251049) /Source="Nicolas_upshift_promotors" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3251033) /Source="Nicolas_upshifts" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3251343..3251613) /Source="Nicolas_S_feature" /locus_tag="new_3788004_3788274_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, UNK1, B60, G135, G180, G150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.96" /label="S1426" promotor_-35 3251575..3251584 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3251584 /Source="Nicolas_upshifts" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3251589..3251608) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" promotor_-10 3251598..3251617 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3251613) /Source="Nicolas_upshifts" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3251615..3251736) /Source="Nicolas_S_feature" /locus_tag="new_3788276_3788397_c" /HighExp="Etha, G180, H2O2, G135, Oxctl, G150, LBGexp, dia15, B36, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.96" /label="S1427" promotor_-35 complement(3251621..3251628) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3251765..3252394) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /EC_number="2.4.2.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7798145, 15689504, 15716449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 15689504, 15716449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil phosphoribosyltransferase" /protein_id="NP_391570.1" /db_xref="EnsemblGenomes-Gn:BSU36890" /db_xref="EnsemblGenomes-Tr:CAB15706" /db_xref="GOA:P39149" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005765" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR034332" /db_xref="SubtiList:BG10945" /db_xref="UniProtKB/Swiss-Prot:P39149" /translation="MGKVYVFDHPLIQHKLTYIRNENTGTKDFRELVDEVATLMAFEI TRDLPLEEVDINTPVQAAKSKVISGKKLGVVPILRAGLGMVDGILKLIPAAKVGHVGL YRDPETLKPVEYYVKLPSDVEEREFIVVDPMLATGGSAVEAIHSLKKRGAKNIRFMCL VAAPEGVEELQKHHSDVDIYIAALDEKLNEKGYIVPGLGDAGDRMFGTK*" /label="upp CDS" gene complement(3251765..3252394) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /label="upp gene" downshifts complement(3251781) /Source="Nicolas_upshifts" /id="D1907" /incds=0 /nref=180 /ntot=252 /MaxReadThrough="5.83241" /MaxDrop="5.91252" /score="1.39547358" /energy="-7.3" /TU="U2900,U2901" /idTUdmin="U2900" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3252438..3252457) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" upshifts complement(3252461) /Source="Nicolas_upshifts" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" promotor_-35 complement(3252472..3252479) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3252529..3253776) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /EC_number="2.1.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine hydroxymethyltransferase" /protein_id="NP_391571.1" /db_xref="EnsemblGenomes-Gn:BSU36900" /db_xref="EnsemblGenomes-Tr:CAB15707" /db_xref="GOA:P39148" /db_xref="InterPro:IPR001085" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR019798" /db_xref="SubtiList:BG10944" /db_xref="UniProtKB/Swiss-Prot:P39148" /translation="MKHLPAQDEQVFNAIKNERERQQTKIELIASENFVSEAVMEAQG SVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRAKEIFGAEHVNVQPHSGAQANMAVY FTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYDDVREKAL AHKPKLIVAGASAYPRTIDFKKFREIADEVGAYFMVDMAHIAGLVAAGLHPNPVPYAD FVTTTTHKTLRGPRGGMILCREEFGKKIDKSIFPGIQGGPLMHVIAAKAVSFGEVLQD DFKTYAQNVISNAKRLAEALTKEGIQLVSGGTDNHLILVDLRSLGLTGKVAEHVLDEI GITSNKNAIPYDPEKPFVTSGIRLGTAAVTSRGFDGDALEEVGAIIALALKNHEDEGK LEEARQRVAALTDKFPLYKELDY*" /label="glyA CDS" gene complement(3252529..3253776) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /label="glyA gene" downshifts complement(3252552) /Source="Nicolas_upshifts" /id="D1908" /incds=0 /nref=183 /ntot=229 /MaxReadThrough="5.99283" /MaxDrop="6.62881" /score="22.1245386" /energy="-15.8" /TU="U2901" /idTUdmin="U2902" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3253818..3253837) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3253835) /Source="Nicolas_upshifts" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3253837..3253921) /Source="Nicolas_S_feature" /locus_tag="new_3790498_3790582_c" /HighExp="dia5, C90, dia15, Diami, Lbtran, LPhT, M40t45, H2O2, BI, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1428" promotor_-35 complement(3253852..3253857) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3253966) /Source="Nicolas_upshifts" /id="D1909" /incds=0 /nref=3 /ntot=12 /MaxReadThrough="7.23859" /MaxDrop="5.0386" /score="-3.86767322" /energy="-4.3" /TU="U2902,U2903" /idTUdmin="U2904" /TUdmin=1137 /isTUend="FALSE" /label="downshifts" CDS complement(3253983..3254525) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391572.1" /db_xref="EnsemblGenomes-Gn:BSU36910" /db_xref="EnsemblGenomes-Tr:CAB15708" /db_xref="InterPro:IPR006340" /db_xref="InterPro:IPR028345" /db_xref="SubtiList:BG10943" /db_xref="UniProtKB/Swiss-Prot:P39157" /translation="MNELKQTWKTMLSEFQDQAELKQDQLFVLGCSTSEVAGSRIGTS GSVDIAESIYSGLAELREKTGIHLAFQCCEHLNRALVVEAETAKLFRLPTVSAVPVPK AGGAMASYAFKQMKSPVLVETIQADAGIDIGDTFIGMHLKPVAVPVRVSQNSLGSAHV TLARTRPKLIGGVRAVYECE*" /label="ywlG CDS" gene complement(3253983..3254525) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /label="ywlG gene" CDS complement(3254538..3254987) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /EC_number="5.3.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15755726, 15995210, 18640127, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 15995210, 18640127, 19446032; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose 5-phosphate epimerase (promiscuous)" /protein_id="NP_391573.1" /db_xref="EnsemblGenomes-Gn:BSU36920" /db_xref="EnsemblGenomes-Tr:CAB15709" /db_xref="GOA:P39156" /db_xref="InterPro:IPR003500" /db_xref="InterPro:IPR004785" /db_xref="InterPro:IPR036569" /db_xref="SubtiList:BG10942" /db_xref="UniProtKB/Swiss-Prot:P39156" /translation="MKVAIASDHGGVHIRNEIKELMDELQIEYIDMGCDCGSGSVDYP DYAFPVAEKVVSGEVDRGILICGTGIGMSISANKVKGIRCALAHDTFSAKATREHNDT NILAMGERVIGPGLAREIAKIWLTTEFTGGRHQTRIGKISDYEEKNL*" /label="rpiB CDS" gene complement(3254538..3254987) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /label="rpiB gene" S_feature complement(3254988..3255087) /Source="Nicolas_S_feature" /locus_tag="new_3791649_3791748_c" /HighExp="Diami, dia5, C90, dia15, LPhT, M40t45, LBGtran, Lbtran, T-0.40H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.68276199999999998" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1429" promotor_-10 complement(3255079..3255098) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-10" upshifts complement(3255087) /Source="Nicolas_upshifts" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="upshifts" promotor_-35 complement(3255112..3255119) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-35" CDS complement(3255144..3255596) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /EC_number="3.9.1.2" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210, 22517742, 24825175, 25610436, 27524296" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210, 22517742, 24825175, 25610436, 27524296; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-arginine(tyrosine moonlighting) phosphatase (oxidative stress)" /protein_id="NP_391574.1" /db_xref="EnsemblGenomes-Gn:BSU36930" /db_xref="EnsemblGenomes-Tr:CAB15710" /db_xref="GOA:P39155" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1ZGG" /db_xref="PDB:4ETI" /db_xref="PDB:4ETN" /db_xref="PDB:4KK3" /db_xref="PDB:4KK4" /db_xref="SubtiList:BG10941" /db_xref="UniProtKB/Swiss-Prot:P39155" /translation="MDIIFVCTGNTCRSPMAEALFKSIAEREGLNVNVRSAGVFASPN GKATPHAVEALFEKHIALNHVSSPLTEELMESADLVLAMTHQHKQIIASQFGRYRDKV FTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLKKDRR*" /label="prpB CDS" gene complement(3255144..3255596) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /label="prpB gene" promotor_-10 complement(3255613..3255632) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-10" upshifts complement(3255631) /Source="Nicolas_upshifts" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="upshifts" promotor_-35 complement(3255647..3255650) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-35" CDS complement(3255672..3256229) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 25774656, 25794618, 26076491; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="manganese efflux pump" /protein_id="NP_391575.1" /db_xref="EnsemblGenomes-Gn:BSU36940" /db_xref="EnsemblGenomes-Tr:CAB15711" /db_xref="GOA:P39154" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR022929" /db_xref="SubtiList:BG10940" /db_xref="UniProtKB/Swiss-Prot:P39154" /translation="MSDLFIGELITLSIMAFALGMDAFSVGLGMGMVKLRKKQIFYIG FIIGLFHVIMPLAGMAAGNMLSGLLGVLAVYIGGALLFVLGVQMLMASFKQSEERFMS PAGPGLLLFAIGVSLDSFSVGLSLGIYGSHPLLTITLFGLFSMMLTWLGLLVGKQVQS WLGTYSEALGGIILIVFGLKLLLPI*" /label="mntP CDS" gene complement(3255672..3256229) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /label="mntP gene" promotor_-10 complement(3256256..3256274) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-10" upshifts complement(3256269) /Source="Nicolas_upshifts" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="upshifts" promotor_-35 complement(3256290..3256295) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-35" CDS complement(3256308..3257348) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; threonine-dependent ADP-forming ATPase" /protein_id="NP_391576.1" /db_xref="EnsemblGenomes-Gn:BSU36950" /db_xref="EnsemblGenomes-Tr:CAB15712" /db_xref="GOA:P39153" /db_xref="InterPro:IPR005145" /db_xref="InterPro:IPR006070" /db_xref="InterPro:IPR010923" /db_xref="InterPro:IPR017945" /db_xref="SubtiList:BG10939" /db_xref="UniProtKB/Swiss-Prot:P39153" /translation="MKTKRWFVDVTDELSTNDPQIAQAAALLRENEVVAFPTETVYGL GANAKNTDAVKKIYEAKGRPSDNPLIVHIADISQLEDLTGPAPEKAKTLMKRFWPGAL TLILPCKPDALSPRVTAGLETVAIRMPDHPLALALIRESGLPIAAPSANLSGKPSPTK AEHVAHDLDGRIAGIVDGGPTGIGVESTVLSCADDIPVLLRPGGITKEQIEAVIGPIH VDKGLSDQNEKPISPGMKYTHYAPTAPLAICEGSPERIQHLIQEYQQGGRRVGVLTTE EKAGVYSADYVKSCGRRAQLETVAAGLYDALRSFDENKVDFIIAESFPDTGVGLAIMN RLMKAAGGRVIR*" /label="tsaC CDS" gene complement(3256308..3257348) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /label="tsaC gene" downshifts complement(3256313) /Source="Nicolas_upshifts" /id="D1910" /incds=0 /nref=4 /ntot=166 /MaxReadThrough="2.08557" /MaxDrop="2.98653" /score="-6.24994287" /energy="-9.8" /TU="NA" /idTUdmin="U2905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3257349..3257413) /Source="Nicolas_S_feature" /locus_tag="new_3794010_3794074_c" /HighExp="dia15, Diami, C90, LBGstat, Heat, LBGtran, dia5, LBGexp, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1430" promotor_-10 complement(3257403..3257422) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3257413) /Source="Nicolas_upshifts" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3257415..3257504) /Source="Nicolas_S_feature" /locus_tag="new_3794076_3794165_c" /HighExp="S3, M9-stat, Etha, LoTm, T5.0H, S7, S8, S4, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1431" promotor_-35 complement(3257438..3257442) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3257505..3257948) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391577.1" /db_xref="EnsemblGenomes-Gn:BSU36960" /db_xref="EnsemblGenomes-Tr:CAB15713" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10938" /db_xref="UniProtKB/Swiss-Prot:P39152" /translation="MFYQLRVAREKDGDVLEAFLKQAKTSYEGVKEGFTQFLMLEDSE KNIAGCLGIEKISCDQGLLRSLVISDKLHQGHIVTLFQSMEVLCEKHQIKTVYLVANQ HSSADFLTAMGFERAESVPEELFSSDHFCESRQTEGAVLMKKASG*" /label="ywlB CDS" gene complement(3257505..3257948) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /label="ywlB gene" CDS complement(3258015..3258689) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15044948, 16824103, 18378688, 20802044, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15044948, 16824103, 18378688, 20802044, 22111992; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator signal of pro-sigma(E) spoIIGA endopeptidase (stage II sporulation)" /protein_id="NP_391578.1" /db_xref="EnsemblGenomes-Gn:BSU36970" /db_xref="EnsemblGenomes-Tr:CAB15714" /db_xref="GOA:P39151" /db_xref="InterPro:IPR014202" /db_xref="SubtiList:BG10937" /db_xref="UniProtKB/Swiss-Prot:P39151" /translation="MKKTVIICIYIFLLLSGALVGLAKEETAQKSENQPVVIPDQAIR LRILANSDSDQDQQLKRHIRDAVNKEITTWVKDITSIEEARRVIRSKLPEIKAIAKET MEKEGANQSISVDFDKISFPTKLYGNMVYPAGEYEAILITLGNGDGANWWCVLFPPLC FLDFSNGEAVKEQEDKEASKKQTEKVLEDVTAKAEKAKKEENEEKEDGTEVKFFLVEW ISDLFS*" /label="spoIIR CDS" gene complement(3258015..3258689) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /label="spoIIR gene" promotor_-10 complement(3258451..3258469) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3258458) /Source="Nicolas_upshifts" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3258484..3258490) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3258721..3258738) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3258722) /Source="Nicolas_upshifts" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3258754..3258759) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3258795 /Source="Nicolas_upshifts" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3258799..3258818 /Source="Nicolas_upshift_promotors" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3258830..3259192 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391579.1" /db_xref="EnsemblGenomes-Gn:BSU36980" /db_xref="EnsemblGenomes-Tr:CAB15715" /db_xref="GOA:P39150" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG10936" /db_xref="UniProtKB/Swiss-Prot:P39150" /translation="MKYNYTVLLSAFTMSVLYSVIYIHSFIIAALITMAFYFLFPYLI FALPLQIMMNKKPKRFSPLYLLYYLAAAFIANAIIFGMLQPSGQSLFQNTAFYLFAVL TALIYWIWDSVLLQKKEA*" /label="ywlA CDS" gene 3258830..3259192 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /label="ywlA gene" downshifts complement(3259205) /Source="Nicolas_upshifts" /id="D1911" /incds=0 /nref=27 /ntot=242 /MaxReadThrough="2.64328" /MaxDrop="5.72616" /score="26.8558862" /energy="-11.3" /TU="U2910" /idTUdmin="U2909" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3259209..3259496) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391580.1" /db_xref="EnsemblGenomes-Gn:BSU36990" /db_xref="EnsemblGenomes-Tr:CAB15716" /db_xref="GOA:P45874" /db_xref="InterPro:IPR035167" /db_xref="SubtiList:BG11317" /db_xref="UniProtKB/Swiss-Prot:P45874" /translation="MKKALTAGILLIAIESMIGTIFPQALSYEAIFGVASLVLVGLAI ITSGLAVSGSDQRANYHSETKEGRTSRMKMAAAFFVAAIPSILCYLLTILF*" /label="ywkF CDS" gene complement(3259209..3259496) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /label="ywkF gene" S_feature complement(3259497..3259555) /Source="Nicolas_S_feature" /locus_tag="new_3796158_3796216_c" /HighExp="S6, S8, S7, BT, G135, G180, Paraq, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1432" promotor_-10 complement(3259553..3259572) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3259556..3260422) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /EC_number="2.1.1.297" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 16364916, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine methylase of release factor 1 (and perhaps others) at a GGQ site" /protein_id="NP_391581.1" /db_xref="EnsemblGenomes-Gn:BSU37000" /db_xref="EnsemblGenomes-Tr:CAB15717" /db_xref="GOA:P45873" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004556" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR019874" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11316" /db_xref="UniProtKB/Swiss-Prot:P45873" /translation="MKTIFEALKWASSYLTEAGREENAAELLLLYDTGMERSKLLASL QEPIGEDELYRFKRHVEMHKEGVPVQYIIGKEFFYGREFMVNDDVLIPRPETEEVVFH LLEKYRSVFSEDGKLEVVDVGTGSGAIAVTLALENQSFSVSAVDISKEALQVASANAE KLGANVRFYQGDLLEPFIKAGKKADIIVSNPPYISEEEMADLSEIVRFHEPLHALTDG GDGLKFYKRFMEDIPLVMKDKVFVVFEIGWKQGAAVKDLILKAFKGAEVEVLKDINGK DRTICALIHKNK*" /label="prmC CDS" gene complement(3259556..3260422) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /label="prmC gene" upshifts complement(3259569) /Source="Nicolas_upshifts" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3259585..3259594) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3260424..3261494) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /experiment="publication(s) with functional evidences, PMID:2186375, 1408743, 10446248, 12237459, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2186375, 1408743, 10446248, 12237459, 12682299; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 1" /protein_id="NP_391582.1" /db_xref="EnsemblGenomes-Gn:BSU37010" /db_xref="EnsemblGenomes-Tr:CAB15718" /db_xref="GOA:P45872" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004373" /db_xref="InterPro:IPR005139" /db_xref="SubtiList:BG11244" /db_xref="UniProtKB/Swiss-Prot:P45872" /translation="MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQET VDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEEISELQKETETLSERLKVLLIPK DPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKE IIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEK DIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARI YDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRIGLTIQKLDQILEGK LDEVVEALIVEDQASKLQQSEG*" /label="prfA CDS" gene complement(3260424..3261494) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /label="prfA gene" downshifts complement(3260427) /Source="Nicolas_upshifts" /id="D1912" /incds=0 /nref=23 /ntot=212 /MaxReadThrough="5.17118" /MaxDrop="3.44681" /score="-9.55295942" /energy="-10.5" /TU="U2910" /idTUdmin="U2912" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" downshifts 3261495 /Source="Nicolas_upshifts" /id="D1913" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.13519" /MaxDrop="4.28706" /score="36.3991981" /energy="-10.4" /TU="NA" /idTUdmin="U2911" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3261522..3261541) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3261546) /Source="Nicolas_upshifts" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3261548..3261659) /Source="Nicolas_S_feature" /locus_tag="new_3798209_3798320_c" /HighExp="S6, S8, S7, BT, S5, Etha, B36, C30, S4, GM 25" /AntisenseName="ywkD" /AntisenseCor="-0.43140174721346802" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.927" /TUlongSig="NA" /TUlongPSig="NA" /label="S1433" promotor_-35 complement(3261555..3261561) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3261591..3261610 /Source="Nicolas_upshift_promotors" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3261605 /Source="Nicolas_upshifts" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3261620..3262006 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391583.1" /db_xref="EnsemblGenomes-Gn:BSU37020" /db_xref="EnsemblGenomes-Tr:CAB15719" /db_xref="GOA:P45871" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11315" /db_xref="UniProtKB/Swiss-Prot:P45871" /translation="MLLKSIHHIAIICSDYEKSKAFYVHKLGFQVIQETYREERGSYK LDLSLNGSYVIELFSFPDPPERQTRPEAAGLRHLAFTVGSLDKAVQELHEKGIETEPI RTDPLTGKRFTFFFDPDQLPLELYEQ*" /label="ywkD CDS" gene 3261620..3262006 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /label="ywkD gene" promotor_-10 complement(3261641..3261659) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-10" upshifts complement(3261659) /Source="Nicolas_upshifts" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="upshifts" promotor_-35 complement(3261673..3261680) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-35" promotor_-35 3262074..3262082 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3262093..3262111 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3262094 /Source="Nicolas_upshifts" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3262128..3262682 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15780934, 17139259, 19478798, 22720735, 27059541, 27085804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15780934, 17139259, 19478798, 22720735, 27059541, 27085804; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome-pole-anchoring protein RacA" /protein_id="NP_391584.1" /db_xref="EnsemblGenomes-Gn:BSU37030" /db_xref="EnsemblGenomes-Tr:CAB15720" /db_xref="GOA:P45870" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR023522" /db_xref="PDB:5I41" /db_xref="PDB:5I44" /db_xref="SubtiList:BG11314" /db_xref="UniProtKB/Swiss-Prot:P45870" /translation="MNTNMVASELGVSAKTVQRWVKQLNLPAERNELGHYSFTAEDVK VLKSVQKQISEGTAIQDIHLPKSAKKRTGFLVQKTSSDTERRIEQLEQKLDTLLQQRQ DESELMARMSELERQLKQKADEGVSYQLLQHRREIDDILADLQSLTSQMKEFTAHSIP ETAAASEKTKTRKKPLLSLFKFQT*" /label="racA CDS" gene 3262128..3262682 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /label="racA gene" misc_feature 3262612..3262616 /Source="Nicolas_upshift_promotors" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3262617 /Source="Nicolas_upshifts" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3262661 /Source="Nicolas_upshifts" /id="D1914" /incds=0 /nref=213 /ntot=274 /MaxReadThrough="0.82868" /MaxDrop="8.28021" /score="36.3991981" /energy="-10.4" /TU="U2913" /idTUdmin="U2914" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3262716..3263675) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12949160, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391585.1" /db_xref="EnsemblGenomes-Gn:BSU37040" /db_xref="EnsemblGenomes-Tr:CAB15721" /db_xref="GOA:P45869" /db_xref="InterPro:IPR004776" /db_xref="InterPro:IPR014024" /db_xref="SubtiList:BG11313" /db_xref="UniProtKB/Swiss-Prot:P45869" /translation="MSILDILILLAPIFFVIVLGWFAGHFGSYDAKSAKGVSTLVTKY ALPAHFIAGILTTSRSEFLSQVPLMISLIIGIVGFYIIILLVCRFIFKYDLTNSSVFS LNSAQPTFAFMGIPVLGSLFGANEVAIPIAVTGIVVNAILDPLAIIIATVGESSKKNE ESGDSFWKMTGKSILHGLCEPLAAAPLISMILVLVFNFTLPELGVKMLDQLGSTTSGV ALFAVGVTVGIRKIKLSMPAIGIALLKVAVQPALMFLIALAIGLPADQTTKAILLVAF PGSAVAAMIATRFEKQEEETATAFVVSAILSLISLPIIIALTA*" /label="ywkB CDS" gene complement(3262716..3263675) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /label="ywkB gene" downshifts complement(3262738) /Source="Nicolas_upshifts" /id="D1915" /incds=0 /nref=36 /ntot=74 /MaxReadThrough="2.86006" /MaxDrop="4.78642" /score="20.048754" /energy="-10.4" /TU="U2916" /idTUdmin="U2917" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3263713..3263731) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3263727) /Source="Nicolas_upshifts" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3263746..3263752) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3263757..3265505) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12949160, 16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949160, 16788182, 20933603, 22740702, 23136871, 24325460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_391586.1" /db_xref="EnsemblGenomes-Gn:BSU37050" /db_xref="EnsemblGenomes-Tr:CAB15722" /db_xref="GOA:P45868" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11312" /db_xref="UniProtKB/Swiss-Prot:P45868" /translation="MGYYLTWLTISRKKEICLNNIKKTKEGHLETTLRGKEVLSIPTL NKGVAFSLEERQELGLEGLLPPTVLSLDQQAQRAYEQFQAQPDRLRQNVYLSDLANRN EVLFYKLLKNHLREMLPVVYTPTVGEAIQEYSHEYRRPQGIYLSIDNIDGIEKAFENL HATAGDIDLIVATDSESILGIGDWGVGGINIAIGKLAVYTAAAGIDPSRVIPVVLDVG TNNEKLLNDPLYIGNKHERVQGERYEAFIDAYVKAALKFFPKALLHWEDLGNKNARNI MKKYNHEILTFNDDIQGTGAITLAGVLAAMKKTGASIKDQRVVIFGAGSAGIGIADQI RDTMVLAGLSEEEANKRFYTLDYRGLLTEDIEGILDFQKPYLRNADEVKDWKRDEKGQ IPFDEVVRQAKPTILIGTSGVSGAFTEEIVKEMASHVDRPVIMPMSNPTHLAEAVPED LFKWTDGKVLIATGSPFDNVEYNGVSYEIGQSNNAFAFPGLGLGSIVAEARIITPAMF AATADAIAEMVDLETPGAGLLPSIDKLQEVSIQVAIAVAEAAIKDGVANRQPEDVKQA VLDAMWTPEYKKVIAK*" /label="maeA CDS" gene complement(3263757..3265505) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /label="maeA gene" promotor_-10 complement(3264231..3264249) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3264239) /Source="Nicolas_upshifts" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3264264..3264270) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3265506..3265596) /Source="Nicolas_S_feature" /locus_tag="new_3802167_3802257_c" /HighExp="GM 25, GM 15, GM 60, GM 90, GM 120, MG-0.2, MG 15, GM 45, MG-0.1, GM 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1434" promotor_-10 complement(3265580..3265599) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3265596) /Source="Nicolas_upshifts" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3265613..3265620) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3265739) /Source="Nicolas_upshifts" /id="D1916" /incds=0 /nref=11 /ntot=126 /MaxReadThrough="2.81368" /MaxDrop="3.39095" /score="20.3711149" /energy="-7.5" /TU="NA" /idTUdmin="U2918" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(3265744..3266331) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /EC_number="2.7.1.21" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2423635, 17132103; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidine kinase" /protein_id="NP_391587.1" /db_xref="EnsemblGenomes-Gn:BSU37060" /db_xref="EnsemblGenomes-Tr:CAB15723" /db_xref="GOA:Q03221" /db_xref="InterPro:IPR001267" /db_xref="InterPro:IPR020633" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10419" /db_xref="UniProtKB/Swiss-Prot:Q03221" /translation="MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKP VIDNRYSEAAVVSHNGTSMTSYAISSAADIWDHISESTDVVAVDEVQFFDQEIVEVLS SLADKGYRVIAAGLDMDFRGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLID GKPASYDDPVILVGAAESYEARCRHHHEVPGKSKK*" /label="tdk CDS" gene complement(3265744..3266331) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /label="tdk gene" CDS complement(3266420..3266620) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_391588.1" /db_xref="EnsemblGenomes-Gn:BSU37070" /db_xref="EnsemblGenomes-Tr:CAB15724" /db_xref="GOA:Q03223" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027491" /db_xref="InterPro:IPR034704" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10417" /db_xref="UniProtKB/Swiss-Prot:Q03223" /translation="MKAGIHPNFKKATVKCACGNEFETGSVKEEVRVEICSECHPFYT GRQKFASADGRVDRFNKKYGLK*" /label="rpmEA CDS" gene complement(3266420..3266620) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /label="rpmEA gene" downshifts complement(3266433) /Source="Nicolas_upshifts" /id="D1917" /incds=0 /nref=268 /ntot=279 /MaxReadThrough="5.35148" /MaxDrop="6.82076" /score="15.63162" /energy="-10.3" /TU="U2918,U2919" /idTUdmin="U2921" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3266621..3266698) /Source="Nicolas_S_feature" /locus_tag="new_3803282_3803359_c" /HighExp="HPh, LPh, LPhT, GM 45, Paraq, MG 45, MG 60, aero, LBGexp, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1435" promotor_-10 complement(3266694..3266713) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3266698) /Source="Nicolas_upshifts" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3266727..3266734) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3266739..3268022) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10027981, 16014871, 18852477, 28520932, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10027981, 16014871, 18852477, 28520932, 28723971; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcriptional terminator Rho" /protein_id="NP_391589.2" /db_xref="EnsemblGenomes-Gn:BSU37080" /db_xref="EnsemblGenomes-Tr:CAB15725" /db_xref="GOA:Q03222" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004665" /db_xref="InterPro:IPR011112" /db_xref="InterPro:IPR011113" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036269" /db_xref="SubtiList:BG10416" /db_xref="UniProtKB/Swiss-Prot:Q03222" /translation="MKDVSISSLENMKLKELYELARHYKISYYSKLTKKELIFAILKA NAEQEDLLFMEGVLEIIQSEGFGFLRPINYSPSSEDIYISASQIRRFDLRNGDKVSGK VRPPKENERYYGLLHVEAVNGDDPESAKERVHFPALTPLYPDRQMVLETKPNFLSTRI MDMMAPVGFGQRGLIVAPPKAGKTMLLKEIANSITANQPEAELIVLLIDERPEEVTDI ERSVAGDVVSSTFDEVPENHIKVAELVLERAMRLVEHKKDVIILMDSITRLARAYNLV IPPSGRTLSGGIDPAAFHRPKRFFGAARNIEEGGSLTILATALVDTGSRMDDVIYEEF KGTGNMELHLDRSLAERRIFPAIDIRRSGTRKEELLVPKEHLDRLWSIRKTMSDSPDF AEKFMRKMKKTKTNQEFFDILNQEWKQANLSSARR*" /label="rho CDS" gene complement(3266739..3268022) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /label="rho gene" S_feature complement(3268023..3268325) /Source="Nicolas_S_feature" /locus_tag="new_3804684_3804986_c" /HighExp="H2O2, Cold, G135, HPh, G180, G150, LBGstat, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1436" CDS complement(3268053..3268214) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 20525796" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514010.1" /db_xref="EnsemblGenomes-Gn:BSU37089" /db_xref="EnsemblGenomes-Tr:CCQ48606" /db_xref="UniProtKB/TrEMBL:L8EA05" /translation="MFLSSLPSKLIKTILLTKAPIMGGSVTDRSSFMLKKECALADVV QKQQMTCSE*" /label="hypothetical protein CDS" gene complement(3268053..3268214) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /label="gene" promotor_-10 complement(3268305..3268324) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3268325) /Source="Nicolas_upshifts" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3268340..3268344) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3268429..3269394) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /EC_number="3.1.3.11" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose 1,6-bisphosphatase class II" /protein_id="NP_391590.1" /db_xref="EnsemblGenomes-Gn:BSU37090" /db_xref="EnsemblGenomes-Tr:CAB15726" /db_xref="GOA:Q03224" /db_xref="InterPro:IPR004464" /db_xref="SubtiList:BG10415" /db_xref="UniProtKB/Swiss-Prot:Q03224" /translation="MERSLSMELVRVTEAAALASARWMGRGKKDEADEAATSAMRDVF DTVPMKGTVVIGEGEMDEAPMLYIGEKLGNGYGPRVDVAVDPLEGTNILASGGWNALT VIAVADHGTLLNAPDMYMQKIAVGPEAVGCIDIEAPVIDNLKAVAKAKNKDVEDVVAT ILNRERHAKIISELREAGARIKLINDGDVAGAINTAFDHTGVDILFGSGGAPEGVLSA VALKALGGEIIGKLLPQSEEEITRCHKMGLDLSKVLRMEDLVKGDDAIFAATGVTDGE LLKGVQFKGSVGTTESLVIRAKSGTVRFVDGRHSLKKKPNLVIRP*" /label="glpX CDS" gene complement(3268429..3269394) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /label="glpX gene" downshifts complement(3268435) /Source="Nicolas_upshifts" /id="D1918" /incds=0 /nref=56 /ntot=196 /MaxReadThrough="5.42698" /MaxDrop="5.21817" /score="-2.15106481" /energy="-10.2" /TU="U2921,U2922" /idTUdmin="U2922" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 3269011..3269020 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3269033..3269052 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3269041 /Source="Nicolas_upshifts" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3269425..3270714) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /EC_number="2.5.1.7" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14763982, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14763982, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391591.2" /db_xref="EnsemblGenomes-Gn:BSU37100" /db_xref="EnsemblGenomes-Tr:CAB15727" /db_xref="GOA:P19670" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10414" /db_xref="UniProtKB/Swiss-Prot:P19670" /translation="MEKLNIAGGDSLNGTVHISGAKNSAVALIPATILANSEVTIEGL PEISDIETLRDLLKEIGGNVHFENGEMVVDPTSMISMPLPNGKVKKLRASYYLMGAML GRFKQAVIGLPGGCHLGPRPIDQHIKGFEALGAEVTNEQGAIYLRAERLRGARIYLDV VSVGATINIMLAAVLAEGKTIIENAAKEPEIIDVATLLTSMGAKIKGAGTNVIRIDGV KELHGCKHTIIPDRIEAGTFMIAGAAMGKEVIIDNVIPTHLESLTAKLREMGYHIETS DDQLLIVGGQKNLKPVDVKTLVYPGFPTDLQQPMTALLTRAKGTSVVTDTIYSARFKH IDELRRMGANMKVEGRSAIITGPVELQGAKVKASDLRAGACLVVAGLMADGVTEITGL EHIDRGYSSLEKKLEGLGATIWRERMTDEEIEQLQNS*" /label="murAB CDS" gene complement(3269425..3270714) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /label="murAB gene" S_feature complement(3270715..3271074) /Source="Nicolas_S_feature" /locus_tag="new_3807376_3807735_c" /HighExp="dia5, Fru, UNK1, Glucon, HiOs, T-5.40H, nit, SMM, MG 120, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16076699999999999" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1437" CDS complement(3271093..3271731) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /EC_number="2.2.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 12469342, 22212631, 23468065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 12469342, 22212631, 23468065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transaldolase" /protein_id="NP_391592.3" /db_xref="EnsemblGenomes-Gn:BSU37110" /db_xref="EnsemblGenomes-Tr:CAB15728" /db_xref="GOA:P19669" /db_xref="InterPro:IPR001585" /db_xref="InterPro:IPR004731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018225" /db_xref="InterPro:IPR022999" /db_xref="InterPro:IPR033919" /db_xref="PDB:3R8R" /db_xref="SubtiList:BG10413" /db_xref="UniProtKB/Swiss-Prot:P19669" /translation="MLFFVDTANIDEIREANELGILAGVTTNPSLVAKEANVSFHDRL REITDVVKGSVSAEVISLKAEEMIEEGKELAKIAPNITVKIPMTSDGLKAVRALTDLG IKTNVTLIFNANQALLAARAGATYVSPFLGRLDDIGHNGLDLISEVKQIFDIHGLDTQ IIAASIRHPQHVTEAALRGAHIGTMPLKVIHALTKHPLTDKGIEQFLADWNK*" /label="tal CDS" gene complement(3271093..3271731) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /label="tal gene" downshifts complement(3271119) /Source="Nicolas_upshifts" /id="D1919" /incds=0 /nref=6 /ntot=65 /MaxReadThrough="6.97243" /MaxDrop="4.038" /score="-6.93331064" /energy="-18.4" /TU="U2921,U2922" /idTUdmin="U2926" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" S_feature complement(3271732..3271850) /Source="Nicolas_S_feature" /locus_tag="new_3808393_3808511_c" /HighExp="dia5, LBGtran, M40t45, Lbtran, Mt0, M40t90, M0t45, Lbstat, Lbexp, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1438" CDS complement(3271851..3272708) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /EC_number="4.1.2.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphate aldolase" /protein_id="NP_391593.1" /db_xref="EnsemblGenomes-Gn:BSU37120" /db_xref="EnsemblGenomes-Tr:CAB15729" /db_xref="GOA:P13243" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10412" /db_xref="UniProtKB/Swiss-Prot:P13243" /translation="MPLVSMTEMLNTAKEKGYAVGQFNLNNLEFTQAILQAAEEEKSP VILGVSEGAGRYMGGFKTVVAMVKALMEEYKVTVPVAIHLDHGSSFESCAKAIHAGFT SVMIDASHHPFEENVATTAKVVELAHFHGVSVEAELGTVGGQEDDVIAEGVIYADPKE CQELVERTGIDCLAPALGSVHGPYKGEPNLGFKEMEEIGKSTGLPLVLHGGTGIPTAD IKKSISLGTAKINVNTENQISSAKAVRETLAAKPDEYDPRKYLGPAREAIKETVIGKM REFGSSNQA*" /label="fbaA CDS" gene complement(3271851..3272708) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /label="fbaA gene" S_feature complement(3272709..3272835) /Source="Nicolas_S_feature" /locus_tag="new_3809370_3809496_c" /HighExp="C90, Lbtran, LBGtran, dia5, LBGexp, aero, M0t90, Glu, Lbexp, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1439" promotor_-10 complement(3272817..3272836) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-10" upshifts complement(3272835) /Source="Nicolas_upshifts" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="upshifts" promotor_-35 complement(3272850..3272857) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-35" CDS complement(3272889..3273263) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator of sporulation initiation" /protein_id="NP_391594.1" /db_xref="EnsemblGenomes-Gn:BSU37130" /db_xref="EnsemblGenomes-Tr:CAB15730" /db_xref="GOA:P06628" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="PDB:1F51" /db_xref="PDB:1FSP" /db_xref="PDB:1NAT" /db_xref="PDB:1PEY" /db_xref="PDB:1PUX" /db_xref="PDB:1SRR" /db_xref="PDB:2FSP" /db_xref="PDB:2FTK" /db_xref="PDB:2JVI" /db_xref="PDB:2JVJ" /db_xref="PDB:2JVK" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG10411" /db_xref="UniProtKB/Swiss-Prot:P06628" /translation="MMNEKILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVT KERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYGELDMIQESKELGALTHF AKPFDIDEIRDAVKKYLPLKSN*" /label="spo0F CDS" gene complement(3272889..3273263) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /label="spo0F gene" promotor_-10 complement(3273303..3273321) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3273317) /Source="Nicolas_upshifts" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="upshifts" S_feature complement(3273319..3273958) /Source="Nicolas_S_feature" /locus_tag="new_3809980_3810619_c" /HighExp="dia15, Diami, dia5, G135, Etha, G150, G180, Salt, H2O2, Paraq" /AntisenseName="ywjG" /AntisenseCor="0.58536525532649697" /AntisenseRegPval="-25.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1440" promotor_-35 3273320..3273323 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3273332..3273340) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" promotor_-10 3273339..3273358 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3273352 /Source="Nicolas_upshifts" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3273366..3273371 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3273387..3273406 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3273397 /Source="Nicolas_upshifts" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" CDS 3273429..3273950 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391595.1" /db_xref="EnsemblGenomes-Gn:BSU37140" /db_xref="EnsemblGenomes-Tr:CAB15731" /db_xref="InterPro:IPR019676" /db_xref="SubtiList:BG11053" /db_xref="UniProtKB/Swiss-Prot:P06629" /translation="MLKIFTTQLTGIFSRIQDKESDAIEDGARLLAQAVISGHSIYLY GANELQGVFYEATESKEPFPSVKAFPENAEEVTESDRVLMFCSGTGTAEEQELAKELY EKGAGVVCVSPAAKDSAGIEQYCDVHIDSKLKMPLVPDEDGTRYGFPSLMTALYVYHA LSFTLKEILQEYA*" /label="ywjG CDS" gene 3273429..3273950 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /label="ywjG gene" promotor_-35 3273893..3273896 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3273911..3273930 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3273925 /Source="Nicolas_upshifts" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3273948..3273967) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3273958) /Source="Nicolas_upshifts" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="upshifts" downshifts 3273969 /Source="Nicolas_upshifts" /id="D1920" /incds=0 /nref=191 /ntot=242 /MaxReadThrough="1.98527" /MaxDrop="5.8354" /score="11.5531593" /energy="-11.9" /TU="NA" /idTUdmin="U2923" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3273982..3273989) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" CDS complement(3274032..3275639) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /EC_number="6.3.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11544212, 15252202, 17158658, 17302819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544212, 15252202, 17158658, 17302819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CTP synthetase" /protein_id="NP_391596.1" /db_xref="EnsemblGenomes-Gn:BSU37150" /db_xref="EnsemblGenomes-Tr:CAB15743" /db_xref="GOA:P13242" /db_xref="InterPro:IPR004468" /db_xref="InterPro:IPR017456" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033828" /db_xref="SubtiList:BG10410" /db_xref="UniProtKB/Swiss-Prot:P13242" /translation="MTKYIFVTGGVVSSLGKGIVAASLGRLLKNRGLNVTIQKFDPYI NVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKFSNVTTGKIYSTVLKKE RRGDYLGGTVQVIPHITNELKDRVYRAGKETNADVVITEIGGTVGDIESLPFLEAIRQ MKSDIGRENVMYIHCTLVPYIKAAGELKTKPTQHSVKELRSLGIQPNIIVVRTEMPIS QDMKDKIALFCDIDTKAVIECEDADNLYSIPLELQKQGLDKLVCEHMKLACKEAEMSE WKELVNKVSNLSQTITIGLVGKYVELPDAYISVVESLRHAGYAFDTDVKVKWINAEEV TENNIAELTSGTDGIIVPGGFGDRGVEGKIVATKYARENNIPFLGICLGMQVASIEYA RNVLGLKGAHSAEIDPSTQYPIIDLLPEQKDVEDLGGTLRLGLYPCKLEEGTKAFEVY QDEVVYERHRHRYEFNNEFRQQMEEQGFVFSGTSPDGRLVEIIELKDHPWFVASQFHP EFKSRPTRPQPLFKGFIGASVEAANQK*" /label="pyrG CDS" gene complement(3274032..3275639) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /label="pyrG gene" downshifts complement(3274045) /Source="Nicolas_upshifts" /id="D1921" /incds=0 /nref=222 /ntot=259 /MaxReadThrough="2.2929" /MaxDrop="8.17874" /score="18.9699606" /energy="-12.1" /TU="NA" /idTUdmin="U2927" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3275640..3275827) /Source="Nicolas_S_feature" /locus_tag="new_3812301_3812488_c" /HighExp="LBGexp, Lbexp, dia0, G150, G135, G180, Paraq, Oxctl, dia15, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1441" promotor_-10 complement(3275815..3275834) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3275827) /Source="Nicolas_upshifts" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3275849..3275856) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3275881..3276402) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase (delta subunit) and transcriptional repressor" /protein_id="NP_391597.1" /db_xref="EnsemblGenomes-Gn:BSU37160" /db_xref="EnsemblGenomes-Tr:CAB15744" /db_xref="GOA:P12464" /db_xref="InterPro:IPR007759" /db_xref="InterPro:IPR029757" /db_xref="PDB:2KRC" /db_xref="PDB:2M4K" /db_xref="PDB:4NC7" /db_xref="PDB:4NC8" /db_xref="SubtiList:BG10409" /db_xref="UniProtKB/Swiss-Prot:P12464" /translation="MGIKQYSQEELKEMALVEIAHELFEEHKKPVPFQELLNEIASLL GVKKEELGDRIAQFYTDLNIDGRFLALSDQTWGLRSWYPYDQLDEETQPTVKAKKKKA KKAVEEDLDLDEFEEIDEDDLDLDEVEEELDLEADDFDEEDLDEDDDDLEIEEDIIDE DDEDYDDEEEEIK*" /label="rpoE CDS" gene complement(3275881..3276402) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /label="rpoE gene" downshifts complement(3275937) /Source="Nicolas_upshifts" /id="D1922" /incds=0 /nref=7 /ntot=182 /MaxReadThrough="6.49215" /MaxDrop="3.2129" /score="19.8764263" /energy="-19.4" /TU="U2928,U2929" /idTUdmin="U2927" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" S_feature complement(3276403..3276505) /Source="Nicolas_S_feature" /locus_tag="new_3813064_3813166_c" /HighExp="H2O2, Paraq, Oxctl, LBGexp, G180, dia15, dia0, Lbexp, BMM, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1442" promotor_-10 complement(3276486..3276505) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3276505) /Source="Nicolas_upshifts" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3276507..3276584) /Source="Nicolas_S_feature" /locus_tag="new_3813168_3813245_c" /HighExp="T0.30H, S8, S7, S6, S4, S3, S5, Sw, BC, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1443" promotor_-35 complement(3276521..3276524) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3276585..3277724) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase" /protein_id="NP_391598.1" /db_xref="EnsemblGenomes-Gn:BSU37170" /db_xref="EnsemblGenomes-Tr:CAB15745" /db_xref="GOA:P45867" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG11239" /db_xref="UniProtKB/Swiss-Prot:P45867" /translation="MNFSLSEEHEMIRKLVRDFAKHEVAPTAAERDEQERFDRELFRE MANLGLTGIPWPEDYGGIGSDYLAYVIAVEELSKVCASTGVTLSAHISLCSWPLFAFG TEEQKTEYLTQLALGEKIGAFALTEAGSGSDAGSMKTTAERIGDDYVLNGSKVFITNG GVADIYIVFAVTDPEKKKKGVTAFIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCV VPASKRLGEEGEGFKIAMKTLDGGRNGIAAQAVGIAQGALDAALQYAKERKQFGKSIA EQQGIAFKLADMATMIEASRLLTYQAAWLESSGLPYGKASAMSKLMAGDTAMKVTTEA VQIFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLAD*" /label="acdA CDS" gene complement(3276585..3277724) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /label="acdA gene" CDS complement(3277721..3279838) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative iron-sulphur-binding reductase" /protein_id="NP_391599.1" /db_xref="EnsemblGenomes-Gn:BSU37180" /db_xref="EnsemblGenomes-Tr:CAB15746" /db_xref="GOA:P45866" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11311" /db_xref="UniProtKB/Swiss-Prot:P45866" /translation="MSGFLIANALLFLIVTAYAVYLFVYLVKTRLAYIKLGQKEQFDQ RFKERLHAIWVNVFGQKKLLKDKKSGIIHVMFFYGFILVQFGAIDFIIKGLAPGRNLS LGPVYPAFTFFQEIVTFLILIAVGWAFYRRYIEKLVRLKRGFKAGLVLIFIGGLMLTV LLGNGMNLIWHEHGLSWSEPIASGIAFMLSGVGKTGAAVIFYIAWWIHLLFLLSFLVY VPQSKHAHLIAGPANVFFNRMESAGKLEKIDFTDETKESYGAGKIEDFRQSQLLDLYA CVECGRCTNMCPATGTGKMLSPMDLILRLRDHLTEKGAAVTSRSPWVPAAAFRHTRGN QLAAASAGSGSQEAAAALDYNPSLIGDVITEEEIWACTTCRNCEDQCPVMNEHVDKII DLRRYLVLTEGKMDSDAQRAMTSIERQGNPWGLNRKERENWRDEAPDAEIPTVKEMKK EGKEFEYLFWVGSMGSYDNRSQKIAISFAKLLNHAGVSFAILGNKEKNSGDTPRRLGN EFLFQELAEKNISEFEKNDVKKIVTIDPHAYNLFKNEYPDFGFEGEVYHHTEVLAELV KNGKLRPQHPLHETITFHDSCYLGRYNEVYDPPREILKAIPGVQLVEMERSRETGMCC GAGGGLMWMEEETGNRINVARTEQALAVNPSVISSGCPYCLTMLGDGTKAKEAEDQVK TYDVVELLAQSVLGADLKMGEKQ*" /label="fadF CDS" gene complement(3277721..3279838) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /label="fadF gene" S_feature complement(3279839..3279897) /Source="Nicolas_S_feature" /locus_tag="new_3816500_3816558_c" /HighExp="T0.30H, S6, BC, S8, S7, Sw, S5, S4, Lbstat, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1444" promotor_-10 complement(3279898..3279917) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3279911) /Source="Nicolas_upshifts" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3279931..3279938) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3279937..3279943 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3279957..3279968 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3279962 /Source="Nicolas_upshifts" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="upshifts" CDS 3279993..3281189 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14973018, 16514141, 18820022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16514141, 18820022; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase (phospholipase D family)" /protein_id="NP_391600.1" /db_xref="EnsemblGenomes-Gn:BSU37190" /db_xref="EnsemblGenomes-Tr:CAB15747" /db_xref="GOA:P45865" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="SubtiList:BG11310" /db_xref="UniProtKB/Swiss-Prot:P45865" /translation="MKVFIVIMIIVVIFFALILLDIFMGRAGYRKKAYEPVFSKKKSD IELIHCGADLVERMMNDIRQAASSVHMMFFIMKNDEVSHNMYTLLKTKAQAGVSVYLL LDWAGCRAIKKTALQTMKNAGVHVHVMNRPRFPFFFFHMQKRNHRKITVIDGKIGYIG GFNIAEEYLGKKAKFGNWEDYHLRMIGEGVHDLQTLFASDLKRNTGIELGSDVWPKLQ QGTISHKIYATDGYSLENIYLANIAQAKNRLTVCTPYYIPSKPLQEALINARKNGVSV RIIVPMKSDHPLVREAAFTYYSELLDAGCLIYRYYQGFYHVKALIIDDHLSIIGTANF DKRSLFLNEEVNVEIDDEAFTSEVYATIEEDMKKSELLTMEDFSKRTFRQRPAEWLGR ALSYFL*" /label="clsB CDS" gene 3279993..3281189 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /label="clsB gene" S_feature complement(3280185..3281063) /Source="Nicolas_S_feature" /locus_tag="new_3816846_3817724_c" /HighExp="S4, S5, S3, S6, S7, S8, BT, B36, LoTm, B60" /AntisenseName="clsB" /AntisenseCor="0.84883232203587" /AntisenseRegPval="-75.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1445" promotor_-10 complement(3281053..3281071) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3281064) /Source="Nicolas_upshifts" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3281087..3281092) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3281202..3282164 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /EC_number="3.-.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8614629, 22961846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8614629, 22961846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UV DNA damage repair endonuclease" /protein_id="NP_391601.1" /db_xref="EnsemblGenomes-Gn:BSU37200" /db_xref="EnsemblGenomes-Tr:CAB15748" /db_xref="GOA:P45864" /db_xref="InterPro:IPR004601" /db_xref="InterPro:IPR023520" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11309" /db_xref="UniProtKB/Swiss-Prot:P45864" /translation="MIFRFGFVSNAMSLWDASPAKTLTFARYSKLSKTERKEALLTVT KANLRNTMRTLHYIIGHGIPLYRFSSSIVPLATHPDVMWDFVTPFQKEFREIGELVKT HQLRTSFHPNQFTLFTSPKESVTKNAVTDMAYHYRMLEAMGIADRSVINIHIGGAYGN KDTATAQFHQNIKQLPQEIKERMTLENDDKTYTTEETLQVCEQEDVPFVFDFHHFYAN PDDHADLNVALPRMIKTWERIGLQPKVHLSSPKSEQAIRSHADYVDANFLLPLLERFR QWGTNIDFMIEAKQKDKALLRLMDELSSIRGVKRIGGGALQWKS*" /label="uvsE CDS" gene 3281202..3282164 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /label="uvsE gene" promotor_-35 3282178..3282184 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3282199..3282217 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3282199 /Source="Nicolas_upshifts" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="upshifts" CDS 3282245..3282517 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391602.1" /db_xref="EnsemblGenomes-Gn:BSU37210" /db_xref="EnsemblGenomes-Tr:CAB15749" /db_xref="InterPro:IPR035895" /db_xref="SubtiList:BG11308" /db_xref="UniProtKB/Swiss-Prot:P45863" /translation="MKNIKSLKVAAQAFTLRNLIHLYKMCHSGSHEVYIYSKKTMCKI KSLIELETFRMAHNEKEYLIVVEGTKASQLIEKFQNLIEPAEREAL*" /label="ywjC CDS" gene 3282245..3282517 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /label="ywjC gene" downshifts complement(3282251) /Source="Nicolas_upshifts" /id="D1923" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="1.03516" /MaxDrop="5.08765" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 3282507 /Source="Nicolas_upshifts" /id="D1924" /incds=0 /nref=54 /ntot=128 /MaxReadThrough="4.49396" /MaxDrop="7.49636" /score="14.0189582" /energy="-10" /TU="U2932" /idTUdmin="U2930" /TUdmin=178 /isTUend="FALSE" /label="downshifts" S_feature 3282552..3282958 /Source="Nicolas_S_feature" /locus_tag="new_3819213_3819619" /HighExp="Etha, C30, Sw, Gly, C90, M/G, BC, Salt, Fru, G135" /AntisenseName="ywjB" /AntisenseCor="0.2646821361217" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1446" CDS complement(3282559..3283083) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391603.1" /db_xref="EnsemblGenomes-Gn:BSU37220" /db_xref="EnsemblGenomes-Tr:CAB15750" /db_xref="GOA:P45862" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG11307" /db_xref="UniProtKB/Swiss-Prot:P45862" /translation="MERKTVLYIAVSLDGMIAKEDGSIDWLDEFEGEGDNGYSDFYQT VDTVILGRSTYEHVKVLTPVFPYQDKTCYVFTGSPDSYQDEHVTFINEGARAFTARLK QEKGSNIWIAGGAELVNDFMKEDAIDEFIITVIPVVLGSGIPLFHELTNETKLRLKGT KQFGQAVQLHYVRA*" /label="ywjB CDS" gene complement(3282559..3283083) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /label="ywjB gene" downshifts complement(3282581) /Source="Nicolas_upshifts" /id="D1925" /incds=0 /nref=194 /ntot=239 /MaxReadThrough="1.38978" /MaxDrop="6.19859" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3283093..3284820) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12119303, 12354229, 25652542; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC lipid transporter (ATP-binding protein)" /protein_id="NP_391604.1" /db_xref="EnsemblGenomes-Gn:BSU37230" /db_xref="EnsemblGenomes-Tr:CAB15751" /db_xref="GOA:P45861" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11306" /db_xref="UniProtKB/Swiss-Prot:P45861" /translation="MLRQFFSYYKPYKTLFFLDFFSAIAGGLMELSFPLIVNYFIDTL LPGRDWGLIIATSIGLFAVYALSSALQYIVTYWGHMLGINIETDMRKSLFDHLQKLSF KFYDNNKTGTLMSKLTNDLMYIGEVAHHGPEDLFIAVMTILGAFGVMLFINWQLALLT FIIMPIVIWLALYFNKKMTKAFTTLNKDIGDFSARVENNIGGIRLVQAFGNEAFEKER FAVNNQRFRVTKLSSYKIMAKNGSISYMLTRFVTLFVLLCGTWFVIRGSLSYGEFVAF VLLTNVLFRPIDKINAIIEMYPRGIAGFKSYMELMETEPDIQDSPDSKDVSGLKGNIR YKHVSFGYDDHHNVLNDINLSIQAGETVAFVGPSGAGKSTLCSLLPRFYEASEGDITI DGISIKDMTLSSLRGQIGVVQQDVFLFSGTLRENIAYGRLGASEEDIWQAVKQAHLEE LVHNMPDGLDTMIGERGVKLSGGQKQRLSIARMFLKNPSILILDEATSALDTETEAAI QKALQELSEGRTTLVIAHRLATIKDADRIVVVTNNGIEEQGRHQDLIEAGGLYSRLHQ AQFGQMVHR*" /label="ywjA CDS" gene complement(3283093..3284820) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /label="ywjA gene" promotor_-10 complement(3284854..3284873) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3284868) /Source="Nicolas_upshifts" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3284887..3284893) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3284909..3286411) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /EC_number="2.7.8.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14973018, 15743965, 16514141, 26025016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase" /protein_id="NP_391605.1" /db_xref="EnsemblGenomes-Gn:BSU37240" /db_xref="EnsemblGenomes-Tr:CAB15752" /db_xref="GOA:P45860" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG11305" /db_xref="UniProtKB/Swiss-Prot:P45860" /translation="MLKRRLEFFFLYMMLIGAYVIWFFPVSRLEFYGGLLCYISIILF SIYSLILENRTSQHTLLWIHILVFFPIVGYVFYLFSGQLYVKGKLFKTKRMYNREKLR KLFDKEETPEVTGLKDNQERFFTYSIRAAHMNINTKSNIKVLKNGEETFPDIFKAMRK AESYIHIEYYMFKSDMLGRGMMDIMMEKARQGVEVRFLYDAAGSMKLARRDIMRMKQA GVDIVPFSPLKYGFFNQKLNFRNHRKIVIIDGKTGFVGGLNVGKEYISRDPYIGFWRD THLRLEGEIVQTLHAIFMLDWEYVSNEVLIDQEEYNTPVPVEGGGIYQIVATGPDMKE SMSDLYYEMISSAQKSIWIATPYFVPNESIRTALKAAATKGVEVRVMVPEKNDSFLTQ YASRSYFPELLLEGIEVYSYQKGFMHQKVMIIDGDLASVGTANMDMRSFQLNFEVNVF FTDAEAIRTLEAHFEEDMQESEKLSPVGFYKRGVADRTKESFARLFSGVL*" /label="clsC CDS" gene complement(3284909..3286411) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /label="clsC gene" promotor_-10 complement(3286435..3286453) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3286453) /Source="Nicolas_upshifts" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3286468..3286474) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3286498..3286870) /Source="Nicolas_S_feature" /locus_tag="new_3823159_3823531_c" /HighExp="Lbtran, M40t45, nit, LBGtran, LBGstat, S0, ferm, M0t45, Lbstat, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30294500000000002" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S1447" downshifts complement(3286541) /Source="Nicolas_upshifts" /id="D1926" /incds=0 /nref=4 /ntot=19 /MaxReadThrough="2.94229" /MaxDrop="4.09744" /score="13.5274489" /energy="-11.4" /TU="NA" /idTUdmin="U2935" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3286897..3287568) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (gamma subunit)" /protein_id="NP_391606.1" /db_xref="EnsemblGenomes-Gn:BSU37250" /db_xref="EnsemblGenomes-Tr:CAB15753" /db_xref="GOA:P42177" /db_xref="InterPro:IPR003816" /db_xref="InterPro:IPR023234" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11084" /db_xref="UniProtKB/Swiss-Prot:P42177" /translation="MSGQILWGIMPYIVLTIFIGGHIYRYQHDQFGWTAKSSELLEKK KLAAGSTLFHWGLLCVVGGHVMGILIPEGVYASLGISEHMYHKMAIGAGLPAGIAACT GLVILTYRRLFDKRIRKTSSPSDILTLLLLLFMMLSGVAATFLNIDSKGFDYRTTVGP WFREIVLFRPDASLMESVPLWFKFHIVIGYVVFILWPFTRLVHVFSLPLKYLTRSYVV YRKRS*" /label="narI CDS" gene complement(3286897..3287568) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /label="narI gene" downshifts complement(3286915) /Source="Nicolas_upshifts" /id="D1927" /incds=0 /nref=4 /ntot=13 /MaxReadThrough="6.70789" /MaxDrop="4.50566" /score="27.8375931" /energy="-11.7" /TU="U2935" /idTUdmin="U2935" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(3287565..3288119) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase molybdenum cofactor assembly chaperone NarJ" /protein_id="NP_391607.1" /db_xref="EnsemblGenomes-Gn:BSU37260" /db_xref="EnsemblGenomes-Tr:CAB15754" /db_xref="GOA:P42178" /db_xref="InterPro:IPR003765" /db_xref="InterPro:IPR020945" /db_xref="InterPro:IPR036411" /db_xref="SubtiList:BG11083" /db_xref="UniProtKB/Swiss-Prot:P42178" /translation="MNTTDRQITFSALSCLLSYPDEEWRAELPDWKALIQEIGNRQIR EKLLHFFETSASYSPEALIEHYVYTFDFGKKTNMYVTYFNSGEQRERGIELLHLKNTY EQSGFLPTEKELPDYLPLMLEFAAAAEIEAARSVFEKYLSNVRELASRLEKNDSIYAE LLHVLLAALENIGVRESVEGAVQA*" /label="narJ CDS" gene complement(3287565..3288119) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /label="narJ gene" CDS complement(3288145..3289608) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (beta subunit)" /protein_id="NP_391608.1" /db_xref="EnsemblGenomes-Gn:BSU37270" /db_xref="EnsemblGenomes-Tr:CAB15755" /db_xref="GOA:P42176" /db_xref="InterPro:IPR006547" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR029263" /db_xref="SubtiList:BG11082" /db_xref="UniProtKB/Swiss-Prot:P42176" /translation="MKIKAQIGMVMNLDKCIGCHTCSVTCKNTWTNRSGAEYMYFNNV ETKPGIGYPKQWEDQDKYKGGWTLKKGKLELKSGSKTNRLAGLFYNPNQPSIDDYYEP WNYDYETLTNSPQKKHQPVARPKSSLTGDFMNIEWGPNWEDDLAGGHITGLEDPNVQK MEESIKTEFDDVFMMYLPRICEHCINPACVSSCPSGAMYKREEDGIVLVDQNACRSWR YCVSSCPYKKVYFNWQTNKAEKCTLCFPRLEAGLPTICSETCVGRIRYLGVMLYDADK VEEAASVENEKDLYHSQLDVFLDPNDPEVAKLAKEQGIPAEWIEAAQQSPIYKMIIDW KIALPLHPEYRTLPMVWYIPPLSPIMNLFEGKGSRQTAEDIFPAIDQMRIPIDYLAQL LTAGDTDHIRSTLKKMSVMRQYMRAVQTNKSIDPELISSVGLTEQQIEDMYRLLAIAK YDDRFVIPSSHREEVSDLYAEQGSCGLSFSGGPGSCF*" /label="narH CDS" gene complement(3288145..3289608) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /label="narH gene" CDS complement(3289598..3293284) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /EC_number="1.7.5.1" /EC_number="1.7.99.4" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11289299, 7557333, 7860592, 8846791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (alpha subunit)" /protein_id="NP_391609.2" /db_xref="EnsemblGenomes-Gn:BSU37280" /db_xref="EnsemblGenomes-Tr:CAB15756" /db_xref="GOA:P42175" /db_xref="InterPro:IPR006468" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="InterPro:IPR028189" /db_xref="SubtiList:BG11081" /db_xref="UniProtKB/Swiss-Prot:P42175" /translation="MKKKKRSPLFRRLNYFSPIEHHSNKHSQTTREDRDWENVYRNRW QYDKVVRSTHGVNCTGSCSWNIYVKNGIVTWEGQNLNYPSTGPDMPDFEPRGCPRGAS FSWYIYSPLRVKYPYVRGVLINLWREALQTHQNPLEAWKSIVENPEKAKSYKQARGKG GFVRAEWPEVLKLISASLLYTVMKYGPDRNVGFSPIPAMSMISHASGSRFMSLIGGPM LSFYDWYADLPPASPQIWGDQTDVPESSDWYNSGYIITWGSNVPLTRTPDAHFLAEAR YKGAKVISISPDFAESSKFADDWLSIRQGTDGALAMAMGHVILQEFYVNQETERFIEY AKQYTDFPFLVTLSKENGVYTAGRFLHAKDIGRKTKHDQWKPAVWDEQTSSFAIPQGT MGSRWDGQQKWNLHMIDEETGEPIEPRLSVLGIEDEIGTVRIPYFSNDGNKVLERDLP IKKMNLNGEETYITTVFDLILANYGVNRGIGERSAVSYDDPEPFTPAWQEQMTGIKKE AVVKIAREFAQNAIDTDGRSMIIVGAGINHWFNSDTIYRAVLNLVLLVGAQGVNGGGW AHYVGQEKLRPAEGWQTIATAKDWEGVPKLQNGTSFFYFATDQWRYEDQPISDLASPI AASSRYKHHADYNVLAARLGWLPSYPTFNQNGIDLYKEAEKAGAATPEDVGAYVASQL QEKKLKFAIEDPDNEVNFPRNLFVWRANLISSSGKGHEYFLKHLLGTTNGLMNDDSDS IRPEEIKWREQAPEGKLDLLINLDFRMAGTALYSDIVLPAATWYEKHDLSSTDMHPFI HPFAPAISAPWESKSDWDIFKALSKAVSDLAEEVDMEPVKEVVATPLLHDTMQELAQP FGKINDWSKGECEAIPGKTMPNIQVVERDYKHIFHKMTALGPNVALKPSGTKGMSWSI ADEYESLKQRLGEITSDSVAKGCPNISEAKQAAEAILTLSSTSNGKVAVKAWESLENI TNLKLKDLAEEREEECFTFEQITAQPKTVITSPAFTGSEKGGRRYSPFTTNVEKLIPW RTLTGRQSYYVDHELMMEFGETMATFKPILQHRPFLSKRPDQEGKEIVLNYLTPHNKW SVHSMYFDSLPMLTLFRGGPTVWMNKDDAEDTDIKDNDWIECFNRNGVVVARAVLSHR IPKGMAFMHHAQDRHINVPGTKLTNNRGGTHNSPTRIHVKPTQMIGGYAQLSYGFNYY GPTGNQRDLNVVIRKLKEVDWLED*" /label="narG CDS" gene complement(3289598..3293284) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /label="narG gene" misc_feature complement(3293315..3293334) /Source="Nicolas_upshift_promotors" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3293339) /Source="Nicolas_upshifts" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3293341..3293470) /Source="Nicolas_S_feature" /locus_tag="new_3830002_3830131_c" /HighExp="Lbtran, M40t45, LBGtran, ferm, M0t45, nit, S0, Lbstat, LBGstat, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1448" CDS complement(3293480..3293956) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 11698370, 16428414, 22178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 11698370, 16428414, 22178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_391610.1" /db_xref="EnsemblGenomes-Gn:BSU37290" /db_xref="EnsemblGenomes-Tr:CAB15757" /db_xref="GOA:P46910" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018490" /db_xref="SubtiList:BG11345" /db_xref="UniProtKB/Swiss-Prot:P46910" /translation="MNQCDYLLFLKQLPMFNEVPLSIVETLLKNGTFIRGSCDQSPSF LHSQSVYIVLKGSVRFMDTRLPEGSKTVALWEKGDVFPIDEKGGLYLSPFISVNATSD ILILNIPYYIFKKMMSYHPQLQMNFLAMLQQNVFCSYQLFLRYLHTSQDENAEPGS*" /label="arfM CDS" gene complement(3293480..3293956) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /label="arfM gene" downshifts complement(3293515) /Source="Nicolas_upshifts" /id="D1928" /incds=0 /nref=10 /ntot=39 /MaxReadThrough="5.03469" /MaxDrop="3.83412" /score="30.7487171" /energy="-10.5" /TU="U2936" /idTUdmin="U2936" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3293979..3293998) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-10" upshifts complement(3293991) /Source="Nicolas_upshifts" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="upshifts" promotor_-35 complement(3294013..3294016) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-35" upshifts 3294063 /Source="Nicolas_upshifts" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3294066..3294085 /Source="Nicolas_upshift_promotors" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3294100..3294819 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16428414, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391611.1" /db_xref="EnsemblGenomes-Gn:BSU37300" /db_xref="EnsemblGenomes-Tr:CAB15758" /db_xref="GOA:P46909" /db_xref="InterPro:IPR025576" /db_xref="SubtiList:BG11344" /db_xref="UniProtKB/Swiss-Prot:P46909" /translation="MKALIPKQHGAWAMLLIPFLLGMVKGGPVIWHIPLFLGWLFLYL AVYPVTLALKKKQSKPYQKWMCYYGFPTCCFLMISVFHKPPLIWVGVSLLPLFLIHMY FARRKNERALLNDVAGVLFFCSGGFASCWLGMGTLDGWAWFIFLQSALFFIGSSFYVK SVIRERKNRAFAYWSWGYHLLLPFLSALFGAGWAFLAFIPSSLRAWFFHGRDWPVKTI GILEIVNACFFLAVMCLFITR*" /label="ywiC CDS" gene 3294100..3294819 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /label="ywiC gene" downshifts 3294803 /Source="Nicolas_upshifts" /id="D1929" /incds=0 /nref=14 /ntot=34 /MaxReadThrough="2.00369" /MaxDrop="5.63285" /score="-3.54009378" /energy="-5.8" /TU="NA" /idTUdmin="U2937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3294851..3295567) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 16796679, 21068385, 23046954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 16796679, 21068385, 23046954; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of anaerobic metabolism (FNR/CAP family)" /protein_id="NP_391612.1" /db_xref="EnsemblGenomes-Gn:BSU37310" /db_xref="EnsemblGenomes-Tr:CAB15759" /db_xref="GOA:P46908" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR012318" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018335" /db_xref="InterPro:IPR018490" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11343" /db_xref="UniProtKB/Swiss-Prot:P46908" /translation="MNFLSVRPSDSDLISSDLYELLESISTKRKMEKHTYLFREGMDA EELYLIQSGLIEIGKLTSDGKDLTLRICQKHDIVGELTLFTEEPRYMLSAKVLEDGEV LVINKNKLEKELIQNGALTFEFMKWMSTHLRKIQSKIRDLLLHGKKGALYSTLIRLSN SYGVERSDGILINIVLTNQDLAKFCAAARESVNRMLGDLRKKGVISIDESGKIILHKR DYLRCEIECENCPLEICNID*" /label="fnr CDS" gene complement(3294851..3295567) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /label="fnr gene" downshifts complement(3294853) /Source="Nicolas_upshifts" /id="D1930" /incds=0 /nref=116 /ntot=238 /MaxReadThrough="3.06242" /MaxDrop="8.21489" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-84" /isTUend="FALSE" /label="downshifts" downshifts complement(3294923) /Source="Nicolas_upshifts" /id="D1931" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.51297" /MaxDrop="3.71248" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" misc_feature complement(3295593..3295612) /Source="Nicolas_upshift_promotors" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3295605) /Source="Nicolas_upshifts" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3295666..3296853) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 15849754, 16796679, 16850406, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 15849754, 16796679, 16850406, 26786044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite extrusion permease" /protein_id="NP_391613.2" /db_xref="EnsemblGenomes-Gn:BSU37320" /db_xref="EnsemblGenomes-Tr:CAB15760" /db_xref="GOA:P46907" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11342" /db_xref="UniProtKB/Swiss-Prot:P46907" /translation="MINRQHIQLSLQSLSLVAGFMVWVLISSLISQITLDIHLSKGEI SLVTAIPVILGSLLRIPLGYLTNRFGARLMFMVSFILLLFPVFWISIADSLFDLIAGG FFLGIGGAVFSIGVTSLPKYYPKEKHGVVNGIYGAGNIGTAVTTFAAPVIAQAVGWKS TVQMYLILLAVFALLHVLFGDRHEKKVKVSVKTQIKAVYRNHVLWFLSLFYFITFGAF VAFTIYLPNFLVEHFGLNPADAGLRTAGFIAVSTLLRPAGGFLADKMSPLRILMFVFA GLTLSGIILSFSPTIGLYTFGSLTVAVCSGIGNGTVFKLVPFYFSKQAGIANGIVSAM GGLGGFFPPLILASVFQATGQYAIGFMALSEVALASFVLVIWMYWQERMKTHTERNSQ SIN*" /label="narK CDS" gene complement(3295666..3296853) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /label="narK gene" misc_feature complement(3296883..3296902) /Source="Nicolas_upshift_promotors" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3296901) /Source="Nicolas_upshifts" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3296989..3298659) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /EC_number="6.1.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8289305, 9862121" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8289305, 9862121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginyl-tRNA synthetase" /protein_id="NP_391614.1" /db_xref="EnsemblGenomes-Gn:BSU37330" /db_xref="EnsemblGenomes-Tr:CAB15761" /db_xref="GOA:P46906" /db_xref="InterPro:IPR001278" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR005148" /db_xref="InterPro:IPR008909" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR035684" /db_xref="InterPro:IPR036695" /db_xref="SubtiList:BG11341" /db_xref="UniProtKB/Swiss-Prot:P46906" /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLETPKDKTHG DYSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTK LIPSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAG YDVSREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEY GDRFVNEEESERLAFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKAL EALREKGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDK LINVWGADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVT MRDLIEEVGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQ GEEQGLKPAADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASA LHSFYNAEKVIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM*" /label="argS CDS" gene complement(3296989..3298659) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /label="argS gene" downshifts complement(3296991) /Source="Nicolas_upshifts" /id="D1932" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="1.71727" /MaxDrop="6.56513" /score="23.3947976" /energy="-12.5" /TU="NA" /idTUdmin="U2941" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3298656..3299084) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_391615.1" /db_xref="EnsemblGenomes-Gn:BSU37340" /db_xref="EnsemblGenomes-Tr:CAB15762" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015231" /db_xref="PDB:1R0U" /db_xref="SubtiList:BG14161" /db_xref="UniProtKB/Swiss-Prot:O07624" /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYY EEHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVTGASTIAKYKMSFGELELKTSTKS IQSDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA*" /label="ywiB CDS" gene complement(3298656..3299084) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /label="ywiB gene" misc_feature 3299152..3299166 /Source="Nicolas_upshift_promotors" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3299152..3299171) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3299159 /Source="Nicolas_upshifts" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3299168) /Source="Nicolas_upshifts" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3299188..3299191) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3299223..3299242) /Source="Nicolas_upshift_promotors" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3299235) /Source="Nicolas_upshifts" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="upshifts" SCAR join(3299264,3299271) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs09" N_region 3299265..3299270 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs09" S_feature <3299271..3301749 /Source="Nicolas_S_feature" /locus_tag="new_3842996_3845478" /HighExp="Lbstat, nit, ferm, BI, M0t90, S2, M40t90, BT, M0t45, GM 150" /AntisenseName="ywhL" /AntisenseCor="7.7827453562424306E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.99, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1450" CDS complement(3299272..3300648) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12073041" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391624.1" /db_xref="EnsemblGenomes-Gn:BSU37440" /db_xref="EnsemblGenomes-Tr:CAB15771" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12464" /db_xref="UniProtKB/Swiss-Prot:P71004" /translation="MKKNDLSALQENCFCFCDEEISREAPFQVPIDFPEGFKVDTAEA SAAVTWSTDNLSCISEPCLIQTGPEPEDIGVRYAVRVQGTITLLVSVSPVRNQYGQGD GAVSVIHTEEIDQVVYYAAQSGRCPDFSQITVEDLLIVPPFYGSPLTVAGTLVLPPSP DPQSYVFTANTGDSTVSVIDADLNTVVKTIPFSDVPTNLGVTFDKAFTYVLHGNTNLV SVIDNKTLTIINTITVGGGPRKIEFDPTDEFAYVMAAGSIYVINTASQSVIDVIPIPG ALDFALDPNGQYVYTANGSSWSVDKYDVNTGQLVESIIDTFEFPSLITTPYAGNFAYV LNGELWPKGVTEISLSPLSRGGDFSRLFETLRTIVFSLDSTRAYFLEPYSEPFLINNL YVVNTARQRIIANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYRTSDYTAVTVIPVG AGPSAIAM*" /label="ywhL CDS" gene complement(3299272..3300648) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /label="ywhL gene" CDS complement(3300687..3302042) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12073041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073041; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DNA helicase PcrA" /protein_id="NP_391625.1" /db_xref="EnsemblGenomes-Gn:BSU37450" /db_xref="EnsemblGenomes-Tr:CAB15772" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12463" /db_xref="UniProtKB/Swiss-Prot:P71003" /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFV VDPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRN QYGQGDGAVSVIHNAEIDQVVYYSDESDDCPDISDITIENLVVVPPFYGSPLSVTGTI VLVPEPEPVYAFTANPNDQSVSVIDTNTDTVVTTIALPYNPAGIEITPDKSAVFVLHP NNNVISVIDYDTLTVTATILLDQPPRLIRFIPNHEFAYVFTGTAVYVIGIDTLTVDRS IPVEGYDVAIDPNGLFAYVLNFGIVQKVDLTTGEVTGTIERELIVSTIETNWPERYAY VLEQEFFFNYLTVIDLNTFTISSTQELEYEGEYRMFTSGAEVYLYDGFTGNLYSVSPN GAGVIGNVPQSATDYAFTPNGDFLYATRFIEQSIIVYNTDDYSEETVISLGVSPGAIT I*" /label="ywhK CDS" gene complement(3300687..3302042) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /label="ywhK gene" promotor_-10 complement(3302078..3302097) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3302096) /Source="Nicolas_upshifts" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3302110..3302119) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3302222..3302241 /Source="Nicolas_upshift_promotors" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3302223 /Source="Nicolas_upshifts" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3302268) /Source="Nicolas_upshifts" /id="D1937" /incds=0 /nref=7 /ntot=59 /MaxReadThrough="2.35357" /MaxDrop="4.85842" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=1867 /isTUend="FALSE" /label="downshifts" CDS 3302272..3303417 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase anti-activator of ComA" /protein_id="NP_391626.1" /db_xref="EnsemblGenomes-Gn:BSU37460" /db_xref="EnsemblGenomes-Tr:CAB15773" /db_xref="GOA:P71002" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3ULQ" /db_xref="PDB:4I9C" /db_xref="PDB:4I9E" /db_xref="SubtiList:BG11968" /db_xref="UniProtKB/Swiss-Prot:P71002" /translation="MTGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQME EDQDLHLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYY FNFFRGMYELDQREYLSAIKFFKKAESKLIFVKDRIEKAEFFFKMSESYYYMKQTYFS MDYARQAYEIYKEHEAYNIRLLQCHSLFATNFLDLKQYEDAISHFQKAYSMAEAEKQP QLMGRTLYNIGLCKNSQSQYEDAIPYFKRAIAVFEESNILPSLPQAYFLITQIHYKLG KIDKAHEYHSKGMAYSQKAGDVIYLSEFEFLKSLYLSGPDEEAIQGFFDFLESKMLYA DLEDFAIDVAKYYHERKNFQKASAYFLKVEQVRQLIQGGVSLYEIEV*" /label="rapF CDS" gene 3302272..3303417 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /label="rapF gene" promotor_-35 3303276..3303280 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3303297..3303316 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3303304 /Source="Nicolas_upshifts" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3303387) /Source="Nicolas_upshifts" /id="D1938" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="1.70728" /MaxDrop="2.74755" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 3303401..3303520 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type f: factor" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapF" /protein_id="NP_391627.1" /db_xref="EnsemblGenomes-Gn:BSU37470" /db_xref="EnsemblGenomes-Tr:CAB15774" /db_xref="GOA:P71001" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11960" /db_xref="UniProtKB/Swiss-Prot:P71001" /translation="MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI*" /label="phrF CDS" gene 3303401..3303520 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /label="phrF gene" downshifts 3303505 /Source="Nicolas_upshifts" /id="D1939" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="5.48985" /MaxDrop="6.14096" /score="19.6493244" /energy="-9.9" /TU="U2946" /idTUdmin="U2947" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" S_feature 3303550..3303618 /Source="Nicolas_S_feature" /locus_tag="new_3847279_3847347" /HighExp="S2, S3, S4, S5, S6, S1, BT, S7, S8, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.921" /TUlongSig="NA" /TUlongPSig="NA" /label="S1451" CDS 3303619..3304092 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA editing enzyme" /protein_id="NP_391628.1" /db_xref="EnsemblGenomes-Gn:BSU37480" /db_xref="EnsemblGenomes-Tr:CAB15775" /db_xref="GOA:P71000" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12462" /db_xref="UniProtKB/Swiss-Prot:P71000" /translation="MSLKSVRTHFTQWNRENDVTEFETSSATVEQAAETIGVSLSRIA KSLSFRGEGDQVILIVAAGDAKIDNKKSRQTFGFKARMLSPNEVLEQTGHEIGGVCPF GLAHDPEVYLDVSLKRFQTVFPACGSRNSAIELTPKELSEFSFSKVWIDVCKDWE*" /label="ywhH CDS" gene 3303619..3304092 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /label="ywhH gene" downshifts 3304081 /Source="Nicolas_upshifts" /id="D1940" /incds=0 /nref=30 /ntot=156 /MaxReadThrough="2.85314" /MaxDrop="4.40065" /score="-6.80415499" /energy="-11.3" /TU="NA" /idTUdmin="U2946" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3304124..3304996) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /EC_number="3.5.3.11" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9723923, 10931887, 24678831, 28807600, 28291380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10931887, 24678831, 28807600, 28291380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="agmatinase" /protein_id="NP_391629.1" /db_xref="EnsemblGenomes-Gn:BSU37490" /db_xref="EnsemblGenomes-Tr:CAB15776" /db_xref="GOA:P70999" /db_xref="InterPro:IPR005925" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG12461" /db_xref="UniProtKB/Swiss-Prot:P70999" /translation="MRFDEAYSGKVFIASRPEWEEADAILYGMPMDWTVSYRPGSRFG PSRIREVSIGLEEYSPYLDRDLADLNFFDAGDIPLPFGNPQRSLDMIEEYVDSILEKG KFPMGMGGEHLVSWPVIKAMYKKYPDLAIIHFDAHTDLRVDYEGEPLSHSTPIRKAAE LIGPHNVYSFGIRSGMKEEFEWAKENGMHISKFEVLEPLKEVLPKLAGRPVYVTIDID VLDPAHAPGTGTVDAGGITSKELLASVHEIARSEVNVKGADLVEVAPVYDHSEQTANT ASKIIREMLLGFVK*" /label="speB CDS" gene complement(3304124..3304996) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /label="speB gene" downshifts complement(3304135) /Source="Nicolas_upshifts" /id="D1941" /incds=0 /nref=49 /ntot=171 /MaxReadThrough="2.5482" /MaxDrop="5.46925" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3304201) /Source="Nicolas_upshifts" /id="D1942" /incds=1 /nref=8 /ntot=50 /MaxReadThrough="5.83631" /MaxDrop="3.87062" /score="29.5788849" /energy="-11.3" /TU="U2948" /idTUdmin="U2948" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(3305057..3305887) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /EC_number="2.5.1.16" /function="16.3: Control" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9723923, 26735940, 28546427, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 26735940, 28546427, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermidine synthase; polyamine metabolism" /protein_id="NP_391630.1" /db_xref="EnsemblGenomes-Gn:BSU37500" /db_xref="EnsemblGenomes-Tr:CAB15777" /db_xref="GOA:P70998" /db_xref="InterPro:IPR001045" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030373" /db_xref="InterPro:IPR030374" /db_xref="InterPro:IPR035246" /db_xref="InterPro:IPR037163" /db_xref="PDB:1IY9" /db_xref="SubtiList:BG12460" /db_xref="UniProtKB/Swiss-Prot:P70998" /translation="MSELWYTEKQTKNFGITMKVNKTLHTEQTEFQHLEMVETEEFGN MLFLDGMVMTSEKDEFVYHEMVAHVPLFTHPNPEHVLVVGGGDGGVIREILKHPSVKK ATLVDIDGKVIEYSKKFLPSIAGKLDDPRVDVQVDDGFMHIAKSENQYDVIMVDSTEP VGPAVNLFTKGFYAGIAKALKEDGIFVAQTDNPWFTPELITNVQRDVKEIFPITKLYT ANIPTYPSGLWTFTIGSKKYDPLAVEDSRFFDIETKYYTKDIHKAAFVLPKFVSDLIK *" /label="speE CDS" gene complement(3305057..3305887) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /label="speE gene" S_feature complement(3305888..3305983) /Source="Nicolas_S_feature" /locus_tag="new_3849617_3849712_c" /HighExp="Paraq, G180, Oxctl, H2O2, LBGexp, G150, G135, C30, dia15, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1452" promotor_-10 complement(3305971..3305990) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3305982) /Source="Nicolas_upshifts" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3306003..3306010) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3306028..3306033 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3306049..3306067 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3306051 /Source="Nicolas_upshifts" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="upshifts" CDS 3306089..3308164 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10767540, 11567005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10767540, 11567005; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation specific penicillin-binding protein 2D" /protein_id="NP_391631.2" /db_xref="EnsemblGenomes-Gn:BSU37510" /db_xref="EnsemblGenomes-Tr:CAB15778" /db_xref="GOA:P70997" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG12459" /db_xref="UniProtKB/Swiss-Prot:P70997" /translation="MDAMTNKRLRLTLKTVRAFIFLGAFAALAAAAVFMTVILIAKYQ GAPSVQVPQSTILYASDGSKLGETNYGEKRYWVPLKDMNPTIVKATVAIEDQNFYDHH GFDYKRMAGAALADLKAFAKVQGASTITQQYARNLYLEHDKTWKRKWNEAFYTIRLEQ NYSKDEILEGYLNTIYYGHGAYGIEAASRLYFGKHAKNLTDAEAALLAGIPKGPSGYS PYVNETKAKERQKTIVRMMEKQQMISQKKADELIKEPLSYQPLNKQVSKRKAPYFYDN AMRELEKKLGMTREQIETSGLNVYTTVDKRMQRIAEETITETVNAGSDIQVGFSAIDP RTGNVLALVGGRDYQKSPFDRTTQAKRQPASTIKPLLYYKAIQSGFTPVTLMKSEETE FQIDAKGETYSPSNYNGYYANKPITLLQALALSDNIYAVKTHLFLGTNKLVKTAKEFG ITAHLQALPSLALGTEPVRPIEMVNAYAMLANGGKKIEPTFISRVTDAAGHVLYENPN QHKQVLDEKAAFVTASMMTGMFDIDLNGYTSVTGRTIANRLTRTYAGKSGTTSADSWM IGFNPKLAAGVWTGYDKNSTIDSVEEKSYAKTIWADFMEDALKGEPETAFKPPKGVTG VYIDPETGYSSGPGCAAKHYTYFVKGTEPANVCYGAEPAKQTKDRLPSKEKPASEKKW WDKWLGRHH*" /label="pbpG CDS" gene 3306089..3308164 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /label="pbpG gene" downshifts complement(3308217) /Source="Nicolas_upshifts" /id="D1943" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="1.43573" /MaxDrop="3.61075" /score="-7.59753556" /energy="-10.7" /TU="NA" /idTUdmin="U2951" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(3308341..3308456) /Source="Nicolas_S_feature" /locus_tag="new_3852070_3852185_c" /HighExp="Sw, C90, BI, dia5, dia15, Diami, LBGexp, M0t45, Lbexp, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1453" downshifts complement(3308384) /Source="Nicolas_upshifts" /id="D1944" /incds=0 /nref=198 /ntot=248 /MaxReadThrough="3.25498" /MaxDrop="6.4287" /score="-7.59753556" /energy="-10.7" /TU="U2951,U2952" /idTUdmin="U2952" /TUdmin="-156" /isTUend="FALSE" /label="downshifts" CDS complement(3308457..3308975) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391632.1" /db_xref="EnsemblGenomes-Gn:BSU37520" /db_xref="EnsemblGenomes-Tr:CAB15779" /db_xref="InterPro:IPR014852" /db_xref="SubtiList:BG12458" /db_xref="UniProtKB/Swiss-Prot:P70996" /translation="MEEKKKKSIGFNIIKSDPTDGHGGFGVGALSLDNISPVFVDVEE KEAFVDIGAMHARSTVEKGIKFLPNKEEVPNGKPYWLVWVTIDRKEEGPYYAGVTACE MTVDRSIRRGYKSLPEHVNLMDKSMKRKIIVDKMDDSSKRVLGEFLKKHDQGLWDRSS DELKTSLLPENN*" /label="ywhD CDS" gene complement(3308457..3308975) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /label="ywhD gene" CDS complement(3308989..3309648) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /EC_number="3.4.24.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase; integral membrane protein" /protein_id="NP_391633.1" /db_xref="EnsemblGenomes-Gn:BSU37530" /db_xref="EnsemblGenomes-Tr:CAB15780" /db_xref="GOA:P70995" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG12457" /db_xref="UniProtKB/Swiss-Prot:P70995" /translation="MDRFLYYPLSLMPYLVITLIVSFTMHELAHAYVAYKFGDDTAKK QGRLTLNPIKHLDPFGTILILVAGFGWARPIPVNRRFFKKPRLAGVLVSIAGPVSNLI LAFIGFFLLVLMHAYGMEMLAAFSTGLDQFFSIWIQLNLVLFLFNLLPLPPLDGYRII EDLVPPGVRAKMTQAESYGFIVFLVLFVTPLGSYVLWPMLNAGRDSILKLFSAIFQPL L*" /label="ywhC CDS" gene complement(3308989..3309648) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /label="ywhC gene" promotor_-35 3309671..3309674 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3309684..3309703) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3309689..3309708 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3309692 /Source="Nicolas_upshifts" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3309702) /Source="Nicolas_upshifts" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3309704..3309987) /Source="Nicolas_S_feature" /locus_tag="new_3853433_3853716_c" /HighExp="Diami, dia5, dia15, C90, Etha, Sw, H2O2, G135, M40t45, Lbtran" /AntisenseName="ywhB" /AntisenseCor="0.10541372702249199" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1454" promotor_-35 complement(3309718..3309725) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3309757..3309945 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /EC_number="5.3.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12051677, 14624569, 14730980, 15301547, 17902707" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12051677, 14624569, 14730980, 15301547, 17902707; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxymuconate tautomerase (promiscuous)" /protein_id="NP_391634.1" /db_xref="EnsemblGenomes-Gn:BSU37540" /db_xref="EnsemblGenomes-Tr:CAB15781" /db_xref="GOA:P70994" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="InterPro:IPR018191" /db_xref="PDB:2OP8" /db_xref="PDB:2OPA" /db_xref="SubtiList:BG12456" /db_xref="UniProtKB/Swiss-Prot:P70994" /translation="MPYVTVKMLEGRTDEQKRNLVEKVTEAVKETTGASEEKIVVFIE EMRKDHYAVAGKRLSDME*" /label="hmtB CDS" gene 3309757..3309945 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /label="hmtB gene" downshifts 3309934 /Source="Nicolas_upshifts" /id="D1945" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="1.74275" /MaxDrop="4.93207" /score="4.21502693" /energy="-10.5" /TU="NA" /idTUdmin="U2950" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3309988..3310407) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391635.1" /db_xref="EnsemblGenomes-Gn:BSU37550" /db_xref="EnsemblGenomes-Tr:CAB15782" /db_xref="GOA:P70993" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12455" /db_xref="UniProtKB/Swiss-Prot:P70993" /translation="MDHDKLEANLLDHALTKYLKSTKQLDEATVPKHVNNVRGFILRI IYRHGSCTIKDILKEVTLSPSATTTALNHLEQEGFIERSRNNNDRRTVWITLSESGRG AAEQMIENRQQLIDGMFERLTAEEKKTFLAIIAKLAQ*" /label="ywhA CDS" gene complement(3309988..3310407) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /label="ywhA gene" promotor_-10 complement(3310457..3310476) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3310468) /Source="Nicolas_upshifts" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3310491..3310498) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3310527..3312443) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9353933, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9353933, 15831787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_391636.2" /db_xref="EnsemblGenomes-Gn:BSU37560" /db_xref="EnsemblGenomes-Tr:CAB15783" /db_xref="GOA:P18256" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10421" /db_xref="UniProtKB/Swiss-Prot:P18256" /translation="MSKHVHIQLPDGQIQEYPKGITIKEAAGSISSSLQKKAAAGQVN GKLVDLSFKLEEDAELSIVTLDSQEGLQVLRHTTAHVLAQAVKRLYGEVSLGVGPVIL DGFYYDMKLGKSLASGDLEAIEKEMKNIINENLEIKRIEVSYEEAEELFAQKDERLKL EILKDIPRGEDITLYQQGEFVDLCRGPHLPSTGMIKAFKLTRVSGAYWRGDSKNEVLQ RVYGVAFQKKKDLDAHLHMLEEAAKRDHRKLGKQLGLFMFSEEAPGMPFYLPKGQIVR NELERFSRELQTNAGYDEVRTPFMMNQRLWEQSGHWDHYRDNMYFSEVDDTRFAMKPM NCPGHMLIFKNSLYSYRDLPIRMAEFGQVHRHEYSGALNGMLRVRTFCQDDAHIFVRE DQIESEIKEAIRLIDEVYRTFGFEYSVELSTRPEDSLGDDSLWEASERALARVLEELG LSYEINEGDGAFYGPKIDFHIKDALKRSHQCATIQLDFQMPEKFDLTYINELNEKVRP VVIHRAVFGSIDRFFGILIEHYGGAFPVWLAPIQVQIIPVSHVHLDYCRKVQAELKQA GIRAGIDERNEKLGYKIRESQVQKIPYVLVLGDHEEQENAVNVRRFGHQQNEHVPFQT FKDKLVKQVENRGM*" /label="thrZ CDS" gene complement(3310527..3312443) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /label="thrZ gene" promotor_-10 complement(3311721..3311739) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3311726) /Source="Nicolas_upshifts" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3311756..3311760) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3312474) /Source="Nicolas_upshifts" /id="D1946" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.2774" /MaxDrop="3.56231" /score="36.3785359" /energy="-19.5" /TU="U2955" /idTUdmin="U2953" /TUdmin="-968" /isTUend="FALSE" /label="downshifts" misc_RNA complement(3312497..3312718) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /product="T-box" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTB RNA" gene complement(3312497..3312718) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /label="tboTB gene" misc_RNA complement(3312750..3312971) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTA RNA" gene complement(3312750..3312971) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /label="tboTA gene" S_feature complement(3313003..3313265) /Source="Nicolas_S_feature" /locus_tag="new_3856732_3856994_c" /HighExp="S8, S7, S6, S5, BT, Sw, B36, B60, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.61719100000000005" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1455" downshifts 3313014 /Source="Nicolas_upshifts" /id="D1947" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="0.92811" /MaxDrop="3.85666" /score="1.17237511" /energy="-8.3" /TU="NA" /idTUdmin="U2950" /TUdmin=3080 /isTUend="FALSE" /label="downshifts" downshifts complement(3313046) /Source="Nicolas_upshifts" /id="D1948" /incds=0 /nref=52 /ntot=200 /MaxReadThrough="6.68945" /MaxDrop="6.6969" /score="36.414771" /energy="-17.3" /TU="U2955" /idTUdmin="U2953" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3313053..3313208) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514011.1" /translation="MLFTVSREGRTAEIFLTQGKQLTAFEPYQGKQVSDTVMLRYSIF KPIIMCN*" /label="hypothetical protein CDS" gene complement(3313053..3313208) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /label="gene" promotor_-35 3313215..3313218 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3313227..3313240 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3313234 /Source="Nicolas_upshifts" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3313242..3313261) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3313265) /Source="Nicolas_upshifts" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3313275..3313281) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3313288..3314688) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11104814, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11104814, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="toxic compound efflux transporter (may export homoserine)" /protein_id="NP_391637.1" /db_xref="EnsemblGenomes-Gn:BSU37570" /db_xref="EnsemblGenomes-Tr:CAB15784" /db_xref="GOA:Q00538" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10420" /db_xref="UniProtKB/Swiss-Prot:Q00538" /translation="MKNSGSIQESTSSTGISVLIVLALGFLMATLDVTVVNVAMADMK NTLSMSLSGVTWVVDGYILTFASLLLAGGALADRFGSKTIYILGLAVFVMASCLCAAS INGQMLIAGRLIQGIGAALFMPSSLSLLAASYLDERARARMFGLWAALVSAASALGPF IGGVLVQLAGWQSIFLINVPIGAAALISAYRILSRVPGKSSRVNIIGHLLGMMALGFL SYALIQGPSAGWRSPVILVAFTAAVLAFVLFLLREISAKTPILPASLYKNGRFSAAQF IGFLLNFALFGGMFMLSLFLQEAGGASSFMAGVELLPMMAVFVIGNLLFARLANRFEA GQLMFVSMAVSCIIALLLFVLISPDFPYWQLAVLMSVMNLCTGITVPAMTTVIMQAAG QRHTNIAGAALNANRQIGALVGVAITGVIIHLSATWYAGAGFAFLMMGAAYSLAALLV WLFLAAHNGTAASEKM*" /label="mmr CDS" gene complement(3313288..3314688) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /label="mmr gene" CDS complement(3314688..3315158) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885456; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391638.1" /db_xref="EnsemblGenomes-Gn:BSU37580" /db_xref="EnsemblGenomes-Tr:CAB15785" /db_xref="GOA:P71047" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12454" /db_xref="UniProtKB/Swiss-Prot:P71047" /translation="MKMKSGMEQAVSVLLLLSRLPVQASLTSEAISQRLRVSPSYLKK LMRTLVQAGLAESLPGTKGGFTLTKPLADITLYDVYQAVEGRGSMYQGKGLLQSVFEG ESHCVLETVMAEIEDKWSNLMREESLQHVMDRVGELYDLEKIDDWVIKQVKGQL*" /label="ywgB CDS" gene complement(3314688..3315158) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /label="ywgB gene" downshifts complement(3315114) /Source="Nicolas_upshifts" /id="D1949" /incds=0 /nref=11 /ntot=145 /MaxReadThrough="2.78131" /MaxDrop="4.29115" /score="17.3758052" /energy="-11.2" /TU="NA" /idTUdmin="U2956" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3315270..3315770) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391639.1" /db_xref="EnsemblGenomes-Gn:BSU37590" /db_xref="EnsemblGenomes-Tr:CAB15786" /db_xref="SubtiList:BG12453" /db_xref="UniProtKB/Swiss-Prot:P71046" /translation="MLKEHAKLMKVFSDSGEIIGRKKLQKMIYIAKKMQFPFYEKYDF HFYGPYSEELTLQIEELCNLGFLHEVKEKKGGYFQYRYSLTETGSAFLDHADLDMPDM KGYIDSVNSRSSRFLELVSTILYFDGLEDEEKKEKVFTIKSKQKYTNEEYDEALQYIE ELKQIC*" /label="ywgA CDS" gene complement(3315270..3315770) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /label="ywgA gene" downshifts complement(3315273) /Source="Nicolas_upshifts" /id="D1950" /incds=0 /nref=9 /ntot=105 /MaxReadThrough="4.00805" /MaxDrop="6.12059" /score="17.3758052" /energy="-11.2" /TU="U2956,U2957" /idTUdmin="U2957" /TUdmin="-137" /isTUend="FALSE" /label="downshifts" CDS complement(3315806..3317107) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent nucleotide (pyro)phosphohydrolase" /protein_id="NP_391640.1" /db_xref="EnsemblGenomes-Gn:BSU37600" /db_xref="EnsemblGenomes-Tr:CAB15787" /db_xref="GOA:P39651" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG10639" /db_xref="UniProtKB/Swiss-Prot:P39651" /translation="MAYPNGKLSEEKVFKDPVHRYVHVRDKLIWDLIGTREFQRLRRI KQLGTTYLTFHGAEHSRFNHSLGVYEIVRRMVDDVFKGRPEWDDSERELCLAAALLHD LGHGPFSHSFEKVFHLDHEDFTRGIILGDTEVNQVLRKVSPGFPQDVAEVIAKTYKNK QVVSLISSQIDADRMDYLQRDAYYTGVSYGHFDMERILRVMRPREDQIVIKESGMHAV EDYIMSRYQMYWQVYFHPVTRSAEVILTKILHRAKQLHDEGYVFTHAPVHFYSIFEGK LTLEDYVKLDESIILYYFQAWEDEEDAILSDLCRRFINRQLFQYVEFNPNEEMSAYFE LTSLFKEAGIDPSYYLVVDSSSDLPYDFYRPGEEEERLPIHLLTQNGQIKELSRQSAI VESISGKRRTDHKLYYPKDLICDGTKHPEAKMKIRQLLGLT*" /label="ywfO CDS" gene complement(3315806..3317107) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /label="ywfO gene" promotor_-10 complement(3317131..3317150) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3317145) /Source="Nicolas_upshifts" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3317147..3317268) /Source="Nicolas_S_feature" /locus_tag="new_3860876_3860997_c" /HighExp="G180, Paraq, Oxctl, G135, H2O2, G150, C30, LBGstat, LBGexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1456" promotor_-35 complement(3317166..3317168) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3317269..3317493) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391641.1" /db_xref="EnsemblGenomes-Gn:BSU37610" /db_xref="EnsemblGenomes-Tr:CAB15788" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR020880" /db_xref="SubtiList:BG14164" /db_xref="UniProtKB/Swiss-Prot:O32280" /translation="MANEFRVCDDCQATNIKTLLPRLKEVDPDAKVEVGCQSYCGPGR KKSFAFVNNRPLSAPTEDELIDKVKKKIKK*" /label="ywzC CDS" gene complement(3317269..3317493) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /label="ywzC gene" S_feature complement(3317494..3317578) /Source="Nicolas_S_feature" /locus_tag="new_3861223_3861307_c" /HighExp="G180, Paraq, H2O2, G135, LBGexp, dia15, G150, Lbexp, Heat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1457" promotor_-10 complement(3317567..3317586) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3317577) /Source="Nicolas_upshifts" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3317601..3317604) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3317644..3317650 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3317665..3317676 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3317666 /Source="Nicolas_upshifts" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="upshifts" CDS 3317708..3318484 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10629188, 16497325, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629188, 16497325, 22829778; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="prespore-specific transcription regulatory gene" /protein_id="NP_391642.1" /db_xref="EnsemblGenomes-Gn:BSU37620" /db_xref="EnsemblGenomes-Tr:CAB15789" /db_xref="GOA:P39650" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017877" /db_xref="SubtiList:BG10638" /db_xref="UniProtKB/Swiss-Prot:P39650" /translation="MTKQRQDAWSEENDLLLAETVLRHVREGSTQLNAFEEVGDKLNR TSAACGFRWNAVVRHQYEKALQLAKKQRKQRMRALGNGQPAKKRLLYQPPAVDPEIIQ ETAAEEPVKTETPSVENEQPLMSGEHMPFVDESFKEELASLSHLLSPQTPAAAPEMTM NDVIRFLQNYEGNHEQSSALKMENERLKKENQELQNKTEQLEAEVQKLEKDQKTIQED YETLVKIMNRARKLVLFEEDEHASPSFKMDRNGNLEKLAE*" /label="psrF CDS" gene 3317708..3318484 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /label="psrF gene" downshifts 3318470 /Source="Nicolas_upshifts" /id="D1951" /incds=0 /nref=14 /ntot=78 /MaxReadThrough="4.08166" /MaxDrop="4.36214" /score="-5.88286948" /energy="-14.4" /TU="U2958" /idTUdmin="U2958" /TUdmin="-3036" /isTUend="FALSE" /label="downshifts" promotor_-35 3318572..3318579 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3318594..3318613 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3318598..3322824 /Source="Nicolas_S_feature" /locus_tag="new_3862327_3866553" /HighExp="T1.30H, T2.0H, T1.0H, T2.30H, T0.30H, T3.0H, T3.30H, T4.0H, T5.0H, T0.0H" /AntisenseName="pta" /AntisenseCor="-0.61235087907102503" /AntisenseRegPval="-28.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.836" /TUlongSig="NA" /TUlongPSig="NA" /label="S1458" upshifts 3318598 /Source="Nicolas_upshifts" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3318628..3319518) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative toxic excess metabolite exporter" /protein_id="NP_391643.1" /db_xref="EnsemblGenomes-Gn:BSU37630" /db_xref="EnsemblGenomes-Tr:CAB15790" /db_xref="GOA:P39649" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004779" /db_xref="SubtiList:BG10637" /db_xref="UniProtKB/Swiss-Prot:P39649" /translation="MKGNIYSLFVLIAAFFWGTTGTVQALAPESATPLAFGAFRLLIG GSAMLLAVWISRELHVKNWAWPLVFLAAVCMACYQPLFFTAVKETGIAVGTVIAIGSA PIIAGTLEWAVLKKRPRNSWWIATVLALAGCWLLFSDSSNVRIDVAGVLMALGAGASF AGYTLISKAMMKTQPPRATSAVVFMISAILLTPLLWQLDISWILTPRGLGTSLYIGLI ATCAAYFLFAKGLTGVPASAAVTLSLAEPLTASLLGVFFIGEMLSPSSWLGIALMMLG LLVISAAPRKQKTAEAAHMS*" /label="ywfM CDS" gene complement(3318628..3319518) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /label="ywfM gene" promotor_no_box complement(3319518..3319618) /Source="Nicolas_upshift_promotors" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3319558) /Source="Nicolas_upshifts" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3319686..3320531) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /function="4: Biosynthesis of cofactors, prosthetic groups, and carriers" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidotransferase of the octanoyl moiety from octanoyl-GcvH to the E2 subunit of pyruvate dehydrogenase" /protein_id="NP_391644.1" /db_xref="EnsemblGenomes-Gn:BSU37640" /db_xref="EnsemblGenomes-Tr:CAB15791" /db_xref="GOA:P39648" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024897" /db_xref="SubtiList:BG10636" /db_xref="UniProtKB/Swiss-Prot:P39648" /translation="MANQPIDLLMQPKWRVIDQSSLGPLFDAKQSFAMDDTLCMSVGK GVSPATARSWVHHDTIVLGIQDTRLPFLQDGISLLESEGYRVIVRNSGGLAVVLDDGV LNISLIFEDEKKGIDIDKGYEAMVELMRRMLRPYNAKIEAYEIEGSYCPGSYDLSING KKFAGISQRRVRGGVAVQIYLCADKSGSERADLIRRFYQAALKDKQNDKKGVYPEIRP ETMASLSELLQKDISVQDLMFALLTELKALSTHLYSAGLSIDEEMEFEKNLVRMAERN AKVFG*" /label="lipL CDS" gene complement(3319686..3320531) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /label="lipL gene" downshifts complement(3319849) /Source="Nicolas_upshifts" /id="D1952" /incds=1 /nref=4 /ntot=180 /MaxReadThrough="3.21908" /MaxDrop="3.30122" /score="31.9003746" /energy="-18.6" /TU="U2961" /idTUdmin="U2961" /TUdmin="-27" /isTUend="FALSE" /label="downshifts" CDS complement(3320580..3321479) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sulfur assimilation CysL, activatescysJI expression" /protein_id="NP_391645.1" /db_xref="EnsemblGenomes-Gn:BSU37650" /db_xref="EnsemblGenomes-Tr:CAB15792" /db_xref="GOA:P39647" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10635" /db_xref="UniProtKB/Swiss-Prot:P39647" /translation="MYYDVLKTFIAVVEEKNFTKAAEKLMISQPSVSLHIKNLEKEFQ TALLNRSPKHFTTTPTGDILYQRAKQMVFLYEQAKAEIYAHHHYVKGELKIAASFTIG EYILPPLLAQLQKLYPELNLDVMIGNTEEVSERVRMLQADIGLIEGHTNENELEIEPF MEDEMCIAAPNQHPLAGRKEISISDLQNEAWVTREKGSGTREYLDHVLSSNGLRPKSM FTISSNQGVKEAVINGMGLSVLSRSVLRKDLIHREISILHINNFSLKRKLSYIHSPLM ENTKNKEIFITMLKSNYQSQLLK*" /label="cysL CDS" gene complement(3320580..3321479) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /label="cysL gene" promotor_-10 complement(3321522..3321541) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3321525) /Source="Nicolas_upshifts" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3321555..3321562) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3321626) /Source="Nicolas_upshifts" /id="D1953" /incds=0 /nref=222 /ntot=251 /MaxReadThrough="1.96406" /MaxDrop="7.24606" /score="32.3178773" /energy="-17.3" /TU="NA" /idTUdmin="U2962" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3321626..3322597) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /EC_number="2.3.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphotransacetylase" /protein_id="NP_391646.1" /db_xref="EnsemblGenomes-Gn:BSU37660" /db_xref="EnsemblGenomes-Tr:CAB15793" /db_xref="GOA:P39646" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR004614" /db_xref="InterPro:IPR012147" /db_xref="PDB:1TD9" /db_xref="PDB:1XCO" /db_xref="SubtiList:BG10634" /db_xref="UniProtKB/Swiss-Prot:P39646" /translation="MADLFSTVQEKVAGKDVKIVFPEGLDERILEAVSKLAGNKVLNP IVIGNENEIQAKAKELNLTLGGVKIYDPHTYEGMEDLVQAFVERRKGKATEEQARKAL LDENYFGTMLVYKGLADGLVSGAAHSTADTVRPALQIIKTKEGVKKTSGVFIMARGEE QYVFADCAINIAPDSQDLAEIAIESANTAKMFDIEPRVAMLSFSTKGSAKSDETEKVA DAVKIAKEKAPELTLDGEFQFDAAFVPSVAEKKAPDSEIKGDANVFVFPSLEAGNIGY KIAQRLGNFEAVGPILQGLNMPVNDLSRGCNAEDVYNLALITAAQAL*" /label="pta CDS" gene complement(3321626..3322597) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /label="pta gene" promotor_-10 complement(3322632..3322651) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3322657) /Source="Nicolas_upshifts" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3322667..3322671) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3322745..3322756) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3322748) /Source="Nicolas_upshifts" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3322770..3322776) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3322819..3322838 /Source="Nicolas_upshift_promotors" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3322826 /Source="Nicolas_upshifts" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="upshifts" CDS 3322867..3323631 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /EC_number="4.1.-.-" /function="4.3: Heme, porphyrin, and cobalamin" /experiment="publication(s) with functional evidences, PMID:15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-coproporphyrin (coproheme) decarboxylase" /protein_id="NP_391647.3" /db_xref="EnsemblGenomes-Gn:BSU37670" /db_xref="EnsemblGenomes-Tr:CAB15794" /db_xref="GOA:P39645" /db_xref="InterPro:IPR010644" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR031332" /db_xref="SubtiList:BG10633" /db_xref="UniProtKB/Swiss-Prot:P39645" /translation="MSEQQMTNEAAKTLDGWYALHDFRTMDWASWKLLSSDERQSIIH EFTGLLEKWGVAQKEGKGSQTLYSIVGQKADFMLMILRPTMEELNQIELEFNKSRLAE FTIPAYSYVSVVELSNYLASGDGDPYENPHVRARLYPELPESKYVCFYPMDKRRSGND NWYMLSMEERRNLMRSHGLIGRSYAGKVKQIITGSVGFDDYEWGVTLFSDDVLQFKKL VYEMRFDEVSARYGEFGSFFVGNHLSLDTLPQFLYV*" /label="hemQ CDS" gene 3322867..3323631 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /label="hemQ gene" downshifts 3323618 /Source="Nicolas_upshifts" /id="D1954" /incds=0 /nref=155 /ntot=246 /MaxReadThrough="5.49286" /MaxDrop="6.26609" /score="19.319449" /energy="-14.5" /TU="U2964" /idTUdmin="U2959" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(3323638,3323645) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs11" N_region 3323639..3323644 /note="SacI site (GAGCTC)" /created_by="User" /label="IIG_Bs11" S_feature <3323645..3323697 /Source="Nicolas_S_feature" /locus_tag="new_3873771_3874382" /HighExp="Etha, Salt, Gly, Heat, C30, LPhT, HiTm, C90, S8, M/G" /AntisenseName="bacA" /AntisenseCor="9.8443047207874598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1459" CDS complement(3323647..3324885) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15609023, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391655.1" /db_xref="EnsemblGenomes-Gn:BSU37750" /db_xref="EnsemblGenomes-Tr:CAB15802" /db_xref="GOA:P39637" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10625" /db_xref="UniProtKB/Swiss-Prot:P39637" /translation="MNSNQNNDIKTKHHFPLLLALALTMGVFAAGSEELVISPLLPDL AKAFSSDVSVLALSISIYGVMIFIGAPLLVPLGDKYSRELSLLAGLMIFIIGTVICAL AQNIFFFFLGRALSGLAAGAFVPTAYAVVGDRVPYTYRGKVMGLIVSSWSLALIFGVP LGSFIGGVLHWRWTFWIFALMGVLVVLLILLEMRRHAQHKNSGKEEIEEPAGTFRDAL KVPRVPVYITITFCNMIGFYGMYSFLGTYLQDVFTGGNTAAGLFIMIYGIGFSMSVIT GKIADRIGKMRSLLIALGVISVLLACLPYAPASMFLLIASLFIWGLMQSLTVTLLSTI LSDCSERHRGKVMVFYSLASNLAVTLGSALMGPVYVAYGYAAVGLICAAITVLGFVLS VFAYKKYGKLEQKADQSLSQ*" /label="ywfA CDS" gene complement(3323647..3324885) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /label="ywfA gene" promotor_-10 complement(3324927..3324946) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3324939) /Source="Nicolas_upshifts" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3324958..3324965) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3325095..3326507) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7540694, 8113162, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="basic aminoacid permease" /protein_id="NP_391656.1" /db_xref="EnsemblGenomes-Gn:BSU37760" /db_xref="EnsemblGenomes-Tr:CAB15803" /db_xref="GOA:P39636" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10624" /db_xref="UniProtKB/Swiss-Prot:P39636" /translation="MQNHKNELQRSMKSRHLFMIALGGVIGTGLFLGSGFTISQAGPL GAIAAYIIGGFLMYLVMLCLGELAVAMPVAGSFQAYATKFLGQSTGFMIGWLYWFSWA NTVGLELTSAGILMQRWLPSVPIWIWCLVFGIVIFLINALSVRSFAEMEFWFSSIKVA AIILFIVIGGAAVFGLIDFKGGQETPFLSNFMTDRGLFPNGVLAVMFTLVMVNFSFQG TELVGIAAGESESPEKTLPKSIRNVIWRTLFFFVLAMFVLVAILPYKTAGVIESPFVA VLDQIGIPFSADIMNFVILTAILSVANSGLYAASRMMWSLSSNQMGPSFLTRLTKKGV PMNALLITLGISGCSLLTSVMAAETVYLWCISISGMVTVVAWMSICASQFFFRRRFLA EGGNVNDLEFRTPLYPLVPILGFCLYGCVLISLIFIPDQRIGLYCGVPIIIFCYAYYH LSIKKRINHETIEKKQTEAQ*" /label="rocC CDS" gene complement(3325095..3326507) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /label="rocC gene" downshifts complement(3325102) /Source="Nicolas_upshifts" /id="D1957" /incds=0 /nref=16 /ntot=112 /MaxReadThrough="1.06691" /MaxDrop="5.69562" /score="41.626335" /energy="-15.9" /TU="NA" /idTUdmin="U2971" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3326507..3328207) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8113162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase involved in arginine and ornithine utilization" /protein_id="NP_391657.1" /db_xref="EnsemblGenomes-Gn:BSU37770" /db_xref="EnsemblGenomes-Tr:CAB15804" /db_xref="GOA:P39635" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG10623" /db_xref="UniProtKB/Swiss-Prot:P39635" /translation="MQYTKISHMNPAERVEALTASLVSLSSVNGTVGEGTKADFIKEV ITSYPYFQENPSHVWEQAIPNDPYKRKNIFAFIKGHGESRNTVIYHAHLDTVGIEDFG PLKDIAFDCEKLAEYFSRYEFDQDVQRDAKSGEWMFGRGSVDMQSGIAVHLANLLHFS ENLETLPGNVLFMANPDEESQHSGILASISELNRLKKEKQLHYLAAINTDFITPLYDG DQTRYIYTGAAGKLLPCFYIYGREVHVGDTLAGIDPNFISSEITSRLHNNIHLAEKVE GELVLPPSCLYQRDNKESYNVQTAVSTSLYFNCFIYERTAKEMMDLLIEVTEEACRET EQKLSDYYEEYVKRANLPKKHLSWGIQVYSLEQYLEKLRNRGIDPEQCIEQTFKANEH LELRMRCFQAIEELQKLDPDQGAKVILFYAPPYLPHNYLKEDSARDQLLQHVIKEAAD KTAESTGETFVFKKFFPYLADGSFLSLHETDGEIDSFIRNFPGWNMIGTIPFKDIRKL NIPSINMGVYGKDGHKWTERVYKPYTFHVLPLLIQQTTVHLLQSYRMTITAKEPKGEG *" /label="rocB CDS" gene complement(3326507..3328207) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /label="rocB gene" misc_feature complement(3327176..3327192) /Source="Nicolas_upshift_promotors" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3327188) /Source="Nicolas_upshifts" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3328281..3329828) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11418582, 12634342, 8113162, 9383188, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-1-pyrroline-5 carboxylate dehydrogenase" /protein_id="NP_391658.1" /db_xref="EnsemblGenomes-Gn:BSU37780" /db_xref="EnsemblGenomes-Tr:CAB15805" /db_xref="GOA:P39634" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10622" /db_xref="UniProtKB/Swiss-Prot:P39634" /translation="MTVTYAHEPFTDFTEAKNKTAFGESLAFVNTQLGKHYPLVINGE KIETDRKIISINPANKEEIIGYASTADQELAEKAMQAALQAFDSWKKQRPEHRANILF KAAAILRRRKHEFSSYLVKEAGKPWKEADADTAEAIDFLEFYARQMLKLKEGAPVKSR AGEVNQYHYEALGVGIVISPFNFPLAIMAGTAVAAIVTGNTILLKPADAAPVVAAKFV EVMEEAGLPNGVLNYIPGDGAEIGDFLVEHPKTRFVSFTGSRAVGCRIYERAAKVQPG QKWLKRVIAEMGGKDTVLVDKDADLDLAASSIVYSAFGYSGQKCSAGSRAVIHQDVYD EVVEKAVALTKTLTVGNPEDPDTYMGPVIHEASYNKVMKYIEIGKSEGKLLAGGEGDD SKGYFIQPTIFADVDENARLMQEEIFGPVVAICKARDFDHMLEIANNTEYGLTGALLT KNRAHIERAREDFHVGNLYFNRGCTGAIVGYQPFGGFNMSGTDSKAGGPDYLILHMQA KTTSEAF*" /label="rocA CDS" gene complement(3328281..3329828) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /label="rocA gene" downshifts complement(3328288) /Source="Nicolas_upshifts" /id="D1958" /incds=0 /nref=4 /ntot=50 /MaxReadThrough="5.60027" /MaxDrop="3.5628" /score="41.626335" /energy="-15.9" /TU="U2971,U2972" /idTUdmin="U2973" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3329872) /Source="Nicolas_upshifts" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3329874..3330054) /Source="Nicolas_S_feature" /locus_tag="new_3880559_3880739_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1460" misc_feature complement(3329875..3329893) /Source="Nicolas_upshift_promotors" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3330055..3331329) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate dehydrogenase" /protein_id="NP_391659.2" /db_xref="EnsemblGenomes-Gn:BSU37790" /db_xref="EnsemblGenomes-Tr:CAB15806" /db_xref="GOA:P39633" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K92" /db_xref="SubtiList:BG10621" /db_xref="UniProtKB/Swiss-Prot:P39633" /translation="MSAKQVSKDEEKEALNLFLSTQTIIKEALRKLGYPGDMYELMKE PQRMLTVRIPVKMDNGSVKVFTGYRSQHNDAVGPTKGGVRFHPEVNEEEVKALSIWMT LKCGIANLPYGGGKGGIICDPRTMSFGELERLSRGYVRAISQIVGPTKDIPAPDVYTN SQIMAWMMDEYSRLREFDSPGFITGKPLVLGGSQGRETATAQGVTICIEEAVKKKGIK LQNARIIIQGFGNAGSFLAKFMHDAGAKVIGISDANGGLYNPDGLDIPYLLDKRDSFG MVTNLFTDVITNEELLEKDCDILVPAAISNQITAKNAHNIQASIVVEAANGPTTIDAT KILNERGVLLVPDILASAGGVTVSYFEWVQNNQGYYWSEEEVAEKLRSVMVSSFETIY QTAATHKVDMRLAAYMTGIRKSAEASRFRGWV*" /label="rocG CDS" gene complement(3330055..3331329) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /label="rocG gene" S_feature complement(3331330..3331412) /Source="Nicolas_S_feature" /locus_tag="new_3882015_3882097_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.83780600000000005" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1461" upshifts complement(3331412) /Source="Nicolas_upshifts" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3331425..3331443) /Source="Nicolas_upshift_promotors" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3331505) /Source="Nicolas_upshifts" /id="D1959" /incds=0 /nref=9 /ntot=144 /MaxReadThrough="4.82066" /MaxDrop="4.13762" /score="22.6949864" /energy="-11.4" /TU="U2973" /idTUdmin="U2977" /TUdmin=369 /isTUend="FALSE" /label="downshifts" CDS complement(3331506..3331970) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /experiment="publication(s) with functional evidences, PMID:15187182, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 28751732; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm protein, member of the processed secretome contributing to biofilm hydrophobicity" /protein_id="NP_391660.1" /db_xref="EnsemblGenomes-Gn:BSU37800" /db_xref="EnsemblGenomes-Tr:CAB15807" /db_xref="GOA:P39632" /db_xref="InterPro:IPR034650" /db_xref="PDB:5MKD" /db_xref="SubtiList:BG10620" /db_xref="UniProtKB/Swiss-Prot:P39632" /translation="MLKRTSFVSSLFISSAVLLSILLPSGQAHAQSASIEAKTVNSTK EWTISDIEVTYKPNAVLSLGAVEFQFPDGFHATTRDSVNGRTLKETQILNDGKTVRLP LTLDLLGASEFDLVMVRKTLPRAGTYTIKGDVVNGLGIGSFYAETQLVIDPR*" /label="bslB CDS" gene complement(3331506..3331970) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /label="bslB gene" S_feature complement(3331971..3332081) /Source="Nicolas_S_feature" /locus_tag="new_3882656_3882766_c" /HighExp="C90, S1, S0, MG 150, M9-tran, LPhT, BI, GM 150, Lbtran, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1462" promotor_-10 complement(3332063..3332082) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-10" upshifts complement(3332081) /Source="Nicolas_upshifts" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="upshifts" promotor_-35 complement(3332097..3332104) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-35" downshifts complement(3332292) /Source="Nicolas_upshifts" /id="D1960" /incds=0 /nref=32 /ntot=80 /MaxReadThrough="3.01999" /MaxDrop="4.92444" /score="6.35246869" /energy="-8.4" /TU="U2977" /idTUdmin="U2977" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(3332294..3332749) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /EC_number="5.1.3.13" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25239894; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-deoxyrhamnose-3,5-epimerase (cell surface and spore coat)" /protein_id="YP_054595.1" /db_xref="EnsemblGenomes-Gn:BSU37810" /db_xref="EnsemblGenomes-Tr:CAE01469" /db_xref="GOA:Q7WY56" /db_xref="InterPro:IPR000888" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG14195" /db_xref="UniProtKB/Swiss-Prot:Q7WY56" /translation="MIDGVKVKKLMKHSDDRGFFAELVRDDENLLEHFGQASWSKSYP GVIKAFHYHEKQDDLWFFPTGHAQVVLYDLREDSKTKGETDVYYMGEDNPMLLLIPKG VAHGYRVLGETPLTIIYFTTMSYNPDQPDEKRIPWDDETIGFNWNTEFR*" /label="spsL CDS" gene complement(3332294..3332749) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /label="spsL gene" misc_feature 3332384..3332403 /Source="Nicolas_upshift_promotors" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3332392 /Source="Nicolas_upshifts" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3332742..3333593) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /EC_number="1.1.1.133" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-dehydrorhamnose reductase" /protein_id="NP_391661.3" /db_xref="EnsemblGenomes-Gn:BSU37820" /db_xref="EnsemblGenomes-Tr:CAB15808" /db_xref="GOA:P39631" /db_xref="InterPro:IPR005913" /db_xref="InterPro:IPR029903" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10619" /db_xref="UniProtKB/Swiss-Prot:P39631" /translation="MTKVLVTGAGGQLGLELCRQLKQAGYEVIALTKKMMNIADQRSV RHSFGHYQPDIVVNSAAFTSVDQCEKELDKAYLINGIGAYYTALESTRIGAQYVHIST DYVFNGKGTQPYREDDPLDPKTIYGKSKRLGEELIRLTTKDSTIIRTSWVYGHGGSNF VETMLKLAETKQELRVVSDQIGSPTYTKDLAEAVIKLFSHPPGIYHVSNSGICSWYEF ATAIMEESGLETAILSVTTEEYGNKTPRPAYSVLSHRAIEEAGIRPRHWREALREYLQ ERSSACD*" /label="spsK CDS" gene complement(3332742..3333593) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /label="spsK gene" CDS complement(3333607..3334554) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /EC_number="4.2.1.46" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dTDP-glucose 4,6-dehydratase" /protein_id="NP_391662.1" /db_xref="EnsemblGenomes-Gn:BSU37830" /db_xref="EnsemblGenomes-Tr:CAB15809" /db_xref="GOA:P39630" /db_xref="InterPro:IPR005888" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10618" /db_xref="UniProtKB/Swiss-Prot:P39630" /translation="MAKSYLITGGAGFIGLTFTKLMLRETDARITVLDKLTYASHPEE MEKLKQNSRFRFVKGDISVQEDIDRAFDETYDGVIHFAAESHVDRSISQAEPFITTNV MGTYRLAEAVLKGKAKKLIHISTDEVYGDLKADDPAFTETTPLSPNNPYSASKASSDL LVLSYVKTHKLPAIITRCSNNYGPYQHSEKMIPTIIRHAKQGLPVPLYGDGLQIRDWL FAEDHCRAIKLILEKGTDGEVYNIGGGNERTNKELASVILKHLGCEELFAHVEDRKGH DRRYAINASKLKNELGWRQEVTFEEGIARTIQWYTDNDR*" /label="spsJ CDS" gene complement(3333607..3334554) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /label="spsJ gene" CDS complement(3334554..3335294) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /EC_number="2.7.7.24" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate thymidylyltransferase" /protein_id="NP_391663.1" /db_xref="EnsemblGenomes-Gn:BSU37840" /db_xref="EnsemblGenomes-Tr:CAB15810" /db_xref="GOA:P39629" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005907" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10617" /db_xref="UniProtKB/Swiss-Prot:P39629" /translation="MKGVILAGGNGSRLMPLTKAVNKHLLPVGPYPMIYWSIMKLQEA GIKDILLISQKEHMPQFYKLLGNGEELGVTITYQVQPAASGISDGLSYAKRFTKKESF ILLLGDNIFEDSLKPYTERFEQQGKGAKVLLKEVDDPERFGIAEIDEKNKRIRSIIEK PEQPPTNLCVTGIYMYDAEVFSYIEQISPSKRGELEITDVNNLYIENSQLTYDVLSGW WVDAGTHESLYLASQLVHQALRKGQDEK*" /label="spsI CDS" gene complement(3334554..3335294) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /label="spsI gene" promotor_-35 3335312..3335317 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3335318 /Source="Nicolas_upshifts" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3335319..3336338) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391664.1" /db_xref="EnsemblGenomes-Gn:BSU37850" /db_xref="EnsemblGenomes-Tr:CAB15811" /db_xref="GOA:P39627" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10615" /db_xref="UniProtKB/Swiss-Prot:P39627" /translation="MHVGIFADGGYEKGMGHVVRMKRLAEGLKQRCLITFYTNQDSEA FLHEEHWQVIVKPELQQHEFILREIKSKKLDLLLFDILGAPAELLKKIKTETDAKIVL FEEKNGKSIQYSDAVINGIYGDIRSRVYVQGNTRIYEGPDYLILHPAFQAAREDYTLK KDCRNILVALGGSDPKQLIFKVLAAADQVPDIKDKNMMFVMGSASPHQEAVRRRIEKK PQYKMIEQTNDMAGLMKQADAAIVAGGISLYEAICIGVPCLVLSQVEHQTATAKTFAD QGAALDLGLGELVPDETLIYQMSRIMSSYPLRLSLHKGGRPLVDGKGIIRVTAILQDL YEQEI*" /label="spsG CDS" gene complement(3335319..3336338) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /label="spsG gene" promotor_-10 3335332..3335350 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3336202..3336211 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3336224..3336239 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3336235 /Source="Nicolas_upshifts" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3336341..3337063) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391665.2" /db_xref="EnsemblGenomes-Gn:BSU37860" /db_xref="EnsemblGenomes-Tr:CAB15812" /db_xref="InterPro:IPR003329" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10614" /db_xref="UniProtKB/Swiss-Prot:P39626" /translation="MNDILFIIQARMGSTRLPGKVLRPLGSNRLLDILVHRVRQSAFY QKDRDNLVIATSDKETDDILEAHCIKQGFRVFRGSEERVLDRFVKVIEAVKPSVIIRL TGDNPFVDPELLDVMIQAHFDQGSDYTYILNAPLGICGEVVNANLLIDISRIQALEDQ YQEHVTLYIRNHPALYRVQFLEAPERFRAPQYRLTIDTKEDYESIKALYQKAGERPDV SASELITLLNRNPDAATEREAD*" /label="spsF CDS" gene complement(3336341..3337063) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /label="spsF gene" CDS complement(3337056..3338177) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /EC_number="2.5.-.-" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12597896, 15774001; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoenolpyruvate-sugar pyruvyltransferase" /protein_id="NP_391666.1" /db_xref="EnsemblGenomes-Gn:BSU37870" /db_xref="EnsemblGenomes-Tr:CAB15813" /db_xref="GOA:P39625" /db_xref="InterPro:IPR006190" /db_xref="InterPro:IPR013132" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR036732" /db_xref="PDB:1VLI" /db_xref="SubtiList:BG10613" /db_xref="UniProtKB/Swiss-Prot:P39625" /translation="MAAFQIANKTVGKDAPVFIIAEAGINHDGKLDQAFALIDAAAEA GADAVKFQMFQADRMYQKDPGLYKTAAGKDVSIFSLVQSMEMPAEWILPLLDYCREKQ VIFLSTVCDEGSADLLQSTSPSAFKIASYEINHLPLLKYVARLNRPMIFSTAGAEISD VHEAWRTIRAEGNNQIAIMHCVAKYPAPPEYSNLSVIPMLAAAFPEAVIGFSDHSEHP TEAPCAAVRLGAKLIEKHFTIDKNLPGADHSFALNPDELKEMVDGIRKTEAELKQGIT KPVSEKLLGSSYKTTTAIEGEIRNFAYRGIFTTAPIQKGEAFSEDNIAVLRPGQKPQG LHPRFFELLTSGVRAVRDIPADTGIVWDDILLKDSPFHE*" /label="spsE CDS" gene complement(3337056..3338177) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /label="spsE gene" CDS complement(3338177..3339046) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative TDP-glycosamine N-acetyltransferase" /protein_id="NP_391667.1" /db_xref="EnsemblGenomes-Gn:BSU37880" /db_xref="EnsemblGenomes-Tr:CAB15814" /db_xref="GOA:P39624" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10612" /db_xref="UniProtKB/Swiss-Prot:P39624" /translation="MYTVKENVSKEAIEEFLQSRKLTLDVPYQFSLGLFENSRLQGVL LYEDSLWESKVLQKKVMNVKLLAANSTGQLKRLFEAFYTVRQMDETDFIFVRVPAEDI GAAHVIQQQPSSYFVGSLLKLAMPPSFYDKTPPFFELGPPEPGDTEAICELARDSFTK SRYFQDPHLSRDAANEIFQEWTRNNLNGRAAVNIVAKHNGEVIGYLQGLSRDDECILD LMAVKPGFEGKRIAFHLLANLIEQPETQKHRTVTAGTQLHNVRAIRLYERMGFTAEQS YYYYHIWPGKEAK*" /label="spsD CDS" gene complement(3338177..3339046) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /label="spsD gene" CDS complement(3339047..3340216) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /EC_number="2.6.1.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14602648; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glutamine-dependent sugar transaminase" /protein_id="NP_391668.1" /db_xref="EnsemblGenomes-Gn:BSU37890" /db_xref="EnsemblGenomes-Tr:CAB15815" /db_xref="GOA:P39623" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10611" /db_xref="UniProtKB/Swiss-Prot:P39623" /translation="MVQKRNHFLPYSLPLIGKEEIQEVTETLESGWLSKGPKVQQFEK EFAAFVGAKHAVAVNSCTAALFLALKAKGIGPGDEVITSPLTFSSTANTIIHTGATPV FADIDENTLNIDPVKLEAAVTPRTKAVVPVHFGGQSCDMDAILAVAQNHGLFVLEDAA HAVYTTYKQRMIGSIGDATAFSFYATKNLATGEGGMLTTDDEELADKIRVLSLHGMSK AAWNRYSSNGSWYYEVESPGYKMNMFDLQAALGLHQLKRLDDMQKRREEIAGRYQTAF QQIPGLITPFVHDDGRHAWHLYVLQVDEKKAGVTRSEMITALKDEYNIGTSVHFIPVH IHPYYQKQFGYKEADFPNAMNYYKRTLSLPLYPSMSDDDVDDVIEAVRDIVKGAD*" /label="spsC CDS" gene complement(3339047..3340216) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /label="spsC gene" CDS complement(3340237..3341661) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22611084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP glycosyl/glycerophosphate transferase or transport" /protein_id="NP_391669.2" /db_xref="EnsemblGenomes-Gn:BSU37900" /db_xref="EnsemblGenomes-Tr:CAB15816" /db_xref="GOA:P39622" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10610" /db_xref="UniProtKB/Swiss-Prot:P39622" /translation="MSAYLSNYWVLYRKYVELFDKLRYKGIPLGLISNFYQYISPELR VMMEEEPELFGSVDQHIDEGQIQPFFEERIQNIVKTNDEPVKGKVILHFDYLRFSNEN YYQFDPEKTAVLARWSLPHYCDLPVISKREIADSCQKGDSKQYLETACSLLAPYDDHP AFGDQAFRDRLFKDIPLFIEAIDTVDALFEQEKISAVIVGTAEDIYSRVLALMCQRKG AVSICLQHGALMGDEAFIPVFTTYQAVFGAYEAEWFIRKGCKPEQILVTGHPRFDQIF NRTPMDMSIFYRKLAFQPTKKIVLIATQPFSEDFYSGVLQGLSDQKQLQIIIKPHPWE IGKNKLDLYHEAAKKHQACRVIKKELELYDLLPYVDAAVTQTSTVGLEAMLFQKPVLI GKSSGNRSYPYYESLGDFMFDQPDELAHTLVEVLRSPDVHQKAEEARLAFIAANYPVA ESTNALFAELKAKTGVDYRREDTE*" /label="spsB CDS" gene complement(3340237..3341661) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /label="spsB gene" CDS complement(3341666..3342436) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10350455, 11042447, 11733986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10350455, 11042447, 11733986; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat dTDP-glycosyltransferase" /protein_id="NP_391670.1" /db_xref="EnsemblGenomes-Gn:BSU37910" /db_xref="EnsemblGenomes-Tr:CAB15817" /db_xref="GOA:P39621" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PDB:1H7L" /db_xref="PDB:1H7Q" /db_xref="PDB:1QG8" /db_xref="PDB:1QGQ" /db_xref="PDB:1QGS" /db_xref="SubtiList:BG10609" /db_xref="UniProtKB/Swiss-Prot:P39621" /translation="MPKVSVIMTSYNKSDYVAKSISSILSQTFSDFELFIMDDNSNEE TLNVIRPFLNDNRVRFYQSDISGVKERTEKTRYAALINQAIEMAEGEYITYATDDNIY MPDRLLKMVRELDTHPEKAVIYSASKTYHLNENRDIVKETVRPAAQVTWNAPCAIDHC SVMHRYSVLEKVKEKFGSYWDESPAFYRIGDARFFWRVNHFYPFYPLDEELDLNYITD QSIHFQLFELEKNEFVRNLPPQRNCRELRESLKKLGMG*" /label="spsA CDS" gene complement(3341666..3342436) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /label="spsA gene" promotor_-10 complement(3342471..3342490) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3342485) /Source="Nicolas_upshifts" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3342504..3342513) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3342604..3342609 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3342625..3342643 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3342627..3342755 /Source="Nicolas_S_feature" /locus_tag="new_3893312_3893440" /HighExp="S5, S4, S3, S7, B36, S8, S6, B60, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1463" upshifts 3342627 /Source="Nicolas_upshifts" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="upshifts" CDS 3342756..3343301 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12644503, 15317760, 16936016, 16936016, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12644503, 15317760, 16936016, 16936016, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391671.1" /db_xref="EnsemblGenomes-Gn:BSU37920" /db_xref="EnsemblGenomes-Tr:CAB15818" /db_xref="GOA:P39620" /db_xref="InterPro:IPR014099" /db_xref="SubtiList:BG10608" /db_xref="UniProtKB/Swiss-Prot:P39620" /translation="MKPKKNQYQQMQAFDNMQGYQPQFGANPYPQQGQGSQMQTMGMQ PMMPMQQGQQGQQGQQGFGFPGQQQGGGFQIPSGPTPSGPGQSVPGMLPVEESYIENI LRLNRGKTATIYMTFENSKEWGSKIFRGVIEAAGRDHIIISDPKSGTRYLLLTIYLDY ITFDEEIAYTYPYSMASYSPR*" /label="gerQ CDS" gene 3342756..3343301 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /label="gerQ gene" downshifts 3343287 /Source="Nicolas_upshifts" /id="D1961" /incds=0 /nref=60 /ntot=77 /MaxReadThrough="1.98659" /MaxDrop="7.96105" /score="16.9179802" /energy="-11.7" /TU="NA" /idTUdmin="U2978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3343345..3343716) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15919996, 21810204; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391672.2" /db_xref="EnsemblGenomes-Gn:BSU37930" /db_xref="EnsemblGenomes-Tr:CAB15819" /db_xref="GOA:P39619" /db_xref="InterPro:IPR006696" /db_xref="SubtiList:BG10607" /db_xref="UniProtKB/Swiss-Prot:P39619" /translation="MKVFIILGAINALLAVGLGAFGAHGLEGKIPDKYLQVWHTGVQY HMYHALGLFVVAFLADKLSGIGSVTTAGWLMFAGIVLFSGSLYILSVTQISILGAITP LGGVAFIISWIMIVVAAVKYL*" /label="ywdK CDS" gene complement(3343345..3343716) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /label="ywdK gene" downshifts complement(3343363) /Source="Nicolas_upshifts" /id="D1962" /incds=0 /nref=134 /ntot=227 /MaxReadThrough="3.65585" /MaxDrop="4.84049" /score="15.105437" /energy="-11.7" /TU="NA" /idTUdmin="U2979" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3343778..3345100) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine/pyrimidine permease" /protein_id="NP_391673.2" /db_xref="EnsemblGenomes-Gn:BSU37940" /db_xref="EnsemblGenomes-Tr:CAB15820" /db_xref="GOA:P39618" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="SubtiList:BG10606" /db_xref="UniProtKB/Swiss-Prot:P39618" /translation="MKLVLGALQWTAFIIAAAIVVPVAVAQSFHLDHSDSARLIQSTF FVLGIAAVIQCLKGHRLPINESPAGLWWGVYTIYAGLTGTVFATYGDTLRGLQGALLV SAVCFFLLSVFKVIDRLAKLFTPVVTGVYLLLLVMQLSQPIIKGILGIGYRQDGVDGL VFGLALVVIAAAFIMTNSNIMFFKQYSILLALFGGWVLFAAAGAAKPIEMPDRLFQLP SLFPFGTPLFNSGLIITSIFITILLIVNMLASMKVVDIAMKKFSKQPDGKHHERHAGF AASFSHLLSGLTGAIAPVPISGAAGFIETTKMPSKKPFMLGSILVIVISVIPFFMNTF ASLPSPVGFAVNFVVFSAMGGLAFAEFDSYEKEESKRVRSIIGISLLTGVGIMFVPET ALKGLHPVFISLLSNGLVLGTLAAIAADQFQLWRRRKSDNLVSTENKH*" /label="ywdJ CDS" gene complement(3343778..3345100) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /label="ywdJ gene" CDS complement(3345120..3345437) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391674.3" /db_xref="EnsemblGenomes-Gn:BSU37950" /db_xref="EnsemblGenomes-Tr:CAB15821" /db_xref="InterPro:IPR035218" /db_xref="SubtiList:BG10605" /db_xref="UniProtKB/Swiss-Prot:P39617" /translation="MNIHISALIQKMEEELKKAKTAERDEELKRYVAVVRSLCDVVLD QPENASAPRIQPSVTPSPAAPPSTDQLMMEKMMGSAGLNKYRKQEKEKQEEDGNGESL FDF*" /label="ywdI CDS" gene complement(3345120..3345437) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /label="ywdI gene" promotor_-10 complement(3345466..3345485) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3345477) /Source="Nicolas_upshifts" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3345499..3345505) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3345540..3345547 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3345563..3345582 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3345566 /Source="Nicolas_upshifts" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="upshifts" CDS 3345605..3346975 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391675.2" /db_xref="EnsemblGenomes-Gn:BSU37960" /db_xref="EnsemblGenomes-Tr:CAB15822" /db_xref="GOA:P39616" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10604" /db_xref="UniProtKB/Swiss-Prot:P39616" /translation="MNSIPSIISKHKAYFAAGHTRPLESRLNILRKLKQAVRTHEADL IAALYQDLHKSEQEAYSTEIGIVLEEISFVMKRLRKWSKPKRVKTPLTHLGSKSIIIP EPYGTVLVIAPWNYPLQLALSPLIGAIAAGNTVVLKPSEYTPAVSAILSKLISSVFPT DYVAMAEGGPDVSTALLQQPFDYIFFTGSVAVGKIVMEAAAKQLIPVTLELGGKSPCI VHKDADIQLAAKRIVFGKFTNAGQTCIAPDYLFVHEDIKTKLTEEMKRAIREFYGPQP ERNPQYGKIVSERHYQRLLSFLNDGIPLTGGQSDPNHHKIAPTILEQVRDDSPVMQEE IFGPILPLFTYRNIGEVIEKVQSRPKPLALYLFTTNKEIERAVLGNLSFGGGCVNDTL MHVATPYLPFGGVGESGIGSYHGFDSFNTFTHKKSVVKQTNRFDFAFRYPSSKNGLRM IRKILK*" /label="ywdH CDS" gene 3345605..3346975 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /label="ywdH gene" CDS complement(3347000..3347677) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /EC_number="3.2.2.27" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1902430, 9776748, 10080896, 21542855, 22056936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1902430, 9776748, 10080896, 21542855, 22056936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil-DNA glycosylase" /protein_id="NP_391676.1" /db_xref="EnsemblGenomes-Gn:BSU37970" /db_xref="EnsemblGenomes-Tr:CAB15823" /db_xref="GOA:P39615" /db_xref="InterPro:IPR002043" /db_xref="InterPro:IPR005122" /db_xref="InterPro:IPR018085" /db_xref="InterPro:IPR036895" /db_xref="PDB:3ZOQ" /db_xref="PDB:3ZOR" /db_xref="SubtiList:BG10603" /db_xref="UniProtKB/Swiss-Prot:P39615" /translation="MKQLLQDSWWNQLKEEFEKPYYQELREMLKREYAEQTIYPDSRD IFNALHYTSYDDVKVVILGQDPYHGPGQAQGLSFSVKPGVKQPPSLKNIFLELQQDIG CSIPNHGSLVSWAKQGVLLLNTVLTVRRGQANSHKGKGWERLTDRIIDVLSERERPVI FILWGRHAQMKKERIDTSKHFIIESTHPSPFSARNGFFGSRPFSRANAYLEKMGEAPI DWCIKDL*" /label="ung CDS" gene complement(3347000..3347677) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /label="ung gene" downshifts complement(3347014) /Source="Nicolas_upshifts" /id="D1963" /incds=0 /nref=66 /ntot=224 /MaxReadThrough="2.25259" /MaxDrop="4.72154" /score="26.8023311" /energy="-9.1" /TU="NA" /idTUdmin="U2982" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3347504..3347523) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3347520) /Source="Nicolas_upshifts" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3347539..3347544) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3347691..3348497) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /EC_number="2.4.-.-" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9334165; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391677.1" /db_xref="EnsemblGenomes-Gn:BSU37980" /db_xref="EnsemblGenomes-Tr:CAB15824" /db_xref="GOA:P39614" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10602" /db_xref="UniProtKB/Swiss-Prot:P39614" /translation="MKISIVIVTYNRIPALCELLESISRQTLMPYEIIIVNDAGESVV PVKALYPELPIAVINLEKNSGHVAARNAGVKEASGDCIMLCDDDDFFTPGHIEKMAKE IETADFVHSDAEIVSFEEKNGTRYPVSRKLFAYTADYEDMRVFSTYVPSGSMYRRFLH DEIGYFDADVHNYWDWDFYLRAAKDYRVKRVPCASVIYAFSDAGDNQSADLGAKRKQY LDRLSEKHGLGELPTKNFAVLLEEPEMKRREAKSEMVWDGEPVYSRLHRS*" /label="ywdF CDS" gene complement(3347691..3348497) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /label="ywdF gene" promotor_-10 complement(3347990..3348008) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3348004) /Source="Nicolas_upshifts" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3348023..3348029) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3348526..3348545) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3348532) /Source="Nicolas_upshifts" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3348561..3348568) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3348587..3349120) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391678.1" /db_xref="EnsemblGenomes-Gn:BSU37990" /db_xref="EnsemblGenomes-Tr:CAB15825" /db_xref="GOA:P39613" /db_xref="SubtiList:BG10601" /db_xref="UniProtKB/Swiss-Prot:P39613" /translation="MRISSCLYGFVAHGAVFLFTGGCMLLAMAASLPFVFLLDRLPDV VFTAGAILTLLCSYAYVWFWAVRFAYNQKMRLFEVQLGSFVLLALMISLFLLDGSSMK DIMMNWDDAGCAFVPPAFTFLCLSYALVLLPVYQSKLWRLILPNGVRMKDIFHVFGDL MLIMVLLIGATLLFLSL*" /label="ywdE CDS" gene complement(3348587..3349120) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /label="ywdE gene" CDS complement(3349168..3349803) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391679.2" /db_xref="EnsemblGenomes-Gn:BSU38000" /db_xref="EnsemblGenomes-Tr:CAB15826" /db_xref="GOA:P39612" /db_xref="SubtiList:BG10600" /db_xref="UniProtKB/Swiss-Prot:P39612" /translation="MDKETYVSEIKSGLKGLPEGEAMIEEIESHIEHHLFRSFQEGKS EEEAMQTLLQAFGTPTDIVSSFKKIQPVTFRAFLMFHLFCNSALFAVGIAITIMHVWL ESPFVQAVWKGISVSVWLILAAYMIYWVLIGYQGVKEFGKRGEKLVLHTILISMVPNV IFMLVFLFNVIPAALFQSLLTPWFVGTCAFATLLFPLFGRMGCYIGRRQLV*" /label="ywdD CDS" gene complement(3349168..3349803) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /label="ywdD gene" CDS complement(3349796..3350134) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator, PadR family" /protein_id="YP_003097793.1" /db_xref="EnsemblGenomes-Gn:BSU38018" /db_xref="EnsemblGenomes-Tr:CAX52706" /db_xref="GOA:C0H3S6" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3S6" /translation="MLNRELVKGSTVILVLTLLNERPMYGYELVKEMGSRSGNELQMK EGTLYPSLHKLERQGYISSYWEKQEKGPDRKYYRITDEGKEVLAERTKEWSVFSAMMD RILKWSGQNG*" /label="ywzG CDS" gene complement(3349796..3350134) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /label="ywzG gene" promotor_-10 complement(3350156..3350175) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3350167) /Source="Nicolas_upshifts" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3350190..3350197) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3350218..3350221 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3350236..3350255 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3350236 /Source="Nicolas_upshifts" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="upshifts" CDS 3350278..3351093 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /EC_number="2.7.1.35" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14973012, 17012797" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14973012, 17012797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyridoxine, pyridoxal, and pyridoxamine kinase" /protein_id="NP_391681.1" /db_xref="EnsemblGenomes-Gn:BSU38020" /db_xref="EnsemblGenomes-Tr:CAB15828" /db_xref="GOA:P39610" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="PDB:2I5B" /db_xref="SubtiList:BG10598" /db_xref="UniProtKB/Swiss-Prot:P39610" /translation="MSMHKALTIAGSDSSGGAGIQADLKTFQEKNVYGMTALTVIVAM DPNNSWNHQVFPIDTDTIRAQLATITDGIGVDAMKTGMLPTVDIIELAAKTIKEKQLK NVVIDPVMVCKGANEVLYPEHAQALREQLAPLATVITPNLFEASQLSGMDELKTVDDM IEAAKKIHALGAQYVVITGGGKLKHEKAVDVLYDGETAEVLESEMIDTPYTHGAGCTF SAAVTAELAKGAEVKEAIYAAKEFITAAIKESFPLNQYVGPTKHSALRLNQQS*" /label="pdxK CDS" gene 3350278..3351093 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /label="pdxK gene" downshifts 3351072 /Source="Nicolas_upshifts" /id="D1964" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="2.56759" /MaxDrop="5.39956" /score="22.0760698" /energy="-18.1" /TU="NA" /idTUdmin="U2985" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3351148) /Source="Nicolas_upshifts" /id="D1965" /incds=0 /nref=20 /ntot=111 /MaxReadThrough="0.56945" /MaxDrop="6.81686" /score="39.7901804" /energy="-16.8" /TU="NA" /idTUdmin="U2987" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3351183..3351431) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391682.1" /db_xref="EnsemblGenomes-Gn:BSU38030" /db_xref="EnsemblGenomes-Tr:CAB15829" /db_xref="SubtiList:BG10597" /db_xref="UniProtKB/Swiss-Prot:P39609" /translation="MNIHEQKITPECLEKAANQVEDKREEYKDVLLQLKKMLGGTTPH SETAEILTRAYEQMKEYALFVQSIETFLRKSANNLKIK*" /label="ywdA CDS" gene complement(3351183..3351431) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /label="ywdA gene" downshifts complement(3351203) /Source="Nicolas_upshifts" /id="D1966" /incds=0 /nref=6 /ntot=123 /MaxReadThrough="6.75845" /MaxDrop="3.89221" /score="22.6408081" /energy="-10.8" /TU="U2987,U2988" /idTUdmin="U2986" /TUdmin=11 /isTUend="TRUE" /label="downshifts" upshifts complement(3351449) /Source="Nicolas_upshifts" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3351451..3351524) /Source="Nicolas_S_feature" /locus_tag="new_3902136_3902209_c" /HighExp="G150, Mt0, Diami, Lbexp, dia0, dia5, T0.30H, Oxctl, Etha, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.536, 0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1464" misc_feature complement(3351459..3351465) /Source="Nicolas_upshift_promotors" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3351525..3352964) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /EC_number="3.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3100393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sucrose-6-phosphate hydrolase" /protein_id="NP_391683.2" /db_xref="EnsemblGenomes-Gn:BSU38040" /db_xref="EnsemblGenomes-Tr:CAB15830" /db_xref="GOA:P07819" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR006232" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG10596" /db_xref="UniProtKB/Swiss-Prot:P07819" /translation="MTAHDQELRRRAYEEVEKKEPIANSDPHRQHFHIMPPVGLLNDP NGVIYWKGSYHVFFQWQPFQTGHGAKFWGHYTTQDVVNWKREEIALAPSDWFDKNGCY SGSAVTKDDRLYLFYTGNVRDQDGNRETYQCLAVSDDGLSFEKKGVVARLPEGYTAHF RDPKVWEHEGTWYMVIGAQTENLKGQAVLFASDNLTEWRFLGPITGAGFNGLDDFGYM WECPDLFSLQGSDVLIVSPQGLEADGFRYQNVYQSGYFVGRLDYNKPELKHGEFTELD QGFDFYAPQTLEDDQGRRILFAWMAVPDQDEGSHPTIDCHWIHCMTLPRQLTLSGQKL IQQPLPELKAMRRNEKKIHINMHGSSGALPVEKPERTEILLEDIHTESGFSISIRGTA TFSFHKDEGIVTLERKSFDGKRTEARHCRIKDLHTVHMFLDASSVEIFINNGEEVLSA RYFPFPGNHEVTASATGKSEMNVGIWTLM*" /label="sacA CDS" gene complement(3351525..3352964) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /label="sacA gene" CDS complement(3352961..3354346) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /EC_number="2.7.1.211" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1577686, 3122206, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 3122206, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) sucrose-specificenzyme IIBC component" /protein_id="NP_391684.3" /db_xref="EnsemblGenomes-Gn:BSU38050" /db_xref="EnsemblGenomes-Tr:CAB15831" /db_xref="GOA:P05306" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10595" /db_xref="UniProtKB/Swiss-Prot:P05306" /translation="MDYKETAKRLIELLGGKENIISAAHCATRLRLVMKDESKIDQAQ VEELDGVKGAFSSSGQYQIIFGTGLVNKVFDAFSKEADIEREEHVNHQDAAKEKLNPA ARFAKTLSNIFVPIIPAIVASGLLMGLLGMINAFHWMSKDSALLQLLDMFSSAAFIFL PILIGVSASKEFGSNPYLGAVIGGIMIHPNLLNPWGLAEATPDYMHLFGFDIALLGYQ GTVIPVLLAVYVMSKVEKWTRKVVPHAVDLLVTPFVTVIVTGFVAFIAIGPLGRALGS GITVALTYVYDHAGFVAGLIFGGTYSLIVLTGVHHSFHAIEAGLIADIGKNYLLPIWS MANVAQGGAGLAVFFMAKKAKTKEIALPAAFSAFLGITEPVIFGVNLRYRKPFIAAMI GGALGGAYVVFTHVAANAYGLTGIPMIAIAAPFGFSNLIHYLIGMAIAAVSAFIAAFV MKINEDEERKK*" /label="sacP CDS" gene complement(3352961..3354346) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /label="sacP gene" misc_feature complement(3354365..3354374) /Source="Nicolas_upshift_promotors" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3354379) /Source="Nicolas_upshifts" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3354381..3354445) /Source="Nicolas_S_feature" /locus_tag="new_3905066_3905130_c" /HighExp="Diami, G150, dia5, Mt0, M9-stat, Lbtran, Gly, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1465" promotor_-10 complement(3354424..3354441) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3354445) /Source="Nicolas_upshifts" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3354457..3354464) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3354487..3354506) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3354505) /Source="Nicolas_upshifts" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3354520..3354527) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3354586..3354589 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3354596 /Source="Nicolas_upshifts" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3354604..3354623 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3354648..3355418 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16207915, 16428414, 16850406, 18691156; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite transporter" /protein_id="NP_391685.1" /db_xref="EnsemblGenomes-Gn:BSU38060" /db_xref="EnsemblGenomes-Tr:CAB15832" /db_xref="GOA:P39608" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG10594" /db_xref="UniProtKB/Swiss-Prot:P39608" /translation="METQALQKVEQYALKKQNIFASSKIRYVLRSILASIFIGFGITA ASKTGSYFFMADSPFAFPAAAVTFGAAILMIAYGGGDLFTGNTFYFTYTALRKKISWR DTLYLWMSSYAGNLIGAILFAILISATGLFEEPSVHSFLIHLAEHKMEPPASELFFRG MLCNWLVCLAFFIPMSLKGEGAKLFTMMLFVFCFFISGFEHSIANMCTFAISLLIEHP DTVTLMGAVRNLIPVTLGNLTAGIVMMGWMYYTLNPDQ*" /label="nirC CDS" gene 3354648..3355418 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /label="nirC gene" S_feature 3355419..3356486 /Source="Nicolas_S_feature" /locus_tag="new_3906104_3907171" /HighExp="S0, ferm, M0t45, Lbexp, Mal, dia0, M/G, UNK1, M40t45, BI" /AntisenseName="sacT" /AntisenseCor="-0.34218080984654098" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1466" CDS complement(3355457..3356287) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1577686, 2163394, 8535520, 8702561, 19202299, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 2163394, 8535520, 8702561, 19202299, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator of sacAP expression" /protein_id="NP_391686.1" /db_xref="EnsemblGenomes-Gn:BSU38070" /db_xref="EnsemblGenomes-Tr:CAB15833" /db_xref="GOA:P26212" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="SubtiList:BG10593" /db_xref="UniProtKB/Swiss-Prot:P26212" /translation="MKIYKVLNNNAALIKEDDQEKIVMGPGIAFQKKKNDLIPMNKVE KIFVVRDENEKFKQILQTLPEEHIEIAEDIISYAEGELAAPLSDHIHIALSDHLSFAI ERIQNGLLVQNKLLHEIKALYKKEYEIGLWAIGHVKETLGVSLPEDEAGYIALHIHTA KMDAESMYSALKHTTMIKEMIEKIKQYFNRKVDENSISYQRLVTHLRYAVSRLESNEA LHRMDEEMLYFIQKKYSFAYQCALELAEFLKNEYQLHLPESEAGYITLHVQRLQDLSE *" /label="sacT CDS" gene complement(3355457..3356287) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /label="sacT gene" downshifts complement(3355458) /Source="Nicolas_upshifts" /id="D1967" /incds=0 /nref=49 /ntot=139 /MaxReadThrough="3.34691" /MaxDrop="4.9787" /score="11.2756812" /energy="-8.1" /TU="U2992" /idTUdmin="U2991" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3356313..3356332) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3356319) /Source="Nicolas_upshifts" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3356327..3356629) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391687.2" /db_xref="EnsemblGenomes-Gn:BSU38080" /db_xref="EnsemblGenomes-Tr:CAB15834" /db_xref="SubtiList:BG10592" /db_xref="UniProtKB/Swiss-Prot:P39607" /translation="MKRLLVSLRVWMVFLMNWVTPDRKTAAAAVYSAQRTYQRKAAVQ AAGLVSFYEWRMAVNEEEKQKAKAAALYKRRCLQAFKESPKQERAGPHLYMAVKRR*" /label="ywcI CDS" gene complement(3356327..3356629) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /label="ywcI gene" promotor_-35 complement(3356347..3356354) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3356630..3356768) /Source="Nicolas_S_feature" /locus_tag="new_3907315_3907453_c" /HighExp="T5.0H, M9-stat, S2, S4, T4.0H, S3, T3.30H, LoTm, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.823" /TUlongSig="NA" /TUlongPSig="NA" /label="S1467" misc_feature complement(3356753..3356772) /Source="Nicolas_upshift_promotors" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3356768) /Source="Nicolas_upshifts" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3357083..3357091 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3357102..3357120 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3357103 /Source="Nicolas_upshifts" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="upshifts" CDS 3357159..3359579 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15205417, 15596354, 16946274, 17666034, 18689487, 25666135" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15205417, 15596354, 16946274, 17666034, 18689487, 25666135; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391688.1" /db_xref="EnsemblGenomes-Gn:BSU38090" /db_xref="EnsemblGenomes-Tr:CAB15835" /db_xref="GOA:P29141" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR025965" /db_xref="InterPro:IPR034213" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10591" /db_xref="UniProtKB/Swiss-Prot:P29141" /translation="MKKGIIRFLLVSFVLFFALSTGITGVQAAPASSKTSADLEKAEV FGDIDMTTSKKTTVIVELKEKSLAEAKEAGESQSKSKLKTARTKAKNKAIKAVKNGKV NREYEQVFSGFSMKLPANEIPKLLAVKDVKAVYPNVTYKTDNMKDKDVTISEDAVSPQ MDDSAPYIGANDAWDLGYTGKGIKVAIIDTGVEYNHPDLKKNFGQYKGYDFVDNDYDP KETPTGDPRGEATDHGTHVAGTVAANGTIKGVAPDATLLAYRVLGPGGSGTTENVIAG VERAVQDGADVMNLSLGNSLNNPDWATSTALDWAMSEGVVAVTSNGNSGPNGWTVGSP GTSREAISVGATQLPLNEYAVTFGSYSSAKVMGYNKEDDVKALNNKEVELVEAGIGEA KDFEGKDLTGKVAVVKRGSIAFVDKADNAKKAGAIGMVVYNNLSGEIEANVPGMSVPT IKLSLEDGEKLVSALKAGETKTTFKLTVSKALGEQVADFSSRGPVMDTWMIKPDISAP GVNIVSTIPTHDPDHPYGYGSKQGTSMASPHIAGAVAVIKQAKPKWSVEQIKAAIMNT AVTLKDSDGEVYPHNAQGAGSARIMNAIKADSLVSPGSYSYGTFLKENGNETKNETFT IENQSSIRKSYTLEYSFNGSGISTSGTSRVVIPAHQTGKATAKVKVNTKKTKAGTYEG TVIVREGGKTVAKVPTLLIVKEPDYPRVTSVSVSEGSVQGTYQIETYLPAGAEELAFL VYDSNLDFAGQAGIYKNQDKGYQYFDWDGTINGGTKLPAGEYYLLAYAANKGKSSQVL TEEPFTVE*" /label="vpr CDS" gene 3357159..3359579 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" /label="vpr gene" upshifts 3357317 /Source="Nicolas_upshifts" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3357326..3357345 /Source="Nicolas_upshift_promotors" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3359567 /Source="Nicolas_upshifts" /id="D1968" /incds=0 /nref=7 /ntot=104 /MaxReadThrough="0.60305" /MaxDrop="5.33856" /score="26.8487936" /energy="-16.5" /TU="NA" /idTUdmin="U2993" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(3359617..3360618) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913069, 15774866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391689.1" /db_xref="EnsemblGenomes-Gn:BSU38100" /db_xref="EnsemblGenomes-Tr:CAB15836" /db_xref="GOA:P39606" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10590" /db_xref="UniProtKB/Swiss-Prot:P39606" /translation="MVSLSILDQSPVSEGSNAETALQQTVALAQAAEDLGYKRFWVSE HHFSKRLAGSSPEVLISHIAAKTKRIRVGSGGVMLPHYSAYKVAENFRVLEGLTPGRI DLGLGRAPGGMPIASWALNDGGKRNADQYPQQIKELTMYLHDLADDKHRFPNLTAAPH ISTAPDVWLLGSSGESALLAAESGAGYMFAHFINGEGGEGTVRQYKRRFKPSVLGDTP RAAVAVFVLCADTEEKAEELGAVLDFTLLAGEQGIPLEGVPSYEAVRKNTYSPYEQRR IADNRNRMIVGTKEQVKERLLALSNAYETEEIMVVTITHHFEDKLRSYRLLQEAFAD* " /label="ywcH CDS" gene complement(3359617..3360618) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /label="ywcH gene" S_feature complement(3360619..3360780) /Source="Nicolas_S_feature" /locus_tag="new_3911304_3911465_c" /HighExp="Etha, Diami, dia15, LPhT, dia5, H2O2, B60, LBGstat, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1468" CDS complement(3360792..3361541) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /EC_number="1.5.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-containing NADPH-linked nitro/flavin reductase" /protein_id="NP_391690.1" /db_xref="EnsemblGenomes-Gn:BSU38110" /db_xref="EnsemblGenomes-Tr:CAB15837" /db_xref="GOA:P39605" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:3N2S" /db_xref="SubtiList:BG10589" /db_xref="UniProtKB/Swiss-Prot:P39605" /translation="MNNTIETILNHRSIRSFTDQLLTAEEIDTLVKSAQAASTSSYVQ AYSIIGVSDPEKKRELSVLAGNQPYVEKNGHFFVFCADLYRHQQLAEEKGEHISELLE NTEMFMVSLIDAALAAQNMSIAAESMGLGICYIGGIRNELDKVTEVLQTPDHVLPLFG LAVGHPANLSGKKPRLPKQAVYHENTYNVNTDDFRHTMNTYDKTISDYYRERTNGKRE ETWSDQILNFMKQKPRTYLNDYVKEKGFNKN*" /label="nfrAA CDS" gene complement(3360792..3361541) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /label="nfrAA gene" downshifts complement(3360825) /Source="Nicolas_upshifts" /id="D1969" /incds=0 /nref=11 /ntot=191 /MaxReadThrough="5.92216" /MaxDrop="3.39651" /score="17.7447455" /energy="-9.9" /TU="U2995" /idTUdmin="U2996" /TUdmin=770 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3361559..3361578) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3361576) /Source="Nicolas_upshifts" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3361593..3361596) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3361647..3362828) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9622350, 15612918, 15849754, 16850406, 28085152" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 15612918, 15849754, 16850406, 28085152; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycosyltransferase involved in extension of thelateral walls of the cell" /protein_id="NP_391691.1" /db_xref="EnsemblGenomes-Gn:BSU38120" /db_xref="EnsemblGenomes-Tr:CAB15838" /db_xref="GOA:P39604" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10588" /db_xref="UniProtKB/Swiss-Prot:P39604" /translation="MSRYKKQQSPFYQGDLIFIFGVFFIISVVSIYAAGQFGQYGNTD WIQQIVFYLLGAVAITVLLYFDLEQLEKLSLYIFIIGILSLIILKISPESIAPVIKGA KSWFRIGRITIQPSEFMKVGLIMMLASVIGKANPKGVRTLRDDIHLLLKIAGVAVIPV GLILMQDAGTAGICMFIVLVMVFMSGINWKLIAIIAGSGILLISLILLVMINFPDVAK SVGIQDYQIKRVTSWVSASNETQEDSNDSWQVDQAIMAIGSGGILGNGISNLKVYVPE STTDFIFSIIGESFGFIGCAIVVIMFFFLIYRLVVLIDKIHPFNRFASFFCVGYTALI VIHTFQNIGMNIGIMPVTGIPLLFVSYGGSSTLSTLIGFGIVYNASVQLTKYRSYLFN S*" /label="rodA CDS" gene complement(3361647..3362828) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /label="rodA gene" downshifts complement(3361661) /Source="Nicolas_upshifts" /id="D1970" /incds=0 /nref=20 /ntot=124 /MaxReadThrough="3.38052" /MaxDrop="5.67563" /score="31.4805549" /energy="-13.3" /TU="U2996" /idTUdmin="U2996" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(3362829..3362960) /Source="Nicolas_S_feature" /locus_tag="new_3913514_3913645_c" /HighExp="Heat, T0.30H, H2O2, T1.0H, Salt, Paraq, T1.30H, LBGstat, Oxctl, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1469" promotor_-10 complement(3362954..3362969) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-10" upshifts complement(3362960) /Source="Nicolas_upshifts" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="upshifts" promotor_-35 complement(3362981..3362990) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-35" promotor_-35 3363195..3363202 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3363213..3363323 /Source="Nicolas_S_feature" /locus_tag="new_3913898_3914008" /HighExp="M9-stat, T0.30H, T1.30H, T1.0H, T4.0H, T2.30H, T3.30H, T3.0H, T5.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1470" promotor_-10 3363213..3363232 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3363213 /Source="Nicolas_upshifts" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="upshifts" CDS 3363324..3363587 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16159778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159778; Product type f: factor" /codon_start=1 /transl_table=11 /product="holin-like protein required for proper spore morphogenesis and germination" /protein_id="NP_391692.1" /db_xref="EnsemblGenomes-Gn:BSU38130" /db_xref="EnsemblGenomes-Tr:CAB15839" /db_xref="GOA:P39603" /db_xref="InterPro:IPR020185" /db_xref="SubtiList:BG10587" /db_xref="UniProtKB/Swiss-Prot:P39603" /translation="MMDMFFAYLLVASATPLFIWLDNKKVALSAIPPIILMWVFFFFY ATESLSPLGHTLMIILFAVNVIVAHIAAFIIYGLPYLRRKRSS*" /label="ywcE CDS" gene 3363324..3363587 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /label="ywcE gene" downshifts 3363477 /Source="Nicolas_upshifts" /id="D1971" /incds=1 /nref=1 /ntot=99 /MaxReadThrough="6.85004" /MaxDrop="2.5697" /score="27.9247684" /energy="-11.4" /TU="U2997" /idTUdmin="U2997" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3363593 /Source="Nicolas_upshifts" /id="D1972" /incds=0 /nref=7 /ntot=90 /MaxReadThrough="2.04756" /MaxDrop="6.52141" /score="27.9247684" /energy="-11.4" /TU="NA" /idTUdmin="U2997" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(3363630..3364004) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit IV)" /protein_id="NP_391693.1" /db_xref="EnsemblGenomes-Gn:BSU38140" /db_xref="EnsemblGenomes-Tr:CAB15840" /db_xref="GOA:P34959" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014250" /db_xref="SubtiList:BG10586" /db_xref="UniProtKB/Swiss-Prot:P34959" /translation="MANKSAEHSHFPWKHIVGFILSIVLTLLALWVAVYTDLSSSAKL WIIFGFAFIQAALQLLMFMHMTESENGTIQVGNTLFGFFGAIVIVLGSIWIFAAHYHH GDHMDGNPPGGAEHSEHSGHNE*" /label="qoxD CDS" gene complement(3363630..3364004) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /label="qoxD gene" downshifts complement(3363641) /Source="Nicolas_upshifts" /id="D1973" /incds=0 /nref=222 /ntot=267 /MaxReadThrough="2.42368" /MaxDrop="9.0593" /score="21.3154492" /energy="-11.4" /TU="NA" /idTUdmin="U3000" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3364006..3364620) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit III)" /protein_id="NP_391694.1" /db_xref="EnsemblGenomes-Gn:BSU38150" /db_xref="EnsemblGenomes-Tr:CAB15841" /db_xref="GOA:P34958" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR014246" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10585" /db_xref="UniProtKB/Swiss-Prot:P34958" /translation="MEHAEHGNSNAPMEYQSETGRLNILGFWIFLGAEIVLFSTLFAT FFVLKNRTAGGVLPDELFEVNLVMIMTFLLLISSFTCGIAVHEMRRGSLKGVVIWTII TLLLGAGFVGCEINEFVHYVHEGAALSTSAFWSGFFVLLGTHGTHVTIGIFWITGILI QLKKRGLTPQTSSKIFISSLYWHFLDVVWIFIFTGVYLMGLGGL*" /label="qoxC CDS" gene complement(3364006..3364620) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /label="qoxC gene" CDS complement(3364634..3366583) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit I)" /protein_id="NP_391695.1" /db_xref="EnsemblGenomes-Gn:BSU38160" /db_xref="EnsemblGenomes-Tr:CAB15842" /db_xref="GOA:P34956" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014233" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10584" /db_xref="UniProtKB/Swiss-Prot:P34956" /translation="MKFKWDEFFVTGDPLILGAQVSIALSTIAIIFVLTYFKKWKWLW SEWITTVDHKKLGIMYIISAVIMLFRGGVDGLMMRAQLALPNNSFLDSNHYNEIFTTH GTIMIIFMAMPFLIGLINVVVPLQIGARDVAFPYLNNLSFWTFFVGAMLFNISFVIGG SPNAGWTSYMPLASNDMSPGPGENYYLLGLQIAGIGTLMTGINFMVTILKMRTKGMTL MRMPMFTWTTLITMVIIVFAFPVLTVALALLSFDRLFGAHFFTLEAGGMPMLWANLFW IWGHPEVYIVILPAFGIFSEIISSFARKQLFGYKAMVGSIIAISVLSFLVWTHHFFTM GNSASVNSFFSITTMAISIPTGVKIFNWLFTMYKGRISFTTPMLWALAFIPNFVIGGV TGVMLAMAAADYQYHNTYFLVSHFHYVLIAGTVFACFAGFIFWYPKMFGHKLNERIGK WFFWIFMIGFNICFFPQYFLGLQGMPRRIYTYGPNDGWTTLNFISTVGAFMMGVGFLI LCYNIYYSFRYSTREISGDSWGVGRTLDWATSSAIPPHYNFAVLPEVKSQDAFLHMKE EKTELYPESKFKKIHMPSNSGRPFFMSVAFGLAGFGLVFEWYWMGVVGLIGVLLCMVL RSFEYDNGYYISVDEIKETERKISE*" /label="qoxB CDS" gene complement(3364634..3366583) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /label="qoxB gene" misc_feature 3365847..3365866 /Source="Nicolas_upshift_promotors" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3365853 /Source="Nicolas_upshifts" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3366277..3366377 /Source="Nicolas_upshift_promotors" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3366337 /Source="Nicolas_upshifts" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3366447 /Source="Nicolas_upshifts" /id="D1974" /incds=1 /nref=1 /ntot=73 /MaxReadThrough="3.07388" /MaxDrop="3.44223" /score="-7.14620582" /energy="-8.1" /TU="U2999" /idTUdmin="U2999" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" CDS complement(3366611..3367576) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 22720735, 26196462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit II)" /protein_id="NP_391696.2" /db_xref="EnsemblGenomes-Gn:BSU38170" /db_xref="EnsemblGenomes-Tr:CAB15843" /db_xref="GOA:P34957" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR006332" /db_xref="InterPro:IPR006333" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR034227" /db_xref="InterPro:IPR036257" /db_xref="SubtiList:BG10583" /db_xref="UniProtKB/Swiss-Prot:P34957" /translation="MIFLFRALKPLLVLALLTVVFVLGGCSNASVLDPKGPVAEQQSD LILLSIGFMLFIVGVVFVLFTIILVKYRDRKGKDNGSYNPEIHGNTFLEVVWTVIPIL IVIALSVPTVQTIYSLEKAPEATKDKEPLVVYATSVDWKWVFSYPEQDIETVNYLNIP VDRPILFKISSADSMASLWIPQLGGQKYAMAGMLMDQYLQADKVGTYEGRNANFTGEH FADQEFDVNAVTEKDFNSWVKKTQNEAPKLTKEKYDELMLPENVDELTFSSTHLKYVD HGQDAEYAMEARKRLGYQAVSPHSKTDPFENVKKNEFKKSDDTEE*" /label="qoxA CDS" gene complement(3366611..3367576) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /label="qoxA gene" S_feature complement(3367577..3367645) /Source="Nicolas_S_feature" /locus_tag="new_3918262_3918330_c" /HighExp="M0t90, M40t90, Lbtran, Lbstat, M40t45, S2, nit, ferm, LBGstat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="0.626, 1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1471" promotor_-10 complement(3367632..3367651) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3367645) /Source="Nicolas_upshifts" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3367647..3367832) /Source="Nicolas_S_feature" /locus_tag="new_3918332_3918517_c" /HighExp="LBGstat, Heat, G150, G135, LBGtran, G180, BMM, Salt, LBGexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1472" promotor_-35 complement(3367664..3367668) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3367763..3367768 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3367784..3367802 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3367789 /Source="Nicolas_upshifts" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3367823..3367842) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3367832) /Source="Nicolas_upshifts" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3367834..3367943) /Source="Nicolas_S_feature" /locus_tag="new_3918519_3918628_c" /HighExp="Heat, Salt, LBGstat, BMM, Oxctl, H2O2, MG 15, UNK1, MG-0.1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1473" promotor_-35 complement(3367857..3367861) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3367899 /Source="Nicolas_upshifts" /id="D1975" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.69533" /MaxDrop="4.01393" /score="13.5410442" /energy="-16.4" /TU="U3001" /idTUdmin="U3001" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3367928..3367947) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3367943) /Source="Nicolas_upshifts" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3367963..3367967) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3368021..3368039) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3368026..3368032 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3368038) /Source="Nicolas_upshifts" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3368047..3368065 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3368050 /Source="Nicolas_upshifts" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3368055..3368060) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3368092..3368337 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391697.2" /db_xref="EnsemblGenomes-Gn:BSU38180" /db_xref="EnsemblGenomes-Tr:CAB15844" /db_xref="GOA:O32282" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG14162" /db_xref="UniProtKB/Swiss-Prot:O32282" /translation="MSFLISLIVAIIIGWLGSLFVKGDMPGGIIGSMIAGLIGAWIGH GLLGTWGPHLAGFAIIPAVIGAAIVVFLVSLLTRKRG*" /label="ywzA CDS" gene 3368092..3368337 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /label="ywzA gene" downshifts 3368319 /Source="Nicolas_upshifts" /id="D1976" /incds=0 /nref=125 /ntot=189 /MaxReadThrough="2.63086" /MaxDrop="7.72876" /score="13.5410442" /energy="-16.4" /TU="NA" /idTUdmin="U3005" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3368408..3369949) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /EC_number="2.7.7.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917, 11790749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917, 11790749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactose-1-phosphate uridyltransferase" /protein_id="NP_391698.2" /db_xref="EnsemblGenomes-Gn:BSU38190" /db_xref="EnsemblGenomes-Tr:CAB15845" /db_xref="GOA:P39575" /db_xref="InterPro:IPR000766" /db_xref="InterPro:IPR005849" /db_xref="InterPro:IPR005850" /db_xref="InterPro:IPR023425" /db_xref="SubtiList:BG10582" /db_xref="UniProtKB/Swiss-Prot:P39575" /translation="MSIIEHLEQLLEYGLERKLISIWDREYTRNRLYEALGITHPEPN SSTSIKQSQSLPDLLAPIYKWAAETGRMEADTDTYRDLLSAKLMGCFVPAPSEVIRKF EETKALYGPKQATKEFYQYSEDVYYIRTDRIAKNVHWTVPTEYGELEMTINLSKPEKD PKAIAAAKEQEQTNYPMCLLCKENVGFEGSVNHPARQNHRIIPVILEDEQWFLQFSPY VYYPEHCIVLKGEHEPMEISKKTFERLLSFLGQYPHYFIGSNADLPIVGGSILSHDHF QGGAHDFPMARAEAEDVYELNDYPGVSLGLVKWPMSVLRLQGDEPGHVAEAADHIFRT WQTYSDEKAGIAAYTGDTPHNTVTPIARRRGDLYELDIVLRNNRTDEEHPLGIFHPHQ EVHHIKKENIGLIEVMGLAILPGRLQEEMKETAAALCSADPKTALEQNPLTAKHSEWA LRTMEKRTITKENVDLVIKEELGHVFARILEHAGVFKQTAEGKQAFRRFIDQLGAKPV KSLNR*" /label="galT CDS" gene complement(3368408..3369949) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /label="galT gene" downshifts complement(3368437) /Source="Nicolas_upshifts" /id="D1977" /incds=0 /nref=190 /ntot=254 /MaxReadThrough="0.3431" /MaxDrop="6.63153" /score="21.0691542" /energy="-14.7" /TU="NA" /idTUdmin="U3006" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3369953..3371125) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /EC_number="2.7.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactokinase" /protein_id="NP_391699.1" /db_xref="EnsemblGenomes-Gn:BSU38200" /db_xref="EnsemblGenomes-Tr:CAB15846" /db_xref="GOA:P39574" /db_xref="InterPro:IPR000705" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR006206" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR019539" /db_xref="InterPro:IPR019741" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022963" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10581" /db_xref="UniProtKB/Swiss-Prot:P39574" /translation="MREELKGIFASVFGEKEGLRFFFAPGRVNLIGEHTDYNGGHVFP CALTMGTYAAVAERNDGLVRMYSDNFRNAGIKECSLDDIRYQKEDDWANYPKGVIYEF QQRGYAVPHGFDIVFSGNIPNGAGLSSSASIELLMGVVLQSYFHPEVDALELVKMAQH AENHFIGVNCGIMDQFAIGMGKKHHAMLLNCDTLDYEYSKLNVSGLALVIANTNKKRT LADSSYNTRRQECNDALLDLKKGLDIAALGDIKPSDFDAHSSLIQNETNRRRAKHAVY ENHRAIKTAHMFKENNIDEIGQLMKESHLSLKDDYEVTCPELDELVFAAWDHEGVIGS RMTGAGFGGCTISIVKDEFVDDFIQKVGDRYQEKTGLRADFYVADIGEGARELKGE*" /label="galK CDS" gene complement(3369953..3371125) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /label="galK gene" promotor_-10 complement(3371143..3371161) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3371165) /Source="Nicolas_upshifts" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3371176..3371182) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3371206..3371589) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882654, 15849754, 16850406, 18192405; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall glycosylation protein" /protein_id="NP_391700.1" /db_xref="EnsemblGenomes-Gn:BSU38210" /db_xref="EnsemblGenomes-Tr:CAB15847" /db_xref="GOA:P39602" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG10580" /db_xref="UniProtKB/Swiss-Prot:P39602" /translation="MYIIMGVFTTIVNIASFYILVEIMNVDYKAATVAAWILSVLFAY ITNKLYVFQQKTHDLQSLLKELTAFFSVRVLSLGIDLGMMIILVGQFNTNETLAKILD NAVIVVVNYVASKWLVFKKTKEEGV*" /label="ywcD CDS" gene complement(3371206..3371589) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /label="ywcD gene" CDS complement(3371607..3372278) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of slrA (biofilm formation)" /protein_id="NP_391701.2" /db_xref="EnsemblGenomes-Gn:BSU38220" /db_xref="EnsemblGenomes-Tr:CAB15848" /db_xref="GOA:P39601" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10579" /db_xref="UniProtKB/Swiss-Prot:P39601" /translation="MKKNKFQIKREATFESFIDAGVNLLIDRAYDPVSVEDISRAAGY SKGAFYVHFVSKDDFLLYLLEKRQMKKKIIIGYLDQMERESVKSLTLDEAAKHAAELL YSYYINKPSWDITSFAMNMPTYKVLKKCKAYVRLYELWVEENVLYIKWLKERKLIDAC IDPEYTAKIICAVLDGIIKQSYVLGQPATFRSFLDALSVFFTLDREHERPRILKSFSE SEEHQ*" /label="slrC CDS" gene complement(3371607..3372278) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /label="slrC gene" promotor_-10 complement(3372300..3372319) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3372309) /Source="Nicolas_upshifts" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3372335..3372338) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3372419..3372422 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3372437..3372456 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3372446..3372633 /Source="Nicolas_S_feature" /locus_tag="new_3923131_3923318" /HighExp="T0.30H, T1.0H, Cold, T1.30H, HiOs, T-0.40H, T2.0H, T2.30H, T4.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1474" upshifts 3372446 /Source="Nicolas_upshifts" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="upshifts" CDS 3372634..3372792 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168, 26857544" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168, 26857544; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-repressor of SlrR" /protein_id="YP_003097794.1" /db_xref="EnsemblGenomes-Gn:BSU38229" /db_xref="EnsemblGenomes-Tr:CAX52707" /db_xref="GOA:P0C8M5" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="UniProtKB/Swiss-Prot:P0C8M5" /translation="MKTHVKKDLDKGWHMLIQEARSIGLGIHDVRQFLESETASRKKN HKKTVRQD*" /label="slrA CDS" gene 3372634..3372792 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /label="slrA gene" S_feature 3372793..3373177 /Source="Nicolas_S_feature" /locus_tag="new_3923478_3923862" /HighExp="T0.30H, Cold, T1.30H, T2.0H, T1.0H, HiOs, T2.30H, T3.0H, LBGstat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1475" promotor_-35 3373158..3373163 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3373179..3373197 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3373179 /Source="Nicolas_upshifts" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="upshifts" CDS 3373235..3373543 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of acetate transporter as a volatile signal for biofilm formation" /protein_id="NP_391702.1" /db_xref="EnsemblGenomes-Gn:BSU38230" /db_xref="EnsemblGenomes-Tr:CAB15849" /db_xref="GOA:P39600" /db_xref="InterPro:IPR007436" /db_xref="SubtiList:BG10578" /db_xref="UniProtKB/Swiss-Prot:P39600" /translation="MYKADYKQIAATPSFQAFLKQKRAFIVPSAIFFFVFYFSLPVLT SYFTFLNAPAIGAVSWAWLFAIAQFAMTWILSTVYSRRAAHFDKYVSALKEDLKGEQT *" /label="vbfB CDS" gene 3373235..3373543 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /label="vbfB gene" downshifts complement(3373321) /Source="Nicolas_upshifts" /id="D1978" /incds=1 /nref=3 /ntot=15 /MaxReadThrough="0.42282" /MaxDrop="5.4957" /score="10.1452497" /energy="-8.3" /TU="NA" /idTUdmin="U3010" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3373325..3373425) /Source="Nicolas_upshift_promotors" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3373365) /Source="Nicolas_upshifts" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3373540..3375081 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="acetate Na+-dependent symporter subunit involvedin volatile signal for biofilm formation" /protein_id="NP_391703.2" /db_xref="EnsemblGenomes-Gn:BSU38240" /db_xref="EnsemblGenomes-Tr:CAB15850" /db_xref="GOA:P39599" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG10577" /db_xref="UniProtKB/Swiss-Prot:P39599" /translation="MNMTAFLLFLAIVGLTLIITYFAAKRTKTTSEFYTAGGGLTGVQ NGLAIAGDYMSAASFLGIAGMIALYGFDGFFYSIGFLVAYLVVLYIVAEPLRNLGKYT MADMIAARFKEKKIRGVAALNTIAISTFYMIAQLVGAGALIKLLLGLDYTAAVLIVGV LMTIYVVFGGMIATSWVQIIKAVLLMAGTLVISIIVFSKFGFSLNTMFEQMKTATPLG ADFLNPGNKYKVPLETLSLNLALVLGTAGLPHILIRFYTVKDAKTARTSVVSATWIIG VFYIMTVFLGFGAAAFVGFDAITAADQAGNMAAPLLAKALGGDFLFAFVSAIAFATIL AVVTGLVLSAASAFAHDIYSQIIRKGEATEKEQMKAARWASVAVSVLSILLAIFAQSL NVAFLVALAFAVAASANLPLIVFTVFWKRFNASGALWGSLTGLISALVLVSMSPSVWD PAGGAIFTGDPLIPLSNPGIISIPLGFLGAWLGTVLSSDKTIDEDTFAEIQVKAHTGV HMEQE*" /label="vbfA CDS" gene 3373540..3375081 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /label="vbfA gene" downshifts 3375072 /Source="Nicolas_upshifts" /id="D1979" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="2.40129" /MaxDrop="4.15104" /score="2.66606932" /energy="-7.8" /TU="NA" /idTUdmin="U3009" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3375112..3375714) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reductase" /protein_id="NP_391704.1" /db_xref="EnsemblGenomes-Gn:BSU38250" /db_xref="EnsemblGenomes-Tr:CAB15851" /db_xref="GOA:P39598" /db_xref="InterPro:IPR001853" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10576" /db_xref="UniProtKB/Swiss-Prot:P39598" /translation="MTVHIKVYSDYVCPFCFVGKAAFEEAIKGKDVEVEWMPFELRPS PSPQLDPVNDPSKQYMWQTSIQPMAEKLGVEINFPNVSPHPYTDLAFEGFHFAKEYNK GHEYNTRVFQAFFQEDQNIGDIDILTKLAEEVGLDGASFKSALETRTYQDVQRQALKH AYEEADITAVPTFIIGDTVIPGAAGKDVFEKAISDEQKKK*" /label="ywbO CDS" gene complement(3375112..3375714) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /label="ywbO gene" downshifts complement(3375126) /Source="Nicolas_upshifts" /id="D1980" /incds=0 /nref=12 /ntot=123 /MaxReadThrough="1.89374" /MaxDrop="3.51247" /score="21.9354981" /energy="-7.8" /TU="NA" /idTUdmin="U3011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3375715..3375996) /Source="Nicolas_S_feature" /locus_tag="new_3926400_3926681_c" /HighExp="T1.0H, G135, G150, T1.30H, Lbexp, G180, Lbstat, dia5, LBGexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.984, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1476" CDS complement(3375997..3377247) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /EC_number="1.11.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxidase converting ferric iron into ferrous iron" /protein_id="NP_391705.1" /db_xref="EnsemblGenomes-Gn:BSU38260" /db_xref="EnsemblGenomes-Tr:CAB15852" /db_xref="GOA:P39597" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR006313" /db_xref="InterPro:IPR006314" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019546" /db_xref="SubtiList:BG10575" /db_xref="UniProtKB/Swiss-Prot:P39597" /translation="MSDEQKKPEQIHRRDILKWGAMAGAAVAIGASGLGGLAPLVQTA AKPSKKDEKEEEQIVPFYGKHQAGITTAHQTYVYFAALDVTAKDKSDIITLFRNWTSL TQMLTSGKKMSAEQRNQYLPPQDTGESADLSPSNLTVTFGFGPGFFEKDGKDRFGLKS KKPKHLAALPAMPNDNLDEKQGGGDICIQVCADDEQVAFHALRNLLNQAVGTCEVRFV NKGFLSGGKNGETPRNLFGFKDGTGNQSTKDDTLMNSIVWIQSGEPDWMTGGTYMAFR KIKMFLEVWDRSSLKDQEDTFGRRKSSGAPFGQKKETDPVKLNQIPSNSHVSLAKSTG KQILRRAFSYTEGLDPKTGYMDAGLLFISFQKNPDNQFIPMLKALSAKDALNEYTQTI GSALYACPGGCKKGEYIAQRLLES*" /label="efeB CDS" gene complement(3375997..3377247) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /label="efeB gene" downshifts complement(3376093) /Source="Nicolas_upshifts" /id="D1981" /incds=1 /nref=67 /ntot=232 /MaxReadThrough="5.0552" /MaxDrop="3.65898" /score="21.9354981" /energy="-7.8" /TU="U3011,U3012" /idTUdmin="U3011" /TUdmin="-967" /isTUend="FALSE" /label="downshifts" CDS complement(3377266..3378423) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipoprotein binding ferrous or ferric iron for transport" /protein_id="NP_391706.1" /db_xref="EnsemblGenomes-Gn:BSU38270" /db_xref="EnsemblGenomes-Tr:CAB15853" /db_xref="GOA:P39596" /db_xref="InterPro:IPR018976" /db_xref="InterPro:IPR034981" /db_xref="SubtiList:BG10574" /db_xref="UniProtKB/Swiss-Prot:P39596" /translation="MNFTKIAVSAGCILALCAGCGANDTSSTKEKASSEKSGVTKEIT ASVNKMETIISKLNDSVEKGDQKEIEKKGKELNSYWLSFENDIRSDYPFEYTEIEKHL QPIYTEAQKDKPDAGKIKTESESLKASLEDLTEAKKSGKKASDQLAKAADEYKGYVKE QSDQLVKATEAFTGAVKSGDIEKSKTLYAKARVYYERIEPIAESLGDLDPKIDAREND VEEGDKWTGFHKLEKAIWKDQDISGEKATADQLLKDVKELDGSIQSLKLTPEQIVAGA MELLNEAGISKITGEEERYSRIDLVDLMANVEGSEAVYQTVKSALVKDHSDLTEKLDT EFSEFEVLMAKYKTNDQSYTSYDKLSEKQIRELSTKLTTLSETMSKIANVL*" /label="efeM CDS" gene complement(3377266..3378423) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /label="efeM gene" misc_feature complement(3377339..3377358) /Source="Nicolas_upshift_promotors" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3377366) /Source="Nicolas_upshifts" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3378420..3379865) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrous ion permease" /protein_id="NP_391707.2" /db_xref="EnsemblGenomes-Gn:BSU38280" /db_xref="EnsemblGenomes-Tr:CAB15854" /db_xref="GOA:P39595" /db_xref="InterPro:IPR004923" /db_xref="SubtiList:BG10573" /db_xref="UniProtKB/Swiss-Prot:P39595" /translation="MARGLALILFSLLMVFGSAAHAEDDPIAALIQLNKQMIKSVKDG DMDSAQQTFDTFKAKWKKEEPSIKKENLSSHSEMDANIAMISLSFINQDARKLKTQLE ELASHLETYQQAVVLKKTSSGQSRASLTAYIQSLKDTKQFIEKKQLDEASSAIDNLVT SWLAVEGDVVSQSKEAYTTSEENLALMKAEIGSHPEKVSKQIDEMIQLLEPIASSSYS WWDAALIPVREGMEALLVIGALLTMTKKARVTRSSTWIWGGASAGMAVSLAAGIGVTV LFSSSVFGENNFLLGGVTGVLSAVMLLYVGVWLHRNASMDKWREKINIQKSQALKKRS LLSFALIAFLAVVREGLETVIFFIGLVGKLPLTELIGGTAAGLIVLVIVGVLMIKLGM RIPLKPFFLLSMAVVLYMCVKFLGTGVHSLQLAGILPSDAESWLPSVSVLGIYPSVYS TIPQMLILLFLLIALVSEAAKHFTNGKELTK*" /label="efeU CDS" gene complement(3378420..3379865) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /label="efeU gene" promotor_-10 complement(3379899..3379918) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3379909) /Source="Nicolas_upshifts" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3379932..3379939) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3380022..3380690) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /EC_number="2.5.1.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10382260, 16291685, 19888457, 22616866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-phosphate pyrophosphorylase (thiamine phosphate synthase)" /protein_id="NP_391708.1" /db_xref="EnsemblGenomes-Gn:BSU38290" /db_xref="EnsemblGenomes-Tr:CAB15855" /db_xref="GOA:P39594" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR034291" /db_xref="InterPro:IPR036206" /db_xref="PDB:1G4E" /db_xref="PDB:1G4P" /db_xref="PDB:1G4S" /db_xref="PDB:1G4T" /db_xref="PDB:1G67" /db_xref="PDB:1G69" /db_xref="PDB:1G6C" /db_xref="PDB:2TPS" /db_xref="PDB:3O15" /db_xref="PDB:3O16" /db_xref="SubtiList:BG10572" /db_xref="UniProtKB/Swiss-Prot:P39594" /translation="MTRISREMMKELLSVYFIMGSNNTKADPVTVVQKALKGGATLYQ FREKGGDALTGEARIKFAEKAQAACREAGVPFIVNDDVELALNLKADGIHIGQEDANA KEVRAAIGDMILGVSAHTMSEVKQAEEDGADYVGLGPIYPTETKKDTRAVQGVSLIEA VRRQGISIPIVGIGGITIDNAAPVIQAGADGVSMISAISQAEDPESAARKFREEIQTY KTGR*" /label="thiE CDS" gene complement(3380022..3380690) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /label="thiE gene" downshifts complement(3380031) /Source="Nicolas_upshifts" /id="D1982" /incds=0 /nref=44 /ntot=194 /MaxReadThrough="1.62789" /MaxDrop="4.13196" /score="10.8502035" /energy="-10" /TU="NA" /idTUdmin="U3013" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3380687..3381505) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /EC_number="2.7.1.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10382260, 16291685, 22938038, 28729425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10382260, 16291685, 22938038, 28729425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-(2-hydroxyethyl)-4-methylthiazole kinase" /protein_id="NP_391709.1" /db_xref="EnsemblGenomes-Gn:BSU38300" /db_xref="EnsemblGenomes-Tr:CAB15856" /db_xref="GOA:P39593" /db_xref="InterPro:IPR000417" /db_xref="InterPro:IPR029056" /db_xref="PDB:1C3Q" /db_xref="PDB:1EKK" /db_xref="PDB:1EKQ" /db_xref="PDB:1ESJ" /db_xref="PDB:1ESQ" /db_xref="SubtiList:BG10571" /db_xref="UniProtKB/Swiss-Prot:P39593" /translation="MDAQSAAKCLTAVRRHSPLVHSITNNVVTNFTANGLLALGASPV MAYAKEEVADMAKIAGALVLNIGTLSKESVEAMIIAGKSANEHGVPVILDPVGAGATP FRTESARDIIREVRLAAIRGNAAEIAHTVGVTDWLIKGVDAGEGGGDIIRLAQQAAQK LNTVIAITGEVDVIADTSHVYTLHNGHKLLTKVTGAGCLLTSVVGAFCAVEENPLFAA IAAISSYGVAAQLAAQQTADKGPGSFQIELLNKLSTVTEQDVQEWATIERVTVS*" /label="thiM CDS" gene complement(3380687..3381505) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /label="thiM gene" CDS complement(3381513..3382418) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23504016; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family, cidAB expression)" /protein_id="NP_391710.1" /db_xref="EnsemblGenomes-Gn:BSU38310" /db_xref="EnsemblGenomes-Tr:CAB15857" /db_xref="GOA:P39592" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10570" /db_xref="UniProtKB/Swiss-Prot:P39592" /translation="MDIRHLTYFLEVARLKSFTKASQSLYVSQPTISKMIKNLEEELG IELFYRNGRQVELTDAGHSMYVQAQEIIKSFQNLTSELNDIMEVKKGHVRIGLPPMIG SGFFPRVLGDFRENYPNVTFQLVEDGSIKVQEGVGDGSLDIGVVVLPANEDIFHSFTI VKETLMLVVHPSHRLADEKECQLRELKDEPFIFFREDFVLHNRIMTECIKAGFRPHII YETSQWDFISEMVSANLGIGLLPERICRGLDPEKVKVIPLVDPVIPWHLAIIWRKDRY LSFAARAWLEHTKSYLWDPKKDSKG*" /label="cidR CDS" gene complement(3381513..3382418) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /label="cidR gene" misc_feature complement(3382153..3382172) /Source="Nicolas_upshift_promotors" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3382164) /Source="Nicolas_upshifts" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3382459..3382478) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3382469..3382476 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3382480) /Source="Nicolas_upshifts" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" upshifts 3382488 /Source="Nicolas_upshifts" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3382490..3382509 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3382494..3382501) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3382524..3382910 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 22383849, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator of murein hydrolases" /protein_id="NP_391711.1" /db_xref="EnsemblGenomes-Gn:BSU38320" /db_xref="EnsemblGenomes-Tr:CAB15858" /db_xref="GOA:P39591" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023760" /db_xref="SubtiList:BG10569" /db_xref="UniProtKB/Swiss-Prot:P39591" /translation="MKKLLLTVIQIALLFIFARLINWVTALLHINIPGSIIGIVILFT LLHFNIIKLEWIELGAAWLLGELLLFFIPSAVGVIEYGDIMSKFGVSILLVVIISTFV VMVSTGTLTQLIAKRKEKKHTCSSEL*" /label="cidA CDS" gene 3382524..3382910 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /label="cidA gene" CDS 3382892..3383569 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator controlling activity of murein hydrolases" /protein_id="NP_391712.2" /db_xref="EnsemblGenomes-Gn:BSU38330" /db_xref="EnsemblGenomes-Tr:CAB15859" /db_xref="GOA:P39590" /db_xref="InterPro:IPR005261" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG10568" /db_xref="UniProtKB/Swiss-Prot:P39590" /translation="MFIGIVSLFLTVLVYLGAKKVYQRFPRVYTSPLLVTPAVLVGLL LLVNVPYESYNLGGGLLTDMLQPATVAFAIPLYKYFPVLKKYAVEIILNVAVGSCIAI ISTALIAKWLHLGTGLIDSLVPRSVTTPIAMNVSEMIGGMPAVTAVFVILTALLGTVI GPMVIRYFRIDNEIARGVLLGTSAHGAGTSKAFELSSVSGTISSVSMILAAIMTLCAA PFLLSFM*" /label="cidB CDS" gene 3382892..3383569 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /label="cidB gene" downshifts 3383541 /Source="Nicolas_upshifts" /id="D1983" /incds=0 /nref=13 /ntot=88 /MaxReadThrough="2.20109" /MaxDrop="4.23919" /score="27.0474383" /energy="-8" /TU="NA" /idTUdmin="U3015" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3383613..3383620 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3383631 /Source="Nicolas_upshifts" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3383634..3383653 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3383673..3384872 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar permease" /protein_id="NP_391713.1" /db_xref="EnsemblGenomes-Gn:BSU38340" /db_xref="EnsemblGenomes-Tr:CAB15860" /db_xref="GOA:P39589" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024989" /db_xref="InterPro:IPR026032" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10567" /db_xref="UniProtKB/Swiss-Prot:P39589" /translation="MHNLQVRRHYAALKGFYLFAFLGTGSIIPLLSMYLTKEQHLSGS QVGLIMSLGPIVMIFFQPFWGMLSDYTQKTKGLLAVCTSITGIIGLAYIAFDSFPLFI LIAACFAAFQSTIIPLSDSISLRYTQETNGNYGGIRLFGSLGFGVAVFAMGQVTNQLY PIHVIFIFGCAFLCIAAILASQVPGQQKTTKVNIRKGFRELISNKTFLIFMIITFTTF APNLANNTYFSLFLDKSGASLSAIGILFFIGVISEIPFMRFAQTFIDKMGLLNVIMLS GGVSLFRWALYFTAPSLWIIYATVFLQGVAIGLFIPAALQYVKKITPRHVEATALTMY AAIGNGFGNWFCTFAGGYIFDYVSIFAVYLLFGILSIAGFGLTLYLMKAEKNKHTLHQ PAVTFKP*" /label="ywbF CDS" gene 3383673..3384872 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /label="ywbF gene" CDS 3384906..3385103 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391714.1" /db_xref="EnsemblGenomes-Gn:BSU38350" /db_xref="EnsemblGenomes-Tr:CAB15861" /db_xref="InterPro:IPR019240" /db_xref="SubtiList:BG10566" /db_xref="UniProtKB/Swiss-Prot:P39588" /translation="MNGQERNSISKGLQVDIVLKADQKTGKLTRGTVKDILTKSNFHP HGIKVRLEDGRIGRDQQIVST*" /label="ywbE CDS" gene 3384906..3385103 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /label="ywbE gene" downshifts 3385082 /Source="Nicolas_upshifts" /id="D1984" /incds=0 /nref=15 /ntot=205 /MaxReadThrough="1.90583" /MaxDrop="4.20528" /score="21.8132292" /energy="-12.2" /TU="NA" /idTUdmin="U3016" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(3385138..3386328) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18786544, 18789337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="large subunit ribosomal RNA m5C1962 methyltransferase" /protein_id="NP_391715.1" /db_xref="EnsemblGenomes-Gn:BSU38360" /db_xref="EnsemblGenomes-Tr:CAB15862" /db_xref="GOA:P39587" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019614" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10565" /db_xref="UniProtKB/Swiss-Prot:P39587" /translation="MKLLTLKKAHAAKIKKGYPLIEKEALAGSAGHMKEGDLVDIVSE SGGEFLARGYYGLQNKGVGWTLTRNKHEQIDQAFFLSKLTKAAQARAKLFEAQDTTAF RLFNGEGDGVGGVTIDYYDGYLLIQWYSKGIYTFKDMLISALDEMDLDYKAIYEKKRF DTAGQYVEDDDFVKGRRGEFPIIIQENGIQYAVDLNEGAMTGIFLDQRHVRKAIRDRY AKGKTVLNTFSYTGAFSVAAALGGAEKTTSVDVANRSLAKTIEQFSVNKLDYEAHDIK VMDVFNYFSYAAKKDLRFDLIILDPPSFARTKKRTFSAAKDYKNLLKETIAITADKGV IVASTNSSAFGMKKFKGFIDAAFKETNERYTIIEEFTLPEDFKTISAFPEGNYLKVVL LQKK*" /label="rlmI CDS" gene complement(3385138..3386328) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /label="rlmI gene" downshifts complement(3385153) /Source="Nicolas_upshifts" /id="D1985" /incds=0 /nref=5 /ntot=127 /MaxReadThrough="0.0525399999999996" /MaxDrop="4.51664" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin=71 /isTUend="FALSE" /label="downshifts" downshifts complement(3385237) /Source="Nicolas_upshifts" /id="D1986" /incds=1 /nref=42 /ntot=233 /MaxReadThrough="2.99734" /MaxDrop="3.89369" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" misc_feature complement(3386352..3386371) /Source="Nicolas_upshift_promotors" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3386368) /Source="Nicolas_upshifts" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3386388..3386395 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3386404 /Source="Nicolas_upshifts" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3386409..3386428 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3386449..3386829 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24330391, 25283443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391, 25283443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase I; hemithioacetal-bacillithiol lactoyl-bacillithiol formation" /protein_id="NP_391716.1" /db_xref="EnsemblGenomes-Gn:BSU38370" /db_xref="EnsemblGenomes-Tr:CAB15863" /db_xref="GOA:P39586" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10564" /db_xref="UniProtKB/Swiss-Prot:P39586" /translation="MAKRIDHTGIMVRDINASITFYEEVLGMKLKDRITHTNGVIELA FLGFEDGPETEIELIQGYSSELPAEGKVHHIALLTDDIAAEYTKAEKMNAKFIDEEIT TLPNGYRYFYIEGPDGEWIEFFQR*" /label="glxA CDS" gene 3386449..3386829 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /label="glxA gene" downshifts 3386727 /Source="Nicolas_upshifts" /id="D1987" /incds=1 /nref=14 /ntot=215 /MaxReadThrough="3.76076" /MaxDrop="3.68951" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-357" /isTUend="FALSE" /label="downshifts" downshifts 3386798 /Source="Nicolas_upshifts" /id="D1988" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="3.05249" /MaxDrop="3.56101" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" CDS complement(3386867..3387544) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391717.1" /db_xref="EnsemblGenomes-Gn:BSU38380" /db_xref="EnsemblGenomes-Tr:CAB15864" /db_xref="InterPro:IPR024250" /db_xref="SubtiList:BG10563" /db_xref="UniProtKB/Swiss-Prot:P39585" /translation="MLDYIWLDDESPILQQVPVEYSSAALIFSPFIQMPEGWENAKRK NDYEHIYPNDNEIRGIGKAVSWKKVMSSCGFQTHAELALALMTSIGALRDEFAREDLA EVLHENINGDLYYPSEDHISNFHIPSLVKVLGANGSNRFYYAEPIVENRGVLDITEAN LRTVLDEAATELVLTDEKMDFVFMSVYDSFINVFLAKDKNIHELVERMGWEAMICDES TYISWYR*" /label="ywbB CDS" gene complement(3386867..3387544) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" /label="ywbB gene" downshifts complement(3386874) /Source="Nicolas_upshifts" /id="D1989" /incds=0 /nref=6 /ntot=156 /MaxReadThrough="0.15283" /MaxDrop="5.41362" /score="0.491291944" /energy="-11.7" /TU="NA" /idTUdmin="U3020" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3387553..3387572) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3387578) /Source="Nicolas_upshifts" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3387584..3387590) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3387621..3388955) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8990303, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cellobiose phosphotransferase system enzyme IIC permease component" /protein_id="NP_391718.1" /db_xref="EnsemblGenomes-Gn:BSU38390" /db_xref="EnsemblGenomes-Tr:CAB15865" /db_xref="GOA:P39584" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG10562" /db_xref="UniProtKB/Swiss-Prot:P39584" /translation="MSTFTRVMEEKIMPVAGKIAGQRHLSALRDGIILTMPLIIIGSV FLILTSLPIPGYADFMASVFGNEWADKLGYPVNASFDIMAMIAAFGIAYRLAESYGVD ALSAGAISIAAFLLATPFEVPFTPHGSTESIMVGGGIPITLLGSKGLFVAMLIALFST EIYRYIIQKNIVFKMPDGVPPAVSKSFVALIPGFIIVLLVWLARLLIEMTPFQSLHNV VGDLLGTPLSILGGSLGGSLIAEFVQMLLWSCGIHGASIIGGIMAPIWYGAMDANRLA FQAGEALPSIFTTQFFQIWINVGGSGATLALVLTMLVRSRSKQMKQLGRLGIGPALFN INEPIIFGMPIVMNPLLIVPFIIAPLLTITATYIGMSTGLVARPAGIAVPWTMPPLIS GYLATGGKVSGAVMQLVNLLITCAIYYPFFRIWDHQKWREESAVESGDKNVM*" /label="ywbA CDS" gene complement(3387621..3388955) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" /label="ywbA gene" misc_feature complement(3389003..3389021) /Source="Nicolas_upshift_promotors" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3389026) /Source="Nicolas_upshifts" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3389120..3389127 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3389132 /Source="Nicolas_upshifts" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3389141..3389159 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3389183..3391120 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391719.1" /db_xref="EnsemblGenomes-Gn:BSU38400" /db_xref="EnsemblGenomes-Tr:CAB15866" /db_xref="GOA:P16396" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10561" /db_xref="UniProtKB/Swiss-Prot:P16396" /translation="MKNMSCKLVVSVTLFFSFLTIGPLAHAQNSSEKEVIVVYKNKAG KETILDSDADVEQQYKHLPAVAVTADQETVKELKQDPDILYVENNVSFTAADSTDFKV LSDGTDTSDNFEQWNLEPIQVKQAWKAGLTGKNIKIAVIDSGISPHDDLSIAGGYSAV SYTSSYKDDNGHGTHVAGIIGAKHNGYGIDGIAPEAQIYAVKALDQNGSGDLQSLLQG IDWSIANRMDIVNMSLGTTSDSKILHDAVNKAYEQGVLLVAASGNDGNGKPVNYPAAY SSVVAVSATNEKNQLASFSTTGDEVEFSAPGTNITSTYLNQYYATGSGTSQATPHAAA MFALLKQRDPAETNVQLREEMRKNIVDLGTAGRDQQFGYGLIQYKAQATDSAYAAAEQ AVKKAEQTKAQIDINKARELISQLPNSDAKTALHKRLDKVQSYRNVKDAKDKVAKAEK YKTQQTVDTAQTAINKLPNGTDKKNLQKRLDQVKRYIASKQAKDKVAKAEKSKKKTDV DSAQSAIGKLPASSEKTSLQKRLNKVKSTNLKTAQQSVSAAEKKSTDANAAKAQSAVN QLQAGKDKTALQKRLDKVKKKVAAAEAKKVETAKAKVKKAEKDKTKKSKTSAQSAVNQ LKASNEKTKLQKRLNAVKPKK*" /label="epr CDS" gene 3389183..3391120 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" /label="epr gene" promotor_-10 complement(3390327..3390346) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3390328) /Source="Nicolas_upshifts" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3390360..3390368) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3391110 /Source="Nicolas_upshifts" /id="D1990" /incds=0 /nref=175 /ntot=224 /MaxReadThrough="1.26567" /MaxDrop="6.00181" /score="15.6173594" /energy="-13" /TU="NA" /idTUdmin="U3021" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3391223..3391230 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3391245..3391264 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3391264 /Source="Nicolas_upshifts" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3391476..3391483 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3391496..3391515 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3391496 /Source="Nicolas_upshifts" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="upshifts" CDS 3391548..3392927 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11580842, 1400159, 8535520, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11580842, 1400159, 8535520, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of SacY" /protein_id="NP_391720.1" /db_xref="EnsemblGenomes-Gn:BSU38410" /db_xref="EnsemblGenomes-Tr:CAB15867" /db_xref="GOA:P15400" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10560" /db_xref="UniProtKB/Swiss-Prot:P15400" /translation="MHKEIAKELLLLAGGKNNIISISHCTTRLRFDVKDETKIDIHAI ENLQGVQGTFFRYGLFQIIFGAGVVNKIYKEVVHVWETAPSEEPVHQKKASRKLNPAA AFAKTLSDIFVPIIPAITASGLLMGLIGMIKVFHWFAAGSPWIKMLDLVSSTAFILLP ILVGFSAARQFGSNPYLGAVIAGLLTHPDLLDPSMLGSKTPSSLDIWGLHIPMMGYQG SMIPILLSVFVMSKIEKLLKSIVPKSLDVVIIPFITVMVTGCLALIVMNPAASIIGQI MTQSIVYIYDHAGIAAGALFGGIYSTIVLSGLHHSFYAIEATLLANPHVGVNFLVPIW SMANVAQGGAGLAVFLKTKQSSLKKIALPASLTAFLGIVEPIVFGVNLKLIRPFIGAA IGGAIGGAYVVAVQVVANSYGLTGIPMISIVLPFGAANFVHYMIGFLIAAVSAFIATL FLGFKEETE*" /label="sacX CDS" gene 3391548..3392927 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /label="sacX gene" S_feature complement(3392636..3393839) /Source="Nicolas_S_feature" /locus_tag="new_3943322_3944525_c" /HighExp="Etha, B36, B60, M9-stat, Salt, Sw, LoTm, C30, Gly, Heat" /AntisenseName="sacY" /AntisenseCor="-0.177403958488455" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1477" CDS 3392981..3393823 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9305644, 9457872, 11580842, 12079345, 15528654, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9305644, 9457872, 11580842, 12079345, 15528654, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391721.1" /db_xref="EnsemblGenomes-Gn:BSU38420" /db_xref="EnsemblGenomes-Tr:CAB15868" /db_xref="GOA:P15401" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1AUU" /db_xref="SubtiList:BG10559" /db_xref="UniProtKB/Swiss-Prot:P15401" /translation="MKIKRILNHNAIVVKDQNEEKILLGAGIAFNKKKNDIVDPSKIE KTFIRKDTPDYKQFEEILETLPEDHIQISEQIISHAEKELNIKINERIHVAFSDHLSF AIERLSNGMVIKNPLLNEIKVLYPKEFQIGLWARALIKDKLGIHIPDDEIGNIAMHIH TARNNAGDMTQTLDITTMIRDIIEIIEIQLSINIVEDTISYERLVTHLRFAIQHIKAG ESIYELDAEMIDIIKEKFKDAFLCALSIGTFVKKEYGFEFPEKELCYIAMHIQRFYQR SVAR*" /label="sacY CDS" gene 3392981..3393823 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /label="sacY gene" CDS complement(3393874..3394734) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11377871, 19659723; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase (general stress protein)" /protein_id="NP_391722.1" /db_xref="EnsemblGenomes-Gn:BSU38430" /db_xref="EnsemblGenomes-Tr:CAB15869" /db_xref="GOA:P25148" /db_xref="InterPro:IPR002495" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10558" /db_xref="UniProtKB/Swiss-Prot:P25148" /translation="MRKDEIMHIVSCADDNYARHLGGMFVSLLTNMDQEREVKLYVID GGIKPDNKKRLEETTLKFGVPIEFLEVDTNMYEHAVESSHITKAAYYRISIPDLIKDE SIKRMIYIDCDALVLEDISKLWDLDIAPYTVAAVEDAGQHERLKEMNVTDTGKYFNSG IMIIDFESWRKQNITEKVINFINEHPDEDFLVLHDQDALNAILYDQWYELHPRWNAQT YIMLKLKTPSTLLGRKQYNETRENPAIVHFCGGEKPWNSNTKHPYRDEYFHYMSYTKW NTIGNPAINQ*" /label="gspA CDS" gene complement(3393874..3394734) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /label="gspA gene" downshifts complement(3393884) /Source="Nicolas_upshifts" /id="D1991" /incds=0 /nref=73 /ntot=227 /MaxReadThrough="5.61926" /MaxDrop="7.47527" /score="21.8603429" /energy="-10.6" /TU="U3025" /idTUdmin="U3025" /TUdmin="-1224" /isTUend="FALSE" /label="downshifts" downshifts 3394718 /Source="Nicolas_upshifts" /id="D1992" /incds=0 /nref=8 /ntot=30 /MaxReadThrough="1.49599" /MaxDrop="5.33818" /score="10.6843241" /energy="-4.5" /TU="NA" /idTUdmin="U3026" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3394756..3394774) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3394774) /Source="Nicolas_upshifts" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3394789..3394795) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3394844..3395557) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391723.1" /db_xref="EnsemblGenomes-Gn:BSU38440" /db_xref="EnsemblGenomes-Tr:CAB15870" /db_xref="GOA:P25149" /db_xref="InterPro:IPR011737" /db_xref="SubtiList:BG10557" /db_xref="UniProtKB/Swiss-Prot:P25149" /translation="MQKYVQSDYKHDPFHLFSTEHVVTLAIISLLAILLFLFQDEVKQ PRASRFLRSLFVFLLLGSQIGYQIWMVATDRWSVRTSLPLQLSDLSVYLSAIMLVTKS RKLFVFLFFVGIGSSIQALATPDLGMFSFPHIRYILFFISHGSVFLSCLLMAVIGTYR MGQRSLWVTVLLVNVYGVCIFLIDRWLGANYMYLTKKPGGSSLLDVLGPWPWYIVSAE AITIASFFILYWLYRIFKK*" /label="ywaF CDS" gene complement(3394844..3395557) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /label="ywaF gene" promotor_-35 3394959..3394960 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3394980..3394997 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3394982 /Source="Nicolas_upshifts" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3395585..3395596) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3395586) /Source="Nicolas_upshifts" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3395611..3395617) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3395632..3395638 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3395653..3395672 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3395663 /Source="Nicolas_upshifts" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 3395708..3396223 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25733610; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling expressionof tyrZ" /protein_id="NP_391724.1" /db_xref="EnsemblGenomes-Gn:BSU38450" /db_xref="EnsemblGenomes-Tr:CAB15871" /db_xref="GOA:P25150" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10556" /db_xref="UniProtKB/Swiss-Prot:P25150" /translation="MERSHQHQQLRKEEHDTLSKLKQMPVESLNLEAISIATNLYRSA QRLRVKMETEVLSTYNLSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLE KKSFCRKSIDTRDRRLVFVSITDSGKQAIEELYPEFHKGETELIAGMTKDEQKILTGL LRKVADNLHTT*" /label="tyrZR CDS" gene 3395708..3396223 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /label="tyrZR gene" misc_RNA 3396224..3396430 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /product="T-box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboYB RNA" gene 3396224..3396430 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /label="tboYB gene" downshifts 3396390 /Source="Nicolas_upshifts" /id="D1993" /incds=0 /nref=15 /ntot=112 /MaxReadThrough="1.84575" /MaxDrop="4.56656" /score="23.8000948" /energy="-14.5" /TU="NA" /idTUdmin="U3028" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3396472..3397713 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /EC_number="6.1.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1735721, 1806041, 25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1735721, 1806041, 25733610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_391725.1" /db_xref="EnsemblGenomes-Gn:BSU38460" /db_xref="EnsemblGenomes-Tr:CAB15872" /db_xref="GOA:P25151" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024108" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10555" /db_xref="UniProtKB/Swiss-Prot:P25151" /translation="MMRTFEQLTASQQKEVERQLQLYMTGAHEVIPPEELKAKLVKSI STGTPLKIKLGLDPSAPDVHLGHTVVLNKLRQFQENGHIVQLLIGDFTGKIGDPTGKS AARKQLTDEEVQHNAKTYFEQFGKVLDPEKVELHYNSKWLKTLNLEDVIELAGKITVA RLMERDDFEERIAMQKPISLHEFFYPLMQGYDSVVLESDIELGGTDQHFNVLMGRHFQ ERYNKEKQVVILMPLLEGLDGVEKMSKSKHNYIGINEHPNDMYGKTMSLPDSLMKKYI HLATDLELEEKKQLVKDLETGAVHPRDAKMLLARTIVRMYHGEKAAEAAEHSFKTVFQ ENSLPEDIPAVNWKGEKTIAMIDLLVKLKLLSSKSEARRMIQNGGVRIDGEKVTDVHA KAEIRENMIIQVGKRKFLKLQ*" /label="tyrZ CDS" gene 3396472..3397713 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /label="tyrZ gene" promotor_-35 3397804..3397812 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3397823..3397841 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3397834 /Source="Nicolas_upshifts" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="upshifts" CDS 3397869..3399236 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15668014, 23426795, 26898926, 28257579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668014, 23426795, 26898926, 28257579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported double-zinc aminopeptidase" /protein_id="NP_391726.1" /db_xref="EnsemblGenomes-Gn:BSU38470" /db_xref="EnsemblGenomes-Tr:CAB15873" /db_xref="GOA:P25152" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR007484" /db_xref="SubtiList:BG10554" /db_xref="UniProtKB/Swiss-Prot:P25152" /translation="MKKLLTVMTMAVLTAGTLLLPAQSVTPAAHAVQISNSERELPFK AKHAYSTISQLSEAIGPRIAGTAAEKKSALLIASSMRKLKLDVKVQRFNIPDRLEGTL SSAGRDILLQAASGSAPTEEQGLTAPLYNAGLGYQKDFTADAKGKIALISRGDLTYYE KAKNAEAAGAKAVIIYNNKESLVPMTPNLSGNKVGIPVVGIKKEDGEALTQQKEATLK LKAFTNQTSQNIIGIKKPKNIKHPDIVYVTAHYDSVPFSPGANDNGSGTSVMLEMARV LKSVPSDKEIRFIAFGAEELGLLGSSHYVDHLSEKELKRSEVNFNLDMVGTSWEKASE LYVNTLDGQSNYVWESSRTAAEKIGFDSLSLTQGGSSDHVPFHEAGIDSANFIWGDPE TEEVEPWYHTPEDSIEHISKERLQQAGDLVTAAVYEAVKKEKKPKTIKKQMKAKASDI FEDIK*" /label="eapD CDS" gene 3397869..3399236 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /label="eapD gene" downshifts 3399213 /Source="Nicolas_upshifts" /id="D1994" /incds=0 /nref=3 /ntot=37 /MaxReadThrough="1.38814" /MaxDrop="6.05871" /score="27.7635079" /energy="-13.3" /TU="NA" /idTUdmin="U3029" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(3399266..3399898) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /EC_number="2.7.6.5" /function="16.7: Manage energy" /function="16.3: Control" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_391727.1" /db_xref="EnsemblGenomes-Gn:BSU38480" /db_xref="EnsemblGenomes-Tr:CAB15874" /db_xref="GOA:P39583" /db_xref="InterPro:IPR007685" /db_xref="SubtiList:BG10553" /db_xref="UniProtKB/Swiss-Prot:P39583" /translation="MDLSVTHMDDLKTVMEDWKNELLVYKFALDALDTKFSIISQEYN LIHGHNPIEHTKSRVKSFESIVNKLMRKGCEITTKEMKEHIHDIAGVRIICSFISDIY NVVNVLKQHEDLRIVKVKDYIQTPKPNGYRSLHLIIEMPVNLTNRVEYVKAEIQIRTI AMDFWASLEHKIYYKLNNDVPKQLTDELKEAAEIAHYLDEKMLGIKKEVD*" /label="relQ CDS" gene complement(3399266..3399898) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /label="relQ gene" downshifts complement(3399284) /Source="Nicolas_upshifts" /id="D1995" /incds=0 /nref=200 /ntot=257 /MaxReadThrough="2.49976" /MaxDrop="5.49802" /score="47.236042" /energy="-13.3" /TU="NA" /idTUdmin="U3030" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3399934..3399949) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3399942) /Source="Nicolas_upshifts" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3399962..3399970) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3400040..3400975) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /EC_number="2.5.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6780514, 9573170, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-dihydroxy-2-naphthoate octaprenyltransferase" /protein_id="NP_391728.1" /db_xref="EnsemblGenomes-Gn:BSU38490" /db_xref="EnsemblGenomes-Tr:CAB15875" /db_xref="GOA:P39582" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR004657" /db_xref="InterPro:IPR026046" /db_xref="SubtiList:BG10552" /db_xref="UniProtKB/Swiss-Prot:P39582" /translation="MNQTNKGEGQTAPQKESMGQILWQLTRPHTLTASFVPVLLGTVL AMFYVKVDLLLFLAMLFSCLWIQIATNLFNEYYDFKRGLDTAESVGIGGAIVRHGMKP KTILQLALASYGIAILLGVYICASSSWWLALIGLVGMAIGYLYTGGPLPIAYTPFGEL FSGICMGSVFVLISFFIQTDKINMQSILISIPIAILVGAINLSNNIRDIEEDKKGGRK TLAILMGHKGAVTLLAASFAVAYIWVVGLVITGAASPWLFVVFLSVPKPVQAVKGFVQ NEMPMNMIVAMKSTAQTNTFFGFLLSIGLLISYFR*" /label="menA CDS" gene complement(3400040..3400975) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /label="menA gene" downshifts complement(3400052) /Source="Nicolas_upshifts" /id="D1996" /incds=0 /nref=10 /ntot=113 /MaxReadThrough="3.08081" /MaxDrop="4.6874" /score="16.8971767" /energy="-8.5" /TU="NA" /idTUdmin="U3032" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3400719..3400728 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3400742..3400761 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3400746 /Source="Nicolas_upshifts" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3400976..3401063) /Source="Nicolas_S_feature" /locus_tag="new_3951662_3951749_c" /HighExp="LBGstat, Paraq, G180, LBGexp, G135, Oxctl, C30, Cold, Diami, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.81271400000000005" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.498" /TUlongSig="NA" /TUlongPSig="NA" /label="S1478" promotor_-10 complement(3401046..3401065) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3401063) /Source="Nicolas_upshifts" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3401081..3401085) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3401108..3401120) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3401108) /Source="Nicolas_upshifts" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3401135..3401141) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3401138..3401272) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514012.1" /translation="MECFELIHNKGKDTWSQKIFLTFKKCNVLKKIFLYLFVQVKAET *" /label="hypothetical protein CDS" gene complement(3401138..3401272) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /label="gene" promotor_-35 3401219..3401226 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-35" promotor_-10 3401240..3401259 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-10" upshifts 3401249 /Source="Nicolas_upshifts" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="upshifts" S_feature 3401252..3401356 /Source="Nicolas_S_feature" /locus_tag="new_3951938_3952042" /HighExp="H2O2, Paraq, Oxctl, G180, G150, C30, G135, LBGstat, dia15, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1479" promotor_-35 3401351..3401360 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3401358 /Source="Nicolas_upshifts" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3401372..3401387 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3401394) /Source="Nicolas_upshifts" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3401396..3401410) /Source="Nicolas_upshift_promotors" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3401422..3401571 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical membrane protein" /protein_id="YP_003097795.1" /db_xref="EnsemblGenomes-Gn:BSU38499" /db_xref="EnsemblGenomes-Tr:CAX52708" /db_xref="GOA:C0H3T3" /db_xref="InterPro:IPR021008" /db_xref="UniProtKB/Swiss-Prot:C0H3T3" /translation="MLQLMKQLYEKPAVKWTCHTGFYLMILLVLFFMYGFHTANTGSY IYNDF*" /label="ywzH CDS" gene 3401422..3401571 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /label="ywzH gene" CDS 3401589..3403100 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /EC_number="6.1.1.13" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine:D-alanyl-carrier protein ligase subunit" /protein_id="NP_391729.1" /db_xref="EnsemblGenomes-Gn:BSU38500" /db_xref="EnsemblGenomes-Tr:CAB15876" /db_xref="GOA:P39581" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR010072" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:3E7W" /db_xref="PDB:3E7X" /db_xref="SubtiList:BG10551" /db_xref="UniProtKB/Swiss-Prot:P39581" /translation="MKLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQ KRISGEKKSPILVYGHMEPHMIVSFLGSVKAGHPYIPVDLSIPSERIAKIIESSGAEL LIHAAGLSIDAVGQQIQTVSAEELLENEGGSVSQDQWVKEHETFYIIYTSGSTGNPKG VQISAANLQSFTDWICADFPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKD AVNKPKVLFEELKKSGLNVWTSTPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSV AKALLERFPKAKIFNTYGPTEATVAVTSVEITNDVISRSESLPVGFAKPDMNIFIMDE EGQPLPEGEKGEIVIAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFIQDGQIF CQGRLDFQIKLHGYRMELEEIEFHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHE FEKEFQLTSAIKKELAASLPAYMIPRKFIYQDHIQMTANGKIDRKRIGEEVLV*" /label="dltA CDS" gene 3401589..3403100 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /label="dltA gene" CDS 3403097..3404284 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 15849754, 16850406, 17263852; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine transferase from DCP to undecaprenylphosphate for lipoteichoic acid and wall teichoic acid" /protein_id="NP_391730.1" /db_xref="EnsemblGenomes-Gn:BSU38510" /db_xref="EnsemblGenomes-Tr:CAB15877" /db_xref="GOA:P39580" /db_xref="InterPro:IPR004299" /db_xref="InterPro:IPR024024" /db_xref="InterPro:IPR024194" /db_xref="SubtiList:BG10550" /db_xref="UniProtKB/Swiss-Prot:P39580" /translation="MTPYSSFLFFILLGILLLPTIILGLNGKRFQAYNMFISIIILAL IFSHDLHGVIALCLFTIWQVLLISGYLAYRQKANSGFVFCGAVIASILPLFLSKIWPF LSHPQPHHPPHNLISFLGISYLTFKGVQLIMEARDGLLKEQLPLHRLLYFILFFPTIS SGPIDRYRRFVKDEQKAWTKEEYADLLYTGIHKIFIGFLYKFIIGYAINTYFIMNLPA ITHNKILGNLLYMYGYSMYLFFDFAGYTMFAVGVSYIMGIKSPENFNKPFISKNIKDF WNRWHMSLSFWFRDYVFMRFVFWMTKKKWIKNRMAVSNIGYFLLFMLMGVWHGLAPQY IIYGLYHAVLMTCYNFFEKWNKKYKWLPSNRWTTILAIVITFHFVCFGFYIFSGKPFH HHH*" /label="dltB CDS" gene 3403097..3404284 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /label="dltB gene" CDS 3404301..3404537 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 26193422" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 26193422; Product type c: carrier" /codon_start=1 /transl_table=11 /product="D-alanyl carrier protein" /protein_id="NP_391731.1" /db_xref="EnsemblGenomes-Gn:BSU38520" /db_xref="EnsemblGenomes-Tr:CAB15878" /db_xref="GOA:P39579" /db_xref="InterPro:IPR003230" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:4BPF" /db_xref="PDB:4BPG" /db_xref="PDB:4BPH" /db_xref="SubtiList:BG10549" /db_xref="UniProtKB/Swiss-Prot:P39579" /translation="MDFKQEVLDVLAEVCQDDIVKENPDIEIFEEGLLDSFGTVELLL AIENRFDILVPITEFDRDVWNTPNNIVNQLSELK*" /label="dltC CDS" gene 3404301..3404537 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /label="dltC gene" CDS 3404537..3405715 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 17263852, 17600057, 23858088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine from undecaprenylphosphate tothe polyglycerolphosphate chain for lipoteichoic acid andwall teichoic acid synthesis" /protein_id="NP_391732.1" /db_xref="EnsemblGenomes-Gn:BSU38530" /db_xref="EnsemblGenomes-Tr:CAB15879" /db_xref="GOA:P39578" /db_xref="InterPro:IPR006998" /db_xref="InterPro:IPR023896" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG10548" /db_xref="UniProtKB/Swiss-Prot:P39578" /translation="MKKRFFGPIILAFILFAGAIAIPSSWLTGFITDKRVKESATALN PSMFQGLYLQDQMLKDPTYLPIYGSSELSRLDEFHPSNYFQVNNEGFTPYLVGKGGSQ SLIHSLNFAAHMDQLKGKKIVFIVSPQWFIKRGSDEQHFAPNYSALQGLDLAFNDQID PEIKKKMMKRMLRFKAVQNDAILSELYKAMVNGQTWKVNALKPAAKVYYSMLEKKDLY YSTTESSGPKRYISQSVKDKSWSELNKLADQSGKRHSGSNDFHIDNPVYKKLKPKVPK LKGKNKGRSYAVSPEYGDFEMMLDILKDAGAEPMFVTIPVNGKWYDYTGFPKKGRTDY YKKVNKQIRAKGFQVADFSGHEYDPYFMKDTIHIGWKGWVYVDKAIDEFYKTGKVTSS *" /label="dltD CDS" gene 3404537..3405715 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /label="dltD gene" S_feature 3405716..3405805 /Source="Nicolas_S_feature" /locus_tag="new_3956402_3956491" /HighExp="Paraq, H2O2, Oxctl, LBGexp, Lbexp, dia0, C30, Cold, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1480" CDS 3405806..3406564 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7797557, 14665680; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391733.2" /db_xref="EnsemblGenomes-Gn:BSU38540" /db_xref="EnsemblGenomes-Tr:CAB15880" /db_xref="GOA:P39577" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10547" /db_xref="UniProtKB/Swiss-Prot:P39577" /translation="MKMTNNTVLITGGSAGIGLELAKRLLELGNEVIICGRSEARLAE AKQQLPNIHTKQCDVADRSQREALYEWALKEYPNLNVLVNNAGIQKEIDFKKGTEELF VDGDEIELNFQAPVHLSALFTPHLMKQPEAAIVQVTSGLAFNPLAVYPVYCATKAALH SFSLTLRHQLRDTSVEVIEMAPPMVDTGLNQKSRDKQGLTYRGISSEEYVQYFLDGLK EGKQEITNERVEGLRDATRADYDRLFEQMNTQEN*" /label="dltE CDS" gene 3405806..3406564 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /label="dltE gene" downshifts 3406532 /Source="Nicolas_upshifts" /id="D1997" /incds=0 /nref=48 /ntot=172 /MaxReadThrough="5.94016" /MaxDrop="4.72547" /score="22.6844301" /energy="-13.7" /TU="U3035" /idTUdmin="U3035" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature complement(3406566..3407793) /Source="Nicolas_S_feature" /locus_tag="new_3957252_3958479_c" /HighExp="T0.30H, T1.0H, T1.30H, C30, B60, T2.0H, C90, Gly, T2.30H, S8" /AntisenseName="ilvK" /AntisenseCor="-0.12928749136401099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1481" promotor_-35 3406612..3406619 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3406633..3406652 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3406646 /Source="Nicolas_upshifts" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="upshifts" CDS 3406705..3407796 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 17611193, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 17611193, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid aminotransferase" /protein_id="NP_391734.2" /db_xref="EnsemblGenomes-Gn:BSU38550" /db_xref="EnsemblGenomes-Tr:CAB15881" /db_xref="GOA:P39576" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10546" /db_xref="UniProtKB/Swiss-Prot:P39576" /translation="MTKQTIRVELTSTKKPKPDPNQLSFGRVFTDHMFVMDYAADKGW YDPRIIPYQPLSMDPAAMVYHYGQTVFEGLKAYVSEDDHVLLFRPEKNMERLNQSNDR LCIPQIDEEQVLEGLKQLVAIDKDWIPNAEGTSLYIRPFIIATEPFLGVAASHTYKLL IILSPVGSYYKEGIKPVKIAVESEFVRAVKGGTGNAKTAGNYASSLKAQQVAEEKGFS QVLWLDGIEKKYIEEVGSMNIFFKINGEIVTPMLNGSILEGITRNSVIALLKHWGLQV SERKIAIDEVIQAHKDGILEEAFGTGTAAVISPVGELIWQDETLSINNGETGEIAKKL YDTITGIQKGAVADEFGWTTEVAALTESK*" /label="ilvK CDS" gene 3406705..3407796 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /label="ilvK gene" downshifts 3407698 /Source="Nicolas_upshifts" /id="D1998" /incds=1 /nref=10 /ntot=90 /MaxReadThrough="6.0829" /MaxDrop="3.1965" /score="32.8755878" /energy="-13.6" /TU="U3035,U3037" /idTUdmin="U3035" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 3407786 /Source="Nicolas_upshifts" /id="D1999" /incds=0 /nref=157 /ntot=264 /MaxReadThrough="2.21106" /MaxDrop="6.83094" /score="32.8755878" /energy="-13.6" /TU="NA" /idTUdmin="U3035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3407830..3409158) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8990303, 10438772, 22720735, 23874669, 24673833; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-beta-glucosidase" /protein_id="NP_391735.1" /db_xref="EnsemblGenomes-Gn:BSU38560" /db_xref="EnsemblGenomes-Tr:CAB15882" /db_xref="GOA:P46320" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11350" /db_xref="UniProtKB/Swiss-Prot:P46320" /translation="MTKGLKIVTIGGGSSYTPELVEGFIKRYDELPVRELWLVDIPEG EEKLNIVGTLAKRMVEKAGVPIDIHLTLDRRKALKDADFVTTQFRVGLLQARAKDERI PLKYGVIGQETNGPGGLFKGLRTIPVILEIAKDIEELCPNAWLVNFTNPAGMVTEALL RYSNLKKVVGLCNVPIGIKMGVAKALDVDVDRVEVQFAGLNHMVFGLDVFLDGVSVKE QVIEAMGDPKNAMTMKNISGAEWEPDFLKALNVIPCGYHRYYFKTKEMLEHELEASQT EGTRAEVVQKVEKELFELYKDPNLAIKPPQLEKRGGAYYSDAACNLISSIYNDKHDIQ PVNTINNGAIASIPDDSAVEVNCVMTKTGPKPIAVGDLPVSVRGLVQQIKSFERVAAE AAVTGDYQTALLAMTINPLVPSDTVAKQILDEMLEAHKAYLPQFFNKIEA*" /label="licH CDS" gene complement(3407830..3409158) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /label="licH gene" downshifts complement(3407838) /Source="Nicolas_upshifts" /id="D2000" /incds=0 /nref=12 /ntot=98 /MaxReadThrough="4.92442" /MaxDrop="6.75565" /score="45.1562234" /energy="-15.7" /TU="U3038" /idTUdmin="U3038" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" CDS complement(3409155..3409487) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIA component" /protein_id="NP_391736.1" /db_xref="EnsemblGenomes-Gn:BSU38570" /db_xref="EnsemblGenomes-Tr:CAB15883" /db_xref="GOA:P46319" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG11349" /db_xref="UniProtKB/Swiss-Prot:P46319" /translation="MNEEMEQIIFQIILHGGNGRSSAMEAIAAAKSGDAEEARKKLQD AAEELSKAHHYQTELIQNEAGGEKTEMTLLMVHAQDHLMNAMTVKDMAAEIIELYEKI TEQRGASI*" /label="licA CDS" gene complement(3409155..3409487) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /label="licA gene" CDS complement(3409506..3410864) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIC component" /protein_id="NP_391737.1" /db_xref="EnsemblGenomes-Gn:BSU38580" /db_xref="EnsemblGenomes-Tr:CAB15884" /db_xref="GOA:P46317" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG11348" /db_xref="UniProtKB/Swiss-Prot:P46317" /translation="MNKVNQILEEKVMPIAGRIAGQRHLQALRDGIILTMPLIIIGSF FLIIGNLPIPGYAEFMAKTFGSSWSEKLAYPVDATFEIMGLVAAFGIAYRLAEKYGVD ALSAGAISLAAFLLATPYQVPFMPDGATKEIMVGGGIPLSLMGSKGLFVAMIIAMVST EIYRLIIQRNLVFKMPDGVPPAVSKSFVALIPGFAVIFLIWAARLIVEATPFESLHNI VSVLLGTPLSILGGSLGGSLVAEAVKMLLWACGLHGANIVGGVMAPIWYGAMDANRIA FQAGEELPKIFTQQFFDIWVNIGGSGATLALVVTMFLRARSKQMKQLGKLAVGPAIFN INEPIIFGMPIVMNPMLLLPFIITPLVTVTLTYIGMSTGLVAKPAGIAVPWTMPPIFS GYLATGGKVSGAVMQAINIAVSFVVYYPFFRMWDKQKLKEENDLELVQTPAATDDKEA AL*" /label="licC CDS" gene complement(3409506..3410864) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /label="licC gene" CDS complement(3410880..3411188) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 23874669; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIB component" /protein_id="NP_391738.1" /db_xref="EnsemblGenomes-Gn:BSU38590" /db_xref="EnsemblGenomes-Tr:CAB15885" /db_xref="GOA:P46318" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11347" /db_xref="UniProtKB/Swiss-Prot:P46318" /translation="MNILLVCAAGMSTSLLVSKMEKSAQEQGKDYTIWAVSGDSVQNH IDKADVLLLGPQVRYMLPQLKKLGESKGVPVDVINTVHYGTCNGAEVLKSAEQLGHVS *" /label="licB CDS" gene complement(3410880..3411188) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /label="licB gene" promotor_-10 complement(3411233..3411252) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3411249) /Source="Nicolas_upshifts" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3411266..3411272) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3411317) /Source="Nicolas_upshifts" /id="D2001" /incds=0 /nref=3 /ntot=74 /MaxReadThrough="3.19679" /MaxDrop="2.70222" /score="27.6067633" /energy="-11.1" /TU="U3040" /idTUdmin="U3040" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3411317..3413242) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 9353933, 10438772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 9353933, 10438772; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the lichenan operon" /protein_id="NP_391739.1" /db_xref="EnsemblGenomes-Gn:BSU38600" /db_xref="EnsemblGenomes-Tr:CAB15886" /db_xref="GOA:P46321" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG11346" /db_xref="UniProtKB/Swiss-Prot:P46321" /translation="MLHGRLRDILRLLMAAEAPVTSSFFAAQLNVTTRTVRNDIKELQ GVLSGHGAFVQSVRGSGYKLRIDDEQVFRTLLQDEFQQKKGLPVLPEERMAYLMKRLL LADHYLKLDELAEELFISKSTLQTDLKEVKKRLLPYRIVMETRPNYGFKLRGDEVQMR YCMAEYIVDERETEIDVLNEKADILPKEEIEIIRSAILKKMKNDRIPLSNMGLNNLII HIAIACKRIRTENYVSLFPKDMDHILHQKEYQAAEAIVKELESKLSVTFPKDETAYIT MHLLGTKRMTQSQCGEDTFSIEEETDQLTLAMIKAVDRELKLGILHDKELKIGLALHM KPAISRNRYGMNLRNPMLAAIKEHYPLAFEAGIIAGIVIKEQTGIEIHENEIGYLALH FGAAIERKKTESPPKRCIIVCASGAGSAQLLREKLRSHFGKRLDILGTAEYYSLDQMS YESIDFVISTIPIKKELPVPVLKVNTILGGTDFTKIESILSDEKEKANRYLKKELVFF QEDLRSKEEVIQFLGQKVVECGFADEEIIDSIFEREDMSPTCFGNLVAIPHPLVPQTK TTFWAVCTLKKPIDWESQRVQFVCLLCVEKENKADLQSMYKLLGSILDDPAAMNQLIK CRSYQELSDVFDQKMLS*" /label="licR CDS" gene complement(3411317..3413242) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /label="licR gene" promotor_-35 3411980..3411989 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3412003..3412022 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3412011 /Source="Nicolas_upshifts" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3413315..3413332) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-10" upshifts complement(3413339) /Source="Nicolas_upshifts" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="upshifts" promotor_-35 complement(3413347..3413354) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-35" CDS complement(3413405..3413563) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391740.1" /db_xref="EnsemblGenomes-Gn:BSU38610" /db_xref="EnsemblGenomes-Tr:CAB15887" /db_xref="SubtiList:BG14169" /db_xref="UniProtKB/Swiss-Prot:O32283" /translation="MVEKKEGRIGALKKMIKTVIKWAPVIYPIVRKIMKDRKASKQKN MSASRTAG*" /label="yxzF CDS" gene complement(3413405..3413563) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /label="yxzF gene" downshifts complement(3413432) /Source="Nicolas_upshifts" /id="D2002" /incds=0 /nref=75 /ntot=208 /MaxReadThrough="0.739420000000001" /MaxDrop="6.4099" /score="27.6067633" /energy="-11.1" /TU="NA" /idTUdmin="U3041" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3413592..3414182) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /EC_number="3.2.2.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14729667, 27698084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14729667, 27698084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-alkylated purines and hypoxanthine DNA glycosidase" /protein_id="NP_391741.1" /db_xref="EnsemblGenomes-Gn:BSU38620" /db_xref="EnsemblGenomes-Tr:CAB15888" /db_xref="GOA:P94378" /db_xref="InterPro:IPR003180" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036995" /db_xref="SubtiList:BG12555" /db_xref="UniProtKB/Swiss-Prot:P94378" /translation="MTREKNPLPITFYQKTALELAPSLLGCLLVKETDEGTASGYIVE TEAYMGAGDRAAHSFNNRRTKRTEIMFAEAGRVYTYVMHTHTLLNVVAAEEDVPQAVL IRAIEPHEGQLLMEERRPGRSPREWTNGPGKLTKALGVTMNDYGRWITEQPLYIESGY TPEAISTGPRIGIDNSGEARDYPWRFWVTGNRYVSR*" /label="aag CDS" gene complement(3413592..3414182) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /label="aag gene" promotor_-10 complement(3414210..3414228) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3414221) /Source="Nicolas_upshifts" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3414242..3414248) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3414251..3414257 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3414273..3414291 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3414276 /Source="Nicolas_upshifts" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="upshifts" CDS 3414311..3415954 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9393707, 9555886, 10503549, 24123749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9555886, 10503549, 24123749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="major catalase in spores" /protein_id="NP_391742.1" /db_xref="EnsemblGenomes-Gn:BSU38630" /db_xref="EnsemblGenomes-Tr:CAB15889" /db_xref="GOA:P94377" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11945" /db_xref="UniProtKB/Swiss-Prot:P94377" /translation="MKDDHQNKQHQSNAQGSEEAFSHKTSGKNESEDTLTNRQGHPVT DNQNVRTVGNRGPTTLENYDFLEKISHFDRERIPERVVHARGAGAHGYFEAYGSFGDE PISTYTRAKLFQEKGKKTPAFVRFSTVNHGKHSPETLRDPRGFAVKLYTEDGNWDLVG NNLKIFFIRDPLKFPDLVHAFQPDPVTNIQDGERIFDFISQSPEATHMITFLFSPWGI PANYRQMQGSGVHAYKWVNEEGKAVLVKYHFEPKQGIRNLTQKEAEEIQGKNFNHATQ DLYDAIENGDYPEWEVYAQIMSDDEHPELDFDPLDPTKLWYKDDFPWKPIGKLVLNKN PENYHAEVEQASFGTGVLVDGLDFSDDKLLQGRTFAYSDTQRYRVGANYLQLPINSPK KHVATNQEGGQMQYRVDRAEGQNPHVNYEPSIMGGLKEAKQDGKDHTPHVEGDVKREA IDRTNNFGQAGETYRRFTEFERNELITNLVNTLSTCRKEIQDQMIENFTKADPDYGKR VAEGLKKVSENNSNGPIGTTETEQAAKQAEQESHPSDPY*" /label="katX CDS" gene 3414311..3415954 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /label="katX gene" S_feature complement(3414448..3415997) /Source="Nicolas_S_feature" /locus_tag="new_3965134_3966683_c" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T3.0H, S8, T3.30H, S6, T0.0H" /AntisenseName="katX" /AntisenseCor="0.28909015498211399" /AntisenseRegPval="-5.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1482" downshifts 3415949 /Source="Nicolas_upshifts" /id="D2003" /incds=0 /nref=28 /ntot=49 /MaxReadThrough="0.942820000000001" /MaxDrop="5.69337" /score="45.0252072" /energy="-12.7" /TU="NA" /idTUdmin="U3042" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3415999..3416090) /Source="Nicolas_S_feature" /locus_tag="new_3966685_3966776_c" /HighExp="T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, T3.30H, T4.0H, T3.0H, T0.0H, T5.0H" /AntisenseName="yxlH" /AntisenseCor="-4.8005444617814199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1483" promotor_-35 3416001..3416007 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3416015 /Source="Nicolas_upshifts" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3416022..3416041 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3416042) /Source="Nicolas_upshifts" /id="D2004" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="3.81662" /MaxDrop="3.1285" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1557" /isTUend="FALSE" /label="downshifts" CDS 3416059..3417261 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391743.1" /db_xref="EnsemblGenomes-Gn:BSU38640" /db_xref="EnsemblGenomes-Tr:CAB15890" /db_xref="GOA:P94376" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12554" /db_xref="UniProtKB/Swiss-Prot:P94376" /translation="MELQQDLIPQKKTIGALDHAVFLCMVFCFWFSGYIYVPVFSLYL EDLHFSYGAIGIILGSYGVTQILLRFPLGLLSDILFSLRKQLLIAGFGFSVLSSLLFL MFDSFFFVLAARLFAGITASTWVMATILYAHYFNNGNASKAMGIMQFFTVMPQFASIV FCGLAAAHLGRQVPFWMALAASAAGLVICCFIQDPSAPPANRGTIRVNQYIKDTLRLP KLKLFTILSMTAHAVLFITVFGFTPLYMNQLGMGDAELLWVMSAFFLPHAAATLSFVF LRFTSRIAYSVMLISFAVTGVCLLYVPFLAALFTVCITHACIGLALGFVFPLLLSHVV EISSARLKMSVMGFYQSFYALGIFLGPLLAGKIAQLIGLAGVFYGAGSLAFAAFFVML AQKRNMIN*" /label="yxlH CDS" gene 3416059..3417261 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /label="yxlH gene" S_feature complement(3416092..3417257) /Source="Nicolas_S_feature" /locus_tag="new_3966778_3967943_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T0.0H, T3.0H, T3.30H, T-0.40H, T4.0H" /AntisenseName="yxlH" /AntisenseCor="-4.5703316381945601E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1484" downshifts complement(3416135) /Source="Nicolas_upshifts" /id="D2005" /incds=1 /nref=3 /ntot=61 /MaxReadThrough="6.44992" /MaxDrop="2.92619" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS complement(3417258..3418034) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC-transporter (permease)" /protein_id="NP_391744.2" /db_xref="EnsemblGenomes-Gn:BSU38650" /db_xref="EnsemblGenomes-Tr:CAB15891" /db_xref="GOA:P94375" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12553" /db_xref="UniProtKB/Swiss-Prot:P94375" /translation="MKVMMALLQKEWLEGWKSGKLIWLPIAMMIVGLTQPLTIYYMPE IIAHGGNLPDGMKISFTMPSGSEVMVSTLSQFNTLGMALVIFSVMGSVANERNQGVTA LIMSRPVTAAHYIVSKWLIQSVIGIMSFAAGYGLAYYYVRLLFEDASFSRFAASLGLY ALWVIFIVTAGLAGSTIFRSVGAAAACGIGLTAAVSFAVSLFPDGAKWLPAEICKQAE HILLHGERADFFGWSLTFSILCIMLLAVFSVWRFRRYESY*" /label="yxlG CDS" gene complement(3417258..3418034) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /label="yxlG gene" CDS complement(3418031..3418918) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter component (ATP-binding protein)" /protein_id="NP_391745.1" /db_xref="EnsemblGenomes-Gn:BSU38660" /db_xref="EnsemblGenomes-Tr:CAB15892" /db_xref="GOA:P94374" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12552" /db_xref="UniProtKB/Swiss-Prot:P94374" /translation="MLSIESLCKSYRHHEAVKNVSFHVNENECVALLGPNGAGKTTTL QMLAGLLSPTSGTIKLLGEKKLDRRLIGYLPQYPAFYSWMTANEFLTFAGRLSGLSKR KCQEKIGEMLEFVGLHEAAHKRIGGYSGGMKQRLGLAQALLHKPKFLILDEPVSALDP TGRFEVLDMMRELKKHMAVLFSTHVLHDAEQVCDQVVIMKNGEISWKGELQELKQQQQ TNVFTLSVKEKLEGWLEEKPYVSAIVYKNPSQAVFELPDIHAGRSLLSDCIRKGLTVT RFEQKTESLEDVYLKVVHA*" /label="yxlF CDS" gene complement(3418031..3418918) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /label="yxlF gene" CDS complement(3418925..3419113) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma-Y activity" /protein_id="NP_391746.1" /db_xref="EnsemblGenomes-Gn:BSU38670" /db_xref="EnsemblGenomes-Tr:CAB15893" /db_xref="GOA:P94373" /db_xref="InterPro:IPR027379" /db_xref="SubtiList:BG12551" /db_xref="UniProtKB/Swiss-Prot:P94373" /translation="MNISWEMILPLIVLQLALAVFALISCIKEERTNGPKWMWAAIIV CINIIGPILFFTVGRKQR*" /label="yxlE CDS" gene complement(3418925..3419113) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /label="yxlE gene" CDS complement(3419110..3419316) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative sigma-Y antisigma factor component" /protein_id="NP_391747.1" /db_xref="EnsemblGenomes-Gn:BSU38680" /db_xref="EnsemblGenomes-Tr:CAB15894" /db_xref="GOA:P94372" /db_xref="SubtiList:BG12550" /db_xref="UniProtKB/Swiss-Prot:P94372" /translation="MTQTEIIITVAACLIVLAQGIFLFIDAKKRNHMAWVWGIVGLIQ APMPLICYYFFVIRPDRKKRGIKQ*" /label="yxlD CDS" gene complement(3419110..3419316) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /label="yxlD gene" CDS complement(3419313..3419633) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sigma-Y antisigma factor" /protein_id="NP_391748.1" /db_xref="EnsemblGenomes-Gn:BSU38690" /db_xref="EnsemblGenomes-Tr:CAB15895" /db_xref="GOA:P94371" /db_xref="InterPro:IPR035238" /db_xref="SubtiList:BG12549" /db_xref="UniProtKB/Swiss-Prot:P94371" /translation="MNKEKLSDHLKSEWKKIDQTANPSIPNQKELLHQLSQMKAEYRK KLLQEIILFVFCALMVVSAAILAFTQAPAVFIVLQVCVLAVLPILIAAEKKRHLGECE VKRG*" /label="yxlC CDS" gene complement(3419313..3419633) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /label="yxlC gene" promotor_-35 3419446..3419455 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3419468..3419487 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3419470 /Source="Nicolas_upshifts" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3419626..3420162) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma-Y)" /protein_id="NP_391749.1" /db_xref="EnsemblGenomes-Gn:BSU38700" /db_xref="EnsemblGenomes-Tr:CAB15896" /db_xref="GOA:P94370" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11975" /db_xref="UniProtKB/Swiss-Prot:P94370" /translation="MDTQEEQRLIQQAKEGNDEAFTALFHYHYSFLYKYLLKLSLHPD LSEELVQETFLKGYIHLRSFQGRSKFSTWLISIASRLYLDHQKKRKREWKRNQTVTEE TIRKIKWDVSAKGAEWSETLDLFSKLDPKLRTPVLLRHYYGYTYAEIGVMLQIKEGTV KSRVHKGLQQIRKEWDDE*" /label="sigY CDS" gene complement(3419626..3420162) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /label="sigY gene" upshifts complement(3420190) /Source="Nicolas_upshifts" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3420191..3420206) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3420218..3420227) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3420293..3420300 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3420314..3420333 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3420323 /Source="Nicolas_upshifts" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="upshifts" CDS 3420374..3421747 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2191181, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine-cytosine (pyridoxine) permease" /protein_id="NP_391750.1" /db_xref="EnsemblGenomes-Gn:BSU38710" /db_xref="EnsemblGenomes-Tr:CAB15897" /db_xref="GOA:P94369" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR026030" /db_xref="SubtiList:BG12548" /db_xref="UniProtKB/Swiss-Prot:P94369" /translation="MKVERRTIEYIPNEERHGKAKDLFPVWFGANMHITTLVTGTIPV AMGLNLFWSVAAIICGTLIGAIFMASHSAQGPQLGIPQMIQSRAQFGVIGAILPLFLV MFIYLGFFASSTILAAGTLSSFVPIPGSWSIIGLSAVCFLLTIFGHDLIHKMQKILSW TSFAVFFAATILIFQLPIPAGSWIPGAIDLPIFLVAVSAVATWQLAYAPYVADYSRYL PVKTPASKTFWYSYAGTSVSSIWMMLLGALLTTSLPDFTANSGSQIVQLFGPFSFIML IIVLFGQMAINVFNLYGAFMSTTTTLEPFLKLKVTPKVRIIMILGVTLVGTVLSLLGQ SNFMELFLNFIFFISYFLIPWTAINLVDYYFVRHGKYQVKAMFDVNGPYGKVNWITTI AFVLSILLEIPFINTSFYIGPLAKMFGGGDIAWIIGLAVPSVLYYVLMKPRLKKRAGY QEKLSSL*" /label="yxlA CDS" gene 3420374..3421747 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /label="yxlA gene" S_feature complement(3420654..3421196) /Source="Nicolas_S_feature" /locus_tag="new_3971340_3971882_c" /HighExp="Etha, LBGstat, T1.0H, T0.30H, Diami, T1.30H, dia15, G150, G135, G180" /AntisenseName="yxlA" /AntisenseCor="-8.6586358833710395E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1485" promotor_-10 complement(3421184..3421203) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3421196) /Source="Nicolas_upshifts" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3421218..3421225) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3421582 /Source="Nicolas_upshifts" /id="D2006" /incds=1 /nref=30 /ntot=136 /MaxReadThrough="1.87017" /MaxDrop="3.59478" /score="22.3054019" /energy="-12.9" /TU="NA" /idTUdmin="U3046" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3421762..3422592) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12457846, 21994945, 22940582, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12457846, 21994945, 22940582, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H dehydratase" /protein_id="NP_391751.1" /db_xref="EnsemblGenomes-Gn:BSU38720" /db_xref="EnsemblGenomes-Tr:CAB15898" /db_xref="GOA:P94368" /db_xref="InterPro:IPR000631" /db_xref="InterPro:IPR017953" /db_xref="InterPro:IPR029056" /db_xref="PDB:1KYH" /db_xref="PDB:3RPH" /db_xref="PDB:3RPZ" /db_xref="PDB:3RQ2" /db_xref="PDB:3RQ5" /db_xref="PDB:3RQ6" /db_xref="PDB:3RQ8" /db_xref="PDB:3RQH" /db_xref="PDB:3RQQ" /db_xref="PDB:3RQX" /db_xref="SubtiList:BG12547" /db_xref="UniProtKB/Swiss-Prot:P94368" /translation="MNVPFWTEEHVRATLPERDAESHKGTYGTALLLAGSDDMPGAAL LAGLGAMRSGLGKLVIGTSENVIPLIVPVLPEATYWRDGWKKAADAQLEETYRAIAIG PGLPQTESVQQAVDHVLTADCPVILDAGALAKRTYPKREGPVILTPHPGEFFRMTGVP VNELQKKRAEYAKEWAAQLQTVIVLKGNQTVIAFPDGDCWLNPTGNGALAKGGTGDTL TGMILGMLCCHEDPKHAVLNAVYLHGACAELWTDEHSAHTLLAHELSDILPRVWKRFE *" /label="nnrA CDS" gene complement(3421762..3422592) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /label="nnrA gene" downshifts complement(3421768) /Source="Nicolas_upshifts" /id="D2007" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="3.50755" /MaxDrop="3.84264" /score="7.61210868" /energy="-12.9" /TU="U3048" /idTUdmin="U3051" /TUdmin=792 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3422611..3422629) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3422626) /Source="Nicolas_upshifts" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3422644..3422650) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3422670) /Source="Nicolas_upshifts" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3422672..3422691) /Source="Nicolas_upshift_promotors" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3422678..3424405) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391752.1" /db_xref="EnsemblGenomes-Gn:BSU38730" /db_xref="EnsemblGenomes-Tr:CAB15899" /db_xref="GOA:P94367" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014223" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11928" /db_xref="UniProtKB/Swiss-Prot:P94367" /translation="MKKEEWILPYIKQNARLFVLVIFLGAVTIFSAAFLMFTSGFLIS KAATRPENILLIYVPIVAVRTFGIARSVSRYVERLVGHHIILKIVSDMRVRLYNMLEP GALMLRSRFRTGDMLGILSEDIEHLQDAFLKTIFPAISALLLYAVSVIALGFFSWPFA ILLALYLFVLVVLFPVVSLLVTRAKNAKLKSGRNVLYSRLTDAVMGVSDWMFSGRRHA FIDAYEKEERDWFELERKKQRFTRWRDFAAQCLVAGLILLMLFWTAGQQADGELAKTM IAAFVLVVFPLTEAFLPLSDALGEVPGYQDSIRRMNNVAPQPEASQTESGDQILDLQD VTLAFRDVTFSYDNSSQVLHNFSFTLRQGEKMALLGRSGSGKSTSLALIEGALKPDSG SVTLNGVETALLKDQIADAVAVLNQKPHLFDTSILNNIRLGNGEASDEDVRRAAKQVK LHDYIESLPDGYHTSVQETGIRFSGGERQRIALARILLQDTPIIILDEPTVGLDPITE RELMETVFEVLKGKTILWITHHLAGVEAADKIVFLENGKTEMEGTHEELLAANERYRR LYHLDVPVK*" /label="cydD CDS" gene complement(3422678..3424405) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /label="cydD gene" downshifts complement(3422777) /Source="Nicolas_upshifts" /id="D2008" /incds=1 /nref=7 /ntot=46 /MaxReadThrough="5.39758" /MaxDrop="3.66431" /score="25.0271963" /energy="-10.6" /TU="U3051" /idTUdmin="U3051" /TUdmin="-217" /isTUend="FALSE" /label="downshifts" CDS complement(3424402..3426105) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391753.1" /db_xref="EnsemblGenomes-Gn:BSU38740" /db_xref="EnsemblGenomes-Tr:CAB15900" /db_xref="GOA:P94366" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014216" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11927" /db_xref="UniProtKB/Swiss-Prot:P94366" /translation="MGKDLFRYKGMKRILTLITCLTLIQTAAIIMQAEWLSEAVTGLF NGKGITSLLPVIGFFLIAFIARHGMTVARQKIVYQYAARTGADLRKSFLDQLFRLGPR FAKKEGTGQMVTLAMEGISQFRRYLELFLPKMVSMAIVPAAVVIYVFFQDRTSAIILV AAMPILIIFMILLGLVAQRKADRQWKSYQRLSNHFVDSLRGLETLRFLGLSKSHSKNI FYVSERYRKATMSTLRVAFLSSFALDFFTMLSVATVAVFLGLRLIDGDILLGPALTAL ILAPEYFLPVREVGNDYHATLNGQEAGKTIQEILSQPGFKEETPLQLEAWSDQDELKL SGVSVGRSVSDIHLSFKGKKKIGIIGASGAGKSTLIDILGGFLEPDGGMIEVNGTSRS HLQDGSWQKNLLYIPQHPYIFDDTLGNNIRFYHPSASAEDTTRAAASAGLTELVNNLP DGLEGRIGEGGRALSGGQAQRVALARAFLGNRPILLLDEPTAHLDIETEYEIKETMLD LFEDKLVFLATHRLHWMLDMDEIIVLDGGRVAEIGTHNELLEKNGVYTKLVKAQLGER A*" /label="cydC CDS" gene complement(3424402..3426105) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /label="cydC gene" CDS complement(3426105..3427121) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit II)" /protein_id="NP_391754.1" /db_xref="EnsemblGenomes-Gn:BSU38750" /db_xref="EnsemblGenomes-Tr:CAB15901" /db_xref="GOA:P94365" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG11926" /db_xref="UniProtKB/Swiss-Prot:P94365" /translation="MASLHDLWFILVAVLFVGFFFLEGFDFGVGMATRFLGHNELERR VLINTIGPFWDANEVWLLTGAGAIFAAFPNWYATMLSGYYIPFVIVLLALMGRGVAFE FRGKVDHLKWVKVWDWVVFFGSLIPPFVLGVLFTTLFRGMPIDADMNIHAHVSDYINV YSILGGVTVTLLCFQHGLMFITLRTIGDLQNRARKMAQKIMGVVFVAVLAFAALSAYQ TDMFTRRGEITIPLAVLIVICFMLAAVFIRKKKDGWTFGMTGAGLALTVGMIFISLFP RVMVSSLHSAYDLTVANASSGDYSLKVMSIAALTLLPFVIGSQIWSYYVFRKRVSHKE PMTY*" /label="cydB CDS" gene complement(3426105..3427121) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /label="cydB gene" promotor_-10 complement(3426995..3427013) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3427004) /Source="Nicolas_upshifts" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3427029..3427034) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3427105..3428511) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit I)" /protein_id="NP_391755.1" /db_xref="EnsemblGenomes-Gn:BSU38760" /db_xref="EnsemblGenomes-Tr:CAB15902" /db_xref="GOA:P94364" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG11925" /db_xref="UniProtKB/Swiss-Prot:P94364" /translation="MSELVLARIQFASTTLFHFLFVPMSIGLVFMVALMETLYLVKKN ELYLKMAKFWGHLFLINFAVGVVTGILQEFQFGLNWSDYSRFVGDVFGAPLAIEALLA FFMESIFIGLWIFGWDRLPKKIHALCIWLVSFGTIMSSFWILTANSFMQEPVGFTIKN GRAEMNDFGALITNPQLWVEFPHVIFGALATGAFFIAGVSAFKLLKKKEVPFFKQSFK LAMIVGLCAGLGVGLSGHMQAEHLMESQPMKMAASEGLWEDSGDPAAWTAFATIDTKN EKSSNEIKVPYALSYLAYQKFSGSVKGMKTLQAEYEKIYGKGDYIPPVKTTFWSFRIM VGAGVVMILAALGGLWLNRRKKLENSKWYLRIMIALISFPFLANSAGWIMTEIGRQPW TVMGLMTTAQSVSPNVTAGSLLFSIIAFGVMYMILGALLVFLFIREIKKGAEHDNHHD VPVSTDPFSQEVYHGISS*" /label="cydA CDS" gene complement(3427105..3428511) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /label="cydA gene" S_feature complement(3428512..3428720) /Source="Nicolas_S_feature" /locus_tag="new_3979198_3979406_c" /HighExp="M0t45, ferm, UNK1, Gly, Lbexp, Lbstat, dia0, nit, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1486" promotor_-10 complement(3428703..3428722) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3428720) /Source="Nicolas_upshifts" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3428722..3428830) /Source="Nicolas_S_feature" /locus_tag="new_3979408_3979516_c" /HighExp="LPhT, LBGtran, ferm, LBGstat, M0t45, dia0, Etha, dia5, Lbexp, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1487" promotor_-35 complement(3428736..3428741) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3428827..3428846) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-10" upshifts complement(3428842) /Source="Nicolas_upshifts" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="upshifts" promotor_-35 complement(3428860..3428867) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-35" promotor_-35 3428988..3428995 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3429005 /Source="Nicolas_upshifts" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3429010..3429028 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3429067..3430419 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11566984, 12525174, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11566984, 12525174, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="citrate/malate/H+ symporter" /protein_id="NP_391756.1" /db_xref="EnsemblGenomes-Gn:BSU38770" /db_xref="EnsemblGenomes-Tr:CAB15903" /db_xref="GOA:P94363" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12546" /db_xref="UniProtKB/Swiss-Prot:P94363" /translation="MGELQTHMQLQTDTIHEGVRKENWFAKAMNIKVGIIPLPVYALL FILITVFVMHHDVKSDILTSIAVMAFFGFTFAQIGKSIPIVRSIGGPAILATFIPSAV VYYHLLPNDIVKSTTEFTENSNFLYLFIAGIVVGSILGMKRETLVKAFMKIFIPLIVG SVTAAIVGLAVGTLLGLGFQHTLLYIVIPIMAGGVGEGAIPLSIGYSDIMPISQGEAF ALVLPSIMLGSLCAIILAGLLNRIGKKKPEWTGNGKVDRSEEESPALEESQSGQQMFN LSLFASGGILAVSLYLVGMLAHDFFGFPAPVAMLLLAVLIKLFRLVPASIENGAFGVS RFFSTAVTYPLLFAIGVSMTPWDKLVAAFNLSNIITILSVVVTMMAVGFFTGKWLNMY PIETAIINACHSGQGGTGDVAILSAAERLELMPFAQVSTRIGGAITVSLTLLLLHQFY *" /label="cimH CDS" gene 3429067..3430419 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /label="cimH gene" S_feature complement(3430018..3432500) /Source="Nicolas_S_feature" /locus_tag="new_3980704_3983186_c" /HighExp="Cold, C30, LBGstat, Paraq, GM 120, GM 90, H2O2, Oxctl, GM 25, GM 45" /AntisenseName="yxkI" /AntisenseCor="0.564471040461903" /AntisenseRegPval="-23.3" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1488" downshifts 3430404 /Source="Nicolas_upshifts" /id="D2009" /incds=0 /nref=63 /ntot=147 /MaxReadThrough="2.93791" /MaxDrop="3.97692" /score="3.68725156" /energy="-12.7" /TU="U3053" /idTUdmin="U3053" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3430495..3430514 /Source="Nicolas_upshift_promotors" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3430501 /Source="Nicolas_upshifts" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="upshifts" CDS 3430541..3432229 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_391757.1" /db_xref="EnsemblGenomes-Gn:BSU38780" /db_xref="EnsemblGenomes-Tr:CAB15904" /db_xref="GOA:P94362" /db_xref="InterPro:IPR001915" /db_xref="SubtiList:BG12545" /db_xref="UniProtKB/Swiss-Prot:P94362" /translation="MPMGTHLFLFMLLGLGFYLISALAAKLIPAIDFWIDIVLWVGAA AYIFSHLSFMDGIVSLATMFYCYWTAMDLIVSERVEKPSGDWQEIELAKNKTRLLSDI TLTAIVFAGAVIFFIYGPDTSPLKYVILLGMISGGGALVKRILNVFSVKVFYSAALEK LHISSHYETRTYPLSDLKNIQLESTADLLKLHPLLTMYSSRLDLTTSFQQVIKLSLPG ETLFLTVKEPQKWKTILQEYTDAENNVDNVISVLPFYHRKNVKRLLGKLYFAASVKGV SAYALLVLALYALHASPWVMAVAVILYWVFNMYMSDRVLRAAMDAKSCHHPHVQAAAD KIFRSAGISHVRIYETESDDYNGMAVGMNVGRSMVILTSATLTLPQRVIEGILAHEAI HIKKRDVLSSQLLRFLYLGAVVGIFLLFEQHITHPEAHKIALWAFIMAIIILFQLYQS FCSQWMEVRADNLGASLLDGGYKQMAEALRILAVRQDEDIQKQSAYSSEAGEDELQID SLTRDKSWFFRLIDFQFAPHPPMYWRVGTLLSNKGHGVLKRWLRDRLKESITLK*" /label="yxkI CDS" gene 3430541..3432229 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /label="yxkI gene" promotor_-35 3432227..3432236 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3432248..3432263 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3432252 /Source="Nicolas_upshifts" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="upshifts" CDS 3432287..3432487 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391758.1" /db_xref="EnsemblGenomes-Gn:BSU38790" /db_xref="EnsemblGenomes-Tr:CAB15905" /db_xref="SubtiList:BG14168" /db_xref="UniProtKB/Swiss-Prot:O32284" /translation="MIVIILLFISIIVFLSVIQPQPSKNKSRQQADSGYFGYSDHSSH HDGCSSDGGFSDSGCGGGGGGD*" /label="yxzE CDS" gene 3432287..3432487 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /label="yxzE gene" S_feature 3432488..3433432 /Source="Nicolas_S_feature" /locus_tag="new_3983174_3984118" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T0.0H, T-0.40H, Salt, T3.30H, T3.0H" /AntisenseName="yxkH" /AntisenseCor="0.147753218660366" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1489" CDS complement(3432501..3433340) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported polysaccharide deacetylase, lipoprotein" /protein_id="NP_391759.1" /db_xref="EnsemblGenomes-Gn:BSU38800" /db_xref="EnsemblGenomes-Tr:CAB15906" /db_xref="GOA:P94361" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG12544" /db_xref="UniProtKB/Swiss-Prot:P94361" /translation="MKRLFLSIFLLGSCLALAACADQEANAEQPMPKAEQKKPEKKAV QVQKKEDDTSAWIKTEKPAKLPILMYHSISSGNSLRVPKKEFEAHMKWLHDNGYQTLT PKEASLMLTQDKKPSEKCVLITFDDGYTDNYQDAYPVLKKYGMKATIFMIGKSIGHKH HLTEEQMKEMAQHGISIESHTIDHLELNGLTPQQQQSEMADSKKLFDNMFHQQTTIIS YPVGRYNEETLKAAEKTGYQMGVTTEPGAASRDQGMYALHRVRVSPGMSGSAFGAYIE SMK*" /label="yxkH CDS" gene complement(3432501..3433340) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /label="yxkH gene" promotor_-10 complement(3433366..3433384) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3433384) /Source="Nicolas_upshifts" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3433397..3433404) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3433399 /Source="Nicolas_upshifts" /id="D2010" /incds=0 /nref=27 /ntot=142 /MaxReadThrough="0.40982" /MaxDrop="6.50242" /score="33.6694147" /energy="-13.4" /TU="NA" /idTUdmin="U3055" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(3433447..3434544) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multiple sugar (maltodextrins) transporter ATP-binding protein" /protein_id="NP_391760.1" /db_xref="EnsemblGenomes-Gn:BSU38810" /db_xref="EnsemblGenomes-Tr:CAB15907" /db_xref="GOA:P94360" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005116" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11954" /db_xref="UniProtKB/Swiss-Prot:P94360" /translation="MAELRMEHIYKFYDQKEPAVDDFNLHIADKEFIVFVGPSGCGKS TTLRMVAGLEEISKGDFYIEGKRVNDVAPKDRDIAMVFQNYALYPHMTVYDNIAFGLK LRKMPKPEIKKRVEEAAKILGLEEYLHRKPKALSGGQRQRVALGRAIVRDAKVFLMDE PLSNLDAKLRVQMRAEIIKLHQRLQTTTIYVTHDQTEALTMATRIVVMKDGKIQQIGT PKDVYEFPENVFVGGFIGSPAMNFFKGKLTDGLIKIGSAALTVPEGKMKVLREKGYIG KEVIFGIRPEDIHDELIVVESYKNSSIKAKINVAELLGSEIMIYSQIDNQDFIARIDA RLDIQSGDELTVAFDMNKGHFFDSETEVRIR*" /label="msmX CDS" gene complement(3433447..3434544) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /label="msmX gene" downshifts complement(3433448) /Source="Nicolas_upshifts" /id="D2011" /incds=0 /nref=81 /ntot=171 /MaxReadThrough="3.31232" /MaxDrop="7.04855" /score="29.2689404" /energy="-14.4" /TU="U3057" /idTUdmin="U3058" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3434577..3434596) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3434594) /Source="Nicolas_upshifts" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3434596..3434664) /Source="Nicolas_S_feature" /locus_tag="new_3985282_3985350_c" /HighExp="M0t90, M40t90, Lbstat, Lbtran, T2.0H, dia5, T2.30H, M9-stat, S2, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1490" promotor_-35 complement(3434609..3434616) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3434665..3435558) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10746760" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10746760; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates yxkF-msmX expression)" /protein_id="NP_391761.1" /db_xref="EnsemblGenomes-Gn:BSU38820" /db_xref="EnsemblGenomes-Tr:CAB15908" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12543" /db_xref="UniProtKB/Swiss-Prot:P94359" /translation="MKSLLAIYPGSIVSEELCIREGCLCFFDESNQRYISIPKTEISE KEVLVLQSFLTPADEGNQLSMKSPEENKWFSFLFSRGELPAYIKKRTRFVHFHLFGKI ERTSFTEAVRHFWPVSFVIVWIHEDRGVIVEQESEAAAEKDELESLAKVLESDFYFSV RFYAGRFYEPDECLRKHYAREQAYFLFAEKRLPQVQSVTFEMIFPFLLLETEKEKLET LLSEEAELLFGSESELRKTIKLFIENNSNVTLTAKKLHLHRNSLQYRIDKFIERSGID IKSYKGALLAYFICLQNESSE*" /label="yxkF CDS" gene complement(3434665..3435558) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /label="yxkF gene" promotor_-10 complement(3435585..3435604) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3435604) /Source="Nicolas_upshifts" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3435618..3435625) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3435632..3435637 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3435653..3435671 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3435662 /Source="Nicolas_upshifts" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3435679..3435685 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3435700..3435718 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3435706 /Source="Nicolas_upshifts" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="upshifts" CDS 3435742..3437199 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391762.1" /db_xref="EnsemblGenomes-Gn:BSU38830" /db_xref="EnsemblGenomes-Tr:CAB15909" /db_xref="GOA:P94358" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="PDB:4DNG" /db_xref="SubtiList:BG11903" /db_xref="UniProtKB/Swiss-Prot:P94358" /translation="MSFETLNKSFINGKWTGGESGRTEDILNPYDQSVITTASLATGK QLEDAFDIAQKAQKEWAKSTTEDRKAVLQKARGYLHENRDDIIMMIARETGGTIIKST IELEQTIAILDEAMTYTGELGGVKEVPSDIEGKTNKIYRLPLGVISSISPFNFPMNLS MRSIAPAIALGNSVVHKPDIQTAISGGTIIAKAFEHAGLPAGVLNVMLTDVKEIGDGM LTNPIPRLISFTGSTAVGRHIGEIAGRAFKRMALELGGNNPFAVLSDADVDRAVDAAI FGKFIHQGQICMIINRIIVHQDVYDEFVEKFTARVKQLPYGDQTDPKTVVGPLINERQ IEKALEIIEQAKTDGIELAVEGKRVGNVLTPYVFVGADNNSKIAQTELFAPIATIIKA GSDQEAIDMANDTEYGLSSAVFTSDLEKGEKFALQIDSGMTHVNDQSVNDSPNIAFGG NKASGVGRFGNPWVVEEFTVTKWISIQKQYRKYPF*" /label="aldY CDS" gene 3435742..3437199 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /label="aldY gene" promotor_-10 complement(3436625..3436643) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3436640) /Source="Nicolas_upshifts" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3436658..3436663) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3437180 /Source="Nicolas_upshifts" /id="D2012" /incds=0 /nref=14 /ntot=39 /MaxReadThrough="1.43471" /MaxDrop="4.03346" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 3437224 /Source="Nicolas_upshifts" /id="D2013" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="1.40793" /MaxDrop="3.07407" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(3437241..3438077) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10735877, 10931887, 15096624, 15849754, 16850406, 21317561; Product type t : transporter" /codon_start=1 /transl_table=11 /product="guanidinium exporter" /protein_id="NP_391763.1" /db_xref="EnsemblGenomes-Gn:BSU38840" /db_xref="EnsemblGenomes-Tr:CAB15910" /db_xref="GOA:P94357" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12542" /db_xref="UniProtKB/Swiss-Prot:P94357" /translation="MKKRMLDVLMLVIGAFFFALAVNLFAIPNDLGEGGVTGITLILY YLFQWSPGVTNFILNAFLLLIGYKFLDGKTTVYTIIAVAANSLFLHLTHGWSIPSDEL IINTIFAGVFAGVGIGMIIRVGGTTAGSAILARIANKYLDWNISYALLFFDLIVVFSS YFIIGAEKMMFTIVMLYIGTKVMDFIIEGLNTKKAITVISENKSEIAEQVNTLMDRGV TILSGKGNYTGQSKEILYIVINKQELSMLKKIIRSCDKKAFVIVHDVRDVFGEGFVDI SK*" /label="gdnE CDS" gene complement(3437241..3438077) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /label="gdnE gene" downshifts complement(3437259) /Source="Nicolas_upshifts" /id="D2014" /incds=0 /nref=19 /ntot=137 /MaxReadThrough="1.00689" /MaxDrop="4.07213" /score="21.5028874" /energy="-13.8" /TU="NA" /idTUdmin="U3062" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" misc_RNA complement(3438154..3438256) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /product="guanidine riboswitch (type I)" /experiment="publication(s) with functional evidences, PMID:21317561, 27989440, 28096518" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21317561, 27989440, 28096518" /label="gdwB RNA" gene complement(3438154..3438256) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /label="gdwB gene" downshifts complement(3438180) /Source="Nicolas_upshifts" /id="D2015" /incds=0 /nref=194 /ntot=247 /MaxReadThrough="3.21415" /MaxDrop="5.58394" /score="-0.190335837" /energy="-10.7" /TU="U3062" /idTUdmin="U3065" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3438282..3438301) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3438293) /Source="Nicolas_upshifts" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3438295..3439036) /Source="Nicolas_S_feature" /locus_tag="new_3988981_3989722_c" /HighExp="S6, S8, S7, C30, S5, Gly, C90, Fru, BT, Pyr" /AntisenseName="yxkC" /AntisenseCor="-0.38162570069976298" /AntisenseRegPval="-10" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1491" promotor_-35 complement(3438315..3438321) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3438373..3438380 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3438393..3438411 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3438402 /Source="Nicolas_upshifts" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" S_feature 3438412..3438497 /Source="Nicolas_S_feature" /locus_tag="new_3989098_3989183" /HighExp="Cold, SMM, MG 150, GM 90, Glu, C30, GM 150, GM-0.2, GM 15, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1492" promotor_-35 3438473..3438480 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3438494..3438513 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3438499 /Source="Nicolas_upshifts" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" CDS 3438645..3439187 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818, 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391764.2" /db_xref="EnsemblGenomes-Gn:BSU38850" /db_xref="EnsemblGenomes-Tr:CAB15911" /db_xref="GOA:P94356" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12541" /db_xref="UniProtKB/Swiss-Prot:P94356" /translation="MRHKIITFILAVVVIIIIGNMIGGGGGSEATSKTSSSSKAETEK TYNIGDTVKTEKTEVTVTKVEDRDTVGTQYVEKKASEGGTIVAVQYTIKNVSKKPISS FSIPTVKLVDADGTSYDSDIDASVNYATETKVDNSKILSDLNPNIKVTGVKAFEVDKE AYAKGTWKLKFSNDVIVKIK*" /label="yxkC CDS" gene 3438645..3439187 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /label="yxkC gene" promotor_-10 complement(3439012..3439031) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3439036) /Source="Nicolas_upshifts" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3439045..3439054) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3439177 /Source="Nicolas_upshifts" /id="D2016" /incds=0 /nref=78 /ntot=276 /MaxReadThrough="4.33141" /MaxDrop="6.78221" /score="9.28209494" /energy="-14.4" /TU="U3063,U3064" /idTUdmin="U3064" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" S_feature 3439222..3439544 /Source="Nicolas_S_feature" /locus_tag="new_3989908_3990230" /HighExp="Cold, C30, Heat, Fru, Glu, C90, BMM, Glucon, M/G, Mal" /AntisenseName="galE" /AntisenseCor="0.165797390333391" /AntisenseRegPval="-2.2000000000000002" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1493" CDS complement(3439262..3440281) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /EC_number="5.1.3.7" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1906927, 9555917, 14597172" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906927, 9555917, 14597172; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 4-epimerase" /protein_id="NP_391765.1" /db_xref="EnsemblGenomes-Gn:BSU38860" /db_xref="EnsemblGenomes-Tr:CAB15912" /db_xref="GOA:P55180" /db_xref="InterPro:IPR005886" /db_xref="InterPro:IPR008089" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11837" /db_xref="UniProtKB/Swiss-Prot:P55180" /translation="MAILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRV KEITGKDLTFYEADLLDREAVDSVFAENEIEAVIHFAGLKAVGESVAIPLKYYHNNLT GTFILCEAMEKYGVKKIVFSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILR DLHTADNEWSVALLRYFNPFGAHPSGRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFG NDYPTKDGTGVRDYIHVVDLAEGHVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFE KVSGKEVPYRFADRRPGDIATCFADPAKAKRELGWEAKRGLEEMCADSWRWQSSNVNG YKSAE*" /label="galE CDS" gene complement(3439262..3440281) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /label="galE gene" downshifts complement(3439280) /Source="Nicolas_upshifts" /id="D2017" /incds=0 /nref=235 /ntot=261 /MaxReadThrough="1.7919" /MaxDrop="7.32805" /score="24.6899971" /energy="-14.8" /TU="NA" /idTUdmin="U3066" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3440307..3440326) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3440321) /Source="Nicolas_upshifts" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3440341..3440344) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3440396..3440902) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phospholipid binding protein" /protein_id="NP_391766.1" /db_xref="EnsemblGenomes-Gn:BSU38870" /db_xref="EnsemblGenomes-Tr:CAB15913" /db_xref="InterPro:IPR005247" /db_xref="InterPro:IPR008914" /db_xref="InterPro:IPR036610" /db_xref="SubtiList:BG11899" /db_xref="UniProtKB/Swiss-Prot:P55185" /translation="MNIYVEANPYLHDKYSKYADEKYKREGNPFVSFPIHFDDIPSGA KTLALTFIDHDAIPVCGFSWIHWTAANIPAYIGELPEHASEERQDLMIQGQNSFASPL AGSNDPKVIHQYCGPTPPDKDHAYTLTVYALDAELNLQPGFYLNELYQEMKEHILAET SIELLARV*" /label="yxkA CDS" gene complement(3440396..3440902) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /label="yxkA gene" promotor_-10 complement(3440908..3440927) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3440930) /Source="Nicolas_upshifts" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3440932..3440935 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3440941..3440947) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3440950..3440969 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3440953 /Source="Nicolas_upshifts" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="upshifts" CDS 3441032..3441907 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391767.1" /db_xref="EnsemblGenomes-Gn:BSU38880" /db_xref="EnsemblGenomes-Tr:CAB15914" /db_xref="GOA:P55181" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11898" /db_xref="UniProtKB/Swiss-Prot:P55181" /translation="MDLKWLQTFIAAAESESFREAAEHLYLTQPAVSQHMRKLEDELD MRLFLHSGRRVVLTDEGRLFLPYAKEMIHVYQAGKQKVSQWKQGYSRSLTLAVHPYIA SYILPRFLPAYIQKHPHVELSTHVAGSDAIKQAVEHNEADIGLSRKDPNTNTLYYQHI CEGTLCLAAPFQESRPDAASVLTRYRLLTHDHPSYGDAFLDNIRSHYPYLQMMAVGQT DTAVHMMKAGMGASFLPTYIIKQEEAEKKLMAVSTPAHLELPASQTFMMWKRNSEDIQ HFHAMLHDFMQREQV*" /label="yxjO CDS" gene 3441032..3441907 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /label="yxjO gene" S_feature complement(3441282..3441370) /Source="Nicolas_S_feature" /locus_tag="new_3991968_3992056_c" /HighExp="GM 60, MG-0.1, MG 10, GM 5, S8, T0.30H, BC, S6, GM 15, GM 150" /AntisenseName="yxjO" /AntisenseCor="0.14032494397598999" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0669" /TUlongSig="NA" /TUlongPSig="NA" /label="S1494" downshifts complement(3441304) /Source="Nicolas_upshifts" /id="D2018" /incds=1 /nref=22 /ntot=45 /MaxReadThrough="0.10815" /MaxDrop="6.05884" /score="5.06408541" /energy="-5.6" /TU="NA" /idTUdmin="U3069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3441330..3441430) /Source="Nicolas_upshift_promotors" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3441370) /Source="Nicolas_upshifts" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="upshifts" CDS 3441985..3442458 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391768.1" /db_xref="EnsemblGenomes-Gn:BSU38890" /db_xref="EnsemblGenomes-Tr:CAB15915" /db_xref="GOA:P55182" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR020223" /db_xref="SubtiList:BG11897" /db_xref="UniProtKB/Swiss-Prot:P55182" /translation="MAMSPYIFIVLILIILSMYRERTVKPGKLLIIPLLLLWGVSASF QPAYFHSVLHVAISGILLLIGLACGFGIGKMVNVRIHPETGKVTSRGSLGSVILILVI LSLRMAARTWLPESNEMFIAIIHSMFFVPLGTITARNIMLYKAYRRLTAGKVSIQ*" /label="yxjN CDS" gene 3441985..3442458 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /label="yxjN gene" CDS 3442476..3443696 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxjL]" /protein_id="NP_391769.1" /db_xref="EnsemblGenomes-Gn:BSU38900" /db_xref="EnsemblGenomes-Tr:CAB15916" /db_xref="GOA:P55183" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11896" /db_xref="UniProtKB/Swiss-Prot:P55183" /translation="MNGQTPARHYYKKLVPSLILILNCIQFLSHPTKADPILLAFVFA VYLAFIWIIPYVASTAVSLSIFIGLWLLTDFFWAVSGQEQGAAYFLIVFLMIYAAFRL PSRLSLIFTACLIGGNILLLSSQGGSLNTIISNISIMLGLYVLFSSMRFRREARREAE RNHAELAKMHVQLEHAHKELQKAHAELQEASVLSLRYAVLEERTRIARDIHDSIGHEL TSVIVQLQSLPYILKSSKEDSEKVIQNVLSVARECLQEVRSVVHQMGRSESMVGLTAL RGLIHQVEERSGLHVSLDTAGLSEESWPPNVSETIYRILQEALTNIIRHADASHAAAV ISNDKSHLYVTITDDGQFTGSLTYGFGLTGMKERAEKAGGSLTFSAVQPSGLKIELSL PLMTTNKEQKDEQR*" /label="yxjM CDS" gene 3442476..3443696 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /label="yxjM gene" CDS 3443683..3444339 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YxjM]" /protein_id="NP_391770.1" /db_xref="EnsemblGenomes-Gn:BSU38910" /db_xref="EnsemblGenomes-Tr:CAB15917" /db_xref="GOA:P55184" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11895" /db_xref="UniProtKB/Swiss-Prot:P55184" /translation="MNKDKIRVALADDQPLVREGFRYVINAQTDMTVSGEAGDGHDII ALAKQTKPDVILMDVQMPRCSGIEAAKDIMSALPNTKIVILTTFDTEEYVFEGIRAGA VGYLLKDTLPEELIDAIRAAARGEAIFRTVTAAKIISETFRAKQQTHAEELAEPFTKR ELEVLQQMAYGLRNEDIAEKLFVSESTVKTHVHRILQKCNAQDRTQAVVFAIRNGIVQ *" /label="yxjL CDS" gene 3443683..3444339 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /label="yxjL gene" promotor_-35 3444337..3444342 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3444356..3444375 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3444359 /Source="Nicolas_upshifts" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="upshifts" CDS 3444389..3445621 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /EC_number="3.4.11.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8978088, 10987140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8978088, 10987140; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase T (tripeptidase)" /protein_id="NP_391771.1" /db_xref="EnsemblGenomes-Gn:BSU38920" /db_xref="EnsemblGenomes-Tr:CAB15918" /db_xref="GOA:P55179" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010161" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11842" /db_xref="UniProtKB/Swiss-Prot:P55179" /translation="MKEEIIERFTTYVKVDTQSDESVDTCPSTPGQLTLGNMLVDELK SIGMQDAAIDENGYVMATLPSNTEKDVPTIGFLAHVDTATDFTGKNVNPQIIESYDGK DIVLNEQLQVTLSPDQFPELSGYKGHTLITTDGTTLLGADNKAGIAEIMTAMDYLIKH PEIKHGTIRVAFTPDEEIGRGPHKFDVKRFNASFAYTVDGGPLGELEYESFNAAAAKI TIKGNNVHPGTAKGKMINSAKIAMKLNSLLPADEAPEYTEGYEGFYHLLSIQGDVEET KLHYIIRDFDKENFQNRKETMKRAVEELQNEYGQDRILLDMNDQYYNMREKIEPVIEI VNIAKQAMENLGIEPKISPIRGGTDGSQLSYMGLPTPNIFTGGENFHGKFEYISVDNM VKAVNVIVEIAKQFEAQA*" /label="pepT CDS" gene 3444389..3445621 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /label="pepT gene" downshifts complement(3444406) /Source="Nicolas_upshifts" /id="D2019" /incds=0 /nref=4 /ntot=116 /MaxReadThrough="0.86167" /MaxDrop="3.19485" /score="-2.15704435" /energy="-9.1" /TU="NA" /idTUdmin="U3069" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" downshifts 3445606 /Source="Nicolas_upshifts" /id="D2020" /incds=0 /nref=203 /ntot=244 /MaxReadThrough="3.3949" /MaxDrop="6.35116" /score="27.2051031" /energy="-13.5" /TU="U3070" /idTUdmin="U3070" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 3445667..3445676 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3445689..3445704 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3445691..3445913 /Source="Nicolas_S_feature" /locus_tag="new_3996377_3996599" /HighExp="T-0.40H, T0.30H, T0.0H, T-1.40H, T1.0H, T-1.10H, T3.30H, T2.0H, T1.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.80396299999999998" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1495" upshifts 3445691 /Source="Nicolas_upshifts" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3445870 /Source="Nicolas_upshifts" /id="D2021" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="4.83682" /MaxDrop="4.66302" /score="-1.57383757" /energy="-6.2" /TU="U3071" /idTUdmin="U3070" /TUdmin=242 /isTUend="FALSE" /label="downshifts" promotor_-35 3445924..3445930 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-35" S_feature 3445943..3446043 /Source="Nicolas_S_feature" /locus_tag="new_3996629_3996729" /HighExp="Etha, Gly, Sw, Salt, B60, T0.30H, LoTm, M9-stat, T1.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1496" upshifts 3445943 /Source="Nicolas_upshifts" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="upshifts" promotor_-10 3445945..3445963 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-10" promotor_-35 3446022..3446029 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3446043..3446061 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3446045..3446142 /Source="Nicolas_S_feature" /locus_tag="new_3996731_3996828" /HighExp="Etha, T0.30H, Gly, T1.0H, Sw, Salt, T1.30H, GM 15, B60, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1497" upshifts 3446045 /Source="Nicolas_upshifts" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" CDS 3446143..3446406 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391772.1" /db_xref="EnsemblGenomes-Gn:BSU38930" /db_xref="EnsemblGenomes-Tr:CAB15919" /db_xref="GOA:P94353" /db_xref="SubtiList:BG12540" /db_xref="UniProtKB/Swiss-Prot:P94353" /translation="MLFIDLEFFEYFLAFYPYNREYQNFFWEVCNMILFIIIALCGYL LFSFSKDNRRKPQKTSPLPAAAPHHNNLIDLDAIRQKRRMHLS*" /label="yxjJ CDS" gene 3446143..3446406 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /label="yxjJ gene" promotor_-35 3446170..3446173 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3446188..3446207 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" upshifts 3446200 /Source="Nicolas_upshifts" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3446354 /Source="Nicolas_upshifts" /id="D2022" /incds=0 /nref=4 /ntot=92 /MaxReadThrough="7.33654" /MaxDrop="3.1638" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3446398 /Source="Nicolas_upshifts" /id="D2023" /incds=0 /nref=44 /ntot=188 /MaxReadThrough="5.58502" /MaxDrop="4.5161" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 3446473..3446482 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3446488 /Source="Nicolas_upshifts" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3446494..3446509 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3446535..3447023 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391773.1" /db_xref="EnsemblGenomes-Gn:BSU38940" /db_xref="EnsemblGenomes-Tr:CAB15920" /db_xref="InterPro:IPR007612" /db_xref="InterPro:IPR025659" /db_xref="SubtiList:BG12539" /db_xref="UniProtKB/Swiss-Prot:P94352" /translation="MIELFMKQKMFSFKDAFHIYDRDEQETFKVEGRFFSLGDSLQMT DSSGKTLVSIEQKLMSLLPRYEISIGGKTVCEVTKKVTFSKPKFVISGLNWEIDGDLW RDEFQLTDGENVRMSVSKKWLSWGDSYHLQIAYEEDVLICTAIAIVLDMVLYNDEDES IF*" /label="yxjI CDS" gene 3446535..3447023 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /label="yxjI gene" promotor_-35 3447028..3447035 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3447049..3447068 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3447059 /Source="Nicolas_upshifts" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3447089..3447195 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswI RNA" gene 3447089..3447195 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /label="mswI gene" downshifts 3447190 /Source="Nicolas_upshifts" /id="D2024" /incds=0 /nref=22 /ntot=102 /MaxReadThrough="7.18775" /MaxDrop="3.7896" /score="9.64734237" /energy="-14.5" /TU="U3075,U3076" /idTUdmin="U3072" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3447278..3448411 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyl-tetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391774.2" /db_xref="EnsemblGenomes-Gn:BSU38950" /db_xref="EnsemblGenomes-Tr:CAB15921" /db_xref="GOA:P42319" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11157" /db_xref="UniProtKB/Swiss-Prot:P42319" /translation="MAQQTNVAGQKTEKQRKAPFRADHVGSLLRSVPVKEARQKKAAG EMTAEQLRDIENQEITRIVEKQKEIGLDVVTDGEFRRSWWHYDFLEGLDGVEPFIPAE GIQFHNTKTKARSIKVTGKLDFTSHPALGDYQFLHEIAGNATPKLTIPSPNMLFFGEK ADKGIYDDQEEYFHDMAQAYKKAIKAFYDAGCRYLQLDDTSWSLFFEDKGREVVRALG GDPETLPAIFAKTINDAVADRPDDLTITMHICRGNFRSTWAASGGYDAVAETILDGLN LDGLFLEYDDDRSGNFDPLRFVKRKDLQIVLGLITSKYGELENPEDVKRRINEAARFV SLDQLCLSPQCGFASTEEGNLLTEEQQWAKLRHVIDIANDVWR*" /label="yxjH CDS" gene 3447278..3448411 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /label="yxjH gene" S_feature complement(3447551..3447794) /Source="Nicolas_S_feature" /locus_tag="new_3998237_3998480_c" /HighExp="dia15, Diami, H2O2, dia5, C90, Paraq, Sw, BC, LBGstat, Lbtran" /AntisenseName="yxjH" /AntisenseCor="-0.34694665046491102" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1498" promotor_-10 complement(3447789..3447808) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3447798) /Source="Nicolas_upshifts" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3447823..3447830) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3448417..3448424 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3448439..3448458 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3448445 /Source="Nicolas_upshifts" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3448480..3448586 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswJ RNA" gene 3448480..3448586 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /label="mswJ gene" downshifts 3448533 /Source="Nicolas_upshifts" /id="D2025" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="8.35488" /MaxDrop="3.50346" /score="29.0146782" /energy="-14.5" /TU="U3075,U3076,U3078" /idTUdmin="U3075" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 3448587..3448663 /Source="Nicolas_S_feature" /locus_tag="new_3999273_3999349" /HighExp="MG 5, MG t5, T1.0H, MG 10, T1.30H, BMM, T0.30H, T-0.40H, T0.0H, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigD, SigB, SigWXY" /TUlongPSig="0.554, 1, 1, 1" /label="S1499" CDS 3448664..3449800 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254, 21749987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391775.3" /db_xref="EnsemblGenomes-Gn:BSU38960" /db_xref="EnsemblGenomes-Tr:CAB15922" /db_xref="GOA:P42318" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11156" /db_xref="UniProtKB/Swiss-Prot:P42318" /translation="MSQQTTPAEQKSLQRKKPPFRADQVGSLLRSEPVKKARLQKAAG EMTAEQLRQIENDEIIRIVEKQKETGLNVVTDGEFRRAWWHFDFLENLDGVEPFTPEQ GIQFHNVQTKARGIKVTGDIDFSTHPMLEDYSFLHSIAGDATPKMTIPSPNMLFFRGK LEKDEYKNDYQLFQHDVSKAYKKAIQAFYDRGCRYLQLDDTAWAVFLSEKGLKQIEAF GTTPDELRQLFAKSINDAIADRPDDLTVTMHICRGNFQSTWTAEGGYDAAAETIFDGL NLDGLFLEYDDSRSGGFEPLRYVKRSDLQLVLGLVTSKFGELENPDDVKRRIEEASRY VSLDQLCLSPQCGFASTEEGNKLTEEQQWAKLRHVVEIANDVWK*" /label="yxjG CDS" gene 3448664..3449800 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /label="yxjG gene" downshifts 3449787 /Source="Nicolas_upshifts" /id="D2026" /incds=0 /nref=81 /ntot=187 /MaxReadThrough="4.24668" /MaxDrop="5.8124" /score="11.1243305" /energy="-12.8" /TU="U3076,U3078" /idTUdmin="U3075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3449853..3450626) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacid dehydrogenase" /protein_id="NP_391776.2" /db_xref="EnsemblGenomes-Gn:BSU38970" /db_xref="EnsemblGenomes-Tr:CAB15923" /db_xref="GOA:P42317" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011294" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11155" /db_xref="UniProtKB/Swiss-Prot:P42317" /translation="MRKQVALVTGAAGGIGFEIAREFAREGASVIVSDLRPEACEKAA SKLAEEGFDAAAIPYDVTKEAQVADTVNVIQKQYGRLDILVNNAGIQHVAPIEEFPTD TFEQLIKVMLTAPFIAMKHVFPIMKKQQFGRIINIASVNGLVGFAGKSAYNSAKHGVI GLTKVGALEGAPHGITVNALCPGYVDTQLVRNQLSDLSKTRNVPYDSVLEQVIFPLVP QKRLLSVKEIADYAVFLASEKAKGVTGQAVVLDGGYTAQ*" /label="yxjF CDS" gene complement(3449853..3450626) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /label="yxjF gene" downshifts complement(3449863) /Source="Nicolas_upshifts" /id="D2027" /incds=0 /nref=23 /ntot=63 /MaxReadThrough="0.65" /MaxDrop="6.97604" /score="24.6585594" /energy="-12.8" /TU="NA" /idTUdmin="U3079" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3450643..3451293) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit B)" /protein_id="NP_391777.1" /db_xref="EnsemblGenomes-Gn:BSU38980" /db_xref="EnsemblGenomes-Tr:CAB15924" /db_xref="GOA:P42316" /db_xref="InterPro:IPR004164" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11154" /db_xref="UniProtKB/Swiss-Prot:P42316" /translation="MKEARKRMVKRAVQEIKDGMNVNLGIGMPTLVANEIPDGVHVML QSENGLLGIGPYPLEGTEDADLINAGKETITEVTGASYFDSAESFAMIRGGHIDLAIL GGMEVSEQGDLANWMIPGKMVKGMGGAMDLVNGAKRIVVIMEHVNKHGESKVKKTCSL PLTGQKVVHRLITDLAVFDFVNGRMTLTELQDGVTIEEVYEKTEADFAVSQSVLNS*" /label="scoB CDS" gene complement(3450643..3451293) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /label="scoB gene" CDS complement(3451290..3452006) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit A)" /protein_id="NP_391778.1" /db_xref="EnsemblGenomes-Gn:BSU38990" /db_xref="EnsemblGenomes-Tr:CAB15925" /db_xref="GOA:P42315" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11153" /db_xref="UniProtKB/Swiss-Prot:P42315" /translation="MGKVLSSSKEAAKLIHDGDTLIAGGFGLCGIPEQLILSIRDQGV KDLTVVSNNCGVDDWGLGLLLANKQIKKMIASYVGENKIFERQFLSGELEVELVPQGT LAERIRAGGAGIPGFYTATGVGTSIAEGKEHKTFGGRTYVLERGITGDVAIVKAWKAD TMGNLIFRKTARNFNPIAAMAGKITIAEAEEIVEAGELDPDHIHTPGIYVQHVVLGAS QEKRIEKRTVQQASGKGEAK*" /label="scoA CDS" gene complement(3451290..3452006) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /label="scoA gene" CDS complement(3452030..3453448) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative acid metabolite permease" /protein_id="NP_391779.3" /db_xref="EnsemblGenomes-Gn:BSU39000" /db_xref="EnsemblGenomes-Tr:CAB15926" /db_xref="GOA:P42314" /db_xref="SubtiList:BG11152" /db_xref="UniProtKB/Swiss-Prot:P42314" /translation="MELIIILLALGLLMFTAYRGFSVILFAPICALFAVLLTDPSHVL PFFSSIFMEKMAGFIKLYFPVFLLGAIFGKVVEMAGLAASIAKTIVRLVGAKRAILAI VLMGAVLTYSGVSLFVVVFAVYPFAKNMFQEANIPKRLIPGTIALGAFTFTMDALPGT PQIQNVIPTSFFKTDIYAAPWLGLMGAVIVLAAGMLYLESRRKKAQASGEGYGGFDSQ NAPAPESIESAAEPDKSPIRHALAFVPLILVGAVNKYFTIYLPKWYPNGFDFSSIGLK EFGRLDISSAAAIWSVEIALVIGIITTILFDWRSVFAQLKEGLNEGIGGALLASMNTG AEYGFGGIIAALPGFHKLSSGISHTFTDPLVNGAVTTTALAGITGSASGGMGIALSAM SEQYLQAIQAYNIPPEVMHRVISMASGGMDTLPHNGAVITLLAVTGLTHRQSYRDIFA ITLIKTAAVFAVIAIYSLTGLV*" /label="yxjC CDS" gene complement(3452030..3453448) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /label="yxjC gene" promotor_-10 complement(3452616..3452634) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3452635) /Source="Nicolas_upshifts" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3452650..3452655) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3453449..3453533) /Source="Nicolas_S_feature" /locus_tag="new_4004135_4004219_c" /HighExp="S5, S4, S6, S3, S7, M9-stat, B60, S8, T4.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1500" promotor_-10 complement(3453517..3453535) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3453533) /Source="Nicolas_upshifts" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3453551..3453556) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3453602..3454450) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /EC_number="2.1.1.188" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11967079, 14999102, 18406425, 23716046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m(1)G748 methyltransferase (class II)" /protein_id="NP_391780.1" /db_xref="EnsemblGenomes-Gn:BSU39010" /db_xref="EnsemblGenomes-Tr:CAB15927" /db_xref="GOA:P42313" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR016718" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11151" /db_xref="UniProtKB/Swiss-Prot:P42313" /translation="MKRTVDFSMFRCPLCDSSMDAASGKSLICTERGHTFDLSRHGYV NFLTKPVKTSYGAELFEARSRLIGECGFFDPLHDAIAELISHPKSGHEAFTILDSGCG EGSHLNALCGFDYAGKAAIGTGIDLSKDGILKASKAFKDLMWAVADVARAPFHDRQFD VVLSIFSPSNYAEFHRLLKNDGMLIKVVPRSDYLIELRQFLYTDSPRRTYSNTAAVER FTANAAHSRPVRLRYVKTLDQQAIHWLLKMTPLAWSAPKDRVSLLKEMKSADITVDVD ILIGMK*" /label="rlmA CDS" gene complement(3453602..3454450) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /label="rlmA gene" downshifts complement(3453612) /Source="Nicolas_upshifts" /id="D2028" /incds=0 /nref=54 /ntot=218 /MaxReadThrough="1.618" /MaxDrop="4.63737" /score="17.0758624" /energy="-15.1" /TU="NA" /idTUdmin="U3081" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(3454451..3454636) /Source="Nicolas_S_feature" /locus_tag="new_4005137_4005322_c" /HighExp="B60, LBGstat, LPhT, M9-stat, C30, T0.30H, HPh, Oxctl, Heat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1501" promotor_-10 complement(3454625..3454644) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3454636) /Source="Nicolas_upshifts" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3454638..3455363) /Source="Nicolas_S_feature" /locus_tag="new_4005324_4006049_c" /HighExp="LBGstat, C30, GM 25, Heat, GM 10, GM 45, GM 60, GM 90, T0.30H, GM 120" /AntisenseName="NA" /AntisenseCor="0.20859849915331599" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1502" promotor_-35 complement(3454660..3454664) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3454798..3454805 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3454818..3454837 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3454827 /Source="Nicolas_upshifts" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3454837..3454939 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswB RNA" gene 3454837..3454939 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /label="gswB gene" S_feature 3454940..3455043 /Source="Nicolas_S_feature" /locus_tag="new_4005626_4005729" /HighExp="C90, G180, M40t45, dia15, LBGexp, Lbexp, Lbtran, G135, Mt0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1503" promotor_-35 3455015..3455021 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3455035..3455046 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3455045 /Source="Nicolas_upshifts" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="upshifts" CDS 3455066..3456259 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12787499, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="purine nucleoside transporter" /protein_id="NP_391781.2" /db_xref="EnsemblGenomes-Gn:BSU39020" /db_xref="EnsemblGenomes-Tr:CAB15928" /db_xref="GOA:P42312" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG11150" /db_xref="UniProtKB/Swiss-Prot:P42312" /translation="MYFLLNLVGLIVIMAVVFLCSPQKKKIKWRPIITLIVLELLITW FMLGTKVGSWAIGKIGDFFTWLIACASDGIAFAFPSVMANETVDFFFSALLPIIFIVT FFDILTYFGILPWLIDKIGWVISKASRLPKLESFFSIQMMFLGNTEALAVIRQQLTVL SNNRLLTFGLMSMSSISGSIIGSYLSMVPATYVFTAIPLNCLNALIIANLLNPVHVPE DEDIIYTPPKEEKKDFFSTISNSMLVGMNMVIVILAMVIGYVALTSAVNGILGVFVHG LTIQTIFAYLFSPFAFLLGLPVHDAMYVAQLMGMKLATNEFVAMLDLKNNLKSLPPHT VAVATTFLTSFANFSTVGMIYGTYNSILDGEKSTVIGRNVWKLLVSGIAVSLLSAAIV GLFVW*" /label="nupG CDS" gene 3455066..3456259 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /label="nupG gene" promotor_-10 complement(3455350..3455368) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3455366) /Source="Nicolas_upshifts" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3455381..3455388) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3456035 /Source="Nicolas_upshifts" /id="D2029" /incds=1 /nref=1 /ntot=58 /MaxReadThrough="5.88279" /MaxDrop="2.4159" /score="8.04757856" /energy="-16.6" /TU="U3082,U3083" /idTUdmin="U3082" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" downshifts 3456255 /Source="Nicolas_upshifts" /id="D2030" /incds=0 /nref=71 /ntot=204 /MaxReadThrough="2.7474" /MaxDrop="4.05925" /score="8.04757856" /energy="-16.6" /TU="NA" /idTUdmin="U3082" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3456301..3456729) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminus)" /translation="KTKKQANSRALKREYQTSFSVKYNAAGKLSIQTLNYIYSGGAHG LTSVQSFNYDLKAQKRVTLDQILNTKTKVSKTRDYLYSYIKKHDVLFFSDVKKEDITL NRDTMFYFTANGIAIVFGQYDLGPYAAGIRDVQVPASIYQ*" /label="yxiTc CDS" gene complement(3456301..3456729) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /pseudo /label="yxiTc gene" CDS complement(3456730..3456972) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (N-terminus)" /db_xref="PSEUDO:CAB15929.2" /db_xref="SubtiList:BG11149" /db_xref="UniProtKB/Swiss-Prot:P42311" /translation="MKWNNMLKAAGIAVLLFSVFAYAAPSLKAVQAKTPTVSTHTYKK IKELTYPQVHHVGNAAFEKKINQELKAYMNNRIRNT*" /label="yxiTn CDS" gene complement(3456730..3456972) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /pseudo /label="yxiTn gene" S_feature complement(3456973..3457036) /Source="Nicolas_S_feature" /locus_tag="new_4007659_4007722_c" /HighExp="T2.30H, S6, Etha, T3.30H, S5, BT, T3.0H, T4.0H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.942" /TUlongSig="NA" /TUlongPSig="NA" /label="S1504" promotor_-10 complement(3457025..3457040) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3457036) /Source="Nicolas_upshifts" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3457052..3457061) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3457069 /Source="Nicolas_upshifts" /id="D2031" /incds=0 /nref=10 /ntot=69 /MaxReadThrough="0.814549999999999" /MaxDrop="3.89525" /score="14.5338714" /energy="-6.9" /TU="NA" /idTUdmin="U3082" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(3457117..3457407) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391783.2" /db_xref="EnsemblGenomes-Gn:BSU39040" /db_xref="EnsemblGenomes-Tr:CAB15930" /db_xref="SubtiList:BG11148" /db_xref="UniProtKB/Swiss-Prot:P42310" /translation="MNEKQLTEAYERDENMMILVFAQWCVNHDLDPMELYAKAYPQQK LNESLKKTMDDLVVPKHEAEHIPDQTVIAVLEMFGNTDLAQALHEAISGRKQ*" /label="yxiS CDS" gene complement(3457117..3457407) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /label="yxiS gene" downshifts complement(3457123) /Source="Nicolas_upshifts" /id="D2032" /incds=0 /nref=168 /ntot=241 /MaxReadThrough="3.10756" /MaxDrop="6.10709" /score="16.5130207" /energy="-6.9" /TU="NA" /idTUdmin="U3086" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3457432..3457451) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3457449) /Source="Nicolas_upshifts" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3457457..3459517) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7559348, 8931328, 16151211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559348, 8931328, 16151211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catalase 2" /protein_id="NP_391784.2" /db_xref="EnsemblGenomes-Gn:BSU39050" /db_xref="EnsemblGenomes-Tr:CAB15931" /db_xref="GOA:P42234" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024712" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11102" /db_xref="UniProtKB/Swiss-Prot:P42234" /translation="MSDDQNKRVNEHSKDEQLEQYRTDNSGKKMTTNQGLRVSEDEHS LKAGVRGPTLMEDFHFREKMTHFDHERIPERVVHARGFGVHGFFQVYEPMTEYTRAKF LQDPSVKTPVFVRFSTVAGSKGSADTVRDARGFATKFYTEEGNYDLVGNNIPVFFIQD AIKFPDLVHAFKPEPHNEMPQAATAHDTFWDFVANNPESAHMVMWTMSDRGIPRSYRM MEGFGVHTFRFVNEQGKARFVKFHWKPVLGVHSLVWDEAQKIAGKDPDFHRRDLWETI ENGGKVEYELGVQMIDEEDEFKFDFDILDPTKLWPEELVPVKIIGKMTLNRNQDNVFA ETEQVAFHPGNVVPGIDFTNDPLLQGRLFSYTDTQLIRLGGPNFHEIPINRPVCPFHN NQYDGYHRMTINKGPVAYHKNSLQNNDPSPATAEEGGYVHYQEKVEGKKIRQRSDSFN DYYSQAKLFWNSMSPVEKQHIISAFCFEVGKVKSKDVQRQVVDVFSNVDADLAEEIAK GVGVAAPAKRKASKEILTSPALSQARTVKTASTRKVAVLAGNGFHEKELQTVLEALKQ EGITVDIISQNLGYMTSGSGQQLEASGTFLTVDSVLYDAVYAAGGLELKDNKQAMAFI REAYNHYKAIGAANEGIDLLQSSVGTTEGLGIVTAKDEPDYTAFSKAFIDAVAAHRHW DRRI*" /label="katE CDS" gene complement(3457457..3459517) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /label="katE gene" promotor_-35 complement(3457465..3457472) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3459546..3459564) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3459550) /Source="Nicolas_upshifts" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3459579..3459585) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3459610..3459615 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3459629 /Source="Nicolas_upshifts" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3459631..3459649 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3459643..3459717 /Source="Nicolas_S_feature" /locus_tag="new_4010329_4010403" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, LoTm, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1505" CDS 3459718..3460998 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8892821, 11053381, 15849754, 16850406, 18556792" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8892821, 11053381, 15849754, 16850406, 18556792; Product type t : transporter" /codon_start=1 /transl_table=11 /product="secondary transporter of divalent metal ions/citrate complexes" /protein_id="NP_391785.2" /db_xref="EnsemblGenomes-Gn:BSU39060" /db_xref="EnsemblGenomes-Tr:CAB15932" /db_xref="GOA:P42308" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11146" /db_xref="UniProtKB/Swiss-Prot:P42308" /translation="MLAILGFVMMIVFMYLIMSNRLSALIALIVVPIVFALISGFGKD LGEMMIQGVTDLAPTGIMLLFAILYFGIMIDSGLFDPLIAKILSFVKGDPLKIAVGTA VLTMTISLDGDGTTTYMITIAAMLPLYKRLGMNRLVLAGIAMLGSGVMNIIPWGGPTA RVLASLKLDTSEVFTPLIPAMIAGILWVIAVAYILGKKERKRLGVISIDHAPSSDPEA APLKRPALQWFNLLLTVALMAALITSLLPLPVLFMTAFAVALMVNYPNVKEQQKRISA HAGNALNVVSMVFAAGIFTGILSGTKMVDAMAHSLVSLIPDAMGPHLPLITAIVSMPF TFFMSNDAFYFGVLPIIAEAASAYGIDAAEIGRASLLGQPVHLLSPLVPSTYLLVGMA GVSFGDHQKFTIKWAVGTTIVMTIAALLIGIISF*" /label="citH CDS" gene 3459718..3460998 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /label="citH gene" S_feature 3460999..3461138 /Source="Nicolas_S_feature" /locus_tag="new_4011685_4011824" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, BT, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.382965" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1506" downshifts 3461095 /Source="Nicolas_upshifts" /id="D2033" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.69139" /MaxDrop="3.50434" /score="10.8797157" /energy="-9" /TU="NA" /idTUdmin="U3088" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3461156..3461884) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /EC_number="3.2.1.73" /EC_number="3.2.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1369198, 3106158, 7704256, 20600285, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1369198, 3106158, 7704256, 20600285, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,3-1,4 glucanase" /protein_id="NP_391786.1" /db_xref="EnsemblGenomes-Gn:BSU39070" /db_xref="EnsemblGenomes-Tr:CAB15943" /db_xref="GOA:P04957" /db_xref="InterPro:IPR000757" /db_xref="InterPro:IPR008263" /db_xref="InterPro:IPR008264" /db_xref="InterPro:IPR013320" /db_xref="PDB:3O5S" /db_xref="SubtiList:BG10476" /db_xref="UniProtKB/Swiss-Prot:P04957" /translation="MPYLKRVLLLLVTGLFMSLFAVTATASAQTGGSFFDPFNGYNSG FWQKADGYSNGNMFNCTWRANNVSMTSLGEMRLALTSPAYNKFDCGENRSVQTYGYGL YEVRMKPAKNTGIVSSFFTYTGPTDGTPWDEIDIEFLGKDTTKVQFNYYTNGAGNHEK IVDLGFDAANAYHTYAFDWQPNSIKWYVDGQLKHTATNQIPTTPGKIMMNLWNGTGVD EWLGSYNGVNPLYAHYDWVRYTKK*" /label="bglS CDS" gene complement(3461156..3461884) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /label="bglS gene" downshifts complement(3461173) /Source="Nicolas_upshifts" /id="D2034" /incds=0 /nref=64 /ntot=139 /MaxReadThrough="1.52649" /MaxDrop="6.38109" /score="-8.35070051" /energy="-16.3" /TU="NA" /idTUdmin="U3089" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3461915..3461934) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3461926) /Source="Nicolas_upshifts" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3461948..3461955) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3462072..3462179) /Source="Nicolas_S_feature" /locus_tag="new_4012758_4012865_c" /HighExp="Sw, LPhT, T0.30H, M0t90, M9-stat, M40t90, Lbtran, Lbstat, S2, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1507" downshifts complement(3462115) /Source="Nicolas_upshifts" /id="D2035" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="3.35114" /MaxDrop="4.38508" /score="-8.35070051" /energy="-16.3" /TU="U3090,U3091" /idTUdmin="U3091" /TUdmin="-174" /isTUend="FALSE" /label="downshifts" CDS complement(3462180..3463013) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_391787.2" /db_xref="EnsemblGenomes-Gn:BSU39080" /db_xref="EnsemblGenomes-Tr:CAB15944" /db_xref="GOA:P39805" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1H99" /db_xref="PDB:1L1C" /db_xref="PDB:1TLV" /db_xref="SubtiList:BG10474" /db_xref="UniProtKB/Swiss-Prot:P39805" /translation="MKIAKVINNNVISVVNEQGKELVVMGRGLAFQKKSGDDVDEARI EKVFTLDNKDVSEKFKTLLYDIPIECMEVSEEIISYAKLQLGKKLNDSIYVSLTDHIN FAIQRNQKGLDIKNALLWETKRLYKDEFAIGKEALVMVKNKTGVSLPEDEAGFIALHI VNAELNEEMPNIINITKVMQEILSIVKYHFKIEFNEESLHYYRFVTHLKFFAQRLFNG THMESQDDFLLDTVKEKYHRAYECTKKIQTYIEREYEHKLTSDELLYLTIHIERVVKQ A*" /label="licT CDS" gene complement(3462180..3463013) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /label="licT gene" promotor_-10 complement(3463044..3463063) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3463063) /Source="Nicolas_upshifts" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3463077..3463084) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3463109..3463789) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391788.1" /db_xref="EnsemblGenomes-Gn:BSU39090" /db_xref="EnsemblGenomes-Tr:CAB15945" /db_xref="SubtiList:BG11145" /db_xref="UniProtKB/Swiss-Prot:P42307" /translation="MRRIGLCISLLVTVLVMSACESEGEAQMFADCDQKTVKQTAAKP MSSKKKQDFQALASDRQLAIVFSSMIQVSEAFDYGIGNPEYFVRISMTEEEADIAKEN LESIKLENKSLKKQNSEAVALLQKTRNQDMSRIEIQQLTENRAGFFETADSMIKLINQ VTPKNAKKTRQQLDQLKKQYTQYSAESIKIMNSIVKKQKADKASFERHLEALLQKQPG QQVRSELY*" /label="yxiP CDS" gene complement(3463109..3463789) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /label="yxiP gene" promotor_-10 complement(3463836..3463855) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-10" upshifts complement(3463845) /Source="Nicolas_upshifts" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="upshifts" promotor_-35 complement(3463869..3463876) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-35" promotor_-35 3463937..3463940 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3463955..3463974 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3463955 /Source="Nicolas_upshifts" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="upshifts" CDS 3463996..3465282 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12583894, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391789.1" /db_xref="EnsemblGenomes-Gn:BSU39100" /db_xref="EnsemblGenomes-Tr:CAB15946" /db_xref="GOA:P42306" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024671" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11144" /db_xref="UniProtKB/Swiss-Prot:P42306" /translation="MMKRFTKQENSWVLYDWANSAYSIVVTTAVFPLFYKSAAAESGV SAAQSTAYLGYTIAISTFILAMLGPILGTIADYEGCKKKFFGFFVSAGVASTAMLAFI PSEHWLLLLLFYTVSAIGFSGANVFYDAFLVDVTPEKRMNLVSARGFGLGYIGSTIPF IISIAVILLAQAETIPVSVSAASQLSFFITAAWWGLFTIPMIKHVHQRYYIKKEPHIV INSFKRLGQTMKRIRQYRALFLFLLAYFFYIDGVGTIITMSTSYGSDLGIGSSSLLII LFVTQVVAAPFSIIYGKLAERFTGKTMLYVGIVIYMIVCVYAYFMETTLDFWILAMLV ATSQGGIQALSRSYFAKLVPKRHANEFFGFYNIFGKFASIMGPLLIAVTAQLTGKSST AVFSLIILFVIGIVILAFVPEETSTDVSQQQNDLPL*" /label="yxiO CDS" gene 3463996..3465282 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /label="yxiO gene" promotor_-10 complement(3464727..3464745) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3464735) /Source="Nicolas_upshifts" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3464759..3464766) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3465253 /Source="Nicolas_upshifts" /id="D2036" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="2.50578" /MaxDrop="3.06646" /score="-7.45683354" /energy="-16.7" /TU="NA" /idTUdmin="U3092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3465301..3466740) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase for 23S ribosomal RNAmaturation" /protein_id="NP_391790.2" /db_xref="EnsemblGenomes-Gn:BSU39110" /db_xref="EnsemblGenomes-Tr:CAB15947" /db_xref="GOA:P42305" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005580" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028619" /db_xref="PDB:2G0C" /db_xref="PDB:2HJV" /db_xref="PDB:3MOJ" /db_xref="SubtiList:BG11143" /db_xref="UniProtKB/Swiss-Prot:P42305" /translation="MSHFKNYQISHDILRALEGLGYTEPTKVQQSVIPAALERKDLVV KSQTGSGKTASFGIPLCELANWDENKPQALILTPTRELAVQVKEDITNIGRFKRIKAT AVFGKSSFDKQKAELKQKSHIVVGTPGRVLDHIEKGTLPLDRLSYLVIDEADEMLNMG FIEQVEAIIKHLPTERTTMLFSATLPQDIEKLSRQYMQNPEHIEVKAAGLTTRNIEHA VIQVREENKFSLLKDVLMTENPDSCIIFCRTKEHVNQLTDELDDLGYPCDKIHGGMIQ EDRFDVMNEFKRGEYRYLVATDVAARGIDIENISLVINYDLPLEKESYVHRTGRTGRA GNKGKAISFVTAFEKRFLADIEEYIGFEIQKIEAPSQEEVARKKPEFLAKLNDRPESK KDKSEELNKDIMKLYFNGGKKKKIRAVDFVGTIAKIDGVSADDIGIITIMDNASYVEI LNGKGPHVLKVMKNTTVKGKQLKVNKANK*" /label="deaD CDS" gene complement(3465301..3466740) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /label="deaD gene" downshifts complement(3465324) /Source="Nicolas_upshifts" /id="D2037" /incds=0 /nref=200 /ntot=269 /MaxReadThrough="1.50578" /MaxDrop="5.83238" /score="3.28924902" /energy="-18.2" /TU="NA" /idTUdmin="U3095" /TUdmin=5 /isTUend="TRUE" /label="downshifts" misc_feature complement(3466764..3466783) /Source="Nicolas_upshift_promotors" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3466781) /Source="Nicolas_upshifts" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3466822..3467970) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10746760, 25394512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="esterase (lipoprotein)" /protein_id="NP_391791.2" /db_xref="EnsemblGenomes-Gn:BSU39120" /db_xref="EnsemblGenomes-Tr:CAB15948" /db_xref="GOA:P42304" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="PDB:2O14" /db_xref="SubtiList:BG11142" /db_xref="UniProtKB/Swiss-Prot:P42304" /translation="MKKWMAAVFVMMLMLCFGGIENVKAAEPKVYQFDFGSGSMEPGY IGVRASDRYDRSKGYGFQTPENMRDVAASGAGVKSDAVQFLAYGTKSNNTFNVDLPNG LYEVKVTLGNTARASVAAEGVFQVINMTGDGAEDTFQIPVTDGQLNLLVTEGKAGTAF TLSALKIKKLSDQPVTNRTIYVGGDSTVCNYYPLNSSKQAGWGQMLPHYIDKHTFQVR NMASGGQIARGFRNDGQLEAILKYIKPGDYFMLQLGINDTNPKHKESEAEFKEVMRDM IRQVKAKGADVILSTPQGRATDFTSEGIHSSVNRWYRASILALAEEEKTYLIDLNVLS SAYFTSIGPERTLGLYMDGDTLHPNRAGADALARLAVQELKRQGIAGF*" /label="yxiM CDS" gene complement(3466822..3467970) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /label="yxiM gene" promotor_-10 complement(3467997..3468013) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3468013) /Source="Nicolas_upshifts" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3468015..3468099) /Source="Nicolas_S_feature" /locus_tag="new_4018701_4018785_c" /HighExp="T3.30H, T4.0H, T2.30H, T3.0H, T2.0H, T-3.40H, T5.0H, T-2.40H, Lbexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1508" promotor_-35 complement(3468028..3468033) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3468100..3468288) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52710.1" /translation="MRFENISASKLDDLESIDSVALEIVPTDDQWERLRYYVYDEENQ ISFYCGGWDVIKCDKKSH*" /label="yxzI CDS" gene complement(3468100..3468288) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /pseudo /label="yxzI gene" CDS complement(3468319..3468450) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097796.1" /db_xref="EnsemblGenomes-Gn:BSU39139" /db_xref="EnsemblGenomes-Tr:CAX52711" /db_xref="UniProtKB/Swiss-Prot:C0H3T5" /translation="MNITQYEKLKQHLSDEDTGPFTLNEFSFYMKEDDRYIHIPVFE* " /label="yxzJ CDS" gene complement(3468319..3468450) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /label="yxzJ gene" CDS complement(3468462..3468923) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type f: factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391793.1" /db_xref="EnsemblGenomes-Gn:BSU39140" /db_xref="EnsemblGenomes-Tr:CAB15950" /db_xref="SubtiList:BG11140" /db_xref="UniProtKB/Swiss-Prot:P42302" /translation="MEITSISSIGNLDMIELKPDQTVMACELEDAESFYRFWAGLAYD RIMIQVITTGSFIEDLSEYFEGHAYKVTKLAKREFHFQSILQEADRDIADFLFLLASI NDDVFLITDPQPDKSYFSEGKLQCLTDSGERIIWFEYDAVDIYMIGGESYK*" /label="yxiK CDS" gene complement(3468462..3468923) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /label="yxiK gene" CDS complement(3468939..3469235) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391794.1" /db_xref="EnsemblGenomes-Gn:BSU39150" /db_xref="EnsemblGenomes-Tr:CAB15951" /db_xref="InterPro:IPR025551" /db_xref="SubtiList:BG11139" /db_xref="UniProtKB/Swiss-Prot:P42320" /translation="MLQKLRKRQRELEEKQYPDELYGFEAEIYEFFMLVAGSLDYVLA NKRIPRHQRRSLEKSFFELYPDILPDMIKNDKDLYHHILLYEQVRQEICVALSN*" /label="yxiJ CDS" gene complement(3468939..3469235) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /label="yxiJ gene" CDS complement(3469263..3469751) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391795.1" /db_xref="EnsemblGenomes-Gn:BSU39160" /db_xref="EnsemblGenomes-Tr:CAB15952" /db_xref="InterPro:IPR020323" /db_xref="SubtiList:BG11138" /db_xref="UniProtKB/Swiss-Prot:P42301" /translation="MMNWRALSQTKQDRIWSEVNKIIKWKPGSRCHHIIPPDPYRVFD ISSAMSSKAGHNDVSGVLSDLETSILKAFQLGTGKNDVMYALDWQHDGYTFSPHQAMP KDEFGEWPVPVFPNGDYYFFFHQDFSWGLLGDPWKCAITVFGEELLEAIDNDPPILFR NK*" /label="yxiI CDS" gene complement(3469263..3469751) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /label="yxiI gene" CDS complement(3469769..3470221) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391796.1" /db_xref="EnsemblGenomes-Gn:BSU39170" /db_xref="EnsemblGenomes-Tr:CAB15953" /db_xref="SubtiList:BG14170" /db_xref="UniProtKB/Swiss-Prot:O32285" /translation="MWCFTLDGQQKEIHIDRKLEEMDAPAVDDCYGLAEKNGLIYMLY YGDAVIAAFDETVVRRVWILSDKEPDSEAFDQLAISEEGFLVGTFNCYSADLKSSLYL ISADVSQEMEEITCCDSNGEGLDVQQLKLTSYAVYAVASSGVYKQDIQ*" /label="yxzG CDS" gene complement(3469769..3470221) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /label="yxzG gene" S_feature complement(3470222..3470290) /Source="Nicolas_S_feature" /locus_tag="new_4020908_4020976_c" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, T2.0H, T-3.40H, T5.0H, T-2.40H, T-4.40H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19384199999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1509" CDS complement(3470291..3470620) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391797.1" /db_xref="EnsemblGenomes-Gn:BSU39180" /db_xref="EnsemblGenomes-Tr:CAB15954" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11137" /db_xref="UniProtKB/Swiss-Prot:P42300" /translation="MKKLKLNKIINENTQDCFFHADPQGRVYIGKGLKGGITITIYDP SGDVRDFRVKEQISYSDILLFQQCADGYVFVYYESYEPKVKVFSEEGRVKSVFHLPSG VSCCLLD*" /label="yxiH CDS" gene complement(3470291..3470620) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /label="yxiH gene" S_feature complement(3470621..3470742) /Source="Nicolas_S_feature" /locus_tag="new_4021307_4021428_c" /HighExp="T3.30H, T4.0H, T3.0H, T2.30H, T-4.40H, T-3.40H, LBGexp, T-2.40H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1510" CDS complement(3470743..3471159) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391798.1" /db_xref="EnsemblGenomes-Gn:BSU39190" /db_xref="EnsemblGenomes-Tr:CAB15955" /db_xref="SubtiList:BG11136" /db_xref="UniProtKB/Swiss-Prot:P42299" /translation="MTMYQTINEWVDYIDKGCSVLHLDFNVFKKELSLDIKVFEDEGE YTHKISFQNVASAYYSADVGDMRLEKIDPEEYNWQVFEMSYHPEGIGNLSNSIIPEYQ SNANFLIDMNRMLIAIEAETVRFDDQSFYAYQLNTK*" /label="yxiG CDS" gene complement(3470743..3471159) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /label="yxiG gene" CDS complement(3471210..3471578) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391799.1" /db_xref="EnsemblGenomes-Gn:BSU39200" /db_xref="EnsemblGenomes-Tr:CAB15956" /db_xref="SubtiList:BG14167" /db_xref="UniProtKB/Swiss-Prot:O32286" /translation="MVDWKPFGTYLLRKKLQYLNISTVLCILIKNHLVLEYVVIKLSE TNLIECINKIKSVLNGQTTREEVSDWAGTYVYADDPEVEDDRVWDMLILLSGIDLKDS SETYLHSTDDLNDWIKQYTE*" /label="yxzC CDS" gene complement(3471210..3471578) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /label="yxzC gene" CDS complement(3471572..3472042) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391800.1" /db_xref="EnsemblGenomes-Gn:BSU39210" /db_xref="EnsemblGenomes-Tr:CAB15957" /db_xref="SubtiList:BG11135" /db_xref="UniProtKB/Swiss-Prot:P42298" /translation="MQKRLIEKLAENKRRLLMSEIKEKLVPCAERGFTYRFADLAQSR QLLELVLSNSIPANTREVDALEKTEAKQLIWKISQSYVAYDDRDVLLFHQYSSEIGAL VCSFGKCLEHLDCLLECIEFDEGILNHSFILVEPKCQFGLCILHTEYGCELVYW*" /label="yxiF CDS" gene complement(3471572..3472042) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /label="yxiF gene" S_feature complement(3472043..3472367) /Source="Nicolas_S_feature" /locus_tag="new_4022729_4023053_c" /HighExp="T3.30H, T-2.40H, T2.30H, T3.0H, T4.0H, SMMPr, MG 120, C90, T2.0H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1511" CDS complement(3472368..3472796) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /experiment="publication(s) with functional evidences, PMID:1529529, 16306698, 19763274, 23572593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1529529, 16306698, 19763274, 23572593; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin of WapA tRNase" /protein_id="NP_391801.1" /db_xref="EnsemblGenomes-Gn:BSU39220" /db_xref="EnsemblGenomes-Tr:CAB15958" /db_xref="SubtiList:BG10798" /db_xref="UniProtKB/Swiss-Prot:Q07836" /translation="MAKIKDDCIELELTPRRYQELDDDPFILSVFELLENKKAVVRDF SAVLLESEYKVLISGIETMIKGNQDSISLETIEPFLFLSIDQENGNYRIKIKIIFDDY KESKSNSNLFEINCNEEKLESFVTALKLNLENTKNPSKLP*" /label="wapI CDS" gene complement(3472368..3472796) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /label="wapI gene" CDS complement(3472858..3479862) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated tRNA nuclease precursor; intercellular growth inhibitor" /protein_id="NP_391802.2" /db_xref="EnsemblGenomes-Gn:BSU39230" /db_xref="EnsemblGenomes-Tr:CAB15959" /db_xref="GOA:Q07833" /db_xref="InterPro:IPR006530" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR022385" /db_xref="InterPro:IPR031325" /db_xref="SubtiList:BG10797" /db_xref="UniProtKB/Swiss-Prot:Q07833" /translation="MKKRKRRNFKRFIAAFLVLALMISLVPADVLAKSTEEENGNRIA ADDPEETLQKEQTEEAVPFDPKDINKEGEITSERTENTKLYYEGDGVYKQEVYLDPIH TKETPDADWEDISPELKESTSKQVETENAILNSDFQKQMKNGLYATFEHNDHKVTYSL AEAKGPNKTSLTPKDTSADYKTDSNEIVYPDVFPNIDLQTFTFNENIKEDLVLHQYNG YNTFTFQLKTDLQAKEQEDGSIDFSDEKGKVVFSVPKPFMTDSKLDELSGEVERSDKV SYKLEKNEEGYLLHLTADENWLKDPERVYPVSIDPSTSLSVSSDTFVMSAYPTTNYSA SSQKWDANLKAYVLKTGYYDKTTGTNYAFMKFNNLKPIQNMTVTKATLKTYVAHSYYG TKATGLWLDTVNSNYDNAKVTWNTKPASKNIGKADVHKGQWASYDVTAAVKSWNSGGA NYGFKLHTNGNGKEYWKKLISSANSANKPYIEVTYTIPKGNTPTIKAYHNGDSTGYFD ISWKKVEGAKGYKVWIYNGKEYQAISAGNVTSWSTKGKKIWPTSAEIASKRYKLHLDG KDGAELALDPSPVYKNSGGSYATSKNYWIGVSAIFDQGEGAMSAPAKPVIPNVGKAQA PSAKGYNNGNATGYFDLSWKAVSGATGYKVQVFNGKGFETLDLGNQTSWTTKGKKIWP TSAEIKAGKYALHLKDGSGAELPINPGPTYKNAGGDGAKRNYSFKIIAYNKDGEAIAS PAATPALPDIARPKNVTGYLYTNTKSSQTGYVNLIWEKVQNAKGYKVNIYNGKEYQSF DVGDADHWTTQNKNIWPTSEEIKAGSYKLHTDGKGGELALDPSPVYNNANGNYKGKKN YSFTLVAYDANGETIPTAPFNPTFHEGAEFLGTEEYWSIIDIPSGQLNGATGNVIVNE EDLSIDGRGPGLGLSRTYNSLDSSDHLFGQGWYADAETSVISTDGGAMYIDEDATTHR FTKKADGTYQPPTGVYLELTETADQFILKTKDQTNAYFNKKGGKLQKVVDGHNNATVY TYNDKNQLTAITDASGRKLTFTYDENGHVTSITGPKNKKVTYSYENDLLKKVTDTDGT VTSYDYDSEGRLVKQYSANSTEAKPVFTEYQYSGHRLEKAINAKKETYVYSYDADKKT LLMTQPNGRKVQYGYNEAGNPIQVIDDAEGLKITTNTKYEGNNVVEDVDPNDVGTGKA TESYQYDKDGNVTSVKDAYGTETYEYNKNNDVTKMKDTEGNVTDIAYDGLDAVSETDQ SGKSSSAAVYDKYGNQIQSSKDLSASTNILKDGSFEAQKSGWNLTASKDSGKISVIAD KSGVLSGSKALEVLSQSTSAGTDHGYSSATQTVELEPNTTYTLSGKIKTDLAKSRAYF NIDLRDKDQKRIQWIHNEYSALAGKNDWTKRQITFTTPANAGKAVVYMEVDHKDKDGK GKAWFDEVQLEKGEVSSSYNPVQNSSFTSATENWNVSGASVDSEEGFNDDVSLKAART SASQAGSVTKQTVVLGQSANDKPVYLTLTGMSKASSVKFTDEKDYSLQANVTYADGST GIYNAKFPSGTQEWNRAAVVIPKTKPINKVDISILFQKSATGTVWFDDIRLIEGSLLT KSTYDSNGNYVTKEEDELGYATSTDYDETGKKTSETDAKGEKTTYTYDQADQLTNMTL SNGTSILHSYDKEGNEVSKTIRAGADQTYKFEYDVMGKLVKTTDPLGNVLASEYDANS NLTKTISPNGNEVSLSYDGTDRVKSKSYNGTEKYIFTYDKNGNETSVVNKEQNTTKKR TFDNKNRLTELTDRGGSQTWTYPSDSDKLKTFSWIHGDQKGTNQFTYNKLDQMIEMKD STSSYSFDYDENGNVQTFITGNGGGTSFSYDERNLVSSLHIGDKNGGDILTESYEYDA NGNRTTINSSASGKVQYEYGKLNQLVKETHEDGTVIEYTYDGFGNRKTVTTIKDGSSK TVNASFNIMNQLTKVNDESISYDKNGNRTSDGKFTYTWDAEDNLTAVTKKGEDKPFAT YKYDEKGNRIQKTVNGKVTNYFYDGDSLNVLYETDADNNVTKSYTYGDSGQLLSYTEN GKKYFYHYNAHGDIIAISDSTGKTVAKYQYDAWGNPTKTEASDEVKDNRYRYAGYQYD EETGLYYLMARYYEPRNGVFLSLDPDPGSDGDSLDQNGYAYGNNNPVMNVDPDGHWVW LVVNAGFAAYDGYKAYKSGKGWKGAAWAAASNFGPGKIFKGASRAYKFTKKAVKITGH TRHGLNQSIGRNGGRGVNLRAKLNAVRSPKKVIKQPNGATKYVGKKATVVLNKRGKVI TAYGSSRAKGSKHVFHTHGKGNKSKRRR*" /label="wapA CDS" gene complement(3472858..3479862) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /label="wapA gene" misc_feature 3479869..3479883 /Source="Nicolas_upshift_promotors" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3479883 /Source="Nicolas_upshifts" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3479893..3479912) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3479908) /Source="Nicolas_upshifts" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3479927..3479934) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3480024..3480959) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391803.1" /db_xref="EnsemblGenomes-Gn:BSU39240" /db_xref="EnsemblGenomes-Tr:CAB15960" /db_xref="GOA:Q07835" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10796" /db_xref="UniProtKB/Swiss-Prot:Q07835" /translation="MQQDPSISSKQKSTAVIKMVISMVIFGSIGFFSEHTNLPSFELV FVRCLCATLFLGFCWLASGQYKTEKWSKRDVLQTLACGFFLVFNWVFLFKSFEETSVT IAISVYHLAPVLVLLLGSFFYREKLNVISVSSIIICFLGTALISGINGSTSLTQLMGS GIIWAVLAALFYAFTTLLGKGIHNLSPYTTTFLQTGLGVIILIPFIHFGAFADLSQGN WIMVVSTGIIHTGIVYLLFFDSLRFLSTKFISIIVFLDPAVAIVLDTVFTGFRPDLYQ TLGIVMIFAGMALTLVRRQGKANVTAEGTDIEQIQ*" /label="yxxF CDS" gene complement(3480024..3480959) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /label="yxxF gene" downshifts complement(3480245) /Source="Nicolas_upshifts" /id="D2038" /incds=1 /nref=1 /ntot=153 /MaxReadThrough="1.33481" /MaxDrop="2.42407" /score="29.0290332" /energy="-5.9" /TU="NA" /idTUdmin="U3098" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(3480960..3481080) /Source="Nicolas_S_feature" /locus_tag="new_4031646_4031766_c" /HighExp="T3.0H, T1.0H, T3.30H, LBGstat, T1.30H, T0.30H, T4.0H, M9-stat, T2.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="Sig-" /TUlongPSig="0.196" /label="S1512" CDS complement(3481111..3481557) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10913081, 12644671, 17210127" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 12644671, 17210127; Product type f: factor" /codon_start=1 /transl_table=11 /product="phosphate starvation protein (universal stress protein A family)" /protein_id="NP_391804.1" /db_xref="EnsemblGenomes-Gn:BSU39250" /db_xref="EnsemblGenomes-Tr:CAB15961" /db_xref="GOA:P42297" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11134" /db_xref="UniProtKB/Swiss-Prot:P42297" /translation="MFNKMLVAIDGSDMSAKALDAAVHLAKEQQAELSILHVGREAVV TTSSLTGIVYVPEHFIDEIRNEVKKEGLKILENAKEKAAEKGVQAETIYANGEPAHEI LNHAKEKGVSLIVVGSRGISGLKEMMLGSVSHKVSQLSTCPVLIVR*" /label="yxiE CDS" gene complement(3481111..3481557) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /label="yxiE gene" downshifts complement(3481125) /Source="Nicolas_upshifts" /id="D2039" /incds=0 /nref=22 /ntot=144 /MaxReadThrough="4.33955" /MaxDrop="6.75522" /score="45.6082379" /energy="-8.4" /TU="U3098" /idTUdmin="U3099" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3481594..3481613) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3481601) /Source="Nicolas_upshifts" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3481627..3481634) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3481660..3483069) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_391805.2" /db_xref="EnsemblGenomes-Gn:BSU39260" /db_xref="EnsemblGenomes-Tr:CAB15962" /db_xref="GOA:P40740" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG10935" /db_xref="UniProtKB/Swiss-Prot:P40740" /translation="MSSNEKRFPEGFLWGGAVAANQVEGAYNEGGKGLSTADVSPNGI MSPFDESMTSLNLYHNGIDFYHRYKEDIALFAEMGFKAFRTSIAWTRIFPNGDEEEPN EEGLRFYDDLFDELLKHHIEPVVTISHYEMPLGLVKNYGGWKNRKVIEFYERYAKTVF KRYQHKVKYWMTFNEINVVLHAPFTGGGLVFEEGENKLNAMYQAAHHQFVASALAVKA GHDIIPDSKIGCMIAATTTYPMTSKPEDVFAAMENERKTLFFSDVQARGAYPGYMKRY LAENNIEIEMAEGDEELLKEHTVDYIGFSYYMSMAASTDPEELAKSGGNLLGGVKNPY LKSSEWGWQIDPKGLRITLNTLYDRYQKPLFIVENGLGAVDKVEEDGTIQDDYRINYL RDHLIEAREAIADGVELIGYTSWGPIDLVSASTAEMKKRYGFIYVDRDNEGNGTFNRI KKKSFNWYQQVIATNGESL*" /label="bglH CDS" gene complement(3481660..3483069) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /label="bglH gene" CDS complement(3483092..3484921) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /EC_number="2.7.1.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17074746, 8626332" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17074746, 8626332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) beta-glucoside-specific enzyme IIBCA component" /protein_id="NP_391806.2" /db_xref="EnsemblGenomes-Gn:BSU39270" /db_xref="EnsemblGenomes-Tr:CAB15963" /db_xref="GOA:P40739" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011297" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10934" /db_xref="UniProtKB/Swiss-Prot:P40739" /translation="MDYDKLSKDILQLVGGEENVQRVIHCMTRLRFNLHDNAKADRSQ LEQLPGVMGTNISGEQFQIIIGNDVPKVYQAIVRHSNLSDEKSAGSSSQKKNVLSAVF DVISGVFTPILPAIAGAGMIKGLVALAVTFGWMAEKSQVHVILTAVGDGAFYFLPLLL AMSAARKFGSNPYVAAAIAAAILHPDLTALLGAGKPISFIGLPVTAATYSSTVIPILL SIWIASYVEKWIDRFTHASLKLIVVPTFTLLIVVPLTLITVGPLGAILGEYLSSGVNY LFDHAGLVAMILLAGTFSLIIMTGMHYAFVPIMINNIAQNGHDYLLPAMFLANMGQAG ASFAVFLRSRNKKFKSLALTTSITALMGITEPAMYGVNMRLKKPFAAALIGGAAGGAF YGMTGVASYIVGGNAGLPSIPVFIGPTFIYAMIGLVIAFAAGTAAAYLLGFEDVPSDG SQQPAVHEGSREIIHSPIKGEVKALSEVKDGVFSAGVMGKGFAIEPEEGEVVSPVRGS VTTIFKTKHAIGITSDQGAEILIHIGLDTVKLEGQWFTAHIKEGDKVAPGDPLVSFDL EQIKAAGYDVITPVIVTNTDQYSFSPVKEIGKVQPKEALLALS*" /label="bglP CDS" gene complement(3483092..3484921) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /label="bglP gene" promotor_no_box complement(3484913..3485013) /Source="Nicolas_upshift_promotors" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="promotor_no_box" upshifts complement(3484953) /Source="Nicolas_upshifts" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="upshifts" S_feature complement(3484955..3485147) /Source="Nicolas_S_feature" /locus_tag="new_4035641_4035833_c" /HighExp="Diami, T0.30H, B60, T0.0H, G150, M9-stat, T1.0H, T1.30H, Gly, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29980099999999998" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.998, 0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1513" promotor_-10 complement(3485128..3485147) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3485147) /Source="Nicolas_upshifts" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3485149..3485282) /Source="Nicolas_S_feature" /locus_tag="new_4035835_4035968_c" /HighExp="S2, HiTm, Sw, S8, M9-stat, Lbstat, S0, T2.0H, Mal, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1514" promotor_-35 complement(3485160..3485167) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3485304..3485612) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391807.1" /db_xref="EnsemblGenomes-Gn:BSU39280" /db_xref="EnsemblGenomes-Tr:CAB15964" /db_xref="SubtiList:BG11071" /db_xref="UniProtKB/Swiss-Prot:P40738" /translation="MLLINKQKDPVFQFLAGTFHQDIETPDDAIQELLIEESKEYLED AIVFLTDFIESEHSDNKKNDYIQSCADGVYLPAFNLEPIDWLKNVIVQIKKSLKKFKR *" /label="yxxE CDS" gene complement(3485304..3485612) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /label="yxxE gene" downshifts complement(3485327) /Source="Nicolas_upshifts" /id="D2040" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.99098" /MaxDrop="5.76651" /score="24.0715465" /energy="-21.3" /TU="U3101,U3102" /idTUdmin="U3101" /TUdmin="-3718" /isTUend="FALSE" /label="downshifts" CDS complement(3485658..3486101) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin factor of the RttD-RttE toxin-antitoxin system" /protein_id="NP_391808.1" /db_xref="EnsemblGenomes-Gn:BSU39290" /db_xref="EnsemblGenomes-Tr:CAB15965" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG11070" /db_xref="UniProtKB/Swiss-Prot:P40737" /translation="MSYNFIKSNKENDFYPVNQSEIEEVEKNLNLKLPSELVNFYLEV GYGFIKGSEFNTNRILDPYSVRDFRLRINDFEFYPDIEIYDEFENDKLIFFEGSESAL MSIELNDNNKNPIYYYDIQIATSLTEFLRKIEENDQYYLDLLDDE*" /label="rtbE CDS" gene complement(3485658..3486101) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /label="rtbE gene" CDS complement(3486098..3487807) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease toxin of the RtbD-RtbE toxin-antitoxin system" /protein_id="NP_391809.2" /db_xref="EnsemblGenomes-Gn:BSU39300" /db_xref="EnsemblGenomes-Tr:CAB15966" /db_xref="GOA:P42296" /db_xref="InterPro:IPR003615" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG11133" /db_xref="UniProtKB/Swiss-Prot:P42296" /translation="MKTLDVHALHEGIQHTIEKLDKQKQQLEKLEKSVEHLAGMKDAL KGKGGDAIRTFYEECHKPFLLFFGIFIDEYKKVLKQTQHAISSVESNSHGMIAEAFLS HDARHGVKHAREVTEQLTDAVNRQTSAIDHIVSLPTVNDSFFRMETEQAERLISDTLN KLFQFDGQQTQALEAAKSDFQTMKKYIDQLETMYTGPKIEITGYKSGSILKSQEEENI NQIFGAINPQMKQADDSPMEMMLKKLAENEKSKVDSVVKTGDSKKVSKNIIVINGKVY NTSEHREHIKTDFSNAEVKQVVYNDTLYNVYISGNDMKLEPVVSLSDIKVDENGYVKI LETAVELTGVYDLFKAATGRDPVSGEKVTGKDRVVASINSVPFAKIAKLEKLIDINKL INNGKKAKKASEVKNVAKDKGKIANDVSGSANKINSDLIKKYARDIEQRTGRELPKNQ IDKLKEALRNKEYKKMSPIETAKHRTKFDKVKNKVIKEWEENTGQKWPVYKENVVSEK TGKIIRKKGDKYDAHHIIENTFGGEHEWWNMHPAKFPNEHQAGIHGTGSPANELFKGG KKK*" /label="rtbD CDS" gene complement(3486098..3487807) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /label="rtbD gene" misc_feature complement(3486969..3486988) /Source="Nicolas_upshift_promotors" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3486977) /Source="Nicolas_upshifts" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="upshifts" CDS complement(3487827..3488096) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391810.1" /db_xref="EnsemblGenomes-Gn:BSU39310" /db_xref="EnsemblGenomes-Tr:CAB15967" /db_xref="InterPro:IPR020315" /db_xref="SubtiList:BG11132" /db_xref="UniProtKB/Swiss-Prot:P42295" /translation="MAQEIKMVYDTVKQGLSQLKNSAELKSSLPGHLSGRNHLNVVKS IEQLNKDIKELTEAYASVLAKHIAQTESAVNAMKETDENISSSMK*" /label="yxiC CDS" gene complement(3487827..3488096) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /label="yxiC gene" CDS complement(3488108..3488473) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391811.1" /db_xref="EnsemblGenomes-Gn:BSU39320" /db_xref="EnsemblGenomes-Tr:CAB15968" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG11131" /db_xref="UniProtKB/Swiss-Prot:P42294" /translation="MHSEMLLHSVKADLHEKQEQIHQLKRVLHEIRQIKHDFSEAQHL IHRPHLNREAWRGTHAERFEDIREGMNKAYQQIKSDQVSGIIESIEGKIHSLEGDVYS IRRQITRIEHEIEKEKHKK*" /label="yxiB CDS" gene complement(3488108..3488473) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /label="yxiB gene" S_feature complement(3488474..3488539) /Source="Nicolas_S_feature" /locus_tag="new_4039160_4039225_c" /HighExp="T-1.40H, T-3.40H, T2.30H, T-2.40H, T-0.40H, T1.0H, T-1.10H, T-5.40H, T3.30H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1515" promotor_-10 complement(3488526..3488545) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3488539) /Source="Nicolas_upshifts" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3488560..3488563) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3488780..3490189) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 18408032, 18607095, 20883454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 18408032, 18607095, 20883454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan endo-1,5-alpha-L-arabinosidase ([Ca(2+)-dependent]" /protein_id="NP_391812.2" /db_xref="EnsemblGenomes-Gn:BSU39330" /db_xref="EnsemblGenomes-Tr:CAB15969" /db_xref="GOA:P42293" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR023296" /db_xref="InterPro:IPR032291" /db_xref="PDB:2X8F" /db_xref="PDB:2X8S" /db_xref="PDB:2X8T" /db_xref="PDB:4COT" /db_xref="SubtiList:BG11130" /db_xref="UniProtKB/Swiss-Prot:P42293" /translation="MFNRLFRVCFLAALIMAFTLPNSVYAQKPIFKEVSVHDPSIIET NGTFYVFGSHLASAKSNDLMQWQQLTTSVSNDNPLIPNVYEELKETFEWAQSDTLWAA DVTQLADGKYYMYYNACRGDSPRSAMGVAVADNIEGPYKNKGIFLKSGMEGTSSDGTP YDATKHPNVVDPHTFFDKDGKLWMVYGSYSGGIFILEMNPKTGFPLPGQGYGKKLLGG NHSRIEGPYVLYNPDTQYYYLYLSYGGLDATGGYNIRVARSKKPDGPYYDAEGNPMLD VRGKGGTFFDDRSIEPYGVKLMGSYTFETENEKGTGYVSPGHNSAYYDEKTGRSYLIF HTRFPGRGEEHEVRVHQLFMNKDGWPVAAPYRYAGETLKEVKQKDITGTYKLIQHGKD ISADIKQTINIQLNKNHTISGEMTGTWRKTGKNTADITLAGKKYNGVFLRQWDSVREK NVMTFSVLNTSGEAVWGSK*" /label="abnB CDS" gene complement(3488780..3490189) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /label="abnB gene" downshifts complement(3488803) /Source="Nicolas_upshifts" /id="D2041" /incds=0 /nref=2 /ntot=38 /MaxReadThrough="0.825980000000001" /MaxDrop="3.49689" /score="16.962389" /energy="-7.9" /TU="NA" /idTUdmin="U3101" /TUdmin="-7194" /isTUend="FALSE" /label="downshifts" S_feature complement(3490190..3490299) /Source="Nicolas_S_feature" /locus_tag="new_4040876_4040985_c" /HighExp="S2, T2.30H, BC, T2.0H, M9-stat, T3.0H, T3.30H, T4.0H, S1, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1516" CDS complement(3490323..3490487) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097797.1" /db_xref="EnsemblGenomes-Gn:BSU39339" /db_xref="EnsemblGenomes-Tr:CAX52712" /db_xref="UniProtKB/Swiss-Prot:C0H3T6" /translation="MAVSQLMQNLTKQLLHVRERKTDVMQEGETAKELNYEGEDMQAT SSAQNRQTSV*" /label="yxzL CDS" gene complement(3490323..3490487) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /label="yxzL gene" promotor_-10 complement(3490372..3490390) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3490387) /Source="Nicolas_upshifts" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3490401..3490409) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3490679..3490698) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3490695) /Source="Nicolas_upshifts" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3490711..3490718) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3490727..3490734 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3490749..3490768 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3490752 /Source="Nicolas_upshifts" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="upshifts" CDS 3490806..3491252 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391813.2" /db_xref="EnsemblGenomes-Gn:BSU39340" /db_xref="EnsemblGenomes-Tr:CAB15970" /db_xref="GOA:P10943" /db_xref="InterPro:IPR015111" /db_xref="InterPro:IPR023552" /db_xref="InterPro:IPR036482" /db_xref="PDB:1VEA" /db_xref="PDB:1WMQ" /db_xref="PDB:1WPS" /db_xref="PDB:1WPT" /db_xref="PDB:1WPU" /db_xref="PDB:1WPV" /db_xref="PDB:1WRN" /db_xref="PDB:1WRO" /db_xref="PDB:1WRQ" /db_xref="PDB:3BOY" /db_xref="PDB:4H4L" /db_xref="SubtiList:BG10666" /db_xref="UniProtKB/Swiss-Prot:P10943" /translation="MTLHKERRIGRLSVLLLLNEAEESTQVEELERDGWKVCLGKVGS MDAHKVVAAIETASKKSGVIQSEGYRESHALYHATMEALHGVTRGEMLLGSLLRTVGL RFAVLRGNPYESEAEGDWIAVSLYGTIGAPIKGLEHETFGVGINHI*" /label="hutP CDS" gene 3490806..3491252 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /label="hutP gene" downshifts 3491257 /Source="Nicolas_upshifts" /id="D2042" /incds=0 /nref=157 /ntot=226 /MaxReadThrough="6.10706" /MaxDrop="5.43744" /score="3.19376411" /energy="-17.8" /TU="U3105" /idTUdmin="U3105" /TUdmin="-7018" /isTUend="FALSE" /label="downshifts" CDS 3491365..3492891 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /EC_number="4.3.1.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9535092, 10220322, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine ammonia-lyase (histidase)" /protein_id="NP_391814.1" /db_xref="EnsemblGenomes-Gn:BSU39350" /db_xref="EnsemblGenomes-Tr:CAB15971" /db_xref="GOA:P10944" /db_xref="InterPro:IPR001106" /db_xref="InterPro:IPR005921" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR022313" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10667" /db_xref="UniProtKB/Swiss-Prot:P10944" /translation="MVTLDGSSLTTADVARVLFDFEEAAASEESMERVKKSRAAVERI VRDEKTIYGINTGFGKFSDVLIQKEDSAALQLNLILSHACGVGDPFPECVSRAMLLLR ANALLKGFSGVRAELIEQLLAFLNKRVHPVIPQQGSLGASGDLAPLSHLALALIGQGE VFFEGERMPAMTGLKKAGIQPVTLTSKEGLALINGTQAMTAMGVVAYIEAEKLAYQTE RIASLTIEGLQGIIDAFDEDIHLARGYQEQIDVAERIRFYLSDSGLTTSQGELRVQDA YSLRCIPQVHGATWQTLGYVKEKLEIEMNAATDNPLIFNDGDKVISGGNFHGQPIAFA MDFLKIAISELANIAERRIERLVNPQLNDLPPFLSPHPGLQSGAMIMQYAAASLVSEN KTLAHPASVDSIPSSANQEDHVSMGTIAARHAYQVIANTRRVIAIEAICALQAVEYRG IEHAASYTKQLFQEMRKVVPSIQQDRVFSYDIERLTDWLKKESLIPDHQNKELRGMNI *" /label="hutH CDS" gene 3491365..3492891 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /label="hutH gene" CDS 3492888..3494546 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /EC_number="4.2.1.49" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15313616, 17395359, 22933560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urocanase" /protein_id="NP_391815.1" /db_xref="EnsemblGenomes-Gn:BSU39360" /db_xref="EnsemblGenomes-Tr:CAB15972" /db_xref="GOA:P25503" /db_xref="InterPro:IPR023636" /db_xref="InterPro:IPR023637" /db_xref="InterPro:IPR035085" /db_xref="InterPro:IPR035400" /db_xref="InterPro:IPR035401" /db_xref="InterPro:IPR036190" /db_xref="PDB:2FKN" /db_xref="SubtiList:BG10668" /db_xref="UniProtKB/Swiss-Prot:P25503" /translation="MTDVKKSIRANRGTELECLGWEQEAVLRMLRNNLDPEVAEKPED LIVYGGIGKAARDWDAFHAIEHSLKTLKNDETLLVQSGKPVGMFRTHPQAPRVLLANS VLVPKWADWEHFHELEKKGLMMYGQMTAGSWIYIGSQGILQGTYETFAELARQHFGGS LKGTLTLTAGLGGMGGAQPLSVTMNEGVVIAVEVDEKRIDKRIETKYCDRKTASIEEA LAWAEEAKLAGKPLSIALLGNAAEVHHTLLNRGVKIDIVTDQTSAHDPLIGYVPEGYS LDEADRLRQDTPELYVRLAKQSMKKHVEAMLAFQQKGSIVFDYGNNIRQVAKDEGLEN AFDFPGFVPAYIRPLFCEGKGPFRWAALSGDPADIYRTDALLKELFPTNKALHRWIDM AQEKVTFQGLPSRICWLGYGERKKMGLAINELVRTGELKAPVVIGRDHLDCGSVASPN RETEAMKDGSDAVGDWAVLNALVNTAAGASWVSFHHGGGVGMGYSLHAGMVAVADGSE LADERLARVLTSDPGMGIIRHADAGYERAVEVAKEQDIIVPMQK*" /label="hutU CDS" gene 3492888..3494546 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /label="hutU gene" CDS 3494559..3495824 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /EC_number="3.5.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16990261, 17395359, 18296777" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16990261, 17395359, 18296777; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazolone-5-propionate hydrolase" /protein_id="NP_391816.1" /db_xref="EnsemblGenomes-Gn:BSU39370" /db_xref="EnsemblGenomes-Tr:CAB15973" /db_xref="GOA:P42084" /db_xref="InterPro:IPR005920" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2BB0" /db_xref="PDB:2G3F" /db_xref="SubtiList:BG11100" /db_xref="UniProtKB/Swiss-Prot:P42084" /translation="MPKQIDTILINIGQLLTMESSGPRAGKSMQDLHVIEDAVVGIHE QKIVFAGQKGAEAGYEADEIIDCSGRLVTPGLVDPHTHLVFGGSREKEMNLKLQGISY LDILAQGGGILSTVKDTRAASEEELLQKAHFHLQRMLSYGTTTAEVKSGYGLEKETEL KQLRVAKKLHESQPVDLVSTFMGAHAIPPEYQNDPDDFLDQMLSLLPEIKEQELASFA DIFTETGVFTVSQSRRYLQKAAEAGFGLKIHADEIDPLGGAELAGKLKAVSADHLVGT SDEGIKKLAEAGTIAVLLPGTTFYLGKSTYARARAMIDEGVCVSLATDFNPGSSPTEN IQLIMSIAALHLKMTAEEIWHAVTVNAAYAIGKGEEAGQLKAGRSADLVIWQAPNYMY IPYHYGVNHVHQVMKNGTIVVNREGAILG*" /label="hutI CDS" gene 3494559..3495824 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /label="hutI gene" CDS 3495817..3496776 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /EC_number="3.5.3.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931887, 15355972, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formiminoglutamate hydrolase" /protein_id="NP_391817.1" /db_xref="EnsemblGenomes-Gn:BSU39380" /db_xref="EnsemblGenomes-Tr:CAB15974" /db_xref="GOA:P42068" /db_xref="InterPro:IPR005923" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="PDB:3M1R" /db_xref="SubtiList:BG11099" /db_xref="UniProtKB/Swiss-Prot:P42068" /translation="MDKYPFLREAGSSFKDRDVTKMSDLIATWDGQDIKGPALIGVPL SKSSISHSGASFAPGTIRQALKHSSAYSAELGEHVVSELLYDLGDIDIHVTDIVKSHH HIFQTMHALLSDHPDWVPLILGGDNSISYSTIKAIAQTKGTTAVIQFDAHHDVRNTED GGPTNGTPFRRLLDEEIIEGQHLIQLGIREFSNSQAYEAYAKKHNVNIHTMDMIREKG LIPTIKEILPVVQDKTDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIAQ QPNVAGIEIVEVDPTLDFRDMTSRAAAHVLLHALKGMKLSPFK*" /label="hutG CDS" gene 3495817..3496776 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /label="hutG gene" S_feature 3496777..3496851 /Source="Nicolas_S_feature" /locus_tag="new_4047463_4047537" /HighExp="Sw, BC, T3.30H, T4.0H, T5.0H, T3.0H, T2.30H, S8, M9-stat, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1517" CDS 3496852..3498279 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="histidine degradation metabolites permease" /protein_id="NP_391818.2" /db_xref="EnsemblGenomes-Gn:BSU39390" /db_xref="EnsemblGenomes-Tr:CAB15975" /db_xref="GOA:P42087" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11101" /db_xref="UniProtKB/Swiss-Prot:P42087" /translation="MNLQENSSQQLKRTMKSRHLFMISLGGVIGTGLFLSTGYTLHQA GPGGTILAYVIGGLMMYLVMQCLGELSVAMPVTGSFQKYATTFIGPSTGFMVGIMYWI NWVVTVGSEFTASGILMQRWFPDSSVWMWSAIFAALLFICNAFSVKLFAETEFWFSSV KIVTIILFIILGGAAMFGLISLNGTADAPMLSNFTDHGGLFPNGFLAVFIAMISVSFA FSGTELIGVTAGESANPQKDIPRSIRNVAWRTVIFFIGAVFILSGLISWKDAGVIESP FVAVFAEIGIPYAADIMNFVILTALLSVANSGLYASTRMMWSLANENMISSRFKKVTS KGIPLNALMISMAVSCLSLVSSIVAPGTVYVVMVAIAGFAGVVVWMSIALSQLLFRKR FLKKGGDVKDLTFRTPLYPLMPIAALLLCSASCIGLAFDPNQRIALFCGVPCIILCYL IYHFKRNVTKAKKISQEEYPADHIL*" /label="hutM CDS" gene 3496852..3498279 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /label="hutM gene" downshifts 3498275 /Source="Nicolas_upshifts" /id="D2043" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="0.7432" /MaxDrop="6.18816" /score="8.21347356" /energy="-11.7" /TU="NA" /idTUdmin="U3105" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3498323..3499624) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /EC_number="2.4.2.2" /EC_number="2.4.2.3" /EC_number="2.4.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 15530033, 16469506, 21707079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 15530033, 16469506, 21707079; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside phosphorylase" /protein_id="NP_391819.2" /db_xref="EnsemblGenomes-Gn:BSU39400" /db_xref="EnsemblGenomes-Tr:CAB15976" /db_xref="GOA:P39142" /db_xref="InterPro:IPR000053" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR013102" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR017872" /db_xref="InterPro:IPR018090" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="InterPro:IPR036566" /db_xref="PDB:5EP8" /db_xref="SubtiList:BG10985" /db_xref="UniProtKB/Swiss-Prot:P39142" /translation="MRMVDIIIKKQNGKELTTEEIQFFVNGYTDGSIPDYQASALAMA IFFQDMSDRERADLTMAMVNSGETIDLSAIEGIKVDKHSTGGVGDTTTLVLAPLVAAL DVPVAKMSGRGLGHTGGTIDKLEAIMGFHVELTKDEFIKLVNRDKVAVIGQSGNLTPA DKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAAELA KAMVRIGNNVGRQTMAVISDMSQPLGFAIGNALEVKEAIDTLKGEGPEDLHELVLTLG SQMVVLAKKADTLDEARAKLEEVMKNGKALEKFKDFLKNQGGDSSIVDDPSKLPQAAY QIDVPAKEAGVVSEIVADEIGVAAMLLGAGRATKEDEIDLAVGIMLRKKVGDKVEKGE PLVTLYANRENVDEVIAKVYDNIRIAAEAKAPKLIHTLITE*" /label="pdp CDS" gene complement(3498323..3499624) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /label="pdp gene" downshifts complement(3498340) /Source="Nicolas_upshifts" /id="D2044" /incds=0 /nref=122 /ntot=224 /MaxReadThrough="1.27022" /MaxDrop="5.60021" /score="14.0361257" /energy="-13.1" /TU="NA" /idTUdmin="U3107" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(3499654..3500835) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8550462, 11065368, 12591866, 15849754, 16850406, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 11065368, 12591866, 15849754, 16850406, 25890046; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside Na+(H+) cotransporter" /protein_id="NP_391820.2" /db_xref="EnsemblGenomes-Gn:BSU39410" /db_xref="EnsemblGenomes-Tr:CAB15977" /db_xref="GOA:P39141" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG10984" /db_xref="UniProtKB/Swiss-Prot:P39141" /translation="MKYLIGIIGLIVFLGLAWIASSGKKRIKIRPIVVMLILQFILGY ILLNTGIGNFLVGGFAKGFGYLLEYAAEGINFVFGGLVNADQTTFFMNVLLPIVFISA LIGILQKWKVLPFIIRYIGLALSKVNGMGRLESYNAVASAILGQSEVFISLKKELGLL NQQRLYTLCASAMSTVSMSIVGAYMTMLKPEYVVTALVLNLFGGFIIASIINPYEVAK EEDMLRVEEEEKQSFFEVLGEYILDGFKVAVVVAAMLIGFVAIIALINGIFNAVFGIS FQGILGYVFAPFAFLVGIPWNEAVNAGSIMATKMVSNEFVAMTSLTQNGFHFSGRTTA IVSVFLVSFANFSSIGIIAGAVKGLNEKQGNVVARFGLKLLYGATLVSFLSAAIVGLI Y*" /label="nupC CDS" gene complement(3499654..3500835) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /label="nupC gene" S_feature complement(3500836..3500915) /Source="Nicolas_S_feature" /locus_tag="new_4051522_4051601_c" /HighExp="G150, G135, Oxctl, G180, Mt0, M40t45, Lbtran, M0t90, M40t90, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1518" CDS complement(3500916..3501587) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /EC_number="4.1.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 27033207" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 27033207; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyribose-phosphate aldolase" /protein_id="NP_391821.2" /db_xref="EnsemblGenomes-Gn:BSU39420" /db_xref="EnsemblGenomes-Tr:CAB15978" /db_xref="GOA:P39121" /db_xref="InterPro:IPR002915" /db_xref="InterPro:IPR011343" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR028581" /db_xref="SubtiList:BG10983" /db_xref="UniProtKB/Swiss-Prot:P39121" /translation="MSLANIIDHTALKPHTQKADILKLIEEAKTYKFASVCVNPTWVE LAAKELKGTGVDVCTVIGFPLGANTTETKAFETKDAISKGATEVDMVINIAALKDKED DVVEADIRGVVEAVAGKALVKVIIETCLLTDEEKERACRLAVSAGADFVKTSTGFSTG GATKEDIALMRKTVGPDIGVKASGGVRTKEDVDTMVEAGASRIGASAGVSIVKGENAS GGDNY*" /label="deoC CDS" gene complement(3500916..3501587) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /label="deoC gene" promotor_-35 3501536..3501539 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3501554 /Source="Nicolas_upshifts" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3501555..3501574 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3501615..3501634) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3501630) /Source="Nicolas_upshifts" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3501648..3501655) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3501693..3502634) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 10714997, 24863636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 10714997, 24863636; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of pyrmidine deoxyribonucleosides degradation (DeoR-dR5P)" /protein_id="NP_391822.1" /db_xref="EnsemblGenomes-Gn:BSU39430" /db_xref="EnsemblGenomes-Tr:CAB15979" /db_xref="GOA:P39140" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR013324" /db_xref="PDB:4OQP" /db_xref="PDB:4OQQ" /db_xref="SubtiList:BG10982" /db_xref="UniProtKB/Swiss-Prot:P39140" /translation="MDREKQQLSIEAARLYYQSDYSQQQIAEQLNISRPTVSRLLQYA KEKGYVQIRVMDPFEDLDALGSILEEKYGLLEAHVVFSPTPDYAGITHDLSRYGAEYM HETVKDGDIVGVSWGTTMYQIAQNMQPKQVKGVEVVQLKGGISHSRVNTYSAETIQLF AEAFQTMPRYLPLPVVFDNADVKRMVEKDRHIERIIEMGKQANIALFTVGTVRDEALL FRLGYFNEEEKALLKKQAVGDICSRFFDAKGNICSSAINDRTIGVELQDLRLKERSIL VAGGSRKVSSIHGALTGKYANVLIIDQHTARALVNDL*" /label="deoR CDS" gene complement(3501693..3502634) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /label="deoR gene" promotor_-10 complement(3502679..3502698) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3502685) /Source="Nicolas_upshifts" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3502687..3502767) /Source="Nicolas_S_feature" /locus_tag="new_4053373_4053453_c" /HighExp="Etha, Diami, Salt, MG 10, Gly, MG 60, G180, GM 60, G135, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.55204399999999998" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1519" promotor_-35 complement(3502714..3502717) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3502768..3503595) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391823.2" /db_xref="EnsemblGenomes-Gn:BSU39440" /db_xref="EnsemblGenomes-Tr:CAB15980" /db_xref="GOA:P39139" /db_xref="InterPro:IPR009597" /db_xref="SubtiList:BG10981" /db_xref="UniProtKB/Swiss-Prot:P39139" /translation="MAVKDRYMSKIKQETKPWIKRFGRLGYFAFGGVFILLGVLAFMT AAGAGRAKDSSGALQTLSRMPYGSLLLFFIGIGLIGYVIWMVLSAIKDTEGHGNSRRG LSRRIGNFFSAAVYTSIAWNALRFVFGQGDGGTSEQTWSAYVLAQPFGQWLTGLTGAG FIVFAIVQFMKGVRAAFMKEFDTSKMNKQMICITKNTGRAGNIARAIIFSAIGYFLIK TAMTADPDDTRGFDGALAELAQQPHGKLILSILALGLILYGMYAIMKGIYQHMTWEK* " /label="yxxB CDS" gene complement(3502768..3503595) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" /label="yxxB gene" downshifts complement(3503567) /Source="Nicolas_upshifts" /id="D2045" /incds=0 /nref=6 /ntot=96 /MaxReadThrough="4.46865" /MaxDrop="3.48502" /score="14.6805498" /energy="-16" /TU="U3109,U3111" /idTUdmin="U3111" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3503620..3503638) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3503633) /Source="Nicolas_upshifts" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3503652..3503658) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3503668..3504780) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1860825, 10746760, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ethanolamine permease" /protein_id="NP_391824.1" /db_xref="EnsemblGenomes-Gn:BSU39450" /db_xref="EnsemblGenomes-Tr:CAB15981" /db_xref="GOA:P54957" /db_xref="InterPro:IPR007441" /db_xref="SubtiList:BG11894" /db_xref="UniProtKB/Swiss-Prot:P54957" /translation="MTVNDAVVFILAAFLLWGAADYCLGNRWGLGERFADGFKAMGPL ALSMIGIVSLAPVLAAILIPIVAPFYTAIGADPSSFANTILAIDMGGYALAGEMAKDP QAGLFSWVFLGTMMGPAIVFTIPVALGIIEKEDHPYFAKGILIGLCTVPIGCLIGGLC AGFDIGMIGKNLLIPSLLSAVIAFGLWRYTDRMIQLFHLFGKAVSMVAIIGLAAVSVE TMTGIVLIPGMENVETGIQTTGTIAIALAGAFPMTAFITKTFKKPLQALGKCLHLDET ATAGLVTSLAHHIPMLASLKDMTPRGKVINVAFAVSGAFVLGSHLGFVAGMKKEMAAA MIIGKLAGGVTAAAAAAWMTPAQSAKQQKRISASHS*" /label="yxeR CDS" gene complement(3503668..3504780) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" /label="yxeR gene" CDS complement(3504850..3506187) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative catabolic enzyme" /protein_id="NP_391825.2" /db_xref="EnsemblGenomes-Gn:BSU39460" /db_xref="EnsemblGenomes-Tr:CAB15982" /db_xref="GOA:P54956" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11893" /db_xref="UniProtKB/Swiss-Prot:P54956" /translation="MSKQGLTAGLAEAVRTSQPEHSVDAIHEAKKGLLDFTAASFAGR EDKGIQKLLRLIEDEGGRPLVPVIGQGKKAAPLQSAMLNGFIAHALDFDDVHSDVRGH PSAVIVPALIASAARGHDERLLGAYVVGVEVMARLGESIGSRHYEKGWHNTGTLGAIA AACAVGYAEELTQEELEKAIGFAATQSAGMRVQFGTEMKPLHAGLAAQAGLLAVKLAQ SEFGGSRTALDGETGFFSLYGDVEKAQHTLLNDWGAPWRIVQPGLWFKIYPFCSAAHH AADAVRQLISEETISAANTERIEVIFPPGGDAALTERSPKAGEEGRFSVEYVIALALH GHGLTVEHFSSQPIPNGVQTTMGRIQRVYDNAIQPAPHAVPKGRFTIVRAYLSDGRIC EARVDCPKGAPGNELSEEDIIEKLTLTVPQEKARRIITAVEKADIKEFLAHIE*" /label="yxeQ CDS" gene complement(3504850..3506187) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" /label="yxeQ gene" CDS complement(3506184..3507326) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-sulfur-metabolite deacetylase" /protein_id="NP_391826.2" /db_xref="EnsemblGenomes-Gn:BSU39470" /db_xref="EnsemblGenomes-Tr:CAB15983" /db_xref="GOA:P54955" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="PDB:1YSJ" /db_xref="SubtiList:BG11892" /db_xref="UniProtKB/Swiss-Prot:P54955" /translation="MADKAFHTRLINMRRDLHEHPELSFQEVETTKKIRRWLEEEQIE ILDVPQLKTGVIAEIKGREDGPVIAIRADIDALPIQEQTNLPFASKVDGTMHACGHDF HTASIIGTAMLLNQRRAELKGTVRFIFQPAEEIAAGARKVLEAGVLNGVSAIFGMHNK PDLPVGTIGVKEGPLMASVDRFEIVIKGKGGHAGIPNNSIDPIAAAGQIISGLQSVVS RNISSLQNAVVSITRVQAGTSWNVIPDQAEMEGTVRTFQKEARQAVPEHMRRVAEGIA AGYGAQAEFKWFPYLPSVQNDGTFLNAASEAAARLGYQTVHAEQSPGGEDFALYQEKI PGFFVWMGTNGTEEWHHPAFTLDEEALTVASQYFAELAVIVLETIK*" /label="sndB CDS" gene complement(3506184..3507326) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" /label="sndB gene" CDS complement(3507343..3508092) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391827.1" /db_xref="EnsemblGenomes-Gn:BSU39480" /db_xref="EnsemblGenomes-Tr:CAB15984" /db_xref="GOA:P54954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11891" /db_xref="UniProtKB/Swiss-Prot:P54954" /translation="MITVKNIRKAFKDLVVLDGIDLEVKRGEVVAIIGPSGSGKSTLL RCLNLLERPDQGLIEIGEAKLNAEKFTRKEAHRLRQQTAMVFQNYNLFKNKTALQNIT EALIVAQHKPRDEAKRIGMEILKQVGLEHKADSYPITMSGGQQQRIGIARALAVNPHA ILLDEPTSALDPELVTGVLQVIKSIAEKQTTMIIVTHEMAFAKEVADQVIFMADGHII EQGTPEELFDHPKNERTKRFIKQVGEPAELI*" /label="yxeO CDS" gene complement(3507343..3508092) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" /label="yxeO gene" CDS complement(3508105..3508779) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 15849754, 16513748, 16850406, 16885442; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391828.1" /db_xref="EnsemblGenomes-Gn:BSU39490" /db_xref="EnsemblGenomes-Tr:CAB15985" /db_xref="GOA:P54953" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11890" /db_xref="UniProtKB/Swiss-Prot:P54953" /translation="MNTIDWEFMISAFPTLIQALPITLFMAIAAMIFAIIGGLILALI TKNKIPVLHQLSKLYISFFRGVPTLVQLFLIYYGLPQLFPEMSKMTALTAAIIGLSLK NAAYLAEIFRAALNSVDDGQLEACLSVGMTKFQAYRRIILPQAIRNAIPATGNTFIGL LKETSLAFTLGVMEMFAQGKMYASGNLKYFETYLAVAIVYWVLTIIYSILQDLFERAM SKPYRT*" /label="yxeN CDS" gene complement(3508105..3508779) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" /label="yxeN gene" CDS complement(3508802..3509596) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_391829.1" /db_xref="EnsemblGenomes-Gn:BSU39500" /db_xref="EnsemblGenomes-Tr:CAB15986" /db_xref="GOA:P54952" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11889" /db_xref="UniProtKB/Swiss-Prot:P54952" /translation="MKMKKWTVLVVAALLAVLSACGNGNSSSKEDDNVLHVGATGQSY PFAYKENGKLTGFDVEVMEAVAKKIDMKLDWKLLEFSGLMGELQTGKLDTISNQVAVT DERKETYNFTKPYAYAGTQIVVKKDNTDIKSVDDLKGKTVAAVLGSNHAKNLESKDPD KKINIKTYETQEGTLKDVAYGRVDAYVNSRTVLIAQIKKTGLPLKLAGDPIVYEQVAF PFAKDDAHDKLRKKVNKALDELRKDGTLKKLSEKYFNEDITVEQKH*" /label="yxeM CDS" gene complement(3508802..3509596) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" /label="yxeM gene" promotor_-35 3509168..3509177 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3509189 /Source="Nicolas_upshifts" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3509190..3509205 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3509621..3510118) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur-containing aminoacid acetyltransferase" /protein_id="NP_391830.2" /db_xref="EnsemblGenomes-Gn:BSU39510" /db_xref="EnsemblGenomes-Tr:CAB15987" /db_xref="GOA:P54951" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11888" /db_xref="UniProtKB/Swiss-Prot:P54951" /translation="MKPRYRLAVERDAEQLLELTLRAYEPIRKLGIRFAAAHADLDLV LKNIRENACYVMEEDGRIIATITLRMPWGKQPGPYGVPHIWWFAVDPDTGKKGIGTKL LQWLEETILRDTLKVPFVSLGTADKHPWLIEMYERKGYVRSGEQDLGKGHITVYMKKQ LRHDL*" /label="snaB CDS" gene complement(3509621..3510118) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" /label="snaB gene" CDS complement(3510132..3511457) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8892809, 12193636, 15294834, 16513748, 16885442, 23944997; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391831.1" /db_xref="EnsemblGenomes-Gn:BSU39520" /db_xref="EnsemblGenomes-Tr:CAB15988" /db_xref="GOA:P54950" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG11887" /db_xref="UniProtKB/Swiss-Prot:P54950" /translation="MTSKKKQIKLGVFLAGTGHHVASWRHPDAPSDASMNLDYFKELA KTAERGKLDMLFLADSLSIDSKSHPNVLTRFEPFTLLSALAQVTSKIGLTATASTTYS EPFHIARQFASLDHLSNGRAGWNVVTSSIESTALNFSGEKHLEHHLRYQRAEEFVEIV KGLWDSWEEDAFIRNKETGEFFDKEKMHELNHKGEYFSVRGPLNVSRTPQGQPVIIQA GSSGDGKALAAKTAEVIFTAQNHLESAQEFYQSIKEQAAEFGRDPEKIAIMPGIFPII ADTEEAAQAKYKELQDLIIPSVGLQILQNYLGGIDLSAYPLDGPLPKLDAEASNAVKS RFKLVQEMAERDNMTIRELYKYVAGSRGHHIFVGTPEQLADKMQEWVDTKACDGFNIM PPLLPEGIEVFVDQVVPILQERGVFRKEYEGTTLREHFGLEKPVNRYAK*" /label="yxeK CDS" gene complement(3510132..3511457) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" /label="yxeK gene" promotor_-10 complement(3511534..3511553) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3511538) /Source="Nicolas_upshifts" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3511567..3511574) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3511643..3511870) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_391832.2" /db_xref="EnsemblGenomes-Gn:BSU39530" /db_xref="EnsemblGenomes-Tr:CAB15989" /db_xref="SubtiList:BG11886" /db_xref="UniProtKB/Swiss-Prot:P54949" /translation="MSLINSHQSADSGLNIWSQLFFYTIVTASEWIGGLQKRRKGKGN GEILYEIIGRKLSLCFIRLSFLADIEVALVE*" /label="yxeJ CDS" gene complement(3511643..3511870) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" /label="yxeJ gene" CDS complement(3511857..3512843) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" /EC_number="3.5.1.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15937167, 16511127, 18667582, 21978958" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937167, 16511127, 18667582, 21978958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin V amidase" /protein_id="NP_391833.2" /db_xref="EnsemblGenomes-Gn:BSU39540" /db_xref="EnsemblGenomes-Tr:CAB15990" /db_xref="GOA:P54948" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029132" /db_xref="PDB:2OQC" /db_xref="SubtiList:BG11885" /db_xref="UniProtKB/Swiss-Prot:P54948" /translation="MCTSLTLETADRKHVLARTMDFAFQLGTEVILYPRRYSWNSEAD GRAHQTQYAFIGMGRKLGNILFADGINESGLSCAALYFPGYAEYEKTIREDTVHIVPH EFVTWVLSVCQSLEDVKEKIRSLTIVEKKLDLLDTVLPLHWILSDRTGRNLTIEPRAD GLKVYDNQPGVMTNSPDFIWHVTNLQQYTGIRPKQLESKEMGGLALSAFGQGLGTVGL PGDYTPPSRFVRAVYLKEHLEPAADETKGVTAAFQILANMTIPKGAVITEEDEIHYTQ YTSVMCNETGNYYFHHYDNRQIQKVNLFHEDLDCLEPKVFSAKAEESIHELN*" /label="yxeI CDS" gene complement(3511857..3512843) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" /label="yxeI gene" downshifts complement(3511861) /Source="Nicolas_upshifts" /id="D2046" /incds=0 /nref=7 /ntot=52 /MaxReadThrough="2.95669" /MaxDrop="3.32309" /score="23.0334771" /energy="-17.9" /TU="NA" /idTUdmin="U3113" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3511994..3512003 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3512017..3512036 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3512027..3512660 /Source="Nicolas_S_feature" /locus_tag="new_4062713_4063346" /HighExp="S6, S7, S8, S5, Paraq, G150, H2O2, G180, LBGexp, Oxctl" /AntisenseName="yxeI" /AntisenseCor="0.24221971906572701" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S1520" upshifts 3512027 /Source="Nicolas_upshifts" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3512898..3512917) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3512909) /Source="Nicolas_upshifts" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3512932..3512939) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3512998..3513810) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 21575135, 23582330, 25527541, 25848029, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sugar-phosphate hydrolase (promiscuous)" /protein_id="NP_391834.1" /db_xref="EnsemblGenomes-Gn:BSU39550" /db_xref="EnsemblGenomes-Tr:CAB15991" /db_xref="GOA:P54947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11884" /db_xref="UniProtKB/Swiss-Prot:P54947" /translation="MYKLIAIDMDGTLLNDHHEVTEEVRDALHAAKAEGVKIVLCTGR PIGGVQRYLDELNLIEEGDYVIAYNGALVQNTHTNEVVSELSLGYDDLTSLYDLSLEL KTPMHFFDSSNLYTPNRDISEFTVYESYVTQVPLHFRKIDEVPKDILIPKVMFIDKPE NLSRVITSIPKDVREKYTMVRSAPFFYEILHSEASKGNAVRQLAQLLGIEQAEVMCIG DNGNDLTMIEWAGCGVAMANAIPEVLEAANFQTRSNNEHGVAHAIHELVLAK*" /label="hadM CDS" gene complement(3512998..3513810) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" /label="hadM gene" promotor_-10 complement(3513840..3513859) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3513850..3514407) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391835.1" /db_xref="EnsemblGenomes-Gn:BSU39560" /db_xref="EnsemblGenomes-Tr:CAB15992" /db_xref="GOA:P54946" /db_xref="SubtiList:BG11883" /db_xref="UniProtKB/Swiss-Prot:P54946" /translation="MRNQKAERLVAAGLVLHIIQWIFILWAFLKVKHLFSDYTIYNPN VISGSMQSLSFIQMMRAMMYSGAIVNYVLFFALVLLIYGIVLHAILIVLEMAAYVMIR RNPSSSWGFFFIAAGVKLAILNITGIPFLAAGFLLMKQKKAENGVKAERKRKPRLRIR RQGRRLNRIRRKPSLPVEYQKEKTI*" /label="yxeG CDS" gene complement(3513850..3514407) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" /label="yxeG gene" upshifts complement(3513863) /Source="Nicolas_upshifts" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3513874..3513881) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3514388..3514822) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" /function="18: Unknown function" /experiment="publication(s) with functional evidences, PMID:11160890, 22693626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 22693626; Product type s: structure" /codon_start=1 /transl_table=11 /product="lipocalin-like lipoprotein" /protein_id="NP_391836.1" /db_xref="EnsemblGenomes-Gn:BSU39570" /db_xref="EnsemblGenomes-Tr:CAB15993" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR021664" /db_xref="PDB:2JOZ" /db_xref="SubtiList:BG11882" /db_xref="UniProtKB/Swiss-Prot:P54945" /translation="MVIPLRNKYGILFLIAVCIMVSGCQQQKEETPFYYGTWDEGRAP GPTDGVKSATVTFTEDEVVETEVMEGRGEVQLPFMAYKVISQSTDGSIEIQYLGPYYP LKSTLKRGENGTLIWEQNGQRKTMTRIESKTGREEKDEKSKS*" /label="yxeF CDS" gene complement(3514388..3514822) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" /label="yxeF gene" promotor_-35 3514847..3514856 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3514866 /Source="Nicolas_upshifts" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3514869..3514888 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3514882) /Source="Nicolas_upshifts" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3514883..3515294) /Source="Nicolas_S_feature" /locus_tag="new_4065569_4065980_c" /HighExp="Salt, H2O2, Paraq, dia15, Oxctl, Diami, Cold, G150, Lbtran, LBGexp" /AntisenseName="yxeE" /AntisenseCor="-0.602938477548701" /AntisenseRegPval="-27.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.391, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1521" promotor_-10 complement(3514888..3514902) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3514911..3514915) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3514911..3515276 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 17905812, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 17905812, 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391837.1" /db_xref="EnsemblGenomes-Gn:BSU39580" /db_xref="EnsemblGenomes-Tr:CAB15994" /db_xref="SubtiList:BG11881" /db_xref="UniProtKB/Swiss-Prot:P54944" /translation="MNPYQYYSPQLPQQEPYYSHYEYNPYPQQDVYDPYQMDRQPALE RRIAALERQNEQQSRELTRLTNEDRRQNREIARIAEQVNQLSQAVERHTRRLNRLNQR LRTVENRLNIPFTAGEGGF*" /label="cotNE CDS" gene 3514911..3515276 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" /label="cotNE gene" downshifts 3515290 /Source="Nicolas_upshifts" /id="D2047" /incds=0 /nref=31 /ntot=47 /MaxReadThrough="1.46494" /MaxDrop="8.36553" /score="27.2157513" /energy="-12.2" /TU="U3115" /idTUdmin="U3115" /TUdmin="-38" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3515294..3515298) /Source="Nicolas_upshift_promotors" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3515294) /Source="Nicolas_upshifts" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3515296..3515382) /Source="Nicolas_S_feature" /locus_tag="new_4065982_4066068_c" /HighExp="Salt, S8, H2O2, dia15, S7, Paraq, Diami, aero, Oxctl, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1522" promotor_-10 complement(3515375..3515394) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3515382) /Source="Nicolas_upshifts" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3515408..3515415) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3515455..3515461 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3515475..3515486 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3515482 /Source="Nicolas_upshifts" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="upshifts" CDS 3515524..3515877 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26506528" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391838.2" /db_xref="EnsemblGenomes-Gn:BSU39590" /db_xref="EnsemblGenomes-Tr:CAB15995" /db_xref="SubtiList:BG11880" /db_xref="UniProtKB/Swiss-Prot:P54943" /translation="MHNTQHGLQQLNQCRQTAQQLIQQTQQSSQQYRQMLHQEQQNIQ MLQQILNHEQQAAHTIQQALHGHDMAIQKCQQVVNMCNQMQQELTGQSSVMNTNVSTL PFGQNTTFQQQSYQQ*" /label="yxeD CDS" gene 3515524..3515877 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" /label="yxeD gene" downshifts 3515872 /Source="Nicolas_upshifts" /id="D2048" /incds=0 /nref=24 /ntot=55 /MaxReadThrough="0.20641" /MaxDrop="6.88486" /score="27.2157513" /energy="-12.2" /TU="NA" /idTUdmin="U3119" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(3515921..3516319) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391839.2" /db_xref="EnsemblGenomes-Gn:BSU39600" /db_xref="EnsemblGenomes-Tr:CAB15996" /db_xref="GOA:P54942" /db_xref="SubtiList:BG11879" /db_xref="UniProtKB/Swiss-Prot:P54942" /translation="MGITKRGAAWEWLHSWWMLFIFMPFAITSFFAFLFIGIKVRNRK WIMYGIIYFFIFAFGFVLPDLPGVFIVVPLWAVTIIHGFKVRPLYLIQLDVYKDHVEA RAFAEARSEAESRFHAPKQSIQDIHIRKEQ*" /label="yxeC CDS" gene complement(3515921..3516319) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" /label="yxeC gene" downshifts complement(3515929) /Source="Nicolas_upshifts" /id="D2049" /incds=0 /nref=145 /ntot=243 /MaxReadThrough="1.70512" /MaxDrop="5.26494" /score="9.81431167" /energy="-12.2" /TU="NA" /idTUdmin="U3120" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3516334..3516353) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3516350) /Source="Nicolas_upshifts" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3516368..3516371) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3516407..3516414 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3516423..3516441) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3516429..3516448 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3516438 /Source="Nicolas_upshifts" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3516438) /Source="Nicolas_upshifts" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3516457..3516462) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3516497..3517462 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 16672620, 8388528, 19254027, 23924612, 25007174; Product type t : transporter" /codon_start=1 /transl_table=11 /product="desferrioxamine-and ferrichrome-binding transporter lipoprotein (shuttle system)" /protein_id="NP_391840.2" /db_xref="EnsemblGenomes-Gn:BSU39610" /db_xref="EnsemblGenomes-Tr:CAB15997" /db_xref="GOA:P54941" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG11878" /db_xref="UniProtKB/Swiss-Prot:P54941" /translation="MKKNILLVGMLVLLLMFVSACSGTASKGSSSDSASEKTEMRTYK SPKGNVNIPAHPKRIVTDFYAGELLSVGANVVGSGSWSFDNPFLKSKLKNVKDVGDPI SVEKVMELQPDLIVVMNEENVDKLKKIAPTVVIPYNTAKNVEDTVSMFGDIAGAKDQA KSFMADFNKKAEAAKKKIAGVIDKDATFGIYENTDKGEFWVFNDNGGRGGQAVYNALG LKAPEKIEQDVIKKGEMKQLSQEVIPEYAADYMFITDYNPKGESKTLDKLENSSIWKN LDAVKHNRVFINDFDSFYPYDPISVSKQVDIITDMLIKRAEENKK*" /label="frxB CDS" gene 3516497..3517462 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" /label="frxB gene" upshifts 3516890 /Source="Nicolas_upshifts" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3516897..3516915 /Source="Nicolas_upshift_promotors" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3517369 /Source="Nicolas_upshifts" /id="D2050" /incds=1 /nref=55 /ntot=191 /MaxReadThrough="6.103" /MaxDrop="4.3334" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=193 /isTUend="FALSE" /label="downshifts" downshifts 3517440 /Source="Nicolas_upshifts" /id="D2051" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="4.41732" /MaxDrop="3.7101" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=264 /isTUend="FALSE" /label="downshifts" S_feature 3517485..3518281 /Source="Nicolas_S_feature" /locus_tag="new_4068171_4068967" /HighExp="H2O2, Paraq, Lbexp, dia0, LBGexp, G150, B36, dia15, B60, GM 25" /AntisenseName="yxeA" /AntisenseCor="0.20524492145617201" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1523" CDS complement(3517503..3517850) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391841.1" /db_xref="EnsemblGenomes-Gn:BSU39620" /db_xref="EnsemblGenomes-Tr:CAB15998" /db_xref="InterPro:IPR006542" /db_xref="InterPro:IPR036166" /db_xref="PDB:3NPP" /db_xref="SubtiList:BG11877" /db_xref="UniProtKB/Swiss-Prot:P54940" /translation="MKKAMAILAVLAAAAVICGLLFFHNDVTDRFNPFIHQQDVYVQI DRDGRHLSPGGTEYTLDGYNASGKKEEVTFFAGKELRKNAYLKVKAKGKYVETWEEVK FEDMPDSVQSKLK*" /label="yxeA CDS" gene complement(3517503..3517850) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" /label="yxeA gene" downshifts complement(3517516) /Source="Nicolas_upshifts" /id="D2052" /incds=0 /nref=2 /ntot=78 /MaxReadThrough="1.28842" /MaxDrop="2.99568" /score="38.5550476" /energy="-11.6" /TU="NA" /idTUdmin="U3120" /TUdmin="-1584" /isTUend="FALSE" /label="downshifts" CDS complement(3517864..3519732) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15849754, 15870467, 16850406, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15849754, 15870467, 16850406, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease); efflux of cationic peptides" /protein_id="NP_391842.2" /db_xref="EnsemblGenomes-Gn:BSU39630" /db_xref="EnsemblGenomes-Tr:CAB15999" /db_xref="GOA:P42424" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG11129" /db_xref="UniProtKB/Swiss-Prot:P42424" /translation="MTFLQFAYKNVTRNKRAYLAFFLSSAFSVLIFFTFAMFLFHPAL KEGYLNNIAKKGLTAAEWMIFVFSFLFVLYSVNAFLKSRNKEFGILLMQGITPGQLRK LITAENMIIGVMSIAAGIIGGFIFSKTFFTVGAYILEMDALPLYMPWKALGITACGFL LLFFFLSQFTILFVRSNTVIKLIKGTGKVKPEPKPSVLLSLFGIACLCGGYGMVLKGN VHGAEPFIILLLTVIGTYFFFSQSSIWILRALKKWKTFYLRGKNIIWVSDLVYRLKDN ARLFFIVSIISAVAFTATGVLAMYKSTVGAEESAYEMEYLSYSNNPKEQTHLKDIDHE LKTHGFTYTKDKIDVSYVRYQEGETVPPVYMISESDAAKYFHVKVNGLKEDEAVYFPG TYDRNFKNEAPDQLKLLNQKGELSDQKLSVKEVKKPLISLNAIIAVNDQTFDQLKSLG DKASLYGYSYDHWKDSLEISQSLQNEIYGNYIDVHSDFASKAGTYYDTVQLPSLSLFI GLFIAIVFFVAAASFLYFRLFTDLDEDRERYRSLAKIGLSEREMAQSVTIQLAILFFF PFVIAVMHTLFALRTLAVEGYSDVAGPLSLTIGGFFIFQLLFFLAVRSSYLKKMNK*" /label="tpeM CDS" gene complement(3517864..3519732) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" /label="tpeM gene" CDS complement(3519707..3520480) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15870467, 17600057, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15870467, 17600057, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein); efflux ofcationic peptides" /protein_id="NP_391843.2" /db_xref="EnsemblGenomes-Gn:BSU39640" /db_xref="EnsemblGenomes-Tr:CAB16000" /db_xref="GOA:P42423" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11128" /db_xref="UniProtKB/Swiss-Prot:P42423" /translation="MANMLEVKHINKTYKGQVSYQALKQISFSIEEGEFTAVMGPSGS GKTTLLNIISTIDRPDSGDILINGENPHRLKRTKLAHFRRKQLGFVFQDFNLLDTLTI GENIMLPLTLEKEAPSVMEEKLHGIAAKLGIENLLNKRTFEVSGGQRQRAAIARAVIH KPSLILADEPTGNLDSKATKDVMETLQSLNRDDHVTALMVTHDPVSASYCRRVIFIKD GELFNEIYRGENRQVFYEQILDVLSMLGGNANDLSSVRL*" /label="tpeL CDS" gene complement(3519707..3520480) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" /label="tpeL gene" CDS complement(3520624..3521601) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxdJ]" /protein_id="NP_391844.1" /db_xref="EnsemblGenomes-Gn:BSU39650" /db_xref="EnsemblGenomes-Tr:CAB16001" /db_xref="GOA:P42422" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11127" /db_xref="UniProtKB/Swiss-Prot:P42422" /translation="MKLFLRSHAVLILLFLLQGLFVFFYYWFAGLHSFSHLFYILGVQ LLILAGYLAYRWYKDRGVYHWLSSGQEGTDIPYLGSSVFCSELYEKQMELIRLQHQKL HETEAKLDARVTYMNQWVHQVKTPLSVINLIIQEEDEPVFEQIKKEVRQIEFGLETLL YSSRLDLFERDFKIEAVSLSELLQSVIQSYKRFFIQYRVYPKMNVCDDHQIYTDAKWL KFAIGQVVTNAVKYSAGKSDRLELNVFCDEDRTVLEVKDYGVGIPSQDIKRVFDPYYT GENGRRFQESTGIGLHLVKEITDKLNHTVDISSSPGEGTSVRFSFLTKM*" /label="tpeK CDS" gene complement(3520624..3521601) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" /label="tpeK gene" CDS complement(3521598..3522287) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [TpeK(YxdK)]" /protein_id="NP_391845.1" /db_xref="EnsemblGenomes-Gn:BSU39660" /db_xref="EnsemblGenomes-Tr:CAB16002" /db_xref="GOA:P42421" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11126" /db_xref="UniProtKB/Swiss-Prot:P42421" /translation="MNKIMIVEDSEDIRGLLQNYLEKYGYQTVVAADFTAVLDVFLRE KPDVVLLDINLPAYDGYYWCRQIRQHSTSPIIFISARSGEMDQVMAIENGGDDYIEKP FSYDIVLAKIKSQIRRAYGEYAAKQGEKVVEYAGVQLFVERFELRFQDEKSELSKKES KLLEVLLERGEKVTSRDRLMEKTWDTDIFIDDNTLNVYITRLRKKLRELNAPVSIEAV RGEGYQLRAQS*" /label="tpeJ CDS" gene complement(3521598..3522287) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" /label="tpeJ gene" promotor_-10 complement(3522314..3522333) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3522332) /Source="Nicolas_upshifts" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3522348..3522354) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3522395..3523267) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" /EC_number="4.1.2.29" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 10658656, 11325924, 18310071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 10658656, 11325924, 18310071; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid 6-phosphate aldolase" /protein_id="NP_391846.1" /db_xref="EnsemblGenomes-Gn:BSU39670" /db_xref="EnsemblGenomes-Tr:CAB16003" /db_xref="GOA:P42420" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11125" /db_xref="UniProtKB/Swiss-Prot:P42420" /translation="MAFVSMKELLEDAKREQYAIGQFNINGLQWTKAILQAAQKEQSP VIAAASDRLVDYLGGFKTIAAMVGALIEDMAITVPVVLHLDHGSSAERCRQAIDAGFS SVMIDGSHQPIDENIAMTKEVTDYAAKHGVSVEAEVGTVGGMEDGLVGGVRYADITEC ERIVKETNIDALAAALGSVHGKYQGEPNLGFKEMEAISRMTDIPLVLHGASGIPQDQI KKAITLGHAKININTECMVAWTDETRRMFQENSDLYEPRGYLTPGIEAVEETVRSKMR EFGSAGKAAKQQVG*" /label="iolJ CDS" gene complement(3522395..3523267) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" /label="iolJ gene" downshifts complement(3522399) /Source="Nicolas_upshifts" /id="D2053" /incds=0 /nref=89 /ntot=172 /MaxReadThrough="3.05314" /MaxDrop="6.87265" /score="26.7325466" /energy="-8.2" /TU="NA" /idTUdmin="U3126" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3523288..3524124) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" /EC_number="5.3.99.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inosose isomerase" /protein_id="NP_391847.1" /db_xref="EnsemblGenomes-Gn:BSU39680" /db_xref="EnsemblGenomes-Tr:CAB16004" /db_xref="GOA:P42419" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="PDB:1I60" /db_xref="PDB:1I6N" /db_xref="SubtiList:BG11124" /db_xref="UniProtKB/Swiss-Prot:P42419" /translation="MKLCFNEATTLENSNLKLDLELCEKHGYDYIEIRTMDKLPEYLK DHSLDDLAEYFQTHHIKPLALNALVFFNNRDEKGHNEIITEFKGMMETCKTLGVKYVV AVPLVTEQKIVKEEIKKSSVDVLTELSDIAEPYGVKIALEFVGHPQCTVNTFEQAYEI VNTVNRDNVGLVLDSFHFHAMGSNIESLKQADGKKIFIYHIDDTEDFPIGFLTDEDRV WPGQGAIDLDAHLSALKEIGFSDVVSVELFRPEYYKLTAEEAIQTAKKTTVDVVSKYF SM*" /label="iolI CDS" gene complement(3523288..3524124) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" /label="iolI gene" S_feature complement(3524125..3524209) /Source="Nicolas_S_feature" /locus_tag="new_4074811_4074895_c" /HighExp="M40t90, M0t90, BI, Sw, BC, T5.0H, T0.30H, T4.0H, T3.30H, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.101524" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1524" CDS complement(3524210..3525079) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9887260, 11566986, 12112707, 23874669; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_391848.1" /db_xref="EnsemblGenomes-Gn:BSU39690" /db_xref="EnsemblGenomes-Tr:CAB16005" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11123" /db_xref="UniProtKB/Swiss-Prot:P42418" /translation="MKLALDPSMYRDDLTLEEMVYKTAELGYEYIELSPREDFCPFYK YPKVDSAKIKQLKRLLRDTGVKLSSLLPLYHWAGPDEDRRQAAVRNWKRAIEIAVELE VDLMNSEFSGSKYDPLTSEEKFIKSMDELLPVFEKEGIKLNLQAHPYDFIETHKGAMD MIRALDKDWINLVYSTAHTFFYDDGKGDIETMFDEAGDRLTHVLFADTYNHKAAHGLR YIVNPPDAKVTVHQHLDIGQGEVDFDTIFRKLREMKFDGIATNAVFAWVDERADESSR FMLKKMKEELGLA*" /label="iolH CDS" gene complement(3524210..3525079) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" /label="iolH gene" CDS complement(3525099..3526133) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" /EC_number="1.1.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase" /protein_id="NP_391849.2" /db_xref="EnsemblGenomes-Gn:BSU39700" /db_xref="EnsemblGenomes-Tr:CAB16006" /db_xref="GOA:P26935" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR023794" /db_xref="InterPro:IPR036291" /db_xref="PDB:3MZ0" /db_xref="PDB:3NT2" /db_xref="PDB:3NT4" /db_xref="PDB:3NT5" /db_xref="PDB:3NTO" /db_xref="PDB:3NTQ" /db_xref="PDB:3NTR" /db_xref="PDB:4L8V" /db_xref="PDB:4L9R" /db_xref="SubtiList:BG10669" /db_xref="UniProtKB/Swiss-Prot:P26935" /translation="MSLRIGVIGTGAIGKEHINRITNKLSGAEIVAVTDVNQEAAQKV VEQYQLNATVYPNDDSLLADENVDAVLVTSWGPAHESSVLKAIKAQKYVFCEKPLATT AEGCMRIVEEEIKVGKRLVQVGFMRRYDSGYVQLKEALDNHVIGEPLMIHCAHRNPTV GDNYTTDMAVVDTLVHEIDVLHWLVNDDYESVQVIYPKKSKNALPHLKDPQIVVIETK GGIVINAEIYVNCKYGYDIQCEIVGEDGIIKLPEPSSISLRKEGRFSTDILMDWQRRF VAAYDVEIQDFIDSIQKKGEVSGPTAWDGYIAAVTTDACVKAQESGQKEKVELKEKPE FYQSFTTVQN*" /label="iolG CDS" gene complement(3525099..3526133) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" /label="iolG gene" CDS complement(3526156..3527472) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="inositol transport protein" /protein_id="NP_391850.2" /db_xref="EnsemblGenomes-Gn:BSU39710" /db_xref="EnsemblGenomes-Tr:CAB16007" /db_xref="GOA:P42417" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11122" /db_xref="UniProtKB/Swiss-Prot:P42417" /translation="MGNTNGDSAFNKRTIAAALANYIDAGSIVAGSAGLSLWVSYLKL SDTQIGLLGALSANAISAAVGALLGGFLADKVGRKAVYTNSMLVYALGICLVLFGVNF PMLLSGYIIIGLSVGADITASWTIIAENAPKKNRARHCGVAQVAWAAGAVVVLLLSVL AGDLGLLGNKIVFAHLLVIALITYILRIRLPESDAWQTKNQPEEAQAEKPAVLNKTSY FDLLKPMYLKSILFLMGVYLVWNLAAGVMGFFMPYIYQQVGGVSANMANLLQMGLFIF TGLGVALIFMPFADKYRKTVFGIAAFMAVIGWTLFLLPVEGLPILLLFIVVIGINNGA GQQANYQLWASEIFPTQYRASAQGLMFFLVRISIGIWSLFVPMIITNFGIGTMAAILL GCVTASMIIGLLFAPNTSGKSLEQIQEELYGSPQSQVKKGTESKIM*" /label="iolF CDS" gene complement(3526156..3527472) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" /label="iolF gene" CDS complement(3527487..3528380) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" /EC_number="4.2.1.44" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 14993306, 22720735, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 14993306, 22720735, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inosose dehydratase" /protein_id="NP_391851.1" /db_xref="EnsemblGenomes-Gn:BSU39720" /db_xref="EnsemblGenomes-Tr:CAB16008" /db_xref="GOA:P42416" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR023952" /db_xref="InterPro:IPR030823" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11121" /db_xref="UniProtKB/Swiss-Prot:P42416" /translation="MGKNEILWGIAPIGWRNDDMPEIGAGNTLQHLLSDIVVARFQGT EVGGFFPEPAILNKELKLRNLRIAGKWFSSFILRDGLGEAAKTFTLHCEYLQQVNADV AVVSEQTYSVQSLEKNVFTEKPHFTDDEWERLCEGLNHLGEIAAQHGLKLVYHHHLGT GVQTAEEVDRLMAGTDPAHVHLLYDTGHAYISDGDYMGMLEKHIGRIKHVHFKDARLN VMEQCRLEGQSFRQSFLKGMFTVPGDGCIDFREVYQLLLKHSYSGWIVIEAEQDPDVA NPLEYALIARNYIDQQLLDLA*" /label="iolE CDS" gene complement(3527487..3528380) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" /label="iolE gene" CDS complement(3528397..3530310) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" /EC_number="3.7.1.22" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase" /protein_id="NP_391852.2" /db_xref="EnsemblGenomes-Gn:BSU39730" /db_xref="EnsemblGenomes-Tr:CAB16009" /db_xref="GOA:P42415" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR023757" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR030817" /db_xref="SubtiList:BG11120" /db_xref="UniProtKB/Swiss-Prot:P42415" /translation="MGKKIRLTTAQALIKFLNQQYIHVDGKEEPFVEGIFTIFGHGNV LGIGQALEQDAGHLKVYQGKNEQGMAHAAMAYSKQMLRRKIYAVSTSVGPGAANLVAA AGTALANNIPVLLIPADTFATRQPDPVLQQMEQEYSAAITTNDALKPVSRYWDRITRP EQLMSSLLRAFEVMTDPAKAGPATICISQDVEGEAYDFDESFFVKRVHYIDRMQPSER ELQGAAELIKSSKKPVILVGGGAKYSGARDELVAISEAYNIPLVETQAGKSTVEADFA NNLGGMGITGTLAANKAARQADLIIGIGTRYTDFATSSKTAFDFDKAKFLNINVSRMQ AYKLDAFQVVADAKVTLGKLHGLLEGYESEFGTTIRELKDEWLAERERLSKVTFKREA FDPEIKNHFSQEVLNEYADALNTELPQTTALLTINETIPEDSVIICSAGSLPGDLQRL WHSNVPNTYHLEYGYSCMGYEVSGTLGLKLAHPDREVYSIVGDGSFLMLHSELITAIQ YNKKINVLLFDNSGFGCINNLQMDHGSGSYYCEFRTDDNQILNVDYAKVAEGYGAKTY RANTVEELKAALEDAKKQDVSTLIEMKVLPKTMTDGYDSWWHVGVAEVSEQESVQKAY EAKEKKLESAKQY*" /label="iolD CDS" gene complement(3528397..3530310) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" /label="iolD gene" CDS complement(3530343..3531320) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" /EC_number="2.7.1.92" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid kinase" /protein_id="NP_391853.1" /db_xref="EnsemblGenomes-Gn:BSU39740" /db_xref="EnsemblGenomes-Tr:CAB16010" /db_xref="GOA:P42414" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR022841" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="InterPro:IPR030830" /db_xref="SubtiList:BG11119" /db_xref="UniProtKB/Swiss-Prot:P42414" /translation="MKYTFNEEKAFDIVAIGRACIDLNAVEYNRPMEETMTFSKYVGG SPANIAIGSAKLGLKAGFIGKIPDDQHGRFIESYMRKTGVDTTQMIVDQDGHKAGLAF TEILSPEECSILMYRDDVADLYLEPSEVSEDYIANAKMLLVSGTALAKSPSREAVLKA VQYAKKHQVKVVFELDYRPYTWQSSDETAVYYSLVAEQSDIVIGTRDEFDVMENRTGG SNEESVNHLFGHSADLVVIKHGVEGSYAYSKSGEVFRAQAYKTKVLKTFGAGDSYASA FIYGLVSGKDIETALKYGSASASIVVSKHSSSEAMPTAEEIEQLIEAQS*" /label="iolC CDS" gene complement(3530343..3531320) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" /label="iolC gene" CDS complement(3531344..3532159) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" /EC_number="5.3.1.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-deoxy-D-glucuronic acid isomerase" /protein_id="NP_391854.2" /db_xref="EnsemblGenomes-Gn:BSU39750" /db_xref="EnsemblGenomes-Tr:CAB16011" /db_xref="GOA:P42413" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR023770" /db_xref="InterPro:IPR024203" /db_xref="SubtiList:BG11118" /db_xref="UniProtKB/Swiss-Prot:P42413" /translation="MSYLLRKPQSHEVSNGVKLVHEVTTSNSDLTYVEFKVLDLASGS SYTEELKKQEICIVAVTGKITVTDHESTFENIGTRESVFERKPTDSVYISNDRAFEIT AVSDARVALCYSPSEKQLPTKLIKAEDNGIEHRGQFSNKRTVHNILPDSDPSANSLLV VEVYTDSGNWSSYPPHKHDQDNLPEESFLEETYYHELDPGQGFVFQRVYTDDRSIDET MTVGNENVVIVPAGYHPVGVPDGYTSYYLNVMAGPTRKWKFYNDPAHEWILER*" /label="iolB CDS" gene complement(3531344..3532159) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" /label="iolB gene" S_feature complement(3532160..3532233) /Source="Nicolas_S_feature" /locus_tag="new_4082846_4082919_c" /HighExp="M40t90, M0t90, Lbtran, BI, Mt0, T0.30H, Sw, BC, S1, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1525" CDS complement(3532234..3533697) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" /EC_number="1.2.1.27" /EC_number="1.2.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylmalonate-semialdehyde dehydrogenase" /protein_id="NP_391855.1" /db_xref="EnsemblGenomes-Gn:BSU39760" /db_xref="EnsemblGenomes-Tr:CAB16012" /db_xref="GOA:P42412" /db_xref="InterPro:IPR010061" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR023510" /db_xref="PDB:1T90" /db_xref="SubtiList:BG11117" /db_xref="UniProtKB/Swiss-Prot:P42412" /translation="MAEIRKLKNYINGEWVESKTDQYEDVVNPATKEVLCQVPISTKE DIDYAAQTAAEAFKTWSKVAVPRRARILFNFQQLLSQHKEELAHLITIENGKNTKEAL GEVGRGIENVEFAAGAPSLMMGDSLASIATDVEAANYRYPIGVVGGIAPFNFPMMVPC WMFPMAIALGNTFILKPSERTPLLTEKLVELFEKAGLPKGVFNVVYGAHDVVNGILEH PEIKAISFVGSKPVGEYVYKKGSENLKRVQSLTGAKNHTIVLNDANLEDTVTNIVGAA FGSAGERCMACAVVTVEEGIADEFMAKLQEKVADIKIGNGLDDGVFLGPVIREDNKKR TLSYIEKGLEEGARLVCDGRENVSDDGYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIR VKNLKEAIEIANKSEFANGACLFTSNSNAIRYFRENIDAGMLGINLGVPAPMAFFPFS GWKSSFFGTLHANGKDSVDFYTRKKVVTARYPAPDFN*" /label="iolA CDS" gene complement(3532234..3533697) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" /label="iolA gene" S_feature complement(3533698..3533902) /Source="Nicolas_S_feature" /locus_tag="new_4084384_4084588_c" /HighExp="M0t90, M40t90, Lbtran, BI, Mt0, T0.30H, BC, S1, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1526" promotor_-35 3533701..3533708 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-35" promotor_-10 3533724..3533743 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-10" upshifts 3533731 /Source="Nicolas_upshifts" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="upshifts" S_feature 3533738..3534044 /Source="Nicolas_S_feature" /locus_tag="new_4084424_4084730" /HighExp="G180, Paraq, G150, Oxctl, H2O2, G135, Diami, LBGexp, dia5, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.788" /TUlongSig="NA" /TUlongPSig="NA" /label="S1527" promotor_-10 complement(3533884..3533903) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3533902) /Source="Nicolas_upshifts" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3533904..3534056) /Source="Nicolas_S_feature" /locus_tag="new_4084590_4084742_c" /HighExp="M40t90, M0t90, Lbtran, Diami, Heat, dia5, C30, BI, S1, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1528" promotor_-35 complement(3533918..3533925) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3534004..3534011 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-35" promotor_-10 3534026..3534045 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-10" upshifts 3534046 /Source="Nicolas_upshifts" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="upshifts" promotor_-10 complement(3534057..3534076) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-10" upshifts complement(3534073) /Source="Nicolas_upshifts" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="upshifts" promotor_-35 complement(3534092..3534099) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-35" CDS 3534113..3534868 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 11807058, 18310071, 24878601, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 11807058, 18310071, 24878601, 26735940; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the iol operon (DeoR family)" /protein_id="NP_391856.1" /db_xref="EnsemblGenomes-Gn:BSU39770" /db_xref="EnsemblGenomes-Tr:CAB16013" /db_xref="GOA:P46337" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11364" /db_xref="UniProtKB/Swiss-Prot:P46337" /translation="MKLMRIQEMEEYILSHGTVSLDELCQVFNVSKNTVRRDINKLTE KGAIEKVYGGVTSIEKTALVPFENRTIQHQDEKTKIAHYASRFIEDHDLVFIDSGTTT KSILDTLDPAKNVTILTNSLDIINAASALKNINLIIIGNNYKRKTRSFVGMDDPAMLD KYNINKAFMSATGTTLTHGLTNSDLLEYEIKKRISEKAKEVYLLADHSKFGKSTLLTY APFDRLHCIVTSQPLDDEYTQYCNEHQIGIHLA*" /label="iolR CDS" gene 3534113..3534868 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" /label="iolR gene" promotor_-35 3534847..3534853 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3534868..3534887 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3534882 /Source="Nicolas_upshifts" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="upshifts" CDS 3534922..3535854 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9226270, 15019785, 22720735, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_391857.1" /db_xref="EnsemblGenomes-Gn:BSU39780" /db_xref="EnsemblGenomes-Tr:CAB16014" /db_xref="GOA:P46336" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PYF" /db_xref="PDB:1PZ0" /db_xref="SubtiList:BG11363" /db_xref="UniProtKB/Swiss-Prot:P46336" /translation="MKKAKLGKSDLQVFPIGLGTNAVGGHNLYPNLNEETGKELVREA IRNGVTMLDTAYIYGIGRSEELIGEVLREFNREDVVIATKAAHRKQGNDFVFDNSPDF LKKSVDESLKRLNTDYIDLFYIHFPDEHTPKDEAVNALNEMKKAGKIRSIGVSNFSLE QLKEANKDGLVDVLQGEYNLLNREAEKTFFPYTKEHNISFIPYFPLVSGLLAGKYTED TTFPEGDLRNEQEHFKGERFKENIRKVNKLAPIAEKHNVDIPHIVLAWYLARPEIDIL IPGAKRADQLIDNIKTADVTLSQEDISFIDKLFA*" /label="iolS CDS" gene 3534922..3535854 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" /label="iolS gene" downshifts 3535856 /Source="Nicolas_upshifts" /id="D2054" /incds=0 /nref=154 /ntot=259 /MaxReadThrough="4.521" /MaxDrop="7.17874" /score="39.70215" /energy="-17.1" /TU="U3129" /idTUdmin="U3127" /TUdmin=6 /isTUend="TRUE" /label="downshifts" promotor_-35 3535933..3535940 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3535954..3535973 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3535960..3536115 /Source="Nicolas_S_feature" /locus_tag="new_4086646_4086801" /HighExp="dia5, LPhT, Diami, Etha, dia15, LBGstat, M9-stat, Lbtran, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.835, 0.994" /TUlongSig="SigA" /TUlongPSig="0.99" /label="S1529" upshifts 3535960 /Source="Nicolas_upshifts" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="upshifts" CDS 3536116..3536766 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391858.1" /db_xref="EnsemblGenomes-Gn:BSU39790" /db_xref="EnsemblGenomes-Tr:CAB16015" /db_xref="GOA:P46335" /db_xref="SubtiList:BG11362" /db_xref="UniProtKB/Swiss-Prot:P46335" /translation="MKLKYVKALVAVTVALGVLLPSTISHAKSFSGRSSSSYSSRSSS SSYSGSYKSSPKSSYSSGSSSSSKKSKTSDDSSSSISLKKKPSEKASSSSSKKSSGTF SGATSKVTGKTYSGKTSKAYVGGRYVSVNHYYHAGFAPSGWFGYYSGFTMGMFMISMM HPWGYTYHPVGGPGYVSYGASPIAWIVDIIALIIILIIVIALIRAFKAPKTYRRRF*" /label="yxcE CDS" gene 3536116..3536766 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" /label="yxcE gene" CDS 3536770..3537078 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391859.1" /db_xref="EnsemblGenomes-Gn:BSU39800" /db_xref="EnsemblGenomes-Tr:CAB16016" /db_xref="InterPro:IPR020516" /db_xref="SubtiList:BG11361" /db_xref="UniProtKB/Swiss-Prot:P46334" /translation="MRLILNEQEIVDGICVYISNEEDIYPEDVEVKELSYNKRTGFFA EATFGLHHKQLMSDDISEGIIQFLEEYHNFNPDVTVVELQFDKKKGFSALVFVNEAEE *" /label="yxcD CDS" gene 3536770..3537078 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" /label="yxcD gene" downshifts 3537080 /Source="Nicolas_upshifts" /id="D2055" /incds=0 /nref=185 /ntot=262 /MaxReadThrough="1.91541" /MaxDrop="6.4314" /score="14.1581732" /energy="-8.8" /TU="NA" /idTUdmin="U3130" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 3537222..3537228 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3537244..3537262 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3537254 /Source="Nicolas_upshifts" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="upshifts" CDS 3537316..3538701 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391860.1" /db_xref="EnsemblGenomes-Gn:BSU39810" /db_xref="EnsemblGenomes-Tr:CAB16017" /db_xref="GOA:P46333" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11360" /db_xref="UniProtKB/Swiss-Prot:P46333" /translation="MKKDTRKYMIYFFGALGGLLYGYDTGVISGALLFINNDIPLTTL TEGLVVSMLLLGAIFGSALSGTCSDRWGRRKVVFVLSIIFIIGALACAFSQTIGMLIA SRVILGLAVGGSTALVPVYLSEMAPTKIRGTLGTMNNLMIVTGILLAYIVNYLFTPFE AWRWMVGLAAVPAVLLLIGIAFMPESPRWLVKRGSEEEARRIMNITHDPKDIEMELAE MKQGEAEKKETTLGVLKAKWIRPMLLIGVGLAIFQQAVGINTVIYYAPTIFTKAGLGT SASALGTMGIGILNVIMCITAMILIDRVGRKKLLIWGSVGITLSLAALSGVLLTLGLS ASTAWMTVVFLGVYIVFYQATWGPVVWVLMPELFPSKARGAATGFTTLVLSAANLIVS LVFPLMLSAMGIAWVFMVFSVICLLSFFFAFYMVPETKGKSLEEIEASLKKRFKKKKS TQNQVLNERTL*" /label="csbC CDS" gene 3537316..3538701 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /label="csbC gene" downshifts 3538687 /Source="Nicolas_upshifts" /id="D2056" /incds=0 /nref=69 /ntot=115 /MaxReadThrough="4.59405" /MaxDrop="7.32264" /score="22.9943012" /energy="-16.4" /TU="NA" /idTUdmin="U3131" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 3538732..3539282 /Source="Nicolas_S_feature" /locus_tag="new_4089418_4089968" /HighExp="Etha, C30, C90, Gly, Sw, G135, Fru, HiTm, M/G, Mal" /AntisenseName="htpG" /AntisenseCor="7.4766600377621104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1530" CDS complement(3538743..3540623) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III heat-shock protein (ATP-dependent molecular chaperone HSP90)" /protein_id="NP_391861.1" /db_xref="EnsemblGenomes-Gn:BSU39820" /db_xref="EnsemblGenomes-Tr:CAB16018" /db_xref="GOA:P46208" /db_xref="InterPro:IPR001404" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR019805" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020575" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037196" /db_xref="SubtiList:BG11359" /db_xref="UniProtKB/Swiss-Prot:P46208" /translation="MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIY YKALTDDALTFDKDSYYIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAF KKENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPC EKDSVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEG SENEFEEVQEEQTVNSMVPIWRKNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGA VRYNAILFVPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPDHFSFVKGMVDSED LSLNISREMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVY NDFGANKDQLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKFIYYATGDSYDRIEKLPQT EMVADKGYEILYFTEDIDEFAIKMLASYQEKEFKSVSSGDLGIDTDEDQKQSEEEESK YKDLFEEMKNILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDSQNVKAE KVLEINPNHEVFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKV MV*" /label="htpG CDS" gene complement(3538743..3540623) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /label="htpG gene" downshifts complement(3538749) /Source="Nicolas_upshifts" /id="D2057" /incds=0 /nref=169 /ntot=288 /MaxReadThrough="0.81611" /MaxDrop="6.49379" /score="34.0973015" /energy="-16.4" /TU="NA" /idTUdmin="U3132" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" S_feature complement(3540624..3540721) /Source="Nicolas_S_feature" /locus_tag="new_4091310_4091407_c" /HighExp="Lbtran, S1, LBGtran, C90, M40t45, M9-tran, GM 150, dia0, T-2.40H, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="SigA" /TUlongPSig="0.995" /label="S1531" promotor_-10 complement(3540712..3540731) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3540721) /Source="Nicolas_upshifts" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3540746..3540753) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3540791..3541042) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391862.1" /db_xref="EnsemblGenomes-Gn:BSU39830" /db_xref="EnsemblGenomes-Tr:CAB16019" /db_xref="GOA:P46332" /db_xref="SubtiList:BG11358" /db_xref="UniProtKB/Swiss-Prot:P46332" /translation="MKVQHKKELKFYCIVTIPSAFVVLTVISFLLQEITFPVTASAFL NASWHNLLFLIPFGLFFYPVHIWMKREFGRWNDTEKKRG*" /label="yxcA CDS" gene complement(3540791..3541042) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /label="yxcA gene" downshifts complement(3540809) /Source="Nicolas_upshifts" /id="D2058" /incds=0 /nref=11 /ntot=62 /MaxReadThrough="3.50049" /MaxDrop="5.56962" /score="-3.89567108" /energy="-6.7" /TU="U3133" /idTUdmin="U3133" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" misc_feature complement(3541064..3541083) /Source="Nicolas_upshift_promotors" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3541073) /Source="Nicolas_upshifts" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="upshifts" promotor_-35 3541106..3541112 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3541126..3541144 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3541127 /Source="Nicolas_upshifts" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="upshifts" CDS 3541159..3541980 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391863.2" /db_xref="EnsemblGenomes-Gn:BSU39840" /db_xref="EnsemblGenomes-Tr:CAB16020" /db_xref="GOA:P46331" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11357" /db_xref="UniProtKB/Swiss-Prot:P46331" /translation="MGRLENKTAVITGAATGIGQATAEVFANEGARVIIGDINKDQME ETVDAIRKNGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHE YPVDLFDRIIAVDLRGTFLCSKYLIPLMLENGGSIINTSSMSGRAADLDRSGYNAAKG GITNLTKAMAIDYARNGIRVNSISPGTIETPLIDKLAGTKEQEMGEQFREANKWITPL GRLGQPKEMATVALFLASDDSSYVTGEDITADGGIMAYTWPGKMLIEEKWKEETK*" /label="yxbG CDS" gene 3541159..3541980 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /label="yxbG gene" downshifts 3541964 /Source="Nicolas_upshifts" /id="D2059" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="2.87575" /MaxDrop="5.67438" /score="22.9485028" /energy="-10.5" /TU="U3134" /idTUdmin="U3134" /TUdmin="-221" /isTUend="FALSE" /label="downshifts" CDS complement(3542009..3543151) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11160890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391864.1" /db_xref="EnsemblGenomes-Gn:BSU39850" /db_xref="EnsemblGenomes-Tr:CAB16021" /db_xref="GOA:P46330" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG11356" /db_xref="UniProtKB/Swiss-Prot:P46330" /translation="MPESAEAQVKEALLALLKDRDIQHITMKEIAEKAKVSRGSLYLY YEDKFSIIEDVIEDMKEGLGKALFDAFSHMDTLHLNKKRQTVHPTLSFVHEHRSFFSV MMNRGHFHRFFKDVFQQDVLLAPIHVNLTPIERDIYGHYRALYTYAIILYWLNEDAAA SPEAISQKVWELVSQKRFYWLFGKAVPGEREKEKQIDRRVVRTREALQKAFLDVLAEK QDYAGITISDITRKSNIRRATFYDHYANKEELLQTMIQRSCAEIIDHLTIASSPNEFS LKEAEKALAILLSALSNMPIVHFLNREWGVPHVIPDMFKALESFYLHQQTDIHAEKKL YAHYVSAMIIGLLLYRLDEGKAHPPEVLAREFLQFLDVKKYKVVLL*" /label="yxbF CDS" gene complement(3542009..3543151) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /label="yxbF gene" downshifts complement(3542019) /Source="Nicolas_upshifts" /id="D2060" /incds=0 /nref=10 /ntot=163 /MaxReadThrough="1.63217" /MaxDrop="3.79969" /score="-0.564494299" /energy="-10.5" /TU="NA" /idTUdmin="U3135" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3543152..3543251) /Source="Nicolas_S_feature" /locus_tag="new_4093838_4093937_c" /HighExp="H2O2, Diami, dia15, Paraq, G180, G135, G150, dia5, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1532" promotor_-10 complement(3543239..3543258) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3543250) /Source="Nicolas_upshifts" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3543272..3543279) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3543294..3544631 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /EC_number="1.2.1.3" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391865.2" /db_xref="EnsemblGenomes-Gn:BSU39860" /db_xref="EnsemblGenomes-Tr:CAB16022" /db_xref="GOA:P46329" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11355" /db_xref="UniProtKB/Swiss-Prot:P46329" /translation="MEQQVKDDIQRVFQLQKKQQKALRASTAEQRREKLQRFLDSVIA HEEEIIEAIRKDVRKPYHEVKKAEIEGTKKAIRDNMNNLEQWMAPKEVGSSLSPDANG ILMYEPKGVTLILGPWNYPFMLTMAPLAASLAAGNSAIVKLSDFTMNTSNIAAKVIRD AFDEKEVAIFEGEVEVATELLDQPFDHIFFTGSTNVGKIVMTAAAKHLASVTLELGGK SPTIIDSEYDLMDAAKKIAVGKFVNAGQTCIAPDYLFIKKDVQDRFAGILQTVVNAGF MEDDHTPDRSKFTQIVNDRNFNRVKDLFDDAIERGAEVVFGGVFDASDRTISPTVLKN VTPDMKIMQEEIFASILPMMNYEDIDEVIDYVNDRDKPLALYVFSKNQDLIDNVLQHT TSGNAAINDVVVHFSDVNLPFGGVNTSGIGSYHGVYGFKEFSHEKGVFIQAAE*" /label="aldX CDS" gene 3543294..3544631 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /label="aldX gene" S_feature complement(3544036..3544636) /Source="Nicolas_S_feature" /locus_tag="new_4094722_4095322_c" /HighExp="T1.30H, T2.30H, T2.0H, T1.0H, T-2.40H, T3.0H, T3.30H, T0.0H, T-0.40H, T-3.40H" /AntisenseName="aldX" /AntisenseCor="-0.39894728806999702" /AntisenseRegPval="-11" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1533" CDS complement(3544670..3545149) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391866.2" /db_xref="EnsemblGenomes-Gn:BSU39870" /db_xref="EnsemblGenomes-Tr:CAB16023" /db_xref="GOA:P46328" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11354" /db_xref="UniProtKB/Swiss-Prot:P46328" /translation="MNIIPTCQVPKDLVSAFFQKHWGSPQMVISSGIYNCDELDGYGM LNDDNQIVGLITYIFEEDACEIISLDSVIENKGIGTALLEKAEEACRERNIKQIKLIT TNDNIHALAFYQKRGYRLDRLFVNAVETARKMKPEIPLLADNKIPIRDELLLVKELQ* " /label="yxbD CDS" gene complement(3544670..3545149) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /label="yxbD gene" downshifts complement(3544681) /Source="Nicolas_upshifts" /id="D2061" /incds=0 /nref=1 /ntot=39 /MaxReadThrough="3.82941" /MaxDrop="2.52984" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3545229..3546221) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391867.1" /db_xref="EnsemblGenomes-Gn:BSU39880" /db_xref="EnsemblGenomes-Tr:CAB16024" /db_xref="GOA:P46327" /db_xref="InterPro:IPR003347" /db_xref="PDB:1VRB" /db_xref="SubtiList:BG11353" /db_xref="UniProtKB/Swiss-Prot:P46327" /translation="MSAVTESVLESIISPVTMSEFLEEYWPVKPLVARGEVERFTSIP GFEKVRTLENVLAIYNNPVMVVGDAVIEESEGITDRFLVSPAEALEWYEKGAALEFDF TDLFIPQVRRWIEKLKAELRLPAGTSSKAIVYAAKNGGGFKAHFDAYTNLIFQIQGEK TWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLPDAEIVNLTPGTMLYL PRGLWHSTKSDQATLALNITFGQPAWLDLMLAALRKKLISDNRFRELAVNHQSLHESS KSELNGYLESLIQTLSENAETLTPEQIFQSQDSDFDPYQSTQLVFRQLLTSYKF*" /label="yxbC CDS" gene complement(3545229..3546221) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /label="yxbC gene" downshifts complement(3545253) /Source="Nicolas_upshifts" /id="D2062" /incds=0 /nref=5 /ntot=98 /MaxReadThrough="5.86537" /MaxDrop="5.28716" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-1188" /isTUend="FALSE" /label="downshifts" downshifts 3546211 /Source="Nicolas_upshifts" /id="D2063" /incds=0 /nref=2 /ntot=56 /MaxReadThrough="1.15059" /MaxDrop="3.74519" /score="9.93493822" /energy="-12.4" /TU="NA" /idTUdmin="U3134" /TUdmin=4026 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3546244..3546263) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3546262) /Source="Nicolas_upshifts" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3546278..3546285) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3546284..3546291 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3546305..3546729 /Source="Nicolas_S_feature" /locus_tag="new_4096991_4097415" /HighExp="T2.0H, T5.0H, M9-stat, T3.0H, T1.30H, T1.0H, T3.30H, T2.30H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998942" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1534" upshifts 3546305 /Source="Nicolas_upshifts" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3546306..3546325 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 3546311..3546723 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /product="putative small RNA or mRNA leader sequence" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="srlX RNA" gene 3546311..3546723 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /label="srlX gene" upshifts complement(3546331) /Source="Nicolas_upshifts" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3546341..3546355) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3546363..3546367) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3546695 /Source="Nicolas_upshifts" /id="D2064" /incds=0 /nref=2 /ntot=9 /MaxReadThrough="8.39077" /MaxDrop="5.02548" /score="9.93493822" /energy="-12.4" /TU="U3137" /idTUdmin="U3134" /TUdmin=4510 /isTUend="FALSE" /label="downshifts" CDS 3546730..3547464 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /EC_number="2.1.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941984, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_391868.1" /db_xref="EnsemblGenomes-Gn:BSU39890" /db_xref="EnsemblGenomes-Tr:CAB16025" /db_xref="GOA:P46326" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11352" /db_xref="UniProtKB/Swiss-Prot:P46326" /translation="MITAEECRTYKEFVDLYQSYLYPLLGARLSRMYSPKNKVIIDMG TGPGYLSIQLAKRTNAHVHAVDINPAMHEIAQEEAKKSGVSSLISFDLEDVHHLSYAD QYADFIVSYSCLHHWEDVVKGLKECYRVLAPGGKIVILDTFNPQGSHLEIMRKQIKEP EYFRFVREAFEESYSFEDIHQFVQDAGIPNYSLETFHFLPEDFIESLDELEDAPLWEQ NDQSTDHEIESVTWMLTIEKEKEGAL*" /label="yxbB CDS" gene 3546730..3547464 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /label="yxbB gene" CDS 3547464..3547733 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17083466" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391869.1" /db_xref="EnsemblGenomes-Gn:BSU39900" /db_xref="EnsemblGenomes-Tr:CAB16026" /db_xref="InterPro:IPR008792" /db_xref="SubtiList:BG11351" /db_xref="UniProtKB/Swiss-Prot:P46325" /translation="MINESTVLSKNPEMPSRKYLKSIIIEPGITLNEMASDIYNHIDG KVSIHDICSKIVNEYDVDYQTCLEDCMELFELLIDHEAIKVKQGA*" /label="yxbA CDS" gene 3547464..3547733 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /label="yxbA gene" CDS 3547737..3548219 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20185509" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391870.1" /db_xref="EnsemblGenomes-Gn:BSU39910" /db_xref="EnsemblGenomes-Tr:CAB16027" /db_xref="SubtiList:BG14166" /db_xref="UniProtKB/Swiss-Prot:O34704" /translation="MEKQKVLALPDDVHELSTHRSKSIVNYIITLLAFAKKQGLTHQD IVSWIHEQYEERGYYDEWRHINSQQPVGSFVELFIKGRRLLYDKIELFETEDKYVVNT HTWYEKEPSEAFFYFEIDPEEFSAYASILAIENAKRLGIKIDIVKETDVETAYIYKHQ *" /label="yxnB CDS" gene 3547737..3548219 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /label="yxnB gene" CDS 3548240..3550483 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /EC_number="6.3.5.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 17083466, 20185509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 17083466, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (glutamine-hydrolyzing)" /protein_id="NP_391871.2" /db_xref="EnsemblGenomes-Gn:BSU39920" /db_xref="EnsemblGenomes-Tr:CAB16028" /db_xref="GOA:P42113" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11116" /db_xref="UniProtKB/Swiss-Prot:P42113" /translation="MCGLAGIINLAAPRSQECTFHILKGMADAISYRGPDDEQYHIDS KVGFAFRRLSILDLVNGQQPFLNEDGSIVVMVNGEIYNYKELKASLHNHMFKTTSDCE VIVHLYEEKGIGFVDDIIGMFSIAIWDKNKNKVFLVRDRFGIKPLFYTELKHELIFAS EIKSLFSHPHCPRQFNWKEALSDIWLSGEAASNHKETTSFFVNIQNLDAGHYLEINLT TNERKTASYWSLQDILLRQGYRENLHPDDLIEGYRELLADSVHRCLQSDVEVGLFLSG GIDSAAVAHFAAEKQDLHTFTVLSQSTFTNEDAKYAHWLAKDLHLPNHQVLYQLGNDE LLQPESYKHLLWICETPFCGPEQLYKFHLHKYAKAIRPNLKVMLTGQGSDEFNGGYST TLSPAENPSWEGFIESVNTMEMNRLHRLQGNIFRVWEEHFGLSPINLSYLKSNDSSQA DPWQSYVLTKYRDLQMYNCWHEDRIAAANHIENRVPFLDHRLVEWVCGIPDGLRKDLL WDKSVLRKSLTNELHTSYTHRPKVPFFYGKDVRYTHKMMFHLLKKNNYQLIEEAFSHS DASSIIQVEHIHAIMTYLEDDPEFTNFEFLLRLVNMGLLSKMTKETPSVQLDITSHLE SITIKDWHSQEGDIASRLNISANKCEGQDILALNPGVTLLRPESDSEHCIYIAEEGFI QFIVSEEDVGAWLHILCDINGKDTLHTILDRHGVSLEEVAKYIQEAIEHNIILIKQKN LPEGAYR*" /label="asnH CDS" gene 3548240..3550483 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /label="asnH gene" CDS 3550480..3551679 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989, 15849754, 16850406, 20185509; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391872.2" /db_xref="EnsemblGenomes-Gn:BSU39930" /db_xref="EnsemblGenomes-Tr:CAB16029" /db_xref="GOA:P42112" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11115" /db_xref="UniProtKB/Swiss-Prot:P42112" /translation="MSIFYSFSALRGLAMGIFSPIWILYLISKDYDFLQIGLMGAVLE IAKLIFEVPSGVFADRYGIKISIASSFFFSILTWAFFPFIDSAAICILAMIIWALSDS LISGSFETWMSRVAGEDRFGKEMMKNTQLLITFLIIGSIASGYLYSLNIYFPFLLVMV IYLLLFIWMSVFIKVPSVSETNHGDQNQHDSIKIIKESLKIIFNKKRVLLIVIAGFFT ATAYDTISRYWQPFLSDLGFSEKSLGYIFALGGFTALVLLTLTIRFEKKIEKNPYLAL TSLDSMGMVMTFLLSRAFRPLGIPCTAFLLAIEDIHHPIVTSYLNKFFPDSYKNTLFS LNSGVGAIGEILSGVIFGIISAAFGLSAMFVVVAVFLLIPIILYTIVPKIKDNDMKVQ IEKSQQV*" /label="yxaM CDS" gene 3550480..3551679 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /label="yxaM gene" promotor_-10 complement(3551435..3551453) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3551457) /Source="Nicolas_upshifts" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3551468..3551474) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3551670 /Source="Nicolas_upshifts" /id="D2065" /incds=0 /nref=71 /ntot=174 /MaxReadThrough="3.22879" /MaxDrop="5.42242" /score="-6.94914943" /energy="-8.5" /TU="U3137" /idTUdmin="U3137" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts complement(3551743) /Source="Nicolas_upshifts" /id="D2066" /incds=0 /nref=156 /ntot=227 /MaxReadThrough="3.53794" /MaxDrop="6.77896" /score="7.32872401" /energy="-16.9" /TU="U3140" /idTUdmin="U3141" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3551743..3552975) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 15743949, 17060472, 18165306, 22720735, 26060272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane associated protein kinase with beta-propeller domain" /protein_id="NP_391873.2" /db_xref="EnsemblGenomes-Gn:BSU39940" /db_xref="EnsemblGenomes-Tr:CAB16030" /db_xref="GOA:P42111" /db_xref="InterPro:IPR002372" /db_xref="InterPro:IPR011047" /db_xref="InterPro:IPR018391" /db_xref="SubtiList:BG11114" /db_xref="UniProtKB/Swiss-Prot:P42111" /translation="MVKSFRMKALIAGAAVAAAVSAGAVSDVPAAKVLQPTAAYAAET VFSQNNGASGFLPGRYDVQAMAPAMFNWSRESRFAGNTDGTLKWQNDIRTTPQNGAGA VIDGDGTVYLHSRDGEMKAFNPDGSVKWVTGNLGKTYTQSPVLGTNGVIYLASYDKKI YFIDKETGEILTTVPLSGGPSSETVIGSDGTLYFSTLDNYVHAIKPTSKSTWTERWKL KTNGVVSSVPVLAKNGTVYVGTYNYVFYAINSGTGQVKWSRTTSNAFKGYPVIDKDGN IYAGNQDGQLYAYTSTGSLKWTFPLNGFSSSSPAIDHNGNIYIGSGSGELFSISKNGD MNWSFYTDGPVRTAPLIDAKGTVYFGSDDMKVYAADANGNELWSYQTDSNVVSSPQLA EDGTLYIGSYTKLMAFGK*" /label="yxaL CDS" gene complement(3551743..3552975) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /label="yxaL gene" promotor_-10 complement(3553007..3553026) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3553019) /Source="Nicolas_upshifts" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3553040..3553045) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3553076..3553501) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949, 15849754, 16850406, 27902860; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391875.2" /db_xref="EnsemblGenomes-Gn:BSU39950" /db_xref="EnsemblGenomes-Tr:CAB16032" /db_xref="GOA:P42109" /db_xref="InterPro:IPR020204" /db_xref="SubtiList:BG11112" /db_xref="UniProtKB/Swiss-Prot:P42109" /translation="MSKKNSVAIMTTISAFLFCAVIVAASLSPLAGTGAAANQFNSAG MWSAVGMILVLYFIPFLVYMLGVDAMRYVMAVLCGFGLLIHLSSAGFILMFSFFSDHL LSEVIFVLGVSLAAAAVNVIWFVAAFRSGAEKTSVNTLT*" /label="yxaJ CDS" gene complement(3553076..3553501) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /label="yxaJ gene" promotor_-10 complement(3553529..3553548) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3553543) /Source="Nicolas_upshifts" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3553561..3553567) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3553693..3553700 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3553710 /Source="Nicolas_upshifts" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3553715..3553734 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3553758..3554213 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391876.1" /db_xref="EnsemblGenomes-Gn:BSU39960" /db_xref="EnsemblGenomes-Tr:CAB16033" /db_xref="GOA:P42108" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11111" /db_xref="UniProtKB/Swiss-Prot:P42108" /translation="MEKPAGFWIRFLAYFIDGIIVSVPSYIILFIINSVFVAGAVATN PYMTEEEYLVKYMTLAFLPTMLIMIVISVLYYGLLTASKMQGTLGKKILGLKVVNEQG ERVSVGQGIGRYFAYILSGIIFYIGFIMIAFGEKKGLHDIICKTRVVYK*" /label="yxaI CDS" gene 3553758..3554213 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /label="yxaI gene" downshifts 3554151 /Source="Nicolas_upshifts" /id="D2067" /incds=1 /nref=58 /ntot=234 /MaxReadThrough="3.24719" /MaxDrop="5.4441" /score="18.1083522" /energy="-13.4" /TU="U3142" /idTUdmin="U3142" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" S_feature 3554214..3554827 /Source="Nicolas_S_feature" /locus_tag="new_4104900_4105513" /HighExp="LPh, HPh, MG 60, BMM, MG t5, G180, MG 45, G150, MG-0.2, MG 10" /AntisenseName="yxaH" /AntisenseCor="0.37646026982403002" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1535" CDS complement(3554243..3555451) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein involved in response to flavonoids" /protein_id="NP_391877.2" /db_xref="EnsemblGenomes-Gn:BSU39970" /db_xref="EnsemblGenomes-Tr:CAB16034" /db_xref="GOA:P42107" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11110" /db_xref="UniProtKB/Swiss-Prot:P42107" /translation="MSSLQPTLTNERIGVLDVLRGMAIFGILFVNLAHFSYPDMYLSM LGKENFFMDKWSEADFAAADILKFFIQTKCILLFSFLFGFGMVVMMERAENKGKRFVP LYVRRLMALLLFGTIHAFLIWDGDILTEYALLGFVLLLFRKAKPKTLLIWAVSLYLLF SIPFMLTSFDQSNGQEWVQAVTQQAKQAIHVYGSGSLKDIAEQRIHDRLVYMSSNGML TYNPLNYFFASIPYFSMFLLGAAAAKSRYLHEPEKHRKGLKRLWMAGLVIGIGAQVLY SVTDKEICLLIGAPFLMFFYVTTVVYLYHKTRVRTVLQSFSAVGRMAFTNYLMQSIVC TWIFYHYGLGLYGKVYPAAGVLITIAVCAVQMVFSHLWLRVFRMGPFEWLWRSATYLS WQPIAKKTKV*" /label="yxaH CDS" gene complement(3554243..3555451) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /label="yxaH gene" downshifts complement(3554270) /Source="Nicolas_upshifts" /id="D2068" /incds=0 /nref=14 /ntot=66 /MaxReadThrough="0.30987" /MaxDrop="3.782" /score="34.1593124" /energy="-16.2" /TU="NA" /idTUdmin="U3143" /TUdmin=286 /isTUend="FALSE" /label="downshifts" S_feature complement(3555452..3555558) /Source="Nicolas_S_feature" /locus_tag="new_4106138_4106244_c" /HighExp="T-5.40H, T-4.40H, SMMPr, T-2.40H, T-3.40H, T-1.40H, Sw, T0.0H, Pyr, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1536" CDS complement(3555559..3556572) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /EC_number="1.13.11.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quercetin dioxygenase" /protein_id="NP_391878.2" /db_xref="EnsemblGenomes-Gn:BSU39980" /db_xref="EnsemblGenomes-Tr:CAB16035" /db_xref="GOA:P42106" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:1Y3T" /db_xref="PDB:2H0V" /db_xref="SubtiList:BG11109" /db_xref="UniProtKB/Swiss-Prot:P42106" /translation="MKTLCTHSLPKEKMPYLLRSGEGERYLFGRQVATVMANGRSTGD LFEIVLLSGGKGDAFPLHVHKDTHEGILVLDGKLELTLDGERYLLISGDYANIPAGTP HSYRMQSHRTRLVSYTMKGNVAHLYSVIGNPYDHAEHPPYASEEVSNERFAEAAAVAD IVFLDEAKPACSAKLAELTELPDGAVPYVLESGEGDRLLTGDQLHRIVAAQKNTDGQF IVVSSEGPKGDRIVDHYHEYHTETFYCLEGQMTMWTDGQEIQLNPGDFLHVPANTVHS YRLDSHYTKMVGVLVPGLFEPFFRTLGDPYEGHIFPCEPQALRFDRILQNIEALDLKV MKP*" /label="qdoI CDS" gene complement(3555559..3556572) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /label="qdoI gene" S_feature complement(3556573..3556646) /Source="Nicolas_S_feature" /locus_tag="new_4107259_4107332_c" /HighExp="T-3.40H, T-5.40H, T-1.40H, T-2.40H, T-4.40H, T-0.40H, T0.0H, Pyr, SMMPr, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1537" promotor_-10 complement(3556631..3556650) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3556646) /Source="Nicolas_upshifts" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3556663..3556670) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3556666..3557241) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17483215, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483215, 21737930; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of qdoI" /protein_id="NP_391879.2" /db_xref="EnsemblGenomes-Gn:BSU39990" /db_xref="EnsemblGenomes-Tr:CAB16036" /db_xref="GOA:P42105" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1SGM" /db_xref="SubtiList:BG11108" /db_xref="UniProtKB/Swiss-Prot:P42105" /translation="MTSRGDSREKILHTASRLFQLQGYHATGLNQIVKESGAPKGSLY HFFPNGKEELAIEAVTYTGKIVEHLIQQSMDESSDPVEAIQLFIKKTASQFDNTESIK GIPVGLLASETALISEPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMI EGGIMLSLTNKDKTPLLLIAEQIPVLVRKKG*" /label="qdoR CDS" gene complement(3556666..3557241) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /label="qdoR gene" downshifts complement(3556690) /Source="Nicolas_upshifts" /id="D2069" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="1.66581" /MaxDrop="2.62803" /score="-2.51956315" /energy="-8.8" /TU="NA" /idTUdmin="U3144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3557270..3557289) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3557284) /Source="Nicolas_upshifts" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3557304..3557311) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3557312..3557318 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3557333..3557351 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3557340 /Source="Nicolas_upshifts" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="upshifts" CDS 3557372..3558442 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391880.2" /db_xref="EnsemblGenomes-Gn:BSU40000" /db_xref="EnsemblGenomes-Tr:CAB16037" /db_xref="GOA:O32291" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14165" /db_xref="UniProtKB/Swiss-Prot:O32291" /translation="MTIDHSVTNTEQLEQQNPAIKTKLKLKKLKDQVIVITGASSGIG LVTARMAAEKGAKVVAAARNEEALKELTDELKEKGHDAIWVKADVGKEEDVNRIAETA ISTFGRFDTWVNNAAVSTFGHAMDVTVEDMKRMFDTNFWGPVYGTRAAVKHYTGRGVP GALINVGSLFGDRGTVIQSTYASAKFALHGWTESIRMELEKEQAPVSVTLIHPGRIDT PYNEHAHSYLDKQPAHYRSMIYPPEAVAEAILFAAEHPKRDMYIGSQAKAIAMLGALF PRLTDRLMEKIMYHSQHAERPSNPREESALYDAGCGMHDRGTNKGWMRSRSYYTKATK RPIVSAAVVAGLVAWAAAKRCR*" /label="yxnA CDS" gene 3557372..3558442 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /label="yxnA gene" downshifts 3558440 /Source="Nicolas_upshifts" /id="D2070" /incds=0 /nref=7 /ntot=44 /MaxReadThrough="2.68466" /MaxDrop="3.96227" /score="-3.48213422" /energy="-11.2" /TU="NA" /idTUdmin="U3145" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3558499..3558930) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391881.1" /db_xref="EnsemblGenomes-Gn:BSU40010" /db_xref="EnsemblGenomes-Tr:CAB16038" /db_xref="GOA:P42103" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11106" /db_xref="UniProtKB/Swiss-Prot:P42103" /translation="MQNQNPVELIEYELTTFIRRAVYLDQSEKRTGNLERSSYLLLRQ LDEFGPARVKELAESFKLDISTLSRQAAALEAKELIYRFSDPSDGRVSLFTITKLGKQ LLKADQQKRLERYEQMLKEWSTQEKEMFGELLQRMNKAFID*" /label="yxaD CDS" gene complement(3558499..3558930) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /label="yxaD gene" promotor_-35 3558960..3558967 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3558981..3559000 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3558990..3559156 /Source="Nicolas_S_feature" /locus_tag="new_4109676_4109842" /HighExp="LBGstat, Cold, Heat, Salt, Etha, H2O2, G180, LBGtran, GM 150, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1538" upshifts 3558990 /Source="Nicolas_upshifts" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3559042..3559061) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3559062) /Source="Nicolas_upshifts" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3559076..3559083) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3559157..3559561 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein involved in export murein hydrolases" /protein_id="YP_003097798.1" /db_xref="EnsemblGenomes-Gn:BSU40021" /db_xref="EnsemblGenomes-Tr:CAX52713" /db_xref="GOA:C0H3T7" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR036640" /db_xref="UniProtKB/Swiss-Prot:C0H3T7" /translation="MKVIRIILQVLILYVFFMIGEAIQHLFHLPVSGSIVGLVLLLIC LGLRIVPVSIIEDGAGFLLSFLPLLFIPAMTGVINYPSLISFNGLMLLITVVLSTIVT IIAAGFASQLLEKKAKKREEKEKCSKHVSRSL*" /label="yxzK CDS" gene 3559157..3559561 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /label="yxzK gene" S_feature complement(3559178..3560230) /Source="Nicolas_S_feature" /locus_tag="new_4109864_4110916_c" /HighExp="Etha, C30, H2O2, Salt, Paraq, GM 120, Diami, Oxctl, G180, Sw" /AntisenseName="yxaC" /AntisenseCor="0.145103505386703" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1539" CDS 3559531..3560223 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative murein hydrolase export regulator" /protein_id="NP_391882.3" /db_xref="EnsemblGenomes-Gn:BSU40022" /db_xref="EnsemblGenomes-Tr:CAB16039" /db_xref="GOA:P42102" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG11105" /db_xref="UniProtKB/Swiss-Prot:P42102" /translation="MQQACIAIIIILLTVAAYLAMVKLYKRFPLPFLIPVLTTTILIV AALMMFHVSYEGYMIGGKWINSLLGPAVVALAYPLYKQWHIIVKHCVPILGGVLVGLC MGMISGLIFAEAFGIDHDLLLSILPKSITTPVAIQIAAGLGGVPSMTVVFVMIAGFSG VILGPLFLKWLRIRSSLGQGIALGSASHALGTSKALEYGELAVSMSSVSMTLCAVLGS FFGPLVVWLFHI*" /label="yxaC CDS" gene 3559531..3560223 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /label="yxaC gene" CDS complement(3560263..3561294) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /EC_number="2.-.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9298659, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exopolysaccharide pyruvyl transferase (biofilm formation)" /protein_id="NP_391883.3" /db_xref="EnsemblGenomes-Gn:BSU40030" /db_xref="EnsemblGenomes-Tr:CAB16040" /db_xref="GOA:P42101" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11104" /db_xref="UniProtKB/Swiss-Prot:P42101" /translation="MTVQEIKGKKLVKGIAPNVEPEALLNDKRKVFLFGSPSYTNIGD QAIAYAEEKFIKNHFPYYEYIEIMDYATDEGIELVKEIIREDDIVCFTGGGNLGNLYL DIEEDRRKVFSAFKDYKSISLPQSVYFEDTEEGQKEKKKTQDAYHQNTNLTIAARETQ TLDVVKETFNSNVIFTPDMVLSLDIVPRELERDGVLFILRADKEKVTDEDFISQMKQW AEKTTYTERTDTVLDTVDTIDYADREKHFMEMLDRIGSSKLVITDRLHAMIFSIITKT PCLVFGNSYGKAKHSYRDWLESLNFIEYTDKNDVEELERMIDRLLQAEPNDVDLSKDF QPLIDFFAS*" /label="yxaB CDS" gene complement(3560263..3561294) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /label="yxaB gene" downshifts complement(3560275) /Source="Nicolas_upshifts" /id="D2071" /incds=0 /nref=5 /ntot=94 /MaxReadThrough="6.52386" /MaxDrop="4.6522" /score="17.8326496" /energy="-15.3" /TU="U3149" /idTUdmin="U3150" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-35 3561261..3561264 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3561277 /Source="Nicolas_upshifts" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3561281..3561300 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3561331..3561349) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3561349) /Source="Nicolas_upshifts" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3561364..3561370) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3561387..3562535) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /EC_number="2.7.1.31" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15771780, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-glycerate kinase" /protein_id="NP_391884.2" /db_xref="EnsemblGenomes-Gn:BSU40040" /db_xref="EnsemblGenomes-Tr:CAB16041" /db_xref="GOA:P42100" /db_xref="InterPro:IPR004381" /db_xref="InterPro:IPR018193" /db_xref="InterPro:IPR036129" /db_xref="SubtiList:BG11103" /db_xref="UniProtKB/Swiss-Prot:P42100" /translation="MKIIIAPDSFKESLSALEAAEAIERGFKSVFPGADYRKLPVADG GEGTVQSLVDATNGRIIEQVVTGPLGEPVRAFFGMMGDGRTAVIEMAAASGLHLVPVD KRNPLITTTRGTGELIGAALDAGAERLIIGIGGSATNDGGAGMIQALGGRLLDNSGSE IGPGGGALSQLASIDVSGLDSRLRNVKLEVACDVDNPLTGPKGATAVFGPQKGATADM LDVLDQNVSHFADMAEKALGSTFRDTEGAGAAGGLGWSLLTYLQADLKRGIDIVLEAV DFESIVQDADLVITGEGRIDSQTVHGKTPIGVAKAAKSYDVPVIGIAGSISRDSNAVY QHGIDALFSIVPGAVPLEDAFEHAAEYMERTARDIAASIKLAKTMFLI*" /label="glxK CDS" gene complement(3561387..3562535) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /label="glxK gene" promotor_-10 complement(3562574..3562593) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3562585) /Source="Nicolas_upshifts" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3562604..3562611) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3562657..3562664 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3562678..3562697 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3562685 /Source="Nicolas_upshifts" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3562731..3563462 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7476858, 7642511, 8655507, 9106211, 26151451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7476858, 7642511, 8655507, 9106211, 26151451; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR-gluconate)" /protein_id="NP_391885.1" /db_xref="EnsemblGenomes-Gn:BSU40050" /db_xref="EnsemblGenomes-Tr:CAB16042" /db_xref="GOA:P10585" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10648" /db_xref="UniProtKB/Swiss-Prot:P10585" /translation="MLDSKDLLYPAKWLSKASTGVRVAYELRMRIVSGLIESGTILSE NTIAAEFSVSRSPVREALKILASEKIIRLERMGAVVIGLTEKKIAEIYDVRLLLETFV FERLVKIDIEPLVKDLSKILEMMKVSIKYEDADEFSFQDVLFHETIIRAIDHSYIQMI WNNLKPVMESFILLSMRVRLKEKYEDFTRILDNHELYIQAIKTKDRALMIQSLHQNFD DVQDKVEDLWLSQQMLAKGAEYNND*" /label="gntR CDS" gene 3562731..3563462 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /label="gntR gene" CDS 3563455..3564996 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /EC_number="2.7.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1659648, 2537826, 3020045, 11468405" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1659648, 2537826, 3020045, 11468405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-gluconate kinase" /protein_id="NP_391886.1" /db_xref="EnsemblGenomes-Gn:BSU40060" /db_xref="EnsemblGenomes-Tr:CAB16043" /db_xref="GOA:P12011" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006002" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10649" /db_xref="UniProtKB/Swiss-Prot:P12011" /translation="MTSYMLGIDIGTTSTKAVLFSENGDVVQKESIGYPLYTPDISTA EQNPEEIFQAVIHTTARITKQHPEKRISFISFSSAMHSVIAIDENDKPLTPCITWADN RSEGWAHKIKEELNGHEVYKRTGTPIHPMAPLSKIAWITNERKEIASKAKKYIGIKEY IFKQLFNEYVIDYSLASATGMMNLKGLDWDEEALRIAGITPDHLSKLVPTTEIFQHCS PEIAIQMGIDPETPFVIGASDGVLSNLGVNAIKKGEIAVTIGTSGAIRTIIDKPQTDE KGRIFCYALTDKHWVIGGPVNNGGIVLRWIRDEFASSEIETATRLGIDPYDVLTKIAQ RVRPGSDGLLFHPYLAGERAPLWNPDVRGSFFGLTMSHKKEHMIRAALEGVIYNLYTV FLALTECMDGPVTRIQATGGFARSEVWRQMMSDIFESEVVVPESYESSCLGACILGLY ATGKIDSFDAVSDMIGSTYRHTPIEDSAKEYRTLMPIFINLSRLLENQYTQIADYQRG LITHK*" /label="gntK CDS" gene 3563455..3564996 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /label="gntK gene" CDS 3565025..3566371 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3020045, 15849754, 1659648, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3020045, 15849754, 1659648, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gluconate/proton permease" /protein_id="NP_391887.1" /db_xref="EnsemblGenomes-Gn:BSU40070" /db_xref="EnsemblGenomes-Tr:CAB16044" /db_xref="GOA:P12012" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG10650" /db_xref="UniProtKB/Swiss-Prot:P12012" /translation="MPLIIVALGILALLFLIMGLKLNTFISLLVVSFGVALALGMPFD KVVSSIEAGIGGTLGHIALIFGLGAMLGKLIADSGGAQRIAMTLVNKFGEKNIQWAVV IASFIIGIALFFEVGLVLLIPIVFAISRELKISILFLGIPMVAALSVTHGFLPPHPGP TAIAGEYGANIGEVLLYGFIVAVPTVLIAGPLFTKFAKKIVPASFAKNGNIASLGTQK TFNLEETPGFGISVFTAMLPIIIMSVATIIDLLQETIGFADNGVLAFIRLIGNASTAM IISLLVAVYTMGIKRNIPVKTVMDSCSTAISQIGMMLLIIGGGGAFKQVLINGGVGDY VADLFKGTALSPIILAWLIAAILRISLGSATVAALSTTGLVIPLLGHSDVNLALVVLA TGAGSVIASHVNDAGFWMFKEYFGLSMKETFATWTLLETIISVAGLGFILLLSLVV*" /label="gntP CDS" gene 3565025..3566371 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /label="gntP gene" promotor_-35 3565824..3565828 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3565844..3565863 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3565853 /Source="Nicolas_upshifts" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3566394..3567800 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /EC_number="1.1.1.343" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 9535092, 9931298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 9535092, 9931298; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconate dehydrogenase (NAD+-dependent)" /protein_id="NP_391888.1" /db_xref="EnsemblGenomes-Gn:BSU40080" /db_xref="EnsemblGenomes-Tr:CAB16045" /db_xref="GOA:P12013" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10651" /db_xref="UniProtKB/Swiss-Prot:P12013" /translation="MFNSIGVIGLGVMGSNIALNMANKGENVAVYNYTRDLTDQLIQK LDGQSLSPYYELEDFVQSLEKPRKIFLMVTAGKPVDSVIQSLKPLLEEGDVIMDGGNS HYEDTERRYDELKEKGIGYLGVGISGGEVGALTGPSIMPGGDRDVYEKAAPILTKIAA QVGDDPCCVYIGPKGAGHFTKMVHNGIEYADMQLIAEAYTFLRETLRLPLDEIASIFE TWNQGELKSYLIEITAEILRKKDEKTGQPLIDVILDKTGQKGTGKWTSMQAIDNGIPS TIITESLFARYLSSLKEERMAAQDVLAGPEAEEKHLDKDTWIEYVRQALYMGKVCAYA QGFAQYKMSSELYGWNLPLKDIALIFRGGCIIRADFLNVISEAFSEQPNLANLLIAPY FTDKLHAYQTGLRKVVCEGISTGISFPCLTTALSYYDGYRTGRSNANLLQAQRDYFGA HTYERTDMDGVFHTNWSE*" /label="gntZ CDS" gene 3566394..3567800 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /label="gntZ gene" downshifts 3567789 /Source="Nicolas_upshifts" /id="D2072" /incds=0 /nref=128 /ntot=228 /MaxReadThrough="3.81668" /MaxDrop="5.52642" /score="20.2280166" /energy="-10.2" /TU="NA" /idTUdmin="U3151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 3567897..3567916 /Source="Nicolas_upshift_promotors" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3567899..3568190 /Source="Nicolas_S_feature" /locus_tag="new_4118585_4118876" /HighExp="S8, Etha, Sw, T0.30H, Cold, H2O2, B60, S5, S4, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1540" upshifts 3567899 /Source="Nicolas_upshifts" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="upshifts" promotor_-35 3568163..3568170 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3568185..3568204 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3568192 /Source="Nicolas_upshifts" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3568214..3568221 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3568236..3568255 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3568239) /Source="Nicolas_upshifts" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3568242..3568256) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3568251 /Source="Nicolas_upshifts" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3568264..3568268) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3568264..3568827 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /EC_number="1.11.1.5" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932315, 14766928, 26322180" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932315, 14766928, 26322180; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (small subunit)" /protein_id="NP_391889.1" /db_xref="EnsemblGenomes-Gn:BSU40090" /db_xref="EnsemblGenomes-Tr:CAB16046" /db_xref="GOA:P80239" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017559" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11385" /db_xref="UniProtKB/Swiss-Prot:P80239" /translation="MSLIGKEVLPFEAKAFKNGEFIDVTNEDLKGQWSVFCFYPADFS FVCPTELEDLQEQYAALKELGVEVYSVSTDTHFVHKGWHDSSEKISKITYAMIGDPSQ TISRNFDVLDEETGLADRGTFIIDPDGVIQTVEINAGGIGRDASNLVNKVKAAQYVRQ NPGEVCPAKWEEGGETLTPSLDLVGKI*" /label="ahpC CDS" gene 3568264..3568827 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /label="ahpC gene" CDS 3568841..3570370 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /EC_number="1.6.99.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932314, 14766928, 16232966, 23899494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932314, 14766928, 16232966, 23899494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (large subunit)" /protein_id="NP_391890.1" /db_xref="EnsemblGenomes-Gn:BSU40100" /db_xref="EnsemblGenomes-Tr:CAB16047" /db_xref="GOA:P42974" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR012081" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11204" /db_xref="UniProtKB/Swiss-Prot:P42974" /translation="MVLDANIKAQLNQYMQLIENDIVLKVSAGEDDTSKDMLALVDEL ASMSSKISVEKAELNRTPSFSVNRVGEDTGVTFAGIPLGHEFTSLVLALLQVSGRPPK VDQKVIDQVKKISGEYHFESYISLTCHNCPDVVQALNMMSVLNPNITHTMIDGAAYKA EVESKNIMAVPTVYLNGESFGSGRMTLEEILAKMGSGTDASEFADKEPFDVLVVGGGP AGASAAIYTARKGIRTGVVAERFGGQVLDTMSIENFISVKATEGPKLAASLEEHVKEY DIDVMNLQRAKRLEKKDLFELELENGAVLKSKTVILSTGARWRNVNVPGEQEFKNKGV AYCPHCDGPLFEGKDVAVIGGGNSGIEAAIDLAGIVNHVTVLEFAPELKADEVLQKRL YSLPNVTVVKNAQTKEITGDQSVNGITYVDRETGEEKHVELQGVFVQIGLVPNTEWLE GTVERNRMGEIIVDKHGATSVPGLFAAGDCTDSAYNQIIISMGSGATAALGAFDYLIR N*" /label="ahpF CDS" gene 3568841..3570370 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /label="ahpF gene" downshifts complement(3570197) /Source="Nicolas_upshifts" /id="D2073" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="3.25325" /MaxDrop="3.69049" /score="1.76901559" /energy="-18" /TU="NA" /idTUdmin="U3157" /TUdmin=198 /isTUend="FALSE" /label="downshifts" downshifts 3570363 /Source="Nicolas_upshifts" /id="D2074" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="3.92009" /MaxDrop="8.88048" /score="33.1934883" /energy="-19.6" /TU="U3154" /idTUdmin="U3156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3570396..3570479) /Source="Nicolas_S_feature" /locus_tag="new_4121082_4121165_c" /HighExp="G150, C30, LPhT, G135, S8, LBGstat, T0.30H, G180, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1541" downshifts complement(3570439) /Source="Nicolas_upshifts" /id="D2075" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.37922" /MaxDrop="4.44094" /score="1.76901559" /energy="-18" /TU="U3157" /idTUdmin="U3157" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3570480..3571919) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8125345, 14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8125345, 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-6-phospho-beta-glucosidase" /protein_id="NP_391891.1" /db_xref="EnsemblGenomes-Gn:BSU40110" /db_xref="EnsemblGenomes-Tr:CAB16048" /db_xref="GOA:P42973" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11203" /db_xref="UniProtKB/Swiss-Prot:P42973" /translation="MGNMPKDFLWGGALAAHQFEGGWNQGGKGPSVVDVMTAGAHGVP RKITDTIEENEFYPNHEAIDFYHRYKEDIALFAEMGLKCLRTSIGWSRIFPKGDEAEP NEAGLQFYDDVFDELLKHGIEPVITLSHFEMPLHLAREYGGFRNRKVVDFFVNFAEAC FTRYKDKVKYWMTFNEINNQMDVNNPLFLWTNSGVVVGENENAKEVMYQTAHHELVAS ALAVAKGKDINPEFQIGAMVSHVPIYPFSSNPEDVMLAEEEMRQRYFFPDVQVRGYYP SYALKEFEREGYNITFEDGDDEILRNGTVDYLGFSYYMSTTVKSDVKNDNTGDIVNGG LPNGVENPYITSSDWGWAIDPTGLRYTLNRFYDRYQIPLFIVENGFGAVDTLEEDGKV HDPERIQYLKSHIEALKKAVTYDGVDLIGYTPWGIIDIVSFTTGEMKKRYGMIYVDRD NEGNGSMKRYKKDSFEWYKNVIQTNGEEL*" /label="bglA CDS" gene complement(3570480..3571919) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /label="bglA gene" CDS complement(3571933..3572163) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /EC_number="2.7.1.-" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867744, 28731580" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867744, 28731580; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucose phosphotransferase system enzyme IIA component" /protein_id="NP_391892.1" /db_xref="EnsemblGenomes-Gn:BSU40120" /db_xref="EnsemblGenomes-Tr:CAB16049" /db_xref="GOA:O32292" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG14172" /db_xref="UniProtKB/Swiss-Prot:O32292" /translation="MVTPTKHAIGLRSASGVELLAHIGLDTVTFDGTPFSLKVKEGDT VKKGEVLVEFDKAFIEDIEESALHQKIFTVVS*" /label="ptsJ CDS" gene complement(3571933..3572163) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /label="ptsJ gene" S_feature complement(3572164..3572375) /Source="Nicolas_S_feature" /locus_tag="new_4122850_4123061_c" /HighExp="G150, LPhT, T0.30H, Diami, G135, LBGstat, G180, Oxctl, Lbexp, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1542" promotor_-10 complement(3572372..3572391) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3572377) /Source="Nicolas_upshifts" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3572406..3572413) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3572439..3572446 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3572457..3572476 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3572472 /Source="Nicolas_upshifts" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="upshifts" CDS 3572507..3573217 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_391893.1" /db_xref="EnsemblGenomes-Gn:BSU40130" /db_xref="EnsemblGenomes-Tr:CAB16050" /db_xref="GOA:Q45591" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3BWG" /db_xref="SubtiList:BG11484" /db_xref="UniProtKB/Swiss-Prot:Q45591" /translation="MLKYQQIATEIETYIEEHQLQQGDKLPVLETLMAQFEVSKSTIT KSLELLEQKGAIFQVRGSGIFVRKHKRKGYISLLSNQGFKKDLEDFNVTSKVIELDVR KPTPEAAENLNIGMDEDIYYVKRVRYINGQTLCYEESYYTKSIVTYLNNEIVSHSIFH YIREGLGLKIGFSDLFLHVGQLNEEEAEYLGLEAGLPKLYIESIFHLTNGQPFDYSKI SYNYEQSQFVVQANSFLL*" /label="yydK CDS" gene 3572507..3573217 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /label="yydK gene" CDS 3573245..3573403 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097799.1" /db_xref="EnsemblGenomes-Gn:BSU40139" /db_xref="EnsemblGenomes-Tr:CAX52714" /db_xref="GOA:C0H3T8" /db_xref="UniProtKB/Swiss-Prot:C0H3T8" /translation="MYKIIIPAILAIFALWILLQISLEMSIVKNPMNYFIVFIIFFLF VKMVKEKQ*" /label="yyzN CDS" gene 3573245..3573403 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /label="yyzN gene" downshifts 3573480 /Source="Nicolas_upshifts" /id="D2076" /incds=0 /nref=16 /ntot=177 /MaxReadThrough="0.96913" /MaxDrop="4.2349" /score="-9.95345673" /energy="-14.7" /TU="NA" /idTUdmin="U3158" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3573534..3574256) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /function="16.1: Circulate" /function="16.3: Control" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="permease for export of regulatory peptide LiaD*" /protein_id="NP_391894.1" /db_xref="EnsemblGenomes-Gn:BSU40140" /db_xref="EnsemblGenomes-Tr:CAB16051" /db_xref="GOA:Q45592" /db_xref="SubtiList:BG11483" /db_xref="UniProtKB/Swiss-Prot:Q45592" /translation="MKLEFKKSISNKVIIILGAMFVFLFLLGYFLLVGIDKVSNVTPE MFFFSSYTVATQFGLMLFSFVIAFFINREYSNKNILFYKLIGENIYTFFYKKIAVLFL ECFAFITLGLLIISLMYHDFSHFALLLFLFSAVILQYILIIGTISVLCPNILISIGVS IVYWMTSVILVAISNKTFGFIAPFEAGNTMYPRIERVLQSDNMTLGSNDVLFIILYLV SIIIINAIVLRFSKTRWIKMGL*" /label="liaM CDS" gene complement(3573534..3574256) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /label="liaM gene" downshifts complement(3573546) /Source="Nicolas_upshifts" /id="D2077" /incds=0 /nref=225 /ntot=267 /MaxReadThrough="2.70741" /MaxDrop="6.21099" /score="7.49162587" /energy="-10.5" /TU="NA" /idTUdmin="U3160" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-35 3574157..3574160 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3574176..3574180 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3574191 /Source="Nicolas_upshifts" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3574277..3574906) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter for regulatory peptide LiaD* (ATP-binding protein)" /protein_id="NP_391895.1" /db_xref="EnsemblGenomes-Gn:BSU40150" /db_xref="EnsemblGenomes-Tr:CAB16052" /db_xref="GOA:Q45593" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11482" /db_xref="UniProtKB/Swiss-Prot:Q45593" /translation="MNIANYTLKVKGKTLLQDTDLHFSSGKINHVVGKNGVGKSQLAK DFLLNNSKRIGRDIRQNVSLISSSSNIPNDVSKDFLLHFLSKKFDAKMIDKIAYLLNL DNIDGKVLIKNLSDGQKQKLKLLSFLLEDKNIIVLDEITNSLDKKTVIEIHGFLNKYI QENPEKIIINITHDLSDLKAIEGDYYIFNHQEIQQYHSVDKLIEVYINE*" /label="liaL CDS" gene complement(3574277..3574906) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /label="liaL gene" S_feature complement(3574907..3575055) /Source="Nicolas_S_feature" /locus_tag="new_4125593_4125741_c" /HighExp="T-0.40H, LoTm, T-2.40H, T0.0H, M9-tran, SMMPr, T-1.40H, GM 150, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1543" CDS complement(3575056..3575814) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease acting on modified factor LiaD" /protein_id="NP_391896.2" /db_xref="EnsemblGenomes-Gn:BSU40160" /db_xref="EnsemblGenomes-Tr:CAB16053" /db_xref="GOA:Q45594" /db_xref="SubtiList:BG11481" /db_xref="UniProtKB/Swiss-Prot:Q45594" /translation="MKILKYEDEKYEVLVQNNVFIKDKKSGEYYKNSLNSLSDKQLLR FKMYKEKVSPKFFYLFLSFTALMFILNYIHLIKLQNGLSSVFYGWKMWIIIVIYFIMN IVLHELGHIYSLKFFGKNFDKVGFKLNFYVFPAFYVQLNETYMLSRNEKIIVHLFGLF INYLLINTLELINQFTFSSEALTMAFMLFSSTLLWNLIPILNSDGYKILLAFLSLDEY SRFKTNHWLVLTIQIIGIGLAVNSVVHWILYIVN*" /label="liaK CDS" gene complement(3575056..3575814) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /label="liaK gene" promotor_-10 complement(3575504..3575523) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3575520) /Source="Nicolas_upshifts" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3575536..3575543) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3575795..3576754) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /EC_number="5.1.1.-" /experiment="publication(s) with functional evidences, PMID:17921301, 18307109, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17921301, 18307109, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="AdoMet radical amino acid epimerase modifying factor LiaD" /protein_id="NP_391897.1" /db_xref="EnsemblGenomes-Gn:BSU40170" /db_xref="EnsemblGenomes-Tr:CAB16054" /db_xref="GOA:Q45595" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR023904" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG11480" /db_xref="UniProtKB/Swiss-Prot:Q45595" /translation="MYNKTVSINLDSRCNASCDHCCFSSSPTSTTRMEKEYIRELVTE FAKNKTIQVISFTGGEVFLDYKFLKELMEIIKPYEKQITLISNGFWGLSKKKVQEYFH DMNSLNVIALTISYDEYHAPFVKSSSIKNILEHSRKYPDIDISLNMAVTKDKMSNHIL EELGDSILGVKITKFPMISVGAAKTRIKQENIHKFYSLEDEDSLHCPGYDIVYHHDGE IYPCCSPAIFETKITLREEYNQSFERTVEKLNSNLLLFILRKEGFKWFLNILKENNKI EEFDIPYEFSSICGVCGSLFNSAEKINYFYPYMEKYYNENFKV*" /label="liaE CDS" gene complement(3575795..3576754) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /label="liaE gene" downshifts 3576743 /Source="Nicolas_upshifts" /id="D2078" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.40583" /MaxDrop="2.5017" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3576790..3576793 /Source="Nicolas_upshift_promotors" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3576798 /Source="Nicolas_upshifts" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3576812..3576961) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 17921301, 28644475; Product type r: regulator" /codon_start=1 /transl_table=11 /product="precursor of exported modified peptide (epipeptide) controlling LiaRS activity" /protein_id="NP_391898.1" /db_xref="EnsemblGenomes-Gn:BSU40180" /db_xref="EnsemblGenomes-Tr:CAB16055" /db_xref="InterPro:IPR023898" /db_xref="SubtiList:BG11479" /db_xref="UniProtKB/Swiss-Prot:Q45596" /translation="MKKEITNNETVKNLEFKGLLDESQKLAKVNDLWYFVKSKENRWI LGSGH*" /label="liaD CDS" gene complement(3576812..3576961) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /label="liaD gene" downshifts complement(3576819) /Source="Nicolas_upshifts" /id="D2079" /incds=0 /nref=99 /ntot=172 /MaxReadThrough="7.62324" /MaxDrop="6.01674" /score="7.49162587" /energy="-10.5" /TU="U3163" /idTUdmin="U3167" /TUdmin=2794 /isTUend="FALSE" /label="downshifts" misc_feature 3576870..3576887 /Source="Nicolas_upshift_promotors" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3576875 /Source="Nicolas_upshifts" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3576956 /Source="Nicolas_upshifts" /id="D2080" /incds=0 /nref=99 /ntot=170 /MaxReadThrough="2.55247" /MaxDrop="5.95806" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3576982..3577001) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3577003) /Source="Nicolas_upshifts" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3577016..3577023) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3577296..3577303 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3577318..3577337 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3577322 /Source="Nicolas_upshifts" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="upshifts" CDS 3577433..3579358 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /EC_number="3.1.3.11" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:221467, 9696785, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 221467, 9696785, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphatase" /protein_id="NP_391899.2" /db_xref="EnsemblGenomes-Gn:BSU40190" /db_xref="EnsemblGenomes-Tr:CAB16056" /db_xref="GOA:Q45597" /db_xref="InterPro:IPR009164" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11478" /db_xref="UniProtKB/Swiss-Prot:Q45597" /translation="MESKYLDLLAQKYDCEEKVVTEIINLKAILNLPKGTEHFVSDLH GEYQAFQHVLRNGSGRVKEKIRDIFSGVIYDREIDELAALVYYPEDKLKLIKHDFDAK EALNEWYKETIHRMIKLVSYCSSKYTRSKLRKALPAQFAYITEELLYKTEQAGNKEQY YSEIIDQIIELGQADKLITGLAYSVQRLVVDHLHVVGDIYDRGPQPDRIMEELINYHS VDIQWGNHDVLWIGAYSGSKVCLANIIRICARYDNLDIIEDVYGINLRPLLNLAEKYY DDNPAFRPKADENRPEDEIKQITKIHQAIAMIQFKLESPIIKRRPNFNMEERLLLEKI DYDKNEITLNGKTYQLENTCFATINPEQPDQLLEEEAEVIDKLLFSVQHSEKLGRHMN FMMKKGSLYLKYNGNLLIHGCIPVDENGNMETMMIEDKPYAGRELLDVFERFLREAFA HPEETDDLATDMAWYLWTGEYSSLFGKRAMTTFERYFIKEKETHKEKKNPYYYLREDE ATCRNILAEFGLNPDHGHIINGHTPVKEIEGEDPIKANGKMIVIDGGFSKAYQSTTGI AGYTLLYNSYGMQLVAHKHFNSKAEVLSTGTDVLTVKRLVDKELERKKVKETNVGEEL LQEVAILESLREYRYMK*" /label="fbp CDS" gene 3577433..3579358 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /label="fbp gene" S_feature 3579359..3580723 /Source="Nicolas_S_feature" /locus_tag="new_4130045_4131409" /HighExp="Lbstat, dia5, C30, Gly, Etha, dia15, C90, Fru, G135, Mal" /AntisenseName="yydD" /AntisenseCor="0.44422072328838003" /AntisenseRegPval="-13.7" /CDS_PredictionProba="0.22050400000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1544" S_feature complement(3579571..3579891) /Source="Nicolas_S_feature" /locus_tag="new_4130257_4130577_c" /HighExp="Cold, C30, M/G, S8, Fru, nit, Glu, BMM, Heat, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1545" CDS complement(3579892..3581652) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative DNA wielding protein" /protein_id="NP_391900.1" /db_xref="EnsemblGenomes-Gn:BSU40200" /db_xref="EnsemblGenomes-Tr:CAB16057" /db_xref="InterPro:IPR018760" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11477" /db_xref="UniProtKB/Swiss-Prot:Q45598" /translation="MIVMIIKNLFVCNSQEILKEYKFNAVGVNIILGEKREDHEETNG VGKSTMIECISFLLGKTISNFYTTNEILLNKNVFIVLNVEIDGNQVFLARSFNSPKHG YTLHDTSLTFNLEEWKKVSISVYKKFIEKEILKGEKEDITFAALREYIIRDEKTGFND IVLPNRGGLKQYKLLNYLFTLPTHTEKNIKVFRDKIEKLNSEIKLIESMNINIGDLKV KEDELINEIEDYNRVIYQTKTANKYNNDTNRYSEIKSELNKIQNEIFENEHICKQYQR NIDDLNKKVTKIKELENIEKFYEDIVGFFPEEVKQNYNKVQEFYNFMVESRGSYFKDK IVKIQADLKKLNIKKQGLTEQLESSARILKSNNFIEDISIVMEEQRRKEIELAEVRLR ISDYDKKNHIFDKINELQHEILRVNSMYYDEFQSYSAIVSELKKLFNNLMDVTYNQHG FLDFEYDNRISNAKQSTTGRIKISCSIPDERSHGRLHMKINIFDLTWFLYRCINKCSL NILIHDGSYSNPDPHVKGTLLKHINSSLLENRIGQYFVTINKNELLLDDLQELESKGM IVAKLDRNNEDKNRFFGFRF*" /label="yydD CDS" gene complement(3579892..3581652) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /label="yydD gene" downshifts complement(3579935) /Source="Nicolas_upshifts" /id="D2081" /incds=0 /nref=11 /ntot=199 /MaxReadThrough="4.99391" /MaxDrop="4.47843" /score="7.49162587" /energy="-10.5" /TU="U3167" /idTUdmin="U3167" /TUdmin="-322" /isTUend="FALSE" /label="downshifts" misc_feature 3580720..3580721 /Source="Nicolas_upshift_promotors" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3580725 /Source="Nicolas_upshifts" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3581652..3582050) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391901.1" /db_xref="EnsemblGenomes-Gn:BSU40210" /db_xref="EnsemblGenomes-Tr:CAB16058" /db_xref="SubtiList:BG11476" /db_xref="UniProtKB/Swiss-Prot:Q45599" /translation="MIDLKIETAENILKYSYVLLENEFKNIQIGNDLIPLVNNSPLKK EKAERPEMNHFLLTKYNAVEENILYSSKILYELLEKEKHIDQLFLDYAKSQGIIINLN IERILYLSLTFLYSLGKVSFNQNMISRTES*" /label="yydC CDS" gene complement(3581652..3582050) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /label="yydC gene" CDS complement(3582043..3583488) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphohydrolase" /protein_id="NP_391902.1" /db_xref="EnsemblGenomes-Gn:BSU40220" /db_xref="EnsemblGenomes-Tr:CAB16059" /db_xref="GOA:Q45600" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11475" /db_xref="UniProtKB/Swiss-Prot:Q45600" /translation="MKVRFLQISDLHFQFQNYDTIVMRDKLLDFIEVLRRESDFDFLL LTGDIAHKGDVYNEDVKEYLNGIIKSMGLSKNNVHLVPGNHDISRDMTRTLLIDSIMK SPNPSEMLDKLDQKATNILVEGQRKFFDFYEDFMGVKYPEEDLHFLYQSEKYNVLSIN TCLLSDKKGEEGTLLTAQMKLYKAIRKMNKEKNKGKVLNIAIGHHTLGCIESSERESI KAHFDDYFIDLYLAGHVHDSSFNITANTNENPFLELVSGAIIKDEYATPEFISVDVNL DNGETEVTYYIWNTEYKYWSKNNQGGRRLQEGKLNYKINRLESLIEKEIEDNDDKIDE DEFKSFIIDFHEYRESYKTFTSNFDNQIGLDKKFYDMKSGETFKRKFDSYSEYFGVIN HIMDSTSYVSADKKELIAETIVDKYLEFHNQYNNGDEIFVKIVNEIYLECHSVLPYSK ALTKKYIKILTCWCIYECEIFNDNKRSVKND*" /label="yydB CDS" gene complement(3582043..3583488) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /label="yydB gene" promotor_-35 3582738..3582745 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3582757..3582776 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3582767..3583816 /Source="Nicolas_S_feature" /locus_tag="new_4133453_4134502" /HighExp="C30, Salt, Gly, S8, Etha, LPhT, T0.30H, Heat, C90, M9-stat" /AntisenseName="yydB" /AntisenseCor="0.36202116146901597" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.431" /TUlongSig="NA" /TUlongPSig="NA" /label="S1546" upshifts 3582767 /Source="Nicolas_upshifts" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3583489..3583749) /Source="Nicolas_S_feature" /locus_tag="new_4134175_4134435_c" /HighExp="Cold, M0t90, Lbtran, M40t90, Lbstat, T0.30H, MG 150, M40t45, Gly, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1547" CDS complement(3583750..3584229) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /EC_number="2.1.1.177" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18755835, 20817755, 22411911, 22720735, 28428565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (pseudouridine1915-N3)-methyltransferase" /protein_id="NP_391903.1" /db_xref="EnsemblGenomes-Gn:BSU40230" /db_xref="EnsemblGenomes-Tr:CAB16060" /db_xref="GOA:Q45601" /db_xref="InterPro:IPR003742" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1TO0" /db_xref="SubtiList:BG11474" /db_xref="UniProtKB/Swiss-Prot:Q45601" /translation="MNINIVTIGKLKEKYLKQGIEEYTKRLSAYAKIDIIELPDEKAP ENLSDQDMKIIKDKEGDRILSKISPDAHVIALAIEGKMKTSEELADTIDKLATYGKSK VTFVIGGSLGLSDTVMKRADEKLSFSKMTFPHQLMRLILVEQIYRAFRINRGEPYHK* " /label="rlmH CDS" gene complement(3583750..3584229) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /label="rlmH gene" S_feature complement(3584230..3584309) /Source="Nicolas_S_feature" /locus_tag="new_4134916_4134995_c" /HighExp="dia5, LBGtran, T0.30H, Diami, Cold, M0t90, dia0, M0t45, M40t45, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1548" CDS complement(3584310..3584480) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097800.1" /db_xref="EnsemblGenomes-Gn:BSU40239" /db_xref="EnsemblGenomes-Tr:CAX52715" /db_xref="InterPro:IPR025626" /db_xref="UniProtKB/Swiss-Prot:C0H3T9" /translation="MKQAYYSCEEHIETVLDMYIDDHELPPEIRKIEHTNSLSTACEL CGDPAVYIVGNE*" /label="yyzF CDS" gene complement(3584310..3584480) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /label="yyzF gene" promotor_-10 complement(3584521..3584540) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3584537) /Source="Nicolas_upshifts" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3584554..3584559) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3584603..3584610 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3584623..3584642 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3584640 /Source="Nicolas_upshifts" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="upshifts" CDS 3584665..3585078 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21911367; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391904.1" /db_xref="EnsemblGenomes-Gn:BSU40240" /db_xref="EnsemblGenomes-Tr:CAB16061" /db_xref="SubtiList:BG11472" /db_xref="UniProtKB/Swiss-Prot:Q45603" /translation="MRFRWVWLFVIMLLLAECQPSYWVLEKDRIGEGSPDLEIYANYL QMHDDVKGYQVFTISEGKKMVVVSLGSSEKDKKLEVSDVKFSSKETIVTVERKPAPTA NEKNPFILIGLDKIEGDLIVQDETGDRFEETDYQQ*" /label="yycS CDS" gene 3584665..3585078 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /label="yycS gene" downshifts 3585058 /Source="Nicolas_upshifts" /id="D2082" /incds=0 /nref=17 /ntot=131 /MaxReadThrough="1.50241" /MaxDrop="5.73792" /score="16.0382598" /energy="-10.8" /TU="NA" /idTUdmin="U3168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3585112..3586338) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18820069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_391905.1" /db_xref="EnsemblGenomes-Gn:BSU40250" /db_xref="EnsemblGenomes-Tr:CAB16062" /db_xref="GOA:Q45604" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014184" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11471" /db_xref="UniProtKB/Swiss-Prot:Q45604" /translation="MGGMALTGNKAVVYKGKGTVAVEDIGYPELILRDGPGVPKANVN RKCEHGVILKVITTNICGSDQHMVRGRTTAPEGLVLGHEITGEVIETGRDVEFIKKGD IVSVPFNIACGRCVMCKTQKTHVCLNVNPDRPGSAYGYVDMGGWVGGQSEYVMVPYAD FQLLVFPDKEQALEKILDLTMLSDIFPTGFHGAYTAGVQTGSTVYIAGAGPVGLAAAH SAQLLGASTVIVGDLNEDRLAQARSFGCETVNVQKHDRLGEQIEQILGEPTVDAAVDC VGFEASGHGNQGEAPAAVLNSIMDVTQVGGSLGIPGLYVTEDPGAKDADAKTGSLKIR FGLGWAKAHTFVTGQTPAMTYNRNLMKAILSGRAQIAKAVNATVISLDDAPKGYSDFD KGAAKKFVIDPHGTLK*" /label="yycR CDS" gene complement(3585112..3586338) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /label="yycR gene" downshifts complement(3585127) /Source="Nicolas_upshifts" /id="D2083" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="0.14321" /MaxDrop="4.77892" /score="8.82768619" /energy="-6.2" /TU="NA" /idTUdmin="U3169" /TUdmin=7 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3586361..3586379) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3586366) /Source="Nicolas_upshifts" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3586391..3586399) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3586401..3586571) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097801.1" /db_xref="EnsemblGenomes-Gn:BSU40259" /db_xref="EnsemblGenomes-Tr:CAX52716" /db_xref="GOA:C0H3U0" /db_xref="UniProtKB/Swiss-Prot:C0H3U0" /translation="MQTNRVILLAVMICLVSAITVFLLNGCKVDFLDIGGTIIGCFLG IFVVVRIQKKQS*" /label="yyzG CDS" gene complement(3586401..3586571) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /label="yyzG gene" promotor_-10 complement(3586590..3586608) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3586608) /Source="Nicolas_upshifts" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3586622..3586628) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3586676..3586924) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391906.1" /db_xref="EnsemblGenomes-Gn:BSU40260" /db_xref="EnsemblGenomes-Tr:CAB16063" /db_xref="GOA:Q45605" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG11470" /db_xref="UniProtKB/Swiss-Prot:Q45605" /translation="MGAIAVLFIVFGFPIVAGVFGIAGHFLFKRFWVAPLIVLITSLI LLVTLASGNSSFIFWVVMYTAIALVTSVATLFLRKFFE*" /label="yycQ CDS" gene complement(3586676..3586924) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /label="yycQ gene" CDS complement(3586940..3588103) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812, 16291680" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391907.2" /db_xref="EnsemblGenomes-Gn:BSU40270" /db_xref="EnsemblGenomes-Tr:CAB16064" /db_xref="InterPro:IPR011047" /db_xref="SubtiList:BG11469" /db_xref="UniProtKB/Swiss-Prot:Q45606" /translation="MKKWMITIAMLILAGIALFVFISPLKSHKTVSQQDLRNPDFLDD KEVLLYFSSSADQDAFGGGKSYALFISHDGTLSSFQMKGLELGSAKVHGDSVMLEDKN TIYTIKNGLRSHKRTYQHTGDSAGFLQNTDGFYTLYNSGYDKKGDGYRSELYRQMDGE WKKDVIPYYIRASGFHDGAIYALVPTDDGKGYQLLQIQADQKKLTYLSITEWQYREGA SVESQLAVDDQAVYVMVRGQKAHDLYQMVKINKKSGEVELHDIAEYKNDEQTIYSSMP FSFKNSFFPYDGNLYFIDGFGKVHKIDAKTGKTSIVFTLSPDKMKAEFKEITQKGSSL YFFTYTYHKPAYIEQYSLKTGKKMKEKEIGKVKDVVTPKSHLKLYDVEVMKRF*" /label="yycP CDS" gene complement(3586940..3588103) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /label="yycP gene" promotor_-10 complement(3586974..3586992) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3586982) /Source="Nicolas_upshifts" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3587004..3587012) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3588114..3588851) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_391908.1" /db_xref="EnsemblGenomes-Gn:BSU40280" /db_xref="EnsemblGenomes-Tr:CAB16065" /db_xref="SubtiList:BG11468" /db_xref="UniProtKB/Swiss-Prot:Q45607" /translation="MKLKKRVSMFLVALTMCGGLFVTPAKAVKTTNYAEEIAALQPGT TPEEIMKSASQIAKQQHVKQDVILKQFYKEITADKAEGDRLAKESGMSIMGGSSGTKK LPTSAKGNIYYTNSYTAYYNHGHVGMYSAADKIVESVPSDGVRQIAYNARDVEDNSIV QTVSVSSSQKTAAADWAVSKVGDPYSFNFVNNRNTGHDGAKNCSKLLWSAFLLKAGID IDSNGGLGVYPRDITSSSYTTTIMTIY*" /label="yycO CDS" gene complement(3588114..3588851) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /label="yycO gene" promotor_-10 complement(3588893..3588911) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3588899) /Source="Nicolas_upshifts" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3588925..3588933) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3588993..3589463) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14635137, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391909.1" /db_xref="EnsemblGenomes-Gn:BSU40290" /db_xref="EnsemblGenomes-Tr:CAB16066" /db_xref="GOA:O32293" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1ON0" /db_xref="PDB:1UFH" /db_xref="SubtiList:BG11467" /db_xref="UniProtKB/Swiss-Prot:O32293" /translation="MTIMLTPMQTEEFRSYLTYTTKHYAEEKVKAGTWLPEDAQLLSK QVFTDLLPRGLETPHHHLWSLKLNEKDIVGWLWIHAEPEHPQQEAFIYDFGLYEPYRG KGYAKQALAALDQAARSMGIRKLSLHVFAHNQTARKLYEQTGFQETDVVMSKKL*" /label="yycN CDS" gene complement(3588993..3589463) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /label="yycN gene" downshifts complement(3589006) /Source="Nicolas_upshifts" /id="D2084" /incds=0 /nref=1 /ntot=78 /MaxReadThrough="3.78599" /MaxDrop="2.94893" /score="8.04802973" /energy="-7.6" /TU="U3175" /idTUdmin="U3174" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3589464..3589534) /Source="Nicolas_S_feature" /locus_tag="new_4140150_4140220_c" /HighExp="S4, S5, S6, LoTm, S3, S7, S8, B36, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1549" promotor_-35 3589495..3589501 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3589515..3589534 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3589516..3589535) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3589516 /Source="Nicolas_upshifts" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3589534) /Source="Nicolas_upshifts" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3589536..3589811) /Source="Nicolas_S_feature" /locus_tag="new_4140222_4140497_c" /HighExp="S4, S5, S6, S7, S8, S3, B36, BT, LoTm, T5.0H" /AntisenseName="rapG" /AntisenseCor="-0.20647217228472101" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1550" promotor_-35 complement(3589550..3589557) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3589574..3590671 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391910.1" /db_xref="EnsemblGenomes-Gn:BSU40300" /db_xref="EnsemblGenomes-Tr:CAB16067" /db_xref="GOA:O32294" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11466" /db_xref="UniProtKB/Swiss-Prot:O32294" /translation="MNKIAPAEIASMLNDWYLAIKKHEVEESSRLFEEVKPLLDDMEE DQEVLAYFSLLELRHKVLLHEARGQGFQHEEPSHMNATSDMLKYYFFLFEGMYEAYKN NYDIAIGLYKDAEQYLDNIPDPIEKAEFHLKVGKLYYKLGQNIVSLNHTRQAVKTFRE ETDYKKKLASALITMSGNFTEMSQFEEAEAYLDEAIRITSELEDHFFEAQLLHNFGLL HAQSGKSEEAVSKLEEALQNDEYARSAYYYHSAYLLIRELFKIKKKEQALSYYQDVKE KLTAEPNRICEAKIDILYAIYAEGGHAETFHLCKQHMDDLLSEKEYDSVRELSILAGE RYRELELYKEAAHFFYEALQIEELIKRTEVI*" /label="rapG CDS" gene 3589574..3590671 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /label="rapG gene" promotor_-10 complement(3589802..3589820) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-10" upshifts complement(3589811) /Source="Nicolas_upshifts" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="upshifts" promotor_-35 complement(3589835..3589840) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-35" promotor_-35 3590395..3590403 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3590415..3590433 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3590428 /Source="Nicolas_upshifts" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="upshifts" CDS 3590672..3590788 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878, 16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878, 16816200; Product type r: regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapG" /protein_id="NP_391911.1" /db_xref="EnsemblGenomes-Gn:BSU40310" /db_xref="EnsemblGenomes-Tr:CAB16068" /db_xref="InterPro:IPR030968" /db_xref="SubtiList:BG11465" /db_xref="UniProtKB/Swiss-Prot:O32295" /translation="MKRFLIGAGVAAVILSGWFIADHQTHSQEMKVAEKMIG*" /label="phrG CDS" gene 3590672..3590788 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /label="phrG gene" downshifts 3590777 /Source="Nicolas_upshifts" /id="D2085" /incds=0 /nref=39 /ntot=249 /MaxReadThrough="4.8963" /MaxDrop="7.30713" /score="31.0184314" /energy="-13.7" /TU="U3173,U3176" /idTUdmin="U3173" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3591025..3591915) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /EC_number="3.5.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginase" /protein_id="NP_391912.1" /db_xref="EnsemblGenomes-Gn:BSU40320" /db_xref="EnsemblGenomes-Tr:CAB16069" /db_xref="GOA:P39138" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR014033" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG10932" /db_xref="UniProtKB/Swiss-Prot:P39138" /translation="MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTV EDLGDIPINREKIKNDEELKNLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIG TLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEGYAP KIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSACDGV HLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHK NKTGKTAVELVESLLGKKLL*" /label="argI CDS" gene complement(3591025..3591915) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /label="argI gene" downshifts complement(3591031) /Source="Nicolas_upshifts" /id="D2086" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.33097" /MaxDrop="3.38667" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" downshifts complement(3591093) /Source="Nicolas_upshifts" /id="D2087" /incds=1 /nref=28 /ntot=201 /MaxReadThrough="5.16507" /MaxDrop="5.79932" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-151" /isTUend="FALSE" /label="downshifts" CDS complement(3591989..3593392) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7540694, 10648515, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 10648515, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arginine/ornithine/gamma-aminobutyrate permease" /protein_id="NP_391913.1" /db_xref="EnsemblGenomes-Gn:BSU40330" /db_xref="EnsemblGenomes-Tr:CAB16070" /db_xref="GOA:P39137" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10933" /db_xref="UniProtKB/Swiss-Prot:P39137" /translation="MNTNQDNGNQLQRTMKSRHLFMISLGGVIGTGFFLGTGFTINQA GPLGAVLSYLVGGFIMFLTMLCLGELAVAFPVSGSFQTYATKFISPAFGFAFGWLYWL GWAVTCAIEFLSAGQLMQRWFPHIDVWIWCLVFAALMFILNAITTKAFAESEFWFSGI KILIILLFIILGGAAMFGLIDLKGGEQAPFLTHFYEDGLFPNGIKAMLITMITVNFAF QGTELIGVAAGESEDPEKTIPRSIKQTVWRTLVFFVLSIIVIAGMIPWKQAGVVESPF VAVFEQIGIPYAADIMNFVILIALLSVANSGLYASTRILYAMANEGQAFKALGKTNQR GVPMYSLIVTMAVACLSLLTKFAQAETVYMVLLSLAGMSAQVGWITISLSQIMFRRKY IREGGKIEDLKFKTPLYPVLPLIGLTLNTVVLISLAFDPEQRIALYCGVPFMIICYII YHVVIKKRQQANRQLEL*" /label="rocE CDS" gene complement(3591989..3593392) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /label="rocE gene" S_feature complement(3593393..3593614) /Source="Nicolas_S_feature" /locus_tag="new_4144079_4144300_c" /HighExp="Lbstat, S0, LPh, T1.30H, HPh, T2.0H, LPhT, BI, M0t90, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.884" /TUlongSig="NA" /TUlongPSig="NA" /label="S1551" CDS complement(3593615..3594820) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /EC_number="2.6.1.13" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7540694, 9383188, 22720735, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 9383188, 22720735, 23869754; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine aminotransferase" /protein_id="NP_391914.1" /db_xref="EnsemblGenomes-Gn:BSU40340" /db_xref="EnsemblGenomes-Tr:CAB16071" /db_xref="GOA:P38021" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR010164" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR034757" /db_xref="SubtiList:BG10722" /db_xref="UniProtKB/Swiss-Prot:P38021" /translation="MTALSKSKEIIDQTSHYGANNYHPLPIVISEALGAWVKDPEGNE YMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSRAFHNDQLGPFYEKTAKLTGKEM ILPMNTGAEAVESAVKAARRWAYEVKGVADNQAEIIACVGNFHGRTMLAVSLSSEEEY KRGFGPMLPGIKLIPYGDVEALRQAITPNTAAFLFEPIQGEAGIVIPPEGFLQEAAAI CKEENVLFIADEIQTGLGRTGKTFACDWDGIVPDMYILGKALGGGVFPISCIAADREI LGVFNPGSHGSTFGGNPLACAVSIASLEVLEDEKLADRSLELGEYFKSELESIDSPVI KEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHDTVIRFAPPLIISKEDLDWAIE KIKHVLRNA*" /label="rocD CDS" gene complement(3593615..3594820) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /label="rocD gene" misc_feature complement(3594877..3594895) /Source="Nicolas_upshift_promotors" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3594880) /Source="Nicolas_upshifts" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3594990..3594995 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3595010..3595029 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3595025 /Source="Nicolas_upshifts" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="upshifts" CDS 3595061..3596446 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9194709, 12533460, 12634342, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9194709, 12533460, 12634342, 23869754; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NtrC/NifA family)" /protein_id="NP_391915.1" /db_xref="EnsemblGenomes-Gn:BSU40350" /db_xref="EnsemblGenomes-Tr:CAB16072" /db_xref="GOA:P38022" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG10723" /db_xref="UniProtKB/Swiss-Prot:P38022" /translation="MVKDSEFLTLVFQSILDEIDVGLHVVDEHGNTIVYNNKMMQIED MEKHDVLNKNLMDVFMFSKQQDSTLVQALQEGKTIKNVKQSYFNNKGQEITTINHTYP IVQDGKIRGAVEIAKDVTKLERLIRENMNKKGSTTYTFDSILGTSPAIQDVIENAKRA TRTSSSVLLAGETGTGKELFAQSIHNGSDRSGGPFISQNCAALPDSLVESILFGTKKG AFTGAVDQPGLFEQAHGGTLLLDEINSLNLSLQAKLLRALQERKIRRIGSTKDTPIDV RIIATMNEDPIDAIAGERMRKDLYYRLSVVTLIIPPLRERKEDILLLASEFIQKNNHL FQMNVEHISDDVKQFFLSYDWPGNIRELEHMIEGAMNFMTDEQTITASHLPYQYRMKI KPADIPEPETPRHQPAADLKEKMESFEKYVIENVLRKHGHNISKAAQELGISRQSLQY RLKKFSHSSNE*" /label="rocR CDS" gene 3595061..3596446 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /label="rocR gene" CDS complement(3596428..3596616) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17198402; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative sensor protein" /db_xref="PSEUDO:CAX52717.1" /translation="MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIG RGTVFLIRLPAPDYSLDE*" /label="yyzO CDS" gene complement(3596428..3596616) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /pseudo /label="yyzO gene" CDS complement(3596733..3596861) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514013.1" /translation="MPGCFDMQKKLNRGHARSVEKGYIEYEEKYKMDVTRETANGS*" /label="hypothetical protein CDS" gene complement(3596733..3596861) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /label="gene" downshifts 3596785 /Source="Nicolas_upshifts" /id="D2088" /incds=0 /nref=1 /ntot=146 /MaxReadThrough="0.86899" /MaxDrop="2.90385" /score="20.2816165" /energy="-10.8" /TU="NA" /idTUdmin="U3178" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS complement(3596881..3598083) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /EC_number="3.4.21.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 16030236, 25384476" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 16030236, 25384476; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation membrane serine protease" /protein_id="NP_391916.1" /db_xref="EnsemblGenomes-Gn:BSU40360" /db_xref="EnsemblGenomes-Tr:CAB16073" /db_xref="GOA:P39668" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG11054" /db_xref="UniProtKB/Swiss-Prot:P39668" /translation="MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPY LSNEGLDTGALDQQQNNNGRESIRTVNVSVNNAVTKIVSNMSPAVVGVVNIQKSDIWG ESGEAGSGSGVIYKKNDHSAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDL AVLRVKSDKIKAVADFGNSDKVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVD SNGDGQPDWNAEVLQTDAAINPGNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPS KLVIPVIEDLERYGKVKRPFLGIEMKSLSDIASYHWDETLKLPKNVTNGAVVMGVDAF SPAGKAGLKELDVITEFDGYKVNDIVDLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKL SSADQLGS*" /label="htrC CDS" gene complement(3596881..3598083) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /label="htrC gene" downshifts complement(3596905) /Source="Nicolas_upshifts" /id="D2089" /incds=0 /nref=134 /ntot=253 /MaxReadThrough="2.3073" /MaxDrop="5.06813" /score="5.6507537" /energy="-15" /TU="NA" /idTUdmin="U3179" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3598115..3598126) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3598115) /Source="Nicolas_upshifts" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3598141..3598147) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3598165..3598959) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9829949, 16030236, 21169496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391917.2" /db_xref="EnsemblGenomes-Gn:BSU40370" /db_xref="EnsemblGenomes-Tr:CAB16074" /db_xref="GOA:C0SP91" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11464" /db_xref="UniProtKB/Swiss-Prot:C0SP91" /translation="MSLQFSVLASGSTGNAFYLETEDHAFLVDAGLSGKAMDGLMAQI GRKLDDVDGIFVTHEHSDHIKGLGVVARKYKLPIYANEKTWKAMENQIGKIDTDQKFV FPMETVKSFGGLDVESFGVSHDAAEPMFYVFHYSGRKLALMTDTGYVSDRMKGIIRSA NVFVFESNHDVGMLQMGRYPWSIKRRILSDVGHVSNEDAALAMTDVIGDETSRIYLAH LSQDNNMKELARMSVQQTLASKGFVTGETFDLYDTDPKKATPLCAV*" /label="walJ CDS" gene complement(3598165..3598959) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /label="walJ gene" CDS complement(3598981..3599823) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 17307848, 17307850, 18408157, 21219466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 17307848, 17307850, 18408157, 21219466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK" /protein_id="NP_391918.1" /db_xref="EnsemblGenomes-Gn:BSU40380" /db_xref="EnsemblGenomes-Tr:CAB16075" /db_xref="GOA:Q45612" /db_xref="InterPro:IPR018604" /db_xref="PDB:2O3O" /db_xref="SubtiList:BG11463" /db_xref="UniProtKB/Swiss-Prot:Q45612" /translation="MEWNKTKSIFIVAFLILDIFLGYQFFQKWQATGKEYEVIKNDVE HDMKADHITYEGLNKEATEGYRITANQKSFSKEEIEALKDQKPLMDMPSDDHKVTSLK MKFANPIALSKKDIEDDAQALVSSKIQDGEKYKLWKVDKSKKEIIFFQTYEGHYIYQK TDNPSNMIGQVVLHLNGKNEVVSYDQTTLETFKQIQKESLITEMDAVELLYYQNQLKE YSTVKSCKFGYVAQYPLTSTQVLAPVWRITVEYEKKVNGEKKTVQEYFTVNALESTIL DTDQ*" /label="walI CDS" gene complement(3598981..3599823) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /label="walI gene" CDS complement(3599810..3601177) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 16600972, 17307850, 26999783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 16600972, 17307850, 26999783; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK(YycFG)" /protein_id="NP_391919.1" /db_xref="EnsemblGenomes-Gn:BSU40390" /db_xref="EnsemblGenomes-Tr:CAB16076" /db_xref="GOA:Q794W0" /db_xref="InterPro:IPR009996" /db_xref="PDB:2FGT" /db_xref="SubtiList:BG11462" /db_xref="UniProtKB/Swiss-Prot:Q794W0" /modified_by="User" /translation="MKRENIKTILLTVLVVISLVFTWGIWTFQPNFSEGSSSTESTVR VKHKIEKTTQKLSETVRPRDMFIHDDGAHYKVDDNALYEEIWSDLPHWDVKGIKDISD QYDKAGFKSWFYGIGGSEAKLDLQFSDTIPIDIFQTLFKWSNQSFEYSSFDHILIPFN ETKANKKIYLVSYSKQLILEVTVESANYRNIMNDLKNRQSNMPAFSLFSIGSKKEFLL PNKPLTMDKKEFVTESIKTNTFKQALFSDPSIVREDSNYTNRNVLTDGISRLDVNLSQ RQVQFQQRNLVQSTSYQTGELIKKSQKYLEDTGSWTDHYQFFNINDSQQLSFYIFMDQ IPVINSTAKPFGATSAITVQWANDDILSYKRPNYSLGTNPIKTSETELMGGSEVKMLL SKQTAYDTDKIDQIFLAYQLVSTSTNDDPLVELEPVWAMKVNGKIVPITKDLLRKEGA NSGVE*" /label="Delta6_BSU_40390_SNPvariant" gene complement(3599810..3601177) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /modified_by="User" /label="Delta6_BSU_40390_SNPvariant" Polymorphism join(3600404,3600406) /Source="geneious" /ID="SNP_BsDelta6_4151091_4151091" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="N -> T" /CDS_Position=773 /Change="T -> G" /Codon_Change="AAC -> ACC" /Coverage=184 /locus_tag="BSU_40390" /Protein_Effect="Substitution" /Reference_Frequency="0.5%" /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="Delta6_BSU_40390_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(3601167..3603002) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YycG]" /protein_id="NP_391920.1" /db_xref="EnsemblGenomes-Gn:BSU40400" /db_xref="EnsemblGenomes-Tr:CAB16077" /db_xref="GOA:Q45614" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3SL2" /db_xref="SubtiList:BG11461" /db_xref="UniProtKB/Swiss-Prot:Q45614" /translation="MNKVGFFRSIQFKITLIYVLLIIIAMQIIGVYFVNQVEKSLISS YEQSLNQRIDNLSYYIEQEYKSDNDSTVIKDDVSRILNDFTKSDEVREISFVDKSYEV VGSSKPYGEEVAGKQTTDLIFKRIFSTKQSYLRKYYDPKSKIRVLISAKPVMTENQEV VGAIYVVASMEDVFNQMKTINTILASGTGLALVLTALLGIFLARTITHPLSDMRKQAM ELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQAMTEGERRKLASVIAYMTDGV IATNRNGAIILLNSPALELLNVSRETALEMPITSLLGLQENYTFEDLVEQQDSMLLEI ERDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPL TTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNRE WIQIVRFMSLIIDRFEMTKEQHVEFIRNLPDRDLYVEIDQDKITQVLDNIISNALKYS PEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGL GLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDDWDEA*" /label="walK CDS" gene complement(3601167..3603002) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /label="walK gene" CDS complement(3603010..3603717) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YycF]" /protein_id="NP_391921.1" /db_xref="EnsemblGenomes-Gn:BSU40410" /db_xref="EnsemblGenomes-Tr:CAB16078" /db_xref="GOA:P37478" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2D1V" /db_xref="PDB:2ZWM" /db_xref="PDB:3F6P" /db_xref="SubtiList:BG10001" /db_xref="UniProtKB/Swiss-Prot:P37478" /translation="MDKKILVVDDEKPIADILEFNLRKEGYEVHCAHDGNEAVEMVEE LQPDLILLDIMLPNKDGVEVCREVRKKYDMPIIMLTAKDSEIDKVIGLEIGADDYVTK PFSTRELLARVKANLRRQLTTAPAEEEPSSNEIHIGSLVIFPDAYVVSKRDETIELTH REFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPNW IVTRRGVGYYLRNPEQD*" /label="walR CDS" gene complement(3603010..3603717) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /label="walR gene" S_feature complement(3603718..3603814) /Source="Nicolas_S_feature" /locus_tag="new_4154404_4154500_c" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, dia0, LBGstat, dia5, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="1, 1, 0.11" /TUlongSig="SigA" /TUlongPSig="0.986" /label="S1552" promotor_-10 complement(3603802..3603821) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3603814) /Source="Nicolas_upshifts" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3603816..3604008) /Source="Nicolas_S_feature" /locus_tag="new_4154502_4154694_c" /HighExp="G180, Paraq, Oxctl, G135, G150, H2O2, T0.30H, BMM, Cold, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="0.986, 1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1553" promotor_-35 complement(3603837..3603840) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3604008) /Source="Nicolas_upshifts" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="upshifts" misc_feature complement(3604018..3604037) /Source="Nicolas_upshift_promotors" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3604100) /Source="Nicolas_upshifts" /id="D2090" /incds=0 /nref=8 /ntot=83 /MaxReadThrough="5.21091" /MaxDrop="5.81799" /score="24.1725164" /energy="-10.6" /TU="U3183,U3184" /idTUdmin="U3181" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" tRNA complement(3604101..3604173) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Phe tRNA" gene complement(3604101..3604173) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /label="trnY-Phe gene" tRNA complement(3604209..3604285) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Asp tRNA" gene complement(3604209..3604285) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /label="trnY-Asp gene" S_feature complement(3604286..3604366) /Source="Nicolas_S_feature" /locus_tag="new_4154972_4155052_c" /HighExp="Oxctl, Heat, BMM, Paraq, UNK1, H2O2, C30, MG 45, G180, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1554" tRNA complement(3604367..3604438) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Glu tRNA" gene complement(3604367..3604438) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /label="trnY-Glu gene" tRNA complement(3604448..3604523) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Lys tRNA" gene complement(3604448..3604523) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /label="trnY-Lys gene" misc_feature 3604495..3604511 /Source="Nicolas_upshift_promotors" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3604508 /Source="Nicolas_upshifts" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3604524..3604620) /Source="Nicolas_S_feature" /locus_tag="new_4155210_4155306_c" /HighExp="LBGstat, C30, UNK1, Oxctl, HPh, Heat, MG 150, BMM, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1555" promotor_-10 complement(3604604..3604623) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3604620) /Source="Nicolas_upshifts" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3604637..3604644) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(3604654..3604755) /Source="Nicolas_upshift_promotors" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3604694) /Source="Nicolas_upshifts" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3604748..3606040) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /EC_number="6.3.4.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1312531, 10368157, 16163456, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1312531, 10368157, 16163456, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate synthetase" /protein_id="NP_391922.1" /db_xref="EnsemblGenomes-Gn:BSU40420" /db_xref="EnsemblGenomes-Tr:CAB16079" /db_xref="GOA:P29726" /db_xref="InterPro:IPR001114" /db_xref="InterPro:IPR018220" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033128" /db_xref="SubtiList:BG10002" /db_xref="UniProtKB/Swiss-Prot:P29726" /translation="MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGNNAGHTIK FDGITYKLHLIPSGIFYKDKTCVIGNGMVVDPKALVTELAYLHERNVSTDNLRISNRA HVILPYHLKLDEVEEERKGANKIGTTKKGIGPAYMDKAARIGIRIADLLDRDAFAEKL ERNLEEKNRLLEKMYETEGFKLEDILDEYYEYGQQIKKYVCDTSVVLNDALDEGRRVL FEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPTKIKHVVGVSKAYTTRVGDGP FPTELKDEIGDQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGITDLSLNSIDVL AGIETLKICVAYRYKGEIIEEFPASLKALAECEPVYEEMPGWTEDITGAKSLSELPEN ARHYLERVSQLTGIPLSIFSVGPDRSQTNVLRSVYRAN*" /label="purA CDS" gene complement(3604748..3606040) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /label="purA gene" downshifts complement(3604759) /Source="Nicolas_upshifts" /id="D2091" /incds=0 /nref=200 /ntot=241 /MaxReadThrough="2.03104" /MaxDrop="6.53551" /score="13.9967927" /energy="-10.5" /TU="NA" /idTUdmin="U3185" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3606080..3606099) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3606100) /Source="Nicolas_upshifts" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3606114..3606121) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3606246..3606665) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16731985" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391923.1" /db_xref="EnsemblGenomes-Gn:BSU40430" /db_xref="EnsemblGenomes-Tr:CAB16080" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:1TWU" /db_xref="SubtiList:BG10003" /db_xref="UniProtKB/Swiss-Prot:P37479" /translation="MGKRFSSFQAAQIRIARPTGQLDEIIRFYEEGLCLKRIGEFSQH NGYDGVMFGLPHADYHLEFTQYEGGSTAPVPHPDSLLVFYVPNAVELAAITSKLKHMG YQEVESENPYWSNGGVTIEDPDGWRIVFMNSKGISGK*" /label="yycE CDS" gene complement(3606246..3606665) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /label="yycE gene" promotor_-10 complement(3606663..3606674) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3606674) /Source="Nicolas_upshifts" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3606689..3606695) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3606786..3608150) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /EC_number="3.6.4.12" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="replicative DNA helicase" /protein_id="NP_391924.2" /db_xref="EnsemblGenomes-Gn:BSU40440" /db_xref="EnsemblGenomes-Tr:CAB16081" /db_xref="GOA:P37469" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR007692" /db_xref="InterPro:IPR007693" /db_xref="InterPro:IPR007694" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036185" /db_xref="SubtiList:BG10004" /db_xref="UniProtKB/Swiss-Prot:P37469" /translation="MTDLLNDRLPPQNIEAEQAVLGAIFLQPSALTLASEVLIPDDFY RMSHQKIYNAMLVLGDRGEPVDLVTVTSELANTDLLEEVGGISYLTDIANSVPTAANI EYYAKIVEEKSILRRLIRTATTIAQDGYTREDEVEDLLSEAEKTIMEVAQRKNTSAFQ NIKDVLVQTYDNIEQLHNRKGDITGIPTGFTELDRMTAGFQRNDLIIVAARPSVGKTA FALNIAQNVATKTDESVAIFSLEMGAEQLVMRMLCAEGNINAQNLRTGNLTEEDWGKL TMAMGSLSNSGIYIDDTPGIRVSEIRAKCRRLKQESGLGMILIDYLQLIQGSGRSKDN RQQEVSEISRELKSIARELQVPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADI VAFLYRDDYYDKETENKNIIEIIIAKQRNGPVGTVSLAFVKEYNKFVNLERRFDDAGV PPGA*" /label="dnaC CDS" gene complement(3606786..3608150) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /label="dnaC gene" downshifts complement(3606806) /Source="Nicolas_upshifts" /id="D2092" /incds=0 /nref=3 /ntot=107 /MaxReadThrough="1.37092" /MaxDrop="3.96365" /score="31.6981667" /energy="-12.6" /TU="NA" /idTUdmin="U3187" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3606850) /Source="Nicolas_upshifts" /id="D2093" /incds=1 /nref=9 /ntot=190 /MaxReadThrough="3.89737" /MaxDrop="3.21735" /score="31.6981667" /energy="-12.6" /TU="U3187" /idTUdmin="U3190" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3608181..3608200) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3608195) /Source="Nicolas_upshifts" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3608215..3608217) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3608262..3608268 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-35" promotor_-10 3608283..3608301 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-10" upshifts 3608285 /Source="Nicolas_upshifts" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="upshifts" CDS 3608320..3608520 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391925.1" /db_xref="EnsemblGenomes-Gn:BSU40450" /db_xref="EnsemblGenomes-Tr:CAB16082" /db_xref="InterPro:IPR018691" /db_xref="InterPro:IPR020086" /db_xref="SubtiList:BG10005" /db_xref="UniProtKB/Swiss-Prot:P37480" /translation="MIKKYAITPNVDADGWFIEVENVAPTALYTSKDAAIEKAKQVAK ENSPSKLVIYDQFKNVEEEHSF*" /label="yycD CDS" gene 3608320..3608520 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /label="yycD gene" downshifts 3608490 /Source="Nicolas_upshifts" /id="D2094" /incds=0 /nref=15 /ntot=43 /MaxReadThrough="4.45045" /MaxDrop="5.68737" /score="12.3008592" /energy="-9.5" /TU="U3188" /idTUdmin="U3188" /TUdmin="-352" /isTUend="FALSE" /label="downshifts" S_feature 3608535..3608856 /Source="Nicolas_S_feature" /locus_tag="new_4159220_4159541" /HighExp="Etha, C30, Salt, S6, S8, M9-stat, S7, Oxctl, Paraq, Heat" /AntisenseName="yyzB" /AntisenseCor="0.309580857935493" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1556" CDS complement(3608568..3608771) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391926.1" /db_xref="EnsemblGenomes-Gn:BSU40460" /db_xref="EnsemblGenomes-Tr:CAB16083" /db_xref="SubtiList:BG14171" /db_xref="UniProtKB/Swiss-Prot:O32296" /translation="MHAPLSLLKQMLKEHQIDTEKAVTFEEYIAMRLKLQELMGKFAS IGEWDLYQKAADLMMHIGIQWMK*" /label="yyzB CDS" gene complement(3608568..3608771) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /label="yyzB gene" S_feature complement(3608772..3609072) /Source="Nicolas_S_feature" /locus_tag="new_4159457_4159757_c" /HighExp="S6, S8, S7, S5, S4, BT, B36, T5.0H, S3, C30" /AntisenseName="yycC" /AntisenseCor="-0.77379453158709499" /AntisenseRegPval="-54.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.049" /TUlongSig="NA" /TUlongPSig="NA" /label="S1557" promotor_-35 3608837..3608840 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3608855..3608874 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3608858 /Source="Nicolas_upshifts" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="upshifts" CDS 3608892..3609032 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28546427" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391927.1" /db_xref="EnsemblGenomes-Gn:BSU40470" /db_xref="EnsemblGenomes-Tr:CAB16084" /db_xref="InterPro:IPR025550" /db_xref="SubtiList:BG10006" /db_xref="UniProtKB/Swiss-Prot:P37481" /translation="MRPLQISAETAQKLAESLNLPLEQIMHMPQHILLAKMAELQKED KS*" /label="yycC CDS" gene 3608892..3609032 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /label="yycC gene" S_feature 3609033..3609104 /Source="Nicolas_S_feature" /locus_tag="new_4159718_4159789" /HighExp="Sw, LoTm, Gly, BC, HiOs, B60, S0, T-5.40H, LBGstat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig=1 /label="S1558" upshifts complement(3609080) /Source="Nicolas_upshifts" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3609083..3609097) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3609105..3609109) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3609105..3610313 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25790494; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion ABC transporter (permease)" /protein_id="NP_391928.1" /db_xref="EnsemblGenomes-Gn:BSU40480" /db_xref="EnsemblGenomes-Tr:CAB16085" /db_xref="GOA:P37482" /db_xref="InterPro:IPR004747" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10007" /db_xref="UniProtKB/Swiss-Prot:P37482" /translation="MPHPHNKKIQSFWLITGIIFIAFNLRPAITSVGPVISSIRAELH MSNGAAGFLTALPLLSFAVLSPLAPKLGQRLGNERTLWLGLVILLIGVLTRSTGYTAA LFFGTALIGVGIAIGNVLLPSLIKHKYPEKPGIMISLYTTSMNIFAALASGVSVPLAT QMNGGWKQAFLLWGGLALLALLIWIPQLRHRDTANQTMKLQSSSIWASKMAWYVTIFM GLQSFLFYSSIAWFPEILRSHGIDTATAGWMVSLMQFASLPSTFLTPVLADRVKQQRG IVAALASVYLIGLCGLLAGGSHTLLAIWMIIIGIGQGSSISLALTLIGLRSENAQQAA ALSGMSQSFGYLLAAVGPIFVGYLFDQTHSWTMPIVLLIAALIVMGAAGQGAGRDRYI FQSEKQRNSA*" /label="yycB CDS" gene 3609105..3610313 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /label="yycB gene" downshifts 3610294 /Source="Nicolas_upshifts" /id="D2095" /incds=0 /nref=148 /ntot=242 /MaxReadThrough="3.65611" /MaxDrop="4.91246" /score="26.443484" /energy="-10.1" /TU="U3189" /idTUdmin="U3189" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 3610418..3612475 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase" /protein_id="NP_391929.2" /db_xref="EnsemblGenomes-Gn:BSU40490" /db_xref="EnsemblGenomes-Tr:CAB16086" /db_xref="GOA:P37483" /db_xref="SubtiList:BG10008" /db_xref="UniProtKB/Swiss-Prot:P37483" /translation="MKTKRFDAALILILLAAAFLNTYHIWQDDTANQYYLAAVKSMTQ SFHNFFYASFDPSGFVTVDKPPVVLWIQTIFALIFGVHTWSVIIPQALAGVGSVFLLY RMVKPTFGVGAARIAALVMALTPIAVAVSRTNNIDSMLVFTLLLGSTCLLRAVKQGKL VWLLTAFALIGLAFNMKMMQAFMVLPAFVLFYLIASRVSLKKKIGSLLLSLVLLTGLS LSWAIAVDSASSSSRPYVGSSQTNSVLELAFGYNGTERLFGQTTGLAKGDMNAAGGGN MQNQDNMQAPNGNGSSFSQNGNQSFGNHSQAPQPPNGQTGALNGGGGTPPTGGNGPGN GGPGGGGGKSVNMFGTGDPGPLRLFQSALSGQISWMLPFSLIGLLGAIISWYRDRRGH AAKMKETLFWAAWLVPVAGFFSIAGFFHQYYLIMLAPPIAALSGIGWYTMHRLYKNNK DWSSYLLPAAVLITAVFQVYILSAYTSQIGSVWMYVLGLLGLGITLALLMLKRSHPFS KLLTIISLCVLLLTPVYWSATPLLYGGNSVLPESGPQLKGSANGGNMFSSEVDSGLLS YLRKHNTGEEYLFATLTTVTAAPYIIYENESVMAMGGFNGTDPILTVSELKKLIKEGK VKYFLLSENNSGNSELVSWIKKNGKEITSDEYSGSSSSTNSVQGMRRGPGGESQQTLY LVE*" /label="yycA CDS" gene 3610418..3612475 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /label="yycA gene" downshifts 3612340 /Source="Nicolas_upshifts" /id="D2096" /incds=1 /nref=43 /ntot=203 /MaxReadThrough="1.96363" /MaxDrop="3.65354" /score="19.8733078" /energy="-16.6" /TU="NA" /idTUdmin="U3189" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(3612512..3612961) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 23002217; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L9" /protein_id="NP_391930.1" /db_xref="EnsemblGenomes-Gn:BSU40500" /db_xref="EnsemblGenomes-Tr:CAB16087" /db_xref="GOA:P37437" /db_xref="InterPro:IPR000244" /db_xref="InterPro:IPR009027" /db_xref="InterPro:IPR020069" /db_xref="InterPro:IPR020070" /db_xref="InterPro:IPR020594" /db_xref="InterPro:IPR036791" /db_xref="InterPro:IPR036935" /db_xref="SubtiList:BG10009" /db_xref="UniProtKB/Swiss-Prot:P37437" /translation="MKVIFLQDVKGKGKKGEVKNVADGYAHNFLIKKGLAVEANASNI SALNGQKQKEKKEAIAELEQAKSLKETLEKLTVELSAKSGEGGRLFGSVTSKQITEQL QKDHNIKVDKRKLELPDGIRALGYTNVPVKLHPEVQAVLKVHVKEEA*" /label="rplI CDS" gene complement(3612512..3612961) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /label="rplI gene" downshifts complement(3612526) /Source="Nicolas_upshifts" /id="D2097" /incds=0 /nref=231 /ntot=266 /MaxReadThrough="2.69721" /MaxDrop="6.57383" /score="44.1169256" /energy="-16.6" /TU="NA" /idTUdmin="U3191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3612958..3614937) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /EC_number="3.1.4.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphodiesterase acting on cyclic dinucleotides" /protein_id="NP_391931.1" /db_xref="EnsemblGenomes-Gn:BSU40510" /db_xref="EnsemblGenomes-Tr:CAB16088" /db_xref="GOA:P37484" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR014528" /db_xref="SubtiList:BG10010" /db_xref="UniProtKB/Swiss-Prot:P37484" /translation="MPSFYEKPLFRYPIYALIALSIITILISFYFNWILGTVEVLLLA VILFFIKRADSLIRQEIDAYISTLSYRLKKVGEEALMEMPIGIMLFNDQYYIEWANPF LSSCFNESTLVGRSLYDTCESVVPLIKQEVESETVTLNDRKFRVVIKRDERLLYFFDV TEQIQIEKLYENERTVLAYIFLDNYDDVTQGLDDQTRSTMNSQVTSLLNAWAQEYGIF LKRTSSERFIAVLNEHILTELENSKFSILDEVREKTSFDGVALTLSVGVGASVSSLKE LGDLAQSSLDLALGRGGDQVAIKLPNGKVKFYGGKTNPMEKRTRVRARVISHALKEIV TESSNVIIMGHKFPDMDSIGAAIGILKVAQANNKDGFIVIDPNQIGSSVQRLIGEIKK YEELWSRFITPEEAMEISNDDTLLVIVDTHKPSLVMEERLVNKIEHIVVIDHHRRGEE FIRDPLLVYMEPYASSTAELVTELLEYQPKRLKINMIEATALLAGIIVDTKSFSLRTG SRTFDAASYLRAKGADTVLVQKFLKETVDSYIKRAKLIQHTVLYKDNIAIASLPENEE EYFDQVLIAQAADSLLSMSEVEASFAVARRDEQTVCISARSLGEVNVQIIMEALEGGG HLTNAATQLSGISVSEALERLKHAIDEYFEGGVQR*" /label="gdpP CDS" gene complement(3612958..3614937) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /label="gdpP gene" misc_feature complement(3613439..3613458) /Source="Nicolas_upshift_promotors" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3613442) /Source="Nicolas_upshifts" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3613855..3613862 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3613876..3613894 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3613880..3614546 /Source="Nicolas_S_feature" /locus_tag="new_4164565_4165231" /HighExp="LBGstat, C30, Cold, GM 10, GM 25, GM 15, GM-0.1, GM 45, GM 120, GM 90" /AntisenseName="yybT" /AntisenseCor="0.145393098609886" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1559" upshifts 3613880 /Source="Nicolas_upshifts" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3614974..3615903) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22956758; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391932.1" /db_xref="EnsemblGenomes-Gn:BSU40520" /db_xref="EnsemblGenomes-Tr:CAB16089" /db_xref="InterPro:IPR018710" /db_xref="SubtiList:BG10011" /db_xref="UniProtKB/Swiss-Prot:P37485" /translation="MKQTRALMEGAILISLFAIITLLVVYVPVIGTILLFALPLPMIL YTIRHGLKLGIWMGAVSLPVVFIVGSFNGLIVAFMSACAGIAMGHFFKRKEPGHAIIS GALIYMLSIVFYFVISIQFLGINIIDEAMTQYRQSLDIVETVAKQSGNAGQFEKQLKL MEEQLGIVQYLFPTAIVMVGVIFSFLSYLIAKPLLRRFSPDIPNLKPFRELKFPQSVV VLYLIIVMLSFLPLEKGQMLYSIALNGEFILGFLIFIQGLSFIFFYCHKKQYPKAAAV IAVILGFVHPVFMAAIRILGVLDMGFHIRNKVK*" /label="yybS CDS" gene complement(3614974..3615903) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /label="yybS gene" S_feature complement(3615904..3616040) /Source="Nicolas_S_feature" /locus_tag="new_4166589_4166725_c" /HighExp="H2O2, G150, G180, Cold, Paraq, G135, Oxctl, Salt, Etha, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1560" promotor_-10 complement(3616022..3616041) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3616040) /Source="Nicolas_upshifts" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3616056..3616061) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3616130..3616279) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097802.1" /db_xref="EnsemblGenomes-Gn:BSU40529" /db_xref="EnsemblGenomes-Tr:CAX52718" /db_xref="GOA:C0H3U2" /db_xref="UniProtKB/Swiss-Prot:C0H3U2" /translation="MWDMIKNFFLFSSGVLQATTLLLVILIFMYVRKTKKKNKESSGF MDDKH*" /label="yyzH CDS" gene complement(3616130..3616279) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /label="yyzH gene" downshifts complement(3616156) /Source="Nicolas_upshifts" /id="D2098" /incds=0 /nref=1 /ntot=44 /MaxReadThrough="6.98636" /MaxDrop="3.23568" /score="-6.7107279" /energy="-8.4" /TU="U3194" /idTUdmin="U3197" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3616318..3616337) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-10" upshifts complement(3616335) /Source="Nicolas_upshifts" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="upshifts" promotor_-35 complement(3616351..3616357) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-35" promotor_-35 3616358..3616367 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3616380..3616399 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3616386 /Source="Nicolas_upshifts" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3616398) /Source="Nicolas_upshifts" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3616400..3616913) /Source="Nicolas_S_feature" /locus_tag="new_4167085_4167598_c" /HighExp="dia5, Diami, H2O2, Salt, dia15, Etha, Paraq, LPhT, G180, C30" /AntisenseName="cotF" /AntisenseCor="-0.33406696665100499" /AntisenseRegPval="-7.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1561" promotor_-10 complement(3616402..3616416) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3616425..3616429) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3616425..3616907 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1708381, 19933362, 23335421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1708381, 19933362, 23335421; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_391933.1" /db_xref="EnsemblGenomes-Gn:BSU40530" /db_xref="EnsemblGenomes-Tr:CAB16090" /db_xref="GOA:P23261" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="InterPro:IPR016493" /db_xref="SubtiList:BG10012" /db_xref="UniProtKB/Swiss-Prot:P23261" /translation="MDERRTLAWHETLEMHELVAFQSNGLIKLKKMIREVKDPQLRQL YNVSIQGVEQNLRELLPFFPQAPHREDEEEERADNPFYSGDLLGFAKTSVRSYAIAIT ETATPQLRNVLVKQLNAAIQLHAQVYRYMYQHGYYPSYNLSELLKNDVRNANRAISMK *" /label="cotF CDS" gene 3616425..3616907 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /label="cotF gene" downshifts 3616894 /Source="Nicolas_upshifts" /id="D2099" /incds=0 /nref=20 /ntot=52 /MaxReadThrough="5.45774" /MaxDrop="4.1869" /score="-3.60126456" /energy="-16.9" /TU="U3195" /idTUdmin="U3195" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3616937..3617314) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22238377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22238377; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Cys-activated by oxidative stress)" /protein_id="NP_391934.1" /db_xref="EnsemblGenomes-Gn:BSU40540" /db_xref="EnsemblGenomes-Tr:CAB16091" /db_xref="GOA:P37486" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4A5M" /db_xref="PDB:4A5N" /db_xref="SubtiList:BG10013" /db_xref="UniProtKB/Swiss-Prot:P37486" /translation="MSEKKNIYPNKEGCPVEFTLDVIGGKWKGILFYHMIDGKKRFNE FRRICPSITQRMLTLQLRELEADGIVHREVYHQVPPKVEYSLTEFGRTLEPIVLQMKE WGESNRDVLESYRSNGLVKDQQK*" /label="hypR CDS" gene complement(3616937..3617314) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /label="hypR gene" S_feature 3616939..3617468 /Source="Nicolas_S_feature" /locus_tag="new_4167624_4168153" /HighExp="S8, S6, S7, BT, S5, B36, C30, B60, G/S, Pyr" /AntisenseName="yybR" /AntisenseCor="-0.26586375565089998" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1562" downshifts complement(3616958) /Source="Nicolas_upshifts" /id="D2100" /incds=0 /nref=124 /ntot=240 /MaxReadThrough="4.32896" /MaxDrop="5.38963" /score="10.6464065" /energy="-15.3" /TU="U3197" /idTUdmin="U3197" /TUdmin="-802" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3617369..3617388) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3617381) /Source="Nicolas_upshifts" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3617402..3617409) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3617450..3617454 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3617468..3617487 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3617470 /Source="Nicolas_upshifts" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3617495..3617509) /Source="Nicolas_upshift_promotors" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3617498) /Source="Nicolas_upshifts" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3617519..3618448 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /EC_number="3.6.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic pyrophosphatase (Mn2+-dependent)" /protein_id="NP_391935.1" /db_xref="EnsemblGenomes-Gn:BSU40550" /db_xref="EnsemblGenomes-Tr:CAB16092" /db_xref="GOA:P37487" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR004097" /db_xref="InterPro:IPR022934" /db_xref="PDB:1K23" /db_xref="PDB:1WPM" /db_xref="PDB:1WPN" /db_xref="PDB:2HAW" /db_xref="PDB:2IW4" /db_xref="SubtiList:BG10014" /db_xref="UniProtKB/Swiss-Prot:P37487" /translation="MEKILIFGHQNPDTDTICSAIAYADLKNKLGFNAEPVRLGQVNG ETQYALDYFKQESPRLVETAANEVNGVILVDHNERQQSIKDIEEVQVLEVIDHHRIAN FETAEPLYYRAEPVGCTATILNKMYKENNVKIEKEIAGLMLSAIISDSLLFKSPTCTD QDVAAAKELAEIAGVDAEEYGLNMLKAGADLSKKTVEELISLDAKEFTLGSKKVEIAQ VNTVDIEDVKKRQAELEAVISKVVAEKNLDLFLLVITDILENDSLALAIGNEAAKVEK AFNVTLENNTALLKGVVSRKKQVVPVLTDAMAE*" /label="ppaC CDS" gene 3617519..3618448 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /label="ppaC gene" downshifts 3618434 /Source="Nicolas_upshifts" /id="D2101" /incds=0 /nref=235 /ntot=270 /MaxReadThrough="2.06965" /MaxDrop="8.02492" /score="25.8885382" /energy="-11.7" /TU="NA" /idTUdmin="U3195" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3618477) /Source="Nicolas_upshifts" /id="D2102" /incds=0 /nref=14 /ntot=136 /MaxReadThrough="1.08899" /MaxDrop="4.94065" /score="19.3488922" /energy="-11.7" /TU="NA" /idTUdmin="U3200" /TUdmin=33 /isTUend="FALSE" /label="downshifts" CDS complement(3618481..3618927) /gene="yybP" /locus_tag="BSU_40560" /old_locus_tag="BSU40560" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 25794618, 25794619; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative manganese-binding lipoprotein" /protein_id="NP_391936.1" /db_xref="EnsemblGenomes-Gn:BSU40560" /db_xref="EnsemblGenomes-Tr:CAB16093" /db_xref="GOA:P37488" /db_xref="SubtiList:BG10015" /db_xref="UniProtKB/Swiss-Prot:P37488" /translation="MKIILTVLAGVGLLSAGGCGMLDQVNDGLNYTSEAAGYVEKVKT FAEEAPELAEKAVNDTEAKEKLEAQLESIQKAAADFNELTPPDAAAEIHRTIQEHNET LQKSAEDVLKQAEEGKVSLKELEQSDLVQNAKQITDVMGQIEKLGE*" /label="yybP CDS" gene complement(3618481..3618927) /gene="yybP" /locus_tag="BSU_40560" /old_locus_tag="BSU40560" /label="yybP gene" S_feature complement(3618928..3619258) /Source="Nicolas_S_feature" /locus_tag="new_4169613_4169943_c" /HighExp="S8, Cold, S7, S6, H2O2, S5, S4, Etha, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998614" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1563" misc_RNA complement(3619117..3619234) /gene="mswM" /locus_tag="BSU_misc_RNA_94" /product="manganese ion binding riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /label="mswM RNA" gene complement(3619117..3619234) /gene="mswM" /locus_tag="BSU_misc_RNA_94" /label="mswM gene" promotor_-10 complement(3619249..3619268) /Source="Nicolas_upshift_promotors" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3619257) /Source="Nicolas_upshifts" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3619282..3619289) /Source="Nicolas_upshift_promotors" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3619295..3619301 /Source="Nicolas_upshift_promotors" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3619314 /Source="Nicolas_upshifts" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3619316..3619334 /Source="Nicolas_upshift_promotors" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3619330..3619336 /Source="Nicolas_upshift_promotors" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3619351..3619362 /Source="Nicolas_upshift_promotors" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3619358 /Source="Nicolas_upshifts" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="upshifts" CDS 3619360..3620667 /gene="yybO" /locus_tag="BSU_40570" /old_locus_tag="BSU40570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_391937.1" /db_xref="EnsemblGenomes-Gn:BSU40570" /db_xref="EnsemblGenomes-Tr:CAB16094" /db_xref="GOA:P37489" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10016" /db_xref="UniProtKB/Swiss-Prot:P37489" /translation="MTEEVFIMSQERVKRPGHTRWYISSLLSGIIILNYFDRVAISVA APAIQDSFHLTATELGIVFSIYTYSYTLMQLPVGSLLDRFGVAWVTRVGMTIWSFLTI LLAFLQGKLLLYLFRFLIGLTSASAFPAASKATALWFPPSERGLANSLFDSAAKFSNV IGAPLVAFLVTTFDWRVAFLTIGCINVLFTIFFWQYYEQPERHKRISKSELNYIQKHN AITTEQIPYKTGPLLKKLFTNRKVWGLMIGFTGYGYTFNLLLTWLPTFFKHTYGMDLM SSGLFTAVPWLISTISGIAVGGWLVDYFIKKGYPNTKVYRTVIIVGMSFGFFFLGSIL TNNITVAIICISIGLAGISATAPVGWSISAELAPIGSVSMLSSMVNLANNLFGGIIAA SLTGYLFDVTGSFTLSFLVAGFVLLLGLVFYVFVLGDVKRIKL*" /label="yybO CDS" gene 3619360..3620667 /gene="yybO" /locus_tag="BSU_40570" /old_locus_tag="BSU40570" /label="yybO gene" downshifts complement(3620468) /Source="Nicolas_upshifts" /id="D2103" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="0.73662" /MaxDrop="2.97868" /score="30.543563" /energy="-17.9" /TU="NA" /idTUdmin="U3203" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 3620656 /Source="Nicolas_upshifts" /id="D2104" /incds=0 /nref=7 /ntot=55 /MaxReadThrough="2.76545" /MaxDrop="3.99898" /score="-3.44083304" /energy="-17.9" /TU="NA" /idTUdmin="U3201" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3620711..3620950) /gene="yyzI" /locus_tag="BSU_40573" /old_locus_tag="BSU40573" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52719.1" /translation="MNYKKQNQGFGSISGDHNDIHDILATIEENGTQDAFHYEGGLQG KNEQVLEQIEQEMLASGLDIEEQDEEKVNGDGPIL*" /label="yyzI CDS" gene complement(3620711..3620950) /gene="yyzI" /locus_tag="BSU_40573" /old_locus_tag="BSU40573" /pseudo /label="yyzI gene" downshifts complement(3620732) /Source="Nicolas_upshifts" /id="D2105" /incds=0 /nref=4 /ntot=114 /MaxReadThrough="3.05613" /MaxDrop="4.69729" /score="30.543563" /energy="-17.9" /TU="NA" /idTUdmin="U3203" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3620736..3620836) /Source="Nicolas_upshift_promotors" /id="U3203" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.552447552447552" /psig="0.010989010989011" /xcortree=1485 /SigmaFactorBS="gaaggtggtcttcaaggaaaaaacgagcaggtgctcgaacag atagagcaggaaatgctagcttcggggcttgatatagaggaacaggacgaggagaagg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3620776) /Source="Nicolas_upshifts" /id="U3203" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.552447552447552" /psig="0.010989010989011" /xcortree=1485 /SigmaFactorBS="gaaggtggtcttcaaggaaaaaacgagcaggtgctcgaacag atagagcaggaaatgctagcttcggggcttgatatagaggaacaggacgaggagaagg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3620940..3621104) /gene="yyzJ" /locus_tag="BSU_40574" /old_locus_tag="BSU40574" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52720.1" /translation="MMIRGIHLEQQLKDIISACDVAIQNEDFDTLMNYYSERIMCKPR KQPPQRFCEL*" /label="yyzJ CDS" gene complement(3620940..3621104) /gene="yyzJ" /locus_tag="BSU_40574" /old_locus_tag="BSU40574" /pseudo /label="yyzJ gene" CDS complement(3621116..3621301) /locus_tag="BSU_40576" /old_locus_tag="BSU40576" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514014.1" /translation="MSHQTKYPVNEAAIMPSNRLFARFTMELSMDTEPIGASSAEMDQ RNRKNKNEKDPYVSNIV*" /label="hypothetical protein CDS" gene complement(3621116..3621301) /locus_tag="BSU_40576" /old_locus_tag="BSU40576" /label="gene" downshifts 3621382 /Source="Nicolas_upshifts" /id="D2106" /incds=0 /nref=13 /ntot=90 /MaxReadThrough="0.18425" /MaxDrop="3.85413" /score="3.91893698" /energy="-13.7" /TU="NA" /idTUdmin="U3201" /TUdmin=726 /isTUend="FALSE" /label="downshifts" CDS complement(3621574..3621720) /gene="yyzK" /locus_tag="BSU_40578" /old_locus_tag="BSU40578" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52721.1" /translation="MYGKTIKKRLEKIAFLFQEISKKRKEKIERSFVGSKQLHGLSYR RFRG*" /label="yyzK CDS" gene complement(3621574..3621720) /gene="yyzK" /locus_tag="BSU_40578" /old_locus_tag="BSU40578" /pseudo /label="yyzK gene" CDS complement(3621702..3621851) /gene="yyzL" /locus_tag="BSU_40579" /old_locus_tag="BSU40579" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52722.1" /translation="MLNQHTLTYSTIDRKDYRSYKSNPEICLRILHKINETPESRYSV CMAKP*" /label="yyzL CDS" gene complement(3621702..3621851) /gene="yyzL" /locus_tag="BSU_40579" /old_locus_tag="BSU40579" /pseudo /label="yyzL gene" misc_feature complement(3622167..3622183) /Source="Nicolas_upshift_promotors" /id="U3204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.330669330669331" /psig="0.761238761238761" /xcortree=650 /SigmaFactorBS="agattaactatattatatcttaactgtaataacctgtaaaga attttattgatagtattggATTTTATGTTATAAAGGaaaaagggtgggcgatttgctc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3622184) /Source="Nicolas_upshifts" /id="U3204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.330669330669331" /psig="0.761238761238761" /xcortree=650 /SigmaFactorBS="agattaactatattatatcttaactgtaataacctgtaaaga attttattgatagtattggATTTTATGTTATAAAGGaaaaagggtgggcgatttgctc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3622203..3622210 /Source="Nicolas_upshift_promotors" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3622225..3622428 /Source="Nicolas_S_feature" /locus_tag="new_4172910_4173113" /HighExp="nit, T-3.40H, T-1.40H, T-0.40H, T0.0H, SMMPr, SMM, LoTm, ferm, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1564" promotor_-10 3622225..3622244 /Source="Nicolas_upshift_promotors" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3622225 /Source="Nicolas_upshifts" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3622246..3622260) /Source="Nicolas_upshift_promotors" /id="U3206" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=295 /SigmaFactorBS="tggggagatggagttactcctatttaaaacttcaacacaagt aataaaaaCCTCCTTTTACGTAAaagattaactatattatatcttaactgtaataacc t" /listShort="yyzL, yyzK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3622250) /Source="Nicolas_upshifts" /id="U3206" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=295 /SigmaFactorBS="tggggagatggagttactcctatttaaaacttcaacacaagt aataaaaaCCTCCTTTTACGTAAaagattaactatattatatcttaactgtaataacc t" /listShort="yyzL, yyzK" /GFF_Attribute="listLong" /label="upshifts" CDS 3622429..3622866 /gene="yybN" /locus_tag="BSU_40580" /old_locus_tag="BSU40580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27902860" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391938.1" /db_xref="EnsemblGenomes-Gn:BSU40580" /db_xref="EnsemblGenomes-Tr:CAB16095" /db_xref="InterPro:IPR020208" /db_xref="SubtiList:BG10017" /db_xref="UniProtKB/Swiss-Prot:P37490" /translation="MNKFLKSNFRFLLAAALGISLLASSNFIKASNDNYKFHLLVPYG YGNAYSNDAFRQTTHTDNPWKVNLQKSAEGKGTIMTFWLINTGNSKIPKASKIHNVKQ GSGAHYYHANSQGSHTYVALAVENNNYSASSYGIDGVWDEETW*" /label="yybN CDS" gene 3622429..3622866 /gene="yybN" /locus_tag="BSU_40580" /old_locus_tag="BSU40580" /label="yybN gene" S_feature 3622867..3622943 /Source="Nicolas_S_feature" /locus_tag="new_4173552_4173628" /HighExp="M9-tran, SMMPr, MG 120, aero, GM 120, SMM, T-2.40H, T-4.40H, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1565" downshifts 3622900 /Source="Nicolas_upshifts" /id="D2107" /incds=0 /nref=10 /ntot=98 /MaxReadThrough="6.91942" /MaxDrop="3.8662" /score="9.16494325" /energy="-9.5" /TU="U3205" /idTUdmin="U3201" /TUdmin=2244 /isTUend="FALSE" /label="downshifts" CDS 3622980..3623735 /gene="yybM" /locus_tag="BSU_40590" /old_locus_tag="BSU40590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391939.1" /db_xref="EnsemblGenomes-Gn:BSU40590" /db_xref="EnsemblGenomes-Tr:CAB16096" /db_xref="SubtiList:BG10018" /db_xref="UniProtKB/Swiss-Prot:P37491" /translation="MESHIYRIIKNKLTIIIFTIIILIPCVDISLLLMTNTEYHPAYA FFLSGTSVGHASQMILLWFLPLYFLLLCADDSIQDYKTGYHYILISKVGRKKYCLEKI FTSFIISFLTMFLSLILNFLLVQVFFFKGTFKNDLDQIKFPDNSLYTFSMAHPYIAIV LFSIICCIMSGFVGALGSSLSLLFRDKKYAYPASFFIWFVLILKNKSLMFLFQPFTEY GYNVLLPILCLSIFIFLIIISSIVLYEAKYNEN*" /label="yybM CDS" gene 3622980..3623735 /gene="yybM" /locus_tag="BSU_40590" /old_locus_tag="BSU40590" /label="yybM gene" S_feature complement(3623575..3626164) /Source="Nicolas_S_feature" /locus_tag="new_4174260_4176850_c" /HighExp="S8, S6, S4, S5, S7, S3, C30, BT, G135, T5.0H" /AntisenseName="yybK" /AntisenseCor="-0.46686696237140402" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1566" CDS 3623725..3624435 /gene="yybL" /locus_tag="BSU_40600" /old_locus_tag="BSU40600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391940.1" /db_xref="EnsemblGenomes-Gn:BSU40600" /db_xref="EnsemblGenomes-Tr:CAB16097" /db_xref="SubtiList:BG10019" /db_xref="UniProtKB/Swiss-Prot:P37492" /translation="MKIKRLLLILCLLLFLVTLWFNQNHTYLGKNSIASLLYMNNSTF GYSSIFAYTLFYIVPFLMLLSNFFHSENPYKVMRMVKRKNYYKSKIMEIGFVSLLFSS IHTVINITCTHIFFSKNLLVEANFLSICLLNMISLVFFYLSVGIMFRLTYDLFNSVAL AIFIVYIILDSLYFGVKLLLPNGYWEPFRDLAIFTNMLNRYWSTSNLIIVYIRQIIIV FIFYLVGSSIFLNKDYKK*" /label="yybL CDS" gene 3623725..3624435 /gene="yybL" /locus_tag="BSU_40600" /old_locus_tag="BSU40600" /label="yybL gene" downshifts 3623934 /Source="Nicolas_upshifts" /id="D2108" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="7.39982" /MaxDrop="2.95139" /score="9.16494325" /energy="-9.5" /TU="U3205" /idTUdmin="U3205" /TUdmin="-2354" /isTUend="FALSE" /label="downshifts" CDS 3624432..3625187 /gene="yybK" /locus_tag="BSU_40610" /old_locus_tag="BSU40610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391941.1" /db_xref="EnsemblGenomes-Gn:BSU40610" /db_xref="EnsemblGenomes-Tr:CAB16098" /db_xref="InterPro:IPR024295" /db_xref="SubtiList:BG10020" /db_xref="UniProtKB/Swiss-Prot:P37493" /translation="MRIKGFFITLVAIIFQASLSSYNNNKNVFPFLDGIPISTSGHYE YQNILLWFVPIVSLSFCFSGSIRDTYISYEQLKLVREHSRVKWVTSQFLIITVVLLIF TLSQIAIFYIYSLVSLHNLDINSVINKRFVMMTLMYYLTLLNLFSFQLFMELYYKSQI AQLNISVYIIFSLILAKKLVQLNSPKVIHYFLIPNYSNGLRTGLSYYSQSGTAIIEPL LGLFIIIILQISIVILSVLKFKKIDMLKSEGLQ*" /label="yybK CDS" gene 3624432..3625187 /gene="yybK" /locus_tag="BSU_40610" /old_locus_tag="BSU40610" /label="yybK gene" CDS 3625184..3625839 /gene="yybJ" /locus_tag="BSU_40620" /old_locus_tag="BSU40620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1938973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-binding cassette subunit of transporter" /protein_id="NP_391942.1" /db_xref="EnsemblGenomes-Gn:BSU40620" /db_xref="EnsemblGenomes-Tr:CAB16099" /db_xref="GOA:P37494" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10021" /db_xref="UniProtKB/Swiss-Prot:P37494" /translation="MIEVLNLTKKLKRLQF*IISLIHLKKEQFMDYLGVMVLERPCYF VHYPG**SLLKGV*LLKVNNYIKISLFLKV*D*L*KICSYFLSMMLLLTLKFCQKLKR SHQIMIY*ILLVELVWKILIV*RLVNSR*E*NND*ILHRLFLKNLIYCYLMNQQMRLM KKELHLFMTFFYKRKKGELPLLLLVITRKILYLYVTLH*K*IMDV*KLQKK*YIRKIV " /label="yybJ CDS" gene 3625184..3625839 /gene="yybJ" /locus_tag="BSU_40620" /old_locus_tag="BSU40620" /label="yybJ gene" S_feature 3625840..3626154 /Source="Nicolas_S_feature" /locus_tag="new_4176526_4176840" /HighExp="aero, Cold, HPh, nit, M/G, M9-tran, S1, SMM, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1567" downshifts 3626111 /Source="Nicolas_upshifts" /id="D2109" /incds=0 /nref=93 /ntot=227 /MaxReadThrough="3.45614" /MaxDrop="4.54398" /score="2.19825508" /energy="-10.3" /TU="U3205" /idTUdmin="U3205" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 3626155 /Source="Nicolas_upshifts" /id="D2110" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.98662" /MaxDrop="3.29879" /score="2.19825508" /energy="-10.3" /TU="U3205" /idTUdmin="U3205" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts complement(3626209) /Source="Nicolas_upshifts" /id="D2111" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.53364" /MaxDrop="2.25148" /score="10.1219981" /energy="-6.3" /TU="U3207" /idTUdmin="U3209" /TUdmin=2266 /isTUend="FALSE" /label="downshifts" CDS complement(3626214..3627002) /gene="ictI" /locus_tag="BSU_40630" /old_locus_tag="BSU40630" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16321932, 22882546, 25835496" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932, 22882546, 25835496; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391943.1" /db_xref="EnsemblGenomes-Gn:BSU40630" /db_xref="EnsemblGenomes-Tr:CAB16100" /db_xref="SubtiList:BG10022" /db_xref="UniProtKB/Swiss-Prot:P37495" /translation="MNVYDIRMAPYWFYEGRGLVQHPYVFRQPVSSRAIIVSTRGDVT GDGVIDEVFLTGNQMPGSPLWRNITLVIRDGRTHQEQRIQLQNNMGYNPSLFLGDMTG DKIEDVAVVMDTGGSGGAIYAYVFAYLNRQFRRIFNSDVLNDELKYSVRYQNQYKASV ISHQQNETYILDLTYKGREYLNEIYNSQGVLKMPIEGWVNPLSGLYPVDFDRDGVYEL LAYQRIAGRYNADSLGYVQTVLKWNGQRFMFNRQTVTIFGSDLS*" /label="ictI CDS" gene complement(3626214..3627002) /gene="ictI" /locus_tag="BSU_40630" /old_locus_tag="BSU40630" /label="ictI gene" promotor_-10 complement(3627026..3627044) /Source="Nicolas_upshift_promotors" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3627045) /Source="Nicolas_upshifts" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3627060..3627065) /Source="Nicolas_upshift_promotors" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3627070..3627459) /gene="yybH" /locus_tag="BSU_40640" /old_locus_tag="BSU40640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391944.1" /db_xref="EnsemblGenomes-Gn:BSU40640" /db_xref="EnsemblGenomes-Tr:CAB16101" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:2GXF" /db_xref="SubtiList:BG10023" /db_xref="UniProtKB/Swiss-Prot:P37496" /translation="MEQQLKDIISACDLAIQNEDFDTLMNYYSEDAVLVVKPGMIARG KEEIKKAFITIANYFNHHIVPTQGKMILLEAGDTVLVLSQTLLDSDKKDSEYAMERRA TYVFKKNAQGEWLCVIDNSYGTDLIGV*" /label="yybH CDS" gene complement(3627070..3627459) /gene="yybH" /locus_tag="BSU_40640" /old_locus_tag="BSU40640" /label="yybH gene" promotor_-35 3627528..3627531 /Source="Nicolas_upshift_promotors" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3627546..3627565 /Source="Nicolas_upshift_promotors" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3627559 /Source="Nicolas_upshifts" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="upshifts" CDS 3627605..3628444 /gene="yybG" /locus_tag="BSU_40650" /old_locus_tag="BSU40650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11709313, 12486061" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391945.1" /db_xref="EnsemblGenomes-Gn:BSU40650" /db_xref="EnsemblGenomes-Tr:CAB16102" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG10024" /db_xref="UniProtKB/Swiss-Prot:P37497" /translation="MSAEVTLHDNIHYDLSADCQHCFGLCCVALPYAKSADFAFDKDG GTPCRNLQSNYQCSIHKDLREKGFRGCSAYECFGAGQKVSQITYEGKDWRNSPETANQ MFDVFPIMQQLHEMLWYLHEALSIDIAKPIHSELRTTFEKIERLTRLSKERLLTLQVD EHRAEVNEWLLKTSELVRAQARHPKLPKKVSRGSVLIGAKLKGLDLRGANLRGALLIA ADLRNADLRMTDFIGADMRDADLSGADLTGSIFLTQAQVNAANGDSNTKLPLSVRTPA HWK*" /label="yybG CDS" gene 3627605..3628444 /gene="yybG" /locus_tag="BSU_40650" /old_locus_tag="BSU40650" /label="yybG gene" downshifts 3628421 /Source="Nicolas_upshifts" /id="D2112" /incds=0 /nref=35 /ntot=188 /MaxReadThrough="1.19247" /MaxDrop="3.72166" /score="-0.156630814" /energy="-6.3" /TU="NA" /idTUdmin="U3208" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3628477..3629691) /gene="yybF" /locus_tag="BSU_40660" /old_locus_tag="BSU40660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811656, 11557812, 12486061, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_391946.1" /db_xref="EnsemblGenomes-Gn:BSU40660" /db_xref="EnsemblGenomes-Tr:CAB16103" /db_xref="GOA:P37498" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10025" /db_xref="UniProtKB/Swiss-Prot:P37498" /translation="MTYIRKGTPVFRKITFAFFAAGFNTFAILYCVQPLMEEFTREFH VTPTAASLSLSVTTMLLAVSMLVFGSLSEVWGRKPIMGISMLAASVLCLASAFSPSFH TLLVLRTIQGVALAGLPSIAMAYLGEEIEPGSLGSAMGLYISGNAIGAVFGRIVSGLL SEYLNWHMAMGTIGVISLIASVIFFINLPPSRHFTPRKLKLGKLGMSLIGHLRDRKLF SLFLIGFLLLGSNVALFNYIVYVLLGPPYSLNKAFSSWIFIVMIVGIFSSSFIGRMVD RYGYPKILVMNIFIVIAGALFTINNMLAVKILGIALFTFGFFGGHSVASSWVGRRALH NKAQASSLYLFFYYAGSSVFGTIGGLFWSGFHWLGVVGMITFMLLVALWLSGYLARSV KMPDKRNEKGLN*" /label="yybF CDS" gene complement(3628477..3629691) /gene="yybF" /locus_tag="BSU_40660" /old_locus_tag="BSU40660" /label="yybF gene" downshifts complement(3628495) /Source="Nicolas_upshifts" /id="D2113" /incds=0 /nref=45 /ntot=169 /MaxReadThrough="1.92237" /MaxDrop="5.70619" /score="10.1219981" /energy="-6.3" /TU="NA" /idTUdmin="U3209" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(3629692..3629795) /Source="Nicolas_S_feature" /locus_tag="new_4180378_4180481_c" /HighExp="BI, B60, ferm, T0.30H, T-1.10H, T-0.40H, T-1.40H, T1.0H, nit, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.94819299999999995" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1568" promotor_-10 complement(3629788..3629807) /Source="Nicolas_upshift_promotors" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3629796..3629803 /Source="Nicolas_upshift_promotors" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3629798) /Source="Nicolas_upshifts" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3629817..3629836 /Source="Nicolas_upshift_promotors" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3629821..3629828) /Source="Nicolas_upshift_promotors" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3629829 /Source="Nicolas_upshifts" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="upshifts" CDS 3629878..3630756 /gene="yybE" /locus_tag="BSU_40670" /old_locus_tag="BSU40670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591, 17526699, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391947.2" /db_xref="EnsemblGenomes-Gn:BSU40670" /db_xref="EnsemblGenomes-Tr:CAB16104" /db_xref="GOA:P37499" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10026" /db_xref="UniProtKB/Swiss-Prot:P37499" /translation="MEWEQLEYFQTLARMQHVTKAAKSLSITQPALSRSIARLENHLG VPLFDRQGRSISLNQYGHIFLRRVQAMMKEYTEGKEEIQALLKPDQGVVSLGFLHTLG TTLVPDLIGSFQQEYPNISFQLKQNHSYWLLERLKSGDLDLCLLASIKPENPIQWIKL WSEELFVFVPNDHPLASRESITLNEIAGERFILLKKGYALRMTVDELFEKANIQPNIM FEGEEATTAAGFVAAGLGISILPDLKGLDQSKITKIRVSWPECQRVIGIAWIKGRFLS PVAETFKQYVISHFSE*" /label="yybE CDS" gene 3629878..3630756 /gene="yybE" /locus_tag="BSU_40670" /old_locus_tag="BSU40670" /label="yybE gene" CDS 3630770..3631213 /gene="yybD" /locus_tag="BSU_40680" /old_locus_tag="BSU40680" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_391948.1" /db_xref="EnsemblGenomes-Gn:BSU40680" /db_xref="EnsemblGenomes-Tr:CAB16105" /db_xref="GOA:P37500" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10027" /db_xref="UniProtKB/Swiss-Prot:P37500" /translation="MNVKKITSEQDLHTAFEIRKAVFVEEQGCPISDEFDEFDTLHGD CQHILAYHQNVPVGTARVRIVGHTGKLERICILKSYRKFGLGKVIVDALERIVKEQGI SAFKLHGQTQAAGFYEKLGYRTASEEFMLDGIPHVLMTKQDDSAL*" /label="yybD CDS" gene 3630770..3631213 /gene="yybD" /locus_tag="BSU_40680" /old_locus_tag="BSU40680" /label="yybD gene" CDS 3631296..3631775 /gene="yybC" /locus_tag="BSU_40690" /old_locus_tag="BSU40690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28032445; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391949.1" /db_xref="EnsemblGenomes-Gn:BSU40690" /db_xref="EnsemblGenomes-Tr:CAB16106" /db_xref="SubtiList:BG10028" /db_xref="UniProtKB/Swiss-Prot:P37501" /translation="MPANKKEGLIFGVMMCFGMVCVMSIYNAIINRAIYDFSLMTVFE MVIGFMIALLLDLLLVGPLAKKIAFRMPFDKTKKIYVILAMSTCMVIGMVLCMSVFGL VTAVLANGLNGDSLFSAYLMIVLKNFILAYPLQLLIMGPLVRGVFMKFVKPKLTAAI* " /label="yybC CDS" gene 3631296..3631775 /gene="yybC" /locus_tag="BSU_40690" /old_locus_tag="BSU40690" /label="yybC gene" downshifts 3631765 /Source="Nicolas_upshifts" /id="D2114" /incds=0 /nref=13 /ntot=97 /MaxReadThrough="0.69144" /MaxDrop="3.55998" /score="-9.53342462" /energy="-10.9" /TU="NA" /idTUdmin="U3210" /TUdmin=1628 /isTUend="FALSE" /label="downshifts" CDS complement(3631950..3632612) /gene="yybB" /locus_tag="BSU_40700" /old_locus_tag="BSU40700" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391950.1" /db_xref="EnsemblGenomes-Gn:BSU40700" /db_xref="EnsemblGenomes-Tr:CAB16107" /db_xref="GOA:P37502" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10029" /db_xref="UniProtKB/Swiss-Prot:P37502" /translation="MNLRQLSEHVFQCEFELDVPLRIPVHTWFIKDGDDVYIVDTGIE RFADAQIRAALAIGNPKAILLTHGHSDHIGGASKWLERFDIPIFAHQKELKYINGEEP YPNKNEVENTGVAHIVQPLTEQTLAHLPLKYYLTPGHSPGHVVYYHKIDRTLLTGDLF ITSKEDLHPPIRRFSVDINENIDSGSIIDQIKPTLICSSHGEEILYNEELYKNYVVRY RD*" /label="yybB CDS" gene complement(3631950..3632612) /gene="yybB" /locus_tag="BSU_40700" /old_locus_tag="BSU40700" /label="yybB gene" CDS complement(3632759..3633211) /gene="yybA" /locus_tag="BSU_40710" /old_locus_tag="BSU40710" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, polyamine export and degradation)" /protein_id="NP_391951.1" /db_xref="EnsemblGenomes-Gn:BSU40710" /db_xref="EnsemblGenomes-Tr:CAB16108" /db_xref="GOA:P37503" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10030" /db_xref="UniProtKB/Swiss-Prot:P37503" /translation="MNDILREIGMIARALDSISNIEFKDLDLTRGQYLYLVRIYENPG IIQEKLAEMIKVDRTTAARAIKKLEMQGFIQKLPDEQNKKIKKLFPTEKGKKVYPLLR REGEHSTEVALSGFTSEEKETISALLHRVRKNIERDWEYVKKGNKRDY*" /label="yybA CDS" gene complement(3632759..3633211) /gene="yybA" /locus_tag="BSU_40710" /old_locus_tag="BSU40710" /label="yybA gene" promotor_-35 3633235..3633242 /Source="Nicolas_upshift_promotors" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3633257..3633276 /Source="Nicolas_upshift_promotors" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3633259 /Source="Nicolas_upshifts" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="upshifts" S_feature 3633261..3633330 /Source="Nicolas_S_feature" /locus_tag="new_4183947_4184016" /HighExp="G135, G180, H2O2, LoTm, G150, Salt, Diami, Paraq, LBGstat, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1569" promotor_-10 complement(3633264..3633283) /Source="Nicolas_upshift_promotors" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3633266) /Source="Nicolas_upshifts" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3633296..3633303) /Source="Nicolas_upshift_promotors" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3633331..3633777 /gene="yyaT" /locus_tag="BSU_40720" /old_locus_tag="BSU40720" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase (polyamine degradation)" /protein_id="NP_391952.1" /db_xref="EnsemblGenomes-Gn:BSU40720" /db_xref="EnsemblGenomes-Tr:CAB16109" /db_xref="GOA:P37504" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10031" /db_xref="UniProtKB/Swiss-Prot:P37504" /translation="MNIKRITTEADLHEALKIRRGVFIEEQHVSEADEFDEFDTLQEQ CQHILVYHENQPVGTGRARIVGHTAKLERICILKPYRKYGLGKIIVSGLEEIMKEKGL TSYKLHGQTQAAGFYQKLGYQISSQEFMEDGIPHVLMTKEISRNIT*" /label="yyaT CDS" gene 3633331..3633777 /gene="yyaT" /locus_tag="BSU_40720" /old_locus_tag="BSU40720" /label="yyaT gene" CDS 3633774..3634379 /gene="yyaS" /locus_tag="BSU_40730" /old_locus_tag="BSU40730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391953.1" /db_xref="EnsemblGenomes-Gn:BSU40730" /db_xref="EnsemblGenomes-Tr:CAB16110" /db_xref="SubtiList:BG10032" /db_xref="UniProtKB/Swiss-Prot:P37505" /translation="MKYMYYGIGILILSLGISLTIQSGLGTSPFDALLVGLSKKIGLT VGSWEVLISVILLICNAILTRKKPILLGLITAFITGIGIDLWLFVVKNTIYLNSLLSK LICFGIGLVLIGLGTAIYLQTKFASTPIDHLTLIIRDLSKRTILFSRTLVYALFLVLA IIFKGPIGIGTLLTVCLGGMLLHVFMPIVERHFLSKNRRGY*" /label="yyaS CDS" gene 3633774..3634379 /gene="yyaS" /locus_tag="BSU_40730" /old_locus_tag="BSU40730" /label="yyaS gene" CDS complement(3634474..3634995) /gene="yyaR" /locus_tag="BSU_40740" /old_locus_tag="BSU40740" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16579456, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyl-transferase" /protein_id="NP_391954.1" /db_xref="EnsemblGenomes-Gn:BSU40740" /db_xref="EnsemblGenomes-Tr:CAB16111" /db_xref="GOA:P37506" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR008125" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10033" /db_xref="UniProtKB/Swiss-Prot:P37506" /translation="MIMKMTHLNMKDFNKPNEPFVVFGRMIPAFENGVWTYTEERFSK PYFKQYEDDDMDVSYVEEEGKAAFLYYLENNCIGRIKIRSNWNGYALIEDIAVAKDYR KKGVGTALLHKAIEWAKENHFCGLMLETQDINISACHFYAKHHFIIGAVDTMLYSNFP TANEIAIFWYYKF*" /label="yyaR CDS" gene complement(3634474..3634995) /gene="yyaR" /locus_tag="BSU_40740" /old_locus_tag="BSU40740" /label="yyaR gene" S_feature complement(3634996..3635823) /Source="Nicolas_S_feature" /locus_tag="new_4185682_4186509_c" /HighExp="T0.30H, Lbstat, H2O2, LPhT, T1.0H, dia15, Diami, T1.30H, dia5, M9-stat" /AntisenseName="yyaQ" /AntisenseCor="0.51412050904654805" /AntisenseRegPval="-18.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1570" promotor_-35 3635044..3635051 /Source="Nicolas_upshift_promotors" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3635065 /Source="Nicolas_upshifts" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3635066..3635085 /Source="Nicolas_upshift_promotors" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3635131..3635405 /Source="Nicolas_S_feature" /locus_tag="new_4185817_4186091" /HighExp="LBGstat, G135, BC, G180, Sw, M9-stat, Diami, T0.30H, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13713" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1571" upshifts 3635131 /Source="Nicolas_upshifts" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3635134..3635139 /Source="Nicolas_upshift_promotors" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3635152..3635171 /Source="Nicolas_upshift_promotors" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3635406..3635762 /gene="yyaQ" /locus_tag="BSU_40750" /old_locus_tag="BSU40750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391955.1" /db_xref="EnsemblGenomes-Gn:BSU40750" /db_xref="EnsemblGenomes-Tr:CAB16112" /db_xref="InterPro:IPR007351" /db_xref="SubtiList:BG10034" /db_xref="UniProtKB/Swiss-Prot:P37507" /translation="MLTREDIFKHVKEKYGTSPDYPWEKYPNYASLRHTSNKKWYGLI MNVLPEKLGLDGHGEIDILNLKCPPEISDRLRNGENILPGYHMDKEHWISIVLERTDP EGEIYNLIEQSFHLTK*" /label="yyaQ CDS" gene 3635406..3635762 /gene="yyaQ" /locus_tag="BSU_40750" /old_locus_tag="BSU40750" /label="yyaQ gene" S_feature 3635763..3635921 /Source="Nicolas_S_feature" /locus_tag="new_4186449_4186607" /HighExp="Sw, BC, G135, H2O2, LBGstat, G180, LPhT, T0.30H, Diami, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1572" promotor_-10 complement(3635805..3635824) /Source="Nicolas_upshift_promotors" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3635823) /Source="Nicolas_upshifts" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3635839..3635846) /Source="Nicolas_upshift_promotors" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3635922..3636488 /gene="yyaP" /locus_tag="BSU_40760" /old_locus_tag="BSU40760" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391956.1" /db_xref="EnsemblGenomes-Gn:BSU40760" /db_xref="EnsemblGenomes-Tr:CAB16113" /db_xref="GOA:P37508" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="PDB:2GD9" /db_xref="SubtiList:BG10035" /db_xref="UniProtKB/Swiss-Prot:P37508" /translation="MTNNLKQRRIILDLAVTLDGFIEGKNGEVDWCIMDPDMGFTDFL NQIDTILYGRKSFDLWGQYIPKNEDPDTEKELWKLVHSKKKYVFSRTQNEIDNQAIFI NDNILEEVNKLKKNPGKDIWLYGGASLITTFINLGLVDEFRLSIHPVVLGEGKPLFID VKQRINLKMVNTRTFSSGVVQIVYHWNG*" /label="yyaP CDS" gene 3635922..3636488 /gene="yyaP" /locus_tag="BSU_40760" /old_locus_tag="BSU40760" /label="yyaP gene" CDS complement(3636995..3638371) /gene="tetB" /locus_tag="BSU_40770" /old_locus_tag="BSU40770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7961647, 14636065, 15849754, 16850406, 17015648, 25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7961647, 14636065, 15849754, 16850406, 17015648, 25954268; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multifunctional tetracycline-metal/H+ antiporterand Na+(K+)/H+ antiporter" /protein_id="NP_391957.1" /db_xref="EnsemblGenomes-Gn:BSU40770" /db_xref="EnsemblGenomes-Tr:CAB16114" /db_xref="GOA:P23054" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10036" /db_xref="UniProtKB/Swiss-Prot:P23054" /translation="MNTSYSQSTLRHNQVLIWLCVLSFFSVLNEMVLNVSLPDIANEF NKLPASANWVNTAFMLTFSIGTALYGKLSDQLGIKNLLLFGIMVNGLGSIIGFVGHSF FPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGG MVAHYIHWSYLLLIPTATIITVPFLIKLLKKEERIRGHIDMAGIILMSAGIVFFMLFT TSYRFSFLIISILAFFIFVQHIRKAQDPFVDPELGKNVFFVIGTLCGGLIFGTVAGFV SMVPYMMKDVHHLSTAAIGSGIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALLS SGFLIAAFFIDAAPWIMTIIVIFVFGGLSFTKTVISTVVSSSLKEKEAGAGMSLLNFT SFLSEGTGIAIVGGLLSIGFLDHRLLPIDVDHSTYLYSNMLILFAGIIVICWLVILNV YKRSRRHG*" /label="tetB CDS" gene complement(3636995..3638371) /gene="tetB" /locus_tag="BSU_40770" /old_locus_tag="BSU40770" /label="tetB gene" CDS complement(3638405..3638467) /gene="tetL" /locus_tag="BSU_40780" /old_locus_tag="BSU40780" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14636065, 17015648" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636065, 17015648; Product type t: transporter" /codon_start=1 /transl_table=11 /product="tetracycline resistance leader peptide" /protein_id="NP_391958.1" /db_xref="EnsemblGenomes-Gn:BSU40780" /db_xref="EnsemblGenomes-Tr:CAB16115" /db_xref="GOA:P23053" /db_xref="InterPro:IPR012618" /db_xref="SubtiList:BG11051" /db_xref="UniProtKB/Swiss-Prot:P23053" /translation="MKCNKMNRVQLKEGSVSMTL*" /label="tetL CDS" gene complement(3638405..3638467) /gene="tetL" /locus_tag="BSU_40780" /old_locus_tag="BSU40780" /label="tetL gene" promotor_-10 complement(3638488..3638507) /Source="Nicolas_upshift_promotors" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3638507) /Source="Nicolas_upshifts" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3638520..3638527) /Source="Nicolas_upshift_promotors" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3638655..3638661 /Source="Nicolas_upshift_promotors" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3638677..3638696 /Source="Nicolas_upshift_promotors" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3638683 /Source="Nicolas_upshifts" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="upshifts" CDS 3638720..3638959 /gene="yyaO" /locus_tag="BSU_40790" /old_locus_tag="BSU40790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391959.1" /db_xref="EnsemblGenomes-Gn:BSU40790" /db_xref="EnsemblGenomes-Tr:CAB16116" /db_xref="InterPro:IPR004879" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10037" /db_xref="UniProtKB/Swiss-Prot:P37509" /translation="MPNKSKPNRLIAEKSPYLLQHAHNPVDWFPWGEEAFAKAKRENK PVLVSIGYSTTCHWWPGIIKSCGTPLKDNRSHFKR*" /label="yyaO CDS" gene 3638720..3638959 /gene="yyaO" /locus_tag="BSU_40790" /old_locus_tag="BSU40790" /label="yyaO gene" downshifts 3638968 /Source="Nicolas_upshifts" /id="D2115" /incds=0 /nref=7 /ntot=103 /MaxReadThrough="1.03879" /MaxDrop="3.89186" /score="10.758481" /energy="-8.2" /TU="NA" /idTUdmin="U3217" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 3639052..3639059 /Source="Nicolas_upshift_promotors" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3639075..3639094 /Source="Nicolas_upshift_promotors" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3639091 /Source="Nicolas_upshifts" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="upshifts" CDS 3639110..3639526 /gene="yyaN" /locus_tag="BSU_40800" /old_locus_tag="BSU40800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948146, 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MerR family)" /protein_id="NP_391960.1" /db_xref="EnsemblGenomes-Gn:BSU40800" /db_xref="EnsemblGenomes-Tr:CAB16117" /db_xref="GOA:P37510" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG10038" /db_xref="UniProtKB/Swiss-Prot:P37510" /translation="MLLYSISKAAEKTSISSYTLRYYEKIGLLPPPKRKNSGRRFYTE TDIQFMLFLKSLKETGMSLEDINEFVKDGCILEKINSDVKSAQLSPSINKRIEILTKH LEKMEIKKRELEEVISTTKGKLDTYYSILKEEVENK*" /label="yyaN CDS" gene 3639110..3639526 /gene="yyaN" /locus_tag="BSU_40800" /old_locus_tag="BSU40800" /label="yyaN gene" CDS 3639523..3640440 /gene="yyaM" /locus_tag="BSU_40810" /old_locus_tag="BSU40810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391961.1" /db_xref="EnsemblGenomes-Gn:BSU40810" /db_xref="EnsemblGenomes-Tr:CAB16118" /db_xref="GOA:P37511" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10039" /db_xref="UniProtKB/Swiss-Prot:P37511" /translation="MKHLNIYIMLLGFSIFTGATFNLAKYTVGYFSPSSSAAWRFGLA AAVMLIILIFTEGIKKSQLRKNAVSYIVLGIIGIFGFNALFFVGLKYTSPVNGALIMG LNPLLTAILARIILKDNMTKKQVLGIFFAFIGVLLVITQGSIETIKTLSISGGDLIIF TGNVCWALYGVLGRRFVKDGTPLSTTTYTMVIGAVSLIVVSLFTSKPVSLSNIPIGVW GAIAFMAFFTSVLGYLWWNQGIKEIGASKTSLFFNLVPVVTMIISFAVGTPIKVFQVI GAVLVILGVLTASGVIRIPKYNTKEQSAI*" /label="yyaM CDS" gene 3639523..3640440 /gene="yyaM" /locus_tag="BSU_40810" /old_locus_tag="BSU40810" /label="yyaM gene" misc_feature 3640467..3640486 /Source="Nicolas_upshift_promotors" /id="U3219" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig="0.984015984015984" /xcortree=1462 /SigmaFactorBS="actaaagaacagtcagctatataaagaaatagggagtatttt tgagaaaaTGTGTTAAGTTAAATATACActaattataggaagaaggtgatcccatgcc a" /listShort="yyaL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3640477 /Source="Nicolas_upshifts" /id="U3219" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig="0.984015984015984" /xcortree=1462 /SigmaFactorBS="actaaagaacagtcagctatataaagaaatagggagtatttt tgagaaaaTGTGTTAAGTTAAATATACActaattataggaagaaggtgatcccatgcc a" /listShort="yyaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3640481..3640500) /Source="Nicolas_upshift_promotors" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3640487) /Source="Nicolas_upshifts" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3640512..3642581 /gene="yyaL" /locus_tag="BSU_40820" /old_locus_tag="BSU40820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391962.1" /db_xref="EnsemblGenomes-Gn:BSU40820" /db_xref="EnsemblGenomes-Tr:CAB16119" /db_xref="GOA:P37512" /db_xref="InterPro:IPR004879" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR024705" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10040" /db_xref="UniProtKB/Swiss-Prot:P37512" /translation="MPNKSKPNRLINEKSPYLLQHAHNPVDWFPWGEEAFEKAKRENK PVLVSIGYSTCHWCHVMAHESFEDEEIARLLNERFVAIKVDREERPDVDSVYMRICQL MTGQGGWPLNVFITPDQKPFYAGTYFPKTSKFNRPGFVDVLEHLSETFANDREHVEDI AENAAKHLQTKTAAKTGEGLSESAIHRTFQQLASGFDTIYGGFGQAPKFPMPHMLMYL LRYDHNTGQENALYNVTKTLDSMANGGIYDHIGYGFARYSTDDEWLVPHFEKMLYDNA LLLTAYTEAYQVTQNSRYKEICEQIITFIQREMTHEDGSFFSALDADTEGEEGKYYVW SKEEILKTLGDDLGTLYCQVYDITEEGNFEGKNIPNLIHTKREQIKEDAGLTEKELSL KLEDARQQLLKTREERTYPHVDDKVLTSWNALMIAGLAKAAKVYQEPKYLSLAKDAIT FIENKLIIDGRVMVRYRDGEVKNKGFIDDYAFLLWAYLDLYEASFDLSYLQKAKKLTD DMISLFWDEEHGGFYFTGHDAEALIVREKEVYDGAVPSGNSVAAVQLLRLGQVTGDLS LIEKAETMFSVFKPDIEAYPSGHAFFMQSVLRHLMPKKEIVIFGSADDPARKQIIAEL QKAFKPNDSILVAEQPEQCKDIAPFAADYRIIDGKTTVYICENFACQQPTTNIEEAIH TLISSRD*" /label="yyaL CDS" gene 3640512..3642581 /gene="yyaL" /locus_tag="BSU_40820" /old_locus_tag="BSU40820" /label="yyaL gene" promotor_-35 complement(3640514..3640521) /Source="Nicolas_upshift_promotors" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3642545 /Source="Nicolas_upshifts" /id="D2116" /incds=0 /nref=221 /ntot=260 /MaxReadThrough="1.24617" /MaxDrop="5.71843" /score="11.6894527" /energy="-16.6" /TU="NA" /idTUdmin="U3219" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3642578..3643477) /gene="yyaK" /locus_tag="BSU_40830" /old_locus_tag="BSU40830" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11343912, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protease" /protein_id="NP_391963.1" /db_xref="EnsemblGenomes-Gn:BSU40830" /db_xref="EnsemblGenomes-Tr:CAB16120" /db_xref="GOA:P37513" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG10041" /db_xref="UniProtKB/Swiss-Prot:P37513" /translation="MNSFIRPIEGNNTLWRYFFAFLVMVGLYVLGNIAYLFAILFTVI VNPNITFDLDEAVLSDPLVDLYLSHVIYLFAIPGVWLAVRFILKRPFRTVITPNSKMN WRRISFGFIAYFLLMIAVQLIDFVIHPDSYSMQEFNASRFIWLLAAALILVPIQTSAE ELFFRGFLLQAFGRLTKNPLFLTLIVGGLFGVLHFANPEMNNGAVWAGIEYLTFGFVW TYYTIKTGSIEISLGAHAANNMFLCMFITEKNSVYGGIPSLFTVTRGNPMWEAFFTIA VNLVFAGIALWYHKKSKSKQQGS*" /label="yyaK CDS" gene complement(3642578..3643477) /gene="yyaK" /locus_tag="BSU_40830" /old_locus_tag="BSU40830" /label="yyaK gene" downshifts complement(3642621) /Source="Nicolas_upshifts" /id="D2117" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="2.6155" /MaxDrop="3.91098" /score="23.2445146" /energy="-14.7" /TU="NA" /idTUdmin="U3221" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3643506..3643525) /Source="Nicolas_upshift_promotors" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3643522) /Source="Nicolas_upshifts" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3643524..3644755) /Source="Nicolas_S_feature" /locus_tag="new_4194210_4195441_c" /HighExp="S6, S8, S7, S5, B36, BT, S4, B60, S3, Diami" /AntisenseName="yyaJ" /AntisenseCor="-0.24400480530035801" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1573" promotor_-35 complement(3643540..3643547) /Source="Nicolas_upshift_promotors" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3643618..3643625 /Source="Nicolas_upshift_promotors" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3643639..3643658 /Source="Nicolas_upshift_promotors" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3643645 /Source="Nicolas_upshifts" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 3643703..3645058 /gene="yyaJ" /locus_tag="BSU_40840" /old_locus_tag="BSU40840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 9529885, 19087206, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391964.2" /db_xref="EnsemblGenomes-Gn:BSU40840" /db_xref="EnsemblGenomes-Tr:CAB16121" /db_xref="GOA:P37514" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10042" /db_xref="UniProtKB/Swiss-Prot:P37514" /translation="MNTIFKQKNTHPFSNAANRLDRLPISRVHFQVLTALGIVYFFDL ADLFTLSNVAPALIEHWGIPLSTIANVTAASFLGMFLGASLGGRLSDRIGRKKALNLF VFVFSIASLCNAAAWDIPSLMTFRFLTGFGVAAAMVITNSYLAEFFPSSVRGKYISFC AMIGLIGVPITNIVSAFVIPLGSWGWRLVFVWGAVGLIYFFFIHRLEESPRWHENRGE YAKADAILTRIEEQVEKEKGPLPAASQPKVSETVKQNAGYAGLLKGRNLKITIVLSAV WIFETFGFYGFASWVPSLLKSNGVTMENTLWYNVLHSVGAPLGALLGSMISERFQRKW ILAASAFLTAIAGLLYGMTFIPIMIIVFGFIVNITERVFTSNLYAYTSEPYPTEYRSS GSGLAYGLGRFSNIFGSLLVGFIAVQLGYISVFLFIGGCWLACSLLLIFFGPNTNAKQ I*" /label="yyaJ CDS" gene 3643703..3645058 /gene="yyaJ" /locus_tag="BSU_40840" /old_locus_tag="BSU40840" /label="yyaJ gene" promotor_-10 complement(3644741..3644760) /Source="Nicolas_upshift_promotors" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3644765) /Source="Nicolas_upshifts" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3644774..3644783) /Source="Nicolas_upshift_promotors" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3645092..3645646) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /EC_number="2.3.1.79" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12731863, 12793527, 19087206, 22226636, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose O-acetyltransferase" /protein_id="NP_391965.1" /db_xref="EnsemblGenomes-Gn:BSU40850" /db_xref="EnsemblGenomes-Tr:CAB16122" /db_xref="GOA:P37515" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR024688" /db_xref="SubtiList:BG10043" /db_xref="UniProtKB/Swiss-Prot:P37515" /translation="MLRTEKEKMAAGELYNSEDQQLLLERKHARQLIRQYNETPEDDA VRTKLLKELLGSVGDQVTILPTFRCDYGYHIHIGDHTFVNFDCVILDVCEVRIGCHCL IAPGVHIYTAGHPLDPIERKSGKEFGKPVTIGDQVWIGGRAVINPGVTIGDNAVIASG SVVTKDVPANTVVGGNPARILKQL*" /label="maa CDS" gene complement(3645092..3645646) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /label="maa gene" CDS complement(3645664..3646044) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19087206; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_391966.1" /db_xref="EnsemblGenomes-Gn:BSU40860" /db_xref="EnsemblGenomes-Tr:CAB16123" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10044" /db_xref="UniProtKB/Swiss-Prot:P37516" /translation="MQIEHTAVWVNDLERMKSFYESYFNGEANDLYHNEKKDFKSYFI TFDSGARLEIMKKGNVTDPPSQTMTGWAHIAFSVGSREKVDELTDRLKADGFAVVNGP RTTGDGYYESVIEDDEGNLIEITI*" /label="yyaH CDS" gene complement(3645664..3646044) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /label="yyaH gene" CDS complement(3646100..3647035) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9457849, 9642180, 16267306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457849, 9642180, 16267306; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of carbon supply (LacIfamily)" /protein_id="NP_391967.1" /db_xref="EnsemblGenomes-Gn:BSU40870" /db_xref="EnsemblGenomes-Tr:CAB16124" /db_xref="GOA:P37517" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10045" /db_xref="UniProtKB/Swiss-Prot:P37517" /translation="MANIKEIARLANVSVSTVSRVLNHHPYVSEEKRKLVHQVMKELD YTPNRTAIDLIRGKTHTVGVILPYSDHPCFDKIVNGITKAAFQHEYATTLLPTNYNPD IEIKYLELLRTKKIDGLIITSRANHWDSILAYQEYGPVIACEDTGDIDVPCAFNDRKT AYAESFRYLKSRGHENIAFTCVREADRSPSTADKAAAYKAVCGRLEDRHMLSGCNDMN DGELAAEHFYMSGRVPTAIYANSDEVAAGIHLFAKKNNWDVEIIGEGNTSISRVLGFP SLDLNLEQLGIAAFSLFLQDEPADIKIQHKFKKKA*" /label="ccpB CDS" gene complement(3646100..3647035) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /label="ccpB gene" promotor_-35 3647025..3647034 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3647048..3647067 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3647055 /Source="Nicolas_upshifts" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3647079..3647098) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3647093) /Source="Nicolas_upshifts" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3647094..3647852) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /EC_number="3.1.11.2" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10540738, 16237020, 18203828, 21441501, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10540738, 16237020, 18203828, 21441501, 24244006, 24914186; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="apurinic/apyrimidinic endonuclease" /protein_id="NP_391968.1" /db_xref="EnsemblGenomes-Gn:BSU40880" /db_xref="EnsemblGenomes-Tr:CAB16125" /db_xref="GOA:P37454" /db_xref="InterPro:IPR004808" /db_xref="InterPro:IPR005135" /db_xref="InterPro:IPR020847" /db_xref="InterPro:IPR020848" /db_xref="InterPro:IPR036691" /db_xref="PDB:5CFE" /db_xref="SubtiList:BG10046" /db_xref="UniProtKB/Swiss-Prot:P37454" /translation="MKLISWNVNGLRAVMRKMDFLSYLKEEDADIICLQETKIQDGQV DLQPEDYHVYWNYAVKKGYSGTAVFSKQEPLQVIYGIGVEEHDQEGRVITLEFENVFV MTVYTPNSRRGLERIDYRMQWEEALLSYILELDQKKPVILCGDLNVAHQEIDLKNPKA NRNNAGFSDQEREAFTRFLEAGFVDSFRHVYPDLEGAYSWWSYRAGARDRNIGWRIDY FVVSESLKEQIEDASISADVMGSDHCPVELIINI*" /label="exoA CDS" gene complement(3647094..3647852) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /label="exoA gene" promotor_-35 complement(3647111..3647118) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3647385..3647888 /Source="Nicolas_S_feature" /locus_tag="new_4198071_4198574" /HighExp="C30, S8, S7, S6, BT, S5, M/G, Glucon, C90, T1.0H" /AntisenseName="exoAA" /AntisenseCor="-0.177921457862244" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1574" downshifts 3647847 /Source="Nicolas_upshifts" /id="D2118" /incds=0 /nref=2 /ntot=12 /MaxReadThrough="2.65789" /MaxDrop="4.11352" /score="16.4680636" /energy="-6.8" /TU="NA" /idTUdmin="U3224" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS complement(3647917..3648156) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 22720735, 24310371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 22720735, 24310371; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S18" /protein_id="NP_391969.2" /db_xref="EnsemblGenomes-Gn:BSU40890" /db_xref="EnsemblGenomes-Tr:CAB16126" /db_xref="GOA:P21475" /db_xref="InterPro:IPR001648" /db_xref="InterPro:IPR018275" /db_xref="InterPro:IPR036870" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10047" /db_xref="UniProtKB/Swiss-Prot:P21475" /translation="MAGGRRGGRAKRRKVCYFTSNGITHIDYKDVDLLKKFVSERGKI LPRRVTGTNAKYQRKLTAAIKRARQMALLPYVSGE*" /label="rpsR CDS" gene complement(3647917..3648156) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /label="rpsR gene" downshifts complement(3647923) /Source="Nicolas_upshifts" /id="D2119" /incds=0 /nref=217 /ntot=268 /MaxReadThrough="4.97781" /MaxDrop="7.46952" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227" /idTUdmin="U3229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3647991) /Source="Nicolas_upshifts" /id="D2120" /incds=1 /nref=13 /ntot=142 /MaxReadThrough="8.89363" /MaxDrop="3.9797" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227,U3229" /idTUdmin="U3229" /TUdmin="-68" /isTUend="FALSE" /label="downshifts" CDS complement(3648200..3648718) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391970.1" /db_xref="EnsemblGenomes-Gn:BSU40900" /db_xref="EnsemblGenomes-Tr:CAB16127" /db_xref="GOA:P37455" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10048" /db_xref="UniProtKB/Swiss-Prot:P37455" /translation="MLNRVVLVGRLTKDPELRYTPNGAAVATFTLAVNRTFTNQSGER EADFINCVTWRRQAENVANFLKKGSLAGVDGRLQTRNYENQQGQRVFVTEVQAESVQF LEPKNGGGSGSGGYNEGNSGGGQYFGGGQNDNPFGGNQNNQRRNQGNSFNDDPFANDG KPIDISDDDLPF*" /label="ssbA CDS" gene complement(3648200..3648718) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /label="ssbA gene" CDS complement(3648759..3649046) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 19653700, 26447183" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 19653700, 26447183; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S6 (BS9)" /protein_id="NP_391971.1" /db_xref="EnsemblGenomes-Gn:BSU40910" /db_xref="EnsemblGenomes-Tr:CAB16128" /db_xref="GOA:P21468" /db_xref="InterPro:IPR000529" /db_xref="InterPro:IPR014717" /db_xref="InterPro:IPR020814" /db_xref="InterPro:IPR020815" /db_xref="InterPro:IPR035980" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10049" /db_xref="UniProtKB/Swiss-Prot:P21468" /translation="MRKYEVMYIIRPNIDEESKKAVIERFNNVLTSNGAEITGTKDWG KRRLAYEINDFRDGFYQIVNVQSDAAAVQEFDRLAKISDDIIRHIVVKEEE*" /label="rpsF CDS" gene complement(3648759..3649046) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /label="rpsF gene" S_feature complement(3649047..3649113) /Source="Nicolas_S_feature" /locus_tag="new_4199733_4199799_c" /HighExp="MG t5, LPhT, GM 90, SMM, T-5.40H, GM-0.2, MG 150, GM 45, Gly, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.993, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1575" promotor_-10 complement(3649112..3649131) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3649113) /Source="Nicolas_upshifts" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3649145..3649150) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3649157..3650257) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12837776, 16014871, 18713637, 21527254, 22995830, 26018081, 26160547, 26912459; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent informational ATPase interacting with 70S ribosome; ROS stress regulator" /protein_id="NP_391972.1" /db_xref="EnsemblGenomes-Gn:BSU40920" /db_xref="EnsemblGenomes-Tr:CAB16129" /db_xref="GOA:P37518" /db_xref="InterPro:IPR004396" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR013029" /db_xref="InterPro:IPR023192" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="SubtiList:BG10050" /db_xref="UniProtKB/Swiss-Prot:P37518" /translation="MALTAGIVGLPNVGKSTLFNAITQAGAESANYPFCTIDPNVGIV EVPDDRLQKLTELVNPKKTVPTAFEFTDIAGIVKGASKGEGLGNKFLSHIRQVDAICH VVRAFSDDNITHVSGKVDPIDDIETINLELILADMETVEKRITRVSKLAKQKDKDAVF EFEILSKLKEAFESEKPARSVEFTEEQQKLVKQLHLLTSKPILYVANVSEDEVADPSG NENVAKIREYAAGENAEVIVVCAKIESEIAELEGEEKQMFLEELGIQESGLDQLIKAS YSLLGLATYFTAGEQEVRAWTFKKGMKAPECAGIIHSDFERGFIRAETVAYEDLLAGG GMAGAKEAGKVRLEGKEYVVQDGDVIHFRFNV*" /label="engD CDS" gene complement(3649157..3650257) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /label="engD gene" promotor_-10 complement(3650305..3650324) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-10" upshifts complement(3650320) /Source="Nicolas_upshifts" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="upshifts" promotor_-35 complement(3650339..3650346) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-35" CDS complement(3650384..3652387) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /EC_number="1.-.-.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17114254, 20817769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (molybdoenzyme)" /protein_id="NP_391973.1" /db_xref="EnsemblGenomes-Gn:BSU40930" /db_xref="EnsemblGenomes-Tr:CAB16130" /db_xref="GOA:P37519" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG10051" /db_xref="UniProtKB/Swiss-Prot:P37519" /translation="MSKVHQSACPLNCWDSCGFLVTVDDGKVTKVDGDPNHPITEGKI CGRGRMLETKTNSPDRLRYPMKKQNGEFVRISWEQALDEIADKLREIKETSETTAVLH SHDYANNGLLKALDQRFFNGYGGVTEIVGSICWGSGIEAQSWDFGRSYGHGPLDIYNS KHVVVWGRNVSRTNMHLYHHLQQVKKKGATITVIDPIFNPTAKLADRYISVKPGMDGW LAAAVLKVLIEMGRTDETFISEHSVGFDDVKELLKTVSLEEFIVKTETSMEELEYLAG LYADGPVSTFMGLGMQRYKNGGGTIRWIDALVAASGNVGIKGGGANFGNVQIGESFAK TKLTLPELKTTSRSFSMMTQAEEVLTAADPAIEMIIVTCGNPLTQVPNTNKVRQAFEK VPMTVAIDSIMTDTAELCDYVLPTATVFEEEDIYYSSMYHHYVQYGKKLVEPQGEAKS DSWIWSELAKRLGFGELFEYSTQEFLEMGLSSLEAEDVTLERLKEKGHLPLPVKQVPW DDYQFLTPSGKFEFTSSLAEQKGFSGSLQLNVPEESVFHNEELAGKYPYTLLSIHPQR SNHSQHVPFIEKLQHVQVDISPDIAAGQDLQDGDEVVIFNDRGSMKGKVKVMKQAHAK TINIDEGMWAAFGGSVNALTNDTNSDNGMGSTLFDCLVGLKKA*" /label="yyaE CDS" gene complement(3650384..3652387) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /label="yyaE gene" CDS complement(3652438..3652644) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21348639, 22333191, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="YP_003097803.1" /db_xref="EnsemblGenomes-Gn:BSU40939" /db_xref="EnsemblGenomes-Tr:CAX52723" /db_xref="InterPro:IPR009296" /db_xref="UniProtKB/Swiss-Prot:C0H3V8" /translation="MADKDFGLNDIVEMKKPHPCGANSWKIIRMGMDIRIKCEGCSHS VMIPRREFERKLKKVLVKHEEPTS*" /label="yyzM CDS" gene complement(3652438..3652644) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /label="yyzM gene" promotor_-10 complement(3652606..3652625) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3652631) /Source="Nicolas_upshifts" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3652640..3652646) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3652670..3652689) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-10" upshifts complement(3652681) /Source="Nicolas_upshifts" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="upshifts" promotor_-35 complement(3652706..3652710) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-35" CDS complement(3652738..3653754) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16847258, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391974.1" /db_xref="EnsemblGenomes-Gn:BSU40940" /db_xref="EnsemblGenomes-Tr:CAB16131" /db_xref="SubtiList:BG10052" /db_xref="UniProtKB/Swiss-Prot:P37520" /translation="MLWRAGMKWMLLILGSLIGAGYASGQEIWQFFGAESGLAIVLFT IMFIFSSYIVMKISFKVQSTHFLPVLEHLMGPWLAKIYDVLIIFYLFSTTMVMIAGGG VTLQMYKLPFWWGITLICIVTVCLFLWDVKGILSINSILIPVLVAGLLYALISFQSTH HHTWTIDLSQQYNWPASITFTSLNILSVVAILSSVGKEMKGLGEAKIASVASGLIFGV ISFVYNETLVELAGSLSQFEIPLFAVLEGAPYFLFLCMTAVLCLAIYTTTVAGLLGLS SRLMAFIHMPRWMIVLILLVLMVPFTSFGFSDLIAFLYPIYGMLNLYLLVCLLLYPIL SKWK*" /label="yyaD CDS" gene complement(3652738..3653754) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /label="yyaD gene" promotor_-10 complement(3653787..3653805) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3653799) /Source="Nicolas_upshifts" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3653821..3653826) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3653930) /Source="Nicolas_upshifts" /id="D2121" /incds=0 /nref=32 /ntot=184 /MaxReadThrough="1.8976" /MaxDrop="3.72136" /score="9.09987016" /energy="-7.4" /TU="NA" /idTUdmin="U3230" /TUdmin="-397" /isTUend="FALSE" /label="downshifts" promotor_-35 3654114..3654119 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3654132..3654213 /Source="Nicolas_S_feature" /locus_tag="new_4204818_4204899" /HighExp="S4, S5, S3, S6, LoTm, S7, T5.0H, BT, M9-stat, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1576" upshifts 3654132 /Source="Nicolas_upshifts" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3654135..3654153 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3654214..3654831 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 26362088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore-specific protease" /protein_id="NP_391975.1" /db_xref="EnsemblGenomes-Gn:BSU40950" /db_xref="EnsemblGenomes-Tr:CAB16132" /db_xref="InterPro:IPR009665" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10053" /db_xref="UniProtKB/Swiss-Prot:P37521" /translation="MNRKGGLFSSQERVKQYVSHTDAAAAKQIQTILSSSLRKAAGKP IVVVCIGTDRSTGDSLGPLVGMKLKQMQLTRFHVYGTLSDPVHAVNMKDKINDIHKLH KNPFVIAVDACLGRVKSVGSFQIGDGPLKPGAGVQKDLPEVGDLHINGIVNVSGFMEY FVLQNTRLNLVMNMANVLAEGLSLTDRTEWRQERLNPLQRLTGRI*" /label="sprC CDS" gene 3654214..3654831 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /label="sprC gene" promotor_-35 3654802..3654810 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3654821 /Source="Nicolas_upshifts" /id="D2122" /incds=0 /nref=11 /ntot=30 /MaxReadThrough="2.64888" /MaxDrop="3.74502" /score="0.352922387" /energy="-6.6" /TU="NA" /idTUdmin="U3231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 3654824..3654842 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3654843 /Source="Nicolas_upshifts" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3654870..3655718) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103; Product type f: factor" /codon_start=1 /transl_table=11 /product="site-specific DNA-binding protein" /protein_id="NP_391976.1" /db_xref="EnsemblGenomes-Gn:BSU40960" /db_xref="EnsemblGenomes-Tr:CAB16133" /db_xref="GOA:P26497" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10054" /db_xref="UniProtKB/Swiss-Prot:P26497" /translation="MAKGLGKGINALFNQVDLSEETVEEIKIADLRPNPYQPRKHFDD EALAELKESVLQHGILQPLIVRKSLKGYDIVAGERRFRAAKLAGLDTVPAIVRELSEA LMREIALLENLQREDLSPLEEAQAYDSLLKHLDLTQEQLAKRLGKSRPHIANHLRLLT LPENIQQLIAEGTLSMGHGRTLLGLKNKNKLEPLVQKVIAEQLNVRQLEQLIQQLNQN VPRETKKKEPVKDAVLKERESYLQNYFGTTVNIKRQKKKGKIEIEFFSNEDLDRILEL LSERES*" /label="parB CDS" gene complement(3654870..3655718) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /label="parB gene" downshifts complement(3654890) /Source="Nicolas_upshifts" /id="D2123" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="3.01094" /MaxDrop="5.3801" /score="9.82080496" /energy="-7.9" /TU="U3233" /idTUdmin="U3233" /TUdmin="-257" /isTUend="FALSE" /label="downshifts" CDS complement(3655711..3656472) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome partitioning protein; transcriptionalregulator" /protein_id="NP_391977.1" /db_xref="EnsemblGenomes-Gn:BSU40970" /db_xref="EnsemblGenomes-Tr:CAB16134" /db_xref="GOA:P37522" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10055" /db_xref="UniProtKB/Swiss-Prot:P37522" /translation="MGKIIAITNQKGGVGKTTTSVNLGACLAYIGKRVLLVDIDPQGN ATSGLGIEKADVEQCVYDILVDDADVIDIIKATTVENLDVIPATIQLAGAEIELVPTI SREVRLKRALEAVKQNYDYIIIDCPPSLGLLTINALTASDSVVIPVQCEYYALEGLSQ LLNTVRLVQKHLNTDLMIEGVLLTMLDARTNLGIQVIEEVKKYFRDKVYKTVIPRNVR LSEAPSHGKPIILYDPRSRGAEVYLDLAKEVAANG*" /label="parA CDS" gene complement(3655711..3656472) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /label="parA gene" misc_feature complement(3656506..3656525) /Source="Nicolas_upshift_promotors" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3656524) /Source="Nicolas_upshifts" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3656616) /Source="Nicolas_upshifts" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="upshifts" promotor_-10 complement(3656619..3656627) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-10" promotor_-35 complement(3656641..3656649) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-35" promotor_-35 3656653..3656661 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3656669 /Source="Nicolas_upshifts" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3656673..3656691 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3656720..3657160 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25651892; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative antibiotic immunity protein" /protein_id="NP_391978.2" /db_xref="EnsemblGenomes-Gn:BSU40980" /db_xref="EnsemblGenomes-Tr:CAB16135" /db_xref="GOA:P37523" /db_xref="InterPro:IPR009589" /db_xref="SubtiList:BG10056" /db_xref="UniProtKB/Swiss-Prot:P37523" /translation="MVYQTKRDVPVTLMIVFLILLIQADAIVPFVLGNMRVSGWIIFI LLTLLNGLIIWSFIDLKYVLKEHHLIIKAGLIKHQIPYENIDKVVQKKKLWSGFRLIG SRHAITIYYQGGWGHAVISPQKSEEFIHKLKEKNSNIIIFTKSK*" /label="yyaB CDS" gene 3656720..3657160 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /label="yyaB gene" downshifts 3657109 /Source="Nicolas_upshifts" /id="D2124" /incds=0 /nref=3 /ntot=144 /MaxReadThrough="2.25356" /MaxDrop="3.41185" /score="-0.6683508" /energy="-14.5" /TU="NA" /idTUdmin="U3235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3657211..3658062) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /function="16.13: Shape" /function="16.8: Protect" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11807071, 15210112, 16549676, 25568309, 28500529" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807071, 15210112, 16549676, 25568309, 28500529; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-binding protein Spo0J-like" /protein_id="NP_391979.1" /db_xref="EnsemblGenomes-Gn:BSU40990" /db_xref="EnsemblGenomes-Tr:CAB16136" /db_xref="GOA:P37524" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR023705" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10057" /db_xref="UniProtKB/Swiss-Prot:P37524" /translation="MKHSFSRFFGLGEKEQEPEIAEHDTNKEEILEIPVNAIVPNRFQ PRTIFSDEKIKELAMTIHTHGIIQPIVVRHTEEEGQYELIAGERRWRAVQSLEWEKIP AIIKDFSDTETASVALIENLQREELSSIEEAHAYARLLELHDLTQEALAQRLGKGQST IANKLRLLKLPQPVQEAIMEKKITERHARALIPLKQPELQVTLLTEIIEKSLNVKQTE DRVVKMLEQGQRKPKPRRKAFSRDTRIAMNTIRQSLSMVEDSGVKLNTEEEEFEEYIQ LTIRIPK*" /label="nocA CDS" gene complement(3657211..3658062) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /label="nocA gene" downshifts complement(3657230) /Source="Nicolas_upshifts" /id="D2125" /incds=0 /nref=245 /ntot=265 /MaxReadThrough="2.30868" /MaxDrop="6.68899" /score="29.5496038" /energy="-14.5" /TU="NA" /idTUdmin="U3236" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(3658063..3658183) /Source="Nicolas_S_feature" /locus_tag="new_4208749_4208869_c" /HighExp="LBGstat, G135, G180, H2O2, dia15, G150, Paraq, T0.30H, Oxctl, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1577" CDS complement(3658184..3658903) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /EC_number="2.1.1.170" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12001236, 17238915, 17573471, 19622680, 24509311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12001236, 17238915, 17573471, 19622680, 24509311; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-methylguanosine methyltransferase (16S rRNA, nucleotide G527)" /protein_id="NP_391980.1" /db_xref="EnsemblGenomes-Gn:BSU41000" /db_xref="EnsemblGenomes-Tr:CAB16137" /db_xref="GOA:P25813" /db_xref="InterPro:IPR003682" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XDZ" /db_xref="SubtiList:BG10058" /db_xref="UniProtKB/Swiss-Prot:P25813" /translation="MNIEEFTSGLAEKGISLSPRQLEQFELYYDMLVEWNEKINLTSI TEKKEVYLKHFYDSITAAFYVDFNQVNTICDVGAGAGFPSLPIKICFPHLHVTIVDSL NKRITFLEKLSEALQLENTTFCHDRAETFGQRKDVRESYDIVTARAVARLSVLSELCL PLVKKNGLFVALKAASAEEELNAGKKAITTLGGELENIHSFKLPIEESDRNIMVIRKI KNTPKKYPRKPGTPNKSPIEG*" /label="rsmG CDS" gene complement(3658184..3658903) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /label="rsmG gene" CDS complement(3658917..3660803) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11914360, 14993678, 17062623, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA uridine 5-carboxymethylaminomethyl modification enzyme" /protein_id="NP_391981.1" /db_xref="EnsemblGenomes-Gn:BSU41010" /db_xref="EnsemblGenomes-Tr:CAB16138" /db_xref="GOA:P25812" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004416" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR026904" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10059" /db_xref="UniProtKB/Swiss-Prot:P25812" /translation="MGYEAGQYDVIVIGAGHAGVEAALASARQGAKTLVLTINLDMVA FMPCNPSVGGPAKGIVVREIDALGGEMGRNIDKTHIQMRMLNTGKGPAVRALRAQADK FQYQHEMKNTLEKEPNLTLLQGIVERLIVEDGECRGVITQTGAHYRAKAVVMTTGTYL RGRIILGDLSYSSGPNNQQPSIKLSEHLEELGFDLVRFKTGTPPRVKSDTIDYSKTEI QPGDDVPRAFSYETVEYITDQLPCWLTYTSPETHEIIDSNLHRSPMYSGMIKGTGPRY CPSIEDKVVRFNDKPRHQIFLEPEGRNTQEVYVQGLSTSLPEDVQQRMLATIPGLENV QMMRAGYAIEYDAIVPTQLWPTLETKKITNLYTAGQINGTSGYEEAAGQGIMAGINAG RKALGKEEVILSRSDAYIGVLIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTE IGHRIGLISDERYAAFEKKKAAIEAEKKRLHSVIIKPSPENQEYIRSLGGSELKDGVR GTDLMKRPEMNYETVTKLAPPEVPVPQDVAEQVEIQVKYEGYIEKSLQQVEKLKKMEN KKIPDRIDYDAIKGIATEARQKLKNVRPLSVAQASRISGVNPADISILLVYLEQGRIA KIAE*" /label="trmF CDS" gene complement(3658917..3660803) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /label="trmF gene" CDS complement(3660824..3662203) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /EC_number="3.6.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15522079, 15616586, 19052377, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA modification GTPase and tRNA-U34 5-formylation enzyme" /protein_id="NP_391982.1" /db_xref="EnsemblGenomes-Gn:BSU41020" /db_xref="EnsemblGenomes-Tr:CAB16139" /db_xref="GOA:P25811" /db_xref="InterPro:IPR004520" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR018948" /db_xref="InterPro:IPR025867" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031168" /db_xref="SubtiList:BG10060" /db_xref="UniProtKB/Swiss-Prot:P25811" /translation="MDTIAAISTPMGEGAIAIVRLSGPEAIQIADKIYKGPKGKTLSS VESHTIHYGHIVDRPSDRVVEEVMVSVLKAPRTFTREDVIEINCHGGIVTVNQVLQLA LREGARLAEPGEFTKRAFLNGRIDLSQAEAVMDLIRAKTDRAMNVAMNQMEGRLSALV RRLRSEILETLAHVEVNIDYPEYDDVEEMTHQILVEKATAVKKEIETLLRTSEQGKIL REGLSTVIIGRPNVGKSSLLNSLVHEAKAIVTDIPGTTRDVIEEYVNVRGVPLRLVDT AGIRETEDIVERIGVERSRQVLKEADLILLVLNYSEELSEEDVKLFEAVEGMDVIVIL NKTDLEPKIDTERVRELANGRPVVTTSLLKEEGINDLEEAIQSLFYTGAIESGDLTYV SNTRHITILQQAKRAIEDALSGIEQDVPIDMVQIDLTRCWELLGEIIGDSVHESLIDQ LFSQFCLGK*" /label="mnmE CDS" gene complement(3660824..3662203) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /label="mnmE gene" S_feature complement(3662204..3662334) /Source="Nicolas_S_feature" /locus_tag="new_4212890_4213020_c" /HighExp="dia15, Diami, LBGstat, H2O2, Paraq, dia5, G180, T0.30H, LBGexp, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1578" promotor_-10 complement(3662326..3662345) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3662334) /Source="Nicolas_upshifts" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3662361..3662365) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3662389..3662408) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-10" upshifts complement(3662399) /Source="Nicolas_upshifts" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="upshifts" promotor_-35 complement(3662422..3662429) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-35" promotor_-35 3662489..3662495 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3662500..3664785 /Source="Nicolas_S_feature" /locus_tag="new_4213186_4215471" /HighExp="T0.30H, C30, T1.0H, T1.30H, S2, T0.0H, T-1.10H, T-0.40H, T-1.40H, C90" /AntisenseName="oxaAA" /AntisenseCor="-0.20593684080740801" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.685" /TUlongSig="NA" /TUlongPSig="NA" /label="S1579" upshifts 3662500 /Source="Nicolas_upshifts" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3662510..3662529 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3662514..3663140) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1487728, 12813085, 26883633, 27776484; Product type f: factor" /codon_start=1 /transl_table=11 /product="SpoIIIJ-associated RNA/ssDNA-binding protein" /protein_id="NP_391983.1" /db_xref="EnsemblGenomes-Gn:BSU41030" /db_xref="EnsemblGenomes-Tr:CAB16140" /db_xref="GOA:Q01620" /db_xref="InterPro:IPR001374" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR032782" /db_xref="InterPro:IPR034079" /db_xref="InterPro:IPR036867" /db_xref="SubtiList:BG10061" /db_xref="UniProtKB/Swiss-Prot:Q01620" /translation="MRNVTAAGRNVDEAVQSGLQELGLTKDKVEITVIEEGNKGFLGI FGKKPAIVKLVEKIDPIQQAKLYLQTIAEAIAGKSDVTVQESKKTVRYHITGEKAALL IGKRGQTLNALETLTQLALNRYPGQYKNVTVDAENYRLKRKETLSQLAIKLADQVLKT KKSIQLEPMPSSERKIIHDTLSGYANHQIKTYSMGEGENRHLVISHKR*" /label="jag CDS" gene complement(3662514..3663140) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /label="jag gene" downshifts complement(3662531) /Source="Nicolas_upshifts" /id="D2126" /incds=0 /nref=229 /ntot=258 /MaxReadThrough="2.29192" /MaxDrop="6.32351" /score="24.2602773" /energy="-14.1" /TU="NA" /idTUdmin="U3239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3663137..3663922) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_391984.1" /db_xref="EnsemblGenomes-Gn:BSU41040" /db_xref="EnsemblGenomes-Tr:CAB16141" /db_xref="GOA:Q01625" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG10062" /db_xref="UniProtKB/Swiss-Prot:Q01625" /translation="MLLKRRIGLLLSMVGVFMLLAGCSSVKEPITADSPHFWDKYVVY PLSELITYVAKLTGDNYGLSIILVTILIRLLILPLMIKQLRSSKAMQALQPEMQKLKE KYSSKDQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEH SFLWFDLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAI NFPAALSLYWVVGNLFMIAQTFLIKGPDIKKNPEPQKAGGKKK*" /label="oxaAA CDS" gene complement(3663137..3663922) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /label="oxaAA gene" promotor_-10 complement(3663967..3663986) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3663979) /Source="Nicolas_upshifts" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3663981..3664066) /Source="Nicolas_S_feature" /locus_tag="new_4214667_4214752_c" /HighExp="G135, G180, H2O2, Oxctl, Paraq, G150, Cold, LPh, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1580" promotor_-35 complement(3663998..3664004) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3664067..3664417) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /EC_number="3.1.26.5" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16061811, 16163391, 16980484, 17299131, 21347352, 24580115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein component of ribonuclease P (RNase P) (substrate specificity)" /protein_id="NP_391985.1" /db_xref="EnsemblGenomes-Gn:BSU41050" /db_xref="EnsemblGenomes-Tr:CAB16142" /db_xref="GOA:P25814" /db_xref="InterPro:IPR000100" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020539" /db_xref="InterPro:IPR020568" /db_xref="PDB:1A6F" /db_xref="PDB:4JG4" /db_xref="SubtiList:BG10063" /db_xref="UniProtKB/Swiss-Prot:P25814" /translation="MKKRNRLKKNEDFQKVFKHGTSVANRQFVLYTLDQPENDELRVG LSVSKKIGNAVMRNRIKRLIRQAFLEEKERLKEKDYIIIARKPASQLTYEETKKSLQH LFRKSSLYKKSSSK*" /label="rnpA CDS" gene complement(3664067..3664417) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /label="rnpA gene" S_feature complement(3664418..3664568) /Source="Nicolas_S_feature" /locus_tag="new_4215104_4215254_c" /HighExp="G135, G180, Oxctl, H2O2, Paraq, Cold, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1581" CDS complement(3664569..3664703) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7539334, 9371771, 12682299, 23002217, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7539334, 9371771, 12682299, 23002217, 25182490; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L34" /protein_id="NP_391986.1" /db_xref="EnsemblGenomes-Gn:BSU41060" /db_xref="EnsemblGenomes-Tr:CAB16143" /db_xref="GOA:P05647" /db_xref="InterPro:IPR000271" /db_xref="InterPro:IPR020939" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10064" /db_xref="UniProtKB/Swiss-Prot:P05647" /translation="MKRTFQPNNRKRSKVHGFRSRMSSKNGRLVLARRRRKGRKVLSA *" /label="rpmH CDS" gene complement(3664569..3664703) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /label="rpmH gene" promotor_no_box 3664727..3664827 /Source="Nicolas_upshift_promotors" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(3664739..3664758) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3664749) /Source="Nicolas_upshifts" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3664751..3664819) /Source="Nicolas_S_feature" /locus_tag="new_4215437_4215505_c" /HighExp="Oxctl, G180, Paraq, H2O2, LBGstat, GM 120, MG-0.2, HPh, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1582" promotor_-35 complement(3664774..3664781) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3664787..>3664920 /Source="Nicolas_S_feature" /locus_tag="new_4215473_4215670" /HighExp="T0.30H, C30, T1.0H, T1.30H, T0.0H, T-0.40H, S2, T-1.10H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.048" /TUlongSig="NA" /TUlongPSig="NA" /label="S1583" upshifts 3664787 /Source="Nicolas_upshifts" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3664805..3664824) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3664819) /Source="Nicolas_upshifts" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3664840..3664844) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3664921..3665068 /locus_tag="new_1_148" /created_by="stephanmichalik" /label="S1" S_feature complement(3664944..3665217) /locus_tag="new_24_297_c" /created_by="stephanmichalik" /label="S2" S_feature 3665070..3665329 /locus_tag="new_150_409" /created_by="stephanmichalik" /label="S3" ORIGIN 1 atggaaaata tattagacct gtggaaccaa gcccttgctc aaatcgaaaa aaagttgagc 61 aaaccgagtt ttgagacttg gatgaagtca accaaagccc actcactgca aggcgataca 121 ttaacaatca cggctcccaa tgaatttgcc agagactggc tggagtccag atacttgcat 181 ctgattgcag atactatata tgaattaacc ggggaagaat tgagcattaa gtttgtcatt 241 cctcaaaatc aagatgttga ggactttatg ccgaaaccgc aagtcaaaaa agcggtcaaa 301 gaagatacat ctgattttcc tcaaaatatg ctcaatccaa aatatacttt tgatactttt 361 gtcatcggat ctggaaaccg atttgcacat gctgcttccc tcgcagtagc ggaagcgccc 421 gcgaaagctt acaacccttt atttatctat gggggcgtcg gcttagggaa aacacactta 481 atgcatgcga tcggccatta tgtaatagat cataatcctt ctgccaaagt ggtttatctg 541 tcttctgaga aatttacaaa cgaattcatc aactctatcc gagataataa agccgtcgac 601 ttccgcaatc gctatcgaaa tgttgatgtg cttttgatag atgatattca atttttagcg 661 gggaaagaac aaacccagga agaatttttc catacattta acacattaca cgaagaaagc 721 aaacaaatcg tcatttcaag tgaccggccg ccaaaggaaa ttccgacact tgaagacaga 781 ttgcgctcac gttttgaatg gggacttatt acagatatca caccgcctga tctagaaacg 841 agaattgcaa ttttaagaaa aaaggccaaa gcagagggcc tcgatattcc gaacgaggtt 901 atgctttaca tcgcgaatca aatcgacagc aatattcggg aactcgaagg agcattaatc 961 agagttgtcg cttattcatc tttaattaat aaagatatta atgctgatct ggccgctgag 1021 gcgttgaaag atattattcc ttcctcaaaa ccgaaagtca ttacgataaa agaaattcag 1081 agggtagtag gccagcaatt taatattaaa ctcgaggatt tcaaagcaaa aaaacggaca 1141 aagtcagtag cttttccgcg tcaaatcgcc atgtacttat caagggaaat gactgattcc 1201 tctcttccta aaatcggtga agagtttgga ggacgtgatc atacgaccgt tattcatgcg 1261 catgaaaaaa tttcaaaact gctggcagat gatgaacagc ttcagcagca tgtaaaagaa 1321 attaaagaac agcttaaata gcaggaccgg ggatcaatcg gggaaagtgt gaataacttt 1381 tcggaagtca tacacagtct gtccacatgt ggataggctg tgtttcctgt ctttttcaca 1441 acttatccac aaatccacag gccctactat tacttctact attttttata aatatatata 1501 ttaatacatt atccgttagg aggataaaaa tgaaattcac gattcaaaaa gatcgtcttg 1561 ttgaaagtgt ccaagatgta ttaaaagcag tttcatccag aaccacgatt cccattctga 1621 ctggtattaa aattgttgca tcagatgatg gagtatcctt tacagggagt gactcagata 1681 tttctattga atccttcatt ccaaaagaag aaggagataa agaaatcgtc actattgaac 1741 agcccggaag catcgtttta caggctcgct tttttagtga aattgtaaaa aaattgccga 1801 tggcaactgt agaaattgaa gtccaaaatc agtatttgac gattatccgt tctggtaaag 1861 ctgaatttaa tctaaacgga ctggatgctg atgaatatcc gcacttgccg cagattgaag 1921 agcatcatgc gattcagatc ccaactgatt tgttaaaaaa tctaatcaga caaacagtat 1981 ttgcagtgtc cacctcagaa acacgcccta tcttgacagg tgtaaactgg aaagtggagc 2041 aaagtgaatt attatgcact gcaacggata gccaccgtct tgcattaaga aaggcgaaac 2101 ttgatattcc agaagacaga tcttataacg tcgtgattcc gggaaaaagt ttaactgaac 2161 tcagcaagat tttagatgac aaccaggaac ttgtagatat cgtcatcaca gaaacccaag 2221 ttctgtttaa agcgaaaaac gtcttgttct tctcacggct tctggacggg aattatccag 2281 acacaaccag cctgattccg caagacagca aaacagaaat cattgtgaac acaaaagaat 2341 tccttcaggc cattgatcgt gcatctcttt tagctagaga gggacgcaac aacgttgtaa 2401 aactgtccgc aaaaccggct gaatccattg aaatttcttc caattcgcca gaaatcggta 2461 aagttgtgga agcaattgtt gcggatcaaa ttgaaggtga ggaattaaat atctctttta 2521 gtccaaaata tatgctggat gcactaaagg tgcttgaagg agcagaaata cgcgtaagct 2581 ttacaggcgc aatgagacct ttcttaattc gcacgccgaa tgatgaaacg attgtacagc 2641 ttatccttcc tgtcagaacc tattaatccg atacactgct gccgacccgt cggcagcttt 2701 tctattcggt atctgctccg acaagttttc cctttcccta attcgttttt ttttagtaca 2761 attagatatt agtgatattt gaaagaggtc gatataatgg caaatccgat ttcaattgat 2821 acagagatga ttacactcgg acaattctta aaattagccg atgtgattca gtctggcggt 2881 atggcgaagt ggtttttaag cgagcatgaa gtgcttgtga acgatgagcc ggacaaccgc 2941 cggggcagaa agctgtatgt tggagatgtg gtagagattg aaggatttgg ttcatttcaa 3001 gtcgtcaatt aaagcgggtg acactgattg tatatccaga acttagaact gacatcttac 3061 cgcaactacg accatgctga acttcaattt gaaaataaag taaatgtgat catcggagaa 3121 aacgcccagg ggaagacaaa cctcatggag gcgatctatg tcttgtccat ggcgaaatcg 3181 caccggacat caaatgacaa agaacttata cggtgggaca aagactatgc taaaatagag 3241 ggaagagtga tgaagcaaaa cggggcgatc ccgatgcagc tcgtcatctc caaaaagggt 3301 aaaaagggca aggtcaatca tattgaacag caaaagctca gccagtatgt cggggccctc 3361 aacaccatta tgttcgcgcc ggaagattta aatcttgtaa agggaagccc tcaagtgaga 3421 aggcggtttc ttgacatgga aatcggacag gtttctcccg tctaccttca tgatctttct 3481 ctttaccaga aaatcctttc ccagcggaat cattttttga aacagctgca aacaagaaaa 3541 caaactgacc ggacgatgct cgatgttctg accgatcagc ttgtagaagt tgcagcaaaa 3601 gtcgtcgtaa aacgcctgca gtttacagca cagctcgaga aatgggcgca gcccatccat 3661 gcaggcatct caagagggct tgaagaactg accctgaaat accatacagc tcttgatgta 3721 tcagatcccc tagatttgtc gaaaatagga gatagctatc aagaagcgtt ttctaaatta 3781 agagaaaaag aaattgagcg tggtgtgacg ctgtcagggc ctcatcgcga tgatgttctt 3841 ttctatgtga acggacgcga tgtgcagacg tatggttctc aaggacagca gcgaacgacg 3901 gcgttgtccc ttaagctggc ggagattgac ctgatccatg aagaaatcgg agaatatccc 3961 attttactat tggatgatgt actgagtgaa ctggatgatt atcgccagtc acacttgctt 4021 catacgatcc aaggccgtgt acaaacgttt gtcacaacga caagcgttga tggcattgat 4081 cacgaaacct tacgtcaagc aggaatgttc cgtgtgcaaa atggtgcgtt agtgaagtga 4141 agaaatgagg tgagcaattg tatattcatt taggtgatga ctttgtggtt tcaacacgag 4201 atattgtcgg catttttgac tttaaagcca acatgtcgcc tattgttgaa gaatttctga 4261 aaaaacagaa acacaaggtg gtgccttccg taaacggcac gcccaaatct atcgtagtca 4321 cggttcagaa tatatattac tctcccttat cttccagcac attaaaaaaa cgtgcgcaat 4381 ttatgtttga aatagattct tagaaatttt ttatcacgaa tatatcgttt agaaaagtgt 4441 aggtgaatga cgtggctatg gaacagcagc aaaacagtta tgatgaaaat cagatacagg 4501 tactagaagg attggaagct gttcgtaaaa gaccggggat gtatatcggt tcgacaaaca 4561 gcaaaggcct tcaccacttg gtatgggaaa ttgtcgacaa tagtattgac gaagccctcg 4621 ccggttattg tacggatatc aatatccaaa tcgaaaaaga caacagtatc acggttgtag 4681 ataatggccg cggtattcca gtcggtattc atgaaaaaat gggccgtcct gcggtagaag 4741 tcattatgac ggtgcttcat gccggaggaa aatttgacgg aagcggctat aaagtatccg 4801 gaggattaca cggtgtaggt gcgtcggtcg taaacgcact atcaacagag cttgatgtga 4861 cggttcaccg tgacggtaaa attcaccgcc aaacctataa acgcggagtt ccggttacag 4921 accttgaaat cattggcgaa acggatcata caggaacgac gacacatttt gtcccggacc 4981 ctgaaatttt ctcagaaaca accgagtatg attacgatct gcttgccaac cgcgtgcgtg 5041 aattagcctt tttaacaaag ggcgtaaaca tcacgattga agataaacgt gaaggacaag 5101 agcgcaaaaa tgaataccat tacgaaggcg gaattaaaag ttatgtagag tatttaaacc 5161 gctctaaaga ggttgtccat gaagagccga tttacattga aggcgaaaag gacggcatta 5221 cggttgaagt ggctttgcaa tacaatgaca gctacacaag caacatttac tcgtttacaa 5281 acaacattaa cacgtacgaa ggcggtaccc atgaagctgg cttcaaaacg ggcctgactc 5341 gtgttatcaa cgattacgcc agaaaaaaag ggcttattaa agaaaatgat ccaaacctaa 5401 gcggagatga cgtaagggaa gggctgacag cgattatttc aatcaaacac cctgatccgc 5461 agtttgaggg ccaaacaaaa acaaagctgg gcaactcaga agcacggacg atcaccgata 5521 cgttattttc tacggcgatg gaaacattta tgctggaaaa tccagatgca gccaaaaaaa 5581 ttgtcgataa aggtttaatg gcggcaagag caagaatggc tgcgaaaaaa gcgcgtgaac 5641 taacacgccg taagagtgct ttggaaattt caaacctgcc cggtaagtta gcggactgct 5701 cttcaaaaga tccgagcatc tccgagttat atatcgtaga gggtgactct gccggaggat 5761 ctgctaaaca aggacgcgac agacatttcc aagccatttt gccgcttaga ggtaaaatcc 5821 taaacgttga aaaggccaga ctggataaaa tcctttctaa caacgaagtt cgctctatga 5881 tcacagcgct cggcacaggt atcggagaag acttcaacct tgagaaagcc cgttaccaca 5941 aagttgtcat tatgacagat gccgatgttg acggcgcgca catcagaaca ctgctgttaa 6001 cgttctttta cagatatatg cgccaaatta tcgaaaatgg ctacgtgtac attgcgcagc 6061 cgccgctcta caaggttcaa caggggaaac gcgttgaata tgcatacaat gacaaggagc 6121 ttgaagagct gttaaaaact cttcctcaaa cgcctaagcc tggactgcag cgttacaaag 6181 gtcttggtga aatgaatgcc acccagctat gggagacaac catggatcct agctccagaa 6241 cacttcttca ggtaactctt gaagatgcaa tggatgcgga tgagactttt gaaatgctta 6301 tgggcgacaa ggtagaaccg cgccgaaact tcatagaagc gaatgcgaga tacgttaaaa 6361 atcttgacat ctaatcataa aaagccttat ttccaataag aaataaggct tttttctgaa 6421 caagatcaga tgcagcgatg cctgcaatac ctatatattc tagcaattta atgtgtataa 6481 tcataagttt attgatataa tggagaatag tgaaatcgta ttgaaggtca taatggacaa 6541 tctactccca catatttcat gtgatacttc agggaggttt tttaatgagt gaacaaaaca 6601 caccacaagt tcgtgaaata aatatcagtc aggaaatgcg tacgtccttc ttggattatg 6661 caatgagcgt tatcgtgtcc cgtgctcttc cggatgttcg tgacggttta aaaccggttc 6721 atagacggat tttgtatgca atgaatgatt taggcatgac aagtgacaag ccttataaaa 6781 aatccgcgcg tatcgttgga gaagttatcg ggaaatacca cccgcacggt gattcagcgg 6841 tatatgaatc catggtcaga atggctcagg atttcaacta ccgttatatg ctcgttgacg 6901 gtcacggaaa cttcggttct gttgacggag actcagcggc ggccatgcgt tatacagaag 6961 cacgaatgtc taaaatctca atggagattc ttcgcgacat cacaaaagac acaatcgatt 7021 accaggataa ctatgacggg tcagaaagag aacctgtcgt tatgccttca aggttcccga 7081 atctgctcgt gaacggtgct gccggcattg cggtaggtat ggcaacaaac attcctccgc 7141 accagctggg agaaatcatt gacggtgtac ttgctgttag tgagaatccg gacattacaa 7201 ttccagagct tatggaagtc attccagggc ctgatttccc gaccgcgggt caaatcttgg 7261 gacgcagcgg tatccggaaa gcatacgaat caggccgagg ctctatcacg atccgggcaa 7321 aagctgagat cgaacaaaca tcttcgggta aagaaagaat tatcgttaca gagttacctt 7381 accaagtaaa taaggcgaaa ttaattgaga aaattgctga tctcgtaagg gacaaaaaga 7441 tagagggtat cacagatctg cgtgatgagt cagatcgtac aggtatgaga attgtcattg 7501 aaatcagacg cgatgccaat gcgaatgtta tcttaaacaa tctgtacaaa caaactgctc 7561 tacaaacatc ttttggcatc aacctgcttg cgcttgttga tggccagccg aaagttttaa 7621 ctcttaagca atgcctggag cattaccttg accatcaaaa agttgtcatt agacgccgta 7681 ctgcttatga attgcgtaaa gcagaagcga gagctcatat cttggaagga ttgagagttg 7741 cactggatca tctcgatgca gttatctccc ttatccgtaa ttctcaaacg gctgaaattg 7801 cgagaacagg tttaattgaa caattctcac tgacagagaa gcaagcacaa gcgatccttg 7861 acatgaggct ccagcgttta acgggactgg aacgtgaaaa gatcgaagaa gaataccagt 7921 ctcttgttaa attaattgca gagctaaaag acatcttggc aaatgaatat aaagtgcttg 7981 agatcattcg tgaagaactc acggaaatca aagagcgttt taacgatgaa agacgtactg 8041 agatcgtcac ttctggactg gagacaattg aagatgaaga tctcatcgag agagaaaata 8101 tcgtagttac tctgacgcac aacggatacg tcaaacgtct tcctgcatca acttaccgca 8161 gtcaaaaacg gggcggaaaa ggtgtacaag gtatgggaac aaacgaagat gatttcgttg 8221 aacatttgat ctctacgtca actcatgaca cgattctctt cttctcgaac aaggggaaag 8281 tgtatcgtgc aaaagggtat gaaatccctg aatacggcag aacggcaaaa ggaatcccga 8341 ttattaacct gctggaggta gaaaagggtg agtggatcaa cgcgattatt ccagtcacgg 8401 aattcaatgc ggagctttac ctcttcttca ctacaaagca tggggtttca aaacgaacat 8461 cgctatctca attcgctaat atccgcaaca atggtctaat tgctctgagt cttcgtgaag 8521 atgatgaact gatgggtgta cgtctgactg acggcacaaa acaaatcatc attggaacga 8581 aaaacggttt actgattcgt ttccctgaaa cagatgtccg agagatggga agaactgcgg 8641 cgggcgtaaa aggcatcacc ctgacggatg acgacgttgt tgtcggcatg gagattttag 8701 aggaagaatc acacgtcctt atcgtaactg aaaaagggta cggaaaacga actcctgctg 8761 aagagtacag aacccaaagc cggggcggaa aaggactcaa aacagcgaaa atcaccgaga 8821 acaacggcca actagtagca gtgaaagcta ctaaaggtga agaggatcta atgattatta 8881 cagctagcgg cgtactcatc agaatggaca tcaatgatat ctccatcacc ggacgtgtca 8941 ctcaaggtgt gcgtctcatc agaatggcag aagaagagca tgttgctaca gtagctttag 9001 ttgagaaaaa cgaagaagat gagaatgaag aagaacaaga agaagtgtga aaaaaagcgc 9061 agctgaaata gctgcgcttt tttgtgtcat aaccctttac agtcataaaa attatggtat 9121 aatcatttct gttgtctttt taaagacaca agcatgacca ttatgactag taaaaacttt 9181 ttcaaaaaag tattgaccta gttaactaaa aatgttacta ttaagtagtc gctttgagag 9241 aagcacacaa agttctttga aaactaaaca agacaaaacg tacctgttaa ttcattttta 9301 taaatcgcac agcgatgtgc gtagtcagtc aaactagggc ctgcacgacg caggtcacac 9361 aggtgtcgcc gcaggatgcg gtgaacttaa cctgtgatcc atttatcgga gagtttgatc 9421 ctggctcagg acgaacgctg gcggcgtgcc taatacatgc aagtcgagcg gacagatggg 9481 agcttgctcc ctgatgttag cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa 9541 gactgggata actccgggaa accggggcta ataccggatg gttgtttgaa ccgcatggtt 9601 caaacataaa aggtggcttc ggctaccact tacagatgga cccgcggcgc attagctagt 9661 tggtgaggta acggctcacc aaggcgacga tgcgtagccg acctgagagg gtgatcggcc 9721 acactgggac tgagacacgg cccagactcc tacgggaggc agcagtaggg aatcttccgc 9781 aatggacgaa agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa 9841 gctctgttgt tagggaagaa caagtgccgt tcgaataggg cggtaccttg acggtaccta 9901 accagaaagc cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagcgt 9961 tgtccggaat tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc 10021 ccccggctca accggggagg gtcattggaa actggggaac ttgagtgcag aagaggagag 10081 tggaattcca cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg 10141 cgactctctg gtctgtaact gacgctgagg agcgaaagcg tggggagcga acaggattag 10201 ataccctggt agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct 10261 tagtgctgca gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac 10321 tcaaaggaat tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac 10381 gcgaagaacc ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt 10441 cgggggcaga gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt 10501 taagtcccgc aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta 10561 aggtgactgc cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct 10621 tatgacctgg gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg 10681 ttaagccaat cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg 10741 aagctggaat cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt 10801 gtacacaccg cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt 10861 ttaggagcca gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc 10921 gtatcggaag gtgcggctgg atcacctcct ttctaaggat attttacgga atataagacc 10981 ttgggtctta taaacagaac gttccctgtc ttgtttagtt ttgaaggaac tttgttcctt 11041 gaataagtta agatgggcct gtagctcagc tggttagagc gcacgcctga taagcgtgag 11101 gtcggtggtt cgagtccact caggcccacc atcttatata acggggcctt agctcagctg 11161 ggagagcgcc tgctttgcac gcaggaggtc agcggttcga tcccgctagg ctccaccaac 11221 gtgttctttg aaaactagat aacagtagac atcacattca attagtaaca caagatatca 11281 catagtgatt ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta 11341 ggagccgatg aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg 11401 atccggagat ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga 11461 attcatagga tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag 11521 agaaagcaaa tgcgattccc tgagtagcgg cgagcgaaac gggatcagcc caaaccaaga 11581 ggcttgcctc ttggggttgt aggacactct gtacggagtt acaaaggaac gaggtagatg 11641 aagaggtctg gaaaggcccg ccataggagg taacagccct gtagtcaaaa cttcgttctc 11701 tcctgagtgg atcctgagta cggcggaaca cgtgaaattc cgtcggaatc cgggaggacc 11761 atctcccaag gctaaatact ccctagtgac cgatagtgaa ccagtaccgt gagggaaagg 11821 tgaaaagcac cccggaaggg gagtgaaaga gatcctgaaa ccgtgtgcct acaagtagtc 11881 agagcccgtt aacgggtgat ggcgtgcctt ttgtagaatg aaccggcgag ttacgatctc 11941 gtgcaaggtt aagcagaaga tgcggagccg cagcgaaagc gagtctgaat agggcgcatg 12001 agtacgtggt cgtagacccg aaaccaggtg atctacccat gtccagggtg aagttcaggt 12061 aacactgaat ggaggcccga acccacgcac gttgaaaagt gcggggatga ggtgtgggta 12121 ggggtgaaat gccaatcgaa cctggagata gctggttctc tccgaaatag ctttagggct 12181 agcctcaagg taagagtctt ggaggtagag cactgattgg actaggggcc cctaccgggt 12241 taccgaattc agtcaaactc cgaatgccaa tgacttatcc ttgggagtca gactgcgagt 12301 gataagatcc gtagtcgaaa gggaaacagc ccagaccgcc agctaaggtc ccaaagtata 12361 cgttaagtgg aaaaggatgt ggagttgctt agacaaccag gatgttggct tagaagcagc 12421 caccatttaa agagtgcgta atagctcact ggtcgagtga ctctgcgccg aaaatgtacc 12481 ggggctaaac gtatcaccga agctgcggac tgttcttcga acagtggtag gagagcgttc 12541 taagggctgt gaagccagac cggaaggact ggtggagcgc ttagaagtga gaatgccggt 12601 atgagtagcg aaagaggggt gagaatcccc tccaccgaat gcctaaggtt tcctgaggaa 12661 ggctcgtccg ctcagggtta gtcgggacct aagccgaggc cgaaaggcgt aggcgatgga 12721 caacaggttg atattcctgt accacctcct caccatttga gcaatggggg gacgcaggag 12781 gatagggtaa gcgcggtatt ggatatccgc gtccaagcag ttaggctggg aaataggcaa 12841 atccgtttcc cataaggctg agctgtgatg gcgagcgaaa tatagtagcg aagttcctga 12901 ttccacactg ccaagaaaag cctctagcga ggtgagaggt gcccgtaccg caaaccgaca 12961 caggtaggcg aggagagaat cctaaggtga tcgagagaac tctcgttaag gaactcggca 13021 aaatgacccc gtaacttcgg gagaaggggt gctctgttag ggtgcaagcc cgagagagcc 13081 gcagtgaata ggcccaggcg actgtttagc aaaaacacag gtctctgcga agccgtaagg 13141 cgaagtatag gggctgacgc ctgcccggtg ctggaaggtt aagaggagcg cttagcgtaa 13201 gcgaaggtgc gaattgaagc cccagtaaac ggcggccgta actataacgg tcctaaggta 13261 gcgaaattcc ttgtcgggta agttccgacc cgcacgaaag gcgcaacgat ctgggcactg 13321 tctcaacgag agactcggtg aaattatagt acctgtgaag atgcaggtta cccgcgacag 13381 gacggaaaga ccccgtggag ctttactgca gcctgatatt gaatgttggt acagcttgta 13441 caggataggt aggagccttg gaaaccggag cgccagcttc ggtggaggca tcggtgggat 13501 actaccctgg ctgtattgac cttctaaccc gccgccctta tcgggcgggg agacagtgtc 13561 aggtgggcag tttgactggg gcggtcgcct cctaaaaggt aacggaggcg cccaaaggtt 13621 ccctcagaat ggttggaaat cattcgcaga gtgtaaaggc acaagggagc ttgactgcga 13681 gacctacaag tcgagcaggg acgaaagtcg ggcttagtga tccggtggtt ccgcatggaa 13741 gggccatcgc tcaacggata aaagctaccc cggggataac aggcttatct cccccaagag 13801 tccacatcga cggggaggtt tggcacctcg atgtcggctc atcgcatcct ggggctgtag 13861 tcggtcccaa gggttgggct gttcgcccat taaagcggta cgcgagctgg gttcagaacg 13921 tcgtgagaca gttcggtccc tatccgtcgc gggcgcagga aatttgagag gagctgtcct 13981 tagtacgaga ggaccgggat ggacgcaccg ctggtgtacc agttgttctg ccaagggcat 14041 cgctgggtag ctatgtgcgg acgggataag tgctgaaagc atctaagcat gaagcccccc 14101 tcaagatgag atttcccatt ccgcaaggaa gtaagatccc tgaaagatga tcaggttgat 14161 aggtctgagg tggaagtgtg gcgacacatg gagctgacag atactaatcg atcgaggact 14221 taaccatatt tttgaatgat gtcacacctg ttatctagtt ttgagagaac actctcaatt 14281 tgtttggtgg cgatagcgaa gaggtcacac ccgttcccat accgaacacg gaagttaagc 14341 tcttcagcgc cgatggtagt cgggggtttc cccctgtgag agtaggacgc cgccaagcaa 14401 gcttaaaccc agctcaatga gctgggtttt ttgtttgtta aaaatgaaga agaaactgtg 14461 aagcgtattt agggaatttc ttttctgata ctaataaaaa ctgctgaatt aacacgtagt 14521 catcacttat atgctgtgtt aataactcat accaccattc tgtttcatac cttgcaatca 14581 tcccaacgtt gtacaaaatc aaataatgaa ttgtcatttc gggaagcctc agaaattgct 14641 ccctttgaga agggatataa tattggttct tttccatgtc aaacaataag ctggtcgatg 14701 tccatggctc cttgtcttgt ggtgaaattt cgaacagcag cccgtgttca tttttttttg 14761 taaaagacca ttgataatga tgggacatgt attcagcaaa ccttgaatca gacattttgt 14821 aattgattac tacttcctcc ggtacaaaaa tttcgttctt atccttctca acttttgtca 14881 taaatcgttc tttctgctga aagtagaaaa tatcgctaag ttctggaatg gccattaata 14941 attttttcat ggtataccgt tcatctacta tatccgattg tccgaataaa tgtttcataa 15001 aatgtacgca taggccattc cgttgtattt tcacttcatc gtcgctaaaa caataatttt 15061 gtttctttcg ttttcttgtt gttacgccat gtgccagtac tgatgtatgg cttggataat 15121 gaggatcacg tgtaattaag catgctttga taagctgtgc cattccataa aataaaagaa 15181 tcggtttgat ttctaaggga gaatatgcgg cttgtttata aaacgattcg gcatgcttta 15241 agaaataaat aaaccgttca ctgtttttaa aagagttttt tttcgcatcg ttaataccgt 15301 ttaagatata aaccttttct agaaatttct gggttgattc aacggagtaa aatagcgcta 15361 agtctttcca ctcatgatat gtcatgtata tttcttaatc ctttccgtta tctaaatatt 15421 tcaactcttt cccgcttcct tgacatgctc ttggctagtt gataatctac atataatatt 15481 ttgccgaaaa gagggggatt tactaatgtg ggaaagtaaa ttttcaaaag aaggcttaac 15541 gttcgacgat gtgctgcttg taccagcaaa gtctgaggta cttccgcgtg atgtggattt 15601 atctgtagaa cttacaaaaa cgttaaagct aaatattcct gtcatcagcg caggtatgga 15661 cactgtaaca gaatcagcaa tggcaattgc aatggcaaga cagggcggct tgggcatcat 15721 tcacaaaaat atgtccattg aacagcaggc tgaacaagtt gataaagtaa agcgttctga 15781 gcgcggcgtt atcacaaatc ccttcttttt aactcctgat caccaagtat ttgatgcgga 15841 gcatttgatg gggaaataca gaatttccgg tgttccgatt gtaaataacg aagaagacca 15901 gaagcttgtt ggaattatta caaaccgtga ccttcgtttt atttctgact actcaatgaa 15961 aatcagcgac gtcatgacga aagaagagct agttactgca tctgtaggaa ctactctgga 16021 tgaagctgaa aagattttgc agaaacataa aattgaaaag cttcctctcg tagatgacca 16081 gaataaatta aaaggtctta tcacaattaa agacattgaa aaagtcattg agttcccgaa 16141 ctcatctaaa gacattcacg gccgcctgat cgttggcgcg gcagttggtg taactggcga 16201 tacaatgact cgcgtcaaaa agcttgttga agccaatgtt gatgtgattg ttatcgatac 16261 agctcacgga cactctcaag gcgttttaaa cacagtcaca aaaatccgtg aaacgtatcc 16321 cgaattaaac attattgctg gaaacgtggc aacagctgaa gcgacaagag cgcttatcga 16381 agctggagca gacgttgtca aagttggaat agggcctggt tcaatttgta ctacacgtgt 16441 tgtagccggc gtgggtgttc cgcaaattac agcaatttat gattgtgcga ctgaagcaag 16501 aaaacacggc aaaacaatca tcgccgacgg tgggattaaa ttctctggcg atatcactaa 16561 agcattggca gccggcggac atgctgttat gctcggaagc ttgcttgcag gcacatcaga 16621 aagccctggt gaaactgaaa tctaccaagg cagaagattt aaggtatacc gcggcatggg 16681 atcagttgct gcaatggaaa aaggaagtaa agaccgttac ttccaagaag aaaacaaaaa 16741 atttgttcct gaaggaattg aaggacgcac accttacaaa gggccagttg aagaaaccgt 16801 ttatcagcta gtcggaggcc ttcgttctgg tatggggtat tgcgggtcca aagatctgcg 16861 tgcgctaaga gaagaagctc agttcattcg catgactggc gcaggacttc gcgaaagcca 16921 tccgcatgac gtacagatta caaaagaatc acctaactat acaatttcat aataaattgt 16981 tacaaattaa aaacatttga cagggtctct gactctgtct atttttttta tactgattat 17041 gataaaattt atactgttgt gcattgaaaa tgtccttaac ggcttaatta tagatgaaga 17101 aaatgaaata cggaggtcgt acgattgaac atcaagaaat gtaaacagct actgatgtca 17161 ttggttgtgt taactctagc tgtcacgtgt ctggctccaa tgtcaaaagc gaaagcagcc 17221 agcgatccaa ttgatatcaa tgcatctgct gctattatga tcgaagcttc ttcaggtaaa 17281 attctttaca gtaaaaatgc agataagaga ctgccaattg cgagtatgac aaaaatgatg 17341 acagagtatc tgttattgga agcaattgat caaggtaaag tgaaatggga ccaaacctat 17401 acgcctgatg actatgtgta tgaaatttcc caagataaca gcttatcaaa cgttcctctt 17461 cggaaagacg ggaaatacac agtaaaagaa ttatatcaag ctacagcaat ttattctgca 17521 aatgctgctg ctattgcgat tgcagaaatc gttgccggtt ctgaaactaa gtttgttgaa 17581 aaaatgaatg caaaagcaaa agaactaggc ttaacagatt acaaatttgt taacgcaaca 17641 ggtcttgaaa acaaagatct tcacgggcat cagcctgagg ggacaagcgt aaatgaagaa 17701 agtgaagttt ctgcaaagga tatggcggtt cttgcggatc acttgattac tgactaccct 17761 gagatactgg agacttccag tatcgccaaa acgaaattca gagaaggcac cgatgatgaa 17821 atggacatgc cgaactggaa ttttatgctg aaggggcttg tcagcgagta taaaaaagcg 17881 actgtagacg gactgaaaac aggttctact gactctgcgg gttcatgctt tacaggaaca 17941 gctgaacgca acggtatgcg tgtcatcact gttgttttaa acgcaaaggg caaccttcat 18001 acaggccgtt tcgatgaaac gaaaaaaatg tttgattatg ctttcgacaa tttctccatg 18061 aaagaaattt atgctgaagg cgatcaagta aaaggccata aaacaatttc agttgataag 18121 ggtaaagaga aagaagtagg cattgtgaca aacaaggcgt tctctcttcc tgtcaaaaat 18181 ggtgaagaaa agaattacaa agcgaaggtc acactgaata aagacaactt aactgctcct 18241 gtgaaaaaag gaaccaaggt tgggaagctg actgcggaat acacaggtga tgaaaaggat 18301 tacggattcc ttaacagcga tctggctggc gtagaccttg ttacaaaaga aaatgtagaa 18361 aaagcaaact ggtttgtttt gacaatgcgc agtatcggcg gattttttgc cggaatttgg 18421 ggaagcattg ttgatacggt aaccggctgg ttttaatcaa ttgaaagagc tctgatggat 18481 gttagggctc tttcgcgtaa tatactgaaa aaacccaatt tttaataaaa aatgattttc 18541 aaagcgctaa aaaccgaata aaatagtata tatgcatatg aattattgga tttctaggat 18601 acaataagga ttagaaatca tataactata ccttgattag ggggaccaag aaatggctca 18661 aacaggtact gaacgtgtaa aacgcggaat ggcagaaatg caaaaaggcg gcgtcatcat 18721 ggacgtcatc aatgcggaac aagcgaaaat cgctgaagaa gctggagctg tcgctgtaat 18781 ggcgctagaa cgtgtgccag cagatattcg cgcggctgga ggagttgccc gtatggctga 18841 ccctacaatc gtggaagaag taatgaatgc agtatctatc ccggtaatgg caaaagcgcg 18901 tatcggacat attgttgaag cgcgtgtgct tgaagctatg ggtgttgact atattgatga 18961 aagtgaagtt ctgacgccgg ctgacgaaga atttcattta aataaaaatg aatacacagt 19021 tccttttgtc tgtggctgcc gtgatcttgg tgaagcaaca cgccgtattg cggaaggtgc 19081 ttctatgctt cgcacaaaag gtgagcctgg aacaggtaat attgttgagg ctgttcgcca 19141 tatgcgtaaa gttaacgctc aagtgcgcaa agtagttgcg atgagtgagg atgagctaat 19201 gacagaagcg aaaaacctag gtgctcctta cgagcttctt cttcaaatta aaaaagacgg 19261 caagcttcct gtcgttaact ttgccgctgg cggcgtagca actccagctg atgctgctct 19321 catgatgcag cttggtgctg acggagtatt tgttggttct ggtattttta aatcagacaa 19381 ccctgctaaa tttgcgaaag caattgtgga agcaacaact cactttactg attacaaatt 19441 aatcgctgag ttgtcaaaag agcttggtac tgcaatgaaa gggattgaaa tctcaaactt 19501 acttccagaa cagcgtatgc aagaacgcgg ctggtaagaa cataggagcg ctgctgacat 19561 gttaacaata ggtgtactag gacttcaagg agcagttaga gagcacatcc atgcgattga 19621 agcatgcggc gcggctggtc ttgtcgtaaa acgtccggag cagctgaacg aagttgacgg 19681 gttgattttg ccgggcggtg agagcacgac gatgcgccgt ttgatcgata cgtatcaatt 19741 catggagccg cttcgtgaat tcgctgctca gggcaaaccg atgtttggaa catgtgccgg 19801 attaattata ttagcaaaag aaattgccgg ttcagataat cctcatttag gtcttctgaa 19861 tgtggttgta gaacgtaatt catttggccg gcaggttgac agctttgaag ctgatttaac 19921 aattaaaggc ttggacgagc cttttactgg ggtattcatc cgtgctccgc atattttaga 19981 agctggtgaa aatgttgaag ttctatcgga gcataatggt cgtattgtag ccgcgaaaca 20041 ggggcaattc cttggctgct cattccatcc ggagctgaca gaagatcacc gagtgacgca 20101 gctgtttgtt gaaatggttg aggaatataa gcaaaaggca cttgtataaa acagttgaaa 20161 gctgtggaaa cttatagtac attataagca caaataaaga tcgaaaagcg ttgataggaa 20221 ctagtaggga gcctctcttt ctaagagagc cgatggttgg tgcgaatcgg tgaaagatgc 20281 tgtctgaatc catccttgag cgaaatgctg aagcgagtag gcatttacgg gataaccgtt 20341 atgtttgaaa gtggaaaacg agtctttgat ttgttttcaa tcagggtggc aacgcgagag 20401 ctctcgtccc tttatgggga tgagggctct ttttattttc gataaatcaa taaaaaaagg 20461 agtgtttcgc atgcttgata cgaaaatgct gagagcaaat tttcaagaaa ttaaagcaaa 20521 gcttgtacac aaaggcgaag acttaactga ttttgataag tttgaggcgc tggatgatag 20581 acgaagagag cttatcggca aggttgaaga gttaaaagga aaacgaaatg aagtttctca 20641 gcaggttgct gtgctgaagc gtgagaaaaa agacgcggat cacattatta aagaaatgcg 20701 tgaagtcggc gaggaaatta aaaagctcga tgaagaatta cggacagtgg aagctgagct 20761 tgatacaatc ctgctctcaa tcccgaatat tccgcatgag tctgtacctg tcggtgaaac 20821 agaagacgac aacgtagaag tgcgtaaatg gggtgaaaag ccttcatttg cttatgagcc 20881 gaagccgcac tgggatattg cggatgagct gggtattctg gattttgaac gtgctgccaa 20941 agtaacagga agccgtttcg tgttctataa aggcttaggt gctcgtctgg agcgtgcgct 21001 ttataacttt atgcttgatc tgcatgtgga tgagtataac tacactgaag tgatcccgcc 21061 atatatggta aaccgcgcaa gcatgacggg aacggggcag cttcctaaat ttgaagagga 21121 tgcatttaaa atcagagaag aagattattt cttaattcca acggcggaag tgccgattac 21181 aaacatgcat cgcgatgaaa tcctttcagg tgacagcctg ccgatcaact atgcggcatt 21241 cagtgcttgc ttccgttctg aagctggttc agcaggacgt gacacacgcg gattaattcg 21301 tcagcaccaa tttaataaag ttgagcttgt aaagtttgtg aagcctgaag attcttatga 21361 agaattagag aaacttacaa accaagcaga acgggttctt cagctgcttg agcttccata 21421 ccgtgtcatg agcatgtgta cgggtgactt aggctttacg gctgcgaaaa aatacgatat 21481 cgaagtttgg attccaagcc aagacacata tcgagaaatc tcttcttgca gcaacttcga 21541 agcgttccag gcgagacgtg cgaatattcg tttcagacgt gaagcgaaag gcaagcctga 21601 gcatgtacac acactgaacg gctcaggact ggcggttgga agaacagttg ctgctatctt 21661 agaaaattat cagcaggaag acggaagcgt tgtgattccg aaagtgcttc gtccttatat 21721 ggggaataga gaagtaatga aaccgtaaat tatggaaagg cgtgcctgac aaggtgcgcc 21781 tttttgctta tgtaaacacg gcattttcat aaaaacaaaa aaagttttta aaaatgcttg 21841 accacacgag aacatacgtg atatagttag tcttgtcgat acggaggaat acccaagtcc 21901 ggctgaaggg atcggtcttg aaaaccgaca ggggtgtcaa agcccgcggg ggttcgaatc 21961 cctcttcctc cgccatattg attttaattc taatgaaaca caagcatata ttggagattg 22021 ttttgtccgt tgcattcggt gcggcggatt ttttatttta aagaaaaagt gaatctcgac 22081 tgagattcac tttttttgat tatcatgaat aactgaagca atttgatcta caatattttc 22141 aatcgagttt tcgtcgttca gaagatcata atcttcaatg cgaagtttta aaacagggca 22201 ggcattaaaa ccgcttatcc agttctcgta gcgtgtatgc atttcttccc aataagaccg 22261 gcttgtctga agctccatct cacggccgcg ttgttcaatc cggtttaaaa tgttctccag 22321 atctccttct aaatagatca acacatctgg atgtgggaaa tacggtgtca ttaccattgc 22381 ttcgaaaagg cttgtgtaag tcttataatc aacctttgac attgtccctt tatcagcatg 22441 catttttgcg aaaattcctg tatcttcata aatcgaacga tcctgtacaa aacctccgcc 22501 ggcttcaaaa attgttttct gttctttgaa gcgttcagct aagaagtaaa tttgaaggtg 22561 aaagctccaa cgttcaaaat catgatagaa cttttccaaa tatggattat gatcgacttc 22621 ctccaacgat gttttaaatc caagccgttt agctaaagtt tttgttaaag tcgattttcc 22681 gacacctact gttcctgcta ctgtaataat tgaattctta gggatatgat gttccttcat 22741 acgataagct cctttacatg ggcggcaatg cgttcaaagt cgctcttatt caaaacgaaa 22801 tcctttgaat caccatctac ggttaacact gtaagttcag ggtctgcttc ctgcagctgc 22861 ttgatggcga cttcataatc tgaaatcagc tgctccaaat agctagtttc aatttttttc 22921 tcaaaggggc gcccgcgttt ttcaatgcgg tgtagcaatg taggcagact ggcctttatg 22981 taaatgatga aattcggctt tggcagatca tccgttagca ggtgatatat ctttttgtat 23041 ttttccagct gatgtggaga caaggttcgt tccgcaaaaa tcacattttt ataaatatga 23101 taatcagcta ttacaggctg tccctttttt aaaaagtgat cactggtgtc ttcaagctgt 23161 ttgtatctgt gacaaagaaa aaacatctcg agctggaagc tccattcctt tatattgtca 23221 taaaacttat caaggtacgg gttatcctct acaatctcat tgatcatagg gaatccgaat 23281 ttttgtgaga gcatcgttgc gagagttgtt tttcctgccc cgataggacc ttctattgca 23341 ataaaagggg ctgtattcat cggaatcctc cttatatctg aaaaacgtgc gtcagttacc 23401 gaccttcata ttgtatcaca acccttgggt gcccccatga aaaaaagacg tttccaaatt 23461 atcgaaacgt ctttttgaca acattaaatt gatcagacag cagcagccag ttttgtggaa 23521 aggaaagacc cagcttccaa tagctgatgc ctcttaaatt cagctcttta atcagattga 23581 attttgcttg aatcgagcgg gcatcctcga accatacctc gtgccttctg ttttctgcat 23641 cagtatagcg gaagaaagga gcttgagcgg tttggtcata ctgaatggaa gcattgttct 23701 gatcagctat gacaatggct tgctgagggc ttactgctct tgctggagtt ccccctgctg 23761 tatatggcag cgtccagtca tatccatata aattctggcc catgacaatt ttgttcgcag 23821 gcatttcagt caaagcatat tctatgacat cacggacagg tccaattgga gaaaccgctt 23881 gaggcggtcc gccgctatag ccccattcat atgtcatgag aacaacaaag tcgacaattt 23941 cgccatgtgc cctgtaatca tgagcttcat accacctgcc ctgctgtgtt gcacttgttt 24001 taggagcaag agccgtagaa atttctaagc cctctcgatg gaaaagatcc cttgcttcgc 24061 ggaggaattg attataggcc tctctatcct ggggccgcaa atattcaaag tcgaaatgaa 24121 tgtcacggaa gccatatctt ctggcattct cgactatttc atttagaagc cgtcttttta 24181 cagtttcgtc gttcaaaagg atccggccaa gttcatcgct gaatgcctgg ttttctaggt 24241 tcgttataat catcatcaat gttgtatttt gactttctgt aatgctcctt aaattcgtta 24301 aaggcggtgc gactaaggtt ccgttccgct gtgcctggaa gctgaatgcg ccaaggtaag 24361 ttaagtaggg cgacgcttct ctggccgcct gctggagatt ttcgctgact tgatttcctc 24421 ggggctccaa ataagcattt gattcgatgt ctcgtttagg agctggaggg atgtataaac 24481 ggaaaccaat ctgaagcacg gtatttaact ggatgcggtt aacccttgcg agctcggctg 24541 ctgttgtatt gaactgccgg gcgatggatg tcagggtatc acctcgcttc acatcataga 24601 actggccagc tattggaatg acaatggttt gtccgacaac aaggctgtcg ggattcggta 24661 tttcattcgt ttcagtgatg tcatttgtgg ttgttctgta ttgtgaagcg atagcagaaa 24721 gagtgtcgcc ttgttttacc acataaattt gaatgaaaaa cgcctccttt catatcgcta 24781 tcaatgtatg aaagaaaagc gctgatcatg tttatttttc tataatttgt tcttccgtcg 24841 taatttctgc gaaaagaaca ttctccatca tggttaaggc gaattcgtta tcttcgtcac 24901 tgtttgacgc gatacagtcc ttaggaatcg tgatgctgta ttccctcata taagcgtcat 24961 tagcggtaaa cagcacgcat atattgccgg ctatacctgt tatgataata tgtctcacct 25021 gcaactcagt aagaagggtg tgaagtgctg tttcgtagaa agcggaatgt ttcggtttga 25081 ttaaaaaata atcagcatct accggagcta tctttgtgat gatatccttg cttctttcat 25141 ttgtgcattc ttgctgtatg tttttaatgt cagcttgcca aagtccataa tgatcattga 25201 tgtaaataat cggccattca ttttgtctcg cgtgctcctt taatgataaa atatgaggaa 25261 cgattttttc tgttttttta gcgagggttt cccccatatc gaattcaaaa ttattgatca 25321 tgtctacaat gagaagggct ttatctgctt tggacaatcg acagtctcct ttccgtttca 25381 gttatagtta atatgtagcc tttttaggca atgaaaaaac tttgaaaaga gagcttatcc 25441 ttatgacaca agatgaactt tatatgaaag aagcaattaa agaagcgaaa aaggctgaag 25501 agaaaggtga agtgccaata ggtgcggtgc ttgtcattaa tggtgaaatt atagcgcgtg 25561 cgcataattt aagagagact gaacagcgat ctattgccca tgcagaaatg cttgtaattg 25621 atgaagcgtg taaggcactc ggaacatggc ggctggaagg tgcgactctt tatgtgacgc 25681 ttgagccttg tccaatgtgt gctggtgcag tcgtactttc tcgagtggaa aaagtggttt 25741 ttggcgcatt tgatccgaaa ggcggctgtt caggcacgct aatgaacctt cttcaggagg 25801 aacgctttaa tcatcaggct gaagtggtga gcggtgtgct tgaggaagaa tgcggcggaa 25861 tgctcagtgc gtttttcaga gaactaagaa aaaagaagaa agccgccagg aaaaacttgt 25921 ctgaatagta cggttgcaat ttttagggga aacagatata cttaagtgtg catcgtaata 25981 gatgcaacat aaaatttgat atttattttg ccgtgctaag cggggaggta gcggtgccct 26041 gtacctgcaa tccgctctag cagggccgaa tcccttctcg aggttcgttt actttaaggc 26101 ctgccttaag taagtggtgt tgacgtttgg gtcctgcgca atgggaattc atgaaccatg 26161 tcaggtccgg aaggaagcag cattaagtga aacctctcat gtgccgcagg gttgcctggg 26221 ccgagctaac tgcttaagta acgcttaggg tagcgaatcg acagaaggtg cacggtaaat 26281 caatcatcaa attttcagac tcacctaata ttaggtgagt tttttgttat gtaaaaagag 26341 cttttggaat cgaaacaagg ttcatgtata atgggaatga tgaataacgg aggagggcaa 26401 acccgtgagt taccaagctt tatatcgagt attcaggcct cagcgctttg aagatgtggt 26461 cggacaagaa cacattacaa aaacgctgca aaatgccctt ttgcaaaaaa agttttctca 26521 cgcctatctg ttttccgggc ctagaggaac cggaaaaacc agtgcagcca aaatatttgc 26581 taaggctgtc aactgtgaac atgctcctgt tgatgagcca tgcaacgaat gtgcggcctg 26641 taaagggata acaaacgggt caatatccga tgtcatagaa attgacgccg cttctaataa 26701 cggtgttgat gagattcgtg acattcgcga taaagtgaag tttgccccat cggccgtcac 26761 atataaggta tatatcatag atgaggtgca tatgctttct atcggcgctt ttaatgcatt 26821 actaaaaaca ttagaagagc cgcctgagca ttgtattttc atattagcaa caactgaacc 26881 gcacaaaatt cctttaacca ttatctctag atgtcagcgt tttgacttta aacgaattac 26941 ctcccaagcg attgtaggcc gcatgaataa aattgttgat gctgaacagc tgcaagtgga 27001 ggaaggatcg ctggaaatca tcgcgagtgc tgcagacgga gggatgaggg atgccctgag 27061 ccttcttgat caggccatat cattcagcgg cgatatcctg aaagtcgaag atgcgctttt 27121 aattacgggt gctgtttctc aattatatat cgggaagctt gcaaaatccc tgcatgataa 27181 aaacgtttct gacgcactgg aaacattaaa tgaattgctt cagcaaggaa aagatccagc 27241 taagctgata gaagatatga ttttctattt cagggacatg ctgctgtaca aaacagcccc 27301 tggcttagag ggagtgcttg agaaagtaaa agtcgatgaa acgttccggg aactaagtga 27361 acaaattccg gctcaggccc tatatgaaat gattgatatt ctgaacaaga gccatcagga 27421 aatgaaatgg acaaatcatc cgcgtatctt tttcgaagtg gccgttgtga agatttgcca 27481 aacctcacat caatctgctg ctgatctccc ggaagtggat atgctgatga aaaaaatcca 27541 gcagctcgaa caggaagtag agcggctcaa aacaacgggc ataaaagcag ctgcggaaag 27601 cccgaaaaaa gaagcgccgc gtgtgccaaa gggcgggaaa tccaattaca aagcgccagt 27661 aggcagaatt catgagattt tgaaggaagc cacaagaccg gatcttgatc tgctcagaaa 27721 cagttggggc aagcttcttg ctcatctcaa acagcaaaac aaagtatcac atgccgcttt 27781 gctgaatgac agtgaacctg tggctgccgg atcggcggca tttgttctga aattcaaata 27841 tgaaattcat tgtaaaatgg tcgctgagga taacaacgga gtccggacta atcttgagca 27901 gattttagaa tcgatgctcg gaaaaagaat ggatttgatt ggcgttccag aagcacaatg 27961 gggtaaaata agagaagaat ttttagaaga tcatcagcag gaaaatgaag gatcaaatga 28021 accggctgaa gaagacccgc ttattgccga agcgaaaaag cttgttggag cggatttaat 28081 tgaaataaaa gactaacaaa atgaaagaga gtgaatgcta tgcgtggcgg aatgggtaat 28141 atgcaaaaaa tgatgaaaca aatgcaaaaa atgcaaaagg acatggcgaa ggctcaagaa 28201 gagcttgcag aaaaggttgt tgaaggaact gcaggcggcg gtatggtaac agtaaaagca 28261 aacggccaaa aagaaatcct ggatgttatc atcaaagaag aagtcgttga tcctgaagat 28321 attgatatgc ttcaagattt agtgcttgct gcaacgaatg aagctttgaa aaaagttgac 28381 gaaatcacaa acgaaacaat gggtcaattt acaaagggaa tgaacatgcc aggtttattc 28441 tagggggata aaagaacatg caatatcctg aaccaatatc aaagctgatt gacagcttta 28501 tgaaattgcc agggatcgga ccgaaaacag cggttcgtct ggcttttttt gttctaggta 28561 tgaaagaaga tgtagtatta gattttgcga aagcattagt aaatgcgaaa cgcaacctga 28621 catattgttc agtttgcggg catattacag atcaggaccc ttgctatata tgtgaagata 28681 cgcgcaggga taagtctgtt atctgtgttg tgcaagaccc taaagacgtt atcgctatgg 28741 agaaaatgaa ggaatacaac ggacagtatc acgttcttca cggcgctatt tctccaatgg 28801 acggcatcgg accggaggat attaaaatac cagaattgtt aaaacgatta caggatgatc 28861 aagtgacaga agtgatcctc gcgacaaacc ctaatataga aggggaagca acagcgatgt 28921 atatatcaag gctcctcaag ccgtctggta ttaagctctc ccgtattgcc cacggactgc 28981 ccgtcggcgg tgatttggaa tatgctgatg aggtcactct ttctaaagca cttgaaggaa 29041 gacgtgaatt gtaaggagga aaaagcgatc catgggtttt cttcgcaaga aaacattaag 29101 aagagagttt gatgaaaaac taaccgagca gctttttaag caaaaggaag agtggaacag 29161 gcaaaaaaag ctggttgaaa aaagcttaga accgtctgct gaagtgttat acgaactgaa 29221 agtagctgaa gcgaagtatt ttttttactt aagggaagcg aagcagcgaa atttaaaaat 29281 cagccggtgg aagtaagtgg tctaaactcc tggatcttct cataagcttg tactagaaca 29341 agcgaaggag atgagaagat tcatggagcc tatttttatt attgggatta ttttaggact 29401 ggttattctt ctttttttat caggttcagc agcgaagcct ttaaagtgga ttggcatcac 29461 agctgttaaa tttgtggcag gtgctttgct gctggtttgt gtaaatatgt ttggcggcag 29521 tcttggcatt catgtgccga ttaatctggt tacaacagct atcagcggaa ttttaggaat 29581 acccggaata gctgcgttag tcgtcattaa gcaatttatc atttaattga tattatgtat 29641 tgacttagac aactgaaggt gttattctaa tatacgtcgc tgatgacgaa cagctttttt 29701 gaaaagaaaa tgctaaaaag ttgttgacag tagcggcggt aaatgttatg ataataaagt 29761 cgcttaaacg agcggtaaac aaagttcttt gaaaactaaa caagacaaaa cgtacctgtt 29821 aattcatttt tataaatcgc acagcaatgt gcgtagtcag tcaaactact ttatcggaga 29881 gtttgatcct ggctcaggac gaacgctggc ggcgtgccta atacatgcaa gtcgagcgga 29941 cagatgggag cttgctccct gatgttagcg gcggacgggt gagtaacacg tgggtaacct 30001 gcctgtaaga ctgggataac tccgggaaac cggggctaat accggatggt tgtttgaacc 30061 gcatggttca aacataaaag gtggcttcgg ctaccactta cagatggacc cgcggcgcat 30121 tagctagttg gtgaggtaac ggctcaccaa ggcgacgatg cgtagccgac ctgagagggt 30181 gatcggccac actgggactg agacacggcc cagactccta cgggaggcag cagtagggaa 30241 tcttccgcaa tggacgaaag tctgacggag caacgccgcg tgagtgatga aggttttcgg 30301 atcgtaaagc tctgttgtta gggaagaaca agtaccgttc gaatagggcg gtaccttgac 30361 ggtacctaac cagaaagcca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 30421 gcaagcgttg tccggaatta ttgggcgtaa agggctcgca ggcggtttct taagtctgat 30481 gtgaaagccc ccggctcaac cggggagggt cattggaaac tggggaactt gagtgcagaa 30541 gaggagagtg gaattccacg tgtagcggtg aaatgcgtag agatgtggag gaacaccagt 30601 ggcgaaggcg actctctggt ctgtaactga cgctgaggag cgaaagcgtg gggagcgaac 30661 aggattagat accctggtag tccacgccgt aaacgatgag tgctaagtgt tagggggttt 30721 ccgcccctta gtgctgcagc taacgcatta agcactccgc ctggggagta cggtcgcaag 30781 actgaaactc aaaggaattg acgggggccc gcacaagcgg tggagcatgt ggtttaattc 30841 gaagcaacgc gaagaacctt accaggtctt gacatcctct gacaatccta gagataggac 30901 gtccccttcg ggggcagagt gacaggtggt gcatggttgt cgtcagctcg tgtcgtgaga 30961 tgttgggtta agtcccgcaa cgagcgcaac ccttgatctt agttgccagc attcagttgg 31021 gcactctaag gtgactgccg gtgacaaacc ggaggaaggt ggggatgacg tcaaatcatc 31081 atgcccctta tgacctgggc tacacacgtg ctacaatgga cagaacaaag ggcagcgaaa 31141 ccgcgaggtt aagccaatcc cacaaatctg ttctcagttc ggatcgcagt ctgcaactcg 31201 actgcgtgaa gctggaatcg ctagtaatcg cggatcagca tgccgcggtg aatacgttcc 31261 cgggccttgt acacaccgcc cgtcacacca cgagagtttg taacacccga agtcggtgag 31321 gtaacctttt aggagccagc cgccgaaggt gggacagatg attggggtga agtcgtaaca 31381 aggtagccgt atcggaaggt gcggctggat cacctccttt ctaaggatat tttacggaat 31441 ataagacctt gggtcttata aacagaacgt tccctgtctt gtttagtttt gaaggaactt 31501 tgttccttga ataagttaag atgggcctgt agctcagctg gttagagcgc acgcctgata 31561 agcgtgaggt cggtggttcg agtccactca ggcccaccat cttatataac ggggccttag 31621 ctcagctggg agagcgcctg ctttgcacgc aggaggtcag cggttcgatc ccgctaggct 31681 ccaccaacgt gttctttgaa aactagataa cagtagacat cacattcaat tagtaacaca 31741 agatatcaca tagtgattct ttttaacggt taagttagaa agggcgcacg gtggatgcct 31801 tggcactagg agccgatgaa ggacgggacg aacaccgata tgcttcgggg agctgtaagc 31861 aagctttgat ccggagattt ccgaatgggg aaacccacca ctcgtaatgg agtggtatcc 31921 atatctgaat tcataggata tgagaaggca gacccgggga actgaaacat ctaagtaccc 31981 ggaggaagag aaagcaaatg cgattccctg agtagcggcg agcgaaacgg gattagccca 32041 aaccaagagg cttgcctctt ggggttgtag gacactctgt acggagttac aaaggaacga 32101 ggtagatgaa gaggtctgga aaggcccgcc ataggaggta acagccctgt agtcaaaact 32161 tcgttctctc ctgagtggat cctgagtacg gcggaacacg tgaaattccg tcggaatccg 32221 ggaggaccat ctcccaaggc taaatactcc ctagtgaccg atagtgaacc agtaccgtga 32281 gggaaaggtg aaaagcaccc cggaagggga gtgaaagaga tcctgaaacc gtgtgcctac 32341 aagtagtcag agcccgttaa cgggtgatgg cgtgcctttt gtagaatgaa ccggcgagtt 32401 acgatcccgt gcaaggttaa gcagaagatg cggagccgca gcgaaagcga gtctgaatag 32461 ggcgcatgag tacgtggtcg tagacccgaa accaggtgat ctacccatgt ccagggtgaa 32521 gttcaggtaa cactgaatgg aggcccgaac ccacgcacgt tgaaaagtgc ggggatgagg 32581 tgtgggtagg ggtgaaatgc caatcgaacc tggagatagc tggttctctc cgaaatagct 32641 ttagggctag cctcaaggta agagtcttgg aggtagagca ctgattggac taggggcccc 32701 taccgggtta ccgaattcag tcaaactccg aatgccaatg acttatcctt gggagtcaga 32761 ctgcgagtga taagatccgt agtcgaaagg gaaacagccc agaccgccag ctaaggtccc 32821 aaagtatacg ttaagtggaa aaggatgtgg agttgcttag acaaccagga tgttggctta 32881 gaagcagcca ccatttaaag agtgcgtaat agctcactgg tcgagtgact ctgcgccgaa 32941 aatgtaccgg ggctaaacgt atcaccgaag ctgcggactg ttcttcgaac agtggtagga 33001 gagcgttcta agggctgtga agccagaccg gaaggactgg tggagcgctt agaagtgaga 33061 atgccggtat gagtagcgaa agaggggtga gaatcccctc caccgaatgc ctaaggtttc 33121 ctgaggaagg ctcgtccgct cagggttagt cgggacctaa gccgaggccg aaaggcgtag 33181 gcgatggaca acaggttgat attcctgtac cacctcctca ccatttgagc aatgggggga 33241 cgcaggagga tagggtaagc gcggtattgg atatccgcgt ccaagcagtt aggctgggaa 33301 ataggcaaat ccgtttccca taaggctgag ctgtgatggc gagcgaaata tagtagcgaa 33361 gttcctgatt ccacactgcc aagaaaagcc tctagcgagg tgagaggtgc ccgtaccgca 33421 aaccgacaca ggtaggcgag gagagaatcc taaggtgatc gagagaactc tcgttaagga 33481 actcggcaaa atgaccccgt aacttcggga gaaggggtgc tctgttaggg tgcaagcccg 33541 agagagccgc agtgaatagg cccaggcgac tgtttagcaa aaacacaggt ctctgcgaag 33601 ccgtaaggcg aagtataggg gctgacgcct gcccggtgct ggaaggttaa gaggagcgct 33661 tagcgtaagc gaaggtgcga attgaagccc cagtaaacgg cggccgtaac tataacggtc 33721 ctaaggtagc gaaattcctt gtcgggtaag ttccgacccg cacgaaaggc gcaacgatct 33781 gggcactgtc tcaacgagag actcggtgaa attatagtac ctgtgaagat gcaggttacc 33841 cgcgacagga cggaaagacc ccgtggagct ttactgcagc ctgatattga atgttggtac 33901 agcttgtaca ggataggtag gagccttgga aaccggagcg ccagcttcgg tggaggcatc 33961 ggtgggatac taccctggct gtattgacct tctaacccgc cgcccttatc gggcggggag 34021 acagtgtcag gtgggcagtt tgactggggc ggtcgcctcc taaaaggtaa cggaggcgcc 34081 caaaggttcc ctcagaatgg ttggaaatca ttcgcagagt gtaaaggcac aagggagctt 34141 gactgcgaga cctacaagtc gagcagggac gaaagtcggg cttagtgatc cggtggttcc 34201 gcatggaagg gccatcgctc aacggataaa agctaccccg gggataacag gcttatctcc 34261 cccaagagtc cacatcgacg gggaggtttg gcacctcgat gtcggctcat cgcatcctgg 34321 ggctgtagtc agtcccaagg gttgggctgt tcgcccatta aagcggtacg cgagctgggt 34381 tcagaacgtc gtgagacagt tcggtcccta tccgtcgcgg gcgcaggaaa tttgagagga 34441 gctgtcctta gtacgagagg accgggatgg acgcaccgct ggtgtaccag ttgttctgcc 34501 aagggcatcg ctgggtagct atgtgcggac gggataagtg ctgaaagcat ctaagcatga 34561 agcccccctc aagatgagat ttcccattcc gcaaggaagt aagatccctg aaagatgatc 34621 aggttgatag gtctgaggtg gaagtgtggc gacacatgga gctgacagat actaatcgat 34681 cgaggactta accacatttt gaatgatgtc acacctgtta tctagttttg agagaacacc 34741 tctctaaagg cggaaggtaa ggaaactccg ctaagggctc tcacatcctg tgagaaacgc 34801 ccagtacctt catcctgaag gcatttgttt ggtggcgata gcgaagaggt cacacccgtt 34861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 34921 gtgagagtag gacgccgcca agcaagctta aacccagctt aatgagctgg gttttttgtt 34981 tactcaagat cgagaaaatc aaacaaatac aaacaccgag ggcttatata gcccatatac 35041 tgatttaaag tttcaaaaag gtctaaatag tgtatacaat atccgtttta aggggaggct 35101 aactgtacgg aggtggagaa gatggacgaa acagttaaac ttaatcatac atgtgtgatt 35161 tgtgatcaag agaagaatag aggcattcat ctttatacga aattcatatg cttagattgt 35221 gagagaaaag taatttctac atcaacttct gatcctgact atgcgtttta cgtaaaaaaa 35281 ctaaagagca ttcatacacc gccattatat tcatagacct gaaaaggtct ttttttgtac 35341 tcttaataat aaaaagaaga tgaaacttgt ttaaggattg aacgtagtag ataataatat 35401 taaaactgag tatagacaca ggagtcgatt atctcatgca gagatttttt cactttttgg 35461 tgtggagttt aactagcagt gcgacttttg ttttcattgg aatattgagc ttttttggtt 35521 taaaccagtc gattttttta tctattgttt atgggcttgc ttctggagca gccgtatata 35581 tagctggcat ctggaatgca agacggttat ttcttaaaaa gcatgaattg acaggaagag 35641 agtatgctta cattaagaaa aacttagagg aagcaaggca gaaaatggtc cgtcttagga 35701 aagccttgtt tcaggctaaa agcattcaaa tgtttaagca aaatgcagaa atgctaagga 35761 ttgtgagaag gatttatctc ctcaccaaaa aagagccaaa gcggttttat caggcagaac 35821 gattttttta tcaaactctc gattcggttg ttgaattgac agagaagtat gcttttctat 35881 catctcaccc aaaaaaaagc aaagaactgt cgatgtcgtt aagtgagaca cgcatcactc 35941 ttactgaatt gaccaagcgt ttagaggaag atttaactca agcaatgggt gatgaaattg 36001 acgagttgca gtttgaatta gacgcagcaa aacattcatt aaagaaataa gggaagaggg 36061 taagagcgat gaaccgagac caaagcgacc ttcatataga tgaattattg gcagatcctt 36121 ttggtggtaa catagagata ccaggttcgg aggctgtaaa agcagagaaa gagcaagtac 36181 ggcttgttga tgttcttcct gaggaaaaca aggaaaaagc aattcagctt gctggacaga 36241 ttgatcataa aaatatgcaa agcattgtct tatacggttc acaagctcaa tctaaactgc 36301 tgaacttttc tcatgatatg attaatcatg ttcaaaagaa ggatgtcggg gagattggcg 36361 aaatacttgg agagctgatg aaaaagctgg agcaagtaaa tcctgatgat ctccaatcta 36421 agaaaaaggg ttttttggca cgcatgtttg gaagagtatc aagttctctt caagaggtgc 36481 tgtctaaata ccaaaagacc agtgtgcaga tagacagaat cagcttgaag ctggagcact 36541 ctaaaaatgc tttaatcagt gacaacaagc tgttagagca gttatatgaa aaaaataaag 36601 aatatttcgc agcgctgaat gtttatattg ctgcaggaga actgaagctg gaggaattaa 36661 aaacaaaaac gattcctgaa ctgaagcaac aggctgaatc gagtgatcat aaccaaatgg 36721 ccgttcaaga ggtgaatgat ttaattcaat ttgctgaccg gttagataaa agggtgcatg 36781 atttgctgct gagcaggcaa attacaatcc aaagtgcacc gcaaatcagg ctgattcaaa 36841 atacaaacca agcgttagct gaaaagattc agtcatccat tgtgacagcg attccgttat 36901 ggaaaaatca agttgccatt gcactgacgc ttttaaggca gcgcaatgca gtggatgcac 36961 agcagaaagt atctgataca accaatgagc ttttgctgaa aaatgcggag cttttaaaaa 37021 ccaatacaat tgaaactgca cgggcaaatg aaagaggcct tgttgatata gataccttga 37081 agaaggtgca ggaaagctta ataagcacgc ttgaagaaac actgactata caagaagaag 37141 gacgaatcaa acgccgtcag gcagaagaag agctcatgat gatggaaggc gacctgaagc 37201 aaaagctgat tacaataaag gaaagatgat taccagtaag tctggcttta agttctgtca 37261 gaggcacgat ataataaggt gtaagaagac acattcaaag gattgttttc atgaacacac 37321 ctttatataa agcattaatt caacatgcga gaagaaattc tcattcattt catgttccgg 37381 gacatcacaa tggagatgtc ttttttgatg acgctaagtc aatattcgat ccgcttctca 37441 ccattgatgt aactgaactg gcaggactgg atgatctcca tcatccttct ggggtgatta 37501 aggaagctca ggagcttgcc agtcaattat atggatcggc ggaaagtttt tttctggtaa 37561 atggtacgac tgtcggaaac ttagcgatga ttttatctgt ttgtgaacct ggtgatacaa 37621 ttctggttca aagaaactgt cataaatctg tatttcatgc tgttgatttg tccggtgctg 37681 agccggttta tcttgcacct gacgttgatt cagcgatgca tgtgcctacg catgttccgc 37741 ttggaacaat taaagaggcc ctggaagcat atccagatgc gaaaggcttg gtactgacca 37801 atccgacata ttacggacat agtgctgatt tgactgagat cattactgaa gcccatcatt 37861 acgggattcc tgttttggtc gatgaagcgc atggcgcaca ttttatttta ggtgagcctt 37921 ttccggtctc agctttaaaa atgggggcag atattgttgt tcagtcggcc cacaaaacgt 37981 tgccagccat gacgatgggt tcttatttgc atctcaacag cagctgcagg attaacaggg 38041 atcgggtggc agagtattta aaccgattac aaagcagcag cccgtcttat ccgattatgg 38101 cttcgttaga tattgcccgc gcttatgtac agcatattat agaagaacaa aagctttctg 38161 acattctgca gcggatagaa acacttaaac aaacgtttga ttcacttaca aatgcagaag 38221 ctgttaaccc tgctaatcca ctgatcatca cggatccgct aaagctcaca attcgttcaa 38281 aacgcgggca ttctggctat acgctgcaaa gcattttaga gcgtgccaac atattcactg 38341 agcttgctga tgaaaatcaa gttctgctcg ttctcccatt gggaggaaaa cggagaataa 38401 acgctgaaat cattagaagc atcgatgaag agattgagaa aacgcctccg gatcagacgt 38461 ttgtttctgc agaatggggt gtgcagcctg ttactgtctt gccttatcca aaaaaggtct 38521 tacattcgtt taagaaagaa tatgtgagct ttgaggaagc agctggccgg cttaatgcag 38581 aagatatcat cccttatcct ccgggtatcc cgatgattat ggcgggagaa agaataacaa 38641 aagaaagtgt gcaaaagctc agccgcttga tcagcatgaa aacgcatgtt caagggaata 38701 tgaaaatcaa agagaaacaa ctacttgttt atatagaaga ggagaaatca tgagcggttt 38761 atttattaca ttcgaaggtc ctgaaggtgc agggaaaacg actgttctgc aggagatcaa 38821 aaacatactg acagcagaag gccttcaggt tatggcaact cgagagccag gcggaataga 38881 tattgcagaa caaattagag aggttattct gaatgagaac aatatattaa tggacccaaa 38941 aacagaagct ctcttatatg cggctgcaag acgccagcat ttagttgaaa aagtaaaacc 39001 tgctttagaa caggggttta tcgttctttg cgacagattc atagacagtt ctcttgcgta 39061 tcaaggatat gcaagagggc ttggaattga tgaggttctg tccattaatg aatttgccat 39121 tggagatatg atgccccatg taacggttta tttttcaatt gatccggaag aaggactgaa 39181 gcgtatttac gcaaacggct cacgggagaa aaacaggctc gatttagaaa aactggactt 39241 tcatacaaaa gtacaagaag gttatcaaga gctgatgaag cgatttccgg aaagatttca 39301 ttcagttgat gccgggcaat ccaaagacct cgtcgttcag gatgttctaa aggtgatcga 39361 tgaagcgttg aaaaaaattc aattgtgacc tgtttcccaa tagttgatat aataatgtaa 39421 acgagatcac gttgtttcca atctaaagga ggccttcaca gatgaaattg atagtggcag 39481 ttgtacaaga tcaggacagc aacagacttt tgaaaacctt aacggatcac aacttcagag 39541 tcacaaagct tgcaacgaca ggaggatttc ttaaatcagg caatacaacg tttatgatcg 39601 gtgtcgagga tatacgcgtc aataaagcgt tgagtctcat taaagaaaac gggcagaaac 39661 gtgatcagat gattgcccct gtatctccaa tgggtggaaa tgctgattcc tatgtccctt 39721 atccagtcga agttgaagtt ggcggagcga cagtatttgt ccttccagtc gatgaatttc 39781 atcaatttta aggatctgaa actgtgaaaa ttaataaaga tatacgtaca tttatagata 39841 ataagcagat tccctctgtg aaaacatctg agatcacagc atcgtttaaa acatcaatgg 39901 aaaaccaaag cagcaaaatg aagcttgatc agcttaccag gctgttatct gatatagaag 39961 catttggaaa aaggctaacg aaatctcgga attttaaaga cttagcgaga tttaaaggac 40021 ttgtgaaacg ttttgtcaaa gaagctgtgg acagcggtct ttcacatgaa acatcgaaaa 40081 gctttgacct ttacgggaac agcagaacgc tgggacttgt gaaagaaata gatgacaaat 40141 tgatacagct tacggaagag atgatggatc aggaaaaacc ggcaattgat ttgctggagc 40201 gtattggcga aataaaaggt ttattaatta acctttacac atagagagtg atacaatggc 40261 aatatcctgg aaggaaatga acgagcttca gcccagagtg atgaagcttt tatataatag 40321 tattgagaag gacagactat cacacgctta tttgtttgag gggaaaaaag gaacaggcaa 40381 gcttgatgcc gcgctgcttc ttgcaaaaag cttcttttgt ctggagggtg gcgcggagcc 40441 ttgtgagagc tgccgaaact gtaaacggat agagtcaggg aaccatcctg atctccatct 40501 tgttcagcct gatggcttat caatcaaaaa ggcgcaaatt caagcgctcc aagaagagtt 40561 ttctaagaca ggacttgaat cgcataaaaa gctgtatatt atttcgcacg cagatcaaat 40621 gacagcaaat gcggcgaaca gcctgctgaa atttttagaa gaaccgaaca aagacacaat 40681 ggccgtcctc atcactgagc agccccaaag gttattggat accatcattt caagatgcca 40741 aacccttcct tttcagcctt tgcagccgaa agcaattgaa gacagactga tcgaacagga 40801 cgtctcgcct catatggcaa ggcttctggc caacatgact aataatgtag cagaagcagt 40861 cgaattaagt cgaaatgatg agtttgcaga gtctagagcg aaagtgataa aattgtatga 40921 agtcctacac cagcggaaag gacatgcttt tttctttatt caagatcaat ggatgccctt 40981 tttcaaagaa aaaacccatc aagaaatggg tcttgatatg ctcttattga tatatcgtga 41041 tgtgttgtcc atccaaatag gaaatgaaga taaattgatt tatcaagact tattccaatc 41101 aataaaacag catgcgctac aatcaacaca acaaagcgtt acgaatcaga tacttgctgt 41161 tttagaagca aagaaacggc ttcattccaa tgtgaatgta caaggattaa tggagcactt 41221 ggtgttaatg ttgcaggagg gataagcttg tacaatgtaa ttggtgtccg ctttaagaaa 41281 gcgggtaaaa tatattattt tgatccgaat ggatttcata tagaacatga cagctgcgta 41341 attgtagaaa ctgtcagagg cgttgagtac ggccaggtcg taattgcaaa taaacaggtg 41401 gatgagcatg atgtggtgct tccccttcga aaagtgatac gtgtggcaga cgatcgcgat 41461 cttctcattg tagaagaaaa taaacaggaa gcactatcag catttgatat ctgccaaaag 41521 aaagtgattg agcatggctt ggatatgaag ctggtcgatg ttgaattcac gtttgatcgc 41581 aataaagtca ttttttactt cactgctgac ggccgagtcg actttagaga gcttgtaaag 41641 gatttggctt ctatctttaa gacaagaatt gagctgcgcc aaatcggagt gagggatgag 41701 gcaaaaatgc tcggaggaat cggtccttgc ggaagaatgc tttgctgttc aacgtttctt 41761 ggagattttg aacccgtttc cattaaaatg gccaaggatc agaacttgtc tttaaatcct 41821 acgaagattt cgggtctttg cggacgattg atgtgctgtc taaaatatga gaacgatgag 41881 tatgagacgg caaaagaaca gcttccggat ataggagaaa tgattacgac agcaaacggt 41941 cccgcgaagg tcgtcggact aaatattctg gaacgggtgc ttcaggtgga actgataaac 42001 cgtgaaaaag tgatagaata tacttgggaa gagctcttgg aagagggcgt cgtatccgca 42061 caaaccacag attaacgagg tgtggaacct tggataaaaa agagttattt gatacagtca 42121 ttaacttaga agaacaaatt ggctcactgt accggcagct gggggatttg aagcagcata 42181 tcggtgagat gattgaggaa aatcatcatt tacagcttga aaacaagcat ttgcgcaaac 42241 ggctggacga tacgacgcag cagattgaaa agttcaaagc tgataaaaaa gaatcaaaaa 42301 cacagaagac agagcaaact gatatagggg aaggatatga taatctggca cgtctgtatc 42361 aagaaggatt tcatatctgc aatgtccact atggaagtgt tcgaaaagag gattgtcttt 42421 tctgtctgtc attcttaaat aaaaaatagg gaaaaggctt ccgcataaga cgggagcctt 42481 tttcaaaggt actgaaagga taagaagatg gtttcattac atgatgatga aagattagat 42541 tatttgctgg cagaggacat gaaaatcata caaagcccaa cagtgtttgc tttttcgttg 42601 gacgctgtgc ttctgtccaa atttgcgtac gttccgattc aaaaagggaa aattgttgat 42661 ttatgcaccg gcaatggtat tgtgccgctg ctgctcagta caagatcaaa agcagacatt 42721 ctgggagtcg aaattcaaga aagactgcat gatatggctg ttcgcagcgt ggagtataat 42781 aagttggacg atcagatcca gatcatacat gatgacctga aaaacatgcc ggagaaactt 42841 ggacataatc gatatgatgt tgtcacctgc aatccgccgt attttaaaac gccgaaacaa 42901 actgaacaaa acatgaacga gcatctccga atcgcaagac atgaaatcca ctgcacgctg 42961 gaggatgtca tttcagtcag cagcaagctg ctcaagcaag ggggaaaagc agctcttgtt 43021 caccggccgg gaaggcttct ggagattttt gaactgatga aggcttatca aatcgagccg 43081 aaacgtgtac aatttgtcta tccgaagcaa gggaaagaag ccaataccat tttggttgaa 43141 ggtatcaaag gcgggcgccc ggatttgaaa attcttcctc ccttattcgt atatgatgaa 43201 caaaatgaat atacaaaaga aatcaggacc attttatatg gagacaaata accatttctt 43261 ctacgtcgtg aaatgtaagg acaatagctg gtatgccggg tataccaacg atctgcataa 43321 acgagtgaaa acgcacaatg atggaaaggg cgcaaagtac acaaaagtaa gacgtccggt 43381 tgaattaatt tttgccgaga gcttttcaac aaagcgggaa gctatgcagg cggaatatta 43441 tttcaaaaaa ctaactcgga agaaaaaaga gctttatata gaagaaaagc ggaacagcaa 43501 ggaggctgta tatgttaagg cgccaaatga gctttaatgg aaagtcggac atggggattc 43561 tttacttggt cccaacccca atcggaaatt tagaggatat gacattccgg gcgatcgaca 43621 cgctgaaatc agtggatgcg attgctgcgg aagatacgag gcaaacgaaa aagctttgtc 43681 atgtatatga aattgaaaca ccgctcgtca gctatcacga acacaataaa gaaagcagtg 43741 ggcacaaaat tattgaatgg ctgaaatcgg gaaaaaacat tgctcttgtc agtgatgccg 43801 gtctgccgac gatttctgat cccggagcgg aaattgtaaa ggattttacg gatataggcg 43861 gttatgttgt tccgttgccg ggagcaaatg ctgcattaac agctcttatt gcttcaggta 43921 ttgtaccgca gccttttttc ttttacggtt ttctcaacag acagaaaaaa gaaaagaaga 43981 aggagcttga agcccttaaa aaacggcagg aaacgatcat tttttatgaa gcgccccaca 44041 gattgaagga aaccttgtca gcgatggcag agatattagg agatcgggaa attgctgtaa 44101 cacgtgaact cactaagaaa tatgaagagt ttatccgagg aaccatatct gaggtcattg 44161 gatgggcaaa cgaggatcag atacgcggcg agttttgtct tgtcgtagaa ggaagtaata 44221 atgaagaggt agatgaggaa gaacaatggt gggaaaccct cactgcgaaa gaacatgtcg 44281 agcattacat ttcgaaaggc gctacgtcta aagaagctat taaaaaagca gcagtcgatc 44341 gcaatgtacc aaagcgtgaa gtgtacgatg cttaccatat taagcaataa aaaaacgttc 44401 ttgtgtcata acaagaacgt tttttgtaca agaaatgatt atttaaggtt ttgaagctgg 44461 ttttggattt cgctgatgat ttgctcagcg ccttctttac taagaaccaa tttaccgcct 44521 gcaagtttaa ggttatcatc agaaacttca ccagttactt ggcaagtcat gtttggttta 44581 tattttttaa ggatgatttt ttcatcatca acatagattt caagagcatc tttttctgcg 44641 attccaagag tacgacgcag ttcgatagga ataactacac gtcctaattc atcaacttta 44701 cgtacaatac cagtagattt cataaacatt ctcctcccaa gagatactta tttgtttaaa 44761 ttatattttt cttcgtcatt attcgacaaa atccttacct tcatagcata acaaggtttc 44821 caataatcgt caatcatttt gtttactatt gattgtaaga attagttctt atagtcagta 44881 atgtcttgga aactaccgaa ataacagcat tttataaata tttaataaag ctattatcct 44941 actaaaaatc cttttaaatc aagactttcg aaccaaagtt ttttatttca tttgattata 45001 tacgacaaaa ttcgacacga acagactttt tttattttca ttaaagattt ttaattttaa 45061 ttattctttt tcagggcgta tgtatatatt cttgatctta aaggctaaga tggtatcata 45121 gataaaggat aaatataaat aatattcata tatgatttgc acttatcgcc gctctcgtcc 45181 tttgggcggg agctttttga cattctgatt aggaggtttc aagatgccgc aagaaaacaa 45241 tacattttac attacaacac cgatttatta tccgagcgga aaattacata tcggccatgc 45301 atatacgaca gtcgcaggag atgcaatggc acgttacaaa agattaaaag ggttcgatgt 45361 tcgctattta acgggaacgg acgagcatgg acaaaagatc cagcaaaaag ctgaacagga 45421 aaacattaca cctcaggagt atgtggatcg cgcagcggca gatattcaaa aactgtggaa 45481 gcagcttgaa atctcaaacg acgactttat ccgcacgaca gaaaaacggc ataaagttgt 45541 cattgaaaaa gtgtttcaaa agcttcttga taacggggac atctatcttg atgagtatga 45601 aggctggtac agcatccctg atgaaacgtt ctacacggaa actcagctcg ttgatattga 45661 gcggaatgaa aagggagagg tcatcggcgg aaaaagccct gacagcggtc acccagttga 45721 attgatcaaa gaggaatctt atttcttccg catggggaaa tacgcggatc gtcttctgaa 45781 atactatgaa gaaaacccga cattcattca gccagaatca cgcaaaaacg aaatgattaa 45841 taactttatc aaacctggac ttgaggattt ggcagtatca cgtaccactt ttgattgggg 45901 cgtgaaggtg ccggaaaatc caaagcatgt tgtatatgtt tggattgacg cactatttaa 45961 ctatttaacg gcactcggtt atgatacaga aaatgatgag ctttatcaaa aatattggcc 46021 tgccgatgtt catttagtcg gtaaggagat tgtacgattc catactattt actggccaat 46081 tatgctgatg gcgctggatc ttccgctgcc aaagcaagta ttcgcgcatg gctggctttt 46141 gatgaaagac ggaaaaatgt cgaaatcaaa aggaaacgtt gtagatccgg ttacattaat 46201 tgaacgctat ggtttagacg aacttcgcta ttacttgctt cgcgaagtgc cgttcggatc 46261 agacggtgtt ttcacgccgg aaggatttgt tgagcgaatc aactatgatt tagcgaatga 46321 tttaggaaat ctattgaatc gtactgttgc gatgattaat aagtattttg acggacaaat 46381 cggttcttac aaaggtgctg ttacggaatt tgaccatacg ctcacttctg ttgctgaaga 46441 aacagtgaaa gcttatgaga aagcaatgga aaatatggag ttctcggtag cactttcgac 46501 tttatggcag ctcatcagcc gcacaaacaa atacattgat gagacagctc catgggtgct 46561 tgcgaaagat ccggcaaaag aagaagaatt gcgatcagtt atgtatcatc tcgctgaatc 46621 attgcgtatt tcagcggtac tgcttcagcc attcttaaca aaaacacctg aaaaaatgtt 46681 cgagcagctg ggcattactg atgaatcttt aaaagcttgg gacagcatta cagctttcgg 46741 ccagctgaaa gatacaaaag tacaaaaagg cgagccattg ttccctcgtt tagaggcaga 46801 agaagaaatt gcttacatca aagggaaaat gcaaggttca gcaccagcga aagaagaaac 46861 aaaagaagaa gagcctcaag aggtcgatcg tttacctgaa attacgattg atcaatttat 46921 ggatgtagag cttcgcgtag ctgaggtcat tgaggcagag ccagtgaaaa aagcagaccg 46981 tttattgaag ctgcagcttg atcttggttt tgaaaagcgc caagtggtat ccggcattgc 47041 gaagcattat acgcctgaag agcttgttgg aaaaaaactc gtttgtgtaa caaatctaaa 47101 accggttaaa ctcagaggag agctttctca aggtatgatc cttgcaggag aagcagacgg 47161 cgttttaaag gtcgtatcta tcgatcagtc gttaccaaaa ggcacaagaa ttaaataatg 47221 ataaacaaaa ggtgtttcac gtgtaacaat tcgtcgaaca ccttttgtgt ttcgacaaga 47281 aaggagtttt tcacttatgt tgtttgacac tcacgcgcat ttaaatgcag aacaatatga 47341 tactgatctt gaagaggtta ttgaacgggc aaaagctgaa aaagttgaac gaattgtcgt 47401 agttggtttt gaccgtccga cgattacccg tgcgatggaa atgattgagg aatatgattt 47461 tatttatgca gccattggct ggcaccctgt tgacgctatt gacatgacag aggaagactt 47521 agcgtggatt aaagagcttt ctgctcatga gaaagtggta gcgatagggg aaatgggact 47581 ggattatcat tgggataaat cacctaaaga tattcaaaaa gaggtgttta gaaatcaaat 47641 cgccttagcg aaagaggtca atttgcctat tatcattcat aaccgtgatg caacggagga 47701 tgtcgtgacc attttgaaag aggaaggcgc agaagctgtg ggcggaatca tgcactgctt 47761 tacaggaagt gcggaagtgg caagagaatg catgaaaatg aatttttatt tatcatttgg 47821 gggaccggtg acatttaaaa atgcgaagaa accgaaggaa gtagtgaagg aaattcccaa 47881 tgaccggctg ctgattgaaa cggactgccc gtttctcaca ccgcaccctt tccgcgggaa 47941 aagaaatgag ccaagctatg tgaaatatgt ggcagaacaa atcgccgaat taaaagaaat 48001 gacctttgaa gagattgctt ccatcacgac tgaaaatgcg aaaagacttt tccgtataaa 48061 ctgacaaaaa acgctagcgg gttttgtaag agcttgtccc ttacagcgtt tttctataaa 48121 agttctacat gctttcttct cctcatagga taggtttgtc gacaagtctt tcttccgttt 48181 ctcagtgtat ttcaggataa tgaagaggac actgagcttt tgggagaaag agaagggagg 48241 gttgacagcc ttttagatac tctatataat ctctccgagg agaaggaggc gtttttcatc 48301 acacaaaaaa tgaaaaagct gttttccgta aagcttagca aaagcaaagt cattctggtt 48361 gctgcttgtt tgcttttggc aggaagcggg actgcgtacg cggctcatga gctgacgaaa 48421 caatcagtct cagtttctat caatggcaaa aagaaacata tacgcacaca tgcaaataca 48481 gtcggtgatc ttttggagac gcttgatata aagacaagag acgaagacaa gatcacacct 48541 gctaaacaga caaagataac agcagacatg gacgttgtgt atgaggctgc aaaacctgtg 48601 aagcttacaa taaacgggga agaaaagacg ttatggtcaa cagcaaaaac ggtcggtgca 48661 ttactggacg aacaagatgt tgatgtgaaa gaacaagatc aaattgatcc cgcaatagat 48721 acagatattt cgaaagacat gaagattaac atagagcccg catttcaggt tactgtgaat 48781 gatgcaggga aacaaaagaa gatctggacg acttcgacta cggtcgctga ctttttaaaa 48841 cagcaaaaga tgaacataaa agacgaagat aaaatcaagc ctgcgttaga tgcaaagctg 48901 acgaaaggaa aggctgatat tacaattact cgtatcgaaa aggtcaccga tgtagttgaa 48961 gagaagattg cgttcgatgt gaaaaagcaa gaagacgctt ctcttgaaaa agggaaagaa 49021 aaggtcgtcc aaaaaggaaa agaaggcaag ctaaaaaaac atttcgaagt cgttaaagaa 49081 aacggtaaag aagtgtccag agagcttgta aaagaagaaa cagctgaaca aagcaaagat 49141 aaagtgattg ctgtcggcac aaagcaaagc agtccaaaat ttgaaacggt cagtgcttca 49201 ggtgattcaa aaacagttgt gtcccgcagc aatgaatcaa caggcaaagt catgactgta 49261 tcatctacgg cttatacggc aagctgcagc ggttgttcag gacatacagc gacaggcgtc 49321 aatttaaaaa ataatccgaa tgccaaagtc atcgctgtgg atccaaatgt cattccgcta 49381 ggctccaaag tccacgtgga aggctatgga tatgccattg ctgcagatac cggttcagcg 49441 attaaaggga acaagataga cgtctttttc ccagagaaat catcggcgta ccgatgggga 49501 aataaaacag tcaaaattaa aatcttaaat tagtatatac ttatgtattc agagggtttt 49561 gcgccctctg tttttttcgt tataatagac aaagtgcatt ttctgcttat tagacgctcg 49621 atataagaaa aagtttcatg aatatacaaa agtttttatt ttgtcttgga ggaaataatg 49681 aaaattaaag agatcattgt ggtcgagggg cgtgacgata cggcccgcat caaattggct 49741 gttgatgcag acacaattga aacaaatggt tcagccatcg atgatcatgt gattgaccaa 49801 atccgtttgg cccagaagac gagaggcgtc attattttaa cggatccgga ctttccggga 49861 gagaagattc gcaaaaccat ctcagaggct gtacccggct gtaagcatgc atttttgcca 49921 aaacatcttg ccaaacctaa aaacaagcgg ggaattggtg tggagcatgc atcggttgaa 49981 agcattaggg catgtttaga aaatgtgcat gaggagatgg aagcgcagcc gagtgacatt 50041 tcagctgagg atttgattca tgccggacta ataggcgggc ctgcggccaa atgccgccgg 50101 gaacgactgg gtgatctgtt gaaaatcggc tatacaaatg gcaaacagct tcaaaaacgg 50161 ctgcaaatgt ttcaaattaa aaaaagtgat tttatgagtg cgctcgatac cgttatgcgg 50221 gaggaacaga atgaataaag atattgcgac accgattaga acgaaagaga tactgaagaa 50281 atacggtttt tcttttaaaa agagcttagg acagaatttc ttaattgata cgaacatttt 50341 aaacagaatt gttgatcacg cggaagtgac ggagaaaaca ggtgtcattg aaatcggccc 50401 gggaatcggg gctttaaccg aacagcttgc caagcgggcg aaaaaggtcg tggcatttga 50461 gattgaccag cgattattgc cgattctgaa ggatacactg tcaccttacg aaaatgtcac 50521 tgtcattcat caggacgtgt taaaggctga tgtcaaatca gtcattgaag aacaatttca 50581 agattgtgat gagatcatgg tagttgccaa ccttccttat tacgtaacaa caccgattat 50641 catgaaactg cttgaagaac atcttccgct gaaagggatt gtggttatgc tgcaaaaaga 50701 agtggctgag cgcatggcgg ctgatccttc atctaaggaa tacggctcgc tttcaatcgc 50761 ggtgcagttt tatacagaag ccaaaacggt gatgatcgtc ccgaaaaccg tatttgttcc 50821 tcagcctaat gtcgattccg cagtcattcg tctgattctc cgagacggcc cggcagtgga 50881 cgtggaaaac gaatcctttt tctttcagct catcaaggca agctttgcac agcgccgtaa 50941 aacgctgctc aataacttag ttaacaatct gcctgaagga aaagcacaaa aatcaacgat 51001 tgaacaagtg ctcgaagaaa caaatattga cggtaagcgc cgaggtgaat ccctgtctat 51061 tgaggaattc gcagcgctgt ctaacggatt gtataaagcc cttttctaaa agggcttttt 51121 gttttgcgca ccacatggac tgccgctaca taggctagag aaggaccttt cattcaatga 51181 taagaaaaaa cttggactca gcgaaaaaag gcgctttctc aaggctcttt ctttcatgat 51241 gaggcttagt ctatgtgtgg agtgaggaac gtgcaatttc aaatagggga tatggtagcc 51301 agaaaatcct atcagatgga tgttttgttt cgaattatag gaatagagca aacaagcaaa 51361 ggaaattcaa ttgccatttt gcatggagat gaagtcaggc tgattgctga ttcggatttt 51421 tctgatctgg tggcagtgaa aaaggatgag cagatgatgc ggaaaaagaa agatgagagc 51481 agaatgaatg agtcgctcga attgctccgc caagattata agctgctcag agaaaagcag 51541 gagtactatg cgacaagcca atatcagcat caggagcatt atttccatat gccgggcaaa 51601 gtgcttcatc tggatggtga cgaagcatat ttgaaaaaat gcctgaatgt ctataaaaaa 51661 attggagtgc cggtctatgg catccattgc catgaaaaga aaatgtctgc ttctattgaa 51721 gtattgctcg acaaatatcg acctgacatc ctggtgatca cagggcatga tgcgtactcg 51781 aagcaaaagg gcggtattga tgatttgaat gcgtacagac attctaagca ctttgttgaa 51841 acagttcaaa cagcccgaaa aaagatccct cacttagatc agcttgttat ttttgcgggg 51901 gcctgccaat cccattttga atcactcatc agagcgggtg cgaattttgc aagttcaccg 51961 tcaagagtca atattcatgc gcttgatccg gtatatatcg tcgcgaagat cagctttacg 52021 ccgtttatgg aacggattaa tgtatgggaa gtgctccgta atacgctgac aagagagaaa 52081 gggcttggag gtattgaaac aagaggagtt ctgagaattg gtatgcctta taagtccaat 52141 taacagttga aaacctgcat aggagagcta tgcgggtttt ttattttaca taatgataca 52201 taatttaccg aaacttgcgg aacataattg aggaatcata gaattttgtc aaaataattt 52261 tattgacaac gtcttattaa cgttgatata atttaaattt tatttgacaa aaatgggctc 52321 gtgttgtaca ataaatgtag tgaggtggat gcaatggcga agacgttgtc cgatattaaa 52381 agatcgcttg atgggaattt aggtaaaagg ctgacgttaa aagcaaacgg tggccgccga 52441 aaaacgattg agcgttcggg cattttagct gagacgtacc cttctgtttt tgtgatacaa 52501 ctagatcaag acgagaactc gtttgaaaga gtttcataca gttatgctga tattttgact 52561 gagactgttg agctgacatt taatgatgac gccgcaagct cagtggcatt ttaacgggca 52621 gtgaaccttt tgtttactgc tttttgtttt gccctttttt ggtttccaat aattttaacg 52681 aaagttccat ctgatttaac aaaagataaa acagtcacat attatcgtga cgtgcacgaa 52741 tggctatcac ttctaaaaaa ggagttgttt cgtttgggca gacgtcgtgg agttatgtca 52801 gatgagttta aatatgagct ggctaaagac cttggttttt atgacacagt aaaaaatgga 52861 ggctggggtg aaattcgggc ccgcgatgcc ggtaacatgg tgaagcgtgc tattgaaatc 52921 gccgaacagc aaatggctca gaatcagaat aaccgataag gatgtgaccc gggggacgtg 52981 ctgttccctg gtttttttat tttggatata aatacataat gggctgaata tggatatgtt 53041 catcctgtac ttcaaatgtg atacaatgtt catacttatg tttagatgga gaagtaggtg 53101 aaagctatgc gtattttaga aaaagcgcca gctaagatca atctgtcact tgacgtcacc 53161 cgaaaacgcc cggatggcta tcatgaagtc gaaatgatca tgacgacaat tgatttagct 53221 gatcgaattg aattgacgga gcttgcagag gatgaagtga gggtttcctc ccacaaccga 53281 tttgtgcctg atgaccaaag aaacttagct tatcaggctg ccaagctgat caaggacaga 53341 tacaacgtga aaaagggagt ttccatcatg attacgaagg taattccggt ggctgccggt 53401 cttgccggcg gaagcagtga tgcggcggcg acactcagag ggctgaacag actgtggaat 53461 ttaaatctgt ccgcggaaac gcttgctgag cttggagcgg aaattggctc tgacgtttca 53521 ttttgtgtct atggcggaac tgcattagca acagggcgcg gcgagaaaat taaacatatc 53581 agcacgcctc cgcactgctg ggtcatttta gcgaagccga caatcggtgt ttcaactgct 53641 gaagtgtaca gagcgctgaa actggatggt atagagcatc ccgatgtaca aggcatgatc 53701 gaggcgatag aagaaaagag ttttcagaag atgtgcagcc ggttaggcaa tgtgcttgaa 53761 tctgttacac tcgatatgca tcctgaagtt gcgatgatca aaaaccagat gaaacgcttt 53821 ggtgcagatg ccgtgttaat gagcgggagc ggcccgacag tgtttggact ggttcagtat 53881 gagtcgaagg tgcagagaat ttataacggg ttaagaggct tctgcgatca agtttatgcg 53941 gtgagaatga tcggcgaaca gaacgctctt gattaaatcc gtatgttaag ttatattgat 54001 cttaaaatat tcggattttg ggggtgagtt catgaagttt cgtcgcagcg gcagattggt 54061 ggacttaaca aattatttgt taacccatcc gcacgagtta ataccgctaa cctttttctc 54121 tgagcggtat gaatctgcaa aatcatcgat cagtgaagat ttaacaatta ttaaacaaac 54181 ctttgaacag caggggattg gtactttgct tactgttccc ggagctgccg gaggcgttaa 54241 atatattccg aaaatgaagc aggctgaagc tgaagagttt gtgcagacac ttggacagtc 54301 gctggcaaat cctgagcgta tccttccggg cggttatgta tatttaacgg atatcttagg 54361 aaagccatct gtactctcca aggtagggaa gctgtttgct tccgtgtttg cagagcgcga 54421 aattgatgtt gtcatgaccg ttgccacgaa aggcatccct cttgcgtacg cagctgcaag 54481 ctatttgaat gtgcctgttg tgatcgttcg taaagacaat aaggtaacag agggctccac 54541 agtcagcatt aattacgttt caggctcctc aaaccgcatt caaacaatgt cacttgcgaa 54601 aagaagcatg aaaacgggtt caaacgtact cattattgat gactttatga aagcaggcgg 54661 caccattaat ggtatgatta acctgttgga tgagtttaac gcaaatgtgg cgggaatcgg 54721 cgtcttagtt gaagccgaag gagtagatga acgtcttgtt gacgaatata tgtcacttct 54781 tactctttca accatcaaca tgaaagagaa gtccattgaa attcagaatg gcaattttct 54841 gcgttttttt aaagacaatc ttttaaagaa tggagagaca gaatcatgac aaaagcagtc 54901 cacacaaaac atgccccagc ggcaatcggg ccttattcac aagggattat cgtcaacaat 54961 atgttttaca gctcaggcca aatccctttg actccttcag gcgaaatggt gaatggcgat 55021 attaaggagc agactcatca agtattcagc aatttaaagg cggttctgga agaagcgggt 55081 gcttcttttg aaacagttgt aaaagcaact gtatttatcg cggatatgga acagtttgcg 55141 gaagtaaacg aagtgtacgg acaatatttt gacactcaca aaccggcgag atcttgtgtt 55201 gaagtcgcga gactcccgaa ggatgcgtta gtcgagatcg aagttattgc actggtgaaa 55261 taataagaaa agtgattctg ggagagccgg gatcactttt ttatttacct tatgcccgaa 55321 atgaaagctt tatgacctaa ttgtgtaact atatcctatt ttttcaaaaa atattttaaa 55381 aacgagcagg atttcagaaa aaatcgtgga attgatacac taatgctttt atatagggaa 55441 aaggtggtga actactgtgg aagttactga cgtaagatta cgccgcgtga ataccgatgg 55501 tcgcatgaga gcgattgcat ccatcacgct ggatcacgaa tttgttgtac atgatattcg 55561 tgtgattgat ggaaacaatg gtcttttcgt tgcgatgccg agtaaacgca cccctgatgg 55621 agagttccgc gatattactc atcctattaa ttcaagcacg cgaggaaaga ttcaagatgc 55681 cgtgttaaat gagtatcatc gtctgggtga cactgaagca ttagaattcg aagaagctgg 55741 agcttcttaa aaaataacca aaaagcaagg actgctgaaa gggctgacat aagccttttg 55801 ccggcggtcc ttttttaatt ctgatttttc aaacttagtt gcactcaata gaaaattctt 55861 gcacttcatg aagtctcctt gaaatcagaa gatatttagg atatattttt ctatggataa 55921 aagggatatt ggaggccaat aaatggataa gcggtttgca gttgttttag cggctggaca 55981 aggaacgaga atgaaatcga agctttataa agtccttcat ccagtttgcg gtaagcctat 56041 ggtagagcac gtcgtggacg aagccttaaa attatcttta tcaaagcttg tcacgattgt 56101 cggacatggt gcggaagaag tgaaaaagca gcttggtgat aaaagcgagt acgcgcttca 56161 agcaaaacag cttggcactg ctcatgctgt aaaacaggca cagccatttc ttgctgacga 56221 aaaaggcgtc acaattgtca tttgcggaga tacgccgctt ttgacagcag agacgatgga 56281 acagatgctg aaagaacata cacaaagaga agcgaaagct acgattttaa ctgcggttgc 56341 agaagatcca actggatacg gccgcattat tcgcagcgaa aacggagcgg ttcaaaaaat 56401 agttgagcat aaggacgcct ctgaagaaga acgtcttgta actgagatca acaccggtac 56461 gtattgtttt gacaatgaag cgctatttcg ggctattgat caggtgtcta atgataatgc 56521 acaaggcgag tattatttgc cggatgtcat agagattctt aaaaatgaag gcgaaactgt 56581 tgccgcttac cagactggta atttccaaga aacgctcgga gttaatgata gagttgctct 56641 ttctcaggca gaacaattta tgaaagagcg cattaataaa cggcatatgc aaaatggcgt 56701 gacgttgatt gacccgatga atacgtatat ttctcctgac gctgttatcg gaagcgatac 56761 tgtgatttac cctggaactg tgattaaagg tgaggtgcaa atcggagaag atacgattat 56821 tggccctcat acggagatta tgaatagtgc cattggcagc cgtacggtta ttaaacaatc 56881 ggtagtcaat cacagtaaag tggggaatga tgtaaacata ggaccttttg ctcacatcag 56941 acctgattct gtcatcggga atgaagtgaa gatcgggaat tttgtagaaa ttaaaaagac 57001 tcaattcgga gaccgaagca aggcatctca tctaagctat gtcggcgatg ctgaggtagg 57061 cactgatgta aacctgggct gcggttcaat tactgtcaat tatgatggaa agaataagta 57121 tttgacaaaa attgaagatg gcgcgtttat cggctgcaat tccaacttgg ttgcccctgt 57181 cacagtcgga gaaggcgctt atgtggcggc aggttcaact gttacggaag atgtacctgg 57241 aaaagcactt gctattgcca gagcgagaca agtaaataaa gacgattatg tgaaaaatat 57301 tcataaaaaa taatcctaaa ttcggaggtt tatccatgtc taatcaatac ggagataaga 57361 atttaaagat tttttctttg aattcgaatc cagagcttgc aaaagaaatc gcagatatag 57421 ttggagttca attagggaaa tgttctgtca caagatttag tgacggggaa gtccaaatta 57481 atatcgaaga aagtattcgc ggatgtgatt gttacatcat ccagtctaca agtgaccccg 57541 ttaacgagca tattatggaa ctgctgatta tggtagatgc gttaaaacgc gcttctgcaa 57601 aaacgattaa cattgttatt ccttattacg gttatgcgcg tcaagacaga aaagcaagat 57661 cccgtgagcc aatcacagct aaacttttcg ctaacctgct tgaaacagcc ggtgcgactc 57721 gtgtgattgc acttgacctg catgcgccgc aaattcaagg attctttgat ataccgattg 57781 accacttaat gggtgttccg attttaggag aatattttga aggcaaaaat cttgaagata 57841 tcgtcattgt ttcaccagac catggcggtg tgacacgtgc ccgcaaactg gctgaccgac 57901 taaaagcgcc aattgcgatt atcgataaac gccgtccgcg tccaaacgtg gcggaagtca 57961 tgaatattgt aggtaacatc gaagggaaga ctgctatcct catcgatgac attattgata 58021 ctgcaggtac gattacactt gctgctaatg cgctcgttga aaacggagcg aaagaagtat 58081 atgcatgctg tacacaccct gtactatcag gccctgcggt tgaacggatt aataattcaa 58141 caattaaaga gcttgttgtg acaaacagca tcaagcttcc tgaagaaaag aaaattgaac 58201 gctttaagca gctttcagtc ggaccgcttc tggccgaagc gattattcgc gttcatgagc 58261 agcaatcagt cagctatctg ttcagctaaa ccatttttcg aggtttaaat ccttatcgtt 58321 atgggtattg tttgtaatag gacaactaaa acgacaagag gatggtgctg aatatggcaa 58381 ctttaacggc aaaagaaaga acggacttta ctcgttcgtc tcttcggaat atccgtactt 58441 caggacatgt tccaggtatc atatatggga aggatacggg taacaaacct gtgtcattag 58501 acagtgtgga gctcatcaaa acgctgaggg acgaaggcaa aaatgcagtc attacgcttg 58561 aggtcagcgg agaaaaacac tcagtcatgg taacagacct gcagacggac ccgctgaaaa 58621 atgaaatcac tcatgctgat tttcaagtag ttaatatgag tgaggacatt gaagtggaag 58681 ttccgattca tctgaccgga gaagccattg gagtgaaaaa cggaggcgta ctgcagcagc 58741 cgttatatgc acttactgta aaggccaagc caaaagccat tccgcaaacg attgaggctg 58801 atatttcaag cctcgatgta aatgaagtac tgacgattgc ggatttgcct gctggcggtg 58861 actactcctt taatcatgaa tcagatgagg ttgtggcttc aatccttcct ccgcagcagc 58921 aggaagcagc tgaggtcgat gaagaggaat ctgccgatgc tcagcctgaa ggtgaaaacg 58981 aacaataata gcttaaggcg taaccctccc gcggttacgt cttttgtgct agaatgagaa 59041 gaattatagc ccgtttatga agacgggagt tatgtgacta agggaggatt cgccatgctt 59101 gtgattgccg gtctcggaaa cccggggaag aactatgaaa atacacggca taatgtcgga 59161 tttatggtga tagatcagct tgcaaaggaa tggaatatag agctgaatca aaataaattt 59221 aacggattat acggaaccgg atttgtttcc ggcaaaaagg ttctacttgt taaaccgctt 59281 acatatatga atttatcagg agaatgtttg cggcctttaa tggactacta tgatgtcgat 59341 aacgaagatt tgacagtcat ttacgacgac cttgaccttc cgactggcaa gatccgttta 59401 agaacgaaag gaagcgccgg agggcacaat ggcatcaaat cactgatcca gcatcttgga 59461 acgtccgagt ttgaccgtat ccgcatcgga atcggccggc ctgtaaacgg catgaaggtc 59521 gttgattatg tgttaggctc ctttaccaag gaggaggcac ctgagatcga agaagcggtt 59581 gataaatctg tgaaggcttg tgaggcttct ttgagtaaac cgtttttaga agtcatgaac 59641 gaatttaacg caaaggtata aaatgtaaca acaaagtcca tactacacca aaatgacttt 59701 ttcatcagga ggacccttgt atggctttgc attattattg tcgtcattgc ggagtgaaag 59761 taggcagtct cgaatcttca atggtatcga cagactcact tggatttcag cacttaacaa 59821 atgaggaaag aaacgatatg atttcttata aagaaaatgg agatgtccat gttttgacga 59881 tatgtgaaga ctgccaagag gcgcttgacc gaaatccgca ttaccacgaa tatcacacat 59941 ttattcaata aaaagctttg gtgtagacac tagaccaaag cgtttttctg ttctcgcagg 60001 aaacagagag gaggggccat atggacaaca ttcaaacctt tataaaagaa agcgatgact 60061 ttaaatccat catcaacggt ttacacgagg gcctgaagga acagctgctc gcgggtctgt 60121 cgggttccgc gcgttctgtt tttacttctg ctctggctaa tgaaacgaat aagcctatct 60181 ttctcatcac ccataactta tatcaagccc agaaagtaac agatgatctg acttcacttc 60241 tagaggatcg gtctgtcctt ttgtaccccg tcaatgaact catttcatca gaaatcgcag 60301 ttgcaagccc tgaattgcgg gcgcagcgat tagatgtcat taatagacta acgaatggag 60361 aagcgccaat tgtcgttgct ccggtagctg caatcagaag aatgctgccg cctgttgagg 60421 tgtggaaaag cagccagatg ctcattcaag taggccatga tattgaacct gaccagcttg 60481 cctcacggct ggtagaggta gggtatgagc ggtctgatat ggtttctgcg cccggggaat 60541 tcagtattcg cgggggaatc attgacattt atccgctgac ttcagagaat ccggtgagaa 60601 ttgaactttt tgacaccgag gtggattcaa tccgcagctt taattcagat gatcagcggt 60661 caattgagac ccttacctcg atcaatatcg gtcccgcgaa ggaattaatt atcagaccgg 60721 aagaaaaagc gcgggcgatg gagaaaatcg atagtggtct tgccgcgagc ttgaaaaaat 60781 taaaggctga caaacaaaaa gaaatacttc atgcgaatat ttctcacgat aaagaacgct 60841 tgtctgaagg ccagacagat caggagctcg tgaagtatct ctcatatttc tatgaaaagc 60901 ctgctagttt actagattat acacctgata atacacttct gattttggat gaagtcagtc 60961 ggattcatga gatggaagaa cagcttcaaa aagaagaagc ggagtttata acaaatcttc 61021 ttgaggaagg gaagattttg catgacattc gtttgtcatt cagcttccaa aaaatagtgg 61081 ctgagcaaaa acggcctctg ctgtactact ctttattttt gcggcatgta caccatacga 61141 gcccgcaaaa tatcgtcaat gtgtcaggcc ggcaaatgca gagtttccat ggccaaatga 61201 acgtgcttgc gggcgaaatg gagcgtttta aaaaatcaaa tttcactgtt gtgttcttag 61261 gagcaaacaa ggaacgtacg cagaaattgt catctgtttt ggctgattat gatatcgagg 61321 ccgccatgac agacagcaaa aaagcgcttg ttcagggaca ggtctatatc atggaaggcg 61381 agctccaatc gggatttgag ctgccgttaa tgaagcttgc cgttatcacg gaagaagaac 61441 tgttcaaaaa ccgtgtaaag aagaagccgc gaaaacagaa gcttaccaat gcagagcgca 61501 tcaaaagcta ttctgagctt caaattggag attatgtcgt tcatattaat cacgggatcg 61561 gaaaatacct ggggattgaa actcttgaaa tcaacggcat tcataaagac tatttaaata 61621 tacattatca gggcagtgac aagctttacg tccctgtaga acaaattgat caggtccaaa 61681 aatatgttgg ctccgaagga aaagagccaa agctgtataa attaggcgga agtgaatgga 61741 agcgggtcaa gaaaaaagta gagacatccg ttcaggatat tgctgatgac ttaattaagc 61801 tgtatgccga aagagaagcg agcaagggct atgcgttttc tcctgaccat gagatgcagc 61861 gtgaattcga atcggctttc ccttatcaag agactgagga tcagctccgt tctattcacg 61921 aaatcaaaaa agacatggaa agagaacgtc cgatggaccg cttgctgtgc ggagatgtgg 61981 gctacggtaa aacagaggtt gccatacgtg ccgcgtttaa ggcgatcggt gacggaaagc 62041 aggtagctct gctcgttccg acaaccattt tggcacagca gcactatgaa accataaaag 62101 agcgcttcca ggactatccg attaatatcg gccttctcag caggttcaga acgagaaaag 62161 aagcaaacga aacaatcaaa gggctgaaaa atggaacggt tgatatcgtc atcgggacgc 62221 atcggctgct atcaaaggat gtcgtgtata aagacttagg gctcctcatc attgatgaag 62281 agcagcgttt cggtgtaacc cataaagaaa agatcaagca aataaaagcc aatgttgatg 62341 tattaacgtt aacagcaacg ccgattccgc gtacgctgca tatgtctatg cttggcgtaa 62401 gggacctttc agtcatcgag actccgccgg aaaatcgctt ccccgtacag acgtatgttg 62461 tggaatataa cggcgctctt gtcagagagg cgattgaacg tgagcttgca cgcggaggcc 62521 aggtctattt cttgtacaac cgggtagagg acattgagcg gaaagcggat gaaatttcaa 62581 tgctagtccc tgacgcgaag gtagcatatg cgcatgggaa aatgacagaa aatgaattag 62641 aaaccgttat gctaagcttc cttgaaggag aatcagacgt tctcgtcagc acaaccatta 62701 tcgaaactgg cgtggacatc ccaaacgtca atacgctgat cgtatttgac gccgacaaga 62761 tgggactttc tcagctttac cagctgcggg ggcgtgtcgg ccgttctaac cgtgtggcgt 62821 atgcgtactt cacgtatcgc cgggataaag tgctgacaga agtggctgaa aaaaggctgc 62881 aggctattaa agaattcaca gagttaggtt ccggttttaa aatcgcaatg cgtgacttaa 62941 cgattcgcgg agccgggaat cttcttggtg cccagcagca tggcttcatc gattcggtcg 63001 gatttgacct ctattcacaa atgctgaagg aggccattga ggagcgtaaa ggagacacag 63061 cgaagacaga gcagtttgaa acagaaattg atgtcgagct tgatgcgtat attccggaaa 63121 cttatattca agacggcaaa cagaaaattg atatgtataa acgcttcagg tctgtggcga 63181 caatcgaaga gaagaatgag cttcaagatg aaatgatcga ccgctttgga aactatccaa 63241 aagaagtcga atacttgttt actgttgcag aaatgaaagt ctatgcgaga caggaacgtg 63301 tcgagctgat taagcaggat aaagatgctg tcagattgac gatttctgaa gaagcaagtg 63361 ctgaaattga cgggcagaag ctgtttgagc ttggcaatca atatggcaga caaatcggac 63421 tgggaatgga agggaaaaaa ctcaaaatct ccatacagac gaaaggccgt agtgctgatg 63481 aatggctcga caccgtgctg ggcatgctga agggcttaaa agatgtgaaa aagcaaacca 63541 tttcatcaac gtaaattttg ttactctctg gtgtatatta catttgatgt gacggatact 63601 aatttcaagc gaggcggaag gtacataaag taactgcttt aggtctttcc cacatgtata 63661 taccatcaaa tgaaagagag gcaccagaga tgaaagcaac cggtatcgta cgtcgtattg 63721 atgacttagg tcgggtcgtg attcctaaag aaattcgaag aactctgaga atcagggaag 63781 gcgatccgct tgagattttt gtagatcgtg acggagaagt gattttgaaa aagtactctc 63841 cgatcagtga gcttggagac tttgcaaagg agtatgcaga cgcgctttac gacagcctcg 63901 gccattcagt gctgatttgt gatcgtgatg tatatattgc cgtgtccggc agctccaaaa 63961 aagattactt aaacaagtca atcagcgaaa tgctggaaag aacaatggat cagcgcagct 64021 ccgtgcttga gagtgatgcg aaatcagtac agcttgtgaa tggaattgat gaggacatga 64081 attcttatac tgtaggccca attgtggcga acggtgatcc gataggtgct gtggtgatct 64141 tttcaaaaga tcagacaatg ggcgaagtag agcataaagc cgttgaaaca gcagctggat 64201 ttttggctcg tcaaatggaa cagtaggtct tattcctttc ttcgaaaata ggtatgtaaa 64261 gaacagctct ccttgggacg ctgttctttt tcatgcgtgc cgaaaaagga atccaagggt 64321 tgggatgtgg tataataacc tcgtttttat ttgtgccgcg gtaatacgtg aaccgtattg 64381 cccctgacgt tgggaaggag cttttggatg gacgattcaa taggcgttaa acggcattgg 64441 atttggcagg gggcttttgt tttaattctg gcaggcgtca tcacaaaaat tttaagcgct 64501 gtttacagag tcccgtttca aaacattgtc ggcgatgttg gattttatat atatcagcag 64561 gtatacccct ttcttggtat tgcggtcatg ctgtccacat caggatttcc agtcattatt 64621 tcaaagctga tgaatgatta tagtgaaaaa aatcatcaca ccatattaaa aatatcagcg 64681 ttgtttttgt ctttaatcgg tattttatta tttctttgtt tatatctggg tgctgttcct 64741 attgcactct ttatgggaga ttcgcatcta gccgtgttaa ttcaagtggc cgcatacgcg 64801 tttctgcttt tcccatttgt cgcgttgcta agaggcggtt ttcaggggcg gcacgaaatg 64861 ctcccttcag ccttatcaca gatgacagag cagtttctgc gtgttgcggt gctcttgggt 64921 ttatcatttt ggctcgtgaa aaagggagcc tcgctttata ctgcgggagc ggcagccgct 64981 tcaggctctc ttgccggaag tttggttgca ttgataatac tggggttttt ttggttcaaa 65041 acgaaaagag acaaccaaac ggataggcaa aacgaaaatg tcatcacaac aaaagaattg 65101 acgaaaaaac tgcttttata ttcggtcaca atttgtgtaa gcagtttgct gcttttgttt 65161 atccagcttg ttgatgcttt gaatttatat gcattgcttt cgggtggtga ggcaagcgaa 65221 gaagcaaaat gcctaaaggg gatctatgat cggggacaac ccttgttgca gctcggttca 65281 gtttttgccg taagcattgc gacgtcactc gttccgtata tttctatggc tgtaaaaaac 65341 aaagagctga agatcatgaa agaaaaaatc acgtcatctt tgaaactatg ccttgtgctc 65401 ggtacaggcg catcggctgg gttgatttgc attctaaagc cggtaaatat catgctgttt 65461 caaaatggag aagggacagg tgcgttacaa gtatttagct gctccatttt gtttgcatcc 65521 ttggcggtaa cggcagcggc agtcttacag ggagcgggat acacagtttt tcctgcgata 65581 gcggtgggcg cgggtgttgc ggtgaaatgg gtgttaaaca cacttttggt tccgcgctat 65641 gggattgaag gcgcatcgct tgcgacagcg gcttcctttg cggctgtcgc cggccttaac 65701 ttgtatcagc ttcggcaaaa ggaatggctc gataagctta gaggcgtttt gattccgatt 65761 attggatctg ctcttttgat gtcagctgtt ttgcttgcgt atacgcgtct ctggactttc 65821 ttgtttcctg caacaggaag aggagcggct gtgattgaga gtctttctgc tgttgccatt 65881 ggtggcgcgg tgtttattta ttgtatgatg agattgggaa tatttacaga tgaagagctg 65941 aacagtgtgc cattcggcag caagttaagc aaattcatga gaaggagaga acaaaatggc 66001 gggtaaaatt acagtcgtcg gacttggtgc cggagacatg gaccaattga caattggtat 66061 acacaagctg ctgacgaagg cagatacgct gtatgtcaga accaaggatc atcctttaat 66121 tgaggagctt gaaaaagaaa cgaagaacat ccgtttcttt gatgatatat atgagaaaca 66181 tgatcagttc gaggcggtat atgaagaaat tgcagatatc ctctttgaag cggcgcggcg 66241 tgaggacgtg gtttacgctg tgccgggaca cccttttgtc gcagaaaaaa cagttcagct 66301 gctgacggag cggcaggaaa aggaaaacgt tcaagtgaaa gtcgcggggg gacaaagttt 66361 ccttgatgcc acattcaatg tcttgcaaat tgacccgatt gaaggttttc aatttgtgga 66421 tgccggcaca ttgtccgcgg atgagcttga gctcagacat catctgatca tatgtcaggt 66481 ttacgaccaa atgacggctt ctgaagtcaa gctgacattg atggagaagc tgcctgatga 66541 ttatgaggtc gtcattgtga ctgcagcagg cagccgtggc gaggagatca ggacagtgcc 66601 attatttgag ctggaccgca atgtcgcttt gaacaactta acaagtgtgt atattccgcc 66661 gattaaagaa gagaagctgc tttatcacga attctccacg ttccgaagca tcatcagaga 66721 gcttcgcgga cctaatggat gtccgtggga taaaaagcag acgcatcagt cattaaagca 66781 gtacatgatt gaagaatgtt atgagcttct cgaagctatt gacgaagaag acacagacca 66841 tatgatcgaa gagcttggcg acgttttgct tcaggtcttg cttcacgcgc aaattggtga 66901 agatgaaggt tatttcacaa ttgatgatgt cataaaagga atcagtgaaa aaatggtccg 66961 aagacatccc catgtgttta aagatgttaa ggttcaggat gaaaacgatg ttttagccaa 67021 ttgggaagat ataaaaaagg ccgaaaaaaa tacatctgaa tcatcattac tagacagcgt 67081 accgaaaacc cttccagctc tttcgaaagc agctaaattg cagaaaaaag cagcgaaggt 67141 cggttttgac tgggaagacg tcagcgatat ttgggaaaag gtaagtgagg aaatgaagga 67201 attttcttct gaggtttctg aagctcctca cgaacacaat cttaaagctg agtttggcga 67261 cattttgttc gcgctggtga atgtagcccg cttctacaaa atagagccag aggaagcgct 67321 gaccatgact aatgacaaat tccggagacg gttctcgtac attgaggaaa cagcgaagga 67381 agagggagtc gagttggctg atatgtccct tgaggacatg gacaaactgt ggaatgaagc 67441 aaaagaaact gagaggagat catagatatg agattagata aatttttgaa agtatcacgg 67501 ctgatcaaac ggcgtacact agcgaaggaa gtagctgacc aaggacgaat ctctattaac 67561 ggaaaccaag ctaaagctag ctctgacgta aaaccgggag atgaactaac ggtccgcttc 67621 ggccaaaagc ttgtaacggt tcaagttaat gaattgaaag acacgacgaa aaaagaagaa 67681 gctgcaaaca tgtacacgat tctaaaagaa gaaaaactcg gcgaataggc ttgttctaaa 67741 aaaacccccc acctcataca atgcagtaat aatgctaaaa gtatcgagga tatgggggct 67801 gaatagatga attcatatta tgatcaaaaa ggttcttcgt ctgttccgga acagcatgat 67861 gtgacaatga aaggccggaa gcatttagat atttctgggg ttaagcatgt ggagagtttt 67921 gataacgaag aattcctgct ggaaacggtg atgggaatgc tctccgtcag aggccaaaac 67981 ctgcagatga aaaatcttga tgtggaaaaa gggattgttt cgattaaagg cagggtattt 68041 gatttagtgt acttagacga acaacaaggg gataaagcta aagggttttt tagcaagttg 68101 tttaaatgac gctgacgaca caattctata caatgctagc gatgtccggt atgggtctct 68161 ggcttggtgc ttcgcttgat acataccggc tctttgtcat tcgtgccaaa acagccagat 68221 ggctattatt tattcatgat attcttttct ggattatgca agggctgctt ttcttttatg 68281 tcttgcttca tgtaaatgag ggagaattca ggatttacat ctttttagcg gttctgctgg 68341 gcgttgcgac gtatcagagc ctttgcaaac gaatctatat aaaaatactg aaattcgtca 68401 tttaccttgt tgtttctgtt tatcaattct tcaaaaaact cattcagcac gtgttatttc 68461 gtcctattgt gtggacatgc ggagcgatca tctggctggc ggcattttta ttcaagaaaa 68521 catacagcct gataggtttt ctcctgctgt gtctatataa aatagtcatg gttctgtgtt 68581 ttccgatccg ttttatcgcg aaacaatgtt tgaaacttct tcctgtgaaa atgcgtctaa 68641 cttttagacg ttattttgaa aaaggtgcag gatttctcaa aaagaagaag aaactattga 68701 taaccataag aacgaccatc acacggtttt tgaagagatg aaaggaggac cgtctggttt 68761 gaatttttcc agggaacgaa cgataactga aatacaaaac gactataaag aacaagtaga 68821 acggcaaaat cagctgaaga aacgaagacg caaagggctg tacagacggt taactgtatt 68881 cggcgcccta gtattcctga cggcaattgt gctggcaagc tctgtatggt cccaaacatc 68941 ttcccttagt gcaaaagaag aaaagaaaga acagcttgaa aaagaactga aaagtttaaa 69001 gacaaaacaa acggatttaa aagaagaaat atccaaattg aaggatgagg attacgtcac 69061 agagcttgcc agaagggact tattcatgtc tggagacgga gaaattatct tcaatgtgga 69121 gaagaagagc aagtagcctt gttgacactt aaatttttat ttaggtataa ttaagcaaac 69181 gatcttttta taagcctaag gaggagcact ttttttatgt cgattgaagt tggcagcaag 69241 ttgcaaggga aaattacagg tattacaaat tttggagcat ttgttgaatt gcctggaggc 69301 tcaaccggtc tcgttcacat tagtgaggta gctgataatt atgtcaaaga cattaacgac 69361 cacttaaaag tcggcgacca agttgaagtg aaagtcatca acgttgaaaa agacgggaaa 69421 attggtttat ctattaaaaa agctaaagac cgtccgcaag ccagacctag aaatgatttc 69481 cgtccgaaag aatcttttga acagaaaatg aataagtttt taaaagacag cgaagatcgc 69541 ttgtcatctt taaaacgcaa tacggaatca aaacgtggag ggcgcggagc aagaagagga 69601 taacttgctg ctttctataa aataaatgaa gcatccgttc atcccgacgg atgctttttt 69661 attatcctca ttctctttaa gagtcagaaa attacaacat taaagtttct gttgacgaaa 69721 gagacaaacc tttgtattat ataacttgtg cttagaagca caaaacaata tggcggtgta 69781 gctcagctgg ctagagcgta cggttcatac ccgtgaggtc gggggttcga tcccctccgc 69841 cgctaccata tttgtttggc ccgttggtca agcggttaag acaccgccct ttcacggcgg 69901 taacacgggt tcgaatcccg tacgggtcat cctaacaaat cggtttctct tgcagaagcc 69961 gatttttttc atttttagac aacattccgg aaattctttt cataaacgaa tatcaaggca 70021 gaaaccgtcg aagatttctt tggtattgtt accttctttt gacaaaatcc tatctgtgct 70081 ttcgctataa tgacaggcaa cgaatataac aggtgggaga tgagaggaat ggaaaaagca 70141 gaaagaagag tgaacgggcc aatggcggga caagctttgg aaaaactcca atcgtttttt 70201 aacaggggca cgaagctggt gactcatcat ttgcattcac tgtttttcta taaaggattc 70261 atttatgttg tcatcggatt tttgcttgga cgggctttca tattatccga ggtgcttcct 70321 ttcgcacttc ctttctttgg agcgatgctt cttatcagaa gagacaaagc gttttatgcg 70381 gttttggctg tgcttgcagg tgcgctgacc atatctccaa agcactcatt gctcatactg 70441 gcggcattgc tggcattctt cgtattttct aaagtggctg ccttcattac cgacgatcgt 70501 gttaaagcgc tcccgattgt cgtgttcttc tccatggctg cagcaagagc cgggtttgtt 70561 tatgcccaaa atggcgtatt tacaacctat gattatgtaa tggctatcgt tgaggctgga 70621 ctatcgttta tcttaacact gattttcctt cagagccttc cgatttttac tgtgaaaaaa 70681 gtgaaacaat cattaaaaat agaggaaatc atttgcttta tgattcttat tgcctctgtt 70741 ttaacggggc tggctggctt gtcctaccaa gggatgcagg cagaacatat attggctcgt 70801 tatgttgtgt tgagtttttc ctttattggc ggagcaagca tcggctgtac ggttggggtt 70861 gtgaccggcc tgattcttgg cttggcgaat atcggaaacc tatatcaaat gagtctgctt 70921 gctttttccg gtttattggg cggtttgctg aaggaaggga aaaaagcggg tgcagcaatt 70981 ggtttgatcg ttggatcact tcttatatct ttatatggtg aaggctctgc cggtctgatg 71041 acaacgctct atgagtcatt aatcgcagtc tgcctgtttt tgctcacacc tcaatctatt 71101 acgaggaaag tggcgagata tattccggga actgtcgagc atcttcaaga gcaacagcaa 71161 tacgctagaa aaatccgtga tgtcactgct cagaaggtag accaattctc caatgtattt 71221 cacgcgctgt ctgaaagctt tgcaaccttt tatcaagcat cagacgaaca gacagatgac 71281 agcgaagttg atctgttctt aagcaaaatc acggagcatt cctgccagac gtgctacaag 71341 aaaaacaggt gctgggtaca gaactttgat aaaacatatg acttaatgaa acaagttatg 71401 cttgaaacag aggaaaaaga atatgcatca aaccgaaggc tgaaaaaaga gtttcaacag 71461 tattgttcta aatccaagca ggttgaagag ctgattgagg atgagctcgc acatcatcat 71521 gcccatttga cactcaagaa aaaagtccaa gacagcaggc gccttgttgc tgaacagctt 71581 ttaggcgttt ctgaggttat ggccgacttt tctcgggaaa taaaaagaga gcgagaacaa 71641 cactttctgc aggaagagca aatcatagaa gcgcttcagc atttcggaat tgagattcag 71701 catgtcgaga tctatagtct tgaacaagga aatatcgata ttgaaatgac cattccgttc 71761 agcggacatg gagaaagtga aaaaatcatt gctcctatgc tttctgacat tctggaggaa 71821 caaattcttg tgaaagccga acagcactct ccgcatccga atggatacag ccatgtcgcc 71881 tttggatcaa caaaatcata cagggtgtcc acgggagctg ctcacgctgc gaagggcggc 71941 ggccttgtct ccggtgacag ctacagcatg atggagcttg gagccagaaa atatgctgca 72001 gcaatcagtg acggaatggg caatggcgca agagcgcact ttgaaagcaa tgaaacgatc 72061 aagcttcttg aaaaaatcct tgaatcgggc attgatgaaa aaatagcaat taaaacgatc 72121 aacagcatac tgtctctaag gacaactgac gaaatatatt ccacgcttga cctatctatt 72181 atcgatcttc aagatgccag ctgtaaattt ttgaaggttg gatcgacgcc cagctttatc 72241 aaacggggtg accaggtcat gaaagttcaa gcgagcaatc tgccaatcgg tattattaat 72301 gaattcgatg tggaggttgt gagtgaacag ctgaaagcgg gtgacctctt aattatgatg 72361 agtgatggca tttttgaggg gcctaagcat gtggaaaatc acgacttatg gatgaagcgt 72421 aaaatgaaag ggttgaaaac aaatgacccg caggagattg ccgatttgct tatggaagaa 72481 gtcatccgca caagatccgg ccaaattgag gacgatatga ctgttgttgt cgtccggatt 72541 gatcacaata caccgaagtg ggcatccatt cctgttccgg caatctttca aaacaaacaa 72601 gaaatttcat aacgcttccg tataaatcaa atttcttctg gcgaagatgg gaatatatga 72661 atctgagaat cctcgtattc tccaggagga atgaatgtga acaacggaca tttaaatcaa 72721 attttgctga taacggatgg ctgctcaaac catggggaag acccgcttgc aatggctgct 72781 tttgctaaag agcaggggat tacggtaaat gtcattggta taatggaaga aaatcaaatt 72841 gaccctgagg caatgaagga agtcgaaggg attgcacttg ccggaggagg cgtgcaccaa 72901 gtcgtttatg catctcagct ttcacaaact gttcaaatgg taacaaagaa agcgatgacg 72961 caaaccttac aaggtgtagt caatcaagaa ctgaaacaga ttctcggaaa gaatgtggaa 73021 atggaagagc tttctccgga aaaacgcggc gaagtcatgg aagtggtaga cgagcttgga 73081 gaaacggtgc atcttcaggt tttggttctt gttgatacaa gtgcaagtat ggcgccaaag 73141 cttccaacag taaaagaggc gctgattgat ttgtctgtaa gcctcaattc ccgaattggg 73201 aataacgaat ttgcgatgtg tatatttccc gggaaaaaac aagaggtcga gcttgtgctg 73261 aactggacac cgaagctgca atctctttcc acactctttg caaagctttc gacaggcggc 73321 atcacgccga caggtccggc gattcgtgaa gcgacactgc agtttgaaaa aatacgctca 73381 agaaggggca tgctggcaga tgatgaacga cgctttgacg agtttggcat gtagcctcaa 73441 gccgggtacg acaatcaaag gcaagtggaa tggaaacact tatacattgc gtaaacagct 73501 tggtaaaggg gccaatggaa ttgtgtattt ggcagaaaca tcagatggac atgttgcctt 73561 aaaggtgagt gatgacagcc tgtctattac ttctgaagtg aatgtcttga aatctttctc 73621 aaaggcccag tccgttacga tggggccttc tttttttgat acggatgatg cctatattcc 73681 cagtgccaat acgaaagttt cattttatgc aatggaatac ataaaagggc cgctgctttt 73741 gaagtatgtc agtgataaag gagcagagtg gataccggta ttaatgattc agctgttatc 73801 cagcttatcg gtgcttcacc agcaaggatg gatattcggc gatcttaaac ctgataatct 73861 gatcgtaact ggtccgcccg caaggatccg ctgcattgat gtgggcggca cgacaaagga 73921 aggccgggcg ataaaagagt atacggagtt ttatgacaga ggctattggg ggtatggaac 73981 aagaaaggca gagccatcct atgatctgtt cgcagttgcc atgattatga tcaacagtgt 74041 gcataaaaaa gaatttaaga aaacgaacca gcccaaagaa cagcttaggt ctctcatcga 74101 aggaaacccg ctgcttcaaa agtataaaaa agcgcttttt tcagccttga acggagatta 74161 tcaatccgca gatgaaatga aaaaggatat gctagacgcg gggcaaaaag cagcacaaag 74221 aaaacagcct ataaaagcat caccgcagcc tgccacacga caaagacagc aaaaaccgcg 74281 ccaaggaaaa ataacgaaga cgcgatatac cccaaaacag aaaccggcta agtcgggggg 74341 gttatttgaa acaacgctta tcgtgatcag tgttttagcg ctttatttcg cctatattat 74401 ctttttctta atctgaatgg tgcaaactgc agagcctatg cttcttcttt gcttggaggg 74461 gttgaaagtg ttaggatatg aatatcttta aaatacctgc tcattgtgag gaggacattg 74521 tgaaaagtgt caaagatttt ttaaacaaac acaatcttac gttaaaaggg gcgacaatca 74581 ttgtaggcgt ttccggcggt ccggactcaa tggctcttct tcacgcgttg catacgttat 74641 gcggccgttc agcgaatgtt attgcagctc acgttgacca tcggttcaga ggtgcggaat 74701 ccgaggagga catgcgtttt gtccaagctt attgtaaagc tgaacagctc gtgtgcgaaa 74761 cggctcaaat caatgtaacc gcatatgcac aggaaaaagg actcaataag caggctgcag 74821 cacgcgattg ccgctaccag ttttttgagg aaatcatgtc gaagcaccaa gcggactatc 74881 tggctcttgc gcatcatggt gatgaccagg ttgaaacaat gcttatgaaa ctggctaagg 74941 gtacgcttgg aacgggactt gcgggaatgc agccggttag acgttttggg acagggcgga 75001 tcatcaggcc gttcttaacc attacaaagg aagagatcct tcactattgc catgaaaacg 75061 gcttgagcta ccggacggat gaaagcaacg ccaaagatga ctacacaaga aacagattca 75121 gaaaaacagt gctcccgttt ttgaagcagg aatctccgga tgtgcataaa aggtttcaga 75181 aagtgagtga agcactgacg gaagatgagc aattcttaca gtcattaacg aaagatgaaa 75241 tgaataaagt aatcacaagc cagtctaata catcagttga aatcaattcc tctcaattgc 75301 ttgccctccc gatgccttta caaagaagag gagttcaact aatattaaac tatctttatg 75361 aaaacgttcc atcatccttt tcagcccatc acattcagca gtttctcgat tgggcggaaa 75421 atggcggtcc ttcaggagta ctggactttc cgaaagggct gaaggtggtc aaatcatatc 75481 agacatgttt gtttacattt gaacaatggc agtgcaaaaa tgttcccttt gaataccaaa 75541 ttagcggagc tgctgatgaa acggcagtgc tccctaatgg atatctgata gaggcaaggc 75601 attatgcgga ctcgcctgaa gaacatggga atgctgtttt tatcacaagt gaaaaaaagg 75661 tgcgatttcc cttaacaatc cggacgagaa aagctggaga ccggatcaaa ctaaaaggga 75721 tgaacggctc aaaaaaggta aaggatatat ttattgataa gaaattgcct ctccaagaaa 75781 gagacaactg gccgattgtg acggacgcaa gcggtgaaat tatctggata cctggcttga 75841 aaaaatcaat ttttgaagat cttgtgattc caaacagcga ccgcattgta ttacaatata 75901 gacagcatga aaagtgtagg gggcaagcaa aatcatgatg aaacatgata tcgagaaagt 75961 actgatctca gaggaagaga tacaaaagaa agtaaaagag ttaggtgcag aattaacgag 76021 cgagtatcaa gatacatttc cgttggcaat cggtgtgtta aaaggagcac ttccttttat 76081 ggcggatctt atcaagcata ttgatacata tttggaaatg gatttcatgg atgtatcaag 76141 ctacggaaat tctacggttt cttctggaga agtaaaaatc attaaagatt tggatacatc 76201 tgtagagggc cgggacatct taattattga agatatcatc gacagtgggt taaccttaag 76261 ttatctcgta gagctcttcc gataccgtaa agcaaaatca attaagattg ttaccctttt 76321 ggataaaccg agcggaagaa aagcggacat caaagcagac tttgtcggtt ttgaagttcc 76381 tgacgcgttt gtagtgggtt acggacttga ttatgctgag cgctatcgca atctgcctta 76441 tatcggagtg ttaaaaccgg cagtttatga aagctgatcg gcagcctgct tccgagatgg 76501 ttattgtttg tattggaatg attttctatg gtactattga acatagttgt gcttactgtg 76561 ggaggaggta aggaatgaat cgggtcttcc gtaataccat tttttattta cttattttat 76621 tagtagtaat cggggttgtg agctacttcc agacctcaaa tccgaaaaca gaaaatatgt 76681 cgtacagtac gttcatcaaa aacctggatg acgggaaagt tgatagcgta tcggttcagc 76741 ctgtcagagg tgtttatgag gtaaaagggc agctgaaaaa ctacgacaaa gatcaatact 76801 ttttgactca tgttcctgaa ggaaagggag cagaccagat atttaacgct ttgaaaaaga 76861 cagacgtaaa ggttgagccc gcgcaagaaa caagcggatg ggtgacgttc ctgacgacca 76921 tcatcccatt tgtcattatc tttattctgt ttttcttcct gctcaatcag gctcaaggcg 76981 gcggcagccg tgtcatgaac tttggcaaga gtaaagcgaa gctgtataca gaggaaaaga 77041 aacgcgtcaa atttaaagac gttgcagggg ctgacgaaga aaagcaagaa cttgttgaag 77101 ttgttgagtt tctgaaagat ccccgcaagt ttgccgagct cggcgccaga ataccgaaag 77161 gcgtgctttt agtcggacct ccgggtaccg gtaaaacatt gcttgccaag gcttgtgcag 77221 gagaagccgg cgtacctttc ttcagcatca gcggatctga tttcgttgaa atgtttgtag 77281 gggtcggtgc ttcccgtgtg cgtgacttgt ttgaaaatgc gaaaaagaat gcgccttgtt 77341 tgatcttcat tgatgaaatt gacgcagtcg gacgccagcg tggcgctggt ctcggcggtg 77401 gacacgatga acgtgaacag acgctaaacc aattgcttgt tgaaatggac ggattcagcg 77461 ctaatgaagg aattatcatc attgctgcga cgaaccgtgc ggacatcttg gacccagcct 77521 tacttcgtcc gggacgtttt gaccgtcaaa tcacagtgga ccgcccagat gtcattggcc 77581 gtgaagctgt attgaaagtc catgcgagaa acaaaccgct ggatgaaacg gttaacctaa 77641 aatcaattgc catgagaaca ccaggcttct caggcgctga cttagaaaac ctcttgaatg 77701 aagctgcgct tgtagcggct cgtcaaaaca agaaaaaaat cgatgcgcgt gatattgacg 77761 aagcgacgga ccgtgtaatt gccggacccg ctaagaagag ccgcgttatc tccaagaaag 77821 aacgcaatat cgtggcttat cacgaaggcg gacacaccgt tatcggtctc gttttagatg 77881 aggcagatat ggttcataaa gtaacgattg ttcctcgggg ccaggctggc ggttatgctg 77941 ttatgctgcc aagagaagac cgttatttcc aaacaaagcc ggagctgctt gataaaattg 78001 tcggcctctt gggcggacgt gttgctgaag agattatctt cggtgaagtc agcacagggg 78061 cgcacaatga cttccagcgt gcgacgaata ttgcaagacg aatggttaca gaattcggta 78121 tgtcagaaaa actgggaccg ttgcaatttg gacagtctca gggcggtcag gtattcttag 78181 gccgtgattt caacaacgaa cagaactaca gtgatcaaat cgcttacgaa attgatcagg 78241 aaattcagcg catcatcaaa gaatgttatg agcgtgcgaa acaaatcctg actgaaaatc 78301 gtgacaagct tgaattgatt gcccaaacgc ttctgaaagt tgaaacgctt gacgctgaac 78361 aaatcaaaca ccttatcgat catggaacat tacctgagcg taatttctca gatgatgaaa 78421 agaacgatga tgtgaaagta aacattctga caaaaacaga agaaaagaaa gacgatacga 78481 aagagtaatt cgctttcttt ctaaaaaaac tgccggctga cgctggcagt ttttttatgt 78541 aaatgattgg ctcagctgcg gcttttacaa tcatccaatt ctggtatcga tttgtttaca 78601 aatgagccgc tgatcgtgta tggtattgta gaatgtttgt aaaaagtaaa gtagagaaac 78661 tattcaaaag tggtgataga ggttgttact ggttatcgat gtggggaaca ccaatactgt 78721 acttggtgta tatcatgatg gaaaattaga atatcactgg cgtatagaaa caagcaggca 78781 taaaacagaa gatgagtttg ggatgatttt gcgctcctta tttgatcact ccgggcttat 78841 gtttgaacag atagatggca ttattatttc gtcagtagtg ccgccaatca tgtttgcgtt 78901 agaaagaatg tgcacaaaat actttcatat cgagcctcaa attgttggtc caggtatgaa 78961 aaccggttta aatataaaat atgacaatcc gaaagaagta ggggcagaca gaatcgtaaa 79021 tgctgtcgct gcgatacact tgtacggcaa tccattaatt gttgtcgatt tcggaaccgc 79081 cacaacgtac tgctatattg atgaaaacaa acaatacatg ggcggggcga ttgcccctgg 79141 gattacaatt tcgacagagg cgctttactc gcgtgcagca aagcttcctc gtatcgaaat 79201 cacccggccc gacaatatta tcggaaaaaa cactgttagc gcgatgcaat ctggaatttt 79261 atttggctat gtcggccaag tggaaggaat cgttaagcga atgaaatggc aggcaaaaca 79321 ggaaccaaag gtcattgcga caggaggcct ggcgccgctc attgcgaacg aatcagattg 79381 tatagacatc gttgatccat tcttaaccct aaaagggctg gaattgattt atgaaagaaa 79441 ccgcgtagga agtgtatagg aggtttagta atggattatt tagtaaaagc acttgcgtat 79501 gacggaaaag ttcgggctta tgcagcgaga acgactgata tggtaaatga ggggcagaga 79561 cgccatggta cgtggccgac agcatccgct gcactaggcc gtacaatgac agcttcactt 79621 atgctcggcg ctatgctgaa gggcgatgat aagctgaccg tgaaaatcga gggcggaggt 79681 ccgatcggag ctattgtagc tgatgccaat gccaaaggag aagtcagagc ctatgtctct 79741 aacccgcaag ttcattttga tttaaatgaa caaggtaagc ttgatgtcag acgtgcggtt 79801 ggaacaaacg gaacgttaag tgtcgtaaaa gatttaggtt tgcgcgagtt cttcacagga 79861 caagtagaaa tcgtttcagg agaattagga gatgatttta cttactatct tgtgtcatct 79921 gagcaggttc cttcatcagt gggcgtaggt gtgctcgtaa atcctgacaa taccattctt 79981 gcggcagggg gctttattat tcagctgatg ccgggaacag atgatgaaac aatcacaaaa 80041 attgaacagc gtctatctca agtagagccg atttctaagc tcatccaaaa agggctgaca 80101 ccagaagaaa ttttagaaga agtcctaggc gagaaacctg agattttgga aacgatgcct 80161 gtcagattcc attgcccttg ttcaaaagaa cggttcgaaa cagccatttt aggactaggc 80221 aaaaaagaaa ttcaagatat gatagaagaa gatggacaag ccgaagcagt atgccatttt 80281 tgtaatgaaa agtacttatt tacaaaagaa gagctggaag ggcttcgtga ccaaactacc 80341 cgctaagctc tttagcgggt ttttaatttg agaaaagggg ctgaaagcag gtttgaaatc 80401 aagaacaatc tggaccatta ttttaggggc gctgttggtt tgctgtattg ctgttgcata 80461 tacgctgacg aaatcccaag ccggcgcatc gtcatccggt gagtctattg cgactatcgg 80521 aggcaagagt gtgacaagag aagaatggct gaaagaaatg gaagatcagt atggtaagtc 80581 aacgcttgaa gatatgatca atgtccgagt tgttgagcag ctggctaaaa agaacaaact 80641 taaaatatcc aaaagcgaag ttgatcgtga gtttttgctg attaaagcgg tcaataattc 80701 cttttacgaa gatgaacata cgacggagaa agagtggaaa gaccaaattc gttataatat 80761 cctccttgag gatttgttaa caagggatat cgatatctca aacaaagaat tggaatcatt 80821 ctataataaa aataaggaac tatatcagtt tgatgattcg tatcgaattc ggcacattgt 80881 tgtaaaagat gaagaagaag caagagaagt cctgaaagaa ctgaaaggcg gatcaagctt 80941 tgaagctgtc gctgccgaaa gatctacaga cagatataca tcaccatacg gcggagattt 81001 aggttttgtc acagaggcat cagacaacat tccatcagca tacattgaag aggcgaaaac 81061 actcaaagag gatgaatggt ctcaggaacc aataaaggtc agcaacggat atgccattat 81121 ccagctgaaa gaaaaactaa aggcaagaac gttctcattt gatgaagtaa aggaccagat 81181 cagacggcaa atcgcaatgg atcagctagg cgataaagcg acagttaaga cactttggaa 81241 agaagccgat gtatcttggt tttatgggga aaaaagtact aagtgattga caaaaaattt 81301 tgaaattgat agattatata cataatacca atacaaatag tcggaaattg aggtgtcgag 81361 aatggtacgt gtagcaaact ccattactga attaattggg aatacgccaa tcgttaaatt 81421 aaatcgcctt gcagatgaaa acagtgcgga tgtatatcta aaacttgaat acatgaaccc 81481 tggaagcagt gtaaaagacc gtatcggttt agctatgatt gaagcggctg aaaaagaagg 81541 aaaattaaaa gccggtaata caatcattga accgacaagc ggaaatactg gaatcgggct 81601 tgcaatggtt gctgctgcta aaggattaaa agccattttg gttatgcctg atacaatgag 81661 catggagcgc cgcaaccttc ttcgcgcata tggtgctgag cttgtgctga ctcctggtgc 81721 ggaaggcatg aaaggtgcta ttaagaaagc tgaagagctt gctgaaaagc acggatactt 81781 tgtgccgcag cagtttaaca acccttctaa ccccgaaatt caccgccaaa caacgggtaa 81841 agaaatcgtt gagcaattcg gtgatgatca gcttgacgca tttgtagccg gaatcggaac 81901 gggcggaacg attacgggag cgggcgaagt gctgaaggaa gcataccctt ccatcaagat 81961 ttatgctgtt gaaccgtcag attccccagt gctttcagga ggaaaaccag gcccccacaa 82021 aattcaggga atcggagcag gattcgtgcc ggacatctta aacactgaag tatatgatga 82081 aatcttccct gtgaagaatg aagaagcatt cgaatatgcc cgcagagctg cacgtgaaga 82141 aggaattctc ggaggcatct catcaggtgc ggcaatttat gctgctcttc aagtagcaaa 82201 aaaactcgga aaaggcaaaa aagtattggc catcattcca agtaacggcg aacgttatct 82261 aagcacgccg ctgtaccaat tcgattaaaa aaagccaaaa ctcccggttc gccgggagtt 82321 tttttatatt tcgtgcatca aatatgccat gtctgcgacg aatgttattc ttggaagaga 82381 aattcacttt tttcactaac aacattgctt tacaattaaa aacaagtaaa aaagaaaata 82441 gaggaatgat acaaatggca caacgcagac cggcaggcaa aaaaatacct tttcaaaaag 82501 actcattctt acaacaattt gagaaacttg cgcaatcccg gaaacatcat gtacttctcg 82561 aaagtgcaag aggcggcaga tatagtatag ccggtcttga tccaattgcg actgtgaaag 82621 gaaaagacgg aataactaca attaagcatg gtgatgagat gctgtttaaa gaaggtgatc 82681 cattacgggc cttccacagc tggtttaaaa cactggaaac agaaacgaat catgagttcc 82741 ctgactttca aggcggggca atcgggtttc tcagctatga ttacgcacgg tacattgaaa 82801 attttaaaat gctctcatta gatgatttag aaacaccaga tatttatttt cttgtttttg 82861 atgatatagc agtttatgac catcaagaag agtctctatg gctgattact catgttaatg 82921 gttctgatca ggaaacagcg gatgtgaagc tatctgagtt agagcagatg tggttgactg 82981 agcttcccgc tgtcacttcg cgagagatga agcctgaaac agctggttct ttcgcggcgc 83041 catttaccga ggatgggttc tcacaagctg tagagaaaat caaacaatac attgccagcg 83101 gagatgtgtt tcaagtcaat ctatcaataa ggcagtcaca gtcactgtct gtccacccat 83161 atcaaattta caaaaccttg agagaagtaa atccttctcc ttatatggcg tatttagaaa 83221 cacctgattt ccaaatcatt tgcggatcgc ctgaactgct tgtcagcaaa aagggcaagc 83281 tattagagac gagaccgatt gcgggcaccc gttccagagg gaaaacaaat gaagaagacg 83341 aggcgcttgc aaacgaattg atacacaatg aaaaagaacg cgcggaacat gtcatgctgg 83401 ttgatcttga gcgaaatgat ctgggaagag tatcacgtta cgggtctgtg cgcgtaaatg 83461 aattcatggc aattgaaaaa tactcgcatg tgatgcacat tgtgtctaat gtccaaggtg 83521 aactgcagga tgggtatgat gctgtagata ttattcatgc tgtgtttccc ggaggaacca 83581 ttactggtgc accgaaagta agaacgatgg aaattataga agaacttgag ccgacacgcc 83641 gagggcttta tactggatct ataggatggt ttggatataa tcacgatctg cagtttaata 83701 tcgtcattcg aaccatttat gcaaccggag ggcaggcatt tatgcagtcc ggtgcaggag 83761 ttgtgattga ttctgttccg aagcacgaat acaaggaatc attcaaaaaa gcttttgcga 83821 tgcaaagagc attagagctg agcgaagaag agacaaaaat tagatgaggt gagcggagaa 83881 atgattttaa tgattgataa ctacgattca ttcacgtaca acttggtaca gtatttgggc 83941 gagcttgggg aagagctggt tgtgaaacgc aatgacagca tcacaatcga tgaaattgaa 84001 gaactgtctc cggactttct gatgatatct cccggaccgt gcagccctga tgaggcggga 84061 atcagcctcg aagcaattaa acatttcgca gggaaaattc ctattttcgg tgtatgtctc 84121 ggacatcagt ccatcgcaca agtgttcggt ggtgatgttg ttagggcaga acggcttatg 84181 cacgggaaaa cctcggatat cgagcatgac ggcaaaacca tttttgaagg gttgaaaaat 84241 ccccttgttg cgacgcgata ccactcgctg atcgtaaaac ctgagacgct gccaagctgt 84301 tttacagtaa cagcacaaac gaaagaagga gaaatcatgg ctattcgcca caatgacctc 84361 ccgatagagg gtgtgcaatt tcacccagag tctattatga cctcctttgg gaaagaaatg 84421 ctcagaaatt ttattgagac atatcgcaag gaagttattg cgtgatgata tatgtgaacg 84481 gccggtatat ggaggagaaa gatgcagttc tttctccttt tgaccatggg tttttatatg 84541 ggatcggtgt tttcgaaacc ttcaggctct acgaaggctg cccgtttttg cttgattggc 84601 atatagagag gcttgaacgc gcgcttaagg atctgcaaat cgaatatact gtttcaaagc 84661 atgagatcct tgagatgctg gacaagctgc ttaagctaaa tgatatcaag gatggcaatg 84721 cccgcgtcag actgaacata tcagcgggaa tcagcgataa aggctttgtc gcccagacgt 84781 acgataagcc caccgtttta tgctttgtga atcagctgaa accagaaagt cttcctttgc 84841 aaaaagaagg aaaggtttta tcgatacgga gaaacactcc agagggatcg ttccggttaa 84901 aatctcatca ttatctaaat aatatgtatg cgaaacggga aattggaaat gatccgcgtg 84961 tcgagggaat tttcttaacg gaggatggag ctgttgcaga gggtatcata tctaatgtct 85021 tctggagaaa aggtcgctgt atctatacgc catcgcttga taccggtatt ctggacggcg 85081 tcacgagacg ttttatcata gaaaatgcaa aggatatcgg cctggagctc aaaacgggcc 85141 gatatgagct agaagctctc ttgacagctg acgaagcgtg gatgacgaac tcggttcttg 85201 aaatcatccc gtttactaaa atagaagaag taaactatgg aagccaaagc ggagaagcaa 85261 cctccgctct tcaattgtta tacaaaaaag aaataaagaa catgattcat gaaaagggag 85321 gaagagcatg gcgcagcaca caatagatca aacacaagta atccacacta agcccagcgc 85381 tttatcatat aaagagaaga cgctggtgat gggaatttta aacgtaacgc ctgactcttt 85441 ctcggacggc ggaaaatatg acagcttgga caaggcgctg ctgcacgcga aagagatgat 85501 cgatgatggt gcccatatca ttgatattgg aggggaatcg acaaggcctg gcgctgagtg 85561 cgtatctgag gatgaggaga tgtccagagt cattccggtg attgagcgga ttacgaaaga 85621 gcttggtgtt cctatttctg tagacacgta caaggcttct gtcgcagatg aagcagtgaa 85681 agccggtgca tccattatca atgatatttg gggagccaaa catgatccga agatggcttc 85741 cgttgcagct gaacataatg ttccaattgt actcatgcat aaccgccctg aaagaaacta 85801 caatgactta ttgccggata tgctgtcgga cttaatggag agtgtaaaaa ttgctgttga 85861 ggccggagta gacgagaaga acattattct tgatcctggt atcggtttcg cgaaaaccta 85921 tcacgataac ttggcagtga tgaacaaact agagattttc agcggattgg gatatccggt 85981 tcttctggca acctcccgaa aaagattcat cggacgtgtt ctggatcttc cgcctgagga 86041 gcgggctgag ggcacaggcg cgactgtgtg tctcggcatt caaaaaggct gtgacattgt 86101 cagggtccat gatgtaaagc aaattgccag aatggcgaaa atgatggacg cgatgctgaa 86161 taagggaggg gtgcaccatg gataaagttt atgtagaagg tatggagttt tacggatatc 86221 acggtgtgtt cacagaagaa aacaaacttg gccagcggtt taaagtcgat ttaaccgctg 86281 agctggattt aagcaaagct ggacagacag acgaccttga gcaaacgatc aactatgctg 86341 agctctatca cgtatgtaaa gatatcgtgg aaggggagcc tgtgaaattg gtggaaacgc 86401 tggcggaacg tattgctggc actgttctcg gaaaatttca gcctgttcag caatgtacgg 86461 tgaaagtgat taagccagac ccgccaattc ccggacacta taaatcagta gcaattgaaa 86521 ttacgagaaa aaagtcatga acaacatagc ttatattgca cttggatcta atattggaga 86581 tagagaaacg tatttaaggc aagcagtggc tttactgcat cagcatgctg cggtgacagt 86641 cactaaagtg tcgtctattt acgaaactga cccggtcgga tacgaagatc aagctcaatt 86701 tttgaatatg gctgttgaaa tcaagacatc attgaaccct tttgaactcc ttgaactgac 86761 gcagcagata gaaaatgaat taggcagaac aagggaagta agatgggggc cgcggacggc 86821 agaccttgac attttgttat ttaatcgtga aaatattgaa acagagcaac taattgttcc 86881 gcatccgaga atgtatgagc gtttgtttgt ccttgcgccg cttgcggaaa tttgccagca 86941 ggttgaaaaa gaggctacaa gcgccgaaac agaccaagaa ggtgtaagag tatggaagca 87001 gaaatctggg gtagacgaat tcgtgcattc agaaagctga aaggttatac tcaagaagga 87061 tttgcaaaag cattaggtat atcagtttct attctcggcg aaattgaacg cggaaaccga 87121 ttgccgtctg ctgccatcat tcaagatgca gcagatgttt taaatataag tgcggacgaa 87181 ttggcgccgc cagaaaaata gaacaaatga aaggaggaga aaaattgttc aaaatcggag 87241 atattcaatt gaaaaaccgg gttgtgctcg cacctatggc tggtgtctgc aactctgcgt 87301 tcagattgac tgtaaaggaa ttcggagccg gattggtatg cgctgaaatg gtcagtgaca 87361 aagcgatcct ttacaacaat gcaagaacaa tgggtatgct ttatattgat gaacgtgaga 87421 aaccactgag ccttcaaatt ttcggaggaa aaaaggaaac ccttgtggaa gcggcgaagt 87481 ttgtagacca aaacacaact gctgatatca ttgatattaa catgggatgt cccgtgccga 87541 agattacaaa atgcgatgcg ggagccaaat ggcttctcga tcctgataag atttacgaaa 87601 tggtttctgc agtagtggat gctgttaata agccagttac agtgaaaatg agaatgggct 87661 gggatgaaga ccacattttc gcagtgaaaa atgcacaggc tgtagaacgt gcgggcggta 87721 aagcagtggc gcttcacggc cgtacgagag tgcagatgta cgaaggaacg gcaaactggg 87781 atatcatcaa agaagtaaaa caatcagtat cgattccggt tatcggaaac ggcgatgtta 87841 agacaccgca ggatgctaag cgtatgctcg atgagacagg agtagacggg gtcatgatcg 87901 gacgcgctgc attgggtaac ccgtggatga tttaccgtac ggttcagtat cttgaaacag 87961 gtaaattaaa agaagagccg caagtacgcg aaaaaatggc cgtatgcaaa ctgcatcttg 88021 accgcctgat tgacttaaaa ggtgaaaacg tagcggtaag agaaatgaga aagcacgctg 88081 catggtatct gaaaggcgtg aaaggcaatg cgaacgttcg taatgaaatc aatcattgcg 88141 agacgagaga agagtttgta cagcttttag atgcatttac ggttgaagtt gaggcaaaag 88201 agcttcaaaa tgcaaaagta ggataatact cacctctatt tgctgctcac tgctagtttt 88261 acgctggcag tttttctgct tttttcatga aacaatatct gtaatggagt gataacaatg 88321 agtcaagaag agcataacca tgaagaattg aatgatcagc tgcaagtcag acgcgataaa 88381 atgaatcagc tgagagataa cggcatcgat ccattcggcg cacgttttga aagaactcat 88441 cagtctcaag aagttatttc ggcatatcaa gatctaacca aagaagagtt agaagaaaaa 88501 gcgattgaag ttacaatcgc aggccgcatg atgacaaaac gcggcaaagg aaaagccggc 88561 tttgcccatc ttcaggattt agaaggccaa atccaaatct acgtaagaaa agacagtgtc 88621 ggtgacgacc aatatgaaat cttcaagtct tctgacctcg gtgatcttat cggcgtaacc 88681 ggaaaagtct tcaaaacaaa tgtaggcgaa ttgtctgtta aagcaacttc ctttgaattg 88741 ctgacaaaag cgcttcgtcc gcttcctgac aaataccatg gtttaaaaga cgttgagcag 88801 cgctaccgtc agcgctatct ggatcttatc gtaaacccag acagcaaaca tacgttcatt 88861 acacgaagca agatcattca agctatgaga aggtaccttg atgatcatgg atacttagaa 88921 gtagaaacac ctacaatgca cagcattcct gggggagctt ctgcacgtcc gtttatcact 88981 caccacaacg cgttagacat tccactctat atgcgtattg ctatcgaact gcacctaaaa 89041 cgtctaattg tcggcggttt agaaaaagta tatgaaatcg gccgtgtttt ccgtaacgaa 89101 ggtgtctcta cacgccataa ccctgaattt acaatgattg agttatatga agcatatgcg 89161 gactataaag atatcatgag cttaactgaa aaccttgtcg ctcatatcgc ccaagaagtg 89221 cttggcacaa ctacgattca atacggggaa gagcaaatcg accttaaacc ggagtggaaa 89281 agaatccata tggttgacgc agtcaaagaa gcgaccggcg ttgatttctg ggaagaggtt 89341 actgttgagc aggcgcgtga atatgcaaaa gaacatgaag tagaaattaa agactctatg 89401 acagtaggcc atatcatcaa cgaattcttc gaacaaaaaa ttgaagaaac gcttattcag 89461 ccaacgttta tttacgggca tcctgtagaa atttctcctc ttgctaagaa aaaccctgag 89521 gacccgcgtt ttacagaccg ttttgagctg tttatcgttg gccgtgaaca tgccaacgcg 89581 tttacagagc tgaatgatcc tattgatcaa agagaacgct ttgaagcgca attaaaagag 89641 cgtgaagccg gtaatgatga agctcattta atggatgaag actttgttga agctctggaa 89701 tacggtatgc cgccaacagg aggtttaggc atcggtatcg accgtctggt tatgctgctg 89761 acgaatgccc cttctattcg cgatgtgctg ttattcccgc aaatgagaca acgctaataa 89821 aaaagagcgg tatcctccat agggaaagga tgccgctctt tttaaatccc ttagtatttc 89881 ttcaaaaaaa ctattgcact attatttact aggtggtata ttattattcg ttgccgctaa 89941 acaaggcgat aacgaaaaaa agaacttcaa aaaaagttat tgacttcact gagtcaacga 90001 gttataataa taaagtcgct tgaacgaagt gaacaaaatg atctttgaaa actaaacaag 90061 acaaaacgta cctgttaatt cagtttttaa aaatcgcaca gcgatgtgcg tagtcagtca 90121 aactacttta tcggagagtt tgatcctggc tcaggacgaa cgctggcggc gtgcctaata 90181 catgcaagtc gagcggacag atgggagctt gctccctgat gttagcggcg gacgggtgag 90241 taacacgtgg gtaacctgcc tgtaagactg ggataactcc gggaaaccgg ggctaatacc 90301 ggatggttgt ttgaaccgca tggttcaaac ataaaaggtg gcttcggcta ccacttgcag 90361 atggacccgc ggcgcattag ctagttggtg aggtaatggc tcaccaaggc aacgatgcgt 90421 agccgacctg agagggtgat cggccacact gggactgaga cacggcccag actcctacgg 90481 gaggcagcag tagggaatct tccgcaatgg acgaaagtct gacggagcaa cgccgcgtga 90541 gtgatgaagg ttttcggatc gtaaagctct gttgttaggg aagaacaagt gccgttcgaa 90601 tagggcggta ccttgacggt acctaaccag aaagccacgg ctaactacgt gccagcagcc 90661 gcggtaatac gtaggtggca agcgttgtcc ggaattattg ggcgtaaagg gctcgcaggc 90721 ggtttcttaa gtctgatgtg aaagcccccg gctcaaccgg ggagggtcat tggaaactgg 90781 ggaacttgag tgcagaagag gagagtggaa ttccacgtgt agcggtgaaa tgcgtagaga 90841 tgtggaggaa caccagtggc gaaggcgact ctctggtctg taactgacgc tgaggagcga 90901 aagcgtgggg agcgaacagg attagatacc ctggtagtcc acgccgtaaa cgatgagtgc 90961 taagtgttag ggggtttccg ccccttagtg ctgcagctaa cgcattaagc actccgcctg 91021 gggagtacgg tcgcaagact gaaactcaaa ggaattgacg ggggcccgca caagcggtgg 91081 agcatgtggt ttaattcgaa gcaacgcgaa gaaccttacc aggtcttgac atcctctgac 91141 aatcctagag ataggacgtc cccttcgggg gcagagtgac aggtggtgca tggttgtcgt 91201 cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct tgatcttagt 91261 tgccagcatt cagttgggca ctctaaggtg actgccggtg acaaaccgga ggaaggtggg 91321 gatgacgtca aatcatcatg ccccttatga cctgggctac acacgtgcta caatggacag 91381 aacaaagggc agcgaaaccg cgaggttaag ccaatcccac aaatctgttc tcagttcgga 91441 tcgcagtctg caactcgact gcgtgaagct ggaatcgcta gtaatcgcgg atcagcatgc 91501 cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccacga gagtttgtaa 91561 cacccgaagt cggtgaggta accttttagg agccagccgc cgaaggtggg acagatgatt 91621 ggggtgaagt cgtaacaagg tagccgtatc ggaaggtgcg gctggatcac ctcctttcta 91681 aggatatttt acggaatata agaccttggg tcttataaac agaacgttcc ctgtcttgtt 91741 tagttttgaa ggatcattcc ttcgaaacgt gttctttgaa aactagataa cagtagacat 91801 cacattcaag taatacaaga tatcacatag tgattctttt taacggttaa gttagaaagg 91861 gcgcacggtg gatgccttgg cactaggagc cgatgaagga cgggacgaac accgatatgc 91921 ttcggggagc tgtaagcaag ctttgatccg gagatttccg aatggggaaa cccaccactc 91981 gtaatggagt ggtatccata tctgaattca taggatatga gaaggcagac ccggggaact 92041 gaaacatcta agtacccgga ggaagagaaa gcaaatgcga ttccctgagt agcggcgagc 92101 gaaacgggat tagcccaaac caagaggctt gcctcttggg gttgtaggac actctgtacg 92161 gagttacaaa ggaacgaggt agatgaagag gtctggaaag gcccgccata ggaggtaaca 92221 gccctgtagt caaaacttcg ttctctcctg agtggatcct gagtacggcg gaacacgtga 92281 aattccgtcg gaatccggga ggaccatctc ccaaggctaa atactcccta gtgaccgata 92341 gtgaaccagt accgtgaggg aaaggtgaaa agcaccccgg aaggggagtg aaagagatcc 92401 tgaaaccgtg tgcctacaag tagtcagagc ccgttaacgg gtgatggcgt gccttttgta 92461 gaatgaaccg gcgagttacg atcccgtgca aggttaagca gaagatgcgg agccgcagcg 92521 aaagcgagtc tgaatagggc gcatgagtac gtggtcgtag acccgaaacc aggtgatcta 92581 cccatgtcca gggtgaagtt caggtaacac tgaatggagg cccgaaccca cgcacgttga 92641 aaagtgcggg gatgaggtgt gggtaggggt gaaatgccaa tcgaacctgg agatagctgg 92701 ttctctccga aatagcttta gggctagcct caaggtaaga gtcttggagg tagagcactg 92761 attggactag gggcccctac cgggttaccg aattcagtca aactccgaat gccaatgact 92821 tatccttggg agtcagactg cgagtgataa gatccgtagt cgaaagggaa acagcccaga 92881 ccgccagcta aggtcccaaa gtatacgtta agtggaaaag gatgtggagt tgcttagaca 92941 accaggatgt tggcttagaa gcagccacca tttaaagagt gcgtaatagc tcactggtcg 93001 agtgactctg cgccgaaaat gtaccggggc taaacgtatc accgaagctg cggactgttc 93061 ttcgaacagt ggtaggagag cgttctaagg gctgtgaagc cagaccggaa ggactggtgg 93121 agcgcttaga agtgagaatg ccggtatgag tagcgaaaga ggggtgagaa tcccctccac 93181 cgaatgccta aggtttcctg aggaaggctc gtccgctcag ggttagtcgg gacctaagcc 93241 gaggccgaaa ggcgtaggcg atggacaaca ggttgatatt cctgtaccac ctcctcacca 93301 tttgagcaat ggggggacgc aggaggatag ggtaagcgcg gtattggata tccgcgtcca 93361 agcagttagg ctgggaaata ggcaaatccg tttcccataa ggctgagctg tgatggcgag 93421 cgaaatatag tagcgaagtt cctgattcca cactgccaag aaaagcctct agcgaggtga 93481 gaggtgcccg taccgcaaac cgacacaggt aggcgaggag agaatcctaa ggtgatcgag 93541 agaactctcg ttaaggaact cggcaaaatg accccgtaac ttcgggagaa ggggtgctct 93601 gttagggtgc aagcccgaga gagccgcagt gaataggccc aggcgactgt ttagcaaaaa 93661 cacaggtctc tgcgaagccg taaggcgaag tataggggct gacgcctgcc cggtgctgga 93721 aggttaagag gagcgcttag cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg 93781 ccgtaactat aacggtccta aggtagcgaa attccttgtc gggtaagttc cgacccgcac 93841 gaaaggcgca acgatctggg cactgtctca acgagagact cggtgaaatt atagtacctg 93901 tgaagatgca ggttacccgc gacaggacgg aaagaccccg tggagcttta ctgcagcctg 93961 atattgaatg ttggtacagc ttgtacagga taggtaggag ccttggaaac cggagcgcca 94021 gcttcggtgg aggcatcggt gggatactac cctggctgta ttgaccttct aacccgccgc 94081 ccttatcggg cggggagaca gtgtcaggtg ggcagtttga ctggggcggt cgcctcctaa 94141 aaggtaacgg aggcgcccaa aggttccctc agaatggttg gaaatcattc gcagagtgta 94201 aaggcacaag ggagcttgac tgcgagacct acaagtcgag cagggacgaa agtcgggctt 94261 agtgatccgg tggttccgca tggaagggcc atcgctcaac ggataaaagc taccccgggg 94321 ataacaggct tatctccccc aagagtccac atcgacgggg aggtttggca cctcgatgtc 94381 ggctcatcgc atcctggggc tgtagtcggt cccaagggtt gggctgttcg cccattaaag 94441 cggtacgcga gctgggttca gaacgtcgtg agacagttcg gtccctatcc gtcgcgggcg 94501 caggaaattt gagaggagct gtccttagta cgagaggacc gggatggacg caccgctggt 94561 gtaccagttg ttctgccaag ggcatcgctg ggtagctatg tgcggacggg ataagtgctg 94621 aaagcatcta agcatgaagc ccccctcaag atgagatttc ccattccgca aggaagtaag 94681 atccctgaaa gatgatcagg ttgataggtc tgaggtggaa gtgtggcgac acatggagct 94741 gacagatact aatcgatcga ggacttaacc atatttttga atgatgtcac atctgttatc 94801 tagttttgag agaacactct caatttgttt ggtggcgata gcgaagaggt cacacccgtt 94861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 94921 gtgagagtag gacgccgcca agcaattgca cgttagtgca attatggagg attagctcag 94981 ctgggagagc atctgcctta caagcagagg gtcggcggtt cgagcccgtc atcctccacc 95041 attatgccgg tgtagctcaa ttggtagagc aactgacttg taatcagtag gttgggggtt 95101 caagtcctct tgccggcacc acttttatat gatataatac tcaagtctct tgtagaagag 95161 ccattagctc agttggtaga gcatctgact tttaatcaga gggtcgaagg ttcgagtcct 95221 tcatggctca ccattttacg cgggtgtggc ggaattggca gacgcgctag acttaggatc 95281 tagtgtcttt atgacgtggg ggttcaagtc ccttcacccg cattatatag gataacagtt 95341 agaaaaactg gacatcctgt ctgcggaagt agttcagtgg tagaacacca ccttgccaag 95401 gtgggggtcg cgggttcgaa tcccgtcttc cgctccaact ataccatcca cgccggggtg 95461 gtggaattgg cagacacaca ggacttaaaa tcctgcggta ggtgactacc gtgccggttc 95521 aagtccggcc ctcggcatta tgttttgcgc ccgtagctca attggataga gcgtttgact 95581 acggatcaaa aggttagggg ttcgactcct ctcgggcgcg ccatatcttt taatagaata 95641 gataggaaat cgggaagtag ctcagcttgg tagagcacat ggtttgggac catggggtcg 95701 caggttcgaa tcctgtcttc ccgaccattt ttttatgggg ccttagctca gctgggagag 95761 cgcctgcttt gcacgcagga ggtcagcggt tcgatcccgc taggctccac caaaagtttt 95821 taaaaaagtt gttgactttg aagaagtgac gttgtatact aataaagttg ctttaacaaa 95881 gcggacaaac aaaatgatct ttgaaaacta aacaagacaa aacgtacctg ttaattcagt 95941 ttttaaaaat cgcacagcga tgtgcgtagt cagtcaaact actttatcgg agagtttgat 96001 cctggctcag gacgaacgct ggcggcgtgc ctaatacatg caagtcgagc ggacagatgg 96061 gagcttgctc cctgatgtta gcggcggacg ggtgagtaac acgtgggtaa cctgcctgta 96121 agactgggat aactccggga aaccggggct aataccggat ggttgtttga accgcatggt 96181 tcaaacataa aaggtggctt cggctaccac ttacagatgg acccgcggcg cattagctag 96241 ttggtgaggt aacggctcac caaggcaacg atgcgtagcc gacctgagag ggtgatcggc 96301 cacactggga ctgagacacg gcccagactc ctacgggagg cagcagtagg gaatcttccg 96361 caatggacga aagtctgacg gagcaacgcc gcgtgagtga tgaaggtttt cggatcgtaa 96421 agctctgttg ttagggaaga acaagtaccg ttcgaatagg gcggtacctt gacggtacct 96481 aaccagaaag ccacggctaa ctacgtgcca gcagccgcgg taatacgtag gtggcaagcg 96541 ttgtccggaa ttattgggcg taaagggctc gcaggcggtt tcttaagtct gatgtgaaag 96601 cccccggctc aaccggggag ggtcattgga aactggggaa cttgagtgca gaagaggaga 96661 gtggaattcc acgtgtagcg gtgaaatgcg tagagatgtg gaggaacacc agtggcgaag 96721 gcgactctct ggtctgtaac tgacgctgag gagcgaaagc gtggggagcg aacaggatta 96781 gataccctgg tagtccacgc cgtaaacgat gagtgctaag tgttaggggg tttccgcccc 96841 ttagtgctgc agctaacgca ttaagcactc cgcctgggga gtacggtcgc aagactgaaa 96901 ctcaaaggaa ttgacggggg cccgcacaag cggtggagca tgtggtttaa ttcgaagcaa 96961 cgcgaagaac cttaccaggt cttgacatcc tctgacaatc ctagagatag gacgtcccct 97021 tcgggggcag agtgacaggt ggtgcatggt tgtcgtcagc tcgtgtcgtg agatgttggg 97081 ttaagtcccg caacgagcgc aacccttgat cttagttgcc agcattcagt tgggcactct 97141 aaggtgactg ccggtgacaa accggaggaa ggtggggatg acgtcaaatc atcatgcccc 97201 ttatgacctg ggctacacac gtgctacaat ggacagaaca aagggcagcg aaaccgcgag 97261 gttaagccaa tcccacaaat ctgttctcag ttcggatcgc agtctgcaac tcgactgcgt 97321 gaagctggaa tcgctagtaa tcgcggatca gcatgccgcg gtgaatacgt tcccgggcct 97381 tgtacacacc gcccgtcaca ccacgagagt ttgtaacacc cgaagtcggt gaggtaacct 97441 tttaggagcc agccgccgaa ggtgggacag atgattgggg tgaagtcgta acaaggtagc 97501 cgtatcggaa ggtgcggctg gatcacctcc tttctaagga tattttacgg aatataagac 97561 cttgggtctt ataaacagaa cgttccctgt cttgtttagt tttgaaggat cattccttcg 97621 aaacgtgttc tttgaaaact agataacagt agacatcaca ttcaagtaat acaagatatc 97681 acatagtgat tctttttaac ggttaagtta gaaagggcgc acggtggatg ccttggcact 97741 aggagccgat gaaggacggg acgaacaccg atatgcttcg gggagctgta agcaagcttt 97801 gatccggaga tttccgaatg gggaaaccca ccactcgtaa tggagtggta tccatatctg 97861 aattcatagg atatgagaag gcagacccgg ggaactgaaa catctaagta cccggaggaa 97921 gagaaagcaa atgcgattcc ctgagtagcg gcgagcgaaa cgggatcagc ccaaaccaag 97981 aggcttgcct cttggggttg taggacactc tgtacggagt tacaaaggaa cgaggtagat 98041 gaagaggtct ggaaaggccc gccataggag gtaacagccc tgtagtcaaa acttcgttct 98101 ctcctgagtg gatcctgagt acggcggaac acgtgaaatt ccgtcggaat ccgggaggac 98161 catctcccaa ggctaaatac tccctagtga ccgatagtga accagtaccg tgagggaaag 98221 gtgaaaagca ccccggaagg ggagtgaaag agatcctgaa accgtgtgcc tacaagtagt 98281 cagagcccgt taacgggtga tggcgtgcct tttgtagaat gaaccggcga gttacgatcc 98341 cgtgcaaggt taagcagaag atgcggagcc gcagcgaaag cgagtctgaa tagggcgcat 98401 gagtacgtgg tcgtagaccc gaaaccaggt gatctaccca tgtccagggt gaagttcagg 98461 taacactgaa tggaggcccg aacccacgca cgttgaaaag tgcggggatg aggtgtgggt 98521 aggggtgaaa tgccaatcga acctggagat agctggttct ctccgaaata gctttagggc 98581 tagcctcaag gtaagagtct tggaggtaga gcactgattg gactaggggc ccctaccggg 98641 ttaccgaatt cagtcaaact ccgaatgcca atgacttatc cttgggagtc agactgcgag 98701 tgataagatc cgtagtcgaa agggaaacag cccagaccgc cagctaaggt cccaaagtat 98761 acgttaagtg gaaaaggatg tggagttgct tagacaacca ggatgttggc ttagaagcag 98821 ccaccattta aagagtgcgt aatagctcac tggtcgagtg actctgcgcc gaaaatgtac 98881 cggggctaaa cgtatcaccg aagctgcgga ctgttcttcg aacagtggta ggagagcgtt 98941 ctaagggctg tgaagccaga ccggaaggac tggtggagcg cttagaagtg agaatgccgg 99001 tatgagtagc gaaagagggg tgagaatccc ctccaccgaa tgcctaaggt ttcctgagga 99061 aggctcgtcc gctcagggtt agtcgggacc taagccgagg ccgaaaggcg taggcgatgg 99121 acaacaggtt gatattcctg taccacctcc tcaccatttg agcaatgggg ggacgcagga 99181 ggatagggta agcgcggtat tggatatccg cgtccaagca gttaggctgg gaaataggca 99241 aatccgtttc ccataaggct gagctgtgat ggcgagcgaa atatagtagc gaagttcctg 99301 attccacact gccaagaaaa gcctctagcg aggtgagagg tgcccgtacc gcaaaccgac 99361 acaggtaggc gaggagagaa tcctaaggtg atcgagagaa ctctcgttaa ggaactcggc 99421 aaaatgaccc cgtaacttcg ggagaagggg tgctctgtta gggtgcaagc ccgagagagc 99481 cgcagtgaat aggcccaggc gactgtttag caaaaacaca ggtctctgcg aagccgtaag 99541 gcgaagtata ggggctgacg cctgcccggt gctggaaggt taagaggagc gcttagcgta 99601 agcgaaggtg cgaattgaag ccccagtaaa cggcggccgt aactataacg gtcctaaggt 99661 agcgaaattc cttgtcgggt aagttccgac ccgcacgaaa ggcgcaacga tctgggcact 99721 gtctcaacga gagactcggt gaaattatag tacctgtgaa gatgcaggtt acccgcgaca 99781 ggacggaaag accccgtgga gctttactgc agcctgatat tgaatgttgg tacagcttgt 99841 acaggatagg taggagcctt ggaaaccgga gcgccagctt tggtggaggc atcggtggga 99901 tactaccctg gctgtattga ccttctaacc cgccgccctt atcgggcggg gagacagtgt 99961 caggtgggca gtttgactgg ggcggtcgcc tcctaaaagg taacggaggc gcccaaaggt 100021 tccctcagaa tggttggaaa tcattcgcag agtgtaaagg cacaagggag cttgactgcg 100081 agacctacaa gtcgagcagg gacgaaagtc gggcttagtg atccggtggt tccgcatgga 100141 agggccatcg ctcaacggat aaaagctacc ccggggataa caggcttatc tcccccaaga 100201 gtccacatcg acggggaggt ttggcacctc gatgtcggct catcgcatcc tggggctgta 100261 gtcggtccca agggttgggc tgttcgccca ttaaagcggt acgcgagctg ggttcagaac 100321 gtcgtgagac agttcggtcc ctatccgtcg cgggcgcagg aaatttgaga ggagctgtcc 100381 ttagtacgag aggaccggga tggacgcacc gctggtgtac cagttgttct gccaagggca 100441 tcgctgggta gctatgtgcg gacgggataa gtgctgaaag catctaagca tgaagccccc 100501 ctcaagatga gatttcccat tccgcaagga agtaagatcc ctgaaagatg atcaggttga 100561 taggtctgag gtggaagtgt ggcgacacat ggagctgaca gatactaatc gatcgaggac 100621 ttaaccatat ttttgaatga tgtcacatct gttatctagt tttgagagaa cactctcaat 100681 ttgtttggtg gcgatagcga agaggtcaca cccgttccca taccgaacac ggaagttaag 100741 ctcttcagcg ccgatggtag tcgggggttt ccccctgtga gagtaggacg ccgccaagca 100801 agcttaaacc cagctcaatg agctgggttt tttgtatttt ggtttattgg tatcataaaa 100861 ttccacttaa ctgtataata taataacttt ataccgaatt ttaaatcagc aatcaggttt 100921 tgtggaccgg gaaaatggaa ataatgaagg atagagcgag aaagttgaaa attctcgaga 100981 aacggcttat agtaagatta aagtcaaata tagtcaaagt cagtaaagga gggggttgag 101041 tgggacataa tatttctgac atcattgaac aatatttaaa acgagtgtta gatcaaaatg 101101 gcaaggaaat tttagagatt aaacgaagtg aaattgcaga taaatttcaa tgcgttcctt 101161 cccaaataaa ttatgtcatc aacaccagat ttacaagcga aagaggatat attgttgaga 101221 gcaaacgcgg gggcggcggt tacatcagaa tcattaaaat taaaatgaac aatgaagttg 101281 tcctgatcaa taatataatt tctcaaatta atacccattt gtctcaagca gcctctgatg 101341 acattatttt aaggctatta gaagacaagg taatttcaga aagagaagca aaaatgatgg 101401 tcagcgtaat ggaccgctca gttttacaca ttgacttacc tgaacgtgat gaattaagag 101461 cgagaatgat gaaggcaatg ctgacttctt taaaattaaa ataagcgggt gaaaagattg 101521 atttgtcaag agtgccacga gagaccagcc acttttcact ttacaaaggt tgttaacgga 101581 gaaaaaatag aagttcatat ttgtgaacaa tgtgccaaag aaaatagtga ttcatatggt 101641 ataagtgcaa atcagggttt ctctattcat aatttacttt cgggtttact gaacatggat 101701 tcttcatttc aaaatgcagg aactcaaatg ttcagtcact cggagcaaat atctgcttgt 101761 ccgaaatgcg gaatgacttt tcagcaattc agaaaaattg gccgttttgg atgttctgaa 101821 tgttacaaaa catttcatag caacattaca ccaatcctac gtaaagtgca cagcggaaac 101881 actgtgcatg caggtaagat accgaaacga ataggcggca atcttcatgt cagacggcag 101941 attgatatgc taaaaaagga attagaatcc ttaatccatc aagaagaatt tgaaaatgca 102001 gctcatgtaa gagatcaaat tcgtttatta gaacaatcac tcaaaagtac agatagtgag 102061 gaggaacagg agtaatgtcg ctaaagcatt ttattcagga cgcactaagc agttggatga 102121 agcagaaagg acctgaaagt gacattgtac tcagcagccg catacgttta gcaagaaact 102181 ttgagcatat tcggttccct acgcggtatt ccaatgaaga agcctcatcc atcatacagc 102241 aatttgaaga tcagttttca gagcaagaaa ttcccggaat cggcaaattt gttttgatta 102301 gaatgaatga tgcacagcct ttagaaaagc gtgtacttgt tgaaaaacat ctaatcagcc 102361 cgaatttgac agagtctcct tttggcggct gtttgctttc tgaaaatgag gaagtaagcg 102421 tcatgctaaa tgaagaggac catattagaa ttcagtgtct tttccctgga tttcagcttt 102481 tagaagcaat gaaagccgca aaccaggtcg acgactggat tgaagaaaaa gttgattatg 102541 cattcaatga gcaaagagga tacttaacca gctgtcctac aaacgtaggt actggtttaa 102601 gggcttcggt catgatgcat ctgccggcgc tggttttaac taggcaaata aatcgaatta 102661 taccggcaat taatcaatta ggcttagttg ttagaggaat ttatggggaa ggcagcgaag 102721 cagtagggaa tatctttcaa atttcaaatc agatcacgct tggtaagtca gagcaggata 102781 ttgtagagga tcttaacagt gttgctgctc agttgattga acaagaacga tctgcccgag 102841 aagcgattta tcaaacttct aaaatcgaac ttgaggatcg ggtatatcgg tcatatgggg 102901 tcttgtctaa ttgccggatg atagaatcga aagaaactgc aaagtgcctt tcagatgttc 102961 ggttaggcat agacttaggc ataataaaag gactttcaag caacatactt aacgaactta 103021 tgattttgac gcagccaggg tttttacagc aatactcggg aggcgctttg cgaccgaacg 103081 aaagggacat tcgaagagcg gctctcatca gagaacggct tcacttagaa atgaatggga 103141 aaagacagga ggatgaatcg atatgatgtt tggaagattt acagaacgag ctcaaaaagt 103201 actggcgcta gcacaggaag aagcacttcg gttaggtcat aataacattg gcactgagca 103261 tattttatta ggactggtaa gagaaggaga gggcattgct gctaaagctc ttcaagcgct 103321 tggactcggt tcagaaaaaa ttcagaaaga agtagaaagt ttgatcgggc gcgggcagga 103381 aatgtctcaa acgattcatt atactcctag agctaaaaaa gtcattgagc tttcaatgga 103441 tgaggcaaga aaactcggtc attcttatgt gggaacagaa catattcttc ttggtctgat 103501 tcgtgaagga gaaggtgttg ctgcgagagt tctgaataat ctcggtgtca gcttaaataa 103561 agcaagacag caggtgctcc agcttctagg aagtaatgaa acaggatcat cagcggcagg 103621 aacaaacagc aatgcgaata cgcctacgct tgacagcttg gcaagagact taactgctat 103681 tgcgaaggaa gacagccttg accctgtaat cggcagaagc aaggagatcc agcgtgtcat 103741 tgaagtgtta agccgcagaa cgaaaaacaa ccctgttctc attggggaac caggtgtagg 103801 taaaacggct atcgcagaag gtttggcaca gcaaattatc aataatgaag tacccgaaat 103861 tttgcgtgat aaacgtgtga tgacattaga catgggaaca gttgttgccg gcacaaaata 103921 ccgcggagaa tttgaggatc gcctgaagaa ggtcatggat gaaattcgcc aggcaggaaa 103981 tatcattcta ttcatcgatg agctccatac attaatcggg gcaggcggag cagaaggtgc 104041 tattgatgca tctaatattt taaaaccttc acttgctcgt ggcgaactcc aatgtattgg 104101 tgcaacgact cttgatgagt accgtaaata tattgaaaaa gatgcagcac tggaacgccg 104161 ttttcagccg attcaggttg atcagccatc tgtagatgaa agtattcaaa ttttacaagg 104221 tctgcgtgac agatacgaag cccaccaccg cgtttctatc actgatgatg ccattgaagc 104281 tgcggttaag ctttctgaca gatatatttc tgaccgcttc cttccggata aagcaattga 104341 cttgatcgat gaagcgggtt caaaggtgag actgcgctca tttacaacgc ctcctaactt 104401 aaaagagctt gagcagaagc ttgatgaggt tcgtaaagag aaggatgcgg cagtgcaaag 104461 ccaagagttt gaaaaagctg cttccttgcg tgatactgaa caacgcctgc gcgagcaagt 104521 agaggatacg aagaaatcat ggaaagagaa gcaagggcag gaaaactcag aggttactgt 104581 ggatgatatt gcgatggttg tatccagctg gaccggtgtg cctgtatcta aaatcgccca 104641 aactgaaact gataagcttc tcaatatgga aaacattctt cactcccgtg tcatcggcca 104701 ggatgaagca gttgtagcgg ttgcaaaagc cgtcagacgt gcaagagcag gattgaaaga 104761 tcctaaacgc ccaatcggct cattcatttt cttaggccct acaggtgtag gtaaaacaga 104821 acttgcacga gcacttgctg aatccatttt tggcgatgaa gaatccatga tcagaattga 104881 tatgtctgaa tacatggaaa aacattcaac ttcaagactt gttggttcac ctccgggtta 104941 tgtgggatat gatgaaggcg gtcaattgac agagaaagtc agaagaaaac cttactctgt 105001 cgtgcttctt gatgagatcg agaaagcgca ccctgatgtc ttcaatatcc ttctgcaagt 105061 tcttgaagac ggacgattga ctgattctaa aggacgcaca gtcgatttcc gcaataccat 105121 tctgatcatg acatcaaacg tcggagcaag tgagctaaaa cgcaataaat atgtcggctt 105181 taacgttcag gatgaaactc aaaatcataa agacatgaaa gataaagtga tgggtgaatt 105241 aaaacgagcg ttcagacctg agttcatcaa ccgtattgat gaaatcattg tcttccattc 105301 acttgagaaa aaacatctca ctgagattgt gtcattaatg tctgatcaat taacgaaacg 105361 cctgaaagaa caagatcttt ctatcgaatt gacagatgct gcaaaagcga aagtcgcgga 105421 agagggcgtt gacctggaat acggtgcccg tccgttaaga agagcgatcc aaaaacatgt 105481 cgaggatcgt ttatctgaag aactcctcag aggaaatatt cataaaggac agcatattgt 105541 tcttgatgta gaagatggcg aatttgtcgt aaaaacgact gctaaaacga attaatatag 105601 aagacggaaa tgaggcatac agcatgtaag tgtatgcctc actttcatat caagaaatag 105661 aacaagggag aggtcttaca ctatatatgg ctaaaacaaa atcgaagttc atctgccaat 105721 cctgcggcta cgagtctcca aaatggatgg ggaaatgtcc gggctgtggt gcttggaata 105781 caatggtgga agaaatgatt aaaaaagcac cggccaatcg gagagcggct ttttctcatt 105841 ctgttcaaac tgtacagaaa ccttcaccta ttacatcaat cgaaacatca gaagaacccc 105901 gcgtcaaaac ccagcttggc gagtttaaca gagtactcgg cggaggtgtc gttaaaggct 105961 ccctcgtttt aattggcggt gatcctggta tcggaaagtc aacgctatta ctgcaggttt 106021 ccgctcaatt atcaggctca tcaaacagtg tcctgtatat ttcgggagaa gaatctgtaa 106081 agcaaacgaa gctgcgagca gaccgtctcg gcattaataa tccgtcactg catgttttat 106141 ctgaaaccga tatggagtat atttcgtctg ctatacaaga gatgaatcca tcgtttgtcg 106201 ttgttgactc tattcaaacg gtttaccaaa gcgatattac atctgctcca ggcagtgtgt 106261 cacaggtcag agaatgtacc gctgagctga tgaaaattgc aaaaacaaaa ggtattccga 106321 tttttatcgt agggcacgtg acgaaagaag ggtctattgc aggtccgaga ctgttggagc 106381 atatggttga cactgtttta tattttgaag gagaacgcca ccatactttc cgtattttgc 106441 gggctgtaaa aaaccgtttc ggatctacaa acgaaatggg cattttcgaa atgcgggaag 106501 aggggctcac tgaggttttg aatccttcgg aaattttctt agaagaacgc tctgctggtt 106561 ccgcaggctc gagtatcact gcctctatgg agggcactag accgattctc gttgaaattc 106621 aggcactcat ctcgccaaca agttttggca acccaaggcg tatggcaacg ggaatagacc 106681 ataacagggt ttctctgtta atggctgtgt tagaaaaaag agttggactg ctgctgcaaa 106741 atcaggatgc ttatttgaaa gtggctggcg gcgttaagct tgatgaaccg gcaattgatc 106801 ttgcgattgt gattagtatt gcatcaagct ttagagacac acctccaaat cctgcagatt 106861 gttttattgg agaagtggga ttaaccggag aagtccggcg ggtttcaaga attgaacagc 106921 gtgtgaaaga agcggcaaag cttggtttta aacgcatgat catacccgcg gcaaatctgg 106981 atggatggac aaaaccaaaa gggattgagg ttatcggagt agcaaatgtt gcagaagcgc 107041 ttcgtacttc attaggagga taatagatgg aaaaagagaa aaaaggggcg aaacacgagt 107101 tagacctgtc atctatattg cagtttgttg ctccgggtac accgctcaga gcggggatgg 107161 aaaacgtctt gagagcaaat acaggcggtc tgattgttgt tggatataat gataaagtaa 107221 aagaagtggt ggacggcggc tttcacataa acacggcttt ttctccggcg catttatatg 107281 agctggctaa aatggatgga gcgatcattt taagtgattc tggtcaaaag atcctatacg 107341 cgaatactca gctgatgccg gatgccacaa tttcttcatc agaaacagga atgcggcaca 107401 gaactgccga aagagtagct aagcaaactg gctgtcttgt aatcgccatt tctgaaagaa 107461 gaaatgtcat aacgttatat caggaaaaca tgaagtatac actaaaagac ataggattta 107521 ttttaaccaa ggcgaaccaa gccattcaaa cacttgaaaa atataagaca atcctcgata 107581 aaacgattaa tgcactgaac gcgttagagt ttgaggaact tgttaccttc agtgatgtct 107641 tgtctgtcat gcatcgttat gaaatggtac tgagaatcaa aaacgaaatt aatatgtata 107701 tcaaagagct ggggacagaa gggcatctga tcaaactgca agtcattgaa ttgattacgg 107761 atatggaaga agaggccgct ttatttatta aggactatgt aaaagaaaag attaaagatc 107821 cgtttgttct cttgaaggag ctgcaggata tgtccagtta tgatctgctg gatgattcca 107881 ttgtgtataa gcttctcggt taccctgctt ctactaatct tgatgattat gtattgccga 107941 gaggatacag gctgttaaat aagataccgc gtcttccgat gccgattgtt gaaaatgttg 108001 tagaagcatt tggagtcctg ccaaggatta ttgaggcgag tgcagaagaa ttagatgaag 108061 tagagggaat cggtgaagta cgagcccaaa aaatcaaaaa aggattaaaa cgcctgcaag 108121 agaagcatta tttagacaga caactgtgat ttcggttaaa accttatgaa tacgggtata 108181 ttaatgttgg tttttgttta ttctgatatt cgtaggatgc ataagacttt gtgaaattaa 108241 aatgttaaaa aaggaggtgg gggtatgtta aaacgaatag ttcaggcgtt cttcattatt 108301 tttggcggcg ttgttggtat atttttgata cctgaattgt ttgtactgtt aaatatacag 108361 gacatacctt taataacaaa cgcatatacg tctgcggcaa taggagcaat tatctttttt 108421 ctcatcagta tatggggtac agaatacgtt gtgaactggg tgaagtggat agaggattca 108481 ttgttaaaag cgccggttcc agatttgtta tttggaagtc ttggcttagt ttttggactt 108541 ataattgctt atcttatcgt aaatgttatt cctttagaca atatacctta ccgcatattc 108601 agcacaataa ttcctgtatt tttggctttc ttcctcggtt atctcggctt ccaggtgggc 108661 tttaagaaaa aggatgaatt gatcagcctg ttttccattt ccgccagaat gcaaaagaaa 108721 aaaggaacag ctgatgaaga acatgaggtt caagacaaga agctgaaaat tttggacact 108781 agtgttatta ttgatgggag aatagcagat atttgtcaga ctggtttttt agagggagtt 108841 atcgtgattc cgcagtttgt ccttgaggaa ttgcagcata ttgcagactc ttcagatgtt 108901 ttaaaacgaa acagaggacg ccgcggtctt gatatcctga accgcattca gaaagaatta 108961 gacattgaag ttgaaattta cgaaggcgac tttgaagata ttcaggaggt tgacagcaag 109021 ctcgtcaaac ttgctaagct gacatccggg gtcgttgtga cgaatgattt taatttaaat 109081 aaagtgtgcg agcttcagaa ggtagcagta ttaaacatta atgaccttgc caatgcggtt 109141 aagcctgttg tgcttcctgg cgaggaaatg aatgttcagg tcattaagga cgggaaagag 109201 cataatcagg gagttgccta cttggatgac ggtacgatga ttgtcgttga agaaggacgg 109261 aattatatcg gcaagcatat tgatgtactc gtcacaagtg tgctgcagac agcagcggga 109321 cgaatgattt ttgcgaagcc taagctgttg gagaaggcgc tgtaaaggga gaagaaacaa 109381 tgagttatga tgtggtgatt cctgcagccg gacagggaaa gcggatgaag gcagggagaa 109441 ataaactgtt cattgagctg aagggagacc cggtgatcat acacacgtta agagtgtttg 109501 acagccaccg gcagtgcgat aaaatcattt tggtgattaa cgagcaggag cgggagcact 109561 ttcagcaatt gctgtccgat tacccgtttc aaacttcaat tgagcttgtt gcaggcggag 109621 atgagcgaca gcacagtgtg tataaggggc tgaaagccgt aaagcaggaa aagattgtcc 109681 ttgtacatga cggtgcccgt ccatttataa aacatgaaca aattgacgaa ctgatcgcag 109741 aggcggaaca gacaggagcg gccatccttg ctgttccggt aaaagatacg attaaacgcg 109801 ttcaagattt acaagtcagt gagacgattg aacgttcaag cttgtgggct gtccaaacgc 109861 cacaagcttt tcgtctttct ttattgatga aggctcacgc tgaggccgag cgcaagggat 109921 ttttagggac ggatgacgcc agcctcgttg aacagatgga gggcggttcg gtccgtgttg 109981 tagaaggcag ctatacaaat attaagctga cgacgccaga cgatttgacg tcagctgaag 110041 ctatcatgga atcagaaagt gggaataaac atgtttagaa ttggacaagg atttgatgtg 110101 catcaattag tggagggccg tcctctcatt attggcggaa ttgaaatccc gtacgaaaaa 110161 gggctgcttg gccattctga tgcagacgta ttgttgcata ccgtcgctga cgcctgcctg 110221 ggagctgtgg gtgaaggaga cataggcaag cattttcctg acacagatcc cgagttcaag 110281 gacgcagatt ctttcaaatt acttcagcat gtctggggaa tcgtgaaaca gaaggggtat 110341 gtccttggga acattgattg caccatcata gcgcaaaagc cgaagatgct gccgtacata 110401 gaagatatga gaaaaagaat tgctgaaggc cttgaggcag atgtttctca agtaaatgta 110461 aaagcaacaa cgacagaaaa gcttggattt acaggccggg cggaaggaat agcggctcag 110521 gcgacagtac tgatacaaaa aggctaactt gttttgatgc cgggtctatt tggtggtaga 110581 atagattcat acatttttgc ctgaggccat acatgacatg aaaggaagta tttgaaaatg 110641 ggaaacgaag tacgcgtccg ttatgcaccg agtccaaccg gacatttgca tattggaaat 110701 gccagaacgg cgctttttaa ttatttattt gcccgcaatc aaggcggtaa gtttatcatt 110761 cgagttgagg atactgataa aaagcgcaat attgagggcg gagaacaaag ccagctgaat 110821 tatctgaagt ggctaggtat tgactgggat gagagtgtgg atgtcggagg agagtacggt 110881 ccataccgtc agtcagagcg taacgatatc tataaagtgt actatgaaga gcttcttgaa 110941 aaagggcttg cttataaatg ttactgtacg gaagaagagc ttgaaaaaga gcgtgaagaa 111001 cagattgccc gcggagaaat gcctcgttat tccggaaaac acagagacct gactcaggaa 111061 gaacaggaga aatttatcgc cgaaggcaga aaaccaagta ttcgtttccg tgtgccggaa 111121 ggaaaagtca tcgccttcaa cgacatcgta aaaggcgaaa tttcttttga atcagatggc 111181 atcggcgact tcgttattgt gaaaaaggac ggaacgccta cttataactt cgcggtagct 111241 attgatgact acttaatgaa aatgacacac gtgctgcgcg gtgaggatca tatttctaac 111301 acaccgaaac agattatgat ctatcaagca ttcgggtggg atattcctca gttcggacac 111361 atgacgctga ttgtaaacga aagccgtaaa aagctcagca aacgtgatga atccattatt 111421 caattcatcg agcagtacaa agagcttggc tacctgccag aagcgctgtt caactttatc 111481 ggcttgttag gctggtcacc ggttggagaa gaagagcttt tcacaaaaga gcagtttatt 111541 gaaatttttg atgtaaatcg tttatctaaa tcaccagctt tgtttgatat gcataagcta 111601 aaatgggtta acaaccaata tgtgaagaag ctggatcttg atcaggttgt tgaactgacg 111661 cttccgcatt tgcaaaaagc cggcaaagtt ggcactgagc tttctgctga agaacaagaa 111721 tgggttcgta aactgatttc cctgtatcat gagcaattaa gctacggtgc ggaaattgtt 111781 gagctgactg atttgttctt tacggatgag atcgagtata atcaagaagc gaaagctgtt 111841 ctggaagaag aacaggttcc tgaagtgctc agcacattcg cagcgaagct tgaagagctt 111901 gaggagttca ctccggataa tatcaaagca tcgatcaaag cagtgcagaa agaaactggc 111961 cataaaggga aaaaactgtt tatgccgatt cgtgttgctg taacagggca aactcacggt 112021 ccggaactgc cgcaatcaat tgaattgatc ggtaaagaga ctgcaattca gcgtttaaag 112081 aatatctaaa taaatgattg ttgacaggga agagtataaa gctttaggcc attacagaaa 112141 ggatcttcat tggctgagag agatccatga gccgggtttt agaagtgcgc ccttaagacc 112201 tttgaagaac gttttttgaa atcagtattc aaaggcggcc gccgccgtta caggctgaag 112261 ttgggagagc agaagtctgc ttttcaaaca gagtggaacc gcgcggttaa agcgtctctg 112321 tcatgtttac atgcagagac gcttttttta ttgggtagag gaaatcagat agagaaacgg 112381 ggggaagcat gtgtttttta gaatgctcaa agaagacatt gatactgtgt tcgatcaaga 112441 tcccgcagca agaagctatt ttgaagtgat tttaacttat tccggtttac atgctatatg 112501 ggcgcatcgg attgcacatg ctttatataa acgaaaattt tatttccttg cacgccttat 112561 atctcaagta agccgatttt ttaccgggat agaaatccac cccggcgcta caatcgggag 112621 aagatttttc atagaccacg gcatgggggt tgtcattggg gagacatgtg aaatcggcaa 112681 taacgtaacc gtttttcagg gggttaccct cgggggaacg ggaaaagaaa agggaaaaag 112741 gcacccaacg attaaagatg acgcattgat agccacaggt gctaaagtgc tcggttctat 112801 tacggtcggt gaaggctcaa agattggcgc tggttcagta gtgctgcatg atgttcctga 112861 tttttcaaca gttgtcggta tccctggacg ggtcgttgta caaaatggca agaaagtaag 112921 acgcgattta aaccatcagg atttgcccga tccagttgct gaccgcttta agtctttgga 112981 acagcagatt ttagagctga aggcagaact tgaagacaga aaagaaagga tcaatcaaaa 113041 atgacaatca cactttataa tacattgact agacagaagg aaacattcgt tcctcttgaa 113101 gagggaaaag tgaaaatgta tgtatgcgga cccacggttt acaattacat tcatatcggg 113161 aacgcgcgtc cggcaatcgt ttacgatacg gttcgaaact atttagagta taaaggctat 113221 gatgtgcagt atgtctctaa cttcacagac gtagacgata aattaattaa agcggcaaat 113281 gaactcggtg aggatgtacc caccatttca gagcgtttta ttaaagcata ctttgaagac 113341 gtaggtgcgc tcggctgccg aaaagccgac cttcatccgc gagtaatgga gaacatggat 113401 gccattatcg aattcgtaga tcagctcgtg aaaaagggct acgcatatga atcagaaggt 113461 gacgtatatt tcaaaaccag agcatttgaa gggtacggaa agctttctca gcaatcaatc 113521 gatgaactaa gatcaggtgc acgcatccgg gtcggcgaga aaaaagaaga tgctcttgat 113581 ttcgcactgt ggaaagcggc aaaagaagga gaaatctctt gggatagccc ttgggggaaa 113641 gggcgtccgg gctggcacat tgaatgctca gcaatggtga aaaagtatct cggtgaccag 113701 attgatatcc atgcgggcgg acaggattta acattccctc accatgaaaa cgaaattgcg 113761 caatctgagg cgctgacagg caaaacgttt gcgaagtact ggcttcataa tggttatatc 113821 aatattgata atgaaaaaat gtcaaaatca ctaggcaact ttgtgcttgt gcatgacatc 113881 attaaacagc atgatccgca gcttttgaga ttctttatgc tatctgttca ttatcgccat 113941 ccgattaact attcagaaga gcttctggag aatacgaaaa gcgcgttcag ccgtttaaaa 114001 acagcgtaca gcaatcttca gcaccgtctg aacagcagta cgaatttaac cgaagatgac 114061 gatcaatggc ttgaaaaggt tgaagaacac cgcaaagcat tcgaagaaga gatggacgat 114121 gattttaata cggcgaatgc catttcagtc ttgtttgact tagcgaaaca cgccaattat 114181 tatcttcaga aagatcatac ggctgatcat gtgattacgg cgtttattga gatgtttgac 114241 cgcattgttt ctgtcctcgg tttttcgttg ggtgagcagg aacttctcga tcaagagatt 114301 gaagacttaa tcgaaaagcg aaatgaagcg cgccggaatc gcgattttgc attgtcagac 114361 cagatccgcg accagctgaa aagcatgaat atcattcttg aagatacggc tcaaggcact 114421 cgctggaaac ggggagaata acagatgctt gaatttgata cgataaaaga ttctaagcag 114481 cttaacggtc ttgcgcttgc ttatataggt gatgccattt ttgaagtgta tgtcaggcat 114541 cacctgctta agcagggctt taccaaacca aatgatcttc ataagaaatc aagccggatt 114601 gtttcagcaa agtcacaggc tgagatccta ttttttctgc agaatcaatc attttttacg 114661 gaagaagagg aagcggtgct gaaaagaggc agaaatgcca agtcagggac aacacctaaa 114721 aatacagatg ttcagacgta ccgctacagt acagcatttg aagcgcttct gggctacctt 114781 tttctagaga aaaaagagga acgacttagt cagctcgtag ccgaagctat acaattcggg 114841 acgtcaggga ggaaaacaaa tgagtcagca acatgattac gtcataggga aaaatgcagt 114901 gatcgagacg ttaaaatctg atcggaagct gtataagctg tggatggcgg aaaacaccgt 114961 aaagggacaa gcacagcaag tgattgagct tgccaaaaag cagggaatca cgattcaata 115021 cgtcccgaga aaaaaactcg atcaaatggt gacaggacag catcagggcg tagtggcaca 115081 ggttgcagcg tatgaatatg cagaactgga cgatttatat aaagcagccg aagaaaaaaa 115141 tgaacagcct ttcttcctca ttctggacga gcttgaagac cctcataatc ttggttccat 115201 tatgaggaca gcagatgcgg tcggcgctca tggcatcgtc attccaaaac ggagagctgt 115261 cgggctgaca acaacagtgg caaaagcttc aacaggagca attgagcaca ttcctgtagc 115321 aagagtcacc aatttggcac ggacgttaga agagatgaaa gagcggggaa tctgggttgt 115381 cggaacggat gcgtccgcgc gtgaggattt ccgtaatatg gacggcaata tgcctttggc 115441 tctagtcatc ggaagtgaag gaaaagggat gggccgcctt gtgaaggaaa agtgcgattt 115501 tctcattaaa ctcccgatgg ccggaaaggt aacttcacta aatgcatctg tcgcggctgg 115561 tcttttgatg tatgaagtct accggaaacg aaaccctgtg ggagaataaa gacccatgga 115621 tatcctgtta gtagacgggt acaacatgat tggagcctgg ccgcagctga aggatttaaa 115681 agcgaacagt tttgaagagg cgagagacgt actgattcag aaaatggcgg aatatcaatc 115741 gtatacagga aacagggtta ttgttgtttt tgacgcgcat ctcgtaaaag ggcttgagaa 115801 aaaacagacc aaccatagag ttgaagtaat ttttacaaaa gaaaatgaga cggctgatga 115861 gcggatagaa aagctcgctc aggctttgaa taatattgcg actcaaattc acgttgcgac 115921 ctctgactat actgagcagt gggcgatttt cggacagggg gcattgcgga aatcggcccg 115981 ggagcttctg agagaggtag aaacgattga aaggcgaata gagagacggg taagaaaaat 116041 cacttccgaa aagccggcgg gtaaaattgc tttatcggaa gaggttttga aaacgtttga 116101 aaagtggagg cggggagact tagattaagt tgacgctttt ttgcccaata ctgtataata 116161 tttctatcta cgtgcgccgg ggggatcgga gtgaatctac agaacaacaa gggaaaattc 116221 aacaaagagc agttttgcca gttggaggac gagcaggtca ttgaaaaggt tcatgttggg 116281 gacagtgatg cgttagatta cttgattacg aagtaccgaa actttgttcg ggcaaaagca 116341 agatcctatt tcttaatagg ggcggacaga gaggatattg ttcaggaagg catgataggc 116401 ctctataagt ctattcgtga cttcaaagag gacaagctta cctcattcaa agcttttgca 116461 gaattatgta ttacccgcca aattattacc gcaataaaga cagctactcg ccagaaacac 116521 attcctttga attcctacgc ctcattagat aaaccgatct ttgatgaaga atcagaccga 116581 acgctgctgg atgtcatttc aggagcgaaa accttaaatc ctgaggaaat gatcattaat 116641 caggaagaat ttgatgatat tgaaatgaaa atgggagaac tattaagtga tttagagaga 116701 aaagtactcg tcttatatct cgacgggaga agttaccaag agatttctga tgaactgaac 116761 cgacatgtga aatcgatcga caatgccctt cagcgtgtga aacgcaagct ggagaagtac 116821 ttggaaattc gcgaaatcag tttgtaatag gaatttatgc tatattgaca gtatttttct 116881 gactatgata tgttactaaa gataagaact aatgtctatt tagaaaaagg tgtaatgaca 116941 tgagaaaaaa gattacgtta gcatgcaaga catgcggaaa ccgtaattat acgacaatga 117001 agagctctgc atcagcggct gagcgattag aagtaaagaa atactgcagt acttgcaatt 117061 cacatacagc tcatcttgaa acaaaatagt ttttgcgctt ttaaattgtg gaggtctttt 117121 acatgcgtat tatgaaattc tttaaagatg ttgggaaaga aatgaaaaag gtaagctggc 117181 ctaaaggaaa agagttaacg cgttatacca ttacggtaat ttcaacagtt atcttttttg 117241 ttatcttttt tgccctcctt gacacaggaa tttctcaatt aattcgttta atagttgaat 117301 aatgatcagc aatacgtgct ataatagatc ataatattac ttgccaaaac ccgttcagcg 117361 ggttttttat tgtggcttaa aatgaaagtt atcataggct tgccgcctat tttttgaagc 117421 gttatggtaa ttcactaaaa ccaaatgcgg ggagggaagg actggacagt cctgaataga 117481 atggaaaaga attggtatgt tgttcacacg tactctggtt atgagaataa agtaaaagcc 117541 aacttggaaa agcgtgttga atcaatgggg atgcaggata aaattttccg tgtagtcgta 117601 cccgaagaag aagaaacgga tatcaaaaac ggcaagaaaa aagtcgtgaa aaagaaagta 117661 ttccctggtt atgtgcttgt tgaaattgta atgacagacg actcttggta tgtcgtccgc 117721 aacacgccgg gcgttactgg attcgtagga tctgccgggt caggttcaaa accgacgccg 117781 cttcttccgg gggaagcaga aaccattctg aagagaatgg gcatggatga acgaaaaact 117841 gatattgact ttgaactgaa agagacagtg aaagtaatag acggaccttt tgctaacttt 117901 acaggatcaa ttgaagagat tgattatgat aaaagcaagg tcaaagtttt cgttaatatg 117961 tttggccgtg aaacgccggt tgagctggaa tttacccaaa tcgataaatt gtaatgtgaa 118021 aaaacttgaa attgctatat ataaatgata atatagcaaa ggtacgtctt ggacttatcc 118081 aaggcaacta gcatgatatt tcgtcattca tataaagaat gaaaccttga gtgggagggt 118141 ttaccctatt accacatcac ggacttaagg aggtgtgtct cgtggctaaa aaagtagtta 118201 aagttgtaaa attgcaaatt cctgctggaa aagctaaccc agcaccacca gttggacctg 118261 cacttggtca agccggtgtt aacatcatgg gattctgtaa ggagtttaac gctcgtacag 118321 ctgaccaagc tggtttaatc attcctgttg aaatttcggt ttacgaagac cgttcattta 118381 catttattac aaaaactcca cctgctgcag tattgcttaa aaaagcagct ggaattgagt 118441 ctggttctgg tgaaccaaac cgtaataaag tggcaaccgt taagcgcgat aaagtacgcg 118501 aaatcgctga aacgaaaatg cctgacttaa acgcagcaga cgttgaagcg gcaatgcgca 118561 tggttgaagg tactgcccgc agtatgggta ttgtaatcga ggattaattt gtttcttgtc 118621 gggttgcgag ttttaacaag ttcgcaaccc ttattcgtgg gaggttattc cgctataacc 118681 acataaggag gaaattttaa aatggctaaa aaaggtaaaa agtacgttga agctgctaag 118741 cttgtagacc gttctaaagc ttacgacgtc tctgaagcag tagctctcgt taaaaaaaca 118801 aacacagcta aattcgacgc tacagttgaa gtggctttcc gtttaggggt tgaccctcgt 118861 aaaaacgacc agcaaatccg tggagcagtt gtgcttccaa acggaactgg taaaactcag 118921 cgcgttctcg ttttcgcaaa aggcgaaaaa gcgaaagaag ctgaagctgc tggtgcagat 118981 ttcgtaggcg atactgacta catcaacaaa attcaacaag gctggttcga tttcgatgtt 119041 atcgtagcta cacctgacat gatgggtgaa gttggtaaaa tcggtcgtgt acttggacca 119101 aaaggtttaa tgccgaaccc taaaactggt acagttactt tcgaagttga aaaagctatc 119161 ggcgaaatca aagctggtaa agttgaatac cgcgttgata aagctggaaa cattcatgtt 119221 cctatcggta aagtttcttt cgaggatgaa aaacttgttg agaacttcac aacaatgtac 119281 gatacaatcc ttaaagctaa acctgctgca gctaaaggcg tttacgtgaa aaacgttgct 119341 gtaacttcta ctatgggacc tggtgtcaaa gtagactctt caacttttaa cgtaaaataa 119401 tattgacatg acatcaacat tctgatatta ttcaaaatgt tgtaaaatag aatatcattt 119461 ataccgtaga cagtaggggc ctaaccgctt aattatccta ccgaggtgta tattatcaca 119521 gctattacgt tacgtatgct tgtatataca gcctccatgt ctcatggagg ctttttatat 119581 ggaatccgtc gtctcagtcg tgatcaccta acggtataag tgttacacaa gaatctacag 119641 gaggtgtaac catgagcagc gcaattgaaa caaaaaaagt tgttgttgaa gaaattgctt 119701 ctaaactgaa agaaagtaaa tcaacgatca tcgttgacta tcgcggactt aacgtttctg 119761 aagtaactga acttcgtaaa cagcttcgcg aagctaacgt tgagttcaaa gtttacaaaa 119821 atacgatgac tcgccgtgcg gttgaacaag ctgagcttaa tggtttgaat gatttcttaa 119881 ctggaccgaa cgcgatcgca ttcagcactg aagatgttgt cgctccggct aaagttctta 119941 atgacttcgc taaaaatcac gaagctcttg aaatcaaagc tggcgttatc gaaggtaaag 120001 tttctactgt tgaagaagtg aaagctcttg ctgaacttcc atcacgcgaa ggcttgcttt 120061 ctatgttgct tagcgtactt caagctccag ttcgcaacct tgctcttgct gcaaaagctg 120121 tggcagaaca aaaggaagaa caaggcgctt aatctaatca gtttttcata aattaaaaca 120181 aaatggagga attacaaatg gctttaaata tcgaagaaat cattgcttcc gttaaagaag 120241 caactgtact tgaattgaac gacctagtaa aagcaatcga agaagaattt ggcgtaactg 120301 ctgctgctcc tgtagctgta gctggcggag ctgctgctgg cggagctgct gaagagcaaa 120361 gcgaattcga tcttatcctt gctggtgcag gatctcaaaa aatcaaagtt atcaaagttg 120421 tacgtgaaat cactggtctt ggcttgaaag aagctaaaga gcttgttgac aacactccaa 120481 aaccacttaa agaaggtatt gctaaagaag aagctgaaga gcttaaagct aaacttgaag 120541 aagttggcgc ttctgtagaa gttaagtaat cttcacttac ctgtagggga agctcgcttt 120601 tatgaggcga gctttttctt tgccattctt taagccatga aaaaaggagg ttctaataat 120661 gagtgagcac tattattcag aaaaaccttc agtaaaaagc aacaagcaaa cctggtcttt 120721 taggcttcgg aataaagatt tcacgtttac cagcgacagc ggggtttttt ctaaaaaaga 120781 agttgatttc ggctcccgcc tgctgattga ttcttttgaa gagcctgagg ttgagggcgg 120841 cattttagat gtaggctgcg gatacggccc gattggttta tcgctcgcca gcgactttaa 120901 agaccggacc atccacatga ttgacgttaa tgagagagcc gtagaactat caaatgaaaa 120961 tgcggaacag aacggaataa caaacgttaa gatttatcaa agcgatttgt tttcaaacgt 121021 tgattctgct caaacatttg cttctattct tacaaatccc ccaatccgag ccggaaaaaa 121081 agttgtccat gctatctttg agaaaagcgc tgaacactta aaagcttcag gtgaattgtg 121141 gatcgtcata cagaaaaagc aaggcgcgcc ttctgccatt gaaaagctcg aggaactgtt 121201 cgatgaagtt tccgtcgttc aaaaaaagaa aggctattat atcataaaag caaaaaaagt 121261 ttgactcggt attttaacta tgttaatatt gtaaaatgcc aatgtatata ttttgcttga 121321 tatgatgaat tgtcaatatc tatgtataaa ttatacaagt atggaaatgc taataaaatc 121381 ggtatttgtt tttggatgtg gttttcttaa ttagaaaccc ttttttcttt tgtcttgtaa 121441 aagtattttc tttctttgga agaaatgctt attacacata taatacgcat gatttgaggg 121501 gtgaatcagt tgacaggtca actagttcag tatggacgac accgccagcg cagaagctat 121561 gctcgcatta gcgaagtgtt agaattacca aatctcattg aaattcaaac ctcttcttat 121621 cagtggtttc ttgatgaggg tcttagagag atgtttcaag acatatcacc aattgaggat 121681 ttcactggta acctctctct tgagttcatt gattatagtt taggtgagcc taaatatcct 121741 gtagaggaat caaaagaacg tgatgtgact tactcagctc cgctaagagt gaaggttcgt 121801 ttaattaaca aagaaactgg agaggtaaaa gaccaagatg tcttcatggg tgatttccct 121861 attatgacag atacaggtac ttttatcatt aacggtgcgg aacgtgttat cgtttcccag 121921 cttgttcggt ctccaagtgt atatttcagt ggtaaagtag acaaaaacgg taaaaaaggt 121981 tttaccgcaa ctgtcattcc aaaccgtggc gcatggttag aatacgaaac tgatgcgaaa 122041 gatgttgttt atgtccgcat tgatcgcaca cgtaagttgc cggttacggt tcttttgcgt 122101 gctctcggct tcggctccga tcaagagatt cttgatctca taggagaaaa cgaatacctg 122161 cgaaatacgc ttgataaaga taacacagaa aacagcgaca aagcgttgct ggaaatttac 122221 gagcgtctcc gtcctggaga gccgcctaca gtagaaaatg cgaaaagctt gcttgattct 122281 cgtttctttg atccgaaacg atacgatctt gccaatgtag gacgctataa aattaataaa 122341 aaacttcata ttaagaatcg cctcttcaat cagagacttg ctgaaacgct tgttgatcct 122401 gaaacaggag aaatccttgc tgaaaaaggc cagattcttg atagaagaac gcttgataaa 122461 gtactgccat acttagaaaa cggaatcggt tttagaaagc tgtatccgaa tggcggcgtt 122521 gttgaagatg aagtgactct tcaatcaatt aaaatctttg ctccgactga tcaagaagga 122581 gaacaggtta tcaatgtaat cggcaatgct tacatcgaag aagagattaa aaacatcacg 122641 cctgctgata ttatttcttc aatcagctac ttcttcaacc tgctgcacgg agtaggcgac 122701 acagatgata tcgatcatct tggaaaccgc cgtttacgtt ctgtaggcga gcttctccag 122761 aaccaattcc gtatcggttt aagccgtatg gagcgtgtgg ttcgtgagag aatgtcaatt 122821 caagatacga atacaattac gcctcagcag ctgatcaata ttcgtcctgt tattgcgtcc 122881 attaaagagt tctttggaag ctcacagctt tctcaattca tggatcagac gaacccgctt 122941 gctgaattaa cgcacaagcg tcgtctgtca gcattaggac cgggcggatt gacacgtgag 123001 cgtgccggaa tggaagtgcg tgacgttcac tactcccact atggccgtat gtgtccgatt 123061 gaaacgcctg agggcccgaa catcggtttg atcaactcac tatcatctta tgcaaaagta 123121 aaccgttttg gctttattga aacgccatat cgccgcgttg accctgaaac agggaaggta 123181 acgggcagaa tcgattactt aactgctgat gaagaggata actatgttgt cgctcaagcg 123241 aatgctcgtc ttgatgacga aggcgccttt attgatgaca gcatcgtagc tcgtttccgc 123301 ggggagaaca ccgttgtttc cagaaatcgt gtagactaca tggatgtatc gcctaagcag 123361 gttgtatctg ctgcgacagc atgtatcccg ttcttagaaa acgatgactc caaccgtgcc 123421 ctcatgggag cgaacatgca gcgtcaggct gtgcctttga tgcagccgga agcgccattt 123481 gttggaactg gtatggaata cgtatcagga aaagactctg gtgccgctgt tatttgtaaa 123541 caccctggta tcgttgaacg cgtagaagcc aaaaacgttt gggttcgccg ttatgaagaa 123601 gtagacggtc aaaaagtaaa aggaaacctg gataaataca gcctgctgaa atttgtccgc 123661 tctaaccaag gtacgtgcta caaccagcgt ccgatcgtaa gtgtcggcga tgaagtggta 123721 aaaggagaaa tccttgctga cggtccttct atggagcttg gtgaacttgc acttggccgt 123781 aacgtaatgg tcggcttcat gacgtgggat ggctacaact atgaggatgc catcatcatg 123841 agtgaacgcc tagtgaagga tgatgtttat acatctatcc acattgaaga atacgaatca 123901 gaagcacgtg atacgaaact tggacctgaa gaaatcactc gcgatattcc aaacgtcggt 123961 gaagatgcgc ttcgcaatct tgatgaccgc ggaatcatcc gtattggggc agaagtaaaa 124021 gacggagatc ttcttgttgg taaagtaacg cctaaaggcg taactgaact gactgccgaa 124081 gaacgccttc ttcacgccat ctttggcgag aaagcccgcg aggttcgtga tacttctctt 124141 cgtgtgcctc atggcggcgg cggaattatc catgacgtta aagtcttcaa ccgtgaagac 124201 ggagacgaac ttcctccagg tgttaaccag ttagtacgcg tatatatcgt tcagaaacgt 124261 aagatttctg aaggggataa aatggccggt cgtcacggta acaaaggtgt tatctctaag 124321 attcttcctg aagaggatat gccttacctt cctgacggca caccaattga tatcatgctt 124381 aacccgctgg gcgtaccatc acgtatgaac atcgggcagg tattggaact tcacatgggt 124441 atggccgctc gttaccttgg cattcacatt gcatctcctg tatttgacgg agcgcgagaa 124501 gaggatgtct gggaaacact tgaagaagcc ggcatgtctc gtgacgccaa aacagtgctt 124561 tacgacggac gtactggaga gccgtttgat aaccgtgtat ctgtcggtat catgtacatg 124621 atcaaactgg ctcacatggt tgacgataaa cttcatgcac gctctacagg cccttactca 124681 cttgttacgc agcagcctct tggcggtaaa gcgcaatttg gcggacagcg ttttggtgag 124741 atggaggttt gggcacttga agcttacggt gcggcttaca ctcttcaaga aattctgact 124801 gttaagtctg atgacgtggt tggacgtgtg aaaacatacg aagccatcgt taaaggcgac 124861 aatgttcctg aaccaggtgt tccggaatca ttcaaagtat taatcaaaga acttcaaagc 124921 ttaggtatgg atgtcaaaat cctttctggt gatgaagaag aaatagaaat gagagattta 124981 gaagacgaag aagatgcgaa acaagctgac ggcctggcat tatcaggtga tgaagagccg 125041 gaagaaacag catctgcaga cgttgaacgc gatgtagtaa caaaagaata atctctagtt 125101 ataaaggcaa gtgacatcgg ttaatccgaa gataaaaagg gaggtaggcc ccttgctaga 125161 tgtgaacaat tttgagtata tgaacatcgg tcttgcttca ccagataaaa tccgttcatg 125221 gtcttttggt gaagtgaaaa agcctgaaac gataaactat cgtacgttaa aacctgaaaa 125281 ggacggtcta ttctgcgaac gcattttcgg accgactaag gactgggaat gtcattgcgg 125341 gaagtacaag cgagttcgtt ataaaggcgt agtttgtgac cgctgcggag tcgaagtaac 125401 acgggctaaa gtccgtcgtg agagaatggg gcacattgaa ctggctgccc cagtttccca 125461 catttggtat ttcaaaggta ttccaagccg tatgggtctt gtgctggata tgtcacctcg 125521 tgctttagaa gaagtcattt actttgcttc ttacgttgta actgatccgg cgaatacacc 125581 gcttgaaaag aaacagcttc tgtctgagaa agaataccgt gcttatcttg ataaatacgg 125641 taataaattc caagcatcta tgggtgctga agcaattcat aaacttcttc aagatatcga 125701 tcttgtaaaa gaagttgata tgttaaaaga agagctgaaa acttcacaag gacaacgccg 125761 tactcgtgcg atcaaacgtc ttgaagtttt agaagccttc cgtaactcag gaaacaagcc 125821 ttcttggatg atccttgatg tgcttcctgt tattcctccg gagcttagac cgatggttca 125881 gctagatggc ggacgttttg cgacttctga tttgaatgac ctttatcgtc gtgtcatcaa 125941 ccgtaacaat cgtttgaaac gccttttgga ccttggtgcg cctagcatca tcgttcaaaa 126001 cgaaaagcgt atgcttcaag aggctgtcga tgccctaatt gacaacggcc gccgcggacg 126061 ccctgtaaca ggtcctggaa acagaccgtt aaaatctctt tctcacatgc tgaaagggaa 126121 gcaaggccgt ttccgtcaaa accttcttgg taaacgtgtc gattactccg gacgttctgt 126181 aatcgttgtt ggtcctcatt tgaaaatgta ccaatgcgga ttaccgaagg aaatggcact 126241 tgaacttttc aaacctttcg ttatgaaaga acttgttgaa aaaggtcttg ctcacaacat 126301 taagagtgcg aaacgcaaaa ttgagcgcgt acagcctgaa gtttgggatg tactagaatc 126361 agttattaag gagcatccgg tactgctgaa ccgtgcccct acacttcaca gattaggtat 126421 ccaggcgttt gaaccaacgc ttgttgaagg acgcgcaatc cgtcttcacc cgctcgtatg 126481 tacagcttac aacgctgact ttgacggtga ccaaatggcg gttcacgtac cattatctgc 126541 tgaagcacaa gctgaagcac gcatcttgat gcttgctgct caaaacatct tgaaccctaa 126601 agatggtaaa ccggttgtaa caccgtctca ggatatggta ctaggtaact attacctgac 126661 acttgagcgt gccggtgctg tcggtgaagg tatggtcttc aagaatacag acgaagcgct 126721 tcttgcttat caaaacggat atgttcacct tcatacgaga gtagctgttg cagctaactc 126781 acttaagaat gtgacattta ccgaagaaca gcgctcaaaa ttgttaatta caactgtcgg 126841 taagcttgtc ttcaatgaaa ttcttccgga atcattccct tacatgaatg aaccaacgaa 126901 gagcaacatt gaagagaaaa cacctgaccg tttcttctta gaaaaaggtg ctgatgttaa 126961 agctgttatc gcacagcagc caatcaatgc gccgtttaaa aaaggcattc tgggtaaaat 127021 catcgcggaa atctttaaac gattccatat tacggaaacg tctaaaatgc ttgaccgcat 127081 gaaaaaccta ggtttcaaat attcaactaa agctggtatt acagttgggg tttctgacat 127141 cgtcgtactc gatgataaac aagaaattct tgaggaagcg caaagcaaag ttgacaacgt 127201 tatgaagcaa ttccgccgcg gtcttatcac tgaagaagaa cgctatgaga gagtcatctc 127261 tatctggagt gctgcaaaag acgttatcca aggcaaactg atgaaatcac ttgatgaact 127321 caacccgatc tacatgatga gtgactctgg tgcccgtggt aacgcatcta actttacgca 127381 gcttgccgga atgcgcggcc tgatggccaa cccggctgga cgtatcattg agttgccgat 127441 caaatcaagt ttccgtgaag gtctgacagt attggagtac tttatctcca cacacggtgc 127501 gcgtaaaggt cttgccgata ccgctcttaa aactgctgac tcaggttacc ttacacgccg 127561 tctcgttgac gttgctcagg atgttatcat ccgtgaaact gattgcggaa ctgaccgagg 127621 cattcttgct aagcctctta aagaaggaac tgaaacaatt gagcgcttag aagaacgctt 127681 aatcggacgt tttgcaagaa aacaagtgaa gcaccctgaa acaggtgaag tgcttgtgaa 127741 tgaaaacgaa ctgatcgatg aagataaagc actggagatt gtcgaagccg gcattgaaga 127801 agtgtggatc cgttctgcct tcacatgtaa tacgcctcat ggtgtatgta aacgatgcta 127861 tggccgaaat cttgcaactg gctccgatgt tgaagtcggt gaagctgtcg gaatcattgc 127921 tgcccaatca atcggtgagc ctggtacaca gttaacaatg cgtacattcc atacaggcgg 127981 ggttgccgga gacgatatca cacagggtct tccgcgtatc caagagcttt tcgaagcgcg 128041 taatccgaaa ggtcaggcaa caattacaga aatcgacggt acagtcgttg agatcaatga 128101 agttcgtgat aagcaacagg aaattgtggt tcaaggcgca gtggaaacac gttcttatac 128161 ggcaccttac aactcccgcc tgaaagtagc ggaaggagat aaaattactc gaggccaagt 128221 actgacagaa ggttcaatcg atccgaaaga acttcttaaa gtgactgacc tgacgactgt 128281 tcaagagtat cttctccatg aggttcaaaa ggtttaccgt atgcagggtg ttgaaatcgg 128341 tgataaacac gtagaagtaa tggttcgcca gatgcttcgc aaagtacgcg tgattgatgc 128401 cggtgacact gatgtgcttc caggtacatt gcttgatatt caccaattta ctgaagcgaa 128461 caaaaaggta ttgcttgaag gcaaccgacc agctacaggc cgtcctgtct tactcggtat 128521 tacaaaagca tctcttgaaa ctgattcatt cttatctgct gcttccttcc aggaaacaac 128581 acgtgtcctt acagatgcag cgatcaaagg taagcgtgac gagcttctcg gcttgaaaga 128641 gaatgttatc atcggtaagc ttgttccagc aggtacagga atgatgaaat accgtaaagt 128701 aaaaccagta tcaaatgttc agccgactga cgatatggtc ccggttgaat aactgattta 128761 actctgctga aagactgcaa aaacagtctt tcagcagata tatttatgaa aaagtcactc 128821 tatgagaaga acgaatctaa aaaatgtcat accttgttga cattcgtctc ctagaatgat 128881 aatataacca aggtgctcga aataaacctg ttactttgga ggatatgttt atgtcttatg 128941 ataaagtatc acaggccaaa tcaattatta ttggtacgaa gcaaacagtg aaagctctaa 129001 agcgaggttc agtaaaggaa gtagtcgttg caaaagacgc agatccgata ctcacgtcaa 129061 gtgttgtttc acttgctgaa gatcaaggta tctctgtctc aatggttgaa tccatgaaaa 129121 agctcggcaa agcctgcgga attgaggtag gagcagccgc tgttgccatt attttataac 129181 gtacttttgt ttttgcgtaa gattccatct tgtgtaaaga cattgttttt tgccttttga 129241 tgaaccacct gggtatgtgg gttataaaac gtaatgaagg gaggaaaaat tcatgcctac 129301 aattaatcag ctaattcgca aaggacgcgt gagtaaagta gaaaactcaa agtctcctgc 129361 acttaacaaa ggatacaaca gctttaaaaa agagcacact aacgtatctt ctccacaaaa 129421 acgcggggta tgtactcgtg ttggtacaat gacaccgaaa aaaccgaact cagcacttcg 129481 taaatatgct cgtgttcgtt tgactaacgg aatcgaggtt actgcttaca ttcctggtat 129541 cggtcacaac ctgcaagagc acagtgttgt acttatccgc ggcggacgtg taaaagactt 129601 accaggggta cgttaccaca tcgttcgtgg tgcgcttgat actgctggag ttgaaaaccg 129661 tgcacaaggc cgttctaaat acggtacgaa aaaacctaaa gcaaaataat atacgaaaat 129721 acgcataatt gatgaaggga ggatattcag atgccacgta aaggtcctgt agcaaaaaga 129781 gatgttttac ctgatccgat ttacaactct aagcttgtat ctcgtttaat caacaaaatg 129841 atgatcgatg gtaaaaaagg taagtctcaa acgatcctat acaagtcatt cgatatcatt 129901 aaagaacgta ctggcaatga tgcaatggag gttttcgaac aagcattgaa aaacatcatg 129961 cctgtacttg aagtaaaagc acgccgtgta ggtggtgcga actaccaagt tcctgtagaa 130021 gttcgtcctg aacgtcgtac gactcttgga cttcgctggt tagttaacta cgctcgtctt 130081 cgtggagaaa aaacgatgga agagcgttta gctaacgaaa tccttgacgc agctaacaac 130141 actggtgctg ctgttaagaa acgtgaagac actcataaga tggctgaagc aaacaaagca 130201 tttgctcact atcgctggta ggatttatag attaacaaaa cacaatttcc taataaggaa 130261 ggagaaatta cccaatggca agagagttct ccttagaaaa aactcgtaat atcggtatca 130321 tggctcacat cgatgccggt aaaacgacta ctacagaacg tatcttgttc tatactggtc 130381 gtatccacaa aattggtgaa actcatgaag gagcttcaca aatggactgg atggagcagg 130441 aacaagaacg tggtatcaca atcacttccg ctgcgactac tgcacagtgg aaaggatacc 130501 gcgtaaacat catcgatact ccaggacacg tagacttcac agttgaagtt gaacgttctc 130561 ttcgtgtact tgatggtgct gttgctgtac ttgacgcgca atcaggcgtt gagcctcaaa 130621 cagaaactgt ttggcgtcag gcaacaactt atggagtacc gcgtatcgtt tttgttaaca 130681 aaatggacaa aatcggtgca gacttccttt actctgtagg aactttaaga gaccgtcttc 130741 aagcaaacgc tcatgcaatt caattgccga tcggtgctga agataacttc gaaggtatca 130801 ttgaccttgt agaaaacgtt gcgtatttct acgaagatga cctcggaact cgttctgatg 130861 caaaagaaat ccctgaagag tacaaagagc aagctgaaga gcttcgcaac agccttattg 130921 aagctgtatg tgagcttgat gaagagctta tggataagta ccttgagggt gaagaaatca 130981 caattgacga gttaaaagca ggaattcgta aaggtacatt aaatgttgaa ttctaccctg 131041 ttcttgttgg ttctgccttc aaaaacaaag gtgttcaact agtacttgat gctgttcttg 131101 actaccttcc tgcaccaact gacgttgctg caatcaaagg tacacgtcct gatacaaatg 131161 aagagattga gcgtcattct tctgacgaag agccattctc tgcattagca tttaaagtta 131221 tgactgaccc ttacgttggt aagttgacgt tcttccgtgt gtactctgga acacttgatt 131281 ctggttcata cgtgaaaaac tctactaaag gcaaacgtga gcgtgttgga cgtattcttc 131341 aaatgcacgc taacagccgt gaagaaatct ctactgtata cgcaggggat atcgcagctg 131401 ctgtaggtct aaaagataca actactggag atactctatg tgatgagaag gatcttgtta 131461 tccttgagtc aatggaattc ccagaaccag ttatcgacgt tgctattgag cctaaatcaa 131521 aagctgacca agataaaatg ggtatcgctt tagcgaaact tgctgaagaa gatcctacat 131581 tccgtactca aacaaaccca gaaactggcc aaacgatcat ctctggtatg ggtgaacttc 131641 accttgatat cattgttgac cgtatgaaac gcgaatttaa agtagaagcc aatgttggtg 131701 ctcctcaagt tgcgtaccgt gaaacattcc gtaccggtgc aaaagttgaa ggtaaattcg 131761 tacgtcagtc tggtggacgc ggtcagttcg gacacgtttg gatcgaattc gaaccaaacg 131821 aagaaggcgc tggctttgaa tttgaaaatg cgattgtcgg tggggtcgtt cctcgtgaat 131881 acatcccagc tgttcaagca ggtctggaag atgcactcga aaatggtgta ctagcaggct 131941 tcccgcttat cgacattaaa gctaaacttt tcgacggttc ttaccatgat gttgactcaa 132001 acgaaatggc atttaaagtc gctgcttcta tggcattgaa aaatgcagtc agcaaatgta 132061 acccagttct tcttgaacca atcatgaaag tggaagtggt tattccagaa gaatatatgg 132121 gagatatcat gggtgatatc acttcacgtc gcggacgcgt agaaggtatg gaagcacgcg 132181 gtaacgctca agttgttcgt gctatggttc ctcttgctga aatgttcggt tacgctactg 132241 cacttcgttc taatacgcaa ggtcgcggta cgttcactat gcacatggat cactacgaag 132301 aagtgccgaa gagcgtcgca gaagaaatta tcaaaaaaaa taaaggcgaa taattgattt 132361 tgccgcttaa ctcaagtata actactattg taagatgagg aagtgaaagc tttctttcac 132421 ttcctatcac tctatacatt actaattaaa agctcttaag gaggatttta gaatggctaa 132481 agaaaaattc gaccgttcca aatcacatgc caatattggt acaattggac acgttgacca 132541 tggtaaaaca actttaactg ctgctatcac aacagtactt cataagaaat ctggtaaagg 132601 tacagctatg gcgtacgatc aaattgatgg tgctccagaa gaacgcgagc gcggtatcac 132661 aatctctact gcacacgttg agtacgaaac tgaaactcgt cactatgcac acgttgactg 132721 cccaggacac gctgactatg ttaaaaacat gatcactggt gctgcgcaaa tggacggagc 132781 tatccttgta gtatctgctg ctgatggccc aatgccacaa actcgtgagc acatccttct 132841 ttctaaaaac gttggtgtac catacatcgt tgtattctta aacaaatgcg acatggtaga 132901 cgacgaagag cttcttgaac tagttgaaat ggaagttcgc gatcttctta gcgaatacga 132961 cttccctggt gatgatgtac cagttgttaa aggttctgct cttaaagctc ttgaaggaga 133021 cgctgagtgg gaagctaaaa tcttcgaact tatggatgcg gttgatgagt acatcccaac 133081 tccagaacgc gacactgaaa aaccattcat gatgccagtt gaggacgtat tctcaatcac 133141 tggtcgtggt acagttgcta ctggccgtgt agaacgcgga caagttaaag tcggtgacga 133201 agttgaaatc atcggtcttc aagaagagaa caagaaaaca actgttacag gtgttgaaat 133261 gttccgtaag cttcttgatt acgctgaagc tggtgacaac attggtgccc ttcttcgcgg 133321 tgtatctcgt gaagaaatcc aacgtggtca agtacttgct aaaccaggta caatcactcc 133381 acacagcaaa ttcaaagctg aagtttacgt tctttctaaa gaagagggtg gacgtcatac 133441 tccattcttc tctaactacc gtcctcagtt ctacttccgt acaactgacg taactggtat 133501 catccatctt ccagaaggcg tagaaatggt tatgcctgga gataacactg aaatgaacgt 133561 tgaacttatt tctacaatcg ctatcgaaga aggaactcgt ttctctattc gtgaaggcgg 133621 acgtactgtt ggttcaggcg ttgtttctac aatcactgag taatagtatg gttttaaacg 133681 agacccctgt gggtctcgtt ttttgtttgc ttatcttttt cttgtataat aggatctatc 133741 atattcgagg ggttaatatt tatgattcct gaaaagaaat caatcgcaat catgaaagaa 133801 ctaagcattg gaaatacaaa gcaaatgctg atgattaatg gagttgacgt gaaaaatcca 133861 ttgctgcttt ttttacatgg cgggccggga acgccgcaaa tcggatatgt tagacattat 133921 caaaaagagc tggaacagta ttttacagta gttcattggg atcagagagg atcggggctt 133981 tcttattcta agcgaatttc gcatcactct atgacaataa atcacttcat taaagataca 134041 atccaagtca ctcaatggct tttagctcat ttttcaaaat caaaacttta cctagccggt 134101 cattcttggg gatcaatact ggcgcttcat gtgctgcagc agcgtcctga tttattttac 134161 acgtattatg gaatcagcca ggttgttaac ccgcaagatg aagaatcaac tgcttatcaa 134221 catattcgtg aaatttccga atcaaaaaaa gccagcatat tatctttcct tacacgtttc 134281 attggtgctc cgccttggaa gcaggatatc cagcacctta tctatcggtt ttgtgttgag 134341 ctaaccaggg gaggattcac tcaccgtcat cgtcaatctc tcgctgtatt atttcaaatg 134401 cttactggca atgagtatgg agtgcggaac atgcacagct tccttaatgg attgcgcttc 134461 agtaaaaaac atttaactga tgagttgtac cggtttaatg cttttacatc agttccttct 134521 attaaagtac cgtgtgtttt catttcaggg aaacatgact taattgttcc tgcagaaata 134581 tcgaaacagt attatcaaga acttgaggca cctgaaaagc gctggtttca atttgagaat 134641 tcagctcaca ccccgcatat tgaggagcca tcattattcg cgaacacatt aagtcggcat 134701 gcacgacacc atttatgata gatccttgat aaataagaaa aacccctgta taataaaaaa 134761 agtgtgcaaa tcatgcatat tttaaataag tcttgcaaca tgcgcctatt ttctgtataa 134821 tggtgtatgt tggtctttga ctgcgatgaa gtgagaggtt gctgacacac ccggccgctt 134881 tgccatggca aggtgttcag gtttttctca cggagaactg tctaacgtga tgtaggcgaa 134941 aaggagggaa aataatggca aaacaaaaaa ttcgtattcg tttgaaagca tatgatcata 135001 gaatccttga tcaatctgca gagaagattg ttgaaacggc aaaacgttct ggtgccagcg 135061 tatctggtcc gattccgttg ccaactgaaa aatcagttta cacaatcctt cgtgcggtgc 135121 acaaatacaa agattctcgt gagcaatttg aaatgcgtac acataaacgt ttaatcgaca 135181 ttgtgaaccc aacaccacaa actgttgatg ctcttatgcg attagactta ccatctggtg 135241 tcgatatcga aattaaactt taattctaaa atatagaatg atcttaatag gaggtgtgac 135301 gaatgaccaa aggaatctta ggaagaaaaa ttggtatgac gcaagtattc gctgagaatg 135361 gtgatcttat tccggtaact gttatcgagg ctgctccaaa cgttgttctt caaaagaaaa 135421 cagctgaaaa cgacggttac gaagcaatcc agcttggttt tgacgacaag cgtgaaaagc 135481 tttctaacaa acctgaaaaa gggcacgttg caaaagcgga aactgctcct aagcgcttcg 135541 ttaaagaatt acgcggagtg gaaatggatg cgtatgaagt tggtcaggaa gtcaaggttg 135601 aaattttctc tgctggagaa atcgtagatg taacaggagt atctaaaggt aaaggtttcc 135661 aaggtgcgat caagcgccac ggacaatctc gcggacctat gtctcacggt tcacgctacc 135721 accgtcgtcc tggttcaatg ggacctgtag atcctaaccg tgtattcaaa ggtaaattat 135781 tacctggacg tatgggcgga gagcaaatca ctgttcaaaa ccttgaaatc gtaaaagttg 135841 atgcagaacg caatcttctt ttgatcaaag gtaacgtacc tggtgcgaag aaatctttaa 135901 tcactgttaa aagtgctgtt aaatctaaat aattctctta ggaaaggagg aaattgatta 135961 tgccaaaagt agcattatac aaccaaaacg gttctactgc tggtgacatc gaattaaacg 136021 cttctgtatt tggtatcgaa ccaaatgaga gtgttgtatt cgacgctatt cttatgcaaa 136081 gagcttcctt acgtcaagga actcacaaag taaaaaatcg ttctgaagta cgcggcggag 136141 gtcgtaaacc atggcgtcaa aaaggtactg gacgtgcccg tcaaggttca atccgttcac 136201 cgcaatggcg cggaggtggt gtcgtattcg gcccaacacc acgcagctat tcttataaat 136261 tacctaaaaa agttcgccgc ttggcaatca aatcagtatt gtcttctaaa gtgatcgaca 136321 acaacatcat cgttcttgaa gatcttactc ttgatacggc taaaacaaaa gaaatggcag 136381 ctatccttaa aggattatct gttgagaaaa aagctttaat cgtaactgcg gatgcaaacg 136441 aagcagtagc attatctgct cgtaacattc ctggagttac tgttgttgaa gctaacggaa 136501 tcaacgtttt agacgttgtc aaccacgaga agcttctgat tacaaaagca gcggttgaaa 136561 aagtagagga ggtgcttgca taatgaaaga tcctcgtgat gttctaaagc gccccgtcat 136621 tactgaacgt tctgccgatt taatgactga aaaaaaatat acttttgaag ttgatgtaag 136681 agctaacaaa acagaagtga aagacgcggt tgaaagcatc tttggagtga aagttgacaa 136741 agtcaacatc atgaactaca aaggcaaatc aaaacgtgtt ggacgctaca ctggtatgac 136801 tagccgtcgc agaaaagcga tcgtaaaact tactgcagac agcaaagaaa tcgaaatttt 136861 tgaagcttaa ttatctgtaa aaagaaggag ggaaattcaa aatggcgatt aaaaagtata 136921 aaccgacctc taatggacgt cgtggcatga caacttcaga ttttgctgaa atcacgactg 136981 acaagccgga aaaatccttg cttgctcccc ttcacaaaaa aggcggacgt aacaaccaag 137041 gtaaattgac tgtacgtcac caaggtggcg gacataaacg ccaataccgt gttatcgact 137101 tcaaacgcga taaagatggt atacctggac gcgttgctac agttgaatac gatccaaacc 137161 gttcagctaa catcgctcta atcaactatg cagacggaga aaaacgttac attcttgctc 137221 ctaaaggaat tcaagtaggt actgaaatca tgtcaggtcc tgaagctgac attaaagtag 137281 gtaatgcact tccacttatc aacatccctg ttggtacagt tgtgcataac attgaattaa 137341 aacctggtaa aggcggacag cttgtacgtt cagctggtac atctgctcag gttcttggta 137401 aagaaggtaa atacgttctt gtacgtctta actctggtga agttcgcatg atcctttctg 137461 cttgccgtgc ttctatcggt caagtaggta acgaacagca cgaacttatc aacattggta 137521 aagctggacg ttctcgctgg aaaggcatcc gtcctacagt tcgtggttct gtaatgaacc 137581 ctaacgatca cccacacggt ggtggtgaag gacgtgcgcc aatcggacgt aaatcaccaa 137641 tgtctccatg gggcaaacca actcttggat tcaagactcg taagaaaaag aacaaatccg 137701 ataaatttat cgtacgtcgt cgtaaaaata aataacgggg ttgtctacgg ttcttttcgg 137761 accgtagtgc aatcacgaag ggaggttcca aaatggctcg cagcttaaaa aaaggaccat 137821 ttgtcgatgg acacttgatg actaaaatcg agaaattaaa tgaaacagac aagaaacaag 137881 tcgtaaaaac ttggtctcgt cgttctacta ttttcccaca gtttattggt cacacaatcg 137941 cagtctatga cggacgtaaa cacgtgcctg tattcatctc tgaagatatg gtagggcaca 138001 agttgggtga attcgctcca actcgtacgt acaaaggtca tgctagtgat gacaaaaaaa 138061 caagacgcta agagaggagg cttttaaatg caagctaaag ctgttgcaag aacagtccgt 138121 attgctcctc gtaaagcacg tctagtaatg gacctgattc gaggcaagca agtaggtgag 138181 gcagtatcaa tcttgaacct tacaccaaga gctgcttctc caattatcga gaaagtatta 138241 aaatccgcta ttgcaaatgc tgagcataac tatgaaatgg acgctaacaa cctggttatt 138301 tctcaagcat tcgttgacga aggccctacg ttaaaaagat tccgcccacg tgctatggga 138361 cgtgcgagcc aaatcaacaa acgtacgagc cacattacaa tcgttgtatc agaaaagaag 138421 gagggataag tagtgggtca aaaggtaaat ccagtcggtc ttcgtatcgg agtcattcgt 138481 gattgggaat ctaagtggta cgctggtaaa gattacgctg acttcctgca cgaagattta 138541 aaaattcgtg aatacattag caaacgcctt tctgacgctt ctgtttctaa agtagaaatt 138601 gagcgtgcag caaaccgcgt taacattacg atccacacag ctaagcctgg tatggttatc 138661 ggtaaaggcg gttctgaagt cgaagcactt cgcaaagccc ttaacagcct tactggcaag 138721 cgtgtacaca ttaacattct tgaaatcaaa agagcagatc ttgatgcaca gctagttgct 138781 gacaacatcg ctcgtcaatt agaaaaccgt gtttctttcc gccgtgcgca gaaacaacaa 138841 atccaacgta ctatgcgtgc tggagcacaa ggtgtgaaaa caatggtttc tggtcgtctt 138901 ggcggtgcag atatcgctcg ttctgaatac tacagtgaag gaactgttcc attgcacaca 138961 ttacgtgcgg acattgacta tgcaacatct gaagctgata ctacttacgg taagcttggt 139021 gtaaaagtct ggatctatcg tggagaggtt cttcctacta agaagaaaaa tgaggaagga 139081 ggaaaataat atgttattac caaaacgcgt taaatatcgc agagagcatc gcggaaaaat 139141 gcgtggccgt gcgaaaggcg gtactgaagt acatttcgga gaattcggta tccaagctct 139201 agaagcttct tggattacta accgtcaaat cgaagctgca cgtattgcga tgactcgtta 139261 catgaaacgt ggcggtaaag tttggatcaa aattttccct tctaaacctt acactgctaa 139321 accacttgag gtacgtatgg gatccggtaa aggggctcca gaaggttggg tagctgttgt 139381 aaaaccgggc aaagttttat ttgaaatttc tggtgtgtct gaagaggttg ctcgtgaagc 139441 gcttcgcctt gcatctcaca aattgccaat taaaacgaag ttcgtaaaac gtgaagaaat 139501 tggtggtgaa tcaaatgaaa gctaatgaaa ttcgtgacct taccactgct gaaattgaac 139561 aaaaagtaaa gtctcttaaa gaagaacttt tcaatcttcg ctttcaatta gcgacaggac 139621 aacttgaaaa tactgctcgc attcgtgaag tgcgcaaagc tatcgcgcgc atgaaaactg 139681 tgattcgtga aagagaaatt gctgctaata aataatcact gaggggaggt cgtgagcatg 139741 agcgaacgta accaacgcaa agtttaccaa ggccgtgttg tttctgacaa aatggataaa 139801 accattactg ttgttgttga gacatacaaa aaacatacac tttacggtaa acgcgtaaaa 139861 tactcaaaaa aattcaaagc acatgatgaa aataatcaag ctaaaatcgg tgacatcgtt 139921 aagatcatgg aaactcgtcc attgtctgca actaagcgtt tccgtctagt tgaagttgtc 139981 gaagaagctg ttattatcta ataaagttcg gaattctttt tccgaaggga ggtaacaaat 140041 aatgattcaa caagagactc gtttaaaagt agctgacaac tctggcgcac gtgaagtact 140101 tactattaaa gttcttggtg gttctggacg taaaacagct aacattggtg atgtaattgt 140161 ttgcacggtt aaacaagcaa caccaggagg cgttgtcaaa aaaggtgaag tcgtaaaagc 140221 tgttatcgtt cgcactaaaa gcggagcgcg cagaagtgac ggttcataca tcagcttcga 140281 tgagaatgca tgtgttatca tccgtgacga caagagccca cgcggaactc gtatcttcgg 140341 accagttgct cgtgaattgc gtgaaaacaa ctttatgaaa attgtttctc tagctccaga 140401 agttatctaa ttgaaataaa tgccttactc aaggaggtgc gatcaggatg catgtaaaaa 140461 aaggcgataa agttatggtt atctctggta aagataaagg caaacaagga acaatccttg 140521 ctgctttccc taaaaaggac cgcgttttag ttgaaggtgt taacatggta aagaaacact 140581 ctaaaccaac tcaagctaac cctcaaggcg gtatttctaa tcaagaggcg ccaattcatg 140641 tatcaaacgt tatgccgctc gatcctaaaa caggtgaagt gactcgcgta ggatacaaag 140701 tggaagatgg caaaaaagtt cgtgtagcaa aaaaatctgg gcaagttcta gataaatagt 140761 attaaaagga agggaggtct atctcatgaa ccgccttaaa gaaaagtaca ataaagaaat 140821 tgcacctgct ttaatgacta agttcaacta tgattcagtc atgcaagtgc ctaaaatcga 140881 aaaaatcgta atcaacatgg gtgttggtga cgctgttcaa aacgccaaag caatcgacag 140941 tgctgttgag gaattaacgt ttatcgcagg tcaaaaacct gtcgttactc gtgcgaagaa 141001 atcaattgct ggattccgtc ttcgtgaggg aatgcctatc ggtgcgaaag taactcttcg 141061 cggagagcgc atgtatgatt tccttgataa acttatttct gtatctttac cgcgtgtacg 141121 tgacttccgc ggggtttcta aaaaatcttt cgacggtcgc ggtaactaca cacttggtat 141181 caaagaacag ttaatcttcc ctgaaattga ctacgataaa gtaacaaagg ttcgcggaat 141241 ggacatcgtt atcgtaacaa ctgctaatac tgacgaagaa gctcgtgagc tattaactca 141301 agtaggtatg ccgttccaga aataatcaat gaaagggagg cgaaatcgtg gctaaaaagt 141361 ctatgattgc gaaacaacaa cgtacaccaa agtttaaagt acaagagtac acacgctgtg 141421 aacgctgcgg acgtccgcat tcagtcattc gtaaatttaa actttgccgt atttgtttcc 141481 gtgagcttgc atataaagga caaattcctg gcgtgaaaaa agccagctgg taatccccaa 141541 gaaagggaag gaggtaatta tataatggtt atgacagatc caattgcaga tatgctaact 141601 cgtattcgca atgcaaacat ggtacgtcat gagaagcttg aaattcctgc ttctaaattg 141661 aaaagagaaa ttgctgaaat tttaaagcgt gaaggtttca ttcgtgacgt tgagttcgta 141721 gaagacagca aacaaggtat tatccgcgtt ttcttgaaat acggacaaaa caacgagcgc 141781 gttatcactg gtcttaaaag aatcagcaag cctggtttgc gtgtttatgc taaatctaat 141841 gaagtacccc gcgtacttaa cggtcttgga atcgcgatta tttctacatc acaaggtgtt 141901 ttaacggaca aagaagcccg tgcaaaacaa gctggtggag aagttctagc atacgtttgg 141961 taagaagttt aacatgaatg gaggtgtttg gtatgtctcg tgtaggtaag aagctacttg 142021 agattccttc tgatgttaca gtaacgttaa atgataacaa cactgtagct gtgaaaggac 142081 caaaaggaga attaactcgt acgtttcacc ctgatatgga gattaaagta gaggacaatg 142141 tgcttacagt cgctcgtcct tctgatcaaa aagagcaccg tgccctgcat ggtacgactc 142201 gcagtctgct tggcaacatg gttgaaggtg tatctaaagg atttgaaaga ggtttggaat 142261 tagtcggtgt cggttaccgt gcttctaaat ccggaaataa acttgtttta aacgttggat 142321 actctcatcc tgttgagatc gttcctgaag aaggcatcga aatcgaagtt ccttctcaaa 142381 caaaagtagt tgtaaaaggt acagacaaag aacgcgtagg agctattgct gctaacatcc 142441 gcgctgtacg ttctccagag ccttacaaag gtaaaggaat ccgctacgaa ggtgaagttg 142501 ttcgccgtaa agaaggtaaa tctgctaagt aagatcgctt aaagtgaaga aaggagtgac 142561 ctagatgatt acgaaaacta gcaaaaatgc tgctcgtctt aaaagacacg ctcgtgttcg 142621 cgctaaactt tccggtactg ctgaaagacc gcgcctgaac gttttccgtt ctaacaagca 142681 catttacgct caaatcatcg atgatgtaaa tggtgtaaca cttgctagtg catctactct 142741 cgataaagac ttgaacgttg aaagcactgg agatacttct gctgctacta aagttggaga 142801 attagttgca aaacgcgctg ctgaaaaagg catttctgac gtagtatttg accgtggcgg 142861 atacttatac catggacgtg taaaagcttt ggctgatgcc gctcgtgaag ctggacttaa 142921 attttaataa aagaaggagg gacacatgat tatgcgtcgt attgacccaa gcaaattaga 142981 gttagaagaa cgcttagtta cggttaaccg cgtagcgaaa gttgttaaag gtggtcgtcg 143041 tttccgcttc gcagctctag tcgttgtcgg tgacaaaaac ggacacgtag gattcggtac 143101 tggtaaagca caagaagtac cagaagcgat tcgcaaagct gttgaagatg cgaaaaagaa 143161 tttgattgaa gtaccaatgg ttggaactac aattccacac gaaatcatcg gacgtttcgg 143221 tgcaggtaac atcttgttaa aacctgcttc tgaaggtact ggagttatcg ctggaggccc 143281 tgtacgtgcg gtacttgagc tagctggtgt agctgatatc ctttctaagt ctttaggttc 143341 taacacaccg atcaacatga ttcgtgcaac acttcaaggt ttaagtgaac ttaaacgtgc 143401 tgaagacgtt gcgaagcttc gtggaaaatc tgtagaagaa ctgttaggat aaggagggaa 143461 cattaatggc taaattagaa attaccctca aacgaagtgt aatcggtcgc ccggaagacc 143521 aacgcgttac tgtaagaaca cttggtttaa agaaaacaaa ccaaactgtt gttcatgaag 143581 acaacgctgc gatccgtggt atgattaata aagtatctca tttagtttct gttaaagaac 143641 aataaaaata tttgatcgga taaggaggtg tcctaatgaa acttcatgaa ttaaaacctt 143701 cagaaggttc acgcaaaacg cgtaatcgcg taggtcgtgg tattggttct ggcaacggta 143761 aaacagctgg taaaggtcac aaaggtcaaa acgctcgttc tggcggcggt gtacgccctg 143821 gattcgaggg gggacaaatg cctttattcc aacgtcttcc taaacgtggt ttcactaaca 143881 tcaaccgcaa ggaatacgct gtagtcaacc tagacaaatt gaacggtttt gcagaaggaa 143941 cggaagtcac tcctgaactt cttctagaga ctggtgttat tagcaaactt aatgcaggag 144001 taaagattct tggcaacggt aaattagaga aaaaattaac tgtaaaagcc aataaattct 144061 ctgcttctgc gaaagaagct gttgaagctg ctggcggtac agctgaggtg atctaacttg 144121 tttaaaacaa tctccaactt tatgcgtgtg agtgatatca ggaataaaat catattcact 144181 ttactcatgc ttatcgtctt tcgcataggt gcgtttattc ctgtgcctta cgttaacgct 144241 gaagcgttac aggcacagtc tcaaatgggt gtttttgatc tccttaatac atttggcggc 144301 ggtgcgcttt accaattttc cattttcgca atgggaatta ctccttatat cacggcttcg 144361 atcatcattc agctgcttca gatggatgtg gtaccgaagt ttaccgagtg gtctaagcaa 144421 ggtgaagttg gccgccgtaa attagctcag ttcacaaggt actttacgat tgtgcttggt 144481 ttcatccaag cgttaggtat gtcatatgga ttcaacaatc tggcaaacgg tatgctgatc 144541 gaaaaatccg gtgtatcgac atatcttatc attgctttag tgctcactgg cggaactgcc 144601 tttttaatgt ggcttgggga acaaattact tctcatggag taggcaacgg aatatcgatc 144661 attatcttcg cggggattgt gtctagtatt ccaaaaacaa ttgggcaaat atatgagact 144721 caatttgtcg gcagcaacga tcagttgttt attcatattg tgaaagtcgc acttcttgtg 144781 attgcgattt tagcagttat tgttggagtt attttcattc agcaagccgt acggaaaatt 144841 gcgattcaat atgctaaagg cacaggtcgt tcacctgctg gcggaggtca gtctacacac 144901 cttccattga aagtgaatcc tgcaggggtt attccggtaa tctttgcggt tgcgtttttg 144961 ataacgccgc ggacgatcgc gtcattcttt ggaacaaacg atgtgacaaa gtggattcaa 145021 aacaactttg ataatacgca tccggtgggt atggcgatat atgttgcgtt gattattgcc 145081 tttacgtact tttatgcttt tgtacaggta aaccctgaac aaatggctga taaccttaaa 145141 aaacagggtg gctatatccc gggggttcgt ccagggaaaa tgactcaaga tagaattacg 145201 agcattttgt atcgacttac gtttgtgggt tctatattct tagccgtgat ttccattctt 145261 cctatctttt tcattcaatt cgctggattg cctcaaagtg cacaaattgg cggaacatct 145321 ttgttaattg ttgtcggggt agccttggag acaatgaaac aactagaaag ccagttggtg 145381 aaacgaaact accgtggatt tatgaaaaac tagaggaaat ggatttatcc attccctctt 145441 aataaagaga ggacggggga aatccgaatg aacttagtct taatggggct tcctggtgcc 145501 ggtaaaggca cacagggcga acgaattgtt gaggattatg ggattcctca tatctcaaca 145561 ggagatatgt tccgtgctgc tatgaaagaa gaaacaccac tcggactcga agcaaaatct 145621 tatattgata agggagagct cgtacctgac gaagtcacaa tcggaattgt aaaagagaga 145681 cttggcaaag atgattgtga aagaggtttt cttctggacg gatttccgcg aacagtcgct 145741 caagccgaag ctcttgaaga aattcttgag gaatacggca agccgattga ttatgtcatt 145801 aacattgaag tcgacaaaga tgttctgatg gaacgtctga ctggacgcag aatttgcagt 145861 gtttgcggca caacctatca tttagtcttt aatccgccga aaacgccggg tatttgtgat 145921 aaagacggag gcgaactcta tcaacgggca gatgataatg aggaaacagt ctctaaacgg 145981 cttgaggtaa acatgaagca aactcagcct ttactcgatt tctattcaga gaaaggttat 146041 cttgcaaacg tgaatggcca gcaggacatt caagacgttt atgcagatgt gaaggatctt 146101 cttggaggat taaaaaaatg attatctgta aaaccccacg tgaacttggt atcatgcggg 146161 aagcagggcg aatcgtggct ttaactcatg aagagttaaa aaagcacatt aaaccaggaa 146221 tctcgacaaa agaattggat caaattgccg aacgttttat taagaagcag ggtgcaatcc 146281 catcttttaa ggggtataat gggtttcgcg ggagcatttg cgtatcagtt aatgaagaac 146341 tcgttcacgg catacctggc agcagggtgc tgaaggacgg tgacatcatc agtattgata 146401 tcggtgctaa attaaatggt tatcatggtg actctgcatg gacatatccg gtaggaaaca 146461 tcagcgatga tgacaaaaaa cttctggaag tgacagagga gtctttatat aaaggcttgc 146521 aggaagcaaa accaggtgaa cgtttgtcga atatttccca cgcaatacaa acgtatgtcg 146581 aaaatgagca gttttcagtt gttagggagt atgtcggaca tggtgttggt caagacttgc 146641 atgaggaccc gcaaattcct cattacggtc cgcccaacaa aggaccacgg cttaaacctg 146701 gcatggttct cgctattgaa cctatggtga acgctggcag ccgctacgtg aaaacattgg 146761 ctgataactg gacggttgta acggtagatg ggaaaaagtg tgctcatttt gaacatacga 146821 ttgcgattac ggaaacgggt tttgatatac tgacgagagt ctagatgatg aaaataattc 146881 cgaagacaga tgtttttcaa gcttgatagg gcagaaagct tgggtgaaca ttggcaagac 146941 cgaattcatc ttgcttcttg tcgttggaat tttaaccatc atcaatgtac taacagcaga 147001 cggagaaaag cgtacatttc attctcctaa gaaaaagaat atcaatcatt taacccttta 147061 tgattgcgta tctccggaag ttcagaacag tataaacgaa acagggcgtg tgacaaactt 147121 cttttgaaat ttgtcagaaa gcaagttact gatttgaaga agggagaaca cttgaatggc 147181 gaaagacgat gtaattgaag tggaaggtac tatagtcgaa acactgccaa acgcgatgtt 147241 caaagttgaa cttgaaaatg gccacactgt tttggctcat gtatctggta aaatccgcat 147301 gcacttcatt cgcattttac ctggagacaa agttacggta gaattatctc catatgactt 147361 aactcgtggc aggattacgt accgttacaa ataaagcact ccggaaactg aaggaggttg 147421 gaaacacatg aaagtgagac catcagttaa accaatctgc gaaaaatgta aagttattcg 147481 cagaaaagga aaagtaatgg tgatctgtga aaatccaaag cataaacaaa aacaaggata 147541 atttataagg aggtgcccag agaatggctc gtattgctgg tgtagatatc ccacgtgaca 147601 aacgtgttgt tatttcttta acatacatct tcggaattgg ccgcacaacg gctcagcaag 147661 ttttaaaaga agctggagtt tcagaagata ctcgtgtgcg cgatcttact gaagaagaac 147721 ttggtaaaat ccgtgatatt attgacaaac tgaaagtaga aggtgacctt cgccgtgaag 147781 tttctcttaa tatcaaacgt ctgatcgaaa tcggaagcta ccgcggaatc cgtcatcgca 147841 gaggattacc tgttcgcgga caaaactcta aaaacaacgc gcgtactcgt aaaggtccgc 147901 gtcgtactgt agctaacaag aaaaaataag taagggaggt tcttaaacaa tggctgctgc 147961 tcgtaaatct aacacgcgta aacgtcgcgt gaaaaagaat attgagtctg gaattgctca 148021 tattcgttca actttcaata acacgatcgt tacgatcact gacactcatg gtaatgctat 148081 ttcttggtct agtgccggag ctttaggatt cagaggttct cgtaaatcta ctccttttgc 148141 tgcgcaaatg gctgcagaaa cagctgctaa aggttcaatc gaacatggtc ttaaaactct 148201 agaggttact gttaaaggac ctggttcagg ccgtgaagct gcaatccgtg cacttcaagc 148261 tgctggacta gaagtcactg ctatcagaga cgtaactcct gttcctcata acggatgccg 148321 tccaccaaaa cgtcgccgcg tgtaatttgt ttgtatagat tttgtgtccc tgtcaataat 148381 gggttatgat acagttattt atgaaacgaa tgcaccgact cgttgcctga gcacatacgg 148441 gactaaacaa tggggaattt cggatggaat ctcatatgat tctattcgag gtttcgacgt 148501 tttgaaggag ggttttaagt aatgatcgag attgaaaaac caaaaatcga aacggttgaa 148561 atcagcgacg atgccaaatt tggtaagttt gtcgtagagc cacttgagcg tggatatggt 148621 acaactctgg gtaactcctt acgtcgtatc ctcttatcct cactccctgg tgccgctgta 148681 acatcaatcc agatagatgg tgtactgcac gaattctcga caattgaagg cgttgtggaa 148741 gatgttacaa cgattatctt acacattaaa aagcttgcat tgaaaatcta ctctgatgaa 148801 gagaagacgc tagaaattga tgtacagggt gaaggaactg taacggcagc tgatattaca 148861 cacgatagtg atgtagagat cttaaatcct gatcttcata tcgcgactct tggtgagaat 148921 gcgagtttcc gagttcgcct tactgctcaa agaggacgtg ggtatacgcc tgctgacgca 148981 aacaagagag acgatcagcc aatcggcgtg attccgatcg attctatcta tacgccagtt 149041 tctcgtgtat cttatcaggt agagaacact cgtgtaggcc aagttgcaaa ctatgataaa 149101 cttacacttg atgtttggac tgatggaagc actggaccga aagaagcaat tgcgcttggt 149161 tcaaagattt taactgaaca ccttaatata ttcgttggtt taactgacga agctcaacat 149221 gctgaaatca tggttgaaaa agaagaagat caaaaagaga aagttcttga aatgacaatt 149281 gaagaattgg atctttctgt tcgttcttac aactgcttaa agcgtgcggg tattaacacg 149341 gttcaagagc ttgcgaacaa gacggaagaa gatatgatga aagttcgaaa tctaggacgc 149401 aaatcacttg aagaagtgaa agcgaaacta gaagaacttg gactcggact tcgcaaagac 149461 gattgactag tttcccttgt gaactaggat tttcgtgtgt ttattattca gaaacagcat 149521 tccaataaag gaggggacat cacatgtcat acagaaaact aggacgtacg agtgcacagc 149581 gtaaagctat gcttcgtgat cttacaactg atttgatcat caacgaaaga atcgaaacaa 149641 ctgaaacacg tgcgaaagaa cttcgctctg tagttgaaaa aatgatcacg cttggcaaac 149701 gcggtgatct tcacgctcgc cgtcaagctg ctgcatacat ccgcaacgag gttgcaaacg 149761 aagaaaataa tcaagatgca cttcaaaaat tattctctga cattgcaact cgttacgagg 149821 agcgccaagg tggatacaca cgtattatga agcttggtcc tcgccgtggt gacggagcac 149881 caatggcaat tatcgaattg gtttaatcac atatttttgt gtatctaaag aagggcggga 149941 cagtttctaa ctggatctat gccctttttt tagatactgc aacttttaat agagagaaaa 150001 gcagagcatt agctgagagg aggccggttt tccatgaatc aaaatcagtt gatatcggta 150061 gaggatatcg tatttcgata tcggaaggac gcagaaagac gagcactaga cggcgtctcc 150121 ctgcaggtgt atgagggtga atggcttgca atcgtaggtc ataacggttc agggaaatca 150181 acactggccc gggcattgaa tggtttaatt cttcctgaat caggcgacat tgaggttgcc 150241 gggattcaat tgacagagga atctgtttgg gaagtgcgta agaagatagg tatggtcttt 150301 caaaatccgg ataaccaatt tgtcggaacg actgttcgcg atgatgtggc ttttggttta 150361 gaaaacaatg gtgtaccgcg ggaagaaatg attgagagag tagactgggc agtaaaacag 150421 gtgaatatgc aagattttct cgatcaagag ccgcaccatc tctccggagg ccaaaagcag 150481 agagttgcga ttgcgggggt tattgccgca cgtcctgata ttattatctt agatgaagca 150541 acatccatgc ttgatccgat cgggcgagaa gaagtgcttg aaacggtaag acatttaaaa 150601 gagcagggca tggcgactgt catatccatt acacatgacc tgaatgaggc agcaaaagca 150661 gacaggatca ttgtcatgaa tggcggtaaa aaatatgctg aagggccgcc tgaagagatt 150721 tttaaattga ataaagaact tgttcgaatt gggcttgatt tacccttctc attccagctt 150781 agccagcttt taagagaaaa tggactggct ttggaagaaa accatttgac tcaggaaggg 150841 ctggtgaaag agctgtggac attacaatca aagatgtaga gcatcgctat cagatgaaga 150901 ccccgtttga gcgcctagca ctgtatgata tcaatgcatc gattaaagaa ggaagctacg 150961 tagccgttat cgggcataca ggctctggca agtccactct tctacagcac ctaaatggtc 151021 tcctgaagcc gacgaaggga cagatatcac taggcagcac tgtcattcag gcagggaaaa 151081 agaataaaga tctgaaaaaa cttcgtaaaa aagtcggaat cgttttccaa tttcctgagc 151141 atcaattatt cgaagaaaca gttcttaaag atatttcatt cggaccgatg aactttggtg 151201 ttaaaaaaga agatgctgaa caaaaagcga gagagatgct gcagcttgta ggtttatcag 151261 aagagctttt ggacaggtca ccctttgaat taagcggggg acaaatgcgc agagttgcaa 151321 ttgccggcgt acttgcaatg gaccctgaag tgcttgttct ggatgaaccg actgcaggat 151381 tggacccaag agggcgaaaa gagattatgg acatgtttta tgagcttcat caacgtggga 151441 acttgacgac gatccttgtg acacacagca tggaggatgc agctgcatac gctgatgaaa 151501 tgattgttat gcataaagga acgatacaag catcaggcag tccgcgtgat ctgtttttaa 151561 agggtgaaga gatggccggc tgggggctgg atcttcctga aacaataaaa ttccaaagac 151621 accttgaagc tgcactgggt gtgagattta atgagcctat gctcacaatc gaagatgccg 151681 ctgccgaaat ccgtgctctt tttcagggag agaagacttt atgatggaca gcatgattat 151741 cggcaagtat gtaccgggga cttcacttgt gcaccggctt gaccccagaa caaaactgat 151801 cacgatcttt ttatttgtct gcattgtatt cttagccaat aatgttcaga catatgcgtt 151861 gcttggttta tttacaattg gcgtcgtttc tttaacaaga gttcctttct cttttttaat 151921 gaaagggctg aagccaatca tctggattgt cctttttacg ttccttcttc acattcttat 151981 gacacatgaa ggaccgatta tctttcaaat aggttttttc aaagtctatg agggcggtct 152041 ggttcagggg atattcattt ctcttagatt cgtctatttg attttaatca caaccttatt 152101 aacgcttacg actacaccga ttgagattac cgatggaatg gagcagctgc tgaacccatt 152161 gaaaaaatta aagcttcctg ttcatgagct ggctcttatg atgtcaattt ctttacggtt 152221 tattccgaca ctgatggagg agacagataa gatcatgaag gctcagatgg cgcgaggcgt 152281 tgattttaca agcgggcctg tcaaagaaag agtgaaggct attgtcccgc ttcttgtccc 152341 gctcttcgtc agcgcattta aacgcgccga agagcttgcg gtggcaatgg aagcaagagg 152401 ctatcaaggc ggagaaggac gtacgaaata tagaaagctt gtatggacag gaaaagacac 152461 ttctgtcatt gtcagcttaa ttgtattagc tgctttgtta tttttcttaa gggcttagag 152521 gtgctgtatg agactgaaat gcacgatttc ttatgacgga catttgttta acggttatca 152581 ggttcagccg ggcaaaagaa cggttcagga tgaactggag aaggctttgg ctgtcctgca 152641 taagtcaaaa gacagaattc cggtcgtttc gtctggaaga acagacagcg gggttcacgc 152701 agccggacag gtgattcatt ttgacactcc gctgtctatc ccggctgaga gatggccata 152761 tgccttaaat gcactgcttc cggacgatat cgcagtcaaa caggcagaaa ttgcggatga 152821 tgggttccat gcacgattta gcgcagtcaa aaaagaatat cgctactttg tatacacgga 152881 gaaacacccg gacgtattta aacggcatta cgcttaccat ttttcatatc gccttaatgt 152941 gcaggacatg agagaagcgg caaagcatct tatagggaca catgatttta cgagcttttg 153001 cgcggctaaa acagaagtgc aggacaaggt aagaacgata tacgaacttg attggactga 153061 gacggctgac ggcctgcaaa tgcggatcac aggcagcggt ttcttatata atatggtcag 153121 aattattgcg ggtactttgc ttgatgcagg tattggaaaa atttctcccg atgaggtgaa 153181 atccatgctg gaagcgaagg atcgcgaagc ggcagggcgc acagcgccgg ggcacgggct 153241 atatttatgg aacgtttact atgacaacta aaccaggtgt ataatatttt cttgacagag 153301 tctgcataaa gttataagat atcatatggt atgtatttca accccacgat aagccccgga 153361 acttattgtg ttgtgaaata gaacgtaatc gaagtttatt gaaaatgaca gatcatttag 153421 gagggaaatt caatgcgtac aacacctatg gctaacgcaa gtactattga acgcaagtgg 153481 ttagttgttg atgctgctgg caagacttta ggtcgtcttt cttcagaagt tgcagctatc 153541 cttcgcggaa aacacaaacc aacttacaca ccacacgttg atactggaga tcatgtgatc 153601 atcatcaacg ctgaaaaaat cgagttaact ggtaaaaagt taactgacaa aatctactac 153661 cgtcacactc aacatccagg cggattaaaa tcaagaactg ctcttgaaat gcgtacaaac 153721 taccctgaga aaatgcttga gcttgctatc aaaggcatgc ttccaaaagg ttctctaggt 153781 cgtcaaatgt tcaaaaaatt gaacgtatac cgtggttctg agcatccaca cgaagcacaa 153841 aaacctgaag tttacgaact tcgcggttaa ttaaaaagga ggttaccaat ttggcacagg 153901 ttcaatatta cggtactggc cgtcgtaaaa gctctgtagc gcgtgtgcgt ttagttccag 153961 gagaaggccg tatcgtcgtt aataatcgtg aaatcagcga acatatccca tctgcagctt 154021 taatcgaaga tatcaaacaa ccattaactt tgactgaaac agctggcact tatgatgttt 154081 tagtaaacgt acatggaggc ggcctatctg gtcaagctgg agcaatccgt cacggtatcg 154141 ctcgtgcttt gcttgaagca gatccagaat accgtacaac tcttaaacgt gcaggtcttc 154201 tgactcgtga cgctcgtatg aaagaacgta aaaaatacgg tcttaaaggc gctcgtcgtg 154261 cacctcagtt ctcaaaacgt taattttacg ttttcaaaaa gctctcgacc ttgggttggg 154321 agcttttttc tttcaataaa acgtggcagt cccgcataaa aataacaact gaatggacgc 154381 ttgacggggt taagcaaatt gtttgtttat aaacggtctc tttgtaataa tcatggtaga 154441 tttcattctt attcaattgg aagttcggtc aatgtttatt atcgttatgt gatcagccca 154501 gctccatcta accactgtat ctcatccgtt aaagttcact gctgattctt aacccggaga 154561 aacaatagct ctcattgcta atggctttat gtaacgaagt aaaagtaaat ctgatgatat 154621 aaatcacata tctcctttgt gatttttttg cgtttttatg aacttttttc taaatatgca 154681 aagggaaagc gatatcaatc tagaaatatt tgttatactc tatacattaa agtaaggaga 154741 agattcatga atgcgttagt agctcataat agcaaagcct gggataaaaa agtagaaaca 154801 ggcaatgaat ggactgttgc tgttgaacag caggttatcg aacaagcaaa aaaaggcaat 154861 tgggatataa gggtaacacc aatgaaagat gtaccgaagg attggtttcc gcctatcaaa 154921 ggtctgaaag tactctgttt agcatcaggc ggcggccagc agggtccagt tttggcagcc 154981 gcaggcgcgg atgtcactgt attagataac tcagaaaaac agctgaatca ggatagaatg 155041 attgctgagc gagatggtct gacgatacac actgtcaaag gaagcatgga cgatttaagt 155101 gtatttaatg atgaatcatt tgatgtcatt gtacatcctg ttgccaatgt ttttgttgag 155161 aatgtcctcc cggtatggaa ggaagcgtac cgtgtgttga aaaggaacgg cattctaatc 155221 tcgggttttg tcaatcctgt tgtatttctg tttgatacag aattagaaca gcaaggtgtt 155281 ttaaaagtaa aacactctat tccatacgct gacccagaag atcttccgaa acataaagtg 155341 aaaaaactga tcgaaaataa tgaggctctg gaattcggcc attccttaga agaccaaatc 155401 aaaggccaaa ttgatgccgg ttttatcgtt actggttttt atgaagataa aggcggtttt 155461 gtattagacc aatatatcca tacatattct gcaacaagaa gcgtgaaagt atgaaaagca 155521 gcgacctgtt agaggggctg cttttttcat aaccaattac agaacatttg ttcctcaccc 155581 tgcagaaagc tgatttttta tcaatgttac accttcattt gggcgaattt ccaaccgaat 155641 tcgggcattg tttcatcatc caaacctcaa aataatcggt aaaaggagag tgaatttata 155701 tggcagaagt actgtctttt atggatgtga aacgccaaaa ggattttgaa ttagaaaaga 155761 acttgctcaa agaactctct ctgagacaaa ttatccagtc tgttaaggat tgtttggaac 155821 cattatttcc atttttacat gatgaacgag atattattac cgaaggctgt attgattttg 155881 cgattgaagc ttatttgtta ggcgggcgtt ttgggatatt cggctattac ggagaatcaa 155941 tgcagagtat cagtgcccgc tctgcaagag aagaagaaga gctgcgtatg gagttttttg 156001 attatctcta taattggata cacgagcaat acgcaacatt tgataaaaac actgtttatg 156061 aagcggcacg caagttcatt aaagattggt ggacagcagg gtttgttcaa agagaaaaac 156121 agtgtaagct tcgcatgcgg taatcatatt tcccgaccct gtcccatagt tatgtaataa 156181 cggacaagcg ggaggggaag ggatgaggaa aaagcttaaa tggctcagtt ttttgctagg 156241 cttcatcata ttactatttc tgttcaagta tcagttcagc aataacgact cttggaagcc 156301 gtggagcctg cccttgagcg gtaaaatcat ttatctagat ccaggtcatg gcgggcctga 156361 cggcggagca gtcggcggaa agctgttaga gaaggatgtt accctggaag tggcctttag 156421 agtcagggat tatcttcaag aacaaggagc gcttgttatc atgaccagag aaagtgatac 156481 tgatctcgct ccagaaggaa caaaaggcta tagccgacga aaagctgagg atctaagaca 156541 acgagtcaaa ttaataaacc attcagaggc ggagctctat atcagcattc atcttaatgc 156601 gattccgtca caaaaatgga gcggagccca aagcttttat tacgggaaat atgcggaaaa 156661 tgagaaagtc gcaaaataca ttcaggatga gctgagaaga aatctggaaa acacaacccg 156721 gaaagcaaag cggattcatg gtatctactt aatgcaaaac gtcaccaaac cgggggcgct 156781 tatagaagtc ggatttttat ccaatccaag tgaagcaacg ttgctcggta aaccgaaata 156841 tcaagacaag gtggcatctt ccatatataa aggcattttg cgatatttca cagaaaaagg 156901 agaccctccg gagtaatgga gggttttctt gtggttctaa gcataagaca cccgccattt 156961 atgtatgata taataataat tgtaaacgaa tacacaaaag ggtgaggttc gatgataaga 157021 gaagatgaag taagaaaact agtcggagaa atgcgcgaac cttttcttca aagacctctg 157081 ggagaattgg atgccgttaa ggaaattaaa ataaagcctg aaaaacggca tatcagtgta 157141 aaagtcgctc ttgcaaaaac aggaactgca gaacaaatgc agattcagca agagatcgta 157201 aacgtattaa aaggggcagg agctgagaca gtcggccttc gatttgaaga gctgcctgaa 157261 gaaacggttg ctaaattccg ggcgccgtca gctgagaaaa aaacattatt aaatatggat 157321 aacccgccag tctttcttgc tgtagcaagt ggaaaaggcg gcgtaggcaa gtcaactgtg 157381 tcagtaaacc tagctatttc tctggctcgt ctagggaaaa aggttggttt aattgatgcg 157441 gatatttatg ggttcagtgt gccggacatg atgggtatca ctgtgcgtcc aacaattgaa 157501 ggagagaaac ttcttcctgt tgaacgcttt ggagtaaagg tcatgtcaat gggctttttc 157561 gtagaagaaa atgccccggt cgtatggaga gggccgatgc tcggcaaaat gctgaataat 157621 tttttccatg aagtagagtg gggagaagta gactatatcg ttcttgatct tccgcctggt 157681 acaggggacg ttgctctcga tgtacataca atgcttccga gctgcaaaga aattatcgta 157741 tctacgccac atccgacagc tgcttttgtc gcggccagag cgggctctat ggcgattaaa 157801 accgatcatg aggtcgtggg tgtcatagag aacatggctt attatgaaag tgcaaagaca 157861 ggggaaagag aatatgtgtt tggaaaaggc ggaggagata aactggctga ggaactaaac 157921 gtgcctttgc tcggcagaat cccattgaaa cagcccgatt gggataagga ccaatttgct 157981 ccgtctgttt atgacgaaaa tcatccaatc ggagaaatat atcaggacat cgcaaaaaaa 158041 atagatgcaa aaatgtcagt gcaggtataa aaggtgaacc gggattccag atcccggctt 158101 tccctttatt cactttcttt tgctgtgtct tttgctgctt ttttcagctc atcttcgaac 158161 tgctttttgt aaagcggact agaaagtgtt tcgttaataa cctcttctaa ataactgcgg 158221 aattcttggc tttttgccag ctggctgtac tttttatcca tgccgggatc ctgcataacg 158281 ctcatcagca tcttctggta atctggatcc ttcatcagct ttttaatcac tttttcatgc 158341 tctgtctgaa gagttttggc aaagccctca gcaaaatcag tgtcttcaaa gatgtttttc 158401 caaaattctt cacctttttt agatgtgagt gttttttcta ttgttccttt aattgcatct 158461 tggtcaatca ccagcgcttc attcatggca tcatcattta ataattcctt aatagctttc 158521 tttccatcat cagtttttaa tatatcaaca accatttttt tggtctgatc atagtccata 158581 tccgctgctt ggtcttttgg agcgcaagct gttacagata ataacaaaaa acagctcatc 158641 aatagcgttt tggcttttga catgcttaag ctcctttcac atacttgtct tacctttaat 158701 atgattcatc tgtttggaat tatacataac aaaatatcgc tgttcgcgat ttttgagggg 158761 atgaataaag aaatgaaaag ccgtggttta gttcgttttt tcttttctat tttagctgtc 158821 ggggcgctta tcacgagtat tgtgggtttt gctttaaagt ggggagaata tagagggctg 158881 tttctaacat ttgaagcggg acagattttc tctgttttat tttggtttat cggtgtaggc 158941 atgattttca gtgtgatcag ccaaatgggt tttttcgtgt ttttaacagt tcatcggttt 159001 gcgcttgaga tattaaggtc ctcctctttg tggaatttgc tgcagttgtt tttcatcctg 159061 tttgttgctt ttgatttaat gtacgtgcgt tttttatttt ttggagagag cggagaatcg 159121 ctggctggct atgcgtggtt accggtgttt ttattgatct ttggagtgat tacagcttat 159181 ataaagcaaa agcagtcctc taagaaaaca tttgtgtcat cgttattttt gatggttgtg 159241 attaccgcat tagaatggtt ccctgcatta agagtaaatg atgaggactg gctttattta 159301 atgctttttc cgttaatggc atgtaatgcc ttccaattgc tgatgctgcc gaagtttgca 159361 gcaaagtaat tactttacct ctgcggattt ggcatcagaa tttgcgatga gatcacccac 159421 ggttacattt tttaatcctt tttctttcag ctgatggatg atatcaggca atgcttcttc 159481 tgtttgtttt gcagaatcgg aggcatgtaa aagaataatg tctccaccgg aaacttgctt 159541 ggtcacattg tcgatgattt tttcaactcc gggatttgtc cagtcttgag agttcacact 159601 gtaatgaacg actgtataat tgtattgctt tgcgaccttt agaacattct tattgaattg 159661 gccggtaggg ggtcttaata gctgtatgtc tttgacccct aacttttcaa aggctgtttg 159721 cgcacggttc atgtcctttt ttatttcgct gctctctaaa ttggcatagt ttttataagc 159781 gtagcccatg ctcccgattt gatggccgtc ctttacgata cgggccactg tgtcgggatg 159841 gcgttctgcc caagaagcgg acaggaaaaa cgttgcgttt ttaatcccgt ttgctttcag 159901 agtattaagt atcggttctg ctctctcatc accccagctg atatcgaaag taagtgaaat 159961 atctttagag tctgtttctc ctttataaat ggctttaggt ccggtgtcag ttgaaaacac 160021 gggaagcggg acagctcttt ggatataaaa aaagctggca gctgcaaatg cggcgataag 160081 tataataatt aattgtttta cccgtttaat gtgccacaca tagaagtgat tcactgatga 160141 tgcctcctta tcttgtccat cattcttgtt ttacatctta tgagcatgga caattgaata 160201 taaccgataa aatgtctctt cacatacagc ctaaattggg tgttgacctt ttgataatat 160261 ccgtgatata ttattattcg tcgctgataa acagctgaca tcaactaaaa gcttcattaa 160321 atactttgaa aaaagttgtt gacttaaaag aagctaaatg ttatagtaat aaagctgctt 160381 cgttaagcgg cagtaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca 160441 tttttataaa tcgcacagcg atgtgcgtag tcagtcaaac tactttatcg gagagtttga 160501 tcctggctca ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag cggacagatg 160561 ggagcttgct ccctgatgtt agcggcggac gggtgagtaa cacgtgggta acctgcctgt 160621 aagactggga taactccggg aaaccggggc taataccgga tggttgtttg aaccgcatgg 160681 ttcaaacata aaaggtggct tcggctacca cttacagatg gacccgcggc gcattagcta 160741 gttggtgagg taatggctca ccaaggcaac gatgcgtagc cgacctgaga gggtgatcgg 160801 ccacactggg actgagacac ggcccagact cctacgggag gcagcagtag ggaatcttcc 160861 gcaatggacg aaagtctgac ggagcaacgc cgcgtgagtg atgaaggttt tcggatcgta 160921 aagctctgtt gttagggaag aacaagtacc gttcgaatag ggcggtacct tgacggtacc 160981 taaccagaaa gccacggcta actacgtgcc agcagccgcg gtaatacgta ggtggcaagc 161041 gttgtccgga attattgggc gtaaagggct cgcaggcggt ttcttaagtc tgatgtgaaa 161101 gcccccggct caaccgggga gggtcattgg aaactgggga acttgagtgc agaagaggag 161161 agtggaattc cacgtgtagc ggtgaaatgc gtagagatgt ggaggaacac cagtggcgaa 161221 ggcgactctc tggtctgtaa ctgacgctga ggagcgaaag cgtggggagc gaacaggatt 161281 agataccctg gtagtccacg ccgtaaacga tgagtgctaa gtgttagggg gtttccgccc 161341 cttagtgctg cagctaacgc attaagcact ccgcctgggg agtacggtcg caagactgaa 161401 actcaaagga attgacgggg gcccgcacaa gcggtggagc atgtggttta attcgaagca 161461 acgcgaagaa ccttaccagg tcttgacatc ctctgacaat cctagagata ggacgtcccc 161521 ttcgggggca gagtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg 161581 gttaagtccc gcaacgagcg caacccttga tcttagttgc cagcattcag ttgggcactc 161641 taaggtgact gccggtgaca aaccggagga aggtggggat gacgtcaaat catcatgccc 161701 cttatgacct gggctacaca cgtgctacaa tggacagaac aaagggcagc gaaaccgcga 161761 ggttaagcca atcccacaaa tctgttctca gttcggatcg cagtctgcaa ctcgactgcg 161821 tgaagctgga atcgctagta atcgcggatc agcatgccgc ggtgaatacg ttcccgggcc 161881 ttgtacacac cgcccgtcac accacgagag tttgtaacac ccgaagtcgg tgaggtaacc 161941 ttttaggagc cagccgccga aggtgggaca gatgattggg gtgaagtcgt aacaaggtag 162001 ccgtatcgga aggtgcggct ggatcacctc ctttctaagg atattatacg gaatataaga 162061 ccttgggtct tataaacaga acgttccctg tcttgtttag ttttgaagga tcattccttc 162121 gaaacgtgtt ctttgaaaac tagataacag tagacatcac attcaagtaa tacaagatat 162181 cacatagtga ttctttttaa cggttaagtt agaaagggcg cacggtggat gccttggcac 162241 taggagccga tgaaggacgg gacgaacacc gatatgcttc ggggagctgt aagcaagctt 162301 tgatccggag atttccgaat ggggaaaccc accactcgta atggagtggt atccatatct 162361 gaattcatag gatatgagaa ggcagacccg gggaactgaa acatctaagt acccggagga 162421 agagaaagca aatgcgattc cctgagtagc ggcgagcgaa acgggattag cccaaaccaa 162481 gaggcttgcc tcttggggtt gtaggacact ctgtacggag ttacaaagga acgaggtaga 162541 tgaagaggtc tggaaaggcc cgccatagga ggtaacagcc ctgtagtcaa aacttcgttc 162601 tctcctgagt ggatcctgag tacggcggaa cacgtgaaat tccgtcggaa tccgggagga 162661 ccatctccca aggctaaata ctccctagtg accgatagtg aaccagtacc gtgagggaaa 162721 ggtgaaaagc accccggaag gggagtgaaa gagatcctga aaccgtgtgc ctacaagtag 162781 tcagagcccg ttaacgggtg atggcgtgcc ttttgtagaa tgaaccggcg agttacgatc 162841 tcgtgcaagg ttaagcagaa gatgcggagc cgcagcgaaa gcgagtctga atagggcgca 162901 tgagtacgtg gtcgtagacc cgaaaccagg tgatctaccc atgtccaggg tgaagttcag 162961 gtaacactga atggaggccc gaacccacgc acgttgaaaa gtgcggggat gaggtgtggg 163021 taggggtgaa atgccaatcg aacctggaga tagctggttc tctccgaaat agctttaggg 163081 ctagcctcaa ggtaagagtc ttggaggtag agcactgatt ggactagggg cccctaccgg 163141 gttaccgaat tcagtcaaac tccgaatgcc aatgacttat ccttgggagt cagactgcga 163201 gtgataagat ccgtagtcga aagggaaaca gcccagaccg ccagctaagg tcccaaagta 163261 tacgttaagt ggaaaaggat gtggagttgc ttagacaacc aggatgttgg cttagaagca 163321 gccaccattt aaagagtgcg taatagctca ctggtcgagt gactctgcgc cgaaaatgta 163381 ccggggctaa acgtatcacc gaagctgcgg actgttcttc gaacagtggt aggagagcgt 163441 tctaagggct gtgaagccag accggaagga ctggtggagc gcttagaagt gagaatgccg 163501 gtatgagtag cgaaagaggg gtgagaatcc cctccaccga atgcctaagg tttcctgagg 163561 aaggctcgtc cgctcagggt tagtcgggac ctaagccgag gccgaaaggc gtaggcgatg 163621 gacaacaggt tgatattcct gtaccacctc ctcaccattt gagcaatggg gggacgcagg 163681 aggatagggt aagcgcggta ttggatatcc gcgtccaagc agttaggctg ggaaataggc 163741 aaatccgttt cccataaggc tgagctgtga tggcgagcga aatatagtag cgaagttcct 163801 gattccacac tgccaagaaa agcctctagc gaggtgagag gtgcccgtac cgcaaaccga 163861 cacaggtagg cgaggagaga atcctaaggt gatcgagaga actctcgtta aggaactcgg 163921 caaaatgacc ccgtaacttc gggagaaggg gtgctctgtt agggtgcaag cccgagagag 163981 ccgcagtgaa taggcccagg cgactgttta gcaaaaacac aggtctctgc gaagccgtaa 164041 ggcgaagtat aggggctgac gcctgcccgg tgctggaagg ttaagaggag cgcttagcgt 164101 aagcgaaggt gcgaattgaa gccccagtaa acggcggccg taactataac ggtcctaagg 164161 tagcgaaatt ccttgtcggg taagttccga cccgcacgaa aggcgcaacg atctgggcac 164221 tgtctcaacg agagactcgg tgaaattata gtacctgtga agatgcaggt tacccgcgac 164281 aggacggaaa gaccccgtgg agctttactg cagcctgata ttgaatgttg gtacagcttg 164341 tacaggatag gtaggagcct tggaaaccgg agcgccagct tcggtggagg catcggtggg 164401 atactaccct ggctgtattg accttctaac ccgccgccct tatcgggcgg ggagacagtg 164461 tcaggtgggc agtttgactg gggcggtcgc ctcctaaaag gtaacggagg cgcccaaagg 164521 ttccctcaga atggttggaa atcattcgca gagtgtaaag gcacaaggga gcttgactgc 164581 gagacctaca agtcgagcag ggacgaaagt cgggcttagt gatccggtgg ttccgcatgg 164641 aagggccatc gctcaacgga taaaagctac cccggggata acaggcttat ctcccccaag 164701 agtccacatc gacggggagg tttggcacct cgatgtcggc tcatcgcatc ctggggctgt 164761 agtcggtccc aagggttggg ctgttcgccc attaaagcgg tacgcgagct gggttcagaa 164821 cgtcgtgaga cagttcggtc cctatccgtc gcgggcgcag gaaatttgag aggagctgtc 164881 cttagtacga gaggaccggg atggacgcac cgctggtgta ccagttgttc tgccaagggc 164941 atcgctgggt agctatgtgc ggacgggata agtgctgaaa gcatctaagc atgaagcccc 165001 cctcaagatg agatttccca ttccgcaagg aagtaagatc cctgaaagat gatcaggttg 165061 ataggtctga ggtggaagtg tggcgacaca tggagctgac agatactaat cgatcgagga 165121 cttaaccata tttttgaatg atgtcacatc tgttatctag ttttgagaga acactctcaa 165181 tttgtttggt ggcgatagcg aagaggtcac acccgttccc ataccgaaca cggaagttaa 165241 gctcttcagc gccgatggta gtcgggggtt tccccctgtg agagtaggac gccgccaagc 165301 agatttatta attctaccat gtttgtttat gaagctttat attattccgc agtagctcag 165361 tggtagagct atcggctgtt aaccgatcgg tcgtaggttc gaatcctacc tgcggagcca 165421 ttgcttccat agctcagcag gtagagcact tccatggtaa ggaagaggtc agcggttcga 165481 gcccgcttgg aagcttaaat gtattattac caaggtttct cataaggaga aagctttttt 165541 tattgcgata tgcggaagta gttcagtggt agaacaccac cttgccaagg tgggggtcgc 165601 gggttcgaat cccgtcttcc gctccattta tcctaacggg atattgtaaa ttgaattgcg 165661 cccgtagctc aattggatag agcgtttgac tacggatcaa aaggttaggg gttcgactcc 165721 tctcgggcgc gccatatctt ttaatagaat agataggaaa tcgggaagta gctcagcttg 165781 gtagagcaca tggtttggga ccatggggtc gcaggttcga atcctgtctt cccgaccatt 165841 ttttatgggg ccttagctca gctgggagag cgcctgcttt gcacgcagga ggtcagcggt 165901 tcgatcccgc taggctccac caaaagtttt taaaaaagtt attgactttg aagaagtgac 165961 attgtatact aataaagttg ctttaacaaa gcggacaaac aaaatgatct ttgaaaacta 166021 aacaagacaa aacgtacctg ttaattcagt ttttaaaaat cgcacagcga tgtgcgtagt 166081 cagtcaaact actttatcgg agagtttgat cctggctcag gacgaacgct ggcggcgtgc 166141 ctaatacatg caagtcgagc ggacagatgg gagcttgctc cctgatgtta gcggcggacg 166201 ggtgagtaac acgtgggtaa cctgcctgta agactgggat aactccggga aaccggggct 166261 aataccggat ggttgtttga accgcatggt tcaaacataa aaggtggctt cggctaccac 166321 ttacagatgg acccgcggcg cattagctag ttggtgaggt aacggctcac caaggcaacg 166381 atgcgtagcc gacctgagag ggtgatcggc cacactggga ctgagacacg gcccagactc 166441 ctacgggagg cagcagtagg gaatcttccg caatggacga aagtctgacg gagcaacgcc 166501 gcgtgagtga tgaaggtttt cggatcgtaa agctctgttg ttagggaaga acaagtaccg 166561 ttcgaatagg gcggtacctt gacggtacct aaccagaaag ccacggctaa ctacgtgcca 166621 gcagccgcgg taatacgtag gtggcaagcg ttgtccggaa ttattgggcg taaagggctc 166681 gcaggcggtt tcttaagtct gatgtgaaag cccccggctc aaccggggag ggtcattgga 166741 aactggggaa cttgagtgca gaagaggaga gtggaattcc acgtgtagcg gtgaaatgcg 166801 tagagatgtg gaggaacacc agtggcgaag gcgactctct ggtctgtaac tgacgctgag 166861 gagcgaaagc gtggggagcg aacaggatta gataccctgg tagtccacgc cgtaaacgat 166921 gagtgctaag tgttaggggg tttccgcccc ttagtgctgc agctaacgca ttaagcactc 166981 cgcctgggga gtacggtcgc aagactgaaa ctcaaaggaa ttgacggggg cccgcacaag 167041 cggtggagca tgtggtttaa ttcgaagcaa cgcgaagaac cttaccaggt cttgacatcc 167101 tctgacaatc ctagagatag gacgtcccct tcgggggcag agtgacaggt ggtgcatggt 167161 tgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg caacgagcgc aacccttgat 167221 cttagttgcc agcattcagt tgggcactct aaggtgactg ccggtgacaa accggaggaa 167281 ggtggggatg acgtcaaatc atcatgcccc ttatgacctg ggctacacac gtgctacaat 167341 ggacagaaca aagggcagcg aaaccgcgag gttaagccaa tcccacaaat ctgttctcag 167401 ttcggatcgc agtctgcaac tcgactgcgt gaagctggaa tcgctagtaa tcgcggatca 167461 gcatgccgcg gtgaatacgt tcccgggcct tgtacacacc gcccgtcaca ccacgagagt 167521 ttgtaacacc cgaagtcggt gaggtaacct tttaggagcc agccgccgaa ggtgggacag 167581 atgattgggg tgaagtcgta acaaggtagc cgtatcggaa ggtgcggctg gatcacctcc 167641 tttctaagga tattatacgg aatataagac cttgggtctt ataaacagaa cgttccctgt 167701 cttgtttagt tttgaaggat cattccttcg aaacgtgttc tttgaaaact agataacagt 167761 agacatcaca ttcaagtaat acaagatatc acatagtgat tctttttaac ggttaagtta 167821 gaaagggcgc acggtggatg ccttggcact aggagccgat gaaggacggg acgaacaccg 167881 atatgcttcg gggagctgta agcaagcttt gatccggaga tttccgaatg gggaaaccca 167941 ccactcgtaa tggagtggta tccatatctg aattcatagg atatgagaag gcagacccgg 168001 ggaactgaaa catctaagta cccggaggaa gagaaagcaa atgcgattcc ctgagtagcg 168061 gcgagcgaaa cgggattagc ccaaaccaag aggcttgcct cttggggttg taggacactc 168121 tgtacggagt tacaaaggaa cgaggtagat gaagaggtct ggaaaggccc gccataggag 168181 gtaacagccc tgtagtcaaa acttcgttct ctcctgagtg gatcctgagt acggcggaac 168241 acgtgaaatt ccgtcggaat ccgggaggac catctcccaa ggctaaatac tccctagtga 168301 ccgatagtga accagtaccg tgagggaaag gtgaaaagca ccccggaagg ggagtgaaag 168361 agatcctgaa accgtgtgcc tacaagtagt cagagcccgt taacgggtga tggcgtgcct 168421 tttgtagaat gaaccggcga gttacgatct cgtgcaaggt taagcagaag atgcggagcc 168481 gcagcgaaag cgagtctgaa tagggcgcat gagtacgtgg tcgtagaccc gaaaccaggt 168541 gatctaccca tgtccagggt gaagttcagg taacactgaa tggaggcccg aacccacgca 168601 cgttgaaaag tgcggggatg aggtgtgggt aggggtgaaa tgccaatcga acctggagat 168661 agctggttct ctccgaaata gctttagggc tagcctcaag gtaagagtct tggaggtaga 168721 gcactgattg gactaggggc ccctaccggg ttaccgaatt cagtcaaact ccgaatgcca 168781 atgacttatc cttgggagtc agactgcgag tgataagatc cgtagtcgaa agggaaacag 168841 cccagaccgc cagctaaggt cccaaagtat acgttaagtg gaaaaggatg tggagttgct 168901 tagacaacca ggatgttggc ttagaagcag ccaccattta aagagtgcgt aatagctcac 168961 tggtcgagtg actctgcgcc gaaaatgtac cggggctaaa cgtatcaccg aagctgcgga 169021 ctgttcttcg aacagtggta ggagagcgtt ctaagggctg tgaagccaga ccggaaggac 169081 tggtggagcg cttagaagtg agaatgccgg tatgagtagc gaaagagggg tgagaatccc 169141 ctccaccgaa tgcctaaggt ttcctgagga aggctcgtcc gctcagggtt agtcgggacc 169201 taagccgagg ccgaaaggcg taggcgatgg acaacaggtt gatattcctg taccacctcc 169261 tcaccatttg agcaatgggg ggacgcagga ggatagggta agcgcggtat tggatatccg 169321 cgtccaagca gttaggctgg gaaataggca aatccgtttc ccataaggct gagctgtgat 169381 ggcgagcgaa atatagtagc gaagttcctg attccacact gccaagaaaa gcctctagcg 169441 aggtgagagg tgcccgtacc gcaaaccgac acaggtaggc gaggagagaa tcctaaggtg 169501 atcgagagaa ctctcgttaa ggaactcggc aaaatgaccc cgtaacttcg ggagaagggg 169561 tgctctgtta gggtgcaagc ccgagagagc cgcagtgaat aggcccaggc gactgtttag 169621 caaaaacaca ggtctctgcg aagccgtaag gcgaagtata ggggctgacg cctgcccggt 169681 gctggaaggt taagaggagc gcttagcgta agcgaaggtg cgaattgaag ccccagtaaa 169741 cggcggccgt aactataacg gtcctaaggt agcgaaattc cttgtcgggt aagttccgac 169801 ccgcacgaaa ggcgcaacga tctgggcact gtctcaacga gagactcggt gaaattatag 169861 tacctgtgaa gatgcaggtt acccgcgaca ggacggaaag accccgtgga gctttactgc 169921 agcctgatat tgaatgttgg tacagcttgt acaggatagg taggagcctt ggaaaccgga 169981 gcgccagctt cggtggaggc atcggtggga tactaccctg gctgtattga ccttctaacc 170041 cgccgccctt atcgggcggg gagacagtgt caggtgggca gtttgactgg ggcggtcgcc 170101 tcctaaaagg taacggaggc gcccaaaggt tccctcagaa tggttggaaa tcattcgcag 170161 agtgtaaagg cacaagggag cttgactgcg agacctacaa gtcgagcagg gacgaaagtc 170221 gggcttagtg atccggtggt tccgcatgga agggccatcg ctcaacggat aaaagctacc 170281 ccggggataa caggcttatc tcccccaaga gtccacatcg acggggaggt ttggcacctc 170341 gatgtcggct catcgcatcc tggggctgta gtcggtccca agggttgggc tgttcgccca 170401 ttaaagcggt acgcgagctg ggttcagaac gtcgtgagac agttcggtcc ctatccgtcg 170461 cgggcgcagg aaatttgaga ggagctgtcc ttagtacgag aggaccggga tggacgcacc 170521 gctggtgtac cagttgttct gccaagggca tcgctgggta gctatgtgcg gacgggataa 170581 gtgctgaaag catctaagca tgaagccccc ctcaagatga gatttcccat tccgcaagga 170641 agtaagatcc ctgaaagatg atcaggttga taggtctgag gtggaagtgt ggcgacacat 170701 ggagctgaca gatactaatc gatcgaggac ttaaccatat ttttgaatga tgtcacacct 170761 gttatctagt tttgagagaa cactctcaat ttgtttggtg gcgatagcga agaggtcaca 170821 cccgttccca taccgaacac ggaagttaag ctcttcagcg ccgatggtag tcgggggttt 170881 ccccctgtga gagtaggacg ccgccaagca attgcacatt agtgtaattt tttaaaaaag 170941 ttattgactt tgaagaagtg acattgtata ctaataaagt tgctttaaca aagcggacaa 171001 acaaaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca gtttttaaaa 171061 atcgcacagc gatgtgcgta gtcagtcaaa ctactttatc ggagagtttg atcctggctc 171121 aggacgaacg ctggcggcgt gcctaataca tgcaagtcga gcggacagat gggagcttgc 171181 tccctgatgt tagcggcgga cgggtgagta acacgtgggt aacctgcctg taagactggg 171241 ataactccgg gaaaccgggg ctaataccgg atggttgttt gaaccgcatg gttcaaacat 171301 aaaaggtggc ttcggctacc acttacagat ggacccgcgg cgcattagct agttggtgag 171361 gtaacggctc accaaggcaa cgatgcgtag ccgacctgag agggtgatcg gccacactgg 171421 gactgagaca cggcccagac tcctacggga ggcagcagta gggaatcttc cgcaatggac 171481 gaaagtctga cggagcaacg ccgcgtgagt gatgaaggtt ttcggatcgt aaagctctgt 171541 tgttagggaa gaacaagtac cgttcgaata gggcggtacc ttgacggtac ctaaccagaa 171601 agccacggct aactacgtgc cagcagccgc ggtaatacgt aggtggcaag cgttgtccgg 171661 aattattggg cgtaaagggc tcgcaggcgg tttcttaagt ctgatgtgaa agcccccggc 171721 tcaaccgggg agggtcattg gaaactgggg aacttgagtg cagaagagga gagtggaatt 171781 ccacgtgtag cggtgaaatg cgtagagatg tggaggaaca ccagtggcga aggcgactct 171841 ctggtctgta actgacgctg aggagcgaaa gcgtggggag cgaacaggat tagataccct 171901 ggtagtccac gccgtaaacg atgagtgcta agtgttaggg ggtttccgcc ccttagtgct 171961 gcagctaacg cattaagcac tccgcctggg gagtacggtc gcaagactga aactcaaagg 172021 aattgacggg ggcccgcaca agcggtggag catgtggttt aattcgaagc aacgcgaaga 172081 accttaccag gtcttgacat cctctgacaa tcctagagat aggacgtccc cttcgggggc 172141 agagtgacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 172201 cgcaacgagc gcaacccttg atcttagttg ccagcattca gttgggcact ctaaggtgac 172261 tgccggtgac aaaccggagg aaggtgggga tgacgtcaaa tcatcatgcc ccttatgacc 172321 tgggctacac acgtgctaca atggacagaa caaagggcag cgaaaccgcg aggttaagcc 172381 aatcccacaa atctgttctc agttcggatc gcagtctgca actcgactgc gtgaagctgg 172441 aatcgctagt aatcgcggat cagcatgccg cggtgaatac gttcccgggc cttgtacaca 172501 ccgcccgtca caccacgaga gtttgtaaca cccgaagtcg gtgaggtaac cttttaggag 172561 ccagccgccg aaggtgggac agatgattgg ggtgaagtcg taacaaggta gccgtatcgg 172621 aaggtgcggc tggatcacct cctttctaag gatattatac ggaatataag accttgggtc 172681 ttataaacag aacgttccct gtcttgttta gttttgaagg atcattcctt cgaaacgtgt 172741 tctttgaaaa ctagataaca gtagacatca cattcaagta atacaagata tcacatagtg 172801 attcttttta acggttaagt tagaaagggc gcacggtgga tgccttggca ctaggagccg 172861 atgaaggacg ggacgaacac cgatatgctt cggggagctg taagcaagct ttgatccgga 172921 gatttccgaa tggggaaacc caccactcgt aatggagtgg tatccatatc tgaattcata 172981 ggatatgaga aggcagaccc ggggaactga aacatctaag tacccggagg aagagaaagc 173041 aaatgcgatt ccctgagtag cggcgagcga aacgggatta gcccaaacca agaggcttgc 173101 ctcttggggt tgtaggacac tctgtacgga gttacaaagg aacgaggtag atgaagaggt 173161 ctggaaaggc ccgccatagg aggtaacagc cctgtagtca aaacttcgtt ctctcctgag 173221 tggatcctga gtacggcgga acacgtgaaa ttccgtcgga atccgggagg accatctccc 173281 aaggctaaat actccctagt gaccgatagt gaaccagtac cgtgagggaa aggtgaaaag 173341 caccccggaa ggggagtgaa agagatcctg aaaccgtgtg cctacaagta gtcagagccc 173401 gttaacgggt gatggcgtgc cttttgtaga atgaaccggc gagttacgat ctcgtgcaag 173461 gttaagcaga agatgcggag ccgcagcgaa agcgagtctg aatagggcgc atgagtacgt 173521 ggtcgtagac ccgaaaccag gtgatctacc catgtccagg gtgaagttca ggtaacactg 173581 aatggaggcc cgaacccacg cacgttgaaa agtgcgggga tgaggtgtgg gtaggggtga 173641 aatgccaatc gaacctggag atagctggtt ctctccgaaa tagctttagg gctagcctca 173701 aggtaagagt cttggaggta gagcactgat tggactaggg gcccctaccg ggttaccgaa 173761 ttcagtcaaa ctccgaatgc caatgactta tccttgggag tcagactgcg agtgataaga 173821 tccgtagtcg aaagggaaac agcccagacc gccagctaag gtcccaaagt atacgttaag 173881 tggaaaagga tgtggagttg cttagacaac caggatgttg gcttagaagc agccaccatt 173941 taaagagtgc gtaatagctc actggtcgag tgactctgcg ccgaaaatgt accggggcta 174001 aacgtatcac cgaagctgcg gactgttctt cgaacagtgg taggagagcg ttctaagggc 174061 tgtgaagcca gaccggaagg actggtggag cgcttagaag tgagaatgcc ggtatgagta 174121 gcgaaagagg ggtgagaatc ccctccaccg aatgcctaag gtttcctgag gaaggctcgt 174181 ccgctcaggg ttagtcggga cctaagccga ggccgaaagg cgtaggcgat ggacaacagg 174241 ttgatattcc tgtaccacct cctcaccatt tgagcaatgg ggggacgcag gaggataggg 174301 taagcgcggt attggatatc cgcgtccaag cagttaggct gggaaatagg caaatccgtt 174361 tcccataagg ctgagctgtg atggcgagcg aaatatagta gcgaagttcc tgattccaca 174421 ctgccaagaa aagcctctag cgaggtgaga ggtgcccgta ccgcaaaccg acacaggtag 174481 gcgaggagag aatcctaagg tgatcgagag aactctcgtt aaggaactcg gcaaaatgac 174541 cccgtaactt cgggagaagg ggtgctctgt tagggtgcaa gcccgagaga gccgcagtga 174601 ataggcccag gcgactgttt agcaaaaaca caggtctctg cgaagccgta aggcgaagta 174661 taggggctga cgcctgcccg gtgctggaag gttaagagga gcgcttagcg taagcgaagg 174721 tgcgaattga agccccagta aacggcggcc gtaactataa cggtcctaag gtagcgaaat 174781 tccttgtcgg gtaagttccg acccgcacga aaggcgcaac gatctgggca ctgtctcaac 174841 gagagactcg gtgaaattat agtacctgtg aagatgcagg ttacccgcga caggacggaa 174901 agaccccgtg gagctttact gcagcctgat attgaatgtt ggtacagctt gtacaggata 174961 ggtaggagcc ttggaaaccg gagcgccagc ttcggtggag gcatcggtgg gatactaccc 175021 tggctgtatt gaccttctaa cccgccgccc ttatcgggcg gggagacagt gtcaggtggg 175081 cagtttgact ggggcggtcg cctcctaaaa ggtaacggag gcgcccaaag gttccctcag 175141 aatggttgga aatcattcgc agagtgtaaa ggcacaaggg agcttgactg cgagacctac 175201 aagtcgagca gggacgaaag tcgggcttag tgatccggtg gttccgcatg gaagggccat 175261 cgctcaacgg ataaaagcta ccccggggat aacaggctta tctcccccaa gagtccacat 175321 cgacggggag gtttggcacc tcgatgtcgg ctcatcgcat cctggggctg tagtcggtcc 175381 caagggttgg gctgttcgcc cattaaagcg gtacgcgagc tgggttcaga acgtcgtgag 175441 acagttcggt ccctatccgt cgcgggcgca ggaaatttga gaggagctgt ccttagtacg 175501 agaggaccgg gatggacgca ccgctggtgt accagttgtt ctgccaaggg catcgctggg 175561 tagctatgtg cggacgggat aagtgctgaa agcatctaag catgaagccc ccctcaagat 175621 gagatttccc attccgcaag gaagtaagat ccctgaaaga tgatcaggtt gataggtctg 175681 aggtggaagt gtggcgacac atggagctga cagatactaa tcgatcgagg acttaaccat 175741 atttttgaat gatgtcacac ctgttatcta gttttgagag aacactctca atttgtttgg 175801 tggcgatagc gaagaggtca cacccgttcc cataccgaac acggaagtta agctcttcag 175861 cgccgatggt agtcgggggt ttccccctgt gagagtagga cgccgccaag caagcttaaa 175921 cccagctcat tgagctgggt tttttgtttt atatctgtgc cgatttgctt tcgtcagtat 175981 ccattttatc aagcttctgc tttttaaagt tttctaatac ttttgaattc caatacaatc 176041 cctagcatga tcaacatgag agtcataaat aatcaaaatg cagtttgtac gggagactca 176101 tccagactcc atccgactgc gattggcagg atagagccgc caatccattg gcagcgaaca 176161 gcatgcttgt cgtttgttct gtttttccat gataaaattg attggtgaca ataaaataat 176221 ggcgaacatg ccggccataa ataagtccta agaaaaaact aagaataatc cctgcaaaag 176281 ctgttttatt gattgccaaa atacagagtt aaatgaggcc gctcatattt atcagcctga 176341 gataatgatg ataggttatt ttttcggaaa ccagctcggg ttgccaaatg agagaaaaga 176401 tattactgtc attaaaacga ttcttggttt catccggata tgataaaatg tctcagacta 176461 tatttgagcc atttttttct tcagcaatca tcttgcgtaa ttgataaaaa tttattatga 176521 tactctttgt atgacaactc cttgcctcaa tacaatatac tcaacgtttc cccgttttct 176581 ccggtcgttt ttcttttcat tttctcccgt aaaataaaaa aagctcccaa tacaatagat 176641 atggtgcgga tttatttttt actaaaaagg agtcgttata tttgaataat agttttacat 176701 taaaacagca atggttcggg aatatccgaa aagacattct tgctggcatt ttagttgcgt 176761 tagcgttaat acctgaagcg attggctttt ctattatagc cggtgtggat ccgatggtcg 176821 gtctttatgc gtcattttgc atagccatta ttatttctat ttttggtggc agacctggca 176881 tgatttcagc tgcgacaggc tcaatggcag tcgttatggt gtcgctggtt gctgatcatg 176941 ggcttcagta tttatttgcg gctacgattt tgacaggcat tattcaggtg attttaggta 177001 tcagtaaaat tgcaagatta atgaaattca tcccgcgttc tgtgatgatc gggtttgtga 177061 atgcgctggc gatccttatc ttctctgcgc agcttcccca gtttgaaggt gcttcttgga 177121 gcatgtatgc gatgcttgcc gggtcgttgg ttattattta tgtgctgcca aggtttacga 177181 ctgctgttcc gtctccgctt gtggcgatta ttgtgatgac aattattgcg gtcactttcc 177241 atgtggatgt gcggacggtt ggtgatatgg gcaatatttc tagttcattg cctcatttct 177301 taatccctga tgttccgttt acctttgaaa cactgcaaat tatttttcct tattcaattg 177361 ctttagcgtt tgtcgggttg cttgaatctt tgctgacagc acagattatt gatgaaatga 177421 cggatacgga tagtgataaa aataaagaga gccgcggaca gggaattgcg aatatcgtga 177481 ctggattctt tggcggaatg gcaggctgcg ctatgatcgg acaatctgtc attaatacaa 177541 aagcgggcgg tcgcggacgt ttgtcagcat ttgttgccgg tgcttttctg atgtttttaa 177601 ttgcggtgtt aagtcatgtc gtggtgaaaa tcccaatggc ggcgttagta gctgtaatgg 177661 ttatggtgtc tgtcggcact tttgattggt cttctttaaa aggtctcaaa aaagcgccgc 177721 tcacggactc gattgtcatg gttgtgactg tggttacggt tgttgtgacg gatgacttat 177781 ctaagggtgt atttgtcggt gttcttttaa gtgccgtgtt ctttgtagca aaaatctcga 177841 agctgaaaat cgtttctcat gcagaggatc aaaagcttag aacgtatcaa gtgaaggggc 177901 aaatcttttt tgcgtcagtg actgatctta cgaatgcgtt tatatatcaa gaggatattg 177961 agcgggttgt gattgactta actgaagctc acgtatggga cgattctggt gcggccgcac 178021 ttgataagat tgttgcgaag tttaaggaac aaggcattga agctgagtta aaaggtttga 178081 ataaagcgag taaatctcta atgaaacaga tggcataaaa tagagaagcc cagatgaatg 178141 agatctgggc ttttttatat aacatacact taagcagcat tgatataata gagagaagag 178201 aaattttaaa taggggactt gcatatgatg cttcagaagc tgaaccgtgt attggggaga 178261 gtgatgccgc tgttaacgcc gactagtgtg gtgctgggcg tgctgctgtc tcagttttta 178321 aatgggtatg aatgggctgt gccttggatc tttgctttta ttacgtttgc aggcagtttg 178381 agcgcgaact ttcaatcttt gagacatgca ttgtctcatc ctctccctat gattcttgca 178441 ctattcgttc ttcatatttt catgccgctt tttgcttggg gcagcggcca tcttatattt 178501 aaaggtgatc ctttgacgat taccggttta acattggctg ttgtgattcc tacggggatt 178561 acaagcttga tttgggcagc gatgtacaaa gggaatgtcg gtttgacact ttcgattatt 178621 ttagttgata ctgtgctgtc accgctaatc gtaccgctga gtctttcatt gctggccggc 178681 gctcaggttc acatggatgt gtggggaatg atgaaaggtc tgattgtaat ggtcgtgatt 178741 ccttcttttt tgggcatgct gtttaatcag atgtcatctc cagaaagaac tgcgtttgtg 178801 agcagtgcgc tgtcgccttt ttcaaagctt tgcttgatgg cagtgattgc gattaacagt 178861 tcagcgattg ctccttattt caaatccatt gatttgagat ttgcaggaat agctgtaacg 178921 gtattcttta tcgcgttaac aggttatgcc gctgcttggc tgatcggaaa aatgatgaaa 178981 aggcggcaag aggaaatagt ctctcttata tttacgggag gcatgaggaa tattagtgcc 179041 ggcgcagttc ttgccgttac gttcttcccg tctcaggttg ccgttcctgt tgtgatcggc 179101 atgctgtttc agcagatatt ggctgctttg tttggctata tgctgaatcg ttttgaatta 179161 aaaccaatgt tgcagaaggc ataaaaaaac cgctcatagg gttgagcggt tttttccgta 179221 tagccattcg agcgcgttga tgaactgttt gcagaaatac ttgtggtggt gcaccgctcc 179281 tttttcaatt gaaagacaca actggtcttc agtgaagcct ttttctttta gactttgatg 179341 aacttgcttt gtttttttca gcatatgtcg ctgaatggat tgtttttcac ggccttcttc 179401 actcccgata gacatgaaaa cacgtgcagt gccgggcttt aaagaagata tatgaatggt 179461 ttccgctgcg ttctcgtacc agtatgaacc tgatatagag cctattttcc cgaacattga 179521 cggatatttt aatatggcga acattgagat gaggccgcct aatgaggcac cgatcattcc 179581 tcttgactgc ggttccctgg tgacgttcca gttttcttcg attagcggaa tgaactggtt 179641 cgttatatca gacagatagt gatatcccat tccgccgaag tccgtgaacc gatcactgag 179701 tgatgcagcc ggccatgggg tgtattcatc aagccggttt tcgggttcga taccgatcag 179761 cacgagttca gggagccttt gctgttgaaa ggcgctttct agtaattcga tttggttttg 179821 gaacaaagaa ctgccatcct gcacgtaaac agcaggaaat cccccgctgt ctgtgctgta 179881 ggaaggaggg aggtacagcg tgaacctcct gttgccggct ttgtgttctg aaagagatcc 179941 tttcaagcat tctccccctt tttttgcttg aaaagcagat ataagaaata aggaactccg 180001 aggatcgcca aaatgatgcc tgcgggcact tctgcgggct gaaaaaacag ttttccggca 180061 aagtctgcgc ttatcacaag aagcatcccg attaaaccgc tcagtggcag gatatagcga 180121 tgttcgacgc cagccagtct ccgtgagata tggggagcaa ttaagccgac aaacgccata 180181 cttcccgcta cggagacaca ggcgctgatg attgctacac aggcaacgag aaggatggtt 180241 ttttctttat ttgatgaaat accgaggctt ctgactgtgt cttcatcaaa acgaatggtg 180301 tcgagcaggc gggatttgcc gataagaatc ggtataaaca gcagcatcca tgggagtaca 180361 gctgtaatat acgtccagtt ggcagaccag atgcttccgt ttttccacac catggccatt 180421 tgatagtctt gcgggtccat ttttaaagat aaaaacaaag acagggcgct gaatcctgaa 180481 ttgatcgcaa tccctaccaa aataattctt cctgaatcta aattgcctct gtgccatgca 180541 aatatgtaaa tcaggatcgc cgcgatgagc ccgcctatca atccaaagag cggcattccc 180601 atcgctgcag ctatggatgt cacttccttc tggccttgga ataagagcat aaacgctaca 180661 atgccagctc ctgcccctgc gttgattccg agaattccag ggtcagcaag cccgtttctc 180721 gtgatggcct ggataacagc gcctgcaatg ccaagaccga gtccaataat agcagccatg 180781 acaacccgcg gcagtcttaa atcgaacagc aaaatttcat actgcggatt cgggtcgatt 180841 tgaaaaagag tggagagcag ctcagcagga cgaacagaaa atgatccgct cgttaagctg 180901 aaatagctga caacaagaat caaagcgatg aacaatgcat attttttagc cattttgctc 180961 ccctcctttt cgtttaatta aataaaggaa gaaaggtacg ccgataatgg atgttacgac 181021 ctcaatcggt gtttcaaacg gatagttgat aaatctgctt gcgagatcac acagggttaa 181081 aaagattccg cccaaaatac aggaacacgg aatcagcctg ctgtaatcag agccgacgag 181141 aaatctcgtg atatgcggaa caaccaaccc gacaaacgca atttttccgg ccagcgctac 181201 ggcactgccg gttagaatga tgacggaaag catcgccatg attttaatgg tttttttctt 181261 ttgccccagg cttttagaaa tgtcgtcccc taatgataca gcggttacct ttttgctgag 181321 agaaatggcc attataatgc caatcaggaa aaacggagcg gcaagcttca ggaaatctgg 181381 actcatttga tgaagtctgg cactgtacca gaaactgaga tcctgagaaa tttgaaaata 181441 aatcgacatg gccgctgata agctgctgag cagcatgctt gtgactgtgc cgatgatggc 181501 gagctgcacg ggggtaaatc cgtttggcat catggcggca aggccgaata ctaacaccgc 181561 tcctaacgct gagccgataa aagagtatat catcatttca atcgaagatg attgcgggag 181621 cagaaccatg caaagcgtaa tgataaacgc tgaaccatct gaaacaccca taatggatgg 181681 cgaagctaaa taattgcgcg taatgccctg cataagcgct ccagaaacag caagggctgc 181741 ccctatgagc agagcgccgg cagcccttgg aatccgggaa tgccatataa tttgatggtc 181801 tgtgtttccc ggatcgaaat gaataagaga tgtaaaaaca atatctgtgc tgagatgctt 181861 tgccccataa aggattgaaa gcaaaagtga cagcgctata gcaaatggag aagtaatcaa 181921 tatgatacgt gtccactgtt ttgaatacat acaaaaacct actctgaatt agttttgtgt 181981 caatttttca gcagccgctt tcaggaaacg gactttgctc caagctgtgc cgccttgtgc 182041 gagagggtcc actgagttga catacacatg gtcttctttg actgctttaa ggcttttcca 182101 gattggattt ttctctaaat cttttaaggc atcaggtttg tctgcatttt catcatcaga 182161 aaattggacg aaaatatggt ccgggttcat ttcacttaat ttttctaatg aactcagctc 182221 ttgcgctttt gcagccttta cttcgttcgg cgccttaagg cctaaatcac cgtatagtgt 182281 ggagttgaaa tacacctgtt cagggtaaat gtaaatgttg ccttgtctga ttctgatgac 182341 aagcgctttt gaatctttcg ctttatcgtt gatttttgtt tttatttctt ttagatcctg 182401 ttcatagtct gcaataattt tctttgcttt tttctctttt ccagtcagct gggcaagaag 182461 catcatgttt tccttccagt ttgaagagat atgagaaact gggatcgtcg tgcctgctgt 182521 gctgattttt tgcagcgttt tttccggaaa ctttgttgaa gcaaggataa catctggctt 182581 catttcaaga atcttttcaa tatttggctc cattttttct ccggttggtt cggctttatc 182641 agtgatgtct ttgaacatat cagggaattt gccggagaat gaaattgcgc cttgcggatg 182701 aacgtcaagc aatttcgcgt cttccattga ttcaacgctt cccgtaatgg caattttgtc 182761 tgtcggtaca gttacttcat atgttttatc aaggtattca attttcttct tctcagatgc 182821 tgtgccgctt gccttgctgg cagttgattc atttttgctg ccgcaagctg ccgccgtcag 182881 cgcgagaagt aagattaata aggtaagaga tatctttttc atctatagag cctcctgttc 182941 aattgataac tattatcaat tggaattata gagaatgaac agatataaca ccatggacaa 183001 attcctgatt tatcatggac aatctccgga tagtaaagaa acagtttgct gaacgatgcg 183061 ttcgtgcccg caagctgagt attcattcca cgggtcaagg gatagaagat aaacacggtt 183121 atctcgtacc gcgcttaggt tttgccatgc ttctgtctgc tgtaattgct ggtagtaagc 183181 tatggtctcc ggctctttaa aaagaaaaag catcatacag tcagcttggt aatttgcgat 183241 attttctaac gaaatcgctt gttctgaagg tgtgtcagcc gttgttgccg agctgaatcc 183301 taaatcccca aagaaaactt cgcggacact tcggttatga gccagataga agttttgctt 183361 atgcagcctc aaaaagagaa aacgcagccc ttgaacgtgc tgaagtgttt ttttggcggc 183421 cgttgtctgc tggtcataat ccgctagcca cttttctgct tcggactcct cctttaaaaa 183481 tgaggcagtt tgcagaaagt gggttctcca gctttcttct gaaggaaggt acatgacttc 183541 tgcgatgcga ttcaggcgat cttgttcttc tggagaaata gaatccatgc tgacaatcac 183601 atctggttct gcctgtgata acgtgtacag gttttcttcc cacttttcat taaaccggta 183661 tgcactgagc tggacgggta tatctgtcga ataatgctga tagtagtaag acgtccattt 183721 cggatgcaga gcggccgcaa aaggtatgtg gtgaagaggg atgagatggc ccattgtgcc 183781 ccttccgtat gcggcgattt tctttcggcg ttttttcata tagcttgtag gtgaacagcc 183841 tgtatatttt ttaaagattc tgctgaaata aaattcatct tgataaccgg tttggtgtgc 183901 gatttctttc aatttgcagt ttgattttgc catgagccgt tttgcctttg tgattcgtgt 183961 tttcgtaata aattctgtta cgctctgtcc tgtccatttt ttaaagcttt cactgtagtg 184021 tttggcactg attcctgcca tttgcgacag ctgggcaagc gtgatttttg tatcggcatg 184081 ggtttcgata tagtgttttg ttttttcgat tgctgaatgt gtatccgttt gatcagataa 184141 actggcagta aaaagatcat aaatcaggct ttgtacttca atcacacatt ttagctgaga 184201 aagctgagac gattcattcc atagtgcggc aagctcttga agccggactg caagattttc 184261 gatatgtgaa acattcataa gcttcagttt ggctaattcc gattctgtgc acggtgtgaa 184321 aatatcttgc ccggtttcct tgatatagct tagaagcctg attatacagg catctatatg 184381 tccatcggct gctggcgtaa agccaaaggt ctcgttaggc ggacaaacat aaagtgtctt 184441 tttttgcaga ggattggtgt ttgttccgat cgaaatatag ccgtttcctt ttaaatgaaa 184501 aatcagcacg aatgaatcgg ctaattgctg ttctgagaag agatcacttg tcttttttag 184561 atattcaatt tgtactggtt gataaatcac tgcattttgc acgagtagac caccttttca 184621 gaagctttca attgataatc attttcaata aaaattgtac caaataaatg aaagttttcc 184681 tatataaagc gggtgggttt ttagcatgaa aaaaaccctt acttatgtgt aaaagtaagg 184741 gtctttcgtt caataagaat atgttacacg tgtaacatac gatgcttatg ttctaataaa 184801 tgagatactt ttttcttgtt ttgctgaatt gttggagtgt tttttcatag ctgtttatga 184861 tgttctcaac cgaagttcca ttttcaattt ttgtcctgat ccagccgttg cctgccagtt 184921 tatcgaatga acctgttgac aggaactcaa aatcctcagg atagagatcg tgtatggttt 184981 taatgactga aagacccgtt ttaacggctt caaacttatc tctgtctgtc acatagagct 185041 gcacaccgtg gcaaagcgtt ccttgatgtt tagaaaacgt cggtgtgaag gatgctgccc 185101 taaatgtaac gcccggcaaa tggaggctgt ttaatgtttc ttcaagttct gtgcttttga 185161 taaagggagc tccgatcaat tcgaatggct ttgttgtccc tcgcccttcg gatatatttg 185221 ttccttcaat cagcccggtt gcaggataaa caaatgtgct ttccaccgtc ggcatgttag 185281 gcgaagggag gacgaaaggc aatcgggtat cgtcaaaatc catttttcgt ttccagtgtt 185341 tcatttttac cactgtaaga tcggcatcaa tactaaattc tttgttgaac agtgaagcca 185401 attcgcctat cgtcatccca tgcttcaatg gaatgggata caatccgaca aatgaggcgt 185461 attcaggttc taagattggt ccttcaatat gattcccgcc ttgaggattc ggacggtcca 185521 gcaccataaa tggaatgccg ttttctttag cggcttccat tgcgtatgcc attgtataaa 185581 tgtacgtgta gaaacgggtc ccgacatcct gaatgtcaaa cattagaata tcgacatttt 185641 taagcatttc tggagtcggt tttttcgttt ttccgtagag gctgtatacg ggaaccccgg 185701 ttttttcgtc aatgtaagag cctacttcgt ctccagcctg ggcgtcaccg cggacgccgt 185761 gttcagggcc gaataaagct gtcagtttga tatccgggtt ctcgtaaagg atatcgacac 185821 tgctttttag agatgtgttt actccggctg gattggtgat cagtccgatg cgttttccct 185881 tgagctgttt tttatagtct ggcaagagcg tgtctatccc agtctggact ttaggttttt 185941 tagctgtttg attctttgaa tcgggtgaag cagaggcagc ggttatcgtt ccgaacatca 186001 tgagccctgt cagaaaagcg aatattgttt ttctcatgtg tccctcctta ttaaagcggt 186061 cttcccgttt tgatatttaa tccgtagcca agtgggtaaa gggtgttccc tggtttcgtg 186121 actgacggaa tgtcaactgg aagtgtgcct ttaggttttg cctggccgaa tatcgccatc 186181 actccggccg gaatattagg ttgaagataa cggccatttg cgtatccttt aaagccatag 186241 actgcaatca gtgcttttgc ttcttcgaaa ttggctgcgt cataggggtt gcgcaggctc 186301 attaagacaa atggtttgtt gtgctgcagt gcggctttca tgacagctct cggaaacacg 186361 gtggcccatt tgcttgaatc tgatattgtg tcgtcgatga caccgtcgtt gacgacaggg 186421 tcatttttga cgacatagga gccggtaatg atataatcag cctcttttac ttgtttttca 186481 tgctcggtct taaatacttg gctggcaaag ttcattttgc tgagggatac gggtttgatt 186541 ttctttcgct tgatgagatc gtgaatggtt tgttcgattg aagcagtttg ttcttcgtaa 186601 ggtgccacaa ttaagattcg gctgcctttt ttaggcttga acggcaaagt gtgctgttca 186661 ttttttaata cagttactgc tttttcagct aattttttct ctgctttcag gtgctgcttg 186721 cttcctacga tttttttggc tttggctatt ttttcttttg tactgtcgct gtttcgcgct 186781 ggatacatgc cgcgttttat tttcagggaa atgattcttt caactgaatt gttgatttgt 186841 tgttcaggaa tatccccgtt tttcacggct tctttcaaag cttgaataac acgtgcgaat 186901 ttctgttctt ctttcaatga agtgactgag gctggcatta atgcaatatc gacaccagct 186961 tttacggcca tgaccacagc ctcttcctgt ccgaaatgat ctgcgattgc cttcatattg 187021 agcgcatcgg taacgatgac cccattaaag cccatttcct gacgaagaag acctgtcatc 187081 actttttttg aaagtgtagc tggaaccaga atgtccgatc catcgagttt gcttttgtaa 187141 gtggtgtcat caaaggcggg aaactgaaca tgggctgtca tcaccatatc agcaccagca 187201 tcaattgctt tttgaaaagg ataaagctcg acctcacgaa gccgttcttg gccatgggaa 187261 acgagcggca gtccataatg gctgtcaacg tccgtgtctc catgtcccgg gaaatgtttg 187321 agggcagacg cgatatcctg ccgctgcaac cctttcatcg tatataaacc gaggcgtgat 187381 gtcagttctc gattggagct gaatgaccgt acgccgatta caggattatc aggattattg 187441 ttaatgtcca cgacagggct gaaatctgta ttgatgccta aggcagagag ctcttttccg 187501 atgatgctgc cggtctgata cgcattgatt ctgcttctgg ctgcgcccag cgccatattc 187561 cctgggaaat tagtgccctc ccctaacctc gttacaatgc cgccttcctg atcaatactc 187621 agcatgagcg ggatttttgg acttgccttt tggtaatcgt ctgtcagttg gacagtttgt 187681 tttgttgttt ttacattttc tgcaaaaagg atgatgcctc cgaattgata tttcttgacg 187741 aggctggcga cttcatcatt catttttgta agggcttgcg gagaggactc gccttccttt 187801 tgccaatttc taaaatcagg catcagcatc tggccgagtt tttcatctaa cgacatacga 187861 ttgacaatct gattggcatc gattgcacgt ttggatgcag aggcttctgt ctgtctggcc 187921 ccgaaaaagc atgaaagaaa gagaacggct gaaaggataa gcggaaagac aggtctcata 187981 gaaacttcct cctatcgtct aatcattcac tccatcgctt cataaatcgc ggttatgaca 188041 cttccataac tgcctgttgg aaattggtca ccttcaaaga cgttcggatt ttcttccgga 188101 tcaataactg gtgtatgctt tttatttgtt aacaatgcga tgcctaaatt gtatgctgga 188161 tcaataattg taactgtccc cgtccagccg gtatgcccgt aagcattttc gctggcatga 188221 gggccaaaca tccattccat gcttttactt ccgttccgcc tccagccaag agcgaatgtc 188281 ggatctgttg ctgaaggtgc tgtaaacagg tcggctgttt tctgatcaaa taaagaaatg 188341 tttcggtatg aacctttgtt taacatgact tgcagcagta tggccatatc atctgcattt 188401 gagaacaatc cggcatgccc agacacgccg tccattgagt aaaacgcttt ttcgtcatgc 188461 acctctcctt gcagcgtgtt tgtgcggatg ttagggaatt gaataacgcc gtcacgtgta 188521 ttgcccatgc gttcagtagc tgcgaactgt ttcggtttaa agcccttttg cagcggattg 188581 tacaaggtat gcttcagcct gagcggtttg tagagctctt gctccgtgta gacatcaagc 188641 ggtttgccgg tgagtttttc gacaatacat ccgagtagca tatatccaat gtcactgtat 188701 acgtgttttg tcccggtttg ataatcgagc ggaattttcg tcaaatattc aatcgttttg 188761 tcccgttctt gggaatagta cttgccggct ttttccggcg tgtaaaagta aaagcttgat 188821 gggagccctg attggtgctg gaggacatca atgacacgta tcttgtcttt tccttttatg 188881 aggtcacccg gctgatcctt gaaacccggc aaatatgcag aaactttttc atagacgtca 188941 agttttcctt ggctgactaa gcgctgcaat gcaaaatttg ttgcgtacat ttttgtattt 189001 gaggctaagt caaacatcgt gcgggttttc attttggccg gacggcgcag cagttctgat 189061 ccttcgtact ttttactgta gccgtatgct gcttttttta tgatgcgtcc atccttcacc 189121 accacaagaa cggcgcctgg aaatcctgct gcaatatccc gttctatcat ctgatctacc 189181 ttccttagct tcttcgtcga gaattgtgca gtttctgcat ttatgatttt cggctcaatc 189241 aagttgcctg ctgtttgtgc gaaggtttca tttggcgcaa atatcgatag ggttaaaatg 189301 gcactgaata tgaacagtgt ctttgttttc acaggctagc ccctttctgt gcttctatcc 189361 cgtttactat ccctaaaaca gaaacaattt aatcgaactg agaagccatt tcatctttat 189421 atccgaatgc ataggtcaat aaaaaaccgg ccgcgtagga aataaagagc ccaacgatat 189481 acaggatgat ttgcgaaggc aggactagaa aagatagcgg cagtccggag acaccaatcg 189541 caatggtggc tacttgaaaa taagcttgaa aggcgccgcc gattccagct cctaaacatg 189601 ctgttaaaaa cggacggcca agcggcagcg tgactccgaa aataagcggt tcaccaatgc 189661 cgagcagtcc cgatggaagc ccgccggcga ttgctttcct cagtgttgtt tttttcgtct 189721 tcacgaaaac ggcaaaggcc gcgcctacct gtcctgcacc tcccatagcc aaaataggga 189781 gcagaggatc attgccaatt gaattgatca gttccatgtg cacaggcgtc aagccttgat 189841 gcagtccggt tacgacgaga ggaaggaagg ttgcgcccag aataaagccc gcagcgatgc 189901 cgccgatgtc caggatggac agtaggccgg atgtaatagc atcagaaatg aatccgccta 189961 aaggcataaa tacgacatac gttacgattc cggtgattaa cagtgaaacg gtgggtgtga 190021 caatgatatc aagtgattga ggaataaaac ggcgaataaa ttgttcggtg taagcaatga 190081 atatggctgc gaaaaggacg ccgatcagac ctcccctgcc cgggagaagc tcttctccaa 190141 ataaactgat ttttgcgatc tccggattga taatcaagat cccggccaaa gccccaagtg 190201 cgggtgtccc gccaaattct ttcgaagcgt taataccgac gagaatgccg agataagtga 190261 acagccctga tccgatgact gtcaggataa tcgcaatttg tgagtctgca gagagccagc 190321 ctgcttgaat aattgctttg gtaatcccag taattaaacc ggaagcgact agagcgggaa 190381 taagagggat aaaaatgctg gcaattttac gtaagaaaag tttaaaagga gtggcatttt 190441 tccgattgat atcggctttc tttttggccg ctgcttcttt gacatcggca ccttcttctg 190501 ctgacacgag ctttgagaaa gcagctgtaa catgattgac aactcctgtg ccgaggataa 190561 tttgtaaggt ttcagcttca acgaccccca atacgccgtc aagctttctt aaagcctgag 190621 catccgcttt gctttcatcg taaggcgtaa tgcgcaggcg tgtcatgcaa tgcgtatatg 190681 aagaaatatt ggattttcct ccgcatagct caaggatttt ctgtgcgaga tgatggtagt 190741 tattttcttt gctcattaaa acccctcccc ttcaagatgc cttattttat tctcatagat 190801 tgtatggctg ctctcgtttt atctatataa ccggttgtcg tttcatactg ctcagccgcc 190861 atgcctaaaa acaaaacatc aattataaaa agctgggcga ggcgggaaga agtggctgca 190921 cttcgaatca aggcttcatt ggaatgggct gtatacaaag ggacatcagc cagtgcggag 190981 acggatgtct gactgaattg tgtgaggctg atcgttgtga tgcctttttc cttagccatg 191041 gcgaacagtt caacgatttc ctgtgtctct cctgaaaacg aaatggcgaa tacgatgtcg 191101 tctttatctg catttgcgat taaagatgcc acaagatgag tgtctgtaaa cgcggttgct 191161 tgtttatgaa tgcgaagcca cttttgctgg gcgtccttgg cgacaatgcc ggaagccccg 191221 aggccgataa aatgcacggt atgagctttg agaagcagag aaaccgctcg ttcaagctct 191281 ttgtagtcca tcaggtctga agtatcctga atggcttgaa tggcattgcc ggccgttttt 191341 tcggaaatgg agggcagcgg ctcgtgggga acaatatccc ggtagccctg aaacgtaggc 191401 tttgccagat cgcctgctac tctcattttt aaatcttgaa atccttttaa accgagtgat 191461 ttgcagagcc tgatgacggc agcgtcactt gaattggcta aggcgctgat ttcgttgacc 191521 gtgctttcga ttgctttgtg gggatgggct aggatataat ctgcaagttt gcgctcggat 191581 ggagggagct tatgcttcat tgattggatg atcgctaaac cgcctgtggc cattctagtt 191641 ctctccttat catggatggt aatgttcgat tgctttgtca atgaaaccgt ttgcttcatc 191701 gagtaatgtc tgtgcttgtt tctgatctgt gcttgttttg agcatgacga ttgctgtttt 191761 gacgtgatga tcggcttgtt ccagagtgta tctggctgtg tcgtatgaag cgtttgtaag 191821 gctttggatg atgctgatgg cgcgttcttt tagttttttg ttgctgacgt tgacgtctac 191881 catcaagttt tcgtaaacct tgccgatttt gaccattaca gcggtagata tcatgtttag 191941 aatcatttta tgagcggttg cggctttcat acgtgttgat cctgtaatgg cctcaggtcc 192001 gacgacaacc tcaatgctgt gatccgcatc cttgctgatg gcggaatttt cattgcaagt 192061 aagggcgatg gtgtgtgctc cgactttacg ggcgtatctt agggcgcctg cggcgtaggg 192121 tgtgcggccg cttgctgcga tggcaatgac ggtgtcattt gaagtgagct gtatgtttct 192181 taaatcttca gctcctgctt cttcactgtc ttcaatgccc tctgctgcct gtaaaaaggc 192241 ttcggggcct ccagccatga ttccgatgac ctgatctggg cttacgctgt aggtgggagg 192301 acattcaaca gcatccatga cgccgagtct gccgcttgtg ccggcgcctg tatatatgag 192361 ccggcctcca ttttgaaacg attcatatgc gcagtctaca gctgttttga tgtcggggag 192421 aacctcctga acggctgcag cgactttcat atcttcgttg ttgatcattt taaggatgcc 192481 gagagtgttt gctttgtgga tttcaactgt ttgactattg cgtgattccg ttgtaagacg 192541 gtgaaggttt aatggttctg acatgaggat gccccctgtt ttaaaatgat atatctcaat 192601 attcagtata ttcatttctg ttatgatatt tcaactatgt ttttaaattt ttgaaatttt 192661 atttcactta agactataag aaatgatgaa ggatcaactg ttctccaagc ggcccgattc 192721 ttcgccgtcc tttatcaagg aacccgcttt tcatataaag gtgttttgcg cgtatgttca 192781 gatgattgac ggccaagatg atttcgtcgc accatggaaa atatccgctc acaaaagcgg 192841 gaagcaaaag catggctttt ttcgcatagc cttttccgtg atgcacagcg gttaaagaca 192901 gggagctgag cagtaaagca aatggattgt tagaatagga agcaagcgtt tcttttgatg 192961 catgtaaaat gaaaaaaccg actggaaggt cgtcttttaa gatgacaacc gggtatcggt 193021 cctgtatgcc cagagcctga gacagcacct ctttcgggag ggaggtaaag cgtttgtcat 193081 cgttggtgag cgtgaatgat tggagctcgg gcaagtgttc aggcttatag aaggataaag 193141 aaatgtcttg agtcatgggg tggcctcctt acaatatgtc gttaagctcg ttttccgaaa 193201 tgacgcggta gcccgcttgt tttaacagtg cggcggttac tccgctgccg gtgatttttt 193261 tgccagagaa tgtgccgtta tagataaaac cgcttccgca agatggactg ttttctttta 193321 atatgacggc agaagcgttg atttcttttg cgtaagccaa tgttttcgcg gcgccttcca 193381 tatatagttc tgtgacgtct tctcctgaag ctgtcacgat tttcgctgtt ccattgagga 193441 catcctcgcc agtgcctcct atgatttctg cgggttcgcg tggggtagag aagccgccga 193501 gaagttcagg gcaagccatg actgctttct tttcatcgac tagttttctg attttctccg 193561 acgctgcgtg agagccgtta tatctgcatt caatgcctcc aaggcaagaa ctgactagaa 193621 tcatattggt ttctcctctc ttgctttgct tgtctctatc ataaaataaa tggctttagt 193681 tgggaggctt tttcagttaa aaaaggagtt aaaaagtttg aaaataaaaa atttaatttt 193741 cctctttaca aacagggggt gacctgtata taataacttt tgtcagctcg acgagaacac 193801 aacggcccgt tggtcaagcg gttaagacac cgccctttca cggcggtaac acgggttcga 193861 atcccgtacg ggtcaccatt tggaggatta gctcagctgg gagagcatct gccttacaag 193921 cagagggtcg gcggttcgag cccgtcatcc tccaccatct tgccggtgta gctcaattgg 193981 tagagcaact gacttgtaat cagtaggttg ggggttcaag tcctcttgcc ggcactgttt 194041 tttcaaaatt ttatgtggag gggtagcgaa gtggctaaac gcggcggact gtaaatccgc 194101 tccctcaggg ttcggcagtt cgaatctgcc cccctccacc attattgggc tatagccaag 194161 cggtaaggca acggactttg actccgtcat gcgttggttc gaatccagct agcccagtca 194221 cagacacctt tgatcaaaag gtgtcttttt tcttttcgga aaaatcattc caacttctaa 194281 ctgttcagtc tgtataataa ttttaaaaat atgttaaggt agtttattca cgaattacca 194341 tctacaccct gccaaaaatt tgataaactt attttataaa aaaattgaaa ccttttgaaa 194401 cgaagctcgt atacatacag accggtgaag gcagaggtta gataaatatg gaaatgatga 194461 ttaaaaaaag aattaaacaa gtcaaaaaag gcgaccagga tgcatttgcg gacatcgtag 194521 atatttacaa agataaaatt tatcagcttt gctaccgtat gcttggcaat gtgcatgagg 194581 cggaggatat tgcacaggaa gctttcatca gagcgtacgt taatatcgac agttttgata 194641 ttaaccggaa attttcaact tggctttatc gaatcgcgac caatttgacc attgaccgca 194701 ttcgcaaaaa gaagccggat tattacctcg acgcagaggt ggctggtacg gaaggcttga 194761 ccatgtattc tcaaatcgtc gcagatggtg ttttgcctga agatgcagtt gtatcgctgg 194821 agctctcaaa cacgatacag cagaaaattt taaagcttcc tgacaaatac agaacagtca 194881 tcgtattaaa gtatattgac gaactctcat taattgaaat cggggagatt ctaaacattc 194941 ctgtggggac tgtgaaaacg cggattcaca gaggcagaga ggctcttaga aaacaattaa 195001 gggatcttta agtggggtga tgaaatgagc tgtcctgaac aaattgtgca gcttatgcat 195061 atgcatcttg atggagatat ccttccaaaa gatgaacacg tattaaatga acatctggag 195121 acatgcgaga aatgcagaaa gcatttttac gagatggaga aatccatagc gctcgtacgg 195181 agcacatcgc atgtcgaagc ccccgcggat tttaccgcta atgtcatggc aaaattgcct 195241 aaggagaaga aaagagcttc tgtaaaaaga tggttcagaa cccatcccgt tatcgcagct 195301 gctgcggtat tcatcatttt gatgggcggg ggttttttta acagctggca taatgaccac 195361 aatttcagcg tgtccaagca gccgaatctt gtggttcata accatactgt gaccgtgcca 195421 gaaggtgaga cggtcaaagg tgatgtcact gtcaaaaacg gcaagctgat tattaaaggc 195481 aaaatagacg gggatgtaac cgtcgtaaac ggcgaaaagt atatggcctc tgctggacaa 195541 gtcaccggtc agattgaaga aatcaatcag ttattcgact ggacatggta caagatgaag 195601 tctgcgggga aaagtgtact cgatgcattc aatccgaacg gagaagagta aagcgcgtta 195661 gccgctttgc tctttttttg cgggctgaga gggctggcac atttcacttg ctaaatcgaa 195721 atgtggtata atgggctcgc tatgtaaagt acatatgcgt aacacgtaaa acacaaaata 195781 cgaaatgact gaaatcttgg aggacgagga aatggctttt gaggatatcc cttttttgca 195841 gtacctcggc aatgccgttg atattctcct tgtttggtat gtgatatata aattgattat 195901 ggtgatacgc ggcacgaaag cggttcagct gttaaaagga attgtagtca tcgtgcttgt 195961 tcgtatggcc agccaatatt tgggcctcag cacacttcaa tggctgatgg accaagcgat 196021 aacatgggga tttttagcaa ttattattat ttttcagcct gagctgagaa gagcgcttga 196081 acagctaggc cgcggccgct ttttttcgag gagcggcacg cctgttgaag aagcgcagca 196141 gaaaacgatt gaggccatta caaaagcaat caattatatg gcgaaacgcc gtataggcgc 196201 cctgctgacc attgagcggg atactggaat gggcgattat attgagaccg gcataccact 196261 aaatgccaaa gtcagctctg agctgctgat caatattttt attccaaaca ccccgcttca 196321 tgacggtgcg gtaattatga aaaataatga aattgccgcg gccgcctgtt atctgccgct 196381 ttctgagagc ccgtttattt caaaagaact gggcacgcgg cacagagcag ctgtcggtat 196441 cagtgaagta acagacagtt tgacgattat tgtgtctgaa gagaccggcg gcgtcagtgt 196501 ggcaaagaac ggcgaccttc acagagagct tacagaagaa gcgctgaaag aaatgcttga 196561 agccgagttt aagaaaaaca ccagagacac ttcttctaac cgctggtatt ggaggggcaa 196621 gaaaaatgga taaattctta aacaaccgct gggctgtgaa aattattgct ctgcttttcg 196681 cgctcttgct ttatgtggcg gttaacagca accaagcacc gactccaaaa aaaccgggtg 196741 aatctttctt tccgacatca acaactgatg aagcaactct gactgatatt ccggttaaag 196801 cgtattatga tgatgaaaat tacgtcgtga cgggtgttcc gcaaacggtt aatgtcacga 196861 taaaaggctc gacaagcgcc gtgaaaaagg ctcggcagac caaaaacttt gaaatatatg 196921 ccgatatgga acatttgaaa accggcacac ataaggttga gcttaaggcc aaaaacgtgt 196981 cggatgggct gacaatctca attaatccgt ctgttacgac agtgaccatt caggaacgga 197041 cgaccaaaag ttttcccgta gaagtggagt actacaacaa aagcaagatg aaaaaaggct 197101 attctccgga gcagccgatt gtcagtccga aaaatgtgca gattaccgga tcgaaaaatg 197161 tgatcgataa tatttctctt gtaaaagctt cagtgaattt ggaaaacgca gatgaaacga 197221 ttgaaaagga agcgaaagtg actgtctatg ataaagacgg aaacgcgctt cctgtcgacg 197281 tggagccctc ggtcatcaag attaccgttc cggtgacaag cccgagtaaa aaagtgccct 197341 ttaaaattga acggacagga agccttcctg acggtgtcag catagcgaat attgaatcca 197401 gccccagtga ggtaacggtt tacggctcac aggatgtgtt ggattctctt gaatttattg 197461 acggcgtcag cctagattta agtaaaatta acaaggattc cgatatcgag gcagatattc 197521 cgcttcctga cggtgtcaaa aaaatctcac cgtcaaaggt gactttgcat atagaagtcg 197581 atagtgaagc ggatcagaag ttcgagaatg tccctatcaa gactgtaggg ctgagcagct 197641 cacaaaacat tgaatttctt gatcctgaat cacaagcgat agatgtaacg gctaaaggct 197701 ctcccacgaa tataaataaa ctgaaaaaat cagatattga attgtatgtg aatgtttcag 197761 atttagagga cggggagcat agcgtgaagc ttgaagtgaa cgggccacag aatgtaactt 197821 ggtccttggg gcggaaaaac gccaaaatca agctgacgtc taagaaaagc aatacatcaa 197881 cgaatgataa cagcagcaat acatcaggga accaggacac agataaacaa acaaatgatc 197941 aaaagaacaa tcagcaagaa gatacaaaga acactgataa aaacaacaac gatcaaaacc 198001 aagacggaaa taaagatcaa aaccaagatc aggatgagga tgaatccact gcgaattcac 198061 aatcctcatc ggaataaaaa aggagcgatt ataaaatggg caagtatttt ggaacagacg 198121 gtgtaagagg tgtcgccaat agtgagctta cacctgagct ggcctttaaa gtcggacgtt 198181 tcggcggtta tgtgctgaca aaagacaaac aacgtccaaa agtgctgata ggccgcgata 198241 cacgcatctc cggccatatg ctggagggag cccttgtcgc cggactttta tccattggcg 198301 cagaagtcat gcgcctgggt gtcatttcta caccaggtgt atcttatttg acaaaagcga 198361 tggatgcaga ggcgggcgtc atgatttccg cttctcataa cccagtgcag gataacggca 198421 tcaaattctt tgggggagat ggatttaagc tttctgatga acaggaggct gaaattgagc 198481 gcctgatgga cgaacctgag gataagctgc caagacctgt cggagcagac cttggacttg 198541 taaacgatta ttttgaaggc ggacaaaaat atctgcaatt cttaaaacag acagctgatg 198601 aagatttcac aggcattcat gtggcattgg actgtgccaa tggcgcaacg tcatccttgg 198661 cgacacacct gtttgctgat ttagatgcag atgtttctac aatggggact tccccgaacg 198721 gattaaacat taatgacggc gtcggttcga ctcatcccga agcgctcagc gcgtttgtca 198781 aagagaaaaa cgcggatctc ggtcttgcgt tcgacggtga cggcgaccgc ctgattgctg 198841 tcgatgaaaa aggaaatatt gtagacggcg accaaatcat gtacatatgc tcaaaacatc 198901 tgaaatcaga gggccgttta aaggatgata cagtggtttc aaccgtgatg agcaacctcg 198961 gcttctataa ggcgctcgaa aaagaaggca tcaaaagcgt gcagacagct gtcggcgacc 199021 gctacgtagt agaagcaatg aaaaaagacg gctacaacgt cggcggagag cagtcaggac 199081 atcttatttt ccttgattac aacacgacag gggacggatt attgtctgct attatgctga 199141 tgaacacttt aaaagcaaca ggcaagccgc tgtcagagct tgcagctgaa atgcagaagt 199201 tcccgcagct gttagtcaat gtgagagtga ctgataaata taaagttgaa gaaaatgaaa 199261 aagtaaaagc agttatttct gaagttgaaa aagaaatgaa cggcgacggc cggattttgg 199321 tgcgcccttc aggaactgaa ccgctcgtcc gtgtcatggc tgaagcgaag acgaaagagc 199381 tgtgcgatga gtatgtcaat cgcattgttg aagtcgtccg gtcagaaatg ggattagagt 199441 aacgaagtct attatcagag agtgaacaag acaagcgagg tttacataag ataattgtga 199501 gacatacggc aaagttgctt aaaaaacaat tgaccgttta tgccacatgt tgtaaaatca 199561 agcttgtctt gttcttattt tctcaatagg aaaagaagac gggattattg ctttacctat 199621 aattatagcg cccgaactaa gcgcccggaa aaaggcttag ttgacgagga tggaggttat 199681 cgaattttcg gcggatgcct cccggctgag tgtgcagatc acagccgtaa ggatttcttc 199741 aaaccaaggg ggtgactcct tgaacaaaga gaaatcacat gatcttccaa aaaacatgta 199801 ggaggggacg attgaaagtc cccttgaaat ttgactttct tcgtctcctt ttacaatctt 199861 aggaggaaga aaaatatgtg tggaatcgta ggttatatcg gtcagcttga tgcgaaggaa 199921 attttattaa aagggttaga gaagcttgag tatcgcggtt atgactctgc tggtattgct 199981 gttgccaacg aacagggaat ccatgtgttc aaagaaaaag gacgcattgc agatcttcgt 200041 gaagttgtgg atgccaatgt agaagcgaaa gccggaattg ggcatactcg ctgggcgaca 200101 cacggcgaac caagctatct gaacgctcac ccgcatcaaa gcgcactggg ccgctttaca 200161 cttgttcaca acggcgtgat cgagaactat gttcagctga agcaagagta tttgcaagat 200221 gtagagctca aaagtgacac cgatacagaa gtagtcgttc aagtaatcga gcaattcgtc 200281 aatggaggac ttgagacaga agaagcgttc cgcaaaacac ttacactgtt aaaaggctct 200341 tatgcaattg ctttattcga taacgacaac agagaaacga tttttgtagc gaaaaacaaa 200401 agccctctat tagtaggtct tggagataca ttcaacgtcg tagcatctga tgcgatggcg 200461 atgcttcaag taaccaacga atacgtagag ctgatggata aagaaatggt tatcgtcact 200521 gatgaccaag ttgtcatcaa aaaccttgat ggtgacgtga ttacacgtgc gtcttatatt 200581 gctgagcttg atgccagtga tatcgaaaaa ggcacgtacc ctcactacat gttgaaagaa 200641 acggatgagc agcctgttgt tatgcgcaaa atcatccaaa cgtatcaaga tgaaaacggc 200701 aagctgtctg tgcctggcga tatcgctgcc gctgtagcgg aagcggaccg catctatatc 200761 attggctgcg gaacaagcta ccatgcagga cttgtcggta aacaatatat tgaaatgtgg 200821 gcaaacgtgc cggttgaagt gcatgtagcg agtgaattct cctacaacat gccgcttctg 200881 tctaagaaac cgctcttcat tttcctttct caaagcggag aaacagcaga cagccgcgcg 200941 gtactcgttc aagtcaaagc gctcggacac aaagccctga caatcacaaa cgtacctgga 201001 tcaacgcttt ctcgtgaagc tgactataca ttgctgcttc atgcaggccc tgagatcgct 201061 gttgcgtcaa cgaaagcata cactgcacaa atcgcagttc tggcggttct tgcttctgtg 201121 gctgctgaca aaaatggcat caatatcgga tttgacctcg tcaaagaact cggtatcgct 201181 gcaaacgcaa tggaagctct atgcgaccag aaagacgaaa tggaaatgat cgctcgtgaa 201241 tacctgactg tatccagaaa tgctttcttc atcggacgcg gccttgacta cttcgtatgt 201301 gtcgaaggcg cactgaagct gaaagagatt tcttacatcc aggcagaagg ttttgccggc 201361 ggtgagctaa agcacggaac gattgccttg atcgaacaag gaacaccagt attcgcactg 201421 gcaactcaag agcatgtaaa cctaagcatc cgcggaaacg tcaaagaagt tgctgctcgc 201481 ggagcaaaca catgcatcat ctcactgaaa ggcctagacg atgcggatga cagattcgta 201541 ttgccggaag taaacccagc gcttgctccg ttggtatctg ttgttccatt gcagctgatc 201601 gcttactatg ctgcactgca tcgcggctgt gatgtggata aacctcgtaa ccttgcgaag 201661 agtgttactg tggagtaata attaattaac ccctttggat aagaaggtct tcacatgtgc 201721 tgctaggctc caaatgtaca cctttccgta agggcaaagt caaatgtgaa aaaaaactgt 201781 tccaaagtta atcagaaatt tattttcata ttgtatcctt cggtatcaag tgaaaggagc 201841 atcatatgaa aacattatgg aaagtcctca aaattgtttt tgtcagcttg gctgctttgg 201901 ttttgcttgt atccgtctcg gtatttattt atcaccattt ccagctaaat aaggaggcgg 201961 cactgctgaa aggtaaaggc acagtagtcg atgttgacgg taaaaagatg aatgtgtatc 202021 aagagggaag cgggaaggat acgtttgtgt ttatgtccgg ttcgggtatt gctgcgcctg 202081 cttatgaaat gaaggggctg tacagcaagt tttcaaaaga aaataagatt gctgttgtag 202141 atcgggcagg ttatggatac agtgaagtgt ctcacgatga cagagatatt gatacggtat 202201 tggaacagac gaggaaagcg cttatgaaaa gcggaaataa gcctccttat attttaatgc 202261 ctcattcgat atccgggatt gaagcgatgt attgggcaca gaaatatcct aaggaaatca 202321 aggccattat tgcgatggat attggattgc cccagcagta cgtcacgtat aaattgagcg 202381 gagttgaccg attgaaagtg agagggttcc acctgttaac ctcgattggt tttcatcggt 202441 ttataccttc cgctgtatat aatcctgagg tgattcgaca gtcgttttta actgatgaag 202501 aaaaagaaat ctataaagcc attaacttta agcaattttt taatgcagat atggagcatg 202561 agcttttaca gtcttaccaa aacggcagca aatctgtgaa tctgcctgcg ccaaaggaaa 202621 ctcccgtctt gattttagat gcagtctctg accaaaatag acattcaaag tatgctatac 202681 aaaaccgaaa agactatgaa gcgtttgcgg ctcaattcaa tactgccgat ataaaggaac 202741 tgaggggaac acacagtatt tatttatatc agcctgatca aatatataaa ctgtccatgg 202801 agtttatgag aaaggttcgc taggatgaag ggttatcgta ttttaatcgt tgaggacgat 202861 gtgatgattg gtgatttgct gcaaaagatt ttgcagcgcg agggatatcg tgtgatatgg 202921 aaaacagatg gagcggatgt gctttcggtg attcagaagg tggatttggt cattatggat 202981 gtgatgctgc cgggtgaaga cgggtatcaa atgtctgcaa aaatcaaaaa gctggggctg 203041 ggcattccgg ttatttttct ctcagcccgc aatgacatgg acagcaagct tcaaggtttg 203101 cagatcggcg aggattatat ggtaaagccc tttgatccga gagagctgct attaagaatg 203161 cggaatatgc ttgagcatca ttatgggacc tttacgcaaa tcaaacattt gtatattgat 203221 gcggtaacga aaaaagtgtt caatgaaagc ctgcatgatg aggtattatt tactgcgatt 203281 gagcggaaaa ttttctttta tttatatgaa aatagagaca gtatcctgac aaaggaacat 203341 ttctttgaat atctatggca gctcgaagat agaaacccga atattgtcaa tgtgcatatt 203401 aaaaaaatta gagctaaaat caatgatcaa gcgggtgaga tgattgaaaa tatatatgga 203461 gaagggtatc ggctgaatac cgttgtgaag aaatgaagct caagacaaaa tatcagttgt 203521 tattgtttac ggccgtcatt agtgttccga tgctattgct ggcggtcagt gttttgatgt 203581 cggtgattta tgacagcatg tttaaaccga tgaatcatgg tatgcccttt cacaggtcgt 203641 ttgcataccc ggcaatgatc gttgtatttt tgatatcact cttattgtta gcttttttat 203701 tttcaaagtc gattcattct ctgttgcata aaatcaatct attaaatcaa accattcggc 203761 atttggcgag tgatcaaagg gtgcccgata aaattgaagt gaagcgtgct gatgaaatcg 203821 gggaactgat caagtcggtc aatttgttaa ttgaacggac gacatatcgt gaactggagc 203881 tgagacagca ggaggaaatc aaaaaggagc ttttgcaaaa actgcggcat gacattaata 203941 cacctttaac ggctctcagg ctgcagttat tttatttgga agaccaatgt catggtcagg 204001 ctgtattcga atcattgtat cagcaaatcg aatatatctc ggaattaact aatgaattca 204061 atctatattc cgctgagacg ctggaaagct cttatattgt aaatgaagaa gtgcgtctaa 204121 acgagctatt agaaacagcg gtgaaaaagt gggattattt atacagtatg agtgggattg 204181 agctgcacta taagccggca gatcaagatg tgatatggat gagcaacacg ttatggatgg 204241 aaaggctgtt tgataatatt tttcaaaata cgttaaggca ttcaaaagct aaaaagatgg 204301 aagtcacgat tgaacatggc gatgttttta ttcgtgatga cggtattgga tttgatcgga 204361 atgagagcag tgagggactt gggttaaaga ttattgagga tacatgcagg ctgcttgcga 204421 ttacttatga gctgcataca aatgataacg gaacggggtt cttgttttca aaagagtgac 204481 cccgctgatg tttttctttc tcctataaaa tttatataat agggagaaag aaatggggtg 204541 aacatcatat gtttaaaaaa atcatcaaaa cgattaagta cctctcaagc agttctagtg 204601 accgatatcg cagacaccgg cattacagca gcagccggcg cagacattat cgcagctaca 204661 gcagcagttc gggcaaaaga agacactacg accgttatgg cggcagtcat cgttacaaac 204721 gccggagcta cagcagcagt taatccaaaa aaagttcttg ttccgctttt gggacaaggg 204781 tttttttatg tgaccgattg aatggcccgg tttagatcct cgcgaatgga agcggtgtgc 204841 tgatactctt cctcaatgcc caataatctt ttcagcagca aggttacttc ctttgtcagt 204901 gttaattcct ccagccaagt gccgtttttc ttcttttttc ctttatattg agagtacagc 204961 aagaataaca gcgtttctcc gagatcgaag aagtcatcct gttttcgtac ctttatttcc 205021 tccatttctt caggagtcaa ttgtttggca aggccgaaat cgatgaggca gagcctgcca 205081 tcattgatga tgatattagg cgttctgatg tcgctgtgga agataaggcg atcatgcagg 205141 tattctataa tctcaagcag ctgcgaaatc agttgtaacg ccataagctc tgtgaacggc 205201 tgttttcgaa aaaataataa ttcttctata ttctctccct caatgaactg catgacataa 205261 taagcctgtc cgtctatgat gaattcatct atgaagcccg gaatttgcgg gtggtgaatg 205321 tttttgagca gttttatttc ctgctggaat cggactttct ctttttcctt tttggctttt 205381 gtcggccgaa gctgttttaa gacataaggt gtttgagcta ggatatcggt gcacaaataa 205441 accaaaccgt agcctcccat accgaggcac tcttcgattt tgtattgatg atttaagata 205501 acgccgttct ttagagggcg gtcaaatagc agttttttta gaagttttaa tgccatgtct 205561 gcacttccct tggttgtact gactatagtt taccttctag acggagaata aaaaagagcc 205621 ggataaccgg ctcggtataa gttaaaactg ctttgtcacg tcgtattcat aatctatttt 205681 tgcttttacg ttgctcatcg tcgatctggc tgtcgctaat gtattatatt taaaactcca 205741 tacctttgcc acactgagtt gatccgacaa agagatatca taagaccctg aagtcgagct 205801 gtttacaagg gcacggctcc attcgttatt ttcgcttgtc atgatcagat ggcgtgtatt 205861 tccctggctt ggtgtttgag tggcggttgt ttgaactctg gttacaatgg catcacgcgg 205921 tatcccagat tggtttgtta aatcaacctt gatcacgctg gagtcagaac ctgaggggct 205981 aaggcttgta tttcctttat tttcagcaac gccgctgaat tggaacgttc cgctgcctga 206041 tttgattcgg tcttcaattg aaagcgtaaa gtacatgttt ccagtatagg tgcctcgtga 206101 cactttcaca tagaaggtat ccgtcgtgtt ttgggcgtct gcatttgcat aaataaaaga 206161 agaaaacgta ttagggttaa taacttctgt cccttgagaa acaggtattc tgttcttgtc 206221 ataaatttca attttcatcc ctgtatacgc gctctggtat gtactcctca tgtatacttt 206281 ttctccctta ttagccgtaa aagtgaaata ggcttcatct tgaccagctt ccagtattgt 206341 tgtatcgata tttttatatt tccaataacc gatcggcatt gcggtatcaa atgaattgtt 206401 tcctgtgata gcagtgactc cgacagctga tgccgaatac gtaaaggtag ataagacaga 206461 aagcataaca gcgaattgaa taagccattt tttcaccatg caaacaacct ccttttattt 206521 ccatcataca taataacgat ttaggtgtaa ataaatgttt tttgaggtta atatatacat 206581 tatattcgcc gataaaaaag aataagagag aatactcggg agggaattca atgcgtctga 206641 atcggcaatt tatccgcact cagctgattg cacagaacat attgagcaag aatgcgcctg 206701 ccaaacggga gaatgcgact gaaaatccag cggcagttct ggaaaaggca tatagcaggc 206761 ttaagtcaca atcttcaact gggggaatca atcagttcaa ttattctaaa accagcgtgt 206821 cgggaaacag cgggacgttc agcaaagtgt atcaatcagc gaatgatcga acagtgacag 206881 acacagggga agaaacagtg attcaatccc aaaaccccta tgaatctgag agtgatatca 206941 gaatcaaaat actagatgaa aaatacagca ggatgaatgc gattaataaa acaaagtctg 207001 atccattagg ctatattaag gataagtacc aaaattcaaa gtctccttat ttcagaagtg 207061 atctgtcagc tgcagaaaga caggccgctt acgataatga aacagaatgg ttattcaaag 207121 ggaaggcgca aaactataac cttcaggatg ctgtgtttcg gaatgtcaca tttcatgggg 207181 aagtggaagc tgagaatgaa aaggtgtatc agcggggaca ggttaaccag cagctgcaag 207241 tactgttgaa tcgaaaccat attcatattc cagaggggac agagctgacg tttacaatca 207301 caccgattga ctatcaggtg cgggtaagcg ggacagacga tcaggatctg atcaagcaaa 207361 ttgagcaagt gctgcaatct ggagacaaca gcaaagaact atttttacac atcatgaaaa 207421 gtcaaagcag tgattcagca caattttccg aagaggccta taaaaagtat caggcagctc 207481 gtgagatgta tgaagttaca ggctaccatt tgaaggattt agaagtgatt gatgggcggt 207541 acgtcacgcc tgagggacgt gacttaatgg atgtatataa ggaagagctt gaaaaagatc 207601 cagtgcagaa acaaacggct tcttatgcta tatcttacta tcgttcagag ctcagtaaaa 207661 tcgcggaagc cgggtataat gccattccgg atttcatcct atcaattgat tacagcaatg 207721 gatctctgag agatgtggga caaagcaaga gctatgggac cggagatacc gggtggcttg 207781 aagcattaaa gcgtcaaacg ggtgtgaatt attaggtaag ctgttcatgt aggacagctt 207841 attttttatg agaatctaag gggtgaatta atcccaatat tcaaataatt ttattatttt 207901 tatataaaag attttaaaag aagtgaacga ttcaaaactc tgaacaaagg tgtttacctg 207961 aaaaaaacaa ttgtattttc cagagaaatt tattatgatg aaataagtaa tttaggagat 208021 tatataacaa ttttaagttt gaattttctg attgttatca ctgattcatg tgaaggcaag 208081 caggtctgct gttttctcat ttatgagtat tttgttagga ggaggaagag gagtggcaaa 208141 taaagaatta aagaggggcc tgggcgcgcg ccatattcag atgatcgcct tgggcggtac 208201 aatcggtgtt ggcttgttta tgggttctgc cagcacgatt tcatggactg gcccatctgt 208261 ccttctggct tatgcaatat gcggaatttt tatctttttt attatgcgtg cgatgggtga 208321 aatgctgtat gtcgagccga gcacaggttc ttttgcgacg ttcggccatc aatatattca 208381 tccgatggca ggttatataa cagcatggag caactggttc cagtggatta tcgtcggcat 208441 gtcagaaatt atcgctgtcg gttcttatac gaagtattgg ttcccggatt tgcctgcttg 208501 gatacctggt atcgtggcaa tggtgattct tggtgcggcg aatttaattt ctgttaagtc 208561 gtttggggaa tttgagtttt ggtttgcgat gattaaaatc gtgacgatta tcttgatgat 208621 tattgcggga atcggaatta ttttcttcgg ttttggcaat ggcggagatg cgatcggttt 208681 gtcgaacctg tggtctcacg ggggcttctt tgcaggaggt ttctcaggtt tcttctttgc 208741 actgtctctt gtcattgcag cctatcaagg agttgagctg atcgggatta cagcgggtga 208801 agcgaaggac ccgcaaaaca cgctaagaaa tgcgattcaa agtattatct ggcgtatttt 208861 gattttctac attggcgcta tttttgtgat cgtgacggtg tatccttggg atgagctcaa 208921 ctcactcgga agtccgtttg tgtctacgtt ctcgaaaatt ggaattacgg cagcggccgg 208981 cattattaac tttgtcgtga ttactgcggc aatgtccggc tgtaacagcg gtattttcag 209041 cgcgggccgc atgctgtata cactgggtgt caatggacaa gcaccgaaat tctttaagaa 209101 gatttcacgc aatggtgtgc cgctgtatgg cacaattgcg gtgctgatcg gtttggctgt 209161 cggcgttgta ctgaactata tcgcgccgcc gaagatcttt gtctatgtat acagcgcaag 209221 cgtgctccca gggatgattc cttggtttat cattttgatc agccatatcg gattcagaaa 209281 agcgaagggt gctgcattag ataaacatcc attcaaaatg ccgtttgctc cttttacaaa 209341 ctatttgacg attgctttct tgctgatggt tctggttggc atgtggttta acgatgatac 209401 tcgtatctcc ctgattgtag gcgtgatttt cttagcgctt gtggtcatta gttattatgt 209461 gtttgggatt ggcaaacgca cgcaggccaa tttgacaaaa agcgaacaag cagctgaata 209521 acgataaaaa agagacattc acggatgtct ctttttttat ttttcgcgta tggattttcc 209581 ctattttagc aagctatagg gtaaagatag cagaaggaaa ggtgttcata aaatggatgt 209641 tacactcggt tatttgcgcg aatcactttc gaatcatcta gaaaatgaag tctgccagcg 209701 tatttgcaag aagatgctgg cgaagcgtta tgcaaatgaa gaggaatttg taaaagactt 209761 agatgataat gaaatgtctt ttttgaacca tgtattagaa aaagaaatta agtatgccca 209821 gaatgaacag gatcaaaaac gggccaagga attaaacgag gtgtatgaat tactgctttg 209881 agaaaggcgg gtaagaaatg ggagcaattg aacgaagcgg atatacattt cagccggagt 209941 ttagcgttgt ccgtcaaaac ggagccatcc atgtgtacca tcaaggagaa tttgtggaag 210001 aaatcgaatt tgaatttaac ggggaatatc ccgatcatga tttgattgaa gagcttgtga 210061 atcattattg ttttgagcat gagatttaga gccctgccgt gcagggctct tttatttagg 210121 atgtaatcag gccatacttt ttcaggatat ccacggtgat gtttttggct tttgtgccgg 210181 aatcatcgac attggtgaca aagacataag agccatgctc tgttttgatg aatccgacaa 210241 accatcctaa tcccatatca gtcaggcggg ttccggtttt cccgtagagc gtgtaatgat 210301 cgccttcctc ttgaatcatc atgcgcttga cgattttcat caccggcttg tcaaatggaa 210361 gctcctcttt agccagtttc tccaaaaaag tttcttgttc cagcggagat attgtgagcg 210421 agctttgcag ccaaaactgg tcgattcccc cgctgatatc ctcgttgccg taagatagag 210481 tatgaagcca tgttttcatt ctttcctcgc cgatatctct cgctaatgcc tgataatacc 210541 agattgcgga ttcgcgcatg gccgagccaa gcgtatggtc gcggttccat gattcgaatt 210601 cacgcttgac cccgtcccat cgtttaacat cgtattcatc tcttacagct ttgacctgca 210661 aaccgattaa agcgttcacg actttaaagg tggattgcgg agtttgtctt tgatttgccc 210721 gttttctgtt atagacaaat gtctgatcct tttgtaaatc gtgaagaatg aaggttccat 210781 ccgtatcctt gaattcatca tcgacattca ttttgctgac attcaagtgt ttttcatgag 210841 cagatgatgc tgcgtggacg gagaagccgc cgatccctgc aatactcagc acaagcacaa 210901 catatatcca ttttttcatt ttgttctccc cttcgttttg attaactacc ttttctctct 210961 ttcgtttgtt cttcctttaa aaaataatca aaaagcgctt aaatttggtt ttgcaaacaa 211021 atactgttac tgggtttata gtcggaagat aacgtgaaaa tagagggtaa aaaggaaggc 211081 agggtaagcg gatgaatgag cagattccac atgacaaaag tctcgataac agtctgacac 211141 tgctgaagga agggtattta tttattaaaa acagaacaga gcgctacaat tcagatctgt 211201 ttcaggcccg tttgttggga aaaaacttta tttgcatgac tggcgctgag gcggcgaagg 211261 tgttttatga tacggatcga ttccagcggc agaacgcttt gcctaagcgg gtgcagaaat 211321 cgctgtttgg tgttaatgcg attcagggaa tggatggcag cgcgcatatc catcggaaga 211381 tgctttttct gtcattgatg acaccgccgc atcaaaaacg tttggctgag ttgatgacag 211441 aggagtggaa agcagcagtc acaagatggg agaaggcaga tgaggttgtg ttatttgaag 211501 aagcaaaaga aatcctgtgc cgggtagcgt gctattgggc aggtgttccg ttgaaggaaa 211561 cggaagtcaa agagagagcg gatgacttca ttgacatggt cgacgcgttc ggtgctgtgg 211621 gaccgcggca ttggaaagga agaagagcaa ggccgcgtgc ggaagagtgg attgaagtca 211681 tgattgaaga tgctcgtgcc ggcttgctga aaacgacttc cggaacagcg ctgcatgaaa 211741 tggcttttca cacacaagaa gatggaagcc agctggattc ccgcatggca gccattgagc 211801 tgattaatgt actgcggcct attgtcgcca tttcttactt tctggtgttt tcagctttgg 211861 cgcttcatga gcatccgaag tataaggaat ggctgcggtc tggaaacagc cgggaaagag 211921 aaatgtttgt gcaggaggtc cgcagatatt atccgttcgg cccgttttta ggggcgcttg 211981 tcaaaaaaga ttttgtatgg aataactgtg agtttaagaa gggcacatcg gtgctgcttg 212041 atttatatgg aacgaaccac gaccctcgtc tatgggatca tcccgatgaa ttccggccgg 212101 aacgatttgc ggagcgggaa gaaaatctgt ttgatatgat tcctcaaggc ggggggcacg 212161 ccgagaaagg ccaccgctgt ccaggggaag gcattacaat tgaagtcatg aaagcgagcc 212221 tggatttcct cgtccatcag attgaatacg atgttccgga acaatcactg cattacagtc 212281 tcgccagaat gccatcattg cctgaaagcg gcttcgtaat gagcggaatc agacgaaaaa 212341 gttaaattaa aaagctctct tcctttatcg aagagagctt tttgattact tctttttttc 212401 atcgtagtat tggacgggat acatggagcc ttctgatacc attttgttgt cctcgatatc 212461 ttgcgggtcc gggtggccgg ctttatcaac tgggaacgtt tccatgtctg gctgttttgt 212521 tattttcatc ttcatgctgt gaatgaattc tcttgccttt tggcgatttg acgggtcttt 212581 taatagataa gaagtgatgc cgacagttga aacagcgaga cctgaaagta acagcttttg 212641 tttcatggtg atactccttt ctattttaag aatagtgttt cctgtatcat tcccgttttg 212701 gaaattgcta aacctgttgt gtttttatca ttggaattaa cagtaaattc catttaagaa 212761 gaaactagtg acttcattcc tgtattggaa ggtaatatac attgacttat tatagatttc 212821 agtcaaaatt cgataaatat tgacaaagta aagtaatcag aataataata taattagcaa 212881 gagaatgtca tcatacatga aaggtgttta cgatatgaat caattgcatc gaagaatggg 212941 aacgttttcc ctcatgatgg tcgggctcgg gtcgatgatc ggttcaggct ggctgttcgg 213001 ggcttggcgt gcggctcaaa tagcaggacc agctgctatt atttcatggg ttattggaat 213061 ggtcgtcatt ttatttattg ctctttctta tagtgaacta ggttctatgt tccctgaagc 213121 ggggggaatg gtcaaataca cgcaatattc acacggttcg tttatcggtt ttattgcggg 213181 ctgggccaac tggattgcga ttgtgtccgt cattccggtt gaagcggtgg cctccgttca 213241 atatatgagt tcttggcctt gggaatgggc gaaatggaca agcggtttgg tgaagaatgg 213301 aacgctgact ggggaaggac tagcgtttgc ctctgtattg cttctcattt attttctgct 213361 gaactactgg acagtcaatc tattttcgaa agcgaattca ttaattacga tttttaaaat 213421 tattattccg ggtcttacga ttggagcttt gctgtttgtc ggattccacg gagaaaactt 213481 tactggcggt caaagcattg cgccgaatgg ctgggcaagt gtgctgacgg cggttgccac 213541 ttccggtatc gtttttgcgt ttaatggttt ccaaagcccg attaatatgg cgggtgaagc 213601 aaaaaatccg gggaaatcaa tcccgattgc ggttgttggc tctctttttg ttgcgacagt 213661 gatttatgtc ctgctgcaga tcgccttcat tggagctgtg aatccttctg atattgctca 213721 cggctggagc catctgaatt ttaattctcc ttttgctgat ctggcgattg cgctgaatat 213781 taactggctt gttattgtgt tatatgcaga tgcatttgta tcaccgtctg gaacggggat 213841 tacgtatacg gcgacaacgt cccgaatgat ttacggaatg gaaaaaaaca aatacatgcc 213901 gagtatattc gggaagcttc atccgattta cggcgttccg cgacaagcaa tgttctttaa 213961 cttgattgtt tcgttcatct ttttgttcct gttcagagga tggggcgtat tagcggaaat 214021 tatttctgtt gctacgttaa tttcttatat caccggcccg atcacagtga tgacattgag 214081 acggacgggg aaagacctgt acaggcctct tcgtttaaaa ggcttaaatg tgattgctcc 214141 gcttggattt atctttgcgt cactggtgct gtattgggcg cgctggccgt taacaggaca 214201 ggttctgttt attatcctga tcggtcttcc gatttatttc tattatcagg cgaaggcgaa 214261 atggaaaggg tttggccgga actttaaagc cggcgtctgg atggtgtttt atctgctggc 214321 catgatggtt atttcttatt tgggcagtga taaattcggc ggcctgaatg tcattcatta 214381 tggctgggat atggttctga ttgcgatggt atcccttgta ttctatgtgt gggcgctgaa 214441 gagcggctac cagacagaat acttaaagga tgcgaaagag ataaattctc agctgcttaa 214501 tggacagtca gaagctgctg ccggaaaaga ataaaatata gaagaaaacc ttgcgatagt 214561 tgtcgcaagg ttttttgctt ttaataaccc ttttttactt tgtggaaaag atcaggatag 214621 ttggtgaaca ctcctgttac gccccaatca agcaggcgat gcatatcagc ttcattattg 214681 actgtgtaag gatgaagcag gaggccgtgg ctgcggatca tacggacgtt ttcttgattt 214741 aaagctttat aatccgggcc cgcaccgaca gcgtatgttt tgatttcttc cagggcagca 214801 tctgtcattg acgccatttg tttggcttcc agcaattgaa cggtcggcag gtttggctgt 214861 aattgatgga cttttaccag gctttctttg ctgaacgatt gaatgatcac ctggcctggc 214921 ttagaatgct ttcccagtaa tttatgtttc tgcaaagaag cgatcagttt ttcttccata 214981 cctgggtagg tgtcaggcga ttttgtttca atgtagtagt tcgcgtgctt tccgaaacgg 215041 tctaatacct cttctaatgt aggaacttta aggccgacgt actgcggctt tgctttttcc 215101 ggataggctt cattaaacca agaaccggcg tcaagcttct taatgtctgc gagcgtatgg 215161 tctttcaccc aacccattcc gtttgtggtg cggtccagtt tttcgtcatg catgacaatc 215221 aattttccgt cttttgtcat ttgcagatcc aattcaataa aatcagcttt cattttctga 215281 gcggtttcgt aagacagaat cgtgtgctca ggcacatatc cagaagcccc tctgtgcgcg 215341 acggtcagga tacggtcagg tgacagcagg tttccttttg acgctgccga cactggcgtt 215401 accataaatg agagtaagcc cagcgacaga acaaacaagg ccagtattct attttttctc 215461 atgatttctc ctccttatag ataagcacta cctgtctttc ataataaaaa acggatgtaa 215521 acggcgtgtt ggaaaactat taatctttta tgtgtctttc ttaaacatgc tctgcccgtt 215581 ttcctgtatt ccacgtcaaa gccaagaaga cgatggcaag aatgcaggat gagatcagca 215641 tgataaagcc gccgttccag ttaaaacggt ccacgacaaa gcccataatg gcgtttgcga 215701 aggcggatcc gccgatgtat ccgaaaaatc cggtcaaacc ggctgcagtt ccggctgctt 215761 ttttcggtgc taggtcaatt gcttgaaggc cgatcagcat aacaggtccg tagattaaga 215821 agccaatgct gatcagggcg atattgtcca cgagcggatt gccggccgga ttcagccagt 215881 acaccaatac ggcaatgaaa acacccgcca taaacaaaac gcctgccggt gcccggcggc 215941 ttttgaagaa tcggtcactg atccagccgc acaagatcgt tcccggtatg cctgcgtatt 216001 cgtaaagaaa atacgaccag cgtgagtctt caggagaaaa gcctttggct tctgttaagt 216061 aagtaggcgc ccagtcaacc acgccgtatc gcacgaaata aacaaataca ttggcaaaag 216121 cgatgtacca aagaaatttg ttgttcagca catattgaaa aagaatttct tttgttgtta 216181 attctttttc ctgattttta aaagcgtgtt ttggatagtc attccgatac tcttcaattg 216241 gcgggagtcc gcaggattga ggcgtatcac gaaccaataa aacaattaaa aatgaaatga 216301 taatggcgat gatggcaggg aagaaaaaca cgcttttcca agtgacgaac atcgcgatcc 216361 caagagtgac aagcggagca agaataccgc cgcctatgtt atgggcgaca ttccagatcg 216421 acatttttgt gccgcgttca cttatggaga accaatgggc catcgtcctg ccgcatggcg 216481 gccagcccat tccttgaaac catccgttga taaacataaa aataaacatg atggtgacgc 216541 tcgaagtcac ccaaggcatt gaaacgaata gaatattaac gattgctgat aaaaataggc 216601 ctgtcgccag aaaatatctc ggattacagc ggtcagacac cattcccatg atgaatttgc 216661 tgaagccgta cgcaatggac acagcggcca gcaccaaacc cagttctgtt ttcgaaaatc 216721 cctgttcctg cagataagga atggcaaagg caaagttttt ccgcagcagg tagtagcctg 216781 cgtagccaat gaaaatacca atgaatactt gcagtctgag ccgtttgtat gccgcatcca 216841 tctttgaatc atccagtctc tcaatatgag gagccggttt aaatatatta agcattaata 216901 attatccccc tttgctgttt gtgctggatg tgtggcgtgc ctcctttccc gaaaaacaaa 216961 aagagccaga aaacacccct tgtcaaaagg ggttggattc ctggctctcc tcatctccat 217021 ccaagctatt aacttatcat gatagcgctt tcttaaatta tcatagtccg gagcgaatgt 217081 aaacgggtaa ttttcaaatt gggccttagg gaagtgaata ttatcctttt actaaatgca 217141 attatatttt tttactagta acataaaaat ctggagggag gctgtttaaa gatggatgaa 217201 ttagatatcg cattctttat tttaccgtta ggaattatgc tgctatcgat tgtcgggacc 217261 tgtatttgta aaaacccgta tctgatgcca atgcttagtt tggtgatttc tcttgtgctc 217321 acctttacca tttttaatca atcatttttg ggatgggctg ttgtctatag cttggtttct 217381 ctggctttat cctatatcac attgattgtg gtaaggaaaa ggaaggaatc aggaaattaa 217441 aaagacctca ctttctaaca tatcgttgac taaagcaact atatgtgatt ataattgctt 217501 tagtcaacga tattagaaag tgggaattga tttgaaaaca agagaatcat ctgtcgggtt 217561 aaaattcaga aagttcaatc gattttatac aaacgtcctt ggtttcctta atgagcacat 217621 ttacgacagc ccgttttcct taacagaaac acggatttta tttgagattt ataatacgcc 217681 taattgtacg gcaaaagctc ttcaggataa gctggggctt gaccggggat atgtcagcag 217741 gattgtgaag cagtttgaaa aagaagattt gatttataaa cagaggagca aagatgacgc 217801 ccgccaccat tacatttttg tcacagaaac aggaaaaacg atttataaaa agctggagga 217861 gaaagccaac gaacaagtag aactgatgct gaaggtaatc aaccaaaagg agcagcacaa 217921 gcttgccgag gcgatggcag agattgaagc gatcctttca cagtcgcttt ctgccagagc 217981 atcagagata tcgattagag attattttct ttcggaggat cttcaactcc ttattgagaa 218041 acaaagacaa ttttacgcgg aggctcacgg ttgggatgac acgtttttag cttatcttca 218101 ggagacattt gacgctgaca tcgaaaaaat atggattgcg gaaagcggcg ggaaatttgc 218161 cggctctgtc gggttggtca agcacgatga aaagacagtc cagctcagat ggtttctggt 218221 tgatgcggat tttcggggca gggggcttgg cacgcaattg ctggagcatc tggttgcata 218281 ctgccaagac atgaagtttg accgcatttt cctttggacg gtgagcacga tggctgaggc 218341 tcgtccgctc tataaaaaat ttggattcag gataagtgaa gtaaaacaag aagcgccatt 218401 atggggacag cagctgacag aagaacggtg ggatttggag ctgtcatgaa aagactgcat 218461 tatgcgtgga tcatcgtctc cgtcaccttt ttgatcttat tggcggttca gggggtgcgg 218521 ctgtcgtttg gtgcgtttgt ggagccgtgg gaacggcagt tttcaatcga tagaagcacc 218581 atctcgctga tttcgacggt gagttttatt gtttatggca tatcacagcc tgtgatcggt 218641 cggcttgtgg acaaatgggg tgcccgggct gttttggcat ggagtgcgtt actgacagga 218701 gtcagcattt tcttaacata ccttgtgact tcgccttggc agctgttttt gctttacggg 218761 ctgggtgtct cgcttggagt gggcggagca tcgaatgtgg cggcaagtgt attggtcgtc 218821 aattggttca gcaaaaagcg gggactagcc tttgggatca tggaagcagg ctttggcgcg 218881 gggcaaatgc ttctcgttcc cggctcactc atgttgatcc attggtttag ctggaagctg 218941 acggttgtgg tgttgggact gctgttaatc gtgattgtct ttccggctgc gctgctgatg 219001 ctgcggaaca atccttcaga aaagaataca gagccgatag gcggactggc tgcatcagaa 219061 aaagaaacag cacccaaaac aacagctctt tcagtggccg ggatgtttcg tatgaggcaa 219121 ttctggttct tgatttttcc gtttttgatc tgtggattta cgaccgtggg gctgatggat 219181 acccatttga ttccgttttc tcatgatcat ggcttttcaa cgacagtcac gagtgctgct 219241 gtcagtctgc tagcaggctt taatattgct gggatcttgc tgtccggaat tgtagcggac 219301 cggtggagca gccggaaaat cctgtgcatt ttatatgcgg tgcgggcgct gtcgatcgtg 219361 attcttattt acagccacga gccctacttg cttttagcct ttgcgattct gtttggatta 219421 gtggactttg caacggtagc accgactcaa atgctcgcca cccagtactt tcaaaactac 219481 tcgatcggcc tcatgattgg ctggctgtca ctcgcccatc agatcggatc ggcactaggt 219541 gcgtatgtgc ccggcgtcat ctacacggta acgggtgagt atacactggc tttttatttg 219601 tcgattggaa tgctcgtgct tgcgagcgta atgaatgtga tgctgaggga gccagctgcg 219661 gttacgcgtg acagtgcggc tgtggtagac aagtgatgag gacaaaggga aagcatctct 219721 gatttcgaga ttattcagag atgctttttt tgtatttttg ttctaatacg aagtcgatca 219781 taccgactat gcgggcgttt tcggattttt gtttgaagcg ttcagaaatt tgaacttttc 219841 ttgaaaatgg ggaaacaata aaaacccaaa aaaggccgat caaggcaaaa aacatttgta 219901 cagctaattc tattaattca ttaaaacgag tgctgaaaaa atagaagtat aacgttatta 219961 atgtcacagt acatacgatt ttggcaagtg tgtttgaatg taagcaatgg ttcactaaag 220021 aataccttta attgattcag catgattgaa tcatatttgt ttaggaaaat aagaagttct 220081 ttatcatctt ttttatgttc taaaataaag ttgctgtttc tgtttcttta tatgtatggt 220141 ggtctacatt caatatatac atctcttaaa gtataaaaat tgagtatttc ttagtaagga 220201 tgaaacaaaa ttacatgatt tttttgttat atctttcagt tagaataaaa tctataactc 220261 ctctcattcg caaatattcg gctctctgtg caaagtgcag aacagtatgt aattgtcctt 220321 ttctagatat atttaaaagc tttatcaaat caataaggat tttcaagaaa ataattaata 220381 atagaaagat aaaaatgtgt ggtatgtcaa tgtaattgat ttgtcctgaa aataaagaag 220441 ttgcatagac aacaataata cttccgcaaa acatcaaact catataatgt ggaagggaaa 220501 atggacgagt tgaaaaatat gcttttaatt ggcttagcat agcattatct cttgtatcta 220561 agtagcccaa aagctcttta tcatttttac taattgtaag aacatgattc aatacagcac 220621 taaaattcat tgaatcttca ttatcagagg cagtatgttt attagcctgt atgttttgtt 220681 gatccatttt atatttttta taaagtattg tattaattaa cttgtttttc tcatagaatt 220741 cagatcgttg attaagggat gcttttcctt tgtttttatt tccttttttt atgattttag 220801 tataagtcat aaaaatacaa atgactgtaa aaatagaaaa cactgcaggt gaaatatctg 220861 aaagaatagt attggtgaag acttcttttg cttggatgaa aaggaaagaa gctaaagtca 220921 tagatataaa catgcataaa actgctactt tcacaagaaa ctgaagcgga agagaaggtt 220981 ccgaataata gtgcttcaac tggttgagtg tcagagaatc ttggcgaaaa agataatcta 221041 ttatctcctg ctgattttgc atctgattga tatcatgagc gatgtttttt gttttttcaa 221101 aaactatttg atcatttttc atttttgata aacctccaaa agacgataga taaactaaaa 221161 aaactgcatg agcatatttt aacttatgtt catgcagttt tgtattaaag ttagctagta 221221 taataagcaa aaatggccag taacatagca gataatgcgg tagcgacttt gactccttta 221281 ttgttcgtta aatcactgcc catattccca attagtaaaa gtgcagcaac acctacaaca 221341 gggaataaat attgatcata agacggccaa tctaacgcta attcactctc gggagacgta 221401 actggtactc ccttgtacgt ctttatttta aacgtaatcg tagtcgttag tccagttgtg 221461 acattgtcac cgactggaat atcaggtgta tagattttaa tttgaatgtt taaagattca 221521 gctgttggat ttacataaac ctccaaataa ccgttgcgta ctgataagct cagactattt 221581 aaaaggtttt gataagagtc gatttgtgac gcagtgagag acgtttgagt gtcgcccaat 221641 aaacccgtga tataggcacc tggtttacca tttgtaatgg taattgtgtt tggtgaacct 221701 tcacttggta tggttgccag aagtgaagtt gatagaataa tatccaactc aggtgatgtg 221761 aaaatggttt ctgtcgtatc aaattcaaac atcgcgtttg ccagacttgt tagattttct 221821 aaagctggaa tggtagataa aatgtctgtc agtgtacgca gtcttgcatc atataccgga 221881 tcagacggcg gatttacatt gcttgcacct gagtctcttc ctgaataccc gtctttatca 221941 atcccgatgc ttccagagcc gcttccgatg gttccttcat aaaattgatc aaaggcccag 222001 ttgtttggca tcggatagcc gagattgccg ctaaatcctg ttgacatatt tgccacaaaa 222061 ctatactttg tcagtcctgc ttcagatgta cggatacaaa tgtttcttgg tccgtaaacc 222121 cctatttcat acttaggtgc ggttgaaaat gtctgcattt ttgtaaatgc tgacttaatc 222181 tcttggaaat aaggaatgat tttatcggtc acttcataat cgtatgcatc aaaatcgaca 222241 gcgaaataaa tggtcgtgcc tgacggaaaa cctaatcttc tagcagcaga agcggcacta 222301 tatgcatctc ttgtgccttg gtctttgaca aaataagaag attcatagcc gccgtcttga 222361 taaattggga aaaccttcaa tccggcatca agaataactg caagctcttt agatgtcagg 222421 gctttagatg tgaggccgct gcttgtccgc acatttccgg tcaaatatct gccaaccgtt 222481 ttataaccgt tattccgcag tgtttgagct ttttctgcgg ttataattgt agcagtgtca 222541 caagcagaag cggtgcgagt tgtgtctcct gagcttgata ataaagcttt aatggttggc 222601 atatctgcat aacctgtttg cggcaggcac atgaactctt gaaatgcttt aacagctgaa 222661 acaacaccca caccatattt gccgtcaaac tcaccaggat cgaacgattt tccgttacaa 222721 tagagggcgt actgaacaat taagacaaat cctgttcttg aatcgccggg agttaaagta 222781 gggcacaaac ttgtggtgcc gtttccgaaa aatccattgg caacacttgt gctcatgcct 222841 tcttcttttt gcagggcata aataagagct ttatttgtat cgcggccata cagtccgtca 222901 caaggcatta acccgatata gtcattgtag tctcgattta agttttgttg aatctggcga 222961 attcttgaat cacccccaga caccagctta aaagcgctca tgtctaataa ggctttcata 223021 attaacgtgg tgacaatccc atcctgtgtt gtcagtccgg cagctttttg aaattctttt 223081 accgcatttt ctgttttttc gtaaaagacg cctgtaaaac cgccgggatt aaagccttta 223141 caccataaag ccccttgtaa aataaaattc atgttgcttg gttttgaatc tggagcttgg 223201 cgtttaagag gcttaaataa gcgctgtgtt gtcggcccga agttatcggc tggctctgag 223261 atacccaatt caatttgaag cgcccgagtc agaccgtaga tcgtatccca cccagttttc 223321 ccgctttctt caactgggtt atacccatgt ttgccgctgt acgtatcgtt cagccattgc 223381 tgtgtgatta agaccatttc atcaaccatt tcgattcctc ctttgttaga ttgcgttcat 223441 ttataggtgg caaacgtagg acaaaataaa aaaatggatg ccgttaagca tccattttac 223501 atccgttctc caacagcttc gctttcggtt tcagctctga aatgtagagg cctaaaagtg 223561 taagcgcgcc tcctagaaga gcgatccatg tcatgttttc gtgcagaatc aggacagaag 223621 cggcgatcgt gataaccggg accatgtaaa tatacgcact ggatttgacg gctccgagca 223681 ctccaactga ataattccaa gtggcgaagc acagggcaga agcgccaatc cctaagaaaa 223741 gcatgttgag tatatttgaa gcagatgaaa atcggcttag gtcaaaatgg aagtcgaaca 223801 aaaataaagc gggaaccata aacaataaac catacaaaaa tactctctgt gtcagctcga 223861 tgatgtggta ttcgtaggcg cttaattttt tcatgaatat cgagtatccg ccaaacacga 223921 gagcagcccc ggctgccatg atgtctccga gcggatttag acgcagtacc acattgccgt 223981 taaacgtaat caataaaagc ccgatcagtg ccgagataaa tccaatcaaa aaagtcagac 224041 gcaatttttc gccttcgagc agaaaatggg ccaaaaccgc agtgatcatc ggtataatgg 224101 acacgatcat gccgacattg gaggcgtatg tataggtgag agctatattt tctaatagaa 224161 agtataaggt tacgccaaat aaaccagctc cggcaaacaa cagctcctgc cgccaatttc 224221 tgaacggaat catgttggga cggacgagga taagagcgat aaagcccatc aaaaaccgat 224281 aaaataatat ttccattgga gagaagtcag ccagcagaac ttttgtcgaa ataaaggtcg 224341 tcccccaaat cagaatggtc acaatggctg cgatatgccc cgaagtttct ctttgtatgt 224401 tcatctgtga agctcctttt caaaaatctt catgtattgc ttcggcgtca gccccacctg 224461 ccgtttaaaa aacttcgtca tatgactctg atcgctgaat cctgtctgaa atgccgcatc 224521 aatcggcctt accccttgtt caaggagttt tttggcttga ttaatccgga ttgtttccat 224581 gtagctatta ggggtaatgc ctttttgttt tgtaaatgaa cgcaataaat gatacttgct 224641 ccagcctgtt aattcactca aatcattgag tgtaacattt tcggcataat gctcttctaa 224701 aaattcacaa accattttga cttcgtctga tggttctgga acgctgctaa ggaacgtgac 224761 atctgaataa tggcggatca gctcctctaa tagatgaaga aacagctcct ccttacgcaa 224821 agcttgtttt tcctcggata tcaaaatatg caattcctgc aggctggctg tcagctcatg 224881 gcggaataac acatgctggg agaaataagg gagatgcccg gagccagtaa tctctttcac 224941 cgccttctcc atgatatccg gcatgacatt gatacaccga taatcaagcg tccggccgtc 225001 aatctgttca cagctatgcg tgtcacgggg gttaaagagg agaagatcac ctggattgat 225061 gatatattct tgatcctgac aggccagata ccgttgccct ttttcaataa atccaatcac 225121 ataataatcg tgaaagtggt tcgggaactt ctgcataatt cccttgaagc ggtaggcttc 225181 tatatgaagg tgtgggtcaa gctgcagtgt gcgggtttcg ttttgcatgg gatgcctcct 225241 gtcggtgtgg tggtcttgga ttaagtgtag catgattttg ggggatttct tgtatgatgt 225301 tgctgtttag gaatagagaa agcagaccgt tatttgtctg ctttcgttta agaatttaaa 225361 agattttaac cctcaataat aattttatct tttttaataa aaatttattt ttcaaatatt 225421 tcagttataa tggtttggaa cagataggag gggcaaagat gtatcaatca aagaaggttt 225481 tattgttagg ttcaggtgaa ttaggtaaag aggtagtgat tgaagcccag cgtcttgggg 225541 tacagacggt ggcagttgac agttacgagc atgctccggc gatgcaggtc gcgcataaca 225601 gttatgtcgt tgatatgctg gacccagagc agatcagaac catcattgag aaagaaaatc 225661 cggatttgat tgtgcctgag gttgaggcga ttgcgacgga tgaattgctg aagcttgaag 225721 aggaaggatt tcacgttatc ccgaatgccc gtgcggccaa gctgacgatg gatcgggaag 225781 gcatcagacg acttgcggcg gaaacgcttg gacttgcgac agctggctat gaatttgcga 225841 atacatatga tgaatttata caagcggcag ctcagatcgg ttttccttgt gtcgttaaac 225901 cattgatgag ttcttctgga aaaggccaaa gtgtgtgccg ctctgaagcg gatttagaga 225961 gctgctggga gacggcgatg gaaggcggac gggtgaaaaa cggccgcgtg atcgttgagg 226021 agtttatccc tttcgaatca gaaatcacac tcttaaccgt acgtgcggtt aacggtacgg 226081 cattttgtga gccgatcggt catgtgcaaa aggacgggga ttatatcgaa tcgtggcagc 226141 cgcatgatat gacagagcag caaatagaag aagcgaagca tattgcgaaa acgatcacgg 226201 atgagcttgg cggatacggc ctgtttggtg ttgagctgtt ccttgcgaaa gatagggtat 226261 atttcagtga ggtatctcct cgtccgcatg atacgggtct tgtcacgctg gtgacgcaaa 226321 atttgtcaga atttgcgctg catgtccggg cgattctcgg ctttccgatt acagaaatca 226381 cacagctttc tcctggcgcc agcaggcccc tcaaagcgcc ggaagaatta gcggattaca 226441 ctgttgaagg attggaaaac gcactggcag tcccaaagac tcaagtgcgc gtctttggaa 226501 agccgataac aaaagccgga cgtcgtatgg cagttgcgct ttctgctgct gattcagttg 226561 aaacggcaag agagaatgca aagaaagcgt tggaccagct aattttaaaa tagagtttga 226621 acaggtcttg tcatgggaca aggcctgttt ttttctttct ccgtaaaagt tttatcataa 226681 gaatcagaaa cctgattata atgtaaaagt cttccatcga tacgggtggt tgacactaaa 226741 ggagggagat gacaaaatga aattagttcc aagattcaga aaacaatggt tcgcttactt 226801 aacggttttg tgtttggctt tggcagcagc ggtttctttt ggcgtaccgg caaaagcggc 226861 agagaacccg caaacttctg tatcgaatac cggtaaagaa gctgatgcta cgaaaaacca 226921 aacgtcaaaa gcagatcagg tttccgcccc ttatgaggga accggaaaaa caagtaaatc 226981 gttatacggc ggccaaacgg aactggaaaa aaacattcaa accttacagc cttcgagcat 227041 tatcggaact gatgaacgca ccagaatctc cagcacgaca tcttttccat atagagcaac 227101 cgttcaactg tcaatcaagt atcccaacac ttcaagcact tatggatgta ccggattttt 227161 agtcaatcca aatacagtcg tcacggctgg acattgtgtg tacagccagg atcatggatg 227221 ggcttcgacg ataaccgccg cgccgggccg caatggttcg tcatatccgt acggtactta 227281 ttcaggcacg atgttttact ccgtcaaagg atggacggaa agcaaagaca ccaactatga 227341 ttacggagct attaaattaa acggttctcc tggaaacacg gttggctggt acggctaccg 227401 gactacaaac agcagcagtc ccgtgggcct ttcctcgtca gtgacaggat tcccatgtga 227461 caaaaccttt ggcacgatgt ggtctgatac aaagccgatt cgctccgctg aaacgtataa 227521 gctgacctat acaaccgata cgtacggctg ccaaagcggc tcgcctgttt atcgaaacta 227581 cagtgataca gggcagacag ctattgccat tcacacgaac ggaggatcgt catataactt 227641 gggaacaagg gtgacgaacg atgtattcaa caatattcaa tattgggcaa atcaataaat 227701 acagcaaact agccatattc atgtctattt tgtttttatg cgggtgcagt tcgcagacgc 227761 attcttctca aaaagaaacg actattcctg tcactcttca tgtggaggat gctaaggggc 227821 tgccggtcga aggggttcaa gtgacgattg tcaaagcgcc ctcttcagat gaggagccga 227881 gtacagagat tggcgagata ctcggtaaaa cagacaaaaa cggagatatc aaatgggata 227941 ccggcagaaa aggcgattac tcagtcgcgt tgacgaaggg tgaaacatca gtaacccatc 228001 acatctcgtt aacagaggat aaaaaagatc atgccattcc attagtcttc aaagaatagc 228061 agtttccttg attttaaggg aactgccttt tttatttatt gcaggaaacc aaactatata 228121 ctggaaattt attatgtgag ataataagaa ataggtattt tttcttacga gacaaaaggg 228181 gcgttatcct ttatatcaat caaacccgga ggaaaaagaa gaagatgata caagattcaa 228241 tgcagtttgc cgcggttgaa agtggtctgc gcttttacca ggcatatgat caaagccttt 228301 ctttgtggcc gattgagtcg gaagcattct atgtttctac tcgttttgga aaaacacata 228361 tcattgcaag tgggccaaag gacgcacctt cgctcatttt gcttcacgga ggccttttca 228421 gctctgcgat gtggtatccg aatatcgcag cgtggagcag tcaatttcgt acatatgcgg 228481 tcgatataat aggagacaaa aataaaagta taccatcagc agccatggaa acgagagctg 228541 attttgcaga atggatgaaa gatgtctttg attctcttgg acttgagacg gcacatctgg 228601 ccggcctttc gcttggcggg tcccatatcg tgaatttctt actccgcgcg cctgaaagag 228661 tagagcgggc ggttgttatc agtcccgctg aagcgtttat ttcatttcat ccggatgtct 228721 ataaatacgc tgcagagctt acaggggcaa gaggagctga atcatatatc aagtggatca 228781 caggcgacag ttatgatctg catcctttac tgcaaagaca aattgtggcg ggcgtggaat 228841 ggcaggatga gcaaaggagc ctgaagccga cagaaaacgg ctttccgtac gtgttcacag 228901 accaggaatt gaaatcaata caagtcccgg tacttctgat gttcggtgag cacgaggcta 228961 tgtaccatca gcaaatggcc tttgagcggg cttcggtatt ggtgccggga attcaggctg 229021 aaatcgtaaa gaacgccgga catctgttat ctctggagca gccagagtac gtcaatcaac 229081 gcgtcttgtc ctttttatgc ggggggataa aatagtaagg aacatgaaaa gattggcatt 229141 catttttcaa aaggtaacaa atgttgtata ataatagaat ttgaatgctg ctttttttgg 229201 gagcattcta tgttatcatg cttattggag aaaaattttt cctgtaacgc tattcgatca 229261 ctatcgtcaa ataatataga tggttttaca attggaggtt tggttacact gtgaattaca 229321 tcccctgtat gattacgata ggaaacttca tttgcggatt gctggcgatt cattccttgc 229381 tatatcacaa cattcattca gcagtgcttt ttatttttac aggcatgttc cttgatttct 229441 ttgacgggat ggctgctcgt aagctgaatg ccgtttctga tatggggaga gaactggatt 229501 cgtttgccga tctggttacg tttggggtgg ctccttctat gcttgcttac agtgtcgcgt 229561 tgtataccct gccatttatc gggatcttat gcgcattgac gtacagcatt tgcggaatgc 229621 ttcgcctctc taaatttaac attgaacaaa gcaagctccc gacgtttatc ggtatgccga 229681 ttccgtttgc gggcatgtgt ctcgttattc taagcttcac ctataacccg atccttctgg 229741 caatcggcac ttgcggactc tcatatttga tggtgagtaa aataaaattc cctcatttta 229801 aaaaacatgc ggcagaaaac ctggagtctg ggagatggaa ttagttcagc agctcatagc 229861 ggattacggt tatctcgcta tttttttgat gctggtatta ggaattgtag gattgccgat 229921 tccagatgaa gtgatgatga ccgttgttgg ctatttcacg cataccgatg tattgaatta 229981 tgagctttcg atattgatta gttttgtcgg ggctttgtta ggtatgctga tcagctacat 230041 gattggcaga aaagccggac gcccgtttat cgacaagtac ggcaagtggg tcggcttaaa 230101 agaaaaaaga atgatgaaag tggaaaaatg gatgaagaaa tacggtccat attctcttat 230161 tttaggttat tttattcccg gcgtcagaca tgtgacgtgc tacttttcgg ggatcggcaa 230221 aatggatctg aaaacgtatg ttgcgtttgc tgcaatcggc gcctttttat ggtgctttgt 230281 ttttattaca atcggaaggg ttatagggat tattcatgtt taatacggct gtaaagattc 230341 tgtatcgatc attgatagag ctgacgaatc atcgtctgtc atcctatctg attaaaggat 230401 tttgcgagtc gaaaatcagc aaaccggtca ttccgctttt ctcaaaacat tttcggctga 230461 attgggatga tgtggacggt acggctgctg attacggatc gctgtccgaa ttgttcattc 230521 gacaaataaa tctggagcgg cgccctgtgt caaaagaggc gcatgcggtg gtcagccctg 230581 ttgacggtgt ggttcagacg gtaggaatca tcaacccgaa tcaaaccttt acggtgaagg 230641 gaaaagatta ctcattcgct gagctgaccg gctgtaaaag cgcagaccat caatacaacg 230701 gcggatattt cgtcgtgctg tatttaagcc cgaggcatta tcaccgtttc cattctccga 230761 tcagctgcag gtatcaaaag ctggccgagc tcggaaatcg ctcatacccg gtaaatcaac 230821 taggcttaaa atacgggaaa gatgtgctgt cgaaaaatta tcggtttgtg tacgagctga 230881 atagcggcag ccgaaatgtc ctgatgattc ctgtcggcgc gatgaatatt aattctatcg 230941 tgcagacgaa tacccgtact gaattggaga tcggcgagga gctgggatac ttttcatttg 231001 gctcaaccgt cattttggtt tttgaaaaag acgcgttcca gccgtccgcc catttagcag 231061 aaggccaaga agtccaagtc ggagaactga taggttacga agaataaaaa gaggagcttg 231121 cataaacgca gcgcctcttt ttttgaagaa aggtgagatt catggagaaa caaatcatca 231181 gctggattac agattatcag aacaccggag atgaagccgt cctgcggcaa gtgcgagaag 231241 tgtgctggcc gatcgttgaa gcggttttgc aagagaaagt aatggatgat gaacaagcga 231301 acaatttgcg cgaaaaagga atcgagcggt ttccattcat catcagcaaa taccaagcgg 231361 atgtgcagct tccggttgag acatttttac aaaatacgta tcggttttac tttcatcagg 231421 tgatgagaga atccagctaa agcttctttc aacagagaag cttttttttg ttggcaggaa 231481 aaggaaactt tttctatatc tatctcgtaa tgactagaga acctagcaga aaaggagaga 231541 tagaattgaa acgaatgata gtgagaatga ccctgccgct gctgatcgtt tgtctggcgt 231601 tttcttcttt ttcagcctca gcccgtgctg cttctgaaga aaaatattgg gatcactgga 231661 ttgaacgaca tgcacagcct ctggatgctt ccaatgcttc aaacaaagac cttcgatttc 231721 taaaaaaggt gctgaaggga aaacgaatcg ttcagttagg agaaaccaca cacggtgctg 231781 gcgaaatcaa tgccacaaag gtcagaatga tcaaatacct ccacgaagag ctgggatacg 231841 atgtattggc ctttgaatcc ggctttcctg atacaaatgc atcctacctt aatatggacc 231901 aattaacccc taaaagcacg atgaaaaact ccatttacgc tgtatggcac acagaagatg 231961 tcgtcgaatt gtttgattac atgaaagagc aaaaagagaa aggcgatccg ctgatcctta 232021 ccggttttga tattcaaagc atgaagaatt cattcaatgt agctgcgact caatgggtaa 232081 aagcggtgga ccctgagaaa gcagagttgc tctcccaatc agaaaatgat ttttcaacat 232141 tagtgacaga cagcaatacg tttgatgaat tttcgcaaaa gaaggaaaag cttgtgaaaa 232201 actatcagaa gctgatcaag ttcactaaaa cacatgcttc agagctaaaa gaaaaccttc 232261 caaaagagcc gaaagcttat gagatgttta tgcattctct tcagctgaga attgacgtaa 232321 tggaaacata tatgctggaa gaaatgaaag aaaaactaga ggagtatccg gagaatattg 232381 aggatttttc attctttatg agagaccgca tgatggctga acaatttcag tgggtagccg 232441 acacccttta tccgaaaaag aaaatcattg tctggggcca caattaccat ctacgcaaac 232501 agaatacgaa gatgataaag gactgggtac agctaaacgg ccctaacatg ggtgattatt 232561 tgccggagcg gctgaaaaaa caaacatata cgattggcat ttatgcttac tcaggtgcga 232621 gtcttgatag ctccgataat aagactgtta agccggttac aagcccgccg ccgtctggga 232681 gccttgaagc tttgctgaaa gcggcggacc gaccggctgt ttttgttgat tttctccata 232741 caaaaaacaa gaaaggcact tcgtggatgt ataccccgcg gactgcgctc tattgggggt 232801 acatggaaga gcagatgatc ctgaaggaac aatatgacgg tgtcatttgg ctggagcata 232861 tcacgccctc tgtcattatc aagtgagcgg tgtcccctgt ggtaaacagg ggatttttac 232921 atatcgcaaa aataatcaaa acatataatc cgtgatccat tattctaaaa cagaaaggag 232981 attggagcgt gcaatgtatt atgaaaaagc tgtccagaaa acaatcaatt ggattgaatc 233041 acatttacat gagcaaatat caaacgagga tattgttaac gtttcaagct tttcaaaatt 233101 ccattttcat cggatttttc aaaaagaagt cggcatgtcg gttgcttctt atattcggtt 233161 aagacgtctt gcgaatgcgg cggcagcttt gctttataca gatcatcgta ttatcgatat 233221 tgctttgtat tatcagtttg aatctcaaga agcatttacg aggacgttca aaaagatgta 233281 tcacatgccg ccaggagcat accgaacatt tatgaaacgc tttacttcaa aaaaggagga 233341 atcttacatg gagaaaaaaa tgaaaggctg ggtattgagc gggagccatc cgttccaatt 233401 cgaaatgggg attgaccggg aaaatgtaca tcagggaaaa gcttcagggt atttaaagtc 233461 aacgatggtt caggatatcg gtgaatttgc gacgatgatg cagcaattca aagcagatcg 233521 ctatctagga aaaaggcttc gtctatcaag ttttatcaaa acaaaggggg tgcagcattt 233581 tgcctcactt tggatgcggg ttgacagtgc tgctgatgat gttctccaat ttgataatat 233641 gagcaacaga cctattaccg gaacaaccaa ttggaatcat tatgctatcg ttttagatgt 233701 cccagaaaat agcgctgtga tatcttttgg cgttcaatta tctgggccgg gtcaggtgtg 233761 gatggatcat gttgtttttg aagaggtaga tgagagcgtt ccttcaacaa accttgaaat 233821 gccgggagaa cttttagatg aaccggtaaa tttatctttt gaagaggaac tacaaaaata 233881 gttttcagac aactactttt attagtgagt taatggaaaa tactatttgt tattaataaa 233941 cccttgtgct gcttaggttt gtaagagctt ggatattttt atcagtctgg gcggatctgt 234001 tcatctttgc ggcattttcc tgtatgatat agtaagagtg tgcatagcaa ctaactataa 234061 ttgaacaggg tgtttaaaac atggaaaaac aatacagagt attactttac tataaatatg 234121 ttccgattga agatccagag gcgtttagag agcagcatct ggctttttgt aaggagcttg 234181 gtttgttagg ccgtatcctt gtttcttctg aaggaattaa cggtacggta tcaggtacgg 234241 ttgaacagac tgaaaaatat atggaaacaa tgaaagctga tcctcgcttt gcggacatgg 234301 tatttaaaat tgatgaagca gaaggccatg ccttcaaaaa aatcttcgtc cgccataaaa 234361 aagagcttgt aacgcttcgt cttgaagatg atgtcgatcc gaacgaaaca acaggccagc 234421 atttgaagcc tgcagaattt tatgagaaga tgcaggatcc aaacacaatt gtcatcgacg 234481 cgcgtaacga ttacgagtat gaccttggcc atttcagagg tgcggtccgt cctgacatcg 234541 aagccttccg tgaattacct gaatggattg aagagcacaa agatatgctt gaaggcaaaa 234601 agattttaac gtactgtaca ggcggcgtgc gctgtgaaaa gttctcagga tggctggtga 234661 agcaaggctt tgaagatgta gctcagcttg atggcggaat cgtgacatac ggaaaagatc 234721 cagaggtgca aggcaagctt tgggacggcc agtgctacgt atttgatgaa agaatcagcg 234781 tgcctgtcaa ccgtgtcgag catgtgattg tcggcaagga ctactttaca ggagaaccgt 234841 gtgagcgtta tgtgaactgc gcaaatccat cttgcaataa aaaaatgata tgcacaccgg 234901 aaaatgagta taaatatatg cgcagctgca gccacgaatg ccgcacgaac ccaagaaacc 234961 tgtatgtgaa agagcataat atgacagaag aagaagtaaa cgcaagactg gcagcgattg 235021 aaacagaaga tcacgctgct gctgaataaa aaaagaacac ctcgtattga ggtgttcttt 235081 ttttctatat gctttcagtt tggctgtttg cggaaaccca ttctttttgg cggaaggcct 235141 tttcccattt tgataccacg atacaggcga tcgcatgtcc cggtacgttc acgcctgttc 235201 tcgccatgtc catgacgcgg tcaacacccg cgataatggc aacgccttca gccggcagtc 235261 ctacagcatt ggcagtcgcc agaagaacta caagcgatcc tgagggtaca gctgcaatgc 235321 ctttactggt catcacaagc acaagcatca tgagcagctg ctgggacaat gtcatgtcta 235381 cttgaaaggc ctgtgcgaga aagatacaag aaaccgataa atataagctg gagccgtcac 235441 agttcaatga caagccggag ggaacgacaa atgataccac tcgtttggga cagccgtatt 235501 tctccattct atccatcagc tgagggagaa tggtttcagt gcttgtggtg gaaaatgcaa 235561 ttaaaaacag atcccatatc attttcaata cttcgaaata cttaatctga aagatgagac 235621 cgacaagcgg aaagaggaca aagaggatca ggaacaggcc aaggaatacg gtgccaacca 235681 gcttaaacat agggaggagg agttcaatgc catattggcc tacagaagca gccatcaggg 235741 ctaacacgcc gataggagca gtgaccatga cgatttgcgt gagcttgaac ataatctgag 235801 ctgtagattc aaaaaacttc attactggtt cagaagcttt gccgatacca gctgcggcga 235861 caccaaataa aatggcgaag aaaataacgg caagcaaatc atttctggcc atgacatcaa 235921 taatgtttgt agggataata tccaggatca tttgcttgaa atcaacaact ttgtctgtgt 235981 agccggaaag ttcatgaata tctttttttg ccaaatggga gaggtcaagc ccgacacctg 236041 gttttaagac attcgctaat aaaagtccaa gccctaatac caacgttgta atcacttcga 236101 accaaatgat cgtcttgatg ccgagactgc ccattttttt catgcttccg cttcctgcgg 236161 ctccaatgac aatggtagaa aatacaatcg gcacaacaat cattttaatc aggcggataa 236221 atccatctcc gacaggcctc agtgccatcc cgaaatcagg aaaaaagtgg ccgatcaccg 236281 cgccgacagc caaagcgatt aaaatttgaa acgcgattaa ttttttcaaa tgaatccccc 236341 tttagaacga tagaatgtag gcatattcat atcattcgtg attcaaatgc aaacaccttt 236401 tttcaagtta ttttattttg acagcgcttt cattatgttg gcgaaaaagt cccccgcagc 236461 aggggggact tttttacttc atttgaatgt gctttagatc ttcttcagag gtatttgtga 236521 aaataaccgg tgttatggct gaagcggcat gctgcttgat gtaattgaga tcaaaggtga 236581 gaagcagttc gccttgtttg acggcttgtc cgcttgtgac atgtgcttca aagccttccc 236641 cattcagttt gacggtatcg atgccgacat gaatcaggat ttcagtgccg ccggcgctca 236701 taaagccgat ggcgtgtttt gtcggaaaaa tcgagacgat ctcgccgtcc gcaggtgcaa 236761 cgacttttcc ttctgatggt ataatcgcaa atccctcgcc catcattttt tctgaaaaga 236821 cctgatcagg cacatcccct aaagagactg tttctccttt aatcggataa ataaaggtct 236881 catcggaatc gggcttcagc ggtttgtcag ttaccgtgtc cagcgcggcg gcggtggcag 236941 ggacgcctcc ggccatgatt gttttgatgt cgtcttttaa ggcatcggac ttggttccga 237001 atattgcctg gaagttgttg ttgacctcca gcacacctac tgcaccaagc cgttttaatt 237061 catccttgca gacttggctt ggctgatgaa cggtcacacg aagccttgtg atacatgcat 237121 ccaggttagc gatattttgc tgtccgccca aggcctgcag cacgtgaaag gcaagctggt 237181 cttttgcaac tggagctttc tcctcattct gaccgtcttc atctgtctca cggccgggcg 237241 ttttcaaatt ccatttcaga atcgcaaatc ggaacaaata ataataaatg aaagcaaaca 237301 cgatcccgac aggaatgaca acccagccgt ttgtagacag tccgtagttc aagacgtagt 237361 caattcctcc gcctgagaac gtatagccgt ggcggacatg gaataaatca caaacgacaa 237421 agatgacgcc ggcaagaata gagttaatca aatagagcac gggcgcaacg aacaagaaag 237481 aaaactcaac cggttctgta attccggtca gcatagatgt gagcgccgca gaaatcatca 237541 cgccggagat catttttttc ttttccggac gcgcggtatg gataatggca agagcaacgg 237601 ccggcagaca gaaaatcatg taagggaaat cccccatcat aaagcgcccg gctgtcgggt 237661 ctcccgcgaa aaaccttgtc aggtcgccgg ttacggtgtt gcctgttgat gggtctgtgt 237721 attctcccat cataaaatag aaaggcgtat aaaaaatatg atgcaggcca aaaggaatca 237781 gcaaacgata gatcgttgca taaaagaaca ggccgactgt tgaatcggca attaaactgc 237841 tggctgcgtt aattccgttt tggatcagcg gccaaacgaa tgagaaaatg acgccgatca 237901 ccaatgaact gacggaagta atgatcggga caaagcgttt tccagagaaa aatccaagga 237961 ccggatgcag ctcgattgat gaaaatcgct tatataaata ggcggcgaga agcccgataa 238021 tgattcctcc gaaaaccccc atatcaatca ggtgctcggc tccttcatac ggaggctgaa 238081 ggccgagtaa ttttcccata ttgtcgaggg tgacggttaa aattaagtat ccgatgacag 238141 cggcaagtcc ggctacacct tctccgccgg ctaatccgat cgcgaccccc acggcgaaaa 238201 tcagcggaag gttatcgaat acaacgccgc ccgcatcctt tataataggg atgttcagta 238261 aatccttgtc tccgaaacgg agcaaaagac ctgctgccgg caggacggca accggagtca 238321 tcaacgcgcg gccaagctgc tgcagaattt gaaatgcctt tttaaacatg acagtctcct 238381 tttattgtgt tatgagaatg atgcactctt taatttttga gctgctttat aatcggcgat 238441 aacggttaca tgattgtgtt tttgaagaat ggaggctggt acatctgtcg tgacaggacc 238501 ttcagccatc ttttgaatgg cgtctgcttt ttcctcgccg cttgctaaaa gcacaatatg 238561 tttgctgaat tccatgatgg ttttaatgcc cattgaaatc gcgagtctcg gaaccagcac 238621 cggatcgccg ccgaagaatc tggcatttgc ctgtatcgtg ctttccgaga gcttcacaac 238681 acgtgtccgg tcttcaaaat cagatcccgg ttcattaaaa ccgatatggc cattggcgcc 238741 gatgccgaga atttggacat caatgcctcc cgcctggcgg atgagatcct cgtatacttt 238801 gcatgccgcc tcaagctgcg gattgtctcc ttgcgggata tgaatatgat caggctgcat 238861 attgatatgc tgaaaaagat gctcatgcat aaaatggtta taactttgcg gatgagatgg 238921 agagagacca gcatattcat ccaaattaaa tgtagtaacc tttgaaaaat caatttcgcc 238981 tgcctgatag tctgaaatca actgcttata caagccgacc ggtgtgcttc ctgttgccag 239041 gccgagaacg gcatctttct tagcttgtat ttgttcttta ataatggcag cgcttaactt 239101 acagagttct tcgtagtgct cggcgatcag aatcttcatg tgacaccccc tcaaagagat 239161 agacaagcac catatttgtt atgaccaatt tatgatactt gtcattacga atttagcacc 239221 gcccttatca aactgtcaat attaatttct gaaaatttgt tataaaagaa ggatacaaat 239281 ctttcatatt gggagggcaa atggtattat ggtctcaatg aaaaagaacg gattgcatac 239341 agaatgggga gaatgaaatg acagctttat attctgttat caagtttaaa atcattgagt 239401 taattaaatc gggcaaatat caggcgaatg atcagctgcc gacggagagt gagttttgcg 239461 aacaatatga tgtcagcaga acaactgtga gactggctct gcagcagcta gagcttgagg 239521 gatatattaa aagaattcaa ggaaaaggga catttgtatc ggcggccaaa atacaaacgc 239581 cgattccgca taagattacg agctttgcag aacaaatgag aggacttcgt tctgaatcaa 239641 aagtgcttga gcttgtggtg attcctgccg atcattccat cgccgagctt ttgaaaatga 239701 aagagaatga acctgtcaac aagcttgtca gagtcagata cgccgagggg gaacctttgc 239761 agtatcatac ctcatatatt ccctggaagg cggcaccggg gctggcgcag gaggaatgca 239821 ccggctcgct gtttgaattg ttaaggacaa aatacaatat tgaaatcagc aggggcacgg 239881 aatcgatcga accgatttta acggatgaaa cgatcagcgg acacttatta accaatgtcg 239941 gagcgcctgc gtttttatca gaatccctta cctatgataa aaatgaagaa gtggtggaat 240001 atgcgcaaat tattacacgg ggagaccgaa cgaaattcac cgtagaacag tcatatcatt 240061 cataaagcaa tgtgttttaa gaagggaatg gtggttctat gtttttattt acgaatggaa 240121 aagtgctgtg gggagcagtg attgctgcat tcatcctttc aattgtattt tacccttttc 240181 tgccgacgca gatgccgatt cattatgatg ttgcgaacag tccggatctg acggttaaca 240241 agctggcggg gactgtgatg ctgcctgttt tgatggtggt gtttgcatgg gcgcggaaga 240301 tcaattggca atttgtattc gcagtgtata ttttgctgat ttgccacatt gtcgtccttt 240361 gtttagcgct ctaaatcaaa cagccagaat aaaactggct gttttcttta atttcagctt 240421 catctgacaa tgaatgtggt gtataatagc tgatgatcct aaagaatatt ctgaaattta 240481 taggtgtgaa gcggcgtatt attaaaggaa aggctgtata ctttttgcag ctttaaaaag 240541 actgaatatt taaacaatta tgtgaaaggt gtgctgatta gattgaataa gcttattgaa 240601 cgagaaaaaa ctgtatatta taaggaaaag cccgacccgt cttccttggg gtttggacaa 240661 tattttacag attatatgtt tgtgatggac tacgaagagg ggattggatg gcatcatccg 240721 agaattgcgc cgtacgcacc gcttacgctt gatccgtctt catctgtttt tcattacggc 240781 caggctgttt ttgaaggatt aaaagcatac agaacagacg acggcagggt gctgctgttc 240841 cgtccggatc aaaatatcaa acggctgaac agatcgtgtg agcgcatgag catgccccct 240901 ttagacgaag agctggtgct tgaggcattg acgcaattag ttgagctgga gaaagattgg 240961 gttccaaagg aaaaaggaac gtcactgtat attcgtcctt ttgtcattgc cacagaaccg 241021 agtctcggtg tgaaggcatc caggagctat acatttatga tcgtgctttc gcctgtcggc 241081 tcctattatg gcgacgatca gctgaagccg gttagaatct atgtcgaaga tgagtatgtg 241141 agggcggtca acggaggagt cgggtttgca aaaacggctg gaaactatgc cgccagtctt 241201 caggcacagc ggaaagcgaa tgaactgggc tatgaccagg tactgtggct ggacgccatc 241261 gaaaagaaat atgtggaaga agtagggagc atgaacatct ttttcgtcat aaacggggaa 241321 gctgtcacac ctgctttaag cggaagcatt ttaagcgggg ttacacgtgc gtctgcgatt 241381 gaattgattc gaagctgggg cattccggtt cgtgaagaga gaatatcgat tgatgaggtg 241441 tatgcggcct ctgcacgcgg agaattgaca gaggtctttg gcacaggcac ggcagcagtc 241501 gttacgcctg tcggtgaact caacatccat ggaaaaacgg tgattgtagg cgacgggcaa 241561 atcggggacc tctcgaaaaa gctgtatgaa acgataacag atattcagct tggcaaggta 241621 aaaggcccgt ttaactggac agtggaagtg tgaaaatcga aaaagaacct gcccggaggc 241681 aggttctttt tattttgaat gagtcatatc agcagccggc tggcttttgc ggttttttac 241741 ataatatatt gcatagcaaa tggccataaa tggaacgccg caatagagtg cgattctttg 241801 attcggatca aaggcaatgc caacgacgga agccaggcat aacaggaacg cagcaatcgg 241861 cacgaacgga tacaaagggg ttctgtattt caaatcagta accttgtttc ccgcttcgat 241921 ataacgtttt ctgaacatga attgagaagc agcgattccc atccacacga caacgacggc 241981 aaaaccggaa atcgacacga gcacaacgta tacagtgtct ggcgcaaata cgctggacag 242041 caacgacaga atgccgccga tcatgctgaa caccagcgcg ttaaaagggg ttccttttga 242101 cgtcagcttt gcaaatgtcg gatgaagcgt tttttctttt gataaagacc acagcatccg 242161 ggaagaagcg tagagtccgg aattagccgc tgacaggatc gctgtcagga taacaaagtt 242221 catgatatcg gctgcgtatg gtacaccgac tctgtcaaag acagcgacaa acgggctttt 242281 gatgacacct gcatcttgaa tcggaatcag ccctgacagc acaaaaattg ttccgacaaa 242341 gaagagcgag agacgccaga ccgttgtttt tatcgctttt ggtatcgtct tgtcaggatc 242401 aacgctttca ccggctgcga ttccgattag ttccgttccc gaaaaggcaa aattgacgga 242461 cagcatcgtc atcaaaatcg ggacaaatcc attgggaaaa agcccgcctt ccgccgtgaa 242521 gttggacagc atcggagcgg cttctccgcc tttgatcggg atgatgccga acatggcaga 242581 gccgcctaaa agaataaata atacaatggc taatactttg atgctggaaa accaaaattc 242641 tgattcagcg aaaaacttga ccgaaaatgc gttaagcaag aagatgaaca gcgcaaagac 242701 ggcactccac atccaaaccg atgtatgggg gaaccagcgc tgcattaaca ggccggctgc 242761 tgtgaattct gatcccaatg ccacggtcca tgtcagccaa tacagccaag cgaccgtaaa 242821 tccggtgccc ggccctatgt atttggctgc ataggtgtga aaggcgccgg tcacaggcat 242881 ggcgactgac agctcaccga ggcatagcat gaccagatag acgatgccgg ccccgactaa 242941 gtaggcgagt atcgttccgg ccgggcctgc ttgctgaatg gtataacctg agcttaaaaa 243001 cagcccggtt ccgatgacac ctcccaagga aagcataaag aggtgccggc ttttcatact 243061 tctctgaaag gttgtctcat tcttgttgtg ggcagagttc atctttttcc aactttctat 243121 cagcgattta tttccttcct aataaaaaat ctcatgtcag aaagtgacac gagactccgg 243181 cgaaccggct ttaagttaga atatacaaac tattccgata agtcaagttg tttttaaaga 243241 gcgggcccaa gccgcaattt cttgaatatt ttcgggtttt gtccggcagc agccgccaat 243301 cagcctcgct cctttttcat gccaggtgcg ggcgctcgcc ccgtaagatt ctgcgcatgc 243361 tgcgccgttc cacgtttttg tttccggatc atattgctca cctgaattcg ggtagacaat 243421 gatcggtttt gacgtgttct tttttaactc ctctatcaag gaagggatat gctgaagcgg 243481 cgtgcagttg atgccgagtg ctgcaatttg gcggtgttca tcaagccacg atgcgcagtc 243541 agctgcaggt gttccgtcac tgatatgcaa gccgtcttta gcactgaagc tgatccatgc 243601 atacgtttca ggaaattcct tcaacagccg aacaatcgct ttggcttcag tcagacacgg 243661 aatcgtttcg catgccaata catcagctcc ggcttcaatc agcgccttca tccgggggcg 243721 atgaaattca atcagttcat cttctgatat tgcgtagttg ccgcgatact cagacccgtc 243781 tgcaagataa gcgccataag ggcctataga agccgcaatg atcggttttg gccgattcaa 243841 acggttctct tcaagcgacc aaaattcatc acgtgcttca gctgcgatgc tgacggacaa 243901 ctcgatgagc cggcgtgctt ccgcttcgct cagcccgcgt gcggcaaagc cttcaaatgt 243961 agactgatag ctggcggtga ttgcacaatc ggcgcctgcc gcaaaataat cagtatgaac 244021 ttgtttaatc agctccggct cttccatcag gatttttgcc gaccacagac tgtcattcaa 244081 attacagccc ttgcgttcaa gctcggtcgc catggcgccg tctagcacaa taagcgggta 244141 tgtatctaat atgtgttgga taggattcat agaatgtacc gatgccttct ttcagatttt 244201 tttgaaaaag atatgaaaat cgtaatggag gcttacgtgt ttgtcaataa acgcaaaaag 244261 agaaaggtgt tcagcccata tgtctgaaca cccttttctt atgatatttg tttgttgtgc 244321 gtgtcagtct ttgtgtctga aaccggccag cactcaatgc cattatggtt tttgagcaca 244381 tctttataaa agaccggatc cttgcctgct tttttctggc gtgtatagtc tttcagcgcc 244441 gtaaaaacga cctttgatag taagaaaatc gcgattaaat tcacgatgac catcaaaccc 244501 atgaacaaat cagcaagatc ccagacgagc tggactttgg caacacagcc aaacacgatc 244561 attgccagca cgccgatacg gtagacaaaa atcagttttt tgcttttgtt caaaaagccg 244621 atattggttt cgccataata atagtttcca attagagcac agaatccgaa taacaaaatc 244681 agaatcgcga gaaagcctga tgcccatgat ccgacatggg agctgaggga ggcttgtgtc 244741 aaggcgattc cgctcagacc cggagtatga taggcatccg aaaacagaat gataaaagcg 244801 gtgcttgtac aaatgaccag tgtatctgtc agtacaccaa aagcttggat cagcccctgt 244861 ttgacgggat ggcttgttgt ggcggtggca gcggcatttg gtgcgcttcc cattcccgct 244921 tcgtttgaaa agattccccg tctgacgcct tgcatgagtg ccgcgcccaa agccccgccg 244981 gcggcctggt caaaaccaaa cgcatttttc acgattagcg caagcacacc tggcagctgc 245041 gtaatgttgg agaaaatgac gaaaaacgca actccgatat acaggacagc caatacgacg 245101 acaatggatt cagccagctt tgcaatgcgc ttgactccgc caaaaataat cgtgccgaat 245161 acagcaatta aaatgagtcc caatgtcagg cggtttgtgc caaacgcgtt ttcaaaggca 245221 aggctgactg tattggattg aaccgagttg aagacgatac cgaacgataa ggtgattaac 245281 acagcgaaca gcgcgcccat ccaccttttg ttcagccctt tttccatgta atacgccggc 245341 ccgccgcgga agccgtttac atcttttact ttataaatct gagccagtgt gctttccaca 245401 aagctggatg ctgatccgat aatggcgata atccacatcc agaagattgc accgggcccg 245461 ccgagtgcaa tggcgatagc aatgcccgta atatttcccg ttccgacacg ggccgccatg 245521 ctgatgcaaa aggcttgaaa cggagaaatg ctgttttttg accgggaagc agcaccttct 245581 cttaataccc tgaccatttc tttcagcatg cgaacctgta aaaacttaag cctgaacgta 245641 aaatagattc caaaagaaag gagcaaaaca attaatagct ttgaccacaa aagatcattt 245701 gcaataccga cgatatgttc taggatttgc tgcatagaat cacctctttt ttcatgttta 245761 aaaaatgctg agctcccatt cctgcgccat atgcttcagc agcataccgc cagtgaggct 245821 gttgccgtat tcatcaatgg caggcccgta aatgccgatg ccgcatccgg attgaaaagg 245881 ctgttctctt ctggcgcttg gaggcaccag cgccatgatg ccgccggaga cgccgctttt 245941 ggccggcacg ccgacaaacg ccgcatattt gcctgaagcg ttgtacatgc cgcacgtcag 246001 cattaatgcc ttggccaatt ttgccacatc ttttggaatc acctgctcgt gtcgaatcgg 246061 atgatacccg tcatgagcaa ggatcaggcc gatcaacgca atatcttctg tagtgctctc 246121 catagcgcat tgcttcaagt acacctcaag tgtttcttct acttcagctt ctaaaaagtt 246181 tgtttctttt aaatagtagg ccagcgctct gttgcggtgg gcggtttccc attcagaacg 246241 gaatacttct tcatgaattc ttggccgttt tcctatcaaa gtttccatca ccgagtaaag 246301 aaactcgagc ttttcgtatg cagattctcc gggaaggatc gaagcgatgg tgagggcacc 246361 cgcgttgatc atgggattga agggctttcc cggcttgttg atttcgagcc gaatgattga 246421 attaaaggcg tcacctgtcg gctcgacatc tacgcggtca agcacatagg gaatgccgcg 246481 gctcatgcag gcggcaataa agctaatcac ttttgaaatg ctttgcatgg taaaagagac 246541 gttccagtcg ccggcgtgta tcatcgttcc atcaggctcc aatacacaga tgccgagctg 246601 tgaatcattg acttttccta aagcggggat atagtttgcg ctttgtccat tggcggcaaa 246661 agggcgatag tattcaaccc aatcatgaag ctgtaacgcc gggtttatgt ctttctggtg 246721 ctcttttatc aattctttca tcgaattcct cctcactgat ttttttctta aaggactgag 246781 gtgtatcaaa acgaaggcta agggggcgtt aaacgctttc ataatagcgg aaggtataat 246841 tactgtataa tggagactac agaatcatac aaaatacgac aaaaacattt tgaaaataag 246901 cagtaagatt tataaaaacc tcatgttctg ggtcaaaagc aatttgcagg ttttctcccg 246961 attccccaaa ataaaaagcg aggatgtgat caacataaaa ctggaacggt ttattgaaaa 247021 agacggatat atactggccc tcatgctgat tacggtgccg ctggccggtg aactgaaatt 247081 ttatcccctc aatgaagaat tccgggtcag ctttggggca ccggtttttt tcttcttttt 247141 atcattgttg cggcatgtgc ccgctgtgct gccgggtttt ctgactggag cggctgtttt 247201 catctttcgc gtctttctgg aattatgggg cggaggacac aatgggctga ctccgattct 247261 gtatgatcaa gcgtctggct ttttctttta tatgacttac gcctgtctgt tttccatatt 247321 aaaggccaat cgtttccgtg aacggccgat tatgctcggt ttcattgggt ttatgattga 247381 agttgtgtca gattgtgtcg agctaactgt gcaatttctc atttttcata cggttgtcac 247441 gcctgagaaa atcactgaca ttgcggtgat tgcgatttct cacacattta ttgtgatgag 247501 cttttatagt gtgctgaagc tgtatgaaac acaatcgaga gaaaaacaga caaggcagca 247561 gcacgagcac atgctgatga tcgtttccaa tttatatgaa gaaacggtgc acctaaaaaa 247621 gacattgaaa acgacagaga aagtgacaaa cgattcgtat cagctctatc gggaaatgaa 247681 gggcaaggat gttcagctga gcggcagaat cctgagactg gccggagaga ttcatgaagt 247741 gaaaaaggac aaccagcgga tattcgcagg gctttcaaaa ctgatttcga atgagagttt 247801 gagagattat atgagggctt ctgatttgct gcagctcgtg attcgaatga atgaaaagta 247861 cgctgaagca ctagggaagc agattgattt ttactgctcg atcgagggag agcatgacga 247921 atatcacgta tttatcgtgc tttcgatcat taataatcta acagcaaatg cggtagaggc 247981 tatggatgaa gagggaatgg tcagcctgag gctccgtaag ccaaatgaga gtatggtaga 248041 attccaggtg gaagacaatg gccccgggat ttccgagaaa atcggagaca ttgtgtttga 248101 cccgggcttt acttcaaaat atgacgaatt tggcacgcct tctacgggta tcggactttc 248161 ctacgtaaag gaaatcgtga cagagctaga aggggatatc acgtttgata atcagcagcg 248221 gggagtggtg tttgccatca ggctgcctgt ccggcatttg attcagaaag ggtgaaccaa 248281 aagctatgcg tttttttatt gcagatgatg accgtgcggt gcggtcaatt ttaaggcaga 248341 tcattgagga cgaagatctc ggggaagctg ctggtgaagc agacgacgga agccaagtgg 248401 aagggcatat gctgcaattt aagcagattg atattttatt aatcgatctg ttaatgcccg 248461 gaagagacgg cattgagacg attcgtcaga tccagaatac gtactccggc aaaatcgtaa 248521 tgatctctca agtggaggcg aaggaaatgg tcggggaagc gtactcgctc ggcatcgaat 248581 attttatcca taagccgatt aaccgcattg aaattgtcac ggttctccaa aaggtgaagg 248641 agcggatcga gcttgaacac tcgattggag ccattcagca ttctctaagc cggcttgtca 248701 atcggactga acggaaagcg cgtccccagc agaagagtga cagcggttta aaagaggcag 248761 gaacattcct gttgtccgag ctgggcatga tgggagaagg cggcgcacat gatctcatgg 248821 cggtcctgca gtatttagca gaacacgagc aatccgagcc gcacgaaaaa caaagccctt 248881 cgctaaaaca aatattcacc caagtagcgg tacggaagct ggggacagga gcctcacaga 248941 cggaagtcaa tcgcgaaatg aaagcctcgg agcagcgtat ccgcagagcg attattcatt 249001 cgctgcacca ttttgcttca ctgggcacaa ctgatttttc gaatccaaaa tttgaaacct 249061 atgcatcgaa attctttgat tttccggttg tcagccagaa aatgaaagaa ctccaatcca 249121 aggatgcaaa accccttgca cctgctagaa taaatatgaa aaaattcatc cacgtgtttt 249181 ttttggaagc aaagcttttg catgagacga tgaaacaaag aaggatataa accaaacagc 249241 cggctgacca ggctgttttt ttgctgcgca gaatcccggc cggacagtga tttaccgctt 249301 ttttataaaa tatcagaaaa taaagatatt gacttattgt ttatttgtct tacaattaaa 249361 caaaaggata tatgggaagg agcggatgtg aaagaaaaat taataaaagc gcttacagat 249421 agaggccgta tacacaaata acaggaggtt atgttgatga gccgtatcag aaaagcaccc 249481 gctggaattt taggttttcc ggttgctcct tttaacacac aaggaaaact ggaggaagaa 249541 gctctttttc aaaacattga gtttttgctg aatgagggct tggaagcgat atttatcgct 249601 tgcgggtctg gtgaattcca atctctcagc cagaaggaat atgagcaaat ggtggaagtc 249661 gcagtctcgg cagccggagg aaaggtgccg gtctacacgg gggtgggcgg caacctcagc 249721 acagcgcttg attgggcgca gctgtcggag aaaaaaggcg ccgacggcta cttgattctg 249781 cctccgtatt tggtgcatgg cgaacaggag gggctgtacc agtatgcgaa aacgattatt 249841 gaaagcactg acttgaacgc gattctttat cagcgcgata acgcagttct ctctgttgaa 249901 cagatcaaac gtctgaccga atgtgaacag cttgtcggtg tcaaagacgg ggtaggaaat 249961 atggatttga atatcaatct cgtctatacg atcggcgacc gcttgggatg gctcaacgga 250021 atgccgatgg ctgaagtgac gatgccggct tatctgccga tcgggttcca ctcttactct 250081 tcagcgattt caaattatat cccgcatatt tcgcgaatgt tctatgatgc attgaaaaac 250141 ggaaatgacg agcttgtgaa ggaactctat cggcatgtga ttctgccgat caacgacatt 250201 cgcaaacaac gaaaaggcta cgccgtatcc ttgattaaag ccggtatgga aatcatgggt 250261 ttgaatgtaa ggaatacagc cagaccgcct gtcggcccgg ttgaaaaaga tcattatcag 250321 caattggaag caattttgaa gcaggcggct gaccgttttc cgaaaaaagc cgcgacggtt 250381 tgaccagaaa aaacacgaaa ggggcaatgg gcatgtctgt gatcacggaa caaaacacgt 250441 acctcaactt tattaacgga gagtgggtta agtctcaatc aggcgatatg gtcaaagtcg 250501 aaaaccctgc cgatgtgaat gatattgtcg gatatgtaca gaattcaacg gctgaagatg 250561 tggaacgtgc cgtcaccgcc gccaatgaag ccaaaacggc ttggagaaag ctgacgggtg 250621 ccgagcgcgg ccaatactta tacaaaacag cggatatcat ggagcagcgc ttggaggaaa 250681 tcgccgcctg tgcaacgcgt gaaatgggta aaacattgcc ggaagcgaag ggagaaacag 250741 cccgggggat tgccattctg cgctattacg ccggagaggg catgcgaaaa acgggtgacg 250801 tcattccgtc tactgacaaa gacgcgctca tgtttaccac ccgtgttccg ctcggtgtgg 250861 tcggtgtgat ttctccgtgg aacttcccag tggcgattcc gatttggaaa atggcgccgg 250921 cattggtata cggcaatacc gttgtcatca aaccggcgac agaaacagct gtgacatgcg 250981 cgaagatcat tgcctgcttt gaggaagcgg ggctcccggc aggggtcatc aatttggtga 251041 caggcccggg ttctgttgtc gggcaggggc ttgctgagca tgacggtgta aacgccgtta 251101 cgtttaccgg ttcaaatcaa gtcggaaaaa tcatcgggca agccgcttta gcgaggggag 251161 ccaaatatca gcttgagatg ggcggcaaaa accctgtcat cgtagctgat gacgctgacc 251221 ttgaagctgc ggcagaagct gtcataacgg gggccttccg ttcaaccggc cagaaatgca 251281 ccgcgacaag ccgtgtcatc gtacaaagcg gaatttacga gcgctttaaa gaaaaactgc 251341 tccagcgcac aaaagatatt acaatcggag acagcttaaa agaggatgtc tggatgggac 251401 cgatagccag caagaatcag cttgataact gcctgtcata cattgagaaa ggcaaacagg 251461 agggcgcttc ccttttaata ggaggagaaa agctggagaa cggaaagtat caaaacggct 251521 attatgttca gcctgccatc tttgacaatg tgacatctga gatgacaatt gcccaggagg 251581 aaattttcgg tccggtgatc gccttgatca aggtggactc gatagaggag gcgctgaaca 251641 tcgccaatga tgtgaagttc ggtttaagtg catccatctt cacggaaaac atcggccgaa 251701 tgctttcttt cattgatgaa atcgatgccg ggctggttcg gatcaatgca gaaagcgcag 251761 gtgttgagct gcaggcgcct tttggcggca tgaagcagtc gagctcccac tcccgagaac 251821 agggtgaggc agcgaaggac tttttcacag cgatcaaaac tgtttttgtg aagccgtaat 251881 ggtgctggaa agaggcgtgc gtctctttcc cggtttatca caaccagcat atgattctct 251941 actttgaaaa ggagaagata ctatgaaaaa agactttgcg agtgttactc cggcgggcaa 252001 aaaaacgtcc gtgcgctggt tcatcgtgtt tatgctgttt cttgtgacct ctattaacta 252061 cgcggatcga gcgacgcttt ccatcaccgg agattccgtc cagcacgatt tgggattgga 252121 ctcggtcgcc atgggatatg tcttttctgc ctttggctgg gcctatgtca tcggacagct 252181 tccgggcggc tggctgctgg accgttttgg ttcaaagact atcattgcgt taagcatctt 252241 tttctggtcg ttttttacgt tgctgcaagg ggcgattggc tttttctccg ccggcacagc 252301 gattatcctg ctgtttgcac tgcgttttct ggttggttta tcagaagcgc cttcatttcc 252361 cggaaacggc agagttgttg cctcatggtt tccaagctcc gagcgcggga cagcttcagc 252421 cttttttaat tcagcacaat acttcgcaat cgtcattttt tctcctttaa tgggctggct 252481 tacccactct ttcggctggc attccgtttt cgttgtcatg ggtattgcag gcattcttct 252541 ggctgtcatc tggctaaaaa cggtgtatga accgaaaaaa catccgaagg ttaatgaagc 252601 tgagcttgcg tacatcgaac agggcggcgg gctgatttcc atggatgaca gtaaaagcaa 252661 acaagaaaca gaatcgaaat ggccgtatat caaacagctg ttaacgaacc gcatgctgat 252721 tggcgtgtac atcgcgcaat actgtattac gactctcacc tatttctttc tcacatggtt 252781 tccggtatat ttggttcagg cccgcggcat gtctattctt gaagctgggt ttgtcgcttc 252841 cctgccggcg ctgtgcggat ttgccggcgg cgtgcttggg ggcattgtgt cagacatctt 252901 actcaaaaaa ggccgttcac tgacctttgc aagaaaagtg ccaatcattg ccggcatgct 252961 gctgtcttgc agtatgattg tctgtaacta cacagattca gcatggctcg tcgttgtcat 253021 tatgtcgctc gcgtttttcg gaaaaggctt cggcgcattg ggttgggctg tcgtgtcgga 253081 cacgtctccg aaagaatgtg caggattaag cggcggtttg ttcaacactt tcgggaatat 253141 tgcctcaatt acaacaccga ttattatcgg atacattgtc aatgccactg gatctttcaa 253201 tggcgcgctt gtgtttgtcg gcgctaacgc gattgcggcg atcctcagct atttgctgct 253261 ggtcgggccg atcaaacggg tcgtgttaaa gaaacaagaa caagaccccg atcaatcgtt 253321 gcctgtctaa tatttatgaa agcgctttat aaagggagga aaatgcatga gttcaccgat 253381 acaagagcag gttcaaaaag aaaaaagatc gaatattccc tcaatttctg aaatgaaggt 253441 gattcctgtt gcgggacatg acagcatgct gctgaatcta agcggagcac acagcccgtt 253501 ttttacccgg aatatcgtaa tcttaacaga cagcagcgga aatcagggag tcggcgaggt 253561 gcctggcgga gagcatattc gccgcacact ggagctgtca gagccgcttg ttgtcggaaa 253621 atctatcggt gcgtaccagg cgatattgca aacggtcaga aagcagtttg gcgatcagga 253681 caggggaggg cgaggaaacc agacgtttga tttgcgcacc actgtgcacg ccgtcaccgc 253741 actggaagcg gctttgttgg atttgcttgg aaagtttctt caggaaccgg tcgcggcttt 253801 gctgggcgaa gggaagcagc gtgatgaagt aaaaatgctc ggttacctct tttacatcgg 253861 cgaccgaaat cggacgacct tgccgtatca aagcgatgag cagtcagatt gtgcgtggtt 253921 ccgtctgcgc catgaggaag cgctgacgcc ggaggccatt gtgcgtcttg ccgaatccgc 253981 acaggagcgc tatggctttc aggatttcaa attgaaaggc ggggtgctgc ggggagaaga 254041 ggaaatcgaa gctgttaccg cattatcgaa acgttttcca gaggcaagga tcactcttga 254101 tccgaacggg gcatggtcat tagaggaagc tattgcatta tgcaaaggaa agcaagatgt 254161 gctcgcgtat gcggaagatc catgcgggga tgagaatggc tactccgctc gtgaagtaat 254221 ggctgaattc cgccgcgcga cagggcttcc gactgcgaca aatatgattg cgactgactg 254281 gcgggaaatg ggtcacgcga ttcagctcca cgcggtcgat ataccgctgg ctgatccgca 254341 tttttggacg atgcaagggt cggtgcgggt tgcgcaaatg tgccatgatt ggggtttgac 254401 atggggctcg cactccaaca accactttga tatttccctt gcgatgttta cccatgtggc 254461 agcagcggct ccggggcgga tcacggcgat tgatacccat tggatctggc aggacgggca 254521 gcgattaacg aaacagcctt ttgagatttc ttctggctgt gtcaaggtgc cggataagcc 254581 tggactaggc gtcgatattg atatggaaca agtggaaaaa gcgcatgaga tctatcggaa 254641 aatgaattta ggcgcacgga atgatgcgat cccaatgcag ttcctgatca gcaactggga 254701 atttgaccgg aagcgcccgt gtcttgtgcg ataagtttga ttgtaaatat tgtcatatcc 254761 gctattttgt cttacaattg aacaactgaa gggagagttg ttcgtgtacg aaggtttaga 254821 ggatttgaaa gtcgatacag tcaatcggaa aacattagcc aagcaggtca tcgaacggat 254881 tgtccattta ttatcgagcg gacagttgag ggccggagac aaattgccga cagaaatgga 254941 actgatggac attttgcatg tcagcaggcc ggtgctacgg gaagcactca gttcacttga 255001 aacgctgggc gtcattacga gaaaaacacg agggggcaca tatttcaacg ataaaatcgg 255061 catgcagcca ttttccgtca tgcttgcttt ggccactgat aatcttccgg ctatcattga 255121 agcgcggatg gcgctagaac tcgggctcgt gacaattgcc gcggaaaaaa tcaatgagga 255181 agagcttcag cgtttgcaga agacgatcga cgatattgcc aacagcactg acaatcatta 255241 tggtgaagcg gataaagagt tccatcgaat tattgcgtta agcgccaata accccgtcgt 255301 tgaagggatg attcagtccc tgctgatcac ccatgcgaaa attgacagcc aaattccgta 255361 cagggagaga gatgtaacgg tcgaatatca caaaaaaatc tacgacgccc ttgccaaaag 255421 agatccgtac aaagcacatt accacatgta tgagcatctg aaatttgtcc gtgacaaaat 255481 tctaaaagga atggatgaaa aataatggtg agcaaccgca gttgaaacgt aagagctgcg 255541 gtttttttaa accaatttag aaaacgctta ctaaaatatg aggagtgatt ttcatatggc 255601 gatgaacctc aggaagaacc aagcccccct ttacatcaaa gtgcatgaaa tagataacac 255661 cgcgattatt gtaaatgatg gagggctgcc aaagggcact gttttctcat gcgggctcgt 255721 acttgaagag gatgttcctc aaggccataa ggtggccctc accgatctca atcaagggga 255781 cgagatcgtg cgttacggag aggtgatcgg atttgctgat gagacgatca aacgcgggag 255841 ctggatacgg gaagccctcg tgagaatgcc cgctcctccg gcgttagacg atcttcctct 255901 cgcaaacagg gtgccgcagc cgcggccccc acttgaagga tatacatttg aaggataccg 255961 aaatgcggat ggcagtgcgg ggacaaaaaa tatcctcggc atcacgacaa gtgttcaatg 256021 tgttgttggc gttttggatt atgcagtcaa acgaataaaa gaagagctgc tgccgaaata 256081 cccaaatgtc gatgacgttg tgccgctgca tcatcaatac ggatgcggcg tggcgatcaa 256141 tgcgcccgac gctgtcattc cgatccgcac gattcaaaat cttgcgaagc atccgaactt 256201 cggcggtgaa gtaatggtaa tcggattggg atgtgaaaag ctcctcccgg aaagaattgc 256261 ctccgaaaat gatgatgaca ttctatcgct ccaggatcac cgaggttttg cggcgatgat 256321 ccaatccatt ttggaaatgg cggaggaacg gttaatcagg ctgaacagca gaacccgggt 256381 gtcatgccct gtttcggatc tggttatcgg cctgcaatgc ggcggcagtg atgcgttttc 256441 cggcgtgacg gcgaaccctg ccgtggggta tgcggctgat ttattggttc gcgcaggtgc 256501 aacggttttg ttttctgaag tgacagaggt gcgggatgcc attcatttat taacgccgcg 256561 ggctgtcagt gaagaggtcg gacaatcgct gatcaaagag atgaagtggt atgacagcta 256621 tcttcggcgg ggagacgcag accgtagcgc aaacccgtca ccaggcaata aaaaaggcgg 256681 attatccaat gtggtggaaa aagcgttagg ttcggtagcg aaatcaggca caagccccat 256741 ctccggcgtg ctcggccctg gtgaaagagc aaagcaaaaa ggcctgctgt tcgcggcgac 256801 accggcaagc gattttgtgt gcggcaccct gcagctggct gcgggcatga atttgcaggt 256861 gtttacgaca gggagaggaa caccatatgg cctggctgct gcgccggttc tgaaagtatc 256921 gacgcggcat tccttatcag agcattgggc tgatttaatc gatatcaatg ccggccgaat 256981 cgcgacagga gaggccagta tcgaagacgt aggctgggaa atcttcagga cgattttgga 257041 tgtggcaagc ggccgcaaac aaacgtgggc agaccgttgg ggtcttcata atgatttgtg 257101 cttgtttaat cctgctccag tgacttgatt catgttttta tagcggaaag atggaatatg 257161 ctgtaaaatg aaaatcagcg tataggaaac ggaggggtta cagcatggca ttcattagat 257221 tccgagtgac acgaattcaa tagtgaacaa ctctcgcctg aatgcgagag aatcgggatg 257281 aatccgccta tgtatgagcc cttatatggt tatcaaaaaa gagggtggcg tgcctgccct 257341 tttttgtgcc ttcaagcatc ccttctctct actgcaggcc ggagcatgag aaaggggaaa 257401 tgggatgaca aaccttaacg aaaaacagct tatcactgag attgtcgggc ttgcacgcag 257461 ccaaggtttg acggttcatt ctgagaacgc gcaattgaat gaaaccggaa tggactttca 257521 agttgtattt gccaaggacg acacaggtat gccatgggtg ctgcgaaaac cgcggcgaag 257581 tgatgttgtg gaaagagcat ctgcagaagg cataacgctt gcctttctcc gcgcgaatct 257641 gactgctgat gtgccggatt ggagaattca tacaccggaa ttgatcgctt accccatgtt 257701 aaaaggaacg ccggctgctg gaattgactt ggaacaaaag caatatgtat ggaatatgga 257761 tcatcagccg ccgtcagacg actttgtccg cacacttgcc gacatactgg ctgaattaca 257821 tggcacggat caaatatctg ctgggcaatc cggaatagaa gtgataaggc cagaagattt 257881 caggcaaatg acagcagact ctatggttga tgtgaagaat aagcttggcg tatctacgac 257941 gctttgggaa agatggcaaa agtgggtaga tgatgatgca tactggccgg gtttctcttc 258001 tttgatacac ggcgatctcc acccgccgca tatccttatc gatcaaaatg gacgtgtcac 258061 aggacttctg gattggacag aagcgaaggt tgctgaccca gccaaggatt ttgttcttta 258121 tcaaaccatt ttcggagaaa aagaaactgc ccgtttgctt gaatactatg atcaagcagg 258181 cggccgaata tgggcaaaaa tgcaggaaca catctcagag atgcaggcgg cgtatccggt 258241 ggaaatcgcc aagctagctc tgcaaacaca gcaggaggaa cacatcaata tggcgctgga 258301 agcacttggt gtaacatcgg attaagaatt gacttcgttt catgaaccga gtattataaa 258361 ctctacaaat aatagaacgg attaacaatc gtgaggaaga gcaagtacgc atcagaatgg 258421 aggttcagag agtcggtggc aggtgtgaac cgatcctccc ctgatgccga atgggcttct 258481 gaattgcttt gctgaacgga tagtaggcga tgccgggttt ctctccccgt taccaagaga 258541 ggagtatcga aacataggtt ttctgtactt agagtgaacg gctgtatagc tgttaataaa 258601 ggtggtaccg cgagaccctc gtcctttgca taggacgggg gttttttgtg tttcttaaag 258661 gaggtgacgg ccaatgtacg atggctggtg gtggcatagc agatgagtta gaaaggagga 258721 tatcaaatgg tcattgcaac tgatgatctt gaggtcgcat gtcctaaatg tgaaagagcg 258781 ggagaaatcg aaggaacacc ttgcccggcc tgcagcggaa aaggtgttat tctgactgct 258841 caaggatata cgcttctcga ttttatccaa aagcatttga ataagtaaag gagaaaagct 258901 gagctgagat gagagcagaa gagcagagta agattcgtga ggccgcagca ggtacgattt 258961 ttttgctgat cggaacagtt tgttttgcgt ctaaatcgat ttggataaaa tgggcatacc 259021 aaatgggtgc tgagccagat gccgtgctgc tatacaggca gctgctggct gttccgctgt 259081 tttggctgat ttttttaata taccgtcctc caatgccaga cggtaagaaa aaaggagacc 259141 tatggaaggc ttgtggcgcg ggagtgtttt gtttttttct gtctcccttg cttgatttta 259201 tcgggctgaa ccatgtatcc gcaatggttg aacgtatatt gctgatgagc tatccgttgt 259261 ttgtgtttgg attcaccgcg tgtcgtgacc ggaaaatgtc ctcaattcag gaccttttcg 259321 cagttctggc ggtcatgttt gggcttttct tggcgctggg cggctggaat gctgagcttt 259381 tccaggcgaa tatgattgga gctgtattca ttttgttatc ttcggccgtc tatgctggtt 259441 atcttgtcct ttccgggcat ctcgtccatc aaatcggagg gatccgtctc aatgcatacg 259501 ggatgacagc tgctggagct gccatgatgc tttacacagg gataaaatcg gcggctggca 259561 tgaatacgcc aatggcagca tatccgcttt ctatgtatgg tttgttcgca gtaattgcag 259621 tcgttaccac agtgattcca tttgtgctaa tgcttgaggg cataaaacga atcggggcac 259681 agcgagccgc cgccatttca atggcagggc ctatcctgac gattttctat ggagctttat 259741 ttctcggtga acggctcggg ctcattcaag tcattggatg cggtggcgta ttttttgtca 259801 ttacgggcat ggaatacagg aagctgaaaa caggaaaaaa agaataattt ttataaaaca 259861 cacacgtttt tcaattacaa taagtgtaat tacgtgtgtg ttttttgatt ttgtaaaggt 259921 taggtgagga gatgcagcgc atattgcttg tagaagacga ccactcaatc agtgaaatgg 259981 tggatcatta tttaacaaaa gaaggctttg gaattgtgca tgctttcgac ggagaagagg 260041 gcatccggct gtttcagcag ggttcatacg atttggtcct ccttgatatc atgctcccga 260101 agctgaacgg catggatttt ctgaaaatca tccgggaaaa aagcaatata ccggtcttaa 260161 tgatttcggc aaaagatgga gatgtggaca aggcattggg actgggcttt ggggcggatg 260221 attatatcgc caaaccgttt tcgatgattg agctgacagc ccgagtaaaa gccgcgatac 260281 ggcgggcgac gcaatattcg gcagaggagc cggctgtgaa taaggtgatc cggattcacc 260341 agcttgcgat agatatagac aatgtttccg ttttgaaaaa cggagagccg ctccagctga 260401 cgtcaacaga atggcagctg ctgtgcttat ttgcatcaaa tcctaaaaaa gtgtttacga 260461 aagaacaaat ctaccgttcc gtttggaatg aagagtactt tgatgatcag aacatcatta 260521 acgtacatat gcggcggctc agagaaaaga ttgaggatga cccctcctcc cctcaatata 260581 ttaaaacgtt atggggcatc ggttataaat taggagagtt ttagaatgac agtgctatgg 260641 gtggccgctg tcatcgctct ggcgtgtctg aatgtgattc aattcataat gaaaaagaag 260701 cgggacggga atctggctta cacggctgac cagcttagct acatgctcag ccgggattcg 260761 gcaggacaaa ttttgcttcc tacagacgat catgcgctca aagacttgct tgttaacatc 260821 aatcttatcg ttgagaatcg tcagcagatc agcgcccaat ttgccaaaac agagcaatcc 260881 atgaagcgga tgctgaccaa tatgtcgcac gacctgaaaa cgccgttaac ggtcattctc 260941 ggttatattg aagccattca aagtgacccg aacatgccgg acgaagagcg ggaaagattg 261001 ctggggaagc tccgccagaa aacaaatgaa cttattcaga tgatcaattc cttttttgat 261061 ttagcgaaat tagaatctga agataaagag atcccgatca ccaaagtaca tatgaacgac 261121 atatgcaaac gaaatatcct gcactattat gacgctgttc agtcaaaagg ctttcaagca 261181 gccatcgata tccccgatac gccggtgtat gcgcaggcga atgaagaggc tctggacaga 261241 atcctgcaaa acctattgtc caatgcgatt caatatggcg cggccggcaa gttaatcggg 261301 ctgacgctgt cttatgatga gaggaacatc gccatcaccg tatgggatcg cggaaaaggg 261361 attagtgaaa ccgatcagca gcgggtgttt gagaggctgt acacactgga agaatccaga 261421 aataaagcat ttcaaggaag cggcttgggt ttaaccatca caaaacggct tacagaaaaa 261481 atgggaggca tcatatccgt ccaaagcaag ccgtacgaac ggactgcatt tacgatcaca 261541 ttgaaacgca tgacatatta atcgtaagaa tttcttaagg tttgagaaat aaaaatgaca 261601 gggctcgccg ctacaataga aaacaggaaa agagagggaa ggagaaacaa agttgactta 261661 tatcgtacaa acaaacgggc tgaccaaaac atatcagggc aaagaggtcg tatccaatgt 261721 cagcatgcat attaaaaaag gtgaaatcta tggctttctc ggcccgaacg gcgcggggaa 261781 aacaaccatt atgaaaatgc tgacgagcct tgtcaaaccg acaagcggtg aaatcatcat 261841 ccttgggaac aagttcaccc acacgtcata tgaggtgctg gggaacatcg gcagcatgat 261901 tgaatatccg attttttatg aaaacctgac agctgaagaa aatttagatc tgcattgtga 261961 atatatggga taccacaata aaaaagccat acaagaagtg ctggatatgg tgaatttaaa 262021 acaaatcgac aaaaaacccg tcaaaacctt ttccctcggg atgaagcagc gccttggaat 262081 tgcgcgtgcc atcctcacga agccggacct gcttattctg gatgagccgg tgaatggtct 262141 tgaccctctc ggcattaaaa agatcaggca attgtttcaa gtgctgagca aagagtacgg 262201 gatgacgctg ctgatctcaa gccacctgct gggtgaaatc gaacaaatcg cggacacaat 262261 cggcgtcatt cgggacggca ggctgcttga agaggtatca atggaggatg tcaggggcca 262321 gaacactgaa tacatcgagc ttgtcacgcc gaatcagaca agggcctgct ttgtgctgga 262381 gaaagagctg caattaacca actttaaaat attaaatgag aaaacgattc gaatttacga 262441 ggctgaagcc tctcaggctg ccatatccaa agcattgatt ttaaatgatg tagacattga 262501 atcaatgaac aaaaagtata cgtcgctgga ggattatttt atcaaattga tcaacggcaa 262561 tagcatcagt gcgtaaagga ggagagacac gttgatgaat ttgatcagaa tcgaattaag 262621 aaaaatgaaa atgggctggt atatcagagg tgccctcatt gccaacgtga tcattatggg 262681 ttttatgtgg ctgatcagtt attccgaaaa agccgatggc ggggtttcgt tccaaagtac 262741 ggatgaagca ttcctcatca tcggcacctt cgtcagagcg gtatttatcg tatttggcgc 262801 tgtgctgatc gtaaaattgg tgatttcgga atataaaaac aaaaccattc ttgtgatgtt 262861 cacgtacccg atcagccgta aaaagctgct caccgctaag ctcatgatcg cgggcggact 262921 gacgtttatc acgattttac tttcaaatat actcatagcc gccggtttct tttggctgaa 262981 ctcgatctgc catttcatac cgggagagct tacttccgag atcatttctc aacaggcggt 263041 caaaatggcg gttttcgctt ttggcgccgc tggaaccagt ttagttccca tcttttttgg 263101 gatgcgtaga cactcggttc cggcgaccat catttcatct gtagtaattg tgatgctcat 263161 cagctcaaca agtccgggct tctcgatttc atctgttgtg tatatcccgt tatcgttagc 263221 ggcattcggt ttgttctttt cctacatggc gatcaggaat gcggacaagc aggatgcgta 263281 aacaaaggcg cccaatatgt ataaaaggcc gatgctgtca gcaccggcct ttccattatg 263341 agtctgttct tgtttcaaga taatgcttct tgccaatctc tttgctcatc atatagaaat 263401 ggaagcaata ttcaccgatt gccatgacga tcgcgccgaa taaagccgcc aatgcaactt 263461 caccgccagt catccccata gaaagcggca tgcccatcag ccagatcacg agaaaggcca 263521 aaccaaaatc agccaaagtt gcaatcatat tattccattt cggcaataca taaagatcgc 263581 ccagcaaata agaaataacc cctaacacaa tcgtcattag cagcgtatca ccaaacgtga 263641 aaccaaagcc cagaccaagc accagataca acacaataat cgtcataata cctttaatag 263701 cgagcgcttt cacatgtgtc attacaattc ctccttttgt catttgattt gttatgtata 263761 attcctcaaa tgtaaaaagt taaaccttat ttcttttcgg aggcgggtgc aaatctgctg 263821 gggagaggtc aatgatgtga atccaggaat tgaggctgcg gcgcttcgac agcggaaacg 263881 tgaagcttgt actgcaccgg acgctgcttt gatgcccaac agcccattat gtttgctgtt 263941 tttagatgaa taaatttaaa aacttctcct gtccctccgt catcacttct gaagtaatga 264001 aatatgatga aaagagatca aggggaggtg acgtgatggc ggtcgtgaga gcaacgagtg 264061 cggatgtcga tttgatggca aggctgctca gagcggaagc ggaaggcgaa ggcaagcagg 264121 ggatgctgct tgtcggcaac gttggaatta atcggctgcg ggcgaattgc tcagatttta 264181 aaggcctccg caccatcagg cagatgattt atcagccaca cgcgtttgag gctgtgactc 264241 atggatattt ttatcaaagg gcgcgagata gcgagcgtgc ccttgcacgc cggtcgatta 264301 atggtgaaag gcgctggcct gcaaaattta gtttatggta cttcaggccg cagggggact 264361 gtccagccca gtggtataac cagccgtttg tggccagatt taagtcacac tgcttttatc 264421 agccgacggc ggagacgtgt gaaaatgtat ataacacatt ttagagacag gacaccgttc 264481 aaattgaacg gtgtttttct ttgaaaagat gcaatgcaaa atattcctgt gagataatca 264541 aagaaaaaag agctgacgga gatgacagaa tggcaacaat tgacctgcaa aagaaaagtg 264601 taaagatcgt actggagaaa aagcagttaa cgaaggtgac ggctcgtgtt ggactggttc 264661 ttgatattac gggatcgatg agaccgctct acaaaaacgg gacggttcaa aatgtggtgg 264721 agcggatttt ggcagtggct gatcagtttg atgataacgg tttgctggat gtatgggtgt 264781 atgataatga attttcccga ttaaagccag tttcagaaaa ggatttttcg ggctatgtcg 264841 atcgtgaaat tttaaataat gaccgcttgc ataaattcgg cagaaatgat gagccgccag 264901 tcatgaagga cgtgctgcgc aaatatgtta cggaggaacc gagctcgtat cctgctttca 264961 ttgtttttat caatgacggg ggctgtaaaa agtcaatcaa accgataatt gaagcttctt 265021 ctgataaacc ggtgttctgg cagtttgtcg gcatcggaaa cggaaacttt gattttctca 265081 ataaactgga tacgttagaa gggcgtgtca ttgataacac gaacttcctg catatcgaag 265141 agattgaccg catttctgat gatgagcttt atgatgctct gcttgctgaa tttccatttt 265201 ggctgaaaga agcgaaggaa aaagggattg taagagaaca agagcctcct gctgaaaagc 265261 cgaaaaagaa gggctttttc agcagattgt tttcgaaata actgataaag agcactgagt 265321 cattctgcga aatggctcgg tgtttttgtt tttttaagat catgtgaaga aaaataggcc 265381 gaatgggcgg cttgcaaacg acaggatatg cagaaaacgc gtcattcagc cagctttcgg 265441 catgtttcag cagcaggctt gtgagggaag acctgttttt aatgttcagc gcttacaatc 265501 agttcacact tcttcacagt cgtttaacaa tgatttccta taatggagac gatcaatgag 265561 gagagagggg atcttgaatg gcatacgaca gtcgttttga tgaatgggta cagaaactga 265621 aagaggaaag ctttcaaaac aatacgtttg accgccgcaa atttattcaa ggagcgggga 265681 agattgcagg actttctctt ggattaacga ttgcccagtc ggttggggcc tttgaagtaa 265741 atgctgcgcc taacttctca agctatccgt ttacattagg ggtagcgtca ggtgatccgc 265801 tttctgacag tgtcgtgctt tggacacgtc tggcaccaga tccgctgaat ggcgggggaa 265861 tgccgaagca agcagtgcct gtcaaatggg aggtcgcaaa ggatgagcat ttccgcaaaa 265921 tcgtaagaaa aggcactgaa atggctaaac caagtcttgc ccattccgtt catgtggaag 265981 cggacgggct tgagccaaac aaagtgtact attaccgttt caaaaccggc catgaactaa 266041 gccctgtcgg aaaaacaaaa acactgcctg cccctggcgc caatgtgccg caaatgacct 266101 ttgcatttgc ttcctgccag caatatgagc acggatatta tacggcctac aagcatatgg 266161 caaaggaaaa gcttgatctt gtcttccatc tcggtgatta catatatgaa tacggcccaa 266221 atgaatatgt atcaaaaaca ggcaatgtcc gcacgcacaa cagcgcggaa atcattacgc 266281 tgcaagacta tcggaaccgt cacgctcaat accgttctga cgccaatctt aaagctgcac 266341 atgcggcatt cccttgggtt gtaacttggg atgaccatga agttgaaaac aactatgcca 266401 ataaaatacc tgaaaaagga cagtcggttg aagcattcgt gctccgccgc gcggcagcat 266461 accaggcata ctatgaacat atgccgctcc gcatttcctc tttgccgaat ggcccagata 266521 tgcagctgta ccggcacttt acgtacggaa acctggcgtc cttcaatgtg cttgataccc 266581 gccagtacag ggacgaccaa gccaataacg acggcaataa gccgccttct gatgaatcgc 266641 gcaatccgaa tcggactctg cttggaaaag aacaggagca gtggctcttc aacaatttgg 266701 gcagctcgac agcccactgg aatgtgctgg cgcagcagat tttctttgcc aagtggaatt 266761 tcgggacaag cgcaagcccg atctacagca tggattcgtg ggacggctac ccggctcagc 266821 gcgaacgggt tatcaatttc attaaaagca aaaatctgaa taatgttgtc gtactgacag 266881 gtgatgtaca cgcaagctgg gcatcgaatt tgcatgtcga tttcgagaag acaagttcaa 266941 aaatattcgg agccgaattt gttggaacct cgatcacttc cggagggaac ggagcggata 267001 agcgagcgga tacggaccaa attttaaaag aaaatccgca catccagttc tttaacgact 267061 atcgcggata tgtccgctgt acagtgacgc ctcaccagtg gaaagccgat tatcgggtga 267121 tgccatttgt gaccgagccg ggcgcagcca tttccacgcg ggcttcattc gtttaccaga 267181 aagaccaaac cgggttgaga aaggtatcat ccacaacaat ccaaggcggg gtgaagcaat 267241 ccgatgaggt cgaagaggat cgtttctttt cgcacaacaa agcccacgaa aaacaaatga 267301 ttaagaagcg tgcaaaaatc acgaattaag gagtggaaat tatgttttca aacattggaa 267361 taccgggctt gattctcatc ttcgtcatcg ccctcattat ttttggccct tccaagctgc 267421 cggaaatcgg gcgtgccgcc ggacggacac tgctggaatt taaaagcgcc acaaaatcac 267481 ttgtgtctgg tgatgaaaaa gaagagaaat cagctgagct gacagcggta aagcaggaca 267541 aaaacgcggg ctgaatgctg atgaggcaga caccgggtct gcctcttttt ttatgaaagg 267601 gagggctttt ttgaatggat aaaaaagaaa cccatctgat cgggcattta gaagagcttc 267661 gccgccggat tatcgtcacc cttgcggcat tttttctatt tctcatcacg gcttttttgt 267721 tcgtacagga catttatgac tggctgatca gggatttgga tggaaagctg gctgtgctag 267781 gaccgagtga aatcctctgg gtgtatatga tgctttccgg catttgtgcc attgcggctt 267841 ctatccctgt tgccgcgtac cagctgtggc gtttcgttgc accggcgctg actaaaacgg 267901 agcgcaaggt gacgctcatg tacataccag gtttatttgc gttgtttttg gcgggcatct 267961 ccttcggata ctttgtcttg tttccgatcg tgctcagctt tttgactcat ttatcctccg 268021 gccactttga aacgatgttt acggctgacc gctactttag gtttatggtg aatttgagcc 268081 tgccgttcgg cttcttgttt gagatgccct tggtggtgat gtttttaaca aggctgggca 268141 tcttaaatcc ttacagactg gccaaagcga gaaagctttc ctattttctg ctgattgtcg 268201 tgtccatatt gattacaccg cctgatttta tttctgattt tctcgtgatg atcccgcttc 268261 ttgtcctgtt tgaagtgagt gtcaccctat cggcgtttgt ctacaaaaag aggatgaggg 268321 aagaaacagc ggcggccgct tagtgcagcg taccacccgg tgacttcaca tcctcatcat 268381 attgtgcggc cgtaacagcg gcgattctca atgcccggac aatcgtgtcc aggctgaggc 268441 tcggcgctgt tttgtcgatt gtttgctgcg gaatgtaagg aatatgaata aaaccgccgc 268501 gaatgtgtgg ggatgtccgg ctaatgtgat ccattaaccc gtagaacaaa tagttgcata 268561 caaaggtccc cgctgtgtag gaaaccgcag ctggaatgcc gtgttccttc atcttagcag 268621 tcattcgttt cacgggaagc cttgtccagt aagcggcggg cccatctgga gaaatctctt 268681 catcaatcgg ctgatgtcct tcgttatcgg ggattcgcgc atctgcaagg ttgattgcca 268741 ctcgttccgg tgtaatctgc atccgtcctc ctgcttggcc gacacaaatt acgatatctg 268801 gctgatgttt ttgaatggct tggcgcagag tgtccagagc ggatctaaag acggttggaa 268861 tttgttccgc tgtaataatg gcttcttctg tctcgaagcc attaagccgt ttcgccgctt 268921 cccatgatgg attgacggtt tctttgtcaa aagggtcaaa gcctgtgatc agcacttttt 268981 ttctcattct cccatctcct ttttctttta ttctattgtt tatttatggg tttttcatca 269041 aaataatgta aaggagtgaa tcataatgga gcatttgccg gagcagtatc gccagttatt 269101 cccaaccttg cagacgcata cgatgcttgc cagctgttct cagagcgcat tggcagagcc 269161 tgtatcaagg gcgatccagg attattatga tagcctgctg tataaaggga cgaactggaa 269221 agaagcgatt gaaaaaacag agtttgcgag aaacgagttt gcaaagctga tcggggctga 269281 accggatgaa gtggcgattg tgccgtcagt ttctgatgca ctggtttctg tagcatcgtc 269341 cttaactgca tttggaaaga agcacgttgt atatacagat atggattttc cggcggtgcc 269401 tcatgtttgg caggcacact ccgattatac cgtatccgtc attccatcaa tagacggcgt 269461 gctgccgctt gaacaatatg aaacgcatat ttcggatgaa acagtactga cgtgtgttcc 269521 tcacgttcat tatcgtgacg gctatgttca ggatataaaa gcgattgccg agatttctca 269581 gagaaagggc tctttattgt ttgtagatgc ttatcaatca gccgggcata ttcccattga 269641 tgtgaaggaa tggggcgtag atatgctggc agcaggcacc cggaagtatt tgctcggcat 269701 accgggtgtg gcgtttcttt atgtgagaaa ggagctggct gacgcactga agccgaaagc 269761 atcagcttgg ttcggaagag agagcggatt tgatggggct tatgcaaaag tcgcgcgccg 269821 ttttcaaacg ggcaccccag cttttatcag cgtatacgca gctgcagcgg ctttatcgct 269881 gctgaatcat attggggttt ctcatatcag ggatcatgtg aaaacgatct gtgccgatgc 269941 agttcaatat gccgctgaaa aaggcctgca gctggcggcg gcacaaggtg ggattcagcc 270001 gggcatggtt gcgatccggg atgagcgggc atcggaaacg gcggggttgc tgaagaagaa 270061 aaaagtgatt tgcgcgccgc gggaaaatgt tatccgtctc gctccccatt tttataatac 270121 gaaggaggaa atgcggcacg cgattgatga aatcgcggcg aaaacgatcc acaagtaaac 270181 atgaaaaagc ccctgaacac tagtcagggg cttttcatat taatgatcta ctttaacgcg 270241 tttcataaag aaagcgccaa ttaaaccgat aatggcaaca atcattgcaa acacaaatgc 270301 gtgctgtacg cctgctgtca aagcttgcgg gatgactgcc ggatcggcag ggtttttaac 270361 tgtactcata taatcatgct ggcctgcagc cataatgctg accgcaaccg ctgttccgat 270421 agcgccggcc atttgctgca gcgtgttcat aatggcggtg ccgtctggat aaaattcacg 270481 cggcagttgg tttaaaccgt ttgtctgtgc aggcatcatg atcatagaaa tcccgatcat 270541 caagcaggtg tgcaggatga taatcagcac agctgttgaa gtggtcgtga catttgagaa 270601 gaaccatagt acaacggtga caatcacaaa tcccggaatg acaagccatt tcggcccgta 270661 tttatcgaac aagcggcctg taacagggga cataaatcca tttaaaatac cgcccggcaa 270721 gagaacaaga ccagatgcaa atgcagtgag gactaagccg ccttgcagat acatcggcag 270781 aagcagcata gatgacagaa tgaccatcat acaaatgaac accatgatca cacccaaaat 270841 aaacatcggg tatttgaacg cacggaggtt catcataggc tgcttcattg tcagctggcg 270901 gattgaaaat aagataaggc cgacaacgcc gacaatcagc gacacgataa cagtcgggct 270961 ggaccatccc ccggagcctt cacccgcgtt gctgaatccg aatacaatgc cgccgaagcc 271021 aatcgtcgac aggatgatag acaatacatc gattttcggc tttgtcgttt cagatacatt 271081 ttgcatatat gcgataccga aaacaagcgc cagcacaagg aatggaagag agatccagaa 271141 aatccagtgc cagttgagat gctccagaac caatcctgag aaagttgggc cgatggcggg 271201 cgcgaacata atgacaagcc cgatcgttcc cattgcggca ccccgtttat gaggcgggaa 271261 aatcaccaag attgtgttaa acatcagcgg cagtaaaaga ccggttccaa gtgcctgaac 271321 gatccttgcc gctaataaaa acgagaagct cggcgcaagc gccgcaatga atgtacctaa 271381 aattgaaaag ataagtgaca cggtaaaaag ctgtcttgtt gtgaaccact gcaacagcag 271441 tcctgaaaca ggaacaagga taccgagtac aagcaggtag cccgtcgtta accattggac 271501 ggttgccgct gtaatgttca attccttcat aaggtcggtt aacgcaatat tcagcgctgt 271561 ttcactgaac atgccgataa aaccggccaa cagcaaggaa atcataatcg gcatcacttt 271621 gtattgctga gatgctttag ctgttgtttc caaaatcatt tcccctctct atcaactgca 271681 tgtagtatgt cgtttttttt atctcttcag caggtcagga atgcagctgg agatatgaag 271741 gagcggcgta ctgttttttg ccgtcaaaga taaaaggatg ccgccttcaa tcatcgcgtt 271801 aaccacagtg ctggcttctt ttgcacggct ctcgctgcag ccagtctgcc gcagtttttc 271861 ctcatacaca gaggcccatt ctttgtaggc ttcatgacag gcttcgcgca acggttcgct 271921 tttcaatgac gtctcagccg ctagcaagcc cacaggcaag ccttcaatgt cttccgtaca 271981 tgaaaactgg caggagagct ccttcaaaaa ggcttgaatg ccttccgctg gatcggtgca 272041 ggcttccatg cagtccgcga ttttctgacg gatatactcc ttcatctcat tcacggcttc 272101 gatcgcaagc tgttctttac ccccgggaaa gtggtagtaa agagagcctt taggcgcgcc 272161 gctttccttt ataatctggt tcagccccgt gccgtaatac ccttgcagct gaaaaagccg 272221 ggtagctgcc gaaaggattt tctcacggga atctccataa ctcataacat tcccacctta 272281 ctgaattgca atcaaaaata tagtgactgg tctattatct tgattcaatc atcaattgtc 272341 aagaaaaatt cattgtatga aaagacaaaa aaagaaggat atgacaacaa aaaatactga 272401 gagaaaagct gactgatctt ttgactgaat agataaaatg tacaatgatt aatcatcata 272461 tggatgtaag gagagaaata gatgaaaaaa caacgaatgc tcgtactttt taccgcacta 272521 ttgtttgttt ttaccggatg ttcacattct cctgaaacaa aagaatcccc gaaagaaaaa 272581 gctcagacac aaaaagtctc ttcggcttct gcctctgaaa aaaaggatct gccaaacatt 272641 agaattttag cgacaggagg cacgatagct ggtgccgatc aatcgaaaac ctcaacaact 272701 gaatataaag caggtgttgt cggcgttgaa tcactgatcg aggcagttcc agaaatgaag 272761 gacattgcaa acgtcagcgg cgagcagatt gttaacgtcg gcagcacaaa tattgataat 272821 aaaatattgc tgaagctggc gaaacgcatc aaccacttgc tcgcttcaga tgatgtagac 272881 ggaatcgtcg tgactcatgg aacagataca ttggaggaaa ccgcttattt tttgaatctt 272941 accgtgaaaa gtgataaacc ggttgttatt gtcggttcga tgagaccttc cacagccatc 273001 agcgctgatg ggccttctaa cctgtacaat gcagtgaaag tggcaggtgc ccctgaggca 273061 aaagggaaag ggacgcttgt tgttcttaac gaccggattg cctcagcccg atatgtcacc 273121 aaaacaaaca caactacaac agatacattt aaatcagaag aaatgggctt cgtcggaaca 273181 attgcagatg atatctattt taataatgag attacccgta agcatacgaa ggacacggat 273241 ttctcggttt ctaatcttga tgagctgccg caggttgaca ttatctatgg ataccaaaat 273301 gacggaagct acctgtttga cgctgctgta aaagccggag caaaggggat tgtatttgcc 273361 ggttctggga acgggtcttt atctgatgca gccgaaaaag gggcggacag cgcagtcaaa 273421 aaaggcgtta cagtggtgcg ctctacccgc acgggaaatg gtgtcgtcac accaaaccaa 273481 gactatgcgg aaaaggactt gctggcatcg aactctttaa acccccaaaa agcacggatg 273541 ttgctgatgc ttgcgcttac caaaacaaat gatcctcaaa aaatccaagc ttatttcaat 273601 gagtattgaa gaaaagaagg cgaataagcc ttcttttttt tggcttttta ggaccaataa 273661 tgacctctga atcttaaaat ttctttaaaa ataagccaaa attacccttt acttaattaa 273721 tttggtaacg taatataatt ggagaatttg ttacaaaaaa aggaggatat tatgaaattt 273781 gtaaaaagaa ggatcattgc acttgtaaca attttgatgc tgtctgttac atcgctgttt 273841 gcgttgcagc cgtcagcaaa agccgctgaa cacaatccag tcgttatggt tcacggtatt 273901 ggaggggcat cattcaattt tgcgggaatt aagagctatc tcgtatctca gggctggtcg 273961 cgggacaagc tgtatgcagt tgatttttgg gacaagacag gcacaaatta taacaatgga 274021 ccggtattat cacgatttgt gcaaaaggtt ttagatgaaa cgggtgcgaa aaaagtggat 274081 attgtcgctc acagcatggg gggcgcgaac acactttact acataaaaaa tctggacggc 274141 ggaaataaag ttgcaaacgt cgtgacgctt ggcggcgcga accgtttgac gacaggcaag 274201 gcgcttccgg gaacagatcc aaatcaaaag attttataca catccattta cagcagtgcc 274261 gatatgattg tcatgaatta cttatcaaga ttagatggtg ctagaaacgt tcaaatccat 274321 ggcgttggac acatcggcct tctgtacagc agccaagtca acagcctgat taaagaaggg 274381 ctgaacggcg ggggccagaa tacgaattaa tgaaaaacaa aaccttgaag aatgctattc 274441 ttcaaggtta ttctgctttc agcacaatgg ttttcgcagc catatcatga acggtttgtt 274501 ttttcttcgt aaatgcggca gtcaaataga tcaggcggga gaacacatgc acccacgcta 274561 tcaggtaacg gacaatggct tgcgggaagg atattttttt atatgtttcg tccctcacga 274621 tttgcagccc gatgattttt ttgcctagtg tgcccttcca atttgtcagc ggcatcagca 274681 aagggtacac aatcagcatc aatatggcga caataatgac accggcggac ccatcgccaa 274741 acgtaaatcc ggctgccaaa atcactgctg cggcaatgat tacatcaagt aaaagagcgc 274801 aggcgcgcag catgaaacca gctagttcca atagaaacac tccttaaaat gttaaataaa 274861 cacctaatga ttgtaaaaaa gaagggccta aagtgggaat aggtgataag ccttaaatca 274921 caaaagttgg tgaaaatgtc ataggtaaat tggcataatc agccagctta tcacattacc 274981 aaattctttt ttagcccgaa accaagccct cagaagttat ttttgttaaa atagaaaagt 275041 tacaacagaa ttcggagggt ttattgtggg aaaagtgaaa cgaaatgccc cttgcccatg 275101 cggcagcggc aagaaatata aaaaatgctg cggaagtaaa gttgtcgact tcccggcgga 275161 actagcggca aaagaagcga aacaaattca ggaagactta gtggagtatg ccttcacagt 275221 acatagagaa agcatttcag gctttatcaa ccagcatgat tttctttctg ctatggacag 275281 acagacgaaa gacatcagcg tatttaactt aggaatctgg ggaatcttct tccacccgct 275341 tgctggtgag aagacaatct tcgaagagta ccttcagaaa aaaggcgatt cgatcactcg 275401 tccgaaaacg cgtgagatcg tagaatcatg gcagagcatg acgcctgctt tattgctgct 275461 gaaggacctg aaggaaggca tcattcactt tgaagatgtc attacggcaa aacaattcga 275521 agtggaaatg gacgccagca atcaagacct tcctccagtg ggaagcctga ttcttggata 275581 cccaatccac gaagcggaaa aagcagaatt cttcatgcag ttcacgatct tcccggtgaa 275641 gagaacagaa gcgctgatca gcaaggtgaa gaaatatgcg gatgccgctg tgaaggacgg 275701 caaaacgccg gaggacttca tgaagcagga attcaacaac gttctgttcg cgttgttagc 275761 tgagaaagat gaagagccac aagcagagaa agcggaagta agcactgttg agtgggcaaa 275821 cgacttggag aaagaaaccg ctgcggctat tgaagaaggc atgagcgggg aagagtatcc 275881 gactgaattg atcccagctg ttattgacat ctggaaaaca ttctgcgaga aaaaatcacc 275941 tgtcatcaga aagccggaag cttttgcggc ggcagttgaa tattatgtaa acgcaatttc 276001 tcttaacggc gcgtccgttt cccaggctaa actggcgaaa aaatacggcg ttagcgcatc 276061 aacgatttcc agccgttaca aagaaattga aagcacgctg caagatgaag cagatcgttt 276121 tgcacaagcg ttatcctcat aatggaaaaa accttgaaaa gccaggcttt tcaaggtttt 276181 tttatttctg aaacggaatt ttgatttcta accggaagat ggggtggcgg taggtaaaat 276241 ccagcctgcc aaaagcgccc ttcaccagtt tttgaatgat atatgtgccc atgccttcat 276301 gagcgccgtt tttcgttgag cggccaaacg attgataaat tgtatcgagc acttttgggt 276361 ccatcccggg agtgctgttt tcacaagtca gtacataaag cccgctgcgc agtgaagtct 276421 ccagtttaat ctctgctttt tctcgggcct ccgccgcgct gtcgagcgca ttttctaata 276481 tgttgccgac caagctgacc tgatcagcag gcgaaaacgg aagggaagaa agcggtgtat 276541 gcatatgcag cgaaacactc acattcgagg cgcgggcttt ttctaaaaaa tcataaagca 276601 cccctgcaac gtacgcgttc tctcctttca aaaaacggtc atattggctg tattgatccg 276661 cccagttttg aatatatgct tgtgtatctg ccttgggctg agctgatttg attgcagtga 276721 tatgtttcat tgtgtcatga ttccggcttc tgacatcaat cagcatttga ttggcgtgct 276781 gttcagcttg agtcagctta tcaatttgat cagaaagcct tgcctgcaaa gcagactgtc 276841 cgatacggag cccttcacac cctgcaaata tcgcgattac acataatacc ggcatgatgt 276901 ctgtgccaat caacaccact cccaccgaca tcacttgaat caccgcaatc cacgcacaaa 276961 gccctgagga acagtgtttc cacacccgct tcgtattcca aatgtacaat cctgcagcag 277021 ctgcgcctaa agcagcggcg agccaagagg cggctgtgct gtgtgaaaaa gcagcagctc 277081 cctgataaca tatgaaacta aataaaatca gataaagaca ttgaaaaagg gtaatcacgt 277141 actaaactcc tcaaaaatag tagttttgaa aataatcaag ctgctgctta gtgatcatcg 277201 cttttttaga cgttccctca aaggaaactg tgaatgaatg cttggtataa gcggaaaaat 277261 gctttatgta atgaatgttg ataataaagg aacgatgcga acgaagaaaa tctttttcgg 277321 gcaggtcgcc tttaatatca tttaatgttt gatacgtttg cacctcttcg gcggttgtca 277381 caatcgtcgt cgaacgtccc gtccgttctg cgaaaataat atccttcttt tgcaggacgt 277441 gcatttcaga cttttgcttt atcaatatac gcccattcaa actcgtttcc gttttctttt 277501 tcaagtaccg gtcgaaggaa gcggccagac ggtcggcata gtacggcttc ataatataat 277561 catggacgtt caggtcaaag gcgtgaaccg cataaccgcc gtggccggta acaaaaatca 277621 catccacatc aagtgaatgg gatttgatca aatcagcaag ctcgtagcca gacatatggg 277681 gcatctcgat atcggcaagc agcagatcaa tgtctccgtt ctttacccgc ctgtaggctt 277741 ccttcgctga atcggtggaa aagacaattt cgacgtcctg cattctggac acgatcgctt 277801 ctaacttctc taaatctact cgataatcat ctacaagtcc gacttttacc attatcattc 277861 ccctagttac atagaatcat ctttattcta tcccatttca cgacataaaa agaactcttc 277921 gcgacaactt tatccaacta atccagcttt tcgtatatag tcattactag aaataaagat 277981 aagggagatt gtgacatgat tacactgacc gattgcagcc gcaggtttca ggataagaaa 278041 aaagtagtca aagcggtgcg agatgtaagc ttaacaattg aaaaaggaga agtcgtcggc 278101 attctcggag aaaacggtgc cggcaaaacg acgatgctga gaatgattgc ttccttgctt 278161 gaaccatcac agggtgtaat cacagtagac ggctttgaca cggtcaagca gccggctgag 278221 gtcaaacaaa gaatcggtgt cttattcgga ggagaaaccg ggctttacga caggatgacc 278281 gctaaagaaa atctccaata cttcggcagg ctgtatgggc tgaaccgcca cgagatcaaa 278341 gcaagaatag aagatttatc gaaacggttc ggcatgcgcg attatatgaa ccggagagtg 278401 ggcgggtttt cgaaaggcat gaggcagaaa gtcgccattg ccagagcgct gattcacgat 278461 ccggacatca ttttatttga tgagccgaca actgggcttg atattacgtc aagcaacatc 278521 ttccgcgaat ttatacagca gctgaaaaga gaacaaaaaa cgattctttt ctccagccac 278581 attatggagg aagtgcaggc gctctgtgac agtgtcatca tgattcacag cggagaggtg 278641 atttaccgag gggcgcttga atcactatac gagagcgagc gcagtgagga tttgaattac 278701 atctttatgt ctaagcttgt cagggggatt tcttaaatgc tgagccatat ttataaaaaa 278761 gaaatgatcg acgctttacg cgacagaaaa acgatattac tcacaatctt agtgccgatg 278821 attatgatgc ttggacttgt ctttttttat gaaagcatgc tgtccgacaa aggggagcag 278881 tacacgctgg ctgtcggcca ttcgcttccg cccgcactgg aaagcaagct taatgagatt 278941 gacgaaatca gcgtaaaaac atttgcaaag cctgaagagg cagttgatga aggaaaagca 279001 gatgcctatc tgaacgtccc gaaagagttc gactcatatg tcaacagcat gacacctttt 279061 aaggttgatg tttacggcaa ttcaatcgat caagggtcgt caaatgccat gcagcttgtg 279121 cagtctgcct tagatcagta caaaaatgaa attgtgcagc aacgtttaac aaataagcat 279181 attgatcaat cggtgatcca gccgtttaca attcagcaaa aggaagcgga tgaggagaaa 279241 gggacttccg ctattatgct ttccgccatt ctgcccatgc tgattctgac ttccattgtt 279301 tccggcgcaa tgccgatcgc tcttgatatc atggccggtg aaaaggaccg aaagtcaatc 279361 gaggcgctgc tattaacgcc agtcagcaga aacaaagtgc tggtcggcaa gtggcttgcg 279421 gtttccactt ttggcgtggc ttcaggtgta tttgctttgg tgtttttgat tttgtccacc 279481 gtgttattta ccgaaaattt aaaaacggcc ttccagctgg gagatcatat gtggagtgta 279541 atcggcgctt cagccttaat cattgtgctc tctgcattgc tgatatctgc gatggagctt 279601 ttcatcagca tcatgtccag ctcggtaaaa gaagcgcaaa gttatatgtc tctcgtcgtc 279661 tttctgcctg tgttcccgat gtttttcatc ttcagcaagg caccgaacca atttgactta 279721 tcatactttc tcatcccgtt tctgaacctg catgcgttat ttaaacagct tttattcggg 279781 atggttgacc cggctaccat tttgtctacg tcaggaacca tcgccgtgct catcgccatc 279841 ttctttttac tagccagagc ctgcttcctg aaagacaaat gggttcttcc aaaataaact 279901 tgcgaaagga gaaatacact ttctcctttt tgtatatcct gaaaaaagaa ggaaaataga 279961 aaaaggatat ctaatacaaa aagtgaccct gcactatttt tcatcaaaat tggtttcaaa 280021 ggagaaggaa caatggatca aacacgtaca ctcggcaaaa cgaagctgaa ggtgaagcgg 280081 atcggattcg gcgcgaatgc ggtcggcggg cataatctat ttccaaatct aaatgatgaa 280141 acagggaagg atttagtgcg cacggcattg gatggcggcg tcaattttat cgataccgcc 280201 tttatatatg gattggggcg atctgaagaa ttaatcggcg aagtcgtaca ggaacgcggc 280261 gtgcggaatg agctcatcat cgccaccaaa ggagctcata aagaagtgga cggcagcatt 280321 gaattagaca atagccggga gtttcttcgc agcgaggtgg agaagagcct gaagcggctg 280381 aaaacagatt acattgattt gtattatgtt cactttccgg atggaaaaac acctctcgct 280441 gaagtggcgg gcactttgaa agagctgaag gatgagggga aaatcaaagc gatcggcgct 280501 tcgaacctcg attatcagca attgcaggat tttaatgctg acggctattt ggaggtcttc 280561 caggccgaat attctctcat acagcgtgat gccgagaaag agcttcttcc atactgtgaa 280621 aaacaaggca tctcctttat tccttacttt ccgcttgcgt ccggactgct gacaggaaaa 280681 ttcacgcaag acacagtctt tgatgatttc agaaaggata aacctcaatt tcagggtgaa 280741 acgtttatcc acaatctcaa aaaagtagat aagctgaaag cagtagcgga ggaaaaacaa 280801 gcggatacgg cacatgtcgc cttggcgtgg ctgttaacga gaccggcgat tgatgccatt 280861 attccaggag ctaaacgacc ggagcaatta caggataacc tgaaaacctt gaacattgaa 280921 ctgaccgaag atgaagtgaa tttcatcagc gacattttca aataaaaaag gaaatagccg 280981 tcatggctat ttccttttgg tgttttattc tttgatgaat gcttcgacta attctgctgc 281041 tctgtaatca tccatatcaa gctgccattg gtcgatgtca tttttcttca ttttcacttc 281101 aactgttttt tcagatgaag caggtccaag ctttttgaat tcctcaggat agacttgaag 281161 cgcgtatttc actgcctctt catagctggc actagagttt ttactgtagt agtctttcac 281221 tttgtcttcg atgcggtctg aaagagaaga tgcatctaca ggtttaactg tggcttcaac 281281 aattgcttcg tctttagaga ttgaagtcgt ttttgcttga atggaagagt ttttgcttaa 281341 tccctcttta atgccgttca cgatattatc aagcgctttg ctgtccgcat atgtgctgga 281401 aaggccggaa gctgagagat aaccgtcttt ggctgattca ttaaaatcat ttacaatttc 281461 atttttgtta gcgccggtga ttttttcgaa atcggcgtta tctttgccga aaagaaggac 281521 atcaacataa gctgataacg cttttgcaga atcttggagc ttatctgccg tcgccaggat 281581 ttttttgtct tttccgtcaa ttttaaaagt aactgatttt ggctttttat caccgtaaga 281641 ttccggcgta tagttaagct cgtattgctt gcctttatct acaacgaaga aaagatttcc 281701 ttcaacggat ttgtcagcgt taatcgtgct gccctgaagc ttttcgctat agtcttcagg 281761 gtctgtgtca gacattttgg tatcaccttg atacaatgtg aaatccatac tgtctacatt 281821 cagcgggtct tttcctgtgt ttttcaccgc gacattgact tttaacacaa gctggtcatc 281881 tgaagtggac ttatcatatt tagacggaag tgtgtaagag acatccttga ttttgacttg 281941 agctatatct gagctttttt ctgtttctga ttctttcttc tccgcgcttg ttttgctgcc 282001 ggaacaagca gctgtaaaca tcatcagcag aagaattagg aaaacagcgt acgttttttt 282061 ctgaaacatt catttttcct cctcaaatgg tttaggaaag gggagtcttt tgtctttgag 282121 aaatggatct ttttgaatgg attagcatca tataaccaaa aaaatcagtt cttttctcac 282181 ggttttcacc ggattttctg gaaactccgc cctcctttgt catgaatgga cctataaaaa 282241 gttacaacgg aattaatttt aagattatta gcttttatat tgaataggtt catcatccta 282301 tttttggtga aaaatgttct ggtaaaactg gtaaactcag aaaactgtgt attttagact 282361 attacttttt gattagttgg agggaactta agaaggatga aaggggccgc ctttgtgaag 282421 aaagagggac tgaaacaaaa agcactggaa atcggccggg tgccgacaca cttaaaactg 282481 gaaattgaag attatggcgg tgatgataaa agagctcatt tttgttgggc agatcctcag 282541 gatgagaata ccggcattat cgtggagctt ggaccggacg gagagctgga atccctttcc 282601 cgtgatattg agcctgaaag cggagaaagg ctgtctgagg agaaactaga ggatatcatg 282661 cgccaatttg tcgagactca tcatccgggg gcactctctg cctttgttcg tgaagaaaat 282721 gaccgtgcat acggcgataa agtgagattt tcatatgttc aaatggaggc tgggcttcct 282781 ctccccatga gcggatttat ggctgatgtt tccttatcag gtgagattgt ttacttccgt 282841 tattacggcg aagcgggcag catcatcaag ccaaagcggg tcgcggatgt tgaagaggca 282901 cttgccttta tcaagaagga cgtggagttc gaccttttgt ttgaggttct ccatcgttct 282961 gtttacaaaa acggagatga tcagccgcat ttggtgtacg agcctgaagg tagggcgatt 283021 accgtacctg cggatttggt tcaagaagaa caagcagttg atgatgacga tgattacagg 283081 gagccggaga gctttcctct ccctttattc gagggcatcc gcgaaaaggc cgatcctgac 283141 agcatgattg gtattgaaaa tgggtttgtc aaagagcggg aagcggattt gggagatggg 283201 agaattggaa tcgtttggcg gaatccggat gaccctgtgt atcagccggc ggataaaagc 283261 atggacagct ggtttaaggg acggactcat caagtgctga aaaccatcta taacaaagaa 283321 accggaaaac tcgaaggcgt catgtcattt atggagaaaa aagggccgct gacagtaacc 283381 ttggcagagt gtgaaaaaat cgcgcttcgc tttctatttg ctttatttcc gaatgccgat 283441 caatatttta ggatcagata cgacgaaaaa gatgaagaag aaaacgcagt cgctggtttt 283501 acgtttgaag cgcattgtca cggagttccg ctccgatttg ggcagatcag aatttgtgtc 283561 agccgccaga cagggtatat caccgtttat atgggaccgg atattgaccc aaataagctg 283621 gcaaccattg atcctgtgcc ggctatttca gttgaacaag ccaagtctat cttttggcag 283681 cattttaaag ttgagcttgg ctgggaaaga gagtacgggg atgatgaaga acacagctac 283741 cggctcgtct ataagccggt gtatccgcat tttatcgatg cacatacagg ggagcctgtc 283801 ttcagcatat ggtgaaacag ccaaaagtca cgcaattgcc tcagatatag aagagagtat 283861 gtgatgaaag taacagaaag aatctcaaaa aacaatgaca ataatagaaa aggacctttc 283921 ttcactttaa atgaagaaag gtctttttat ataataaaca ggattctctt tgtcgtagac 283981 tctttgaaag ggatgacttc attggttaat aaacagctga aaaagaaggc gcaggagatc 284041 ggaaatgtac cgacgcatta tgagcttgag atagaagatt acgaccaaaa gcaaaagaag 284101 tacgggcagg catattttat ctggaaggac cctaaagatc cggaaaagca cattacagtt 284161 gaacttagaa atgacggcgc cttgctcacc ttttcaacaa ctgtccactc cgagacagac 284221 aaaaaacttc cagatgccga gctgaagctg acggctcttc agtttgccgc tgccaatcat 284281 cccggcacat ttatgaattt tcattttcaa ggcaaggaag aaagggggca gcacatccgg 284341 tttgtctata ccaaaatgga gctggggctt ccgattccca attcaggctt tttaattgat 284401 atgacacgaa gcggtcagat tgtccacttt ctatattacg gggaagggca taaagccgaa 284461 gttccgacgg aatttgtagc aaaagagaag gttgtatccc attacttaaa cacaatgtct 284521 tttgagctga tgtacgatgt cattgatggc gaacaggaac caaggcttgt atatgaaccg 284581 attctaccgg gatacagcta tcccgcagat gtagacgaaa ttgtgcccga ccagcatatc 284641 gcagatgaaa gaatagaaaa cacggcgcca ctgccgccgc ttcagaacaa ggaagaagtt 284701 gatatatttg ccttgctggg ttttacctct gatatgcaga aagtcagtga aagagacttt 284761 ggagaacaaa ttggaagcac gtggcgcagg ggcgctgcgc cggagcgtaa ggatttaagc 284821 ataggaagct attttgaaac gagaaataaa aatacaatca aaatgaagac ggataaaaga 284881 accggaaaat taaaagcagc gctttctttt atggactggc ggaacaacct ccaatgctcc 284941 acggaagaat gccaagagat agcgcttcaa tttttgtatg ccctctatcc gagagcggct 285001 gagtttttca gggtgaatcc cgtccgaatt gatgaaagag ggagagtccg caaccatttt 285061 tctgtctggt ataaaggagt gccgctgcgg ttcggcgctg cccgcatcat tgtcaatccg 285121 gaaactgggt tgattgacgc ttttatggcg cctgatattg aacctgaaca attggaagcg 285181 ataaatcaca ggccggatgt ttccgctgaa gaagcgaaag aagcattttt agccgctttt 285241 gatgtgaaac tggaatggca gcctgatttt acagcaggca gtgaccagca ctgcaaactt 285301 gtctataagc cggtttaccc ttcctatatt gatgcgcaca taaggaaaaa gaaaaggctg 285361 tgaggggtgt ctagttagga atcatctcca agtgggggta gtccttgaat cgtttccaat 285421 ccccgcccca ttcgaaaccg agtgtcttag cgatctcgac aacctccagc caatctgatt 285481 ttccgttttg attgccgtca tattccatat cccatatgat gctgccatcc tttttttgaa 285541 gggcgaaatc aatcgctaaa ccatagttat gatacgattc ccctcctctt gcataggtga 285601 caatattccc tttttttgta cgtccctgtt tatataattc atcttgttcc ttaaaggacc 285661 tgaatccttc agtaatgacg acgtcaatgc ctttattcgc tgcagcggct ttgagtgcat 285721 cggcattctg cttcacaatc ggatgaagat ccgaggggac aggcatgtcc tgcaaggcgt 285781 tttgagaatg ccattcatgc cgaatataac taaaacaaag atctagaaga aatagaatac 285841 ataagataac aaatgttttt gcgggtaagt tcatatcggt ctcactttct caagatgtgc 285901 tgaatgttaa cgcttttaag tgattgactc tctctaaaag cgaacagcta tgataaaata 285961 taacataaat agtagcagga ggaaggaggc agaccgatga gagcaaagat tccatcagaa 286021 gaagtagcag taaagctgaa tgaatggtac aagctcattc gcgcatttga agcagatcaa 286081 gcagaagcgt taaagcagga gattgaatat gatttagaag atatggaaga gaatcaggac 286141 ttgcttttat atttttcttt gatggaattc cggcatcgaa tcatgcttga taagctgatg 286201 ccggtgaaag acagcgatac caagcctccg ttctctgata tgctgaacga aattgaaagc 286261 aatcagcaaa aactcacggg cttactggaa tactactttt attatttcag aggaatgtac 286321 gaattcaagc agaaaaattt catattagcg attgaccatt ataaacatgc cgaggaaaag 286381 ctcgagtatg tcgaggatga gatcgaaaaa gctgagtttc tttttaaagt cgcagaagtg 286441 tattatcaca tcaaacaaac gtatttttcc atgaattatg cgagccaggc gcttgatatc 286501 tatacgaaat atgaactgta cggtcgccgc cgggttcagt gtgaatttat catcgccgga 286561 aatttgaccg atgtgtatca tcatgaaaaa gcactgaccc acttgtgcag cgctttagaa 286621 catgccaggc agcttgaaga agcgtacatg atcgctgctg cctattataa tgtcggacac 286681 tgtaagtaca gtctgggtga ttacaaagaa gcggagggct atttcaaaac agccgccgcc 286741 atttttgagg agcacaactt tcagcaagct gttcaagctg tattttcact gacccatatc 286801 tactgtaaag agggaaaata cgacaaggca gtagaggctt atgaccgcgg gataaagagc 286861 gcggctgaat gggaggatga catgtacttg acgaaattcc gcctcattca tgagctgtat 286921 cttggaagcg gcgacctgaa cgtgcttaca gaatgctttg acctgctgga atccaggcag 286981 cttcttgctg acgccgaaga tctgctgcat gatacagcgg aacgtttcaa tcagttggaa 287041 cattacgagt ccgccgcttt cttttaccgc aggctgatga atattaaaaa gaagcttgcc 287101 gagcagcgtt ttcaatagga aatggcagag aactacaggt tctctgcttt ttttgtgctg 287161 ttttcaactc ggaaaaacag ggtattttcc actgcatagt gagaaacaga ggaggatatc 287221 aagtatgtac aaagatttaa ccggaaaaac agcgattgtg acagggtctt caaaaggaat 287281 cgggaaagcc attgcggaac ggttcggaaa ggagaaaatg aatgttgttg taaattacca 287341 cagcgacccg tctggagcag atgaaactct ggaaatcatt aagcagaacg gagggaaagc 287401 cgtctcagtt gaggcggacg tgtcaaaaga agaggggatt caggcgctct tggacacagc 287461 tttagagcat ttcggcacgc tcgatgtgat ggtaaacaac tccggtttta acggcgttga 287521 ggcgatgccg catgagatga gtcttgaaga ttggcagaga gtgattgatg tcaatgttac 287581 cggaaccttt ctgggagcga aagcagcact taaccacatg atgaaaaaca atatcaaggg 287641 caatgtgctg aatatctcaa gtgttcatca gcagattccg cgccctgtaa acgttcagta 287701 ttccacatcc aaaggcggca tcaagatgat gacggaaacg ctggcgctca attatgcgga 287761 taagggaatc cgcgtcaatg cgatagcgcc cggcaccatt gccacagaat caaatgttga 287821 tacgaaaaag gaagagagca ggcaaaaaca attgaaaaaa atcccgatga aagccttcgg 287881 aaagcctgaa gaagtggcgg cagcagcagc ttggctcgta tctgaggaag caagctatgt 287941 gaccggcgca acacttttcg tcgacggcgg aatgacactt tatccatctc agcttgaata 288001 gaagacaaaa cagggggatt gcgggatgaa aacagactgg tggaaggatg cagtggtgta 288061 ccaaatttac ccgagaagct ttcaggacag caatggagac ggaattgggg acttgcgggg 288121 gattatttcc cgtcttgact acataaagga gctcggggca gatgtgattt ggatttgccc 288181 gatctatcct tctccgaatg ttgattacgg ctatgatgtg acaaaccata aggcgattat 288241 ggattcttac ggaacaatgg acgattttca cgagctgctg gaccaggtgc atcagcgggg 288301 attaaagctg gtgatggact ttgtgttaaa tcacacctcg gtcgagcatc cgtggtttaa 288361 agaagcggag ctggacaaaa acagcaaata ccgtagctat tattattggc gtcccggcac 288421 aaagaacggc ccgccgacgg actggctctc aaactatgga tgcccggtct ggcaatacga 288481 agagcacacc ggagaatact atctccatat gaatgccgtc aaacaagctg atttaaactg 288541 ggaaaatccc gaagttcgcc aggcggtgta tgacatgatg aaattttggc tcgataaagg 288601 ggtcgacggt ttgcgaattg atcagctcca tctcatttct aagaaagaat atcttccttc 288661 gtatgaggac tatatcaatc agcaggcaga gccgaagccc tttcagccaa atggcgaacg 288721 aatccatgac tatttaaaag aaatcacaga tgaagtgttt tctcattatg atgtcatgtc 288781 tgtcggagag gtcggcagtg tcacaccgga agaaggcctg aaatatacgg gaacagataa 288841 gcatgagctg aatatgattt ttcactttca gcatatggag cttgatcagc agcccggaaa 288901 agaacattgg gatttgaagc cccttgagct ttctgattta aaatcggttt tgacaaaatg 288961 gcaaaagaag cttgaacatc aaggctggaa tacattgttt tggtgcaacc acgaccagcc 289021 ccggattgtg tccagattcg gagacgatgg ggaataccgc aaagcatcag cgaaaatgct 289081 ggcagccgta atttatttta tgaagggcac gccgtatatt tatcagggag aagaaatcgg 289141 gatgacaaac gcgccgttca cccggattga agactacaaa gatatccaaa cgatcaatat 289201 gtatcataaa cgggtgtttg aaaaaggcta tgatccaaat gatgtgatga gatcgatctt 289261 agccaaaagc cgggatcacg cccggacccc gatgcagtgg aacagcggca aaaatgccgg 289321 atttactgac ggcacgcctt ggctgaaggt caatccgaac ttcaccgcaa tcaatgtgga 289381 ggaagcgcag ggagatcctg attctgtctt aaactattac aaaaagctga tcagcctgag 289441 aaagcagtac gctgacctca tgaaagggag ctttgatctt ttgcttccgg acgatccgca 289501 gttgtttgta tacatgagag aaaacagtaa acaacagctt ttgtcggtca ataatttttc 289561 aaaagagcag gctgtttttc agtggcctaa gaactgcggc aaagctcagg cctcactgct 289621 tctcagcaat tataacaacg atgatcttga tgacgaaatg gtgttccggc cttatgagag 289681 cagggtctat cttctggaca aaacaaacta atgattgaag tagcccggca tttttagccg 289741 ggttttttta gtacatatat tcgctctgca ggcgggaaga ataaatgaaa atgaaattta 289801 ttcttgcaaa acgtaatgac ttcggtttat tatgatatag gattacaaaa tcgttatcat 289861 tttgatttaa agttactgaa aaagagggga tatacgatat gtttaaaaaa tggagcggtt 289921 tgtttgtgat tgcagcgtgc tttttattag ttgcagcatg cggcaactca tcaacaaaag 289981 ggtcggcgga ttcaaagggt gataaactgc acgttgtcac aacgttctac ccgatgtatg 290041 aattcacaaa acaaattgta aaagacaaag gcgatgtgga tctgttaatc ccatcttccg 290101 ttgaaccgca tgattgggaa ccgacgccga aagacattgc caacattcag gatgctgatt 290161 tgttcgttta taatagtgaa tacatggaga catgggttcc gtcagctgaa aaaagcatgg 290221 gccaaggcca tgccgttttc gttaatgcaa gcaaaggcat tgatttaatg gaaggctctg 290281 aagaagaaca cgaagagcat gatcatgggg agcatgagca cagtcatgca atggaccctc 290341 acgtatggct tagccctgtt ctggcacaga aggaagttaa aaatattacg gctcaaatcg 290401 tgaagcagga cccggataac aaagaatact atgagaaaaa tagtaaagaa tatattgcaa 290461 aactgcagga tcttgataaa ctatatcgta caaccgcaaa aaaagcggag aaaaaagaat 290521 ttatcacgca gcatacagct tttggctatc tggcaaaaga atacggcttg aagcaggttc 290581 cgattgcagg gctttcacct gaccaagaac cgagcgcagc cagcttggca aagctgaaaa 290641 catatgccaa agaacataat gtaaaagtta tttactttga agaaattgca tcctcaaagg 290701 tcgcagatac gctcgccagt gaaatcggcg cgaagacaga agtgctgaat acactggaag 290761 gcttgagcaa agaagaacag gataaaggtt tagggtatat cgacattatg aaacaaaacc 290821 tcgatgccct gaaagattca ctattggtta aatcataaga tagtgtgcgc cggaggggtg 290881 cacactattt ctttgtgaga aaggaagatt aacatgaatc tcgtctcatt gaaagatatc 290941 gttttcggct attcccatac gcctgtttta gataaagtat cacttgatat tgaaagcggt 291001 gagttcgtcg gcatcactgg accaaacggc gcctctaaat cgacgctcat aaaggtaatg 291061 ctcggcatgc tgaaaccgtg ggaaggcaca gtgacgatca gtaaaaggaa tacagaaggg 291121 aaacgcctga ccatagggta cgtcccgcag caaatttctt catttaatgc cggatttccg 291181 agcacggtgc tggagcttgt tcagtcaggc cgctatacaa aagggaaatg gtttaaacgt 291241 ttaaatgaag aagatcatct tgaagtagaa aaagcattga aaatggtgga aatgtgggac 291301 ctccgccatc gtaaaatcgg tgatttatca ggcggacaga aacagaaaat ctgtatcgcc 291361 agaatgctcg ccagcaaccc ggatctgctg atgctggacg aaccgacgac agctgttgat 291421 tacgacagca gaaaaggatt ttacgaattt atgcatcatc tcgtgaaaaa tcacaaccgc 291481 acagttgtga tggttactca cgaacaaaac gaagtacagc aatttttaga taaagtgatt 291541 cgattagaga gaggagaaaa aggcggatgg aaatgtttga cttggaattc atgcgacgag 291601 cttttctagc aggcggcatg atcgccgtca tggctccgat actaggagtg tatctcgttc 291661 tcagaagaca ggccttaatg gctgacacac tttcacatat ctcattgtca ggtgttgcca 291721 tcggcttttt tctcagcacc aatataaccg cagcaagcat agtcgtcgtg accatcggcg 291781 cgatcggaat tgaatacatg cggcgggcgt atcggactta ttcagaagtg tccattgcca 291841 tcttaatggc agctggtttg tccttcgcga tgtttttaat cagcctttcc aaaggcacag 291901 ccaatatgag catcgatcaa tacctatttg gatcgcttgt gacagtaaac cagcagcagg 291961 tctatattat cagtattatc acactgctga tcctgcttta ttttattgta ctgagaaggc 292021 cgctctacct gctgacgttt gatgaagcta cagccaaaac atcgggaatc aatacaaacg 292081 ttctctcgtt gtcattcagt attgtcacag gccttgcgat ttcagtcatt attccgatca 292141 tcggggtcct tcttgtatcg gccctgctcg tattgccggc agccttcgcc atcagaattg 292201 caaaaggctt taacatggtt ttcattacag ccatactcat ttcattattc agcgtattta 292261 cgggactgac atcatcctat cagctcggga cgccgccagg tccgtctatt accctgctat 292321 tgatcgtttt gctattaatc ggatttgcag ttcagggagt ttggacgttt atcaaaaaag 292381 aagctcagcg caaaaaaaga agccgataac atgaaaagca gttttcccta gggaaaactg 292441 ctttttttat agaaacaatt cggcaaggcg ctcataagat tcttttttcg cctcaaaatc 292501 aaacacattg cacagaacca tgatttcatt tgtttcgtag cagcctgtga ggtctaacag 292561 ctgttgtttg acagtggtgg gagaaccgat caccatccgc tttctgtttt cttctatgag 292621 ttttttatcg gacgctgtat agggatgagc tttcgcttcc tcgatgcttg gcacgcggct 292681 gtccaagcct tttccgacgc gaagaagcca cagatcctgg cttaatgcga gttcttctgc 292741 ctcttcatct gtttttgcgc aaatgacaaa aatcgtaaac agtgcggatg gattcgaaaa 292801 atgggctgag ggccgaaagc tttcccggta gatgcggaat gcattttctc ctcgctcggg 292861 attaatgaaa tgcccaaata catatccaat cccctggtgc gccgcgcgtc ttgcgctgtt 292921 ttcaccaaga ccgagcaccc atagctcggg tgccgtacca ataaggggcg ccgctttgat 292981 tccggcatac ggatggtcgg gaggaaggga atctgttaga aaataagaga catcctgcag 293041 ctgtctgtta aattcggtta agcttttttt caccccgtcc gttaatgcaa gtctggtttt 293101 tgtcgtgccg ccgggggagc gaccgacgcc gaggtcaatc cggtttggat acagggcctc 293161 aagctggcga aaggtttcag ccactttaaa tgggctgtat tggggcagaa gcacgccgcc 293221 tgatccgaca cgaatggtgt ttgtctgtgc tgcgatgcgg gcgatcatga tttcaggcgc 293281 tgtgcttgcc agtcctttcg tgctgtgatg ctcggcaaac caataacgct tatagcccca 293341 ctgttcgctt aattgggcaa gctcaaccga atgctggaga gttgtcacag ggctttctcc 293401 tttagaaaca ggtgcctgat caagtatgct taaatgaatc aaaaggccgc ttcctttctg 293461 tctgttttta gatggtgaca ccagaatagg caaaatgact tgcccgcgtc aaatggtttg 293521 tttaagaagc gcactttata gcatttgcaa atcatatatc aaatatggaa gttttttttc 293581 gaggtttttc gtcaattatt cttaactttt acgaaacttt gatataataa caaacgtata 293641 tattagtaat ttacggctta ttttccttgt gagcgtaaaa ataaatgtga ctatcttcac 293701 attttgatga gtaggagtga atcgtgtggc aatttcttta gaaaaaggtc aacgaattga 293761 tttaacaaaa ggaaaagccg gtctgtcaaa attgatggtc ggtctcggct gggacccagt 293821 gtcctcaggc ggaggattct tcagcaaact gcttggcgga ggcggtccga atatcgactg 293881 tgacgcttca gtgctgatgc tggaaaacgg aaaattcacc gataagaaaa acctgattta 293941 tttcggcaac ctgaaaagcc gctgcggcgg tgtacagcat acaggcgaca acctgacggg 294001 tgacggtgcg ggcgatgacg agcaaattat gatagattta gataaagtgc ctggaaacat 294061 cgataagctt gtatttgtag tgaacattta cgattgtgtc agaagaaaac aagatttcgg 294121 catgattcaa aatgcgttta tccgcgtagt tgatcaatct aatcacgagg aaatgctcaa 294181 gtacaatttg agagacaatt acgccggcag aacaagcctg attacagcag aaatctaccg 294241 cagcggcagt gagtggaagt ttgcggcggt cggtgaaggc acaaacgata cgagattaga 294301 agatattatc agtcgatacg tataaaagaa aaggagtgga tgaaacatga caatttcatt 294361 ggcaaaagga caaaaagtag atttaacaaa aacaaatccg ggtctttcaa aggttgttgt 294421 cggtttaggc tgggatacga acaagtatga cggcgggcac gactttgatc ttgactcaag 294481 tgtgtttctg ttagacgccg cgggcaaatg cgcgtcacca aacgacttta ttttctacaa 294541 ccagcttgaa ggcggcaacg gttcagtcgt tcattcaggc gacaacctga ctggtgctgg 294601 cgaaggcgac gatgagaatg taaaagtaaa tctcagcgct gtaccggcaa acattgataa 294661 aatctcattt gttattacca ttcacgatgc agaagcgcgc agccaaaact ttggacaagt 294721 atcaaacgcg tttgtccgca tcgtaaatga agaaacaaat gaagagctca tccgttacga 294781 tcttgcagaa gatttctcta ttgaaacggc aatcattgca ggggagcttt acagacataa 294841 cggcgagtgg aaattctcag caatcggctc aggctaccaa ggcggccttg cccgcattgc 294901 aacagactac ggtttgcaag tcggttaaga caaatacgaa gagcagaaag gagagaggca 294961 gtatggccat tcaattatca aaaggacagc gcattgattt aacaaaaaca aatccgggac 295021 tgactaaagc ggtgatcggc ttaggctggg atacaaacaa gtactccggc ggacacgatt 295081 ttgacctgga tgcttcggcc tttttagttg atgcgcatga taactgcgta aatgatctcg 295141 atttcgtctt ctataataac cttgaacatc cgagcggcgg tgtcatccat acgggtgaca 295201 accgcacggg tgagggcgac ggagatgatg agcagattat cgttgatttc tcaaaaatcc 295261 ctgctcacat tgagaaaatc ggcatcacag tgaccattca cgacgctgaa gcacgcagcc 295321 aaaactttgg acaagtttcc aatgcatttg tccgcgttgt ggatgaagaa acgcagaatg 295381 agcttcttcg cttcgatttg ggagaagact tctccattga aacagctgtt gtcgtttgtg 295441 agctttacag acacggcggc gagtggaaat tcaatgcaat cggcagcgga ttttccggcg 295501 ggctggctgc attgtgccgg aattacggtt tgcaagtgta agcgagtgac aaatagagaa 295561 gtcaccgttt caaattatag gaggaaaaaa cttggacttt ttacatcata ttttgtctac 295621 gtatgcttca tttttcgatt ggaaaatgtg gggggaagtt ctgactgatc ctgtttcctg 295681 gggtttgatc ggttcccttg ttgttctgga aggcctttta tcggccgata acgcgcttgt 295741 tcttgcggtc atggttaaac acctgccgga aaaacagcgg aaaaaagcgt taacgtatgg 295801 tttgtttgga gcttatattt tcaggtttat tttcatcggg ctcggtatgc ttctcattaa 295861 attctggtgg atcaaggtgc ttggcgcgct ttacctggct tggctcgtca ttaagcactt 295921 ctggataggc gaaaaagaag aggaagcgga cggcatgaag aaaaactctt ggatggtccg 295981 cacgttcggg atcttctggg cgactgtcat ttcagtagaa ttaatggatc ttgccttctc 296041 tgtggacagc atcctggccg cgtttgcagt atctgaaaaa gtatgggtgc ttctgattgg 296101 cggtatgctt ggtattttaa tgatgcgtac agtggcaaaa gtgttccttg tgctgattga 296161 taaaattcct gagctggaaa acacagcatt cgtcttaatc ggcattatcg cgctgaaaat 296221 ggcggggagc gctttccatt acgaaatgcc gcactctgta ttcttcatta tcattatcgc 296281 tgcatttgcg gtaacattga tcattcacta catcaataaa caaaagcagg tgcgcgaaca 296341 aacagccgct tcaaaagaag aataaaacaa aacaaggagg gaggttcaat gtccttcctt 296401 ttttgttacc gaaatatcgt ttcaatgaca aaccggaaag gaggatatga tgagacaaga 296461 agaactaacc attcataaag cacttccggc tgatggcgat tggaaaagcc tgctgtttca 296521 gccattgccg gagcgggatc actatgaaac tgcacaaggc ctttcttttt ctcgtcttgc 296581 cggtcagata ttgggcacgc ctattgatga gacggactac tataacgagc tgtatgagct 296641 gtctgtaaac gaccgcataa cgattttgag tgaaacgctt gataaaacaa tcgaaccgga 296701 aacatttcaa aagcttcagc atattcattc catcaatcag aaagaaaaag ggctgtcagt 296761 cagccgcttt gttgcctttc tggacgggga aaagctgatt gcgaagcact caaatccctt 296821 gatgcaccgc catttaagaa aagcgttgat gacgctttta catacctttg cggacagtca 296881 tgaaaagggg ctgaatcatc ctgattttcg cagagtgctg cttgatgtct cgaagttttc 296941 cttaaaccat ctgaaccctt ggctggaaaa aaccgatata gagcgggaga tgccgaaggt 297001 tgtttggtat ggagatgcga cgaaaagcca gctctatttc ttatattatc tgatgctggt 297061 cggctgtgat gtactgctgt tccatccggc gggaacggat cagctggcgc ttgtcgaccc 297121 gaagcaggag ctcggtttta cggaaaagct cccggatgtt tcggagcttc agccgtttcc 297181 gaaagaaaaa ccagaccgga aatcaacagt ggcttaccgc tcaacaaagg aaattgaaca 297241 tgtgctgaat cacgaggaat ccatgctata taagccgtgg cagttcagag atcacacacc 297301 ggtgtccgtt acgctgaaaa cgacctatga tgaattgttt ttaatcacga aagaacgcgc 297361 ctttattcgg ccgaatttca aagctgataa acattccatt gagattccga atgtattcgc 297421 caaaattatg ggcgtgtcga aagacaataa ggaatattgg aacaggcttc atactctagc 297481 ggattatcag gaaacagaaa tggtcagaag ctttccattt acagaagaaa taaagtcgaa 297541 ctatcaattt cactacagcc acgcacttga tcaagaaggg aacattgatc cggacaagct 297601 gatggcaagc aatgtgtggc agtacaaaca gctgccggcg ggcgttcaga ctgccattgc 297661 caaaacgatt tcgagaatgt gcaggtaccc gcggcttaaa gccttgcatc aggaacaagt 297721 caaggatgtt caaatctatt tgtttaaaca aacaacaaac ctgcctgcta atctgctgaa 297781 attgattcaa atgttcgact atgcgcaaac cgttccgaaa ctcgttttat atcatacgga 297841 aatgagcggc ggactcacgc gttcggatgc tgccgccctg ctgttcctga atgaaatcgg 297901 aatcgatatc atcatttata atccgcccgg acaccaagat attgagcagt ttattgaaga 297961 ggatcagtat gatatccact ggctggatga catggtgttt cagcaggact acaaagagcc 298021 ttcgcttgtg aaaaggctct tcagaaccat tacccaaaaa taaggagaga agaaaagcat 298081 gacaacagaa aatcaaaatc cgcttgttct cgataaaaat gaagagattt cccagcaaaa 298141 agctgacgat atccgtcttc agctccgtca ggaaccagaa gtgaagcggc ttgctcaaca 298201 aattgacgtc aaaaaccaaa tggagctgct tgagtacggc aaggagccgg ccgttgaaat 298261 atccaagttc tctgaccgca tcttggggat gatgaaaaca acaagcgtga cagactccgg 298321 cacaatgctg actcagcttg ggaaaatcat ggaccgcttc gacaaaaatg attttgatga 298381 gccaaaggga ttaatggcga aaattttcaa acgcggcggc agcatgattg aaaaaatctt 298441 taaaaagtat cagacgcttg gcggagagat tgaaaaaatc cacgttgaga tttcaaaata 298501 caaagatgag atgacgaaga cgaactacac gctcgatgaa atgtatgaaa acaatatcaa 298561 atactatatg gagcttgaaa aatacgtcgt tgccgggcag atgaaactgg aagagatgca 298621 gtcgatcctt ccttcatatg aggaaaaagc ggcaagcggg aaccagctgg cgcaaatgca 298681 gctcgatacg ttgcgcaacg gcattcaggc gcttgaggaa cgggtgtatg atcttgacat 298741 ggcacggatg gtggcgcttc aaaccgcacc tcaaatccgt ctcctgcagc gaggaaatgc 298801 aaagctgatc gggaaaatca actccgcgtt tatcattacc attccgattt tcaaaaacgg 298861 cattattcag gctgttacgg taaagcggca aaagcttgtg gctgattcca tgagcgagct 298921 tgaccgccgg acaaacgaga tgctgaaacg aaatgctgaa aacatctcga gccaaagtgt 298981 tgaaattgcg agaatggccg gcagaccgag catagatatt gaaacgattg aatcgtcttg 299041 gaacacgatt gtcagcggca tgcaggaaac aaaacaaatc gaagaagaaa acaagcgcct 299101 ccgcgaagac ggcgcgagac gaattgccca gcttcaggat aatattaaaa aagcagcatt 299161 gcagcaataa taaaaacccc gcttgtggaa cataagcggg gtatttcaat tacatcattt 299221 agttaatgac aatgtgtaaa gacaggtgta aacttaaacg gtaatcattt tgcatatcag 299281 aggtgttggc aatgggaaaa caacagccta tatcccagcg taaactgctg ggcgtcgccg 299341 gtttggggtg gctgtttgat gcaatggatg tcggaatatt atcgtttatt atcgccgcgc 299401 tccatgtaga gtggaatctg tcgcccgaag aaatgaaatg gatcggaagc gtcaattcca 299461 tcggcatggc tgcgggtgcg tttttgtttg gtttgcttgc tgatcgaatc ggccgcaaaa 299521 aagtgttcat catcaccctt ttatgctttt ccatcggaag cggcatttcc gcttttgtga 299581 cgagcttatc ggcatttcta atccttcgtt tcgtgattgg tatgggactt ggcggcgagc 299641 ttccagtcgc ttcaacactc gtttcggaag cggttgtgcc tgaaaagcgg ggcagagtga 299701 ttgtgctttt ggaaagcttt tgggccgtgg gctggctcgc agcggccttg atttcttact 299761 ttgtgatacc aagcttcggc tggcaggctg cccttctgtt aactgcgctg actgcttttt 299821 atgcgctgta cctgcggacg agtctacctg attcgccgaa atatgaatcg ctttctgcca 299881 aaaagaggtc gatgtgggag aatgtaaaaa gcgtctgggc aagacagtat atacggccga 299941 cggtgatgct gtcgatcgtt tggttctgtg tggtgttttc ttattacggc atgttcctat 300001 ggctcccgag tgtcatgctg ctgaaaggct tcagcatgat tcaaagcttt gaatatgtcc 300061 tgctgatgac gcttgctcag ctacctggct atttctctgc cgcatggctg attgaaaaag 300121 cgggccggaa gtggatactc gtcgtttact tgattggcac agcaggaagc gcctatttct 300181 tcggaacggc ggattcctta agtcttctgc ttacggctgg agtgctgtta tcgtttttca 300241 atctcggtgc gtggggcgtg ctgtatgctt ataccccgga gcaatacccg actgcgattc 300301 gagcaacagg ttcaggaacg acagcagcgt ttggaagaat cggcggcatc ttcgggcctt 300361 tgctcgtcgg aaccctggca gcccgtcata tttcgttttc ggtcatcttt tcaatctttt 300421 gcattgcaat cttacttgcg gttgcttgta ttttgattat ggggaaagaa acgaaacaaa 300481 ctgagctaga ataggaaaag cacctcttaa aagaggtgct ttcagcgtgt cgacaaaccc 300541 tcgcattcgt tgtcaggact gcgcttcggt gctcaatgcg aagtggatca acggctaaat 300601 tctcaggcgt cctgcctaaa cgccgtcgtc atcacatcct gtgaatgtcc gctcctatgc 300661 tcgtccttcc tagacttcaa gggttttcaa tcacgctgaa aagattttgt caacaatctg 300721 aggcacctct tgaatgaggt gcttttttac aattgcgccc gggctgtgga ttggcgtttc 300781 ccggttttac tgattgtctg gtagagcgtc atagaaagta tgaacagaat ggcagtaaat 300841 cctgtgacag ctccgaaatg ctgtgtgctt tgatataaaa aacctgcaat acttgtaccg 300901 acagtggttc cggcatacat agcggcattg gaaagggaag cgatggttcc tcgcgcattt 300961 ggtgcaatgg attgaaagac acccatcatt aacggaaaga tgatgccagc tgtaaagaac 301021 gtgagaaaaa agccggcttc tactaaaaac aagtttggaa agaacggaag agcgaaatag 301081 agagcgccca ttagcagcat cccgctgatc agtgttttaa acatgcccag cttttctgaa 301141 acccggctgc cgataaggct cccgagcata tttcccagtc cgagtacaag catagctgcg 301201 ccaatttgtg acacggttaa atgataatcc gcggaaagcc aagtacccag aaagctgaac 301261 gatgcgaagt ttccggtttg aaacagaaaa taggcaagca gaatgaccga tgttttcggc 301321 aatgaaaaaa gctcccgata ggggttgaca attgatgggc gcgccaatgg ttcagaaggc 301381 cggatgccag gcatgaccgc cgccaggatc aatagaagaa taagcgagca cgctgacaaa 301441 acgaaaaatg gcgtatgcca tgtaaaggaa gcgagaaacc ctccaatagg aagtccgagc 301501 atttgtgaag cggccaaacc tgctgtcgca atccccatgc cttttatgat ctgagaaggc 301561 tggacaatga ctgggatgga cgcccaaatt tgaggcgtca caaacgcagc gctaacgcct 301621 gcggcaaaac ggaacaggca catggcggca aaagagggag cgatgccgca taaaaatgtg 301681 gatacgataa agcctgcaag tccccacagc atgactgttt tcctgttcag ccggtctgag 301741 attgggcctg caatgaaagc gaagagtgca taaccgagtg cataagcact gaccatccag 301801 cctgacaaat cagtagagac atgaaactga tcctgtaaaa gggggagaag cggcgaaagc 301861 aaaaaggtat ccgtgccaat gacaaacatg acactgaaga aaagccaaat gcgattcaaa 301921 ttttatcact cctattgttt tataacttta aaactatgaa acagatatgt atagagaaaa 301981 ccctttgtta gagggtttcc aaaaagccag gcaggtatgt ttgaaatgtg tcttcacgca 302041 gactgacgta ttttgtccgc gaatctttcc gggttgccgt caatcccgct tcacgcagcg 302101 ttttaaaatg ataagatgcc gtggttttga caatattgca cttttcacct acttcaccgc 302161 agctgagttc ttttccgctg acataaagcg tacgaataat ggcaagcctt gattcatcag 302221 acagtgcttt aaaaatttgc gctctgattt gatcatctga ttgtttcata gtcatgaaac 302281 tataatacat aatgggtgtt gaaaaagcaa cttatttttc cagtaaagga gcaggaagtc 302341 ataagaggaa ggaggaattc aattccaata aaagcgtttt caactaaagg taggagaaaa 302401 atcacccgta aaatacaatc atataggagg attacagagc atttagaagc ataaataaga 302461 tcatgtggtc acatggatgt ttataaagaa atggtacaga ataaaagaga atatgctgtt 302521 tgtgtgggaa gttacataaa tgttacggta ataaagattg cttaatatgg agggaaaata 302581 tgagtgtaga tgagaaacca attaagataa aagtcgagaa agtctctaag atttttggga 302641 aacaaacaaa gaaggcagtt caaatgcttg ccaacggaaa gacaaaaaaa gagatcctga 302701 aagcaaccgg atcaaccgtt ggggttaatc aggcagattt tgaagtatat gatggtgaga 302761 tatttgtcat catgggtcta tcagggagcg gtaaatcaac tttagtacgg atgttaaacc 302821 ggcttattga accgactgcc ggaaatattt acattgatgg tgacatgata acaaatatgt 302881 caaaagacca gctccgggaa gtccgccgga aaaaaatcag catggtcttc caaaagttcg 302941 ctctgtttcc gcacagaacg atacttgaaa acacagaata cggactggag cttcaaggtg 303001 tagacaaaca agagcggcag caaaaagcgc ttgagtctct taagctcgtt ggactggaag 303061 gatttgaaca ccaatatccc gaccagcttt ccggcgggat gcagcagcgt gtcggccttg 303121 cccgcgcgtt gacgaatgac ccggacatcc ttctgatgga cgaagcgttc agtgcgctcg 303181 atccactgat tcgtaaagat atgcaggatg agcttcttga tcttcacgat aatgtcggaa 303241 aaacaattat ctttattacg catgacttgg acgaagcgtt gcggatcggc gacagaattg 303301 tcctaatgaa ggacggcaac atcgttcaaa tcggcacgcc tgaagaaatc ctgatgaatc 303361 catctaacga atatgttgag aaattcgtcg aagatgttga tttgtctaaa gtcctcacag 303421 caggccacat tatgaaacgc gctgaaacag tgcggattga taaagggcct cgcgtagcat 303481 tgacactgat gaaaaacctt ggaatttctt caatttatgc agtggataaa caaaagaaat 303541 tattaggtgt tatctatgcg tctgatgcga aaaaagcggc tgagtctgat ttgtcacttc 303601 aagacatctt gaatacagaa tttacgactg taccagagaa tacgtatctg actgagattt 303661 ttgacgttgt gtccgatgcg aatattccaa ttgcggttgt ggatgagaag caaagaatga 303721 aaggaattgt cgtaagaggc gcgctgattg gcgcacttgc cggcaataac gagtatatca 303781 atgctgaagg cactaacgaa caaacacaag atccttctgc acaggaggtg aaataagatg 303841 gatagactgc ctagaatacc tttagcagat attattgacc gttttgttga ctggattacg 303901 atgacgtttg gcggattctt cgacggaatc gctaacggat tggccgcttt tgtaaatgga 303961 attgtcaccg gtcttggatt tattccatct attttgttaa cgattatttt cgccgcactt 304021 gcgtggtgga tcagtacaag gggaattgcg ttatttacgt tgattggatt cctcctgatc 304081 gattatttag gatattggga cccaatgctg caaacattgg cgcttgtttt gacatctgtg 304141 attatttcga ttgtggtcgg ggttccgatc ggaatttggg cgtctcagaa agaaacggtt 304201 cgccgtattg taacgccaat tcttgattta atgcagacaa tgcctgcttt cgtatatcta 304261 ttgccggcga ttttcttctt taacatcggt gttgtgccgg gtgttgttgc atctgttatc 304321 ttcgcgatgc cgccgacaat ccgcatgact gttctcggta ttaaacaagt gccggcggat 304381 ttgattgaag cgactgaggc attcggttct acaacagctc agcgtttgtt taaagttcag 304441 ctcccgcttg cgacaaaaac gattttggcc gggatcaacc agagcatcat gcttgcgtta 304501 tcaatggttg ttatcgccgc aatggtcggt gcaccgggac ttggttctga agtatacagt 304561 gccgttacac agctgaaaac cggggtcgga gtagaggccg gtatcgccat cgttatcgtt 304621 gccattaccc tggaccgtat tactcaaaat attaaagtga agaagaaaag cagggggaat 304681 gcctgatgct taaaaaaatc ataggcatcg gcgtttccgc catgctggcg ctctcacttg 304741 cggcttgcgg ttcagaaaac gatgaaaatg catccgcagc agaacaagtg aataagacca 304801 tcatcgggat tgaccccggt tcagggatta tgtccctgac tgacaaagcg atgaaggatt 304861 atgacctgaa tgactggaca ttgatttcag cgtcaagtgc tgcgatgacc gctacgctta 304921 aaaagtcata cgaccgtaag aaaccgatta tcattacagg atggacaccg cactggatgt 304981 tctccagata taagctgaaa tatctcgatg atccgaaaca atcttatggc agcgcagagg 305041 aaatccatac gatcacacgc aaaggcttca gcaaagagca gccgaatgcc gcaaagcttc 305101 tgagccagtt taaatggacg caggacgaaa tgggcgaaat catgatcaag gtggaagaag 305161 gcgagaaacc tgccaaagtt gctgctgagt acgtcaataa acacaaggat cagattgccg 305221 aatggacaaa aggcgttcaa aaggtgaagg gagacaaaat caaccttgcc tatgtggcgt 305281 gggacagtga gattgcaagt acaaacgtca taggcaaagt cttagaagac ttgggctatg 305341 aggtaacact tactcaggta gaggctgggc cgatgtggac tgcaattgcg acgggaagtg 305401 cggatgcatc cctttccgca tggctgccga atacccataa agcatacgcc gctaaatata 305461 aaggcaaata tgatgatatt ggcaccagta tgactggtgt gaagatgggg cttgttgttc 305521 ctcaatatat gaaaaatgtc aactcaattg aagatttgaa gaagtaatca aaaaagcagc 305581 ctgtgtcagg ctgctttttt tgcgttaaga agcgttagcg gcagcaagtg attccgcctt 305641 ctgaaatgtt ttgagcacgg cgttcgccaa aatatgaatg ccggtaaaca tcgcatttct 305701 gtcaaaggtc atgtgcggat gatggagccc cggctggagc ccgcagccta gtccgagcat 305761 cgttgttttc agattcggca ccttcacggc gtaaaaatgg aaatcctcgc cgccggtggt 305821 gacaagcggg tcatcaagcc gctcagcccc gatgatttcc gtaatggctt ctgccatgat 305881 cgcttcagct tctttatttt gtgttgccgc aggaaggctg tgttctttgt gcagctcgat 305941 ctttgcgcca aatgcagcgg cggccgcttc acaggctctt tctgtttcgg cgattaatgc 306001 ctccatggct tcattggtct gtgcgcgcaa atcaaggctg aacgatgctt ttcctggaat 306061 gatgttagag ctttcaccgc cggcttgcag ttttgtcatt ttgacggtat gcgggatttg 306121 cgggtcaata tgaatgagtc cgagcttgtg tacaagaaat gccgcaattt caatgctgtt 306181 tttcccgagg tgcggacggg cgccatgagc ctcttccccg atgatcgttc cctcaatgtg 306241 ctggcttgat ccgtgcagaa tagaaggagc gcagcggccg ttctgtgttt cctggatcgg 306301 acggacgtga acgccataca aatagtcgat atcatcaagc acgccttctt ctatcatttt 306361 caaggcgccg ccgccttttt cttctgccgg ctgaaagata aaacggattg tgcccttcgg 306421 aagctcaggt tgttttttta gcagcattaa cgtgcccaat gccattgtca tatgtgaatc 306481 gtgtccgcag gaatggttgg cgcgaaatgt gccgttaacc tcctgccaca gcgcgtcaat 306541 atcagcgcgt accgctacaa caggtgagcc tgagccgatt tcgccgacaa ccccggtgca 306601 gtctgaaaac gtgcgcgtcc ggcaccctaa atcctcaagc ttttgtttca aaaatgaagt 306661 tgtctcatat tccttccagc tgacttcagg gttcgcgtgc agatgctcga agatgtccat 306721 aatggtttgt ttcatttctt ctgaaagctt ttgcatggta agaaatacct ccttctatca 306781 gaatgaattt ttaccttctt tactttattt atattgaaac aggaagatag gctgtatata 306841 atatagcaca tattgctact attcagaata attaatattt tcaaacagag gggatggatc 306901 gaaatatgag tatgccagca gccgaaacac agcctaagaa aaaacgtatg acatttaaaa 306961 tgcctgacgc ctatgtcctc ttatttatga ttgctttcat ttgcgcaatc gcttcatata 307021 ttgtgccggc aggtgaattt gaccgcgtga caaaggggga tgtcacgacc gctgttccgg 307081 gaagctatca ttcaattgaa cagtctccgg tcagattgat cagctttttt acttctctac 307141 aggatggaat ggttggatca gcacccatca tctttctgat tttattcaca ggcggcacca 307201 ttgctattct agaaaaaacg ggtgccatca atggcctgat ttacaatgtc atcagcaaat 307261 tccgcacaaa gcaattatta tttatttgta ttgtcggcgc attgttctcc attctcggaa 307321 caaccgggat tgtcgtgaat tcagttatcg gttttatccc catcggcctc attgtggcac 307381 gatccttaaa atgggacgca gtcgcgggag ccgctgttat atacatcggc tgctacgctg 307441 gatttaactc caccatatta tcaccgtcac cgctcggttt atcacaatca atcgcggagc 307501 tccctctttt ctcaggaatc ggcctgcgag ttgtgatata catatgcttt ttgctgtctt 307561 ctattattta tatctatttg tatacgagaa aattaaaaaa atcaaaagat gccagtgtgt 307621 taggaacaga ttggttccct gcggcaggaa tgggcgaagc cggtaaagaa gaagatcagt 307681 cagtgccgtt taccgttcgc cataagctga ttttggctgt ggcgggactc tcacttgtcg 307741 gatttttata cggcgctttg aagcttggct ggtcagattc ccaaatggct gcgacattta 307801 tttttatttc tgtccttgcc ggtttaatag gcgggcttgc ggcgaacgat attgccaaaa 307861 ccttcattac gggctgccaa agtcttgtat acggggcgct gattgtcggg atggcacgaa 307921 gcatttccgt tatccttgaa aatggaaagc ttctcgatac tgtcgtcaat gctttggctt 307981 cacttttgga tggattcagc ccgattgctg gggcaatcgg catgtatatc gccagtgcgc 308041 tgcttcattt tctcatctct tcaggttctg gcgaagccgt tgtatttatt ccaatcctgg 308101 cgccgctcgc tgatttgatg ggaatcacga gacaggttgc ggttgaagcg gttatgcttg 308161 gagaaggggt cgtcaactgt gtgaacccga catccggcgt tctcatggcg gtgcttgccg 308221 ccagcggtat tccgtatgtc aagtggctgc ggtttatggt gccgcttgct ctgatttggt 308281 tcttgatcgg gcttgtcttt atcgtgatcg gagtcatgat caattggggg ccgttttaac 308341 gattgctgcc cgccggcttg tacggcgggc ttttgagtta ttcattgcag aagcgcaggc 308401 tgttattgta acatgtaagc cataagccat tcgtaaaagt gcgggaggaa ggtcatgaat 308461 aatctgcgta atagactttc aggcgtgaat gggaaaaata agagagtaaa agaaaaagaa 308521 caaaaaatct ggtcggagat tgggatgata gcgggagcat ttgcgctgct tgatgtgatc 308581 atccgcggca ttatgtttga atttccgttt aaagaatggg ctgcaagcct tgtgtttttg 308641 ttcatcatta tcttatatta ctgcatcagg gctgcggcat ccggaatgct catgccgaga 308701 atagacacca aagaagaact gcaaaaacgg gtgaagcagc agcgaataga atcaattgcg 308761 gtcgcctttg cggtagtggt gcttacgatg tacgacaggg ggattcccca tacattcttc 308821 gcttggctga aaatgattct tctttttatc gtctgcggcg gcgttctgtt tctgcttcgg 308881 tatgtgattg tgaagctggc ttacagaaga gcggtaaaag aagaaataaa aaagaaatca 308941 tcttttttgt ttggaaagcg agggaagcgt tcacagtttc gggcagcttt ttttatagga 309001 acattgattt gtattcactc tgccaagttg ttttgataga gtgattgtga taattttaaa 309061 tgtaagcgtt aacaaaattc tccagtcttc acatcggttt gaaaggagga agcggaagaa 309121 tgaagtaaga gggatttttg actccgaagt aagtcttcaa aaaatcaaat aaggagtgtc 309181 aagaatgttt gcaaaacgat tcaaaacctc tttactgccg ttattcgctg gatttttatt 309241 gctgtttcat ttggttctgg caggaccggc ggctgcgagt gctgaaacgg cgaacaaatc 309301 gaatgagctt acagcaccgt cgatcaaaag cggaaccatt cttcatgcat ggaattggtc 309361 gttcaatacg ttaaaacaca atatgaagga tattcatgat gcaggatata cagccattca 309421 gacatctccg attaaccaag taaaggaagg gaatcaagga gataaaagca tgtcgaactg 309481 gtactggctg tatcagccga catcgtatca aattggcaac cgttacttag gtactgaaca 309541 agaatttaaa gaaatgtgtg cagccgctga agaatatggc ataaaggtca ttgttgacgc 309601 ggtcatcaat cataccacca gtgattatgc cgcgatttcc aatgaggtta agagtattcc 309661 aaactggaca catggaaaca cacaaattaa aaactggtct gatcgatggg atgtcacgca 309721 gaattcattg ctcgggctgt atgactggaa tacacaaaat acacaagtac agtcctatct 309781 gaaacggttc ttagacaggg cattgaatga cggggcagac ggttttcgat ttgatgccgc 309841 caaacatata gagcttccag atgatggcag ttacggcagt caattttggc cgaatatcac 309901 aaatacatct gcagagttcc aatacggaga aatcctgcag gatagtgcct ccagagatgc 309961 tgcatatgcg aattatatgg atgtgacagc gtctaactat gggcattcca taaggtccgc 310021 tttaaagaat cgtaatctgg gcgtgtcgaa tatctcccac tatgcatctg atgtgtctgc 310081 ggacaagcta gtgacatggg tagagtcgca tgatacgtat gccaatgatg atgaagagtc 310141 gacatggatg agcgatgatg atatccgttt aggctgggcg gtgatagctt ctcgttcagg 310201 cagtacgcct cttttctttt ccagacctga gggaggcgga aatggtgtga ggttcccggg 310261 gaaaagccaa ataggcgatc gcgggagtgc tttatttgaa gatcaggcta tcactgcggt 310321 caatagattt cacaatgtga tggctggaca gcctgaggaa ctctcgaacc cgaatggaaa 310381 caaccagata tttatgaatc agcgcggctc acatggcgtt gtgctggcaa atgcaggttc 310441 atcctctgtc tctatcaata cggcaacaaa attgcctgat ggcaggtatg acaataaagc 310501 tggagcgggt tcatttcaag tgaacgatgg taaactgaca ggcacgatca atgccaggtc 310561 tgtagctgtg ctttatcctg atgatattgc aaaagcgcct catgttttcc ttgagaatta 310621 caaaacaggt gtaacacatt ctttcaatga tcaactgacg attaccttgc gtgcagatgc 310681 gaatacaaca aaagccgttt atcaaatcaa taatggacca gagacggcgt ttaaggatgg 310741 agatcaattc acaatcggaa aaggagatcc atttggcaaa acatacacca tcatgttaaa 310801 aggaacgaac agtgatggtg taacgaggac cgagaaatac agttttgtta aaagagatcc 310861 agcgtcggcc aaaaccatcg gctatcaaaa tccgaatcat tggagccagg taaatgctta 310921 tatctataaa catgatggga gccgagtaat tgaattgacc ggatcttggc ctggaaaacc 310981 aatgactaaa aatgcagacg gaatttacac gctgacgctg cctgcggaca cggatacaac 311041 caacgcaaaa gtgattttta ataatggcag cgcccaagtg cccggtcaga atcagcctgg 311101 ctttgattac gtgctaaatg gtttatataa tgactcgggc ttaagcggtt ctcttcccca 311161 ttgagggcaa ggctagacgg gacttaccga aagaaaccat caatgatggt ttcttttttg 311221 ttcataaatc agacaaaact tttctcttgc aaaagtttgt gaagtgttgc acaatataaa 311281 tgtgaaatac ttcacaaaca aaaagacatc aaagagaaac ataccctgga aggatgatta 311341 atgatgaaca aacatgtaaa taaagtagct ttaatcggag cgggttttgt tggaagcagt 311401 tatgcatttg cgttaattaa ccaaggaatc acagatgagc ttgtggtcat tgatgtaaat 311461 aaagaaaaag caatgggcga tgtgatggat ttaaaccacg gaaaggcgtt tgcgccacaa 311521 ccggtcaaaa catcttacgg aacatatgaa gactgcaagg atgctgatat tgtctgcatt 311581 tgcgccggag caaaccaaaa acctggtgag acacgccttg aattagtaga aaagaacttg 311641 aagattttca aaggcatcgt tagtgaagtc atggcgagcg gatttgacgg cattttctta 311701 gtcgcgacaa atccggttga tatcctgact tacgcaacat ggaaattcag cggcctgcca 311761 aaagagcggg tgattggaag cggcacaaca cttgattctg cgagattccg tttcatgctg 311821 agcgaatact ttggcgcagc gcctcaaaac gtacacgcgc atattatcgg agagcacggc 311881 gacacagagc ttcctgtttg gagccacgcg aatgtcggcg gtgtgccggt cagtgaactc 311941 gttgagaaaa acgatgcgta caaacaagag gagctggacc aaattgtaga tgatgtgaaa 312001 aacgcagctt accatatcat tgagaaaaaa ggcgcgactt attatggggt tgcgatgagt 312061 cttgctcgca ttacaaaagc cattcttcat aatgaaaaca gcatattaac tgtcagcaca 312121 tatttggacg ggcaatacgg tgcagatgac gtgtacatcg gtgtgccggc tgtcgtgaat 312181 cgcggaggga tcgcaggtat cactgagctg aacttaaatg agaaagaaaa agaacagttc 312241 cttcacagcg ccggcgtcct taaaaacatt ttaaaacctc attttgcaga acaaaaagtc 312301 aactaaccgc aactttagag taaagggctg attgtcaatg tgggagcagt tgtatgatcc 312361 gtttggaaac gagtatgtga gcgcacttgt ggcgctcact ccgattctct tttttctttt 312421 ggctttaact gttttgaaaa tgaaaggcat tcttgcggca tttcttaccc tagccgtcag 312481 tttcttcgtc tccgtttggg catttcatat gccggttgaa aaagcgattt cttctgtttt 312541 gttaggaatc gggagcgggc tgtggcccat tggctacatc gtcctgatgg cggtgtggct 312601 gtataaaatc gccgtgaaaa ccgggaaatt taccattatt cggtccagca ttgccggcat 312661 ttcgcctgac caacgattac agctattatt aattggtttt tgttttaacg cgtttttaga 312721 aggcgcggcc ggttttggtg ttccgattgc gattagtgcg gcgctgctcg tcgaacttgg 312781 ttttaaaccg ttaaaagcgg cggcgctctg cttgattgca aacgctgcct ccggagcctt 312841 tggggcgatt gggattcctg tcatcacagg ggcgcagatt ggtgatttgt ctgctcttga 312901 gctgtctcgg acattaatgt ggacactgcc gatgatctca tttttaatac cattcctgct 312961 tgtattctta ttagaccgaa tgaaaggaat caaacagaca tggcccgctc ttctggttgt 313021 gagcggtggg tatacagcgg ttcagacact gacaatggcg gtgctcgggc cggaattagc 313081 aaacattttg gcggccttat tcagcatggg cgggcttgcc ctcttcctcc gcaaatggca 313141 gccgaaagag atttaccgcg aggaaggggc cggcgatgct ggtgagaaaa aggcataccg 313201 tgccgctgac attgcgaaag cgtggtctcc tttctacatt ttaactgcgg cgatcaccat 313261 ctggagcctt cctgccttca aagcgctttt ccaagaaggc gggctgttat atcaatcaac 313321 gctcctgttc aaaatgcctt ttctgcatca gcaaattatg aaaatgccgc cgattgcgcc 313381 atctgccatg ccgttagatg cagtctttaa agttgatctg ctgtcagcga ctggtacagc 313441 gattttagcg gcggtcatcg tgacagggct gttcagcaaa aagttctcct ctcgggatgc 313501 ctttgcttcc ttgaaggaga cgggaaaaga gctgtgggtg ccgattatga cgatctgctt 313561 cgtgatgggg tttgccaatc tggccaactt cgcagggctc agctcttcaa ttgggttagc 313621 attggcgaaa acaggagacc tgttcccgtt tgtcagtcct gttctcggct ggattggcgt 313681 gttcatcacc ggttctgttg tcagcaataa tgctttgttc ggccatttgc aggttgtcac 313741 gggagcgcag atcggtgcgg gttcagattt gctgttagcc gcaaatacgg cgggcggtgt 313801 catggcgaaa cttgtttctc ctcaatctat cgccatcgct gccgcagcgg tcggccaaac 313861 aggcaaggaa tctaaactgt ttaaaaggac agtggcgtac agcctgattc tgttattgat 313921 catttgtata tggacgttta ttcttgcaag attaggagtg taatagaaaa aagcagtaca 313981 tgcccagcat gtactgcttt ttttatgtta atttgctttc tttgtcattt cggctgttgt 314041 tttcactctg gcttttccca taaataaaat ggtaaccgcc gcgaggacaa ttggaatcaa 314101 agcgagcaaa aagacatacg tgatacttga tgacatcgcg tcaataatgc gattcaggat 314161 cgcatcagga atctgggaac gtgttcccgc ttggaatatc tcctgcgggt cgccaatatt 314221 ttgcgcagcg cctgatcccg ctgagccttt cataccgctg aaggcgtcat tcagcttgtt 314281 tgtgaatacg tttgtttgca ccgttccgaa aatggtgaca cctaaggtca tgccaaatga 314341 tcgcaaaaat gaatttgtag agtttgccgt tccccgaaag cgaggttcaa gatcattcat 314401 cgatgccgcc ggcagcaggg agaagttaaa gcctacacca aagcctgaaa tcatcataaa 314461 gactgtcagc catacccgtg ctgtgtcagg cgtcatattg gaaagaagca gcatgccgat 314521 aaagaaagct ataacagata tcagcatcaa attgcggaag cttgccttcg tttggaagat 314581 cccgccgatc atgcttccga tgactgatcc aatcatcatc ggcgtcagaa tgaagcccgc 314641 gcttgtcgcc gagctgccgt agaccgcctg aacgaaaatc ggaataaata ccgctaaaat 314701 aataaatgtt ccgccataca ggaaagcgag aatctgtgct gtggcaaaca agcggttctt 314761 aaacatccag aaagaaataa tcggctcttc tgcttttctc tccacaataa aaaaggcaat 314821 gaagaaaacg gcgaatacaa taaacagccc gatgatctga atggagttcc aatcgtatgt 314881 tttgccgcca agctcaaggg cgaacatcag gcatacaatg gatacgacta aggtaatcgc 314941 gccgccccag tctattttct gctttctgtg ctccagagat tctttgtagt agcgaataat 315001 gaaaaacaat gacaatgcgc cgatcggcac attgatgtaa aacacccagt gccagctgat 315061 cgaatctgta atgatcgcgc ctaagagcgg accaagaaca ctggataatc caaatacagc 315121 accgaacatg ccggacattt ttccgcgttt ttccggcgga aacaaatcaa agataatggt 315181 aaaggcaatc ggcaggagcg cgccgcctcc gatcccttga atggcccgga agatgatcag 315241 ctgattcatc gtctgggcaa tcccgcataa agcagaaccg attaagaaaa aaataagtcc 315301 aaacaggaaa aaacgttttc ggccgtacat atcggaaagc ttgccgtaaa tcggcatgcc 315361 agccataacc gccaccatat aggatgccgt cacccaggca aatttatcga agcttccaag 315421 atcggctacg atattgccca tcgcggtggc aacaatcgta ttgtccattg cagacatcaa 315481 gatgcccagc aggagaccga ggaccacaaa tttggtggaa gcctgttttg ctgttgttgt 315541 gtccatttgt tctacctcct cttacttttc tatgtaagtt ctgatatcat gataatagtt 315601 tgattgttga atatctcgat tatcaagata aactcgattt tatagggagg actgtcagtt 315661 gtcaacaaga aattccagaa gtgagttgga aaagactgct gttcagcttt ttcgaaaact 315721 gggcacaaga acggttctgt ttcatcaggc agccgctcaa gctctcggtc tgtttcccac 315781 cgatttgaaa tcagctgaca ttttaaatga agcagggccg atgacggccg gagagctggg 315841 gaaaaaaacc ggcctcagca cgggttccgt cacggcgctt gttgaccggc tggaaaaagc 315901 ggggtatgtg gctcgtgaaa aggacccgaa cgatcgcagg agagtcgtaa tcgtcccttt 315961 gactgcttcg aaaaaacata taaaggattt gttccgtcct ctgtctgagt caacgatgga 316021 tttgtgccgc gaatatacgg aagaggagct ggaactcatt ttcagttttg taggcaaagc 316081 tgccgatatt atggaggaag agcttgaacg tctgaaacag taagtgaatt tgtgcatagc 316141 ttggcccgtt cccgaataaa ttgtacaagt tacataagag aagggagtac gggccggtga 316201 acattttttt gagctatatt gtgctgggac tgtccttgtc tgcgcctgtg gggccagtga 316261 atgcggcgca aatagacaaa ggaattaaaa acggtttttg gcatgcatgg attttcggtt 316321 taggcgccat gacagcggat gggctgtaca tgctttttat ctatttcggg ctgtcgcagt 316381 tcttgaccgc tccatttgtg aaaacgtttt tgtggctgtt cggctttttt gtcctgacct 316441 ataccggaat tgaaacgctg aaaaacgtca gagaaccgat ggatgtgcga agctcgcggg 316501 ggaaaccgtc atacaggaaa acattcgcat cgggttttct catttcattg tcaaacccat 316561 tgagcatcct tttttggctt ggaatttacg gaagcattct tgcgaaaaca gcagaggcct 316621 acaatatgaa tcagcttcta atctatagct ccggcatcat gatcggcatt ttaatctggg 316681 atttctgcat ggctatcaca gccagtacgt tcagaaacct gcttcatgaa aagctattga 316741 gaggattgac cggaatcgcc ggtgtatccc tccttgtgtt tggcttttac tttggttatc 316801 agggcatcaa acagttattg ggctgattca tgaaggacag tcacctgccg cttccagttt 316861 taatatagta tccagatgat actggaggtg gatcaatggt gaatgggatt tacaccaaaa 316921 gttttctgga acgtattcag gaagagcttc ctgaatggca aagaatcgct tttgagctgc 316981 tggcagaaac tctgggggac gacgcggata catttccgtg cattcccgga cgccaggcgt 317041 ttctgactga tcagcttcgg attgcttttg ccggagatcc gcgggaaaac cgcacagcgg 317101 aggaactggc tccgttgctt gcggagtacg gcaagatatc gcgggacacg ggaaaatacg 317161 catccctcgt tgtgttgttt gatacaccgg aagatttggc ggagcattat tcgattgaag 317221 cgtatgaaga gctgttttgg cgctttttaa atagactgag tcatcaagac gaaaaagaat 317281 ggccggaaga cattccggcc gatcctgagc attataaatg ggagttttgt tttgacggcg 317341 agccgtattt cattctgtgc gctacaccgg ggcacgaggc aagaagaagc cggagctttc 317401 ctttttttat ggtcacgttt cagccaaggt gggtgtttga tgacctaaat ggatcaactg 317461 catttggccg taacatgagc aggctgatcc gatctcgttt agaggcctat gatcaggctc 317521 cgattcaccc gcaattaggc tggtacggag gaaaagataa tcgtgaatgg aagcagtatt 317581 tcctccgtga tgacgaaaaa caggtatcga agtgcccgtt ttcttattta aagaacatgt 317641 tcaacaaaat gaaataaatc aaggactggc agggcgatct ttatgaccct gctttttttg 317701 atagatcatg gtaacgatgg cgataatcac gagaaaacct atgctgacga aaaaaccggg 317761 ccggcttgat ttttcaaaca atgtaccgga cacagctgca gcaatcagaa ccatcgctaa 317821 ataaatttgc gtttttccca tgccctcggg atcagtcagc tttttgctgg agaacaggat 317881 aaacagccaa gtgtataaaa gcataagccc cgcagctgtt gtcatatgct cataaatgtt 317941 tttaggcagc actaacgaca aaataatgga gaggacaagc cccgcaaacg tcagcccaag 318001 tgccggccag catatttttt tgccttcctt tagagtaaag catttcggcg cgtcgccgtc 318061 atcagccatt gtacaaagca atgtcgtaac cgcaaatagc gaagcgacaa gggtcgagaa 318121 ccctgcgatg atgaaaatcc cgttaaatat atcaaggatg atctcaaggt tatatccttt 318181 taatgacgta atgaacggac tgtcctgttc agtaaacgtg tgtaacggaa ccaaaagcag 318241 agcaagcccg attgaaatga tataaataat cgccagcgtc gccagcatca gtttccctga 318301 tttagacgct tcctcaggtt tttttaagtg aaccgccatc agccccatga cctcaattcc 318361 gccaaaagcg taaaacgcgt agattaaacc tgtccacagc cccatggcgc cgtatgggaa 318421 aaactcactc gtcttatttg gaacatgtat gccatgattt ccgccggaca ggataccgca 318481 taaagccagg atggcaatga caataaacat aaaaatagca gctgttttaa tgactgccag 318541 cacgttttct gttttttcaa agacggacag gccggtgaaa ataataagga gcccaagtac 318601 tgcgtagatt gaggcaaaca cccatagcgg cacttgagga aaccaatgct tcgtaaagag 318661 cgaaatggct gtcagctggc ttccggtaat cagcatttct gatgtccagt acacccagcc 318721 gttgctgaag cctgcccatt tgccgaatgc ttttcgggca tacgcacaaa acgagccctt 318781 ttccggctgc ttcgccgata gcttggcgag ctgttcaaag acaaaatacg taccgatccc 318841 tgcgatcaga aatgaaagga gaacggaaaa accgcttttt acaattgcga tgctggaacc 318901 gagaaagaag cctgttccaa tcgtgcagcc gactccgatc agtgacagct gccaccaagc 318961 cagattccct tttggctggt ctttttttgt ttggctcatt atttattcaa ccccttttat 319021 ctaaggttag attgtgatct gtccaaagct tatatacatc ggatttttgc ctctttttac 319081 atggagaagg aagcagacgc tcatactaat gaaaaaagga gcaaaccaat gacacagcaa 319141 tatattgtgg agccgaaaaa agggcttggg ctgaagctga aaaaggggca gattttaaag 319201 gtggttgatg tagaagggca gcaggtggct gattttgtcg cataccatgc caaggatttt 319261 tatgaacacc ttgatcaggg agcgacgata gacgccaatc actccattca tgtgaaggtc 319321 aacgaccatc tctactccaa cctgtataag ccgatgttaa ccctgattga agatacggtc 319381 ggcaagcatg atctgctgtt gcccgcctgc cgtcctgata tgaacaggct cttatatggg 319441 aagcaaaagg atgagtttca ggatacgtgc tatgacaata tgaaccgtgc gcttgagcag 319501 tttggcgtac cgaagcccca catgcattac ccatttgcga tttttatgaa tactgtcctt 319561 gatgagaaag ggaatctgtc tgtggaaacg ccgctttcga atgccggaga ttatgtaagg 319621 ctcagggcgg agatggattt aattgtcgcg ttttcttcct gcccgattga aaaagggaaa 319681 tgcaatggcg acagtgtgac atccatacgg gttgaagtca gctgatctct cttgttcaca 319741 gtgaatgaag acctgtgcta tatttaatag ggatacataa cagtcatgat tcattttcat 319801 tgatttaggg aaatgatcag taataaggga aaatgtacag gaggaatgat tgggatgagc 319861 atgcaggaaa agattatgcg tgagttacat gtgaagccct caattgatcc aaagcaagaa 319921 attgaggacc gagtcaattt tttaaaacaa tatgtaaaga aaaccggtgc taaaggcttt 319981 gtattgggaa tcagcggggg ccaggattca acacttgcgg gaagactcgc tcagcttgcg 320041 gtggagagca ttcgcgagga gggcggagac gctcaattta tcgcggtccg tcttccgcat 320101 ggcacacagc aggatgaaga cgatgcccag cttgctttga agtttattaa gccggataaa 320161 tcatggaagt ttgatattaa atcgacagtc agcgcttttt ctgatcagta tcagcaggaa 320221 acaggcgatc agctgacgga ctttaataaa ggaaacgtaa aagcaagaac aagaatgatc 320281 gcgcaatacg cgatcggcgg ccaggaaggt cttcttgtgt taggaacaga ccatgctgct 320341 gaagcagtga ctggtttctt tacgaagtac ggtgacggcg gagcagacct cctgccgctg 320401 acaggcttga cgaagcgcca gggaagaacc ttgctgaaag agctgggtgc accggaacgc 320461 ttatacttaa aagaaccgac tgccgatctg ctcgacgaaa aaccgcagca gtcggatgaa 320521 acagagcttg gcatttccta cgacgagatt gacgattatc tcgaaggaaa agaagtatca 320581 gcgaaagtat cagaagcgct ggaaaaacgc tacagcatga ctgaacataa acgccaggtt 320641 ccggcgtcta tgtttgatga ctggtggaaa taagttgaag aaagcccgct ctcggagcgg 320701 gcttttgtcg tgtacagaag ctttatttga tgcggatatg attcagcttt accattaatc 320761 tgtcggcgaa ccttcggagg ctgcctcttg tatcaggatc taatgggagt tcggctctcg 320821 cggcaatgtt ctctgccaca tcctgaatcg acaggttgtc tgtttgaatg tggtcctcaa 320881 aaatgggtga tgataatcct tcaacacagc ggtcaatttg tttggcggcc catgagtttt 320941 ttccttctgc tctggtgcgc agccttttta acaaggtttc ctttgaagcc attagtgtaa 321001 agtggtgaac gatcctgcct tcctgtctga gcctgccgat gatctcattg aagtattcag 321061 ggtgtacaat cgtcataggc acaataagga tgccgcggta tgtatctgtc agagaagcta 321121 gcaaactgta attgaacgcc cgccataaag gatagctttg aaaatcgtcc tttgcgatct 321181 cctgcggcac catggagcgc agcgcaaaac ccattttctc gggatcatac acgtaagatg 321241 ggttcagcct tctgtgcagt tcgaaggctg tttgtgtttt tcccgaaccg aatgccccgt 321301 ttatccaaat gatcatcgcc atttctccct tcctatttat catacagaaa aagacccttc 321361 catcgaagag tcagctggaa aaacaataaa ggcggaaggt tttaacgctt ttttgcgtcg 321421 aagtattaaa atacctgcag aaatgttgta caatgaatgt cattcaggca aaaatggcta 321481 caacaaagcg cactataagc ttgaccggta aagccggtat ctatataaat attcgctaaa 321541 taagcatata atgaatatat aatttcattc cttaggagga tttcgccgaa gatgaacgct 321601 aaacgagcca tcccagtaag agaaagaaat atcgtcctga tcggattcat gggtgtagga 321661 aaaacaacaa tcggccaatt ggtcgctaaa aaattatata gagattttat tgatattgac 321721 cagcagatcg aaaaggattt caatatgtca attcctgaga tatttgagaa aaagggagaa 321781 gactttttcc ggaaaacgga gaaggaatat attttagaca tctgccatca taaacgattc 321841 aaaatcgtat ctctgggcgg gggatctttt aaacaagaag aaatcagaaa ttgctgtctg 321901 gaaaactgtc tcgtgcttca tctggacctg tcatgggaga actggaagca gcgcgcggat 321961 ttattgatcg aaagccgccc tgtactgcat aaccgttcaa tggatgaaat ggaacagctg 322021 tttaacgaaa gaaaagtcat ttatgacaag cacaattcaa aagtggcaac agacaacctt 322081 tccccggaag aggttgccga ttacattgtt gagacattaa aaattggctg ggatctttat 322141 cagccgatgt aaaaagccgt gcgcagcgca cggctttttt tatcgtttta tcccttgtat 322201 caaaatcgct tttaaacaaa aggagatggg ctgtccgttt tggttcaatg taatacagaa 322261 cgtgtcgcgt gcttcgtctg atgcgtgatt caagtgggta atgatttgtt tttctcggtc 322321 agcgggggtt ccgcctcgtt tgatccagct atcgtattga atcggcaagt tccacttttg 322381 gatgtcttga taggccagtt gattggcgct gaacatcgcc tgccattctg ataatgagct 322441 ttcacgaaca tgggaagggt ctcgaagccg gttcaaatga ttgacaaact catcaagaac 322501 gggatcttca ggcgcgtaat gatcaactaa gagaaaacgt ccgtcctgtt ttagtacgcg 322561 tgcaacctct ctgacagctt tgcggacatc tgaaaaatgg tgggctgcgt atcggcaggt 322621 gatgatgtca aatgaatcgt cggggaaggg gagtgactct gccgttcctt gctgaaagcg 322681 tacgttttca actccttttt cttgcgcgaa ggaggacgca acctcaacca tctctttcgt 322741 tgcatcaaca ccgatgcact cctgtacata aggagaaaat gccagcgccg tatggccggc 322801 gcccgctcct atatccagca ctcgatgctc tgcccggcat tccgctgttt tgatcatcaa 322861 ccccaaatct tccccctcgg caaatacctt ttcatcccga tacatctcgg cgtttttaga 322921 aaacggtgtt tcatttgtca tttgaaccag ctccttcttt tcgtaaatga tgatatggat 322981 tatgttagca atttctgtta tgattcgtcc aagatataaa aatgatgaaa atgataggtt 323041 caacctatgg aggctgaaat ggatattaaa gtgatggaat atgcagcgga aattgcccgg 323101 cgccaaagct ttacaaaggc ggcggaacat cttcatatcg cacagccgtc tctcagccag 323161 caaatcaaaa agcttgaggc tgagctgggg cttacccttt ttcacagatc ccatggctct 323221 gttacactga cacctcacgg caggcgtttc attgaaaaag ccgaggacat cattcgttcc 323281 agagatgatt tgcttcggga aatgcaggag cgatcacagg gaatcggtca taaattatcc 323341 atcgggattc ctgctgtaac agggagatat ctctttcctc cgctgctgaa gcagtttttg 323401 gcgcgctatc ctcatgtgga ggttcagctt gttgaaaaag atccggtttc attagagaag 323461 atgacggcaa agggagaagt tgacctttct gttttatcct tgcccatcga ggatgaacgg 323521 ctctccatta cacccttgct cacggaaccg gttgttctcg cggtgccgaa ggaaaaacaa 323581 aggtggatgc cgccggaatt ggtcgcgctg attgagaaag cgctggaaga agatgaggga 323641 cgccagccgt gtgtgccgat tgacatggta aggaacgtgc cctttattct gttaaaagaa 323701 ggcttcggct ttcgcaggac agttctcgat ctctgtgcgg aaagcggctt taagccgaat 323761 gctgccttta agacgagcca tattgaaacc gcccaatctc ttgtggctaa cggattaggt 323821 gtgacaatgg caccgaatat ggtcagaagg gataaagatc cgggtgtgat ctatttatcg 323881 attcaatccg cgccatcacg aaccctcgtc tttgtctttt taaagaaccg ctatgtcagt 323941 ctgacggccc aggcctttat ggaactaagc cgggaaagtc ttaaacaaac gtttgatgaa 324001 ggctgtctgg gaaacaaaga tgaaaatatt tagaaaacaa agacgaaacg tggtagtata 324061 ggaatacaaa ctaaatctta taaaacaaag gggaataatc ggaaatgcaa ctattcgatc 324121 tgccgctcga ccaattgcaa acatataagc ctgaaaaaac agcaccgaaa gatttttctg 324181 agttttggaa attgtctttg gaggaacttg caaaagtcca agcagaacct gatttacagc 324241 cggttgacta tcctgctgac ggagtaaaag tgtaccgtct cacatataaa agcttcggaa 324301 acgcccgcat taccggatgg tacgcggtgc ctgacaagga aggcccgcat ccggcgatcg 324361 tgaaatatca tggctacaat gcaagctatg atggtgagat tcatgaaatg gtaaactggg 324421 cactccatgg ctacgccaca ttcggcatgc ttgtccgcgg ccagcagagc agcgaggata 324481 cgagtatttc accgcacggt cacgctttgg gctggatgac gaaaggaatt cttgataaag 324541 atacatacta ttaccgcggt gtttatttgg acgccgtccg cgcgcttgag gtcatcagca 324601 gcttcgacga ggttgacgaa acaaggatcg gtgtgacagg aggaagccaa ggcggaggtt 324661 taaccattgc cgcagcagcg ctgtcagaca ttccaaaagc cgcggttgcc gattatcctt 324721 atttaagcaa cttcgaacgg gccattgatg tggcgcttga acagccgtac cttgaaatca 324781 attccttctt cagaagaaat ggcagcccgg aaacagaagt gcaggcgatg aagacacttt 324841 catatttcga tattatgaat ctcgctgacc gagtgaaggt gcctgtcctg atgtcaatcg 324901 gcctgattga caaggtcacg ccgccgtcca ccgtgtttgc cgcctacaat catttggaaa 324961 caaagaaaga gctgaaggtg taccgctact tcggacatga gtatatccct gcttttcaaa 325021 ctgaaaaact tgctttcttt aagcagcatc ttaaaggctg ataaatgtga aaagccgccg 325081 catatcatca ggcggttttt ttctgcaaac tgccggaatg agaacagact ggagacgaat 325141 agatatgaaa caaagaatca ttgatgaatt aaaacggatc gagcagtcat acggagtcaa 325201 aatcgtgtat gccgtcgagt caggaagccg cgcatgggga tttccctcgc aggatagtga 325261 ttacgacgtc cgctttattt atgttccgaa aaaggagtgg tacttttcaa ttgagcagga 325321 gcgtgatgtc attgaggaac cgattcacga tttgctggat atcagcggct gggagctgag 325381 aaaaacgctt cggcttttca aaaagtcaaa ccctccgcta ctcgaatggc tgtcctcaga 325441 cattgtgtat tatgaagcat ttacgaccgc agagcagtta agaaaactcc gcacggaggc 325501 atttaagcct gaagcaagcg tgtatcacta tatcaatatg gcgagaagga acgtcaagga 325561 ttatctacaa ggacaagagg tcaaaattaa aaagtacttc tacgttcttc ggcctatttt 325621 ggcctgccaa tggattgaaa agcacggaac cataccgcca atggacttta ctgttttgat 325681 gaatgaactt gttgctgaac ccgagctgaa ggctgaaatg gaaaccttgc ttgaacggaa 325741 aagaagaggg gaagagcttg acctcgaagc aagaatcgat gttattcacc aattcattga 325801 aacggaaatc gaaagaatca tggaagcggc aaaagaactg aaggcagaga aaaaagatat 325861 gacatctgaa ttgaaccgtt tgcttttgaa tacggttgaa gaagtgtgga aggatggagg 325921 aagctgatgt tttttgtcgc ttccttttct cctttattcg acagaatccc cccccgactt 325981 tctaactatc tgattgtggc aaacccacaa aaataatcag aatctttgta ttttgagaat 326041 attgtgaacg ctggttttgt ccatttacaa taaactcata caaatacttc ttagattgcg 326101 gggtgttgag gttggaagtg atcacaagag attttttctt atttttatcc aaaagcggct 326161 ttctcaataa aatggcgagg aactggggaa gtcgggtagc agcgggtaaa attatcggcg 326221 ggaatgactt taacagttca atcccgacca ttcgacagct taacagccaa ggcttgtcag 326281 ttactgtcga tcatttaggc gagtttgtga acagcgccga ggtcgcacgg gagcgtacgg 326341 aagagtgcat tcaaaccatt gcgaccatcg cggatcagga gctgaactca cacgtttctt 326401 taaaaatgac gtctttaggt ttggatatag atatggattt ggtgtatgaa aatatgacaa 326461 aaatccttca gacggccgag aaacataaaa tcatggtcac cattgacatg gaggacgaag 326521 tcagatgcca gaaaacgctt gatattttca aagatttcag aaagaaatac gagcatgtga 326581 gcacagtgct gcaagcctat ctgtaccgga cggaaaaaga cattgacgat ttggattctt 326641 taaacccgtt ccttcgcctt gtaaaaggag cttataaaga atcagaaaaa gtagctttcc 326701 cggagaaaag cgatgtcgat gaaaattaca aaaaaatcat ccgaaagcag ctcttaaacg 326761 gtcactatac agcgattgcc acacatgacg acaaaatgat cgactttaca aagcagcttg 326821 ccaaggaaca tggcattgcc aatgacaagt ttgaatttca gatgctgtac ggcatgcggt 326881 cgcaaaccca gctcagcctc gtaaaagaag gttataacat gagagtctac ctgccatacg 326941 gcgaggattg gtacggctac tttatgagac gccttgcaga acgtccgtca aacattgcat 327001 ttgctttcaa aggaatgaca aagaagtaaa aaaggagaga ttatcatgac aacaccttac 327061 aaacacgagc cattcacaaa tttccaagat caaaacaacg tggaagcgtt taaaaaagcg 327121 cttgcgacag taagcgaata tttaggaaaa gactatccgc ttgtcattaa cggcgagaga 327181 gtggaaacgg aagcgaaaat cgtttcaatc aacccagctg ataaagaaga agtcgtcggc 327241 cgagtgtcaa aagcgtctca agagcacgct gagcaagcga ttcaagcggc tgcaaaagca 327301 tttgaagagt ggagatacac gtctcctgaa gagagagcgg ctgtcctgtt ccgcgctgct 327361 gccaaagtcc gcagaagaaa acatgaattc tcagctttgc ttgtgaaaga agcaggaaag 327421 ccttggaacg aggcggatgc cgatacggct gaagcgattg acttcatgga gtattatgca 327481 cgccaaatga tcgaactggc aaaaggcaaa ccggtcaaca gccgtgaagg cgagaaaaac 327541 caatatgtat acacgccgac tggagtgaca gtcgttatcc cgccttggaa cttcttgttt 327601 gcgatcatgg caggcacaac agtggcgccg atcgttactg gaaacacagt ggttctgaaa 327661 cctgcgagtg ctacacctgt tattgcagca aaatttgttg aggtgcttga agagtccgga 327721 ttgccaaaag gcgtagtcaa ctttgttccg ggaagcggag cggaagtagg cgactatctt 327781 gttgaccatc cgaaaacaag ccttatcaca tttacgggat caagagaagt tggtacgaga 327841 attttcgaac gcgcggcgaa ggttcagccg ggccagcagc atttaaagcg tgtcatcgct 327901 gaaatgggcg gtaaagatac ggttgttgtt gatgaggatg cggacattga attagcggct 327961 caatcgatct ttacttcagc attcggcttt gcgggacaaa aatgctctgc aggttcacgt 328021 gcagtagttc atgaaaaagt gtatgatcaa gtattagagc gtgtcattga aattacggaa 328081 tcaaaagtaa cagctaaacc tgacagtgca gatgtttata tgggacctgt cattgaccaa 328141 ggttcttatg ataaaattat gagctatatt gagatcggaa aacaggaagg gcgtttagta 328201 agcggcggta ctggtgatga ttcgaaagga tacttcatca aaccgacgat cttcgctgac 328261 cttgatccga aagcaagact catgcaggaa gaaattttcg gacctgtcgt tgcattttgt 328321 aaagtgtcag actttgatga agctttagaa gtggcaaaca atactgaata tggtttgaca 328381 ggcgcggtta tcacaaacaa ccgcaagcac atcgagcgtg cgaaacagga attccatgtc 328441 ggaaacctat acttcaaccg caactgtaca ggtgctatcg tcggctacca tccgtttggc 328501 ggcttcaaaa tgtcgggaac ggattcaaaa gcaggcgggc cggattactt ggctctgcat 328561 atgcaagcaa aaacaatcag tgaaatgttc taagcgggac taaatgggca tcctccctgc 328621 gggggtgtcc atttcatcca tatactataa aaaagaggag gaagtgccat agaaaacaca 328681 cagctgatta tttcgatttg tatttatatg gcgggaatgc tgctaatcgg ctactttgct 328741 tacaagcgta cgtcgaatct gacggattat atgctgggag gacgctcttt gggtccggca 328801 gtaaccgctc tcagtgccgg cgctgccgat atgagcggct ggctgctaat ggggcttccg 328861 ggcgccatgt tttctactgg tctgagcggc gcttggatcg tcatcggact ttgccttgga 328921 gcgtgggcga actggcttta cgtcgcacca cggctgagaa cctatactga aaaagcgggg 328981 aattctatta caattcccgg attcctggaa aatcgcttcg gagatcaaac aaagcttctc 329041 agactgtttt cgggaattgt cattttagtc tttttcacgt tttatgtatc gtccggaatg 329101 gtgtccggcg gcgtcttatt caacagcatc ttggggatgg attatcacac cggcctgtgg 329161 attgtgacgg gtgttgttgt ggcatatacc ctgtttggcg gctttttggc agtcagctgg 329221 acagattttg ttcaggggat tattatgttt gccgcactca ttcttgtgcc gatcgttacg 329281 tttttccaca cgggaggagc aggtgataca gttgctgaaa tccgctctgt agatcctgat 329341 atgtttaata ttttcaaagg aacgagcgtc cttggcatta tttctttgtt tgcctggggg 329401 ctgggatact ttggccagcc gcatattatt gtgcgtttta tggcgataac gtctgtcaaa 329461 gagatcaaaa gagcgcgcag aattgggatg ggctggatga ttttgtctgc agtaggcgca 329521 gtgctgaccg gtttgggcgg aatcgcttat taccatcagc gcggcatgac actgaaggac 329581 ccagagacga tttttattca attagggaat atcttgttcc atccgattat cacgggtttt 329641 ctgatttcag cgattttggc cgcgattatg agtacaattt cttcccagct gcttgtgaca 329701 tcaagctctc tggtagaaga tttgtataag tcgatgttca gacgctcagc ttcagataaa 329761 gaactggtgt ttttaggccg actggctgtt ctggctgttt caattgtcgc gttggttctg 329821 gcttgggaga aaaataacac catccttgga ttggtcagct acgcgtgggc gggcttcggt 329881 gcatcattcg ggccagttgt actgctcagt ctgttttgga aacgaatgac caaatggggg 329941 gcactcgccg gcatgattgt gggagcagcg actgtaatca tttgggcgaa tgccggtctt 330001 tcggactttc tgtatgaaat gatacctggt tttgctgcga gtctattatc tgtctttttt 330061 gtcagcatat tgacgcaggc tccgtcacaa gctgtcacag accagttcaa cgactaccaa 330121 gatacaatgt cgcaataaag atcgaaagga ggaggaaggg gctgtccctt tttcctcttt 330181 tctcctttta agcggccatt tttttctttt ggaaacaaac gtattttttt ctatacaaaa 330241 agaccccgta tggatatgat taaagtaaaa aaagtatagg agaaaaaggt atggaagagc 330301 ttttagagag agttttttca ttttcagatg ttgataagct aattgatttt attagctatg 330361 aactgcaaaa gccagtgata ctggaaagcg cggatttctt tttgttagcc tataattctt 330421 actatattaa ccattttgat tctgccaacc agcagactat tttttcgaaa aagtgtccgg 330481 tccagatttt tgagaggttt ctgaaggacg gaattattga aaaattgaaa acagagcctg 330541 agccttttcg cgtcaataaa attgaaagca ttgggttaaa ccagagggtg gtcgtgagtg 330601 caaagcacaa aggggaagtc atgggctaca tctggattca ggagctggac caaaatctga 330661 cggatgaaga gctcgacttt ttgtacgaga cctccttcca tgtcgggaaa atcatttata 330721 aaacgaataa attgaaacag gaaaaggaag aaaaagcaga ggatctcatc aaacgggcga 330781 tctatcagca atttacctct gagaaggaac tcagacggga agctgaaagg atcaacaccg 330841 tgctgccttc catgttttca gttgttatcc tgcacgccgc aaatggggat ggggaagcgg 330901 ttgaggattt aaaggaaaat atcaggtcgt acctgaattt acgggataag gtcagtcatg 330961 tcttaacgat cgaatcaaac attgtcatcg tcgtagcgag tttttcccaa aaaagctccg 331021 tctcctcagc agcttctgag tttattaaca agctgttaac acattttcac tttcaaaaaa 331081 tacctacccc tatttatatc ggtatcggaa acgaatataa tcacctatta aaacttggca 331141 agagctacac agaagcactt gaagtcatca aagccgcaga aatcaccggc aatcaggaaa 331201 acattccata tgaatatgcc aaactcggca tttaccgcta tttagaaagc atcgaacaga 331261 aaaatgaatt tttagaatac gagaataaag atttagcttt attaaaagca aaagacgaag 331321 aaagcagcac tgagctgctc aaaaccttgg aaatctatct cctcaacaac tgcaaaacaa 331381 aaccagcggc agaacagctg tttattcacc aaaatacatt gaattaccgc atcaaacaga 331441 ttactgagat gacgtcgatc gatttaagcg atttcagaac gcggtgccag ctctatctcg 331501 atttgatgct gatgaaaaag aaataaaaaa gaaaccagta cttgtactgg tttcgtcttc 331561 acttaaaatc ctctgtaaac atacggatca tcaggttttt taatggtatt ccagtcagtt 331621 actttgacga cagggagagt tgacttgaat ggctggtaat attctgaggc cagagtgccc 331681 ttaatgtgaa tccattcatc atccttgatg tccatgtcct tcggaaattc cacaagcatc 331741 ccgtacacgc cggaatcagc gatacagtga atgatgccaa accttaatac gaacagctga 331801 tttttgttaa ttgcgtttcc tttgtaagca aatccatgaa attctatcgt ccgtccgaga 331861 aattcacccg gatagttata gatggtttcc attcctttta ggaaatcgtc atcggtcaga 331921 gaaatctctt ttttgctgga atacttatta aacagctgtt tcatttgttt gtcatagctg 331981 tcttgcgcgt aataaaggct ggcatcaggc cgcaaatact gtgtttggga gtagtgatct 332041 ccgctctcca tcgccttaaa cgagaaccct tttgttttga ctatggatga gtcaagcgtt 332101 gcaatcggga agaagatgcc tgacaccaaa ggaaaaagaa aaacaacata aatcaaataa 332161 cgctgataaa atggcttgtt ttgttcatgg tcatgctcgt gatcatggcc gcacccgcaa 332221 tcatggtcat ggtgatgtcc gcttttttca ggcgacttga taaatagata tgcttggacg 332281 gcggtcagaa tggccagcag gaagatcgca ataaaggaaa gataggcata tttcatattg 332341 atatattttg ttagatttcc tgaggcatgc agatgataaa agaaaaacgt aaatcccatc 332401 agcaccaata aacgaaacat ccaatcaccc ctttaccagt agtgatcccg ctaaaacaat 332461 cacgacaatg tatgtaatca gcaggaaaac aaatcgtttt ttgaaggccg caagcatcat 332521 caatagattc ttaatatcca ccattgcacc aaagacgaga aaggcgatta acgatcctaa 332581 tgaaaacgtg ctgctgaagg aagacgcgat gaacgcatca acttctgaac aaagcgacag 332641 gacaaacgcc agacccatca tcacgaggga agaggataca tcattctgcc cgatcgcaag 332701 cagagtggat gttttgacat acgtctgcat agcggctgcg ataaaggcgc cgatgattaa 332761 atatttcccc acggagaaaa attcatcaat ggcatgccgc aaggtcccgc ccagtttttg 332821 gagcaaggtg ccgtgatgat gatggtggtg cccgggttca tcaggcttta aaagctggtt 332881 atccttaaat tgataggata agatgacccc gatgatcagc gaaacggcga gagccagtcc 332941 gcctctgtaa aagaccacgc tccatctatt cccgaacgca atataagtag aaaataaaac 333001 gataggatta atgataggcg cggtcagcat gaaagcaacg cccgcatgca gaggaactcc 333061 ctttaacaga agccgcctcg taatcgggat gatgccgcat tcgcaggcgg gaaataaaac 333121 gccggccagc gcaccgaata aaacggcgag aaaacggttt ttcggcatga ttcttgcaat 333181 catttcttca gaaacaaaca tttgaatgat tccggaaagt atgacgccaa tcagaataaa 333241 cggaatggct tctattaaaa tgctgataaa aatagaattc agctgaagaa aagatgattg 333301 tgctgtcaca ataaaacctc cgctcatgtt aagctgcctt tcttatgata ccagaaaaaa 333361 aggcactgct tgtttgacgg aggaggggaa aggatcgttt cactttggtt aggattccaa 333421 aaagccgagt aggatactgc ctgtttctgc agcttctttt ccgagccaaa tcaggtgtcc 333481 ccatgagtga agcaaacaga gaacagcgcc acgaatgtgc tcttttgcat gatgtgcatg 333541 tgacaagtca accaatccgt cataaacact ttgcataatc agcacgggac atatgatggc 333601 ttgcaggtct tttaaagaga cagcggcggt ttgtgacaag tcaatcagaa atccttcacc 333661 cgagcgctgc cggctgttca ttttccgaaa tgcttctatg tctttttcat tcatcaagga 333721 cttgattcgc tgaaacggaa gcgtgctgaa ttgggggctc atagctcgaa acatcaaacg 333781 cgggaaagcg ttattcaagg aagaaatcag cttccatatc cacttttcca ccggcgggcg 333841 gaagagaatt tcccccaatt tatattcagt gtcttttggg gtgagccact ctttggtgac 333901 tgcggattgc agggtcaatg tatttactct ttccggataa tgtgaggcaa agcatatgcc 333961 gctcggccct cctgctgaga tggcgatcac atggacactc tcgatttgta gatgatctaa 334021 taatttcaca tagaaacggc aggcattggc aagacttttt ccaatttctt ttgacgtccg 334081 tccatagcca ggccttgaag gcgtaatgat ggaataccct tgttcaatca acgctgtgta 334141 tccgaattcc tcgtaacaat ttgaatgccc gccatgcatg acaaggatcg gagttccctt 334201 gcctgtcaca gaatattcta gtgtaccgcc atcgaaggtg atcgtttcaa ctcgtctttt 334261 catctgtttc acccaattgg tttttgccta ttatagagtt ttcagcaatt gaccacaagg 334321 tagaagaaat gaataaacaa aggcccttga aatatgatat actttgtatt gatattcatt 334381 ctcaattaaa actttgatat agatgtgaac gggaggcagg acggatggct gagaatcaag 334441 aggtatatga cgttacgatt ataggcgggg ggccgatcgg gctgtttact gctttttact 334501 gcgggatgcg ggagctgaaa acaaaggtaa tcgaattttt gccgaagctc ggagggaagg 334561 tgtctttatt ctttcctgag aaaatcattc gcgatatcgg cggcataccg gggattgcgg 334621 gaaagcagct gatcgagcag ctgaaggagc aggcggcaac gtttgatcct gatatcgtat 334681 tgaatcagcg tgtgaccggg tttgaacgcc tagatgacgg caccattgtt ctgacgggtt 334741 ctgaagggaa aaagcactat acaagaactg tgattttggc ttgcggcatg ggtacacttg 334801 aggtcaatga gtttgacagc gaggatgcgg cccgatatgc gggcaaaaat cttcattatg 334861 gagtggagaa gctcgatgcg tttaaaggga aacgcgtggt gatatcaggc ggcggagata 334921 ctgcggtcga ttgggctaat gagcttgaac cgattgcggc gtctgtgact gtcgttcatc 334981 ggcgtgagga attcggcgga atggaaagca gcgtgacgaa aatgaagcaa tcatcggtgc 335041 gggtgcttac gccttatcgg ctggagcagt tgaacggaga tgaagagggc atcaaaagcg 335101 tgaccgtttg tcatactgag tctggccaga ggaaagacat agaaattgat gagctgatca 335161 ttaatcatgg gttcaaaatt gatctcgggc cgatgatgga gtgggggctg gagattgaag 335221 aaggaagggt gaaagctgac agacatatgc gaacgaatct tccgggcgtg tttgtggcgg 335281 gcgacgcggc tttttatgaa agcaagctga gattgattgc cggcggattt acggaaggcc 335341 cgacagcggt caacagtgcc aaggcttatc tggaccctaa ggccgagaat atggcgatgt 335401 attccaccca tcataaaaaa ttggtgcata aataaaacag cccttgagga aaagggctgc 335461 ttgccatcag gtgtgaagga gttttttctc tgcatgttga ttgtggatga aagctagcaa 335521 ttcatcctgt tcttgtacgg ctgtgaatcc ataaatgccg gcagctgagt catcgcctat 335581 gcagacgata ggagggcggc ttgctgacgg ttccggcaaa atgccaattt gttcgccacc 335641 attgatcaat tgctgaacgg acagcttgtt tgggcaaatg accatgtgca gcggggattc 335701 actgatggta cgctgaatca tgtgggtgaa ccggtcatct atgacgtttt catgagtgat 335761 ataaaacgaa caggattcat gcttttgcat gttttccact gcatggcggc tcccgacaac 335821 aagacgtttc tctgaatcag gctgaatggc ggtgacaaga aagccccgtt tctcaagctc 335881 tgtctttgct tgctcagatg ctgcactcag tttggctgtc agctggcgga tgtcgatttt 335941 ctgagaagcc agtgctctga aaaattcaca aaccgcccgg cgcgatgtga aaaaaacgtc 336001 ttcaaaggtg ccaatctttc gaagaatttc ttcattgaca ggcatgtttt cggtccgcca 336061 tttcggccac tcgatgagat cggcgccgga atcgcgcagc ttgtctgcaa gcgggtcttc 336121 atcttcgcca tgagtcacaa ccatcaaatg ccgtccgatg agcggtttgc tttcaaacca 336181 gctgtgtgtt tgaaagttga cgatgtctcc gatgacgata atcgcagggt ttgtaatctg 336241 gtgttcctgc actttttgct gaatgttctc aagtgttcct ttcacactcc gctggcggcc 336301 ccacgttccc cattggatga caatgacagg gacagaaggc gatttcccgt atgaaataag 336361 ctgctggcaa atataagaca agttcttgac acccatgtaa aaaacaaggg tttgaacgct 336421 tcgggccagc ccttcccagt caaggttcgg cgtgcctttt aatgatttat catgcgctgt 336481 aatcatggca aaagacgatg caaaatcccg atgcgtgacg gggatgcccg catatagcgg 336541 cgctgcaatt ccagaggtga ttcccggcac catttcatag cgaatgccgt gctcatgaag 336601 agcatctgct tcctcgccga ctctgccgaa tacgctcgga tctccgccct tcaagcgaac 336661 gacggttaac ccatttaatg ctttttcaac cagcagggcg ttaatttctt tttgtttcat 336721 aaaatggcgg tttggcagtt ttccgcaata aataaactgg cagtccggtg atgcaaattc 336781 gagcagcttc gggttggcga gccggtcata taaaatcaca tctgcttcct tgagcgcctg 336841 ttttcctttg atggtgagca ggcctgggtc gccgggtccg gctcccacga aatatacgat 336901 tccgttcttc atgatcatgt catccttccg tcactgtaaa aaatgaagga ccactagaaa 336961 agtgatccgg tcttttgatc aatatacgag ataaacatgt tctccttcga tcagcgtttc 337021 atatgttttg acgcatccgt ggtcaggttc ttggacgatt ccgtcttcta aggaaatttt 337081 ccagtcgtgc atcgggcaga aaacatattg accgctgacg atgccttctg ccaggacgcc 337141 gcccttatgc ggacagcggt tttcaatggc gcggatgctt ccgtctgaaa gcttgaaaac 337201 cgcgagctcc ttatcttcaa tatacactgt tttgcctaat tgttcaggca attcttcaat 337261 ttttccgata catacttttg ttacgtcttt gtttaccatg tccattcctc ctcaatgata 337321 gtttttgtca ttatgatgtg gtcacgacat tttcaaataa ttctttagag gtttgtttat 337381 cctctaaaaa gtctttccac ggatccttgt ggacagagag tgtttcattc attcggccgt 337441 tcagctcctg ccgcttttcc ggatcgttta acacggattg gacatgggat aaaccgacgc 337501 gctcaagcca tgcggacgta cgctccagat agtttgcggt ttccctgtaa tattgcaggt 337561 aagcgcccgc gtattctaag acttcttcat ttgttttcac cttcatcagc aaatcgccgg 337621 cacgcaaatg ggttccgccg tttccgccga cataaagctc ccagcctccg tcgatgccga 337681 caacgccaag gtccttaatg ccggattccg cacagtttcg cgggcaggca gacacggcca 337741 ttttgacttt gtgaggcgtg ttcagccctt cgaatttttt ctcaagcgca atgcccagtg 337801 ccatggagtc ttgtgtgccg aagcggcaga attgctcgcc tacacatgtt ttcactgtgc 337861 ggagcgtttt tccgtacgcg tagcccgatg gcatatcaag atcttcccat accttcggaa 337921 ggtcttcttt tttcacgccg ataagatcaa ttcgctggcc gcctgtcatt ttcacgagcg 337981 ggatctcata tttgtcaacg acatcggcga tcttgcgcaa atctgtggag ttggtcacgc 338041 cgccgtacat ccgaggaacg actgagtatg ttccgtcttt ttgaatattg gcgtgcattc 338101 gttcattaac aaagcgggat gtccggtcat cctcgtattt ggttggattg atcatgccta 338161 agtagtagtt cagagcgggt cggcatttag aacagccttc tggcgttttc cagccgagca 338221 cattcatgac ttctcttgta tgtgacagcc ctttggcttt gatttcttct acgacttcat 338281 ctctcgacaa tgtggtgcag ccgcaaatgg cttctttttg cgctgacgca tcaaagtctg 338341 atccgagcgt atgctggagg atttcttcta cgagcggctt acagcctccg catgagcggg 338401 atgcgccggt gcatgctttg atttcgtccg ttgacgagca gcccttttcc tgtatggctt 338461 gaataatcgc accttttgac acgccgttac agccgcagat gatttcatcg tcgctcatcg 338521 ctgcggttat gcttgtgcct gcttcctggc tgaggggctg taagattgat attttagagg 338581 tttcagagat atcggcttct ttttgaatca tagaaaacag gcgattgcct tcgctgctgt 338641 cgccgaataa aacagcaccg acaatttgat tgcctctcag gacaattttt ttatagatgc 338701 cgtcctgctc atcgaagact ttaatcgctt ttttctcctc tgattcgtta aagtcaccgg 338761 cagagaagac ctcgacgcct gataccttta actgtgtgga gagaacggag ccctcatacg 338821 gttttgtttc gatgccgcac atatgctttg ccagcacttt tgcctgttca tacagcggcg 338881 ccacaagccc gtaggcgatt cctcggtgct cggcacattc gccgaccgcg taaatgtgcg 338941 ggatttcagt ctgcatataa tcgttgacga tgatgccgcg gttaaccgga atgccgctct 339001 cggccccgag cgttgtattt gggcggatgc cgacagccat gacgactaaa tcagcttcaa 339061 tgcttgtgcc atccttgaat cggaggcctt cgacacggtc gtcaccgaca atttcttctg 339121 tttgcttttc aagtaaaaag gtcatacctt gtttttctaa ctcgttttgc agcaggcgtc 339181 ctgccgttgc atcaagctgg cgctccatca ggaatggggc aaggtggatg acggacacgt 339241 ccatgccgag attcagcagt ccgcgagctg cttccaaacc aagtagtcct ccgccgatga 339301 cggcagcttt tttatattgt tttgacgcgg cgagcattgt gtctgtatct tttatgtccc 339361 ggaaagctgt gacgcctttt ttgtctgcgc ccggaatcgg aaggataaaa gggaccgatc 339421 ctgtcgccag gatcaattca tcgtaaggct ggattctgtc tgcatctgtg atgactgttt 339481 tgttttccgt gtccactttg atgactgttt catttgtata caattgaatg ttgttttctt 339541 cgtaccagtc ccaatcgttt aacgtaatat ctttaatatc tgtatcgcct tgaagcactt 339601 ttgacaaaag gattcggttg taattgggat gcggttcggc accgaaaatt gtgatctgaa 339661 actcgtcttt agcaacactc agtatctctt caatggccct taccccggcc attccattac 339721 caacaagaac tagctgtttt tttcccatca gatgatccgc tccttatcaa atgttttttc 339781 cagcgtagca cagcaaaaag gaatatttaa gatacatgtt ataaaatgta acaaaatata 339841 cgaaaagttc taaaaatttt atgaaaaatt taaataggta tgattcggac ggcgcatacc 339901 ttaaaaccgg gcattttaca ggctggatct aaggcttccc cgattaaatc attcacattt 339961 tgagcgtctg cccaatggat gggaacaaaa acggtatctt ttctgatttg ttctgataat 340021 ttgctgcgga cggtgatgct tccccgcggc gattctattt ttaccagtac acggtcctcg 340081 atattgtagg tcgctgctgt ttgcggatgg atctccataa acgattcaaa atgtctcgcg 340141 gcaagggcgg cgctttttct tgtttggacg cctgttaagt agtgagacat gactctgcct 340201 gtcgttaaat aaagcggata atcggctgtc ggcttctctt ttggaacagg tggttcgttt 340261 ggaatcacac ttaatgccgc tttttgatcc ggatgagcaa atgattctgt aaacaagcgc 340321 ccagttccgg gatgatcaga ttccggacac ggccaatgaa tgccgccttc acgtctgagc 340381 ctgccgtatg agatgcctga ataatcggca atcccgcctc ggctcgcttc tctcaattca 340441 ttgaaaatat cctccgctga cgtataagaa aagtagcggc ccttgccgag agcggatgcg 340501 agatcacaaa tgatctgcca atcatgcttt gcttcgccgg ggcatggccg gcttgcttct 340561 cttaatgtca cgcgtccttc tacatttgtc atggtgcctt catcttctaa gtaagaggag 340621 gcaggtaaaa tcacatctgc gtatttcgca gtctcagaaa taaacaaatc gattgcgaca 340681 aagaatgtca gtcttcttaa agcctttttc acgagatttg catttggact ggaaacagca 340741 gggttggagc acatgaggaa cagtcctttg atgtcgccgt cattgatttt ttccatcatt 340801 tcataggctg agacaccttt tcgcgggagt tcatcctgat ggattcccca cactttcgca 340861 atatgcgccc ggtgttcttc gttttcgata gaacggtagc ctggaagctg atcggctttt 340921 tggccatgct ctctggcgcc ttgcccgttg ccttgtccgg tgatcgcccc gtagcccgag 340981 taaggtttgc cgatttttcc tgtgatcagc accatgttta agaagccttt cacagccgct 341041 gttccatcgg tttgctgttc aatcccgcgg gctgtaaaca gcatgccgga cgtttccttg 341101 gcaaacttca cagcagcttt tcttatatcc accagcgaga cactcgtctg ttcggcgatg 341161 tcattcaggt ccaacgagtc agtatgctgc ttcagctctt cgaatccatt tgttcgtgat 341221 tgaatgaaat cctcgtttat aagctgttcg tcaatgatga ttttgacgag accgttggca 341281 agggcggcgt ctgtgccggg tttgattttc agatgaagat cggcgatttt cgttgtcgct 341341 gtttcacgag gatcaatggc aatgaagtaa gctccgtttt ctttcgcttt ttcaaaatac 341401 ggcataatcg taggctggca ttccgcaata ttggtgccgg ccagaatgat cacacgggtg 341461 tgggggatgt ctgataaagg attcgttaag cctctgtccg cgccgaatgt ttggttggct 341521 gcggtggctg ctgcggacat acaaagtctc ccgttgtagt cgatgtattt tgtctgtaag 341581 cctactcgtg cgaacttccc taacaaatac gcctcttcat ttgtaatcga ggcgcttccg 341641 tataccgcca tggcgtcatg tccgtgttca gtttggatca ttgtcacttg gtctttgata 341701 tgattcagtg cttcttccca ggaaacaggc ataaactcgc cgtttttctt cagcagcggc 341761 cgggtgatgc gggaggagtt caaggcatgc tggtgagcat tcatgccctt gatgcatagc 341821 cgaccctgtg tcgtaggatt atcaatcccg atcgcagtgt actttttgcg cgtgacgatg 341881 gtttgttcca cgagctgcat tttgcactgc atgctgcaaa acgggcattg agtgtcatat 341941 gttttttctg attggacgtc ttgctgttta tcacggaaat atctaagcag tcgttcagtc 342001 aaaatgcctc atcctttctt atatgcgccc gtctctacag tcgggttttg aatcagtgac 342061 agatctgttt ggaggctttc cagcagctgt gcccttaggt cttcttcgaa tagcacttct 342121 ctgatatgaa cgatcccgag acggtctatc cactgatgaa caccttctaa gtaatgagcc 342181 gtttcccgat aatactggat cagtcctttg atcatgccgg cagtgctgtc ttcgttctca 342241 gtcacgcaaa acaaagctcc tgaacgggca tgagttcccc ggacgccgcc gatgtgaatg 342301 tcccagccag cttgtgtccg aattgcgccg acatcttgca gggcggcctc ggtgcagtct 342361 gtttcacatg ataagctgat agaaatggga gcgggtaagg gaagcatctc aagttgtctt 342421 tcgatttggg ctgccagctg ctgaatcgat cgattttgcc cgcatgtaca tgctttgatg 342481 ctttgcagcg cgtgtcggtg ttcattagtg taaacgggca ttttcaggtc ttttttcatg 342541 ttcgggagat ccgcaggctt gatcccggaa agcttcagcc tttggccgtg agtgatggat 342601 acgtcgggaa tgctgtatgc ctcaatgatg ttggcgatgg ttcttagctg ctccgcgttt 342661 gtccgcccgc cgtacatttg cggaatcagg atgcatgtct cttcagtggc tggctcaggc 342721 tggacaaacc cagggtacag catttccaga tagtattgaa tcgcaggaac acaagtactg 342781 catccgtttt ttgttttcca gtcaagctgg ttcatcactt ctgccggatt agtgaatggc 342841 ctgcgctgaa gctcagcgat gatgtcgtct tctgtaaaat cagtacagct gcaaaacgaa 342901 ggtgtgctgg cgggcttcgt atattcgctg ttggtcatgt atctcaaaag gtcttcaacg 342961 agcggtttgc atcctccgca ggacccagtg gctttggtgc agtgcttgac ttcctcaaca 343021 gttgttaagc tattcgtgtg caccgcgtct tcaatcgcgc ctttcgtcac tgtgttgcat 343081 tggcaaatcg tttcactgga aggcatggat tcaaataaag ggccgcttgt ctccggttcg 343141 atgatctgtt ttttggcaat ggagatgtct cgttgtttaa gcaggctgtc gagaagccgc 343201 tgcttgtcac gggtgtctcc gaataaaata acgccggcca gtttgtcatc tacaaaaagc 343261 gcttttttat aaacgcctgc ttgttcgtcg tagattttga tgctcgtcgt gcgttcatcc 343321 tcttggatct ttcctgctga ccacacatcg attccagcta tttttaacgc cgcagatggt 343381 gctgagcctt gatattcctc acatggaacg ccgcaaatat gactggcgag cgcttttccc 343441 tgctcataaa gcggagccac caatccgtac accgttccgt tatgctcagc gcattcacca 343501 acggcgtaga tattcggttc gcttgtctgc atgaagtcat tcacgatgat cccgcggttc 343561 actttgattc cagcggatac agccaattca atattcggtt tgacgccggc cgccatcaca 343621 atcaagtctg cttttaatga agagccatct ttaaaatgga ttcggtctgc cttcgtggcg 343681 ccggaaatgg agacggtgtc tttctccaaa agaaaggtta ggcctttttg ttccagctct 343741 gtttgcagca gccgcgccgc tgtttgatcg agctgttttt gcataatgcc ggcggagtgg 343801 tgaatgacgc tgacatccat accgagatgc tgtaaaccta ctgcagcttc cagtcctaat 343861 aagccggctc cgattaccgc agccttttga aagtgctggg ccatgttcat cagcgcttgg 343921 cagtcttcta ttgtccgaaa tccatagaca ccttttttgt ctgccccggg gatagggaga 343981 atatgagggg aggagcctgt tgccactatt aatttgtcat acgacagagt gcgtttccga 344041 tctgtgatga cctgctgctg atctgtatca atctgaataa ccgtttcgcc tgtgtaaagc 344101 gtgatcccgt gcttgtcgta ccaatccttg ctgttcagtg taatatcatc gagtgacgct 344161 tcaccctgca atacagagga taagagaatg cgattgtaat tgggatgcgg ctcgcttccg 344221 aaaatgacaa tctcaaacat gtggcgattc agctttaata cttcttcaat acagcggatt 344281 ccggccatgc cgtttcccgc taacactaat ctttgtttct tcatgtatca gacctccttt 344341 ggcgaagctc gtaagttttc tcctattaaa aattatgtca caatgcattg ttaacgcatt 344401 aaacgtgtca caaaaactta cacatgtctt ttccagaaaa taatggtcct atatccttga 344461 ttcagaaaat gtaaaataat gagggtctag aaaggggaat cttatgaagc tgtcggaact 344521 gaaaactagc ggtcatccac tcactttgct ctgttccttt ttatactttg atgtcagttt 344581 tatgatatgg gttatgcttg gggcgctggg tgtttatatt tctcaggatt ttggcctgtc 344641 tccttttgag aaagggcttg tcgtagctgt gccgatttta tctggatctg tgtttcgtat 344701 cattcttggt attttaacgg acagaatcgg accgaaaaaa acggcagtga tcgggatgct 344761 ggtgacgatg attccgctgc tttgggggac attcggcggc cgttccctga ctgagctgta 344821 tgccatcggg attctgcttg gcgtggcggg agcaagcttt gctgtagcgc tgcctatggc 344881 cagccgctgg tatccgcctc atttgcaggg acttgcgatg gggattgccg gagcggggaa 344941 cagcggcacg ttgtttgcaa ccctgtttgg ccctcgtctg gcagagcagt tcggctggca 345001 cattgtcatg ggaattgcgc taattccatt attgatcgtc tttattcttt ttgtatccat 345061 ggcaaaggat tcccctgcac agccgtctcc ccagccgctc aaaagctatc tgcatgtgtt 345121 tgggcaaaag gaaacatggt ttttctgcct gctgtacagc gtcacatttg gcggatttgt 345181 cgggctctca agctttttat ctattttctt tgttgatcaa taccagctgt caaaaattca 345241 cgcaggggac ttcgttacat tatgtgtggc ggcggggagc tttttccggc ctgtcggggg 345301 cttgatttca gatcgtgtcg gcggcacgaa agttctttct gtattgtttg tcatcgtggc 345361 actgtgtatg gccggagtca gtagcctgcc atctctctca atggttattg ttctattgtt 345421 tgtcggaatg atggggctcg gaatgggaaa cggcgcagta ttccagctcg tgccgcagcg 345481 cttccgcaaa gaaatcggca tggtgacggg aatcgtcggt gcggccggag gaatcggagg 345541 gtttttcttg ccgaacatct taggatctct caaacagatg acaggcacat atgctatcgg 345601 ttttatcacg ttttcctgta tcgcgctgct ggcgtttgca cttgtgcttg ccgcaggcta 345661 ttactggcgg aaaagctgga gcgcggaaag cagcccggcg gatgtttagg attttgacgg 345721 acacgcgttt gtgcgtgtct tttttatttt ctcttgattt tcaacagtga accgatcaaa 345781 ataaatagta attattacga tttgttagtg agaggagttt tctgaatgaa tcaacatacg 345841 ctgctcccga aaaaaacgga gcgtcttcaa tactttggat cggtcagtcc gatcaaaggc 345901 gagaaaccag tggaaaaaga gaaaatgaag gacctgcaaa atatcaggaa ggattatttt 345961 tttgacattc agcatgtagg tgtagctaat gtgtcccatc cagtcacaat cacttctgcc 346021 atgatgcctg ccgagcaaac aacggctgcg aactttacaa tgacttgtaa tttgccgaga 346081 aatcagaagg ggattaacat gagccggtta acagagctgc tgcaagtcta tcatcaaaat 346141 ggctggattc tctcattttc ctctcttcag caatttacga aagagcttgc agaaaacatg 346201 gacacatcat ctgccacagt tgaagtgagg tttccgtggt ttttcgaacg gaaaagcccg 346261 aagcttgaga aagcgggttt gatgcatgct gatatattca tgtctgtcac ctatcgcaaa 346321 gatcagccgt ttaaacagcg tgccggcatc tcagcaaaag taacgactct gtgcccttgc 346381 tccaaggaaa tcagcgaata cagtgcccat aatcagaggg gaacggtcag catttgggcg 346441 gatattcacc cggccgcatc gctgccaagt gatgttaaag ctgatttgct tcacgccgca 346501 gaatcaaatg cttctgcgag actgcatccg gtattgaagc ggcctgatga aaaagccgtg 346561 acagaaacgg cctatgaaaa cccgagattt gttgaggatc tcgcccggct gattgctgca 346621 gatttgtttg agcttgaatg ggtgtcagcc tttgagattg aatgccgaaa tgaagaatcg 346681 atccatcttc acgatgccta tgcgaagctg tgtttttcga aggaagtgga taaaatatga 346741 aactctcatt attcattatt gcagttctta tgccagtcat cctgctgtca gcctgctccg 346801 atcatgcaga agaacacgca agtatcaata caaagaaaac ggtcgaaaac ataacggacg 346861 ttcgaaaaac agcaaaaaca agcattgatt ggacaaagcc ttcgggcgga gaatacccgg 346921 atattaaaca gaagcatgtc tggattgatg tgaatgtgaa ggagcagaag gcttacatca 346981 aggaaggaag caacaccatc tatacaatga tgatttcttc tggtcttgat caaacaaaag 347041 atgatgctac gccaaagggc accttttatg tagagcctga acggggagaa tggtttttct 347101 ccgaaggata ccaggaaggc gcagaatact gggtatcatg gaaaaatcac ggtgaatttt 347161 tatttcatag tgtgccaatg actaaggatc aaaaagtcat caaaacggaa gcagaaaaac 347221 taggaacgaa agcatctcac ggatgtatca ggctgaccat tccagatgcg aaatgggtat 347281 atgaaaatat ccctgaacat acaaaagtgg tgatcagctg aattgaaaac cgttgacaaa 347341 aaggaaaaaa gaccatacaa tttaaatcgt aacaattacg ttttatgata aatggcttat 347401 cattgtctgt gcatctgtga aaagcggaaa ggcatcgatt aaggatcttg ctgtcggcaa 347461 aggcaaggat ttgcgatggg gaaaaggatt aaacgcggtt ggagtcttta ctgatttaga 347521 aatcgggcgg cagcgagaaa tgagcgcgaa aagctgctct acaccattgt acatacggcg 347581 aagtattcaa tttaaatcgt aatcattcta ttttaatgga ggcactatta tgaaaaaaat 347641 tccggttacc gtactgagcg gttatctcgg tgcgggaaaa acaacattgc tgaacagcat 347701 tttgcaaaat cgcgaaggct tgaaaatagc ggttatcgta aacgatatga gcgaggtgaa 347761 cattgacgcg ggcttggtta agcaggaagg tggcctttcc agaacagatg aaaagcttgt 347821 ggaaatgtca aatggctgca tttgctgcac gcttcgcgaa gacttattaa ttgaagttga 347881 gaagctggca aaagacggac ggtttgatta tatcgtcatc gaatcgacag gaatcagcga 347941 accgatcccg gtggcccaga ctttctctta tatcgatgaa gagatgggaa tcgatcttac 348001 aaaattctgt cagctggata cgatggtgac ggttgttgat gccaaccgtt tttggcatga 348061 ttatcagtca ggcgaaagcc ttctggaccg caaagaagca ttgggggaaa aggatgaaag 348121 agaaatcgcc gacctcttga tcgatcaaat tgagttttgc gatgtactga tcttaaataa 348181 atgtgatttg gtcagcgagc aagagctcga acagcttgaa aacgttcttc gtaaactgca 348241 gccaagagcc aggttcattc gttccgtcaa aggaaatgta aaaccgcagg agattttgca 348301 tacagggtta tttaacttcg aggaagcgag cggatcggcc ggctggattc aagagctgac 348361 ggcaggccat gcggaacaca ccccggaaac agaagaatac ggtatctctt catttgtata 348421 taagagacgt ttgccgtttc attctacacg attttaccgt tggttggatc aaatgccaaa 348481 gaacgtggta cgtgccaaag gaatcgtctg gtgcgcatct cataacaacc tcgctttgct 348541 gatgtcgcaa gcaggtccgt cggttacgat tgagcctgta tcttattggg tggcggcgtt 348601 gccgaagctt gagcaggagc aagtcaaaca gcaggagccg gaaatcctgg aggagtggga 348661 cccggagttc ggcgaccgcc taacgcagct agtttttatc ggaactgacc tggatgaaga 348721 aacgatcacg aaagagcttg atcaatgcct gttgactgag tatgaatttg attccgactg 348781 gtcgctgttt gaggacccgt ttaaatggaa gctgaatcaa tagaaaaaaa gccgtcccat 348841 ggggaacggc tttttttaat gaaacgtttg tttaaacata atgagcgtat tttttctcaa 348901 ggatattctg aaagaccgcg gcaatggagc agatggccca ataaatgaga gcggtcagaa 348961 tatacatggt catataatca aactctctgc ccccgatgat tttcgcatgc tggagcaatt 349021 ccggcactgt aatcatcgca gcgagagagg acgccttgat caagtcgagc aatacattgg 349081 caagcggagg cagcgcaata cgtatcgatt gcggcaaaat gatgcccctc atcgtctgcc 349141 aataggaaag acccagcgag gatgcggctt cccactgtcc tttttcgacg gatgaaatgg 349201 ctgaacggtt aatttccgca atgtaggcgg cgctgtttag gctaaagccg attaaagcag 349261 ccgtgacagc ggaaaattca atgccgatat aaggaaaccc gaaataaagg ataaacaaaa 349321 tcaccaaaat cggaacgcct cgcataaatg agatatagag cttcgccggc catcttaaca 349381 aagcaagttt agacattctg gcgagtgata tgaacaggcc gatcacagtt cccgcaaaca 349441 tgcttacaaa agagatgagc agtgtataac caatgccttt tatgacataa gggaacgatt 349501 caatggccag cttcgtgttg aaaatatatt cccactgaat gctattgatc atggcgtccg 349561 attacaaatc aacgtcctga acgtcggcat caattttttt tgatacatct gctttattga 349621 agaattgttt cgacagttta gtcaaagagc catccttgct catctctttc aatgcttcgt 349681 tcatcttttt ctgaagtgcc gcattgcttt ttttcatgac aagggcctgt ttgttcggca 349741 tgtacttgat gtcaggatga attgtaatgt tgagatccgg gaatgccgcg agcgcaagtg 349801 tctgcaggta atagtcgttt aaaatgacgt cagtgcgtcc gttggcaaca tcttttaaat 349861 attgctcatt cgtcgcatta tcataaatca cttctttggc gccgtatttt ctcgcgacct 349921 ccatgtagac ggttgtagcc gcgccagccg ctttcttccc ttttaaatcc ttgagcgttt 349981 taatccctga taaatcgtct tttcggacaa ttgccgtgcc gtatgaatat ttatatggag 350041 tggaaaatgc gaacttctcc tcacggtcct tcgtcacatc gatgtcattc gcggctgcgt 350101 caacctgtcc gctgttcacc gctgtcagca tcccgtcaat gcccatctcc ttgaactcaa 350161 ccttcagccc caagcgtttt gccgcttcac gaacaacttc aacctcgtag cccgtcagct 350221 tatcagagcc agagtcagta tcgtgataag aagtgggata gagcgtacct gatgtagcga 350281 ctacgatttt ccctttatcc ttaatctgct cccagcctgt atccttggaa tcggcttcat 350341 ttttgccgga acaggctgcc aatataagaa agaaagccat tgtgaaactg aatataacgg 350401 ctttggaatg catgaatgat ttcacctata gttcccccaa tctgttaatc aactaaaaag 350461 atagcattga acataagggg ttgcaatatg ttgatcgcgt tttcaaaaag ttcgaattgt 350521 gtatacaaaa agcatgggtg ggtgtttaaa agcgtctatg aagggaagag gtgatgaaaa 350581 aaggaattgt ccaaggatga atgccagacg taccaaggaa acgcatgtga aagtgaagga 350641 tgcagcagac ccgtcactca tctatgccaa taccggaaga aatggtcaag aggcatgaaa 350701 ccgatcttca gaataaattt aagtcttgct gatgccccta aggcatatga tatattcgat 350761 gagaaagaaa atggaaacat ttaaaccata atggggagtc aaatgaatat ttacaaacca 350821 gccggatttt ggatcagact tggagctgca ttgttagact acattatagt ctccgtgccg 350881 cttttgctga tctattggct gattacagga aaagacccaa acgacagcat gttcatcagt 350941 ttggttgttc tgctgtattc tattttgctg ccgatgtttt ggcgcggtta tcttatcgga 351001 aaaaggatct gcggaatcag aatcgtaaaa aaagacggat cacaggtcag tctgttaaca 351061 atgtttttac gggttattgt agccggcctg gtttactgta taaccttcgg actcggcttg 351121 atcgccagcc tgattctgat tgccgtacga gaagacaaac ggaccctgca tgatttaatc 351181 gcgggaacat atgtcactta tgcgacacca ggtgaagagg aacttaatgc tgacgaagag 351241 attagaaaga gcgaataatg gttcgctctt tttattttta tgcataaaaa atacaaggca 351301 gcaaaacata tgaaaaatag gattggagga ataaaatgga tgaaacgaat aaccatcaac 351361 attatcacaa tgttcattgc agcggctgtc atttctctga ccggtacagc tgaggccgct 351421 gaaaaacagc agcagtctcc cgcaaatgtt acactgacag atcagcaaaa gaaagagatt 351481 gaacaactgg aagcagagat tcttaaaaag cgcaaagacg tgatctcaaa gtatgtacaa 351541 tacggtatcc tgcctaaaga aagaggagaa cacatcaaaa atcacttgga caaacacttt 351601 gaaatgatga aacaaaacgg ctttgttcca aagcaccatc ctcatccgca taaatttgaa 351661 aaaagacatt aagattttaa gcatccaatg ggaattgggt gcttttgcgt tatttacagg 351721 taggcaatat tagctgagct gttccgcgac taacatcgag ttgatatgaa acgcgtttca 351781 tagcctatga taggtttatc aaataattca ggagtgataa acactatgat ccaccagcat 351841 ccagaatctt ttccgaaaca ttttttgtgg ggctctgctt ctgcagcgta ccagattgaa 351901 ggcgcttgga atgaagatgg caaaggccct tctgtttggg atgtgtttac gaaaataccg 351961 ggcaaaacgt ttaaaggaac caatggcgag attgcggttg accattatca ccgatttaaa 352021 gaagatgtcg ctctgatggc tgagatgggg ttaaaagcat atcgattttc cgtcagctgg 352081 ccacgggttt ttccaaaagg aaaaggagag atcaatgaag caggtctagc gttttacgat 352141 agtctgattg atgaattgct ttctcatcac atcgagccgg ttctgacttt atatcactgg 352201 gatttgcctc aagcgcttat ggacgaatac ggcgggtttg aatccagaaa catcatagag 352261 gattttaatc actactgtat tactctttat aaacgttttg gagacagggt gaaatattgg 352321 gttacgttaa acgaacagaa ctacaatttt aatcacggat ttattacagc catgcatccg 352381 cctggagtga aagacagaaa acgattttac gaagcaaacc atattgcgtt tctggctaat 352441 gcaaaagcca tcgaatcatt tagagaatat gtgcctgaag gcaaaatagg tcctagcttt 352501 gcttattctc cggcttaccc tttatcaagt catccagagg atatactggc atttgaaaac 352561 gccgaagaat ttacgaacaa ttggtggctt gacatgtatt gctggggaac ctacccgcaa 352621 attccattcc gctgcttgga aaaacaggga tgggcgccga caattgaagc aggagatatg 352681 gacctgctcg ccaaagggaa gcctgatttt gtaggtgtca attattatca gacgatcacc 352741 tatgaacgaa atccgcttga tggtgtgtca gaagggaaaa tgaatacgac aggccaaaag 352801 ggaaccaatc aggagacggg gatacccgga gtgttcaaaa cgaaaaaaaa tccgcatctg 352861 acaacgagca actgggattg gacaattgac ccaattgggc tgcgtatcgg tcttcgccga 352921 attacaagcc gctatcagct tccagtgttt ataacagaga acggtttggg tgaatttgat 352981 aaagttgagg acggcactgt acaggatgat tatcgaattg attatttgcg ttcgcatctt 353041 gagcaatgca gacaagccat cagtgacggt gtcgatttaa tcggctattg cagctggtcg 353101 tttactgatc tgttaagctg gctgaacggc taccaaaaaa gatacggatt tgtatatgtc 353161 aatcgtgatg aagaaagcac atccgattta aaacgcttga agaaaaaaag cttttattgg 353221 tatcaagatg tcatcaagac aaacggagaa agtttataaa gagtccctga gagttattct 353281 ctcaggggtt tttcattaca cagaaacagc atcaataata taagtgtcgg cgtgcaaatc 353341 tgacatttca gccggcacag tccagcatgt caattgatag tctcctttag gcagatcaaa 353401 ggacagtctt ttagacatga tgctttcaat atgaattccg ttttctgtga catgaaaagg 353461 aacagtcact tttttttcgt aggagtttac tgtttctgaa ctgttcaggc gaaaaagaat 353521 aaaggccttt gtatttcgct gtgcctcaaa ggaaatggct ccgtctgccg cagcatatcc 353581 tttttcaatc gcttcgtcag tccaatccat tacaggaggt gtagaatcct tttgaaatac 353641 agtaaattga tgatatgaaa tcgaaagttc ttgcggcttc catgatttga tcaatgtgct 353701 gttcctcctc tatgtactgt ttactgaatt gtgaataaaa cctttgtgcc gtctgggtaa 353761 tcggtaagcc gatgcccgac ccaagagcct gctccgcggt tgtcagcggg agaaatgtat 353821 tctacagaag ctccctcacc gccttctttg cacatggcca ttggccattc atctctgtca 353881 tacccctttt tggaaggtac gtcctttaat gattgctcgc ggcgttcttc agctccgtct 353941 ctgtcaatag tgcacacctc tgagtgcccc tcatttatcg catccttaat atgcttggca 354001 gtttcgggat accggtcaga tgggaaggcc attgtttcat catattcttt cgtttgagac 354061 gttttttgat cagctgagaa aaagtctcct tttatcaggc cgacagctgc agctgctatg 354121 atgacgatga cgagaagtat cgtttttatg atgtccgtcg tgatgttcac ctcccgcttt 354181 taaaactgac acaagagtaa tccagaaagc atttggtgta aaggtttaaa ttttatgttt 354241 tacgatcagt ttattgcaga aatcgtaatt ttagcagatc gaaatatttg ttttcagcaa 354301 aatacgattg ccaatttaca ataatgatag taagtcatca gccgttttcg gcttgattaa 354361 tcattttaaa ttggcttatg ataccggtaa gctcctcagc taattgagaa agtgtttcag 354421 aagctgcggt aatctcctcc attgcagcaa attgctcctc tgttaatgca gccgcttgcc 354481 gggtattttt agtagattct ttaatgtcgg ccgtattggc tgcaaaggaa tcatttattt 354541 gatgtgcact ggctgaaatg tttgttacag atgctgataa atcactaatc tcggcgctga 354601 tttcacctgt tgcagctgca atttccttaa atgcatctct ggtgcgctgg atcatggtga 354661 ctccttctgc agcttctgtt ttcacatgct caacagatct tgcagaccgg ttcatatcct 354721 tttgtatttc tatgatcagt tttgaaatct gccccgcaga ctgttgagac tcttctgcta 354781 atttccgtac ttcatcagca acaacagcaa agccttttcc ttgttcaccg gctctggcag 354841 cttcaatcgc tgcattcagc gcaagcaggt ttgtctgatc agcaatttgg gtgatgaccg 354901 ataaaatttg ctcaatttgt ttagagcggc cgtctaactg gtgtatgatt tctccgcttt 354961 tctgaattga ctggtgaatc gcatccattt gcgcctgtac atttgcaatt tccttttgtc 355021 caatgtctgc ttttgattga gcgagctgcc ctttgtcagc gatagcggca gtatttgcag 355081 aaatatcccg gatgtctgct gaagcttgtt ttaatgagct ttcactattt tcaattcggg 355141 tgatctgatc ttgggctcca tttgcaatct gctgtacagc ttctgtgatt ttttctgaag 355201 cttgatttgt ttcctctgct ccggctgaga gctgctgaga ggctgacgca agctgaaggg 355261 ctgattgttg tacggtttgt atggtatcgt tcagcttcat tctcatctta ttataataga 355321 cgcttagttc tgaaagctcg tcaccggttt tgtctgacac ctctattgtc atatctccgt 355381 ttccggcact ttcaaaggcg ctttttaaag cgttcagccg cttgttgatt tttctggtga 355441 aaaccaagac aaggatgact gataccataa tgacgataac aagaacgata gcgaattgag 355501 tgaaaagtga ttgtgtaagt gatgctaaaa tactttgatt agctccggta tacagcatgc 355561 cgatgatgtt cccattttga tcttttaacg gcatgtatgc agtctgataa gaagaacctg 355621 ctacatctgc ttgtccgtaa aaacgctttc ctttctttaa aacagcggca ataacttcag 355681 aagaagcctg ggtgccgacg gctctttcgc catttttcat gacattggtt gcaacacgag 355741 tatcgccttg gaaaatggta atggtatcac ctgtcttttc accaagcaga tcaacaatat 355801 cttcatttcc attgatttgt gtttgccctt tatagagctt attgtttttc acctgccagt 355861 cgcctgacat gacatcatca atataagtgc tgcttaaagc gagatcacct ttcgcttttt 355921 cagttgccat ttgtttcatg ctttctgtaa tttccttaag catcacagtg ccaactgatg 355981 ccgaaaacaa aagaatcacc acgaaaacga ggcaaagaat tttagttcct agcttcatct 356041 taaatcgttt tatcaacata attcctccct ttacgatttg caggtcatat tacttatcgg 356101 gtttttgggt ttaaagtttt attttagaaa aaataaaacc ggcctgatct tcaggccggt 356161 tgtgtgatgc tattcaaggt ttgcgtggtg agtgaacata gtttcagaat cgagaccttt 356221 tttctccatg agttttaaaa tcactgcatc atagaagagc agcaaagttt gttcaaataa 356281 tgatcccatt ggctgaatgg ttttatagct tccgttagac tggtctttag gggaaccagg 356341 cattctgatg atgaggtccg cttgttttcc gatgcttgat tccggattga tggttaaagc 356401 ggcaacaatt ccgtgtaagc tttttgcttt tgctgcggta tgaatcaagc tctttgtctc 356461 gcctgatcct gagccgataa taactagatc tccttcggcg agcggcggag tgagaatctc 356521 acctactata tgggcgttga agcccatgtg catcagtctc atcgcgaagg attttgccat 356581 caggccagac cgccccgcac ccgcggtgaa aatttggtgg gatgaaagaa tgtgatcggc 356641 aagctggtca gcttcttcat tagaaatata agctgctgaa ttgtgtaact cattgagaat 356701 ttccgctacg tattcagtcg ttttcatcgg agttatcctt ggacaatcag ctgcttcatt 356761 tttgaagctg tttccgcctt atcagctgcg cttgtaattc cgcccccgac aatgacaagg 356821 tcaggctttt gctggatcac ttctggcagt gtatcaagtt tgatgccgcc cgcgattgcg 356881 gtttttgcgt tttttacggt atttttgatt gtcgttaatt cttcgaaaga gtttttgccc 356941 tctgcttgaa gatcatagcc agtgtggacg cagatgtagt caacaccgag tgcgtcaatt 357001 tctttcgcac gggattcgat atctttcacg ttaatcatgt ccactaagat tttcttcttt 357061 tgttttttgg cttcttctac tgcgccttta atcgttgcat cgtctgtagc ccctaaaacg 357121 gtgatgatgt cagcgcctgc ttccgacgct ttcataattt cgtagcctcc ggcatccatg 357181 attttcaggt ctgcaagaac cttcaattga ggaaatgctt cttttatttc tttaacggct 357241 cttaggcctt cattgatgac gaccggtgtt ccgatttcaa ctacgtcgat gtattgttct 357301 acctctttga caagctcaat ggcttccggg atgttgacga ggtctaatgc aagctgtaat 357361 tccattgttg atccactccc tttttcgaat tattgttcat tctataggtt ccttcttttg 357421 ttgagaagta ggcactttga agtcaacaag ttacttggag gatactgtga ggagagacaa 357481 tcagatttct ttcgcttgat tttatgagtg agtataatga aaaaagagtc tgcaaaaaag 357541 taagtaagtg atgatacgta tctaacatac aaaaaggtta ctaagggggg ggattctatt 357601 gagccggatg gacgacaaaa ggtttaattg tgagaaggaa ttaacgcttg cagtgattgg 357661 cggtaaatgg aaaatgctca ttttatggca tttaggaaaa gaaggcacaa aacggttcaa 357721 tgaattaaaa acattgattc ctgatattac gcagaagatc ctcgtgaatc agctgagaga 357781 gcttgagcag gatatgattg ttcacaggga agtgtatcca gttgtcccgc cgaaggttga 357841 atattctctg accccgcacg gagaaagcct catgcctatt cttgaagcca tgtatgagtg 357901 ggggaaaggc tatatggaat tgattgatat cgacaaaaat gtcatgaaag aatcgttgta 357961 agacgctctt cgcaagggtg tctttttttg cctttttttc ggtttttgcg cggtacacat 358021 agtcatgtaa agattgtaaa ttgcattcag caataaaaaa agattgaacg cagcagtttg 358081 gtttaaaaat ttttattttt ctgtaaataa tgtttagtgg aaatgattgc ggcatcccgc 358141 aaaaaatatt gctgtaaata aactggaatc tttcggcatc ccgcatgaaa cttttcaccc 358201 atttttcggt gataaaaaca tttttttcat ttaaactgaa cggtagaaag ataaaaaata 358261 ttgaaaacaa tgaataaata gccaaaattg gtttcttatt agggtggggt cttgcggtct 358321 ttatccgctt atgttaaacg ccgcaatgct gactgacggc agcctgcttt aatagcggcc 358381 atctgttttt tgattggaag cactgctttt taagtgtagt actttgggct atttcggctg 358441 ttagttcata agaattaaaa gctgatatgg ataagaaaga gaaaatgcgt tgcacatgtt 358501 cactgcttat aaagattagg ggaggtatga caatatggaa ataacttttt accctttaac 358561 ggatgcacaa aaacgaattt ggtacacaga aaaattttat cctcacacga gcatttcaaa 358621 tcttgcgggg attggtaagc tggtttcagc tgatgcgatt gattatgtgc ttgttgagca 358681 ggcgattcaa gagtttattc gcagaaatga cgccatgcgc cttcggttgc ggctagatga 358741 aaacggggag cctgttcaat atattagcga gtatcggcct gttgatataa aacatactga 358801 cactactgaa gatccgaatg cgatagagtt tatttcacaa tggagccggg aggaaacgaa 358861 gaaacctttg ccgctatacg attgtgattt gttccgtttt tccttgttca ccataaagga 358921 aaatgaagtg tggttttacg caaatgttca tcacgtgatt tctgatggta tctccatgaa 358981 tattctcggg aatgcgatca tgcacattta tttagaatta gccagcggct cagagacaaa 359041 agaaggaatc tcgcattcat ttatcgatca tgttttatct gaacaggaat atgctcaatc 359101 gaagcggttt gaaaaggaca aggcgttttg gaacaaacaa tttgaatcgg tgcctgaact 359161 tgtttccttg aaacggaatg catccgcagg gggaagttta gatgctgaga ggttctctaa 359221 agatgtgcct gaagcgcttc atcagcagat tctgtcgttt tgtgaggcga ataaagtcag 359281 tgttctttcg gtatttcaat cgctgctcgc cgcctatttg tacagggtca gcggccagaa 359341 tgatgttgtg acgggaacat ttatgggcaa ccggacaaat gcgaaagaga agcagatgct 359401 tggcatgttt gtttctacgg ttccgcttcg gacaaacatt gacggcgggc aggcgttttc 359461 agaatttgtc aaagaccgga tgaaggatct gatgaagaca cttcgccacc aaaagtatcc 359521 gtataatctc ctaatcaacg atttgcgtga aacaaagagc tctctgacca agctgttcac 359581 ggtttctctt gaatatcaag tgatgcagtg gcagaaagaa gaggatcttg cctttttgac 359641 tgagccgatt ttcagcggca gcggattaaa tgatgtctca attcatgtaa aggatcgatg 359701 ggatactggg aaactcacca tagattttga ttaccgcact gatttatttt cacgtgaaga 359761 aatcaacatg atttgtgagc gcatgattac catgctggag aacgcgttaa cgcatccaga 359821 acatacaatt gatgaattaa cactgatttc tgatgcggag aaagagaagc tgcttgcgag 359881 ggccggcggt aaatctgtga gctaccgtaa ggacatgacg ataccagagc tgttccaaga 359941 aaaggctgaa ctgctttctg atcatccagc ggttgtattt gaagatcgca cattgtccta 360001 tcgaacgtta catgagcaat ctgcacgcat cgccaatgtg ctgaaacaga aaggggttgg 360061 cccggacagt cctgtcgcgg ttttgattga acgctctgaa cggatgatta cagctatcat 360121 gggaatttta aaagccggcg gagcctatgt gccgattgat ccgggttttc ctgctgagcg 360181 cattcaatat attttggagg actgcggggc ggatttcatc ctgactgaat cgaaggttgc 360241 ggcgcctgaa gccgatgctg agctgattga cttagatcag gcgattgagg aaggtgcaga 360301 agaaagcctg aatgcagatg tgaacgctcg gaaccttgcc tacattattt acacatcggg 360361 aacaaccgga cgcccgaaag gcgttatgat cgagcatcgc caggttcatc atttggttga 360421 atctctgcag cagacgattt atcaaagcgg cagccaaacc ctgcggatgg cattgcttgc 360481 gccgttccac tttgatgcgt cagtgaagca gatcttcgcg tcgcttcttt tgggccaaac 360541 cctttatatc gtaccgaaga aaacagtgac gaacggggcc gcccttactg catattatcg 360601 gaagaacagc attgaggcga cggacggaac accggctcat ttgcaaatgc tggcagcagc 360661 aggcgatttt gaaggcctaa aactgaagca catgctgatc ggaggagaag gcctgtcatc 360721 tgttgttgcg gacaagctgc tgaagctgtt taaagaagcc ggcacagcgc cgcgtttgac 360781 taatgtgtac gggccgactg aaacgtgcgt tgacgcgtct gttcatccgg ttatccctga 360841 gaatgcagtt caatcagcgt atgtgccgat cgggaaagcg ctggggaata accgcttata 360901 tattttggat caaaaaggcc ggctgcagcc tgaaggcgtg gcgggtgagc tttatatcgc 360961 gggagacggt gtgggccgag gctatttaca tttgcctgaa ttaacggaag agaagttttt 361021 acaagatcca ttcgtgccgg gcgatcgcat gtaccggacc ggggacgtgg tgcgctggct 361081 tccagatgga acaatcgaat atttaggcag agaggatgac caggtcaaag tccgcggata 361141 ccggattgag cttggggaaa ttgaagccgt gattcagcag gcgccagacg ttgcaaaagc 361201 cgttgttttg gcacgccctg acgaacaggg aaatcttgag gtttgcgcat atgttgtgca 361261 gaagcctgga agcgaatttg cgccagccgg tttgagggag catgcggcca gacagcttcc 361321 tgactatatg gtgccggctt actttacaga agtgacagaa attccgctta caccaagcgg 361381 caaagtcgac cgccgcaagc tgtttgcact agaggtgaag gctgtcagcg gcactgccta 361441 tacagcgccg cgaaatgaga ctgaaaaagc aatcgcagcc atttggcagg acgtgctgaa 361501 cgttgagaag gcggggatct ttgacaattt ctttgaaact ggcggacatt cattaaaagc 361561 catgaccctt ttaacaaaga ttcataagga aacaggcatt gagattccgc ttcaattttt 361621 gtttgagcat ccgacgatta cggctcttgc agaggaagct gatcacagag aaagcaaagc 361681 ttttgcggtg attgaacctg ctgaaaaaca ggagcattac ccgctttcat tggcacagca 361741 gcgaacatat atcgtcagcc agttcgagga tgcgggagtc ggctataaca tgccagcagc 361801 agcaattctg gaagggcctt tagatattca aaagctggag cgcgcatttc agggattaat 361861 ccgacgccac gagtcattga gaacatcatt tgttcttgaa aacagcacgc cgagacagaa 361921 aattcacgat agcgttgatt tcaacatcga aatgattgaa agaggcggcc gctcagatga 361981 ggcaattatg gcttcattcg ttcggacatt tgatttggcg aaagctccgc tgttcagaat 362041 cggtttgctg gggcttgaag agaaccgtca tatgctgctg tttgacatgc accatttgat 362101 ttctgacggt gtatccattg gcattatgct ggaggagtta gcacgcattt ataaaggcga 362161 acagcttcct gatcttcgtc tccagtataa ggactacgct gtatggcaaa gcagacaggc 362221 tgctgaaggg tacaagaagg accaggctta ttggaaggaa gtctttgcag gcgagctccc 362281 ggtgcttcag cttctgtccg attacccaag accacctgtt caaagctttg aaggggatcg 362341 ggtgtcaatc aagctggatg cgggggtaaa ggatcgcctc aatcgtttgg ctgaacaaaa 362401 cggcgccact ttatatatgg tgatgctttc cgcttactat acgcttttgt caaagtatac 362461 ggggcaggat gacatcattg tcgggacacc gtcagcgggc agaaatcact ccgatacaga 362521 gggcattatc gggatgttcg tcaatacgct tgcgattcgc agtgaggtga agcagaatga 362581 gacgtttacc caattgatct cgcgtgtccg caaacgggtg ctggatgcct tttctcatca 362641 ggactatccg tttgagtggc ttgttgaaga tttgaacatc ccgcgtgatg ttagcaggca 362701 tccgctgttt gacacgatgt tcagccttca aaacgcgaca gagggcattc cggctgtcgg 362761 cgatctttcc ttgtctgttc aagagaccaa tttcaagatt gccaaatttg atttgacggt 362821 gcaggcgaga gaaaccgatg aaggcattga gattgatgtg gattacagca caaagctgtt 362881 taaacaaagc acggcagaca ggctgcttac gcattttgcg cgtttgcttg aagatgctgc 362941 ggctgatcca gagaagccga tttctgagta taagcttctt tctgaagagg aggctgcttc 363001 gcaaattcag cagtttaacc cgggcagaac accttatccg aaagataaaa caattgttca 363061 gctgtttgag gagcaagcgg cgaatacgcc agaccacact gcgcttcaat atgaaggcga 363121 atcactcact tatcgtgaac tgaatgaacg ggccaatcgt ttagcccgcg gcattctttc 363181 tcttggagct ggcgaaggca gaactgcggc tgtcttatgc gagcggtcaa tggatatgat 363241 tgtgtcgatc ttggcagtat taaaatcagg ttcggcttat gttccgatcg atccggaaca 363301 tccgattcag cggatgcagc atttcttccg tgacagcgga gcaaaggtgc ttctcactca 363361 gaggaaatta aaggctttgg cggaagaagc ggaatttaag ggcgttatcg tgctagccga 363421 tgaggaagaa agctatcatg ccgatgcgcg aaatctcgca ctgcctcttg attctgcagc 363481 aatggccaac ctgacgtata cttccggaac gactggaaca cctaagggga atatcgtgac 363541 acatgccaat attctccgca cggtgaagga aacgaattat ctcagcatta cagaacagga 363601 tacgattctc ggtctttcca attacgtgtt tgacgcgttt atgttcgata tgttcggctc 363661 tttgttaaac ggagccaagc tggtgctgat accgaaggaa accgttttgg acatggctcg 363721 cctgtcccgc gtcattgaac gggagaacat cagcattctc atgattacaa ccgctttgtt 363781 ccacttgctt gtggacttga atccggcatg cttgtcaacg cttcgcaaga ttatgtttgg 363841 cggggaacgg gcttcggttg agcatgtcag aaaagctttg caaacggttg gaaagggcaa 363901 gctccttcat atgtatggac cgtctgaaag cacggttttc gcgacgtatc atccggttga 363961 tgaattggag gagcacacgc tgtctgttcc gattggaaaa ccggtcagca atacggaagt 364021 atacattctt gaccgtacgg gacacgtgca gcctgccggg attgccggag agctttgcgt 364081 cagcggcgaa ggactcgtga aaggctatta caaccgtcca gaactgactg aggagaaatt 364141 tgttccccat ccgtttacat ccggcgaacg catgtataaa acgggagacc ttgcgagatg 364201 gctgccgaat ggcgacatcg aatttatcgg gcgaatcgac catcaggtga agattcgcgg 364261 acagcgcatc gagcttggag aaatcgaaca tcagctgcaa acccatgatc gtgttcagga 364321 aagtgttgtg cttgccgttg atcaaggagc gggagataaa ctgttgtgtg cttactatgt 364381 cggagaagga gacatctcat cacaagagat gagagagcat gctgcgaagg acttgccggc 364441 atatatggtt cctgcggtgt ttatccaaat ggacgagctg ccgctgacag ggaacggaaa 364501 aattgaccgg agagcgctgc cgattcctga tgccaacgtt tcaagaggtg tttcatatgt 364561 tgcgccacgc aatggaacgg aacaaaaagt cgcggacatt tgggcacagg tacttcaggc 364621 agaacaagtc ggcgcttatg accacttctt tgacattggc ggacattcat tagcaggcat 364681 gaagatgctt gccttggttc atcaggaact gggcgttgag ctgtcactca aggatctctt 364741 ccagtcaccg acggttgagg gcttggcaca ggtgattgcc tctgctgaaa aagggacagc 364801 cgcaagtatc agcccggcag agaaacaaga tacgtatcct gtttcttcac cgcaaaaacg 364861 gatgtacgtg cttcagcagc ttgaggatgc gcaaacgagc tataacatgc cggcggttct 364921 gcgcctgaca ggtgagcttg atgttgaaag gcttaacagc gtcatgcagc agttaatgca 364981 gcgtcatgaa gccttgagaa ccacgtttga aataaaagat ggagaaacgg tgcagcggat 365041 ctgggaagag gctgagtgcg agatagccta tttcgaagcc ccggaagaag agacagagcg 365101 gatcgtttct gagtttatta agcctttcaa aatcgaccaa cttccactgt tcagaatagg 365161 gcttatcaag cattcagaca ctgagcatgt gctgctgttc gatatgcatc atattatttc 365221 tgatggtgca tctgtcggtg tgctgattga ggagctttca aagctgtacg acggagaaac 365281 ccttgagccg ctccgtattc aatataagga ttatgccgtg tggcagcagc agttcattca 365341 gtctgagctt tacaagaagc aagaagagca ttggctgaag gagctggacg gagagctgcc 365401 ggtgctgacg cttccgactg attacagtcg gcctgccgtt caaacatttg agggagaccg 365461 cattgcattt tcattagaag caggcaaagc tgatgctctg cgcaggcttg caaaagaaac 365521 ggattccacg ctttacatgg tgcttctggc ttcatacagt gcgtttttat caaaaattag 365581 cgggcaagac gatatcatcg tcggttcacc tgtggccgga cgatctcaag cggacgtcag 365641 ccgcgtcatc ggaatgttcg tcaatacatt ggcgctgcgc acgtatccga agggtgaaaa 365701 gacgtttgct gactatctta acgaagtgaa agaaacggca ctcagcgctt ttgatgcgca 365761 ggattaccca cttgaggatt tgatcggaaa tgttcaggtt cagcgtgaca caagcagaaa 365821 tccgttattc gatgcagttt tttcaatgca aaatgcgaat ataaaggatt taacaatgaa 365881 agggattcag cttgagccgc atccgtttga acggaaaaca gccaagtttg acctcacgct 365941 gacggctgac gaaaccgacg gagggcttac attcgtactc gaatacaata cagctctgtt 366001 taagcaggaa acgattgaac gatggaagca atattggatg gagcttttag atgcagttac 366061 tgggaacccg aaccagccgc tttccagcct gtcactggtc accgagacag aaaagcaagc 366121 gcttcttgag gcatggaagg gcaaagcgct gcctgtgccg acagacaaaa cggttcatca 366181 gctattcgaa gagactgccc agcgccacaa agaccgcccg gctgtcacat acaacggcca 366241 gtcttggacg tacggcgagc tgaatgcgaa ggcaaaccgt ctcgcgcgga ttctgatgga 366301 ctgcggcatc agcccggatg accgcgtcgg cgttctcacg aagccgtcgc ttgaaatgtc 366361 cgccgcggtg ctcggcgtct tgaaagccgg agcggcgttt gtgccgattg atcctgacta 366421 tccggatcag cggattgagt atattttaca ggacagcggc gcgaagcttc tcttgaaaca 366481 ggaaggcatt tcagtgccgg acagctatac gggagatgtc attcttctcg acggaagccg 366541 cacgattcta agcctgccgc ttgatgaaaa cgacgaggaa aatccagaaa ccgctgtaac 366601 cgcggagaac ttggcgtaca tgatttacac gtctggaacg accggacagc cgaagggtgt 366661 catggtcgag caccatgcgc ttgtgaacct gtgcttctgg caccacgacg cgttcagcat 366721 gacagcggag gaccgcagtg cgaagtacgc gggctttggg ttcgacgctt ccatttggga 366781 gatgttcccg acctggacga tcggtgccga acttcacgtc attgaggaag cgatccgcct 366841 cgatatcgtc cgcctgaacg attattttga aacgaacggc gtaacgatca cgttcctgcc 366901 gacacagctt gcggaacagt tcatggagct tgagaacaca tcacttcgcg tattgcttac 366961 tggaggagac aagctgaagc gcgcagtgaa aaagccgtac acactcgtca ataactacgg 367021 gccgacagag aatacggtcg ttgccacaag cgcagaaatc catccggagg aaggctcgct 367081 ttccatcgga agggccattg ccaatacgag agtatacatt ctcggcgagg gcaatcaggt 367141 gcagccggaa ggcgtagccg gagagctttg cgtggcgggg cgcggactgg cacgcggcta 367201 tctgaatcga gaagacgaaa ccgcgaagcg gtttgtcgct gatccgtttg tgccgggtga 367261 gcgcatgtac cgcaccggcg atttggtgaa atggacgggc ggcggcatcg aatacatcgg 367321 ccggatcgac cagcaggtca aggtccgcgg ctaccggatc gagctctcag aaattgaagt 367381 ccagctcgcc cagctttctg aggtgcagga tgcggcggtg acagctgtca aagataaagg 367441 cggcaacaca gcgatcgcgg cgtatgtcac accggaatca gctgacatag aagcactgaa 367501 atcagcactg aaggaaaccc tgccggatta catgatcccg gcgttctggg tgacgctgaa 367561 cgagcttccg gttacggcaa acggcaaagt ggaccgcaaa gccttgcctg agccggacat 367621 cgaagcggga agcggagaat acaaagcgcc gacgaccgac atggaagagc tgcttgccgg 367681 catctggcag gacgtgcttg gaatgtctga agtcggtgtc accgacaatt tcttctcgct 367741 tggcggagat tccatcaaag gaattcaaat ggcgagccgc ttgaaccagc acggctggaa 367801 gctggaaatg aaagatctct tccagcaccc gacgatcgaa gagctcaccc agtacgtaga 367861 gcgtgccgaa ggcaaacagg cagaccaagg cccggtggag ggcgaagtca tcctgacgcc 367921 gatccagcgc tggttctttg aaaagaactt cacgaacaag caccactgga accaatctgt 367981 gatgcttcac gccaagaagg gctttgatcc tgaacgggtg gagaaaacat tgcaggcgct 368041 gatcgagcat catgacgcgc tccgcatggt ctatcgtgag ggacaggaag acgtcattca 368101 atacaacaga ggtcttgaag ctgcttcagc tcaattggag gtcatccaga ttgagggcca 368161 agctgcagat tacgaagacc gaatagagag agaagcggag cgtttgcaaa gcagcatcga 368221 cttgcaggaa ggcggcttgt taaaagcagg cttgttccaa gcggaagacg gagatcactt 368281 gcttcttgcc attcaccact tagtggttga cggcgtgtcg tggcggattt tactggagga 368341 tttcgccgcg gtatatacac agcttgagca aggcaatgaa ccggttctcc cgcagaaaac 368401 acattcattt gcagagtatg cagagagatt gcaagacttc gcgaactcca aagccttttt 368461 gaaagaaaaa gagtattgga gacagcttga agaacaagct gttgcggcaa agcttccgaa 368521 agaccgcgaa tctggtgatc agcgaatgaa acatacaaag acaattgaat tctcgctgac 368581 tgctgaagag acagaacagc tcaccacaaa ggtgcatgag gcatatcaca cagaaatgaa 368641 tgatattttg ctgacggcat tcggattggc aatgaaggag tggacgggtc aagatcgagt 368701 aagtgttcat ttagaggggc atggacgtga agaaatcata gaagacctga ccatttctcg 368761 cacagtcggc tggtttacaa gtatgtaccc aatggtgctc gatatgaagc atgcggatga 368821 tctgggctac cagctgaagc aaatgaaaga agatatcaga catgtgccga ataagggagt 368881 cggatacggc attctgcgct atctgacggc accggaacat aaagaagatg tggcgttctc 368941 gattcagccg gatgtcagct tcaactattt aggtcagttt gacgaaatgt cggatgcagg 369001 tttgtttacg agatcagagc tgccatcagg acagtcatta agccctgaaa cagaaaaacc 369061 gaatgcgctg gatgttgtcg gatatatcga aaacggaaaa ctgacgatgt cactggccta 369121 tcattctctt gaatttcatg aaaaaacagt acaaacattc agtgacagct ttaaagcgca 369181 tcttctcaga atcattgaac attgcctatc tcaagatggt acggaactga ccccgagtga 369241 tcttggtgac gacgatttga cgctggatga gctggataaa ttaatggaaa ttttctaata 369301 gaggtggcat atgagcaaaa aatcgattca aaaggtgtac gcactgacac caatgcagga 369361 gggaatgctg tatcatgcga tgcttgatcc gcattcttcc tcgtacttca cacaattaga 369421 gcttgggatt cacggcgctt ttgatcttga aatctttgag aaaagcgtca atgaactgat 369481 tcggtcatac gatattctcc gtacggtatt tgtgcatcag cagctgcaaa aaccgcgtca 369541 ggtcgtgtta gcggaacgca aaacaaaagt gcattatgag gatatcagtc atgcagacga 369601 aaaccgccag aaagagcaca ttgagcgtta caaacaagac gttcagcgcc aaggctttaa 369661 cctggcaaaa gacatattgt tcaaggtagc ggttttccgc cttgctgcag atcagctgta 369721 tcttgtctgg agcaatcatc atattatgat ggacggctgg agcatgggcg tcctcatgaa 369781 aagcctgttc caaaactatg aagcgctcag agcaggcagg acaccggcaa acggtcaggg 369841 caagccttat tccgattaca tcaagtggct tggaaaacag gacaatgaag aagcggagag 369901 ctactggagc gagcgcttgg cgggttttga acagccaagc gtgctcccgg gccgcctgcc 369961 tgtgaaaaaa gacgaatacg tcaataaaga atattcattt acatgggacg aaacactggt 370021 tgcccgtatt cagcaaaccg caaatctcca tcaagtgaca gggcctaacc tatttcaggc 370081 cgtttggggc attgttctca gcaaatacaa ctttacggat gatgtgatct tcggaacggt 370141 cgtctcggga cgaccgtctg aaatcaacgg aatcgaaacg atggcggggc tgtttatcaa 370201 caccattcca gtgcgggtga aagttgaacg agatgctgca ttcgctgata ttttcacagc 370261 tgttcagcag catgcagtag aggcagagcg ttacgattac gtgccgctct atgagattca 370321 aaaacgctca gctcttgatg gcaatctctt aaaccatctg gtcgcgtttg aaaattatcc 370381 gcttgatcaa gagcttgaaa acggcagcat ggaagaccgc ctcgggtttt cgattaaggt 370441 agaaagcgca tttgaacaaa cgagcttcga tttcaacctg attgtgtatc cgggcaaaac 370501 gtggaccgtc aaaattaaat ataacggagc cgcctttgat tccgctttta tcgaacggac 370561 agcggagcac cttacccgca tgatggaagc agctgtcgat cagccggccg cttttgtgcg 370621 tgagtacggg cttgtgggag acgaagagca gcggcaaatt gtcgaggtgt ttaacagcac 370681 gaaagccgaa ctccctgaag gaatggctgt tcaccaagtg tttgaagagc aagcgaaacg 370741 gacgccggcg agcaccgccg tcgtatatga aggaaccaag ctgacgtacc gcgagctgaa 370801 tgcagcggct aaccgtctgg cgagaaagct tgtcgaacat gggcttcaaa aaggggaaac 370861 agcagcgatt atgaacgacc gctcagtaga aaccgttgtc ggcatgctgg ctgttttaaa 370921 agcaggcgcc gcatatgtgc cgcttgatcc agcgcttcct ggggatcgtc ttcgtttcat 370981 ggcagaggac agctccgttc gaatggtttt gatcggaaat tcttatacag ggcaggcaca 371041 tcagctgcaa gtgccggttc ttacactgga cataggcttt gaagagagtg aagcggctga 371101 caatctcaac ctgccatccg ccccgtctga tttggcgtac atcatgtaca catccggttc 371161 aacgggcaaa ccgaaaggcg tcatgatcga acataaaagc attctgcgcc tcgtcaaaaa 371221 tgccgggtac gttcctgtta ctgaagaaga ccgcatggcg caaacgggag ctgtcagctt 371281 tgatgccgga acgtttgagg tattcggcgc actgctgaat ggcgcagcac tttatccggt 371341 caaaaaagag acactgcttg atgcgaaaca atttgctgca ttcctgcgtg agcaaagcat 371401 cacaactatg tggctgacat cacctttatt caaccagctt gctgcaaagg atgcgggtat 371461 gttcggcaca ctgcgccatt taatcatcgg cggagatgcc cttgtcccgc atattgtcag 371521 caaagtaaaa caggcatcgc cgtcgctttc attgtggaac ggatacggcc cgacagaaaa 371581 cacgacgttt tcaaccagtt ttctgatcga ccgcgagtat ggcggctcta tcccaatcgg 371641 gaagccgatc ggaaattcca ctgcctatat tatggatgag cagcaatgcc tgcagccaat 371701 cggcgcgcct ggtgagcttt gcgtaggcgg aatcggtgta gcgcgtgggt atgtcaatct 371761 ccctgagctg acggagaagc aatttctgga agacccgttc agaccgggtg agagaattta 371821 ccgcactggt gacttggcaa gatggctgcc ggacggcaat atcgaatttt taggcagaat 371881 cgacaaccaa gtgaaggtgc gcggcttccg aattgagctt ggcgaaattg aaacaaaact 371941 gaacatggct gagcatgtga cagaagccgc ggtgatcata cgcaagaaca aagcagacga 372001 aaatgaaatt tgcgcgtact tcacggcgga tcgtgaagtg gctgtgagtg agctgagaaa 372061 aacactgtct cagtctttgc ctgactatat ggtccctgcc cacctgattc aaatggacag 372121 cctgccgctc acgccaaacg ggaaaatcaa caaaaaggaa ctgcctgcac cgcaatcaga 372181 agccgtgcag ccggaatacg cagcaccaaa aacagagagt gaaaagaaat tagcggagat 372241 ctgggaagga atactcggcg tcaaagcagg cgttaccgat aacttcttta tgatcggcgg 372301 ccattctttg aaagcgatga tgatgacggc gaaaattcaa gagcattttc ataaggaagt 372361 tccgataaaa gtgctttttg aaaagccgac tattcaagaa ctggcactgt atttggaaga 372421 gaacgaaagc aaggaggagc agacgtttga accgatcagg caagcatctt atcagcagca 372481 ttatcctgta tccccggccc agcggagaat gtatatcctc aatcagcttg gacaagcaaa 372541 cacaagctac aacgtccccg ctgtacttct gctggaggga gaagtagata aagaccggct 372601 tgaaaacgcg attcagcaat taatcaaccg gcacgaaatc ctccgtacat cgtttgacat 372661 gatcgacgga gaggttgtgc aaaccgttca taaaaacata tcgttccagc tggaggctgc 372721 caagggacgg gaagaagacg cggaagagat aatcaaagca tttgttcagc cgtttgaatt 372781 aaaccgcgcg ccgctcgtcc gttcgaagct tgtccagctg gaagaaaaac gccacctgct 372841 gctcattgat atgcatcata ttattactga cggaagttca acaggcattc taatcggtga 372901 tcttgccaaa atatatcaag gcgcagatct ggaactgcca caaattcact ataaagatta 372961 cgcagtttgg cacaaagaac aaactaatta tcaaaaagat gaggaatact ggctcgatgt 373021 ctttaaaggc gaactgccaa tactggatct tcccgcggat ttcgagcggc cagctgaacg 373081 gagctttgcg ggagagcgcg tgatgtttgg gcttgataag caaatcacgg ctcaaatcaa 373141 atcgctcatg gcagaaacag atacgacaat gtacatgttt ttgctggcgg cgttcaatgt 373201 actcctttcc aagtacgcgt cacaggatga tatcattgtc ggctcgccga cagctggcag 373261 aacacatcct gatctgcaag gtgtgccggg tatgtttgtc aacacggtgg cactcagaac 373321 ggcaccagcg ggagataaaa ccttcgcgca attccttgaa gaggtcaaaa cagccagcct 373381 tcaagcattc gagcaccaga gctatccgct tgaggagctg attgaaaagc ttccgcttac 373441 aagggataca agcagaagtc cgctgttcag cgtgatgttc aacatgcaga atatggagat 373501 tccttcatta agattaggag atttgaagat ttcctcgtat tccatgcttc atcatgttgc 373561 gaaatttgat ctttccttgg aagcggtcga gcgtgaagag gatatcggcc taagctttga 373621 ctatgcgact gccttgttta aggacgagac gatccgccgc tggagccgcc actttgtcaa 373681 tatcatcaaa gcggccgcgg ctaatccgaa cgttcggctg tctgatgtag atctgctttc 373741 atctgcagaa acggctgctt tgctagaaga aagacatatg actcaaatta ccgaagcaac 373801 ctttgcagca ctttttgaaa aacaggccca gcaaacacct gaccattctg cggtgaaggc 373861 tggcggaaat ctgttgacct atcgcgagct tgatgaacag gcgaaccagc tggcgcatca 373921 tcttcgtgcc caaggggcag gaaatgaaga catcgtcgcg attgttatgg accggtcagc 373981 tgaagtcatg gtatccattc tcggtgtcat gaaggcgggg gcagctttcc ttccgattga 374041 tcctgataca cctgaagaac gaatccgtta ttcattagag gacagcggag caaaatttgc 374101 ggtcgtgaat gaaagaaaca tgacggctat tgggcaatat gaagggataa ttgtcagcct 374161 tgatgacggt aaatggagaa atgaaagcaa ggagcgccca tcatccattt ccgggtctcg 374221 caatcttgca tacgtcattt atacgtccgg tacgaccgga aagccaaagg gcgtgcagat 374281 tgagcatcgt aatctgacaa actatgtctc ttggtttagt gaagaggcgg gcctgacgga 374341 aaatgataag actgtattgc tttcatctta cgcatttgac cttggctata cgagcatgtt 374401 ccctgtactt ctgggcgggg gcgagctcca tatcgtccag aaggaaacct atacggcgcc 374461 ggatgaaata gcgcactata tcaaggagca tgggatcact tatatcaagc tgacaccgtc 374521 tctgttccat acaatagtga acaccgccag ttttgcaaaa gatgcgaact ttgaatcctt 374581 gcgcttgatc gtcttgggag gagaaaaaat catcccgact gatgttatcg ccttccgtaa 374641 gatgtatgga cataccgaat ttatcaatca ctacggcccg acagaagcaa cgatcggcgc 374701 catcgccggg cgggttgatc tgtatgagcc ggatgcattt gcgaaacgcc cgacaatcgg 374761 acgcccgatt gcgaatgccg gtgcgcttgt cttaaatgaa gcattgaagc ttgtgccgcc 374821 tggagcgagc ggacagctct atatcacggg acaggggctc gcgagagggt atctcaacag 374881 gcctcagctg acagccgaga gatttgtaga aaatccatat tcgccgggaa gcctcatgta 374941 caaaaccgga gatgtcgtac gaagactttc tgacggtacg cttgcattta tcggccgggc 375001 tgatgatcag gtgaaaatcc gaggctaccg cattgagccg aaagaaattg aaacggtcat 375061 gctcagcctc agcggaattc aagaagcggt tgtactagcg gtttccgagg gcggtcttca 375121 agagctttgc gcgtattata cgtcggatca agatattgaa aaagcagagc tccggtacca 375181 gctttcccta acactgccgt ctcatatgat tcctgctttc tttgtgcagg ttgacgcgat 375241 tccgctgacg gcaaacggaa aaaccgacag aaacgctctg ccgaagccta acgcggcaca 375301 atccggaggc aaggccttgg ccgcaccgga gacagcgctt gaagaaagtt tatgccgcat 375361 ttggcagaaa acgcttggca tagaagccat cggcattgat gacaattttt tcgatttagg 375421 cggccattca ttaaaaggga tgatgctgat tgccaacatt caggcggaat tggagaaaag 375481 cgtaccgctt aaagcactgt tcgagcagcc gacagttcgc cagctggcgg cttatatgga 375541 ggcgtctgct gtttcaggcg gccatcaagt actcaaaccg gctgacaagc aggatatgta 375601 tccattgtca tccgcacaga aacgaatgta cgtgctcaat cagcttgacc gccagacgat 375661 aagctacaac atgccatctg ttcttctaat ggaaggagag cttgatattt cgcgcctgcg 375721 cgactcactc aatcagcttg tgaaccgtca cgaatcattg cggacgtcat ttatggaagc 375781 taatggtgag cctgttcagc gcatcattga gaaggcggag gttgatcttc atgtgtttga 375841 agccaaagaa gacgaagcgg accaaaagat taaggaattt atccggccat tcgacttaaa 375901 cgacgcaccg ctcattcgcg cagctttgct tcgaatagaa gcgaaaaaac atttgctgct 375961 tttagatatg catcatatca tcgcagacgg cgtctcaaga ggcatctttg taaaagaatt 376021 ggcgctgctt tacaaaggag agcagcttcc ggagccgacg cttcattata aagatttcgc 376081 cgtttggcaa aatgaagctg agcaaaaaga acggatgaag gagcatgagg cgtactggat 376141 gtcagttctt tcaggcgagc tgccagagct tgatctcccg ctcgattatg cccgtccgcc 376201 tgtgcaaagc tttaaaggag atacgatccg tttccgtacg ggaagtgaga cggcaaaggc 376261 ggtagaaaaa ctgcttgccg aaaccggaac gaccttgcac atggtgctcc atgctgtttt 376321 ccacgtcttt ttaagcaaaa tttccggaca gcgggatatc gtcatcggct ccgttactgc 376381 cggccggacg aatgctgatg ttcaggacat gccgggaatg ttcgtcaata cacttgccct 376441 gagaatggaa gcgaaagaac agcaaacatt tgcggagctt ttggagctag caaagcagac 376501 gaacctgtca gcccttgagc atcaggagta tccgtttgaa gatctggtta atcagcttga 376561 tctccctcgg gatatgagcc gaaacccatt gtttaatgtg atggtgacga cagaaaaccc 376621 tgataaagaa cagcttacat tgcaaaatct gagcatttca ccttatgagg ctcatcaggg 376681 aacttctaag tttgatctga cactgggcgg atttactgat gaaaatggca ttggcttgca 376741 gctcgaatat gcgacagatc tgttcgcaaa agaaacagct gaaaaatgga gcgaatacgt 376801 tctgcggcta ctaaaggctg ttgcggataa cccgaaccag ccgctttcca gtctgttact 376861 ggtcaccgag acagaaaagc aagcgcttct tgaggcatgg aagggcaaag cgctgcctgt 376921 gccgacagac aaaacggttc atcagctatt cgaagagact gtccagcgcc acaaagaccg 376981 cccggctgtc acatacaacg gccaatcttg gacgtacggc gagctgaacg cgaaggcaaa 377041 ccgcctcgcc cggattctga tggactgcgg catcagcccg gatgaccgcg tcggcgttct 377101 cacgaagccg tcgcttgaaa tgtccgccgc ggtgctcggc gtcttgaaag ccggagcggc 377161 gtttgtgccg attgatcctg actacccgga tcagcggatt gagtatattt tacaggacag 377221 cggcgcgaag cttctcttga aacaggaagg catttcagtg ccggacagct atacgggaga 377281 tgtcattctt ctcgacggaa gccgcacgat tctaagcctg ccgcttgatg aaaacgacga 377341 gggaaatcca gaaaccgctg taaccgcgga gaacttggcg tacatgattt acacgtctgg 377401 aacgaccgga cagccgaagg gtgtcatggt cgagcaccat gcgcttgtga acctgtgctt 377461 ctggcaccac gacgcgttca gcatgacagc ggaggaccgc agtgcgaagt acgcgggctt 377521 cgggttcgac gcttccattt gggagatgtt cccgacctgg acgatcggcg ctgaacttca 377581 cgtcattgat gaagcgatcc gcctcgatat cgtccgcctg aacgattatt ttgaaacgaa 377641 cggcgtaacg atcacgttcc tgccgacaca gcttgcggaa cagttcatgg agcttgagaa 377701 cacatcactt cgcgtcctct tgaccggagg agacaagctg aagcgggcag tgaaaaagcc 377761 gtacacactc gtcaacaact acgggccgac agaaaatacg gtcgttgcca caagcgcaga 377821 aatccatccg gaggaaggct cgctttccat cggacgggcc attgccaata cgagagtata 377881 cattctcggc gagggcaatc aggtgcagcc ggaaggcgta gccggagagc tttgcgtggc 377941 ggggcgcgga ctggcacgag gctatctgaa tcgagaagac gaaaccgcga agcggtttgt 378001 cgctgatccg tttgtgccgg gtgaacgcat gtaccgcacc ggcgacttgg tgaagtgggt 378061 gaacggcggc atcgaataca tcggccggat cgaccagcag gtcaaggtcc gcggctaccg 378121 gatcgagctc tcagaaattg aagtccagct cgcccagctt tctgaggtgc aggatgcggc 378181 ggtgacagct gtcaaagata aaggcggcaa tacagcgatc gcggcgtatg tcacaccgga 378241 aacagctgac atagaagcac taaaatcaac actaaaggaa accctgccgg attacatgat 378301 cccggcgttc tgggtgacgc tgaacgagct tccggttacg gcaaacggca aagtcgaccg 378361 caaagccttg cctgagccgg acatcgaagc gggaagcgga gaatacaaag cgccgacgac 378421 cgacatggaa gagctgcttg ccggcatctg gcaggacgtg cttggaatgt ctgaagtcgg 378481 tgtcaccgac aatttcttct cgcttggcgg agattccatc aaaggaattc aaatggcgag 378541 ccgcttgaat cagcacggct ggaagctgga aatgaaagat ctcttccagc atccgacgat 378601 cgaagagctc acccagtacg tagagcgtgc cgaaggcaaa caggcagacc aaggcccggt 378661 ggagggcgaa gtcatcctga cgccgatcca gcgctggttc tttgaaaaga acttcacgaa 378721 caagcaccac tggaaccaat cggtgatgct tcacgccaaa aagggctttg atcctgaacg 378781 ggtggagaaa acattgcagg cgctgatcga gcatcatgac gcgctccgca tggtctaccg 378841 cgaggaaaac ggggacatcg ttcaggtgta taaaccgatc ggtgagagca aggtcagctt 378901 cgaaatcgtg gatctgtacg gctccgatga agagatgctg agaagccaga ttaagcttct 378961 cgcgaacaag ctgcaaagca gtctcgatct gcgaaacggg ccgcttttaa aggcggagca 379021 atatcgcaca gaagctgggg atcacctgct cattgctgta caccatctcg tggtcgacgg 379081 tgtgtcatgg cggattttgc ttgaagactt tgcttcaggc tacatgcagg ctgagaaaga 379141 agagagcctt gtcttcccgc aaaaaacaaa ctccttcaag gattgggcgg aagaactggc 379201 ggcattcagc caatcagcgc atcttttaca gcaggctgaa tactggtcgc aaattgccgc 379261 tgaacaggtt tctcctttac ctaaggattg tgaaacagag cagcggatcg tcaaggatac 379321 atcatctgtc ctatgtgaat taacggcaga agacactaag catcttttaa cagatgttca 379381 tcagccatat ggaactgaaa tcaacgatat tcttctcagc gcgctcggtt tgacaatgaa 379441 agaatggaca aagggggcca aaattggcat taaccttgag ggacacggcc gggaggacat 379501 tatcccgaat gtgaatatct ccagaacggt cggctggttt acggcacaat accctgttgt 379561 gctcgacata tctgacgcag atgcctcagc tgtgatcaaa acagtcaaag aaaacctgcg 379621 ccgcattccg gacaaaggtg ttggctacgg cattcttcgt tatttcacag aaacagcgga 379681 aacaaagggc ttcacaccgg agatcagctt caactatttg ggccaattcg acagtgaagt 379741 caaaaccgat ttctttgaac cgtccgcttt cgatatgggg cgccaagtaa gcggagaatc 379801 agaggcgctg tacgcattaa gcttcagcgg catgatcaga aacggccggt ttgtgctttc 379861 ctgctcctac aatgagaagg agtttgaaag agctacagtc gaggagcaaa tggaacggtt 379921 taaagaaaac ctcctgatgc taatccgcca ttgcacggaa aaagaagaca aggaattcac 379981 accaagcgac ttcagcgccg aagaccttga aatggacgag atgggagata tctttgacat 380041 gcttgaggag aatttaaaat aaaacgcaag ggaattacag aaggcgggag cgaaacatat 380101 gagtcaattt agcaaggatc aggttcaaga tatgtattac ctatcgccga tgcaggaagg 380161 gatgcttttt catgccatcc tgaatcccgg ccaaagcttt taccttgaac aaatcacgat 380221 gaaagtaaaa ggcagcttga atatcaaatg tcttgaagaa agcatgaatg tgatcatgga 380281 ccggtacgat gtatttcgta ccgtgttcat tcacgaaaaa gtaaaaaggc ctgtccaagt 380341 cgtattgaaa aaacggcagt tccatataga agaaatcgat ctgacacact taacgggcag 380401 cgagcaaaca gccaaaatca atgagtacaa agaacaggat aagatcaggg gttttgattt 380461 gacgcgggat attccgatgc gggcagccat tttcaagaaa gctgaagaaa gctttgaatg 380521 ggtgtggagc taccaccaca ttattttgga cggatggtgc ttcggcatcg tcgtacagga 380581 tctatttaag gtatacaatg ctctgcgcga acaaaagccg tacagcctgc cgcccgtcaa 380641 accgtataaa gactacatca agtggcttga aaagcaggat aaacaagcat cactgcgtta 380701 ctggcgcgaa tatttagagg gctttgaagg acaaacgacg tttgcggagc aaagaaagaa 380761 acaaaaggac ggctatgagc cgaaagagct gctcttttca ctgtcggagg cggaaacaaa 380821 ggcctttacc gagcttgcaa aatcgcagca taccactttg agtacggcgc tgcaggcagt 380881 ctggagcgta ttgatcagcc gctatcagca gtctggcgat ttggccttcg gtacagttgt 380941 ttcagggcgt cccgcggaaa tcaaaggcgt tgaacatatg gtcgggctgt ttatcaacgt 381001 tgtcccgaga cgtgtgaagc tgtctgaggg tatcacattt aacggcttgc tcaagcggct 381061 gcaggagcaa tcgctgcagt ccgagccgca tcaatatgtg ccgctttatg acatccaaag 381121 ccaggccgat cagccgaaac tgattgacca catcattgtt tttgagaact atccgcttca 381181 ggatgcgaaa aatgaagaaa gcagtgaaaa cggctttgat atggtggatg ttcatgtttt 381241 tgagaagtcg aattatgatc tcaacctgat ggcttccccg ggagatgaga tgctgattaa 381301 gcttgcctat aatgagaatg tgtttgatga ggcgtttatc ctgcgcttga aatctcagct 381361 tcttacagca attcagcagc tcatccagaa tcctgatcag cctgtcagca cgatcaacct 381421 cgttgacgac agggagagag aatttttgct aaccggctta aacccgccgg ctcaagctca 381481 tgaaacaaag cctctgacgt attggttcaa ggaagcagtg aacgccaatc cggatgcacc 381541 ggcgcttacg tattccggcc agaccctgtc ttatcgcgaa ttagatgagg aagcgaaccg 381601 cattgcacgc cggctgcaaa aacacggtgc gggcaaaggc tctgttgtag cgctgtacac 381661 gaagcgctca cttgaactgg tgatcggcat tctcggtgta ttaaaggcgg gagcagccta 381721 tctgccggtt gatccgaagc tgccagagga ccgaatctcg tatatgctgg ctgacagtgc 381781 ggcagcctgt cttctgacgc atcaggagat gaaagaacaa gcggctgagc tgccgtatac 381841 aggcacaacg ctcttcattg atgatcaaac acggtttgaa gaacaggcaa gcgatcctgc 381901 aaccgcgatt gatcctaatg atccggcata tatcatgtac acgtccggca caaccggaaa 381961 gccaaagggc aatatcacca ctcatgccaa tattcaagga ttggtcaagc atgtagacta 382021 catggcattt tctgatcagg atacgttctt gtctgtttcg aattacgcct ttgatgcatt 382081 tacctttgat ttctatgctt ctatgctgaa tgcggcacgg ctcattatcg cagatgaaca 382141 tacgctgctt gatacagaac ggctcacaga tctgatcctg caagagaatg tcaatgtcat 382201 gtttgcgaca accgcactat ttaatcttct cacagatgcg ggagaggatt ggatgaaggg 382261 gcttcgctgt atattattcg gcggagagcg cgcgtcagtg cctcatgtca gaaaagcgct 382321 gcggatcatg gggccgggca agctgattaa ctgctacggg ccgactgagg gaacagtgtt 382381 tgcgacagct cacgtcgtgc atgatctgcc ggattccatc tcctcattgc cgatcggaaa 382441 gccgatcagc aatgccagtg tttatattct gaatgagcaa agccagctcc agccattcgg 382501 ggcggtcggt gaactgtgca tcagcggaat gggcgtgtca aaagggtatg taaatcgtgc 382561 tgacctcacg aaggaaaagt ttatcgagaa cccgttcaag ccgggagaaa cgctttaccg 382621 tacaggggat ttagcgcgct ggctgccgga tggaacgatt gaatacgccg gccgtattga 382681 cgaccaggtc aaaatacgcg gacaccggat tgagcttgaa gaaatcgaaa agcagctgca 382741 ggaataccca ggtgtgaaag atgcggtcgt tgtggcggac cgccatgagt ctggcgatgc 382801 atcaatcaat gcctaccttg tgaaccgaac gcagctttca gctgaagacg tgaaggcgca 382861 cctgaaaaaa cagcttcctg cttacatggt gccgcaaacc tttaccttct tggatgagct 382921 tcctttaacg acgaacggga aagtcaataa acggctgctc ccaaaacctg atcaggatca 382981 gctggcggaa gaatggattg gaccgcggaa cgagatggaa gaaacaatcg cacaaatatg 383041 gtctgaggtt ctcggcagaa agcaaattgg cattcatgac gatttctttg cgctcggagg 383101 gcattccttg aaggccatga ccgccgcgtc ccgcatcaag aaagagctcg ggattgatct 383161 tccagtgaag cttttgtttg aagcgccgac gatcgccggc atttcagcgt atttgaaaaa 383221 cgggggctct gatggcttgc aggatgtaac gataatgaat caggatcagg agcagatcat 383281 tttcgcattt ccgccggttc tgggctatgg ccttatgtac caaaatctgt ccagccgctt 383341 gccgtcatac aagctatgcg cctttgattt tattgaggag gaagaccggc ttgaccgcta 383401 tgcggatttg atccagaagc tgcagccgga agggccttta acattgtttg gatattcagc 383461 gggatgcagc ctggcgtttg aagctgcgaa aaagcttgag gaacaaggcc gtattgttca 383521 gcggatcatc atggtggatt cctataaaaa acaaggtgtc agtgatctgg acggacgcac 383581 ggttgaaagt gatgtcgaag cgttgatgaa tgtcaatcgg gacaatgaag cgctcaacag 383641 cgaagccgtc aaacacggcc tcaagcaaaa aacacatgcc ttttactcat actacgtcaa 383701 cctgatcagc acaggccagg tgaaagcaga tattgatctg ttgacttccg gcgctgattt 383761 tgacatgccg gaatggcttg catcatggga agaagctaca acaggtgttt accgtgtgaa 383821 aagaggcttc ggaacacacg cagaaatgct gcagggcgaa acgctagata ggaatgcgga 383881 gattttgctc gaatttctta atacacaaac cgtaacggtt tcataaatga agtgatgaaa 383941 ggaggagaca gccaatgagc caactcttca aatcatttga tgcgtcggaa aaaacacagc 384001 tcatctgttt tccgtttgcc ggcggctatt cggcgtcgtt tcgccctctc catgcttttt 384061 tgcaggggga gtgcgagatg ctcgctgccg agccgccggg acacggcacg aatcaaacgt 384121 cagccattga ggatctcgaa gagctgacgg atttgtacaa gcaagaactg aaccttcgcc 384181 ctgatcggcc gtttgtgctg ttcggacaca gtatgggcgg aatgatcacc ttcaggctgg 384241 cgcaaaagct tgagcgtgaa ggcatctttc cgcaggcggt tatcatttct gcaatccagc 384301 cgcctcatat tcagcggaag aaagtgtccc acctgcctga tgatcagttt ctcgatcata 384361 ttatccaatt aggcggaatg cccgcagagc ttgttgaaaa taaggaggtc atgtcctttt 384421 tcctgccttc tttccgatca gattaccggg ctcttgaaca atttgagctt tacgatctgg 384481 cccagatcca gtcgcctgtt catgtcttta acgggcttga tgataaaaaa tgcatacgag 384541 atgcggaagg gtggaagaag tgggcaaaag acatcacatt ccatcaattt gacggcgggc 384601 acatgttcct gctgtcacaa acggaagaag tcgcagaacg gatttttgcg atcttgaatc 384661 agcatccgat cattcaaccg tgatcaaaag cggacagctt cggctgttcc gctttttttg 384721 tgttgaatgc caatttctgc atggtataat agtcgaaata ctcaaataaa ggcaggtcga 384781 aacatgcgca cgtctcccag gatgaaatgg tttgtattgc tgtttacgtt tgttttcgcc 384841 atcggaatga actcattcag aaattccttt caatttttta tgctgccaat ggcagacgcc 384901 ttccatgccg acaggtcgct gatttcggtt tctgtcagca tttttatgat cacaaccggc 384961 atcgtccagt tttttgtcgg tttttttatc gaccgtttca gtgtcagaaa aattatggcg 385021 ctgggagctg tttgcatcag cgcaagcttt ttggtgcttc cttattcacc gaatgttcat 385081 gtgttttccg ccatttacgg tgtgcttggc ggaatcgggt attcctgcgc ggtcggcgtg 385141 acgacccagt atttcatcag ctgttggttt gacacacaca aaggtctggc gcttgctatt 385201 ttgaccaatg ccaactctgc gggcctgctg cttctctcgc ccatttgggc tgcggctccg 385261 tatcatgccg gctggcagag cacctatacc attttgggaa tcgtcatggc ggctgttctg 385321 ctgccgctcc tcgtctttgg gatgaagcac ccgccacatg cgcaagcgga aactgtgaaa 385381 aaatcttatg attggcgagg gttttggaac gtgatgaagc aatcccgcct cattcatatc 385441 ctgtacttcg gcgtgtttac ttgcggattt acaatgggaa ttattgatgc tcacctcgtc 385501 ccgatactga aggatgcgca tgtctctcat gtcaacggaa tgatggccgc gttcggggca 385561 tttatcatca ttggcggatt attggcgggc tggctgtcag atctcctcgg cagcagaagc 385621 gtcatgctat ccatcttatt tttcattcgg ctgctcagcc tcatttgcct gctcattccc 385681 attctcggaa ttcatcacag cgacctttgg tacttcgggt ttatcctgtt attcgggctc 385741 agttacacag gcgtgatccc gctgaccgcg gcgtcaattt cggaaagcta tcaaacagga 385801 ttgatcggat cgctgttagg catcaatttc tttatccatc aggttgccgg agctctcagc 385861 gtgtatgcgg gcggtttgtt ttttgacatg actcatggtt atttactgat tgtcgctgtg 385921 tgcatcgtgt ttgtgggttt atcggctgta atagagctgg tgccgttttt agataaacag 385981 aaggcaaaag aaacccacca ttcaatataa aaggatcagc actgtcaatg ctgatccttt 386041 ttaaatttga gtttttttgt ttcggtattt ttaaggataa tctccttgaa tctgttcatc 386101 tcctcttcgg agtgaaaaaa atgtttgggg atcgcaatat attggccact tgatgtattg 386161 accctgaaga tatttttata ttcgaaaaca gctgtaattt catcccaatt gaaaatgagg 386221 tcatattttt tagaacatat acgaattcct tcttggttca gagtatatgt tcttttggat 386281 ttcatccgtt cgttcttctt gtatgctctg gaaaacttca catatagaag aaggaggagc 386341 agcagtgtaa acagaacgga catcacgata atcaacatac tgttcataaa caagttaagc 386401 gcgtcacttc cataaacgat acggggccat ccgttaatga agttaactgc agcaaatatg 386461 gcgcaaaaca atagaaagta aaagcatgat atttttgcga tttgataaaa aaagatttct 386521 cttacatcct taaaagtgat ttctcctgga agattgatac tttcactagc atattgaatc 386581 atacggtaaa cctacacctc taaccatgtt tttcctttta gtctagcata atttctcatt 386641 tttttgcagg cataccaggg cgctttgttt ttttctccag attgatattg ctccccacca 386701 cgccaatcat aatacaaaca gccccggcaa gatgatacca ggccaggctt tcgttgagaa 386761 tcacaaatcc tgcaatcatc gtcacaatgg tagatacatg attaaaagcg ctcattttaa 386821 acgcctcaat tcgcgacagc gtatagttag acagaaatga agtgacaagt gaagacagca 386881 cgcccaaata cacaatggcg agaacgaagc cgggctcccg gaacggcaga aaataagtgc 386941 cgactgttcc cgccgctccg tgacgcacaa gggcgatggc gttgaagacg acaaagccga 387001 tggctgacat gatgtaggtg agctcggtca gcttgaaccg ctgcgtcatt tttctggcag 387061 cagtattgta catcgctgaa gacaaagcgg acaataggat cagcaaagac ccttttaagc 387121 tggctgattc cacgtcaacg cctttcatca caaaaataaa catgacgccg gcaacggata 387181 aaaccgtgaa ccccttttgc gtccacgttg ggcgttcctt taaaacataa gcggcaaaga 387241 ccatcgtgaa aatcggaatg gctgcctgaa taattcccgc ttcagaggag gacgagtaca 387301 caaggccgaa tgcctgaaag ctgaaaaata acgcgggata cagcagggcg agcggcaaaa 387361 tgtcaatgac gtcctttacg cggattgata gctttaccca gccgaataag atcggtacag 387421 tggccgcagc aaacgcaatg gtgaaccgat gcgccaaaat atcaaacggc tctgctgttt 387481 gcagtgcgat ttttacgaat agaaaggata aaccgataat gaacgaatat aaaatagccg 387541 ctatataagc gggggtttgc tgatgtttaa ccataatggg aagggctcct ttacctgaat 387601 tgcagcgccg gtcgctccct ttattgtatg gccgcggtca gaacggtaca atgagaaaaa 387661 caatgaactg taccggtaca aaacaggggg agaaggcatg gagaaatata tgagtctatt 387721 aacgaggata gaggagatga tgcaaagcac ctcatatcaa gaaggagaca ggcttccatc 387781 tatccgtcag ctgtccgccc gctaccaagt cagcaaaagc acagtgatcc gcgcgctgca 387841 ggagctggaa aagcgccacc ttatctattc tgttccgaaa agcggctatt atattgtgaa 387901 aaagtcaggg aaatcaaaaa gcgggcagcc tggccccatc gactttgcca catctgcgcc 387961 ggatcccgat gtgtttccgt atcttgattt tcagcactgc atcaacaaag cgattgatac 388021 atacaaaaac gatttgttta tttatgggac gccaaagggg cttccatcac tcatccgcgt 388081 actccgaaag ctcttggcca ctcaacaggt atttgcggat gaacggcata ttttcattac 388141 atcaggtgtc cagcaggcgt tatccttgct ttgtgccatg ccgttcccaa atgggaaaga 388201 gaagatcgcc attgaacagc cgggctacca tttgatggtc gaacagcttg agacacttgg 388261 gattcccgcc atcggggtga aacgaacgga agaagggctt gatatagcca aggttgagcg 388321 gttatttcaa acagaatcga ttaaattttt ttatacgatg ccgcgcttcc ataacccgct 388381 tgggtgctca ttgtcagagc gtgataaaca ggagcttgtg agactggcag aagcgtatga 388441 tgtctatctc gttgaggatg attacctcgg tgatctggag gaaaataaaa aggcagatcc 388501 gctgtacgca tatgatctgt cctcacatgt catctatttg aaaagcttct cgaaaatgat 388561 gttccccggc ctccgcgtgg gggcggctgt tttgcccgaa gcgctgactg acacgttcta 388621 tgcgtacaaa aagctgaacg acatcgactg ttcgatgatt tctcaagcgg cattggagat 388681 ttacctgaaa agcggtatgt acggcaggca taaggagaaa atcagagatt cttataaaga 388741 gcggtcgctg aggctacatc aagccattcg aactcacagg cagctgggaa gcggacgctt 388801 tacgttctcc agcgggcagg caccctgtat gcacacccat ctggtgcttc ctcaggatct 388861 gcccgcctca agagtgattc atagactgga aaaacaaggg gttctccttg aggcgataga 388921 ccgtcattat ttatcagatt atccgaaaga aaatctatta aaaatcaata tttccaatgt 388981 gaaaacggaa gatattgagc gcggtgtcaa gctgttgatg agccatttat aaaagctctt 389041 cgtacgagac cattgtgata tcctcgggga aatcagggtg tacggcgcat acagccattt 389101 tgtagccggg atcgacctca tacgttttga tatagcatgg ggaatggctg tccggaagct 389161 caatggatac ttgtccgtcc tggtgcaggc gcactgaaaa ggaatcaagc ggaagcgata 389221 agcctttgcc ttccttgttt gataaagctt tctttcattg accatagatg ataaaaatag 389281 tctgtctgct cgtccttgtc ttttgctaaa aggtcgctgt actctgtttt tgaaaagaag 389341 cgcttggcga tctcaaggct gatcggtttc gttttttcga tatctatgcc gatcggctgt 389401 gaatcaaacg cgcaaatgac ccagcgtccg gagtgagaaa tgttgaaatg agcgtcggga 389461 agatcaggga tgcacggctt cccgtattcc tgcgtgctaa agcggatatc ggatttgtcc 389521 aactgatact gcctgcttat gactgagcga acgagcacat ctcccagcag ggtgcggtga 389581 gcatcttctt tatgataaaa tctccggcat ttctcccgtt tttcaggtga tatgaaagac 389641 atgaaccgtt cattttcttc ctgtgaaagc gggcggtcca tataaattcc gtaaatcttc 389701 attctagatc ctccgtctgc aaaagattgt caaaaccatc ctatcatact tccacaagac 389761 tcatatagag gagaaaataa aaaaacaaag ccaaggcggc tttgttttag tgtacaggcg 389821 gagatgcttt cactgcggct gtccgccttg ccacagcata attcagcaac tggattgact 389881 ggggcaatga aaaacgcaaa ataagtccgg tgaggatggc ggtcaaaatg gtgccaaaac 389941 cgatcggtcc gcccatgccc catgccgcaa acaaaatggt taattccatg ccgttccgca 390001 cccattgcac attccagccg gttttttctg taatcagcat catcagtgaa tcacgcggcc 390061 ccgcgccaag gcctgctgat acataaacac cgacgccgta accaatcagc accacgccta 390121 gagagaagac gatgatcgag cctgtgtagg tcgagagggc aggcagaatg aaattgaaaa 390181 aatctataaa tacaccaatg agcaccatat tcaggagggc accaattttc ggccaagctc 390241 tcgtaaacaa tgacgtgaat ccgacgatga gcgctccaat aatgatggac cactggccga 390301 cggtaagccc gaagtgctga aacaggctgt aatgaaatgc atcccacgga ctaatgccga 390361 gtgcttttcc ttctatcgtc agggatacac caaaagccaa aatgatcaaa ccggcaaaat 390421 aaaatgtcca gcgcagaaca agttcttgct tcacgtgagg tcccttcttt cgtaaaaatc 390481 agtcgattgt cattgtagca catctgacag aagggcggaa taggcgaaag gggctcaaca 390541 aaaaaacagg gccgccggag gcgccctgtt tcagcgtgtt ggcaaaccct tgcattcgtt 390601 gtcaggcctg tgcttcggtg ctcacgaatt taacattagc tgtgctccaa tgctcgccct 390661 tcctagactt caaaggtttt caatcacgct gaaaatcaca aaatcctaaa acgaatatcg 390721 ttttaggatt ttgtcaataa tctgaaacag ggcgctgacg ctctgttttt cttattacag 390781 cgggttcaaa atccggttta agaaccgctg tgtccgttct tcttttggtg cggagaaaat 390841 ttgctccggc ggtccctgct ccacgataac gccgccgtcg atgaagatga cttcatccgc 390901 aacctcctgc gcgaacttga tttcgtgggt cacgacgacc atggtccagc cttcattggc 390961 caagtccttg ataaccttca gcacctctcc gacaagctcg ggatcaagcg ctgaggtcgg 391021 ttcgtcaaac agcatgagct caggctgtat cgccagtgcg cgggcgatgc cgacgcgctg 391081 ctgctggccg ccggaaagct ggaacggata taaatccatt ttgtccttca atccgacttt 391141 atcaagaagc tgaatcgctt cttttctgac ttcctctttg ttccgttttt gcacctgaac 391201 agggccctcc atcacgtttt cgagggctgt gcggtgcggg aacaggtgat acgcctgaaa 391261 caccattccg gattttcggc gaagctttag gatatccgcc tgtttcacct ttttggagaa 391321 atcgatggag aaatcatcaa atgcaagctc tccgcgattc gggatctcca gagcgttcag 391381 gcagcggagc agcgtcgttt tccctgaacc tgaaggccca agtatggcga tgacttttcc 391441 tttttcaatc ttcatatcta tcttttttaa aatttcattt tcaccgaatg atttgtttaa 391501 tcctttaacg gtaagcatac tcggaacctc cttatttggc cacgtagcgg tcaagacgcc 391561 gttcgatgac atgctggacg agtgagagca ggaagcagat aatccaataa ataaaggctg 391621 cttcaatata gatcactaaa atttgatcaa gattccgcgc gccgatttcc tgggcttttc 391681 tgaacagctc agcgaccaga atttgagagg cgagggatgt atctttaatc aggctgataa 391741 aggtattgga taatggcggg atcgacacac gaaacgcctg cggcaaaatg acgcggaaca 391801 gcgttttttg atgtgtcatg ccaattgtgt agccggcttc ccattgccct ttcggcacgg 391861 ataaaataga tgcccgaatg atttcagatg cataggcgcc gacgtttaat gaaaaggcga 391921 taactgcgct tggaaatgga tctaatgtga cgttaaaggc cgggaacaga tagaaaatga 391981 tgaacaattg aacgagaaga ggagtgccgc gtattgcgga tacgtatacg ctgaacaccc 392041 atctcaaagg tctcactttc gacattctgg caagcgccgt aatcagcgcc aggatcattc 392101 cgaatataaa ggaaagaatc gtaaggggaa tcgtatagta gattccccct gaaagtatcg 392161 gccagaatga ctgctgcacc agatcccacg ggatcgccgt gccaagcgtc aatgccggca 392221 gattatttag aaacatcttc gccgaaccat tttttagaaa ttttagaaag agtcccgtcc 392281 tctttcattt cttttaatgc tttgttgact tgatcaacaa cctcgccgct tcctttacgg 392341 aacgtgaaat atgttgactg aggctcacct gtttcaaacg cgattttcac gtttttattg 392401 ccagatgttt ttaagtagtt caatacggca agcttatcgt tgtatgtcat atcgacgcgg 392461 ccttgctgga tcatttgaag ggcctgcgcc atgccttcaa cgccttctac tttagcgccg 392521 gcatttgtag ctaatttgtt gtagttgctt gtcagtgatt gagctgacgt ttttcctttt 392581 acatctgctt cagacttaat atcgttgttg tcttttttcg ttacgacaac ggctcttgat 392641 gttgtgtatt tatctgagaa atcatatttg tcttcacgat ctgtttttcc gacttggttg 392701 gcaacaacgt caaaccgttt ggaattcagg ccggcaaaca tactgtccca ttgtgtttcc 392761 ttaaagtcga ctttaagccc gaggcgtttt gcgacttctg tgataacttc gacatcatag 392821 ccagtcagtt tatcagtgtc tttgtcgtgg taagtgaacg gctcatatgt tccttccgtt 392881 ccgactgtga gcacaccttt tttcttaatt gaagcccaaa gatcgccatc tttggcatta 392941 tcttttgact gattgtcatt tcctgctccg caagctgcaa gagctgcaat acttacgacc 393001 atgaataaag ccaataatgc ttttttcatc ttattcccca cttttctggt tgattttatt 393061 gaaataaaaa attagcttac aaatctaaag gataactttt ttttagtatg agtcaagtat 393121 ttggttttca taagacaaaa tcttttaaaa taaatccaaa aattgctgtg ccggtttagg 393181 caaataactg tccgttctcc acatgacagc cggtgtcata atgaagggat tattttcgat 393241 atggacggtg tgaacgtgat ttctcatatg aacgggaatc attgtgacag gcaaaataga 393301 cgcgccgaat ccggatgaca cgaggctgag caaagttgca gagtcgtggc attcacaaac 393361 aatgcgcggc tccaggttca aacgatgaaa ttcattcatg acctgattat agacgccttt 393421 tccgttgaca ggccgcagca ggatcagcgg aaatgaagga atgtccacca tcttaatggt 393481 gtctccgcac ggatatccgg cttcatctga aagcacgagc acacatggaa tgtcatcaag 393541 ctgcttgaat tgtactgtgt cacttttgat cagtgttgtc gtgaccgccg catcgatttg 393601 ccggctttcc agcagttcca acagtgtcgc gggttcattt tcccaaatat taaaggtgag 393661 atgggggtat ctctctttga tctgtgttac tttttcaagc atcagagccg cgcaataaat 393721 cgttgatccc acggcaagtg taccggctac ttcctccttc agctcctgta cctcaatgac 393781 tgcatcttca aacctatgca gaatctcttt tgctcttttt agaaaaacag ctccttcata 393841 tgtaagagtc atttgttttt tcttgttacg gtcaaacaga acaacaccaa gttcgtcctc 393901 cagctgtttg agctgcctgc ttaaaggcgg ctgcgccatg tgaagctttt tggctgcgga 393961 cgtaattttc tgttcttggg caatggtaat gaagtatcga agctggcgaa tatccaaaag 394021 aaagcgcctc cttatcatac cttttaggta ttaattatag atttaataga tatttttcat 394081 atggatatat caggagtatg attgaaatga aagcagaatt caagcgtaaa ggagggggca 394141 aagtgaaact cgttgtcgga atgacagggg caacaggggc cattttcggg gtcaggctgc 394201 tgcagtggct gaaggccgcc ggagtggaaa cccatctcgt tgtgtctcct tgggcaaacg 394261 tcacgatcaa acacgaaaca ggctatacgt tacaagaagt agaacaactg gccacataca 394321 cttactcaca taaggatcag gcggcagcca tttcaagcgg gtcgtttgat accgatggaa 394381 tgattgttgc gccgtgcagc atgaaatctc tcgcaagcat tcgcacagga atggcggata 394441 atctgctgac acgtgcggcg gatgtcatgc tcaaggagag aaaaaaactc gtcctcttaa 394501 cgagagagac gcctttgaac caaattcatc tcgaaaatat gctagcgctt acgaaaatgg 394561 gcaccatcat tcttcctccg atgccggcat tttataatcg gccgagaagc ttagaggaaa 394621 tggttgacca tattgttttt agaacgttgg accaattcgg cattcggctt cctgaagcga 394681 agcgctggaa tgggattgaa aaacaaaaag gaggagcttg atcatggctt atcaagattt 394741 cagagaattt ctcgctgccc ttgaaaaaga aggacagctg cttacagtga atgaagaggt 394801 aaagccggaa ccggatttag gggcctccgc acgggcagcc agcaatcttg gcgataaaag 394861 ccctgcgctc ttatttaaca acatttacgg ctatcataac gcgcgaattg cgatgaatgt 394921 catcggctct tggccaaacc atgccatgat gctgggcatg ccgaaagaca caccggtaaa 394981 agaacagttt tttgaattcg caaagcgtta tgaccagttt ccgatgccgg tcaaacgtga 395041 ggaaacagcg ccatttcatg aaaatgaaat cacagaagat atcaatttgt tcgatatact 395101 gcctcttttc agaattaacc agggtgatgg aggctactat ttagacaaag catgtgtcat 395161 ttcccgtgat cttgaggacc ctgacaactt cggcaaacaa aatgtcggca tttacagaat 395221 gcaagtcaaa ggaaaagacc gccttggcat tcagcctgtc ccgcagcacg atattgcaat 395281 ccatctgcgc caagctgaag aacgcggcat caaccttccg gtcactattg cgctcggctg 395341 tgagccggtc attacaacgg cggcatcgac tccgcttctc tatgatcaat cagaatacga 395401 aatggcaggt gcgattcaag gcgaaccata tcgcatcgtc aaatcaaagc tgtctgatct 395461 tgatgttccg tggggcgctg aagtggtgct tgaaggtgag attattgccg gagagcgcga 395521 atatgaaggg ccgttcggtg aattcacagg ccattattcc ggcggacgca gcatgccgat 395581 tatcaaaatt aaacgcgtct atcacagaaa caatccgatc tttgaacatt tatacttagg 395641 catgccttgg acagaatgcg attacatgat cggcattaac acatgcgtgc cgctttatca 395701 gcagttaaaa gaagcgtatc cgaacgaaat tgtggcagtg aacgccatgt acacacacgg 395761 tttaatcgcg attgtttcca caaaaacccg ctatggcgga tttgcgaaag cggtcggcat 395821 gcgcgcactc acaacgccgc acggactcgg ctactgcaaa atggtcatag tcgttgatga 395881 ggatgtcgat ccattcaacc ttccgcaggt catgtgggcg ctttcgacca aaatgcatcc 395941 gaaacatgat gcggtcatca ttccggactt atctgtcctg ccgcttgatc cgggatccaa 396001 tccatcagga atcactcaca aaatgattct cgacgccact acaccggttg cgccggaaac 396061 aagaggccat tattcacagc cgcttgattc tccgctaaca acgaaagaat gggaacaaaa 396121 actaatggac ttaatgaata aataaggaaa ggatgttcga aatgcataca tgtcctcgat 396181 gcgactcaaa aaagggagaa gtcatgagca aatcgcctgt agaaggcgca tgggaagttt 396241 atcagtgcca aacatgcttt tttacatgga gatcctgtga accggaaagc attacaaatc 396301 ccgaaaaata caatccagcg tttaaaattg atccaaagga aacagaaaca gcaattgaag 396361 ttccggcggt gccggaacga aaggcttgat ccgcgtgaac tgtatgtcag accgtctctt 396421 tgagctgctt gacgggagct gcctgaatga gaagcagcat gaggccttcg ttctgcaaac 396481 agtatcagag gatggctggc cgcatgccgc tatgatcagt gcaggtgaaa tcatcgcgct 396541 gagccgaact gatatccgaa tcgctctgtg gaaaaacaca atgacttcgg ccaacatcct 396601 tcgcacagga aaagcacagt tcacggcgtg gtggaaggga gcggcctatt atgtaaagct 396661 tgaatgcgcg cctttaccgc ctttgaaaga tgccgaatat gaaagagacc gtttttcctg 396721 ccgcatcgtt tcagtgaaag aggacgttgc gaaatacgct gatttgactt caggtgtccg 396781 tatacagctt cacagccctg aagaggtgct gagcagatgg aaaaagaccc tggaagattt 396841 aaaacggtaa tatcgatagc ctgacgccat gcgtcaggct ttttttatat aatgaaaaca 396901 aaagggggcg tgagaaatgg aacgtgcggg gatctgtcac tcggacggct ttgatttagc 396961 ttatcgaatt gagggcgagg gcgcacccat ccttgtgatc gggagtgcgg tttactatcc 397021 gcgccttttt tcctcagata tcaaacagaa atatcaatgg gtctttgtcg accatagggg 397081 atttgctaag cctaagcggg agcttcgtgc ggaggattcg aggcttgatg ctgtcttggc 397141 tgatatcgaa aggatgagaa catttcttca gcttgaggat gttactatcc tgggacattc 397201 cgggcacgct tttatggctt tagagtatgc caggacatat cccaaacaag ttcggaaggt 397261 ggcgctcttt aatactgcgc ctgataacag tgaagaaaga cagcgaaaaa gcgaatcatt 397321 tttcatggaa acagccagtc ttgagagaaa gaaacgcttt gaaaaagaca tcgagaattt 397381 gccgcaggac atcgacaaag atcctgaaag gcgctttgtg cacatgtgta ttcgcgctga 397441 agcgaaaagc ttttatcaag agcggccgca tgctgctgcc ttatgggacg gtgtattcac 397501 gaatatgccg atcattgatg aattatgggg caatacattt gcccggattg atcttcttca 397561 gcggttagct gatgttcgta tgccggtgta tatcggatta gggagatatg attatttggt 397621 tgcgcccgtt tcgctatggg atgctgttga cggtttatat ccccatgttg ataaggttat 397681 ttttgaaaag agcggccatc agccgatgct ggaagaaccg gaagcctttg atcaaagctt 397741 caggaaatgg cttgatcaat aaaaaacagc ccgcagatca acatccgcgg gctgtttctg 397801 attataagac ccctttcatc gcgcgtttga tcaccggcga gagcagcagg agaatgccgc 397861 caagaacgat agaaatcaaa ccgatggtgc cgaagtacat tgtttcagga attttatcaa 397921 acaatccggc tacttgggca ttgatcgctt gggctgctgc gttcgtcaga aaccacatac 397981 tcattgtctg tgcagagaag gcagctggtg ccagtttcgt tgtcacggat aaaccgactg 398041 gagacaggca cagctctcca agcacgacaa gcaggaagct gagaacgagc caaagcgggc 398101 ttacgagtgc ttcttttcct tgcatagcag ggaataccat aatgataaat gacaatccgg 398161 ctaaaataat tccgattgag aatttaactg gtgtagacgg ctgacgtttg ccaagcttca 398221 tccagagcca tgcgaatatt ggcgcaaaaa tgacaacaaa caatggattt aatgattgga 398281 accatgatga ctgaagttcg aatccgccca atgaaagtct tatgcgttca tcagcgtata 398341 ccgcaagaat ggtcgctccc tgttcctgaa tggcccagaa catgacagca ccgataaaca 398401 aaggaacgta agcggcaaga cgggattttt ctgttttgtc cgcttttttg cttgtaaaca 398461 tgatgatgaa ataaatcaca ggaatcaaaa taccgagaat acttacaagg tcaatgaaac 398521 gtttgatcgt cagcacgcct gtttgtacag agataatcac tgcgatcgcc acaatgataa 398581 caccgattcc ggtgccaatt gcagattttt tagacagcgg attcggcaca ttggaacctg 398641 caagcccgag gtttttcttt cttgtcaaag caaatacgat aagtccgaga agcattccga 398701 ccgcggcagc tccgaatccg agatgatagt tgtacttctg tccgagtgtt ccgacaatta 398761 acggcgcgag taaaccaccg aggttaatcc ccatgtagaa aatactgaaa cctgagtcgc 398821 ggcgcgggtc ttctttcgtg taaagatccc caactacgct tgaaacgttt ggttttaata 398881 agcctgttcc gacaatgata agcaccatac tgatatagaa tgctatcgaa ctgcccggat 398941 aggcgagtgc aatgtggccg aacataatga atatgccgcc gtaaaacacg gtgtttgcgg 399001 taccgaatac ccggtcagcg agccatccgc caataatggt ggacatgtat acgagtgatc 399061 cgtaaatcga cataatggca accgcagtgc ccttgtcaaa gccgagccct ccgtttaccg 399121 tctctgtata caaatagtaa agtaagattg ctctcattcc atagtaagag aaacgctccc 399181 aaaattcggt gaaaaatagt gtaaatagtc ctcgcgggtg accaaagaac cctttttgcg 399241 ggacgctttt aatgatactt tcgttatcaa tcgaagccat gtcagccaaa ccctttctaa 399301 aaaaagtgta ttataaaaat catattctta tataatactt gtgtcaatat aatttatact 399361 catttcaaat agttccatat tggaaaaatt ataaatacct aaaaatagtg atttcctcct 399421 aatttttaaa ctttttatcg tgagattttc ttacacaact attcctttat atttttttaa 399481 taaaatttta gagaaatgta caagcagatc gggcctttgt gagtaacatg atagtaatca 399541 tagagaagga ggctcgcaat tggctgaatt catattaaat gcagcggatt tcggtgttcc 399601 tagagatggt aaaacggatt cgacagaacg gattaatcag tgcctcagta cagctgtttc 399661 gaaaggctat catactgtct ggtttccaaa gggaacatat ttaatagacg caacgcttgg 399721 cggagatctt aatcagaggt ttcgaaacgc ggggatcatt gttcccggca accttgagat 399781 tatgatggac cccgaatgta tcatgaaagt gataccgaat agttcgtggg gttattccgc 399841 attttatgta ggcaagcaag agaatataac tatttccgga ggacaaatta tcggcgaacg 399901 ggatgagcat acgtatgcct cggcggggat aaggtcaacc catgaatggg gctttggcat 399961 atgtattgaa ggatgctcga atgttgtcat tgatgatgtg aaaatttccg attttaccgg 400021 cgatgggatc atagtcagcc caaggggatt aaagaccaat caagattatc gaacgtcaga 400081 gcaaattatc atccgccgct gtgaggttcg gcggtcgagg agaaataaca tttccattac 400141 cggatgtgac atggtcacgg tggaggaatg cttgattgaa gatgccggaa cggggaatgg 400201 aacagcgccg aaattcggaa ttgacattga aggatatggc gaaggtgacg ttgattatga 400261 ggaaccgatt aatgtatcaa ttcgcaataa ccactttgtt ggaaacgttt caagttctgt 400321 gaccaatttt aacgggtatg gcattttaat agaaggaaat cactcagaca atacaatcag 400381 ctacggatat gggacgcaaa cagtgatcaa gggcaatatt ctgagacgcc ctgaagacgc 400441 ggcggctgcg ccaagagtcg ggataaccgg actcggtgta tcacaaggaa aagagaccag 400501 tgatgcagtg atcgctggca acctcattac cggattttca actggaattg atgtcagggg 400561 aaagagcgtt cttgtgacga acaacaaaat cagcaacttt gaaaacacag ggatattggt 400621 ttatcagtcc tccgacgtaa aggtagacgg aaaccaaatt caaaacggac tgtctgaaac 400681 aaggcgcagc atcggtcttc gcgcagtgct gtcagatgac atcgcatttc tgaataactg 400741 tctcattcaa gtcgttgacg gtgtgaacgt ttccggcgga aatatgatca ttaaagataa 400801 tctcctgaga aaattcagcc ggggcatttg gattgctcaa gggaacgcgg tgattgaagg 400861 gaatacactg aatcctgacg cgtttgaagc agtgccggaa tcatattctg tttccgtcac 400921 aaacaatgcc ggcgccatca tcaaaaacaa tacatttaaa gagttcaaaa attaccccat 400981 ttattgctcc acaagtgcaa aaacctcaat tatcggcaac cacttagagc gatccccgct 401041 tttggtcacc atctatatca gcgcaggtgt gcatgagatt tttgataata ccatttcagt 401101 caacagaaca gccgggaatc cgattgtgat ttatctcaat ggctctgcag gctctatcat 401161 ctctggaaac accatcaata acctctccgc gggcactgcg acagctattc aaacaaacac 401221 gtcaaccaat tccaaaatca tcggcaaccg catttttaaa gggaccatca acaaacacag 401281 cagtgataca atagacggca atatgattgt ctgaaaaaag cgcccccctt taggggttct 401341 tttttttcga tttatagatc acgtacattt ctctcacaag tactaacaca aaaaataaaa 401401 gcacgaccca ttccgcaaat gttgtcatct taaagctgga catattgtta taaacggctt 401461 ttgttaaact gaacccttga agcatgtcca tcaacacaga aatagctaat aaacaaatta 401521 atatgaatcc ggtcacgccc aatatcttca tgcttcatca tcctccgctt ttagtgtcta 401581 tctttggcgg agaagttata ccgcatctaa ccctaatgca taatctcaat tttaaaagga 401641 agaatatgag aaaacgacaa ggaaaggtat ttgtgtatgc ctttattttc taagcgaaag 401701 aacaataccg attcaaaaga caagcagaat acagacgaaa ggaatcagga acagcagcaa 401761 gaaaaagaaa ggccggttct catttctcca agtttagcaa agaatatagc ggaaacgaaa 401821 aaggaagtcg gaagcagctc tgacgtcatc attcgcgaga ttaaaatcgg ggagcaggat 401881 catgtccacc tagctgttat ctatatttct gggctggtcg ataataacac gatccatgag 401941 tcgttaattg acccattggt acaggatgag tctatccaga atactcatgc gatccagcaa 402001 attcttgaaa aaacgctccc gctgggcggg gtgaaagcgg aaaagagctg ggacaagctt 402061 ttttccgagt taatgcttgg caatgcgctc atttttgctg atggccatga tgaagctttg 402121 atttgcagca ctcaaggggg agagcagcgc tccatccaag agccgagcac ccaggtgtca 402181 ttccgcggcc cgcgccaagg gtttacagag tctctgcaaa ccaatatttc catgatccgg 402241 cgatacatta aaaatccgaa tttatgggtt gaaaaaatga aaaaaggttc tgttacgaat 402301 acggatatcg ctctcatgta cattcaagga atatgtgatg aaaaggtgct gaaggaagtg 402361 aaacagcgcc tggaaaaaat agatattgac agtattttgg aatctggata tattgagcag 402421 ctgattgaag atgaaacctt tacgacgttt ccgactatgt atcatacaga acgccctgat 402481 gttgtagcgg gtaatctgtt agaaggaaga ttcgcgatta ttgtggacgg aacaccgttt 402541 gtgcttattg ccccagcctt atttgtccag ttttttcagt ctgttgagga ttattattcg 402601 cgttttgaca ttgcgacaag cataagaatt cttcgtgttt tagtcttttt catttcgctt 402661 gtggcaccag ctgtatacgt ggcagccacg acgtttcatc aagaaatgat accgactcag 402721 ctgttagtgg tcattgcggc ccagcgggaa attgtcccgt ttccggctgt tgtggaggcg 402781 ctgacgatgg aggttgcttt tgagattctg agggaagcgg gagtcaggct gccccgggtt 402841 gtcggctcgg cagtgtcaat cgtaggcgcg ctcgtaatcg gccaggctgc cgtacaggct 402901 ggtatcgtct ctccggcaat ggtgattatc gtggcactca ccgcgattgc gagcttcgca 402961 acaccggcgt ttgcaatggc gatttcagcc cggcttattc ggtttatctt tattattgcc 403021 tcagctgtta tgggttttta cgggctgatt ttagggatca ttatgatgtt tgtccactta 403081 tgcagtcttc gttcattcgg cgttccatat atgtcgccgc ttgcaccttt ttcttcacaa 403141 ggcgtaaagg acgcgctttt ccgggttccg tggtgggccg atgaaaaaag gccggaatcg 403201 gtcagcaagg aagataaggt gcggcagggg aaagatcaac gcccagagcc ggccgcttca 403261 cgaggaatgg tgaacaaaga tttggaagaa ggggatcaga atggtacgta aatgtctatt 403321 agccgttctc atgcttttga gcgtcattgt gctgcccggc tgctgggata agcgggagct 403381 gacggatctt gcgattatct cggcgattgg catcgatcgg acaaacgaca gcaactacgt 403441 gctgcatctt caaattatca atccaggaaa tgttgccggc ggccttcagg gaggcggtgc 403501 tggagacagg ccgcctgtat ctgtctattc gattgaaggt aacaatataa cggaagcact 403561 cagaaaagcc tccatgaagg tatcacggcg gctttatttt gcccatacca atctagtcgt 403621 gatcaatgaa aagctggcaa aagaagaagg tttggatttt gtattagata atcttgaccg 403681 ggacacagaa ttcaggacaa cagcaacatt cgtcgttgcc cataaaacaa aagcagaaaa 403741 tattgtgaaa atcttgacgc cgattgataa aattccgtca aataaagtca ataaaacact 403801 cgatttcacg gaggcacaat acgggcgggt ggtcaaaatc aatattcagg acgttttgaa 403861 aacacttgcc gccaacacta tggcaccggt catccccgga tatatgatga ttggtgacga 403921 taaaaaagga gtcagcatgg aaaacacgca ggcgactgac ccgaaagcca ttcttcaggc 403981 agatggtttg gcggtttttg ataaggcagg atatttaaag tattggctgg aagatgatga 404041 aagcgtgggg gcagtctggc ttatgaataa gatccagcat acgtttatta atgctgactg 404101 gggcaagacg aaggatgcgg tcagcttgca ggttacccat caagatacaa agctggtacc 404161 gaaaatgcgg aacggacgcc cgtacatcca tgtgaaagtg tcggttgaag gtattataga 404221 tgctgtcaaa taccctttcc aattgtctga tcccaaggtg ctggccgcta ttgaaaaagc 404281 gctcaacaaa gagcttgaaa aggaaatcag ccatactgtg aaaaagatta agaagaataa 404341 aatagatttt atcggttttg gtgacacgat atatagaaag tatccggagc agtgggagaa 404401 aatgaaggac acttgggaca aagaatattt gccggaactg cccatcgatg tgaaggccga 404461 gacgtatatc agaaggacgg gattgcgaaa caatccgatc aaacaccagt ttaaagatga 404521 ttaggtctga agaaagggga agtgacagat ggaaaaagcc agaataagca taaggcagtt 404581 gtttgtcatg attatcattt ttgaactggg cagctcctta ttgattacac cgggatcaat 404641 ggcgggcagg gatgcttgga tagcagtttt attaggctgt gcgatcggac tgtttctttt 404701 ctatttgtat caaggcattt atcaatgtta tccgaattct tctccgaaag aatatatgga 404761 tgatatgctg ggaaccaagc tgagctggct gttttcattt ctctatatct tgtactttgc 404821 ctatattgcc gcaagggtgc tgcgtgactt tggagaaatg ctgctgacgt ttgcttatca 404881 tgatacacct atcattattg taaatgcttt attaatggta gtaagcatat atgccgtaag 404941 aaaaggaatt gaagtactcg cacgcgcggc cgaacttctt ttcggggcca tgtatttact 405001 gggcgcgatc ggccttgtgc tgattattgt ctcagggact atagacccgc acaatttaaa 405061 gccggttttg gcaaacggca tttctcctgt ccttcactct gttttcacac agaccatgta 405121 cgttccattt ggtgaagttg ttttatttgt gatgattttc cctaacctga atgacagaaa 405181 agatgtgaaa aaaatgggga tgatcgccat ggctattagc ggattgattg tggcgctcac 405241 cgtggcgatt aatattagcg tgcttgatgt tgatcttaca ctcagatccc agtttccgct 405301 tttaagcacg atccagacaa tcaaggtcga agaattttta gaccggctcg atgtcttttt 405361 tatgctggcg ctgatcatcg gcggcttctt taaggtcagc ctctacttat atgccactgt 405421 ggttgggaca tctacgctct ttaaggaaaa gaacccctct caattggctt atccgatggg 405481 attgggcatc ttaatccttt ctataacgat cgcgactaac ttttcggagc acttgaatga 405541 aggcctgaac gtggtgccgc tgtatattca tttgcctttt caattattgt ttccgctctt 405601 tctgtttatt gtggccgttt ggaaaaagaa acgaagagag aagtcaaaag gggaggaagc 405661 aaaaaaatga taaaaagagc ggggggatgc ggccgccgct ctttttatgt tcacttctat 405721 ataaaagggg gatatagggt gcgcccctgt ctgcactggc agaggcgcgt tttgttatac 405781 gactgcgacg ttttccttca cagtaaaact tcctcttgaa agtctgatat tgatgtctga 405841 cacttttgca atttgttcat cgtgcgtcac cataatgacg catttatctt ccttgtgcgc 405901 cagatcctga aagagccgta cgatctcttt tgatgtgtcc tcatcaaggt ttccggtcgg 405961 ttcatcggct acgataagat ccgtgtcaca gcagaaagcc cttgtaattg atacccgctg 406021 ctgctgtccg ccgctcagtg tgagcacttt ttgccgggct tgtttttcgt tgatgccaac 406081 cttctgcagc atgtcaagcg catatgattc tttgttcttt tctttagaac ctgtgatttc 406141 catagcggtt gtgacgttct gcaaagccgt catatacggg agcaggttgt acgcctgaaa 406201 gacgattgat acatattgat ttctgaaatt ggttaagccg attttagaaa ccgcttttcc 406261 gtcgtaaagg atgtttcctt cttttggtgc gtcaagtccg cctgccagag acaggaaagt 406321 ggttttcccc gtccctgatg ttccgacgat tgtgtagaat tttccttttt gaaagctgat 406381 gttaatatcc tgaaacaatg gctggctttt gtttttatac cagtagccga cttgttgaaa 406441 ttgtaataag ctcataggtt ccgcctcttt ctattcctgt tttgtcaata tcgttttcgg 406501 atgaagccgc agtactgaaa ttgacggcag caatgttgca atgattgcga ttaggatgcc 406561 gatcccgcca agtataagca tgtcgttcat agaaaccgcg acgttcagtg aatcgataac 406621 gtccacgttg gatgaactgt ggccgaacat tttgccgccc atgccgccac cgccgccggg 406681 catttgtccg cttgcggttt gcgttgaatc ggttgatgaa ctgatttgct gggataaaag 406741 ctgatttcca agctgattcg cgacgagatt tcccgtcaca gatgcaaggc cgatagcgat 406801 aacggccaca atcagaatct cagtcaagaa ctgtccaatc aatttccatc gtttttcacc 406861 gatggccatt aacacgccca tttcgtattt gcgctccctg attgacatca tgacaatcag 406921 gccaagaatg acggcgcctg ccactgatac aagatacacc acgtttttag agaaagaagc 406981 cacattttca atcggtccga ccatttgctg gtaaagctga tcgtttgtat tcagtgtgta 407041 cgtatcaaag tcaattgatg ttttcttcgc tgcttttacg aaagtatcca tatttttcgc 407101 gtcgtccata tagtaaacag ctgagtcaat cgtattttta tagtcgtcgc ctttcaatgc 407161 cgctgttgct gtgtaaggcg tataaagctt gttataagga tttaagaaag agaaattttg 407221 ggcttggtca tcacctgaag atgttgtttt ataaataccg acgatcttca gttttactgt 407281 tgtatcctca tccgttgctg attcaattgt gatcgaatcg ccaacgctta aatcattttc 407341 ttccgctaat gtttcgttga tcactgttac ttttttgccg acatctgatt ttgtaatcgc 407401 gcgtccgtct gtgatttttg aatctccgtc agagaaatca tcgactaacg ctgtgctgat 407461 gacaccttca atagaaagat cagcttgaac catttgcggt ccgccttgtc ctccgccttg 407521 actgttttta gcgtttgagc ttgaactgct ggagctggaa tcacttgaac tagagctttc 407581 aatcgcatca aagtttcccg cgttggctga agctgatgtg gtgtaattgt agctcttcac 407641 atgatcaagc gctgcaagct tattcgcatc agacactttg atcggtgtgg attcgaagct 407701 gcgcttttca ccgctgtcct gctgtttttc catttgcttt tggcggtcaa cctgaagtgt 407761 cacgcttcca ccgagttcct gtctggccag ttcgcttgac ttttgtgctg ccgactggat 407821 ggcgaggcct gatagaacaa agacacatat gactgtaaac acaaataatt gcaataacgt 407881 ttttcccttt ttagccttca tattccaaaa ggcccgtttg ataaagttca tttatgttcc 407941 tccgtatagg tatttttatt gataagaccg cctctggggc gcgtcccctt gctgataaat 408001 taatagtagt ccaaaggtat gaaaaaaata tgaacaatct atttctagtt gatgaaataa 408061 aaactaacaa ttgtgaaacg caaaaccttc tgtttaaaat ggtgctatta tataaaaaag 408121 catcaaaaca accggaggat ataatgaaaa tattaatgat agaagataat gttagtgtat 408181 gtacgatgac ggagatgttc ttttttaaag aaggttttga agccgaattc gttcatgacg 408241 ggttagaagg gtaccagcgt tttacggaag aaaattggga tctaatcatt ttggatatca 408301 tgcttccatc tatggacggc gtgaccatct gcagaaaaat aagagagaca agcacggtgc 408361 cgattatcat gctgactgcc aaagacactg aatcagatca ggtcatcggt tttgagatgg 408421 gggcggacga ttatgtcaca aagccgttca gcccgctgac attggttgcc cgcatcaaag 408481 ccgtcatcag aagatataag gcgacaggca aagcggttat tgatgaagat atgattgaaa 408541 cggaatgctt taccattaat aagaagacga gagaagtatt attaaacgga gagcctgtag 408601 aaaatctcac gccgaaggaa ttcgatctgc tttattacct tgtccaaaat ccgcggcagg 408661 tgttctccag agaacagctg cttgagcagg tatggggcta tcaattttat ggagatgagc 408721 gaacggttga cgttcatatc aaacggctgc ggaaaaagct tgccagcgag gacaagcctt 408781 tcctgtatac tgtgtgggga gtagggtata aatttgatga agattaaata tttatatcag 408841 ctgctgctaa gccatatcag cattttgatt ttagcgtttg tcattatcat ttctctgttt 408901 tcccactttg tgaaggaatt tgcctatcag aacaaagtag aggaattgac gtcatatgcg 408961 gtgcagattg caaatgaatt ccaatccggc caggtggaca tgcgcaggct ctatccttat 409021 caggacattt taagcacaag aaagacgcaa tttatcatct ttaatgaaga gcagcagcct 409081 tattttcttc ctgaaggctt tcatcaccca ccaagggaac agctgaagaa atcagaatgg 409141 aataagctga aaaaagggca gactgtcacg atcagggcag atggccgttt tgatgatgaa 409201 gtgtcccttg tggcgcagcc tatatttgtt cagaacgaat ttaaaggcgc cgttctgctg 409261 atttctccga tcagcggtgt tgaacagatg gtcaatcagg tcaacctcta tatgttttac 409321 gctgtgatca gcacgcttgt gattacgatt cttgtgagct ggcttctgtc caaattccat 409381 gtcaagcgga ttcaaaagct gagagaagcg acagataaag tggcttccgg cgattatgac 409441 atccatttgg aaaacagcta cggggacgaa atcggcgtac tggcgtctga ctttaatatc 409501 atggcgaaaa aactaaagca gtcaagggat gaaatcgagc gccttgagaa gcggagaagg 409561 cagtttatcg ctgacgtgtc acatgaatta aaaacaccgc tgacgacgat caacggtttg 409621 gttgaagggt tgaacagcca tacgattcct gaggataaaa aggataaatg cttctcgctg 409681 atcagtgagg aaacgaagcg catgctgcgg ctcgtaaaag aaaatctgga ttatgaaaaa 409741 atcagatccc agcaaattac cttgaacaag ctagacgttc ctctgatcga ggtgtttgaa 409801 atcgtgaaag agcacttgca gcagcaggcg gaagaaaaac aaaacaagct gatgatccaa 409861 gtagaggatc acgtcatcgt acatgccgat tatgaccggt tcattcaaat tctcgtcaac 409921 attacgaaaa acagcatcca atttacgcaa aacggtgaca tttggctgcg cggaatggaa 409981 ggttataaag agacgattat tgaaattgaa gacacgggta tcggcattcc aaaagaggat 410041 attgagcata tttgggagcg attctataaa gcagatattt caagaacgaa cacagcatac 410101 ggtgaatacg gactcggtct ctcgatcgtc aggcagctcg ttgaaatgca ccagggcaca 410161 gtagaaatca agagtgaaga agggaaaggc acaaagttca tcatccgcct tcctttaacg 410221 gcaaaacagc aatagcatac agggcggcgc atcaactgat gcatccgcct tttttgcaca 410281 ccgcttcggt ttattgcgtg ctcccgaaaa caaagattgc gtgtttttcg ggttgggacg 410341 gcctataaac atgataaaat atgacataaa cagtttttga tgggagaggg tgaaggaatg 410401 aagagtgggg taattccttc ttcagcggtc ggtcaaaaaa ttaacgagtg gtacagatat 410461 atccggacat tcagcgtgcc ggatgccgaa gtgttaaaag ctgaaatcca gcaggaactg 410521 aaacacatgc agcatgattc caacttgctg ctttattatt cactaatgga attccggcac 410581 cagcttatgc tggattatct tgagccgtta gagaaattaa atatcgaaga ccagccaagc 410641 ctgtctgaat tatcaagaaa cattgacagc aaccaggcag atctcaaagg gctgctcgac 410701 tattacgtga atttttttcg cgggatgtat gaatttgata agcgggaatt tatttctgcc 410761 attacatact ataaacaggc ggagaaaaag ctctcctttg tcgcagacca tattgaacgg 410821 gctgaattct attttaaaat cgcggaagct tattattata tgaagcaaac gtatttttca 410881 ttgattaata taaaaaacgc ctatgaaatt tacgtggagc aggaaaccta taatgtgaga 410941 atcattcagt gccatttcgt cttcggggtc aacctgatgg atgaaagaaa tttcgaacaa 411001 gccgcacgcc atttcaaatt ggcgctcaac atggcccaag cagaacaaaa agcccagctg 411061 gttggaagag catactacaa tctcgggtta tgctattaca atcaagacct tctagaccct 411121 gccattgatt actttgaaaa agcggtctcc acatttgaaa gcagcaggat cgtcaattct 411181 ctcccgcaag cctatttttt aatcaccctg atttattata aacagggaaa acatgataaa 411241 gcttcggaat atcacaagcg gggctatgaa tatgctaaag aaacagacga tgcagactat 411301 gccgtaaaat tcgagttttt gcaatcccta tatctggatc agcccaatga agaaggaatc 411361 gaacgatgtt tccagtactt aaaaaataaa aatatgtacg ctgatataga ggatttagcc 411421 ctagaagtag caaaatatta ctatgaacag aaatggttta aactgtctgc ttcctacttt 411481 ctacaagttg aagaggcaag aaaacaaata caaaggagtg aaggtttgta tgaaattgaa 411541 atctaagttg tttgttattt gtttggccgc agccgcgatt tttacagcgg ctggcgtttc 411601 tgctaatgcg gaagcactcg actttcatgt gacagaaaga ggaatgacgt aagaacaagc 411661 cccttctcat tagcgagaag gggtttttct tttcaaaaaa acaccgcaag acatagtctt 411721 gcggtgccgc cttcatggag attacgttta tttagtagcc tcctacaaat gcagttccca 411781 caatgatcaa gaggataaat aacacaacaa tcaaagcgaa agaagttccg taacctgaca 411841 ttttgtgcac ctccttgcga gattgcttca gcaaatgctg caaaactgtg gcggacaggg 411901 tcccgcagag acggtcagca gcttagaagc cgccaacaaa cgcagtccct acgataatta 411961 atagaataaa caatacaacg attaaagcga aagaactgat gccgccgtaa ccgccgccgt 412021 tagagtatcc tgacataagg tttcacctcc ctatgaagga tactataaga tatgctgaac 412081 cgatccattt ggcagggata atagtggaca agagaaaaaa tgaagaattc ggctatatga 412141 aggtgatata aaaaaatagc gggcgctgcc gcccgctatt tatgtacgat taagagatca 412201 gcacgcccgc gaaaaattcc tggtataacg cttgaacggc ttttctttct tcggcttctt 412261 ttacgccaaa catcatgctc acttcagaag acccctgatt gatcatttcg atattcacct 412321 gtgcctctga taatgctttg gcggctcttg ccgttgtacc gacattgtgg cgcatcgctt 412381 cccctacaac cataatcagg gcgagatgat gctcgacgat gacttcatcg gcatgcaaat 412441 cctcttcgat ccgtttgatg acgctgcgtt cagtggcggc atccatttgc ccctgccgta 412501 aaatgattgt catgtcatcg attcccgatg gaacatgctc atacgtcaaa ccatgctcct 412561 ccaggatttg aagggctctg cggccaaaac cgatttctct gttcatgaga tacttgctga 412621 tataaatgct gcaaaaaccg gtgtcgctgg caatgccgac gacaggcccg tttgtgttat 412681 cccgcttgct gacgacgcgg gtgccttcgg ctgaggggtt gttcgtattt ttgatctgaa 412741 caggaatccc cgctctgaat gccggaatga gcgcttcatc atgaaacact gaaaaacccg 412801 cgtaggacag ctcccgcatc tctctatatg tcagctcgct gatttccttt ggattctcaa 412861 cgaaggacgg attgacagaa tacacagcgt ctacgtctgt aaagttttcg tacaaatcgg 412921 cttgtagtcc gttggcaaga atcgaaccgg taatatcaga accgctccgt gagaatgtga 412981 tcacatcgcc atccttgctg aatccgaaaa aaccgggaaa aatgatgagt ccgtcacgtt 413041 cccgaagacg atagaggttt tgataggatt caggaagaac ttgcgcgttg ccgggttcat 413101 ttgtcacaaa gaggccggca tccttcgggt ttacatattc cgctttgacg cctttataac 413161 ggaagtaagc ggcgatcagt ttggcattgt tatcctctcc gctggccttg actgcgtcaa 413221 ggtattgttc gggattgctt ttgtctcctt ctaaaagcgt aaacagatca tctctgattt 413281 tttcgataat gctttgcccc agctgaagct cattggcgat gagagcgtac cgttccacaa 413341 cagcttccgc cagttcaggt gcgctgcctg ttgccaaata ttgttctgca catgcgatta 413401 agagatcagt cactttcgta tcctcggcat agtgttttcc cggagctgaa acgactacag 413461 ctttccgtgc cggatctgag gtaacgatgt gaaacacctt gtcaagctgg gcgcctgaag 413521 caagtgagct gcctccgaat ttaacgacct tcatgtttac atctcctaat gtttaaaatt 413581 ttcacacaaa tttagtattt attatctctc tttcagtact gtaaatcaag ggggaatttc 413641 tttctcagga gaacatttgt atttttcacg aggaataatg ttaggtttgc tgaccgtatg 413701 cctgcgttat aaagataaat atggtaaaca gcctaacgtt ttgggatgga aaatggttag 413761 aatgattagt aaaattgata aatgactagg ttaatatttt taaagaatat tgactaaccc 413821 tataaaaatg gtaatatgta aatgataatg ataatcaatt actatatggc catattgttt 413881 tgagtccttg cggagtagga gatacgttct ttttgctgta aggatgtaag gaggcagcat 413941 gaagctacgt tacttattta ttctacttat catattagca gtcacatctg tatttatcgg 414001 tgtagaagat ctgtcgccgc ttgatctctt cgatttaagc aaacaagagg cgtcaacgct 414061 gtttgcaagc cgtttgccgc gattgatcag cattgtcatt gcgggattaa gcatgagcat 414121 ctgcggtttg attatgcagc agatcagcag aaataaattc gtgtcaccga cgacggcggg 414181 cacgatggat tgggcgaggc tcggcatttt aatttccttg ctgctgttta catccgccag 414241 tcctttaatc aaaatgctgg tcgcgtttgt ctttgccctt gcaggaaatt ttctgtttat 414301 gaaaatcctt gaaagaatca agtttaacga caccatcttt attccgcttg tcggtttaat 414361 gctcgggaat atcgtcagtt caatcgcgac atttatcgca tataaatatg acttgatcca 414421 gaatgtgtca tcatggctgc agggagactt ctctttagtc gtgaaaggaa gatacgagct 414481 tctttatctg agtattccgc tcgtcatcat tgcctatgtg tatgcggata aattcacatt 414541 ggccggtatg ggtgaaagct tttctgtcaa cctcggcctc aagtataaac gggttgtgaa 414601 catcgggctc attatcgtgt ccctgatcac gtctcttgtc attttgactg tcggtatgct 414661 gccgtttctc ggtttaatca tcccgaatat tgtatcgatt tacagaggag acaatctgaa 414721 gagcagcctg ccgcatactg tgctgttggg agcggttttt gtgctgtttt gcgatatact 414781 gggcagaatc attatcttcc cttatgaaat ctcgattggc ctgatggtcg gaatcatcgg 414841 cagcggcatt ttcctgttta tgctgttaag gagaaaagcc tatgcgtaac cagatgaaaa 414901 tagctttgct cgttggttta gccattgtat gtattggctt gtttttgttt tatgacttag 414961 gcaattggga ttacaccctg ccgagacgaa tcaaaaaagt cgctgccatt gtgctgactg 415021 ggggagcgat tgcgttttcg accatgatct ttcaaacgat tacgaacaac cgcatcctga 415081 cgccgagcat tttgggcctt gattctctct acatgctgat tcagactggc attatctttt 415141 tgttcggttc tgcgaatatg gtcatcatga ataaaaacat caactttatc atctctgttc 415201 tgctgatgat cctgttttct cttgttttgt atcagatcat gttcaagggt gaggggagaa 415261 atatcttttt ccttctgctt atcggaatcg tgtttggcac gctgttcagc agcctgtctt 415321 cttttatgca gatgctgatt gatccgaacg agttccaagt tgtgcaggac aagatgtttg 415381 ccagctttaa caatatcaat acggatttgt tatggctcgc gttcatcatc ttcctgctga 415441 caggcgttta tgtctggcgt tttacaaaat ttttcgatgt gctgtcgctc ggacgcgagc 415501 acgccgtgaa tttgggcatt gactacgaca aagtggtgaa gcagatgctg atcgtggttg 415561 cgattttggt ttctgtttca acagcgctag tcgggccgat tatgttttta ggccttctgg 415621 tcgtcaacct ggcgagagaa ttcctgaaaa catataagca ttcatactta atcgcaggct 415681 ccgttttcat cagcatcatt gcgctggtcg gagggcagtt tgtggttgag aaagtgttta 415741 ccttctcaac gacgctgagc gtcattatta attttgccgg cgggatttat tttatctact 415801 tgctgttaaa ggagaataaa tcatggtaga ggtcagaaat gtaagcaaac aatatggcgg 415861 gaaagttgtt cttgaagaga cgtcagtcac gattcaaaag ggcaaaatca cctcgtttat 415921 cggtcctaac ggcgccggca aaagtacgct gctgtctatc atgagccgcc tgatcaaaaa 415981 ggattccggc gagatttaca tagacggaca agagattgga gcatgtgaca gcaaagagct 416041 tgccaagaaa atgagcattt tgaagcaggc gaaccaaatc aatatcaggc tcacgatcaa 416101 agacctcgtc agttttggca ggtttccgta ctcacagggc cggctgacag aggaagactg 416161 ggttcatatc aaccaggcgc ttagctatat gaagctggaa gacattcaag acaaatactt 416221 ggatcagctg agcggcggac agtgccaaag ggcatttatc gccatggtca ttgcccagga 416281 cacagattat atctttctgg atgaaccgct gaacaatctg gatatgaaac actcagttga 416341 aattatgaaa ctgctgaaac ggctggtaga ggagcttgga aaaacgatcg tgatcgtcat 416401 tcacgatatc aattttgctt cagtctattc tgactatatc gtcgctttga aaaacggccg 416461 aatcgttaaa gaaggaccgc ctgaagaaat gatagaaaca tcagtgcttg aggaaatcta 416521 cgatatgacc atcccgattc agacgattga taatcaaaga ataggtgttt atttttctta 416581 atatatagaa gaggtgagga gcatgaaaaa gttcgcgtta ctattcatcg ctttggtcac 416641 tgccgttgtc atttctgcat gcggaaacca aagcacaagc agcaaaggtt ctgatacaaa 416701 gaaagaacaa atcacagtga aacaccagct cgacaaaaac ggcacaaaag taccgaagaa 416761 ccctaaaaaa gttgtcgtat ttgactttgg aagcttagat acattagata aactaggact 416821 tgatgatata gtagcgggcc tgccgaaaca agtccttcct aaatatctgt ccaaattcaa 416881 ggatgacaaa tacgctgatg tcggcagctt aaaagagcca gacttcgaca aagtggcaga 416941 attagatcct gatctgatca ttatttcagc aagacaatct gagtcttaca aagaattctc 417001 taaaattgcg ccgacgattt accttggtgt agatacagcg aagtacatgg aatcatttaa 417061 atcagacgct gaaacaatcg gtaaaatctt tgataaagaa gacaaagtga aagatgagct 417121 cgcaaacatt gatcactcaa tcgcagatgt aaagaaaacc gctgaaaagc ttaacaaaaa 417181 cggtctcgtc atcatggcga acgatggaaa aatcagcgcg ttcggcccta aatcaagata 417241 cggcctgatc catgacgtat tcggcgtggc tccggctgat caaaacatca aagcgtctac 417301 gcacggacaa agtgtttctt acgagtacat ttcaaaaaca aaccctgatt acttgtttgt 417361 tattgaccgc ggtacagcaa tcggagaaac atcatctaca aaacaagtcg tggaaaacga 417421 ttatgtgaaa aacgtaaacg cagtgaaaaa tggtcatgtc atctaccttg attctgctac 417481 ttggtattta tcaggaggcg gacttgagtc tatgacgcaa atgattaaag aagtgaaaga 417541 cggtttagaa aagtaaaacc aaaaagagcc tccgctaaat agcggggctc tttttttgtt 417601 aatcagcgtg ccggctgctg ttcggcaggg cgctgaggtt tctttaatgt gaatgagaga 417661 aggaagccga caagtgcaat gacggcagcc actataaaag cggcgttcat gccgtgcagg 417721 gcggcgtgct tcacatttgt cgtgcctgca tgtgccgcct ggttgctcat cacggaaacc 417781 aatagtgcgg ttccgatcga gccgccgact tggcgaatcg tgttgttcat cgcagttccg 417841 tgcggaatca agtggcgcgg cagcgcattg attccggctg ttgtcaccgg catcatgatc 417901 atggcggtgc ctaagagacg aacggtgtat aaaacgacaa tccaagcgag tgacgtatgg 417961 tcagtcagct gcataaacgg cagagatgtc aggaagatga tgcagaaacc ggcaatcgcc 418021 agccctcttc cgccgacacg gtcaaaaatt ctgccgataa tcggcgacat aaagcccatc 418081 acaacggctc ccggcaggag cataagccct gtatcaaaag ctgtgacgtc tctgacattt 418141 tgtgtataaa gcggcaggat ggtttccgta ccgatcaata atgcaaagac gagggttccc 418201 agcagtgttg ttaagctgaa aacgccaaac gtgaagacgc ggaattccag catcggtttt 418261 ttaagcttca tttgtcttgt gataaacaag agcagcgcga tgacacccac cagcagtgaa 418321 atcaagacgg ttgaactgga ccagccataa gagccgacgc ttgagaagcc gtacagaagg 418381 ccgccgaacc caaatgttga aaggatgact gataaaatat caatctgtgt ttttcttaaa 418441 gtcgtcacgt ttttcatcag gatgctggca agaatcaaat caatcacagc aaacggaaga 418501 ataatataaa acaatgatct ccaagagaaa gcttcgacag cccatccgga aagagtcggt 418561 ccgatcgcag gcgcgaatga gatgaccaat ccgaccatac ccatagcctg gccgcgcttt 418621 tcaatcggaa agattgtcag gaatacagtc tgcatgagcg gcatcataat gccggctcca 418681 gccgcttgaa tgatacgcgc tgtcagcaga accgggaagt tcggcgcgaa cgctccgacg 418741 actgttccgg cagtgaaaat gctcattgct gtgatgagca gcgcccggct tgtgaatttc 418801 tcaattaaaa acgcggtaat cggaattaaa atcccgttgg ttaacataaa tgatgttgtc 418861 agccattgtg cttggttggc atcgacattg aaatccctca tgatatgggg aagtgcagta 418921 atcaacaatg tctggttcaa aatcgccaca aacgctccgg ctaacaaaat gccgacaatg 418981 acagaacggt taaaaggttt ttgttcaata cttgtgttca atacatatcc cttcttttct 419041 ctaagtaatt aacagtgttt ttaacatgga aacgggctgt gttaaaacac cggtttgttc 419101 cagatagcca atcagtgatt tgagtaaaaa agcgcggggt tcttccttct tcgcttcttc 419161 ctccagcata gcggctgcgg atgtcagttc atctacgtca tagtccgcgg cggacaggga 419221 agagatgcct ttatgtaatt ccttcaggct ttccgataat aggactgatt tatcctttgg 419281 cttgtaggag gatgctgaat gaatataaag ctcgatggct tcgggcggaa gaagagactg 419341 gcgggtttcc ctgtttttga taatctgatt gagggtgctg atgataaact ctgcgatcgg 419401 gtcaagctca agcggttttt cctcgatttt gatcagcatt aaaaactcac gcatcatgcc 419461 gtgaagaatg ataaccaaat cccacacaaa cgggagaatg gtttctccat acgcctggat 419521 cagcgaatcg cggtgccagc agataatcgt cgatctggtc tgatggatat gctgtttgac 419581 ccggtcattg tgcagcttgg ggtttccgta ggtcagcata ttgaaaaact gctgattccg 419641 cctgaagccc tccagttcca ttttgacctt ttgcgtcaaa cgctcctccg gtgtaagtgc 419701 tgtattttcc tgaagtcttg aggccgcggc caccatttgc ttctggttaa atgacagcag 419761 ctccaaaagc agatcttctt tagattggaa cagcttatat atcgaagctt ttgacatctt 419821 acattcttct gcgatcgcct gcatggaaac cgacgtaaaa tccttttccg aaaaaagctt 419881 tcgcgcggct aacaagatat ctgttttttt atcaagcatc tcatggcttc cttctttctt 419941 gaacattaga aaacccattg gttcacagaa aaccaatgag taacaatgaa aaaattttac 420001 cagataaaca aaatagaagt caatggattt taaccgggta aatgaaaggc ctgccggaaa 420061 atccgacagg ccgaataaga gcttattttt caactttaaa tccttgtttt tcaagcattt 420121 cacggatgtg cggatagtac aggcgctcat agtaggaagc gatgctctgt gaccagtttc 420181 ttgtttcttt tccgtttgtc cgtttattca tgtattcaga catctgttcg tcgtatgcct 420241 gaatgtgaga cgtcagctca tcctgattca aataagtttc ctgatgattg acagcttcct 420301 gcggcaagcg cggttttttc gctgaacggt cggcaggatg cccaatgaca aggccggata 420361 aagggaacac gtatttcgga agctcaagca gttcgatcag ctcttgaggg tttccgcgaa 420421 ctgcaccgat cggaactgtg ccaagtccga gtgactcagc cgctgctgtt gctgtgccga 420481 gggcaatacc agcgtctact gcgccgacaa gaacagattc caatccattt gtgatttcca 420541 ttttgaaatc atgcagatct tcaagcgcaa ttttggcccg gttaaaatct gcgcagaaca 420601 gcaggaaaac aggagcttga tcgatccatg gctggccgcc tgccagctcg gagattttct 420661 ttttgcgctc tttatcctgg actgtgatca cagtcacttg ctgtccgttg atagaagaag 420721 gggctgattg caccgcttca atgatttggt ccaattgctc ctgagctaca ggctcatctg 420781 tgtagctgcg aatcgagcgg tggtctgtta aagatttaat cacttcattc atatgagaca 420841 cccttccttt actcgctaag ctctgtgcgg acaacatcaa gaggagcgct cagcagttct 420901 tttccttttg cgacaaaccc ttggaaatgc gcagtttcgt tatggaattt cattgccgct 420961 tcatctttcc atttttcaag catgacaaat gtattttctt cgcctacttt ttcgaatagg 421021 tcgtattgcg cgttgccttc ctcagctctt gaatgctgaa caagtgattg agcctcgctc 421081 aaaaattcct cgcgtttttc tggttttact ttgatgtaag cttgtaatac gatcatgtaa 421141 atctcctccg tcgttatgcg aatttattgt tcgaatttca tcgaactaaa tgtaacatgt 421201 attctaaatg aggtaaagga aaaaccctta tatagtaaaa ttgtcattct aattgttgta 421261 tgatacattt gtgtcatgaa cattccaaac catccagaaa cagaaacatt gcagctgaca 421321 aaggttcttc atgcacttag tgatccgctt cgtttagagc tcgtcaagca attagctgaa 421381 gcaaaagaaa aaacgtgcag cacctgtgca gatgtgcagg ttgccaaatc gactttgtcg 421441 catcatttta aagttttgag agaatcaggc atcgctcaag ttcggataga aggaaagcgc 421501 cggtattatt cgcttcgcgc tgaagacctt gaaaaggcat ttccgggact gcttgaagcc 421561 gtgctgaatg tagaccagga ccgctggtga atcaatcccc tgtaacgggg atttttttat 421621 gtccgtaaac cgctttgaaa agccgctgca caccctcctg aatatcttct tccttcagcc 421681 gtgcaaagcc gataatgaga gcaggcctgc ccgtttgccg cttgttttcc ttcaagttaa 421741 atcggctcat tccgaatatt tcaagctgca gcccggcagc atgtgacagg atgtcttgtt 421801 cggtgcgcct ggtatcaaat tcggtaacaa aatgcagccc cgcatttgcc ccttttacgg 421861 taacctctcc gctgaactct gcttctaaag cggtgatcag gcgttctctc ttttctttat 421921 aatgctgctt catttttttt atatgcttct gatattcacc agactcgata aattcctgca 421981 gggtgagctg tgtgagtgat gagcaagtct gcagatcata gccccgctgt ttgtatgccc 422041 tcaacagctc aggcggcaac accatatagc tgatccgtaa gccggggaga agggactttg 422101 aaaaggttcc catatagatg acattttgaa aacggtcgag gctttgcagc gccggaatac 422161 tgtctacatc atatgtgaat tcactatcat aatcgtcctc aatgatatat cggcgcggct 422221 cctcggctgc ccagttcagc agctgaattc ttctggatac aggcataatc gttccggacg 422281 gaaactgatg cgacggggtg gtcaccagca catctggctg ctgtctggtg atttcagcaa 422341 tcgacatgcc tttttcatcc agcatgatcg tctttacttg ttttccggca ttcttcaaaa 422401 gctgatacat gcgcctgtag ccaggctcct ccatcgcata cacggcttcc ttgggtaaaa 422461 gctcagtcaa cagctgcatg agcacctgtg tgcctgcccc tatgatcatt tgttccggcc 422521 tgcattttac acccctcgtc agggaaatga gcctcgtaat ggccgctctc acttcatata 422581 tcccttgcgg atgtgacata tcgccgagcg tgcggtatga gcgggaggcc gctttttgct 422641 cgcagcggaa ccagcttttg atcggaaaat ggtctgtatc ggaactcatg tgtgaaaacg 422701 atatccaatc gctctggtcg atgtgaatct cttttaggtc atccggcagt gcaaatggag 422761 ggtgctcctc ggcggaaaac atgtctagtt cctccacgaa gaaacccttt cgttcaatgg 422821 cgtacaaata cccctcagcc agcagctgct gataggctga attcactgaa tttacgctga 422881 ccttgagatt ttcagccagc tcccgcttgg agggaacctt cgagtgcggc agcagattgc 422941 ggctgaggat ttcttttttc agcttttgat aaatttgctg atagatataa tcggcttgtt 423001 ctgaacgatc gagtgtaatc gtgatatcca ttttgtagtt tctccttctg ataccatcaa 423061 aaagttataa ttggtacttt tcatcatacc aaagagaagt cagaatgata agaaaatacc 423121 gacaggggga tattcacatg agtcaaacaa cagcaagcat cacaactgca caatggcagc 423181 aaaaacggga tcaatttgtg tcaaaaggtg tgagcaacgg caaccgcagt ctggcggtca 423241 aaggagaagg ggccgagctg tacgatctgg atggccggag atttattgat tttgcaggcg 423301 ccatcggcac gttaaatgtc ggacactcgc atccgaaggt ggttgaggct gtgaagcggc 423361 aggcggagga gctgattcat cctggtttta atgtcatgat gtacccgact tatatcgaat 423421 tagcagaaaa actgtgcggc atcgcgccgg gcagccatga gaaaaaagcg atttttctta 423481 actcaggggc agaagcggtc gaaaacgctg tgaaaatcgc cagaaagtat acaaagcgcc 423541 aaggcgttgt ctcgtttaca cgcgggtttc acgggcgcac gaatatgacg atgagcatga 423601 caagcaaggt aaaaccttat aaattcggtt tcgggccttt tgcgccagag gtttatcaag 423661 cgccgttccc ttattattat cagaagccgg ccggcatgag tgatgaaagc tatgacgata 423721 tggtcattca agcattcaat gatttcttta tcgcttcagt ggcgcctgaa acggtggcgt 423781 gtgtcgtgat ggagccagtg cagggagaag gcggatttat tattccttcg aaacggttcg 423841 tacagcacgt cgcttcattc tgcaaagaac acggcattgt ttttgttgct gatgaaatcc 423901 aaaccggctt tgccagaact ggcacttatt tcgcaattga gcactttgat gtagtgcccg 423961 atctgatcac ggtttctaaa tcgcttgcgg caggcctgcc attaagcggt gtgatcgggc 424021 gtgcggaaat gcttgatgcg gcagcgccag gggagctggg cggcacgtat gccggcagcc 424081 cgctcggctg cgcggcggct ttggcagtct tggatattat cgaagaagaa ggactgaatg 424141 agcgatctga agaaattggc aaaatcattg aagacaaggc gtatgagtgg aaacaagaat 424201 tcccgttcat cggtgacatc cgcagactcg gggcgatggc cgcaatcgaa atcgtcaagg 424261 atcctgacac gcgtgagcct gataagacaa aagcagcagc gatcgcggcc tatgcgaatc 424321 aaaacggatt acttttgctg acagcgggaa ttaacggtaa tatcatccgc tttttgacac 424381 cgctcgtcat ctcagacagc ctattaaatg aagggctcag catcttggag gcgggcctgc 424441 gagcttaatc attggaaaga aaatggccgg gtctgctatc attttaagta atcatgaaaa 424501 gaaaggaatg ttcaatatgc cagatcaatt aacggtctac aacccggcta cgggcgagga 424561 gatcaaaacg attcctcagc aatcagccac agaggtagaa gaagccattg aacgttcaca 424621 tcaagcgttt aaaacgtggt ctaaaacatc agcgaacgaa agaacgtctc ttttgaaaaa 424681 atggtatgag ctgattgttg aacataaaga agagcttgca gatttaatta caaaggaaaa 424741 cggaaaacca taccaggaag cagtcggcga ggtactttac ggcgcaggct atatcgaatg 424801 gttcgcagag gaagcgaagc gtgtgtacgg aagaacggtc ccggccccga caactggtaa 424861 acgaattgtt gtcacacgcc agccggtcgg ccccgttgct gctatcacgc cctggaattt 424921 cccgaatgcg atgattacac gcaaagcggc gcctgctctt gccgccggct gtacatttat 424981 catcaagccg gcgccggaca caccgctgtc tgcttatgaa ctagcgcgcc tcgcatatga 425041 agcgggcatt ccgaaggatg ttcttcaggt tgtgatcggc gatggagaag aaatcggaaa 425101 tgtgttcaca agcagtccga aaatccgcaa aatcacgttc acaggctcaa cacctgtagg 425161 gaaaatcctt atgaaaaaca gcgctgacac cgtaaagcac gtctcaatgg agctcggcgg 425221 acacgccccg ctgatcgtag atgaagatgc ggacattgac cttgccgttg aacaggcgat 425281 ggcgtccaaa taccgaaacg ccggccaaac ctgcgtatgt gccaaccgcc tgatcgttca 425341 tgaatccatt aaagatgaat ttgctgcgaa actgagcgag caagtgtcta agctgaaagt 425401 cggaaatgga cttgaggaag gcgtcaatgt cggcccgatt atcaacaaac gaggcttcga 425461 aaaaatcgtc agccaaatag atgatgcggt tgaaaaaggc gcgaaagtga ttgctggggg 425521 cacatatgac cgaaacgatg acaaagggtg ctactttgtg aatccgacag tgctcaccga 425581 tgtcgatacg tccatgaaca tcatgcatga ggaaacattc ggcccggtcg ccccgatcgt 425641 cacgttttct gatattgatg aagcgattca gcttgccaac gatacaccgt atggcttggc 425701 tgcttacttc ttcacagaaa actaccgccg cggcatctat atttccgaga atctagagta 425761 tggcattatc ggctggaatg acggcggacc gtcagcggtt caagcgccat tcggcggaat 425821 gaaagaaagc ggcatcggcc gtgaaggcgg ttcagaaggt atcgagccgt accttgaaac 425881 aaaatatttg tccatcggtt tataaaagaa tgcacgctcc tgagagctgc cggattttcc 425941 ggcagctctt tttgtgttcc ggcgaataat cacaacaatt ccagccaaaa taacagcaaa 426001 tacattttga aagaaggttc cccaacaatg gatttattat tggctcttct cccggctttg 426061 ttttggggga gcattgttct cttcaatgtg aaattaggcg gcgggccgta cagccagaca 426121 ctgggaacga cgatcggggc actcattgtt tctatcgtta tttacttttt tgttcagccc 426181 gttctgtccc ttcgcatttt tattgttgga atcgtatccg gcttattttg gtcacttgga 426241 caggccaacc agttgaaaag cattcaattg atgggcgtgt cgaaaacaat gccgatttcc 426301 acaggaatgc agctcgtttc cacctcgctg ttcggtgtga tcgtgttccg cgaatggtca 426361 acaccgattg cgattacgct tggcgttctc gctttgatct ttatcattgt gggaatcatt 426421 ctcacgtcct tggaagataa gaatgataaa aaagagggcg agccaagcaa tttgaaaaag 426481 ggcattttga ttctccttgt ttcgactctt ggttatttgg tttatgtagt cgtggctaga 426541 ttattcaatg tgtccggctg gtccgcgctg ctgccacagg caattggcat ggtggtcggg 426601 gggttagttt taacctatag acacaaaccc tttaacaagt atgcgatcag aaatattctc 426661 ccagggttaa tctgggcagg cggaaatatg tttttgttta tttctcagcc gcgagtcggc 426721 gttgcaacga gcttttccct ttcacaaatg ggaattgtca tttctacgct cggcggtatt 426781 ttcatcctgc gtgaaaagaa aacgaaacgc cagctaatag caattgcgat cgggattatc 426841 ctgattattg ccgccgccgt attcttagga atcgccaaaa caaattcata acaaatggag 426901 gaggatgtat atgtatccgg atttaaaagg aaaagtcgtc gctattacag gagctgcttc 426961 agggctcgga aaggcgatgg ccattcgctt cggcaaggag caggcaaaag tggttatcaa 427021 ctattatagt aataaacaag atccgaacga ggtaaaagaa gaggtcatca aggcgggcgg 427081 tgaagctgtt gtcgtccaag gagatgtcac gaaagaggaa gatgtaaaaa atatcgtgca 427141 aacggcaatt aaggagttcg gcacactcga tattatgatt aataatgccg gtcttgaaaa 427201 tcctgtgcca tctcacgaaa tgccgctcaa ggattgggat aaagtcatcg gcacgaactt 427261 aacgggtgcc tttttaggaa gccgtgaagc gattaaatat ttcgtagaaa acgatatcaa 427321 gggaaatgtc attaacatgt ccagtgtgca cgaagtgatt ccttggccgt tatttgtcca 427381 ctatgcggca agtaaaggcg ggataaagct gatgacagaa acattagcgt tggaatacgc 427441 gccgaagggc attcgcgtca ataatattgg gccaggtgcg atcaacacgc caatcaatgc 427501 tgaaaaattc gctgacccta aacagaaagc tgatgtagaa agcatgattc caatgggata 427561 tatcggcgaa ccggaggaga tcgccgcagt agcagcctgg cttgcttcga aggaagccag 427621 ctacgtcaca ggcatcacgt tattcgcgga cggcggtatg acacaatatc cttcattcca 427681 ggcaggccgc ggttaaacat aaaaagcgac ccagacatga catctggatc gctttcttta 427741 ttaggcacgc tttttcttta caagtgctgc tacagataaa ataatggcag ccgcagacag 427801 caccatcgct gtaatgtcta gagctgaaga acctgagttt tcggaatcgt cttctgtttt 427861 cgtggcgccg tgctcatctg tcacttgctt tgcagacgtg atgtttgtaa tggaatgagg 427921 tgtatcggca tcctcgtcac ctgtccactc aacaatgctg ccgtctttgt aatattggta 427981 tgcgtcccaa gcagcttcct ccgctttgtc agggtttttg gcaacaaagg taaactgctg 428041 gaactggcct tcctgaatgc ctccgtcagt cgcctcccat gtcacggata ctgatttgtc 428101 atcatgtttt tgagtggaaa ccttccagcc cggaattggc tcatattgct ggaattcaac 428161 atccttcggc attttgagga caaccttcgt tgtcggcaga tttttctcag aaggaacctt 428221 cattgtatac gtttcccaag agcctgcagc agactcagcc ggttttacag aaacatgcgc 428281 gctggcaggg gccgtaaaga ataagaggga gccgacaata gccggacata gtgtcaatgc 428341 gatttttttc aacaacgtaa acactcctta attggtcttt gtaaacatga tattgatttc 428401 gttaaagtcg ccggtcaggc cgtggacttt gatcttccag tttccttttt cattaatcga 428461 caggttttga tcttggaaga cgccttttgt tttttctttt aatgtaaagg tgcttttgtt 428521 ttcgctgcct gacaggcctg ttttataaac ggttaacgtg atttgctgga tgtttttcac 428581 gggatcaccg ttatggtcgg tgacccgcag ctcaaaaaca ttttttccag gctggtttgg 428641 gctgatgctg agagaaacgc tttgtccgtt ctctatcgct ttggtttggt agaacggttc 428701 cggcgctggc tcaggcgggc ttggcaggct tgtaaacacg gccgctgtga tcaatacagc 428761 gatgccgatt gcccactccg ctttcaacgt tcggctgatt cctgtgcggc gctgctttct 428821 ggtaagcaga aaatgaattg cgcctaagac cagcatgaaa acaaacagcc cgcttttcac 428881 taaaagagct tgtccgtacg ctgtatggaa cagtgaatcc attgaacgaa tgatgaaaaa 428941 tccattgagc aagcctgaaa acaaaatgac gccgactgca gtgagcgccc atggggagaa 429001 ccgtctgacc gtctcccacg cgagcgtttt gtcaggctgc ctccattctt ttgagagcag 429061 caaaacgagt gccgctattc cgccgaccca gatggaagcg gaagttaaat gaaggaaatc 429121 catcaaaatg ccgaccgttt tttcttcaac gacagcagca tgcccggtaa acgccttggc 429181 aagcaggaga ccgaaaaaga aaatgagcgg cgctgtccaa tagccaaagg atgaaaagcg 429241 gtttttccgt atcgcaggga tgacagacag tgcgagcagc acgaacagcg cagcctgtat 429301 gatccaaatg gagccgcctg ctgtctcaaa cagtgtttct ctgatgtagc ccggctggaa 429361 tgcgctgccc cagccgccgc ctgcgttcgc ttttgtctga atcggaagct gaagcaaaag 429421 cgccagcccc aatgctgcga tcgagccggt caggatacgt ctcgtccgtt tgacgagctg 429481 ttctgatttc cctttatacc agaaaagatg gaagaaaacc gttccgataa acagagataa 429541 ggctgtatac agaatcgcgc gatctgctgc tgttcccgga ttcagcgctg aatcggctgc 429601 tttttggctg ctgaatccgc catccgcttt cccgatactg aacggaatga cgccggaaac 429661 aggatgtcca tccgcggata cggcattcca ttccgctctg tacacatctt taggcagatt 429721 cttcttcagc ttcactgtca tgatgtgatg attatctttt ttgatttcag tcttgtccgt 429781 atccacacgg tcgccgtttg aattatagac tttaatgtaa tgaaaccctt cttcaaccgg 429841 ttcattaaat tcgatttcca cctgcgcagg ggcgcttttt aattcgctgt tttccccagg 429901 tgaagatttg acaatatagg cgtgagcaaa gcttgttttc ggcaggaaaa caagaaaaag 429961 cagaaggatg atccaccatc tgtttcgctt catcactcag acaccacctt ccgctgtatg 430021 tgttgtgtta tttcttggtg caggtgcagc gtttctttcg gtcttgaagc atgtcttcca 430081 gcgcttggtc gaaagtgcag acggctccgc cgaatccttt ttgaaatcgt tcggcatggt 430141 caagtgtcgc aaacggaatg gcctgcggct ggcagcagtg caggtttaat tcagcattta 430201 cgacgaaata agccgaaccg gcactgacgg ttgtctgtaa cagaaaatct ctgcaaatca 430261 agtgtgaaac ctcttccgtt ttatccgcgt aacgcaaaaa cgcgcaatgt gcgcagcata 430321 gctgttcaat gtcttggttt accgtaatca gctgaaccga atgagcttga ttgacgggct 430381 tcaagcaata gctgcacata tgatctgttt gaggtgttcg gacggggagc gtgatgccgc 430441 cggccgtttt aatgacctga tttgactgaa ccagctgatt gacatctcta tataccgtca 430501 tttccgaaac gccgaacctt gcgctgatgt cagaaattct aagcgagcct tcttctttca 430561 gccacttcag tatgtgttgc tgtctattaa tcggaagcat tcatacaccc tcttcattaa 430621 gatctattta agcgtagagg attttagaga cggagacaag taagtggatg ataaaaaatg 430681 tgaaaatgtg ttgaacagca acaaaacgaa acagaaggga ctctggtata atagacagat 430741 ggaatagaaa gtgaggaata ccctatgaaa gaaacaccat gcccgaactg cggcaaacct 430801 ttgacaggcg atatggtcag atcatcaaat gtgccttgtc aatttcgctg cggccactgc 430861 cgggaacggc tttatgaata taaagtttca gctccgatta tgctggtatc attagcggcc 430921 atcgtgctgc ttatttatct tttgatgctc ctccgcaatg cggcaggctc agtgctgcca 430981 gctgtacagc acgtgccgat ggctgtattt gcgcttgtgt gcgcgtatcc cgtttttatt 431041 gtgagtgagc ggatgattgc aaagtacgtg attcaaaatg gcaacatcat ttatagagga 431101 aagagaaaag gctcctgaaa ccaggagcct ttttattttt aaaaaattgt cacagtcatg 431161 tgccaaagtc ctctttactt tcaattgtat agggactgta agcgttttaa catagagtca 431221 aagggaagca tcattctctg aacatatttt tgtatcttac agcgacaaac aaaacaggga 431281 gggtttatat atgcagcagc aagaacagca gcaaggcggc atgaaagtga aagtgcaacg 431341 ctttgggagt tatttgagcg gaatgatcat gccgaatatc ggcgcgttta tcgcgtgggg 431401 tatcattacc gcgctgttta ttccggcagg atggtttccg aatgaacagc tgaacacgct 431461 ggtcagcccg atgattacgt atttattgcc gcttttgata gcgtatacag gcggaaaaat 431521 gatctacgac caccgcggcg gagttgtcgg agcgacagcg gcaattgggg tgattgtagg 431581 atcggatatt ccaatgtttt taggcgcaat gattatgggt ccgcttggcg gatacctcat 431641 taaacagact gataaattat tcaaggataa agtcaagcaa ggctttgaaa tgctgatcaa 431701 caactttacg gcagggattg tcggcgcggc tttaacgatt ctcgcgtttt acgccatcgg 431761 cccggttgtc ttgacgctaa ataaattgct ggcggctggt gtggaagtca ttgtacacgc 431821 taatttactg ccggtagcca gtgtttttgt agaaccggcg aaagtgttgt tccttaacaa 431881 cgccataaac catggaatct taagcccgat cggaatcgag caagcatctc aaacaggaaa 431941 atcaattctg tttttagtag aagcaaaccc tggaccgggg ctcggcattt tgctggccta 432001 catgttcttt ggcaaaggat cttcaaaatc aacggctccc ggtgcggcga tcatccattt 432061 cttcggaggg attcacgaga tttacttccc gtacattctg atgaaaccgg ccctgattct 432121 cgcagccatt gccggcggag caagcggact cttaacattt acgatcttta atgccggact 432181 tgtcgcggca gcgtcaccgg gaagcattat cgcattgatg gcaatgacgc caagaggagg 432241 ctatttcggc gtattggcgg gtgtattggt cgctgcagct gtatcgttca tcgtttcagc 432301 agtgatcctg aaatcctcta aagctagtga agaagacctg gctgccgcaa cagaaaaaat 432361 gcagtccatg aaggggaaga aaagccaagc agcagctgct ttagaggcgg aacaagccaa 432421 agcagaagaa gcgtctgagc tgtctcctga aagcgtgaac aaaattatct ttgcgtgtga 432481 tgcgggaatg ggatcaagtg ccatgggggc atccatctta agaaacaaag tgaaaaaagc 432541 ggagcttgac atcagtgtga ccaacacggc cattaacaat ctgccaagcg atgcggatat 432601 tgtcatcacc cacaaagatt taacagaccg cgcgaaagca aagctgccga acgcgacgca 432661 catatcagtg gataacttct taaacagccc gaaatacgac gagctgattg aaaagctgaa 432721 aaagtaatct tatagaaaga gagtgattgt catgcaagta ctcgcaaagg aaaacattaa 432781 actcaatcaa acggtatcat caaaagaaga ggctatcaaa ttggcaggcc agacgctgat 432841 tgacaacggc tacgtgacag aggattacat tagcaaaatg tttgaacgtg aagaaacgtc 432901 ttctacgttt atggggaatt tcattgccat tccacacggc acagaagaag cgaaaagcga 432961 ggtgcttcac tcaggaattt caatcataca gattccagag ggcgttgagt acggagaagg 433021 caacacggca aaagtggtat tcggcattgc gggtaaaaat aatgagcatt tagacatttt 433081 gtctaacatc gccattatct gttcagaaga agaaaacatt gaacgcctga tctccgctaa 433141 aagcgaagaa gatttgatcg ccattttcaa cgaggtgaac tgacatgatc gccttacatt 433201 tcggtgcggg aaatatcggg agaggattta tcggcgcgct gcttcaccac tccggctatg 433261 atgtggtgtt tgcggatgtg aacgaaacga tggtcagcct cctcaatgaa aaaaaagaat 433321 acacagtgga actggcggaa gagggacgtt catcggagat cattggcccg gtgagcgcta 433381 ttaacagcgg cagtcagacc gaggagctgt accggctgat gaatgaggcg gcgctcatca 433441 caacagctgt cggcccgaat gtgctgaagc tgattgcccc gtctatcgca gaaggtttaa 433501 gacgaagaaa tactgcaaac acactgaata tcattgcctg cgaaaatatg attggcggaa 433561 gcagcttctt aaagaaagaa atatacagcc atttaacgga agcagagcag aaatccgtca 433621 gtgaaacggt aggttttccg aattctgccg ttgaccggat cgtcccgatt cagcatcatg 433681 aagacccgct gaaagtatcg gttgaaccat ttttcgaatg ggtcattgat gaatcaggct 433741 ttaaagggaa aacaccagtc ataaacggcg cactgtttgt tgatgattta acgccgtaca 433801 tcgaacggaa gctgtttacg gtcaataccg gacacgcggt cacagcgtat gtcggctatc 433861 agcgcggact caaaacggtc aaagaagcaa ttgatcatcc ggaaatccgc cgtgttgttc 433921 attcggcgct gcttgaaact ggtgactatc tcgtcaaatc gtatggcttt aagcaaactg 433981 aacacgaaca atatatcaaa aaaatcatcg gtcgctttga aaatcctttc atttcggacg 434041 atgtgacccg cgtagcgagg tcacctctca gaaaactggg agaaaatgat agacttgtag 434101 gcccggcaaa gaaaataaaa gaaccgaatg cactggctga aggaattgcc gcagcactgc 434161 gcttcgattt caccggtgac cctgaagcgg ttgaactgca agcgctgatc gaagaaaaag 434221 gatacagcgg cgtacttcaa gaggtgtgcg gcattcagtc ccatgaaccg ttgcacgcca 434281 tcattttaaa gaaacttaat caataaccga ccacccgtga cacaatgtca cgggcttttt 434341 ttactatctc gcaatctagt ataatagaaa gcgcttacga taacagggga aggagaatga 434401 cgatgaaaca atttgagatt gcggcaatac cgggagacgg agtaggaaaa gaggttgtag 434461 cggctgctga gaaagtgctt catacagcgg ctgaggtaca cggaggtttg tcattctcat 434521 tcacagcttt tccatggagc tgtgattatt acttggagca cggcaaaatg atgcccgaag 434581 atggaataca tacgcttact caatttgaag cagttttttt gggagctgtc ggaaatccga 434641 agctggttcc cgatcatata tcgttatggg ggctgctgct gaaaatccgg agggagcttg 434701 agctttccat taatatgaga cccgccaaac aaatggcagg cattacgtcg ccgcttctgc 434761 atccaaatga ttttgacttc gtggtgattc gcgagaacag tgaaggtgaa tacagtgaag 434821 ttggcgggcg cattcacaga ggcgatgatg aaatcgccat ccagaatgcc gtgtttacga 434881 gaaaagcgac agaacgtgtc atgcgctttg ccttcgaatt ggcgaaaaaa cggcgcagcc 434941 atgtgacaag cgccacaaag tctaacggca tttatcacgc gatgccgttt tgggatgaag 435001 tctttcagca gacagccgct gattatagcg gaatcgaaac atcatctcag catattgatg 435061 cgctggccgc tttttttgtg acgcgtccgg aaacgtttga tgtcattgtg gcgagcaact 435121 tgttcggtga tattttaacc gacatcagct caagcctgat gggaagcatc ggcattgcgc 435181 cttctgcgaa catcaatcca tccggcaaat atccgtccat gtttgaaccg gttcacggct 435241 cagctcctga cattgccgga cagggccttg ccaatccgat cggccagatt tggacagcga 435301 agctgatgct cgaccacttc ggagaggaag aattgggggc gaaaattctg gatgtaatgg 435361 agcaagtgac tgccgacggc atcaaaacac gcgacattgg gggacaaagc acaacggctg 435421 aggtcactga tgaaatctgt tcgcgcttaa gaaagctctg atgaatcagg ccggtggcag 435481 atggctgccc cggcctgtcc atttccttac gaaaatttcc acgaaagtct aaccaagcag 435541 atccaaatgc tgtataataa tttggaattc ttaggaaagc atcgggtgaa ggaagttgaa 435601 tgcaaaaaca atcacgttaa agaaaaaaag aaaaatcaaa acgatcgttg tactcagtat 435661 cattatgatc gcagctctca tttttacgat cagattggtg ttttacaagc cttttcttat 435721 tgaaggatca tcaatggccc caacgcttaa agactcagaa agaattctgg ttgataaagc 435781 agtcaaatgg actggcgggt ttcacagagg agacatcata gtcattcatg acaaaaagag 435841 cggccgctca tttgtcaaac gtttaatcgg tttgcctggt gacagcatta aaatgaaaaa 435901 tgatcagcta tacataaatg ataaaaaggt ggaagaacca tacttaaagg aatataaaca 435961 ggaggtcaaa gagtcgggtg taaccttaac aggtgacttc gaagttgagg ttccttccgg 436021 taaatatttt gtgatgggag ataaccgtct caattcactg gatagcagaa acggaatggg 436081 catgccttct gaggacgata tcatcggtac tgaatctctc gtcttttatc cattcggtga 436141 gatgagacag gcaaaataaa atgcaatgca aaaagaacat ggaacatgac ggcaccgata 436201 ataaagcgcc gtgcacgttt aaaaaaatga tgatgaaacg gtgcggagcc ggctttccgc 436261 cccgtttttt atgatagaaa gcgttttgaa gaaaagggcc ctgttgaaat aaacagaatc 436321 aggattggcg aagccgtgaa gcgcatcgaa ttggtaaatc tcaagatggg tatgctgttt 436381 ttcccgcagt tttttgataa gaagcgctac gtcaaacgac ggctcataat tagggaaaaa 436441 caataggacc gggcaggctg gcatgtgatg aagagagtcg cgtatccggg aaccgtaata 436501 acaaaccgat ccgctcacct caggcatact gctgcatttc catgcgatag tagcccccac 436561 gctgaatcca atcacaaaga tgtgccgtcc ggcgttttgc ctgatcacat tctggatgat 436621 ggtttctccc gttttcagcc tttcgtgttt tgtaaattgt tcgtatgccg ttttttcttc 436681 tttcagtgtg tagacttcat cctcgccgag caggttgggc gtcaacacat catatccagc 436741 cattttgatc agccggccca tctttttcat atggctgttt acaccatata tttcgtgtgc 436801 gagaatgaca agcggttttg ggaacataac ggcctccttt tgtgtttttt ccattatatc 436861 ctatcgtttc actttaggct gagatataat ggtcaaaaaa aggagatata aaatgaactc 436921 attatctttg cctcaccgct atccattttt gtttattgat ggcgtgacgg atagcgagcc 436981 cggcaaacat gcggcagctt ataagctgat tagtgagaac gactggttta tcactgatac 437041 gcaaacagaa atgccgtttt cacttgtgat tgaagcgctt gcgcaaaccg cggcttttac 437101 aggaattaca gatgagaaca gcttgggatt attgtcttcg gtgaagaaag cggaaaagct 437161 gggagaagct gtgcctggtg accggcttga tcttacgttt gaagtcacgc gcaatcggcg 437221 cgggtttgtg ttcggacatg ccaaggcatc agttggagag cagcctgttg ctgaagctga 437281 aatcggcatc tatattgaaa aatgaaaaaa acccttcaca acattttgtg aggggttcta 437341 ttttgtgtcg taatcccgtt cgctttgaga gttatctctt tgctggcgtt tgtgtttttc 437401 atcattcata ttttccttca gctcttcatt aggaatcgga tcggttaagt cgttgtgctc 437461 ggggttttca tttggtttgt tttgctgttt tttttctgtc atgtttgatc acctcaccgt 437521 ttgttttcct cttattcatt ctcctcaaac ataggaaatc gcttttttgt cccgctgggt 437581 ataatgtatt agaatagaga gaagcacaac aaaaagataa agagaggtac atatatgtct 437641 gttcaaagag aagatgtaga tatcaagctg atcgcaattg atatggatgg tacactgctg 437701 aacgacgagc agctgatctc ggatgaaaac cgcaaagcca ttcgtgaagc ggaggataaa 437761 ggtgtgtatg tggtgatcag cacgggccgg acgctgatga cgtgcaggga gctggcggaa 437821 tcgctaaagc tgtcatcctt tctaatcacg gcaaacggca gtgaaatttg ggattcgaat 437881 tttaatttgg tggaacggaa gctgcttcat acggaccata ttcaaatgat gtgggatttg 437941 cggaataagc acaacactaa tttctgggct tctacggtga ataaagtatg gagaggcgag 438001 tttccggaaa acattacgga tcatgaatgg ctcaaattcg gctttgacat cgaggatgac 438061 gatatccgaa acgaagtgct tgaggagctg agaaaaaaca aagagctcga aatcacaaat 438121 tcaagtccga caaacattga agtcaacgcg cttggcatca acaaagctgc agcccttgcc 438181 aaggttacgg aaaaactcgg ctttacaatg gagaatgtga tggcgatggg cgacagcctt 438241 aatgacattg cgatgatcaa agaagcgggt cttggcgtcg caatgggcaa tgcgcaagac 438301 atcgtaaaag aaacggctga ttatatcacg gatacaaata ttgaggatgg tgtcgctaaa 438361 gcgattcgcc attgggtact ataaaaaaag agagtcctaa gatggactct cttttttagt 438421 ttggcaggtt ttattctggg accatggtag gttttctgac aaaagtattt cacaaactga 438481 tatgattcac ttataatgaa ataaagttca aaaattcgga atagtcgttc cgaatttcgg 438541 gacaataaat gacataaagc atatcgtttg ctttggcagg agggattctg tgtttcagat 438601 tgatttaaac tgtgatttag gagaaagctt cggagcctac aagataggcc ttgaccaaga 438661 tattttagag tatgtgacat cagcgaatat cgcatgcgga tttcatgcag gagatcctag 438721 tgttatgcga aaaaccgtcg cgcttgcagc agaaagaggc gtgaaaatgg gtgcgcatcc 438781 gggcttgccg gatttactcg gttttgggcg ccgcaatatg gcgatttctc ctgaggaagc 438841 gtatgatctt gtcgtttatc aaattggcgc gctctctggc tttctaaaag cagagggact 438901 tcacatgcag cacgtcaagc cgcatggcgc tttatacaat atggcggcag tcgatcaaaa 438961 actgtcggat gctatcgcga aagctgtcta taaggttgat cccggcctga ttcttttcgg 439021 tcttgctgag agcgagcttg taaaagcggg agaacggatc ggacttcaga ccgcaaatga 439081 agtgttcgcc gacagaacat accaatcgga cggcacgctg acaccgcgct cccagccgga 439141 cgcactcatt gaaagtgatg atgccgccgt cacccaggtc atcaaaatgg tgaaagaagg 439201 ggcggtcaaa tctcagcaag gacatgatgt gtcattaaaa gcagatacag tctgcattca 439261 tggagatgga gcccatgcgc tgacatttgc gcaaaaaatc agaaaacagc tcaaagcggc 439321 tggaattgaa gtgacagcta tttcagaaca gaggtcaaca taaaggagga acaatagatg 439381 gagcagcaga aaaagacagc aggaaaaaaa gcgggcagct ggtcattgct gatgggcgcc 439441 gcctttttaa tggcgacatc agcaatcgga ccgggtttcc tcacccaaac cgcaacattc 439501 acaaacacac tcgcagcaag cttcggtttt gtcatcttaa tctctattat tttagatatt 439561 ttcgcccaaa ccaatgtgtg gcgcatcatc gcagtttctg gaaaacgagg tcaggaaatt 439621 gcgaatatgg tgcttcccgg actggggtat ttcatcgcca ttctcgtcgt gcttggcgga 439681 ctagctttta atattgggaa tatcggaggg gccgggctgg gacttcaggt gctgttcggc 439741 attacacctg aaacaggcgc tttaatcagt gccgttatcg ccattttgat ttttgtcatc 439801 aaggaagcag gaaaagcgat ggaccgtttt acgcaaatcg cggggttcgt gatgattatt 439861 ttaacggtct acgttgcggc gacgacagct cctccggtcg gacaggcagt cgcaaataca 439921 ttcgtcccgg aacacatcag catatttgcc attgtcaccc tagtgggcgg aaccgtcggc 439981 ggttatatca catttgccgg aggacaccgt ttgcttgatg ccggaattaa aggaaaggaa 440041 tccattccgc aggtgacaaa gagctcggtt gtcggcattt taattacatc tgtcatgcgt 440101 atcgctcttt ttcttgcggt tctaggcgtt gtatcgaaag gcctgcacat cgatgaaagc 440161 aacccggcgg cttctgtctt caagctggct gctggaaatg tcggttataa aattttcgga 440221 ttgatcatgt ggtctgcggc gattacgtct gttattggag cagcctatac atctgtttca 440281 ttttttaaaa ccttttctcc aaaaattgaa aagaattcac gcggtattat tatcggattt 440341 attgtggttt ctacgttagc ttttgtcaca atcggccagc ctgcgaagat cctcgtcctt 440401 gtcggttcac tgaacggctt aattctgccg attgcgctcg gaacgctgct tgttgccgcc 440461 tacaagaaaa acattgtcgg tgattataag catccgcttt ggctgacaag cacaggcgcg 440521 cttgtagtga ttgtaatggc agttatggga atctacacgt tatgtacaca acttcctcaa 440581 ttgtggagct gatataagtg gagcaattaa acaaaatggc gccaaaggat gtacgcgccc 440641 tgatacgaga ggggaaaata aacgggccga ccgcaggcat gtccggcggc tacgcccaag 440701 cgaatcttgt ggttttgaaa aaggaccttg cgtttgattt tctgctgttt tgccagcgaa 440761 atcaaaagcc ctgccccgtg ctggatgtga ctgaagcagg ttcgcctgtg ccgtctctgg 440821 ctgcgccgga tgctgatatc agaacggact ttccgaaata ccgtatttac aggcacggta 440881 tcctaacgga agaagtatct gatattacgc catactggga ggacgatttt gtcggctttc 440941 tgatcggatg cagtttctcc tttgaacagg cactgatcaa taatgggata gctgtccggc 441001 atattgatga ggggacaaac gtctcaatgt ataaaacgaa tatcgattgt gttccggcgg 441061 gggcgtttca cggacagatg gttgtcagca tgaggccggt tcctgaacgg ctggctgtac 441121 gtgctgcaca agtgacctcg cgttttccgg ctgtgcacgg agggccgatc catattggca 441181 atccgggagc aatcgggatt cgcgatctcg ggaaaccgga tttcggagat gccgtttcca 441241 ttcgtgacgg cgaggttcct gttttttggg catgcggagt gaccccgcaa gccgtggcta 441301 tgaatgtaaa gcctgaaatg gtcatcacac atgcgccggg gcatatgctc atcacagata 441361 ttcgagacga gtcgcttgcg gtgctgtagc ctctcgtcat cctgatgaac gagaattaaa 441421 agaggtgaga aagatgactg tacgatatca aatcgaacag ctcggtgatt ctgcaatgat 441481 gatccgattc ggagaagaaa tcaatgaaca ggtcaacggc attgtccatg cagcggccgc 441541 ttatatagaa gaacagccat ttccgggatt cattgaatgt atcccggctt ttacaagtct 441601 aaccgtattt tatgatatgt atgaagtgta caagcatttg cctcaaggca taagctcacc 441661 ttttgagagt gtcaagcgcg atgtcgaaga gcggctggca gaaatagccg aagactatga 441721 ggtcaaccgc cgtattgtag aaattcccgt ttgctatggc ggtgaattcg gtccggattt 441781 agaagaggtg gcgaagatca atcaactgtc accggaggaa gtaatcgaca ttcatacaaa 441841 cggtgaatat gtggtgtata tgcttggctt cgcgcccggt tttccttttc taggcgggat 441901 gtcaaaacgc attgcagctc cgagaaaatc atcgccaaga ccgtcgattc ccgcaggttc 441961 ggtcggtatt gcgggattgc agacaggcgt ttatccgatt tcaacgccgg gcggctggca 442021 gctgatcggc aaaacgccgc tggctctttt ccggccgcag gaaaacccgc cgacattgct 442081 gcgggcggga gatattgtga aattcgttcg catctcagaa aaagactatc acgcctataa 442141 ggaggagtcc aattgagcat gaaagtatta aagcccggac tgctcacaac ggttcaggat 442201 ataggcagaa cgggttacca aaaatacggc gttctggcca gcggcgctat ggacacggtt 442261 tcactgcgca ttgccaatct gttgatagga aacggcgaaa atgaagcagg tctcgaaata 442321 acgatgatgg ggcccggtcc gtcgtttcat ttttcaaaac agacactgat tgctgtgaca 442381 ggggcggact tcacgctgcg tattaatgac gaggaagcgc ctttatggaa gcctgtgctc 442441 atcaaggaaa acagcacggt cagctttggc ccctgcaaac tcggcagccg tgcttatttg 442501 gcggcagctg gcggcattga ggtgcctgcc gtcatggaaa gtaaaagcac atacgtcaga 442561 ggaagcattg gcggacttca tggcagagcg cttcaaaaag aagatgaact gaacattgga 442621 gagatgtcag ctctttcgca aaccatcctt tctcgcttaa gttcgcagct tggaaaacag 442681 ggatttgcag caccgaagtg gtcagtcagc cgcggcagat ttctgccatt gaagaagaat 442741 cccgtcattc gggtgctgga aggaaagcaa tttgcctttt tcacagaaga atcaaaaacg 442801 cgtttttatg aagaagcatt tcgtgtcacg ccgcagtccg accgtatggg ctacaggctc 442861 aaaggagaac cgctcgaact gaaggccccg cttgagatgg tgtcggaagc ggtttcattc 442921 ggaacagttc aggtgccgcc tgacggcaac ccgattatcc tgcttgcaga ccggcagacg 442981 actggcggct atccgaggat cgcgcacatc atatccgctg atcttccgat tgtttcccaa 443041 atcatgccgg gcgagcacgt tcagtttgag cctgtgtccc tccaggaggc agaagcgctt 443101 gcggtagaac gggaacagca tataaaagaa ctgaaaacga gaatgaagat ggaatggctg 443161 acatagcaaa ggggatgaat gatgcagaat aaaaataaaa ccgtagtcaa atctatggcg 443221 ctgcttaatt tgtttttgca taaaccaagc ctaaccttaa gtgaactggt gtcgctgacg 443281 ggaatgccga agacctctgt tcaccggatg gtcagctcct tggaggaaat ggggttcctc 443341 agtcgggatg cgtccggcgc ttattcgctg ggattggtgt ttttggaatt cggacagctt 443401 gtcgctgaca ggctggatat cagaaaaata gcgaaaccgg tgatggaaga gctgtgccgg 443461 gaagtggatg aggccgtgca gttgatcatg agggacggca atgaagcgat atacgttgag 443521 aaaatagaag ggacacagac tgtgcggctg tatacggcga tcggcaggcg ttccccccta 443581 tacgcgggag cgtgcgccag aagcattctg tcctttcttc cccgtgaaga aatcgaagca 443641 tacatcaaac aaaccgagct catttcgatt ggctccggaa cgattaccga tcccgaaaaa 443701 ctgcttcagg agattgatgc ctctgtgcaa aatggctata ctgtcagcta ttcagagctc 443761 gaaaactata cggcggcgat cggcgccccg atctttaacc atgagcgcca ggtggcagcc 443821 ggcattagca ttgcaggctt tgaagcgaga tttacagaag acaggctgcc ctatttaaca 443881 gaaaaggtga aggacgccgc tttacagatt tcaagaaaaa taggatatac ataagtagcc 443941 aatcttttct ctgctgcgta cattaacgta tcgacgttca agagtggagg aaagaacatg 444001 gtgcttcgat atacagctct gggcgattcc ttgacgacag ggagaggctc cgggctgttt 444061 tcacccggct tcgtccagcg ttttggggac atgatggaag ctgacttgaa aacaagaacg 444121 gcaataaaca tatttgccag atcaggtctg aatacagaag agattttggg actcctgtca 444181 tatccctatg tgcaaaaatg tattcgagat gctgatatga taacgatcac agggtgcgga 444241 aacgatctca tcgattcggt cttagcctac caaacctcta aggatgaaac gattttcagc 444301 cgtgtatccg cccattgcca tgagaatttt gaaaagatga ttgccaaagt cgccgagatt 444361 aaaggagaaa atccttcccc gtacgccatt cgtgtgttca acttatacaa tccgtttccc 444421 gaaattgata tcgccggcaa atggatcact tcgtttaatt cacatttaga aacacttgca 444481 tcagcacccc atgtcaaaat cgcggatgcc tatagcatct tcaaaggcaa agaacaggaa 444541 tatctgtcct ttgacggtgt ccatccgaac agcaaaggct atcaagcgat ggctgaagcc 444601 gttcacaagc taggctataa agaattatca gtttcataga aaacgcgcct catgacaggc 444661 gcgtttttta tgtgtgatcg aaatattaaa agaaacttaa aattctctgt cttctgttct 444721 acagacaaac aaagtgcgct agaataatgg agggcgtagg caaatatagc cataacgttc 444781 aatatttcgt atataaggaa ggatggtcct tttgtttcgg atttttaaaa tgtcttttgc 444841 ggttatcatt attatactgg cgcttattgc ttttaactat acggaacaca cctctgtaat 444901 ccaatcggtc atgctcgtct ttcttggtgc ggtcatgttt atgcaggggc ttgaagagcg 444961 caaaaaagaa aatgacggct caggcgcttt taatatttat accgccgttt ttgtatggtc 445021 tgtctccctt atcggtttta cacttcatat tatataaatc tattacacat cctgaaaatg 445081 ctcgaccgtc gggaacgggg tatagaaccg atgaagcaag gctttccact cttgatactc 445141 tgaagaaccg cgaaagcctt ccgtatggtc ctcaagtgtt tcccactcca caagaagcag 445201 atatttatgc gtttcctcca tgcattttga taacgagtga gtgatatagc ccttcatgcc 445261 ggaaataatc ggcgcagctt gccggaatgc atcctcaaac tcttgttcaa ggccttcttt 445321 aatgtgaagc attgctgcct ctctgaccat gctatccctt ctttctgtct tttcaaatag 445381 tctacagcaa acgataggag atttctgcaa aatcggtgaa cttttccttc attttcaaaa 445441 aaatcttgca cgcaccaatt caattaagag aaaataacaa gtggaaggca ggggaaagtc 445501 atgttaaaaa agtgtattct actagtattt ctatgcgtcg gattgattgg gttaatcgga 445561 tgctccaaaa cagattcacc agaggatcgc atggaagcat tcgtgaaaca gtggaacgat 445621 cagcaattcg atgacatgta tcaaagcctg actaaagatg tcaaaaaaga aatctccaaa 445681 aaagatttcg tcaacaggta taaagccatc tatgagcagg ccggcgtaaa aaatttgaaa 445741 gtcactgcgg gagaagtaga taaggacgat caagacaaca agacgatgaa acatatcccg 445801 tataaagtca gcatgaacac aaatgccggc aaagtcagct tcaagaatac tgctgtgctg 445861 aaattagaaa aaacagatga cgaggagtca tggaatatag attgggaccc atcgtttatt 445921 ttcaagcagc tggctgacga caaaaccgtg caaattatga gcattgaacc gaaacgaggc 445981 caaatttacg ataaaaatgg aaaaggctta gccgtcaata cagatgttcc ggaaattgga 446041 attgttcccg gagagcttgg cgataaaaaa gagaaagtca taaaagaact cgccaaaaaa 446101 cttgatttga ctgaagacga catcaagaaa aagctggatc aaggctgggt aaaagacgat 446161 tcgtttgtgc cgctcaaaaa ggtcaagcct gaccaggaga aattagtttc tgaagcgacg 446221 tcattacaag gcgtaacaag aacgaatgtc agctcccgct actatccgta tggcgaaaag 446281 acagcccatt tgacaggcta tgtccgcgcc attacagcgg aagaactgaa gaaaaagaaa 446341 gaaggaacgt acagcgatac gtctaacatc ggtatcgccg gacttgaaaa tgtgtatgaa 446401 gacaagctaa gaggcacaac tggctggaaa atctacgtgc cgcaaaccgg ggaagtcatc 446461 gctgaaaaga aagcaaagga cggcgaggat cttcacctca caattgatat caaaacgcaa 446521 atgaagctgt atgatgaact gaaggatgac agcggggcgg cagtcgcgct gcagccgaag 446581 acaggcgaaa cactcgccct tgtcagcgcg ccttcctacg atccaaacgg atttattttc 446641 ggctggagcg ataaggaatg gaaaaagcta aacaaagata aaaacaatcc gttttcagcg 446701 aaattcaata agacatacgc gccaggttct accattaaac cgattgcggc tgctattgga 446761 atcaaaaacg gcacccttaa agccgatgag aagaaaacaa tcaaaggcaa ggagtggcaa 446821 aaagattcaa gctggggcgg ctattcagtg acacgtgtgt ctgagagact tcaacaagtc 446881 gatttggaaa acgcccttat tacgtcagac aatatttatt ttgcccagaa tgcgcttgat 446941 atgggagcgg acacctttac aaaaggcttg aagacattcg gtttttcaga ggacgttccg 447001 tacgaattcc cgatccagaa atcgtctatt gcaaatgaca agcttgattc agacattttg 447061 cttgcggata caggctacgg acaagggcaa atgcaaatgt ctccgcttca cttggcaact 447121 gcttacacgc catttgttga caatggagac cttgtcaaac cgacgctgat caaaaaagat 447181 tcacaaacag ctgatgtttg gcacaagcaa gtggtcacga aggaaggagc ggcagacatt 447241 acaaaaggtc tgaaaggcgt tgtggaagat gagcgcggat cagcgtatca gcctgtcgtg 447301 aaaggaatca cagtggctgg aaaaacagga acagccgagc tgaaaacatc aaaagatgat 447361 aaagacggca cggaaaatgg ctggtttgtc ggctacgatt acgaaaacaa agacctgctt 447421 gtcgccatga tgatccaaaa tgtgcaggac cgcggcggca gccactatgt cgttgagaaa 447481 gcgaaaaagc aatttcaatc gaattaaaat gtctttttaa aaggagcgaa aggaaaaagg 447541 ggatctgagg ccgaatgaac tagtaagggg gcaaaacccg gtttatacaa agaaaagagg 447601 gattttgcat gcagcgtatt caattggcgg aggatcttca attttcaaga gtcatacacg 447661 ggctttggcg gctgaatgaa tggaactatt cagatgctga acttctaagc ctcattgaat 447721 ggtgtatcga tcacggcatc acgacctttg atcatgcgga tatttatgga ggctatacgt 447781 gcgaaaagct gtttggaaac gcccttgccc tttcgcctgg attaagagaa aacatagagt 447841 tggtcacaaa atgcggtatc gttcttgaat cgcctgaacg gcccgctcac agatcgcatc 447901 attataacac aagcaaatcg catattttgg catccgttga gcaatcgctt atgaacctta 447961 ggacggatta tatcgatatg cttttgattc acagaccgga cccgctcatg gatccggagg 448021 gggtagcaga ggcgtttcag gccttgaaat gctctggcaa ggtcaggtac tttggcgttt 448081 caaattttaa agatcaccag tatcggatgc tggaatcata tttgcctgag aagctcgtaa 448141 ccaaccagat tgagctttcc gcatacgaat tagaaaatat gctcgacggc actttgaacc 448201 tgtgccagga aaaacggatt ccgccgatgg cttggtcgcc tctggcaggc ggcaaagtat 448261 tcactgaaaa cacggataaa gaccgacgtg tccgtacggc gcttgaatcc gtccaagggg 448321 aaatcggcgc cgcttcattg gacgaggtga tgtacgcatg gctgtatacg catccggccg 448381 gcatcatgcc gattgtcgga agcggaaagc gcgagcggat ttccgccgcg ataaatgcgt 448441 tgtcatacaa gcttgaccag gatcaatggt tccgcatttt tacagccgta cagggttacg 448501 atattccata aaaagcatca gtttaccagc tgatgctttt tcaatattgt cacaccgctt 448561 agtgccaaat taccatttat aagtgattga ttctttcttg aaagcgtttt atattaaaag 448621 gaaacctctc tatatcctct actgcatctc cttgcgactt catccgcaca tcaagattgg 448681 ctaggaggtc ttttttatgt atatgactgc cagagaacaa aagctgttaa agcacttatt 448741 attacaaaac agatatataa ccgtaactga gcttgctgag ctgatgcaag tcagcacgag 448801 aaccattcac agggaactca aatcaattaa accgctgatg gaaaccgtgg ggcttacgtt 448861 agataaacag cccggtaaag ggttgaaagc agtgggaagt cccgagggta aacaaaagct 448921 gcttactgat ttatcatatg aacagcatga atacagcgcc gacgaacgga aactgctcat 448981 tctttgttcg ttattagagt ctcaggagcc cgtcaaactg tacacgcttg ctcatgatct 449041 ccaggtgacg aatgccacgg tcagctatga cttagatgag ctcgagaagt ggatttctcc 449101 ctttggactg acactgatcc gcaaaagagg ttttggcatc cagctcatag ggccggagaa 449161 tgcgaaacgg aaaattgtcg gcaacttgat tgtgaaccgt ctcgacatcc aaatgttttt 449221 ggaagcggtt gaattaaaca tcaaaggaaa aaccgattct tcagagaaaa tgttcggggt 449281 tgtcagcaaa ggtgagctgt taaaaatgga gcgcatctta tttcagctca aagaaaaaat 449341 cgctttttca ttgtccgaca gctcctatat agcgctcgtc gtccatctga cgtatgcgat 449401 cgaacgaatt aagcttgggg aaactatcac catggagcaa aatgagcttg aggaactgat 449461 gaatgcgaag gaatacagct ccgctcttga aatcgcgggc gagcttgaac gtgccttcgg 449521 cgtgacgatt ccagaggcgg aggtcggcta tattacaatc catcttcgaa gcgccaatcg 449581 aaaatacaaa acagaataca aagcgcagga aattgagctg gaaacagccc tgcaaacaaa 449641 gcggctcatt gcttttattt cagacaaaat cagaatggat ctgacgaaaa actactcttt 449701 atatgaaggc ttgattgccc atttggagcc ggccgtcagc cgcataaaag aaaatattga 449761 gatatacaat ccgatgaagg aacagatcaa gcgcgattat tttctgcttt atatggcgat 449821 cgaagaaggt gtcgaaaagt attttccggg catgtccttt tctgatgatg aaatcgcttt 449881 tatcgttctt cactttggct cggctcttga aatcaaaaaa gaagaagcaa aagtgaaagc 449941 gcttgtcgtc tgctcaagcg ggatcggctc ctcgaaaatg cttgcctcca gactgaaaaa 450001 agagctgccg gaaattgaat cgtttgatat gtcatctctg atcgagctaa aggggaagga 450061 tgttcaagcc tatgatatga ttgtgtccac tgtaccgatt ccttatgaaa acattgatta 450121 catcatggtc agcccactat taaatgagga agacgcaaac caggtcaagc agtatatcaa 450181 gcggaagatt ccccttattc ttaacaaaaa aagaagctcg aaggaagagg cgcagcaagc 450241 tgatgtacct gacatgctgg aggcggcgga aagcataggg cggtatatgg aagttatcca 450301 agatgttctg cgccatttta cgctagctca actcaaaaca aacccggacc atagcatgct 450361 tctgctagag ctttttcaac agctgaagaa ggatggcctg atccgtgatc cggaaaaagc 450421 cgcggtttgc ctggctgagc gggagaaaca agggggattg ggaatccccg gaacaaacat 450481 ggcgctttat catctcaaaa atgatgaaat cgtcctgcct tttttcaaaa tgtttgatct 450541 cagcaccccc tatgaagtgg atggcatgga cggaaatacc ctcaggatga cacgcattct 450601 cgtcatgatg gcgcctggct cattatctgc tgaaggctcg gagattttaa gcgcgatcag 450661 ctcggcaatt atcgagagcg gagaaagcat ggcggggttt caggaagaag gaggacaaga 450721 attgtatcag cggttaaacc gcatattttt cacatggatg aaagaaaaaa acatactgta 450781 aacctgcatg gcacacgtca aaaatttggc gtgtgttttt ctgtggatgg ggaacaaaat 450841 aagaaaatgt gggactattt tatcattcag tattggaata attccaaaat gaaatagttt 450901 tacaagttat cttttttggg ttaaaatggg tgaggtaagg aagaaaatct aacaaattat 450961 tgaagattca agagaatata ggagatgacg atatggaaac attacagcat ctgattctgc 451021 atgacatgcc gaatagcgaa gaaatagagg ctgtaaaaag cggagaccat acactgacat 451081 ataaaggtta ccgtaaacgg attaatcagc tggcgaatgc catgcttcaa aaaggaattc 451141 aaaagggcga ccgtgttgca ttgctttgca aaaacggcca tcccgcctca actgttatgt 451201 tcgccgcact tgaaataggt gctgttgtcg tacctgtcag ctggcagctg aaaccatatg 451261 aaatgacagg cattttaaaa gcaagtgaac caaaagcgat gttttacgga gcggagttta 451321 aagagatact ggatgaagtt cttcctgaat tgtcctcact gtgtgtaaca atggaaacag 451381 gaacagctta cgaaacatct gctgaatttg aagcgctgtt tgcaggtcct gatcatttgc 451441 cagagacgga aatggtttca cctgatgata cagcacttct gatgtttaca tctggaacaa 451501 cgggaaaccc gaaaagatgc atgattacac atggcggcat atacagatac gttaaaaaat 451561 ccaacagctc aatagcacgt atgaagggcc ttcgttttct cgcgtgccat ccgatttatc 451621 atacgagtgc gctcatttgc atcatgcttg gaacgtttgc agaaacaaca tttgtgttta 451681 caaaggatca agatcctgtt cacatgctga aggtcattga agaagagaag attcagaccg 451741 tgatggctct tcctgtgttc tacacgtatt tgcttgaggc gtgggaaaag caccaaactg 451801 acttatcttc gcttgttatt ttaatgacag gcggaacaaa agtgccgagc agcctaataa 451861 gccgctatct tgatattggc attccgcttg cgcatggcta tggaagtact gaggcttggg 451921 gcatcagcac atggacgcct gatatgggaa tggataaagc ggcatctgca ggaaaacctg 451981 tggcaggtgt taaagtcaaa gtggaagatc ctctgaccgg agaagaactt cctcaaggag 452041 aaatcggcga aatcgttgtt catactccat tcttatttaa aggctatgaa gacaatcctg 452101 aagcaacagc gaaagtgctg caaaatggat ggtttagaac cggagattca ggatatgtag 452161 atgaagatgg ctttattttc atcacgggac gctacaagga tgtcattatt tacggaggcg 452221 ataacgtcta tcctgatcag gttgaagaag ttatccagca gatcccggga atccttgaaa 452281 cggctgtggt cggtattcct gacccgcttt acggtgaaaa accgaaagct tttatcgtga 452341 aaaatggcgg ccagcgcatc acggaagagg atgtcatcgc attttgtaaa gaacgcctgt 452401 ccgcttacaa aatacctgaa gttgaatttg ttaacgaact gccgaaaaac aaccttggca 452461 aggtgaaaaa agacgtcctg cgcaatcagg ctgtacattc ataaaagaag aagcccgtcc 452521 actttatgtg gcgggcttct ttgcagttgc acagacggaa agctcaggct taatgttctt 452581 aaattgtata tcaatgtctt cgaagccggc tgctttaaag tcagcaatca tctgtcttcc 452641 aaatgatttg gttttctcag gactggcatc cgcttcccgc ggctgcatcg taatggctgc 452701 tttgccgcct ggctttaatg cccgataaat ctgttttatg ccttttgttt ggtcattcca 452761 aatggtgtag ttgttaacgg aaatcacttt atcataaaac gaggcgggga gaggaaatgt 452821 ctcgatgctt ccttgtatca ggcgtacgcc ctttggtttc actctgcggg cggccagctt 452881 cagcatggcc tctgatacat caatcccatg aagatgaaca tccttctcgc gtttcagcat 452941 ctgctgcatg cagtatcccg ggccaaaccc gacttctaaa atgctgtccc cgcgcgtgat 453001 acccagctga ttgattgtcc actgattcag tgtttgattt tcagcagcca tgatgtaccc 453061 ggcaatcatg ccgatgacgc cctttggcct gctgaatctt ctagaaagca tgttaatcat 453121 tcagcaacca accccctttt tgagttaatt tcctctcagc gttccatgtg aaacattttt 453181 ctgataaagc aatgcgaagg tgccaagcca tgtttatcca aagagtgtgt gaggtacaca 453241 acaaatagac atgaaaacaa aggaggagaa tcatcatggc aaattatcca aaagaactgc 453301 cggcacaaac tcaaagtcgc cagccgggaa ttgaaagcga aatgaatcca agtccggtgt 453361 atgagtacga ggattataaa ggagcagaca aattaaaagg aaaagtagct cttattacag 453421 gcggcgacag cgggatcgga cgcgcggttt ccgtcgctta cgcaaaggaa ggcgcagaca 453481 tcgccattgt gtataaggat gagcatgaag acgctgagga gacgaagaaa cgtgttgaac 453541 aagaaggcgt aaaatgcctg ctgattgctg gtgacgtagg tgaagaggaa ttctgcaatg 453601 aagcggttga aaaaacggtc aaggaactag gcggccttga catccttgtc aacaatgcag 453661 gtgaacagca cccgaaggaa agcatcaaag atattacgag cgaacagctt caccgcacat 453721 tcaaaacaaa tttttattct caattttatt tgactaaaaa agcaattgat tacctgaaac 453781 cgggcagcgc catcatcaat acgacatcca tcaacccgta cgtagggaac ccgacactga 453841 ttgattatac agcgacaaaa ggggcgatca atgcctttac aagaacaatg gcgcaggcgc 453901 ttgtcaaaga cggcatccgt gtaaatgcag tcgcgccggg tccaatttgg acgccactaa 453961 tcccagctac gttccctgaa gaaacagttg ctcaatttgg gcaagatacg ccgatgggcc 454021 gtcctggaca gcctgttgag cacgtcggct gttatgtgct tctggcatca gatgagtcct 454081 cttacatgac aggtcagacc ctgcatgtca acggcggaaa ctttgtgacg acataagagg 454141 gagtgagaca tatgggcatc acgaaagaag aagtgaacag ctactatcaa aaagcaggga 454201 ttgtattaac ggacgaggaa gtagaccaaa tccagctgat ggattacggc ttaggaaaag 454261 aaagaaaagt cgggctccag ctcttcgtct acgtcaatac agaccgttat tgttcaaagg 454321 aattggtgct gtttccggga cagacttgcc cggaacaccg ccatccaccg gtcgacggcc 454381 aggaaggcaa gcaggagacc ttccgctgcc gctacggaaa agtgtatctt tacgtagaag 454441 gagaaaaaac gccgcttcca aaagttctcc ctcctcagga agacagagaa cactatacgg 454501 tctggcacga aattgagcta gaaccgggcg ggcaatacac gattccacca aacacaaagc 454561 attggttcca ggccggggaa gaaggtgccg tcgtgacgga aatgtcatcg acgagcacgg 454621 ataaacatga tatctttacc gatccaagaa tataaggatg ggcttaacag cccatccttt 454681 ttgtattgaa aaaaacagaa tcatcgctat aatgggtaaa aaaggaaaga gggcgaggca 454741 atgttcactt gcaaggtaaa tgagcacatc accatccgat tattggagcc gaaggatgcg 454801 gagcggctgg ccgaactcat tatccaaaat cagcagcggc ttggcaagtg gctgtttttt 454861 gcggaaaatc caagcagcgc tgacacgtac cgagaaacaa tcattccaga ttggcggcgc 454921 cagtatgccg acctgaacgg cattgaggcg ggtctccttt atgacggcag cctatgcggc 454981 atgatcagcc tgcataacct tgatcaagtg aatcgtaagg cggaaatcgg atattggatt 455041 gccaaagaat ttgaagggaa aggcattatt acagctgcct gccgaaaact cattacgtat 455101 gcttttgaag agcttgagct gaatcgtgtg gcgatctgtg cggctgtcgg aaacgaaaaa 455161 agcagagcgg ttccggagcg gatcgggttt ctagaggaag gaaaggcacg ggatggctta 455221 tacgtaaacg gcatgcatca cgacctcgtc tactacagtc tgttaaagcg tgaatgggaa 455281 ggcgaaaaat aaagagcaca ctttcttgtt taaatcttcc ccggatgtgg aaaagtaaca 455341 gcggagacgt taaaaaggag tgattcgaga tgaatcagca agacattaaa caaaaagtgc 455401 ttgatgttct agatcaccat aaagtaggtt cgctcgcaac agttcaaaag ggcaaaccgc 455461 attcccgcta catgactttt ttccatgacg ggctgacgat ttacacaccg acaagcaagg 455521 aaactcataa agcggaagaa attgagaaca accccaatgt ccacatttta ttaggctatg 455581 attgtgaagg ttttggcgac gcatatgtcg aagttgccgg aaaagcaaag atcaacaatt 455641 cggcagaact caaggacaaa atatggagtt ccaaattaga gcgctggttt gacggcaagg 455701 atgatccgaa tctggtgatt cttgaaattg aaccggagga tatcagatta atgaatgccg 455761 gggagaaaac accggtctca ctcgaactat aaaaaatttg tgttttcagg ggcgatatgt 455821 tattatgaat agctagtaag aaaaataagc aaataaaaaa gaaagtaaac ttcttttttc 455881 tgttttgaga gagaagctta ccgcttccca agcagcataa ccagctgccc ttattctttt 455941 ccttcataac aaatcgcccc taacgatgag atggaaaaaa gacttttttg ttttacaatt 456001 cacaccggcg cggcttcgga gccgcagtga cgattgagag gtagggcttt cgttgtcttg 456061 tgttcaagaa atttccatgg tgtttacttt ccagaatgat tcttcggaac aatgctttat 456121 gaatctaacc cgcctgactt ggcggatgat ataatcttta tttgcgtata gaaaagaata 456181 agacaaaccg cccggcgtac gccggacggt ttttttattg caaaaaacac atcgtactga 456241 aacctccttg tcttctttcc agtcttatct ctaggatgaa attggaggaa gaataacgtg 456301 catgtcatta caacacaagt actttttatt ttttgttttt tattgctgat tcactcgata 456361 gaaaccttag cctatgcgac aaggctttcc ggagctcgcg ttggatttat tgcgtccgcg 456421 ctttctctgt ttaatgtcat ggtcatcgta tccagaatgt cgaatatggt gcagcagccc 456481 tttactgggc atttaattga tgatgctgga aaaaacgcac tggcgattgt aggggagcag 456541 ttccgctttt taattttcgg atcgacagtc ggcaccattt tgggcattat cctgctcccg 456601 tcttttgtcg ctcttttttc acgggcgatt attcacttgg cgggcggcgg cggctccgtt 456661 tttcaagtat tccgaaaggg attctcgaaa caaggattca aaaatgccct ttcctatttg 456721 cgtctgccgt ccatttcata tgtaaaagga tttcatatgc gcttgattcc gaagcgtttg 456781 tttgtcatca acatgctgat cacatcgatt tatacgattg gtgtgctttc ggctttatac 456841 gcaggccttt tggcgccgga gcgcagcacg acagccgtca tggcttcggg tttgatcaac 456901 ggaattgcaa cgatgctgct ggctattttt gttgatccta aggtatccgt tcttgctgat 456961 gatgtggcaa aaggaaaacg aagctatatc tatttaaaat ggacctctgt cacaatggtc 457021 acatcaaggg tggcgggcac actcctcgcc cagctcatgt ttattcccgg ggcctactat 457081 atcgcgtggc tgacaaagtg gttttaataa gaaaggctgg atcataaaga tccagccttt 457141 ttgcgcttcc ttatttatag ttccttaatc cgcggtcgta caaaaaattt ccgaatggga 457201 cgaaagcggc gatgaagccg gcagctgacc atttcagcgg ccatttgaca gagaaggttg 457261 cataagccaa gacaagcaaa tacaaaatga acaacccgcc gtgaaccgaa ccgacaattg 457321 tcaccgcaag cggaaggcct gcccaatatt taagcggcat agcgatgaac aacaggatta 457381 agagtgacat tccttcaata aaacccatcg tgcgaagtct tccgatcggc gtgtgcagca 457441 taaatcgccc tccttgtgga cacgttttca ttttatacta taaacaatcc gggggggcat 457501 atgacagctt tcaaaaaatg ttcggaaaac attcattttt acatgccttt tctagggaac 457561 tgtacttgtc atttacaaaa atacccgaga taatgtgtac aaaatcaaaa aagaaggatg 457621 ttgaaatgaa acttgaccag attgatctga atatcattga ggagctgaag aaggacagcc 457681 gtttgtcgat gagggaatta ggcagaaaaa ttaagctgtc gcctccatct gtaacagaac 457741 gggtaagaca gcttgaatcg tttggcatca tcaagcaata cacgctggag gtcgaccaga 457801 aaaaactggg gcttcccgtt tcctgcattg tggaagcaac cgttaaaaac gcggattatg 457861 agcggttcaa aagctatatt caaacattgc cgaatattga attttgctac cggattgcgg 457921 gtgcagcctg ctatatgctg aaaatcaatg ccgaaagcct cgaagcggta gaagatttca 457981 ttaacaaaac atcgccctac gcgcaaaccg tcactcacgt cattttctca gaaattgaca 458041 cgaaaaacgg gcgcggttag agagtgccgc gcgaagtctg ttataataac aggatgagcg 458101 tgaaagaaag agaagtgatc aagcatgtca aaaacagttg tattagctga aaaaccttca 458161 gtcggccggg atttagcccg ggtactgaag tgccataaaa aaggaaacgg ttatctcgaa 458221 ggcgatcaat atattgtgac ttgggcttta ggccatttgg tgacgcttgc tgatccggaa 458281 ggctacggaa aagaatttca atcatggcgc ctagaggatc tgccgattat cccagaaccc 458341 ttgaagcttg tggtgataaa aaaaaccgga aagcagttca atgcagtcaa atcccagctt 458401 acccgtaaag acgtcaatca gattgtcatc gcgactgacg caggccggga aggtgagctt 458461 gttgcgcgct ggatcattga gaaagcgaat gtccgaaaac caatcaagcg gctgtggatt 458521 tcatctgtga cggataaagc gatcaaggaa ggttttcaaa agctgcgcag cggcaaagaa 458581 tatgaaaacc tgtaccattc tgccgtcgcc agagcggaag cggattggat tgtggggatc 458641 aacgccaccc gtgcacttac cacaaaattc aatgcccagc tctcatgcgg gcgtgtgcag 458701 actccgacgc ttgccatgat tgcaaagcgc gaggcagaca ttcaggcgtt tacgcccgtt 458761 ccgtattacg gcatacgtgc tgcagtcgac ggcatgacgc tgacgtggca ggataagaaa 458821 tcaaagcaga cgagaacgtt caatcaagat gtaacaagcc gtttgctaaa aaatctccaa 458881 ggaaagcaag cggtcgtagc tgagctgaaa aaaacagcga aaaaaagctt tgcgcctgcg 458941 ctttatgatt taacggagct ccagcgtgac gcccacaagc gcttcggttt ttctgccaaa 459001 gaaacgcttt ctgtcctgca gaagctatat gagcagcata agctcgtcac atatccgcgg 459061 acggactcta gatttttatc cagtgacatc gtcccgacgt taaaagaccg tctggaaggc 459121 atggaagtaa aaccgtatgc ccaatatgtc agccaaatta aaaaacgcgg cattaaatct 459181 cataaaggat atgtcaatga cgcgaaggtg tcagaccacc acgcgattat cccgaccgaa 459241 gagccgctcg ttctcagcag tctgagtgat aaagaacgaa agctgtatga cctgattgcg 459301 aaacgtttcc tggctgtatt aatgcctgca ttcgaatatg aggaaacaaa ggtcatcgca 459361 gaaatcggcg gagaaacctt tacggcgaaa ggcaaaaccg tgcagtcgca agggtggaaa 459421 gccgtttatg atatggcgga agaggatgat gagcaggagg atgacagaga tcagacactt 459481 cctgcgcttc aaaaaggcga cacacttgcc gtccgcacgt taacggaaac aagcggccaa 459541 acgaagccgc ctgcccgctt taatgaaggg accttgctgt cagcgatgga aaacccaagc 459601 gcgtttatgc agggagaaga aaaaggcctc gtcaaaacgc ttggagaaac aggcggcctc 459661 ggcacggtgg caacgcgtgc cgacattatt gaaaaactgt tcaacagctt tttaatcgag 459721 aaaaaaggcc aagatatttt tatcacatct aaaggaaaac agctcctgca gcttgttccg 459781 gaggatctga aatcaccggc cttaacagca gaatgggagc aaaagctgtc tgcgatcgcg 459841 gccggcaaat tgaaatcggc tgtttttatt aaagatatga aggcttacgc tcaccaaacg 459901 gtaaaagaaa tcaaaaacag cagccaaacc ttccgacatg acaacattac gggaacggca 459961 tgtccggaat gcggcaaaat gatgctgaaa gtaaacggca aacgcgggac gatgctcgtg 460021 tgccaagatc gtgaatgcgg aagcagaaaa acgattgccc gaaaaacaaa cgcacgctgc 460081 ccaaattgcc ataaaagaat ggagcttcgc ggccaaggcg agggccaaac ctttgcgtgt 460141 gtgtgcggtc accgtgaaaa gctctctgta tttgaaaaac gaaaaaacaa agacaaagcg 460201 cgtgctacca aacgggacgt atcctcttat atgaaaaaac aaaataaaga tgagccgatt 460261 aacaacgcgc tggcagaaca gctgaaaaaa ctcggtttgg ataaataata aaaaaacctg 460321 tgcctatcgc acaggttttt tattggactt aggtcctgtt ttcttaatgt tcaaaaaggg 460381 aaaaaaaagc tagcaatctg catttttttt cttttatagt aaatgtactt tgtaacatgg 460441 cagtcatatt ttcgtctata actatttgtg agcgtctgat ttgcttcagg cgacaaaggg 460501 ggatttgcct gtgaggcatg tactaattgc tgtcatctta ttcttcttat ctatcggact 460561 ttccgcaggg tgtgctgaag ctggaaacaa gacccaaaat cagtcggcga cagaagtgaa 460621 tgccagcccg ctccagccgg cggaatattt catctatcac aatttaatga atgacaaagg 460681 gctgatcaaa accgattttt cagaccagcc ttcttacttg tcggaatctc tcggactgtg 460741 gatggagttt ctgctcagca aaaatgacgc accacatttc caggatcaat atcagcatct 460801 gactgattca tttctgatga gcaatcactt ggtgacgtgg aagattcaaa atggccaagc 460861 gagcgggacg aatgcgctga tagatgatat gagaattatg ctgtctcttg accaagccgc 460921 cgcaaaatgg ggccgcagcg actacgcgca aacggctagg gatatcggca cgtctttgaa 460981 gacatacaat atgaacaacg ggttttttac agacttttac gactcacagg ccgcttcaaa 461041 ggatgtgacg ctttcatacg tcatgcctga tgccttagct gtcttaaaga agaatggaat 461101 catagacgaa gaaacagaac agcggaatgc caatgttctc tattcagctc ctttaaaaaa 461161 tggctttctg ccgaagacat acagctcgga gacgaaggaa tacacatatg atagtgaaat 461221 caacctgatt gatcagcttt acgctgcttg gcatttgccg gaaggggatg aaaaagcatc 461281 tgttttagcg gactggatca agcaggaatt tcagaaaaac ggaaagctgt acgggcggta 461341 ttcggcatat acgaaggagc ctgccgtcca atatgagtct ccatccgtat atgccttagc 461401 cgtattgttt ttgacaaaac agcatgaaaa cagttctgtc atcaaagcca tatatgatag 461461 aatgaatgac tttgaaattc atgatccggt gaaatcgtat tatggaggct atatgagcgg 461521 cactcagacg cattcatttg acaatctgct gccgctgtta gccgaaagga agctttttaa 461581 tgaaaatatc attcagtgaa tcacaaaaat tatttgctta tttttcaggg ctcatcgcgg 461641 ccctgtcttt gtttatttat tatgtgtcag cccagcaatc agaaggtgct ctgatccttt 461701 gcatcacatt tggcgtcatc gccgcaggca tctggttcgg cccgatttac gcgctggcag 461761 tgaccttaat cgtactcttt gttctcggca ccttaatgat gtttttccag actggacaga 461821 catcgctctt tccggctgag gaagggctgc gaatgcttgt cgtgtgggga atcgcgcttt 461881 tgctgttttc ttttatttct ggaagaatcc acgatattac agcagagctt cggcgctcaa 461941 tgacacggct tcaatccgaa attaaaagct atgttgctgt tgacagagtg actggttttg 462001 ataacaagca aaggatgaag ctggaacttt cagaagaaat caagcgggcg gagcgctacg 462061 gcaattcttt tgtgtttttg ctgctccata tgcattattt caaagagttt aagtctttgt 462121 acggtgaaaa agaaacggac cgcctcttcc aatatgtcgg tcagcaaatc aggacaagcg 462181 ttcgggaaac ggataagaaa ttccgtccct ctgacgagcg tatcgggatc gtgctgacgc 462241 acacgcctgc tgaacatatg ccggccgttc tgactaagct gaagaaacaa ttggatacat 462301 atcagctgga aaatggaaag tatgtgtcgc ttacgttcca cgtttgctat ttgccctacc 462361 gcaacgatat ccaaacagct gatcaatttt tagaagaact ggaaaacgag atgatgatga 462421 atgaactata aaggaatcac attgctatgc gtcatgatgc ttctattttc agctattgcg 462481 tcttttcccg tttctgcgca agcgaaagat caggatgccg gcattctcat catctactca 462541 accttggacg gcaaagagtc gtcacaagtc aaaatgctcg atttgcttgc gggccacttt 462601 acatcccatg tgacagtcaa aaaagattca gacgttgaag cgtcggattt caaagggaaa 462661 gaccatgtga tttattacgg ccaaacgaaa agaaagctca gccaaaaatt gctgtctctt 462721 atcagcggcg tgaaaaaacc ggttgtcgcc attggctata acgcaggcca aatcagccaa 462781 ttttctgggc tttcattagc ccgcaaagaa aatgtgtttc aggttcacag caggtcagaa 462841 aaggccgatg tgtctctgga aagcgggctt aacgtgctga gtgtatcagg cctgaaagga 462901 acggcgcttt acaccttcaa agcggatgaa ggcacaacgc attcttttat atggaaaaca 462961 aaaaaaggga atgtgtacat tggattaaca aatttgttaa atgacaattt gatcgtggcg 463021 aaacagctca gagaagcttt cggagagaag gcggggacga cgttattgta tttgcgtctc 463081 gaggatatca gcccgatgtc tgatgaaaaa ctgctgcttc aagccggtac atacctgcat 463141 aagcggcata ttccttttat cctggcggtc attccggttt acttgaatcc ggaaacaggc 463201 gacaaagtgt atttgtctaa tcaaccgaag atggtcaagg tgctgaagaa gctgcaaagc 463261 atgggcggca gtatcatagt tcacggctat actcacgctt atcgctacag tgaaacagga 463321 gagggatttg aattttggga tgcaaaggcg gatcagccga ttacatccgg aaatgccgaa 463381 gaccccccgt ccattttgga gaaagaacag gacttcccga acgaacaagc ctatcacagc 463441 tatcttgaac catttcggga aaaggaagaa acgtatacaa aacaaaaact gacgcgtgcc 463501 attgaggatt tgacatcatc gggtctttac ccgctggcgt ttgaagcgcc gcattacacg 463561 atgtccgaat atggctatca aatcgcctcg cagtatttta caagcatttt cggccaggtc 463621 cagctcagca gcacaacatg gaaaacatcc ggtgcacctc cgtttgtgac tgctccttcg 463681 atgctgcacg gaatgacgct ttatccggaa acgatcggct ttgtcgacac atcgaagcaa 463741 aacccgctcg gtgagatgga ggagcatatc tcccagatga ttgattttga aggcggagta 463801 gccggaggat tttatcaccc gtaccttggg atgaaatatc tgcctgagct ggttgatcag 463861 atggaacgca ttccagacag tgaatggctt gatttaaaga aaacgaaaca aaccgtcaaa 463921 acagacaaag tggaaattca tacaagcggt gacggaacga ttcaggtgaa aaacggcgta 463981 agccccattt acgagttttt cgatcatcac cggcaaaccc ctctggaaaa ggcgttatgg 464041 attctctccg ctgttgtgct cttatttgtc atcatgtttg tcagttatac gttttacttg 464101 agagccacat tgaaaaaacg aatttttaag gagagaagaa gccttgggta atacgctgtt 464161 ctttatctcg ctaagtttaa tatgggttat gcttctctac cacatgttcc tcatgcaggg 464221 cgggtttcgc cactatatga ccttcgaacg gaatatcccg aagtggagag aaaatatgaa 464281 ggaactgccg aaggtcagcg tcctcatccc ggcgcataac gaagaggttg tgattcggca 464341 gacgctgaag gccatggtca acctttatta tccgaaggac cggctggaga ttatcgtcgt 464401 taatgataat tcatcagacc ggacgggtga tatcgtcaat gaattttccg agaaatacga 464461 tttcatcaaa atggtgatta cgaagccgcc aaatgcagga aaaggaaaat cctctgcact 464521 taactcgggt tttgccgaat cgaacggcga tgtgatctgt gtgtatgacg ccgacaacac 464581 gcctgagaaa atggccgtgt attacctcgt gctcggcctg atgaatgacg aaaaggcagg 464641 cgccgtggta gggaaattcc gcgtcatcaa tgcggcaaag acgctgctga cgaggtttat 464701 taatatcgaa acgatctgtt ttcagtggat ggcccaggga ggcagatgga agtggttcaa 464761 aatcgccacg atcccaggca ccaacttcgc gatccgcaga agcattatcg aaaagctcgg 464821 aggctgggat gacaaagcgc tcgctgagga tactgagctg accatccggg tatataatct 464881 cggctatcac atccgctttt tccctgccgc catcacgtgg gagcaggaac cggaaacatg 464941 gaaggtatgg tggcgccagc gcacccgatg ggcgcgcggc aatcaatatg tcgtgctcaa 465001 atttttggcg cagtttttta agctgaaacg aaaacggatt atctttgatt tgttttattt 465061 tttctttacg tacttcctgt ttttctttgg cgtgatcatg tcaaatgcga tttttgtagt 465121 gaatttgttt tatgatttgc atttgtctgt tggatttttg gcaatgattc tctggatttt 465181 ggcgtttttc ttatttatga cagaggtcat gattacgttg agcattgaaa aaacagaaat 465241 gaacaagcaa aactttttta tcgtatttct catgtacttc acatactcgc aggcatggat 465301 tgtgcttgtt atctactctt tattcgtaga aatcaagcac cgtttattca agcaagaggt 465361 caaatggtac aagacagaac gatacaatca acataaaagc gggtgacctt tttgaaacaa 465421 ataatgattt ttctcacaag cttcatgctg ctggcgatga ctggacaaac ggctcttgcc 465481 aaagacgtac aggtcagcgg ttcgctcctt gggaaaagca gccaagaaca agccaaacag 465541 caggtgctga caagcgagct gattacactg tatggatcaa aagacagcgc agagctgacg 465601 tatcagatcc cggcaggcgc ctcttcgggc aatcagcaat tggtaatcga atacgaggca 465661 tcaaatcttt taatttctcc atcatcgtta acggttgtca ttgatgatga accggtcaag 465721 acgttaaagc ttgatggtga ttccaaacgg aaaacagtga agctgaatct gaataaaagc 465781 cagtctgcgc aaggctatca caacgtatcg ctgaaattct acggcgtaat gaaagagggc 465841 gtgtgcgtca gacaggatac atcaggcaac tggatcaaaa tttatccgga cagccggctg 465901 acacttgctg acagcagtga agcgaaggga acgtcgctgg accattatcc gtatcctttc 465961 gcccaatctg gaaatacagc ggaagaaaca gctatcgtca ttccggataa cccaagttca 466021 gcagaaatag aagctgctgt taaaacagaa ggctatttga aaacggtgga cagcagtgtc 466081 agtattgcgt atgtcacgga atctgaactg aaaaaaatcg ataagccgac gattgttatc 466141 ggcgtggaca agcattggaa cggcaaagtg aaaaaactgt tgaaacaagc cgggctacag 466201 gcaaaaggag aaaaccttct gcttgcggag cgggtgctga aagcagaggg caaacagcag 466261 ccggttctgt ttgcgcaagc ggcgtccgag gacgcgctca caaaaaaaat cagcgtgatg 466321 acagatcaga catatacagg ccagctcagc ggcgatacac tttcaatcag caagcttcag 466381 cagactgaaa aaaaagaaag cgataagctg acccttgaga attttggagc gggtgatatc 466441 acaattggag ccgacaaaac atcttcagca cattattttt atccggcttc ggctgtttta 466501 gatgaaaacc aatcggcgaa gctgtcgctt aaactgaaaa agtctgaaac gattcaagcc 466561 tcaacggctg aaaacgagtc agcctctcag gctgcagaac tgaaagtgat gatcaacggc 466621 cagccgcact cggtccggct tgatgaatta ggaaaagaag ataaaaacgg attctatcat 466681 gtcacagtga aagtggaccc taagctgctg caaaaaaacc gctacattga tattcagttc 466741 gtcacgaccg gtttaaagga aaacaaccct tgtaacacca ctgatgaaga aaagtgggtt 466801 tttatcgata aaaacagtac attatcatac gccatcaaag gcatgtcccc gtcagcggat 466861 tttcaagagt ggccgctgcc ttacgccgga aaccaggatc aaacaacgtt aatcgtgctt 466921 cctgacaccg taagccaatc gaagctagag gagctttctc tcgtaacaga atcctttggc 466981 aacgaagcac agcattcata tacggtaaag aaatcatctg acgttacagc aaatgatgcg 467041 aaaggacgaa acctcatttt cataggaggg atcaatcaat tttctcttct gaaggagaaa 467101 tcatcagatc tgcttgtgcc gcaggaaaag aacggctcgt ttgatgtatc tagtttcgag 467161 atgctgaatg agacgacaaa acaagtggta tttacccaag catcggtttg ggattcacgc 467221 tatacaatgg ctgtctttgc accgtcaaaa ggagatggca cggctgtcac aaaagagatc 467281 atcagttatc tgaacagcaa cgatgagtcg gcaaccgtcc ttaatgaaac aaacagccag 467341 caggtgttta caaaccacca gcagctcaaa tcggaaacaa acagttccga tgcagaacaa 467401 ccaacacagg atcatagcca gaaatggatg tatattggtg tgctggcact cattatggtg 467461 gttgcggcag tgttcatttg gattgccgta agacgcaaaa aaagaaagac agatacagaa 467521 taaaacagag gcgattttag cctctgtttt tttatttttg gtaagtaaat tccatttgtg 467581 gaacctgtca ttttattttt ttctctcagc caataagcct ctttacaacg tgcgggaacg 467641 ggagtatgat ctcttttaga aaacaaatcg cttaatctga aatcagagcg ggggacccaa 467701 tagaacggct ttttgccgtt ggggtgaatc ctttttaggt agggctaact ctcatatgcc 467761 cgaatccgtc agctaacctc gtaagcgttc gtgagaggag atgaatgaaa cctgtgttcg 467821 atgttatggc acaggggcat ccgtttgcct ctgtgttttt tgttgttcat ttttgaatgc 467881 aaatcgcata cagagacatc atagcagaaa ggactatcat caacatgtga gagcaagaca 467941 ctgatggatg ttttattgtt ttaattgaaa aatgagaaat taaaagggga agacatcgat 468001 gtatcattca atcaaacgtt ttttgattgg gaaaccacta aaatcccaag cagctggaga 468061 gcaaaaactg acgaaattaa aagccttggc tatgctttcc tcagatgcgc tgtcatctgt 468121 cgcatatggg acagaacaaa ttctaatcat tttggcaaca atcagtgcag ccgcattttg 468181 gtactccatt ccgattgcgg ttggcgttct catcttgctg ctcgcactga ttctttcata 468241 caggcaaatt atttacgctt atccgcaggg cggcggggcg tatatcgttt ctaaagaaaa 468301 tctcggtgaa aaaccgggat tgattgcggg cggttcattg cttgttgatt atattttaac 468361 agtagcggta agtatttccg caggcacgga tgccatcacg tcagcctttc ctgcattgca 468421 tgattatcat gtgccgatcg ctatttttct cgtgttagtg attatgattt tgaacctgcg 468481 cgggctttcg gaatcagcat ccatacttgc ctacccggtt tatctgtttg tggtggcgct 468541 tttggttctc attgcagtcg ggttgtttaa acttatgaca ggacaaatag accagccagc 468601 ccatcataca tcgctcggca cacctgtagc cggcattacg ctatttttgc tgcttaaggc 468661 tttttcctcc ggatgctcag cgttgaccgg ggttgaggcc atttctaatg cgattcctgc 468721 attcaaaaac ccgcctgcgc gaaacgcggc aagaacgctt gcgatgatgg ggattttgct 468781 ggcgattctg ttttccggca tcacggttct cgcgtacggg tatggtacgg cgccgaaacc 468841 tgatgaaaca gtggtttcac aaattgcgtc cgaaaccttt gggcggaatg tgttctacta 468901 tgtcatccaa ggtgtcacat cgcttatttt ggttcttgcg gcaaatacgg gattctcagc 468961 cttcccgcag cttgccttca acctggcgag agaccagtat atgccgcgaa tgtttacagt 469021 caggggcgac cgcttaggct tctcaaatgg gattatcttt ttaggctttg cctccattgt 469081 tctcattatc ttattcgggg gacagacgga gcacttaatc ccgttatatg ctgtgggcgt 469141 atttattcca tttacgcttt cacaaaccgg catgtgcatg aaatggatca agcaaaaacc 469201 aaaaggctgg atcggaaaaa tgctgatcaa ctcctgcggc gctctgatat catttatggt 469261 tctatccatt ctgtttgtga cgaagtttaa tgtcgtatgg cctgtgttaa tctttatgcc 469321 tatcgtcgtt ttgctgtttt ttgcgattaa aaatcactat actgcggttg gtgaacagct 469381 tcgcatcgta gacaaagagc cggaagaaat caaaggcacc gttgtgattg tgcctgtggc 469441 cggtgtcacc accgtcgtgc aaaaatcgat tcactatgcg aaatcactgt ccgatcaggt 469501 gatcgccgtt cacgtgtcat ttgacagaga acaggaaaag aaattcgaaa aacgttggga 469561 agagcttaat aacggagtgc gtctcgtgac gcttcactcc tcttacagaa gccttgtcca 469621 tccgtttgat aagtttttgg aaacagttga ggcaaaagcg aagaaggagc agttttccgt 469681 tatggtgctg tttccgcaat ttataacgaa aaaacgctgg cacaccatcc ttcacaacca 469741 atcggccttc ctcctcagag tccggctgtt ctggaaaaag gacataatgg ttgccacact 469801 gccgtatcat tttaaaaagt aaagctctag gaccaaggga atcaccttgg tcctttttag 469861 cgggaaaagg aggtatgggg gtgtatacac aaggtgcttt tgtgatcgta ttgaacgaaa 469921 gtcagcaaat tctgctggtg aaacgaaaag atgtccctct atgggatttg ccgggcggca 469981 gggttgatcc cggggaatcg gctgaggaag cggcagtgcg ggagatattg gaagaaacgg 470041 gatacaatgc agcgctttct gcgaaaatag gtgtttacca aaggccaaag tttcaagatg 470101 aacagcatct gtttttcgga agcattacag gcggacaagc aatggctgac ggcacagaga 470161 cagcgggatt aaagtgggtt tccccggggc gtttgccgct ttttatggtg ccgaatcgaa 470221 aaaggcagat caatgatttc aagaacggcg ctcaagatgt aaatgtcacc gtcaaggata 470281 gcgggttgct cgcggcgatc gacctgttga aaagaagact gggcaagtga ttcaggtctc 470341 cgggttttaa agcctttctc ctgtggtatt gaaaaaagga aaaaggagga tacgttatgg 470401 cacacaaaac tgcaggacaa gcaatgacag agctgcttga gcaatgggga gttgatcatg 470461 tatacggcat ccccggagac agtataaatg agtttatcga agaattaaga cacgaaagaa 470521 atcaactgaa gttcattcaa acccgccacg aagaggtagc ggcactggca gccgcggctg 470581 aagcaaaact caccggcaag atcggagtct gtctgtcaat cgcagggccg ggagcggtgc 470641 acttattaaa tggtttatat gatgctaaag ccgacggcgc ccctgtgctg gcgattgcag 470701 gacaggtttc ttctggcgaa gtcggacggg actatttcca ggagattaag ctggagcaaa 470761 tgtttgagga cgtggccgtg ttcaacagag aggtacatag cgcggaatca cttccggatc 470821 tcttaaatca ggcgatcagg accgcctaca gcaaaaaagg cgttgcggta ttgagcgtgt 470881 cagatgattt gtttgcggag aaaatcaaac gggagcccgt gtatacttca ccggtgtata 470941 ttgaagggaa cctagaaccg aaaaaagaac agctcgtcac ctgcgcccaa tatattaata 471001 acgctaagaa accgattatc ctggcagggc agggaatgaa aaaggcgaaa cgggagctct 471061 tagaatttgc ggacaaagcc gccgctccga tcgttgttac actcccggca aagggtgttg 471121 ttcccgataa gcacccacat tttctcggca acctcggtca gatcggaaca aagccggctt 471181 acgaggcaat ggaggaatgt gatttattaa tcatgctcgg aacgtcattc ccgtaccgtg 471241 attatttgcc tgatgacacg ccggcgatac agctcgattc agacccggca aaaatcggaa 471301 aacggtatcc ggtgacagcg ggccttgtct gtgattcggc tctcggtttg cgcgaattga 471361 cagagtatat tgaacgcaag gaagacagaa gattcctgaa tgcctgcaca gaacatatgc 471421 agcattggtg gaacgaaatt gaaaaagatg agacagaggc aacaacaccg cttaaacctc 471481 agcaggtcgt ggcccgtctt caggaagcgg cagccgatga tgcggtgctc tctgtagatg 471541 tcggcactgt gacagtctgg atggcgcgtc atttcaaaat gaacgcgaat caggatttca 471601 tcgtttccag ctggcttgcg acaatgggct gcggcctgcc gggagcgatt gcagcgagct 471661 tgtccgaacc ggaacgccag gcgatcgccg tctgcggtga cgggggattt tccatggtca 471721 tgcaggacct tccgaccgcc gttaaatata agctcccgat cacagtcgtt attttaaaca 471781 acgaaaatct cggcatgatt gagtacgagc agcaggtcaa aggcaatatc gactatgtca 471841 caaaacttca aaatgtcgac tatgccgcat ttgcagaaag ctgcggagca aagggcatca 471901 aagtgaccaa agcggaagag cttgcgccgg cttttcatga ggcgctgcac tctgaccaac 471961 cggtcgtagt ggatgtcatg attggaaacg aaccgccgct tcctggcaaa atcacctacg 472021 ggcaggcgaa aggctttagc aagtacatgc tgaaaaactt cttcgaaaac caaaaatttg 472081 aaatgccgtc actgaagaaa agtttgaaac ggttatttta aaaaaacagg ggccctaaga 472141 gcccttgttt tttttttttt ttttggaaac aaatgtattt tcagcatgtt tgaattcata 472201 aaatgatcgg tatatgtatt aggaactgat ttcgccatac tcgaaacaga caaaaggaca 472261 aatgcatctt gtttcaaagg aagatgcatt tgtccttgca tgcttattct tatcaaatct 472321 tacagaactc ttctcataat aggttatttt tcttttttct tcagcccgaa gaagaaagga 472381 aaagcagaac cgaccaagaa ggtgccgaat aaaaacatgc cgccgataaa cacgtggaaa 472441 tttgtgtgtc cggccgtaaa cgccgtgatt agggaaatga tactgagcac gatcatggca 472501 atgccgggcg cgactctcat ttttcccttg gatttatggg cagcaacaga acataaaatg 472561 ccgataacaa taggaacaat ccacaaataa aacagaataa atactgacat catcaaaact 472621 ccgatttttc ttctatcata acaaatttct gtcaaaaagg gtatcaatga gcttttgcgg 472681 aaaaataaaa accggcttta gaagccggtt tttttatcga aacgtatcta caattaaaaa 472741 cacattcaaa gcaacgatca atacagcaat cagccaagac accactgtga tccatttggc 472801 gttgatcaga gatcccatga tccgtttatt gcttgtaaac ataataagcg gaatgagggc 472861 aaaggcgatc ccgaaggaca gcacgacctg gctcagtacg agagcggtcg tcggattaac 472921 acctgacgcg atgatcaaga tcggcggaat gatcgtgata aaacgccgta catacagcgg 472981 aatgcggtag ttgataaatc cttgcataat cacgtcgcct gaaagtgtgc cgacagacga 473041 actggataga ccggcaacga gcagcccgat cccgaacaaa gccgcagaca tagggctgac 473101 aagatgtccg aattgctgaa atgcgacgtc gagatcctca acaaacaggc cgtttttgaa 473161 gaataatgcg gcagccacaa tcagcatact tgcattaata gcccctgcaa tcagcatcgc 473221 tattaaaata tcaataaatt caaacctaaa gatttttttc cgttctgcat cagttttgcc 473281 aaccacccgc cgctgtgtaa gggcagagtg taaataaatg gcgtgcggca taacagttgc 473341 gccaagaata cccgctgcaa gaagcacact gtcggtgcca tgaaacgccg ggacaaaaag 473401 gcccttcatc actgacacgg catcaggctt tgcgaaaaag gtctgcaacg caaaggcgat 473461 cacgaccaca aacagcatac cggcaatacc tgcttcaagt gagcgataac cacggcgctg 473521 aagctccaat atcgcgaaag aaccgatcgc cgcaataata gacgcttcaa gcatcggaat 473581 gccgaacagc aaatacagtc ccagagccgc tccgataaat tccgccagat cagttgcgat 473641 aatgaccaac tcgccctgaa tccataatcc gatcgagaca ggcttcggga attcttcacg 473701 ggcaacctca ggcagatttt tgcctgtcgc aataccgagt ttggcggata gggattgaat 473761 taaaagcgcc atgatattgg aaaataagat cacccataag agcatatatc cgtatttaga 473821 acccgccgaa atattcgttg cgaagttgcc gggatcaata taggcaatgg ctgctataaa 473881 tgcagggccg agaaaaggga gcagccctct gaatcctctg attttcccgt caagcgcatc 473941 ttggacggct ttggaacggg gagattgtgc tgtgatgtcc ttgttcatca tgtctcacct 474001 gaattctgtt tgtttttgcc gtacaacaaa gagtttcctt aaggcaaatt attttatcta 474061 catcatatga ccatcccggt ttcttgtcaa ccgaaaatgt tcaaaataca cttctgaatt 474121 tttccctgtt atgtaacatg atatgtaggg attcgtgata aggtcccata taaaaagaca 474181 tcgtttcatt tcgaaacgat gcctcctgta tctaatgagt ctaggcttcc ttccgcagcc 474241 cgcggaatat aaggcccagc aagaacacga agatggctgc cccgatgatg gccgggaaaa 474301 tagcaaagcc ggcgaggctc ggtccccatg tgccaagaag tccgtgccca atccaagcgc 474361 cgatcagccc ggcaatcata gagccgaaaa ttcctcccgg cagccggttt cctacaatgg 474421 cgctcccaat taatccgata acaattgcaa caactaatga aaccaaaaag ctaagcatca 474481 tgatcacctc tcataaatga tttaccaatc aataaccgct cctgatcatt tcgaaacact 474541 tgaaagcata ttcctttatg atcctgtttt aatctttctc tgcacactgc cgtcagctaa 474601 atgaacaatg acctcagtgc ctttatgcgc cgcgatttcc tttgcccgtt caatcgcttc 474661 tttctttgta tccttgattt cagacacacg tttggcgccc tcggctttga ctgcccagcc 474721 ttttttatgc ttaataacat gctctgcttt attcatgagc tcggggccgc tgccgctgct 474781 tggatcagca tcgcgttctg tctcatcatc atgcgtcagg aaatcatcaa tttcatctgt 474841 agaggcgttt tccgcccatt ccttcgcttt gcttgtcgca attggaatcg cgcgcccttc 474901 ctcatagcct tcatcaatca tcgcattcgc aatgtctatc gccttttttc tcaccggctt 474961 ctcaagattt tttaatgaag caggataatc cttcatcgac caaggcatgt ctatcactcc 475021 ttttcctttt ataaaaatgg tacccgcagg tgaaaaataa aaacgcatcc gaaaaaatga 475081 aggtatacta tatagtagaa aaaacggaag ggaagtgcgg gttgggtgcc aacagaacga 475141 aaagaagact tacatcagca attaaaagag atagagaaat gggaaaaaga tcagcaaaaa 475201 gtctggtttt gggaaaagct cagccgtctc ccgtttcaac tcctggacaa gctgacacca 475261 gaattcatcc agaaaaagat cggcaagctc ttggatgagg tcggcagctt tgttcaaaca 475321 ggcggacagt acctgacatc tgaaaaacag attatcagga tgtttcaaaa gaaactgccg 475381 gaggagatct ttgaatcgct ggaggacatc cggaaagcgc ctcttcctgt catggatgaa 475441 attgcggaag gaatgggcaa aaacagaacc aacgcagcaa ccgttcaagg cgcgacaacc 475501 ggtgtgggcg gcgtgtttac gctggcggca gacattccgg cagtgcttgg cttatcacta 475561 aaaacattac aggatatcgc agtcgcatac ggctatgacc caaaggagaa aaaagaacga 475621 gtcttcattg tgaaatgcct gcagcttacg tcggctgatg ttgtcggcaa aagatcgatt 475681 ttgcaggaat taaaacacta cgatcaagac cgtacatata agaatgtcgc ttctcaaatc 475741 caaggctggc gagaagtcgt tttgggctat cgagacacgt ttggctggaa aaaacttttc 475801 cagatagtgc cggttgccgg aatggttttt ggcgccgctg ccaatcgctc aacattaaac 475861 gacattaccg agacaggcat gatgctgtac aaaaagaggc gcattcttga acgactgaaa 475921 gaaacagaac gagagatgga atagcagaaa gcagacggac accgcgatcc gcctgctttt 475981 tttagtggaa acatacccaa tgtgttttgt ttgtttaaaa gaattgtgag cgggaataca 476041 acaaccaaca ccaattaaag gaggaattca aaatggcaga caataacaaa atgagcagag 476101 aagaagcagg tagaaaaggc ggagaaacaa caagcaagaa ccatgacaaa gaattctatc 476161 aagagattgg tcaaaaaggc ggagaagcca ctagcaaaaa ccatgacaaa gaattctatc 476221 aggaaatcgg cgaaaaaggc ggagaagcca ctagcaagaa ccatgacaaa gagttctatc 476281 aagaaatcgg tgaaaaaggc ggagaagcca ctagcgaaaa tcatgacaaa gaattctatc 476341 aagaaatcgg ccgaaaaggc ggagaggcaa caagcaaaaa tcatgataaa gaattctacc 476401 aagaaattgg ctcaaaaggc ggaaacgccc gcaacaacga ctaatcaaaa gcataaaggc 476461 agacaacctg taaataaaaa agcgatccgg cacatcagct ggatcgcttt tttttggaat 476521 cttctcaatt tatgccgcta ttgagataca ataagtgaaa aaggggtttt cgctaatgtc 476581 caagatgcaa aacttgctcg ccatcgcaaa tgaagtcaaa gaaaagcacg ccaatttttc 476641 aatctcagag gtcaacgacc actgcgtgcg ccttgcggtg tttacgggag aatatgactg 476701 gcaccatcac cctgactcag acgaattgtt tattgttctt gaaggggagc tgctgatcga 476761 ttttaaggac aaagaaaccg cggtgctcaa agcaaatgac agcctgctga tccctaaagg 476821 cacggttcac cgcacacgct cttacgtcag aacggtaaat ctctgtgtgg agcataaaca 476881 agccgaaacc gtcatcatag aggagcagcc atgctaatca aaaagatgat atgtgaagta 476941 gatgctgcaa acgctgaagc atttgcaaaa gcgcagtcac agtgggaagc gttatcgcat 477001 ataagcggct ttatcaaaca ggccggcggc tggcgaaaaa cgatagacga gccgctcacc 477061 gcagaaatca tcagtgtatg ggaaaacaga gaagcctatg atcattttat ggagaacgaa 477121 catgacagca tatacgagga aaacgatcag aaggctgtaa ttctttcgat agaggtgacg 477181 gtgtacgaag aggataaacc gttcgttcac gatctgttac ataaccccga tatccggtac 477241 gaaccaaact ggacggttct gaaggcataa tcaaagccca aaacatcatg ttttgggctt 477301 gtctctttac tcgcgtcccg gaagtgtatt atgaacaaaa ggcggtgctg gttttaactc 477361 cggtttttct ccaaacgttt ttgcttcttt cacatattca aaggcttctc cgtccggcgc 477421 tttttcattc agccagtttt gctcggcgct tacttcgcct tcagagaaat tgataagctg 477481 atgtgagaac tcttgttttt cgagcgcttt cgggaatgta cccggcacaa ccggaccttc 477541 ctgtgcttct aattctttaa tggcggcgag ccattggttc tggtgcatcg tgtcacgcgc 477601 cagcaggaag ctgagcatat ctttgacgcc tttgtcatcc gtcatttcaa acaggcgtgc 477661 gacctgcaga cggccctgag attccgcatt caggttggcg cggaagtctg ccagcaggtt 477721 tccgcttgct acgatataac cgccgctcca aggtacgcct gtactgcttt ccggcatggc 477781 gccaagtcct gatacaatcg catggtgagg gttcatgccg cctaggatgg agccgatgac 477841 cggatcttca gcagcttttt cctgctgatc aagaggggca tcctcaagaa gtctggcaat 477901 catcgttgcg atcatttcaa catgcccgag ctcctcagtt gccgtatcca tcagcaagtc 477961 cttgtatttt tcatttcctc ttgtgttcca gccttgaaat aagtactgca tggcaactga 478021 aatttctccg aattgcccgc ctaaaatttc ttgcattttt ttagcgaata atggatctgg 478081 acgatctggt ttagcaggat gctgcagcat ttttgtgtgc ttaaacatgt acccatctcc 478141 tttttcgttt atctcttttt atatttccga tcgatagaaa gataaacgaa aaacagcgta 478201 tcgagatggg aactatgaat cttttcgcag ctccaacagt tcccggatca gctcccggcc 478261 aaagatgggc tcatactgcc ggtaaacagg gtcaagacgc ttcatccatt cttgtttctc 478321 tttatctgac agctcataaa tatgtatagc agaattcttt ttgatttctt ccagctgctc 478381 cttgttcatt tgttcggcat acgtttcatt ccactccgtt gtctccttca tcgcttcagt 478441 caaaatgcgt cttgtttctg gtgtttgcgc cttccagaag tgttcatcag tcatgacagc 478501 gtagccgaga taaccgtggc tgcttattgt caaatagtcc tgaacattat aaaatttttt 478561 agaatagatg tttgaaattg tattttcttc gccatcgact acattgtttt ctaacagctg 478621 aaaggtagaa ttgaaggatt cctgatgagg tgttgcgcca agcagcttga actgatcctc 478681 aatcacatcg ctttgcataa tgcgcagatc ctgccctttt aagtcatccg gtgttttgac 478741 cggcccttga tttgttgtga tttgcttaaa gccgttcgtc caataggcca atcctttcaa 478801 ttggtttttc tttagagaat caaacagctg tgtgccgatg cttccgttca gccctttttt 478861 gacggcgttg taatctgtaa atgcatacgg cagatccagc actccccatt caggcgagag 478921 catgccgagc ttcgatgtgg agggggcgat aaattgaaca tcgccgtttt gcaatgcttc 478981 aatttcttca atgtccgagt acaggcttcc attcggaaat acttctattt ttatttttcc 479041 gcctgatttt tcgttcacca gatcagcgaa tttattggcg gccagccctt ttggcgtatt 479101 ttcagcaacc acgtggctga atttaaacac gatttgatcc tgcaggcctt cctggtcgtc 479161 atcataaaca atctttttat tgccggtatg atcatggaat ccgataaata aagcggttgc 479221 aattccagcg atcatcagtg cgagacatgc aagcaaactc ttcatgaaaa gccctcccct 479281 atgttaagga taatgggggc tatgacattc gtaaagacct gaaaggagaa gctgatgaac 479341 aaaaagaagc tctcaatccg ttggaaaatc acgatcttat cctatatact cgtcattttc 479401 tcctttttga tcggcggcat tgtgctcatc ggcaacattc agcatacaga ggagcgggag 479461 ctgaaaaagc ggctgatgaa tacggcccgg acggtgtcag agatgacaga agtgaaagaa 479521 gccttggcgc gaaaaaaaca aacagaagcg gttcgccatg cggttgaaga aatcaggatg 479581 attaatgaag cagactatat tgtcgtcatg gatatgaatc acatccgata tacgcatcct 479641 gtcagcacaa gcattggcaa gaaatcagaa ggtgcagacg aggaggcagc ttttgcggag 479701 cacatttatt tctctgaagc aaagggcgag atcggcacgg cggttcgcgc tttttatccg 479761 gtaaaggatc aagacctgaa ccaaataggc gtggtgcttg tcggaaaaac gctgccgggg 479821 atcgctgaca tcctgcttca tttaaagcgt gatatcgcct tcatcgttgt gctgacactc 479881 ggctttggcc ttgctggttc ctttttgctg gcccgccata tcaaaaaaca aatgtttcag 479941 cttgaacccc atgagattgt ccgaatgtat gaagaacgga cagcgacgtt tcactcgatg 480001 aatgaagggg tgatcgctat tgacaatcgt ctcgtcatta cgatcttcaa tgaaaaagcg 480061 aaacagatct ttgaagtgca gggggatcta atcggcaagg tgatttggga ggttctcaag 480121 gattcgcgcc tgcccgaaat cgtggagcgg aacaaagcgg tttataatga agaaattcgt 480181 gtcagcggta aggtgatcat gagcagcaga attccgatcg tcatgaagaa aaaagtgatc 480241 ggcgccgttg cgatttttca ggacagaacg gaagcggcca agatggcaga ggaattgact 480301 ggtgtcagaa actttgtgga ggcgctccgt gtccaaaacc atgagcatat gaataagctg 480361 cacacgatcg ccggtctcat ccagctgggg aaatctgaaa aagccttgca gcttgcattc 480421 caggcgtcaa ctgagcagga aaatgtgact gaatttctgc accgctcgat tcaaaatgac 480481 gctgcggcag gccttctatt aagtaaaatc agaaggggaa gagagctcgg cattgctgtt 480541 catatagatg aaaacagcag tcttcagcaa tttcccgagc atgttgatca gcatgatatt 480601 gtcgtgcttt tggggaatct gattgaaaat gccttcggct catttgaaac cgttcaatct 480661 gaagacaaac gaattgacat tagtatcgaa caaacagatg atatccttgc tattttaata 480721 gaagataacg gctgcggaat tgaaccgaca catatgcctc gcctttatga caaaggtttt 480781 acggtcaata aaactggcgg cacaggctat ggcctgtatc tagtgaaaca aatcatagac 480841 aaaggatcgg gcacgataga agttgattca catgcggggc aggggacatc tttttctatc 480901 gtttttccaa tgaaggggga ggaagcacag catggctcgt aaagaatgga aggttctgct 480961 cattgaagac gatccgatgg ttcaagaggt caataaggat ttcattacaa ctgttaaagg 481021 cgttactgtc tgtgcaacgg caggaaacgg agaggaaggc atgaagctga ttaaagaaga 481081 acagccagat ctcgtcattc tcgatgtgta catgccgaaa aaagacggca tcaagacctt 481141 gcaggagatc agaaagcaaa agcttgaagt ggatgtcatt gtcgtctccg ctgcaaaaga 481201 caaggaaacg atctcactca tgctgcaaaa cggggcggtt gactatatct taaagccgtt 481261 taagcttgag cgaatgagac aggcactcga aaagtacaag caatataaac aaaaaatcga 481321 agcgaatgat acgctgtccc aggaacagct cgatgcgatc ctgaatattc cgcagcaggc 481381 cgtacaggat ctgccgaaag ggttgaatca cttcacgatg aatgaagtca ctgctttttt 481441 gaaacagcaa accgcatccc tttctgctga agaggttgcc aaggcgctcg gcatcgccag 481501 agtgacagcc agacgatatc ttgattactt agaaaaaacc gggatcatca aattggacgt 481561 tcaatacggc ggagtcggcc ggccggtcaa ccgctacgtg ttaaaaggat aaacctgaga 481621 ccaaaaagac caaaatgtcc gttatgatca taaacttccc cagactgtat gaaaacgcta 481681 tcattctagt aagaaagaca caaaaggcga ataggacagg gggatgaagg atatgaaact 481741 gtttaaaaat ttaacagttc aggtcataac cgcggtcatc atcggggtca ttgtcgggct 481801 ggtctggccg gatgtcggca aagaaatgaa accgcttggt gatacattta tcaacgctgt 481861 taaaatggtg atcgcaccaa tcattttctt cacaatcgtt ctcgggattg caaaaatggg 481921 cgatatgaag aaggttggaa aagtaggggg aaaagcgttt atctatttcg aggttgtcac 481981 caccctcgca ctcattatcg gtttatttgt cgtcaatatt atgaagccgg gtgcgggtct 482041 tgattacagc aagcttgaaa aaggagatgt atcacaatac acgcaaaatg gcggtcaggg 482101 aatcgactgg attgaattta ttacacacat tgttccgtcc aacatggttg atgccttcgc 482161 aaaaggggac attttgcagg tcttattctt ttctattctt ttcggagtgg gtcttgcggc 482221 attaggcgaa aaaggaaaaa gcgtcattga tttcttcgac aaggtttctc acgttttttt 482281 caaaattatc ggctacatta tgcgtgccgc gccaatcggg gcattcgggg cgatggcgta 482341 tacaatcgga cacttcgggc tcgattccat caaaccgctg gcaagcttaa tgatgtctgt 482401 ttatattacg atgttcctgt tcgtatttgt tgctttaaat atcatctgca agctttacgg 482461 attcagcctg tggaattacc ttcgcttcat taaggatgag cttttgatcg tgcttggcac 482521 aagctcttcc gaatcggtgc ttccgcgtat gatggataaa atggagcgct acggctgttc 482581 caaatccgtt gtcgggcttg ttattccgac gggctattcg tttaacctcg acggcacatc 482641 catctattta tcaatggcga ctgtcttttt ggcacaggtg tttggagtag acctcagcat 482701 cggccagcaa attacgatta tcctcgttct gatgctgaca tcgaagggag cggcaggtgt 482761 gacgggaagc ggatttatcg tccttgcctc aacgctgtca gcgctgcagg tcattccgct 482821 ggaggggctt gcactcctgc tcggggtcga ccgtttcatg agtgaaggaa gagccattgt 482881 gaacctgatc ggaaacggaa tcgccacgat cattgttgcc aaaagcgaaa atgaatttga 482941 tgaagcaaaa agcatagagg ctgttgaagg catgaaaaaa atgaaaacag cagtctgaaa 483001 aaagaacggc ccatccatgg gccgtttttt taattgttta agaattatta aggtaaggac 483061 agagacctca gcattttttt gttatataat ttacaaatgg atactatatt gaatgaagga 483121 cgtttgtcct aacaggagtg tataaatggc cgctttagtt aaattttttc agcacccggg 483181 agtaaggcgt ttctccatct ttgtcgtgtt aactggtgtg ttatatctat ttaagagcat 483241 gatcaactta atattgctta ccttcatttt cacatttcta atggatcgtt tggagcttgt 483301 cgtgcggcag tttgtaagcc agttcttccg cgtgagccag cgggttgtca ttacgtttct 483361 ttacatgttg ctggctgtgc tgcttacagt cgggggcttt gtgttttatc cggtcgtcgc 483421 ggcgcagatc cagcagctgg taaagcagat taaacatatt gcgtatcatc ctgacagcat 483481 ccctttcttt gatgagatca ccagtgtctt cggagatatt aacatcagtt catatgtcaa 483541 agagggcttc aatgtagtgt atacgtatct ggccgatatc agcacattcg gcttgcaggt 483601 cgtgatggcg ctcattctta gcatgttttt cttatttgag aaaaaacggc tttctgaatt 483661 catggcgaaa tttaaaacga gcaaacttag ggtcttttat gaggagattg cttttttcgg 483721 aagcaaattt gcaagaacgt tcggcaaggt gctcgaggct caatttatca ttgcgctcgt 483781 caactgtatt ctgacgttta tcgcgctttg gattatgcat tttccgcagc tgtttgggct 483841 ttcgattatg gtgttcttcc ttggattgat ccctgtagca ggcgtcgtca tttccctgat 483901 tccgctcagc attatcgcct acagcactgg cggtggaatg tatgtgctct acattgtcct 483961 tgtcatattc gccattcatg cgatcgaaac ctatttctta aatccgaagc tgatgtcggc 484021 gaaaacagag ctgccaatct ttttcacctt cacagtactc attttctctg aacacttctt 484081 cggcatttgg ggtttaatta tcgggattcc gatctttgtg tttctccttg atattctgga 484141 tgtcaccaac aaggaagata ggtctaaagg accccgagag aatagcgata aaaagtagtt 484201 taaaatcgaa taatgagtgt gcctcgatct gccggcctgc ctgttcaggg catggaatta 484261 agactcggaa tcggagcttg gcattgcctt gcacagtggt gaacacaaca ggtgacaatg 484321 cttgtcatca gtacggaaac tgaaaagaac aaacagtcgg agcaaacgct catcatcggt 484381 ttaaccaaac atttggaagc aacaaatgct ataatacaaa cagtgcctaa tgttgggcac 484441 tgtttatttt ttgtcgaaaa aggaggaagg ctttatggct gagccgattt tacatattga 484501 aggcctcgat aaaaaaattg ggtctaaaca gattttaaaa cagatcagca tggacgtcat 484561 ggagggtgaa atcatcggcc ttctcggtcc gaatggttcc ggaaaaacaa cactcatccg 484621 tatcatcgtc gggctgttga aacaaaacag cggaagcgtg acaatcagcg gattccagca 484681 tgatacagag tttgaaaaag cgatggaagc ggttggagcg attgttgaga accctgagtt 484741 ctatccgtac ctgacaggct gggaaaacct caagcacttt gcgaatatgc acaaaaaaat 484801 agcggatgaa cggcttgatg aagtggtgga acgtgtcggg ctgacgtcag cgattcatga 484861 taaggtgaaa acctattccc ttgggatgcg ccagcgtctg ggaatcgccc aggcaattct 484921 tcaccggccg aagcttctca ttctagatga accgacaaac ggcctcgatc ctgcggggat 484981 gaaggatttt cgggatcata ttaaggaact cgcagaaatg gaaggaacag ctgtcctgtt 485041 cgccactcat ttattgcgcg aggttgaaga cttgtgcgac cgtgtcatca tcattcaaaa 485101 aggtgagatc aaagcggaag tcagcttaca aggaaccgat caaaccacag aaaaagcgat 485161 tatagaagtg cagccgcaag aaaaagcgct caattggctg acaggcaatc aatatcaagc 485221 tgagagccaa gacgggacga ttgtagttga ggtggcaaaa gaaaacatac cggagctgaa 485281 ccgatcactt gtcggacaag atctgaatgt attttccatt acgccttaca cgcagtcact 485341 ggaagacgaa tttataaaag cgacaacagc tcatcaagag gagggagaag agcttgtcta 485401 aattaatttg gaatgaacat atgaaacttt ttaatcggaa ggtcactttg gtttctctta 485461 tcctgatggc tgtctttcaa ttcttcatgg cattgatcat taaacggatt gtcatcagtg 485521 ccggaacaga tgaaaacttc atcggctatt tatcgtatac accgagcctg aacattttgc 485581 tgcaggcttt aacgatcgta attgcagcaa caattgtttc gatggaattt gataaaaaga 485641 cgatcaaatt tttgctcatt cgtccggtta aacgccaaaa ggtcttttgg tcaaaattaa 485701 tcacagtcgt gatggtcagc ttctatttgt atttggcata ctacattctg gcattattat 485761 tcggtctctt gttttttggc acatcggtga ctgcggaatc aaagacattg ctggtcaaca 485821 ccttggcgct gatcgggtca aactggcttg aagctgtaat gatgggatta ttcgggctgc 485881 tttgttcttc gctgttccgc aatagcgcgg tagcagttgt tgtttctttt gtcgttttat 485941 acggagcgag tacacttgtt cagctcatga agttgtttga aaacaagtgg ggcagctttt 486001 tgctttttgc gaacactgac tttacgcaat acagaagcgg agagacagcg ttgttttcag 486061 gcatgacgcc attgttttca attggaattc tcatcataca tgccatattc ttcatcgttg 486121 ttggctggtg gtgcttctgt aaacgggatg ttcgggtcta aaggcaagga atgacatttt 486181 tgtgaaaaag ctcacgtaaa tcaatatcat ttgatatttt ggtttatact aaaggtactg 486241 acggaggtgt ctcgattgag gaactttatt accgctttac cgatcgtatt gctgcttgga 486301 ttctcatttg tgtcattcat gtttcagttt gaacatcttg tttatttcag gctcgcgctt 486361 gggttgtttt ctctcgtggg actgtacatg atatataaaa tgaagacggg catccgctat 486421 tttatcatct atctgtatgc cagctggatt gtgttggccg cagtgaccgc ttttgaagag 486481 ccgattttct caagcttttt ctttggcggc ctggtgatga cgatgggtta cctgacatat 486541 atgctgattt atctcggcat gaaacaagac cgggatgcaa atcctgtgta atcgcgctgt 486601 tcccttgggg aacggcgtgt ttttctatac tgggcaaaag gttaacagtt gcggaaaaat 486661 ggcaggaaat ctataataca tattaaattt atcggaatta aaactggggg gctgccggat 486721 gtcattattt atacaaaacg atcaacagcg gcaatggatg gagaaaatcg gacggattgc 486781 ggatgaattt cagcaaacag ctgctgaaga tgacgaacag ggacgttttc ctgcagagaa 486841 aatacaaaaa ctgcgtgatg ctgggtatac agcattaaca ttgccggcat ctcatggcgg 486901 agggggcatt tctgtttacg atatgctctt gtttcaagaa cggcttgcac ggggagatgc 486961 tccgacggct cttagcatcg gctggcattt gagcgtgatc ggggagcttg gagaaggcaa 487021 cagctgggat gaagacgtat ttgcatttgt tgccaaggaa gtccaaaacg gagccgtcat 487081 taacagggcg gcgactgaag cgaaaaccgg aagcccgaca agaggagggc gtcccggtac 487141 acacgccgtc aaaaaggatg gcaaatgggc agtgaacggg agaaaaacct ttacgacgat 487201 gtcacaagct ctggattatt ttttagtaac cgcatggatt gaggacaaac aaacaacagg 487261 cgtgtttctc attcataaag atgatcccgg cttgtcgatt gaagaaacgt gggatatgat 487321 ggcgatgcgg gcgactggga gccatgacct tgtactgaac gaagtaatgc ttgatgagaa 487381 taagctggtg gaactgcttc aagggcctcg tggagctaag ccgaatggct ggctgcttca 487441 cattcctgcg atttatcttg gtgtggctca agctgctcgt gactatgcag tgcaatttgc 487501 atctgagtat tctccaaaca gcttgaatgg accgatcaag aatgtcccgg ccgtacagca 487561 aagaacaggc gaaatggagc ttgaactgct caatgccaga cactttcttt tccatatcgc 487621 tcaattgtat gacgatccgg tgcggcgtcc acacttgacc agcgagctcg gtgcggcgaa 487681 acatatcgtc acaaacgctg cgctgtctgt tgttgataaa gcgatgagaa ttgtcggggc 487741 caaaagcctg gaacgaacca acccgcttca gcgctattac cgtgatgtgc gcgccggtct 487801 tcacaacccg ccgatggatg acgccgtgat acacaagctg gcagctgaag cgtttgagtc 487861 ataaaaaaaa gagccttacc ggctcttttt atgtattgtt ttgctcttgc agattttttt 487921 gatgcttgcg gtcgatcctg tcataaataa cgttcatcag ctttggattg cccataatcg 487981 cctctttgtt ttcctggatc agctgttggt aagttttcac tttacgcttc ggcatgctcc 488041 ggcgccctcc tgacatgttt gtattcactt tctaactccg tcagcgacaa ttcatacaga 488101 tgacgctttg actttttgta tataccattc tgtattaaca gatgaatgag ctgttttttt 488161 ctgatttctg cagactgagg tgtcattgtg tcaccaacct ccaatcaaac gatattgata 488221 atcattatca attaacttca gtatacaatg tccgcaatag cctgtaaaga tgaaaagagt 488281 cctattcttg gccaatttac aaacattcaa caaatcgaca aaaagtttcc cgggcaataa 488341 tttgctgtcg aaatattccg cttcattgaa cgcaccctgc tatttttcat gttttgaacc 488401 atactatgta atagaatgga ggctggtatt caatggagcg gacagaaaat ctgaaaaagg 488461 gagaaaaagg ggcgctcctc aatatttttg catatgtcat ccttgctgtt gtaaagctag 488521 ttatcgggat tctatatcat tctgaagcgc tgagagcaga cgggttaaat aatggaacag 488581 atattgttgc gtcagtagca gtgctgatag gattgcggat ttctcaaaga ccggctgaca 488641 gcgatcatcc atacggccat tatcgggctg aaacaatttc gtctcttgtt gcgtctttta 488701 ttatgatggc agtcggcatt gaagtgttaa tcggcggagg aaaagcgatt gcgggcggca 488761 caacggaaac gccaaatctt atcgcggcat ggacggcgtt aggcagtgct gtgtttatgt 488821 atggcatcta tttatataac aaaaggctgg cagcgtccat taaaagctct gccctgatgg 488881 cagcggcaaa ggacagcagg tcagacgctt ttgtaagtgc cggcgcgttt atcggtgttt 488941 tttcgtccca gctgaagctg ccgtgggttg atccggtaac ggcttttatc atcggcatca 489001 tcatttgcaa aactgcgtgg gatatcttta aagacgcttc acattcctta acagacggct 489061 tccatttaaa agatcttgag ccttacaaac agaccgtcgg caggatcgaa aatgtgcatc 489121 gcctaaagga tgtgaaagcg aggtatttag gcagtacagt tcatatcgag atggtgatta 489181 cggttgatcc gaagcttaca gtagaagaag gccatggagt ggcggatgaa gtagaagaca 489241 aaataaaaca tgaacacgat gtcactcatg ttcatgttca tgtagagcct gacgacataa 489301 aataaggctg tttaacgaat tagcttatat gttcagataa aaattcagtc acttcttcag 489361 gcgttttggc attggcgctg tgaaggtgag ctgttttttc accgttcttg aaaataagca 489421 ggctgggaat gcccattact tggtattttt cagccaggtc aggaagctcg tccttattca 489481 gctcatacca gtcgttttgg ttgtattctt ccaaaatatc gccgatgaac atattcatgc 489541 gtgtgcagtc tgggcaccaa tcagcataaa actttacaat gatttcttta tcagattgaa 489601 tcagttcatt aaattgttcg tttgttgtga tttttttcat atgtcacatc tccttttcaa 489661 tgccatttta atataaaata aaaaggaatt acatacaaat gcattcaaca tcagcatgcc 489721 caaaaataat tagatcattt tccggtgaaa atgataagat agtaaagatg aattgtagtg 489781 gggggagtat ccattgaaaa caagtctagg attagtgtac ggaggaaagt cggcagaaca 489841 taatgtttcc ctgcagacag ctctggctgt aatcaaagcg ctaaatactg agaagtttga 489901 tatacatccg atttatataa cagaaaaagg cgaatgggtt agaggcgccc gtttaactga 489961 acctgtttca aacgtgaaaa tgcttcaatt tgagcaagga ggcagtgctt tttctccagc 490021 tgccctgaac caggagatgt ttccgcagga agcgtcacag caaaatgaag ccatcgacgt 490081 cgtattcccg ctcctccacg gaccgaacgg agaagacggt acgatccagg gaatgctcga 490141 gctgttgaac attccttatg tcggcaacgg agtgcttgct tcctcagctg gcatggataa 490201 agttgtcatg aaacatttat ttgcgcaggt tggccttgct caggctaaat acgcagcttt 490261 ccttaagaaa gactggactc gttctccgaa agaaagctgt gaggaggttg aacaggaatt 490321 aggctaccct tgcttcgtaa aaccggcgaa cctcggctca agtgtcggaa tcagcaaatg 490381 ccgaaaccgt gaagaactgc aaaaagcgtt tgagcttgct ttccaatatg accgcaaagt 490441 cgtcgttgaa gaaggaatta acggccgcga gatcgaaatc ggcgttcttg gaaatgatga 490501 tcctaaatgc tctgttgtgg gagaaatcgc accgaagaca gatttctacg attacaaagc 490561 gaaatatgag gatggagata ctgatctgat gattccggcg attgtgactg atgaggaata 490621 cgcaacaatc agtgatatgg cgatcaaagc gtttaaagcg atcgacggtt caggactcgt 490681 cagagcggac tttttcctga cagctgacgg cgaagttctg atcaatgaag tcaacacaat 490741 gcctggcttt acacctttca gcatgttccc gttgctctgg aaagaagccg gagtggaata 490801 tgctgacctg attgaacagc ttgtggagct tgcaaaagaa cgccacgctg aaaaacaatt 490861 gattaagcat acattctaat gaagaaggac actgccggta aaagggcagt gttttttccc 490921 gtatatacaa aagaaagaga gggaccttac ttgattaagc gaacagtaaa aaacattgcc 490981 gaaatggtta aaggcacact agcaaatccg caatatgaac aaacagtcat tcatggagtg 491041 gcaaccgata caagaaaact ggaacaacat cagctcttta ttccgctgaa aggggaacgt 491101 tttgacggcc actcttttgt ggagcaggcc tttgaagctg gtgtagcggc tgttctttgg 491161 gatcggtcag taccaaatcc gcccgagaat cacgccgtca ttttagtgga cgataccctt 491221 actgcacttc agcagcttgc aaaagcttat ttgcaggagc ttggcacgcg tgtcatcgga 491281 gtaaccggaa gcaatggcaa aacgacaaca aaagatatga ttcacgccgt attggggacc 491341 cagtaccgtg tccacaaaac tggaggaaac ttcaataatc atatcggttt gccgctgacg 491401 gttttagcga tgcctgaaaa tacggagatc gccgtattgg agatgggaat gagcgccaaa 491461 ggagaaattg acctcttgag ccgactggca aacccggatg cggcagtgat tacgaatatc 491521 ggcgaatcgc atatgcaaga cctcggctct agagagggca tcgcggaggc gaagcttgaa 491581 atcataaacg ggcttaaaga agacggagtg ctgatttata tcggggacga accgcttctt 491641 caaaatgcat acagctgcca gacgaaaacg tacggtacgg gaacgcataa tgattatcag 491701 cttcaggatg tcagccagag tgaggaagga acccatttta caatcaaagg gatagaaaac 491761 acgtttttta ttccaatact cggcaagcac aatgtgatga acgccatggc tgcaattgct 491821 gcaggggctt attttggcat cgcgcctgag gatgcggcaa aaggactgag cggcctaaag 491881 gtaaccggga tgaggcttga actcatcaaa acagacagcg gcctttcgat aatcaatgac 491941 gcttataatg cgagcccgac ttccatgaaa gctgcaattc aattgacaga aagccttgaa 492001 ggctacggca aaaaaatgct cgtgctcggt gatatgcttg aactcggcga tcttgaagaa 492061 acgttccata aagagtgcgg cgctgtgatc agccctgata aaattgaccg cgtctttacg 492121 tacggaaaac tgggagcttt tatcgcggaa ggcgccctga aacactttga gaaagaccgc 492181 gtcagccatt acactgagaa aaaagatctc cttcaagctg tgaaggaaaa cgcatcaaaa 492241 ggcgatttga ttttattcaa agcgtccaga ggtatgaagc ttgaagaaat cgttaaagat 492301 ttaatagaga gcccgctttc ataagaaaat attttgcgaa aaaacgcata ttgcatcata 492361 aaataacctg atatgcaaac actaatgtat gccggccgaa aattatgtat atctggccgg 492421 ctgcggctat gatacaatat atataggtta tttcgcgata cgaacatatt cgtccggact 492481 tttcatcgtg acccgaagtt ctccgctgga ttcttgggag cggatggagc agcagccggc 492541 atattcgaga tgccgatctg cttctcatct tattgaaaaa caaatagtgt aatggtaaga 492601 taaaacttaa agtaattcgg gctttgtata cggatggatc ctgtccttct tgtctaaagg 492661 gcagttttat aagtggtaaa tcacgacatt actgaaacag caattagaag gagtttgaat 492721 aatttgacta taacgtttca agattttaat ttaagttctg atctcatgaa agcaattaat 492781 cgtatgggat ttgaagaagc aacaccgatt caggcacaaa cgataccgct cggactttca 492841 aataaagacg tcattggaca agcgcaaaca ggtacaggta aaacagctgc gtttggtata 492901 ccccttgttg aaaaaattaa ccccgagtct cctaatattc aagcaatcgt aatcgcgcca 492961 acccgtgaat tagccattca agtatctgaa gaattgtata aaatcggaca agataaacgt 493021 gcgaaggttc ttcctattta cggcggacag gatattggac ggcaaatccg ggcgttaaag 493081 aagaatccga atattattgt cggaacacct ggacgtcttc ttgaccacat caaccgccgc 493141 accattcgtt taaacaatgt aaataccgtt gtaatggatg aagcggatga aatgctgaac 493201 atgggattca ttgacgatat tgaatctatc ctttcaaacg tgccaagcga gcatcagaca 493261 cttctgttct ctgccacaat gcctgcgccg atcaaacgca ttgcagagcg cttcatgact 493321 gagccggaac acgtaaaagt aaaagcgaaa gaaatgacgg tttctaacat tcagcagttc 493381 tatttggaag tgcaagaacg taaaaaattc gatacactga ctcgccttct tgatattcag 493441 tctcctgagc ttgcgatcgt attcggacgt acaaaacgcc gtgtcgatga gctggctgaa 493501 gctctgaacc ttcgcggata tgcagctgaa ggtattcacg gtgacttaac gcaggcgaaa 493561 cgtatggttg cgcttcgtaa atttaaagaa ggcgcaatcg aagttctagt cgcaactgat 493621 gttgccgctc gcggacttga tatctcaggt gttacacacg tatacaactt cgacgtgcct 493681 caagatcctg aaagctacgt tcaccgtatc ggaagaacgg gccgtgcagg aaaaacaggt 493741 atggcgatga cgttcattac accgcgtgag aaaagcatgc ttcgcgcaat tgaacaaaca 493801 acaaaacgca aaatggaccg catgaaggag cctacacttg atgaagcgtt agaaggtcag 493861 caacaggtta ctgttgaacg tcttcgcaca acaatcagtg aaaacaacct gaacttctac 493921 atgacagcgg cagctgagct gcttgaagat catgatgcag taacagtggt tgcggcggct 493981 atcaaaatgg ctacaaaaga gccagacgac acaccggttc gcttaacaga cgaagcgccg 494041 atggtcagca aacgctacaa gaaccagcgc tcttctaaac gcagagacgg tcaaggcggc 494101 ggctaccgcg gcggaaaagg gaaaagcaac aaccgttctt cctatgacaa aaagcgttca 494161 aacgatcgcc gttcttcagg tgacagacgc cagaaaaaat cttactaatt tgatcgattc 494221 agagcccaaa acatgatgtt ttgggctttt ttatgttcgt gatttgttat tcagcaaact 494281 ttcagctgac ggaagccatt tttctctgta tgcttaagaa tgaaaccttt ctgtaaaaga 494341 gacgtataaa taacgacgaa aaaaagggag gtaggtattt ttgagagagc agccaaaaaa 494401 ccaaatcagt ccagacggat taaaggtttg gcgacttcaa gagatcatca tatccgctgt 494461 ttgcttgctt attgtcattg cagttgcagt gttaagctat tattttcatt ggccgtactg 494521 gatcagcggc gtgctcggcg ctgtttggct gctgggatcg attgtgacgg tctttatcat 494581 tccgaaggtc cgtcataagg tgtggcgata tgaagtccat gaacatgaaa tagatattca 494641 gtcaggtatt tttgtggtga cacgtgtgat tgttccgatg gtcagagttc agcacgtcga 494701 tacgtcacaa gggccattat taaaaaaata caacctggca acggtgaaaa tttccacagc 494761 cgcgaccgtt cattcgatcc ccgctttaga gatggaggaa gcggatcggc taagagactc 494821 catttcccgt ctggcgaggg tgactgacga tgatgtctga accgaaacgc ctgcacccgg 494881 tggcagtcat tttgaattta tgccatacca ttattcaaac gataaaaaat atcattctgc 494941 cattcttttt tgtgtatatt gtcaattcaa accatactgt ccgtttttac ggagccattg 495001 cgctcggtgt gctgttcatc tggcttgtag cggcaagcat tatcaaatgg agaaggttta 495061 cctatcgaat tgaagatgat gaatttagaa ttgaagaagg cttatttgtt acgaaaaaac 495121 gatacatatc gattgatcgg attcaaacaa tgaatacgag cgcgggcctt gtccagcaaa 495181 tctttaagct tgtgaagctg caaattgaaa cagcaggcgg aggcaaggag gcagaagccg 495241 ttctttctgc tatttctgtt gaagaagcgg aacgcatcaa agaagctgtc tttaagaaaa 495301 aagcgcaaag acgagaaaat gaacttgatg aagaacggct tgaagctgaa gaggagttgg 495361 atccgtccgt tgaggtgcaa gagcactatc gcatgaacgc gaaagaattg ctcatggccg 495421 cttctacctc cggcggaatc ggagtcatta tctccgctgt atttgcactt atttcccagc 495481 ttgatgaagt gctgccgatg gattggttat tcgataaatt ttccttcctt cagcacgcca 495541 gcatcggtat ttatgcggta ctcattttta tcggtttatt tatcgcctgg attttcagca 495601 tcgcgggcat gatgtttaga tacgcgaact ttcaaatcat aaaaaaagag caggaactgg 495661 tgatttcaag gggaattatt gaaaaacatc aagtcacgat tccgctgcga aaaatacaag 495721 ccattaaaat caaagaaaat atcattcgcc agcttttcgg ctttgtaacg gtgtccatcg 495781 tcagcgcagg aggcggcgac cgggaaaaag aagaaggcgc tttgaccatt ctctttccaa 495841 tgattcataa aaaaaagctt ccgcacatgc tccgaacatt tacgccggaa tacacgctgg 495901 aagaaaactg ccgccgcctg ccgcggcgcg cgttgaaacg ctatttgttc cgttctgtca 495961 ttttttcact ctttttgatc atcccgttat gtatcttctt tcagccatgg ggctatctgt 496021 cagtgatcct gctgccgata gaattgctct tcggctatct cgcgtataaa gaggctgcat 496081 ggacgatcaa cggggaccgt cttcagctga cgtctagatt tataggcaga acaaccgcca 496141 ttgtactgaa aaaacgaatg caggtctgca agttcagcca atcctatttc caaaagaaag 496201 gccgcttgta taccatttct acttcggtga aatcatcgag ccatatggaa gagttaacgg 496261 tgagggacgt aggtgaagag gatgcagcct tcattttaaa gtggtactca tatgaaaaag 496321 cggacggtta ataccgccgc tccagcgtgt cggcaaaccc tcgcattcgt tgtcaggact 496381 gcgcttcggt gctcaatgcg aagtggatca acggctaaat tctcaggcgt cctgcctaaa 496441 cgccgtcgtc atcacatcct gtgaaagtcc gctcctatgc tcgtccttcc tagacttcat 496501 gggttttcaa tcacgctgaa aagatgacaa aatcctaaaa tgaaaaccat tttaggattt 496561 tgtcaacaat ctgaagcggc ggttaatacc gccgctcttt tttttgcacg cataaaaacg 496621 aaagaagaaa cccgccgcat agtccaaaca aatgggccat catgttaata ttggagttga 496681 taaacgacat gagaacggca aatgcgagca gtgtgatgat cattttggaa tgctcctgcc 496741 caattaactc attgcgaaaa agaaccataa acaggtatac gccaaatagc ccgaaaatgg 496801 cgcctgaagc cccgacatgc acgtaatcaa gcggctctgt aacataagtg ccgatattgc 496861 cgatgatgcc ggagccggcg tatacaagaa ggaaacgcgc ttttcccagc atgcgttcca 496921 aagccggggc aaataaaaag atggacatgg aattaaacag cagatgtgtg aaaccggcgt 496981 gcagcaaaat cggtgtgata agccgccacc attcaccgtt tgcgacacct agattatagc 497041 ctgtgacggt atccctccat aacacgactg aatgggcagg aagtgaaaaa aacagccaga 497101 gaacagcttg caaagccaat ataaaggtga caacggggta aagcctgata aatgtttgaa 497161 aattttcagt ccgtataaac attccgagcc ccttttcttc attttggtat atctatagta 497221 acacgtttat gagacaaacc atttaaatag tacgtacgca aaggaggtta tcatacatga 497281 tttacggcat tgggctggac attaccgagc ttaaacggat cgcctctatg gctgggcgcc 497341 agaaaaggtt tgccgagcgg attttgacgc gaagcgagct tgaccaatac tatgagcttt 497401 cagagaaaag aaaaaacgaa tttctcgcgg gcagattcgc ggcaaaagaa gcgttctcga 497461 aagcatttgg caccggcatt gggaggcagc tcagctttca ggacattgaa attaggaaag 497521 accaaaatgg caagccctat atcatttgta cgaaactgag ccaggccgcc gttcacgtat 497581 cgatcactca tacaaaagaa tacgctgccg cgcaggttgt gattgaaagg ttgtcaagct 497641 agtctgcata ttagggaaac cccactcata tatttgatag tgcattaagg gagacaagtt 497701 gtttgaggct tttatggtac gcatctgttc tgcctaaacg tgtaccgagc gtaccgttaa 497761 agtcaaacaa gcgatttctt ccttttacat caattgagaa aaaggggttg aaaaaggtga 497821 gaaaaagctt tgttttgctt ttaacgggac tgcttgctgt tcttattctt tctgcctgcg 497881 ggcaaaaaac acagcaagat attgtggccg ggttagatga aaaggcgaaa gaatacacct 497941 cgtacaaagc aaaagcgaaa atgaccatcg agacagggag tgagcctcaa gtatacaatg 498001 tggaaatctg gcacaaaaag ccgtctctgt acagggttta tttagaaaat ccgaaaaagg 498061 accaaaacca agtcatttta cgaaatgaaa acggagtatt cgttctcacg ccgtctttaa 498121 ataagagctt cagatttcaa agcgattggc cgaacaacag cagccaggtt tatctgtttg 498181 aatcgctcgt aaaggatgtt caaaacgatt cggatgcagt tttcacagcg aaagaaaaga 498241 aatacgtatt tgaaacaaaa acaaactatc agcataacaa aatgctgccc acgcaagaaa 498301 tcacatttaa caaaaaagat atgagcccgt catctgtcaa agtgatggat actgaccgga 498361 aagtgatggt caaagtagaa ttcagcagct ttgaatttaa taaacaattt gataaagaat 498421 catttgatga aaagaaaaat atgacccttt ctcaaatgga tgtcgccaca agcgcaaagc 498481 cttccgatac atttgcggtc aaaacgccgc tggaactgcc gcttggcgtc aagctgcttg 498541 aagaaaaaga tatatctact gaagacggga agcgcatcat catgacgtac ggaggagaaa 498601 aatcatttac gttaattcag gaaaaagccc agattgccaa ggcttcctcc tccgttacgc 498661 tgaacggcga accggtaaat ctcggctaca ccatcggcgc cctgtcggat gcatcattat 498721 catggacata tgacggcgta gattaccttc tctcttctaa agatctttct aaagaggaaa 498781 tggtgacagt agcgaaaagc atgcagggac aatcatcgaa ataaccgcca aaggccaaac 498841 atgatttggc ctttttttcg ttagacatcg tttcccttta gcctttaatt ttagtatgat 498901 atgtaaatga tattgaataa aagctaggaa gtgtcgtaat gagcacaaaa cctttttaca 498961 gagatacgtg ggcggaaatt gacttgtccg cgataaagga aaatgtcagc aatatgaaaa 499021 aacatatcgg tgaacatgtc cacttgatgg cagttgtgaa agcaaacgcc tacgggcatg 499081 gtgatgcaga aacagcaaag gctgctcttg acgcaggtgc ttcatgcttg gccgtggcca 499141 ttttggatga agcgatttca ctgcgcaaaa agggattgaa ggcgcctata ttggtgcttg 499201 gcgcggttcc cccggagtat gtggcaatcg ctgctgagta tgacgtgacc ttaacaggtt 499261 attctgttga atggcttcag gaggcagccc gccacacgaa aaaaggttct cttcattttc 499321 atctgaaggt cgatacgggg atgaacagac ttggtgtaaa aacagaggaa gaagttcaga 499381 acgtgatggc aattcttgac cgcaaccctc gtttaaagtg caaaggggta tttacccatt 499441 ttgcgacagc ggatgaaaaa gaaagaggct atttcttaat gcagtttgag cgctttaaag 499501 agctgattgc tccgctgccg ttaaagaatc taatggtcca ctgcgcgaac agcgccgctg 499561 gactccggct gaaaaaaggc ttttttaatg cagtcagatt cggcatcggc atgtatggcc 499621 ttcgcccgtc tgctgacatg tcggacgaga taccgtttca gctgcgtccg gcatttaccc 499681 tgcattcgac actgtcacat gtcaaactga tcagaaaagg cgagagcgtc agctacggag 499741 ccgagtacac agcggaaaaa gacacatgga tcgggacggt gcctgtaggc tatgcggacg 499801 gctggctccg aaaattgaaa gggaccgaca tccttgtgaa gggaaaacgc ctgaaaattg 499861 ccggccgaat ttgcatggac caatttatgg tggagctgga tcaggaatat ccgccgggca 499921 caaaagtcac attaataggc cggcaggggg atgaatatat ttccatggat gagattgcag 499981 gaaggctcga aaccattaac tatgaggtgg cctgtacaat aagttcccgt gttccccgta 500041 tgtttttgga aaatgggagt ataatggaag taagaaatcc tttattgcag gtaaatataa 500101 gcaattaact tacctaaatg gagaattcat aaaacagctt tgcttgaaga gtgaataatg 500161 gtatcattat cactggatgg ataaaagagt cgtatccgta agtttggtgg aggtgtatgt 500221 tttttgtctg aatccagcgc aagaaccgaa atgaaaatca gcttgcccga aaacctagta 500281 gctgaattgg atggtgtagc gatgcgggag aaacgaagca gaaacgaact gatatcacaa 500341 gcagtgagag cgtatgtcag cgaacgaaca actcgtcaca accgtgattt gatgagacgc 500401 ggctatatgg aaatggcgaa aatcaacctg aatatttctt ctgaggctca ctttgcggag 500461 tgcgaggctg aaacgacagt tgagcgctta gtcagcggag gataatcatt tgattgtgaa 500521 acgcggcgat gtttattttg ctgatttatc tcctgttgtt ggctcagagc aaggcggggt 500581 gcgcccggtt ttagtgatcc aaaatgacat cggaaatcgc ttcagcccaa ctgctattgt 500641 tgcagccata acagcacaaa tacagaaagc gaaattacca acccacgtcg aaatcgatgc 500701 aaaacgctac ggttttgaaa gagattccgt tattttgctg gagcaaattc ggacgattga 500761 caagcaaagg ttaacggata agattactca tctggatgat gaaatgatgg ataaggttga 500821 tgaagcctta caaatcagtt tggcactcat tgatttttag acatatttgc aggttgctca 500881 aatagagcaa ctttttttgt tttcaaaaaa cataaacgat ataatagtga aataacgaaa 500941 aaatatgttg ttttttattg ggaggtaagc gaatttgatg tcgaaccaga ctgtatacca 501001 gttcattgcc gaaaatcaaa atgaactgct ccaactgtgg actgacacac taaaagaatt 501061 aagcgagcaa gaatcctatc agctgactga ccaagtgtat gaaaatatat ctaaagaata 501121 tatcgacatt ctgctgctgt ctgttaagga cgaaaatgct gctgaaagcc aaatcagcga 501181 actggcgctt cgagcggtcc aaatcggact gtctatgaag tttttggcta ctgcacttgc 501241 cgaattctgg aagcgtctct acacgaaaat gaatgataag agattgccag atcaagagag 501301 cacggaatta atctggcaga ttgatcgctt tttcagcccg attaacacag aaatttttaa 501361 tcaatactca atctcatggg aaaaaacagt atccctgcaa aaaatcgcgc tgcaagagct 501421 gtctgcgccg cttatcccgg tgtttgaaaa tatcactgtg atgcctcttg tcggaacaat 501481 tgataccgaa cgcgcgaaac gaattatgga aaaccttctt aatggcgtcg tcaaacaccg 501541 ttcccaagtc gtgctgattg acattacagg tgtccctgtc gtcgatacga tggttgccca 501601 tcatattatt caggcatcag aagctgtaag gcttgtcgga gcaaaatgcc tgctggccgg 501661 aatccgtccg gaaattgctc aaacaatcgt caacctgggg attgatttat cccaagttat 501721 aactaagaat accctgcaaa aaggaattca aacagcattg gaaatgacgg atcgaaaaat 501781 cgtttcattg ggggaataac attttgagac atccgaaaat cccgatcttg aaactgtata 501841 attgcttatt agtgtccatt cagtgggaac ttgatgacca gacagcatta acttttcaag 501901 aagacttatt aaataaaata tacgaaacag gtgctaacgg agtcgtcatt gacctgacat 501961 ctgtggatat gattgattca tttatcgcga aagtgctggg ggacgtcatt acaatgtcta 502021 agttaatggg ggctaaagtc gtcttgaccg gcattcagcc cgctgtggca gtgacgctga 502081 ttgaacttgg aatcgcgctt gaggaaatcg aaactgcgct cgacttagag caggggcttg 502141 agacattgaa gcgggaattg ggggaatagc gaatgaacga ccaatcctgt gtaagaatca 502201 tgacagaatg ggatattgtg gccgccagac agctgggacg aaacgttgcg aaagaactgg 502261 gtttcggcac ggtagaccag gctagaatta caacggctat ttcagaatta gccaggaata 502321 tttatttata tgccggcaaa gggcagattg gaattgaaca ggtcgcagac agaggaaaaa 502381 aaggcctgaa aatcatagcg gaagaccaag ggccgggaat tcctgatatc cgaaaagtca 502441 tggaagacgg gttttcaacg tctggaggac ttggtgcggg acttcccggg gtcaaaaggc 502501 tgatggatga attcagctta aattccgtag cgggggaagg aacagagata caagccatca 502561 aatggcttcg gtaggaggta agaacgtgga ttttagggag gttattgagc agcggtatca 502621 tcagctgctt agtcgatata tagccgaatt aacagaaaca tctttatatc aagcccaaaa 502681 attcagccga aaaacaatcg agcaccaaat tcctccggaa gaaatcatca gcattcacag 502741 aaaagtgctg aaggagctgt atccaagtct cccggaagat gtgtttcatt cgctggattt 502801 tttaatagaa gtcatgattg gctatggaat ggcttatcag gagcatcaaa cccttagagg 502861 gatacagcag gaaatcaaat cagaaattga aatcgcggca aatgtccagc agacgcttct 502921 cggaactaaa gttcctcagg aggaagcgct ggatatcggc gccatcagtg ttcccgctaa 502981 acagatgagc ggtgattact accactttgt caaagacaag gaatccatca atatcgcaat 503041 cgcggacgtg atcggaaaag gcattccagc ggctttatgc atgtccatga ttaaatacgc 503101 aatggactct ttgccggaaa cgggcataca cccttctcaa gtgctgaaaa atttgaatcg 503161 tgttgttgaa caaaacgttg atgccagtat gtttattacg atgttttatg cgaattacaa 503221 tatggacaag catcaattta catatgcttc agcgggacat gaaccgggat tctattattc 503281 tcaaaaagac aacacgtttt acgatttaga ggccaaagga ctcgttctcg gcatctcgca 503341 ggactatgac tacaaacaat tcgatcagca tctggaaaag ggcgatatga ttgttttatt 503401 ttctgacggc gtcacagaat gcagaacgga aaacggtttc ttggagcgtc ctgatctgca 503461 gaagctcatt gaggaacata tgtgttcctc tgcgcaggaa atggtcaaaa acatttatga 503521 cagcctcctc aaattgcagg attttcagct tcacgatgat tttacgttaa ttgttttgcg 503581 gagaaaggtt taacgtctgt cagacgaggg tataaagcaa ctagtgattt gaaggaaaat 503641 ttgaggtgat acgaatgaat ataaatgttg atgtgaagca aaacgagaat gatatacaag 503701 taaacattgc aggagaaatt gatgtatact cagccccggt gcttagagag aagctcgttc 503761 ctctggcaga acaaggagct gacttaagaa tttgcctgaa agatgtcagc tacatggaca 503821 gtaccggatt gggcgttttt gtagggacct ttaaaatggt gaaaaaacaa ggtggttcgc 503881 tgaaacttga aaatctttct gaacggctga tccgactgtt tgacattaca ggcttgaagg 503941 acatcattga tatttctgca aagtcagaag gtggagtgca atgaagaata atgctgatta 504001 catcgaaatg aaagtgccgg cccaacctga atatgtggga attataagac tgacgctgtc 504061 aggggtcgca agcagaatgg gctatacgta cgatgaaatt gaagacttga aaatcgcagt 504121 cagtgaggcg tgcacaaatg cggttcagca cgcttacaaa gaagataaaa atggggaagt 504181 gtcaatacga ttcggtgtgt ttgaagaccg tttagaggtt attgtggcgg atgaaggaga 504241 cagctttgac tttgatcaaa agcagcagga tctagggccg tacacacctt cgcacacagt 504301 tgatcaatta tcagaaggag ggctcggtct atatttaatg gaaacgctca tggatgaagt 504361 cagagtgcaa aaccactccg gcgtcaccgt agcgatgaca aagtatttaa atggggagcg 504421 agttgatcat gacacaacca tcaaaaacta cgaaactaac taaagatgaa gtcgatcggc 504481 tcataagcga ttaccaaaca aagcaagatg aacaagcgca ggaaacgctt gtgcgggtgt 504541 atacaaatct ggttgacatg cttgcgaaaa aatactcaaa aggcaaaagc ttccacgagg 504601 atctccgcca ggtcggcatg atcgggctgc taggcgcgat taagcgatac gatcctgttg 504661 tcggcaaatc gtttgaagct tttgcaatcc cgacaatcat cggtgaaatt aaacgtttcc 504721 tcagagataa aacatggagc gttcatgtgc cgagacgaat taaagaactc ggtccaagaa 504781 tcaaaatggc ggttgatcag ctgaccactg aaacacaaag atcgccgaaa gtcgaagaga 504841 ttgccgaatt cctcgatgtt tctgaagaag aggttcttga aacgatggaa atgggcaaaa 504901 gctatcaagc cttatccgtt gaccacagca ttgaagcgga ttcggacgga agcactgtca 504961 cgattcttga tatcgtcgga tcacaggagg acggatatga gcgggtcaac cagcaattga 505021 tgctgcaaag cgtgcttcat gtcctttcag accgtgagaa acaaatcata gaccttacgt 505081 atattcaaaa caaaagccaa aaagaaactg gggacattct cggtatatct caaatgcacg 505141 tctcgcgctt gcaacgcaaa gctgtgaaga agctcagaga ggccttgatt gaagatccct 505201 cgatggagtt aatgtaatga tccaggttga agaaaacgag catattcaaa ctctagtata 505261 tcaactgaat aaagaaggga aatcgatttg cggtgacagt ttttttatga aagctgatga 505321 taaggagtta atttgcgcgg ttgctgacgg actgggaagt ggatcacttg ctaacgaatc 505381 ctctgcagcc atcaaagact tagtggaaaa ctatgcgagt gaagacgtag aaagcattat 505441 cgaacgctgt aatcaggcga tgaaaaacaa aagaggcgct acagcatcta tcctgaaaat 505501 caattttgag caaaggcagt ttacgtactg ctctgtcgga aatgtacggt ttattctgca 505561 ttccccgtct ggtgaaagct tttatcctct gccgatttcg ggctatttat caggcaagcc 505621 gcaaaaatac aaaacgcaca ccgccaccta tgaaaagggt tcaaagttca ttatacatac 505681 agatggactc aacgtacctg atatccgctc ccatttgaaa aaaggccaat cggtagaaga 505741 aatatcgaat tcgctgaaaa tgtatacgac atcgagaaaa gatgacctga cctatattct 505801 cggacagctg tcctaaaaaa ccagaaaaag aagctggaca tccggcttct tttttttgcg 505861 gttgactatt aataagtgcg cttattatac ttaataagtg aacttatcat tctgggagct 505921 tatgggatgt ggaattatga atacacagcg atagctgatg tggatgtggg aaaacctgga 505981 actgttatca ggaaacagaa acaatggatc aatgggagac gggtattgca tcagattctt 506041 tgaaaggaca atttcaaaat ggaacggaag gaacattgct tctgcaagga aaaacaattc 506101 tcttatggct tgagcatgtg gagaaacatc gggcgttttc tgtcatggtc aacatgcccg 506161 catagcaatg taataatgga gttttttcac gtgcttcaaa agcaaaaaga agatttgtgt 506221 atcacatatg gaattgtatt agaaggcgct gaagcaaaaa agtggggaga aatcattggg 506281 actgaactgt ctaaagacat gccgacggct gtcagcaggc ttgtccatct ttacggagga 506341 gtgataaaat gaacacaaat tactggatcg gcgttgtgtc agagcaacat gtattaaaag 506401 gcgctgccgg cggttttgca cagctgtgcc atggaaaaaa agccccgctc gccaaaatga 506461 aagagggaga ttggctgatt tattattctc cgagagacgc atatccagac ggcaaactgc 506521 tgcgaagctt tactgcgatc ggcaaagtaa aaagcggaaa catctatccg tatcaaatgg 506581 ctccgaattt tattccatac cgattagata tagactatta tccatgccat aaaatcggtt 506641 tttacgacat taaatcaaag cttgaatttg ttcaggaaac caagcatctt ggctttttat 506701 ttcgcagagg acactttgaa ataagcaaaa aagatttttt gacaatagca caagcgatgg 506761 gagttaacat aagtggaatg gcactctaaa tttagcggtc cgaacacaag cccgggcttt 506821 ttattatggc aggccacgca aagttggcag cggaaagtag gaaaagcatt ggctgagttt 506881 gacctgaccc acgttcaatt tgttctgctg acctcgtgca agtatatgat tgctcacgga 506941 gaaaccgtca cgcaaaaaaa acttgcaagc ttcagccaga ccaatatcat gatggtttcg 507001 gaggttgtgc ggacgcttga gaaaaaagga tttatcgaaa gaagcaaaaa tccccaggat 507061 aaaagagagg tcctcctgtc tcttacagaa ataggaggag aaaaagtaac agcggctttg 507121 ccaattgttg agaagattga tcaagccttc tttgcagctg cgatgaaaaa agagaatttt 507181 ctgagcggct tacaggaact attgaaacat gagtaaagat acgggcagcg ccagctgtct 507241 ttttttatgt gtttttttcg gtttttgata cactagagaa agaacgacaa aattggaggc 507301 tttggttaca tggaaacgtc agccctttta aaacagcaaa ttgcgaaaga aataggttta 507361 tcacaaaaac acgttgaaag tgtcatccgc ctgcttgagg acggcaatac agtcccgttt 507421 attgcccggt atcgaaaaga gcagacgggt tcaatggatg aggttcagat tcagacgatt 507481 tctgaacgct ggcaatacat acaaaacctg aatcagcgaa aagaagaagt catcaggctg 507541 attgcagagc aggataaact gacagataat ctaaaacgta aaatcgagca atcggtgaag 507601 cttcaggaag tggaagacct ttaccgccct tataaacaaa aacgtaaaac aaaggcgaca 507661 gtcgccaaaa gcaaaggcct tgagccgctt gccgactata tcctgacact tccccaagat 507721 gatcatctgg cagcaactgc agaccaatac atcagcgaag aaaaagaagt gttcacacga 507781 gaagaagcga ttgaaggcgc caagcacatt attgcggaac aaatctcaga cgagccgacc 507841 ttcagaaagt ggattcgcca ggaaaccttc aaaagaggaa ccattaagtc tgcagccgga 507901 aagtcggcag acaccgatga gaaaaatgtg tatgaaatgt attacgagta tgaagagcca 507961 attgcaaaag ttgttccgca tagggtgctg gcaatgaacc gcggcgaaaa agaagacatt 508021 ttaaaggtag cgatcgaacc gcctgcggat cacattaagg cgtatttaga aaaacaaatc 508081 atcaaaaatc gctcaacatc cgtaagagag attttgcagg agacaattga agacagctat 508141 aaaaggctga tccagccggc aatcgagcgt gaaatcagga aagagctctc agaaaaagct 508201 gatgaacagg cgattcatat tttctcagag aacttgagaa agcttctttt gcagccgccg 508261 atgaaaggca aaaccgttct cggtgttgac ccagcctttc gaactggctg taagctcgct 508321 gtgtcagatg agaccggaaa agtcttgaaa attgatgtga tctatccgca tgcgccagtc 508381 aacaaaacaa aagaagccca tgaaaaagtg aaaaagattc ttgagcagta tcaagtcgag 508441 atggtggcga tcggaaacgg cacagcatcc agagaaacag agcaattcat cgtcaatgta 508501 ctcagagaca tgccgcgcaa aatttattat gtgatcgtca atgaagcggg agcaagcgtc 508561 tattcggctt cagagcttgc cagagaagaa ttccctgacc ttaaggttga agagcgcagt 508621 gccgtatcta ttgctcggag acttcaagac ccgctcgcgg agctcgttaa gatcgatccg 508681 aagtctgttg gtgtcggaca gtatcagcat gacgtcagcc aaaaacgctt aaatgaatct 508741 ctgcggtttg tcgtcgaaac tgtcgtaaac caggttggag taaacgtcaa cacagcctcc 508801 gccgcgctgc ttcaatatgt agctggatta tcgaagtctg tagcaggcaa cgttgtcaaa 508861 aaacgtgagg aaatcggaaa gttttcaaat cgaaaagaac tgaaggacat cccaaggtta 508921 ggtgcgaaaa cctatgagca atgtatcggt ttcttaagag tgcaggaagg gacagagcct 508981 ttggatagaa caggcatcca cccggaaagc tataaagaaa caaaagcact tttgaaaaaa 509041 ctcggacttt caacagaaca tatcggcacg gcggaattga aggacaaaat caatcagctg 509101 gcgctctctg aaacggcaaa agagctggga atcggcgaaa tcactctgaa agacatttgt 509161 gaacagctga caaggccgga acgcgatcca cgcgataagg tgcctaagcc tttgctgaaa 509221 acagacgtcc ttcagctgga agatttgaaa gagggaatgg aactgcaggg caccgtgcgc 509281 aatgtagtgg acttcggagc gtttgttgat atcggagtca aacaagacgg gcttgtgcat 509341 atctcaaaat tgagcaatca attcgtcaag catcctcttg atgtcgtatc tgtcggcgat 509401 attgtgacag tttgggttga cggcgtagat gtacaaaaag gcagagtatc gctgtctatg 509461 gtaaaataaa agcactgctt acgagcagtg ttttttccta tagaaatacc agcattgatt 509521 cagcagttta atttggtaat tatctttttc aaggaacgct ttttgcatct gctttttaag 509581 ccaatttggc ataggctcat tcctcctcag cttttatcat aagagggaca gtgattacca 509641 tattgtatgc gaacggtgaa ttgtcccgtt caatgttttt taagtgaggt gcaccatgga 509701 taacaaagag cttcaaaagc tgacagagga tatttctgaa acatatttta aaaagccgtt 509761 ccgccatcag gcgcttttta atgaccggct taaaaccact ggcggcaggt acctgttaac 509821 ctcccataac attgaattga acagaaaata tttgattgaa cacggcaggg aggaactgat 509881 tggcatcatc aagcacgagc tctgccatta tcatcttcat cttgaaggaa aagggtacaa 509941 gcacagagac agagatttta gaatgctatt gcagcaggtc aacgcgccga ggttctgtac 510001 accccttaag aaaaaagcgg aaaacaaaaa aacttatatg tatatctgta cgacctgcgg 510061 ccaacagtat ataaagaagc gcgccatgaa ccctgacaga tacagatgcg gaaaatgccg 510121 cggaaaaata aaaagaattt tttcgtgaaa aaggttgacg aatatggcaa gcctatgtta 510181 cattataaaa gtcgtcacga gagataaata aaaacattta cctcttgaca ctgcaaatca 510241 aggctgatat aataagtctt gtctcattat tccacagtag ctcagtggta gagctatcgg 510301 ctgttaaccg atcggtcgca ggttcgaatc ctgcctgtgg agccatattg gagaagtact 510361 caagtggctg aagaggcgcc cctgctaagg gtgtaggtcg cgtaagcggc gcgagggttc 510421 aaatccctcc ttctccgcca taagatttcg atataagttc tcaaccatcg gcccgttggt 510481 caagcggtta agacaccgcc ctttcacggc ggtaacacgg gttcgaatcc cgtacgggtc 510541 attccatttc gttgggctat agccaagcgg taaggcaacg gactttgact ccgtcatgcg 510601 ttggttcgaa tccagctagc ccagccattt ttatttttga aatctaatag taagagccat 510661 tagctcagtt ggtagagcat ctgactttta atcagagggt cgaaggttcg agtccttcat 510721 ggctcaccat ttgtcttttt gcgggtgtgg cggaattggc agacgcgcta gacttaggat 510781 ctagtgtctt acgacgtggg ggttcgagtc ccttcacccg cactttattt acaaagtgca 510841 cgcaaatctg ttttactagg ttaagagcct actaaaccag cacaacacaa tttaatgatc 510901 acgcggtcgt ggcggaatgg cagacgcgct aggttgaggg cctagtgggt gaataacccg 510961 tggaggttca agtcctctcg gccgcatctc aataatacca agggtttaac cacctttggt 511021 attatttttt tgtgtggaaa atacggctat gggagaagac ttgctcacca aaactcacca 511081 gttacttaaa gtaagtcatc caaacggtcg gcggttcctt ctgtttatta ggaaaaagat 511141 atccgttcat tgtaaaagaa acgaaccatg tcctattcgt tcaaaaaaac taaagggtga 511201 tacatattat acatgattaa tatgtatcac ccttttcttt cttgttcaac aatcgcgctt 511261 gaggagaaca taagctaata caactgactc gatttctaaa gttgctccat tcttttttta 511321 aacaactcat ccacaacctg ttttaaaatc tcgtacgact gaatttcctt gctcaattcg 511381 taaatattag ataacacaat taattcatct gcgtgataca tttgttggaa atcaattagt 511441 tcgcgacgaa ttgtttctcg atcacccatg attgtatacc ccagtcgact gtggagaatt 511501 tctaattcaa actgtgataa cgattctagg aagttttcag tgggtggaat aagcttactt 511561 aaattatttg tataaatatc aatatacacc tgcaaatgac ttgcagaaat aaaagatgcc 511621 tcgtctatag attctgctgc aatcacatta atgcaagcga tcacataagg ttcttgtaaa 511681 taagaagacg gttggaaatt ttctcgataa atagagagcg cttcttccat cgaatggggt 511741 gaaaattgag cgccaaatgc atagggtaaa ccaagctttg cagcaatttc cgctgaatcc 511801 gttgaggatc ctaacacaaa aacaggcaca tgcgttccaa tacccggata agcgcgaacc 511861 tcaccctgta cactcttatc cccgacaaaa cgcaaaatat catttacttc tctttcaaag 511921 aaaaacactc cattatggtt ggaacgacga atcacatcgg ccgttttttg atccgttccg 511981 ggtgcgcgtc ctaatgccaa atctacacga tttggatata atgtttcaag tgttccaaat 512041 tgctccgcta cgattaatgg ggaatgattt ggcaacataa taccccctga acctacgcga 512101 atgtcttttg tatttgctaa tatatgttgt acaattgata cggttgctgc acttgcataa 512161 gcgtcgtgat tatgatgctc tgcaaaccaa atccgtttat agcccatatt atctacagct 512221 ttagctaatg acactgcaga atcaatccct tgtttcattg tttctccttg tcttaatgga 512281 gcaactgata aaacagatat atcaaatttt ttcataattt cacctctaaa ataatgaact 512341 tatacaagat caatggaaaa aacattttga aaaattgttt catattaaat ggtgtccatt 512401 cctctttgat ttgcatgcaa ataaatatat actttctcaa acgatcaata cataggcaaa 512461 ataaagttat ttcacaattt cactttactt ttaaagtttt aagcaaacat aaaaaaatgt 512521 tcagtgaaca aaatatgtaa aatacatctt atttttcaga aaggatacaa gaaaatgatt 512581 gatgaaatag ataaaaaaat acttgatgag ctgtctaaaa atagtcgcct tacaatgaaa 512641 aaattagggg aaaaagtaca tctcactgca ccagcaaccg catcaagagt agtaaagtta 512701 atagacaatg gcataataaa aggatgtagt atcgaagtga atcaagtgaa attaggcttc 512761 tctatacatg cttttcttaa tatttatatc gaaaaaatcc atcatcaacc ctatttagct 512821 tttatagaaa cacaagataa ctatgtaata aacaattata aagttagtgg agacggttgc 512881 tatttgcttg aatgtaaatt tccttcaaac gaggtattag atcaattttt aaatgactta 512941 aataaacatg caaactataa agtgtcgatt gttattggta aatagttaac tttataaaac 513001 ggagatgtgc ggtcatataa catgatatat atgctctaaa aaagccctag gttggatatg 513061 gaatttacca agctggggcc tttttataca ttataataac aagcgcatta ttcatcagac 513121 attaatgaag tattataatg cttttttact tccttaatag acaaataaag ctgatagttt 513181 ccatacttca ataaatcatt cagaaggtga tttaaaactt cttgtgaatg aaccgttacc 513241 ttcagaagat aacatgcatc tcccgaaaca cgatgagctt cgctaatttc attacgagta 513301 gcaataaatt tcaataaatc atcatgcata tatgcattca tgaaaaagaa gacaaaggct 513361 gtaaaagaaa accccatctt caattcatca accacaatcg aatatgcttt aatgataccg 513421 ttatcctcca tttttttgat gcgattgcct accgcttgtc ctgtcatatg aattttttca 513481 ccgatttctt tccattgtat ccgagcattt ttatttaata attggagaat ttgaaaatca 513541 attgaatcaa tttgcatagt aactcctttc acagtgaaaa agttttacaa aatagtattt 513601 catgagacca tcgaaaattc aatggaaatt atatatcctt atacagtata aaaattttaa 513661 gaggtgaaaa aatgacaaca gctttattag tgattgatat tcaaaatgat tactttccaa 513721 atgggaagat ggctttaaca aacccagaga aagcagcaca aaatgcggct aaactacttt 513781 cacactttag aaacacaggc gcacctgtct ttcatgtaca gcatatcaca gaaggtaaca 513841 tcgctcattt tttccatcca aatacagaag gtgtcgaaat tcatgagtca gtacgtccat 513901 tagagaaaga gacagtcatt gtaaaacata tgccgaatag ctttttcaat acagatttaa 513961 atggaaagct acaagaagaa ggggttaaag aattagttgt ttgcggtatg atgtcccata 514021 tgtgtattga tgcaacagtt cgttctgcag ttgaacatgg ttatgtatgc caagtggtag 514081 aagatgcttg cgcaacaaca acattgcaaa ttgaagataa aatcgttcct gctgagcatg 514141 tccattacgc atttatggcc gcattaaatg gtgtctatgc aacagtaaaa accacagagg 514201 catttttaaa ataaaagaat ttcctgcgcg aacataacgt ctttcttttc acaagaaaga 514261 tgattcaaca acttaaaaaa ggatgttcag aaaaatactt ctggacatcc tttattcatt 514321 atcttttatt gtttttcagt atcattattc ccatctgata aaagatcaag atgtcctgtt 514381 tttgatccat agtaagacca tatacaggga ttgtttttgc cataaatata gatattgatg 514441 aaggtttaca taaagcacct aattgcttga tttactttaa tgttagatcc ctcaataact 514501 ccattctctt ctaatttctc tactctagct gtagctgctg ggcatgttaa atgtactctc 514561 tcccagatct ttcattgaat tcggctatta tacataattt ctctataatt ttttatctgt 514621 ttgatctatt tgaacgttaa ttcctttcga aaataaagtc aaagagttaa aacacttttt 514681 tttatctatg tattcgaaca ctgctgatat tatacactta actctgtcga tctaagacaa 514741 ataaaaaaag aaagtgagtt gtaaatatga atattacaca aattcgaaat gcaacaattg 514801 ttgtaaaata cgcaaataaa aaatttttga tagatcctat gttagcagag aaaggtacgt 514861 acgctacttt ccctgaaacg atcagacaag atttatttaa tcctttggtg agtttgccaa 514921 catcaattga taacattctg gatggcgtag atgcggtaat tgttactcat ctacacctag 514981 atcactttga tgatgtggca aaaaacgtat tgccaaaaaa catcaaaatg tttgttcaaa 515041 atgaagcaga tgcaaaagaa gtaaaagcaa gtggtttcaa aaatgtagaa gtgctacatc 515101 aagacactgt ttttgaaggg atccaattag taaaaacaaa aggtgaacat ggcagagggg 515161 aagagttatt aaacttaatg ggtgatgttt gtggattagt attcaagcac ccaagtgaaa 515221 aagttttata tgtagctggg gatacagttt ggtatgatgc tatcgaagac gagattcata 515281 cacatcaacc agaaatcatt gtggttaatg gtggagacaa tcaaagatta gatttaggtt 515341 cactcatcat gggaaaagaa gacatctatg aagttcacaa ggctgctcct catgctaaga 515401 ttatatctgt tcatatggaa gctgttaacc attggacact atctagagaa gaattaaaaa 515461 actttagtaa agaaaaagga ttctcaagta atattttagt gccagaagat ggcgagtctt 515521 acacatttta atatgaacac cgacaaataa atagaagaag ctcataatta taaaaactaa 515581 tcatgagctt cttctaataa tgaatatttt aaattttaaa tatatcgaaa atcctaaata 515641 tacggaataa caaaaatgga atgttccaat gatgacaaaa aaacttgaaa agcaacaaag 515701 atgtgtcgtt aggaggtaga attcatggta atgacaaaaa aagatacaaa tatatcaaca 515761 cagcagcctc tttggttaca aggttatatt gattcaccag aaaaacaaaa ccaactttat 515821 aaaaaaacat taaaaatctt gattttttca caaatatttg ggggagcagg acttggagct 515881 gggataacag ttggggcgct tcttgcacaa gatatgatag gatcggaaaa tgtagcagga 515941 attccaactg ccctctttac ttttggatct gccgtagctg ccctgcttat aggagcatcc 516001 tcacaacgtt ttggtcgcag agctggactt gcaggtggtt tccttatagg cggattaggt 516061 gctataggtg tgataatcgc ggctttaatt aacagcgttg ccctattatt tgtttctctt 516121 cttatttatg gagcaggtat ggcttctaat cttcaagttc ggtatgctgg gacagacctt 516181 gcaaatgaga aacaacgggc aactgctgca agtatggcct tagtttctac tactttagga 516241 gctgtagtag gtcctaactt agttaataca atgggggaat ttgcagattc aattggtgtt 516301 cccaatttag ctggtccgtt tattatgtca ggagcagctt ttataattgc tggaattatt 516361 ctcttaattt ttcttcgtcc agatccgctg tttgtatcaa cagctattgc gaatgctgag 516421 aaaaaagacg ataaagtaca aataggagga agtctaaaaa atcctgctat agacaaaaaa 516481 ggaataatgg taggagctgt cattatgatt ttagctcaac taatcatgac agctattatg 516541 acaatgacac cggttcacat gggtcatcac ggtcatggtt taagcgaagt gggattagtt 516601 ataggactcc atattgcagc gatgtatctt ccttcaccat tgactggttt attagtagat 516661 aagtttggtc gcacaactat ggctattgct tcaggtgcca cacttcttgc cgctgggttg 516721 gtggcagcta ttgcaccggc agactcatta tcattgctaa tcctagcact agtattacta 516781 ggggtaggtt ggaactttgg tttactaacg ggaactgccc ttattataga ttcaacacat 516841 ccatctctac gtgcaaaaac acagggaaca ttcgatgttt tattagcact atcaggagca 516901 gcaggtggag ccttgtcagg aatggttgtt gcacattcta gttatacaat actatcaatt 516961 tctggagccg ttttatcatt gttactcatt ccagtagtta tttggtattt tagaaggatt 517021 caggaaaaag cataagctta tataactgtc tttgaagaac ctaagtagac attactttac 517081 cggaacctcc tttttctatt tattatagta aggagttgac atggcattag tggcatgtgt 517141 ataactacac aattatttgg gattcagaga gcatgtaatg aacggaagag ataattattt 517201 atcactttta ttattgtacg gtgttcttgt ggcattaagt tcagtcaatt ttggtctaac 517261 tgttttcttt ttgttttcat cacctctcca tattattaac aaacacgaaa aggattttaa 517321 tgaaaataaa atgattagcg tatgtatctc taattttcaa aatgaatgaa tagtcctttt 517381 taagatttac acacttattc tccaaggaaa aatgactcaa tttttcgatt ttttatgtaa 517441 atcaaaaaag aatcatgtta gagtaggtgt gctgaaaata attcaaaaaa ttattttgcg 517501 atatgattaa agtaatattg ccagagagtt tcaattggac aaaattgtaa gtgtttaata 517561 cactggggct gcaatcaaat atgcacctgg aatcaattgc taaacggggg agtttatatg 517621 aacaacaaga aaaatatctt tgatattgtt atgtacatta ttttcggtgt gttaagtctt 517681 tttctagttg caaaaactga ttatggcact ggagttttag tgtttgttgc aattttatac 517741 ctcgctgtta ttgcttataa aattaagcaa gtatttagta attcagattc ttaaggtgta 517801 acacaaggag gatttcaatt gagaaagaaa agagttatta cttgtgttat ggctgcatca 517861 ttgactttag gctcactttt acctgcaggt tacgcttctg caaaggagga ctctaagaca 517921 accccttctt acgaagaact agctctacat tacaaaatga aaagtgaaaa gatttcatcg 517981 aacgggaaat tagttgaaat tgagtatgtg agtggaaatg aaactcacaa agttcagatg 518041 aacggaaata atcatactgt aaaagtcgat ggcatagaac aaaaaggttt aaactttgag 518101 tatgatgaaa atgttgctaa aagaacaaat tatgaaaaca ataatttgaa atcaaatgaa 518161 ttcacaacac aggctgcaaa acctaaaaag ggataccatt atgtggggac tttatctggg 518221 catacaaaag cagctaaaaa tgcgttatca gttacaatgt cattagtcgg tattgtccct 518281 ggcttgggat gggggagtaa ggctgccact attttattct cttattgggc aaaagaacaa 518341 atccctgatg cgtattataa atatgattta tacgaaaaag gagcaatgac tgatagttgg 518401 tatcagtatg ctacagttca attttttgaa gataaagctc ataaaaagaa aatgggcaaa 518461 ccttggacaa gtactcctgc aaaagtagat ttacctaata gctaatttta aaatcacttt 518521 gtctttataa aggacaaagt gattttttgt tatacagaag taaaatccct cgtctgagga 518581 atcttggaaa aaacttggtt caattttgat ataacatgtt tttttcttgc taatttagtt 518641 tttctatgta tcgctacaca ttctaaataa taagatatta gccggacggt tgatgccaag 518701 ctcaaaagtt tatatggaag tcaaagcata aaaaagggtg ttacaacgtg tagtcttctt 518761 tttattttgc caacgtaaca agtgtgaaag taatgatttg taggatcagt taagaaaggt 518821 ttaagattag atattgaaaa attttatata ttttcaataa aatactggta ctataataaa 518881 tgtatacaga ttgtatggag atgtaattaa ttaaaaagga gttttttaat tgcgttggag 518941 taaatggttc aatgtttttt gtatagtagc attgggatca atatatggtt ataaattatt 519001 tactaaccaa gaagtcagta ctactcgttt aataatagct tctgtaattg tgttgtggaa 519061 tattgttgga ctttttagca aagaatcagt aaaacaagca cagcaagcaa attaaaagtc 519121 ataaagttgg gaaagaagga tgttacttat gtagtatcct tctttattat tccttgaaaa 519181 atgaaacaaa ttggagatta cagcttatat aatcaattga agtcgttgat tattttcatg 519241 aacaggagat ttaatgcttt ctgatgaaat attatcgtat gaatgttgca agaggaaacg 519301 ttactcaaag attacaggga tgtgatgaac actcctcttt atcgcactca cctgacccca 519361 aattgttggg gaagggcagg tacggaagat agagtatttt ttcttcgtaa caaatcgaaa 519421 aggttggata ataaaaaact tataatctaa ggcggtatat agttgtgaaa aaggcgttat 519481 ttcttatatt agaccagtat gcagattggg aaggtgttta cttagcatct gcattaaatc 519541 aaagagaaga ttggtcggtt cacactgttt ctttagaccc tattgtaagc tcaataggtg 519601 gttttaaaac atctgtcgat tacataatag ggttagaacc tgcaaatttt aatttgctag 519661 ttatgattgg cggggattcc tggagtaatg acaataaaaa actattacat tttgtaaaaa 519721 ctgcatttca aaaaaacatt ccaatagcag cgatatgcgg tgcagtggat tttttggcga 519781 agaatggttt gctgaataat catagccata caggtaattt tgtttactta tggaaagatt 519841 acaaacaata taaaccgatt agcagttttg tagagaaaca agcagtaaga gataaaaatt 519901 tggttactgc taatggaact gcccctattg aatttactaa tttaatttta gagatgattg 519961 attttgatac tcctgagaac atagagaaaa tgatgtatat gaatcgttat ggtttttatc 520021 atttttgtga taaatatgga aatccatttg ttgattaatt tgctggaaat gattttcccg 520081 aatagggggc tttgcgattg agttgaattt cctaataaag caaagaaaga tgatttgagg 520141 tcaagtttaa caaataatgc catcaatatt aatttgcagt tatttccgat tcctgatata 520201 ataaagaaga attatttttg ttcggtgtaa aggatagtat gaagattgac ttttcgtctt 520261 gatgatactt tgggcaagga tagtatatac tgtgtggtta cacactagga ggcaacaaaa 520321 atggaacaag gtacagttaa atggtttaat gcagaaaaag gttttggctt tatcgaacgc 520381 gaaaatggag acgatgtatt cgtacacttt tctgcaatcc aaagtgacgg attcaaatct 520441 ttagacgaag gtcaaaaagt atcgtttgac gttgagcaag gtgctcgtgg agctcaagct 520501 gctaacgttc aaaaagctta atcttcaatc gtttatacaa acaggctctt tatatagggc 520561 ctgttttttt atgtctatat catactcaat aaaaaaccct actcaacgtt cgagtaggga 520621 gatgctacaa ggtaatagaa aaagatttaa aacttcaaag gtttgtttac agtataacat 520681 actggattga caatatgcgg aatgtatata aattatttaa tgttttgttc aaatatagat 520741 aactgactct ttttttcact aacctgttcg ttcatttaag taagattaga tgaattataa 520801 aaatggtttc atctaaatgt tatcaactcg catatctctt ttatgagaag aagataaaca 520861 attattattc aatgttgcag tggatataag aaattcttaa aaataatgag gagatcgatt 520921 gtttttttct cctggaaata atcacttaga gatacctaaa acaatgaaag ccctacctct 520981 cttccatcct tacggctcct tgtccgtgcc agtgtgaatc aggatactaa aaaaagtgac 521041 tattttattg agttttttgg taaaacttca atcttcgcag aagaaatgta aataataaaa 521101 atggattaga atgtaggaat aacaaaagag gtcgttaatg ttctaaacat aagttggaga 521161 agatttgctt ttcatcataa tattccgaaa tatcttttgg gatgtatcta accaaaactt 521221 tttatttgtt tttcagtgat tcctttaatt acttccagtt cactaatcaa aaattcatat 521281 gcattatcca gcattttttt ttcgcttgca ttaagtgctt tttctttctt catacgcatt 521341 aaatcacgta caacttcagc accttcttgt atttcacctg tttttatttt gtccgtgttt 521401 attttgtacc tttgcttcca tggcagtaac ctatcggatt ctccatgctg aaaaatgtgc 521461 ataatgtgtt ttaatgcaag tatatcggta actggtcgta tattcgaact caatatttta 521521 ctcgttggaa tcataactgt catattactg attgacattc ttatgacata atactgttgt 521581 ttttcctcta agaattcttt ttcttctatg gcttcaatta tacctgctcc gtgcattgga 521641 taaacaatgt tatcgccaat ttgaaacata tcatccacct ccatatatgg tatccttctt 521701 aagattacca tatatggagg tgtaatatca aaattttaat aataacatga tcgaattttt 521761 gatgtcaata acttttttga aaaaacagat caagcaaaaa caatagggaa cgtgtcggat 521821 ttccaatcag gaaaaggtca attgatccgt gtgagcagtt tttcattggc tcaatgacat 521881 tacagaaatg atttgagtag ataagaaaga acgatattcg tgaaatgtca gctaaaaata 521941 tttaaagcac atgattaagt tctaatttct ttaccgattt gatatggata acggccgact 522001 tacttaatga tgcattttca cttatcttgc aagcagaaaa aggtttgttg ataaacattt 522061 agccaccaaa ttggcattat tatcagggaa attgacaacc ttcaaatggg tattgaggcg 522121 agaagaaaaa taaagaaagg agagattata aatgaagacc agaacataaa gaagtaaagg 522181 ggaaagaaca aggttaattg aaaagcaaac tatataaaat agtttgcttt tttttgttat 522241 gacttcactt ctttttcttt ctctttaatg actaataaaa caccgctcag aattaaaaac 522301 gaacctatcc aaaatgtccc gcctatttgt tctccaagca gaatccatcc gagtaaggtt 522361 ccaaccagag gctgaaaaaa gaaaaagagg cctccacttg aggcatttaa taattgtaag 522421 ccgtggttcc acaataaaaa tgcacaagct gttgaaacaa ttcccaaata caaaaggcca 522481 cctagaattt tagggtcaag cagtagtggc gtaaaaatcg tgctagggga gtaccattaa 522541 cagggactcc atttattaat agaataaact ttatgaattc atttttttgt atgataatgg 522601 cgtcatattc atcgcttgtt gaaatttact tatgaaataa ctggtactgt taaatccaac 522661 ttgataagac acttctgtca cattggattc agggtgttgc agtaataata agcttttttg 522721 aattctataa tccattacat aacgtaatgg cgtcttattc agcattcgtt taaaataacg 522781 gcagcattca gaacggctca gttggccagc ttttgcaatg tcctctaatg tgattttttc 522841 aacataatgg agatggatcc agtttaacat ttgtttcatt cgatgacttt ttatcatttc 522901 agattgatcg tactctaatt gaaaaccatt aacgaccagg tttttccaca ttaacgttaa 522961 ttgcatcgta atgtcaatct catagagcga tgtcttttgt tgaatcaatt gatttatttt 523021 tttaacagca tctagaatat tttttgccca ctgttgattt ccagccaaaa ataaataggg 523081 caaattggtt gaaaacatat agggctgaac atagcttgaa tacagttcct gagataaaac 523141 gaaatggggt gacacattca agcaaatata cgtacaatcc gagccttcct tttcttcggc 523201 catgtgcagg tagccgctat tgataaataa tccatcccct tcgtgaacct ctattttttc 523261 ttcatttatt tgaaagagag ctatcccttt tagtatcaaa acaaattgga tttcatcatg 523321 ccaatgaagc ggaatatagc catttatatt ttgattgatc gttgtcttgt agcaggcaac 523381 tggcaattct accgttcggt gctctgttaa ttcttttaaa ttttgatcga tcacaaaatt 523441 cttcattctg acttcacacc tcaatatatt tatatttttt cattcaattt gagtattttt 523501 tatcatgttt tgcatttatt ataacactat tattatattt attagtgagg agtcatgtat 523561 gaatacttcc aatagaagaa tgggattgtt ctatgttatc acaggggcga catgttgggg 523621 gattggaggc acagtagcca aaaaactttt tcaagaatat caaattgatg tcaattggct 523681 tgtaacgaca cgcttgctta cggctggaat gttactttta atgctgcaac tgttcagaaa 523741 ggatcgttcc caggttattg aggtgtggaa acacaaagcg tcggctggcc agcttctaat 523801 ttttggccta ttgggaatgc tagctgtgca gtacacatat atggcatcca ttcaacatgg 523861 gaatgctgcc gttgctacgt tattgcaata tttatcccca gtaatcgtca ttatctacac 523921 gctgttgcga aaacaaacgg ttcttaccaa acaagatatc ataactgttg tacttgcttt 523981 agtgggttgc ttttttttgt taacaaatgg ttcaatgtct caactttcag tgccggcagc 524041 tgcagtagta tggggagttt tatcaggatt cgcggcagct ttttatactt tgtatgccgt 524101 tggtttatta aataaatttg attctcttgt cgttgtaggt tgggctatga ttattggcgg 524161 ttttgcattg ggttttatcc atccgccatg gcaactggat tttcaacgat taactgctga 524221 ggcgtatgca tatatcttat tcgtgatatt atttggaaca atgattgcgt tctggttctt 524281 cataaaaagc ttggaaagcc tctctccaaa agaaacaagc ctactaggca gtctagagcc 524341 tctatcagct gttgtaacaa ctgtcgtttg gttaaaagcg ccatttggtt cttttcaatg 524401 gattggtgct atttgtatta tagggataac tttaatattg gctttacata aagagccttc 524461 tatggagagt gaaaaatcga tattaaagat taggaatcat gcaaatcggg atatataggg 524521 gctttttttg cttacatgac cggtccggca atgaaaaaca ctggtggagt ttgagccctc 524581 tcggcagtat caaaaatacc aagggttttg acgccctagg tattttttct tcaagaacct 524641 tcaatttttc ttctctgatt gaaaaacgta ttactttttt gtgattggta tccaaatttc 524701 acttttaaaa gatggtgatg ttacatcctt atgctcgttc cacaatattt ctggaccttc 524761 tatttgttcg taatttgacg atggaaacca ttcggaataa atgcgtcccc atacttcttg 524821 cagtgtatcc ggaaatggcc cgattgattc gaatacagcc catgttgagg caggaacttc 524881 aagccgtgag aagttatctg gacaccgttt cgttgtggct gcgccaatat agtgatcgag 524941 ctctccgttt tcctctgtcc gaccttcaga aaaattcgtg gatgcactaa tgaggcctga 525001 tggtgctaca ttagatagct cttttagttt atttattgct ttttcatcta aactttccca 525061 catagatgca atttccggat taattccttt gaaaataata ggaactcttt ttttaatgcc 525121 aacgatgcga aatgcctctt tttcttcaat acggtagttc atttcatttc ctcctttaat 525181 tgttagctgg aaggtcattc gtggataagc tttaagggaa tggccattaa atctggcttt 525241 tgatgggttt atgccatgta aattttggaa tgcccgtgca aaagaatctg gtgagttata 525301 accgtacttt attgcaatat caatcacttt tacattgctg tctttcagtt caaaagctgc 525361 aagagtaaga cgtctgcgac gaatatattc cgataatgaa atacctgcaa ggaaggaaaa 525421 catcctttta aaatgatatt cagagcagaa agcaagcttt gctgcctctt gaaaatcaat 525481 atcattagtg aggttttctt caatatactt taacgcccta ttcatacttt taagcaaatc 525541 catttatttg gcctccttta accaaagaat aacaggagtg aaatgtattt atccgacatt 525601 ctgtgcacag ttttgcagga tgacttatat gaaataaagt aagtgattca cttgtatttg 525661 tacaggtttt attgaagcat gctgttcata aaaaggcatc aataaaagaa agttataatt 525721 gtcttataaa cggcacattc atataattga gtgaaaaagg atgcgtatca tgcctatcaa 525781 ttcttttgaa aattatccga tgagctggaa gccatcgatt gataaagctg aaaagcctat 525841 ttataaagca cttgcagggc aattggaaca ggatatttta aacggagttt tattacctgg 525901 aacaaaactt cctccacagc gagaattggc cgattatcta gatttaaatg tgagtacgat 525961 ttcaaaagca tttaaagtgt gtgagttaaa agggctgctg agtgcgactg tagggagcgg 526021 cacatttgta tcgtatgatg cgttgtcgaa tgcgtattta cttgaggata ctaagccgac 526081 acatttaatt gaaatgggag caatacttcc agatcacgct tcatatgagc ccttgttata 526141 ccaactgaaa aacatggttc atgaggagga ttatgaaaaa tggtttagct atggccgggc 526201 aggtgaaagc ctttggcaaa aagatgcagc tgtaaagctc atccaaagag gcggatttga 526261 aacatccgtt gatcacattt tatttgcaaa tggagggcaa aatgcgattg cagcgacatt 526321 ggcgagtctt tgtaagcctg gagatcgcat cggagttgac catcatacgt accctggatt 526381 aaaaactgtt gcatcattgc ttagtgtgca aatcgtaccg ataaaatcag aaaacgatga 526441 aatgagtccg gagtcacttg aatatgcgtg taaaaacgaa aatattaaag gtttgtattt 526501 aatcccggat tatcataatc cgacgacttc ctttatgtct gttgagaatc gaagaatggt 526561 tgcagacatt gtaaagaaat ataatctgtt tgttattgag gatgcatcgt accatcttct 526621 caacaaaaat ccgcttccgg cactcgcctc attcgcaccg caacaggtta ttcatattgc 526681 aagtttatca aaatcgttag cgccaggcct gcgtttggct tatgtagcag tgccgagaca 526741 atataaggag ccaatatcaa aggcgcttta taatttaaat ataactgttt ccccgctatt 526801 agctgaactt actgctcgca cgattgtatc aaatcaattt gaagtcttaa ttgagagtca 526861 tcgtgaacaa accattcgca gaaatcaact cgtaaaccga tatgttgcgg gatatacatg 526921 tttaggtgtt gaaacaggca tttttcgttg gttgttgtta ccgggtaaaa tgtctggtgc 526981 cgaatttgaa gaattggctg ctcgacttgg cgtgcaagtg tatgcggctg aacgctttgt 527041 agtgggaaat agttgtcctg aaagggctgt aagggtttct gtctgtgcac caaaaacact 527101 tgaagagctt gaacaaggat taatgatcct gagacgtttg ctagacgatc ttacctaata 527161 ttgtttgcca tacaattatg acattgtatg gcttttttgt gcgtgttatg atgatccaca 527221 tctagaggga ggtttataca aaattggctt ttagaaagga aggtcagatg atgttagaca 527281 aggacagcgt aaaagcaata gatgttcaaa ctgcttcatt acagagctac atcagttcac 527341 cagaaaaaca aaaatcgtta tacaagcgta cactattcgt tgtgagtatc tcacaaattt 527401 ttggcggtgc ggggctggcg gcaggagtga ctgtcggtgc gcttattgca cagcaaatgc 527461 ttggcactga tgcgtttgct ggtttgcctt ctgctttatt tactttaggg tcagcaggat 527521 ctgcattaat tgttggaaga ctttctcaac gttatggccg tcgaacaggt ctttcagctg 527581 gctttatgat tggcggactt ggagcaatag gcgttattat ggcagcaatc ataaatagta 527641 ttttcttgtt atttatttcg ttgcttattt acggtgcagg tacagccact aatttacagg 527701 cccgttatgc aggtacagac ttagcaaatc ataagcagcg agcgactgct gttagtataa 527761 ccatggtttt tactacattt ggcgcagtgg caggtccaag cttagtgaat gtgatggggg 527821 atttcgctct ttctattggt gttccatcac ttgctggccc tttcatttta gccgcagcag 527881 catatatgtt agcaggtgtg gtccttttca ttatgcttcg tccagatcca ttagttatag 527941 caagaacaat agaagcggca aatgaagagc ctggtgataa aggacatttg gcggcaactg 528001 agcatacaga aaacaaaaaa gggataatcg ttggggcaac ggttatggtt cttacccaaa 528061 tagtaatggt agctattatg acaatgacac cggttcatat gagacatcat gggcatgact 528121 tgggtgcagt cggtcttgtt attggttttc atataggtgc tatgtatctc ccttcacttg 528181 ttacaggtgt tcttgtagat aggttgggac gtaccgcaat ggctatttcc tctggaacaa 528241 cgttgctttt ggcaggtgta atagcagcat ttgctccggg agaatctatg attcttctcg 528301 tcattgctct ttctttactg ggattagggt ggaattttgg tttgataagc gggactgccc 528361 ttattgtaga ttcaactgat actgccacac gagctaaaac gcaggggaca gtggatgttc 528421 tgattgcgtt gtcaggagct gctggcggag cattatctgg aatgattgtg gcaggttcaa 528481 gttacctcgc attatcactt attggaggga ttttgtcctt attactcatt ccggtggtgg 528541 tatggtctag gggccgctaa agggtaggat tgtttaattt acattaattt gttatattgt 528601 tagataaagt atattgcagc atctaatatt ctaacgaact atagttgctc cattaaatct 528661 attataaaga tttgaccagg attccttata gctgtgtcac tcactgcata ttctttaatt 528721 gaatcacata aaatggttat cggatttgaa aaaggcagga ttactcgctt taggtaaagg 528781 agtcataacg ttgttaaaaa ggttttctct tgttattgtt acactaatga tgtctatcgt 528841 tgttgtttta gcggctgcta aagagtcgcc tggagatcat gtcatctcat ttgatgaacc 528901 tattatcttg atgatctcaa ttggaatcgt tgtattttta ttgatccctc cattagtcat 528961 gtcctttttt ggcaatttgg ttgtaagaat aatatctggt gtataccaat gttttatcgt 529021 tttcactttt ctggggctca ttccaattgg atttcttatt cccaatggct ttttgacaat 529081 tctagtttct attgcaggaa ctttagtcag tatagctagt gttgccgtaa ccttatgcat 529141 tggcaagaat aaaaaagata tataatcatc gaattgttat tttttcagat tgtcagtgaa 529201 ataattatac aaaaagagaa ggcttgtggg ccttcttttt ttgttgttgc atcatcccca 529261 ctttgagctt aatctattga ataataagag aaggaaccta tagaagaata aaataaatac 529321 cgagatgtca aaaataaaac tggacttcat tattgtgaat tcacgtaaat gtaaaaagat 529381 tggaaagagg ggaattcctt catgacaaat agcagaacaa atccgaaggt tgatgaattt 529441 ttaagtaaag cgaaaaagtg gaaggaagaa tttgagaagt tgagaaccat cattcttgac 529501 tgtgagctga ctgaagattt taagtggatg catccttgtt acacatatca taataaaaat 529561 attgttttaa tacatgggtt taaagaatat tgcgcgcttc tgttccacaa aggcgtctta 529621 ttacaggata cagatggaat tctcattcaa caaacggaga atgtacaggc ggcgcgccag 529681 attcggttta caaatgttca ggaaataaat gagctagaaa acattttgaa agcctatatt 529741 cacgaagcca ttgaagttga aaaagccggt ttgaaagtgg atgttaacaa aaatattgaa 529801 ttgaacattc ctgaagaact tcaaaataaa ttcgatgaaa tccctgcatt gaaaattgct 529861 tttgaagctt tgaccccggg acggcaaaga gcgtacactc tttatttttc tcaagccaaa 529921 caatccaaaa cccgagaatc gagagtcgaa aaatatgtgc aaaaaattct cgatggaaag 529981 ggattaaagg attaggcacg ccaaggttca ggctaaagga atagcatcat agcgtaataa 530041 gatcatttct atagaagaaa aacaagcata gtaagatgct tgttttttct taggacaaca 530101 ttcacttact gctgaaatgc ttctaacatt gtatgccact agacagcgtt ataaaatatt 530161 aatgcaacac ctagaaatct atccaatgaa atagctcaat ggtatggctc attacattta 530221 gaatgcctag gagaactaat agaaccggaa gatttttagc aagttactac actccaaact 530281 ttgtttttgt attaatatac cttattaacc attgttttta gtcaggtgca gacaaacgaa 530341 tactgattaa tgaatcatca tgatatcaat gagccgcttg attttttcat cgtcgcctgt 530401 atcaacgtac actgtttttc tgttttttat gatactctca gtcacttccc gcatgacgcc 530461 tttttctata tcatcagcgg aatcccagcg taaaggcaca ttatatacat gaattgtgcc 530521 atccccattg ccatgataag tgactgatcc atccactaaa cgagaacctg ccaactgggt 530581 cacattttct ggatagctgg cacttgtatc atcattagga ttaattggct cgccagccgc 530641 aatatgtcga acatttaatt catctatctc ttgattaggt ccaagttgaa gccaaactct 530701 ggcatattca attttttccg aagagtatgc tgccaataca ttgtcttctt tgcttttctc 530761 ttctgctgaa gaggtatcat ttgcagcttt tgttgcggat tcttctgatt ctgttattgg 530821 ctccgcttca tccttgcgta ttttggtgct ctcttcaggc tcagtgtgtt tttcgtcagt 530881 ttgcacagca gaagcttgat ttgaaggttg ttgtgcttct ccatccttac tgtccgtaca 530941 tccagcaagc aaaatcataa gcagcagggc agtattgcaa taacatatct ttctgcgttt 531001 cttcattttt tcattcctct ctattaattc aggtcagctt catatataag tttatgtatc 531061 taaatattac catggaatag ataggatgat attgaaaact gtttaagaag aggaaacgat 531121 cttgaatagc atcgcgaaaa cctaagaatc ttaagaagtt ttgccccttt ttcttcaggt 531181 attgaatgta aagtgggata taaatgcaaa caaaaacgaa atgccttatc cacctcgtgt 531241 catggcagaa aaagtggggg atttattaga gcggatttga taatggcggc aggtaaatgg 531301 gtgttgactt atatgtctaa gcgggagact caagtctgct cgatcgcata caaaatacca 531361 agggccagca acccttggta tttttatacc ttcatgcatt tttgaagttt atgcttaaag 531421 gtctgcctta ctttgcaaat cgccgagctg ctgcaacgca catgataacg gcgatattca 531481 ctgctacgag tgcccagccc actttctcgt gcagaatcac tgaggcaagc agcagtccaa 531541 aaaaaggctg gagaagctgg agctgcccaa ccgctgcaat tcccccttgg gcaagacctc 531601 gataccagaa cacgaagcca atcagcatgc tgaataagga tacatatgca agactgagca 531661 gtgcgggaac gccgatcgcc gaccatgagt ccggcgtaaa aaagaacgac aatggcagca 531721 taagaggaag cgacagaacg agtgcccatg agatcacctg ccaattcccc agacgccgtg 531781 aaagtttggc cccttctgca taaccaagac cgcatacgac aatagaagcc agcatgtacg 531841 cgtcgccaag cggggatgaa cctcccccct gaatgagggc gaaacctgct actaacaagc 531901 tgccggcagc tgagaaaatc cagaagacgg ggcgagggcg ttcacccccg cgcagtacgc 531961 cgaagactgc cgttgcgagt ggaagaagtc caatgaagac aatggcgtgt gcggatgtga 532021 catgctgaag cgctaaagct gtcagcaacg ggaaaccaat cactacgccg aacgctacca 532081 ctaacaatga aatgagatct cttttggcag gatgctgctg ccggaagatg agaaggagac 532141 ctcccgccag tacaccagct atcgcagcac ggcaaactgt gagaaataac ggatcgaagt 532201 ctgacacagc caaacgggtc gcaggcagcg agccgctgaa aatgagtacg cctataaaac 532261 catttatcca gccatttgtt gttttgttca ttataatcac tccacatatc tttcttgttc 532321 attgtctgta ttttcttaac aaaaccagca gctaaggatt acaatgacta taaactggaa 532381 ttggcctttt ataaacagcc agttttcata aaaaaatgca taccagttag gagaacaacg 532441 cgcaaatgga tatcacgcct tttttgaata gaactctgga tattccgctt tatcagcagc 532501 tttatcggta ttttaaagaa aatatgcatc ggggccgtat tcaaaaagga atgaagcttc 532561 cttcaaaaag actcctggcg aatcagcttt ccatcagcca aacgactgta gaacgtgcct 532621 atgaacagct cgctgctgaa ggttatattg tgagcaagcc aagaagcggg tggtttgctg 532681 attatcatga ttctgatttt gcttatgata gaatgccaag cacaacaccc attcaacaag 532741 aagcagaaga aaataaacaa tggattgatt ttcattatgg gaatgtagat tcttcttact 532801 tccctttttc cgcatggcga aaaagcatgg tcaatagctt agaccaatat ggacacgagc 532861 tttatcggcc gggacatgtt ttaggagagt ttgagctgag aacactcatt gcagagtacc 532921 tgtatcaatc tcggggggtt cattgcggcc ctgaacaagt gattataggt gccgggaacc 532981 ctattctgct gcaaatcttg tgccaagttt ttgagccgaa tatttctata gggtatgagg 533041 atcctggtta tccaagagca cgcaagattt ttgaagccaa ccgcatgaat attgttccta 533101 taccagtcga tgatgaggga atctgtatac agaagatcaa agaacagcag ccaaaccttg 533161 tatatgtcac accttcccat caatttacgc tgggaaccat aatgacaata aacagaagaa 533221 ttcagctgct caaatgggcg gccgaaaatc aatcctttat catagaggat gattatgacg 533281 gggaatttag gtacacagga cagccggttc cttctctgca agggcttgat cagcataacc 533341 gtgtcattta tatgggcact ttttctaagt ctcttttgcc ctcgctgcgt atcagctata 533401 tgattcttcc ttcgcctctt ttaaaaaagg gtcatgaaat cacgtcctta tataagcaga 533461 cagtgtcctg ccacagtcag ctaaccctag ctgaatttat aaaaaatgga gagtggcaaa 533521 aacacatcaa cagaatgaga aaactttacc gcaaaaaaag agccattgta ttagaggcag 533581 tgcaaaggga attaggagag catgtcagaa tccgcggaga aaactctggg cttcgtatct 533641 tacttgacgt ttatttgcca tttggtgaaa aagagttaat tgagaaggcg aaaaaacatg 533701 gagtaaaaat ttatcctgtt tctctttctt atcaacatca tcctcctaca aaaacggtct 533761 cgctcgggtt tgcaggggtt tctgaatccg acataagaga aggcataaaa aaactgaagg 533821 ctgcctggaa gatatgaggg agctttcagt ttagcaaaac ggccaagtga cgactaagtg 533881 ttgagagctg ttcaatattt tttaagtata tgatgagtgc ctgcagtcca ggccacgata 533941 cgtctgttta gcgaaaaaca gaatttttta tttgctcctc acagtgctaa aataaacaaa 534001 atagacaatt gaaaaaatag aggtgtaaga atgaagttag atgagtttac aattggccag 534061 gtcttcaaaa cgaaatcatt aaaagtatca aaagatgata ttatgcggtt tgcgggtgaa 534121 tttgaccctc agtatatgca tgtagatgaa gaaaaagcga gtaaaggcag atttaatgga 534181 attatcgctt ccggcataca aacactggcc atatctttta aactttggat tgaagaaggt 534241 ttctatggag acgatattat agccggaaca gagatgaatc atatgacatt cataaaaccc 534301 gtatatccgg atgatgaatt gtttacaatt gttgaggttc ttgataagca gccaaagaga 534361 aatgaattgg gaatactcac agtattgcta tctacttata atcaaaaaga agtaaaagtg 534421 tttgaaggtg agttatctgt attgatcaaa cgataactca gaaagcccgc ttttcgcggg 534481 ctcgattgaa gcagatgggt gaaagatgtt agcgggtttc ctttgaaaaa taagaggtta 534541 aaacatcata aacaataggc aaagaagtaa atccctcatc ttctagaaaa tgacctccgt 534601 gctgaacttc atataacgca gcatcaattt gttgtgccag atccttgctg aatgaaaaag 534661 gcacaatttg gtcgtcctta gaagcaatga cagcacggtg cttcgcggac tcgatgattt 534721 tttgatgatc aaacgatccc tgtgtaaatt catctaacat ctgtaaagtg ggcaatgatt 534781 tggcaaagcc ggaaacaagt atgattccgc caagctgttt tcgtaattga agatgttcca 534841 aaaatctcaa aatggcgggg caacctaagc tgtgcgcaac caaatacgta ttttcatgta 534901 aagtgtgctg atataaagag agtgtatcca gccaatcctc aagtcttggc tggagcggat 534961 taggcatgtt taaaatgtct gcttggaccc catctgcgag cagacgtttt ttcagccaag 535021 ggaaccaatg atttgttgag gaggctctgt agccatgaat gatatagact tgttttgtca 535081 ttatttcctc ctaagaaata ttttcattca gtataaaatt cctctcattg ggaaacaagt 535141 acgcactttt ttgtaagtag ctttacatat gaggccctcc ttgtgccatt ccccacttac 535201 acatctcatc tatgagggga tacaaagatc gccctctgtc agataacgaa tactctactt 535261 tcagtggggt gtgagaaacc tcagaccgat gaataaggcc gtcagtttgc aattccttaa 535321 gctgtgcgct taacatttta tgggtgatga agggcatagc ccttttcagc tcgccgtatc 535381 tcatcgtttt ttcacaccct aactcataga gaattctcat tttccatttg ccccctataa 535441 gagataaggt gtattcaaat ggggcttgtt tactgcggca caggctattc attgtaatca 535501 aacctccttt tttaagtatc atatcagaat aaattaggat tttcggtgtt gaagtttgag 535561 ggcgattcac gatctgaagt gaaaggggcc gcttgctcaa caggcggcac ggtacatgaa 535621 tgttctaagt caaagagggt taccttactg ttagttactt tatttaaaaa aacgcatgtt 535681 tttagctgaa aatatctatt atggtatatt taaatataaa gaaatatttg agaaatgagg 535741 aatggtatga atacacccaa aaaacataag aaatttaaag cgaaaatgat tctccaaatc 535801 atcatggtta tcattggagg aatcatagcg gcatatggac tagaaacagt gctcattcca 535861 aacagtgtat ctgatggagg ggtgacgggt cttagcatcg ttggttcaca gctattcaac 535921 ttgccgctgg ggattttgat tgctgtgatc aacattccat ttgtctggtt aggatataag 535981 caaattggga aaagctttgc attattatca attatcggaa tcgtatcgct tgccgcgggg 536041 acaagctttt tccaccacac acccgctatc atagaaggag ataccctgtt aattaccgtt 536101 gtcggcggga ttatccttgg attcggaatg gggctggcgc tgcgtaatgg cggcgcatta 536161 gatggaattg acatgcttgc tgtgctgcta tcccgaaaac tgccattcgg aacgagcgat 536221 ctcattctat tcttaaacct atttgtgttt atttttgttt ccacagtatt tggcttacaa 536281 ggggcattgc tttcagtcat tgcttactac attgcatcca aagtgattca tgttgtggag 536341 gaaggcttaa gcggctctaa aacctttcaa attattacaa cccaacctga attaatggta 536401 gagacaatac gtgatcaatt aggccgaagc gccacatata aagaagctta cgggggtttt 536461 tcccacgaga aatttaaaga aatcacatgt gtcatcaacc gtttagaaga aaccaaacta 536521 aaggaaatta ttaatgatat tgataaaact gcctttgtta ccgtgtatga tgtagctgaa 536581 gtgaagggca gcaattttag aaatcttaat catcactaaa aaatagaatg acctttttaa 536641 ccgtaactga catgccgcgg gtaatttaat caaaaacact tttttgaggc ttgtgggtga 536701 ataaccggtg aaggtctgaa tcacagaaat accaagggcg tcaaaaccct tggtattttt 536761 tctggttatt agattttatc ttcagcttta cgtgctgctt cgagcttatc aatcctgtct 536821 ttatattttt ctccccagtc cttcatgtgc aggataacag gttctaatgt tcttccaaac 536881 tcagttaaag agtattcgac ttttggaggg acctgtttat aaacctcgcg gtgaatcacg 536941 ccatcccgtt ccaattctct taattgtagc gtgagcatac gctgggtaat ttttgggtat 537001 agttttcgaa actcattaaa cctcttttta ccgtcaatga gatgataaag aagaatgcct 537061 ttccacttac ctccgatgat atctaatgtt gtctccaccg gacatccttc aaagtcatca 537121 gaagaataat caatgccgag tttacgattt ctcaagctgt tcactcctaa tagtatactt 537181 tttgatacta tatacattca atgtgcgtac tttttatatt ttaatataca tcatataatg 537241 atgtcacatc taaggaatga aaggaatgga tcatatgaaa acactcgtac tcgttgtaca 537301 tccgaatata gaatcctctc gtatcaataa aaagtggaaa gaagccgttt taagtgaacc 537361 agatgtaact gtccatgatc tttatgaaaa atatcgcgat caaccaattg atgtggaatt 537421 tgaacaacag cagctcctgg cccatgaccg tatcgttttt cagtttccat tatactggta 537481 cagcagccca ccgcttttaa aacagtggtt tgatgaagtg tttacgtttg gctgggctca 537541 tggtcccggc ggaaataaat tgaaggggaa agagtgggta actgccatgt ccatcggttc 537601 acctgaacac tcttatcaag ccggcggata taacttgttt tcgataagcg agctgacaaa 537661 accgttccaa gcatctgccc atttagtagg catgacctat ctgccttcct ttgccgaata 537721 tcgcgccaat acaatcagtg accaagaaat tgccgaaagt gcgaatcggt atgtaaagca 537781 tattacaaat atagaattaa acccgaaggt tcgcctgcaa aggtatttga aacagctgga 537841 gagtgtcgat ttaacataaa gattgatttt tgaaaatcct gtactcacca agcaggattt 537901 tttcttgttc agcagaggga ttttaacata tagcaaaaaa agaagaagcc accaaaaata 537961 agctatttgc ttggtcctga ctgcttattt ttggtgaaat acttatttct ctgtgatgaa 538021 ataaagcaaa gcgatgaccg gaaaagcgat tccaatccat aatgctgtac tccatccgcc 538081 tgaggcatat gcccatcctc caattgatga ccctatcgca ccgcctagaa agaagatcgc 538141 catgaataat ccgtttaatc gactgcgaat ttcaggcgcc aacgaaaaaa tagcacgttg 538201 actgagcaca aggtttgcag atacacccat atctaacaga atagcagcgg ccactagaac 538261 tgttataccg acgggggagc tgctctgaat catgagcggc agtaataaag agacaacgac 538321 aacaccgaga gcgattccag tggcaagcct ggttaagcct cgatcagcca ggcggccgcc 538381 tattggtgca gtgactgcac ccgcaatgcc caccaatgcg tagagtgcta ttgccttctg 538441 agaaaaatga aaatcaggac cggacaataa taaaggaaca gttgtccaga acaagctgaa 538501 agctccaaat acaaacgcat gatagatggc acggcggcgt aagactggag tcgtgcgcag 538561 cagcttccac attgaaccga gtaaggcagt atagtttgta tttgctgttg gttttctggc 538621 aggaagcact tttgataata cgatggccag gataacactt accacggcgg acaaagcgaa 538681 tattgcattc cacccccaga tatcagcgac tagactagat atcggacggg aaagcataat 538741 accgagtaat aagccgctca tgacattgcc aacaacccgg ccgcgtgcag cgtctgatgc 538801 aaggtatgat gcaaatggaa caagcacttg ggctgcgatt gatcccaatc cgacgaaaaa 538861 cgcagctgct aaaaacagtg ttccatgctt cacaaatgct gttagtgtca aagccgctgc 538921 gcttagaagg agcgatacaa caataagttt tttgttttcg ataatatctc ctaaagggac 538981 aaggaatagt aagccggcaa cgtatccgat ttgggtgagt gtgacaatca atccagcacc 539041 gcttggagaa agtccaattg ccttactaat taatccgacc aagggttgtg catagtaaag 539101 attagcaaca atgataccgc atgcagttgc gagaagaagg gttaaactgg gtgaaatcct 539161 ctgacctgct tgtttgtttc cattagccat atgaatgaac tcctttttaa gtggtttttt 539221 gagtgtaatc atgacttctc acaagtgatt ttataaactg aacgttcagt ttcgtcgatt 539281 aataaaaata atatactaaa cgttcagttt tgtaaatgga tttctgtttt ctttttttat 539341 tcaatttaag tatactgaac gtatagttta tattgcggga aggaatgatt tatgtgcaga 539401 gtaaacgagg gcggccgcgt gatgaaggaa cgcataaggc gattctctct gcagcctatg 539461 acctattgct ggaaaaaggc ttcgatgcgg tgacagtcga taaaattgcc gagcgtgcga 539521 aagtgagtaa agcaacgatt tataaatggt ggtctaacaa ggctgccgtt atcatggaca 539581 gctttctttc gaccgcgacg gacaggctgc ctgtgcctga tacagggtcg tcagtacaag 539641 atatagtaac ccacgccacg aatttagcta ggtttttgac aagccgggaa ggaaccgtta 539701 ttaaggaatt aataggtgca gggcagttgg atgaaaaatt ggcagaagaa tatcgcacgc 539761 gatttttcca gcctcgccgc ctccaagcga aaggccttct agaaaaggga attcagaaag 539821 gtgaattgag agagaatctt gatattgaag taagcataga tctcatttac ggaccaattt 539881 tctatcgtct gcttataaca ggggatgagg tgaatgattc ctatgtgcgt gatttggtga 539941 tgaatgcgtt taagggagtt caagctacct ctgctacaga gagtatgtag ctgataagaa 540001 ctgcaaaagc tgcggattat atgacaaatt ggttccatcg tacagtgaaa tataagattt 540061 ttgttgctga gcggaatcat cgagggaaaa gttctcttat cggatgtcga aaaagaagtc 540121 attcaatcgt gaatacataa catcatatta ttacattcct tttcatcgat tggaacaagg 540181 gttctatact tcaatggaat accgcaaagt tggagtattt aaacaacagg ggaaaatcga 540241 tggccattat gtaggtgtca tggcaatgga aaaaatactt gcaatgtaaa caggcctcta 540301 aagagacctg ttttttaata tccagatgat tgtctagttt cagcttgggc tctatgacca 540361 ctcccataac tgaaatagtc taatatttat accagaaggg attgtttata taaataaaag 540421 tttatataat gacgggggcg ctaaggaaac gcggggagcg actcaggttt tcgtttcaaa 540481 gttttgatcc ttaagatata cggagcgcta catatggaaa cgtaaagggg aatgtataat 540541 catttggcgt gtatataacg atttgcttat atattgattt gggaaggagg agctcatatg 540601 acgattgatg ttgcggcgat gactcgttgt ttgaaaacac ttagtgatca aactaggctt 540661 atcatgatga gattatttct tgaacaagaa tattgtgtct gtcaattggt tgatatgttc 540721 gaaatgagcc agcccgccat aagccagcat ttgcggaaat taaaaaacgc aggttttgtg 540781 aatgaggaca gaagaggcca atggcgttat tattcaataa atggttcctg tcctgagttt 540841 gatacattgc aattgatctt acatcaaatt gatcaagagg atgaattgtt aaaccatatc 540901 aaacaaaaga aaactcaagc gtgttgccag taaggaggca ttagattgac atcaatgatt 540961 ttggcagtat tcatcttttt attaactcta gtattggtca tatggcagcc gaaaaattta 541021 tctatagggt ggtcagcctg tggaggcgca gttttagctc taatagcagg tgttgtcaat 541081 tttcatgatg tgttaactgt gacagggatt gtttggaatg cgaccttggc ttttgtggcc 541141 atcatactga tatcgttaat tcttgataat atcggtttct ttgaatgggc agcgcttcat 541201 atggctaagg ctgcaaaagg atacggtgtg cggatgttcg tttatgtatc tctattagga 541261 gctatcgtcg ccgcgttatt tgcaaatgac ggtgcagctc ttatattgac accaatcgta 541321 ttagcgatgg tcagagcatt acattttaat gaaaaattag tttttccttt tatcattgcc 541381 agcggattta ttgcggatac cacttcgctt ccttttgtag taagcaattt ggtcaacatt 541441 gtttcagcgg actattttca tattacgttt attgattatg catccagaat ggttgtcccg 541501 tacctgtttt cgctgctggc gagcatcatt gtactttacc ttttctttag aaaaagcata 541561 ccaaaacgct atgatctgac tgaggttaaa aaacctgttg aagcaattaa agatcaaaac 541621 atgttcagac tgtcatggta tatcttaggg ctgctgttaa ttggatattt tgcaagtgaa 541681 tttttttcta tccctgtatc agtggtagcg ggcagcattg caatcatttt cttaatcgct 541741 gcgcaaaaga gtccggccgt ccatacaaag aaagtggtga aagaggcgcc atgggctatc 541801 gtattctttt caattggcat gtacgttgtt gtgtatggtg tccgaaatgc cggattaacg 541861 gatgtccttt cagatgtgat tcaagccgca gctgatcaag gattgtttgc tgggacaatt 541921 ggaatgggct ttattgcggc gattctttct tccattatga ataacttgcc gactgttatg 541981 attgacgcat tggccattgc cggtacagat acacatggga tgatgagaga agcgcttatt 542041 tatgcaaatg tgatcggttc agatttaggg cctaaaataa caccgattgg ttccttagcg 542101 acattattat ggcttcatgt tctttcgcac aaaggtatga agatttcctg gggcacgtat 542161 tttaaaacag gaattatcct cacgataccc actttattga tcacacttgt cggcctgtat 542221 atttggctgc tgataatcca ttcttgtttc taaaaggaca aggtcactat atcaaggaaa 542281 acaatgcact ggtaactctt gccgcagcca aatggctgaa gggtggggga gaaaatacct 542341 tggggctaag tggaatgtgt acagcgcagg aatcgaagct caaggatgac atcgagtgct 542401 gtcaaagcaa tgaaagaagc agggattgat atttcaaatc aaacatcgga gaaatttgat 542461 gatccggcaa aagcacacgg aacagaagaa gtgtttccaa agggtccgtg atgaaattgg 542521 tgaccgttta aaacagtttg ctgtaactgg ggaataaaga atcgatatat tcagcgtttt 542581 cttgggttat ataatacaat gtgttgttca acaggtgtct gcgagctgag tgcagacacc 542641 tgtttttgtt tttatttgtc tgagattcgt aacagggaag ttatttagct ggtgacagag 542701 gaaaattgat ttgtgaacag aatcatgaag gagacggtgt tttaaaggag ttgtctgttt 542761 tgcaggaatt aacaaaaaaa aaatacagta gcttaaaaac aatgtttgat gacaaatatt 542821 gtcccacatt tgtctattca atattagacc aaaccattcc gggagctgtt tatgcagatg 542881 atcaaacctt tcctaaatcg ttttttatag gaactgaatc aggcatttat tttattgcgg 542941 gagaccaagg gaatcgggat tttcatgatt tcattgcagg atattatgaa gaacaagtga 543001 aatcatcaaa acgatttacc ttgttttctt ccagtgatac atgggatagc gtactgaaac 543061 ccatactgaa agatgactta aaccaaatga gaagagctgc attttcttat caaccaaaat 543121 ctttcaaaaa gactttgcaa ctgccaaagg ggcttgtatt gaaaagaatt gacgaagaca 543181 tcatttcaca tagcacagcg tttaacagcg cgtattatga ggagtattgg aattctgtct 543241 cacagtttgc ttcaaaaggt tttggatttg ccgtattaca tggcaatcac gtagtaagtg 543301 agtgtacctc tatattttta gggcataatc gagcggaaat ggatatctat acacttgaag 543361 aatatagagg actggggtta gcttattgcg tagcaaatag gtttatagcg ttttgtatgg 543421 aaaatgggat tgttcctagc tgggattgtg atatttgcaa caattcgtcc attgcattag 543481 cagctaaact agggtttaag acggtaacgg aatacactat ttactactct ggctaacctt 543541 aatgaaagaa ccttaaaagg agataccaac cgatgttggt atcttttttg ttttagagtt 543601 tttttaccct tttagcagaa aaatgggtga tgaaaatctt attcatttta tttactttta 543661 ggtaggtaaa acataccccg ccaactgtaa ccactccgcc tagcagagag agcagtgtgg 543721 gtatctcgcc gatccagagc caagatatga tcaaggctaa agccggtgta acataaagtg 543781 aaagggttgc ttctgaagca ccgacgaatg aagtgacata tgctagtgcg aagtaaggaa 543841 taaccgtcgg caataatcct aagtaaacga tagacaaagt tgcgcttatt gaagcgttca 543901 tcatctcttc gcctaagcct ggcagaaaca caagcatagg tattgttccg ccccaaatgg 543961 tgaatgtaac gaatggaata aaaccatatt tttttatata gcgggcttga aaaacgaaat 544021 aaatactctc cgaaaatgct gccagcagga tgaccaagat accgctcatt gaatatgtaa 544081 agtctcccgc cccaaatgca atcaataata cacccaataa actgatcata gagccaagcc 544141 atttcgtaaa tccaaaatgc tctttataaa acaggcggga tagcatggct gagaagatcg 544201 gtgccgtagt aacgagtaag cttgcaactc cggcactaac tgttttttca ccgatgttca 544261 gcaaaatgtg atagaatgca aatcctaaaa accctaaaag aaaaatggca ggaatgtctt 544321 tcaagtcggg taggcgcatc tgagtcaaaa cagcaaaaag caataatgcc atagagccga 544381 ttaacaaacg aaataaagca aggtgttctg gcgtgtaccc ttcaagtcct gcgcgaattc 544441 ccggaaaagc agatgcccat aaaccaatca tgagactatg agatatcatt atttgaactg 544501 ttttctttcg cattcctctc actcctcttt acaaaaacca accagttatt taatgtgttt 544561 ctatactaat aaagatttga tgatatggct tcaaccagtt caatagattt tgacccaacc 544621 aatttatttt aaggagaccg attctatgag ctttccagaa gaaaaaaaga tgaaaaagct 544681 ccctaagtac agacaaatcg ttcattttat taaagagaaa ataggaaatg gagagtggcc 544741 gattggaagc aagattccaa gccagcgcac gcttgcaaaa gattttcagg taaatcggag 544801 cacagtgatt acagcgttag aggaattgat ggccgatggg ctaatagaag gcacaatggg 544861 gaaaggcaca gttgttatca acaacacatg gacactgatg gctaagaatt ctgctcccga 544921 ttgggatcaa tatgtcacct ctggcattca gatgccaagc cgaaaaatcg ttcaagagat 544981 aaatcaatca gaatcaaata cagaccttat acagctcagt aaaggtgaac tttcagctga 545041 gatttttcct ttggctgtta tgaaagagat gatggggaag gtatctcaac acatggaggc 545101 attcggatat gaagaaccaa aaggttactt acctttgagg gaggcattaa gcaactattt 545161 aaaaaccatt ggaatcaacg tctcatcttc ttccattctg attgtctcag gagcgttgca 545221 agccttgcag ctgatatcaa tggggctgtt acaaagagga tcaaccgttt atcttgatca 545281 gccctcctac ctttattcat tacacgtatt tcaatcagct ggtatgaagc tgactggact 545341 tcctatggat aatgaaggac ttttgcctga aaatgttcat ttaacaagag gagagcgggg 545401 aagggctatc ttatatacaa atccatgttt tcacaatccg actggtattc ttatgtctaa 545461 aaagcgacgg gaagaaatcc tagcagtaag tgagaataca cagcttccta ttattgaaga 545521 tgacatttat cgtgagttat ggatcgatga aattccgcca tatcctatta aaacaattga 545581 taaaaatgga cacgtactgt acataggaag tttatcgaaa acattaagcc caggtttgag 545641 gattggatgg atcgtcggac cggaaccggt gattgaacgt ttatctgaca ttaaaatgca 545701 aacagattac ggatccagtt cgctatccca gagagtagcg gcagagtggt ttacttccgg 545761 ccactaccag cagcatgtag aaaaggttag gcagcaatta aaggtgagaa gagaattggc 545821 cttgagtgct ttagaaactc atttgaaaga agtggcgaca tggaatatcc caaaaggagg 545881 gttttttgtc tggataaaaa tattgccttc catatcaatg aaattacttt atactaaagc 545941 cttatcaaaa gggattctga tcaatctcgg cagtatctat gctcaggaaa aagggaatta 546001 tattcgctta tcatatgctt atgcatctct tgaagacctt caaaagggga tttatgagtt 546061 gggtttaatg attaaagaat tggcaagcag gtaactttta tatccttaaa tggatgtttc 546121 actaaaaaag agatcaagcc taatgatcgc ttgatctgat aataacaagg gttactagaa 546181 tagaccaaat catggttcgg tcttaaaata atcatgtctc tgaacgaaaa gtctttccga 546241 cttctcttcc taaaccaaag tagtgtctga aattatagat aagcgggctc catttggaag 546301 ggttgatatg gttttcgtcc agaatgatac tttcctcggc atgaaaatgt agtgcctgcg 546361 tctctacaat tgcgaatgac gattcatatt ctggaagccg aatgtgtttc acttcggctt 546421 cgatttggat agggcattct ttaattcgtg ttggtgatac tgtttttgat tgtaaaggcg 546481 ttaaccctgc tgcctcgtat ttttcttttt tatatgtaaa tccgatctgc ttctttaaag 546541 gcggtatact cttttttccg ctataagatg aaattctttc aacgttttcc cataaatccg 546601 ggccaggcaa gtttatgaca cactctttgt gtctttccaa attgtcgatg gcttttcctc 546661 ccagtcctac tccaaggatt atataatgtc caagagccca agaagaagac ataggactaa 546721 tattagtggt tccatcctca ttcaatgtgg ttagaagaaa tgtcgaggta ccataataca 546781 tgatcttggg tttgatttcc ttaaatcgac gagtgtcttg ttttttgatg tccaacgttt 546841 tttcctcctt gtcacgctta catttatatt gtaaaggatt aacatttcaa ctatcatcga 546901 aatatgaatg taaggaggaa aatcatgaat cctaatattg caaaaatctc ttcgttgcta 546961 tcagatccct cgcgttcttc cattcttctc agtctgatgg atggaaggat acaccctgcg 547021 ggagagcttg catatctcgc taacattaaa cctcaaactg caagttttca cctgaataaa 547081 ttgcttgaag caaagctgat tagcgtagag aagcatggga gacatcggta ttacagattg 547141 gctgactcag atgctgcaaa tgtgatcgaa caattgcttc atattgcgcc taaagcaaaa 547201 gtcaaatctt taaaagagtc aaaagagaaa aaggacttgc atttcgcccg gacctgttat 547261 gatcatttgg caggttatgt gggcgtgcaa atggcacatt cactagttga gcaggggatg 547321 ttaaaaaaag ttgatttaaa ctttgaggtg acttcagagg gtgctttatt cttttcgaag 547381 ttaggcatca atgaagagca acaacggaat aagaggagag cctttgcccg ctgctgtttg 547441 gattggagtg aacggcagca tcatattgca ggagcattag gaaacgccct attggtgcgc 547501 atgttagaag aagaatggat cgttcgtatg cctaaaacga gagcgattag gattacacaa 547561 agcgggaaaa tcgcgtttga aaagcaccta aacgtgaaga tttaggattt tgaagcggaa 547621 acatcagatg atgaggcacg atatctagga ggagtaagat ttgttctaat cttactcctt 547681 cttcttattt tgaagcagct cgattcccca ttgcaataga gatgcggttc caactgttta 547741 tttgattaat gatcagaaca aggtcaacat attgttcctc atcataatgt tcccgcaccc 547801 gatgatatag ctcatcagga acccttttag atggaatgag cgtgatgtgt tcagatagtt 547861 cgagagccgc tttctcttca ggtgagtaaa aatcacattc attccaagca tgtaaacagt 547921 aaattcgctg ttcagtttct cccattttgc gggcatcgga cgtatgcata tctatgcaga 547981 aggcacagcc gttcatttga gagactctga ttttgattag ttctctcgtc gttcggttaa 548041 ttgaggattg tttcgtgtat ttctccatat ccatcatgat tttcatacct tcaggtgcaa 548101 tctcatagta ggacactctt tgactcataa agcaagactc ctttccatag aatacctaga 548161 ttgtatcccg gtattgatca ttttaccaat gtgcggtttg aatgacagct gtttcagcgt 548221 cttttggaaa gaagcttctt tgaataaaaa taagggtagc cagcaatgat gagtggagct 548281 gctaatgcaa gcagtatcca tgagcctgat tggctgtctc tagtgactct aatgaatata 548341 taagtaccga tcagaaaata taataaagca cctagaaacc aatacatgtt cattcctctt 548401 tttccttgct ttttggttgc gcatttttgt ctgtcatatg gcttaatcga tcagggttct 548461 gattttttaa taccttttcg gtccggattc cttttctctt taatgataaa attgtgagat 548521 caatcgattt caatgatgat cattccttca atgaatagta agttccttat gattttaaag 548581 gtaaatttga aaagataaaa cgtacataga ggcagaacgt tcatgtacgt ttgggcaatg 548641 atcacttgtt ggaaactcta atgtttccct gcacctgata ttgttgtgtt ccttctcttc 548701 ctataaaatg attggataca tgtatgtttg cacgttgaaa tatgggttcg attttcatga 548761 atctctattc ggtgaaacag gtaaaggaag tggataaggt ttgcttataa ggaatccttt 548821 taaagataaa tattactcac atgataggcg ggcattaaac atgcttgcac tcagagtgcc 548881 gggcctggct tttattctca tgatctatat agcctctatc gtgctgcaat ttgtttctgg 548941 gggctggtcc attttattgc tttatgcgtt taccatatta atcgccattt ttgctttgct 549001 tcattggcac tcatatcgct gggttaagaa aagagtgatt ctgtatttcg cggtacaagg 549061 tttgatcacc tttgcacttg ctaatctcat gactggcttc tttatacttg tgattatcgg 549121 cctttatgca tttttaattg gacaaattat aggaatggca gacagaagaa ggacttttct 549181 cattctttat ctattgctgc tgctggtcat aaattcggcg tatcaccttc ataaaggtga 549241 agttttgcat tttattgtta ttgctgcgcc gatcatgatt gtcatcatca cttatgccgc 549301 aacatttttt gcccaagtcg atgaaaaaat aaaagctcaa ttgactcttg aaaggctgga 549361 gctggctcat cagcaggtag aacagctgac gctgcagaac gaaagacagc ggatggcccg 549421 agacttacac gatacgcttg ctcaaggtct tgtcagttta aatatgcagc tggatgcgat 549481 tcatgttcat ctcgccaaag gcaacacaga gagagcgaag gaaatcatac aacaatcgat 549541 gaaaagagtg aaaagcacaa tagctgatgc acgttcagct attgacgatc tccgcagcaa 549601 atcagaagaa atcggtgttt taaaagaaag aattacctcg ctaatggatc attttataga 549661 gtcgacaggc atggcttgtt tattagatta cagattgcat caggtgctgg atgtgcgtac 549721 agctgaaaac tgttattaca tcattggaga atgcatgacg aatgcggcaa agcatgctga 549781 ggcgaaaaca atctggatat ccatttggga tgatgaaaag ggaaggctcc atttaacagt 549841 taaggataac ggcaagggat ttgatgttga aaaaggaaag aaaaagagag gacattatgg 549901 gcttcttggc atacaagaac gcgtcagggc aataaatggc caattcaata tcaagagtac 549961 aaaattgaaa ggaacacaaa ttgagatcac tgtaccaatt cagggagaga tgcaagatga 550021 ataaggtttt aatcgttgat gaccatcttg tcgtgaggga aggtctgaag cttttaattg 550081 aaacgaatga tcaatacacc attataggag aggcggaaaa tggaaaagta gcagtccgtc 550141 ttgcagatga attagaaccg gatatcattc tgatggattt gtatatgccg gagatgagcg 550201 ggttagaggc cattaaacaa ataaaagaaa aacacgatac ccccatcatt attttgacta 550261 catataatga agatcactta atgatcgaag ggattgaatt aggagcgaaa ggatatctgt 550321 taaaagatac gagttcagaa accctttttc acacaatgga tgcagccatc agaggaaatg 550381 tgctattgca gcctgatatc cttaaacgtc tgcaagaaat ccaatttgag cggatgaaaa 550441 agcagcgcaa tgagacgcag ctgacagaaa aggaagtcat tgttctaaaa gcaattgcta 550501 aaggtcttaa aagcaaagcg attgcctttg atttgggcgt ctctgagcga acagtaaagt 550561 ccagattaac gtccatttac aataaattag gcgcgaattc aagaactgag gcagtaacga 550621 ttgccatgca aaaaggtatt ctgacaatag acaactaaac tgcatatttg aaaattgccc 550681 aaacgtacat gcccgaatgt acgttttttt catttcattg tcaactacaa tgagaaagaa 550741 tgtgatcaag caatgtgttg aaaggagatt atcatgtcaa aaatgttata tacattagga 550801 ggatgggttg ctcgcaatcg cataaaagca atatgtgcgt ggatcgttgt gttagttgct 550861 gcgataggcc ttgcagtgac cttgaaacca agtttttctg aggatatgtc catacctgac 550921 acaccttcgg aaaaagcgat ggatgtgatt caaaaagaat ttcctcatgg tcctgataaa 550981 gggagcatac gggttatttt cggtgctggt gatggggaga aacttactgg gaagccagca 551041 aaaaaagcaa tagaagatac gttcaaagaa atcagtaaag atgattctgt tgactcgatt 551101 gcaagtcctt ttgtgacagg gacaatcgcg aaagatggca cagttgccta tgctgatatc 551161 cagtataaat catcagcaga tgatataaag gattactcta tcaaacactt aaaagacagt 551221 ttgaaaatgg ctgatgatga aggattgcaa actgagctaa gcggagatgt accgggagcg 551281 gagatggaga taggcggtgt ctctgaaatt gtcggcatta tcttggcttt tgtcgtttta 551341 gccattacat tcggttcttt attaatagca ggtttgccga ttttaactgc actgattggt 551401 ttaggtgtaa gtattggact ggttttgatt gggacacaag tatttgatat tgcttctgtc 551461 agtctttcat tagccggaat gattggcctt gctgttggta ttgattatgc tttatttatt 551521 tttacgaaac accgccagtt tttaggcgaa ggcatacaaa agaatgaatc aattgcgaga 551581 gccgtgggaa cagcgggaag tgcagtggtt tttgccggac ttactgttat cgttgcactt 551641 tgcggattaa ctgtcgttaa cattcctttt atgtctgcga tggggctgac agcagggctt 551701 agtgtactga tggctgtttt ggcttccatc acacttgtgc ctgcggtctt atcgattgca 551761 gggaagcgga tgattccgaa atcaaacaag aaaatagaaa aacaaagcac tgaaacaaat 551821 gtctggggac gctttgtcac caaaaatcct atcatgctaa gtgtatgcag cattctgatt 551881 ttgatcgtca ttagtatccc atctatgcat ttggaactgg gcttgcctga tgctgggatg 551941 aaagctaagg ataatccgga tcgccgggca tatgacttgc ttgccgaagg ctttggagaa 552001 ggatttaatg gccaattaac aatcgtagcg gatgccacaa atgctacaga aaataaggcg 552061 gaggctttcg cagatgcagt gaaagaaata aagggcttag accatgtagc aagtgtcact 552121 cctgcaatgc ctaataaaga agggaacttt gccatcatta cggtcgttcc tgaaacaggt 552181 ccaaatgatg tcacaacgaa agatttggta catgatgtac gcagtttatc agataaaaac 552241 ggagtagatt tgcttgttac tggatcaact gcagtgaata ttgacatttc agatcgcctg 552301 aatgatgcga taccggtgtt tgctgtactt attgttggct ttgcgtttgt attgctgacc 552361 atcgttttcc gttcgctgct tgtgccgctt gttgctgttg caggtttcat gttgacgatg 552421 acagccactc ttggaatctg tgtatttgtc ttgcaagacg ggaatctcat cgactttttc 552481 aaaatacctg aaaaagggcc gatactcgcg ttcctgccga ttttatcgat tgggattctg 552541 ttcgggttag ccatggatta tcaagtattc cttgtcagca gaatgcgtga agaatatgta 552601 aaaacaaaca atccagtaca agccattcag gctggattaa aacacagtgg tcctgttgtt 552661 acagcagccg gcttgatcat gatcttcgtt tttgcaggat ttatctttgc aggcgaagct 552721 tctattaaag ccaatgggct ggctctttcc tttggtgtac tctttgatgc ctttattgta 552781 agaatgacac tgattccaag tgtcatgaag ctgatgggga atgcagcctg gtatttgccg 552841 aaatggttag acaagattat tccgaatgtg gatatagaag ggcatcaact gacaaaggaa 552901 atacagccgg aaatagatca tgaacaaaag aaacaaatca gtgtgtaata gaaaaagcag 552961 atcttttatg atctgctctt ttgcttatgg tagtatttag aagatgaagt cggcagttaa 553021 aaggagacgc ttatggcgcc atcactcatt ttcgatatgg atggaacttt gtttcatatt 553081 ggcagaagct gcatcatact agcaggcatc ccaggagaag tgacatgatt ttttgacttt 553141 gcattcacta cttgatgcca aggatcttga gaatccttct tgaaaataaa ggattttaca 553201 actgatcata taagaaacct aaagaaacaa gcacacaaaa ccagctgcgg gttttgtcca 553261 agaaaaatag agtccataag agggactcta ttttttgaag tgcccggcta gaagcatatt 553321 gcaggacttt atgaatgcaa atcactatct tataagccct taccgtgaaa tgcctgtttc 553381 tgcattgaaa aaacgcatta cacgttcatt tacgtaagtg ggttgttcca tcgataaaac 553441 atgtccggca tttttaatga cttccgcctc aatatctgga acgaatgaag aggctcggtg 553501 cagggctgag tggggatcat agatgacttc atgttcacca agtaataata ggataggaac 553561 tcttgctgaa cgtaattcct catcggtaaa aacatacgga aatccgtcgg cattaggatt 553621 tggatttctt gatccatcct gccacattac ccctgcctta aactgcttca caaaaatcgg 553681 gtgcagcaca ttctgatcat tcatcatcca atttaagaat gtttcaactc catttgacgc 553741 tgtaaggcca agagcgtatt tgtagaaatc gtgatgaaat ggcaaaaacg tttctgccgg 553801 actcagtata gctgcgcttt ttactctctc aggcatacgt aaaaggaaat tcatcgtatg 553861 gagaccgcca agcgaaagtc cgatcatgtg ggacttttcg atccccagat tgtcaaacac 553921 atcaagaagc caattggcgt aatccgttct tgtaccgctt acattctcag gaatactctt 553981 gtttttatca cctatgatat caactgcata agttctgtat ttactgctcc aatcggcgat 554041 gttgggatac cacatcgtcg agctgaataa tgctccgtgg agtaatacaa gcggcggggc 554101 atcctctggg ccgcttgcaa tcacatgtgt ttgaccaaaa cgagtagata tatagaatga 554161 tttacaacgg accggccaaa gactaaggct ttcattataa gtttgataat agcggatacc 554221 gttgtcactt aattcgggaa tactagatga atggtttgac atacaaatgc ccctcccaat 554281 tttgtttaaa tgaatgtgcc gtttcgtgat ggggaatctg attttgatat aacagacttt 554341 atttacaata taatacagtt gttattagac gtcaaatcca agatgaaaag gaaaaaaacg 554401 attgaaacag attattgaaa atcaatataa cagaatatta acctcctttg tggagccgct 554461 tcattaaaac cgcaatccaa atgcatgaat cacaaaaatc acaacaggag ggatcaggag 554521 ggaaggcagc agattcagtg ttttgaactt cttgattcca agaatgctta gacctgaact 554581 gaggatgagt atgcctccca caattgtgat ttcattaata aggtctgtat tgattgcgct 554641 ctccattact tgtgcaaata aatagatgga gccctgccag gaaaataata caagtgcggc 554701 agccgctatt ccaaaaccaa aagttgaagc gagcacaatg gaggtgatcc catctaacat 554761 cccgtttgtc agaaggtatg tataatctcc atgcaaagcg gcttcaacag ggcctaatat 554821 tgacagcgaa cctatacaaa ataataagac cgcagttgat aagccctctg ctaaattgct 554881 tttagaaaat ttgttcacca gcttgttgaa tcgtaattct aaattgatga tctggcctag 554941 caaacctcca atggctaaac tcacgatgaa tagaatgggg tatttactat caggcaaatg 555001 ctgtgtaatg gcgttgatcc ccagtgcgac cgcagcgaat cccattgcct gcatcaaaat 555061 atcctggtat tcatctttaa tgcctttttt gaatatcccc ccgattatgc ttcctgcaat 555121 gatcatcact gtgttaaaaa tcgttccaaa cataagcttt ctcctccaaa aatcattcct 555181 gcataaaaaa taaaccctct agttagtaga gagtcaaggg agatcaaaac atattcatga 555241 gattatttga tgggcagcag gatttcagtc acgtaattat ctaggttatt cgtaatgcca 555301 taatcaatga gtgtgatttc gattgagtcc cctgctacct cataatgatg ttctttcata 555361 tatgccagta attttttgta gtatggttcg gcttctggat gtgacccttt aaacctaatt 555421 tgcagatatt ctcttgaagg aaagatgatt tctgaagaag ttttttcatt ttcatcttca 555481 agaatcataa atatactgga atatttgtca aactgttttg ctttcacatt tgctgcagaa 555541 atggataaac caatcttgcc tatgaatata tcttcgttta cattcaggtg ggttctcaat 555601 tcagctaacg aatgttcgat atcatggccg agaacatatt catgctgcaa ataggccaca 555661 cgcattgcgg gaagtttgat ttttgaaatt tgatgtaacg gcatgttaac ggcatcttct 555721 atatgtgtga tgcgtcggga gatctttcgt tcaatgcgtt ccaattcttt cttcttgcga 555781 tcaatttcaa cctgctggct ttttagtaaa tgaagaagag tgtttgtatt ttgagagtta 555841 taaaaatcaa gaagcttatt gattggcagg cctagggccc tcaaatactt gatggtatcc 555901 agccgctcaa actgttgggt agaataatat ctatagttcg tttgctcatc tttatattcc 555961 ggtttcaaaa ggccgatttc atcataatac cgaagagcag agattttcac attgaataac 556021 tttgacactt ctccaatcga aaaaaattcc ttcattctaa caacctttct gtcctatgat 556081 tgatatacac acattatata gtacggcgag tactaaaggt aaagtttgca gcataaagaa 556141 aaaactcctt ctaaaaagga gcttttcatt cttcgaaata aggatttaca tggatgagca 556201 cttcttctac atctgaaaac tgtcttttga tttcatttcg aatttcgcgg gcaatgtcgt 556261 gtccctgctt aattgtcaaa tcatgatcca aagataaacg gacatcaagc aatttatagt 556321 ggccatgttc tcgcgcgcgg attctatcaa ttcgttttac ctgatcacat tgaaaaataa 556381 cagctttata ttcctctatc agctcgggat caacactctt ttccatgagc acatcaacag 556441 acggcctgat taattccatt gaaatcttaa aaatgaggta agcaacgatt gcactggcaa 556501 tggcatcggc gtacaacaga taggaccatc cacggctgtt tccgatgata gccaacagga 556561 cgccgataaa agcggcaaga gaggcaacga tatcgccttt atgatcgtac gcaatcgcta 556621 taatcgcttt gctgttccat tttttccctt gctttataga ataacgatat aagatttcct 556681 tagccacgta cgaaatcaga gccgcaaaca atgcgctgta ttggggaacg cttggccctt 556741 taacaaagga cagaatcgct tctatgagga tataaacgga tacgatcact aagataattc 556801 ctacaatcgc ctcactaatg acttcagctt ttccgtgacc aaaaggatgg tcttgatcgg 556861 gcggtttatt ggaaattccg atcactgcca agactgcaat cgaagcaacg acatctgccg 556921 cggaatgtat tccgtctgca aacacggctt cactatcgcc taccagccca aaaaagacct 556981 ttcctgccat taagatcaga ttggcgatca atgcaatcaa agcaactttt ctgcttattt 557041 gttctctttc acttgccatt ttttcctcct ataaaactgc acaaaaaaat aggagtgctc 557101 tatatacgct ctccgtatcc tttcctgtgt aatcactttg tttatcatac caattcaatt 557161 tcgagtgggt ctatagcaac gttgtttcct gtttactaat aaataaggtg acagaaaaaa 557221 agttggagct atgctaaaaa ggtcatacag caaacaaatg agttcttatg taacaacagt 557281 gatgattcgc tattaaaatg ctgccgtcag tgaaaaattt ccacctaatt ttcaaaaacc 557341 tattgacatg agaagatctg tattttacta ttatctcata ttcaagatat tttaatttga 557401 gatatttggt cggaaagatc agcgatcaag cgcaactcta agtgttcaat cgttgtcagt 557461 tcttttacac aatattcaat atgatttttt ataacataat atctcgaatt cgagataaaa 557521 gggagtgtag cgtaatggct gaatttactc atttagtcaa tgaaagacga tctgcaagca 557581 attttctttc aggtcatcca atcacaaaag aagatctcaa tgagatgttt gaattggttg 557641 cattggcacc atcggctttt aatttgcagc atacaaaata tgtgacggtt cttgaccagg 557701 acgtaaagga aaagctgaag caggccgcaa acggacaata taaagtggtt agctcttctg 557761 cggttctctt ggtattaggg gataagcagg catatcaaca agcggccgat atctatgaag 557821 gtttaaaggt attggggata ttaaataagc aagagtatga ccacatggtg caagacaccg 557881 tttcgtttta tgaaaacagg ggagaacaat ttaagagaga tgaggcgata aggaatgctt 557941 cactttctgc gatgatgttt atgctgagtg ctaaggaaaa aggctgggat acctgcccga 558001 tgatcggctt tgatgcggaa gccgtaaaac ggattttgaa catagacgac caatttgagg 558061 ttgtcatgat gattacgatt ggaaaagaaa aaacagagag cagaagaccg cgcggctacc 558121 ggaagcctgt gaatgagttt gttgagtata tgtaaaagga gcggataaaa atggctaaaa 558181 aaacgatggg aattcatcat attacagcga ttgtcggtca ccctcaagag aacacagatt 558241 tttacgcagg agtgcttggg cttcgtttgg tcaagcaaac tgtcaatttt gatgacccag 558301 gtacgtatca tctttatttt gggaatgaag gcgggaagcc gggaacaatc attaccttct 558361 ttccgtgggc cggagcccgc caaggcgtca ttggagacgg tcaagttggc gtgacttcgt 558421 atgtcgtgcc gaaaggggct atggcatttt gggaaaagag actagaaaag ttcaacgttc 558481 cctacaccaa aatcgagcgc tttggggaac aatatgtaga atttgatgat cctcatggac 558541 tgcacttaga aatcgtggaa agagaagaag gagaggctaa tacgtggact ttcggagaag 558601 taacgcccga tgttgccatt aaaggttttg ggggtgcaac cctattatca gagcagcctg 558661 acaaaaccgc tgacctttta gaaaacatca tggggctgga gcgagtcggc aaagaaggag 558721 acttcgttcg ttatcgttcc gccggtgata tcggaaatgt gattgacctt aagttaacgc 558781 ctattggccg cgggcaaatg ggggccggaa cggtgcatca catcgcttgg cgggctaacg 558841 atgatgaaga tcagttagat tggcaaagat atattgcttc ccacggatat ggtgtaactc 558901 ctgttcggga tagaaactac tttaatgcca tttacttcag ggaacacggg gaaatcctgt 558961 ttgaaatcgc aactgatccc ccaggctttg cacatgatga aacacaggaa acaatgggcg 559021 aaaaactgat gctgcctgtg caatatgaac cgcatcgcac acaaattgaa caagggctgc 559081 tgccgtttga agtaagagag ttagattgat ttgacacata aaaaataaag aaacatatat 559141 tcaattgatg attgctggat ggtactgtca gcaaagaatc agataaaatc aaagatgagg 559201 agagatacaa atggaagatg caggactgtt gcttattcgt ataatgattg gtgtggtgtt 559261 tttgttttat ggcacacaaa aattattcgg ctggtttggc ggatacggga ttaaaggaac 559321 cggacaatgg ttcgaatcaa ttggggtgaa accaggaaac gttgcggccg ctctatcagg 559381 tcttggggag ttagtaagcg gaattctatt tattttaggc gtattcctcc cgcttggagc 559441 tgctatcata acaatcatca tgttaggtgc tatcgtaaaa gtccatggag cgaaaggttt 559501 tgcgaatggc gccggaggtt ttgaatataa cctggtgctc attgcagttt ccataggggt 559561 tgcactcatc ggttcaggag cttacgcttt gcatttttaa tacgaaagta tgtaagaaca 559621 gttgctgctt gtcagtaact gttcttttat tttcacattt tcggcaagct tgcaggtact 559681 ctgcaaagca aaaaagcgga tatcataaat ataaatctgt atagtgaatg atacgtattg 559741 atgagcttgg tcatgaaaaa cagacctatt tgaaggagta aatggatgaa agagatgaca 559801 ggattacatt cattagtttc tatagaaaac tttatcaaac agcacaaatt cagttttatt 559861 tatatatcaa ggcctggctg tacagtatgt cacgcagttc tgccccagct cagaatagta 559921 ttggatcagt ttccaaacat caaattgggg catatcaatg ctgacgatgt agcagaggtc 559981 gccggcagat tttcagtttt caccgttcct gtgcttcttt tgttcattga tgggactgag 560041 tttctaagag aagcccgttt tgttcatttt gaacagcttg aacaaaagct gaaaagggtt 560101 tatcgattat atgaaggcga ataaaggaat aaggcaaaaa aagaactcaa atgagttctt 560161 tttttattct tcactaggcg aagaagggtt atcaacctgc ccttgatcac ttgtatcatt 560221 atcacaactt gctgaaataa taattgaatg agaaggagag taatctccta atgtgaaatt 560281 cactccgtaa tttttgctgt tcgcagtatg gctgttttgc aagttttgtc cgatatctgt 560341 attggcgttt tgtgtcattc catttatcgt gagatttgag atgttgattt gagatcgcat 560401 gcttcaaaaa ctcctttcac tcagaagtag ctgtcataaa ggacgctggc agtctattta 560461 cttctatgat attgcgtttt tatatcattg catcaacata atggtaaaaa taatagcgag 560521 tgaatgatca tcttttgaag atgatcaacc tatcagcaga aataaagccg cctgataaag 560581 aggcggcaga tcgttatatg tcatctatga atttgatgta tcgtttttcg tttgcctgaa 560641 ggataagata gtcgttttta atgatgagta ggagcctata gcagcgtagc cataaaacca 560701 gcccataaat acgccagaaa agaggctgtg tcgatggctt atgaaaacag aaatgacaag 560761 gcctgttatt aaggcaactg acggtacaaa agttttgggg attttcaata atattttgag 560821 gatttgggtt atcaatatga tgattggaac agctatcaca gcatcccaaa agttcgtgtg 560881 aataattgga aaagccatac ggcacctcat gaagtgttta tttcttaatt tttacgctaa 560941 aagcttggaa agcagctctt ggatcgcata tgttacattt tgggcttgat tggcggagct 561001 tgtttggctt aaagcattgg attcaaaaac caaacctgta ttactcccac cggaaccctc 561061 tgttgtttta gacacagaga acgggctgat ggaaactgca aatccgttat taaaaacgct 561121 gttcccggat atcgaatgaa tataaactgg gaatttcatc attcatctct cctctctgtt 561181 atgactgttt atacaatatg gtgtgtgagc agcagttgct taaacaaaac ggcaaaaact 561241 ttcagtaaga gacaaaaacc tgcaaaatgc cacaagcgcc ttttgttaat gcagcttttt 561301 agggacgttt tttttatttt ttttgccaac ttcatcaaaa atattctgat tgccagactg 561361 ggcttgtccg tccttattta tgaaatcggg gtgaatgagt tttttcagat ccctgactgt 561421 taaaggcttg gcgtcatcag ttaattctat tcctaattgc ccgtttgcct ctaatgtcgc 561481 aattttgaca tcttgtatag ccgtaacgcc gtgaagcctt agctgcattt caagctggtc 561541 agctgtaagt ctcatcttct ttaagttttc gatatgaagc tgtccgtttt caatgacgat 561601 ttttgctttt ccggttaaca tcttttcaat ggtgttcgat ttcatttgga tccattccat 561661 aacgatgagt gtgcttgtga aaattgccgc tgcaattaat gttttgaaga ggctgtactc 561721 gatgattggc tgaacgataa tagttccgat cgaaatcatg acaaccgttt gagtcgacgt 561781 catttgtgcg attgatttcc ttcctgaaat tctcagcaaa atgaccccgg ctacaatgag 561841 aacaagagat tcccaagtga aattcatgct accacctgac caatgatgaa ttagatttgt 561901 catgggattg gcttttcttc cggccaatcg caatttaata tatccgaaag gcagtcggtt 561961 cattctgtcc tgaaccgaac aatatttttg gtatagatgg atatattaag ccaaacaatg 562021 atagcaacag gagttttttg gccgaaacaa tctgggaagc ggggagcgcc ataacatgat 562081 tgaacttgaa gttgtcatta gaacggttgc cagctttggc ttgctgttaa tcgcagaacg 562141 aattttaggc aaacagacaa tctctcaaat gacgattttt gattttattg cggcgatcac 562201 actaggggcg attgctgccg gattagctta caatacttca ataaaaccgc acaatatggc 562261 catttcgttt agtatttttg tgctaaccat ttttctaatt tcgtttctgt cgataaagaa 562321 caggaagctg aggaaatttt ttgccggaga tccaacagtg ctgattcaaa acgggaagat 562381 acttgaatca aatatgagga aaatgcgtta cacacttgat tatttaaatc agcaattacg 562441 ggaaaaagaa atatttaata tcgaagaagt tctttttgcc attcttgaaa cgaatggtca 562501 gctgactgtg ttaagaaaac cgcaattccg gcatgtgacc aaacaggatt taatgattgc 562561 ggtaaaccaa gaacaaaggc ttccgataga acttattatg gacggagaaa tcattgagaa 562621 taatttaaag cagaatcgtt tgacggaatc ctggcttttg gaagaattgc gaaaaagaga 562681 cataaaggtg aaagagaccg tgtacgcagt gctgctgggt aatggggata tttatgtgga 562741 tcaatataaa gaccatatat cagtccctat ggataaggaa tgaaggaaca atcaatctta 562801 aagcccctta ttgaacgcaa cggtttcaac ttgtcttggg tacgaaatat gcagaagccc 562861 gtttaacagc tgaatctgta acaaatgagt ttcagcggct tcgggaagct gaatgattcg 562921 ctcaatttct ccgtaatacc gttcacgcag cacttccatt tcggctggaa aaacaggcgt 562981 gatcgttcct ttgatcagca gctgggtttt agacagtaaa cggatcgtta attcttcctc 563041 atacacaccg ggcatttcca caatgataaa attatattcc tcatcttgat aaaagtcgta 563101 aacaaacgta gaagcttcgg aatcaaaaaa atgttccggg gctttatatt tgagcacatt 563161 tgtccaaaag tcactttgtt tatattcatt cgtaatctca agccactttc gaattttttc 563221 gaaatccata tgagattctc cttaaatttg atttgaaatc ggcgcagaag ggtttccgat 563281 ttggtcttgg tcactaacgt ctgaatcaat atttccagtg tttaaaagtg aagacgtagg 563341 cgaaagatcc cctaaggaaa agtttgctcc aaaatatttg ctgttcgcag tatggctgtt 563401 gtgcacagtc ggaccgacat ctatatttcc gttttgcgtg acgccgttga tcttaatatt 563461 tgcgatatta atttgatatg gcatagacga aaccccttta atctaaaatt ggcggtggtg 563521 caatcggagg agcattaacg ttggatgtat cagagttgcc gatagatgtc tggtcattta 563581 catcaggatc gtttaagaag ttttccatta cggattctgt aggtgatgta tcaccgaaag 563641 aagagttggt cccttgagat ttttgattgt tggtagggct gttataagca gcttcgccta 563701 ttgtaattga accattgccc gaaatactgt tgatcttcaa ataatatagg ttgattactg 563761 tagacggcat cccatcacac ccttccatct ttctgtacag tacattatgc gccgctgcac 563821 ccaattgttc cttgcattta cgggcaaaac tctatctggc cccggagtga tgctcaatta 563881 tcagtgaatg aaaagccatt gatataggaa tcaatgaatt gattcagtta ttcgaaatgc 563941 atgagacctt ttaataaagg aagctggcaa acaggatcag tttgaaataa ttgacaatga 564001 agctaatgcc atgaaataat actcgtgagt aacattactc gtgggtatta tttttggggt 564061 ggtcctagtt gaaaagtaaa ggagtagaaa gccgaaaacg attacttaaa gctgccgcta 564121 atgaattttc ggttcgggga ttccatgacg cgaaggtaag tgaaattgtg aaaaaagctg 564181 ggttcacgca gccttcattt tacctgtact ttcaaagcaa agaagccatc tttgccgagt 564241 taataaccga ttttcactct cgagtcagaa agctgacaga gtcacttctt ctggaaaacg 564301 gattaaacac ggaggatgtg tcaaaacggg tactgctagc tgtagagact gtttttcaat 564361 ttttggatga ggacaaggat ttaaccaaga tcggcttttt tctcaacccg gaagcaaaac 564421 aaatgaaaaa agacttggcg atggttttga aagagaactt agaagcagaa cagcggcttg 564481 gctattttca ctctgaactg gatatggaaa ctgtcgctga gtgtttggtc ggcatgattg 564541 aacatttaac cgaatcattt ttgttaaccg gaatcaaaga tccggcaagc ctcgcagcag 564601 aggttgtgaa tcttttaatt tacgggatgc ttccgaaagg gaatgatgta agatgatatc 564661 tattatgatg aaagtcagtt tggcagtttt tatgcttgcg ggaggcatca taaaggtaag 564721 ccgcgttccc tttcaagttg agcattggcg gcattatcaa tatccattat ggtttctgac 564781 tgttactggc attcttgaaa tagccggggc acttgctatg acagcgggaa tttggaatcg 564841 gtatgcagca attggagcag gtgttctgtt tgtcgttctc atggcgggag caattcatgc 564901 gcatatgttt cgagcaagac aatctgtcat catggcgata caagcgatga tttgtttgat 564961 tgtttcaatc atgatcatca tggggagtta cacgtaagct tttcactaat gtttaagaac 565021 aagcccattt gcaggaaatc tccttttctt atcgaataat agaaagtcca ggaattaact 565081 gaatcagtaa aatagagctc catttctgtg ttattcgtcc ggcatcagct gggctttttt 565141 tataaaggag gaatacagga tggcattcac tttggaagac atgactgagg aagagttcga 565201 agcctttcgc gggatgtccg tgcaaaattt tgcgaaacaa aacataacgt caggaacttg 565261 gacggaaaaa gaggcatttg agaaatcgga gcaggcatat gagaacatga ttccgaatgg 565321 gcgagacagc agcaatcatt atttttggaa catcacaaat gaccaaggag aaagaatggg 565381 ctggctctgg ctgtatgctg atccattaca tccgcaaaag gaagcgttta tctattcctt 565441 tggattgtat gaagcctttc gcggaaaagg acttgctcaa ttggcgcttc aaacgcttga 565501 tgaaagagca agagagcttg gtgcggaaag gctggctcta catgtatttg cacacaacga 565561 gacagccgtc tatctttatc agaagatggg ctatgccatg accaatatac gtatgcggaa 565621 acagctatgc tgaaaagccg cttacgttac ccaaatacaa catgcctatc tggaagcggt 565681 ggcagggtac tataagtcat cattagaaag attaaggtca tgggaggctt gaacatataa 565741 agaaaaagga caacagctgt tgtccttttc aatgccgctt gaactttctc cctcagtctt 565801 ttttgtcttg atgatccagc tcttttattc gtttcgtaag ctcattgaaa gcctgatcaa 565861 gctccttata ccctttatca tttggcgtca taaaactgag ctttcccagc acttcttgtc 565921 tttctgtctc aagctttaac cgaagctcct cccgctcatt tctttctgaa ggaacgtcgt 565981 ttaactgctt ttcgatgccg ttgtttgaga tgacgagttt actgtttgtt gttttttcga 566041 gaaagtatcg gtcatgtgaa accgccagca atgtgccgct gtattgtgac agtgtttctt 566101 ccagctgttc gcgtgacggc aggtcgagat ggtttgtcgg ctcatctaaa atcagcacgt 566161 ctttttcctc cagaatatat gccatcagct tgatctttac acgctcaccc atactcatat 566221 gcttgatcgg ttcagtccat tgggcggctg taaaacctaa gtgcctcatc agattttgaa 566281 cgtgccccct tgctttgaat gtttcattct caaataactc ttccggtgtt tgttctaaag 566341 gcaaatcaaa cacctcctgc gttaaatagc cgatgtttgc ggacggcgac acccatacac 566401 ttccttctgc tgtttcctgt cccagaatga tgttcagtaa tgtcgttttt ccgctgccat 566461 tggggcctat gatcgcaacc ttttcgccgt gctgaattgt aaagtttgcg tttttaaaga 566521 gagtcctttc tccaaacgct tttgttacat tctgaacttc taaaaaacgt tttcctgttt 566581 tgtgggttgt atcgattgaa aagcggactg tatattctgg ggtaacgggt tccgcctttg 566641 ctttttcaag ctctttttca agccgcttct gcttggattt tatctgggca tccgtacgct 566701 tcgcttttac ccggtgatat tctttaaacc cttccttttt cgtcgattga gcatgggctt 566761 tttccgacca agaagcgagc ccattcattt gtgcttcaat ccgttcaacc attttttgct 566821 gcttttcata ttcacgctgc tgggtgagtc ttttcttctc ccggaacttc atatacccgg 566881 agtaattccc tttgaattca atcagcgtct gatcctcaag cgaccatatt tttgttgcgg 566941 cttcgtctaa aaaatatcga tcgtgagaaa cgagaatcac agtgccgtta taatgtttca 567001 gctgttggat gagaaattgc aagctttttt catcaaggtg gtttgtcggt tcatctaaca 567061 gcagcagatc tgcatcctct gatagtcctt tcgccagccg cgctttcagt ttttcaccgc 567121 cgcttaactg atgaaaatca cgaagaggca catgccattt ctccagtaac ttcttttcgg 567181 caggtgtctg atccgcaaag gaatacgccg cggtttcctg ttcaaccaaa gccagtttta 567241 tatccttccg aaggatttga ccctgtgcag gggctaagtc attgtgaatg aggtgcagca 567301 acgtagattt cccagcgccg tttttgccga taatcccaat gatatctcct tgctgaacac 567361 tggcgtttac atgtttaaaa acagtttgat cctttacttc atagctaacg tttgttaatg 567421 ttacgatctc tttcatccat atccctcgct ttaaagggag aataaaaaaa tcctcccaaa 567481 tgtgttggaa ggattagccg tgcctgtgca tgatcaaata agctattttt tataaatagc 567541 agtgtcgtat atatagaaaa tgggcagact aatcctattt tttgatttga aatattgatt 567601 tcaaacggta aaaataagat tagttaatca ttgtccaccc atcatccctt cttgttttga 567661 ttacaaacac tatagcatac ctttaaattc aaaagcaaag gtcattttca tcaaaaaaac 567721 tcctgctctc atttttgagg caggagtttt gagtcttatt gatgcttcgc ttttctcact 567781 ttataaatca caatcagcaa aataaaccaa accggtgtga caaataagga aacacgagta 567841 tcctgtgcca gtgccagcac aaccagaaca aacgccagga acgcaagaat caggtaattt 567901 gtaaacggat aaagcggaag cttaaacttg tttgttttcg ctaattcagg tcttgttttg 567961 cggtatttca tatggcagat gaccgtaatc ccccaaatgt agataaagca tacggttgaa 568021 atacttgtga tcagggtgaa tacgccttct ggcatgatgt agtttaacgt aacaccgatt 568081 aaaatcacga tagctgaaaa gaataaagca tttctaggca ctttacgctg agtcagtttc 568141 gccattgact caggcgcatt gtgatctttc gccagggaat agaccatacg gcttgtactg 568201 aatacagcgc tgttgcatgc tgaagcagcg gatgtcaaca caacaaagtt gataatactt 568261 gcagccccga cgatgccaac agcgacaaat acttgtacga atgggctttc gctgggattg 568321 atgatatccc aaggatagat gctcataatc acgagaagag ccccgatata aaaaagcagc 568381 acacggacag gaatattgtt gatcgcctta gggattactt tttcagggtt ttctgtttca 568441 ccggccgtaa gcccgacaag ctcaatgccg acaaaagcaa acacaaccat ctggaacgag 568501 aggataaacc cgtgcatgcc attcgggaac aggcctccgt ggctccagag gtttgtgaag 568561 ctggacactc ctgagcttgt ggaaaagcct ttgaaaatca tcacaaggcc aatgacgatt 568621 aacgccaaaa tggcaatgac tttaatcaaa gcgaaccaaa attctaattc tccaaaaagc 568681 ttgactgtcg ccagattcat aatcagtaaa ataataagag cgattaagcc aggcacccat 568741 tgcggcacac ccgggagcca atattgagtg tagagcccga ctgctgtcag atcagccatc 568801 gcaatggaaa tccagcagaa ccaatatgtc cagccggtga taaaagctgc catatcgcct 568861 aggtagtctt gtacaaaatc cacaaaagag tgatagttca agtttgataa cagcagttca 568921 cccagcgatc tcataattaa aaagcaaatg atccctgtga tcatataagc aaataaaatc 568981 gaaggtccgg caaaatgaat cgatttgccc gagccgagaa ataagcctgt cccaatggct 569041 ccgccgatgg cgatgagctg gatatgcctg tttttcaagc ctctctgcaa cgtttgctga 569101 tttatattgt ctttcgtcat gtcgtctgtc actttatgtg ttcctccatt gaaaattgtt 569161 tattgagtca gcaatctatt tttaatgatt attataacac taaaatttct atctttttta 569221 ctaaaaaagg attgatgaaa agaattttaa tgtgatttgg actatttccc gaaaaaagcg 569281 gctccattta gggagccgct tttttatgct ttttcagttt ttgtcataaa caggtagagc 569341 ccgtaatctg tcggtgcgga tgcgtagcct gcctgccgca gcattgctgt gatattgccg 569401 cggtggtatg tcccgtgatt gacaacgtgg ggaagcagtt cggaaacagt tgttttcatg 569461 attccgcttg agggattttg aatctggagt ggcttattga gctgttcttt ttgctgtaaa 569521 aatagtatat agcgctcgga taacctcaga aaaaggtctt ccatttcctc tatttcttta 569581 gcctctgtct gttctttaag ctgttcagct aaagccaacg catcgctcaa ggttttgccg 569641 gaaaacactt caatccagcc gagatcagaa agataaacat gagacaatac atgggatatt 569701 gacggaaaca cgctttgaat ttcttgatgg tatatctctt ttggaagctc ttttaatcgg 569761 ttgaatattt gttgattggc ccagacgtta tattcataca atttgaatgc aaaatctgac 569821 atgttaaaat tccccctttc gtgtgtatag ctttcattat acacgaacat gagttcttat 569881 gtagagtgct cgaaaataaa atttgttgac atatatagtt tagaggaata aactaattga 569941 cattgaacat aaagtttagc ggggtaaact ataatgcgtc tgattagagc tcatttcata 570001 aattcttgtt ttttgcagca cacctgtcga ctcaagaagc aggttatcca gcaggtcagt 570061 aattaagttt ccgtggttat acacccacga cccgttccac ggattgcccc ctgcatcaac 570121 aggaagggaa ctttgcgctc caataatata atgatgagga ttagcatgtt taaccgcttc 570181 atcaagtggc gcttgatctg taccttgact gccgacacct tcaccgcctg attcatctaa 570241 taaagcattg attgtgtttt gaaccagttc aacgtgggca atctcctcta aaaaaatgcc 570301 gcgaagcaga tcgcggtact gtttctgctt tcctctgaaa ttagagcttt ggaaaaaaac 570361 tgcatcattg tacgcatttc tccgtaatga ccgcctaata tctcctgcag gaccttagca 570421 gctgccgggt ctggcttgtc cggtttaatg atattaatca gttcctcttt gtagtaatac 570481 ataacacgcc tcatttcttc ttaagagatt ttcttatatt atttgtaaga tgagataaaa 570541 tatatacatg ataagcatgg gaaggcgtga aagaagaaaa taaaaaaata caggaaaagt 570601 gttgaccaaa taaaacaggc atggtatatt attaaacgtc gctgatgaac agcgtgaaac 570661 aaaacagaaa aacaaaaaag ttttcctaag gtgtttacaa gattttaaaa atgtgtataa 570721 taagaaaagt cgaattgaaa aagattcgaa aaaacattaa aaaacttctt gacttcaaca 570781 tcaaatgata gtatgatagt taagtcgctc aataagcgcc cgtagctcaa ttggatagag 570841 cgtttgacta cggatcaaaa ggttaggggt tcgactcctc tcgggcgcgc catataagat 570901 accacgcggg tgtagtttag tggtaaaacc tcagccttcc aagctgatgt cgtgagttcg 570961 attctcatca cccgctccat tattgaatga tctttgaaaa ctaaacaaga caaaacgtac 571021 ctgttaattc agtttttgaa aatcgcacag cgatgtgcgt agtcagtcaa actagggcct 571081 gcacgatgca ggtcacacag gtgtcaccgc gggatgcggt ggacttaacc tgtgatccat 571141 ttatcggaga gtttgatcct ggctcaggac gaacgctggc ggcgtgccta atacatgcaa 571201 gtcgagcgaa cagatgggag cttgctccct gatgttagcg gcggacgggt gagtaacacg 571261 tgggtaacct gcctgtaaga ctgggataac tccgggaaac cggggctaat accggatggt 571321 tgtttgaacc gcatggttca aacataaaag gtggcttcgg ctaccactta cagatggacc 571381 cgcggcgcat tagctagttg gtgaggtaat ggctcaccaa ggcaacgatg cgtagccgac 571441 ctgagagggt gatcggccac actgggactg agacacggcc cagactccta cgggaggcag 571501 cagtagggaa tcttccgcaa tggacgaaag tctgacggag caacgccgcg tgagtgatga 571561 aggttttcgg atcgtaaagc tctgttgtta gggaagaaca agtaccgttc gaatagggcg 571621 gtaccttgac ggtacctaac cagaaagcca cggctaacta cgtgccagca gccgcggtaa 571681 tacgtaggtg gcaagcgttg tccggaatta ttgggcgtaa agggctcgca ggcggtttct 571741 taagtctgat gtgaaagccc ccggctcaac cggggagggt cattggaaac tgggaaactt 571801 gagtgcagaa gaggagagtg gaattccacg tgtagcggtg aaatgcgtag agatgtggag 571861 gaacaccagt ggcgaaggcg actctctggt ctgtaactga cgctgaggag cgaaagcgtg 571921 gggagcgaac aggattagat accctggtag tccacgccgt aaacgatgag tgctaagtgt 571981 tagggggttt ccgcccctta gtgctgcagc taacgcatta agcactccgc ctggggagta 572041 cggtcgcaag actgaaactc aaaggaattg acgggggccc gcacaagcgg tggagcatgt 572101 ggtttaattc gaagcaacgc gaagaacctt accaggtctt gacatcctct gacaatccta 572161 gagataggac gtccccttcg ggggcagagt gacaggtggt gcatggttgt cgtcagctcg 572221 tgtcgtgaga tgttgggtta agtcccgcaa cgagcgcaac ccttgatctt agttgccagc 572281 attcagttgg gcactctaag gtgactgccg gtgacaaacc ggaggaaggt ggggatgacg 572341 tcaaatcatc atgcccctta tgacctgggc tacacacgtg ctacaatgga cagaacaaag 572401 ggcagcgaaa ccgcgaggtt aagccaatcc cacaaatctg ttctcagttc ggatcgcagt 572461 ctgcaactcg actgcgtgaa gctggaatcg ctagtaatcg cggatcagca tgccgcggtg 572521 aatacgttcc cgggccttgt acacaccgcc cgtcacacca cgagagtttg taacacccga 572581 agtcggtgag gtaacctttt aggagccagc cgccgaaggt gggacagatg attggggtga 572641 agtcgtaaca aggtagccgt atcggaaggt gcggctggat cacctccttt ctaaggatat 572701 tatacggaat ataagacctt gggtcttata aacagaacgt tccctgtctt gtttagtttt 572761 gaaggatcat tccttcgaaa cgtgttcttt gaaaactaga taacagtaga catcacattc 572821 aattagtaat acaagatatc acatagtgat tctttttaac ggttaagtta gaaagggcgc 572881 acggtggatg ccttggcact aggagccgat gaaggacggg acgaacaccg atatgcttcg 572941 gggagctgta agcaagcttt gatccggaga tttccgaatg gggaaaccca ccactcgtaa 573001 tggagtggta tccatatctg aattcatagg atatgagaag gcagacccgg ggaactgaaa 573061 catctaagta cccggaggaa gagaaagcaa atgcgattcc ctgagtagcg gcgagcgaaa 573121 cgggattagc ccaaaccaag aggcttgcct cttggggttg taggacactc tgtacggagt 573181 tacaaaggaa cgaggtagat gaagaggtct ggaaaggccc gccataggag gtaacagccc 573241 tgtagtcaaa acttcgttct ctcctgagtg gatcctgagt acggcggaac acgtgaaatt 573301 ccgtcggaat ccgggaggac catctcccaa ggctaaatac tccctagtga ccgatagtga 573361 accagtaccg tgagggaaag gtgaaaagca ccccggaagg ggagtgaaag agatcctgaa 573421 accgtgtgcc tacaagtagt cagagcccgt taacgggtga tggcgtgcct tttgtagaat 573481 gaaccggcga gttacgatcc cgtgcaaggt taagcagaag atgcggagcc gcagcgaaag 573541 cgagtctgaa tagggcgcat gagtacgtgg tcgtagaccc gaaaccaggt gatctaccca 573601 tgtccagggt gaagttcagg taacactgaa tggaggcccg aacccacgca cgttgaaaag 573661 tgcggggatg aggtgtgggt aggggtgaaa tgccaatcga acctggagat agctggttct 573721 ctccgaaata gctttagggc tagcctcaag gtaagagtct tggaggtaga gcactgattg 573781 gactaggggc ccctaccggg ttaccgaatt cagtcaaact ccgaatgcca atgacttatc 573841 cttgggagtc agactgcgag tgataagatc cgtagtcgaa agggaaacag cccagaccgc 573901 cagctaaggt cccaaagtat acgttaagtg gaaaaggatg tggagttgct tagacaacca 573961 ggatgttggc ttagaagcag ccaccattta aagagtgcgt aatagctcac tggtcgagtg 574021 actctgcgcc gaaaatgtac cggggctaaa cgtatcaccg aagctgcgga ctgttcttcg 574081 aacagtggta ggagagcgtt ctaagggctg tgaagccaga ccggaaggac tggtggagcg 574141 cttagaagtg agaatgccgg tatgagtagc gaaagagggg tgagaatccc ctccaccgaa 574201 tgcctaaggt ttcctgagga aggctcgtcc gctcagggtt agtcgggacc taagccgagg 574261 ccgaaaggcg taggcgatgg acaacaggtt gatattcctg taccacctcc tcaccatttg 574321 agcaatgggg ggacgcagga ggatagggta agcgcggtat tggatatccg cgtccaagca 574381 gttaggctgg gaaataggca aatccgtttc ccataaggct gagctgtgat ggcgagcgaa 574441 atatagtagc gaagttcctg attccacact gccaagaaaa gcctctagcg aggtgagagg 574501 tgcccgtacc gcaaaccgac acaggtaggc gaggagagaa tcctaaggtg atcgagagaa 574561 ctctcgttaa ggaactcggc aaaatgaccc cgtaacttcg ggagaagggg tgctctgtta 574621 gggtgcaagc ccgagagagc cgcagtgaat aggcccaggc gactgtttag caaaaacaca 574681 ggtctctgcg aagccgtaag gcgaagtata ggggctgacg cctgcccggt gctggaaggt 574741 taagaggagc gcttagcgta agcgaaggtg cgaattgaag ccccagtaaa cggcggccgt 574801 aactataacg gtcctaaggt agcgaaattc cttgtcgggt aagttccgac ccgcacgaaa 574861 ggcgcaacga tctgggcact gtctcaacga gagactcggt gaaattatag tacctgtgaa 574921 gatgcaggtt acccgcgaca ggacggaaag accccgtgga gctttactgc agcctgatat 574981 tgaatgttgg tacagcttgt acaggatagg taggagcctt ggaaaccgga gcgccagctt 575041 cggtggaggc atcggtggga tactaccctg gctgtattga ccttctaacc cgccgccctt 575101 atcgggcggg gagacagtgt caggtgggca gtttgactgg ggcggtcgcc tcctaaaagg 575161 taacggaggc gcccaaaggt tccctcagaa tggttggaaa tcattcgcag agtgtaaagg 575221 cacaagggag cttgactgcg agacctacaa gtcgagcagg gacgaaagtc gggcttagtg 575281 atccggtggt tccgcatgga agggccatcg ctcaacggat aaaagctacc ccggggataa 575341 caggcttatc tcccccaaga gtccacatcg acggggaggt ttggcacctc gatgtcggct 575401 catcgcatcc tggggctgta gtcggtccca agggttgggc tgttcgccca ttaaagcggt 575461 acgcgagctg ggttcagaac gtcgtgagac agttcggtcc ctatccgtcg cgggcgcagg 575521 aaatttgaga ggagctgtcc ttagtacgag aggaccggga tggacgcacc gctggtgtac 575581 cagttgttct gccaagggca tcgctgggta gctatgtgcg gacgggataa gtgctgaaag 575641 catctaagca tgaagccccc ctcaagatga gatttcccat tccgcaagga agtaagatcc 575701 ctgaaagatg atcaggttga taggtctgag gtggaagtgt ggcgacacat ggagctgaca 575761 gatactaatc gatcgaggac ttaaccatat ttttgaatga tgtcacacct gttatctagt 575821 tttgagagaa cactctcaat ttgtttggtg gcgatagcga agaggtcaca cccgttccca 575881 taccgaacac ggaagttaag ctcttcagcg ccgatggtag tcgggggttt ccccctgtga 575941 gagtaggacg ccgccaagca ttacttttat catcgcgggg tggagcagtt cggtagctcg 576001 tcgggctcat aacccgaagg tcgcaggttc aaatcctgcc cccgcaacca aatatatggt 576061 taaataagga gtgccctaag ggtgcaacca aaataatcct atacaaatat ggtccggtag 576121 ttcagttggt tagaatgcct gcctgtcacg caggaggtcg cgggttcgag tcccgtccgg 576181 accgccatta atgtaaacga aacgatcatg ttttcgtttt ttttgtgttt tcttttactg 576241 tatcttctgc ttggtgtcat agccaagctt tctttatatc gggaacatct tggatattcc 576301 agcaaaattc gataaactag gaagagcaca aataggcata agcagggttg aaaggaggtt 576361 ttggttcatg gatgaatttg atttgataca tagcattact ccgcggacca ttcaccattc 576421 ttccgttgat gtaggaatag gtgatgatgc agcgctctac actgcgaaac acggcgttca 576481 ggaaattgtt tgtgttgata ctatggtaga agacgtgcac ttcaaattac actattcctc 576541 acctgaagat atcgggtaca aggcgttagc cgttaatata agtgatattg ccgcgatggg 576601 aggcattcct aagttttatc tggtatcact tgcggtacct tcaaaatgga ctgaatctga 576661 aatcaaggcg atgtatgaag gaatgaatga actggcgaaa ctatatcata tggatctgat 576721 tggcggcgat acagtttcta ccgctgacaa attagtcgtt acagtcactg taatcggtga 576781 aattgaaaag ggacaggcct gtttgcgcag cttggcaaaa ccgaatgata ttgtgtttgt 576841 aaccggtgaa atcggttctt ctgcagcagg gctttcttta ttgctggaag agactaatcc 576901 tcaaaactca tctgtggaaa cggattactt tatccacagg cataaacggc ctgagccaag 576961 agtaagcgtc ggcagattat gctcgatttt taaacgggca gctttaaatg atgttagtga 577021 cggattggct agtgaactga acgagattgc agaagccagc tgtgtttcaa ttgaaattgt 577081 tgaaagcatg cttccaattc attctgattt gcctaagctt catcctaact ggaaagaatg 577141 ggctttgttt ggcggtgagg attttgagct gacagggacg gtttcaaatg aggagtggga 577201 agtgttgaag caggagtgcg cagcgcttca tcttcccatt acaaagattg gctatgtcag 577261 ggaaaaaaca aaatctaaag tgatcctaaa aacagatcaa acatcaatga tcttagagaa 577321 aaagggatat aatcatttta aataagacgg gtgactcgtg tgaagcaatt aaaatggaga 577381 actgtaaatc cagaagaaac aaaagcaatt gccaagctga cggcagcgtt tgctaaaccg 577441 ggagacgtcc tgacattaga gggcgattta ggtgcaggaa aaacgacttt tacgaaaggt 577501 tttgcagaag ggctgggaat tacacgtatt gtaaacagtc cgacttttac aattataaaa 577561 gaatataacg atggcgtact tcctctttat cacatggatg tgtatagaat ggaagatgaa 577621 agtgaagatt tgggacttga tgaatatttt cacggacaag gtgtctgtct cgttgaatgg 577681 gctcatttaa ttgaagaaca gctgccacag gagcgactgc aaattgtcat caaaagagct 577741 ggtgatgatg agcgggaaat tacctttact gctgtcggga atcggtatga aatgctttgt 577801 gaggagttaa gtagacatga caatattagc aattgataca tcaaattata cattgggcat 577861 tgcgctgctt cgagaagaca ctgttatagc agaatacatt acatatttga aaaagaacca 577921 ctctgtaaga gcgatgcctg ctgttcattc attgctgaat gattgtgata tggcaccgca 577981 ggacctttct aaaattgtcg ttgcaaaagg ccctggttca tacacaggag taagaatagg 578041 tgtgacgttg gccaaaacac ttgcctggtc tttagacatt ccaataagtg ctgtatcaag 578101 tcttgagacg cttgcggcaa atggccggca ttttgacggt ctgatcagcc caatctttga 578161 tgctagacgg ggacaggtgt acacaggtct gtatcaatat aaaaatgggc ttttagagca 578221 agttgttcca gatcaaaatg tgatgctggc agattggctg gagatgctaa aagaaaagga 578281 ccgccctgtt ttgtttttag gccatgatac ttctcttcac aagcagatga tcgaggatgt 578341 gcttggaaca aaaggattca ttggaactgc cgcccagcat aacccgcgcc cttcagaatt 578401 ggcttttctc gggaaggaaa aggaagcagc tgatgttcat gggcttgtcc cggattactt 578461 gcggctggca gaagctgaag cgaaatggat tgaaagtcaa aagtagggtg ataggatgaa 578521 aacaaaagca gcggtcagaa atatgcggct tgaagatata gatcacgtat acgaaatcga 578581 agcatcctcc tttacgtctc cttggacgaa ggattcgttt tatcatgagc tgctggaaaa 578641 tccgtatgct cattatctcg tgattgaaaa ggacggccat cttgctgggt attgcgggat 578701 ttggattgtg atggacgatg cccagattac aaatatagcg ataaaaccag agtatcgcgg 578761 ccagtcttta ggagaaacgc tttttcgctc agctgttgaa ctgtgcaaag aaaaagacgc 578821 aaggcggctt tcgcttgaag tgagggtttc gaatcatcct gctcaaggct tatataagaa 578881 attcgggatg cagcccggcg gaataagaaa gaactattat actgataacg gggaagatgc 578941 gttaattatg tgggtgacga taaatgagtg agcaaaaaga catgtacgta ttaggaattg 579001 aaacaagctg tgatgagact gctgcagcta ttgtgaaaaa cgggaaagag atcatttcaa 579061 acgtagtagc ctctcaaatt gaaagccata agcgcttcgg aggcgttgtt ccggaaattg 579121 cttcaagaca tcatgttgaa caaatcactt tggttataga agaggcgttt cgcaaagctg 579181 gcatgacgta tagtgatatt gatgcgattg cagtaacaga aggtccggga ctggtgggag 579241 cgcttcttat cggagtgaat gccgctaaag cattgagctt tgcatataac attccgttag 579301 taggcgttca tcatatagcc ggtcatatat acgcgaaccg tcttgtagaa gacatcgtgt 579361 tcccggcact ggcattggtc gtttcaggag gccatacaga actggtttat atgaaggaac 579421 atggatcatt tgaagtcatt ggggaaaccc ttgatgatgc ggcaggagaa gcctacgaca 579481 aagtggcgcg gacgatggga ttgccatatc cgggtggacc gcaaattgac aagctagctg 579541 aaaaagggaa tgacaatatt ccgcttcctc gcgcatggct tgaagaaggc tcttacaact 579601 tcagctttag cggattgaag tctgcggtga tcaatacgct tcataatgca tcccaaaaag 579661 ggcaagagat tgctccggaa gatttgtctg ccagtttcca aaatagtgtg atcgatgtct 579721 tggtaaccaa aacggcgcgc gcggcaaagg aatatgatgt caaacaggtc cttttagccg 579781 gaggagtagc tgcaaacaga ggcctcagag ctgcattaga aaaggaattt gcccagcatg 579841 aagggattac gcttgtcatt cctccattag ctttatgcac ggataatgct gcgatgattg 579901 ctgctgctgg tacaattgct tttgaaaaag gaattcgcgg tgcatatgat atgaatggcc 579961 agcccggcct tgaattgact tcttatcaaa gtctcacgag ataatagcgt gagacttttt 580021 atctgtttgt tattaacaga caattcacaa tttatccaca tatctgtgag taattataga 580081 gatattgatg gataaagggc tgaggtcact gttaataaag tggataaatt cagaatattt 580141 tgtggatagt gtgtataaag cgcttacttt gtttatttat taggggatgt tctgtggata 580201 aaaagcacct ctaaaaagag gtgcttgact tttttaatct tcttctgtgg atagttcttc 580261 ccattcggac aaaagagatt ccagctcctg attaagcttc tcattgtctg catggatagc 580321 ttgtactttt tcatgatcct gatagacttc agggtcacat agcaattcat cattgcggct 580381 gatgttctcc tcaatggttt gaacggtggt ttcaatttct tcaatccgac ggagtcgttg 580441 gcgctctttc tttttccatt ctttttcttc ctcgtaggaa cgtttggagt cagacttcac 580501 tgtagctggc gttttatcag tttcctcttg ctgattcatt ttctccaatt caagctgctc 580561 tgtttttttc tctgtataat aatcgtaatc tcccagatac tcctctatat ggcttgaaga 580621 aagctccaat actcttgtgg cgattctgtt aataaaatat ctgtcatgtg agacaaataa 580681 cagtgtgcct ggataatcaa tcagcgcgtt ttcgagaact tctttgctgt ctaaatccag 580741 atggttcgtc ggttcatcaa ggatgagaaa gttggctttt tgaagcatca gcttagctag 580801 agccaatctt gctttttcgc ctccgctcag tgaatgaact ggtttcagca catcatctcc 580861 ggagaataag aaatttccga gacacgttct gatttctttt tctgggagcc cggggtactc 580921 gtcccacagc tcatcaagga cacgtttaga ggaagtcaac tcagcctgtt cctggtcata 580981 atagccgaca ctgacatttg agccgtaaga aattgttccc tgatctggtt ttagggtgtc 581041 tattaatgtt ttcagcaatg tcgatttacc tattccgtta gggccgacaa gcgcagcgct 581101 ttctcctctt gtgagcatga atgacacttc tgttaaaagc ggcggctggt tttcatagct 581161 gattgtgaga tcctgaacac gaaggacttc atttccgctc tgttttgtaa tatcaaaatg 581221 aaagtttgcg gatttttcat cgccaagcgg ttttgacatg acatccattc gctcaagctg 581281 ctttctgcgg ctttgcgccc ttttggtggt agaggctctc gccagatttc gatctacgaa 581341 gtcctgcagc tttgcaatct cgtcctgctg cttttcatac attttcagat ctttttcata 581401 ctgcgcggct ttttggtcga gataagcgct gtagttgccg tgatactttt tgctttctgc 581461 tcttgatacc tcgtatacct ggtttactac tttgtccaaa aagtagcggt catgcgaaac 581521 gatgagaatg gcgcctgaat agccttgtaa ataatgctca agccaggtaa gcgtatcaat 581581 atccagatgg tttgtcggct catcaagaat gagcaaatca ggctgtgtta atagaagctt 581641 acctaaagcc agtcttgttt tctggcctcc gctgaggctt tgaacctgtg tagaatcgtc 581701 aaaatggctg aagccgagac catgcagcac agatctaaca tccgcttcat attgataacc 581761 gcctttatct ttgaattcct gctgaagacg gtcgtaggtt ttcatgatgc tttctaattc 581821 acccgggtca gctgccgcca ttttttcttc catagcccgc atttcctttt ccattgcttt 581881 taagtggtca aaaacagtca gcagctcttc ttttatggta agcttagaat ccaagccagt 581941 atgctgggcg agatatccca ttgtaatatc tttcggttta ataatttcgc ccttttcata 582001 cgaaagctgg cctgcgataa ttttaaggag cgtggatttt ccggcgccat ttcttcctac 582061 aatggcgatg cgatcacgat ttctgacttc cagctttata ttgtttaaaa tagtatcagc 582121 accaaatgat ttggacagct gattaacttg taagatcatc atattatttc acctctgcta 582181 taataagtta agtgtagctt atgaaccaga agtcagcaaa caatacattg gccatataag 582241 acatagagaa gaaaatagtg tatgatctgt ttaaggagcg ttttaatatg aatggatttt 582301 ctcattttaa tgaacagggc agagcccaga tggtggatat tagcgaaaaa tcttcgactg 582361 tccgtactgc ggcggctgtt tcaagcgtac acatgaagaa tgaagtgtac gagaaaatac 582421 aaagtcacga tatcggcaaa ggagatgtac tggctgtcgc acaggtggca ggcattatgg 582481 ccgcaaagca aacgtcgaat atcattccga tgtgccatcc gctttcattg agcggggtag 582541 atatatcgtt tgactggaaa ataaaagaag cagaagttat acttcatata aaagcacagg 582601 tcaaaacgaa agggagtaca ggtgtggaaa tggaagcgct cacttctgca tcggtgtgcg 582661 ctcttaccgt ttacgatatg tgcaaggccc ttgataaggg aatggtcatc ggccctactt 582721 tcttgctgga gaagacaggc gggaaaaacg gtgactttaa aagagaacta tccgagtata 582781 atttggagga ccaaaaatga ataaggatca atcaaaaatt ccgcaggcga cggcgaaacg 582841 gctgccgctt tactatcgct ttttaaagaa tctgcatgcg tcaggaaaac agcgtgtatc 582901 atccgctgaa ctcagtgatg ccgtaaaggt tgattctgcc acgattcgga gggatttttc 582961 ctattttgga gctcttggca aaaaaggata cggatataat gtggattatt tgctgtcttt 583021 tttccggaaa acgcttgatc aggatgagat gacagacgtc atcttgattg gtgtcgggaa 583081 cttgggaacg gcatttcttc actataattt cacaaaaaac aataacacaa aaatttctat 583141 ggcttttgat ataaatgaga gtaaaatagg aactgaggta ggcggcgtgc ccgtctataa 583201 ccttgatgac cttgaacaac acgtaaaaga tgaatcagtt gccattctta cagtgccagc 583261 agttgccgct caatccatta cagacagatt ggtcgcatta ggaatcaagg gaatccttaa 583321 ttttacgccg gcccgtttga atgtgccgga acacattcga attcatcata tagatttagc 583381 agttgagctt cagtcactgg tttatttttt gaagcattat tcagttttag aggaaatcga 583441 atagagggaa aggaggagcc caaatatgcc gatcggtcct ggaagccttg ctgttatcgc 583501 aatcgttgct ctgattatct tcggtcccaa aaagctgcct gaattgggga aagcagcggg 583561 agacacactt cgtgaattta aaaacgctac taaaggatta acgagtgatg aagaggaaaa 583621 aaagaaagaa gatcagtaag ttaggatgac acgaatgaaa gtgaatcaaa tgtcgctgct 583681 ggagcatatt gctgagcttc gaaaacggtt gctgattgta gcgctggcgt ttgtcgtttt 583741 ctttattgct ggattttttt tagcaaagcc gattattgtg tatctgcaag aaacagatga 583801 agcgaagcag cttacgctta acgcgtttaa cctgacagac ccgctttatg tgtttatgca 583861 atttgcgttt atcatcggca tagtcttgac ctcgccggtt attctttatc agctttgggc 583921 ttttgtgagc ccgggcctct atgagaaaga gcgcaaagta acgctcagct acattccggt 583981 ctctattttg ctgtttttag cgggcttatc tttttcatat tatattttat ttccttttgt 584041 tgttgatttt atgaagcgga tttctcagga cttgaatgtc aatcaggtga tcggaattaa 584101 tgaatatttt cattttcttc tgcagctgac gattccgttt ggactgctgt tccaaatgcc 584161 ggtcatcctc atgtttttga caaggctcgg aattgtgaca ccgatgttct tggcgaaaat 584221 cagaaagtat gcgtatttta cgctgctggt gatcgcagcc ctgattacac cgcctgagct 584281 tctgtcccat atgatggtca cagtcccgct tttgatttta tatgaaatca gtatccttat 584341 atcgaaggcc gcttatcgga aagcacagaa aagcagtgct gccgatcggg acgtgtcttc 584401 tgggcaataa taaaaaatcc atttctcatg cgagaaatgg attttcttta tttttggttc 584461 tttttgattt taaatgaaaa ggcgaacatc ttaaaagaaa tgctgatgtt gtaagcggcg 584521 aacaccatca gcaggatgga gtaaaatgac cacatgctgc ctggcgagct tgcggcaaga 584581 taagtaaaga tgcaccctac ggcaaagtag atcattcccc aaactaccgg gtttctcata 584641 aaaataatcc tccaataatc aattgcattt gtgtgctctg ctgttcaagg taattacgaa 584701 caggctcaag ctgcatgatg acgacgaatg tattcatcat taaatgggcg aaaatcggca 584761 cccatatccg ttttgttctc gcatataaaa aggcaaaggt aaagcccatt gctgtatata 584821 gaaggagatg cttcaaatca gcgtgaacaa taccgaagat aaccgagctg atcagtcctg 584881 cgaaaaagaa attcgttttt tcgtacagcg cgccgaaaat gatttttctg aagatgattt 584941 cttctaatat aggcccgacg atggaagaaa cgataatcat gagcgggact gcctgaatga 585001 catccagaat cgcttgtgta ttttctgatt ctcttccgat gccaaaaaca taatattcaa 585061 tagagcctgc tattccttga gagaaaaggg caatgaaaaa accggctatc gcccaaagga 585121 tagaaagtcc gattgagtcc ttctgtccgt ttcgcagcgt ttctttcgga acggttctca 585181 gaatgagcag aacaacaacg agacaggcga taaagctgat aacggaccat aatccttgtg 585241 catgcagcat attttcatct gtaggctgtc ctccggcata accgaattta aataacaagg 585301 gaatcgcgat taatgcggaa aactgcatga tgatatatgt caaaataata aaccaatact 585361 gttttctcaa atggtatgta ctcctttgtt aagtgggttt cgttcatcta cagctattgt 585421 aacataatcg gtacgggggt gaaaaagcta acggaaaagg gagcggaaaa gaatgatgta 585481 agcgtgaaaa attttttatc ttatcacttg aaattggaag ggagattctt tattataaga 585541 attgtgttag cactctttag tgctgagtgc taaaattaca tattcatact attgaggagg 585601 ttatttcatt gttaaagcca ttaggtgatc gcgttgtcat tgaactcgta gaatctgaag 585661 aaaaaactgc cagcggaatt gtgttgccgg attctgcaaa agaaaaaccg caagaaggca 585721 aaatcgtggc agctggttca ggtcgcgtgt tagaaagcgg agagcgcgtt gctttagaag 585781 taaaagaggg cgaccgcatt atcttctcaa aatacgcagg tactgaagtg aaatacgaag 585841 gtactgaata cttaatctta cgtgaaagcg acattttagc tgttatcggc taattcttaa 585901 ataaacaata cttaaaacat ttgaggaggt cttgtaaaca tggcaaaaga aattaagttt 585961 agtgaagaag ctcgccgcgc aatgcttcgc ggtgtcgatg cacttgctga tgctgttaaa 586021 gtaactttag gaccaaaagg acgcaacgtg gttctagaga aaaaattcgg ttctccgtta 586081 atcacaaatg acggtgtaac aatcgctaaa gaaatcgagc tagaagacgc gtttgaaaac 586141 atgggtgcta agcttgttgc tgaagtagcc agcaaaacaa acgacgttgc cggtgacggt 586201 acaacaactg caacagttct tgcgcaagca atgatccgtg aaggccttaa aaacgtaaca 586261 gcaggcgcta accctgtagg cgtgcgtaaa gggatggaac aagctgtagc ggttgcgatc 586321 gaaaacttaa aagaaatttc taagccaatc gaaggcaaag agtctatcgc tcaggttgct 586381 gcgatctctg ctgctgatga ggaagtcgga agccttatcg ctgaagcaat ggagcgcgta 586441 ggaaacgacg gcgttatcac aatcgaagag tctaaaggct tcacaactga gcttgaagtt 586501 gttgaaggta tgcaattcga ccgcggatat gcgtctcctt acatggtaac tgactctgat 586561 aagatggaag cggttcttga caatccttac atcttaatca cagacaaaaa aatcacaaac 586621 attcaagaaa tccttcctgt gcttgagcag gttgttcagc aaggcaaacc attgcttctg 586681 atcgctgagg atgttgaagg cgaagcactt gctacacttg ttgtgaacaa acttcgcggc 586741 acattcaacg cagtggctgt taaagctcct ggtttcggtg atcgccgtaa agcaatgctt 586801 gaagacatcg ctgtccttac tggcggagaa gtcatcacag aagatcttgg ccttgacctg 586861 aaatctactc aaatcgctca attgggacgc gcttctaaag ttgtcgttac taaagaaaac 586921 acaacaatcg ttgaaggcgc tggcgaaaca gacaaaattt ctgcccgtgt gactcaaatc 586981 cgcgctcaag tggaagaaac aacttctgaa ttcgacagag aaaaattaca agagcgtctt 587041 gctaaacttg ctggcggcgt agctgtcatc aaagtcggcg ctgcgactga aactgagctg 587101 aaagagcgta aacttcgcat cgaagacgcc ttgaactcaa ctcgcgcagc tgttgaagaa 587161 ggcatcgtat ccggtggtgg tacagcgctt gtaaacgtat ataacaaagt cgctgcagtt 587221 gaagctgaag gcgatgctca aacaggtatc aacatcgtgc ttcgcgcgct tgaagagcca 587281 atccgtcaaa tcgcacacaa cgctggcctt gaaggatctg tcatcgttga gcgcctcaaa 587341 aacgaagaaa tcggcgtagg cttcaacgct gcaactggcg aatgggtaaa catgatcgaa 587401 aaaggtatcg ttgacccaac aaaagttaca cgctcagctc ttcaaaacgc tgcgtctgta 587461 gctgcaatgt tcttaacaac agaagctgtt gtcgctgaca agccagaaga aaacggtggc 587521 ggcgcaggaa tgcctgatat gggcggcatg ggcggtatgg gtggaatgat gtaataaagg 587581 gatattaacc cttatacatc aatgttttaa ccgtcttaaa aaactagaca aagcgtgaat 587641 aaaaaaagag aaggtctttc atcagtttac taaactgttg ggagaccttt tctccatatt 587701 agcggtcata tgagcataaa tgtccatcgt cgtatttatg tccgaatgac caaattgttg 587761 ctggatttct ttaatgccta ctcctgcctc aattagtaag gaggtatggg tatgcctaaa 587821 agagtggggg gtgacattct ttttatccca gcttttttga gcagccgttt aagtctagtc 587881 tcaataacct ttcttaattg cggatgacca tcctcccgct caaaaataaa tgatgagtct 587941 tgataaatca atctattttt aagcttaatt tcattttgat aaattttatt tttttttagt 588001 agattgacat cgtttcatca attcgaacga tatcaacaga tcctgttgtt ttaggtgtta 588061 gcaattggta tttttcaatt tgattgttag gggtgtatag ggtctttgtg acctggctta 588121 tcattgaaat ctgtccattt taaagcaaga agttcaccaa ttcttaggtc ggtctaggca 588181 agtacggtaa agaccaaatg gtccatttct agcccgtcag attgagcgag ctttagaaaa 588241 tgtgtcagca cctctttttc caatgctttg ttgcttcttg ggtaattgaa aatccccagt 588301 tgggttcatt ttaataatcc cttgagtttt agcttttcgg aaaatcatac ggccgcaggc 588361 atgaatacct cccaaacaat tgtgactgta ttgctcgttc agttctaacg tgcggtcttc 588421 atacattttt ttgtgttttg ctaatcgggt attgacccaa tactgcgata aaatgcatca 588481 ttttcttttc actggcccgt acactgctta tttttacccc actccggttg taaatcttaa 588541 gccaaccttt tgcaaatgtt ttgaagggca tatctgactc cttaataaaa gtcccgttgt 588601 cgttttggag ttctacgtga cgggctgcta ctggggcttc tttctttgtt ttaaatcttc 588661 ctttggatat ttctagacgt tttttggtta aagggtcaat gcctagtaga tatgataact 588721 ccacgtctta ccgcattgct tgagttttgc catttatttg tccctaacta attttttttc 588781 atcaaattgg tctttaagtg agtttaataa tttttgtttc tctcgactgg tcaataattg 588841 cccttcatat ttcaaaagat tggataaatt tgagatggaa tcaatcctga tggatggtac 588901 cgtagacttt aataagaaac gaaaggccaa ctgcgacttc agttggcctt tcctatttat 588961 aataaagaaa ttgagtgaga ttgctgacag aactacgtac tactcgtttt ctttagttgc 589021 ccttgctaat cgttcaacct ctccccgaat cccaatcgca ggctcccacg aatcaatcaa 589081 acgaatcgcc ttctgattag attccaccgc tttcgttttc tctcctttac gatacaacag 589141 ctgcgccatt ccgtagtgat agtagatcag ttcaacttga ttggcgttat gtttgtcata 589201 gagcatttgc tcaaaggctt cttccgcttt ttcaaactga tcacatttca cgtaagcgac 589261 acccagattg aaataggctt ctatcgtttt ttcgccgccg tatgtggagc tgatttcatt 589321 tgccgcttcg tataattgaa tggcttctac atgataacct ctcgcaaagc ttaagtcacc 589381 gcgaaccaat agaactctgt gttgaatggt aggggaaatc ggttgatttt cgatttcgtt 589441 taaaattgtc tctgcttttt cctgttgccc gtcttttaaa aacagccttg ctttgagtgc 589501 atgtccccaa acctttagat cataggcatc gtgagcgtct gattgttcaa gaatcttcag 589561 cccggcttct atttgctgaa gcgctccgtc taaatcattg acttccatca atgcccagcc 589621 tgaggtgtcg attcggaagt acgcttctcg tgtgtgttgg cctaagtgat gggcggcgtc 589681 ggccgctttg cgtccgtatt cgattcgcag gggcaggttg attctgctta gaaaatggct 589741 aatgcgggtg atgagttcga ttaggatttc tttttgttca gtttcacttg cccattggat 589801 gacctttaag atgtttggcc attcttgttt catttgatct aagttccgtc ccagcaggta 589861 gctccaatag atagagttgg gctgttcccg ctttaaatgg gtttcggcat aatcaatata 589921 atagtgcgcc cagcgattgc gggcttcttt ttcatattcg tgctgttcgg acaagtgctg 589981 ttctccgtaa gcgacaacgg tttggtgcgc taagtattgt gtcctgcctt ggcttcgttc 590041 cggctgaatc agcgcatatg accgcatttg ttccatagcg taatgaaaac ggcgggcgtc 590101 taatccggct gctgccgcca ggcttttttc atcaggcggc ttgctgaaaa agcaaagcgt 590161 ctgccagagc tttcgcgtat cttcattgca tctatcccag gtgcggccaa agaggaattc 590221 aaacaattcc agcagtgagt agcctgcttt tccaagctca tgaatcagct gctgagcggg 590281 gatgtcatcg tctgacatat aggcaatgct gagtgccatg gctttcgggt ttccggcagt 590341 cgctgaaatg aattcgtttt tcaggtcaga tgatagatgt aacagctgct ccagcttttc 590401 ccgtttacgt gggaggttgc atgtttgtaa gcagtgatgc acttcttgtt gaaaaaattc 590461 gtgggcatct gtttggtcaa gaccgcttag ctgaatggct gtcatttctc cgaagctttc 590521 ccgataagtt tgctttacgt tttcccgcgc tgtaaggaga acttttacgc cttgcggaag 590581 gctggtgata aattcatgaa tgtcacgttc tgcagtatca atgctgtcaa cgatcagcag 590641 gatcggtttt tctctagtgt aattggctaa cgcattgcgg acgacaaacc gttttacatt 590701 gattgattta tcgatttgtt ctttgcgtcc gagctgatag gcgatcgtat ttaaaaaatc 590761 gctaaagctt aatcctttcc aatcagcgct gacccagatg atgctgttga atgccggcca 590821 aactgaagta tcgtcgacac aggaataggc ggcttcaaga gcaattgtgg tttttcccat 590881 gccggcccag ccggtgatta aacagactgg tgatggagaa agcatccatt gccgtatcgc 590941 ttccatatca aagctgcgtc cgataaagcg tccggaccag cgtgagggta aattatgcgt 591001 gatgggctgt tctgtaagcg cattcgtttc ttggccgggt ctgtcatgaa acagccgttt 591061 tactacattt tcaatttcgc cttcactcgg agccccgaat aatccgtctt ttcgcagtat 591121 tttcgctttt ttcaaacagg atgctgccca tacaggcaat gcgggtttga tgactgggat 591181 agtggtggct tccagcaagt cggtcaacca ctcgatatcc aagtcggtct tttcgagaat 591241 gatccagatc attccgaaca gttttccgtc gtcgattctt ccgggaatgt agtttgcccc 591301 catctgtccg atccagcttt tgatcgtgtt tggggagact cccagctgga gtgcgatttt 591361 atctatgtaa gactgtcctg ttttttcatt ctttttcctt ctgactttat aatcaggatg 591421 aagttttagc gttttgacgc caggtgccag catttgtgca aattgttttc ggttttcaag 591481 ttcagccata agcctgcacc tcctattagt actattttat caatccagcg ttttttgtat 591541 atgaaaaaat aaaagtacag tgccgctgtc cttttataca gcaggaaagg ctgttgaacg 591601 tgttaaaaag cagataaaat gggggcagta acagagaaaa caaaaatgta tgcacttaca 591661 ttttattttc taaagaaagg aacttgccaa atgactcaca cagtacctca aaacatgaaa 591721 gcggctgtta tgcacaacac aagagagatc aaaattgaaa cattgcctgt gcctgatatc 591781 aatcatgatg aagtgttgat taaggtgatg gctgtcggaa tttgcggatc tgatctgcat 591841 tactatacaa atggccgaat aggcaactat gttgtggaaa aaccatttat ccttgggcat 591901 gaatgtgcgg gtgaaattgc cgctgtcgga tcatctgtcg atcaattcaa ggtgggagac 591961 cgcgtcgctg tagagccggg tgttacgtgc ggacgctgtg aggcgtgcaa agaaggacgc 592021 tataatcttt gcccggatgt acagtttttg gctacaccgc cggtagacgg tgcgtttgtc 592081 caatatatta aaatgcgtca ggactttgtt tttttaatcc cagactcact ttcttatgaa 592141 gaagctgctt tgatcgagcc gttttctgtc ggtatccatg cggcggccag aacgaagcta 592201 cagcccggat caacgattgc gattatgggg atgggccctg ttgggttaat ggctgttgcc 592261 gcagctaaag catttggggc aggcacaatc attgtcaccg acttagagcc gctgcggtta 592321 gaagctgcga aaaaaatggg agcgactcac attattaata tacgtgaaca ggatgcactt 592381 gaagagatta aaacgatcac gaatgataga ggcgttgatg ttgcttggga aacagcaggg 592441 aatccagcgg cattgcaatc cgcactggct tctgtgcgcc ggggcggaaa attggcgatt 592501 gtcggtttgc cttcacagaa cgagattccg ctcaacgtgc cgtttattgc ggataatgag 592561 attgatattt acgggatctt ccgttatgcc aatacgtatc caaagggaat cgaatttctt 592621 gcttcaggca ttgtggacac gaagcatcta gtaacggacc aatattcgct ggagcagacg 592681 caagatgcga tggagcgggc gcttcaattt aagaatgaat gtttaaaagt gatggtgtat 592741 ccaaatcgct gagtgaacag ggaggatctt cgtattctcc ctcttgttta ctggaaatga 592801 aaacggattc ttggggtggg aaatgatgat tggaacagaa aaagtaacgg cattgaaggc 592861 gaagcatcag tcaaaatcca gcaccggcct gtcctggttt gaacgaatcg gttatggatt 592921 cggcgatatg tcgtataata ttatctttca gtttgtaaac gcatacttat tattttatta 592981 tacagacgtc ggcggcattc agcctgcggt aatcgcaact ttgtttcttg ttgtgcgtgt 593041 gctggatgct atttttgacc cgatcatggg attgatttta gataaaacga atacaaggtg 593101 gggaaaagca aggccatatt tgctgtgggt ggcatttcct tttgcgctat tcacattctt 593161 atgtttcacg acgcctcatt tcggtgagac cggaaatatg gtatatgcgt atgtcactta 593221 tattctgctt gggatgtcct ttagtatgca aacgatcccg gtgaacagct taacggggcg 593281 gatgacgaat tcggtggagg aacgaacggt tctgaccaca acccggatga ttttggtgta 593341 tatcggcatt cttttatcca tttcctgtgc gacaccgctt gcaactgcta tcggaggaga 593401 ggatcaggcg tttggatttc agatgacggc gctcatctat gcggctgtca gcatcgtttt 593461 gaatctattt agtttcttta ctgtacggga gcggattcag cctaaaaaga gaaaaaaaca 593521 agggatcaaa aagacgttat ccgttttatt caaaaacaaa cccttgctca tgttaatttc 593581 atcatttttg gcttttgcga tcgggtttaa tattaagctc agcacgatgg tgtattattt 593641 tacgtataac gtaaaccata aagagttcgt gtttatgggc accgttttat ttttcggggc 593701 agcgctgatc agcaatttgt ttattccttt cttttctgag aagtggggca gaaaacaagt 593761 catgattatc acggcagctc tatcgcttat ttcttatgcc ggcctgcatt ttacgccgta 593821 ttcttcaatt ccactcattt tcatttggct tttcgcttcg ggatttttca caacgccttt 593881 aaatacgctt gcttggggaa tggttgcgga ttgcgtcgat tatgcggaat ggaaaaccgg 593941 aattcgcgcg gatggtgttg tgatttcgag catgagcttt attaataagc tgggtgttgc 594001 gttagccggg tcattttcgg ccatttattt aggaatcgcc gggtatgtgg cgaatacaga 594061 ccagacagtt gcgtcgttga atgcgattaa aaatatgaat gctttgattc cgggattttt 594121 cattttgctt tctattattc ttatcgcctt ctatccttta acggaaaaaa gatataaaca 594181 catcatctct gagctggagc aaaggtctgc gagataaata gatgtaaaat ttttaatatt 594241 caatgttgta tttatggcaa aaagtaatat actgagactg taatctagac tttataaatg 594301 agtgtgataa tatgcgtagt cattctgtag tttgtattgg ggaattgttg attgatttct 594361 tttgtaccga tgttgacgtt gatttaatgg aagggcgcca attcctgaaa agtgccggcg 594421 gggcaccggc gaatgtgtcg gcagcgattg ccaagctggg cggagacgcc gctttcagcg 594481 gaaaagtagg aaaggatccg tttgggtatt ttctgaagcg aacattggac gctgtacatg 594541 tcgatacctc tatgctggtg atggatgaga aagcgcctac aacgcttgct tttgtttcat 594601 taaaacaaaa tggagagcgt gactttgttt ttaatagagg cgcggacgct ttgtttacgc 594661 tggaggacat tgaccaggaa aaactaaacg aagcgaaaat ccttcatttc ggctctgcga 594721 cggcactgtt atcggatccg ttttgctcag cctatttacg gttgatgtcg attgcgaaag 594781 acaatggaca gtttatttcg tttgacccta actaccgtga agatttatgg aggggaagag 594841 tctcagagtt tgtaagtgtt gcgaaaaaag cgatcgctgt aagtgatttt gtgaaagtca 594901 gtgacgagga acttgagatt atcagcggtg tgaaggatca tgaaaaggga gttgcgatcc 594961 ttcatgagat cggagccaac attgtcgctg tgacacttgg gaaaagcgga acgcttcttt 595021 ccaatggaaa agaccgtgaa atcattccaa gcattccggt gacatcaatt gactcaacag 595081 gggcgggaga tgcttttgtc ggtgcggctt tatatcaatt ggcaaacacg gatcagattc 595141 aatctgtaga tgctgatttt gtgaaactgc gtgagattgt ggcgtttgcc aataaggtcg 595201 gagctcttgt gtgcactaaa attggagcga ttgatgcact gccgagtttg gatgagattg 595261 gagtttcttt gtaaatcatt gaagatgttt cttgaaagtc tttggacttt tgggggcatc 595321 tttttttatt gcttacattt ttgttcaggt aaaaagttgt atattttttg tttgaaatgt 595381 cattttttat taaaaaagtg aaacttttaa cgataataaa tagtatatgt aacaagggtt 595441 accgaattag ctttaggagg aacgatataa tgagtataat tggaagattt aaagatatta 595501 tgtctgcgaa tatcaatgct ttattggaca aggctgaaaa tccggagaaa atggtagatc 595561 aatatttaag aaatatgaat agcgatttgg ctaaggttaa ggcagaaaca gcagctgtta 595621 tggctgagga gcagagagca aaaagagaat atcacgaatg ccaggcggat atggaaaaga 595681 tggaaagcta tgcaatgaag gcgctgcaag ccgggaatga gagcgatgcg agaaaatttc 595741 ttgaaagaaa aacatctttg gagtcaaagc tttctgagct gcaggcggcg aatcaaattg 595801 ctgcaaccaa tgccgcacag atgagaaaga tgcatgacaa attggtatct gacattggag 595861 agctggaagc acgcaaaaat atgatcaagg cgaagtgggc agtagcgaaa acgcaagaaa 595921 gaatgaacaa actgggcgct tctgtttcaa gtacaagcca atcaatgtct gcattcggcc 595981 gaatggagga caaagtaaat aaggcacttg atcaggccaa tgcaatggct gaactgaaca 596041 gcgctccgca ggatgatatg gctgatctgt ctgcaaagta tgacactggc ggttcaagcc 596101 aggttgatga tgaacttgcg gcgttaaaag cgaaaatgat gctcgataag taatacatag 596161 gaggccgcag ctttcggctg cggcgtcatt ttatcataaa atgtgagagg gaacggtaat 596221 gataatatct tataagtgtc cgaactgcgg cagtgatatg gcatttgaca gtgaaaccgg 596281 ctcgttatcc tgcagcagct gcggaagaca ggacaatatt gaaagccttc cgaaagaaaa 596341 cattgcggca cggttttctg atgatgaagc aaaagaatat caatgtaaaa actgcggtgc 596401 cgttttgatc acggaagctg aaacgacagc aacgacgtgc agcttctgcg gaggtgctgc 596461 aatacttgcc gatcgtttat caggacattt ggcgccggcg aaggtcattc catttacaat 596521 cagcaagcaa gaagcggagc aggcatttcg aaagtggtgc aaaaaaggcc ttctgacacc 596581 aagaggtttc atgtctgctg atcgtatcaa aagcatcacc ggcatgtata ttccattttg 596641 gatgtttgat ttaaatagtg aagtacaggt gagagcaaac tgtaccagag tccatcaata 596701 tgaagaaggg gattatattt gcacggaaac agagcacttt gaagcgtttc gtgatatcaa 596761 tctcgattat ttgaaaatcc ctgtcgatgc ctctgaaaaa atgaaagacg aattaatgga 596821 caaattggag ccttattcat acgaagagct gaaggacttt caaacggcat atttggccgg 596881 ttatattgcg gaaaagtaca attataccga tgaggagctt tttccgaggg caaaagagaa 596941 aatcagcagt tatatagatt catacatcca ttctactttt tccggatata cgtcagtcaa 597001 tgtgagggac aaacatattc acacgaaaaa cgtgaacagc ttttacgttt tgcttcctgt 597061 ttggatggtc agttacgatt atgaaagagc ggagcatatc tttgcgatga acgggcaaac 597121 aggaaaggtc gttggaaagc cgccgatcag tcgaggaaaa gtggctgcat ggtttagcgg 597181 aatagcaggc gggacatttc ttgcgttgaa gctcgtctca ttgatgatgg gaggcggatt 597241 ttgatgcgtg gattttttgg gaaagcgatc tttgttgtgc tggctgtttt catcatgatg 597301 cctttactgg gtatcgaagc ggtaagagcc tctgaattgc agcagcatgt gtacgatcgc 597361 gctcatctat tgtcaaaagc ggagatcgga aaacttgaat ctctctcggc aaagctgggt 597421 gcaaagaggg acactgattt catcattatt acgaccaaaa gcacaaacgg tgaagatatt 597481 gcagactata ccggcgattt ttatgatcgt tacggaaaag gcagtacagc cattctgacg 597541 attgatatga caaacagaga agtgtttatc gcaggcttta aaaaagccga acagtatttg 597601 gacaacagca ggctcaatag catcagaaat acgatttcat ctgatttatc caatgaaaat 597661 tattttgaag cttttgagac atatattcag ctttcctata aagatatggg cataaaaccg 597721 ggagtaaacc ctgacaacat attctttaca tggtggtttc agctgattgc tgccatcgca 597781 gtcgggggaa ttgcggtttc aatcatgctt tatcatgcag gcggcaaagt aacggttaat 597841 ggaagtacat atatggatca gcgtacgtct gatgtgattg atcaatacga cacttatatt 597901 agaacgactg taacaagaga aagaaaacca tcagataaag acagcggcag cgatggcggt 597961 gttacgaaag gcggcacgtc atacagtggg agccggggca gtttttaaat gtaagaaata 598021 gagaaaggga gaggcgtaat gtcgtttttc agaaatcaat tagcgaatgt agtagagtgg 598081 gaagaattta gagatgatat gattttttat aaatggaaca atcgtgaaat caaaaaaggg 598141 agccgtttaa tcattcgtcc cggacaggat gctgtctttt tgaacaatgg gcgggttgaa 598201 ggagtctttc aagatgatgg cgattatgat attgaatcag aaattattcc attcctttca 598261 acgttaaagg gctttaagtt tggctttaac agcggcatgc gagctgaggt gctgtttgtc 598321 aatacgaagg aatttaccgt aagatgggga acaaaacagg cgataaatat tccggcagcg 598381 ggaatgccag gcgggatgcc cattcgcgca aacggcacat ttaatttcaa ggtgcaggac 598441 tatatcagcc tgattgataa aatcgctggc gtgaaagatc aatattttgt agaggatatt 598501 aaaacccgta tcatttctat tctggatcag cttctcatga agtggatcac aagagaaggg 598561 aaagatatgt ttaatcttca agcaaacgct tttgatattg ccaagggaat tcaagaggac 598621 ttagatatgc aattaataag cgacgggatg acggtcactg gttttcaaat catgagcttt 598681 aattatcctc aagaggttca agatatgatt acaaagaacg cttcctacgg tatggttggg 598741 gatgtgaaca gataccagca aatatcaatg acggatggaa tggcatccgg aaagatgagc 598801 ggaagcggag cggcttcgga tatggctgga atgatgatgg gaatgaatat ggccaatcag 598861 atgatgaacc aaatgaatca gaatcagcag gcacagtcat caggcccaca gtcaactggc 598921 agcggaagca aaccgaattt ctgtccaaac tgcggaacaa aaacgggcga agccaatttt 598981 tgtccgaatt gcggccagaa gcttgtataa gaatcataca gtgaaaagtc cggagtgatc 599041 agcactcggg acttttttat ttaggagaat aagcattacc tattgcttgc tcctgaacag 599101 gccattttcg agcccccgct tggataattc ccagcagcaa ttgacgacgt tcctttattg 599161 aattgacggc aatttgaaat gtttgctttg ataaagccgg tatgcctgat tgttgaagct 599221 ttgagatgtc tggttctggc ggcgcttgtt ctgcaggatg gatataggca gtatgaacgg 599281 tatccagata gtttttgata cttgagcgcg cttctttgat atgaagctga ttcggctgat 599341 attgttcagg aattccgtat ttgaaaatgg ttagagcctc atccaataca gcaacagcta 599401 taatggatga ttcctgatgc tgcgtgctgt ggtaaaaatg aaggatgggg aaggcgttat 599461 gctgagcggt cagctttccc agttctgatg aggcagcgac aagaagaaaa tcaatgtcgt 599521 gaaaatcttt gccattccat gcattatgga cgatttcagt tccgtcatgc cctagactta 599581 atacactttg ggcaaaggag cgtttttgat taaccgcact caagacggaa atcaaatacg 599641 tgacagaaaa tgtgatggta agcagtcctt gagctgtttc aataatcgtg acaagcttcc 599701 ataggcctcc gttcggagcg aggtcgccat ttcctaatgt aaacatgaca tagccggaaa 599761 aataaattcg gtctgaccag gaagccggtt cttttgattg agtttccata agtgagtgag 599821 ggtcactcga gtaaatcaaa acccacccgc tccaaaatag actgatccat atcactaacg 599881 tcaggcataa cagcagagga ccagccatac ttagaacctt tgcgtggtca ccgctgattt 599941 tgcggcagcc cttccacagc caggcagaca ggcatcttgt gatcgggccg gcaccgctct 600001 ctaaccataa cgtggtccat aaaaaatcaa tcatccccgc tgtcaataat aaaaggcctg 600061 caatgatata accctcattc attttggttg cctcccttaa gtcagccttc ttttattttc 600121 ttctctattt ccttttatcc tgagtctgaa acaattgaac gaatgtttga ttttacagag 600181 aaaaataggt gggagttacc caacacttac tcatttttca atatgaacag aaaatcacaa 600241 gatttttgac ttgattcaca cattttcatg aagaaaaacg ttcattttcc ccttgaattg 600301 gtgattttcc ttttatagag taaaaaattt tcagaaattt atattgactg aaagcgtttt 600361 tataattatg ataatatcag atataacaaa aatgtcacta taacatcact acaattgaac 600421 tattaagtga ctaataaata ccaaatgaac gaggttatgc acaaagaaat gaccattgtt 600481 cttttaacga gaaatgaaat cgcttccata gggattgaca tgctaagaag aagggaaggt 600541 tatgaggtta ttggataaaa acatgaacaa ctattttctg aagcctgctt acgaaatgtg 600601 aggaaggcag cagccctgga ataagttttt gacatacgca ttttgaaaaa gactggggga 600661 aacagtatga ataaacaagg aaatcaaatg tcatttttac gtacaattat tttagtctcc 600721 actttcggcg ggcttctttt tggctatgat accggtgtgc tcaatggagc tttgccgtat 600781 atgggagagc cggatcagct taatctcaat gccttcacag aaggccttgt caccagttca 600841 cttctttttg gagcggcact gggtgctgtg tttggcggca ggatgtctga ttttaacggc 600901 cgccgcaaaa atattttgtt cctcgctgtt atatttttta tttcaacgat tgggtgtacg 600961 tttgcaccaa atgttacggt catgattatt tcccgttttg tgctcggtat tgcggttggg 601021 ggtgcatccg taacggtgcc tgcctattta gcagagatgt ctcctgtgga aagcagggga 601081 cggatggtga cgcagaacga attgatgatt gtatcaggac agcttttggc ctttgttttt 601141 aatgcgatcc ttggaacaac aatgggagac aactcccatg tgtggaggtt tatgctggtc 601201 attgcgtcac ttccagcctt gttcctgttt ttcggcatga tcagaatgcc cgagagtccc 601261 cgttggcttg tttctaaagg aagaaaagaa gatgctttgc gtgtattgaa aaaaatcagg 601321 gacgaaaaac gggcagcagc tgagctgcaa gaaattgaat tcgctttcaa aaaagaagac 601381 cagcttgaaa aagcgacatt taaagatctt tcagtcccat gggtgcgccg tattgtgttt 601441 attggattag ggattgcgat tgtacagcaa attacaggtg tgaattcgat tatgtattat 601501 gggactgaaa ttctaagaaa ttccggtttc caaacggaag ccgctttaat cggaaatatt 601561 gcgaatggcg tgatttcggt attggcaaca ttcgtcggaa tctggctgct gggaagagtg 601621 gggcgccggc cgatgctgat gacaggcttg atcggtacga caacagcatt attgctaatc 601681 gggatattct cacttgtact tgaaggatca ccggcacttc cgtatgtagt cctgtcatta 601741 acggtcacat ttcttgcttt tcagcagggc gccatttcac cagtgacttg gctgatgcta 601801 tctgaaattt tcccgcttcg ccttcgcgga ctgggaatgg gtgttacggt attctgtctg 601861 tggatggtga attttgcagt cagtttcacg tttccgatat tgctggcagc tatcgggctg 601921 tccacaacgt tctttatctt cgttggatta ggaatttgct ctgtcttgtt tgtgaagagg 601981 tttttgccgg aaacgaaagg gctttcgctt gagcagctgg aggaaaactt ccgcgcttat 602041 gatcacagcg gggcaaagaa ggattctggg gctgaagtga ttggataatt taaaaaagaa 602101 tccgcacccg agtgcggatt ctttttggtt tcaaattagt taggtctaac aaggattttg 602161 acttggcttt tctctttaat aagagccccg aagccttcct cgatcaaatc atctagtacg 602221 atttttttcg ttacgagttt gtcggctgag aaatagcctt ctttcattaa tgacaataca 602281 gccgggaaga tgtcgcggta tccgataatt ccttttactg tacgttcttt gattacgata 602341 tcgttcggat ggatttcagc acctttttcc caaatgctga cgatgacggt ttcaccggca 602401 attgtagtgg actggatggc ttgtcgtaac accactggga caccagtgac ttcgaatgct 602461 acgtcaacac cgcctcctgt acgttctgca atctcagcga ctacatcgtc tgttttagac 602521 ggatcaacga tgatcgcgcc aagctcctca gctttttgct ggcgttcagg agaaagctca 602581 acagcgtaaa tatcagttgc accggcagcc ttcagcgctt caatgacaag aagtccgatc 602641 gggccgcagc cgaatacagc cgctttgtcg cctgctttga gtttgcttga gcggacagcg 602701 tatagagcaa ctgcagaagg ttcaacgagc gcgccttgtt catatgataa ttcatcagga 602761 agtttgaaca aaagctcttc atccacagag acgtattcag agaaaccgcc gcctccgccg 602821 gctaagccga ggaatcccat ttgttcatca aggttgtagg cgccttggtg gccgtgtgta 602881 gcaaaaatcg gctcgactac aacgcggtct ccaactttat aattttcaac gccttctccg 602941 acttcgacaa cttcaccgga gaattcatgc cccattgtga caggtgccgt ttcatttgtt 603001 aatgggtgcg gtttgtcaac cggaataaag atcgggccgc ccagatattc gtgtaaatca 603061 cttccgcaga tgccgcacca tttgactttg atctttactt ttcccggctc cgtttttggc 603121 tcttcgatat gttcaatacg gatatccttt tggttatgcc atcttgctgc cttcatggat 603181 taccactcct ataacttttg atgtgagtaa ttccgcaccg gtcaatatga actgttcaca 603241 aaatcgccat ttttaaaacc aaaaaagaaa tgaaattttt atataatata atctacgttt 603301 ttttgaaaaa aagaaacttt aaagaaaaaa gggtctcgca cactcttttt tctttatatg 603361 agagtatcaa tcgtttacat agctatgaat ttggtttgaa caatacggta atggttcgtt 603421 catattgaat gcgacaacta ctctatcaat aattataact ctaatactgc tattataata 603481 ggataatctt ccatggttta ttttagcaga ggtaactttt ttgactttgt aacattactg 603541 taaggatatt gaaataaaaa atagctggtt gatcgtgtat aatcttccta gatgttaaca 603601 aacaggggga cgaaatgttg aagaaagtca ttttagccgc ttttatctta gtaggaagta 603661 ctttgggagc ttttagtttt tcatcagatg ccagtgcgaa acatgtgaac ggaaatatta 603721 cttggtataa tggagtcggg aaaaaaggct cttcaggtaa gaaacttgga cattgggatt 603781 gtgcgaccaa aatcggattt gatgttccta gaaacgggac aaaaatcaga gcttatgcaa 603841 aagcgaagcc taaaaaggtg attacggttt ataaaaatga tgttggcaga atgcctaatg 603901 cagtgctgga tgttagccct aaagcgttta aagcgcttgg atacccatta agcaaaggta 603961 aagtagcggg gcattacagc tattaatgta catatataat ctggaaagca agaagtcaca 604021 ttcttgcttt ttctattggt ggagataaaa gatgaaaaaa agaatcatat tattattagc 604081 agtgataata gcggcagctg ccgcgggggt tgcgttttat gttgcaaagg ataaaggcca 604141 tgagaaggct gctgatgttt cagtcaatac cgaaagcggt gatgagctgc tggtttcaat 604201 tacagatacg gatctgctga caaagtatta tgaaaatgac aaggtgatcc atgaggagaa 604261 gctgaccagc tatccggcat ttgccttgga tcaaaaacag caggtgctct attatacggg 604321 caataatgaa cagaatgaaa tgaggctttt taaattggat ctgaagtctc ataaaaaaac 604381 gatgctttat aaaggcgcgg agagtgcgga cagtttattt ttatcaaagg accgttcaac 604441 catctatttc cgcttaggaa aagcggacga aagcaatttt cgaatcgccg cttttgatct 604501 gaagacgaaa aagtataaaa atctttatcc tgccgctaat gatcaggatg acaccgtcag 604561 cagcttcttt tataaccaaa aaaacgattc atttgcattg cttcattatt ctgtagaaga 604621 agactacaag aaaacagatg aagcaaacga aaagggcatc gaccctgaac cgacaacgat 604681 tcattttgcg gaaggccgcc aaaataaatt taatgagctg aaaagcctga accaatttat 604741 cagcgatatt gctgtttctg atgatgataa acgtatttta ttcacatcat atacgcaaaa 604801 aggaacggag caaaccgctt ctattcaaat gctcaatgcg gatacgaaaa aatatgaaag 604861 catcatctca aatcaaaaat catttaagct gttaattgac gcacagcctc agttttctaa 604921 ggatgggaag aacatttatt ttcttgccga agccaagggg gctaaaaagc tgaaggacga 604981 aacagggcgt gaagctaagg tgcggacgat ttattcctat agccttgaga ataagacctt 605041 caaaaaagta tgggaaaatc cgaacggcat catcaacagc ttttttgtga ttaactaata 605101 aaaaccactc ggcatgagct gagtggcttt tttaatggat gaggtgcagg gctaatgatc 605161 cgagccattt aaagatatga atcagaggta ccgacaaaaa cagaagttca acatatgagt 605221 tcattgcaac attcagcttt ttgaacgcag ctcttttttt caagtctttt tgctgctggt 605281 ttgagatcac gttatcactc ctcttatatc catattatac cattaaaaca gacaaaaaag 605341 ccctaaacgt ttacagtttt gggcttcttt cttcgtattt ggcctcttgc aatgagaggc 605401 ttttattctg aaatatagaa ttttgtctcc gttcggggtt tgtttgcttg cgggagactg 605461 catttgttat agggaagaac tagcttgttt tcgtttggct gttgttttgg agattcacta 605521 atgaacggat gccgtcgacc attttacttc cgcacaaagg gcacaatggc gtatcactgc 605581 tggcgaagtt ttttcgggtc cagccattac agtcttcttt tgtgcattcc caagtactca 605641 catcttcctt tggcagcggt tcttgatttc gtttgttata gtaagacata aagtcacttc 605701 ttccctcatg tattttactg cacatttcct attgtctcat acttttccct aatctcctaa 605761 ttcctttttc tttatgactt tccaataacc ccatctaaaa aggagaggag tgtgctgtta 605821 aaagcatctg gctcttctaa aaacgggcaa tggctgcttt taggaaaggt aacgagtgtc 605881 gcgtttggaa tattgctgcg caagtgttcc ccagctgctg tagagaaaaa tttcttgtct 605941 tccccgaagc acagcaatgc cggcacattg atgttttgga gggtgccccg gtaatcagcg 606001 gccgtttggt taaataaaat cgtgctagaa atggcagccg gctgtttgag gatttctgcc 606061 agcatccatt ctgtttcggt ctcggcaggc ggttctgcga acatattctg gatgaagctt 606121 tcgtagaaag gcagcgggtc agtttgaatg gcgtgcatcg ctgtttttaa gccgtcaaaa 606181 tcaaatggac catgttccca gccctcccat tgatagtccg aagcggattg atcgatgatc 606241 acagcggctt gaatgttatc attcccaaac tgattgagat aatcccatac gacaaaagca 606301 cccattgacc agccggcaag aacgacatga tcaagctcca ttgcatttag aaattccctt 606361 atgtcacggg catattggga aatggtgtgg ccgtgaagca ctttgtcaga ttcgccgtgt 606421 cctctaagat caagacgaat acattgataa ttggcagaaa gcaccgaaaa ttgtttgtgg 606481 aaaaattgtc cgctcatcag caccccatgt ataaacagga tcggcgtccc gctcccgtgt 606541 gtttcatagt aaaggcgtgt ctgatcttct aatatgatgt atggcatgtt tctcctcctt 606601 tagtttccat catgagtatg gctggctgct gttgagctga tgatggcagc tgtcgcggct 606661 gcctgctgcg cttgaatgac tgtttcgata gcggtgtata gtcctgattc catcagcaga 606721 tttttctcca tatgctcact gagatagagg ctgacagcaa ttttaaagtt catttccttt 606781 tgccatttaa aagctttttc ctggtttaat tcgtcagtga tgcacaaaac ggttttgata 606841 tctggctctt ccagaaatgt gaggagagca aggtctggat aatgataatc ctttgttttt 606901 ttgacagatt cagtgatcga ttgatatatc tgtttgcaag cggaaacaag catttcgggc 606961 tctttttcac tttgcaaggc cagaatatgg ctgacctgat gtaagtactg tcctttttta 607021 aagccgttgg ctgccagcag ttgatagcat gtttccgcct tctgtagcgc ctgcaaacct 607081 tttccgtttt ctccaagcag tacggcaagc ggaacattct gagttgaagt gaggaaataa 607141 tgatttttct tcatctgctg ataaacagct agccccatgt tcatctgttc tttttggttt 607201 gtcgtttcag atttgccggt gagcaagatc agagcggaaa ggtatgtgaa catatcccgc 607261 ttatacccta gcttcaccat ttcattgtat acatcgatga aagtctgaaa tgtttgtttt 607321 gcctcatgct gaaaatgaat gtccagaata gatgcaacag taaagcggtg gtgtgaattg 607381 agtgttgaga agctgccgat gtttgatttg atatagctgc tcaaatcata aaagcgctga 607441 aaatcaaact ctcttttatt cacaatatat gcagaagaaa tgagcattaa tatctgatcg 607501 tgtgaaactt tccattttaa ttttgttttt aattcagcat aaatggaaat gtaatgcttt 607561 gttttttcat gtagatcgtg tgtgagcata aaaagcagct ccttttgttg tttttacgta 607621 atacgataaa tagggccaaa ggtttcataa agaaaaaact tgcctgctag aggcaagttt 607681 gtcgggttat ttatggggat cagttatatc catcggtctc atcatgtcat agtcttcatg 607741 ctctagaata tggcaatgcc atacgtatcg tccgctgtac ggaccgaatg tcgccgcgat 607801 tctcaggact tcacctgcat gcgcttgaat ggtgtctttc cagccctttt cacttggcgg 607861 cggcgggaca gccggaccgg tataggacaa ttccccgctt tcttgataac gggcgatatc 607921 aaacggccgc cggtctaata cacggaagga gactagatgc aggtggatcg gatgtgttcc 607981 gcgtgtcggg ttgataatgg accatatttc agttgtgccg acttttggtg tttctgtgac 608041 gggatcgtgc cagcgtttgt tattaagcag aaggacgggt ctgccgtatt cgtcctgggt 608101 gcctgccagt tttaacgttc tgatgttttg tattctttca tgctgtaccg aagggtatga 608161 ggcgaggtac ttcggctttc tgctttcgtc tttttgtgcc aatggttttg tgactctgaa 608221 ttgcatgata ttcgcatctg tttcaggatt gacgtcaccg ccgcagcccg cgctgtttgc 608281 caaaatgatc gattctcctt catatgctgt gaagtcaatg atgatatcgt aacgttcagc 608341 aggcgcaagg ctgaaagaat tcagtttaac agatcgcggc aggagccctc catctgaacc 608401 aatctgaata aaatctccgc cattatcgag tgacaggtta taggttcttg tattggaggc 608461 gttgatgaca cggaatcggt atttccttgg ctcgacttcc aagtatggcc ataccttccc 608521 gttgacgagt atggtttctc cgcaaaaagc cggaacgatt gaaggattag gcagtgacgg 608581 agaagggttt tccggtgcgc tcggataaaa caaagaacca tcctcattga tcgtgcggtc 608641 tgtgataaga agcggcacat cgtattcgtc tgaaggcagt tttaagcgtt tttcctttgg 608701 gtcatgaatg atatatgcac cgacaagtcc ggcatagaca tttagcctgg tgagcgccat 608761 ggcgtgatcg tgataccaca atatagcccc gcgctgctgg tttggataat gataaacctc 608821 tcttttgaaa taaggtcctg tttgttcaaa gtctttggaa aaccaagcct ccggataccc 608881 gtcactatca tctggcgtga cgccgccgtg taaatgaaca acagtcttta cctcgggctc 608941 ttcatgctgg ctgtcactgt gatgaatggt gtgatcaatc ggaaggaaat gcgtggaagg 609001 aaggttattc atccatttta catatacgtt ttcatttctt ttaacctcaa tggtcggtcc 609061 cggaaataag ccgttgtagc cccacaggcg ggttggaggg agatcgcgat ggagctgatg 609121 agtgcattcc tccatggtga cttcgtagta tgttttttct tttgattgct gtactggctt 609181 tagtgtatct gggattggga gagcatccac aaatttttca agtgtcattt tcatctgtcc 609241 ttatctaaat tttccaaatt ggtactatag ttaatgacaa taaggacgtg atggttacaa 609301 aaaatcttcg tgctgcagcc cgcccgaaga agaaaataac aaaatcctaa acggcaggcc 609361 gtttaggatt tgatcagcat taaggcagga tatcgggttg ctgctgtgtg actgggttgg 609421 cagccgcttt ctcgctcacc ttgcgttttc tgaacacaag gtaagaaatc agaacgattc 609481 ccgtgatgac gcctgtcagc agcagctcgt ctctcatgga atcaataaac gccatggaca 609541 ctaaaattcc gcaaatggcg atgatggtca agtaggttag gaaagggaag agccacattt 609601 tgatcttcaa tgcttctggg tttgtttttt cgagtttttt ccgcattttc agctgggaaa 609661 cggcgatgac aagatagacg agtaaagcga ttgcgcctga tgagttgact aagaataaaa 609721 agacggtatc cggtgaaaaa tagttcatta cgaccgcgat ataagagaaa aatgtcccgg 609781 ccacaatggc ttgtacggga acgccttttt tgctcaattt cataaaacgg cgcggcgctt 609841 catttctttc tgcaagtgaa tacagcattc tggatgtggt atacaaacct gaattcaggc 609901 aagagagtac ggctgtgagg acgataaagt tcataatctg tgcggctgcg ggcactccta 609961 tatgctcaag tacagcgacg aaagggcttt ctaaaatatt tgctgaattc catggcaaca 610021 gcgccacgac aatggcgatt gagcccacgt aaaagacgat gatgcgccat acaacggatc 610081 tggtggcttt tgtcacagat tcgatcgggt tggatgtttc ccctgctgca atggcaacga 610141 tttcagttcc cataaaagag aagatgacaa cgacaatgcc gagcaatacg gagctgatgc 610201 cctccgggaa aaatccgcct ttgcctgtaa gattcgaaaa accgactggc tcactgcccg 610261 gtgcaaagcc aaaaataaag gcaaaaccaa cgattagaaa agcaatgata gtcacaactt 610321 taatgaggga gaaccaatat tcaaactcac cgaaagactt aacggagtag acgtttgtca 610381 gggtgagcac aatggtcaag atcaaacttg tcagccacag cggaatatca tggaaccagt 610441 attgaataat gccagcaccg gcaatggctt cgatcgctat gacgatcacc cagaaaaacc 610501 agtacagcca gccgattgta aatcctgccc acggtccgat ggcgtcgtga gcgtattgag 610561 aaaacgatcc gctcgtcggg tttacggcag acatctcacc gagcattctc ataataaaaa 610621 tcaccaataa tccggctaac gcgtaagaaa caacggcacc cggaccggtc gagtgaatca 610681 ctgaaccgct gcctacaaat aggccggctc cgattacacc ggcaatcgaa atcattgtca 610741 tatggcgggt ctttaattcc ttttttaatc ctgattgaga ctggttcata agttacctcc 610801 ttttaaaatg caatcattac tgaatattat gataattgaa actctatcat aaatatacag 610861 tttgtcgaaa attcgtgtaa gaaaatatac cagcttattt caaatttgta gtgttttgtt 610921 tgcgctttca gcgaatgtgt ggaaaaaatg tttcgttttt tattcgctgt gtgattttgc 610981 gtaatattta caattcgata gaatgcgaga agcactggtg tccttgggtt tgatgggatt 611041 tttggcggag caaataaatt ggatgagaga aaaagtgttc cttcgtcact atttttctgt 611101 ggcgggtgaa tcatgtttct gtagacccac tgcggatcag ctttgtaaga taataatagg 611161 aaaatgtgag cgagaggagg ttttgtatgg agagatatga tgaactgaaa aagggagaat 611221 ccggagcgct ggtcagcatt gccgcgtatc tagttctttc cgcaattaaa ctgatcatcg 611281 gttatctttt tcactcggaa gcacttacgg cagacgggtt aaataacaca actgacatta 611341 ttgcttctgt tgctgtgctg attggcctgc gcatctctca aaagcctcct gacgaagatc 611401 atccatacgg ccactttcga gcggaaacga ttgcatcgct tatcgcatcg tttattatga 611461 tggttgtcgg actgcaagtg ctgttcagcg ccggagaatc tattttttct gctaaacaag 611521 agacgccaga tatgattgcg gcttggacgg cagcgggcgg ggcagtcctg atgctgatcg 611581 tttaccggta caataaaagg ctggccaaaa aggtgaagag ccaggcgctc cttgctgcgg 611641 ctgctgataa taaatcagac gcattcgtca gtatcggcac atttatcggc attgtggctg 611701 ctcaattcca tcttgcttgg attgatacgg tcactgcgtt tgtgatcggt ctgcttattt 611761 gcaagaccgc atgggatatc tttaaagagt catctcactc tttgacagat ggattcgaca 611821 taaaggacat ttccgcttat aaacagacaa tcgaaaaaat ctccggtgtg agccgtttaa 611881 aagacataaa agcaagatac ttgggcagta cggttcatgt tgatgtggtg gttgaggtat 611941 cggcagattt aaatattacg gaaagccacg atatagccaa tgaaattgag cggagaatga 612001 aggaggagca tgcgattgat tattcgcatg ttcatatgga gcctttagaa caaaaataat 612061 ggagcttcct gtcacaggaa gcttcagcgt gtcgacaaac cctcgcattc gttgtcaggt 612121 ctgcgcttcg gtgctcacga attagaacat tcgctccgct cctatgctcg tccttcctag 612181 acttcaaggg ttttcaatca cgctgaaaag atgacaaaac cctaaaatga aagccatttt 612241 aggattttgt caacaatctg gagcttcctg ccacaggaag cttttttgtg tgttttggcc 612301 agctttattg gtaacaattt gctagaatcg tttttttata cagattgctt tttgtggtaa 612361 agttaggtta cattatgatg aattttgtag atgactagga ggaaaataat ggcatatcaa 612421 gaagacctgc atcctttgct ggggaaagca gttgaacata ttaatagagt aatggttgga 612481 aaacgagaca tcgccatact cagcttagca gcccttcttg ccaaagggca tgtgctgctt 612541 gaggatgtac ccggagtcgg aaaaacgatg atggtccgcg cgctggcaaa gtcaatcggc 612601 gccgatttca aaagaatcca attcactccg gatttgctgc catctgatgt aacaggggta 612661 tctatctata atgcgaaaac gatggaattt gaatatcgtc ccggcccaat tatgggaaat 612721 atcgtgctgg cagatgaaat caaccgtacc tctccgaaga cacagtcggc tttgctcgaa 612781 gcgatggaag aggggagcgt cacggtagat ggccatacga tgcagcttgc cgatccgttt 612841 tttgtgatgg caacgcaaaa cccggtcgaa tatgaaggga cctatccttt gccggaagct 612901 cagcttgacc gttttttatt caaacttcgg atgggttatc cgtcctttaa tgaagagctt 612961 gacgtcttat ctcttcagga aaaaagccat ccgattgaga cgcttgagcc ggttattgca 613021 aaagaagact tcatcttttt acagagggaa gtgcaaaatg tccgtgctga tgacagcatt 613081 aaggaatata tcgttgaaat tgtgcagaaa acgagacagc atccttctgt tcaattaggc 613141 gtcagtccgc gcggctcaat cgccctcatg aaagcggcac aggcatacgc gctgctgcat 613201 catcgcgact atgtcatacc ggatgatatt caatatttag ctcctttcac gctgccgcac 613261 cggatgatgc ttcatcctga ggcaaaattt gaagggattc aggcagaagc gatcgtaagg 613321 gagatcatgt cagctgtgaa ggtgccggtt caaaggtcgg cggtccgctg atgaataaga 613381 aatggcaatg gctcgtatat ggttggaagc tgattatatt aactttattg acggctgctg 613441 ttttttctta tgcgatgttt cagggcggct ttgtcagctg gtttttgttt tacgcgtttc 613501 tcccttttgt cttgtatgcc gggctgttgg ccttgtatcc gctccgttct tttcaggctt 613561 caaggcaaat ggataaaaca caattgcatg cgggggacag gctgggcgta acggttacgc 613621 tgagaagaaa gctgccattt ccgctgatgt atatggtgat tgaagattgc ctgccagaag 613681 gtatcgagtc attaaatcga gacggagccg cggccaaacg gctcgttttt ccttggttta 613741 aacggagcat gacgatgtcg tatgaattag ctcgggtacc gcgcggagag catcactttc 613801 attctgtcag ggtgcgaacc ggggatgttc ttggcttgat tgaaaaaaca gcattttttg 613861 agctggatga taccttgttt gtttatccat tctatcagcg tttttcctat caggtgaatg 613921 agaggcatca ggaagacggt gtaagcggtt cttctcctat tcatcagcac cattcctcag 613981 tcgcagcaag tgtgcggaat tatcagccgg gagaccggtt tgctgcgtta gattggaaga 614041 catctgcacg gcggagccag ctgatgacga aggaatttga gccttctcgc agcaaaaatc 614101 tgtttctgct gatggaccgt ttttcctcag acgcattcga agaggtcgtt tcagtgacag 614161 cttcgattct tcattctgtt ttaaaaaacg gcgcgggtgc tggtctggct tccatcggga 614221 aggaaaaaaa cattttccct attcaggaag gggatcagca ttttaagcac atgcttcggc 614281 atttagccat cgctcattgt gatgcggcag acccgataag ccgatatgca cgggaagagc 614341 tgggaaagcc atctgttcgc caagctgatc aagttgttgt cacgggacag ttaacggaag 614401 atatgctgca cctcgcagaa ataggaggcg gccgggttac ggtgatactg gcaaaagaga 614461 aagatgctga gctctctcaa gctgaaaatg tcatgattga acgcatgatg aaacgccaaa 614521 tcagagttcg gatcatgagg ggcgggcgag tttcgcgtgt tgtttagaaa gagaggtgac 614581 tggttcacat gccgcacgat gatcacaagg gaagccgttt gagcttgctg ttattttatt 614641 ttctggcttt tttattgctg tgggagtggc ttaggccgct tgacagtttt actgaaacga 614701 aacatacagg cttttttagt gtctttatcg gcttgacgtt tctgctgact tttttcagga 614761 tgaggtggtt tgtcaccgtt cctttttgtg tcatatttac attgatctcg atacacatcc 614821 tgttttatca aggatctata ttcgacttga gctgggtcag ctcttttttg caggatgtct 614881 atctgaatat cacgctgatt caatcagggc aatggaatga catgattcct tcatttcgga 614941 ccctgctgtt ttttgtgctg ctgtggctgc tggtctatct cctgcattat tgggtgattt 615001 accagagaag aattttgttt ttctttttga tgacagtagc gtatattacg attcttgata 615061 cctttacgcc atatgatgcc acttttgccg taatccgtat cgtgctgatc ggcttcttta 615121 tgctgggcct tttatacttg gaacgcatta agctgatgga aagaatcaca ctgccaaaaa 615181 catctgtcct gaaatggttt cttcctttat ctgtattggt tttggctgca acgggattcg 615241 gactcgccgc tccaaaatca gagccggctt ggcctgatcc ggtgcctttt cttaaaaaaa 615301 tcactcatca agaccgcgtg tctgcagggg aaagcaaaat cggatacggg aatcatgatg 615361 aatcactcgg cggcccgttc cagcaggatg ctacacctgt ttttacatgg cagggaaaag 615421 agcgtacgta tttccgtgtg gaaacgaagg acacgtatac cggaaaaggc tggattgaaa 615481 cagacacagg catgtcgtat cagcttagca atggaaaagt tgaaaatctg tggtttgacc 615541 ataaggttgc gacagagcgc cgcaccgtcc gtgtaaaagt cgataagcac tacgggtata 615601 accatctgat gtatccgatt ggtgcggaaa ccattcagcc aaagcaggct gtctcacttg 615661 aaatgaacgg caacacggag caaatttctc cgatcagtga acaagccggt gaaatcagaa 615721 atatggggaa ttatacagta acgtacaatt ccccggtcta taagctggat gaactgagaa 615781 aggtaaaagt gagaaaaaac agtgaggagt acacattcag cgatcgctac atgcagcttc 615841 cagattcact gccagagcgg gtgagaaccc ttgcgatcaa actgactcag gatcacgaca 615901 atatgtttga taaggtgaaa gcggttgagg actatttagg gtcaaatgcg ttcacatatg 615961 aaacagaaaa cgtgaccatt ccgaagaatg atgaagatta tgtcgatcaa tttctctttg 616021 aaacgaaaat gggttattgt gataactttt cttccgccat ggtggtgctc ttgcgctcgg 616081 ccggcattcc ggcccgctgg gtaaagggtt atacgtccgg cgaatacaaa gaagcaggga 616141 acaaaaatgg cagcatttac gaagtgacaa ataacaatgc ccattcctgg gtagaggtgt 616201 atttcccgga acagggctgg gttacatttg agccgactaa agggtttaca aatccggctc 616261 aatttacatc ttctgacaca aaagactctg gcagcgatag cagcagctcg ccgaagaaag 616321 caaaagagaa acagaaagaa gagaaaaaac agccgcaaaa agaggaaaaa caaaaggaaa 616381 agcgggagcc agctgtttct aaaaagccgt ccgcttcgca tactaatgcc ggtgcgggct 616441 tgtatgcagc gcttgcggtt cttgcagtcc tcctggtggc agctgtattg ctgtatgttt 616501 tccgctcgtt atggattcct gttttcgccg tgaggaaatt gaagcggcgc agtgatcagc 616561 acgcgttttt tgaggcatat ggcgcgctgc tgaaacaact gaagagaaaa ggactgccga 616621 aacgagacag tgaaacgctg cgtgattatg caaaacgaat tgatgaaaaa tacgacatag 616681 aagacatgtc aaagctgaca ttaagctatg aaagggcgct ttacagaaat gaagattctt 616741 cggcgctatg gaatgattcg agagagttat gggaaaattt aattaaaaga agatggtctt 616801 gaccgcttat cgacgtgttg ttagaattag tgaatattat cggagtctgg gagcgagttg 616861 gcctgactcc ggcaaacggc cttgccaaag agggcggagc gagcttcata tctgtcctcg 616921 tttttttctg tgtcaaaaaa cttagaggag attaggtgac aaccatgaca aagttagtga 616981 atgaaatgat tcttgtcctt gatttcggca gtcagtataa ccagctgatt acacgccgta 617041 tccgtgaatt cggtgtttac agcgagctgc atccacatac attgacggct gaagaaatta 617101 aaaaaatgaa tccaaaagga attattttat ccggcggtcc aaacagtgtg tatgatgaaa 617161 actctttccg ctgtgacgag aaaatcttcg agcttgatat tcctgttttg ggaatttgct 617221 acggcatgca gctgatgact cattaccttg gcggtaaagt tgaagcggca agccagcgtg 617281 aatacggaaa agcaaacatc cgcatcgaag gcacacctga tttgttcaga gatcttccga 617341 atgaacaagt ggtttggatg agccacggcg atttggttgt agaagttcct gaaggcttca 617401 ctgttgacgc gacaagccat cactgcccga actcagcaat gagcaaagcg gacaaaaaat 617461 ggtatggcgt tcagttccac ccggaagtgc gccactctga atacggcaat gatcttctga 617521 aaaactttgt attcggtgtt tgcgaatgcg aaggcgaatg gtcaatggag aactttatcg 617581 aaatcgaaat gcaaaaaatc cgtgaaacgg tcggagacaa acaggttctt tgcgcgctaa 617641 gcggcggcgt tgattcctct gttgttgctg ttttgattca taaagcgatc ggcgaccagc 617701 tgacttgtat ctttgtagac catggtcttc tccgtaaagg cgaagctgag ggtgttatga 617761 aaacattcag cgaaggcttt aacatgaatg tgattaaagt agacgcaaaa gatcgattct 617821 taaacaaact aaaaggcgtt tctgatcctg agcaaaaacg caaaatcatc ggtaatgaat 617881 tcatttacgt gtttgatgat gaagcggaca agctcaaagg catcgactac cttgcacaag 617941 gtacgcttta cacagatatc atcgagagcg gtacagcaac ggcgcaaacg atcaaatctc 618001 accacaatgt cggcggactt cctgaagaca tgcagtttga gctgatcgag ccgttaaata 618061 cgctcttcaa agacgaagtg cgcgcgcttg gcacagagct cggcattccg gatgaaatcg 618121 tatggcgtca gccgttccca ggaccgggac tcggaatccg cgttcttggc gaagtaacag 618181 aagaaaaact tgaaatcgtt cgtgaatcag atgcaatctt gcgtgaagaa attgcaaatc 618241 acggcttaga gcgtgatatc tggcaatact tcactgttct tcctgacatc cgcagcgttg 618301 gtgttatggg tgacgcaaga acatatgatt acacaatcgg aatccgcgcc gttacatcaa 618361 tcgacggcat gacatctgac tgggcgcgta tcccgtggga tgtgcttgaa gtcatttcga 618421 cacgtatcgt aaacgaagtg aagcacatta accgcgtggt gtatgatatt acaagtaagc 618481 cgcctgcgac gattgagtgg gaataagaat caattaatgg aaaccatctt tttggcaatt 618541 ttgccgggaa gatggtttta tttgtttatt acgaacaaaa tccgattttg cgcgactatt 618601 gttcgctttt tgtattgttt tttcaaaatg aacttggtac aatagacaca gaaatcaaat 618661 aagatgaatt cgtataatcg cgggaatatg gctcgcaagt ctctaccaag ctaccgtaaa 618721 tggcttgact acgtaaacat ttctttcgtt tgatataaat aaaacacggt tatttattca 618781 aactgaaatc cgtctgtagt caagcgtccc aaaatgtatt gggacgtttt ttatttggcg 618841 ttttcaggac agaataaata gcaaagagtg aagggagtca aatagcttga aaacgttttt 618901 tcagtttgat gagctgggca ccagctatcg caatgaaatc attggcggat taacgacttt 618961 tttatctatg gcatatattt tgttcgtcaa tccgattacg cttgctttgg agagcgtgaa 619021 agattttccg gaggcgctga gaattgacca gggtgcggtc tttacggcga cagcgctggc 619081 gtctgcagca ggctgtatct taatgggatt aatagcgaga tatccgattg ccatcgcgcc 619141 gggtatgggg ctgaacgcgt tttttgcgtt ttctgttgtc cttggtatgg gtatttcatg 619201 gcaggcagct ttgtccggtg tttttatttc aggtcttatt ttcgttgctc tttctttaac 619261 aggttttcgt gaaaaaatca tcaacgccat tccgcctgag ctgaaattgg cagtcggtgc 619321 ggggatcggc ctgtttatta catttgttgg attacaaggt tcaggaatca ttacagcgaa 619381 tccttctacg ctcgtcacga tcggaaacat tcacagcggt cctgtgctgt taacgatttt 619441 cggtgtgatt gtcacggtta ttttaatggt gcttcgcgtg aacgcaggcg tgtttatcgg 619501 gatgctatta acagcggtag ccggcatgat tttcggtttg gttccggttc cgactcaaat 619561 tatcggcagt gtgccaagcc ttgcgccgac tttcggacaa gcgtggattc acctcccgga 619621 tattttctct gtacaaatgc tgatcgttat tttaacattc ttgtttgtcg gattttttga 619681 tacagctggt acacttgttg ctgtggcaac acaagctggt ttaatgaagg aaaacaaatt 619741 gccgcgtgcg ggccgtgcgc ttttagctga ttcatcttct attgtgatcg gtgccgtgct 619801 tggtacgtct acaacaactt cttacgtgga atcaagctca ggtgtcgctg cgggtgcccg 619861 gtcaggattt gccgcaattg taacagggat tctcttttta ctggctacgt ttttctcgcc 619921 gctcctatca gtcgttacgt caaatgtaac agcgccggcg cttattattg ttggtgcatt 619981 gatggtggcg ccgcttggca aaatcgcttg ggataagttc gaagtggccg ttcctgcttt 620041 ccttaccatg atcatgatgc cgttaacgta cagcatcgcg actggtattg ccatcggatt 620101 tattttctat ccgattacaa tggtgtgcaa aggaaaagca aaagaggttc atccaatcat 620161 gtacgggctg tttgtcgtat ttatcctgta ctttatcttc ttaaaataag gaatgaaaaa 620221 ccagctgcac tggcagctgg tttttttgtt gcaaaagata aaaccatttc atacgatata 620281 ccgtcatgta gatgtgccgc catgctttac ttaaatggaa atgacttgac tgttcaggaa 620341 ggcttcggta ccttatataa gtgttttatt ttcttgctga atggtattcc gccgtatttt 620401 tttgatagga gttgctgaca tgacggaaga aagaaaagaa acgtttgaag aagaaattaa 620461 ccagagtgaa agaatagatg cagatgaaga accgctatcg agaatgtcca gaaaggcgag 620521 ccggcaaagc aagcagaagc aaaaacaaaa gcagaaaccg cgccaggaac gcggtgaatc 620581 aactgttaaa gacaagcttg cgtctgtttg ggcagccatc aacagatatt gcggttttgc 620641 gttctcgatt ttaaaatctc cggcgaaaac tgtcgtaacg gatggttttt ctcattataa 620701 gtacggtctg atttcaatgc ttatattcag tatcattttt tcaattggga attggtttca 620761 gttaaaggca agctggaatc ggccgctcgg tttcggagaa cgccatcatg ctttctatga 620821 cgggttttta gttgttcttg tgtatttgct gatctttttc gcggtaatgg tctttgctat 620881 atgggctgtc tcccgctata tgatgaagca gaaggtgacg ttcagagaag cggctgccgt 620941 attgggttca ttgcttgtac ccgtaattgc tgtttcaatc ctttggctga tctttgcgat 621001 cgtaaatatc ccaatgctga cagtactgtt tacggtgctg atcttgtttt ccatcttttt 621061 tatcatcgcg ctgtatgtac agcgtgtgta ccaggcggca caagatgcac caattgatta 621121 tatctattgt gtatttgcag tagttgcgat agcgctgctg tttacggcag tgacttggcc 621181 gtttatttct gaatatatta cggcgtcgtt gattccgctt taatgaaaaa accggctaat 621241 cctagccggt ttttttatgt cacacttttt acaaatatat ctaaaaaaca tagttgattt 621301 gtaggattaa cccgtgtatg atggggaaaa tgctgaaaac gtccagcgca aaaaccttta 621361 tgtttaagga ggatgatgga catggctgat gtacttcgcc gagcaattaa ccaaaagaag 621421 caatttttaa aaaccaaatt actgctctcg gaattttatc aaggaagagg ggaacagctt 621481 gctgactaca cgctgagtga gcttgagaaa gaatacaagt cccttcagaa aatgaaaaaa 621541 gagatctgac aatagatata aagaggtgag tctgctgaaa agcgggcttt tttgttttga 621601 ttttgaaaag gcgagaaaga gggtaaacta ctactgttca acacataaaa gcgtgtcgaa 621661 atattttgct taagcttacg ggcgaagctg attgtaaacg gctcatttct ctagtagaat 621721 atgaatgctt tgtgcaagct gaagagtagg gggatgaata aaatgatgca aaccatctta 621781 tcaaatggga tagccatggt tctcataatt ctcattatta atattgtcta tgtgtcattt 621841 tttacgataa gaatgatttt aacgctgaaa ggacagcgtt atttagcggc cggcatcagt 621901 acgattgaaa tactggttta tgtgacagga ctgagtctgg tgctcgataa cttagaccag 621961 attcaaaatg tgatcgcgta cgcgctcggt tacggtcttg gcgtaattgt cggcatgaaa 622021 atagaagaaa aattggcgct tggctatatt atggtcaatg tgattacgaa ggagctcgat 622081 cttgatcttc cgaagcagct ccgtgaaaaa ggctacggcg tgacaaactg ggtggcaggc 622141 gggcttgaag gcgaccgcac agcccttcag atcctgacgc cgagaagata tgaactccag 622201 ctatatgata cgattaaaac acttgattca aaagccttta ttattgcgta cgaaccaaaa 622261 acaatccacg gcggcttctg ggtcaaagcg gtgaagaaga ggagaattaa agaataatgg 622321 caaagccgaa gaagaaaaag tttgaagtga cagagcagca aacgattgat gcggtgcttc 622381 agcaaatgaa agaagaagga tatctgcctg taaggcgaat ggaagagcct atttttatgg 622441 aaaaaaagga aaatgggtca attcagatcg ttccgtgcgg gaaaaaaatc gtatttgaag 622501 ggaaattgat ctaaaacacg aacattagta gaatgaattt ttgtatcgtt cgataatatc 622561 gttgacatta tccatgtccg ttgttaagat aaacatgaaa tcaaaacacg acctcatata 622621 atcttgggaa tatggcccat aagtttctac ccggcaaccg taaattgccg gactatgcag 622681 gaaagtgatc gataaaactg acatggatat atcgcagaag cgaacgactg acgatacatg 622741 taccatgccc ggtttgtatt gcttcctcat aagtgcaatg cagagcgggt attttttatt 622801 ttctgaaaac aaaagcatta gaaggtgggg aacagaatgc agccgctagt aggaatcatc 622861 atgggaagca cttccgattg ggagacaatg aaacacgcat gcgacatact tgacgaactc 622921 aatgttccgt acgaaaaaaa ggtcgtttcc gctcaccgga cgcctgattt catgtttgaa 622981 tatgctgaaa ctgctagaga aagaggcatc aaggtgatta ttgccggtgc cggaggagcg 623041 gcgcatctgc cagggatgac ggctgcgaaa acaacactgc cagtcattgg agttccggtt 623101 cagtccaagg cgctgaacgg aatggattca cttctttcca tcgtccaaat gcctggaggc 623161 gtgcctgttg cgacaacatc catcggcaaa gcgggtgctg tgaacgcagg cctgttagcg 623221 gcgcaaattt tgtcagcatt tgacgaagac cttgcccgta agctggatga gagaagagaa 623281 aatacaaaac agacagtgtt agaaagcagt gatcagcttg tctaaacaaa tcatctatcc 623341 gggagctgta atcggcatta tcggcggcgg ccagcttggg aaaatgatgg ctgtgtccgc 623401 caaacaaatg gggtataaag tcgcggtcgt tgatccggtg aaagattcgc cgtgcgggca 623461 ggttgcggat gtcgaaatta ccgctcatta taatgaccgt gaagcgattc gaaaattggc 623521 tgaaatcagc gatatcatca catatgagtt tgaaaacatc gactatgatg cgctgcattg 623581 gctaaaagat catgcgtatc tcccgcaagg aagtgagctg ctgcttatta cccaaaaccg 623641 tgaaacagag aaaaaagcaa ttcaatccgc gggctgtgaa gtcgcaccgt acagcatcgt 623701 caaaacaaag aatgaattga aacaggcagt acaggagctc aggcttccgg cagtgctgaa 623761 aacatgccgc ggcgggtacg acggcaaagg ccaatttgtg ataaaagaag aggcgcaaat 623821 ggagcaggca gccgctctgt tagaacacgg aacttgcatt cttgaaagct gggtttcttt 623881 taaaatggaa ctgtcggtga tcgtcgttag atcggtaaac ggtgaaattt caacatttcc 623941 gacagctgaa aacattcacc acaacaatat tcttttccaa agcatcgtgc ccgcacgggt 624001 agagaaaggg attcagcaga aggctgctga tctcgcagtt aagcttgcag atgagcttaa 624061 ccttgtcgga ccgcttgctg ttgagatgtt cctgacagag gacggagagc ttttggtcaa 624121 tgaactggcg ccaagaccgc acaattcagg gcattatacg ctggaccttt gcgagacgag 624181 ccagtttgag cagcatatca gagcggtatg cgggcttccg cttgggaaga cagatttgct 624241 gaagccgggc atgatggtga atcttctcgg cgatgaagtg aagcttgttg aggaagaccc 624301 ggagctttta aaagaggcaa agctatatat atacggaaaa catgaaatca aaaaaggccg 624361 caaaatgggg catattacat ttatgaagca gcctgaagac gaatggattc aggagatcac 624421 aaataaatgg atgaatagag acggaggaca agcagaatga tcgaacgtta ttcaagacct 624481 gaaatgtccg cgatttggac ggatgaaaac agatttcaag catggttaga ggttgaaatt 624541 cttgcctgtg aagcgtgggc ggagcttggc gtcattccga aagaagatgt aaaggttatg 624601 cgcgaaaacg cgtcatttga catcaaccgc attttagaaa tcgaaaagga cacgcgccat 624661 gacgttgtcg cttttacgcg cgctgtatcc gaatcactgg gcgaagaaag aaaatgggtg 624721 cattacggct taacgtcaac tgacgttgtt gatacggctc tttcctactt attaaaacag 624781 gcaaacgata ttttgctcaa ggatcttgag agatttgttg acattataaa agaaaaagcg 624841 aaagaacata aatacacagt catgatgggg cgcacacacg gcgtacacgc tgagcctaca 624901 acattcggct taaaacttgc gctttggcat gaagaaatga aacgtaatct tgagcgcttc 624961 aaacaagcga aagcaggcat cgaggttgga aagatttccg gtgctgtcgg cacatatgcg 625021 aacattgatc catttgttga acaatatgtc tgtgagaagc tcggattgaa agcagcaccg 625081 atttccactc aaacccttca gcgtgaccgc catgctgact atatggcaac acttgctttg 625141 atcgcgacaa gcatcgagaa attcgctgtg gaaatccgcg gactgcaaaa gagtgaaaca 625201 cgtgaagtag aggaattttt cgcgaaaggg caaaagggtt catctgcaat gccgcataaa 625261 cgaaatccga ttggctctga aaacatgaca ggcatggcgc gcgtgatccg cggctacatg 625321 atgacagctt acgaaaatgt tccattatgg catgagcgcg atatttctca ttcttcagca 625381 gaacgaatta ttcttccgga tgcgacaatt gcgctgaact acatgctgaa ccgcttctcc 625441 aacatcgtga agaacttaac ggtcttcccg gaaaacatga agcgcaacat ggaccgcact 625501 ctcggcctta tctattctca gcgtgtgctc cttgctttga ttgacacagg cctgactcgt 625561 gaagaagcct atgatacagt tcagccgaaa gcaatggaag cgtgggaaaa acaagtgccg 625621 ttccgcgagc ttgtggaagc ggaagagaaa atcacgtcac gtctttctcc agaaaaaatt 625681 gctgactgct ttgattacaa ttaccatctg aaaaatgttg atctgatctt tgaacgttta 625741 ggtttagcat agaagaagct tttagcggct tcttctaagc cgccgcagtt tgaaaattcc 625801 caacattcgg gttaggaggc cttccgtgaa tattgtgaag aatgaacttt tatacgaagg 625861 aaaagcaaaa aagatctaca aaaccgatga cgaaaacacg ctgtatgtcg tgtataaaga 625921 ctccgccact gcctttaacg gcgagaaaaa agcagaaatc agcggaaaag ggcgcttaaa 625981 taatgaaatt tcaagcctca ttttcaaaca ccttcatgct aagggcatta acaatcattt 626041 tatcgagcgc atttcggaaa cggagcagct cattaaaaag gtaacgattg tgccgcttga 626101 agtcgtggta agaaatgttg tggcaggaag catgtccaaa cgtctcggca ttccagaagg 626161 cacggagctt gagcagccga ttatcgagtt ttactacaag gatgacgcgc tgggtgatcc 626221 gctcatcaca gaagatcata tttggctttt gaaggcggcg actcctgagc aggtagaaac 626281 cattaagtcc attacaacaa tagtaaatga agagcttcaa agcatcttcg acgattgtca 626341 tgtcagatta atagatttca agcttgaatt cggtttagat gcagaagggc aagtgctttt 626401 ggcggatgaa atatctcctg acacatgccg cttgtgggat aaagaaacga acgaaaagct 626461 ggacaaagat ttattcagac gcaatctggg aagcttaacc gacgcatacg aagagatttt 626521 caatagactg ggaggcattc atcatgtata aagtaaaagt ttatgtcagc ttaaaagaaa 626581 gtgtactaga tccacaaggg agcgctgtcc agcatgcctt gcacagtatg acttacaacg 626641 aagttcaaga tgtgcgcatc gggaaataca tggagcttac cattgaaaaa tctgaccgtg 626701 atcttgacgt gctagtgaaa gaaatgtgcg aaaaacttct tgcgaacaca gtgattgaag 626761 attatagata tgaggttgag gaggtagtcg cacagtgaaa tttgcggtga ttgtgttacc 626821 cggctccaac tgtgatatcg atatgtatca tgctgtaaag gatgagctcg gccatgaagt 626881 ggaatacgtc tggcatgagg aaacaagcct tgacggcttc gacggcgtgt taattccggg 626941 aggattttct tacggcgatt acttaagatg cggcgccatc gcccgatttg cgaatattat 627001 gccagctgtc aaacaagcag cggctgaagg aaaacctgtt cttggcgtct gtaacggatt 627061 ccagatttta caggagcttg ggctgctgcc aggcgcaatg agacgcaaca aagatctgaa 627121 gttcatttgc cgtccggttg aattgattgt tcagaacgac gaaaccttat tcacagcttc 627181 ctacgaaaag ggagaatcga ttacaatccc ggttgcccat ggtgaaggga atttctactg 627241 tgatgacgag acgcttgcta cattaaagga aaacaatcaa attgctttca catacggctc 627301 taatattaat ggaagtgtca gcgacattgc cggtgtcgtg aatgagaaag gcaatgtatt 627361 aggcatgatg cctcaccctg agcgcgcggt cgatgaactg cttggaagcg ccgacggtct 627421 taaattgttc cagtctatcg tgaaaaattg gagggaaact catgtcacta ctgcttgaac 627481 caagtaaaga acaaataaaa gaagagaaac tgtatcagca aatgggtgtc agtgatgatg 627541 agtttgcatt gatagaatcc attcttggaa gattgccgaa ctacacagaa atcggaattt 627601 tttctgtcat gtggtctgag cattgcagct ataaaaactc aaagccgatt ctgcgtaaat 627661 tcccgacaag cggcgagcgt gtgctgcagg ggccggggga aggcgccgga atcgttgata 627721 tcggtgataa ccaagcggtt gtgttcaaaa ttgaatcaca taaccaccca tcagctctcg 627781 agccttacca aggcgctgcg actggcgtag gcggaattat ccgtgatgta ttctcaatgg 627841 gtgcacgccc aatcgctgta ttgaactctc ttcgatttgg tgaactgact tcaccccgcg 627901 tgaagtactt gtttgaagaa gtagtagcgg gtatcgccgg atacggcaac tgtatcggca 627961 tcccgacagt cggcggagaa gtgcagtttg acagcagcta tgaaggaaat ccgctcgtca 628021 acgcaatgtg cgtcggttta atcaaccatg aagacatcaa aaaaggccag gcaaagggtg 628081 tcggcaacac agtaatgtac gtaggagcga aaacagggcg tgacggcatc cacggcgcta 628141 cgtttgcttc tgaagaaatg tcagactcgt ctgaagaaaa gcgttctgct gtccaagtcg 628201 gcgatccgtt tatggagaag cttttgcttg aagcatgtct ggaagtcatc caatgcgacg 628261 ccttagtcgg cattcaggat atgggagctg ccggtttaac aagctcaagt gcagaaatgg 628321 caagtaaagc cggttctggc attgaaatga atcttgacct gattcctcag cgcgaaacag 628381 gcatgaccgc gtatgaaatg atgctttctg aatcacaaga acggatgctt ttggttattg 628441 agcgcggacg tgagcaggaa atcatcgata tttttgacaa gtatgatctt gaagcggttt 628501 ctgtcggaca tgtgacagat gataaaatgc ttcgcctgac acataaagga gaggttgtgt 628561 gcgagctgcc tgttgatgcc ttggcagaag aagcaccggt ttaccataag ccttctcaag 628621 agcctgctta ctatcgcgag tttttggaaa cagacgttcc ggctccgcaa attgaagatg 628681 cgaatgaaat gctgaaggcc cttcttcagc agccgacgat tgcgagtaaa gagtgggttt 628741 atgatcagta tgactacatg gtgcgcacga atacagttgt cgctcctggg tctgatgctg 628801 gtgttctcag aatccgcgga acgaaaaagg cgctggcgat gacgacagac tgtaacgcgc 628861 gttatctcta tcttgatcct gaagtcggag ggaaaattgc tgtcgctgaa gcagcgcgca 628921 acatcatttg ctcaggcgca gaaccgcttg cggtgacaga taaccttaac ttcggaaacc 628981 ctgagaagcc ggaaatcttc tggcagatcg aaaaagcggc agacggcata agcgaagcgt 629041 gcaatgttct cagcactccg gttatcggcg gtaacgtatc gctttataac gaatcaaacg 629101 gcacggcgat ctatccgaca ccagttatcg gcatggtcgg cctaattgaa gatacagcgc 629161 acattacaac acagcatttc aaacaagcag gagatctcgt atacgtgatc ggcgaaacaa 629221 aaccagagtt tgccggaagc gagctgcaaa aaatgacaga aggccgtatt tacggcaaag 629281 cgccgcaaat cgatcttgat gtagagctgt ctcgtcaaaa agcactgctt gacgcgatta 629341 aaaaaggctt cgttcaatct gcgcatgatg tgtctgaagg cggcttaggc gtagcgattg 629401 cggaaagtgt catgacgacg gaaaaccttg gcgctaatgt gactgtagaa ggggaagcgg 629461 cgttattatt ctctgaatct caatctcgct tcgtcgtttc agtgaaaaaa gaacatcaag 629521 ctgcgtttga agcaactgtc aaagatgcag ttcatattgg tgaggtaaca gctgacggaa 629581 ttctggcgat tcaaaaccaa gacggacaac aaatgattca tgcgcaaacg aaagagcttg 629641 aacgcgtatg gaaaggagct atcccatgct tgctgaaatc aaaggcttaa atgaagaatg 629701 cggcgttttt gggatttggg gacatgaaga agccccgcaa atcacgtatt acggtctcca 629761 cagccttcag caccgaggac aggagggtgc tggcatcgta gcgactgacg gtgaaaagct 629821 gacggctcac aaaggccaag gtctgatcac tgaagtattt caaaacggcg aactcagcaa 629881 agtaaaggga aaaggcgcta tcgggcacgt tcggtacgca acggctggag gcggcggata 629941 cgaaaatgtt cagccgctcc tcttccgttc ccaaaacaac ggcagcctgg cgcttgctca 630001 taacggaaat cttgtcaacg ccactcagct gaagcagcag ctcgaaaatc aagggagcat 630061 ctttcaaacc tcttcggata cagaggtttt ggctcacctg atcaaaagaa gcggacactt 630121 cacgctgaag gatcaaatta aaaactcgct ttctatgctg aaaggcgcct acgcgttcct 630181 gatcatgacc gaaacagaaa tgattgtcgc acttgatcca aacgggctga gaccgctatc 630241 catcggcatg atgggcgacg cttatgtggt cgcatcagaa acatgcgcat ttgacgtcgt 630301 cggcgcaacg taccttcgcg aggtagagcc gggagaaatg ctgatcatta atgatgaagg 630361 catgaaatca gagcgttttt ccatgaatat caatcgttcc atttgcagca tggagtacat 630421 ttatttctcc agaccagaca gcaatattga cggtattaat gtgcacagtg cccgtaaaaa 630481 ccttgggaaa atgctggctc aggaatccgc agttgaagct gacgtcgtaa ccggggttcc 630541 ggattccagt atttcagcgg cgatcggcta tgcagaggca acaggcattc cgtatgagct 630601 tggcttaatc aaaaaccgtt atgttggcag aacgtttatt cagccgtccc aggctctgcg 630661 tgagcaaggc gtcagaatga agctgtctgc ggtgcgcggg gttgtagaag gcaaacgcgt 630721 cgtgatggtg gatgactcta tcgtgcgagg aacaactagc cgccggattg tcacgatgct 630781 aagagaagcg ggtgcgacag aggtgcatgt gaaaatcagt tcaccgccga tcgctcatcc 630841 gtgcttttac ggcattgaca cttccacaca tgaagaactg atcgcgtctt cgcattctgt 630901 tgaagaaatc cgtcaggaaa tcggagccga taccctctca tttttgagtg tggaagggct 630961 gctgaaaggc atcggcagaa aatacgatga ctcgaattgc ggacagtgtc tcgcttgctt 631021 tacaggaaaa tatccgactg aaatttacca ggatacagtg cttcctcacg taaaagaagc 631081 agtattaacc aaataaaact tgaaaaatga cataaaggca gcgcagttcg gctgcctttc 631141 tctttctgcc ctcgttcggg gagatatttt gaaaagcgcc ttaaaggagt gaataggatg 631201 tctgaagcat ataaaaacgc aggagttgac atcgaagccg gatatgaagc tgtaaaacga 631261 atgaaaaaac acgtggagcg cacgaaacgg cttggcgtta tgggcagcct tggcggtttt 631321 ggcggcatgt ttgacctgtc tgagctttct tatcaaaaac cagttctcat ttcgggaacg 631381 gacggtgtcg gcacaaaatt aaagctcgct ttttccatgg ataagcatga cacgattggc 631441 gtggatgctg ttgcaatgtg tgtcaatgac gtgctggcac aaggtgcaga gccgctgttt 631501 ttcctcgatt atttagcggt tggcaaagcg gacccagtga aaattgaaca gattgtacaa 631561 ggtgttgcgg aaggctgtga gcagtcaggt tcagccttag tcggcggtga aacggctgaa 631621 atgccggggc tctatacagc tgatgaatac gatattgccg gtttctcagt cggagtggca 631681 gaaaaggacg aaatcgtgac tggagaaaaa attgaagagg gccatctgtt gatcggcctc 631741 agctccagcg gccttcacag caacggcttt tcccttgtca gaaaagtgct tctggatgat 631801 gcggagctgg acctcgatac aacatatgag ccgtttgaac gcccgcttgg cgaggaattg 631861 cttgaaccga caaggattta cgtgaagcct gtgcttgccg cggtcaaaag cggaaaaatc 631921 gacggcatgg cgcacgtgac aggcggagga tttattgaaa atattccgcg tatgcttccg 631981 gaaggcttaa gtgcggaaat tgatcatggc tcatggccga tcccgccgat tttttctttc 632041 ttgcaagagt acggcaagct aaaggaagaa gacatgttca acgtctttaa tatgggtatc 632101 ggttttgttt tggcagtcaa agaagagcat ctgacagatg tgatcggaac gcttgaaagc 632161 catggcgaaa aagcctattt aatcgggcgt gtgaaaaaag gtgaaggcgt cacattcggc 632221 ggtgcggcac tttcatgaaa aagtttgcgg tatttgcatc aggaaacggt tcaaacttcg 632281 aagccatcgt cacgcgtttg aaggaggaga actgggatgc gtcagcagcg ctcctcgttt 632341 gcgacaaacc gcaggcgaaa gtcatcgaac gggcggaagc attccacatt ccatccttcg 632401 catttgagcc gaagtcttat gaaaacaagg ctgcatttga acaagccatc attgaacagc 632461 ttcgtcttca cgaggttgaa ttgattgctc ttgccggcta tatgaggctg atcggtgata 632521 cgctccttca agcatatggg ggaaaaatca ttaacattca cccatcgctt cttccggcgt 632581 ttcctggaat cgacgcagtc ggacaggcgt tccgggcggg tgtgaaggtg gccggaatca 632641 ccgtgcatta tgtcgatgaa ggaatggata caggtccgat catcgctcaa aaggcaatcg 632701 aaattgatga acatgataca ttggaaacaa tcgaacagcg aattcacaag cttgagcata 632761 aatggtatcc gagtgtgatt aaacagctat taggattaaa taacagaggt gaaaaggcat 632821 gaccattaaa cgtgcattaa tcagtgtttc agataaaaca aatctcgttc ctttcgtaaa 632881 agaactgaca gagcttggcg ttgaagtcat ctccacaggc ggaacgaaaa agcttcttca 632941 agaaaacggt gtggatgtga tcggaatttc tgaagtgaca ggctttcctg aaattatgga 633001 cggccggtta aaaaccctac acccgaatat tcacggcggc cttctggcgg ttcgcggcaa 633061 tgaagagcat atggcgcaga tcaatgaaca cgggattcag ccgattgacc tcgttgtcgt 633121 caacctctat ccatttaaag aaacgatttc taaagaagac gtcacgtatg aagaagcgat 633181 cgaaaatatc gacatcggcg gacctggcat gctgcgcgcg gcatcaaaga accatcagga 633241 tgtcacggtt atcgtcgatc cggccgatta cagcccagtg ctaaatcaaa tcaaagaaga 633301 aggcagcgta tctcttcaga aaaaacgcga gctcgcggca aaagtattcc gtcatactgc 633361 ggcatatgat gcactgatcg ctgactatct gacaaatgtt gtcggtgaaa aagaaccaga 633421 gcaattcact gtgacatttg agaaaaaaca atcgcttcgc tatggagaaa acccgcatca 633481 ggaagcaact ttctatcaaa cagctcttcc tgtcaaaggc tccattgcgc aagcagaaca 633541 gcttcacgga aaagagcttt cttacaacaa cattaaagac gcggatgctg cagttcaaat 633601 cgttcgtgaa ttcactgaac cggctgctgt tgctgtgaag catatgaacc cgtgcggcgt 633661 gggaacagga aaaacgatcg cagaagcgtt tgacagagcg tttgaagcgg ataaaacatc 633721 tatcttcggc ggcattatcg cgctgaaccg tgaagtggac aaggcaactg ccgaagcgct 633781 tcacaacatt ttcttagaaa tcatcattgc gccttcattc agccaagaag cgctcgacgt 633841 cctgactgcg aagaaaaatc tccgtctgct gacgcttgac gtatccgccg ctgttcaaaa 633901 ggaaaaacag ctgacatccg ttcaaggcgg gctgctgatt caagatttag atatgcacgg 633961 cttcgatgat gctgagatta gcattccgac aaaaagagag ccgaacgagc aagagtggga 634021 agacttgaag cttgcttgga aagtcgtgaa gcatgtgaaa tcaaatgcga ttgttctcgc 634081 gaaggacaac atgacagtcg gcgtgggagc aggccaaatg aaccgcgtcg gatcggcaaa 634141 aatcgcaatc gagcaagcag gggaaaaagc gaagggcagc gcgctcggtt cggatgcata 634201 tttcccaatg ccagatactg tcgaagaagc ggcaaaagcg ggcgttacag ccatcattca 634261 gccaggcgga tcgatccgag atgaggattc catcaaaaaa gcggatgaat acggcattgc 634321 catggtattc accggcatca gacacttcaa acattaaggg gatgaaaacg acgtgaatgt 634381 attaattatc ggtaaaggcg gaagagaaca tacgctggcg tggaaggcag cgcaaagcag 634441 cctcgtcgag aatgtatttg ccgctcccgg aaatgacggc atggcagctt ccgctcagct 634501 tgtaaacatt gaggaaagcg accacgcagg gcttgtctca tttgcaaaac aaaatcaggt 634561 cggcctgacc attgtcggcc ctgaggttcc tttaattgaa ggtctggtgg atgaattcga 634621 aaaagcgggc ttacatgtgt tcggtccgtc aaaagctgcg gcgatcatcg aaggaagcaa 634681 acagttcgct aaggatttaa tgaagaaata cgacattccg accgcagaat acgagacgtt 634741 tacatccttt gatgaggcga aggcatatgt gcaggaaaaa ggtgctccga ttgtgataaa 634801 agcagatgga cttgcagctg gaaaaggcgt tactgtggct atgacagagg aagaagcaat 634861 tgcgtgcttg catgactttc ttgaagatga aaagttcggt gatgcgagcg cgtccgttgt 634921 cattgaagaa tatctttctg gtgaagaatt ttctctaatg gcctttgtca aaggggaaaa 634981 ggtgtatccg atggtgattg cccaggatca caagcgggcg tttgacggag acaaaggccc 635041 gaatacaggc ggcatgggcg cctactcgcc agttccgcaa atttcggaag aaacggtccg 635101 ccatgctgta gaaacgatcg ttaagccggc tgcaaaagca atggtacaag aaggccgttc 635161 cttcactggc gttttgtacg ctggattgat gcttactgaa aacggctcga aggtcattga 635221 atttaatgcc cgtttcggcg atccggaaac acaggtcgtg cttccgcgca tggaatctga 635281 tctggtacag gtgcttcttg atcttttaga tgataaggaa gttgacttaa gatggaagga 635341 taccgcggca gtgagtgttg tgcttgcatc agaagggtat ccggaaagct atgcaaaagg 635401 cacgccgatc ggcagccttg cagcagaaac tgagcaggtc gtggtcttcc atgccggaac 635461 gaaagcagaa ggtggagagt tcgttacaaa cggggggcgc gtcgccaatg tgacggcttt 635521 tgatgaaacg tttgaagcgg ctagagaccg agtgtacaaa gcggttgatg aaattttcaa 635581 accgggactc tttttcagaa aagacattgg ggcacgcgct ttaaaggctg cccaaaaata 635641 agtgaggaaa acccgcagaa tagctgcggg ttttttgtta tcaaaaagcg ggatggcagc 635701 tagaagaaga aagcacaacg agcgtggttg gttttccatg ggccatcgag gtgtcaataa 635761 aatcctcaag cgtatgtacc gattcagtca cgacctttgt cacatagctg tacatccccg 635821 tgatgcggtg gttttctgct acatcaggat gcgatgttgc aaaggcggcg tagtgcttgc 635881 agcttttcgg ctccatgaga ataaaagcgg tgacatgctt gtttagtttt tcgtaacaga 635941 tattcgcgct gtagccggta atcactcctt tgtcttccag cttcctgaca cgctccgccg 636001 cgcttggcga gctgagtccg acaagctttc ccagctcaac catcgttaat ctgccgtttc 636061 gctgcaaatg cgagagaatc tgaaggtctg tatcgtccat ttgtctggct cctttacata 636121 tttaggcgaa tgaatgaaaa ttcctttgat cgtaaggtaa tgctgttgat ttaacttcat 636181 tgtagcatat ggatgccgtc ttattttttc tataataaag ccatcaatca gagagggggc 636241 atcatgttgc cagaattgca gcgctctatt acttggatac aagggacggc gttaacgatt 636301 ggggcggttt taggatgcgg gatattaatc ctgccgtctg tcaccgcgga cacggccggc 636361 cccgcttctt tatttgtttg ggtgttcatg tccttcttat ccttttttct tgtcggcacg 636421 ctggcccggc ttgtgaaaat agcgcctagc gcgggaggaa tcacggctta tgtgcagctg 636481 gcctttcaga aaaaagccgg ggctattttg ggctggatca tgttagggtc cgttccgatc 636541 ggcgttccca tcatcgcttt gactggcgcg cattacgtca gttacatcac agaggcggcc 636601 gattggcaga ttacattgat tgctggttgc atgctggcta tatctatttt gcttcatatg 636661 agagggattc aactatcagc aaacattagt acactcgtta tatgtgtcat cgtatttctg 636721 cttgtcactt ctattgctgt gtcattgcca cacgtcacga tagcagaatt caagccgttt 636781 cttccgcatg gctggtctgc cgctggatct gtttctgtta tgattttttt ctcttttgta 636841 ggctgggaaa tgattacccc gttggctgag gaatttcatc gtcctgaaaa agatgtcccg 636901 ctcagcttgt ttttggcagc gtcttgtgtg gcggggctgt atatcatgct gtcatttgtg 636961 accgtgggta ctcattcata tggagagaat ggagaaattg catcgcttgc catgctcatt 637021 tcaaaaggag caggagaaag cggtgtatat gtcacggtat gtttagcgct gtttattaca 637081 ttcgccacca tccatgccaa tattgccggt ttttcaagaa tggtgtacgc attggcgaga 637141 gaggggcaca tacccgtatt ttttggaaaa ctcagtgcga caaaacgtac gcctattcgc 637201 gttttgacag cgatggccgc agtgtttggc ttagtgcttg cagcgcatgg tctgtttcaa 637261 atcgatttga cgactctgtt gaaagggccg agcgcggctt ttatcgcatc ttacatatgt 637321 acaatggcgg cagcactgaa actgctgggc aggagagata taggctggtg gatggcgctc 637381 ggggcatttg tggcgtgcgc ggtgatttat tcattcagcg gctgggcact gctttatccg 637441 gcagtgctgg cagctgcagg atatttctat atgaaaacaa agggtgggca taaaaaaaag 637501 cttgatcacg ttttgtgatc aagcttttcc atttatccgt tttgatgctc gttatttcca 637561 gaatcgctgt gttgaaacat gtaggtcaca ggacagaagc gcaagattcc cgaacccgct 637621 ttcatggccc ccataaagat gtaaaagaga tgcattctgc accaaggttt tttcgtaaac 637681 tttgcactgg cggctgacat aatcgtcaat ccgcaggcga ttctgaacac ggcattgatg 637741 agactgatgt ttggcttcaa ggaaatccgc tccttttact taaaaaagtt ttttaatcga 637801 accttcaaaa atttgtaacg tttttatcgt gcgtgatgag gaaggatgtg ataccatgag 637861 tctaatacat gtaaaggaga gtatgtgaat gtccgaacgc acctttaact ggaaaaacaa 637921 agacatcagg gcacaggttg atgttgtaga ctcaaagctg cttccaacgc tccttttacg 637981 gaatgctctc gtcttaaatc catatgtaaa acaatggctg aaaaaaaaca tttggattta 638041 tcaggaccgc attgtttatg tgggtcatga acttccgaat agagccgaag aaattcatac 638101 gattgattgt gaaggaaaat acattgtgcc aggttatatt gaaccgcacg cacatccttt 638161 tcaaatatat aatccccaaa cactggcgga atatgtgtct caatacggaa caacgacatt 638221 cgtgaatgat aacttatttt tgcttttgca aagcggaaaa aagaaagcgc ttacgatttt 638281 gaatgaactc aaaaagcagc ctgtccagta tttttggtgg tcacgctatg acctccagac 638341 cgaggttctg aacgaggacc acgtccttcc atttgacgtc agaaaacagt ggattgaaca 638401 tccggatgtg attcaaggcg gagaaatgac cggatggcct cgcctggtag atggtgatga 638461 tttaatgctc cactgtatgc aagctacaaa gaaacagaga aaacgtattg aagggcattt 638521 tcccggcgct tctgataaaa cgcttacaaa aatgaagctg ttcggtgcgg attgtgatca 638581 tgaagcgatg acaggtgatg aagtgatgag aaggctggaa ctgggctatt atgtttccct 638641 tcggaactct tccattcgcc ccgatgtaag aaaaatcttg caagagctgc atgagaaggg 638701 cttccgctat tatgaccact tcttttacac gacagatggc gcaaccccga atttctataa 638761 aggcggcatg acaaacgagc tgattcgcat tgcgttagaa gaaggcgtac ctgcaatcga 638821 cgcctacaat atggcatcat ttaatatcgc aaagtattac caaatggatg attatttagg 638881 agttgtcgga ccgggcagac tggcatcgct aaacatactg gaagatccgt taaatccgaa 638941 tccagtgact gttctgtcaa aagggaccat tctgcgtgaa aacggctgtg atttgaaggc 639001 gtttacaaag acggactggc acaaaggcgg tcttgtcccg cttgagcttt catatgatat 639061 gacgatggat gacttgcagt tttctatgcc gatgggcgtg aaaatgcgga atgcggttat 639121 tatggagcca tatatgattg agatcgacaa ttcgatggaa cagctctcgt ttgaccatga 639181 tgaaagttat ttgacgatgc tcgacagaca cgggaaatgg cgcgtcaata cgatgataaa 639241 agggtttgcc tcaagcgtgc agggatttgt aagctccttt acgacgacgg gcgacattgt 639301 cgcgattgga aaaaataaag cggatatgct gctcgctttc gcccgcatga aagaaatcgg 639361 aggaggaatt gttttagcgg agaacggaaa cattctgcat gaaatcccgc ttgcgctgtg 639421 cggctgcgcc tcttcggaag cgtatgaaga cgtgcttgag aaggaacaaa agctgagaga 639481 tcttttgact gaaagaggct atgagttttg cgatcctatc tatacgctgc tctttttgca 639541 aagtacgcac cttccgtata tacgcattac gccaagagga atattcgacg tcatgaaaaa 639601 aactgtactc tttccatcga taatgcgtta aaatataaaa gagcagggag ccgacatatg 639661 aaaaaatgga tgacagtttg cgcgctgtgt ttcgtgtttt ttctgctggt atcctgccag 639721 cagaaggatg ctgtcccgga tactgcaaag aagctgaaag ctcctttaac ggggctaaag 639781 actgaacaga aagtgactga acgccgccct gttgctgttg tggtgaacaa tcacccgaag 639841 gcgaggccgc agtcgggtct gtctaaagcc gacattgtca tagaagcgct agccgaaggg 639901 caaatcacaa gatttctggc cattttccaa agccagatgc ctgaaactgt cggacctgtg 639961 cggagcgcgc gggaatattt cgtcactctc agcaatggct ttgacagcat atttgtccat 640021 cacggctgga gtcccggcgc caaaaagcag ctggaatccg gagctgccga ttatatgaac 640081 ggattggatt ttgacggaag cttattttgg agagctgatt tcagcaaacc gccccacaat 640141 tcctatacgt cttatgatta cataaaaaag gcggcagaac aaaagggtta taagctgaag 640201 caggaaacaa atccgctgct gtttcaaaca tcagatgcaa aacctgcaaa tgaatcttac 640261 aatgttcggg tagattatgg aacaaataac gttacaaatc ttgtcgaata caactatgat 640321 aaaaaagctg aattttatac aagaagctct gatggtgtca taacgacaga ccgggaaacc 640381 ggaaagccgg ttgcaatgca aaatattttc attgttgaag ccagccatca tattattgat 640441 caagatggaa ggcgggacat cgacttggaa tcaggaggaa aaggtctgtt gtttcagcac 640501 ggaaacgtca ttgaaacaga ctggaaacaa gtgaatggca gaattgtgcc ggtaaaagac 640561 ggcaagtggc ttccgtttgt gccaggaaag acttggatca atatcgtacc tgatcttgat 640621 gcggcttcca ttagtaaagg agaaggtgtg taacgatgca aatcgataaa ttacgcggca 640681 aagagctgga ccagttattt aactcgatct tatcgctgaa agacctggag gaatgttacc 640741 gattcttcga tgatctatgc acaattaacg aaattcaatc gctggctcag cgccttgaag 640801 tggcgcgcat gcttcgcgaa ggaaacacgt atcataagat tgaaacagaa acaggcgctt 640861 ccacggctac gatttcccgt gtgaaacgct gcttaaatta cggaaatgac gcttatgaaa 640921 tggcgcttga ccgtgtgaag gagacggaaa cagagtcttc ttccaaataa aaaaccgccc 640981 tgccgtctgg caagggcggt ttctttatga aacaaattga tggatcaggt tgtcgatatt 641041 gatgatactg ccatcctctt tccgatagac aacatgctcc ttggaaaaat gaatcggcga 641101 attaatccct gctgcggctg caaggttaaa tagtccctcg cgcaatgaaa taacgtagtt 641161 gcagacacga tgctgttttt cctcaacgct cagtgctttt tgcaatttcg gatctgtcgt 641221 cgccacacct gccggacagg tgttggtgtg gcagacgaga gcgcggatgc agccaacgga 641281 aaacatcatg ccgcgtgcga tgttaacaaa gtcagcgccg agggctaagg cgaccgcgat 641341 tttatcagga gtcaggagct ttccggaagc aaagattttc agctggctgc gcaagccgta 641401 ctgtttaaga agcgtgtcca caataggcag cgctgtcata atcggaaggc cgactgtatc 641461 cgcgagctcg taaaaggaag ctccggtacc gccttcactt ccgtcgatcg tgataaaatc 641521 cggatgcttt ccgcttttct gcatatgaga gaaaagctca tgcaattctt caggatgccc 641581 tgcgaccagt ttgatgccga ctggcttttg tccgacatct ctaagttttt caataaagtc 641641 gagcatttca ggagggtttg agaattcata aaagcggttc gggctgtcaa tcgactttcc 641701 aggttcgaca ttccgaatgt ctgccacttc ctctgatact ttggcgccgt ccacatggcc 641761 gccgcgggtt ttcgctcctt gtgccagctt tagctcaaac gctttaatct ggtcaatcct 641821 gctttttctt ttaaattcct cccacgaaaa ttccccgttt cttttgcgca cgccgaatag 641881 gcccggtccg atttggcaaa tgatatcggc gccgcccttt aagtgatatt cagacaatcc 641941 cccttcacct gtattcatcc aggtgccgcc tgccagatgg agcccttttg agagcgccgt 642001 aacagcccgt tctccaagag aaccgtagct catggcagac tggccgacta agcccttcac 642061 ataaaatggc ttctcgcatg tatgctcgcc aatcacctgt acatcatcag gatggagaaa 642121 atacgggtct gccttgatat gttcggcatg ctccttgcgt ttgaacagat tgtcagcatc 642181 cattttatag atttgggttt caatttttgg cgtttgattt acatgcattt cttccctttg 642241 ttttggaaac atagcgttac ggatataata gccaggttta tcaaaatctc ttacagatcc 642301 aaagcccatc attctgcttt tgtatttgcc ggagatgacg gtttgctcat attcctttcg 642361 tgaaaatggc tgctcttcat tgtcattgct gtataaatac tgtctgagct ccggcccgat 642421 tttttcaagg atataccgaa accttccgat gacgggatag ttgcgaagaa ttgagtgctc 642481 ctgctgtttt tcatccttta tgtagatcca ggcaaacaag acgatcggga tagcgatgat 642541 cccaatgata aatgcgatga gtgctattat gatggtttcc atctctcagc ctcccttttt 642601 atgtaaccat ttccacagta gaacactttc caaacaatag cagaaggaat ctggtgaaaa 642661 atgtgtgctc ctgccgatac aggactcacc atgcaggtac tgccatatgc tctctttttt 642721 tatgaaaaaa gaatcaaaac acctttttca gtgaataacg agattaacgg ctttttccgt 642781 ttttccgcgc tatgtgaatt tgttataatg tttaaatggt aacaaacgaa tggaggaacg 642841 tatgacgtgt acgatgtaac ggagtggaag catgtcttta aactcgatcc aaataaagat 642901 ttgcctgacg aacagctgga gattctttgc gaatcaggaa cggatgcggt cattatcgga 642961 ggaagcgatg gtgtgacaga ggataatgtc ctgcggatga tgtctaaggt aagacggttt 643021 ttggtgccgt gtgtcctaga ggtatcagcg attgaagcga ttgttcccgg ctttgactta 643081 tattttattc cgagtgtatt aaacagcaaa aacgcggatt ggattgtcgg aatgcaccag 643141 aaagccatga aggaatacgg agaactgatg tctatggaag aaatcgtggc ggagggctac 643201 tgcatcgcaa atccagattg caaagccgcg gcactgactg aagcggacgc cgatctgaat 643261 atggatgata ttgtcgccta tgcgcgtgtg tcggagctgc tgcaactgcc gattttttat 643321 ttagaataca gcggcgtgct tggagacata gaagctgtca agaaaacgaa ggctgtattg 643381 gaaacgtcca ccttgtttta cggcggcggc atcaaggatg cggaaacggc caagcagtac 643441 gcagagcatg cggacgtgat cgttgtaggc aatgcggtgt atgaagattt tgacagggct 643501 ttgaaaacag tagcggctgt gaaaggcgag tagtaaattg tacggatttg gtttatgata 643561 gaacgtatgt tttgtatagg cgggtgaaca aattttgaat tatattagca atcaattact 643621 aagcggttta aaccccgttc agcaggaagc agtcaaaaca acggacgggc ctcttttgct 643681 gatggcggga gcgggtagcg gaaagacgcg tgtcctgacc catagaattg cttatttaat 643741 ggcagaaaag catgtggcgc cgtggaacat tctggcgatc acatttacaa ataaagcggc 643801 acgcgaaatg aaagaacgtg tggaaagcat cctcggaccc ggcgcggacg atatctggat 643861 ctccacattc cacagcatgt gcgtgcggat cttgcgcaga gatatcgacc ggattgggat 643921 caaccgaaat ttctccatcc ttgatacggc tgaccagctt tcagtgatca aggggatttt 643981 gaaggagcgc aatcttgatc cgaagaagtt tgacccgaga agcatcctcg gcacgatcag 644041 cagtgcaaaa aacgaattga ccgaaccgga ggaattctct aaagttgctg gcggctacta 644101 cgatcaggtg gtcagcgatg tatatgctga ttatcagaag aagctattga aaaaccagtc 644161 gctcgatttc gacgatttaa ttatgacgac gattaaactg tttgacagag tgcctgaagt 644221 gcttgaattt tatcagcgca aattccagta catccacgtt gatgagtatc aggatacgaa 644281 cagggcacaa tacatgctcg ttaagcagct tgccgagcgt ttccagaacc tttgcgttgt 644341 gggggattct gatcagtcaa tctacagatg gcgcggcgcg gatatcacca acattctttc 644401 atttgaaaaa gattatccga atgcaagcgt gattttgcta gaacaaaact atcgttcaac 644461 gaaacggatt ttgcgcgcgg ctaacgaggt cattaaaaac aactctaacc gcaaaccgaa 644521 aaatttgtgg acggaaaatg atgaaggcat caagatttcc tattatcgcg gtgataatga 644581 gttcggtgaa ggacagtttg tggccggcaa aattcatcag cttcacagca caggcaagcg 644641 gaagctgtcg gatatcgcca tattataccg gacaaacgcg cagtcccgtg tgattgagga 644701 aacgcttctc aaagcgggct tgaactataa cattgtcggc ggcacaaagt tctatgacag 644761 aaaagaaatt aaagacattc ttgcgtacct gcgcctcgta tccaatccgg atgacgatat 644821 cagtttcacg cgcattgtca atgtgccgaa gcgcggagtc ggcgcgacat cacttgaaaa 644881 aatcgcttcg tatgcggcca taaacggctt gtcctttttc caagcgattc agcaggttga 644941 ttttatcggc gtcagtgcca aagcggcaaa cgcgcttgac agctttagac agatgattga 645001 aaacctgacc aatatgcagg attacttatc cattacagag ctgacagaag aaattcttga 645061 taagacggaa tacagagaaa tgctgaaggc tgagaaatcg atcgaagccc aaagccgttt 645121 agaaaatatc gacgagttcc tgtctgttac gaaaaacttt gaacagaaaa gtgaagacaa 645181 gacactcgtt gcgttcctga cagacttggc attgatcgca gatattgatc agctcgatca 645241 gaaggaggaa gagtcaggcg gcaaggatgc gatcaccctg atgacactgc acgccgcgaa 645301 aggactggag tttccggttg ttttcttgat ggggcttgaa gaaggcgtct tcccgcatag 645361 ccgttcactc atggaggaag cggaaatgga agaagaacgc cgccttgcgt acgttgggat 645421 tacaagggcg gaacaggagc tttatctgac caatgctaaa atgcgcacct tgtttggccg 645481 gacaaatatg aacccggaat ctcgcttcat tgctgaaata ccggatgatt tattggaaaa 645541 cctaaatgag aaaaaagaaa caagagcgac gtctgcgaga aaaatgcagc cgagacgcgg 645601 ccctgtttca cgcccggtat cctacgccag caaaacaggc ggcgacacct tgaactgggc 645661 agtcggagat aaggcgggcc ataaaaaatg gggaacagga actgtcgtca gcgtgaaagg 645721 cgaaggagaa gggacagagc ttgatattgc cttcccgagc cctgtcggcg tgaaacgcct 645781 gttagcagca tttgctccta ttgaaaagca gtaattgaag aggaaaggaa gaagcagatg 645841 gacaaagaaa cagcgaagca gcgggcagaa gaactgcgcc gcaccatcaa caagtatagc 645901 tatgaatatt acaccttaga tgaaccgagc gtcccagatg ccgaatacga cagattgatg 645961 caggagctga tcgcgatcga ggaggagcac ccagacctca gaacgcctga ctctcctacg 646021 cagcgcgtcg gcggagccgt gcttgaagcg tttcagaaag tcacccacgg cacaccgatg 646081 ctcagtctgg gcaacgcctt taatgctgat gatcttcgtg atttcgaccg ccgtgtgcgc 646141 cagtccgtcg gcgacgatgt ggcgtataat gtggagctga aaatagacgg tcttgctgtt 646201 tctctccgtt atgaagacgg ctattttgtc agaggggcca caagaggtga cgggacgacg 646261 ggagaggata tcacggagaa tctgaagacg atccgcaata tcccccttaa aatgaaccgt 646321 gagctgtcga tcgaagtgcg cggcgaggcg tatatgccga agcgttcgtt tgaagcactc 646381 aatgaggaac ggattaaaaa tgaggaagaa ccgttcgcca atccgcgaaa tgccgcggcg 646441 ggatctctca gacagctcga tccgaaaatt gcagcgaaac gaaacctcga tatcttcgtc 646501 tacagtatag cggagcttga cgagatgggt gtagagacgc aaagccaagg gcttgatttt 646561 ctcgacgaac tcggatttaa aacgaatcag gaacgaaaaa aatgcggcag catagaagaa 646621 gtcattacgc tgatcgatga gcttcaggcg aagcgcgcgg acctgccgta cgaaatagac 646681 ggcattgtca ttaaagtcga ttctctcgat caacaggagg agctcggttt tacggcgaaa 646741 agcccgcgct gggccatcgc gtataagttt cctgctgaag aggtcgtgac gaagcttctc 646801 gatatcgaat taaatgtcgg cagaacgggt gtgattacgc cgactgcgat tcttgagccg 646861 gtaaaagttg ccggcacaac ggtctcaaga gcatcccttc ataacgaaga tttaattaaa 646921 gagaaggaca ttcggatttt ggataaggtt gtcgtcaaaa aagcgggcga tatcatcccg 646981 gaagttgtga atgtcctcgt tgaccagcgc acaggagaag aaaaggaatt cagcatgccg 647041 acggaatgtc ctgaatgcgg cagtgaactc gtccggatcg aaggagaagt ggcgcttcgc 647101 tgcattaacc ctgaatgtcc ggcgcaaatc cgggaagggc ttatccattt cgtttcccgg 647161 aatgccatga acattgatgg gctcggcgaa cgagtgatca cacagctgtt tgaggaaaac 647221 cttgtccgca atgtggcaga tttatataag ctgacgaagg aacgagtcat ccagctcgag 647281 cgcatgggcg aaaagtccac tgaaaacctg atcagctcca tccaaaaatc aaaagaaaat 647341 tcgttagagc gcctgctgtt tgggcttggc atccgtttta tcggatcaaa ggccgcaaag 647401 acgcttgcca tgcattttga aagcttggag aacctgaaaa aagcctctaa agaggaactt 647461 ctcgcggtag atgaaatcgg tgaaaaaatg gctgatgctg tgatcaccta ttttcataaa 647521 gaagaaatgc ttgaactctt gaatgaactt caggagctgg gcgtaaacac gctctacaaa 647581 ggcccgaaaa aagtaaaagc agaggacagc gactcttact ttgctggtaa aacaattgtt 647641 ctgacaggaa agctggaaga gctgtcaaga aacgaagcca aagcgcaaat cgaagcgctg 647701 ggcggaaagc tgactggaag cgtcagcaaa aacacagact tagtcatcgc cggagaagcg 647761 gcgggaagca agctgacaaa agcacaagag ctgaacattg aagtgtggaa tgaagaacag 647821 ttaatgggag agctaaagaa ataagaggag tgttttctat tgaaaaagac gttggcattg 647881 gcggcaacgg cggcagtatt aatgctgtct gcctgctcgt caggtttcgg gggggagaag 647941 gaggaagaga ttacgcaaaa gacggcgaaa tcgtcagaaa aagcgattgt cccgaaatat 648001 aatatctctg actcctatta caaaatggtg ctgccgttta aggcaggcaa agcgcgcggc 648061 ttaacaacgg aacagctgaa tacaaggctg gacattgacg aatttgaaac agggctgatg 648121 cgccttgccc aagattcttt ctcaactgac gattatctgt tccaagaagg acaatattta 648181 gatgaggata cagtattaag ctggctggca cggaaaaaaa cgggctctga tttgaaaaaa 648241 gccgaaaaag aagataagaa cttcaaaaat gaaggcttga acccggcgct cccgagttct 648301 ggttcaacag aagaaaagaa cgaaagcagc ccaatttatt tagcatccat gcttgagcac 648361 gattatttag tcagaaaaga caagaattct atccagcttg gcggcgtcat gatcggactg 648421 gcgttaaact cagtgtatta ctatcgtgaa aaaactggcg acccgcaaaa agaagtggag 648481 attaaagaca gcacgcttcg ccagcaggga gaaaaaattg cacaggaggt tattaaccgc 648541 ctccgcaaaa aagataactt gaagaatgtg ccgattaccg tggcgctcta caagcaggcg 648601 tcaaaaacat cgattgtgcc ggggaacttc atcgccaaaa cagaggtcaa agcaggctct 648661 actgatatct caaattggga tgacatcaat gaaaaatatg tattctatcc ggcggataca 648721 accacagcag aaaagtaccc ggatgacacc gaggtcttta agcggttcaa aaactcaatt 648781 gaagaatatt tcccgaacta tacaggcgtt gtcggtacag cgctgtatga aaatgatgaa 648841 atgaagaaaa tgaagattga cataccaatg caattctacg gaaaaagtga agttgtcgcg 648901 tttacccagt tcttaacggg tgaagtgatg gactactact ctaagagctc agttgatgtc 648961 gaagtcaata tcacgtcctc agacggacag gaagcggtca ttatccgcaa tgccggagat 649021 aaagagccga ctgttcacat ttatgactga tagaaaaccc ttgtgccata ttggcacaag 649081 ggtttttatg ttacaattaa caggaaaagg gaaaatattt tcacttctgc cgaaacacaa 649141 atcaagggga ggtatgttga tgctggaaat cgtgtgaaaa caatcattat caaatctata 649201 gcaatgaaag gatgttagac gtgcataaag atatcaaaaa aatatttcat gaagagcagg 649261 ttttggcaga agctgcagcg agatacggtt tctcaaaaga tcaggtgcgt tttctggctg 649321 atgcggaaaa ctatgtatat gaatgtatga aagacaatca accttatatt ttaaagatta 649381 cccatacgat tcggagatct tctgattata tgatgggaga gatggaatgg ctccgtcacc 649441 ttgcaatagg gggaatttca gtagccaaac cgctcccgtc gctgaacgga aaagacgtag 649501 aagcagtgcc ggacggaaac ggcgggtcat ttttattgag agtgtatgag aaagcgccgg 649561 ggcaaaaagt ggatgaatcg gactggaatg aaacgctatt ttatgagctt ggcagataca 649621 caggcagcat gcacagcctg acaaaaagct acaaattgag caatcccgct ttcaaaagac 649681 aggaatggga tgaagaggag caattaaagc tgagaaaata tgtgcctgaa gatcagataa 649741 aggtgtttca gcaagccgat tctttgatga atgaactgcg gaggctcccg aaaagccagg 649801 acaactacgg cttggtgcat gcggatctgc accatggcaa ttttaactgg gatcatggca 649861 aaatcacggc atttgatttt gatgatatcg gctacaactg gtttgttaac gatattagca 649921 ttcttctcta caatgtcctg tggtatcctg ttgtgccata tgatgataaa gctgcgttta 649981 cagaagaatt tatgacgcat tttatgaaag ggtactggga ggaaaatgag cttgaccctg 650041 catggctgat gataatacct gatttcctcc gccttcgcca tatgctgatt tacggattgc 650101 tgcatcagat gtttgacctt aacacaatag gagaagagga aaaagaaatg ctggccggtt 650161 tcagaagaga tatagagaat ggcacgccga ttacagcatt tgatttttca gcactggtgt 650221 agatagaaaa agccaatggg attccagtcc cattggcttt tataatgtat cacacttcac 650281 gccgactacg ccttcaatgg ctttaatgtc atagtagaca tcggtcgtgt atctgttttt 650341 atggacgcgg accttcactt ccataattgg aaaatccttt tcgcctaggt cgtcgatccg 650401 aacggagtgt gctttgatat ctcttctttt catttctttt aaaatctctg tcattttgtc 650461 tttatcagaa agtgacattc tgatgcggat gtctttttcc tgcaggcggt cggggccgat 650521 ttttctgacc acccatggga gaaattccac actgatcagg atgaacagaa gactggcaaa 650581 cgcttcttta taaaaaccgg ctcccgtagc aagcccgagc cccgctgccc cccagatcat 650641 ggccgatgtc gtcaggccgg aaatgacatc attgcttttt cgcaggatga caccggcgcc 650701 gataaacccg acgccggaga tgatttgtgc cggcagacga agcggatcca tcatgatgcg 650761 gtagtattta gggaaatgat atgccgcatt aatactgacg atcgtcagca tgcatgagct 650821 gactgcgatg acaatacagg tttttaatcc gagcggctta ttttttaatt cgcgttcaag 650881 cccgatgacc atgccaatca atgtggcaat gcccaatttc aataaaatat caggatcaat 650941 ataccagctc aacagcaaac ttcccccttc tctatggtgt ttttaaataa atatgatttt 651001 ctcacagtat ttatagcaaa acaagagcac aaaagccacc aagctgcgct tgatggctta 651061 ttgcttactt tttgcgtttt aacagctttt ccatgacacc gaataatcgg taagaggctt 651121 ttgcaggacg ttttgtgatc atgctgacaa tgatgccggc aatcatactg agaataaacc 651181 cagggatgat ttcgtacaca ccggttgatt ttgccaggcc ggttgtaatc cagatcaaca 651241 cggtcgcagc cccgacaatc atggcagcaa gcgcgcccca ttcgttcatt cgtttccaat 651301 acagactgag cagaatcgca ggcccgaaag ctgaaccgaa gccggcccaa gcgtatccga 651361 ccaaatcaag aatggtgctg ttcgggttca atgacaagag taccgcgata acggcaatga 651421 ctaagacgga caatcgcccg atcatgacca attctttatc agaagctttt cgtctgaaaa 651481 atgaccggta taaatcctct gttacagcac ttgctgtgac caagagctgt gaggaaatcg 651541 aactcatgat ggcagccaaa atagctgaca ataagaaccc tgtaattaat gggtggaaca 651601 agattttaga gaagataatg aaaatcatct ccggatcttt tacagcaact ccgaatttat 651661 gggcgtatgc aacaccgatt aaacccgtca gcacggaacc tagaactgta atgatcatcc 651721 agctcatgcc gattcggcgt gcaggtttta aatctttaat gtctttaatg gccataaatc 651781 ggacgatgat atgaggctgg ccgtagtagc ccaaccccca ggctaaatag gaaataatgc 651841 taatgacgct cgcgccttta aaaatatcca ataaatgtgg attaacagcg tcgatttcat 651901 ggaaagtcgg agcaacgccg cccacatggg taaaagcaac gatcggcaca agcactagtg 651961 ctgcaaacat gatcgcaccc tgcacgaagt cagtcagact gacagcaagg aaaccgccaa 652021 acagtgtgta taacacgaca actgcggtgg tcagaaacag gcctaatttg taatccgcac 652081 caaaagcaga ttcaaacagc cgtccgccag ataccatacc ggaagaggta tacaatgtga 652141 aaaagatcat gatgatcaat gcagatacga ttttcagcag tgatgaagaa tgctggaatc 652201 gtttatcaaa gaaatcagga attgtaatcg catcatctgc cgcttctgta taagcacgca 652261 gccttggagc cagcagcaag taatttgagt acgccccgat tgtaagacct aaagcaagcc 652321 ataaggtgga cagccctgtc gcaaacatcg cgccgggaac acccatcagc atccatccgc 652381 tcatatcggc cgcgccggca gacaaagcag taacgaatgg tccgaggcct cttcctccaa 652441 gcatgtaatc attgatgtca gtggttttct tgaatgcata ccagccgatt aacagcatgg 652501 caataaagta aattcctaaa gatataataa tttcaatact cacgttttac cctctcttca 652561 tttctaataa tgttgcatca cctctcaaat tgatggtgcc agttaagcag cctggcgtaa 652621 gtgcaaaaca aaagaaattc ttttgcgggt gcacttggta acttaaccta acaaagtatt 652681 cccggccatt caagcgatga aacattgatc ataagctgga aataccgttg caaacctaga 652741 agggaataaa gaataaaacg ctttcaaaaa ataattaaag taaaaatatt cagaaaaata 652801 tttcgtttct ccttctcctc attttagtat aaaatatata gggtattgtt tcgaaaacac 652861 aggcctgtct caaggcgttt tgttgcttta aagggcttgt ttttgatatg atcagtatta 652921 tatgacttaa cggagaaata tgtggaggtg gatcatatgt cacgaatttc aatagaagaa 652981 gtaaagcacg ttgcgcacct tgcaagactt gcgattactg aagaagaagc aaaaatgttc 653041 actgaacagc tcgacagtat catttcattt gccgaggagc ttaatgaggt taacacagac 653101 aatgtggagc ctacaactca cgtgctgaaa atgaaaaatg tcatgagaga agatgaagcg 653161 ggtaaaggtc ttccggttga ggatgtcatg aaaaatgcgc ctgaccataa agacggctat 653221 attcgtgtgc catcaattct ggactaaagg agggacacaa gaatgtcatt atttgatcat 653281 aaaatcacag aattaaaaca gctcatacat aaaaaagaga ttaagatttc tgatctggtt 653341 gatgaatctt ataaacgcat ccaagcggtt gatgataagg tacaagcctt tttggcatta 653401 gatgaagaaa gagcgcgcgc atacgcgaag gagcttgatg aggcggttga cggccgttct 653461 gagcacggtc ttcttttcgg tatgccgatc ggcgtaaaag ataatatcgt aacaaaaggg 653521 ctgcgcacaa catgctccag caaaattctc gaaaactttg atccgattta cgatgctact 653581 gtcgttcagc gccttcaaga cgctgaagcg gtcacaatcg gaaaactgaa catggacgaa 653641 ttcgccatgg ggtcatctac agaaaactca gcttacaagc tgacgaaaaa cccttggaac 653701 ctggatacag ttcccggcgg ttcaagcggc ggatctgcag ctgcggttgc tgcgggagaa 653761 gttccgtttt ctcttggatc tgacacaggc ggctccatcc gtcagccggc atctttctgc 653821 ggcgttgtcg gattaaaacc tacatacgga cgtgtatctc gttacggcct ggtcgcattt 653881 gcgtcttcat tggaccaaat cggaccgatt acacgtacgg ttgaggataa cgcgttttta 653941 cttcaagcga tttccggcgt agacaaaatg gactctacga gtgcaaatgt ggacgtgcct 654001 gattttcttt cttcattaac tggcgacatc aaaggactga aaatcgccgt tccgaaagaa 654061 taccttggtg aaggtgtcgg caaagaagcg agagaatctg tcttggcagc gctgaaagtc 654121 cttgaaggtc tcggcgctac atgggaagaa gtgtctcttc cgcacagtaa atacgcgctt 654181 gcgacatatt acctgctgtc atcttctgaa gcgtcagcga accttgcacg ctttgacggc 654241 atccgctacg gctaccgcac agacaacgcg gataacctga tcgaccttta caagcaaacg 654301 cgcgctgaag gtttcggaaa tgaagtcaaa cgccgcatca tgctcggaac gtttgcttta 654361 agctcaggct actacgatgc gtactacaaa aaagcgcaaa aagtgcgtac gttgattaag 654421 aaggatttcg aggacgtatt tgaaaaatat gatgttattg ttggaccgac tacaccgaca 654481 cctgcgttta aaatcggtga aaacacgaag gatccgctca caatgtacgc aaacgatatc 654541 ttaacgattc cggtcaacct tgccggcgta ccgggaatca gtgtgccatg cggattagca 654601 gacggacttc cgctcggcct gcaaatcatc ggaaaacact ttgatgaaag cactgtatac 654661 cgcgttgctc atgcatttga acaagcaaca gaccatcata aagcaaaacc tgaactgtaa 654721 ggggtgaaaa gaattgaact ttgaaacggt aatcggactt gaagtccacg ttgagttaaa 654781 aacaaaatca aaaattttct caagctctcc aacgccattc ggcgcggagg cgaatacgca 654841 gacaagcgtt attgacctcg gatatccggg cgtcctgcct gttctgaaca aagaagccgt 654901 tgaattcgca atgaaagccg ctatggcgct caactgtgag atcgcaacgg atacgaagtt 654961 tgaccgcaaa aactatttct atcctgacaa cccgaaagcg tatcagattt ctcaatttga 655021 taagccaatc ggcgaaaacg gctggatcga aattgaagtc ggcggcaaaa caaaacgcat 655081 cggcatcacg cgccttcatc ttgaagagga tgccggaaaa ctgacgcata cgggcgacgg 655141 ctattctctt gttgacttca accgtcaagg aacgccgctt gttgagatcg tatcagagcc 655201 ggacatccgc acgccggaag aagcgtacgc atatcttgaa aagctgaaat ccatcatcca 655261 atatacaggc gtttctgact gtaaaatgga agaaggctca cttcgctgtg acgccaatat 655321 ctctcttcgt ccgatcggcc aagaggaatt cggcacaaaa acagaattga aaaacttgaa 655381 ctcctttgcg tttgttcaaa aaggccttga gcatgaagaa aaacgccagg agcaggttct 655441 tctttccggc ggcgtcatcc agcaagaaac tcgccgttat gatgaagcaa cgaagaaaac 655501 cattcttatg cgtgtcaaag agggatctga cgactaccgt tacttcccag agccagatct 655561 agtcgagctc tacattgatg atgaatggaa ggaacgcgta aaagcaagca ttcctgagct 655621 tccggatgag cgccgcaagc gttatatcga agagcttggc ttgcctgcat atgacgcaat 655681 ggttctgacg ctgacaaaag aaatggctga tttcttcgaa gaaaccgttc aaaaaggcgc 655741 tgaagctaaa caagcgtcta actggctgat gggtgaagtg tcagcttacc taaacgcaga 655801 acaaaaagag cttgccgatg ttgccctgac acctgaaggc cttgccggca tgatcaaatt 655861 gattgaaaaa ggaaccattt cttctaagat cgcgaagaaa gtgtttaaag aattgattga 655921 aaaaggcggc gacgctgaga agattgtgaa agagaaaggc cttgttcaga tttctgacga 655981 aggcgtgctt ctgaagcttg tcactgaggc gcttgacaac aatcctcaat caatcgaaga 656041 ctttaaaaac ggaaaagacc gcgcgatcgg cttcctagtc ggacagatta tgaaagcgtc 656101 caaaggacaa gccaacccgc cgatggtcaa caaaattctg cttgaagaaa ttaaaaaacg 656161 ctaataaaaa agcagccctt agaggctgct ttttttatgg tcaaattgag ataaagacaa 656221 gatgagggcc cgaagccttt caacttcttt gtcgttggtt ccggccaaat tggacagcat 656281 gcctttaata atcggcttgc gcggtttatc ctgagtcaat tcttcctcga taacatcaag 656341 tgacacggtg atatcctcgg gcagcgtgct gttttctttc actttctgaa tgtcctcaag 656401 cagctggtct tttcccgcag gcatcgggtt aaaaatgtct tttgatacaa tcggattgag 656461 tgcagaacgg ctcagcccct gtacaagatc atccagtctc tcaataataa aggctgagat 656521 ttcttctgca tcgatattaa gctcaccgtt aaataccatc acgttcatat aggaatgcac 656581 aatgcctctt gccatgatgg acagatctgc gacataccgc tcgattcctt cgccatagga 656641 taccagcaag gcgttccggt acagcttatc cgtctccatg gttactttgt aaaagtattg 656701 cttgatttct tgattttccg gaatgatatt ttcggtaagc aaaagaacga taaaatcttt 656761 atgatcgcga aaatcctcaa attgagcgcc aatttgcttt tttaacactt ccttaggcgg 656821 ctttccggcg agatcttctt ctatattttt cattttgttc atagacatac cgatataata 656881 ttcacaggca gataacagca gcgcttcttt cgatttgaag tgcaaataaa aagcgccctt 656941 cgaaatgccg cattcactgg cgatttcttg gatcgtcgta gctgcgaatc cttttttcgc 657001 aaataaacga atgctggttt ttatgattct ctcttttttt tcattcatga cgtgcttccc 657061 cttaatcctt gaaaaattta gtaaaatttt ctggtatatg agttgacgtt gttgcgttat 657121 aacgtttagt attatataga atgaccagtc agtcaataaa aaatgtaatg gaggatatga 657181 tgaaccacgt tattaatttc gttctgaaaa acaaattcgc cgtatggctg atgacgatta 657241 ttgtaacggc agccggcttg tatgcgggta tgaatatgaa gcaagagtct attcctgacg 657301 tgaacatgcc ttacttgacg atcagcacga catatccggg tgcaacacca agccaagtgg 657361 ctgatgaagt gaccaaaccg gttgaacaag ccgtacagaa cttggacggt gtcagcgttg 657421 tgacgtcgac gtcctatgaa aacgcatcgt cggtcatgat tgaatatgat tatgagaaag 657481 atatggacaa agcgaaaaca gaagcagctg aagcgttaga aaacgtcaac ctgcctgatg 657541 acgcgaagga tccggagatt tcacgctaca gcttgaactc attcccgatt ctgacgctga 657601 gcgtgtccag tgataaagat aatctgcaag agctgacgaa acaagtggag gacagcctcg 657661 tttctaagct tgaaggcata gaaggcgttg cgtccgtcca agtatcaggc cagcaggtgg 657721 aagaggttga attctctttc aaagaagaca aactgaagga atacggcctt gatgaagata 657781 cagtcaagca agtgattcaa ggttcagatg tgacaactcc gcttggattg tacacattcg 657841 gaaatgaaga aaaatctgtc gtcgtcagcg gcgatattga aacaattaaa gatttgaaga 657901 atatgagaat cccgacggca tctgcttcaa gtgcaggcag cagcgcagca tctcaagcag 657961 gtgcgcagag tgctcaagca gcccaaagcg cgcaagcggc agcacaggtg cagcaaagcg 658021 caagcacagc agtgccgacg gtcaagcttt ctgacattgc tacaattaaa gatgtgaaaa 658081 aagctgaatc cgtttcacgc acaaatggca aagacagcat cggcatcaac atcgtcaaag 658141 caaacgatgc gaatacggta gaggttgccg acgatgtcaa agctgagctg aaaaagttca 658201 aagaagacca taaaggcttc aattacagcg caactctcga catggcggag ccgatcacac 658261 agtcagttga cacgatgtta agcaaagcca tcttcggtgc tatttttgcg attgtgatta 658321 ttctcttatt cttaagagat atcaaatcaa cattaatttc tgttgtttca attccattat 658381 cattgctgat cgcactcctt gtgctgcagc agcttgatat cacattgaat attatgacgc 658441 tcggcgcaat gaccgttgcc atcggacgtg tagtcgatga ctccatcgtt gtgatcgaga 658501 acatttaccg ccgcatgaga ctcaaagatg agccgctccg cggaaaagcc ttggttcgtg 658561 aagcgacgaa ggaaatgttt aaaccgatca tgtcatcaac gattgtgaca atcgcggtat 658621 tcctgccgct cgcacttgta ggcggacaaa tcggtgaatt gtttattcca tttgccttaa 658681 cgattgtttt tgcgcttgcc gcatccctag tgatttcaat cacgcttgtg ccgatgctcg 658741 cacacagcct gttcaaaaaa tcattaaccg gtgcgccgat taaagcgaaa gaacacaaac 658801 ctggcagact tgcaaacatc tataaaaaag tattgaactg ggcgctgagc cacaaatgga 658861 tcacgtctat catcgcggtt ctgatgctcc ttggaagctt gttcctcgta ccgttaatcg 658921 gtgccagcta cctgccgtcc gaggaagaaa aaacgatgca gctcacatac agcccagaac 658981 cgggtgaaac gaaaaaagaa gccgaaaatg aagctgaaaa agcggaaaaa atcctgcttg 659041 accgcaagca tgtcgatacg gttcagtatt cattaggctc tggcagcccg cttgccggag 659101 gagattctaa cggtgcgtta ttctatatca aatatgaaag cgacacacct gactttgata 659161 aagaaaaaga taacgttctg aaggaaatcc aaaagcaatc tgaccgcgga gaatggaagt 659221 cacaggactt cagctcttca ggcaataata acgaattaac atactatgtg tatggcgatt 659281 ctgaaaacga tattaaagac acggtcaaag acattgaaaa aatcatgaaa gatgaaaagg 659341 atctgaaaaa cgtaaattca ggcctttcca gcacatatga tgagtacaca tttgtcgctg 659401 accaagaaaa actaagcaag ctcggtttaa ccgcgtctca aatttctcag gccttaatgt 659461 cacaaacatc gcaagaaccg ctcaccactg tgaaaaaaga cggcaaagag cttgatgtga 659521 acattaagac agaaaaagac gagtataaga gtgtgaaaga tttagagaat aaaaagatca 659581 cttccgcgac tggccaggaa gtcaaaatcg gcgatgtggc aaaagtgaaa gaaggatcaa 659641 catcagatac cgtgtcaaaa cgtgacggaa aagtctatgc agatgtcaca ggtgaggtta 659701 cctctgacaa cgtcacagcc gtatcagctg ctatccagaa gaaaatcgat aagcttgacc 659761 accctgataa cgtatcgatt gacacaggcg gcgtatcagc ggatatcgct gattccttca 659821 cgaagctcgg tttagcgatg ctggcagcaa tagcgatcgt ttaccttgtg ctcgtgatta 659881 ccttcggcgg agcactagcg ccatttgcga ttctgttctc attgccgttc acagtcatcg 659941 gtgccctggt cggactttac gtatcaggtg aaacgatcag tctgaacgcc atgatcggta 660001 tgctcatgct gatcggtatc gttgtcacga atgccattgt cttaattgac cgcgtgattc 660061 ataaggaagc ggaaggcctg tctacgagag aagcgctcct ggaagccggc tctacacgac 660121 tccgtccgat cctgatgaca gccattgcga caatcggcgc cttgattcca ttagccctcg 660181 gcttcgaagg cggaagccag gtcatttcaa aaggactcgg cgtaacggtt atcggcggtt 660241 taatcagttc aacgcttctg acgctcctga tcgtgccaat cgtatatgaa gtattggcga 660301 agttccgcaa gaaaaaaccg ggaacggaag aagagtaaaa aacaaaaagc ctcagctctg 660361 ctgaggcttt cagcttgttg aaaaaccctc gcattcgttg tcaggtctgc gcgtcggtgc 660421 tcacgaattc tacattcgct ccgctccaat gctccccctt cctagactac aagggttttc 660481 aatcaagctg aaagaatgtt aaggatgaca aaagctcaaa acaagaatca gttttgagct 660541 tttgtgcgtt ttcacctgta agattatgta cattttgttg cgattttttt aactcatagt 660601 ataattaaag gttgttagtg taaaaatgga tcggatactc ttaagtagga tgatgagata 660661 atgaaacgtg cacgcataat atacaatccg acttcaggac gggagatctt taaaaagcat 660721 cttgcccagg tcctgcaaaa atttgaacaa gccggctatg aaacctccac ccatgcgacg 660781 acatgcgcag gagacgctac acacgctgcc aaggaagcgg cattgcgtga gtttgacctg 660841 atcattgcgg caggcggaga cggaacgatc aacgaggtcg tcaacgggct tgcgccttta 660901 gacaatcgtc cgacactcgg tgtgattcct gtcggcacaa cgaacgactt cgccagagcg 660961 ctcggaatcc cacgcgagga tattttaaaa gcggcagata cggtcattaa cggcgttgcc 661021 cgcccgattg atatcggaca ggtcaacggc cagtatttta tcaatatcgc cggcggaggc 661081 cgtctgacgg agctgacgta cgacgtgcca agcaaactga aaacaatgct cggccagctt 661141 gcttattatt taaaaggaat ggaaatgctg ccttcacttc gtccgacaga agtcgagatt 661201 gaatatgacg gcaagctgtt tcaaggtgaa atcatgctgt ttttggtcac gctgacaaac 661261 tccgtcggcg ggttcgaaaa gctcgcgccg gattccagcc tgaatgacgg catgtttgat 661321 ttgatgatac taaagaaagc aaaccttgct gaatttatca gggtcgccac gatggcgctt 661381 cgcggagaac acatcaacga ccagcacatt atttatacaa aagcgaaccg cgtgaaagtc 661441 aatgtatcag aaaagatgca gctgaacctg gacggcgagt acggcggcat gctgccgggc 661501 gaattcgtga atctgtaccg gcacattcac gtcgtcatgc cgaaggagaa agcggaacag 661561 ttggatgact aaaacttggc ttggtaagcc aagctcagaa tgttgacaaa atcctaaaac 661621 agttttcgtt ttaggatttt gtcatctttt cagcgtgatt gaaaaccttt gaagtctagg 661681 aagggcgagc atcggagcac agcgaatgtt gaattcgtga gcaccgaagc acaggcctga 661741 caacgaatgc gaaggtttgc ctacacgctg aaacttggct tgaataggcc aagtttttct 661801 ttcgcttaaa actagaggtg attatagatg aaaatgaaac ccccagtaga aaaaaatgaa 661861 tactacgatg tgacatttga ggatttgaca catgaaggag cgggcgtcgc aaaggtccaa 661921 ggcttcccga tctttgtgcc gaatgcccta cccgaggaaa aagcccaaat caaagtgaca 661981 cgcgtcaaaa aagggttcgc cttcggccgc ctgattgagc tgaaggaaga aagcccgcat 662041 agaacggacg ccccatgccc gatttacaaa caatgcggag gctgccagct tcagcacatg 662101 acctacgaag gccagctcct gtttaaacag aaacaagtca aagacgtctt agaacgcatc 662161 ggcaagctgg acctttcaaa agtcaccgtg cacccgacac tcggcatgga agacccgtgg 662221 aactacagaa acaaagcaca ggtgccggta ggagaacggg aaggcggact cgtcgcggga 662281 ttctatcagc aaagaagcca tgacatcatc gacatgagcg cctgcctgat ccagcaatcc 662341 aaaaacgacg aagccgttca agctgtcaaa gacatttgcg caaactacgg tgtcaaagcc 662401 tacaacgaag aacgccacaa aggctggctc cgccacatca tggtcagata cggcgttgtt 662461 acgggcgaaa tgatgatcgt cttcatcaca agaacaagcg acttcccgca caaagcgaag 662521 atcatcgaag acatcacagc gcaattcccg cacgtcaaat ccatcgtgca aaacatcaac 662581 ccaaacaaaa caaacgtcat ttttggcaac gaaacaaacg tcatctgggg cgaagaatac 662641 atctacgacc tcatcggaga cgtcaaattc gccatctccg ccagatcgtt ttatcaggtc 662701 aacccagagc aaacaaaagt gctctacgac aaagcgcttg agtacgctga gcttcaaggg 662761 gaagaaaccg tcatcgacgc ttactgcggc atcggaacga tttctctctt cctggcaaag 662821 caggcgaaaa aagtgtacgg tgtagagatt gtgccggaag caattgagga cgcgaagcga 662881 aacgccgaat taaacggcaa cacaaacgca gagtttgctg ttggagaagc ggaaaccgtg 662941 attccaaagt ggtacgaaga aggcattaca gctgatacgc tggtcgtcga cccgccaaga 663001 aaaggctgcg acgaagccct cctgcggaca attgtggaga tgaagccgaa gcgggtagtg 663061 tatgtgtcct gtaatcctgg cacgcttgcg agagatttgc gggtgcttga ggatggcggg 663121 tacgtgacgc gcgaagtgca gcctgtggat atgtttccgc atacgaatca tgtggagtgc 663181 tgtgtgttga taaaattaaa agaataaata gtcaaaaatc tatgctgatg gaactgttgg 663241 ttctctaaaa cgataattga tttcaatggt tccatttgca tgtacttcta tttcatctac 663301 taacaaatga agcatttcgg gggtaagtgt accttccttc atgaatttat ctaagctctt 663361 tttaaaatca attatttctt tttcaatctt ttgaaattct aggtccttag atagttggtg 663421 aagggtagtt tcaaaatttg aaatatcttc attggtgata tttatggcta attggtaatc 663481 ttctttagat ataacaccat tagcaagaga gataactaaa ttggatttat ctctcttttt 663541 atcgtttaat ttttcattaa tttcgattat cttagattcg attttttctt tgtactttaa 663601 cgctttttca cttaattctt taaaataatt ttccttactg aatttcaaat atatcttatt 663661 taggttggtt attactttat cagttaaatc tatttcactt acgtaatgat cactacatgc 663721 ttttaaacca tgtttattat aacttccaca aacataacct tttcgattct ttttaaaatg 663781 cattgacctc ctgcaatctt tgcaaaccgc agtatttgta aagagatgta cttcagcttg 663841 aggtctcctt ctttttctag ttattaaaat ctcttgtaca ataagaaagt cttctaaagg 663901 tatgattggt tcgtggcttt tttcaataat tatttggttt tctaggttaa ctgaccttct 663961 tcttttactg gtaacactcg gtctatattc tctacattgt tgtagtgtcc cagtatagtg 664021 aggattttcg agaatttttc ttattgaaga tccgtgccat ttgtcagtag cgttcttttt 664081 gcgggcaagc tgcgagggac tagtgacccc ttcgttatac aatccccttg ctattgcatc 664141 aaagcctttt ccagcaatat attctgaaaa gattctaata tttactattt tctctgcgtt 664201 tgctgaattt gagagagata tgattgtaga acgaactcaa gaaggtaaaa tgttggccaa 664261 gcagaatccg gatttccgag aaggaagacc caaaaagttc acaaagcagc aaatcaatca 664321 tgcattaaca ttactagaaa atcattcgta taaacaagtt gaagatatga ctgggatatc 664381 agtttctaca cttgtaagag ctaaaaagaa gaaagctgct gaagctataa atggataaat 664441 attgtgaatt aattattcaa tatcttgaga aatttttata aaagtaatca aaagtttaat 664501 gggggaaacg aaatggcgct cattgattta gaagataaaa ttgctgaaat agtgaatcga 664561 gaagatcatt cagatttctt gtatgaatta ctcggtgtat atgatgttcc acgagctaca 664621 attacgcgct tgaaaaaagg aaatcaaaac cttacaaaac gggttggtga agtacactta 664681 aagaataagg tgtggtttaa ggaggctaag aaaggaaagc tctttgacgc ccttattgat 664741 atagaacaac aagttgaata tctttcagct aagccacgat atttattagt tactgactat 664801 gatggagtat tagcgaaaga tacaaaaaca ttagaggctc ttgatgttaa atttgaagaa 664861 cttcctcagt atttcgattt cttccttgct tggaaaggta ttgagaaagt agagtttgaa 664921 aaggaaaacc ccgctgatat taaagcagcc gaacgttttg cacggatata tgatgtactt 664981 cgtaaagaaa acaatattat tgagactaat agagggttag atttatttct tattcgttta 665041 ctgttttgtt ttttcgcaga agatactgac atcttcaaac gaaatagttt tacgaattta 665101 attaagactt tgactgaaga agatggttca aatctaaata aattatttgc tgatttattt 665161 atcgtgttag ataaaaatga acgagacgat gttccatctt atttaaaaga gtttccgtat 665221 gtaaatggcc agttgtttac tgaaccacat acagagttgg aattttctgc caaatccaga 665281 aagttaatta ttgagtgcgg tgaattatta aactgggcta aaatcaatcc tgatatcttt 665341 ggttcaatga ttcaagctgt tgcttctgaa gaaagccgta gttatttagg tatgcactac 665401 acaagtgtcc ccaatataat gaaggttatt aaaccgcttt tcctagataa acttaatcag 665461 tcttttttag atgcatacga tgattataca aaacttgaaa atcttctaac acgaatcggc 665521 aaaattaaat tctttgatcc tgcatgtggt tcagggaact ttttgattat tacctacaaa 665581 gaattacggc gtatggaaat caatattata aaacgacttc aagaactctt gggagagtat 665641 ctttatgtac cttcagtaac tttatctcaa ttttacggaa tagagattga agattttgca 665701 catgacgttg caaaattatc actttggatt gctgaacatc aaatgaatga agaattaaaa 665761 aatgaagttc ataatgcagt acgcccaacg ttaccacttc atacagcagg ggatattcgt 665821 tgtgcaaatg ctattagggt tgagtggact gaggtttgtc ccgcacaagg atctgaagaa 665881 gtatatgttt ttggtaatcc accgtatctt ggttcaaaaa aacaaaacaa agaacataaa 665941 tctgatatgt tatcaatttt tggaaaagtc aagaatggta aaatgcttga ttatatttct 666001 gcttggtttt actttggtgc taaatacgct tcaactacaa atgcaaaagt tgcctttgta 666061 tcaacaaatt cagttactca aggggaacag gtttctatct tatggaatga gttattcaag 666121 tttggaattc aaatcaattt tgcctataaa tcttttaaat gggcgaataa tgctaaaaat 666181 aatgctgcgg taattgttgt gattgtaggt tttggcccgt tagataccaa agtaaacaag 666241 tatttatttg ttgatgaaac gaaaaagcta gtttctaaca ttagtcccta tttaactgat 666301 ggtgaaaata ttcttgtttc ttctaggacg aagccaattt cagacttacc caaactgcat 666361 tttgggaaca tgcctaatga tggcggagga ttactcttta ccattacgga atatacagac 666421 gcaatcaata agtatcctga attagttccc tattttaaaa agtttatagg ttcagtagag 666481 tttattaatg gtggtttacg gtattgttta tggcttaatg aagcaaaata tgaaaaaata 666541 aagtctaatc ctctaataca agaaagaatc tcaatttcaa aaaatcacag ggaaaaatca 666601 acagataaag gaacgaataa acttgcatta actccgtgga agtttagaga tactcatgaa 666661 acaactaatt attccattgt tgttccatct gtgtcttctg aaaatagatt ttatattcca 666721 atgggattag caggtgcaga tacaattttg tcaaatctaa tttatgtaat ttacgatgca 666781 gaaatttacc ttctaggcat tttgatgtca cggatgcata tgacttgggt aaaagctgta 666841 gccggaagat taaaaactga ctataggtac tctgcaggtt tatgttataa cactttccct 666901 attcctgaat tatcaacaag aaggaagaat gaaattgaag aagcaattct tgaaattctt 666961 gatcttcgtg aagagcaggg tggtacatta gcagagcttt ataacccttc aacaatgcca 667021 attgaattaa aagtagcaca tgaaaagttg gatggaattg tagaaagagc gtatcgtcaa 667081 aaacaatttg aatctgatga agaacgctta gaagtattgc ttaaattgta tcaagaaatg 667141 acagaacggt aggtgtaagg tgtatggaaa atataattga aattaattat aaccaaactg 667201 gtaaaagtaa gaaaacaaat gaatacggta tgcgtgaaat gcaggcaaga gcttttgaaa 667261 aacgtaactc acaatatctc ttagttaaag caccgccagc ttctgggaaa tctagagctt 667321 taatgtttat cggtttggat aagctcataa atcaaggttt gaggaaagtg attgttgctg 667381 tacctgaacg ctctataggt tcttcattta aaaatacgga tttaaaaagt tatggtttct 667441 ttgaaaattg gaaagttgat cctagaaata atttaactgt tggcggagat aactctaagg 667501 ttaaatcttt tgttcgtttt atggaatcgg acgatcaggt gttaatatgt acgcactcta 667561 ctttgcgatt tgcgtttgaa aaaattgatg ataaagcatt tgataattgt ttacttgcaa 667621 tagatgaatt tcaccatgta tcggcagatg tcaattctcg attaggtgaa ttgttaagaa 667681 gtattattca taattcatca gcacatattg tagcgatgac tgggtcgtat ttccgtggag 667741 attctgtacc aattttatta ccagaagatg aggaattatt tgacaaggta acttattcct 667801 attatgaaca acttgatgga tatgaatatc taaagggatt tggtatagga tatcacttct 667861 atcaaggcca gtacacatca gctattaatg aagtattgga tacaaataag aaaacaatcg 667921 ttcatattcc aaatgtaaac tcaggggaat cgacaaagga taagtacgat gaagttggta 667981 agatacttga tatgattggt gaagttgaat atcaagatga tgatactgga attatttatg 668041 ttaagcgaca ttctgacggt aaaacattga aaattgcaga tttagtagat gaccaagttg 668101 gaagagaaaa tgtcgttgcg tatttgcgta atattgaagc cctagacgat ttagatataa 668161 ttattgctct tggtatggcg aaagagggct ttgactggcc gttttgtgaa catactttga 668221 cagttggtta tcgtggctca cttacagaaa tagtacaaat aattgggcgc tgtacacgtg 668281 atagttacaa taaaacctat gctcaattta ccaacctaat cgcaatgcct gatgcaaagg 668341 atgaagtagt gacttataca gtgaatacaa tgcttaaagc tatttctgcc tcacttttga 668401 tggagcaggt ccttacacct gactttaaat ttaaacgtag aagaaatgaa agtgaaaaat 668461 cttctactac aggagaatta ttcgttaagg gattgaaaga accatcaaca gaaaatgtca 668521 aaaagattat tgaaaatgat attaatgatt taaaagcaaa aatcatgcaa gattcacaag 668581 tccaaaaaac atttagtgga gaagtagatc ccaaagtatt gaacaaagtg ttgattccga 668641 aagttattca aaaagtatat ccaaatttat cagatgagga aattgaggaa gttagacagc 668701 acgttgttct agatacagtt atgaaaggtg ctaagtctga agttgtagga agtaaagaat 668761 ttataagaat ggcagataag tttataaaca ttgaggattt agatatcaat ctgattgatt 668821 ccatcaatcc gttccaaaaa gcatttgagg ttctatcgaa agaattgaac tcaccagtgc 668881 taaaactgat tcaggaaact attgatgcaa aacgtattaa ttttgatgaa gatgaactag 668941 tattcatatg gccaaaggtt taggaatttt atcgttcaac tggtagaaga cctgattcaa 669001 aatctgaaga cccacttgaa aggcgtatgg gtgaagctgt attatacatg caagagctta 669061 ggaggaaacg tgaaaatggc aagtaataga taccattcta ttaatgaaat catggaaagt 669121 cagctgtttt accaaatcac aacaccacct aagaaaacac aaaaagccca gtatgatcct 669181 gaagttgaaa agtttttgga gattattgaa ttcgtcaaag aaaatgggcg agaaccccaa 669241 aaagtcccta ctgatttaac tgaaagaagt ttagcaagtc gattaattgg gattcggaaa 669301 gatcctgatc gtatggaata tttgaaagag tatgatgaaa ttggattact tgaagtaaga 669361 tcgaaggaac taacaattcc taaaatttct tcaattgatg atattctaaa aagtggctta 669421 tctgcattat taggtgataa tttaaataat gatataacta ggtcaatttt tgatacaagt 669481 tcacttcaaa aggttacgac aatgcctgaa tacgttgcaa agcgtaaaaa aataaaagat 669541 tttggaaagt ttgaagagct attcaagaag tgccacaagg aaattacaga gggtaaacga 669601 aaaattttaa ctttcaaaaa tgaacaagac atacagtcaa atagttttta tatattaaaa 669661 ggagttcttc tttatgttga agatgtggga gaacgtaaaa aagcaaaggg aaaaaccaat 669721 gctagacttc gatgtatatt tgaaaatgga acggaatcag atatgttact acgttcctta 669781 tcagcggagt tatataaaca tggtagacgt gtgaccgaca atgaagatac attgttggat 669841 aatgttagag aagatgatgt ttcgactggc tttatttacg tactaaaatc tttgagtaca 669901 gatccgcaaa ttagttccat taagaattta tataagatcg gttttacaac tggttcagta 669961 gaaaatagaa tcaggaatgc agaaaatcaa tcaacttatc tttatgctcc agtagaaatt 670021 gtaaccacat atcaagtgtt caatatgaat gctagcaaat ttgagacggc aatccatcat 670081 gcgctagcaa ataataattt ggatgtttct attttggggg caaatggaaa gatgttagtt 670141 cctaaagagt ggttcgttgt cacacttgaa gatttacaag ctgtaataga tgagattgtg 670201 atgatggttc atctttatga ctaaattagt atattaggat tttagtatta ataataattt 670261 tatagtagac tatgaaaaaa tttgatgcca taacaataac ttgttccgct ttggagtttg 670321 tcacaattgt agaattatgt gttgcgagta ttaataggaa ggggttgagc gaccgcaaaa 670381 aaaattttcg gtgctgtccg caaaagggag tttgggtgtt ttgcgttata tttggttgtg 670441 tgaaggttag cggaaactca attcgtgaag ttaggattgc ggttattacg actgagtagt 670501 ttcgtcatac tcttttagca gtttttctgt cttatgcatt tctttgagca tcggattcat 670561 gtagtcgtta gctgattcta gatatgctct cgtcagagtg tctagtttat ttctaacttt 670621 agagaggtct tcttcgaatt ttccatccga tgattgaagg ataaattctt ttgcctcttc 670681 atatcttttt aatatgtttt tcaccattgg agttggattc ttttgattta ttgtttttat 670741 tacagtgatt gttaaattta tttgttttat taattctttt cttactgtca aggtgatgct 670801 ccttttaaat ctctattcta tttgagagtt gctatatctg tttaatggtt tgatagacta 670861 ctcatcttta taatttagag caatttttac aacttgttcc gctgtgtaat cttcattgct 670921 ccagaaaatt aaatcacttg gtgccggata aggaacattt ttctctaata aatcgagata 670981 ttcactgact ttctcatcat ctaatgttgg gttcattaat tcctttacaa gaaagatcaa 671041 ctcttctttt gtcagtttat ccattgtttg ccctccaata gattgtatct ccattgattt 671101 tacaaatgac tttatttctt ctgataatgt tataggttgt ttgcataatg atagataatt 671161 gtcttgagaa aagttagtct cattatagag tttattaatt gtatttataa caatatattc 671221 atatggaaaa cctctaaaat atctttattt tagattggtt tataaaaaat agctcagcag 671281 agtagggctg agccattttt taattataga ccgaggtaac taattacaaa ttctttatca 671341 tcctcatctt caggcaaaat accaaggttt ttatattccc atattgcgat tctttcatat 671401 ccatctaatt ctgaggctaa aatatcatca taattataat ctaattggaa ttctccgcta 671461 cgatccaatg ttagtgtaag gttagtccaa acatcatcgt tattatttct gtgttcagtt 671521 cttaattctt caaaaagttc tcttagttct cttaacaacg tcttgaaaat atccttgctt 671581 acgttgtaat ggctaggtat atcttgtgaa taaataattt gattattttc tggtgttctg 671641 aaatgaaaaa gaaccattgt ggaatcatct aatacttctg cataaagata tatctttgtc 671701 cattcaccag gtatgatgtc attgagtttt tctccaataa gttgatacaa atcttgcatc 671761 ttcctagttt ccattcttct aacccccagg ctgattttta atagagacgc ttatttcttt 671821 tctgctccca attttgtagg ttacatcgaa atatgatggt ctaagtgaat ccccagaata 671881 gactggttct atttgaactg ctactttttt aggtggtttt ttgcttaggg cttttgccca 671941 ctcctgctcc atctcatacc atttcccacc gctcctatta atctgagaat tcatcggcac 672001 gatattgtca aactggcctg agcctttgaa ttgggtggcg attaaatggc cgccgtcatc 672061 gtcaggcttt cggtcctggg gctttccagc attcgtttgt gcatattggt ttcgtttcgc 672121 ttctcccagc tgcaagtctg ctttgacact tgtaattcta ccatagttgt cagtcgtgta 672181 cgtgtagcct tcttttgttt tgtagatgat attaggcttc agcactttct ttctgctcca 672241 tcttgcgaaa tgctcgccgt atttgacggt taccggcggt acatgtggcg ctggagttcg 672301 tcttccgctt gatgacgttc cgtatggttt cggcaggatg accttggcga atttttgcag 672361 tccttcttta agcgtgaccc cgttgactgc gttgtaagga acgcctgccg gcactaaatc 672421 atgacgggga tgatacggga gaatatccgc aagtgtgaga tctccgattt gatttaactt 672481 ggttttgacg tgtttttttg atacttcaat gcctgtgttt actttttgtt tgatgtgatc 672541 aacggtttgt tttgagactg ttatggcttt ttgggctgtt gctgatttgc ttgctgctgt 672601 tttgactttg gtcgtcactt tggcggctgt gccagttttt gagacggctc ctacgccttt 672661 tgtgccgaca attgatgtga caacagtgcc aaccgcatat gacacccatc ttgctcttga 672721 gtaggtgtca ccattcacca tgtctttttg atacgattct tcgattgccg ctgaaatggc 672781 ttcatacgtt ttgatcgggt gagccatcgc tccggtaatc gcttcaacgg ttcctcccgg 672841 atctgtgacc atatcccaca ggcctacgac cgcgtctttc ccggaatcat aaaggccgac 672901 ggcaacccct ttgaagcctg cttcaagctc acgcgtgttt tcaatttggg tgaagtatct 672961 ctgttgttca gctgtcagat tttcatagcc gatcgttttt gccatttcgt agaattcatc 673021 ggcatctgca taatcgtagt ttttcagtct ttctttcagt ttctcaatct cgcgttcctt 673081 cgcttcctct ttcttaatct tcaagtaagc ctcagtccgc ttttcaatgt cgcctttttt 673141 cttatgtatg tcactctcac ggtacgcctt ggcgttgtag tggatgggtg tggcgttttt 673201 gcctttaccc gttgcttctt ggagcttttg gaagtcggat ttgatgaatt gttcgtttgg 673261 ttcagacagg gcgtattctg ttttcaggtc ttcgtccaag gcgtccaatt tttccagtgt 673321 ttttttgcgt ttgtcgttgg catcggccag ctcgtctttg aaggtttctg ttgaaaacag 673381 gtcgagcggg aggatgtcgt cgatatcgtt taggatgtct ttcatcgctt ttttctgttc 673441 ggacatgatg gatttagatt ttttattggc atttgccagt tcgtgctcca ggaaggattc 673501 ttcgatgtat gcgtctgaga ggcctttgtc ttcggcggct ccggcgatgc tgttgaaaaa 673561 tgcgattttc atgtcgatgt agtcgatcca ctggtcggcg acgccgacgt ggtcgtgata 673621 gaatgccttg atgttgctgg cgccttttcc tgagaattca ctgtcactga gatcagcgac 673681 tccttttaac gcttttctca agttgaccat ttgcgttctt agttctttgt actcttttgc 673741 acggtctgtc gcttccgaaa gcagtgtttt cgcttcaaat actttcatga ccatttccct 673801 tcttttgttc gctcaatatc aaaattttac cacgggtcgg gataaggtgg gggtgagaac 673861 gtgttttggt ggaaaaatga gtcatttggc atgtgtcttt attcgtggag ggattggagg 673921 aaacatggtc gaaatgatat tgattgctac acattttttg gaagtttgta ttctatattg 673981 ttttttaagg agcatgttga tgacgaaaaa acggattaca tttggtttat tagttttaat 674041 ggtatgtgtc atcctgtttg ttctgtatgt tcagttacgc aataaagata gtattcctgt 674101 ccaatcttcc gccattcacc ccgaagaaga ccgcatcttt tttatttact ccaatccttt 674161 cataaaagaa agcgtgctgc tttcaacctc tacaggcgaa cggtttaaca ggcgtacgtt 674221 taaggtggcg gatgtgcctt atattcaaac gaaatcttat gcatcaacag accttgtatt 674281 attggcggaa cacgagcctt tttactacac gctggagaag gatgtgatca aagagcatcc 674341 gctgtcagat ccatttgcgt tttggtatga ggggaaggat gtcactattg aggcctataa 674401 tgttgatacg acgggaaatg agatccacat aaacgacaga aaaacgaaaa aggaatatac 674461 ccttaccttg cctccgcttg tcacaatggg ggccagtgat gagaacttta tttatatcat 674521 tcaaagcatg tctatttacg tgattgacag aaaaacagag gaaatgattg agaccctgag 674581 cttagcctca tacgctgatc aattcgcaga ctcggaggaa tttatcgtcg cgagctcgga 674641 tcataaattg actgtgattg aaaaagggac atggaagacg acatatattg cgtatcctga 674701 agatcttgaa tatgcagata ctgtgtacta tgacaaagaa agcggcagtt tttacgtggc 674761 gtacgaggac aaagagggtg gagcgaactt gctggaatat ggggaggatt tttctattca 674821 cacatacagc ttgaaattcc cttatatgga ggcgaagttt aaggggaatc tattgtatat 674881 agttgcccag gaagagcata aaaagggcat cggcggatac gtgggtgtgt ttgatatcca 674941 ttctaaggag atgctttatc agtttgattt gcctgaggaa caggtgaagg ttcaggattt 675001 tgttgtggtt gacaataagt gaatactata tgaaatagaa tgacaaagac ccttgcataa 675061 agggttcttt tttatgaaaa aaacaaattg acaggatgaa aaaacaattt cttccttcta 675121 tattgttttc aaaatttggg attgatagaa tatgacatat ctcatagaga aggagggaag 675181 ccgttgagtc aagccatacc gtcttcgcgt gttggtgtta agattaatga atggtataaa 675241 atgattcgcc agttcagtgt tccggatgct gagattctga aagcggaggt tgagcaggac 675301 attcagcaga tggaagaaga tcaggattta ctgatctatt attctctgat gtgttttcgg 675361 caccagctga tgcttgatta tttggagccg ggaaaaacat acgggaatcg ccctacagtg 675421 acagagcttc ttgaaacgat cgagacccct cagaaaaaac tcacaggtct tttgaaatac 675481 tactctttgt ttttccgcgg catgtatgaa tttgaccaaa aagaatatgt ggaagcgatc 675541 ggatattatc gcgaggcgga gaaagaactg ccgtttgtgt cagatgatat tgagaaagcg 675601 gaattccatt ttaaagtggc agaagcgtat tatcacatga agcaaaccca tgtgtcgatg 675661 tatcatattc ttcaagcctt ggacatttat caaaaccatc ctctatacag cattagaacg 675721 atacaaagct tgtttgtgat cgccggcaac tatgatgatt tcaaacatta tgataaagcg 675781 ctcccgcatt tagaggcggc gctggaattg gcaatggaca ttcaaaatga caggtttatc 675841 gccatttctc tattgaacat tgcaaacagc tatgacagat caggagacga tcagatggct 675901 gtagaacatt tccaaaaagc ggcgaaagta agcagagaga aagtgcctga tctgcttccg 675961 aaagtcttgt ttggattaag ctggacatta tgtaaagcgg gccaaacaca gaaggcgttt 676021 cagttcatag aggaaggatt agaccatatc acagcacgtt ctcacaaatt ttataaagaa 676081 ttgtttctgt tcttgcaggc cgtgtacaag gagactgttg atgaacgaaa aattcatgat 676141 cttttaagct atttcgaaaa aaagaacctg cacgcttaca ttgaagcatg tgcccggagt 676201 gctgccgctg tttttgaaag cagctgtcac tttgaacaag cagctgcgtt ttatcggaaa 676261 gtgctgaaag cccaagaaga tattctaaaa ggagagtgtt tatatgccta ttaagaaaaa 676321 agtgatgatg tgtctggctg ttactctagt tttcggaagc atgtcgtttc caaccctgac 676381 aaactccggt ggatttaagg aatcgacaga tcgaaatacg acgtatatcg atcattcccc 676441 ttacaaactt agtgatcaga agaaagccct tagctagggc tttttcttgc tttacggaag 676501 acgttccatt ttccacatcg cggcattcct tctatttcta acgcaagaca ctcgaaacaa 676561 ccaaaccatt tgaggtataa tggataaagt gaataacagt atttagattg atatatatga 676621 aagagagtgg aacatcatgg gccgtaagtg gaacaatatt aaagagaaga aggcgtctaa 676681 ggacgcaaat acgagtcgga tttatgcgaa gtttggccgt gagatttatg tggcggcgaa 676741 acagggcgag cctgatccgg aatccaacca ggcgctgaag gttgtgcttg aacgtgcgaa 676801 gacttacagc gtgccgaaaa acatcattga acgtgcgatc gagaaggcga agggcggagc 676861 ggaagagaat tacgatgagc ttcgttatga gggcttcggg ccgaacggat caatgattat 676921 cgttgatgcg ctgacgaata atgtaaaccg tacggcgccg gaagtgcgtg cggcgttcgg 676981 gaaaaacggc ggaaacatgg gtgtgagcgg atctgttgct tacatgtttg acgcgacggc 677041 tgtaatcggt gtggaaggca aaacggctga cgaagcgctt gaaatcctga tggaagcgga 677101 tgttgatgta cgtgacattt tagaagagga tgacagcgcg atcgtgtatg ccgagcctga 677161 tcaattccat gcggtgcaag aggcgtttaa aaacgcgggt gtcgaggaat ttacagtagc 677221 ggagctgaca atgcttgcgc aaagtgaagt aacgcttccg gatgatgcaa aggaacagtt 677281 tgaaaaattg attgatgcat tagaagattt ggaagatgtt cagcaggtat atcataacgt 677341 tgatttaggt gagtaaggag tgagcaggct gttatggcct gctttttttg tcccggaaat 677401 tgttttagct gtatgtaggc ggccgcctat acgatctata agatattctc atactctgga 677461 ctgtaaccta tgtgaaggag agagtaaata tgactgatac aagacatatg tatggcggac 677521 ctggttttgg tcattatcag ggctttggta ttggccaccc gggctatggc atgcaaagca 677581 caggctatcc gggctatggc atgtatggag gccacccggg ctatggcatg caaggctacc 677641 cagatcacgg catacatgga ggagtcggcg gctatccggg atatggtggg tacggcggtt 677701 acccaagcgg cggctatgga ggctctccgg gaactggaag ctatccgagc atgcaccatg 677761 aaaatgatgg ccatcaccac tattatcacc atcatcatga tggaaaagat aatcttcatc 677821 accatcatca ccatgttgga aaggataatc atcaccacca tcatgatggt cattatggcc 677881 accatcatca ccatatgggc cactggggaa aagacggtta taaataaaga agatgatgat 677941 aaaaagagga cactcttgca gatcaagagt gtttttttag cttttttctt gactgttcag 678001 tctggaaaat ggtaacattt gtttcaggag gtgatcattt tttggggagg aataaagaat 678061 ttgatacggc gcttgttctt cacagggcga tagaggtttt tggagagtat ggctacgaag 678121 gaacgtctct tcaggatctg ctctctcatt taggcattgc gcgccaaagt ttgtatgata 678181 cgtatggaac gaagcgtgat ttgtttttgt ccgctgtgaa atcgtatctt gaagggaaaa 678241 acgctgccgt tatggaaagg cttgaagcgc caggatctgt aaaggaagcc attcgtgata 678301 tttttcagga gggtgtcaat gccctgaggg atccggaacg ggcgaaggcg tgctacatta 678361 ttaacagcgc gattgaacag atcccgcatg accctgagct tgcccggtat tttgaaagac 678421 aatccaagca gcttgaggac gctttttatc acgggctttt aagagcgaag gatcaaggag 678481 aattgaatgg cgaagatact gatatatctg cgcttgctcg gtacctgaat cagagcaggc 678541 tgtcactgac atttattgca aaagtgacgg cagatatgga tcggcttcag gaccatgttg 678601 acgtgagttt atcagtgctt gattaacatg tggtaaagga ttctttgccc atgtatgtac 678661 tttttggact gaatagtcta gaaataaaaa tgaggtgatg atgaatgttg atgaatgagt 678721 ttgaaaaagc atgtgaaaca ttgagaaagt ttatggctta tatgcttgag aaggacatga 678781 agagctggac ggagctttgg gatgagaatg ctgtatttga gtttccttat gcgccggagg 678841 gatcaccaaa aagaatagaa ggaaaagcgg ccatttacga ttatattaaa gattatccta 678901 agcagattca tctttcttca tttaccgctc cgacagtgta ccgttcagca gactcgaata 678961 cggtgattgc ggagtttcaa tgtgacggcc atgtgattga gactggactg ccttatcgcc 679021 aaagctatat cagtgtcatc gaaacgagag acggccgcat tgtgcgttat agggattatt 679081 ggaatccgct tgttgtaaaa gaggcctttg gaggatcatt tttgcaaaca gaggagagtg 679141 ggaaatgatg aaacagaatc cgattttaat cacgggcggg accggcacag tcggcagccg 679201 aatcgccagc cgtttaataa agctgggata cagagtgcgt attgcaagcc ggaaaaaggg 679261 cgcgcttgct gatgctgagt atgtgtattt taattggaag tacgcctcca gttttacgcc 679321 tgctctggaa caggtaaaac agatctatct tgttgctccg gtcggtgtat ttgatccggc 679381 tccctatgtg cttccctttt taaaggaagc aaagcgtctc ggcgcaaagc gggtagtgat 679441 gcaaagtgcg tctgttgtct ccgagaacgg tcccgtgttt ggcgcgcttc accaggcagt 679501 gcgcgagttt ccagaatgga cggtgctgcg gccctcatac tttatgcaaa atttcatcaa 679561 tgtccagcac cgcatgtcta ttcaaacgga ggggcgcatc acaacggctt cgggtgaagg 679621 aaaacttggg tttattgacg ctgatgacat cgcagaaaca gccgtcaggg ctttgattga 679681 tgatgttcct catcaaacac atcatattct gacaggtccc gaggcgctga gctatgccga 679741 agcggcggag atcattggag ctgcggcggg acgccgggtg gagcatgtca gcatttctcg 679801 ttccgagctg cagcataaaa tggaggcagg aggtttgccc gcggattatg cccattttat 679861 ggcgaagctt gatgaggcaa ttagccatgg tgcggaacat cgggtaacgg atacagtgaa 679921 gcgtgtgacg ggaaaagaac ctcgttcgct gtcagagttt gcggctgctc atgctgcata 679981 ttggacctca ttttggactg aatagtctag aaagaccttc ggcgcttccg aaggtcttct 680041 tattgaaaaa gctaagtcgt gttttagtca taatcatgcc tcctgcctca tacctattaa 680101 ggtcattgtt tttgagaaag gaggagccgg aatgaaggat atgcagccgt ttacgcctgt 680161 caaatcatat acgccctttc acagccgttt tgatccctgt ccgcccatag ggaagaaata 680221 ttacagaacg ccccctaacc tttatatgac ctttcagcct gagcacatgg agcagttttc 680281 gccgatggag gctttgagga aaggcaccct ttggaaggat ctctatgatt tttatgaaaa 680341 cccttatcga gggggagacg cacatggcaa aaaaggttga cgccgaatat tatcgtcagc 680401 tagagcaaat acaggctgct gattttgtgc ttgttgagct gagtctttat ttaaatacac 680461 atcctcatga tgaagatgcg ttgaagcaat tcaatcaata ttccggctat tcaaggcact 680521 taaaaagaca gttcgaatcc tcttacggac cgcttctgca gttcggcaac agccccgcgg 680581 gcaaggattg ggattgggga aaagggccat ggccgtggca agtataagga ggaatgcctg 680641 aatgtgggtg tatgaaaaga agctgcaata ccctgtcaag gtcagtacgt gcaacccgac 680701 gctggcgaag tatttgattg agcagtatgg cggagcggac ggcgagctgg ccgcggctct 680761 ccggtatttg aaccagcgtt atacgattcc tgataaggtc atcggccttt taacagatat 680821 cggcacggag gagtttgccc atttggaaat gattgcgacc atggtctata agttaacgaa 680881 agacgccaca ccggagcagc tgcgtgaagc tgggcttggc gatcattacg tcaatcacga 680941 cagcgcgctt ttttatcata atgcggcggg cgtgccgttt accgcgagct atatccaagc 681001 gaagggcgat ccgattgccg atttatacga agatattgcc gcagaagaaa aggcgcgggc 681061 gacgtatcaa tggctgattg atatttcgga tgatcctgat ttaaacgatt ccctgcgttt 681121 tttgcgtgag cgtgaaatcg tacactctat gcgcttcaga gaagcggttg aaattttaaa 681181 agaagaacgg gataaaaaga agattttcta ataggcagat tggcctctct ttcatacacc 681241 cttttacata cagagaaaat ggtctgtttt tgcagtttgg tctgcattat aatcaaggtg 681301 tgtgtgcaag cttacttttt gattgggagg cctttatgac agcttttaag attgagaacg 681361 aaacgattgc agatggattt tacgcgtgtc cggccgtcta tgaggatgca gaatcgatta 681421 ccgggttgct cgtccgaaca gctgaatggc tccgggatcg gggttctaac caatggagcg 681481 gacttctcaa agggcaagat atacatgata tcacggggtc aattgaaaag ggacatgtgt 681541 ttgtgtttaa aaaagatgaa gagcttgcgg ctgtcgtgat gctgctgcct gcaccgagcg 681601 agtgggaccg gacgctttgg ggagacgatg ggcatgagga gtccatttat ttacaccgcc 681661 tcgcagtaag ccgccggttt gcgggacagg ggcttggagc ccgcgtcctt cagtgggcgg 681721 agacgggcat acactttccg gaaaaaacgc ggatccggct tgactgtgtc gctgatagtg 681781 acgccctgca ttccttttat cggcgtatgg gatatgaatt catgggtgct gatgcgtccg 681841 gatatcattt gtttgagaaa gagattacgg cagaataagc gtcctttgca gggggctttt 681901 ttgtcttttt ctaaaaggga ggcaggcgat gtgtggtcaa tattatttgt gacagggatt 681961 gtgacggctt gtctgtttgc tggcgtatcc gtattgatgc ggatgagatt tcctgacaaa 682021 agtcggccgg aatggatgtt ggccgggctg atcgtccttg gtgtgtttgc gatctggtac 682081 agcctcgtgt atgtacgcgg ctgggaaggg gctgcgctcg gaatgcttgg attcaatgtc 682141 attttcggag ccattgccgg atatttgatc gataaggcca tccggcgtta caggaaaaga 682201 taaggctgct gccgtctctc aacaggtcga aattttcaca gaccggcagg aattttcttt 682261 cgaaaggaga aatacatatt actttaaaat gaaagcgttt tccaaagcag gaaggtgatg 682321 ttgatgatac acagtgtggc aaatgggctg aatcattttt gtacgtgggt gatgagactg 682381 gcctatttga atgtgctttg gattttgttt tctcttgcag gcctggttgt atttgggctg 682441 atgcccgcta ctgccgcgat gtttacagtg gcgagagaat gggcgaaggg gaatacagat 682501 gccccggtgt tttctgtctt ttttcggacg tttaaaaagg aatggcgggc atcacagatc 682561 ctcgggctta tcgttgtgac ggctgccctg tttctgtttg cggatatgcg gatagcggct 682621 cagatggacc agcctgtgct cgtcaatgta ttcgtgagca ttagtttgat tttcgcgttt 682681 gttgtgctgt atgtgttccc ggtattttct cattttgacg taaaaatcag agaggtgctg 682741 agcatcagct ttttcattgc cttcagtcgt ccggcggtga cgcttttgat ggcagcgggc 682801 gctgtcggtg tgctttgtct cgttctgttt catgtcacgt ttctattgtt tttcagcggg 682861 agtttactca gcctgatctt aacgaagctg tcctttaaag cgtttcggtc aatggatcag 682921 cggcaggaga aagaaaaggc ggcatgaaga aaagagttgc tggctggtac aggcggatga 682981 agattaagga taagctgttt gtgtttctat cgttgattat ggccgtatcc tttctgtttg 683041 tatacagcgg ggtccagtat gcctttcatg tgtatgatga gcagatttac cgcaagtcct 683101 cggaggtgct tcggatgtct tctgaaagga tcgaagacga gctgaagaag atagaggatg 683161 tgtcatatga aatcattaca gacgaacaga ttcagcgcat cctgagcatg caaaatcggg 683221 atgatacgta tgatcaatat caaatgaagc aggagctgtg ggatcagctt gcgggatatg 683281 ccagcgatga aaagtacatc gattccattc atgtgattga tgcccgcggc tcagagtatt 683341 cagccggaag cagttcttca gatcttttgc agcaggagca ggaagaggta tttaagcgag 683401 cgaaagcgaa aagtggaaga aatctttgga tgacgctcgg cgggtcagac cccgtcctga 683461 tttcagcacg gcagatcagg tcctatcacc agctgagtct gaacggcttg ggcatggtac 683521 tgatccaggt caatgtaaaa cagatgattc gtgatgtgcc gaaggattgg ggcgattcag 683581 tcggagacat tatgattgct gaccaaggcg gtaatttggt gtatacggca catgcatcag 683641 cgcatgttcc tgaggcagca aaagagacgt tgaagcaccc cggttatgac ttgataaaaa 683701 agaatggcaa acgttacttt atttcttatc ttcaatcatc ctaccaaaat tggagctact 683761 ataacgttat cccctttgat cagatgttcg caaaaatttc ctttatgaaa acagtgatcg 683821 gcacatgctt tcttctcttt ttctgtgtgg ttttgctttt cggaaggaaa atcgccaaca 683881 gcatcacgga gccgattgaa cagcttgtga ccgcgatgaa atcggtacag cacagcggca 683941 ttgaagcagg tgtgtcgctt tctctgccgg aacatacaca ggatgaggcc ggcatgctga 684001 accgccattt tactgtcatg atgaaacgga ttaatgagct gatggaagaa aatgtggaaa 684061 aacagctcat cattaaagaa accgaattga aagcactgca agcccagatc aatccgcatt 684121 ttttatataa cacgctcgag tccatcaatt ggctggccaa ggcgaatcag caaaagcaaa 684181 tctcaaaaat ggtggaatcg ctcggttttc ttctgcgaaa cagcatacat atgaagaagg 684241 atatcgtgac cattcaggag gaggcggaca ttgtacgtca ctatatgacc attcagcgat 684301 ttcgatttga agagcgcctg aaattcacgt tggatattga cgatgaggtg aagcattgcc 684361 tcattccgaa actgacgctc cagccgcttg cggaaaatgc gattcaatac gcgcttgaac 684421 cctttacaag gccatgcgcc atccggattc aggcgaaaaa ggcgaagggc tgtgtctgta 684481 ttacggtcga agataacggc cctggcatgg atggacggat tcttgaatca acgggtggaa 684541 gaggaatcgg actttggaat attcgcgagc gcatcagcct gacattcgga gagccatacg 684601 gattgcggat tcatagtgag catgaaaagg ggacgaggat tgtgatcaca ataccgtgcc 684661 gaaatgaggt ggtgtgatgt ataaaatact gctggctgat gatgagagga ttatccttga 684721 tggaatggcg ggaatcattg agtgggagtc gcttggcgcc tcattgatcg gaaaagcgca 684781 gaacggacat gaagcatatg aaaagattgt acataagcag ccgcatatcg tcatcacaga 684841 cgtcaaaatg cccggcatgg acgggcttga gctgatcaaa aaggtgtcag ccgtcagccc 684901 gtcggtgcaa tttatcgtcc tgtccgggtt tggagagttt gagtacgcaa aggaagccat 684961 gaaatatggg gtgaagcatt atttgctgaa accctgcaat gaacagcaga ttatcagctc 685021 gctggaggaa atcattgctg agctgaagcg gcaagatgtg cacaaaaaga aaacagccca 685081 tctgaaacac gagctggacc atatccgttc ctttgcagcc gatcaatact tggaaggctt 685141 gatcgccggt gtggcccagc tttctccgcc gccttcactt gccggaaaaa agatccgcct 685201 cttgatctta aaaggggaac aatctattga tgctgcagcc agagaggcac tcggatcggc 685261 actgacagcg gtttgcagca gcggtgaatg gaccgtgctc gccgtagagg agaacgccgc 685321 tgaaaaggtg gcggaggttt ttgcggaccg caagatggcc atcagtcagg cgggagaact 685381 ccggcacgcg gggcagctgt ttcgtgacac agctgaagcg tctggtgacc tgcatgggag 685441 cgcagtgatt tcaaaaatga tcaggcttat tgccgacgag ctcggaaatc cgaatctgtc 685501 cttaaaatgg gcggcgaagg atatgctgtt tatgaatcct gattatctcg ggaagttatt 685561 taagcaggaa acaggcgaga aattttccca atatgttaca cgggtgcgtc ttgagcatgc 685621 gatgaagcag atgaaaataa ggagggacgt gagcgtttca gaaattgctg aagaaatcgg 685681 gtttggcgat aatccgaagt atttcagtct tgtttttaaa aaatataccg gtctgacacc 685741 gtcagaattc agaagaaaac agggaggcgc ttccgcagga tagccatctc tgtttttttg 685801 actttcgcca ctgttttttg agtgtttcgc cctatccgaa cgctttaaaa taaaatgtaa 685861 gcacttacat taaagggggg attggtttga agaagatttg ttacgtgctg ttatcccttg 685921 tctgcgtctt tttgttcagc ggatgttcag cgggtgaaga ggcctcggga aaaaaagaag 685981 atgttacact cagaatcgcg tggtggggcg ggcagccaag gcatgattat acaactaagg 686041 taattgaact atacgagaaa aagaatccgc acgtccatat tgaagcggaa tttgcgaact 686101 gggatgacta ctggaaaaag cttgcgccca tgtctgccgc cggccagctt cctgatgtca 686161 ttcaaatgga taccgcttac ttagcccaat acggaaagaa gaaccagctg gaagatttaa 686221 cgccgtatac aaaggatgga acgattgacg tcagttcaat cgacgagaat atgctgtcgg 686281 gcggaaaaat cgacaataag ctttatggat ttacgctagg tgtcaacgtg ctgtctgtga 686341 ttgccaatga agatttgctg aaaaaagccg gtgtgtctat caatcaggaa aactggacgt 686401 gggaggatta cgagaagctg gcgtatgatc ttcaggaaaa agccggtgtc tacggttcca 686461 acggaatgca tccgcctgat attttcttcc cttattattt gcgcacaaag ggtgagcgct 686521 tttataaaga agacggcact ggcctcgcgt atcaagatga tcagctgttt gtcgattact 686581 ttgaacggca gctgaggcta gtgaaagcga aaacgtcccc aacacctgat gaaagcgcac 686641 agattaaagg gatggaagac gattttatcg tcaaaggcaa atcagcgatt acatggaact 686701 actccaatca atatttgggc tttgcccggc tgacagactc gccgctgtct ctctatctgc 686761 cgccggagca aatgcaggaa aaggcgctga cactgaagcc cagtatgctg ttttccattc 686821 cgaaaagctc tgagcataaa aaagaggcag cgaaatttat taatttcttc gtgaataatg 686881 aggaagcgaa ccagctgatt aaaggcgagc gaggcgttcc agtctccgac aaggtggcgg 686941 atgcgattaa accgaagctg aatgaggaag aaaccaacat cgtggagtat gtagaaaccg 687001 cgtcaaaaaa catcagcaaa gccgatccgc cagagcctgt gggaagcgcg gaggtcatca 687061 agctgctgaa agatacgtca gatcagattc tgtatcagaa ggtatcgccg gaaaaagccg 687121 ccaaaacgtt ccggaaaaag gccaatgaga tattagagag gaataattga cgggaaatgg 687181 ggctgacgca atgaaaaaaa gccggagtat aagaaaagac aatctggcgg gatatgcttt 687241 tatttctccg tttatcatcg ggttcctatg ctttacggtg attccgatgg gggcgtccct 687301 gtttctgtcc ttcacgagct atgacttgtt tacggcgccg aaatggatcg ggctcgacaa 687361 ctttaaggaa atgtttacgg gtgacgaaaa gtattggcag tctctgaagg tgacgtttac 687421 gtatgtgctt gccggggttc cgctccgcct cggcttcgcg ctttttatcg ctgtcatttt 687481 aaacaatgca gcaaaaggaa cggccattta cagaacgctc ttttatctgc cttcgatcat 687541 cggcgggagc gtcgccgtgg cgattatgtg gcgcaatatt tttggcaatg acggggtcat 687601 caatgcgctg ctgttttttg tcgggattga tcaaaaaatt ctttggtacc agaatccgac 687661 aagtgcgctg tggacattga ttctgctgtc cgtctggcag ttcgggtcgt caatgctgat 687721 ttttttggcc gggctgaaaa acattccgtc ttcgtatttg gaagcggcaa gtgtggatgg 687781 ggcaaatcgg gtgcagcgtt tcttcaagat cacgcttccg atccttacac cgattatttt 687841 ctttaaccta gtgatgcaga cgatttctgc ttttatgaca tttacacctg cctatatcat 687901 ttcgaagggc gagggcgggc cgcttgacgg gacacttctc tattcgctct atttgttcca 687961 gcgtgcgttt aactattttc aaatgggcta cgcatcggcg atggcgtggg tcatgcttgt 688021 cattgtcggg ctgattacgc tcatattgtt taaaacatcg tcatattggg ttcattacga 688081 gtcaaaggag gaatgacgga tggagccggt caaccagcct gtcagagaag ccccggtttt 688141 tgagagaaaa aaagccgggc gcgtcagtcc caaacgcata ctgttccatg tttttacggc 688201 aacgctggcg gtgttgctgc tgtacccggt tatttggctg tttgtcagct cgtttaaaga 688261 aagcgccagt atttttacaa cctcacattc tctcattcca gaccctttta ttctcagtaa 688321 ctatgctgaa gggtggaagg gcattgcggg acagccgttt ctgacgttta ttaaaaactc 688381 ggcgattatt gtcgggctgt caacaatcgg tgccgtcatg tcatcggctg tcattgcgta 688441 cggatttgcg cgtataccgt ttaagggaaa aaaattttgg tttgcgtgca tgatggggac 688501 gttaatgctg cctcatgaag tgttgatgat tccgcagtat attatgtttg cgaaattaga 688561 ctggctgaat tcctttaaac caattgtcgt tccgcaattt ttcgggcatg cgttttttat 688621 ctttctgatg atccagttta tccggacgat tcccgaggag ctggatgaag ccgcgcgaat 688681 cgacggatgc ggacgctttg cctgcttttg gcggatcatt ctcccgctga ttgcccccgc 688741 gcttgcgacg tctgcgattt tctccttcta ttggaagtgg gaggagctga ttcagccgct 688801 cttgtatttg aataagccgg agctttaccc tgtttcactt gcgctgaagc tttttctcga 688861 tacagagtcg gcttcgaact ggggcgcgat gtttgccatg tcagccgtct cgttattgcc 688921 tgtgattctt gttttctttt tgtttcagaa atatatcgtt cagggcatca gtacgaccgg 688981 attaaaataa aaaggagtgt tgcagatggc acagcttatc tttgatgaag aaaaggtgac 689041 gtcggttatt gaccggatcg tgaaacggac atttcagatg gattttgcgt gggattggcc 689101 gggcggcgtt gcgttttacg gtgtggcgga ggcctatgaa gcgacggaaa acgaggaata 689161 tatcaatctg ttaaaaacgt gggtggatga acagctggag gatgggctgc cgccgctttc 689221 gatcaacgga gtttccattg ggcatacgct tttgttcctc cacaaggtga caggtgatga 689281 cgtgtatttg gaaacagcgg ccgagatggc ggaatatgtg ctgcataagg cgccgcgctt 689341 tggcgagggt atccttcagc atacggtgaa tgcggcagaa tacgtattcc ctgaacaggc 689401 atgggcggat acgctgatga tggctgggct gtttatgctg agaatcgggc gggtcatgga 689461 gcgtgaggat tattttgaag acggcctgcg ccagtttcac ggacatgagg atgtgcttca 689521 ggaccctgtc acgaatttgt actaccacgc ctgggacaac aaagcgcaaa atcatctgtc 689581 ggggatttat tggggcaggg cgaacggctg ggcggcactc acgatggcaa aggcgctccc 689641 gcttattgag gtgacacatc cttcctttat gatcatcgac ggatcgctca gagaccagct 689701 gagcgcgctt gtccggcttc aggatgaatc agggctgtgg catacaattt tggatgatcc 689761 ggattcttat ctggaggttt cggcatcagc gggtattgct tctgctctga tgtcgagcgg 689821 aaagctgtat acaaaatatg tgcagaaatc gcttgccgcc attttggatg cagtggaaga 689881 ggacggacgg gtcagcaggg tatcggccgg gacagccgtc atgaaaaatg ccgaaggata 689941 caaacaggtg ccttacaaac gaatacaagg atgggggcag ggacttgcgc tgacgtttct 690001 tgctgatgtt ttgaaaacga aaaaacgctt gtatcagtaa agatagcggc ggggggagag 690061 ggatgaaaaa acagcctcaa cagaaggaac gggtttctcg ctggaaggga acgtatttca 690121 aaagaaactt tgtcttcatt ttgctgattg cctgtattcc cggattgctg actggcggcg 690181 caatctactt tctttcgatc gacaaggtgg agaaagagct gcagagatcg catgaaacac 690241 aggtggcgcg tgaggtcagc cgaatggatg agaagctggg agtgcttgaa ctggcactca 690301 cccagatggc ctacgattct tcactgatga acggattggc cgagagggat ttggagaaag 690361 actttacgtt ctcctatcaa ttaacgaaaa agctgtttct tttgcgggat cagcagccgc 690421 tgatcgagca ggcttccatc tttctgaaca gcccccggcc acttgtgctg agccctgaat 690481 acagcgcttt gacagaacag gaggcgcttc gcaagtatcg ctcgctgctt gcctcagacc 690541 acagcattta ttggaaacgg tcgggaaacc aagcgatgct gatccagctc attccgggcg 690601 cggcggagaa accgttcggc gcgatcatgc tggcggttga tccgaaagaa atggaatcaa 690661 tcctgcaaag cttgtccccc tatcctgatg gcagtgcgtt gcttttagat caaaatcgag 690721 aggtgctgtt tcatgagggg gaaaaagatt ttgaaaagac tttacttcat gagataaaaa 690781 aacagcctgc tgagaacggc cattttcaga tggaatggaa aggcaaggtg tattctgtct 690841 cctttggaga aatgaaccgg atgcatcagc aatggacctt tgtgtcagcg gcgcctcttt 690901 cagctattac agcgccgatg gtgtttttat caaaagtgat catcgtgatg ctggtcattt 690961 gcatcggttt ggcggtgtgc atgacatggt atgcatcaaa aaaaatctat cgtcccatcc 691021 agcatttgct tggcttgttt accggaggag agaagaaaac atggcaggcg tccgggcagg 691081 atgaattcaa atggattgaa aagagatggc aggatctatc ccttgaaagc cggaagctcc 691141 aacagcagct cctgcggcag acgccccata tgaaaaagag ttttttgcag catctcttac 691201 agagcgattt ttactatgac aacgaggaaa gcctcagatt tcggatggag gaggctggct 691261 ggaacatcgg cggaaacgtg tttcatgtgc ttgatctaca ggtgacaggg ctccgctgtg 691321 aaaaaagcat cttccgtgaa ggtgatgaac agcttgccgt gtttacactg actaatatcg 691381 ctgaggaatt ggcggctaaa cgcgtttttc agctctccat acttgatatc ggccggcttt 691441 ctgtcaccgt tcttgtgatg aaaacaaaca gctctgatct gaaggcgtat ataacggagc 691501 tggcacgcca atttggagat gtaaccggac tatgcctgac ctcgacattg agcagcaaga 691561 cggagcgtgt cacggaaatt ccttctttat ttcaggatgt gaaatgcggc aaatcccgca 691621 ggaagtttgc taaccgggat caggtcattg atttgcaggc cgacttccct cgggatgagc 691681 agttcgctcc ttattaccct tttgagctgg aaaaacaaat tgttcagacc atccggctgg 691741 aaagaaaaca ggaagccaag gaactgatag atggatgtat gaaggaactg tcggaaaaag 691801 cggccataga caggcatgtg cattccgccc tgattcagct gttttcccgc attcaggagg 691861 atattttgca ttccgggctc aatcccagcg aactgtttca gcaccggaat ccgtttcttg 691921 atatttcaga attgcgcgaa cctaacgaag cggcggcctg gctgatggat gtagtggtga 691981 cgccttacct ttccaagctt gagggcagaa aaaacagaca gcaaaagcag ctggcagaac 692041 gtgtgattgc gatgattcac gaacagtata tggcggacat ttcattggaa agctgtgccg 692101 atgcgcttgg catgaattcc tatacgttaa gcaaggcatt taagcaagtg accggcatta 692161 attttatcga ttatgtgacc cagatcagaa tcgaaaaggc gaaagaactg ctggtcaata 692221 cgaataaaaa aattcatgat gtgtctgaag aagtcggcta tcgccacaat tatttcaatc 692281 ggatttttaa aaaacaggtc ggcatgccgc cgggtgtctt caggcaaatg tatcaggaaa 692341 cgccgtgaaa ggagagaaca tgtgatgaag aaaccgattc aagtattttt agcgggggat 692401 tccactgtga gtgactgccc gcctcatgaa gcgccgatgg cggggtgggg gcaggtattc 692461 gggcaattgt tttctgaagg tgtgctggtc cgcaatcatg ccaaaggagg agcgagcacc 692521 aattcttttg tggaggaagg aaggcttcaa gcaattgccg agcacatcac acaaggcgat 692581 tatttgttga ttcaattcgg ccacaatgac caaaaaccgc gggggacgaa gccgtactcc 692641 acatttcagc agtttcttac cttgtttgca gatacggcac gcgaaaaggg cgcgcatcct 692701 gtgttcgtca catcggtgca gcgccgccgc tttgatgaaa acggacggat cgagcatacg 692761 ctcggtgagt atcccgatgc gatgaaagca ctggcgaagg agctcgatgt acctgtgatt 692821 gatctgcttg cgaaaacaaa ggtgctgtat gaagcatacg ggccggagga gtcgaagcga 692881 ttgttcgttt ggtttcagcc gaatgaacat ccgaattacc cggacggcat tgaggacaat 692941 acgcattttt cggaaaaagg tgcaatggag gttgcgaagc ttgtggcaga aggcattgaa 693001 gagctcggac ttccgcttaa ggaccacctt gtgagccggg agggaaaaga acatgtataa 693061 ggaaggcgct tgcttgtacc gcaatccgct ccggtctaaa agcgatgtga aggattggcg 693121 gatggaggga ggcggacaga tctcatttga cgatcacagc ttgcacctgt cacatgtcca 693181 ggatgaagcg cactttgtct tttggtgtcc ggaaaccttt ccagacggca tcattgtgac 693241 atgggacttc tctccgatcg agcagcctgg actgtgtatg ctgttttttg ccgctgcggg 693301 tattcgcggc gaggatttgt ttgacccaag tctcaggaaa agaacaggaa cataccctga 693361 gtatcattca ggagatatca atgccctcca cctgtcgtat ttccgcagaa aatacgcgga 693421 ggaaagagcg ttccgcacct gcaatttaag aaaaagccgc ggtttccatc tcgccgcaat 693481 gggggccgat ccgctgcctt ctccagacga cgctgattct ccgtatcgta tgaagctgat 693541 caaagacaaa ggctatgtgc acttttcaat caatggtctg cccattcttg agtggatgga 693601 cgacggcagc acatatgggc ctgtgttaac aaaaggaaaa atcgggttcc ggcagatggc 693661 ccccatgaaa gccgtttaca gggattttgc cgtgcatcaa gcggtgagaa gatgaagacg 693721 actgtaacgg atgcgcttta tgcaggctgc gaagcggtgg tgaaaatagc atggctcaac 693781 gggctgtggc tgttgtttac acttttgggc ggcgttcttt tcggatgggc gccgagcaca 693841 gctgcgatgt gtgccgttat aaggaaatgg ctgatggggc aaaaggatgt cccgatattt 693901 tcgttatttc tcgataccta taaaaaagag tttctcaagg ttaatgcgat cggattggcg 693961 ttttcggctc ttttgctcat attgtctgcc aactatcatt atttttctgc cagtacgaat 694021 tggctgtcct ttgccgtaac aagctgcacg ctgcttgcag ggcttttgta tatcatcgcg 694081 ctgatgtatg tgtttcccct ttatgtgcat taccagctcc cgcttcgcaa atatattccg 694141 caggcactgc tgtttggcgc catgagaccg ctgacaactg gctgtatgct gatcgggtgc 694201 ggatttgtcc tttatttgct gtatacgctt cctggcctga tcccatttta cggcccgtgt 694261 ttatttgggc ttgtgttgat gttttttgct cttaggggat ttcaaaagac ggaggcccag 694321 caccatcaag ccgggtaaca aaaaaatgac aaataagcaa aaaagtgcag tgtccgaaat 694381 aggcagatgc aaaaaagtga aattgaagac agctcacaaa gcgcataaaa tccaatttaa 694441 gtaagcgctt acagataaat gagaaggagc tgtctgatga ttagacgaag gaaacgcatg 694501 tttaccgctg ttacgttgct ggtcttgttg gtgatgggaa cctctgtatg tcctgtgaaa 694561 gctgaagggg cagcgcggca gatggaagcg ctgaaccggg ggcttgtagc ggtcaagacg 694621 gacgggggca tttttgtcag ctggcggttt cttggaaccg aaaacgcatc tgttttgttc 694681 aatgtgtaca gagacgggca aaaactgaat gctgcgcctg tcaaaacaac gaactatgtg 694741 gataaaaacg gttcggcggg ctcaacgtat acggttcggg ctgttgtaaa cggtaccgaa 694801 cagccggctt ctgaaaaagc ctccgtatgg gcgcagccgt atcattccgt cccgctggat 694861 aaaccggctg gcggcacgac gccaaagggt gaatcttaca cgtacagcgc taatgacgca 694921 agtgttggcg atgtggatgg tgacgggcaa tacgagctga tcctgaaatg ggacccgtcc 694981 aactcaaaag acaattcaca ggatggctat acgggtgacg tgctgattga cgcgtataaa 695041 ctggacggca caaagttatg gcggatcaat ctcggcaaaa acatcagagc gggcgcgcac 695101 tacacccagt ttatggtgta tgaccttgat ggtgacggaa aagcagaagt ggcaatgaaa 695161 acggcagacg ggacaaaaga cggcacgggc aaagtaattg gaaatgccaa tgcagattac 695221 agaaatgaac aggggcgtgt gctttcaggc cctgaatatc tcactgtgtt tcaaggttca 695281 accgggaaag agcttgtcac cgcaaatttt gaaccggcgc gcggcaatgt gtcggattgg 695341 ggagacagct acggcaaccg tgttgaccgt tttctcgccg gcattgccta ccttgatgga 695401 cagcggccga gcctgatcat gaccagaggg tattacgcta aaaccatgct agttgcctat 695461 aacttcaggg acggaaagct gtcaaagctt tggacgctgg actcctcaaa gtcaggaaat 695521 gaagcgtttg ccggacaggg gaatcacaac ctgagcatcg cggacgttga cggggatgga 695581 aaagatgaga ttattttcgg ctcaatggct gttgatcatg acgggaaagg catgtactcg 695641 accggcttag gccatgggga tgccctccat acaggagatc ttgatccggg ccggccgggg 695701 cttgaggtgt ttcaagttca tgaggacaaa aatgcaaaat acggcttatc tttccgggat 695761 gctgcaactg gaaaaatcct ttggggcgtt tatgccggca aggatgtagg ccggggaatg 695821 gctgctgata ttgacccgcg ttatccggga caggaggtgt gggcaaacgg ttctctctac 695881 tcagcgaaag gggtcaaaat cggaagcggg gttccgtcct cgaccaactt cggcatctgg 695941 tgggacggcg atctgctccg ggaacagctg gacagcaacc gaattgataa gtgggattat 696001 caaaacggcg tatcgaaaaa tatgctgact gcatcaggcg cagcggctaa caacggcaca 696061 aaagcaacac caacgcttca ggctgatctg ctcggtgact ggcgcgagga agtggtgtgg 696121 agaacggagg acagcagtgc tctgcgcatt tacacgacga ccattccgac tgagcacagg 696181 ctgtatacgc tgatgcacga tccggtgtac cggcttggca tcgcctggca aaatatcgcc 696241 tataaccagc cgccgcacac aagcttcttt ttaggagacg gcatggcgga acagccaaaa 696301 ccaaatatgt atacgcctta actgaaaggg ggaaggaacg ggctgcgcgc agcccgttcc 696361 catcaaatga aaccaaaaaa gaggcaaatg gaatacctga ccagaggttt gattgcggta 696421 cagacagaac agggcgtgtt tgtcagctgg cgttttctcg gcacggatca tgagacgacg 696481 gcttttcacc tttatcggga tggaaagcgg atcacccgcg atccaatcgc tgaaagcact 696541 aattttctcg atcaaaacgg aacggctgac tctgtttatc aagtggcggc tgtcaataaa 696601 ggacgggaag aaaagctttc caagaaagct cgtgtttggc aggaaaatgt cctggaggtt 696661 cctcttgcca aaccggaagg cggtgtgacg ccggacggaa agccgtacac ttacagcgcc 696721 aatgatgcca gtgtcgggga tatagacggg gatggagaat atgaaatgat cctgaagtgg 696781 gacccgtcca attcaaaaga caacgctcat gacggttata ccggggaggt gctcatagat 696841 gcctataaac tggacggcac ctttttgtgg cgcatcaacc tcggcagaaa catcagagcg 696901 ggtgctcatt acacgcaatt tatggtgtat gaccttgacg gtgacggaaa agcagaaatc 696961 gccatgaaaa cagctgacgg cacaacagac gggaaaggac atatcatcgg tgatgagcag 697021 gccgatttta gaaacgaaca gggcagaatt ttgtccggtc cggaatattt gaccgtgttt 697081 aaaggagaaa ccggtgaggc gctcacgacc gtggaatatg aaccgccccg cggcaagctg 697141 gaggattggg gagacggcta tggaaaccgg atggaccgtt ttctcgccgg gaccgcttat 697201 ttggatgggg agcggccgag ccttgttatg gcgcgcggct actatacgag aaccgtgctc 697261 gtggcatacg atttcagaaa cggaaggctc aaaaaacgat gggtatttga ctccaaccag 697321 ccgggacatg aagcatacgc aggacagggg aaccacagct tgagcgtggc ggacgtcgac 697381 ggagacggaa aggatgaaat catatacggc gcaatggctg tcgatcatga cggaaccggc 697441 ctgtactcaa cgggcctcgg gcacggagac gcgatgcatg taggggatct ggacccgtca 697501 cgaaaagggc ttgaagtgtt ccaggtgcat gaggacgcca cgaagccgta cggactgtcg 697561 ctgcgagatg ccggaaccgg tgagatatta tggggcgtcc atgctggaac tgacgttggc 697621 cggggcatgg cggctcatat tgatccaagc tacaaaggat cgctcgtctg gggaattgat 697681 ccgccgggca atgatggcat gtcgtacggg cttttcacga gcaaaggcga aaaaatcagc 697741 gacaaagcgc cctcttcagc caatttcgcc atctggtggg acggtgattt ggtcagagaa 697801 ctgcttgatc atgactggga cggaacgatc ggcaggccaa agattgaaaa atgggatgct 697861 gaaaacggct gtctgaagac gatatttcag ccggccggcg tgttgtccaa caacggcacg 697921 aaaggaaacc cggttcttca ggccaacctg ttcggagact ggcgggaaga agtgatatgg 697981 agaacggaag acagcagcgc gctccgtatc tatacaacaa cacatctcac ccgccactgc 698041 ttttacacgc tgatgcatga tccggtttac aggctcggca tcgcctggca gaataccgcc 698101 tacaaccagc cgccgcacac gagcttttac ctcggaacgg gaatgaaaaa accgccgaag 698161 cccgccctgt acatagcggg aagcaaagcg gaggcgccgc tgtaggagga ctaagggata 698221 agacgcaaag gctgaacgct acgccaagat gattagagaa ctggcaggac gaaccaatgc 698281 tcaagcgctg tacgcaccgg ttttttcaag ggaagagcta tccgtgatgg aagctgtata 698341 aaaaacgagg aggaatgaaa aaatggcaaa tcatatttat cttgccggcg attcgactgt 698401 tcaaacgtat ggagacagca caaatcaagg gggctggggg cagtttctcg gctcgcatct 698461 gccggagcat attcaagtga tcaacagagc gatcggggga agaagctcga aaacatttgt 698521 ggaagagggc aggcttcagg caatcctcga tgtgattgag ccggatgatt ggctgttcgt 698581 gcagatgggc cataatgacg cgtcaaaaaa taagccggag cgctacaccg agccctatac 698641 tacttataaa caatatttaa agcagtatat cgcaggcgcg cgggaaaaag gcgcccatcc 698701 gcttctcatt acccccgtag cccgctttca ttacgaaaac ggcgtgtttt tgaacgattt 698761 tcctgattac tgcattgcca tgaagcagac ggccgctgag gagaatgtcc agctcattga 698821 tctgatggag aaaagtctcg ctttctttac tgagaagggc gaggaaaaag tgtacaccta 698881 ttttatgatt tcagaaggga ttaacgatta cacgcatttt acaaaaaaag gcgcaaatga 698941 aatggcgaaa cttgtggcaa aaggcataaa ggagctcggc ctgccattga cagaatcgat 699001 catcaaagaa aggtgaaaat gtgatgagaa aactgtatca tggcgcttgc tattatccgg 699061 aattatggga tgaagagacg attcagcagg acattgacat catgcgtgaa gttggcgtaa 699121 atgttgtgcg gatcggcgaa tttgcctggt cagtcatgga acctgaagaa ggaaaaattg 699181 acgtcggttt tttcaaagaa atcatcgccc ggctgtatga tagcgggatc gaaacgatta 699241 tgtgcacgcc gacgcctacc ccgccgattt ggttctcaca tggccggccc gaacgcatgc 699301 atgccaatga aaaaagagag atcatggggc atggctcccg tcagcatgcc tgtacgaaca 699361 acccgtattt ccgaaaaaaa gccgccatca tcaccacagc catcgccaag gagcttggcc 699421 ggctcccggg gctgatcgga tggcagctag acaatgagtt taaatgccat gttgcagaat 699481 gcatgtgtga gacatgcttg cgcctatggc atgactggct caaaaatcgc tacggggtaa 699541 ttgagcgctt gaatgaagct tggggaaccg atgtgtggag cgagacctat cagacgtttg 699601 agcaagtccc gcagccggga ccggccccgt ttctgcatca tgcctctcta cgcactatgt 699661 atcagctgtt ttcgatggag atgatcgctt cgtttgcgga tgaacaggcc aaaatcatcc 699721 gctgctattc agatgcgccg atcacgcata acggatcagt catgttcagc gtggacaatg 699781 agcgaatgtt tcagaatctc gattttgcct cctatgacac gtacgcttcg caggaaaacg 699841 cctctgcctt tttattgaac tgtgatttat ggagaaatct gaaacaaggg cgcccgtttt 699901 ggattttgga aacgagtccg tcgtatgccg cctcgcttga aagctccgct tacccgcacg 699961 cagacgggta tttgcaggcc gaagccgtat cgtcctacgc cttagggagc caggggtttt 700021 gctactggct atggcgacag cagcgttcag gcagcgagat ttcccacggt tcggttctca 700081 gtgcctgggg cgaacccacc atcggctatc aaaatgtgct ggcggttgag cgggcaagaa 700141 aggaaatcga gcctattatt ctatcgactg aacccgttca agccgaggcg gcgatgactt 700201 actctgacag agcaaaagca tttattaaaa ctgagcctca ccggggactc cggcatcgtt 700261 cgcttgtgac gcatttttat gaacgtattc tcaacacggg gattcaccgt gaccttattc 700321 cggaaggcgc tccactggac ggctatcgct tgctgtttac gccatttgtg ccgtatttgt 700381 cttctgaatt tatcaaaaaa gcttcggcat tcgctgaagc gggcggcatc tggatcaccg 700441 ggccgctgac aggaggacgc acatgcgagc ataccattca taccgattgc ggacttggcg 700501 aacttgagaa aacgtcaggg atcaaaacac tttttacctt tccgatgaat gagaacgtga 700561 atacaggaaa agcgtttggc atcacggcgc cgctcggact gtggagcgcg gtgtttgaca 700621 cagagagcgg aaacaccctt ggcacggttg aagcaggacc gggggcgggc catgcttttc 700681 tgacggaacg gaattacggc gaggggaaaa ttgtcatgct gggctcgctt ccatccggga 700741 aagaagggga tgcgatgctg gaagcgctcg tcaggcatta tgcggaggaa gctgttattt 700801 ccagccggtc ggatgtgaca cccggcacga tcgttgcccc gcgtataggc gaaaacggcc 700861 ttgtgtggat cgttgtgaat atggatggaa aaggcgggag cgtgacattg ccggaatcgg 700921 gaacggattt gttgacgcac cgcttggaaa aggcggggag actggcggtc ggaccgcatg 700981 aataccgtgt gattcaattt gacaatcaca gctgattctt tgtatcgaat cagctttttt 701041 ctatggaggg agagacagat gaaaaagatc aaatggttat caggacagcc aaaggtgaca 701101 agcggcgtga cgtggggcat gccatggaaa aaaggagaat taaaaaaagg agaccgtctg 701161 gcgcttatga atgaaaacgc ggaaacgcga tatgtgcaaa gcgaaccgtc ggcctattgg 701221 ccggacggga gcatcaagtg gacgaagcac gcggcggtgt ttggcggtca ggaaaaccaa 701281 agctttacag tgcacaaaag agaagtgccg cagccaactg aatcgctcag cattcttgag 701341 acagagcatg atatccaagt ggatacagga gcactcgttt gtaccattca taaaacagga 701401 tctgatttca ttcaatcatt gcagatcaat ggaaagccga tcgccgcagg cgggaggctc 701461 gttgcgataa gagaaacgag aaaagagtca gcggcgaaaa tggttctttt gcatgaaagg 701521 tctgtcagct ttatcaaacg ggcggcgatt gagcagagtg gtcctgtcaa agcagtagtc 701581 aaaatcgagg gagtgcatgt gcttcataaa acgtatgagg aatggctgcc gtttgtcatc 701641 cgattaacgt tttatgccgg gctgtctgag atcggccttg tgcacacgca gctgattgac 701701 aggagcggta aactagaatt cgttaagggg ctcggcatcg aattcgacct ttttttggag 701761 ggagagccgt acaaccgcca tttccgcttt gcgggagaga aagggatgta taaagaaccc 701821 gcccagctgt ttggcacacg taaattcaat gaacgatatc cgctttatga aaaacaaatc 701881 aatggcgaaa tgctgtctcc agatgaagag cataaggaat ggtttgcaca tggcacacag 701941 aatgcggttt gggacgatgt caagatcgtg caagattcca gcgatcatta cagcctgtca 702001 aaacggaccg gaaaagatta tgcgtgggtt ggaatgctgc atggcagccg ggcgaagggg 702061 ctctgctatg cgggcggaaa aaatggcggt gtggctctcg gcctgcggta tttctttgag 702121 aaatatcctt cagcactgga aatcacaggt cttgccggca gccgccccaa aatgactatc 702181 tggctttggc ctccggacgg cgaagcgatg gatttgcggc attatacagg aaacactcac 702241 gtggccagcg cgtatgaagg ctttgatgaa atgcgctctg atccgacagg cattgcgaac 702301 acaaatgaaa taagcctggc gtgcttttcg cacatgccgt ctgacgaagt cctcaatgcg 702361 ctggctgaca aatggcaggc gcccccgctc attgtatgcg agccggacgt ctattacgaa 702421 tcaaaagcac tcggggtatg gagcatcatt gacacatccc atccgctcaa aaaagagctg 702481 gaagaacagc ttgatgcggc ctttctgttt tataaaaagg aagtagagca acgcagatgg 702541 tacggttttt ggcattatgg cgatgtcatg catacgtatg acccgatccg gcatatgtgg 702601 cggtacgatc tcggcggata cgcatggcaa aacaatgagc tcgttccgac cctatggctg 702661 tggcaggcgt ttttccgctc aggcagagag gatatcttcc gaatggcaga agccatgacc 702721 cgccatacga gtgaaacgga cagctttcac ctcggtgaat atgccgggct tggctcacgg 702781 cataatgttg tgcactgggg atgcggctgc aaggaagcga gaatcagcat ggccgggctt 702841 cataaattct attattatct gacgggtgat gaccggacgg gagatctttt gacagaagtg 702901 aaggatgccg attatgccct tgtcaaaacc gatccgatgc gcgcttttta cgagaaaggc 702961 aagcacccga ctcacgccag aacgggaccg gactgggcgg cgttttgctc gaactggctg 703021 gcggaatggg agcggaccga aaattcggaa tatctcaaaa aaatcgaaac gggaatcaac 703081 tgtctgaagc ggctgccgct ccgcttatta tctggcccga catttgaata tgatccggcg 703141 acctcgatgc ttcatcatat gggagacggc attgcgggcg gatatcatat gatcattgcc 703201 ttcggcgcgc cgcaagtgtg gatggagctg gctgagcttc ttgatgactg ggaatgggag 703261 gatatgctga gtgaattcgg cgaattttac acactcagtg atgaggaaaa acgaaaaaaa 703321 agcggaggcg ctcttcatga cgggcatttt cactggccga tgttcgccgc cggtatgaca 703381 gcctacgccg caagaaaaaa gcaagatcct catctcgccg ccaaagcgtg gaatcttttg 703441 ctagaagata agctcagcca tacgccgctt ccgatcaaac cggagcgcat cgagacatgg 703501 acgcagctag aggagcttcc atgggtgaca acgaacactg tctctcaatg gtgtttaaat 703561 gtcatagcgg cgctggaact gatcggagat tcccttccgg caaaaaaaga aacatcgggc 703621 aaaaaaggat aacagccgga atttcatagg agaaatggtg caaaaaatga agattgcaag 703681 aatttatgta agcgctttat attgagaggg gcaaagggga aatgcaaatt gaaaaaaggg 703741 ggacttacgc aacatgaaaa taagaatgcg aaaaaaatgg atggccttgc cgcttgctgc 703801 catgatgatc gccggatgca gccattcgga aacatccaat tcagcaagcg gttcgaaaga 703861 tacgatcaaa attatggcgc cgctcttatc gccggaaagc ccaagtgata agagcccttc 703921 attaaaagcg ctcgaaaaat acacaggcaa agagattaag gtcacatggg tgcctgattc 703981 atcctacaac gacaaattca acatcgtcat ggcttcagga gagatgcctc acgcgattgt 704041 cattaaagat aagtcagccg gctttatcaa atctgtcaaa gcaggggcgt tttgggagct 704101 gtctccttat ttaaaagact acaagaattt aagccaggca gatgaaaaga ttttgaagaa 704161 cagctcggtg aacggcgagg tgtacggaat ctacagaacg agggatctga tcagggcgtg 704221 tatgatcatc agaaccgact ggctgaaaaa tgtcggtctg gatatgccgg aaacgcttga 704281 tgatttctat gaagtgctga aagcctttaa ggaaaaagat cctgacggaa acggcaagga 704341 tgatacgtac ggcatggtcg tgccgaaatg gatgggactc ggcaacggaa gcccatggga 704401 tgttctgcaa atctggttcg gcgctccgaa ccgctacggt gttgaaaacg gaaagctgat 704461 tccagatttt acaacgaagg aatacatgga tgcgctcacg ttttttaaaa agctctatga 704521 tgagggcttg atcaataagg actttgctgt catggattct gcgaagtgga atgatccggt 704581 tgtaaaagga aaagcgggtg tcatcgttga tacaggctca agagcgtctc aaatccaaag 704641 cgcgatggag gaggcggatg agtcgaacaa ggatatcatt gatatcgtcg gctcgcttga 704701 gggaccgaat ggcaagcgca ccttcccgac atctggttat tcaggcatga tcacgatacc 704761 aaaatcaagc gtcaaaaccg aaaaagagct gaaagaggtg ctgtccttcc tcgataagat 704821 gaatgataag gaagcgcaga ttctcacgaa caacggagtg aagggccgca attacgagct 704881 caaggacggc gtattcacct cacttgaaaa aaacaataaa tctctcctgt atgagcatga 704941 aggcttggca cagttcagca tgtcgattcc gaaaagcgag tattacatcg aagaccagaa 705001 aaccaagctc ttccagcatc gcaaggacat cataaccgaa ggagaaaaaa tagccgtctt 705061 taaccctgct gagtcgcttg tatctgatgt ctatacccaa aaaggagccc agcttgacaa 705121 catcatcctc gacgcgagaa cacaatttat cattggagaa attgatgaaa aagggttcga 705181 tgatgcggtg gagctttgga aaaaaagcgg cggcaatgaa ctgatgaagg acttgaacaa 705241 attgtaccaa tcgtcaaaat aaaccgatgc gcctgccttt cggcgggcgc cccggtatca 705301 cgaaaggaga acagatatgg aaacagtgcc gaagaagaga gatgcacctg ttctcaccgc 705361 tggaaaaggc atcagctgga tggctgcgct caaacgggac aaatggcttt atcttcttct 705421 tattcccggt ctgctttatt tcttgatttt caaatacttg ccgatgtggg gtgtgctgat 705481 cgcttttaaa gactattcgc catatctcgg cttctggaaa agcgaatggg tcggctttga 705541 ttatttcaaa gactttttta tgaatccgga ttttttccgg ctgctgcgca acaccctcat 705601 gctggcgagt ctggatcttt tgtttgcctt tcccgcgcct ctcattttgg ctctgctttt 705661 gaatgaggta agaaaggccg tgtataaaag atgtatccaa acctttattt acgtacccca 705721 ttttgtatca tggacaattg tggtcagcat caccttcgtt ttctttactg tcgatacagg 705781 tgtgatcaac aaattgatta tgagcctgac aggtgagcag atttctttct tgtcggatgc 705841 agactggttc cggccaatga ttgtgatgca aagcatttgg aaggagacag gctggggaac 705901 gattctattt ttggcagcgc ttgctacggt tgatcaagag cagtatgaag cggccatcat 705961 ggacggagcg gggcggttca ggagaatgtg gcatattacg ctgccggcga ttagaagcac 706021 cattatcgtt ttgttgattt taagaatcgg cagctttttg aatcttggct ttgaacaggt 706081 gtatttgatg acgaactcac tcaaccgcag tgtggctgac atcttcgaca cgtatgtgta 706141 catgatgggg attacccaag gggcgtatag ctacagcacg gcggtcggtt tgtttaaatc 706201 agttgtcggg attatcttga tttttggcgc caattacatt gcgaaaaagt ttgatcagga 706261 aggattgttt tagaggaggg agaggtatgg ctgaaattca cacgatgcac aacaccaaag 706321 ccggacgggt gtttgacgtc tgcaacattc tgtttctcgg cggtgtcggc gcgattacca 706381 ttttgccgtt tttatatatt atcgccggtt cctttgcgac agaagcggaa ctcgcccagc 706441 ggagcttctt tattttcccg aaaaccttta cacttgatgc ttacaagtat gtgttttcga 706501 caccgacgtt ccttcgaagc atgggcgtgt ccatcttcat cacggtggtt gggacggctg 706561 tacagctgtt ttttaccttc acgatggcgt atccgctggc gaaacggcat gtgaagggac 706621 ggaatctgct gttgaatctg gtgattttct ccatgctgtt ttcaggcggc atgattccga 706681 cgtaccttgt cgtaaaatca cttggccttt tggatacgta ttgggcattg attctgccga 706741 tggcgattaa tccgttcaac cttattatta tcaaaaactt ctttcagcag ctgccgcgcg 706801 agctggagga atcagcaaaa attgacggct gttccgaaat cggcgtcttc tggcggatcg 706861 ccctgcctct gtcaaagcca gttattgcga cctttgcgct gttttatgcg gtcgggattt 706921 ggaatgattt cttccacgct ctcttatata tcaatgacag tgcaaaatgg ccgctgcaaa 706981 tggtgcttcg ccaagtcaca attttatcgg atttaacggc gaccaatggt gatacgatgc 707041 aaaatgcagt tccgccggag cagggaatta aactcgctgt cattgtcatt gcgacgctgc 707101 cgattttggc ggtctatcca tttttacaaa aacactttgc aaaaggaatg ctgatcggtt 707161 cggtgaaagg ctgagaaagg gagtgtttca tatcagtaca ttagatcaga ttaagattgc 707221 ctatatcggc ggggggtccc aaggctgggc cagaagcctg atgagtgatt tgtcgattga 707281 tgaacggatg tcaggcacgg tggcgctcta tgatcttgat tttgaagccg ctcagaaaaa 707341 tgaagtgatc ggcaatcaca gcgggaacgg cagatggaga tatgaggctg tttctacttt 707401 gaaaaaggcg ttatcagccg cggatatcgt cattatttcc attttgccgg gatcactgga 707461 tgatatggaa gtcgatgtgc acttgcctga gcgctgcggt atttatcagt ctgtaggtga 707521 tactgtcggg cctggaggga tcatcagggg cttgcgtgct gtgccgatat ttgcggaaat 707581 tgcccgggca ataagagact acgcacctga atcatgggtc attaattata caaacccgat 707641 gtctgtctgt acaagagtgc tgtataaagt gtttcccggc atcaaagcga ttggctgctg 707701 ccacgaggta ttcgggacgc aaaagctatt ggcggaaatg gtcacggaaa ggctggggat 707761 tgaggtgccg cggcgtgagg atatccgcgt taatgtgctc ggcattaacc attttacatg 707821 gatcacaaaa gcctcttacc gccatattga cctgttgcct atattccgtg aattcagcgc 707881 gcactatggg gaatcaggat atgagctgga gggggaatgc tggagggaca gcgtcttttg 707941 ttcggcacac cgtgttgcgt ttgatttatt tgaaacgtat ggcgccatcc ctgctgcggg 708001 tgacaggcat ctggcagagt ttcttcccgg cccatacctc aaacagcctg aagtatggaa 708061 atttcatctc acacctatat cattcagaaa acaagacaga gctgagaaac gacaagaaac 708121 agaacggttg atcgtgcaac aacggggcgt tgctgagaaa gcttcgggag aagaaggcgt 708181 gaacatcata gcggctcttc tcggattggg tgaactcgtc acaaatgtaa atatgccgaa 708241 tcaaggccag gtcttaaacc ttcctataca agccattgtc gaaacaaacg cattcatcac 708301 aaggaaccgt gtccagccga ttttgtccgg agcgcttccg aaaggtgtgg aaatgctggc 708361 ggctaggcat atatccaatc aggaggcagt ggcggacgca ggtttaacaa aggatactgg 708421 cctcgcgttt caagccttcc tcaatgaccc gcttgtccag attgaccgca gtgatgcaga 708481 gcagcttttc aatgacatgc tccaatgcat catgcaaagc tgagcttgcc gattagctct 708541 ttccggttta gaaaggaaag cattgaccat actgatagta taatcaagaa gtaggtgcta 708601 tcaatatggg aaattattta agtgttgcgg tagaactggt ctgcggttta ggcattttat 708661 ttatcatctt aaagcttctc gggaaaaccc aattttctca aattacgccg tttgacttta 708721 tttctgcttt aattttaggt gaattggtcg gaaatgccgt ctacgatcat gaaatcaaaa 708781 tcaaagaaat tatttttgct tcgctattgt ggggcgtgct gatttatatt attgaattta 708841 tcacgcaaaa aatgaaatca tcgcgaaagt tcttggaggg cgagccgaat atcgtcatcc 708901 gcaaagggga gcttcaatat aaagtaatga agaaaaataa gatagacatt aaccagctgc 708961 aaagcctatt gaggcaagct gggagctttt cgatccaaga agtagaatat gcgattcttg 709021 aaacaaacgg gatggtcagc gtgcttccaa aatcagactt tgacaaaccg acaaataagg 709081 atttgcagat tccttcgaag tccgtttctc tgccgatcac gttaatcata gatggagaga 709141 ttgtgcggga taatttgaag gaagcaggtg tggatgaaca gtggctgaaa caagaattga 709201 aaaagaagaa cattgataag acagaggacg tgttatttgc agaatggcat aaaaataagc 709261 cgctgtatac tgtaacgtac gaacaaagca gatcaacatg actcttagaa aaaagcttgc 709321 agcaaggcgc aagcttttta ttgattgtat gtcccttgtt tgacagcacg tacatggtac 709381 atgctcactt cagtgctgat cagatagtca ggctttggtt tgcctttgtt tgctttatgg 709441 ccggcgatat gcgcatcgct tttttcccat tgcttccagt gatcctctga ttcccagcga 709501 atcatgacaa caacttcttc atcaccgcgg cgcacatttt tctcaagcac tgtcacatca 709561 attaaacctt cttgtttttc aatgattcct tcagcgctga aacgttctat gactttatct 709621 gcaaagcctt ctttaaccgt catttttctc aactgtacaa acatttgtct cactccaatc 709681 attctcacat atgaataatt gtaaatgaaa ttcattctca atgtcaaaga aagcgcaggg 709741 cggaatcgaa ccgccgtgcg caacagttta ttcttttaat aaaaacacat ttccgtcttc 709801 gtccttaaat tgaacgaagg tgccccactc catttgattg ggctcaccga gaaattctac 709861 accgtttgtc ttcattttct cgtatgtacc aaagatgtct tcgcattcaa acacaataga 709921 agccttcatt tgctctgagc ctttcatcat ggctttcggg taaatgacta aacgagtctc 709981 ggctcctttt ggcgcaacct ccagccagct tgcttcaggt cccattgggt gatccgctgc 710041 aatatcaaag cctaccttct ctgtccaaaa ttgcttcgct ttctgctggt cctcgacata 710101 tacagcaaca gtgccaattt gtttgatcat agggaaacct ccaagttgaa aagataataa 710161 tactataacc tgtttacggc cgaagtaaca taaaaaaatc agccgggaaa ccggctgatt 710221 attaaaatga gcagcttaca acatcgatgt gatttgtgtc taaggcgaaa taaacccagc 710281 ggcgccgtga ggaatcccaa taaaagccgc cgacggatct tctgccaagg atgatcgggt 710341 aaaaccaaaa tgagcggcca ttggttaacc agacataggt aaatcggaaa aggcaaggac 710401 gaatggtgat tggttcaact aacaaaacgg ctccttgaga accctgcggt tttgggggtt 710461 tcgctggtat ttgggaagga ggaggtccct gcggcgcacc gccgaagcct gggctggcac 710521 cgctgccaat accagggccg gagccgccgc caaagcctgg aacagcacca ccgccaatgc 710581 caggaccgga gccgccgcca gagcccggaa cagcgccgct gccaatgcca ggccatggat 710641 atcggtattc atattcaaaa gcaggccaag gctcataaaa atgccccgca aacatataag 710701 gatcaacata atacatgtga taacgtcctt tctcattgta aactgtacat tgcagtttat 710761 gcgggcggac tcttattggt gcattcgcct aaggatatga agctggaatg ctctcagaga 710821 gcagaatcat ttgatttttc tctagtctta ttcacaattc cgatttatca ttttataatg 710881 aaagtgcttc tattacgaaa aaggagacag accgtgaata tcgatcaatt attatatcaa 710941 tatatcatag acaacactgc ggatattact gagaaatggt tcagtttgcg ttgccagcta 711001 aaaggcgagc tatattccgc cagccattta agtgaagaaa cgaaaacact tttaaccgag 711061 cagcatacat ttaccaatat aacaatcgca agcgcatttc tggaggatca aaccgatttt 711121 caagaaaaca tgacaaaatg ggcgcaaaac gttgcgaaaa acagggtaga gcaggatgtt 711181 caagtgcatg aggtcgtaga agccatatcc aattcaagaa tctcattctg ggacgcagtc 711241 gccacattta taaaagagaa tcaggagatt gtgacaaatg aggatgcaga ccgatggaac 711301 cgcattgtga atcagtcgtt cgataagctg attattgaat tctccgagca gtaccaaaaa 711361 ttcatgctga tgaggcttac atctcagcag gaactgatct cagagcttgg ctgcccggtc 711421 atttccattg ccgatggaat cgggatattg ccgcttatcg gctccattga tacaaaacgg 711481 cacaggtcat tttagaaaca gtgccggtcc gctgtgtcga gagaaaaatc acaagcctcg 711541 tcgttgatct ttcgggtgtt ccgattgtgg ataccatggt ggctcagcaa ttgtacaacc 711601 tgtctaaaac acttttctta ttaggcgtca aagccgtatt ttcaggaatt cgcccggatg 711661 tggcccaaac atcgattcaa ttggggcttg attttagtga atatgaaacg tacggcacgc 711721 tgaagcaggc attagaaaac atgggtgtcc gctgtattgt tgaggaattg gaagaaaaca 711781 aataggaagt ttccaggcat atgattgtcc gtcaccgggt gatcatatgc ctttttgatt 711841 tgaacagaaa tcaccattga tttatcgaaa aaaacataat attataattc ttataagaat 711901 actgtgaatt aaaacctatt caacaggggg gaaggtcttt tggtttctaa atcaacgatt 711961 gatccggaag tgattgaaaa aatcatcagc tcgctggaaa cactcgattt cggcacggtt 712021 cagattacgg ttcatgattc tcagattacc caaattgaga aaatagaaaa gcaccgtttt 712081 tcgctgaaaa ggaaagaatc aaaatgataa tgtaaagggc gtttgttttc attaaattct 712141 ccttaaaaca tatacatatt tcatccaatt tttatataat agacctttaa gatcattttt 712201 taggaggatt tttgacatgc aagctacggt tcacgagagt aagcaatcga tcatgcaacg 712261 cattttgaca gtctttgtct tcacattgct gatcgcgact gtcggccttt ttatcggcca 712321 atttgttcct gtcgctttga tgctgccgct ttctattctt gaagtggcga tgattattct 712381 ggccttctgg atgcgcagaa gaaaagcggt cgggtatgcg tttgtatata cattcgcgtt 712441 cgtttccggc attaccttat ttccgatcgt cagccattac gcttccatcg ccggcgccta 712501 tgtcgtgctc gaagcctttg gctctacatt tgtcattttt gccgtcttgg gcacaatcgg 712561 cgcaaaaatg aagaaggatt tatccttcct gtggtcgttt ctgctggttg cggtgctcgc 712621 actcgcagtg gtagggattt tcaacatttt cagcccgtta aactcagcgg cgatgatggc 712681 gtattccgtg atcggaacca tcgtcttttc cctttacatt ttgtatgatt tgaaccaaat 712741 caagcaccgc cacattacgg aagacttgat tccggttatg gcgttatcgc tgtacctaga 712801 ctttatcaac ttgttcatca acctgctccg cttcttcggc attttgagca gtgatgatta 712861 atgaaaaagc gtctgtcatt ggataggcgc tttttgccat acatcaaaaa ggcaggtgga 712921 gtattggtga aaaaacaaat gggcgcatat gtatctctgg cagcagctat ggcgatcgtc 712981 ggcagttctg tcgttgtcgg caagctgatg gtcgaacgga ttccggtctt tctttcctca 713041 ggattgcgtt ttttgatcgc ttctgtcgta ttgctcatgc tgctgttttg cattgaaaaa 713101 gggtttccgg ctttgacgaa aaaagatgtg ttcgtattac tggtgcaatc attcacaggc 713161 gtgtttttgt tcagtatttg cctgctgtat ggggttcaat atacgacggg aacggaaagc 713221 ggcattttga caagcacaac ccccatgttg atcggtattt tatccttttt cctgctgaga 713281 gaaaaaattg agaaaaagac gctgatcggc attttgctgg cggtttgcgg cgtaatggcg 713341 attaatttgt ttggagccgg gagccaagac gggacgccgc acgccttatt cgggaacatg 713401 ctgatcattg ctgcagtcat tggcgaagcg ttgtttacat tgatggccaa gctgctatcc 713461 ccgcatattt cggcactggc gatttcgacc ttcgtatcgc tcttcggctt cctgtttttt 713521 ctcccgtttg ctttgtttga ggcctcttca tttgattaca gcgtgccgac tgttttggat 713581 tggtcgtatg tgctgtatta cgcgcttttt gtcactgttt tggcgtttta cttatggtat 713641 agcggggtga cgaaggtgcc ggcgggtgta tcgggcattt tcacatccgt tcttccggtc 713701 tcagctgtca ttttgtcagg cgtgatattg aaggagccat ttgagtttgt gcatttcatc 713761 ggcattgcat gtgtcatcgg cggcatattt gttacggtca taaagaaaaa acagccggat 713821 gcgtatccgg ctgcagaaga aaagacgcta tagcctgtcc ggatcggacg ggttttttag 713881 tctttaaaca cgctcagcct ttcaaaaaga tcaccaagca tcttcacgaa catgtctttt 713941 tcctcgtcgc tgtagttttc catgacagcg gatattttgc tgaaatggcc gggcagaaat 714001 tgctccaggc gtgctttgcc ttctgttgtc agttcaatgc tgatttttcg tttatcctct 714061 gtgtgatgcc tgcggctgac aaaaccgtct ctcgccagcc cgtctagcag gcctgtaatt 714121 gttgctttcg tgacatttga ccgcttggca agctctgtcg gacttaacct atgatccttg 714181 gcatcaaaga gcagcatcag gattttgaat tttccttctg aaagccctcg gccagcaaag 714241 taatgctcca tcacatgatt catttttttt gaaatatcaa aaagagataa aaacaattca 714301 agagagccgg cgtcaatatt ggcatacgtt tcggcgtgct ctgttatatg cttatatttc 714361 ggtaaatgtt ttaattccat cgcaattagc tcccgtacat tcgttgtgac acgattataa 714421 aggagggaaa accataacgc aacttggctt ggagatgatt gacagctttt cttgggacat 714481 agtaaggtaa tatagttagg cgcctaacta atacatatag agctgaaaag gtggttattg 714541 atatgaaaca tatgttaata gcaggaggcg gaatcggcgg cttgtcagcg gccatttctc 714601 tccgtaaggc agggttttcc gtcaccttat gtgaagcggc ttcagaaaat cgaaaaacag 714661 gtgcggggat tcttcagccg caaaacgcac tggcggtgtt gaaagaactg ggcgtattcg 714721 aagattgctg taagcacggc tttcaaacag aatggtttaa aacgtttgat gaacagggga 714781 atttgctgtt tcaagtcagt gaatcctttt tagacgattc acttccggga cgcaataata 714841 tcctgcgcaa aacgttaaat gacattctca tgaagcatgc cgaggcagtg ggtgtagaca 714901 tcaagtgggg gaaaaaggtt gtcgcctatg aagaaactgc tgaatcggtc actgccttat 714961 gtgaagatgg agaaaagatg caggctgaca ttctggcggg ctttgacggc attcactccg 715021 ttgttcgtga taagatgctg caaaaggaaa cggaaaaaga gcatctcggc atgggagcgt 715081 ggcgctttta tatcgaactt cctgattaca cattcgagga cgcaacattc atgtatagaa 715141 gcggagacac acaaatcggg gtggtgccat tggcacaaca cgctggctat gtcttcgtcc 715201 tccagccttg cacgagcgat tactgggatg aggaagatac ccggtttgat agagtaaaag 715261 agattctttc tggttttcgg gggctggatt ttgtcacaaa gcacatgtca aaacagcatc 715321 ctgtcatctt taacaaactg gagcaggtcg ccgtgcagga gccatggcat aaaggccgcg 715381 tcatcatcgg aggagacgcc gcccacgccg gtgcgccaac cctggcacaa ggagcggcaa 715441 tggcgatcga ggatgccatc gtcctcgccg aagaactcca aaaccacgcc gaccacgaaa 715501 cagcattaca ggcgtactat aaaagaagag ccccacgagc gctcaaagtc cagaacctat 715561 catctgaaat cgtccgccgc aggctgaaag gagagccggg agcggaagaa ctgattgggg 715621 agtgctatgc ggtgttgagg gaagggtatt aaataggaaa agtccagaaa gtgatttctg 715681 gactttttag tcttgctctg ttttattcct tatccgctca atcacctcat gcagcccctc 715741 aggcttataa aactccaccg gtgaactgcc tttctcaaac gaaatcgtct cggcttcaat 715801 cagcgcgaca tagcgcccgt ttacttttgc gagatgaata gaatcgccaa aatccgctag 715861 caatccctta atctctgttt ctccgacttt cattttcagc tgggcctctg gcgtgtgctc 715921 gatgatttgg gcggaggctt cgatgacttg atgggtgtcg aggcgctctt ggatttcccg 715981 tttttcgctt gcttcccaaa tctcaatgtc gtgctcgaac tgcttgagtt cttcgctgtt 716041 gtcttcaaat gtctcgtaga cgtgctcttg taccatgttc atgacctgat ttttcatgat 716101 ttctggcatc gattctccgt actcgacgaa tttcagaaag tcctcaaaat agcgggcgtg 716161 cgaggcctgg tggattttca gttcaccttc ctcgaccatt ccttcctctg gcatgtacgg 716221 gtattggatg cttttcatgt tttttgtcgt gatcgccatt tcgacttttt taatgagaga 716281 agacgcgtca gagatgcggg cgaccttcgg ctcaaaatca catttcataa tgaagacaaa 716341 tgactcatca aagtattttc tcggcacggc cgaagcgacg agaaacacgc cgccgcgaac 716401 cgcgcttgtg tcaaggtacg tgcggacgaa ctgctcgctc agctcattga agtcttcttt 716461 tgtttccgcc agacgcgcgc ggttgaacat gttgtagttt gggttggaat cgagctcgtg 716521 gccgggctcg acgataaaat ggccgatttt cgtcggcacc tgctcggact gcggatggcg 716581 gtcggctttc cgtttaacga tttttttcag ttccccgtcg agaaagtcct tcagctcgct 716641 ttcttcaaat tctcccgtat caagggtctg gaagtgcttg aactgcttgt tcgcctgctc 716701 atctttgcct tccacctgta tgacataaaa ggataaaaac cgaatttcaa aatccatata 716761 taaactcacc ttattcgcgt attgtacagc ttctcaagta tagaaaaaac agcgatcatg 716821 cgtcaattgg gagaacggaa taatcatgac catgaaaggg aaatgtagtc aaatagaagg 716881 catttcatac ggaaaggaat ggttcgatga aggaaacaag cccgattcct cagccgaaga 716941 cgtttgggcc gctcggcaat ttgcctttaa ttgataaaga caaaccgacg ctttcgctga 717001 tcaaactggc ggaagaacag ggcccgattt ttcaaatcca tacacccgcg ggcacgacca 717061 ttgtagtgtc cggccatgaa ttggtgaaag aggtttgtga tgaagaacgg tttgataaaa 717121 gcattgaagg cgccttggaa aaggttcgcg cattttccgg tgacggattg tttacgagct 717181 ggacgcatga gcctaactgg agaaaagcgc acaacattct gatgccgacg ttcagccagc 717241 gggccatgaa ggactatcat gagaaaatgg tcgatatcgc tgttcagctc attcaaaaat 717301 gggcaaggct caacccgaat gaagcagtcg atgtcccggg agatatgacc cggctgacgc 717361 tcgacaccat tgggctatgc gggtttaact accgctttaa cagttactac agagaaacgc 717421 cccacccgtt tatcaacagc atggtgcggg cgcttgatga agcgatgcat caaatgcagc 717481 ggcttgatgt tcaagataag cttatggtca gaacaaagcg gcaattccgc tatgatattc 717541 aaacgatgtt ttcgttagtc gacagcatta ttgcagagcg cagggcgaat ggagaccagg 717601 atgaaaaaga tttgctcgcc cgcatgctga atgtggaaga tccggaaact ggtgaaaagc 717661 tcgacgacga aaatatccgc tttcagatca tcacgttttt gattgccggc catgaaacaa 717721 cgagcggcct gctttccttt gcgacttact ttttattgaa gcatcctgac aaactgaaaa 717781 aggcgtatga agaggtcgat cgggtgctga cggatgcagc gccgacctat aaacaagtgc 717841 tggagcttac atacatacgg atgattttaa atgaatcact gcgcttatgg ccgacagctc 717901 cggctttcag cctttatcca aaagaagaca cagtcattgg cggaaaattt ccgatcacga 717961 cgaatgacag aatttctgtg ctgattccgc agcttcatcg tgatcgagac gcttggggaa 718021 aggacgcaga agaattccgg ccggaacggt ttgagcatca ggaccaagtg cctcatcatg 718081 cgtacaaacc attcggaaat ggacaacggg cctgtatcgg catgcagttt gcccttcatg 718141 aagccacact tgtgttaggc atgattctaa aatatttcac attgattgat catgagaatt 718201 atgagcttga tatcaaacaa accttaacac ttaagccggg cgattttcac atcagtgttc 718261 aaagccgtca tcaggaagcc attcatgcag acgtccaggc agctgaaaaa gccgcgcctg 718321 atgagcaaaa ggagaaaacg gaagcaaagg gtgcatcggt catcggtctt aacaaccgcc 718381 cgcttctcgt gctgtacggc tcagataccg gcaccgcaga aggcgtcgcc cgggagcttg 718441 ctgatactgc cagtcttcac ggcgtaagga caaagacagc acctctgaac gaccggattg 718501 gaaagctgcc gaaagaggga gcggttgtca ttgtgacctc gtcttataat ggaaagccgc 718561 caagcaatgc cggacaattc gtgcagtggc ttcaagaaat caaaccgggt gagcttgagg 718621 gcgtccatta cgcggtattt ggctgcggcg accacaactg ggcgagcacg tatcaatacg 718681 tgccgagatt cattgatgag cagcttgcgg agaaaggcgc gactcggttt tctgcgcgcg 718741 gggaagggga tgtgagcggt gattttgaag ggcagcttga cgagtggaaa aaaagcatgt 718801 gggcggatgc catcaaagca ttcggacttg agcttaatga aaacgctgat aaggaacgaa 718861 gcacgctgag ccttcagttt gtcagagggc tgggcgagtc tccgctcgct agatcgtacg 718921 aagcctctca cgcatccatt gccgaaaatc gtgaactcca gtccgcagac agcgatcgaa 718981 gcactcgcca tatcgaaatt gcattgccgc cggatgttga atatcaagag ggcgaccatc 719041 ttggcgtatt gccaaaaaac agccaaacca atgtcagccg gattcttcac agattcggtc 719101 tgaagggaac cgaccaagtg acattgtcgg caagcggccg cagtgcgggg catctgccat 719161 tgggccgtcc tgtcagcctg catgatcttc tcagctacag cgtcgaggtg caggaagcag 719221 ccacaagagc gcaaatacgt gaactggcgt catttacagt gtgtccgccg cataggcgcg 719281 aattagaaga actgtcagca gagggtgttt atcaggagca aatattgaaa aaacgaattt 719341 ccatgctgga tctgcttgaa aagtatgaag cgtgtgacat gccgtttgaa cgatttttag 719401 agcttttacg gccgttaaaa ccgagatact attcgatttc aagctctcca agagtgaatc 719461 cgcggcaagc atcgatcaca gtcggtgtcg tgcgcggccc ggcgtggagc ggccgtggcg 719521 aatacagggg tgtggcatca aatgatttag ctgagcgtca agccggtgat gatgtcgtga 719581 tgtttatccg cacaccggaa tcccggtttc agcttccgaa agaccctgaa acgccaatta 719641 ttatggtcgg gccaggcacg ggagtcgcgc catttcgcgg tttccttcaa gcccgcgatg 719701 ttttaaagcg ggagggcaaa acgctcggtg aggctcatct ctattttgga tgcaggaacg 719761 atcgggattt tatttaccga gatgagcttg agcggtttga aaaagacgga atcgtcactg 719821 tccacacagc cttttcccga aaagagggca tgccgaaaac atatgtccag catctcatgg 719881 ctgaccaagc agatacatta atatcaatcc ttgaccgcgg tggcaggctt tatgtatgcg 719941 gtgatggcag caaaatggcc ccggatgtgg aggcggcact tcaaaaagcg tatcaggctg 720001 tccatggaac cggggaacaa gaagcgcaaa actggctgag acatctgcag gataccggta 720061 tgtacgctaa ggatgtctgg gcagggatat agataaagaa gactggagac atccagtctt 720121 tttagtcctt tcgaaaaaat ggtgatcgcg ctaaacattg atgcatacaa taacttcagt 720181 ccgccggaag ggcgggctgt ctgcaaaacc tatttttcgt ttttgctagt ttatgttatt 720241 cttatactcg gtatctattt cttttttcaa aggcacacat gacaaaagaa atcctttttt 720301 tatttccgag aaaaaaatgt gaaacgaaat gaaggtttct ttcgtccagt gattggtttc 720361 caaatggttg taataaaaat gatatggtgc gaaacataaa tattccggct tgccgcggtg 720421 tatttattgt tgtgtgatgc cttgattttg tttggaaaga aggaattgga aggcaggata 720481 taaagagcag gtaaatatga atgaagaact taaagtgttt aagaaagtag aggttgccat 720541 gaagaaactt ttttcttaca aacttagctt ttttgtgctg gctgttatac tgttttgggc 720601 aaaaacgtat ttatcctaca agactgagtt taatcttggg gtaaaaggca caactcagga 720661 gatcctcctg atatttaacc cattctcaag cgccgtcttc tttttaggac tggctttgct 720721 ggcgaaaggg cgtaaatcag ccattattat gctgattatc gatttcttga tgacatttgt 720781 gttatatgca aatattttat tctatcgttt ctttgacgat ttcttgacgt tcccgaacat 720841 taaacagtcc ggaaacgttg gaaacatggg agacgggatt ttcagtatca tggccggtca 720901 tgatattttc tatttcttag atattatcat tttgattgcg gtattgatct ggagacctga 720961 attaaaagaa tacaaaatga aaaaacgctt tgcatcttta gtgatccttt ctgggatcgc 721021 actgtttttc atcaacctgc actatgcgga aaaagaccgt ccgcaactgc tgacaagaac 721081 gtttgaccgc aattatattg tgaaatattt aggtttatac aactacacca tttatgacgg 721141 tgtacagacg gctcaaacag agacgcaaag agcctatgca agcagcgatg atttaacaag 721201 tgtcgagaat tacacgacgt ctcattatgc gaaaccaaac gccgagtact tcggctctgc 721261 caaaggcaaa aatatcatta aaattcacct cgaaagcttc cagtcattcc tgattgacta 721321 caagctaaac ggtgaagagg tgacgccttt cttaaataaa cttgcgcacg gcggggaaga 721381 tgtgacgtat tttgataact tcttccatca gacaggccag ggaaaaacat ctgatgccga 721441 gctgacaatg gataactcga tcttcggtct tcctgaaggc tccgcgtttg tgacgaaagg 721501 cgaaaacacc taccagtcgc ttcctgcgat tttagaccag aaggaaggct atacaagcgc 721561 cgtcctgcat ggtgattaca aatcgttctg gaaccgtgac cagatttaca aacatatcgg 721621 atatgacaag ttcttcgacg caagcacgta tgatatgtca gatgaaaatg tgattaatat 721681 ggggcttaag gataagccgt tctttacaga atcgattcca aagcttgaat ctcttaaaca 721741 gccattttat gcgcatttga ttacattgac aaaccattat ccgtttaacc ttgatgaaaa 721801 agacgcgtct cttaaaaaag cgacaacagg cgataacaca gttgacagct acttccagac 721861 agcgcgttac cttgacgaag cgcttgagca attcttcaag gagctgaagg aagccggcct 721921 gtatgacaac tcagtcatca tgatttacgg tgaccataac ggtatttctg aaaaccataa 721981 ccgagcgatg aaagagattc ttggaaaaga gatcacagat tatcaaaacg cacagaacca 722041 gcgtgtgccg ctgatgatcc gcgttcctgg caaaaaaggc ggagtgaacc atacgtatgg 722101 cggcgaaatt gacgtcatgc cgacacttct gcacttagaa ggaattgatt ctcagaaata 722161 tatcaacttt ggtactgatt tattctctaa agaccacgac gatacggtgg cattcagaaa 722221 cggagacttc gtaacgccga agtacacatc agtcgacaat atcatttacg atacgaagac 722281 aggtgaaaaa ctgaaagcga atgaagaaac gaagaatctg aaaacaagag tgaaccagca 722341 gctgagcctt tcagacagtg tcctgtacaa agacttgctg aggttccata aactaaatga 722401 tttcaaagcc gttgatccgt cagactatca ttacggcaag gagaaagaaa tcaaataaga 722461 tgaaaaagag ccttgagcgg gcgcattgcc ttcgctcaag gctctttttt tggttataca 722521 accaacttga aaaaatagat tccatttggt caccaaggct ggctttctct catatcatta 722581 cagtagattt tgaaaccgga ttgaaatcgg acaaattatc ggggaaatgc cttgatagat 722641 tgtgaagatg taccaggttt cgaactcaat attcatagag atgaggggta gagatgaaag 722701 cggtcattct ctgcggcgga aaaggaacga gaatgagtga agtcacgaat gacattccta 722761 aaccgctcgc catgataggc ggcaaaccga ttctatggca tattatgaaa atttatcagt 722821 actacggagt aaacgagttt attctgcttt tgggctataa aggagaaaaa atcaaggaat 722881 actttctcga ctatgaatgg aagcacaaca gcctgacact cgacagctct acgggagagg 722941 tacagatgct ggggcagcct gaaacgtgga aaattacgtt tttggagact ggggtagata 723001 cgctgacagc cggaagaatc ttgcaggcga aagactatat cggtgatgaa acatttctgc 723061 tcacctatgg agacgggctg gccaatatca atcttttcca tctcatcagc tatcatcaga 723121 caaaaggtgc tgccgcgact gtcaccggca ttgacaaagt ctcgcagttt ggcaccttga 723181 cagttgagga tggcatggcg aaaacatttt ctgagaagac atcaagtgat ggaatcatca 723241 acggcggatt cttcgttctt agtccaaagg ttttcgatta tttgccgaag gacgggaaca 723301 cgatgttcga agatgaaccg ctgaagaacc ttgccaaaga tggggagctt gctgtgtacc 723361 gccattacgg attttggacg gccatcgata cgtataaaaa tctcttagaa gtcaacaaaa 723421 tgtggaatca aggacaacaa gtatggaagg tatggtgaat tgatttgagt ttctggaaaa 723481 ataaaaacgt atttgtcacg ggatgcacag gtcttttagg aagctatttg gtgaaagagc 723541 tgatcgaaca gggcgcaaac gttacggggc tagtcaggga tcatgtgcct caatccaatc 723601 tttatcaggg agaacatatc aagaaaatga acatcgtgcg gggctctctt gaggacttgg 723661 ctgtgattga acgcgcgctt ggcgagtatg agatcgacac agtctttcat cttgctgcac 723721 aagcgattgt cggcgtggca aaccgcaacc cgatttctac ctttgaagcg aatatcctcg 723781 gcacctggaa tattctcgaa gcctgccgca agcatccgtt aattaagcgg gtcattgtcg 723841 cttcaagtga taaagcttac ggcgatcaag aaaaccttcc atacgatgaa aacatgccgc 723901 tgcaaggcaa gcacccgtac gacgtctcaa aaagctgcgc agatctgatc agccacacct 723961 attttcacac gtacgggctt ccggtctgca ttacgcgctg cggaaactta tacggcggcg 724021 gagatttgaa cttcaaccgc atcattcctc agacgattca gcttgtgctg aacggggaag 724081 cgccggaaat ccgaagcgac ggcacatttg tacgggacta cttctatatt gaagacgccg 724141 ttcaggctta tctgcttctt gcagaaaaaa tggaagaaaa caatcttgcc ggagaggcct 724201 ttaacttcag caatgagatc cagctgaccg tacttgaact ggtagagaaa atattaaaga 724261 aaatgaacag taatctgaaa cctaaggtgc tgaatcaggg aagcaatgaa atcaaacatc 724321 aatatttatc cgcggaaaaa gcaagaaagc tgctgaattg gacaccggcc tacactattg 724381 atgagggact tgaaaaaacg attgagtggt atacggaatt cttcaaaaag taatgtgaaa 724441 cgaggtgaac aagactgtga ccagcgcgta ttgcaccgtt ttatcaaaag gaagattata 724501 tcaggcagtc gctttgttta agtcgttaga gcaagttgat caagacagtc ccatttttat 724561 actttgcatg gatgaagata cgcaccgcgt gttacagaag ctgaagatga agcagctgaa 724621 ccttgtgccg gtggccgctc ttgaaaatga attgctgctg aagctgaagg aaactagaga 724681 tcaaagtgag tattgctgga cgatgaagcc gatctttctg caagctgtgc tgaacagcaa 724741 tcctgagctg gagcgtgtga cgtatattga cggggatctc tttttctatg cagatccatc 724801 gccgattttt gaaaaccagc cggactgctc ggtgttgctt tcacgagggg atattgtaat 724861 cccttctttt gagaaagagc agattgacat gctgcagcgt cttttaggca gatataattc 724921 cgggtttatc agcttcaagc atgatgatgc aggcacggat tgcttggagt ggtggaagga 724981 acgctgtctt gaggaatgca aaaatgcacc gggtgaaggg aaattcggtg atcagggcta 725041 tttggattat atgtctgagc tgtttccgaa tgtgtgtgac attacaacac ccggcgtgaa 725101 catcggccat tggaattatg gacagcatac gttttcctgg aaagatggcc ggatcgtgct 725161 ggaggatggc agtccgctga tcttttatca tttcagcgga taccgaatcg tcagcatcaa 725221 tgaaatcaaa cagattcatg aaacaacccg cacagatctg ccgtttgtgc atgaactgta 725281 tcaagagaca ctgccgcata tcattcagca catgcaaacg ttagaccctg aatttaacgg 725341 ttttgcttca aaagatgaca acaaataaat gagtaaatac aggaagtgaa aatgaagtga 725401 aagcaagcgt tattattcct gcatataatt cgaaggagcg tctttacaac agccttctgt 725461 cattaaacca gcaggagtgc gatgaagaat ttgaagtcat tgtagcggac aatggctctg 725521 aggacgggac gctctcgatg cttgagtcat ttcaagctga ttttccgctg atctttacac 725581 ggattaaaga aaacaggggc attgcgtacg gacgaaatca ggcgcttcgc aatgccagag 725641 gagacatcct gattttccat gacagcgata tgcttgcggc aaaggacctt gtggcaaaac 725701 atattaaagc ccatgagaac gaagagaatc tcgtcgtgtg cgggttgttt tggaaacgga 725761 tctacagttt ttactatgaa cgatttgaag aagaacataa ggaacagctc gcaaagctca 725821 caggtgaaat gccgaagaaa gacaaacaaa agctgctgga ggaagcggac atcaaaaacg 725881 gaagctttct tgataaaagc tttgacctcg ataccgactt tatagacgtg ctcaagaaga 725941 ttttagatga gtacggcgat gacttgaaag gctatcatat gccatggcgc ttttttatca 726001 cgaataattc ctctgtgaaa cgcaagcatg tggttgacct cggtttattt gacgaaggca 726061 ttgtgcggta cgggtttgag gattatgacc tcgggatcag gcttcatcag gccggattga 726121 ccttcaggct tcgccgtgat attgtcagtg ttcatcagga acatccaagc aattgtaagt 726181 ctgtagacga tattcgggca aacattgcct atatgtgcga taaatacaat aacatccgct 726241 ccttagacgt tcatctcgct tttaatgggc cgttcccgcc tgacatgacg aacagaatca 726301 tggctgatat tcaaaagctg ctggaatcac agaaatatga tatgctgctg aatctgtttc 726361 ttgagcttct gcatgttgtt aaagagcgca acattgatcc ggattggcga aagaaatccc 726421 caagggtgac ggcgaaaagc tttgatttgc aaactgtccg caagcttctg cctaaggcga 726481 agaaaaagct aggcgtgaac gattttgcca acgcactgta tgcgcttgtc aacgatttgc 726541 tgcacgtgga tcttagatca ttggatgtgg tataagtgag tacatttcat ttttcaacga 726601 tagtgtcaag gacacatatc tttaagctca tgcctatgat tcattctctc catgagcatt 726661 gcgatgattt tcatttatat gtgctgtgtg tcgaccagaa agcgtatgaa ttgcttcagc 726721 acgttccatg ggagcatgta acctttgtgc agctgcatga aatggaagac ccggagctgt 726781 tgaaagcgaa aagcaacaga acgtttcatg aatattgctg gacgttaaag cccgcctttt 726841 tgtttcatgt gatgagcaag tgggatgacg ctgaatactt tgcccatatg gatacggatc 726901 tatttttctt ttctgatccg gcacgtattt ttgcagaaaa cccaacggcg tctctgtatt 726961 tgactgatca tcgtaattcg ccgcgcttca tgtcctacta cgaccgaacc ggacgcttta 727021 atacaggctt tgtcggcgcc ggtaatacaa aggaagcata tgaagcggtg tggcagtgga 727081 gacaggactg tattgaattt tgcacggtcg aaatggatac ggaacgaaag acatatggtg 727141 atcaaagata tgtggagaaa tggccggagc agtttaaagg tgttcatgtt gtcaaatcca 727201 taggagccaa tacagcgctt tggaatatcg aaaactataa ggtcgggcaa aaggacggcc 727261 gcgtgtatat agatgaaacg ccgctgattt tctatcattt ctctgggttt acgctggtga 727321 cagaaaaaga gtttaatctt tgctggtact accggattga agacgaagcg acaattaaga 727381 tgatttatat gccctatata ttaaatctga aaagatggat tgatgaaata cagtcggcgt 727441 ttccggactt tgcggatggc tttatcccga agcacgcagt gcctgacact cattttatcc 727501 agctggatta aaaaaccccc tgccgcctgg caggggtttt ttcagctatg ccattctctc 727561 agcttctggt cacttggcaa taggaaggca aggatgccga ggacagggag aaaggcaatg 727621 gcgatcatcg tcggggtcag tcccgcggca tcaatcagag cgcccagcgc cacagcgccg 727681 attgcgccca tcccgaaggc aagcccgacg gttaaaccgg acattgtgcc gatttttcca 727741 ggaactagct cctgtgcgta gacgaccgtt acagaaaagc tcgacatcag aaccaagcca 727801 atcaatgcga gcacgccgta ggcgagaacc gggccggcaa atggcagcac aatcgccagc 727861 ggcgccgagc ataacagcga accgaggata acgaagcgtt ttccaaaacg gtctgcaagc 727921 gggccgccga gaaacgtgcc gatcgcgccg aacagcaaga agacaaaaat atagctttgt 727981 gcctgctgaa tgcttacgtg ataggtatcc atcgcgtaaa acgtgtaaaa gttaccgatc 728041 gcactcgtat accaagaacg agcaaaaatg agaaatataa taataataag agcagataca 728101 acagatttgg tgatggccgt gttttcagcc gttttctttt gcttgcctga tttctgggca 728161 aggctgccga gacgtgaggc gtaccatttc gcaatataca tgagaaacat aacagcaagc 728221 gcggcgacaa gcgtgaacca aacagcgccg aattgcccga gcggcacaag gatcagcgcg 728281 gtgatcagcg gtgccatcgc ctggcctgag tttccgccca cctgataaat cgattgggcg 728341 agcccgcgtt ttgtgccggc ggccatatac gccacacggg agccctccgg atggaaaatg 728401 gccgagccta atccaatgaa aaacacacag cataagatcg ttatgaatga cggggcaaat 728461 gcaaggccca aaatgccaag catgctggcg gtcaaaccga ctggcagcgc atacggccgc 728521 ggccgtttat cggtatacca gccgacaaca ggctgcatga cggatgacac catgtttaat 728581 gtgaaagcaa tgatgccgag ctgtgtaaac gtcaggctca tggagcgttc caaaataggg 728641 aacatggccg gaatcacagc ctgaagcgaa tcgttgagca tatggcaaat tccgataata 728701 atcaaaatcg gatacaccgt ggtgcctggt ttttgaactg ttttttcttt taacggggcg 728761 gcgatagcca ttgagtctcc tccttacata tataaccaaa gcataccacc atattattca 728821 taaggtgaag aatttatcaa gaggaaaaaa gattcttatg aaagaaatac cgtcagcctg 728881 attagcagct gacggtattt tcgatattca aaatgtgata tagctcttca agcttacgaa 728941 tctcataggt tggtatgatc tctggcacat tcggcttcat gtcagggttc atccagcaag 729001 tatcaagccc ggcgagctgt ccgcctttga tatcagcagt tagtgaatcc ccgatgatta 729061 atgtgtgctc tgctgaaaat tgaggaatcc gttcaaacac gtaattgaaa tattccttca 729121 tcggcttttg gaagccggtg tcttcagaaa cgaaaatgtc cttgaagaat ggaaataatc 729181 ctgaatcacg gagacgctta tattgtgtgt gagacacgcc gtttgtcacg atgtacaaat 729241 caaactgttg ctgcagattt gagatgagat caaatgcacc gtcaataagc tgatgtcctt 729301 cttcaagaaa gcggcggtat ttttgctcaa gcaaagcgcc gtccgcttcg taaccgtact 729361 ccttgagcaa agcggaaaaa cgtgtgttta cgacttcatc ccgtgtcatc ttaccttctt 729421 caaaggctct ccagagacct tgattgatgg ttttatactg cgccttcatg tcatttgtta 729481 aaggaatgtt ctgatcttca aacagcaaac gcagggctaa agcttctgcc gcttgaaaat 729541 caaggatggt atcatctaca tcaaataata aagtgcggta tcgcttcatc tgtgtgtctc 729601 cctttctcat atgtattcaa agtatagcac ataaaaaaag gaaaaagccg gcgggtgagg 729661 caccgccggc tgaaaagaga ttatttgttt aataagctgt gttttctcga atataggaag 729721 taaaccagcg ttccgacagc gatccagatg acaaatgaaa gccatgtgac gccgggaagg 729781 ctgtacatga accaaaggca gatgcctgcg ctgataatcg gcacaaccgg aacgaatggc 729841 actctgaagg acgctttgat ttcaggatgt ttctttctta acacaatgac agcaatggaa 729901 atgaccgtaa acgcggcaag tgttcccatg ttcaccagat gggccagcgt tccgaggtta 729961 ataaagccgg cgattcccgc tgcaacgatc cctgtcagcc atgtgttgcg gaacggggtt 730021 ttaaatgacg gatgaacctt tgcgaacaat ccaggcagaa ggccgtctct gctcatggca 730081 aatgtcaagc ggacctgtgc gtacagcaaa gcgagcatca ccgtcgtaat cccgataatc 730141 gcaccgacag aaataattcc ggcaacagcg tcctgtccga cgaatttcag cgcaaaggat 730201 acaggatctc cgacattcaa tttggcataa ggcatcatgc ctgtcagcac aagcgatacc 730261 gcgatgtaca gaaccgtaca gacggctaga gctgaaataa tgccgacggg catgtttttt 730321 tgcggatttt tcacttcctc tgatgcgtta gaaaccgcgt caaacccaag gtacgcgaag 730381 aatacagtgg cagcgctaag tatgacgcct ttcatcccga atggcataaa aggagaccag 730441 ttatccggtt tcacatagcc gatgccgaca ataatgaaca ataatatgat cgcgattttc 730501 atcagtacga tgacgttgtt aaagcgtgtg ctttccttga cgcctctgct gacaatcgca 730561 gtgatgagga gaatgatcac cgcagccgga aggttaaata cggcgcccgc catgcttccc 730621 ggcgctcctg tcagtgcagc cggaatatga agattgaagc cggcaagcag tgattgaaag 730681 tatgaagacc agccggtggc aaccgccgac agtgcaatga catattcaag catgagatcc 730741 catccgatca aaaaggcgag cagctctcca agtgtcacgt atgagtatga gtacacgctt 730801 cccgaaatcg gaatggaaga cgaaaactca gcataacaga aagcagccag cgcacaggcg 730861 agccccgcta aaataaacga tatgatgagg gcgggacctg caccggtcgc tgccactgtt 730921 cctgtaatga caaaaatccc tgtaccgatg acacaaccga taccgagcaa ggttaaatca 730981 aatgcgctta acgtacgggc aaggcttttt gacttgctct gcgcactcaa tgtttcaagc 731041 ggtttttttc taaataatga actcatcaaa agttcctcct agaaatattc aaaatattct 731101 aatcattata tgcagttctt gttgtattat attgtcgaaa tttgacgtag tcaataaaat 731161 atttttctgc tttaaatgat agaagcgaaa cagcgttgtc gtatcatagg atagtaattt 731221 ttactaatcg tatattcaat tttatgcaag atgaaccgat agaaaaaata gattcgccca 731281 tattttgatt tgcggttata aaggagatgc tgaccatgtt tcaatatgaa gagttgaata 731341 aacagtttat cggcgggaaa tggcaggagg gcagcagccc aaatgtattg gaaaacaaaa 731401 atccttatac tcaaaaaaca ttcacaacat tccgtaaagc gactgctgac gatgtagatg 731461 aagcgtatcg ggcagcggcg ctggcaaaga aaaaatggga tgcggtcaac ccgttcgaga 731521 aaagaaccat tttagaaaaa gccgtcacgt atattgaaga aaatgaagaa gccattattt 731581 atttgattat ggaggagcta ggcggtacaa ggctcaaagc agcttttgaa atcggtcttg 731641 tcaaaaacat cataaaagaa gcggcaacgt tcccaatccg catggagggg aaaattcttc 731701 cgtcaacaat agatggcaag gaaaacagat tatatcgcgt gccggcaggc gttgtcggtg 731761 tcatcagtcc gtttaacttc ccattctttt tatctatgaa atcagtggcg cctgcactcg 731821 gagccggcaa tggcgttgtg ctaaagccgc atgaggaaac gccgatttgc ggcggaacgc 731881 tgattgcgaa aatttttgag aacgcgggaa ttccagcggg gctgctgaat gttgttgtca 731941 cagacattgc tgaaatcggc gacagcttcg ttgagcatcc agtgccgcgg atcatctcat 732001 ttaccggttc tacgaaagtc ggcagctaca tcggacagct tgcgatgaag cattttaaaa 732061 agccgcttct tgagcttggc gggaacagcg ccttcatcgt acttgaggat gcagatatag 732121 aatatgcggt caatgcggcg gtgttcagcc gatttacaca tcaagggcag atttgcatgt 732181 cagccaaccg cgtgcttgtt cattcttcta tttatgacaa gttccttgag ctgtaccagg 732241 caaaagtgga atcgctgaaa gtcggcgacc caatggaccc tgatacgatt atcgggccat 732301 taatcaacag cagacagacg gacgggctga tgaagactgt agagcaagca attgaagaag 732361 gcgctgtacc agtgaagctt ggcggattta acgggacgat cgtggaaccg acgatcttaa 732421 aagacgtcaa accgttcatg agcattgcca aggaagagct gttcggacca gtcgtctcct 732481 ttatgaagtt tgattcagaa gacgaagcgg tggatatcgc aaacgaaacc ccgtttggct 732541 tgagcggtgc cgtacatacg tcaaatcttg agcgcggcgt ggcttttgcg aaacgcattg 732601 aaacaggcat gattcacgtc aatgacacga ccatcaatga tgaaccgaat gtagccttcg 732661 gcggtgaaaa gcaatcaggc ctcggccgtt taaacggtga gtggagcctc gaagaattta 732721 caacgctgaa atggatctcg gtccagcacg aaaaacgcag cttcccttat taatgaaaag 732781 gagtgaatgg aattgaccat aaatacggaa aaagaaaccg cagatattct ggacgcattt 732841 atcaaagtag ccccttattt aaacagcctg gttcaggatg atattacaat cggcatttat 732901 gatacggaaa aactgctcgt gaatataccg gccaaaacct tttcgctgaa cgtaaaagcc 732961 ggcgatccgc tgcaggaagg ggatatcatc acagatgcca tccgcagcaa tcagaagaag 733021 acgagcatgg ttccgaaaga attgttcggc ttcccattga tcgcgcgtgc catcccgctg 733081 cacgacgaga atggaagagt cattggaggc gtcggcctcg gaacgagcct tgaggagtcg 733141 tcaaagctgc atgatgtcgc ggaaagctta tcagctgttg ttgaacaaac agccgcggct 733201 atttccgaca tttctgaatc aattaacggg ttttcaactc aaatgtcggg catttcctct 733261 caggcgaaaa aagtaagcga aagcgccggt gaaatcgccg atatttcagt aactgttaaa 733321 ggcatctcgg accaaagcaa tctgctcggc ttgaacgccg cgatcgaagc ggcaagagca 733381 ggggagtccg gaaaaggatt ctctgtcgtc gcagatgaga tcagaaagct agcgacgcat 733441 tcaaaagaaa atgtcggcca aattgaccag attacgaaaa aaatccacag cctgctgaaa 733501 gggctggagg aatccattga gtcgattaac cagcatacag acggacaagc cgctgctgtt 733561 gaacaaattt ccgccacgat gcaggagatt tcaggaagcg cgcagcatct tgcgaaaatg 733621 gccgaaaaag cgcttgagga agagtaagag accggggaca aacatccccg gtctttttct 733681 tatcctgcat ttccatgaaa ttcgtctgac gttttactag ttttattcca gcggctgatt 733741 taaaatgtac acatgaactt acgtgaggat tgataggaac catgagcata ttaaaagcgg 733801 aaaatcttta taaaacatac ggagataaaa cattatttga ccatatctcc tttcatattg 733861 aagagaatga gagaatcgga ttaatcgggc cgaacggaac aggaaaatca acgctgttga 733921 aagtgattgc cggcttggaa tctatcgaag aaggagaaat cacgaaatcc ggaagcgtgc 733981 aggtcgaatt tcttcatcaa gacccggagc tgcctgcggg gcaaacagtg ctggagcata 734041 tctattccgg tgaatcggct gtgatgaaaa ccttgcgtga atatgaaaaa gcgctgtatg 734101 aactggggaa agatcccgaa aatgaacagc gccagaaaca cctgctggca gcacaagcga 734161 aaatggacgc gaacaatgca tgggatgcaa acaccttggc aaaaaccgta ttgtctaagc 734221 tgggcgtcaa cgacgtaaca aaaccggtca atgagctctc aggcggccag aaaaaacggg 734281 tggccattgc caaaaactta attcagcccg ctgatttgct cattttggac gagccgacaa 734341 accatttgga taatgaaacg attgagtggc ttgaagggta tttaagccaa tatcccggcg 734401 ccgtcatgct ggtgacgcac gatagatatt tcttaaaccg tgtcaccaac cgcatttatg 734461 agcttgaaag aggcagcctc tacacttaca aaggcaacta tgaagtgttt ttagaaaaac 734521 gcgcggaacg ggaagcgcag gctgagcaaa aggaaacgaa gcggcaaaac ctgctgcgcc 734581 gcgaactggc ttggctcaga cgaggagcga aagcccgctc cacaaaacaa aaagcgagaa 734641 ttgaccgggt agagacgctt aaagagcaga caggccctca gtcatcaggt tcactcgatt 734701 ttgccattgg ctcgcaccgt ctcggaaaac aggttattga agcggagaac gtcatgatcg 734761 cttatgacgg ccgcatgctc gtcgaccgtt ttaatgaact tgtcatacca ggtgaacgga 734821 tcgggatcat cgggccgaac ggcatcggga aaacaacgct gttaaatgcc cttgccggcc 734881 gtcatacgcc ggacggaggc gatattacga tcggacagac ggtcagaatc ggctactata 734941 ctcaggatca tagtgaaatg aacggtgagt taaaagtcat tgactatata aaagaaacgg 735001 cggaggtcgt aaaaacggca gatggcgata tgattacagc tgaacaaatg ctcgagcgtt 735061 tcctcttccc gcgttcgatg cagcagacgt atatccgcaa gctgtccggc ggggaaaaac 735121 gccgtttata cttgcttcag gttctcatgc aggagccgaa tgtcctgttt ctcgatgagc 735181 cgacgaacga tttggatact gaaacattaa gcgttcttga ggattatatt gaccagttcc 735241 caggcgtcgt catcaccgta tcccatgacc gctatttcct tgaccgcgtc gtcgaccgtt 735301 tgattgtatt tgaaggaaat ggtgtcattt cccgctttca aggctcctat agcgactata 735361 tggaggagtc aaaagcgaaa aaagcggccc caaaaccggc agctgaggaa aaaacggctg 735421 aagccgagcc gaagaaaaaa cggaaaaagc tttcttacaa agaccagttg gaatgggacg 735481 gcatcgaaga taaaattgcc cagctggaag aaaagcatga acagcttgaa gctgacatcg 735541 ccgcagcagg cagtgatttt ggcaaaatcc aagagctgat ggccgagcag gcgaaaacgg 735601 cggaagagct tgaggctgcg atggaccgct ggacagaatt gtccctcatg atcgaagaac 735661 tggaaagcta aaaagcgtgg ccgcagcagg ccgcgctttt tttcacataa tggacaaaaa 735721 cgaaccggcc tgcttatgtt aggataaagt tgtgtgtcag cggcacatgg aaaactaacg 735781 gagatgatga agtatgacat gggcgatcgt gatgttaatt ctcatgagtc tggtgaaaat 735841 cgtattaacc tgtcttccta caggcgtcat agaatggctg ctcggcaaat ttgaagtgca 735901 cgccaagctg agtgacgaaa atgcgagtct ctctctagat ggaaaacgcc tcgagggtgc 735961 agagaagcag aaagtgattg atcaatttaa cgaagctatc ttcctggaaa aatattatat 736021 ctatccaggt gatgaagagc gttatttaca tccggaaaac ggcggcacgc ctctggtgat 736081 agatacaaaa aaaggaaaaa aagacgtgaa gctgttcgtg taccgctacg acgaccatat 736141 cgacgtcgtg aaacagtaca agaagaaagt gatcgcgtat cgagtgcttt ctgaaagcct 736201 tcaaaaagag tctctgtcag tggcgggaag tttagcttaa acaggaaagt gaaagacggg 736261 tgctgtatgc tgctcgtctt ttttattgtt ttttaaaact taacgtttac gttaaggttc 736321 aaaaggtgta taatggtaac agaaacggcg aagggggatt taccttggaa tggatgaaga 736381 ttgatcaagt ggccaaaaga agcgggctga caaagcggac catccggttt tatgaagaaa 736441 tcggcttgat tccggcgccg aaacggacag acggcggtgt aaggctttat tcagaggatg 736501 atatggagga gcttgagaaa gtcatcagca caaaagaggt gctcggtttt tcccttcagg 736561 agcttcagca tttcatggaa accagccgcc agctagagtt aaacaaagag gggtatttgt 736621 tgtcactgga tcctaaggaa cggaaagaaa aactggagga aattcaggaa accctgaatc 736681 accagctgga tttgattgat gagaaaatcc gcacattcca aagctttaaa gaacgcctgc 736741 agggcatgaa aggcaaagcg gaacgcgcca ttcaatcaat cgaatgaaaa gtttgttaaa 736801 cgctattttt gtagcgtttc ttttaatgga ataaagatgg aggttaggtc aaatggataa 736861 gacaacacaa gtgaatcaga aaacgggttt gctcagccag ccaaaagcgg tatgggctgt 736921 cgcgtttgcc tgtgtgattt cttttatggg aatcgggctg gtcgatccaa ttcttccggc 736981 cattgccgca caattgcatg cttcacctag tgaagtatca ctcttgttta caagttattt 737041 gcttgtaacc ggatttatga tgtttttctc aggagccatt tccagccgca tcggcgcgaa 737101 atggacatta attctcggac ttatttttat tattgtgttt gcggggcttg gcggcagctc 737161 aagctcaatc gctcagttag tcggctatcg cggcggctgg ggattaggga atgctttgtt 737221 tatttcaaca gcgcttgcgg tcatcgttgg cgtgtcagtc ggcggcagcg cccaagcgat 737281 tattttgtat gaggccgcgc tcggtctcgg gatttctgtc gggccgcttg caggcggaga 737341 gctcggaagc atttcatggc gcgcaccgtt ttttggagta tctgtcctga tgtttattgc 737401 gttaatcgcg atttctttca tgcttccgaa gctgccgaaa ccggcgaaac gcgtcggtgt 737461 gtttgatgcg atgaaggcac tcaaatataa aggcctgctg acaatggcgg tatcggcatt 737521 cctatacaac tttggatttt ttattttgct agcttattct ccgttcgtac tggatttaga 737581 tgaacacggt cttggatatg tcttcttcgg ctggggcctt ctgctggcga ttacgtcagt 737641 ctttacggcg ccgctcgtgc acaaagcgct gggcacagtg cgttcgctag tcgttctctt 737701 tatcgccttt gcggccattc tcgttattat ggggatctgg acagaccatc agactttgat 737761 tattacatgt atcgttgtcg ctggtgctgt cctcggtatg gtgaatacga tcatgacaac 737821 cgctgtgatg ggttctgcgc cggttgaacg ttcaatcgcg tcttcagcct acagctcagt 737881 ccgcttcatc ggcggcgcgc tcgccccgtg gattgcagga atgctgtcag aacactttac 737941 tgcaagcaca ccatatacag taggcggaat cgtcgttttt gtcggcatgc ttgtccttct 738001 catgggacgt aaacatcttg ctggaattaa ggcggggcat taataacgaa agacactgcg 738061 catatgcagt gtctttttat tcgttataat gcatcataat cgaattggtg caggaaagga 738121 caacctttat gacacaattt tactattttc cggctgaaaa ctccctttag aaaccggttt 738181 tttcggtcag caagaacggc gttcgcggaa agggcatccg cttcggtcag gcattgatgc 738241 ggctgggatt tatcttgcag aagctgagaa tgtgtccgtt catttacgat tgccatttca 738301 gtgatggttc atgctgtaga ggggacgttt gccatggata aggcaaaacc tgacgaatat 738361 gatcagaaat gtttagaaac gctctatcaa tacatacaca gcgtcatgaa aaacagcttt 738421 tctcggtcga gtggtttacc gcttgggaag atgaggagga ttttgagctg tctgccaaaa 738481 gagagctgac acttgatgaa ttcacatctc cattgcagct cattttaaaa gacagagagc 738541 ttttgagaat cgttcagaaa aaatggcagt aaaaaacccg ccctttagca ggcgggtttt 738601 tttataaatt aaagcacttt cgtcgtccaa gactcgcagt tccacgtttc tgtcgcaata 738661 tccatataaa agtctggctc gtgggaaatg agcagaatgg agcctttata ttctttcagg 738721 gcgcgcttga gctcttcctt ggcatcggca tccaagtggt ttgtcggctc atcgagcacc 738781 agcaggtttg tttctgagtt gattagcttg cacaatctga ctttcgcttt ttcgcctccg 738841 cttaatacgg agacgcggct ttcgatatgc tttgtcgtca gcccgcattt tgccagagcg 738901 gcacggattt catactgcgt ataagaaggg aattcgctcc atacttcttc gatgcacgta 738961 ttgttgtttg tttccttgac ctcttgctcg aaatagccgg tatagatgtg ctcaccgcgt 739021 tcaacagagc cttcgagcgg ctggatttca ccaagcaaac ttttcagcaa tgtcgttttt 739081 ccgatcccat tcgcgccgta aagggcgatt ttttggccgc gctccatgcg gaggttgagc 739141 ggacgggaca gcggggaatc gtaaccgatc acgagatcct tcgtttcaaa aatcagcttg 739201 cctgacgttc tcgccggctt aaagtggaat tccggctttg gcttttctgc cgcaagctcg 739261 atcatatcca tcttatcgag tttcttttgg cgggacatcg ccatgtttct cgtgctgaca 739321 cgcgctttgt tgcgggcgac gaaatccttc agctccgcga cttcctgctg ctgctttttg 739381 taggccgctt caagctgctg ttttttcacc tcgtagactt ccataaactg atggtagtcg 739441 ccgacataac gtgtcagctc ttgattttca acgtgataaa tcaggttgat gacactattc 739501 aagaacggaa tatcgtggga aatcaggatg aacgcgttct cgtattcctg caggtagcgt 739561 ttcagccatt caatatgctg ttcatcaaga tagttggtcg gctcatcgag aagcagaatt 739621 tccggctttt caaggagaag cttagcgaga aggacctttg tgcgctgtcc gccgctcaaa 739681 tcggtgacat ctcgctctaa accgatatcg ctcaaaccga gaccgcgggc gatttcttcc 739741 accttggaat caatgacata aaaatcattg tttgtcagcg cgtcttgaat gacgccgact 739801 tcttcaagca gcttctcgag ctcgtcggga tcagcctcgc ccattttgtt gtaaatctcg 739861 ttcatttcct cttccatcgc aaataaataa tggaatgcgt ctttcaggac gtcgcgaatg 739921 gattttcctt tttccagcac ggtatgctga tcaaggtatc cgacacggac attttttgac 739981 cattcgactt ttccctcatc aggttcaagc tttccggtaa taatattcat gaaggttgat 740041 tttccttcac cgtttgcgcc gatcaagccg acgtgctcgc cttttaacag gcggaaggaa 740101 acgttattaa aaatggcccg gtccccgaaa ccgtggctta aatcctttac agataaaata 740161 ctcatgttta cacctctatc gttatcaaac acgcacaatc ggcgtgtaat attcaccctt 740221 ttgattataa aggaggattc ggaatgttga aaggtatagg aaagaaaaag aaaaattgcg 740281 ttccgggcga ggttttgaga tactatggaa tagatttcag gaattgagga gaacaaaatg 740341 acgcaaactt ggccattttt acataatgca caatcattta tacaagagaa ttggaatgct 740401 tccggctttc aaaagccaac ccctgttcag gagcaggcag cccagctgat catggacgga 740461 aaggatgtca ttgcagaatc gccgacaggc acagggaaga cgctggcgta tgcgctgccg 740521 gtcttggagc ggatcaaacc agagcaaaag catccgcagg cggtgatttt agcgccttcc 740581 cgtgagctgg tcatgcagat ttttcaggtg attcaggatt ggaaagcggg ctcagagctg 740641 cgcgcggctt ccttaatcgg cggggcgaat gtgaagaaac aggtcgaaaa gctgaagaaa 740701 catccgcata tcatcgtcgg cacgccaggc agggtgtttg aactgattaa agcgaagaaa 740761 ctcaaaatgc atgaagtgaa aacgatcgtg cttgatgaaa cggatcagct cgtcctgccg 740821 gagcatcgcg aaacgatgaa gcaaatcatt aaaacaacat taagagaccg ccagcttcta 740881 tgtttttctg ccacgctcaa aaaggaaaca gaggacgtgc tccgcgaatt ggcgcaagag 740941 cctgaggtgt tgaaggtgca gcgaagcaag gcggaggcag ggaaagtgaa gcatcaatac 741001 ctgatttgcg accagcgcga caaagtgaag ctgctgcaaa agctgtcaag gcttgaaggc 741061 atgcaggcac tcgtatttgt gagagacatt ggcaacctga gtgtatatgc ggaaaaactg 741121 gcatatcacc acgttgaact cggcgttttg cacagtgaag cgaaaaaaat ggagcgagcg 741181 aaaatcattg ccacattcga agacggagag tttcctcttt tattggcgac tgacattgcc 741241 gcacgcggtt tagatattga aaacctgcca tacgtgattc atgctgatat tccagatgaa 741301 gatggctatg tccacagatc aggacgaaca ggccgggccg gaaaagaagg caacgtgctg 741361 agccttgtga caaaattgga ggaatctaag ctgaaaaaaa tggcgaagaa gcttggtgtt 741421 gagctgagtg aagctgtgta tgcaggcgga aaactgaaga cgaaataaaa agaagggcga 741481 agagcccttt ttttgttgta aaataataga aaagattttg cgcggaggtg ggaaaatggc 741541 ttcaatagac aggtttcaag taatgcagga gccagagctg aaaatccttg aacactggtt 741601 tgagaatgag gataccagac ggagaatgga tgggatgctg ctattagatg agtggtatgc 741661 acgagtaaat aaagataaac acgatactgt catcatggcg tatgatggac agctgccggc 741721 agggatggtc gttattgagt tcggagagga gcggacatat attggattga tcgtcaatcc 741781 tttgtaccgg cttaaagggt atggaaaaca gatactgcaa aagctgatga ccgaacctga 741841 ttttactagc gtgcgagaat gggtggcatg cattgaagaa gacaatcgaa tcagtttagc 741901 ttgctttcaa gcagcaggat tcactttaga agacacggaa cctgatgaag atggttttct 741961 tacgctgatt cttcgcaact gatctcatcg aaacacaaaa ggagggcaaa aagccctccc 742021 gttttcatct tcattcagct cggatcactg accttgatca gctgtttccc tttattttct 742081 cccttaaata aaccgagaaa cgcgtcagga atgttttcga agccttctgt gatggtttcc 742141 tcgtaatgga gtttaccagc cttcagccat tctgccagct gttttgctcc ctcagaaaaa 742201 cgatcggagt agtcgcttac gataaagcct tgcatcagcg acttcgtttt aatgagtttt 742261 gattggacac gagggcccat gtcatctgct tcgctttctg cgttatagga agaaatggcg 742321 ccgcacaccg gaatgcgggc aaattcattg agcagattca tcaccgcgtc tgaaatcggt 742381 ccgccgacat tgtcaaaata cacatcgaca ccgtcaggac aagcgttttg aagcgctttt 742441 tggatatcat ccgctgtttt gtaattgatg gcttcgtcaa actgaagctc ctgttttaaa 742501 tagtcgattt tttcatcaga gcccgcgatg ccgacgactc gcgcgccttt gattttggca 742561 atttgcccga ctgttgaacc gacggctccg gcagctcctg agacaaccac ggtttcgcct 742621 tccttcgggc gtccgatgtc cagcaatccg aagtatgctg ttaagccggt cattcccaaa 742681 atgccgagat aggccgaagc gggagcaagg cttgtatcaa tttttcgcaa ggcagactcg 742741 ctcacagcgg aaaattcctg ccagctgaga tttccgatga cgatatcgcc ttttttcaga 742801 tgattcccgt ctgacacaac ttcagcgata acccctccag aaagcgcttt atccaaggcg 742861 aacggctcaa catatgactt cgtatcctgc atacggccgc gcatataagg gtcaaccgat 742921 acataaagcg ttttgacaag cacttcccct tgcttgggtt caggaaccgg aatggtttca 742981 aagcgaaagt cttcatgaac aggaatacct tgtggacgtc ttgctaattg aatttgctgc 743041 tgagatgctg tcattttcat cctcctatca cttggttgac accactgtaa catggacagg 743101 agaggaaata caaaaggtaa gctggcatac aaaaaaggtt atagatgagc ttatgctttc 743161 tacaagctct tttgttttaa aagttctctt tagtcattta tcattattag aaaacagaac 743221 agaaaaagag ctcctgtaca cctagctaag attggctagt gtgtatgtcg attctttttc 743281 atattcttgc aagcatctgc gagggggagc ttagtcgttc acattttgct ttcgcatcaa 743341 tctgcaatag caaagtctat gcgatttttt tacatcagca aagatttgtt caattttttc 743401 cttttatgcc gagtttttct gaaacagata attgatggta ctcaaccatt ttcttttggt 743461 caataaagta atgtttactt attaattaaa cacgcgaaaa agcaaacgaa aacataatta 743521 aattttatat atttattaaa agcttatatg tttatttacc ttttttttga attgtaattg 743581 agaaaatcca tatattgcgg acactaataa aagaatacct gctgaaacat aaactaaacg 743641 aactccaagg aaatctgaaa tagcccctat agccagaatt gaaaacataa aaatgaactg 743701 tactaaagaa gaccttgcag acattatatt aattcgagtt tgctcggttg ttatgttctg 743761 aataagtgtt tcttgtgtaa gatctcttaa tatataagcc ggccccataa agagaaccaa 743821 aattagagct aagtatgaat tacttataaa accatatatt aaagttaaac ttccatatga 743881 gacagcgcca attaacataa aattaattaa cttattttga aatctctccg acagcttata 743941 tattataaat ccccctatca tcgaacctaa ataatatgct ccattaataa atccccacca 744001 tgattctcct ttatgcaaga cttcgttaac gaaagctaaa gagacagatc ctatccaaat 744061 cattcctgcc catgactcaa ttaaatccat aataataatt gttctaagtt tcttttggct 744121 aaataaatac cgccaaccac ttactatact cttattggga gaattttttt cacgtatgac 744181 agaattagcg tggccatgtg gtagacaaaa taaaagagaa agaagagatg taaacaacaa 744241 aaagatagta agtataatgg tatatccctc acctaaaaat gcaattatga gaccacctaa 744301 agaccagcct acaaattgaa aagtttggtc cactgtagat aataatccat ttgcttttac 744361 tcttctatca ggagagatta tttcccctat aattgcactt tttaaaggtg agaaccatcc 744421 attaaaaaag gaaatacagc taataataat aaagactaaa atgagagttt gattagagta 744481 agttcttaat aaagcataga acaaacatat taataacagc atttgtatca attgagaaat 744541 aattattgta agaggcagtt ttaatcgaat tgttattaac ggtaatatag cacttccaaa 744601 aatacgaaaa ataatactta ttaatgtcac catagaggcg atggttgtcg aattggtcat 744661 tttaaacaaa aacgaaatca ctaccatagt atatagagaa aaacctaaat ttgtagtggt 744721 ctggctaaat aaaatagaat aataaccttt actcatatgt atcctccctt ggaataattt 744781 ttctcggtaa agagcttaaa catatttaaa caccttaaaa caacaaaagt aaagaaaaaa 744841 tttccttgta aactatttac ttttattcta tttattgtta ttgtttattt aagttctctg 744901 actattctat caatattcag ggaaccacat atcttattaa aggggggaaa accatgagaa 744961 aattaagaaa aaactggaga aaatcgattg ttagcccggt tctttatact aatgaaaaat 745021 ggtaaacact tagggaatag catttaatgc tattccttat ttcaacaaac aaatcgggag 745081 gttatcgtaa tttgactcta ttaatgcaag atcataaatc aatttacaat aaagatatag 745141 aaatattaat tgaagttgaa gaacttatta cttctgttcc agaaaataaa aaaaatgatt 745201 ttaagagttt aatcgataat agaattatga ctctactaaa taaaattcaa caccctgtag 745261 cagcggaaaa tgtgtttggg atgtgtattg cttatccgaa tacttacata aggtatagat 745321 taattgattt cgttgaaaaa tgggtacctt atttctctgc tgtagaaact ataatcaatc 745381 taacccagga tccggatgat ttagtttctt ttaaagctat ggatgtctgt gcaaatcata 745441 aaattgaaga atctgtagca tatttgtctt cgattattga tgatgtccgg gagagtataa 745501 gctaccctaa aaaacctgtg ggattagggg cccaaaaagt attaagtaca ttattagata 745561 tattcggtgt tgaaaaacat gaagagctag taatgctaaa aaattatttt gatcaaaatg 745621 gtatacttcc taataacttt gactttgaag aaaaaattcc tcaaagtcta atagaggaat 745681 tcgaaaaaac agaagaagat gggatgattt taattccggg tggctttttt gaattcggtt 745741 taaatgaaaa tgaaattcct gacaaaacat ttaattggaa agatgctgtt cctagacaaa 745801 aagtatggtt acctccattt tttatcgata agtatcctgt tacaaataaa gattatgata 745861 tctttaccga gttcatagag gaaaatgggc atatattctg tcatcctaat gaaccgcaga 745921 ataaacaaca tagaagaaat acatattggg atgataggta tttagataat catcccgtta 745981 caggtataga tttttatgat gcatttgctt acgcaagata taaggggaaa gaattgccaa 746041 ccgagtttca atgggaaaaa gctgctcgag gcgaaaaggg taatgtctgg ccttggggag 746101 ataaatttga tcctgcaaag gttcaatatg ctggaagtct ttataatgaa cccattactt 746161 ctttaaagtc ctggagagaa aatttattaa aagctcatgc tgataaagaa ttaaatcatt 746221 taacaagtga tatttttgaa caaaatggtg aaagtcccta tggagtatgc ggtatgatcg 746281 gcggaacatg ggagtggact agaagtgagc ttaaaacaaa gagagctttc caccctattt 746341 ttgagaatgt accatttaat agtgttaact catttgccgt tcttaaagga ggatcattct 746401 tctctcatcc aggcttaatg ttcccttctt ttagagcaaa agatattcct ttctgtcgac 746461 acaatgaaat ggggattaga tgcgtaaaga atattccagt atataaaatt agagaatcaa 746521 ttaatgggcc aattactaat aaagcaattt attaatcatt ctaggttaga gacttgataa 746581 aagtatacta acattgtgta gtaatgttca gcttgtagaa aaaacaatgt tttttctaca 746641 agattttatt ttaaatgctt ttcaaaatta tcagggattg agaatcagaa aaagagccat 746701 taagctcgat cttagctagg tattacgatc ttctgtatat tattgtgaga aatatagaag 746761 attcagttag ttagcatttc gattttaagc tgagcctgca atagcaaagc atctgttttg 746821 attattcttt ttctgataca taagctaatt ttgtcgcttt tcttttttgt cttttcacgc 746881 atttcgagga tgacttacta taattctttc agcttttcta tgtgttaaga ttcgaataga 746941 tgaaataact ttaacaagtt ggtcaataag aacagattta actttatgtt aaaagagtat 747001 ctcgtataga acataagaag aatgacgagt tttttaagat tatcatcaat tatgtgagaa 747061 taaaatatta taagggaaaa tgaaggctgt cacgtttctc gacagcccta gggaattcct 747121 ctccttttca tttcgcccgt aatttcgggc acagtcccgt cggcaggcac attggcttct 747181 ggtcgatcgg gcttctcatg atgcagcatt ccaagccgaa gacttcacgg aaaaatggct 747241 gggtgaacac atcttccggt gttccggcgt tgtatatttt tccgtccagc acactgatca 747301 gatagtcagc atattgagcg gcttggttta aatcatggag caccatgaca acggtgcggc 747361 catggtcgcg gttcagcttt ttcagcagtt caagcacttc aatctgatgt gagatgtcta 747421 aatacgtggt cggctcatca agcaaaagca aatcagtgcc ttgcgcaagt gccatggaaa 747481 tccaggctct ttgtctttgg ccgcctgaga gggcatcaag tgtccgatcc ttcagttcaa 747541 tcatgcccgt tgcttccagc gcccactcta ccatgtcatg atcctcttgg gtatgcttgg 747601 ataacagctt tttgtgagga tgtctgccaa aatagcataa ttcctctacc gtcaatcctt 747661 caggagcctg aggagattgt ggaagaatgg ccagtttttt tgcgacttct tttgatggct 747721 ggcggtggat gtcttttcct tctagtagca ctgtaccgct ttttggggcc atcagcctgg 747781 cgagcgattt gaggattgtt gatttaccgc agccattagc gccgatgagc gcagtgattt 747841 ttccttcttc tatctttaag tcgactccgt caataatcac tgtactgtca tatgaaagag 747901 tgagctggtc tgcagccagt tttcccatgg tatcctctcc ctactgtttc ctcgcttcga 747961 atttcaataa atataagaaa taaggcgcgc cgatcacggc tgtcagtatt ccggcaggta 748021 tttcaaccgg aggcatgatg ccgcgcccta acgtatctgc aattaataat ataatagcac 748081 caatcaatgc cgatgcaggc agtaaatatt tagctttttc tccggtaagc cgtctggcga 748141 tatgcggagc aagcaagccg ataaaaccga ttgagccgac gacggctaca cagcttcccg 748201 ccagcgccac cgcggtgaaa atcaggatga atctcagccg gtttgcgttt tctccgagac 748261 cctgtgcaag ctcatccccg agtgacataa gatccagctt cggtatgagt atgcagacga 748321 tcggaaaaag aatcaaaagc catggcgcaa gcagcttgac ttcttcccag tttcttcccc 748381 agaggcttcc tgtcagccaa atgagtgcag cattcacgtc gcctggaaac ttgaccatca 748441 tatattgcat tccggcgtgg cagaccgcgc ctaaagcaat gcctgataaa gccagtgaag 748501 agggctgaat gctctttttt cgggctatca ttaataatag tacagcaata atggcggctc 748561 cggcaaatgc ggagaacgga agcacgtata ccggcgactc aggaaagatg agaatcacag 748621 ccatcgccgc aagtccggag ccttttgaaa tgccgacaac gtccggggaa gcgagcggat 748681 ttcggatcac accctgtaaa atcgctccgg cagcggcaag tccagcacct gccaaaatcg 748741 ctaatataat gcggggaagg cgatattgct ggatgataaa ttcaaaggaa tgatccagtc 748801 ccagcagatt cgtcactacc gcatcaggtg aaatgtataa tgcaccgatt ccaatgctga 748861 tgacggacag aacgattaaa atcacggcca atatgagtat cgccagtaag gggcgttttt 748921 gttttctggt tgttttcttc atttcaggtt tcgccctttc cttgccaaat ataagaaaaa 748981 cggcgttccg ataatcgcgg tgacaatgcc gaccggtgat tcataaggaa atgcaatcca 749041 tctggccaga acatctgcgt acaccagcaa aatggcaccg aacagtgccg aaaacggaag 749101 cacgtattga taatgttctc cgatcagctt gcggacaata tgcgggacga gcagcccgac 749161 aaagccaatc ggcccggcga cggctacgga agcgccggaa agaattaaaa taatcaaact 749221 gatcagaatc ctgatgccgt tcatattttg tccaagccct tttgctgttt cgtctccgag 749281 accgagaaca gaaacagaac cggaaaatac gagggcaagc ccgatgccaa tgacagaaaa 749341 aggagcgatg gttatgacgt cctgccagtt gctgccgtcg attgcgcctg tcatccagta 749401 cagaacatcc tcacctgact catttaaaat aatgatggcc tgtgtcatag aggagaggaa 749461 caagtgcacg gccattcctg acagcgccag cttgacaggc gtcattccgc cggatgaggc 749521 aatcatatac acaatcgcgc cgcctgctgc cgcacccgca aaagcgaata taacagatga 749581 atagggcgat gccggcagaa tgacgagaga agcaacaaca aaaagcgatg cacccgcatt 749641 cacaccgaaa atttggggtg aagccagagg atttctggtc atagcctgca tcagcgcccc 749701 tgctacagct aggctggcgc cgacaaaaac gccgattaat gtgcggggaa ggcgaagagt 749761 agagatgatg agctgttcct ttgaaccgtc ccatacaaaa agatatttca atgaatctat 749821 gatgctgatg tctgaggctc ctactgaaag attcagccca agcccaaata taaaaataat 749881 cagtgcaatg ataaacatca tcagtcttga tgatgagcgc cgtttggctg aatgatacaa 749941 cagtctcact tccttactgc gtctggttgc aaaaacgaag aagcaaggat tcccctcgct 750001 tctcatttgt cctatttatt atacactttt ttaagcacat ctttggcgct tgtttcacta 750061 gacttgatgc ctctgaatct tgtccaagtg tcacggtccg catcatagac ttgtccattt 750121 ttcaccgctt tgagattttt ccagagcggg ttcgttttcc actcatctac aatggttttg 750181 ccttcgttgg ctgagatgaa caaaatatca ggatcgattt tgctcaattg ctcaaggctg 750241 acctcttgat aggcgttatc tgacttcaca gcgtgtgtaa agcctagcat tttaaagatt 750301 tctccgtcat aggatgatga tgtatgaagc tggaaggaat ccgctcttgc aacgccgaga 750361 acgatgttgc ggttttcatc tttcggaagt tcggctttta gatcgttgat gacttttttg 750421 tgctcggcaa gcttttcttt tccttcatct tctttattta atgctttagc aatggtcgta 750481 aagctgtcga tcgtttcgtc atatgtcgct tcacggcttt ttaattcaat cgtcggggcg 750541 atttttttca gctgtttata aatgttttta tggcgctcag cgtcagcgat gattaaatca 750601 ggcttcaagg aactgatgac ctcaagattg ggttcgctgc gtgtgcctac agatgtgtaa 750661 tcaatggagc tgccgacaag ctttttaatc atatcttttt tgttgtcatc tgcgatgccc 750721 accggcgtaa tgccgagatt gtgaacggca tccaagaatg aaagctcaag cacaaccacc 750781 cgcttaggtg tgccgcttac tgtcgttttt ccttcttcgt catggatcac tctggaatcc 750841 ttagactcgc ttttgccgct tccgttgtta ttctggcttg atgaacagcc ggatacaatg 750901 aggcaggcga gcaataaaac actcatgatg gcaatcaact tgttagaata ggtgcgcatg 750961 tcattcttcc ttttttcaga tttagtaatg agaatcatta tcacatgtaa cactataata 751021 gcatggctta tcatgtcaat atttttttag taaagaaagc tgcgttttta ctgctttctc 751081 atgaaagcat catcagacac aaataagtgg tatgcagcgt taccgtgtct tcgagacaaa 751141 aacgcatggg cgttggcttt agaggtttcg aacatatcag cagtgacata aggaaggaga 751201 gtgctgagat aaccggacaa tttcttttct atttcatctg ttagtgcaaa ttcaatgtcg 751261 ccgatattca tgataatcga gaaaacaaag tcgatatcga tatgaaaatg ttcctcggca 751321 aaaaccgcaa gctcgtgaat tcctggtgaa catccggcac gcttatggaa aatctgtttg 751381 actaaatcac tcacaatcca agcattgtat tgctgttctg gtgaaaagta ttgcattaga 751441 catacctcct gctcgtacgg ataaaggcag cgtttcatgg tcgtgtgctc cgtgcagcgg 751501 cttctcctta attttgattt ttctgaaaat aggtcccgtt cctatcactt taccatggac 751561 ggaaaacaaa tagctactac cattcctcct gtttttctct tcaatgttct ggaatctgtt 751621 tcaggtacag acgatcgggt atgaaagaaa tatagaaaac atgaaggagg aatatcgaca 751681 tgaaaccagt tgtaaaagag tatacaaatg acgaacagct catgaaagat gtagaggaat 751741 tgcagaaaat gggtgttgcg aaagaggatg tatacgtctt agctcacgac gatgacagaa 751801 cggaacgcct ggctgacaac acgaacgcca acacgatcgg agccaaagaa acaggtttca 751861 agcacgcggt gggaaatatc ttcaataaaa aaggagacga gctccgcaat aaaattcacg 751921 aaatcggttt ttctgaagat gaagccgctc aatttgaaaa acgcttagat gaaggaaaag 751981 tgcttctctt tgtgacagat aacgaaaaag tgaaagcttg ggcataaagc aaggaaaaaa 752041 ccaaaaggcc aatgtcggcc ttttggtttt tttgcggtct ttgcggtggg attttgcaga 752101 atgccgcaat aggatagcgg aacattttcg gttctgaatg tccctcaatt tgctattata 752161 tttttgtgat aaattggaat aaaatctcac aaaatagaaa atgggggtac atagtggatg 752221 aaaaaagtga tgttagctac ggctttgttt ttaggattga ctccagctgg cgcgaacgca 752281 gctgatttag gccaccagac gttgggatcc aatgatggct ggggcgcgta ctcgaccggc 752341 acgacaggcg gatcaaaagc atcctcctca aatgtgtata ccgtcagcaa cagaaaccag 752401 cttgtctcgg cattagggaa ggaaacgaac acaacgccaa aaatcattta tatcaaggga 752461 acgattgaca tgaacgtgga tgacaatctg aagccgcttg gcctaaatga ctataaagat 752521 ccggagtatg atttggacaa atatttgaaa gcctatgatc ctagcacatg gggcaaaaaa 752581 gagccgtcgg gaacacaaga agaagcgaga gcacgctctc agaaaaacca aaaagcacgg 752641 gtcatggtgg atatccctgc aaacacgacg atcgtcggtt cagggactaa cgctaaagtc 752701 gtgggaggaa acttccaaat caagagtgat aacgtcatta ttcgcaacat tgaattccag 752761 gatgcctatg actattttcc gcaatgggat ccgactgacg gaagctcagg gaactggaac 752821 tcacaatacg acaacatcac gataaacggc ggcacacaca tctggattga tcactgtaca 752881 tttaatgacg gttcgcgtcc ggacagcaca tcaccgaaat attatggaag aaaatatcag 752941 caccatgacg gccaaacgga tgcttccaac ggtgctaact atatcacgat gtcctacaac 753001 tattatcacg atcatgataa aagctccatt ttcggatcaa gtgacagcaa aacctccgat 753061 gacggcaaat taaaaattac gctgcatcat aaccgctata aaaatattgt ccagcgcgcg 753121 ccgagagtcc gcttcgggca agtgcacgta tacaacaact attatgaagg aagcacaagc 753181 tcttcaagtt atccttttag ctatgcatgg ggaatcggaa agtcatctaa aatctatgcc 753241 caaaacaatg tcattgacgt accgggactg tcagctgcta aaacgatcag cgtattcagc 753301 gggggaacgg ctttatatga ctccggcacg ttgctgaacg gcacacagat caacgcatcg 753361 gctgcaaacg ggctgagctc ttctgtcggc tggacgccgt ctctgcatgg atcgattgat 753421 gcttctgcta atgtgaaatc aaatgttata aatcaagcgg gtgcgggtaa attaaattaa 753481 gaaagtgaaa aacacaaagg gtgctaacct ttgtgttttt taattaatta aaatgtttat 753541 taacttagtt aaggagtaga atggaaaagg ggatcggaaa acaagtatat aggaggagac 753601 ctatttatgg cttcagaaaa agacgcagga aaacagtcag cagtaaagct tgttccattg 753661 cttattactg tcgctgtggg actaatcatc tggtttattc ccgctccgtc cggacttgaa 753721 cctaaagctt ggcatttgtt tgcgattttt gtcgcaacaa ttatcggctt tatctccaag 753781 cccttgccaa tgggtgcaat tgcaattttt gcattggcgg ttactgcact aactggaaca 753841 ctatcaattg aggatacatt aagcggattc gggaataaga ccatttggct tatcgttatc 753901 gcattcttta tttcccgggg atttatcaaa accggtctcg gtgcgagaat ttcgtatgta 753961 ttcgttcaga aattcggaaa aaaaaccctt ggactttctt attcactgct attcagtgat 754021 ttaatacttt cacctgctat tccaagtaat acggcgcgtg caggaggcat tatatttcct 754081 attatcagat cattatccga aacattcgga tcaagcccgg caaatggaac agagagaaaa 754141 atcggtgcat tcttattaaa aaccggtttt caggggaatc tgatcacatc tgctatgttc 754201 ctgacagcga tggcggcgaa cccgctgatt gccaagctgg cccatgatgt cgcaggggtg 754261 gacttaacat ggacaagctg ggcaattgcc gcgattgtac cgggacttgt aagcttaatc 754321 atcacgccgc ttgtgattta caaactgtat ccgccggaaa tcaaagaaac accggatgcg 754381 gcgaaaatcg caacagaaaa actgaaagaa atgggaccgt tcaaaaaatc ggagctttcc 754441 atggttatcg tgtttctttt ggtgcttgtg ctgtggattt ttggcggcag cttcaacatc 754501 gacgctacca caaccgcatt gatcggtttg gccgttctct tattatcaca agttctgact 754561 tgggatgata tcaagaaaga acagggcgct tgggatacgc tcacttggtt tgcggcgctt 754621 gtcatgctcg ccaacttctt gaatgaatta ggcatggtgt cttggttcag taatgccatg 754681 aaatcatccg tatcagggtt ctcttggatt gtggcattca tcattttaat tgttgtgtat 754741 tattactctc actatttctt tgcaagtgcg acagcccaca tcagtgcgat gtattcagca 754801 tttttggctg tcgtcgtggc agcgggcgca ccgccgcttt tagcagcgct gagcctcgcg 754861 ttcatcagca acctgttcgg gtcaacgact cactacggtt ctggagcggc tccggtcttc 754921 ttcggagcag gctacatccc gcaaggcaaa tggtggtcca tcggatttat cctgtcgatt 754981 gttcatatca tcgtatggct tgtgatcggc ggattatggt ggaaagtact aggaatatgg 755041 tagaaagaaa aaggcagacg cggtctgcct ttttttattt tcactccttc gtaagaaaat 755101 ggattttgaa aaatgagaaa attccctgtg aaaaatggta tgatctaggt agaaaggacg 755161 gctggtgctg tggtgaaaaa gcggttccat ttttccctgc aaacaaaaat aatggggctg 755221 attgcggctc tgctggtctt tgtcattggt gtgctgacca ttacgttagc cgttcagcat 755281 acacagggag aacggagaca ggcagagcag ctggcggttc aaacggcgag aaccatttcc 755341 tatatgccgc cggttaaaga gctcattgag agaaaagacg gacatgcggc tcagacgcaa 755401 gaggtcattg aacaaatgaa agaacagact ggtgcgtttg ccatttatgt tttgaacgaa 755461 aaaggagaca ttcgcagcgc ctctggaaaa agcggattaa agaaactgga gcgcagcaga 755521 gaaattttgt ttggcggttc gcatgtttct gaaacaaaag cggatggacg aagagtgatc 755581 agagggagcg cgccgattat aaaagaacag aagggataca gccaagtgat cggcagcgtg 755641 tctgttgatt ttctgcaaac ggagacagag caaagcatca aaaagcattt gagaaatttg 755701 agtgtgattg ctgtgcttgt actgctgctc ggatttattg gcgccgccgt gctggcgaaa 755761 agcatcagaa aggatacgct cgggcttgaa ccgcatgaga tcgcggctct atatcgtgag 755821 aggaacgcaa tgcttttcgc gattcgagaa gggattattg ccaccaatcg tgaaggcgtc 755881 gtcaccatga tgaacgtatc ggcggccgag atgctgaagc tgcccgagcc tgtgatccat 755941 cttcctatag atgacgtcat gccgggagca gggctgatgt ctgtgcttga aaaaggagaa 756001 atgctgccga accaggaagt aagcgtcaac gatcaagtgt ttattatcaa tacgaaagtg 756061 atgaatcaag gcgggcaggc gtatgggatt gtcgtcagct tcagggagaa aacagagctg 756121 aagaagctga tcgacacatt gacagaggtt cgcaaatatt cagaggatct cagggcgcag 756181 actcatgaat tttcaaataa gctttatgcg attttagggc tgcttgagct tggggagtat 756241 gatgaagcca ttgatctgat taaagaggaa tatgcgatac aaaatgaaca gcatgatctt 756301 ttattccata acatccattc gcagcaggtg caggccattt tgttagggaa aataagcaag 756361 gcatcggaaa agaaggtcaa gctggtgatt gatgagaaca gctcactcgc gcctcttcct 756421 gcgcatatcg gcttgtccca tcttattacg attattggca atttaattga taacgctttc 756481 gaagctgtag cggagcaaag cgtgaaggaa gttttgtttt ttatcacgga tatgggccat 756541 gacattgtca ttgaagtatc agacacaggg cccggtgtgc cgccagagaa aatagaagct 756601 gtgtttgaga gaggctattc ttcaaagggg atgaggagag gctacggtct ggccaatgtg 756661 aaagactcag tgcgtgaact gggcggctgg atcgaactgg cgaatcaaaa aactggcggg 756721 gcggtattca ctgtatttat accgaaggag aaacaaaggg ggaatccatt tgattcacat 756781 cgcgattgcg gaggatgatt ttcgagttgc gcaaatccat gagagattga ttaaacagct 756841 tgatggattc aagattatcg gcaaggcggc taacgcaaaa gagacattgg cgcttttgaa 756901 ggaacacaag gctgatttgc ttctgctgga tatttatatg ccggacgagc ttgggaccgc 756961 gttgattcct gatatacgaa gccgatttcc tgaagtggac attatgatta tcacagcggc 757021 aacagaaacc cgtcatttgc aggaagcgct aagggcggga attgcccact atttgatcaa 757081 acccgtaaca gctgacaagt tcaggcaggt gctgcttcag tataaagaaa aaaggaagct 757141 gctcatgtct cagccggagg tcagccaatc catgatcgac catatttttg ggaacggtgt 757201 gaagacagct ttgccggcag aggatttgcc gactggcatt aattcgatta cactgcgaaa 757261 aattaaggaa gcgcttcaga ctgcgtcaga aggattgaca gcggaggaac ttggggaaaa 757321 aatgggggcg tcacgaacaa ctgcccgccg ttatgccgag taccttgtgt caaaggaaga 757381 agcaagagcc gagcttgaat acgggattat cggcaggccg gagagaaaat attatttggc 757441 ggcggattag atatgaaaaa atctataatc ctattgaata ttctattgat ctttatgcag 757501 ggtgatatca ggcaggcggc tgcgccgcgc ctgccggacg ggccgataga aattgtcgtc 757561 cctgccgaac cttctggcgg ctgggatgtc acagcgcagg cgatccaatc agttttgagg 757621 cagaagcaga tcgtgaagga tgatgttcat atcgtctata aatccggcgg cgggggagag 757681 aaaggctgga aatatgtcaa caaaagcagc aaacaaacca tcagcatgac gtccagccta 757741 atattgagca atgatcttct cgggcaaagc aaattaaaaa tgtccgattt tacgccgctc 757801 gccattctct ccaaggaatg gcagacggtt gcattgccaa aaggatcagc gttaacaaat 757861 ggcaaggatg tgctgaatga gatcaacatg catcccggca aggtgagaat cggctttgcc 757921 ccggggtttg gcaatgatga tcagctctcg ttcgtcagag cggcagatat gtacggcatt 757981 gacccgtttg acattcaatt ctcacagtat gacagcagcg aacagctcat tcaggcgctg 758041 atcagacatg agatagaagc ggcttccatg acactttctg aagcgaaacc atatgaacga 758101 aacggcgata tcacgttagc cgctgtaacg tctgataaaa gacttcccgg ttttccaaat 758161 gtaccgacgt ggaaggagca gggaatcccg tttgtttttt ctcattggag agggattttg 758221 ggcccgaaaa atatgtctga ggaagagatt tcttactggg atcaagcgct aaagaaggtc 758281 acctcctcac ctgaatggaa gcggaaaata aacgaacagg actgggaaag cttttattta 758341 aacagcaggg aaacgaaacg gtttttagaa gagcaatctg ctttttatca aagcatcatg 758401 acaggaaatt aaaatcccga catcccggga tttttttcat gccgaaaatt gatcaaaaag 758461 aacaaaacgg ttttaaaaaa ttaaaaatac aaaaaaacca aattatttac ttgcggttgg 758521 ttttcccata cgatggcaaa aaggcaagac aaaaagggga gtaagggaga aaaaaatgta 758581 agcggattca tttaaggggg aatggatgtg ttagcaatct taggctttct catgatgctt 758641 gtgtttatgg cattgatcat gacaaaacgg ctttctgttt taacagcatt agttttgacg 758701 ccgattgtgt ttgcgcttat cgccggattt ggatttactg aagttgggga catgatgatt 758761 tcggggattc agcaagtcgc gccgactgcg gtcatgatta tgtttgcgat cttatatttt 758821 ggaattatga ttgatacagg cctgtttgat ccaatggttg gcaaaatttt aagcatggtc 758881 aaaggagacc ctttaaaaat tgttgtcggg acagcggttc ttacaatgct cgtcgccttg 758941 gacggagatg gctcgacaac gtacatgatt acgacaagcg ccatgcttcc gctctatttg 759001 ctgctaggca tccggccaat tatcttggca ggaatcgcgg gagtcggcat gggaatcatg 759061 aacacgattc catggggagg tgcgacgccg agggcggcga gtgcgctggg ggttgatcca 759121 gctgagctta cagggccgat gattcctgtc attgcaagcg ggatgctttg tatggtggca 759181 gttgcgtatg tgcttggaaa agcggaacga aagcgccttg gtgtgattga actgaaacag 759241 ccagccaatg ccaatgaacc ggctgctgcg gttgaagatg agtggaagcg gccgaagctt 759301 tggtggttca atttattgtt aacgctttct ttaataggat gtttagtatc gggtaaagtc 759361 agtttaaccg tactgtttgt cattgcgttt tgtattgcgc tgattgtgaa ttatcccaat 759421 ctcgagcatc agagacagcg catcgcggcg cattccagca acgtgctggc tatcggttca 759481 atgatttttg ctgcgggggt gttcacgggg attttgacag gcacgaaaat ggttgatgaa 759541 atggcgatct cgctcgtgtc catgataccg gaacaaatgg gcggattgat cccggcgatt 759601 gttgccttaa caagcggcat tttcacattt ttgatgccga atgacgcgta tttctacggg 759661 gtgctgccga ttttatcaga aacagctgtc gcatacggtg tggataaagt ggaaattgcc 759721 agagcctcta ttatcggcca gccgattcat atgctgagtc cgcttgtgcc atccactcat 759781 ttgcttgtcg gactcgtcgg agtttctatt gatgaccatc aaaaattcgc attgaaatgg 759841 gcggttctcg cagtgatcgt catgacggct atcgctctat tgatcggtgc gatctctatt 759901 tccgtatgat aattcaggcg taatgacaca cactaacggc atacaacatt ccggaggtgt 759961 cattatgagt gatccttata tgccgctgac ttcagtcaga agcggagcgg ggttcgaagc 760021 ggcaaaaggg gtgcacggcc tgactgtgca aattgcgaat gtctatttta ttcagctgcc 760081 ttctgaacct cactcatttg ttttaattga tgccggcatg ccccaatcag ccggcgtgat 760141 tgtcaatgaa gccaaacaaa gattcggtga agggtttcag ctgaaggcga ttatcctcac 760201 acacgggcac tttgaccata ttggggcaat cgaagagatc cttgagcatt gggatgtgcc 760261 tgtttatatc cattctcggg aaatgcctta tgtaacaggt aaagaggatt atcctccggc 760321 tcgtcctgac agcaagagcg ggctggtcgc taagctgtcg ccgctgtttc cgcggcactc 760381 tatcgatatt tcctcacatg tccaggcact gccggaagac ggttcagttc cttttcttga 760441 cgagtggatg tggatcgcga caccaggaca cacgccgggc catatttcgt tattccgcga 760501 tgacggccgc gtgcttgtgg caggtgatgc tgttattaca gtggaacagg agaaaatggc 760561 tgacgtcttg atacaaaaac aggagcttca cgggccgccg gcttatttca cgcctgacac 760621 agagacggcc gctgagtcca ttctaaagct ggccggtctt gaaccggaag cgttattgac 760681 cgggcacggc ataccgatga ccggcaaaaa ctttcgaagt gacttaactg aattggcaaa 760741 tcggttatcg tctatttgac acccgcacca cgcgggtgtt ttttattgtt ttccaggaag 760801 ttgcagaaaa atcatttgtc ttgccgctta aaaacgatac aatgaaaagc atgaagtgat 760861 gtgaagggga gagtttgttg gaagaaaaag aaatactctg gaacgaagcg aaagcgttta 760921 ttgccgcatg ctatcaggaa ttgggaaagg aggaggaagt gaaagaccgt ctcgcggaca 760981 ttaaaagtga aattgacctg accggaagct atgtacatac gaaggaagag ctggagcacg 761041 gagcgaaaat ggcttggaga aacagcaacc gctgcatcgg cagattgttc tggaattcgc 761101 tgaatgttat cgacagacga gacgtccgga cgaaggagga agtgcgtgat gccctctttc 761161 accatattga aaccgccacc aataacggga aaatcagacc gaccattacg attttccctc 761221 cggaagagaa gggtgaaaag caagtcgaga tctggaatca tcagctgatc cggtacgctg 761281 gatatgagtc agacggagaa agaatcggcg acccggcttc ctgttccctg acagcagcct 761341 gcgaagagct cggctggcgc ggagagcgaa cggattttga cctgctgccg ctcatttttc 761401 gcatgaaagg ggacgagcag cctgtctggt atgagctgcc gcgttcactt gtgattgagg 761461 ttccaatcac acatccggac atcgaggcgt tttctgattt ggagctgaag tggtacggcg 761521 tgcctattat ttctgatatg aagcttgagg tcgggggcat tcattataat gccgcgccat 761581 ttaacggctg gtatatgggc acggagatcg gagcgagaaa cctcgcagat gaaaagcggt 761641 acgacaagct caaaaaagta gcgtccgtga tcggcatcgc cgctgattac aatacggatt 761701 tatggaagga tcaagcgcta gttgaattga ataaagctgt gctgcactcg tataaaaagc 761761 agggtgtcag catcgttgac catcatacag cggcaagcca gtttaaacgg tttgaagaac 761821 aggaggaaga agcgggcaga aagctgacgg gggactggac gtggctgatt ccgccaattt 761881 cacccgctgc cactcatatc ttccaccgct cctatgataa ctcaatcgtt aagccgaact 761941 atttttatca agataagcct tatgagtaaa caatagaaaa tcgatgatgg ccttcaaggc 762001 tgcgggattc agtcacagag atgtcggtaa cctttgagaa agggcttccg ttctttacag 762061 cctcaacaaa cgattgcagg gcgttttccg gaccctctgc caaaatctcg acacgcccgt 762121 catcacggtt tttgacccag ccggccagtt ttcgcttatc agcttccatt tgaacaaaat 762181 agcgaaagcc cacaccttga acccggccgt ctacaatgat tcggtattga agcatgtaaa 762241 aaccaccttt tctttttatg ataatcaatc attttacaac ctgtaaaggg gatgtgtttg 762301 tatgaaacaa gagcgctatt cagttctttc tcttaatctg ggaaaaccgc agacgcttga 762361 atatgacgga aagaaaatcg aaaccggcat catgaagcgg ccggctaaat cagccgtcat 762421 gctgtatcgg gagaattttg aaggagacgg acaggcggac ctcgtcaacc acggcggacc 762481 tgataaggct gtctgtgtct acccggcgga gcattatccg ttttgggaag agttcctctc 762541 aagaccgctg tcaaatgccg catttggaga aaatctgacg gtcgcgggcc tgactgagga 762601 gaatgtttgc atcggggatg tgttcagact tgatgaagct gttgttcagg tcagccagcc 762661 gcgccagccg tgtgtaaagc tggcgaaaaa gtttggtgta aaagaaatgg tgctgaaggt 762721 ccagcaaacc ggctatacag ggttttattt tcgcgtgctg gaggagggca gggtgtctcc 762781 cggcgcgaac cttgaattgc tgtccagagg agagaaaggc atatccgtcc agttcgcgaa 762841 ccgcatcaac taccatgatg caaaaaatct caccgccatt gaacggattt taagtgaggc 762901 tgcactatcg gaaagctgga gagcgtcctt tatgaaaaaa aaggacaggc tgctgccggt 762961 tgaatagaaa aaagccgcgc atatcaacgt gcgcggcttt gccatattta agattgtttt 763021 ttctttgatt caagcaggtt ggcaagaaaa taggttttat agctttgaag ctttcttcct 763081 tcatggtgcg tgatcccctg cttttttagt tctgccacat accagccttt actgccgtaa 763141 tgcatgtcag aaaactcctt tccctatctg atttcgaaac gattggcatt gtaacatcta 763201 taaaaagatg ctgaaaagag atgcggggaa aactgagcct ttcgcactag atgtacgaat 763261 gttcttctga atgtatatgc ggagcaaaag ccgaatatga tttaatggcc ggttagtttg 763321 atcatgacaa cgccaaatgt cataatggcg aaaacaatgc cgatatatgt gagcatcccg 763381 ttttttttct taacgccgta aacggtcata atgatgcctt caatgaaaaa aatgatgccg 763441 aaaataataa accacatgca gataaaggct cctttcacag acataatagt agtgtagcat 763501 atctgaaaga gccgggctgt gacaatatca agaaagccgg gcgcatatcg cccggctcat 763561 gttttattgt ttatcaacca atttgaccag aagctgtgcc aaatgttctt tctcatcttc 763621 gtctgcaacg ctccaaagct cttgcagcag catttcttca ccgttttgcg gctcttcatg 763681 ctttgcgagg tagtctccca ggatcgcagc gctttttaca agcttgccgt catccaatcc 763741 cagctttttg cctcggttga cttgtttttt caggtagcct ttaaattcct caaagtcttt 763801 taaaatgtct tcttttattg tgccatgcat cgcgttcatt tcgttttcaa tttggatttt 763861 ttcttgatct ctgttcattg caagacctcc tcgtacagaa taatgatgct ttacctgcaa 763921 ttggaggagg ttaaacctgc cggaagcccg gaatgtgttt tacagtttcg tcaggataat 763981 cggttcatct tttgtgatga cgatcgtgtg ttcaacttgg gcaaccatgc ttttatccgg 764041 cgtcttgaac gtccagccgt ctccagcttc aacaatcgtt tctgctttcg ttgaaataaa 764101 cggttcaagc gcgatgactg tgccattttt gaacagcgca ttatcaaacg gatcataata 764161 gttcatgatg tggttcggcg cttcatgcag gcttcggccg attccgtggc cggtcagggt 764221 tttgatgacg gtaaagcctt gagagcgtgc ttcatgataa acggctcttc cgatctggtt 764281 ttggcgcttg cccgcttttg cctgctgaag ccccttttga aaagcgtttt ccgcgcattg 764341 gcaaagctta tgaaggcgtt cttctccttc accgagcaca aatgagatgc ctgtgtcgga 764401 atagaagccg ccaaattcag cggagatgtc gatgttgaca aggtcccctg cttttaaaat 764461 tttggatgtg cttggtatgc cgtgagccac ttcatcattt acgctgatac atgtcacacc 764521 tggaaaatcg tattccttct caggagctga aacggcgccg tgctcatcaa gcacagcttt 764581 tccgataagg tcaaggtctt ttgtgctcat gccgggctct gccttccgct tcatttcttc 764641 acgcgcaagc gcgacgattc ttccgatttt tttcaggcct tctaattctt gatcgtttgt 764701 tacaatcatc tgtcattccc gctttctttt taaataatct agattaagct taccacaact 764761 gtcttaaaaa taggaaacac acggacctgg gaaaaaagaa atacccccgg gaaaattggt 764821 atagatcact agatatctta tatggtatat ttgaaaaaaa agggtatgag ggggatgggt 764881 atgctttcat ttttacaaaa actcgggaag tcatttatgc tcccgattgc ggttctgcct 764941 gcggttggaa ttatccttgc gcttggcaga gaggatgtat ttaatatccc gtttgtctat 765001 caggcgggga cggcggtttt tgatcatctg ccgcttattt ttgcgatcgg tattgccatc 765061 ggcatttcaa aagacagcaa tggggcagcg ggtttatcag gggcgatatc gtatctgatg 765121 cttgacgcgg caacaaagac aattgataaa acaaataaca tggcggtgtt tgggggaatt 765181 attgccggtt taattgccgg ttacacctat aaccgcttca aggataccaa gctgcctgaa 765241 tatctcgggt tcttcagtgg cagacggctt gtgccgattt taacagccat tattacgatc 765301 attttagcgg gcatattcgg agtggtctgg ccgccgattc aatcgtgtat caactcgttt 765361 ggagagtgga tgctcgggct cggcggcatc ggggcaggca tattcggcct attcaacagg 765421 ctgttaattc cgcttggcct tcaccatgtg ctgaacaata ttttctggtt ccaattcgga 765481 gaatataacg gagtgacagg ggatttggcg cgctttttcg cgaaagatcc gactgcgggc 765541 acatatatga ccggattttt cccaatcatg atgttcggtc ttccggcggc gtgtctggct 765601 atggttgtga ctgcgaagcc gtctaaacgg aaagcgacgg ctggaatgat gattggattt 765661 gctttaacgg cgtttatcac agggattacg gagccgattg agtttgcatt tatgttttta 765721 tctccgcttt tatacgctgt tcacgcggtc ttaaccgggt tatctttatt tatcgtcaac 765781 tggctcggca tccgctcagg cttctctttt tcagccggag ctatcgatta tgtgctcagc 765841 tatggaatcg cggaaaaacc gctgcttctg cttttggtag gtatatgcta tgcggcagta 765901 tactttatcg tgttttatgt actgattaag gctttgaatt taaaaacgcc tggacgggaa 765961 gacgatgatg tggatgaagt gctggatgaa aatactgttc aggatgtaaa tgaaaacatc 766021 atgctgaaag ggctcggcgg aaaagaaaac cttcaaacca ttgatcattg cgccacaagg 766081 ctgcgactga ctgtgaagga taccgctttg gtggatgaag cactgctaaa gaaagcaggc 766141 gcaaaagggg ttgtcaaatc gggcgggcaa tcggttcaag tcattattgg cccgaatgtg 766201 gaatttgcag ctgaggaatt gagggctgct gtcaaataaa aaagcggaga gggcaacctc 766261 tccgcttttt cttatttatc ttcgttatcc tttgacgttt cggaagaatc ttcgtcatgt 766321 tttgtgtaat cataatcaga aggattcacc ttcttaaaac ctttcggctc gtagaaccgc 766381 agcaggtctc cgtttatgat tttatcggac atttcaagtt ccttcttgac gagtgagtct 766441 tctgacttgt cgacttcgga ttcatcgagt tcttttccgg ttttcgtgtc gtaatactta 766501 ccggatattt tcgtgtactt cggtgaaata aagtctccgt ttcggaacgg aatcacttca 766561 cggtgttctt tcgataaaat atcagaaccg gacatcagat agtccttcgt atccactccg 766621 agcagatgca gaatggtagg agccacatca acgtctccgg catatttatg aactttctcg 766681 cccttcacgc cggcagcgtg gataaagagc ggcacccgtt gaagctgggc gttgtcgtaa 766741 tcagtgattt catccttgcc aagcactttc gccatcgctt tattgtggtt ttcagagatg 766801 ccgtagtggt ctccgtacat cacaataatc gatttatcat ataacccgtc ttttttcaga 766861 tcattgaaga attgttcaat ggactgatca aggtaatggg ctgactggaa atagttatcg 766921 acgacagagt caccaaagtc tccagccggg aagtctgtat ccccctcatc cattccgaat 766981 gggaagtggt tggaaagggt aatgaacttc gtatagaacg gctgcggcag gctttccagc 767041 agcggcattg attctttgaa gaacggtttg tctttcatgc cgtagttttt cgtgttttct 767101 tcgttcatgt catagtaagc agaatcaaag aatttatcaa tgccttccgc cttgtacatt 767161 tcgttacggt tccagaacgt ctgcgtgttc ccgtggaaag tagcagatgt gtaattctta 767221 gacttcagaa tcgccggaac ggattgcagc gtgttttgcg ctttgtttac gaaaactgaa 767281 ccttgagcca gcgggtacag agagttttcc atcataaatt cagcatcaga tgttttacct 767341 tgtcccgttt ggtggaaaaa gttatcaaag tagaacgttt cgttatcatg tgccagttta 767401 tttaagaatg gtgtcacttc tttgccgtca attttatagt cgatgataaa tgactgcaaa 767461 gattcaagtg aaacgtaaat gacgtttttt ccttccgctt tgccgaaata cacgttattc 767521 ggcacatcgt aattggcttt catgtagttt tctacttccg ttacgtcgct ggaatcggca 767581 agcgcgcgct ggctgttgga cttgatattc tgtacagcgt cataaatcgt gaaattgtat 767641 gttcccaagt atttcacaag atagttccgg tcgaatgatc ttgtcagcaa ttcaggacgg 767701 tctgattccg caactgccag gttgatcaag aacacaagaa ttgaagacgc aaaaataatt 767761 cggaacgatt ttttgcttga cgtttcggca ggcttgttta ctttgatcgc caagatgatc 767821 aggatgatcg tatcgataaa gtaaaaggcg tcagtcggtc tcatcagcga aaatgcgctg 767881 tcaccgagtt ggccgccgtt tgttttagcc tgcataatga ccggaattgt aataaaatca 767941 ttgaaaaatc tgtagtacac aatgttggcg tacagtaaaa aagacattaa aaaatgaatc 768001 actataatgg ctgtctgctg taattttttc ttgaacaaga gtccaaagcc aagaaagaac 768061 aagcttgagc taagaggatt cacaaaaagc aatatttttt gtatcgtgtt gtctattcct 768121 aagttgaaat tcaggacata accgacatac gttttgatcc ataacaggac gaccgcaatt 768181 aagaagaagg ccagtcctct ttcttttata aatgttttca ttgttacact ccttttttcc 768241 gatccagttc gagcgaaacg atagaaaaaa cgaacgtatc caatataaca cgaatcagca 768301 gattagaaaa gtgaaaatcg tatgagggag aaagtggcga aaaacgccgt cgaatcaacg 768361 tttcgctttg atattaccaa atgtaaaaca aggtatcttt ctagaaataa aggaataaaa 768421 tggtacattg agaattgtat gataaaatat aaggtataga taaaaagagg tgaaatgatg 768481 gatttttccc atattgtgtc tgaagataaa attaagcgcg ccatcaaaga cggggacttt 768541 caaaacctcc cgggaatggg gaagccgctg ccgaaggatg acgcggcaca cttgccggaa 768601 tcgctgcgca tgggctatcg tattttgaaa aacgcgggaa tggcagagga cgagggcgcg 768661 ctcaaaaaag agcttatgac catcgaccat ttaatcgaaa agtgctatga cgaaaaagaa 768721 cgcgagcaat taatcagaaa aaaatctgaa aagcaattgc tgcttgataa gcttgtcgac 768781 aaaaaaggca tgttttcaaa gccagcatcc gctttttata agaataaagt atatgaccgg 768841 cttggacgaa acagaccttc ttccagctga tttgtcttgt ctgcaggatg gcgattgata 768901 aaagccatcc tttttatgtt ccaagttcta tgtcaaaagg tttatgtttt tccatctatg 768961 ggaaatgatt cataaacgaa aaaagggtga tgggatggaa cgactattag tatggataga 769021 gcatatatct gattggctgt ggggtccgcc gctaatcatc ctgctgacgg ggacgggctt 769081 gtatttcact attttgctga aaggttttca atttcgctat cctttataca ttttcaaaca 769141 gacaatcggc agtgtaggaa aaaagccgaa gggagaaggc acagtcacac cgcttcaggc 769201 attgacctca gccctcagtt caacgatcgg tgcagcgaac attgtcggtg tgcccgccgc 769261 tattatgttt gggggaccag gagcggtttt ttggatgtgg cttattgcct tatttgccat 769321 ggcgattaag ttttctgaaa gtgttcttgc tgttcattac agagaaaaaa atgagcaggg 769381 tgaatacgtc gggggaccga tgtattacat aacaaaaggg ctgcgcatga aatggctcgg 769441 cgtattcttc tctgttgcgc tgattgtgga gctgattccc agcattatgg ttcagggaaa 769501 ttcggtttca gtctcgcttg ccgagacgtt ttctttcaat aaaatatacg caggaatcgg 769561 aattgcattt ttgattgggt tagtggtgat aggaggggta aagcggatcg gaaaagtaac 769621 agagtttgtc gtgcctctta tggcaggggc atacgcaggt gccggtctcc tgattgttct 769681 catgaatcta tcatcagtgc cggcgttttt ctctctcgtt ttttcaaatg cgtttacctc 769741 ttcttcagca gttggagggt tcgcaggtgc tgcgttggcg gaaaccgttc gctggggatt 769801 tgcccgcggg ctgtattcta atgaagccgg gatgggaaca gccccgattg cacatgcggc 769861 agcaatgact gatcatcctg tgcggcaagg gttttggtct gtgatcggca ttgtcattga 769921 caccttaatc atctgtacga ctaccgcttt tatcgtcctt gcatccggtg tatggacagg 769981 gaagaacgcc tcaaatgacc cggcagcact gacaacggcc gcatttcagc actatttcgg 770041 ttctggagga ggatacttcg tttcggtttc cctggtcttc tttgtcgtat caaccattat 770101 ggttgtcatt ttttacggcg taaagcaagc tgaatttctg ttcgggcggc tggcaggaca 770161 tgtgattaaa ttcgtttatt tagcggctat tatcataggt gccgcaggcg gagcaaaagc 770221 catttggggc gtattggact tagcattggt ttttattgtt gtcccgaatg tgattgcgct 770281 cttgttattg agcagaaagg taaaagcgct gtacaccgaa ttctttacat ctgaacagta 770341 ctacctgaaa gatataagaa aaacgaaaca aaagcctgtt tatccaacaa aagaagctaa 770401 aaattcctag tgttttgctt ttgcgccgaa caatgctttg ctttttatga tcaaataaat 770461 gagtaaaggc agcaaaagag aaatcactac attaatgatt ggtttgattc tgttaaagtc 770521 gattagctga tttgtattta aaaaaaacca aaagccgcat acgactgaga acatgccggt 770581 tggtgtatac atggctttcg ggtcgatttt tgagtgtaaa aacgaaaggc cgtataccac 770641 gatatatagg gaacctgcta tcttcaccat aatgaccgga atccaaaaag ccgcgatgat 770701 caggtctgag cgatccagaa aatccgtaat gcggatctgc ctgatgacca tataagcagg 770761 atcaaagaaa gtagatgtca ggttgggacc aaagacagaa attgaagaaa ataacatcac 770821 ggccagcaat aaagcgccca gcagtatcgc gaaaatggtg tattttagcg ggacgctccg 770881 gtttgagaag agaagcggaa ggataatcaa ttcccccatt gtcccaaacg cgtaatagcc 770941 tgattgaagg tatgggatta gaccttcaaa aacaggtgtc aagttttgaa gctcaatttg 771001 tgtggccagc gtaaatggaa ggaacaagac caggatgccg aatggaaata ggaatatctg 771061 cgccattctg gtcaatgttt cttttccctc tctggcaata cagatcgcca caaagataat 771121 aacaccgcca agaacagcca ttggtgttct cgggagaaat aaaatgttaa tcaaattgat 771181 gaaaaaacgt atatcatgag cattgattaa caggaaatac aaagaaaaca gtaaaatgat 771241 aatccggcct gcgattggtg aggaatcgct cagcagctca tagatatttt tatcctgatg 771301 ctttttcatc agcctatgca tgagccagag tgccggaatc acgatgacaa cgccgaggat 771361 gtagctgtgc caggcatttt gttttgctga ttcgatcatg agaatcggag catgctttaa 771421 tccgactgct aacgtataca gagctccgaa aaataatcct tggtatgcag aggtcttgtc 771481 cataaagcac atcctttctg tcatgttcaa aacggaatat atttaaacag gtgccccagc 771541 cgcggaagca ggggattcac tctcatataa atccatagaa aagcacttcc tgcaattagc 771601 aggctgaagg cccattttgt tagattgtta gcggaacgaa aattcttcca ttcatatgcg 771661 tatatggcaa tgcacacaat caatgtctgt acgatatagc tgatcatgct gacgcacctc 771721 cattaatggc tgatcgtttt gtataggaca ccgccctgct caatcgtcac aattgggacg 771781 acgtgaacct ccatatcctt atatacctct tcccattcct ttttcagcag attcttcgtg 771841 gttgccgtgc ttctgatggt cctgtcttga aagccggccg ggtccgcctt tagcttttgc 771901 aaacgatgaa cggtgctgat cacgtccttc tttatggttc tgtttaatgc tttttgaatg 771961 atgtaatact ggtcattttc tctcgtctca taggttgatt ggttttccat aataattcct 772021 ttggctctga tctcgattgt cattgacagc tttccgtttt tttcagcggc atgaaaggat 772081 gcattggact tttgaagctg aatggatgct tgccccattt gattcggcag gtctactatg 772141 aattctggct ggcgggcttg attcagcaac atcagggctg ctgtcatgtg ttcatctttg 772201 aaaatatcca tcaatctgtc ctttttaaag atcgcaagcc cgtcaatttt caaattagat 772261 ttgcctttcc ctccaggttt tgttttagat gcagagatga ccggtgcata cggatcactg 772321 cctatttcta ctagatcaga catgaatctg cttaagaaaa cggggcggct cgttgcgata 772381 atggccagct cccgaatcat ttccgccgga aactgttcaa gctgaacatc ggtatttaaa 772441 atgtcccgcg cttctccccg gctgactaaa atgagcgccg ttaatctgtt ctgcggattt 772501 cgcgttaaaa tatcaaagac tggggcaacg ccgtctctcg ccatatcctc tccaataatg 772561 actgtacgtc tgtgggacgt attgattgtc cgtgacaagg aggtttgcag cttgttgttc 772621 gcttctctga tcgtagtgcc ggaagctgaa tcaacatacc atgtttttga accggcagtt 772681 ccgccgccgc cccctgtttg tccgcctaat tggccgacca agggaatctg catggccact 772741 cgatactgat cttttttctt atcaatggct gagctgacaa caaatgcaat gtcattgatt 772801 tctgtccggt cccagcaccc cgttagaagg atacaaatga gaagcggcaa aacacactta 772861 tatattgttt tcttcatctt ttgggtcctc tcttttcgct cccttctgtc cgttgccgcg 772921 cgaatacgtg cccggccttc tggtcatcgt ccaccaaggc gccctgacaa aaatatcttt 772981 tacttcatct cgtttaaacg gagaaatccc ggataaataa ggaatgccga aagattgcag 773041 cttgcataaa tgaagcacta agataatcgt gccgagcata atgccgaata tcccaaaaat 773101 actcgccaaa aacataagcg ggaaacgaag catcctgatg gagatagcta agttaaaccg 773161 cggaattgta aatgacgcga tccctgttaa cgatacgatg atcaccatgg gggcagacac 773221 aattcccgct tcaacagcgg ctgtcccaat gactagggcc ccgagaatac tgacggtctg 773281 gccgatggtt ttcggcaggc gcactcccgc ctcacggaga gcctcaaaag aaatttccat 773341 aatcaatgct tctatgatgg cggggaaagg aatcggttca cgcgcagagg ccacactgaa 773401 cattaagttt gtcggcatta agtcctggtg gtatgtaata acggcaacat aaatagccgg 773461 caaatataaa gcaacgaata aaaacatata gcgaagccag cggattaagt tagacatcaa 773521 ataacgctca tagtaatctt cactggcctg cataagctgc caaaacgtaa tcgggcctgt 773581 taagacaaag ggcgtattat ctgtgaaaat ggcaaatcgg ccttcgagaa gctgggcggc 773641 gacggtgtcc ggcctttctg tgtattgcag ctgggggaat ggcgagtacg tgtcgtcttc 773701 gataaattct tcaatatatc cgctttctaa gacagcatca atctttatct ttttgattct 773761 tttttttgct ttgtcaataa cctttggatc ggcaagcccg tcaatatagg ccaagacaac 773821 atcggttttg gttttcgtgc cgattttaaa agagatcatt ttaagctgaa acgttttgac 773881 gcgaaagcgc acaagagcgg tattgaccct gaggctttca gtgaagccct ctcttgaccc 773941 tctgatggtc gattctgtta tcggctcttc aatgcttctt ctttgtccgc cttttatatt 774001 taagatcagg ccttttgagt gcccgtcggc aaataaaacc gcgttcccct caatgatgga 774061 tgcagccact ttgctcatac tcgtttctaa tgcaacactt gaaattgata gagtattttg 774121 cagcgcctct tcatgttcat ctatttgatc cgtcaaatgc attaagaaag ggcggagggc 774181 gtgatcctga atatgttcag attttacaat tccttcgata taaacaataa atccgcacag 774241 cccgtttcca aagtcaaatt gtctaaatac gatgtctgag cagccttctg ttaataaggt 774301 cagattttcg aggttttcct tcaaattggg agagatcggt ctgtcctgat tgtcttcaag 774361 ctctttgatg agctgaagcg ctttgtcgcg tttattcata gaggctcacc ctgcttttta 774421 atgtcatatt caataagtgc ttgtgacttt tagggtaacc ttgtctgttt catatattcc 774481 agactaggat gaaagcgcta taaaaaagtg ttgactacct gtatatacag gaatacaata 774541 tgattataag ttgtatatac aagttataaa aacggatacg gaggggttgg catgggggaa 774601 ctgaacaaat cggcacgtca gattgtcgaa gcagtcggcg gtgctgaaaa tattgcagcg 774661 gcaactcatt gtgttacacg tttgcgtttt gctttaatag atgaaagcaa ggttgaccaa 774721 gagatgcttg atcaaattga tgtggtaaag ggatcattct cgacaaacgg acagtttcag 774781 gtcgtaatcg gccagggaac tgtcaataaa gtatatgctg aactggttaa ggaaacgggg 774841 attggcgagt caacaaagga tgaagtgaag aaggcctcag aaaaaaatat gaatcctttg 774901 cagcgtgctg tgaaaacgct tgcagatatt tttattccaa tattgcctgc gattgtcacg 774961 gcgggtcttt taatggggat caataacatt ttaacggcgg aaggcatttt cttcagcaca 775021 aaatcgattg tgcaggttta tccgcagtgg gcggatcttg ctaatatgat taacctgatt 775081 gcaggcacgg cctttacgtt tttgcctgcg ttaatcggat ggtctgccgt caagcggttc 775141 ggcggcaatc cgcttctcgg cattgtgctc ggggttatgc tcgtgcatcc tgatttgctg 775201 aatgcgtggg gatatggcgc ggcagaacaa agcggagaga tcccggtatg gaatctattc 775261 ggcctagagg tgcagaaagt cggctatcag ggccaggtgc tcccaatttt gcttgcttct 775321 tatatgctgg cgaagattga ggtattttta acaaaacgca cacctgaggg catacagctg 775381 ctcgttgtcg caccaattac gcttctctta acaggatttg cctcttttat cattatcggc 775441 ccgattacat ttgcgatcgg taatgtactg acttcagggc ttatctcggt gtttggttct 775501 tttgccgcac tgggcggtct gttatatggc ggtttctact cagcgctcgt gattaccggt 775561 atgcatcaca cgtttcttgc agtcgacctg cagctcatcg gttcaaagct cggcggcacc 775621 tttttatggc cgatgctggc gctttctaat atcgcacaag gttcggcggc tctggccatg 775681 atgtttatcg tgaaggatga gaaacaaaaa ggcctctccc tcacatcagg gatttctgct 775741 tatcttggca ttacagagcc tgccatcttt ggggtgaatc tgcgatacag attcccgttt 775801 atcattgcaa tggtcagctc tggcctggcc ggaatgtata tttcttctca aggtgtgctg 775861 gcaagctccg tcggtgtcgg cggcgtgccg gggattttct caatcatgag ccagtactgg 775921 ggcgcgtttg caatcgggat ggctattgta ttgatcgtgc cgtttgccgg aacatacgcg 775981 tatgcgagat tcaaacataa ataacaagtg gggagcggga cgtgttgaac gttccctttt 776041 cccgttttca atttaaatat ggtggtggaa acagatgaaa acagaacaaa cgccatggtg 776101 gaaaaaagct gtggtttatc aaatttatcc gaaaagcttt aacgatacga caggaaatgg 776161 tgttggcgat ctgaacggca ttattgaaaa gctggattac ttaaaaacgc tacaggtgga 776221 tgtgctttgg ctgacgccga tttatgattc tccccagcat gataatgggt acgatattcg 776281 tgattattac tcgatttatc ctgaatacgg aacgatggag gattttgagc ggctagtgtc 776341 cgaagcacat aaaagagacc tgaaagtcgt catggatctt gttgtcaatc atacgtcaac 776401 agagcacaaa tggtttcgcg aggcgatctc ttcaatagac agcccgtacc gtgattttta 776461 tatatggaaa aaaccgcagg aaaacggttc tgttccgacg aactgggaat cgaaattcgg 776521 cggctcggca tgggagcttg acgaagcatc gggccaatac tatttgcatc tgtttgatgt 776581 gacgcaggct gatttgaatt gggaaaatga agaggtcaga aagcatgtct atgacatgat 776641 gcatttttgg tttgaaaagg gaatagacgg ctttaggctt gatgtcatca acctgatttc 776701 taaagatcag cgctttccga atgcggagga aggcgacggc cgctcttttt acactgacgg 776761 gccgcgggtg cacgaatttc tgcatgaaat gaacgaaaag gtgttttcac attacgacag 776821 catgacggtc ggtgagatgt cttcaacaac cgtagaccac tgcatccggt atacgaatcc 776881 tgacaataaa gaacttgata tgacattcag cttccatcat ctcaaggttg actatcctaa 776941 cggcgaaaaa tgggccttgg cgccgtttga ttttttgaag ctgaaggaga tcctatctga 777001 ctggcaaacg gggatgcacg caggaggggg atggaacgct ctgttctggt gcaatcatga 777061 tcagccgcgc gtcgtatcaa gatatggaga tgatggcgca tatagggtga aatcggcgaa 777121 aatgcttgct acggccattc atatgatgca gggcacgcct tatatttatc agggcgagga 777181 gctggggatg acgaatccga agttcactga cataagctcc tatcgggatg tcgaatcgct 777241 gaacatgtat cacgccttta aggaaaaagg aatggctgat caagatatta cagccatttt 777301 acaggcgaaa tcccgtgaca attccagaac ccccgttcag tgggatgcta cggaaaatgg 777361 tggttttaca acgggcacac catggatacc ggttgcagga aattaccggg aaatcaatgc 777421 tgaagcggcg ctgagggatc agaattcggt gttttaccat tatcaaaaat tgattcagat 777481 tcgcaaaatg tatgacattg tgacagaggg tacgtatgag ataattgcaa aggatgaccc 777541 gaacattttt gcgtatctca gacacggcag caatgaaaag ctgctcgtga tcaataattt 777601 ttacgggaca gaggcggcct ttacactgcc ggactcttta gcgcctgacg aatggaaggc 777661 agaggtgctg ttgacgaacg atgaagcaag ggaagggctt cagaacatga cgcttcgccc 777721 atatgagtcc attgtttatc gtttaacgaa accgtgttaa actaagctgg gtggtccata 777781 atgaaggtga ataaattcat cacaatttat aaagacatcg cacagcaaat tgaaggcggc 777841 cgatggaaag cggaggagat tcttccgtct gaacatgagt tgaccgcaca gtacggtaca 777901 tcaagagaaa cggtccgaaa ggcgcttcat atgctcgcgc aaaacggtta tatccagaaa 777961 atcaggggaa aaggctccgt cgtgctcaat cgtgaaaaaa tgcagtttcc cgtttcgggc 778021 cttgtcagct tcaaggagct cgcgcaaacg cttggcaaag aaacgaaaac aactgtacac 778081 aaattcgggc tggagcctcc gtcagagctg atccaaaaac agctccgggc caatctggat 778141 gacgacatct gggaagtcat caggtctaga aagattgacg gggaacatgt gattttggac 778201 aaggattact ttttcagaaa gcatgtccct cacctgacga aagaaatttg tgaaaactcc 778261 atatatgaat atatagaagg agagctcggt ctttcgatca gttacgccca aaaagaaatt 778321 gtagccgagc cgtgtacgga cgaggacaga gagctgctcg atttacgcgg ctatgaccat 778381 atggtcgtgg tgagaaacta cgtctttttg gaggatacca gtttgtttca atatacggaa 778441 agcagacacc gtctcgacaa attccgattt gttgattttg cgcggcgggg gaaatgagag 778501 aggcgcctgc ctgcggcagc gcgctttttt gtttggtatc aaaattgata ctatccaaca 778561 aaaatgtgcg tacttttact ttttatcata atggctacaa tagagatgag agtaatctaa 778621 aggagaggtg ttttacatgg cagatctaaa gacacaaatt ctggatgcat acaatttcag 778681 gcatgcgact aaggaatttg acccgaataa aaaagtgtca gacagcgatt ttgaatttat 778741 tttagaaaca ggaagactgt ctccgagctc actcggcctt gagccttgga aatttgtcgt 778801 cgtccaaaat ccggaattcc gcgagaagct tcgtgaatac acatggggcg cgcaaaagca 778861 gctgccgacc gcaagccatt tcgtcctgat tcttgcgcgt acagcgaagg atatcaaata 778921 taatgcggac tacatcaaac gtcatttaaa agaagtaaaa caaatgcctc aagacgtgta 778981 cgaaggctat ttaagcaaaa cagaagaatt ccagaaaaac gatttgcatt tgcttgaaag 779041 tgacagaaca ttgtttgact gggcatcaaa acaaacctat atcgcgcttg gcaacatgat 779101 gactgccgct gcgcaaatcg gtgttgattc ctgcccgatc gaaggcttcc agtacgatca 779161 cattcaccgt attcttgaag aagaaggcct tctggaaaac ggaagcttcg atatttctgt 779221 gatggtggca ttcggctacc gagtgagaga ccctcgtccg aaaacaagat ctgctgttga 779281 agatgttgtg aagtgggttt aaaagaagaa agctgctcgc atagcgagca gctctttttt 779341 atgcctgatt cgctctattc tgttttctcc tctgatgtaa gtacattgcc gttccgagtg 779401 cgctgatcag aaatccggcc aacaggatcg agtacatgga tgtggctgtg tccggaagca 779461 ggccgccagc cggaccgtct gttcctgatc cgcccgaacc gtttccacca gagccgttag 779521 tcggttgagt gccgggaggc gtatcatttc ctccgtttcc gtcagttggc tgttttccgc 779581 ctggtttgtc ggagcctccg ccatgattgc cgtcatcacc gcctgtcggt tgatctgacg 779641 ggaatgccgg cggtttgttg tttgaaccgg aatttaagat cgtgtattcg ctgaagtggt 779701 ttgtatatcc tgtcaccata tcatcatcga ctgatccgtg acctgtcttt gtgaaagctt 779761 tcttttttct atcgacgtga taaatggcag ggttatgggc ttcttcaata tcaaacatgc 779821 gaagcgaaag ctgtacgggc tccttgaatg attttatttc ttttcctttt tgcttcactg 779881 taaagtcata tacatctgac agtgacacat ccaattctcc cgtagacttg attccgattg 779941 cagtgtctgc ggttttaagg ttcgccattg gcatcttcat gctgtaccag tagttgaaca 780001 tcgtcaatga aggatctgac tctctttctt tcaaaagttt gacctgatct tttttcactt 780061 taagattgat aggcttctct tgagatcctt catgtattcc ataatagaca aatggcgtgt 780121 tggcattttt agcataaatc gcaaatttgt cttcatcaag tgtccagctg ccgtccttct 780181 gctttgtcgg caggaatact tctttgattc gtccttcaac tttaggagag accttgtttc 780241 ctagtttttt cagctgttcg gtgaaaatct cataatcaac gtagccaagg tcttcaccat 780301 gggaggcttc tgtaaagaca gaatatccgt ctcctccggc accgacaaaa ttatttgttg 780361 ccacgcggta ggtatcatcc gtatttatag caactttgtc tccgttaggc gattcaattt 780421 tcacttctaa cacacggtgt ccaggtttgt tgtttaatgt aaaggtatat tcgattccgg 780481 ccacctgagg gaaagcgccg ccgccatttt ccacattgct taggccttgt tcaagggctt 780541 ctttaatttg ttttccggtt aaatcggcca cgtaaagcgt attgccgaac ggcatcacgt 780601 tgagcacctc gccgagtgtg atatcacctt tgtcaatgcc tgctctgatg ccgccgccat 780661 ttgttatcgc tattctggcg ccggctgctt ctttcgcttt tgccagcata ccgtccgcga 780721 tgaagtttcc gagattcgtt tctttcgtgc gcacatgctc acgctggccg tcaagcgcca 780781 catccgtgta gccgactttt tcatttttca cgtcctctaa ttcatttttg aactgatcga 780841 gctcttgttt tgcttctggg ttttcttctg tatgttcatc aattggcagc acgctcagat 780901 ttgatttatc tgtttgcaca acgccttttt catcaaacgc gacatcaacg cgccccaaga 780961 attggccgta ttcttttgcc tgcgccacga tcgtcggttc ttcgttgttc acgacctcca 781021 ttttgtctac gagggtgtga gtgtgtccgc cgatgatcaa atcaatgcct tttacttttt 781081 tggctagctc aagatcccgg ttatgtccga tgtgggttaa agcaataatt ttatttacct 781141 tttcttcttc ttgaatcgct ttgacggtgt tttgtgctgt ttcaaaggca tcattgaata 781201 cgatgctttt gcccgggctt gatgtggtgg ctgtatcttc tgttgtcagg ccgaatacgg 781261 cgactttctc cccgtcaacg tctaacagaa tgtaagggtg aatgccggcc tctttctttt 781321 cacctgccgt aaaggtttgc ggctttttga caaatgattt cagcttgggc tcatttgaca 781381 catctacgtt tgcactgaca atcggaaatt ccggcgcttc aaagtgatag cggttcgccg 781441 gatcaacggt tgcgctgttt ccgcttagaa aatcagaaag caccgtcggg cctttgtcaa 781501 attcatggtt tccgaaggtc atggcgtcat agcccatcat gttcatcatt ttcagatcgg 781561 ccaaaccgtt ccatttagta aaatacagat cgccggaaaa cacatctccc gcatcaagga 781621 gaatattgtg atttgtttcg ctgcgtactt cgttgatttt cgtcattcgt ctcgctgcat 781681 catcgagatg ggcgtgcgta tcattggtgt gcatgacggt cagatcccac agtccgtctt 781741 taggaggatc tggatttgaa tcatcatcga attgcagctt atacacacca tagccttcat 781801 tcgcagactt gcctacataa gcgacatcgt ctgctttatc ggcaaatggc ttggccaaaa 781861 gcgaggattc aaacgtcaga ttcgtgccgg aaacaggcgc gattgaccag ttgttgtctg 781921 cttttggatt gactgttttt tgttcaataa tgtaatccat cagcacctgc ctattttcaa 781981 ctgcagagcc gtggacaatt ttatcgctcg tcagatgagg gaacccgccg cctccggacg 782041 cacgatagtt attggtgact acgagaaatt cctggcttgg gctgatcggc ttgccttcat 782101 aggaaagatt gatgatacgg gatgaatccg cattgatcac ttttccgttc tcattgtatt 782161 tagccggttt tgtcacatcg acctgatatg tgacaccgtc aatcacgtca aaattatagg 782221 agcggaaatt ctcgttcagc aaggcctggt cgccgccttt agctggatca atttgattga 782281 attggcctgc tgacatctcc agccagtcct tgacctcgct gcctgtcagc ttgacgattt 782341 gaacagtatt atcgtaaaga tacaagtcac cgacattttt aatcgcaaga tctccggctg 782401 gaatgtttgt atagtaattg gctccgtttc tgccgcctgc tttaaacggc gctccagcgg 782461 ataaaatcgg caggttcttg tactcggtat ccttcatttc tttttcagcg taccactttt 782521 gcgcgtcagt cacgatctga atggaaggat catctttgac ctgtgcaaag aagctgttaa 782581 tatctgcttc ggttttgccg actggctttc ggacatactc cagtgtgttt tggtgtgttt 782641 gctgaatggt gtttgtaacg gtttcgtttc ttgatgtgac gttgccagca atagattcaa 782701 tacttccttt ggaatctgct accttccatg agccgtccgc cttttcaagc ttgaggtcaa 782761 tcacgcctaa atatttgccc cagctgcttg gcatgacgac aggaatgccg ttaattgttc 782821 ccttttccac attgaactga gcaacacccg catactcggc ggaaggaaag agtccgtgct 782881 gatggcccga gataatcgcg tcaatgcctt tcgttttggt ggcaaggtca aacacggcgt 782941 tttctgcgcc tgatgattgc gcctgctttt caatgccggt gtgggcgagg gcaataatga 783001 catctgcgcc ttccgccttc attttcggga tcgtttcatt ggcggattct acgatatcct 783061 gcacctgaac ttgcccctcg agattctttt tgtcccatgt catgatttgc ggcgggacaa 783121 agcctatgta gccgactttt actttctgct cattaccgtt ttcatcaatg agggtttttt 783181 cattaatcac atacggcgta taacggtttt cgccgctagt tgttttgacg ttggcattta 783241 caatcgggaa atcggctcct ttgattgtgc cgtcgagaaa gtcgagcccg tagttgaatt 783301 catgattgcc aagcgttccg gcgtcgtatt tcagcgcatt catgacgctg ataatcggat 783361 gggttttcgt gccggagata atgtcgtctt tttgatattt caccgcgtat tcacccagcg 783421 gattcccttg aatcaagtcg ccgttatcca caagcagggt gttagggttt tgctcgcggt 783481 gcttttggat caattgcgct gttctcgcca gaccgaaatc cgccgtttct ttgtcgctgt 783541 agtaatcgta atccatcatg ttggcatgaa tatcagtcgt agccaaaata ctcagatgca 783601 cctgaggagc cgcgctttct tctgcatgaa tgggtggtgt tgggaggatt aggctaagta 783661 tcataattgg gggcaaaaga atacggagaa tgttttcgac gtgtgttcgt cttttctgta 783721 ttctcaccag ttctccacct ttcaacgaaa tttgtgttac agctcctatt gtaagaatat 783781 tttgtaacta tttgtaggtg tttctttatg attattgtaa aagggagaaa aatgagtatt 783841 atgtagcagt atcaaacgac aaatactggg catttatgct tatcgtttgt cacaatcgcg 783901 gaatgtttat tttagtgtgg ctggggtaga gtgttttatg tagacatata aagcgggagg 783961 ttatgaatca tggggaaaaa aattgcagtt gttttaacat attattttga ggacagcgag 784021 tacactgagc ctgcgaaagc ctttaaagaa gcgggacatg aactgactgt catcgaaaaa 784081 gaaaaaggaa aaacagtaaa aggcaagcag ggaacagcgg aagtgacggt tgacgcgtcc 784141 attgacgacg taaattcttc agactttgat gcgcttttga ttcctggagg attttcacca 784201 gaccagcttc gcgctgacga tcgtttcgtc caatttacaa aagcgtttat gactgacaaa 784261 aagccggtat ttgccatttg ccacggcccg cagcttttaa tcaatgcgaa agcgctcgac 784321 ggccgaaaag cgacgggcta tacgtccatt cgtgttgaca tggaaaacgc cggtgccgac 784381 gttgtggaca aggaagtggt tgtttgccag gatcaattgg tcactagccg cacaccggac 784441 gatataccgg catttaaccg cgagtcattg gcattgcttg agaaataaga aaaaacggac 784501 gctcttgggc gtccgttttt ttgttgctta ggcttgagca cctgtcagtt tcttgtacct 784561 gtaatacaag aaagcagctg cagccgttcc gatgaccgca atgccgaagt cgaatatgaa 784621 aatatgggcg atgccccccg cttttgcgat aagccctgtt gcaatcggca gcagaatcga 784681 tgcaagactt gaagcagtcg ctacaattcc ggtaacggtt ccttttcgct tccagaaaag 784741 ctctgtcatt aacgtaatgg taatttgaaa cacacccgca gttgaaaagc ctaagaaaaa 784801 ggcagtgatg tccagcacaa ctgggatatg aacggtcagc atgactgcga gcgtacataa 784861 agtaataata ggatataaga gcgttatgaa gacaggtttg acccatctat tcagcaaaac 784921 ggctaataat aaaacagatg ccagagatcc tatactataa tagctcagca attgtacaga 784981 tgctgattca gctaaaccgg ctgccttttg cgcgtagctc gggagccaga tttgagaaac 785041 cgtaaataaa gccgtggatg taaaaccgat gataatcagt gcggtgcctt ccttctgaaa 785101 aacgggttca gacaagaaaa cgggagattc ctgttggccg ctattagttg gtttcttatg 785161 ttttttagga aacgaaagcg ttgataaata aataatattc aggagataga ccgctgccgg 785221 cagataaaaa gcaaatccgt aaaacatgct gtggtctgct aaaaatgtga tcaaaagcgg 785281 caaaagtgcg gcccccacag acataaaggc tttaaccaag acatttgccg aaccggaagc 785341 agacggaaag agctcggtta gggccggata tgttccggca tccatggctg aattagcgac 785401 tccggctaat aaagcgaaca caaacgccag ctcatagctc ggtgataaag gaataccgac 785461 taaaaagacg gccataattc ccgcagaagc gacaacaagc ggctttctgc cgattttatc 785521 tgatagaacg ccggaaatgc cgtatgtcag cagtttgcca aacccgatag cggcaatgac 785581 ataactgatg ccggtcggat cggtattcca ctgttttgtt aatgaagaca tattggatgc 785641 gagaatgatg ttgaccatcc ccagaaagaa gtagttgata tacattccgg atgctgtttt 785701 gatagatgtc gtttgcatgc ttgtactcct tcaaatctta ttcgaacact ttgctgtttt 785761 ggtttgggga aatgataaaa aagactcgcc gagtttccgg ccagtctcca ttatttacga 785821 agcgaggcta attcttgagc aatcgcctgc atttcacttg ggctgaatga ttcttttttc 785881 atcaccattc tgtgaaggta cgtgaggtct tcaatcttct catcactgaa atcctccgct 785941 ttgattacgc cgacgttcag catgttcagc ttttgggaaa tctcttcaat catttgagtt 786001 aatgtttctg tatttgggct ggacaaaggg ttccatcctt tctatgcgca atataggtat 786061 gttttattct aacagaattc catcagaaaa aaaccctatt ctaaaagcag gctgttcatt 786121 ccaaaaaagt gaagacatca gttgaaaaga aaatgaacat cctactaaga tattcatgaa 786181 ggtttctttt tagagaaata ggggcaaaga atagggaggt tgcacatcat gataagcgtg 786241 ttatttgttt gtttaggtaa catttgccgg tctccgatgg cggaagcgat ttttagggac 786301 ctggcagcca aaaaaggatt agaggggaaa atcaaggcgg actcagccgg tattggcggc 786361 tggcacatcg gcaacccccc gcatgaggga acgcaggaga tattgcgcag agaaggaatc 786421 agctttgatg gcatgctggc gcgtcaagtc agcgaacagg atctggacga ttttgattac 786481 atcattgcaa tggatgcaga aaatatcgga agtctcagaa gcatggcggg ttttaaaaac 786541 acctcgcata tcaaaaggct cttggactat gttgaagatt cagatctggc tgacgtaccc 786601 gatccttact acacagggaa ctttgaagag gtctgccaat taatcaaaac gggctgtgag 786661 cagttgcttg catccattca aaaagaaaaa caattgtgag tgaaaggaga atttgcatga 786721 acaacgaacg tttaatgctg aaagggatat ttctcggagc tgcggcaggc gcggcgttat 786781 cactgctcca taagccgaca agacaggcgt gcgggatgag atggctgaca tgcaagcata 786841 aactttcact gtacaaaagc aacccagagc tgttaaaaaa cactgtcatc acaaaagtgg 786901 atgaggccaa aaagctcgcc cgaacgcttt caaaggaagt cgactttgtg aaccagcagg 786961 tgaaagagct gaagaaaaca acgccgcaag tgatggaact cgtgcaagaa acgaaagagc 787021 atttttcaaa aaaatgatca aacatgcgag gtgagacgac atgagttttt tgaaagagct 787081 tttcagcaga tacacccttc atgaaggaca aagtaaatca gcggagctgg cgtatttttt 787141 tctattgtca ctgtttccgt ttttgatttt tatgctgacg ctcaccgcgt atcttccgct 787201 ttctaccgat gatgttttag gagtcataga acaatatgct cccgccagtg cgatgtcact 787261 cgttgaatcc attacccatc aaaccttaaa taatcgaaat ggcggtttgc tgtcattcgg 787321 gattatcgcc gcattatggt ctgcgtctaa tggaatgaat gcgatcgtcc ggtcgctgaa 787381 ccacgcgtat gatgtggaag aaaaccgctc ttttatcatt gttcgtctaa cctcgatttt 787441 tttgacgatt gccatggtat ttacgatttt agtggctttg cttctgccgg tatttggccg 787501 ggagattgga aggctcgctt ctgactttgt cggcgcgtcg gatctgtttt tatccgtctg 787561 ggccgccatt cgctggggtg tcagcccgct tgtgcttttg attgtttttt ccgcgctgta 787621 tgtgattgcg ccgaacaaaa agctgtctct ccggtttgtc atgccgggtg cggtctttgc 787681 gactatcggc tggatcattg tcagcacatt gttttcattt tacgtcagca cgtttgcgaa 787741 ctatagcgcc acttacggga gcatcggggg aatcatcgtt ctgatgattt ggttttactt 787801 gagcggcatt ttaattatcc taggcggaga aatcaacgct cttttacata aacgtaaaaa 787861 gcttcctgat gaaaatccct accattagcg caccctataa acgaacttcg gttcaaaaag 787921 aagtcggggg gatatcgtga tgaccaagca tacgaaaaaa ggcggaagcc ataacaaaca 787981 aaactcgaaa agcaaatcga gccataaaac aagcggaagc gccaacggac aaaacggcta 788041 ccattagcat aaaagcctcc tgacatgatg tcgggaggct ttttgattaa gaagatgaag 788101 aataggtttc agccggtgac cagcttttcg gtttgcccag cacaagggcc agccacacag 788161 agctaagcgt gagagtaatg aagtagaaca agtttgcgct ttcaaatgtc tgcatatacc 788221 agccgccggc aactgggccg aggatgctac cgagactgaa tgtaatgccg caaagcaggt 788281 ttcccgccgg caggaggtga ggcggaagaa ggtctgtcat atagctgatg ccaagtgtaa 788341 aggttgatcc gactgccatt cctgcaataa aaaagcagcc gccgatcacg tagggcgaag 788401 gaaatacacc ggcgatgaaa aagcaaagag ccccagtcag taaaatcacc agcagcacat 788461 tccgcctgcc gtatttatcg ctgaggatgc cgagcggaaa ctgaaagata atgcttccaa 788521 tcgcaaatgc gggaaggatg atcgctactg cgtctactga tatccccaaa cggagcgcgt 788581 acaccggaaa gcttccgttc agcgccgttt ccagaaagcc atagccaaat gtaggcataa 788641 aggcaaccca cccaaacagc atggcctgat aaaatcgcct gaaactattg tctgatttgg 788701 tttcatgagg actggtttcc gggtatgcat tttgtagaaa gaaaacaaaa agccacgcaa 788761 acagactgat gcagccggac acgataaaag gaagcgacgg actcagcttg acaagcggca 788821 ccatgaacgg gcctgcggca aagccaaggc caaaggaaag cccataaata gacaggtttc 788881 ttccgcgatt ttgttttgat gacatggagg tcacccacgt ttgcgtagaa aagtgaagca 788941 tgtggtcgcc gattccaatg aacaggcgaa gcaggaacca gacccaaact gactgaagcc 789001 aaataaatcc gaataagctt aaaatgacaa tgcttccgcc catgacgatc agcggcttga 789061 acccgagctt tctgagcggt gcttccataa acggcgaagc caaaagcaca ccgatataca 789121 gcccggtcgc gtgcaggccg ttgatagcag cggattctcc atttgtttca aaaatgattg 789181 aaatgacagg cagcagcatg ccttgtgaaa acccggaaat ggaaacgagc aagacaagga 789241 taaagaaatg aaatcgtgac atcgtgtcag ttctccttat atggaatcta tgttgatcgt 789301 acaacgtttt ccaaaagcag gcaacctgaa aaaagcctat atcacgctat acatttgccc 789361 tcgtgtaatc atgaaggttt ttgtgaagaa taaaaataaa acaagtcata aaaaaggagc 789421 tatttcacca tgaatcgtat cttttttatt ttagtggcgg ccggtgttcc gctttctgtg 789481 attggcagtt tgatgcattg gccttccgcg gttctatttg cagtttattg cgtgacgatt 789541 atcgcgcttg caagctatat ggggagggcg acagaatcac tgtccatcat tgcaggaccg 789601 cgtatcggcg gtttgttgaa tgcaaccttc gggaatgcgg tggagctgat tatttccctt 789661 tttgcattaa aagaaggcct gacaggaatc gtgcttgcct ctttaaccgg ttcagtgctg 789721 gggaacctgt tgctggtagc gggcctatcg ttttttgtcg gcggtttaaa atataagcgg 789781 caggaattta atatccatga tgcccgccat aactccgggc ttctgatttt tgccatcatt 789841 gtcgcctttg tgattccgga ggtattctct gttggtatgg gaaacgccag caagctcaat 789901 ttaagcatcg gcatcagcat cattatgatt ctgttatatg tggcggcgct gtactttaaa 789961 cttgtcacgc atcggggcgt ttatcagccg aataatgccg ctcagactga agaagaggaa 790021 gagccagaat ggtcagggaa ggttgcgacg attgtcttgt ttgcggcaac gattgtggtt 790081 gcatacatat ccgaaaacct ggtccatacc tttcactcgg tggctgaaca gttcgggtgg 790141 agcgagctgt ttattggggt catcatcgtg gcgattgtag gaaatgcggc ggagcatgcg 790201 tcagcgatta ttatggcctt caaaaataaa atggacattg ctgttgaaat tgcagtaggc 790261 tctacgctgc agatcgctat gtttgtcgca ccggttctcg tcatctgttc tatctttttt 790321 ccgacaagca tgccgcttgt atttacattg cctgagctcg tcgcgatggt atcagcggtt 790381 ctcttgatga tcgcgatttc gaatgacggg gattccaact ggtttgaagg ggcgacactg 790441 cttgctgcat atgtcattat ggcgatcggc tttttccttc tttaacctga aaaaatgatg 790501 gataacaaca aagcgggatg aaaagactaa gggaaaatgc catagaaaga gtgatatgat 790561 gaaaaagcta tttcattcca cacttattgt gttgttattc tttagttttt tcggcgttca 790621 gcccatccac gcgaaaaagc agtttaaggt tcctaattct gtcgcaagca tttcaaagga 790681 aaacacgtat ccgaatgctt cacaggatca gccaatgctt cagccgagca agctggcaaa 790741 ggaattgctc gatcattctg aggtaaagat tgaaaatccg catctcatca aaatgctgaa 790801 tgaatccaac atatccggca caccgcttgc agtagggtac cgggcgacaa tatttctcgg 790861 gaaatgggcg ctcggctatg aatcaaatga aacagtcgca aactgggaat ataaaaaaat 790921 caatacaaac cgtgcggata accgcggcgg gaaagaaacg gctgaaatgc attatgccca 790981 ggaacagcag tacagagtga agggcggctt gacagctaaa gttccaaatg ctgaagatgt 791041 caaaagcatg atgatgcaaa aagcaatgaa gaaaacgaac ctcccgcttg catttgagac 791101 ggtcatcggg gctggcacaa aacgggatca gatttataaa gtcgctccta aaaaaatcgg 791161 ttatctacat gcatatgcac cggctgtgaa tgaaaaagga aaagtgactt acggagaagt 791221 gtacttagtg ctgaaaggaa ataaacgaaa actcgtcgtg aaaaatgtca cgtcacaggg 791281 aatcggcgcg tggattccgg ttcaagatca tgtcacgttt ggctttcagc tttcctcact 791341 gccaagataa ataaaaaact gattccaact cggaatcagt ttttttgttt attgggttct 791401 ctcgattcgg accgcttcct caagcatttg cacattgttt tggtagagct ggcgaacgag 791461 aacccgtctt actgcaaggc tggcactgaa ataatcatca tctttcacca tgcctttaac 791521 cgtaaattcg acgccgcgat tgattttatt caatgcggtg atgccgtgga tttgaaacgg 791581 ttctgtcgga ttgccgaatt catcccgctt caatgaatca cgaagctctt cattcagcat 791641 gtcacatgcc tcttccaaca cgctgtacac gcggtccgga tcttctttaa agctgataag 791701 aaaggattcg gtaatccgca taaaatcaat attatagttc tctatttgtc tgacctcgcc 791761 gttgctgatg gtgagcagct tcccgctcca ttcccggatt tgcagcgagc ggaggccgat 791821 ttcctccact gtcccgttga acaagttgtt gacggtgaca taatcgcctt tgtgcagctg 791881 gcgttcatat attaagaata caccagccag cacatctttg atcagcgatt gggcgccaaa 791941 accgatcacg atacctgcta cgcccgcccc ggccaatatc ttgccgaaat catgcacaaa 792001 taaagaaata acgtaaaaga taaaaccaat tgttgccgta tactgggtga cagaacggac 792061 aaggctttca atcgtttttt cctttttttc ttcaataaag tccgtccgtt taaaaaatag 792121 ctgtaccagc cggttgatga taaagacacc gatccaaagg ataacggcaa cgaggagaat 792181 atcgacgatt ttattttgaa aaatctccgt aagtgtttct ttcatccgca tctaactcct 792241 ggcttgacgt tttgtgaagt ctgtatcctg ataataactg tttttgacaa gaacattcgg 792301 tccgaggcac cggacattcg ggcagtggca actcagttct ttcgcaagct tggtctctct 792361 ccacttttca taggcggaag ggaggctgtc cgtctgaatg ttgccaagcg gcggggtatc 792421 accgaaatcg gtcacgataa tgtttccgtc gaaaatgttc acattcaggc gggatcggcc 792481 gtcagggtca tttcgcactg tgacgttttt cgccgcgcga agccggcgaa gcagcttttg 792541 gtcgtcttcg tccggactgc aggcataaaa cggcagcgtt ccgaacagca tccacgtatt 792601 ttcatcacga atatccagca agcggtgaat ggcctgtctc atctctttca ggctgaggga 792661 ttcaagagcg cttgcgaaat cgcttggata cattgggtgg acctcgtgac gctgacattt 792721 catatcttct gtgatttggc ggtgaatatg ctcaatatgc ggaagtgttc gtttgttcag 792781 catcgtttcc gcagatacca ttactccggc atccacgagc gtgcggctgt tttcgatcat 792841 tttttcaaaa tagcgcgcgc gctgttcgaa ggtcggtttt ctgtccatca tggcaaagcc 792901 gatttcagca aaatcttcaa ctgttcccca gttatgtgaa atatgtagca catcgagata 792961 cggaatgatc cattcgtacc gctcgatgtc gagggtcaga tttgaattaa tttgtgtccg 793021 cacaccccgt tcatgggcat atttcaataa aggaacaaca tattctttta ctgatttcaa 793081 cgaaagcatc ggctctccgc ctgtgatgct gatggatctg aggcgcggga tttcctccag 793141 ccgttttaac agaagatcta ttggcagagc attcgggtct ttaggctgca atgtatagcc 793201 tacagcacaa tgctcgcatc tcatattgca cagtgtcgtt gttgtgaatt caacgtttgt 793261 cagctgcatg tctccgtatt ggtcaacatc catataggct tcccaagggt caaactcggg 793321 cgtaatcgga cgcagcttcg tgttttgtgt catgactatc taactccttt ataaatgggc 793381 atactaacgc tgccaacagt taattttaga cctgatttgc caagatcgca agtagcgcgg 793441 cgattgaaaa acggcaaaaa atgagctacc ataataaaaa atgaatggag gaacagaatg 793501 gggaacgccg taaacaataa agatcagcag attgattatt taaagaacag acttgacatg 793561 tttatgaacg tcatcgattc attagaccct gaagcaaccg acgttgaaga tatagacagg 793621 cttatcagca tgcttgatga cctggaagcc aaatacgaac gttttaaaaa agattgggaa 793681 taaaaccgcg tgcccgccgc ggttttttta ttggcataaa gcaacagtat aaaacaaagt 793741 ctctatctgt aaaataagaa aaaatgcaga aggagcgctg gccatgaagt ggatgtgttc 793801 aatatgctgc gccgccgtat tgcttgccgg aggtgcagca caggcggaag cggtgccgaa 793861 tgagccgatt aattggggct ttaaacgaag tgtcaatcat cagccgccag atgccgggaa 793921 gcagctgaac agtttaattg aaaaatatga cgcgttttat ttagggaata caaaggaaaa 793981 aacgatttac ttaacgtttg ataacggata tgaaaatggc tatacgccaa aagtgcttga 794041 tgtcttaaaa aaacatcgcg taacaggaac gttttttgtc accgggcatt tcgtaaagga 794101 ccagcctcag ctgatcaaac gaatgtcaga tgagggccat attatcggca atcattcctt 794161 tcaccatccg gatttaacga caaaaacagc tgatcagatt caggatgaac ttgattcagt 794221 caacgaagag gtttataaaa ttacgggaaa gcaggacaac ctgtatttgc gtccgccgcg 794281 cggcgtgttc agtgagtacg tactgaaaga aacgaaacgc ctcggctatc aaaccgtttt 794341 ctggtcggtc gcttttgttg attggaaaat caacaaccaa aagggaaaga aatatgccta 794401 cgatcatatg atcaagcagg cgcacccggg agccatttac ctgcttcaca ccgtatcgag 794461 ggacaatgca gaagcgctgg atgacgcgat tacagatctg aaaaaacagg gctacacttt 794521 taaaagcatt gatgatctga tgtttgagaa agaaatgagg ctgccgtctt tgtaaaagag 794581 aaagacctct ccttaaacgg agaggctttt ctttatttta tacatttaat cagtgcggcc 794641 cagtccagat ccccgaagcc tttctcaatc ccgctttcaa aatggctctt ggccagctcg 794701 gcaagaggaa gatttgcaga aacccgtttt gcggcggcga gtgccaggtt ggtatccttc 794761 agccctaaag acattttgaa gccggccggc tcaaatttct gctcggccat aatggttccg 794821 taattttgat agactggaga accaaagagc gcgctggcga tttctaaaaa ttgtttttgt 794881 tctaagccgt atttctccat cattaaaaag gattcagata acgcctccag catggacaca 794941 agcaagaaat taatgctgat tttggctgca tttgccgtct tgctttcttc gccgacgtca 795001 aatatctgct ggctcaggct gtcgagcaga ggcttggcag cttgctttgc ttccgccggt 795061 ccggctgtta tgatacggag cgcggctttg gctgcggcat ccggtctgcc aaggacagga 795121 gcggcgagaa aaaattgtcc tttctctgca tgagccgctg cgagcttttc tgagaactca 795181 acactgattg tgctcatcga gatgtgtatg ccgttctctg ctaatccttc aagcagcccg 795241 tcttctccga atgtcacggt gctgacagaa tcatcatctg caagcattgt gatgacaata 795301 tcagcggact ttgccgccag ccgcggcgta tcagctgcct gtgcgccttc tgtgacaagg 795361 tcttctgtct tttgtttcgt ccggttatag acagtcaatt cgtagcctgc ttgaagaaca 795421 tttcgggcaa tgggctgtcc catattgccg agtccgatga cagcaatttt caatctaatc 795481 actccctgaa tattttttcc attataaaca atatgaacag aatatgcata gcgatcggct 795541 tacaacaaaa aagaacagct gctcgctgtc ctcatttaaa aatattgaac catcctttat 795601 gtacaaacca aatcagcatt ccaatcacaa gcgcggccat caggccaagt acagcgaaat 795661 atccgtattt ccaatgcagc tccggcataa agtcgaagtt cataccgtat acaccggcaa 795721 taaaggtgag cgggatgaaa atggttgata cgatcgtcag tgtcatcata atcgcattca 795781 tccggtttga gtttagcgtc acgtagctgt cacgcaagtc ggacgtcatg tcacggttgg 795841 attccacaat ttcagacaac tttaacaaat gatcatatat gtcgctgaaa taggctttcg 795901 tttcccgctg ctctttcaca tggtcaaggc ttaaaatccg gtagagcaaa tcacgcatcg 795961 ggataatcgt ccgtctcaaa tgcaataggt ctgttctgag atcaaacacc tcgttcatca 796021 gcgttccata cgttttgtgg ggacggcttt cttcaatttc attcagccgg tcttcaattt 796081 tatacacgag aggaaaatat tcatcaacaa gctgatccat gatcatataa gaaatatgcc 796141 cgggcccttt tttcaatatg tccggtgaag catacaaacg ctcccggact ttagcgatac 796201 cgggcgtttc gtgtaaatga aaggtgacga caaatttttc gccttgaaag atatcgactt 796261 cctccgtctc aagtgtttcc ttattcagcg catgaatcac gtaaaaacga tagccgtcat 796321 aatggtcaag ctttggccgc tgcatatgct ggaagcaatc ctcaatggca agcgggtgaa 796381 aatgaaaaaa atctctcaat aacgccgttt ccgtatcctc cgggccgtaa aaatcaaccc 796441 agtaccatgc aatatcaggc tgttccactc gttcgatcgg tatatttttc agcagctgat 796501 gctctgttgt gattgcggta atgttgatca taaacaaccc tccacctgcc attatatcat 796561 gcggtcttta tgagaaaagt atacggtact ctctgcctaa ttccagcggc atgttatact 796621 gaacaaaaac ggaaaaaagg gtggatctca tgtggaagga aaaagtatct gtcacgcctc 796681 cgtatcattt tgaccgcgtg ctggacaggc tgtctttaga ccccctcaat gctgttgatc 796741 gagaggcgag ggaagtccgt gtgccaatca gaaatcaagc gggggacgta tgtattgtaa 796801 aggtacaggc gttaggccat gcgggcgagc ctgagttcct cgtcagcggg gaaacggatc 796861 agggagaaat gatgaaggaa atcaagcgga tttttcaatg ggaaaatcat ttgcagcacg 796921 ttctggatca tttttcaaaa acgagcctgt ccgccatttt tgaagagcat gccgggacgc 796981 cgcttgttct ggactacagc gtgtacaact gcatgatgaa atgcattatc caccagcagc 797041 ttaatctttc cttcgcttac acgctaacag aacggtttgt tcatgcgttt ggcgagcaga 797101 aggatggcgt gtggtgctat ccaaagccgg aaacgattgc ggaactcgat tatcaggatc 797161 tgcgtgatct gcaattcagc atgagaaaag cggaatacac cattgataca tcaaggatga 797221 tcgcagaagg cacactcagc ttgtcagagc tgccgcatat ggcggatgaa gacattatga 797281 agaaactgat caaaatcagg ggtatcggcc cgtggaccgt gcaaaacgtc ctcatgttcg 797341 gacttggccg tcccaattta ttcccgcttg ccgatatcgg cctccagaat gccatcaaac 797401 gccactttca gctggacgat aagccggcaa aggatgtcat gctggcgatg agcaaggagt 797461 gggagcctta tttaagctat gcgtctttgt atttgtggag gagtatagaa taattcgtct 797521 gacaatgaag gaaatcctgc aaacgtgtta tactagaaag atgtgaaaaa accatttcac 797581 tttctgccat ccgcagaaag cttcatatag aaacggagag aacaacgtga accaacaaaa 797641 gaaacaggcg cccgtcgaac tgaaggtcgg acaaactttt ccgctgacga ttaagcgtct 797701 cggcattaac ggagaaggtg ttggctattt taagaaaaaa gtcgtcttcg tgcccggcgc 797761 gcttcctggc gaagaagttg ttgtgcaggc cacaaaggtc cagccgaagt tttcggaggg 797821 ccgcattaag aaaatccgca aggcatctga gcaccgggtg gcaccgcctt gccctgttta 797881 tgaacaatgc ggcggctgtc agcttcagca ccttgcatac agccagcagc ttcgggaaaa 797941 acgtgatatc gtcattcagt ctcttgaacg ccatacgaag tttaaagttg aaaacatgga 798001 aatcaaagaa acgattggca tggacaaccc gtggaattac cgcaataaaa gccaattcca 798061 gatcgggcgc tcgcaaagcg gcagcatcat cgccggctta tacggccttg attctcatga 798121 tatcgtgccg attaaagact gtatcgttca gcatccggca acgaacaaaa caacaggcat 798181 cgtccgccgc attttagagg acttcaatgt gtctgtttat aatgaaagaa aacgaaaagg 798241 cgacgttcgc acgatcgtga cgagagtcgg ctttgaaaca ggcgaagtgc aggtcgtgct 798301 tgtaaccgca aaagaaacgc ttccgcacaa ggaagaaatc gtcaaagcga ttcaaaagcg 798361 attgccagag gtcaaatcca ttattcagaa tgtaaacggg gcgaaaacct cagtgatttt 798421 tggtgagaaa acaaaacagc tcgccggaaa aacagtgatt caagaagtgc tcggcgacgt 798481 atcttttgaa ttgagcgccc gcgctttctt ccagctcaat ccggaacaga ccgtcaagct 798541 gtatgatgaa gtgaaaaaag cggcgcagct gaccggaaaa gaaaaagtcg ttgatgcgta 798601 ttgcggcgtc ggcactatcg gcatgtgggt tgcggacgga gcgaaggaag tccgcggcat 798661 ggacgtcatc aaggaatcaa ttgacgatgc taagaaaaac gccaaaaaac acggcatggc 798721 aaatgccaca tacgtaacag gaacagccga gcactggctc ccgaaatgga cgaaagaagg 798781 cttccgcccg gacgtcgtca ttgtagaccc gccaagaacg ggctgtgaca gcacgttctt 798841 ggacacgatc aaaaaagtca aaccgaaacg ctttgtctac gtttcctgca atccatccac 798901 gcttgcgaaa gatttgcaga cgctgtcgaa ggactatcgc gtggactata ttcagcctgt 798961 cgatatgttt ccgcagacgg cgcatgttga agcagtggcg aggcttgtat taaaatcgtc 799021 taactaaaaa gaacatttcc cagtcataaa atagttttcc taataagacc tggatttcgg 799081 taaaataaac aattccgatt tccgggtctt tttcgtgcgc agctcttgtc ctaacggtct 799141 gttctcaatt ttatcttcct tcttttcgcg gagatcttta ttttaactgg cgaaaagaat 799201 tgaaaaaacg tgttgaaaag caggtgaaaa aaagcgttat ttaaccggaa aaatatcctc 799261 ccagtatgtt taaaatacat gagtagaatg atgtaaaatc atagatgtat tttcataatt 799321 tgtaaaatta tatattgact tgcagttatt acgtgtgaaa tattgatgat aggaatataa 799381 ggaaagtatg gcgtatatca tttcaagagt cattcgatgt aaaaagttga aacattgtaa 799441 taaatgaaag aggtgaaaat gatggccaac cccattttaa aatgcataac gtatgagcac 799501 tacaacaatt aaataatagt gccgagacga taacaactat tacagtaata cctacaatgg 799561 ttatatcctt gcgacaatca tgcttcataa tataatgatt ttagattgac acttggctaa 799621 aaagtattgc agagaaggaa atggataatt aaatggataa agtatataaa agaagttggt 799681 ttcaaacatt tttggcattt ttagtatctc agctttattt taattttgta gaattaacgg 799741 gatggggtcc taagtataga gaaatgaatg gattcccagc aaacatagtt gaactagatt 799801 tctttcaaac atatctttca ttctatgata atccatggtt taatattatt actgttttct 799861 tgggagtttt cactattata caaataatta cagggataac aaaggatatt cgaaattaaa 799921 gcaataactt ctgatgcctt atttaatgat gaaagaaaat gtacactttc ttaattatct 799981 tatgagtgaa gactgcgaca cttagtcagc agtctatttt atggttctgg atcaggatta 800041 ccgaattata accctataca aatatatagt aggttgccac ttgctgcgtt ggttattttc 800101 taaatcatga gcaaatccca aatgattcag attgaagttc ttgaattctt ttaaataagg 800161 gtttattttc tcttctcatc ctctttactc catgtgattc acaagtggta gcagcttaag 800221 taggtttttt cattctcttg agtactcagt tataccaccc ccaactcaat ttgctttatc 800281 tctattagtt tttccgcaaa tatgatatag agatacggat atggtgtagt gttaaatatc 800341 ttatcttcaa taacagggca attattttgc gttggtaata tggagaactc atatgatatt 800401 ctatttaggt tggaatcctt tttatccaaa aagttcaaaa gcaaggccac taagaaagac 800461 gaaggtcagc gccagttaac cagaatataa aaaatagggt agataatcat cccacgtgaa 800521 atcttcaaaa tttactatag attgataaga aatgctttcg catgcgataa gtgtaaaaga 800581 agcatggtca gtttttaatt tgggataaag gttcagccgt atcccataat gaaaggattt 800641 gatttttgtt atgacagaaa atttctggcg tgaattacca cggccgtttt ttgtactggc 800701 accaatggaa gatgtgacag atgttgtttt ccggcatgta gtaagtgaag caggcagacc 800761 ggatgtgttt tttacagagt tcacaaactc agagagctat tgccacccgg atgggaagga 800821 tagcgtgcgc ggccgtttga cttttacaga ggatgaacag ccaattgtgg cccatatatg 800881 gggagataag cctgaaaact tccgtaaaat gagtattggc atggcagagt taggatttaa 800941 aggactagat atcaatatgg gctgccctgt gcctaatgtg gcggggaatg gaaagggaag 801001 cggccttatt tgccgtcctg cagttgcggc agaattaata caagctgcaa aagcaggggg 801061 attgcctgta agcgtgaaga caagacttgg atacacggat gtggatgaat ggcgcgagtg 801121 gctgacacac attttgaaac aggatattgc gaatctttct attcatctgc gtacaagggc 801181 agaaatgagc aaagtagatg cgcattggga gctcatccca gagattaaga aacttcgtga 801241 cgaggtggca ccagatacat tgctaacaat aaacggggat attcctgacc gtcaaactgg 801301 cttgaaactt gctgaacaat acggcgtcga tggaattatg atagggcgcg gtatttttac 801361 aaatcctttc gcttttgaaa aggagccgaa agagcatagc agcaaggaat tgcttgatct 801421 cttaaggctg catctggatc tccatgatga atattcaaaa gaagaagccc gtccatacaa 801481 gcctcttcct cgctttttca agatttatct ccgcggattc cgaggggcaa gtgaattaag 801541 aaatcaatgc atgaacacaa agtcaacaga tgaagtgcgt gcattgctcg acgactttga 801601 gagaaagtat cttgatggga tagagtaaca gcagtgcttg attcaaaaaa ggctaacaaa 801661 ataaagggat ttttacacaa ttcttgacta aaataaacct ggattttcgg taaatccggg 801721 tcttttttgt acgcagcttt tactcagcct gtcttttctc taatttattg taagaaaata 801781 atggtatatt tagtggagat atcatataaa gggggagagg aaaatgaaac ggctatgcat 801841 catcccctgc ggcaagaaaa aaatctggga tgtccagcct gatgccgggc cggtaagagc 801901 agaggacgct tatctcagcc cgtttcatca ggcgtgcgag cggtatgcaa aaacattttt 801961 cgatgagtgg gtgattttgt cggcgaagca cgggttcctc cgccctgatg atctcgtttc 802021 gggaaattac gatgtcactt ttggcaccgg tcatccggaa atcatgacag cggacgagct 802081 gcgccgtcaa tttcacgaaa aaggcttttc tgatatcgaa gagctagtca tgcttggcgg 802141 aaaaaaatat cgaagcgttc taaacgccgt catcggagaa caccagcata tcagctggcc 802201 gctatcatca tacaaaggca taggctatat gctccaagcg ctgaaccggg ctgttgaaga 802261 aaagcatgaa ctgtagcacg tacatatgag gaaaagagtg ggaacatgaa aaaacttgtg 802321 tttggcttgc ttgccattgt gttattcgga tgcggactat atatctatca tgtatggttc 802381 ggtgatccat tttcgaaaaa tgctgcagaa cagaagctag tgtcttatgt gaaacaaacc 802441 tatcctaaga aagaaatcaa gatcacgaat ggggtatata acgctaaaac gtctgaatat 802501 gtatttgaag caacctccca atctcatcgc tacccaatgt gtacgaaggg atttctgcat 802561 cctaaagtaa cgtgcgatgg aattgaagaa gcgtataccg aatcagtagc aaaacatgta 802621 aatgaagaag caacgaaggc aatcgaagca gatctgaaaa aagcggttcc tcgatttata 802681 aaagctgatg ctgctttgag tatcgaaaac ggacagttca cgttagatac aaaatggaac 802741 aaaaagctgg ctgaaaaagc gcctatgagc atgacgattc agttagacgc cagcgggtta 802801 tcaaaaacag atgccgcaaa gatggcggaa acggtcagaa aaacgcttaa tgaaaaggga 802861 tatacatact caaacggcac gatagactgt atgcagaagg acggggacgg cggtattgga 802921 tatgtcaaat attcaattga ttttctttca aaagcagcta ttcagtcaaa cgatgcagag 802981 gaactaggaa gttaaaaaga tttccaagga aataaatacg tcgatcattg tcaaaggccg 803041 ggtgatatcc ggtctttttt ttgcatgctg taaaacgaga caaatgaatc agtttgagac 803101 aaaacgagac acacgtctca aactgtctcc aaagtgaaga tgagaagact gattttacgg 803161 gctcaaaaga ctggcacact tcttgcattt ataatggtga accctaaata gaaggaggcg 803221 cacaaaatga aattgttaaa acgagaaggc ttgtcattaa ctgaggaaaa agcgctgtgg 803281 atgtaccaaa agatgctgga gatcaggggc tttgaagaca aagtgcatga actgttcgcc 803341 cagggagtgc ttcccggatt cgttcattta tatgccggtg aggaagccgt ggctgtaggg 803401 gtgtgcgctc atttacatga tggcgacagc attacaagca cccacagggg acatggacat 803461 tgtatcgcca aaggctgtga cctggacggc atgatggcgg aaattttcgg gaaagcgacc 803521 ggattgtgca aaggcaaggg cggttctatg cacattgcgg atcttgataa aggcatgtta 803581 ggcgcaaatg gaatcgtcgg gggcggcttt acgctcgcat gcggatcagc gctcacggct 803641 aaatataaac agactaaaaa tgtaagcgtt tgctttttcg gggacggggc aaataaccaa 803701 ggtaccttcc acgaagggct gaatttagcg gctgtatgga accttcctgt cgtatttgtt 803761 gctgaaaaca acggctatgg cgaagctacc ccatttgagt acgcatcagc ctgtgattca 803821 atcgccgatc gggcggctgc ttataacatg ccgggggtta cagttgacgg caaagatatt 803881 ttagcagttt accaggcagc cgaggaagcg atagaaagag caagaaacgg cggcggcccg 803941 tctttgattg aatgtatgac ctacagaaac tacggccatt tcgaaggaga tgcccaaacc 804001 tataaaacga aggatgaaag agttgagcac cttgaagaaa aagatgccat tcaaggtttt 804061 aaaaactacc ttttaaaaga aacagatgct aataagctgt cagacattga acagcgtgtc 804121 agcgaatcga ttgaaaaagc cgtctcgttc agcgaagaca gcccatatcc aaaagattcg 804181 gagctgctga cagatgtgta tgtgtcatat gaaaaaggag gaatgtaaga gatggcgaga 804241 gtcataagca tgtcagacgc gatcaatgaa gcaatgaagc ttgcgatgag aaaagacgaa 804301 aatgtgcttt tgatcggtga ggatgtcgcc gggggagcgg cggtcgatca tttgcaggat 804361 gatgaagcat ggggcggtgt attaggggtc acaaagggac tcgtacagga attcgggcgt 804421 acaagagtgc tggacactcc gatttctgag gcaggctata tgggagcggc tatggctgcg 804481 gcatcaaccg gtttgagacc gattgccgag ctgatgttta acgattttat cggcacgtgc 804541 tttgatcagg tgatcaacca aggggcgaaa ttccgttata tgttcggcgg aaaagcgcaa 804601 gtgccgatta ccgtccgcac cacatacgga gcagggttcc gggccgctgc ccagcattca 804661 caatcgctgt atggcctttt cacgagcatc cctggactga agacagttgt tccatccaat 804721 ccgtatgatg ccaaaggtct tttgcttgca gcaatagaag ataatgatcc ggtgtttttc 804781 tttgaagaca aaacgtccta caacatgaag ggcgaggtgc cggaagatta ttatacaatt 804841 cccctcggaa aagcggatat caaacgcgaa ggcaatgatg ttacgctctt tgcagtcggc 804901 aagcaggtca atactgcgct tgaagcggct gcacagcttt cagagagggg catcgaagcc 804961 gaggtccttg atccccgcag tctgtctcct ctggatgagg atgcgatttt cacatcgtta 805021 gaaaaaacaa accggctgat catcattgat gaagccaatc cgcgatgcag cattgccacg 805081 gatattgctg cgcttgtcgc tgacaagggc tttgatttgc ttgatgcgcc gattaaacgg 805141 attacagcgc cgcatacacc ggttccgttt tcaccagtgc ttgaagatca atatttgccg 805201 acaccagata aaattgtcag cgtcacgctt gaattgcttg gcgagccggc attgaattaa 805261 aggggggaca caaatggcgg taaaagtagt gatgccaaaa ttgggaatgg ccatgaaaca 805321 aggggaagta tcgatatgga ataaaaaagt aggcgacccg gttgaaaagg gagaaagcat 805381 tgccagcatt caatcggaga aaattgaaat ggagatcgaa gcgcctgaaa aaggaacgct 805441 gatcgatatc aaagtgaaag agggagaaga ggttccgccc ggcacagcta tctgctatat 805501 cggggacgcc aatgagtcgg tgcaggaaga ggcgggggcg cctgttgctg aagacaatat 805561 gccgcaagcc gtccagcccg tcaaacaaga aaacaaaccc gcagcctcca aaaaagatcg 805621 aatgaaaata tctccagtcg ccaggaaaat agcagaaaaa gcaggattag acctaaaaca 805681 actgaaagga actggaccag gcggacgaat cgtgaaggat gacgtaacaa aggctcttgc 805741 tgaacagaaa aaagatcaag caaagcctgt ttcggagcag aaagcgcagg aaatcccggt 805801 gacaggcatg agaaaggtca tcgctgcccg aatgcaggaa agcctggcaa acagcgcgca 805861 gctgacgatc acgatgaaag ctgatatcac caagcttgcc actcttcaaa aacagctttc 805921 accaactgcg gaagagagat acggcacaaa actgacgatc actcattttg tctcaagagc 805981 cgccgttctc gctctgcaag ctcaccctgt gctgaacagc ttttatcaaa atgagcgcat 806041 catcacacat ccccatgtgc accttggtat ggctgtagcc ttggaaaatg gcttagtggt 806101 gcctgtcatc cgccatgctg aaaagctatc gctgattgaa ctggctcaat ccatctcaga 806161 aaatgccaaa aaagcacgcg agggacgtgc gggaagcgaa gaactgcaag gatctacttt 806221 ctccattaca aaccttggcg cgtttggagt tgagcatttc acaccgatac taaatccgcc 806281 ggaaacaggc attctcggca tcggagcaag ctatgacaca ccggtgtatc aaggggagga 806341 gatcgtcaga agcacgatcc tgccactcag cctgacattt gatcacagag cgtgtgacgg 806401 cgcccctgcc gctgcattcc tgaaggcgat gaaaacatat ttggaagaac ccgcagcatt 806461 aattttatag gaaaagcagg tgaaaacgac atgacattag ccattatcgg cggcggacct 806521 gcaggctatg cggctgcggt ttccgcggca cagcagggca gaaacgtgct gctcattgac 806581 aaaggcaagc ttggggggac ctgcctgaat gaaggctgca tcccgacaaa gtctttgtta 806641 gaaagcgcaa acgttcttga taaaatcaag catgccgaca gctttggaat cgaacttccg 806701 gcaggtgcga tatcagtcga ttggagtaaa atgcaaagcc gaaaacaaca ggttgtcagt 806761 cagcttgtcc aaggcgttca gtacctaatg aagaaaaatc aaatacaggt tgtaaaggga 806821 acagcctcct ttctttctga aagaaagctc ttgatcgaag gagaaaacgg aaaagaaatc 806881 agagaggcgg accaagtatt gattgcctcc gggtcagagc caatcgagct gccttttgcc 806941 ccatttgacg gcgaatggat cctcgacagc aaagacgcgc tttctctttc cgagattccg 807001 tcttcactag tcattgtcgg cggcggtgtc atcgggtgtg agtatgcagg gctgttcgcc 807061 agattgggat cgcaggtgac catcattgaa acagcggacc ggctgatccc ggctgaagat 807121 gaagatattg cccgtctctt tcaggagaaa cttgaggaag acggtgtcga agtgcatact 807181 tcatccagat tagggcgggt ggatcaaacg gccaaaacgg caatatggaa aagcggtcag 807241 cgagagttta aaacgaaggc cgattatgtg ctggtggcga tcggcagaaa accccgtctt 807301 gacggattgc agctggaaca ggccggagtt gatttttctc caaagggcat tccggtgaat 807361 gggcacatgc agacgaacgt gcctcatatt tacgcgtgcg gagatgctat agggggcatt 807421 cagctcgcgc atgccgcttt ccatgagggc atcatcgctg cttctcatgc ttccggaagg 807481 gatgtcaaaa tcaatgagaa acatgtgccg cgctgcatct atacgtcccc ggaaatcgcg 807541 tgtatcggaa tgacagaacg acaggcaaga agcatatacg gggatgtgaa gatcggcgaa 807601 ttttcatttt ccgcaaacgg caaggcgctc attaaacagc aagcggaagg aaaggtcaaa 807661 atcatggctg aaccggaatt cggcgaaatc gtgggtgtct cgatgattgg cccggatgta 807721 accgagctca tcggccaagc ggcagcgatc atgaatggtg agatgacggc agatatggcg 807781 gagcatttta tcgccgccca tccgacttta tcggaaacat tgcatgaggc gctgttaagc 807841 acgatcggcc ttgcggtaca tgcataataa aggaaaaagc aggcgcatgg atataaggcg 807901 cctgcttttt tattgttgaa agcgctttat ttttccccta caatagatga aaacggcgtg 807961 taagggagga gcgatcaagg aaatgaattc ggtcccaaac gatttgcaaa cctggaaacg 808021 ttttgtgaaa gacggtgtgc ttgacgaagc ccgattaaga aaacggattg cagagtcatg 808081 gcatcgctgc aaaaaagctg aggtcaatcc ttatttagaa aaaggcccga aggttttaca 808141 gcaaacggag ctggatcagc agtcaaaaaa acattcattc ttcttgacga ccgcaaagcc 808201 ttacctcgaa aaactgctgc ctgccataaa agaaatggaa atgatggcgc tgttaattga 808261 ttcagacggt gttgttctgg cattggacgg ccatccgcgc gcgctctatg aagccaaacg 808321 catcaatttc gtcgaagggg catgctggac agaaacggct gtcggaacaa atgcgattgg 808381 cacggcgctc cacatcagcg agccggttgc aatacaagga tcagagcatt actctatcgc 808441 ttcccatctt tggaactgtt cagctgctcc gattcaccat gaggatggca gccttgcggg 808501 tgtaattgac atatcatgcc cggcggcagg cgcgcatcct catatgcttg gtattgccac 808561 ggcgattgcc tatgccgctg aacgggaact cgcagctaaa agccgtgaga aagagctgga 808621 gctgatcagc cgttttgggg agagagctgc atccagtgtg ccgatggtgc tctgtaatac 808681 caagcagcac atcatcagtg cgagcatgcc gattcgaacc tcaatgccgg attggcaggg 808741 ccggcacctg tacgagttga aggaacgggg ctattcaatc gaaaatgctg tcaccatagg 808801 agatggcggc acttgttttt atctttcgga acaaaagaaa aagaaggcgt ttcgattcaa 808861 tggagtgatc gggcaaagcg gccgatcgca agcgatgctg atgcaccttg aacgagcagc 808921 tgcgacggat gcatcggtct gtttgtcggg tgaaacgggt acggggaagg aggtcgcggc 808981 tcgcgcgctt catgagaaca gtgagagacg gcacggtccg tttgttgctg tcaattgcgg 809041 agcgattccg tctgatttga ttgaaagcga actgttcgga tatgcagagg gcgcttttac 809101 gggagcgaaa cgaaatggct ataaaggcgc ctttcaaaaa gcgaatcaag gcacattatt 809161 tttagatgaa atcggagaaa tttcccactc gatgcaggtt gcacttttac gggtgcttca 809221 ggaacgcaag ataacgccaa tcggcgggac gaaagaaatt ccggttgata tcagagttat 809281 tgccgccaca cattgtgatt tacgcgagct tgccgaaaac ggaaaaatca gagaggactt 809341 gttttaccgt cttcatgtct atccaattga actccctcca ttacgcgatc gcaccgagga 809401 tatcccggat ctctttgagt actacaaaca gaagaatcat tggccaggcg atcttccttc 809461 tgatttttgt aatgtgctga agcaatggaa gtggccgggg aatatccgcg agctgtttaa 809521 tgtgtttgaa cgtctttcta tcagatttcc ggacggccgg ctgagagatg aatcgcttcc 809581 cgctttactg gaagccgctg gattgccggc cagctctgca gaaaaaaagc cggctgctgc 809641 cggcgtgctt acttttcgtg agcaaatcca aaaggatatg atgatcaaag cgcttgaatc 809701 tgcaaaagga aacgtctctc aagccgcaaa aatcagcggg atcccccgaa gcactttcta 809761 caaacgcctg aaaaaattca acttgtccgc tgaatcataa agcatacttc cttcaggaaa 809821 tggaaacgtt atgtattgaa ggagggtgtt acgatgaata ttcaaagggc gaaagaaatt 809881 gtagaatctc ccgacatgaa gaaagtaaca tataacggcg ttcctattta cattcagcac 809941 gtaaatgaag aaactggaac agcaagaatt tatccgcttg acgaaccgca agaggagcat 810001 gaagtgcagc tgaacagctt aaaagaggat taaacaaaaa tggcccgctt cataagcagg 810061 ccattttgtt atccgcgcgg cgcaaataaa ataacacaga caccgatgag acaaatgaat 810121 gcgccgatcc agtcatacag atcaggtgtt ttccggtcaa caagccatcc ccacaggacc 810181 gcaagcacga tgaatactcc gccataagcg gcgtatacac ggccgaaaga tgggaaggac 810241 tgaaacgtcg gaagaatgcc gtatacaatg aggatcagcg ccccggcgat tccgtagcca 810301 gctggctttg cctctctcag ccatagccaa accagatatc cgccgccaat ttcagcaagc 810361 cctgccgcga gaaataaaag aatggtaatc agcatcatga gcactcctca atttgcattt 810421 atctttcatt atagaggagg agagctttta aagcttcgga tgattctcaa attccttcaa 810481 atacgctttt cgctgaacct ctgtaaattg gctgatccaa ttgttttgag cctcttcatt 810541 caaatgggga aggatatagc gttcaaccgc ttcgaaaaac agcggattcg tgatgatgtt 810601 ccaggtcggg attcgaacga ttttgccgtc tgttttctcg atgataatat cctcaaaaaa 810661 gatccctttc aaactgtatt gatggcgtcc catataaagc cgcttcacct cggaaaacag 810721 cacgctgcgc tttctcaaga agatttcgcc actaggtccg gtctttatgg tgaaaatgac 810781 atttccacgg cttgtgaacg caggaaaagc cataaagaat gtgatcaatc cataaatcat 810841 cgccagtaat ccgccgccca aataaagcag ggcatattta gattcaaacg tgagggcttc 810901 agacaccagc cagactccca caataaaggc gccccctgta gcgaggaaca gccaagccct 810961 tagaaacatc atgcttttta cttcaatcat gtgctgcccc taaagcttcg gatgattctc 811021 aaattccttc aaatacgcac tgcgttggat gtctgtaaac tgtccgatcc aattgctttt 811081 cgcctcttca ttcagatgtg gaaggatata gcgttcaacc gcttcgaaaa acaacggatt 811141 cggaatgatg ttccaagtgg gaatgcgaat ggtcttctga tccacggttt ggatcaatat 811201 atcttcttgg aagattcctt ttagactaaa tttatggcgg ctcatctcaa ttttcttgat 811261 atcagtaaac gtaacagaca ctttgtcagt gaacacttct ccattttttc ctgtcttgat 811321 gcggaaaatg gtatttcccc gcggggtgaa agccggaaag aagatgataa ataaatataa 811381 acaaaacaag gtgaacagaa agccagcagg aatggctaat aggtaatatt tcgtttgaaa 811441 cgtaataccc atataaaaga gccacaaaca tgctaatccc ataccggcag atccgacaaa 811501 agcccatatt ctcaggaaca ttttgctttt gacttcaatg atttcttggt ttttcaatgc 811561 ttttctcctt ttgttaattc aattcttatc attttgaaat gatttgattt acaacatcct 811621 tatgagcagg gaggatagaa aattcattct gggtgatgcc tgtgacaagc caagtatggt 811681 gggcccccgg caggacgaat gccatgtcag ccacttcagg agtgttatct tttccatatg 811741 ccagacgcat aagtgtatcc attttccctt tccgcaaagc cagatcattt gcaaatcggg 811801 taacgtcctc ttggtggtca tgtttttcaa ggaactcttt tagatatgaa gggttgtctg 811861 aagcgccctc caagagtttt tcaaattcat ttgatgtcaa tgttacaatc gattctcttt 811921 tatcctctgt atctattata tgtaaaaact catctgtctt agcaagtaac ccttcacttg 811981 attccatttt tgtaatgcga tggacttgtt catcaaaaag gagttcgtga gagtaggtgc 812041 cgaattttga tacatggcat gacacattct gttcggcacc ttgcccgtta aatttagaaa 812101 gcttcactgt atagtcagcg tcgtttaata catggataaa cggacagtac tcgtccttta 812161 accgatattg atggttccga tattccgctg catccttggc taagagtgag cggcacgcgg 812221 cttcaaataa ggcgccgagc tgttcatctt ctatttccgg aaaataggcc tgcttcaagg 812281 ccattccctg ttcaaaaaac ccttcgctgt aaaagcaaaa caagagttct tctatgctaa 812341 ttgtaaactg cttcattgtt tattctccta tccaaatgaa aatttccctt taaggaaatg 812401 ggttgcgccg tgtataagcg aatccgctgt tttctttgct ttttccattc cttttttcgc 812461 gctgtctatc cctttatgta tcgatttatt cgccgcatct atgccgtcat tcactgattt 812521 gacgactttg ccggctgatt ccagcccttt tttggctgta tcaacaacag catggatcgg 812581 ttctttcagc tttaaggctg ctttttcagc aaaaccggct gtatatttgg cgatttgttc 812641 tccgacgact ccgccaatgt atgaacctgc tgccccaaga aggacagtac ccacaggtcc 812701 tgcaaagctt ccgattgcac cgccgatgac agcaccagct gtggcaccgc cggcaacaaa 812761 aatcgtatta ttcacagcat tcccgacggc cttggcgttt tcacgcttga gaacttccgg 812821 tttatcctgg tattttgcat aattttcagc aattttcacg cctgctccga atgtttcggt 812881 cgctccggta atcagtgtgg cggtaatggc atttcctttc gcgaatctca agcccgtttt 812941 tcccacatcc ttcaaagtgg agcgtacgcc ggcttcatta agaaatcctt ttgtgtagct 813001 tctgacgctg tttgaaaaat ccaccgtgtc ctgaggaaag tattttgtaa actttttatg 813061 taccaaatct gaaaatggac ggtttgtctt tttcaacaaa tatttaggat tcaaaagcac 813121 tcttgccgct ttttgataac gtgagctgtc aacggccctg gaaatatcca agagcagttt 813181 tgagtgctgg gctgtatgca agccgcttgg ttgtttcaca aatttcgtaa gccctaatcc 813241 gtaatatttt ccctgcgtca gcataagagc ggttaagctt gtcatcgtac cgtatttgtc 813301 gtaggcattg tagagctttc gcaaaatatc atcttgttcc acaaatttat cgcctgtttt 813361 tctgatgaaa atctcattgt cactcagctt agtgacgagc gcctttcctg agctccacgc 813421 atcgcccact ccagaaaaac agctgctgta gcggggatcg cattgcaaaa tcatctgccc 813481 cagctccaca tgcaggtcct tatatttgtt ttccatatca gttaattcag tgactacatc 813541 atttgcaagc tgttcgagct tatccggatc aactgcaatg tttcctgaca caccgttcac 813601 ctcccgagtt tatgtctttc ctctcttgct ttacgctcca gttcttccat tctggcaatt 813661 tcagcttttc gttcttctat tttgacagcg gcagccttca gctcttggct tgtttcaagc 813721 agctcctgtt cgaattgatc gtaggcggct ttcgtttcct cgaaatcctg gtcaaacgaa 813781 tctcttgctt tgccctgcca agcatctccc aatgcagata accgggattc aagcagcatt 813841 ttggagcttc tgacctcttc tgcggccgca ctatacttgt ttgccagctc aatgacttta 813901 tatgagtcca acttttgtcc cctgcctttt ctaaattcac gcacaattgg atgttttata 813961 taaatgatta taaataattc ggcatgtatc cgaatcgtac aaaagaacct tttcataaga 814021 attggaaggg cgtatattca cttaaaattc acagttggtg agactttaag attacaaaaa 814081 aggtaaaaaa accaaatctc tcagacataa ggcaaatgag aaatttcccg ctctatggga 814141 aaaaacacta aagttgatca aatgacctaa gtgcgccaaa cgtgttacgg gacgagctat 814201 ctcatggtat aaatggaatt gtaaacgtta tcaaggaggt cgtcatatga agaaaaaatc 814261 attctcaatc gtaatagcgg gcggagggag cactttcact ccagggatcg tactcatgct 814321 cttggaccat ttggaggagt ttccgatcag aaagctgaag ctgtatgata atgataagga 814381 gagacaggat cgaattgcag gcgcctgtga cgtttttatc agagaaaaag cgccggatat 814441 tgaatttgca gcgacgactg acccggaaga agcttttaca gatgtcgatt ttgttatggc 814501 gcacatcaga gtagggaaat acgcgatgcg cgcgcttgat gagcaaattc cgttaaagta 814561 cggagttgtc ggccaggaga cgtgcgggcc gggcgggatc gcatacggta tgcgttcgat 814621 cggcggtgtg cttgaaatat tagattacat ggaaaaatac tcgcctgatg cgtggatgct 814681 caattattcc aatccggcgg caattgtggc tgaagctacg agacgcctta gaccgaattc 814741 taaaattctc aatatctgtg atatgccggt tgggatcgaa gaccggatgg cgcaaattct 814801 tggcttatcc tcaagaaaag aaatgaaggt ccgctattac ggattgaatc atttcggctg 814861 gtggacatcg attcaggatc aagagggcaa cgatttaatg ccgaagctga aggaacatgt 814921 atcccaatac ggttatattc cgaaaacaga ggctgaagct gtggaggcaa gctggaatga 814981 cacgttcgcc aaagcgcgtg acgtgcaggc tgcagatcct gacacactgc cgaatacgta 815041 tttgcaatat tatttgttcc cagatgatat ggtgaaaaaa tcaaatccga atcatacgcg 815101 ggcgaatgaa gtcatggaag ggcgcgaagc ttttattttc agccaatgtg acatgatcac 815161 acgtgaacag tcctcggaaa acagcgaaat taaaatcgat gaccacgcat cgtatatcgt 815221 tgatcttgcc cgggcgattg cctacaacac aggtgaaaga atgctgttga ttgttgaaaa 815281 taacggtgca attgcgaact ttgacccgac tgcgatggtt gaggtgccat gcatcgtcgg 815341 ctcaaatgga cctgaaccga ttaccgttgg caccattccg caattccaga aagggctcat 815401 ggagcagcag gtatccgttg agaagctgac tgttgaagcg tgggcagaga aatcgttcca 815461 aaagctgtgg caggcgctga tcctgtcaaa aacagtgccg aacgcgcgtg tggcaagact 815521 cattcttgag gatttagtgg aggccaacaa agacttctgg cctgagcttg atcaaagccc 815581 aacccgcata tcataaatga aattccccca ttttcgaatc tgtaattgta tataatagaa 815641 agaaaatggg gggatctgat atgcagctcg aagaactgat caatcagcac tacagcaaat 815701 tgaatgacaa cgattttcat attttaaaat atatattgaa tcataagcac acatgctatc 815761 accttggaat cgacgcgctg gccaaagctt gcagtgtatc gcgttcctca attttacggc 815821 ttgcccaaaa gctcggtttc agcggttaca gtgaatttcg cgtcttttta aagtgggaag 815881 atcagccgga agaaggcgag agtatgagtt ttgaaaagct gcttgatgat attgaagcaa 815941 atttgaagtt tttacggaca aaggacatga cggacatgtg ccagctgatt gatgcagctg 816001 accgcatttt cgtctacggt tctggaaatg cgcaaaagat atgcgcccgc gacctgcaaa 816061 gaatgtttat tccgcgccat cgctatctta ttttgattga agacacaaat gaatttaatt 816121 tgatgcgcga tgattttaaa gtgaacgatc tgtttatcat catttctctt tccggagaaa 816181 caccggagct gattcctcag gcaagaatgc tttctgcaaa gggtattccc tttatttcca 816241 ttacgaattt aaaaaacaat gtcctcgccc agctgactcc gcataatctt tatgcgacaa 816301 gcaaacctgt gacattaagc gatagaacgg aaattgtcgc ttttgcaccg ttttttctcg 816361 ttggcgaagc attgttccgc gcatatgttg attacaaaga ggcagaaaaa aatgacaatg 816421 agtagcaggg ggttctggta tgatgcaaaa aattcagcgc tttggaagcg cgatgtttgt 816481 gcctgtttta ttattcgcgt tcgccggcat tatcgtcggt atcagcacgc tctttaaaaa 816541 taaaaccctc atgggaccgc tcgccgatcc tgacggtttt tggtatcagt gctggtatat 816601 cattgagcag ggcggctgga ctgtttttaa ccaaatgccg ctcttattcg ccattggcat 816661 cccggttgct ttggcgaaga aagctcaggc acgcgcctgt ttggaagcgc ttactgtcta 816721 cctgacattc aactattttg tcagcgcgat attgacggta tggggaggag catttggcgt 816781 cgacatgaat caagaggtcg gcggaacgag cgggttaacg atgattgcgg gcataaaaac 816841 gctcgatacc aacatcatcg gagccatctt tatttcttcg attgtcgtct ttttgcataa 816901 tcgctatttt gataaaaaac tgcccgattt tctcggcatc tttcaaggct caacatatat 816961 cgtgatgatt tccttcttta ttatgatccc aattgcgttg gctgtgtctt atatttggcc 817021 gatggttcaa tcgggaatcg gctcgcttca aagcttcctg gttgcttctg gggcggtggg 817081 cgtttggata tacacgtttt tggaacggat tttaattccg accggccttc atcactttat 817141 ttacacgccg tttatttatg gcccggctgt agcggaaggc gggatcgtca cgtattgggc 817201 acagcatctc ggcgaatatt cgcaaagcgc caaaccgctg aaggagctct ttccgcaagg 817261 cggattcgcg cttcacggca actcgaaaat cttcggtatt ccgggtatcg ccctggcttt 817321 ttatgtgaca gccaaaaagg aaaagaaaaa actcgtcgca gggctgctga ttcctgtcac 817381 actgacagcg attgtcgccg gtattacaga gccgattgag tttacgttct tattcatttc 817441 acctttctta tttgcggttc acgccgtgct tgccgccaca atgtcgacag ttatgtatat 817501 ggccggcgtc gtcggaaata tgggaggcgg actgattgag gcggtaacct tgaactggat 817561 tccgctcttt ggcagccacg gtatgacata tgtgtatcaa attttgatcg ggctctcgtt 817621 tacagcaatt tattttttcg tcttcagatt tttaatcctc aaattcaata tcgctacacc 817681 aggacgggaa aaggatgaac agcaggaaac aaagctatat tcgaaaaagg aatacagaga 817741 acgaaaaaac aaggatgaaa cggcctccgc tgctgaaacg gctgatgaca ccgcttttct 817801 gtatattgaa gcgctgggcg gaaaagacaa catcactgaa gtcacaaact gcgccacccg 817861 cctcagagtc agtgtcaagg atgaaacaaa ggttgaaccc gacagcgtat tccgcgcgct 817921 tggcgcacac ggcgttgtca ggaacgggaa ggcgtttcag gtaattatcg gattaagcgt 817981 gccgcagatg cgggagcgtg tggaaaaaat attgaatcaa taaagactgc cctccttttc 818041 gggagggttt tcgtttgccg tcaaaaagac cgccatagta aagtaaagaa agagacaatc 818101 gagtaaaaag gggtttggag gcttttacat gcaaaaggct ttgtcgtttt taaaaccata 818161 ttcattgctg gcgggaattg ctctgattct tatgctgacg gagcttgcag ttgaactgat 818221 gcagccttta ttgattgcaa aaatcatcga cgatgggata ttgaagcaag atctgcggca 818281 tgtatggata tggggcacgg tcatgatcgg gctgaccgtg ttatcctttg cggcggggat 818341 gctgaattcc ttttatgccg cccatgtcag ccaaagcttt tcctatgata cgagaaaagg 818401 gctttttcaa aaaatccagt ccttctccta ttccacattt ggacagtttt cgtcctcttc 818461 ttatattaca aggctgacaa acgacgtcac acaggttcaa aatatgattt ttatgagttt 818521 gcggtttatg ctgcgggctc ccttaatgat tgcaggcggc attgtgctgt cgcttgccgt 818581 taatgtgaaa ctcgggtttt ttctgcttgt gaccattccg atcctgatct tgtttttgct 818641 atgggtatta aggaaaggcg gggcactgtt ccgctcagtg cagaaaaggc tggatcaagt 818701 gaacaccatc atgcaggaaa atttaattgc aatcaagctg atcaaagcgc tgcttcgcgg 818761 cagccacgaa gtcaaacgat ttatcaaagc caacacaagg ctgatggaaa aaacggtttc 818821 ggcctttcag cttgtggaat tcacgatgcc tgtactgatg ctgctgatga atctctgcat 818881 ccttttgatt ttgtgggcgg ggtcctacag tattacgagc ggaagcactc aggttggcga 818941 tgttgttgcg ataattaact acgcaacacg aattacaggc gcgctttcga tgtttccgtt 819001 tttgattatg attttcaccc gggcgaaggc ttcaggggat agaatcggtg aggtgcttga 819061 aacagaaggc gacgagcggg aggaaggcac catatctgat cgtttgtcag gacggattga 819121 gtttcagcat gtatcctttc gctatcctga aatggacaga gaagcgctca ggaatgtctc 819181 attttccgca aagccaagag aaacgatcgc gattctcggt gcgacgggct cgggcaagtc 819241 cacgcttttt cagctcattc cgcggcttta tcagccggat tcaggccgca tttacataga 819301 tgaaaagccg gttcaagata ttccggctga agggctgcgc aggcaaattg gatatgtacc 819361 gcaggaagtc ctcttgtttt ccggcacaat caaagaaaac atcgcttggg gcaaagaaaa 819421 tgcttcacta gatgaaataa tggatgcggc aaaacttgcg caaattcatg aaacgatttt 819481 aaagctccca aatggatatg acactgtttt ggggcaaaga ggcgtcaacc tgtccggcgg 819541 ccaaaagcag cggatttcca ttgcgcgggc gctgattcga aaaccggcta tccttctatt 819601 agatgacagc acaagcgcgc ttgatctgca aacggaggcg aagctgcttg aagcaatcag 819661 cacataccat tgcacaactt tgatcattac acaaaaaata accacggcga tgaaagctga 819721 tcagattttg ctgcttgagg acggcgaact gattgaaaaa ggcactcaca gtgagctgct 819781 ttctgaatct cagttataca agcgcattta cgagtcacaa ttcggaaggg aggggagcga 819841 gtcatgctaa aagacatccg caagcctttc caatatccca aactgccaat tgacaaaaaa 819901 gaaggcgcga aaaagcgggc gaaagcaaag gatacaaagg gcacactgag acgaatctgg 819961 tcttacttgg ctgaaagaaa aggactgctc atacttgtca tgctaatggt tgtcatcagc 820021 gccatattcg gactccttgg tccctttgtg atcggaaagg ccatcgacca ttttatcgtc 820081 gggaaaacgg tcagcggctt gattcctgtt ttgcttcttc tgctcgctat ctatatcatt 820141 cagtccctgt cgctttggtt tcaaaactat tggatgatta cgatctcgca gggcacggtt 820201 ttcagaatga gaagcgaatt gttcacccat ctgcatgagc tgccgattcc attttttgat 820261 aaacagcggc acggcgagct gatgagccgg gtgacgaatg acatcgaaaa tgtcagttct 820321 accttaaaca cgtcagtcat tcaaattttg tcaagtgtga tcacctttgt cgggacgatt 820381 gcggtgatgc tgtacatgag cccgctcctt actttgatta cgctgaccat tattccggtg 820441 atggcagcga gcctgaaatg gatcaccaac cgaacgggaa agctgtttaa agaacagcag 820501 aaaaaccttg gtgatctgaa tgggtatatt gaggaatctg tttcaggcgc aaaggtcatc 820561 aaagcatatt cacgtgagaa gcagattact gctgaattcc tcgaaaaaaa cgctgcactc 820621 aagacgtcgg gcttttgggc gcagacgatt tccgggttta ttccgaaggt catgaactct 820681 ttgaataact taagctttac aatgattgcg gcaatcggcg gtttgtttgc gctgaaaggc 820741 tggatctcga tcggctccat cgttgtcttt gccgagtatt caagacaatt tacacgccct 820801 ttaaacgatc tggccaacca gtttaatacg atgctgtccg caatcgccgg cgctgaacgg 820861 gtgtttgacg tgcttgatga aaaagaagag cgcgaggatg aaaagaacgc cgtgcatcag 820921 cccatccaaa caggcagcat tgaattccgg gatgtgtcct tcggttacga taaagggcag 820981 cagacactga agcatttaca gtttaccgtg cctgcggggc agtccatcgc gtttgtagga 821041 ccgacggggg cggggaagac aaccgtcact aaccttctcg cccgttttta cgagcctaac 821101 gatggaaaaa ttttaatcga tggtacagat attaaaaccc ttactagagc aagcctaaga 821161 aaaaacatgg ggtttgttct tcaggattct ttcttatttc agggaacgat cagagaaaac 821221 attcgctacg gcaggcttga tgcttctgat caggaagtcg aagccgctgc aaaaacagcg 821281 aatgcccata gttttattga aaggctgcca aaagggtatg acaccgtact gacgcaaaac 821341 ggttcgggca tcagtcaagg gcagaagcag ttgatttcta tagcgagggc ggtgcttgcc 821401 gatccggttc ttctcatttt ggatgaagcg acaagcaaca ttgataccgt tacagaagtc 821461 aacattcaag aagcgctcgc ccgtttaatg gaaggaagaa caagcgtcat cattgcccac 821521 aggctgaaca ccattcaaag agcggaccag attgtggtgc taaaaaacgg tgaaatgatt 821581 gaaaaaggca gccatgacga gctgattcgg caaaaaggat tttacagtga cttatatgaa 821641 agccaatttg agaaatagac ctttgtcctg cacagaggtc tttttttgtt acagttttat 821701 agtactttta tttcattttc gtaaaatgta acaaaattac ttgacgtaaa caagttatgt 821761 atatatacta gcttacatta agtaagtgat aacatttatc aaggaggata aaatgaataa 821821 atcatttgaa attggcacat tacttttaag agttattaca ggtattatct tttttgttca 821881 cggtttatca aagtttcagg gaatggaggg caccatccaa tttttcggca gcataggcct 821941 tccaagcttt atggcgtatg tcatcgcagc gattgaactg attggcggag tgcttgtctt 822001 cttcggattg gctacacgta ttgtcggtgt actgttcgct cttacactga tcggcgccat 822061 catcactgtt aagctgaaag cgccattcat gggcaatgca gaatttgatt accttctgct 822121 tttgacatcc attcacctgg cgcttactgg aagtcgattc ctggcgctgg acccatttgt 822181 gtttaaagga aaaaagaacg gaaacgtttc agcataagaa aagaggcatg cagcatgacc 822241 agcattcatg aggatacaca cattggctat gccaaactca caattcgcag tctggagcgt 822301 tcgcttcagt tctactgtaa cgtcatcggt tttcaagtct taaaaaagac ggaccgccaa 822361 gcggaattaa cggctgacgg gaaacgcgta ctgcttattc ttgaagaaaa tccgagcgct 822421 gtcgtcttgc ctgaacggtc tgtgacaggc ctttatcact ttgcgattct tcttccggac 822481 aggaaagaac ttgggatcgc gctcgcccgc ctgattgaac acggcattgc tatcggacat 822541 ggagaccatg ctgtcagcga agcgctctac ctgtctgatc ctgacggaaa cggcattgaa 822601 atgtacgctg accgcccccg cagcacgtgg cagcgtgatc gggaaggaaa ctacgtcatg 822661 acgacaaccg ctgttgacat tgagggcctt ctggaagagg caggagatga gcggaaaaca 822721 tcgcttccga acgatacaat catcggacac attcatctgc atgtcagtga tttgaaagaa 822781 gcaaaggcgt tttatacaga tgtactgggc tttgacattg tcggaaacta tgcgggcatg 822841 tccgccctct tcgtttcagc cggggggtac caccatcata tcggcttaaa catttgggcg 822901 ggaagaaatg cgccgcctaa accgacaaat gccagcggac tagattatta tactgttgtc 822961 ctgccccacc aagaggagct ggatttggtg gcaaaccgag tcaaacatgc cgggtattcg 823021 attgaagaga cggaaaacag ctttcgtgtg aaagaccctg tttccggcgc ctatattaca 823081 tttgtgattt aactgcaatc cccttgccga aataacggca gggggatttt ttatttttgt 823141 ccgccttgtt atgatgagag aaccaacttg ttaggaggcg tttacatgga actcaaccac 823201 cttgtgacgg gcaaaatagc attaaatcaa tatgtgcatc gcttagagca aaaggatgtt 823261 tcattttacg tccactactg gggagcgatg acgaaccact ataacacact gcttcataag 823321 cattcctttt atgaaatttg ttacgtggta agaggtgaag gatattacct tgaaggcgat 823381 cgtacatatc cgcttcgtga acagacgatt tttttgtcaa agccggagca tttgcaccaa 823441 atcaaaagtg aaacagggct gttccttttt tacgtcgctt tcgagctgag cgaggatcag 823501 tcaagcgccg aatggatcaa agtgatggaa gaagtgaaac aaagcccctt tatcacaatg 823561 caattgaaag atggcgaacc gccgggcctg ctttggaaaa cgttaatgct gcaagcagcg 823621 caacctgtca atgcttttga caaagagatc ctatctcatt tgtcgcatgc attgatcctg 823681 tcattaatcc aaacctttct cccgtacgcc caacgcccga aacaaaagca gcccattcac 823741 acatcttctg ctttgctgac agaggtgaaa ctgcacataa aagacaatct gtcacagccg 823801 ttaaagctga cggatgtcgc tagccacttt catatctcag ggaggcattt atcacgttta 823861 tttgcagcag aactgggcgt cagctactca gaatttgtcc aaaatgaaaa aataaacaaa 823921 gctgccgaac tgctgaaatc aacgaatttg tcgattaaag aaatagcgga agaaatcggt 823981 ttctcagtac attatttcac tcgcgtcttt tccgctaaaa tcggcagctc tccagggctt 824041 ttccgctccc tttataaaga ctcaaaaatg accgcatttc aaatcaataa accttttcaa 824101 aaaatcgaac aggccaagcc gcacgaataa gatgtcctga aatgacaaaa caatgtcttc 824161 atatgataaa gacgcgagaa atctcgttgt cttataatct ttttagaaag cggttacaac 824221 aaggggtatt gctgaaggag ggatgcattg gcttatgctt ggtgtcgggt gctctgccat 824281 tcttgaaaga aggggaagaa agccgtgagt acaaaaaaga aagaggctgt aataggaaaa 824341 gaaagcttag ctcataaagg gcttttacga acgattacat tggtatctac attcggcggc 824401 ctgttgttcg gttatgatac gggtgtcatt aatggggcac ttccttttat ggcaactgca 824461 ggtcagctga atcttacacc tgttacagaa ggactggttg cgagttccct gcttctcggg 824521 gcagccttcg gggcgatgtt tggaggacgt ctgtccgatc ggcacggccg ccgaaaaacg 824581 atcctttatt tagccttact cttcatcgca gccacacttg gctgtacctt ttcaccaaac 824641 gcgtccgtga tgattgcctt tcgttttctg cttggactgg cggttggctg cgcttctgta 824701 acggttccaa cctttttagc ggaaatttcg ccggcagaac gcaggggacg aatcgtgaca 824761 caaaatgaac tgatgatcgt aattggccag cttctggcat acacctttaa cgccattatt 824821 ggcagcacaa tgggggagag cgcaaatgta tggcggtata tgctggtcat cgcgacactt 824881 ccggctgttg tgttatggtt cggaatgctc atcgtgcctg aaagcccgcg ctggctggca 824941 gctaaaggca gaatgggtga cgccctgcgg gtgcttcggc aaatccgtga agacagtcag 825001 gcacagcagg aaataaaaga aatcaaacat gcgattgagg gcacagcaaa aaaggccggc 825061 tttcatgatt ttcaagagcc gtggataagg cgcattctat tcattgggat tggaatcgcc 825121 atcgtacagc aaattaccgg tgtcaattcg attatgtact atgggacaga aattctgaga 825181 gaagccggtt ttcaaacaga agctgcatta atcggcaata ttgcaaacgg tgttatttca 825241 gttattgcgg tcatttttgg gatatggctt ctcggcaaag tccgtcgccg gcccatgctg 825301 atcatcggac agattggcac gatgacagcc cttctgctga tcgggatttt atccattgtc 825361 cttgaaggaa cacccgccct gccgtatgtt gtgctgagtt tgaccatttt gtttcttgcg 825421 tttcagcaga ctgccatttc tacggtgacg tggctgatgc tctcggaaat ctttcctatg 825481 catgtgcggg ggcttggcat ggggatcagc accttctgct tgtggacagc taactttctc 825541 attggattca cctttcccat tttgctcaat catattggga tgtcggcgac attttttatc 825601 tttgtcgcta tgaatatcct agcgattcta tttgtgaaaa aatatgtgcc tgagacaaaa 825661 gggcggtcac ttgaacagct tgagcattcc tttcgccagt atggccgccg cgctgatcag 825721 gaaatccaaa atcaaacaac tcacttatcg taacctgaga taccaggagg aatctatcaa 825781 tgaaactatc ttatgtaaca gacagcctag ggcatttgcc ttttgaagac atgctcaatt 825841 ttgccgcaaa gcttgggatc gatacacttg aaatgacaac cgggggctgg tcgccggcac 825901 ctcacttgaa tcttgatgaa ttgctgcaaa gcagcgaaaa aagaaaagaa ttttcacaag 825961 cgctggaaaa gcggaacatg acactttgcg cattaaactg ctcggggaac cctttagatc 826021 cgggtgaatt gggcaaatcg cacagagaca taactgacaa aacgatggag ctggctggat 826081 tattaggcgt caaaaaagtg atcatgatga gcggtttgcc agccggcggc ccggacgaca 826141 aagtgccgaa ctggatcaca tacacagtaa gctggcctcc cgttttaaaa gatatcctca 826201 actatcaatg ggaagacgtt gcgatcccat attggaagaa gcttgtcaaa aaagcggagg 826261 cctgcggcgt ggggaaaata gcgcttgaga acttcagctc tcaattagtc tataatcctg 826321 agactctctt tcggctcaga aatgcagtcg gcccgatggt cggtttgaat cttgacccga 826381 gccatttgtt atggatgggc gcagacccga tcatcgcagc aagggagctc ggctcagcca 826441 ttcaccatgt ccatgggaaa gatgtcagaa ttgaaagata tttatcggcg gtcaacggac 826501 ttttagaaac aaaagaagtg acagatcctg caaaccgggc gtggaattac gtagctgtcg 826561 gctgtggaca ggatttacag tggtggaagg aatttttttc agttgtaaaa atgatgggat 826621 atgaaggtga ggtttcttta gaaatggagg atctgacgat gtcacctgaa gcgggcatcc 826681 gtacttctgt agaagcttta aaacaaacca tcagccaata ggaggttttc atgatgctaa 826741 atggagaaag aatcatctct aagccgcttc gctgggcaat ggtaggcggc gggcggctca 826801 gccaggttgg atataaacat cgtattggag cgctgagaga caatactgct tttcaattaa 826861 ctgctggcgc ttttgatatc gatgccgaaa gaggaaaaga tttcggggtg aaccttggag 826921 tggatgcgga acgctgttat cccaactatc aaaccatgtt tgccgaggaa gcgaaaagac 826981 aggatggcat agaggtagta tcgattgcca ctccgaacgg cactcattat gagatttgta 827041 aggcggcgct tgaagcagga gtgcatgtca tctgtgaaaa accgctgttc ttcacttcag 827101 cagaggggca ggaaatcaaa gcgctcgcag agaaaaaagg gaaaattgtc ggcgtgacgt 827161 acggtttttc aggcaatcaa atgcttcttc aaatgcgtgc gatgattgaa caaggaatga 827221 tcggcgatat tcgcgtggtt gacttgcagt acacacacgg tttttgtgca acagatgaag 827281 gtgaaaagat aagcgctgca cagaaatggc gtgtcgaccc tgcgatcgcc gggccaagct 827341 ttgtgctggg cgatttatct acccacacgt attatatgtc acagcttatt atgccaaaga 827401 tgaaaattaa ggagctgctg tgtgaccgac agagcttcgt cggcagccgc gcaccgctag 827461 aggataatgc ccatgtgctg atgcattatg aaaatggagc ggtcggaacg atgtggacat 827521 cgtcaatcaa tgccggatgt atggatggcc atagaatccg gattgtcggc tcaaaggcaa 827581 gcattgagtg gtgggacagc aagccaaatg aactgacgta tgaagtgcag ggagagccgg 827641 gccagacact cgttcgcggc atgccgtatt tagatgatgt ttgcaacgcc gatgaacgac 827701 tgggcgcctt acacagcgaa gggctgtccg aagcatgggc caatatttat cttaaatttg 827761 ccattgcgat agacgccaaa aaccgtgaag atgaagaaat cttgaacaac ttggtttatc 827821 ctgacattga tgcagggatc gagggcattc gctggattga gaactgcgtg cgctcggcaa 827881 accaagggtc agtttgggtt gaatttaaat aaatgaggga atgcgccgca tatgacataa 827941 agttcatatg cggtttttat tttccagaaa ctcctgtcaa aaatgccctg aggcaggtat 828001 gataagaagg gaattgggta tcgggagtga tgagcgtgaa agctcttttt tttacgagaa 828061 tgttcacctt gatggtgagc tgtttaatgt atctgtccat tgtgaaagag gataactggt 828121 ttggatatgt atttatagca gcaggtgctg ccatgtatgc agccaatcat gttttgctga 828181 caaaagagac aaatgccatc tggttctgcc tgattgatat tgcaatcggc ttttcgttcg 828241 gatttatctt tcccggcaca ggtttgttca ttattatgct ttgtccggtt gcggtcgcct 828301 tttttctgcg ggggtttcct aaaagaacag catggtctgt cttatgtctt tcctctattt 828361 tatttttgac cgtcctcatc cgtacatatg cgatgttcgg caatgaattt gtcattgatc 828421 atttgactag catgacattc gttgtcttct gcggtgtcgt gggcaaatta atccgcaagc 828481 tgttggatgc gcaggatacg gcaaaacagc agtttcagga actgacggag tcccatctgg 828541 cgctgtctgc tgcacatcag gagctccatt tatatgcgaa gcaggttgaa gagctgactg 828601 ccatttacga gcggaacaga atggcgcgtg aaatccatga tacagtgggg cataaaatga 828661 cggcccttct cgtccagctg cagcttttgc gtgaatggca aaaaagagac agccaaaaag 828721 cggatgagac agtaggtgtc tgtgaaacac ttgcccgtga agcgcttgat gatgtccgct 828781 tatcagtacg cactctgcaa actgaaaacg atccttcgct aatcgaatcg ctgaaacagc 828841 tgacagagga cttttgcaaa aatgcaggag tcacaacaga atttgcggtc agcggtgatc 828901 ctgcaatcat cccgctgtct ctccatccga ccctgatcag aacggtgcag gaagcactga 828961 ccaatgccaa acggcacggc ggcgccgcag cctgttcgat acagcttgcc tgcacaacgg 829021 acagcatcag ccttgtcatt aaggatgacg gcaaaggcaa tcctgaggca gcacttggtt 829081 ttggtctctt gaatatgaaa aagcgggcag cggagcatgg cggaatgatc cgctttgaaa 829141 gcgaacggga tcaaggattt actgtaaatg cagaattttc acttgccaat aaaaaatgga 829201 gcttcgggcc cgtgcagcaa aaggagagtt tatcatgatt aagatcatca ttaccgacga 829261 tcaggatatc gtcagagaag ggctggcatc cctgctccag ctccgagaag agctcgatgt 829321 gatcgcaacg gcgcgaaacg gacaggaagc cttcgaaaag gcgaaagagc tggagccgga 829381 tatcgtgtta atggacatcc gcatgccggt ttccaacggg gtggagggaa caaaattaat 829441 cacaagctcg ctgccaagcg taaaggtttt gatgctgaca acctttaagg attcagcgct 829501 gattgctgaa gcgcttgaag agggagcaag cgggtatctg ctgaaggata tgtctgcaga 829561 tacgattgta aaagcagtga tgactgttca ttctggcgga atggtgcttc cgccggaatt 829621 gactgcccaa atgctgaatg aatggaagcg tgaaaaacag ctgaaaggaa taaatgagat 829681 agaaaaacct aacgagctgc tcgacctgac cgagcgcgaa atcgaagttc tggctgagct 829741 gggatacggg ctgaataaca aagaaattgc cgaaaagctt tacattacag aaggcacagt 829801 caaaaaccac gtttcaaata ttatcagcaa gctggctgtc agggacagaa cccaagccgc 829861 catttactcg gtcagatatg gtgtatctgt cttttgacat atgacgtttt gcatatacgc 829921 ttctctgaaa aggcctttta caggcctttt tttcatgccc tatgttctat ctgccgctac 829981 atgccgcacg cctttctttc ttctacaatg gcaatggatc aaaaaaagga gtgagacgac 830041 gtgctgcaag cagaaaacat caaaaaggca tacggaaaaa aaacaatcgt gaaaggcatt 830101 tctttttccc tcaaaaaggg ggagtcgttc ggtctgctcg ggcctaacgg tgcggggaaa 830161 tccacaacca tctcgatgat ttccggcctt gtgccgcatg acagcgggaa catcacggtg 830221 ggcggctatg ttatcggaaa agaaacggcc aaagcgaaac aaaaaatcgg cattgttccg 830281 caggaaattg cattatatcc gacgctgacg gctcatgaga atcttatgtt ttgggggaaa 830341 atgtacggac ttacgcacgg tgaggccaaa aaaagagcgg ctgaggtcct tgaatatgtc 830401 ggtctgactg agcgggctaa agataagatt gaaacatttt ccggggggat gaaacgaaga 830461 atcaacatcg gtgcggcttt aatgcataag cccgagctgc tgattatgga tgaaccgact 830521 gtcggtattg accctcaatc gagaaatcac attttagaaa cggtcaaaca gctcaacgaa 830581 acgggcatga cggtgatcta tacgagtcat tacatggaag aagttgagtt tttatgcgac 830641 cggatcggga taattgatca gggggaaatg attgcgattg gcacaaaaac tgatttgtgc 830701 agccgccttg ggggcgatac catcattcag ctcacggtca gcgggatcaa tgaagcgttt 830761 cttgtggcga tccgatctct ggcccatgtg aatgatgtaa cagtacatga attagagctc 830821 aaaattgaca tttctgcggc tcatcatgag aaagtcgtca caagcctgct tgctgaagcc 830881 actgctcatc atataaacct gctgtctctt caggtgcagg aaccgaatct ggagcgcctg 830941 tttctgaatc tgaccggccg cacgttgcgg gattgaggag ggacggcaat gaaaaaaagc 831001 atatggatcg catggaaaga tgtgaaaatc agaatcacgg acagaaaagg gtttatgatg 831061 cttatcctaa tgccgctcat cctaacctgt attttaggcg cagcgctcgg atcagttgtt 831121 gacggaggca gccggattga tgatatcaaa gtcggctaca ttcaatcaga ccagtcagat 831181 acagcaaaca tgtttacaaa agatgttctc aaaaaaatga agtcgataaa ggtcacaaaa 831241 gtcggcagca aagacaagat gaaaaaactg attgatgaaa agaaaatcga tgtaggcatc 831301 gttatcccga accattggga agccggcaaa acctcagctg ttgttaatgc cgctcctgat 831361 caaacattga aaagttccat cattgaaaca gctgcaagct catttataga gcaatataaa 831421 gcggtaaagg aagccgcgtc aggctcaatg gactacatca gtaaaacgga agctgtaaag 831481 caaggaaaac ttgaccctgc acagtttgca gaaaagctgg caaagacgct agaaaaagaa 831541 acaggtgaca agcttactat tgcggaaaaa tctgtcggca gcaaagccgt taccagtttt 831601 caatactatt cggcggcaat gctttgcatg tttatgctgt ttcatatcac agtcggggcg 831661 aaatcatttt tacaggaaaa ggatacggag acgcttgcca gaatgctgat gacgcctgcg 831721 caaaaatccg tcattctctt cggaaaatgg cttgggacgt atctgtttgc catcatacaa 831781 tttttcatat ttctgatcgt cacaatcaac gtatttggtg tggactgggg cggtaatctg 831841 ctgttagtga gtgtactcgg gctttcttac gccgcagctg tatctggtat ttcaatgctg 831901 cttgcgtcgt gcatcagcga tatgaaaact gcagatgcga taggcggctt cggcattcaa 831961 ttgcttgcgg ttctcggcgg gtccatgctg ccgctgtacc aatttccgga cgtcttgcag 832021 tctgtatcca aagcggtgcc aaatcgctgg gcgcttgacg gctttctttc tttaatggaa 832081 gggggaggct gggctgacct tcaaaagcct gtgcttcttt ttgcggcgat cggcttttgt 832141 tcacttgtaa ttggtatcag acggcttcat acaagataag gaggtacaaa aggtgaaaaa 832201 aattctagcc atttgcggca ttgagctttc tctcattttt aagaagccac agaactattt 832261 gatcatgttt gctgccccgc ttttgcttac ctttgtattt gggagtatgc tcagcggcaa 832321 tgatgataag gtgcggcttg caatcgttga tcaggacgat acgattctct cacagcatta 832381 tattcggcag ctgaaggcac acgatgatat gtatgtattc gaaaacatgt ctgaaagcaa 832441 agcgtcagaa aagctgaaac aaaagaaaat tgccgggatc atcgtcattt cccgctcgtt 832501 ccagacacag ctggaaaaag gcaaacatcc tgagctgatt ttccgtcacg gccctgagct 832561 gtcggaagcg ccgatggtca aacaatatgc agaaagcgca ttggcaacgc tcaatattca 832621 ggtgaccgcg gcaaaaacgg catctcagac agcgggagag aactggaagg cggcgtataa 832681 aacggttttc gccaaaaaac atgaagatat agttccggct gtaacacgac agacgctcag 832741 tgataaaaaa gagggtgcgg aagcaagtga cacagcctcc agagcagcag ggttttccat 832801 cctgtttgtc atgctgacca tgatgggagc ggctggaacc attttagaag caagaaaaaa 832861 cggcgtatgg tccagattgc ttacagcctc tgtcagccga gccgaaatcg gtgctgggta 832921 tgtgctgtcc ttctttgtca ttggctggat tcaatttgga atattgcttc tttccaccca 832981 ttggctgttt ggcatcaact gggggaatcc ggctgcagtt attgtattag tgtcactttt 833041 tctattgacc gttgtcggca ttggattgat gattgcggcc aacgtcagaa cgccagaaca 833101 gcagcttgcg ttcggcaact tgtttgtcat cgcaacatgt atggtgagcg ggatgtattg 833161 gccgatcgac attgaaccga aatttatgca atccatcgct gaatttcttc cgcaaaagtg 833221 ggcgatgagc gggttgacag agattatcgc taacggtgcc cgcgtcacag atattctcgg 833281 aatctgcggc attttgcttg catttgctgc gatcactttc gcagcggggc tgaaagcgct 833341 ccgagcctaa aaaacatctg ccgtttaggc agatgttttt ttgcatgtgg gtacattcgt 833401 atgggtgcag cctgaactgc ggttaatcct tatctatcat agctaaaatt gattccagcc 833461 aagaaacgta atttttctcc cgctccagcg ctttcgttag cacaagatag tggccgaagt 833521 ccggtgaaga aaatgacatc ggctctgctg aagccataag cttttcatag cttccctgta 833581 agtcagaaag cttggcctgg cgtttttgca gctggtcttt gaacaaatca gaagcctcct 833641 ggcgcgatag acaagaaatg aaataagcct tcagcataaa ttcatccttc accgtctcgg 833701 gtatcggctg gtggcggatc agccagtcat gcagctcctg ctttccgctg tctgtcaggg 833761 tgtacatctt tttctccagc tttgtgccct gaatcgttgt ccggaacgtg ataaatcctt 833821 catccgtcag ctttttgagc tcagggtaaa tctggctgtg cttggcgctc caaaactggc 833881 cgagctcctc tttaaaataa ctcgtaatat cgtatccact caattcgcct tttcgcaaaa 833941 gccctaatat ggcgtatttt aatactctca tgctatcctc cgtgtctggc tgtttcgcaa 834001 aacagatgag ccggtgctca actgtgattc taactgccta ttccccttat tatagaaaag 834061 ggaggaaggg aacacaaccg ggctctttgg aaatgaagat aaaaggtttg tcagaaggta 834121 tccgatttat ctccgtcaat ataaaagaga tttaaattta attttcagaa aaaatagtaa 834181 cgatattgat tttttatata taataggaaa ttggtggtat gaaaattttt tgggggaata 834241 aacgtgaaaa aagtacttat ggcattcatt atttgtttat cgctgattct atctgtttta 834301 gccgctccgc cgtctggcgc aaaagctgag tcagtacata atcctgtcgt tcttgttcat 834361 ggaataagtg gtgcatcata caactttttc gctattaaaa actacttaat ttctcaaggc 834421 tggcaaagca acaaactgta cgcaattgat ttttatgata aaacaggaaa caacctaaat 834481 aacggcccgc agcttgcttc atatgttgac cgtgttttaa aagagactgg ggcaaaaaaa 834541 gtagatattg tggctcatag tatgggaggc gccaatacgc tgtactatat taaatattta 834601 ggcgggggca ataagattca aaatgtcgta acgcttggag gggctaatgg tttagtgtca 834661 tcaaccgcgc tgccgggcac agaccctaat caaaagatcc tctatacatc tatttacagt 834721 ctcaatgatc aaattgtcat caatagcttg tctcggttac aaggagcgcg aaacatccag 834781 ctttatggca tcggtcatat tggcttgctt tctaatagcc aagtgaacgg ctatatcaaa 834841 gaagggctga atggcggagg cctcaataca aattaatatc ttcaaaaaac aacctgctgt 834901 ctccgttaca gtgggttttt tcgtctgaga aagccatagg gtcttatgac cttagtctat 834961 catgcatacg tcaatttatg acatcaggca ctttttcaaa tagagcggac atgttaaggt 835021 acaaccatcg atttctatca atttgaaata aaaggagcgc tgttatgcaa attaaagaaa 835081 tttttatgat ccgctgcatt tcgtgcttaa gtgtcgtctt gctccatatc atttcaatgg 835141 tcctgatgct tcaggcagaa gctcttgcag atatttctca cactgttgat tctttccgca 835201 cactcctgat gttcagcacg cccgctttta ttttcatctc tgaattttta ctggcccgtt 835261 cttatcctga tggggtgcct gacggttttt taaagaagcg gggaaaagtg atttttgttc 835321 cttttttatt tatcgcagcc atcgatgcgc tgctgatgac cagtgcgatg gggggagagg 835381 taacctttct cgcgtttgtg caaaaatatc tggcgaacgt attcttagga aactttatcg 835441 gatacttcat tctcgtcatc tttcaatttt acatgctgca tatgatgttt catgagtatt 835501 tgaaaaaagc atcgccgaaa tgggtgctgt ctatctcatt tgtggtgaca gccgcttatt 835561 taggctattt ctccgcagcc agcccggctc ctgcttctga agagggaggg gcatttccgt 835621 tcttctgggt tccgttcgca ggctggcttt tctacttttg tctagcctac tattgcggaa 835681 aagaatacaa gcgtttttta gcgctgctga accaataccg ctgggtggtg tacggcgccg 835741 caattgcttc tggggcgctg gttgtcactg tttcttatgt cggtgaaatc ggcatgatca 835801 gctcgaagcg gcctgatatc atgctgtatt caacaagcat gattttcctg tgttttcatt 835861 tgttttccaa aatgaagcat gtgccgaaaa tcatgatgtt tatcagcaac tattcctttt 835921 cgatttatct gcttcatgcc tattttatga ttataggcta cgtgttgctt ttgaatatgc 835981 ccgaaattcc tgccgtaccg gctgttctcc tgttgtttgc cgtgtgcaca gccggcccga 836041 ttatgacctc atgggcgctg aataagttca aatacgggta tttatttgtg gggaaaattt 836101 atcagccaaa acagaagaag gtaacagtcg aagtgcgtga tcacgcaggg tgaaaaacaa 836161 gcggcaggag ggctcctgcc gcgtttcttt acttctcatc cgcttgcaga actgttttta 836221 aatatagttt tgcagactca gcaagtccag atacatcagc cttttcttca tcgaaataca 836281 gggcgttttg aatgatgccg tcattcatat tgaggaaaaa cttggcgata gtcgcaagag 836341 gctgaaccgg ctgaaactct ccctgatcga tccctttttg caatagcctt gaaaaccttt 836401 ccacaaaaag atcatacctt ttctccaaat actgccgccg ttcttcattg cgccaagctg 836461 tcactaaata ttcaaattgc accggcgcca gcgtatctgc tacatctcgc aggccctcag 836521 tcagttcatc caaatagctg gaaatggagg cccaaacact ttggtgttca gctgatttat 836581 caagctttcg gagtccttca tccagccctg tttcaataat gcggcgaaac atctcctcag 836641 tgcttgaaaa ataaagatag acaccgcccc ggctgaaacc tgactcttct acaacatcct 836701 tcatcgtcgt taattcgaat ccttttcgtt taaaaaccgt tttggcagcc tctaaaatct 836761 ctgcctgccg tttatccttg tgctcctttg ttacttttgg tgacaagata tcgcctgctt 836821 tctgcaattt tcttacctat aagtgtaatc aacccaatca tgatcagcaa gcagccacag 836881 acaagaaaag caagtgatac accgatccat tccgccagca cgcccccgcc cgccatgccg 836941 aggatagagg cgagggttgt cgcactctga atagcgccga acaccctacc gctgtaatcg 837001 acaggcactg ttgtttgcac gagaatctga aatggaatat ggacgaggcc gaaagccgcc 837061 cccatgatga aaaaagcaaa tataaagaga gtgatgccgg caattcccat accgcttagg 837121 aatggcgcac ctccagttgc tagtccaaga agaagggttc cagctgagaa ataaagcaaa 837181 taagaagtga ttcgccgtct gccggtaatg gccgctgtaa ggagcatccc ggctccgctt 837241 acggccatgc accagcctgc cagctcgggc ggagctcctg aaaaggagcg gataagaata 837301 atcgcttggg aatcaccaat ctgcaaaaca aagagaacga cacaagctgt tagtaagcct 837361 gttaatagaa gcggcatccg tttcaaaaac tgaaggcctt ccttgataga agtaagtgct 837421 gctgtttttt cttgaggtgt attggctttt tgtaaaaaag catctctggg aaggaaaaac 837481 aaaatgacag cggaaagaaa gaaggcgccg gcgtttatat aaaaaacaga gtgtatcgag 837541 aaagcagcga tcagcgtgcc gccaagggca gggccgaaga tttttgagct gttatcaatg 837601 atgctgctga cggaaacggc ctgctgaatg tgtgcttccg gagccaattc cttaagcttt 837661 ccgtttttag caggtaaaaa aagtgaagaa aaacagctct gaacggatag caatacgtaa 837721 agctgccaaa gctcactgac ataaacgcag ctgataacag tgagggcacg gccgatttca 837781 gatagaaaca tgatcgtttt tctgtcaaaa cggtcggcaa gcagacccga tacaggtccg 837841 agtacaatga caggcaaagc aaacgacatc attaaaagcg acatatctaa tggagaagca 837901 tgaagctgaa aagcggctaa tgttagcacg gccaaaatgt gaagccagtc tccaagtgaa 837961 gaaatggttt gcgaggctaa cagtgtcatc agtccttttt gattgcgaaa caacggtttt 838021 tccatgattc atcctcctga ttattaaaat gacactagtg tcgtttttaa ttgtatggga 838081 aaaagacaca atatacaatc tttttcttgt aaaataaagg agaagattga atagaaggga 838141 gaacattcat gacatcagtc aatctaagct acccaatagg agaatacaag ccgagggaat 838201 ccatatcgaa ggagcaaaaa gataaatgga ttcaagtact tgaagaagtg ccggcaaaat 838261 tgaagcaagc tgtagaggtc atgacggaca gccagcttga cacaccgtac cgggacggtg 838321 gatggaccgt tcggcaagtt gttcatcatc tggctgacag tcatatgaac agctatattc 838381 gttttaaatt gagcttgacg gaagagacac cggctatccg tccgtatgat gaaaaagcat 838441 ggtcggagct aaaagactcg aaaacggcag atccgagcgg ctcactcgcg cttttgcagg 838501 agcttcacgg aagatggacg gctctgctcc gcaccctgac ggatcagcaa tttaagcgcg 838561 gattttatca ccctgataca aaggagatca ttaccctgga gaacgcgctc ggcctgtatg 838621 tctggcactc acatcaccat atcgctcata ttacggagct ttccagacgg atggggtggt 838681 cttaacgctt ttgccggcgg aaagccggaa tactgatagc agcaatcacc agaagtgaga 838741 ccacagcagc cgctgcatat aaatgatcat agccgctggc gacactcgca tgaatggcgt 838801 cgcttatcgc ggttttgact tcaggaacgg gaatgcgttc gatttgttct tgtaaagaag 838861 aaacttcaga actgtcgatc tccggaatca tctgcatcgc cttttctgaa tatccgctgt 838921 ccgataagcg gctgttgatc tcatcaccta tttggtcaaa cccggctgtg ataaaacctg 838981 cataaagagt aggcgccaag gtcagtccaa tttgccttac taatgaaagc gtgccaagag 839041 ctgtaccctt atttgttttt gccgcttctg atacaaggac gttcagcgga gcgcctaaca 839101 gaaagccaaa accgatccca gctgccacac ttgcgatcac aaactcccat ttttccgtga 839161 cccagagcgg aaataaagca aaccccgcac atgagatgat tcccgaaaga ataacggttt 839221 ttacaggacc ttttttgtcg gtaagtgctc cgccaagcca agcgccgatt ccggaagcca 839281 acgcaagcgg tgtcatccaa tagcctgctt ttgcggcagg gacacccaaa tactgttcga 839341 catatgacgg gataaaaatg actgccgcca agagcccccc ggataacaaa ccgatgataa 839401 gcgtgcgctg aaacatatgg tttcgcagca gagaatacgc caaaatggga tcgcctcctc 839461 gcatttcaac tctcttttca tacgagataa gcgctgcaaa acagagtatg ccaaaaataa 839521 tacatccata aacctccgga ttccccaagc tgtgtaagag atttgccccg tcaagattgg 839581 tcatgccgta catcacagct aaaatcgaca gggacaaaag gaagattccg gccgcatcga 839641 ggcgcttagc ctcaggtgct tttgtttccg cgataaaaca tgcgccgaaa acaaccaata 839701 gcacggcaat cggcaaatta atcaaaaata gccaatgcca agacccggtc caatcaagca 839761 gaaagcttcc gatatttggc ccgagcacag cggccatccc gttcattgcg ccaagcagcc 839821 caagcgcctt cccctgtttt tcctttggaa gggtcgcgag aatgtgagag ctgccgatga 839881 tgaaaatccc gccgcctcca agcgcctgaa tcagccgcga tatcagaaag agcgggaagc 839941 tttggctcaa agcaacaagc aaagaaccaa gtccgaacag gcaaacctca atgagaaaga 840001 gtttttttct gccgtagcgg tcggaaagtt ttccgacgat tggcacactg acgctaagac 840061 cgagcgtata aagggtaatg ccccatgatc cccaggaagg ggaaacggaa aacgactcgt 840121 ttatcgttgt taaagcagcc gaaataattc cgttatctaa agcagccata aacacgccaa 840181 tcgtaaacag gctgattgcc cacttttggc ttttctgctc tgttaatgct tcagacattt 840241 tcgtcaactc cttttagttc acttgaaata tattattcat tttaaatgaa ctaaatgtca 840301 aataaaaaaa gcctgctccc gcagtttgcg gatgacagac ttactgattt attctttttt 840361 cgcattctct aatgctcttg aaaggataga cagcccttcg taaacagcct gcttttcttc 840421 aggggacagc agctctaatg aacgcttcaa tttcaggtgg cccttttcat acaaaccccg 840481 gaaaatcttt ttcgcattct ctgtcaactg aacaactaca gagcggcggt cctcttcaga 840541 atgtgagcgt ttgacaaatc ctgatttttc aagccggtca agcagcccag ttgtattgga 840601 cagggaagcc cccatttttt cagcaatgtc gctcactttc aatgttccat ggttgtttaa 840661 tagcatcagc accttcattt gcggcatgct catatccagt ttcatccact cggacacatc 840721 accgagcccg gcggacgtta agactttcat atagagcacc catatttccc gttcctccga 840781 tgaaagaatg ttttcgttta agactgttgt atcgtgtaaa ttatattcca tttcatcact 840841 tcctcatcat tcactcctct taccatatta ctcgattttc actcctgaaa gaaagtgagc 840901 agaaaccgca tgcgggactt tgtccgaaaa ataacggtag tgtataatga gttggagatt 840961 attgggggag aggatcgaac tagaatatga ttggagagac cattgctgat taaaaagaat 841021 gctttatcaa tattaaaaat cgtttttcct attgctgttt tgctatttgt tatttatcaa 841081 tcgaaaaaag aactgacaaa tctgtcattc aaacgtacgc tcatggtcat caacggactg 841141 gaacgaacgg atttattcat gcttgtgttg atcggcttgc tggctgttgc ggctatgtcg 841201 ctgtatgatt acgtcctgaa gtactcactg cgcctatcga tcacaaacgg aaaagttttc 841261 agggtttcct ggatcgccaa ttcatttaat aatgtgttgg gattcggcgg tttagccgga 841321 gtcgggttaa gaatgatgtt ctataaggag catacgaaag accataaggc actcgtgaaa 841381 ggaatcgcct ggctcacatc atctatgctg ctcggattat ctgttttcag cattttcgtt 841441 gctgcgagag tgctgccagt tgatgaagtg attcatgaga agccttggct gtgggcggtc 841501 gttatcggtt ttgcactgat attgccgtta tctttagcgg tgtccaaaat aaaagaccgc 841561 aaagctgggg acgaagagaa tgcggataaa gtgaaaaatc cgattttcgc atatattgga 841621 gcttcagttg ttgaatggct catggccggg accgtcatct attttgcttt gttcgctatg 841681 ggcattcatg cagatatcag gtatgtgttc ggggtgttcg tcattgcggc gatcggagga 841741 atgatcagcc tcgtgccggg cggcttcggc tcgtttgacc ttttattttt gctggggatg 841801 gagcagcttg gctatcatca agaggccatc gttacttcta ttgtgttgta caggctcgcc 841861 tactcattta tcccatttat cttgggactg ttctttgccg ccggcgacct gacggaaaat 841921 acaatgaagc ggctcgaaac gaacccgcgc atcgcaccgg caattgagac gacaaacgtt 841981 ctgcttgttg ttcagcgtgc ggtattagtg agaattttgc aaggctcgct ttcccttatt 842041 gtgttcgtag caggtctgat tgtcttggcc tcagtttcct tgccgattga caggctgacg 842101 gttataccgc acattccgcg cccggcgctt ttgctgttca acggcctgtc cttaagctca 842161 gcgctcattc tgctcatttt gccgatcgag ctttataaac ggacaaaacg ttcctacacg 842221 atggccatta cagcgcttgt cggcggcttt gtgttcagct ttttaaaagg gcttaacatc 842281 agcgcgatat tcgtactgcc gatgattatc gtattgcttg tgctattgaa aaaacaattt 842341 gtccgcgaac aggcatccta tacactggga caattgatat tcgctgtggc gctgtttact 842401 gtggcgctct ttaactacaa tctgatcgcg ggctttattt gggaccggat gaagaaggtg 842461 ctgcgtcacg aatatttcgt ccacagcacc tcgcatatta cacatgcaac catcatggcg 842521 atcatcattg tgccgctgtt cttcttgata tttacagtgg tctatcataa gagaacgaaa 842581 ccgatcggag agaaagctga ccctgagcgt cttgctgcgt ttctcaatga aaaaggcggc 842641 aacgcgctga gccatcttgg ttttcttgga gataagcggt tttatttttc tagcgatgga 842701 aatgcactgc ttctgtttgg gaaaatcgcc agaaggctgg tcgtgctcgg cgatccatct 842761 ggccaaagag aatcattccc gctcgtgctg gaagaatttc tgaacgaagc gcatcagaag 842821 ggattcagtg ttttgttcta tcaaattgaa cgagaggaca tggcgctgta tcacgatttt 842881 ggctacaact tctttaaatt gggtgaggaa gcatatgtag atttaaatac atttaccttg 842941 actgggaaga aaaaagccgg ccttcgggca atcaataacc gctttgagcg ggaggagtat 843001 actttccatg tggatcatcc cccattttct gatgcgtttt tggaggagct gaagcaaatc 843061 tcagacgaat ggctcggctc gaaaaaagag aagggattct cgctcggatt ttttgatcct 843121 tcctatttac agaaagcgcc gatcgcctat atgaaaaatg cagaaggaga gatcgttgca 843181 ttcgcaaatg tcatgccgat gtaccaggaa ggagagatat cggtcgatct gatgcgctat 843241 cgcggcgacg ctccaaatgg cattatggac gcattgttta tccgtatgtt tttatgggca 843301 aaggaagagg gctgtacgtc atttaatatg gggatggcac ccttggccaa tgtcggcact 843361 gcctttacat ccttctggtc cgaaaggttt gccgctgtca tttttaataa tgtcagatac 843421 atgtacagtt tcagcggcct aagagccttt aaagaaaaat ataaaccgga gtggcgaggg 843481 aaatacttag cgtatcggaa aaacagatct ctttctgtca ccatgttcct cgttacacgt 843541 ctgattggca aaagcaaaaa agactccgtc taataagacg gagtcttttt ttatttcgtt 843601 tttaagaagt aggtttcaat atcatcaagc aggtagtttg cggctttaat tccgcctgcg 843661 gttgtccata cgacgtcatc gacttcatgt gcattacctg acttcacggc cttcaggttt 843721 ttccatagtg aactgcttgt ccactgattg gcccattttt cattttcttt tgcattatcg 843781 gctttataag tgaaataaaa cagcacatca gcatccatat caggaataga ttctttactg 843841 tcggttgaga acgtaaattg gtccttttgt ttcttaaaca gttccacttg tttttcaggg 843901 cgtttgaagc caagctggtc taaaataatc ccaggaaatg aatcggtata atagattctt 843961 gattcaccgg ataaaaagcg tacgactgaa acggttttgt ttgtctggtc gcccagcttg 844021 ttttttaaat cagaaacacg tttatcaaaa tcggcaatga cttccttgcc tttgtccgcc 844081 ttattcaccg cgttggcgta tagagtcagg ttatccttcc agttcccggc caaagattca 844141 gcaaaaacag tcggcgcaat cgcatttaac tgatcataaa ttttttcctg gcgcactttg 844201 tttccaataa tcaaatcagg ctttaattct gcgatggctt ccacattcgg ttccgtttca 844261 agaccgacgt ttttaacacc tttcatgtca tctttcagat agtcatacca cgggtcgccc 844321 ttccatgact ttacggctcc gaccggctta atgccaagcg ctaagagcgc ctctgttcct 844381 tcattagtta aaacaacaat ccgttttgga ttggcgggga tgttgtctga tgtccccatt 844441 gcatgtttga ccgttcttgt tttgctgctt gacacctcgc tgttgcttga actttctgaa 844501 ctattacagg cagaaagtac cataacggcc attaaaaata cgaatagcat gctgatatgc 844561 tttttcatct ttttcctccc aatattgaaa ttcattatca tttagatcat aataagcagt 844621 gttaagagtg tcaatcccta attgaggatt attctcaaaa acaaacatta catagtaaat 844681 aactaggaga attagatcat gatctgcaaa aaggcatctt caaaatggat tgtgttagta 844741 tgtctgattt tcattttact gacggctgtc tgcgcaagcg tcgtgtatgg ctatacaggt 844801 acgtcatgga gacaggtcta tcaggcgttt acttccttca atggaacaaa tgagcatgtc 844861 atcatcaagg atgtcaggct tccgcgcgct ttggttgcga cagtcgtcgg cgcctcgctt 844921 gcagccgcgg gcgctctcat gcaggcgctc acaaaaaatc cgcttgcgtc accggggatt 844981 ttcgggatta acgccggtgc aggttttttt attgttgccg gatcgttttt tctgcatatt 845041 cagtcacctc aggcattagt atggagctcg tttctggggg cagcatttac cgctgcgatc 845101 gtctatgcag caggctcgct tgggagggaa gggctgacgc caatcaaact gacgctggcg 845161 ggagctgcca tggcagccat gttttcttct ctgacacagg gcttgctgtc tgtcaacgaa 845221 ctcgagcttg cccaggtgct tttttggctg actggctctg tgcagggccg gagtctggat 845281 ctgttgatga cgatgtttcc atatgcagcg gcagcgctgg taatctgctt ctttctcggc 845341 caaaaaatta atctcctcgt tatgggagaa gatgtggcaa aaggactcgg ccaaaaaaca 845401 ggcctgctga aatttgtgat ggcgctttgt gttgtcatgc ttgcagggtc cgctgtcgcc 845461 attgccgggc cgatttcttt tatcggcatc attattccgc attttgcccg ctttgtcgtt 845521 ggtaatgatt atcgctgggt tctgccattt tccgctgttt tgggtgccat tttgcttgtt 845581 tgcgcggata tcggtgcgcg atatatcatt atgcctcagg aagttcctgt cggggtcatg 845641 accgccatca tcggaatgcc tgtgtttgtg tacatcgcaa gaaggggggc gaagctatga 845701 aacttcgttt tggcgttact gcggctgaaa agaaagcatg gatcgtcttt ttggttttac 845761 tggggttaac agctgctgta ctcatcataa gcgctggtct cggacaaagg tttattcctc 845821 cctgggatgt agcaaaaaca ttctttggtg caggttccaa gctggatgaa ctgatgatca 845881 tgtcgttccg catgccaaga attttgacgg ctttatgcgc cggtgtctgc ttggcagcgg 845941 caggcgcgat attgcagggg ctcgtcagaa accctctcgc atctccggat attatcggaa 846001 taacaggagg agcggcggta gcggtcgtgc ttttaatgat gttcttctca gaccgcagca 846061 gttcacttac gatcagtctg tcatggcttc cagcagccgc atttatcggc gcatcggctg 846121 tcgggctcat cgtctattta ctggcataca aaaatggcgc ctccacattt cggctggtgc 846181 ttatcggaat cggattttca atgtcggcgc aggcgatgac taccctgttg atgatcaaag 846241 gcccgattta ccgagcatca caagccaatg tgtatatcac tgggtcagtt tatgggtcaa 846301 actggcagca tgtaaaaata gctattatct tatctgtcat tctcttattc atttgttttg 846361 tcgcgctaaa aaatatgaat atacaggtgc tgggtgaaga tattgcggcg ggtgcaggaa 846421 gcgctgtgca gcgaaatcgt tttttcttgc tccttttgag tacggctctt actggttgtg 846481 cagtttcagt tgccggcaca atcggttttg tcgggctgat ggcgccccat attgcaagac 846541 ggcttgtcgg ctcatcttat ggcgcgctgc tcccagcgtc ggcacttatt ggagctctgc 846601 tcgttttaac agctgatatc gtcggcagaa ccttatttgc tccggtggaa gtgccggccg 846661 gcgtctttac agcggctatc ggcgcacctt attttattta tttgctctat aaaacaagaa 846721 attcttaatc gttacaccca ttttcttaaa aaagaaaatg ggtttttttg ataatgactg 846781 aagattcgta attatttttg ctatactgac agagacattg ataaagaaag ggcggcagat 846841 gaatgaaaga agcagaggta ttaaaatatg aagcatttac aagcagtccc ggcaaaggaa 846901 accccgcagg cgtcgttttg cagggagacg attatacgga agacgagatg cagatcatag 846961 ctgaacgtgc cgggtattca gaaacctcct ttatccgaaa aagcgagtcg gccgatcttg 847021 aactccgtta ctttacccct ggacacgaaa tgaatttgtg cggtcatgcg acagttgctt 847081 ctctttacgc attatgtgag aaaggaatgc tggagagcgg taaaacgtac agcatccaaa 847141 cgaaagcggg tatcctgcct gtgaagattt ctgaaaaaga tggccgcatt catatcacgc 847201 ttgaacaggc ctctccgcaa ttcaaaccat ttacaggcga tcggaaaaaa cttgcggacg 847261 cactgggtat caccgatgaa gattttcatg aagaccttcc gattgtgttt ggcagcactg 847321 ggatatggac agccatcgtt ccgcttaaat cattggaggc ttccaaaaaa atggtgccag 847381 ataacaaaca atttccggaa gtgttagttg atctgccaaa agcttcagtc catccgttta 847441 cctttgaaac cgtccatccc gacagcgacc tgcacgggcg ccacttttca tccccgtatt 847501 cgggaacgat tgaagacccc gtgaccggca cagcatccgg cgtgatgggg gcttatatga 847561 aacattatgg caatgccgag cagcataaat ttatcattga acaagggcag gaaattggaa 847621 aagacggaaa agtggagatc gaaatgaacg aagccggcgg ccatgtgaaa gtgaacatga 847681 caggaacagc cgtttactca gaaacccgta ttcttaaaat ctaatacgga tgatggttta 847741 caaaaagatg cactttccgt tatcattatg aaatgataat cattttcaat tgcataggaa 847801 ggtgagacgg tatgcctcaa accgaacaaa tacatcagca ttcagtactg agggacatca 847861 tacgcagcag aagatcgatt cgaaagttta aacaagagcc agtaccttca gcagtcattc 847921 ttgacatgct tgaaacggca aaatatgcgc caaatcacag agtgacagag ccatggagat 847981 ttatttacgt ttccagtgag acaggtaaag cgaacctcat taatacattt gcagcgttct 848041 ctaagaaatc caagccggat atgacagagg aaaagcttca aaatttcaaa aacacacttg 848101 ggcgcgttcc gggatttctc ctcgtcgtgt ttcaggaaga tgaaaacgaa agagcgcggg 848161 acgacgattt tgcggcaaca agctcgttga ttcaaaatct tcagcttctc gcttgggaaa 848221 aaggaatcgg catggtttgg aaaagcggaa aaatccttta tgacaaagaa gtccatcagg 848281 cctttggttt acaggataat gagcgtttcg ccgccatcat acaaacaggt tatcctgacg 848341 aggcgccgga agtgaaaaaa cgcacaccga tccgcgaccg attcactgaa atgtaaaaaa 848401 ccccttgtct caaacggaga caaggggttt ttcattaacg agatttcttt ttcgctctgt 848461 tgtcggctgc tttcgcacgc tcttgcgctt cgcggtcatc tgcatcagca agctcggttg 848521 aatattcttc gtaaacgccg tcagtttccc tttttaaggc atcgggaact tgtggaagct 848581 tttgtttgtt tttatcacgg tttttgtgga tatgatttct gcccatatca aattccccct 848641 aaaaagtgat atcaaacaaa tatagtattt ggttttaagg ggctatgtat tcctacttcc 848701 gcttagcagc tttttccgct tttttaaatt cgcctgaata aagaacttcc tgcatttttt 848761 tcaggttggc gccttgctgg tgcttctccc tctttttttc cataaaaagg acctccttca 848821 accatgttat tcttaaggtt gacgcttcct gctgttttta tacagtcttt cggtccgcta 848881 tcagctgtga gagtgcaaat tcaagatccg aatatgtaaa acgaaatcca gaggttatcg 848941 cttttttcgg aagagcgcgc tgtcctttca caatcaaaag actcatttca cccaatgctt 849001 ttgataaaaa gaattccggg acggggagcc agtgcgggcg gtgcttcacc cgtgcaatcg 849061 tttttccgaa ttgcttcatg tccacaggat tgggcgcggt gacattcatt gggcctgaga 849121 tgccggcgtt ttccaccgca tatcggatca tctgggccgc atcctcgaca tgaatccatg 849181 acagccactg ccttcccgtt ccgatcgttc cgccggccag aaacttatag gggagaatca 849241 tgagcgggag agcgcctttt tctccaagca tcacgccaaa tctcgcataa actgtccgga 849301 tgcccatcgc ttcaatatgc tgtccttcct tttcccacag gtgtgcagta tggctgagaa 849361 aatcctcatc tgacgttgca gaatcctctg tgaaagtttt ctcaaggctt gtgccgtaaa 849421 tgcccacggc actggcttgg atcaatgtct tcggcttctc cttctgtttc tgaataagcc 849481 gctgcacttc acgcgtcgca ttgatacggc tggagagaat gtgctgcttc gttttttctg 849541 tccagcggcc aaaaatcgat tttcccgcaa gatttatcca gacatcaata tgaggaagtt 849601 cctgctccgg tgcggctcct tccgacagcc attggacata tgtcatattt ttttgttcag 849661 tttcccttgc gtttcttgat aaaatataaa catggtgtcc ctggcgggta agaacgcctg 849721 tcagatgctg gccgagaaaa ccggttccgc ccgtcattgc gatattcatg aacatctctc 849781 ctcatcgttc taataaatat actttacctc attgtaataa aagaaaacgc gtttcaggcc 849841 tgagaaggga gattaagatg ccgtttatta caaaaatatc aacgcaaaaa aagaatacgg 849901 aacgcttcaa tatttttctg gatgataaat acgccttcag cgtggacgcg gatgtgctcg 849961 tgaaatttga gctcaagaag ggaaaagaac tcgatgatct tgacatcatt gagattcaat 850021 acggcgatga agtgaagaaa ggcttcaacc gtgcgcttga ctttttatcc tatcgaatgc 850081 ggtcgacgaa agaggtcgag gatcacttaa agaaaaaaga aacctcgccc cccgtcattg 850141 cggaagtcat ccataggctt aacgattaca agtacttaaa cgaccaggaa tttgccgcag 850201 cctatgtcag cactcacaaa aaaacaaacg gaaaaggccc tgatgttttg ttcagagagc 850261 taagagcgaa gggaattgat gacgatacaa ttaaggaggc gctaagttcc ttttcctttg 850321 aagatcagac aagagaagcg gtcaagcatg ttgaaaagct tctcaaaaaa gataaaaagc 850381 tttcgacgaa agaactcaaa cagcgcgccc agctgcagct tcagcgcaag ggcttctcat 850441 ttgatgttat cagcgcggcg atggatcaga ttgaatatga aaatgatgaa gacacagaga 850501 aagaagcgct gcgccttcac gcggaaaaag cgtttagaaa ataccgctat gacggctcat 850561 atgaaagcgc catgaaggtc aaacaatttt tattccgcaa aggattctca ctcgatttaa 850621 tcgagcaatt actgcaggaa gaggagtact gaaatggaga aacgatacag tcaaatgaca 850681 ccgcatgaac tcaataccga aatcgcatta ctttctgaaa aagcaagaaa agccgaacag 850741 catggaatca taaacgaact ggcagtgctc gaacggaaaa ttacgatggc aaaagcatat 850801 ttgctgaacc cggaagatta ctcaccggga gaaacatatc gtgtggaaaa cactgaggac 850861 gagtttacca tcagttattt aaatggcgtt ttcgcatggg gatacaggac ctcttcccct 850921 cagcaagagg aagcgctgcc aatctcagta ttgcaagaaa aagaataaag cgtaacagga 850981 ggctgatgat cagcctcttt ttgtttgcag cacatttaca cgaattctta aagaaaaaat 851041 cattgaattc acttgaaaaa tcttttaaga tgaaactcgt tgttttttaa aatcaaagga 851101 ggcgatgacg ttgagtatca aaaacccatc tgtaaaattt attatatttg ttcttatgat 851161 ttgtacattt tcaatcggct atacagaata cgcggtgatg ggtattttga cgtcgattgc 851221 caatgacttt catatacagg tttcatccgc agggcttctt gtcacggctt atgcggcaag 851281 cgtttgtttg acagggccgc tcgtcaccat catttccgtc aagcttccga gaaagcctgt 851341 gcttcttggg ctgatggcga tatttatcct ttccaacctg atgagcgcac tggcgccgaa 851401 ttttgcggta ttggccattt caagaatttt atctgcgtcc attcacggcg ctttcttcgc 851461 gattgccatg gtattcgcaa gtgaaatggt tccgccggaa aagcgtgctg cagctgctgc 851521 ttcaatgaac ggcggactga cagtggctct aatgcttggt gttccattcg gctcttatct 851581 cggagatgtc ctgaattgga gagcggtgtt ttccatcatt acggcacttg gtgtcatcgg 851641 atttttaggc cttatggctg ccgtgccgaa cagaaaacca aaagtgatcc caatgcttat 851701 gaatgagtgg ggtgttttta aacacaaaca agtgctgttt tccttcgcga ttaccatttt 851761 aggctattcc ggtgtcttta tcgcctacac ctttatcgaa cccattttga ggcattcagc 851821 cggattcagc acggttggca ttacaggtgc tctctttgcg tatggattgg gaggcgttgc 851881 cgggaatttc tttgctggaa aggtaccgct gcctttgctg actcggacga tgatcggcgt 851941 aatgatcggt ttaatcggtg ttctggctgt atttccttac atcgccattt acccggctgc 852001 agccattgtg gcaacgttcc tattcggggc atgcgcattc ggcacgccgc ctcttctgca 852061 aacaaaggtc atttcctcat ctgagggcgg cacaaccatt gccgcagctg tcagcgtatc 852121 agcatttaac cttgccaatg cccttggtgc atggatcggc ggaatgattt taaacggaac 852181 aggctcttat tcctggctgt ttgcaggagg tgcgcttatg accgcatgcg gacttgtgct 852241 ttctaccttc gcacacttat cagaaaagaa gagcgtctac gaatatcaag tcaataaagg 852301 gtaaaaaaca gctgcagtgt atgcagctgt tcttctttac cgtttgcctg aggctctcat 852361 tctttcttga ggatgctgat tgatagatcc gtcagcacgc tttgaagcat agtcgtcctt 852421 tgctctcggt tcaccctgaa atttgttttc gttttcgtaa ggaaatcctt tttctttatt 852481 tcggaccatg tcatatcccc ctaggttcga gatcaaaaag ttgcgtcttt tcagatgaag 852541 acgtaaggtt agtatatgga gaacaccacg taataaagcg ttattttttt cctgaagaaa 852601 ggagactgca cacatgaata tgtacattga gaaactgact aatctgcttc tggaaaagaa 852661 cgagatgatc agctatatac aggcaaaaac gtgggtggaa ttgttatgga gcgatttcga 852721 agcaacctac gcaaaagccg gacacgccta tcaaggtgaa aaaatgactg aaaaaatcgt 852781 cacacaatgg attgaaaact atggcggcca gctccacctt tttcaaagct cccgtaacga 852841 cgtgaatgat tacttaaatc aaagcagagg ccttttgcat taaaaacctg ccgttaacga 852901 ccggcaggtt ttttcatttt cttaaaatta ccttaacagg aagaaatcat aaacaaaaca 852961 tgtttcacca gcctgtcaat cagggaatac cacttatatc ttgtcaaaat gcgaggagga 853021 gctttatatg aaaaagaaac aagtaatgct cgctttaaca gctgccgcag gactgggttt 853081 gacagcactt cattccgctc ccgcagcaaa agctgcgccc cttcacgaca tatctgtcag 853141 catgccatca tccgatactt acatcataaa agcaggaaag ctgaatgtcc ggactgagcc 853201 aaatcatgaa ggtgatattc tcggcactgt atcatcagaa caaaaggtaa aagtcgatag 853261 gttcgtaaat gccgattggg ctcaaattca tttcaaagga aagaaagcat atatttcaac 853321 tcacttttta atgaaaaccg caagccaagc gaaaacaacg aaacagacag ccttctatac 853381 accgacgccc gaaaacggaa aagctaagca gctctcatct ggaacagagg tgacaatact 853441 tgggtgggga ttcagtgaaa acggcggatt tgacttcact tgggcgttcg tggattatgg 853501 cggagttaaa ggctatattc acacaaagga tttacaaatg cgataaaaag gcaggccgag 853561 gcttgtcttt ttgcctatgc atgaaacatt tcttctttct gcacgtaaca atgagaaagg 853621 agatgatgat atgacgggtt tagtcggcgg agggcttatg atcattgcgg gcatactgat 853681 caaactgttt cctcccaaat cgatcaacag tgtgtacgga tacagaacga gacgctcaat 853741 gtcagatcaa agattatgga atgaagcgaa ccgttacagt gcatcattaa tgatcctgtc 853801 aggcttggtg attgcgggaa tgggtttgct gctgggatca aacttgttta ttcttcagct 853861 tatcctgctg attgccgcct gtgtcataac atttatgcta acggagaaaa ggctgaaaat 853921 catgacgcac agtcaaggag gagatagaag tggacggagt taaatgccag tttgtcaata 853981 cgaacggaat cacgcttcac gttgcagccg caggacggga agatggcccg ttaattgtcc 854041 tgctccatgg atttcctgag ttttggtacg gctggaaaaa tcaaatcaaa ccgcttgttg 854101 atgcgggtta ccgggtcatt gctcctgatc agcggggcta caatctcagt gacaaaccgg 854161 aaggaattga ttcgtatcgg attgatacat taagagatga tatcatcggg cttattacgc 854221 aattcactga tgaaaaagca attgtcatcg gtcatgactg gggaggagct gtcgcatggc 854281 atttggcttc cacacgcccg gaatatcttg aaaaactgat cgcgatcaat atcccgcacc 854341 cgcacgtcat gaaaaccgta acgccgcttt atccgccgca atggctgaaa agctcgtata 854401 tcgcatactt ccagctgccc gatataccgg aggcatcact aagggaaaat gattatgata 854461 cattagacaa agcgattgga ttatccgacc gtcccgcgct ttttacatcc gaggatgtca 854521 gcaggtacaa agaagcgtgg aagcagccgg gcgcgctgac agctatgctg aactggtaca 854581 gagccctcag aaaaggaagc ttggcagaga aaccctctta cgaaacagta ccttaccgaa 854641 tgatctgggg aatggaagac cgctttttga gcagaaagct tgcgaaagag acggaaaggc 854701 attgcccgaa tggacatctc atctttgttg atgaagcttc ccattggatt aaccacgaaa 854761 agccagccat cgtcaatcag ctgattttgg aatatcttaa gaaccaataa gctaaaattt 854821 ctctccatcc gtctgtcata atggcagact ttttctgtgc gttttttttc atagtctgtt 854881 ttaaacatga caaaataaca ttaaaaatca tgaatgtcac cataaaattg taacaaaaaa 854941 caggtttaaa cgactttaaa aaaaggaata gccttactga agatttgtgt aaaactcccc 855001 taaggcaata cttaaaaaga ataataaaaa gaaggtgcct taatgaagca aggattaatc 855061 tcgattatta tcccgtctta caatgaaggg tataatgtta aactcattca tgaatcttta 855121 aaaaaggaat ttaaaaacat tcattatgac tatgaaatat tcttcataaa cgacggaagt 855181 gttgatgaca cgcttcagca gatcaaagac ttggcagcga cgtgcagccg ggtaaaatat 855241 atatcttttt ctcgaaactt tggaaaagaa gccgcaattt tggcgggctt tgagcatgtt 855301 cagggcgagg cggttattgt catggatgcc gatctgcagc atccgacata tttgctgaag 855361 gaatttatca aaggctacga agaagggtat gaccaagtca ttgcccaaag gaacagaaaa 855421 ggggacagct ttgtccgctc actcttatca tctatgtatt acaagttcat taataaagcg 855481 gtggaagtcg atttgcgtga cggtgtcggt gacttcagat tgttaagccg ccaagctgtg 855541 aatgcacttt tgaagctgag cgaaggaaac cgcttctcaa aaggcctttt ttgctggatt 855601 ggctttgatc agaaaattgt attttatgaa aatgtcgaac gaaaaaacgg cacctccaaa 855661 tggtcgttca gcagtctgtt taactacgga atggacggcg tcgtttcatt taatcataag 855721 ccgctgagat tatgttttta tacaggcatt ttcatcctgc tgctttccat catttatatc 855781 attgccacat tcgttaaaat tctgactaac ggtatttctg tgcctgggta tttcaccatt 855841 atctcagcag tgttatttct cggcggagta cagctgttaa gtcttggaat aataggtgaa 855901 tatatcggcc gaatctatta tgaaacaaaa aaacgcccgc attatttgat caaagaggcg 855961 aatatcccga acaaagacct gcctgaaacg aacgaattaa aaagcatgcg gcgtctgaca 856021 aaaatgcact gaaaatacca agcgccattg gcagtgcttt ttttgcgtgt ctattatctt 856081 aaaagcaaga ctggagaatt catatgaaaa gaaaacatat catgatctat gcggccagtt 856141 tgctggtgtc cgttctggca cacgcttttt ttgtgaaaga atgggcggaa ggcaggtata 856201 tgacaggtcc gggtgacggg cttgcgcaaa tgatcgtatt taaaaaatta ttatttgacc 856261 aatatacaca cgggaatttt ttctacaatt attcattcgg acttggcggc ggcacattca 856321 gtcagctcgg ctattatttt tctgcgtctt ttctttttct tgctgtgtct gccgctgttt 856381 ggctgcttca agccgtccag ctgatcggag aaacggatac gcttttttgg gcagagtcag 856441 ctgtttttat cagtattttc aaattgagct tgatcatctt tacgtccgct tctgtttttc 856501 attatcttct taagcacagg gcggcatcgt tcacgggagc cgtgttatac ggcgtctcaa 856561 ttatttattt ccgtcacgaa gcgtattggg aatttttcac cgatacaatg gtttggcttc 856621 cgctgcttgt gcttggcgca gaaaaaatta ttagagagcg gcgtccggcg tggtttatcg 856681 ttgcgtgttc gctgacgtta atcaacaatt tttactttgc atacataaac cttatattca 856741 tcggaatcta tgtgctgttc agatggctga tccgtttgga accacatgaa gagaaaagat 856801 ggattcaaat cagattattt ctcgtttcag gcttcatttc ttttggcatc agtgcggcgg 856861 cgtttgtgcc ggtagtatac ggttttttaa acaacctgcg ccctccatac agccagaaaa 856921 tagagtggct caatttcgat gataatatct tattttcgag ccggatcatc attgtgccgg 856981 ccgcttttct gctgtttttg tttattattt ctttttacaa aaaccgtgtg tttcgtctct 857041 ttgccgggtt gagcctgctg tttattctgt ttcatttcag tccgtatgcg gcaagcgtct 857101 ttaacggttt ttccgccccg caaaaccggt ttgaatatgt tctggccttt accattgcgg 857161 gagcagctgc ggctggtttg tcacagctgt ctgaattgaa acggaaagaa ctgctcccgg 857221 ccgcagctgt cgtcctgctt ctttacttgt atcatatcca aaggtataag ctcgatatat 857281 ggaagcctgc gaatgaaagt attctattgc tcttactcat gacaatcgca gccttgtttg 857341 ctgcagcttt tgcgaaaaaa cgggcaaaaa tggctgtgta cggtataatc attctttctt 857401 cgctgtttgt cgccaactcc tatcaaaaat acgcgctctc agaaggcggc gatttggaca 857461 gtgtgacaaa agaatatctt acaagtgagg aatacagagg gcgggaatca tctgagctca 857521 tcagacgttt acagaaggaa gacgatgacc cgctcatgag aatcgactgg atgaacgggg 857581 tccgcaataa tacgccaatc atttacggat ttaatggctt cagcgcgtat tccagcattt 857641 taaacaaaga tctgctggcc ttctattgga atgatttaag catcgatatg ggcagggaaa 857701 gcgtcagccg ttacgcgtca ttgggagaca gggcgaattt atacagcctg ctttacggca 857761 aatattatat gaccgaaaaa acaaacgaag ccagcgtccc gtacggcttc aaaaagcatt 857821 tagaaacaga gcattatgca gtttatgaga atcagtacat gcttccattc gttaaaacag 857881 cggatgccat atacagcgaa agtgagctgg accgattgcc cgctcttgcg aaagaacagg 857941 cgatgctgaa aggaattata ttaaaagatc catcaggaaa aacggagcag acaccaaaac 858001 cgtccaattt gatcaccaag tcggacatca ccgcaaaaca agcccagtat caaaacgggc 858061 tgctaaccgt aactggagaa aacggaggag agctgatcat caccccgaaa cagccatcat 858121 ccgctccggg agactactat gtcagctttt atttgaaaag caaagcaaaa gacaaaggat 858181 ttacattaaa ggtaaatgat tatgtcacaa caaggaaatc gaacaaatcg atctataaaa 858241 ccggagtaaa taatataacg gtaagagtgc ctaaatcagg ccatatctca atcaatcttc 858301 cgaaaggaac ctatgagctg agaaacatag cgctctatga agaaaattac caaacgctga 858361 aaaacgctgt aatgcaaaat aaaacagaga aagcagacaa actgaattgg aacaaaaatc 858421 gactgacctt ttcctatcat ctgtcaaaag accagtacat catgcttccg atcccatatg 858481 aaaaaggctg ggagctgaag atcaacggaa aaacacagaa gatcgaaaaa gcggattatg 858541 cttttatagg cttcaaggcg caaaagggag acaatcacat tgagctgact tactatccgc 858601 catacttcaa aatatcggcg atcatatctc tcgtcagtct gctgcttgct gttttttata 858661 taagacgtaa aaagcccggc tctatataga gccgagcttt aattttttct gaagtttttc 858721 ttcgctgaat atccatcccg tataggatga acgaatcgtg agatcatggc cgatatgaac 858781 aattgcgaca aacggataat ggcctttgct ccgataacgc aggtcgataa atctcacctc 858841 ataatgatct ttaaacgtat ccacttccca ccggtatacc ggagaaaagg acagaaacgc 858901 cgcgatgtta tcatcctgct ttgccgcatg cattacatcg gtttcaggaa caggcacccg 858961 attaaatgta tccagaatca cgacatgtcc ttccatgctt cttcctacat agaaagcatg 859021 tgctgtcgtc actgcgattc gccattgcct gaatttcatc gttggagaaa taataatgct 859081 ttcgatctca tcatgaatca tctcatgaag cttccgttta attctcagct gcatgatcag 859141 gcgcaccaag tagtagccta ccaatatgat atataagctg agaaacgtga tgccgggact 859201 cccgcctgca taccaaatcg cgatagctgc cagatggctg ataaaaataa acggatcaaa 859261 cgtattaatc agcccgagcg caacccattt tttcgaaaac ggacgaatgg cttgtgttcc 859321 ataggcgttg aatatatcaa caaagacatg cagaacgact gccagcagtg tccacagcca 859381 caggtgcaga aaatcggcct gaggataaaa taaatacaga atcgccggga tgatgacaga 859441 ccaaaacaaa acggcgggaa ttgaatgggt aaatcctctg tgattcctta tataaacagc 859501 attgttttta agctttaaca cagtatcaat atccggagcc tgagagcccg caagcgttgc 859561 gatcataaca gcgtgagcca ttgccggatc tgatccgaca acaggatcaa gcgtcgcaat 859621 accgcccagt gcgatgccca taacgacatg tgtgcccgta tccataggtg acctccttgc 859681 agggtgatcc tgcacattca ctttgtaaga aattccccat tttcatatac ccaattttta 859741 aactgattca atcgttctca tatgtttccg ctttttcttt attactattt aatgtaacat 859801 attatcgtac tgtgccctta gtgtacaaca aaaaacagtc taaagaaaag cggggcgcga 859861 aagactgggg agaaacacat atgaacgtac ttgaagacaa attaaaacaa aaagacatac 859921 agcaatttcg cgatgattta atctcatggt ttgaacgaga gcagcgcgtt ttgccgtgga 859981 gagaggacca agatccatat aaggtgtggg tatctgaagt gatgctgcag caaacgagag 860041 tagagacagt gattccttac tttctccggt ttgtagaaca attcccgaca gtggaagcgc 860101 tcgctgatgc tgatgaagaa aaggtgctga aagcatggga agggctcggc tattattcgc 860161 gagtcagaaa cctgcaaagc gcggtaaaag aagtgaaaca ggaatacggc ggcattgttc 860221 ctccagacga gaaagatttt ggcgggttaa aaggcgtcgg cccttataca aagggagcgg 860281 tgctcagcat tgcctacaat aaacccattc ccgcggttga cggaaatgtg atgcgtgtca 860341 tgtccaggat tctatctatt tgggatgata ttgccaaacc aaaaacaaga acgatctttg 860401 aagacgccat acgagctttt atttccaaag aaaaaccatc tgaatttaat cagggcttga 860461 tggagcttgg agccttgatc tgtacgccaa aatcaccctc atgcctgctt tgcccggttc 860521 agcagcattg ctcagcattt gaagaaggca ctgaacggga gcttccggta aaaagcaaaa 860581 agaaaaagcc cgggatcaaa accatggccg cgatcgtact gactgatgaa gacggacaag 860641 tgtatatcca caaacggccg tctaaaggtt tgctcgccaa cctgtgggaa ttcccgaatc 860701 ttgaaacaca aaaagggatc aaaactgagc gtgaacagct cattgctttc ttagaaaacg 860761 aatatggcat acaagctgat atcagtgatc tgcaaggtgt agtcgagcat gttttcaccc 860821 acctggtatg gaatatttca gtgtttttcg gtaaagtaaa acaagtgtcg gataccagca 860881 agctgaaaaa agtaacgaaa gaagagctcg aacaatttgc gttcccggtg tcacatcaaa 860941 aaatctggaa gatggcagga gaagcagccg ccatctcggc tgctccgtaa accattctta 861001 atcgtaagag acgcgcgtgc cgtggctgta gtccgcttca ttgcgcttca ttccgccgcg 861061 cgcttcaatt tcttgcgtta attcccggta ttttgattgg ccttcttcgt tcaaataagg 861121 cataatttgc tgaaaggcat gatgaaaata agcgagttca ctgttcttcc aatctttttt 861181 ggaaaccatg ttcaattcgc tcatatcacg tccgacatac ataacagaag acccccttta 861241 aagttcttgc cattattgtt tgtggaaata aaagaactat acgctacaag gagatgagga 861301 aaaatggaac aaaataaatg tgcactcgta acaggaagca gccgcggtgt cggaaaagcg 861361 gccgcgatca gacttgctga gaacggctat aacatcgtca ttaactatgc acgcagcaaa 861421 aaagcagcat tagaaacagc ggaagaaatc gaaaagcttg gcgttaaagt gcttgtcgta 861481 aaagcaaacg taggacagcc tgcaaaaatc aaagaaatgt ttcagcaaat tgatgaaacg 861541 ttcggcagac ttgatgtttt tgtcaataat gccgcttcag gagtactaag acctgtcatg 861601 gaattagaag aaacacactg ggactggacg atgaacatta atgcgaaagc attgcttttc 861661 tgcgctcagg aagctgccaa gctaatggag aagaacggtg gcgggcatat tgtcagcatt 861721 agttcattag gctctatccg ctatcttgaa aactacacca cggtcggtgt atcaaaagca 861781 gcgttagagg ctttaacccg ttatcttgcc gttgagcttt caccaaaaca aattatcgtc 861841 aatgctgttt caggcggagc gatcgacaca gatgcgctga agcacttccc gaatagagaa 861901 gatctgcttg aggatgcgcg ccaaaatacg ccggcgggac gcatggtcga aattaaagac 861961 atggttgata ctgtggagtt tctagtgtct tccaaggctg acatgatccg cggacagaca 862021 attatcgttg acggcggacg ctcactgctc gtttaaaaat ttttaaaaaa gaggaatagc 862081 tatacgatca cctgcacatt ctaatgaccg tggaggtgat aacaatggct aactcaaata 862141 acttcagcaa aacaaacgct caacaagtta gaaaacaaaa ccaacaatca gctgctggtc 862201 aaggtcaatt tggcactgaa tttgctagcg aaacaaacgc tcagcaagtc agaaaacaaa 862261 accagcaatc agctggacaa caaggtcaat tcggcactga attcgctagt gaaactgacg 862321 cacagcaggt aagacagcaa aaccaatctg ctgaacaaaa caaacaacaa aacagctaat 862381 cactgaaaca gaaaaaagca cttcatcttc gggtggaagt gcttttttct gtttgaaaaa 862441 cgacaaaact tgtggaaggt ctacagaatg agtcaaaggg tttgctttat ggagatcgaa 862501 atgattaaag gaggaaatgt ttatactttc atcaggctga aggaggaacc gatgaccgaa 862561 tttgaaaagc tggtaagtga acagatgaaa acgatggata agcttctcga tctccaatca 862621 gagctcgacc gctgcaaaca aattgaggcg gaactccggc atttggaaag ggatgcaagg 862681 ctgcgtggga ttcaggctga aattgcggta aaacggaaac accttgccga tatacaggat 862741 atgtttcaaa agcagacaga gcaggtcatt cgttcatatc gcagctcaga aaagccgtct 862801 tcctttgtgt agtgcaggaa tgtgccattc cccggccgga atggctcttt tattttcatt 862861 tttcaatttg taacgttata ataggtaaaa gacgttgtcg gtaagcaaat ttggacatac 862921 taactgtagg gctttataga aagtagggga gaaatatggg ctatcccaag gaaggagaaa 862981 ccattcaaat tcacagctat aagcacaacg ggctgattca tagaatttgg aatgagacaa 863041 caatcttaaa aagtacagaa atgtgtgtca tcggagccaa tgaccggacg atggtaaccg 863101 aatcagacgg ccggacatgg ataaccagag agcccgcaat ctgttatttt cacgcaagac 863161 aatggtttaa tgtcatcggg atgctgaggg aagacggggt tcattattat tgcaacatca 863221 gttctccgtt tgcctatgat ggcgaagcaa ttaaatatat tgattatgac ttagatgtta 863281 aggtttttcc tgacatgacc tacaatattc tcgatgaaga cgaatatgat gatcatcgga 863341 aagccatgaa ttatccaaaa gaaatcgaca gtattttaag agactactta aatacgctgc 863401 tccattggat tcaccagcgt cagggaccgt ttgcgcccga gtttgtcgat atgtggtatg 863461 aacggtattt gcgctataca aaataatggt tacgtaaaaa cctgttgcgg ggtacaacag 863521 gtttttcaca tgggctcaca cacatcatga taaagagaga gggggaatca accgtggggg 863581 ttatgaaacg ctacatgcaa ttcgtcaaac cttataagaa gcaaattttc gttacagtgt 863641 taatcgggat cgtaaaattc tccattccgc ttgctctccc attgcttctg aagtacgtag 863701 ttgacgacat tattcaagga ggcggcacgg ccagtgacaa aaccacgtca ttgttcacga 863761 ttatggcgat catgttcgcc ttatttttaa ttttgcgccc gcctgttgaa tattaccggc 863821 aatattttgc ccagtggact gccagcaagg tgctttatga tataagagct aagctgtttg 863881 accatataca aaaactgagc cttcgttttt acgcgaatac aagaacaggg gaagtcattt 863941 cccgagtgat taatgatgta gaacaaacaa aggatttcgt catcacaggg ctgatgaata 864001 tatggctcga tatgctgacg attttgattg taatctctat catgctcaca ctggacgtta 864061 aattaacgct gatctctatc gttttattcc cattatacgg aatatcagtg aagtattttt 864121 acggccgttt acgaaagctg acaagggagc gctcacaggc tcttgctcaa gtgcaggggc 864181 atttgcatga acgcattcaa ggcatgcctg tcatcagaag ctttgcgata gaagatcatg 864241 aacaggctca atttaatgag aaaaacggtc atttcttaga taaagccatc cgccacacga 864301 attggaacgc gaaaaccttt gcggtcgtta ataccattac agatttggcg ccgctcatcg 864361 tcatagcgtg cgccgggtat tttgtcatta atggaccgct gacagtcgga acaatggtcg 864421 cgtttgtcgg atatattgac agaatgtaca accctgttag aaggctgatc aattcctcta 864481 caactttgac acagtcaatc gcatcaatgg acagggtgtt tgaatttatt gacgagccct 864541 atgaactcac tgacaaacca aatgcgataa aggccgatca gattcgcgga ggagtggagt 864601 ttcaaaacgt ttcgtttcaa tatgagaagg acaaagaaaa tattcttcat gatgtatcct 864661 taaaagtaaa tagaggagaa actgtagctc tcgtcggcat gagcggagga ggaaaatcaa 864721 cgctcgtcag cctgatccca agattttatg atgtaacaag cggcagactg ctgattgatg 864781 ggacggatat tcgcgattat gaagcaagaa gccttcgcaa ccaggttggt atggtgcttc 864841 aagatacctt tttatttagt gaaacgattc gggaaaatat cgcgatcggc aagcctgatg 864901 ccacacttga agagataatc gaagccgcca aagctgcaaa tgcccatgaa tttatcatga 864961 gttttccaga aggatatgag acccgggtgg gggaacgagg cgttaagctt tcaggcggac 865021 aaaagcagcg gatctcaatt gcgcgggtat tcctgaaaaa tccgccgctc ctcattttag 865081 atgaagctac atcagctctg gatttggaaa gtgagcatta cattcaagaa gcgatggaca 865141 aactggcgaa ggatagaaca acttttgttg tcgcccaccg tttatcgaca atcacccatg 865201 cggataagat tgttgtcatg gaaaacggga caatcattga aatcggaacc catgatgaac 865261 tcatggacta tgagagccaa tacaagcact tatttaccat tcaaaatttg aactaaaaca 865321 tcaatcttat atccttttaa cgaaggatat aagatttttt tgtatataaa aaaacccggc 865381 tgtttaaccg ggttactctt ctgtttctat ttcgcagtct ttcggatgat acgtttgaaa 865441 acttgtgata agtgtttcta aatgttcaag ctgctcgcga tattccacgg cgcttgccat 865501 aatattgagc atgttgtaat caataagctc ctcatccgta ttctgctgat tttttaaaaa 865561 tgactttgtt aaaagctgct tataccggat gccttcttca accgcgtcat catgcggctt 865621 gatttttccg acaaacctca tcaaaatccg ctcgtgccag taaagcaggt aatcaagttc 865681 ttcagtcaat gtttcctgaa actcttccgg catatgatag atctcgtttt ccagacgatg 865741 cagcttcttc aatgtatcaa gcgcccgatt tgcagtaata atggcctgtc tgaacaggac 865801 aagctttctt gatttcacat aagtcgtttt cttaaagtaa cttctttctt ctttatatag 865861 aagatatgtc tgatcaagct tgatcatttt ttctttcagt ttttcaatat cctctttcaa 865921 aatcgaatgc tctgtcgact gccgcatgga caatctgatc cacttcataa tttcttcggt 865981 gttttcgacg gtattatgaa tcagctttgt ttcgtactta ggaggcaaaa acacaaggtt 866041 gacgataaag gaagaaagca cccctaagat gactgtgctt gttctgatca gcgcgaacat 866101 taaaaagtcg tcaccggcag attctaatat cgcaatgact gttacaagag caattgaaat 866161 tgtatgttca attttaagtt tcagcatgat tgtaatgaca ataactgctg ttaacccgat 866221 cataatcggg ctgggtccga aaataaggcc gaacactgtg gcaatcacag ctccgatgat 866281 atttgcttga acctggtcaa taataatgag aaaagagcgg taaatcgacg gctggatcgc 866341 aaatatcgct gcaattccag cgaaaatcgg cgcgggaagc ccgatccacg aagccaaata 866401 aagggcaagt gtaatcgcaa tcccggtttt gaaaatgcgg gcaccaagtt tcattggttt 866461 gtgcgtgcat tcctttctat agtaaattgt gtgacatagc aaatgggcta atccttaaaa 866521 ttcccggtta gtttatttgc taaacaatta agtaatatac agggatcgat acaaatattc 866581 aagctatttt tctagaaaaa gaccaaaatc ttacacgctg tttgattcca taaaaaaaca 866641 ggagctcaaa gctcctgttc aaggtatttg attctagttt tttagatgtt taaatgcatc 866701 ctcgaccgct gtaagcgtgt ctttaatatc ctgctctgta tgtgctgtgg taataaacca 866761 agcttcatac ttagaaggtg ctaaattaat tccgcgttcc agcatcagct tgaaaaacgt 866821 agagaatgtt tctccgtcac tccgttcagc ctgctcgtaa ttttccactt tctcatcaga 866881 gaagtatacc gtgagcgcac cttttaaccg gttgaccgta atggtgatgc cgtgtgtttc 866941 tgcgtgcttc aaaatgcctt cctcaagcat agcgccaagg tgatcaagct tttcatacac 867001 gcctttttct ttgagcactt ccagacaagc gatgcctgat aggatggaag cggggttccc 867061 tgccattgtt cctgcctgat aagcaggccc tagcggagct acctgctcca tgatttcttg 867121 tttgccgcca taggccccaa tcggaagtcc gccgccgata attttcccga gtgctgttaa 867181 atctggtttc acctgtaaga gatcctgcgc gccgccatac ataaagcgga aagccgtaat 867241 gacttcatcg taaataacga gagcccctgc attatgtgtt aattcattta cttgttctaa 867301 gaagccctct ttcggctcca cgataccgaa gttgccgaca atcggttcaa cgagaaccgc 867361 cgcgatttca ctgccccatt tttcaagagc tgctttatag ctatcgatat cattaaatgg 867421 tactgtgatc acttcgtttg caatgctttt cggtacaccg gctgagtctg gtgtgccgag 867481 agtagacggg ccggagcctg cggcgacaag cacaaggtcc gaatgcccgt gatagcagcc 867541 cgcaaattta atgatttttg tccggcctgt atatgcgcga gccacgcgga tggtcgtcat 867601 aacggcttct gtacccgaat tgacgaatct tactttgtcc atagcgggaa tggcttcttt 867661 gagcattttt gcaaatgtaa cctcgtgttt cgttggtgtt ccatacaata caccgttctc 867721 tgctgctttt ttaatcgctt ctgtaatatg cggatgggca tgtcctgtaa taatcggacc 867781 gtacgccgct aaataatcga tgtatttgtt gccgtccaca tcccaaaaat aagcgccgct 867841 tgctttctcc attgcaacag gagaaccgcc gccgactgct ttatatgatc tagacgggct 867901 gtttacaccg ccgacaatgt gctgtaatgc ctcattgtga agttcaattg attttgtatg 867961 caagaataaa aacctcctat atctccatgc gtcctttcta ttgtagcatg cttccgaaca 868021 agaacaatgg cttcgggctt cagattcagc tgagatggtt gtaatctgga caagaattgg 868081 atacgcttaa taaaaaaaca tccggaggta acgtaatgac tatagaaatc ggacaaaaag 868141 cgcctgatct tgagttaaaa ggtgatcatg gggaaacagt aaaattatcg gattataaag 868201 gaaagtacat cgtgctttat ttttatccaa aggacatgac accgggatgt acaactgaag 868261 catgcgattt tcgggacagt cacgaaagct tcgccgaact ggatgccgtc attatcggcg 868321 tcagcccgga cagccaggaa aaacacggaa aatttaaaga gaagcataac cttccatttc 868381 tgcttcttgt tgatgacgag cataagctgg cggaagcatt tgatgtgtgg aagctgaaga 868441 aaaacttcgg aaaagagtat atgggaatcg agcgttccac ttttttaatt gataaagaag 868501 gccggctcat taaagaatgg agaaaagtaa aagtaaagga ccatgtagcc gaagcgcttc 868561 aaaccctcaa agatatgtct gaaaagtaaa tctctatgag cctatgctta cttttaccct 868621 gatatcaatt gacaaattat cgtagaaaga gttacactaa ttataaacat tacaatgtaa 868681 gaattttttt tagaagagag gtgcatgacg gatggctgca catgaactaa aagaagcctt 868741 agaaacgttg aaggaaaccg gagttcgcat tactcctcaa cgtcatgcga ttctggaata 868801 tctcgttaac tctatggctc atccaacagc ggacgatata tataaagctc tggaagggaa 868861 atttcctaac atgagcgtag cgacggtata taacaatttg cgtgtgttcc gggaatcagg 868921 tttggtaaaa gagctcacat acggtgatgc ttccagcaga ttcgattttg tcacatccga 868981 tcactatcac gcgatttgcg aaaactgcgg taaaattgtg gacttccact acccgggcct 869041 tgatgaagtg gagcagctcg ctgcccacgt cacgggcttc aaggtaagcc accaccgttt 869101 agaaatttac ggcgtctgcc aagagtgttc gaaaaaagaa aatcattaaa aataagctga 869161 ccgcacgaaa cggtcagctt attttatttc gacattttct ttttattata agactcatca 869221 aattcttttc cttctaatcc cttatctaaa gtcagcggct ctcggcaatg catgcacata 869281 tcgactactc ctaaaacctt tgtctcttta tcacagcctg gacaaatgac gcgaaccgct 869341 ttagtcgaaa gcattccgat ccaaaagtaa actaccgtgc tgagaccgat ggataaaagc 869401 ccaagtatca taaacaaact agaaagcaaa actgactctt tgaaaaagat cccgatgtac 869461 ataatgataa acccaacgaa aaccaaactt aacgcaaatg ttctgatttt attaattttg 869521 ctggagtatt tcgccatgtc catccccctc tgttttaact atagcacaaa cccgatggga 869581 ttttcttcat gttttcggtt gaactggaat ttacatatgg agagttactg tgaaattgtt 869641 tataatagtt caatgtgttt agaaaaaagg aatttcgttt taaccataga attgaatcaa 869701 atagagaata aaaaaatttg aacaattgca ttggaggaat agtgatggaa aatcttctcc 869761 gtccaattta ccaagaaaga gcaagtcacc ccaatacatt ggctgtcatt atgattgaga 869821 gaagaaacaa aacatcttcc ttaacagata actttgatgc agctttgctg gtgattgtaa 869881 aggatgctga tgagccagtt tttataaagc attatgaatt tgatcatcaa acagcttctt 869941 tgcatgtggt aacagattct cagattcaag aatggatttt gcttggaaca aatagaagaa 870001 tcatagattg gattgtaaat ggcagagtct tgtttgaccg taatgaatac gtagttgaac 870061 tgattgacag gctgaataca tttccgtttg ccgaacgtaa actgaagatc ggactcgaat 870121 acggcaaatt aatcagaagg tatgttgaag ggaaagcttt ttttgaagcc aatcaatttt 870181 tagatgccta caatgccgtt gttcatgcgc tgcatcattt agcacgtatt gaagtaatcg 870241 acagaggatt ccatcccgaa accacggtgt ggagccaagt gcgccagatg gagccccaag 870301 tgtacaaatt atattccgag ctgattgaaa gtcatgagag cctggaaaaa agacttgaat 870361 tattattctt agcaaatgat tttctcatcc attccaaagc cgagatcggt tcggcgcatc 870421 ttttcgaagt aatgaaagaa aaagacattt ggcaattcgg tgagcttctt caacatcatg 870481 acctaaagca ctttacccaa gatcttggcg ttatgcttga ttacttgacg gaaaagggac 870541 ttatcaacgt ctgccagata gaaacgaaag gacaggctgt ctatcaccga ggatattctt 870601 ttaaaaaagg tgttgactct gattcttgac cgtgttatat tattaaacgt cgctgatgcg 870661 cttctgagaa aacaagctca cagcggcggg aaaataaatc aaaaaaacat ttgacaaaag 870721 aaagtcaaaa tgttatatta ataaagtcgc ttcaacaaga agtgaaaatg atctttgaaa 870781 actaaacaag acaaaacgta cctgttaatt cagtttttaa aaaatcgcac agcgatgtgc 870841 gtagtcagtc aaactagggc ctgcacgacg caggtcacac aggtgtcgcc gcaggatgcg 870901 gtgaacttaa cctgtgatcc atttatcgga gagtttgatc ctggctcagg acgaacgctg 870961 gcggcgtgcc taatacatgc aagtcgagcg gacagatggg agcttgctcc ctgatgttag 871021 cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa gactgggata actccgggaa 871081 accggggcta ataccggatg gttgtttgaa ccgcatggtt caaacataaa aggtggcttc 871141 ggctaccact tacagatgga cccgcggcgc attagctagt tggtgaggta acggctcacc 871201 aaggcaacga tgcgtagccg acctgagagg gtgatcggcc acactgggac tgagacacgg 871261 cccagactcc tacgggaggc agcagtaggg aatcttccgc aatggacgaa agtctgacgg 871321 agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa gctctgttgt tagggaagaa 871381 caagtaccgt tcgaataggg cggtaccttg acggtaccta accagaaagc cacggctaac 871441 tacgtgccag cagccgcggt aatacgtagg tggcaagcgt tgtccggaat tattgggcgt 871501 aaagggctcg caggcggttt cttaagtctg atgtgaaagc ccccggctca accggggagg 871561 gtcattggaa actggggaac ttgagtgcag aagaggagag tggaattcca cgtgtagcgg 871621 tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg cgactctctg gtctgtaact 871681 gacgctgagg agcgaaagcg tggggagcga acaggattag ataccctggt agtccacgcc 871741 gtaaacgatg agtgctaagt gttagggggt ttccgcccct tagtgctgca gctaacgcat 871801 taagcactcc gcctggggag tacggtcgca agactgaaac tcaaaggaat tgacgggggc 871861 ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac gcgaagaacc ttaccaggtc 871921 ttgacatcct ctgacaatcc tagagatagg acgtcccctt cgggggcaga gtgacaggtg 871981 gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc aacgagcgca 872041 acccttgatc ttagttgcca gcattcagtt gggcactcta aggtgactgc cggtgacaaa 872101 ccggaggaag gtggggatga cgtcaaatca tcatgcccct tatgacctgg gctacacacg 872161 tgctacaatg gacagaacaa agggcagcga aaccgcgagg ttaagccaat cccacaaatc 872221 tgttctcagt tcggatcgca gtctgcaact cgactgcgtg aagctggaat cgctagtaat 872281 cgcggatcag catgccgcgg tgaatacgtt cccgggcctt gtacacaccg cccgtcacac 872341 cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt ttaggagcca gccgccgaag 872401 gtgggacaga tgattggggt gaagtcgtaa caaggtagcc gtatcggaag gtgcggctgg 872461 atcacctcct ttctaaggat attatacgga atataagacc ttgggtctta taaacagaac 872521 gttccctgtc ttgtttagtt ttgaaggatc attccttcga aacgtgttct ttgaaaacta 872581 gataacagta gacatcacat tcaattagta atacaagata tcacatagtg attcttttta 872641 acggttaagt tagaaagggc gcacggtgga tgccttggca ctaggagccg atgaaggacg 872701 ggacgaacac cgatatgctt cggggagctg taagcaagct ttgatccgga gatttccgaa 872761 tggggaaacc caccactcgt aatggagtgg tatccatatc tgaattcata ggatatgaga 872821 aggcagaccc ggggaactga aacatctaag tacccggagg aagagaaagc aaatgcgatt 872881 ccctgagtag cggcgagcga aacgggatta gcccaaacca agaggcttgc ctcttggggt 872941 tgtaggacac tctgtacgga gttacaaaag aacgaggtag atgaagaggt ctggaaaggc 873001 ccgccatagg aggtaacagc cctgtagtca aaacttcgtt ctctcctgag tggatcctga 873061 gtacggcgga acacgtgaaa ttccgtcgga atccgggagg accatctccc aaggctaaat 873121 actccctagt gaccgatagt gaaccagtac cgtgagggaa aggtgaaaag caccccggaa 873181 ggggagtgaa agagatcctg aaaccgtgtg cctacaagta gtcagagccc gttaacgggt 873241 gatggcgtgc cttttgtaga atgaaccggc gagttacgat cccgtgcaag gttaagcaga 873301 agatgcggag ccgcagcgaa agcgagtctg aatagggcgc atgagtacgt ggtcgtagac 873361 ccgaaaccag gtgatctacc catgtccagg gtgaagttca ggtaacactg aatggaggcc 873421 cgaacccacg cacgttgaaa agtgcgggga tgaggtgtgg gtaggggtga aatgccaatc 873481 gaacctggag atagctggtt ctctccgaaa tagctttagg gctagcctca aggtaagagt 873541 cttggaggta gagcactgat tggactaggg gcccctaccg ggttaccgaa ttcagtcaaa 873601 ctccgaatgc caatgactta tccttgggag tcagactgcg agtgataaga tccgtagtcg 873661 aaagggaaac agcccagacc gccagctaag gtcccaaagt atacgttaag tggaaaagga 873721 tgtggagttg cttagacaac caggatgttg gcttagaagc agccaccatt taaagagtgc 873781 gtaatagctc actggtcgag tgactctgcg ccgaaaatgt accggggcta aacgtatcac 873841 cgaagctgcg gactgttctt cgaacagtgg taggagagcg ttctaagggc tgtgaagcca 873901 gaccggaagg actggtggag cgcttagaag tgagaatgcc ggtatgagta gcgaaagagg 873961 ggtgagaatc ccctccaccg aatgcctaag gtttcctgag gaaggctcgt ccgctcaggg 874021 ttagtcggga cctaagccga ggccgaaagg cgtaggcgat ggacaacagg ttgatattcc 874081 tgtaccacct cctcaccatt tgagcaatgg ggggacgcag gaggataggg taagcgcggt 874141 attggatatc cgcgtccaag cagttaggct gggaaatagg caaatccgtt tcccataagg 874201 ctgagctgtg atggcgagcg aaatatagta gcgaagttcc tgattccaca ctgccaagaa 874261 aagcctctag cgaggtgaga ggtgcccgta ccgcaaaccg acacaggtag gcgaggagag 874321 aatcctaagg tgatcgagag aactctcgtt aaggaactcg gcaaaatgac cccgtaactt 874381 cgggagaagg ggtgctctgt tagggtgcaa gcccgagaga gccgcagtga ataggcccag 874441 gcgactgttt agcaaaaaca caggtctctg cgaagccgta aggcgaagta taggggctga 874501 cgcctgcccg gtgctggaag gttaagagga gcgcttagcg taagcgaagg tgcgaattga 874561 agccccagta aacggcggcc gtaactataa cggtcctaag gtagcgaaat tccttgtcgg 874621 gtaagttccg acccgcacga aaggcgcaac gatctgggca ctgtctcaac gagagactcg 874681 gtgaaattat agtacctgtg aagatgcagg ttacccgcga caggacggaa agaccccgtg 874741 gagctttact gcagcctgat attgaatgtt ggtacagctt gtacaggata ggtaggagcc 874801 ttggaaaccg gagcgccagc ttcggtggag gcatcggtgg gatactaccc tggctgtatt 874861 gaccttctaa cccgccgccc ttatcgggcg gggagacagt gtcaggtggg cagtttgact 874921 ggggcggtcg cctcctaaaa ggtaacggag gcgcccaaag gttccctcag aatggttgga 874981 aatcattcgc agagtgtaaa ggcacaaggg agcttgactg cgagacctac aagtcgagca 875041 gggacgaaag tcgggcttag tgatccggtg gttccgcatg gaagggccat cgctcaacgg 875101 ataaaagcta ccccggggat aacaggctta tctcccccaa gagtccacat cgacggggag 875161 gtttggcacc tcgatgtcgg ctcatcgcat cctggggctg tagtcggtcc caagggttgg 875221 gctgttcgcc cattaaagcg gtacgcgagc tgggttcaga acgtcgtgag acagttcggt 875281 ccctatccgt cgcgggcgca ggaaatttga gaggagctgt ccttagtacg agaggaccgg 875341 gatggacgca ccgctggtgt accagttgtt ctgccaaggg catcgctggg tagctatgtg 875401 cggacgggat aagtgctgaa agcatctaag catgaagccc ccctcaagat gagatttccc 875461 attccgcaag gaagtaagat ccctgaaaga tgatcaggtt gataggtctg aggtggaagt 875521 gtggcgacac atggagctga cagatactaa tcgatcgagg gcttaaccat atttttgaat 875581 gatgtcacac ctgttatcta gttttgagag aataagtttt tcaaaaaaac acttgatttt 875641 ctcaagaata catagtataa tgttaaatgt cactgaaatt gtctggtgat gatggcgaag 875701 aggtcacacc cgttcccatg ccgaacacgg aagttaagct cttcagcgcc gatggtagtc 875761 gggggtttcc ccctgtgaga gtaggacatc gccaggcaga cttcattccg cagtagctca 875821 gtggtagagc tatcggctgt taaccgatcg gtcgtaggtt cgaatcctac ctgcggagcc 875881 attattggag agctgtccga gtggtcgaag gagcacgatt ggaaatcgtg taggcggtca 875941 actccgtctc aagggttcga atcccttgct ctccgccact gatacttata cataattaca 876001 attgaaagtc tgggcccgtt ggtcaagcgg ttaagacacc gccctttcac ggcggtaaca 876061 cgggttcgaa tcccgtacgg gtcattatat gatggaggat tagctcagct gggagagcat 876121 ctgccttaca agcagagggt cggcggttcg agcccgtcat cctccaccat tatatcatcg 876181 cggggtggag cagttcggta gctcgtcggg ctcataaccc gaaggtcgca ggttcaaatc 876241 ctgcccccgc aaccaaattt taaaatggtc cggtagttca gttggttaga atgcctgcct 876301 gtcacgcagg aggtcgcggg ttcgagtccc gtccggaccg ccatttgaat acttaggctc 876361 ggtagctcag ttggtagagc aacggactga aaatccgtgt gtcggcggtt cgattccgtc 876421 ccgagccacc acctatgccg gtgtagctca attggtagag caactgactt gtaatcagta 876481 ggttgggggt tcaagtcctc ttgccggcac tgttttttca aaatttaatg tggaggggta 876541 gcgaagtggc taaacgcggc ggactgtaaa tccgctccct cagggttcgg cagttcgaat 876601 ctgcccccct ccaccattta taggggcata gtttaacggt agaacagagg tctccaaaac 876661 ctccggtgtg ggttcgattc ctactgcccc tgccaaattt atgacatctt gagattatgg 876721 cggttgtggc gaagtggtta acgcaccaga ttgtggctct ggcactcgtg ggttcgattc 876781 ccatcaatcg ccccatatta tcattgggct atagccaagc ggtaaggcaa cggactttga 876841 ctccgtcatg cgttggttcg aatccagcta gcccagtctc actttttata tcaactgcat 876901 ataatgtatt aagtccatta aaaatgcgga agtagttcag tggtagaaca ccaccttgcc 876961 aaggtggggg tcgcgggttc gaatcccgtc ttccgctcca attacggcgg catagccaag 877021 tggtaaggca gaggtctgca aaacctttat ccccggttcg aatccgggtg tcgccttctt 877081 attgccgggg tggtggaatt ggcagacaca caggacttaa aatcctgcgg taggtgacta 877141 ccgtgccggt tcaagtccgg ccctcggcac caattttact tacatggtaa gttgaattgg 877201 tgtttgtgtt ttatcattat aactaatcat attaatgatc tacataagta gatcattttt 877261 ttaatgcttt gatttatcat aacaagttaa gttccgaggc ctattataaa gcggctgtat 877321 agctagtctt tcaacacttt tattttatat ttccataaaa acttttttga aatacgttga 877381 cactttatga gatccatgat atatttatat tcgtcggtta gatacgacgt aaaacttgcc 877441 ggtgtggcgg aattggcaga cgcgcacgac tcaaaatcgt gttccttctg gagtgtcggt 877501 tcgaccccga ccaccggtat actgaaaaac ccgtttctta acagaaacgg gtttttattt 877561 tttattaaag aaaaggagcc tcggctcctt tttatactta ctcagcgtat tggtctagga 877621 tctcttctag cacctcttct agctcttctg tatcttcaag ctctgattgg ctgaaacgga 877681 cgcgtacaag ctgttctccg tcattataca tctcttccaa ccaccctcgg agtcctcttg 877741 ctctgcggtc gacttcgaaa atgatttcca aaccgtcttc gtctaaaagg aaaatgagct 877801 ctaattcatc aagcatctga cgataatatc cggaagtcgg aacgaattcg aattcttgaa 877861 cgaacggaag acgacgctgg aagtagggcg cttgttcgca gtctgcttcg ttaagacgga 877921 agcccaggtt ttcgattgct tcaagcacat tttcaatcca agggtgcgct tcaacgaaaa 877981 tgcggtcatg atcggattta tcgataccgc cttgaatgtc aaggtctgtc accacggcaa 878041 cctctacttt ccctacagtg atcggcgtat ctagaggcag agtgaatgtg aacggaaatt 878101 gatgctcttc accaggctgt atggtaaatg aaccagtgac ccggaaagaa tgaattgtag 878161 cgtatttccg gtgctcttca tcgtctttta caatgacata ccgtgtgcta agctgtaaat 878221 cgatataacg gatgtcctga gcgatttttc cgcctttgac atgtaccgtt ccctgtactt 878281 cttctcctgg aaaatatgcg tctttttcta aaattgtatc tacttttgca gctccaattc 878341 cggcacttgc cgcaagcttc ttaaaaaatg acatgttaga tcttcccctt tttctttttt 878401 ctcaacagat atacgtaaga aggaggaaaa aagattcgtt tgattcatac ttttttccta 878461 ttattcgtct cggcctaggg acagactaag aataatattg aaaataaagg agtcgatgga 878521 agtgaataaa gaaagtttgg ttgcagatga attacacaga atgtttttgg ctggtgagct 878581 gcaaatcaca gtagaggagg atataaacaa tatttccgaa aggctgagaa acggcgatct 878641 cagtttagac cgattaagcg gtgaagacgt gtttataaaa gaaacggtaa atgaggcttt 878701 aagaagagtg gagcaataaa aaagagacgg catctcatct ttgagatccc gtctcttttt 878761 gtggtctttg ctgtaagata aaagcgaatc gatttggaat tgctcacccg agccacccct 878821 tttctaacag aagatctgac agttcatcat ggagataaac agctgtatct aattgatcat 878881 gcaatgctct tctgatgtgg ggattttcgg ttgctgttgt tgcgacagtg tatttgttaa 878941 tgctggtttt tattgttgtt aacaaatcaa gaatatcttt gggacaaaga ctttgttcaa 879001 tgggaaacca cctcctttgt ttttttagca gctcctgata agaaagtatt tgactttgtt 879061 tcttgcttct atacaaaatg ctataataag caacaaattt tgttgggggg tgtgatgatg 879121 aagcagatta ttgcgatggg gggcgggggt ttttcgatgg agccggataa tttgtccctc 879181 gatcaatata tcctcaatca atcaaaacga gagcagcctc gtatttgttt tttgccgacg 879241 gcgagcggag attcccaaaa ctatattcag cggttttatc atgcatttca aacattggat 879301 tgcgtgccgt ctcatttatc tttgtttaag ccaccatcat cagatttagt ttcttttgtt 879361 atggaaatgg acgtgattta tgttggcggg ggaaatacgc ggaatttact tgtgttatgg 879421 aaagagtggg ggctggacca tattctcagg gaagcatgga agaacggtgt ggttgtagct 879481 ggaataagtg ccggtgcgat ctgctggttt gaagaagggg tgacagattc agccggaccg 879541 ctgacaagtt tgaaaagttt aggttttttg caagggagct tttgtcccca ttatgacggg 879601 gaaaaggatc ggagaccggc ataccaccag ctgatatcta acaagttctt atgcagtggc 879661 tatgcagcgg atgatggggc tgctctccat ttcataaatg atcagctgtt tcagactgtg 879721 agttcaaggt cgggtgcaaa ggcatatcgg gtgatgatgg ctgaacatga aatagctgaa 879781 atcccgttgc cggtcaaata tttagggtga aattggctga atattatcta tattcctctt 879841 tttttcagat tgattttatg ataagatgag tgcgaaatca atagttactg ggggtgcccg 879901 ctttcgggct gagagagaag gcaagcttct taaccctttg gacctgatct ggttcgtacc 879961 agcgtgggga agtagaggaa ttgtttttgt tattgtcttg ctgggcaata atatgtttct 880021 ttctgactgt aaccgggttc atttatatga atccggtttt ttgtgctggt tatgggcttg 880081 attttgtcct ttcaaacgta gaaaggggaa ggaaaagtaa tgcaaaacaa ttcagtgcag 880141 caagccaaca tttccattat gtcaagtttt tcaggcagca agaaggtata cgtggagggt 880201 tcttcttcgg acatccaagt gccgatgagg gagattgcat tgagtccgac gacgggatcg 880261 ttcggcgaag aggaaaacgc gcctgtgcgt gtctatgata caagcggacc gtatacggac 880321 cctgaagtaa ccattaatat tcaagaagga ttaaagccgc tccgccaaaa atggatcaca 880381 gagcgcggtg acgtggaaga gtatgaaggt cgggctataa aaccagaaga taacggttat 880441 aaaaaagcaa aaccaaacgt aagctatcca ggattaaagc ggaaaccgct gagggcgaag 880501 gcaggtcaaa atgtcacaca aatgcactat gcaaaaaagg ggatcattac acctgagatg 880561 gaatttatcg ccattcgtga gcatgtgtct cctgaattcg tcagagacga ggtagccagc 880621 ggccgggcga ttattccttc aaacattaat caccctgaaa gtgagccaat gattatcggc 880681 cggaattttc atgtgaagat taatgcaaat atcgggaatt cagcggttac gtcatccatt 880741 gaagaagaag tggaaaaaat gacgtgggcc atccgctggg gagcggatac gatgatggat 880801 ctctctaccg gaaaagatat tcatacgacg cgtgaatgga ttatccgcaa ttgccccgtg 880861 cctgtgggaa ctgttccgat ttatcaggcg cttgaaaaag taaacggcgt agctgaggat 880921 ttaacgtggg agatttatcg tgatacgcta atcgagcagg cagagcaggg agtggattat 880981 tttacgattc acgcgggtgt tttgcttagg tatgtaccgc tgactgccaa acggacaact 881041 ggtatcgtgt cacgcggggg agcgattatg gcgcagtggt gtctggctca tcatcaagaa 881101 agctttttat acacacattt tgaagaaata tgtgagatta tgaaaatgta tgatattgct 881161 ttctctcttg gggatggttt gcgtcccgga tcaattgctg atgccaatga cgaagcgcag 881221 tttgctgaat tagagacgct tggagagctg acgcaaattg cctggaagca tgatgttcag 881281 gtgatgattg agggtcctgg acatgttccg atgcataaaa tcaaagagaa cgtcgataaa 881341 caaatggaca tttgtaaaga agcgcctttt tacacattgg ggccgttgac aacggatatt 881401 gctccgggat atgaccatat tacttcagcg atcggagcgg cgatgatcgg ttggtacggg 881461 acagcaatgc tttgttatgt aacgccgaag gagcatttgg ggctgccaaa ccgtgatgat 881521 gttcgtgaag gagtcattac atataagatc gctgcgcacg ctgcggacct tgcaaaaggg 881581 catcccggag cgcaaatccg ggatgatgcg ttatcgaaag cccgttttga attccgctgg 881641 cgggatcagt ttaatttatc tcttgatccg gagagagccc ttgaatacca tgatgaaacc 881701 ctgcctgctg aaggagcaaa aaccgctcac ttttgttcca tgtgcggtcc gaaattttgc 881761 agcatgagaa tttcacagga tattcgggat tatgcgaaga aaaacgatct cagtgaagca 881821 gaagccataa ataaaggatt aaaagaaaaa gcaaaagagt ttgtcgatac gggaagcaat 881881 ttatatcaat aaaaaaaatg aagatggaga atgctccatc ttcatttttt tagaaaaaca 881941 gagagcgtcg aagcggagga atactctgtt caaagcggaa aacattttct ggatcatatg 882001 tcgttttgac acggcggagt cgttcaacgt tttcgccgta atatgttctt ggccagtttc 882061 tgatttcgat atctggccaa tttacgtagt ctcccatcgt ttctttcgaa agggacgttc 882121 tcagcccctc aatccagcgg acattttgtc ttttttctcc aggggatgtc cagtttgtta 882181 agtattcctg ggcgatgatt gcgtcacgat aataaaatgc cgtttggtcg ggagcgaccc 882241 gtccggctgc cccgccgagt gcttgctgcc agacactggc gttttgattc ggagcgtgct 882301 ctaaaaagtg ttttattgtt gagatcgcac gttctgataa tggcttttca atgaaagagc 882361 cggagcgttt cattttttga ggctgattgc ctcccgggct gttaaaaaag gttaccgctt 882421 caatgaatgg cgttgttttt accattccgc ttgtcggact tcctgctttc aataaaggct 882481 ttaacagttt ttttaactct gtttttggcc cgacaaattg gccgagggct tctatgcggt 882541 ttacttcttt aggccaaaac tctattgatg atgtaagccg gtcatctgta tacggggccc 882601 agttctgcca cgtgttatat acttcctcaa aatcatccca tccccatgta atagaaaaaa 882661 tcgacacttg agagatgggc actgctttaa atgtcatgga ggtgactatg ccgaaattgc 882721 ctcctccgcc tccctgagac gcccaaaata agtctggatg atttgaacag ctgactgtaa 882781 tcagatcagc gccctctttt tcgtctgcta cgatcatctc aagctgcacg aggctgtcgc 882841 aagtaagacc ggcagccctt gttaaaagtc caattccccc tccgagagtt aaacctgtga 882901 gccctacatt agcaatggtg cctgcgggaa gcgtcaggcc gtattgccag agtgtccgat 882961 agacttctcc caattcagcc cccgcttcaa tataggccag ctttttatcc tgattcacag 883021 ttattttttt catctcgctt aaatcaataa caagaccgtt atttaaaagg gaaaagttct 883081 catagctgtg tctgccgcct ctaatacgga aaggcacacg gttttcacgc gcccatttca 883141 gcgcattgag tgcatcctgt ttgttttggc aaaacacaat gatgtcagga tacctttcta 883201 agcttaggtt aatattggtt cttgcttcgt tatagtccgg atcatcccgt gtcacgatac 883261 gtccggtcaa ttttgtcttt tccacactcc cacatctctt tctctcgtat tctagtttct 883321 ctagcttatg cgtcagggga aaagagtgta taaggaaaaa gcggggatgc aatctgatac 883381 agtgtcaaca ccctcaaaaa atagttgaca ggtcggtatt gtatgaatta acatggtcag 883441 tacaaatttt tcaaatttat cgcgctgatc ggaacaccga aggctcttat cgtttagata 883501 agggcctttt ttgtatgaaa aaggggggat tattgatggg agtcaaaaaa gaaaagggga 883561 gaaaacgatt caggaagcga aaaacctacg ggaatcagat tttgccgctt gagctgctga 883621 ttgaaaaaaa caaacgagag attataaaca gcgcggaact catggaagaa atttatatga 883681 agattgatga gaagcatacg caatgtgtaa ctaaatataa aaaaacccgc tgactacaac 883741 gggtttttgc atttctccat taagaatctt ttttaatcgg caatccaagg ccttctgcca 883801 cgcgttttcc gtattcagga tccgctttgt agaagtgctc gatttggcgc agcttgattt 883861 cttctttttc taccggcttc atggcattaa cgatattttc aacaaggcgg gtacgttcat 883921 cttcactcat taaacgatac agatcgccgg cttgagtgta gtgatcgtag tgatcgtagc 883981 ttacgctgtc agcgatacct tgtaccggat atgctgcttg cttatcctca ggtgactctt 884041 ttggaccgcc gaagctgtta ggctcgtaat acacagatcc gccgccgtta tcatcaaaac 884101 gcatttgccc atcacgctga taattgttta ctttgttgcg tgcgcggttg attggcagcg 884161 cttgatggtt tgcaccgaca cggtagcggt gtgcatcatg ataagcaaaa agtcgacctt 884221 gaagcatttt atccggtgaa acatcaatac caggcacgag ggttccaggt gaaaatgtcg 884281 cttgttctac ctctgcaaag tagttttccg gatttctgtc tagaaccatg cgtccgacct 884341 cgattaacgg gtagtctttt tgagaccaaa cttttgtgac atcaaacgga tcgaaacggt 884401 acgtatttgc atcttctaaa ggcatgattt gcacatatag tttccatgca ggataatcac 884461 cgttttcgat tgcgttgaaa aggtcttctg tatggtaatc agggttttca ccggcaattt 884521 ttgctgccgt attgacatca aggtttttca cgccttgttc tgttttaaag tgatatttaa 884581 tccatacgcc ttcgccttcg gcatttgtcc atttgaatgt atggcttccg aagccgtgca 884641 tgtggcgaag tgtcgcagga attccgcggt cagacatcag gattgtcact tggtgcagtg 884701 actctggtga aagtgaccag aaatcccata cagccgtagg gtttttcagg tgtgtttttg 884761 gatctctttt ttgtgtatgg atgaaatcag ggaacttaat cgcatcgcgg ataaagaata 884821 caggcgtatt gttgccgacg atgtcgtagt ttccttcttc agtataaaat ttaacagcaa 884881 atccgcgcgg gtcgcgaact gtgtcagcag agccaagttc accggcaact gttgagaaac 884941 ggatgaacaa cggtgtgcgt ttgccgactt cagaaaggaa agcggctttc gtgtattttg 885001 ttacgtcgtt tgtcacttca aaatatccgt gtgcgcctgc tcctttggcg tgaacaacac 885061 gttcaggaac acgttctcgg ttgaaatggg ccaatttttc gagtaaatgt acatcttgaa 885121 ttaaagttgg tccgcgagaa ccggcagtca ttgagttttg attatctcca accggagcgc 885181 cccagctagt tgtcagttta tttgaactca tgttatcacc tcttggaatt tataagaaca 885241 taatatcatc tctaagtaaa aagtcaatat tattttataa ttattataaa atagttatct 885301 ctattaatcg atatatagta tcgaaattgt tgaaaaacct tgttgtaaca gctttttatg 885361 acacttaata atttttggag aaataatttt tccttctcta tttgcgaaac aagcagagta 885421 agtgataaac aaggatatca aaaatcgtat ttaaaaaaga gttgacatat cggaataatt 885481 tgaattaaca tgttattcaa acaaaaaaac aattgggcag ctgatcggac cgccgaaggc 885541 tctcatctct acaagaacag agatgggggc ctttttgttt tttttgaagg cggggttggc 885601 agaaagagag ggataaaagt ggctgtgacc atcagcatca aagaaaaggc atttgttcaa 885661 gaaggccgca aaaacacggt cttagaaaac atagaattat caatcgcacc aggcgaattt 885721 ctaacgctta tcggaccgag cgggtgcgga aaaagcaccc tgttaaagat tattgcaggg 885781 cttgattctg aatatgacgg gagtgtggaa attaacggcc gcagcgtaac agctccgggt 885841 attcagcaag gatttatttt tcaggaacac cgcctctttc cttggctgac tgttgagcag 885901 aatattgcag ccgacttgaa tttgaaggac ccaaaagtca aacaaaaggt ggatgaactg 885961 atcgagattg tcagattgaa aggatcggaa aaagcatatc cgcgcgagct gtcaggcggc 886021 atgtcacaaa gagtagccat cgcccgggcc ctgctgcggg agcctgaggt gctgctttta 886081 gatgaaccgt ttggtgcact cgacgctttt acaagaaaac acctgcagga cgtgctgctg 886141 gatatatgga ggaagaaaaa aacaacgatg attctcgtga ctcatgatat agatgaatct 886201 gtttatttag gaaatgagct tgcgatcctt aaggccaaac cggggaaaat ccataagctg 886261 atgcccattc acctggcgta tccgcgaaac cggacgactc cggatttcca agcgatcaga 886321 cagagagtgc tgtcggaatt cgagaaaaca gaagatttgg agtacgcaga aggatcaggg 886381 atatagaaag ggcggaagcg gaaatgaaaa aaggactcat tgtattggtt gccgttattt 886441 ttctgctcgc aggctgtgga gcaaatggag ccagcggtga ccacaaacaa ttgaaggaaa 886501 ttcgtattgg tattcagcaa agcttaagcc cccttttgat tgcaaaagaa aaaggctggt 886561 tcgaagatgc atttgaaaaa gaaggcatca aagtgaaatg ggtggagttt caaagcggtc 886621 cgccccaatt tgaaggcctt gcggcagaca aacttgattt ttctcaagtc ggtaattcgc 886681 ctgtgatcgc tggacaggcg gcaggcattg actttaaaga aatcggtttg tctcaggacg 886741 gcttgaaagc aaacggcatc cttgtcaatc aaaacagcgg cattcaagac gttaagggct 886801 taaaggggaa gaaaattgca gtcgccaaag gcagcagcgg gtttgatttt ttgtataaag 886861 cgcttgatca agtggggttg tcagctaacg atgtgacaat tattcagctt cagcctgatg 886921 aagcagcttc cgcatttgaa aacggatctg ttgatgcctg gtccatttgg gagccgtact 886981 tgtccttaga aacaatgaaa cacggagcaa aaatccttgt gaacggagaa agcacagatt 887041 tatattcacc gggttttact ttagtaagaa caaagttttc agaagagcat ccagacgaag 887101 tggtccgttt tctgaaggtg tttaataaag ccgttgtatg gcaaaaggaa catctggatg 887161 aagcagcgga cttatattct gacattaaag atctcgataa aaaggtcgtc gaaaatgtgc 887221 tgaaaaatac tgagccactt aatgagatca tcagtgacga cattgtgaaa gcacagcagg 887281 aaacagcaga ttttcaattt cgaacaaagg cgatagataa gaagattgat gtgaaggatg 887341 ttgtcgataa cacttttatc aaaaaagcat tagaggagca ttcctcagga ggtgatcaat 887401 gatgaaagca gaggctgcgg gctcgctgcc caaaacgaat gcggaagcgg tgcgaaaaaa 887461 gcccggaagg aagagatacg gctggatgaa ggggctttta ctgcccgctg tcatcattgc 887521 catctggcag gtcatcggcg ggctgggggt tgtgtccgct acagtgctgc ctacacctgt 887581 tacgattgtt ctgaccttta aggagcttat tttgtccggc gaactgttcg gccatctgca 887641 aatcagcatt tatcgggcgg cacttggttt tttgcttggc gcggggcttg gattgatgat 887701 cgggattttg gccggatttt ccaaacggac ggagctgtat cttgatccgt cgttgcaaat 887761 gcttagaacc gtacctcatc tggccgtcac gccgctgttt attttatggt tcggatttga 887821 cgaagtatct aaaattttgc tgattgcgct cggtgccttc tttcctgtct atatcaatac 887881 gtttaacggc atccgcgggg ttgacgcgaa gctgtttgaa gtcgcccggg tgcttgaatt 887941 taaatggcat cagcagatat ccaaagtgat attgccggca gccctgccca atatattgct 888001 aggcattcgc ttatcgctcg gcattgcatg gctcgggctc gttgtggcag agctgatggg 888061 ctcaagctcg ggagtcggct atatgatcat ggatgcgaga cagttttcac aaacgaataa 888121 agtctttgca gggattatca tttttgcagt ggttggaaag ctgacggatt ccttcgtcag 888181 gctgcttgaa cgaaagctgt taaagtggag aaacagctac gaaggataaa agatataaag 888241 gggagatgaa tatggaaatt ctttggttta taccgactca tggagacgcg agatatttag 888301 gatctgaaag tgatggacgg actgcggatc atctttactt taaacaagtc gcgcaggcgg 888361 cagacaggct gggatataca ggagttcttc tgccaacggg aagatcgtgc gaggacccgt 888421 ggcttacagc gtcggcactg gcaggagaaa caaaggactt aaagttttta gtcgcggtaa 888481 gacctggttt aatgcagcct tctctggcag ccagaatgac atccacccta gaccgcattt 888541 cagacggccg gctgctgatc aacgttgtgg cagggggcga tccgtatgag ctggcaggcg 888601 atggcctgtt tatcagccat gatgagcgct acgaggcaac agacgaattt ttaaccgttt 888661 ggcggagact tttgcaggga gaaacggttt cctatgaagg aaagcatata aaagtggaaa 888721 acagcaatct gcttttcccg ccgcagcaag agccgcatcc gcccatctat ttcggtggtt 888781 cgtcacaggc tggaattgaa gctgccgcaa agcatacaga cgtgtacttg acatggggtg 888841 agccgcctga acaagtaaaa gaaaagatag aaagagtcaa aaagcaagcg gcaaaagaag 888901 ggagatccgt tcgatttggc attaggctgc atgtcattgc ccgtgaaact gaacaagagg 888961 catgggaagc ggcagagcgc ttgatcagcc acttggatga tgacaccatt gccaaagcgc 889021 aggcagcttt gagccgttac gactcttcag gccagcagcg gatggccgtc cttcatcaag 889081 gcgatcggac gaagcttgaa atcagcccga atctgtgggc ggggatcggc ctggtcagag 889141 gaggggcagg aacagctctt gtcggtgatc cgcagacgat tgccgaccgg atagcggagt 889201 accaggcact cggcatagaa tcgtttatat tctccggcta tccgcattta gaagaagcgt 889261 attattttgc agagcttgta tttccgcttt tgccgtttga aaatgatcgg acgagaaagc 889321 ttcagaacaa aaggggagaa gcggtaggaa acacttattt tgtcaaagag aaaaatgcat 889381 gagtttaact aaaatacagc cccccgaaca tggtatgata ttcaaaaaaa gggggctttt 889441 tttctgaaaa cattgagaag cgcggcagtc atttgcctca tagctatgct gtcagcatgc 889501 ggacattcaa aacagatgga aatcaaagcg gcggacatat cagatcttga aaaaaacaga 889561 atggatgtcg cagcttcaca ggcattcact gccgaagccg tcaatatcgg tgaaggtatt 889621 tcttcagctg acatgtacat cgaacattat caaaagggaa agcttgttga gaggtttgga 889681 ccggttcgtg cagattattc agaggaaaaa actgatacca tacaatttgt ttattttgag 889741 aatgaagagg gggaaggaaa gaataaacat accaccattc attttggcat tgtggataaa 889801 cagggaacta tagcggctga ttcatcggtg aaacgcgacg atagcacaac acaggaaatg 889861 actcagaata tttcatcgcc ggaaccgatt actttcgaga agcctgcttt gatcggcagc 889921 agtattagag ggactgacga gacaatgcac acctctgaac ataaaaaaga gctcattaag 889981 catcaagatg cgttactgta ttatgtggaa ttgcatcatt agaatgggcg gcttcaggcc 890041 gtctgtttta caaagcggta tgcttgcttt tttgaatggt gaatgataca ttttaaatcg 890101 taacaatttc gatttaaagg gaggctatgt gacttggcta aaaaatcaaa agtggcaaaa 890161 gagttaaaac gccaacagct tgttgagcaa tacgctggta ttagacgcga gttgaaggaa 890221 aaaggagatt acgaggcact cagcaagctg ccaagagatt cagcaccggg aaggcttcac 890281 aaccgctgca tggtaacggg gcgcccgaga gcatatatga ggaagtttaa aatgtccaga 890341 atcgctttca gggagctggc ccataaaggc cagattcccg gtgtgaaaaa agcaagctgg 890401 taagaaaaaa ctccggccga ttacagcgcg ccggagtttt tttcgttttt cttgaaagag 890461 atgacgtagg aaaggtgctg gatgatcatg atgataaaca caataataat agggaaaaac 890521 ggaatgcgcg attgaaatag cggataaaaa atgagaagaa ccgctgcggc aggcagcgag 890581 aagtagacag cgatatatga cgcgcgacat gcttttgccg tcatcatctg ctctctttca 890641 tcctgctctt caaactcatc aggcagaagt agctgctttc tggcagggcg gctttttttc 890701 tgtaagtaca aataaaccgc agacgccgca acaaacagaa taaagggagt gaggtttaaa 890761 tcaaatacca tcccgccgct ctttgtgccg aaaaaagatg ctatgccttc tgaggcttca 890821 aagtatgaaa tcagcgccca gcatgcaagg ccaaataaaa caaggtgaaa agctgctttt 890881 gttttcatgc tcatcttagt tttcctcctc taaccaaaag acatcctcca ttttcatgga 890941 gaaggctttg cagattttca gtgctaacag cagtgaggga acataatcgc ctttttcaat 891001 cgctgccaca gtctgtcttg tgacgccgac cgtttctccg agtttttcct gagaatagcc 891061 gaagcgtgcc ctcagctctt ttactttatt tttcatcatg acgtctgtcc ccttcacaat 891121 ctcgattgat tatattgtat agtatactta acattatgta aatggaactt aacaacttta 891181 caaaaagata actttttttc gacaaaattt ttatattccc ttgacgaaaa ataaataaac 891241 atgtaatata aaaaaagtca gagcggtact gttgctgaca atcacaaatg cgggtgtagt 891301 ttagtggtaa aacctcagcc ttccaagctg atgtcgtgag ttcgattctc atcacccgct 891361 ccatacatac gttattaacg cagtgtttcg tttctcagat aaacgaagta ttgcgttttt 891421 ttatgtgaaa aagaacacgg tattcgtgtt cttttacgta agccaatgta ctgtatgggt 891481 gccgccgtga atttgttcaa acattttcgt taatgatgat aagaggttaa cagcgctgct 891541 tttctcaatc gatggcggga aaaaaatgat ttgcagcata ttcttagtct cgtttgaaac 891601 gggatagtgg ttgacgctgt ttttgaaatc gccaaaaatg ccgttttcat cagagaaaag 891661 cagtatgttt tctttttctc ccaatgagat ccggaccggc tcatgaagct ttccggcatc 891721 ataaatcata ataggcagag aatattttaa tgcgaaaaaa tcgattgtgt catgggccga 891781 gtctttactt tccatgaatt gttccttgga tatcgggacc agcatgtcct ccattggggt 891841 tgtttctccc tcaaatgaag ggttaagctg tttaaagagt ttctgccatt ccttgacgaa 891901 ggattcatcg gatataccgc cgtccgcata gtcgaaaaac aaggattctt gaaacaggcg 891961 gagtctgcct ttcagcattt gcggtgagga gccgacttcg atattctcat aaatgacagc 892021 agctgcatgt aagccggccg cacgttcagt aataacagaa tcaagtttga tattcactag 892081 cattcactcc agttacgtga tatcaaccta ttataaacgc tgtgtcgttt tatcacaaag 892141 aaaggaggct gtgcaaaaca tgaacgttta tcagctcaaa gaagaattaa ttgaatacgc 892201 gaaaagcatt ggcgtagaca agattggttt tacgaccgct gatacttttg acagtttaaa 892261 agaccgtttg attcttcaag aatcactcgg ctatctctcc ggctttgaag agccagatat 892321 cgaaaaaagg gtgacgccga agcttctttt gccgaaagcg aaatcaatag tggcaattgc 892381 tctcgcatat ccttccagaa tgaaggatgc gccgagaagc acgagaactg agcgcagggg 892441 cattttttgc agagcttcct ggggaaaaga ctatcatgat gtgctgaggg aaaagcttga 892501 tctgctggag gattttctaa aaagcaagca tgaggatatc agaacgaagt caatggttga 892561 tacaggtgaa ttgtctgatc gcgccgttgc ggaacgtgcc ggaatcggat tcagtgcgaa 892621 aaactgtatg atcacaacac ccgagtatgg ctcttatgtg tatttggcgg aaatgatcac 892681 aaatatccct tttgagcctg atgtgccgat tgaagatatg tgcgggtcct gcacgaaatg 892741 cttggacgcc tgcccaacgg gagcactggt taatcccggg cagcttaatg cgcagcgctg 892801 catctctttt ctgacccaga caaaaggatt tttgcctgat gaattccgga caaaaatcgg 892861 aaaccgcctg tacgggtgcg atacgtgcca aacggtatgc cctctcaata aagggaagga 892921 ttttcatctt catccggaaa tggagcctga tcctgagatt gccaaaccgt tattgaagcc 892981 gcttttggcc atcagcaatc gggaatttaa ggagaaattc gggcatgtct caggttcttg 893041 gcgcggaaaa aaaccgattc agcgaaacgc cattctcgcg cttgcccatt ttaaggatgc 893101 ttccgcactg cctgaattga cggaactgat gcacaaggat ccgcgtcctg tcatcagggg 893161 gacagccgca tgggcaatcg gaaaaatcgg agaccccgcc tacgcggaag agcttgaaaa 893221 agcgctggaa aaagagaagg atgaagaggc aaagctggaa attgaaaaag gaattgagtt 893281 gctaaaagct tcaggcatga ctaaacaagg cctgtcctga catacgtata gagcagaagg 893341 aaaaaacact tgagatcatc caagtgtttt ttctctataa aaaagtatgg cgggtggggt 893401 gagcttgaag tacattttag aacaattagc ggaggagcgg ctgggctttc tggttaacgg 893461 gcatgctatg agacaggagt ctcaagtcgg agaccttaaa gtcatggagc gtaagaaaaa 893521 gcttctggaa aaacgtaaag ttgacatcat aaaagcgaaa gcaaaggccg tgattaatca 893581 tgtgcgggtt gaggatgacg gaacgacctg cctttcgtat accatccatt acgaatacgt 893641 gtgtaaggaa caagatgaca gcttgtatat agaagagcac atagaggagc gaatggcttt 893701 cctgtatgat cacattttga ttagtgatca ggaaattgcg aaaaagccgg ctggatttca 893761 tgaagggacc agtattattg actattctga agctgaagag gaaagagaag cgtttggcag 893821 ggcttttcaa tacgatcgtc tcggcgctgt ccaatatgcc gagaaatttt ggaacaagcg 893881 caatcctgct tataaaaatt tcagcgataa ctgtacaaat tttatttctc agtgtcttca 893941 tgcaggaggc gcgccgatgc gcggtcatcc gaacagggga tcaggctggt ggatgaaaca 894001 aagctcatgg agctacagct ggacggtggc tcactctatg aaaatgtatt tgtcgaattc 894061 aaaggccgga ctgcgtgcgg tgcgggtgaa atcagcggaa gaactgatgc cgggcgatgt 894121 gatttgctat gacttcgaag gagacggccg gtttaatcat acaacgattg tcgtggcaaa 894181 ggacaaaggc aatatgccgc ttgtcaacgc ccagacttat gacagcagga tgaggtattg 894241 gtcatatgag gattctacgg catacacgcc gtcaatacga tatgcctttt ttcatatcgt 894301 tgatgatacg acaaaagagt aattaatgtt ataatgatgg gcggataaga aaaacagagg 894361 tgaacattgt ggcattacat gtcgttttat atcaaccaga aattcccgct aacacaggga 894421 atattgcacg tacttgtgca gcaaccaata caacgctaca cctgattcgt ccgctcggct 894481 tttcaacgga tgataaaatg ctgaagcgtg ccggactcga ttattgggag tttgttaacg 894541 ttgtgtatca tgattcgtta gaagaattgt ttgaggcata taaaaaaggc aagtttttct 894601 ttattacaaa atttggccag cagcctcata catcatttga ttacactgat cttgacgagg 894661 attatttctt cgtgttcgga agagaaacaa gcggtttgcc aaaggattta attcaaaata 894721 atatggaccg ctgcctgcgt cttccgatga cagagcatgt cagatcgtta aatctgtcca 894781 atactgccgc gattcttgtt tatgaagcgc tgcgccagca aaattaccgt gatttaaaat 894841 agtgaaaaac ccgctcatcg atgatgggcg ggtttttttg cggatgttga aatgctttgt 894901 ttcgtttttg ggcttaacaa cgtaacagtg ttatgttaca atgtacccat caaaggagct 894961 ggacttatgg aagaacaatt aatctctaaa aaagaattac ttgaaagaac atcgatttca 895021 tacggtcagc tgtatcgatg gaagcggaaa aacttaatac ctgaggaatg gtttattcgt 895081 aaatccacat ttacagggca agagacgttt tttccgagag aggagatttt aaaacgtata 895141 tcaatgattc aaaagatgaa agaaaatttg tctttggatg aaatgaggga aatgctgtcg 895201 ccgaaaatga aggatgtcag catgaccgct gatgaattgc ttcataaagg tttggtttca 895261 aggcctgctc ttgaagccta ttcagaagac ggaggaagtc cggttttttc atccagcgat 895321 ttgctttcgc tgtttgtgct tgagggcctg ctgcagtctg gaaatgtcag ccttgcagaa 895381 gcaaaaatgg ctgcagaggt attaaagaag catgatactg aagagattga aaaacagacg 895441 gagctgattg tgctccgcaa gctcggtgtc acaacttgtt ttatagcggc tgcggcggac 895501 agcattttgt ttgaatcatc cgtaaaggtt gtggaacggg tagatttatt aaaagcttca 895561 gaggaattaa aaacaacatt tatgcaggag ggccatcaat ggatgtagtg gaaaagctgg 895621 tgataaatgg atcaggaagt tctaagggag gaacatttca atcagttgag attaatggca 895681 gcgggacagt ggccggggac gtggagtgtg acactttttc ttttaatgga aacggaaaag 895741 cggacggcag cgtcaaagcg aaagcggtaa ctatcagcgg ttcaggaaag atacatggag 895801 acgttgaagc agaatctatc cggatgaatg gcactggttt tattcaagga gaggtatctg 895861 caaaacaatt gaaaatcgct ggatcatcaa catttggcgg cactgtcaag gctgatggaa 895921 ttgacattag cggaaaagct gtcatggaag cagattgtga aacagaaacc tttcaatcag 895981 aagggaaatg caaaatcagc gggcttttaa atgcagacca ggtgatcatt aagctttctg 896041 caggggaaag ctatgcgcgg gagatcggct gccgccatct tcaagtgacc tgcagaaaag 896101 gaatgctgac attgctcaga ttgatgccgc agcctgttct aacagcagag ctgatcgaag 896161 gtgacgtgat tgaattgaca aatacaaagg cgaaaaccgt gcgcggtaat aaagtgatca 896221 tcggcccgga ttgccagatt gaaaccgtcg aatacagcgg ggactatacc tgtgatccaa 896281 gcgcgtcggt tgaaacatcc acaaagttgt aaggaggatc gtaatggaga caacaaaact 896341 gggaaattta aaattatatg gcgctgggca tgccgcagga ggcgcgtatc acaatgtcag 896401 catcaaagga gaaggtatag ttggagaagg gctgtctgct gtaggctgcc gcatatacgg 896461 aacgggcctt tttctcggaa aagcagagac tgagcggctg cgtgtgctcg gagaaagtga 896521 atgtaaaggc gatctgacag ccggcaaaat caatatatat gggacaatga aagtcagcgg 896581 ctcacttcaa tttgatcgat tcaatctgaa aggccagact gaaattggcg ggaatatgac 896641 tggagaatcc tgcgatgtga aagggaagct tagcgtaata ggtgattgtg aaacagaaat 896701 gttccatgtc acaggctgtg ttgatgtatc ggggttatta aattcgggtg agatcaagct 896761 gggattgagc catgatataa gccatgtgca ggaaatcggc ggaacaacaa ttacagtgaa 896821 aagacgcgcg agttttttta gccggaagaa agggaagctg atcgccgatg tcatagaagg 896881 agatcgggtt tatttggaga ataccgaagc ggcagttgtc aggggaaaag aagtgatcat 896941 cgggccggga tgcagcatcg gaacgattga gtacgaatac aaatgtgaat gcgatccgca 897001 ttcacagatt aaagaaaaaa caaaactgta aaacattgtt ctgttataca aaaagggtgc 897061 tctttcagga gcaccctttt ttattctttt ccaggcttgc tttcgtatcc tgcggtaaaa 897121 attgatacta aaaaagtgac aatgacaccc atcatgatga ttgttttcac cgtctctccc 897181 cctcttcaat ttttccgtgc tgtccgagtc tggatgattc tgtatttttc tttattatga 897241 acggtcgcag tctgccttgt caacgatgta tgagtatctt tatttttaag aaaccaaagc 897301 atgtatcacg agatggcggc atagattgta tcaaagtacc ttatttgcat agtgtatcaa 897361 acatgataga ggaggtcctt atggatatat taaagaaaat tgaaaagtac agagaggaag 897421 agcagcggct gaaatgggaa ggaactttcg ccgattattt ggagattatt aaagaaaatc 897481 cgatggtcgc gcaatctgct cattctcgag tttttaatat gataaaagac agcgggatag 897541 aggagattga cggacgcaag aagtacagtt tttttgaccg cgagctgttc gggcttgaag 897601 aatctctgga gcgtcttgtg gaagagtatt ttcatccggc tgccaaacgt ctagatgtca 897661 gaaagcggat tctattgctg atggggcctg tgagcggcgg taaatccacg ctggtcacaa 897721 tgcttaaaaa aggtctcgaa gcgtacacgc tgacagataa tggcgctgta tatgcgatta 897781 aaggctgccc gatgcacgag gaccctctac atttaatccc ccatcattta cgcgatgact 897841 tttacagaga atacggcatt agaatagaag gaagtctttc tcctttaaat gtcatgaggc 897901 tggaggaaga gtacggagga agaattgagg atgtgaaggt ggagcgcatc ttcttttcag 897961 aagataagcg tacgggaatt ggaacattca gtccctctga tccgaaatct caggatattg 898021 ccgatttgac ggggagtatt gatttctcaa caatcgccga gtacggttca gaatcagatc 898081 cgcgcgctta tcgatttgac ggagagctga ataaagcgaa ccgcgggatg atggagtttc 898141 aggagatgct gaaatgtgat gagaaatttc tctggcattt gctttccttg acacaggaag 898201 ggaattttaa agctgggcgg tttgcgttaa tttctgctga tgagctgatc gtggctcaca 898261 cgaatgaaac ggagtatcgc tcatttattt ctaataagaa gaatgaagcc ctgcactcaa 898321 gaatcatcgt gatgccggtt ccttataatt taaaagtgtc tgaggaagag agaatttatg 898381 aaaaaatgat tgcagaaagc gatgtggcgg atgttcatat tgccccgcat acgttgaagg 898441 tcgccgcgat gttctcaatc cttacccggt taaaagagcc gaagcggtcg gatattgatc 898501 tggtcaagaa aatgagactg tatgatgggg aaagtgtgga aggatataac tctgtcgacg 898561 ttgaggatat gaaaaaagaa tataatgatg aaggcatgag cggaattgat ccgcggtacg 898621 tgatcaaccg gatttcttca acgattatca gaaaaaatat ggaatcgatt aattctctcg 898681 atgtccttcg ctccttaaaa gaaggtcttg atcagcaccc atcaatttca agcgaggaca 898741 gggagcggta tttgaatttt atctctgccg cccgcaagga atatgacgat attgcgaaaa 898801 aggaagttca aaaagcgttt gtttattcat atgaagaatc agcaaaaaca cttatggaca 898861 attacctcga taacgtagag gcctattgca ataaaaacaa gcttcgtgat cctttgacag 898921 gagaggaaat gaaccctgac gaaaagctga tgagatccat cgaagagcag atcggcattt 898981 cggaaaacgc caaaaaagcg ttccgcgaag aaattttaat ccgcatctcg gcctatgcga 899041 gaaaaggcaa gcggtttgat tacaattccc atgaaagact gcgtgaagct attcagaaaa 899101 agctgtttgc tgatctgaag gatgtcgtta aaattacgac ctcaacaaaa acgccggatg 899161 agcagcagct gaaaaaggta aatgaagtcg tggcccgttt aattgatgag cacggctaca 899221 actcgacgag cgccaatgag ctgctgaaat atgtcggcag cctgctgaac cgataagcaa 899281 cgtgacccgt ccgaataggg cgggttattt tgtcccattt tctaaatagt ttgtcaatta 899341 aacgtgcata tgtgcatatg atgaatataa atcttttcaa aagacttgtt tcataatctg 899401 gcacaagccg gaatacgtat gtatcacgac cacaaatggt taaggagggg aattcatgtc 899461 ccaaaatgac agcggccatt ttttgatttc tgaggaaaac tggtccctcc atcgcaaagg 899521 cttcgatgac cagcagcgcc accagaaaaa agtgcaggaa gcgatcaaaa acaatcttcc 899581 ggacctcgta actgaggaaa gcattattat gtctaatgga aaagatgtag tgaagatccc 899641 aatccgttca cttgatgagt ataaaatccg ttataactat gataaaaata aacatgtagg 899701 gcaaggagac ggcgagagcc aggttggaga tgttgtggcc cgggatggat cagacaaaaa 899761 acaagggcct ggaaaagggc agggtgccgg tgatcaggca ggcgaggatt attatgaagc 899821 ggaagtttca ttaatggatt tagaagaagc gctttttaaa gaattagagc ttccgaatct 899881 ccagcaaaaa gagcgggaca atatcattca tacagatatc gagtttaatg atatccgtaa 899941 aacagggtta accggtaata ttgataagaa aagaacgatg atgtcagcct ttaaacgaaa 900001 cgcaatgtca ggaaaaccgt cgttctaccc aatttatccg gaggacctga aatataagac 900061 gtggaatgac atcacaaagc ccgaatcaaa agccgtcgtt ttagccatga tggatacaag 900121 cggcagtatg ggggtttggg aaaaatacat ggccagaagc ttctttttct ggatgacccg 900181 ttttttgcgg acaaaatacg agactgtgga aattgaattt attgcccatc atacagaagc 900241 aagagtggtc tcggaggagg attttttctc aaagggagaa agcggcggaa caatttgttc 900301 ttccgtatat cggaagtcgc ttgagcttat tgatgaaaag tacaatcccg cccgctataa 900361 catttacccg tttcattttt ctgacggtga caacctgaca tctgataacg cgcgctgtgt 900421 gaagctggtc aatgatatta tgaagaaggc caatctgttt tgctacggcg aggtcaatca 900481 gtacaacagg cattcaacgt taatgtctgc atataaaaat gtaaaagatg agaaatttaa 900541 gtactatatt ttaaaacaga aatctgatgt ttttcaggct ctaaagaact ttttcagaaa 900601 tgaagagtct ggtgtaagcc atcaattttc gtaatgaaaa gcccatttca gggctttttt 900661 ttatttaata aaagcaagaa aacgcttgcg aaaaaaatac gggagaaaaa gaaatttttc 900721 ctttgacaaa tcttctttca tttattaata ttttatcttg tgaactatta ttgaggaatg 900781 aggtgaaaag gagttgactg aatcagaacg tgctttgctc acttttgaac agctcttcga 900841 tacgtctcgg gcgatatata aaaaacagaa gaagatattg gagattgtgc ttgagccttt 900901 tgatattaca gtccttcaat atttgctgat gtttaaaatt catcaaagcg gaagcacccc 900961 gctaagcaag ctggcaatgt cgcttgatct taagcctgct tctgtgacgc ggatgacaga 901021 tattctgtat aagcgccaat tgatgaatcg atatgacagt ccggatgacc gccgtatcgt 901081 catgattcag ttaaccgaag agggggaaga actgatagaa aaagccgctg tgcaatatgc 901141 aaaaatgggt gctggcttgt accaaaagct tgatacctcc cagctgcagt atttgcgcaa 901201 actagccgga agtttaacga agcttgctga aggctgttca gaaaaaagcg gtaattaaaa 901261 acttctcaca tattttcacc agctttccgc aaaatgatag aggatgaaac gaaaggagaa 901321 aacaaaatga acagaggacg tttaattctg accaacatta tcggtttgat tgttgttctt 901381 gcaattatag ctggaggtgc ttactactat tatcaaagca caaactacgt aaaaacagat 901441 gaagcaaaag tagcgggcga tatggctgct attactgctc cagcagcagg taaagtatct 901501 gactgggatc tggacgaagg aaaaacagtg aaaaaaggcg acacagttgc aaaaatcaaa 901561 ggtgaacaaa ctgttgacgt aaaatccatt atggatggca caattgtgaa aaacgaagtg 901621 aaaaacggac aaaccgtaca agctggtaca acaattgcac aaacgattga catggacaac 901681 ctatacatca cagcaaatat taaagaaaca gatattgcgg atattgaagt aggaaatagt 901741 gtagacgtag tagttgacgg agaccctgat actacatttg acggtactgt agaagaaatt 901801 ggttatgcga ctaactcaac ttttgatatg cttccttcta caaattcaag cggaaactac 901861 acaaaagtaa cacaaaaagt tcctgtgaaa atttcaatca aaaacccatc tgataaggtg 901921 cttcctggaa tgaatgcatc tgttaaaatt tctgagtaaa acagatcagt catcaaacca 901981 tgaaaggagg ttgtcttaga tggctacagg caaagaaaaa aatgcaaaaa accctatgtc 902041 attgctgatt gtgctaatgg cgggtttatt tttggcaatt ctaaaccaaa cactgcttaa 902101 tgttgcaatg ccgcacttaa tgactgaatt tggcgtaagt gcaacgacga ttcagtggct 902161 gacaacaggt tacatgcttg ttaacggtgt attgattccg ttatctgctt tcctgattac 902221 acgatttggc cagcggagtc tctttctcgt cgcgatgttt tgttttacgc tcggtacgtt 902281 agtctgcggt atcgcaccta acttctctac aatgctgatc ggccgtttga ttcaggccgt 902341 gggcggaggt atcttgcagc cgctcgttat gacaaccatt ctgttaattt tcccgcctga 902401 aagcaggggg aaaggaatgg ggattttcgg gctagcgatg atgtttgctc cagcggtcgg 902461 cccgactctt tccgggtgga ttattgagca ttatacatgg cgcattatgt tttacggact 902521 tgtgccgatc ggcgcaattg ttatcattgt ggctttcttc atctttaaaa atatggtgga 902581 gccgcaaaaa atcaaactcg atactcttgg cgcaatcctc tcgattgtcg gattcgcctc 902641 cttattatac ggagtcagtg aagccggatc tgacggctgg accgacccga ttgtattgtc 902701 tacagttatt atcggagcca ttgcaattgt tgcttttgtt gttcagcaat tgcgtcatga 902761 tgatccgatg cttgatttca gagtgtttaa atatgacatt ttctcactct cgagtgtcat 902821 taatatcatt attacagtgg cactttacac tggtatgttc cttttaccga tttatctgca 902881 aaacctggtc ggctttacgg cgcttcaatc cggtctgctt ctgcttccgg gtgcgatcgt 902941 tatgctgatt atgtcaccga tctcaggtat tttgttcgat aaattcggac cgagaccgct 903001 tgcgattatc gggcttctcg tgacagtggt aacaacgtat caatacacgc aattgacaat 903061 tgatacacca tatacacaca tcatgctgat ctattcaatt cgtgcatttg gtatgtctct 903121 cttaatgatg ccagtcatga cagccgggat gaaccagctt cctgcccgtc tgaacagcca 903181 cggaacggcg atgagtaaca cgcttcgcca aatcagcgga tcaatcggaa caagtttaat 903241 tacgacgatt tatacaaacc ggacgacatt ccattattca caaattgcag ataaaacaag 903301 cacggcggac ccgaacttcc tccatgcgtt ccaaaatgca gtttcgaatt taatggtgaa 903361 tatgaatgtg tcttatgata cggcgaaaac atatgtgtac tcacatattt ataaacacgc 903421 atcactcgat tccaatgtca tggggataaa tgatgccttt atgtgggcaa ccttattctg 903481 tgtagcaggt ttgattttaa gtatcttcct gcgtgacgtc agaaaagata aattgcgtaa 903541 gaagaaaaaa gaggagcttt cattacttcc tgctccaaaa gaagctaagg aatcttaatc 903601 tgtacaggga ggtttcctga atgaaaattt atgtagtgta tgatagtgaa ggcgaacata 903661 ctaaagtgct tgcagaagcg attgctgaag gcgcgagaga aaacgacgcg gctgaagtgt 903721 tcatcgacca tgtagatcag gctgatatcc gcaagcttaa agatatggat gcgattattt 903781 ggggatgccc agggcatttc ggaacaatca gctccggtct taaaacttgg atcgacagac 903841 ttggctactt gtgggctgaa ggcgagctga tcaacaaagt cggtgctgtc ttctgcacaa 903901 cggcaacaac acacggcggc ttggaaatga caatgcacaa tttaatcacg ccgatgttcc 903961 accaaggcat gattgttgtc ggactgcctg gcaacgtgcc tgaaaacgca ctttatggct 904021 cttattacgg agcaggtgtc acttgtccgg tagacagtga tgagttaatg tctgaggaag 904081 gtattcagct tggacgcgcg ttgggaagac gtgtcagcca agtcacagga aacctaacag 904141 caggacagta aggagaggtt gaaatggcca ttattatagc aataattgct gctgtcattg 904201 tcattgcggc ccttattaca tttaacgtcc gcaacgcctc acctggacct gagaagcaag 904261 aagcaaccga tagaatcgca cctccagaag aggaaaaaaa cgaagcgcat taccctgctg 904321 aagcaagggc tgccgagcat acgccatccg ttgtcaaaaa cgattctcca aaagagaagc 904381 gtgacacaat gggtgatgat atttacaggc aggcgctgca aaagtttaag cattctgatg 904441 aagttcatgc agaagaagag gtcactgagg aaagtgacaa aatgcaggac cgcagctatc 904501 gtgatgcgct gctctctatg aaaaataaga aaaagtaatg aaaaaggcaa atccgtttac 904561 tcatgcgggt ttgccttttt tgctgtttcc atcaattatg tttttatcaa ataaatccat 904621 ggaatatgtt gtattccacc ttgatctagt gtactatgtt actcatacac cgaggatttt 904681 ttccgggagg taaagacatg aattcttttt taggtttatt aaagaaagat atcaagcttt 904741 caagaatgtg gctgctagta tggatatgcg gaatcatttt cttattggga acaggccata 904801 ttatagcttc tcgcacgaaa gaacctctag tcatttttgg tttttttgtt gcagttgctt 904861 tttttctgct tttcttatct cctgtttttg ttttttatca ccttcgcaag gaagggaaat 904921 cacagctttg gctgtacaat ccaaatggcg gcttatggct gttttcttct aaattggcag 904981 catctttgct ctatcaattt gtgattcagt tggcattaac agcctatggc atatggatgt 905041 atcatatgct ctctgtaaaa aatctgctgg agcatcaagt tgatataacg agtacagtgg 905101 ctttgctgaa tatgtatggg cttatttctt cgttagatat gtcagtaaca gtcattgtgt 905161 tttggactgt ttttcactct ctcagaaatt ggcgcggaat gcggtgggct gcgatggttc 905221 tgttggtcgc aatgtggtta ttcttcgatg aatacatcat aagccctttg gttgaatctc 905281 aaaagcattt ctggcctgta acagtctatt gcaattttga tttccacttc cacaatgttt 905341 ggagattgga actaaaacct atccatctgt ctgtgctagg gtttcctatt gctatagtca 905401 tcacattctt gctgctcatc atggcttcaa aactgcttga tcgtaaagta gaggtgtaaa 905461 tatggacaat caattccaat cctcgaaacc gatttatctg cagatcgctg atcagatctt 905521 ttataggctg gtcaggaagg agctgctccc aggagacaag cttccttcag taagagaaat 905581 ggcgattcaa actaaagtaa atcccaatac aattcaaaga acttacagtg agatggaaag 905641 gctgggtatt gtggagacaa gaagaggtca agggacgttt attgcggaaa aagcagaaat 905701 cgtagacgag ctgaaagaca agctgacacg agaggtgctg gaaggctttg tcaagcaaat 905761 gaaagagctg gggctaacga aagaagaaat gttagaaggg attaaaacat tcacagaggg 905821 aggctaaaat ggaaatcaag ctagaacatg tatcaaaaaa atacggccgc catacggccg 905881 tcaatgatgt gtcaatcacc ctatcatccg gacggattta tggcctgatt ggaccgaacg 905941 gcagcggcaa gtcaacgacc ctgaaaatga tggctggcct tctgtttccg acttcaggat 906001 ttgtaaaagt tgatgaagag caggttacga gagaaatggt gcgtcaaacg gcttatctta 906061 ctgagcttga tatgttttat ccgcatttca ctgttaaaga tatggtgaat ttttatcagt 906121 cgcagtttcc tgattttcat acagaacagg tttataagct attgaatgag atgcagctga 906181 atccggaaaa aaagatcaaa aagctatcaa aaggaaatcg gggcaggctg aaaatcgttc 906241 ttgctttagc gagacgggca gacgtcatct tgcttgatga acctttttcc gggcttgatc 906301 cgatggtcag ggattccatc gtaaacagcc ttgtgtcgta cattgatttt gagcagcaga 906361 ttgtcgtgat cgcgacacat gaaattgatg aaattgagac tttgttagat gaagtaatca 906421 tcctcgccaa tggagaaaaa gttgcgcagc gtgaagtaga agatattcgt gaacaggaag 906481 gcatgtctgt tttgcaatgg tttaaatcaa aaatggaagt ttgctagaaa gaggaggaat 906541 atgatgaaaa cagtgttgga attgaaaaac gtgactaaaa acatcagagg ccgaacgatc 906601 attgatgatc tcagttttac gattcgtgaa ggcgaggtat tcggtttttt aggaccaaac 906661 ggagcgggga aaacgacaac catccggatg atggtggggt taatgaagct gtcgaaaggt 906721 gatgtcctca tttgcggcca atcaattacg aaagaatatg ccaaggcgat taagcatatc 906781 ggagcgatcg ttgagaatcc cgagctgtat aaatttttga gcggatataa aaatctccag 906841 caattcgcaa ggatggtcaa gggtgtcacg aaggaaaaaa ttgatgaagt tgttgaactg 906901 gtcggtttaa cagacagaat ccacgacaag gtgaaaacat attctctggg gatgagacag 906961 cgtcttggct tggcacaatg ccttctgcac gatccgaaag tgctgatttt ggatgaaccg 907021 acaaacggcc ttgatccggc ggggatcaga gaaatcagag atcatttaaa gaagctgacc 907081 cgagaaagag gaatggctgt catcgtttca agccacctgc tgtcagaaat ggaactgatg 907141 tgtgatcgaa ttgcgattct gcaaaaagga aagctgatcg atattcaaaa tgtaaaagat 907201 gaaaacattg atgagaatga tacatatttc ttccaggttg agcagccgag tgaagccgct 907261 actgttttaa atcagtacga tttgctgagt aagacaaatg gtgtagaaat caaactggct 907321 aaagaggaag tccctgcggt tattgaattg ctggtgatgc agcaaatccg tatttatgag 907381 gtcaaggtca taacaaaatc attagaggac cgtttcttag aaatgacagg tgaaacaaaa 907441 gaggaggttc agcatgctta atttgattta taatgagtgg ctcaaaattt tcagccgtgc 907501 cggaacatgg gtgatgatcg gaattctggg gctgacaatg gttggatttg catttttggc 907561 gaatcatttt tctgccggtg aatcaaattc ccattggaaa caagagcttc aagcacaaaa 907621 cgccgaatta aagaaagaaa tcaaagaaga tccttcactg aaagatgggt ataaagaaac 907681 aatcacactc aatgactatc gcatcgagca taatatccct agtgacacgg gctatacggt 907741 atggtcttat gtaacggatt cagcaaactt taccatcctt accggtctgt ttactattat 907801 catcgcggcc ggaattgtcg cgaacgaatt taattgggga acgattaagc tattaatgat 907861 tcggccgctc agtcgttttc aaattttgat gtccaaatat attacagttc tcctgtttgg 907921 gctcctgttg ctgttgattt tatttatcgg ttctacttta ttagggttga tcttcttcgg 907981 aacgggtggt gaaaccgccg cgaatattca tttaatctat aaggatggcc atgtcattga 908041 gcaaaacatg atggggcatt tggctacaac gtatctttct gaatccgtct cggctttaat 908101 ggtggcgacg atggcgttta tgctgtctgc ggtattcaga aacagctctc ttgcggttgg 908161 tttttccatc ttcttgttgg ttgccggtac gactgcaact gcatttattg cagcgaaatt 908221 tgactgggca aagtatatat tgtttgctaa tgtcgacttg actcagtatg tggatggcac 908281 accgttaata aaagggatga ctatgacgtt ttctctcgtc atgctggcga tctactttat 908341 catcttcctg ttgcttgctt tcggaatctt catgaagcgg gatattgcaa actaataaaa 908401 aaagctgttt tgcttatgca aaacagcttt tttgtcaaaa taaaaactgc aggtttgcac 908461 ctgcagtttt tcatatcaat ttatgcttac gcttctttag taacgttagc agcttgtggt 908521 ccgcggtttc cttcaacgat ttcaaaagaa acagcttggc cttcttctaa agttttgaag 908581 ccttcgcctt gaatagcaga gaaatgaacg aatacatcgt cttgaccttc tacttcgatg 908641 aatccgaaac ctttttcaga gttgaaccat tttactttac cttctaacat gaaatttcct 908701 cctaaagcga tcataacgct taaattcact attcttgctc ttaacaaact ttcaagacga 908761 aaactcttac aaaactttct tcttaaagat agttcgaaca aaaataatta cctttactct 908821 accagtaatc ttcagaaaaa acaactgctt attgaaattt ttttcggaaa ataccatatt 908881 tatttttcaa tttgatattt atttacggaa attcatctgt tttctcgata tgtgatcata 908941 cgtttgcctt agtattcctt cattttggga agataagtaa taggaattga caaccttatt 909001 ggatatgagt aaggtaaaag ttaatcaata ttacaaatga caacgtttat caactaagag 909061 agcgtatgat ttttatgtct gatattgctt gcatgctcta atacatagat aggagtatgg 909121 tcacaatgaa aaagtggctt atatgcagtt tcgtccttgt tcttctcgtt tcatttactg 909181 catgttcacc gtctgcagaa catgaatcga taaaaatcgg gattgctgag tctgacgggg 909241 caatatggaa ctatattgct caaaaggctg aagaggcagg gctggatatt cagctgatcc 909301 ctttttctga ttatgcggag tctgatatcg cacttgctaa caaagaaatt gatgccaacg 909361 cctttcaaac catttcatat tttcagtcgt tcactgaaaa atacaaactt aatttggcac 909421 cgctcgggac gacatacata acgcccatgg gcatttattc aaaacgatat gaacgaatcc 909481 gagatatatc gcggggagct gtcgtttctg ttccggataa agcgttcgat tttggcaggg 909541 cgcttacggt gctccaggaa gcgggtttgc taacgctgaa aaacggattt aacggaacag 909601 gttcagttga tatgattaaa gataatccga gacacctgaa attaaaagct gtccggcaac 909661 aggatgcagt gagcggtgcc gacgtgtttg tcatgaaacc atcagaagca aaaaaagcgg 909721 gcttgaaccc gaaaaagcat acgctaaaga gcggcggact catgtctgag gaagagatga 909781 atttgattgt tgtcagagcg gaggatcaag atcgggaagc gctgcaaacc attcttgagc 909841 tttatcaagc tgatgataca gcggcattta tagaaaaaga atatcaggga gatcttgtcc 909901 cggcttttct gcctttgaaa cgtctttcag attggaagaa tgaattcgaa cattgaattc 909961 attctttttt ttctgaaaaa cacactctgt tccgtcccgt ttctttcgct ttgtaaagca 910021 tttgatcggc aagaatgggc aaggatcctg gctgttccgt attattgggg taatgagcgg 910081 cccctagtga tatcgtaact gaaagctcgt cgccgtttgt taatacaatc ggtgcatcac 910141 ttacagtgct cctgatccgt tcagcgatcc gggctgcttt atcaagagaa cagttcggca 910201 ggagcacggc aaattcttca ccgccgatcc gagcggcagg atcagtattt cggatggtct 910261 gcttcagacg taaccctagc tctttgagca cctgatctcc ttcatgatgg ccatattggt 910321 cattgatggt cttaaaatga tcgatatcca tataaatcag tgcaaattga aaatgcgggg 910381 tatcggccgc ctgctgatac agagcttttg tggtttcttc aaattttctt cggttataca 910441 cgcctgttaa aaagtcaaag tgcgcctgaa acttatattg tttaaaaaga agatgtgcat 910501 ttgtttcatg atcaataata tataaactga gcatgccgcc cgctattgat atgatccaaa 910561 aatacaaatg aagttcgtat gaatgtaaat ctataagaaa ataaaaggaa aaggagatca 910621 agctatttgt gattattaaa agatagaaag catgttttag ttgaactttt tttcttctag 910681 aaacaatgag tgacggaatg gcagcgatac aaatgataat aaccgagtat agtgcagatg 910741 tgttcatcgt aatcagcaag cggcctgcag tgatcatggc cagggccgtt gccgttgaaa 910801 cccagcctcc ataaagagcg gcaatcataa tagggatatt tcgaagatca ataattgaat 910861 gctgataggt aaatccaaaa accatcagaa taaccccgag caaaccgcag gccagtcctt 910921 taacagcttg aaaggatatg ctgtcttttt tatgtactag cctttcttta aacaggtggg 910981 tgaagagata attaaatgtg attaaaatgg tcaaatttac aaacagttct ttcagcaaat 911041 attatcaccc ttatataagg tactaaagat ggaagggaaa gaaaagaaca aaaaaggcat 911101 tatataaggt ttttttactt gaattgataa gttaaaataa ttcgcacttg acccatcgga 911161 attagtgtaa tatagtaaat gagaaaattt gaagggagag tttacctgct ttggagactt 911221 tactggttgt attacatgta tttattttat ttttacttat cttagggctc tttgttatgc 911281 agaaaaaaca tgtttccttc tctaaacgtg tatttactgc gctggggctg gggattgtat 911341 tcggatttgc gcttcagctg atttacggcc cgacttcaaa tatagtcatt caaacagccg 911401 actggtttaa tattgccggg ggcggatatg tcaaattgct tcagatggtt gtcatgccgc 911461 tcgtctttat ttcgattctc ggcgccttta caaagctgaa gctgacaaaa aatcttggga 911521 aaatcagcgg tttgattatc gggattttag tagcaacaac agcagttgct gcagctgtcg 911581 gtatcgcgtc cgcgctttca tttgatctgc aggcgattca ggttgaccaa ggaagtacag 911641 agctttcacg gggacaggag cttcagcaga aatcagagga tatgacagcg aaaacgctgc 911701 cgcagcagat tgttgaactg ctgcctggaa acccgttttt agattttacg ggagctagac 911761 cgacttcaac gatcgctgtc gttatttttg ccgctttcct tggagtggca ttcctcggcg 911821 taaaacacaa acagccggaa caggcagaaa catttaaaaa actggttgat gccgtttatg 911881 ccattgtcat gcgtgttgtc acactcattt tgagactgac gccttatggg gtgctggcca 911941 tcatgacaaa aacaattgca acgagtgatc ttgacagcat tctaaaactg ggcatgttcg 912001 tgattgcatc atatgccgcg ttaatcacta tgtttatcat tcatttgctg ctgctgacgt 912061 tcagcggctt gaatccggtg atttatttga aaaaagcggt gcctgtactt gtatttgcat 912121 ttacgtcaag gtctagcgca ggtgctttac cgctgaatat taaaacacag agaagcatgg 912181 gtgtaccgga gggaatcgca aactttgccg gttcgttcgg tctttcgatc ggccaaaatg 912241 gatgtgccgg catttatcct gcgatgctgg cgatgatgat tgctccgact gtcggccaaa 912301 atccatttga cccggtgttt attatcactg ttatcgcagt cgttgccatc agctccttcg 912361 gggttgccgg agtcggcggc ggagcgacat tcgcggcgct tcttgtttta tcatcattaa 912421 acatgcctgt cgcgctcgcc ggtttgttaa tctcaattga accgttaatc gacatggggc 912481 gtactgcttt gaatgtcagc ggaagcatga catccggtct tattacaagt aaggtcacaa 912541 aagaaattga tcaaggggca tttcatgatc aatccagagt gattgaagct gaagaagcgt 912601 aacatatgaa aacgtgtaat ccaagaggat tacacgtttt tttaacggcc aggctctaag 912661 tcctccagca tttccatcat cgtgttgtcg tccatgacat tcattgcgtt ttgttcaaaa 912721 tgaatgggtt cagcataatg cggctgtctt tttttcgcgg ctgtctcagt ttgcctagtt 912781 tgagactgtg tatgctgatg ctgtggttgc tgctgtccag cgtgctggtg ctgacggcca 912841 ttttgccgct ggctttgatg ctgcgaacgg tcctggttat caccgctgct tccgctgctt 912901 ccgctaaatg cttgtttgac catgtttcct acattagaag catcaaacgt gttattttct 912961 gaatttcgtc tgttcatttg tcctgtgata aacccgctga ttctttggcg gatctgaggt 913021 gataatgcag taataagcat agttgatcct atgatcaatg ctgcggggct gattcctctt 913081 cgctggttga acaacatgat ccctcctttg cagtgtattc atattttccc cctcgttaga 913141 caaattaacc gttatatttc ccgggaaagc atttcctcca gatttgcatg cataattaaa 913201 gccagttaga aaaacctata agtaaagtga taaaggagga attcacatgt ttggaaaaaa 913261 acaagtcctt gcgtctgtgc ttcttatccc tttgcttatg actggctgcg gtgtagccga 913321 ccaaggtgag ggcagacgtg ataataatga tgtaagaaac gtaaattatc gaaatccggc 913381 caatgacgat atgcggaatg taaacaatcg ggataacgtt gacaacaatg ttaatgataa 913441 tgtcaataac aatcgtgtaa atgacgataa taacaacgac cgaaaacttg aggttgctga 913501 tgaagcagct gataaagtaa cagacctaaa agaagtaaag catgccgata tcattgtggc 913561 tggaaatcaa gcctacgttg cagtcgtttt aaccaatgga aataaaggtg cagtagaaaa 913621 caatctgaag aaaaaaatag ccaaaaaggt aagatctact gacaaaaaca ttgataatgt 913681 ttacgtttca gctaaccctg attttgtaga gcgtatgcaa ggatatggaa agcgtattca 913741 aaatggtgac ccaatcgccg gattatttga tgaatttaca caaactgtac agcgtgtatt 913801 ccctaacgct gaataaatga aagaagccgc acaatttgtg cggctttttc tttgcgttaa 913861 tgacacactg cgaactcagg ctgcatagag taaaaataaa aaggtacaag acggaccggc 913921 tcagggaggg agacgtttgc gggatggcat aggaaagcgt gcggcatccg ctctattcct 913981 gtgcggagtc cttgtgatgc tggctgtaag ctcagccatc gtatcaagcg cgatgtatat 914041 cctgtctttt ccaggtcagg catctggaat aacaaaagaa caagtgacga agcacatgaa 914101 gaaagagtca ttcaaacagg ccgatattta ttacacttct aaggaaaagt ccttactgcc 914161 attgacgaaa gaaacgcttg aatatgcggt cagtattaat cagattatga ttggatattc 914221 gaatcaaaag cctattgaca ttattttttt tcctaatgaa aaacagatgg aggcttactc 914281 cggtttattg gatgtagttg gtttttattc tgaacgggag cagctgatcg gattgttgcc 914341 tgaagagaaa aagaaactgt tagaagggga cgaggtagcg gtttatttgt accagagatt 914401 gttgattcat gaatactcgc accatgcgtt tcaccagaaa ttgaaggagc ttgagacgga 914461 tcccgatgag tttccgttat ggtttcatga agggttaagc gagtggattg cgaactatga 914521 attgctcata gatccgatca cgttttctgt cgtgcccttt gaccgtttgc agactgatcg 914581 agactggcag gaagctagag ccgaatatga cactgatgtc tatttgcaaa gcttttatat 914641 gatcgatgag ctgacggaca aatacgggaa agacattatt tcagaaatga ttaaggaaac 914701 ggcaaaaaaa ggggactttg aaaaagggtt taaatcagca acaaaggaaa gtcttgatca 914761 atttgaaaaa gattttaaga aaaaatttga aaaaaacagt gcggcattgg atagtatcta 914821 tccaatgcct ttgttattag tgaagtcctt gctgacccat tccgccttgt gtcggaggca 914881 tttgtccttg ggcaggggcg aatgaatttc gcagctgttc catatcctgc gcatcaagct 914941 gaggaacctg gtaatagccg tgtttgtttt ggtataggaa aatttcaaat gccatttcaa 915001 catactcctg aatttgcgca gacagtacgc gtcttacggc cggatttgtc atttccagag 915061 aagccatcgt cagcatagaa gcttgtgctt taatcgcgca aagcatttgt cggctgatga 915121 tgctgtcatc aatatcattc atggattgaa caggtttttt aggctgtgac ggctgcatgc 915181 cgtaaacagt ctggttgtct tccttcatca tataagttgc tgttttttgt gaaggttcgc 915241 ttcctgtttt gaagcattct gcagttatat tgtattgaga tgtgatgaat tgatgttgac 915301 gatcaaggat gtttagtaat tcttgatcct tacagaattg tctcagcatc ataaactgat 915361 caagcacagt aagtgttccg gaaagcacct catgcatatc aaacatttca tgtccgccgt 915421 ggtttttatg cggtttgcca ggaatacctt tgttcatttg ggattgctgc tgctgattga 915481 actgatccaa accgaattcc tccttttttt tcagatcagc tgtattttgt gtcagtctgc 915541 cgtgtattat gcagaagcct gaaaggaatt atatgctgtc tgtcgaaatg ataagcagac 915601 aaaatcgttg tcattatgtg tataagggag gaaatatgat gaggcgtatt ctgcatattg 915661 tgttgatcac ggcattaatg ttcttaaatg taatgtacac gttcgaagct gtaaaggcag 915721 ctgaaccgca acagcctata tcgattgaga aggcaataca gcaaaaagaa ggacaggcac 915781 ttgtcgaagg atatgcagtc ggccaggctg tttccccgca gcattataaa ctgacaagcc 915841 ctttttcaaa tgattataat gttgcgctgg cagaccgtaa aaacaaaaca tcgcccgaac 915901 acatccttcc tgtgcaaatc ccctccgcct tcagaagcca atttgggctg caaaccaatc 915961 cgcttcttct tgggaaaaag ataacggttc aaggaaagct tgaaaattac tttaacacga 916021 caggacttaa aaacgttcag tcgatgaacg taaccgatga cacaaaaact ccgccggctg 916081 aacagcaagt gaccataaat gaagcacggg gaaggctgaa tgaagaagta acgataaaag 916141 ggatcattac agctgatcaa aacgcaatcg gaggcgggaa gctgtcgacc tttttgcaag 916201 atgaaaccgg aggcattaac atttattcgc catcccctga acaatttccc gaattaaaag 916261 agggtatgga tgtcacggtg acagggaaaa tcacgtctta ccaggggctg aaagaaatcg 916321 ttccaaactc atcaggcatc aaaatcaacc agtcaaatca atccctcccc gcccccaaac 916381 acttaacaat caatgaactt attaacggca gcctaggtga tcagtatgaa ggacgccttg 916441 tgaaactaac cgcttttgtt tcctcaattc caagttctcc tgccggcggc ggttacaatg 916501 taacaatgat tgatgacgac catcatgcaa tgacgctccg ggttatgaat gaaacagggg 916561 tgataaacga gcttgatgag ggcaaatggt atgaatttac cggtgtgtta agcagatacc 916621 aaacctttca gctgcttccg cgaaaatcgg ctgacctgaa gctgcttgaa gagcagcccg 916681 cacctccgtc tgcagaggga gaatatgaag ggattgttga ccgggtagtt gacggcgata 916741 ccattcatct taaatctccg gtgcttggaa cgacaaaaat ccggtttgta aatgtagatg 916801 cacccgaaac atatcacaca ccaaaaaatg acgcagatga aaatcaatta agatttggca 916861 aaaaagcatc tgactatcta aaaacggttc tgtccccggg tgataaaatt actgtcaagg 916921 tcgggagtga agccaaggac agctatggca gattgctcgg acaagtcata accgaatcag 916981 gttcaaacgt gaacttagag cttgtaaaaa acggctatgc tccgacgtat tttatttggc 917041 cggttgacaa tgaagaggat tatcagcaat ttcaggccgc agtagccgct gcaaaaaaag 917101 atcaaaaagg aatttggaat gaaaacgatc ccctcatgga aatgccgttt gaattcagag 917161 ccagagagca agggaaaggc ctgacaagat atgtggggga ctcgtcgaat aaaacatatg 917221 tgcagccagc tgactggaag aagatagctg tggaaaacag aattttcttc gcctcagcaa 917281 gtgaagcgga gagcgcggga tataaaaaaa ggcaaacggc acctcaagaa catgtgccgc 917341 ttagaattct cagcatgaat gatttgcatg gcaaaatcga tcagcaatat gagcttgatc 917401 ttgatggaaa tggaactgta gacggcacgt ttggacgcat ggattatgcc gccgcatatt 917461 taaaagaaaa aaaggctgaa aagaaaaact cgctgattgt gcacgcggga gatatgatcg 917521 gcggaagctc tccagtttcc tctcttcttc aggatgaacc gactgtagaa ctgatggagg 917581 acatcggatt tgatgtcgga accgtgggaa accacgaatt tgatgaaggc acggatgaac 917641 ttctgaggat cttaaatggc ggtgatcatc cgaaaggcac aagcggatat gatggacaga 917701 actttcccct tgtatgtgcc aattgtaaaa tgaaatcaac tggagagccc tttttgccgg 917761 cttacgacat cattaatgtg gagggcgtac ccgttgcttt tatcggagtt gtcacacagt 917821 cggcagctgg catggttatg cctgaaggaa taaaaaatat cgagtttaca gatgaagcaa 917881 cagcggtgaa taaggcggcc gaagagctca agaaaaaagg cgtgaaggcc atcgcggttc 917941 tcgcacatat gtcagctgaa caaaacggca acgccattac cggtgagtct gctgatcttg 918001 caaacaaaac agattctgaa attgacgtga tttttgccgc gcataatcat caggttgtta 918061 acggtgaagt gaatggaaaa ctgattgttc aagcgtttga atatggaaaa gcgataggtg 918121 tcgttgatgt agagatcgat aaaacgacaa aagacattgt caaaaagtcc gcggaaatcg 918181 tatatgttga tcaaagtaaa atcgaaccgg atgtcagcgc gtcagccatt ttaaagaaat 918241 acgaaacaat tgcggaaccg attatcagcg aggtagtcgg cgaagccgct gttgatatgg 918301 aaggggggta ttcaaatgac ggcgatacac ctcttggaaa cctgattgcg gatggtatga 918361 gagctgccat gaaaacggat tttgccctta tgaatggcgg cggcatacgt gaagcgctga 918421 agaagggtcc aattacgtgg ggagatcttt acaatattca gccgtttgga aatgtgttaa 918481 cgaagcttga gattaaagga aaagatttaa gagagattat caatgcgcaa atctcgccgg 918541 tttttgggcc tgactacagc atcagcgggt ttacgtatac gtgggataaa gaaaccggaa 918601 aagcagttga tatgaaaatg gcagatggca ccgagatcca gcccgatgcc acatatacat 918661 tgaccgtcaa caactttatg gcgacggcga caggagccaa atatcagcca atcggactgc 918721 tgggaaaaaa tccggtgaca gggcctgagg atttggaagc gacagttgag tacgtgaaga 918781 gttttgatga gccaattgcg tatacaaaag agggaagaat taagcttgct gaagccagtg 918841 atattgaaga ccctgtaaca gaagacccga taacggaaga gcctggagat gatccgggga 918901 cggaggatcc gattaaagag gatccaaggc caggtgaaga tttgcctgat ataaaagaaa 918961 ctccgggaac agcaccggtt catcagcttc cgccttcagc catttcgaga ttcaatgaaa 919021 taccaatcaa caacacaaaa accgctgata ctgctaatag catcagcaca ttgccgttac 919081 aaaccgagac tgcggaaagc gggtctgatc atcagcttcc ggatacgtca gcgggctact 919141 ataactttat ggtaatcggt gcggcggtga cattgtcagg aacttatcta tatgtcagaa 919201 gaaaaaggag cgcctccaga acgtgaaaaa agttattcca ctattcatca ttgctgccgg 919261 cctagtgatc gcaggctatg gaggctttaa attgatcgat acgaatacga aaacggaaca 919321 gacattaaaa gaagcaaagc tggcggctaa aaagccgcag gaagcttcgg ggacgaaaaa 919381 tagcacagat caagcaaaga acaaagcatc atttaagcct gagaccggcc aagcgagcgg 919441 cattttagaa ataccgaaaa tcaatgcaga gcttccgatc gtggagggca ccgatgctga 919501 tgatttagaa aaaggtgtcg ggcattacaa ggacagctat tatcctgatg aaaacggaca 919561 aattgtgctg tcagggcatc gggataccgt gtttcgccgg acgggagagc tggaaaaggg 919621 ggatcagctc cgtcttctcc tgtcatatgg agaattcaca tatgaaattg taaaaacaaa 919681 aattgtcgat aaggatgaca catctattat cacgctccag catgaaaagg aagagctgat 919741 tctgacgacc tgctatccgt tttcatacgt cggaaatgcc ccgaagcgct atattatata 919801 tggaaaacga gtgacttaaa aagccgaggc agtgcctgcg gcttttcttc atgaaaaata 919861 tgtgcggcaa aggtttttca tatcagcagg gaaaggggct tcagcaacta tgagctcgtc 919921 tgttatcggg tgaaccgctt gtactttatt ggcgtgcagt gcctgcctgt ttagcagctt 919981 gctcccgcct ccgtaaagcg agtctcctgt caacggatgg ccgaggctcg ccagatgaac 920041 acggatttgg tgtgttctgc ctgtttccag ctctaattca acgagcgaca gccgttcttt 920101 cgcattgctg gccattacct tgaaatgagt gacggctgtt tgcccgcctg gtgaaacccg 920161 gcgtcttgtc gggtgtgagc ggtctctgcc gatcggtgaa ttaattgtcc cttttttcgt 920221 ccgtagctta ccttcagcga tagcggtata cgtacgcttc agcgtctttt tctctaactg 920281 ctggtctaag atggcgtgtg ccaaacgatg cttggcaaaa acgatagcgc cagatgtatc 920341 ctgatcaaga cgatggacgt ggcgcacctt acatgtttcg ccatttatct gataatgata 920401 cgcgatcaaa ttagccagtg tgccggtttg cccatcctca ttcggatgcg tcgcgatgcc 920461 agcgggttta ttgatgatga gcatatgatt gtcctcaaat aaaatatcaa gctcgccata 920521 ctccggaatg accgaagatg cttcactttc ctgaagatca atgaacacgc ggtctccctt 920581 ttttacaatc atattgttta agacggattc gtgattgacc tttatctgtt gatgggacat 920641 ccagtcttgt atcactggtt tagaagcttt gagcgctgtt ttgagtacgg aaaacagcca 920701 ttggccgtcc tgtttttcat tgatgaggat ctcaagccct ctgccttttt ggttcatgtt 920761 aaatggctcc ttttcgaagc ggaaggctgc tgtttctcat aggaaacact taccttagct 920821 ttcgcgtttt tttctgtgct attcttgagt aagacttagg atattcgatg gcaagaaagg 920881 tgattgacgt gagaattgtg aacgcagcaa ctgcagaaca ggagagcttt atcaaggagc 920941 tgtctatgga gctgatccat gatgtatttc ctctttattt ctccgaactg gacattcagc 921001 gctttaaaaa gaaaggcgtt ctgtctttaa ataaccatta ttaccaagga acattaaaag 921061 aagcatttca aattatggct tgtctgcaaa tgatacatat tatcctgacc aagccttcgc 921121 cgcactctga tttgagtgat caggcgattt ttgaaaaaaa cagcaagatg ctgaatgatt 921181 ttgggattta ttttccgttt gctttttctg actttcaaaa gaagactaac aaagcctttt 921241 tcggtcaaag aaggctgata taatcatgcg gcaagggctt ttctattttt agaaaagctc 921301 tttttgtatc agagaaatca tatcataaaa cctttcctct aactcccttt ttaaacggct 921361 cgtgtctgaa catactaatg attgaaaggg gtgctgacaa tgagttcagt taaagataca 921421 atgacaacgc aggtggcaac cgtttctccg aatcaaacga ttcaggaagc ggcttctcta 921481 atgaaacagc ataacgtcgg ggcgatcccc gttgtagagc aaggtgtttt aaaaggaatg 921541 ctgactgacc gtgacattgc attaagaact acagctcagg gccgtgatgg ccagacaccc 921601 gtttcagaag tgatgtcaac agaactcgta tcaggaaacc ctaatatgag tctggaagac 921661 gcgtcgcagc tgatggccca gcaccaaatc cgccgccttc ctattgtaga tcaaaacaat 921721 ctagtcggga tcgttgcgct tggagacctg gcagtcaatc agatgtcgaa cgagtctgcg 921781 ggatcagcgc tgacaaacat ttctcaccaa aacattcatt aataagaaag agcttgcagt 921841 gtgcaggctc tttcttcaca taaaacctta ctttttgaaa gcagacttgt ttcggggtat 921901 agtgagtgta tacatatgtc tcaattcgta ctaaaggagt tgtacccagt gattaaagcg 921961 ttaatttttg attttgacgg gcttattcta gatacagaaa cacacgaata tgaggttctt 922021 caggaaatat ttgaagagca cggctcagtg ctgccgctat ctgtctgggg aaaggtcatc 922081 ggaactgctg cgggtttccg gccttttgaa tatttagaag agcagatcgg gaaaaagctg 922141 aaccatgaag agctcacaca attgagaaga gagcggtttg ccaaacgcat ggaatcagaa 922201 aaagcgagac ctggtgtcga agcgtatttg aatgcggcaa aggatttagg cttaaaaata 922261 ggccttgcct ccagctctga ttataaatgg gtgtccggcc atttgaagca aatcggcctg 922321 tttgatgatt ttgaagttat tcaaacggcg gatgatgtgg aagaggtgaa gccgaatcct 922381 gaactctatt tattggcggc aaagaacctg ggggtatcgc cagcggaatg tctcgcgttt 922441 gaggattctg tcaatggttc gattgctgcg aaacgtgcag gcatgaagtg tgtcattgtc 922501 ccgaataaag taacgggtac cttgatgttt gaagactatg atcacaggct tgaatcaatg 922561 gcggagatgg agctcgccct attgcttgat catctgaact cacaaaacta gaaaggagcg 922621 agtaggttgt ctgagaaatt agatttgacc cggtttgaaa agaaaatggt tatccgcaat 922681 atcgaagaga aagacatcga caagattatc gatcttcaaa aggactgctt tccaggaatg 922741 gagccttgga agcgggagca tttaatcagc catttggagc attttccgga aggacagttt 922801 tgtgcagaat tcgaaggtga aattatcggt tcgtgctcaa gtctcctgat taactttgat 922861 gaatatgatg accgccatac gtggcaggac attacagatg acggttatat caccaaccat 922921 aatcctgacg gcttgaatat gtacggaatt gaagtcatgg tgcacccgaa atacagacga 922981 atgaagatcg gccaccgttt gtacgaggcg agaaaggact tagccagacg cttaaacctg 923041 aaaagcatca tcataggcgg acggattcca aactatcaca aatatgcaga ggaaatgaca 923101 gcgagagagt atgttgaaca ggtgacacgc caccaaattt acgatccggt tctttctttt 923161 cagctgatga acggctttac ccttatgcga attaacccga actatctccc ggatgataca 923221 gcttcgatca agtatgcgac gctgatggaa tggaataatg tcgattatct accgcagcag 923281 acaaaacgct attataaatc ggcgttccct gttagaattt gtgtgatcca atacgaaatg 923341 aagaaaattt attcctttga ggaatttgcg aatcaagtag aatactatgt cgatgttgct 923401 tccgacgcaa gatctgattt tgcggtgttc ccggaaattt tcacaaccca gctgatgtcc 923461 ttccttgagg aacggtcacc gagcttggcg gtgcagagaa ttaccgagta tacagaagat 923521 tacatcagcc tgtttactga cttggctgtg aagtataacg tcaacattat cggcggatct 923581 catttcgtcg aagaggaagg caagatctat aatatcgctt acctgttcag acgggacgga 923641 acgatcgaga agcaatacaa actccatatt acgccgaatg aacgcaaatg gtgggggatc 923701 agcgcaggag accaagttcg cgtgtttgat acggactgcg ggaaaatcgc gatccagatc 923761 tgttatgaca ttgaatttcc tgagcttgcc cggattgcgg ctgataaagg agccaaaatc 923821 atctttacgc cattttgtac agaagaccgt caaggctatc tgcgtgtcag atactgttcg 923881 caggctagag cggttgaaaa tcaaatttat acggttatct ctggaacggt cggaaacctt 923941 ccgcaaacgg aaaacatgga tatccaatac gcccagtcag gcatctttgc cccgtctgat 924001 tttgaattcg cccgagacgg cattgtcggc gaaacaaacc cgaatattga aatggtcgtc 924061 atcggcgatg ttgacctgga aattctcaga agacagcgcc aaaacggtac agtgcgccag 924121 ctaaaagaca gacgacgtga tatttatcat attcaatata aaaaataatt cccaaaaaac 924181 ccgcctgaat tggcgggttt ttttaaacaa aagcggaatt gtttaggtgc tttctttaaa 924241 ataaaagtaa attgtatagt ggatgtgcct tatggagttt ctgtattttc gccatttcct 924301 atatcataca gaaaacggct aggcttcaca ttgctattgc aatggctgtc caagttgttt 924361 cgagtgcgac ctttatcagt acgatgctga gcattgtcac tttgcctgtt ttgctttgga 924421 agctgcatcc tctttcttct tgagaaaggg gatgttttat tatttacgcg gtttattgac 924481 tctgacccgg tctggcttta tattgaaggc agggaaatca tcaccaagac atcacataaa 924541 gagaaggtct gtttcaattg aattggcatt atagggaacg ctaatgaaat ggagatgatg 924601 gggatggaaa acattcagca aaatcaggga ttaaagcaaa aagatgagca atttgtgtgg 924661 catgccatga agggagcgca tcaagcggac agcctgatag cccagaaggc cgaaggggcc 924721 tgggtaaccg acacagacgg acgccgctat ttggatgcga tgtccggttt gtggtgcgtc 924781 aacattggtt acggcagaaa ggagcttgcg gaggctgcct atgagcaact aaaggagctg 924841 ccttactacc cgttaacgca aagtcacgca cccgcaattc aactggcgga aaagctgaat 924901 gaatggcttg gcggcgatta tgttattttt ttttccaaca gcggatcgga agcaaacgaa 924961 actgctttta aaattgcccg ccagtaccat ctgcaaaacg gcgaccacag ccgttataaa 925021 ttcatctcaa gatatcgggc ataccacggc aatacattgg gagcgctctc agctaccgga 925081 caggcgcagc ggaaatataa atacgagcct ttgagccaag ggttcctgca tgcagctccg 925141 ccagatatat accggaatcc tgatgatgca gacacgcttg aaagcgcaaa tgaaatcgac 925201 cgcatcatga catgggaatt aagcgaaacg attgccgggg tcattatgga gcccatcatt 925261 acaggcggag gcatcctaat gccgccggac ggatatatga agaaggtgga ggacatttgc 925321 cggcgccacg gagccctttt gatttgcgat gaagtgatct gcgggtttgg acggacaggt 925381 gagccgttcg ggtttatgca ctacggtgtg aagcctgata tcattacgat ggcaaaggga 925441 atcacaagcg cgtatctgcc attgtcagcg actgctgtga aacgggacat tttcgaagcg 925501 tatcaggggg aagctcctta tgaccgtttc cgccacgtga acacgttcgg cggaagcccg 925561 gctgcctgtg ctttggcgtt gaaaaacctg caaattatgg aggacgaaca gctgattcag 925621 cgatcccgtg atcttggagc aaagctttta ggtgagcttc aagctctgag agaacacccg 925681 gcagtcgggg atgttagagg aaaagggctg ctgatcggaa tcgaactcgt caaagacaaa 925741 ttgactaaag agccggctga tgccgccaaa gtaaaccaag tggttgcggc gtgcaaagaa 925801 aaagggctga tcatcggcaa aaacggcgat acagtcgccg gctacaacaa tgtcatccag 925861 cttgcgccgc cattttgcct gacagaagag gacctttcct ttatcgtgaa aacggtgaaa 925921 gaaagctttc aaacgatata atataaaagt gaattattaa aggagcacat gatgagtttt 925981 cacaaccagc cgatcttacc ggctattcgc aatatgaagc aatttgatga gtttttgaac 926041 agttcattct cttacggtgt tattcttgat attcatctcg gccagctgaa gggcgtgatc 926101 aaagaagcgc aaaagcacgg aaagaacatg atggtgcacg tcgatctcat tcaagggatt 926161 aagcatgacg aatacggtgc ggaatttata tgtcaggata tcaagcccgc tgggattatt 926221 tccacaagat cgaatgtgat tgccaaagcg aagcagaaga aaatttatgc cattcagcgc 926281 ctgtttttgc ttgatacaag cgcgatggag aaaagcatgg agtttatcgg caagcataag 926341 cctgacttca tcgaagtgct tcccggcatc gttccgtcac tcattcagga aataaaagag 926401 aaaacaggga ttcccatctt tgccgggggt ttcatccgta cggaagagga tgtagagcag 926461 gcattgaaag cgggggctgt agctgtcaca acatctaata ccaaattgtg gaaaaaatat 926521 gaaaactttt tgacggaaag tgattgacac cgctttcatg cactgataca attgcactag 926581 gttaatacat tgtgatggag aactcggaga ccacagcagc tctttacggc aaatgtttat 926641 gcacccgtaa agcggtttgt tgtggttttt ttattctctt cttctctatc atgcttttta 926701 atcgtgactt taggaggaat gtgctatgac agcattttgg ggagaagtca tcggtacgat 926761 gctgcttatc atttttggtg caggtgtttg tgcaggtgtc aatttaaaga aatcgctttc 926821 attccagtct ggctggattg ttgttgtatt tggatgggga ttgggtgttg ccatggcggc 926881 atacgcggtt ggcggcatca gcggtgccca tttgaatccg gcgctaacga tagcgcttgc 926941 atttgtagga gattttcctt ggaaagaggt tccggtttat attgcggcgc aaatgatcgg 927001 agcgatcatc ggtgcggtga ttatttatct gcattacctc ccgcactgga agtcaacgga 927061 tgatcccgct gccaagctgg gtgttttctc aacagggccc agcattccgc atacatttgc 927121 aaacgtttta agcgaagtga ttgggacatt tgtccttgta cttggaatct tggccatagg 927181 tgcaaatcaa tttacagaag gacttaatcc tttaatcgtc ggtttcctca ttgtagcaat 927241 cggtatttct ctgggaggca ccaccggcta tgctatcaat cctgcacgtg acttaggtcc 927301 gcggatcgcc cacgcttttc ttccgattcc ggggaagggc tcatcaaact ggaaatacgc 927361 atgggttccg gtagtcggcc cgattttagg cggatcattc ggcggtgtat tttacaacgc 927421 tgcatttaaa gggcacatca caagcagctt ctggattgta agcgttatat tggttgtggt 927481 attgttagga ctctatgttt atacgaaatc acattctgct aaaacattat caaattctaa 927541 atatatttaa tcaaagggga gacatcttat ggaaacgtac attttatcct tagatcaggg 927601 gacgacaagt tcaagagcga ttctgtttaa taaagaaggc aaaattgtcc actctgctca 927661 aaaggaattt acacaatact tcccgcatcc tggctgggtt gagcataatg ccaatgaaat 927721 ttggggctct gtcctcgcgg ttatcgcctc agtcatctct gaatcaggaa tcagcgcttc 927781 tcaaattgcc ggcatcggca tcacgaacca gcgcgagacg acggttgtgt gggataaaga 927841 tacaggaagt cctgtctata atgcaatcgt ttggcagtcc agacagacgt ccggcatttg 927901 tgaggaactt cgtgaaaaag gatataatga taaattcaga gaaaaaacag ggcttttaat 927961 cgatccttac ttctccggca cgaaggtgaa gtggatttta gacaatgtgg aaggcgcaag 928021 agaaaaagcg gaaaaaggcg agctgctgtt tggaacgatt gatacgtggc tcatttggaa 928081 aatgtcaggc ggaaaagcgc atgtgaccga ttactccaat gcctcaagaa cactgatgtt 928141 taatatttac gatttaaaat gggacgatga actgctcgac attctaggcg taccgaaatc 928201 catgctccct gaagtgaagc cgtcctctca tgtgtatgcg gagactgttg attatcactt 928261 cttcggaaaa aatatcccga ttgctggagc ggcaggcgac cagcagtccg cattgttcgg 928321 ccaggcatgc tttgaagaag gcatggggaa aaacacttac ggcacaggat gtttcatgct 928381 gatgaatacc ggggaaaaag caattaagtc cgaacatggg cttttgacaa caatcgcttg 928441 gggcattgac ggaaaagtga actatgcgtt agaagggagc atttttgtcg caggctctgc 928501 catccagtgg cttagagacg gtttgagaat gttccaggat tcatcgctaa gcgaatctta 928561 tgcagaaaaa gtggattcaa ctgacggcgt gtatgttgtt ccagcatttg tcggactggg 928621 aacgccttac tgggacagcg atgtgcgcgg ttcggttttc ggcctgacaa gagggacaac 928681 aaaagagcac tttatccgtg cgacactgga gtcattggct tatcagacca aagatgtgct 928741 tgacgcaatg gaagcagatt caaacatttc attaaagacg ctccgtgtag acggaggagc 928801 tgtaaaaaac aatttcctaa tgcagttcca aggagacctg ttgaatgttc ctgtggagcg 928861 cccggaaatt aatgaaacga ctgcacttgg cgcggcttat ttggcgggta tcgctgtggg 928921 attctggaag gaccgttctg aaatcgcgaa ccagtggaat ctggataaac ggtttgagcc 928981 tgaattggaa gaagaaaaac gaaatgagct gtataaaggc tggcaaaaag ccgtgaaagc 929041 agctatggct tttaaataaa gtaatactat ggtataatgg ttacaagtta ataagaacgg 929101 tcctgagatg aggagagacc acagcaccaa agtgtaagca tgcactttgg ctgttgtggt 929161 ctctttttct atttaccgtg acaacaagga ggaaacgtaa tgatgaatca tcaattttca 929221 agtcttgaaa gagatcgcat gctgacagac atgacgaaaa aaacatatga cctatttatt 929281 atcggaggag gaattacagg agccggaaca gctcttgacg cggcatcaag gggaatgaag 929341 gtcgcactaa gcgaaatgca ggactttgcg gcgggaacat caagccgatc aacgaagctg 929401 gtacatggcg gcttgcgcta tttaaaacaa tttgaagtga aaatggtcgc tgaggtagga 929461 aaagagcggg cgattgtgta tgaaaacggc ccgcatgtca ctacaccgga atggatgctg 929521 cttccgtttc ataaaggcgg cacattcggt tcatttacaa catctattgg gttaagggtt 929581 tatgacttcc ttgcaggtgt gaaaaagtca gaacgaagaa gcatgctttc agcaaaagaa 929641 acgctgcaaa aagagccttt ggtgaaaaaa gacggcttaa aaggcggcgg gtactatgtg 929701 gaataccgca ctgacgatgc gagactgacc atcgaagtca tgaaggaagc ggttaaattc 929761 ggggcagagc ctgtgaatta ctccaaagtg aaggagcttc tttacgaaaa aggcaaagcc 929821 gtcggcgtat taattgaaga tgtgctgaca aagaaagaat ataaagtgta tgcgaaaaaa 929881 attgtcaatg ctacaggccc ttgggtcgat cagctcagag aaaaagacca ttcgaaaaac 929941 ggaaagcatt tgcagcatac aaaaggcatt caccttgtat ttgaccagtc tgtctttccg 930001 ctgaaacagg ctgtatattt cgatacacct gatggccgga tggtatttgc gattcctcgt 930061 gaaggcaaaa catacgtggg aacaacagac actgtttaca aagaggcgct ggagcatccg 930121 cggatgacaa cggaggatcg tgattatgtc atcaaatcaa tcaattacat gttcccggaa 930181 ctgaatatca ctgcgaatga catcgaatcc agctgggcgg ggctgcgtcc gctgattcat 930241 gaagaaggca aagatccttc tgaaatttca cggaaagacg agatttggac atctgactca 930301 ggcctgatca ccattgccgg cggaaaactg actggataca gaaaaatggc ggagcacatc 930361 gttgatcttg tccgtgatcg cttaaaagaa gagggcgaaa aggattttgg accatgtaaa 930421 acgaaaaaca tgccaatctc tggcgggcac gtcggcggtt cgaaaaatct tatgtccttc 930481 gttaccgcga aaacaaaaga aggaattgca gccggtttat cagaaaaaga cgcaaaacag 930541 cttgcgatca gatacggctc taacgtagat cgcgtctttg accgggtaga agcgctgaaa 930601 gatgaggccg cgaaacgcaa cattccggtt catattcttg ctgaggcaga atacagtata 930661 gaagaagaga tgactgcaac ccctgctgac ttctttgtcc gcagaacggg acgtttattt 930721 tttgatatca attgggtaag aacatataaa gatgccgtta ttgattttat gagcgagcga 930781 ttccaatggg atgagcaggc gaaaaacaaa catacagaaa acctcaacaa gcttttacac 930841 gatgcggtcg taccgcttga gcaataaatc ataacgggct gtctgcagcc cgttatttct 930901 ttttacgtgc cgaaaggggg agatctcagg ttatcaagtg acagaggcac ccgcttcata 930961 taaaataatg gcataagctg atacatagga ggacgaatat gacttggaga aagagctatg 931021 aacgctggaa acagacagaa catttagatc tggaattaaa agagcgcctt attgaattag 931081 agggagatga acaggccctt gaggactgtt tctataaaga ccttgaattc ggtaccggcg 931141 gaatgcgcgg ggaaatcggc gccgggacaa atcggatgaa tatttacact gtgcgcaaag 931201 catcggccgg gtttgcggca tacatctcga agcaaggtga ggaagcgaaa aaacggggcg 931261 ttgtcattgc ttatgattcc cgccataagt ctccggagtt cgcgatggaa gcggcaaaaa 931321 cacttgcgac acaaggcatc caaacatacg tgtttgatga gcttcgcccg acgccagagc 931381 tgtcattcgc tgttagacag ctgaacgctt atggtggaat tgtggtaacg gcaagccata 931441 acccgcctga atataacggc tacaaagtat acggggatga tggcggccag ctgcctccaa 931501 aggaagcgga catcgtcatt gagcaggtaa acgcgattga aaatgagctg acgatcacag 931561 tggacgaaga aaataagtta aaagaaaaag gcttaatcaa aatcatcggt gaagatattg 931621 ataaagttta tacagaaaaa ctgacgtcca tttctgtaca tcctgaatta tcggaagaag 931681 tagatgtaaa ggttgttttc acaccgctgc atggaactgc aaataaaccg gtcagacgcg 931741 gtcttgaagc actcggctac aaaaatgtaa cggttgtcaa agaacaggaa ctgccggatt 931801 caaacttctc cactgttaca tcgccgaacc cggaagagca tgcggcattc gaatatgcca 931861 ttaagcttgg ggaggagcag aatgcagata ttctcatcgc gacagatcct gatgctgacc 931921 gcctcggcat cgcggtgaaa aacgatcaag gcaaatatac agtgctgaca ggaaaccaaa 931981 ccggagcgtt gctgcttcat tacctgcttt ctgaaaagaa aaaacaaggc atcctgcctg 932041 ataacggtgt tgttctcaaa acgatcgtca caagcgaaat cggccgtgct gtagcttctt 932101 cattcggcct tgatacgatt gatacgctga caggctttaa gtttatcggt gaaaagatta 932161 aggaatacga agcatcaggc cagtatacct tccaattcgg ttatgaagag agctacggtt 932221 atttaatcgg ggattttgcc cgcgataagg acgccattca ggctgcgctt ttggcagttg 932281 aagtttgcgc gttctataaa aaacagggaa tgtcattgta tgaggcgctc atcaatctct 932341 ttaacgaata tggtttttat cgtgaagggc tgaaatccct gacgctgaaa ggcaaacaag 932401 gagcagagca aattgaagcg attcttgctt ccttcagaca aaatccgccg cagaaaatgg 932461 cgggcaaaca ggttgtcaca gcagaagatt acgctgtaag caaacggacg cttctgactg 932521 aaagcaaaga agaagccatc gacttgccaa aatcaaatgt attgaaatac ttcctggaag 932581 acgggtcttg gttctgtctc cgtccttctg gaactgagcc gaaggttaaa ttttatttcg 932641 ccgtaaaagg gtcatctttg gaagacagtg aaaagcgact tgccgtcctt tctgaagatg 932701 taatgaagac ggtggatgaa attgttgagt caacagcaaa ataattcaag tatgagctgg 932761 gtcattgtaa atgatccggc tttttctttt tctcatccaa aagtctgaaa gaaaatcatc 932821 ctacaagtga agcaatgaaa tacaaaaaac tggtataatc ttaaatacaa gatcaatgcc 932881 ggagtgagaa acgtgagcaa aacgaggatg gaaaaattaa aaacgctgaa aacgattgcg 932941 gaaaccttaa atcaagggca cgatatcaaa gcaacactgg atgaggtttt aaaagagttg 933001 ctgagtctga caaaccttca atccggatgg atttttctga tcgaagaaga tgggtcttat 933061 acgttagcgg ccgacgctta tctgcccccg gctttaagcc gcaaggaaaa agtgctgatg 933121 tgcgaagggg agtgttactg cctgacgaaa ttcaataacg gagggcttag aaaagctgca 933181 aatatcatga actgcaaacg catcgaatca gcagaaaacc tgcattgttt tgacacagaa 933241 gggattacgc atcatgcaac tgtgccttta gaagacgggg acagaagatt cggattgtta 933301 aatgtagcgg cggccggaaa aaccatgttt gatgaggaag agctgcattt actcgagtct 933361 gtcgcctttc agatcggaac ggcaatccag cgtatgaggc tttctgaata tcaacaaaaa 933421 aatgctcttt taatggagcg taaccgcctc gctcaggagc ttcacgattc agtcaatcaa 933481 atgctgtttt ccgtcagttt aactgccaaa gctgcgaaga cactaacaaa agatgaaaat 933541 ttacagcaga tgattgattt catccaaaac ctatcacagg acgcgctcgc agaaatgaaa 933601 gcgttaattt ggcagcttcg ccccggagga ttggaaaaag ggctggctga agccattaaa 933661 agctatggtg cgctcattgg attgaagatc atttttacac aaaaaggctg tcctgttctg 933721 actgatgagc aggagcatat gctatggcgt gtcgtacagg aagctttaaa taactgcaaa 933781 aagcatgccg gaacggatac ggcgtatgtt agtctgactg cttctttgtg ccatgcggag 933841 ctggatatca tcgatcatgg ggcaggattt cgctatgaag cgcatgccgg tctgccttca 933901 cttggcataa aaggtatgaa agagcgagcg gaaaaagccg gagctaagtt ttggattgag 933961 tcagcgcttg gaactggaac aaagctgtcc atcaggcttc cgctaaaaag ccgaaaagga 934021 ggggcggtat gaaaattgtc attgctgatg atcatcatgt tgtcagaaag ggtctgcgtt 934081 ttttctttgc cacccaggat gatattgaag tcgtcggaga agctgcaact ggattagaag 934141 ccctccgtgt catcgaagag acaaagccgg atcttgtgct aatggatttg tctatgcccg 934201 agatggacgg cattcaagcc attaaaaaag caatacagca atttccggat acgaatatca 934261 ttgtgctgac gagctactct gatcaggagc acgtcatccc cgcgcttcag gcaggcgcga 934321 aggcgtatca attaaaggat acggagcccg aggaattggt gaaaacacga caagtgcatg 934381 gtggcgaata caagctttct acagctatta tgccccatgt gctgacacat atgaaaaatc 934441 agcacgaccc ggaaaaagaa aaatactatc aattaactag aagggaaaaa gacgttctga 934501 ctgaaatagc gaacgggaaa agcaataaag aaatcgcagc agccttgttt atttcagaaa 934561 aaacagtaaa aacccatgta tcgaatcttt tagcaaaact tgaagtggcc gatcgcacgc 934621 aagcagcgct tttcgcagtg aaatataacc tgaatggaga gatctcaaaa tgaacatgtt 934681 agtcataaat ggcacgccaa gaaaacatgg cagaacaaga attgcagcat cctatattgc 934741 agctctgtat cacacggatt tgattgatct aagcgagttt gtattgcccg tttttaacgg 934801 tgaagcggaa caatctgaac tgttgaaagt acaggagctt aagcaacgcg ttacgaaagc 934861 ggatgcgatt gtattattat cgcctgaata tcacagcggc atgagcggcg ctttaaaaaa 934921 tgccttggat tttctaagca gcgaacaatt caaatataag cccgttgcat tattggcagt 934981 agcgggaggc ggaaaaggcg gcatcaatgc gctgaacaat atgagaactg tgatgcgggg 935041 tgtctacgcc aatgtcattc cgaagcagct ggtgcttgat ccggtgcata ttgatgttga 935101 aaatgctaca gtggctgaaa acattaagga aagcataaaa gagcttgtcg aagaactcag 935161 catgttcgca aaagcaggaa atcccggcgt ctaaacgccg ggatttgttt atgtgagaag 935221 ggctatttga tcttcataag tcagctctgt ggcatgatca atatatcgga gaagggaata 935281 cagcatcttt tctaaaacgg cgtaatcctg ttcaaaatga tacgcatgca gaaaatgctc 935341 aattcgtttt gataacaaat cgtcctctgt acgcaccatt aaaattaata aattatccca 935401 ttgagaacga tgggtgtaat aaagcgcttt atcgtaatcg gcataatcca tgaatcgctt 935461 ctcctttctt gggtgagaag ttcatgatta gtttatgccg catcctctgt tattgacggg 935521 gcaaaacttg ccgtctgcgt cagtaaaggg gtagcaatat gagggagaca taaaatcaaa 935581 atgcctgaat gaagatatcg cttttggtaa acctatgagg gaatatattc tgggtacagg 935641 agactgaaaa aatgaaatcc ctgccgtata ccatcgcact tcttttttgc ggattgatta 935701 tcgtgtcaat ggctgcaaaa ggtcattcaa cggacacaga cgagtccgtt caaaagtggg 935761 aacagcttgc ctggagcaaa attcaggatg aatataaggg cgcttcattt tctgattatg 935821 cttatatggg gcgtacagag gtgaatgatc agcagactaa agatgtcttt cgggtgacag 935881 tcagacagaa agatgacact ttttctgttc gggccgaagt ctattttcat ccggtgacaa 935941 atcatatgat cagcatcaac gtctttaggc tctaataaaa aactgtacag ccgttaaggc 936001 cgcacagttt ctgtttttag aaatatcgtt ttgcaccgag atagcgctgt ttccagtaag 936061 agttgttcat attggaaatg acaactccgg aatcgttggc atttatgaat tccccgttgc 936121 ctaggtaaat tccgacgtgg gaagggccgg ctttatatgt tgaaaagaaa acgaaatctc 936181 cgacagcagg ctggctaact gatttcattg tgttccaata tcccgctgcc gttaatctag 936241 atacggatgt gactttgttc agtacatagt aaatgaatcc gctgcagtca aacccggacg 936301 gtgtcgtgcc tccccagcga tacggaaccc caagctgcgc tttagcggcc gaaatcattg 936361 tgttaatctt cgcactcgtt gagctggtgg tgtttgaaga accggatgaa gacgatgatg 936421 aagcttttcc ggaaatgacc agcttttggc caacctgcaa gacatccgtt tttaaattgt 936481 ttttctcacg aatctgctga gctgttacat taaatttttg agcaatcacc cataaggaat 936541 caccgctttt caccgtgtat gtagtcgtcg tgccggagct tgcatttgac gaagaagacg 936601 acgatgatga agagcctgaa gatgctttac ctgtcagctt caatacttgt ccaacgtaaa 936661 gcacatctga tttcagattg ttgatatttc ggatttgctg tacagtcagg ttatagttgt 936721 ttgcgatttt ccaaagtgaa tcaccgcttt taacggtata tttagttgtt gctgaagttt 936781 ggttcgattt ggatgaattg tctttagaag acgtatcaga gccgcttgat tttgttttca 936841 acacctgatt cacgtaaatg gtgtctgatt ttaagttgtt caagaccttc aattcagcga 936901 tggacatatt gactttgttt gcaattttcc aaagtgaatc tccaagctgc accttatatg 936961 ttcccgtaga agatgaagaa cttgaactct tattagaact gctttttgaa ctggagcttg 937021 aactcttatt agagttgctt tttttactgg aactagagct tgaagaaaca gtaccggaca 937081 cctttaattt ctgcccagca cgaattaaat cgctgcttag tccgtttaat tttttcagtt 937141 cctgcaccgt cattttaaac tcatttgcga tcagccaaag tgaatctccg cttttcactg 937201 tgtaaacaga acttccgctc ttcttggttg ttgagcttga agtagatgaa gaagtgctgg 937261 atttgctgcc tggaatagta agcgtctggc cgatcgacag aacagtagtc gaaagatgat 937321 tggcggatgt gagggccgcc acacttgtgt tataggtttg ggccagtttc cataaagaat 937381 ctccgctttt gaccttaatc gttgctgctt cagctggtgt cactactaaa gttgtgccga 937441 caatcgcaga tgctgtcagc cctgctgcta atttcttttt catcttagct ctcctttttc 937501 ccccaatgat tttgcatttg ctgtttcttt tttatatcgg cacatttgtc tcatcgtttt 937561 gcctttttat aaaaatagcc aaattatctt aacaataagg gggaaaaagg gcataaaaaa 937621 agaaggaatc ttaatctatt ccttcatttt taaaagcttc atgatatctt ctttgttttt 937681 gacgaggtcg cgcagtgtgt atttgtctaa aactgcgagg taggctaaaa gcgcttcatt 937741 cagcacatgt tttaagccgc aaaccgggga aataacacag agattcttgt tcgcatcaaa 937801 acattcaaca atattaaaat cgtcctccgt ttttctgaca acctcaccga tgttgatgtc 937861 ttcagggtcc atgcctaatc gtatgccgcc gccccgtccg cgtatcgttt ctacgtagcc 937921 gagctggccg agcctgtata tgactttcat gagatgattt tttgaaatag aatacgtttc 937981 ggcaatctgt tttatatttg aaagttctcc gggacgctct gcagccagaa aaatcaacac 938041 tcttaatgaa taatctgtat aattggttaa cttcataata agacctcaga ataagacatt 938101 ttctatatct tatcataatc gattgaaaaa tgaaaaaaaa ggaattaaaa aacatgcacc 938161 cagctgggtg catgtttttt gcttacatgt cattcggcgg attttggttt ttacggtttt 938221 tttcgatttc tgtgttttgc attttgcgtt caaatgtaga cagataacgt gatgcaaaat 938281 ccttaccgcc aaggccgaag gataaaccaa aagcaagtgc gaagccgcta agaacgatga 938341 tgaacgcgga attgacgatt gtcgcagcga cacccagctg atccagggcc ataaagaaag 938401 caagtgcgat aatcgtatat ttagcaatag gcgctaaaga cttgaattcc tgacctttta 938461 tcatgcttgc gagcactttt ctcaccaatt ctcctgcgta aaggccgagt ccgagaatga 938521 atactgcgac aaggacattc ggcagatacg cgatgatgcc ggtggcaatt tctacgagga 938581 agtgcagccg aacaatttga agcgcctcag ctgtaaagag cagaatgaca atgatttgcg 938641 caatcatacc gacaacttga gacaaggaca gctttgcagg cgttccggct tccatgccca 938701 ttttccctaa gacagaatca aagcctgcgc gatggagcag tccggacacc atggatttca 938761 cccattttcc tgcccagata cccgctaata caagcacgat ggcaatcatg atgttcggaa 938821 gcatgtttaa aatcgtattc agcatagaga cagctggttt tgaaatgccg gcgacatcca 938881 gctgatcaag cgctgaaatg accaccggaa tcataatgag cacataagcg attgttccga 938941 tgactgctga aaggcttgtg tcttttaagt aaattgataa acccatacgt gccgcgaatc 939001 tttcggtgcc gatgcttgca aggaaattcg taatgatatc acggacaagg cgggcaacaa 939061 gccatccgat taatacgata agcgccgctg caaataattt cggcagaaaa gcgagcacgc 939121 tttccatcat atttgtaaaa ggacctgaaa tgccgctgat tttcaaagaa gataagaccc 939181 ctggcagaaa aacaagcagc acgagataaa agacaatttg tgaagcggta ttgacagcct 939241 ggtgaatatc ttttccttca gacaccaaat tccacttgcg cagtttgtca ctcgtgttca 939301 gcttcatccc gatttttttg acaaggaagc tcaaaacaga agctgcagcc catcctaaca 939361 gcagaatgag tccggctttc agcacgcttg ggatcgcagc tgcaatcgcc gaaagcatac 939421 tgacaaacgg cgatgccact gttgtcaggt gcaaaatgtt aaagaataaa ataaagacga 939481 tgatcagtgc gataaaataa acgaccttgc ttatgacttt ttccgaggaa tagcgtgaag 939541 gctttttccc agcaaagagc ttgtcgtcga tttttgtttt gctgagtcct ttgtataccg 939601 ctttttcaat gattttagca atagcccagc cgattaataa gacgagtaaa gcaatgatta 939661 cgtttggcag cttactgaga taagaagaaa acacgtctgc tacattcaat tggtatcgct 939721 cctttttcgt agtatggtgt gtgtttaccc acttatccaa taagcaaaca gatgaatgtg 939781 ccgggggaat tttttcttgc ccgagtgaga ctatcatctt ttgtctggcg ggctcataca 939841 ttatagataa gtccaagtag gggggattcg gttgaacgcg gaggagaaga agggattaca 939901 gcgggcaatt gaggaaatta ccgaaattgc aaaaggattc ggccttgatt tctacccgat 939961 gagatatgaa atctgcccgg ctgaaattat ttatacattt ggcgcgtacg ggatgccgac 940021 aagattcagc cactggagct tcggcaagca gtttcacaag atgaagctgc actatgatct 940081 agggttaagt aagatctatg agctggtcat taactcagat ccatgctacg cttttttgct 940141 ggacagcaac tcactgatcc aaaataaatt gattgtcgca cacgttcttg ctcattgcga 940201 tttcttcaaa aacaactgcc gtttccaaaa cacgaagcgc gatatggtgg aaagcatggc 940261 ggcaacagct gaacggataa aacactatga acaggttcac gggataaaag aagtcgaatc 940321 ttttttagat gcaatccttt cgattcagga gcatatcgat ccgtcgttgg tccgaccaaa 940381 gctccaatgg agtgtggatg atgaggaaga ggagattgaa gaggcagcca cgccttacga 940441 tgatctatgg tctttagatg aaaagaaacc gaaaaaacaa gtgaaaaaat cgaaaaaacc 940501 gttcccgccg cggcctgaaa aagatatcct gctttttatc gaggagcatt cccgggagct 940561 ggagccatgg cagcgtgata tattaacgat gatgagagag gaaatgcttt atttctggcc 940621 tcagctggaa accaagatta tgaatgaggg ctgggcttcc tattggcacc agagaattat 940681 acgtgagctt gatttaacct ctgatgaagc gatcgagttc gccaagctga atgcaggtgt 940741 cgttcagccg tccaaaacag gcattaatcc ttattattta gggctgaaaa tatttgaaga 940801 cattgaaaag aggtacaaca acccgacgga ggaaatgaag aaaatgggcg tgcagcctga 940861 ctccggccgg gagaaaatgt ttgaggtcag ggagattgaa tccgatatct ctttcatccg 940921 caattattta accaaagaat tagtcatgcg cgaggatctt tatttgtttc aaaaacaggg 940981 ccgagattat aaaatcatcg ataaacagtg gaagtcggtg cgcgaccagc tcgtaagcat 941041 gcgggtaaat ggcggttttc catatttgac agtaaacgac ggcgattata tgaaaaataa 941101 cgaactctat attaagcatt ggtatgaggg catagagttg gatttgaaat atttggagaa 941161 agtgcttcct tatttattcc agctttgggg aagaagcgtg cacattgagt ctgtgcttga 941221 ggataaggaa gtcatgtttt cgtacgacgg aaaaggtgtt caccgcagat atttataaaa 941281 aagaggatgc agcgttctgc atccttttta ttttccagtt tttaaaatct taaatatgat 941341 gtttgcctgg tccgtattgt taatcaatcc gcggaatttt tcttttccgg ggccgtacgc 941401 gtataccggt acttcttcgc cggtatgatc ggtactcgtc catccgctgt tggagcgggt 941461 attaaaaatc ttgatgatgg ctttggaggc ccctttgctt ttgtcagcct gtgcagctgc 941521 ttcaacgctt ttgatttctt cagatgtgac tttcagattg gcatagcggg cgagcacatc 941581 tttaaccggc ttgccttcac tgattttttt ggccatgaat tcaggtgttt tcttagcgga 941641 gagaatcggt tctgcgtgcc aattcttttc cccgtttgcg ccaatggtaa agccgccggt 941701 tgtatggtca gcagttgcaa tcacaagtgt atgtttgtct tttttcgcaa attcaatcgc 941761 ggctttatag gcctgttcaa aatctttaac ctcgctcatg gctcctactg tatcattgtc 941821 atgggccgcc cagtcaatct ggctcccttc gaccatcaag aaaaatcctt ttttattttg 941881 gttcaggcga tcaattgctg aaaccgtcat gtctttgaga gacggtgttt tactgtcacg 941941 gtcgagcgct ttagcaagcc ctccatctgc gaaaagcccg agcacctgct gatctttatt 942001 ttttttcaat gcttgtttag ttgtcacata gctgtagccg gcttgtttga attcctttgt 942061 caagtttctg tccttgcggt taaaataaga ttttccgccg ccgagcagca cgtctatttt 942121 atgtttgcct tttatcttgt catccatata gctgttggcg atttggtcca tgtttttccg 942181 tgattcattg tgggcgccat atgcggctgg agtggcgtgg ttaatttcag acgtggcgac 942241 aagccctgtt gacttgcctt gctgtttggc ctcttcaagt acagatttca ctttttttcc 942301 gtttttatcg acgccaattg cattgttata tgtcttaacg cctgtcgcta atgctgttcc 942361 ggctgctgct gaatctgtaa tattatagtc agggtcatcc ggatgcgtca tcatcatgcc 942421 tgtcaggttc cggtcaaatt ctgttaactt cgggttattc ggtgtgtcac cgttattttt 942481 catggaacgg taggctctta tgtaaggcgt ccccatgccg tcgcctatca tcacaatgac 942541 atttctgatc tcagctttgt cttgtttttt ggcgctggcc ttttctgttt gctgaagctc 942601 agctccggca aagattccag ctgtaaggac agaaacagcg gcgattggca gaagttttga 942661 tttcatattt tgaaacaaac tcattttttt catgcctcct ttaatgtatt ccgtttatca 942721 tgttagggaa actttgttaa atgcggctgt tgatcatgta aacaataagt aaagccttgt 942781 aaggaaatga aaaaacgctt ttcgttatct tgccttattt gatgtaaagc attcattttt 942841 cagaaaaatc tttacctctc tgtctttgca tgatatgttt gtttaaataa aaaaactgcg 942901 gataaccaca gctctcctcg aatatacttt atcactcatt tttccgatat atgagccgac 942961 cccgaaagtt tttcatttat ttcctttatg ttgaaaaaca tcccataaaa catgacaaaa 943021 gcactcgttt tttgtcacct ttgcaatgaa aatgaaatat ttaataccct taaaaacttt 943081 tttttagaac gaataattaa gaaatttgtc acatgaagtc aagactattt ctgatgggaa 943141 tctatcctta taatagaaat caataagatt aatttaaaaa aagagataca tatatataga 943201 gttaacattt ggggaggaaa atatgaaaaa gcaaatcatt acagctacga cagcagttgt 943261 tttaggatcg acgttatttg caggagcggc atctgcacaa agcattaagg tgaaaaaagg 943321 cgacacgtta tgggatcttt caagaaaata cgacacaacg atcagtaaaa ttaaatcaga 943381 gaaccacctt cgttcagaca ttatttatgt gggacaaact ttatcgatta acggcaaatc 943441 tacaagttca aaaagcagca gttcttcttc ctcttcttct acatacaaag taaagagcgg 943501 ggacagcctt tggaaaattt caaaaaaata cggcatgaca atcaatgaac tgaagaagct 943561 gaatggctta aaatcagatt tgcttcgtgt tggacaagtc ctgaaactga aaggttcaac 943621 tagttcaagc agctccagct catcaaaagt gtcatcgtct tcaacttcta cttataaagt 943681 gaagagcgga gacagccttt ctaaaattgc gagcaaatac ggcactacgg ttagcaaatt 943741 aaaaagctta aacggcttaa aatcagatgt aatctatgtc aaccaagtat tgaaggtgaa 943801 aggaacaagc acaagcagct caaaacctgc ttcatcttca tcgtcttcaa gcagcaaaac 943861 gtcatctaca tcacttaatg tgagcaagct ggtttctgat gcaaaagcgt tagtcggaac 943921 gccatataaa tggggcggaa cgacaacttc aggctttgac tgcagcggat tcatttggta 943981 cgtactgaat aaacaaacaa gtgtgggcag aacaagcact gcaggatact ggagttctat 944041 gaagagcatt gccagcccgt ctgttggtga tttcgtcttc ttcacaacat ataaatccgg 944101 cccttctcac atggggattt acattggaaa caacagtttc attcatgcag gatctgacgg 944161 cgtacaaatc agcagcctga acaacagcta ctggaagcct cgttacctcg gtgcgaaaag 944221 attctaattt ttagagaaaa cccgttcatt ggaacgggtt tttttcatta gacggagcac 944281 aggcgttttg gttgctccta aaaatgaaaa tgtgataaaa aatccaagaa ctttttttct 944341 ttcttatttt cataaagggc aatcgcgtaa gcgccggcat agggcagctg tacagactga 944401 taaggaattc tgatcatctg tttctctgct aactcacgct ttactgtaga taaaggcaga 944461 aatgaaactc cgagtccttc cttgataaac cgtttcgtta tatgtgtttg agtgaccttc 944521 attgttctca caaatggaaa tgtcattctg acttgacgga gcaagtcgtc ccagtaatca 944581 ggatgattgt gggtcaaaag caggtattgt tcgagcacct ctttggcatc aatttcgttg 944641 tcttctatga aacgcttatc gggcggggca acaaggacga cagggtcttt gtataagcag 944701 tggcagctta aagaagaaga ctgtaccttt aaacagctta gtccgatatc tgcttccccg 944761 gctttaatca gtgacgcgat ttccgctgat tcgaaaatcg taaccgccat ttctgtttcc 944821 gtattcattg ctgtgtaccg cttcatgaca gaaggaagca ctgtatctgc aataagcgga 944881 gaaaccgcga gctgtaaggt ttgagagtag ccttgtctca ctctgtgaag ctctgccatg 944941 ctgttttcat aatcatcaag aagcctgagc gcatacggca aatacgccct gccttcatca 945001 gtcagctgga tttgcctgcc tttacgctcg aacagcttgc agctgatttc tttttctaat 945061 tgcttgatat gtacggtcac agtaggctga gataagaaaa gcgtttccgc cgtttttcgg 945121 aagttctcat attttgcagc ggtcacaaag gtgtgaagcc atttgaaatc catttctatt 945181 ctccctctga ttaatatttt taattaattc cctttaaaat attgattatt ttttaaatat 945241 tatatttact ataataacag aaaaggatag ggggaataca aatggtacat tacggattaa 945301 agggaattac atgtgtagaa acatccatca gccatattga tggtgaaaaa gggcgtctga 945361 tttacagagg acatcatgca aaagacatcg cactgaatca cagctttgaa gaagcggctt 945421 atttgatttt atttggaaaa ctgccttcaa ctgaagaatt gcaggtattt aaagataagc 945481 tggctgcgga acggaatctt ccggaacata ttgagcgctt gattcaatca ctgccaaaca 945541 acatggacga tatgtcggtg ctgagaacgg ttgtttcagc attgggggaa aatacgtaca 945601 cattccatcc gaaaacagag gaagcaatcc ggctgattgc aatcacgcct tctatcattg 945661 catacagaaa aagatggacg cgcggtgaac aagcaattgc accttcttcc cagtacggac 945721 atgtcgaaaa ctactattat atgctcacag gtgaacagcc ttcagaggca aaaaagaaag 945781 cgcttgaaac ctatatgatt ctggccacgg agcacggcat gaacgcatcg actttttcgg 945841 cacgagtcac gttatctaca gagagtgatt tagtgtcagc cgtcacggct gctctcggta 945901 cgatgaaagg tccgctgcac ggaggtgctc cttctgcggt gacaaaaatg cttgaagaca 945961 ttggagaaaa ggaacatgct gaagcatatc tgaaagaaaa actcgaaaaa ggagagcgct 946021 tgatgggatt cggccacagg gtgtacaaaa caaaagaccc gcgggcagaa gctttgagac 946081 agaaagcaga agaggtggcc ggcaatgacc gtgatcttga tcttgcgctg catgtagaag 946141 cagaagcgat tcgtttgcta gaaatctaca aaccgggacg aaagctgtac acaaatgttg 946201 aattttacgc agctgcagtg atgagggcca tcgattttga cgatgaattg tttactccga 946261 ccttttcagc aagccgaatg gtagggtggt gcgcccatgt actggaacag gcagaaaaca 946321 acatgatttt ccgcccgtca gcgcaatata ccggtgccat tcccgaggaa gttctttcat 946381 aacatatttt ggcgtttatt catttctgtc gtgtggtaac gttcagtatc aaccacatgt 946441 ctaggagtga tgaatgtgaa cccaatggac agacaaacag aaggacaaga accgcagcat 946501 caggacagac agccgggcat tgagtcaaaa atgaatccgc tgccgctgtc agaggacgag 946561 gattatcgag gaagcggaaa actgaaagga aaagttgcga tcattactgg aggcgacagc 946621 ggaataggga gagcagcagc tattgccttt gctaaagagg gggctgatat ctccattcta 946681 tacttagacg agcattcgga cgcagaggaa acacgcaaac ggatcgaaaa ggagaatgtc 946741 cgctgcctgc ttatcccggg agatgttggg gacgagaacc attgtgaaca agctgtgcag 946801 caaacagtgg accattttgg taaactcgat atcttagtga acaacgccgc tgaacagcat 946861 ccccaggaca gcattctcaa tatttcaaca gaacagctgg aaaaaacctt tcgcacaaat 946921 attttttcca tgtttcatat gacgaagaaa gctttgcctc acctgcaaga ggggtgtgcc 946981 attattaata cgacatcgat taccgcttat gaaggggata cggcgttaat tgattattcc 947041 agcacaaagg gtgcgattgt ttcctttacg cgttccatgg cgaagtcgct tgcagataaa 947101 ggcatcagag tgaatgcggt ggcgcccggt ccgatttgga caccgcttat tccggcgaca 947161 ttccctgagg aaaaagtgaa acagcacggc ttggataccc caatgggaag accgggacag 947221 ccggttgagc atgcaggcgc ctatgttctg ctggcgtctg acgaatcttc ctatatgaca 947281 gggcagacca ttcatgtgaa tggcggccgt tttatttcaa cgtaatcaac gaaaaaccag 947341 ctcaagagct ggttttttgt gtggtgaaaa atttcaaaat aaaaaatttg tcgatttttc 947401 taacaatttt gttttcattt ttgcaatttt atatataata ttgagtagga gaaaggaatg 947461 attcgcgacc agtacaaata tagtagaaaa aaaagaataa tgaccattgt tactcatgaa 947521 ttcagaaaat tcaaataaaa tatataaaaa tagatgatcg ggagttgaag gggaatgaaa 947581 gggagcgttt ttaggaagaa aagcattcag gatttaatcg ctgcgacgag cggggaaaag 947641 tctttaaaaa gagaattagg ggcatttgat ttaacgttgc ttggaatcgg cgccattatt 947701 ggcacaggga tttttgttct gacgggaaca ggcgcagtca cggccggtcc cgggctgacg 947761 atttcatttg ttgtggcggc gttggcttgt ttattcgccg ccctgtctta cgcggaattt 947821 gcgtcaagtg tgcctgtttc aggttcggtg tatacattca cttatgcgac attgggagag 947881 cttatggcct ttattatcgg gtgggattta attttagaat acatgctggc ggtaagtgca 947941 gtgtcggtcg gctggtctgg ttatttccaa tcgtttttat cagggcttgg cattcatctt 948001 ccggttgctt taacagcggc accgggcgca gtgaaaggca cctttaccct gtttaatctt 948061 cctgcattcg tcattgtaat ggcgatcaca tatttgcttt atttaggcat caaagaatca 948121 aaaagagtca acaatatcat ggttatcttg aagatactgg ttgttctgct gtttatcgcg 948181 gtggcagccg tttacgtgaa gccgcacaac tggcagccgt ttatgccaat gggctttggc 948241 ggcgtgttca gtgcagcggc gctcgtattc tttgctttta tcggatttga cgctgtatcc 948301 tctgctgcgg aagaaacgaa aaatcccgcg aaggatctgc ctaaaggcat tattttctct 948361 ttactggtct gcacgatttt atatgtcacc gtatcagcca tcatgactgg ggttatcccg 948421 tttgctcaat ttgcgggtgt ggatcatccg gtttctcttg ttcttcaaag cgcagggcaa 948481 aattgggtgg caggcatcat tgatattggc gccgtgttgg gaatgacaac agttatgctc 948541 gtgatgcttt acgggcagac ccgcgtcatg tttgccatgt cgcgtgacgg acttgtgccg 948601 ggttcacttt ctaaagtgca tccaaagcac aaaacacctt atgtagccac ttggtttttc 948661 ggaacgatgt cggcgcttct cggctcactt gttccgctgg atgaacttgc aaagctggtg 948721 aacatcggga cgttgtcggc atttgtcctg atttctgtgg cagttatcgt tttgagaaag 948781 aaacagcctg atcttccgag agcttttaaa tgcccgggag ttcccgtgat cccaggcctg 948841 gcgattctgt tctgcctgtt cttgatttta aatctgggat gggtgacgat tgtccgcttc 948901 ctagtgtggc tgttaatcgg cttggtaatc tatttcctgt attcaagaaa gcattcaaaa 948961 ttaaatcaat aaccttttga taaagagagc ggccatacag gccgcctctt ttctgttctt 949021 ggcaaatgaa tctatagaaa tgaagacaaa aataagagat aatataggct ggaaaggaag 949081 tgacgtttat tgtctgagca aaaaccagtc caatgggctt cgaaaattgg tttcgtcatg 949141 gcagcggccg gctcggctat cggcttgggc gcgatttgga agttccctta cgtagcgggg 949201 accaatgggg gaggagcctt ttttcttatc ttcgtgttat ttaccatcct cttaggctat 949261 ccgcttttgg tgggggaatt tatttttgga agacggaacc agacgaatgc cattgatgca 949321 tataaaaaag aagcgccgcg atcagcttgg tttcttacgg ggtggatcgg cgtagcggcg 949381 tgtttcttag tgctgtcgtt ttacagtgta atcgggggat ggattttgct gtatatcgtg 949441 aaaacagcgt caggatcact gtccgggctt tctcaagcac agtatggcgc tctttttgct 949501 tctattatcc aaaatccggt gcagacgctc gcggctcagc ttgtctttat ggcactgact 949561 gtactcgttg tcgcaagagg ggttcaaaaa gggattgaac gggtaagcgc ggtgatgatg 949621 ccgattttgt ttttattgtt tattctgctc gttcttcggt ctcttacgct taatggtgca 949681 atggaaggcg taaagtttct gcttgtgcct catttcggcg atctgactcc ggaatccata 949741 ttattcgcgc tgggacaggc cttctttacg ttaacactgg gggtttcggt gatggtgacc 949801 tacagctcct atttgccgaa aacacaaaat atccctcgtt cggcagcctc cattgtcttg 949861 atgaatatca ttgtgacact cttggcaggt ttggctattt ttccggcggt tttctcattc 949921 ggttttcagc caaatgaagg accgacattg ctgtttacag tgcttccggc cgtttttgaa 949981 cagcttccgt tcggcacatt gttttttatc ggctttctcg ttgcattttt atttgcagcc 950041 ttaacctcag cattttcgat ggttgaaatt atcgttgcca caatcggaaa aggggacgaa 950101 aagaagagaa aaaaactgtc atggacgagc gggcttttga tctttttggt cggaatccca 950161 tgctgcttgt cttatggcgt tttgagtgat gtgcacctat ttggcaaaac gttttttgat 950221 attgccgatt ttaccgtcag caatgttttg atgccttcag gcgctctgtt aatttctcta 950281 tttatcccgc tgaaaatttc gaaaagcgaa ctcttggctg aaatgcgaaa tggatcaaat 950341 gcaggtaaag cattctttta cacatggttt tatttgcttc gttttatcgt gccgcttgcc 950401 attattatcg tgttcttaaa tttaatcgga attttatcat tttaaaaaac aggctccgtt 950461 tccggggcct gttttttatt taataagatg atatcaacgg tgcccatgcc gttttcagtt 950521 tttggatgcc gagcctgatg tcctcttctg acaaaccgcc ataaccgatt aagacagaag 950581 taaaaggcgt ctgttctata tatgagggag acacgggata gagggttaca ccgtggtcag 950641 cggctgcttg tattgcttct tcctcacttg ctggaaacaa aaggcgcagc agaatgtgaa 950701 gccccgagtt cttaccgaga atctcaacgg tgtttcccag ttcagagcga atggcttcta 950761 acaggacagc gtgttttttt cggtataagc ttctcattct atttatgtgt ttttgccact 950821 ctccggtttc gatgaagtct gccagtgcca attgcgagtg ggcagaaacg gtctgcttca 950881 ttaactgaac attgttttgg atcggttcca tgagttcagg gggcacaatc atgaagctga 950941 gccgcaagga aggcagaagt gactttgaaa aagtgcccag atatatgact ctgccattcg 951001 gatcaagacc ctgtaaagac ggaatgggat ggccgctgta gcgaaattct ccatcgtaat 951061 catcttctat aatgaatgaa tttgtttctg ccgcccatgc cagcagctcc tgtctgcggg 951121 taatcgtcat aatggtccca atcggaaact gatgcgaagg agtcgtatac atgagataag 951181 gattctgacg gtagagctca tccggcagga cgccttctgc atcagaacaa atcggagtga 951241 catccatgtg atttgcttca aacatccttc ttgaacggtg aaagcccggt tcttcaaagc 951301 cgatttttgt acctggcttt agcgaaaggc aaagattttg cagaagcacg gtggttcctg 951361 cgccgatgat aatctggccg ggttcacaat ttactccccg agacagcctg acgaatcggg 951421 caatcatgtg cctgagttcg tattctcctt gagggtcgcc agaggtgtga aacgatccgg 951481 aatagcgatc aagacttttt actatgcttt ttctccatgc gttaaaggga aagagggtcg 951541 gatcaacgct gccctgatgg aagtcaatag caggtgcgtt tttttgatgt aatcccggct 951601 gtacagactg ctgaaaatgg tcaggagctg tcgggaatcc tggttctact tccgccgcga 951661 accagccgat tttcggcttg cttttgacat agccctcagc agttaattgc tcataagctc 951721 gttctatagt tgccgtgctg acatcgagca agctggagag cctgcgtttt gacggaagtc 951781 ttgttccctt tgtgattcgc gcatgtgaaa tttcttgttt aaaaaaggta taaagctgtt 951841 catacagcgg tgttttgctc tttttatcaa gaaacggcgt aatatccatc tcatgtctcc 951901 tttgtagctg gcatggtcat tttttctgat attggctatt tggcaaatgc catttattag 951961 ctatgatcat tgtaacgaaa ggaaagggga ttgagaagat gatccatatg aaacaattaa 952021 cctcgaaaga agaatgggct gagtcgtatc cgattatgag tgaattgaga acagaactgg 952081 atatagagac gtatttacaa aggcttgaag cctgtgtgca gaaagaatcg tatatgctgt 952141 ttgccttata tgaaaataca gcaatcagag cgctgtgcgg ggctctgccg agagtttcca 952201 ttcataaagg agagcacttg tggattgcgg atcttgttac aacggcacct tgccgatcaa 952261 agggatacgg caaaatgctt ttggattatg cctcagactg ggcgagaaaa gccggactcg 952321 gttttgtcag tctttcatct ggccttcagc gtaaagacgc acatcgattt tatacagata 952381 aaatgggttt tactatagaa agttatttgt tccgaaaacc ggtataacga aaaaagacgc 952441 ctgaaaaggc gtctttttta aaagccaaac tgtaaattcg tatctacaga tacaatggta 952501 tacacacaaa taatcacaaa gagattaagg atgacgccga gcaggcctgg acctgtgcgc 952561 cctctcttga tgaagagttc aacaacgccg aacggaacgg cagccatggc gaacggaagc 952621 atttgatagg aataaaacgt gacgttgctg ataatggcca aattcagcaa cagcagggac 952681 agaaccgctg tcccgacaga gatccagccg aatacattgt gttctttaaa aattcttacc 952741 agttccataa ttccacctcg ccgacattcg ctgattttac agatttattt ttcagcatgc 952801 gctggatttc cttggttggc cctgtaacga ccgaaccgta tacattgaca ccgtttttct 952861 ctacataatc taatcggtta tctacattca ggtctttccg ttttgaaatg acctgagccc 952921 atttttcgtg tttggacatg aatttcaggg cgttgataaa ctgatcgcca ttcgacttgc 952981 cttttgtatt aagggcggcc aagaactttg aatcctttcc aggatagcca agaggttctg 953041 tggaagctgt cttatttgtg tttttctctg tttcgattgc gttccacaaa aagctcacat 953101 catagccttt gaatttgtta tacacgtctt ttgtcggata tgcacggtca tatgaaaggt 953161 agacctctga taccgttcct tcaggcaatg tgcttaacgt tttttctgct tttgcggtcg 953221 tttgttcaga cttgtttgaa ggatgtgtaa agtaatggcc ggttttattc acttctaagt 953281 catagtagtt tactgccggc gcttttactt tgttataaaa catttcaacc cgttcattcc 953341 ctacggcagc cgtcttcgtg ccaatctgct tttgcagcgg gaattccgta ttcattccaa 953401 atagcttcac ttggcttttc agtccggaag tatcaacaag aacattcggc atggtcaggg 953461 ctacagtgac tgcggcagtt tccataaact cattgccggt gctgtgtttt ccacccattc 953521 cgtaatagag gtagcttccc agcgtacaaa gcggcaaaat catcaatgtc gaaatgacgg 953581 caagcacaga aattcgcaaa taagacttgc gtttgccgta ggctaaaatc gctttttgtt 953641 tttcaggact gatgctgaga tcccaatcgt tatcgtcctc tagttcgctg tcaatcagtt 953701 cctgatatac ttcaagcttc tcgagttctt cctcaaatgc agtcatttcc tggtcgctca 953761 tttccccatt tttatattga tcaaaacgct ttttaaattc ttcattcatc attaacacct 953821 ctattataaa gtgctttcag ccgctgtctg gcacgaaata aaacactttt aaaattcgcc 953881 tctgaaatat tcataatatg ggatgcttct ttgtagttta actcttttaa ataatatagc 953941 gttaaggcct cccgataatt atcggggagc tcggacatat aaccagtcag cacttccttt 954001 atctctacct gatgggcagg actttgaaca gcattttgaa agaggcttcc gattaagtca 954061 tcagaaatgg ttacttcttt cttatgcttt ctgacgtaat caatgaaggc gtttcgcgcc 954121 acttgaaaaa gccagggctt tactttgctg tgatcatagg agtgaatgtg tatgtatgcc 954181 cgcataaagg tttcctgcag taagtcttca gcaagatgct tgtcttttgt catggagagc 954241 aggaacctgt aaacatcatt catgtacatt tggtaaattt catcgatcgt cactgccttt 954301 tctcccctct atgttataca cgcataagaa aggtttaaag ttgcacatta catgcaaacg 954361 gcttttttat acctaatcaa acaccattac tatatagtac ccaaaaatgg ccgcaaaaga 954421 tagtgcggag aaaggtttaa cattttttcc agaggggaaa agatagtgaa aaagtgaagg 954481 agtggcacaa tggaatatac cagtatagca gatacaggaa tagaagcctc cagaatcggc 954541 ctcggcacat gggccattgg cggaacgatg tggggaggca ctgacgaaaa aacatcgatt 954601 gaaacaatcc gcgccgctct tgatcagggg attacactga ttgacaccgc accggcttac 954661 ggcttcgggc agtccgagga aattgtcgga aaggcaatca aagagtacgg caaaagagac 954721 caggtgattc tcgcaacgaa aacggctctg gactggaaga acaaccagct gttccgccat 954781 gcgaacagag cgagaattgt agaggaagtt gagaattctt tgaagcggct tcaaacagac 954841 tatattgatc tttatcaggt gcattggccc gatccgcttg tgccaattga agaaacggct 954901 gaagtcatga aggaattata tgatgcggga aaaatccggg cgattggcgt cagcaatttt 954961 tcaattgagc aaatggatac atttcgcgcc gtcgcacctc tccatacgat tcagcctcca 955021 tataatctgt ttgaaagaga gatggaagag agtgtccttc cttatgcgaa agataacaag 955081 ataacaacat tattatacgg cagtttatgc agagggctgt taacaggcaa aatgactgaa 955141 gaatatacat ttgagggcga tgatctgcgt aatcacgatc caaaattcca gaagccccgc 955201 tttaaagagt atctttctgc tgtgaatcaa ttggataagc tggcgaagac acgttatgga 955261 aaatcagtga ttcacttggc tgtcagatgg atcttagatc agccgggagc ggatatcgct 955321 ctttggggag caagaaagcc tgggcagctt gaggccctat ctgagattac aggctggacg 955381 ctgaacagtg aagatcagaa agatatcaat actatattgg aaaatacgat atcagaccct 955441 gtcggaccgg agtttatggc cccgccgacc agagaggaaa tataacaaaa gctgagggcg 955501 aatcctcagc tttttggcgt ttaaacgaga gaaatcttaa aaattagtac caggtaataa 955561 aaaatattgt tataatagat gacagaaaga atcattgatt acgacaaagg aagtgcgata 955621 tgtataagtt ttgtgcaaat gctttaaaag ttattctttc tcttcgcgga ggagtgaagg 955681 tgtataacaa agaaaacctt ccggccgatt caggttttgt catcgcgtgt acacattccg 955741 gctgggttga tgtgattaca ctcggagtcg ggattcttcc ttatcaaata cactacatgg 955801 cgaaaaaaga gctttttcaa aataaatgga tcggttcgtt tctgaagaaa attcatgcct 955861 ttccggtaga tcgggaaaat cccgggccaa gcagtattaa aacgccgatt aagctgctga 955921 aagaaggaga gatcgtcggt atcttcccaa gcggaacaag aacctctgag gatgtgcctt 955981 tgaaaagagg tgcggtgacg attgcgcaaa tggggaaagc gccgcttgtc cccgctgcat 956041 atcagggccc ttcaagcgga aaagaattat tcaaaaaagg aaaaatgaag ctgattatcg 956101 gtgagcctct tcaccaggct gattttgccc acctgccttc aaaggaaaga cttgcagcaa 956161 tgacagaggc tttgaatcag cggattaaag aactagagaa taaacttgat cagctataag 956221 gcgttctgag agattgtcct gaaactgtga aaataagaaa agcaccctat acaaggtgct 956281 tttcttatta tgcttcctgc tggttagctg tctccagaag ttcttcttct tgaagctttt 956341 tcacttcaat atatgcgacg tggtggccgt caatttcatt aatgatgaat tcgcagccct 956401 cttcgatgat ggaatcatct ttttcaacat cgtatttttg agtaaggaac cagccgccga 956461 ttgtatcgac ttcttcgttc tctaaatgga tgcctagcag gtcgtttact tggtcaatta 956521 acacttttcc gtcaagaata taatggcctt cgccgatttt gcggatttcg ctaatttcat 956581 caatatcaaa ttcgtcgcgg atttcaccga caatttcctc aatgatgtcc tcaaccgtca 956641 caagcccggc agtaccgccg tattcatcag acaaaatggc catgtggacc ctctcttttt 956701 gcattttgac aagcaggtct tggatcggcg cagattcaat gacatgaatg atagggttga 956761 cgaattgaga aatggtggaa tcaacagata cctcaccgct gatgcaggcg gtcagcactt 956821 ctttaatgtt aataaccccg ataatgttat ctttatcgcc ctcttccaca gggtagcggg 956881 tatatttttc aatctgaatg atgtccatca tttcagaaat cttgatatca tgcggaaggc 956941 tgacaatttc ggtccgcgga atcataattt ctttcgcgag cctgtcgtca aattcaaaga 957001 ttttattcac atatttaaac tctgattggt tgatttcacc gcttttatag ctttcagaca 957061 aaatgattcg cagctcttct tctgagtgag ccagttcgtt ttctgaaacg gtctccaggc 957121 caaatgcttt ggtcaataac cgtgcggaat tgttcaaaag ccaaatgaat gggaacgcga 957181 tgcggtaaaa ccaaatcagc ggtttcgcaa acagcataga cactgcttcc gccttttgga 957241 tagcgactgt tttaggtgca agttctccga caacaacgtg taagaacgtg ataatggcat 957301 acgcaaaaat aaacgatatg acatgtgaaa gggaacctgg aacgttcatt tggacgaaaa 957361 gcgggtgaag cagcctttcg atcgttgatt cacctaaaac ccctaatccg atggaagtca 957421 atgtaattcc gagctgacac gcagataaat attcatcaag atgcgtggtc acttttttta 957481 cggctattgc tgctttattt ccttccgcga tcagctgatc gatccgtgag cctctgattc 957541 tgataatggc aaactcagat gccacgaaaa atgccgtcag ggcgattaaa acagcaacta 957601 aaatcaaatt cactatgtcc aattagaacc ttcactctag caatgagaat gaaggtaaca 957661 cctcctgtta gataaaatgg ttttaactta acagcagcat aaatgattgg aacacggcga 957721 gcttttcagg cgggagtttg cttttcagct tgtcacgatc ctcgggcttc agccgttcaa 957781 accgatgcaa gattccggag atgttttgat tcatatgatc aatttctaat gccagatttc 957841 caatttcatc atcaagttta gctgaagagg gaaactggtt ctccagtcga tctttaatat 957901 cggacagggc caatcgctgc ttcttgcaat ctacaataaa tataagtcgt ttgagtgcat 957961 tttcgtcgta gtaacggtaa tttgaacagg atctggccgg cgtaagcaga ccgagattcg 958021 tataataatc aactgtccgt ttcgttactc cggcgagtgc cgctagttca ctgatgcgat 958081 aagtctcagc cccatctata tccctcccaa ccatcacgtt atagttatga gaatagttta 958141 atatatgaac ggtgtcttgc acaagtttat tgtttttttt agaccggaat tggaagttgt 958201 ggaattcatc atctgattga agtaacatag gaagatagaa ttttcaaatt tttatatgcg 958261 gaagggacag atgaaattgg ctgggttatc ccgggaagtt gaagaaaact taaataaagg 958321 atcatggatt cgcaagctgt ttgatgaagg tgcaaggctg aagaaggagt tcggggaaga 958381 ccaggtattt gatttttcac tcggcaaccc gattgttgaa ccgcctgaag cttttaagag 958441 agcgttaata gaggaagctg aaaaaggcag ccacggatac atacaaaacc aagggcttct 958501 tgcagcgaga gaaaaagtcg cgcaatttct gggctcgcgt tttgaagctg atttctcagc 958561 ggagcgcatc gtcatgacgg tgggcgcggg aggcgctttg aatgttgcgt taaaaagcat 958621 cgtaaaccct ggggaagagg tcattattct tgcaccttat tttgccgaat ataagttgta 958681 tattgagaac tacgggggaa aagccgtcag ctgcccgttg acaagccggt ttgagatcga 958741 cattgaagcg gtaaggcaat cgatcactcc acagacgaaa gggctgattc tcaatacacc 958801 gcataacccc acaggcactg ttctcagcca gaaaaatata gacgatttag gcgctttatt 958861 aaaagaaata gaagagaaga gcggccagac gatttatgtg ctgtttgatg aaccgtacag 958921 tcaattaatc tatgatgaag agctggcaaa tccgtttcaa tcgtaccatc gtgtgatatt 958981 ggccagctca ttcagtaaag atctcggcat agccggagag cggctcgggt atatcggatt 959041 ggacagccga atgccggatg cggacctttt gatcaacgct tttgtgtatt gtaatcgaac 959101 gcttggattt gtgaatgccc ctgtcatgat gcagcgggct gtggcacgaa tggatgattt 959161 aagagtagac gcgagcgctt ataaagagcg ccgggattta atggtagaca ttttaaaaga 959221 agccggtttt gaatttgaaa tgccaaaggg aggtttcttt gtttttccga aatcgccgat 959281 tgaagatgaa gttgcatttt gcgtgcatgc cgcccaaaaa tacaaattat taattgtgcc 959341 gagcagcggt tttggaatga gcgggcattt ccgattatcc ttcagtgtgc cgatcgagca 959401 gattaaaaac tcacgggaca ttttcatttc tttatataaa gattttgctt aagaaggcaa 959461 agaaaagaaa acagttttca aggctgtttt ctttttatat ccgcaaaatc cttcctcttc 959521 caatccagac aggcgcagaa ttgacaagca ggcatgcagt taaggctttc ttcatgataa 959581 aagtctaaaa attaaaaatc atttttggaa tgagttgtgt tacaataaaa tatacaattt 959641 ataatcaaac tttgactttt ggaggtggta tgatggggcc ctctgcttag gcaacaatac 959701 accgcgtacc tcaatgttaa ggaaaaatga ttatatcagg aggtgactcc ttatcctttg 959761 ttgagaggat agggttaaat ggacgatatt gacagtctga ttttaattgg cgtgctcatt 959821 gctttaaccg cgtttttcgt tgcaagcgag tttgcgattg ttagagtgag gagatccaga 959881 atagatcagc ttatcacaga aggaaacaaa cgggcgatac tcgcaaggcg tgtcattaca 959941 gatttggatg aatatttatc cgcatcccag ctaggcatta cattgacatc aatcgggctt 960001 ggcgtactgg gtgagccggc ctttgaacgg ctgctgcatc cactgtttga accgctcggc 960061 ttgccggact cggtttcaca tgcagtctct tttgcagtcg cgtacggctt gatcacgttc 960121 ctgcacgttg ttgtaggtga actggccccg aaaacggtcg cgattcaaaa ggcagaacag 960181 ctgactttac tgatagcggg ccctttgcgt ttattctatt tgctcctgtt tccgtttatt 960241 tggatcctca atggatcggc gcggctttta tgcgggatgt tcggtttgaa gcctgcgtca 960301 gaacatgatg gttcccattc tgaggaagaa ctcaggatgc tgttatctga gagtttaaaa 960361 aacggagaga ttaatccgtc tgaatataaa tatgtgaata agatttttga atttgataat 960421 cggatcgcca aagaaattat gataccgcgg aaggaaatgg ctgctgtgtc aactgagatg 960481 acgatggccg agatgcttga agtcatgctg aaggaaaaat acacgcgctg gccagtcaca 960541 gatggagaca aagacagtgt gctcggtttg gtcaatacga agcatttgtt ttctgatttg 960601 ctgtttatga cagaagaaga acgaatgaag atgacgatcc atccgtatgt gaggccggtc 960661 atcgaagtga ttgaaacgat cccggttcat gacttgctga ttaaaatgca gcgcgagcgc 960721 attcatatgg ctatattgtc ggatgaatac ggaggaacct cgggacttgt gacgacagag 960781 gatattcttg aggaaattgt cggagagatc cgagatgaat ttgatgaaga tgaacagccg 960841 ctgatccaaa agcttggcga cggccattat gtgatggatg gaaaggttcg gatcgatcag 960901 gtgaacagcc ttcttggcgc atcgattcaa gaagacgtcg atacgatcgg cgggctgata 960961 ttaaaagaaa acatcgatat tgaggctggt gaatccattc gcatcggttc atatacgata 961021 aaggtgctga agatggacgg ccgattaatc aagcaaatcg atataaaaga agaagccggc 961081 aacacaaccg ggattacggc gcaccacaag ctgccgctgc ccgagcctgt gatgctgaac 961141 agtgcaacct tgagcgagaa ataagctcaa ggttttttta tattgtgatt gtccagccgc 961201 accaaaatgc aaaaagcgac ccgcaaagtg tcaggacgat gtacaagatg ctttctttta 961261 cacgtttggc cataaggagt tgaatagttt caacgctgaa tgtggaaaag gtcgtaaagg 961321 cgccaaaaaa ccccgtgcca atgataagcg agaccgaagc atttgcaacg tgaagtcctg 961381 taaatattcc gagcccgaga gctccgagaa tattgactgt cagtatgcca atgggcaggc 961441 tgagaccttt ggttttggcg gttatgacat tgccaagcca gaagcgaagc attgcgccaa 961501 gtccgccccc tatgaaaata cccgctagtg tcatttttcc tgcagcccct ttctttgctg 961561 aatgcctgct atgcgccgtc ccacaaaaac accaatcagt gcaaatatga tccctgatat 961621 caatgaggct gccacatata aaagagccaa tgagggttgt ccttgcaaaa gcatcactgt 961681 ttccttagaa aacgtggaca ttgttgtgaa gcctccgcaa aagccggtgc ctaaaaaagc 961741 cgacagcaga ggccgttttg ccccgatcat aaaaaatccg gtcaaaatgc ctaatagaag 961801 gctgcctgcc gcattttcca gccaggttgc cgccgggaac tgaccggtgt gtatccataa 961861 gtttaatccg tatcggaggc aggcgccaag cgcgcctccg ataaaaaccg cgctatatat 961921 tttcatgttt gccatccttt atgatgaaat ccgggtaatc tgtaacgatg ccgtccacgc 961981 ccatggcttg taattttgcc gctgtctttt gattgttgac agtccatgca aatatgttta 962041 agccattttt attgatggag ccgatcatca gacggttaag ccgtgtgtgt tttatattga 962101 catagtttgc aaaagagcgg aaggccttca tctgatttct ggacagcatg ccaaagttgg 962161 gccttgtaat gaccgctgtc ggaatcgaag gataaagctc gcggaacctt tggacggagc 962221 ggaactgaaa ggattgaaca atattattga tagaaaaaga aaattgccct aatagctgtc 962281 ccacctcttc ttcaattccg acttgagacg gatggccttt tagttcaatt aaaaggccga 962341 tttttttgtg gtagcgcttg agcaccgctt ccagggttgg aatacgctct ccttgaaaag 962401 cgggaccgta ccagcttcct gcatcgagtt tttgcaattc ctccaaggta aaatccttaa 962461 caaagcccga tccgtttgtt gttcggtcaa ccctgtcatc gtgtatcaca acaatctgcc 962521 tgtcttttgt aagctggaca tccagttcga tcatatctgc attcattttc accgcaaggt 962581 caaatgcggc aatcgtattt tccggagcgt agccggatgc tccgcgatgg gcaatgatgt 962641 acaagctaag tcagctcctc gtatgggcat ttctgttatt gtatcaaatc catatatgca 962701 ccgcgataca aactggtgaa ttttttctgc catatcggaa tggtccgggc tgaggaatgc 962761 gtataactaa aaaaagacac tcagcgtatc agaacacatt tcgtcagaaa attaggtctt 962821 tcgacatgtt cacaacaaaa tatgatcctt tataatagca aaaaaggagg cgagatcatg 962881 ggaaaaggga gaatcagagt ggaggaaaga attaaagccg aaacggatgc tgaaatgcaa 962941 aaagcaactc tccttgatca gacacaaacg aaaaaaggta agtgactgtc cctattgaat 963001 ctggctgata gatgaattga gaaatgaccc cggcgtttcg ccggggtttt gtgctgcata 963061 agacatttaa atgaacatcc ttacgaatat tttagtataa taaacaattg attgggatag 963121 aggggagaca gtcatgccgg attatctgca gcagtatttt acgcttgata acatcataca 963181 aatcggcatc agcttggcga ttttgctggt gtttcttata cttagaaaat tattcacaag 963241 atattttttt aacctgcttt ttaatttgac aaaccggccg aaaacagaaa tttttaaaca 963301 ggtggttctg gcgtttgata agccggccag atggtttttt gttgcccttg ggctgttttt 963361 agcgatccgg tattcaccgt ttttagatga gcaaatgccg gtcatcagca aaatataccg 963421 ctcactgatt gtggcgctct tgtgttgggg tctttgtaat ttgaccgcaa catcgtcgtt 963481 tatcttccat aaggtgaacc agcgcttcga gcttgacatg gatgacattc tggccccgtt 963541 tttatccaaa ttgctccgtt ttgtgatcat tgcgctcagt gtcagtgtga tcgctcagga 963601 attcaattat gatgtcaacg gatttgtagc gggccttggt cttggcggac tggcttttgc 963661 gcttgccgcg aaggatacca tcagcaactt cttcggcggt attatcatta ttactgaaaa 963721 gccgtttaca attggtgact gggtggagac gtcgacagta acaggatcag tcgaggatat 963781 tacctttagg agcacgagat tcagaacagc acagggggcg cttgtaacgg tgccgaactc 963841 tacgctgtcg atggaagcga tcacgaactg gacaagaatg accaaacgcc agattacgtt 963901 ttccatccat gtgtcctacg ctacgccgat tgagaacctt gaacgctcca ttcattctct 963961 cagaacaatg ctcttagagc atgagggcgt tgataatgaa ataatcatgg tcaactttga 964021 tacgtttgcc gacagctact acaatttatt ttttaacttc tatacaaaaa cgacggtttg 964081 ggctgaaaac cttaatatta gagaggatat caactataaa attattgaga ttttaggtgc 964141 agaaggcgtt cagtttgcat atcccggcca aatggttgtt gtcaagcaaa agcacgaaag 964201 cgaccaattc caggtgaatc taaataaaga ggaaaaggaa cgggcttaaa agagagactt 964261 cgtctgacag aggcggagtc tttttcatgg taaaataaga gaaaaaggcg gtgttgagtt 964321 ggaaacattc aaaagtattc tacatgaagc acagagaatt gttgtgctga ccggagcggg 964381 aatgagcaca gaatcaggga tccccgactt tcgttcagca gggggcattt ggacggagga 964441 tgcctcaaga atggaagcga tgagccttga ttatttttta agttatccgc gtctgttttg 964501 gcccaaattc aaagaattgt tccagatgaa aatgagcggc agctttgaac cgaatgaagg 964561 ccatttgctt ttagctgagc tggagaagca agggaagcag gtcgatattt tcacgcaaaa 964621 cattgacggt cttcataaaa aagcggggag caggcatgtg tacgaactgc atggttctat 964681 ccagacagca gcttgtccgg catgcggcgc ccgatatgat cttccccatt tgctggagcg 964741 ggaggtgccg gagtgcacgg cggccggaaa caatggggac atttgcggaa cggtattaaa 964801 aaccgatgtt gttctctttg gcgatgccgt catgcacttt gacacccttt atgaaaagct 964861 ggatcaagca gatcttttat tggttatcgg cacgtctctc gaagtggctc cggctagatt 964921 tgtgcctgag gatgcaagcc tgattcccgg catgaagaaa gtcatcataa accttgaacc 964981 aacgtattgc gacagcttgt ttgacatggt catccatcaa aaaatcggcg agtttgcccg 965041 aagtttgggc atgaaaaagt gagccgcttt atgcgcctca cttttttatt catgaacagg 965101 aaccattgtg tcctctaaca ctccgaagga atagcctttt tcttttaatt tattgattag 965161 taccggcagc gcatttacag tagcaggaag atcatgcatg agaattacat ttgggcggct 965221 tgaagagctg tgttccatat tctcaagctg ctgtaatacg gcggtcacat actgtgaatt 965281 ccggtatttc cagtccatgc tgtcgatcgt ccaatcccag tacacaaacc catctttctc 965341 cagattgcga atttgtgagg cggttagtga cggcttgctt ccgtatggcg ttctgacaag 965401 atcggtttta tatcctgtaa tgtcctgcag cgtgtcacgc gcctcctgca tttcttttag 965461 cggagatgtc ggtgtttgat agaacaatct gttattgtgg gtaacgccat gtaaaccgag 965521 tgcgtggcct tccttttctg ctcttttcac agcctgcttg aattcgttca tccgcggtga 965581 cagcataaaa aacgtcgctt ttacatcagc gcttttcagt acgtcgagca agcgggttgt 965641 aacggctgaa gggccgtcgt cgaaggttaa gtaaaccgtt ttatctccca tgttctgctt 965701 tgtctgcaga tgttttatca ggagatcggg ggagtcgttt ttcagcttaa ggctttcctt 965761 ctcatctcga agctggccgt ttgttgtgac agtgacttcc tttgctttcg ttgaactgtt 965821 ggaataaccc aaaatcacca taagcaaaag cagcacacat aaaactgcta aacttgcaaa 965881 tttaaaagca agcgaaactg cagaaggaga agcctctcct ctcgtttgtc gcataacaat 965941 ctctccattg gcataaaatc tctacataat gctgtacagc aggcagctta tgaagatgcc 966001 ttatgtttac aacctatgta ttaccagtca agtatacagg aataaaactg gaaagcacat 966061 agaaaatttg tcgaaatgtc agattttaag gaaaaaataa actcctttcc gctatagatc 966121 tcttgatctt tctgtttttc agcttgtcca atatggtaga attagtgata atgacagctt 966181 gaatgacatc agggacatct cgaaaaggga gggcttttat gaaggtttta gtcaatggcc 966241 ggctgattgg gcgcagtgaa gcatcaatcg atttggaaga tcgcggttat cagtttggtg 966301 acggcatcta tgaagtgatc agggtgtaca aaggagtatt gttcggctta cgtgagcatg 966361 cagagcgttt tttcagaagt gctgctgaaa tcggaatttc actgccattc agtatagaag 966421 atctcgagtg ggacctgcaa aagcttgtac aggaaaatgc ggtcagtgag ggagcggtat 966481 acattcagac aacaagaggt gtggccccgc gaaaacacca gtatgaagcc ggcctcgagc 966541 cgcagactac tgcctatacg tttacggtga aaaaaccgga gcaagagcag gcatacggag 966601 tggcggccat tacagatgag gatcttcgct ggttaagatg tgatatcaaa agtctgaatt 966661 tactgtataa tgtcatgacg aagcaaaggg cctatgaagc cggagcattt gaagccattt 966721 tacttaggga cggcgttgtt acggagggta catcctctaa cgtttatgcc gttatcaacg 966781 gcacagtgcg aacacatccg gctaatcggc tcattctcaa tggaattaca cggatgaata 966841 ttttaggact gattgagaag aatgggatca aactggatga gactcctgtc agtgaagaag 966901 agttgaaaca ggcggaagag atctttattt cgtcaacgac ggcagaaatt attccggtcg 966961 tgacgctcga tggacaatcg atcggaagcg ggaaacccgg accggtgacc aaacagcttc 967021 aggctgcttt tcaagaaagc attcaacagg ctgctagcat ttcataaatg aacgaagaaa 967081 agagcccgct ttttacagcg gggctctttt tattttttaa caaatccaat caaaatggag 967141 atcattggcg atatatagag gaagaacgta aatgggatgt agtctatgac tggaacacca 967201 agtgcgctcg ccataaatgc gccgctgacg ccccaaggaa tcaatgggtt aattaatgtt 967261 ccgccgtcct ctaatgatct tgtcagaaat tttcgctgga tgtttcgttt gtcatataaa 967321 gatttaaatg attgtcccgg tattaatatc gataaatact gttcgcccgt tgccaagttg 967381 acgccgatgc ttgagcagac agttgctgca acaagacggc cttttgagcg gatgcctttc 967441 atgacgcctt ccaatagtgc agaaatcaat ccgattttct ccatcaatcc gccgagtgca 967501 aaagcaatca taatgagaga gacagagccc atcatggatt gcagtccgcc tctgttaata 967561 attttagcgg ctgcctcatt gtcagtttcg aaagttgtgc cattttgtaa agctgtcata 967621 aacgcctgca ggctgctgta gggtacaaaa atagcagtca aaattcccga ggaaataatt 967681 ccggcagtca gaacggggat tactgatacc cgtttcattg ccagcaaaac gactaagagc 967741 ggagaaagaa gggcccacgg tgtcacgttt gcagcatctt ttattccggt tatgacctgc 967801 tgaatattat cggttgaagc agcgtccgct gacactgatg aaccgagaaa gtaaaacaga 967861 acgacagtga tgagcaaagc tggaatggtt gtgcccatca tatggcgaat gtgttcaaag 967921 attggtattt cgcctattcc ggctgcaaag ttggttgtgt ccgacatcgg cgacatttta 967981 tccccaaaac aagcgccgca tatgactgcg cctgctgtcc attcaagcgg aacgccagcc 968041 gcgctcgcca cgccgatcag cgctactccg attgtgctta cagttgtcag acttgagcca 968101 acaagtgtgc tgatgatcat acatgaaaac aaagcagtca acagaaggtg gcttggttca 968161 ataaaggata gggcataaac tgtcatagtc ggtattgcgc cgctgtacat ccaggcgccg 968221 attaagatgc cgatcagcgc tagaacaata atcggctgta cgccgttttt gatcccgtct 968281 acaatccctt tttcaatgct cttccaggga aatccaaacc ataaagctgc tgctgaaagc 968341 atgacaacac ttaaaaacag cgggatatga ggttctacat gaagcaagaa taagcaagaa 968401 ataataatgc acaacatgaa tataaataaa ccgacggcta acggaaacgt cagctttttt 968461 tgagaatcca aaataacacc ccatatttat ctttaatgct tttgtgcttt tgggcacgaa 968521 agcattataa cagaaaaaaa cgaaaatcta tgttttttca caattatgaa tataaaagaa 968581 gtgagcacag ggcgtgctca ctttacaatc aggacgggta tatccgattt cgctgaaagc 968641 ttttcactta cacttccgaa tattagcttt ttcagcctgt tttggtctct gcttccggtt 968701 acgatcatat cggcagaaat gcggtttgca tgctcgataa ttgattcagc cggatcgcct 968761 tctaatatat cgatatctcc atctgcctgc tgttcattca gcatcattct ggcttcggcg 968821 atgacttctt ccgtacggtc ttcatagatc attggctcag gtgatgttac atccgatatc 968881 agcggatcag gaacacttgt catgcctccg ctgatatagc ttgcctcagc tgcgggtctg 968941 ggcgggtcga tgacggtctg attgtctttc atatcatgtg aatgggcgac ggtaatagcg 969001 gcatttacgg ttttagcaag atcaatggct gtcagaagcg ctttcttact attttcactt 969061 ccgtcaaacg caacaatgat acggtcagca tggaacatcc ttctcaccct ttcaaagcgt 969121 cttacaacac tactacccga atttgagcac aattaacctt ttcctattca agtaatgatt 969181 gacaataaaa ggttttgttt atatgatgat aaaaagatga aatcagaatg gaaggagggt 969241 ttgctatgcc aaggaatttg cgtgtttatc aaacagtttc atattggcgc ggcaaacctt 969301 ttgttctgtt ttcgtgaacg gttttttagg tcggaccgcg cgctgaaaag cgctgtgcgt 969361 aacatatcgg ttaaaaaagg catggagctg acgcttcatg ccttttttat atacaaaatc 969421 taaggaaaga caggtgtatg ggatgtgaag acaaatacag aggcgagggc agttcgtgcc 969481 aaactggatg aaaaaagctg caaggaaaaa atagaaggcg gctgatgagg agatggggat 969541 agatgttttc agttttgaaa aagcttggct ggttttttaa ggcgtactgg ctgcgctata 969601 cgattgcgat tgtcctttta ttagcagtca atgtcattga aatgtttccg cctaagctct 969661 tggggaacgc catagatgat atgaaagcag gggcatttac tgcggaaggg ctgctgtttt 969721 atatcggtat cttttttgtg ctgacggcgg ccgtgtatat catgtcttat ttttggatgc 969781 atcagctgtt tggcggagcg aatctgatgg agaaaattct tcgtacgaag ctgatggggc 969841 atttgctgac tatgtcgccg ccgttttatg aaaaaaaccg aacaggcgat ttaatggcac 969901 gagggacaaa tgatcttcag gccgtcagtt taaccacagg gtttggcatc ttgacgttag 969961 ttgattctac gatgtttatg atgacgatct ttttgacaat ggggtttttg atcagctgga 970021 agctgacctt tgccgccatt atcccgcttc cagtcatggc gattgcaatc agtctatatg 970081 gaagtaaaat tcatgagcgg tttactgagg cccaaaacgc gttcggggcg ctgaatgaca 970141 gagtgctgga atctgtttca ggcgtgcggg tgattcgcgc gtatgttcag gaaacaaacg 970201 atgttcgccg gtttaatgaa atgaccgctg atgtttatca gaaaaatatg aaagtggctt 970261 ttattgattc actgtttgag ccgacggtaa aactgcttgt cggcgcaagc tatctgattg 970321 ggctcggcta cggagcgttt cttgtattcc ggaacgagct gacgcttgga gagttagtgt 970381 cctttaacgt ttatctcggc atgatgattt ggccgatgtt tgcaatcggt gaactcatta 970441 atgtgatgca gcgcggcaat gcgtcattag atcgggtaaa tgaaactctt tcttatgaaa 970501 cggatgtgac agatccaaaa cagcccgctg atcttaaaga gcctggagat atcgttttca 970561 gtcatgtcag ctttacatat ccaagctcaa caagtgacaa tcttcaggat atttcattta 970621 cggtgcgaaa agggcagact gtcgggattg caggtaaaac cgggagcgga aaaacgacaa 970681 ttattaagca gcttttgcgc cagtatcctc caggtgaagg gagcattaca ttttcaggtg 970741 taccgattca gcaaatccct cttgaccgtc tccgcggatg gatcggatat gtgcctcagg 970801 atcatttact gttttcacgg actgtaaaag aaaatatttt atacggaaaa caggatgcaa 970861 ctgataaaga ggttcagcaa gccattgccg aagcacattt tgaaaaagat ttgcacatgc 970921 ttccgtccgg tctggagaca atggtcggtg aaaaaggcgt ggcactgtca ggcgggcaga 970981 aacaaagaat ttcgatcgcg agagcactca tggcgaatcc ggaaatcttg attctggatg 971041 attcactttc cgctgtagat gccaaaacag aggctgcaat tatcaagaac atcagagaaa 971101 accgcaaagg aaaaacgaca tttattttga cacaccgatt atccgcggta gagcacgctg 971161 acctgatcct tgtgatggac ggcggcgtca ttgctgagag aggcacgcat caagaactgc 971221 tggccaataa tgggtggtac cgggaacaat atgaaagaca gcagctgttc actgcggaag 971281 aagggggagc aggggcatga aaataggaaa aacgttatgg agatacgcac ttctttatcg 971341 aaaattgctg atcacagccg tccttttgct aactgttgcc gtcggtgcag aactgactgg 971401 gccctttatt ggcaaaaaaa tgatagacga ccatatcctc ggcattgaga aaacatggta 971461 tgaagctgcg gaaaaagata aaaatgccgt tcagtttcac ggcgtctcat atgtcagaga 971521 ggaccgattg caggagcctg tttcaaaagc aaaagaagcg catatttatc aagtgggaat 971581 ggcgttctat tttgttgatc aggctgtcag cttcgacggg aatagaacgg tttctgacgg 971641 gaagctgacg atcacaaacg gagacaagag ccgggcatat gctgccgaaa agctgactaa 971701 gcaggaactt ttccagttct atcagccgga aataaaggga atggtgttac tgatctgcct 971761 gtatgggggc ttgcttgtgt tttcggtatt ctttcaatac ggacagcatt atctgctgca 971821 gatgagcgcc aatcggatta ttcaaaagat gaggcaggac gtgttttcgc acatacagaa 971881 aatgccgatt cgctattttg acaaccttcc ggccggaaaa gtcgttgcgc ggattaccaa 971941 tgatacggag gctattaggg atttatatgt cacagtgctt tcaacatttg tgacaagcgg 972001 aatctatatg ttcgggatat tcacggcttt gtttctgctt gatgtgaagc ttgcgtttgt 972061 atgtctggca attgtgccga ttatctggct gtggtcggtc atataccgga gatatgcgtc 972121 atattacaac caaaaaatcc gctcgatcaa cagtgacatt aacgcaaaaa tgaatgagtc 972181 aattcaaggc atgaccatta ttcaggcttt ccgccatcaa aaggaaacaa tgagagaatt 972241 tgaggaatta aatgaatcac atttttattt ccaaaacagg atgctgaatt taaactcctt 972301 aatgtcccat aatctggtca atgtcatccg caatcttgcg ttcgtctgtc tgatctggca 972361 ttttggcggt gcgagcctga atgcggcggg gattgtttct atcggtgtgc tgtacgcgtt 972421 tgtcgattat ttgaaccggt tatttcagcc gatcacaggc atcgtcaatc agttttcaaa 972481 gctggagctt gcaagggtct ccgccgggcg tgtttttgaa ctgcttgaag aaaagaatac 972541 ggaagaagcg ggtgaaccgg cgaaggagcg cgcgctgggg cgggttgaat ttcgtgatgt 972601 gtcatttgcg tatcaagaag gtgaagaggt attaaagcat atttccttta ctgcgcaaaa 972661 aggcgaaacc gtagcgctcg tcggccatac cggatcagga aaaagctcga ttttgaatct 972721 tctgtttcgt ttttatgatg cgcaaaaagg tgatgtctta attgatggaa aaagcattta 972781 caacatgtca agacaggaac tcagatccca tatgggtatt gtgcttcagg acccgtactt 972841 attctcgggc acaatcggat ctaacgtaag tctggatgac gaaagaatga ctgaagaaga 972901 aataaaaaat gcactgcggc aagtcggtgc tgagcctctt cttaagaagc ttccgaaggg 972961 cattaatgag cccgtgattg aaaaaggcag cacgctatcc tctggagagc ggcagttaat 973021 ttctttcgct agagctttgg cgtttgatcc cgcgatcttg attttagatg aggcaacggc 973081 gcatattgat acagagacag aggccgtgat ccagaaggcg cttgatgtcg tcaaacaagg 973141 acgcaccacc ttcgtcatcg ctcaccggct ttcaacaatc agaaatgctg atcagatttt 973201 ggttcttgat aaaggagaaa ttgttgagag agggaaccac gaggaactga tggcattaga 973261 aggccaatat tatcaaatgt atgaactgca aaagggacag aaacattcca ttgcataacg 973321 ctcaaaaacc caaaacaatc gtgttttggg tttttggttt atgtagtcaa taagccagtc 973381 cgacacggtt tccgacatac tcacctgtaa cgagctcacg atataaaaag tccgcagtat 973441 cgccgaccga aatgcttgtg ccgccctcag gcaaaacgtt acgctccgta cgataaacgc 973501 cggttgctgt tccgtccggg aggtaagtgg ggcagatgat tgtccagtct aatgatgatt 973561 ctttaagcat ttcgtatact tttgcatgct ccttggctgc gcgggtctgc tttcgtttcg 973621 attcatttgt ttcaaaccgg tattttcccg gttcatatcg ggaatctagg atccctgcgg 973681 tgccgatcgt aataagccgt ttgatatgct gttcctccat aacggagaga atgtgtgcca 973741 tagcagttga caaggtatca tcaccatctg tgcctagaca gctgatcacg atttcagcat 973801 tctccattat ttttttcaca tcttctaagc ggcgggcgtt ccccatgaca gttctgtctt 973861 ttgaaagggg aagatcagca tgttgagatc tgatcagagc gaaaatatca aatctttcat 973921 ctgctgcagc ttgtgttaaa aaggcttgtc cgacgcggcc gctggctcct aataaagcga 973981 ttttcattaa aaaacctcct cgcctttcat tataaaagga tgttctcagt ttgaacagcg 974041 cgggaaagaa tacctgtaca aataaacaga acgatgggaa acatattcat gaatcatgga 974101 tacacttacg aattgaacca gctcccaatt cacaatggtg atgaatgaca ccccgattcc 974161 ctcccttttt ttctaggata tgtggagcag gaaaaaaggg tgacaaaata aagagagcgc 974221 ggaaaccgcg ccctctatag ccatatattg aattgttatt gaactctgcc gcccatttgc 974281 tgctgagcga aagatactaa acgttttgtg atttctcctc cgacagaacc gttagcgcga 974341 gaagttgtgt ccgctccaag gttaacgccg aattcagaag cgatttcaag tttcatttga 974401 tcgatagcct gagctgcgcc aggaactagt aagtcatttg aagagttttg gttagccatg 974461 tgtaaaatct cctttttatt tagtatggtt gggttaactg gagttgcacc aatctgtgaa 974521 cccttctcgg gtgtcactgc cgcctcggcg taacccaatg ctttgccggc ttgttactac 974581 gtattatgtt aaaatggccg gaaaatcatg cggagaattg tgtggtaaat cttgagaaat 974641 aaaaaaagct tagccgttta ggctaagcta gtcataaata tgaaaaagca tcagttcatg 974701 tatctcgttt gtaagagcag gctcgtcagc gcgggcggga aacaagtctc cccattcaat 974761 ctcaccgctc ttatgataga tgccttcata atgggtccct ttataataaa atgaaatttt 974821 ccatccgggc agcttttctt ttgggaacaa aggtttccag ctgaaatgag aaatcattac 974881 ggccacgctc cttacatttg gtatcaattg acctaaataa aaacggctta tgttcattgt 974941 atcattgttt cagaacatca ttgaagaggc ctaaatatgc agtttgtccc agctttggat 975001 aaagataagc ccgctttatt aaaaaagcgg acaggttacg aaggccacaa tgcttccgga 975061 gatgtgattg ccttctcaga taaatatgac gcgtattcaa aacttcttcg ttttgtaaga 975121 gaatcaacat gatgcaaatt tggatgagaa aaaatgcttc ggcccgggcg cgaattcgct 975181 tcaaacatcc atactttacc gttctgatca atgccaaaat cgaaaccaat ctccccgata 975241 aatccctcga tatgatcatg aaggacatgg cttgcagtca gtgccgctgc agaaagcttt 975301 ttaatgacct caactctttc agcgggatca tcgtatactt ccgcaagtgt ctttacagtg 975361 ccgccgttag aaagatgtgt tgtaatgctg ttctttccgg aaatttttac ggcgattgct 975421 gtcactgtcc attttccttt tctgttttta ttggtatgga cacggaaatc cgctggtttg 975481 ccttgaaatt cgatgagatc aacaccttgc tgaatgagaa agtcggacgg gttgtgatgt 975541 ttttgaaatt ctgcaaggaa tgaggcggca tcggaataat caattgatgt aaaagttttg 975601 gcgtcattcg tatgctttac cgtcaggccg ccatctgttc ttgtcagctg ataaatgccg 975661 gtgccgagtg ctccatttgc cggtttgata tagacttttt tgtatgcgcc acagagctca 975721 tctatcagct ccacagacgg tgtcagctcg gatctaggca aaaagggtgc cgttcttgga 975781 tctttttcga gcaattgatg aacgttccat ttattgaaaa acgttttatt aaaccatggg 975841 atctgatatt catcgatcag cctctttttt gtatgttgca agagaagtga atcttcaatt 975901 tttcggttcg gcaaacggtc ataaacgacg ttcggcaatg gaacgatttt tttctcccag 975961 ccgttttccc tgtaaaggag gccttcaatc gtgccttcct cccaattgat ttggtgcgcg 976021 ccaaaaacga agcagtagcc cccggcttgc tcgtgtaacg tgacaagttt agaaaaaaag 976081 agggaacgat ccttaaatgg gcgttcaaga gatacagtaa accctgccgt aaagatgccg 976141 actaacggcc cgatatgcac tgtatgatca tgaatcagta tatctgccct gcttcggtgg 976201 ggaagcaaaa gctcatgaaa cagattttca gagagaagca cggtttgttc cagatgccgt 976261 ctgtaagcaa cgtggcatct gacaaccttc gttccgaatg cggcatgcaa aagtccgtct 976321 tgcttcagcg aagagggcag aaacagggtg ttttcactgg ttttgtctat gccgatcaaa 976381 aaccgtttag gattcacgcg gaagaactcc tttctggctt tgctcagaaa acagatattg 976441 gcagcgtttt aggggacaag tgtacagctg ttctttttgc tcgggagaga cacgcaggat 976501 tgacttcctg cctggtttgg aattgatatc taaaatccaa attctcccgt cctttgcaag 976561 acatatatca agaccgagtt caaacaacgg cccatagcgc tcgtcaagat aatacggaac 976621 cgattgggta attgaaaaca catcatctag taaaaccact tgctgttttt tcggtatatc 976681 ttcaaaccag gagtcaaatg tcagcgcatc agatccgcct gacaaattgg ccagcagccc 976741 gtgtttgtat ccgcgtctta ctgcctttcc gactgtattc cattcacctg cttcgttttt 976801 ttccataaac agacgaatat cacaagggta ttgttcctta tcttgaatgt ttaagtaagg 976861 ctgaagcaaa tattgatgct gaagcacttt tttgcaccat gttttaaaag aagtctggtt 976921 ggaaaacgtt tttgtctgct tatcctttcc gatgtgataa gtagcagtga tgtttttctt 976981 gcccagcttc aaaagaatca cgcctctgcc tcccgcgccg aatgccggtt taaggatgca 977041 ggctttttct ttggataaaa aggagtgaat ttgttcgtag cggctcacct ttatcgtttc 977101 gggaatatag ggattgatta cagagtgctg ctgcaaatcg tgaaggacgg tccacttatc 977161 gggaagaccc cgcccgataa attccgtttt cggatatttt ttgagccact caacgattgg 977221 ttttgctttt tgggaatgtg aatccttgcc gtaaaaacag cgatcataaa tataatctgg 977281 aatcgccatt tcagtttcgt tccatgtgct gctggccgaa tgatagaccg atgctttgac 977341 acgcaaagtg tcaggtgaaa tatcaaatgg tgtaaaccgg atgaaacgta tgccgaattc 977401 gggtgctctt ttggccagtt ctgcggaata atccgcttca tgctggcggg ataaggacat 977461 aaaaccgagt gttatcatgg tgagactccc ccttttattc aaaagctgcc ggcgggtgtc 977521 cgcagcttta cactaaatac atgtaagacg aacgcagctg acggtattct actttacaga 977581 atacgattct ccaccttgcc ctattccaaa agaacaagct gattttctaa gaacaggaat 977641 ttgtctcctc gtttgctaag tgattgcatg agcctctata atacgtatag gtacataatc 977701 tatatgaaaa aagctgaagc acagatggag gaagatgaat aggaatgggt attgcaggaa 977761 cctttatttt tatgatcgtg atcggcgctg ccattggagc ggtgaccaat catttagcaa 977821 ttcaaatgct gtttaggccg tataaagcgt actatttgtt tgggaaacga gttcctttta 977881 cgcccgggct gattccaaga cggcgagatg aacttgcaaa acaaatggga ctgatggtag 977941 tcaatcatct cttaacccct gaaggcatta aaaagcggct cgtctctgat gcagccaaaa 978001 cgcaggctct tcgagtgggg gaacagctga ttcaaaagct gtcactttct gaagtgacag 978061 taaaagaagc gcttgaaaaa gccgggatga agcgccccga aaaagctgct gatgcatgga 978121 tcagcagctg gaccgatgat aagctgcatg agcttttccg ccaatacggg gaccaatcgt 978181 taaaagagct ggtgcctata gaggtgcagg aaaagcttga ggaaaaaatt ccgatgattt 978241 caggatatat attgtcacgg agtgtccgtt attttgaaag tgatgaagga aaaatccgtc 978301 ttggcaatat gattgatgac tttttaaaag agcgcggcat gcttggaagc atggtgcaat 978361 tgtttcttgg caattcaagc cttgcggatc gcgtgctgcc ggagctgctg aaattcttgc 978421 gcaatgagga aacaaataaa ttgctttctg atctcttaaa aaacgaatgg ggcaagctga 978481 gggagtatac gtttaatgaa gcagatgaaa aatggaatgc aaaggcgctc attttcagtt 978541 tgaaacgaag agtgctgcaa gcattttcga ctgccccttt cttcaacaat acgattggca 978601 cgcttaccgt ccgctatgaa tctgagctga cccagcaaat gctgccggca ctattagaca 978661 aattgcttga aggtatttcg tccaaccttg aaagtgtctt aaaacggttg cgtcttgagg 978721 aaatcgtcaa ggagcaggtg gatcagttcc cggtggagcg tcttgaagaa atggtgctgt 978781 ccatttcaaa aaaagaattt aaaatgatta cctatttggg gggccttctc ggcggaatta 978841 taggcgcgat tcaagcattg tttgtcatcc ttttttaaga agaaatggtt tttgattaat 978901 gaaaggagct ccatagtctg ttatagtgga gtggtatgtc aaacggcaat gatgaaagga 978961 gctatttaca atggctgtta atttttatga tgtagcgtat gatctggaaa atgcattacg 979021 cgggagcgaa gaattcaccc gtttaaaaaa cctttacgac gaagttaacg cagatgaatc 979081 agcgaagcgc atgttcgaaa acttccgtga tgtacagctt agactccagc aaaaacaaat 979141 ggcaggagaa gagattacac aagaagaagt gacgcaggct caaaaaacag ttgcgcttgt 979201 acagcagcac gaaaaaattt ctcagctgat ggaagcggag cagcgcatga gcatgctgat 979261 tggtgaattg aacaaaatca ttatgaagcc tttagaagag ctttacggca gtgttgaagg 979321 ctaataagca aaatcccttc ttggataaga agggattttt tattcactca gcaaacttgg 979381 aaatccaatg aatcttttac ctctccattg atgatgactg ataatgtatg aattcctttg 979441 taatgctttc tggtggttaa atccttaaag gattggattc ttgtgtatga cttcgtttcg 979501 ttttttcgta tatttgtttc tgttatttta aatactttct gatgacgctg gcctcttgct 979561 tttacaaaat caattgcgta ctcaattctt actttttgat ccctgtctga atgaatatag 979621 aaagaaaatt caaggctttc gccaataact atacgtttgg gctggcatgt taaatcatgt 979681 agttgtatcg aatcagcatt ttcataacca aaaagcgcta aggcctgttt atcacccttt 979741 tttaataagg tccgataggc gtgtttgata atccagtctg tatggggatg tgttccgtac 979801 cattgatctg cgacttttct cagtaaatga ggatgcgttt ttgatatatc attaaggttg 979861 ttggccacgc tttttcttac atataaagac tcgtcctgca tcagcttctc aaggatcggc 979921 aatacggggg aagggtccga tttcaaagcc ggtatcgatt ttccccatgg caggcggggc 979981 ctgctgcctt cgctcgcaag tcttctcacg tgttcatttt tatgctcaga ccatgcaagc 980041 aattgtgcaa tcatcttttc ttgatctaac agcaaaaaag gccttacagc aaattctgag 980101 gtcgaatatt gcgtaaagga ttccaatgcc tttattgatt cttcccaatg cgctaacccg 980161 tactgttcca cataatctgg aaataaaatt ccgctgagtc ctttaaaatg aggggctgta 980221 tcccgtaaaa ttgtgagcgc ttcaacgtat tgttttggca aagtttcgta taaagaaact 980281 gtcacgcggc gcatccgctc ttttaaagtg agttcaggcc agtcctccag ccgtaatgta 980341 tccaagaatc tgtttttgtt aaaatcagga taggatgacc ttacatgatg gatcaactga 980401 gatatcagtt cttcattata tatttctttt aaatcagcca tataaacacc gctttttcgt 980461 ttattattta tattgtatgg gaatgtacgt tctggatcaa gtgtatagtc ctaaaaatta 980521 acaactgatc ctaccacgga tatacaaaag ttggttactt tttttagtta aaaaaaccct 980581 tgtcatcgga aaggaaaact gagataataa cattgaaagc gcctacactt acctatttca 980641 aatggatacg gtcgcatatc atgccgttat atagagggga taagcaacag agagtaagtg 980701 ttcggagcgc atcattggtc aaacaagggg ttcctgatac atgatttttc gtaaatcgaa 980761 ataacgatat tagggagaat ggctgcttcg atcgtatcct atcaacaagc catacataaa 980821 gtctgctgag ccaggctttt tttgctttaa gaaaaggttg ttctaaacac agagacaggg 980881 tcatatccta tacacaagta cagtcatcaa ggagggggac atctctgtgt caaaacaatt 980941 gcttgcctta aatatagatg gagcgctgct tcggtcgaac gggaagattc atcaggcaac 981001 gaaagacgcg attgaatatg taaagaaaaa agggatttac gtcacacttg tgaccaaccg 981061 tcattttcgc tcagcacaga aaatagcgaa atcgctaaag cttgatgcca agctgatcac 981121 ccatagcggg gcatatatcg ctgagaaaat tgacgccccg ttttttgaaa aaagaatttc 981181 tgatgatcat acctttaaca ttgttcaagt gctggagagc tatcaatgca atattcggct 981241 tcttcacgaa aagtattcca tcggaaacaa gaaaaaggtg aattcgaatt tattagggaa 981301 agcactcatt catccgtctg acccgatctt ttatccagtc cagttcgttg aatcattaag 981361 cgatctcctc atggatgagc cggtgagtgc acccgtcatc gaggtgtaca cggagcacga 981421 cattcagcat gacattacag aaacgattac aaaagccttc cctgcggtgg acgtgattcg 981481 cgtaaacgat gagaaactga atatcgtccc gaagggtgtc tcgaaggaag cgggtttggc 981541 cctcgtcgct tcagagctgg gcctgagtat ggatgatgtc gtggccattg ggcatcagta 981601 tgacgatctg ccgatgatcg aacttgccgg tcttggggta gcgatgggga atgccgttcc 981661 ggaaattaag agaaaggcag attgggttac aaggtccaat gacgagcaag gtgtcgctta 981721 tatgatgaag gaatatttcc gaatgcagca gcgaaaagga tttcttgata agttccacat 981781 gaaacgtgtg taaaaaagcc gctcgcgccc tgacaggtgc ggcggctttt ttgccggatt 981841 gattttagca gtttatttct gtacactaaa gaaagttttg aatctgataa attaggtgat 981901 gaagttgcaa attaaaatag aaggcataca tgatgaccgc ctgcatcggc ctctgcaaaa 981961 tattgcaaat ttgttttatg aagagtgcga gcttgcgtat ggcggagagg agcccgcaga 982021 ttttgtcatt tctttagcgt tgtcacaaac ggatgagcat gtgacggttt ctggagaagt 982081 gaagggtact ggcataaagg aacagcatac aaaattcttt tctccagaca tgactgaaaa 982141 agaagctttt aagcaagtga aaaacacaat ttcttatgtg tatctcaatc ttcttcaggc 982201 gcatacgggc attacgcaga agtggggaat cctcacagga atccggccca caaagctgct 982261 tcataaaaaa ctgcaaagcg gaatgtccaa ggagcaagcg catgctgagt tgaaaaaaga 982321 ctatttaatt catgatgaaa aaatcatgct aatgcaggaa attgttgacc gtcagctggc 982381 ggcagtgccg gatttgtacc gagtaaagga tgaagtcagc atttatatcg gcattccgtt 982441 ctgcccgaca aaatgcgcgt attgcacatt ccctgcgtac gctatccaag gacaggcggg 982501 cagagtcggc tcattcctat ggggactgca ttacgaaatg cagaaaatcg gtgaatggct 982561 gaaggagcat gatgttaagg ttacaaccat ttactttggc ggcgggacgc cgacaagcat 982621 tacagcggag gagatggatc tgctgtatga agaaatggtc cgctccttcc cggatgtgaa 982681 aaacattcgt gagattacgg tggaggccgg tcgtcctgac acgattacag aagaaaaact 982741 cgccgtttta aacaaatatg acattgatcg gatcagcatc aatccgcaat cctacgaaaa 982801 cgaaacgcta aaggcgatcg ggcggcacca tacggttgaa gagaccattg agaaatatca 982861 tctgtcacgc cagcacggca tgaataatat taacatggac ttgattattg gtttgcctgg 982921 ggaaggcgtg aaggagttca ggcacagtct ttcagaaaca gaaaaactga tgccggaatc 982981 ccttaccgtt catactcttt catttaaacg ggcgtcagaa atgacgagaa acaagcataa 983041 gtacaaagtt gccggcaggg aagaggtttc tcaaatgatg gaagacgcgg tagcctggac 983101 gaaagagcat gggtacgtgc cttattattt ataccgccag aaaaacattc ttggaaacct 983161 tgaaaacgtc ggatactctt tgccgggaca agaaagcatc tacaacatta tgattatgga 983221 agaggtgcag acgattattg gcatcggctg cggcgctgct agtaaattta ttgatcggga 983281 tacagggaaa attacgcatt ttgcgaatcc gaaagatccg aaatcgtaca atgagcgctt 983341 cgagcactac acggacgaaa aaatcaaata tttagagcag atttttgaaa aaacgacaaa 983401 gcagcactga ttacagtgct gcttttttta tccctgtttt tttgcgggct gaacctcagg 983461 cttccattta aataccttgt tcagcaagcg gtaaattcgt tttgattcct ttgtgacaag 983521 cggtcccaaa atcgccagaa tgaggacata taatgcggca aacggcttta atgtggccga 983581 cagtccgccg gctatcccga gattcgcaac gataatcgaa aattctcccc gcgatacgat 983641 cgtcagcccg atattcgatg aagccttatg agaaagccct gcgcgtcgtc ctgccaccat 983701 tccggcgata aaatttccca gaatggtcaa aatcactgca cccaacgcaa gccaaaccgc 983761 ttcaccaagc gaaaacggat cgatgctgag gccgaagctg aaaaagaaca tcgcaccgaa 983821 gaagtcgcga aacggaacaa cgaggtgttc aatcctatcg gaatgctctg tttctgaaaa 983881 gaccaaaccg agcagcagcg cgccgattgc ttctgctaca tgaatcgtct ctgaaaaacc 983941 ggcgataaaa aagagtgctg cgaaaatgac gataataaac acttcgtttg agcgaatgtc 984001 caacagtttg ttcaacagcg gcgggagttt tcttgctgcg ataaaaaaca gcagcatata 984061 accgaaggcg atcaaaatgg acaagagtgc actccctacg gatgtcgcat cacctagtat 984121 aaggccggaa acaacggaca gatatacggc aaggaaaata tcttcaaaca tgatgatgcc 984181 gagaatcaat tcggtttccg ggttggcggt tctttttaaa tcaacgagca cttttgcgac 984241 aatcgcactt gacgagattg tgatgacgcc tgcgaggatg aggacttcca gaaaggaaaa 984301 tccggtgata aacccgtaaa gcagtccgag gctgaagtta atcaaaatat aaatcgtccc 984361 gccgaccgcg attgattttc ctgatttgat taacttcccg acagagaatt cgagtccgag 984421 atagaagagg aggaacagta cgcccattcg cccgaaaaac tcgatgattt cactgctttg 984481 aataaatgtt agatcaataa tccccatttt cggcgcgtgc ggtccaacaa gcattcccag 984541 cacaatcaga aacggaataa tcgaaaattt aattttattg gcgatcacac tggcgattgc 984601 cacaagcaca agtgcagttc cgacttcaaa tacaagatgg tccatcgggg ctcacacgcc 984661 ctctccagaa agaaaatcgt gaatcagttt cttcagatgc tttctctcac ctgagaggac 984721 aagggtgtca ttttcttcaa taatcgaatc cgctccggga tttaggagct tttcctggtt 984781 gtgtttgata atcgcaataa cagtgacatc gtaattctgg cgaacatcaa gctcaccgag 984841 tgtgcgtccg atcgatttgg cgcctttttc gaccttaaac cattcaataa taagatcgct 984901 gaaggccatt tcgatggact ccagagcttg cggtttatag accatgcccc cgagaatagc 984961 tgcaatttgc cttgcttcag aatcatccaa tgaaatattt gaaagaagct catccgggtc 985021 ccggtcatta aaccggtaaa tttcccttct tccgtcatca tgaatgataa tcgtcatttt 985081 ttcgtggctt cttgtttcga tttcaaactt tttgccgatg cccggcagat cgttttcttt 985141 aatattcaat gaaaatccct ccgaatgtag tgttggcagt atggggtgag ttacaaataa 985201 aacttgagca aattatattc ggaggtaatt agactggtat ttgacaggga cggccaaagc 985261 cttttccagc ctgtttatca gcggttcgtc aagtggtttg acagagagct gcctgacaga 985321 ctgcgccagc gggctgtact ctttgatcag ctcagccggg tgcatgctgc ccggcgatgg 985381 cgtttttgcc gattgtgttt cctgcggata tgaagacata ggcacatagc tgtcagtgct 985441 tgcttcaaac tgggaaggca gaaccacgtc cgaaggggga aagtacacca taaataaact 985501 taacagaaaa ctgatcagca atttatccat gttcctttcc tcccttctca tcaagatatc 985561 ccttcttttt cactatataa aactttatgt ttccattcaa acaatatgca tttttcagta 985621 tctattgacc ttgaaaaata aaaaggttta tttggggatg gcggggaatg tataggagaa 985681 agaaaaaagt aagcgcatac atggaggtgc ttttaatgga gtttgttcaa tatgcatgta 985741 atggggccgt tgcagagatt atcctgaatc ggcctgatgc ccatcacgcc ctgaatgaac 985801 agatgctgtc tgaattgaag gaggcagtcg aaatggcggc tgcaagcgag gcgctcatcg 985861 ttctcctgag aggaagcggg aaaggctttt cggccggcgg tgatatcagg atgatgacgt 985921 cagagcatga ccctgaccaa tttaaacggc tgatggatac gattgaggct gtcaccctga 985981 atttatatca gatgaagaaa gtgacaattg cagccattca tggtgctgct gcgggactgg 986041 gcctgagttt ggcgctttgt gcggacattg tgctcgctga aaaaaacgcc gttctcgcga 986101 tgaattttat cggcattggg cttgttccgg acggcggagg acattatttg ctgaagaaaa 986161 gaatcggtga agcaaaagcg aaaaaactga tttggagcgg aaaaaaacta tctgcctcgg 986221 aagctgccga tatggggctt cttgatggga catttgccgg agaccctgcc gaaggcgcaa 986281 gacccattat cgaaaccctg ttggcctccc ctcttttggc gatgatcgaa acgaaaggta 986341 tttttcaaag cctccaaatt gaagaactga aaaaagtgct atcccttgag cgcagcgccc 986401 aagagagaat gagaaggacc aaggatcacc aagaaggaat ccgtgccttt ttagaaaaac 986461 gggagccgaa gtttcaagcg taacagatca gccggaaagc tgatcatctg tgaaacaaaa 986521 tcagctttcc ggctgcattg actaaacgat gagtatgact atgaagctct ttttctttta 986581 agagggcttc accatgcgtt tttgccgctt cttcatgttc tgcctcgaat tgctcgttta 986641 ccagcgtgtt ccccgaagga tcaaatacgg taaggaaata atcagccatc aggtttctcc 986701 tccattttaa ggtttatcag tctttcttca tttatattct aaaaaggaaa tcaaaatcct 986761 ttattatgct ttatccaaaa ttagtatata atgggtcagg gaaggaggag attcagtgct 986821 tacaattgat cacgtaacga agacatttgg agattataaa gccgttgacg gattggactt 986881 agatattccg gaacagcaaa tgttcggtct attaggcgca aacggagcgg gaaaaacaac 986941 aacgtttcgc atgatcctag gattattaag cattacggag ggctcaatca gctggaaggg 987001 ccgtcctgtg aattatcata tcagcaacaa aatcggttat ttgccggaag agcggggcct 987061 ttatccgaaa atgaaggtaa gggatcagct cgtctatctt gccagattaa aagggatgga 987121 gaagcgagag gctgtaaaag agctcgggac atggcttgaa cgcttcaata ttacagatta 987181 cgagaataag aaggtggaag agctttcgaa ggggaatcag cagaaaatcc aattcatttc 987241 ggcagttttg cataagccgg agctcctgat tcttgatgaa ccattcagcg gcttggaccc 987301 tgtcaatgtt gagctgctaa aagaggccgt gatctcgctg aaaaacagcg gtgtttctat 987361 tttattttca agccatcgga tggaacatgt ggaggagctt tgtgagaacc tttgcatatt 987421 gcagaaagga aaaccggttg tacaaggcaa gctgaaggag atcaagcgtt ctttcggtaa 987481 aaagaatgtt accattcact ccgatgacga tctgcgcttt ttgcagtccc atgaaggcat 987541 tcttcaatgg aaggaaacgg cagacggcgt caagctgcag attgccaatg aagacatttc 987601 tcaagagatt tttgcgatgc tccaaggaaa agggtttatc agaaagtttg agcttgaaga 987661 gccgtcactg catgatattt ttatagaaaa ggtgggggcc gtctatgaat aaattttgga 987721 tcatgctttc tcatacatac aaaaataaga ttatggcaaa atcctttatt atttcgactg 987781 tcatcacggt gctgcttgtt ttagttgtaa cgaatctgga gtcgatcatt tctttgtttc 987841 aaggtgacga tgcgaaagaa aaaatcgccg ttgttgatga aacaaacgaa ttatatccgg 987901 ttttttctaa gcagctgaaa gcggtggata cagacggcga tcttgatgtg aagctgtcga 987961 agcaatcgga ggatgaggtc acaaagcaag tcaaagatga atcactcgat ggcatgctca 988021 tcatcaaacg agatgaaaaa gggaccattt caggaacata taaagcgtta acgatttctg 988081 atgaaagcac gtatcaaaca ctgcagcagg cgctgacgca aaccaaaaca gctgtcggaa 988141 cagcggagct cggcgtgtcg caggaaacga ttagcagcct ttatgcgcct gttactgtgg 988201 ggcagaaggc gctgaaagaa ggggcaaagt ctgaggaaga gcttggccag acggtagggc 988261 ttgtttacat tatgctgttc gtcatttatt tctcggtgat tatgtatgcc agcatgatag 988321 cgatggaggt cgcaaccgaa aaatcttcgc gagttatgga aatcctgatc tcaagtatgc 988381 cgccgatcca gcaaatgttt gcaaagctgc ttggtatcgg gcttgtcggg atcacacagc 988441 ttgctattat tataggagcc ggctctctgt cgcttaagct gaaccaaaag agcgaaacgg 988501 cttcatctgt cggcggattc cttaatttga ccgacgtatc tgcaaccact gtcatctatg 988561 ctgtcatttt ctttttgctc ggatactttt tgtacgcgac acttgccgcg tttctcggca 988621 gtgtcgtcag cagaatagag gacgtgcagc aaacgatcac gccgatgacg cttttggttg 988681 tcgccggttt tatgatcgcg atgttcggtt tgaatgcgcc tgacgcagga tttattacgg 988741 taacttcgtt tattccgttc tttacgccaa tgattatgtt cctgcgcgtc ggcatgcttg 988801 atattccgtt ctggcaggcg gctgtcggaa tcggaatcac actgctcacc attgtcatac 988861 tggccgttat cggcgccaga atttataaag gcggtgtatt aatttacggc aattcaagcg 988921 cgttcaaagc gatcaaacaa gcgctacgtt tagcgaaaaa ctgattggaa aacagcctgg 988981 ggattctcag gctgtttctt tattgacaga acgtgcattc gcaagaattc ggtgctaaaa 989041 taagggtact tcatcctgga aaggagcaga atgttgactg atctaacctt tattcatgcg 989101 gcagatcttc atcttgacag cccgttttac gggatatcgc atctgccgga gccgattttt 989161 gcccggatta aagaaagcac gtttgcaagc gtgagacata tgatagacgc cgcagtgaga 989221 gagcacgttg atttcatttt gcttgcggga gatctgtttg atgaagccaa tcgaagctta 989281 aaggctcagc tctttttgaa aaaacagttt gaaagactca gagagtgcgg aatttcggta 989341 tacgtcatct ttgggaatca cgatcatctt ggcggggagt ggacgccgat tgaatggcct 989401 gagaatgtcc atattttttc gtccgctgtt ccagaagaaa aatcgttttt taaagaaggc 989461 aggcgcatag caagcattta cggcttcagc tatcaagcca gagcattgat ggaaaaccaa 989521 gccgcccgct atcggagatc aactgacgca ccgtttcata tcggcatgct ccacggcacg 989581 ctgtcaggat ctgaaggaca cgatccgtat tgcccgttta cacatgacga cctcgtgaaa 989641 agcgggatgg attattgggc gcttggccat atacataaac gccaggttct atctgccgag 989701 catccggcag tcatttaccc gggaaacacg caagcacgcc atataaagga gacgggagat 989761 aaaggctatt atctcgttca tgtgacaaac ggagatatat cttatgaatt tcagagagcg 989821 catgatgtcc tgtgggaaaa agcggcggtt gatgtgacgg aggcaaagaa tatgacagcc 989881 ctcttccaaa tggtggagga cacgttttcg aagctgcgga aaaaggggag ccctgtttgt 989941 gtaaggcttg ttttacaagg gacggcgccg gaatggctgc tggaggcgcc aaaaggcacc 990001 ttggatgagt ttcttgaagc tcttcaggaa caagaagcgg aagaggaacg tttcgtttgg 990061 cctcttagat tggacgatga gacagaaaac gaagcaaacc taacaaacct tgatcctttt 990121 tttggcggtt tatttgaaga cattgatcgc agcgatctgt cagacgtgct ggaagggctt 990181 gagcggcatc cagtgtatag aaggcacgcg gaccggttta gccaagagga ggtaaaggaa 990241 ataaaagagc aggcacagat aatattgaaa agacagctta aggtgcttga tacatgaggc 990301 ggtgacagct ttgcgaatta tatctttaca tatctaccaa tacggaaaat tttccaatcg 990361 gacctttgac ttttccgcct ctcctgtcca agtcatctac ggattaaatg aggcaggaaa 990421 aacgacgatg atgtcattca ttgaaagcat gctgttcggt tttccgaaaa cgaaaaagta 990481 tgaaccgaaa acaggcggtg tctacggcgg tgttcttgaa gctgaacatc ctgagtatgg 990541 ggtgctgaag atcgaacgga cgaaagggac tgccgaaaaa ctaagcgtgt acacagaaaa 990601 gggcgaagta aagcagggag atgttttaaa gcagctgttc cagggcacag acaggtcgtt 990661 gtacaaagcc atatattcgt tcgacgtatt cgggctgcag gaaattcacg cctttaatcg 990721 ggacaagata ggggaatttt tgctcttttc cagcttgttt ggtgctgaag ccgtatcaaa 990781 gcttgattca aggctgacga aggaaagcga aaggctctat aaaccaaatg ggcgaaaccc 990841 tcaattgaat caggagctgg aaacgcttaa gcagctggca gttaagctaa aacaggctga 990901 agcagaggaa gcgggctatc atcagcttct cgaggaaaaa cgaacgcttg aagcccgcct 990961 tgcagccgcg gaaaccgaat tgaaagagac ggcgggacat atccgaatga ttgagggagc 991021 gattgagcga aagccgctgc taaatgaaaa agcgacactc gaacaggtga ttgcagaatt 991081 tccggaacac gcaggacaat ttcctgctga cggactgcat cagctggaaa aatatgaatc 991141 ccatcttcac ccgaaatcag cacagcttga ggcgcttcgg gtgaagatgg cggagttgga 991201 caaacagagg caaaagctta tccccgataa agaactattg gcgaaagaaa cgctgataca 991261 agagctttcg gcagcgtttc atatgtacca atcctgggga gaacagctgg cagccattca 991321 ggcacagctg cgccagacgt ctgcgcagac agcggcaggg ctggaacagc tcaataaaac 991381 ggatgaaaat gagctcctga atatgaacac ctcatatgat tatgaatggc agcttcagca 991441 agcggtgcag caatatgtac aggcaagaga cagaaaacgg cagcttgacg agacgtttga 991501 acttgcccgg caagagctgg aagacgcgga aaaggccgtt cgtgccgctt cgtccgcgat 991561 tcttgaaaac agccaaagaa aagataaaga agcagctctt agagcatatg atgaaacaca 991621 ggggcagcac caagagcaag cgaagctcag agaacagcta acgttttttg aaagacagca 991681 ggctaaacag aaaaagactg tcattgcagc tggtatgttg ttcatcgttc tcttttctct 991741 gctgcagcaa tggattcccg ccataagttt cggcgctgca cttattgtgt attggcttgt 991801 ttcaggaaag tcgtcttctc gaaacagccg agagacaaga cagcccatga cggatatttc 991861 accagcagaa gctgaaatgc ttagagaagc gttatgggag gatgaccgca ataagcagca 991921 ccttctcaca cagcgtgcag cgctccagca aaaagaggcg gcgtatgaaa gggtcatcca 991981 gcagtttgaa cagtgggaag ccgaaatggc gccgtccttt acacaggttg agcgttttat 992041 gaatgagctc ggatttaagg aagatccatc atttttgctt gatgcataca gcttaatgaa 992101 ggatgttaaa aaagaagtga agaaaaagca tgagctgacc atagaagcag gcaggctgaa 992161 aaagcaccgg agaacattcg aagaacgcgt cagtatgctt cttcccgtga atcagagtca 992221 ggatatctcc atttcggacg cccttcacac attgcggaaa aacattgaac gtgaaaaaga 992281 aattgagaag caaaaaaagg aaattgaaac agatattcat tatacaaagg aacagatgct 992341 tgaacttgag caagaaatac agtatttcca cgcacagatt gaacagttat ttgccgcggc 992401 tgctgcaaaa gacagagatg cgttttttgc catagccgcc atcagcaggc aattgaagga 992461 tacggagaac aagcttcatc acgtaaacgc acagcttcaa ggcgggtacc cggaggaact 992521 tgaactggcg gattccaata cgctttctga attgaaagat aagcaatttg ttgagaatga 992581 aagaaaagag cggctgactg aggagatcga gcagctccgc agccaaatcg cactgctctc 992641 agtcaaacag gaacaattag aggcttcggg aatggtctca gacctcaagc ttcaaaccga 992701 aatgcaaaaa gaacgtgtga aagaaacggc taaaaaatgg gcctccatac aaatggtcaa 992761 acaggtgatc agaaacaaat tggagcggca taaaaaaatc gagcttccgc gccttctgga 992821 gacggcagga gaatttttcc gtcctctgac tgacggaaac taccaaacca tttatttttc 992881 cgaaacggat gattcgatca tggttatgca tcgcgatggc actgtctatc atgcggaaga 992941 gctgtcacaa gggacgtgtg aacagctgta tacagcgatc cgctttgctt tggccgttac 993001 gcgccagggt gagtcaaagc ttccgttcca gcttgacgac agttttgttc attttgatca 993061 ggaaaggctg aaacgtgtat tacatgttct gtatgattta tctgaaggcg gtaggcagat 993121 tttgtatttt acatgccatg agcacgtaaa agatgcattt catagcagcc aaatcatcca 993181 tttggtgtca taaaagaggt tctatagctg aaaatcggta tgtgatatac tggtattatg 993241 taagatacgg agggagcttt aatagaatgg ctaaagggat tatgctacat gaggttggcg 993301 aacaggtgga ccagtatcta ttgattaaat cctcgacgaa agggattgca agcaatggaa 993361 aaccgtttct gacgctgatg ctgcaagacc agtcaggcga tattgaagcg aagctgtggg 993421 atgccaagca aagtgatgaa gtgacctatg cgccgcagac gattgtcaag gtcgtcggcg 993481 atgttcacca ttatcgcgga cgcacccagc tgaagctaag aaatatcaga ccggtaagcg 993541 agcaagaaaa cgtcaatatt gatgattttt tagaaaccgc gccgattccg aaaaatgaaa 993601 tgatggatac catcactcaa tatatatttg aaatgaaaaa tccgaatatc cagcgaatca 993661 caaggttttt ggttaaaaaa cacgaagctg agtttatgga ttatccggcg gctacgaaaa 993721 accaccatga gtttgtctca ggtttggcgt atcatgttgt ctctatgctg aacctggcga 993781 aagcaatagc agatttatat ccttctcttg atcgtgatct gctttacgcc ggtgttatcc 993841 tgcatgatct tggaaaagtg aaggagctgt ccggccctgt ttccacttca tatacggttg 993901 aaggcaattt gctcggccat atttccatca tggtgacaga gctttcaaaa gcggctgagg 993961 agcttcaaat cgattctgaa gaggtgttaa ttcttcagca tttgattttg agtcaccacg 994021 gcaaagcaga atggggcagc ccgaaaccgc ctatggtgaa agaagcggaa attcttcact 994081 atatagacaa tctggatgca aaaatgaata tgatggacag agcgcttgag cgcgtgaagc 994141 cgggcgagta tactgaacgt gtatttgcac tggaaaaccg ttccttttat aaaccgacat 994201 ttcataaata acttaaaaag gactgatgct gacatattca gctcagtcct ttttgatgcg 994261 tctttcccgc acataactcg tctcattccc gcatatggtt aagaataaag aatctatgca 994321 aagggggagg agcccgtgtt attttttccg tggtgggtgt atctttgtat tgtaggcatc 994381 attttcagcg catataaact tgtggcggca gccaaagagg aagaaaaagt agaccaggct 994441 tttattgaaa aagaaggaca gatttatatg gagaggatgg aaaaggagcg agaacgccgc 994501 agttctcagc agcatgaaga agaaaatcaa aaccattcca tcgcataaaa aaagctgtgc 994561 ggctcaatga gccgcacagc tttttttatt atttagaatt gcttgaagat gaagaagtgc 994621 tgttgcttgt tgaagatgta ttaaatgtgt ctttcagatc tttatctttt acttcgatgt 994681 cagccttctt catgactttt tgaacagctt cctgaacagc tgcgttgtca tttaattttt 994741 gttcaagcac ttcagatttc agttcttttt tcatatcatc atatttgccg cgttcttctg 994801 tctttttaat gatatggtag ccgtattgcg ttttgacagg atcactgact tcacctgttt 994861 ttaatttgaa tgcagctttg ctgaatgttt cgtccatttg gccttctttt gcgaaccagc 994921 caagatcccc gccttttgaa gcagagctgt ctgttgagta ttctttcgca aggtcttcaa 994981 acttctcgcc ttttttcagc tttttctcta cttcttcagc tgtcttttta tcagcaacaa 995041 ggatgtggct tgcacggatt ttgcctttta agccttccca gtactctttg atatcggcgt 995101 ctgttacttt gatgttatct ttagccgctt tttgtgtcag caattcatat tttacttgtt 995161 ctttcaggta atctttgcca tattgctttt cgagggcagt atattgatcg ccaagctgcg 995221 ttttgtattc tttcagcttg ttgtcaattt ctttatccga aactttatac ttcttgtcca 995281 atactttttc ttgcactagc tgtgtcagta cgcttgcgcc agctgttttc ttcatgtttg 995341 tgtaaagctc gccttttgtg acatcgcctg cgtctgtttt tgcgataact tctttgtcgc 995401 cgctgctgca agcactgaga gcgaggatgc ttgtagcagt gatagctgct attgcgattt 995461 tcttcattgt tttcaaacac tcctaatcat tccaaattaa attacctatg cgtatcataa 995521 catattgtgg ctttctgtaa aaagatttta aataaagggc attcgtctag tcaaactttt 995581 gctgatgaca tacttatata ttgatcaaga aaaggaggta tgtaacatga gcggaggata 995641 ctctaacgga ttcgcgttgc tcgtagtact gttcattttg cttatcatcg taggtgcagc 995701 ttacatctac taagcagccc gaggatcgct tgcaacataa gcgatccttt attttcacta 995761 gcgcctaatc gtttcaaaca tgaattgcat aacatgtaat tggtaaataa agcttattac 995821 aggaggtgct atttaagatg ggtgaagtat ttgcaggcgg attcgcttta ttggttgtgt 995881 tatttatttt attgattatc atcggcgctt cttggctgta ctaatcaaca taaaaaagca 995941 tagctgctta atcagcagct atgctttctt tcgtatttac actgtaaagg agatctccac 996001 aaacgaagag atcagtaaaa ttaatataga tacattaata aatcggaata ccttatcttg 996061 ccgctcttca ggaatctctc tgacaaggca taatgtattg gtgagcctgt ttatgaaata 996121 taaaataaac acggcagcca cgataaaata gaataaaatg atgggagatt ccccctctct 996181 ctgaactgtc ccatattaca ttaccaaata tttattaaaa aagatagaat gcaaattgaa 996241 aaatcgccac cagcaccagg gtttgactac ttttcaacaa gaatatccaa gccgtcagct 996301 tcctgatcaa taaaagcggt tttcggtgct tttatcagct tgagagccag caggaaatca 996361 ggcagacagt agccggcgtg aatgcccgag atcatgcaaa aataatgagc gtgattcgga 996421 aatgccagtg ctgcgtaaaa caataccggt gtaatcagca agaacgggct gacgagtgaa 996481 atcagcattg ttgtttttgg tatacgtttc catgtgcgca tgcgcaatat gtaaaacttt 996541 ttttctattt ttcttttttt gcagatgatt ggcaggacat ggatgacttt atgtacaaat 996601 aaaataacga cgagcaaacc gccgaataaa gatacatatt catcgcttaa gcttgtgcca 996661 ggccgcagca gctcaaaagc taaaaaggta gatataaaaa ccaaaatcat aaaacataca 996721 gcagttaata ttatgcgaac ggcgccataa tccttcatga gatttatggt cttccagcaa 996781 ttcatcaaag tcatccttcc atacatcttg aatagaatct caaaataatt tactcctccc 996841 aagagaaaaa atcaatgctt ttttaagaaa aaatatcatc cggcaggtat ttttttgaaa 996901 caagcaaaca aactgcgaaa tatggggtta gaactttctt ctcagtgaat tatcagctaa 996961 aataagatta aagatagaaa gaagtggtgt ggatggattc gatggatcat cgcattgagc 997021 gattagaata ttacatacaa ttattagtga aaacagtaga tatggacagg taccccttct 997081 atgcgcttct cattgataaa gggctgagca aggaagaagg ggaagcggtt atgaggatat 997141 gcgacgaatt gtcggaagag ctggcaacac aaaaagcgca aggatttgta acctttgata 997201 agctccttgc gctttttgcc ggacagctga atgaaaaatt agatgttcat gaaacaattt 997261 ttgccctgta tgagcagggg ctttatcaag agctgatgga agtctttatc gacatcatga 997321 agcattttga ttaactgttt acaggttcga gctcttcagc cggttcatcc gccgcactgt 997381 cctttgcttt tttcttcaat tttccgttta cgctttcaaa gtcattgtca atattggtga 997441 gtgacgtttc gaaaatttcc ataaaatcat cgccgtagat atggcgtatc atacacatca 997501 tttctgccac ttcaggaaat tttccgaata aatgatataa aggctgtgac cctttaaaaa 997561 cagcgttgcg tgtcggatca aattcctcaa gcaagctcca gaatacctcg gtaccttcct 997621 cagtcaattg gacatatgtg ttccgtttat cattcagccg tttggagaac cttaaatatc 997681 cccgttcttc cagctttttt gaaaagttga atgcggttga tacgtgcatg accccgaatt 997741 tcgcgatttc agaaatggaa gctccattca attgatacgc aatccataaa atatgatgct 997801 cattaatatt caggtcatac ggtttgagcc attgctgcca atccttctcg atcgatttcc 997861 aaagagcctt gctaagctga gccattttct gggtgaaaac cagagcttct ttcacatcat 997921 agggcggttc cactcgattc attacgtcac ctgcttctct ttttcttttt ctctattatg 997981 ccaataaaat aaagattaat aaagatgaaa atgtaagaat tttttaataa attcacaaac 998041 cattgcgacg aaagggtttt tcggccaaaa aaaatacggg tccaattttg gcccgcattt 998101 ttttcttttg aataggatat tagttttgta aggttttctc cagctgtctg attttctctt 998161 cgatatcggc aatttctttt tgcagatcct gctggtgagg cttgatctct tcctgccatt 998221 ttttaattga tgtttggagc tcgccgccca cgtctttaat aacatccgtg ctttcttttg 998281 ccgctttgat cagctggtct tttaatgcaa gcccgtctga ctttaagcgt ttgattgttt 998341 cttcaaaaga atcataattg gttttcattt tttcacgcag ctgctttcct gaggaaggtg 998401 cagtaagaag aaccgctgct cctccgatga tgccgcctac gaatagtcct gttaatagag 998461 aacgtccgct cgccattaca atcaccccgt ctttttcttc aaaataggat tcattcagca 998521 tttttcattt ttgttgaaag cctgaacttc tatacatagc ttgctttatt ttagcatatt 998581 ttttaagtga aaaggaggga gaaggttgtc tgtctttttg attgtattat cctgcatcac 998641 ccttgccttc gcttcaggcg ctgtttacta tatcaaactt ctcagccagg ctgcttctta 998701 tccgcccaag agggttatcc ggcagaaagc gcttgtttgt tcaaccggaa ccgcctttac 998761 actatgtctt atctttttca caaaactcct cgcttaaaac atgctgacat gctgcgggcg 998821 ctctgttcaa aaaaacctct cccggaagcg gaagaggttt tgtgtgacaa ttatttagca 998881 gcttccataa agcttgaacg ccttaaaatg gtttgcacaa tcggataaat aatgatcatt 998941 gagattgtat tcagcacagc ggccggcaga acaacagccg cgaacaatgc ggcgaaaccg 999001 cccggtaaac cgacgatcaa taaagctgac gatagaaaca caattcctga taagatggtc 999061 ccgatcactg tcagcacagc ggctgcacct gttttccggc tctttctgaa caagagaaac 999121 agggagaaga acagaaacgc tgatacgggt ttatcaatga tgttagggat ctgtccggct 999181 ggaaacgcgg ttgtaagcgc ggaaatgatt ccggtcacga tcccgatgac gagtacattt 999241 tgcacccgcg ggaacagcag aatgcccatg aacatcatga tcagcatcat atctggtttc 999301 atgccgccta aaaagggcgg aataatggaa tgaagcgctg cgccgattgc ggcaaacaga 999361 gccataatga ctaactcttt tgttttcata actatgctct cctctgctaa gctttttgcc 999421 ctccaataat atgctcatca tttattgcga aggctttaca gaatgtgtta tgcaaacagt 999481 ataccaaacg gacggtttgc atagccagac tttttactca ttttcctgct ggaatttctt 999541 catgaacgca gctaattttt cacagtcttc gagagagacc gcgttataaa tagaagcgcg 999601 gcagcctccc accgaacggt gtccgccaag gccgatcatc ttcgcatctt ttgctttctg 999661 aacgaatgtt ttcgttaatt cgtcatcccg aagcgtgaat gtgacattca tgcgtgagcg 999721 gctgtctttt ctggcatgtc ctttatagaa gccgttgctt tcatcaatac agctgtagag 999781 aacctgcgct ttttgttcat tgcgctgttc aacagcttcc acaccgccgt tttccttgag 999841 ccattccaga acgaggctca gcatataaat cgcaaatgtc ggcggagtgt tgtagagtga 999901 atccgctttg acatgcgtgg aatatttcaa gatttttggg acgttcgcat tttcattttg 999961 cagccagctt tttttcatga tgactacagt cacgccggaa gggccgaggt tcttttgggc 1000021 gcctccgtag atcacatcaa atttggacac atcgattttt ctgcttaaaa tatcgctgga 1000081 catgtcggct acgagcggaa ttggagaatt cggaaactcc tgccactgag tgccgaaaat 1000141 tgtattgttg gatgtgatat gtaaatatgc gccgtctttt acatccgtaa ggtcaacctc 1000201 tggaatataa ctgtaattgt ctgtttcact tgtagcggtg atagacgtgt tcccgaacag 1000261 tttcgtttct gccagtgctt tttcagacca agcgccggtc atcacaaaat gtgcggtttt 1000321 ttcaggtgtt aaaaagttca tcggaagcat tgagaattga aggcttgccc cgccttgaag 1000381 aaacaagata tcgtaatctt ccggaatgcc catcagttcg attaagaggc ttttcgcttt 1000441 ttggtgcacc gcttcatact ctttgctgcg gtgggaaagc tccataacag acatgccgga 1000501 ttcgttaaaa tcaataaatt ctttctgtgc tttttgcaga acttccagtg gcagcgctgc 1000561 aggacctgcg ttaaaattcg ttgtacgttc cattatgatc tctccctgtt ttccacgtta 1000621 atgtataaaa taatacaatt atcctatcac aaaaattcag ttttttgata aaaaattaga 1000681 attatcaaaa gaaattgacg gatgtttgcg aaatgttcac aaaataaaat aacctcatct 1000741 tatgatgagg ccaggcgttt tgcgatagag gaagagatgt tctgcagatc ctccggttta 1000801 taatcatcag catgcgtttt ccaaaccgct ccgaatccat ctccttttcc gtagcgaggg 1000861 ataatatgca tatggtagtg gaacacagat tgtccagctt tttcgccgtt attgttcagc 1000921 gtatttaagc cgatcggttc aaattcatcc cggatagcgc gggcgatttt tggaacagca 1000981 tggaaatatt gttttgctaa ttcatctgta aattcatata cattctcaat atgtgttttc 1001041 ggaatgacaa gcgtatggcc ttttgtcact tggctgatat caagaaaggc aagtacatgt 1001101 tcatcttcat acaccttcgc tgatggaatg tcgccggcaa taattttaca aaagatacaa 1001161 ttctctgcac aatgcatgag ggttcctcct tatgaaattg tttagtatgt atacattcat 1001221 cgtaccacag aaatgcagaa aatagaaaac aggatgaacg gcgagcgttc accctgaatg 1001281 cagaggaaga gcttatatga agaaaatgtg ttatgccttt ggtaagcacc tcatttgtca 1001341 ataaaatgaa gacttgttta atgcctaacg attcctgcga taaacacctc atttgacaat 1001401 ttgcttcata catgaagaat tcatcaattc agtgaagaga aatggtttga gcattggaca 1001461 tgtttatttt ctatccaact gtttctaaga cgtctttgac aaacacctca tttttcagtt 1001521 gatatgcttt tcctctacaa cttttatgat gtccagaacc ctgtctcttt atgacagcaa 1001581 attcatcatt tgttaaaagg gaattgtttc aaatcaggcc ttgtttttgg tactatgaag 1001641 aaaaacacta taaggggaga aactatgtct ctgctatcgg taaaagactt gaccggcgga 1001701 tatacaagga atccggtttt aaaaaacgta tcattcaccc ttgaaccgaa tcaaattgtc 1001761 ggcttaatcg ggctgaatgg tgctggtaaa agtacaacaa tcagacacat catcgggctg 1001821 atggacccgc ataaaggttc aatcgaatta aacggtaaaa cgtttgctga ggatccggaa 1001881 ggctaccgtt cacaatttac ctatatacct gaaacacctg ttttatacga agaattgacg 1001941 ctgatggagc atcttgaact aacagccatg gcatatggac tgtcaaaaga aacgatggag 1002001 aaaaggctgc ctccgctact aaaggaattc cgaatggaaa agaggctgaa gtggttcccg 1002061 gcccattttt ctaaaggaat gaagcagaag gttatgatta tgtgcgcatt tttggcagag 1002121 cctgcgctct acattattga tgagcctttt ctagggcttg atccgcttgc cattaacgcg 1002181 ctgcttgaac ggatgaatga agcgaaaaaa ggcggggcga gcgtgctgat gtcaacacac 1002241 attttggcaa cggcagaacg ctattgcgat tcgtttatta ttttacataa cggcgaggtg 1002301 cgggcgcgcg gcacgctgtc agagctcaga gagcagtttg gaatgaagga cgcggcgctg 1002361 gacgatttgt atcttgagct tacaaaggaa gacgctggcc atgaataata tgcttgatat 1002421 ttggcagtcg cggctgcagg agcatatcaa agaaacaaga acatacatga aatatatgct 1002481 caacgatcac ctcgtcattg ttttgatttt ttttctagcg ggcgctgcaa gctggtacag 1002541 caaatggata cgggacattc ccgctcactt tccgtccttt tgggtgatgg ccgtgctgtt 1002601 ttcgctcgta ttgacaagct cttatgtgcg aacgcttttg aaggaggctg accttgtttt 1002661 cttattgcct cttgaagcaa aaatggagcc ttacttgaag caggcgtttg tctacagcta 1002721 tgtgtctcag ctgtttccgc tgattgcgct gagcatcgtt gcgatgccgc tttatttcgc 1002781 agtcactccg ggagcttcgc tcgtatcgta tgccgcggtc tttgtccaac tgttgctgct 1002841 gaaagcgtgg aatcaggtaa tggaatggcg aacgactttc caaaacgacc gcagcatgaa 1002901 acggatggac gtcatcattc gctttgcggc gaatacactc gttctttatt ttgttttcca 1002961 atctgtttat atgtatgcgc ttctcgtcta tgtcattatg gctgttcttt atctgtatat 1003021 gtcttccgca gcaaaacgga aaacatttaa atgggagagc catattgagt ccgaattgag 1003081 acgaaagcag cgtttctatc ggattgccaa cctgtttact gatgtgccgc atttgcgaaa 1003141 gcaagccaaa cgcagagctt atctcgactt tttgctgcgg cttgtgccgt ttgaacagcg 1003201 caaaacattt gcctatatgt tcacccgcgc ctttttgcgt tcgagcgatt atttgggcat 1003261 tcttgtcaga ttaacgatcg ttttcgcgct gatcattatg tatgtctcag ccagcccgct 1003321 gattgccgcg gttttgactg tgtttgccat tttcattacg ggcattcagc ttctgccgct 1003381 cttcggtcac tttgaccatc tggcgcttca agagctgtac cctgtgcaaa aagaaacaaa 1003441 gctgaaaagc tatttctctc tattaaaaac tgcacttagt attcaagcgc tgctgatgtc 1003501 tgttgcatct gcctatgcag ccggcttgac cggttttctg tacgcgctga tcggttctgc 1003561 cgttctgatt tttgttgttt tgcctgctta tatgacgacc aggctgaaaa agcacggaaa 1003621 gctgtgaact gaaaagaggt aatcaaatga cagataatca gctgctgatg caggaagctt 1003681 tggaatggaa aatgcatttt ttgcgaaagg attccatgtt tgaacgcttt tcgaagcgtg 1003741 tccagacgaa ggtgaatgaa cggattcctg aaaaaatcca tacggtcgtc accgagagtg 1003801 tgaaaaaaat ggtagaagcg acaatggccg gctctaatat catcacctat aaaaaggata 1003861 caagtgcact gtcgctcagt gaaaaaaacg aattggcgaa aaaaacgatt gtttcttatc 1003921 aaaaagtggc agctgctgag ggagtcggca ccggagcggg cggcattttt ttaagcattg 1003981 ctgattttcc gctgctgctt tcaattaaga tgaagtgttt atttaccttg tcttccattt 1004041 acggctttga tgtcaaggat gcacaagaaa ggatattttt gctgctcgtg tttcagcttg 1004101 cgttttcgag tgatgatggc cgtaagtcgc ttttttctgt catcgaaaat tgggagacgg 1004161 agaaaaagag catcgactgg agagtgttcc agcaggaata tcgcgattat atcgacgtcg 1004221 tgaagctttt tcagcttttg ccgggcgtag gagcggcagt cggcggaatt gccaattata 1004281 agctgcttgc tcagcttgga gaaacggcaa gacatgtttt tcatctgagg atattaaagg 1004341 aaacagccgg agaataaaca ctccggctgt ttttttatag ctgatgatag gtgatcgcag 1004401 cgccggcaag gaccttggcc gctgtcagca tggctttttc gttgatatca aatttcggat 1004461 ggtggtggga atagactcgc tctggctgtt cgggagcggc gcctgtaaag aaaaaagtgc 1004521 ccttcacgtt ttgtaagtaa taagcaaaat cctcgccgcc catttgtggt tcaccgtcaa 1004581 tgacctgctg aacgccctcg gtattctttg cggtgctcac caagtggttc gtttctgcag 1004641 gatggttcac aaccgctgga taaccctgtt cataggtgta ctcataggac gcgccgtgca 1004701 tgctgcatat tccttttaca accgcttcaa tttctttctc cagaatgtcc cggacatttt 1004761 catcaaaaga acgcgctgtg ccgatgagta ctgcttggtc tgcgatgaca ttaaacggat 1004821 tgtcggcgat gaaggagcct gtcgaaatga cggcggattg aatcggattg actttgcggc 1004881 tgacaatgtg ctgcaaagag gaaacgattt gcgaaccgat taggacggcg tctttagtat 1004941 catgcggatg agcgccgtgg ccgccctttc cgaagacttt aatcgtaaat cggtctgccg 1005001 ccgccattac ggcgccgggg cggcagagaa tagttccgag cggctcagtt gcccaaagat 1005061 gagtgccgaa tatcacatcc gtgttttcga gacatccgtc atcaatcatt ggctttgcgc 1005121 ctccaggata atattcttct gcatgctggt ggatcatcac aaatgttccc ttcagttcat 1005181 gtctgttttg gtgaaggacc ttggccactg cgagaagagc tgcggtgtgg ccgtcgtggc 1005241 cgcatgcatg catgacacca ggcactttgg aggcgtaagg gacatctttt tcatcttgaa 1005301 tggggagagc gtcaaagtcg gccctcaaag cgactgtagg gccgggttcg cttccttcta 1005361 tatttgctaa aacccctcta ccgccaacgt ttgtgcggat tgggactcct aacgattcat 1005421 aataggaagc aataaatgcg gcggtttttt cttcttgaaa tgagagctca ggatacatat 1005481 gaaaatggcg cctgatctca accatttctt caaaacagcc gtcgagctgt ttgtttatct 1005541 ctttctgcag tgtggatatg gacaaagccg cttccccctt ttctatgctt ttccatgatt 1005601 gtatagaaaa agtctgaata tttcaactca tgctgtttta aagcatcatc acagctgcga 1005661 gggttgtcac caaaaggcca atcgcgacgg gaatgaagtt ttttctggca agctcaaaag 1005721 gatcaacttt gcaaatggcc gcggcgggaa tcaaagccca tgggaccagt gttcctccgc 1005781 ccacccagat ggcagagatt tgtccgagcg cggtcagaat agcgggatcg gcatggagag 1005841 cggacgaaaa gagctttgcg atggagccgg cgagagaaat gccagaaaat cctgagccgt 1005901 caaggcctgt tatggctcca gcggcagtta atgcagtggc ggcaagctcc tttgacatag 1005961 gcatcatatg ggataaagca atgccaagat cgttgacaat gccgtgggaa cctttaggga 1006021 gtgaagtgcc cagtatgctt tcatagcctg agtcgccaag ataaaagaaa gcggcaatcg 1006081 ggatgacggg gccgaaaacc ttaaaaccga acttaaatcc gtcaataaaa tagccggtga 1006141 ttttttcaag ccctttatgc ttatacacga aaaaatgaac ggtaaagagg atacaaattg 1006201 cagacccgcc aattaacgcg gttgcatcat ttccttgtag gttaaacaag agcatgcagg 1006261 cgatatctgc aagaaaggca agcggaatca aaaaagccag tatggaccgc aggcgttttg 1006321 gcaagtacag cgagttgtct tgttcgccgg aaagaacggg ggaaaaagaa gtgggatgct 1006381 cctgtttttt gcgttcgcgc tgaatcatga taaaggcagc agttgttgtt gtcacaccca 1006441 taatcagcac aagcggaata ctggccgaga cgacatcacc gactggaatg cctgctgcat 1006501 ccgcagtcag ctttggcgcc gcctgaatga caaagtctcc tgacagggca aaaccgtgtc 1006561 cgaataagtt catggccatg gccgcggcaa gaggcgtcaa accggcacgt gcggctgcgg 1006621 ggagcaggac ggcgccgatc aaagcgacac ccggagaagg ccagaagaat agagaaatgg 1006681 cgaacatcag gcctccaatc agccaatagg cagtcacagg ccctctcaca aggcttgcaa 1006741 agggagaaat catcgcttca tttatccctg tttttgttaa caaatcactc attgaaacga 1006801 taaagcaaat gatgaaaatc gtgggcagca gttcgccggc cgcatagata aagctgtgga 1006861 ataaactgct gacagaagct gaaagtgaat ggctggccca tagcgatatg ataaaaatgc 1006921 cgaatagaga aataaatgtc gtgtcttttc tcagcagcat aaataggata attgcaccga 1006981 taaaaaacac atacagaaca tggacaggca aaatcccgac ttccatcatc gatcactcct 1007041 tccgcttaca gattattcat aggcgggcgg aaggtgccgg gacagagggg agggttatga 1007101 tggaagatga acattgatct gtttcagctg ctcaatcaga tgatgcctta atcctctatt 1007161 cgctttttgc agatgttttg ggaagcattc aggagaaaaa atgacgcacc cttcagcaag 1007221 ccagtttttt ctataggcga tgatgctttc cgatggctct atatgagtta tcctcgtgct 1007281 gcatctcgta ctcatcaaat ccgaactgaa aaccgcagca cgggcagatt tcatgagaat 1007341 gattgccttc atgatcatat ggcggttcag ccaatcctta aacccgcaga ctgggcaagt 1007401 atgcttcatt ttgctttcct cccaataaaa taagctgccg gacatgccgg cagctattcg 1007461 acagcgaaat atgtggtgac ataggaaggc cgggagaaga tcgacgttgt gtcaattccg 1007521 gcagatgtat cgcgtttttt gtgggcttct ttgtaagaac cggactgctg ccagtcttga 1007581 aaggcgcttt ccgtttccca caaggtcaga atgacatagg tgtcactgtc aagcggacgg 1007641 agcactcgaa ttgcttcaaa gccaggctcg ttttcgactt ttcccgctct gtttttaaat 1007701 ctgttttcaa acagcggacg cccttcctga gtaacggcaa tattgttcaa tactgcaaaa 1007761 ccgggatgtt tgatctctcc gacttggtca atgacttcat aagcgtgtgg tgcctggaaa 1007821 acggtatctc cgtttgtttc atgaattaaa atggcgtttt cctgcccctg catcaaaagg 1007881 atattttctg agggatgctt ctgtacgatc gtttttaaaa aatcggctgt cccatatgta 1007941 atataaacct tcatatcagc cacctcctgc ttgctagtat atcaaaacaa tggtataagt 1008001 ttctattggc gagtgcttcg aacataattc caaacaattt ttcccatact acctttagaa 1008061 aggcgaggtg agttcatgtt taagataaag aaaaagaaac tttttatacc tatcattatt 1008121 ttagtgttaa ctgcttttct cgctttaata ggatatattt caattatttt tctcggccat 1008181 tatgtcatag atgaaaaaaa gcttattctt catgcttctt caaaaattgt tgatcaaaac 1008241 ggagatgagg ttgcaagcct gtatacagaa aatcgcgagc cggtctcgat caatgagatt 1008301 cctaagcagg tcagagaagc gtttatcgct gttgaggata aaaggttcta tgagcatcac 1008361 ggcattgatg caaaatccgt cggaagggca gtgtaccgcg atatattagc aggcggaaag 1008421 gtggaaggcg gaagcacgat cacccagcag cttgccaaaa atatttttct gacacatgac 1008481 aaaacatttc taagaaaaac aaaagaagtg atcattgcga ttaatcttga acgggattac 1008541 agcaaggaca agctgcttga aatgtattta aaccagcttt acttcggaca cggggtttac 1008601 ggcatacaag cggcgtccca ctattatttt aataaagaag taaaagattt gactgtatct 1008661 gaaggcgctg ttttggccgc tattccgaag gcgccttcta cgtactctcc aattttgcac 1008721 cctgataaaa ataaggagcg gcgtgataca attctaggta tgatgaatga ccaaggctat 1008781 atcagtgcga aagaggctgt caccgcacag ggccggacgc ttggactgca tgtgaagaaa 1008841 cagtcggaaa caccttggtt tgacagctac attgaccttg tgatcaaaga ggcggaagac 1008901 aagtattcca tttccggaga gcagcttctt caaggcggat acacgatcaa ggtgccgctc 1008961 gattcgaagc tgcagaagac ggcttaccag gtgatgaaag agggaagcta ttatcccgga 1009021 acagatcaga atgccgaggg aagcgcggtc tttattaata acaagacagg cggtgtagaa 1009081 gcggccatcg gcggaaggga ttacacatcc aaaggatata accgtgtcac agctgtccgc 1009141 cagccgggtt ccacatttaa gccgcttgct gtatacggac cggcgatgca ggaaaagaaa 1009201 tttaagccat attctctatt gaaggatgag ttgcagtcct acggagatta tacgccgaaa 1009261 aactacgaca gccggtatga gggcgaagtc actatgtctg acgccattac gtacagcaaa 1009321 aacgcgccgg ctgtctggac gctgaatgag atcggcgtcg aaacagggaa atcttatttg 1009381 aaagcaaacg gcattgatat ccctgatgaa ggccttgctc ttgctctagg cggcttggaa 1009441 aaaggcgttt caccgctcca gcttgccggc gcgtttcata catttgccgc gaatggaacg 1009501 tatactgaac ccttctttat ctcgagcata atagatgaag acggagaaac aatagccgat 1009561 cataaagaag aaggaaagcg ggtattcagc aagcagacgt cttggaatat gacgagaatg 1009621 ctgcagcagg tagtcaaaaa gggaacggcc acgtccggca cctatcacgg cgacctggcg 1009681 ggaaaaacag gttcaacatc ttatacaggc gtctccggcg cgacaaagga cgcctggttt 1009741 gcaggctata cgccgaaaat aaccggggca gtctggatgg gctatgacaa aacggatcaa 1009801 aaccattatt tgaaagccgg gagctcatac ccgacgcggc tgtttaagga tattttgaca 1009861 caggcaggag aaaccggtca tgtgttcaca aagcctaaaa acgttaaaga actggaaagc 1009921 ccgattgagc tgaagccggt caaaacactc acagccgatt acacatttaa agcagcgggg 1009981 ctctttacta ttgaattaaa gtgggacgct caagaggatg atcgggccgt atacagaatt 1010041 tatgtaaaca aggacggcga ggagacgctt cttgattcgg ttgaagggaa gggaagctat 1010101 gaaattcctt atgccaactt attttcgggc gcgtcttata aaattgtgcc ttataataca 1010161 cagacaaaaa gagaagggga aggaaccgat tacgttcagc caaaattgtt ttcctcttaa 1010221 tggaattcgg cgattttttg aactttgagc tacatttcta taccatttgc ctaaaacaag 1010281 gtatagtgta ataagtcaag aaatacgaac gtatggttgc cgtatgaaag gtggaaatca 1010341 gatgagtaaa cgagaaacgt ttaacgagac gtttttaaaa gctgcgcggg gagaaaaagc 1010401 ggatcacacg cctgtgtggt atatgaggca agcagggcgc tcacagccgg aataccgcaa 1010461 gctgaaggaa aagtacggat tgtttgagat cacacatcag cccgaacttt gtgcgtatgt 1010521 cacaagactg ccggttgagc aatacggagt cgatgctgca atcctttata aagatatcat 1010581 gacgccgctg ccgtcaatcg gtgtggatgt tgaaatcaaa aacgggatcg gtcctgtgat 1010641 tgatcagcca atccggtctc tggcggacat tgaaaaactc ggccagattg atccggaaca 1010701 ggacgtgccg tacgtgcttg agacgattaa actgcttgtc aatgagcagc tgaacgtccc 1010761 gctcatcggt ttctcaggtg cgccttttac gcttgcaagc tatatgatcg aaggcggccc 1010821 gtcgaaaaac tacaataaaa caaaagcctt catgtacagc atgccagatg catggaatct 1010881 gctgatgtcc aagcttgccg acatgatcat cgtgtacgtg aaagcgcaga ttgaggcagg 1010941 cgcaaaagcg attcaaatct ttgattcgtg ggtcggcgca ttgaatcagg cagattacag 1011001 aacatacatc aaacccgtga tgaaccggat cttttcagag ctcgcaaagg agaatgtgcc 1011061 gctgatcatg tttggcgttg gcgcaagcca tcttgcaggt gattggcatg accttcctct 1011121 cgatgttgtc gggcttgact ggagactcgg cattgatgaa gccagatcaa aaggaattac 1011181 taaaacagtg cagggcaacc tggacccgtc cattttgctt gcgccatggg aagtcattga 1011241 gcagaaaacg aaggaaatac ttgatcaggg tatggagtca gacggcttca ttttcaatct 1011301 tggccatggg gtatttcctg atgtcagtcc cgaggttttg aaaaaactga cagcatttgt 1011361 ccatgaatat tcacaaaaca aaaaaatggg tcaatattcc taagcatatc ttttggtatc 1011421 ttaatgatat cctgtcaaaa tgtttgtatc agatcattaa agagggtgta aacagtgagt 1011481 agaaagaaaa tggggcttct cgtgatggcg tacggcacgc cttataagga agaagatatt 1011541 gaacgttatt atacacatat cagaagaggc agaaagcctg aacctgaaat gcttcaagat 1011601 ttgaaagaca gatacgaagc gattggcggc atttcaccgc ttgcccaaat cacagaacag 1011661 caggcgcata atctggaaca gcacttgaat gaaattcagg atgagattac gtttaaagcg 1011721 tatatcggac tgaagcatat cgagccgttt attgaagacg ccgtagcaga gatgcataag 1011781 gatggcatta cagaagcagt cagcatcgtg ctggcgccgc atttctccac gttcagcgtt 1011841 cagtcctaca acaaacgcgc caaagaagag gctgaaaaac tcggcggctt aacgattacg 1011901 tcagttgaaa gctggtacga tgaaccgaag ttcgtgacat attgggttga ccgagtgaag 1011961 gaaacatatg cgtcaatgcc tgaggatgaa agagaaaacg caatgctcat cgtatccgca 1012021 cacagcctgc cggaaaaaat caaagaattt ggagacccgt acccggacca gcttcatgaa 1012081 tcggcgaaat taattgctga aggcgcaggc gtttccgaat atgctgtcgg ctggcaaagt 1012141 gaagggaaca cgcctgatcc ttggctcgga cccgatgttc aggatttaac acgtgattta 1012201 ttcgaacaaa aaggctatca agcatttgta tatgttcctg ttgggtttgt cgcggatcac 1012261 ttagaagtgc tttatgataa tgattatgaa tgcaaagtgg ttactgacga tatcggcgca 1012321 agctattacc ggccggaaat gccaaatgcc aagcctgaat ttattgatgc tttggcaaca 1012381 gtcgtattaa aaaaattagg acgttaaaga aggcgatgaa catgagtgac ggcaaaaaac 1012441 atgtagtcat catcggcggc ggcattaccg gtttagccgc cgccttctat atggaaaaag 1012501 aaatcaaaga aaagaatctg ccgcttgagc tgacacttgt tgaggcaagt ccgagagtcg 1012561 gcgggaaaat ccagactgtc aagaaagacg gctatatcat cgaaagaggg ccagactcat 1012621 ttctggaacg aaagaaaagc gccccgcagc ttgttaaaga cttaggtctt gagcatttgc 1012681 ttgtcaacaa tgcgaccggg caatcctatg tgcttgtaaa ccgcaccctg catccaatgc 1012741 cgaagggcgc tgtaatgggg ataccgacaa aaattgcgcc gtttgtttct acgggtctgt 1012801 tttccttgtc cgggaaggcg agagctgcta tggatttcat cctgcctgca agcaaaacaa 1012861 aggatgatca gtcattggga gaattcttcc gcagacgtgt cggagatgaa gtggtcgaga 1012921 acttaatcga gccgctacta tcagggatct acgcaggcga cattgacaag ctcagcctga 1012981 tgtcgacatt tccgcaattt tatcagacgg aacaaaagca tagaagcctg attctcggca 1013041 tgaaaaaaac aaggcctcaa ggctcaggcc agcagctgac ggcaaaaaaa caagggcagt 1013101 tccaaactct gtcaaccggt ttgcagaccc ttgtagaaga gatcgaaaag cagttaaagc 1013161 tgacgaaggt gtataaaggc acaaaagtga ccaaacttag ccatagcggc tcttgctatt 1013221 cgctcgaact ggataacggc gtcacacttg atgctgattc agtaattgtg actgctccgc 1013281 ataaagcggc tgcgggaatg ctttctgagc ttcctgccat ttctcatttg aaaaatatgc 1013341 actccacatc cgtggcaaac gtcgctttag gtttccctga aggctccgtc caaatggagc 1013401 atgagggcac gggttttgtc atttcaagaa acagtgactt tgcgatcaca gcctgtacgt 1013461 ggacgaataa aaaatggccg cacgcagcgc cggaaggcaa aacgctgctt cgggcatatg 1013521 tcggaaaagc cggagacgaa tccattgtcg atctatcaga taatgacatt atcaacattg 1013581 tgttagaaga cttaaagaaa gtcatgaaca taaacggcga gccggaaatg acatgtgtaa 1013641 cccgatggca tgaaagcatg ccgcagtacc atgtcggcca taagcagcgt atcaaggagc 1013701 tgcgtgaagc acttgcatct gcgtatccgg gtgtttatat gacaggcgct tctttcgaag 1013761 gtgtcggcat tcccgactgc attgatcaag gaaaagctgc cgtgtctgac gcgcttacct 1013821 atttattcag ctaaaacctc cgctttatcg cggaggtttt tttgatgtgc aatggcaata 1013881 ttgtgtaaaa aatgattgaa ttgaacagca ggttatgata catttgcata tgtacttaat 1013941 gactaaaatg ttcaaacggt cagtttcgag gtgaatacaa tgtcaataga tcgaaaaaag 1014001 ctcattttgg aggcggctac aaagtctttc acgcagttcg ggtataaagc gacgacaatg 1014061 gatcttgtcg caaaacttgc gaacgtgggg aagggaacca tttatacttt tttcaaaaac 1014121 aaagaagagc tgtttgacga gattttcact actttattaa aggaaatgaa gcaaaaagcg 1014181 gatgaagcga tggagccgag ccttccgttc catgaaaatg tgcacagagc gctgtttgcc 1014241 attctggagt tcaggaaaac acatcagctg acgattaaaa ttttccaaga gaatgccgag 1014301 attggtacaa tggcagttca ggaagtgatc cagaaaatgg agcgatccat cctgtcttat 1014361 atcaaaagca agattgaaga cgggatcaaa agcggcgcaa tcaagccgtg cgaccctgag 1014421 ctgacagcct ttgtgatgct gaagctttat atcgcgctca tttttgactg ggaaaaacaa 1014481 caccccccgc ttgataaaga gacaattgcg ggactgcttg aattgtatgt tgtcaaagga 1014541 ttgtcagcga actagataat cctttctctt tgcaagaaaa tgaccatttt ttatgatgag 1014601 tcagttttag aatggaggca tcaggatgaa cacaatacga agtcagtgga aagacatcgt 1014661 aacaagtaaa aaattattga ttcccatcat cgccattttg tttgtcccgc ttatttacag 1014721 cggcgtattc ttaaaggctt attgggaccc gtacggcaca gttgaccagc tgcctgtcgt 1014781 tgtcgtcaac caagacaagg gagcaacgta tgaaggagaa aaacttcaaa tcggtgatga 1014841 tctggtcaaa gaattaaagg ataataacaa ctttgattgg catttttcca atgatctcga 1014901 ccaatcgtta aaggacttat tgaatcaaaa atattattta gttgtcgaga ttcctgagga 1014961 tttttctaag aatgccagca ctgtattaga caaaaatccg aaaaaattgg atctgaaata 1015021 ccatacaaat gcaggttcta actatgtagg ggcaacgatc ggcgaaaaag cgattgataa 1015081 actgaaagcc tctgtttcaa aagaagtgac cgagcaatat acgaaagtta tttttgataa 1015141 ctttaaagat atcgcaaaag gtttgagcga cgcgagcagc ggcgcgaaaa aaattgatga 1015201 cggcacaaag gatgcgaaaa acggaagcgc ccagctgaaa gaaaatctgg cgaagctgaa 1015261 ggaaagcacc gctaccatca gtgacaaaac agcgcagctt gcagatggag cggctcaggt 1015321 gacgagcggc atccaatcac ttgacagctc gctcggtaaa ttccaggaca gcagcaacca 1015381 gatttatgat aaatctagtc agcttgcagc aggatcaggc gagctgacaa gcaagatgaa 1015441 tgaacttctt gccggacttc aaaatgtgca gaagggtacg cctaatctta ctaacgggtt 1015501 ggatcagctc aacagtaaag tccaagaagg ttctgagaaa gcggcaaaag cggaaaagat 1015561 cattaatgcg ctcgatttaa cgaagcttga aactgctgta aacaatctgg aaaagtcaga 1015621 aactgcgatg aaggaattca aaaaacagct gactgacttt gaaaacagtt tgaaaaaccg 1015681 tgatcaggca tttaaaaatg tcatcaattc gagtgacttc ttaacagcgg agcaaaaaag 1015741 ccagctgatt aattctgttg agaaaaagct tccgcaagtt gatgcgcctg attttgatca 1015801 aatattaagc cagctaccta cagctgatca gctgcctgac atcgcaacga taaaaagctc 1015861 tcttgaagac gtgaaagcgc aggtggcgca ggtgaaagcc atgccggaag ctacatctaa 1015921 gctttataac ggcgcaaaaa caatccaaga tgcgattgac agattaactg agggagctga 1015981 taagatatac aacggttctc agaagctgac agatggccaa actaaactga cagcgggcat 1016041 cggtgaatat aataagcagt tcgcaaaagc aaaagcgggc tcagagcaat tggtgacagg 1016101 aagcagccaa gtatccggcg gattgtttaa gctgttagac gggtctaaac aggtccaaag 1016161 cggatcatca aaacttgcag acggatctgc atcacttgat acaggtttag gcaagctatt 1016221 ggacggcaca ggagagctgt ctagtaagct gaaggatgcg gctgaccaaa caggagatat 1016281 cgatgctgat gatcaaacat acggcatgtt tgcggatccg gttaaaacca aagatgatgc 1016341 cattcattcc gttcctaact atggaacagg gctgacacct tatatcctgt caatgggctt 1016401 gtatgtcggc ggcatcatgc tgacggttgt cttcccgctg aaggaagcgt caggacgtcc 1016461 gagaaacggt tttgagtggt tcttcagcaa attcaatgtc atgatgcttg taggaatcat 1016521 tcaatcattg attgtggcga cggttcttct attgggaatt ggtcttgagg tagagagcac 1016581 gtggagattt tacgtgttta cgatcattac gagtctcgct ttcctggcga taattcaatt 1016641 tttggctaca acgatgggca acccggggcg atttatcgca gtcattattt tagtgctgca 1016701 gctgggagcg agcggaggaa ccttcccgct ggaattgctt ccgaatttct atcaggtcat 1016761 ccacggcgca ttgccgatga cctacagcat taacggattc agagcagtca tttcaaacgg 1016821 tgactttggc tacatgtggc agatggccgg cgtcttaatc ggcattgccc tcgtcatgat 1016881 tgcactaagc attacttact ttacaatgtt aagccggaag gaagaaacat cagaagaaca 1016941 gccggcttca taaagaaaaa gaacttgttt ccttggaaac aagttctttt tttgttacat 1017001 cccccattta ataagcaatc ctgtataggt taatccgccg ccaaacccga aaagcaaaac 1017061 gatttgatct tttttcagct tcccggcttt cactgcgaga tcgagcgcca aaacaattga 1017121 aaccgaagac gtgtttccgt agtgctcaac actagtgagc gttttttcaa tcgggaacgg 1017181 tgttttttca caaattgact cgatcatgcg caagttggcg ctgtgaggaa caaaccaatc 1017241 gagatcatcg gagctgagtc ctgctttatg taaaagccgt tcaaattcgc cagggacggt 1017301 tcttgcggcc catttatata cctcgcgtcc gttttgcacc atttttccgg aaccgacaag 1017361 ctgcacaccg tttatttcat ttcgcagtcc ggcacgatac aaaatatcgc cgccgttccc 1017421 gcttgttcct tgtacagacg caagaaatcc cggcgtctct tcatctcgtt ctactaacag 1017481 cgcacccgcg gcatcgccga acagtacgca tgtcgttcga tcggtataat cggttacctt 1017541 tgataacgtc tctccggcga tgacgagaat tttttgatga aggccagatg tgatcaatcc 1017601 atttgccaaa tggaggccgt atgtcagccc ggcgcatgtc gcattaatat ccagcgcgcc 1017661 ggtgctttcc cagccgaaat attcctgtac gcggcatgcc gtactcggaa aggcgtaatc 1017721 ggatgtggtt gtggcaacga ggatcatatc gacatcatca agcgttcctt tataacggct 1017781 cttgagattc ttcaccgctt ctatgcataa atcagaggta aattgatgtt catccgcaat 1017841 ccggcgttct ctcattcctg tgcgctgaac gatccattca tcagaggtat caacgatctt 1017901 ttctaaatct gcattggtta aacgtctgct cggcgcatag gtgccgatag ctgtaatttt 1017961 tgcttttgac atatgaatca ctccttatgg tcagattata acactagata ttagtatctg 1018021 gtactaaaaa gaaggttttt ttacaaaaaa agagaagtgt agataggaat ctatgaaaaa 1018081 gaaaaaggag gctgaaaaat ggtcagtcaa gaagcagtag tctttttggc attatccggg 1018141 gctattgcgt ttctgttgcc aatcgggctg attgtatggt ttaagcgaaa gtatggtgcc 1018201 tcgcttaaag tgttttttat tggcgctctc acgttttttg tcttcgctca gctgctggaa 1018261 ggcggcgttc atgtttatgt actgcaagtg aatgaaatga cgaaagaagc gatgcagcat 1018321 ccattatggt atggcattta cggctgcttg atggccggca tttttgagga gtgcggaagg 1018381 tatttgatga tgcgattttt tatgaagcgc catcatactt gggcagatgg tctggctttc 1018441 ggggcaggcc atggcgggct tgaagccatc ctgattacag gcttgtcctc tatctcactt 1018501 attgtatacg catttgcaat caatagcggg acgtttgaac agcttttggt caatggcgac 1018561 gtcaaacagg cgcttttgcc gatacaggag cagctgctgc atactccttc gtatgaatgg 1018621 atgctgggcg gaatagaaag aatcagtgcc attgccgtcc agattggtct gtctctgctt 1018681 gttttgtacg cggttaaaaa ccgccggccg ctgtttttgc tgtattctat tcttttacat 1018741 gcactgttta atgtcccggc ggttttatat caaagaggaa tcatagagca tgctgcagct 1018801 gttgaaatca ttgttgctct tatagcggct ttatcagttt attggattgt aaaagcaaaa 1018861 agggtgtttc aataaaaggt ccaagcagca gcaatgcccg cttggaaaaa tgtgaatgga 1018921 aatattcatt aagcatgggt catcagaata tttctgattc agtctttagc aatgacagca 1018981 agaatgtctg tgttttttac aagagaaaca atggtgtttc tttttcttct tctcgcaagg 1019041 gtcatggcat tctttctttt tcttgcaatg gtcgtggaaa tctttatcga accactcgtc 1019101 aaagaaccaa aaatcatcga accaatcgtg acaacgacat ttctgttcat gtgaatgacg 1019161 acagcacata gaaatccctc ctcttcccat gctctctaca gcatatgaga gattgatagg 1019221 aaaagattgg acgggtccct cgggaaaaga gtatatttta agtagaaaat aaaaggagga 1019281 atgccctatg acgtccgtac gtaaaacgat ggagctcatt aaagaacttg tatcgatccc 1019341 aagcccgaca ggaaatacat atgaggtgat caattatatt gaaagccttt taaaagaatg 1019401 gaaggtagaa acggttcgga accacaaggg cggcttaatt gcaacgcttc caggacgcga 1019461 cacatcccgg catcgcatgc tgacagcgca cgttgacacc ctcggcgcta tggtgaagga 1019521 aattaaagcg gacggccggc tgaaaatcga cttaatcggc gggttccgct acaactcgat 1019581 tgagggggag tattgccaaa ttgaaaccgc ctcgggaaaa atgtacacag gcacaatctt 1019641 aatgcatcaa acgtctgtgc acgtatacaa agacgcggga aaggctgagc ggaatcaaga 1019701 gaatatggag atccgcctag atgaacctgt tcactgccgg aaagatacgg aggagcttgg 1019761 cattggcgtc ggagactttg tgtcgtttga tccacgtgtc gagatcacat caagcggatt 1019821 tattaaatcg cgccatttgg atgacaaagc aagcgtcgcc ttattgctcc gcttaattca 1019881 tgaaattcaa acagaagaca ttgagctgcc gtatacaacc cattttctta tttccaataa 1019941 tgaagaaatc ggttacggcg ggaattcgaa tattcctcct gaaacagttg aatatttggc 1020001 ggttgatatg ggcgctatcg gtgacgggca ggcgacggat gaatattcag tatcaatctg 1020061 tgtgaaggat gcgagcgggc cgtatcatta tcagctcaga aagcatttag ttcaattagc 1020121 cgagaagcat catattgact ataagcttga tatatatccg tactacgggt ctgatgcgtc 1020181 agcagcgatc aaatccgggc atgatattgt gcatggcctc atagggccgg gaattgacgc 1020241 ttcccatgca tttgaacgca cccataaatc atctcttcgc cataccgcta agcttctgta 1020301 ttactatgta cagtcaccaa tggtataagg gggaggacca atgaagattt ataagctgaa 1020361 aagcacattc ggttgggaag gtgatgacgg gttgggagaa cagctgattc agcagatcct 1020421 tgccggagaa aaaagcgcca cgtgcgcgcc gaaatcattg tattcaaaag atgaattgag 1020481 ggacgtttat caaacagcgg gtcagcttgt taccgtttat gataaacatg acaatccaag 1020541 atgcaatata aaagtaacag atgtctttga aaccaccttt ggtgcgcctg atatgaggtt 1020601 agtcaaagga gagggcaatg gagaccgaat tgaggagttt caagaggatc atcggatggc 1020661 atgggcggaa ctgatcaaaa gcggtgaact ggagctgaat gaggatactg ttttgattac 1020721 agagttgttt gtgcttgtta aagattaaaa aagcctgcgg ggcaagaacc ccgcaggctt 1020781 ttcattaacc agaaatggtt gcgttttgtt ctgttttcga ttgggacata acagtttctg 1020841 ctttcgcagg attaaacatg ccttcccatt tagacatcac aacggcagca agcgcgttac 1020901 cagtcaggtt gacaactgta cgtgccatat ccatgatgcg gtctacgccg gcaataaagg 1020961 caagtccttc agccggaacg ccgatggtgc caagcgttgc aagcaagaca acaaaagaag 1021021 taccaggtac ggcagccatc cctttggatg tcaccattaa gacgagcaca agcgtaattt 1021081 ggtgccaaat cgtcaaatca atgccatata cctgtgctaa aaagagtgcg gcaatagatt 1021141 gatagagaac ggaaccgtct aagttaaacg tgtaaccgat cggaatgaca aatgaaacaa 1021201 tgccttttgg acatccgatt ttctccattt tttccatgat acgcggaaga accgtttcag 1021261 agctggacgt actgaacgcc agtaagattt cgtccttcat gtaagcaagg aacttgaaga 1021321 tgctgatgcc ggcaattttt gcgacaatcc cgaaaataac aattaagaag aaagcaagcg 1021381 cgacataaac caatccgacg agctttccga gagagataag agaaccgagt ccgaatttag 1021441 acacagtcac tccgataaga gcgaaaacgc cgaatggcgc cactttcatc acaaggttta 1021501 caacgtggaa catggcatgg gatacacctt caaaaaaggc taatacaggc ttgcctcttt 1021561 caccgatcgc ggaaataccc aatgcaaata gtactgtaaa gcagatgatg gctagaagat 1021621 ccccttcgac caatgactgg aagaagtttg tcggcacaat atggaggaac gtttccgcca 1021681 ctgatttatt actttgttct ttttcagttt caacatattg actgatgtcc gatttttgag 1021741 cttcgtgtat attaactcct gtacccggat ggaagatgtt tgcaagggct agtccgagaa 1021801 taatggcaaa agtcgtgatg atctcgaagt acagaatcgt tctgaagcct aatttaccga 1021861 cttgctttcc atttcctgca ccggctacac cgatgattaa gctggagaca acaataggaa 1021921 tcactatcat tttgattaag cgtaaaaaga gatccccgat tggctgcagg taagtaggca 1021981 atgctgggtt gccataccaa atgacgccaa caatgacacc tagaataagt ccaacgaata 1022041 tttgtgtggc taatccaaac ttaattcttt tcatagatta cctcccaaaa aacaaagtat 1022101 caacatatat catgaataga catatattta atctcactat tagatcaaat tataatagat 1022161 aagaaatcaa ttcgtctata gtaaattata tttcgaaaat aaagaatatt caatgacatt 1022221 atgataatca ccagaattat ctaaaaacag gtgagctttg acctaacctg actattattt 1022281 caaaattaag agatatgtga aaaaataaga aaatcccacg cgtaaggcgc gggattttcg 1022341 ctcattacaa atcgtttact tttatacagt cattgcagat attaccataa cactcatgct 1022401 gctcttctat cttttttccg cattccgcac actttttcga aggcaggttt ctaaaaaatt 1022461 ctgtgatttt ccccagcata accaatccct ctttcccctt tgtagtgatt tcattgtaat 1022521 ataacagatt acaaaaatca ataactgttt tgatacaatg tttaaaacat gcttttttca 1022581 agaaaaatgg gtatattgaa ggaggaccaa tttttttgaa aagataggag gacattatga 1022641 aagttacagt tatcggatgc tatggcggtt ttccggccgc aaatgaagcg acgtcaggct 1022701 atttgtttca gtcaggtgat tactctctgc ttgttgattg cggcagtgcc gtattgtcta 1022761 agctgttcgg atatgtgccg gcggaaaagc tggatgcggt cgttctgtct cattatcacc 1022821 atgaccatat cgctgatatc ggaccgctgc aatttgccaa gcaagtcggt tcgtttctcg 1022881 gcaaaggaga gcatacgctt ccgatttacg gacatgatgc tgatatagaa cagtttcaaa 1022941 agcttacata taaaacacat acaaaaggga tcgcctatca gccggatcag ccgctgactg 1023001 ccggtccgtt tacgatcacc tttttaaaaa cgattcaccc ggtgacgtgc tatgccatgc 1023061 ggattactga cggcagccac actgtcgttt atactgctga ttccagctat caggattcat 1023121 ttataccgtt ttcgaaagat gctgatttat tgatctcaga atgcaatttt tatgccgatc 1023181 aagacggaac aagtgcaggc catatgaaca gcctggaagc tgggcgcatt gcaaaagaag 1023241 ccggagcggg agaactgctg ctgacacatt tgccgcattt tggcgtgcat gacaaccttc 1023301 gcaaagaagc gaaaaccgtt tttaacggag aagtgaatat tgcgaaatca ggttttgtgt 1023361 gggaaggata aaggaggagc accatgttat ttatagacaa tcaaaatatc aatgatccgc 1023421 ggatcaatct tgctatcgag gagtactgtg taaagcattt agaccctgaa cagcaatatt 1023481 tgctctttta tgtgaatcaa ccgtctatta tcattgggaa aaaccaaaat acaatagaag 1023541 aaatcaatac aaaatatgtt gaggaaaacg ggattatcgt cgtccgccgt ttatcaggcg 1023601 ggggcgctgt gtaccatgat ctggggaact tgaacttcag ctttattacc aaggatgacg 1023661 gggacagctt tcataacttt aaaaaattca ctgagccagt gattcaggcg ttacatcagc 1023721 ttggggttga agccgaatta agcggccgga acgacattgt agtagatggc cggaaaatat 1023781 ccggaaacgc tcagtttgca acgaaaggcc gtattttcag ccacggcacc ctcatgtttg 1023841 attcagccat tgatcatgtt gtatcagcat taaaggtgaa aaaggataaa attgaatcaa 1023901 aaggcatcaa atcgatcaga agccgagtgg caaacatcag tgagtttctc gatgataaaa 1023961 tgaccaccga agaattccgc agccatttgc ttcgccatat ttttaacaca aacgacgttg 1024021 gaaacgtgcc ggagtataag ctgacggaaa aagattggga gaccattcat caaatttcga 1024081 aagagcgcta tcagaattgg gattggaact acggccgctc accaaaattt aaccttaatc 1024141 attcgaagcg ttatccggtt ggatcgatcg atttgcacct ggaagtcaag aaaggcaaaa 1024201 tcgaggactg caaaatcttc ggagatttct tcggtgtcgg tgatgtatct gaaattgaaa 1024261 acctgctggt cggaaaacaa tacgaacgca gcgtcatcgc tgatgtgctc gaaggtgtga 1024321 atctcaagca ttactttggg aacattacga aagaggattt ccttgatctg atttactaag 1024381 gcaaaacaca tcgtttgaaa gagcggttgt gtttttgaaa taatggaggc aggagggatt 1024441 cacatgaaag tgtttttaat cggagcgaac ggacaaatcg ggcaaagact cgtctcttta 1024501 ttccaagata atcctgatca ttccatcaga gcgatggtca gaaaagaaga acagaaagcg 1024561 tctcttgaag ctgccggtgc agaagctgtg cttgcgaatc tggagggcag cccggaagaa 1024621 atcgccgctg cggcaaaagg ttgtgacgcg atcattttca cagccggttc cggcggcagc 1024681 acaggctatg ataaaacgct gctggtggat cttgatggag cggcaaaagc cattgaagct 1024741 gcggccattg ccggaatcaa acggtttatt atggtcagcg ccctgcaagc ccataaccgt 1024801 gaaaattgga atgaggcact caagccttat tatgtggcca agcattatgc tgataaaatt 1024861 ctggaagcga gcggtttaac ctatacgatt atccgtccgg gaggccttcg caatgagcct 1024921 ggaacgggaa ctgtttcagc agcgaaggat ctggagcggg gatttatttc ccgtgatgac 1024981 gttgcaaaaa cggtcattgc ctctttagat gagaagaata cggaaaatcg ggcctttgat 1025041 ctgacagaag gagatacgcc gattgccgaa gcattgaaga aactatgaca gtactgacac 1025101 tcagggcttt ttgctcttga gtgttttttt ctgtttctct ataatggaga agaaagcttg 1025161 gcttcaataa tgaatgacta ttcattcact taaggggtgg gagaatgaat cttgtttcaa 1025221 aattggaaga aacagcatct gagaagcccg acagcatcgc atgcaggttt aaagatcaca 1025281 tgatgacgta tcaagagctg aatgaatata ttcagcgatt tgcggacggc cttcaggaag 1025341 ccggtatgga gaaaggggac catttagctt tgctgcttgg caattcgcct gattttatca 1025401 tcgcgttttt tggcgcttta aaagctggga tcgtagttgt tcccatcaat ccgttgtaca 1025461 cgccgacaga aattggttat atgctgacaa atggcgatgt aaaggcaatc gtgggcgtta 1025521 gccagctttt gccgctttat gagagcatgc atgaatcgct gccaaaggtt gagctcgtca 1025581 ttttatgcca gacgggggag gccgagccgg aagctgcgga cccagaggtc aggatgaaaa 1025641 tgacaacgtt tgcaaaaata ttgcggccga catctgccgc taaacaaaac caagaacctg 1025701 tacctgatga taccgcggtt attttatata cgtcaggaac gactggaaaa ccgaaaggcg 1025761 cgatgctgac acatcagaat ttgtacagca atgccaacga tgtcgcaggc tatttgggaa 1025821 tggatgagag ggacaatgtg gtctgcgctc ttcccatgtt tcacgtgttt tgtttaaccg 1025881 tctgtatgaa tgcaccgctg atgagcggcg caactgtatt gattgagcct caattcagtc 1025941 cggcatctgt ttttaagctt gttaagcagc agcaggcgac catttttgcc ggtgtgccta 1026001 caatgtataa ctacttgttt cagcatgaaa acggaaagaa agatgatttt tcttcgatcc 1026061 ggctgtgcat ttcgggaggc gcgtccatgc cagtcgcgtt gctgacggcg tttgaagaaa 1026121 aattcggtgt taccattttg gaaggctacg ggctctcgga agcatcaccc gtcacgtgct 1026181 ttaacccgtt tgacaggggc agaaagccgg gctccatcgg gacaagtatc ttacatgtcg 1026241 aaaacaaggt cgtagatccg ctcggacgcg agctgcccgc tcaccaggtc ggcgaattga 1026301 tcgtgaaagg ccccaatgtg atgaagggct attataaaat gccgatggaa acagagcatg 1026361 cattaaaaga cgggtggctt tatacggggg acttggcaag acgggatgag gacggctatt 1026421 tttacattgt tgaccggaaa aaagacatga tcattgtagg aggatacaat gtgtatccgc 1026481 gggaggtgga ggaggtgctg tacagccatc cggacgtcaa ggaggcggtt gtcatcggcg 1026541 tgccggaccc ccaaagcggg gaagcggtaa agggatatgt ggtgccgaaa cgctctgggg 1026601 taacagagga ggacatcatg cagcactgcg aaaagcatct ggcaaaatac aagcggcctg 1026661 ccgccattac gtttcttgac gatattccga aaaatgcgac ggggaaaatg ctcagacggg 1026721 cactgagaga tattttgccc caataaaatg aaaaagcgaa gcggttagct tcgctttttc 1026781 attttcaatc ctttgcttct tttttaataa tatttagcag cgcctttgta tcatttttgc 1026841 ttaatttgta gtatgtgcca tccttcaaaa aaacggcttg ctggctgccg tcaatccata 1026901 gtctgaatga gtcataccgg tctttatgaa acttgattgt cccttcgtaa tcaggggctg 1026961 atgttttttc tgtcttcacc tgttttccct gattcataat atccagcata tctttgacgt 1027021 gctgtctttt ttcaatctcg atatcttcct ggccgcttga agacagtgtg atcaaatccg 1027081 cgtctaccga ttgatacaca tcgcctgatc ggctgtaaag ataaaaaaat gcgataaaca 1027141 caagaccgat taccacgatg gctgccacta tttttttcat ttgcatcact ccaaacattg 1027201 ttagttttcc cagcgatcgg ggtttccatg cttaaaaggg tggaaaagtg cggaacacag 1027261 cttggttcta agaatttgaa tttatgatta caatagaagt aacgggttga tgtgaggagt 1027321 gaggcgttat gcgcaagtgg attgcggcag caggacttgc ttacgtgctg tacgggctgt 1027381 ttttttattg gtattttttc ctgtcgggtg attccgcaat accggaagcc gtgaaaggga 1027441 cgcaggctga tccggcttct ttcatgaagc cgtctgagtt ggcagtggcc gagcagtatt 1027501 cgaatgtcaa gaatttttta ttttttatcg gggtaccact tgattggttt ctgttttttg 1027561 ttctgcttgt cagcggtgtt tcaaagaaaa tcaagaaatg gatcgaagcg gccgtgcctt 1027621 ttcggttttt gcagaccgtt ggttttgtgt ttgtgctttc gctgattaca acattggtga 1027681 cgctgccttt agattggata ggctatcaag tatcgcttga ctataacatt tccacacaga 1027741 caacggccag ctgggctaag gatcaggtta tcagcttttg gatcagcttt ccaatcttta 1027801 cgctttgcgt tctcgttttt tattggctga tcaaaaggca tgaaaaaaaa tggtggttat 1027861 acgcctggct gttaacagtg ccgttttcgc tgtttctgtt ttttattcag ccggtcatta 1027921 tcgatccttt atacaatgat ttttatccgc tgaaaaacaa agagcttgaa agcaaaattt 1027981 tagagctggc agatgaagcc aatattccgg ctgaccatgt atatgaagtg aacatgtcag 1028041 aaaaaacaaa tgcgctgaat gcctatgtta caggaattgg ggccaataaa cggattgtat 1028101 tgtgggatac gacgctgaac aaacttgacg attcagaaat tctgtttatt atgggccacg 1028161 aaatgggcca ttatgtcatg aagcacgttt acatcggtct ggctggctat ttgctcgtgt 1028221 cgctcgccgg attttatgtc attgataagc tttacaagcg gacggttcgc ctaacccgca 1028281 gcatgtttca tttagaaggg cggcatgatc ttgcggcact tccgctgtta ttgcttttgt 1028341 tttctgtttt gagctttgcg gttacgcctt tttctaatgc tgtctcgcgt tatcaggaga 1028401 ataaggctga ccagtatggg atcgagttga cagagaacag agaagccgct gttaaaacgt 1028461 ttcaggattt ggccgtgacg gggctgagcc aggttgatcc tccggtgctt gtgaagattt 1028521 tcagaggcag ccatccgtcg atcatggaac ggattcaaca tgcggagaaa gaagagaatg 1028581 cgccggaaca tcaggatgct gacaaataaa aagaagcagg tatggaggaa cctgcttctt 1028641 tttactatta ttgtgcagct gcttgtacgt tgattaaccc ttttccatag tagaaagagt 1028701 ttccaagata tgttgcagtg ctttctaaac gatcacggac ttgcgcgttt gtccaagtcg 1028761 ggtgcttaga aagaattaac gctgctgctc cggcaacgtg aggagtcgcc atggacgttc 1028821 cgttataagc gccgtaagtg cctccaggaa gtgtgctttg gatggacacg ccaggagcca 1028881 tcacatcaag ctcagaacct gcgctggaga atgaagctct ttggttgctg ctgtttaccg 1028941 cacctactgc aatagtagaa ggatattttg cagggtagcc gactgtgctt gtgcttccgg 1029001 atgaaccttc gtttccggct gcggcagcaa cgacgatacc gctggaaacg gctttgtcaa 1029061 cgactgtttt cagcgctgta gaaccagtag gtccgccaag gctcatgttg ataacatcca 1029121 tattgttgga aatggcccac tcaatgccgt taataatcca gctatattgg ccgcttcctg 1029181 ttgaatcaag cacttttact gcatataatg atgcgcttgg cgctacgccc agaacaccga 1029241 ttgagttatt aagagcggca atcgtaccgg ctacatgcgt accgtgagaa ctgccgtcct 1029301 ggtatgggtt tgtttcagaa ggtacgaagc ttgctccgcc tctgacgttt aagtcaggat 1029361 gagaagagtc aattccgctg tcgataacag ctacttttac gttagagcct gtgtagcctt 1029421 gagagtgaag agccggcgct ttaatttgag aaatgccata aggaacagat tgcgcatatt 1029481 catgtgcaat atgatcttct tccacatatg caacgctcgg atcttttttc aattctttta 1029541 cagctttttc atccaatgtt gctgcggccg cgttaacata cttaaattgc ttttgaacct 1029601 ttccgccttt ttcagaaata acatcctttt tcttggcgga actcatggca ctcattgtct 1029661 gtttaaatcc gacaatgtat ttcttttctg tactgctttt tccggcagcc tgcgcagaca 1029721 tgttgctgaa cgccatcgta aagattaacg ttaacgcaaa caacaagctg atccacaatt 1029781 ttttgcttct cactctttac cctctccttt taaaaaaatt cagagtagac ttacttaaaa 1029841 gactattctg tgaatttatt gtaatagatg gaataatatt ttagtagacc catttttttg 1029901 agatgatttt atctctattt aggtatatca tctctcgcta tttccgtaga gactcgaaat 1029961 aactattttc atacagaaaa gaacgaaaat agacatgagt aaatgttcat tatgctgaaa 1030021 tgtcatgctt ttttaggtta aatgctcctg agtcccggca aattcctgtc gaaaaaattc 1030081 gttcaaatga cctgcgtgtg cttccgtgag aacaatggat attatcgtga tattttttca 1030141 aagcatgatg ataaaagtat tctgaaaaat aaactttaca gaaaagggat agaatgaaaa 1030201 aattattgag agggaggaag aaataagatg aacattcgcc aagcaaagac atcagatgcg 1030261 gccgccattg cgccgctgtt taaccaatat cgggaatttt atagacaggc atccgatttg 1030321 caaggggcag aggctttttt gaaagctcgt ttggaaaatc acgagtctgt tattttgata 1030381 gcagaagaaa atggagaatt cataggcttt acccagctct atccaacgtt ttcttctgtg 1030441 tcaatgaaaa ggatatacat attaaatgac ttatttgtcg ttcctcatgc gcgtacaaag 1030501 ggagccggcg gccggctgct ttctgccgca aaggattatg cagggcaaaa cggggcaaaa 1030561 tgtttaacac ttcagactga gcaccacaac cggaaggcaa gaagcttgta tgagcaaaac 1030621 ggctatgaag aggataccgg atttgtccat tattgtctca atgtgccggc gaagtgaaaa 1030681 tggcggcttg atgatttggt tttttgaacg ttcttcggtt acgatataaa tgaaaaggag 1030741 tgtgccgaat gtcaacgtta tttcaagcct tgcaggcaga aaaaaatgcc gatgatgttt 1030801 cagtccatgt gaaaaccata tcaacagagg atttgccgaa ggatggtgtc ctgattaaag 1030861 ttgcttattc cggcattaat tacaaagatg gtctggccgg aaaagcagga ggcaatatcg 1030921 tcagagagta tccgcttatt ttaggcattg atgctgcggg tacggtcgtc tcttccaatg 1030981 atccgcgttt tgcggagggg gatgaggtga tcgcgacaag ctatgagctc ggtgtctcac 1031041 gtgatggcgg attaagtgaa tacgcttcgg tgcctggtga ctggctggtg cctttgccac 1031101 agaatctttc gttaaaagaa gcgatggtgt acggaacggc gggatttact gcggcgttat 1031161 cagtgcatcg gcttgaacag aacggtctgt ctccggaaaa aggcagcgtg ctagtcacag 1031221 gagcaaccgg cggtgtcggc ggaattgcgg tatcgatgct gaacaagcgg ggttatgatg 1031281 tggtggcaag taccggaaac cgggaggcgg ctgattattt gaaacagctt ggtgcaagcg 1031341 aagtaatcag cagggaagat gtctatgacg gaacgcttaa ggcgctgtcc aagcagcaat 1031401 ggcagggagc ggttgatcca gtcggcggaa aacagcttgc ctcgctttta agcaaaattc 1031461 aatacggcgg atctgtcgca gtgagcggct taaccggcgg aggagaagtt ccggcaaccg 1031521 tgtatccttt tattcttcgc ggagtaagcc tgctcggaat cgattcagta tattgtccga 1031581 tggacgtcag agccgctgtt tgggagcgca tgtcttctga tctcaagcct gatcagctgc 1031641 tgaccatcgt ggacagggaa gtatcattgg aagaaacgcc gggtgcgtta aaagatattt 1031701 tgcaaaatcg cattcaagga agagtgattg tgaagcttta acaggatcag cttgcagaga 1031761 atgttatttt tctgcaagct tttttgtgga caggatgatc agctgctgaa ctgctgtgtc 1031821 gcgaaacaag attttcctgt aagccgaact ttctcttctc attttaaaaa taattggtga 1031881 taatgattct cattccgtgt tatactactc ttggacatct taaccataga aactaccaac 1031941 aggagagact ggaacatatg aaaaaaacac tgattattct tacagtttta cttctttctg 1032001 tcttaacggc tgcttgctcg tcttcaagcg gcaatcaaaa cagtaaagaa cataaagtgg 1032061 cggtaacaca tgatttaggg aagacaaatg tgcctgagca tccgaagcgg gttgttgttc 1032121 ttgagctagg ttttattgat acactgcttg atctcggcat tacgcctgtc ggggttgccg 1032181 atgacaacaa agcgaagcag ctgatcaaca aggatgtgct gaagaaaatt gacggctaca 1032241 catctgtcgg cactcgctca cagccaagca tggaaaaaat cgcttcatta aaacccgatt 1032301 taattattgc tgacacgacc cggcataaga aggtgtacga tcagctgaaa aaaatagcgc 1032361 cgacgattgc acttaataat ttaaatgctg attatcagga tacaattgac gcttcgctta 1032421 cgattgcaaa agcagtcggc aaggagaagg aaatggagaa aaagctgacg gcgcatgaag 1032481 aaaagcttag cgagacaaag cagaaaatca gcgcgaacag ccagtccgtg cttttgatcg 1032541 gaaatacaaa tgataccatt atggccaggg atgaaaactt ctttacatcg agacttttaa 1032601 cacaggtcgg ctaccgatat gcaatcagta cgtcaggcaa tagcgattca agcaatggcg 1032661 gcgactctgt gaatatgaaa atgacactgg agcagctgct gaaaacagat ccggatgtga 1032721 tcatcctgat gacaggaaaa acagatgacc tcgacgccga cggtaaacgc ccgatcgaaa 1032781 agaatgtcct ttggaaaaaa ctgaaggcag tgaaaaacgg gcatgtatac cacgtggatc 1032841 gtgcggtgtg gtctctgcgc cgcagtgtag acggggcgaa tgccattttg gacgagcttc 1032901 aaaaagagat gccggctgct aagaaataaa agaaaagaca ggcaaacgcc tgtctttttc 1032961 ttatttgata aagccggata agtggctgtt gatattatag tcttttatcc gccatttttc 1033021 ttctgcaaat tcaatgttgc tgaggcaggc gttgacgaga cgggtgcttt gaagctccgg 1033081 gtcaccgccg gatatttctg tcagcagggc gtgaattgcc gcaccgtgcg ccacgatcag 1033141 caccttcttg tttggatacg cctgattcac ttttgccaaa ccgcccatca gcctgtcagt 1033201 gagttcttct aaggtttcca tattcggata gatgttatct ggatagcgct ttgtccgttc 1033261 ctccagcggc atgccctccg cgtcgccgta atcgcgttcc ttaaaatcat ccatctcgac 1033321 tatcggaaga tgcagatatt cattaataat ttccgcggtt cttttcgctc ttttcagcgg 1033381 gctcgtcaca ataatatccc aagaaaagtc ctttacatat tctccggttt ctcttgcttg 1033441 gcgttcacct gttgcgttta gcgggatatc ggttttgcct tggcattttt gctgcaggtt 1033501 ccaatcggtt tctccatgtc ttactaaaca aacggctgtc ataaaatccc cttcctgact 1033561 ttattcatat cgctattata ctaaatcgaa agcgtgtgtc ctatgaaaaa gcctatgcaa 1033621 gaacttcaaa taataaagcc agtccgattc cgccgccgct tccgatggct gcaacagcat 1033681 attgacagtc tggccgtctt ttcgcttcat aaaacaatct ggttaccaga gctgcacctg 1033741 atgcaccgta cggatggcca agagctaagg cgccgccgcg cacattgatt tttgaaaagg 1033801 gaatgccgag ttcttgcgag cagacacaaa ttttgacggc aaaggcttca ttgatttcaa 1033861 ataaatcgat atcatcaggt gttacatcgt gtgtatgtaa gagctgacga atcgcgacaa 1033921 ccggtgccgc gggcggaaag ttggggtgaa tgccgctgac agcgctgccg ataaaccgaa 1033981 gcacaggctt aagtcccagg gctgctgctt tttcttcttc cattaccaaa agagcggctg 1034041 ctccgtctgc tatgccactg ctgttggctg ctgtgactgt tccggagctg gtgtcgaaaa 1034101 ccggctttgc acggggaata atcgcttcta ttggccgcgt tttcaaaaat gcttcgtccg 1034161 tctccaattc cccgagagca acaacttctt cacggtaaaa tccttcatca tgcgcgttcc 1034221 tgctgcgttg atggctgaga agcgcgtact catcctgcat gcttctgctg atggaatagc 1034281 gtgcagccgt atattctgcc gcaatgccca tgtctggatc gccgatcgca tctggagaaa 1034341 agcgagcccg ttctgaaaaa ggggattggc tgctgctttc tgagccgccc gcgatataca 1034401 tcgtgccggc tcccgcttga ataaggctgc aggcatagcg cacagcttca aggccggagc 1034461 cgcactgtct gtcaattgtc attccgggaa ccgataaagg cagtccggct tgaagggctg 1034521 acagtctggc caggttgccg cctctgccag tagcgtttcc gagaatgacc tcgtcaactt 1034581 gatcctctag ctttcggctg agacagcgga tgatgggagc cgccaaatcc tccggcagga 1034641 agggcttcag cagtccgttt tgatttccaa agatcgttcg ttttgcatca acaataaccg 1034701 cattcattta tactgtacac tctcttccag ccattttttc actctggaac gggcaatttt 1034761 tccgctgctc gtttccggca agctgtctgc aaacacccat tttttcggaa ttttatagga 1034821 ggctaatttc tgtttacacc aggctttcag tgttctggca ttagcgtttc caagaatgac 1034881 agctacagcg atttctcccc aatactcgtc gggaatgcca acgacagccg cgctttcaac 1034941 ctctgggcag gcgagaagca cacgttcaat ttcttctggg aaaatattta atcctccgta 1035001 cacgatcatc ccgttttctc ttcctgatat gtatagaaag ccctcttcat caacgtagcc 1035061 catatcatct actgtcatcc attcatctgg tgtgctgccg ttcacatagc cggaaaacct 1035121 catcgggctt ttgacaaata tttttccgat ttctcctggc tggcagcgtt ctcctccagc 1035181 gttgcggatt tcgatccgga cattatgaaa agggcggccc gctgaatgcg gcttccgttt 1035241 gctgtcttcc ggtgaagaaa acgtcacaaa actaagctct gatgtgccgt aaaaatcgta 1035301 cagcttgaga tgaggccatg cagcggcaag cttcttcttg gattctgccg gccagtctgc 1035361 gccggatgaa atgattttga cgggactgtc gggaaaaccc tcaatccttg cgagggcgtc 1035421 tgtcatcgtc ggtacggtat agagaacact gatggattca cggcacagcc attccttcgc 1035481 tttggcagga gaaaactttt tcagcaaaca aacggttcct ccgagaaaca aagtgctgac 1035541 agccccatat aggaagtgag aggacattaa cgctccggga atcagaacct tatcatctga 1035601 tgaaatcgaa aaatctgttt ctgtacaggt aaagctctcc atccatgagc ggtgagatcg 1035661 cgtaaaggcc ttcggttttc ctgtcgagcc cgacgtaaat cccatataaa aagggtgctc 1035721 cggatcaatg gtaggcaagg gatcagcggc tgcctcagaa atatctgcca tacagttatc 1035781 cagcaataca acaggtgtct ggctatctgt cagtttgttt ttgaaaaagg ctaaagtaac 1035841 cacaagatcc gcattgctta tggacagccg ctccttacat tcagccgggc tccagcgtgt 1035901 gtcgatggga atggccgtac atccagccgc tgcggctccg gcaaacagct gtaaaaacgc 1035961 gagactattt gggagcagga tcgccacacg attcggcatg ctcggctgtg accgcagcca 1036021 atttgcggtt tgagagacaa gccgatccca atcatggtac gtgatttgct ccgattcagt 1036081 ctggatcgct acacggccgg gcgatgtttc ggcagtagat gaataggtat gagtaattgt 1036141 catgtattgt catcctcctt ttgtaaacat cgtatcagaa agagacaagg cttgagtgat 1036201 ttttatcgcc agaaatgcag atacagccgc ttttatcaaa tcaccaggca catatgcaag 1036261 gctcatgaag gcggcctgtg acaaatcaat atgcatgata aaagcttgta ccggtatacc 1036321 aagcagataa ataaagatga tgccgaatac gatatgagtg aaaaagagac gcaatactgt 1036381 caccttccgc agcctgttag cggctaaact gatcagccat gaagcgaggg gataagcaat 1036441 caaaaagcct gcgctcggtc cgaaaaacac accaaaaccg cctcgtccgc cgggcaacag 1036501 cggcgctccg aaggcgacga gcagcaaaaa gacaagctgg cttaagaaag cagactttgg 1036561 cctgagaatg ctgcctgcca acatgacacc aagcgtttgc aatgtaatcg gaacgggtgt 1036621 aaaggataag aagagagggg gcataaagcc gagcactgcc atcagcgcgg tgaaaatcgc 1036681 aatatgcatc atgtcgatta atttcagcat gtgaaatcct ccaaaaagta atcaaatatg 1036741 gttatacaat aaatgcaggt aattattatg tcaactgatt tttaatttaa gtttacataa 1036801 tgaacgcaaa aaaaccggcc gtatggcaga ccggtttttg atggttattc ttctgtcagg 1036861 atgacaagcg aatcaacgga agcggccaca tgggaaacgg cgcggctgac ttcctgaagc 1036921 cctccaagaa aggcttgcag atcgacgtcg attttgcctg attgctcttt gctgattttc 1036981 atgctgtgga cgatttcatc gaataagcgg ttaatttgcg tcattttttc tttactttcg 1037041 ctgactagct cattcacgtc tttgatatgc ttggatacaa tgttgatttg tgtattcgta 1037101 ttgttcacaa gctcagaaac agtagagacg gtttttttcg tatcctcaga aagcttccgc 1037161 acttcatttg ccacgacagc aaagcctttg ccgtgttctc cggcgcgggc ggattcaata 1037221 gatgcattga gcgagagaag gtttgtttgt tcagctatgc ctgtgacgat gccgaagatt 1037281 ttttcaattt gctgcgcgat ttcatccagc ttgaccattt ctttttcgat ttggacaagg 1037341 cttgtgtcaa ttttgttcat ctgtttttgc tggacttcta gctctttttt tccgccgatc 1037401 gacttttctt caacagtgct ggatgttaca gtgccggctt tggatgcttg agaaatgcct 1037461 tcagatttgt ccacaagctc ttgaactgat ctgcttgttt ctgaaaacag attggcaatc 1037521 gatccagagg tttcttgaat tttctgatga agaaggtttt tcttttcttc ttgttcatca 1037581 cgggtctggt tgtactcgct ttgaaacgct tcaaggacaa gctgctgttc taagttcaag 1037641 atttttgttg ttgctttaat ggcttttagc agttcttgct gatttgtaat ggacgcttca 1037701 taaatgtcaa tcattgacaa aaggagctct tgaaacgcac ccatatacca ttttggcaaa 1037761 aggccgattc ttaaatggat ggaggcgatt cggttacgct tttcaataaa ttcatcatcg 1037821 ataacgcctg caaacatttc ctgaatatgc cgttttaacg tttgttttaa gcggtcaact 1037881 gagctgtgat cattaatgat atccatcaat gagctttcat ggtcaaggtt tttataaaac 1037941 gcatcgacga tatttacgat attttcttga atgagtggct gaagctgctc taacacataa 1038001 agctcagcat ctcccaacct gaccattttg agctgttttt tgacatctgc atgtttgttt 1038061 gtgagctgaa tgcggttttt ttgttgtccg tttgaatctg aaaagtaagc tgtttcttgt 1038121 tttctgtctt ttttaaataa caatacaatg atcccccttg ggaaaaatat aatttttact 1038181 ttttggcttt ttaagccttt ttctttttta tcggccaagg gaaacatgaa tgaagctgca 1038241 gatgaaaaat atttgaaaaa acgttcatta aaatgaacgg tttaatcgag atctatttgt 1038301 tttaatggtt taatggccgg accctctaca acttcgccag atggcttaaa gcgtgatccg 1038361 tggcacggac aatcccacgt atgctcactg tcgttccact cgacctcgca gcctaaatgg 1038421 gtacaagtcg tatcaacgag atggaggcag cctgtctcat cacgaaatgc tcccgctcgc 1038481 ctgccgttta tggtgacggc tttcccttct cctggcgaaa tgtcttcaaa ttggacatca 1038541 ggcttttcaa gctttccttt tatcaaatgc ttggcgacat ctgcattgta ggaaatcact 1038601 ttctgcaacc cgggattcag atggaaacgg gacggcgtga aaatgctttc gtatgggttt 1038661 tcttttttct ccacaaggtc tgacaataaa gtggctgcga ctgctgagga cgtcatgccc 1038721 cattttttga acccggtcgc tactagaata ttgtcctcat tttccgacat cggcccgata 1038781 aacgggattt tgtcgatcgt cactagatct tgggtggacc aataatatgg aatgctttcg 1038841 atgccgatgg tgctttcggc cagttgtctc agtgtttcat aatgtgtaga catggctttt 1038901 ccctggcctg ttttatggct tactccgctg aagagaatca gcttttcacc gtttacaacc 1038961 gtatagcgga gcgccactga cggctgatcg atactcaaat acatgccctc gggatactcg 1039021 atcttcggct tgatggcaag gacataagat ctgtcggagt acattctcgc agcatataat 1039081 ccgcctccgt cataaaaagg gaagtgggaa cagcatatga taaagcggct cttaatggcg 1039141 tgccggcttt ttgttaccac ttcgggcctt tcgccttttt tgatatcaag cgcaacggtc 1039201 tcttcataaa ttcggccgcc tttttgaaca atttgctcca gaagcgcttt taagtattga 1039261 agcggatgaa attgagcttg attcttcatg acaagcgcca gcttagaacc taagggaatt 1039321 ggaagatcct tgataaggtc tctttcaatt ccgagctttg tgtatgcctc atgctcggtg 1039381 tggatttttt gaacagcgtt ttcatttgcc gtataaagat atgcgtcttg ctcgatccat 1039441 tcacaatcaa tttgatgttc atccacaatg ccttttatgt aatcaattgc gttttggttt 1039501 gcttcataat aaagcctcgc atggtttaat ccgaaatggc ggataaattc gtcgtatatc 1039561 atgtcatgct gtgcggtaac tttagcagtt gtatgcgcag tggttccgtt aagaacctga 1039621 tttgcttcaa tcaaaacgac acggaagcct ctcttcgtaa gttcatatgc cgttgtgatt 1039681 cccgtaatcc cgcctccgat aatggtgacg tcacattcag tgtcctcttg aagcgcagga 1039741 aaagaaggca ggtcagttga tgttttccag tatgtttcag gtgcttcctt tgcaaaatgt 1039801 tgattagcca agccgttata cctccaatca gatttattct taatttttcc atattctatc 1039861 ttttcataca taggaagcag gcattgttca taacataata aggttgaaaa ggagtgattt 1039921 cattggcgaa tcaaaaaaag aaaacattac cgcctcagca ccagaaccag cagcctggtt 1039981 ttgaatatct gatggacccg cgtccggttt ttgataagcc gaagaaagcg aaaaaattag 1040041 agggcaaaac cgctattatt actggaggag acagcgggat tggacgcgct gtctcggtgt 1040101 tattcgcaaa agaaggggct aatgtggtca ttgtgtattt gaatgaacat caggacgccg 1040161 aggaaacaaa gcagtatgta gaaaaggaag gggtaaaatg cctgctgatt gcaggagatg 1040221 tcggggatga agcgttttgc aatgatgtgg tcgggcaggc aagccaagtg tttccatcca 1040281 ttgatatatt ggttaacaat gcagctgagc agcatgtcca gcccagcatt gaaaaaatca 1040341 ccagccacca gctgatcaga accttccaaa caaacatttt ttccatgttt tacttaacaa 1040401 aggcagtgct gcctcattta aaaaaaggga gctctattat taataccgct tcaattaccg 1040461 cctataaagg caataaaacg ctgatcgatt attcagcgac aaaaggcgcg atcgttacgt 1040521 ttacaaggtc cctttcccag tcgcttgttc agcagggcat acgggtcaat gcagtggcac 1040581 cgggtcccat ttggacaccg cttatcccgg ccagctttgc cgcaaaagac gtggaagtgt 1040641 ttggttcaga cgtgccgatg gaacgcccgg ggcagccggt cgaagtggcg ccaagctatc 1040701 tataccttgc cagcgacgat tccacatacg tcacagggca gacgattcac gtcaatggcg 1040761 gaacaattgt gaacggataa taaaaagcca atccttgaag gattggctta ttcgctctgc 1040821 ttgagcgctg catattcttt agagagcgta agaaacgcat ctttatcttt ttcgtccaag 1040881 gctttgttaa tttggtccgt cagcatggca agccgacggt tatacaagga ttcatcgagc 1040941 accatttgaa tgtaaatatc cgtcattgtg acatcgaatt cttttgtttt ttgcgtgttg 1041001 cgggacttca tgagctcagt gtacgatttt ttctctttca taaagaatcc ccccaatgcc 1041061 ttttttatag tatatggata acggtcgaaa aaatcaataa atttttataa tttttagaca 1041121 actaatactt ggcaatctat cgacatatcc tgcaaaatgc cgtaaaccgg caagtcttat 1041181 gaaagtaaaa tcggtttatt actagtcatt tagtaccatt aaatatcatt aaaagatgat 1041241 tttatcttaa atgttaaaaa aacctgtcgt tttacaaaaa cagatgatag attattagta 1041301 taaattttgc agaaaaagga tggaggccat aatatgagtc agaaaacaga cgcaccttta 1041361 gaatcgtatg aagtgaacgg cgcaacaatt gccgtgctgc cagaagaaat agacggcaaa 1041421 atctgttcca aaattattga aaaagattgc gtgttttatg taaacatgaa gccgctgcaa 1041481 attgtcgaca gaagctgccg attttttgga tcaagctatg cgggaagaaa agcaggaact 1041541 tatgaagtga caaaaatttc acacaagccg ccgatcatgg tggacccttc gaaccaaatc 1041601 tttttattcc ctacactttc ttcgacaaga ccccaatgcg gctggatttc ccatgtgcat 1041661 gtaaaagaat tcaaagcgac tgaattcgac gatacggaag tgacgttttc caatgggaaa 1041721 acgatggagc tgccgatctc ttataattcg ttcgagaacc aggtataccg aacagcgtgg 1041781 ctcagaacca aattccaaga cagaatcgac caccgcgtgc cgaaaagaca ggaatttatg 1041841 ctgtacccga aagaagagcg gacgaagatg atttatgatt ttattttgcg tgagctcggg 1041901 gaacggtatt agaaaaatag gaaggagctg accgaacagg gcagctcctt tcataaagct 1041961 atgccgtcgg aattcctccg gtgatgccat atacctgaga tgtcacatag cttgaattct 1042021 ctgaagctag aaatacataa acatcggcca attccactgg ctgcccagcg cgatttaatg 1042081 gagctggcgg cgtgccttgt ccgaatttcg ggatgttttc cgtcggctgt ccgccggaaa 1042141 tttgcagcgg tgtccaaatt ggtccgggcg caactgaatt tactctgatg cctttggaag 1042201 caagctgttt tcccagtccg acggtaaagc cgataatggc gtttttcgtt gctgcgtaat 1042261 ctaacagcat cgggcttgga ttatagcctt caactgaggt agttgtgata attgaagctc 1042321 cctccggcaa atacggaagc gccgctttta caacccagta aagggaaaag acgttcactt 1042381 caaatgtttt atagatttgt tcagtaggca gatcttcgat gttttcgacc gcttgctgtt 1042441 tgcctgcaac gagcgctagc acatcaagtc cgccgagttc gtgatgcgac tgtttgacta 1042501 gatcttggca aaaggattcg tcgctcaagt ctccggggat cagcactgct tttcggcctt 1042561 ctgcttcaat cagctctttt acctcttcag catctggctg ttcctcgggc aagtagttaa 1042621 tagccacatc ggcaccttct ctggcgtaag caattgcggc agcgcggccg ataccggaat 1042681 cgccgcccgt gacaagcgct tttcgacccg ttagtttacc tgatcctttg tagctttttt 1042741 ctccgcaatc agggacaggc ttcatgttct tttgcaggcc tggcggttct tgatattgtt 1042801 cgggaaattc atcatgaaaa aatgctttta taggattcgt aagatttgaa tcagacatca 1042861 gcaacgctcc ttttctgttt ggtgtacatt cgtatgtgta cccctgagca taagcagaaa 1042921 aacatgtttt ggcagtttga atagtgaagg aaaaagaaaa caagaaaaaa caaagccttc 1042981 ttccatattt atcttgtcaa ataagactat atgaattatg ataaattcga gctataaatc 1043041 aactaaatat tgggtgttgg gagagtgaat cgtcatgaaa aaagcggcgg cggttttgct 1043101 gtcactcggt ctcgttttcg gtttttcata cggagctggc catgtggcgg aagccaaaac 1043161 aaaggtgaag gtctataaga actgcaagga gctaaacaaa gtatacaaag gcggagtggc 1043221 ccgcacatcg aaggtgaaaa acaaaggcgg aaaaacgaag tacaagcctt acgtttctaa 1043281 ggcactttac gatgccaata aaaacaaaga ccgcgataaa gatcttatcg cctgtgaacg 1043341 gtaaataaga aaaagcaatc tggtgtccag attgcttttt ttatgcttag gccgcctgat 1043401 cggccgcagc gcttttcgcc ttccttgtca taaggctgac tgccatcatg accgtgatat 1043461 tcaaaagcag ggcgacgatg ccgacattca agtcttttgc ggcttgcggc agagccggaa 1043521 ataaagtgcc gatcgtcgtt tccgtcattg taatataagt aactgctccg acacctgcaa 1043581 taatgccggc gaaagctcct tgctttgtca ccatattatg cttgagcagg ctgaacaaaa 1043641 gggcggggaa tagctgtgtg acaaggctgt agcccatcaa aagcagcgta acgatggtat 1043701 tcccgccttt gaaggtaaaa tacaccgaaa tcagcgcaat caccggcact aaaaacttag 1043761 caagcgccga tacttgctgt tctgtcgtgc ggggcgcgat taccttgtac acattttttg 1043821 caaacagtgt ggaggcggac attaagatca tagaccctgg cacaagtgct gtcagcagtc 1043881 cggcagcacc gataattccg acaaaccaag ggtcaaatgc ttgcagagac agtctcaaaa 1043941 gcgacaaatc cccgtctgcg ccattcagat ctggaacttg caggatagcc gcaaagccga 1044001 cgaaaaggac gaagagcagg accagctggt acaaaggcat gatgatggcg tttttacgaa 1044061 acacttttgg gttttcggct gaatacgaag cggaaaacgt gtgaggccac atgtaaaaac 1044121 caagcgctgt caagagtacg gttgaactga accaggccac actttgtccc gattcgggga 1044181 gcgtaagaaa gccaggcttt gccgtttcaa tctgctgaaa catgtcttga aatccgccgt 1044241 agtaatgaat tggcaaatac acacctaaaa acagaacgac aaccagaatc atgatgtcct 1044301 tcacaaccga tatccaggca gacccgtgaa tgcctgaaac cataacataa accgtgatgg 1044361 aaacagcgcc gatccagatg gcagcggtcg gggtgatttt gccgtacgag gtttccgata 1044421 caatcagccc gaggcctttc agctgcagta caagataggg aatgagtgcg gcgatgccga 1044481 ccagtgaaac gagaatgcca agcagcggac tgttgtattt ttttgtgaaa aaatcagact 1044541 gcgacatcag tttatgctgt ttcgcgtacg tccaaactgc tggaagaagc cagtaagaaa 1044601 ggatgtaggc cagacatccg taggcgatga tataaaaggc tggaccgcct tttccgtagg 1044661 cccagccgct gccgccgaga aacgtaaaag tagtataaat ttcgcctgcc atcaaaagga 1044721 agacgaaaac agttccgaag ccgcgccctc cgaccgtcca ctgctccagg ttcatgtctt 1044781 ttcctttttg ggcgcgtata ccgagaaaaa tactcaagag caggacaccg aagatgatga 1044841 tgagagctgc attcattctg cttcctcctt tttattttcc ttgtcgagga catacacaat 1044901 cgccatcagc gcagaggtca aaagagccca catcacaata taggcaagaa taaacggcat 1044961 gccgaacaca tagggggtca ccttatttgc aaaagggatg ccgagtaaga ttccgataaa 1045021 gggtaaagcg gcaagaacgt gaatcagttt catagaatcc tccttctatt taggattgag 1045081 gtgtacaagc ctaagcgtac tgaaaatgat gtcgcagata tcgcagcaca tgtcattttt 1045141 tggagtgaaa ggctgtggtt cgaattataa ataaatttat tttgtttgta tagtgtgaat 1045201 tgtctgaaat taatgctctg aatcgcccga agagggaacg ggcagtatga ttcaaaaggc 1045261 tcagagtctg tctggggcaa atagatagta tgttaataat tcgctgacct gctcacggat 1045321 tcgcggatta aaatagcgat ggttttcttc ataaccgtcg atgacaaatg tatagagtgt 1045381 aaaggcctca tcgcgttccg tctcgcggat tgcaattttt cttttcctca gttcttttct 1045441 gacctccatc aaatcctttt gtgctatttt taatgattcg ctgataagct gtttataagg 1045501 atgcttcaat tttaatgtgc tttcttcaat tccggcgaga tcacggttaa aaatcgtaat 1045561 ggccatgggc aaaaagagag cccgttcaat taaatcgtat atttcctcct gcagatttgg 1045621 catattgact ccttctttct aagggaacgt ttgttctatt tgtattctat atcggctggt 1045681 gaaatgtttc aagacagaaa aaatcaccaa aactttttag ttttctgctg ataatgtgta 1045741 gaataaggat agacaaaccc ggtaaggagt ataaatgttg gagcattttt tatcctattt 1045801 gacacaagaa catttaactg aattatttca aagctatagg gctttcggtc cgctcattgc 1045861 tgtgctgctg cctttaattg aagcatttct cccgtttttg ccgctgatcg tgtttgtggt 1045921 ggcgaatacg aactcgtttg gcttgtggga aggattcatc ctatcctggg cgggatcaac 1045981 tgctggttcc attctcgtct ttttgattgt ccgtcaatac ggacagagaa aattgcttgg 1046041 atttatccgc agtcatccgt ctgtcagaaa gctgatgtta tgggtggaaa gacacggctt 1046101 cggtcccatg tttcttctgc tttgttttcc atttacaccg tcagccgcgg tgaatgttgt 1046161 tgccggtttg tcaaggatcg gaacgcggcc gtttattttg gcggcagcct cggggaagct 1046221 tgtcatgatt tttatgatca gcttcatcgg atatgatctg cacgcgctga ttacacagcc 1046281 gattcgaacg gtcatcgccg tattggtgat cactgtctta tggtatgtcg gcaaaaaggt 1046341 ggagcggtat ctgcatgtaa gagccagtca gcgtgagcat gatggaggga gacagtaaca 1046401 tgaaaaaacg gttttggttt cttgccggtg tagtgtccgt tgttctcgcc attcaggtta 1046461 aaaatgctgt ctttattgat tacaaggtag aaggcgtcag tatgaacccg accttccagg 1046521 aaggaaacga attgttggtc aataaatttt cgcatcgatt taaaaccatc catcgttttg 1046581 acatcgtcct ttttaaaggc cctgatcata aagtgctgat taaacgggta atcggcttgc 1046641 ccggtgaaac gatcaaatat aaagatgatc agctgtatgt gaacggaaag caggttgctg 1046701 agccattttt gaagcatttg aaatctgttt ctgccggcag ccatgtaacg ggtgattttt 1046761 ctttgaaaga tgtgacggga acaagcaagg tgccgaaagg aaaatatttt gtcgttggag 1046821 ataatcgcat atacagcttc gacagccggc attttggtcc gataagagaa aaaaatattg 1046881 tcggtgtgat ttctgatgcc gaataaaaag acgctaattg aagaggcgtc tttttgtatg 1046941 ccgtttggaa aaatgtgttg aagaaaaatt tgtaaggagc tataatcaaa attgttacct 1047001 gtgtaacaaa atttatatat ttttttgact ggagggccgt ttttattggt ttttgttcgt 1047061 ttttcatgaa acaaaaggag tggtgaatga tgatgaaata tgaagcagtg attataggag 1047121 gagggccggt tggatttatg ctggcttctg agcttgcaat agccggagtg ggaacatgtg 1047181 tgattgaacg gcttgaaaaa cctgttccgc attccaaggc gttgacgctg cacccccgaa 1047241 cgctggagct tcttgagatg agagggattt tagagcggtt cgtatccaag ggaagcaaga 1047301 tacctaccgg acatttttca atgctggata cccgtctgga tttttcaggc ttggatacga 1047361 gctgtcctta cacgcttttg ctcccgcagt ccaaaacaga aaagcttctt gaagatcatg 1047421 cacgaagcct gggaacagag gtgtttcggg gtgccgaggc gctggcggtt acgcaaaacg 1047481 gggaagcggt ccaaacaatt tttaaggatc gggacggcag tgtacggacg atcacaagca 1047541 agtttgccgt tggggcagat ggcgccggga gtaccgtccg gaaacaggcg aaaattgagt 1047601 ttccgggaac agacagcact gtcaccgctg cgcttgggga tgtggtgctc ctttctccgc 1047661 cgccgtcagg tgtgctgtcc ctttgcacaa aagagggcgg tgttatgatt gttccgttat 1047721 ctccagaccg ataccgtgtc gttgtgatca gcccttatcg cacacaaacg ccgaaagatg 1047781 tgcctgtgac tgaggaagag ctgaaagctg acctcctgcg aatttgcgga actgacttcg 1047841 gtttaaccga cccttcgtgg atgtcgcggt ttgggaacgc cgcgcgccaa gcgaaacggt 1047901 atcgggacgg cagaatcttt cttgcgggtg atgccgcgca tattcatttt ccggcgggcg 1047961 ggcaaggact gaatgtcggc cttcaggatg caatgaacct cgggtggaaa ctggcggcgg 1048021 ccatcaaagg ctctgcgcct tcttggcttt tggacagcta ccatgatgag cggcatccgg 1048081 cagcggaagg gctcctcaga aacacggagg cacagacaaa gctgatcgat ttcactcaag 1048141 caggcctcca tttgcgaagc atgatgtcgg agctgctggc cttccctgat gtgaatcgat 1048201 atgtagcggg gcaaatttct gcgctcgatg tcagatatga agctgatcgt accatgccgc 1048261 cgaatcgttt gaacggggca aggctccctg acatgaagct gattctttcc gacggcaatt 1048321 cggaacggct gtacagcttt ctccaaaacg ggacattcgt tttgctgtca ttgaggcagg 1048381 aagctgatga tcatatcgaa gtaaaaggct tacgtacggt aaccgcctcg cttgcagaac 1048441 cgaatgaaaa gttgcggaat gtgcatacca tattgattcg tcccgatgga catgtagcct 1048501 gggcggtgga tgcatcagcg cccgattgtt ccgaggtgat tcaaaaaggg atcagccgct 1048561 ggttttccgt caccagccga gtataattca attcgattgt ttcatctgta acaaaacggt 1048621 atgatagaag aaacaatcga atgaaaaagg atggaaaacc cgatgaacac agatcatacg 1048681 aaacgcaatc tttttgaatt gtatgcggag ctcattcatc agcaggagaa atgggagggg 1048741 cttattaaag cctttttatc tgacgaattg aggaagctgg atgtagagca cgggagtaaa 1048801 tctcaattga cgatgacaga aattcatgtt ctatcctgtg tcggggacaa tgaaccaatt 1048861 aatgtcacgt cgatagcaga aaaaatgaat acgacaaaag cgactgtatc acgcatcagc 1048921 acaaaattgc tcggcgcagg cttccttcac agaacacagc tcagcgataa taaaaaggag 1048981 gtctacttcc gattgacgcc tgctggaaaa aagctgcaca gtttgcacaa atattatcat 1049041 cagaaggctg aacagcgttt tctgtcattt tttgaccgct ataccgagga agagattctt 1049101 tttgcggaac ggctgtttcg ggatctggtg acaaaatggt atccgtcgtc agaagaaatt 1049161 gaaggggggc ttcctagcat ttttaaataa aaaacacgca ctgcggtgcg tgtttttcgc 1049221 tttgcggccg cctcgagaat tctttcattt caccctctgg cagcactcac ttcaaatctg 1049281 atccattaac aacgaaatat ccgcttatat ttcctcatct cgatggtttg cgaattaaaa 1049341 gttcttgaac ccttttttca actaggcact actgccgctg attgagctct ttttgtcttt 1049401 tttttcacca tgaagatggt gaagcaggcg ataaaacggc ggcagcaggg caataaccag 1049461 aatgacgcga atgacctgaa ccgcaacgac aaaggtggaa tcagcatgta aggtaactga 1049521 cgtcgtcgcc atctctgcaa tcccgccggg cgcaaatgcc agaacagaag tgatgagcga 1049581 aattcctgtc agctcggaaa cgatcacggc gctcaaaaac attgctgcga ttaaaccgac 1049641 ggacgagaca aacccgacga tgataatacg ggtgacgccg gcaaacatgc ttttgtacat 1049701 cttagagccg atcgttgccc cgagaaatac ttgtgataca tggttagctt gtgacaacca 1049761 ccatgccgtc atgtcgtgcc ctgtcaccgc agctccgcca acatgtacaa ttgctacacc 1049821 gagcatgctg ccgagcagcc atggagctgg aaattttaaa aatttcgcag ctttgcaagc 1049881 tccccaggca gcgagaataa gaatgacggt ccacaaaacg ggagcgagcc taaaatctgt 1049941 cgttgcagaa gaaatcgtct ctgctgcggc acttgcggta cgatcttgtt ttgtatagat 1050001 cagaatgact aaaaacggaa tggaaagcac cacgagcagc acacgcatca tttgaacgag 1050061 gctgactata gcggtattgg cgcctacttc ctgtgcgatg ctcggcatgg cggaaagtcc 1050121 gccgggagcg gtgccgacaa agctagtcat catatccgtt ttgctgaaac gccaaagcac 1050181 atatcctgac agcatggcca gcaggataga caatatcagc ataacgccga ctgaaaacca 1050241 atggtctttg agaacagaga gaacggataa attcagcttt tggcccaatt cgatgccgag 1050301 gatcatctgc ccgagggcga gccatcgtcg gttaattcct ttttggtctg gtgccatcat 1050361 cagccatgcc ggccgtatca tggcgaggca gcaggcgaca atcagtgttc cgatcatcca 1050421 tccaattgat attccggtta atgaaagaat aaaccccccg gctgcactga ttgcgataaa 1050481 ccatagatct ttgaggagat tttcgtcttt cttcaatgta aaacccttct tcctttttca 1050541 cgtaacactc caattgttca cgtagtgaat gtatttatta ctatagtata tttttgttga 1050601 taaagaaatt atgaattatt ttctataagc gattcacttt tcttatgacc ttgtgttcga 1050661 gcttttctat tgtgtaagtc agagataaac ccgctgtcag cagacacacg gcaagagcgt 1050721 aaaaaatcac ttctccgcca aatgatgtca ggatcagccc gcctgccagc ggtccgattg 1050781 agcgggatat atcccaatgc agaccataga cagcataaaa ccggcccagc aaatgaggcg 1050841 gcgccaattt cgatatgaag gtctggatgt gggttagccc gatgctttca ccaaccgtca 1050901 tcaccgctgc cgtcactaaa agcattgtca gagaggttga gcatgcaaag ccggctgccg 1050961 caagggagta gcaaatataa gtaatgaaga ggatcgtttt cattgaaagc ttttcggtcc 1051021 ctttgacaag aggtacttgg agaacacagc tgaataaagc ttttgctgct gaatagatgg 1051081 tcagcatgga cagataatca gaaaacatgt ttttgctgaa cagcctgtat gttgtttctg 1051141 tttgtgcata taacatgctg atggggagag aaagcagcaa aagaagcagg acaggcctgt 1051201 atattgtaaa gctcgcggac attttcgggg taacagctgg gtgtagcggc tttgtctcag 1051261 gcagtttcag tgcagcgatc agaaagtaga taaacaatgc tgcagcatct aatgcgaata 1051321 tccacacggg gttatgattg tacagcagca tccccactag cggtcctgcc gtcagacccg 1051381 tcgaatagat cgcattgatg accgcaaaca cttccgaacg tctgctttcc ggcgtgcttt 1051441 cagcgatttg ggcgcgggaa gcgggaatgt acaacgatct tccgatgcca ttcatgacat 1051501 agagaatagc gaaaacatac gcatgctcag caaatacaaa ccctgtcatt gccgctgatt 1051561 gaagaagcaa tgcggtcaaa atcgctgtgc gccgcccaag ccgatccgtc acccgtcctg 1051621 cagcgagcgt caggaaaata tcagcaaatg gctgaaggct gatgatcagc attggcatca 1051681 tgatactgcc gtttaattgt tcatgcagat acagcaccat aaaaggtccc atcattgcac 1051741 ctgtcaggct tgtcagcaat tcgccgaaaa agcggagccg aacgggagcg gtatatctcg 1051801 attttataga gtgaaaactg gtcaacatgt gatcgccgcc tttcgctgtt tgatatagta 1051861 gtagtgtata gaaggggcgg cggcccaaaa agtgaagaaa agaagagata aaagttcccc 1051921 ttttgtcggg aggtgcgggg attgaagctg atagagcact acgtggcgct tgtaaaaaca 1051981 ggctgcgccg agtatgggca aatgaacgaa atgacgctca ctgagattgc cgactgttta 1052041 ttttgtacag aaagaaatgc aaagctcatt ttacataagc tggagaacag caattggatt 1052101 atccgggaaa gcggggcggg gcgcggccgc aaatctaaaa tcgcgtttct tcggaggcct 1052161 gaggaactgc ttcttcaaac tgcaaaggaa tataccatgt caggaaagct taaaaaggca 1052221 aaggagctgc ttcagcagta tcagtccgcg tttccagggc ttcaaaacga atataacatg 1052281 tggctatcag aggtattcgg atttgtgacg gagacaggcg agaatggggc gaaggatgtc 1052341 ctgcggctgt tcatcacgcc tgaatctgtc agcagtttgg atccatgcca aatatttttg 1052401 cggtctgagg gccatttcgt caaacagata tttgatacac tcttcacgtt tgattcggat 1052461 atgcaggagc cgaagcctca tttggttcat ggatgggaag aggtcggaaa aaaacaatgg 1052521 agattttttc ttcgaaaagg tgtgttattt cataatggac agccgctgac atcgcgggac 1052581 gttgcgttta catttcagcg ctttttggaa ctggctgaca acccgtataa atggcttctg 1052641 cacggagtga aacaagtctt agaaaagggc ccttattgtg tggagctcat actcgataag 1052701 ccgaatgcgc ttttgccgta tgctctttgt gatgaacggc tgtccatact gccggcagaa 1052761 cagggcggcg ggaaaaatgg aacagggcct tttcagatga atcagcaaca tagcgggatg 1052821 cttgtgcttg aagccaatga gcgctacttc aagggacgcc cctatttgga tcgcgttgag 1052881 tttgtgtttt ctgagcaagc cggagagatg aacggtttta ccattcaaga aaaacaaaca 1052941 tgtcctgagc agcaaactgt ctttgatgag cggcatgttc agtatttgtc gcttaatctg 1053001 aaaaagaagg ggcctcttca gcaccgaagc tttagaaaag cgctccggct gctgatttcc 1053061 tctgaacggc tcgttcgtga agcgggaggg caccgaagaa ttccggttac gtcctttttg 1053121 catccgagtc cttttgagtg ggagggcgtt tcgccatctg aattgttgaa aaaaagcgga 1053181 tacgagggcg aaacaatcgt gctttatacc ttttcggaaa cggatcatcg tgaggacgcc 1053241 gaatggattc aaaatatttg cgcccagcac ggtatcaggc ttacacttca attctgtgat 1053301 gctgctgatc tgcgacggcc ggaaatcgtg cagatggcgg atatcattca tgacagtgcg 1053361 acgttttatc aagacagcga gtttggtttt ctgcatttgc tgctgtcgga gaacagtttc 1053421 ttgtatcagc atctatctga aaagctgaca cagatttgct caggaatgac agagcggatg 1053481 ttttccatgc ctgaccgctg ttcgagaatc aacatcctgc gtgacattga ccggcagatg 1053541 atacaggagc tgaacgcgat cccgctgtat caaaatgtgc tccaggtgac atcaagtaaa 1053601 aatgtaaaag gcctggtgct tgatgaagag ggatggattg atttgtactc cgtatggctg 1053661 tccaaataaa aagagggttc ttttttgaac cctctttttt acgctgccat gctgcggcat 1053721 tgttcagcac aggtgaagca ggctttcgca catgcttggc aatgatcatg atcgtgcttt 1053781 ccgcattcag tgccgcatgc ttcacaaata tcggcgcaaa gtgcacaaat ttctttcata 1053841 aacgggctgt ccgtttgcat ggctttgacc gccagcgcgc aaatatccgc gcattccctg 1053901 tcaagccgga tgcatccgct gagatgatgc tgcacgcttt cttccaagca tttagtgaaa 1053961 caatgattgc aagccttcat gcaatcgatg caagcctcaa tacaagcctc agaatattgc 1054021 tccatggttg attccccctg tatgacagta tatggtttta tgtttcacgg ctgcatttga 1054081 aaaaaacagg ggagtgtgtt tttagctaag gggatatgta catataccct gaatgggtat 1054141 atctaacgtt ccatcagata gtataggaac cagacagcgt gattttgttc atcacgtgct 1054201 gcgcgcgtaa agacgccttt cgcttttaag tttgacgttt cctcggccgc acgcaagtaa 1054261 aagtcgacgg tttcttgttc atctttaaaa gcggcgtcca gtcctcttgt gaaattgtcc 1054321 gggcattctt ccgtttgttt cggcatgatg tgtttgccgg taattgaacc atacagtgtg 1054381 gaaaattcac ggaggtggcg aatctcgtca cgcctgattt cttcaatctg ttttctgacc 1054441 tcatcgctgt gggcgagttc ggcaagcttg cggtagcatt gaatagcact gaattctccg 1054501 ttgatggcct tctgcaaatt ccgaatcaaa acaggatctt cccggtatgg caccggatag 1054561 ggatagtagc tgtaatgcaa ggggattcaa ctccattctt aggaattggg cttctgtaaa 1054621 agtatatgtt gggcagggag agatgtgcgg agataatcag ctttttatat gtgaaaaggc 1054681 cgtttttacc aatagatcag attggtcatt ttcgtcaaca ttcgataaaa tatagagaga 1054741 taaaaagaga ggggtcttct aatttgggag cagagttttt agtaggcagg tccgggagtg 1054801 gaaaaacgaa gctgatcatc aacagcattc aggatgaatt gcgccgggct ccattcggga 1054861 agccgatcat ttttctagtc ccggatcaaa tgacgttttt aatggaatac gagcttgcta 1054921 aaacgccaga tatgggcggg atgatacgcg ctcaagtgtt cagtttttca cgattggcct 1054981 ggcgcgtcct ccagcatacg ggaggaatga gcaggccgtt tctgacgagc accggcgtac 1055041 aaatgctcct gcggaagctc attgaggagc ataaacagga gttcaaagtc tatcaaaaag 1055101 cgagtgacaa aagcgggttt accgcacagg ttgagcggat gctgacagag tttaagcgct 1055161 attgtctgga accggaggat atccgccgga tggcggaaag cggaacggct tccgagtatc 1055221 gcggagaacg tgttttatct gaaaagctcc atgacttatc aattctgtat cagcaaatgg 1055281 aaaaaagcct cgcagatcaa tatcttcact ctgaggatta tttgacattg ctggcagagc 1055341 atatcccgct tgcggaagat ataaaaggcg cccatatcta tgtggatggc ttttatcagt 1055401 ttaccccgca ggaattcagg gtgttggagc agcttatggt tcatgcggag catatcacgt 1055461 tttcgctcac agcggacaag ccgtcatatg agcgggagcc gcatgaactg gaattgttca 1055521 gaatgacggg gaaaacctat taccgcctgc atcagaaggc gaaggaactg aatttggaca 1055581 ttacgtataa agagctgagc gggactgagc ggcatacaaa gacgccggaa ttggcgcatc 1055641 tagaggcaca gtatgaagcg cgtccggcca ttccatacgc agaaaaacaa gaagccctta 1055701 ctgtgatgca ggccgcaaac agacgagctg agctggaagg cattgctcgg gaaattcacg 1055761 ccctagtcag agagaaggga tatcgctata aggatgtagc aattcttgcg cgccagccgg 1055821 aagactacaa ggatatggtg aaggaagttt tcgcagatta cgagattcct tatttcattg 1055881 acggaaaagc atctatgctg aaccatccgt taattgaatt tatccggtcg agccttgatg 1055941 ttctgaaagg gaattggcgt tatgaagcgg tgtttcgctg cgtgaaaacc gaactgctat 1056001 tcccgctcaa tgaaccgaag gccaaagtga gagaacaggt cgatcagctc gaaaattact 1056061 gtatcgccta tggtattaaa ggcgaccgct ggacaaaggg cgatcggttc caatacaggc 1056121 gttttgtgtc attggatgat gattttgcgc agactgatca ggaaatcgaa atggaaaaca 1056181 tgttgaatga cacccgcgat tggattgttc cgccgctttt tcagcttcaa aaacgcatga 1056241 aaaaagcgaa gacggttcaa gagaaggcgg aggcgctcta tcgttattta gaagagacgg 1056301 atgtgccgct gaagctggat caggaaaggc agcgtgctga ggatgacggc agaatcattg 1056361 aagcgcagca gcatcagcag gcgtgggacg cagtcattca gctgcttgag gagtttgttg 1056421 aaatgatggg agatgatgag atttctcttg atttgtttca gcaaatgata gaagccggcg 1056481 cggagtcgct tacattttct ctaattccgc ctgcgcttga ccaggtgttt gtcggcaata 1056541 tggatttgtc cagaatgtat ggcacctcct gcacctttgt gctcggggca aacgacggcg 1056601 ttctgccggc acgccctgat gaaaacgggg tcctgtcgga tgatgaccgg gaatggctga 1056661 aaacgattgg ggttgagcta tcctcaggcg gacgagagcg tttgcttgat gagcacttcc 1056721 tcatctacat ggcgttttca agtccgtctg accggcttta cgtatcgtat ccgattgctg 1056781 atgcggaagg aaaaacgctt ttgccgtcga tgatcgttaa gcggctggaa gaactgtttc 1056841 cgcatcataa ggagcgcctg ttaacaaatg aacctgaaca ggtcagcgat gaggaacagc 1056901 tgatgtatgt tgtgaataaa agcgtggcac agtcctttac cgcgagccag ctcaggttat 1056961 ggactcggga atacgacatc agcgacgtct ggtggagcac gtacaatgtg ctgatgagtg 1057021 agcaggacag gctgcaatcg aaaaagctgt tctcaagcct gtttttccgg aatgaagtga 1057081 agcagcttga acgcagcgtg tcgagacagc tctatggtga acgtattcag ggcagtgtat 1057141 cgagaatgga aacctttaac gcatgcccgt tttcccattt tgcgtcacac gggctgcatt 1057201 tgaaggaacg gcaattcttc aagcttgaag caccggatat cggccagctg tttcattcca 1057261 gcttaaagct gatttcggac aggctgcgtg agcaaaagct ggattggcgc gatttaacga 1057321 aggagcagtg cgagctgttt tcctatgatg cggtagagcg gctggcaccg aaactgcaaa 1057381 aggaaattct gctcagctca aaccggcatt attatgtgaa ggaaaaactg caaaaaattg 1057441 tgacacgtgt gtccggcatt ttaagcgagc atgcgaaagc gagcggattc gtaccgatcg 1057501 ggcttgaact gggctttgga ggaaaagggc cgcttccgcc gctgaccttt caactgaaaa 1057561 acggctgtac gatggaactc gtcgggcgaa ttgaccgtgt tgataaggct gaaagctcaa 1057621 aaggcctgct cctcaggatt gtcgattata aatcaagcga caaaggcctt gacttagcgg 1057681 aagtatatta cggattggca ctgcaaatgc tgacgtacct tgatttatcg attacacatt 1057741 cagctgactg gctcgggatg agggcgacgc ctgccggagt gctgtatttc catattcatg 1057801 acccgatgat tcaatctaat ctcccgcttg ggcttgacga gattgaacag gagatcttta 1057861 agaaatttaa aatgaagggc ttgctcctcg gtgatcagga agtggttcgc ctcatggata 1057921 caacccttca agagggacgt tcaaatatca taaacgccgg cttgaaaaaa gacggctctc 1057981 tcagatcaga ctcagcagca gtcggtgaaa aggaatttga tcttttgaca aagcatgtgc 1058041 gccgcacctt ccaagaagcg ggcgaacaaa tcaccgacgg gcgcgtatcc attgagccgt 1058101 acaaaatgaa gaacaagacg ccgtgcacat actgtgcgtt caaatcagta tgccaatttg 1058161 atgaatcact ggaagaaaac gagtatcgcc cattaaaggc tgaaaaggac aagacaatac 1058221 ttgagtggat aaaaaaggag gcggatggca atgaacattc ctaaaccggc agacagcaca 1058281 tggacagatg accaatggaa tgccattgtt tcaaccggcc aggatattct tgtggcagcg 1058341 gctgcgggct ctggtaaaac cgctgtgctc gttgaacgaa tgattcggaa aatcaccgcg 1058401 gaggaaaacc caatagatgt agaccgtctt ctcgttgtga catttacaaa cgcctcagcg 1058461 gcagagatga agcaccgaat cgcagaagcc ttggaaaaag agcttgtaca gcgccccggc 1058521 tcgctgcata ttagacgcca gctgtctctt ttaaaccggg ccagcatttc gacgctccat 1058581 tccttttgcc tgcaagtgct gaagaaatat tactacttga tcgatcttga tccgggcttt 1058641 cggatagctg atcagacgga aggcgagctg atcggggatg aagtgcttga cgagctgttt 1058701 gaagacgaat acgcaaaggg cgaaaaggcg ttttttgagc ttgttgaccg ctatacgaca 1058761 gaccggcatg atctggatct gcaatttctc gttaaacagg tgtacgagta ttcccgatcc 1058821 catcccaacc cggaggcgtg gctggaaagc tttgttcatt tgtatgatgt atcagaaaag 1058881 agcgccatcg aggagctgcc gttttatcaa tatgtcaaag aagatattgc aatggtgctt 1058941 aacggggcga aggaaaagct cttgcgcgcg cttgagctga cgaaagcgcc gggcggcccg 1059001 gcgccgcgtg ctgacaattt tcttgatgat cttgctcaga ttgatgaact gattcagcat 1059061 caggacgatt tcagtgaact atataagcgg gtgcccgccg tctcttttaa gcgtgccaaa 1059121 gcagtaaaag gggatgagtt cgatccagcg ctccttgatg aggcgacaga tttgaggaac 1059181 ggcgcaaaaa aactgcttga aaagctcaaa accgactact tcacgcgaag tcctgaacag 1059241 cacttgaaaa gcctagccga gatgaagcct gtcattgaaa cgctcgtaca gcttgtcatc 1059301 agctatggaa aacgattcga agctgcgaaa caggaaaaat caatcatcga tttttcggat 1059361 ttggagcatt actgtttagc gattttgaca gctgagaatg acaaaggtga acgtgagccg 1059421 agcgaggctg caaggtttta tcaggaacag tttcatgagg tgctcgttga cgaatatcag 1059481 gataccaacc tcgtgcagga atcgattctg cagctcgtca caagcggtcc ggaggagact 1059541 ggtaacctgt ttatggtagg agatgtcaaa cagtcgattt atcgattcag gcttgcggag 1059601 ccgcttcttt tcctctctaa atacaaacgg tttacagaga gcggagaagg cacggggcgg 1059661 aaaatcgatt taaataaaaa tttccgaagc cgggctgata ttttagacag cacaaacttt 1059721 ttatttaaac agctgatggg cggcaaaatc ggtgaggtcg attatgacga gcaggctgag 1059781 ctgaagcttg gtgcagcgta tccggacaat gacgagacgg aaacagagct gctgctgatc 1059841 gacaacgcag aagatacgga tgcaagcgag gaagcagaag agcttgaaac ggtgcagttt 1059901 gaggcaaaag ccatcgctaa ggaaattcgt aagctgattt catcgccgtt taaggtgtat 1059961 gacggaaaaa agaaaacaca tcgcaatatt caataccgag atatcgtgat tttgctccgt 1060021 tcgatgccgt gggctccgca aatcatggag gagctgagag cacagggcat accggtttac 1060081 gccaatttaa cgtcaggcta ttttgaagcg gtcgaagtcg ccgtcgcgct ttctgtgctg 1060141 aaggtgattg ataatccgta tcaggatata ccgcttgcct ctgtgctgcg ctcaccgatt 1060201 gtcggagcag atgaaaacga gctgtctttg atccggcttg aaaataaaaa agcgccgtac 1060261 tatgaggcga tgaaagacta cctggctgct ggtgaccgga gcgatgagct ttatcaaaag 1060321 ttaaatacgt tttacggaca tctgcaaaaa tggcgcgcgt tttcgaaaaa ccactcagta 1060381 tctgagctga tttgggaagt gtaccgcgac accaaatata tggattatgt cggcggcatg 1060441 ccgggcggaa aacagcgcca ggccaatttg cgtgttcttt atgacagggc gcgtcaatat 1060501 gaatcaacgg catttcgcgg cttgttccgt ttcctgcggt ttatcgaacg catgcaggag 1060561 cggggcgatg atcttggtac ggcgagagcg ctcagcgagc aggaggatgt tgtccgctta 1060621 atgacgatcc acagcagcaa agggctcgaa tttccagtcg tgtttgtagc aggtctcggc 1060681 cggaatttca acatgatgga tttgaacaaa tcgtacctgc tggataagga gctcggattt 1060741 ggcacgaagt atattcatcc gcaattacgc atcagctatc cgacacttcc gctcattgcg 1060801 atgaagaaaa aaatgcgcag ggagctgctg tcagaggaat tgcgtgtgct ctatgttgca 1060861 ttaacgagag cgaaggaaaa gctgtttctg attggctcat gtaaggatca tcagaaacag 1060921 cttgcaaaat ggcaggcatc cgcgtcccaa actgattggc ttctgccgga atttgaccgc 1060981 tatcaggcga gaacgtatct agatttcatt gggccggctc ttgccaggca cagagacttg 1061041 ggggatttgg ctggtgtgcc agcacacgct gacatctcag gtcacccggc tcgttttgcc 1061101 gttcaaatga tccattccta tgatttgctt gatgatgatc tggaagaaag aatggaagaa 1061161 aaaagcgagc gcctagaagc gatccgccga ggtgaaccag ttcccggctc gtttgcgttt 1061221 gatgaaaaag cccgcgagca gctgagctgg acctacccgc atcaagaagt gacgcaaatt 1061281 cggacaaagc aatcagtttc tgagatcaag agaaaaagag agtacgagga tgaatacagc 1061341 ggcagggccc ctgtaaaacc ggctgatgga agcattctgt acagacgtcc cgcttttatg 1061401 atgaaaaaag gcctgacagc ggcagagaaa gggactgcca tgcatacggt tatgcagcat 1061461 atcccgctgt cacatgtgcc gtcgatagaa gaagctgagc agacggttca caggctttat 1061521 gaaaaagagc ttctcactga agaacaaaaa gacgctattg atatagaaga aatcgtgcaa 1061581 tttttccata cagaaatcgg cggacagctg atcggtgcta agtggaagga ccgggaaata 1061641 ccattcagct tagcgcttcc ggccaaggag atctatcctg atgcacacga ggcagatgag 1061701 ccgcttttag tgcagggtat tattgactgt ctctatgaaa ctgaggacgg attatatcta 1061761 ttggattata agtcggaccg gattgagggc aaattccagc atggatttga aggagcggcc 1061821 ccgatcttga agaaacgata tgaaacgcaa attcagctgt acacgaaggc agtggagcaa 1061881 attgcaaaaa caaaggtaaa gggatgtgcg ctttatttct ttgacggagg gcacattctg 1061941 acattatagc gagatccata agctccggaa tttcaggcgg agcgggtctc gttttctata 1062001 taaaagagag gtgaaagcat ttgcggattt tacatacggc tgactggcat cttggaaaaa 1062061 cgcttgaagg aagaagcagg ctgagtgaac aggccgatgt gctggatgaa ctgaatacga 1062121 ttgtaaagga tgagcagatc gatgccattg taatggcggg ggatgcattt gacaccgtaa 1062181 acccgccagc tttagccgag cagctgtttt atgaaagcct gtctgcgctt agcgacagag 1062241 gaaagcgccc gatcgtcgtc attgccggaa atcacgataa tcctgaccgt ttgtccgccg 1062301 cttcaccgct gacacatgaa aacggcattc atttaatcgg ttatccgaca acagagccga 1062361 ttcatattga agtgccttca gcaggagagc ttttggcggt tggagcgctg gcgtacccat 1062421 ctgaagcgcg gttaaatgaa gtgctatccg atacgtttga tgaaaagctg ctccgtgatc 1062481 actatgatgt gaaaatcagg caggcgtttg agcatatgac aagccggttc cggaccgatg 1062541 cagtgaagat tgccgccagc catatttatg tggcaggcgg aaaccaaacc gattcagagc 1062601 ggccgattga agtcggcggt gcatacacgg tggctgctga aagcctgccg gcagatgccg 1062661 cttacgttgc gctcggccat ttgcatcgcc cgcaaacgat caagcgggcg cggacgcttg 1062721 cgcgttattc aggatctccg ctcgcctaca gcttttctga agcgggctac gctaaatcag 1062781 tgacgattgt ggacgcaaag cctggggaag aggccacttg gcaagaggtg ttattatcaa 1062841 gcggcaagcc acttgtgaag tggaaagcgg caaatggatt aagtgaggtg tacagctggc 1062901 tggatgaagg cagagatcag aatgcttgga ttgacttgga aatccgtgtc gcggaccagc 1062961 tgtcacttga agagattcac aggctgcgga aggcgcaccc gggctttatc catatcaggc 1063021 cggtttttga agaacagaac aaagaccggg aacggatcga ggttaaacat gtctcaatcg 1063081 aggaccgctt taagaaattt tatgaaaaac aaactggcgg tgcggtgccg gatgaagaaa 1063141 tggtgaagct gtttttagag cttgcatcag gcgttgaaga ggaggatgcg aaatgaagcc 1063201 gatcgcctta agcattaagg ggctccacag ctttagagag gagcagacga tagattttga 1063261 aggcctttcc ggtgccggtg ttttcggcat tttcggcccg acaggaagcg gtaaatcctc 1063321 tatactcgac gcaatgacgc ttgctttata cggaaaggtg gaacgggcgg cgaataatac 1063381 gcacggaatc ttaaatcacg ccgaagatac gctgtctgtg tcctttacct ttgcgcttca 1063441 gacgaatcac caaatctcat acaaagtcga gcgtgtgttt aagagaacgg atgaaatgaa 1063501 ggtaaaaacg gcactttgcc gcttcatcga aatcaaggac gagcatacgg tgctggctga 1063561 taaagccagc gaagtgaata aaagagtgga ggagctctta gggctgacga tcgacgattt 1063621 tacgagagcg gtggtgctgc cccaagggaa atttgctgaa tttctgtctt taaaaggggc 1063681 agagcgcagg catatgcttc agcgtttatt taatttggag caatatggag acaggcttgt 1063741 gaaaaagctg agacggcagg cgcaggaagc caatgcgaga aaaaatgaaa tgcttgctga 1063801 acagtccggt ctcggtgagg cgagctcaga ggcagtggag caggctgaaa aggttctcga 1063861 acaagctgaa gcccggctgg aagcgatgag gaagaaccgt gatcaggcga aggagcggtt 1063921 tacagagcat caggagatat ggaatgtcca aaaggaaaaa tccacttatg aagaagagga 1063981 aaaacgtctc gcagaagaac agccgcatat agacagcatg caaaaacgcc tgctggaagc 1064041 agaaacagca gcagccctta agccctatgc ggaccggtac gcagaagcga tccagcatga 1064101 ggagcaagct gaaaaggaac aaacgctagc ccaaaaggat ttagcagacc ggacagcttt 1064161 ctttcagcaa aaacatgaag agtatgaagc gtggcgccag cataaaagcg agaaagagcc 1064221 tgagctttta gccaaacagg aacagctttc acgcttgcag gaaatcgaaa tcaaactgag 1064281 tgaggccaag caagaggaag agcgcaaaaa ggctgacctc cggcagaaag aagaggctct 1064341 tcaatctgtc atgaatgaat tagagaccgt aacagaccgc ctgacacgag ggcaaaacag 1064401 acagacagaa ttgaagcagc agctcaaatc cctgcaggtg acatccgatg agcgaaaaag 1064461 ctgccagcag gccgcagaga tggcattgcg catcagacaa accgaggaac aaatcaaaaa 1064521 agagaaaaaa cgaagtgaag aattgaacct cgtgctgcag aagatgaatg aagagaagaa 1064581 tacactcgtt caaaagacgg aagcggaaga aaacaacatc attcaggcat atgaggcagt 1064641 tcaaactgtg taccatttgg tgtgcgaaac ggaacgctca ttaacacgta tgacggaaga 1064701 ggctagaaag agtcaacaca cgcttcactt acagcgtgaa aaagcaaggg tggcactgct 1064761 gacaaaagag ttagcccaaa agctgactgc cggaaagcct tgcccggtat gcggttcaac 1064821 cgatcatgat ccatctgcct cggtacatga aacgtatgaa gccgacagcc atcttgaaga 1064881 ggacatcaaa cggacagatg tgttattgac ggaagctgca gctctcagcc aggagattct 1064941 ttcagccaaa attatgcttg aagaacagtc cgcgcgcttt attgaacagt gtccgttttt 1065001 gcagacaatt caagcacaga accttgaagc ggcagcttcc ttcgaacatc agccggtgta 1065061 tgaagcattt gaaactgcca aatttgaatg gaaacgaatc aagcaggaca ttctttctgt 1065121 taagacacga atggcacaaa tgattggcgc ctatcaggag tctttaaaaa aggccgagca 1065181 gcttaatgaa aaaatcggtt ttgaaaaaag agaagccgac cgtattgaaa gcatcatcag 1065241 tgagcttcaa tcctcaatgg acagcagtct gaacatgttt aaagaagcat ttcagaatca 1065301 atctgtggac gaagcagaaa aatggcagca agccattgaa gaaaaggacc gggctgcaga 1065361 agaatgtgaa aaacgaattg agaagagtat cgcgtttctt gctgagcatg aagcacaaaa 1065421 ggaaaaactg cgggaatcgg gacaccggct tgagcgggaa aagctggagc ttcattatgc 1065481 ggctgaacgc atcaagagcg tgatagctga ttatgagcac gaactcggag attatgcaaa 1065541 aggagattcg attcaaatca aactccgctc tgtccagcag gatctaaagc tgttaaagga 1065601 aaaagaacaa tctttatatg aagaactgca aagcgcccaa atgaagctca accaagcgaa 1065661 aagccgcgct tctgcaagcg agctcactct tcaagaggcg aagggcagat tggaaaaagc 1065721 aaaagctgct tggcttgagc atacaaaaaa cacctccatt acccggactg aggaggttga 1065781 acaaagtctc atcccagctg atgaacttga aaagatgaaa accggcatag accagtttat 1065841 ggataaactg aagcaaaatg ctgcaaactt aaaacgagta gcagagatac ttgccggcag 1065901 agcattatca gagagcgaat ggaacgaaac cgttgcagca ttacaagaag ctgaggacgc 1065961 atttggcgct gctatagagg aaaaaggcgc ggccgcaaaa gcactggctg tcattcgcga 1066021 ccatcataaa cggtttaatg aaattgaagc tgaactgaaa aaatggcaga tgcatatcga 1066081 caggctggac aagctgcaag ctgtgtttaa aggcaatacc ttcgtcgaat ttttagctga 1066141 ggagcagctt gaaagcgttg cgagggacgc ctcagcaaga ctcagtatgc tgacaagaca 1066201 gcgctatgcc atcgaagtag attctgaggg cggcttcgtg atgcgggatg acgcgaatgg 1066261 aggcgtacga cgcccggttt ccagtttgtc tggaggagag accttcctca cctcgctttc 1066321 acttgctctt gcgctgtctg cgcagattca gcttcggggg gaatacccgc tgcagttctt 1066381 tttcttagat gaaggcttcg gcacactgga tcaagatctg cttgatacgg ttgtaacggc 1066441 cttggaaaaa cttcagtcag acaacctggc tgtcggtgtc atcagccatg tgcaggaact 1066501 gcgtgcacgg cttccgaaaa agctgatcgt ccatccggct gaaccgagcg gccgcggtac 1066561 gcgggtatca cttgagttga tgtaagggag gagcggatat ggcaaagcag attgccggaa 1066621 tatgtgagct gtgcggccgg agcgatgtcc agctgacaga gcatcatctt acaccgaaag 1066681 aggaaggcgg aacgtttttg ccgacagcga tgctctgtat tccttgtcat aaacagattc 1066741 atgccttata taccaatcaa gagctcgctg tacgtttaaa tggaatggct gaactcagaa 1066801 gcgatccaga gcttgcccgg tttgtcaaat ggatcagaaa acagccgcct gagaagctga 1066861 tcaaaactaa gaaatcaaat gaacgaaaaa agaaaaaatg actaaaaagc agccctctct 1066921 ttgcagagcg gctgctttta tccgtttcca accatatcct gatcgttgac atcggggtct 1066981 atataatttg tcgcgttgac tgcattattt aatagaagga aatctcccgt gtttcctgct 1067041 cccgaaccga gcgcagattt tgaagagctt ttcggagaaa ggtaaaagga atcaccaaag 1067101 tttacgactc cgcccgatat ggaattgata gctataggcc cgacaattgc tggcataaac 1067161 gacacccttt atcgaagtct ctgtttatta tatgttcttg gcgggcgatt gtgagcgcgg 1067221 agactgaatc tgtctgatat gtttgagtct cgcatcaccg cgaataagcg aagctgatcc 1067281 ggcatgtaaa acagaagagg ctgagacccc ttgaattttg atgctgcgaa cataaatagc 1067341 cggcacctcg tggcaaaacg cgctttgtac acctgtttcg gggagcggct tcacggcctg 1067401 ctgctgaaag atctgatact cctttttgtt aaatgagcct tcattatggt aaaacgtgga 1067461 cagagaacgc tgcacagcaa atacttttac actcatatcg atttcatttg tgtcgccaac 1067521 ttgaaacaca cttgcgatcc cgagagaatt aaacttaact agtctgatgc gcgatatgcg 1067581 tttaagcatt attctggcgc aagcggagca aacggcccaa taataagaga ttcaggcggt 1067641 gtatcaaaaa tagaagacag gtagatggat tcagtgtctc cgatgtggaa aacggaggaa 1067701 ctggacacac cgttcatccg aatatccccg acttccaagc tgcggttgat gactgtaaag 1067761 atcatgcttg ctcatctcct ttcatttctg atggaatatg ctccagaaag tgttctacag 1067821 cgcggatgac atcacgcttc acatgctcag cgatatgttc tgcatattgt gcaggcggtg 1067881 tattttcttc ttttttgata tgggacatat aatagtgaat cctgctgtcc atttgttttc 1067941 tgatgtcttc aataacatga tgtctgtttg tatcgtcaag tctgctgtca tattgatttt 1068001 caagctgttc caaaatatct gggatttcct cggttaagta catgtcgaca ttctggcgga 1068061 tctgctgcat gagctgagcg ctctcttcct gctgcatcat cccgatttgc ggtgtcgact 1068121 ggctgacgtc aaagttttgg acgctgttcg ggtcagtcgg atttaaaccg atattcaaag 1068181 tcccgtcgag cctttcgatt ttcagctgat caaatttata ctccacacgc tcaatggtag 1068241 tggccggccg ctgtttcatc gtattcattt cagtttgaat ctctttcagc tgacgttcga 1068301 gctgctgaat gtgaatcgcc tgctgctgaa cgaaggaatt caagttttgc aggtaagagg 1068361 aaacagattg atcatacatg ttcttcacct ctttcatatg attaacggcc aggaggctgg 1068421 agcgggacca atgaacctgt gtcgggctcc tgcagctgga gcggttgccc tgagccagaa 1068481 acttctggtg ccggctctac atagcttcct gtattataca aatttgacag tgacttgatt 1068541 gatccggcgc tcccgatttg cagaatggag gagttgctga ttgattccag ccggagatag 1068601 ttgatttgaa tggtttgatt aatatagaag ttcatgagcc tcactccttt tacgcattgg 1068661 ccacgatcgg ctgatcaacc gcatcattgt catacacatt cgtcgcgttt tgataattca 1068721 tcaccttgag gctgtcgccg gtattaaagc tgccagcacc ggcaaacgtt ctgacctgag 1068781 cctgaggaga aatcgtaatg cagtccccga tgtgaacgac tccgctcgta ccaatcgcat 1068841 taattttaaa cgctccgaca atggccggca tacgagcaca tcctttgttg aaaaattaaa 1068901 aaaagacagg taaagtgaaa tgacaattcc gatttcaatt gggctattca cgatagctta 1068961 tgacaaacgc acatatgtgt gagagaaatt ttaaggggac atatcggctc tttgtgaaag 1069021 cgttttattt tttcgggccg ttatgtttaa acatggcaaa agaggatgtt gggtataaat 1069081 tgagcggaaa tgcggcgaag gatgccgcta tccgcctatg gtgatttttg tttatttctt 1069141 tggtgttttt gcgtgtagaa tgctttttgg agtatgtcgt gctgcggtat tcgatttttg 1069201 ggcgggcaca ttctcgccct gaggtatatc tcagaagtgc tgagcaaaaa tcggagttaa 1069261 atgtggtgta ttctaattgt tatagaaaat gatttacata cgggagtttt caagatatct 1069321 cccaaaaatc atttcttctt taatccgggt attcagcagg atatccagct cttggctgca 1069381 ttgaatcgtt tcttttgaat tcatgccgta tttttgtgcg gtttcaatta gtgtgatcct 1069441 catttcttca attttactgt tcattacgct atctccaatt ctagatttta ttttgatata 1069501 aatacaggat atcgttagta taacctattt tggctcaaaa ggttgccttt cgtcaatttg 1069561 actaaaaaag cgacaatttt tgctgcggcc ttttttaatg gagaaaggac taaagtcttg 1069621 ctaagtgtgc ttgcaaaaag tcctgccgtt cctcaatttc tctaagtatg ttggtctgct 1069681 ccttttcgat ttgaaagggg ctttttttga taaaaggatc atcagcagca ctttgacaaa 1069741 tgtcaaggtg ccattcgttg atgagaggag ataatcgttc aatagtaaac gaccgcttca 1069801 gcacgttttt cattaaggtg tgatattgcg acctgaaggc gggaatggat agaagccttg 1069861 acgaaagcgt ctttcctttt gtcagaagcg ggtcttcttc ataccattct tgtacggcaa 1069921 gcgatcttgt ctccatcggg gaaacgtaaa gccgaccgga ttcgtttaaa caaaatgtgt 1069981 agtaaaagcc ttgattggtg caggtgttgc cgatcagcca caaaaaaaac agcttgacat 1070041 ccagatacaa tttaatcctt tcagccaatt cgtcatctcc ggctgtgcgg atcagtatga 1070101 aaaattcatg taagaatgcc gaggaatcat tgttaaaaag ggacaatgga acccttggat 1070161 cggccgtctt cactccgtaa ctccttttac cggctggctg atggttcttg atgttcaaat 1070221 aaatgccttc aggctggcca ttgatggtca gaaagctgta cgaggcaacg ggagcaggta 1070281 cgccgatctg gtcaaaaaaa caataggcga gtctgcgccg catcagggac ggatcatcct 1070341 gttctgcatt caaaaaaagt gtcctttcac caagcagaga cttttcccag ctgatttcat 1070401 aggatgcctt ttccgctctg tcacgctgtg tgagaagaat gggagaaaca gatcgatctg 1070461 ttacgaaaag ccccttggct gtacctttcc ttttcagctg ctcccgatga aaaaataaat 1070521 gcacgcgctc catattcttt cctccttctc aaaacgacat ttgtatgata tgtagagcaa 1070581 gcccgtcctg aaacgaaatg aaaacggaat tgagaaaaag ggatttcagc attcgacaga 1070641 gaatacatga aggagcattc tgatttaaaa gatgatggag gaataacatg aaatttgcga 1070701 caggggaact ttacaaccga atgtttgtcg gcctgatcat tgacgatgag aaaattatgg 1070761 atttgcagaa ggctgaaaaa aaactgtttg aacttgagac gattccggga tcgctgattg 1070821 aatgtatcgc agaaggggat aaattcgttg cgcatgcaag gcagctggcc gagtgggcaa 1070881 agaaaccgaa tgatgagctg ggatcattta tgtattcatt atctgaggtg aagctccatg 1070941 cacccattcc gaagccatca aaaaatatca tctgcatcgg caaaaactac cgggatcacg 1071001 cgattgaaat ggggagcgag gctgatattc cggagcatcc gatggtattt acaaaatcgc 1071061 cggtaacggt tacggggcat ggtgatatcg taaagagcca tgaagaggtt acctctcagc 1071121 ttgattatga gggagaactt gctgtcgtga tcggaaaaag cgggactcgc atttcaaaag 1071181 aagatgcata tgaccatgtt ttcggatata cgattgtgaa tgatatcacg gcgcgtgatc 1071241 tgcaaaaaag gcataagcag ttttttatcg gaaaaagctt ggatacgaca tgtccgatgg 1071301 ggcccgtgct tgtacataaa tcatctattc aggagccaga gcgcctcaag gttgaaacaa 1071361 gagtcaacgg cgagctgcgc caatccggtt cggcaagcga tatgatcttt tccattccgg 1071421 aattaattga aaccctctca aaggggatga cgcttgaagc gggcgacatt attgccaccg 1071481 gtacgccgtc tggtgtcggc aaggggttta cgcctccaaa attcttgcgg tcaggtgaca 1071541 aaattgatat tacaattgat ccgatcggaa cgctgtcaaa ccaaattggc tgaataaaac 1071601 tggagggcgg acccggaccc gcccgttttt tctgataatc atctttgtga cagaggacaa 1071661 gttcatggta ctataagtgg ggtaatttat ctgatagggg gaacatatat gacacaccta 1071721 catattacga catgggtggt agcgctgatt ctgcttttcg tcagctactc gctgtattcg 1071781 tcaggaagtg caaagggcgc aaaaatcact catatgattc tgcggttatt ctatatcctt 1071841 attattttga caggagctga gctgtttgtc cgtttcgcca actggaacgg agaatacgcc 1071901 ggcaaaatga ttctgggcat tatcaccatc ggcctgatgg aaatgctcct catccgcaag 1071961 aaaaaagaaa aatcaacagg aggcctgtgg gtcggcttcg tcattgtcct tttgctgaca 1072021 gtgctgctcg gtctgcattt gccaattggt tttcaattgt tttaatagaa aaacctatga 1072081 acccggctct ttgatagagc tggttttttt tatatttatc ccctcatatt ccaaatcatt 1072141 taaaataacc ttaaaattcc ctgtaagcgg tatctcgtcc tatgaaatta tgataccttc 1072201 aaggagattc attattttgc aggagggata acatgaaacg cagaaaattc agctcggttg 1072261 tggcggcagt gcttattttt gcactgattt tcagcctttt ttctccggga accaaagctg 1072321 cagcggccgg cgcgatcgat caggcggctg ctctggaaaa cggcaaagag cagacaggcg 1072381 ccatgaagga gccggaacag gtgaaatggt acaaagtgac cccgggagca acggatattc 1072441 agaaaaactc acatatggca ctgaccgtaa agagtgattc agtactgaat gtatctgtat 1072501 atccaagtaa ggaaaaagcg cttaaagatg agacgtttga gatgtaccgt tctttcacag 1072561 cggaggatgg aaaaagcgaa gtcatttttc catacgcgtg gagcggccct tactatgtaa 1072621 aagttgaata cctcggagaa gaagaaccag aggacggcgg aacggcagaa gcagctgcag 1072681 aagccaagta tacgattggg tataaaggca ccaaaaaaca gccgtcagat ttagaagagg 1072741 aagaagcttg tccggttgaa atgagtgtcg atcagaagaa atcaggaaaa ggcatcctgg 1072801 ataagttgag atcgattcgt gatgagcagc tgagccaaac agcagaaggc aaagaactga 1072861 caagccttta ttacaaagca gcaccgttta tcgttgcaaa gctcgcactc aataaaacag 1072921 caagaaatga aatctatcag gatcttgtga cattaaagcc gttatttgac gatgtgtcag 1072981 aaaacggagc atcatcttcg tataaggtca ctgaaaagga tcaaaaagcg atcaaccggc 1073041 tatatgataa agctttacaa tcagtcccgt cattccttaa agaggagata aagaaacaag 1073101 cggaccgact aaatatgaag cagctgcaag gcaaaacagc aggagccatt ttaacagaaa 1073161 acaatattgc agcaaaaagt gaagttcaga caacaaaggt tattttcaag gtgaaggaca 1073221 ataaaagcct ctcatccgta cataatgaaa tgaagggctt ttctgcaagc gcgcaatcga 1073281 aaaaagacat atctaatgtg aaaaaggcaa agaaactgtt tgacaatctg tattcatttg 1073341 aacttccgaa agacgagaaa cagaacggcg catatacggc aagcgccaaa agggtcaaaa 1073401 gcgctgctgc gacactatcc aagatgtcca atgtagagtt tgcggaaccc gtacaggaat 1073461 acaaaagctt ggcaaacgat attcagtacc cttatcaatg gccgcttaaa aacaacggtg 1073521 aaaacggcgg tgtcaaaaat gcggatgtga aatatgagcc tgccaacaca ttgctgtcca 1073581 aacgcaagct taacgataca ctcattgcag tagtagacac aggcgtagac agcacgcttg 1073641 ccgatttaaa aggaaaagta agaacagatc tcggacacaa ttttgtcgga cgaaataaca 1073701 atgcaatgga tgatcagggg catgggacgc atgtcgcagg cattattgca gcccaaagcg 1073761 ataacggcta ttcaatgact ggattgaatg ccaaagcaaa aatcatccct gtaaaagtgc 1073821 ttgattccgc aggttccgga gatactgaac aaattgctct cggcatcaaa tatgctgctg 1073881 acaaaggagc aaaggtgatt aatttaagtt taggcggagg ctacagccgc gtgcttgaat 1073941 ttgctttgaa gtacgcagct gacaaaaatg tcttgattgc cgcagccagc gggaatgatg 1074001 gagaaaatgc cttatcttat cctgcatctt ctaaatatgt gatgtcagtc ggcgcaacga 1074061 atcgcatgga tatgaccgct gatttctcta actatggaaa aggtctggac atctctgctc 1074121 cagggtctga tatcccgagc ttagtgccga acggaaatgt cacgtacatg agcggaacgt 1074181 ctatggcgac gccatatgct gccgccgctg cgggactgct gtttgctcaa aatcctaagc 1074241 taaaaagaac agaagttgag gatatgttga aaaagacggc agatgatatt tcctttgaaa 1074301 gtgtcgatgg cggagaagaa gagttgtatg acgattatgg cgatccgatt gaaattccga 1074361 agacacctgg tgtagactgg cattcaggct acgggcggct gaatgtcatg aaggctgtca 1074421 gcgcagctga tttacagctt aaggtcaaca agctggaaag cactcaaaca gctgtcagag 1074481 gaagcgcgaa ggaaggcacc cttatcgagg tgatgaacgg caaaaagaaa ctcggcagcg 1074541 ccaaagccgg aaaagacaat gcgttcaagg tgaatatcgc gactcaaaaa caggatcaag 1074601 tactgtatct gaaagcaaca aaaggcgatg cgaaaacatc gtataaagtt gttgtcgtca 1074661 aaggaaaacc ttccggcaca ccgaaagtaa acgcggtgaa aacgaaggat acggcagtaa 1074721 aagggaaggc aaacagcaaa gcgatgatca gagtgaaaaa caaatcaaag aaagtcattg 1074781 cttctgccaa agctgacgca aaaggaacgt tttcggtgaa aatcaaaaaa caaaaagccg 1074841 gaacggtgct gtacgtcacg gctgtggata cagataaaaa agaaagcaag gaagcaaaag 1074901 ttgttgttga aaagtaacca aaaagcggtg ctcgatgcac cgctttttta tttgcgcccc 1074961 cgttggactg ctgtgtacat aatggatcgc tttccgtttg aagccgtcca ttcaaaacgg 1075021 tctcctgtcc cttcgctgct gtagttgtag tgatgctgca tcgcgcattg tgcggtgtca 1075081 tttgaaaagt gataaaagga cacaccctgc cccgccgaag tattcgaaaa gactccttta 1075141 ttataagaaa agacgcaatc gaataccgat aagccgaagc tgtgcaagtg ctgcagaaat 1075201 gcgagaaagg tttcgtcgtc aagcgaatcc aaaagcgcca tgagcggccg cttgactgat 1075261 ttctcatagc ggatgcgttc tccgccggaa agggagatgt tttctgcacc gcatgccaaa 1075321 accaacttgt cctgaaagcc ggcttgctcc cactttcctt tatgatggat ccagattggg 1075381 ctgtgttgga gactgtccgc cagcagtata tcgccttcac cgttttcgat taagcagatg 1075441 ccgtcttcaa tgaggatggt gccgtattcc cactttcgtt cctctgtata taacaattgt 1075501 ttccgtttca tccatgctgt ctcctttttc ttcattcctc tcttttcttt ccaattcaag 1075561 cctgtcccat acaactcttt tatggacaaa tcaactatct gcctatagat gcataaactt 1075621 actaaggtgc tgaaagaaac gaaattgtta cgaaagaaac gggattggag ctgatgtcac 1075681 atgtgtggaa ttacgggttg ggtcgatttt aaaaagcagc tcgtccagga aaaacaaacg 1075741 atggacagaa tgacagacac tctttccaaa cgagggcctg atgattcaaa cgtttggggg 1075801 gagcaccatg ttttattcgg acataaaaga cttgcggttg ttgatattga aggcggacgc 1075861 cagccgatgg cgtgtaccta taaaggcgat acgtacacca ttatttacaa tggcgagctt 1075921 tataacacgg aagatttgcg caaagaattg cgggcgcggg gccatcaatt cgagcgtacg 1075981 tcagataccg aggtgcttct gcacagctac atcgagtggc aggaagactg tgtcgaccat 1076041 ctcaatggca tattcgcttt cgctgtgtgg gatgaaaagc gtaatctgtt gtttgccgcg 1076101 agagaccgtc tcggtgtaaa gccgtttttt tacacgaagg aaggctcttc atttctcttc 1076161 gggtcggaaa tcaaagcaat cctcgcgcac cctgatataa aagcgcgagt ggacagaacg 1076221 ggactttctg aaattttcgg tcttggaccg tccagaaccc cgggcactgg catatttaaa 1076281 ggcataaaag aaatccgccc ggctcacgcg ctgacatttt ccaaagacgg acttaatatt 1076341 tggcgttatt ggaatgttga aagcgaaaaa catacggaca gttttgatga cacggttgcc 1076401 aatgtcagat cgttatttca ggacgcggtg acgcggcagc ttgtgtcgga tgtgcctgtt 1076461 tgcacattcc tatcaggcgg tctggactca agcgcgatta cagcgattgc ggcgggccat 1076521 tttgaaaagg aaggaaaagc accgcttcat acttattcga ttgattacga agagaacgat 1076581 aaatattttc aagcaagcgc ttttcagccg aatgatgacg gaccatggat tgaaaaaatg 1076641 acagaggctt tcggcacaac gcaccacaaa tgcgtcatca gccaaaaaga cctcgttgat 1076701 catttggagg aagctgtact ggtcaaagac ttgccgggaa tggcagatgt cgactcatcc 1076761 ctgctgtggt tttgccggga aatcaaaaag gactttgtcg tcagcctatc gggagaatgc 1076821 gcggatgaga ttttcggcgg gtacccgtgg ttccatacgg cagatgttga gtctggcttt 1076881 ccatggatga gatcaacgga ggagcggatc aagctgcttt ctgactcatg gcagaaaaaa 1076941 ttgaatctga aagaatacgt aaatgccaaa tatgaagaaa ccttggcaga aacgccatta 1077001 ttagacggag aaacgggtgt ggataaagca agaagacagc tgttctattt aaatatgctt 1077061 tggtttatga cgaacctttt ggatcggaag gatcgcatga gcatgggggc gagcctggaa 1077121 gtgcgggtgc cgttcgccga tcaccggctt gtggaatatg tttggaatat tccgtgggaa 1077181 atgaaaatgc atgataatcg ggaaaaaggc attttgcgca aagcgcttga gggcattttg 1077241 cctgatgaca ttttgtatcg caaaaaaagc ccatatccga aaacacatca tccggaatat 1077301 acaaaaggcg tcagcgagtg gctgaaaacg atcagaagcc aaaaggactc cgtgctccat 1077361 accttactgg acagaaaaca attagatcag cttttagaaa cggaaggctc ctccttcaag 1077421 gtcccgtggt tcgggcagct catgaagggg cctcagctga tcgcccatct tgctcaaatt 1077481 catacatggt ttgaagcgta tcgcattgat attgacgaga ggtaggttca atacaaatgt 1077541 gattaaaagc cagagatgta tagatttaaa taagaaggat agatgagcag ggaaatatat 1077601 gctctatcta tccttttttg tacaacagca ctatcgaatt gcccccgcat tccttcaata 1077661 agaatgaata ggttttaatg ttctgccgat aaaactagct gataccgggc ttaactttaa 1077721 ttccctagcc catacagaaa gttgaccaat atggtgaatt tcgtgagcga tgatatggtg 1077781 taatatttca tctcgcgtat ataaaacacc tgtctcccaa ggaacgctta caagttcatc 1077841 ttttatttga tctgaatgtg tttgtaaaac atcaattatt tcagttcgga atgtatttga 1077901 gagagatttc actttattga gtgtttgata atcagcgaac tgaacagcga tatcttcttt 1077961 tccttggata gcacgaatcc aactatattc cacatcaata atatgaaaaa gggtatataa 1078021 aatattctct actccgccaa gacgattttt aagtaattct tcagtggtta gttgatgaca 1078081 ccaagtaaac cattgatctc taacctgcca gttatattca aaaaatttca tcactaaact 1078141 cactccaata ctatcatgta tcataacaat tagccctttt ttccgtgatt cctctattaa 1078201 tgaagtgatg attgagaaat gtttacattc tacctgttgt atggcattaa aaataataat 1078261 gcatatctcg tcgatgatgc tgtgcgtctt gttactttta caaagtaaga atcggcattt 1078321 tcttcatata caattaggaa aaaacatact agacttgaag aagcagtgat acataggagt 1078381 gagaaaatga aagagataaa agaagcttac cagcaatgcg gacagattgt tggcgaatac 1078441 gcgccagcct gtttcaaagc attatcatat ctcccgctaa agcaaagaca agcctcttgg 1078501 gcagtattgt cgttttgcca cacggcggcc agtgcagacg aaaaggtatt gcccgcattt 1078561 gaagctaaag ctgatcatgt ttaccaaagg acaaataacg gtaaacaaca tctatggaag 1078621 gcttttgatc atgcgtatcg gacctttaca ttggaaagcg aaccttttcg ggagtttatt 1078681 gccgcacaaa aagaagacgc caagccgtat gatgaccttg atgaactgct catgtacgca 1078741 tatcggacgg gcggtgctgc cggattgatg ctgctgccga tactgacacg ccgaaaacaa 1078801 gatcagctca aacaagcagc cgtctctctc ggcttggcca tacagctggt tcgcttctta 1078861 agtgatcttg gcacagatca gcaaaaaaac cgcattcccc gtcaggtaat gcagcaattc 1078921 ggctatacag aggctgatct ccaaaaaggc accgtaaata aagcgttcac aatgacgtgg 1078981 gagtatatcg cttttgaagc agaagcctac cttgaagagt gtcaggatgc cttgccgcta 1079041 tttccgcagt attctcaaaa aacggtgaaa gccgctcttc atttgcaccg ggctgtttta 1079101 gaaaaaatcc gggcgaagca gcacgatgta tttcaatatc acttcgctct cacagagacc 1079161 gaagtgaagc agattctgtc tgatatctaa aaaacacccg gccttgattg agccgggtgt 1079221 tacgccatac ctttttgaat ccagatacgt gagcgccatc ttctgtacat taagattccc 1079281 cggacccatt catccgcgat aaaagaaatc caaatgccgg caagaccgaa accgaggtgg 1079341 atgccgaaaa gataagcaag cgggaggcca atgccccaca ttgaaatcat tgccatgtaa 1079401 accgggaatt tcgcatcccc cgcggcccgc agagagttaa tgataatgac attaaacgag 1079461 cggcctggtt caaggataat ggtcatggca atcaataggc ttgcagttgc tataatgtca 1079521 gggctttgtg tgaagagtcc gatcaggtct tttgaaaaga tcgtcatcaa aacagaggta 1079581 gccgcagcaa ttccgagtgc ccaatataag ctcttcatgc agcgctcata agcggcatca 1079641 aattgtttgc cgccgatata acggccgatt aagatttgtg taccctggct gatcgcagtg 1079701 ccgaacagca aaataaacat cgtaatattt tgcgtataca cttttgttgt caacgcctgc 1079761 gcgcccatga tggcgataaa atacgtgact atcatttgcg acaggttgta tgaaagctgc 1079821 tctcccgcag aaggaatgcc gattttcagc agcttgcgca aatgctcttt atgcatatga 1079881 aagacttttt tcagcgacat cttcagctgg atgcgtttgt tgacaatcac aatcatcgcg 1079941 attaatccga tgacgcgggc gatagatgtg gacatggcca caccggcaac accgagaaca 1080001 ggaaagccga acaaaccgaa aatcacaaca aagtttccgg caatgtttaa aatgttcatg 1080061 ccgatagtga caaacattgt atcttttgtg tagccgtagc tttttaagat cgcgctgaat 1080121 gtcatgatta aagcctgaat aaaggacaga cctccgacaa cttgtaaaaa gactttcgca 1080181 tcaggcatca gtgcgtctga taatcccatc atatgaagca gagggacagc cgcgaaaaag 1080241 acgacggcgc tgatggccag gctgatgaag aagttggcgc cgattgacac ataagcgact 1080301 tccatggctt ctttcttttg ccgtgagcct agaaattgtg aaatgataac ggtcgttcct 1080361 gttgcgataa agctgaacat cacgataatt aaatttaaaa tctggttgct gacgccgact 1080421 gctgccacgc tgttatccga gtattggctg agcatcagtg tatcggcatt acccataaac 1080481 atatataatg agacctcaat aaagatcggc caagtaagcg aaaataatga gaacgttttg 1080541 tcagcgggtt ttttcaaagc agttgatttg aagacagctt gtttcatcgt gtctaacccc 1080601 tttcgtaaat aaaatcaacg ttttaaagtg tacctccatt tccttataat aaaaagggat 1080661 agaaacgata cttcttgtaa aaatccgact taaaaaggag gatgattcaa atgcctcgca 1080721 tcctgtttac agtcccgcct tttccggtat ttatcgcagc tggggaaggg gtttttaaaa 1080781 aaggagaaac ccatgtgaaa cgtgtattct ccgtgtttga tctgatatat gtcaaacagg 1080841 gaacgttata tataacggaa aatgaaacat cgttttctgt tgaaggcggc gagtacatct 1080901 tgctttctcc cggtcttgaa cactacggga cgaagggcag tgatgaagca acctcctact 1080961 attggcttca cttcgatgaa catcgatatg aatttacggc aaagggaggc agcaactggt 1081021 ctgagcttca gcaggaaaaa gggagcttcg aagagctggc ccgctacgga ttggccttgc 1081081 cgagaaaagg caaggtgcag cgcccgcagt ttatggcgca gcagtttgaa aagctgatcg 1081141 attactccgc ggaaaactct gatttgccgc tcagaaagca aattttattt gaggagctga 1081201 tgctgcatct tcaaaaagaa gcgttccaaa taccgtctgc gaaagagcgg gtagcctggg 1081261 aggcggcccg gtatttacag gagcactata aggaaaagac gacaatcaag gatctgtcgc 1081321 tcgcccttca ctatcatcag gattatgtga gccgctgcat gcagcaggtg ctcggcgtaa 1081381 ctccggcaca atacacgaac cgggtgagaa tgacggaagc gaagcgtctt ttatcctcta 1081441 caaatgataa aatgggcgtt attgcggaaa cggtcggaat ggaagatccg acatactttt 1081501 caaaactctt taagcagata gaaggcattt caccaattga ataccggaaa attgtcagcc 1081561 ggaaagttca ataaccagac gagggatgaa catgaaaaca acaatttacg atgtggcaaa 1081621 ggcggcgggt gtttcgatca caactgtgtc ccgtgtgata aacaatacgg ggagaatcag 1081681 cgataaaaca cggcagaagg tcatgaatgt catgaatgaa atggcataca cgcccaatgt 1081741 ccacgccgcg gcgttaacgg gaaaacgaac gaatatgatc gctctcgtgg cgcctgatat 1081801 ttcaaatccg ttttacggcg aactggccaa aagcattgag gaaagagcgg atgagctcgg 1081861 ttttcaaatg ttgatttgca gcaccgatta cgatccgaaa aaagaaacaa agtatttttc 1081921 tgtgctgaaa cagaaaaagg tggatggcat tatttttgca acagggattg aaagccatga 1081981 cagtatgtct gctttggagg aaatcgccag tgaacaaatt ccgattgcca tgatttctca 1082041 ggataagccg cttcttccga tggatattgt tgtgatagac gacgttcgtg gcggatatga 1082101 ggctgccaag catcttctgt cactcggcca cacgaacatc gcctgcatta tcggagacgg 1082161 gtcaacgaca ggcgaaaaaa atagaatcaa aggcttccgt caggcgatgg aggaagcggg 1082221 cgtgcccatt gatgaatcac ttatcatcca gacgcggttt tccttggaaa gcggcaagga 1082281 agaagcggga aaattgctcg acagaaatgc tccgactgct atttttgcct tcaacgacgt 1082341 attggcttgt gccgccatac aagctgcgag aataagaggc ataaaagtgc cggatgatct 1082401 ttctatcatt ggttttgata atacgatact cgcagaaatg gcggctccgc ccctgacaac 1082461 cgtagcccag ccgataaaag agatggggcg gagcgtcatc gaactgctgg cagaagcaat 1082521 agagggaaaa cgaaaggcga aacaaaaaat agtgctcccg cctgagcttg tagtcagaca 1082581 ttctacatca ccgctcaaca catgagcccg ctaatgagcg ggttttttca ttatgacagt 1082641 tgaagccaaa aaaacatatt gcgtgtaaac caaaggcggt gtaaaatata accatctttt 1082701 gagaaagcgc ttgcgcaaaa tggcagagcg gatagaaccg ctgttttttt agctgttaag 1082761 agaaaacgct ttctcaaagc gagcccgaaa tgagataaag gagaggatgg gacgtggaac 1082821 atcaagtaag atgtgcagta ttgggattag gaaggctcgg ttattatcat gcgaaaaatc 1082881 tcgtcaccag tgtgccgggg gcaaagctgg tttgtgtcgg tgatccgtta aaagggagag 1082941 cggagcaggt tgccagagaa ctcggtatcg aaaaatggtc agaggacccg tatgaagtgt 1083001 tagaagatcc cggcattgat gctgtcatta tcgtaacgcc gacaagcaca catggtgata 1083061 tgatcatcaa agcagccgag aacggcaaac agatctttgt tgaaaaaccg ctgacattaa 1083121 gccttgagga atcaaaagca gcttctgaaa aagttaagga gacaggtgtc atctgccaag 1083181 tcggctttat gagacggttc gatcccgcat acgcagatgc caaacggcgg atcgacgctg 1083241 gagaaatcgg caaacctatc tattataaag gctttacgcg cgaccaaggc gcgcctcccg 1083301 cagaatttat caaacacagc ggtggaattt ttatcgactg ttccatccat gactatgata 1083361 ttgcccgtta tttgctaggg gcggaaatca cttctgtttc aggacacggc aggattctga 1083421 acaatccgtt tatggagcag tatggcgatg tggatcaggc gctgacgtat attgaatttg 1083481 actcgggcgc agcgggggac gtcgaggcaa gcagaacctc tccatacgga catgacatcc 1083541 gggcggaggt gatcgggaca gagggcagta ttttcatagg gacattgaga catcaacatg 1083601 tgaccatcct atcggctaaa gggagcagtt ttgatatcat tccagacttt caaactcgtt 1083661 ttcatgaagc ctactgcttg gagcttcagc atttcgccga gtgtgtccgg aatggaaaaa 1083721 caccgattgt gactgatatt gatgcgacga tcaatttaga agtgggtatc gccgcaacca 1083781 attcctttcg aaacggcatg ccggtacagc tagatgtgaa gcgcgcttat acaggtatgt 1083841 aaaagctaag tatgttgcat ttgaggcttt ccgcaaaaaa agcaagggca ttttagccct 1083901 tgctttctct tttctcatat aaatagtaca tataatcagt aggtacgcct gaatggtcca 1083961 gctgtctcag catggcggtt acgttccctc tgtggtaagt gccgtgattg acgacatgca 1084021 ggatggtgtc tgcataggtt gattccagtg tacctagttt cggatgctgc attgtgaagg 1084081 tctgttctaa gtccgtctgg cggctgaaga aatcatgata ctgtgactcc agctcggcag 1084141 cgtgctgttt aatcgctgcc atattacctt gcgcggactg taatttgcct gcgctgtcta 1084201 taatctcttg gtaggccact cccgaaagaa cattcagcca aatgtagtca gccctgcaca 1084261 tatgaagcag cacgtcgctg acagaaggaa atacgctctt tacttcttga taggcagttt 1084321 cctccggcag gttttcgata tgggtaaata ttttcttgtt tgcccaagaa tgatagtcat 1084381 aaaactgttt tgcatcagtc atcagcatgc ccccttttct aagaaattcg tttttttcat 1084441 ctgtttctcc ttcaattgca aaagagtgac accccaaaat atcctgccgc tgcccacatt 1084501 accgctgcag agcatttgtt tacgatcagc ataagcctgc cgctcgtatc tatcgtctga 1084561 aacaaccggc ccgctattgc aaggctgatg aaccaaatcc aagacacagc gatgcaggcg 1084621 gccataaaga gccatttctc aagccccgaa tattgaagag agctcgtgcc gatgacgccg 1084681 atcgtgtcca gaatggcatg cgggtttaaa agagaaacag cggccgcaaa cgcagcttgc 1084741 ttttttggtg tgaacgtatg tttctcattt tggcttgtgt tcggacggat gttccaagtc 1084801 acccagccca tataaagcaa aaataaaaat ccgccggcca tcatgactgt ctcaaacaca 1084861 ggcagctcct gcacaatgac agacacgccc gcaacggcta atacaattaa caaggtatcg 1084921 cagactgaag cactgatgac agctgggaga gcccgccaaa tatgcttttg caacgcgcct 1084981 tgctgaaaaa taaacacatt ctgcactccc agcggcaaaa ttaagccaaa cgcgagcaca 1085041 attccgtgaa tgattgcatt catgctgaaa aagctccttt cacatttttt ttcaatcata 1085101 agagagattg tcactaaagt ctccagccat ttggttgggt taggaaccag ccaaatgtat 1085161 aatgtgtaaa aaaggggggc atgaccttgt cgcaatggca gccaagccga aagtcggatg 1085221 ttccgctgca tcggcagatc gaacaatata tgaaagacaa gattcttcac ggagagtggg 1085281 ctgtagggac gaaaatcccc tcacagagaa cgctggccga catgtttcaa gtcaaccgca 1085341 gcacagtcac agcagccata gatgaactca cgtctcaagg cttgttagag ggaagaaaag 1085401 gcggcggtac gaaggttgta aacagtactt ggagcgtgct gacggctgag cctccgcttg 1085461 attggagcga ttacgtccgt tcgggcattc atcgcgccaa ttcttccatc attcaagcta 1085521 ttaatcagaa cgaaccaaga gcggatatca tcagattagg aactggagaa ctttcaccgg 1085581 atcttgtgcc tgctgacaca attggacgga tgtttcagca aatcaatccg ggcgtcctgt 1085641 ctttaggata tgagcagccg aaaggaaacc gtcagctgcg ggaggcagtg gccgaccatt 1085701 taaaaggaaa gaagatccat gtgtcaccgt ctgcaatttt aattgtgtcc ggtgcacttc 1085761 aggcacttca gctcatctca attggacttt taaaacgaga ttctgtcatt ttgacggaga 1085821 agccgtccta ccttcaatcc ttgcatgtat ttcaatcagc tgggatgcgg cttcgcggct 1085881 tgccgatgga tgatgaaggg gtcaaagcgg ggcttgtttc ttctaatcga aaacaatatg 1085941 gaggacagct gctttacacg attccgtcgt ttcataatcc gacaggcaca gtcatgtcag 1086001 agcagcgaag gaaagagatc atcagcctgt caaaaaaaga gcagatgccc atcattgagg 1086061 atgatgcgta cggtgattta tggtttgaag aaaaaccgcc gcagccgttg aaagcaatgg 1086121 atcatgaggg caatattctg tatctgggcg cgttttcaaa aacggttagc cccggtctgc 1086181 gaatcggctg gcttgccggt ccggagccgg ttattgaaag gctggcggac attaaaatgc 1086241 agacagacta cggatcaagc ggcctgtccc agtgggcggc tgccgagtgg ctgtcacagg 1086301 gatattatga agagcatctg acttgggtac gcaggaagct taaagaaagg agagacgccg 1086361 ccgttcattt tctcgagcgg tatgccgggg acattgccac gtggcggatt cccgcaggcg 1086421 gcttttatat ttgggtgaca tttcacaaaa acctgcctgt cagccgtttc ttttatgaat 1086481 tgctgaaacg gcaggtgctt gtgaatcccg gctatattta tgacggtgaa gaccgaaaca 1086541 gcatcaggct gtcatattcc tatgcatctc ttggagattt ggaaactggc attaaagcgg 1086601 cagctgaaac agcacgccgc ctgatgatgt cctaggcttt ggttatacga tgacagctcc 1086661 cagtgccctg gcgaaggcaa tcgcgtgctc aggtgcgatt ttgcagcctt tcaatttgtc 1086721 gagggagaca tgaagctgtt caaaacggca cgtgctgatg tccatgtttt gaagggacgt 1086781 gccggtaaag ctggcgcctt ccaattcgca tccgtcaaag tgtgtctgct ggagcaccgt 1086841 atcgctgcat tcactttgca taagagcaca gtgatcaaat cgaacttgtt tcatatttga 1086901 gtacgaaaat gagctgaaat gtccgtggca ttcctcgaat gaaacattcc gcagcgttgc 1086961 ttccgccaca ttcattccaa ccatttttga ctgcttaact gaagttctgt gaatgacagc 1087021 cccgctgaaa tcggcgtttg ataaatcgca tttttcaaag atcacatcgg tcagttcaat 1087081 atgccgaaaa gacacatcga taaagacgac atttctgaat accgtttttt caacacatag 1087141 tctttcgata tcttcgccgc agatggtgca atcttcaaac aaatgcatgc tgattacatc 1087201 atcctgtgtc acggcatcat gaaaatctgc ggtttgcagg ttttccggta tgttcggttt 1087261 ttgaattgcg attttattca tgtgatgaca tcctttgctg cccgaaaaac agaggcttcc 1087321 gggttcaatt taatagatcg ttaaggaaat tgatacatat agtaaatcgt gaagagcctt 1087381 ttcttggtac agcagcccgc ttgttttgta agcataaatg gaaagcttcc tatacgtcaa 1087441 ggcgtttaca ggccgaaaaa gccaaaggga acaggaggaa tgcggaatgg ggcattacat 1087501 caaaaccgag gagcatgtga cactgtttgt agaggatatc ggacatggaa ggccgatcat 1087561 ctttttgcac gggtggccgt tgaatcataa gatgtttgaa tatcaaatga atgagcttcc 1087621 gaaaagggga tttcgtttta tcggcgttga tttgcgggga tatgggcaat ctgaccgccc 1087681 ttgggaaggc tacgattatg acacgatggc cgatgatgtg aaagcagtca tttatacgct 1087741 gcagcttgag aatgcgattc ttgccggttt ttcaatgggc ggcgcaattg caatccgtta 1087801 tatggcaagg catgaaggag ccgatgttga taagctgatt ttactgtctg cggcggcccc 1087861 cgcgtttaca aaacgcccgg gttatccgta cgggatgagg aagcaggata ttgacgatat 1087921 gattgaattg ttcaaagctg atcggcccaa aacactggct gatttaggga aacagttttt 1087981 tgagaaaaaa gtgtctccag agcttaggca gtggtttctc aatctgatgc tggaggcttc 1088041 ctcctacggg acgatccact cgggcatcgc attaagagac gaagatctca gaaaggaact 1088101 tgctgcaatc aaggtgccga cgctgatcct gcacgggaga aaggatagaa ttgcgccgtt 1088161 tgattttgcg aaagaattga agcgcggcat caaacagtcg gaattggttc cgtttgcaaa 1088221 cagcgggcac ggagcatttt atgaggaaaa agagaagatc aacagtttga ttgcgcagtt 1088281 ctccaactca taagaaaaaa cccgacattg atcgggtttt ttatataatt cctctgtttt 1088341 gcagtgcgtt aatgatgaga tcagctccat cggaaataga ggtctggtca gactcaatga 1088401 tgaaatcggg tgaaagcggc gcttcatacg gagaatcgat cccggtgaaa tgtttgatct 1088461 ctccgtttcg cgctttttta taaagccctt ttggatcgcg ctgttcacaa acatgcagcg 1088521 ggcacttcac ataaatttcg aagaactcac ctttaggaaa gagcgctcta accatgtccc 1088581 gatcctctct gaatggagaa ataaaagccg ttaaaatcat ttgcccgctg tcgacaaaca 1088641 gcttcgccac ttctccgatc cggcggatgt tttcaatcct gtcaccagtc tgaaatccaa 1088701 gatctttgtt taagccgtgg cggatattat caccgtcaag cacgtagctc tgaatgccct 1088761 tgcggtaaag cttttcatcg acagcattgg ccagcaccga ttttccggag ccggacaaac 1088821 ctgtaaacca aaggacgcag cttttgtgtc cgtttaagga ctgtctgtca gactttgaga 1088881 tggcagcggg atgccaaatg atgttcggat tgtgtgtcat tgcaattccc cgctgttttg 1088941 cttgatggca acaggctgtt ggtgaagtcc cttgatcagc acggctgcga cctcaggccg 1089001 gctgaattct ttaggcggct ttttgccttg gcggagaagc tctctcactt ttgtgcctga 1089061 taagtggatg tggtctctcg ggctgtgcgg acatgttttg gaggtgccca tgtttccgca 1089121 ttttcggcaa taaaagctgt gctcaaaaaa cagcggcttg atgcccagct cttcctctgt 1089181 gaatgattga aaaatatttt gggcgtcgta tgttccatag tagctgccga cacccgcgtg 1089241 atcacggcct acaataaaat gggtacagcc gtaatttttt cggacgagcg catggaaaat 1089301 cgcttcccgc ggacctgcat aacgcatggc ggcagggaaa accgataaca tgacacgatc 1089361 ctttggataa tagtgattaa gcaaagcctg gtagctctcc attctgatat cgctggggat 1089421 atcgtctgac tttgtttctc cgacaagtgg gtgaagcagc agaccgtcga ccgtttctaa 1089481 cgctgttttt tgaatgtatt catgcgctct gtgaacaggg ttcctggttt gaaagccgac 1089541 aatcgtcttc cagccgagtt tttgaaaggc cgctcttgtt tcagcgggcg ttgcataaaa 1089601 ctgttcgaaa gatttgtcag gcaggctgct gaccgtgata ggccctccga tatagtaatc 1089661 cgggcgcgcc agcaattttt ttacgcctgg gtgggcagga tcgtttgttt taaaaacaga 1089721 cagtgcttct tgtgttttat caggctggta tatatcggtg actgtgatca tgccgtaggt 1089781 aacaccgtct ttcacaagct tgacgtgatc tccggcagac agctgtcttg ctgttttttc 1089841 tccgacaggc agcgtaatcg gcaggctcca cggcaagccg tttgccagcc tcatctcttt 1089901 cacaacggaa tgataatctt tttctcccaa aaaacctgtt aacgggctgt agccgccgat 1089961 cgcaataagc tccagatcac tcagtgcaag ctgatccagc tctgcttggc acgcgcaccc 1090021 ttcaaaatgg catgcgggat cacagcggtt gattaatacc cctccgtggg gttcgtttcc 1090081 attcaacgtg ttcaacctcc atttatacgt ttccttgttt tcttttctgc acttaatgaa 1090141 agtttgacat cagcgcctta acatcatttc gattctcaca tcaagaacct gccatccgct 1090201 attcttgatg caggccgcat tctgttttct cccgtccggc ccatcttcca gccctctcat 1090261 cgttcgggtc cggggaaggc agtgtacaca tttcacagcc tatgctcgga taatgttgat 1090321 cgtgcagttt gttataaggc aaattgtgca ggcggatgta cgtccaaacg tcatcccatg 1090381 tccagtggat aagcgggcaa attttgatga gctcaaactt ctggtccagg tttacgtatt 1090441 gaatatgctt tctcgttggt gactgatccc ggcgcagtcc tgaaatccaa gctgtcatgc 1090501 cggacaggtg ctttttgagc ggttcgattt tccgcaattg gcagcagagg ttcgggttat 1090561 gcttccacag ctctccgccg tacttcgtcc cctgttctgt taagctcagc tcgggttcga 1090621 gcatctggat tgcaaatccc ggatatcgtt ctttgacggt ctcgatcagc tcatatgttt 1090681 cctgaaaatg aagcccggta tccaaaaaga tgatgtgtgc gtttttgttg atttttgata 1090741 ttaagtcgag aagcaccatt ccttctgcgc caaagctgca ggcgtacaca atcttttctc 1090801 cgtacgttcg gtaagcccat ttcaacacat cgagctcatc gatcaattga tccgttatct 1090861 gtttggacag catgtcgttc caagtgtcat atgtgatggt ttcgttcaat gttttccccc 1090921 cgtttgcatc tgcttttttt atctattgat cgagttatag gcagactatt cattttttgc 1090981 ataaaggttc aggttttagg tgccgcgccc gcctaaaatg aggtgcggaa ccattaagag 1091041 cccggctgaa tatgcttttt agcaaaatgg ttttatgccc aaggagaggt agtatgccga 1091101 ttgccattta tcaggggcat catcattcgc ttgccccggc ggacattaac atcgtcattg 1091161 atgtcatcag agcctttacg gtcgcccatt atgcgtttat cggcggggcg aaagagattt 1091221 tgttggtccg gacagctgat gaagcctttg cgctgaaaga cacctatccg gattatgttt 1091281 tgacgggaga ggaaaagggg gtcggtatca gcggatttga tttagataat tctccaaaac 1091341 gtatggctgg gcagaatatg acggataaaa gcctgatcca gaaaacaaca aacggcgtca 1091401 cagcagcatt gggggcgctg aacgcaaagc atctgttcgt aactggattt tccaatgcca 1091461 aaacaacggc acagcatgtg aaaaagctcg tcgcaaacga ttgtgtcata aacatagtgg 1091521 cttcccatcc atccggtgat gacgatatgg catgtgcgga gtatatcaaa ggcatcattg 1091581 aagggacaaa tgtggtaacg gctgcggagg cgattgaaag aataaaaggc tcttctgttg 1091641 cggagaagtt ttttgactgc cgccagccat tgtttgattc ggaagacatc gtttactgta 1091701 caaaagaact gacgggcgat ttcgtgatga aagtgaaaca agatggagaa gttccaacga 1091761 tagagagggt cataatatga atgatttttc actagaattg ccagtgagaa caaacaagcc 1091821 gagagaaacc gggcagtcca ttttaattga taacggctat cccttgcaat ttttcaaaga 1091881 tgcgatagcc ggagcgtccg actatattga ttttgtgaaa ttcggctggg gcacatcatt 1091941 acttacgaaa gatcttgaag aaaaaatcag cacactgaaa gaacatgaca ttacattttt 1092001 ctttggcggc acactgtttg aaaagtacgt aagccagaaa aaagtgaatg aatttcatcg 1092061 gtactgcacc tatttcggct gtgaatatat tgagatttca aacggtacgc tcccgatgac 1092121 aaataaagag aaagcggctt acattgccga tttttctgat gaatttcttg tgctcagtga 1092181 ggtgggcagc aaggatgcgg aattagcaag ccggcaaagc tctgaggaat ggcttgaata 1092241 tatcgttgag gatatggaag cgggcgcgga aaaagtgatt acagaagcca gagaaagcgg 1092301 aacgggaggg atctgttcca gcagcggcga tgtcaggttt caaattgttg acgacatcat 1092361 ttcctcggat attgatatca acaggctgat ttttgaagcg cctaacaaaa cgcttcagca 1092421 agggtttatt caaaaaatcg ggccgaatgt gaatcttgcc aatattccat ttcatgatgc 1092481 catcgcgttg gaaacgctgc gtttagggct aagatccgat accttttttc tgtaaaatag 1092541 cggctgcggg gctctcgtcg tgaagagagc ctctgcctat tattttttat ggcggtacat 1092601 aggcgtgaga tagggaagtg aggtcaggcg gatgttgtag atgaagtcga tgactcttgt 1092661 cgatatcacc tggcatatga gggcttgaat gacgatgccc cagtcaataa tagacgcggt 1092721 gaccataaaa atgatgcaat tcatgatgag caggatcgtt ccaggattcc cgccgcggta 1092781 gatagaaatc atcagagcaa gggctccgaa tcctccgttc gaaattttat atttgtataa 1092841 aagtccgatt ccgagtccca ataacactgc gccgcttgcc agatcaagcc acaggttaga 1092901 tgtgatatca ggaaaaactg catcaaagat caataccgag acagaggtga cggtgataga 1092961 agcgagggtg ccggtgaatg ttctcatctc cagccatttt aaagcggtaa aaagcattga 1093021 tacattcaca gcccacactg aaaatccgtg ggggatttga aacagataat gcaatagcac 1093081 cgcaatacct gctgcaccgc ctgtcggaat atcatgcgga aataaaaaca aggacatgcc 1093141 gagtccttgt agtacgccgc ctacgacaat cataaacgta agttttgctt tcatcagcag 1093201 ttcagccatt aagtcatttg ctcctttatg aaaagacttg tccgctgttt tcattttatg 1093261 aggctgtcca ttatttatgt ctcaaaataa agaaatggcc cagcttaata ggctgagcca 1093321 tcccacttgt agcgattgac gatctccata ttgatctctg tgccaatgcc ttttcctttc 1093381 gggatgtgga ccattccttt tgaaggctgc aggctgacga gatctgtaaa aggattctcc 1093441 atgacgtccc actcgatcgg ttcaatgtga tcgttcttca ttttagacca tgggggcaga 1093501 caggcttgtg caaataaagc atagagccgt gagagcgatc cgtcatatgc atgggcggat 1093561 gctctgacgc cgaaataacg cgcgagctgg aggcagtccc gaaactcatc aattccgttg 1093621 acatgcatga catcgggctg aatgatatcc aaacagcgct gtgaaaggag aggcacatat 1093681 tgcgccgggc ctttcatgtt ttctccgccg gcaacaggaa cagacaaacg gcttcgaagc 1093741 atagcgtaat cctgcggctg atcaaagggc aaaggctcct caagccagcc aatgttcgtc 1093801 cattcggaga aatagcgctc ccatttaaaa gccgcagcgg catcgtagct ttggtttgcg 1093861 tccagaatca tcgtaatgga gctgcctgct gtatgctgca gcgcattgat gtgccggaca 1093921 tcctccttga atgaagtccc gccaattttg actttgattt gctcaaaacc ttttttcaac 1093981 tgggcttcaa cattggagac tgagcggctg atccattgcg gggagtctga gtacgattga 1094041 aaagacgcgt acacaggaat ctcctctctg tatcgcccgc cccataattc gcaaaccgaa 1094101 caatccgcag ctttggctgc aatctctgtc agcgccatgc ttacagcgga ggccgcccgc 1094161 tggtgccatt tttgaatcgt gcgcactaat gacaggcggc tgccagcctg ttttcctaat 1094221 agaaatggga tgatccgctt cgtaaaaccg acatggagag cagggagcca atcaacgcat 1094281 tctccccagc cgtctatccc gctttcggtg ataatcctga tgagataaca agtccgatat 1094341 cgtttaaacc cattggcatc tccgtatggc ttttctaatc gatgaaatag cggaaaggtt 1094401 tcaatccgta caattttcac actgggtgct acctttcctc agcgggctgg agccgattgc 1094461 cagccatttt agggtcttct ttttcttttg tttcttcatt gttttgcttc acatggatga 1094521 gcatcatcac aagaatcccg acaacgagag tcaatcccgc gatgcttaaa aacatgccgg 1094581 gtctggacca ttgcatcagg cggccgaaaa tcggaggacc gatcgctacc cctaagaaac 1094641 gtacagagcc gtacagcgag gtgacaaatc cccgtctttc tttgccgaca gccccggtaa 1094701 tgaaactgtt cacacaagga aggacaagac ctgagcctat actgctcagt acaagaacac 1094761 tgataaaaag gacaagattt tcaatgaatg acagtgccgc gtaggatacg gtcatgaacg 1094821 ccaatccaag tacgatcagc tttttcatta acgattgctt ttgcccgatt ttgcttcctg 1094881 ttgtatagga cgtcacacac ataaccaaaa gcgggatcgc taaaattaag ccttttttca 1094941 cgccgtcggt gtcgtatgtt ttttcaagaa catctgagag ataaaacagg atgccgaata 1095001 aagtaaacaa acaggtcgca ccggctaaat aagcggtaaa cagccatctg ccttcatgtt 1095061 taaagacact taacagccct tttgcatatt gtccgattgg tggcggttct ttttcctttt 1095121 tcttttcttt aataaaaatc caagtcagta cgatcgaaat gatacaaaac acaggaaagg 1095181 caaaaaacgc gccataccag acaagcaggg cgatcagcga gccaatgatc ggcgatagca 1095241 ctttccccat gccgtttgaa gcttcaacaa ggccgagcac cttgctctcc tgggcgcctt 1095301 taaacagatc tcccgtcagt gccatggcaa ttgggccggt tccggctgcc ccgattccct 1095361 gtaacgctcg tcctgccatg acccaaggat aggcattgtc aaaaaaacct gccgcaaacc 1095421 cggctaacaa accgccggca ccatacaaaa ttaagcaggg aataatgatg actttccttg 1095481 agaatcggtc tgcgagataa ccgacaatcg gaatcgcaaa tgctgcaatc aaggaaaata 1095541 ctgtgatcac gagactgact tgaaattgtg ataaatgaag ttcagatttc atttttggca 1095601 aaatcggaat aagcatcgag tttcctaggg ttaatattaa agggattgaa ccgattgcca 1095661 caatcgtcat tccgttattt tgttttgatg attccatctc agagcacact ccttttcttc 1095721 tgcttagaat gtccctgatg gcttcgttta ttcagcgatc agacagcaaa aaaccgaaca 1095781 gaagatacct gttcgggaaa aaagagggtt aaccgagagc ctgtgaaatc aaagcatata 1095841 agtgtccatt ttgaataggc gcttttttct gatagaacaa aatcggaggt tcatcatctt 1095901 tatgaaatcc catttctatc aggctgtcat gcagagacgt gtgttcactc ggtatatcga 1095961 ttcgcatcgg cccttgtttg ccggccgcca gccttgtaat tatctgtgct gcaacatctg 1096021 atgatggagc gatgataggg ccgaatttca aattggccgg tgtctgtaca gaaagtccgt 1096081 agccaatgag ctgtccgtcc tgatttctgg cgatgataca ttcgcatgaa gcagaaataa 1096141 gctgctgcaa aaggtttgat cgatctccgc caaaggcagc cagatccgcc gcggttaagt 1096201 cgtgaaagtc ttgttctcta aaggatgtca gttcagcatc aagctttttt gtataaggtt 1096261 gaaaactgtg acagctgtac tttcgcactg aacctgccgt atgaaaacct gctttttcat 1096321 aaagcggcaa accttctttt gtggcgcaaa gcctgatggc ggtgttttca tccgtttggg 1096381 taatacaggc gtttaccata cgccggccaa gaccgagccg ttgatattcc ttgtcaacga 1096441 taacaaggcc gatagaagta agacggccaa acaaaaacaa gccgatgcag gaaataatat 1096501 caccgctgac attttgataa ccgaaaaagc gtccctgctg aacaagcagt ttcagctctt 1096561 gttcgccata atccggccac ccggcttgcc cgcaaagccg caataagccg gaaacgtgtt 1096621 cttcatgaag cttaatcagt tcatctacta cgtccataag atcacctgct tgttctaagt 1096681 gttttgtaca tgacaatatg attgccaatg ccgggaatgt caaatggttc gccaagttcc 1096741 ttccagccaa gcttggcata gtagcccttg acatggtgtc ttgcgttgca ccataccgcc 1096801 tgaacgccgc tctccgccag tttgtgctcc gcgtgtttga tcagcgtgct tccagctttt 1096861 tgatcgcgat atccctcgag cgttgccatg cctctcagcc gatacgcaga ggcttccgtt 1096921 aataaaggct gactttgcgg ggaaaaagaa gcgatgctga tcagcgttcc atcataaaac 1096981 acgccgagat gaaaggagcc ttctgcgtga tcctctttat atttgcattg ttcgatggat 1097041 tgatggggac gcagaatgcg atgccggatt tcatatgtat cttccacgga aatggttttg 1097101 acttcgagca taatgttcct cctcatgatt gtttttctat atcgtaacac gaatctcgtt 1097161 gaaaaagact gcccgattcg atcaggcagt cttttggaaa ttaatgcaaa aagatatttt 1097221 ggcgctgctc atctttttgc tgaatatatg atgtgagctc agcggttaag tcagatctga 1097281 ggaaaggcgt tatcaagtag atgccgttaa acagctcgca tgccgtatcc agcagggagc 1097341 gtgcaattgc aaggccttcc gccttttgct tttctttatc ttcaccggca tgggccattt 1097401 tttcgcgaat cgtatcagac agcttaatgc cgggaatttc attatggatg aattcggcat 1097461 tccggctgct tgtcagcggc atgatgccga tatagatcgg cgtcttcaga tgttttgttt 1097521 cgttatggat atcgacaagc tgctgctcgg aatagacagg ctgagaaaca aaataatctg 1097581 cgccgcaatc tatttttttc tcaagccgtt ttaccgcttt atccagatgg cggacgttag 1097641 gattaaatgc ggcggcaact gagaaattcg ttttcttgcc gagcggtttt ccagacagag 1097701 acagaccttc attgaattgt ttgatcagcc tgattaaatc aaaagatgtt aaatcatata 1097761 cagacgtcgc cccaggaaaa tccccgattt tagaagggtc acctgtaata gcaagcacgt 1097821 cattcagccc taacgtatca aggcccatta aatgtgactg taagccgata atgttacggt 1097881 cacggcacgt aatatggaca agggaacgca tatcgagctg ctgcttgaca agggcgccgc 1097941 aggcaacatt gctgatccgc ggggtcgcca aagaattgtc ggcgagtgtc agggcatcga 1098001 ttcccgcttc ttttaattca gcagcagcgg acagaaattt gtcaaagctt agttttttcg 1098061 gcgggtccag ctctacgata atagagcgtt ttttcgctgc gatctcatcc aggccgggct 1098121 cggttcgctc gtgatgaaca gaaatgaatt ctttcgcccg ggttttgact tctttttccg 1098181 taatcggagc cagcccgcca accgcttccg ccatcgccct gatgtgattc ggcgttgtgc 1098241 cgcagcagcc gccgataatc cgcgcacctt gcttacggaa ttctgacgcg ctgttttgaa 1098301 aatacgtgtc gtctgtttca tagacgagcc gtccctcttc aagcgaagga agactgctgt 1098361 tcggataaac ggataagaat acgtcatcaa aaatcggcac ttcgcttagc gcttcaatca 1098421 tgtgataagg gccgaggcgg cagttaatgc cgacaatatc agctccgaga tccgcaatcg 1098481 agcgcaatgc gtcagaaagc ggcgttccgt cctgcaatac gccttgctcg tgcatggaga 1098541 cattgagcat aatcggaaga tcagtctctt tgcgcgcgat tttcagcact tcacgggctt 1098601 cttccaaatc ataatatgtt tctaacagca agccatccgg ctcttcatgc agcagcagat 1098661 acagctgctc gcggaagctg cgcttaattt cgtcaagact gtatgcgttt ttattaaatg 1098721 tgcgtatgcc gcccatcgtt ccaagcacgt atgcatcgcc tgctgaagcc cgcgcgatct 1098781 ttacggcctc ctgattcatt tttttgatgt catcctcaag cccgtgtctg gataatttaa 1098841 tatagttggc tccgtacgta ttcgtttgaa taatgttggc tcccgcttca acgtacgctt 1098901 tatgtatgcg ctgaatttcc tccggctttg aaatattgag ctcctcaaaa cacctgtcaa 1098961 tgccatagga gtagaggagc gtccccatgg cgccgtcacc gattaacacc tgtctttgca 1099021 aatcttctaa aagtcccatt gtctgcctcc tttattcaca tcagcaagga aaaaagagaa 1099081 ataaaaaaag tcctcttaag aagaagactt tgtcagtgat tttgtctctt cttatcttcc 1099141 aagctgttcg agcttgctgg atttagcacc ttggtcatgg ctgatcgcca ttacaccggt 1099201 tgctgaagct tcgtcgggcc agtccctctg cttctcttga taagaacgga tatgaaattt 1099261 tcgtgtcagg aagtgccaaa agatatctgg cgtttttccc tttctccaaa tttaccgaaa 1099321 ataaagacaa taatcaatag gaatcagaaa atttatctga aatttataaa ttgaacgtca 1099381 attggcagat ctgctccccg tacagctgag ataatctgct gcaggtcatc tttgtttttt 1099441 ccggtgacac gcacttgatc atcctgcacc tgagacttta ctttcagtcc ggagtttttg 1099501 atgatcgtat tgattttttt tgcgttgtcc ttgtcaatgc cttgaacaag ctttgcacgc 1099561 tggcgcaccg ttccgcctga cgcgttttca accttgccgt aatcaatgtt ttttgtcggt 1099621 acgtttcgtt taatcaattt gctgaccagc acatctttca gctggcttaa tttgaattcg 1099681 tcatcggaaa cgaggaccag ctcctcttta tctaaagaaa tgtcgctttt gctgccttta 1099741 aagtcatatc gggtactgat ttccttcagt gcgatttgga ttgcgttttg cacttcaggc 1099801 aattccacct tggatacaat atcaaatgaa ctttcttttg ccatatgaaa acctccataa 1099861 catttaactt atgtgttgat tatagtagaa taaagagaaa cttccaacag aacaaagaat 1099921 caatttgtga tgattggaaa aaatgttaac aaaatccgca gagaataagc ggaacaggaa 1099981 ggacgatagc atgagaccag ggcagcaatt aaccttgagt atagatcacc aaaccgactt 1100041 cggttacttt ttaaccgatg gggaagatac gattctctta cataacagtg aaatgactga 1100101 ggatatcgag gacagagacg aagtagaagt ctttatatac gtagaccagc aggaaaggct 1100161 tgcggccacg atgaaaattc cgatcatcag cgcggatgaa tatggctggg ttgaagtggt 1100221 ggataaagtg gaagatatgg gcgttttcgt tgatgtcggt ttatcgaagg acgcactagt 1100281 cgcaactgag catttgccgc cgtacgaaga tgtctggccg caaaaagggg acaaacttta 1100341 ctgtatgctg aaggtgacga accgggggcg catgtttgcg aaaccagcgc cggaagatat 1100401 catcagcgaa ctgtttaccg acgcttcaga agatctgatg aataaagagc tgacaggtac 1100461 ggtgtacagg ctgatcgcat cgggttcatt cgtgatcacg gatgacggta tccgctgttt 1100521 tattcacccg tcagaaagaa aagaggagcc aagactgggt tcaagagtca caggccgggt 1100581 gattcaagtg aaagaagacg gttcagtcaa cttgtcgctg cttccgagaa aacaggatgc 1100641 aatgtcagtt gatgctgagt gcattctaac gtatatgaga atgagaaacg gtgccatgcc 1100701 gtacagtgac aaaagccagc ctgacgatat cagagaacgt tttaatatga gcaaagccgc 1100761 ctttaaacgc gcgctgggcc atttgatgaa aaacggaaaa gtgtatcagg aaaatggatg 1100821 gacatacgag aaaaaatagc atgaaaacgg ctcgcctgca gcagactgcg gagcgagccg 1100881 tttttttatg tctagtttaa ttcatcaacc agcgttctga ttgccatttc gcgatccaca 1100941 ttgtctgaaa tcgcaatcgg cgtaatatca atggcgagaa tgatcagaat cagggcacct 1101001 gctgcagcaa cataagaaac ataatagaaa tagttagcgg tatcaacagt gttgacaagc 1101061 tcggcctgaa ctctggatgt atcatcctta gaagcggcga tttcctttgc agcttctact 1101121 ttttcttcaa cgatttgacc tgcttttttc agcagttcat ccactttcaa tgcatctttg 1101181 ctgtaaacag ctttcttcag gttatcaaaa aagtcagcat cctctttttt aatatcagcg 1101241 acaacctgat tggcaaaagc ctttgcctgt tttgtgttga gtttgtctgt catcgcttta 1101301 ttaaagacct ctggaagctg tttgccaact tccccttggg caaacacaaa gcctttaaaa 1101361 atttcctcac ctgaatactc aagctgcttt gcctgtgcca cactttcttg ctgcttcacc 1101421 aaaaacacag tcgtcaccaa tacaaccgac aaaaatacta gaaacgcctt cttcaaactg 1101481 aaacctctcc cttcttgtgt tttttattcc acaacagtct gcgaatatat gtaaattgaa 1101541 tcgtggaatc gataggagtg agatacaata tcaaaatgcc ggccatgata atcgaaaaac 1101601 tgatgaggcc cagcatgact gcaaaaatct catgcataaa aacagcgatg atcaaaatca 1101661 atctccaatg cttcttcggc gcaaacagtg ccgcgaagat gacaatttga accagcagcg 1101721 tcccccatgt cggaatcacc acgaacggac ttgttacaat tggcttcgtt aacgcctgaa 1101781 aaaagccgtt gaagccaatg gttttttcct gggcgaaata atagacggcc gttccgtcca 1101841 cccattcctg ctgagatagc ttagcgacgg tagagtgaaa ataaagcacc gccacttgga 1101901 ttctgatcac aaaataagaa ataaaagctg ttatttttcc aagtgttctt ttgccctcta 1101961 taggtctcgt actccaatgc cattttctcg gatcggtcag cgtgatggga agcaataaaa 1102021 aggtcatgac tgctgctgcc tgctcgcctc cgtcgatgac gatcagcgat gactgcaggc 1102081 tgtaactgac ataccaatgc agaaccccgg tgattctggg gcgccagcca atgacaacaa 1102141 gcaccagaat ggcaatgcag acccatctga aaagatttaa catcatatag ttattttcgc 1102201 cgagacaaaa gagactgaga ttcattttac aagctggata gctgctgatc ccgctggctg 1102261 gcttcataat gaggctcggg tgattgatga gcagcgtcag caggctggat agcgcaatga 1102321 tgcttcgcgc gaggccatat acatttgtcc acgggtttct ttcgtcccat ctggtgatgg 1102381 tctgttttat gttttcgagc atgagatcac aaccttgact atgcttttta cctgataaga 1102441 cgaaggggta tatttagaat agctccaagg aacaatatcc tctttcgtca aatagtagct 1102501 gccacaaagc agcgggcggg gagcgggtgt ttttaattgc acggttttgg ctttgctttt 1102561 gcatgcgccg aggtcctttt ctttacatgc tgtccactgt tccttgccga cttggctgta 1102621 gatcacgccc atttcaacgc cttgtgaccg cccataccga tacaggccga ataggttgtc 1102681 agccctcata ttgggccatc tgaccttggc gctggcattt tcagcctcat ataagccgat 1102741 tgcagtatca cgcggatttt tgctaaaaaa gccccagccc tgagggagga tgctggacat 1102801 gagaaatttg gagtcctttg tcagcggaat cggggttgtc cctaagctgc caataataga 1102861 aaacagaaat agcgaacccc aaaggattga aaaaatgaca aaaaatgata tcgatttctg 1102921 cattcgactg ctccttttaa cctgaagaat cgtttttaca cttttcataa tataaaaaca 1102981 tttatgtaat aaaaaggtta aaaagtatga gaaattccat ttttgttaaa aggaaaaaca 1103041 ggacatttta cactgctata tgtgattgat atatagtgtt tttttcgata tatttaaacc 1103101 atgaaaacga atcaagttaa tgaccgctgg attgttcaat ttcgaaaagg gattttcgag 1103161 ctggccatcc tatcccttct gcgttctaaa ccgatgtacg gttatgagct gacgtcatcc 1103221 ttaaaaacca cctcggcgct ggctatttca gagggagcga tttatccgat tttgaaacgt 1103281 atgaccgaga agggatggat cgaatttttt tgggaagatt cactggacgg cccgaaaaga 1103341 aagtattaca aaatgacgca aaaaggagaa gaaatgttaa aagaacggct ggagaaatac 1103401 ctggaaaccc atcaagcctt actgtcttta tcgggggatt tgctatgaat ggacagctta 1103461 tcattgaccg atacatggag gaactaaatg cagagctggc gaatatgcct gatgtagaga 1103521 gagaaaacgc tatcgacgaa ttaaaggggc atatcaccgc tttcgttcaa gacagaatca 1103581 aagccggcct tagtgaagag gaactgcagg aagctgttga atctgaattt tctcatccga 1103641 aggagcttgc cgaattgatg atgggtgatg ggggagagac gaaaaggagg aggtctttat 1103701 tgggcaaaag ctggatttcg gtccttctca ttgtcacgat tatcgccctg ccgctgctgc 1103761 cgtccgactt cagacatctg ccgctggctg tttatttaat ggtgctcgcc ggatatgtat 1103821 ggaagcggaa aaaattggtg atgtttgcag gtgtcagaaa aaacaaaatg cgctctcaaa 1103881 aggagattgt caagatttcg cgagtcggtg cggtttatct gctgttttta gcagtggtgc 1103941 tccttttgag cccgttcctc aatgcgcttg tcgtcctgct gctgattgca gtaagctgcg 1104001 ccgctttttt tctttttctt aacatcaagt aatcttgtag gaggctgtaa gatggaaatc 1104061 agcatcaatt atctattaat tgtcatcgcg cttttattct ttgtggttgc ctattttgtc 1104121 ggaatcaaaa aacaaacctg gatgttggct gggtttaacg aggcgcgtat acgggataaa 1104181 gatcggctgg ccagaatagc aggctacttt ttcttgaatt ccggtttgtt cattttgctg 1104241 aatagtttta tctcatttca aggtcaggag cagctcatac ctccgcttat actggcatat 1104301 ggagcagggg ttattattta tgtcaataaa aaattagtag agtagaaaaa gaagggcaga 1104361 gcgaaatatc tctgcccttc ttttttggga aaataagaac gaagcaccac atacaagttt 1104421 ttgtattttt gataggatga agaaaaatgg tagattccaa aataggaagg atgtggtgtt 1104481 ttgcgcaact tgaccaagac atctctatta ctggccggct tatgcacagc ggcccaaatg 1104541 gtttttgtaa cacatgcctc agctgaagaa agcatcgaat acgaccatac gtatcaaacc 1104601 ccttcataca tcatcgaaaa gtcaccgcag aagccggtac aaaacacaac ccagaaagaa 1104661 tcgctatttt cctatcttga caagcatcaa acgcagttta agctcaaagg gaatgcgaac 1104721 agccattttc gcgtttcgaa aaccataaag gatccaaaga caaaacaaac gttttttaaa 1104781 ttaacggagg tttacaaagg aattccgatt tacggctttg aacaagcggt cgcgatgaag 1104841 gaaaacaaac aagtgaaaag tttctttgga aaggtgcatc cgcaaatcaa ggacgtctcc 1104901 gtcacaccgt ctatttctga gaaaaaagca atacatacag caaggcgtga gctcgaggct 1104961 tccattggaa aaatcgaata tcttgatggg gaaccaaaag gcgaattata tatctatcca 1105021 cacgacggtg aatatgatct cgcctacctt gtgagactct cgacatctga acctgagcct 1105081 ggctattggc attatttcat cgatgccaaa aacggaaagg tcatcgagtc ctttaatgcc 1105141 attcatgaag cggcaggtac aggaatcggc gtgtcaggtg atgaaaaaag ctttgacgtc 1105201 acagaacaaa atgggcgctt ttatttggct gacgaaacaa ggggaaaagg gatcaataca 1105261 tttgacgcga agaacctgaa cgaaaccttg tttacgcttt tgtctcaact gatcgggtat 1105321 acgggcaaag aaatagtcag cggcacgtcc gtatttaatg aacctgcggc tgtagacgca 1105381 cacgcaaatg cgcaagccgt ttacgattat tacagcaaga catttggccg tgattctttt 1105441 gatcaaaacg gagcaaggat tacgtctacc gtgcatgtcg gcaaacaatg gaacaatgct 1105501 gcgtggaacg gtgtccagat ggtatacggg gatggagacg gttcgaaatt taagccgctg 1105561 tctggatcgc tcgacattgt cgcgcatgaa atcacacacg cagtcacaca gtattccgcc 1105621 ggtcttttat atcaaggaga acccggtgca ttaaatgagt ccatttctga cattatgggc 1105681 gcgatggctg accgtgatga ttgggagatc ggcgaagatg tctatactcc tggtattgca 1105741 ggagattcat tgcggtcatt ggaggaccca tctaagcagg gaaatccaga tcattactcg 1105801 aaccgctaca caggaacaga ggattatggc ggagtccata tcaattcgtc cattcacaat 1105861 aaagcagctt atcttcttgc agaaggaggc gtgcaccacg gtgtacaggt tgaagggatt 1105921 gggcgtgaag caagtgaaca aatttactat cgggctttaa catattatgt aacggcatct 1105981 acagatttca gcatgatgaa gcaagcggcg attgaagctg ccaatgattt atacggtgaa 1106041 ggctcgaagc aatcagcttc agtcgaaaag gcgtatgagg ctgtcggcat tctatgagca 1106101 aacaaaaaca gtcaggacac agagtctgac tgtttttgtt tgctcatttt cttaaaaaga 1106161 atatcgccaa tgtacctgga ccggcatgcg agccgatggc tgaactgatt ggatgcataa 1106221 tgatttcttt cggcttgaac gcttcctcaa tcaggtgttt catatccgtg gctttttctt 1106281 tgttcgcggc gtagctaatc ccgacggttt gattgctcca atcatccccg cgctctttca 1106341 taagctcgat gatccgtttg aaaagtttct tctgtccgcg aattttttcc agaggcacaa 1106401 gcttgccgtc ctccatctga agcagcggtt taatattcaa caggccgccg acaaaagcgg 1106461 acgttttgga tatccggccg cccctcgcga gatatgttaa atcatcaacg gtaaaaatgt 1106521 gttcaagctg gctgcaaaag ttctttacag acgtttcaat ttcttgtatt gtattcccgt 1106581 tgatacagag atcggcagca tgccggacag ccagaccgta tcctaatgaa gcgcatttgg 1106641 aatcaatgac ccgcaaatcg aaatcgggga attcctcctt cacttcattg gcgatcatta 1106701 cagctgtctg atacgtgccg gagagacctg aggaaaaggc aatgtaaaga gcgggatcac 1106761 ctgtttcggc atattgcaaa aacacatttt taatcgtttg cggtgaggct tgggacgtct 1106821 taggcgtttc tccattttgc atcgcttcaa atatttgatc cgcatgaatt gtgactgcat 1106881 cttcgaattc tttatcgccg agagaaaccc tgagcggaat aaagccaatg cctttttctt 1106941 caaaataaga acgaggcaaa tcagtggcgc tgtcagcgat gagatgaact gtcatattgc 1107001 ttcccttctt tccgttatcg ctcgttatca tgagagttaa gccaactata tcatattaat 1107061 ttgccaaaat cgtgttcaaa tatttgtttt aagggaaaac ataataaaga agaaagagcg 1107121 gaggaacatg ccatggtact agatcaaaca aaaaaattac tcatcgtcat catcggcgct 1107181 ttactcaatg ctgccgggct gaacttattt ttgatacctg cagatgtata tgccagcgga 1107241 tttacaggtg ttgcccagct tttatcaagc gtcgttgatc aatatgcccc cttttacata 1107301 tcgacgggaa cgctcttgtt cctcttaaac attccggtcg gtattttagg atggctgaag 1107361 gtcggcaaat cgtttacagt gtacagcatt ttaagtgtcg cactcactac tctgtttatg 1107421 gggatcctgc cggaaacaag cctgtcacat gacattttgc tgaacgcggt gttcggcggc 1107481 gtcatttccg cagtcggtat cggcttaaca ttaaaatacg gagcttcgac aggcgggctt 1107541 gatatcgtcg ccatggtact tgcaaagtgg aaggataaac ccgtcggcac gtatttcttc 1107601 attctgaacg ggattatcat cttgacggca ggattattgc aaggttggga gaaagcatta 1107661 tataccctgg ttacactata tgtgacaacg agggtgatcg acgccattca cactcgccac 1107721 atgaagctta cggcaatgat tgtgacgaaa aaagcggacg aaatcaagga agccatttac 1107781 ggaaaaatgg tgcgcggcat cacaactgtt ccggcaaaag gagcatttac gaacgaacag 1107841 aaagaaatga tgattatcgt catcacgagg tatgaactgt acgatttaga aaagatcgtc 1107901 aaagaagttg atccaaaagc atttacgaac atcgttcaaa cgacagggat ttttggtttc 1107961 tttagaaaag actgacgaaa gcaggtggaa gtcgtgaaac ggctgcttgt gatgctcctc 1108021 cccgtgctgc ttttgatagg ctgcgggaaa gatgagcaga cagaacccga taaggaggta 1108081 tcaggcggaa tggagaatca agaggttgtt ttatctattg acgcaattca ggagcctgaa 1108141 caaatcaagt ttaacatgtc gctgaagaac caaagcgaac gtgctattga gtttcaattc 1108201 agcacagggc aaaaatttga acttgtcgtg tatgattctg agcacaaaga aagataccgt 1108261 tattcgaaag aaaaaatgtt tacgcaggct tttcaaaacc tgacgcttga atctggagaa 1108321 acatatgatt tctctgatgt gtggaaggaa gtccctgagc ccggaaccta tgaggtaaag 1108381 gtgacattta agggcagggc ggaaaatctc aagcaggttc aggctgttca gcagtttgaa 1108441 gtcaaataag aggctatggc gagtcgccat agcctttttt tattgcagtt tgtccagctg 1108501 attttgaaat tgatgcaact gttgacgttc cgcatctgtc gaattggcat acgcagaaga 1108561 tacagcattt ttggctctca gaatcgcttg ctcctgatcg ccttcctcaa agccgtttgt 1108621 caccatgacc gcctgttgaa caaatgattt tgcctgctga aacagttcat ttctcattta 1108681 atattcatac tgcctttcag ccgagtctcg tgccgcggca tgctggtgag cttcttctaa 1108741 agtagaccga tatggaaatc ttgcggcgtg tagcccgatg gagtctttac cctgctgaat 1108801 aaaccttctg gatttgcttc gtttacccat tttgagactg cccccttcca tactttgacg 1108861 agatgagtcg tcttcaatag tatggtgggg taaagtaagg tttatgagtg ggaaaaatta 1108921 atacggacct tctttaaagt gagaaatatt ctttcaaaaa ccttgccacg ccgtcctctt 1108981 catttgtggc cgtagttcgg ttggcaatct gcttgaccgc gtcaattcca tttcccattg 1109041 caacgccgca gcctgcaaat tcaagcattt ccaaatcgtt atcctcatct ccaaaagcaa 1109101 tgatccgctc cctcggcacg ccgtaataat cgctgatttt ctgcaggccg accgctttat 1109161 tcatgccgct tttgataatt tcaatgacat gccaaggagc ggcccatctt ctatggtcga 1109221 tcacctcggc atgcacatcc gataaatatg agcgtattgc cggcacatcc tcttcctttg 1109281 catgtatgag tacggacgtc acatcttcac cgagattttc ccgcaagtct ccgaccgtta 1109341 catttgttgt gttcatgtta aaggcatcta tcaggtgctc atcatggtaa tgaaagtata 1109401 cgtcgtcaat cacttcagca agcacgttat gtacgttgta gctctcgctg atatccacga 1109461 gctgtttgac aacatcaagc ggcagtgacg tatgataccg tccccagctg tcgtcttgcg 1109521 gatgatggac aaatgctccg ttaaaattga caattggcgt tgtcagctcc atctgctggt 1109581 agtacatgga acttgaacga tacggacggc ctgttgagat gcagacataa tgcccgtcat 1109641 cttttaggcg ctgtatcgta tgaagggtgt tttcagatat ggttttatca tcctttaata 1109701 atgttccatc taaatctaat gcgattaaat agggttttgt ctccatgaaa agctccttta 1109761 accttagatt ttgcttgttt tgccttactt acagtgtagc tttttaccat ctttattgtc 1109821 tacatgttac acttatgatt atggttatcc taaggagggg cacattgtga tacaaattga 1109881 gaatcaaacc gtttccggta ttccgttttt acatattgta aaggaagaga acaggcaccg 1109941 cgctgttcct ctcgtgatct ttatacatgg ttttacaagc gcgaaggaac acaaccttca 1110001 tattgcttat ctgcttgcgg agaagggttt tagagccgtt ctgccggagg ctttgcacca 1110061 tggggaacgg ggagaagaaa tggctgttga agagctggcg gggcattttt gggatatcgt 1110121 cctcaacgag attgaagaga tcggcgtact taaaaaccat tttgaaaaag agggcctgat 1110181 agacggcggc cgcatcggtc tcgcaggcac gtcaatgggc ggcatcacaa cgcttggcgc 1110241 tttgactgca tatgattgga taaaagccgg cgtcagcctg atgggaagcc cgaattacgt 1110301 ggagctgttt cagcagcaga ttgaccatat tcaatctcag ggcattgaaa tcgatgtgcc 1110361 ggaagagaag gtacagcagc tgatgaaacg tctcgagttg cgggatctca gccttcagcc 1110421 ggagaaactg caacagcgcc cgcttttatt ttggcacggc gcaaaagata aagttgtgcc 1110481 ttacgcgccg acccggaaat tttatgacac gattaaatcc cattacagcg agcagccgga 1110541 acgcctgcaa tttatcggag atgaaaacgc tgaccataaa gtcccgcggg cagctgtgtt 1110601 aaaaacgatt gaatggtttg aaacgtactt ataaagcact aagttattaa caagagctga 1110661 atttacgtta tactgtagaa aaaaggagtg agggaacgtg gaagaagcat taaaagaaaa 1110721 catcatgggc gccctggaac aggttgtcga tcctgagctt ggcgttgata tcgtgaacct 1110781 cggcttggta tatgacgttg atatggatga agatggcttg acgcacatca ccatgacgct 1110841 aacatcaatg ggatgccctt tagcgccgat tatcgtggat gaggtgaaaa aagcattagc 1110901 ggaccttcct gaagtgaaag acacagaggt tcacattgta tggaatccgc cttggactag 1110961 ggataaaatg tccagatacg caaaaattgc gcttggcatt caataaaaca aaaaaggaca 1111021 gcctgacatg tgaggctgtc cttttttaca gctgaaagga gtgaaaggaa atgatgtacc 1111081 tgctggcagt tttatgcccg ccgcttgctg ttttgttttc gggaaaaccg tttcaggcct 1111141 tgctgaatct catattgacc tgtatctttt ggctgccggg cgcgattcac gcctgcttta 1111201 tcgtcgccga ccgccgtgcc gaaaaacggg caagaagata atttggaaaa atgaggacgc 1111261 agtcatggta taatggtcat aaaaacagca gggagagcac tatgaaaaag aaattgcttg 1111321 cattcgcgct ttgtactggc gcgtatgcgg ccctgtttgc gtactctgtg aactcagagc 1111381 aaaaaacagc cacaagcgag atgacggatg tcagccgcct gatgcctgta aaaataaagc 1111441 agacagtgaa agggcaggaa gaggaaatgc tcattgacac agtcaaagag gcaaatcgaa 1111501 aaaacataaa aatttcaatc gccggggccc agcactccat gggcggccat acatattatg 1111561 aggacggcat cgttctcgac atgacgggct acaacaaaat cctgtcactc gatcaagaga 1111621 agaaaaccat cagggtgcaa agcggtgcaa cgtggaatga tatccagaaa tacgtgaatc 1111681 catacggact cgcggtaaaa gtcatgcagt cacaaaacat ttttacaatc ggcggatctc 1111741 tcagcgcaaa tgcacacgga cgtgatattc gctacggctc gctaattgat acagtcaaat 1111801 cattccggct tttaaaagct gacgggatga ttatcactgt cactccaaaa gatgatttgt 1111861 ttacggcggt catcggaggg tacggccttt ttggcgtgat tcttgatgta acgcttgagc 1111921 tgacagatga tgagctgtat gtcatgaaga cagaaaaaat gaattacagc acatactcag 1111981 actatttttc aaagcatgta aaaggaaatc cagatgtccg aatgcatctg gcgcgaattt 1112041 caacagcgaa aaaaggattt ctgaaagaca tgtatgtcac gaattacgta ttggctaatc 1112101 atcaggatca gctgtcctca tacagcgaac ttaaagaaga cgagtatacg ggagccacaa 1112161 agtttgcact cggcttgtca agacggtatg aatgggggag gaattggctg tgggacacac 1112221 agcaatccta tttcctgagc cagaacggca cagagatttc acgcaataac gtcatgcggt 1112281 ccgaatcaaa gtttcttgag tatgaaaaca atgacaacac agatgttttg caagaatact 1112341 ttgtgcccgt gaaggagtat gggtcctata ttgatgacct gagacaaacg ctgtcggacg 1112401 aagatctgaa cctgctgaac attacgatcc gctacgtgca gaaaaatgaa aaggccgacc 1112461 tttcctatgc gaaggacgat atgttttcgc tcgtactatt aataaacgag ggcttttcaa 1112521 aagaagacca ggcagatacc gcccgaatca tcaggcgcat gacagacgtt gccatcaagc 1112581 acggcggcag ctattatctg ccttatatga cctaccagac aaaagcgcaa atgagacagg 1112641 catatccgaa aagtgaagcg ttttttcaga aaaaacgaac ctatgacccg gatgagcgct 1112701 ttatgaatta cttttatcag aggtataaat aatggggaaa aacaaattaa aatggctgac 1112761 attatcacaa agcagcgtgt ttttcgcaag cagcttaatc tttccgtttt atattctgtt 1112821 tgtgaaaaat atcggctcaa gctacacaca gttcggtttt tcctacggat tgttcgggtt 1112881 gagcggagcg cttatttacc cgctcctcgg acggctgtct gaaaggtttg acagccgtta 1112941 ttttctgctt ctgaactcgt gggggatggc tgttctgctt ttatatgtcc cgcatatcgg 1113001 aagcgtcgtt caagtgtata tcgtccaagt gctgttaggg ctctttggag cgatgcaaaa 1113061 gcatggagaa aaagtgctga tcgctaattt tacagacagt ggagagcgtg gaaagaagat 1113121 cgggaattac catttttgga cagctgtctt ttcagcagca gccattatgc tcgggggctt 1113181 tctcgctgac tttttcacag tgcaaatgat tttttatgca agctctattc tatatttttt 1113241 gagtggattg atgatgatga aaacaggctg acgcggtcag cctgtttttt tatgcggctg 1113301 aaatgcggca ccgcatcaac gtttttgtgc tggagtcgtg ctgatttttt ttgagcggaa 1113361 ttcccattga acagaaaatt tataaatgaa taaaaatatt aaatatacga ttgaattaat 1113421 ttttattcat gttataatgt taaataattt cacaaagacc aagagggtga acttgttttg 1113481 aaaataggaa ttgtaggtgc tacaggatat ggaggcaccg aacttgtcag gattctttcg 1113541 catcatcctc atgcagagga atgcatactt tattcatcca gcggagaagg gaatgtctat 1113601 agcgagggtt atcctcatct taccggctta gcggatcagc agctgaagcc gattgatatg 1113661 aatacgatca aacacgaaat agatatcatg tttctcgctg cgccgcccgg agtatcaagt 1113721 gaattgactc caaagctggc agacgcggga attacggtta ttgatctgtc aggtgatctg 1113781 aggataaaag aaccggctga atatgaaaaa tggtataaac ggacagcggc accgaaggcg 1113841 gtgattcaag aggcggtata cggtctggca gaactgaatc aactgcaaat tcaacaggcg 1113901 aaactcattg ccaatccagg ctgttttcca acagctgttt tgcttggcct cgcgccattg 1113961 gctcaaaaga aactgctcga tgaatctttc gttatcgttg acgcgaagac cggtgtttcc 1114021 ggagcgggaa gaaaagcatc catgggaact catttttctg agctgaacga caattttaaa 1114081 atttataaag tcaatgaaca tcagcacacg ccggaaattg agcaggcgct gaatgaatgg 1114141 cagccaggtc tcgggcccat tacattttcg gctcacttgg ttccgatgac aaggggcatc 1114201 atggcgacga tgtataccag attaacctgt gacctaaccg cagatgacct gcatgattta 1114261 tattcggaat tttaccaaga ttcatatttt gtgagagtga ggccaaaagg tcagtacccg 1114321 caaacgaaag aagtgtacgg cagcaatttc tgtgatatcg ccgtgaccct cgatgagaga 1114381 acgaacagag tcacgatcgt ctcggtaatc gataatttaa tgaagggtgc cgccggtcag 1114441 gcagtgcaaa actttaattt gatgaatggc tggaatgaag aaactggact caccatcacg 1114501 ccaatttatc catagaacgg gagagaatcg aaccatgatt cagttaagtg aagatcaaat 1114561 tgtaaaagta acaggtgatg tatcctcgcc aaaagggttt caggcaaagg gtgtgcattg 1114621 cggactgcgc tactcgaaaa aagacctcgg cgtcattatc agcgagacac cggccgtgag 1114681 tgcagcagtt tatacccaaa gccactttca ggctgctccg atcaaagtga cacaagacag 1114741 cttaaagcac ggaccgacac tgaaagccgt catcgtcaac agcgccattg ccaacgcctg 1114801 cacgggagaa cagggcttaa aggacgcata cacaatgcgg gagagctttg cttcacagct 1114861 tggcattgag ccggagcttg tcgctgtttc atcaacgggt gtcatcggcg agcatttaga 1114921 catggaaaaa atccacgcgg ggatcgaact gctgaaagaa acacctgcgg gatcaggcga 1114981 ttttgaggaa gcgattttaa caactgatac ggtgatcaag cagacgtgct atgaactggc 1115041 aatcggcggc aaaacagtca cgatcggcgg agcggccaaa ggctctggga tgatacaccc 1115101 gaacatggcc acgatgctgg gatttgtgac aactgacgcg gcaatcgaag aaaaagcgct 1115161 gcaaaaggcg cttcgggaaa tcactgacgt ttcatttaac caaatcacag ttgacggaga 1115221 aacatccacg aacgacatgg tattagttat ggcgaatggc tgcgccgaaa acgagtgcct 1115281 gacagaagac catccagact ggccggtctt taaaaaagcg ctcttgctca cttgtgagga 1115341 tctagctaaa gagattgcca gagacggaga aggcgcgaca aaactaattg aagcccaagt 1115401 acagggagcg aaaaacaatc ttgatgcaaa cgtcattgcc aaaaagattg tcggctcaaa 1115461 tcttgtaaaa acggcagtat acggaacaga tgccaactgg gggcggatca tcggagccat 1115521 cggacactcc gcagcacagg tgacggcaga agaagtagag gtttatcttg gcggccaatg 1115581 cctgtttaag aataacgaac ctcagccatt ctctgaatct atcgccaagg aataccttga 1115641 aggagatgaa atcaccattg tcatcaagat ggctgaaggg gacggaaacg ggagagcgtg 1115701 gggctgtgac ctgacctatg actatatcaa aattaacgcg agctatcgca cgtaataaag 1115761 gggagcgaaa tgaagaaaac aatcgttttt aaatgcgggg gaagcgtcat ccgtgagctg 1115821 tcggaggaat tttatcaaaa tctgaaagag ctgagggcgt caggctggaa gctggcaatc 1115881 gtacatggcg ggggaccgga aatcacaaat atgctgaaac ggttaaatat caagacagag 1115941 ttttcgggcg gacagaggaa aacaacgaag ccggtgctgg aagtggcgga aatggtttta 1116001 tccggttctg tcaataaatt tttcgttgct gagcttgcca aacacggact gcgagccgcg 1116061 ggcatttctg gtaaggatgg cggtcttttg gaggctgatt atctagatcc ggaaacatac 1116121 ggagaagtgg gagaaatcaa aaaagtcgat gcgtccatgg tgaacgcgct gatggaaaat 1116181 ggcatcatcc ccgttattgc gccgctgtct atgacaagcg actgcaaaac gctgaatgta 1116241 aatgctgatc tggctgcttc agcagtcgcc ggagcgcttg aagccgataa gctgatgttc 1116301 gtcacggatg tcgatggaat catgaaggaa aagcagcgtc tggacgtcct gacccctaag 1116361 gagattcaga tgctgatcaa gcaggaagtg atcacaggag ggatgatccc gaaggtcaat 1116421 tcagccttgt cagctttatc agatcaggtg tctgaagtca tgatcgtaaa cggtaaagga 1116481 tcattcttcg cagaacaaac ctttcaaggg acaaaaattg tcaaagcaaa ggaggctgtt 1116541 tcatgagcag cttgtttcaa acctacggcc gttgggatat tgacatcaaa aaagcaaagg 1116601 gaacgtacgt tgaggatcaa aacggcaaaa cgtaccttga tttcattcag gggattgcgg 1116661 tatcaaatct aggacactgc catgaagcgg tgacagaggc agtcaaaaaa cagcttgaca 1116721 gcgtatggca cgtatccaac ctgtttcaaa acagtctcca agagcaagcg gcgcagaagc 1116781 tggcagcgca tagtgcggga gatcttgtct ttttctgcaa cagcggcgcg gaggcgaatg 1116841 aaggtgcgat aaagcttgcc agaaaagcaa ctggaaaaac aaaaatcatc acttttcttc 1116901 agtcgttcca tggccgcacg tatgcaggga tggctgcgac cggacaggat aaaatcaaaa 1116961 caggcttcgg cccgatgctt ggaggctttc actacctgcc atacaatgat ccttctgctt 1117021 ttaaagctct tggggaggaa ggcgatattg ccgcggtgat gcttgaaaca gtgcagggag 1117081 aaggaggagt caatccggcg agtgctgaat ttttatcagc cgtacagtcg ttttgcaagg 1117141 aaaagcaagc ccttctcatt attgatgaaa tccagaccgg catcggacgg acgggaaaag 1117201 gcttcgcata tgagcacttc ggactctcac cggatatcat cacagtcgcc aaaggattgg 1117261 gaaacggctt tccggtcggc gctgtcatcg gaaagaaaca gcttggagaa gcgtttaccc 1117321 ctggttctca cggaacgact ttcggaggaa acatgctggc gatggctgct gtgaatgcca 1117381 cattgcaaat tgtattccag cctgactttt tgcaagaggc tgctgacaaa ggggcgtttt 1117441 taaaagaaca gcttgaggca gagctaaaga gcccttttgt taaacaaatc cgaggtaaag 1117501 gattaatgct tggaattgag tgtgatggcc cggttgctga cattattgct gaattgcaga 1117561 cattaggctt gcttgtattg ccggccggcc cgaacgtgat tcggctgctg ccgccgctca 1117621 ccgtgactaa ggatgaaata gcagaagccg tcagcaagct gaaacaggca atcgctcatc 1117681 attccgctgt aaaccagtga ttttttttcg atataaaggc ataaaaattc atttttataa 1117741 ttaattattc atcaagaggt gggctgttag atggaaggtt atttagtgtt agaagatggg 1117801 acatcgttca gcggcgagct ggacggtcat gaaaactgca cgggagaagc tgtttttttc 1117861 acaggaatga caggctacca ggaagtgctg acagatccat catataaggg acagattatt 1117921 gtatttacct acccgctgat tggcaactac ggcataaatg aaaaggattt tgaaagcaag 1117981 aaaccgcaag taaaagccgc ggttgtctat gaggcgtgtg atcacttttc tcattatgaa 1118041 gcggtataca gcctcaagga gtatctacag aaatggaata ttccgctgtt aacccatgtt 1118101 gatacgaggg ctgtcgtgaa gaaaatccgg gcaaacggga cgatgggtgc gacagtcaca 1118161 gcctctaaag aaggagctga gattgccctt caaccagaga atgtggcaga gcaggcttcc 1118221 gcccaggaaa tcagcacatt cggcgacggg aataaacata tcgctctcat tgattttggc 1118281 tataaaaagt caatcgcatc atcacttgtc aaacgaggct gcaaggttac cgtggtgcca 1118341 taccagcaaa tggaggccgt atacaacatc aaacccgatg ggctatcgaa cggacctgga 1118401 gatccgaaag ccattcagcc atatttagga aagatcaaaa gcatcatcag ccgctttccg 1118461 actctaggca tttgtctcgg acatcagctg atcgcgctcg cgtttggagg gaatactttt 1118521 aagctgccat tcgggcacag gggagctaat catccggtca tcgaccgtaa gacgaaacgg 1118581 gtctttatga caagccaaaa ccacagctat gtggttgatg aacagtcgat taatgaagaa 1118641 gagctcacca tcaggtttca tcatgtcaat gatacgtcag ttgaagggct tgcccataaa 1118701 aaactgcctg tcatgagtgt tcaattccac ccggaagccc atcccggacc tgcggaaagc 1118761 gaatggattt ttgatgatta tctaaagaat gtgataccag caaggagaga aatcgcgcat 1118821 gcctaaagac accagtattt caagcatatt agtaattggc tcaggcccga tcatcatcgg 1118881 gcaggcggca gaatttgatt attcaggcac tcaagggtgc atcgcgctga aggaggaggg 1118941 ctaccgggta attctcgtca acagcaatcc ggcgacaatt atgactgatg aagccttcgc 1119001 tgatgaaatt tattttgagc ctctgacagc agaaagcctg acagccatca ttaagaaaga 1119061 acggcctgat gggcttcttg ccaatttagg cggtcagacc gcgttgaatt tagcggtgga 1119121 gcttgaagaa acgggtgttt taaaagagca cggcgtcaaa ctcctcggca catccgttga 1119181 aacgatacaa aaaggagagg accgggaaaa attccgttcg ttaatgaatg aattaaaaca 1119241 gcctgtgccg gagagtgaaa ttgttgataa cgaggccgat gccctccatt ttgcggaatc 1119301 catcggtttt cctgttatta tcagaccagc ttacacatta ggcggaaagg gcggaggaat 1119361 cgcccctgat aaagaagcct ttacagctat gattaagcag gcgctattag caagcccgat 1119421 caatcaatgc cttgtcgaaa aaagcattgc cggctttaaa gaaattgaat atgaagtcat 1119481 gcgtgacagc aataacacat gcattaccgt ctgcaatatg gaaaatatcg atccggtcgg 1119541 cgtgcataca ggtgactcta tcgttgtggc gccgtcacaa acattgacag acgaagacta 1119601 tcaaatgctg cggacagcaa gtctgacgat catctcagca cttgatgttg taggcggctg 1119661 caacattcaa ttcgcgcttg atccattcag caagcaatat tacgtcattg aagtgaatcc 1119721 gcgtgtaagc cggtcatcgg ctctcgcatc taaagcgacc ggttatccga ttgcgaagat 1119781 ggccgcgaaa ctggcagtcg gatacactct tgacgagctg aaaaatccgc tcacaggctc 1119841 gacttacgca agctttgaac cggcactgga ttatgtgatc gtcaaatttc cgcgctggcc 1119901 gtttgataaa ttcaaaaacg cagaccgcaa gcttggcaca aaaatgaaag ccaccggtga 1119961 agtgatggcg attgaacgga atttagaagc ggcgatacaa aaggcagccg cgtcgcttga 1120021 attaaaaaat atcgggacac accttccaga gctcagcggg ttgtcaattg atacgctatg 1120081 ggatttggca atcactccgg atgaccgcag atttttcgtt gtcatggagc tgttgagccg 1120141 cagcgtctcg attgatgaca tccatgaaaa aacaaaaatt gatccgtttt tccttcatac 1120201 ctttgacaac atcatcaaat tggaaaaccg cctgatggaa gcagggagcg atctctcttt 1120261 tgaattattg aagaaagcaa aggaaaaggg attctcagac gcaacgattg cctcgctgat 1120321 cagcaaaaca gaagaagagg tgcgcgcgct tcgcaaggag atgggcatta cgccttcctt 1120381 taaaatcgta gatacatgcg cggcagagtt tgatgcgaaa acaaactatt tttactccac 1120441 atatttcgga gagaccgatg gagacatcag ccgcaaagag aaaaaacgcg cgctcattat 1120501 cggatcaggc ccgattcgga tcggccaagg cgttgaattt gattacagtg ctgttcacgg 1120561 tgtgctgaca ctgcaagagc ttgggttcga aaccatcatg attaacaata acccggaaac 1120621 tgtcagcacc gattatgaaa ttgcggaccg cctgtatttt gaaccgatga caacggagca 1120681 tattgtaaac gtggcggagc aggaaaatat tgattttgca attgtgcaat ttggcggtca 1120741 aactgcaatc aatgctgctg aagcgctcga aaaagccggc attactcttc ttggcacatc 1120801 atttcaaacg ctcgacgtgt tagaggatcg ggatcaattt tatcagcttc ttgacgagct 1120861 gggattgaag cacgcaaaag gagaaattgc ttatacaaaa gaagaagccg cttcaaaagc 1120921 gagtgagatc ggctatccgg tgttaatccg cccatcttac gttatcggcg gaatgggcat 1120981 gatcattgtt gactcgcaag cccagctttc tcagctgctg aatgatgagg acagcatgcc 1121041 atacccgatt ttaattgatc agtatgtgtc tggaaaggaa gtcgaaattg atttgatttc 1121101 cgacggcgag gaagtcttta tcccgacata taccgagcat attgaacggg caggtgtcca 1121161 ttcaggggac agttttgcca ttcttcccgg accgtccatc acgagcgggc tgcagcaggg 1121221 catgaaagat gcggcacaaa aaattgcccg aaaactttca tttaaaggca tcatgaacat 1121281 tcaatttgtg atcgacaatg gaaacatact cgttcttgaa gtgaatccga gagcgagccg 1121341 cacggttcct gtcgtcagca aagtaatggg cgttccgatg attccgctcg ccacacgtct 1121401 gctggcggga gcgtccttaa aagatctaaa tccggcagtt caaaatcatc atggagttgc 1121461 cgtgaagttc cctgtttttt cttctcatgc gatccaggat gtggatgtca agcttggacc 1121521 ggaaatgaaa tcaacgggag aaggcatgtg tgtcgcatat gattctaaca gcgccttgaa 1121581 aaaaatctat acaagagtct ggagtcaaaa aggaagcatt tatttgcaaa acgttccgga 1121641 agatgtgaag gagttagcag aaaacgcagg ttttacaata catgaaggaa catttgcctc 1121701 atggatggaa caggaaggaa actcgctcca cattaatctg agcggttctg aagaagcacg 1121761 caaagaacgt ttggaagcca tgacgcacgg catccccgtc tttacagaag aagaaactgt 1121821 gcgggcgttt ttacaaagcg gttcaggcca tccgcagcct gtatctctca aagacctcta 1121881 taaaaaggaa gtggcatcat gcacacagtg acgcaaacca gtttatacgg aaaagattta 1121941 ttaacgttaa aggaccttag tgaagaagat ataaacgcct tgctcgcaga agccggtgag 1122001 ctgaaacaaa acaaaattca gcctatattc catggcaaaa ccttggcgat gatttttgaa 1122061 aaatcatcaa cgcggacccg tgtttcattt gaagcgggca tggcgcagct gggcgggagc 1122121 gccctctttc taagccagaa agatctgcag ctggggcgcg gtgagactgt cgctgatacg 1122181 gcaaaagtgc tgtcaggcta tgtggatgcc atcatgatcc ggacctttga acatgaaaag 1122241 gtggaggaac ttgccaaaga agctgacatt ccggtgatca atggacttac cgataaatac 1122301 cacccatgcc aggcgctggc ggatctcttg acgattaagg agataaaagg gaagcttaaa 1122361 ggcgtaaaag tcgcgtacat cggtgacgga aataacgtgg cgcactcctt gatgatcggc 1122421 tgcgcgaaaa tgggctgtga tatctcgatc gcttcaccaa agggatatga agtgttagat 1122481 gaagcagctg aagcggcaaa gacatatgca cttcaatccg gctcttctgt cacgctgaca 1122541 gatgatccga ttgaagctgt aaaagacgcg gacgtgattt attctgatgt gtttacaagc 1122601 atggggcagg aagcggaaga gcaagaacgt cttgctgtct ttgcgcctta tcaggtgaat 1122661 gcggcgctgg tcagccatgc caagcctgac tatacatttt tacattgtct ccctgcgcat 1122721 cgcgaggaag aagtgactgc ggagattatt gacgggccga actctgcagt gttccagcag 1122781 gcggaaaacc gtcttcatgt gcaaaaagca ctgctgaagg ccattttata taaaggggaa 1122841 tcatcaaaaa actgctgagc caaactcagc agtttttttg atggcaacat attcacagcc 1122901 gcttaggcgc atactacagc aaaaaggaaa aggaggaaaa acagtgggac agcagcacca 1122961 attccggccc ggacagaaag cgcctaataa cggtgtctac gtagaaatcg gcgagacagg 1123021 gagcatggtt aaaaaccctc aaaaggtcca tctgtcagca ggggaaatgt tccccgaaac 1123081 atcaaaccac aaccggctgt ggacctacaa aagaaagccg tgaccactaa aaaacccaaa 1123141 acaataaatg ttttgggttt ttggcttttt aatgctggct tgcatttttg ttcataggca 1123201 tgatttctgc taaaaccatg attaagacat acagtacaac agcaatgaca gatgatgttt 1123261 tgaaattata cgtaacgctg ttcatgcttg caaccaagta gcatgccata tgtgataaaa 1123321 ggaacgtcca aataaaggca ataatatatc gcacgtttcc acctcgtcct tctcattcta 1123381 ttctaaaagt tatcatacca tacaaaaagc gaagggggaa tccaatttta gcagaaagtg 1123441 aggtgacaaa agagtctgat tcgtcacact ttaatggtaa aatataaaac gtcaatcagt 1123501 ataatagcca aaaatgtaaa aggctaggac tttaccttat tcgtttcttt tctatttaca 1123561 taagatagcg tgagatgaag tgtgaaagga ggcgggcaag cgatgggaat aacggaaaga 1123621 tactttcaac tgggaacgga gcataatgtc attcatctgc cctatcgccc gaacggcttc 1123681 ggcatcttta tcttggggga cagaacccac tttgtcggac atgattcaag cttttggcag 1123741 cagcattatg gcagaaatca gcttctgagc atgttgatga atgaaggata cactcttttt 1123801 aacagcaatc tgttcggaag gcattggggg gcggaaaaag cagtcaccta tgccaaacag 1123861 ctgatacatt ctgtgctgaa gcaggaaatc ctcaatccga agattcatat tttagcagaa 1123921 ggcatgggtg ctctcgtggc cgatgaactg cttcgttttt ccccggatca tatccgctca 1123981 gccgcaatgt tgaatccttg tctcgatctt caggcacatt atgaatcgga aaaagaaaat 1124041 aaatttttct ataagcaatt tttgaaagaa gtatcgaaaa gctacggaat ttctgaaaaa 1124101 gaagcggaag cgattcgtta taaaacaatt caaagctacc cgagcggcgt accggttcat 1124161 atatggcagc gtatgaccgg agctccatat ccctacagcg tacatgcgga agttttcaag 1124221 gaaaaacagc aaaagcaagg ctcaccggtc gacatgacat ttcatttatt tgagcatcca 1124281 agcagaattt atgcatcaat ttgcaaattc tttcatagtc atgaaaaaga attatagaga 1124341 atataatgac aacagccttc tcttttgcgg aggctgtttt gttttgggaa atgaaaaacc 1124401 ggaagggcgg cagatgcaat ggaatcaacg ctgattgtag gtgcggacga atttttcggc 1124461 ctttcattat gtgagcgaat gatggatgaa ggcatacatg ttgacgttgt tctggcggaa 1124521 acagaagata aaatgagaca aatgtactta gaagaaagac tcatgtggct tgggagaaat 1124581 gaactctttc gccagcttga acacattgga gaccaaaatt atgatacaat ttgtatccag 1124641 ttcggaagtt ttttgccttt agaccaatat gattctcctt atattttagt atatgaagaa 1124701 gaccgaaaag aatgggataa acgtgaaaaa acaggctcgg aaaaaaccgt gatcctgccg 1124761 aaaatgtacg ggccatggaa agaagaaaca gaggaagacg gctattacac aaacgacgtg 1124821 gctgacgagt tgctgagatt cctgttagaa ccaagccgtc atagcaaaga tcagcttttt 1124881 gaattgcaag tcacagagaa aacctcaaaa gaagaagcaa aaacaaaaat tatcgagtgg 1124941 aaaagacaat tttcatcaat tttcgacaaa tattaagaaa aaccttccat gtttcgagtt 1125001 ttctagatac aataaacgta taaaaataat acatgttata gcttgtcaaa aggagttgaa 1125061 catgacttga tcacaaggct tgtcatgatc ttttctgtcc tccttttatt gagtggatgt 1125121 ggacaaactc cgttcaaagg aaaaattgag aaggtcggca tgctctttcc tgatacgatt 1125181 aatgacctcg tatggggcac aaaagggtat aaaggattac tgaatataca atccaaatac 1125241 aatgtggacg tctattataa agaaggcgtt aaaacagaag aagatatcat aaatgcgatt 1125301 gaggattttc ataagagggg cgtcaatctg ctctacggcc atgggagtga atatgctgag 1125361 gtgtttaact tggtcggcga agattatcca gatatggaat tcgtcatttc caatgcgaaa 1125421 gcgaaagctg ataatgtaac aagtgtccat tttagcgggg aagcaatggg cttttttgga 1125481 ggaatgactg ctgcccatat gtcgaaaacg aatcaggtcg gtgtaattgc ttcctttacg 1125541 tggcagcctg aggttgacgg ttttatcaaa ggggccaagt atgaaaatcc ggatatagag 1125601 gtaaatacga aatatacgga tcattgggat gatgatacaa cagcagtaaa gctttatcag 1125661 aaaatgaaga acgaaggcgc ggatgttgtg tatcccgccg gagacgggta taatgttcct 1125721 gttattcagc aaatcaaaaa agacggtctt tatgccatag gctacgtcac agatcaatcg 1125781 gatctgggcg agaataccgt attaaccagc acggtgcaaa atgtggacaa ggcctatgaa 1125841 atcattgctg aacaatttaa taaaggcacc cttgagggcg gcgatcatta ctacgacctg 1125901 aacacgggag tcgttgagat gggaacattc agcccgctcg tcgatcaaga ctttcagcaa 1125961 agaatcgcca agctgatcaa aacatacaac aaaacaggcg agctgccaaa aaacgagtaa 1126021 tggagtgacg tcacatgcag cacgaaaaat cacttgaatt cttgcaaatt gccatgaaat 1126081 atctccctga agcgaaagaa cagcttgaga aatcaggcat tgagctctca atggaggcca 1126141 tccagccgtt tatgaatcta tttacaacgg taatggcgga agcttatgag cttggcaagt 1126201 ctgacgctaa atctgaaaca gaataagaag aagccacttt tttgaaagtg gcttttcaca 1126261 tgattttctt tttaatagcg gagagcatgg gcgcaagctc ctttaaagcg ggcttgattt 1126321 gatcaagaga gttcataatt gaaccgattt ggtccataat atgcatgtaa ttaatcgtct 1126381 cttcgtcgtt tgtctgagaa acctgagaaa cttcctcttg ctgttcctcc tccttctctt 1126441 ctgttggttt tgctgcatcg ccgaacatca ttcttgaaaa cacatccaac tgcatacgcc 1126501 tcctttccat ataccatact ctatgagtaa gatgaactga tagtttagac gaatatattg 1126561 ccatgtgaaa aaaaatagga tagaattagt acctgatact aataattgat cacaacctga 1126621 ttgatcttct aaatttaaga tataaaggag tcttccctaa tgaaagctgg aatacttggt 1126681 gttggacgtt acattcctga gaaggtttta acaaatcatg atcttgaaaa aatggttgaa 1126741 acttctgacg agtggattcg tacaagaaca ggaatagaag aaagaagaat cgcagcagat 1126801 gatgtgtttt catcacatat ggctgttgca gcagcgaaaa atgcgctgga acaagctgaa 1126861 gtggctgctg aggatctgga tatgatcttg gttgcaactg ttacacctga tcagtcattc 1126921 cctacggtct cttgtatgat tcaagaacaa ctcggcgcga agaaagcgtg tgctatggat 1126981 atcagcgcgg cttgtgcggg cttcatgtac ggggttgtaa ccggtaaaca atttattgaa 1127041 tccggaacct acaagcatgt tctagttgtt ggtgtagaga agctctcaag cattaccgac 1127101 tgggaagacc gcaatacagc cgttctgttt ggagacggag caggcgctgc ggtagtcggg 1127161 ccagtcagtg atgacagagg aatcctttca tttgaactag gagccgacgg cacaggcggt 1127221 cagcacttgt atctgaatga aaaacgacat acaatcatga atggacgaga agttttcaaa 1127281 tttgcagtcc gccaaatggg agaatcatgc gtaaatgtca ttgaaaaagc cggactttca 1127341 aaagaggatg tcgacttttt gattccgcat caggcgaaca tccgtatcat ggaagctgct 1127401 cgcgagcgtt tagagcttcc tgtcgaaaag atgtctaaaa ctgttcataa atatggaaat 1127461 acttctgccg catccattcc gatctctctt gtagaagaat tggaagccgg taaaatcaaa 1127521 gacggcgatg tggtcgttat ggtagggttc ggcggaggac taacatgggg cgccattgca 1127581 atccgctggg gccgataaaa aaaggtgagg tgcacacaag atgactaaaa aaagagtagt 1127641 tgttacagga cttggagcat tatctccact tggcaacgac gtcgatacaa gttggaataa 1127701 cgcaatcaac ggtgtgtccg gaatcggtcc gatcactcgt gttgacgctg aagaatatcc 1127761 ggcaaaagtt gccgctgaat taaaagattt taatgttgaa gattatatgg ataaaaaaga 1127821 agccagaaaa atggaccgct ttacacaata tgcggttgtg gctgcgaaaa tggcggttga 1127881 agatgcagat cttaacatta ccgatgagat cgcgccgaga gtcggtgttt gggtaggctc 1127941 cggtatcgga ggacttgaaa cactagagtc tcaatttgaa atcttcttaa caaaaggccc 1128001 aagacgggta agcccgtttt tcgtgccaat gatgattcct gacatggcga caggccagat 1128061 ttctattgca ttaggagcaa aaggggtgaa ctcttgtacg gttacagcat gtgctacagg 1128121 aacgaactcc atcggtgacg cgtttaaggt tattcagcgc ggtgatgcag acgtgatggt 1128181 cacaggcgga acagaagcgc cgctgacaag aatgtcattc gccggcttta gtgccaacaa 1128241 agcgctgtct actaatccag atccgaaaac agcgagccgc ccgtttgata aaaaccgtga 1128301 tggctttgtc atgggggaag gtgcagggat tatcgttctt gaagaacttg agcatgccct 1128361 ggcccgcggc gctaaaattt acggagaaat tgtcggctac ggctcaaccg gagacgctta 1128421 tcatatcaca gcgccggccc aagacggtga aggcggagcg agagcgatgc aagaagccat 1128481 taaagatgca ggcattgcac ctgaagaaat tgattacatc aatgctcacg ggacaagcac 1128541 gtattacaac gacaaatacg aaacaatggc gattaagacc gtttttggcg agcatgcgca 1128601 taaacttgcg gtaagctcta caaaatcgat gacaggccac ctcttaggag cagccggcgg 1128661 tattgaagcc attttctcta tcctggccat taaagaaggc gtgattccgc cgacaatcaa 1128721 tattcaaaca cctgacgaag aatgtgattt ggattatgtg cctgatgaag cccgcagaca 1128781 ggaacttaat tatgttctca gcaactcatt aggattcggc ggacacaacg caacattaat 1128841 ctttaaaaaa tatcaatcat aatcaagcca aaccggctgc ccttaaaggg tagccggttt 1128901 tttttgtgtg cataggatta aaagaggagg cgatcacatg agtgtagaac aaacatatag 1128961 ctggctcagg aaggccggtt caatagatga tttggcgcat tacattatcc cgcttttttc 1129021 aggtgcggag aaaaagaact ggaagggcat tctggggcat cttcagcatc atgggatgtt 1129081 taaaaacata aaagagggta ttcagacggt ttccaagctg aaggaaaaag gtttttacgg 1129141 acatatccaa aaggaagaac agtacctcaa aaacaaatgg caaggtcctg atgtaccaat 1129201 tgttacgctg ccggttgatg aacgaaacag gagaatccgt ttagaattcg gatcaaaatc 1129261 aggactcgcc tttcaagaca aaatgttcct ttttctttcg tcagatttag attttgggtc 1129321 ggtatctgcc cttatgacgc atgagtatca tcacgtttgc cggttaggtc atctgacaaa 1129381 agaggaaaag gatgtcacat tacttgatac aatcatcatg gaagggctgg cggaatatgc 1129441 tgtttatgag aggttcggcc gaagtcaaac ggctgaatgg acgacttggt atacaccgga 1129501 acagcttcag gctttatatg aaaaaaagat tgcgccccat cgggatatca aacgggataa 1129561 tcgattattt ccccagctgt tattcggcaa aggatatcag ccaaaaatgc ttggatacgc 1129621 agttggattc aatattgtaa aaaaatattt aaccgccagc aaggcaagca ccgcagacgg 1129681 gctgtccatt cctgctgaga cctttttgga tgcaatgctt taaaaggata aaataatgga 1129741 atttcattaa taatattaca tttatcctaa aaaattcttg attttgcaaa atgattgtaa 1129801 taatatacaa ctataaaatt tttcgataat tcaatattat ttattatttc tgaataaagg 1129861 gattgctttc tcttgaaaac gtttgacaac aagagggggg aaaggggagc tagcatgagc 1129921 acacttttag aagtgaataa tttaaagact tattttttca ggaaaaagga gccgatccct 1129981 gcggttgacg gagtcgattt tcacatcagc aaaggcgaaa ccgtcgcgct tgtaggtgaa 1130041 tcgggctccg gaaaaagcat tacttcttta tcaattatgg gcctcgtcca aagctcaggc 1130101 ggaaaaatca tggacggctc tattaaactc gaagacaaag acctcacctc attcactgaa 1130161 aacgattatt gcaaaatccg cggtaacgaa gtatccatga tctttcagga accaatgacc 1130221 tcccttaatc cggtgttaac aatcggagaa caaattaccg aagtgctgat ttaccataaa 1130281 aacatgaaga aaaaagaagc ccgtcaacga gctgttgaac tcttgcagat ggtcggtttc 1130341 tcccgggcgg agcaaattat gaaggagtac ccgcatcggc tgtccggcgg tatgagacag 1130401 agggtgatga ttgccatcgc actgagctgt aatcctaaac tgctcattgc tgatgaacca 1130461 acgacagcgc tggacgtgac aatacaagcc caggtgctgg agctcatgaa agatctctgt 1130521 cagaagttca atacatcgat tcttctcatc acacacgact taggtgtcgt gtctgaagct 1130581 gccgatagag tgattgtcat gtactgcgga caagtcgtag aaaacgccac tgttgatgac 1130641 ttatttttag aaccgcttca tccgtataca gaaggcctgc ttacgtcaat tcctgttata 1130701 gatggagaga ttgataaatt aaatgcgatt aaaggcagtg tgcctacacc ggataatctg 1130761 ccgccggggt gccgttttgc cccaaggtgc ccgaaagcta tggataagtg ctggacaaat 1130821 cagccttcgc ttttgacaca caaaagcgga agaacggtga gatgcttttt atatgaggaa 1130881 gagggtgccg aacaatcatg acagcagcta atcaagaaac aatcttagag cttcgtgacg 1130941 taaaaaaata ctttccgatc cggtcaggcc tttttcaaag aaaagtcggt gatgtaaaag 1131001 cggtggatgg tgtttcattt tcgttaaaaa aaggagaaac actcggaatc gttggagagt 1131061 cgggctgcgg aaaatcgact gccggcagaa cgatgatcag actgtacaaa ccgacagagg 1131121 gccaaattct ttttaaaggg caggatattt ccaatctgtc agaggagaag ctgcggaaga 1131181 gtgtccgcaa aaatattcaa atggttttcc aagatccatt tgcttcgtta aacccgagaa 1131241 agaccctgcg ttccatcata aaggagccgt ttaatacgca caacatgtat accatgcgtg 1131301 aacgaaacga aaaagttgaa gagctgcttg caagagtagg gcttcacccg tcgtttgccg 1131361 gccgttatcc ccatgagttt tcaggcggcc agcgtcagcg gatcggcatt gccagagcac 1131421 tcactttgaa tccagagctg atcattgcag atgagccggt ttccgcactt gatgtatcca 1131481 ttcaggccca agtgattaac ttgatggagg aattacagga agaatttaat cttacgtatc 1131541 tatttatctc tcatgatctg agtgtcgtcc gccatatcag cgacagagtc ggagtaatgt 1131601 atcttggcaa aatgatggaa ctgaccggca agcatgagct ttatgacaac ccgcttcacc 1131661 catataccca agcgctttta tcctccgttc cggttacaag aaaaagaggt tctgtcaaac 1131721 gtgaacgcat tgtcctgaag ggagaactgc ctagtccggc caacccgcca aaaggctgcg 1131781 tattccacac aagatgtcct gttgcaaaac cgatatgcaa ggaacaaata ccagaattta 1131841 aagaagctgc tcccagccac tttgtggctt gtcaccttta tagctaatgt tgcccgcaca 1131901 gctttgagag ggggtatgca cactacataa acaacagcct agaagaacga acatttcaag 1131961 agggggaata tctaatgaaa agacggaaaa ccgcactgat gatgctaagt gtattgatgg 1132021 ttctggccat ctttttatca gcctgctcgg gatcaaaatc aagcaacagc agcgcgaaaa 1132081 aatcagcagg caaaccgcag caaggcgggg atttggttgt tggttcaatc ggagaaccca 1132141 cactttttaa ctctctgtat tctaccgatg acgcaagtac ggatattgaa aatatgctgt 1132201 acagcttttt aacgaaaacg gatgaaaaac taaatgtgaa attgtcactc gctgaaagca 1132261 ttaaagaatt agacggcggc cttgcatatg atgtgaaaat taaaaaaggc gttaagtttc 1132321 atgacggaaa agaactgact gcagacgacg tcgtatttac gtacagtgtc cctttaagca 1132381 aagattacaa gggagaacgc ggttcaacat atgaaatgct gaaatccgta gaaaaaaagg 1132441 cgattacgaa gtcttgttta agctgaaata taaagacggt aatttctaca acaatgcgtt 1132501 agacagcaca gctattctgc cgaaacatat tctcggtaat gttccgattg ctgatttaga 1132561 agaaaatgag tttaacagaa agaaaccaat cggttcagga ccatttaagt ttaaggaatg 1132621 gaagcagggc caatatatta agctcgaagc gaatgatgat tactttgaag gaagaccgta 1132681 tttagatact gtgacgtata aagtcattcc tgacgcaaat gctgccgttg ctcagctgca 1132741 ggcaggcgat attaatttct ttaatgtgcc cgccactgac tacaaaacgg ctgaaaaatt 1132801 caacaaccta aaaatcgtta ctgatttggc attaagttat gtgtacatcg ggtggaatga 1132861 aaaaaatgaa ttattcaagg ataaaaaggt tcgtcaagcg ctaacaaccg ctcttgaccg 1132921 cgagtcaatc gtcagccaag tattagatgg agacggcgag gtagcttaca ttccggaaag 1132981 ccctttatct tggaactatc ctaaagatat agatgttccg aaatttgagt acaacgagaa 1133041 aaaagcgaaa cagatgcttg cagaagccgg ctggaaagat acgaacggtg acggcattct 1133101 ggataaagac ggaaagaaat tctcgtttac ccttaaaacg aaccaaggaa acaaagtccg 1133161 tgaagacatc gctgtcgtcg ttcaggaaca gctgaaaaaa atcggcattg aagtgaaaac 1133221 ccagatcgtt gaatggagcg ctctcgttga acaaatgaat cctccgaatt gggattttga 1133281 tgcaatggtc atgggatgga gtttatccac attcccggat caatatgata ttttccattc 1133341 aagccagatt aaaaagggtt tgaactacgt ttggtataaa aatgccgaag cggataaact 1133401 catgaaagat gcaaaatcaa tcagtgacag aaagcagtat tcaaaagaat atgagcaaat 1133461 ctatcaaaaa attgcggaag atcagccgta tacgttcttg tattatccta acaaccatat 1133521 ggcaatgccg gaaaatcttg aaggatacaa atatcatccg aaacgtgatt tgtataatat 1133581 tgaaaaatgg tggcttgcaa aataaatttc ccttaaaggg gagggagagc gttttctccc 1133641 tcttctgttt ttaataagga aagtaaaggg ggacaagtat atggctgcat atattatcag 1133701 aagaacctta atgtctatcc cgattttatt gggaattacg attttatcat ttgttatcat 1133761 gaaagccgcg cccggagatc cgatgacatt aatgatggac ccgaaaatca gccaggctga 1133821 cagagagcag tttattgaaa aatacggtct gaatgatcct cagtacgttc aatatttaaa 1133881 gtggctaggc aacatggtgc agggtgattt cggaacgtct attgtcagaa aaggaacgcc 1133941 tgtttcagaa ttgattatgg caagactacc caatacgctc ctgctgatgc tggtttcaac 1134001 gattttggct cttatgattt ctattccgtt cggtgtcctg tcggcaaagc ggccgtattc 1134061 aaaaatcgac tatggcatta catttacctc gtttataggc ctggctattc caaacttttg 1134121 gtttggatta attttgatta tggtgttatc ggtaaatctc ggctggtttc caactggggg 1134181 tgtcgagaca ctgaataccg aattcaatat atttgaccgg attcatcatt taattctgcc 1134241 tgcattcgtt ctagctacag ctgacatggc cggactgacg agatacacga gatccaatat 1134301 gcttgatgta ttaaatcaag attatattcg cacagcgaga gcaaaaggat ttaaagagaa 1134361 cagagtgcta tttaaacatg gattgaggaa tgcattatta cccgtcatta caattttcgg 1134421 tttgatgatt ccttcattta tcggcggatc tgtcgttgtc gaacaaattt tcacttggcc 1134481 gggattagga aagctgtttg tcgattcagc attccagcgc gattatccgg ttatcatggc 1134541 aatgactgtg atctcggcgg ttcttgtcgt tgtcggaaac ctcattgcag acatccttta 1134601 cgcgattgtt gatccgcgga tcgaatatta aaaggaggga aacagagatg tcagagctgc 1134661 aaacaactcc ctcgccggag atcaggctga aagaaaatat ttcgaaaaag ccagaaacaa 1134721 tgacaaagat tttctgggaa aaattctcga aaaacaaact ggccatttta ggtgccgtta 1134781 ttctttttat cattattatg tctgctgttt tcgccccttt aattgcacct tatccccaag 1134841 agcagcaaag cctgcttgat aaatataagg cgccgggcct tgaacatctg atgggaacgg 1134901 ataaatttgg acgtgatatt ttcagccgga tcctatatgg agcgcgtgtc tctttattgg 1134961 ttggatttgc gtccgtagtc ggttcgattt tgatcggaac ggttttagga gcattagccg 1135021 gatatttcag aggaatagtg gatgctgtca ttatgcgtgt agttgacatt gtgttatcca 1135081 ttcctgatat tttcttgttg atcacgctgg tcaccatctt caagccgggt gtggacaaat 1135141 tgattttaat tttctgtctc acaggatgga ccacaacagc acgattagta aggggagaat 1135201 tcttgtcgct ccgttcaagg gaatatgttc ttgctgctaa aacaattgga acaaaaacgc 1135261 acaaaattat tttttctcat atcctgccca atgcgttagg gccgattatc gtgtcagcta 1135321 cgctgaaagt tgggtctgtt attctagctg aatcggcgct aagctacttg ggctttggaa 1135381 tccagccgcc aatcgctagc tgggggaaca tgcttcaaga cgcacagaat ttcacagtaa 1135441 tgattcaagc atggtggtac ccgttatttc ccgggctatt tattttaatg accgttttat 1135501 gcttcaactt tgtcggtgat ggcctgcggg atgcgcttga cccgaaaaat attaaataaa 1135561 aatgaatatc atatctgtta taaaatatca ccaaatcaga aaaaagcagg tctcctttag 1135621 tcagaaaata tacaaagaga tctgcttttt atgattctta cataaaccca gtgattccag 1135681 atttcctcaa tctctttgga ataatttctc tatcccttgc ctatactgtg gacaacagtt 1135741 tttataaaag tgaggggtta gagatgttat ttcttcatga tgtgtgggtc aattggtttg 1135801 aaggggaaga aaatggctac aatgtatgcc actttcacga atggcgcaag gaagatacgg 1135861 ttgagctttt ggatcaggtg ccgctgttaa gggtgccgtc agtactgttt cattacatag 1135921 aaaacgattt gtcagagctt ccgaaaggtt tgcttgaaga cgtacatcag aaatcgtaca 1135981 ttcgaaaaaa tcatgagcgg acaaagcttg agtattgttt tgtcgtaaca gacggaatcg 1136041 gcattttagc tgttgacacg atcggctaca cgatccctgt cagaaaaagc cgtctaatcc 1136101 caagacagga gcagctcgtt tatgaaatgg taaaagatgt agagcctgaa acatatgaat 1136161 ttgagccaaa gaagctggaa tcctccaagg aatatcacat cttatcatta gcaccagaac 1136221 atgtcagagg actgacaaga aaagaacggc aaattaagca gctgatgttt atggcgcttg 1136281 accaattaaa agggctgaaa aaccgagcgg aaattggcta ctggtacaca gagtggaatc 1136341 cgcatatgta tgaacaaatc aaaaggatga gctttgaaga gatttgggac atgctgtata 1136401 acgaaacaat tgaaggctgg tcggacaaac acctagcttt ttgcgaaaac ctaataaaag 1136461 gacagccttt tttcgaaaag ctttgggaaa tggaaaacga atcaaaggtc aactgaaaaa 1136521 aaccgctctt tgcaaagagc ggttttttga ttagcgtctt tttcttccaa gacccatggc 1136581 attctccatt tttttcagca ttttgtttgc tgtccgattc gctcgttccg cgccttcatc 1136641 aagaatccgg tctaattctt cagattctat cagctcgtaa tagcggtcct ggatcggttt 1136701 taatgcgttc actacgactt ctgccaaatc acctttaaac tcgccgtagc cttttccttc 1136761 gtactttgct tcaagctctt caattgtcgt attgccgagg attgaataaa ttgtaagaag 1136821 gttggaaacg cccggtttgt tttccttatc aaatttgaca atgccttcag aatccgttac 1136881 tgcgcttttg attttctttt caagctgctt cggctcatcc agcaatgtaa tataagcttt 1136941 ctgattcgga tcagatttgc tcattttctt cagcggatca ttcagagaca tgatacgtgc 1137001 accgactttt ggaattttca cttccggaat cgtaaagatg tcgttgtatt ttttgttgaa 1137061 gcgttctgca agattccgcg tcagctcaag gtgctgcttt tgatcctcgc cgacaggtac 1137121 aagatccgtt ccgtacagca gaatatcagc ggccatcagc ggcggatatg ttaacaggcc 1137181 ggagacgaca gcttcattgc ctttggattt gtccttaaat tgagtcatcc gctcaagctc 1137241 gccgatatag gcgacacact gcatcatcca tccggcctgc gcatgtgcgg ggacctctga 1137301 ctgaataaac aatgttgctt tttctggatc aagtccgaca gctaagtaaa gcgccgcgag 1137361 attgcggata ttctttctaa gctcaagccg gtcttgagga acagttatcg catgctgatc 1137421 gacgatgcaa aaatagctgt tataatcatg ctgcagttcg acaaactgct tcattgcacc 1137481 gatatagttg ccgagcgtca ctgagccgct tggctgaatg cctgaaaaaa tcgtttgttt 1137541 catgaaaaca tcaacctcat ttcttaaaac ataataaaaa aggctcattc ttcccctgta 1137601 aaaaagggac gaatgaaccg tggtaccacc ctgattattc cattaaaatg gaatcactct 1137661 gacgtttgta acggagactg ctccggctga gcctactttt ttccagttcg gtcagctgct 1137721 ccaaagtcca ttccacattg cccgttatct gctcccagca ccgcagactc tcttcaaaca 1137781 ggtgaaacgt gtactactct ttttcatagc aagcttttct tttgattgct tcattataaa 1137841 tcaattataa ccaattgtca tcatgaaaaa acattctttt ttccagtaaa attgtaataa 1137901 tataaataac acgagtgctg taaaatcctt aaatgataac tgctatcagc gtaaaaacag 1137961 gcagatatta tatgtaaaaa gcaatatggg cagaaaacac atgaaaaagt ttttaatcaa 1138021 tttatgcttt aaatggtaga aggatattat gttcatggaa gaaaaactaa cgaagtttaa 1138081 atattttaaa ttgataaaat aatattgcaa taaattattt gtttcattat aatgaacttg 1138141 ttcactctat tgttacagct tttttacaaa aataatcaga aaagacggaa cagaataaaa 1138201 gttgtggaaa ctcaggttca tttgtctgat atttctgagg atttagccgt aaggagctga 1138261 aaattattat tagggggttt gcgaatatga aaaaacgttg gtcgattgtc acgttgatgc 1138321 tcattttcac tctcgtgctg agcgcgtgcg gctttggcgg cagcggatca aacggtgaag 1138381 ggaaaaagga cagtaaagga aagacgacac ttaacattaa tattaaaact gagccgttct 1138441 ccttacatcc gggattggca aatgattcag tatcaggcgg tgttatccgt cagacttttg 1138501 aaggattgac acgtatcaat gcagatggtg agcctgaaga aggcatggct tctaaaattg 1138561 aaacgagcaa ggacggaaag acatatacat ttaccattcg tgatggtgtg aaatggtcta 1138621 atggagaccc tgtaactgca caagattttg aatatgcttg gaaatgggcg cttgacccta 1138681 ataatgaatc acaatacgct taccagctct actacataaa aggtgctgaa gcggcgaata 1138741 ccggaaaagg cagcctagac gatgtggcag taaaagctgt gaatgacaaa acgctgaagg 1138801 ttgaattaaa taacccgact ccatatttca ctgaattaac tgcgttctat acgtatatgc 1138861 cgatcaataa gaaaattgca gagaaaaata aaaagtggaa tacaaatgcc ggagatgatt 1138921 atgtatcaaa cgggccgttc aaaatgacgg catggaaaca cagcggctct attactctcg 1138981 aaaaaaatga ccagtattgg gataaagaca aagtcaaact gaagaaaatc gatatggtta 1139041 tgatcaacaa taacaatacg gaactaaaaa aattccaagc tggcgaactt gattgggccg 1139101 gtatgccgct cggacagctt ccgacagaat ccctgccgac cctgaaaaaa gacggttctt 1139161 tacatgttga gccgattgca ggagtgtatt ggtacaaatt caacactgaa gctaagccat 1139221 tagacaacgt caatatccgt aaagctttaa catattcgct tgaccgtcag tcgattgtta 1139281 aaaacgttac gcaaggagag caaatcccgg caatggctgc agtgccgcct acaatgaagg 1139341 gatttgagga taacaaagaa ggatacttca aagacaatga tgtcaaaaca gcaaaagaat 1139401 accttgaaaa aggcctaaaa gaaatgggct taagcaaggc atctgatttg ccaaaaatca 1139461 aattgtctta caacactgat gacgcacacg cgaaaatcgc tcaagcagta caagaaatgt 1139521 ggaagaaaaa tttaggcgtt gatgttgagc ttgataactc agagtggaat gtctatattg 1139581 ataagctcca cagccaagat tatcaaatcg gccgtatggg ctggctcggc gacttcaatg 1139641 atcctatcaa cttccttgaa ttgttccgcg acaaaaacgg aggaaataac gatacaggct 1139701 gggaaaatcc agaattcaaa aagcttctga atcagtcaca aactgaaaca gataaaacaa 1139761 aacgtgcaga gctgctgaaa aaagcagaag gtattttcat tgatgaaatg ccggttgccc 1139821 caatctattt ctatactgat acttgggtac aggatgaaaa cctaaaaggt gttatcatgc 1139881 caggtactgg tgaggtttat ttcagaaacg catattttaa ataaggctac gtctgaaaat 1139941 aaaagacctc aaggtatatg gggagaaaag ccccatatac ctttcttact gatggagtat 1140001 aaaaatgtaa aaaccatgga ggtgttcccc cttgctaaaa tatatcggaa gacgcttagt 1140061 ctatatgatt atcacactat ttgtgattgt aactgtgaca ttcttcttaa tgcaagcagc 1140121 accgggcggg ccattttcag gtgagaaaaa gcttccgcct gaaattgaag caaatttaaa 1140181 tgcgcattat ggcttggaca agccgctgtt tgtacaatat gtcagttatt tgaaatcagt 1140241 tgcaatgtgg gatttcggac cgtcatttaa atataaaggt cagagtgtta acgacctgat 1140301 cagttcaggt ttccccgttt catttactct tggagcagaa gctattctcc tcgctttagc 1140361 gttaggtgta ttgtttgggg tcattgcagc cctttaccat aataagtggc aggattatac 1140421 cgtcgcgatt ttaacgatat ttggtatttc ggttccgagc tttatcatgg cggctgttct 1140481 gcaatatgtg ttctccatga agcttgggct gtttccggtc gcggggtggg attcctgggc 1140541 atacaccttt ttgccttcca tcgcacttgc ttccatgccg atggcgttta ttgccagact 1140601 ttcccgttca agcatgatcg aagtgttaaa cagtgattat atccgcacag cgaaagcgaa 1140661 agggctttcc cgcccagcgg ttacagtgcg gcacgccatt cgaaacgcac ttttgccggt 1140721 tgttacatat atgggcccga tggccgcaca ggtcttaacg gggagcttca ttattgaaac 1140781 catttttggg attccggggc ttggtgcaca cttcgtcaac agtattacaa accgtgatta 1140841 tacggtcatt atgggtgtaa cggtgttctt cagtgtcatc ttgctattgt gtgtattaat 1140901 cgtagatgtg ttatacggca ttattgatcc aagaatcaag ctttccaaag caaagaaagg 1140961 agcctaggcc atgcagaaca ttccaaaaaa catgtttgaa ccagccgcag cgaatgccgg 1141021 cgatgcagaa aaaataagta aaaagagcct ttccctctgg aaagatgcga tgcttcgctt 1141081 ccgcagcaat aagcttgcaa tggtcgggct tatcattatc gtacttatta tccttatggc 1141141 aatttttgcg ccgatgttct caaggtatga ttattcaact actaatctct taaatgcgga 1141201 taagccgcct tcaaaagatc actggttcgg aacagatgat cttggacggg acattttcgt 1141261 ccgtacatgg gtaggggcgc gaatctcaat ctttatcggt gttgcagctg ctgttctcga 1141321 tttgctgatc ggcgtcattt gggggagcat ttcaggcttc cgcggaggaa gaacagatga 1141381 aatcatgatg cgtatcgctg atatcctttg ggcagttcct tcattattaa tggttatctt 1141441 actgatggtt gttcttccga aaggtctatt tacgattatt attgccatga cgattacagg 1141501 ctggattaat atggccagaa tcgtgcgcgg acaagtgctg cagctgaaga atcaggagta 1141561 tgtgcttgct tcacagacac tgggtgcaaa aacatcccgt cttctattta aacatatcgt 1141621 gccaaacgca atgggttcta ttttggtcac gatgacactg acagttccta ctgcgatttt 1141681 tacagaagcc tttttaagct atttgggact tggtgttccg gctccgctgg caagctgggg 1141741 aacgatggct tctgacggat tgcctgcatt gacctattat ccgtggcgtt tattcttccc 1141801 tgccggattt atctgcatta caatgtttgg ttttaacgtt gtcggcgacg gattaagaga 1141861 cgcattggat cctaagttac gtaaataagg gagtgatacg ggtgacacgc ctattagaag 1141921 taaaagattt agcaatttca tttaaaacat atggcggaga ggtccaggcg atccgcggag 1141981 tgaatttcca tctggataaa ggggagacgc tggccattgt tggagaatca ggttccggaa 1142041 aaagtgtaac ctctcaagcg attatgaagc tgattccaat gcctccgggt tatttcaaac 1142101 gcggtgagat cctgtttgaa ggaaaggatc tggtgccgct gtccgaaaaa gaaatgcaaa 1142161 atgtccgggg aaaagagatc ggcatgatat tccaagatcc gatgacctct ttaaatccaa 1142221 cgatgaaggt cggtaaacaa attacggaag tgctttttaa acacgaaaag atctcgaagg 1142281 aagcggctaa aaaacgcgcg gttgaactgc tggaattagt cggtatccca atgccggaaa 1142341 agcgggtgaa ccaatttccg catgaatttt caggcgggat gagacagagg gttgtcattg 1142401 ccatggcgct tgcagcgaat ccgaaacttc tgatcgccga tgagccgaca actgctcttg 1142461 atgtaacgat tcaagcgcaa attttggaat taatgaagga tttgcaaaag aaaattgaca 1142521 cgtccatcat ctttatcaca cacgatcttg gtgttgtggc taacgttgct gaccgggtcg 1142581 ctgtcatgta cgcgggacag attgtagaaa ctggtacggt agacgaaatc ttctacgacc 1142641 cgagacatcc gtacacttgg gggcttcttg catccatgcc gacactggaa agttcaggag 1142701 aggaagagct gactgcaatt ccgggcacgc cgcctgattt gacaaacccg ccaaaaggag 1142761 atgcttttgc cctgcggagc tcttacgcga tgaaaatcga ttttgaacag gagccgccaa 1142821 tgtttaaggt atccgatact cattatgtaa aatcgtggct gcttcatcct gacgcgccaa 1142881 aggtagagcc gcctgaagcg gtaaaagcga aaatgcgtaa actggcaaac acgtttgaaa 1142941 aacctgtctt agtgagagaa gttgaatgaa ttgactgaaa aactattaga aatcaaacat 1143001 ttaaaacagc actttgtcac gccgagggga acggttaagg ctgtagatga tttatcattt 1143061 gatatctata aaggtgaaac attagggctg gttggtgaat ctggctgcgg taaatcgaca 1143121 acaggccgaa gcattatcag gctgtacgaa gcaaccgatg gtgaggtgct gttcaacggc 1143181 gaaaatgtgc acgggagaaa atcgcggaaa aagctgctgg aattcaaccg caaaatgcag 1143241 atgattttcc aagaccccta tgcatccctg aatccgagaa tgacagttgc tgatattatt 1143301 gctgaaggcc ttgatattca taagctggca aaaacgaaaa aagagcggat gcagcgagtt 1143361 catgaactat tggaaacagt gggattgaac aaggaacacg cgaaccgcta tcctcatgaa 1143421 ttttccggcg gccagcgcca aagaatcggg attgccagag cgcttgctgt tgatccggaa 1143481 ttcattatcg cggatgagcc gatttccgct ttggatgtat ccattcaagc gcaggtcgtg 1143541 aatttaatga aagaactgca aaaagaaaaa gggctcacat acctgtttat tgcccacgat 1143601 ttatcgatgg tcaaatacat cagtgaccgc attggcgtca tgtatttcgg gaaactggtt 1143661 gagcttgcgc cggcagatga gctttatgaa aatccgcttc acccatatac aaaatcattg 1143721 ctttctgcga ttccgcttcc tgatccggac tatgagagaa atcgcgttcg ccagaaatat 1143781 gatccgtctg tccatcaatt aaaggatggg gaaacgatgg aattccgtga agtcaaaccg 1143841 ggacattttg tgatgtgcac ggaagccgaa tttaaagctt tttcatgatt catcaatcct 1143901 tcaagagatt tctcttgaag gatttttttg cgtcttcata gaaagtgaga atgataacat 1143961 ttacaattag aggaaaaagc ggaggcgaaa tacgattcaa tttctgcata acaaaaatgt 1144021 ttttgcgcta ttgctgtctc aatcttttca atctttagca ggagtcctcg tcacaatcgt 1144081 tttaatggtc cggatctatc aaatgactga ctccgttttt ttggcgggcc ttattttatc 1144141 gttcatgtcg tttgcgagta tagcagcaag cttttgcgtc tctccggtgc ttcgcattct 1144201 cggttttaaa aaggtgcttg cgggagcgaa tctgctgaga gcggtcttta ttatactgat 1144261 ggcatacagc gtcactcatc acggacaggc attcttttgg attacgctgc tgtttgtgtt 1144321 ttgtttttcc ttcgcgggcg ctttttttca gccggcaaga tttgcgctgc tgccgattat 1144381 tgttccaaag aagcaatatg taaaagcgaa tggtgtgatc tccctctcga atcaattgtt 1144441 cttaacagca ggctggggcc ttggaggcct tctgacgtac gccgtccctt ttgaactcgt 1144501 tgtcggcgct gccatttgcc tgtttgttct atcgggagct tccatcagtg tgctgcatgt 1144561 aaatgaagaa gaggctgcag gaactgctga aacagcatct gtcagaagta tatggaagga 1144621 tttaatgatc atccctattg taagagacat tactgtaatg gacatgttag aagctttggc 1144681 gggttccgta tggtcatctg ctattctcct cgcatttact gcggctgttt tgcatgaaac 1144741 agaggtgtgg tgggggatgt ttaacgcttc ctattttata ggcgcaattg tcggcagtgt 1144801 gattgctatt cgtttttctt ctttttttga gcggaatatg ggctatgcca ttatgttcag 1144861 ctcgcttgta atgtcggcgc tgaccctttt gttttcattt tctccagtcc catttttatg 1144921 cgctctggct tgtgctgcaa tggggccttt ttatcaggtg cgtgatattt gccaggaaac 1144981 catgctgcag gaagttattc ccgagcagaa acgaatcgga atcatggctg caaaaaatgc 1145041 gattttgact ccttggtcag gcgtcaccta ctccattatg gggctagtgg ctgatgctgc 1145101 tggtgcgaaa atagctttta tcgcggctgc tgcattatat atcatgacat ttctgattgc 1145161 actggcgcag ccccgtctgg ttcattacag gcgagaaaat cgagttcaat gagaaacact 1145221 tcaaaatgaa cggagcagct ggctccgttt tgctgaaaaa aaaatgaaac catggcggaa 1145281 gttcgcacgt ctttatagat gtaaggctgt ttaaacaaga agaaatgggg tatatctaaa 1145341 agtatgaaga caacgaactc ataaggagca aatcaatgaa ctggtatgaa aagcttagcg 1145401 agtactttcc aattgaagaa atgaaatcaa aagcgcatat ggaagctctt ctgaaagagc 1145461 gaagcgatat ttatcataaa gatgaaggca aacatcatat tttaatgttt gcggaattcg 1145521 attcttttat cttcgttgat tatctgtatg tgtctaagga tgcaagaggg caggggcttg 1145581 gcggcaaatt gatcgcgaag ctgaaaaaga aaaataagcc catattgctc gaggtggaac 1145641 ctgtggatga agatgatact gatacagaaa aacgcctgag gttttatcaa agagagcatt 1145701 tcaagcatgc tcagtcaatt gggtaccggc gccggtcatt ggctacgaat gaagtaaaca 1145761 agatggagat tctgtactgg tcaccaaaaa cagaatcaga agaagaaatt cttgaagcca 1145821 tgaaacagac atatgaaaac attcatactt ataaagatga gaaatggtac ggagaatcgt 1145881 acgaaaaaac ggatgaggtc ttggaaatca tcgatgaaga aaaacaaaaa aatattttcg 1145941 atcagttaag ctaattgaga ataagaacat atcatgaaca ttaaaaattt gctggattga 1146001 cacatttttt tcttaggata ctgttcacac ttactttttt atagtataat acctgtaaag 1146061 attccttttt tagagtaatt tcaatttaag aataaaatag atgttcatcc tactaattag 1146121 aggagtgaag atgaatggtt acactataca catcaccaag ctgtacttca tgcagaaagg 1146181 cgagagcgtg gctcgaggag cacgagattc catttgtaga aagaaacatt ttctctgaac 1146241 ctttatcaat tgatgaaata aaacaaattc ttcgaatgac tgaggacgga acagatgaaa 1146301 tcatctcaac ccgttcaaaa gtattccaaa aactgaatgt gaacgttgaa tctatgccgc 1146361 tgcaagattt gtaccgcttg atcaacgagc atccaggttt gcttcgccgt ccgatcatca 1146421 ttgacgaaaa acgtttgcag gtcggatata acgaagacga aatcagacgt ttcctgccaa 1146481 gaaaagttcg ctctttccaa ttaagagaag cacagcgttt ggcaaactaa tagatcgtat 1146541 catcaaaaga aggctgagtc atcagccttc ttttattttt caacctgctg gtaataaatg 1146601 ctcgcaagga tgacaaacgc aaccgtcaaa atggggagga gcgtttcgac tgtgccgtgc 1146661 tgcgccataa aaagcgacag ctttttgtct ctgacaatca tttctccgcc agtataagca 1146721 agcagcccgc ttcccgcgta aatcagaagc ggtattttct ctagtgcaat atggatgagt 1146781 ttgctgcccc aaataataac cggaaccgat acacacaatc ctataacaac gagagaaaac 1146841 tcaccgtgtg aagctcccgc aactgcgatg acgttgtcca gcgacataaa gagatctgca 1146901 agcacaatcg ttcgtatcgc tctccacagg gaggtgctgc ttttaatgtg tttcgtgtct 1146961 tttttttcaa tcagcagctg atatcctaaa tacagcagga aaattccgcc ggcgcactgc 1147021 aagaacggaa tgttcaaaag atatactgct gcacttgtta atccgattct catggcaacg 1147081 gcaataaatg ttccgagaat aatggcttgc tgtctttgct tgtccggcaa atgtctgctg 1147141 gccatggcaa taacaaccgc gttatctccg ccgaggatca ggtcaatccc aacaatgacg 1147201 agcagagaaa tcagatagtc atgctccatg aagcggcacc tcgctttcag tccttcgctt 1147261 gtactactac tatatgagac aggtcatatt ttatgatatc agccgcctga tctgccgttt 1147321 tttaggcaaa ggtgcatttt tatttctttt gtgactgttt tatcataaaa tagaaataca 1147381 aaggaattca cactggcctt ggttaaggtt aagatgtgga cggaatgggt aaagtgtagt 1147441 aaagtacaat taatcgggag cttagatgtc ccttcaacat cttatataga agggaaggtt 1147501 ggcaaatgga aattgaaaga attaacgagc atacagtaaa attttatatg tcttacggag 1147561 atattgaaga tcgcggtttt gacagagaag aaatttggta taaccgtgag cgcagtgaag 1147621 aacttttctg ggaagtcatg gatgaagttc atgaagaaga ggaattcgct gtggaaggcc 1147681 cactttggat tcaagttcag gcactggaca aaggattaga aatcatcgtc acaaaagccc 1147741 agctttccaa agacggacaa aagctcgaac tgccgattcc tgaggataaa aagcaagaac 1147801 cagcatctga ggatcttgac gccttgctgg atgatttcca gaaagaagag caagccgtca 1147861 atcaggaaga gaaggagcaa aagcttcaat ttgtcttgcg atttggcgat tttgaggatg 1147921 ttatttctct atctaaattg aacgttaacg gaagcaaaac gactttatat tcgtttgaga 1147981 accgatatta tttatatgta gatttttgca atatgactga tgaagaggtt gaaaatcagc 1148041 taagcatcct gctggagtac gcaactgaat cctcaatcag catacaccgt cttgaagagt 1148101 acggcaagct gattatttca gagcatgctc tagaaacgat aaaaaaacac tttgcatcat 1148161 agcaaaccga tttccttccg gaaatcggtt ttttttatgc acgaaaatgc cattttagag 1148221 atgtgaaaaa tcaaaaacat atagacaagc agaaaataca gcgaacagga gttgatcatc 1148281 ttttccagaa agtatacttc atctggaaag gagagatgac aattgtttag tgctgtgact 1148341 gaagacggcc aaatgtttca ccttctaggc gctcagcaaa accagaaatt aaagcggaga 1148401 cggttcttct gtccggtatg cgggggagag ctagctgtga agctcggact tcaaaaagcg 1148461 ccgcattttg cccataaaca gaacaagtcc tgcgccatag acatcgagcc ggaaagcgcc 1148521 taccacttag aaggaaaaag acagctgtat gtatggctga aaacgcaacg ggcttcacca 1148581 atattggagc cgtatataag gacaatcaac caaagaccgg acgtcatggc aagaatcaag 1148641 gagcatatgc ttgctgttga atatcaatgc gccactatcg ctccagatgt ctttcaaaag 1148701 cggacagagg gcttcaaaca agaaggaatc atcccgcagt ggattatggg atacagccgc 1148761 ttaaaacgga ctgcttcgtc cttttatcag ctttcaactt ttcattggca gtttatcaat 1148821 gcaagtccat acagagaact gatatgttat tgtcctgaaa ggcgttcttt tctccggctc 1148881 agccacatca ttccattcta cacaaaccat tcttattcct cagtccaaac gatccctatc 1148941 catcgggcag gtgcaggcga tctttttttc actgaaccga aaccctcaat tcaatattca 1149001 ggctggacga aagcgattca ccgttttcgc cataaacccc atcggtttaa ctcaaaggaa 1149061 acaaatcgcc ttaggctgct gttttatgag aaacgacaga cgcctttttc ttttctgccg 1149121 actgaagtgt ttgttcctgt tagaaaaggg gcagttttta agagtccggt ttttgtgtgg 1149181 caggggtttc tttatttgtt tatgacggat cttggaggta aacgtgcgcc aattcgtttt 1149241 tcagccgttt tgcagcagtg caaactgcac attcataata agaacattgc actcaggtcc 1149301 gaatgcagcg aagagtgtct ttcagaagcg gttaaacagt atattgattt tttgtgcaag 1149361 aagggatttt taagggagac tcagaaagaa gtatatgtgc tgaatcagcc tgcaggaggc 1149421 atacactcca tgcaggatct catagaaaga gaccgcagct gttttataga atgagtttgt 1149481 cttatttggc tcaccctaag acaaaggtgg tgggcaggct gtgaaaggca caaaaggaaa 1149541 ggtttttcgt gtttttactg cttttttggc attcgttctc ttcattactg catatgattt 1149601 gacaaaaggc agtgaaaaac cggaagatat tcacaacaca agtttattga gaaacagctg 1149661 ttttttcaat tggcttgaat caaagaagac gagggggatc accatggctg aggaaaaaaa 1149721 agcaaaccaa ctgcctgaca gaagtgaggt aaaggcagaa gacacatgga gacttgagga 1149781 tatttttcct agtgatgagg cctggaataa agaatttcaa gctgtaaaag aattaattcc 1149841 gaatttatct aagtataaag gaaagctggc agattcagct gatcatttat acgaggctct 1149901 tacgtatcaa gataaagtga tggagcggct aggtaggctg tacacatatg cgcatatgcg 1149961 ctctgaccag gatactggga actcctttta ccaggggctg aatgacaagg cgggaaacct 1150021 gtatacacag gccgcaagcg cgacagctta tttggttccg gagattttat ccatagaaga 1150081 agacaaactg cagcagttca ttcttgaaaa agaagaattg aagctgtact ctcatgcgat 1150141 tgaggagatt acaaaggaac gtccgcatgt gctgagcgag aaggaagagg cgctgcttgc 1150201 tgaagcctcc gaggtactgg ggtcatcttc aaatacattc agcgtgttaa ataacgcaga 1150261 tataacgttt ccatccatta aagacgaaga tgggaatgaa aaacagatca ctcacggcaa 1150321 ctttattaat ttcttggaaa gtgaaaaccg tgaagtccgc aaaaatgcgt ttgacgcagt 1150381 gtataaaacg tacggacaat ataaaaacac aatggccacg acgctaagcg gcactgtgaa 1150441 aaaggacaac ttctacgcga gagtgaaaaa gtacaagtcc gcgcgtgagg ctgcgctttc 1150501 taacaacagt attcctgagg aagtatacga taaccttgtt aagacgatta ataagcattt 1150561 gccgctcctg caccgctata ttgcgctaag aaagaaagtg cttgagcttg atgaagtgca 1150621 tatctatgac ctgtatacac cgcttgtgaa agatgctggg atgaaggtga catacgagga 1150681 agccaaagat tacatgctga aaggcctcgc acctttaggg gaagaatatg cctctatcct 1150741 aaaagaagga ctggaaaacc gctgggtgga cgtttacgaa aataaaggca aacgcaatgg 1150801 ggcttattca tcaggagctt acggcacgaa tccgtatatt ttgatgaact ggcataataa 1150861 cgtcaataat ctctttacgc tcgtgcacga gtttggacat tccgtacaca gctactatac 1150921 gagaaagcac cagccttatc catacggcaa ttacagcatc tttgtcgcgg aagttgcctc 1150981 tacgacaaat gaagcgctcc ttggcgaata tttgctgaac aatttagagg atgaaaaaca 1151041 gcgcttatat attctcaacc atatgcttga gggcttcagg ggaacggtct tcagacaaac 1151101 gatgttcgct gaatttgaac atctgattca tacaaaggcg caagaaggcg agccgcttac 1151161 acctgagctt ctgacaaatg tctattacga cctgaataaa aagtattttg gagacggcat 1151221 ggtgattgat aaggaaatcg gccttgaatg gtcgcgtatt ccgcacttct attacaatta 1151281 ctatgtgtat cagtatgcga caggttacag cgctgcccaa gcattaagca gccagatttt 1151341 gaaggaagga aagccggcgg ttgaccgtta tattgacttc ctgaaagcgg gaagctcaca 1151401 atacccgatt gatgtcctga aaaaagcggg tgttgatatg acgtctccag agccaatcga 1151461 agccgcgtgc aaaatgtttg aagaaaaact tgatgaaatg gaagagctgc tgatgaaagt 1151521 caagcagtct taaaaaagta agcctgtgcg gaaatgacgc acaggctttt ttaaaaccct 1151581 ttaaaggttt tccggtgatt caagcggtag agggtaaaca aaatagacag aaacagcaga 1151641 ggagaggtaa tataaagcgg cagcatatgc atcatgccta agatattcaa gcagaaaaaa 1151701 acagcaatgc acacaattga gatcaaagta gacatcatgg cggtcctcct cgtccttttt 1151761 ccttataagg atatgagtga atgcacttcg ttatgttttg tgacaaaaat atgaacatta 1151821 agcatagagg ttgtcaaaag tcgacatctt ttgttatcat aaggatgtga aattgatcac 1151881 aaacaaacat tacccctttg tttgaccgtg aaaaatttct cccatcccct ttgttgtcgt 1151941 taagacatat gaaaccgcgc ttatcccggc gcggtttctt tagtgctaaa aatggaacgt 1152001 acgtttggtt atggcataaa aaaacagcct caagcatatg cacgcctgcg gctatttttc 1152061 acatgattga tattcatcag aataagtgct gagagacttc caaaacattc cgtgtttggc 1152121 ttccactttg gcaacctttt tagcaaacgc cagttttttc atttcttttt ctacctcttc 1152181 aaggctcagg tcatatacaa gagcaatttc cttcgaggca acgaagcgga aatattcaat 1152241 aaaacattct aaaggcggtg tttccgacgg cttcggctcg tcgccaagca tctcaaataa 1152301 aatttcttca tatacatcat atgagtagct gccaggaact ttaagccctt catcctcatg 1152361 ctgcgtatta aaaaacgtca gtgtcggatt aacagaaaca tccatctcgg cagcaatttt 1152421 catgtcacat tgaagcgcct tgaccgcgct ttgagaatgc agatcttttt tgaattcttc 1152481 aagatcgaga cttgtatttt cagcaatctc caaaagcacg ttttcatccg taatattttt 1152541 ctttgaaaca aataggctct cctgcatatt tctgagaaat tgcatgccgg cttttcgtcc 1152601 ttgcagttcg gctgctttaa aagcgagagc agccatataa ggcgatgaaa gcggctgatc 1152661 ctgttcgaac cagacattgc cgtcacatga catgccagag cggctcgcga tcttttccca 1152721 tgcttctgcg agaagatgct tttttcgctt tttatttaaa gcggtaaggc ttgcggaagc 1152781 gataatgcgt aaggtgaaaa aacgtccgta tctgattttc agctttttga tgacgggctc 1152841 taaggaccag cattcaggac ataaagggtc tacaaacata taaatttcaa gcggtttttt 1152901 tggatgaccg tggcaatggg cgaagtatag ctcatgctga tagtttgtca agatgatcga 1152961 tcctccgctt ccgtttgatt caccatatgc cttgctgtca actccagccg gccaaacaaa 1153021 aactcacgaa tttcgccctc cagccctaca tggtccattg cgtccttcat acagctgagc 1153081 cacgcatcag ctctctcgtt tgtaattgga aagggaagat gccttgctct gagcatagga 1153141 tggccgtgtt cctcagtata aagaggaggc ccgcctaaat actgagttaa gaattgcttc 1153201 tgtttcctgg cggtttctgt caaatcgctt ggaaaaatcg gcttcagcaa aggatgagac 1153261 gcgacacgct cataaaaagt atcaacaagt tgcgatagaa gttcctctcc aatcgcttca 1153321 taaggtgcgt taaacgattg tcccatgttg actactcctt taaatatggc taataggaat 1153381 cataaatcct attgcaaaaa gtaattttct gtatttcatt gtttcatcta gatttatttt 1153441 agcaacaagg catcatttct acaaacaaac tgccttttat gcgtttgatg actcatttcg 1153501 gctgacagcc ggggtttgta tttcatatca tatcacataa aaatcaggaa tgcgtaagat 1153561 ttcacttcgc aaaaaaacca gagggaaaga gcacctctgg ttacgcgtaa taaactgaag 1153621 ttattttttt tacatagttt tgcgtttctt ggaaaggagg aatgcctccg tatcggtcaa 1153681 cattccccgg tccggcgttg taagccgcta atgccataga cacattgccg tcgtatttat 1153741 ccagcatttg ttttaaatat ttcgttccgc cctccacatt ttgctgcgga tcaagcggat 1153801 tggaaacgcc aagtgagctt gctgttgacg gcatcagctg catgaggccc atcgcacctg 1153861 ctccgctgac cgcttttgca ttaaagcctg attcctgttt gatgacggcg cggatcagtt 1153921 tttcatcaac gccatattta tcagcggctt ttttaatcgc actgtcaata gagaagtctc 1153981 ccgaacggat ctgatttgct tcatgtttgt ttgaagctga atctgcaaca gctgtttcag 1154041 tgctttctgc cgcttttgtg actgaacctg aattgctgct cgtatatgag ttaagcccat 1154101 acgctgaaag cagtgacggc gctgttgtat tcgcgctgtt cagcatgctg agcgggcttg 1154161 gcgatgaaga aggtgctgat tgctgagatg tcagaccgtt tgtatattgg ctgagcaaag 1154221 aactgaaact tgaaagcggg ctttccgtat tctgagtgtc cgagctgctg cgtgcattag 1154281 atatggactg taatgcctga agctgaagta atgctgccca attcgttaca ttcacgatgt 1154341 cattccacct tatatagact ttcgtttttc ttcataaaaa cgcagaattt tatttttggt 1154401 ttcgcgctga ggaatgctga attgctgaag cagcttttcg aaggcttgtc tgccctcatg 1154461 ccaatccgcc gcctcaaatt caatttcata gtcctcttta tttaaatatc ggctgtggtc 1154521 taaaactatt aagccttttt ctgtttcttt ttccgcacgg tttgttgcta aagatccaaa 1154581 gtattgtatg gcatccgtat cgatctgaag cttgtgcagc tggtccttca cagggccctc 1154641 gggaactgaa aatccagcga gatctgatac ctctgaaagc tgctggtgcg tttccagaag 1154701 ccccacatca gccggctcct ttaatgtaag gacatacttt ccgttttttc tgcggatacg 1154761 aagcgcagca tgtttttgtt tcagcgcgaa gctgtctgta tcaaaataat gattcttttg 1154821 atctgtaaaa tctttttctg tcagctggag tgccgatgct atgtttttga attcttgttt 1154881 ggtcagcatg tttttaaatt cgatttcaat ctcttggctc atgatgctct tcctttccgc 1154941 cctgtaaatc ttatttttac tattatctct ttagatgtta ggtttatcaa tatcgagctc 1155001 gatatgataa aatgaatctg tactttgttt aaaaaaggag agcattatgc aaaacagaat 1155061 cgaaattttg aatgcaacat tatcggatga tcagcttcgc cttgcctgtc agacagaagg 1155121 aaacgaagcg gaacgcaagc cgtcaggtca aatgcttgtt gattctgacc actttgcttt 1155181 tgtatacata cttgaattag ctgattcttt tgaatatgtc attataaagg aacatgtatg 1155241 gccggaactg aagcaggccc atgcacaaaa aataccggtt gttttagagg caggagacca 1155301 aacaattgaa ctggcaggcc tgcatgagga gctggaatat cttttagaaa atataaaaga 1155361 taatgcaaac tatggagaag aaatggaaga aaaagtgaaa cgcgtgtttt tatagaaact 1155421 ggttcggaat tgggggatgt atgatggatg acaaacaatg ggagcgtttt ttagtgccgt 1155481 accgccaggc tgtcgaagag ttgaaagtga agctcaaggg gatccgcaca ctatatgaat 1155541 acgaggacga ccattcaccg atcgaatttg tgaccggacg cgtcaagcct gtggcgagca 1155601 tacttgaaaa agcgagacgg aaaagcatac cgctgcatga aattgaaacc atgcaggaca 1155661 ttgctggcct tagaatcatg tgccaatttg tcgatgacat ccaaatcgta aaagagatgc 1155721 tttttgccag aaaagatttc accgttgtgg atcagaggga ttatattgcg gaacataaag 1155781 agagcggata ccgatcatac catcttgttg tgctgtaccc tttgcagacg gtatccggag 1155841 aaaagcatgt tctcgtagaa atacagatcc gtacactggc gatgaatttt tgggcgacca 1155901 ttgaacattc attgaattat aaatacagcg gaaacattcc tgaaaaagta aaactaaggc 1155961 ttcagcgcgc ttctgaagcg gcttcccggc ttgatgaaga gatgtcggag atcaggggtg 1156021 aagtacagga agctcaagct gccttttcaa gaaagaaaaa aggaagcgag caacaatagg 1156081 taaaggggaa gaagagcatg aaatttgccg tatcatcaaa aggagatcaa gtttctgata 1156141 cgctgaaaag caaaatacag gcgtatttat tggattttga tatggaactg gatgaaaatg 1156201 aaccggaaat cgttatttca gtcggaggcg acggaacgct tttgtatgct tttcacagat 1156261 acagcgaccg tttggacaaa acagcatttg tcggcgttca cacaggtcat ctgggttttt 1156321 atgccgactg ggttcctcat gaaattgaaa aacttgttct tgccatcgcg aaaacgccgt 1156381 atcatacagt cgaatatccg cttctcgaag tcattgtgac ctatcacgaa aacgagcggg 1156441 aagaaagata cttagctttg aatgaatgta cgattaaaag catcgaagga agccttgttg 1156501 ctgatgtgga aatcaaaggg cagctctttg aaaccttccg gggcgacggc ctctgcctgt 1156561 caactccatc aggcagcaca gcctacaata aggcgctggg cggagcgatt atccatccgt 1156621 ctatcagggc gatccagctt gcggaaatgg cttcaattaa taaccgcgtg ttccgtacgg 1156681 tcgggtcacc tctgcttctc ccatcccatc atgattgcat gattaagccg agaaacgaag 1156741 ttgactttca agtgacgatt gaccatttaa cccttctcca taaggatgta aagtcgatcc 1156801 gctgccaagt tgcatccgaa aaagtgcggt ttgcgagatt ccgtccgttt ccattttgga 1156861 aaagagtcca ggattcgttt attggaaaag gtgaatagaa agaggacata tcgtggagca 1156921 tttttttatc agaaagaaca ttacttccgc tgaggacggg atgactgtaa aagaatatgc 1156981 cggtgaactg ggaatttcga aacgtctgct gaccgatatt aagtttggcg ggggagacct 1157041 gcagattaac ggtgagcatg tgacggtcaa atacgttttg aaagagggag atcttcttat 1157101 cgtgaagttt cctgaggagc aggtgagcga gacgctgttg gcagagcctg ttccgctcga 1157161 tatcctttat gaggatgaac atgtgcttgt gataaacaag cagccgtatg tgtcatcaat 1157221 cccttcgaga gagcacccct ccggcagcat tgccaatgga attattgatc attatcaaac 1157281 aaccggagtg agggcgacag ttcatcttgt cacccggtta gaccgggata catcaggtat 1157341 catgcttgtt gccaagcatc gatttgccca ctccatttta tcgtctgcgc aaaaaaacgg 1157401 ccttgtgaaa cgccggtatg cggcagtggt tcacgggcgg atggcacaga tggagggaac 1157461 agtcgatgct ccgattggca gacatcctga cagtattatt gaacggacgg taacgccaga 1157521 cggccagaag gctgttactc atttttacgt cacatgtgca aatgatgaca tgacctcggt 1157581 ggcattgcag cttgagactg gacgaaccca tcaaattcgt gttcatatga gctatctcgg 1157641 gcacccgttg tgcggcgata cactgtacgg cggaacgaga caggaaattg gccggcaggc 1157701 tctgcacagc gagcatcttt cgtttatcca tccgctgaca caggagaaca tgaggtttca 1157761 tgctccactg cctcaggaca tgagcaaact gataaaagga gagaatcatt gattctctcc 1157821 ttttttatat ggggcgaaat cttgattcgt cgtaaggcag ggagcttgga acagagacgg 1157881 tttctatttc tggaaagcga aagcctgtca gttgatttcc gaacacgcag cctgtatcaa 1157941 tgttgatggt gcgattgacc ttccgaggct ctttcacagg tgtatgaccg tataccaccc 1158001 aagcctttcc gttataggct gccgcccaat cacgcctgat gggtctgccg tccggatatg 1158061 tttcacccgt cacgtcaccg taaagcacaa agtccttcac tctgcgggta tatttgccga 1158121 tatcgtcagc tcttatgcca gcatgggcga caactaattc tccattatgt aagatgtcgt 1158181 aaagcggcgc tgtttcgtac agcttcataa actgttcgct gactgatttt ttctcatctt 1158241 tggaaagttc ctcaagctct gccgctgttg tttcgagacc atgcatcact tttaccggat 1158301 ttccttttaa gtaacgatat aatttattgc aatggtttcc cgggacataa cgcacagcgc 1158361 ctttttcgta agcgccggct acaaatcgga tgacctctat cgatttgggc cctctgtcag 1158421 ttaaatctcc ggcaaaaaca agcaccctgc cttcttcatg gacaggtact ccatttttga 1158481 ttgtatagcc aagcttttgg attaatgcag tcatttcgtc atagcagcca tgaatatcgc 1158541 tgatgatatc gtaagccatg cggtctcctc cttaccgatt gttttattta ttatgaagca 1158601 aagtgttgtg agtcatcaca agcttttatg tgcaaattat agaagaagaa tcattttcta 1158661 aacaggatta agaccttatc actttatttt tcatcatcac ccttgttaaa atcgcgttat 1158721 gttttttaaa aatgaggttt tgttctctga gtgagaacta gcataaccct gacttaaaaa 1158781 ggaggttctg attatggcgc atacatctgt cgcatcttta gttgttgtac ttatcgttgc 1158841 atttttgaca cccatccttt tgcatcggtt taaactcagc atcccggttg ttgttgctga 1158901 aatcattatg gggctgataa ttgggaaaag cggccttaat ttagttgtgg agggtgacac 1158961 ctggctccag acactctcta tgctcggatt tatcttttta atgtttttaa gcgggcttga 1159021 aattgatttt tcgtcgtttg agaaaggaaa gaaaaagcag ttcctgccga atggcaagga 1159081 agcgccgaat acgtttgctg cggcatctgt tattttcgtc ggtattttta ttttatcatt 1159141 gctcttgtcc tatgggttcg tcttggccgg atttatccaa aatgcatttt tgatgaccct 1159201 gattatttca acgatttcat taggcgttgt cgttccaaca ttaaaagaag aacggatcat 1159261 gaattcgaat atcgggcaga ttattttgct tgttgctgtt attgctgatt tggccacgat 1159321 gattcttctt gctgtttttt cttctttata cggagaggac agcggaaaca tgtggctcct 1159381 gatgattctg tttgcggccg gagtggtgct ttactttttc ggccgggtct tcaaacatcg 1159441 ctcttttgtt caatccatgt caaaagggac gatccagatc gggacgcgtg ccatttttac 1159501 gttaatcatt gtactcgttg ccctgtctga atcacttggg gcggaaaata ttctcggcgc 1159561 tttcttagcg ggggttcttg tttccctgct ttcgccaaac aaagaacttg ttcagcagct 1159621 ggactcattc ggttatgggt tcttaatacc gattttcttc gtgatggtcg gtgtgaagct 1159681 tgatatttgg actcttttcc aggataaaac aattttaatc atgattccgc tcctgctgct 1159741 tgcgctgtta gtcagcaaaa tcattcctgt catgtactta aagaagtggt atgataaccg 1159801 aaccattttc gcgtctggtt tcctgctgac atcaacgctt tcgctcgtga ttgctgctgc 1159861 aacaatcggc cagcagcttc acgtgatcag tacaaatatg tcaggagcgc taattttagt 1159921 agccgtcatt gcaagtattt ttacgccgat ctgttttaaa aaattataca aacgggaaga 1159981 gcagccggag gagaaaaaga cgattacgtt cattggcgcc aatcaaatga ctttgcctgt 1160041 cacactcgaa ttgccagagg aagagtatga cgtgcgtgtt gtacacgtct accaagagaa 1160101 tgcggaggaa aagctgtcag aatcagtgtt tgctgttgaa acaatttctg actatgaaca 1160161 cgagacgctt gaatcactcg gcatttttga aacggatatc ctcgttgtgg cgacaggaaa 1160221 tgaagatatg aatgcagaca ttgcattact tgcaaaagat aaaggcacag aaagagtcat 1160281 tgcaagcgta ggatcaccgg agcatgaagc agctctgaag gagcagggaa tcagcatctt 1160341 ttctattctg ctgtcgacaa aaacgctgct tcgcgcactg attgaagcgc ctggcgtcat 1160401 gaagctgctc acgaaccaag agtcttcgct gtatcaaatt aatatggaga acagtaaata 1160461 tgatggtgtc attttacggg aattcccttt aacaggtgac gtcatctttg tcaggatctt 1160521 cagaggtgtg gacagcatcg ttcctcatgg ggatacgagg ctgaaacttg gagaccgttt 1160581 aattgtcacc ggatctcggg ggtacgtaac ggatcttaag aaaacattgg aaggataaat 1160641 cttgaccaaa taaggattcg tgttaatata gaggtgcaga acaattcaat atgtattcgt 1160701 ttaaccacta ggggtgtcct tcataagggc tgagataaaa gtgtgacttt tagaccctca 1160761 taacttgaac aggttcagac ctgcgtaggg aagtggagcg gtatttgtgt tattttacta 1160821 tgccaattcc aaaccacttt tccttgcggg aaagtggttt ttttattttc agagggggaa 1160881 tgatttgtga agttttcaga agaatgccgc agtgcagccg cagaatggtg ggaggggagc 1160941 tttgtccatc cgttcgttca aggaatcggt gacggaacgc ttccgattga ccgttttaaa 1161001 tactacgtac ttcaggattc ctattattta acgcattttg caaaggtgca gtcatttggt 1161061 gccgcttatg cgaaggatct ttatacaacg gggcggatgg caagccatgc ccaaggtaca 1161121 tatgaggcgg aaatggcgct tcatcgcgag tttgccgagc tgttggaaat cagcgaggaa 1161181 gagcgtaagg cgtttaagcc gtctcctacg gcgtactctt atacatccca tatgtaccgt 1161241 tcggttttga gcgggaattt cgcagaaatc ttagcggccc tgctgccatg ctattggctc 1161301 tattacgagg ttggtgagaa attgctgcat tgtgatccgg ggcatccaat ttatcagaag 1161361 tggattggca catatggcgg tgattggttt agacaacagg tcgaggagca aatcaaccgc 1161421 tttgatgagc tggcggaaaa cagcacggag gaagtgcgtg ccaagatgaa agagaatttt 1161481 gtcatctcca gctactatga atatcaattt tggggaatgg cctatcgaaa agaaggctgg 1161541 tctgacagcg ccataaaaga ggtggaggaa tgtggagctt cacgccataa cggatgacag 1161601 caagccggta gaagagctag cgagaatcat cattacgatt cagaatgaag ttgattttat 1161661 tcacattcgg gaacgctcaa aatcggcggc ggatattttg aaactgctcg atcttatttt 1161721 tgaaggcggt atagataaac gaaaattggt gatgaacggg cgcgtggata ttgcactttt 1161781 ctctactatt caccgcgtgc agctgccaag cggcagcttt tcaccgaagc agatcagagc 1161841 cagatttcca caccttcata tcgggaggtc ggtgcattca ctggaggaag cggttcaagc 1161901 agaaaaggaa gacgcggact acgtgctgtt cggccatgtg tttgaaacgg attgcaaaaa 1161961 gggtcttgaa ggcagaggag tatctttgct gtcagatatc aaacagcgga tttccatccc 1162021 ggttatagcc atcgggggga tgacgccgga caggttaaga gacgtaaaac aagcaggggc 1162081 agacggcatt gctgttatgt caggaatttt ctcttccgct gaacctttgg aagcagccag 1162141 acgatattcc cgcaagctaa aggagatgcg ctatgaaaag gcattatgaa gcagtggtga 1162201 ttggaggcgg aattatcggt tccgcaattg cttattattt ggcaaaggaa aacaaaaaca 1162261 ccgcattgtt tgaaagcgga acaatgggcg gcagaacgac aagtgccgct gccggaatgc 1162321 tgggcgccca tgccgaatgc gaggaacgtg acgcgttttt tgatttcgct atgcacagtc 1162381 agcgtctgta caaaggtctt ggagaagagc tttatgcatt atccggtgtg gatatcaggc 1162441 agcataacgg cggtatgttt aagcttgcat tttctgaaga agatgtgctg cagctgagac 1162501 agatggacga tttggactct gtcagctggt attcaaaaga agaggtgtta gaaaaagagc 1162561 cgtatgcgtc tggtgacatc tttggtgcat cttttattca ggatgatgtg catgtggagc 1162621 cttattttgt ttgcaaggca tatgtgaaag cagcaaaaat gcttggggcg gagatttttg 1162681 agcatacgcc cgtcctgcat gtcgaacgtg acggtgaagc cctgttcatc aagaccccta 1162741 gcggagacgt atgggctaat catgttgtcg ttgccagcgg ggtgtggagc ggaatgtttt 1162801 ttaaacagct tggactgaac aatgcttttc tccctgtaaa aggggagtgc ctgtccgttt 1162861 ggaatgatga tatcccgctg acaaaaacgc tttaccatga tcactgctat atcgtaccga 1162921 gaaaaagcgg aagactggtt gtcggcgcga caatgaagcc gggggactgg agtgaaacac 1162981 cggatcttgg cggattggaa tctgttatga aaaaagcaaa aacgatgctg ccggctatac 1163041 agaatatgaa ggtggatcgt ttttgggcgg gactccgtcc gggaacaaag gatggaaaac 1163101 cgtacatcgg cagacatcct gaggacagcc gtattttatt tgcggctggc catttcagaa 1163161 acgggatcct gcttgctccc gcaacgggcg ctttgatcag tgatctcatc atgaataaag 1163221 aggtcaacca agactggctg cacgcattcc gaattgatcg caaggaggcg gttcagatat 1163281 gatgctacag ctgaacggta aagacgtgaa gtggaaaaaa gacacaggta caattcaaga 1163341 cctgctggcg tcgtatcagc ttgaaaataa aatcgttatc gtggaaagaa ataaagaaat 1163401 aatcgggaaa gaacgctatc acgaggttga gctttgtgat cgtgatgtca ttgaaattgt 1163461 ccattttgta ggaggcggat gagcatgtta acaattggcg gaaaatcatt tcaatcaaga 1163521 ttgctgctgg gcacggggaa atacccatcg tttgacattc aaaaggaagc agtagctgtt 1163581 tctgagtctg atattttaac atttgctgta aggagaatga acatttttga agcatctcag 1163641 ccgaattttc tggaacagct tgatttatcc aaatatacgc ttttgccgaa tacagcgggc 1163701 gccagtactg ctgaagaagc ggttcggatt gcaaggctgg cgaaagcttc aggcctttgt 1163761 gacatgatta aagttgaagt catcggatgc agccgttcct tgctgcctga ccctgttgag 1163821 acattaaaag cgtctgaaca gcttcttgaa gaaggcttta ttgtgctccc gtacacgtcg 1163881 gatgacgttg tgctggcgag aaagctggaa gagctcggcg ttcatgccat catgccgggt 1163941 gcatctccga ttggatcagg acaaggaatc ttaaatcctt tgaatctgtc gtttattatt 1164001 gaacaggcga aagtaccggt catcgtggat gcgggaatcg gctcgcctaa agatgcggca 1164061 tacgcaatgg agcttggagc ggatggcgta ctgctcaata cggctgtatc tggcgctgac 1164121 gatcccgtga aaatggctcg tgccatgaag ctcgcagtgg aagcagggcg cctttcttat 1164181 gaggcgggcc gaatcccgct taagcaatac ggaacggcaa gcagtccggg agaaggtctt 1164241 cctgtatgac aggcaggtat tcaaggcagg agctgtttgc tccgatcggc ccatccggcc 1164301 agaaaaaatt gaaagaagcg cgcgccgtga ttatcggcgc cggcgcgctc ggaacagcca 1164361 gtgcagaaat gctggtgaga gcgggagtcg gctctgtgaa aattgccgac agagattatg 1164421 ttgaatggag caacctccag cgccagcagc tttatacaga agatgatgtc aaaaaagaaa 1164481 tgccgaaagc agccgctgcg gagcgccgtc tccgttcgat taacagcgat gttgatgtga 1164541 ccggccttgt catggatgtg acagcagaaa atatcttcga gctgattagg gatgcatcga 1164601 ttattgtgga tgcggctgat aattttgaaa cccgcctgat cgtaaatgat gctgcggtaa 1164661 aggaagggat tccttttctt tacggtgcct gtgtagggag ctacggtctt acctttaccg 1164721 tggtgccggg ttctactcct tgcctgcatt gcttgctcga tgcacttccg attggcggag 1164781 caacatgtga cacagctggc atcatcagtc cggctgtttt gcaggtagca gtctttcagg 1164841 taacagatgc actgaaactg ctgacgggag aggagtgcga gccggtgctg cgctcctttg 1164901 atttgtggaa aaacgagcgg tcagaagtga gagcggccag tctcaaacat gacgcatgcc 1164961 caagctgcgg cacaaaggat tttccgtttt tgtcttatga aaatcaaaca aaagcggctg 1165021 tattgtgcgg caggaacacg gtgcagatca gatcatctat tacgaaagaa gcggatcttg 1165081 aagcgcttgc cggtcagctg aggcaggccg ggcttgaagt agctgcgaac ccgtatttaa 1165141 tttcctgccg ctcggatgat atgaaaatgg tgctgttccg ggacggcaga gctttgatcc 1165201 atggaacaaa tgatattgcc cgggcaaaat ccatttatca taaatggatt gggtaataaa 1165261 aggagtgtag tgtaatgagt atatataaag cattgacaat cgccggatca gattcaggcg 1165321 gcggcgcagg gatacaggct gatattaaaa cctttcaaga gcttgatgta ttcggaatgt 1165381 ctgcgattac ggcggtaacc gctcaaaata cgcttggcgt tcacggggtg catccgctga 1165441 ctgtagagac gttgagacag caaattgacg ctgttgctga ggatttgaga ccggatgcag 1165501 ttaagacggg aatgctctgg aatgccgaca tgattgaaga agtggcaaga aaaattgacg 1165561 agtacggatt caatcgtgta attgttgatc cggttatgat cgcaaagggc ggggcatcct 1165621 tgctgcgtga tgagtcagtt gccaccttaa aggagttgct cattccaaga agctacgcga 1165681 ttacgccgaa tgtcccggaa gcagaaacgc tgacaggaat gacaatcagc tcgctggatg 1165741 accggaaaaa agcagcggag cagctcgtca agatgggtgc gcagcatgtc attatcaaag 1165801 gcgggcacca gcctgaggac aatcacatta ctgaccttct ttttgatggc agcatgttta 1165861 tgcaaatcac ccatccttat atcaatacga agcatacgca tggcacaggc tgcacctttg 1165921 ctgcggcttt aacggcccaa acggctaaag gagacagcat ccatcaggca tttgaggttg 1165981 cggccaactt tgtccgtgaa gcggtggaaa atacgctcgg catcggatcg ggacacgggc 1166041 cgacaaacca tttcgctttt aaacgaaaca gcttaaatac aagccgatga gatcaccagc 1166101 tgatggtgat ctcttttgcg tttgctacgg tatgcgcttt tcatctggac aaggttatga 1166161 tatgatagga attaagatca ggtactaata ctatgtcttt attaaatata ggaggcttta 1166221 tacatatgaa tttttcactt gaaggccgta acattgttgt gatgggggta gccaacaaac 1166281 gcagcatcgc ctggggcatt gcgcgttctt tacatgaagc gggtgcacgt ttgattttca 1166341 catacgctgg tgaacgcctg gagaaatccg ttcacgagct tgccggaaca ttagaccgca 1166401 acgattccat catcctccct tgcgatgtta caaacgacgc agaaatcgaa acttgcttcg 1166461 caagcattaa ggagcaggtc ggtgtaatcc acggtatcgc gcattgtatc gcgtttgcca 1166521 acaaagaaga gcttgtcggc gagtacttaa acacaaatcg tgacggcttc cttttggctc 1166581 ataacatcag ctcatattct ctgactgctg ttgtcaaagc ggcacgtccg atgatgactg 1166641 aaggcggaag cattgtcact ttgacgtacc ttggcggaga gcttgtgatg ccaaactaca 1166701 acgtcatggg tgtagcaaaa gcttctcttg atgcaagtgt gaaatattta gctgctgact 1166761 taggaaaaga aaatatccgc gtcaacagca tttctgccgg cccgatcaga acattatctg 1166821 ctaaaggcat cagcgatttc aactctatct taaaagacat cgaagagcgt gcaccgcttc 1166881 gccgcacgac aacacctgaa gaagtgggcg atacagctgc gttcttgttc agcgatatgt 1166941 cccgcgggat tacaggtgaa aatcttcacg ttgattctgg tttccatatc actgcccgct 1167001 aagcaggatc tatatcaagc aatcccgaat agggattgct tttttatttc ttctgatttt 1167061 cagctttctg tcatatagat agaatatgac acaatcggag ggatgaagat gtctaataag 1167121 aaaagaaacg cggataaaaa accgctcatg tatattgttc agccggatta tgcagaaact 1167181 acaaggtcat ccatgcagga gattgtcatc aaaagaaagg ccgacaaacc cgctccgcca 1167241 aaagctgagg aaaagccggc ttaccatgag aagcagcagg aggaagccgt ggcacaggat 1167301 gtcctgcaag aagaccaaaa gcctgcagcc gaaccagtga gtcagcaaac acaagaggcg 1167361 agagagccag agaacataaa aagccaagag gaacagaagg cagagccgca ggccgtagaa 1167421 gaaaccgttg aacacgagcc cccgaaagca gaaaaaaagg aagagcctgc acttgaggcc 1167481 cggaagcctg agaaagaacc ggaagctgtc catagtgctg ataaagcgga ggaaaaagca 1167541 ccgccggcac gaaaagtgaa aaaaccgatg agcaagatga cgatccacga aaaaattgat 1167601 tttttaacaa agctgcctca taacatgccg agagcgcttt gtttgattga agccaatgga 1167661 agaacgtaca ggggcgtgat tgtcggaaga agaaatgatt ccgtcctgct tcgaacaacc 1167721 ggaaacggag ccccaaccga actggcaatc gatgatatta cctctttgca cccgctcggt 1167781 ttttaacgaa aaagaaaaaa gctgcccggc tgatgttgcc ggacagcttt ttttacatag 1167841 agaaaagcct gcaggcctgc aagcttttcc agcttatgat taatgatgat gtgtacgatt 1167901 gattaatcga ggatttaagc agttgattgc gcagaagcag tctaagtcaa cttcaataca 1167961 gtagttcgtt ttttcgagtc ggaacacttc acacaccgta tctttatcgg tgaagtccaa 1168021 aatgtgtttg tgttcgtcaa atgcgattaa taatgacagt gttgcacagc ttccatgcac 1168081 tctttcgacc ctgaaaaata ctgtattaaa gcaagggccg ttatcgagtt cgccgacatt 1168141 tccgaaggcg actaatggcg ttgattttga tgtaaatatt gcaaaaggca ctgtgtcgcc 1168201 taacgaatgg cttacagata aaagcttaga gtggcagccg gtcgggcagt cttcttcaac 1168261 agcgttttgc agatcttcaa tattttctac agcttcacgc acgcagcttg atgttttctg 1168321 gctcatatta tccctcctgc cttataaatt tgagactggc gaaatgatgg agagtcagct 1168381 gcctcacgct ggaagcagct gaatgatttg cacctgtaat agagtttgga aggggattcc 1168441 tctttacaag tgtttatcca ttgtgatgat gctttttatc tttgtgaggc gatgttctgt 1168501 caactagctc tggtgacagg cactgaatcg cgcagaagca tccgagatcc acttcaatgc 1168561 agaaatctgt tttttctagc ccgaagaaat ccgggtcgca agggtggcaa acacttaagg 1168621 tatcgccttt gacatcgacc gggcgtaaaa tagacagtgt tgcacagcaa tcgcataatt 1168681 tttcgacgcg gaagaaaatg gattcaaagc attgcatatc atccacaaat ccccctacgt 1168741 ttccgaatgt ggagaacaat ccgccttttt tatcaaaaac gagaaacgga attgtgtctt 1168801 ttccagcaat cgtagggttt aaaaggttgg tatagcagcc agtcggacac tgttcttcaa 1168861 ctgcctcctg ctctgctaaa atcttttcca ctgcatcgca tacacagttc tcatgccggc 1168921 catgggtttt tccgcagctc attgatttca gctccttctt tatagggtat ttgactttag 1168981 tccttaacaa catatgtacc cgtgccccac ttggtgtggg tgaacgtcta tatattcatc 1169041 atatgcttgg aaaataagaa aaagcagagc gtttttagct ctgcttttag gtcctagagg 1169101 acaagagtga taactaggat ggctacgagt gtatttgttg ctgtagaaat aagggttgcg 1169161 atatcggcat ctactgttgt gacgtttacg ccgcgggaac attcgatgag aagtttttgg 1169221 cggtttactt gtttgttagc tgtaagctgt aacaaatctt gtgcgactaa ttcggcaatt 1169281 acgccgtctg caattgatgt cagagttgcc gttacgacag cggcattaag tgctgttaca 1169341 actgatgtta cggcttgaac gtctgtagat gtaacattga tgtcacaaga atctctaata 1169401 ataatcgttt catctgaaac ttgtttgttg agatttgctt gagctagatc ttggtcgatg 1169461 aaggcgttgt cgttgccaaa aaaaccattg ccattacagc aaacgtcgca atgacatttt 1169521 ctttcgtgtt tttctttatc tttctctttg tcatctaacg gatggtcaca gtcaggatca 1169581 agtgcaaccc aagaatatgg tctgctttcc atatctattc ctccttttct tttactgtta 1169641 ttaaatgagc gagcctctta ttttgactga gtcatatatc ctgatgaaga accctatttt 1169701 ttatgattgg ctaattgtta tcgtttttcc gtctttgtct gatctgttca atgagctgct 1169761 ctctgcggct taacggtttt gtgttctttt gctcttgtgc ggctgcttct tcttttttct 1169821 tcttttggtt ttctattagc gcttgtgatt tagcttgtaa gtcttttaca agatttaaga 1169881 gcatttcttt ttcttcgtct gatacttttt tcattttgtc ttttgtgacc ccatgtttag 1169941 aaaatatatt ttggaccagc attttcgtca ttggatcaac ttctggaagc tttgcaagct 1170001 cttctttgaa tttatcgtta tctgacattt gttttcacct cgtcttttaa gtttgtgaaa 1170061 agaaagggtt aaaggacgtc aagttcacta agaatgctgt ttaacacctg aagcaagatt 1170121 tgtacaaagg ttattatctc gtcggcagac aaagtaattt tgatgttgcg gctgttgata 1170181 attttaatga tggttctttt tttgatttgg gagctatcga gaataagaat ttcacttgcc 1170241 actgcgtcag ccaaatcctc gtcggcgatg acgagctgag tcgccacgat aatcatggtt 1170301 gtcacaaagg cttgtataga aagggcagct gttatatgtg acgtgtcaat tgtgatattt 1170361 tcgcaatcaa tcacttcgat ctgctgttcg aattcgcttg ataattgctc aaatattgca 1170421 gggtgcaggg attcgacttt ttcttcaaat gacataacct tcactccttt cttatccata 1170481 ctctatataa tgcaaatggg gtgcagagcg gaataataaa aataaccaat tttctgccgg 1170541 acaagataca attcatgaag aatagggttt tggcatatat gtgaagggat catgattggc 1170601 aaaggagtga acgagtggtt ataaatgggc tgacaattgt tcttctatcg cttgcggtct 1170661 ttcggctcgc ccgcctgctg gtgtttgaca cgattatggc gccgcttcgc agtctgtttc 1170721 atgaagagaa ggaagaaaag gatgcggacg ggaacattga aacctatatc gtgattaagg 1170781 gaaccggtgt cagggcgttt attggtgaat tgctgagctg ctattggtgc acaggcgtgt 1170841 ggtgtgccgg ctttttgatt ttatgccagg cggtgatccc gcaagcggcg cagtggctga 1170901 ttttactttt ggcgatcgcc ggccttgccg gcattataga aacgctcgta tcaaaatggc 1170961 tgcaagaata aggcgttacc accagcaact ttctgtcaga atacgcataa agtagcatat 1171021 atgacataag gaaaggaagg ggacaaaaat gaatcagcat cataaacctt cccaaaaatc 1171081 tccatataca gattcatcgt atcaatcaaa aaagataaaa aagaaaggct gcgggtgcgg 1171141 aaataaaaag aaaaagcctc aatagcctgg caaagaaacc ggagaactcc ggttttttgt 1171201 ttttttaacg aggcggtctc gctcagcata tatcataagc ggggggataa aagtgaatga 1171261 gtttgaaaaa tggatagaag gaagatatga accacatgaa caaaagcaaa aagagcatga 1171321 agacacgatg ggcagtatca gaaaagactt ggatgcattt gataaagccg gtctggaatt 1171381 tgaagatgag attgaagagc tggctgaaaa aacggaggcc ttacttaaaa aacatcaagc 1171441 tcaatatgat caatcgtaaa tccgcaaacg ccctatgcga atatccaagc cgatcccagc 1171501 agctcacata gtgtatagag agtaaaggag gtgcttatct atgggctttg gatacggatt 1171561 cggcggcggc tacggcggcg gctgttatgg cggttatgct ggcggttacg gcggcggcta 1171621 tggttcaaca tttgttttgt tggtcgtatt attcattctc ctcatcatcg taggtgcatc 1171681 tttcttttaa gatgtattga ggaagtacgg gttataaccc gtacttcctt gccttgtgtt 1171741 tatttttaaa aatgttggaa aagcacattg tattatgtgc attcatacaa taccgtatta 1171801 ctccgccaaa aggaggcgca ttatggataa tcaatttttt aagaacatcg aaaagaaaac 1171861 aggtgtgaag atgcaggatg taatgaatct tgccggatca ctccaaaacg ctaattttaa 1171921 agatgaaaat acagtgcgca gtgtgattaa ccgcgtagcg cagatggcaa acagacgcgt 1171981 gccaaaagaa ttagaagata aaattgtgga atctattaca agcggaaaag aaaagcttga 1172041 ttttggcacg atttctaaaa tgatggataa taaataagtg gatggcctgg ctgactcact 1172101 gcagcgggcc tttttttaca gtaaaaaccc ggcagtaatc tgccgggctg ttaatgatgc 1172161 aagggctgtc ttgctttctg tagcagggga tacaaaaatc ttgagcggtt ggctgttttg 1172221 ccgcgcctgt tagcagggca agacaaatat aaatgctgtt tcgcccgggt catggctaca 1172281 tataaaaggc gtctttcctc ctcaagagcg gcctcgtctc cttttcttgc cgtttctaat 1172341 gagaaatcgt gcggaatcga gccatctaca gtgcctaaca cgtagactgt tttgaattca 1172401 aggccttttg accggtgaat ggtcatcagc tgaacgccat gttcatccgt tctgtttttc 1172461 tcagcggccc tcatatggtc tacgtgggca agaaagtcag gaatcgtttt gaacttcttg 1172521 gcgacaacct tgatgtcgcg caggtcatca gagccttttt ccagcttgtt gccctcattg 1172581 ccccgctttt ttaaatactc ggagaagccc atttttcctt ctgcaaaggt gatggcttct 1172641 acgggtttca ttgtgcggag gcttgcaaaa aacggtacga ttttcttgat tttgtccagc 1172701 tggaatggct tcagatcagg caatttggcc agcgctttga tcatggtaca gtcctctgta 1172761 atcgagagcg ccttcagcgt attcaaagcg gactgtttta aaaacaaggc gggaagcaag 1172821 tgtttaatcg cctcggtgtc atcctcattt tggctggcgt acaagtaggc gagaatctgg 1172881 cggacgatcc gtctgctgta aaacgattgg acgccgcggt cagctgtata cggaattgac 1172941 gattgatgaa gcctttcata tatagcacgg cctccgctgt ttgtgcggta aagaaccgca 1173001 aagtcttctg gactggctcc attttgaatt ttttctttga tatcggaaac gaccattgtg 1173061 gcttcttcct cttcatcata aggataaaac agcacaggga cctgaatgtc atcgcgggcc 1173121 gcttcaagcg ttttggcata tctgtttttg ttctttttca caacgatatc agcactagag 1173181 acgatcgggt gcgtagacct gtagttcgca gttaaataga tcgtcttcgc tcccggataa 1173241 tccttttgaa aatcaagaat gaaagacgga ttgcttccgc gaaacgcgta gatggactgg 1173301 tcatcgtctc cgacacagca caggttttgc tccgggctgg cgagcatttg catgattttg 1173361 tattgaaccg gattaatgtc ctgaaactca tcaattaaga tatacgtaaa ccgagattga 1173421 tattgttcca gaaggtcagg ccgctcgata aacaattcat agcaggctga agccatgtca 1173481 tcaaaatcaa attggctgtg ttcttttttc tggcgttcat aatgttcata taaacgataa 1173541 acttgttttt cccactcatc ttttagaggg atgcgttcat ttgggacata agtgtttttc 1173601 caaaaaccga tctgctgcag ggcttggtca actggggatt ctttctcatc gatgccttct 1173661 tcatagagtg cttttttgat atattgttcc cgctgccact ccattttcag cagatgctca 1173721 ccgttccatt tagcagaatt agagtgatac aagatcttat aaaacagact gtggaatgtt 1173781 cctgtcacaa ttcttctgac ttttgccggc tgtaatccgt actggttcgc catacgctct 1173841 ttcatttcag cgacagcttt tgttgtaaag gtgacaagca gcatattttc aggcggtatg 1173901 cctaagtgtt cgatcatgtg ggcggcacgg gctgtcagta cccgtgtttt tccgctcccc 1173961 gcacctgcaa gcacgaggag cgggccctct gtttccgtga cagctttcag ctgatccgtg 1174021 tttaaaccga cagacggaaa aaggctcgta tcgggttcta ttgtttttgg cacaaatggt 1174081 gttcctggtt taatgcttct aggacggtgc cattctgtaa cagctgggga cgggtcagcg 1174141 gcgatcgctt ttcccttggg taaacgaatg acaccagatt cctgatcatc ttcttttttc 1174201 ccctctttag agggcttcgg ttcgcacgcc tcctcacatg ccggaaaatc gcctggctgg 1174261 cgatggataa actctggcgg atcggcgatg ttaagccgta acaaaacggg ctttccgcaa 1174321 tgagaacaaa ataaatgtcc ttttattccc tcttcaaaga ggaattgata atgttctctc 1174381 gaatatgtat gtaaatgtat gattctatca ttcagtcggg cgcatttcaa aaaggggtcc 1174441 tcccaatcaa aaggtgttca ttacagacaa tgactatcat atcaaaagaa atgtgtttca 1174501 aaaagtaagt ttaagggaaa agagacagca gaggggtggg tattgtatga tatatgcagg 1174561 tcaaattcag aaccagcaat acgctcaata tgctaataga acgattggac ataagcagga 1174621 ttatgccgga accgaaaaaa tcagctatgt cccgtttcag cgggtataca aagaactgga 1174681 aaagcagcag gagaatcaaa cggcagctga aagaaaagta aacgagatga aacgtaagcg 1174741 ctctctttat aagagattgc gagaaaaagg aatggggaca tatattaatc gatatgtata 1174801 aaaaaccgtt cataccagag aacggttttt ttatatgcag taaaaatccg gatctcaaaa 1174861 gatccggatg cgttcagtcc ttcatcattt gtaagtgcgg aatgccggca tcgaggaatt 1174921 ctttttcaga aagcacgcga tacccgtgtt tcttgtaaaa cggcacagcc tgtgtttgcg 1174981 cgtttaaaat gaaaccggaa gcgcctccgt ctgccgcggc tttttcgagc gctttcataa 1175041 tgatgccgcc gacaccggct gagcggtggc ttttcagtac gcaaatccgc tctaacttgc 1175101 cgtagccgtc cttcatgcgc catcttccgg caccgacagg cttttcaccg tcatacacga 1175161 cgatatgctc tgactcattt tcaagttcgt caatttcttc ttcagcaggc acgttttgtt 1175221 ctttgacaaa gacttcttct cttacataga atgcatcttt cagttgttct tcattttttg 1175281 cgataactgc tttcaaacat tattctcctc tgcctagcaa gaaggtttca tatactgtcc 1175341 acgatccgtt ttccaactgg tagagcaagt ggaaacggtc aacgatttct tcatgcgaca 1175401 cttcctgcat ttttaattgt cccagcacat ctgaatgctc atcgtcggaa agattttggc 1175461 cgaccgtcac atgcggaacg aaattatatt cctgttctcc tgccaacaca ccggtgtata 1175521 gcttttcatt gagtgttttt aactcttccg tcggttctgc tttgatgtaa atgacattat 1175581 tgacaggcgc aaatgagctg tattttgtca ttttgagaac gagtgggtgg gactcttttg 1175641 cgatgtttct taaatgtgat acgagctgat ccgctttctc ctccgcgcat tcaaaggatg 1175701 ctctcagcgt caaatgaggc gggattagag agtagcttgg gtcatagcgc tttctgtaag 1175761 agtttgcaag gtcttggagc ttttttgatg gaaataaaac gattccgtat ttcatattat 1175821 gtccctcctg gaaataaagt atgatagagt gttaaagcat ttttttcagc gccggggtga 1175881 tgagcggctg ccagtatgtc catttgtggt ctccgtcaaa tggctcgaaa tcataatcgg 1175941 aaagcttttt ctccagcagc tgtttcagct cccggttcgg ttctgtaaag tccagaatgt 1176001 tcccgtctgt cgtgtggacg tcagtttctt ttgttccgat ttggtgataa atagagaggt 1176061 gtttgatatc gtctgactgt tttacggctt ctagtacgtg tttgtcaaca tagggagact 1176121 gcatgatgat gttgccaaac atattcggat aatcaagcgc tgtcataagt gacacggttg 1176181 ctccgagcga atcaccgatc agcgttcggc cgtaaccgat ctgataggtt ggatactcat 1176241 catctgcaaa aggaacgagc tcatgggcga tgaaccgttt ataagccgaa aattttgaac 1176301 cctccggatg ataagtgttt ctgcgctctt ttacatcctt atagggaaca ccgataataa 1176361 tgctccggtc tatttcgcgt ttcgacagca attcctcaac ctgtctgccg attctcccca 1176421 gcctgaaata atcgtggccg tcctgcgcga taatgacatg gtatttataa agcggggagt 1176481 agttggacgg cagataaaca agcaaggtca tttcctcgtt aagctctttt gaaaagaatt 1176541 tcttttcttg cactgtgccg tttttcggtg ccataaaaac attcctccag gacatcacta 1176601 tactttcttg cattttcaat tattgtacca tgaattatta gaaatttctc tctttaaacg 1176661 gttcggcaca cgaagaaaaa agtgttgaaa taaactgtga attgcgctaa tataaaacaa 1176721 tcagaaaatt gaaatcgata tttcttatcg tgagaggtgg agggactggc ccttagaaac 1176781 ctcagcaacc ggcttgtttt gcatttgcaa agcgccaagg tgctaaatcc agcaagcgtt 1176841 ttttatgctt ggaagataag aagaagcgtt aaaccccttc ttcttatgaa gaaggggttt 1176901 ttattttgaa aagggaaggt gtcagctata tgtcacagca cgttgaaacg aaattagctc 1176961 aaattgggaa ccgtagcgat gaagtcacgg gaacagtgag tgctcctatc tatttatcaa 1177021 cagcataccg ccacagaggg atcggagaat ctaccggatt tgattatgtc cgcacaaaaa 1177081 atccgacacg ccagcttgtt gaggacgcga tcgctaactt agaaaacggc gcgagagggc 1177141 ttgcctttag ttcgggaatg gctgctatcc aaacgattat ggcgctgttt aaaagcggag 1177201 atgaactgat cgtttcatcg gacctatatg gcggcacgta ccgtttattt gaaaatgaat 1177261 ggaaaaaata cggattgact tttcattatg atgatttcag cgatgaggac tgtttacgct 1177321 ctaagattac gccgaataca aaagcggtgt ttgtggaaac gccgacaaac cccctcatgc 1177381 aggaggcgga cattgaacat attgcccgga ttacaaagga gcacggtctt ctgctgatcg 1177441 tagataatac attttataca ccggtcttgc agcggccgct tgagctggga gctgacattg 1177501 tcattcacag cgcaaccaag tatttaggcg ggcataacga tctgcttgct ggacttgtcg 1177561 tggtgaagga tgagcggctc ggagaggaaa tgtttcagca tcaaaatgca atcggcgccg 1177621 tcctgccgcc atttgattcg tggcttctga tgagaggaat gaagacgctg agcctcagaa 1177681 tgcgccagca tcaggcaaac gcgcaggagc ttgcggcgtt tttagaagag caggaagaaa 1177741 tttcggatgt gctgtatccc ggaaaaggcg gcatgctgtc cttccgtctg caaaaagaag 1177801 aatgggtcaa tccgttttta aaagcactga agaccatttg ttttgcagaa agcctcggcg 1177861 gggtggaaag ctttattaca taccctgcga cccagacgca catggatatt cctgaagaga 1177921 tccgcatcgc aaacggggtg tgcaatcggt tgctgcgctt ttctgtcggt attgaacatg 1177981 cggaagattt aaaagaggat ctaaaacagg cattatgtca ggtcaaagag ggagctgttt 1178041 catttgagta aacacaattg gacgctggaa acccagctcg tgcacaatcc atttaaaaca 1178101 gacggcggaa ccggggcagt cagtgtaccg attcagcacg cctcgacttt tcaccaatct 1178161 tcatttgaag agttcggggc atatgattac agccgctctg gcacgccgac aagaacagct 1178221 ctcgaagaaa caattgccgc actggaaggc ggaacaagag gatttgcttt cagttcaggc 1178281 atggctgcca tctcaacagc atttttactg ctgtcacagg gtgatcacgt tcttgtgaca 1178341 gaagatgtat acggcggaac cttccgtatg gtgacagagg tgctgacccg gtttggcatt 1178401 gagcatacgt ttgtcgacat gacggatcgt aatgaagtgg cgcggagcat caagccgaac 1178461 acaaaggtca tttatatgga gacgccatca aatccgacac ttgggattac ggatattaaa 1178521 gcagttgttc agcttgcaaa agaaaacggc tgcctgacct ttctggacaa tacattcatg 1178581 acgccggcac tgcagcgtcc gcttgatctc ggcgtggata ttgtacttca cagcgcgaca 1178641 aaattcttaa gcggacacag cgatgtgctc tcaggtttgg ctgctgtcaa agatgaagag 1178701 cttgggaagc agctgtataa gctacaaaac gcgttcggcg ccgtccttgg cgtgcaagat 1178761 tgctggcttg tcctgcgcgg attaaaaaca ttgcaggtcc gtttagagaa agcgagtcaa 1178821 acagctcagc ggcttgcgga atttttccag aagcacccgg cggtcaagcg cgtgtattat 1178881 ccgggactgg ctgatcatcc cggcgctgaa acccataaaa gccagtcaac gggagcgggc 1178941 gccgtgctat cttttgagct tgaaagcaaa gaggccgtta agaagttagt cgagaatgtg 1179001 tcactcccag tcttcgctgt cagccttggc gccgtggaat cgattttgtc ctatccggca 1179061 acgatgtctc atgcggcaat gcctaaggaa gagcgtgaaa aacgcggtat cactgatggc 1179121 ctgctccgtc tgagtgtcgg cgtcgaacat gcagacgatt tagaacacga tttcgaacaa 1179181 gcgctgaaag aaattgctcc agtttcggtt cgttaaaaaa gaagccgggg atagtccggc 1179241 ttcttttatt attgttcgtc atcaggattc agaatcgcga ggacttgatg atcctcccaa 1179301 acgccattaa tttttacatt ttttcgggcg atgccttctt tatgaaatcc cgctttttct 1179361 aaaacacgca tggacccgag attacggggc atcacaccgg cttcaatccg atgcagtttc 1179421 aattcgtgga acgcataatc aacaaccaat ctgactgcct ctgtcataat gccctttcca 1179481 ttatgggctt tgtctaaaaa atacccgatg aacgcagttt gcagcgcgcc acggatgatt 1179541 tgaaagagcg aaaccgtccc gattaatcta tcgtctgacg ctgtaaagat gccaaaatga 1179601 tattcttcat ctttctcaag tctttcctga tactcggtta ttcgttttct ttgcccctca 1179661 accgtatagt aatcgtctgc gcgtatcata gaaaactgtt cgaaaaaatc tcgattttcg 1179721 ctttgcagcc ccagattttc ttcggcatcc gttacttcta aaggtctaac ataaatggtt 1179781 tttcctttta acatatagtg atctctccgt tctcatgtca gcattcctct tacattattc 1179841 tcagggaaat gcaaatatcc tttttataag aaggaagaaa accaatttcc cataaaagtg 1179901 ccaacatagt tgccgattaa gtagccgagc gtaccgacaa gcatgatcgg ggcgacaagc 1179961 tcccgccatc ccttggcaat tgccatcgca gccgcagtcg tcggtccccc gacagtagcg 1180021 ttgacggcga gcagaatttc ttcaagccgc acacggaaca attttccggc agctaaggaa 1180081 accgctaaat tgctaatcgc aatgataaac acgaataata gaataagagg cgcattcgtg 1180141 acgattaagc ggagatctgc aggaatgccg atcaccacaa aaaacaaata aatcaaaaag 1180201 gttccaagct cctgagatcc attgagcctt tcaaaaaaac gcgggaaaag aaaaatgata 1180261 agaacagtta aagacgtaag aaccaggtac tgatcgccaa gcgtaccggt cagcagggga 1180321 tgagaaaaaa tgcttttaaa ataaccggaa accttcatac taaccgcaac aagcgcgaaa 1180381 gcggcaccgg cattaaaagc gatatccttt aaggaaatat ccttccgttt ccaatagctt 1180441 tcagcactgt ttccgctgtt tccatcggct tttaccttct cttcaaacgg catggcataa 1180501 tgccgctgaa accatttgag tgcaggaatg ctgattaaaa taaaaaacaa aagcgccatc 1180561 ataaaattat cagccacaac ggtagccgac acatattcac caggcgtctc aaattttgcc 1180621 gccatcgccg caaagttgac cccgccgccg atataagagg cgctgatcat cccaccgatt 1180681 ttatctaagt aaggaatatg ctgtttgagt agaaaaaaag ccaggatact gccaagcact 1180741 gttccaacgg agctaatcag aaaaataaac agcaaacgcc tgctttcctt aaaaatttgc 1180801 ctaacattga tctgaaacaa taaaagtggt atcgccagcg gtaccacata agaccacaca 1180861 gtgtcataca cgggcgactc aacaggaagc actcctacat ttgtaaacac catagcacct 1180921 gcaagggcga taatagcgcc cgacacagca gacgcccact taaagcgctg ctccagcccg 1180981 atgctcactg ccgcccacac cgcaataaac ccccataata cccatacatc atcagaagaa 1181041 atcaaagaat gcaaaacccc atcacctcta ttgttagaaa attaagacat attataatag 1181101 ccggggaacg gaacagcaag tccaaaaaaa gtttttctaa aaaagcagtt gacgaataga 1181161 aggtaaggtt atataataga acttgtcaga aagataacaa catacccagc aacacataca 1181221 tatcatgatt ccgtagctca gctgggagag cgctaccttg acagggtaga ggtcgctggt 1181281 tcgagcccag tcggaatcat agcttaaacc cttgcgcagc aagggttttt tactttgcgt 1181341 taataaagcc ggttcgtcaa attcgtgagt tgttggcgaa ctgttggcga aattcattga 1181401 ccgcagtcca aaaactacct ccaaacttac ttgattagtt caatagtaac aaacggaaga 1181461 tcggatttct gttaaatctt cattgagaat agccagtcca agaccgtcac ttcagccatg 1181521 catcttttaa atgaaatttt gtactgaaaa catcaattgt atttttaaat tctgctctag 1181581 aatcagcccc tttataataa tcttgataaa ttgcttgggg tgatactgat tcgtgatttg 1181641 tgctatggtt tgcaaggctt gtagcaaaag caggagcaac agtaacgagt aaagcaaggg 1181701 ataatgcaaa accagttaaa gctttttcaa tttcatttta agcacttctt tttttaaaat 1181761 acaactttat tattaaatgg aatacaaaaa catccaaggt gtttttttgt tagtaagttg 1181821 agttaggggg attggatggc acttagaata ttgtttctgc tgatgggatg ttgattctgg 1181881 atatatttcc aacacgatta caggccggac atgaaagcga accttgcttt gatcggggca 1181941 atcatttcat ttacggctgc ggtttacttt aaagatattg atgtattgag agaagaggga 1182001 aaacaaatga acggaatttc tgagcgttgg aacacgttta aattacaaaa atcccctgaa 1182061 ccactctaga tcaggggatt gctttcccaa cagcttatta agtagcggaa ggcatgatca 1182121 acgatttagt atcaatttat taattgcgaa tactagaaac ataccgtttt ccgccttcct 1182181 tagaagtaac atattctcga ggaacattaa gtctattggt agaatgataa cttacataaa 1182241 gtttcatatt tgctcggctc gttacgatag ccgtatgatc catccaacca tcagcatagc 1182301 gaagacctat tttattatgg taatcatagt gatatacatc tccaagcttt acatttgaat 1182361 atgtatcaga aacagtcttc atttttattc cgccagcttt taaaatgtat gatctaaagg 1182421 ctcctgcatt aacccaagca tctgtatagg gtttccattc tttaaagtac ggcattcttc 1182481 cagctcttaa tgcttgggaa acaaagttag tacaatcttt gtctttataa tatttatagt 1182541 ttttatttgg ttttaaggca tatttttctg catatttcat tgcagcgtaa ccactatatc 1182601 ctttaacaga tgttgcagtc acagttagtt gattagagtt agcagcattg aagttcatac 1182661 ttactggttt atcttcactt ttcacttctt ctttatcatc atttttcact tcttgcttat 1182721 atttttttaa aaattcatct aatttaacat ccgaagaata ttcttcatca ttttcatatt 1182781 gtagagttga agaagaatta tttaattgtg ttacatttag ttgcttagaa gaattactca 1182841 atggtattac atttagttga ttagaagaat ttttaacttg agagaaactt agattagaag 1182901 tatttgttga ttgagaactt tgtttattag aagttgtttt gggaatttca agtttaatat 1182961 tatcgcccag agatgttgtt actttttcaa caccaaaaac aaagtttcga gtaatataag 1183021 cttcaacaat tagcttattg tttttttcag aagtcttaac atcgtctata tcgtatgtaa 1183081 actcgtggaa tttttgtttg tccactttac ttaacgcaga atacagtaag actccttcgt 1183141 cggaatcagt caatttagac tctttaggat gcgctaaagg agtgttgtgt tcaaaatcat 1183201 atttttgttg ttctaacata tccttaactt tttcgtaacc aatctcgttg gtaattgaaa 1183261 cattttcttt agtctcttta ttagtagtgg ctgcaaaaac ttcatttgtt gacactaatg 1183321 gtgacaatga tagacataaa actagtgaag caagtaattc ttttttcata cgaaacctcc 1183381 aataaaatct aaatataagt aatatttatc atttacacca attgaaatat ggcataaaat 1183441 acatgtaata atataacata aaaataaata cataaaaagg tatcggagga aaaaatgaaa 1183501 aagaaaacta aaattatact ttctctcttg gcagcactta ttgttatatt gatagtactt 1183561 ccagttctat ctcctgttgt ctttacagct tcttcggaaa aaggagcaat cagacacgaa 1183621 atttataaaa gaggatatcc ctaccaaagc tactttgcag ttctccagaa aagagaagga 1183681 gacaatgaat ctgggaatct ttattatgta aattggctag attggaaaga tgaaacaggg 1183741 caaactcctc acttatgcta ttcgaaaaaa tcatcagatg gtgaatacga agtaagttgt 1183801 ggcacagggc cgtaaaaata aattttaaaa ttgaataagt ccaagacgga aagcctgcgg 1183861 acactgatcg ttttacagag aaatttgtgc ttcgatcggt gtccgttttt tttcgcaact 1183921 aaccagatgt ctatcgcgat tactagctat gaaaggagta attagacatg aaacagtcca 1183981 aaaagaaacc atcacagaag caacatgagc gcttagatcg tttctggcaa caaatgatga 1184041 acactaacat gcaaacactc agacgtggca aaggcggcgc ttataaacgc agaaagtaaa 1184101 aagggagttt gaggatgatg aaaaacggat tcgcttataa aaacggaaag cttgtgaata 1184161 tcttttgcgg caaagaagag ctctataacg agttgaaagc cttcttggtc aaaaccttca 1184221 gtatcaacgt gaaagaggta tcgaggccct caatatatcg cagaacaaaa agcaaacaac 1184281 tggaatgaca cttactctat ttaactatca ggagggaaag cactatgaca gatcaaatga 1184341 ttgcatggga gattgaggaa tggattcgtg attataaatt catgctgcgg gagatcaaaa 1184401 ggctcaaccg tgtattaaac aaagtggatt ttattagcac aaagctcact gcaacatacg 1184461 gggaggaagc gggcatgcca aggggatcag caggcgtcag tcaggcagaa ttgcggcaga 1184521 tggaccgaag agaaaggcgg cttcacaaat atgaatctat tgtgcattac ctggacaatg 1184581 caatggaaca cattgaagaa gaaaagcacc gaatcgttta cgattgcatg atggaaggca 1184641 tgagctacac tgctattgca aaccaccttg attgctcccg ggataccatc agaaagatca 1184701 aaacagccat aatcggcaac atcgtcaata aagtcaaaga agccaacttt ctgcaatatt 1184761 tgaattcgtt taaatcggcg gtgtaaaatg gggggcagga tcggcgcggc ggattattcc 1184821 tgcgtcacca ccaatttcat acaatgagta aaacctccca gtggtaagcg aggatcaact 1184881 caactgggag gtcttacata gtgaatcggt gataaaacag cagcagtatt gcgtacatgt 1184941 taatatcccc gacaaaatat gtttttttca acagattcgt tcgacaaatt ttgcaaattg 1185001 ttaatcgata acttttcatt cccgatatta aaaatgggag tgaattgtaa aatgaaaaaa 1185061 cagaaaaata ataaaaagaa gaatattgaa aagcgaaata ttgaaaagcg aaatattgaa 1185121 gagaagaata atgaggactt agaagaactg gaaaatgcga tttatactta tcacaaaaag 1185181 gagctacttg ctttctttct tgaaaaaact cgaattggtc atgataagga agaatacaaa 1185241 aggttccaat ctcttcttta taagttggat attgaatgtt tagaatttgc tatatcgaga 1185301 ttttctcata tagatattat ccatgatcat tcaaaatatg ttccagcctt tatcccttta 1185361 tttgcagcat atctcaccat gttctttaat ttttatgaaa aacattgggg agctttatct 1185421 tttgctgctg gtacaattgc tgctattgtt tggataattg cagtagaaag aaaacataga 1185481 aatcaagcaa tttctattat gaaaatattt gaacaagtca aagagagaaa agtgaaagac 1185541 agatctaaag actgaaagga gaaaatatga ataaggataa attaaggtat gcaatcttaa 1185601 aagaaatttt tgaaggtaat acccctttgt cagaaaacga tattggagtt actgaagatc 1185661 aatttgatga tgctgtgaac tttttaaaac gcgaagggta tatcattggg gtccattatt 1185721 cagatgatag acctcattta tacaaattag gacctgaact gacagagaaa ggtgaaaact 1185781 acttgaaaga gaatggaaca tggtctaagg cctataagac cattaaagag attaaagatt 1185841 ggattaaata ataagagcat cctgcggggt gctttttttg ttccctgtaa actgcttccg 1185901 gtaagtctca ggatagacaa ttggcggtta acggcttgag cacggtggtg gtttagaggg 1185961 aatatctttt ccaaaacaac acgaatcaga agggggcggc ggtgaatgta gatggccgaa 1186021 aagcacattc aggcgtataa ggattacgtc aaaggcatga aatacaagga ccttgccgag 1186081 aaatacgggg tgtcagtgaa caccattaaa tcgtggaagc agcggcatgg ttgggaaagg 1186141 aaaaagggtg cacccattga aaaaagtgtg cacacaaaaa aaggcgggca accgggcaac 1186201 aaaaatgcat tagggaacaa tggcggcgca ccacagaaga atcaaaatgc tgtgactcac 1186261 ggctttttct ctaaattctt gccagaagag acgcttgaaa tcatggaaga gattcaggag 1186321 cgttcgccag ctgatatgat atgggatcag atacagattc aatatgcggc cattcttcgg 1186381 gcgcaaaaga tcatgttcgt ttctgataag gaagaaatga tcaaagagct gaaaaagaaa 1186441 aggtccctca tatctgaggt cagcgaaatt gaagatgggc ttgtcattag ttttagtacg 1186501 tggtttcgct acagacttta cagtgaaaca aacacctaac acatttcaca ttgcttcaga 1186561 ttgccttcaa acttgataat ataacttcta aaccttccta taaaatgaag gttttttatt 1186621 tgatttcaat ttttaaatcc tttacataca gcgattgatt aactcgagca atcaatgtcg 1186681 cagttatatt tatttttcaa gaaaatgtta taatgaaaag ccataaaatg atgggagggg 1186741 gaatttcgat gcattacata acggcatgtt taaaaatcat cagtgataaa gaccttaatg 1186801 agataatgaa ggaattcaaa aaacttgagg aagaaacgaa caaagaagag ggttgtatta 1186861 cattccatgc ttatccgctt gagccatcag aacgtaaaat aatgctttgg gagatttggg 1186921 aaaacgaaga agctgtgaaa atccatttca caaaaaaaca cacaatagac gttcaaaaac 1186981 aagaattaac ggaagtagaa tggttaatga aaagcaatgt gaatgattga aaggctcttt 1187041 aaaaagagac attcaatgac ttagtatcag ccacttgtga ctaagtagta aattgttgtc 1187101 caactcttat tttttctatt taatattttt tgagacgaaa atgttttttt aagctgattt 1187161 taaaatgtat tcaaagtcag ctctgtttga tttaatggat tatattattt ggatagcttg 1187221 ttaccatcat aatggagata ctccttataa attggaggtt aaaataatga gtcattctca 1187281 agaaaaaatt gcactaatta caggagcaag cagtcaaggg gatattggta cggctatttg 1187341 tcgtaagtta gcctcacagg gtatacatat cttctttact cactggaatt ctgatacggc 1187401 ctggatagaa gaatttcaac aagaaatttt acgtatgggt gtccgctgtg aggcaatgaa 1187461 aattgattta tcagatgcac atgctgcatt cacaatacat gaaaaaattt cagataaatt 1187521 aggatatcct tccatcctta ttaataatgc agctcattcc gcaagtgata attatgtatc 1187581 gttagatgct aaatcacttg atgagcatta tgcggttaat atgagatcga attttcttct 1187641 ttgtgttgaa ttcgcccgtc ggtttaaaaa atctaattta atatcaggaa gaatcatcaa 1187701 tatgacatca gggcaggatt taggtccttt gcctggggag ttagcgtatg cagcaactaa 1187761 aggagctatt tctgcattta ctaggtcgtt atcacaagaa cttgcaccat tgggcatcac 1187821 tgttaacgcc gtaaacccag gtccaacaga ttctacatgg atgacagatg aaataagaaa 1187881 ttttctttca cctaaatttc caatggggcg tattggcaca ccagatgatg cagcacgaat 1187941 gattgccttt cttgcaagtg atgaggctga atggataact ggacaaatta ttcattcaga 1188001 aggtggattt attcggggct aagctaatga aacacggtat acaccaatgt atgatgtatt 1188061 cccaaaacta aatctaaact tgaagcgaaa ataaggtccc ttctcttttt agagggggac 1188121 cttattttat tcatgcatgt tttgcatcca gaaaatctgg cggataaaga ttaataaacc 1188181 gttacatata cttttccgaa tactgcagta cctttaaaca aagtaatcgt ggctttccct 1188241 tttgatttag ccgtcactaa accattttga tcgacttcag caactttttg gttatcagtc 1188301 caataacgag tagctgaatt atttttaaca gaataggttt ctccaacttt tagaggtaaa 1188361 ttatagtctt gaatcttgat aacatgtgta ggtgaaatag aaatgttctt tacttcagta 1188421 ggtgtggagt ttatttcatg agctgaagct accccgctga ccgacagagc taacgcagaa 1188481 atcgataaag cagaaacaac cgtttttttg aaattcattt tgaaacactc ctttaaagtt 1188541 ttttgtcttg cactataaca attcaataaa agtaattatt ttccttgtaa ataaatgtta 1188601 ataatatgtg aacgatcaat tgatttgagc taagaatatt gtgtgccctg cacagagttt 1188661 gtatttatga tggaaaattg ctgagagaga atggccatcc ttaaaatgtt aatagcacac 1188721 atttgatggg tattagtttg ttgagcgtgt ggaaattttg ttacctgcac tttatccccg 1188781 aagataccaa atcacttttc ttcatcatgt tcttactttc gtactcatac attagaaaat 1188841 cttcgttcta aataggtgaa gaattggagt atttttatga atttctgctg aatatacatt 1188901 acatagcaaa ctcaaagagt ataaaaatcg cttttttccg gaagcttcgg taaaaaacga 1188961 aacttttgtc tctatgattt tgttttataa tgtaaacggt ttcttatata gtatacttat 1189021 actatcaatt tgctcaagta gatactgaca ggaaggatag aaaaacagat ggaatacata 1189081 aatacaagac aaaaagagat tttgtatctg ttgttatctg aacctgatga ctatttagtt 1189141 gtgcaagatt tcgcagatag ggtacagtgt tctgaaaaaa caatccggaa tgatttgaaa 1189201 gtgatcgagg attatctcaa tgagcattct catgcacagc ttattcgaaa accagggttg 1189261 ggcgtttatt tacatataga agaacaggaa aggacctggc taagccaaca attacatact 1189321 gaacattttt cttctaggca gcggagcgat aaggaaagaa tgctgcacat tgcttatgac 1189381 ttattaatga atccgaagcc tgtttccgca aaagacattg ccgctcggca ttttgtcaat 1189441 cgatcttcca ttaaaaagga tttatacgca gtagaagagt ggctgaagcg ttttgatctc 1189501 acactggttt ctaggcagcg gcttggatta aaggttgaag ggaacgaaag aaataaaaga 1189561 aaggcattgg caagaatatc tgatttgatt cacaatacag cgtttaccag ccaatttatt 1189621 aaaagtaagt ttttacatta tgaagtagac tttgtgacga aagaaatcaa atcactacaa 1189681 aaaaagcatt ccctctattt cacagacgaa acgtttgaaa gtttgttgct gcatacattg 1189741 ttaatggtcc gccgcatcaa aatgaagcag ccgatttcat tgtccccaaa agaaatggcg 1189801 gcagtaaaaa agaagaaaga atatcaatgg acatttgctt gtttacagcg gcttgaaccg 1189861 gtttttgcaa ttcgcttccc tgaagaagaa gccgtgtact taacattaca tatattgggc 1189921 ggtaaggttc gttatccatt gcagacagaa gagaaccttg aaaatgctgt gcttcctaag 1189981 gttgtagggc atttaatcaa tcgtgtttca gagctgaaaa tgatggattt tcacaaggat 1190041 caggatttga tcaatggttt gaacattcat ctcaatactg tgctacaacg gctgagctac 1190101 gatctttctg tagcaaatcc tatgctcaat gacatcaaaa agatgtaccc ttatttgttc 1190161 cacctcatca ttgatgtttt ggaagacatc aatcaaactt ttgatcttca tattcctgag 1190221 gaagaggcag catatttgac attgcatttt caggcagcga tcgaacggat gcagggcagc 1190281 agcgagacac ataaaaaggc ggttatcgtc tgccacatgg ggattgggat gtcacaattg 1190341 ctgcggacaa aaattgaacg gaaatatcac caaatcgctg taatggcttg tattgcaaag 1190401 gccgatttaa aggattatat caaaaagcat gaggatattg atcttgtcat atccaccatt 1190461 gcgctggaga atataacggt tccccatatt gttgtgtctc cgcttttaga gcctggcgaa 1190521 gagaagaaat taagtgcgtt tatacgtcag ctgggcgaat cacaccgcca aaaacaaaaa 1190581 acgtttcaga tgctgaacaa tacgactcct tttttggttt ttttgcagca ggaggcggag 1190641 catcgctaca agttaatcga acagctggcg acagctttgt ttgagaaagg ctatgttgat 1190701 aaggactatg cggttcatgc ggtgatgagg gaaaaaatgt cggctacaaa tattgggtca 1190761 ggcattgcca ttcctcatgc aaacgctaaa tttattaaac aatcagcaat cgcgattgcc 1190821 acattaaagg agccgcttga atggggaaat gaaaaagttt cgctcgtttt tatgctggct 1190881 gtcaaacacg aggatcaaac tatgacaaag cagctgttta gcgagctttc atatcttagc 1190941 gagcagccgg ccttcgtcca gaagctgacg aaagaaacca atgtcatgac atttttatct 1191001 catttggatt attaaaagca gggattattc cttgcttttt ttgttcatgg cagggcttga 1191061 gaaataaatt tgcgagtgaa gacgcctatt ctccagcaat gatctaaata aaataagagt 1191121 ttaatagttg gagaagaaat gttacactct tttctgtata tggtaaagaa tgaaaaaaca 1191181 cgattcggtt ggtagtccgg atgcatgatt gagaatgtca gtaaccttcc cctcctcggg 1191241 atgtccatca ttctttaata tcttttatga ggagggaatc gttatgaaat taacgattta 1191301 ctacgatggt cagttttggg taggcgttgt tgaagttgtg gacaatggaa agctaagagc 1191361 ctttcgtcat ctttttggca aagagccgag ggattctgaa gtattagagt ttgttcataa 1191421 ccaacttttg aatatgatgg cccaagctga gcaggaagga gtgcgtttac aaggcaggcg 1191481 tcaaaaaaag atcaatccaa aaagattgca gcgccaggtt tcaaaagagt tgaaaaacgc 1191541 cggagtaact tctaaagctc aagaggcgat aaagctagag cttgaagcaa gaaagcaaaa 1191601 gaaaaaacaa ataatgaaag aacaacgaga acatgtaaaa gagcaaaggt atatgctcaa 1191661 aaagcaaaaa gcgaaaaaga agcacagagg taaataatcc aaacaaaagc aggcgcagtg 1191721 cctgcttttg taattaagga ctctactttg taacatatat ccaatgttta tactccgctg 1191781 atttatgatt caatataaac cctaacttct ccaaggtttt ttgtgagcct agattatcat 1191841 gttcgcatct tgcggtgatc cgggatactg tttctcggct taatgcccag tttattagtt 1191901 tttgggcggc ttccacacaa taacctttgc ggcgatgact tttatttgtt gcaaaaccga 1191961 tttcaatcat gccattttcg tctgggtcac ctaaaaatcc agttccccca acaatttcat 1192021 aattgtcctt ctttacaata atccatgaat caaatccttt tgttccattg tttttgacta 1192081 aaatctcgcg gaaataaggt atcgcttcaa aaaaatcaga atttggccat tcaccatttg 1192141 tttcatagcc taattctttg atagcctgat gatcttgttt agacgcggcg tcaagaaggg 1192201 gaatatcaat cgtttgtaat cgtaatcgat tcgtttcaag gagaaccata tatttaatcc 1192261 tcttttcttt ttactgggaa taatgataac atataacaat tttctctggt accttggcag 1192321 tagagaaaga tgaaaaaatt gagggggatt gaaagagtga caggtgagag tttgcccaga 1192381 ccaaaaacgg gtaggaaaat gctgatgtta atgtgtccct acccgttttt ctgttcctga 1192441 atgcagggtt tctgataaca tgttgtgcta ccttttcgca atcaaataaa gcgatatggc 1192501 tctttgggtt tgcacaggat tatgaatgat aatgacccat tggtttcttc gtcttggaaa 1192561 gcttgctacc gcatacaatg gagcagtatc gcgcggagtg aacccaccat ttatcacgtt 1192621 gatatctctt ccttcaagat gacaaactaa gtattcacct ggattgatga cctgttggtt 1192681 cgtccatgcg taagaataaa agccgtctcc aagatcttcg gtggaagatg gggggacaaa 1192741 gccatctaca gtcaatgtga tttctcttct tcgctgtctt tctgaaaagt ctggacttct 1192801 ttgagggtta tgagtatgtg aaaagtaagg aattaacgca gggccataaa agtaatgata 1192861 caaagcaacc actcctttat tttccattca tacaaattgt atgtgggagt tatttgttca 1192921 ttcctgtttt gttccatgta gactaataat gggctatagg cgtccaagga aatcaatttg 1192981 tccttccgtt gattcaatgc tagtaacctt gaaaatgcag gttaggatga tagaatttac 1193041 atattactgc aagaagttag acatacatca ttttgatagt gggtgaaaac aatggcgaaa 1193101 aaaatggcaa aaacaaatgc ggttcgtctg atagaacagc agaacatctc ttatgaggta 1193161 ttagggtata aaacagacgg ccagccggta gatggcatct ctgttgcgga aaaaatcggt 1193221 tattctttga aatatgtata taaaacgttg gttgcagcag caggaacaaa tcattattat 1193281 gtctttgttg tacccgttgc agaagagtta gatgtaaaaa aggcagcaaa ggtgacaggg 1193341 gaaaagaaaa tagaaatgat tgcaatgaag gagctgttag cggtaactgg ctatcttcgc 1193401 ggcggctgct cgccaattgg catgaaaaaa ttgttcccga cctatattga tgcatctgca 1193461 gaaacgcttg attttattat tgtcagtgca gggaaaatcg gtatgcagct aaagttggcg 1193521 ccacaagatt tagccagatc atgtgatgcc gcatttgcag aaattgtata gatgcagata 1193581 taggggaacg aaaaagctta gtcatatcga ttaagctttt tccgcatccc tttcaaatat 1193641 gatttcaaaa taagcagctg ccccataccc atctatactg ggagcgaaaa tctgaacgaa 1193701 tctccagcct cttttcgcat aatcatggat gatttgctgg tagtcttctt taggccttct 1193761 tctcatcgta ctcagctcaa ctcttacgaa ttcatattct ttcatcgttt gatccctcct 1193821 attaaggtat acgtaaaatg gagcgagaag ttccgaaaac ctaggttaag gtcggaaagt 1193881 atatttcact cactaaacaa atccatttat gcctgatgcc tgcatgcatc tgggaagagt 1193941 taaggggcta taaaaacgaa ttttaccggg tcagcagtcc aaatgaatct cttgcttatt 1194001 gcatttgact gagtatataa gtaaaaaaag agcggccaga acatataaga aggagatgat 1194061 cattaacgca ctcataacag ggtagtgttt agcggagtag atgaaaaaat caagctgtga 1194121 aatttgtttg gggctgctga cggcatcaat tccattaagc agttttgaga gtttagcagt 1194181 atagttccaa tcaaatcgat ctgaaacaag ctcgcttcct tgataccaat taacagcagc 1194241 taaaaacaga aataccataa tagaaaatcc aagctgaaca actaaaaata ttcccttcac 1194301 ttttgtatga cctccaaatc tatgaatatg ggaaaatcaa acaatatatt accaccgtat 1194361 gggttattct tgcaatttca cttccataca actcaaacgc aagtctattt ttttgtttgt 1194421 ttttggctta taatacctga tgatggaaaa agagtgcggg tttatagatt agagaaacaa 1194481 atgtatttct tagcattttt tatttgtgga gagagtatag aagcattcga ttagatctgc 1194541 tttttcacag aaacggtttt catctgtttg cctgagcttt acaattggct ggcaaaaaaa 1194601 caatgatttc tttcaatcaa aacatgcaac gatgcgacac attttatatc ttgatgactt 1194661 atttcattgc ctttaagtca tcctatcgag aaagcgatgg tattttatga acaaagaaac 1194721 cctaaaaaac atactcatga ttttttcaat atgcgcaaca ctccgagaaa ccgatggtat 1194781 gcgcatagct gatagctgga ttttgagtga gattatacga tttttgattt gcatggttgt 1194841 gttttttgcc atgacatttc tattagatgc tgtttttcca aacaaaaaag agtcacatta 1194901 atgtgtggct ctttttgcat catctgatca gaaacatcat aaatgaatcg atcatcatga 1194961 tgaagaacag caagcaaaaa taaataagcg agtagacaaa catatccttt gcccacttca 1195021 cgtcatcgtc tgttttgaat cctttgatgc tttttttgat ccatatgcct ccgagaacca 1195081 aggcggctaa gaaataaaat gggcttatat ggccggtgcc gagagagaaa ggaaataata 1195141 gcgtgaccgg caccaggacg gcaatatatt gcatcatttt tatttttgtt acatgattgc 1195201 ctttgactac tggcaagagc ggaacgccag cagcgcgata ttcctctttg cgtcttatcc 1195261 caatcgccca aaaatgcggc ggctgccaca gaaacataat cgtgtacaac agcactgctg 1195321 tcatactgaa gtcaccggtt acggcacaat accccatcaa tggcggcgca gctcctggga 1195381 agctcccgac aaatgtgctc cacacagacg ttcgtttcac ccataccgta tagatgatcg 1195441 cataaaaaat aaaggcggcc agtccgagaa aggccgttaa tggattgagg gaataaagca 1195501 tggcaagacc tgcgattcct aaaacagagc catatgttaa gatcatggct ggcggcattt 1195561 tccctgtgac cgaggccctg ctgcgagttc gtgccatttt tgcgtccata tgccgatcaa 1195621 aatagttgtt atagacagtg ccggaagcca tcacaaacgc ggttcccaac attgctgtta 1195681 ccattgtcat caaaaaagcc aagccggtta acgttttttc tgcgcttgca aacgcgatcc 1195741 aaaacccgcc gaaggctgct atcgagtttg atatgataat gcccggcttt gcaagtttga 1195801 taaaatcgta aatggttacc cggttcgaag cttttatgta ttttgtttca gatatggctg 1195861 cagaatctct tgtattctcc aaaaatagac gcctccccca aaactgcatg cttttgttat 1195921 cgtaacaaga gggggacaga atcacaatta tttcccatat ttgtcatgat attgtcattt 1195981 ttaaaacaaa aaaatgggga gctggactgc ccccattttg atatgtggcg actagtaacc 1196041 gtaacctccc ccatatcctc cgccataacc tccgccgtaa ccgtaccaag ggtagtaagg 1196101 cggtcgcggg cgcgggtagt aataaggcgg gcgcggataa aacgggtaga acggataata 1196161 cggtcttgga taataataag gcggataaaa tggcggtctc ggacgcggat aataataagg 1196221 ctgtctttca tcataagggg taatttgttc aaatgactgt tcattcaaag ggtaatccaa 1196281 gaggaaaacc tccctagctt tttttattcc ttttaccata ttcctgatgc ttaagttggg 1196341 tgtatgtaca ttcatgaaat tcggtttttt ttatgatgaa attccttaaa aaggattgac 1196401 atgaacttct aaatctcata gtattacaaa tgtgaaataa atgttactac aatgttacaa 1196461 aaacatttct aaatagatac agttccaact gatgaagagt aaatcgaaat ggctacgaaa 1196521 gaaggagttt ttgttgttgg caaaaagaat caaatggttt catgtattaa tagcagttgt 1196581 atgtgtggtg ggccttatcg gctttttcca taatcattca ttgaaaaaag aaacggtcat 1196641 gaataaagta agaactgatt ctcaatatgg gaatgttgag atcgcaacgc ttgtgaatga 1196701 cgggaaaact tttaattacg cggtaaacta tcctgttttc aaaaatgaaa aaatggattc 1196761 ggcattaaaa agattcgcag aaaaagaggt tcgtcaattt caaaaggaaa caaaggacgt 1196821 tgaccaagag catacgacaa aacgcaacga attaaatgtt gattataaaa ttgtccatta 1196881 tgccaaacag acagtggcga ttgtatttaa tgaatataaa tacatcggcg gggcacacgg 1196941 gcaaaccgtg aaaaaaacgt ttaactatga ttttagtaaa caagcgtttc tttccattga 1197001 tgatattttc aaagaggacg ctgactactt acataagctt tcgttaatcg cttatcacga 1197061 gctgaaaaag aataaggaca ttgccgcgga cgatgcactg ttaaaggaag ggacggctcc 1197121 gaaaaaagaa aatttcagcc gctttgccat caaggaggat tatatcgaac tttactttga 1197181 cacatatcag gttgcagcag gctatcttgg agagcaatcg attgccatta agaaaagtct 1197241 tttgaaagac attctgaaag aacaatatat tgataaagca aaaaataaaa ataaaatcaa 1197301 agaacaaaag ccgaagcatg aagtgatttc tttacccaaa gaggaaacag ttgatccaaa 1197361 tcaaaaagtc attgcgctta ctttcgacga cggcccgaat cctgcgacaa caaatcagat 1197421 tctagactcc ttgaagaaat ataagggtca tgccacgttt tttgttttgg ggagcagagt 1197481 tcaatattat ccggaaacgc taataagaat gctgaaagaa ggaaatgagg ttgggaacca 1197541 ttcatggagc catccgcttc tcacaaggct ttcagtgaaa gaagcgttaa agcagatcaa 1197601 tgatacgcaa gacatcattg aaaaaataag cggatatcgt ccgacgcttg taagaccccc 1197661 atacggcggc attaatgatg aactgcggag tcaaatgaaa atggatgttg cgttatggga 1197721 tgttgacccg gaagattgga aagaccgtaa caaaaaaaca attgttgacc gtgtcatgaa 1197781 tcaggcggga gatggaagaa ccattttgat tcacgatatt taccgcacct ctgctgatgc 1197841 ggccgatgaa attataaaaa agctcaccga tcaaggctat caattggtga cagtttctca 1197901 gcttgaagag gttaaaaaac aaagagaagc gaaataaatt agaaaaggct gtccgtacgg 1197961 acagcctttt ttctatttaa taagagcctg tggtggccca aacatttaag tttggtcctg 1198021 aatacttgcc gaaagcgtaa gaagtccttg gatctaaatc atataccatc ggtgtatagc 1198081 aagacttttg gccggccacc gcttttccat tgccgcctgc agaatcacaa ttatatcttt 1198141 ttccgtctgt gttccgggta atctccgcat ttgcttcata gccagacgtc aatgtattat 1198201 tcatcgtgat ttttgcccaa gccgttttac atgtactgct gaatttaagc tcgactactc 1198261 cgatgacttg attgctggca ttcactaagt ttgaggattt ttttgtagag ccgctggacg 1198321 cacaatcatt gtaataaggg ctttttccat cgtaggcatg ggtttccgcc ttggcgggtg 1198381 cacctttgac ggcaaaaaca aatactactg cgaataacac caatgaagcc ttcataaaca 1198441 gtcttttcaa tttatgacct ccttaatatg gcaaacaata aatcatatgg aggaacaatc 1198501 aaaacatgca tgcttttttg tgaacaataa aggcggccgg gaggatggag ttcttggccg 1198561 cctctggtat gaggttatgc ttttacatca atggtttgtc cgagagttgg atgttgaatc 1198621 atctttaagg tttgatcggc attttgctgg gcggtgtcca gccttttttt cgttaaagca 1198681 atatttacat tctgggcaag ggatgcttga tgcatcgcaa ccgataaagc aggaatatcc 1198741 atggttccac ctcctatgcc ttacctatcg gcgggtttgt atgattttac agtgaaaaat 1198801 ggcttaattt ctcttgttga cccttacgct gcggcatatc gtatgttttt gacaaggagg 1198861 gaatcaggat gaatctagta atggaaaaga cctttgagca atacgaaaag ctgttttcaa 1198921 tggaagaaca gaaaagagaa gatgtatttc ggtatacgat gatgaggccg tttgaaaaga 1198981 tgtggaccgc catccaagtt ccgctgaaag cgaaggagcc aaacggctat gatgtgatca 1199041 tggctgcgaa aatgctgggc tatttggatg tccgtgatgc tgaaagcggc cagaaagcac 1199101 tacaaatact gaaagaatca catgtttcag agacagctga atctgcactt cggcaatgca 1199161 tattttttgc tgagcgcgaa cagctgcggg tgaatgcaaa ggagatcaaa ttcggccttt 1199221 atatcgctga tccaaataag cttcagctgc aaaaaggcta ctgcgggttt ggcgggatac 1199281 cgggctttat tcatgtatgg attaatccga acagttataa cctgccaagg attccttcca 1199341 ttattgctca tgagtttcat cataatgtgc ggttttcgta tatagatttt catcatggct 1199401 ctgtaagtgt cggggattat cttgtgattg aaggattggc ggaatcattc gccagagagc 1199461 tgtttggtac ggaacgattg ggcccttggg taactcgttt tgatcatgaa gacttgcaat 1199521 attccattga tgtgattaat gaggtgctgg atgtgaaagg attttcggaa gtcagccgtt 1199581 atatgtttgg tgatccaatt gctaacgacc aaggctttaa gcctgcaggt ttatcggctt 1199641 ttgcgggtta tgcagttggc tatcatgccg ttcagtcatt tatgaatcaa catcatatca 1199701 cgataagcga ggccacacgt ttggatgcga agaccattat ttctcaatgc ggtctgtttt 1199761 ctacatgaaa aaagcgtcac atacagcggc gctttttgat tcccaaaacc agcagttcta 1199821 tggcggcaca ggcggcaatt ccgattgtat atgcttcgat atcgctccat aaaaaaccgt 1199881 accctagtac aagcccgcca agagaagtat ctctaatctg gtcgatccat tcggcatgat 1199941 agagctggct gaattcaatg acaaaacaga aagaaagact gataatgccc gttatcattg 1200001 tcttcagctt ccgaaataga aatccgcatc ccgtgaagat catggcggcc cacaacgagt 1200061 ctcccagata agtattgagg gtatcaggaa gaacactgga gaatgctctg gatccaagcc 1200121 ccagcccaat gatcagtatg gtgaaaactg catatatcca acgatttcgc ttcattgcga 1200181 attgataccc cgtctctgct tcatctccct gtattgtaag gaatatagct tttatttgtc 1200241 cactaaaaaa gcggctgaat agccgcgtag ggtgtttatt ttgcttttag gtttacatgg 1200301 tcggctgtct gatccgtgcc tattacaaaa tggagttcat agcggcctgt atcatataca 1200361 taatcgattt catcggtaaa cgggacggtt aacacccgat ttactggtcc taattgcttc 1200421 tgcagcactt ccggcgtaac tccgcctaaa ttcagctgcc gttccacacc ggttccaaag 1200481 tagcggattt ctgaaattgt catgtcttta tgataggaaa atccgtagcc cggctgtccc 1200541 atattccagt gatataaatc aaatcgattg tctcccccga ctggtctttc cggttcccca 1200601 aacgcagcgt ggacatcccc ttttgtgctt ttgttaatgg taaggccttg cgcctgctga 1200661 ggcatttccc ctttataggc ggtgttatag aggtttttga caagctcagc ggctgattga 1200721 ttcgtgtttt ctgagagtgt gtttgtttga gctgcggcct ttgccggtgc tgaaaaggac 1200781 gcagccccaa agccggtaaa acagcttgtt actgctgctg ccgcggttat agcagacatt 1200841 gtctttttca tgttaatccc tcctaattga tctaccattc cgtttccccg tgtttttgca 1200901 acgaaacatg tgagtgcgct ttgtatgttt tattgagttg ttgtaaggga actgaaatag 1200961 gtaattcggt atataaagca agaaagggga atggagatgg ctggcaagaa aacaatcaca 1201021 ataaacggcg ttgaaatgga agcgtccgag gaacagacgg tgctgcagct tttgaataac 1201081 agctcgattg aagtgccgca agtttgctat catccaagct tagggccgat tgagacatgt 1201141 gatacgtgca tcgtcagcat caatggtgag ctgaagaggt cgtgctccgc tgaattaaag 1201201 gatggggatg tcattgatac gctctcacct gacgtgaaaa aagcgcaggt catcgggatg 1201261 gacaagattt tatataatca tgagctttat tgtacagttt gcgattacaa caatggggga 1201321 tgcgaaatac ataatacggt gaaggaaatg aaaatcaatc accaaagcat tccgtttgat 1201381 cacaagccat accataagga tgaatcccat ccgttttatc ggtatgatcc agatcaatgt 1201441 atattgtgcg gacgctgtgt tgaggcatgc caagacgttc aggtaactga aacgctgacc 1201501 attgactggg agcggaaacg cccgcgcgtc atttgggata acgacgtgcc gatcaatgag 1201561 tcgtcatgtg tgtcatgcgg ccattgttca acggtctgtc cgtgcaacgc gatgatggaa 1201621 aaaggaatgg aaggggaagc cggatattta acaggcatca ataacgaaac gctgcgaccg 1201681 atgatcgaga tcacgaaagg cgtagagaca ggctacggct cgattctcgc gatttctgat 1201741 atggaatcgg ccatgcgtga tgaacgaatc aaaaaaacga aaaccgtctg cacgtattgc 1201801 ggcgtcggct gcagctttga tgtctggaca aagggcagag acattctgaa agtagagccg 1201861 caggaggaag cgcctgccaa cggcatttct acttgtgtga aaggcaagtt cggctgggat 1201921 ttcgttaaca gcgaagaacg cctgacaaag ccgctgatcc gtgaaggcga tcatttccgt 1201981 gaagcagagt gggaggaggc gttattgctg atcgccagca agttcactga attaaaagag 1202041 gcgtttggcc cggattctct cgcttttatt acatcttcta aatgtacaaa tgaagaatcc 1202101 tatcttatgc aaaagctggc cagaggggtc attggcacaa ataatgtgga caactgctct 1202161 cgctattgcc aatctcctgc gactgccggc ctgttccgga cagtcggcta tggcggtgat 1202221 tcaggatcaa ttacagatat cgcgcaagcg gaccttgttt tgattatcgg ttcgaacacg 1202281 tctgagtcgc atccagtctt atccactcgg attaaacggg ctcataagct gagagggcag 1202341 aaagtgatcg tcgcggatat cagaaagcac gaaatggcag agcgctcaga tttatttgtc 1202401 cagccgcgtg ccggatcgga tatcgtctgg ctgaatgcga tcgccaaata tttaatagaa 1202461 aacggcaagg ccgatgaacg atttttgaga gaaagagtga acggacggga tgaatatgta 1202521 aaaagcctcg cgccgtacac acttgaatat gctgaggaga aaaccgggat tgatcaagaa 1202581 acccttatcc aaatggcaga gatgatcggg caagctgaca gtgtgtgcgc attgtgggcg 1202641 atgggcgtga cacagcatat tggaggaagc gacacgagca cggcgatctc taatctgctg 1202701 cttgtgacag gaaactacgg aaaaccggga gcaggttctt acccattgcg cggccataac 1202761 aacgtgcagg gagcaagtga ctttgggagt atgcctgaca gactaccggg ctatgaaaaa 1202821 gtgacggacg aacaagtccg ccaaaaatac gagcgtgtgt ggggtgtgcc gctgccgaag 1202881 gagccgggta tgaccaacca cgaaatgatt gaaaaaatcc attccggaca gttgaaagcg 1202941 atgtatgtaa aaggtgaaga aatgggcctt gtcgactcca atatcaatca tgtacacgct 1203001 gcatatgaaa agcttgattt ctttgtggtg caggacattt tcctttcacg tacagcggag 1203061 tttgctgatg tggttcttcc tgcgagcccg agccttgaaa aagaaggaac gtttacaaac 1203121 acagaacgcc ggattcagcg tttgtatcag gtatttgaac cgctgggtga atcaaagccg 1203181 gattggcaga ttattatgga ggttgccaat aagcttggcg ccggctggct ctatgagcat 1203241 cctgcagaca ttatggagga agcagccaag ctgtcgccga tttatgccgg tgtcacctat 1203301 gaacgtcttg agggctataa ttccctgcaa tggcctgtaa acgctgatgg aaaggattcg 1203361 cctttactct ttacagagcg cttccctttc ccagacggca aggccattct ctaccctgtc 1203421 cagtggacag agcctaagga attcggtgag gaatatgata tccatgtcaa caatgggcgg 1203481 ctcttggagc acttccacga agggaacctg acttacaaat caaaagggat ttcggagaaa 1203541 acaccggaag tgttcttaga aatttctcct gagcttgcgg cagaacgagg gattcaggac 1203601 ggaaccctcg tcagactcac atcgcctttc ggaaatgtca aagtgaagtg cctgattact 1203661 gatcgagtca aagggaagga agtatatctg ccaatgaacg attcagggga agcggcgatc 1203721 aacctgttaa caggcagcca tgccgataag gataccgata cgcctgctta caaagaaaca 1203781 tcggccaaga tggaaatttt gaagcacgac ggaatcagcc cgctgcctaa gatcaaccac 1203841 cgcaacggca atccgcagcc gcaaatcggt gtgcaggttc ataagaaatg ggcgcggaag 1203901 gattatattt tccctggtga cgctgtgaaa agggggatgg gccataatgg ctaaagcgat 1203961 taaacgaatc caaaaaatcg aggtaacaga agaggatcag cgaaagcgtg atttgcggga 1204021 aattgaagat gctctaattg accacaaaga agcgattctc gaaacattgc atatgctggg 1204081 ccatatgaac gagcgcgggg tcctgccgtt gctccgcggc ctttttggtc aaggggataa 1204141 agttcttgat atcctggtga aaaaggcaga tacagaggaa acagccaata cgctgaaaaa 1204201 tctgcttctt ctgtttggaa cactcggcat gctggacgtg aagcagctgg agcctctcat 1204261 tttgaaagtg aatgcgggtg tggcaagcgc tgtagagcag aaaaacagtg aagaaaagac 1204321 aggttatttt gatattatcc gctcgctaaa agacccggaa atcaacaaat caattacact 1204381 gctcttttcc tttttaaaag gaatgggaca agatacaaag gagctggaac gcacgacgca 1204441 gcctccggaa caccaaaaac atcatcagga accccgagag aaaagaggaa tgaataagcg 1204501 agattgacct cccacccgag cggcttcagc cagctcgggt tttttgatga aaaggtctaa 1204561 tggactagta aaaaatattc aaatactagg aagaagtaag attgtgatga atgagataga 1204621 aataatcgtt actttcttac ctgttaagaa aagggaaaat ctgattataa tagaaatcga 1204681 ttactttaga tgggggaaca atcatgaaaa aagtcttatt actattattt gtcttgacga 1204741 tcgggttagc gctttctgcg tgcagccaat cgagcgatgc gtcagagaag gaaaaaccga 1204801 aagagaaaaa atcgcaagaa gagcttgaaa aggaacttga taaggaattg aaaaaaggcg 1204861 gtgagccgaa gaccaaaaaa gatgatcaaa tacataaaat aggagaaaca tttaaagcag 1204921 gacatacgaa ttttacagtg aataaagttg atagagtgca aaaaggtgaa tatatgaatg 1204981 ttggcggagc tgtaaatgag gagacaaaaa caataaaaga tgatgaggaa cggcttatta 1205041 tagaagttac gatggaaaat ataggggaag attcaataag ctacaatttt atcgggtttg 1205101 atttaagaga taagaatgat caatcagtgc ggcctgtttt ttctatagaa gagaagggca 1205161 gaatccttat gggaggaaca ctagtatcgg ggaaaaaggt tacaggtgta ctcagttatg 1205221 tcatccctaa aggagaacag aaacattaca cactggtata taatccgttt ttagctgata 1205281 caaatagcag taatacagaa gagagagtaa aggacgatat tgattacttg gtgaagttag 1205341 attagatgct aatttacagt tgcacgtttt tcatctgtgg aaaacgtgca ttttttatag 1205401 cgaaacttga cttgaaagga tgagtgataa aagtgcaaac caaatggctg gaacgggcac 1205461 agcggattcg ggcgatcgcc caagcggggc ttgctttttc caaggatgtg tacgacaggg 1205521 agaggtacga agagctaatg aagcttagcg cggaaatgat ggcggattac tcggagaagg 1205581 acattgaagt tatcactgat ttatggcaag gcgagaaggg ctatccaaca ccgaaagcgg 1205641 atgttcgcgg cgctgtattc agagagaatc agattttgct tgtccgggag aagcatgatg 1205701 agctgtggtc gctgccgggc ggattttgcg agattggttt atcgccggct gaaaacgttg 1205761 tcaaggaaat caaagaagag tcggggtacg atacagagcc gtctcgattg ctggccgtgc 1205821 tagacagcca taaacactct catccccctc agccttatca ctattataaa atcttcatcg 1205881 catgcagcat gacggacggg cagggggaaa cagggatcga gacgaatcat gccgcttttt 1205941 ttccggaaga cagactcccg ccgctttctc ctaaacgaaa cacaccctca cagcttagca 1206001 tgctgtttga ctttttgcgc catccggaca agaaaacgat atttgactaa aaaagaaaga 1206061 gcctgtgggc tctttctttt ttataatgta atgtgttttt cgttggcgag tttcagaagg 1206121 gtcaaaatag aatcggcttg tttatggccg agtttttgct ttaatttgtt ttcttcaact 1206181 aatcggctgc cataaatttt gacggaggct ttgtcgacga cagtatgcca gttttcctgt 1206241 ttttttccct caacaagcgg tttttcatgt ctctcagaaa aagagaacac aaagagtacg 1206301 aatgcaagtg aaagtaggat tccgacaact tgttttttgt aatcagtctg tgctgccacg 1206361 ttgttctctc cttcaccttt taccttctat ttaatcatag aaccaaatta ttttacataa 1206421 tgggaaagtc atttttggag ttagtgcatt tggttgaaaa cagagacgtt ttttgagcgg 1206481 agcggtgcaa ttgaatccat attggatttg cgtgcttatg cctaaggtca cgttgtgagc 1206541 caaaacagca gtgcagaata gaaaaaaatt gaaagattat ggtaagatga acgaaattcg 1206601 agggggaata tatgatgcct gcatcgaaca tcgtgatcgc ctgcctgctg ttatcaattt 1206661 aattatttgt ggtagtccct ctctttttcg aaagcgggag gtgaagtgga acattaattg 1206721 ctgaattctt tcaaggggag tgaccgtaca tgaatgtgtt aaaccgccgg caagccttgc 1206781 agcgagcgct gctcaatggg aaaaacaaac aggatgcgta tcatccgttt ccatggtatg 1206841 aatcgatgag aaaggatgcg cctgtttcct ttgatgaaga aaaccaagtg tggagcgttt 1206901 ttctttatga tgatgtcaaa aaagttgttg gggataaaga gttgttttcc agttgcatgc 1206961 cgcagcagac aagctctatt ggaaattcca tcattaacat ggacccgccg aagcatacaa 1207021 aaatccgttc agtcgtgaac aaagccttta ctccgcgcgt gatgaagcaa tgggaaccga 1207081 gaattcaaga aatcacagat gaactgattc aaaaatttca ggggcgcagt gagtttgacc 1207141 ttgttcacga tttttcatac ccgcttccgg ttattgtgat atctgagctg ctgggagtgc 1207201 cttcagcgca tatggaacag tttaaagcat ggtctgatct tctggtcagt acaccgaagg 1207261 ataaaagtga agaagctgaa aaagcctttt tggaagaacg agataagtgt gaggaagaac 1207321 tggccgcgtt ttttgccggc atcatagaag aaaagcgaaa caaaccggaa caggatatta 1207381 tttctatttt agtggaagcg gaagaaacag gcgagaagct gtccggtgaa gagctgattc 1207441 cgttttgcac gctgctgctg gtggccggaa atgaaaccac tacaaacctg atttcaaatg 1207501 cgatgtacag catattagaa acgccaggcg tttacgagga actgcgcagc catcctgaac 1207561 tgatgcctca ggcagtggag gaagccttgc gtttcagagc gccggccccg gttttgaggc 1207621 gcattgccaa gcgggatacg gagatcgggg ggcacctgat taaagaaggt gatatggttt 1207681 tggcgtttgt ggcatcggca aatcgtgatg aagcaaagtt tgacagaccg cacatgtttg 1207741 atatccgccg ccatcccaat ccgcatattg cgtttggcca cggcatccat ttttgccttg 1207801 gggccccgct tgcccgtctt gaagcaaata tcgcgttaac gtctttgatt tctgcttttc 1207861 ctcatatgga gtgcgtcagt atcactccga ttgaaaacag tgtgatatac ggattaaaga 1207921 gcttccgtgt gaaaatgtaa tagataagga gactggagat tcatgaaaaa gtaccatatt 1207981 tcgatgatca atatcccggc gtacggacat gtcaatccta cgcttgcttt agtagagaag 1208041 ctttgtgaga aagggcaccg tgtcacgtac gcgacgactg aggagtttgc gcccgctgtt 1208101 cagcaagccg gtggagaagc attgatctat catacatcct tgaatattga tcctaagcaa 1208161 atcagggaga tgatggaaaa gaatgacgcg cccctcagcc ttttgaaaga atcactcagc 1208221 attctgccgc agcttgagga gttatataag gatgatcagc ctgatctgat catctatgac 1208281 tttgttgcgc tggctggtaa attgtttgct gaaaagctta atgttccggt cattaagctc 1208341 tgttcgtcat atgcccaaaa tgaatccttt cagttaggaa atgaagacat gctgaaaaaa 1208401 ataagagaag cagaggctga atttaaagcc tacttggagc aagagaagtt gccggctgtt 1208461 tcatttgaac agttagctgt gccggaagca ttaaatattg tctttatgcc gaagtctttt 1208521 cagattcagc atgagacgtt cgatgaccgt ttctgttttg tcggcccctc tctcggagaa 1208581 cggaaggaaa aagaaagcct gttgattgac aaggatgatc gcccgcttat gctgatttct 1208641 ttgggtacgg cgtttaacgc atggccggaa ttttacaaga tgtgcatcaa ggcatttcgg 1208701 gattcttcat ggcaagtgat catgtcggtt gggaaaacga ttgatccaga aagcttggag 1208761 gatattcctg ctaactttac cattcgccaa agtgtgccgc agcttgaggt gttagagaaa 1208821 gctgatttgt tcatctctca tggcgggatg aacagtacga tggaagcgat gaacgcaggt 1208881 gtgccgcttg tcgtcattcc gcaaatgtat gagcaggagc tcactgcaaa tcgggttgat 1208941 gaattaggcc ttggcgttta tttgccgaaa gaggaagtga ctgtttccag cctgcaggaa 1209001 gcggttcagg ctgtatccag tgatcaagag ctgctcagcc gcgtcaagaa tatgcaaaag 1209061 gatgtaaaag aagctggcgg agcggagcgt gcggcagctg agattgaagc gtttatgaaa 1209121 aaatccgctg tcccgcagta aaaacataaa aaccgaaatc aatttgattt cggttttctg 1209181 tttaaatatt ttttttcatc ccgcatctcc ggcattctct aagaaatttt ccgcctttta 1209241 cagagctttt gaacagtgtg taatcacagt tgtcgcagcg cccgctgcgg gcatccggat 1209301 attcattgaa ttcgtaaaca atcgatgtat cgtagccttt tgtttcatat tcttcttttt 1209361 tggtttccat gtcgatcctc cgttacaaga cgtgtctgct gtttatctta cagcaagctt 1209421 ccggcgtatt caatggattt taggaggttg ggtttatctt gatttctccc ttggtttgcg 1209481 ccaaaatagc tttattaagc ttatatacat aaaaagccta tgcaaagagg agaggaaacg 1209541 ggtatgggaa aagggttact tggaaaacgc gtggcaatcg gtggctcacg aaaaacggaa 1209601 gaaattagta caatcattga aaaacagggc ggaatacctg tcatccggcc tctccaaggt 1209661 acagtttact tagcagagaa gcaggtggag ccggatttgc ggacgtttgc ggaagaaaaa 1209721 gctgactggg tcattttcac gacaggcatc gggttggaga ctcttgtcga tatggcagag 1209781 aaaattggac tgaaagatga gtttctgcag gccattcgcc aagcgaaagc ggcatgccgg 1209841 ggatacaaaa cgctgtctgc gctgaaaaag cttggaatca caccggaagc ttcggatgaa 1209901 gacgggacaa caagaggctt aatccgttcc ttggagcctc acgacttttc aggaaaaaca 1209961 gtcatggtgc agcttcatgg cgaaaaagcg ccggctctca tggcatttct tgaagaaaaa 1210021 ggcgcgtctg tcctgccgat tctgccttat cagcacatcc cgccggagga ggaaacggtg 1210081 gagcggttat gccgagagct gatgaacgat gaggtcgatg ccgtttgttt tacaacggcc 1210141 attcaggttc gttccctgtt tgattttgcc aaggggcgag gttatatcaa tgaagtgaag 1210201 aaggtattcg aagaacgcgc catcgcagct gctgtcggaa aagtgactgc tgaagcactg 1210261 cgggaagagg gcattacgag actgcttgcg ccagagattg agcggatggg tgcgatgatt 1210321 gttgagctgg ccaagtatta tgaagaaaag gaataacaag tacaaaaagc cgcttttccc 1210381 tcggaaagcg gcttttgtct gtcattcatt ttgcttcagc tgctgatgaa cggtgaataa 1210441 tgatgggtat gtcagcacgc ttaagattac acaagtcagc gcggctgagg ccatcgttgt 1210501 aaacacgatt aagagttgaa agcgtactgc ctgaatcggg tccgcgccgg ctagaatctg 1210561 gccagtcatc atgccgggaa gctggacaag acccagtgtt ttctggcttt cgagcgtcgg 1210621 gatcatactc attttcatcg ctgaggtaag aatgcgctgt atggattgct tcggtgtgcc 1210681 gccaagtgac aatattaatt gaatttcttc tttgcgaacg ccgacttctg agttaagccg 1210741 gtttagaaac aaacttgaga gcaccatcga atttccgatg accatcccgc tgatcggaat 1210801 gacatatcgt gccgtaagcg gaatgatatg aagagacagc agaattccct gcgtcacaat 1210861 ttctacgatt gctaacgcgg caaacaccct ccaaaacgaa ccgatagtat ttttctttcg 1210921 cttgatgaca ttttgcgccg ccaccgcgag cattaacagc accatcagca ggataaaaac 1210981 agggtggtct ccgcgaaaaa tcagcgacaa aacataaccg atgataagca gctgcaccgc 1211041 ggcccggatg gtggcgatga tcatgtcttt ttctacaccg gctttaaagg attttgataa 1211101 aaacaaggcg atcaaaacaa agatcatcgt taaagagaga gaaaggtaat ccattaccga 1211161 gtgcctccct tcaaaaattc tttcgctgct tcatgctgcg gagcggagaa aaatgtgtcg 1211221 gtttcagcga tttcaagcag ccggccatct gccataaacc aaatggtatc ggctattcgt 1211281 tttgcctgct ccatattatg agtgacccac atgactgtcc attttttctc ttgatgctga 1211341 cgtttgatca gttcttcaat ctcaagagca gagaccgggt ccaaggccga tgtgatttcg 1211401 tccaacaata gaatggagga aggatttgag agcgttctgg ccagtgacag tctttgccgc 1211461 tgcccgcccg ataagtctct ggcgcttctg tctaacaact ctggcggcag ccctgcaagc 1211521 gaagccagct tttcaggaga gtacagctgg gattgatgca gcctttgtac aagacttaaa 1211581 ttgtcacgca ctgtcccgtc gagcacggga gccgattgaa acgcgagggc tgccgttcgc 1211641 ctcagctcat tgacattcca ttctctgact tcctttccgt atatgttgac ttcgccgctg 1211701 tcaggcgttc tcattaaatt acacatagaa aggagggtgc ttttgcctga gccggaaggg 1211761 cctaaaacgg ctacgattgc accctgttga atgtctccgg tgacatcctg cagcacatca 1211821 taggtttgtc catcttgttt atagcttttt ctgactgatc tgaaggagat ggctggtatg 1211881 ttttgtgttt gatcgtttgc ttccattaca ataatcacct ttcaatataa gtaggctgac 1211941 attatattta actataacgt gaaacagatt ccttttggta gcacaaataa aggagaacag 1212001 gctttcaccc attctcctgc agatgctacg cagtcagatt tgactgtgct ttctttttcg 1212061 gttttctcgg ctgtgaagcg aaggtatgta acatcatccc cgctattata atgaacaaac 1212121 cggcaaatga taatagagat gggaaaacgc ctgacagcag aacaatttca ccaagcagcg 1212181 cgaaaatcac ttcaccggat tgagtggctt caacagctgc gagtttttgc ggattgtctc 1212241 ttaccatatc agtggcccag aaaaataaaa ccgtcgcaat gatgcctgag ctgacggcaa 1212301 cgataaagga ttgaacggtt tgacttgctg ttggaaggcc atctgaccac cagccgtaag 1212361 ctgctaatat aagccagaat ggaaggcttg ccaatgtcat tccaagcacg cgctgaaatg 1212421 tatcaagccg gcctccgtat tcttcgagca ttcttcggtt tcctaacgga taggcaaaag 1212481 ccgcaatgac aaccggcagc acactgaaaa gcagcatcct cccagaaagc gattctgcat 1212541 gctgaagctg aatcagagcc gctccaatca ggatgatcac agaagtgcca agtgaaacca 1212601 ggggaatctt ttggcgaatg agctgcggac cgcccggcat atcttgtttg acataaaaca 1212661 aaggagataa gagcaccccg gctacaattg taatttgcca ggttccagct atgagccacc 1212721 ccggaccgta tgcagccgca aatgtaatcg gtgcgtaaaa aagcacgaaa ccgacgaagc 1212781 tccatttgat ccaataaaac ggctttttcc tcatttctag taagagaggc gtgaatgtcc 1212841 ctctcatgat gacaatcaaa cataaaaatg gcaccataaa aataaagcgc agcgaagagc 1212901 tccaaagcca gctgcctcct gataactcca tcgctctgtt taatataaag gtaacggcga 1212961 aaaagagtga agccaatatt ccgataacga tagctttcat gatatccctc attctggcat 1213021 tattttttta tactatacta ttcggtatca tgcagatcaa tggaatcatg agaaaaacat 1213081 catgtttggc gaaccgctat atgtggaaga caaaaaaggg aggtgaaatt gatggaaaga 1213141 gagacacaga catacttctt tccggatgac ggcaggattc cgaatcaccc tgattttccg 1213201 ctcgtggtgt atcaaaacgc gcttaaggac accggactgg cagagcggat cgtcacccgg 1213261 catggctggt caaacagctg gtcagggagt gtttttccat accatcatta tcacagcaat 1213321 acgcatgaag tcctgattgc ccttaggaga gaggctgtga ttcagtttgg gggagaaaaa 1213381 ggggctgcca tccctttcaa atcaggcgac gcagtcgtga ttccagccgg agtcggacat 1213441 aaaaagctca gctcaagccc cgattttact gtccttggcg cctatcccgg tggcgttcag 1213501 tacgatatga agacggggaa gccgaatgag cgggaggaag cggtcaaaca gattaagcag 1213561 gcggcgttgc cggcgaatga tccgatcaca ggaaaaagag agcctctatt ggaaatatgg 1213621 gtaaagtgaa ggggagaaat tgctggattg tcaataacta gtgccgcaga aacgatatga 1213681 catgagctcc atataaatta atttcataat cgaagcaatt cacgttcaaa ttttgttcaa 1213741 aaagtgttat catatagaag gtaatcgaat tggagttttt tgtgtttgct attttcagag 1213801 agagtaaagg attttgactt attcaattgt ttatttttag ataaaaataa tactgaatat 1213861 ggcaagatga aaaactgggt agtaaacatt tatttttgta aatgattgtg catgaattca 1213921 caatccttat tcttatgcct taaaagcgtg agacagggag aggcactacc ctttccaaaa 1213981 aaatcagcaa actgcttata gtaaaggaga attggatatg ccagaaacaa tcgatcaaac 1214041 aaatgcgtct gtcagccaaa gccagcaaga tcttattgat cagctattaa agccagaagt 1214101 tcaagaatca ttgactgttt tagttgacca gcttccgaag ctgactgagt tagtgaatat 1214161 tttaacgaag tcttatgatt tcgctcagtc tgtagcgact gacgaagtgt taaagagcga 1214221 cacagtcggt gcgatcactg aaattctcga gcctgtaaaa gaaacagcga aagaagtagc 1214281 tgcgactgcg atcgaagcaa aagaccgcgc ggaagcaagc aacgaaacaa ttggactttt 1214341 cggccttctt cgcatgctga aagatcctca agctcaaaag ctgttccgtt ttgctaacag 1214401 ctaccttgaa gtcatgaacg aacgcgaaaa ccaaaaataa tctcagattc aaattgatat 1214461 aaaggacgga ggatatacga tgtcaaaaca tattgtcatt ctaggcgctg gttatggcgg 1214521 agttctttct gctctaacag ttcgcaaaca ttacacaaaa gaacaagcac gcgtgacagt 1214581 ggtaaacaaa tacccaactc accaaatcat tacggaatta caccgccttg ctgcaggcaa 1214641 cgtgtctgaa aaagcggttg caatgccatt agaaaaactt ttcaaaggca aagacattga 1214701 tcttaaaatt gcggaagtaa gctctttctc tgttgataaa aaagaagttg cgcttgctga 1214761 cggttctaca ttaacttacg atgcgcttgt tgtaggtctt ggttctgtaa cggcttactt 1214821 cggcatccca ggtcttgaag aaaacagcat ggtattgaaa tctgctgccg atgcgaacaa 1214881 agtcttccaa catgttgaag atcgtgtgcg cgagtactct aaaacgaaaa acgaagcaga 1214941 tgcaacaatc cttatcggcg gaggcggctt aacaggtgtt gagcttgttg gtgagcttgc 1215001 tgacatcatg ccgaaccttg cgaaaaaata cggcgtagac cataaagaaa tcaaattgaa 1215061 acttgttgaa gcaggtccga agatccttcc tgttcttccg gatgatctta tcgagcgtgc 1215121 gactgcaagc cttgaaaaac gcggcgttga gttcttaaca ggtcttcctg ttacaaatgt 1215181 agaaggaaac gtaatcgatc tgaaagacgg atctaaagtt gttgccaaca catttgtttg 1215241 gactggcggc gtacaaggta acccattagt cggtgaatca ggcctagaag tgaaccgcgg 1215301 acgcgcgact gtaaatgact tcctgcaatc tacatctcat gaagatgtat tcgttgctgg 1215361 agacagcgca gtttacttcg gtccagacgg ccgtccatac ccgccaactg cacaaatcgc 1215421 atggcaaatg ggtgagctga tcggttacaa cctattcgct tacctagaag gcaaaacgct 1215481 tgaaacattc aagccagtaa actctggtac acttgcaagc cttggacgca aagacgcggt 1215541 tgccatcatt ggtgctaatt ctacaccgct taaaggtctt cctgcttcct tgatgaaaga 1215601 agcaagtaat gtacgatatt tgacacatat taaaggactt ttcagcctgg cttactaatc 1215661 cttttaatga atctggcatt gccaaaagca ttcctttccg agtgctttct ggcaatgtct 1215721 ttttttatgt ttatgacagc gttaacattt cattttcaaa aaagagattg atcccaaagg 1215781 aatataaagg taaaataaaa acaaatcaaa atgttaacgt taacattttg aaatagaatg 1215841 aaagacggtg aggacatgga acccttcatg ggcaaaaact ttttattgaa aaatgaaacc 1215901 gctgtcagcc tctatcacaa ttatgcgaaa gacatgccaa ttattgatta ccactgccac 1215961 ttaagtccga aagaaatcta tgaaaataag acatttcaaa acatcacgga agcctggctg 1216021 tatggtgacc attataaatg gcgcatcatg agagccaatg gaattgagga gacatacatt 1216081 accggagatg cgcctgatga ggagaaattt atggcttggg cgaaaaccgt gccgatggcg 1216141 attggcaacc cgctctacaa ctggactcac ttagaattgc agcgtttttt tggcatttac 1216201 gagattttaa acgagaagtc cgggtcggct atatggaaac agacaaataa actgctcaaa 1216261 ggggaaggct tcggggcaag ggatttaatc gtgaaatcaa atgtaaaggt cgtgtgcacc 1216321 acagatgacc ctgttgattc tcttgaatac catttattgt taaaagaaga caaagacttt 1216381 cctgtcagtg tgctgcctgg atttcggccg gataaaggac ttgagatcaa tcgtgaaggc 1216441 tttcctgagt gggtgcaggc gcttgaagat gccgctgcca tatcgattac aacctatgat 1216501 gagtttttaa aggcgttgga aaaacgagtg cgattcttcc actcagccgg cggcagagtt 1216561 tctgatcacg cgatagatac aatggtattt gccgaaacaa caaaagaaga agctggacgg 1216621 attttttctg acagattaca aggaacagag gtttcttgtg aagatgagaa gaaatttaag 1216681 acatatacgc ttcagtttct ttgcggtttg tatgcggagc tcgattgggc gatgcagttt 1216741 catatcaacg ctttaagaaa cacgaataca aaaatgatga aaaggctcgg acctgataca 1216801 gggtatgatt caatgaacga tgaagaaatt gctaagcctt tatacaagct gctgaactca 1216861 gttgagatga agaaccagct gccgaaaacg attttatatt cactgaatcc aaatgataac 1216921 tatgtcatcg ccagcatgat caacagtttt caggacggta ttaccccggg aaaaatacaa 1216981 ttcggcacag cctggtggtt taacgatact aaagacggaa tgctcgacca aatgaaagcg 1217041 ttatcaaatg ttggcctttt cagccgtttt atcggcatgc tcaccgattc cagaagcttt 1217101 ctttcgtata cgcgccacga atatttcagg cggatcgtct gcaatttgat tggagaatgg 1217161 gtggaaaacg gcgaagtgcc gcgcgatatg gagcttctgg gaagcatcgt tcaggggatt 1217221 tgctatgaca atgcgaaaca ctactttcaa tttcaagaag agaaagcaaa cgtgtaacaa 1217281 agtgtccgct cagtatcgct gagcggatca ctatccgaaa attcttaaga cacagaggtg 1217341 gaacatgcga actgaactgg caaataaggt tgtgtcggtc gaaacggaaa aaaggctttc 1217401 attgaaagag aaaatgtcct atggctttgg tgattttggc aacggtttta tgtttgatct 1217461 cggccagatt tatttattga agtatttcac tgatgtagcg ggaatccccg ctgcgatggc 1217521 cggcggcatt tttttagtca gtaagctgtt tgcagcgata acagatccaa ttgtcggctc 1217581 atcaatcgat tatcgcaaaa acatcggcaa acgggggaaa ttcaggcctt atctattaat 1217641 cggcagcatc gtgcttgcgg tgcttactgt tcttattttt ctgtctccca atgtatcaac 1217701 gaccggaaaa ctgatatatg catatgcatc ctatatgatt tggggcatcg gctattcgtt 1217761 tgtgaatatt ccgtacggct cattaggggc agcgatgact caaaattctg aggaccggac 1217821 ctccatttcg acgttccgcc aaatcggatc acttggcgcc ttgtttatca caagtgtggc 1217881 cgtgatgccg ctgctcgtca agtttgataa tccgaaggtc ggctacccgg tggtcatggg 1217941 cttgttcgcc gcgctcggtg tgttttggtt ttatatttgc taccgcaact gcaaagagcg 1218001 cattatcata tcggaagcac ccaaagaaaa attaacactc tcatctgtcg tcaaaacatt 1218061 tattacaaat aaaccgctgt taacccttgt cctgatgacg attttttcaa tttccgcata 1218121 caacattaaa tccgccatgc tcgtctattt cgcacaatat aacttgggca atgttgaatt 1218181 aatggcttat atgaacttca tcattattgg ttcttccttt ttgggcgtcg tattccttcc 1218241 aaagctcgtc aagatgtttg gaaagaaacg aacggcaatg atcggctttg gcatcagtgt 1218301 ggccgcggat ctgatcaact ttatgcttcc atctaacgtt tatgtgttta caattctcgc 1218361 cagtatcgcc tttatcggaa tcagtatccc aaatggcatc acgtgggctc ttgtctccga 1218421 tattatcgac tatggcgaat ggaaatccgg tgaacggaag gaagcaacga catattcact 1218481 tttcaatttc tcaagaaagc ttgctcaatc tttgtctggc tttctctcgg ggatcggttt 1218541 ggggattatc ggctatgtgc cgaatgcagt ccagacagca caggcgctga ttggcatcaa 1218601 agcgctgctt cttctgtatc cggccattgc tttggcatta gcgatgttca ttatcggctt 1218661 tctttataaa ctcacagacc agcagcatgc tcagatcgtt caggatcttc atcaaaagag 1218721 ctgacaatat aatataaaga atatttaaaa taatttgtaa ataaaatgtg tttgtagggg 1218781 tttcgcttgg agagtgccca aaaaactgaa aaggaaggag gcacttgctt gaaaacgata 1218841 acaattgcag ctgaagaagc aaaggaactc gtttggcaaa agctggacgg tgccggtttg 1218901 aatgaacgag atgctgaaaa agtggcagat gttctcgtgc acgctgattt gcgcaatgta 1218961 cattcgcatg gcgtgctgca cacagaacac tatgtgaaca ggcttttagc gggagggatc 1219021 aatcctgggg cacagcctgt ttttaaagag acggggcctg tgaccggggt gcttgacgga 1219081 gacgatggtt tcggtcatgt gaattgcgac atggcgatgg accatgcaat tgacatggcg 1219141 aagaaaaaag gagtcggcat ggtcacggcc gtaaacagca gccattgcgg agcgctaagc 1219201 tattttgtgc aaaaagcggc tgacgaaaag ctgatcggaa tggcaatgac gcatacagac 1219261 agtatcgttg tcccatttgg ggggaggact cctattttag ggacaaatcc gattgcttac 1219321 ggagttccgg ctaagcataa aaaaccgttt atcctagata tggcgacatc caaagtggct 1219381 tttgggaaga ttctgcaggc ccgtgaagag ggcaaagaaa ttcctgaagg atggggagtc 1219441 gatgaaaacg gagaagcagt aactgatcct gacaaggtcg tctcactttc aacattcggg 1219501 ggcccgaaag gctatggact atcgattgta gtggatgtgt tttccggatt gctggcgggc 1219561 gcggcttttg gccctcatat tgccaaaatg tacaacggcc ttgatcaaaa aagaaagctg 1219621 gggcattacg tttgcgcgat caatccatcc ttttttactg actgggatac gtttttagag 1219681 cagatggatg ccatgattga tgaactgcag caatcaccgc cggctgttgg attcgaaaga 1219741 gtgtatgtgc ccggcgagat cgagcagctg catgaagaaa gaaataagaa aaacggaatt 1219801 tctatcgccc ggagcgtgta tgaattctta aaaagcaggt gagtaaaatg aaagcggttc 1219861 aagtgcgaaa agcgtatgat ctggtgacag cggaggtgaa gaagccagtt ctttcaaagg 1219921 atgatgaagt gctcgtgaaa gtcaagcgag tcggcatttg cggttcagac atgcacattt 1219981 atcatggaac gaatccgctc gctaccctcc cgagagtcat cggacacgag gtaacgggac 1220041 aagtggaggc agttggtgcg aatgtacaga gcctaaaacc cggtgatcat gtggtgattg 1220101 agccgatttc ttattgcgga tcgtgctatg cctgccgcaa agggcggccg aatgtttgcg 1220161 ccaagctttc tgtatttggc gtacatgagg acggaggcat gcgggaatat attgtgcttc 1220221 cggaaagaca gcttcacgcg gtctcaaagg acttgccttg ggaggaagca gtcatggccg 1220281 agccttatac gataggcgcc caggcagtgt ggagaggcca ggtggaaaaa ggtgataccg 1220341 tcctgatcca gggagcgggg cccatcggga tctgtgtgtt aaaaatggca aaactggcgg 1220401 gcgctgctgt catgatgact gacttgaaca acgagcggct ggcatttgcg aaagaaaacg 1220461 gcgccgatgc tgttgtaaat gtccaagcag aacatgttgc cgagcgggtc cttgaatgga 1220521 ctgggaatga aggagcaaac gtggtcattg atgctgtttg cctgccggag acttttgcac 1220581 tttcaattga ggctgtgtca ccggcgggac atgtggttgt gcttggattt gatgaaagag 1220641 cggctcagat ttctcagctg ccaattacaa aaaaagaagt cacgataacc ggatcccgat 1220701 tgcagaccaa tcagtttcca aaagtggtag agcttttgaa tggaggccgg ttaatgcata 1220761 acgggctggt gacccataca ttttcagttg atgacgttca tcatgcattt cagtttatta 1220821 aggagcatcc agatcaggtg cggaaagccg tcatcacgtt tgattaaatg actgaatccg 1220881 gaggtgcgag catgaatatg acattccgat ggtatggacg aggcaacgat acagtcacac 1220941 ttgaatacgt gaagcaaatt cccggtgtca aaggcatcgt ttgggctctc catcaaaagc 1221001 ccgtcggcga cgtgtgggaa aaagaagaaa tcagagccga aactgaatat attcaatcct 1221061 atggttttca tgctgaagtt gtagaaagcg tgaatgttca cgaagcgatt aaacttggga 1221121 acgaagaacg cggccggtat attgaaaact acaagcaaac gatccgcaac cttgccggat 1221181 ttggcgtgaa agtgatctgc tataatttta tgccggtttt tgattggaca cgcacggaca 1221241 tgttccggcc gctagaagat ggatcgaccg ctctgttttt tgaaaaggcc aaggtggaaa 1221301 gccttgatcc tcaagagctg attcggacgg tggaggaagc atccgacatg acactgccgg 1221361 ggtgggagcc cgaaaaattg gctcggatca aagagctttt tgctgcctac agaacggtcg 1221421 atgaagaaaa gctatgggac aatttatcat tctttttgca ggaaattctt cctgttgctg 1221481 aggcctatgg tgttcaaatg gccattcatc cggatgaccc gccgtggccg attttcggac 1221541 tgccgcgcat tatcacagga gaggcaagct ataagaaact gcgggcgata tcagattcac 1221601 cgtctaattg tatcaccctt tgtacaggtt caatgggagc caatcccgct aacgacatgg 1221661 tggagatcgc taaaacgtat gccggcatcg ctccattttc acatattcgc aatgtgaaaa 1221721 tttatgagaa tggcgatttt attgaaacat ctcatttaac aaaggatggt tcgatcaaca 1221781 ttcaaggcgt gatggaagaa ctgcataagc aggattacga aggatatgtc agaccggatc 1221841 atgggcgcca tctttggggc gagcaatgcc gcccgggata tggcttatac gatcgggcac 1221901 ttggcatcat gtatttgaac gggctgtggg acgcttatga agcaatggca aaaaaagagg 1221961 tgggcatatg atcccgctgc atgagaacct ggctggtaaa acggctgtca tcactggcgg 1222021 cagcggcgtg ctttgctctg cgatggcccg ggagctagcc cgtcatggca tgaaggtggc 1222081 gattttgaat cggacggctg aaaaaggcca agcggtcgtg aaggagataa cggcggctgg 1222141 cggcacagcg tgcgctgttg ctgcggatgt gctggacagg atgtcactgg agcgggcaaa 1222201 ggaagacatc cttggccaat ttggcgctgt tgatctgtta attaacgggg ctggcggcaa 1222261 tcatcctgac gcgataaccg atgtggagac atatgaagaa gcgggagaag gccaatcctt 1222321 ttttgatatg gatgagaggg gctttctaac tgtattctcc accaacttca ccggtgcgtt 1222381 tctggcctcg caagtgtttg gtaaagaact gctgaaggcg gattcacccg cgatcatcaa 1222441 cctttcttcc atgagtgctt attcacctat gacgaaggtt ccggcataca gtgctgcgaa 1222501 agcatccatc aataatttta cgatgtggat ggctgttcat tttgccgaaa ccgggctgcg 1222561 ggtcaatgcg attgccccag gcttctttct gacaaaacaa aatcatgatc tgctgatcaa 1222621 ccaagacgga acgttcacca gccgatctca caaaattatt gcgggaacac cgatgaagcg 1222681 cttcggaaaa ccggaggatt tgctcggtac gctcctttgg ctggcggatg aatcctattc 1222741 cggttttgtc actgggatca ccgttcctgt cgatggagga tttatggctt attcaggtgt 1222801 gtaacgaaag cggtgcaaca gaaactgaac caacataggg gtgaggttga gatgttttca 1222861 aaagataagc ttcccgttat cctttttttg ttcctggcag gggtgattaa ttacctggat 1222921 cgctcggcgc tttccattgc agctcctttt attcaggatg atctcacatt gtctgccaca 1222981 caaatgggct tgattttcag cagtttttcg ataggttatg ccatttttaa ttttcttggg 1223041 ggcgtggcat ccgaccgcta tggggcaaag ctgaccttgt ttgtcgcgat ggttgtttgg 1223101 tcgctgttta gcggagcagt cgccctcgct tttggctttg tcagcctgct gattatacgc 1223161 attctcttcg gaatgggaga aggcccgctt tcggcgacca tcaacaagat ggtgaacaac 1223221 tggttcccgc cgacccagcg ggcgtccgtt atcggtgtaa ccaacagcgg cacgcccctc 1223281 gggggagcca tttccggccc gatagtcggc atgatcgcag tggcgttcag ctggaaggta 1223341 tccttcgttc tcattatgat tattggattg atatgggcag tgctctggtt caagtttgtc 1223401 aaagaaaagc cgcaagagac gatcaaggaa gcaccggcaa taaaagcaga aacgtctccc 1223461 ggagaaaaaa ttccgctcac cttttacctg aagcaaaaaa cagtcctgtt cacggcgttc 1223521 gcttttttcg cttacaacta catcctcttc ttctttttga catggtttcc gagctatctt 1223581 gtcgacgagc ggggattaag tgttgaatcg atgagtgtca tcacggtcat accgtggatt 1223641 ttaggattta tcgggctggc tgcgggggga tttgtttctg actatgtgta caaaaaaacg 1223701 gcccgaaaag gtgtgctgtt ctcgcgcaag gttgtgcttg tcacgtgttt gttttcatca 1223761 gctgtcctga ttggttttgc cgggcttgtg gcaacgactg cgggggctgt cactcttgtc 1223821 gctctgtcag tgttctttct ttatttgacc ggtgctatct attgggctgt cattcaagat 1223881 gtggttgatc aaaacaatgt cggttctgtt ggcggcttca tgcatttcct cgccaacacg 1223941 gcaggaatta tcggcccggc tttaaccgga tttattgttg accaaacagg cacgttttct 1224001 ggagcatttt tgcttgccgg tgggctggct gtcttcgctt cacttgctgt gattcgtttt 1224061 gtccgtccaa tcattggtaa gccagcggga acagaagctg agaatcctgt gtcttattaa 1224121 tctggaaata tagtgggaga ggcggtatgt ttgatgatac aatatacagt aaataatcgc 1224181 agccggtatg ataaggaagg gaattagatg gtaaccataa aagatatcgc aaaactcgca 1224241 aacgtatccc acactactgt ttccagagca ctcaacaaca gcccttacat caaagaacat 1224301 acgaagaaaa aaatattaga gctagcagag cagctcaact atacaccaaa tgtaaatgcg 1224361 aaaagtctgg cgatgcaaaa gtcgcatacg atcgggctat tctttacaag cattacaaac 1224421 ggaacctcac acagcttctt tgcagacact atcaaaggcg tcaatcaagc cataagtgag 1224481 gattacaatc tgtatgtgcg cggcattgat gatctgaaaa actatgactc cgttacaccg 1224541 atgagatatg acggcatcat tttaatgagc caaagtgaca ttgataattc ttttatttac 1224601 catattcgcg aaaaaaacat tccgcttgtc gtgctgaatc gtgatattga tgatcgtacc 1224661 atcacgaata ttttgtccaa tgacaaggaa ggctctcaag aagctgtaga atacttcatt 1224721 cagtccggac atcaagacat cgccatcatc gaggggatcg aaggctttaa atcctcccag 1224781 cagcgaaagg aagggtactt atccgcactg attcaacatc atattccgat caagcatgaa 1224841 tacagtgtca aaggacagta cgatatggaa agcggctttc aagcgatgga gcggctgctg 1224901 gcactgccga atcctccaac cgctgttttt tgttcgaatg atgacatggc aatcggagcg 1224961 atgaatgcga tattcgcaaa gggcctgcgc gttcctgatg atatttcggt gatcgggttt 1225021 gatgatattg ggttttcaca gtacatcacg ccaaggcttt caacagtaaa gcgcccagtg 1225081 gagaaaataa gcgtgctcgg tgcgcaaaaa ctcttgtcgc tgatcagcga gcccgaaaca 1225141 aaagcagaaa aaatcttgga aaacacagaa tttatggtgc gtgattcagt cagacgattg 1225201 acgacgtgat gtcccgtttt tcagcgggca ttctttatac agaaaaatgt taacgtgtgc 1225261 ataaagtgag agggaggcaa taagggtgca gaagctgaat aaaaatgtgt acgatcacta 1225321 tactcagtat ccagaaaaaa ttctccaatt cggagaagga aactttcttc ggggatttat 1225381 cgattggcag attgatcaat tgaatcaaca cactgatttt aatgggagcg tggcagttgt 1225441 ccagccaaga ggctcagaaa aaatcaaacg attaaatgag caagatggat tatatacact 1225501 ttttttacaa ggaatgaaag acggagaagc ggtaaacgag catatgatta tcaactcaat 1225561 cagccgggga attgacctgt tttctgatta tgaagcatac aaagaattgg catcaagcga 1225621 aaggcttcgg tttattatct ccaacaccac tgaggctggg attgtatgtg atgaaaaaga 1225681 tcgtttagag gataggccgc aaaaaacatt ccctgggaaa ttaactgcat ttctttactt 1225741 tcgctatcag gcttttaaag gagatcagac aaaagggtgt gtcctgatcc catgtgaact 1225801 gatcgagaat aacggtgaaa agctgaggga aacggttctt cattatgcac atctgtggaa 1225861 gctggaggaa ggatttacac agtggattca tgaggccaat acattttgta atagtttagt 1225921 agaccggatt gttccgggtt ttcccgtcga cagcattgat gagatcacgg cagatcttgg 1225981 ctatcaggat gatttgatag ttgtgggaga gcaatattat ttgtgggtta tcgaggggcc 1226041 tgattggatt ggaaaagaac ttccctttgc ggctgcaggg ctgcatacaa agatcgtcag 1226101 cgacctcacc ccataccgga ctaaaaaagt aagaatttta aatggcgctc atacagcaat 1226161 gacgccagtg gctttattat acggcttgaa gactgttagg gatgcagtcg agcatccgga 1226221 agtggggcga tttataagag agctgattga tgacgaaatt cttcctgttt taaaaatgga 1226281 aggtctttct cagtatgctg acgatgtgct gaaccgtttt aaaaacccgt atattaagca 1226341 ttacctggaa agcattgcat tgaacgccat ttccaaattc aaaacgagaa acctgccgac 1226401 tcttaaggaa tatgctgaac aaaagggaca gcttcctgaa cgcttggtgt tttctttcag 1226461 cgctcttctg tatttttatc atgataacga gacattgcag gatgatccgg cagttcttca 1226521 atttttcaaa gaggtttggt gtcaggagga tggcgacatg cttcggattg catcaagagt 1226581 gttaggcgaa cagcggctgt ggggggcaga tctcaatgag ataccgaagc tgactgatag 1226641 agtcgctgtt tacttgaatc atattcatga gctgggcatg cagagggctc ttgaacaata 1226701 ctgcatacaa gggggagagg tacgttgaag tcgtttataa agattcataa gcaagataat 1226761 gtccttcttg ctctgcggga tattcaaaag ggagagaggc tgcatgctta cggcgtgtcg 1226821 attgaagtaa aggatgatat aaaaagaggc cataagattg cattgcagtc tatcaaagaa 1226881 aacgacagca tcgtcaagta cgggtttcca atcggtcatg catcacaaga tatctcgatc 1226941 ggagagcata ttcatgtcca taatacgaaa acaaacctgt ctgatatcca attatacagc 1227001 tatacaccga gatttgatga aaatccgtat tctaatgaga accggacgtt taaaggtttt 1227061 agaagagaaa acggagatgc gggtgtacgg aatgaattgt ggattgtccc aactgtcggc 1227121 tgtgtcaatg gaatagcaga aaaaatgctg cagcgttttg tcagagaaac aggggatatc 1227181 gctccatttg ataacgtact ggtgttaaag catcaatacg gatgctcgca gcttggcgac 1227241 gatcatgaaa atacgaagca gatcctgctg aatgccattc gccatccaaa tgccggcggc 1227301 gtcttggtgt tagggcttgg ctgtgaaaac aatgagctgg caagaatgaa ggaagcactg 1227361 caagatgtga acttgaagcg ggtgaagttt ctggaatccc agtcggtgac cgacgaaatg 1227421 gaggcaggcg ttgctttgct gaaggaaatt catgaagcgg ccaaaggaga taagagagaa 1227481 gacattccgc tgtctgaact gaagatcggg ctgaaatgcg gaggttcgga cggtttttcc 1227541 ggcataaccg caaacccgct gcttggacgt ttttcagatt atctcattgc acagggaggg 1227601 agtactgtgc tgacggaagt accggaaatg ttcggcgcag aaaccatcct gatgcagcgg 1227661 gctgccaatg aagaagtgtt tcataagata gtcgatttaa tcaatgattt caaacaatac 1227721 tttattaaac atgatcagcc ggtgtacgaa aatccttcac cgggcaacaa agcgggcggc 1227781 atttctacac ttgaggataa atcgctgggc tgtacgcaaa aagcggggat ttctcctgtc 1227841 acggatgtct tgaaatacgg tgaagtactc aagacaaaag ggctgactct tttgagcgca 1227901 ccgggcaatg atttgatcgc ctcctccgca ttggcggctg ccggctgcca aattgtcctc 1227961 tttacaacgg gaagaggcac gccgtttggc acctttgtcc cgacggtgaa agtagcgaca 1228021 aacaccgagc tgtatgaggc gaagccgcat tggattgatt ttaacgcagg ccttttagca 1228081 gaggatgatg ttcatgagga atatgtgctg cgtgagttta tccactatat gattgaggtg 1228141 gcaagcggcc agcttgtgaa ccatgaaaaa aatgatttca aagaactcgc catttttaaa 1228201 tcgggtgtga cgttataata agaaaaggct atccttcaag cggatagcct tcttcattaa 1228261 atcaatttta aaccgctgac taaaataatg gaagccataa taaattgcag tggacgcggg 1228321 gagaatcgag gcgaaagatg gctcccgatc agtacgccgg gaattgaacc gaggagcaga 1228381 ttagctgcca gcatgtaatc cacgcttccg aagcttgcgt tcaaaatgcc tgctgccgta 1228441 acaagaagaa aagcatgcgc gatatcggtt ccgacaatct gtgacgcttt catgttaaat 1228501 aagtaaatca tggcgattgc aaataatgag ccggacccga ttgatgttaa tccgacgata 1228561 aacccaaaca caacaccaat aagaattgtc agcgccctct tattttcaag cggcatcagc 1228621 tgccagcggt tggggcgaag ttttctatcc aaaaacaaac gaacgatgat tgaaatggca 1228681 accagcgtta acacatatcc tagagcgtgc ttaataattt cttcctgatg ctggtgaaag 1228741 gcggggaaca aatgcaatat gccaatggct agcgaagcac tcggaatacc gccgatggct 1228801 aagtatttta ccaatttaaa gttaatcgtt ttctgccgcc aatgggaggc aacgccaaac 1228861 agctttgtga tcgagttata tacaagatcc gtaccgaccg cgatggaagg attaattcca 1228921 agcacaatta aaaggggagt taataaggcc gctccaccca ctcccgtcaa tccgactaag 1228981 gctccgacaa acaaacccat caatatgatg cttacactca tgataaaggc ctcctgaaaa 1229041 cccgactaga attcacccga atcttattcg cgttggtcaa gtattaattg taagtgctcc 1229101 atcggctgct gaaaaacccg agctctatcc gctccctgat ggtatcattc aattgacaac 1229161 accttataca tcaggagaac acgtctttca ggtgcaacga gcacttgcgg ctctgtattt 1229221 ttaccctgat aaaggcgctg ttaacaacgg aattgacggc gtttacggac cgaaaacagc 1229281 tgacgcagtt gcccgttttc agtctgttaa cggtctaact gctgacggta tctacgggcc 1229341 tgcgacgaaa gagaagatcg cagcgcaatt aagctgatca aagaccataa aaatcccgga 1229401 gccgctccgg gatttatttt ttcttcttca acttttttat aattccagca ctgcgctccc 1229461 tcacccgaag cgagtacccg gaaagcccaa accttccgta atcaacaaac ttcacacgcc 1229521 tcaccaattt tttcactgta tcacctgaca ttatcctctg tttgtattta ttatatgtca 1229581 ccctttaaga aaaggaataa ggacaagagc tgttttccct tgtcctttta gtgtgatcat 1229641 gctttttttc gtttatactc gtcaatcagc cgttcgtttt ctttgaagat tcttgctgta 1229701 tgcggactga cttgatagct tgcgacactg gtggttgaac gttttttcag gattttaaac 1229761 ggcttcgccg ctctgggctc gcatctgttt tgaaacgcac gttccattat ccttcacctt 1229821 cctcctcaat tggcagcacc aaatcatata tgctcgttaa tgacgtaaat agcaaataat 1229881 caaattccgt gacaatgctg tcagacgtca gcttgatgac atagttctgt gtctcgatgg 1229941 taaaagggat gagaaccact tttccgtatt ggtcgtaata aacatccttt cgatcgagcc 1230001 gtgtttgtac atctgccgga tcatccatat gctcggttaa ccggtcttta tcagcctgtg 1230061 tcgaatagtg gcaaagagaa gccgttaagt tcattttatc agcataggtt ttcagcagct 1230121 tatcaatacc ttcagcataa gcatctatac ttccataata aacatggatc ggttcgtttt 1230181 tcaataggta ttggtatgtt ttcagccgat tgagatacat gtggagcatt tcgttgtttt 1230241 cttcaagaat ttctcttgtg tctgtttcaa gctcgctgcc ggccagtttt ttgacatatg 1230301 cacttaagaa gataaaagca tcaatcaaag caaaactgac tgcgacaatg agataccgtt 1230361 cccagtgggt aaatagggaa gtgggctcat atgtccagta taccatagcg cccagaacaa 1230421 acagcaaata ccaagttttc cgaatggcgg acattttttc tttgaccttc gcttcgaaac 1230481 gccacgtggc atacacgtat aaccccagtc cggccacgat gcaccagacc atgatctgaa 1230541 agaataaaac catattcgaa tccctcacat ctgaaatagg ttctgcttat tgtattcgag 1230601 agatccggat ggttttcctg ttccatcaaa aaaaccgctc ctttgacaga agcggtgtga 1230661 cattaaaata tcatatttaa aataaagtag gcgatggcac caagtgtcgc tgaaatcgga 1230721 agcgtgatga cccatgtaat gagcattcgc ttggccgtac cccagtttac gccttttacg 1230781 cggtgggacg caccgacgcc aagaattgat gaagaaatga cgtgggttgt actgaccggc 1230841 aaatgaataa acgtggcgcc gaaaataatg gctgctccgg ttaagtcagc ggaaacaccg 1230901 tttaccggac ggattttcat gatctttccg ccaacggttt tgatgatttt ccagccgccg 1230961 attgatgttc cgagacccat ggctgtcgcg caggcgaatt gcacccaggt aggaatatca 1231021 ttagcagaag tatgtaaatt cgctgtgatg agagccattg tgataattcc cattgctttt 1231081 tgcgcatcgt ttgttccgtg tgtatacgat tgcagggcag ctgttacaat ctgcactctg 1231141 cggaattgct tattcgtttt cgccaagttg ctgtctttga aaatcagctt aacgatgcta 1231201 taaagaataa aaccaaggac aaaggcaata attggtgata gaatcagtgc ttcaatgatt 1231261 ttaatgaagc ccttatagtt taacgctgca aatccggctg ccgcaatggc tgcaccggca 1231321 atagcgccga tgatggcatg ggatgagctg cttgggatac cgtagtacca tgtgataagg 1231381 ttccaggcaa ttgcagcgag tagcgcagcc aaaatgacaa cagagccatt ttccagcgta 1231441 taaggatcta cgatgtcttt cgtaatggtt ttggcaacac ctgtaaacgt cattgctccg 1231501 acaaagttca tcacagcagc caatataatg gcatggcgcg gttttaacgc ttttgttgat 1231561 accgaagtcg caattgcgtt tgccgtatca tgaaacccgt tgatgaaatc aaacgccaga 1231621 gcacaaatga ctattagtat cgttaatatt aatagaatat ccatttttac ccctcgttac 1231681 gcgtttttca taatgatggt ttcaagatta ttggcaacac tttgacaaga gtcggcgatt 1231741 tcttcaagcg tttcgtatat ttcacgatat tgaatgactt tgattggatc tgtttcattt 1231801 ccgaaaagat tctttaatga ttttctgtgc aagttgtcac aactgtgctc atactcttta 1231861 attttgattg cgtgaggctg aatatccttt aagcgatttt ctgccagcag ctcgatcgta 1231921 atcaaaatct ctttcgcaca ttctctgata tatccgctga atttatcaat atgctcgtct 1231981 gatgaagtaa ttgagaaaat ctccatcatg gcagagaaat gttcgattcc gtcaagcaca 1232041 tcatccaagc tgtttgtcag ctgaaggata tcttcgcgct caataggagt gatgaacgct 1232101 ttgttaagct ctttaatcat gacatgaaca tgattgtcac cttttgtttc atattccttt 1232161 aacgtatctg caaattcttt aagagtcgtt tggttagtga ccttaaaatt cacaaaatat 1232221 tctgcagttt cgtctatgtt ctttgcaatt tctgttaaaa ggagtgagaa cttatctttt 1232281 tttcttctta tcattaaaaa ccctccatag tttgaatgaa caatgcacac atcaaattat 1232341 tatatagcct tttgtcgaaa aaaaacaggt aaagtcgaaa aaaacgtatc ttgacttttt 1232401 tgataaatcg tgtctcctta ttttgaccta cttcgcttta aaaaaacgac ccaagtttgc 1232461 aaaaactttc tgcttaacgt aaaaagtata tcaaaagttg tgtttttcct gtcaactttt 1232521 atcttctgtt tcaccaaaaa acggttccct aaacaaggga accgttttat cagcttgctt 1232581 ttcgtttttt catcccgtaa taaacaggca gtccggcaag gccgatgagg atggataatc 1232641 cgcagctcat tgtatctgta atgagtgtgc tgcctaacac aaagaaggag cccgcgattg 1232701 ccagaattgg cataaatgga taaagcggaa cactgtaggc gcgcttttct ccctttgctc 1232761 gcttgcggag aataaacact gcaaaaaagg ccatcacata aaaaatgtag atcatgaaaa 1232821 tggagatttc tgagagctta tcagggttgc tgatcagcat cataatcaaa gccaaagcaa 1232881 tttgaaaaga aatcgcaatc catggtgtgc ggaacgacgg gtgtacatgt gacagttttt 1232941 cagcaaatgg aagctgtttg cgttccgcca ttgcaaatga aacacgcggg aaagaaagca 1233001 cctttccatt taagcaccca aagatgctga cgataatccc tacactgatc agctttccgc 1233061 caattgaacc gaacagcatg gttgcagcgg tgcttgtcgc attttcacca agcgtgacaa 1233121 tttcgttcgc tgacaggatg tgaagcaatg caaaattaat gaaaatatag atcgccgtta 1233181 caattaataa tccgcccgtc atagcgcgtg gcagcagctt ttcgggattt ttcatttctc 1233241 cgccgagagc ggcaaggaga atccatccgt cataagcaaa caacgtagct aaaatagccg 1233301 ccccgaagtt catatcagaa atgctttcgt ttactgctgt gaagatgtgc tgatcgcctt 1233361 tccaaaggcc aaagacgatg atgcaggcaa tcggaatcag ttttccgatc gttgtcagcg 1233421 tttggacaaa accgccgtat tttgtaccga taatattaat gacgcataaa aagagaactg 1233481 ctataattcc aatgactttt gatagtccag atccccagcc gaaaagattc gccattaaag 1233541 atccaaaata taaacccagc gcgccaataa tcgccgggcc gtaaatgata atctgcaccc 1233601 agccgcacaa aaatccccaa aactcgccgt acacttcttc aaggtacgta taaagcccgc 1233661 cggtttttgg aatctgcgtt ccgatttccg cgattgtcaa accgcccgcc agtgttaaaa 1233721 taccgcctaa cagccaggcg aaaagcgcca tttttgaatc acctgaataa gcaagcacag 1233781 cgccgggctt cataaaaaca ccagaaccga taatggttcc gatgacaaga gtaagggcaa 1233841 acaagaggcc tatctctttt ttcaaaccgt tgtcttcagt atgcatgtcc ttaacctcct 1233901 atgatgttga agcttcatgt tgaagaatct attttttcat attgtaaacc ctattttaga 1233961 aaagtgaaat aaaataaatt ttctgatttt cgaaatttgc tttgtgtaca gcagataaaa 1234021 ctgtagaaat acctgtttta atggtctata aacgaataaa attcataatt tttatttaca 1234081 aagttcgtgt tttatgtatt aggattttag ccggtacaga ggggagatga gaattcagaa 1234141 aatgaacgaa ccttcggtga agctgatatg ttgactttct catgcgaata aaatactttg 1234201 ttattagaac aataaatata caattatgat atgatatctc gaaatcgaga taaaataacc 1234261 tggagggaca gcatatgaaa gttaacggca ttcaccacgt atcggcatta acggccgacg 1234321 cacaaaaaaa cttggatttc tataagaaag tattaggatt aaagctcgtc aaaaaatccg 1234381 tcaatcagga tgaaccgaca atgtaccatc tgttctacgg agatgaagtg gcaaacccgg 1234441 gaactgagct gacgtttttc gagattcccc gcattgcacc gtttcatgcg ggaacaaaca 1234501 gtatttcttc tattggattg cgcgttccag gcacagaagc cctgcattac tggaaagaac 1234561 gttttgaaga gcagcaagta acgcacagcg gcatctccaa aagagccgga cgtgacatat 1234621 tggcatttca agatcatgag gggcagcgac ttgtgctgac tgctgatgag gaaggaaaag 1234681 gatatggcct gcctgttaaa cagagcggca ttccggaaga attttcgttt cgcgggttag 1234741 ggccggttga actgactgtg ccatatgctg aaccaacttt acacgtattg acgaatattc 1234801 ttggatttac agaaatcagc cgtgaaccag tcgaagggca aggaaccgcc gttattctgg 1234861 aatcaggaga aggcggtgct gcaacggaaa tccatttaat agaaagaaac gatcttccgc 1234921 gagagcgtca aggcaaaggg agtgttcacc acgtcgcatt tcgggtaaga gatgaagaag 1234981 aacttgccgg gtggcaccgg atcatcagcc gcgaaggctt tagcaattca ggcatagttg 1235041 agcgctacta tttcaaggcg ctgtatttca gagaaccgaa cggcattttg ttcgagttat 1235101 caacagacgg accgggcttt atggtagatg aaaatcttga tgagcttggc caaacgattg 1235161 ctcttccgcc atatctagag catcgaagag cagaaattga agcaaaattg aaaccgatcc 1235221 aataaattgt gattcttttg ccttccggcg ccgccggagg gcttttttta ttaccataat 1235281 taattttgac ctaaacagca tgccttatta gggaggaaat atcagatgct gattgggaga 1235341 aatggcttaa aaccctttgc aaatatgggt gattggtatg gaatggcctc ggcaaaaata 1235401 ttgtctttgt ttattaatag tttattcata tttgcttgtt acactatttc aaagttagac 1235461 aaaaaggagt gaaaaataag tggaaaagaa aaaacgcgag ctggatatcg tcctcctcct 1235521 cattttgctc gcatctgcat tcttaaatat ctataacatt tggaaggacg acacggtgaa 1235581 tccttattac accgcggcag ttacaagtat gatgcaaagc tttcataatt tcttttatgc 1235641 ttcgttcgat gctgccggct ttataacagt agataaaccg cctgttacat accaaatcca 1235701 aacgatcagc gcactgatat tcggtatgca cggctggagc gtcatcctgc ctcaggcact 1235761 tgctggtgta ggttctgtcc ttcttatgta cttgctgata aagccgacat ttggaaaaac 1235821 ggcggcgcgt attgcctcat ttgttatggc atgtacgccg atagctgtag ctgtagcacg 1235881 tacaaacaat gttgatgcat tactggtatt tttcttattg cttgctacat ggcttctctt 1235941 taaagcgatc agaaaaggaa agctgatctg gctgttagca gcatttttcg ttgttggagt 1236001 aggttttaat acaaaaatgc tgcaggctta catgatttta ccggctttct tattgttcta 1236061 tctgattgcg gcaaacgcca caatcaagaa aaaaatcgtt tcattggtaa gtgcgttagc 1236121 cgtattagca gccgtttcgt tatcgtggcc gctcattgtt gacaatatcc ctgcaagcaa 1236181 gcggccttat atcggaagca gccaaaccaa ctctgttttg gaattggctt tcggctataa 1236241 cggaatccag cggctgacag gccaaaattc aggcggcggc cagggtgcgc caaacaaaga 1236301 cgcttcaaaa gaaatgtctt cttctgataa cactcaagca ccgcctaatc agtcatcaag 1236361 caacagctca tcaagcgatg gtaaatcctc aaatggcaat atggcggcgc ctccatccaa 1236421 tggccaaatg ccaagcggcg gtcaaggagg ccctccaagc ggcggagatg gcggccaagg 1236481 cggacccggc ggagacggag ggaaaggcgg tacaggaacc ggttcgaaaa tgcaatcagg 1236541 ttcagggatg tttggaacgg gaacacctgg tccactgcgg cttttccaac aagagttatc 1236601 tgatcaaatc agctggcttc tgccatttgc gatatttgga atcgcaggct tactgatcgc 1236661 tggcgcaaga gaaagaagaa gattatctgt agagcagaag gaaacggtgt tctgggttgc 1236721 gtggcttgta ccgattgccg gattcttcag tgtcgcagaa tttttccatc attattatct 1236781 catcatgctg gcaccgccga ttgcggctct tgtcggtgcg gggtgggtcg ctcttgttca 1236841 tctgtaccgc aatcagacag gctggaaagc atggcttttg ccgggagcaa ttattgcgac 1236901 aactggattt gaattgttta ttctcagaaa ctacaacgat caaatcggtg ttggatggag 1236961 tatcggggta ggtgttatcg gcgtgttgtc agcgattgct ttgctgctgt ttaaacagcg 1237021 ccaaaaaccg ttcagttatt atgtttcact tgcagctctc ctcgcattgc tggtgatgcc 1237081 gatgtattgg gcaagtacac cgcttctgta cggaggcaac agctcactgc ctgaaacagg 1237141 ccctcaactc gcatcaatga gcggaaaagg catgggaatg tctgatgcga ctgtaaatga 1237201 aaaactgatc aaatatctag aggagaataa ctccggagct gaatacctat tcgccacaac 1237261 cgattcgaac acagcggcac catatatcat taaaacgaaa aaagctgtca tggctattgg 1237321 tggatacagc ggttctgacc cggcaatcac actgactcaa ttcaaaaaac ttgtaaaaga 1237381 aggaaaagtg aaatacttct tggcttctgg aatgggaaga ggcggaaaca atgacattgt 1237441 tgaatgggtt gagaaaaatg gaaaagaagt agcatcagaa aaatggcaat caagttctga 1237501 tcaaaaaaca gaaaatactg attcagctga tacatcaagc agcaaggctt caggtgaaaa 1237561 cggcaaaatg ggcggacctg gcggaatgaa tcagtcagca acattatacg aactacatgc 1237621 tgatgaatag gaggcaaaaa catgagcaga catattcaat attcaattgt tgtacctgtg 1237681 tataatgaag agcttgtcat tcatgaaacc tatcagcgct taaaagaggt catggatcaa 1237741 acgaaggaaa actacgagct gctttttgtc aacgatggca gcaaagaccg cagtattgag 1237801 attttaagag agcacagcct gatcgatccg agagtgaaaa ttattgattt ttcaaggaat 1237861 tttggacatc agatcgccat tacggcaggt atggattatg cacaggggaa tgcaatcgtc 1237921 gtcattgacg ccgatttgca ggaccctcct gaactgattt tagaaatgat tgaaaagtgg 1237981 aaggaaggct atgaagtcgt gtacgccgta cggactaaac gaaaagggga aacctttttc 1238041 aaaaaacaaa ccgcggctat gttttaccgg cttctcagcg gtatgacaga tattgatatc 1238101 ccgattgata cgggggattt tcgcctcatg gacagaaaag tctgtgatga aatgaagaga 1238161 ttaaaagaaa aaaatccatt tgtaagaggg ctagtcagct gggtgggttt caaacagaca 1238221 gcggtcgagt atgtacgtga tgaaaggctc gccggagaaa caaagtaccc gctcaagaaa 1238281 atgctgaagc tgtcaatgga cggcatcacg acattttcac ataaaccgct gaagctggca 1238341 agctatgcgg ggattttaat gtcaggtact ggatttctgt atatgtttat cgtgctgtat 1238401 ctgaagctat tcacagacag cacgattacc ggctggtcat cacttattgt gatccagctc 1238461 ctgttcagcg gcattgtcct tctgattttg ggcgtgattg gcgaatatat cggcagaatc 1238521 tacgatgaag ccaaagacag gccgctttac atcgtccaaa aatcgtatgg aattgaaaat 1238581 aaaagactct atagagacca gcatatgtca taacctcaaa ccccctgtcc gtaatggaca 1238641 gggggttttt atgctctgag cacgatctaa agcaaaagat gctgatagat atatggaaat 1238701 tgggtaaaga agagattgtg agcttgtact gcggttcagt catgctgaaa taaaaacagc 1238761 aaaacttaaa gatttcgtcc tcggctttgc tgcatgtcag ctgttatatt ggggggcttt 1238821 taagaaacgc atgattagag ccgtaccagt tatgtttaat agaatactcg tacccaatac 1238881 aattccccac gtcaacgtcg attcagagag aagaaagctc agcaaaagaa aagccaatcc 1238941 tgcgcagatc atacccagtc ccacggtttt catgttcatg cctcctagca aacgatgttt 1239001 ctagcatctg atgtgaatga tgtcaatctg tatgatatac ggatatctcg tcagaaagtt 1239061 tcatagaaca attaggtctt ttatctaata aaaagcctca gaccgctttt acggcctgag 1239121 gcattatgtc ttacgaagtt ttctcttctt tttgatccag tttaattttt ttcgtcattt 1239181 ctttgccgtt tcggagaatt ttcacttcaa cggtatcacc gatctttgcg tctttatata 1239241 agatattgcg caattcactg cctgtatcaa tttctttacc ttttaggccg atgataatat 1239301 cctccgcttt taatccggcc ttttcagcag gagagcctga agcgacctca cggatgtaaa 1239361 cgcctttatt cagctggctg ccgaacaggc cgagtgtgcc ttcttggtaa ttttgcggca 1239421 cttgctctag atcaagcatg ctgacaccga tatatggacg ttcaatttgt cctttagaca 1239481 gcaattcttc agcaatcggt tttacgtcat tgcttggaat ggcgaatccg ataccctcaa 1239541 catcatcctc actgattttc atactgttaa tgccgacaat tttgccgtct gtatttaaca 1239601 aaggaccgcc gctgttacct ggattaattg ctgcgtctgt ctgaatgacg ttaatgctcg 1239661 tttcgccggc tgatgtagac attgaaaccg ttctgtccac gccgcttaca attccttgtg 1239721 ttactgtgcg ggacaggtct tttccaagcg gatccccaat cgcaataacg gtctcgcctg 1239781 ttctaagatc agatgaatca ccgaagtttg ccacttttgt gacgtggtca tcactgattt 1239841 ggaggacggc taaatcagtt aacgagtcac tgcctaccag ctttgcagta acctcagtgc 1239901 cgtcatataa agataccttc agtgatgatg ccccttctac gacgtggtta tttgtaatga 1239961 tataagcctt gccattctct tttttgaaaa tgacacctga ccctgaaccg ctttctgtat 1240021 cttcgctgga atcagaagaa ctagagccga acaaagagct gtttgattgt gcctgaagat 1240081 ttgtaatacc gacaatcgct ggtgaaaggt cttctaccat atctgagatt ttagaagagt 1240141 cctcgctctt gaatgcagat gagctgcttg agcttttttt agattcagag gaggtgcttg 1240201 ttgctgtaac agattgcgtt tgctgctggc tggatgattg ttttgcagtg tcctgagaat 1240261 catggtcacc aagcggtgta aacgtgtaaa tgccaagagc aagactgccg ccgatcactc 1240321 cgccaagcaa cggtctgaac catccgaatc ctcgtttttt cttctcctga tcatgaatga 1240381 cattgcgggc cgagtaggag gcgctctgat cgttctcttt cgttaaaaag acctcattct 1240441 cattaccttt cgttctgttt tcatcacgat agttatccat catgttcact ccgtttctct 1240501 attttcacat gtctatttat attgataggt ttatgacttg agtttatcat aaacaaaaac 1240561 tgtgggataa aaatgaaaag attatgggaa attgtgaaaa agtgcggaaa acggtacact 1240621 tcatattgta tatgaaagga ctgagtcgat ggaacagatt ggattgattg gatatggcag 1240681 catggcggat atgatcgcta gacagctgtt gaaacatgaa caaataaaag agaatgagct 1240741 atttattgag acgagaacga agggggagcg gctgcgggca ctcatgtcag attatccaaa 1240801 cgtatcggct gatccgttgg agaattgggc aaatacgtgc caattgattt tgatatgcgt 1240861 cccgccactc catgtcatcg aaacaatgcg ccgtctgtac ccgtatgtga acagaaatac 1240921 tcacatcgta tccatagctg ccggtgtgcc gctgcgtctt ttggaggcag aaacagaagc 1240981 cggtatctca cgtgttattc ctgccattac gtccgaagca gaagccggca tctcacttgt 1241041 cgttcacagt gaagcactgg ctgcagagaa aaaagaacgt ctgaatgaat tgttatcggt 1241101 tttcagccgt gtacgggaaa tcaaagaatc gaatttagat gtggccagca atttaacgag 1241161 ctcggcaccg ggattcatag ctgcaatctt tgaagaactg gcactgtctg ccgtcagaaa 1241221 cagcagcctg tccaaagaag aagcctttga ttttctgatt cattcgctat acggaactgg 1241281 caagatgctg atcgaaaaaa atatgtcttt cgaggagacg ctggaacgtg ttgcaaccaa 1241341 aggcggaata acgggagagg gagctgaggt gatacacgcc tctgtgccgg acgtttttga 1241401 tgaggtattt gaaagaaccc tgagaaaata tgaactgctt acagaacagg ttggtaaaca 1241461 aacatgaatc cttgaaagag gattcttttt ttatcactga atgattgaga tttttcccag 1241521 ttatattgca tttttcctct ttttttaata taatttgtta gaatattcat aatttagtaa 1241581 aaaaggagga gcgttatgaa attgtacatg tcagtagata tggaaggtat ttcgggtctt 1241641 ccggacgata cctttgtgga ttccggcaag cggaattatg aacgcggacg gcttatcatg 1241701 actgaagaag caaactactg tattgctgaa gcgtttaaca gcgggtgtac cgaggtgctg 1241761 gtcaatgaca gtcattcgaa gatgaataat ctgatggttg aaaagcttca ccctgaagca 1241821 gacttgattt ctggtgacgt caaaccattt tcaatggtgg agggactgga tgatacgttt 1241881 agaggcgctt tgtttctcgg ttatcatgcg agagcctcga ctcctggtgt catgtcacac 1241941 agcatgattt tcggcgtccg tcatttttac ataaacgatc ggcctgtcgg tgagcttgga 1242001 ttaaatgcat acgttgccgg ttattatgat gtcccggtat taatggtagc cggggatgac 1242061 cgggcggcga aggaagcaga agagcttatc ccgaacgtga cgacagccgc agtcaaacaa 1242121 accatttcaa gatccgcagt gaagtgcttg tcgcctgcga aagccggacg gctgttgaca 1242181 gaaaaaaccg catttgccct gcaaaacaag gacaaagtca agccgctcac accgcctgac 1242241 aggccagttc tgagcattga attcgccaat tatggccaag cagaatgggc gaatctgatg 1242301 ccgggaacgg aaatcaagac gggaactaca accgttcaat ttcaggcgaa ggacatgctt 1242361 gaagcctatc aggcgatgct tgtcatgact gagcttgcga tgcggacatc attctgctaa 1242421 aggggtgttt taggctttgg cgcgatacat gataaagcgt ttttgggcaa tggcagctac 1242481 gattttggtg attaccaccc tgacttttgt tctcatgaag gtcattcccg gatctccttt 1242541 taacgaggag agaggcacaa atgaagccgt tcaaaaaaat ctcgaagcct actatcactt 1242601 agacgatcct ctcattttcc aatacatttt ctacttaaaa tccatcatta cattcgattt 1242661 cggaccttca attaaaaaac cgtcggacag cgtaaatgat atgctggaac gcggatttcc 1242721 cgtttccttt gagcttggga tgacagcgat tgtcattgct gtgatttctg ggctggtgct 1242781 gggcgtaatc gctgcactcc gccgcaatgg ctttttggac tacgccgcga tgagtcttgc 1242841 agtactcggc atctccatcc cgaattttat tctggcaaca ttgctcattc agcaatttgc 1242901 tgtcaatctc aaactatttc ccgctgcgac atggacgagc ccgattcata tggtgcttcc 1242961 gaccgcagcg cttgctgtag ggccaatggc gatcattgcc aggctgacac ggtcgagcat 1243021 ggtcgaagtt ctgacacagg attatatccg cacagcaaaa gcaaaagggc tttctccgtt 1243081 caaaattatc gtaaaacacg cactcagaaa tgcactcatg cccgtcatta ccgtcctggg 1243141 cacactcgtc gccagcatct taacaggaag ctttgtcatt gaaaaaatct ttgccattcc 1243201 gggaatggga aaatattttg ttgaaagcat taatcagcgg gactaccccg tgattatggg 1243261 aacgaccgtt ttttacagcg tcattctgat tatcatgctg tttttggtcg atttggccta 1243321 cggtctctta gacccgcgca ttaaactgca taagaaaggg tgaagcgtgt gaatctccct 1243381 gtacaaacgg atgaacgcca gccagaacag cacaatcagg tgcctgatga gtggtttgtc 1243441 ttgaatcagg aaaaaaatcg ggaagccgat tcggtcaagc ggccgagttt gtcatacacg 1243501 caggatgcct ggaggaggct gaaaaaaaat aaattagcga tggccggact ctttattctt 1243561 ttatttcttt ttgtcatggc agttatcggg ccctttttat cgccccatag tgtcgtacgc 1243621 caatcgctga cagaacaaaa tcttccgccc tcagccgatc attggttcgg caccgatgaa 1243681 ctcggccggg atgtgtttac ccgaacatgg tatggcgcga gaatctcgtt gtttgtcggc 1243741 gtgatggcag cactgattga ttttttgatc ggtgtcattt acggaggcgt tgccggctat 1243801 aaaggcggca ggattgacag cattatgatg cggattatcg aagtgctgta cggactgccg 1243861 tatctgcttg ttgtcatttt gctgatggtg ctcatgggac cgggactggg cacgattatt 1243921 gtggcgctga ctgtgaccgg gtgggtcggc atggcgagaa ttgtaagagg ccaggtgctt 1243981 cagattaaaa attatgaata tgtactcgcc tcgaaaacct ttggcgcgaa aacctttcgc 1244041 atcatccgga agaatttgct gccgaatact atgggagcga tcatcgtaca aatgacatta 1244101 accgtacctg ccgccatatt cgcagaatca tttttaagct ttctcggcct gggcatacag 1244161 gctccgtttg caagttgggg cgtgatggcg aatgacggcc tgcctacgat tttatctggg 1244221 cattggtggc gcctgttttt tccggccttt ttcatatctc tgacgatgta cgcgtttaat 1244281 gtgctggggg acggattgca ggatgcgctt gaccctaagc tgaggaggta gctgtatgga 1244341 aaaagttctg tcagtccaaa atctgcacgt gtcttttacg acttacggcg ggacggttca 1244401 ggcggtcaga ggggtgagct ttgatttgta taaaggagaa acctttgcga tcgtcggcga 1244461 atccggctgc ggcaaaagcg ttacctccca aagcatcatg ggcctgcttc cgccttattc 1244521 ggcgaaggtg acagacggca ggattctatt taaaaacaaa gacctttgcc gtctctctga 1244581 caaagaaatg agaggtataa ggggagccga catttctatg atttttcaag acccgatgac 1244641 ggcgttaaac cctacgctga ctgtcggcga ccagctgggg gaagcgctat tgcgccacaa 1244701 aaaaatgagc aaaaaagcgg cacggaaaga ggtgctttcc atgctgtcat tggttggtat 1244761 tccagatccc ggagagcgcc taaagcaata tccccaccaa ttcagcggcg gtatgagaca 1244821 gcggattgtc attgcgatgg cgctgatttg cgagcctgat atcttaattg cggatgaacc 1244881 gaccaccgcc ctggatgtaa ccattcaggc acagatttta gagctgttta aagagattca 1244941 gagaaaaacg gatgtgtctg tcattctgat tacgcacgat ttaggggttg ttgcccaggt 1245001 agctgacaga gtcgcagtca tgtatgccgg gaaaatggcg gaaatcggca caagaaaaga 1245061 tattttttat cagccgcagc acccatatac aaaaggcctg ctgggctctg tcccgcggct 1245121 ggatttaaat ggcgctgagc tgaccccgat tgacggaacg ccgccggatt tattttcgcc 1245181 tccgccgggc tgcccgtttg ccgcccgctg tccgaacagg atggttgtgt gtgacagggt 1245241 gtacccgggc cagacgatca gatctgactc gcacaccgtc aactgctggc tgcaggatca 1245301 acgagcagag catgcggtgc tgtcaggaga tgcgaaggat tgaacatgaa aagggggaag 1245361 aggatgaaac gagtgaaaaa gctatggggc atgggtcttg cattaggact ttcgtttgcg 1245421 ctgatggggt gcacagcaaa tgaacaggcc ggaaaagaag gcagtcatga taaggcaaaa 1245481 accagcggag aaaaggtgct gtatgtaaat aatgaaaatg aaccgacttc attcgatccg 1245541 ccgatcggct ttaataatgt gtcatggcag ccgttaaata acatcatgga ggggctgacg 1245601 cgtcttggca aagatcatga gcccgagccg gcaatggcgg agaaatggtc tgtttcgaaa 1245661 gataataaaa cttacacatt tacgattcgg gaaaatgcga aatggacaaa cggagatcct 1245721 gtaacagccg gagacttcga atacgcgtgg aagcggatgc ttgatccgaa aaaaggcgct 1245781 tcatcggcat tcctaggtta ttttattgaa ggcggcgaag catataacag cgggaaaggg 1245841 aaaaaagacg atgtgaaggt gacggcaaag gatgatcgaa cccttgaagt tacactggaa 1245901 gcaccgcaaa aatatttcct gagcgttgtg tccaatcccg cgtatttccc ggtaaatgaa 1245961 aaggtcgata aagacaatcc aaagtggttt gctgagtcgg atacatttgt cggaaacggc 1246021 ccgtttaagc tgacggaatg gaagcatgat gacagcatca caatggagaa aagcgacacg 1246081 tattgggata aggatacagt gaagcttgat aaggtgaaat gggcgatggt cagtgacaga 1246141 aatacagatt accagatgtt tcaatcaggg gaacttgata ccgcttatgt ccctgctgag 1246201 ctgagtgatc agctgcttga tcaggataac gtcaatattg ttgaccaggc gggtctctat 1246261 ttctatcgat ttaatgtcaa catggagccg ttccaaaatg aaaacatcag aaaagccttt 1246321 gcgatggctg tggatcaaga ggaaattgta aagtacgtca cgaaaaataa tgaaaaaccg 1246381 gcgcacgcct ttgtatcgcc tgggtttacg cagcctgacg gcaaagattt ccgtgaagca 1246441 ggcggagacc tgatcaagcc taacgaaagc aaagcgaagc agctgctcga aaagggcatg 1246501 aaggaagaaa actataataa gcttcctgcg atcacgctta cttacagcac aaagccggag 1246561 cataaaaaga ttgccgaagc tattcagcaa aaattgaaaa atagccttgg agtcgatgtg 1246621 aagctggcca atatggaatg gaacgtattt ttagaggatc aaaaagcgct gaaattccaa 1246681 ttctctcaaa gctcattttt gcctgattat gcagacccta tcagttttct ggaagccttt 1246741 caaacgggaa attcgatgaa ccgcacaggc tgggccaata aagaatacga tcagctgatc 1246801 aaacaggcga aaaacgaagc cgatgaaaaa acacggttct ctcttatgca tcaagctgaa 1246861 gagctgctca tcaatgaagc gccgatcatt ccggtttatt tttataatca ggttcacctg 1246921 caaaatgaac aagtaaaagg aattgtccgt caccctgtcg gctatatcga tttaaaatgg 1246981 gcagataaaa actgatggag gcgattgagg aaatactgct tctttatgcg aaggagcggt 1247041 attttttctc tttcttgcac gtatacgtag ggtgcagagc aaatgaaagg agtgttttcg 1247101 ttgaattaca agccgaaagc gttgaacaag ggtgatacag tcggagtgat cgcgcccgca 1247161 agtccgccgg atccaaaaaa gcttgacacc gcgcttttat ttttagaaga gctcggtctt 1247221 caggtgaagt tgggcaaggc gctgaaaaac cagcacggct atttagcggg acaggatgat 1247281 gagcggctgg cggatctcca tgagatgttc agagacgatg aggtaaaagc agtgttgtgc 1247341 gcatgcgggg gttttgggac aggacgtatc gccgcgggca ttgatttcag cttgatccgc 1247401 aaacacccta aaatcttttg gggatacagc gatattacgt ttttacatac tgccattcat 1247461 caaaacacag gtcttgtcac tttccatggc ccgatgctca gcacggatat tggccttgac 1247521 gacgttcacc cgctgacaaa agcgtcatat aagcagctct tccaggagac ggaattcacc 1247581 tatacagaag agctttctcc gctgaccgag cttgttcctg gaaaagcgga aggcgagctt 1247641 gtcgggggaa atctgtcttt gctgacgtct acactgggca cgccatttga aattgatacg 1247701 agaggaaagc ttctgtttat tgaagatatt gacgaggagc cttatcaaat cgaccggatg 1247761 ctgaatcagc tgaaaatggg ggggaagctg acggacgcgg cgggaattct agtttgtgat 1247821 tttcacaatt gtgtcccggt gaagcgagag aagtctctct cgcttgagca ggtgctggaa 1247881 gactatatta tttctgcggg caggcctgct ctgagaggat ttaaaatcgg ccactgctcg 1247941 ccaagtattg ccgttccgat cggtgcgaaa gctgctatga atacagcaga aaaaacagcc 1248001 gtaatagagg cgggcgtttc agaaggggcg ctgaagacat gaaaatcatt cgaatcgaaa 1248061 caagccgaat cgctgtcccg ctgacaaagc cgtttaaaac cgcacttcgc actgtgtata 1248121 cggctgaatc agtcatagta aggattactt atgacagcgg tgcagtcgga tggggagaag 1248181 cacccccgac gttagtgatt acaggagaca gcatggatag cattgaaagt gccatccacc 1248241 atgtgttgaa gccggcattg cttggaaaaa gcctggcggg ctatgaggcc attctgcacg 1248301 acatccagca tcttcttaca ggaaatatga gcgcgaaggc tgctgtagaa atggctctat 1248361 acgacggctg ggcgcagatg tgcgggctgc cgctttatca aatgcttggc ggatatcgag 1248421 atacgctgga aacagattat actgtcagtg tcaactcacc tgaagagatg gcagctgatg 1248481 ccgagaatta tctcaaacaa ggctttcaaa cgctgaaaat aaaggtcgga aaagatgata 1248541 ttgcaacaga tatcgcccgt atccaggaaa tcagaaaacg tgtcggatca gctgtgaaac 1248601 tgcgtttaga cgctaatcag gggtggaggc cgaaggaagc ggtaactgcc attcggaaaa 1248661 tggaggatgc gggcctaggc attgagcttg tcgagcagcc tgtccataaa gatgatctcg 1248721 ctgggcttaa aaaggtgaca gatgcaacag atacgccgat tatggctgat gaaagtgttt 1248781 ttacaccgcg ccaggcgttc gaagttctgc aaacccggag cgcagacttg atcaatatta 1248841 aattgatgaa agcgggcggc atcagcggag cagagaaaat taatgccatg gcggaggcct 1248901 gcggggtgga gtgtatggtc ggcagcatga tcgaaacgaa gctgggcatt acggccgcgg 1248961 cgcattttgc ggcaagcaag agaaacatca cacgctttga ttttgacgcg ccgctgatgc 1249021 tgaaaacaga tgtattcaat ggcggcataa catatagcgg cagcacgatt tcgatgcctg 1249081 gcaaaccggg cctcggaatc atcggggctg cgcttttgaa aggggaaaaa gagcaatgat 1249141 gcacactgtc atatcagcag tggccaacat ctggacagcg cctgattcac ctcgtccgtc 1249201 tgatcaattc atgcttcaac cgactgtaat gatcagagac tggctggagc gcatgacgta 1249261 tgatgaacgg cttggattat gtacagacaa tgtaatccaa actcaggttc tctttggcga 1249321 aaaggtactt gtgacggcgg aacaggggga atgggtttct gtgatcgtgc ctagccagcc 1249381 atcccgaaag gatccgcgcg gatacccggg ctggatgaaa aagtaccagc tggaaaaaac 1249441 aaagcccatc catacacaac acgatgtgat gatcagcaaa cctgctgcct ttttgtacag 1249501 aagcaatggg gaaaaggaga tcgaattaag ctttttgaca gttctgcccc ttattgcaaa 1249561 agaaaacgga tattttaagg tttcgaccgt ttttggggaa aggtttgtga ggcaaagtga 1249621 tgcagtgcct gtcagccaac agaaagggac tgctgaagac atcattcaaa cgggtgcgtt 1249681 ttttcttggc cttccctacc tgtggggagg gatcagcggg tttgggtttg attgctccgg 1249741 atttatgtac agtatattta aggcgaatgg atacagcatc ccccgtgatg cgggagatca 1249801 ggctaaggca gggaagggtg tcccgcttga tgatatgaaa gccggtgatc tgctgttttt 1249861 tgcttatgag gaaggaaaag gagcgattca tcacgtcggt ctgtatgtag gcggcgggaa 1249921 aatgcttcat tctccaaaga cagggaagtc aatcgaaatc ctcacattaa cagagacaat 1249981 ctatgaaaaa gaattatgtg cggtgcgccg ctgtttttca gaataaggag ggagacaaat 1250041 gaggcgactg cctttgttag aggtcagcca gctgaaaatg cattttgacg cagggaaaaa 1250101 gcggacagtc aaagctgtcg acggggtcac ctttcagatt cgtgaaggag aaacgttcgg 1250161 gctagtcggg gaatcagggt gcgggaaatc aaccttgggg agagtgctga tgcgccttta 1250221 tcagccgaca gaaggaagcg tgacataccg cggcacaaat cttcatgcac taagtgaaaa 1250281 agagcagttt gccttcaacc gcaaactgca gatgattttt caggaccctt atgcttcact 1250341 taacccgcgc atgaccgttc gagaaattat tttggagccg atggagattc ataatctcta 1250401 caatacccat aaagcacggc ttctcgtcgt ggacgagctg cttgaggcag ttgggcttca 1250461 ccccgatttt ggcagccgtt atccgcatga attcagcggc gggcaaaggc agagaatcgg 1250521 gattgcgaga gcactgtcgc tgaatcctga atttatcgtg gcggacgaac cgatttctgc 1250581 acttgatgtc tctgttcaag cgcaggtggt caacctgctg aagcggcttc aaaaagagaa 1250641 agggcttacg tttttattca ttgcccatga tctttcgatg gtgaagcata tcagtgacag 1250701 gatcggtgtt atgtacttag gacacatgat ggaaattaca gagagcggca ccttgtatcg 1250761 tgaaccgctc catccctata caaaggcgct tttgtcctcg attccgattc cagatcctga 1250821 attggaggac aagcgtgagc gtattctctt gaaaggggag ctgccgagcc cggtcaatcc 1250881 gccaagcggc tgcgtgtttc gtacccgctg tccggaggcg atgcctgaat gtggagaatc 1250941 tcgtccccag cttcaagaaa tcgaacccgg ccgttttgtc gcttgccatt tgtatcgaaa 1251001 tgctgaaacg aaggaaaaag taagataaat aaaaagagtg gctccttttt actagagcca 1251061 ctccatttgt ttatacttga tgtaaaaact ttacacaaac cgggtaaggg acagaaaccg 1251121 ttgatgggag gagtgtcaat cggccggttt ctttgtctct ttcaaacaag acaaggttgc 1251181 ctgtttcttc atttgaagca acgaggaacc cttccgttgg gtcaaataca aagtcacgag 1251241 gccagtttcc ttctgtcgac actctttcta cgaaagccag ctctcctgaa tattgattca 1251301 cttcaaatac ggcgatactg tcatggccgc ggtttgcgac ataaacaaaa cgtccgtcct 1251361 gcgtgacatg tattgcgctt ccctggctgt tatctgtaaa atcatcaggg atggcagaaa 1251421 cgacttggat ttctctaaat tcgccggctg tcgggttgta ttcaagcgca atcacttcat 1251481 tgcttaattc tgtcatgaca taagcgtatt tttctttcgg atgaaaagcg atatggcgag 1251541 gtcctgcacc gggagcgaag gaatggcttc cggattcagt caacacaccg tctttaagct 1251601 tataggtgta gagcttatct atacctaaat caaccgctac cacataattg tgttcaggtg 1251661 tgaaccccgc gtagtgtgta tgcggttttt cttgtctttc gtgcggccct tttcctgtgt 1251721 gagcggcctc tgaaacaggt gattgcaagc tgccgtcttc ctgaaccgga aaaacgtgta 1251781 ccttcccgct gtgataattg gcagtcagta cgaattgatt ttgatcatca acgcttacgt 1251841 ggcatggcga agggccatca attaactgat gattcagaaa tgtcaattcg ccgctgtttt 1251901 tatcgatttg ataggcagca actccgcctt ggccgtctgc tttttcgatg gaataaagga 1251961 tggtgttgtt tttattcgtc gccacatatg tcgggttgcc cagcttagcg gccagctttg 1252021 gctcgctgag tgcttttttc tcagtatcaa gctcaaatga ataaattcct tcgcttccgc 1252081 cttttgtata tgttcccaca tatcctatgt attttgtcat gcgatttccc ccttaaaaat 1252141 gatgtcacct ctatattaac gtatcttgat aaaataagct gttcaaaaca tgaaaaaggg 1252201 gaagattctt cattcgcctc gaatcagcgg cattgtgcag cacctgaagg agccgcctga 1252261 tttaataatt tctgacaggt caatttcgat aatgtgatag cctcttttcg atagctgttg 1252321 attgacatgg cggttgccag ggagactgat gatcgttttt tttccgattg aaaggacgtt 1252381 ggtgccaagc gtaaattgtt cgtcctcggg cacctcaata agatcataac gttttgccag 1252441 catatcggct gcatctggct caatggcctg tgaataaatt aacgcttcgc tttcagatat 1252501 aatgttaaat acgcagtcca aatgcaaaaa tttttcatga agcttcactg gaacgatcgt 1252561 atattcagga agtgcctctt ctagctggcc gatagctgaa atgtcggtgc gctggctgat 1252621 tccgacatag acaatgtcat catcgataat gacgtctccg ccttcaatac tcgtatcaag 1252681 catgcgggtg taagagatac cttggctgtg aaaaaaatct tttataacgg cttcttctcc 1252741 ttggcgaatc ggttcagtca tgcttgacag aaaggctttt tctccgatga caaatcctat 1252801 gtccctagta aaaacctgtt ctgggagtcc gtcgcgaacg ggcaaaagga cgacctcaac 1252861 gttgtgtgac ctaagtgcct ccactaagcg gctgtgctgg tcgttagcgg tttttacatg 1252921 aatattgtca tcttcaaaat gtttttgtgt ttcgtttata acatctttta tggtcatgtg 1252981 ctcaggtttg cataagatca ctttttgaag tgtgccgtat tccgttcggc ataccgtttt 1253041 gtgctgagat ttcgggatgg atacgtccat ttgtttttcc tcctaaagtg tgaagaatac 1253101 atttattatt ccctcatcat gaaaatcatt aaaccatttt aaattttaga caaatggaag 1253161 agaatattgt ttaataggag aatataagtg catttagcta aaagatcaga catcaaaggg 1253221 gagaaaggta tggaaacacc ggaaacaaga ttttgtaaag agtcaaaggt tgtgaaaacc 1253281 agcagggtgt tcccgcttga cacgaacaac cataatacgc tgtttggcgg aaaattaatg 1253341 agctacatag acgacattgc ctctatttca gcggcgcgcc attgcagacg tgaaacggta 1253401 acagcttcaa tggattctgt agatttttta aagccgatcg ggcaaaagga ttctgtctgc 1253461 ctagagtcat atgtgacatg ggtcggcaca tcttccatgg aagtatttgt gaaagttatt 1253521 aaggagcatt tgatgactgg cgaacgggaa ctcgctgcca catccttttt gacatttgtc 1253581 gcattagatt caaatggcaa gccggtgcct gtaccgaggg ttgtaccgga aacagaagaa 1253641 gaaatcatgc tgcataatac agctgtacag cgtgctaatg aacgtaagaa ccgcaagaga 1253701 cacagccagg cgcttgcaaa tgcgctcgga actgataagc cttggtgaac gttaaaccca 1253761 aaacataagt tgttttgggt ttttttgtac ttttcaatgg tgattattac aatggttagt 1253821 ccgtttttgc taggggattc tataaaaaag caacaaatgt catgttaaat tgataatttt 1253881 gtgacaactt tattaaagat tcattttaga tatatctttt attcgtaaga tcatgtattt 1253941 taaagatata ttttaaatac atcttttcga aaggattgtt tataaaatgt tagataacaa 1254001 aacaatcgaa attattaaaa gcactgtacc cgtattgcaa cagcatggag aaacaatcac 1254061 tggccgtttt tacgatcgga tgtttcaaga ccatccagag cttttgaaca tttttaatca 1254121 aacaaaccaa aagaaaaaaa cacagcgaac tgcactggca aatgccgtta ttgcagctgc 1254181 ggcaaacatt gaccaattag gaaacatcat tccggttgtc aaacaaatcg gccacaagca 1254241 ccgcagtatc ggaattaagc ctgagcacta cccaatcgtc ggtaaatatt tgctgattgc 1254301 gattaaagat gtattgggag acgctgcaac tcctgacatt atgcaggcat gggaaaaagc 1254361 gtacggagtc attgctgacg cgttcatcgg aattgaaaaa gacatgtatg aacaggctga 1254421 agagcaagcc ggcggctgga aggagtataa gccattcgtt atcgcaaaaa aagagcggga 1254481 aagcaaagaa attacatcct tctatttgaa accggaagac agcaagccgt tacctgaatt 1254541 ccaagcaggg caatatatca gcatcaaagt gcggattcct gattctgaat atacgcatat 1254601 ccgccagtac agcctgtctg atatgccggg aaaagactat tatcgaattt cagtgaagaa 1254661 agatggtgtc gtgtcttcct acttacacga tgggctgcag gagggagatt caatagagat 1254721 cagcgcaccg gcaggggact ttgttttaga tcatgcatca caaaaagatc tcgttttgat 1254781 cagtgccgga gttggcatta caccaatgat cagcatgctg aaaacatctg tttccaaaca 1254841 gcctgaacgg caaattctgt tcattcatgc ggcgaaaaac agtgaatatc atgcattgcg 1254901 ccatgaagta gaagaagcag caaaacattc tgctgttaaa acagcatttg tgtatcgcga 1254961 gccgacagag gaagaccgtg caggtgatct gcattttcat gaaggacaga ttgatcagca 1255021 attcctcaaa gaactgattg ccaacacaga tgcggattac tatatttgcg gttcaccgtc 1255081 gtttattacg gcaatgcata agcttgtatc agagctcgga tcagcgccgg agtctatcca 1255141 ttacgagcta ttcggcccgc aattaagttt ggcgcagtcc gtttgaacac atacatgaaa 1255201 ctcttctcct ttcagagaag agttttttat tgagatataa gaaggcagac aagcgccggt 1255261 ttctacatcc ggacaatcac agacccgctg ccatttgtgc atacacggtt ttgctgttct 1255321 tgcattgttc tcagcaattc attgtttacc tcaatcgctc taattagttg cttcattctt 1255381 agctccaaac cggccagcct gtcgattgtt tgctgctggt agccctcggg ttggggagcc 1255441 aatggcagat caaagggcca aagggtattc gacttctgat ttttcatatt gcgtattgcg 1255501 cctccaatcg gtgtcacttt ctattatgtt atgttcaggc gatatgcacg ttcgcctaga 1255561 cactgatgca tagagggcct gccacggggc acaataggct caatatgacc agcggatgga 1255621 ggtaaagatc ggtgttatgg atggtatggg tatttttact gaagccagtt atcgtatttt 1255681 cgattgcata tattttgttt cggcttgccg gtaaaaaagc tgtgtcacaa atgaacaatt 1255741 ttgacctgct tttgaccttc gcaatcggaa ccattatcag tgagccgatc cttacatcca 1255801 agctgccgat gtcaatttat tatgcgggtg cttttttggt gctttatctt atcatgagca 1255861 agctctcttt atctaataaa tggcgatggc tcctagtcgt gagcccgact gtcctaatcc 1255921 gaaacgggga tattgatgaa cgcggccttc gtaaagaaag gctgactgtt aatgagctgc 1255981 tcggaaagct gagggaaaag ggctatgccg acccggctga cattgatctt gctatcattg 1256041 aagaaacggg agaagtaagc gtcatcccga aagaggaagc gagagcggtg caggtgcggg 1256101 atttgaatat ggaagctgaa cggaatttta tcccgattcc gctcatactg gatggcgaaa 1256161 tccttgatca taatttgaaa tatctccaaa aaaaccgatc ctggctgttt gagaagcttg 1256221 aggaaaaagg gtacagcccc aaactgctgt cttcgattat ccttggcacg atgaatgcac 1256281 gcggtgatat atcccttgat ttaaataccg ctaatgaacc gcagcatgat ccttacttat 1256341 ataaaccggg aaataacaat taagatggct ctctcttgta atgagagctt ttttcttttt 1256401 taaagggaat ttttgtttgg tgtcaaatgt acctagttag gaggggaact gaacatgaag 1256461 gacttatcca taagaaacga catggcgcca acggtcagtt tgctgtattc cgcagtggaa 1256521 gaaaacagtc tccgtctggc ttccatcgta agccatatga cacacagtga actttactat 1256581 aaggggcgct gccaaacaaa aaacagcacg gctcagcttt tgcaccatat cacaaatgtt 1256641 gatatcagat gggtctggcg tatcaaggaa aatcggatcc cggaccatat tgaacaggca 1256701 tacggcccga tgacagatga aagcggacgg ctgcctgaac cggtgaatca gccagactta 1256761 gatgaactcc tgaaaagaca tcagcatgta gtagagaagc tgaaatcggt atgcttcact 1256821 ttaactgaaa atgctttgaa ccagccgctt tccttcgaag gtgacaccgc gacgatacga 1256881 tggggaattt ggcatatggc agatcataac cgctatcatc aggcacatat tgaagctctc 1256941 aaaaaagaat ggaagcagga tgtggcgaag tatgaacgct aaaacgaagc ttgtgactga 1257001 tcgaattcgt ttgcgctgta tggaagatcg ggatcaagcc actttgtttg ggctgctttt 1257061 taatgatcct gacgtcatga catattattc cggtttaaaa gataagaggc aaacccgcga 1257121 gtgggtcaat tggaaccaac gaaatgaaaa agggtacggc gttagtctgt ggatcgccga 1257181 agataagcgg acaggggagt ttttggggca atgcggcatc gttccccagc agatcgaaaa 1257241 tcaaaccgta atggaaattg gctatatgtt tgcccgccgc cactggggga acggctatgc 1257301 gcaagaagcg gctcgggcct gtctggacta tggctttaac gagcggcagt tcggcaaaat 1257361 ggcggctttg attgatccgg gtaacaaagc gtccatacgg gtagcggaga aaatcggcat 1257421 gcattacagc aaaacgatca gaaaatggaa taaaccgatc gcggtatatg aaagaaaatc 1257481 ttacaattga aagatagagc tgagtttagt atcatgatat catgtaaagt tttctagggt 1257541 tccgcatgtc aattgacatg gactggtccg agagaaaaca catacgcgta aatagaagcg 1257601 cgtatgcaca cggagggaaa aaagcccggg agagtcaatc tcatgtgaga cgactgtccg 1257661 gggttttttt gttttcggag aatcttaata gatagaaagg aatgactcaa aatgaaatgg 1257721 ggattggtcg tgcttgccgc tgttttcgag gttgtttggg tgataggctt aaagcacgct 1257781 gactcagcct taacatggag cggcactgcc atcggcatca tattcagctt ttaccttcta 1257841 atgaaggcga ctcacagtct gcctgttggt accgtgtatg ccgtctttac cgggctcggc 1257901 acagcgggaa cagtacttag tgaaatcgtt ctttttcatg aaccggttgg atggccgaag 1257961 ctattgttaa ttggcgtgct cttaatcggt gtaatcgggt tgaagcttgt gacacaggat 1258021 gagacagagg aaaaaggagg cgaggcataa tgctgcactg gatcagttta ttgtgcgcgg 1258081 gctgtttaga aatggccggc gtggccctta tgaatcaata tgcgaaagaa aaaagcgtga 1258141 aatgggtgct gttgatcatt gttggttttg ccgcttcatt ttccttgctg tcgtacgcaa 1258201 tggaaaccac tccgatggga acggcttacg cggtctggac aggaattggc accgccggcg 1258261 gggcgcttat cggcatcctc ttttacaagg agcagaaaga cgccaaacgg atcttcttta 1258321 tcgcgttgat tttatgctca gcagttggtt taaaaattct gtcataaatt gatttttatc 1258381 aaatcttcag tataatggat aaatagttta gacttacaaa gataagaggg attattcatg 1258441 aaatcatata tgactcagcg gttggacgaa taccgtgacg gaaatgagga taaaggtcgg 1258501 ctcttggtca gctgccccga tcagccgggt atcgtctctg cagtttccgc gtttttattt 1258561 gaacacggtg ccaatattat agaatcaaat caatatacga cagaccctga aggcggccgg 1258621 ttcttcctga gaatcgaatt cgactgcgca ggcattcgtg aaaaaaaatc atcacttcag 1258681 gcagcgtttg cctctgttgc ggaaaaattc gacatgacat ggagcttaac tttggcgagc 1258741 gaactgaagc gtgtcgccat tttcgtttca aaggagctcc actgcctgca tgagctgatt 1258801 tgggaatggc aaaccggcaa cctgatggcg gagatcgctg ttgtcatcag taaccatgag 1258861 gaagcgagag agctggttga gcgcctgaac attccattcc actatatgaa agcgaacaaa 1258921 gacatcagag cggaagtcga aaagaagcag cttgaactgc tggagcagta cgatgttgat 1258981 gtgatcgtgc tcgcacgcta tatgcagatt ctaactcctg attttgtttc ggctcatccg 1259041 aatcgcatca tcaatatcca ccattcattc ctgccagctt ttatcggtgc gaatccgtac 1259101 aaacgggcct acgagcgcgg cgtgaaactg atcggtgcga catctcatta tgtgacaaac 1259161 gatcttgatg aagggccgat cattgaacag gatattgagc gtgtggacca ccgcgataat 1259221 gcggaagcgc tgaaaaacat cggaagaaca attgagcgca gcgtgcttgc ccgtgctgtg 1259281 aaatggcatt tggaagaccg tgtcatcgtt catgaaaata aaacaatcgt ctttaactag 1259341 actgcaagag gcccgcgcaa tgcgggctat ttttgatgac aaaaaacctt gacaagtgtc 1259401 ttttttcttt gcataatata aaaaaatcat tgagcgttga agaggattag taagcagacc 1259461 tttctgtgac agagagcaaa atgaatcgct gaaacatttt gccgcatgaa acctgccgaa 1259521 cctgccttgg agtcctaggg ggaaaaccta ggcgcataac ctggcgttac aggagagcgg 1259581 agcgtgcaca agcgcgttca atcaaggtgg taccacggaa acccatttcg tccttatgaa 1259641 tcaggatgaa atgggttttt ttattgtaga agagccgcgg aggagaataa atgaaaaaac 1259701 aaagaatagt agtgaaaata ggaagcagtt cgctcacgaa tagcaaagga agcattgatg 1259761 aggcaaaaat cagagagcat gttcaggcga tttccgtgtt aaaaaaagcg gggcatgaaa 1259821 tgattctgat tacctcgggt gccgtagcgg cggggttttc cagcctcggt tatccatccc 1259881 gtcccgttac catcaaagga aaacaggcgg cggccgcggt cggacaaaca ctgttaatgc 1259941 agcaatatat gaatcaattt aaacaatact cactgactcc gggacaaatc cttttaacga 1260001 gaaatgattt ttcgaaaaga gaacggtatc gaaacgcgta tgctacgata atggaattat 1260061 tagagcgggg cgtcattccg attatcaacg agaacgattc tacatctgtt gaagaattga 1260121 cattcggaga taatgatatg ctttctgcgt tagtcagcgg attgattcac gcggaccagc 1260181 tcatgattct cactgacatt aacggactgt atgatgccaa tccaaatgaa aatcctgagg 1260241 cgaaacgatt tgattatttg ccagagatca cgcctgaatt gcttggatat gcaggttcag 1260301 ctggatcaaa ggtcggcacc ggcggaatga aatcaaagct gttagccaca caaaccgcgc 1260361 tgtctctggg agtgaaagta ttcattggaa ctggcagcgg agagcaaaaa cttgcggaca 1260421 ttttggacgg caggggagac ggcacttata tcggagacaa agaactatct tcggttaaca 1260481 acacaaggca gtggattcag ttccactcgc cgatatcggg agaaattatc attgatgcgg 1260541 gtgccgaaga ggcgatgatc cataatggaa gcagcctttt gcccgctgga gttgtgggcg 1260601 tgaacggaag ctttccgaaa ggggcggttg tggaagtcag gggaccgggc ggcgtgatcg 1260661 gcaaaggcca aactcattac tcctccgagg agattatgga ggctaaaggc aaacgcagtg 1260721 acgaacttga ttttgagaaa acgtttgagg ttattcatag gaatgactgg gtcaatgtaa 1260781 aagactagga ggcggaaaaa tgagtgaagt ttctgtaaaa gcgaagctgg cgaaagaagc 1260841 agcagccgaa atgatcatga aaacaacagc cgagaaggat gaggcgctca gcctcattgc 1260901 aaacggactc cgcaaagaac tggattttct cttggcggag aatgcaaaag acattgtgaa 1260961 cggaaaagag aatggtttaa caccggacat cattgaccgt ctctcattgg atgagaaacg 1261021 gatacgcgat atcgcggacg cggtggagct cttaatcgac ttagcggacc caatcggcga 1261081 ctctcttgaa acgattgaaa aagaaaacgg cctgtttatt gaaaaaatcc gtgtgccgct 1261141 cggtgtcgta ggaatgattt atgaggcgag gccaaacgtc acagttgatg cggctaccct 1261201 ttgcctgaag acagggaacg cggttgtgct gcggggaagc tcctcagcca tccacagcaa 1261261 caaagcgctc gtcagtgtca tttacagagc acttgagcaa tcagcgcttc cgattcacgc 1261321 tgtgcagctg attgaggata cgagcagaga gacagcaaaa gagctcttta cgttaaatga 1261381 tggcttagac gtattgattc cgcgcggagg caagaaactg attgatctcg ttgtgagaga 1261441 atcaacagtt cctgtattag aaacgggagc aggaaactgc cacatattca ttgacgaaac 1261501 agccaaaccg caaatggcag aaaaggttgt tgtaaatgcc aaaacgcagc gcccttctgt 1261561 atgcaacgcg attgaatcat tgctgattca caaggcttgg gcaagacagc acggaaaaga 1261621 attgctggac cagctggaaa acgcgggagt tgaaattcgc ggtgatgaat tggtatgtga 1261681 acttcatcct tcaagcaaac aagcatcaaa agaagattgg gaaaccgaat ttttagcgcc 1261741 tgtcctcagc gtaaagacgg ttgaaaacgt ccaagaagct gtaaagcata tccaacaata 1261801 cggcaccaat cattctgaag cgattttaac tgaaaatgac aaaaatgcgg tatattttca 1261861 aacggctgtc gatgctgccg ctgtctatca taacgcgtca acccgcttta ccgacggctt 1261921 tgaattcggc tacggagccg aaatcggcat cagcacgcaa aagcttcatg caagaggacc 1261981 gatggggctt cctgcactga cttctacaaa atacatcatt aaaggaactg ggcaaatccg 1262041 tgaatagcgg ggtaatgttc aatgaaaaag cttatctcat tacgagataa gcttttttat 1262101 acgcgaaaaa ttgacatttc aaatttaatt gtgtacaatt taattgtata aaatatattg 1262161 ggggaatgaa aaatgagtca gccattattt accgcaactg tttcagcggt aggaggaaga 1262221 gaaggaaagg tcatttcatc agaccgcgtt cttgagcttg atgtcgcaat gccggggaca 1262281 ccgagagcca agaaattaga aaaagcgaca aatccagagc agctgtttgc agcaggttat 1262341 gcagcttgct ttgacagcgc cctgcagctt gtcgcaagaa cagaacgggt aaaagtagag 1262401 acagaggtta cagcaaatgt tagcctgtta aaggatgaag cggaccaggg ctataagctg 1262461 ggtgtgacgc tgcaagtaaa aggagaagga gtcagtgcat cagaattgga ggcgcttgtg 1262521 aaaaaagcgc acggcgtctg cccgtactca aaagcaacct ccggaaatat tgatgtgaca 1262581 cttgaagttg ctgaataaat aaaaagagga tgcctgtaca aggcatcctc aatttttttg 1262641 atgaagtgtt tccagtaatg tatatagagc ggactttaac tgtttgagat cctccccaga 1262701 ctgctttgag agccccagaa ttgtccctgg aatgtcaacc gctttttctt ttaataacgc 1262761 tccgtcctct gtcaggctga tcaacacgga ccgctcatcc tcttcagatc tttttctcgt 1262821 aatcaaaccc tgttgttcca ttcgtttaag catcggagtg agcgttcctg aatctaaata 1262881 cagctgttcg cccatttttt tgacagtaag cgtttcatgt tcccataaca aaagcaaagc 1262941 caaatattga gggtatgtta tattcagctt atcaagcagc ggcttgtatt gctttgtcat 1263001 ctcccgcgaa ctcgcatata gcaaaaaaca aagctgattc tccaatttca tatgatcaaa 1263061 tttattttcc attttgttca ccaactcttt tttgtcattc gattctattg tatctgaaaa 1263121 acctcacttt tcctattctc ggcaaacata gcatgtttaa aaagatcaga aagggaaata 1263181 taacaactag atacaaataa ggaggttggg aaatatggca ctatttacag caaaagtaac 1263241 cgcgcgaggc ggacgagcag gacatattac atcagatgac ggtgttcttg attttgatat 1263301 tgtcatgcca aatgccaaaa aagaaggaca aaccggcaca aatccggaac agctctttgc 1263361 ggcagggtat gctgcatgct tcggcggcgc gctcgaacac gtagccaaag agcagaatat 1263421 cgaaattgat tcggagattg aagggcaggt cagcctcatg aaggatgaga gcgacggcgg 1263481 gtttaaaatc ggtgtcacac ttgttgtgaa cacgaaagat ttagatcggg aaaaggcaca 1263541 agagcttgtc aacgccgctc atgaattctg tccttactca aaggcaacca gaggaaatgt 1263601 tgatgtaaaa ctagaattaa aataatgacc ggcatcctga ggattctcag gatgtttttt 1263661 ggtgtcggac atgcggggcg ggcacagatt tatgataaaa cttcagagaa gcgtttgaag 1263721 catgccttta aaccaaaagt tacagatgaa gcgggtggct ggcacggtgt ctgccgtgct 1263781 gaattgcgcg tatatgctgt tttgtatttg cacagggcat agcggctact tggagaaata 1263841 acaaggacca ggccgcgcat gcctgatcct tttaatattc tttcttattg gcgaagttcc 1263901 gccatgcttg aaacggggat aaatgctctg ttagtgtcac ttgataaaag gggatcgttc 1263961 tttcttcagc aggtttatca atttctttat aaatgaatga atcatcaaac ccggcttcgg 1264021 cagcgtctgt gtgctcagct gcatagaaaa cggctttagg ccgggcccag tagatggcgc 1264081 ccaagcacat tgggcatggt tcacagctcg tatacaaaat gcagtcatca agctggtagg 1264141 ctcctagcac cttacaggct ttccgaatag ctgtgacttc cgcgtgggca gtcggatcat 1264201 tgcttgttgt gacgttgttc tgtccctctg caataatggc tccgtctttc acgataacgg 1264261 ctccaaaagg cccgccgatt cctgcattca ctccttcaca tgcgagagtg acagcccgtt 1264321 ttaagaacgt ttcatgattc atcccaatcc ctcctgtcaa tagagtgtta ttagtatagc 1264381 cgaaaagaat gcaaagaaca ttcttaaaaa agtgcaaaat aaacaaagta tttgggggat 1264441 ttgctaaata agaaaccgat tgtggctgta ttatagaaaa aaaccatctg ccaaatgcag 1264501 atggtttttt caaattatac tagctgtgtc tgctgtgctc ttgcctgttt tgcggcttca 1264561 accatatttt tcaatgctgc aaccgtttct tcctgctgtc ttgttttcaa tccgcagtct 1264621 ggatttaccc agaagcggtc agtcggacag acggcaagcg catcaacgat aatattgtac 1264681 atttcttcag ttgacggcac acgagggctg tgaatgtcat atacaccaag gccaagccct 1264741 ttcaaatacg ggtggttttt taagtaatct aaaaatcctc cgtggcttct gctatgttcg 1264801 attgtaatca catcggcatc aagatcattg attgtatcaa cgatatcttc gaagttgctg 1264861 tagcacatat gtgtatgaat ttgtgtctcg tttttcacgg aagaagtggt taatctgaaa 1264921 gcttctgccg cccaagtcaa atactcatcc caatcgcggg ttttcaatgg aaggccttca 1264981 cgcagcgctg gttcatcgac ttgaatgatt tgaatgcctg cgtcttcaag cgctttaact 1265041 tctttgcgaa gggcaagccc gatttggaag gcgatttctt tcctcgagat gtcgtttcga 1265101 gggaaagacc agtttaagat tgtaaccggg cccgtcagca ttcctttcac atgcttggaa 1265161 gtcaatgact gtgcgtagac tgtgtctttc actgtcatcg gttcaataaa ttcaacatct 1265221 ccgtaaatga ctggcgggcg gacacagcgt gagccgtatg attgaaccca ggcatattta 1265281 gtgaaggcga aaccggccag cttttcaccg aagtattcga ccatgtctgt ccgttcaaat 1265341 tcgccgtgaa caaggacatc aagctccaat tcttcctgaa tatcaatcca tctttttgtt 1265401 tccgcattga taaagttttg atactgttca tcggaccact cagctttccg ccatttttgg 1265461 cgtgcgctcc gcacttcagc agactgcggg aagctgccga tcgttgtcgt cggcaaaagc 1265521 ggaaggccga gagattcatt ttgtagggct aaacgttctt caaacggaat cgggcgcttg 1265581 aagtctttat cagttaattg ctcaagctct ttcttttgtt cagaattggc gcctgttgca 1265641 aactgtttaa gcgcctggat atcagcctta gcctgctgaa tctcttcgct gatcgccgct 1265701 tttcctgata ctaagccttc tttcaaagct gtcagctcgg ccagcttttc ttttgcgtag 1265761 gataatccgt tcaataggtc tttttccaaa tgctcatcag ggtgtttcgc tactggaaca 1265821 tgcagcaggc tgctggaagg ctgaatccac agttcatcaa cttttgcaat gctgagaata 1265881 tcaagaacgg catcgagacg ctcttcaagg tccgctttcc aaatgttgcg tccgtcgata 1265941 acgccggctg ccagcacttt atctgtcggg aagccatgtg ttttaagctg ttccaggttt 1266001 ctgcctttgt cgtgaacgaa atcaaggcca attccctgaa ccgggtaaga gatcagctct 1266061 tcataagcat caacagaatc aaaatacgtc tgcaaaagca cattcaagga tgaaagctca 1266121 cttgtaatgc tttcaaataa ttcttttgcg ccgcgtacat cttcactaga ggcggtaacg 1266181 agcgccggct catcgatttg aacccatttt acgccttctt cttcaagctc tttcaaaagc 1266241 tgtacatata atggcacaag gcgtttttgg atcgcttttg cttcagacgg ttcatagcct 1266301 ttagcaagcg taacgaacgt ataagggccg acaatcacag gctttgtttc cacaccgtat 1266361 tcctgtttga tccggcgata atcttcgagt tgtttgtttc ttgtcagacg gaactcaatg 1266421 ctctcgtcat attccggaac gatgtaatgg taatttgtat taaaccattt tgtcatttca 1266481 ctagatacag cgtctttgat tccgcgggcg atagcgaagt atgtatcggt agcgtcagtc 1266541 aaatgtctga accgtttcgg gatccagttg aagctgactg ctgtgtcgag tacatggtca 1266601 tactgtgtga aatcagaaac aggcacaaca tcaatctgct ggtcaatttg tgtttttact 1266661 gcggataaaa atagttcgtc gatttgcttc aaaaacgtat ctttatcagt actgcctttc 1266721 caatacgctt caagtgcttt tttccattcc cggttcagtc cgattctcgg aaatcctaaa 1266781 ttcgatgttt tgatggttgt cattgtttct cctcctttat atgtaaaaca ctctctttca 1266841 cccgcggata caggctgcta agaggttttc tcacaacaaa aagcctcttt cccatgagag 1266901 aaagaggctt ttctacgtaa aacactgcct ctctcatctc tcagacacaa tctgatggaa 1266961 ttagcaccgt gccttatgag acatcagtct cggcgcgaaa agcagtgcgc cccatttcac 1267021 aatggtatta cggtcggttg ctgttggggt caaaaggcca atccctcgcc caactctcga 1267081 taagagaaaa tgttattaat tttttgaaaa gttgaatcat ttgttggtaa tcttaacagt 1267141 aattcaaatt cattgtcaac atagaatttg aaatttttat ttacatgatg tggtgtatat 1267201 tatataagaa aaataatctt atagggtcaa caaatgtgat tgctctgctt tttctgcgag 1267261 ctcatcagga gctgttaaat acaggaatcc attgcctgcc agcgtttttg caatatcaag 1267321 aggaagtgtc ctgcggatta gctgtgcgaa aacctcagat tcagaaagct ttctttgaaa 1267381 tgattcttct tcatagcttt tgattaaagc aagcgcaccg ctgacatgag gggcagccat 1267441 tgaagtgccg gtcagcttac cgtacttctt gttgggaagg gtggataaga tgttttctcc 1267501 tggtgccaca aggtcaatct ctttattcgc gttagaaaat tctgataatt ctcgcgctac 1267561 agaaacagat ccaactgcaa tcacttcatt ataagctgcg gggtaggaaa gctcttctgt 1267621 gcgttcgtcg ccgtcacctt catttcccgc tgcacaaacg acaagcactc cgtttttcac 1267681 tgcgtttttc actgcttctt ttagctctgg cacatcgctt ggccctccaa gggacattga 1267741 gatgatgtcg actttctgtt ccaccgcgta gttgatgccg ttaattatcc attcgtattg 1267801 tccgctgccg ttctcgccgc caagaacctt cacaatcaat aggcttgcct caggcgcgac 1267861 tccggcaatg cctccgtttg aatcattagc tgcaattgtt ccggcgacgt gtgtgccgtg 1267921 tccgttgtag tcggaaatcg catcttcctt gccgccgtcg tcatccgtga agttctttcc 1267981 gccgatgatt tgatttttta aatcagggtg gcttgtgtcg cagcctgtgt ctaatacagc 1268041 aactttaata tttttgcctt ttaccccttt tgcccacatt tctggcgcct taatcacttt 1268101 aatgccctca ggaagctcgt ttacatccat gatctgctca ttcgtcacat acgggatcaa 1268161 gcggatttca ccattcataa aaaagccctc cttttttatg cttgcaagtg gattcaaggg 1268221 tgttgcctca tattatatga aaaaagcaag cgctcggaca gagccatttg aagcattttg 1268281 aaaaaatagg atacacacca aagaattagt aatcttcaaa atattggatg gcttcaacat 1268341 gtatgactgg gattcaactg taagtcaagt tataatagtg ttggggaaag gagcagtgtc 1268401 atgaaactga atgaaaaatt atatgcattt ttttcagagc atgtggaaca aatggccgag 1268461 gaatggattg aaacgatgga ggaaagtgat ccgaattcgc tttacgccct acataatgca 1268521 acagtaacgg aagaattgaa agagcaggac agagaatttt accggcatct gaattacatg 1268581 tatgttttac cggaaaaaca atttctcgaa gagtttcaag agtgggtcat tgagctgacc 1268641 aacgatcaaa aacatctcga cacaccggtt cagtatgtca ttcgggagtt tatgagaaac 1268701 aggagattat atacgaagta ttttgagaag ttcgcagaag aaaatgaatc agcgtttgaa 1268761 ccgggagaga agcaaaaatg ggcagatttg attgtaaaag tatttgattt caccatttat 1268821 acattcgttg atcacgctga aatgaatgcc aagcagcaat taaacgccca aagagaaatg 1268881 atattggaat taagctcacc tgtcattacc ctgagcaaat caacagctct gctgccgctt 1268941 gtcggtgaca ttgataccga acgggcgaag tttattctgg aaaacacgct tcaagcttgt 1269001 gcgaaaagac gtgtggagca tctgttaatc gatctgtcag gtgttgttgt ggtggatacg 1269061 atggtggcgc accagatctt taaattgatt gaggcgctta atctgatcgg tgtccggtca 1269121 accctgtcag gaatcaggcc tgaaattgcg caaactgctg tacagctggg gattgacttt 1269181 tcgaatatta ctattaaaac caaccttgcc caagcattaa actatcatca ataaaaaaat 1269241 ccgctatctg tgatagcgga ttttttatga tgcgaaacat aaagatacga gaaaggatcc 1269301 cgcgaataat aagaggacga ggcaaaagaa cacccagtcg cgccggttca cgctcaatgt 1269361 cctgtagtat gtccggtttc tgcttcctgt aaatcctttc gattccatcg caagcgctgt 1269421 ccgttccgct tttctgatgg cgcttgccaa tagcggtatg gtatatcgtt ttaacgcact 1269481 gattttatta atgatgccgc tctccgccgc tcctcctctg attttatgag cctgctgaat 1269541 cagctggacc tcatccttta acagcggaag aaagcgaaag cctgcaatga caccgtacgc 1269601 gagctttggt gagagcctgc actgctggac aaggctcagc ataaatagaa tcggatcggt 1269661 tgtaaaaaca aacatcatcg ataaggcgga aaagcataaa atacgaaacc cgagagagat 1269721 gccgacagac acattatcgc tgttaatgga gatagggcct gcttgaaaca aaaaattatc 1269781 cggtgttgtc ggcacttttc caaaaactgc ggctgtccac acgcatccga atgctaaaat 1269841 caaaaacgga atcgtaaaca acaaccattt tttcaatggg attccggccg ccagtaaaac 1269901 gcccgcaacg atgatgatat aaaaacatgc cggagtgtaa gggttgtaaa taaacgacag 1269961 catgacgaca caacaaaaaa ccgccgccgc tttcacagtc ggattaatga gatgtaacgg 1270021 ttgcttcatc acgcacctcc tcttgaaatg ccatccattc atatagaagg ggaagggtga 1270081 gctttgcttt ttgaacaagc cctgtttctt gagaaaacaa ctgcgctgga gatccgtcaa 1270141 aggccaggcc tgtatcgtga agcacaagca cgctgtcagc atacgaagag actagctcca 1270201 tatcgtgtgt aatcataagg acagcagttc cctctgcctt gatacgttga atcatttcca 1270261 tgcattcagc cgccgtgcgg gcatcctggc caaaggttgg ttcgtctaat aataaaacct 1270321 ttacgtcatg catgagcata gtagctacgc tcagtcgccg tttttgccct tggctgatcg 1270381 caaacggatg atgatcagcc aaatgcgcaa gaccaaaacg ctgcagcagg tgttgcgctt 1270441 ttttctcagt ttcagcattt gctttctggc cgaacagaag ctcgtcatac accgtatcgg 1270501 tgacgaattg atgctcaggg ttttgaaaaa caaatcccat ccgtttacgc aattcttttt 1270561 ctttatattt ctgcagcggc tgatcataga gaaggatttt gccgctttgc ggtttcatga 1270621 gactggccag aactgatagg agcgtcgatt ttccagttcc gttcggaccg acaagcgccg 1270681 ttaaagagcc ttcgcgcaac gaaaagctga tgtctttgaa aatcgcctgc tgtcctctcg 1270741 cgaacgaaag gctgctgact tcaagcacac tctccccaga aggggctttc ttctttttga 1270801 catgcccggc aggaataggc tctttgaaca gcatctcttt tgataaagta aacggcatac 1270861 tcagcttttc ctgcagatga cagacctttg gaatggcgat gcccaatttc tttagtgtct 1270921 ccgcttcatg ctgaaataga tttttcgtca ggccatccag tgcctttttg cctgatttgt 1270981 cgagtacgat cgttctctca atccaaggcg cccattcatc aagctggtgc tcaatgacga 1271041 ggaggctgaa acctttttcc cgctgaagat ccttcatcag atgaacgaac tcccgagctg 1271101 agaaagggtc taaaagagag gtcggctcat ctaaaataat aagctcaggc tccatcgcca 1271161 aaatacaggc gagagccact ttctgctttt gtcctcctga aagggttgag atcatttttt 1271221 cttttaaatg ggtaatgcgt aatttttcta atacggcgtt gattttctct gtcatttctt 1271281 cttttggaat ttgcagattt tccagcccga acgctatttc gtcctccacc gtcagcatgc 1271341 agaactgctg atcaggatcc tgaaaaacga ccccggcatg ctgagtaatc gtttcggagg 1271401 tttcagcatc tgtgaccggc ttttgaaata gaaatacatg tccggactga atgccgtcgc 1271461 aagcctccgg atatagaccg tttaaacaaa gggcgagcga gcttttaccg catccgctcg 1271521 gtcctaataa taaaacacat tctccttttt gaagctcaaa cgaaatgtct tgaaaaaccg 1271581 gtttctcgtc ttcttcataa gagaagctga gctgctcaac cgtcagaagc tcatcaaagg 1271641 cttgcatgtt ctgacgcccg cttccgtttc tttttcagtt cctttccgag tgccattccg 1271701 tttaacacac ctgtataagc gagagagtcg ctgacagctt ttccgagaag ccccgccaaa 1271761 agcgcgccgg aaatgaggcg gatcacaagc ataatgagca gataacctgg tgaataggct 1271821 gcatagccag aaacaaagag atcatagata aagctggcta ctgaagaccc cataccggcc 1271881 agcataagga cagggagaga gtatgctttc cagcgtgttg caagaaatac agcctcagcc 1271941 ccgagccctt gaacaatgcc aatgacgatg accatcgggc cagacggatt tcccagcagg 1272001 cactcaacga gagcggcaat gatttcagaa acgagcgccg cacccggttt tcgaatcatg 1272061 tacgcggcga tcacagaaac gataaaccaa atgccgtaaa ttggttcata ggcgattggc 1272121 ccaaacatac ctgcaagtac gtttccgaaa tgtgtaaata ataaataaac aacggcaaat 1272181 acgatactga taacggacat gatgacaatt tcttttactt tccagctttt catgttatcc 1272241 ctgctttctg ttttttcttg atggactgtt agccgaaaga ttcacagtca tggtgatgtg 1272301 gtttgtttgc tgctcagcca tgcggaaaac ggcctccaat gtgctgaata cgtcatgcgc 1272361 atccccgtca agctcgctcg cgtaatggac accctgtacg aaagtgcctt gggcttttgc 1272421 aatgtcgaca gcctccataa tcaatcccat ataatccggc tcattcattg gataaagggc 1272481 aaattggcac ggcgcttccg ccttcaagcc tcggacagca tcttcattga cacgcttatc 1272541 acctttggaa agatatgtat ccccctgtgt gtcacccggg catccaatgg aaaacgtgcc 1272601 gttcatgacg atgtgttgtt cgctgtttgc tgcatgaagg taaatggctt ttgcagcatc 1272661 gaatacatga tcaatcgatc cgcgtaacac cgtgctgata tggtcggttt tcgtccaaac 1272721 cttggatgta tctgtttttt tcagcgcaga cttgatcaca ctgataaaat catccgtcat 1272781 cggatataaa gagaagcgaa aaccggcgat tctgcttgta ccgcaaatat gctccatttc 1272841 tccgacctcc tgtttttttg gtaaaataaa aaactgcata tcctaaggga atatgcagtc 1272901 atagatcgat taagcgcaca aaaaaataca ccattcggtc aacctgcact tccccacgct 1272961 ggtattatcc agatcgggtc ataagggatc aaagcgcgtt tcttccgcgc tttatctcag 1273021 ccaaaacagc acccctagtg ctttccgtat acaatttttt attttgacat cataatagat 1273081 gataagaatc attttgtaaa caacgaaatc atttttttca tatagggacg ggagaggatg 1273141 gtcaaatttg gaaaaaggac acatattaat tgtggaagat gaagaaaaaa tcgccagggt 1273201 tcttcagctt gaattggaat atgaaggata cagcgtcacg atcaaacaca atggcacaga 1273261 aggtcttgat gcggcagcgg aaggcgggta ttccttggtg cttcttgatg tcatgcttcc 1273321 ggggcttagc ggactggaag tgctgcgccg cttgagaaaa acggattcgc agacaccggt 1273381 catattatta acggcgcgag acagtattcc tgataaggta acaggtctgg acatcggtgc 1273441 aaatgactat gtcaccaagc cgtttgaaat cgaggaattg cttgcgagaa tcagggcggc 1273501 gctgcggcaa aatggaacaa aaactgaaga tatcggcacc tttcttacat atgacgattt 1273561 gcgggtgaac gaaaaaaccc gtgaagtgag acgcggagac aaagaggtgg aattaacgcc 1273621 gcgggaattt gatctgctcg tctatatgct aaagcatccg cagcaagtgc tgacacggga 1273681 gcaaattcta agctcagtat ggggatttga ttatatcggt gatacaaatg tcgtggacgt 1273741 ctacataaga tacatcagaa aaaaactgga ctatccttac gaaaaacagc tgatccatac 1273801 gattcgcggg gtcggctatg ccattaaggg gtaaacgatg aagctgaaga ccaagattca 1273861 tctatacact tcgatatcac tgttgatttt attaattttg gttcataccg cagtatatct 1273921 cattttttcg tctgcgctga catcaaagga tgcggcccgg cttgctgatg agacggataa 1273981 cattgccgaa gcgctgcgtg ccgctgaaac agaaggagtg gctttgcagg atatgctgca 1274041 ggcctatctt ccggcaaatg gcatggtgcg tgtagtgaat ggtgatcaaa aagccgttat 1274101 gacgatcaca aaagaaaaag cctataaaga ttttcctctc tcttttcata gcggcgaaac 1274161 ggcagatgtg aggaaacctg acggcaagct gtttgccgag gctgctgttc cggtgatttg 1274221 gaccgatgga caagtcgtgt ctcttcagct ggttgaaaga ctggagaaca cagaagagag 1274281 tctgtttctg ctgaaaatca tcttaatcgc tgcaagtgct gctgtctgca ttgcttcttt 1274341 ttttgcaggc agcttgctag cccgccgaat catcaatccg atcagacgat taatgatcac 1274401 aatgaaagac atacagcgag acaaagaatt taaaacgatt tctttagaag gacagtccaa 1274461 cgatgaattg tatcaaatgg ggctgacatt taatgaaatg gcaatgatgc tgaaggagca 1274521 ctatgataaa cagcagcaat ttgttcaaga tgcttcacac gaattgaaaa ccccgctcac 1274581 tattatagaa agctacagca gcctgatgaa gcggtggggt gcaaaaaagc cggaggtgct 1274641 tgaggagtcg atagaagcca ttcactcaga agcggtgcat atgaaaaaac tgaccaatca 1274701 gcttttggcg ctggccaaaa gccatcaagg actcgaggtt gatctgaaaa caatcgatct 1274761 gattaaagcg gcgcgcgcgg ttatgcaaac gctccagtcc gtttatcagc gtgacatatt 1274821 gcttgaaaca gataaagaga gcctgcttgt aaaggcagat gaagaacgca tcaagcagct 1274881 gttgaccatt ttgcttgata atgcaataaa gtatagtgaa aagcctattg agatgtcagc 1274941 cggaacgagg aatggacggc catttctatc agtgagggat gaaggcatcg gaatacctga 1275001 ggagcatatc ccgcatttgt tcgaacggtt ctaccgggca gatgaggcac gaaacagaaa 1275061 aacaggcgga acaggtttag gcctttccat tgccaagcaa atcgctgatg agcatggcat 1275121 tgagctgtct gtcaaaagca agccgggaca aggaacagct gtcaccatgc aattcagcga 1275181 acagaatggg ggaggccgat gactaaaaca ataaaaacag tatcttttgc tgcagcagcc 1275241 attttagttg tcatcatctg tacgtttctc atcattcggc aaacccatga gaacgtattg 1275301 tcaaaggaga ctgtcgtaaa aaaagtcgaa gcctcttatg aaggcaaggt cacgaaagca 1275361 acacaatcaa aggataaaaa aacatatgat ataacccttg aaaatccaaa gggaacttac 1275421 tttgtaaaag cagacgcaat atcggctgac attctttcaa tgaatagagt aaaagcagtg 1275481 aatccatctg ccatgacaga aaaagaagcc gagcatctcg cgcttgagcg ggtgccggga 1275541 acggtcaaaa aacaaacacg gcaaagtcaa gttgccactt ataccataca aaaagaagac 1275601 gggaaaacat acgaagtgaa ggtagacatg caggcaaaaa cagtcttgtc tgccgatcaa 1275661 atcagcagca aagatcaaca aaaaacgccg attacgaaaa aagaagccaa aacaattgca 1275721 gagcgaaaaa cgggcggaac agcggatgac gcagatctcg aagaaagtga gggcactctc 1275781 atctttgaag tagacgttga tcttcctgat aataaggaag cgacagtgaa aatcaatgcc 1275841 tacacaggaa aggtagctaa cattgtgtat gaagactgac ggtttctcat caaattctca 1275901 tcttgctctc gttttccttt catgttgagt atgtaaactg tactcataca aaacaaagga 1275961 gggctcacaa atgctcaaga aaaaatggat ggtcggtctt ttagcagggt gcctagcggc 1276021 cggaggattc agctacaacg cgtttgccac agaaaacaat gaaaacagac aggcttcttc 1276081 taagacggat gcactcactg aacaagaagc agaagcaatt gctaaaacag ttgttgacgg 1276141 cacagtagaa gacattgaca gagaccttta caacggcaaa gaagtctatg aagtggagat 1276201 tgaaaaagaa ggtgaagact acgacgttta tgtagatatt catacaaaac aagcgcttaa 1276261 tgacccgtta aaggagaaag cagaacaagt cgccataacc aaagaagaag ctgaagaaat 1276321 tgctttaaag caaacaggtg gaaccgtaac agaaagtaag cttgacgaag atgacggtgc 1276381 ttacatctat gaaatggaaa tccaaacgaa gcaaggaact gagacagaat ttgaaatttc 1276441 cgcaaaagat ggacgcatta tcaaacagga gatagatgac taatcaaaac ccccgctgca 1276501 gcgggggttt ttcatgataa gaaaccttct tttggacaat ctaagtagaa aaggaggcga 1276561 aacgcatgga aaagaaagag gagcaataca tcaatcaggc tgaatatgtc cctcatccga 1276621 cgaaggaagg agagtatgcc ttatttcttc atgaaacgta tcatttgctt tctgaagatg 1276681 acgagacaca aacaacagaa taagggctta ggcccttgtt ttgttccgta attgtgatgt 1276741 aagcgcattt attacttttt tgagttgaca tagcttgttt ttttctgtaa tctcagtgtg 1276801 tcaattcaat taggaacttc gttaggtgag gctcctgtat ggagatacgc tgctgcccaa 1276861 aaatgtccaa agacgccaat gggtcaacag aaatcatcga cataaggtga tttttaatgc 1276921 agctggatgc ttgtcctatg ccatacagtg ctaaagctct acgattgaag gcgcccgcac 1276981 gctttttttg ccgtgcttct ttcaccttca atcccgaagg ctttttttat gcctttaaaa 1277041 cgaaaccaat caaaggaggt gcggagtatg gattctcccc attcgagtca atctgaagaa 1277101 gtacccatat actatgacag caagacaatt gattacacga tgaggagacg aactgccgca 1277161 ccttctggcg aggccggcac gtctccgtag aggaggtacg agtcccgatg gttcaaaaca 1277221 tgacctatga cgaactcatt ttacgcatca ttattttact gcgagacggg aaaatcaggg 1277281 attttagaag tgttattgat gagcttcagc cctatgacat ggcatttatt tttaaagaaa 1277341 tgccggaaaa acatcgcgcc cgctatttat cttatttaac tgtagacgat atcactgata 1277401 tgatcgggga gctggaacgc gaatttcagc ttgtcgtctt aaataaagtc ggaaaaacaa 1277461 aagcaacact ggcgatgaac aaaatggaca acgatgacct cgctcaattg cttgaagaaa 1277521 tggacgaaga actgaaggaa cagcttttat ccagcatgga agcgtcagaa tcaaaagctg 1277581 tacagctctt gatgaattac ccggctgatt cagcgggacg catgatgaca aaccggtatg 1277641 tgtggatccc tcagcattac acggtaaaag acgcggtcgt caaactgaaa agcttcgctg 1277701 aaatagctga atcgatcaac tacttatatg ttattaatga aagcaaacag ctggttgggg 1277761 ttctttccta ccgcgatttg attctgggtg aacctgaaga aaaggtgcag gatttaatgt 1277821 ttacccgcgt catatcagca gatgctcttc aggaccagga agaagttgcc cgcctgatag 1277881 aacgttacga ttttttggca ataccggttg tagaagaaaa caacgtgctt gtcggcattg 1277941 tgacggttga tgatattatc gacgttgtta ttcgggaagc tgatgaggat tacgaaaaat 1278001 ttgccgcttc cggtaaagac atcacctttg acacaaaagc ttacgtggcg gcataccggc 1278061 gtctgccatg gctgatttta ctcttattta tcggactgat ttcaggaagc attatcagct 1278121 attttgaaga cgcgctgaag caggttgtcg cgcttgcgtt tttcatgccg atggtgtcag 1278181 ggatgacagg aaatacggga acacaatctc ttgcggttgt catcagaggt ttgtctaaag 1278241 aagaaatgaa caaaaaaacg attgtgcgcc tgatcttccg ggagttcaga acaagcattt 1278301 ttatcggagc ggtttgttct gtgctgattg cgattgtttc tatcatatgg caggggaatg 1278361 cgcttttggg atttgttgtc gcctcttcac tgttcttaac cttaatcatc ggcacgatgt 1278421 caggaacgat tatccctatt attttgcaca aactgaaagt agacccggcg attgcttctg 1278481 gaccgctgat tacaacgtta aacgatattt tatctttatt aatctacttt ggcattgcca 1278541 ctgcattcat tcactcatta taaacgtaaa aagtccgtct caactgcgag ccggactttt 1278601 attatttaac ggtttttgta ccgaaagtga gcattaagct gcccctccag catttttttc 1278661 cgcacttgcg gatcgttttt taacatctgt tcttttttgc gcatatcctt taaaatctct 1278721 gccgtctgta cgccgtcttc acgcttattg gcgatatcca tcagccgctc cacatcggca 1278781 aaggagtatt ttcttgtccc ccttgaagaa cgctgcgggt aaatgagctt tcgttcctca 1278841 taatacctga tctgtcttac ggacaatcct gtcaattcac tcacaattcc gattgaaatc 1278901 acttttttgt ctttataaga atgatcttct gtggtcattt ttccacccct ggatgtcttt 1278961 tgataatagt atataaaaaa caaagagaaa aaacctgacg cttgtcatat tttctaacat 1279021 caaatagaag atttttgaaa aaatacggaa gaaaaattaa caagaataat gcgtaacacc 1279081 caagcgcgtt ttatccttta tgtaacgaat caaacgagga ggaaggataa tcatggagga 1279141 agaaaaagca gtctcactgg caaaagaaat tatagagttg gatatcaagc gtgatgaaat 1279201 gctggagacg tttatgcagc ttgccggaga acaggctttt caattattaa gatcggttca 1279261 aaacggacaa taccgaaaat cttcgtaaac ataaattctt tacattagat tcataccacg 1279321 ttcatttaaa aagagtatct tttgtatagg atacctcaaa atgaaggagg acgctatgag 1279381 taatttattg aaatccgctt tagaaaaaga acgacgccat tattctgaaa aactctatca 1279441 gataggggtt tataataaag aggtcatgaa caaaatgacg atttctgagc ttcggaaaga 1279501 atacgcttat ttctttcgaa gcattacaaa tcataaaaat tatccttata caagataatg 1279561 tataaggatt tttttgcttt tagaaggaat ttctcgaatt atagcgaata cgtatagtaa 1279621 gggactgaac tcttattata tgtaagggtt ttcattattt ttttataaaa atcctatata 1279681 cgaggtagat atgatgagat tatcgtttaa cgaagaagaa gttgagcgtg cgatgaattt 1279741 gtacagagtt tttgcaaggg ctttcaaaag tgtgtccgaa catagtatcc gtgatagcaa 1279801 agagcacggt tttaatccca ctgaatttgc tgtactggaa ctcctgtaca caagaggccc 1279861 gcaaaaatta cagcaaattg ggtcgagact tctgcttgta agcggaaacg tcacatatgt 1279921 tattgacaaa ctagaaagaa acgggttttt agtaagggag caggacccga aagataaacg 1279981 ctctgtttac gcacatttaa ctgacaaggg aaatgagtat ttggataaaa tttatccgat 1280041 tcatgcactg cgtattgcga gagcgttttc aggtctttcg cctgatgaac aggaccagct 1280101 gatcgtcctg ctcaagaaag caggcataca cagccagcat ttgctgtttc gttaactatt 1280161 ctacactctc tatttcagga gagtgttttt ttgtttccat atgattcttt ttaaaacatc 1280221 tttaatcttc ctatcagaca tttcgccaag gtatccattg acgtgttttt tatactcctt 1280281 catctgttcg ttcgattgaa aaaatgccgc gatatactct tctgctttct gcatgtccca 1280341 gtttctcata tctgtgacga gtttcctttc atgtagaagg tttaaattca tttcctcctg 1280401 tcccggcagt gcatgataaa taaataccgg aagccgtttc tgtaagcatt cactgatggt 1280461 cacgcctccg ggtttagtca tgatgcctgt cgcctgttcg tacaaacggt tcatctctgc 1280521 tttgctgtga aggtaaggaa tcgcctcaat caaggggtgg tgtaaacttt tgacatagga 1280581 gtagagcttt tcgtttctgc cgcataatat tttgtataag atctttccgc ctggcgacag 1280641 ttcctgcacc cattttaaaa tcccaccgac ccccatactg ccccctgtga tgatgatggt 1280701 atatggcggg tggtgctgca aggtatctgc tgattccatt tcaaaatttt ggtgaactgg 1280761 aatgccggtc aagtatatgt tgttctgatc gataccctct gatattagct gcttctttac 1280821 ttccgtgctc ggaacaaaat ggtaatcaat gttcttccgt ccccataatt gattcacgaa 1280881 aaaatcagtg tatacattca caaccgtcag attcggatat tcaggcttta gtcggttcag 1280941 cagataagaa ggcagcgcat gtgtgcagaa ggcgatatca ggctgttttt cttggaggat 1281001 gtgcctcatt tgctgtgtga acagccattc gtacatgaaa tagcgtttgt catgctgaaa 1281061 ttctccgcag gcgaggagcc tgtaaatgcc gctgtacgtt ttcgggaaat attgaatcca 1281121 ttttaaataa gccacggagg acaatttttc taaccgccta tacgaatgtg aaaagatatc 1281181 aatcttttca gctgccagcc cttgagactc taattcagcc tgcaatgcat cagccacatg 1281241 atgatggccg gtggaaatgc ttaaaaaagg aaaaatgaga atgtttttca tgacagtcct 1281301 cctaaaaaaa tatggcaact atattttgag gagaacgttc acaaaatata agggtgtttt 1281361 tgatcataag gaaggtgaaa agatgaaaac ttgtttcctt tccatatgga gagtggttga 1281421 tccgatttat ttcttttttt caaggctaag cttgattgac aacgatcaaa aaagcgtttt 1281481 tcgagtcagg ctgacgaagt acaaaggaca tcatgtcgtg cttagcgacg gaacgcatat 1281541 aagaaaaaat gatgtgctcg ttaaaatcca cctgcataac ataaagctga tcagggagct 1281601 gcaaagcatt gagagcgcag tcagaaaggg aatcattatt tatcagaaag tatatcaatc 1281661 gatgccgctt cttcttgact atatcaacaa tcataaaaaa agcgagaaaa tcaaaggaat 1281721 cattgggatt acaatgcttg acaaaggtgt ggaaaggctc ggctttgatg tgatcacccc 1281781 ggtgaaccct ttttacagat gctttaaaaa agtgtctcat gtgccgattt tatatttgac 1281841 ttcaaagcct gtgagcttgc ggcatttacc gaattcatcc tatttgttta tctcaaaaga 1281901 aaagctgcag aaaacctatc aaaaaaaaga ctgatgcctc ggtcagcaca gtcttttttg 1281961 attaaatctg atgaaatgtc acttcagggc ggcttccgac acggatattt acgccggttt 1282021 gtcccaagcc ctcgctgata taaaatggtt tatcgtgatg ataatgaagg cctttaatca 1282081 tgttcattcg cacgagcttt cccattttca ccaaatgata cggttttggc cagtgaattt 1282141 gcccgccgtg aaaatgccct gacagcaggt aatcataatg aacatctttc atatccagaa 1282201 taatatttgg gtcatgtgtt aagacaagat gatagccatt ttccagactt tgataagagc 1282261 cggtgatatt actccgattc gtactgtaat catcaatgcc gataatattg actggtcctg 1282321 cagccgtctc gattcgaaca tgttcatttt gcagcgtgat acagccgttt tcctctaaaa 1282381 ctcgcttcaa tctctgaaag tcctcttctt tcaatacata atcgtggtta ccgaacaccg 1282441 cgtacattcc atatgcaggc tttagctttt gcaaggcgtt caagtaacct gccagtttcg 1282501 gaatattacg tttccgatca agaaaatccc cggtaagagc aatgatgtcc acaggctgat 1282561 cttttgttaa atgatacagc tcctcaggtg agactgaaat gttttccaag tgaagatcag 1282621 ataaatgaag gatatttaat ttttttctgg ctggaaggcc gtctttttgg tcgattgaaa 1282681 tggtgttgac tttcacatct tttgtattgc ggttcgcttt atatagaaat ggcacaaata 1282741 cgagtatggc caatgaaagt aagattgtaa acaaaatata tcccctccct tctatcagta 1282801 tagtaagtga tcaagcccta tggatagcgg gaattaatgg gtagagacag gttgaaaaac 1282861 ggattgtcat atgatgaatg atttggaagg gaaaagggat aataaatttt gacacatgag 1282921 gcagaacatg ccgacggagt cagaataaca aatggatgtg taagcaatgt tacgattgat 1282981 gagacaacaa aaaaaagaaa catattatct ctggatcgca ttatttcttc ttttattgta 1283041 tgtatccccg ctttttattt taaaggaaga tgcccatatc cgggtccacg ataatttaga 1283101 ttccaacatc gcttggtaca aggttctggc cgatagcgga gaaatcgtcg gcaaggttga 1283161 cgctgccatt ccgcaaatca ttaacgggct gccccgggat gcctttggca ccgagtggag 1283221 cggaattgtt tggctccatg ctttcttttc ttccatgacc gcctatgcaa taagccagac 1283281 ggttacaaga gttgtcgctt tttttggaat gtatgtgctg ctgaagaaac atataatccc 1283341 ggaaccaaaa gcggctttca tccgaattgg cgtatcgctt gcatttgcct taacaccgtt 1283401 ctggccttcg ggaatgctga gtacgcttgg gtaccctttg gcactgtggg cttttttaaa 1283461 tatccgaaaa ggggatatct catggagaga gtggctgacg ctgggcttgc tccctctata 1283521 ctcaagcttt gttctaggct tcttcttttt cctggcaggg atggcgtgtt tttggctgta 1283581 tgatgccatt acaaaaagaa gatggaattt gatgttctta ggcagtattg catttatgac 1283641 gagtatctat cttttcgttg aatatcggct tgtctattcg atgctgtttg agcacgcacc 1283701 gatgcatcgt atcgaattta tctcatctag gcatgacgtt tggcattctc ttcgactatc 1283761 cataaaaaac tttgtctatg gccataatca tgtgatgacc gttcataccg ttgtcatcct 1283821 tccgatcctg atggtcgtat ttgctgctct gctgttcaaa cgaaatcgga caaagccaga 1283881 aaatgtttat ctgtttttat gtgtgcttaa ttacgggttg tcattatggt atgcgttttg 1283941 gttcaacaaa atttgggctg ttccaaagca gaaatttgct tttttagcag aatttaattt 1284001 tgcccgtttt cattttcttc ggccgcttgt tatatacgtg agctttgcgc ttgctttata 1284061 tctcatttgg cggatgggga aaggatggaa atggcttgtg tacgccgcag tcgctgcaca 1284121 gctgatggtg ttggcgcctt ttaatgaaga atatacgtat ggtgttcatt acaacgcgcc 1284181 gacattcagg gagttttatg catcagagca attcaaagag attaaggaat atatcggacg 1284241 tccgcaagat tcgtataggg tggcgagcat cggactgcat ccgtctatcg cccaatataa 1284301 cgggttttat acgttagata cgtataacaa tctgtatccg ctctcatata aatatgaatt 1284361 tagaaaaatc atcgaaaaag agctggaaaa aaattctcgg ctgaaacaat actttgatga 1284421 atggggcagc cgctgctacc tttttgtcga tgaactcggt aaacgatatg atttcaaaaa 1284481 gaactcgaag aaaacgatca acaaccttca attaaataca gatgtattta aaaaaatggg 1284541 tggacggtac attttttctt cagttccgat catgaatgct gaacaaaacc atctcgcgct 1284601 cgtaaagacg tttgaccata aagattccgc ctggcgcatt tatttatatg aaacaagata 1284661 aggaggatat cgattgaaac agtcacagcc agtattaacc atcgtcgtcc cgtgtttcaa 1284721 tgaagaggaa gtgtttcaag aaacaagcca tcagctgaca gaggttgtag atgatttaat 1284781 tgaagaaaaa ttaattgctg aagacagtaa aattctgttt gtcgatgatg gcagcaaaga 1284841 ccgcacttgg gctttgattg ctatggagag cataagaaac aagaaggtta ccggcttaaa 1284901 attagcctgc aatgtcggcc accaaaaagc gcttttagcc ggattgcata aagcgaagaa 1284961 taggtcagac tgcgtcattt cgatcgatgc tgatcttcag gacgacatct ctgtgatccg 1285021 ggattttatg ctgaaatatc atgagggctg cgagatcgtt tacggtgtac gccggagcag 1285081 aaaaaccgat acctttttca agcgcacgac cgcgttaggg ttttatcgtc tcatgaataa 1285141 acttgggatt aaattaattt ataatcatgc tgattttcgt ttaatgaata aaaggtccct 1285201 tgaagagctt gagcgttatc cggaagcgaa tctgttttta agaggtattg tccccatgat 1285261 cggctttaaa tcggccgaag ttttgtatga ccgcaaggaa cgctttgccg gcaaaacgaa 1285321 atatccgctg aaaaagatgc tatccttcgc ttttaacggg attacttcat tcagtgtcgc 1285381 accaattcga ttctttacgc ttttagggtt tgttttgttt ttcctcagcg ctgtggcagg 1285441 gattggcgcg tttattcaaa agctgctcgg ccatacgaat gcaggctggg cgtctcttat 1285501 catatccatt tggtttttgg gcgggctgca attgatggga attggaatca tcggagagta 1285561 tattggaacg attttttctg aagtgaaaag acggccgaaa tacgcgattg atattgattt 1285621 gtataatgaa cagctgagcc cgcttcagcg ccaggaaaaa gagcggttag aaaaaaagta 1285681 cagttaaaca cggaaagagc tgacttcatt agtcagctct ttttcttcaa ctgatgcaat 1285741 atagcgctaa gcggttcgtc ttgcgggttg cggtaaaaat caaaaaatgg gcagccctgc 1285801 ttcttaattc gatcgatgac cgtatcaatt gtaaacagag cgggtgttaa agatgattgc 1285861 acctcatgcc agtagagcgg ggctgcaaca gtcccaagct catttcctct cgttgaatag 1285921 ggacagataa tcgtttttcc ttctgcatgc tgcaaataat caagatacaa tttgcagtgt 1285981 ctgtttttaa tcaagcgttc agtggtaaag agctcgggaa atgcattggt gcagtactct 1286041 gcgatcagct gcgtaaattg gcgtgtttct tcatacgtaa atgcctcggg agacaaggga 1286101 atataaagct ggatgccttt gttgccggac agcttcgggt acgatgtgat gccaaaggaa 1286161 tccaacagcc gcttcagttc atttgcggcc tgcacggcca taagaaagtc atctcgcgaa 1286221 ggcgggtcta aatcaatgac aatctcagcc ggacgcctgc ttttaatggt ttgaaaagga 1286281 acgtgaaact ccaaagcaag ctggttgcaa agccatagca atgtagacat atcctcacag 1286341 acaatatgtt catggcttcc atcatagaaa gactgaacaa aatccggcgc atagtccggc 1286401 ttgttttttt ggaaaaatga ttcgctccta gatccatgcg gatagcggat gacggtgaca 1286461 gcccggtttt tcagaaatgg gagcaggtag tcactgactt caatcatata ctgaataaaa 1286521 tcttcttttg tttttttatt cttttcaaat atgattttat ccaggcttgt gaactggagc 1286581 tttgggtgaa ccggtttgga gtgtcgtatg acttgcgcat acgtgcattc ggtccagtcc 1286641 atttggaatt cgaaaccgat aaacgatacc tctcttaatg tgccttggag aattgttaag 1286701 tattgaacag ctgcacaaat cgaaggttca agcgtaaatt cgcctgaggg tgtttgatgt 1286761 ccgtgctgtt ccataatctc gcgtatagcg cttttttcct catcacgcat tccgtgcgag 1286821 acagaggcaa tcggtgtcat tattccgttt tttaacaccg ataccgtcag aaacccgttg 1286881 ttagggttga accctgttat gcaaacataa gcttgtttaa agtttttata tttgagccaa 1286941 tcggacgacc gcttcttttc aagccatttg ctgtttgttt tcttcgctac aattccttct 1287001 ccgtcatatt ttattaccat ctcccagagt tgatcaaaat gatcataaca gggaatggat 1287061 tgaatggttt cttttgcgta aggatctgga gatgcaggaa gctttgctgc ggatatgagt 1287121 tcacgcagcg attttttgcg gtccaaatac gaaagaagcg ttacatcttc tccgcttcgc 1287181 tctaacaaat caaaggcgag aaagcagcac ggccgcgcgt ttgccgattc ctgaatcttg 1287241 tctggccttt tcaaacgccc ccgcacttga aggtgttcaa aatctgcacg acagggattc 1287301 accaaacata cgatttcacc gtcaagtgtc agcggaagct ctttttctag gtgctgaaag 1287361 gcagttttgg cgaattgtgt gatttcaggg aaggtgctgc tgagctccac accatttctg 1287421 ctggttaagg tcacacctga agaatggatg cggagaatac agcggtaccc atcatatttt 1287481 acttcgtaac gccattctgc tccgattggc ggtgacgaag ttaagaccgg ctgcatggta 1287541 aacgccatgc gctatgatgt gccggaggct ttttttctag ttgttttttg ttttttatct 1287601 ccggctcctt tcggttcagc ggcttgtgca ggtgcggcag ccggtgtctc ccggttcggc 1287661 cttctggttc tgtcgatgct ggcttgcaga gcgcttacca ggtcaatgac atcttcacga 1287721 ggtggcgctt tatcaggagt gacagccgtt tctttatttt ctagcttgtc gttgactctt 1287781 tgcagcagcg cctgtcggta cgtgtcttca tatttctcag gctcaaactt agcagtcagt 1287841 tcatctatta atgtgatagc agtttgcagt tccttatcgt ttacattcga ttgatcaggt 1287901 acacctggga cttgagcggc gcttctgacc tcatcgggat aatggataga ctccatgacg 1287961 atacaatttt cataaacgcg gagaatcgcc agctgctgct ttgacctgat tgtcatattg 1288021 gcgataccga tctttccggt tgagcgcagc gcctcacgca gcagggtata ggccttcgtc 1288081 ccattatccc cggggccgac aaagtaggag cggttaaaat aaatcggatc aatttcctga 1288141 agctgaacaa agtcaacaat ctcaactgct ttctcctcat gctcctgttt taagcttttt 1288201 aaatcttcgt ctgtcagcac tacatatttt ccttttacat attcatatcc cttcacaatt 1288261 tcatcaggac taagagtttt ttcgcaattt gtgcaaactt tctcgtattt gattggtgcg 1288321 tgatcctctt tatggaggct gcgcagttta atatctttat cttctgtggc cgcatatagc 1288381 ttgatgggga tgtttactaa tccgaagctg atcgatccct tccacattgt atgcatatcg 1288441 ataaacccct ttttttcttt agtgtgaaga gaaggagtac gattcatgtg tagtaactta 1288501 tgggtgaaaa aaagccggcg ctgttattgc gacggctgtt caataatgaa ttgttcgaat 1288561 tgttccggag gtattggcct gctgaaaaag aagccctgca aatggtcgca gcctttttca 1288621 aaaagaagct gcttttgagc tgcattttcc acaccttcgg caatcacctg caaagacagc 1288681 tgatgcccca tggcaataat agctccggta atttgctctg atttaggatg ggtctgaata 1288741 tcgtcaataa atgatttgtc aatcttcagc ctgtgaatcg ggaagtcctt caaatagcta 1288801 agagagctgt gaccagtacc gaaatcgtca atactgattc tgattcctaa ttctgttagg 1288861 gatgacaaaa cctttttgga gtgattgaga ttgtccattg tcatgctttc cgtcacctcc 1288921 acttcaagaa gctgcggagg aagctggtac ttattaagcg tatccttgat gaggggaatc 1288981 agatctttag attgaaactg tctggcggaa atattaatgg cgacagaaag atcatagcct 1289041 ttgtcatgcc aaatccttgc ctgcttgcat gcttcatcta taatccactt tccgatatca 1289101 ataataagtc ccgtttcttc tgcaacaccg atgaattctc cgggcggacg cagttgcccg 1289161 tctggtgtca caaggcgtat cagtgcttct gctcctgtca ttttttgttt tttcacactg 1289221 aattgcggct gataatgcaa gacaaatcta tcgttttcga ttgcttctct gagtaccatc 1289281 tcttggttaa gcttaacggt ttctttgttg ccgattgaaa aagaatagta tctgtatttg 1289341 cttttgtttc gttctttagc cgcatacatc gccatatcag cctttttcat caattcaagg 1289401 ccatccgtcc cgtcttttgg agatatcgca atcccgatac tgacagatgt gacaagggtg 1289461 tgatcttgaa ttttgaaagg ttttttgaat ttttggataa tttttcttgc taaaacatct 1289521 gcttcgcctg ttcctgtatt ggcgtctgtt aatataataa taaattcatc accgccaaga 1289581 cgggcgataa atccgttatc agggactaca gatgacaggc gtttagctgc aaactgaagc 1289641 aattgatcac cgacattatg ccctaatgca tcgttaatca ctttaaaccg gtttaagtca 1289701 agaaagaata caacagtgtt ataatgcaag gaatgctcgc gattcagcac ctttgttaga 1289761 tgagagatgg catgccttct gttaggtaag tctgtaagcg aatcataatg agccattcta 1289821 tggatttctt tttctgcttt gtactgcttc gtcatgtctt tacaaatgac ataaatgctg 1289881 tctagttcct gattgacctc aacaggtata agcgtaatat ttaagtgaaa ctggcctttt 1289941 tcagtgataa gatcgctatc gctgttcatc gcttgtttat cttttttaac ttgctcaaaa 1290001 aggcgcttaa ccttcagtga tgtgtaattc ctccagtcat gcatgctgaa gccaaatttg 1290061 ctgatcattt cctcaccagc gtgattggaa gatattatgt ctccttctaa tgataaaata 1290121 aaaattgcat caatattgtg gacgattaaa gactgaaatc gctgttcgtt atcctttatg 1290181 cgttcgctct gtttaataaa ctttcgatct gcatgggaac tgaataacaa taacgtttgg 1290241 atacaaaaaa taattaaagt aacaaaaatt gaccaatgaa acgtttgcac ctccatatgg 1290301 cttccgggcg gagccatgtc cttatggaaa gttgccgcaa gcatccctgt gtagtgcatg 1290361 cccgaaatcc caatgcccat tacaattgaa ctgacgcctt tatagaatat aagatgctca 1290421 gaatgttttt ttacggccaa gtcaaagaat atttttaacg agacgaaaga ggctgcaatc 1290481 gcaatgataa ttgaaactgt aaataaaata ggttcgtaaa taatcattac ccgggaaatg 1290541 gcagacattc cgatatagtg catagaagca atagatgcgc caagcacaac tgatccggta 1290601 agcagtctgt aatatgtaag aatgtgccgg ctgacaaaat ataatgacac aaatgatccc 1290661 gaaacagatg cgccaatggc tgccattaaa ggcatgaatt catattccat cggcatttcc 1290721 atatggacgg ccatcatccc tacaaaatgc attgaccaaa taccgaatcc cataataagt 1290781 gagccgccga tcagccaaat tttacttttt aagcctgtat tgatggtgac tttccttgaa 1290841 agttcaaggg aaatatacga ggcggtacag gcaattagaa tagataaaca tatgagagtc 1290901 gtattatatg taacgtgtat ttccaaatgg agattccccc cgtatcgtgt gttccagtct 1290961 tgttgactct ctttattatc ggctgcttaa ccgcagagtt tcagccttca aaacgataga 1291021 aatacgaggg agatctattt ttagttcaac tgaccgtgaa aaatgtgtta aaatcatctt 1291081 gatgttttcc gaaaagagaa aaatgtatga tacataaaca tgaaacaagg gagttggtgg 1291141 ctatcgaaga gctggttatg tcatggattg aagcatttaa aagcttatct tattttggaa 1291201 tatttctagc gctcagcatt gagtttattc cggccgaagt cgtcttgccg cttgcgggct 1291261 attgggtatc taaaggcgat atgacacttg ctggcgttgt tttggcagga tcgcttggag 1291321 gagtggccgg tccgcttacg ctgtattgga taggccggta cggaggaagg ccgtttcttg 1291381 aacgttttgg gaagtatctc tttattaaac ctgaagcgct tgataagtca gataattttt 1291441 tcaaaaaaca tgggggcttt gtcgccttca gcggccgttt cttgcctggt atcaggacat 1291501 tgatttccat accgtgcgga attgcaaaaa tgaatgtttg ggtgttttcg ctttatacat 1291561 tcattgctat gcttccgatt acatttgtat atgtttatct cggtgtgaag ctcggtgaaa 1291621 attggaaggc agtcggctct attcttgatc aatatatgct tccgatcggg atagcgattt 1291681 tggcgctgtt cctgctctac ttactgatga aaaagaggaa gaaacgcacg cactccgaac 1291741 aattatctgt atttttgaaa aataaacgtt gacaaatcac tgcgctgcgc atattattga 1291801 cgtataaaat catatttctt gaaatcccaa aggggagtag cgtccggaat gtattccgga 1291861 aacaaagtcg tcatttcatg gattgtatcc atcggctttg ttggcatgcc tgaattcatg 1291921 tctagcaaga cctttgcctt atgtcggcaa aggtcttttt tgcatggtcc ggccggcata 1291981 agatcggatg aagagaaaga aaacaacttt tttgggaggg tatcatttat ggatgcagca 1292041 ttattattag agtatggttg ggttcttctc gtcttgatcg ggctggaagg gattttagcc 1292101 gccgataacg cgctggttat ggcggtaatg gtaaaacatt tgccggagga aaaaagaaaa 1292161 aaagcgttat tttatggatt ggcaggggct tttgttctgc gatttggctc tttatttgca 1292221 atttctttct tggtcaacgt atggcaggtt caagcgattg gcgcgatcta tttgctgtat 1292281 atctcagcaa gccacttatt gaaaagatat gtatttaaga aagaagacac acataaagag 1292341 acgaagcaaa gcggtttttg gccgactgtt ttaaaagttg aactggcaga tatcgcgttt 1292401 gctgttgatt ccatcttagc agcagtagcg ctggcggtta cacttcctgg gacatcactc 1292461 ccgaagatcg gcggacttga cggaggacaa tttctcgtca ttttggccgg cggtatcatc 1292521 ggactggtga tcatgcggtt tgcggcttcc atgtttgtga agttattaaa ggaacgtcca 1292581 agcctagaaa cagcagcctt tgtgattgtc ggctgggtcg gagtgaagct tgctttatat 1292641 acgcttgccc atcgcgacat agcggttgtt tctgagcact ttatccattc tggaacatgg 1292701 aagctgatat tctggggtgt cttagcagca atcgcggttt gcggctggtt tatgtcaggt 1292761 gggaaaaaac agccggaggg tgcacaaaac gaacaaaaaa acagcacccg tgaacgggcg 1292821 taatctgaaa gactctgctt aaaagcagag tctttttgtg tttgaagcgt tttcataagc 1292881 gaaataaaat aacattttta taacatcttt gttacaaaaa acacgcataa aaccccctta 1292941 attctttaga aaggcacgaa atcatgtata gaacgtcaga atggtttgtc ataattgaga 1293001 cattggaaat caatatttct ttttctcctt tgcgaatccc tatcaaatta gctatcatta 1293061 atgagtagtt atagggagga actgaggtga aaccagtgct tagccttttg tttaaattgg 1293121 gaaaaaagaa gcaaacactt gaaaaagctg ttgagagtat acaaaaaggc aataaagatc 1293181 tgcaaaatga attaatacag caatataagc catttatcgc aaagacggtt tcatccgttt 1293241 gtaaacgata tatagatgaa aaagacgatg agttcagtat tggactgatc gcgtttaatg 1293301 aagctataga aaaatattca cctgaaaaag gaaattctct gctcgcattt gctgagctta 1293361 ttataaaaag aaaagtcatt gattacatta gaaaagaagc cagaagcgca caaaatataa 1293421 atatcgattt acaggaagga gacgatcagg agtcatcaca aagcctgatt gaagccgagc 1293481 tttccattga tgaataccgc cgtcagattg aacaggagca gaggcgggag gaaatcctct 1293541 attttcaaaa gcagctcaag gattatggtt tatcgtttaa agaactgctt gaaaattctc 1293601 caaaacacac ggatgcaagg caaaacgcca taaaggtggc aatgacgctt gttgaacatg 1293661 aagaattggc cgctatcctg tatacaaaga agcagcttcc ggtcaaacag cttgaacagc 1293721 ttgtctctgt aagccgaaaa acgattgaga gaaacagaaa atatattatt gcgatgtgta 1293781 ttatcattac gggtgattat atttatttaa aagattatct taaaggggtg ctgcactcat 1293841 gagaagaggg attatagtag agaaaaataa aaaattcgtc acgttgctga cccctgacgg 1293901 acaattttta aaagccaaaa atgatcgaca cagctatgaa atcggagaag aaatcatgct 1293961 tccgagtgaa acacgcatgg gcagaagggc cagctttttt gattttttta aactgcgccc 1294021 tttcaaaatg gggattttta cgatgactgc tattatgctc tttattttta tagttctccc 1294081 cgttttttct aataataagg cctatgcgta tatgacaatc gatatcaatc caagcgtcga 1294141 aatggcgtta aacagcgatt atgaagtgat tgaactgacg cctctaaacg atgagggaca 1294201 gaaagtcgtg aatgatatag atgattggga gaagactgat tttaaaaagg tgattgacga 1294261 tattataacc gactgcagtg aacacgggta tgtaaaaaaa tcgaaagaaa tattgatttc 1294321 cactgtttat gaaaacacag aagacaatac atataaaaag gctgtgaaaa aacagctgaa 1294381 tgatgtgact gaaaaatata aaacgacata ccgcatggaa tctctcgagt cagatatgca 1294441 aacgagggaa aaagcgaaga aagaaggcgt ctcaacaggc agctacatca aatcaaatga 1294501 aaagaatgac aataaagata taaaagatga ctccagcaaa ccatccgggg aagaggatca 1294561 aaagagtgat gaaaatgagg atgaaaacac cgatcaaact gacacccagg acagcaagca 1294621 aggagataat gaacagctga atgatgcgga ttccggagac cagaaagaag agaaagcgga 1294681 tgaccagatt gatgatagtg acaaagataa aaaaataaag gaatcagatg aaaacacaaa 1294741 taccgaaaaa gatggggacc atgagcaaac cccaatacaa gatcctcaag ataaaggaaa 1294801 tgaaaataac ggcgctgaca agggccaaag ccaatatcac agggactgga acaatggtga 1294861 acaaggcaag aaccgttctt cgtccagaag ggataacgct tcagaccgac gtaatccaaa 1294921 cggctacagc agtgataatc attcagctaa aaatgaagat tcgccgagtg cccccggcga 1294981 ataaagacct gaatttattt agttgtgcca tttaattgtg attgtgcttg ctgtaccagc 1295041 cgctttgtca tttctccgcc tacagagccg ttagcgcgtg cgactgtatc agaaccaagg 1295101 ttcacaccga attcttgagc cacttcgagt ttaaattggt ctagtgcctg ctccacccct 1295161 ggaacaacga gtttatttct gctcgccatc tttttcatct cctttttcga taaagaaatt 1295221 cttaacgcgt atttagtttg aaatatacgg ggtttattta tgctggcaat tgttgtggag 1295281 aaaaataaaa ccccggcctc tgagccgggg tggcgcagac tatagaatgt ctgctgtcat 1295341 tttatgtgcg gttgcctgaa tatggaatgt caaaatggag aggactgtaa tggcgataat 1295401 ctgtctgatt ttaagccatt ggctgtcatt cagttcttca aaacggtgac ggagacgctc 1295461 tgtctcctgt tcggcgatct cctgcagatt tgattctttc atagaaggag tatcttggtg 1295521 atggatggca tcaagcacat atgcgcagct ttcataataa gcaatcgggc tgatgacatc 1295581 atcagatctg tctgagattg tgttaaaggc cacttttaaa atagcccgta tgtgttcaaa 1295641 gtcataaatg gattttaaat cacgtacaat taaaagaata actgcctgtt caattgagta 1295701 ttttttgccc agctcagggt gtccgatcag atctttgata tcacgcttta cccagttttg 1295761 aatcgcggtt gactttaacg aagtcagctc gcataagttg ccaagctcta cgatttcatt 1295821 tgtagacaga ccgtattctt ttttctgttt ttttcgttcg tatcttgtaa gaaattcagg 1295881 aatttctaga tgattggctg ctttttctgc tgacatgttc gctgattgga cgagaatgtc 1295941 gagcgggcta tgttctcctt gtccttttag ggaatagagc agccgcacca tatcggttcg 1296001 agagagttta aaaatgttca ttgttcacct ctttaaacaa tttgacgcgg atataggtct 1296061 atgtataagt tcaaaattca agcgtcagca aattacatta acatcatacg tcgaattcct 1296121 tgcattttca aatggatgtt ttataattta aatatacggg ttcttttgaa cttaaaataa 1296181 cggaggttgt tatggcgaaa agaatttttc tgtttattct aacgaatatt ttggtgctta 1296241 caacaatcgg gatcgttttg tctgttttaa gctctgttac aggagtcggg acgtacttta 1296301 cagctgatgg cggtatcgat ccaatggcgc ttcttgtgtt cagtttagtc gttggatttg 1296361 tcggttcctt tacgtctctt gcgatatcca gatggatggc aaagacgatg atgggcgtca 1296421 gagtgctgaa tccgaaaaaa cactcgctca gctatgagga acagcaattg gttgatcgtg 1296481 ttcacagatt aagccgctct gccggtttaa cgaaaatgcc ggaagtcggg atttaccgtt 1296541 cacctgaagt aaacgcgttt gcgactggac cgtcaaaacg ccgttcactt gtcgcagtat 1296601 cgtcagggct gctggagcag atggatgacg cagcagttga aggtgtgctt gcccacgagg 1296661 tcgcgcatat cacaaatggt gatatggtaa caatgacgct tttacaaggt atcgttaata 1296721 cctttgtcgt ctttttatcg cgtatcgccg cttggatagc aagccgtttt gtcaaagaag 1296781 atctagcgcc gatcgttcat tttattgcaa tgattatttt tcagattgtc ttttcgatac 1296841 ttggcagcct ggttgtgttt gcgtattcac gccatcgtga attccatgct gacaggggag 1296901 gagcggatct tgccggcaag gacaagatga ttcatgcgct gcggacgctt aaaagctatt 1296961 cttcccggat tttggaagac gatcagacag ctgtccaaac gttaaagatt aatggcaaga 1297021 agcgctcttc acttttctct actcatcctg atttagatga gcgaatcaga cggctggaag 1297081 ctaaataata caaacacatt gttcctctga gagaattctc agaggttttt tattttatcc 1297141 attgactaaa atcataaaaa aataagcaag ttaagaaaat gtttcgtaaa agcctttaaa 1297201 aatggaccta atatctttag aataattacc gtacttaaaa agagaggcag aaggatttta 1297261 catgagatta aagtttggaa aattgataca ggccttgtca ccggcccagc tgatcgcatt 1297321 atattatttt cttgcagtta ctgtggccgt tatattgctg agtttgccgg cggcccataa 1297381 accgggggcg gattggacgt ttattgatgc gctttttaca gctgtcagtt cagtcagtgt 1297441 aacggggctg acagttgttg atacagctga tacattcagc acaataggga tttttatatt 1297501 agcatttgtt ctgcaatttg gcggaatcgg aattatgacg ctcggaacgt tcatttggct 1297561 gatcatggga aaacgaatcg ggctgaaaga acggaagctg attatggttg atcaaaacca 1297621 atcccagttt tcaggaattg tcaatctgat gaagcaggta ctgtttctga tcttgtggat 1297681 tgaatttttt ggcgggctga tactcggcac atatttctta acctactatg actcctatca 1297741 ggaagcctat ttacacggat tttttgccag tatcagtgca acgacaaacg gcggatttga 1297801 tattaccggt aattcgatga ttccatttcg ccacgattac tttgtgcagt ttattacaat 1297861 gcttttaatt atatttggag cgattggatt tcccgtgctt gttgaagtaa aggatttcct 1297921 gttttcaaag catcggcgtt atccatttac gctttttaca aagatcacga cgattacgtt 1297981 cggctcactt gtcttgtttg gagccattgg catctttgcc ctggaagcaa accatgcgtt 1298041 cgcaggaaaa tcatggcatg atattttgtt tttgtccctg tttcaatcaa cggcaacccg 1298101 aagcgggggg ctggcaacaa tcgatatcag ccaattatca gattccacac tcttttttat 1298161 ttgtgcgctg atgtttattg gagcgtcgcc aagctcagtc gggggaggca taaggacaac 1298221 gacttttgct ttgaaccttc ttgcgctgtt tcattttgcc cgcggcaata aggccgtaaa 1298281 ggtattcaaa cgggagcttc accctgctga cttgatgaag tcgcttgttg tcacgatgat 1298341 ggcgatcctg ctcgtttttg gcgcgacact cattctgacc attacagaaa aacattccct 1298401 gctggagctt ttgtttgaag tgtgctcggc attcggtaca accggcctat cgcttggaat 1298461 tacggcagat ttgagcagtg ttggaaaatg cgtcattatg attgtcatgt ttatcgggcg 1298521 aatcggcatc ttgaccttcc tgtatctgat cggaagaaag gaaattgaag cgaattatca 1298581 ctatccgaag gaaagagtga ttatcggata ggcaaaacac cgcatatttt gcggtgtttt 1298641 ttgattacca aaaaaaagat gtgtgcctcc tgttcagttg gagaacctaa ctccgacagg 1298701 tgcaatttac gctcctgcat cttaaaatgt ctgaaaattg gcgaggagga ttcgtatgaa 1298761 gcgtaaagct gaagtgaatg aagccattaa aaataacaat acacctaccg agagcatgga 1298821 ccccaattca tataagacac aatatcatga cgaccccaat tttagagggg caaaccgcaa 1298881 ttccaaacag ggccagcagg gaggcatgta attgtgaaga aaaaccgtca tagcagagac 1298941 atgcaaaatc ataaaaagcc tatgaataaa aaggtgctgg aggaagaatt ctcaagtgaa 1299001 ctcggggatt acaatgccgg aaagatcatc gaaacgctgg aagtcaccaa gcctgaaaag 1299061 aaaaaagaaa aaaacaaaaa acaacaataa aaaagacctc ttaggcggcg tcccgcttaa 1299121 gaggtgcttt ttctatttta aataagcatt tttgcccgtt cctctgacaa attgcaataa 1299181 gcttgtcatc ctcagctcaa tgaatggctg agcgactgtc ttaacaaagt tgctggagag 1299241 gactgatgtc agggctgctg ttaaaagcaa gaggatcact aagctttgat agtcagtaag 1299301 ccaatcctca agcccgacct gccgtaatgt cttaataata aacccgtgaa gcagatacac 1299361 gtaaaatgtc cgggttcccc atttggtaaa gaaataccgt ttttgcggaa cgagcgctaa 1299421 aaagctgaag gttgccccaa aggcgagtac ataccagccg attcgggata gtccgcttac 1299481 cagggtaacg tctccaaatg aagaatacgg ttttgaacca aacagaaaag aatagtcaaa 1299541 atcgatgccc cagcagatga cgaatactgc ggcaagcact ccgagcgcaa tttgtttgcc 1299601 gcgttttgat ctcaataaat caaaatgatg tttatttaaa taaaaaccga caaggaacat 1299661 cggtaagaat acgaatgtcc gtgacaagct cagcgtgctg ctgacaaagt ccagataacc 1299721 gatcagcacg gcgattccgc agctgacaaa cagcgcccac tgctttgaaa gctttgaaaa 1299781 aggatatagg agcaggttcc aaaagaataa gcttacaaga aaccataacg accattgcgg 1299841 atcaatcggg ttcacatttg ccatgctttc atcttgcata atgtaataaa agacggaata 1299901 aataatttgg aaaatcaaat acggaataat cagcttgacc gccagctttt ttacatatcc 1299961 cgcccgttta aagcctttcg cgaaataacc ggatacaaga ataaatgcag gcatatggaa 1300021 tgtgtaaatg aacttgtaga ggtagagcat aaaatgatta tcattaataa aggaacgaag 1300081 gatatgaccg aatacaacaa ggaatatcaa taaaaatttt gcgttatcga aataactgtc 1300141 ccgcgattta ctcatagcat caccttctct ttcatcagtc actaagagat tattccctgc 1300201 tggtacatat tttaaaataa aagatgaaaa aggaatctaa aaaaatgctg attgttaggt 1300261 cgatgtaaag tgacggtaag gatcgtagaa aatgtcttcg taatgtaatg acgctgaaat 1300321 tttctgaaat ttatagggca aatgaaggaa gttcccgcat tttgtagaaa tattgaggga 1300381 taggttttga agaaggagtg tacatgcatg gaaactcttg gtgtccagac aaactcggag 1300441 ctgcgagagg aactgaatcg cctcaaagaa gaaaacgcgc gactgaaaaa ggaattgaat 1300501 cagcatcaag tgattgtcaa caatacgctc gatgctattt ttatttgtga taacgaaatg 1300561 cggattgttc aggcaaatga agcaacagaa aggatgcttc aagttgactc ggaagatttg 1300621 aaaaagcgtt ctgttttgga ttttttgttt tcaatcccaa aggatgaact gaatctttcc 1300681 gtaaagaagt tttttaaaaa aggctttctg tggaaggagg ttccgatcag gcttgattgc 1300741 ggggcaacaa aatacataga gtttctggcc aaaagaggta ttggtgagga tttctttttt 1300801 gttgtcatga gggacatatc ttctaagaag attctggagc gggaattctc tatgaatgaa 1300861 cagcttttta aggacttgtt tgacagagca gttgacggaa tcgtcctgtt tgataaagat 1300921 ggcggtttta ttgatgcaaa tttgtccttt tgtaaaagct ttgaaatcaa tcataatgag 1300981 ctgtctcatt tatctttgta tgagttcata gacagcggct cacgaaaaga tttcgacaat 1301041 atctggaagg cgctcaaccg caagggaaaa gcgaaggggg agctgcctgt caagcttcgt 1301101 tcaggagttc aaaaactatt tgaattcacg attacatcaa acatcatcag cggtttttat 1301161 atgtccatta tgagggatat cacagagaag cggtctatgg agctgcagct ctttaaaagt 1301221 gaggagcgct tcagagaaat ctttgaaaat gcaatggacg ccatcatcat ctggtcgaat 1301281 gacggaagaa tcgtaaaagc gaatcaatca gcctgtaaaa tttttgagct gccgatgaat 1301341 ttgctgttga aaagaaagct gtgtgatttt ctcgttgact cgcagcagaa atacagcata 1301401 acgaagagga aatacgcaaa atacggagag atcagagaag agctgctgtt tcaaatgggg 1301461 aacggccaat tcaaagagct tgaatttact tcaaaacgga caatccttga aaatcagcat 1301521 ttgacgatct taagaaatgt aagcgacaga aagcggatgg aaaaggagct tcgggaaagc 1301581 gagctgaaat tcagaaaagt gttcaacgga tcaatggacg gcaatgtatt gttcgacaat 1301641 caatacagga tcatcgacgc caacccgtta gcaagccata ttttgggcct gtcacatgaa 1301701 gagatcaaac agcacagcct gttagatatt atttctgctt atgaaataga aaatttggca 1301761 tcaccggcaa ggcagattaa ttttgatgaa atggacaacg aaattccatt tttgctgagc 1301821 agcggtgata acagaaaact cgaattctca tttaaacgga atattattca aaatatgaac 1301881 ttggctatct ttaaagacgt aacagagcga aaagaattgg aggagcgcct gcgcaaatca 1301941 gatacccttc atgttgtcgg cgaactcgca gccggtattg ctcatgaaat cagaaatccg 1302001 atgactgctc ttaaaggctt cattcagctt ctgaaaggga gtgtcgaggg agactacgcc 1302061 ctttacttca acgtgatcac ctcagaacta aagcgcatcg aatccatcat caccgaattc 1302121 ttgattttag ccaagcccca ggccattatg tatgaggaaa aacatgttac ccaaattatg 1302181 agggacacga tagaccttct aaatgcgcaa gccaatctca gcaatgtaca aatgcaactt 1302241 gatttaattg acgacattcc cccgatttac tgtgaaccga atcagctgaa acaggttttt 1302301 atcaatatat taaaaaacgc catcgaagtg atgcctgacg gcggaaatat ttttgtaacg 1302361 ataaaggcat tggatcaaga tcatgttcta atctccttaa aagacgaggg aatcggaatg 1302421 acagaagata aattaaagcg acttggtgaa ccgttttata cgacaaagga acggggaact 1302481 ggacttgggc ttatggtaag ctataaaatt attgaagaac atcaaggcga gattatggta 1302541 gaaagtgaag aagggaaggg caccgttttc catattacgc ttcctgtcag acagaatgct 1302601 gaagaaagaa ggaatgatga atgaactact atacgacagc cgaaacgccg ctcggtgaac 1302661 ttatcattgc cgaagaggag gaccggatca ctcgtctatt tctcagtcag gaagattggg 1302721 tggattggaa agaaacggtt cagaatactg agcataagga aacacctaat cttgcagaag 1302781 cgaaacaaca gcttcaagaa tatttcgcag gcgaaaggaa gacattctcc ctgccgctca 1302841 gccaaaaggg cactcctttt cagcaaaaag tgtggcaagc gctggagagg attccatatg 1302901 gcgaatcccg aagctatgcg gatattgccg ctgctgtcgg cagtccgaaa gcggtgcgcg 1302961 ctgtcgggca ggctaataaa cgtaacgacc tgccgatttt tgtcccgtgc cacagagtga 1303021 tcggcaaaaa cagtgcgtta acaggatacg ccggaagcaa aacggagatc aaagcatttt 1303081 tgctaaacat cgagcgaatc tcctataaag aaaaataaaa catatggcac gttccctttt 1303141 ttcacggccg acatatcatt ttattaagtt aaaaaagttg gtctgatgaa aaaggaggac 1303201 aaagcaattg aagccgagcc gctctgagaa acttgccgtt tttgccgaac tgtttgtgaa 1303261 actgcatatc ttatcaagcg ctcaaaaaga tgaaatcatc aatgttaaca aaaagaaaca 1303321 aaaaaaccgc tgactcggct ccaaatgagc aaagtccagc ggttttttaa tgcacctttt 1303381 ctcctttaaa cagctgttca atctcttctt catagtttcc ggtcataatc cctttttctg 1303441 tgatgattcc tgaaatgaga tcatgaggtg taatgtcgaa agcgggatta aagacaggca 1303501 cattggatgg agcggtccga actccggaaa tctgcctgac ttcctcggga tctcgttcct 1303561 ctatcgggat atcagcgccg catttgacct ttgtatcaaa tgtagataaa ggtgcggcga 1303621 caaaaaacgg aatatcaaag gcgtttgcta aaatagcaag accgtatgtg ccgattttat 1303681 ttgccgtatc accgttcttt gcaattcggt cggctccgac gataacagcg gaaatttgtt 1303741 tttccttcat cgtatgggcg gccatgctgt ctgtgatcag agtgacatca atgcccccct 1303801 gcatcagctc ccaagcagta aggcgtgaac cttgcaggac aggccttgtt tcacaggcat 1303861 aaatgtgtaa tcccaaatct ttttgtttgg ccaagtaaaa cggagctagc gccgttccat 1303921 agcggcttgt cgcgattgag ccggcattgc agatcgtcat gatcctgtcg ccttttttga 1303981 aaagctgcag ggcgttttgg ccgatcaacc ggcacgtttc ctcatcctcg acctgaatct 1304041 gaatggcttc atggacaagg tttgtttttg cttcatttac ggaaatcgcg ttttcgaccg 1304101 aatgactcag tctctcaagc gcccatgaca aattaatggc ggtaggccgt gagctgttta 1304161 aatattgttt gatgtcttcc agtctgcggc ggaattccgt gacattgtct gtttcaatgt 1304221 ctttggcagc aagcgccagt ccgaaggcag ctgtaatgcc gatcgccgga gcgcccctta 1304281 ctttgagcgt gacaatcgca tcaaatacat cctctttcgt cgtcagctcc aaatattccg 1304341 tctcatcagg aagcttttgc tgatttaaaa tggtaatagc tgtttctttc cattcaacag 1304401 aacgtggaac agcaaatgaa tgggtcatga atagatcatt cctttacaag taacttaaat 1304461 aattcaataa catctgttat cgttttgaat tccgaacgtt tttcgataaa ggctgtgccg 1304521 gtttcgagcg ccaagcgttt tctgccgatt cgtttatcaa acggcacgat cgtatccagg 1304581 tcagctacat gggcaaggcc gatcgtgcgt cgtatcagct cacagcccgc aaatccgatt 1304641 gcttcttcaa aaatatggct gagcgtatca gtgaggtaac cgtcgatgtt ggcgtaaaca 1304701 tccagactgt ccttctgcca ggcttcacta aacgtctctt caaacgtttc ccagacctgg 1304761 ttgacatgtt catataacgg ctctctgtca gccccgtcac ggctgagtgc gttcaaaaat 1304821 aagttggcga taaattgccc tacatcaaag ccgatcggtc cgtaaaaagc aaactcagga 1304881 tcaatcacct ttgtttcgtg ctcacttgcg aaaatgcttc ctgtatgcaa atcaccatga 1304941 atcaacgttt ctgcagacgt taaaaatgac tttttcagct tagcggcttc gattttaacg 1305001 ctgtcattat tccaaagctt ttcgacaaaa ggacgaagct cttcttcaaa atcatttgtg 1305061 tcatggtcga agaaaggatc tgtaaaaaca agtctttccg taatgtcgca tagctctgga 1305121 tttgtaaact gtttaacaag ctgttttttc accttaggtt caagcgcgta atctgatgag 1305181 tagaaaagtg tttttcctaa aaattcaccg atgtgctgcg acagatgagg atagttttca 1305241 ccctcaatga gtccttttct tgcgatcttg aggtgagaga gatcctccat gacggtaacc 1305301 gccatttccg tatcagaata aaacactctt ggaaccaggt gaggcacatg ctcgccctga 1305361 cggatgagag cgctgctttc gattcttgca cggtcgattg tcagcggcca gctttctccc 1305421 accacttttg catacggaac cgcctgttta atgatcaatg ctctgtcatg ttcttgatca 1305481 taaatatgaa aaacgtaatt taagttgccg tctccgatct cctggcatgt cagcgtgctt 1305541 ttgcttggaa ataggccaag cttcaccgcc aacgccacag cggagctttc atttaacgtt 1305601 tcgtataaag gtgtttttgt gactcccatc atcataacct ccaattatgt aattaattaa 1305661 tatgtggccg taaaaaagcc tccttctcag agagaaggag gcttaacatc tatgtccgcc 1305721 tctcttatct ctcagatcag atctgaatgg aattagcacc gtgccttaag agaccagcgt 1305781 ctcggcgcga aaaaaatgcg ccccatttca caatggaatt acggtcggtt gcttttgggg 1305841 tcaaaaggcc aaatccctcg cccaactctc gataagagaa tatattcact tgtttgacaa 1305901 ttctaattta tcagttgatg aacatggtaa caggtaattt agttagttgt caatatattt 1305961 tttaatataa atcttttctg atatcatcga aaacaggaat gctctcccga acttctgcgc 1306021 tttcttgaag gtcgatttcc gctcggacta tgccttcttc ccggccgcct tcagcaagta 1306081 cacgtcccca tggatcaata atcaggctat gtcctgcaaa ttcattatcc ggatttgaac 1306141 cggtacaatt gcaggctgcg acaaagcatt ggttttcaat ggcccgcgca ataagcaggc 1306201 ttttccaatg atcaaggcgg ggaagaggcc attccgcaga aataaacagc acgttggcgc 1306261 cttttgtcgt atgttttctg atccattccg gaaaacggat atcgtaacag atcaatccag 1306321 agcttttgac gccgtcaagc tcaaagtatc cgtcttcgga accggctgat aaatacagat 1306381 gctcatccat cagctgaaaa agatgggctt ttctgtactc tttaatgatt tgcccttcct 1306441 tatccgcgat gtacattgta ttataaacat cagaattctt cctgacagcg accgatccgg 1306501 cgacaatatg aacaccatgt ttttttgccg ttttcttcag ccagctctga gcggagcggc 1306561 cgtcttcgtc agcgagttca tcaagattgg ccagatcata tccggtcgtc cataattcag 1306621 gcagaacaag aacatcagca tgtttgcttt ctttttcgat gaaaaattca gcctttttta 1306681 tattttccga aggttttccg tatgaaatat caaattgaag acaagatatc gtccatttca 1306741 tctttttaac accccaaatt tttctttact tttttcattt aaccatatat gatgatggac 1306801 tatcatttca agattttttt agaaggtgag aatagatgaa atttgaacag tctcatgtat 1306861 tgaaggaatt gcctaaacaa ttcttcgctt ctctggtgca gaaagtgaac cgaaagcttg 1306921 cagaaggaca tgacgttatc aatctgggac agggaaatcc agatcagccg actcctgagc 1306981 atattgttga ggagatgaaa cgagctgtcg ctgatcctga gaatcataaa tattcgtctt 1307041 ttcgcggctc ataccgtctg aagtcagcgg ctgctgcatt ttacaaaaga gaatacggca 1307101 ttgatctgga tccggaaacc gaagtcgctg tattattcgg cggaaaagcc ggtctagtcg 1307161 agctcccgca atgcttgttg aatcccggtg atacgatttt agttcccgat ccgggttatc 1307221 ctgattactg gtcgggtgtc acacttgcaa aagcaaagat ggaaatgatg ccgctcgtaa 1307281 aggacagagc gtttctccct gattacagca gcataaccgc tgaaataagg gaacaggcga 1307341 aattgatgta tttgaattat ccgaataatc cgactggagc tgttgctact tccgagttct 1307401 ttgaagatac cgtgcgtttt gcggctgaaa acggaatctg cgtcgttcac gattttgctt 1307461 acggcgctgt aggatttgac ggctgcaagc ctttaagctt tttgcagact gaaggtgcga 1307521 aggatatcgg aattgaaatt tacacgctgt caaaaacgta taatatggca ggatggcggg 1307581 ttggctttgc cgtcggaaac gcttcggtca ttgaagcgat caatctttat caagaccata 1307641 tgtttgtcag tcttttcaga gcgactcagg aggctgcagc agaggcactg ttagccgatc 1307701 agacgtgtgt ggcagagcaa aatgccaggt atgagagcag gagaaacgct tggatcacgg 1307761 catgccggga aatcggctgg gatgtaacag ctcccgcagg ttcttttttt gcatggctgc 1307821 ctgtgcctga aggctatact tctgagcagt tctcagatct tttgctggaa aaagcgaatg 1307881 tggcagttgc ggctggaaac ggcttcggtg aatatggcga gggctacgtc agagtcggac 1307941 ttttaacaag tgaagaaaga cttaaggaag ccgcttatcg aattggcaaa ctgaacctgt 1308001 ttacccaaaa aagcattgac aagaccttat aacgatggga taattcaaaa taatttataa 1308061 aatctatatt ttcttatcaa gagcaggcag agggacgagc ccgatgaagc ccggcaaccg 1308121 acttataaag cacggtgcta attcttgcag ctagcggctg agagataaga ttcggacgag 1308181 aaacgaaacc tctttagacg cgattgcagt ttgaagaggt tttttgatat ggatgaaaat 1308241 gaaaggagct ctggcatgag tgagttatta gcgacatatc tcctgaccga accgggagcc 1308301 gatacagaga agaaagcaga acaaatcgca acaggattga cagtaggctc ctggactgat 1308361 ctgccccttg taaaacagga gcaaatgcaa aagcacaagg ggcgggtgat aaaagttgag 1308421 gagagagagg gaactgctgc atcagaaaaa caagcggtca tcacaattgc ctatcctgaa 1308481 atcaatttct ctcaggatat tccggctttg ctgacaacag tgtttggcaa gctgtccctg 1308541 gacggaaaaa tcaaattaat cgatcttcac ttctctgaag catttaagcg tgcactgccg 1308601 ggaccgaagt ttggcgtata cggcatccgg aagctgctgg gagagtttga gagaccgctg 1308661 ttaatgagca tatttaaagg cgtaatcgga agggacctga gtgatattaa agaacagctc 1308721 cggcagcagg cgcttggcgg agttgacttg attaaagacg atgaaatttt ctttgagact 1308781 ggtctagcgc cttttgaaac aagaattgca gaaggaaagc aaatattgaa agaaacgtat 1308841 gaacaaaccg gacataaaac gctgtatgcg gtgaatttga ccggacgtac ggctgatctg 1308901 aaagacaaag cgagacgcgc cgccgaattg ggagcggatg cgcttttgtt taatgtcttc 1308961 gcttacggct tggacgttat gcaaggcctt gcagaagatc ctgaaatccc agttccgatt 1309021 atggcgcatc cagcagtgag cggagcgttt acgtcttctc cgttttacgg tttttctcac 1309081 gctcttttac tcggaaaatt aaaccgatat tgcggtgctg acttcagcct ctttccgtct 1309141 ccatatggtt cggttgcgct tccaagagca gatgcactgg cgattcatga agaatgtgtg 1309201 agagaggatg cttttaacca aacatttgct gttccgtcag caggcattca tcccggcatg 1309261 gttccgctat taatgcgtga tttcggcata gaccacatta ttaacgccgg aggaggcgta 1309321 catggacatc cgaacggtgc ccaaggcggg gggcgagcgt tcagagctat tattgatgcg 1309381 gtcctagagg cccagccgat tgatgaaaaa gccgaacaat gcaaggatct taagcttgcg 1309441 ctagataaat ggggaaaggc tgaagccgta tgacgactcg aaaacctttt attatttgtg 1309501 attttgacgg aacaatcacg atgaacgaca acattataaa tatcatgaaa acatttgctc 1309561 ccccagagtg gatggcatta aaagacggcg tactttccaa aacgctgtca atcaaggaag 1309621 gtgtcgggcg gatgttcggc cttctgccca gcagtttaaa agaagagatt acaagttttg 1309681 tattggaaga tgcaaaaatc agggaaggct ttcgggaatt tgtagcattt atcaatgagc 1309741 acgagattcc gttttatgtc ataagcggtg gaatggactt ttttgtatat cctttgcttg 1309801 aaggcattgt ggagaaagac cgcatttatt gcaaccatgc ttcatttgac aatgactata 1309861 tccatattga ctggcctcat tcctgcaagg gcacatgcag caatcaatgc gggtgctgta 1309921 agccgtcggt catccatgaa ctttctgaac cgaaccaata tatcatcatg atcggtgatt 1309981 cggttacaga tgtggaggca gcaaagctgt ctgacctatg ctttgcaagg gattatttat 1310041 taaacgaatg ccgggagcaa aacctcaatc atcttccgta tcaagatttt tatgagatca 1310101 gaaaggaaat tgagaatgta aaggaggtac aggaatggct gcaaaacaag aacgctggcg 1310161 agagctcgct gaagtaaaac gggaattggc agagagagat tggtttccgg cgactagcgg 1310221 caatctgtca attaaggtta cagatgagcc tttaacattt ctcgtcactg caagcggaaa 1310281 agataaacgc aaagagacgg ttgaagattt tctgctggtc gatcaaaacg gagagcctgc 1310341 tgaaagcggg cattctctga aaccgtcagc agaaacgctt ttgcatacac atttgtacaa 1310401 taaaaccaat gccggatgct gcctgcatgt ccatacggta aacaataatg tgatttcaga 1310461 gttatacgga gaccaaaaga aaatcacatt caaaggccag gaaattataa aagcactcgg 1310521 cttgtgggaa gagaacgcag aagtgaccgt tccgattata gaaaatccgg cacatatccc 1310581 gacgctagcg gcactgtttg cggaagagat ttcagaagat tcaggagctg ttctgatccg 1310641 aaatcatggt attacggctt gggggaaaac agcatttgag gcaaaaagag tgcttgaagc 1310701 gtatgaattt ttgttcagct accatttgaa attgaaaaca ctcgagcatc agctggttaa 1310761 ataaaaggag gaattgaaat ggctacaatt cgaattcatg atgaggcaaa tacaacgatt 1310821 gaaaatcaag aggaagtggc aagctttctg gacagtcaag aggttattta tgagcaatgg 1310881 gatatcacga ggcttccgga acatctctca gagaaatatg acctgacaga agaagaaaaa 1310941 cagcaaattc ttgatacctt cgaaactgaa attaaagata tctcaacccg ccgcggctat 1311001 aaagcacagg atgttatttc attgtcagac agcaatccga aacttgatga actgcttgaa 1311061 aactttaaaa gagagcatca ccatacagac gatgaggttc gttttattgt aagcggacac 1311121 ggtatttttg tcattcaagg ccaggacggc acgttttttg atgtccgttt aaaccctgga 1311181 gatttaatct ccgtgcctga gaatatccgc cattacttca cgcttcagga ggaccgcaaa 1311241 gttgtcgcgg tgagaatttt tgtcacaact gaaggctggg ttcctattta tgaaaaagac 1311301 agcgtgaatc aataagcgtg agatagcccc gttcatcgaa cggggctttt tatatttatt 1311361 gcaaacgcca cttttcatat tgtgacagtt cttttttaat cagtgtccaa atcaaaccta 1311421 aaacagctgc atcgtcaatg aatccaagac cgaggattac gtctggaatg atatcgagcg 1311481 gcatgacgat atacaggatt gcggcagtta acagcaaaag tgttttaacc tgtgaacgag 1311541 ggtagtcgcc atttcgccaa tcgcgaagca tctgaaaaaa agtagtgatg tgctggatac 1311601 atttttttcg gtttttcctc tttaaaatcg cttttccgcc tgccgctccg agcattattg 1311661 ctttcttttt cttcattggg catacctcct gcctggcggc gtgtttaaga tattcttcac 1311721 ctgggtattg ttcttctaat cctatcaata tatctattat acctgaaaaa ttaacttatt 1311781 taatgaaaat atgtttacaa ataaagtata atctgtaata atgcacaata acccaatcaa 1311841 acttgtttcc tatttcttag cggcgagggg tgaagtgaat gggcggttct tctgaacaag 1311901 aaagattgtt ggtgtctatt gatgaaaaaa gaaagttaat gatagatgcc gctagaaagc 1311961 agggatttac agggcatgac acgatcaggc acagtcagga gctggattgt ttaataaatg 1312021 aatatcatca gcttatgcaa gaaaacgaac attcccaagg gattcaaggc cttgtaaaga 1312081 aattaggctt gtggccccgc agagatgtta tgccagcata tgatgcaaat aaatagcggc 1312141 ctatcagatg catatataaa gagagagctt ttcggaagcg ctcttttttt ctggaaaaaa 1312201 ttcatatgaa agagggaact aatgaaggaa ctggcgattc tcattaccga aatggtcaat 1312261 caatttcatg atgcttttat ttccttatgc ggaatatttg gcattcattt aactgacaaa 1312321 gaaatgcatt tttgggtgat cggcattttt ggcatattct ttttcggcgt cactcacgct 1312381 gtgtttacat ggctttctaa atggagtatg acagccttgt cctttatcta taccgttaca 1312441 gtcatcattg tcatcgtatt tgcgattgag attcagcaaa aggtgacggg gagagggaat 1312501 atggagtttt tagatgccac ggaaggtata aagggttttt tagtattttt tatgtttttt 1312561 ttgcttttga aaatgctgtt gcgtttcatc aaaatccttt tttctggaag accagcaagc 1312621 aaatcgaatg gcaatgcccg atcacgaaga taaaaaaccc tcctgacatg gtcagggggg 1312681 ctatgatgcg gatacgggga gggtgatcgt cacctctgtg cctcttcgca cttcactttc 1312741 aatatgaata gagcctccgt acatcagcac gatccgttta caaacaacaa ggccgagacc 1312801 ggttcctttt tctttagaag taacaaaggg aaggaagatg tgatccagca tttcctgaga 1312861 aatcccttca ccgttatcca caactttgat tatggctttt ttatctaaag ctcctaggga 1312921 gatcgtcagt ttgcctcctt caggcattga ctcgaggcca ttttttgcta catttaaaat 1312981 cacttgttta atatgatctt ttgtacattt tacgagtaag ggctgctcgg ttagatactg 1313041 taattcgact tcaacattgt atagattgcc ctcagaataa atgatcggca taatttctcc 1313101 gataatgtcc tgaagtgagt tcagctccca tttttcagct gtcggcttgc cgagaacgag 1313161 aaactcactc actatttgat tgatgcgctt tatctcctgt tcgataatgg agaagtaaag 1313221 ctgatcttcc tcacctttat atttcttttg caacagctga ataaagccgc ttatcccggt 1313281 gagggggtta cggatttcat gggctgtgct ggcagcaagc gtcccgatca gctctaattt 1313341 ttgcgcctcg ttttctgagc gctccagctg ggtctgccgc ttcagcaaat aatacagcac 1313401 gagaataaaa aggatattca gcagaacaat aatacatgaa agcggaagca caaggctttt 1313461 cgacagttct tctattgtga ccgggttcgg atagactttc atattccagc tgatatcatc 1313521 cagatatccg ctgacaggtt tctgatcctc tgcatgagag gcttgtccgc tcgcaaaaat 1313581 cattttcccg tcttggttca caacttcaat ataaacatca gggcttagta agttaatgag 1313641 atttttcaaa taatcaattt gaatagctgc gacaagataa tctgtcacat tacgttttga 1313701 gtccaaaaca ggcacacaaa ttgtgaaaat tggctgacca gtaattctgc tcgaataact 1313761 atctgaaatg actgtctttt tagtttcctt tgcttttata aaaaaagatc tgtcggccag 1313821 gtttactttc gtttttaatt cggttgtgct tgcggtgacg tctcctttgg cattgagaaa 1313881 atagagaccg gaaaatctcg gctctgaatc aaaggtcttt tccaaaattg attgcatttt 1313941 ctttatatca accggtctgt cgatggcgat ggacaaggag gtcattctcg ccattgtttc 1314001 tccgattaaa taattgattt tgttgcggtg aaggtttagc aggacacttg cttcttgttt 1314061 atgttctgca gctattgtat ctttttcttt ttcatatacg aaaaagctga tgacgattgc 1314121 cggaatcacg accagtatga tataaagttt gactctcccg caggcgcctt ttagtatttt 1314181 caatttgcat cgctccaaca tacacctgat tagaggtatt atatcattgt ttcttcttct 1314241 ttaataagaa aaaataacca aaaaaattag aaaaagatgt tggcaagctt acattttaaa 1314301 aaagaagaga aatattggaa agatttttat tgacattttg gtctttgttt attaatgttt 1314361 ctctgtaacg gtttctaaaa ggatgattga gacatgacag aaaaatcact gaagttattt 1314421 atcgtgctgt cgcgcgcgta tcggtctatt aacgatcata tgaataagca tattcataag 1314481 catgggctga atccgactga atttgctgtg ctagagcttt tgtaccataa aggcgatcag 1314541 ccgctgcagc agataggaga taaaattctc ttggctagcg ggagcatcac atacgttgta 1314601 gataagctgg agcaaaaaga acttctcatt cggaaagcgt ctcctacaga cagacgagtg 1314661 acatttgcgc aaattactga aaaaggcatc ggtcttttga acgatatttt ccctgatcac 1314721 gctgctgaaa ttgatgaaat gatcagcgta ttaagcgaag aagaggtaga gatgtgcacc 1314781 gaaatgttaa aaagagtagg attaaacgca aaacagtttc ataataagta aaaaaaggaa 1314841 gcctgatatg tcacaaggct tccttttttg ctatttttca tttgtttccg ctgcgcctct 1314901 cggcaaaatg agaacttcaa cccgccggtt tttgcttcgg ccttccgcag ttttattgga 1314961 agccaccggt ttatactcgc cataaccctt ggcgctgaac acttttgcat cgagcttggg 1315021 gttttcaatc aggagcccca taaagtttac cgctctcatg acgcttaaat gccagtttga 1315081 ttggaattca gaatttttaa ttggcatatt atcagtatgt ccgctgataa tgatatttct 1315141 tggcgggtta atcacaagaa gatttgaaat ctcttttgca agcggcacat cttccttacg 1315201 gatggtcgct tttccagaat cgaagaagat gctgtcttta atcgtaatca gaaggccttc 1315261 actagtcatc ttcgtctcca gctgatgttc cagcttttta tctttgatga acttttccac 1315321 ctggctcttc acattttcaa gttcttcttg atcagctgct ttttcttttt ctttcttgtt 1315381 tttctctttc tcttcttttt cctttttcac ttcatcgatg ccgtctgact cgttttcagg 1315441 aggagtgaca ctggagtagt ccagtacacc ggttccgcct gtaaaaactt cattaaatga 1315501 ttttgagagc atttgaaact tagctgcgtc aatcgagctg ctcgcgtaca gcacaataaa 1315561 caatgccagg agaagagtaa ggatgtcggc gtaaggaacg agccatgatt catcaacgtg 1315621 ctcgtcctca tgcttcttct tcttttttct cgccattttg cgcctctcct tgttctgcaa 1315681 atttcaagcg gtccttcgca ggaagataca ttaaaagctt ttgttcgatg actttcggtg 1315741 cttgtccttc taaaacggat aaaacacctt caatcatgac ctcacgcagt tttacttcct 1315801 gttttgattt tcgttttaat ttatttgcga aaggatgcca taacacatac cctgtaaaga 1315861 taccgagaag tgtggcaaca aaggcagcac tgatggcgtg tccaagctca tctgtgttat 1315921 ccatatgaga gagagcggca atcagcccga ttacagcgcc gagtactcca agtgtcggag 1315981 cgtacgttcc tgcttgtgta aaaatagcgg ctcctgcttg gtgcctgtcc tccattgctt 1316041 cgacttcctc tgtcataata tctcttataa attccgcgct ttgcccgtca acagccatgc 1316101 tgagcccgtt tttcaagaaa gcatcatcta catcctcaat gcttgcttct aaagcaagca 1316161 gaccttcgcg gcgtgcaagc tgagcccatt cagagaacat aggaatgagt tcctctattg 1316221 tgagctgttt attttcctta aataacactc gaaacagcgt aggcactttt ttaatttctt 1316281 ttgttgggaa cgcaataacg actgctgaga ttgtcccggc gataataatt aaaatggcag 1316341 cggggtttgc aagggcgctg aaactgacgc ctttcagaac catcccgacg ctcaatgcca 1316401 caaaagcaag aataataccg attaacgaag ttttatccat agttttcacc aaatcctttt 1316461 ttactagctt gtctatggtt aatatcggtt ttggtgcccg gaactttagg gacattgtga 1316521 atttgttcat gaaatattca aggaagaggc atagaaggga gaaataaaca aaaacgggct 1316581 ctccaaaatt gaaaagcccg ggggtctact gaaattagca gcttgcttgc aagctgtcct 1316641 tcagatggta ttcatataat agtagaaata catattcact gtatataaac atgttccatc 1316701 cctccttaaa aaagtgtaaa ggatgaaggg aagtagcgct tcaggagaag ggacggtaat 1316761 ttctaagtca agagtatgaa agtataaaaa aaagcggctt cctaaaagga aaccgctgat 1316821 tgttattttg ctcgcacttt gattttatca tcttctaaaa tcacgtgaaa acttgtgatc 1316881 tcgccattat caagcagcag atcggtcatt tcatcctcaa cccattcttg gatggttctt 1316941 ctaagcggac gtgcaccgaa tgaagggtgg tagcccagct cagcgatttt ttctttcgct 1317001 tcatctgtca cattcaagct aatgccccgt tccgccaatg tttcttcaag ttctccaaga 1317061 agaaggctga cgattttgac aagatgttct ttttccaatg agcggaactc aataatgctg 1317121 tcaaaacggt tgaggaactc aggtttaaag aacatgctca gtgaatcaat taatgtttgt 1317181 tcttcgatga cactgtcatc tgattggaaa ccgactttcg tttgtttctc accagcaccc 1317241 gcattacttg tcatgatgat cacagtgtct ttgaagctta cagttctgcc ttggctgtct 1317301 gtcagacggc catcttccat aatttgcagg aacatatgct gaacgtctgg gtgtgctttt 1317361 tcaatctcat ccagcaacac aatgctgtaa ggattgcggc gcaccttctc agttaattgt 1317421 ccagcttcct catggccgac atatccaggc ggtgaaccga taattttaga tacggcgtgt 1317481 ttctccatgt attcgctcat atcgagtcgg ataatagcgt cttttgtgcc gaataattca 1317541 tctgccagtg ttttagaaag ctctgttttc cctacgccgg taggaccgac gaagaggaag 1317601 gagccgactg gtctgttttt ggattttaat ccggcgcggc ttcgtcttac cgcttttgcc 1317661 actttttgaa cagcggcttc ttgtccgatc acgcgttcat gaagttttgc ttcgagttct 1317721 ttcattttcg tttgttcgtc tgcctgcagt ttgccgacag ggatgcctgt tttttgttca 1317781 acaatttcct gaatgtgctc agcttccaca gtgacagcgg tatgagcgga ggagctgttc 1317841 agttttttct ccaatgcgag ttcttcatca cggagttttg ccgccagttc gtaattttct 1317901 tcttccaggg cttttgtttt ttcggcttca attgcagtta agcgttcagc ggcatcctca 1317961 tcattcagtt catcaattaa caggttggct tttgaacctg cttcatctaa taaatcaatt 1318021 gctttatccg gcaggtgtct gtcctgaatg tagcgggatg ataaagtgac acatgctttg 1318081 attgcttcat cactgaatgt tacgccatgg tacgcctcgt atttgtcttt aatcccttgc 1318141 agaatgagga tagcctgttc aattgaaggc tcctgcacca tgacaggctg aaaacgtctt 1318201 tccagcgcgg catctttttc gatttgacga tattctttca gtgttgtcgc gccaatgact 1318261 tgcagttcgc ctctggctag ggccggtttg agaatgttgc cggcgtccat tgatccttct 1318321 gcagagcctg cgccgacgag aaggtgaatt tcatcaatga acagaatgac attttttcgt 1318381 tccttcagct cagtgatcag ctgtttcatt ctctcctcaa attggcctct gatccctgtg 1318441 tttgcaacaa gagatgcaac atcaagcaag tatagctctt tgttttttag tttgtttgga 1318501 acatcacctt cagcaatttt taaagcgagc ccttcagcga tggcagtttt ccctacaccc 1318561 ggctcaccaa taagaaccgg attgtttttg tttcggcggt ttagaatttc gatcactcgc 1318621 gccacttcat catcacggcc gatgacggga tcaatgagac cggcttttgc accgtttgta 1318681 atattttgag ccagctcatc aagcaaccct tttttttcgc tttgttttgc tgcgctctgt 1318741 tctttcggct ggaatgcctg ttcaaacgga aatccgaaag attgaggacc catactcatt 1318801 gaaggtttac gggtcagttc gttatagcaa gtttcacaaa gaaccatctg tttatgaacg 1318861 gaatttattt gcatgttaag gcgaatcgtc gcctcgtttt gatgacaatg ttgacaacgc 1318921 atttgccaaa acctccttaa taatttgatc atctttgacc aatgaaagtg aataaaaagg 1318981 tctattgggt ttgaccttct ttgactatta gtatacggca aacttaacgg cattcaaacc 1319041 aatatgctca aagcagactg aatatttgac tatctttgac caattgattt ttaaaaaagg 1319101 ccggtttgtt tgaccaactt tgattaatag tatactctga ctatctttga ctttcaagtc 1319161 ttatgcacaa aaatttttga tttgttacaa agtaaaacat gttttcttcg tcttttcaag 1319221 gaacttgtct cataggttat aaaaaggcat atatggacaa aactgcggtt cgttcggagg 1319281 gaagaaatgg aacaatcaaa agggtctgca agtcagcttg cttttgtgta tgtcggcaca 1319341 gtagtcggag ctggatttgc gactgggagg gaaattgttg agttttttct gaagttcggc 1319401 tggttcggtt ttttcggcat tctcgtcagc ggcggaatgt ttacgttact gggggccaag 1319461 ctgatgatca tttcaaagcg aatcaatgcc aagtcatatc aagaaatgaa catatttttg 1319521 ttcggggcga cggctgggcg gattatcaat gtatttatgc tgtttgttct ccttggagtt 1319581 acatctgtta tgctttcagg ggcaggggcg ctttttgagg aacagctggg gatgtccgct 1319641 cagattggga tgctcattac aatcggtctg agtttaattg tgatgactag aggagtaaaa 1319701 ggcattttcg gtgtcaatgt gtttgttgtt cctcttttaa tcatcttttc aatgattgtg 1319761 gtggccgact cttttatatt cagcgaatca cgaaacgcag ctcagtgggt ctggccgcat 1319821 cgctgggatt ggctgttatc agcagtttct tacggggctt taaatttatc gcttgcccaa 1319881 gctgttttgg ttccgctggc gaatgaaatg tcatcggaga aagtgataaa aaaaggcgct 1319941 ttaatcggag gcacgatgct gacgattgtg ctgtccgcga gttttctgtc tttgtcgact 1320001 cttccggatg tatttttgta tgatataccg atggcgcaag tggtttatct ctttgcacga 1320061 tctgtccatt tgatttattt actcattatt ttcggagaag tgttcacatc agttatcggt 1320121 aatctatatg gattagaaaa acaagtgcaa agctttcttc cagtgaaaag caaatatatc 1320181 tttgcagcca ttatgatcac ggcttatatt acgagccaaa tagggtacgg caggcttatt 1320241 tcaacgattt atcccttgtt tggctatgtg agcctggcct tcataggcgc tttgctttgc 1320301 aaaaaagctc ctcggcggcg cagtttataa atatatataa tgaaacgaac cgtcactata 1320361 gagcgataat tgatctagga accggggact gactttttta ttgtcaagaa aaacatcatt 1320421 atggtaagat agcagaagtg aaaaaattga agaaaatccg tgcgatatgc gggagaggtt 1320481 ctagctacac cctctataaa aaactaagga cgagctgtat ccttggatac ggcctttttt 1320541 atgtttttct agagcacctt ccgaaaaaag gtgttttttt gcgtgaatta gctgtagcga 1320601 tgtctctcgc cggcgttttt attgcggaga aggagaggaa tcatgaaaaa agaaaaagca 1320661 attgtcgtat ttagcggcgg tcaagacagc acaacatgct tactgtgggc cttaaaagaa 1320721 ttcgaagaag tcgaaacggt gacttttcat tataatcagc gacattcgca ggaagttgaa 1320781 gtggcaaaat ccattgcgga aaagcttggt gtgaaaaatc atttgcttga tatgtcactt 1320841 ttaaatcagc ttgcaccgaa tgccctgact agaaatgata ttgagataga agtaaaagac 1320901 ggcgaactgc catccacatt cgttccaggc cgcaatttgg tattcttatc ctttgcgtct 1320961 atcctggctt accaaattgg cgcgcgccac attattacag gagtttgcga gacagacttc 1321021 agtggttatc ctgactgccg tgacgaattc gtgaaatctt gcaatgtcac ggtaaatctg 1321081 gcaatggaga agccgtttgt gatccacacg cctctcatgt ggctcaataa ggcggaaacg 1321141 tggaagcttg cagatgagct tggcgcgctg gattttgtga aaaacaacac gctgacatgc 1321201 tataacggca tcatcgcaga cggctgcggc gaatgtccgg catgtcacct tcgttcaaaa 1321261 ggttatgaag aatatatggt gatgaaagga gagcgtgcat aaattgttat ctcaaattta 1321321 tccgcaggcc cagcatcctt attcgtttga actgaataag gacatgcata tctcagccgc 1321381 tcattttatc cctcgggaaa gtgcgggagc gtgcagcagg gttcacgggc atacgtatac 1321441 cgtaaatata accgttgccg gcgacgaact tgacgattca ggctttcttg tcaatttcag 1321501 cgtactcaaa aaactggtgc acggaaacta tgatcacacg ctattaaatg atcatgaaga 1321561 tttttctcag gacgaccggt attcgctgcc gacaactgaa gtcgtggcga aaacgattta 1321621 tgacaacgta caggcttatt tagacacttt ggagaataag ccgacctgtg tacaggtgtt 1321681 tgtccgtgaa acaccgacaa gctactgtgt ctaccgtccg aaaaagggtg gtttgaatgg 1321741 ctaaaggaat tcctgtatta gaaattttcg gcccgacgat tcaaggagaa ggcatggtga 1321801 tcggacagaa aacgatgttc gtccggacag ccggctgcga ttattcctgc agctggtgtg 1321861 actccgcttt cacttgggac gggtctgcta aaaaagatat tcgctggatg acggcggagg 1321921 agatttttgc ggagcttaag gacattgggg gagatgcgtt ttctcatgtg acgatctcag 1321981 gcggcaaccc ggctctgtta aaacagctgg atgcttttat tgaactgctg aaggaaaata 1322041 acatccgtgc agcgcttgaa actcaaggga ccgtttatca ggattggttt acgctgattg 1322101 atgacctgac aatttctcca aaaccgccaa gctcaaaaat ggtaacgaac tttcaaaagc 1322161 ttgaccacat tttaacttca cttcaagaga atgatagaca gcatgctgtc agcttgaagg 1322221 ttgtcatctt taatgatgaa gatctggaat ttgccaaaac tgtgcacaag cggtatccgg 1322281 gaatcccgtt ttatttacaa gtcggaaatg atgacgtgca tacgacagat gatcagtcac 1322341 tgattgcaca tttgcttgga aaatatgaag cgcttgttga taaggtagct gtcgatgcgg 1322401 agctgaatct cgtcagagtg ctcccgcagc tgcacaccct gttatggggc aacaaacgcg 1322461 gagtataata gaaaggaaga tgaacatgac gacaagaaaa gaatcagaat tagaaggtgt 1322521 aacattgcta ggcaatcaag gtacaaatta tttgttcgaa tatgcaccgg acgtgctgga 1322581 atccttccct aataaacatg taaaccgtga ttactttgta aaattcaatt gcccggaatt 1322641 cacatcttta tgtcctaaaa caggccagcc tgactttgcg acaatctaca tcagctacat 1322701 tcctgatgaa aaaatggttg aaagcaaatc attaaagctg tatctattca gcttcagaaa 1322761 ccatggtgac ttccacgagg actgcatgaa tatcatcatg aacgacttga ttgaattaat 1322821 ggacccgcgc tacattgaag tatggggcaa attcacgcca agaggcggaa tttccattga 1322881 tccgtacaca aactacggaa agcctggcac gaagtatgag aaaatggccg aataccgtat 1322941 gatgaaccat gatttgtatc cggagacaat tgataatcgt taattattcc gttgtgtgat 1323001 acggagtgta aaaggaagtg gagtcacagt aaaatccgaa cattcagcgt taattttcag 1323061 cggaaatgtg acctggtcac agcgaagtgt gacccgcact aagctcaata aaagtgggaa 1323121 aagtcacacc tgaaaatggc tctactcatg ggaattgtat taaaaagtgt gacctgaggt 1323181 gcaacctgaa ctgtgacttt tatgcagtga aaaattgata gtacagaagc agattaaggc 1323241 gtacaatttg tacgtctttt cttttttatc cgaaagaaaa aatgcctatc tagagatcat 1323301 aggcattaaa tattattatc aatatcttca tttatttttt ggctaagttt ctgaaccttc 1323361 tctttaacat ttgaaacagc tcttttttga atttcatcaa ttctcctgaa tatagtcgat 1323421 gacacttctt attagaactt cactttcaaa attgaatatc tcatttattt ctgactgttc 1323481 ttcatctgtt aggtgatggt attgaagttg tttagcattt acttcagcag ctacatcaat 1323541 cctaacttag ttgttctggt tgtacaattt catattcacc ttctgcatac tcttgctccg 1323601 cataatagcc tccccattga cagagctcct gcaagatagg tttaagagat tctccaagtt 1323661 cagtggatga atattcaacc ttcggcggta cttgattata catctttctg ctcacaagtc 1323721 cactggcttc aagctctcta agtgtttgaa tcagcatttt ctgagttata tttgggataa 1323781 tgcgctttaa ttcactcgtt ctctttggtc cattcattaa aaagtataat acaaggcctt 1323841 tccattttcc gccaataact tcctttgtca cttcaaaccc acagctaaat tttttcatgt 1323901 ctaaagctct ccattccaca tttattactt tttagttact atatcacaaa aaagtgggta 1323961 cttccgataa tgtgcttact gaaggatact atatcttgta agttgttctt caagtactta 1324021 aaggtactag acataaaata aaattaattc taaaggagtg ttaagtatgg gtaaatttga 1324081 aggtaaaata gcgcttgtaa cgggtggaac aagtgggatt ggtcttgcta cagcacaaaa 1324141 atttgtaaac gaaggtgcat atgtttatat tacgggacgt agacaaaacg aacttgataa 1324201 agctgttaac caaattggca agaacgtaac cggtgttcaa ggtgatattt ctaagcttga 1324261 agacttagac aaactatatg acattataaa gcaggaaaaa ggtaagttgg acattctttt 1324321 tgctaatgca ggcatcggca acttccttcc attaggtgaa attactgaag agcaggttga 1324381 tagaacgttc gacattaacg ttaaaggaac catctttact gttcaaaaag cgttatcact 1324441 attcccggac aaagtaggtt ctattattgt aacgggctct actgctggat caattggcaa 1324501 cccagcgttt agtgtatatg gagcatctaa agcagcatta agagcactag ttcgcaactg 1324561 gattcttgac ctaaaaggta ctgaaatccg tgtaaatgtg gttagtccag gaggtattct 1324621 tacacctgcc tacgatgagc tttttggtga tgcacttgaa gaggtactgg aaaatagcag 1324681 aaatactgtt ccagctggaa aagttgggac acctgaagaa gtagcaaacg ctgtatcttt 1324741 ccttgcttca gacgaaagca gttacttgac gggtgttgaa ttgttcgtag atggcgggct 1324801 agcacaggta taatttcact gcgcagagat tacaaatagt ccccaaaaaa ggttaatggg 1324861 gatttacttg aagaagtcgt ataaaaaagt cgttttcctt aaaggacagg gaattcgact 1324921 tttttatatt tgaatttgat taacgttgta aattcgcatt ttcctggggc tactactaaa 1324981 tgacctgtaa aaaagattac actgtgaata aatgtactta aagtaacggg ggctcttgac 1325041 ttttaataaa aaataatatc cctgtccttg tattctaata cttttaaaaa tatttaaagg 1325101 aatccttatg tcctgaataa ccacatagga aaatatgttg taggttgctt tctttttttg 1325161 tggggcatcc cacacaagct atctcgtgat ctcacacctg aacgtttttt atagactagt 1325221 accgcgacaa gttatattac atatacatac caataaagta gacattaaaa agtgaaagag 1325281 aggatggaaa tgtgtgaaaa ttcttttcct tgagagtcat cccatgtggc tctatggttt 1325341 accgaatggg tttagggaag caggacatac cgtaatgatt tccggtcctg taagtcggga 1325401 aaatataact gaaatgatag acgaatttaa accagattta atagtatcta tgggatggac 1325461 accagagcat tcaagggaaa agcaggcctg gattcgcaac gctactaaaa aggtgaatat 1325521 ccctctcgtt tattgggcaa ctgaagaccc gctgcacact caaaacttta ctatcccgtt 1325581 aattaaaaag atgaaaccgg attttgtttt cacggtcacg ccttctctgt gtaaaactta 1325641 tgaaagcatg gggattaaag cagctcactt agactttgca tttcacgaaa gtatacatca 1325701 ccagattaaa ccattagcga aatacagttg tgatatagca gtggtggcta atgcttaccc 1325761 taattttctt gaagaacatc cggaagtgtt ccgttcgtcc tctttaaaaa cgcttattcg 1325821 tcctcttata cggaagggta ttcgcattga tttttggggg agaaactggg aaaaaatgag 1325881 taaatatata ggaagagaaa ttccccgcaa ttggatccat ggataccttg attatactga 1325941 agcatataaa gtttacagtt cagcaaaaat cattatcggt ttgcaaaact gtgaaagcca 1326001 acttacacaa cgcacctatg agattcttgg ttccgggggg tttttattga catcggatac 1326061 accagcagtt cgaggtaaat tcaaacctgg ccgcgatctc atcgtttctt cctccccaaa 1326121 agaaacattg gaaaaggtta aatactattt aaatcatgat agcgagagaa aaaagattca 1326181 gataaacggt aaaaaggctg taaagaatga ttcctatcgg catagagccg agagaatgct 1326241 tgaggtgcta aaaagcagag gaatcataag aaacttaggg gaaaccattc attatgtaga 1326301 tgttctcaaa gaaaaatacg tgatccatca tgttactccc ggtgaaacat tatcaataat 1326361 tgccagtaag tataatgttt ccctgcagca actcatggag cttaatcatt tcaaatcaga 1326421 tcaaatatat gctggacaaa tcattaagat tagagagaaa ctgtttagaa atattaataa 1326481 caaattattc taaaggagag taatatgaat gaaggggaaa atacctaaaa taagaaatca 1326541 agcgaataaa gtaaaaagaa cgcctcgtta tatggaattt cccgtgacat acgaagtata 1326601 tcatgtggaa tccggcgata cattatggac gattgccaaa tcctttgaaa ttccggtaca 1326661 acaacttatg aatcttaata agctttcttc agatagaatt tatcctggac aaattataaa 1326721 gataagagaa agataatctt tgaggtttcg gaagcgaatc aaattgaaat gacaatcctc 1326781 atttttttat ttgtggggaa cttgatattt ttggggatga aggggttatg agatgtttca 1326841 aatgagctat tactattctg gattaggatg ggactttatt caacacgttg atcaaacgaa 1326901 cggagtatta aatgttgtgt ctcctgattt tttctatatc agaaaagatg gatcattact 1326961 tctccgttca gctaatcccg atgtgattaa agctcttcat agaagaaaat taaaagtagt 1327021 tccttttcta agcaatcatt gggatcagga tttgggacga tttgcattaa tgaaccgagt 1327081 tcttttagct aaacaaattt ctcatgcaat agaagaactg gatttggatg gagttaatat 1327141 cgatatagaa aaccttacag aaaaagatcg gaatctattt acagatttta ttagattagt 1327201 aaggaaaagt attcctagac ataaagaagt atcagttgca gtggcggcaa atccttttgg 1327261 ctggacgaag ggctggcacg gatcatatga ttacgagtat ttagctaaat atgcagatta 1327321 tcttatggtt atggcctatg atgaaagccg ccttgctggg cctactgcaa gtgtaggatg 1327381 ggtggaaaag tccattcaat atgttctgac ccaaaaaatc tctcctcaaa aactagtttt 1327441 aggattgcca ttctatggcc gctgctggat ggaaggccaa tctgcctctc aagccattcc 1327501 cctttacctt gttgttagta aaaaggcata gcgggacaat tatttttgac accaagagtc 1327561 aatctccaaa agctattttt actgtcaatc acgataaaaa ggggccgttg ccttcgggaa 1327621 catatacatt atggtttgaa aatgaacagt cactcagagc aaaaataaaa ctcgctcaaa 1327681 aatataatct gaaaggtctt ggcagctgga gtcttggaca agaagatgcg tcagtctgga 1327741 atacagtgtt taaaaatata taatgattta tagttcagaa caaaattcga agataattgc 1327801 aatgaatctc taaatggaca tactgaaagg agtttattac gagtgcgggt aaaacagtga 1327861 gggcattcca taggcccttc tcccaaaatg ttctacacga ggcattacat tgggcttgaa 1327921 atacacattc aaacttatgt tatagtacgc attttacgga tgtgttgaat ttattctgct 1327981 tccatgattt aatcatacac atgctacttg atagcagggt tatcgcattt cattcagaat 1328041 tgttcaggat cgatatggaa gcgcacgact aactagaact ttaaaagcat acactcatat 1328101 acttcctgaa tggatgctgg tttatctaaa aaacatgatg agaattgatt gtacgcatgg 1328161 tgaagcatga cttgttgata atcgaccata tggtttctcc ttagaaatga gggggttttt 1328221 acataaaaaa gacgagcgaa tccgggggga attccactcg ccgctttcta atgaaaagac 1328281 gggatgctgg atggcagctc gtctgtttta ttataattta acgaacgtat gtttgtaaag 1328341 gtgtcttttc gaatgaattg gttcatataa ccgttaagaa cagattcatt gtaaacattc 1328401 gctaaggtat gctaagatgc atggactata aaggagtgat atgaagtgaa gacattgcgg 1328461 ttaaacaatg taacgttaga aatggctgca tatcaagagg agagcgagcc gaagcgaaaa 1328521 attgcattta ccttaaacgt tacgagtgag acttaccatg atatcgctgt cctgttgtat 1328581 gaaaaaacgt ttaatgtcga ggttccggaa cgcgatcttg ccttccgggg ggaaatgaca 1328641 aattattcaa catcattgac caacctgtac gaaccagggg ccgtcagcga gttctatata 1328701 gaaataacgg aaatagacaa aaacgccgat tcatgatcgg tgttttttat gtaaaaaagc 1328761 tgccggccgg cagcttttga gaaagcgaat ttcatatgta aggtgttaaa ttgtccgtct 1328821 tgcagttttt tgaataaatg tggaaataag gaggttttaa taggagtctc tgatgatctt 1328881 ataattttta tgattaacaa ctgtcaatga atctaactca agatcccgat agttatccat 1328941 gatcgtcaca tcaacgataa cagaattctc atttactttt tcaacaacac cggttaatcc 1329001 gtttttaaat tcaatgacat tcccaacctt agcgattttc acaagcttcc tctcctttaa 1329061 acataataat gccttttgaa agtattttgc agtattttca ttgagaagta aagcgataag 1329121 gagttttatc tcccttatga attgttctgt cgctataaag atgatatatt gattttcgtc 1329181 aatagaaaga aaagggggga atttttgttg cgtcccgaag aaataacaga aatgattgaa 1329241 cagctgcgca ccggcgccat aaacgaactg agagtccaga aagagcattt tcttgatttc 1329301 agggccgtgt tatctaaaca agatgatttt aaacatttcc gaggaattgc ccagcaaggc 1329361 ggagatgtta tctttcaata cttagaacag ccaagaagct gaaggtttct catacgtgag 1329421 aagccttttt atcatatatg acagaacaca agccttttat tacagctgtc tgtaacaggt 1329481 gtaaataaaa tgtaaagtac caaagatgga taaacatgtt ttaatttaac aatatttata 1329541 gaatttcaga ctgttttttt gccattaagc agtgagtcat cctctttatt ccatcctgat 1329601 acctccttgg gagagttgga aaatcttttt ccgtgaaaat gaatggatct cttgttaagg 1329661 ttatgaagtg ttttttggag cactttaagg aggaaactgt atgacaacga aattcactgc 1329721 tctggctgtt tttcttcttt gtttcatgcc tgcagccaaa attgagcata cacaagcttc 1329781 actactgagc gcaaagaaga caaaacatga agaagcgaaa tggcttacac atatagatcg 1329841 aaatacgaat gaatctttcc cttcactgtc tgctgataaa gacaagaaaa taaaaccgat 1329901 taagctatca gcacacactg aaaagaaaga gaaagataaa ccggacaaaa caaatgatga 1329961 gaaagaaaca tatacacagt ctgaaaaaga gttgctgtcc cgtctcgttc acgcagaggc 1330021 caaaggagaa tcatataaag gcaaggtcgc tgtagcaagc gttgtactga acaggacgga 1330081 gaaaaaaggt tttcctgata cgataagagg agttatttat cagaaaaacg cctttgaacc 1330141 ggtcgcaaac gggagcatta accaaaagcc tgataaagaa tcgattgaag ctgccgaaga 1330201 agcgctgtcc tcaaaaaata gagaaacaga tgccatattc ttttataatc cgaaaacagc 1330261 gtcagataat tggattcgtt caagaaaaat cgtagaaaaa atcggcagac acgtttttgc 1330321 cgtctaagca tagaagagac aatttgtctc agctgtgctt tttttcatat aaagagtaaa 1330381 aataaaataa tttttgaact tgtctcatat gatgttggta gtacaagaga caaggagaga 1330441 catcatgaat cgatttgtga aagggatcat tcttttatcc attgccgcct ttttcgctga 1330501 atgccttgaa tttgtcgtca atatgatttt ggcgcgggag cttggcgagc atgggatggg 1330561 gctttacatg agtattttgc ccacgatctt tttaattatt gtcatcgcga gcctggaact 1330621 gccgatatcc atttctaaat tcattgccga gtcaaatcct aagcttcatg aaagcatgct 1330681 gaggcacgct ttcagaatga cagccatttt tactgctttt tctactgccg ccgctagtat 1330741 tgcgcttccg tttattccgg tatttgatac ataccacccg tttattaaag ggattgtcat 1330801 cggcttaatt cctgttgtcg cctttacttc aatcgccagg ggctacttta tgggtgtgca 1330861 gaaaatgggg aagatcgcaa ttgccaatgt gctgaaaaaa atcatccagc tcttgtgctt 1330921 attcctcttt tttcaatggt actcatttga attggacatg gctgtgctga tttccttgtt 1330981 tgttctagtc gtgagtgatg tggtcgtgct tgtttattta tattcacaat ttatcatggc 1331041 aaggcgggcg ttatccggcc agcagcacat tcatttgcgc ggaaaggatg taaggaaaag 1331101 actgcttgct gtttcaattc ctacaacagg actgcgtatt tttcatgcgg ttgtcaatgc 1331161 aattgaaccc tttttagtaa aaggagctct tttggctgcg ggcgttgccg ggacagcggc 1331221 gatcgatcaa tacggaatgc tggcaggagt ggctgtgacg atagggtcgt tccctgcttt 1331281 tattgcccat tcgttaatgg tcgtcatgat accgagtatt tcggaagctt atgcactttc 1331341 tcagtatgac atcgtgttaa aaaggctgaa gcagtcgatt ttcattacat taggttacgg 1331401 tatacctgcc gtctgggtca tgttccagtt tgcgggacct ctcacgcatt tgttttttca 1331461 ctctcctgaa gcgcagtatt acttgcagct gttgtggcct tactttctct ttcatctgtt 1331521 tgtcatgccg ctgcaggcgt gcttaatcgg gatgggtttt gtgaaagagg ctttttatca 1331581 caatgtatgg agccatatcg ttgcgctaag tatgatgtat gtactgggat caatggagaa 1331641 tctgcaaatg ctcgggatta tccttggaat gaacactggc atgattcttt tgacgagcct 1331701 gcactatgcc acgatctgca aagcattgaa ggtatctgta tttcttacgg gagggaccag 1331761 aacgccgcga attgaaggat gataaaggaa cagcaggggc aagctaattg aaaagcatga 1331821 aaggaagatt ccatgttgac gaagcgcttg cttactatat acattatgtt attagggttg 1331881 attgcatggt ttccaggtgc ggcacaagct gaggaaaaac agcctgctgt tcccgctgtt 1331941 tttcttatga aaacgataga aggggaggac atctcgattc cgaataaagg gcaaaaaaca 1332001 attctccatt tttggacgtc atggtgcccg ccctgcaaaa aggagcttcc acagtttcaa 1332061 tcgttttatg atgcccatcc atccgacagt gtaaagctgg taacggtgaa tttagtgaat 1332121 tcggaacaaa atcagcaagt cgttgaagac tttattaaag caaacaagct gacgtttccg 1332181 attgtccttg actcaaaagg ggaattgatg aaggagtatc atatcatcac gatcccaaca 1332241 tcatttttgc tgaatgaaaa gggagaaatt gaaaaaacaa aaattggccc gatgacagcg 1332301 gaacaactga aggaatggac ggaagaatag ctgagagcat agactctcag cttttttcat 1332361 atagagaaga agtgaataaa cattaatgat aattattatc aaaaagaaat taaaataatt 1332421 ataattgaaa ttctcttcgt gcgtgctata ataaaggaag acatcaagaa ataactgacg 1332481 ataaagctgc cttttgggca gcgattttgt ttttataaga gaaatgaaga tgatttacgt 1332541 tctcaattag agaggagaat tcgatatgaa tgaacaagtt atcgttcaac gcgacccgca 1332601 tgagccattg aaaacagaca agagggaaaa aaactgggca cagcacgcgg agcttattgc 1332661 agcacttgta tcaggcgctc ttattttggc aggctggctc ttatccggat atcaggtatt 1332721 atccataata cttttcttgc tggcttttgt gatcggcgga tttgctaaag cgaaggaagg 1332781 aatcgaagaa acactcgaat ccaaaacgct gaatgtagaa cttttaatga ttttcgctgc 1332841 cattggttcc gccttgatcg gatactgggc agagggtgct attttaatat ttattttttc 1332901 cttaagcgga gctttagaaa catacacgat gaataaaagc agcagagatt taacgtcttt 1332961 aatgcagctt gagcctgaag aagcgacatt gatggtcaat ggtgaaacca aaagagttcc 1333021 ggtttcagac ttgcaggccg gtgatatgat tgtgatcaaa cctggagaac gcgtagcggc 1333081 agacggtatc attgaatcgg gctcgacaag tcttgacgag tcggctttaa caggtgaatc 1333141 aatgcctgta gaaaaaaaca caggcgacac tgtattcaca ggaacggtga atcgcaatgg 1333201 ctccttgaca gtccgtgtca cgaaagcaaa tgaagattcg ttattcagaa aaattatcaa 1333261 actggttgaa tcagcgcaaa atagtgtttc acccgcgcag gctttcatcg aacgatttga 1333321 aaatgcttat gtgaaaggtg tgctaattgc ggtggcgctc cttttattcg tcccgcactt 1333381 tgcgctgggc tggagctgga gtgaaacctt ctaccgcgca atggtgttta tggttgtcgc 1333441 gtcaccttgt gcgcttgtcg cctctattat gccggcggcg ctgtccctga tttcaaatgg 1333501 cgcccgcaac ggtatgcttg tgaaaggaag cgtctttctt gaacagctgg gctcagtgca 1333561 aatgatcgcc tttgataaaa ccggaactgt aacaaaaggc cagcctgccg tagagacgat 1333621 cagaatagca gaaggattca gtgaagcgga agttcttgag gctgtctatg ccatcgaaac 1333681 gcaatcaagc catccgctcg cccaagccat aacggcgtac gctgaaagcc gcggcgtgaa 1333741 tcagtccggc tacatatcta tagaagaaac ctcagggttt ggcgttatgg cagaagtgtc 1333801 gggtgcgaaa tggaaggtcg gtaaagcagg ttttatcggc gaggaaatgg cagcacaatt 1333861 tatgaaacaa acagcatcag atgtcattca aagcggtcat acaattgtat ttgtgaaaaa 1333921 ggatgatcaa atagcaggct gtatcgcact gaaggaccaa atcaggcctg aagcaaaaga 1333981 ggtcatggaa gaactgaacc gacttgggat taaaacggcc atgctgacag gagatcacga 1334041 agacacggct caagcgattg ccaaggaagc cggcatgaca actgtcgtgg cagaatgcct 1334101 gcctgaccaa aaagtgaatg aaatcaaacg gttaaaagaa gaattcggaa cgattgcaat 1334161 ggtgggtgac ggaatcaatg atgcgccggc actcaaagca gcggatgtcg gcattgcgat 1334221 gggcggcgga acagatgtag cacttgagac cgctgatatg gtcctcatga aaaacgattt 1334281 gaaaaagctc gtaaacatgt gccgcttgtc tcggaaaatg aacaggatca tcaaacaaaa 1334341 tatcgtgttt tctctagctg taatctgcct gctgatttgt gcaaactttt tgcaggcgat 1334401 ggaattgcca tttggcgtga ttggtcatga gggcagcacg attttagtca tactaaacgg 1334461 tttaagactc ctaaaataaa accagcagcc taatcaggct gctggctttt tatgtatcaa 1334521 gctttccctt catttttgtc tttatcagat cttttcataa ctaggatgag agcgagggtg 1334581 cagcaaagga aacccgctgc acagcctatg atagagctgt aataataaaa gcccaccatc 1334641 ttcatcccga taaaaggagc ggaaattccc aaaaccgtta agagcataac tgcttttcgt 1334701 ctgaaaaaat tcatcagcaa acggaacaac ccccctgcga ttgaacgtta ctgtcagtat 1334761 acaggaagag gagcaggaaa taaaatgcat tagaaaatga aggcgtcgtg aaaggcaaac 1334821 accggtaaaa cctgttacaa tggaagacag aacaatgcat tgcaaatggc agggaggaac 1334881 aagaagtgaa tagaatacaa cgcgtctctt catggctgaa ggaagcgggg catactgccg 1334941 catttattca tacgaaagaa aatgtttttt acttaaccgg tttttacaca gagccgcatg 1335001 aaagattaat ggggttattt atttttcaag aagaggagcc tttctttgtt tgtccaggaa 1335061 tggaagcagg acaggcccgc aacgcaggct ggaatcatga aatcattggc tatgcggatc 1335121 acgaaaatcc gtgggagctg atagagaagg ctttgaaaaa gcgaaatatc agcatacata 1335181 tgcttgcggt agaaaaggat tcaatctcgc tgtcacgtgc agaacagctg aagcatgcga 1335241 cgggcggggc tcaatttgtt tcagcagaag aaacactcaa tcaatttcgc ctgattaaag 1335301 atgacaatga gattcgtttg ctgaaagagg cggcaaagct tgcagattac ggtgttgaag 1335361 tcggcacagc cgctttgcgt gaaggcatca gtgaagtgga agtgctcgct caaattgagt 1335421 atgagctgaa gaaaaaagga attcagggca tgtctttctc tacaatggtt ttattcggag 1335481 aaaaatctgg ccagcctcat ggaaatcctg gtacagccac gttgaagaaa ggtgattttg 1335541 ttttatttga tctcggtgtt attcttgatg gctattgctc tgatattaca agaacgtttg 1335601 catacaaaac catcaatccg aagcaggagg ccatttacga gactgtgctt caagcggaaa 1335661 aagccgcgat tgaggcaagc aaacccggtg tgagaatcgg agatctggat ttaactgccc 1335721 gcggaatcat tgaaaaagcg ggatatggtg attattttcc tcaccggctt gggcatggac 1335781 tcggaatttc agtccatgag tatccatcaa tgagccaggc caacgataca ctgctgcagg 1335841 aaggcatggt ctacacgatc gaaccgggga tttatgtgcc agagatcggc ggcgtacgca 1335901 ttgaggatga cgttcacgta acaaaggacg gagcagttgc tctgacccaa tatccaaagg 1335961 atttgatcat actgtaatag aaataaaaaa ggactttgtt ctcgacatcg tcctttttta 1336021 tctgcattaa ataaaaaaat catcaaatgt tcgaaagggt ttaatttcat gtttttggtt 1336081 gagaggtttt acagcaagac agctgccacc gagaacagtg agacataacc caattaaaat 1336141 gaagaaaccc atgtgatctt ctcctttcag ctaaaaacac aaaaagatat ctggtacgtc 1336201 catatcatat tgtatgaaac gcattccaga tcaaggggat ttagaaagaa gggaatctat 1336261 ggctaatatt aaagacattg cagagaaagc cggtgtctct gttacaacgg tttcccgagt 1336321 cataaacaat catccatacg tcagtgaaga caaacgaaaa agagtgtttg aggcaatgga 1336381 atcattggag tacacgagaa atattcacgc tgtacatttg tcgaaaggat tttcaaacat 1336441 gattggtgtt gtcttgccga cggttaatct gccatatttt gcagagctga ttgcaggaat 1336501 agccgacgca gccgcggaat ccggggttca cctctcttta ttccaaacaa actatgaagt 1336561 acaaaaagaa atctttgcgc tgtcccaatt aaagcagcgc caggttgacg gcctgatttt 1336621 ttgctcaaag gcgcttgctg atgagaaact catggaatgg gagggcccga ttttgctttg 1336681 ccagaattca gataatgccc gcttcccaac catcagcatt cctcaccaag aagcatttcg 1336741 gaacggcttg gactatttaa ttgccaaagg gcacaaaaaa atagccatct gtttggcaag 1336801 aaaaaaaggc atgaacagcc attttcgaat caaagcctac aaagaggcat tggaagagat 1336861 cggcgaggca tttcgtgaag actgggtaat tgagaaagcg attacaatca atgatgggaa 1336921 ggcgcttttt cataaatgga atacgtggaa ggaaaagccg acggctattt ttgttgccaa 1336981 tgaccaagtc tcagcagggc tttttcttga agcaaagaac cagcgggtgt cagtaccgga 1337041 tgagcttgca atcttaagcg ttgataacca cgaaatcagc caagcgcttg gaatcacaac 1337101 gatcgatatt cagacaaggg aaatgggaaa gcaggcattt gccatattgg aaaaaagaat 1337161 tcaaggacag ccgattgaaa ggaaagttct ggattaccgt ctcatcgaaa gatcgactgt 1337221 ttagtgaatg cattgaaaaa aggtttgacg tgcattctgt tcgttatgta cgatatgagg 1337281 tattgaatga caaaggagct gaggatcgtg aatgggtcct tcacagtgaa aaaggtactg 1337341 aataataacg tattaattgc ttctcatcat aaatacagcg aagtcgtttt aatcggaaaa 1337401 ggtattggtt tcggaaaaaa acaagatgat gtcattgaag ataaaggcta cgataaaatg 1337461 ttcattttaa aagacgagaa ggaacaaaag cagtttaaaa agctccttga ctatgttgat 1337521 gaaaagctcg ttgatatttc aaacgatgtc atctatcaca taagcaatag gacgaatcac 1337581 tcattaaatg aacatattca cattgcgttg acagaccata tcgcatttgc gatcaaaagg 1337641 cagcagcagg gatttgatat gaaaaatcca tttctaatgg agactcagtc actatatcct 1337701 gaggagtacc aaattgccaa agaagtcata gatatgatca atgaaaaagc gggactctgc 1337761 cttccggaag gggagattgg ttttatcgct ctgcatatcc attcagcgtt gacaaaccgt 1337821 ccgctgtccg aggtcaatca gcactctcag ctcatggcgc agcttgtcga ggtgattgaa 1337881 gactcatttc aaatgaaagt aaataaggaa agtgtcaact atttgcggct gatcaggcat 1337941 atcagattta caatagaaag aattaaaaaa gaagaaccga ctaaagaacc agaaaaatta 1338001 atgttgttat tgaaaaatga atatccgcta tgctacaata cagcttggaa attgattaaa 1338061 atcttgcagc aaacattgaa gaaaccagtt catgaggcgg aagcggttta tctgacgctt 1338121 catctgtacc gattaaccaa taaaatttca taaattcagt ttatccttat aacgtgttac 1338181 tgattcgatc aggcatgagt gattgaggga aaaaaacggg aagttcattc tcgttctttt 1338241 gcgcacccaa ttttgctcat gcctttttgt tgtgtaaaag ggcaaatgta aacggttaaa 1338301 ctggaagact tacgcctgtg aattcgttgt catgattttt agctgtaagg tcagactagt 1338361 aaaaagagga ggtcaattct tatgtttaaa gcattattcg gcgttcttca aaaaattggg 1338421 cgtgcgctta tgcttccagt tgcgatcctt ccggctgcgg gtattttgct tgcgatcggg 1338481 aatgcgatgc aaaataagga catgattcag gtcctgcatt tcttgagcaa tgacaatgtt 1338541 cagcttgtag caggtgtgat ggaaagtgct gggcagattg ttttcgataa ccttccgctt 1338601 cttttcgcag taggtgtagc catcgggctt gccaatggtg atggagttgc agggattgca 1338661 gcaattatcg gttatcttgt aatgaatgta tccatgagtg cggttcttct tgcaaacgga 1338721 accattcctt cggattcagt tgaaagagcc aagttcttta cggaaaacca tcctgcatat 1338781 gtaaacatgc ttggtatacc taccttggcg acaggggtgt tcggcggtat tatcgtcggt 1338841 gtgttagctg cattattgtt taacagattt tacacaattg aactgccgca ataccttggt 1338901 ttctttgcgg gtaaacgttt cgttccaatt gttacgtcaa tttctgcact gattctgggt 1338961 cttattatgt tagtgatctg gcctccaatc cagcatggat tgaatgcctt ttcaacagga 1339021 ttagtggaag cgaatccaac ccttgctgca tttatcttcg gggtgattga acgttcgctt 1339081 atcccattcg gattgcacca tattttctat tcaccgttct ggtatgaatt cttcagctat 1339141 aagagtgcag caggagaaat catccgcggg gatcagcgta tctttatggc gcagattaaa 1339201 gacggcgtac agttaacggc aggtacgttc atgacaggta aatatccatt tatgatgttc 1339261 ggtctgcctg ctgcggcgct tgccatttat catgaagcaa aaccgcaaaa caaaaaactc 1339321 gttgcaggta ttatgggttc agcggccttg acatctttct taacggggat cacagagcca 1339381 ttggaatttt ctttcttatt cgttgctcca gtcctgtttg cgattcactg tttgtttgcg 1339441 ggactttcat tcatggtcat gcagctgttg aatgttaaga ttggtatgac attctccggc 1339501 ggtttaattg actacttcct attcggtatt ttaccaaacc ggacggcatg gtggcttgtc 1339561 atccctgtcg gcttagggtt agcggtcatt tactactttg gattccgatt tgccatccgc 1339621 aaatttaatc tgaaaacacc tggacgcgag gatgctgcgg aagaaacagc agcacctggg 1339681 aaaacaggtg aagcaggaga tcttccttat gagattctgc aggcaatggg tgaccaggaa 1339741 aacatcaaac accttgatgc ttgtatcact cgtctgcgtg tgactgtaaa cgatcagaaa 1339801 aaggttgata aagaccgtct gaaacagctt ggcgcttccg gagtgctgga agtcggcaac 1339861 aacattcagg ctattttcgg accgcgttct gacgggttaa aaacacaaat gcaagacatt 1339921 attgcgggac gcaagcctag acctgagccg aaaacatctg ctcaagagga agtaggccag 1339981 caggttgagg aagtgattgc agaaccgctg caaaatgaaa tcggcgagga agttttcgtt 1340041 tctccgatta ccggggaaat tcacccaatt acggatgttc ctgaccaagt cttctcaggg 1340101 aaaatgatgg gtgacggttt tgcgattctc ccttctgaag gaattgtcgt atcaccggtt 1340161 cgcggaaaaa ttctcaatgt gttcccgaca aaacatgcga tcggcctgca atccgacggc 1340221 ggaagagaaa ttttaatcca ctttggtatt gataccgtca gcctgaaggg cgaaggattt 1340281 acgtctttcg tatcagaagg agaccgcgtt gagcctggac aaaaacttct tgaagttgat 1340341 ctggatgcag tcaaaccgaa tgtaccatct ctcatgacac cgattgtatt tacaaacctt 1340401 gctgaaggag aaacagtcag cattaaagca agcggttcag tcaacagaga acaagaagat 1340461 attgtgaaga ttgaaaaata agggtgttag tacgccgtgc ttgtcagatg acaagtacgg 1340521 ttgtatgata taatattgtg aagtaataaa gctttaagtt aaaaggagaa tgataaaaat 1340581 ggcacaaaaa acatttaaag taactgcaga ttctggaatc catgctcgtc ctgcgacagt 1340641 tcttgtacaa actgctagca aatacgacgc tgacgttaat ttagaatata acggcaaaac 1340701 agttaacctt aaatctatta tgggtgttat gtctttaggt atcgctaaag gcgctgagat 1340761 cacaatctct gcttccggag ctgacgaaaa cgatgctctt aacgctttag aagaaacaat 1340821 gaaaagcgaa ggactcggcg agtaatgcaa gaattaaaag ggattggtgc ttcagccggc 1340881 atcgcgattg caaaagcgta ccggcttgaa gagccagatt taacggttga aaagaaaaac 1340941 atctctgatt ctgaagcgga agtaagccgt tttgatgaag cgattgcacg ttcaaaagaa 1341001 gagctcgaaa aaatcaaaga gcacgctttg aaagaactgg gtcaggataa agctgatatt 1341061 ttttctgctc accttttagt tctcagtgac cctgagcttc tgaaccctgt gaaagaaaaa 1341121 atcagcactg attcagtgaa cgctgaattc gctttaaaag aaacgtcttc tatgttcgtt 1341181 actatgtttg aatctatgga caacgaatat atgaaagagc gtgcggcaga tatccgcgat 1341241 gtaacaaaac gcgtaaccgg ccacctgctt ggcgtcgaaa ttccaaaccc aagcatgatc 1341301 tcagaagagg ttattattgt agctgaagac ttaacaccgt ctgacacagc tcaattaaac 1341361 cgtgagttcg taaaaggatt cactactgat atcggcggac gcacatctca ctctgccatc 1341421 atggcacgtt ctcttgagat tccagcagtt gttggaacga aagctgctac aggcacgatc 1341481 caaaacggcg tgactgttat cgttgacggt atcaatggcg atgtcattat tgacccatct 1341541 gcggaaactg taaaagagta tgaagaaaaa cataatgctt atttggctca aaaagctgag 1341601 tgggcgaagc ttgtcaatga accgactgtc tcaaaagacg gacatcatgt agagcttgca 1341661 gcgaacatcg gtactcctga tgatgtaaaa ggtgttcttg aaaacggcgg agaagcagtt 1341721 ggcctttacc gtacagaatt cctttacatg ggaagagatc agctgcctac agaagatgag 1341781 cagtttgatg cttacaaaac ggttcttgag cgtatggaag gaaaatcagt cgtcgtgcgg 1341841 acacttgata tcggcggaga caaagagctt ccttacctgc agcttcctaa agaaatgaac 1341901 ccgttcctgg gatatagagc gattcgtctt tgccttgaag agcaagaaat cttcagaaca 1341961 cagcttcgcg cgctgcttcg tgcaagtaca tacggaaact tgaaaatcat gttccctatg 1342021 attgcgacag ttaacgaatt caaagaagca aaagcgatcc ttcttgaaga gaaagaaaag 1342081 ctcgtaaaag cgggacaggc tgtatctgac gatattgaag tcggaatgat ggttgagatt 1342141 ccgtcaactg cagtcatcgc tgatcagttt gctaaagagg ttgatttctt cagtatcgga 1342201 acaaacgatt tgattcaata cacaatggca gctgaccgta tgaatgaacg tgtatcttac 1342261 ctgtatcagc catacaaccc ggcaatcctt cgcttaatta cactggtaat tgaagcagca 1342321 cacaaagaag gaaaatgggt tggcatgtgc ggagaaatgg caggagacga gattgcgatt 1342381 ccgatccttc tcggcttagg cttagatgag ttctcaatga gcgcaacgtc tatccttccg 1342441 gcaagaacac aaatcagcaa attgtctaaa caagaagctg agtcattcaa agagaaaatc 1342501 ttatctatga gcacgacaga agaagttgtc gcgttcgtaa aagaaacatt caagtaatgt 1342561 acaaaaacca gacggcctcc ggcctgtctg gtttttttca taagtaaggg tatagaagga 1342621 cacaataaca tggctaggag ggatagtatg tcaaaccaat ttaacgcagg agatactgtt 1342681 tatgtgatct acagaaatcc gcacgccgcc aatgtagccc acataaagga agccgaaatt 1342741 gtgcaccatc cataccatga aggcgagctt tccctgttta tttatgaaac ctatcatcca 1342801 ttcgcagagg acgatgctgt gtttgcaagc tatgaagaag ctaaatcgct ttacaaagaa 1342861 ctgtttgata ttgatccgta tgagtaacaa ggaaatcatt acaactcata tcctttccgc 1342921 ctagtgagaa aagtaacgtt agtaaaggaa aaggatgtgg catcatgcag aacccatttg 1342981 ttccgcagct tgtgtatata gaaccgaggg cgctggaata tccgctgggc caagaattac 1343041 aagataaatt tgagaatatg ggtattgaaa tcagagaaac gacatcccac aatcaggtgc 1343101 gtaatatccc tgggaaaaat catcttcagc aatatcgcaa tgcgaaatca actttagtta 1343161 tcggtgtccg gaaaacatta aagtttgatt catccaaacc ctcggccgaa tatgccattc 1343221 cgtttgcaac aggctgcatg gggcattgtc attactgcta cctgcaaaca accatgggat 1343281 caaagccgta tatcagaact tatgtaaacg tcgaagagat tttagatcag gcagataagt 1343341 atatgaagga gcgcgcacca gagttcacaa ggttcgaagc atcatgtacg tcagacattg 1343401 taggaattga tcatctgaca cacacgctga agcgcgccat tgaacatttt ggccaaagtg 1343461 atctcggaaa gctccgattt gtaacgaaat ttcatcatgt cgatcaccta ttagacgcaa 1343521 agcataacgg gaaaacgaga ttcagattca gtattaatgc cgactatgtg attaaaaact 1343581 ttgagccggg aacttcacct cttgataagc ggatagaagc ggcagtaaaa gttgcaaaag 1343641 caggctaccc gctaggcttt attgttgctc cgatttatat tcatgaaggc tgggaagaag 1343701 gatacagaca tctgtttgaa aagctagatg ctgctttgcc gcaggacgtt agacatgaca 1343761 ttacgtttga attaattcaa caccgtttta caaaaccggc caaacgagtg atagagaaaa 1343821 attatccgaa gacgaagctc gaattagatg aagaaaagcg ccgttataaa tggggccgtt 1343881 acgggatcgg aaaatatatt tatcagaaag atgaagagca tgcacttcga gaggcacttg 1343941 aatcctatat tgataccttt ttccctaacg caaaaattga atatttcact taaacgggct 1344001 gttgtgatca acagctcgct tttttataaa aaacattttt ccattccatc aaaacgccgt 1344061 aattcaatga ttctttatcc tccaaataat tgctgactac acgaataggt gaacgcccgc 1344121 aacggaggag aaaggacagc acagggtcgt ttttcctgcc ttccatcaca tcttcaacgt 1344181 actgaacagc gctgatctcg tgtgcgtatt tataatacaa aggaatgcgg ccgccgccga 1344241 gaaggcgttc cagtctttta tcaacagtca gctcatacat cgtattcatc agccattttc 1344301 cgattccaag ctttcgataa tgaggagaaa cagaaatatc cactacatat aaagtatttc 1344361 catgaggttc atgattttta atcgatccgt tgtcagttgc ttgtgcccat gtatgatcag 1344421 gagaatcagg ctcaaattgt acaataagag cagtcatgga accgataatt ctgccattga 1344481 tgagcgcgca taaagcgcct tccggaaagg ttttgatatg gctggcaagc tggtcctctg 1344541 accacagcaa ttcctgggga aacggaggag ggaaacattc ttcttgaaga gaaatcagcc 1344601 tctcgatgtc agtctcagtg tagtttctaa tggtcagagc ctcaaatttt ctgccgtcat 1344661 gcacatacat ttgttttagt atgatcatca ctctccttat gttgtttcat tataacgaag 1344721 attgaatttt cagtaaatat attccgattt tcttataatt tattttttga ttattcattt 1344781 ttcaaacgaa agggccgata tagaaattag gaggggattg gtttgtttaa aaaacttcac 1344841 atgaagattg ctgtttttgt ttcgattatg ttaatcatca cagttgttct cttaatgctg 1344901 tcttcttatt tgacgctaaa accgatgatt acagaggatg ggaaaaatac aactcaaaac 1344961 gtgacgcagt cacttgaaca aaatattgaa ttgcaattaa agagttatgc catttcgtta 1345021 tcaagattgg ctaatgggga attaacgcat acatttgtaa cgaaaccaag taaagaagct 1345081 tctcggctgt ttcacgatga cattaagcaa atcaaagaca acgatgatta tgttgcgatg 1345141 gcttacatag gcaccgcaaa aaaagaaatg tttacatatc caaaagcgga tttcgctgag 1345201 gattacgatc caacatcaag accatggtat aagcttgcag ctgaaacccc ggatcaagtt 1345261 gtttggacgg aaccttataa agatgtcgtg acaggagaca tgattgttac tgcatcgaaa 1345321 gcgatcttag acaggcaaaa agtgataggg gttgccagct atgacttgaa actctctgct 1345381 atccagagta tggtcaataa acaaaaggtg ccttacaaag gatttgcctt tttagctgat 1345441 gcgagcggca atcttttagc ccatccgtca aatcaaggaa aaaatatatc aaaggatcaa 1345501 acactgcaaa ccatcgcatc cgagaaaaaa gggatacaag atgtgaatgg gaaaatggtt 1345561 gtgtaccaaa cgattggcga gacaggctgg aaggtcggaa cgcaatttga taccgatcaa 1345621 ttaatgtgga tttcagataa aatgaatcgg gccaatcttt ggatatcatt gattgcgctt 1345681 atcataacaa ttattctcag ctacttcctg gccaaaacga taaccggtcc gatacagcag 1345741 ctgatcgtaa aaacgaaagc tgtttccgca ggcgatttaa cagtgcgcgc ggaatcaaaa 1345801 tctaaggatg aagtcggtat tttaacaaga gatttcaatc tgatggttga aaatatgaag 1345861 gaaatggttg agcaagtgag actctcttca gggaaagtat ctgacacctc tgaacaacta 1345921 acggctgtgg ctgccgaaac taatgaaaca agcggacaaa ttgcaaaagc gattgaagaa 1345981 gtagccgcag gggcatcgga acaggcttct gaagttgaaa ccattaatga aaaatcggaa 1346041 agcctgtcaa cgaaaatcag gcaaatcgct gaggaggcag gcggaattaa agaacgctca 1346101 aaatcgtccg aggatgcaag ctataaagga cttgacgcgc tcggccagct gctgatgaaa 1346161 tcaaacgaag ccaatatgga aacgaaaaag gttgaaacga tgctgctgga tttggaaaat 1346221 caaactaaga atattgaaga agtcgttaca gcgatttcaa acatatctga tcaaaccaac 1346281 ttgcttgcct taaatgccag tattgaggca gccagagccg gagaaagcgg gcgcggtttt 1346341 gccgtcgtag ccgatgaagt gcggaagtta gctgagcaat cagccctttc tacaaagcat 1346401 atcagcgaga ctgtgaagct tatccagctt gagacaaaag aggcctctca cgcgatggtt 1346461 gaggcaagca gaatgaatga tgaacaaaac agtgcaattc acgaaactgg agaggtatta 1346521 aatacgataa ctgcagaaat gcagtcactg gtacaaggta ttgatcacat ttacgcggaa 1346581 attcaaagaa tgagtgaaga acagcttgcg atttctgaag ccattcaaag catttcagcc 1346641 atatcacagg aatcagctgc cgcagcagag gaagtgaacg catcaaccga tgaacagctt 1346701 gtcacccttg ataaagtcaa acactcaacg gaaacactaa aacatgcaag ccaagagctt 1346761 atgaacacaa ttgcaaaatt cacattgtaa tccaattaca tccccaaaca tcatttgttt 1346821 tggggatttt ttattttata agatgaatag atatggtagt ctagaaaatg aaggaaaaat 1346881 gataaatttt aactaaaatc taaacgaaac atctgggagg aatgaccttg aaaaaaacaa 1346941 ttggttttat cggtcttgga gtaatgggaa aaagcatggc atcacatatt ctcaatgacg 1347001 gccatcctgt attggtgtac acccggacaa aagaaaaagc agaaagcata cttcaaaaag 1347061 gcgcgatctg gaaagatacg gtcaaagatc tttcgaaaga agcggatgtt atcatcacaa 1347121 tggtcggcta tcccagtgat gttgaagaag tgtatttcgg aagcaatgga attattgaaa 1347181 acgcaaaaga aggtgcatat cttattgata tgacgacatc taagccttcg cttgcgaaga 1347241 agattgctga agcggccaaa gaaaaagcat tgttcgcttt agacgctcct gtttccggtg 1347301 gagacatcgg tgcacaaaac ggaacactcg cgattatggt cggtggagaa aaagaagctt 1347361 ttgaagcctg catgccgatt ttctctttaa tgggagagaa tattcagtat caaggaccgg 1347421 ctggaagcgg acagcatacc aagatgtgca atcagattgc aattgcagcc ggtatgatcg 1347481 gtgttgctga agcgatggct tatgcccaaa aatcaggcct agagccggaa aatgttctga 1347541 aaagcatcac aacgggcgca gccggaagct ggtcattgtc aaatcttgct ccccgtatgc 1347601 tgcaaggcaa ctttgaaccg ggattttatg tgaagcattt tattaaggat atgggaattg 1347661 cactagagga agcagaatta atgggggaag aaatgccagg cttgtcgctc gcaaaatctt 1347721 tatatgacaa gctagctgct caaggtgaag aaaacagcgg aacacagagt atatataagc 1347781 tttgggtgaa ataaaaaaag attgcctgta cgaaacaggc aatctttttt tattattttc 1347841 cgatgaattg ttgtgtccag atgcttccag actcaacgta accaacaccg atgtgagtaa 1347901 agttagggtt tagaatgttt tttctgtgtc cttcactgtt catccaagct tttactactt 1347961 cttctggtgt cttttggccc ttcgcaatgt tttcacctgc tgttttgtag ctgattccga 1348021 aagatttcat catatcaaac ggtgagccgt atgttgggct ttggtgatca aagtagtttt 1348081 tgtctttcat atcctgagat tttgcgcgtg cagatttgct taacgtttca tcaatttgaa 1348141 gcggttttaa gccttgtttt tgtctttctg catttgtaag ttcaacaact tttttctcat 1348201 atgcacttac agatgaaggt gcagacgttg ttgtgtttgt tttttcagca gttgcgggtg 1348261 ctttagaagc agtgttttga tcagcagctg ctttttcagt agtcttttgt gcaggttttg 1348321 ccgtttctgt cttttgaaca tcctgaactt tcacgttaga ttgcttcgca tgtttttgaa 1348381 gaagctgctt catctctttt tcgtttgcag cgtttaacgt tttgatattt gtgttaatat 1348441 gcagtttttt cactgcatcg ttaagtgaca tgttttgtac tgtgttcccc gtttttactg 1348501 taaccacagg ctggcaggag agttctttcg ctgatgcttg ctgtacgccc ccgaatgtga 1348561 ataatccaac cgcagcggca gcagataaaa taaatgcttt cttcattagt tcgtaacctc 1348621 ctagagttgt ttgtttctac agaaaaatca taacatagct tttttgtcat aaagattcca 1348681 gcactttcct ttgacaaata gagattgtca ttttcgtaaa gtaaatccgt tgaatcacta 1348741 agaataaggg aatcagcggt atatatgatt ttatcgtacc gttacatagc ttcctttttt 1348801 ttgaaccgtt agttatattt taatgtgttt ttatattgac agcttttttt actccttttc 1348861 gctgtaacaa ctattacaaa ggtgttacaa ttaatctcag tatatgtaaa tatattgaat 1348921 gatttgagag gggtaaccag aagtgactga aataggacgt gaaccaaaga aaaagagcaa 1348981 aggaaacaga gcaatcagaa tgaacctttt tttcctagct gtctttgttc tattcactgc 1349041 attaattttt aagctcgggg ttgttcaaat tgttgaaggc gaacagcatg aagaagacgc 1349101 tgagaaatca aatgcaaaaa cagcttacta tcctgcgcct cgcgggaaga tgtacgacag 1349161 aaaccagaaa gttgctgtcg acaaccagag cgttccagaa attgtgtatg tatcaacatc 1349221 tagcacaaaa acagaagata aaatcaaaac agcgaagcgg cttgcttctt tcattcatat 1349281 tgataccgaa tttttgaagg aaagggatct tcgtgattac tggatcgcag ctcatccgaa 1349341 aaaagccgcc gctctgctta aggaatcaga aagcaatctg aaaggagacc aggcttacaa 1349401 gcttcaaata gagcgtgttc cggatcaaga attaaaggct attcagcaag atgacgaaga 1349461 aatggaaact gctgcgatat atacaaggtt ttcaagcgga aatgcttacg aacctcaaat 1349521 cgtaaaggca atgaatccaa ataagagcaa tagcaatgga aaaaacggag cgctgcttga 1349581 tgagaagaaa aactcctcgc aaagaccaaa aaatgactta acatatgatg aaatttccat 1349641 tgtttctgag catttagaag aacttccggg aatcgatatc gtaaacgatt ggacacgaaa 1349701 atatccttat gacaaaaccc tttattctgt tttcgggggc gtcacgacac ctgatcaggg 1349761 cctgctgagc gaccggaaag atttctactt aacaagaggc tatgcgaata atgacagggt 1349821 gggaaaaagt tatttagagt atcaatatga agaatattta aattcgcata aagaaaaagt 1349881 ggaatacgta gaagataata aaggaaatgt cgtcagccaa aaaaccattg ataagggcag 1349941 caggggatac gatcttcagc tttcttttga catggagctt caggcaaagg tagaaaagat 1350001 cattgaagaa gaagtaagaa acagccgtgc acgcggaaat tacatgcttg acagagcctt 1350061 tgccgtaatg atggacccga ataacggcga tattttatca atggcaggga aaaagataga 1350121 tttaaaaacc aacaaaattg aagattatgc gataggggca tttaccaccc aatatgaaat 1350181 gggatcagca gtaaaggggg ccaccgtgct agccggctat caggacggga tcccgcatta 1350241 taaatattat atcgatgctc caatgctttt aggaacgaat cttataaaaa aatcttatac 1350301 taatatggga accatcaatg aattaaccgc attgcaaaaa agttcaaacg tatatatgtt 1350361 caatgttgcc atgcatattg caggcgtaac atacaagccg catggatctc tcccggctga 1350421 tcagaacgat ctactgaaaa tgagaaacta ttacagccag tttggtctgg gagtaaagac 1350481 aggtattgat ctcccgcagg aatcagccgg aatgcaaacc acacctaaaa ctgtaggagg 1350541 attaatttta gacttagcaa ttggccaata cgatacatac acaccgcttc aaatggctca 1350601 atacatctca gtaatcgcca atggtggcta tcgtgttcag cctagaatcg tcacaagtat 1350661 tcataagcca ggaaaaaaag accagctggg taaggcgatt gaacatagga aacctaaagt 1350721 actcaataag attaataatt cagagagcga tttgaaacaa gtacaaacag gcatgaaatt 1350781 agtcacttct tcagggacag caaaaaatac gtttacagaa gatgtatcag ggaaaacggg 1350841 aacagcggaa acattttact acggcacgaa tcgcaactgg tgggggaaaa aaacatacaa 1350901 tctgactttt gtcggctatt acccgtcgaa aaaaccaaaa gtggccttta gtgttgttgt 1350961 tccatcagta gatgatgatg ataagatcaa taaaattatt gccaaaagag ctatccacgc 1351021 ctacgcagag ctcgaaaaaa aacacagtaa aaaataaaaa acagggtgca caactaaaag 1351081 attgtgtgcc ctttctttta ttcaaaaatt gacgttcacc ataagaatag aaggagaata 1351141 ctcattttct agcgaatcat actaggtaaa agtcaatctg tatatgtcga aacacgatga 1351201 tcatgcaaag gagggattct gtggaacagg atacgcagca tgttaaacca cttcaaacaa 1351261 aaaccgatat tcatgcagtc ttggcctcta atggacgcat catttatata tctgccaact 1351321 ccaaactgca tttgggctat ctccaaggag agatgatcgg atcattcctc aaaacgtttc 1351381 tgcatgagga agaccaattt ttggttgaaa gctattttta taatgaacat catctgatgc 1351441 cgtgcacctt tcgttttatt aaaaaagatc atacgattgt gtgggtggag gctgcggtag 1351501 aaattgttac gacaagagct gagcggacag aacgggaaat cattttgaaa atgaaggttc 1351561 ttgaagaaga aacaggccat caatccctaa actgcgaaaa acatgaaatc gaacctgcaa 1351621 gcccggaatc gactacatat ataacggatg attatgaacg gttggttgaa aatctcccga 1351681 gtccgctatg catcagtgtc aaaggcaaga tcgtctatgt aaacagcgcg atgctttcaa 1351741 tgctgggagc caaaagcaag gatgctatta ttggtaaatc gtcctatgaa tttattgaag 1351801 aagaatatca tgatatcgtg aaaaacagga ttatacgaat gcaaaaagga atggaagtcg 1351861 gaatgattga acagacgtgg aaaaggcttg atggcacacc tgttcattta gaagtgaaag 1351921 catccccgac cgtctacaaa aaccagcagg ctgagctgct gctgctgatc gatatctctt 1351981 caaggaaaaa attccaaacc atcctgcaaa aaagccgtga acgatatcag ctgctgattc 1352041 aaaattccat tgataccatt gcggtgattc acaatggaaa atgggtattt atgaatgaat 1352101 cgggaatttc cctgtttgaa gcggctacat atgaggattt aattggcaaa aacatatacg 1352161 atcagctgca tccttgcgat cacgaggatg taaaagagag aatccaaaac attgccgagc 1352221 aaaaaacaga atctgaaatt gtcaagcaat cctggttcac ctttcagaac agggtcatct 1352281 atacggagat ggtctgcatt ccgacgacct tttttggtga agcggccgtc caggtcattc 1352341 ttcgggacat ctcagagaga aaacaaacag aagaattgat gctgaaatcg gaaaaattat 1352401 caatcgcagg gcagctcgcg gcgggaatcg cccatgagat ccgcaaccct cttacagcga 1352461 tcaaaggatt tttacagctg atgaaaccga caatggaagg caacgaacat tactttgata 1352521 ttgtgttttc tgaactcagc cgtatcgaat taatactcag tgaactgctc atgctggcga 1352581 aacctcagca aaatgctgtc aaagaatatt tgaacttgaa aaaattaatt ggtgaggttt 1352641 cagccctgtt agaaacgcag gcgaatttaa atggcatttt tatcagaaca agttatgaaa 1352701 aagacagcat ttatataaac ggggatcaaa accaattaaa gcaggtattc attaatttaa 1352761 tcaaaaatgc agttgaatca atgcctgatg ggggaacagt agacattatc ataaccgaag 1352821 atgagcattc tgttcatgtt actgtcaaag acgaagggga aggtatacct gaaaaggtac 1352881 taaaccggat tggagagcca tttttaacaa caaaagaaaa aggtacgggg cttggattaa 1352941 tggtgacatt taatatcatt gaaaaccatc agggagttat acatgtggac agccatcctg 1353001 aaaaaggcac agcgtttaaa atttcatttc caaaaaaata aaaacaacgg cttaaacgcc 1353061 gttgtttatc gtctgcattg cttcacgttt ttttaataca aataattcta aacggtctag 1353121 gccttctctc agcgtgtcca ttgagcatgc aaaagacagc cttacatatc cttcaccata 1353181 tgttgagaac gagctgcccg gcacgagtgc cacgccagcg tcttccaaaa gagccatact 1353241 aaaatcaaat gaagtcattc caaatgattt aatagaaggg aagatataaa acgcaccgga 1353301 cggtttaact acgtcaagtc ccatggaaac aagacggtca taaacatagt ccagacgttt 1353361 tttgtattgt tctctcataa tcaatgcatc gtcaaagccg tttgtgacag cttcaagcgc 1353421 ggctttttga gaaatggatg aggcgcacga cacattgtat tgatgaacct ttaaaatgtg 1353481 ctttgcaatg tctttcggtg caaataaaaa tccaattctc caaccggtca tgctgtgtga 1353541 ttttgacaac ccgttaatga caatcgtttg atcccgcaaa taggttgcga tggagtaatg 1353601 cggtctgtca tatgttaatt cactgtatat ttcatcagac aatacgaaga catttctgcc 1353661 ttttaagaga gctgcgatgc ttttcagttc ttcttcagat aaagtcacgc cggtagggtt 1353721 tgacggataa ggaagcacga cacacttggt gttgggtgtc agagcatctt caatcagccg 1353781 ggcggtaagc ttaaagccgt gtgacgtagt atcaacaatg acaggcttgg ccccgcacaa 1353841 attgataata ggttcatagc ccggataaat aggccctggc ataatgactt catcaccggg 1353901 agataaaatc gtccggaatg cagcatcaat ggcttggctt gcgcctgttg tgatgataat 1353961 ttcagattca gcatcatagt tgaaatccgc ttttttcttc atataaagct gcacagcttg 1354021 tctcagctcc aggtagccgg cattcggagt atatgacgtc acgttttcat caatggcttt 1354081 ttttgcggca gctttcacat gatgcggtgt gaaaaaatca ggctggccga ttgtaagtga 1354141 aatgacgtct tcgtgttggg ctacaagatt cgagaatttg cgtattcctg aaatttcgat 1354201 ctctcttgct ttcggattca gcaaatgttc cataattcat caccttaaca aatataatga 1354261 gtttatccta ttttaccact agctgatcat ttgtcacctt tttaactgat atatttcgat 1354321 tgtatgcgcc ttttttctaa acataccttt cttttcagaa aaaaagaaga caaccagcga 1354381 tttgattgtc tttattgtat catgttctat tattgtttat atgtgccaat ttcattaata 1354441 gccataatca aaatgaaggt cttcgtgcca aatcagatac ggaggatgct cttcttgaag 1354501 gtcagctgat tctttcttca tattcaggta agtttcttca ctgatatcct ctaaaacagt 1354561 catttcgttt tctttaaata ttactaaggt acccattatt tacacccttc tttggaaaaa 1354621 tccttgacta ttttatcact gttagttgga aagtcaatgg ttattaggaa aaaagtttct 1354681 tttttgagga acgcggcttg ttgccttcgg aattcgattt tgaagagctg ccattcactt 1354741 tttacaaatt acgccgatat atacagtaca atactgaatg cgaatagcga gggattgaat 1354801 tgtcgttaca acaatacgaa attttattgg attctggtac aaatgaatta gaaattgtga 1354861 agtttggcgt gggtgaaaat gctttcggaa ttaacgtcat gaaggtaaga gaaattattc 1354921 agcctgtcga ggtgacatca gtgcctcact cccatcagca tgtagaagga atgattaaac 1354981 tcagaggaga aatcctccct gtgatcagtc tcttctcatt ttttggagta gagcctgaag 1355041 gatcaaaaga tgagaaatat atcgtgactg aatttaataa acggaaaatt gtttttcatg 1355101 tcggctctgt ttctcaaatt cacagagtat cctgggaagc gattgaaaag ccgacatcgt 1355161 taaatcaagg aatggagcgg caccttaccg gtattattaa gctcgaagac ctgatgatct 1355221 ttttgcctga ctatgaaaaa attatttatg acattgaatc agattcaggt gttgacacgt 1355281 ataatatgca taccgagggc ttcgatgaaa gaagaactga taaaaagctt atcattgtag 1355341 aggactcacc gcttttgatg cgcctcttgc aggatgaatt aaaagaagca gggtacaaca 1355401 atatcgcttc gtttgaaaat ggaaaagagg catatgaata cattatgaac cttgctgaaa 1355461 acgaaactga tttatcaaaa cagattgata tgatcatcac tgatattgaa atgccaaaaa 1355521 tggacggaca caggctcaca aagctgctga aggaaaatcc gaaaagctca gatgtgccgg 1355581 ttatgatttt ctcatcgtta attacggatg atctgcgtca ccgcggcgaa gttgtaggcg 1355641 cagatgagca aatcagcaag cctgagatca gtgatttgat taaaaaagtg gatacgtatg 1355701 ttattgaata aataaaaaca gccgttgcca gaaagaggca cggctgtttt tattttaaaa 1355761 gtaactctcg ccaagttttt taaagaccgg tttatggtaa gctggctgct ggcgatttgg 1355821 cactagcggc ttttctttca tgccgacata ttcttgcaat aggtgtttcg cttttgttaa 1355881 agacatttga gctttaggat ttcgatacga ttgattaagt gtacctaaat gcggaagatg 1355941 ttcgaagtct tctttagttg gaggcatgtg aaaatagtag tctccgattg agataagcac 1356001 gtccgattgc tgttggctga accttggatt ttttgaaaaa tgaagcccta ttttctttcc 1356061 tttaccttct ttgacaagct tttgcaaagc ccgttttttc agcagatata ggtatttagg 1356121 gttgggggcg gtttttgcat ggcggttcac agtgtaaact gcttttgaaa gattttctac 1356181 ggttggctgc agatctttcg tatatgcatg gtcgtccatt atttctctcc tttgctctta 1356241 tcaatttcta tatgtttaga ttatactttt ttaaagttga aatgcaaata ttgaatgtaa 1356301 aaatgcgctt ttttctaaga aaaaaagcgc atttttaacc tgcattatac agatcttgcc 1356361 ttctttttcg gctgttcttg aaatgcttcc tgaacattca cttccacagc ctgagcactg 1356421 tattttggca gtgcaataaa ataaaaaata aaaacgagca ggataataac acccatgccg 1356481 taataaagat aatcaatgtt tgaaacaaac ttagggaata acagcgcgac taagccgagt 1356541 gtcaaagatt gtgcaaacat cataaaaggg tcctgcatgc cgcttacacg tcccatcagt 1356601 tttggatgaa caatttttgg catccaccct ccgattgcaa tgttgatcgg tccgatacac 1356661 attcccagtg caaaagctgc cgcgtaatac acccataaaa tattggtgta gccgaggacg 1356721 aagatcagca aacctgcaat gaaaatcggt atcgacatta aaaagtgcgg cttcactttt 1356781 ttagagatga gcgtgccgat tacgcttcct gccagaagcc caaacccgag tgcgatcgta 1356841 aatacagacg tatgccactc ataacggtca ggcgccaatc catatttcat tgtaaacatc 1356901 ggcaatacgg cgaatcctcc attgacaaat ccaaaaatga agaagccaaa aataagagat 1356961 gccagcaatt tgttttttaa aatatagagg atgccttctc taaagtcatt tattgaatcc 1357021 ttaacagaag tctttctcca gctgaatgca ccgtttggct gtcgggcttc ttttggaatc 1357081 cggcagctgc ggatcagcag cccggaaatg ataaagctga caaaatcaag aataatggcg 1357141 ccttcaatac cgattgtgtt gtacataaac gcgcctatgc cgactccaaa caccataaaa 1357201 atgctaaaaa gcatctgatt aagccctgcc gctttcgcat aatgctcctt cggcagaatg 1357261 gcttgtacca aactgttttc tgccggaaag aaaaactttg ttacagcgct tctgataaat 1357321 aagatacaaa aaacaagagg aatattgccg gtaaataaag tgaaaaaaag cacgacagtc 1357381 aggcctgctc tgatccaatc acaattttct gccacctttt ttctatcaaa ccggtccgcg 1357441 acgactccca cgatcagaaa tacaaatatg gtcggaagag aatacatcag ctccgccaag 1357501 gtcgtatatg aaggctggct gctgaatcgg tccagcaaaa aaaaagcaaa ggccatgttg 1357561 cctactgtcg tgcccatttg agaagcgagt gctgcgaaaa atagacgaac aaaattacga 1357621 tttttaaata tatccataaa aacgctcctt accctaaagg tcccacttta tcatattata 1357681 aaccgcctgt ttttgaaaca aataagaaaa cattaccggt taatcgtgac tctcgttccg 1357741 tttggcacaa ttgaagcaag ttcgatcacg tctttgttat gcatgcgaat gcagccttta 1357801 gaaacagcct taccaatcga agcgggatta ttcgtcccat gtattccgta gtgctgcttt 1357861 gaaaggctca gccaataagc gccaaatggg ccgccgggat tgcgctggcg gttaataatg 1357921 taaaactcgc cagtaggcgt ttgcgttagt attttaccaa cggcgatggg ataggttttc 1357981 attacccgat tatttaggga cagcgtaagg gtcttcgctc cgattgagac tgcgatatga 1358041 tacggaattg tataagggtc cggcagtccg gggatgacta tggactgtcc cgcggtgagc 1358101 cctgcctgca gtgacggatt agcctggagt aatgcagccg tgctgattct gaaatcagcc 1358161 gcgatgctgt tcagtgtatc accttgcttc acctggtacg taagcagttt cctcatcctc 1358221 cttttttact tataagtatt gatgaggagc ccatcctgct acattaattt gtgcttttta 1358281 aggtgaagac agtgatttca ggcttggcaa gaaaccgcaa aggcagcctg gtcatcccga 1358341 ggcctcggtt tacgtaaata tgagtgctgc ccgtttgata cattccctct gtgtagactt 1358401 ttccatatgg aggcgtaata atcggtccgt aaaaaggcag ctgaatctgg ccgccgtgtg 1358461 tatggccgga aagctgaagg ttcacgggat aatctgttgt tttcaaggct gcatcaggtt 1358521 catggacgag aagaatggaa aaaagtctgt cgctcagcct tgaaagggtg ccttcataat 1358581 ctgggtttcc cagcattaag tcatcaagcg aagcaatctc gattttgctg ccatctgcga 1358641 gtgacaatgt ttgatagcca ttgcgatata ccgtgaaacc tccggccgtc atcaggcttt 1358701 tgtaaacggc agttccatag cctccgtgat catgattgcc gtaaatacaa agcttgccga 1358761 agggagcatt aagctttctc aataatggaa tgactgcctg gtggtgctgg tacgtatcag 1358821 gattatcaat aatatcacct gtaaaaacaa tgagatcagg tttagattca ttaattgtaa 1358881 gaatgacagt ttttaaatct tcgagagtaa agtaatcact caagtgtgca tcgctgaact 1358941 gcacgatttt aaaaccgtca aatccgtgcg ggatgagaga gctttttatt gtgtgttcgg 1359001 ttgtctcgat catatgcggc tcgagatacc tggcatagcc atatcccccg ccggccgtta 1359061 aagccccggc agcaagagcg ccgaacattc cttttagaaa ttgtcttctg gacatctttt 1359121 tcatttcaaa ccaaccttta atagagtttt tctattatat catctgtatc tgataaaaat 1359181 ctcatatgag catgtgctga cagaggcagg gatataatga tagaatatta ttgaatgaat 1359241 aatcattcac aattggaggg ataaacatgg aaaaaaaggc ggtaattatt accggcgggt 1359301 caagcggcat gggaaaagcg atggcaaaaa aacaggctga attagggtgg cacgttatgg 1359361 tgacagggag gaaccatgag gcacttgagg aaacaaaaaa agaaattcag acctttgagg 1359421 gacaggtcgc ttgttttcaa atggatgtcc gttccgattc cgccgcttca gacatgatta 1359481 aagaagcggt aaaagccttt ggccggcttg acgcgctgat taacaacgcg gccggaaact 1359541 ttatttgtcc ggcagaaaag ctgacgccca atggatggaa agccgttatt gagattgttt 1359601 taaacggcac atttttttgc agccaagcag cggcaaggca ttggattgac cagaagcagc 1359661 agggtgtcat tttaaatatg gcagccacgt acgcttgggg agcgggagcg ggggtcgttc 1359721 attccgctgc agccaaagcg ggggtattgt cattgacaag aacgctggcc gttgaatggg 1359781 ggagcaaata cggcattcgt acaaacgcga tagcccccgg accgattgaa cgaacaggcg 1359841 gtgcggagaa gctatttgaa tcggaaaaag cgatggcccg cacgatgaac agtgtgccgc 1359901 tcggccgatt gggcacaccg gaggaaatcg ccgctttggc agcgtttttg ctttctgatg 1359961 aagcatccta tataaacggg gattgtatca caatggacgg ggggcaatgg ctgaatcctt 1360021 atccgtttta atctgaatat ttataagtga atatttaagt tattaagaac ttttatgttc 1360081 gaatgtaata cctccacaat taaccttctt cctatccaat ttgataacac atagagcttt 1360141 atttgtttat gaggtgttgt gtcatacgta agccacctaa tatatgaaag gtatatttta 1360201 aaaggggaga cgaaatatga agaacttaga tttcaaataa aacattcata taattacttc 1360261 gttaactaaa aagagaaatt ataagaatga aaggtttcaa ggttacatca gattgggagg 1360321 aaggtaatat aatggacgag atggtattat taactcagga atggctcaat gaaacgtaca 1360381 aaggaaaaag tggctacaat tccattgagg aaaatgggaa aactggctgg aaaacaatgt 1360441 atgcattaac tagagcatta caactagaat tgggaattac acagacttcc gacagttttg 1360501 gtcctacaac tttaagaaag cttaaagaat taggcccgat ttctacgtca actaattcaa 1360561 aaaaaaatat tgtgaaaatt attcaaggtg ctctttattg taaaggttat ggtccaggtg 1360621 gattaacggg tacatttggt cagggaacga aagaggcgat agcagaaatg caattgcata 1360681 tggggctttc taaaacagac ggtgtagtaa cgcctaaggt gtttaaagct ttattaaaca 1360741 tggactctta tatcctttta aatggggcgt cagagaaagt tcgttcaata cagcaatggc 1360801 taaataataa atattacaat agagagaatt tctactttat gccctgtgat ggcctgtatt 1360861 caagggatac tcaaaagtct cttgtttatg caatacagta cgaggaaggg ttaagtgata 1360921 gtatagctaa tgggaatttt ggaccaacta ctcaaagatt gattcctgta ttaagaattg 1360981 gagaaacaga tgaaaaaaac agttttattc atttatttca agctgctcta atctttaatg 1361041 gctacaatgt tccttttgat ggagtatact ctgaatctgt aagatcaaaa gtaaaggctt 1361101 ttcagtcttt tgcaaaatta caacagagtg gtactgccga ctttcaaaca tgggcttcac 1361161 ttctagtaag tactggagac cccaatcgaa aaggagttgc ttgtgactca attactcaaa 1361221 ttacatcgga cagggcggag tcccttaaga gggcaggtta taagattgta gggcggtatc 1361281 taacaaatgc gccggggagt acactaaata aaaaaataca accaggtgaa ttagaaacta 1361341 tcttaaaatc aggtttaaat gtttttccga tttatcaaac ctatggggga gcaacaaatt 1361401 attttaataa agaacaagga aagaaagatg cgtttgctgc ttataaagca gcaaaagaat 1361461 acgggtttaa aaataacact gtaatatact ttgcagtaga ttatgatgca tatggtaacg 1361521 atttaaacaa caatattatt ccacacttcg aaggtataaa tgaaataatg aacggttttt 1361581 taggttcaac ttacaaaatt ggtatttatg cccctaggaa tgtatgtact atagtttcta 1361641 aaaaaggttt agcatttgca agttttgtaa gtggtatgtc tactggcttt agcggaaact 1361701 taggatatcc tttgccttac aattgggcgt ttgaccaaat ttcaacaatt actgttggaa 1361761 atggttctgg aatgattgaa attgataatg atatttgttc aggtttggat aatggagtta 1361821 ataccataaa tatagtgcct tcagagaata agaagttttt tgatcaaatt gatgttttat 1361881 atgaaactgc tgaaaaatat gctcaaatgc aaagcgactt aaataatggg gtaaaaaaaa 1361941 cacaattagc taatgagttg gttgcccagt atttaagaaa ggatgactac aaagggtgga 1362001 agtgggtccc taccgcaggc cagattgatc ctatttatcg tgaatgggca gtaaagcgct 1362061 aggggaagac ctagtaaatg gaattgttga tcctatatca aaaactgtca taggaacgca 1362121 gcatcttatg gcaacttata atgccattat ttatagtggt ggttactctc aaacactacg 1362181 agattttgct ggttggactg gagatctatt aacaacaata caggacatga aattacacgc 1362241 tcaagaattt aattcgcctt atgatgcggc tatgaaaata ataggtaata tgtatcaatt 1362301 tagcctagat gatttattta gtgatgtaga tgcaattaat ctagcgaata aaacatcagt 1362361 tggtgctaat gcacaacctc taaatatcgc aattagagat tattatagta ataatgactg 1362421 tatgaatagg ttcactcaat ttgtaaataa tagatttgat ggttcgttag acaaaatttt 1362481 ctctgaagca gagtattatt taaatacaaa ccttgaccca gttgttgttc caattaggtt 1362541 agcctttaaa cgtgcttttg atgttgagga ttatagtgaa gagattggaa aaataacagc 1362601 acaagcattt agagatgtta tcgagaaaaa aatgatatct gaataaactg caaaacaagc 1362661 gaacgttaaa actggtcgtt cgcttgtttt attttctatt taaatttatg atataatttt 1362721 taaagattaa ggagtgattc attgaagaaa ttgttaaaaa agttagttgt attattttta 1362781 agcagtttag ttatcatctt taatgtttgg tactttatta tttgtgcttt ttccccagag 1362841 tattatcaaa atacaaatct tacttctaat gaaataataa gatttgaaaa actataccac 1362901 atagattttc ctgatgaaac aaaatttatt aaagctagag agtatttggc tgggcccgga 1362961 ggagatacgt cagctgtatt atatgtgtct ctgccaacca agcgggtaga aaaagtttta 1363021 tctgattaca cgtatatgaa aataaactat actgacaatg tcggttcaat gtatggagtt 1363081 gacgtttcaa agagtgtcgc cggtttaaca actcttacat ttggcactta cgataaaaaa 1363141 ggaactttct ataatatgaa acatgatgat gattggatgt ataaaggcac tgactggaat 1363201 ctttactttt ggacagctgc tagttataat gctgttattt ttgtatttgt tttggttatt 1363261 gtgaaacaaa tgaataaaat tcttaattaa ccagtatgta gattgataat ctcaaaaaaa 1363321 ttttcctctt cttttaacat actccatacg acctactttt ccatactatg atttttttga 1363381 aatttgtggt gtagttataa ttgtgcgtat aatcagacaa agatagagaa gcaggtgata 1363441 acatgttgga tccacttgat attttaacga acattgatga tgtccttcca tattaccagg 1363501 cgatttttag tgccgaggag cagaaggttg tcggatatga ggtgcttgga cgaattttgg 1363561 cagattcaga aatccaaagt ctcgggccct tctttttaga tgcggggata cccgaagaat 1363621 ataaattaga ggttgataac agaattatcc gccaggctct tgaccgcttt ttagaggcgg 1363681 attctgatct gctgattttt atgaatcagg atgccaatct gctgatgctg gatcatggtg 1363741 aaagctttct ggagcttctg aaagaatatg aagcgaaggg aatcgaactc caccgttttg 1363801 tgcttgaaat tacagagcac aattttgaag gggatattga gcagctctac catatgcttg 1363861 catactatcg tacatacgga attaaaatcg cagttgacaa catcggaaaa gaaagcagca 1363921 acttggacag aatcgcgctg ctctcaccag atctgttaaa aatcgatttg caggcgctga 1363981 aagtgtcaca gccgtcaccg tcatatgagc atgtgctgta cagcatatct ttattagcaa 1364041 gaaaaatcgg tgcggcgctg ctgtatgaag acattgaggc gaacttccag cttcagtacg 1364101 cctggagaaa cggaggccgc tattttcagg gctattactt agtgtctcca tctgaaacgt 1364161 ttctagagag agatgtattg aaacaaagac ttaaaactga atttcaccaa tttatcacac 1364221 atgagaaaaa gaaactggag accgtctatg agcactctga acagttttac aaacgagtgc 1364281 atcaggctgt gacctctttg agaaaaaaca atctgtcttc tgatgatgac tttattaaaa 1364341 agctggcgga agagctgaca gattgcagct tcaggattta catgtgtgat gaagaaggcg 1364401 atcagctgac gggaaatgtg tttaagcaag atggagaatg gatttatcag ccggaatatg 1364461 cggaaaagaa ctggagctgg cgcccttatt ttctggagaa cattatgaga atgagaaatc 1364521 tcagaaaagg ttttttcagt gatctgtaca gtgatttgga aacaggtgaa atgatcagaa 1364581 cgttttcata tccgatggat gatcagatgt atttatttat agacttgcct tattcttatt 1364641 tatatgagca ggacggactg atttaacggc tgaaaggccg ttttttttat gaaatgaaaa 1364701 aaatatcaaa aaacgattga cattgatact gagaatcatt atcatttaat tatagagaga 1364761 agctactctc tgttccccaa cccctctatc agatcaagat ccgaaaaaac ttggcgctac 1364821 ccccgccaag ttttttattt gtcaaagcat aggacaatcc aatgaaacaa taaacctaac 1364881 tagtggtaaa cgtttaacac ggggagaaac attgagtgcc gaacacccct gacactgctg 1364941 cacgggtgag gaggaaaatt cgttctgaaa tgattatttc agttccgttg tttacctcta 1365001 tccagcatga ctcccattga ttatggccac gcgggacttc accataaaat tcaaaagaag 1365061 gttttgacaa agttgcaaaa aggcattctt aatgctgcca aagattcgaa aaaaattata 1365121 attatgtgca tgacattcaa aaaaagcctc aaactaaaga aaaatagttt ttttcacttt 1365181 ttttctttgc ttaaattcag cagtgaaaat gccatcctgt ccgactttat ggtatgatgc 1365241 tcaatagaac ttgtattata ataaatactt gttgatttga agttgctttt tgaaaggagt 1365301 ctttttttag aatgtcacaa ttaatgggta tcatcacacg gctgcaaagt ctgcaagaaa 1365361 cagcggaagc ggctaacgag ccaatgcagc gttatttcga agtgaatggt gagaaaatat 1365421 gcagtgttaa atatttcgaa aaaaatcaaa cgtttgaact gacggttttc caaaagggtg 1365481 aaaaacctaa cacatatccg tttgataata tcgacatggt ttccatcgaa atctttgaac 1365541 ttcttcagta agattcctga aataggggga acaagcttcc gcctttgcaa aagtaatcga 1365601 aataaacggt aaggaacata cttgtttcat ggttgtaaat ccttgaaaag gagtgtcgtg 1365661 atggctgatt cttttctgtt ttataatctt tcagaagcac agatgacctt tcaagatgtg 1365721 atggaacggc ttaaagcctt tgttcaaaag gacccccgtt cttcttatgt gttatcgatc 1365781 ggaaccgatt cacaggttta ccgcgattac acaaagttta ttaccgcatt gcatttgcat 1365841 cgtacaggca agggagcttg gggctgcttg aaaaatcata cagtcgacag acccatacat 1365901 agccttcggg agaagatttc gttagaaacg gcgtacagcc aagaaacggc cgctcatatt 1365961 cttgatggac acttaatgga tattaccgat ctgctcctgc cctttaccgg tgagggggcg 1366021 gatcttacct ttgaagttca cttggatatt gggaaaaaag ggcttacaaa agatctgatc 1366081 caagaaatga ctggacgtat tacctccatg gggattgagg ccaaaataaa gccggattca 1366141 tacactgcct tcagctatgc aaatcgtttc acaaaataat ttggctgaaa aagccaaggt 1366201 aaatgtcgaa ttatgcggtt gacgtttgtt atctgattac ttattctagc ggtagagctg 1366261 aaagtaagtt gtcttgcttt cagaggtatt cagtataaaa cagggggcct gattgcgaat 1366321 gagtcttatc ggtgaacgat ttacagaaga agaacaaaaa cttctgctga atatcctgat 1366381 caaccatgag tatgccatcg agctattaag cagtgagatc aacgatatag agacagggac 1366441 caaaaacgtt gacggaacca cctacaaaaa acttgtaacg ctatacgacc gatttcgatt 1366501 tgaaaattaa tgggacaccc tataattgat actccacaaa gagtatcttt tttattgaaa 1366561 ggaaactttt cgacaaatac tgataaagtt tatattattg caatataggg aatgtattga 1366621 tgatgaaaat gaaaaggggt cgaaaacatg ataagcttac aatcagatca acttcttgag 1366681 gcaacagtcg gacaatttat gattgaggcg gacaaagtag cgcacgtgca agtcggaaat 1366741 aaccttgagc atgcattatt agtattgaca aaaaccggat acacagccat cccggttctg 1366801 gatccttcct accgtttaca tggcttaatc gggacaaata tgatcatgaa cagtattttt 1366861 ggacttgagc gaattgagtt tgaaaagctt gaccaaatca ctgttgagga agtcatgctg 1366921 accgacattc cgcgccttca tatcaatgat ccgattatga agggattcgg catggtcatt 1366981 aataacggat ttgtctgtgt tgaaaatgac gagcaggtat ttgaagggat ttttacgaga 1367041 agagtcgttt taaaggaatt gaataagcat atacgctcat tgaataagta ggctgtacgg 1367101 tcctattttt attatatagg cagagtgaaa aaagaaagcg catacataat ttaaacgaga 1367161 atagggcttg aataagaaac taagatttta ttagaatggg agataagaaa aacttattga 1367221 taacaaaaag gaggacgaca tgcagcttca agagcttcat atgctcgtag ttttagctga 1367281 ggaattaaat atgagaaagg cggcagaacg gctttttgta tctcagccgg ctttatctca 1367341 gcgcttacaa accattgaaa aggcgtgggg aacaaaaatc tttttaagat ctcaaaaagg 1367401 attaacggta acgcccgccg gtgagaaaat cattcagttt gcgaatgatg tgacattaga 1367461 gcaggaaaga ataagagaaa atattgacga gcttgaaggt gaaattcacg gcacattgaa 1367521 gcttgccgtc gcctccataa tcggtcagca ttggctccct aaagtcctga agacgtatgt 1367581 ggaaaagtat ccgaatgcaa agatctcgct cataaccggg tggagcagcg aaatgctgaa 1367641 aagcttgtat gaggatcagg ttcatatcgg cattataaga ggcaaccctg agtggaaggg 1367701 gcgcaaagat tacttaatga cagatcatct gtatttagtg gatactgaaa tttcctgcat 1367761 cgaagatatt gcccatacag aacgtccgtt tatccagttt aaaagtgaca gcacttattt 1367821 tcaggaaatt cagcactggt ggcatcaaaa atttaaaacg tcgccgaaac agacgatatt 1367881 ggttgatcag attgaaacgt gcaaacagat ggcgctgcac ggaatcggtt atgccatttt 1367941 gccgtctgtt acccttcaaa atgaagataa agtgaataaa atgcctcttt tagacatgaa 1368001 agggcatccg atcggtcggg atacatggtt attaggttat gagcctgcct ttgaactgaa 1368061 acaagttcaa gcttttgtac aagtgataaa ggatatgctg gatcaggaaa atccatttta 1368121 aagacagcga ggtgctgtct tttttttatt tatctgttga caatgaaaat cattatcatt 1368181 taaagtgata catatgatat tgaaaatcat tatcaactaa tggggtgata acatggctaa 1368241 agccttgatt acatatgcca gcatgtcagg aaatacagaa gacattgcct tcataataaa 1368301 agatacgctt caggaatatg agttggatat cgattgtgtc gagataaatg atatggatgc 1368361 gtcttgttta acctcctatg attatgtact gattggcacc tatacatggg gggacggcga 1368421 tttgccctac gaagcggagg attttttcga agaggtcaaa cagattcagc ttaatggttt 1368481 aaaaacagcc tgcttcgggt ctggcgatta ttcttatcca aagttttgcg aagcggtgaa 1368541 tttgttcaat gtcatgctgc aagaggcggg agctgctgtt taccaggaaa cactaaaaat 1368601 tgaattagcg cctgaaacag atgaagatgt ggaaagctgc cgagcgtttg cgagaggttt 1368661 tcttgcatgg gcagattata tgaacaagga aaaaatccat gtttcataaa ggggcaaccg 1368721 ctgttacggc atcggcgttt tctggatatt ttgtggcggt acaaagagaa ggcatttttc 1368781 attactcttt ggagcagggc tggagaaagc tttttcgttt gaaaagtaag atacactgta 1368841 tcagctacat agggccttac ttatttggcg ttggtgaaaa gggaacagtc attcgttcgg 1368901 ctgatgaagg gaaaacctgg acgatgtcga gctttccgac aaatgcaaca gtgtgggcga 1368961 ttaccggcag aaacaacggg tttgtctgcg cccacggtaa gcattgtatt tatgtatcgg 1369021 atgattttgg tgtctcatgg cgcgtagcca aaccttttgc cgaatttcat aatccccctg 1369081 ttatccggtc gttatgcctt cacgggggca atctctttat cggcacgcaa atacacgaat 1369141 attttggcgg catttgggct tacgacatta agcgtgacac tgtccaagtt gtcaaaaaag 1369201 aaaaaaaccg gatgacggca tccatgctcg tgttcaatga aaattggctg gtggcggcga 1369261 tgggttctgt gaaaggaaag cacggtgctg tcactgtaag gaatcttttg aatggtgaag 1369321 aattcaccat acaatccagt atgatcagaa atgaagaatc atttcttgat ctttcagagg 1369381 atgatggcat tatatatgtc actacaacac aagatgaaaa tggtttttcg agaatttacc 1369441 aggttgatct cgaagcccgg tcgttaaaat ggttcgatac cattaaggga catggatgga 1369501 gagtggccaa tcagaaagag aatttctttt gcgcaggctt gtatgaatgt aaatttgtcc 1369561 agccgtacga agtttcagca atgattcatt agaggaggaa caaggaattg gcgaagattt 1369621 tgctcgttta tgcaacaatg tcaggcaaca ctgaagctat ggcagatttg attgaaaagg 1369681 ggcttcagga ggcgttagca gaagtagacc gtttcgaagc aatggatatt gatgatgccc 1369741 agctgtttac cgattatgac catgtcataa tgggaaccta cacgtgggga gacggagatc 1369801 tgcctgatga atttttagat cttgttgaag acatggagga gattgatttt tccggcaaaa 1369861 catgcgctgt attcggttcc ggtgatacag catatgaatt tttctgcgga gcggttgata 1369921 cgctagaggc aaaaataaaa gaacgcggtg gagacattgt gctgccttcg gtaaaaatcg 1369981 aaaataatcc agaaggtgaa gaagaggaag aattaataaa cttcgggaga caattcgcaa 1370041 agaaaagcgg gtgcgctgtc tgatcactca ctgggaactg ctaaaacggc tgttcctttt 1370101 tttcttgtct ttgtatcttt cctttgatac agtaatgagg tagaaaatca ggaggaggac 1370161 tatacatatg aaaatgatgg acgcaaatga aattatttca tttattcaaa atagtacaaa 1370221 atctacacct gtaaaggttt acgtgaaagg tgagctggaa ggaatcaatt tcggtgaatc 1370281 tgcgaaagct tttatcaatg gaaacactgg tgtcgttttc ggtgaatgga gcgaaatcca 1370341 aacagcaatc gaagaaaacc aaagcaaaat cgaagactat gtggttgaaa atgaccgccg 1370401 caattctgcg atcccaatgc ttgatcttaa aaacatcaaa gcgcgtatcg agccgggtgc 1370461 gatcatccgc gaccaagttg aaatcggtga taacgcagtc atcatgatgg gtgcttctat 1370521 taatatcggt tcagtcatcg gcgaaggcac aatgattgat atgaacgttg tgcttggcgg 1370581 acgagctact gttggaaaaa actgccatat cggcgcgggt tctgtacttg cgggcgttat 1370641 tgagccgcca tccgctaaac cggttgtgat tgaagacgac gtcgtaatcg gcgcaaatgc 1370701 tgttgtgctt gaaggtgtaa cagtaggtaa aggagctgtt gttgctgcgg gagcgatcgt 1370761 ggtaaacgac gttgagccat acactgtcgt tgcaggcaca ccagctaaaa aaatcaaaga 1370821 cattgatgaa aaaacaaaag gcaaaactga aatcaagcag gaattacgcc agctgtaagg 1370881 aaaagtttga taaaaaaggc gtggataata tatccacgcc ttattcgtat aggcaggagg 1370941 aatagaaatg aagatagagg agctcatcgc aattcgcaga gatctgcatc gtataccgga 1371001 gcttggattt caggagttca aaacccagca gtatttatta aatgtcttgg aacaatatcc 1371061 gcaagacaga attgaaattg agaaatggcg aacagggctt tttgtaaaag tgaacgggac 1371121 ggcgccggaa aaaatgctgg catacagagc ggatatcgat gcgctttcta tagaagagca 1371181 aactggtctt ccattcgcat cagagcatca cggcaacatg cacgcctgcg gtcacgattt 1371241 gcatatgaca attgcactcg gcattattga tcattttgtt caccacccag tcaaacatga 1371301 tttgcttttt ctgtttcagc cggcagagga agggcctggc ggtgcggaac caatgcttga 1371361 gagcgatgta ttaaaaaaat ggcagcctga tttcatcact gcccttcata ttgctccaga 1371421 gcttccggta ggcaccattg cgacaaaaag cggccttcta tttgcgaata catcagagct 1371481 agtcatcgat ctggaaggca aagggggaca tgcggcatat ccgcatttgg ctgaggatat 1371541 ggttgtagca gcaagtacac ttgtcaccca gctgcaaacg attatctcta gaaacacaga 1371601 tccgctagac agtgctgtta ttacagttgg taccattacc ggaggctcgg cacaaaatat 1371661 cattgcagaa acggcccacc tggaaggcac gatccgcacg ctttctgaag aatcgatgaa 1371721 acaagtaaag gaacggattg aagatgtagt gaaaggaatc gaaatcggat tccgctgcaa 1371781 aggaaaagtg acatatccgt ctgtatatca ccaagtttac aatacgagcg gattaacaga 1371841 agaatttatg tcttttgttg ctgaacatca actggcgaca gtaattgaag caaaagaagc 1371901 aatgactgga gaggattttg gctatatgct gaaaaaatat cccggattca tgttctggct 1371961 cggcgctgat tctgaacatg ggcttcatca tgctaagctg aatcccgatg aaaatgcgat 1372021 agaaacagcg gttcatgtca tgacaggtta tttttctgtt tatgccaatt aagtacaaat 1372081 gaaagaataa aattccataa aatgagcact ctagtaaacg gaggtgttca aaaatggcta 1372141 aaaaaattgg aattgaacaa tcgttatcag atgtagaagc tgctttaaaa gaaaaaggat 1372201 atgacgttgt aatgatgaaa agccctgctg atgctcaagg ctgtgactgc tgtgtcgtaa 1372261 caggtcttga taataatgtg caagggatag ccgatacggt aacacaagca cctgtcatta 1372321 cagcttccgg gatgacggct gaagaaattt gtagcgaagt tgagagcaga attcagtaat 1372381 aaaaaaaccg aagcaaaaag cttcggttct tttatttatt ctgtttcttt agggaaagcg 1372441 cggtcgaacg cgttctttat ttcttttctc aacactcgtt cgactcgcca ctgttccata 1372501 ttttctgttt tggcaatgac cctgattaca atttcagaag tccccagttc ttgaatcccg 1372561 atgacatttg ggccttcttt tatttgtgga agagccgctg ccgtttcatc acaaacctgc 1372621 tgtaaaatat gaatcatttc atcaatattt ctttcagccg gcactttaat gtcaacaaga 1372681 gcctgcatgg taccacgaga atgattgctc acgtttgtga tgtttctgtt ggggatgtaa 1372741 tgcagtgttc cgtcaaagct gcggatttga gttgtcctta agccaacctg ctcgacaatt 1372801 ccgtcaaagg tggaaacggt aatataatct ccgacatcca attgtttctc aagcaaaata 1372861 aaaaaacctg tcacgatatc actgacaagc ccttgggcgc caaatccgac agccaggccg 1372921 acgattcctg cccccgctaa aagagcgctt ggatcataat gaaacaaatc tagaaccatg 1372981 acgaaaaata tgaaaatcaa tgtataagca aatatgttaa gagtcaggct tcggagcgta 1373041 tgtgcacgtc cgatagacaa gctattctgc tcctcgaatt ttgcaaacag atgtttaatg 1373101 attttcatgc ctaatgatcg aacgataaaa tagagcaata tcataatggc gagtttaatg 1373161 agcagaacac cggcatttgt aatcagtccc gcccaatcat attgtttaat aaagtccatg 1373221 ttgagctcct tttctaattg attgctgcac attgagacta gttaccctgt acatgaccat 1373281 gttaaacgtt ttattcaaaa atgtcgaagc caaagacata catgatttgt taaaaattga 1373341 ctcaggaaat ctgcttttat ataatggcat tgcaatataa ctaaaaatgg ttaatcaccc 1373401 tttattttca tgcgattttg acctttaagc caaacaataa attggaggga tacatatggc 1373461 agaacgtatg gtaggtaaac aagctcctcg ttttgaaatg gaagcagtcc ttgcaagcaa 1373521 agaattcggc aaagtaagtc ttgaggaaaa catgaaaaac gacaaatgga cagtgctgtt 1373581 cttctatcca atggacttca cttttgtttg tccgacagaa attacagcaa tgtctgaccg 1373641 ctatgacgag ttcgaagatc ttgatgcaga agtcatcggg gtttcaactg ataccatcca 1373701 tactcattta gcttggatca atacagaccg caaagaaaac ggtcttggcc agctgaaata 1373761 cccgcttgct gctgatacaa accatgaggt atcccgggaa tatggcgttt taatcgaaga 1373821 agaaggtgtg gctttgcgcg gattgtttat tattaatcct gaaggggagc ttcaatatca 1373881 aactgttttc cataacaaca ttgggcgtga tgttgatgaa acgcttcgtg ttctccaggc 1373941 gctgcaaact ggcggactct gtccggctaa ctggaaacca ggccaaaaaa cactttaatt 1374001 ctttccaaga acgaaaagcg gtctagcata ttcgttaggc ctctctttta aaataggagg 1374061 gaaaaagcaa tgaaattacg tcagcccatg ccggaattga cgggagaaaa agcttggtta 1374121 aatggtgaag tgacgagaga gcaattgatt ggggaaaagc cgacgcttat tcatttctgg 1374181 tccatcagct gccacttgtg caaagaagcg atgccgcaag tgaatgaatt tcgtgataaa 1374241 tatcaagatc agctgaatgt tgtagctgta cacatgcccc gttccgaaga tgatcttgac 1374301 cctggtaaaa ttaaagaaac agctgctgaa cacgatatca ctcagccgat ttttgttgac 1374361 agtgaccatg ctttaaccga tgcatttgaa aatgaatatg tacctgcata ttatgtgttt 1374421 gataaaacag gacagctccg tcacttccaa gccggcggga gcggtatgaa aatgcttgaa 1374481 aaacgtgtga accgcgttct ggctgaaacg gaataggtat ctgactaaat agtatttcct 1374541 aaaaacctga cctcatcagg ttttttattt gtgcaaaaag caatggaaga agagtaagaa 1374601 gcttattttt ccaaatttgg gtataggaat tgatgatttg tttgattgat acgctaaaaa 1374661 acacagctaa tttttgatgt ttttcctcaa ttttagataa atctcatatc tcataactcg 1374721 aaaattgtag atattacact aaatttcttt aaagaagtaa gtaaaatata tattttcaac 1374781 attataccaa ataaactaga aagcccctta atcccttgag aataaaggac tcttttgaaa 1374841 aataaaacat tttcagaaaa taaggaattt ttcatagagt aaatataata gtaaaatgct 1374901 aaaataatag ttgataaaat tacttttgta atctaatatc ttaattaaag atgttaattt 1374961 tgataggggg tacattgagg aatgtttaat gaaagagaag ctttgcgctt gcggttagaa 1375021 caattaaatg aagctgaagt gaaagtcatt cgtgaatatc aaattgaacg tgataaaata 1375081 tacgcaaaat taagagagct ggacagaaat ggaagccctt ccgaaatcaa aaaggatttc 1375141 cgttctgaaa aaaaacctga ctctctgccg gttctcgctg agcttgcggc tcaggaaatc 1375201 agaagctatc agccgcaatc acagcagcag tctgttcagc ctcagcttca atctatttcc 1375261 tctcttcctg ccggtatacc agacggaaca acacgaagaa gaagaggaac ggcaagaccg 1375321 ggatcaaaag cagctaagct gcgtgaagct gctattaaaa cattaaaacg ccacaacgcg 1375381 gcgattaaga gctcggagct tcaaaaagag attgaaaaag aaagcggtct tgaaatccct 1375441 aatatgacaa cgtttatgca aagcttaatt aaaatgtacc cggaagtgaa aaagccatat 1375501 cgcgggcagt acattttaga gggtgaaatc gaatctgcag aatcagcaaa cgaataaata 1375561 taaagaaaaa ctgcttggca tcgctcaagc agttttttta ttgaggtttt ttctgtgaag 1375621 gtttgttttc tttttcaaga ttaagcttat acacccactt ttgataaggc ttttcttcag 1375681 cggctctgtt tttcagctct tcgattgtat ggctcttggc ctggtctgat gattgggcgt 1375741 gggcaagctg tttttgaagc acatgtatct gtttggtgac atcttcaagg atagtctcta 1375801 catgatttgg ctgcgcgtag gccgctggag cttcttcttc cgttttttct ttttgtttcg 1375861 tgccgccatc aatatcggca aaatgagaag caatccaggc atcgctttca tcaagttgcc 1375921 gtttatacga tataatagtt tcgtgaaata atttttcttt cgttttttct atgtctagca 1375981 gtctttcttt cgtttctatg attcgatctt tcatatgatc aacttctatt ttaatatgtt 1376041 ttagctgata ttctttttct accatttgct cttttagacg cccgttttcg gcttttatca 1376101 attcggcttg ctgttttgcc tgaagcagtg cattttgttc ctgctcaatt gaggcttgaa 1376161 gttcgctgat ccgtttatga agatttttat tttcttcttc gattttgact ttcgcaatat 1376221 gaagtttatg tttttcttcg atttcggctc tgcgtttata ggtttcagca gatagaagct 1376281 cctgcaaaac aacgatttta tcaagcagtt cagctcttat ttggtgcagg gtttggctgg 1376341 tgtgggaggc atgtttttct tttgttgaca tatgtgttaa ttcggcagac agctgctgga 1376401 gtttttcttt catatcggta ttttctttga gcagtttgtt atttttctga tgaaagtagc 1376461 ttgcttcaag ttcagaaatc agcttatggc accttgaaag ctcggatttt aaataaaggt 1376521 tctcctgaga cacgtcgtgg aaaaaaggac ctgatctttt cattcgaacc atctccctca 1376581 tgatgttaac actacaatat gcaaatactg aacagctatt cctctttaat aaacagacaa 1376641 gcagtagcgt tgagcctttg cttttgctat gcttttaacg aaactagagg tgagatgata 1376701 tgaagcatgt aaacgtactg ctggcagggg gagcctcacg tcgctttgga gaaccgaagg 1376761 cgtttgtcaa atggaagggc aggatgcttt acgaatgcgc taaagaggca cttggagaac 1376821 aaacggttat catcagccgt cccgaattta ttgatagatt tcaagaaaac ggtgaaaatg 1376881 aagtgtatca agatgctgag ccatttcaag gcatggggcc attggctggt atatataccg 1376941 cttttaaaaa gacagacggt gatctttata ctgttctttc ctgtgacaca ccgctgatac 1377001 aaagaaggac gatgctggag ctcaaacgtc tgatgattgc cggtgcggac gcggtagtcc 1377061 caatttcaga cggacaagtg cagccattga ttgcgattta ccacaaacgt atcatgccag 1377121 ttctatacga tcagctttct gagaagaggt tgagaatatc agatttatta ggcagaattt 1377181 cggtttgtta cgtacaggct gaaaatatcg gagcaaaccc ggcagagttt atcaacatta 1377241 atacacgtga tgattttagc tgtttggaag aaaaatcgaa ctccctcaag cgggactgac 1377301 ggggcaataa catgataaga tgacataaaa gataaggaga acaggtttga tggaggaacg 1377361 ttattcacgg caaatcagat ttaagcaaat tggggaagag ggccagaaaa gactggcaga 1377421 cagccatgtg ctgattgtcg gagcgggagc gctcggcact gcaggagctg aagggctttc 1377481 gagagcggga gtcggtacga ttaccattat tgaccgtgac tatgtggagt ggagcaatct 1377541 tcaaaggcag cagctttata cagaaagcga tgccaaactc cgcatgccga aagccatggc 1377601 tgccaaagag catctatcag cgattaacag cgagatacat attgaggcgt atgttaccga 1377661 aggaacagcc gaaacgcttg agccgctgat tgaaaaagca gatgtcgtga tcgacgcgac 1377721 agataatttt gaaacccgca tgctgataaa cgatcttgcc cagaaaacaa agacaccttg 1377781 ggtctatggc gcctgtgtaa gcagccaggg aatgttcatg actgtcattc ccggagaaac 1377841 cccttgtctg tcttgtttgt ttgagcaaat tcctgtcggc ggggcgacgt gtgatactgc 1377901 cggcattatt ccgcctgctg tgcatatcgt ttcagcatat cagcaggctg aggcattaaa 1377961 gctgttaacc ggccaaaaag aagcaataca gcgggggttt gtgacatttg atgtctggaa 1378021 caattcgcat atgaagatta acgttaatca tgtacgccgt gaggaatgcc catcttgcgg 1378081 agctaatgcg gtatatcctt atcttcagga ttggaacaca ccaaaagctg ctgtactatg 1378141 cggccgtgat acagtgcagg taaggtcaga atcattaaaa agaatcccga aacaggagct 1378201 cattaagcgg ctgaaaacaa tcggcaaggt cgaggctaat gcgtttttgc tgcatatttt 1378261 ttacgaggat ttcagaattg tcattttcaa tgacggacgg gcactggtgc atggaacaaa 1378321 tgatgtgaaa gaagccaact ccgtgttggc aagagtgatt ggactgtaac aacaggaggg 1378381 gtcagaatgc tggagaaaag aacaccgata ccggtagacg aggcagttcg gcgtgtctgc 1378441 cattttcaaa aacaaggtga aacagaatgg gtggcgcttg aagacagcct tcatcggttt 1378501 ttagccgaag atataactgc ggatcaccac gtacctgcgt ttgaccgttc gccatacgat 1378561 ggttttgctg tcagagcgtg cgatacggca gaagcttcac gtgaaaaccc agttcggttt 1378621 gaagttattg accatattgg agcgggagca gtatctgaaa aagaacttgg cccgtttcag 1378681 gccgtgcgga ttatgactgg cgcgcaaatc cctgaagggg cagatgcagt cgtcatgatt 1378741 gaactgactc aagcctttga ggagaatggg aagtcattta tgtctttaaa acgccgcttt 1378801 cagacggggg ataatatttc aaaaacaggt gaggacgctc aaaaagggag tgttttactg 1378861 acaaagggca cccgggtgac accaggagtg acggctcttt tggcaacatt cggatacgca 1378921 tctgtgcctg tcgtgagaaa gcctgtagtc gggattatcg caaccggtac cgaattgctg 1378981 aatgtcagtg atccgctgga accgggaaaa atccgcaaca gcaatgcgag tatggtatat 1379041 gcgcaagcga tagaagcagg cgcaacaccg ctttatttag ggaaaatctc tgatgaactg 1379101 gataaaagct ttgctgcagt taaagaagcg atgaaaaagg tggacttcct gatcacaact 1379161 ggcggtgtgt cagtcggtga ctttgacttt ttgcctgcga tctatgaaaa actcggagcg 1379221 gacgtgctgt ttaataaagt tgccatgcgc ccgggcagcg tgacaacggt ggcgcatgca 1379281 aacgatatgc tgctgtttgg cctttcaggt aatccgtcgg catgctatgt cggttttgaa 1379341 ctgtttgtca aaccgataat ccagacatgg ctgctcaatg aaacaccgca ttcaatttgt 1379401 gcggaagctg ttttgaccaa ggattttccg aagccgaacc catttacccg atttgttcgt 1379461 gcgctcgtgc accatcagga agggaagctg ttggcgacac ccgttggctt agataagtcg 1379521 agctctgtca catcacttgc agatgccaat gcatttatta tcctgccggg cggtacgcga 1379581 ggctacgaat ctggcagaac ggttcaagtg ctgctcatca gagaagagaa tggaagtgaa 1379641 tggccttggt ccgtcctttc ccgatcgtcc aagttgtagg atttcaaaac agcgggaaaa 1379701 caacgtttat tgagcgcatt cttgaaaaag cctctgaaca gggagtccat ttgggctgcc 1379761 tgaagcacca tggtcacggc ggtgaaccgc aaacgctcac ggaaggaaaa gacacggacc 1379821 gttacaaggc ggcaggtgct gatgtaacag cggtagaagg tgctggtgtg ttacagctga 1379881 ctgcccgccg caattgggat ttggcacggc tgattgagtt ataccaattt ctcgaaacag 1379941 actgtcttct gattgaaggc tttaaaaaag ccccttatcc taaagtggtt atcctaagtg 1380001 aaaaggaaga tctggaagcg ctgcaagcag taaatataat cgccatcatc tatagaaaaa 1380061 aagagcatat gacagagcat cagggattac ccgtttttca tgcggatgat ccggttgccg 1380121 tggattttgt gctttcacag ctgaaggggg aatctgcata atggaacggt ttgagattac 1380181 gaaaacaccc attaatactg aaaacatcat caaaaaagtg gagaaacggg aagcgggagc 1380241 cattacaaca tttattggta cggttcggga atggacaaac ggaaaaagaa cggttcggct 1380301 tgaatatgag gcatatgaac cgatggccgt gcaaatgctt gctcaaatcg gcgctgaaat 1380361 cgaagaaaaa tgggaaggtg cctcagctgc gatcacgcac cgtataggtg tgctcgatat 1380421 cggtgaagca gcggtagtga ttgctgtatc ttctccccat cgaaaagccg catatgaagc 1380481 caatgagtat gcgattgaac gcattaaaca gattgtgccg atttggaaaa aagaaatttg 1380541 ggaagacggt gagcaatgga tcggcgacca gctagaaacg acagcttatc cgaacggaaa 1380601 accagaccta agcgagggag agcagcatga ttaaaattct tttatttgca gggcttgctg 1380661 aacaggccgg tacacaagca atagaaatag atatggaaca agcaaccaca gatgaaataa 1380721 aagcgagtct aaaagaacaa tacggtcttg aatctattga tacggctatg attgccgtta 1380781 acgaaagcta tgtaaaagaa aatacctctg tatcttcggg tgacacggta gccatcatac 1380841 cgccggtcag cgggggatga aaaccggacg gcatttcagc cgtccggttt ttctgtattt 1380901 cattggcata tccccaagta tcctcagcat acaatgattt tctgtaagcg tttattctac 1380961 atatgttact ccctataaag taagagactc actccataat tagactgaaa ttttgaaaaa 1381021 taatagaaat ttatttcggg tatcgatata gtgaagatga taaatgttgg aaaggtgctg 1381081 gatatggaga catttaaaag attaaaaatg tattattggc cgtacagaaa agtgtttatg 1381141 tggtcgcttc tagccatgct tttgatgact gcaattactg tcgtttatcc gattatcctg 1381201 caaattacga ttgatgagat cgtactggga cggcagtatc agcttgcggc gtgggtcagc 1381261 ttaggattta ttgcggtgat ggttttgaaa ggaatggcta ccttttttca tcagtattta 1381321 ggtgatatgt tcgggatcaa atccgtttat cggctgagaa atggtctgta tgaaaaactg 1381381 cagcggcttt ctttttctta ctatgataac gcgaaaacag gagatttgat gtccaggctg 1381441 actgctgatg ttgaagggct tcgttttttc ttatcatacg gtctcgctga gctcattcgc 1381501 ttcggcctgc tggtagccat cagcctgtcg gttatgtttt actattctgt tcctctcacg 1381561 cttgtgacaa tagctgttct gccatttctc gcggttgcgg tataccggtt tgacaaaaga 1381621 gtccatcccg ccttcagagg catccgcaaa tcgtttgcga aactcaatac aaaagttcag 1381681 gaaaatatca gcggcattaa tacggttaaa tctctttcca gggaagattt tcagatcagc 1381741 actttcaata aagccaatgc agaatacagg gcgcagtatt tacaaacatc atccatttgg 1381801 tctgcgtatt tccctttaat ggagttcatt ggtaacactt gtattgtagc tcttctctca 1381861 tacggcggtt acttggttat gcaaaatcag ctcaatcccg gcgagcttgt tgctttcttc 1381921 agccttgtca attatatgat gtggcccatt atgaacttag gttttgtcat caatatgttc 1381981 tctcaagcaa aagcgtcagg ggaacgcctg ctcgacattc tggaaaaaga agaagacatt 1382041 acagatcatc ctcatgcttt gcataaacaa aaattaaccg gagatgtcca tttcaaaaat 1382101 gtttctcttg catacggaaa agaacaaaca aacgcgctgt gcaatgtaag ctttgaggca 1382161 aacagcggga aggtaatcgg actgttgggc ccgacaggtt caggcaaaag ctcagtgaca 1382221 cagcttctca ccagatttta cagtcctgtt ggcggaatga ttaccattga tcacaaaccc 1382281 atcacagatt attcgttaaa aacccttcgc tccaatatcg gggtcgtact tcaagaatcc 1382341 ttcctgtttt catctacgat tagatcaaat atttcgtatg ggcggccgga tgcctcaatg 1382401 gaagacgtca tcgaagcggc aaaaagggcg caggctcata actttattat ggagcttcct 1382461 gatgggtatg acaccatgct gggagagagg ggaatggggc tttccggcgg gcagaaacag 1382521 cgtattgcca ttgcgagagc catctgcttg aacccgagca ttttaatatt ggatgatgcc 1382581 acaagcgcag tagatatgca aacggagcac agcatacagc ttgccttaaa agaagtcatg 1382641 aaaaaccgca caacctttat cgtcgctcac cgcatttctt cactgaaaca cgctgatgaa 1382701 attctcgttt ttaataaagg acgcattcgt gaaaggggaa cacatcatga gcttcttgaa 1382761 aaaggcggct actataaaaa gatttacgat ttgcaatacc gtgatgtcaa aatgattaat 1382821 gagccgcatg aggtcggata gggaggggcc aaatgaaaca agcgaaaaaa cagggggttt 1382881 tagagcgttt ctattactct tcagatgaaa tcattgaaaa gccgtttaac tgggctcaaa 1382941 tgtggcggct gctgagctat gtcaaaccat atcgaaaaac aattttgccg ctttcttttc 1383001 tcactgtatt gattggcact gctgtgaagc ttgtgatccc cattttgatc ggcgtttatg 1383061 ttcttgatca agcgattaca gggagaaact cggagctgct gattcagctc atttttatta 1383121 ttagcggttt atatgtcctc aattacgccg ccaatgtgtt aagaatcagg tggatgaatc 1383181 agcttggcca gcatgtcatt tacgatttgc gacagcattt atttacccat gtgcagcgct 1383241 tatcccatcg attttttgat cagcggtcgg cgggatcgat cttagtcagg atcatgaatg 1383301 atattaactc tcttcaggag ctctttacaa gcggagtcat caatttgttg accgacttgc 1383361 tgcttctggc cggcgtgatt attattttgt ttacgctgag ccctgagctg actatagcca 1383421 tcatggtgac attgccgatt atgtttttta tttcaacaag tctcagaaaa aaaatacgcc 1383481 gatcctggca aacggtacgg ctgaagcaat cgaagctcaa ctctcatcta aacgaaagca 1383541 ttcagggcat ccgggtcacg caggcattta cgcaggaaga agaaaacatg gcgtattttg 1383601 acggtgtcaa tcaggagaac tacgaatcat ggcgggaagc aactagaaaa aatgccatgt 1383661 tccgtccgct tgtagaaatg acgaatgcga ttgggacggc tgtcttgatt tggtatggag 1383721 ccacactcat catgaatgaa accattacga ttggcgtctt cgtttctttt gctttctatc 1383781 tgggaatgtt ttgggaacct atttcgagac tgggtcaggt ctataatcag ctgttaatgg 1383841 ggatggcatc atcagaacgg atttttgagt ttctggacga acagccaaat gtcaaggaga 1383901 agccgaatgc cattcataat gaaaagataa atggggagat cagttttgaa gaggttgaat 1383961 tttcgtatga tgaaaaacga aaagcccttc acgccgtttc tttctctatt cctgcgggat 1384021 cgacgcttgc gcttgtcggg catacaggga gcgggaagac gacgattgcc aatttaatca 1384081 gccgttttta tgatgcggcc ggaggcacca ttaaaataga cggtataccg attaaggatc 1384141 tttcccttgc cagtctgcgc tctcaaatca gcattgtcct gcaagataca tttattttct 1384201 ccgggaccat catggaaaat attcgttttg gaaggccaaa tgcttcggat gaagaggtga 1384261 tgaaagcgtc ccaagcggtc ggagcggatg agtttatttc cgatttagcg gaaggatacg 1384321 caacagaggt agaggaaagg ggcagcgtac tgtctgccgg tcagcgccag ctcatttcat 1384381 ttgcaagagc attgctcgcc gatccggcta ttatcatcct tgacgaagca acggcaagca 1384441 ttgatacaga gacagaagta aaaattcagc aagcgttaaa aacgcttctg aaagggcgta 1384501 cagcagtgat gatcgctcac agattgtcta cgatccgcga cgccgaccgc atcattgttc 1384561 ttgatcacgg caggaaaata gaagaaggga accatgatca gctgctcgct aaaggaggca 1384621 tttatgccgg gcttgtgaaa gcgcaataca gcacagcgat agaataatat gaaaagcctt 1384681 caatattgaa ggtttttgga aatttattag aaaaacatga aactttttga tatccttccc 1384741 gtactatttg ttagatattc tcaaggaggt tttgaaatgg aaacgaatgt agaaaaaaac 1384801 agcggaacgg cgactgaaaa gccttcactt ttcggagtaa tcacaagtcc gtccgttcaa 1384861 tttgaaagaa taagagaaag gccggctgta tggggaccgc ttttgattgt tgcagcaatt 1384921 atcatcgtcg gtgccgtgct gcaatcactc ggtacggatt atagtgagct tttgaaaagc 1384981 caggatacgc aagggctatc tgctgaacaa atggaaactg tcgcaacaat aaccaaattt 1385041 ggcggaatgg caggcgctat tatcggcggt atcgcagcat tatttattgc ccctcttatt 1385101 tattggctct gtgtaaaagt atcaggcggt gttacgacat ataaaaaaat gctttctctc 1385161 agtctgtttg tctctttgat tagcagtctc ggattattgg ttaatggaat cgttgctttt 1385221 acgactgacg tgaatcctct ttacagcacg acgtcactcg cagggattat cccatctgac 1385281 ggggctctcg ccagtgtgtt aaataccttt gaaattttca gcatctggag ctttgtatta 1385341 ttagcaatcg gacttcacaa aacgggaggc atctcaaaaa aagccgggtg gatttcagca 1385401 atcattctat tcggaatttt agttgtattt tcgctttttt caggtttaat caattctgtg 1385461 gcgggtgcat aagctcatga aaaaagtctg gatcggaatt ggaatcgcag ttatagtcgc 1385521 tctttttgtt ggaatcaata tataccggtc tgccgctccg acaagcggca gcgccggcaa 1385581 ggaggtacag acggggagcg ttgaagaaaa tgaaatctca tcaacggtta tggttcctgg 1385641 cacgctaaaa ttttcaaatg aacagtatgt cttttatgaa gcggataaag ggacattaga 1385701 agacattaaa gtaaaggaag gcgataaagt taaaaagggc acggctttag tcacctatac 1385761 aaatgagcag ctgagcctgg aaaaagaaca gaaccagtta acgtctgaat ccaaccggct 1385821 tcaaattgac caaattcaag aaaagttaaa agccttggac agcaaagaaa gagaactgga 1385881 aaaacaggta ggaaagaaag aagcagaaaa acaaatcgaa tctgaacgga cagagcttca 1385941 aatgcagaaa aaaacagcgg agatcgaatt aaaacaaacc gagcttcagc ggcagtcact 1386001 tgccaaccgg gtgtcagatt tagaagtgaa aagcgaaatt gaaggcaccg ttatttctgt 1386061 caaccaagaa gcggcatcca aaaagtcaga tattcaagag cctgtcatac atatcggcaa 1386121 cccaaaagac cttgtcgtct cagggaaatt gtctgaatac gatacattga aagtcaaaaa 1386181 aggccagaag gtcacactca cttcagatgt aatacagggt aaaacatgga aaggcacggt 1386241 ttccgcagtc gggcttgttc cggatcagca ggagagcgct gcggcacaag gaacagaaca 1386301 ggcggtccaa tacccgcttc aagtgaaaat aaaaggaaat cttccagaag gaaagccagg 1386361 ctttaaattt atcatgaata ttgaaacaga taaacggaaa gcaaatacgc ttccttcaaa 1386421 ggcagtcaaa aaagaagatg accaatatta tgtgtataca gtaaaagacg gaaaagcaaa 1386481 gcgagttgat gtcaaaatcg gcgaagtgac agatgacctg acagaaatta aagaggggct 1386541 tacccaagat gatcaagtca ttttgaatcc atctgatcag gtgactgacg gaatggaagt 1386601 gaaatcctaa atgattcagc tttctaatgt gcgaaaaagc taccagatcg gaaaggaaac 1386661 gtttgatgtt ctccattcta ttgatttgga cattcatcaa ggtgaatatg tctcgattat 1386721 ggggccgtca ggatcaggaa aatcgacgat catgaatatt atcggctgtc ttgatcggcc 1386781 gacttccggt acatatcaat tggacggcga agacatttct tcatataaag ataaagaact 1386841 ggcggcagtc cgtaaccggt ccatcggttt tgtatttcag caatttcagc ttcttccgcg 1386901 gctgaacgca aaaaaaaatg tcgagctgcc gatgatttat tccgggatag gcaaaaagga 1386961 acgtcaagag cgggctgaga gagcattgga aaaggtcggg ttagccgatc gaatgctcca 1387021 catgcccaac gagctgtcgg gcgggcagaa gcagcgggtg gcgattgcga gggcgatcgt 1387081 gaatgagccg aaattgattt tagctgatga accgaccggc gcgctggata cgaaaacaag 1387141 cgaggcgatt atggatcagt ttacagcatt aaatgccgag ggaacgacaa tcgttctggt 1387201 tactcacgag cctgaagtag cagattgcac gaatcggatc gtcatggtgc gtgacggaaa 1387261 cattgttcct gccagctccg gacaaaggag tgtgggagaa tgagcctgtt ggaaaacatc 1387321 agaatggctc taagctctgt ccttgcccat aaaatgcgtt cgatcttaac gatgctcggc 1387381 attatcattg gtgtaggctc tgtcattgtt gtcgttgcgg taggacaggg cggcgagcaa 1387441 atgctgaagc agtcgatcag cggcccggga aatactgtgg agctgtacta tatgcctagc 1387501 gacgaggagc ttgcaagcaa cccgaatgcc gcagctgaat ctacgtttac agaaaacgat 1387561 attaaaggtt taaaaggaat agaaggcatt aaacaagtcg ttgcttcgac ttctgaaagt 1387621 atgaaagcgc gttatcacga agaagaaacc gatgctacgg ttaacggaat aaatgatgga 1387681 tacatgaatg tcaattcttt gaaaatcgaa agcggcagaa cctttaccga caatgacttt 1387741 ctcgcgggga atagagtcgg aatcatctct caaaaaatgg ctaaagagct gtttgataaa 1387801 acctcccctc taggtgaagt tgtctggatt aacggacagc ccgttgaaat tatcggcgtg 1387861 ctgaaaaaag taacaggctt gctttctttc gatttaagtg aaatgtatgt gccatttaat 1387921 atgatgaaat cctcttttgg cacaagtgat ttcagtaacg tatcattgca ggtcgaatca 1387981 gcagacgaca taaaatcggc tggaaaagaa gcggcacagc tggtaaatga caatcatggc 1388041 acagaggatt cgtatcaagt gatgaacatg gaagagattg cggccggaat tggcaaagta 1388101 actgcaatta tgacgacgat tatcggctca attgcaggta tttccctttt ggtcggcgga 1388161 atcggtgtca tgaatattat gctcgtatca gtcacagaac ggacgcggga aatcggaatc 1388221 agaaaatcac ttggtgcgac gaggggacag attctgactc agtttttaat tgaatcagtc 1388281 gtattgacgc tgattggcgg tctggtcggg attggtattg gatacggagg ggccgcgctt 1388341 gtttcagcca ttgcgggctg gccgtcactc atatcctggc aggttgtatg cgggggcgtg 1388401 ctgttcagta tgctcattgg tgttattttc ggcatgcttc ctgcaaataa agccgcaaag 1388461 cttgatccca ttgaagcgct gcgttatgag tagcctcatg caacatgcat gaggtttttt 1388521 tatgtttagt gatttctact atgaatataa aagacttttt tcattaaaat aagaagaaaa 1388581 tgtcgtacaa ttgtccttat ttttgtcgaa tttacagttt acaaacccta tagacatacg 1388641 ttaatatgga gaaacgtgaa agattttgat agttattgaa tgaatttgaa tgattttagt 1388701 tgcctaaacc gaaaatagcg tttacaatga aattgtattc aaaatgaata cgttttcatt 1388761 aggaggtgaa gcatgctaac tcctgaacgg catcaattga ttattgatca aatagaaaag 1388821 catgatgtgg taaagattca agagcttata aatctgacta atgcttctga atcaacaatc 1388881 agaagagatt tatcgaccct tgaagaacgc ggttttttaa agcgcgttca tggtggagcg 1388941 gccaagcttt ccgatatcag acttgaaccc gatatgcttg aaaaatcatc caaaaacctt 1389001 cacgataaac tgaagattgc tgaaaaagct gcttctcttt tagaagaagg ggattgcatt 1389061 taccttgatg caggcacgac gacattgcac atgattgatt ttatggataa aaccaaagat 1389121 attgtcgttg tcacaaacgg ggtaatgcat atcgatgcat taataaggaa agaaatttct 1389181 ttttatctgc ttggaggata cgtaaagcac agaacgggcg cgattattgg aggcgcttca 1389241 ttggttgcca tggaccagta cagatttgac aagagttttc tggggacaaa cggtgtccat 1389301 acagaggctg gatttacaac gccggaccct gatgaggccc ttttaaaaca gaaagcgatc 1389361 aaacaggcaa aacacgctta cgtcttagca gacccttcga agttcggaga aatttcattt 1389421 tcggcattcg ccggaatagg cgacgcaaca atcattacga ctgacgctga agagcttaca 1389481 ttcgataatt accaagaaaa aactgtcgta aaggtagtga aaccatgatt tacactgtaa 1389541 cacttaatcc atctgtcgat tatatagttc acgttgaaga ttttactgta ggaggcctga 1389601 accgttcttc gtatgatacc aagtatccag ggggcaaagg catcaacgta tcgagactgc 1389661 tgaaaagaca ccatgtggcg tctaaagcgc tcggattcgt cggcggattt accggagaat 1389721 atatcaaaac atttttacgg gaagaaaacc tggaaacagc tttttctgaa gtaaaagggg 1389781 atacccgtat caatgtaaag ctgaaaacgg gtgatgaaac tgaaattaac gggcagggac 1389841 cgacaatttc ggatgaagat ttcaaagcct ttttagaaca gttccaatct ttgcaagagg 1389901 gagatatcgt tgttcttgca ggaagcattc catcttcact ccctcacgat acttatgaaa 1389961 aaatcgcaga ggcctgcaaa cagcagaacg cacgagttgt tctggatatc tcaggcgagg 1390021 ctcttttgaa agcaacagaa atgaaaccat ttttgatgaa gccaaatcat catgagcttg 1390081 gagaaatgtt cggcacggcc attacatctg ttgaggaagc cgttccttat gggaaaaagc 1390141 ttgtagaaca aggcgctgaa catgtaatcg tatcaatggc cggagacgga gcgcttctgt 1390201 ttacgaacga agctgtttat tttgctaacg tgccaaaggg gaaattggta aactcagtcg 1390261 gagcagggga ttccgttgtt gcaggtttcc ttgccggaat ttccaaacag ctgccgcttg 1390321 aagaagcatt ccgcttagga gttacttcag gcagtgctac cgcgttctct gaagaacttg 1390381 gaacagaaga atttgtccag cagcttcttc ctgaagttaa ggtcacacgt ctatagagga 1390441 ggaaacacaa gtgaaaataa ctgagctttt aacgaagcat acgataaagc ttaatattga 1390501 gagcaaagaa aaagaaaatg ttattgacga aatggtcact gttcttgata aggctggaaa 1390561 gttaaatgac cgacaagcct ataaagaagc cattttaaat cgcgaaagcc aaagctccac 1390621 gggtatcggt gaaggaatcg ctatccccca tgcgaaaacg gcaagcgtta tcaacccggc 1390681 gatcgcgttc ggacgttcaa aagacggcgt cgattatgaa tcattagacg gccagccggc 1390741 tcacttagtg ttcatgatcg cggcgactga aggcgcaaac aacactcacc ttgaagcatt 1390801 gtcaagactt tcaacgctgt taatgcgtga agaaatccgt aagcagctcc ttgaagctga 1390861 gtctgaagat gccatcatcg acattattaa tcagcacgat aaagatgatg acgaagagga 1390921 agaggaagaa gaagcggcac cagcacctgc cggaaaaggg aaaattttag cggttactgc 1390981 atgcccgaca ggtattgccc atacattcat ggctgcggat gcccttaaag aaaaagcgaa 1391041 agagcttggt gtggaaatta aggtcgaaac aaatgggtca agcggcatta agcacaagct 1391101 cactgcccaa gaaatcgaag atgcacctgc aatcattgtc gcagcggaca agcaggttga 1391161 aatggaacgt tttaaaggca agcgcgtact tcaagttcct gtaacggcgg gtatcagacg 1391221 tccgcaagag cttatcgaaa aagcgatgaa tcaagatgcg ccgatttatc aaggcagcgg 1391281 cggcggttca gcagcttcaa atgatgatga agaagcgaaa ggcaagtctg gaagcggtat 1391341 cggaaacacg ttttataagc acctgatgag cggtgtcagc aacatgcttc cgttcgtagt 1391401 cggcggcggt attctcgttg cgatttcatt cttctgggga attcactctg ctgatccgaa 1391461 tgatcctagc tacaacacgt ttgcagcagc attaaacttt atcggcggcg acaatgcatt 1391521 aaaactcatt gttgcagttc tggccggttt cattgcgatg agtattgcag atcgtcctgg 1391581 ttttgcgcct ggtatggtcg gcggatttat ggcaactcaa gcgaatgctg gattcttagg 1391641 cggcttaatt gccggattcc ttgccggtta tgtcgtgatt ttactgaaaa aagtatttac 1391701 gtttatccct cagtcacttg atggattaaa acctgttttg atttacccgc tgttcggtat 1391761 ttttatcact ggcgtattaa tgcaatttgt cgtcaataca cctgtagcgg catttatgaa 1391821 tttcttaaca aactggcttg aaagccttgg tactggaaac cttgtgttaa tgggtattat 1391881 cttgggcggc atgatggcga tcgatatggg cggtccgctt aataaagcag cctttacgtt 1391941 cggtatcgcc atgatcgatg caggcaacta tgcgcctcat gcagcaatca tggccggcgg 1392001 tatggttcct ccgcttggta tcgcacttgc aacaaccatt ttcagaaaca aattcactca 1392061 gcgtgaccgt gaagctggta ttacatgcta tttcatggga gctgctttcg taacagaggg 1392121 agcgatccca tttgctgcgg ctgatccgct tcgcgtcata ccagctgctg tagtcggtgc 1392181 agctgttgcc ggcggattaa ctgaattctt ccgagtaacg cttccggcgc ctcatggagg 1392241 agtattcgta gctttcatta caaaccatcc gatgctttac cttttaagta tcgtgatcgg 1392301 tgctgtcgtg atggcaatta tcctcggtat cgtcaaaaaa cctgttacag aaaaataaga 1392361 aaaaaagcgt ccttggttcg aaaggacgct ttttcttatc cggccggcag ggagcgcggt 1392421 taagttatgt attttattct tttttatgat aaagtaaaag aagagaaaca actgacatag 1392481 caattgtcta ggaggaaaca ctttgaccga ggaaaaaaat acgaatactg agaaaacggc 1392541 gaagaaaaaa accaatacgt acctggaatg gggtaaagcg attgtcatcg ctgttctgct 1392601 ggctctcctg atccgtcact ttttgtttga accgtattta gttgaaggtt catctatgta 1392661 tcccacatta catgacggag aaaggctgtt tgtgaataaa acagtcaact atatcggcga 1392721 gctgaagcgc ggagatatcg ttattatcaa cggtgaaact tctaaaatcc attatgtaaa 1392781 aagattgatc ggaaagcctg gagaaaccgt tcaaatgaag gatgacacgc tttatataaa 1392841 cggtaaaaaa gtagccgagc cttacttgtc taaaaacaag aaggaagcag aaaaacttgg 1392901 tgtcagtctg acaggagact ttggaccggt taaggttccg aaaggcaaat actttgtcat 1392961 gggagataac cggctgaatt ctatggacag ccgaaacggg ctgggactga tcgcggaaga 1393021 tcgaattgtc ggcacatcga agtttgtctt tttcccgttt aacgaaatgc gtcaaacaaa 1393081 ataaaaacgc cttgctggcc taggacagca ggcgttttta ttttgaaaaa gaagcgacca 1393141 atgcaatgca taaaaccgtg atgaacactg aaccgataat agccagcaca ctgaagaaaa 1393201 ggtgaacctg tttgttctct tttccgcgct tttctaatag ccgtttagaa aaaatgtgcg 1393261 aaaatatgta aataagggct atgcctatat ataagccgat atctttggcg gtaaagcctg 1393321 ttacggcaag gtaaaagccc gtaaaaaaga tcagtaagca atattcagta agtgttaaaa 1393381 gcctcaacgt gttcctccat gagagtgtgt aattttccag gcggatgcat tctctctctt 1393441 taattgtaac acagctggct ggtttgggtg tataagtgtt ttctctctgt tttatcaggg 1393501 aatcatttct cttgccctgc attcatggta tacttttatt gatgatagac atgatggagg 1393561 ataataaatg attgctgtaa ataatgtaag cttgcggttt gcggatcgca agttatttga 1393621 agatgttaat attaaattta ccccaggcaa ctgctatggg ttaattggtg caaacggtgc 1393681 cggtaaatca acgtttctaa aggtgctgtc aggcgaaatc gagcctcaga caggcgacgt 1393741 gcatatgagt cctggcgagc gtcttgccgt cttgaagcag aaccattttg agtacgaaga 1393801 gtatgaagtg ctgaaagtgg tcattatggg ccacaaacgc ctgtatgaag tcatgcagga 1393861 gaaagacgct atttacatga agcctgattt ctcagatgag gatgggattc gtgctgctga 1393921 gctagaaggt gaattcgcgg aactgaacgg ttgggaagcg gaaagtgaag ctgcgatcct 1393981 gttaaaaggc cttggtatct cagaagatct gcacacaaaa aagatggcag acctcggcgg 1394041 ttcggagaag gtaaaagttc tcttggcaca ggcattattc ggcaagccgg atgttctgct 1394101 gctcgatgag ccgacgaacc acctggacct tcaggcaatt cagtggcttg aagagtttct 1394161 gattaacttt gaaaacacag ttattgtcgt atcccatgac cgtcactttt taaataaagt 1394221 atgtacgcac attgccgacc ttgattttaa caaaattcaa atctatgtcg gaaactatga 1394281 tttctggtac gagtcaagcc agctggcgtt aaagctttct caagaagcga acaagaaaaa 1394341 agaagagcag attaaacagc ttcaagagtt tgtcgctaga ttcagcgcca atgcgtctaa 1394401 atctaagcag gctacatcaa gaaagaaact tctcgaaaaa atcacgctgg atgatattaa 1394461 accgtcttcc cgccgctatc cttatgttaa cttcacgccg gaacgggaaa tcggaaatga 1394521 tgttcttcgc gtggaaggct taacaaaaac aatcgatggc gtaaaggtgc ttgacaatgt 1394581 cagctttatt atgaatcgag aagataaaat tgctttcact ggccgaaatg aacttgctgt 1394641 tactacgctg tttaaaatca tttccgggga aatggaagct gacagcggaa cgtttaaatg 1394701 gggtgttacc acatctcaag cgtattttcc aaaagacaac agcgaatatt tcgaaggcag 1394761 tgatctgaac cttgtagact ggcttcgcca atattctccg cacgaccaaa gtgagagctt 1394821 tttacgcggt ttcttaggac gcatgctgtt ctctggagaa gaagtccaca aaaaagcaaa 1394881 tgtactttcc gggggagaaa aggtccgctg tatgctgtcg aaagcgatgc tttctggcgc 1394941 caatatttta attttggatg agccgaccaa ccatttagac ctagagtcca ttacagcgct 1395001 caataacggc ttaatcagct ttaaaggcgc tatgctgttt acttcccatg accatcagtt 1395061 tgtgcagacc attgccaaca gaattataga aattacacct aacggcatcg tcgataagca 1395121 aatgagctat gacgagttcc ttgaaaatgc tgatgtgcag aaaaaattga ctgaactata 1395181 cgccgaataa aaaagcagag atttctctgc tttttttgat acctaaatgt gaaaggagat 1395241 cacaacatga aatttttggt tgtcggagca ggtggagtag gcgggtatat tggcggacgg 1395301 ctttcggaga aaggaaatga tgtgacattt ctcgtgcgcc aaaaacgagc tgagcagctt 1395361 aaaaaaaccg ggcttgtcat ccatagtgaa aaagggaatg tatcatttca gcccgaacta 1395421 atcagtgccg gagaaacagg gcaatttgat gtcgttatca ttgcttctaa agcatactcg 1395481 cttggtcaag tgatagagga tgtcaaacca tttatccatc aagaatctgt cattatccct 1395541 tttttaaatg ggtaccgcca ctatgagcag ctatttgcgg cattttcaaa agaacaggtg 1395601 ctgggcggcc tgtgttttat agaaagtgct ttagacaaca aaggagaaat tcatcatacg 1395661 agcgcatcgc atcgttttgt atttggagaa tggaacggcg agcgtacgga gcggataaga 1395721 gcgcttgaag aggcattttc aggtgtgaag gctgaagtca tcattagcgg gcatatcgag 1395781 aaggacattt ggaaaaagta tctctttatt gcagcgcaag cggggatcac aacgttattt 1395841 caacgaccgc ttggcccaat cctcgccaca gaagccggac gtcacacggc ccaaactctt 1395901 attggggaaa tttgcactgt tttacgaaaa gaaggtgttc cggctgatcc ggctcttgag 1395961 gaagagagct ttcgtacgat gaccagcatg tcttaccata tgaagtcctc catgcttcgg 1396021 gatatggaaa acggccaaac gacagaaggc gaccacctgc atggattttt gattgaaaaa 1396081 gcaaaacgtt tatctctcgc tgcaccagta ttagaaaccg tttatgcgaa tctgcaaatg 1396141 tatgaagcag aaaaataaaa aaaggaggcg gaaaagcctc cttttattta cttaaaaagc 1396201 ccaatttccg tttctgaaga taggctctct tttcccgtct gccgtaattc cgtcaatatt 1396261 catatcctta gaaccgatca taaagtccac gtgtgtaatg ctttcattta ggccttcttt 1396321 gacaagctct tcacgagaca tctgctttcc gccttcaata ttaaaggcat aggcgcttcc 1396381 gatcgccaaa tgatttgacg cgttttcatc aaacagcgtg ttatagaaaa gaatgtttga 1396441 ttgtgatata ggcgaatcgt aaggaacaag tgccacttca cctaaatagt gagaaccttc 1396501 atctgtttcc accagttctt ttaaaatatc ctcacctttt tcagctttaa tgtcgactat 1396561 acggccattt tcaaacgtca gggtgaaatt ttcaataata tttccgccgt agcttaatgg 1396621 ttttgtgctt gataccactc cgtcaacccc gtctttttgc ggcagcgtga acacttcttc 1396681 tgtcggcata ttggccataa actcatggcc actttcattc acgcttcccg cacctgccca 1396741 aacatgcttc ctaggcagct taattgttag atcagttcct tctgcttgat aatgtaaggc 1396801 agcgtaatgt ctctcgttca aatggtcaac tttttcatga agattttggt catgattgat 1396861 ccacgcctga accgggttgt cttcatttac gcgcgtcgct ttaaaaattt cttcccacag 1396921 aaggtggatc gcttcctcct ctgatttgcc aggaaacacc ttgtgagccc agcctgctga 1396981 tgccgcacct acgacagtcc agctgacttt gtctgattga atatattgtc tgtatgtatg 1397041 taatgctttg cctgctgctt tttggaatgc cgcaatccgt ttggaatcta taccttttag 1397101 caagtctggg ttcgacgaca caacagaaat gaaagcagct ccatttttgg caagctcttc 1397161 tctgcctttt gcttcccatt caggatattc ttcaaatgct tcaaacggcg caagttcgta 1397221 ttttaatttg gcgacttcgt catcctgcca attcacggtg acgttttttg cgcccttttc 1397281 atatgcgtgt tttacaatta aacggacaaa atcccgaacg tctgttgaag catttacgac 1397341 tacatactgg cctttttgga cattaacgcc gacttctacc gccagctgtg catatgtatt 1397401 taatttctgt gaaaatgaat ccatgaatca ttcctccaag cttttttctc atcatatcaa 1397461 atatgatcct ataaaggaaa gaaggagccc aaagtgaaaa acccaaaacg acacgtcttg 1397521 ggttttttca atattatgga tgattcagtt ttacagtgcc gcctgcaggc gaatggggca 1397581 tatttgccaa agaaatgctc atgcctccaa gaataattcc gcttaaaatg gctgcgatcg 1397641 ctactcttct tcctaaatct cttagcatct gtttcctcct taacgtttct ccatttccca 1397701 caatatgaag gaagtgagga aaaaagaagc aagaaatttg ccgcgtgtga gaattttgcg 1397761 ggtaaagact atttaattgc cttttgcagc ttatcaatca cttctaaaga acggcctgtg 1397821 ccgattgcta cagattcaag cgggttttgc gccacgtgta caggcacgac aatctcttct 1397881 gtgagccatt ctttaattcc attaaggagc gcgccgccgc ctgttaaaat aacgccgcga 1397941 tcaacaatat ctccgctcaa ttcaggcgga cagtcctcaa gtgtcgctct gatggcttca 1398001 agaatatgca ggagggattc acgcattgca tcttgaattt cgttggattg aagcataatg 1398061 gtttttggaa gacctgtcac gaggtcacgt ccccgaattt ccattgcctc tggtatatgt 1398121 tcaatcagag catggccaat ttccattttt acctgctcag ctgtgcgttc gccgatcagc 1398181 aaattgtatt ttttacggac gaaagaaacg atatcctcat caagctggtc tccgccgatc 1398241 ctgatagaat ggcaggaaac aacgccaccg aaggaaataa tagcgacctc tgtcgtccct 1398301 ccgccgatat ctactaccac attggcaacc ggctcatcaa ccggtaaatc cgctccgatg 1398361 gcggctgcaa ctggctcttc gattaaatga acgtttttcg cgccgcaatt tttcaccgca 1398421 tcactgatgg cgcggcgttc tactgctgtt gagcctgatg gtgtgcaaac gactacgttc 1398481 ggttttctga acgacatgcc gatgcttttt gcggcttttt tcataatgtg ctttagcagg 1398541 tcagttgtca tatcatagtc tgcgatcacg ccatctttca tcggtctgac agcgacaatt 1398601 tttcccggtg ttttaccgat catgtttttc gcgtcagctc cgattgcaag cactgctttt 1398661 gtcgtcgtat ccactgcgac aacagatggt tcatttagga taatcccttt atttttgctg 1398721 taaacaagta tattagctgt tcctaagtca atcccgattt cagttgattg aaacatgttt 1398781 tcacccaatc tctatcctaa tttaatatga ttctacattt aaagtttctc agaaatactg 1398841 cgatttttgg gggtgtgcgt cggtaaagaa atgtttttgt aaaaaatcaa ggaactgtgt 1398901 aacagaagta atacattttt cggttttatg gaaaaaatat cttgtaattc ttatagaaag 1398961 cgggaaactt tttcaaagtt tcattcgtct acgatatatt gaggtacatc cttaaaacat 1399021 tacatgagaa aagaaacatt taaaggaaga agggttttta tgaaatcaat aggtgttgtg 1399081 agaaaagtag atgaattagg ccgcattgtc atgccgattg agttgagacg ggcattggat 1399141 attgccataa aagacagcat tgagtttttt gttgacggag ataaaattat cttgaaaaag 1399201 tacaaacctc atggcgtttg tttaatgact ggagaaatca cttcagaaaa taaagaatac 1399261 ggcaacggta aaattacgct aagccctgag ggtgcacagc tgcttctcga agaaattcaa 1399321 gccgctttaa aagaataaaa ttatgctaaa aaaggcggag tgatatcatc tccgcctttt 1399381 ttgcgtgcca atttttgatt accgccgcct aagataagac atcaagatat ttggtaatga 1399441 atgatttggg atactttaca tattttactc aattatttgt cgaagaatgg tacaataagt 1399501 agagaaacac aagcggcagg tggtcatatg agaaaatatc aagctcgtat catttccatc 1399561 attttggcaa tgatttttat aatgttttgg gattatttat tttattttat aggcaaaaac 1399621 ccgattaatt ggcctgttga tattgtgtat actgcagtca cgctggtaag tgtctggatg 1399681 ttggcttatt atattgatga gaaacagcag ctggttaaga aaatgaagga taacgaatgg 1399741 aagtataaac agctttctga agaaaaaaac cgcatcatgg ataatttgca ggaaatcgta 1399801 tttcaaacga atgcaaaagg tgaaattaca tatttaaacc aagcgtgggc atctataacc 1399861 gggttttcaa tcagtgaatg tatgggaaca atgtataacg attacttcat aaaagaaaag 1399921 cacgtagccg accacattaa cacccaaatc caaaacaaag cgtcttctgg catgtttacg 1399981 gcaaaatacg tgacaaaaaa cggcacgatt ttttggggag aagttcatta taaactttac 1400041 tatgaccggg atgaccaatt tacaggcagc ctgggtacaa tgtcagatat cactgagcgg 1400101 aaagaggctg aagatgagct cattgagatt aatgaacggc tggcgaggga atcccagaaa 1400161 ctatcaatca caagtgaact tgccgcaggt attgctcatg aggtcagaaa ccctttaaca 1400221 tctgtcagcg gtttcctcca gattatgaaa acacaatatc cggacagaaa agactatttt 1400281 gacatcatct tttcagagat taaaagaatc gatttagtgc tcagcgagct gctgctgctt 1400341 gcaaaaccgc aggcaatcac atttaaaaca caccagctta atgagatctt gaaacaagtc 1400401 acgacattgc ttgataccaa tgcaattctg tccaatatcg tcatagagaa aaatttcaaa 1400461 gagacagatg gctgtatgat taatggagac gaaaatcagc tgaagcaggt ctttatcaac 1400521 atcattaaaa acggaattga ggcaatgcca aagggcggtg tcgtaaccat ttcaactgct 1400581 aaaaccgcct ctcatgcagt gataagcgta aaggatgaag gaaacggcat gccgcaggaa 1400641 aagctgaagc agattggcaa acctttttat tcaacaaaag aaaagggcac tggactggga 1400701 cttcccattt gtttgagaat cctgaaggaa catgacgggg aattgaaaat cgaaagtgaa 1400761 gctggaaaag gcagcgtctt tcaagtggtt ttgcctttaa aatcagacag ctgagaggag 1400821 aaaaataaag tgaactcgct tctgtttgta tacgggacat taagaaagca tgaaaaaaac 1400881 catcatttgc tggcacaatc ggcatgtatc aatgagcagg cgagaacaaa gggaagtttg 1400941 tttgctgcaa aagaggggcc cacagttgtt ttcaatgatg aagatgaagg ctatatatat 1401001 ggcgaagtat atgaagcaga tgaattgtgt atacataagc tcgatcaatt ttttcaagga 1401061 tatcataaac aaacggtgtt tgtagaaacg gatgtcggga ttaaaattgc gcttatttat 1401121 tttatgaaca aagacgggtg tgccggtttt acgaaaataa gcagcggcga ctggaaagaa 1401181 catcagatga tcagcaaatc gaaaaatccc atttattatt ttgcctatgg atcatgcatg 1401241 gataatgccc gctttcaaaa agcgggagtc gatcactatt ttcaagatcc agtaggaaga 1401301 gctgttttaa aaggatacac aacccgcttc acgctaaaaa gggaagacgg ttcaagagcg 1401361 gacatgttgg aagacggagg aacaacagaa ggcgttttat accgtatccc ttattctgct 1401421 ctctcctatc tatataaaag ggagggcgtc gaatctctta cgtatcggcc ggcatttgta 1401481 gacgttgaag ctggcggaag gcactacaaa gactgtttaa cctttctcgt cctccaaaaa 1401541 gaagcggaaa ttgccccgcc tcagcactat cagattgaaa tcgaacgcgg agcggagctg 1401601 tatttgtcgc ctgagtttac tgaaaagctc aagcggcata tgaattcgct gccaaaagga 1401661 taacactgta acaaaagaat atgataaaat ttgatcaata tcatgtcata taaaggagca 1401721 ccacgatgaa aaaagaattt gcggtaattg ggctgggccg ttttggtggc agtatttgca 1401781 aagcattaag cgaagaaggc gtcgaggtta tggcaatgga tatcgatgaa gataaagtca 1401841 acgagtatgc caagattgca tctcacgcag ttatcggtga ttcgacagac gaatctgtcc 1401901 tgaaaaattt aggcctgcga aattttgacc acgttattgt agcaatcggg gaaaatattc 1401961 aagcgagtat tttaacgaca ctcattctga aagaacttgg cgtccatacg attacagtta 1402021 aagcgcagaa cgattatcac gaaaaagtgc tgtctaaaat tggtgcggat cacatcgtcc 1402081 acccggaacg cgatatggca aaacgaattg cgcataatat cgtgtccaac aatgtacttg 1402141 actatttgga gctgtctgaa gagcatagtc ttgttgaaat cgtagctaac agccgcctgg 1402201 ctggaaatac gcttctcgat ttagatattc gcgcaaaata cggtattaac atcgtagcca 1402261 taaaaagggg caaggaagtc atcgtatcac cgcttgcaac cgaagtcatc caccaagaag 1402321 atatactcat tgttattgga tcagttacag acatctcccg tttcgaaaaa agagttcttc 1402381 atacaaaata gcagccaaat aagccgtcct caaagggcgg tttttcatat tatcagaata 1402441 taacaacttt aatgaactga gcgtcaattt cttaaaattt cattgactaa gcacaggcgt 1402501 tccgatagca tattgtacca tataataaaa aaaggagggg cctatttgaa taaagaagcg 1402561 ctagtcaata ggctgaatgc ttcagccaaa agacaaaaag ctgatatcgt cattaaaaac 1402621 ggaaaaatca tggacgtata taatcaagaa tggatatatg aagatattgc gattacagat 1402681 ggagttattg taggcctcgg tgagtatgaa ggcgaaaata tcattgatgc agagggacaa 1402741 atgattgttc cgggttttat tgatggacat gtacatattg agtcgtcaat ggttacaccg 1402801 attgagttcg ctaaagcagt gttgcctcat ggcgtgacga cggttgttac agatccgcat 1402861 gagatcgcga atgtgtctgg tgaaaaaggg attgagttta tgcttgaaca agctcggcat 1402921 acaccgctga atatccattt tatgcttcct tccagtgtgc ctgccgcaag ttttgagcga 1402981 tcaggcgcaa ttctcaaagc tgccgatctc aagccttttt atgaagaaga agaagtatta 1403041 gggctggctg aagttatgga ttatgtgtcg gttcagcagg ctgaaaaaga catggttcag 1403101 aaactgcttg atgcccgtgt ggcaggaaaa aggatagacg gtcatttagc tggtttatca 1403161 acagacctca ttaacattta cagaaccgca tttgtcttaa acgaccatga agtaacatcg 1403221 aaggaagaag cccttgatcg tatcagaagg ggcatgtatg tcatgatgcg tgaaggatca 1403281 gtcgccaaaa acacgctcaa tgtgctgccg gcggtgaatg aaaagaacgc acgccggttc 1403341 tttttctgta cggatgataa gcatgtggat gatttattgt cagagggaag tgtaaaccat 1403401 caggtgaaaa tggcgattca agccggactt aatccgtttt tagcctatca gctaggaagc 1403461 ctcaatgcag ccgaatgcta cggattagat acaaagggag cgattgcccc gggttttgac 1403521 gctgatttgc tttttgtatc tgatctggaa aatgtcactg tcacaatgac gatggtaaaa 1403581 gggcagactg ttgctgaaga cagcaaagcg gtctatcagg atcatgcttc aactgcagca 1403641 ccagatcagg cactgcttga ttctgttaag cttgctgctc ctcttaacaa acaggatttt 1403701 catatgccaa tcgattcaga gcagcagatc aatgtcattc aaatcatacc aaatcagctt 1403761 gaaacacgat tagtacaagt tccggctcct gttgcccgcg aatttgagcc tgacactgag 1403821 cttgatttgt taaagattgc agttgtcgag cggcataaag gattaaaaga aaccggactt 1403881 ggtgttgtga aaggttttgg attcaagagc ggagcgattg ccacaaccat ttcacacgac 1403941 tcccataata ttattgccgt cggaacgaat gatgaggata tcgcggcggc agttaataag 1404001 ctgcaggaaa ttggcggagg attaacaatt ataaaaaatg gggaagagct ccattcagta 1404061 ccgctgccga ttgcagggtt attatccgac caatctgcag agcaagtgaa tcaaagcttg 1404121 ctgacgcttc atgataaatt gtcgttaatc ggtttcacag gcggatttaa tccatttttg 1404181 acattgtcgt ttttagcgtt gcctgtcatt cctgatatta aaatgacgac tacgggatta 1404241 ttcgatgtaa aatcatttca acacatatca ctgcaataaa aagaggcact cccttaggga 1404301 gtgcctcttt ttttaaacct ccataatgat cggcaggatc attggacggc gctttgtttt 1404361 ttcgtacaag aaaggtgcaa gcgtgtctgt aatttcgttt ttgatttcag accattgagt 1404421 cgtttttcgt tccattactt tttgtaagtg atttgaaatg agctcttgag cgtcgttgat 1404481 caagtcacca gattctctca tgtacacaaa tcctctggaa atcaaatcag gacccgctga 1404541 aatcttgaag tcgtccatgt caatgctgac aacaacgatg acaagtcctt cttcagagag 1404601 aattctgcga tcacgaagta cgatattgcc aatatcaccg ataccgcttc cgtcaatgta 1404661 cactgaaccg gacgggattt ttcctgcaac tgaagcctca tcgcctttaa gtgctaatac 1404721 ttcaccatta tccatgataa agcagttttc ctctgggatg ccacaatctg ttgcaagttt 1404781 gacatgcatc ttttgcattc tgtactcacc gtgaatcggc atgaagaatt taggcttgat 1404841 taaacgaagc atcagcttct gttcttcctg tccgccgtga ccggatgtat ggatatcgtt 1404901 aagagggccg tgaataacct cagcacccgc acgatacagc tggttgattg ttcgactcac 1404961 gctgattgtg ttgcctggga taggggatga agaaaatacg actgtatccc caggattgat 1405021 tgaaatttgg cggtgtgtgc cgtttgcaat tcttgataac gccgccattg gttccccttg 1405081 gcttcctgta cataaaattg ttactttatt agcaggcata cgattgattt cgttatgctc 1405141 aataaacgta tttttaggac agttaatata accgagtgtc tgtccaattt cgatagccga 1405201 ttccatactg cgtccaaata cggcaacttt tcttccattt tgtacagcag cttcaattac 1405261 ctgctgcaag cggtgaatat tcgacgcaaa tgtggcgaag ataattcggc cgtccacctt 1405321 gcggaaaatg tcatgaatgc tttctcctac acggcgctca gacatggtaa actccggatt 1405381 ttcactgttt gtgctgtctg aaagaaggca caaaacgcct tctttaccga tttcggccat 1405441 tttcgttaag tttgccggct cgccgactgg agtaaagtcg aatttgaaat ccccagtatg 1405501 tacgatgttt ccgggcggcg tttttacaac aatgccgtag gaatccggaa tactgtgtgt 1405561 tgttctgaag aatgacacag ccgttttgcg gaactttaca atatcatcct cgccgataat 1405621 gttcagtttc gtctgtctca ataatccatg ctcttcaagt ttattccgaa gtaagccgat 1405681 cgcgagtttt ccgccgtata caggaatatt cacttgtctg agcaggtatg gaataccgcc 1405741 gatgtggtct tcgtgcccgt gggtgataaa aagcccttta attttatctt cgtttttgac 1405801 taaatacgta taatcaggga tgacgtagtc aattccgagc agttcgtcct cgggaaactt 1405861 gatccccgca tcaatcagta caatttcatc ctggaattgc accgcgtacg tatttttacc 1405921 gatttcgccc aaacctccga gggcgaaaac agcagtctga tcatttttta caaatttcat 1405981 accgctcata actccaatac tttaaaattt tcgctctgtt gttcatattc taagaatgca 1406041 ccatcaacag gtgtaataaa ctcaatatta aatttctttt ctttcagctt tgttctgacg 1406101 tcacgctcag atacgccttc aatataaagt gaatctgtct tttcccgaac aggtacttcg 1406161 tcagccttct cttgataaaa taccttataa atcattccaa atctctcctt aaatgccgta 1406221 tgttagactc gctcattcta ttatattcga aaacggaata taaggaaagc cttgagcaaa 1406281 ataaggatct ctcaaaaagt gaaagatccc ttgtcaggca attgctttct tacggagcat 1406341 tccgttccat tgtcttctga gtttctttct taatttacgc agcattagcc agtccctcct 1406401 ttaatgaaaa atttgtccca gagttctttt atacaaatag tatacggaga ttgaggaaga 1406461 cttttcgtgg ttattaatgg aatttaatat gatttttgaa cgaaattgtt tgctgaatga 1406521 caatcttttt gtatgatgag ggtgggaatt gcagaccaag acgataaagg ggaagttgcg 1406581 atggattcta aattaatctt ttttgatatt gacggcacaa tatatgatca tgataagaat 1406641 ataccggaaa gtacgagaaa aaccgtggcg gagcttcagc gccaagggca tcatgtgttt 1406701 attgccagcg gccggtctcc atttttggtt aagccgattt tggaggagct gggcatccac 1406761 tcatttattt cctacaatgg acagtttgtt gtctttgaaa atcaagtgat ttataaaaat 1406821 ccgctgcctg aaaatgcaat caggcgatta ttaaagcagg cggatgaagg caagcatcct 1406881 gttgtgttta tggctgagga cacgatgaaa gcgactgttg cggatcaccc ccatgttctc 1406941 gagggaatcg gcagccttaa aacagattat ccagagaccg atgacctttt ttatgaagga 1407001 aaagaaattt ttcagcttct tttattttgt caggatgaag aagaaaaagc ttatgccgct 1407061 tttcctgagt ttgatctagt tcgctggcat gagctatcga ctgatgttct gccgcacgga 1407121 ggttcgaagg cagaaggaat caaaaaagtg attgagcgtc ttccgtttga tatcggcgat 1407181 acatatgctt tcggcgacgg attaaatgat ttgcaaatga ttgaatacgt tgggacaggc 1407241 gttgctatgg gaaatgctgt tcccgaactg aaagaaatcg cggactttgt aacaaaaccg 1407301 gtggacgagg atggaattgc atacgctgtc aaagaattgg gccttttaaa ataaagaaac 1407361 ggctggcatt gtgccagccg ttttctcttt tagcgctcaa ttgcgattgc attttcaggt 1407421 tctttgaaag gattttcctt atcaatatga tcatagaaca taacgccgtt caaatgatcg 1407481 atctcatgct gaaacacaat agccggaaat ccttttaaac gaatatcaat attttcgcct 1407541 tctagtgttg ttccttttac tctgatgcga gcatagcggg gaacataacc gggaatcgct 1407601 tcatccacag agaggcagcc ctcgccgctt gttaagtagc ttttttcaac tgaatggctg 1407661 acgatcttag gattaaacag agcatagctg tataatttac cggaagcatc ttccgcatga 1407721 acggcgatca ttcgtttttt gatattaatt tgaggagctg cgagtcctac gccagggcgc 1407781 agcttgtatt tttcggctaa ttctggattt tggctgtttt taacaaattc gatcatgtcg 1407841 gccagctgct gtttttctgc atcagttgga ggcagctcaa caggttcggc agtctctctg 1407901 agggctggat ggccgtcacg tacgatgttt tccatagtaa tcaagaaact tcactcctaa 1407961 agcttaatat gtaaattata tcggatttct tcacaaaggt gcaacgaaac gaatgaccag 1408021 ccgtatatgg ctggtcaatt tcatgctgtg tggttagcaa cagcctccac ctaaataagc 1408081 agctccgaca atgattaaca gaatgaataa aacaacgatt agcgcaaagg tgcggccgta 1408141 gccatatccg cagccaccat atccgtaacc accataactg cagcagcctc cgccgtaacc 1408201 atatccatac atattacata acctcctctt ttaattacgc cagagccttt ataagtaggc 1408261 atagcgtcta atataaccta tgtaaaaaca aaaaagttgt atggtcatct gtcctgattt 1408321 ttcacttttt tgatttaatt tcagtattgc atttatacag cacggctatt gccaaatgtc 1408381 cccatggatt ctatagtaga aattgtcaag attgggggat ttaacgtgaa agacgctata 1408441 aaacggcggc ctggaatcaa gatcggagct ttttgtgcca tggcactgat attaacagga 1408501 tgcatgggac aggacccggt tgattcactt catcattcat tagaaaaagc cgcggaatcg 1408561 gaaaagccgt ttcaagaaga acaaaacaca ctcaaagaat tagaggccaa agaaaatcag 1408621 ctttacgata gtgttatgaa gctcaatatg gatgattata aaaaaattgt tgctttatct 1408681 aataaggcgc ttgaaaatgt cagcaagcgc gaagaacacc taaagcttga aaatgacagc 1408741 atgaaaaaat cggaaacaga atttgaggaa gcaaaaacgt cagcggaaca tattaaggaa 1408801 aaagacataa aagaaaaggc cgatgccgca gcaaaccata tggagaaaag atatacatca 1408861 tatggcacta tgtataaaga gtataaaaaa gcgcttgagc ttaataaaaa actgtatatg 1408921 cagctgaaag acaaagattt gacaagagat gatctggatc agcagatcga taaagtcaat 1408981 gcttcttatg aaaagatcct taaatatagc ggagaattta atgaacaaac cgaaaaatat 1409041 aataaagccc gggaagattt atatgatgct gcaggctatc gtgtgaaaaa gagctgactc 1409101 gatcagctct ttttttgaat gaaatgcgat tcggatttcg ttcaaaattt tcatttctat 1409161 tgtagtacag catagtaagg tatactagta cagttttggg tgcggttggc atctgttttt 1409221 ttgatgaaaa tgtaaagcga atacatttat tgaaaatcag cgatgaaaac gattgacggt 1409281 tcttctttat ttggtgtaaa ctaatccatg ttaagcggtg ttgtattagt tttttacaac 1409341 ttcgaaataa tacagttcaa agcagagtgt aactatccta cataaaaggt tttggcaaac 1409401 tggggatcgg ctaaaatata atacgactta ctgctgatac tttagggtac cctaagtttg 1409461 tatgtataaa aggaatgcac gtctaatgac tgtttaaaag aaaggaagag gtgacttagt 1409521 atggctgcaa aaacgaaaaa agctatcgtt gacagtaaga agcaatttga tgccattaaa 1409581 aagcagttcg aaacgttcca aattttaaat gaaaagggag aagtcgtgaa tgaagcggcg 1409641 atgcctgatt taactgatga tcaattaaaa gagctaatgc gccgcatggt atttacgcgt 1409701 gtgcttgacc aacgctctat ctcattaaac cgtcaaggac gtctcggatt ttacgctcct 1409761 actgcgggtc aagaagcttc tcagattgca acgcatttcg cgcttgaaaa agaagacttt 1409821 gttcttcctg gataccgtga tgtgcctcag ttaatttggc acggccttcc attatatcaa 1409881 gcgtttcttt tctctcgcgg acatttcaga ggaaaccaaa tgcctgatga tgtgaatgcc 1409941 ctttctccac aaatcattat cggtgctcaa tacattcaaa ctgccggtgt tgcgctaggt 1410001 cttaaaaaac gcggtaagaa agctgtcgca atcacttaca ctggtgacgg cggagcttct 1410061 caaggggact tctacgaagg aattaacttt gccggagctt ataaagcacc tgcaatcttc 1410121 gtggtgcaaa acaaccgtta cgcgatttca actcctgttg aaaaacaatc tgcagctgaa 1410181 acaattgcac aaaaagctgt agctgccggt attgtcggcg tacaagtaga cggaatggat 1410241 ccgcttgctg tatacgcagc aactgctgaa gcacgcgagc gcgcaatcaa cggcgaaggt 1410301 ccaacactaa ttgaaacact tacattccgt tatggcccgc acacaatggc tggtgacgat 1410361 cctactaaat atcgtacaaa agaaatcgaa aatgagtggg aacaaaaaga tccgcttgta 1410421 cgtttccgtg cgttccttga aaacaaaggc ttatggtctg aagaagaaga agcaaaagtg 1410481 attgaggatg cgaaagaaga aattaagcaa gcgatcaaaa aagctgatgc tgaaccgaag 1410541 caaaaagtaa ctgatttaat gaaaatcatg tacgaaaaaa tgcctcacaa ccttgaggag 1410601 caatttgaaa tttatacaca gaaggagtcg aagtaagcca tggcgcaaat gacaatgatt 1410661 caagcaatca cggatgcgtt acgcacagaa ctgaaaaatg acgaaaatgt cttagttttc 1410721 ggagaagacg ttggtgtaaa cggcggcgta ttccgtgcga cagaaggatt gcaaaaagaa 1410781 ttcggtgaag accgtgtgtt tgacacgcca cttgctgaat ctggtatcgg cggtcttgcc 1410841 cttggtttag gcttaaacgg cttccgtccg gtaatggaaa tccaattctt cggatttgtt 1410901 tatgaagtaa tggattcagt ttctggccaa atggctcgta tgcgctaccg ttctggcgga 1410961 cgctggactt cacctgtaac aattcgttct ccattcggcg gcggtgttca tactcctgaa 1411021 cttcacgctg acagcttgga aggtcttgtt gcacaacagc ctggtatcaa agttgttatt 1411081 ccatcaactc cttacgatgc caaaggactt ttaatttctg cgatcagaga caatgatcct 1411141 gttgtcttct tagagcatat gaagctttac cgttctttcc gtcaggaagt tcctgaagaa 1411201 gaatacacaa ttgagcttgg aaaagctgac gtgaaacgtg aaggtactga tctttcaatc 1411261 atcacttacg gcgcaatggt tcatgaatca ttaaaagctg ctgatgagct tgaaaaagac 1411321 ggcatttctg ctgaagttgt cgaccttcgt acagtaagcc cacttgatat cgatacaatt 1411381 atcgcctctg tagaaaaaac aggacgcgcg attgtcgttc aagaggcaca aaaacaagcc 1411441 ggtattgctg caaacgtagt agcagaaatt aatgaccgtg cgatcctgag cttggaagca 1411501 cctgtacttc gcgttgcagc gccagataca gtatttcctt tctctcaagc ggagagcgta 1411561 tggcttccaa accataaaga cgttcttgaa acagcaagaa aagtgcttga attttaatca 1411621 aactgcataa tcgagaggga agatgaacgt tttccctcta ttatatatct gttttcaatg 1411681 cttacgatgt aaactttaaa attgcttaat caaactagga ggtcgagaac tgtggcattt 1411741 gaatttaaac ttccagatat cggggaaggt atccacgaag gcgaaatcgt aaaatggttt 1411801 gtcaagccta acgacgaggt agacgaagat gatgtactgg ctgaagtcca aaatgataaa 1411861 gcagtagtag aaattccttc acctgttaaa ggaaaagtat tagaattaaa agttgaagag 1411921 ggaacggttg caactgttgg acaaacgatt attacgtttg atgcacctgg ttacgaagat 1411981 cttcaattta aaggcagcga cgagtctgac gatgcgaaaa ctgaagcaca agttcagtca 1412041 actgcagaag ctggacaaga cgttgcgaaa gaagagcaag ctcaagagcc tgcaaaagct 1412101 actggcgcag gacagcagga tcaagctgaa gttgacccga acaaacgcgt gatcgctatg 1412161 ccttccgtac gtaaatatgc acgtgaaaaa ggtgtagaca tccgtaaggt tactggttca 1412221 ggcaacaacg gacgtgttgt aaaagaagat atcgacagct ttgtaaacgg aggagcgcaa 1412281 gaagctgcac cgcaagaaac agctgcacca caagaaacag ctgctaaacc ggctgctgca 1412341 ccagctccag agggcgaatt cccagaaaca cgcgaaaaaa tgagcggtat ccgtaaagca 1412401 attgcaaaag cgatggttaa ctctaaacac actgctcctc acgtaacgtt aatggacgaa 1412461 gtggacgtaa caaaccttgt tgcacatcgt aaacagttca aacaggttgc tgctgatcaa 1412521 ggaatcaagc tgacttactt gccttacgtt gtaaaagctc ttacatctgc actgaaaaaa 1412581 ttccctgttt taaacacgtc aattgacgat aaaacagatg aagtcatcca aaaacattac 1412641 ttcaacatcg gtatcgctgc tgacactgaa aaaggcttgc ttgtaccggt tgtgaaaaat 1412701 gcagatcgta aatctgtctt tgaaatttct gatgaaatca atggccttgc aacaaaagct 1412761 cgtgaaggca agcttgctcc agctgaaatg aaaggcgcat cttgcacaat tacaaacatc 1412821 ggttctgccg gcggacaatg gttcactccg gttatcaacc atccagaagt tgcgattctt 1412881 ggtatcggac gcattgcaga aaaagcgatt gttcgtgatg gcgaaatcgt agcagctcca 1412941 gtcttagctc tttctctcag cttcgaccac cgtatgatcg acggagcaac tgcgcaaaat 1413001 gcattaaatc acatcaagcg tttactgaac gatccacaat taattttaat ggaggcgtaa 1413061 tgttatggta gtaggagatt tccctattga aacagatact cttgtaattg gtgcgggacc 1413121 tggcggctat gtagctgcca tccgcgctgc acagcttgga caaaaagtaa cagtcgttga 1413181 aaaagcaact cttggaggcg tttgtctgaa cgttggatgt atcccttcaa aagcgctgat 1413241 caatgcaggt caccgttatg agaatgcaaa acattctgat gacatgggaa tcactgctga 1413301 gaatgtaaca gttgatttca caaaagttca agaatggaaa gcttctgttg tcaacaagct 1413361 tactggcggt gtagcaggtc ttcttaaagg caacaaagta gatgttgtaa aaggtgaagc 1413421 ttactttgta gacagcaatt cagttcgtgt tatggatgag aactctgctc aaacatacac 1413481 gtttaaaaac gcaatcattg ctactggttc tcgtcctatc gaattgccaa acttcaaata 1413541 tagtgagcgt gtcctgaatt caactggcgc tttggctctt aaagaaattc ctaaaaagct 1413601 cgttgttatc ggcggcggat acatcggaac tgaacttgga actgcgtatg ctaacttcgg 1413661 tactgaactt gttattcttg aaggcggaga tgaaattctt cctggcttcg aaaaacaaat 1413721 gagttctctc gttacacgca gactgaagaa aaaaggcaac gttgaaatcc atacaaacgc 1413781 gatggctaaa ggcgttgaag aaagaccaga cggcgtaaca gttactttcg aagtaaaagg 1413841 cgaagaaaaa actgttgatg ctgattacgt attgattaca gtaggacgcc gtccaaacac 1413901 tgatgagctt ggtcttgagc aagtcggtat cgaaatgacg gaccgcggta tcgtgaaaac 1413961 tgacaaacag tgccgcacaa acgtacctaa catttatgca atcggtgata tcatcgaagg 1414021 accgccgctt gctcataaag catcttacga aggtaaaatc gctgcagaag ctatcgctgg 1414081 agagcctgca gaaatcgatt accttggtat tcctgcggtt gttttctctg agcctgaact 1414141 tgcatcagtt ggttacactg aagcacaggc gaaagaagaa ggtcttgaca ttgttgctgc 1414201 taaattccca tttgcagcaa acggccgcgc gctttctctt aacgaaacag acggcttcat 1414261 gaagctgatc actcgtaaag aggacggtct tgtgatcggt gcgcaaatcg ccggagcaag 1414321 tgcttctgat atgatttctg aattaagctt agcgattgaa ggcggcatga ctgctgaaga 1414381 tatcgcaatg acaattcacg ctcacccaac attgggcgaa atcacaatgg aagctgctga 1414441 agtggcaatc ggaagtccga ttcacatcgt aaaataattt tcatatcaaa aacagccccg 1414501 ctttgagcga gggctgtttt tttattttga cagcacatgc tgtaatggtt taatgatgtc 1414561 ttctttcttt ttcacacatc cctcgatttt caccacgaca tggcgctgat caacaaccat 1414621 aagggtaggg acagtttcaa tctcatcttc ccagccttct tttttatcat agaccttcat 1414681 tttatctatt tgctcgggat aatctttttc taaatcaagc agtgcatcgt aataaggcgc 1414741 ttcctggtct atttggttct catcagaaaa aaacaggatt tgtgtatgat gaatgttgtc 1414801 aatccggctt tttttcatcg gattgatggt ggaaagcgta cagcccgata aagcaaatac 1414861 tattatcagc atggggaata ccgcgcgata tcgcatctat cttctcctct gtataaacag 1414921 tagttaacta gctttagttt atcacgagag acggcttaat ctgcttcttg ttacctaatt 1414981 gttatataat tgaaaccgtt tttaaagtga gattacatat tatatcaatc gtttaaaata 1415041 gcaacctggg gtatattgaa ttttttgctg cattcttgga tgaaagttca agaaaacgtg 1415101 caattacatt atgtgctgtg gcatatatat cgagtaaagc ttctgtatga agaagatatt 1415161 gtatgatgga aaatggaaaa acaaggtgaa tatgatgata tgaaataaaa tgtgttatac 1415221 agtttgttgt tgacatttta aatgtgacat attaatataa taacaacaaa agaaattaag 1415281 cgttttcaaa tttcaaagaa atggggaata agagatgggt acgattgttt gccaagattg 1415341 caacgaagcc attcattact ttgaagatga gaaagtgaca acattatatg gaacttgctg 1415401 cggacaatgt caatgtcctg ttgatgaaga gtaaaaaaaa gcatgcggct taaagccgca 1415461 tgctttttat tttttattga attgcttttt gttctttgat gacccggatc atatgtaaag 1415521 tcgagtcctc aggtccttga acagggaggc ctgcgtcaag gtttttaaaa atgtagctga 1415581 tgttttcttc tgtaataatt tctcctggga tgaagattgg aataccaggc ggatatacca 1415641 tgacaaattc agcaataatc cgtccggatg cttcttttaa tgggatgact tccgtatttg 1415701 catagaaagc atcacgcgga gtcattgcca ataaaggtat ttctggaagc agaacctcag 1415761 tttgctgatg tgttacatct tgttctgaca tttgctgtgc gatctcagtt aaagcctcta 1415821 caagccggtc tgcatcattt tggctgtcac caggagtgaa aatacacaaa atattgtaca 1415881 gatcagaaag ctccacctca atattaaagg attcacgaag ccatttttcc acgtcatgtc 1415941 ctgtcaggcc aagacttttc acagagataa tcaattttgt cggatcatag ctgtaagctg 1416001 ctttcgaccc aagaatctca gaaccgacac aataaatgcc ttcaatctga ttgaggcgat 1416061 ctctcgtctg attggcaagc ttgagtgttt cctcagcaag ctggcggcct tctgttgcaa 1416121 ggcgttttct ggcaacatcc aaagaagcga gaagcaagta agaagttgac gtagttgtca 1416181 gcatgctcag gatggattgc actctgtctt tagatacaag gccttctctc atgtttaaaa 1416241 tagagctttg tgtcagtgat ccgcccagct tgtgtacact tgtcgctgct atgtccgctc 1416301 ctgcctgcat agccgatagc ggcaattcgt cgtgaaaatg aatgtgaacg ccgtgtgctt 1416361 catccacaag cactggcaca tcaaacgaat gagcgagttc tacgatgctt tttaagtcgg 1416421 ctgcaacacc gaaatatgtc gggttgatga cgagaagccc ttttgcatcc ggatgctcgg 1416481 taagcgcccg tttagcagat tcaagtgtaa ttccgtggga gatgcccaat tcattgtcaa 1416541 tttcaggatg aataaaaatt ggaaccgctc cggaaaatac aatagctgtc ataattgatt 1416601 tatgaacatt tcttggaata ataattttat caccaggtcc gcaaacagcc attaccattg 1416661 tcataatggc gccgcttgtt ccttgaacag aaaaaaatgt atgatccgct ccaaatgctt 1416721 cagcagccag atcttgtgct tgtttaataa tgccttttgg cgcgtgcaga tcgtctaatg 1416781 gttcaatatt aatcaaatct atgcttaacg cgttttcacc gataaattgt ctgaattctg 1416841 ggtccattcc tgcccctttt ttatggccgg gaatgtggaa ttgaacaggc tgtctgcttg 1416901 catgcttttt cagtcctgtg tataagggtg tttcatgttg cgacaattgt tttcccacct 1416961 ttgtaatcat acctatgcat aatagtgtgt attaaaatca gtttctcaac cgttttttag 1417021 acgtaaaaca aatgaattat attatgaact tgaaagaatg taaagaacaa tttatgatca 1417081 aatgaagatg ctttctctta agggaagtaa atctacaagg agtgaagaaa atggagtatc 1417141 aatatccgat gaatgaagat tggacaaccg aagaagcagt ggatgtgatt gcatttttcc 1417201 agcaggttga gcttgcatat gaaaaagggg cggatcgtga agaactgctt aaagcttacc 1417261 gccgtttcaa ggaaattgta ccggggaagg ccgaagaaaa aaagctatgc ggcgagtttg 1417321 aggaacaaag tacatattct ccttatcgca cggtcaaaca ggcgagagaa tctgatcacg 1417381 cgaagattaa gatgtaagaa aaagagccgg gggatatccc ggctcttttt tatgcttgtg 1417441 ttactttttg ggtgagacgg tacagaaaag caagctgttt aaaggcatcg tcgatacgct 1417501 gaaggaattc ctggttattc atattcagca cttcttcttt ttggagctgg atgccgcata 1417561 acagctcggc tttctttaca gtctgcaaac gctcaaacag tgtcttcagc tgttccttgt 1417621 ccatttcaga ctgtttatgt actcccggtt ttgtgtgatc tgcagaccaa acgaagctgt 1417681 cagggatatt tttcgtaatg gtttcttggt tcacttcaag caatttgccg tattcttctt 1417741 tgatagggga ttcataaata atcgcgaacc atacaaagac gtggctttcc cataaaccaa 1417801 tttggaaatg cggcagtttt ttatagcctc ttttgctgtt tgcgaacgcc acccagctgt 1417861 cagccggggg attgacggat cttcttgcgt gctttgccac atgcggaaac atttcatctc 1417921 cggttaaagc tgataaagtt ggggcaaaat gttcgcctag agctgtaagc ttcggacgga 1417981 ccgtctcttt taatacttcc atgcgcgcgt ctaagccttc tattgtaaat gtgttaaagt 1418041 cttcttcagt gaaacgcatt tgtgtcatga ttttcctcct tcatgctaag tatacatatt 1418101 ttatcacagt tcatacgagc ttcaaaaaga ttgagcgcgt ttgaagtaag gagaaatgtg 1418161 gtaataaacg agtaggtaaa cacacaattt tcagaatcat gttgcgcgta aatagaacaa 1418221 tcatacgata taagaagtaa tcattgttga atggcaaaat gggatgcttt tttacaaaca 1418281 aatgatctct ggaaggggcg aaagacaatg aggcaagttg taaaagaggg atttaaggaa 1418341 gagaaaaaca atcgtgttgc tgtctggaga ctagaggttg attatgaatt ggcaacccta 1418401 tatgaagcaa tgcagaaaga aaatgaagag cagattgaac aaagcaaaaa caaacttgag 1418461 cgacttagaa aagaatggat tcgtcttaac gggtaaaaaa gcgatagtga aaacgaaccg 1418521 catgaatggt tcgtttttac gtgagaaggg atatttttca ttttccttgc tttttcattg 1418581 ccgttatcag tatcctataa aataaaaggt ctacatagaa gagaggtacg aacgaatgac 1418641 aaattggacg gaaatcgatg agattgcaaa gaaatggata agagaagcag gcgcgagaat 1418701 tacacaatcc atgcatgaaa gcctgacaat tgaaacgaaa tcaaatccga atgatttagt 1418761 caccaatatt gacaaagaaa ccgaaaagtt tttcattgat cgaattcaag aaacatttcc 1418821 gggacatcgg atactcggtg aagaggggca aggagacaaa atccactcac ttgagggagt 1418881 cgtatggatt attgatccga ttgatgggac gatgaatttt gtgcaccagc aaagaaattt 1418941 tgcgatttcc attgggattt ttgaaaacgg tgaaggtaaa atcggtttaa tttatgatgt 1419001 ggtgcacgat gagttgtatc acgcatttag cggcagagga gcttatatga atgaaacgaa 1419061 gctggctcca ttaaaagaaa ccgtcattga agaagcgatt cttgccatta atgcaacatg 1419121 ggtaacggaa aacagaagaa ttgatcaaag tgtgttagcg ccacttgtga aaagagtcag 1419181 aggcacacgc tcctacggtt ctgccgcttt agagctggca aatgtcgcgg caggaagaat 1419241 agatgcttac atcacgatgc ggcttgcgcc atgggactac gcagccggct gtgtgctgtt 1419301 aaatgaagta ggaggcacct atacgaccat tgaaggagag ccgtttacct ttttagaaaa 1419361 ccacagtgtg ctagccggaa acccatctat acataaaacg atatttgaag agtatcttca 1419421 tgctcggaag taggccattt gagcaggatg atctcagctt gttagaaaag ctcgcggagg 1419481 ctcatcctgt atggaaagag gaggagtttg gagataaaga tgcagaagac tatatcattt 1419541 cctactccat gtacaacggt tcatggcttg tatgggaaaa agacggtatg cctgttgccg 1419601 tcagctacca tctcgagtgg tctccttcaa acggtaagcc gtggctcgga acggtcctga 1419661 ttgacccggc tgaagaaaaa aagggacatg cgaagatgat cattgaacag atcagcaaat 1419721 tgcttagagc gaaacataaa gcgatgtttg cgggagttcc cattgagcgc agggaatgga 1419781 tactgttttt aagccaatgc ggctttgaac agctgaaaac ggaaaaagat gagaaaggca 1419841 aatcatttat gatcttggtg aagcctttag cagaagctgc cgtatgataa tggcagctta 1419901 tttgctgcat gcgggttcaa taaaaagcct ctcaaacatt gagaggcttc tgatgatttg 1419961 aaaattattt ttttaccgca tgaatataat gaatcgtttc aaacgctgac aaattgtctt 1420021 ttcgattact aaagaaaagg tcattgatgt cgtctggtga tagatgttca tagatcagta 1420081 aaccagatga ctctaacaga tgttcaatct cttgataagt gaaacatgat ttcatcggtt 1420141 ccccgcttgc ggcagccatc ttcaccatat gttcaactcg attcgacgtc ccttttgctg 1420201 taaaaagtgt ttcgtccgca taatcaaaaa caatagagct tccaggcggg acatgagaaa 1420261 ataaattgct gatcaagctt gcattttctt cccgtgttac ataataagac actccgagaa 1420321 ggctgaagaa tgtttttgtg tttttaaatc cttcatctaa gagaggatca tacgaaaacg 1420381 ttttggtgaa atccatagga acaaaatgaa gatgacccgg aattgtcaga tttgcatcct 1420441 tcagcttatt ttttttcaat tgctgtgtgg ccggatgatc aacctcgaaa acctgtaagc 1420501 tgttttctaa ttctggatgc cgaaagcaga aagtatccag tcccgctcca agaatgacat 1420561 actgttttgc ccccaggatt aattcgttgt gcaagacttt ttcacaataa gaagcacgtg 1420621 ctaggggcgt tggagacagc tggatttgtg caacccattt taatattttt tcaggatcat 1420681 tttgaagacg ttcggcgatc tctttgttga aaaacgatat ttcttgaatc atatttttac 1420741 tgatgtcgat aaactctttt tcgttaatga gatcttttgc gataaaatca tcaaaaataa 1420801 gaggtgtgtc atatcggctg tgatatgcac gggcaaaagc tgaaattaga gacgttaagc 1420861 tggactcatt tttcctcatg aaatgatcct ccacaaaaaa taagattccc ctggccagga 1420921 gaatcttatt atacatacaa atatattaat agtaaatttt agcataaata aatttttttg 1420981 tcaatgtttt tgctcttaac tggacgcgcg atccttcaca tagccacgtg acctgtagca 1421041 gaattcgtct atcaattatg tggactgaat cattagcttt tataaaatgc gcacttgcgg 1421101 ctgcatccct ctttatgcaa atcaggagcg gttttctgtc tcatggcagc atcttttcgt 1421161 cgtttcagct gagagagaaa tcaagatatg taacaataaa agcctgaggg atctcaggct 1421221 tttcctaata ttacaatcca acagcattcc aggctgcttc aactttagcg gcatcagttg 1421281 agccgtagag gtcacgggca gactgaatga gagctgcctt ggcatctttg aacgtggaag 1421341 aaggcgtgag gtacgttgtt aacgcacggt aatagatttg ctgtgattta gatacaccaa 1421401 gttttgtgat ggtgttgtaa gcggctttgt ttggaattcc gctgtttgtg tgtacaccgc 1421461 cataatcgcc ttcatctgtg tttggaaggt ttcggtaatt ggcgtaattg tcaggctggt 1421521 tgtattttgt agggttggac aggctgcgaa gagcaggctg gctgaccgta atgtcttcac 1421581 cgatgtccca gtcttctgta tcgttaaaat acccgaatac gtcagagaaa gactcgttta 1421641 atgcacctgg ctgattttca taaatcaagt tggctgtttc ttgggtgacg ccatgtgtca 1421701 tttcatgcgc tgtcacatct aatgagccgg aaagcggaga gaagaatgaa ccgtcgccat 1421761 caccgtaaat catctggtct cctgtccatg cagcgttatt gtattgagtg ccgtagtgaa 1421821 cggaagaaac gattttactg cctttgttat catagctgtt tcgtttaaag tttgaataaa 1421881 aataatcgta cactttaccg aggttatagt gtgcgtcaac ggctgcccgc tgtgatgaag 1421941 atgtaaatgt tttcgttgtg cttgagacaa gcgtgcccgg aaggcggctt tgtctgtttt 1422001 gcaaatcata tgtgatgatt tgggtgcctg ttggttttga aagatctctt agaacatatt 1422061 ttccgccttc ataagagatg ttcaaaggaa cagttgcgcc ctttagcgtt gttccgcttc 1422121 cagtggcggc ggcatgttct actttatttt gctgttttaa aatgctgcct gtttcggcgt 1422181 caactaagac ttcccagttt gcaggttcag gctcgacata gcgaatcgtc acgtcgtaag 1422241 caagacgata gctgccgtct tttgtttcta tcgcttttaa ttcggcttta ttgctgtttt 1422301 tggccgctcc gttagaaaca gcgtctggtg atttgccgat agctttgaaa gcgagtgcca 1422361 gcgctttttc agaagagact ttttggctgt tatctgtttt tgcagcagat tgattgtgta 1422421 attcaccatt gaccgcatag acattatcgg atttatcgac gtgaacgatc acttgcgaat 1422481 ctttaattgg cactccgtta acgacaggcg catatcgaaa gtgcttgtat ccaagggcat 1422541 cagtcgtgct ttcaacaagc ttcagccttt tggaagggtc acctttaaaa atgttgctgt 1422601 tctttttcaa aaactgcttg acagccttgt catttggtgc agagagttct gattgcgcaa 1422661 tcgcgttttt ggagaggaaa tttgtttgat tctctttaag ctgatgacct tcagcagcct 1422721 gaacacctgg caggctgatt gataaactca taaacgaagc agcgacagca acagacaatt 1422781 tcttacctaa acccacaata aatccccctt tttgaaaata ctgaaaactt tatattgtta 1422841 tattaaacta gcattctgga atactcaaca aaaactaaca taactagaca aaattgatag 1422901 tattgtcctg tgtttgtttt tgttgaataa tatcaagatg agtcaagtgt catgtggtgg 1422961 ttcattcaag agttatgttt tttacatatc aaggggaaga tgagatattt ttgtttcatc 1423021 ttgaaacttt ttgaaaagtc cgctgtctaa ccgaatgagg ccttaataag aagtaaagga 1423081 ttgttgttcg tgttggagtt attcagtcat tatgtattgc atttcgaacg ttattttata 1423141 ttaagcagac aaagcaccct gctgattcaa tggtcaattg ttgttctggc gggcttatat 1423201 cttttggtgc atcatcccaa aataaaccgg cagcgcacaa tgttcttggc gggtgttata 1423261 ttgcggattg tgctgctggc gggagtgtct gttgaactta ttcaccaggt gcaatcaaca 1423321 aacttcacca gcgcttactt aagagaggac ggaaaagaac tgctgccgct gctgcatttt 1423381 ttgttatacg gatatgtgct gctgacggct tttcactata tgctgatgcc gcgtgatcat 1423441 ggcggaaagg gtaagtttta tacgttcgac cttgctgttg tcagtttgcc gatcgtacaa 1423501 atgattttta gtttcttttc gtattggaag gaatacccgg atgggatgga gccgattgca 1423561 ttcgtgtttc tgtttttcat catcactctt cccattgcgt tgaatgtagt gtttttcaag 1423621 ctgtattgga gaacggataa gatcttacta ggcttatttt atacgctgat tatcggactg 1423681 cttgtcttgc tgcttgcgcc atatcccaat caaatctcaa aagattatgg tgcagtaatg 1423741 ccatatacga tttatttggc aatggcggga tttttgatga gctatcatct gttccaaaag 1423801 tcaggaaagg tttatgtgcg tgtgaataag tgggtgacga tggctgtcat ggtgtttttt 1423861 gtcctgctgt taaatccgat atataacata ggaacggctg ctttcgctgt atcaaagcca 1423921 gcaaatgtcc atgattcatt caattttgtc ggggagcaca tttcatcaga aaaagcggaa 1423981 cagatactaa agtcattttt tcctacggat gaaacacttt atttgcacga tacaaacatg 1424041 gatgtgcatt atttctactc atttgaaagc aaaggttaca aagctgaggt agatgaagta 1424101 tcgcagctaa ttcgtaatta tgaatactta caaaaagcac atgggaaaaa gctaacgaat 1424161 caggagtaca agcgaaagtc catcgctttc cttgagcgac acggacgtgt gttacataag 1424221 gatcatatcg aaacaaaggt atctcaagaa gacggccaga cagtcgtacg tatttacctg 1424281 aaaaatcaac ttcataaaaa agatcatgct gatgatggcg cggtatttta ttgggaaaag 1424341 gaaaccttaa tggggtttag tgaagatcct tcgatttatc agcttgactc tcttctgcat 1424401 gttcatataa cggaacaaga cattcacgac aaagtggaac aaatgtttac agcgctgaac 1424461 atatcaaaac agccttatca gatcactgat attgaaagcg acagcctgct tggaagcatg 1424521 gtgagagttg aaacaaaagt tggaattgtt ttggaatttg agggcgaatc aggttgttta 1424581 catagtcttt cgcttccgat gaaaaagaat atctcaatgg ctaacagccg gctgcagcat 1424641 cagatattat cgatcttcga tgctcgtgga tcagaaaaga agaaaaaaag cagtcagggt 1424701 gacatggtga tgtatactga ttcttctaaa acatatgagt ttgttgaagc tcaaggtcag 1424761 ctaaacgttt atgtatacag cgatacacct gatcagtcat tcccctatac gtatcgtaat 1424821 ggaacattgg cttacgaaaa agtagcttct ctatatcagg atgtcattta caaaaagcgt 1424881 atgcgtccga ttatcgttca aagaggggat gaacggcatt atgcatggct gatcattatt 1424941 cagccgtttg gttcaaatcg ccatgatgcc tatgtagtgg atggagaaac acaagaggtg 1425001 aaaagtcttt atgaatcata aagaaaaaga gtctgttttt gtagacttat acgacctgta 1425061 taaagaagga gagctagagg atgaatcaat ggaatggatg aaacagcatg aatccctatt 1425121 tcaaaagaat gcggaagact taaagagtaa aacttgttta aagagaagtc ccggtgctga 1425181 agaagaaagc caaatcagat atatgaaagt atacctgtct tccatgtata tctgtttcat 1425241 tttattggcc atttggatga cggtgtggtt ttatttttaa tgaagcatag ggattccatt 1425301 gaggacttgt atcggcagta ttatcaagaa attttaaatt atttattcag aaggactcat 1425361 catcttgaaa cagccaagga cttagcgcag gacacgtttg taaaagctct taacggtctg 1425421 gcttcgttta gggggcattc ttccatcaga acatggctct acaccattgc gcatcatacc 1425481 tttatcaatt ggtaccgaag ggatgtcaaa taccaattta ctgaaatcag caaaaatgaa 1425541 gggttaacgc aaacaactta tgaccagcct gaacagtatc tgtcacggac ggtgaaaagc 1425601 gaaacactgc ggcaggagct cctgaagtta aaagatcagc atcaatccgt tttgatttta 1425661 agagaattcc aagagctttc ttatgaagaa atcgctgaga tattaggatg gagtctttct 1425721 aaggtgaata ccacattgca ccgggctaga ttagagctaa agaaaaacat gacgaaaagt 1425781 agagaggagg agcggatatg acctgctttc tagtaagaga cctgcttcct ctgtatcttg 1425841 aaggtgattg taaaagagaa acggaacacg ttatagaaga gcatttaaaa atgtgcagca 1425901 gctgcagaga catgtatgac acgatggctg agccatttga attggaaagc gaacaggccg 1425961 ttgaggaggc ttatctgccg gaagaagaac tgcgttttaa acagaggtac tatggattac 1426021 tgatcatgaa agctgcctgc tggtttggag cggcggttgc catgatgctg atcatcaaac 1426081 tgctgatata aaaaaagcgc ttgtccgatt ccggcaagcg cttttttaca ttaagcctgg 1426141 ggatgaatca tatcgtaaat agcggcaagc tgttcttgtg acagggcact gaagagtttt 1426201 tcataaacgt cagcttgcag tggcgttgca cctgcttgta gcgctgcgtc tttatcatag 1426261 ctgtacacat catcttgtag cacaatggct gcttgaagaa tgtgaatctt gagagaaaca 1426321 gcggagaaaa attgttcaag tgcaagtgct tctttttctg tgaagccaag ttcaactgct 1426381 ttttctgtat caaatttgta atttccatcc tcgagataca cacattgtga aacaatgctg 1426441 aaaaattctg atgtcgattc ccagagtgta gcaattacct gagcctcttc ttttgtcatt 1426501 cctaactcga cagctttttc gctgtcaaaa taatatacac cgtcttgttc gtatatacat 1426561 tgatttaata tatcaatgaa tgtattgaga tcttcgttag tgctcgcctg atgctggagt 1426621 tgaacagcag tgttatcaac cggtgttttt gcgctggctg catcaggacc gaacgttaat 1426681 agagcagctg aggtcattgc ggcagtcgtt aacatagctt tttttacaaa tgttttcttc 1426741 atgtttcttc tctccctttt atgaattgtg ctacaaattc cattataggg agtagtttcc 1426801 ggtggaggaa taggcgctat ggtattttat gtgtatcgtt gccgaactac tttttgaagg 1426861 ctgcacgtgt gatcgttaga acgattgtct atgtatgaag gctgttttgc atcttcctga 1426921 ctaagaaaca ggggagataa ggcttaaaga aatgaaaaac accgctttct ttgcggtgtt 1426981 ttttgattac aatgtcgccg gcggggcaat gcttttaatc aagcaagcct tgttcgcgca 1427041 ttttcttttt taatgtaaat ccgccgccca tgacagcgca aacaagtaca atgctggcga 1427101 taatgcctgc agggcttttt tcagcgataa agacgccgat cagcataatg ctgaaaaccg 1427161 ctgcaaatgc aaataatagt aaaagccaat tcattttttt cataaattcc atcccctttt 1427221 acgtcttata ttaagtttac agaaaaacgt gacgctttta aagaggatgt gtgatataat 1427281 atgaaagtta tctaattttt ttaggagatg aaaaagtgaa acttcgaaat gatcttcgca 1427341 acatcgcgat tattgcccac gttgaccatg ggaaaacgac tctagtcgat cagcttttac 1427401 atcaggctgg tacgttccgt gccaacgaac aggttgctga acgcgcaatg gactctaatg 1427461 atcttgaacg cgaacgcggc attacaatat tggcgaaaaa tactgcgatt aactataaag 1427521 atacacgtat caatattttg gacacccctg gacatgcaga ctttggggga gaagtagaac 1427581 ggattatgaa aatggttgac ggcgtagtgc ttgtcgttga cgcatatgaa ggctgtatgc 1427641 ctcaaactcg ttttgttctg aaaaaagctc ttgagcaaaa cctgaaccct gttgttgttg 1427701 taaacaaaat tgaccgtgac tttgctcgtc cagaggaagt tatcgatgaa gttctggatc 1427761 tgttcattga gcttgatgcc aatgaagagc agctcgagtt cccagtggta tatgcttccg 1427821 cgattaatgg aacagcgagt cttgatccga aacaacagga tgaaaacatg gaagctttat 1427881 atgaaaccat tattaagcat gttccggcac ctgttgataa tgcagaggag ccgcttcaat 1427941 tccaagttgc ccttcttgac tacaacgact atgtaggccg tatcggaatc ggacgcgtat 1428001 tccgcggcac aatgaaagtc ggacagcagg tttctcttat gaagcttgac ggaacggcaa 1428061 agtcattccg tgttacaaag atttttggtt tccaaggctt aaagcgtgtg gaaattgaag 1428121 aagcaaaagc gggagacctc gttgcggttt ccgggatgga agatatcaac gttggtgaaa 1428181 cggtatgtcc tgtagaccat caagatccgc ttccggtcct tcgcattgat gagccgacac 1428241 ttcaaatgac atttgtcgtg aataacagtc cgtttgcagg ccgtgaaggc aaatatgtaa 1428301 cggcccgcaa aatcgaagag cgtcttcaat cacagcttca gacggatgtg agcttgcgtg 1428361 ttgagccaac agcttctcct gatgcttggg ttgtttcagg acgcggtgag ctgcacttgt 1428421 caattttaat tgaaaatatg cgtcgtgagg gctatgagct tcaagtgtca aaacctgaag 1428481 ttattatcaa agaaatcgac ggcgtacgct gtgagcctgt tgaacgtgtg caaattgatg 1428541 ttcctgaaga gcatactggc tctgtaatgg aatcaatggg tgcccgcaaa ggcgaaatgg 1428601 ttgatatgat caacaacgga aacggccaag tccgtctcat ctttacagtt ccttcccgcg 1428661 gattgatcgg ttactctaca gaattcctat cattaacacg cggattcggt attttgaacc 1428721 atacgtttga cagctaccag ccgatgcagg caggccaagt cggcggacgc cgtcaaggtg 1428781 tacttgtgtc aatggaaaac ggaaaagcaa catcatacgg tattcaagga attgaagacc 1428841 gcggtgtcat cttcgttgag ccgggtactg aagtatacga aggaatgatc gttggagagc 1428901 ataaccgtga caacgacctt gttgttaacg tcagcaaaat gaaacagcaa acaaacgtcc 1428961 gttctgcgac aaaggatcag acaactacaa ttaaaaaagc gcgcatcatg tctcttgagg 1429021 agtctctaga gtacttaaac gaagatgaat attgtgaagt aacacctgaa tccatccgtt 1429081 taagaaagaa gatcctcaat aagaacgaac gtgaaaaagc agctaaaaag aaaaaaacag 1429141 caggattgtc ttaatctcgt gcagaatttg aaaagataga acccgtacgt ttacagggga 1429201 gggaatcttt ttgaatgacg taagcgaacg cctgtcgttc ttcgccgctc tatatcaagt 1429261 agaccggcag cctgcggcag gcatgtggct gctgtacggc acgatttttg tgttggccgt 1429321 tattgtattt aagcttggat ttgctaaacg gcttcctgta ttaaaatctg cagtggtgta 1429381 tgtatttttg gctttgggct gcactgtttt gactttttta ggggtgtttt tgcccgtggc 1429441 agaaggattg gtcgtcgctg cgctgatttt aatcatttac aaaatccggc tgtatcagtc 1429501 gaaaaaagga cagtctgcaa aatcataaaa gactcagctg aaagctgagt cttttttgtg 1429561 ttctgtatgg ttaagcggcc gctttatttt ttgacttttt cttttttctg ctgtcccggg 1429621 tgaaaagtaa attttcccgt tttcagccgt tcctctgttt ttttggcaat ccgatcgtgg 1429681 cattcctggc acatatatgt atggatcggg cggtttcgaa gccgtttcgc gatcagggta 1429741 tcatcatcaa ttgtttcaat tttatcgcaa atagaacatt tgaccctcat catatcacct 1429801 ctttcactaa catgtattat accacggatc agaagctgtc caaaataaga aaaagctaaa 1429861 gcgcaaggct atagcttagt cattgttgtt ctttttcata tgatgatcag attgatcgtt 1429921 ttgttccttc tccatttcct gttgctgttt tctatttaat tggtcatttt gctgctttgt 1429981 ttgcggttca tcttcattgt caatcacatc gttaggcact tcgggaagca ctcggccgac 1430041 aattgcagct aattcatcca gtatacctgt taccggatgg ccctcgctga tttctctgct 1430101 catttcgcga aggcggctga ccgtatcggg atcagcaatg actactgcgt tggcgccata 1430161 tcgatcattc tttagcgcct gagctacaga atatttaatg gtttccactt tgcttctgtc 1430221 caaagtatca tcgacatcaa tcccaacaac agcatagcct cccagcacaa cggctgttgc 1430281 atccttgacg tcggggtttt tttcagcaac gctgacaaga tgcttggcaa tatccgttct 1430341 tgttccattg tcttttgttt cttgagttgt gtcctttacg tgaatcggtt tagtctcctg 1430401 ctgtcttgtt gattcttttt caacattctg gccctgtttt ccttgttgat aggcacaagc 1430461 ggacaggata agtgtcagct gtatgataat gaaaagaatt cgcacttgcg ggttccctcc 1430521 ttaaaatgct ttcattaatt ttattgttga attaaccttc tatctttatg cacaaaaaca 1430581 tatattttag caggcattca cctttttcat caaaagagaa gcaggaagaa ctttgaccct 1430641 tatatcagga ggctgagact tgagtaaaat ttatgtgtta gatacgaatg tgttattaca 1430701 ggatcctaac gcgatatttt cttttgaaga aaatgaggtt gtcatccctg ctgtcgtttt 1430761 agaagaggtt gattcaaaaa aacggtatat ggacgaagtt gggaggaatg caaggcacgt 1430821 atctaagcta atcgatgcgc taagacaaaa gggcaggctg catgagcatg taccgcttga 1430881 caccggcggc acactgagaa ttgaactgaa tcatcgttcg tttcaccagc tgcaagagat 1430941 ctttattgaa aagacgaacg ataatcgcat attagccgtt gcgaaaaact taagcctcga 1431001 ggaagaaacc aaggaaaatg gcaggccggt tatccttgtc agtaaggatg tactggtcag 1431061 ggttaaagcc gacgcaatcg gactgcttgc tgaagatttc ttgaatgacc gggttgtgga 1431121 caatgatgaa atgtacagcg gctataaaga tttatatatc agccagcagc tgttcagctc 1431181 tttttacggg aaaaatcaaa tttcagtaaa cgatgtgaaa cagcatgcgt tttatccgaa 1431241 tcagtttgct ttaatgaagg atgagctagg agggtcctcc tcggcagtcg gaattgcaga 1431301 caaaaccgga acggtattaa aaagactcgt atttgatgat gaacatatat ggggaatcag 1431361 gccgaaaaat gtacagcaga caatggcatt agagcttttg ctgcgggaag atattccgct 1431421 tgtcaccctg atcggcaaag cgggaaccgg caaaacgctc ttagctttgg cggcagggct 1431481 attacagaca gaagacttgg gaatatataa aaagctggtc gtcgcaaggc cgattgttcc 1431541 tgttggcaag gacatcgggt atttgccagg cgaaaaagag gaaaagctaa agccttggat 1431601 gcagccgatt tttgacaact tagagtttct gtttaatgcg aaaaaaccag gggagcttga 1431661 tgctattttg gcgggaattg gctcaattca ggtagaggcg ctgacttata tcagagggag 1431721 aagcattcca gatcaattta ttatcattga tgaagcgcaa aatttgacca ggcatgaggt 1431781 gaaaacgttg ctgacgagag tcggtgaggg cagtaaaatt gtcttaatgg gcgaccctga 1431841 acaaattgat cacccatatt tagacagtct gaacaatggt ttggcctatg tggttgagcg 1431901 gtttaaagga caacccatct caggcagcgt gaagctgtta aaaggtgaga gatcaggtct 1431961 cgcccagctt gcagctgatt tgctgtaaca cttaaatgat ttcgatctct tttacatcgg 1432021 taatcggctg tttgtgatga accgggtctt caaagtaaat atgcacgggg ccgccttctt 1432081 gaatcggctt gcctgcctca ctgaaatgga caatactgtt cagagcggtt tccagagaaa 1432141 cggcggcctt tcccgaactt gtgacaaata cacattgtgt cgcagagctg ttcggctcag 1432201 catttttcag gacagtccca agtctcattg cgaaactgcc gttcatcagt ttttgcttct 1432261 catattgctt ttccgtcttt aatgtaggcg gcgcgattcg cccctctctg atgacgcgtt 1432321 ccggatcaag gtcggattca tccccggctg attgtaaata tgtgtcttga ctgtcccctt 1432381 tgcggtcaaa cgaaaatttg cgatcatcaa aaatccatac gcttggatca atggtaattg 1432441 gatatgtaac attgcctttt acttggataa cgctcatgat atgaccccct tctctcaaaa 1432501 ttataaaagt tttcgcatga attgtcactt tgtgtacaaa ttatgtgtat tgaaatgctg 1432561 agggaacgag ggtgtttgca tggtatgcca gcataatgat gagcttgaag ccttagtgaa 1432621 aaaggcgaaa aaagtaacgg acaaggggga ggtagccagc tatattcccg ccttggcaaa 1432681 agctgataaa cacgacctgt cagtggcgat ttattattcc aataatgttt gtctgtcagc 1432741 aggtgacgta gaaaaaacat ttacgcttca aagtatatcg aaagtccttt cccttgcttt 1432801 ggtgttaatg gaatacggca aagataaggt cttcagttat gttggacagg agccgaccgg 1432861 tgatccgttt aattcaatta tcaagctcga aacagtgaat ccgagcaagc cgttaaaccc 1432921 tatgattaat gccggggcat tggtagtgac aagtctgata aggggaagaa cggtaaaaga 1432981 gagacttgat tatttgcttt cttttatcag aaggctgaca aacaaccaag agattacata 1433041 ctgccgggaa gtggctgaat ctgaatacag cacttcaatg attaatcggg cgatgtgtta 1433101 ttatatgaag cagtacggca tttttgaaga tgatgtagag gcagtaatgg atttatatac 1433161 gaagcaatgc gcgattgaga tgaacagctt ggatttagcg aaaatcggat ctgtattcgc 1433221 attgaacggc agacatccag agactgggga gcaggtcatc tcaaaagatg tcgctagaat 1433281 ttgcaaaacg tttatggtga cgtgcggaat gtacaatgca agcggggaat tcgcaattaa 1433341 ggtcggaatt cctgcgaaaa gcggcgtatc cggcgggata atgggcattt cgccttacga 1433401 tttcgggatc ggcatattcg gccccgcatt agacgaaaaa gggaacagca ttgcaggtgt 1433461 aaagcttttg gaaataatgt ctgagatgta caggctgagt attttttaat ttatgtcata 1433521 tgcttaaatc ctcttgcatt ttctgttgat accctttatg ataaatagaa gaattaggta 1433581 ctcgcctggg gaacggaggg atacttttgg cttcagagat gatagttgac catcggcaaa 1433641 aagcttttga actcttaaaa gtggacgctg agaagatttt gaagctgatc cgagtacaaa 1433701 tggataactt aacgatgcct caatgtcctc tatatgaaga ggttttagat actcaaatgt 1433761 tcgggctttc gagggaaatc gattttgctg tccgcctggg attggttgat gaaaaagacg 1433821 gtaaagacct tttatacaca ttggagcgcg aattgtctgc tttgcatgac gcgtttacag 1433881 ctaaataaat gataaaactc aaacttatta acagtttggg tttttttata accgctattt 1433941 ttctctcatc tcataaaaga cggtcttttt ttacacattc cttccgaatc gtatagagat 1434001 tcttcgtctc gtttgataaa ttgtagtaaa ataaaaaaga taaatacata aaaaccatag 1434061 ataatggaag ttagaagcag ggaagaggat gttatgttaa aaaaaatgct aaaatcttat 1434121 gattactcac tgatattcgc aatcgtttta ttatgcggat tcggtttagt gatggtatac 1434181 agctcaagca tgattacggc tgtctcccgg tatggagtaa gcagtaattt tttcttcatg 1434241 cggcagctgt ttgctttaat tgcgggtggc gctctattta ttctcatggc gttgtttcct 1434301 tataaagcac tggcccatca aaagtttcag aaggggatac tgcttgtatc tgttcttgcg 1434361 cttatctcac tgtttgtttt cgggcatgtt gccggaaacg cgcagagctg gtttaaaatc 1434421 ggcggaatga gtattcagcc gggggagttt gtgaaactgg tcgtgatttt ataccttgca 1434481 gccgtatatg caaaaaaaca aagttatatc gaccatctgt taacgggagt agcccctccg 1434541 gtagtcatga cgcttataat ttgtgggtta attgccatgc agccagattt cggtacagcc 1434601 atgattatag ggttaattgc gacgtgcatg atcttgtgct ccggcttcag cggaaagacg 1434661 ctggtgaggc ttgtgatact gggcggaatt gttttcattt tagtcagccc tattatctat 1434721 ttgaatcagg acaaaatttt aactgaaggc cgtttagcgc gttttgagag tcttgaagac 1434781 ccatttaagt atgcaaattc atcaggtttg caagtgatca attcttatta tgcgatcagc 1434841 tcaggcggca ttttcggcct ggggctcggt gaaagtatcc aaaaatacgg atatctgcct 1434901 gaatcacaca ctgactttat tatggctgtc attgctgaag agctcggcat ttttggggta 1434961 ttgtttgtga ttttcttatt gggttttgtc gtcataaaag gtttttatat tgccagaaaa 1435021 tgcgaggacc cgtttggaag tcttctggcg atcggcattt caagcatgat tgccatccag 1435081 tcgtttatta accttggcgg tgtcagcgga ttaattccga ttacaggggt tacgctgcca 1435141 tttatcagtt acgggggctc ttctttggtg ctgctgctgg ggagtatggg gatattagcg 1435201 aatatcagca tgtttgtgaa atattcagag aataagaaaa agaaagagcc cttggcgccg 1435261 aagggaatga aaaagaaaca gctcaaaaaa actgtttatc tgtaaaaaac aagtgtgtac 1435321 aggggaagga tattccgcta tgatagatta tattccattc gggtaagggg gagaaaagtt 1435381 tgtctcagca atcgatacaa aaagtattag tagcaaacag gggagaaatt gcaatccgaa 1435441 tattccgggc gtgtaccgag ttgaatattc gtacagttgc ggtctattca aaagaagatt 1435501 ccggttccta ccatcggtac aaagcggatg aagcatactt ggtcggtgaa gggaaaaaac 1435561 cgattgatgc ttacctggat attgaaggta tcattgatat tgcgaaaaga aacaaagtcg 1435621 atgcaattca tccgggatac ggtttcttat ctgaaaatat tcattttgcg agacgatgtg 1435681 aagaagaagg catcgtattc atagggccaa aatccgagca tctcgatatg tttggtgaca 1435741 aggtaaaagc gcgtgagcag gcagaaaaag cgggaatccc cgtgattccg ggaagcgacg 1435801 gtcctgccga aacgcttgaa gccgtcgaac aatttggaca agctaacggt tatccgatca 1435861 tcattaaagc ctcgcttggc ggcggcggcc gcggtatgcg gattgtcaga tctgaaagtg 1435921 aagttaaaga agcatatgag cgtgctaaat cagaggcgaa agcagccttt ggcaatgatg 1435981 aagtttatgt agaaaaatta attgagaatc cgaaacatat tgaggttcag gtcattggag 1436041 acaagcaggg caatgtcgtc catctttttg agagggattg ctccgttcaa agacgccatc 1436101 aaaaagtcat tgaagtggcg ccgagtgtct cgctgtcacc tgaattaagg gaccaaattt 1436161 gtgaggctgc agttgcgctt gccaaaaatg taaactatat aaatgcgggg acggtcgaat 1436221 tccttgttgc aaacaacgag ttctacttta ttgaagtaaa tcctcgcgta caagttgaac 1436281 acacgataac agaaatgatt actggtgtcg atattgttca aactcagatc cttgttgccc 1436341 aagggcacag ccttcacagc aaaaaagtaa atattcctga gcaaaaggac atttttacaa 1436401 tcggctatgc cattcagtca cgggttacga ctgaggatcc gcaaaatgat ttcatgcctg 1436461 atacaggaaa aatcatggct taccgctcag gcggcggttt tggtgtccgt cttgataccg 1436521 gaaacagctt ccagggcgcc gtgatcacac catactatga ttcacttctc gttaagcttt 1436581 caacttgggc tttaacgttt gaacaggcag ctgccaaaat ggtgcgaaac cttcaggagt 1436641 ttagaatcag aggcataaaa acgaacattc cgttccttga gaacgttgca aagcatgaga 1436701 agttcctgac agggcaatat gatacatctt tcattgatac aacgcctgaa ttatttaatt 1436761 tccctaaaca aaaagaccgc ggaacgaaaa tgctcactta catcggcaat gtgacagtga 1436821 acggcttccc tggaatcggg aaaaaagaaa aaccggcgtt tgacaaaccg ttaggcgtaa 1436881 aggtagacgt tgatcagcag cctgccagag gaacaaagca aattctcgat gaaaaaggtg 1436941 cagaagggct tgcaaattgg gttaaggagc agaaatctgt ccttttaact gatacgacat 1437001 tcagggatgc ccaccaatcg ttattggcaa ctagaatcag atcgcatgat ttgaaaaaaa 1437061 tcgcaaatcc gacggctgcg ttatggcctg aactattcag tatggaaatg tggggaggcg 1437121 cgaccttcga tgtagcctac cgattcctga aagaagatcc gtggaaacgt ttggaagatc 1437181 ttcgcaaaga agtgccgaat accttattcc agatgttgct tcgctcatca aatgcggtcg 1437241 gctatacgaa ttatccggac aatgtgatta aagaatttgt gaagcaatca gctcaatccg 1437301 gtattgatgt gtttcgtatt ttcgacagct taaactgggt aaaagggatg acgttagcca 1437361 ttgatgctgt tagggatacc ggcaaagtgg cagaagctgc gatttgttat acgggagata 1437421 tccttgacaa gaaccggacg aagtacgacc ttgcatatta tacatcgatg gcgaaggagc 1437481 ttgaggcggc cggagcccat attctcggga ttaaagatat ggcagggctg ttaaaaccgc 1437541 aggctgcata tgagctcgtt tctgcgttga aagaaacgat cgacattccg gttcaccttc 1437601 atacgcatga tacgagcgga aacggtattt atatgtatgc gaaagctgtt gaagccggcg 1437661 ttgatatcat agacgtggcg gtcagctcaa tggcgggatt aacgtcacag cctagcgcga 1437721 gcggatttta tcatgcgatg gaaggcaacg accgccgtcc ggaaatgaat gtccaaggcg 1437781 ttgaattgct gtcccaatat tgggagtcgg tgcgtaaata ttatagtgaa tttgaaagcg 1437841 gaatgaagtc tccgcatact gaaatttatg aacacgaaat gccagggggc caatacagca 1437901 acctgcagca gcaagccaag ggagtaggcc ttggcgaccg ctggaacgaa gtcaaggaaa 1437961 tgtacagacg cgtgaacgat atgttcggtg acatcgtcaa ggtaacgcct tcctcaaaag 1438021 tagtcggaga tatggcactc tacatggtgc aaaacaatct gactgaaaaa gacgtttacg 1438081 aaaaaggtga atctttagat ttccctgatt ctgtcgtgga gctttttaaa ggaaatatcg 1438141 gccagcctca tggcggattc ccagaaaaac tgcaaaagct gatcttaaaa gggcaggagc 1438201 cgattacagt cagaccgggc gaactgcttg agccggtgtc atttgaagcg atcaaacagg 1438261 aatttaaaga gcagcataac ttggaaattt cagatcagga tgctgtggca tatgcccttt 1438321 atcctaaagt cttcactgat tatgtgaaaa cgacagaaag ctatggagac atctcggtat 1438381 tagatacacc gacattcttc tacggtatga cattaggtga agagatagaa gttgaaattg 1438441 agcgcggcaa aacgctgatc gttaagctga tttcaatcgg tgagcctcag cctgatgcca 1438501 cccgcgtcgt ttatttcgaa ctcaacgggc agccgcgtga agtagtcatt aaagatgaaa 1438561 gcattaagtc ttccgttcag gaaaggctga aagcagaccg gacaaatcca agccacatcg 1438621 cagcttccat gcctggaaca gttattaagg tattggctga agcaggcaca aaagtcaata 1438681 aaggtgatca tttgatgatt aatgaagcga tgaaaatgga aacaacggtt caggcgcctt 1438741 tctcaggaac aatcaagcag gttcatgtga aaaatggtga gccgatccaa acgggagatc 1438801 tgctccttga aattgaaaaa gcataaaaaa caaagagtgt atatcaatga tatacactct 1438861 tgttttttat atagaaaatg tggagtgaaa cagatggtta gaagagatat aaggggactt 1438921 cagagattat agagtactgt cacaagccca aaataaaaag aggcttatac agccaatatt 1438981 ttagatgctt tgtagtatgc cgtgcatatt tctttaagca ctatctgatt taaaaggctt 1439041 taatacttat gttcgcgagc tatagatcca tatgaaattt ctataatcac gatgagaaag 1439101 gggacagacc gaagtgagcc gctcactgat catcaagttc ggcgaaggct ggcgattgaa 1439161 acgcataaag cgccaaaaaa caagacataa aaaagaccaa agccgcctaa ggctttggtc 1439221 ttgagtcctt atgattgcct ggattcataa cggaaacgag caatcaataa taagaagtag 1439281 catagaacgc caaacagaca ggcaataaag aacgagtggg caagtgcaaa gcccagagcc 1439341 agttcagagt atacgatcat aataccggac agtgcctgta atgtaatgaa aataagacat 1439401 gagatccatc cccaaaagat ctgtttttga tctttatagg aagtaatagc atgaacagcg 1439461 gcaacaataa tccatacaaa taaaagtaag gctgctgctc tgtggcccat ttgcacccat 1439521 tcatggaatt gggtcggaag tccattgttc agcgggctgc acagcggcac attaggacat 1439581 gccagacttg attcagtgtg tcttacatat gcgcctgtat acacaacgat ataggaatat 1439641 attaaaattc ctatcatgtg aaattgcatc tttttgccga tttgaagcgg cttaaccagt 1439701 gttctgactg atttatcagc ttcaaatatg agcaatgtta aaataagcac tgaagcaaaa 1439761 gaaattaatg agatgccgaa gtgaagcgcc ataatcagcg cgttcgaacc gaatacgaca 1439821 gccaatgcgc caagcaatgc ctgaagaaat aaaaagataa ttgacatgat cgcgagaaac 1439881 gttgtttcac gaaaaatcgg cgtgattttt ctccatgacc aaaacgcaag gcttagcaca 1439941 aggataatag agattccgct tgcgaatcgg tggctccatt caataattga agccggattc 1440001 agttcaggga aaaaacggcc gtgacacagc ggccactgtc tgccgcatcc ttggccggaa 1440061 cctgtttttg taacgagggc acccccgatt aaaacaatta gcatgacaaa tgtcgtcaga 1440121 acaccgagag cttttaatgc tttattcata caatattcac cttcttaaca tactgctgca 1440181 attttatata cgttccaagt gtaagcgaat atgtgttttg tggcaattcc cagagccttt 1440241 tgttcacaaa aatataatag aatgacggct tctggaaaat gtacacttga ttattcatgc 1440301 cgggtctgat agaaataagg taaacgcaat gccgatttgg agattgcctt catctttggt 1440361 aaaattcata aaaagttcac aaataaattc ctgtttgtcg tttaatattt aataggatgt 1440421 ttttttacaa gatgttatct tgtatgatag agttgcaggt tattttattc tcctgcgtta 1440481 ggtttgtaag ggaggtttac gttatggcta actccagaat cttaaatgat acagctatag 1440541 acggacaaat tgaagaaaca acggcatgga aagattttct gtcccttatt aaaataggga 1440601 tcgtcaattc taacctcatc acgactttca ctggaatgtg gcttgcactg catatatccg 1440661 gtttaagttt tttaggcaat ataaacaccg ttcttcttac gttaatcggg tcttcactga 1440721 ttattgcggg ctcctgcgcg atcaataact ggtatgaccg ggacattgac catcttatgg 1440781 agcgtacgaa agtaagaccg acggttacgg gtaaaattca gccgagtcag gcgttatggt 1440841 ctggaatttt gctggttgct ttaggattga tcatgctgct gatgacaact gtcatggctg 1440901 ctgttatcgg ttttatcgga gtctttacgt atgttgtatt gtacacaatg tggacgaaac 1440961 gccgctatac gattaacaca gtagtaggaa gcgtttccgg tgcagtgccg ccgcttattg 1441021 gatggacggc agtggaaggg aatatcggtg tcgtagcatg ggtgttattc atgattttat 1441081 ttatttggca gattcctcac ttcttagcat tggctattaa gaaaactgag gattacagag 1441141 ctgcaaatat tccgatgctt cctgtcgtat acggatttga agtgacaaaa agacaaatta 1441201 ttgtgtgggt tgcgtgcctg atgccgcttc cgtttttcct tggtagcctg ggtcttccga 1441261 ttgtcattct cggcttgctg ttaaatatcg gctggctgat tcttggctta atgggattcc 1441321 gctccaagaa tatcatgaag tgggcaacgc agatgttcgt ttactcgctt aactacatga 1441381 caatctattt cgttgccatg gttgtcttga cgcttttcta aaaaatagat atgatgcttg 1441441 ttttatcgct tcaaaataaa cgatgacaac tagtaaatgc cgccttgacc tcttgtttaa 1441501 tcaggcggct ttacttttat acatagatgg cattttgagt aaaaaaactc ataatttaag 1441561 agaagaggaa atgtaagtgc tttattggtg ataggttgga tggcgataga tttcgatccg 1441621 ctttccgcct ttgtattgac cagaaaaggg gttgggtgaa atggtaaagc attggcgtct 1441681 tattttatta ttagccttag tgccgcttct attaagcgga tgtggaaaac cttttttatc 1441741 cacgctcaag cctgctggcg aggtggctga taaacagtat gacctgacag tgctcagcac 1441801 attgattatg gtggttgttg ttgcagtagt atctgttatc ttcttttatg tgattgtgag 1441861 attcagaaga tcacgggtcg gtgagaacac gataccgaaa caggtagagg ggaataaatt 1441921 tttagaaatc acatggaccg tgatcccgat tttgctgctc attattcttg tgattcctgt 1441981 tgtattatat acgctggagc tagcggacac atcaccaatg gataaaaaag gccgcaaagc 1442041 tgaggatgct cttgtagtca atgttagggc aaatttatac tggtgggagt ttgagtaccc 1442101 tgattacggc attatcacaa gccaggagct gattgtaccg acagatcagc gtgtatattt 1442161 taatttaaaa gcctctgatg taaaacattc cttctggatt ccttcagttg gaggaaaact 1442221 tgatacgaat acggataatg aaaataagtt cttcctgaca tttgattcaa aacgaagcaa 1442281 agaggcagga gatatgtttt ttgggaagtg tgcagagctt tgcggccctt cacatgcgct 1442341 gatggatttt aaggtgaaga cgatgtctgc aaaagaattt cagggctgga caaaagaaat 1442401 gaagaactat aagtctacag cagagagcga tttggctaag cagggtgaag aactgtttaa 1442461 agagaaaaac tgcctgagct gccatgcggt agagccgaat gataagcgtg cagaagccgc 1442521 tagaacggca cctaacttgg cgaccttcgg tgaaaggaca aaagtggcag gggtgaaaga 1442581 ggccaacaaa gaaaatgtga aggcttggct gaaggaccct gacagcataa agccggggaa 1442641 caaaatgaca ggcacatatc caaagctctc agacagcgaa acaaatgcgc tttatgaata 1442701 cttaaaaggc ttaaaagcgg aaagcaagta gggaagaaag ggagatattg ggggaggtca 1442761 catatgttga atgcgcttac agaaaagcgg acgcgcggat ctatgctttg ggattatttg 1442821 acgacggtgg accataaaaa aatcgcaatt ctttatttag tggcaggggg attcttcttt 1442881 cttgtcgggg gaattgaagc gatgtttatc agaattcagc ttgcaaagcc ggaaaatgcg 1442941 tttctcagtg ctcaagcgta caatgaagta atgactatgc acggaacgac gatgatcttt 1443001 ctggctgcga tgccgctctt atttgccttg atgaatgcgg ttgtgccttt gcagatcggg 1443061 gctcgggacg tttcgtttcc atttttaaac gcgcttggtt tttggctctt ctttttcggg 1443121 ggcattttct taaatctaag ctggtttttg ggcggagcgc cagatgcggg ctggacatca 1443181 tatgcctcac tttcgcttca ttctaaaggg cacggcatag actttttcgt cctcggactc 1443241 caaatatcgg ggctcgggac gctgatagcc gggattaact ttttggccac gattatcaac 1443301 atgagggctc cgggcatgac gtatatgagg ctgcctttgt ttacatggac gacatttgtg 1443361 gcctcggcat tgattttgtt cgcgtttccg ccgcttacgg ttggattggc tctcatgatg 1443421 ctggatcggc tgttcggaac caatttcttt aatccggagc ttggcggaaa tacggtcatt 1443481 tgggaacatt tattttggat cttcggccac ccggaggttt atatcctaat tttgcctgca 1443541 ttcggtattt tttctgaggt catccctgtg ttcgccagaa agcgtttgtt tggctattct 1443601 tcaatggttt ttgcaatcgt gctcattggc tttctgggct ttatggtttg ggtgcaccac 1443661 atgttcacga ctggtctcgg cccgattgca aatgcgattt ttgcggttgc aacaatggct 1443721 atcgcgattc cgaccgggat taagattttt aactggctgt tgacgatttg gggaggaaat 1443781 gtgaagtata caaccgctat gctgtatgct gtctcattta ttccatcctt tgtgctcggc 1443841 ggtgtgacgg gagtcatgct ggcagctgct gcggctgatt atcagtttca tgatacgtat 1443901 tttgtggttg cgcacttcca ctacgtcatt attggcggcg ttgtattcgg ccttttagcc 1443961 ggtgttcatt tctggtggcc gaaaatgttc ggtaaaattc tgcatgaaac gatggggaaa 1444021 atttcatttg tattgttttt tatcggcttt cacctcacgt ttttcattca gcattttgtc 1444081 ggcttaatgg ggatgccgcg ccgggtttat acgtttttgc caggacaggg tctggaaacc 1444141 ggcaacttga tcagtacaat cggggcgttt tttatggcgg cagctgttat tcttctgctg 1444201 gtcaatgtca tatggacatc ggtaaaaggt gaatatgtag gtgctgatcc atggcatgac 1444261 ggacgtacgc tggaatggac cgtttcttca ccgccgccgg agtataactt taaacagctt 1444321 ccttttgtca gaggacttga tccgctttgg atcgagaagc aggcagggca caaatcaatg 1444381 acgccggcgg aaccggttga tgatattcat atgccaaacg gctcaatcct gccgctcatc 1444441 atttccttcg gcctttttgt cgcagcgttc gggctgctgt acagaagtga ttacgcttgg 1444501 ggcctgccgg tgatctttat cgggctcggc atcacattta ttacgatgct gcttcgttca 1444561 gtaattgatg atcacggcta tcatattcat aaagaggaac tgccgaacga tgataaaggg 1444621 gtgaaggcat aatgcaagtt caagaaaaat tcaccgcaga aacctttcca gcttctcctg 1444681 aaaaagtaac cctggaaggg aaaaataaat ttttaggctt ttggcttttt cttggcggag 1444741 agactgttct gtttgcgtct ctcttcgcca cgtttcttgc gcttcggaat tcaaatgccg 1444801 gtgatccgcc tacgacggaa atgttcgatg tgacacttgt attcattgcc acaatgcttc 1444861 tattaacgag cagtttaacg agtgtgtacg cgatgtacca catgaagaac ttttccttcg 1444921 gcaagatgca gctttggctg ggaattacga ttttattggg ggcgggcttt ttaggactgg 1444981 aaatctatga gttcaagcat tacacccatg aatttggctt taccatcaca agctctgccc 1445041 ttggttctgc gttttacacg cttgtcggta cacacggcgc ccacgtggca tttgggctta 1445101 tgtggatcag cacgcttatg atccgcaatg ccaagagagg gctgaatctg tatacggcgc 1445161 ctaagtttta cgttgccagc ctttattggc actttattga tgtcgtgtgg gtcttcatct 1445221 ttaccgttgt atatttaatg gggatggtgg gataaacatg gtcgataaaa aaagcagagg 1445281 gcatatcaat agcgaccttg aatttaagaa aaaaaagcat gcccgggaga tgaaatatca 1445341 agtcctgtct tttggtttaa tgatcggtct tacgattgtt gcatttctga ctgtggccac 1445401 ggacggtgtc ggcagctggt ttacgattcc tttcattatt ttgctagctg caattcaagt 1445461 catttttcag ctgtattatt tcatgcatat gaatcagaaa gggcatgagg cgccggcact 1445521 gtttttgtat tcaggggtgt ttgtcgcgtt tatcactgtg cttgcgtttg tgacaattat 1445581 atggtggtaa tttgaacagc cgccggaggt gaagaaatga atcagttgga gatatttggg 1445641 tttcgcgcga tgtggagccc ttatcttttt tgtatcctgt taggcattac ggcgctttat 1445701 ctctattttt acaggcgaat gtcttcaaag ccgaatcgaa taactggtaa agagatggtg 1445761 tgctttctgt cggcgatgct gtttttatat gcagccgagg gaagcccggt tgatctgctc 1445821 ggacatatta tgttcagtgc gcatatggtg cagatggccg tcctgtattt ggttgtcccg 1445881 ccgctgttaa tcgcggggat tcctgcatgg ctctgggaaa aaatcatttt caggccttca 1445941 atcaaaccgg ttttttcctt ttttacgacg cctttaattg ctttgctttt gtttaacggc 1446001 attttttctt tatatcatgt accgcttata tttgatactg tcaaaacaga tccgttttac 1446061 catacattaa tcacttggct tatctttgtg cttgcgttct tcatgtggtg gccgcttgtt 1446121 cataaggttg agcgtctacg gcagctcagc ggcttgatga agctgggtta tattatggcg 1446181 gacggtatgc tgctcacacc tgcttgcgcc ttgatcatgt tcagcggtgc accgttatac 1446241 gccacctata cagatccggc tttatgggct gaggcaatga ggctttgcgt gccagcggat 1446301 atgatggggc aggtcccatt aacagggcca gagatgttga atacactgcc tttgttagag 1446361 gatcagcagc tcggagcagt catgatgaaa atcattcagg aaattgtgta cggtactttt 1446421 ttggccgtta tttttttcca atgggtgaag aaagaaaggg aaaaggacgg gcaggaggag 1446481 ccgccgtata ttcagcagac gatatcataa aaggtacagc gaaatatgct gtaccttttc 1446541 gttacatttg aactgttttt aacatgttgg ctatgtcctg aatcagtgcc ttgctttttg 1446601 tcacaacctg tacgggaaac tcttccgttt ctccatattc tactccatga gggtagtaat 1446661 gctttcctag gagaggggac attaattgaa tcacggcgcg cccgcttccg acatcgcctt 1446721 ctgccgcaat accttgtatc cgcaggtaaa acgtaccctc aatcgtcgaa aacttcttgt 1446781 cataggtgac tctctcgtaa tcccattgac ccgctctgat aagacctttg ctttccatta 1446841 agtcgtctag ccagctgagc tcagccttaa ccccttcaag tccgctttca gtaaacttca 1446901 acactgaccc ctccttataa aaattacctt tcctgacaat catagtatga aagcgttaaa 1446961 ctttcaatga atcttcttct tttgaaagta tgcaaaaatt aaattttgac gacaatagca 1447021 ctagactaaa ggaggttaaa cggatgacaa aaataaaaga tctgatgaca gccgacttgc 1447081 aatattgcac ggtattagat aatgtatatg aagctgcagt aaagatgaag gacgcaaatg 1447141 taggagcgat accggtagtt gatgaggacg gggaaacatt ggtcggcatc gtaaccgacc 1447201 gcgatctcgt attaagagga atcgccatca aaaaaccgaa ctcgcaaaaa atcactgacg 1447261 cgatgactga aaaacctgtc agtgtggagg aagatgcttc agtcgatgag gttcttcatt 1447321 tgatggcatc gcatcagctc agaaggatac cagttacaaa aaataaaaaa ctgactggaa 1447381 ttgtcacgct tggtgatctt tctttatctg agcaaacgaa tgaacgtgcc ggcagcgcct 1447441 tatcggatat ttccgaaggg gataatagag aagaaggctt ttttcattaa cacataaatc 1447501 tttgacatgt taaataggct gtattgtaat gggatgtaaa caagagattg tgaatcgcca 1447561 cgggggtgat agattgaaaa atatattgag agcaatggtt atccttttga ttatctgcgg 1447621 aacctatgtt ctgtttattc aatatggatc tgttcctgaa aagaaatcaa atgacagcga 1447681 gcctcaggtg tcgaatgagg aagcgcaaag cggcaaacga atacatatgc cgacttcagg 1447741 gttattgtcc ttcatgggca agcacgccga tgaagtaacg aaaaagcttg gggaacctga 1447801 acgtattgac ccttcggctt atgattacga ttggtgggta tacaatcaag gtaaggatca 1447861 atatatccaa atcggggtat taaacaataa agtggtcaca ttattcgcgt cgggtaatga 1447921 tattaacgcc aagcctttca aaattggaga atcaactggc gaagtattca agaccaccca 1447981 ggtggcacca tttgtgaatg tagagtataa aggaaattcc tatcggtttg aattttctga 1448041 agaagatatc aatacaagac cgactgtaaa ggtaggaaag atgtatgtcc agctgtatat 1448101 ggacaaattt gaggggaagc tatccagcat cagggcgttt gatgcgcaga cctttgtaaa 1448161 gcaaagacct tatgaggtag tgtaccgcgg ggaattaatt aaaccgaaag ccgtttcaga 1448221 tgagaaatgg aaaaagatcc aaacaacgag cgaaaagcaa atccttgatt tgacgaatgt 1448281 catacgcgtt aaacatggac ttgcgaagct tgagtgggat cagccaacgg cggaagtggc 1448341 atttgggcat agtgaggata tgaaggaaaa taattatttc tcccatgtct ctaaaaaata 1448401 cggctcgctg aaagaccgct tagaagaagg gcatgttgat tttcagcaag cgggagaaaa 1448461 tatcgcatac aattatgtgg acggtccggc tgctgtagaa ggctggctga atagcgaagg 1448521 ccatcgaaaa gcgcttctga attcagatta tacgcatctt ggtgtcggag tagaccggaa 1448581 atattacacc caaaacttta ttaagcgatg gtaatgaaag ccgcggacga atggttcccg 1448641 gctttttcta tttccataca agctggtctg aatgaatgtg ctgatagctt acagataagg 1448701 ccgtttccca tcccttcagt caggcttttt caccagtgta tagggatatc gctaaaaatt 1448761 catttgggaa tgaatatagg cgaacacaat gcccgacaaa acgatacatt gtagtaggta 1448821 acgattttcg gagggggtga ggattgtggc gaatcaacat gccaatcatt caatcaatga 1448881 ctttaaacaa ttcgtcaaaa agcatcccaa gctgataaaa gaagtgcgca aagaacaaag 1448941 aagctggcag gacgtatatg aaaattgggt cctcttcggg gagagcgacc cgatttggga 1449001 tccatatcgg gaaccggaag aagcttctga agctgtgcct gaaacaccgc aaaaaaatga 1449061 ttttgtctcg aaaatggtga cagcggtgaa aaagatggat gtcaatcaaa tgaacgaaca 1449121 aatcaataaa atgagccagt cgatctcatc gttgcaaagc cttcttaata cattttccgg 1449181 aagcggacag aagcattctc agccaggctc tggacagcat cctttttctt ttcgaaagga 1449241 ttaaaaaagg ggagctcata tgcgcaaaga ggttcaggaa tatattttag caaacgaaga 1449301 acggaaacga ttcatcagag aacagccgat atggtaccgc aggctttcaa gaaaaccgga 1449361 tgatctgtcc tcctttcagc ttgaaatgat gaatttttat gaaaaaacca ttccgcatcg 1449421 ggtgaatcag tttacgaacg ggattcaaat ggcgcaaatg atgatgcaaa tgtttcaagc 1449481 gatgcggaca aaagattaaa aggccccgaa gaagggtctt ttttcatgcg gtcataaggt 1449541 tttgttggcg gctgcggtta agcattttcc aattggctgg tttcatggta aactaacaac 1449601 tggaggtgca tgttatgtat gcgacgatgg aatccgtgcg gcttcaaagt gaagctcagc 1449661 agcttgccga gatgattctg cagtcggaga cggctgagaa ctaccgcaat tgttacaagc 1449721 gtctccagga agatgaagag gcaggtcgga ttattcgttc ttttatcaaa ataaaagagc 1449781 agtatgagga tgtacagcgt tttggcaaat atcatcctga ctatagagaa atatcccgga 1449841 aaatgaggga gatcaaacgt gagctggacc tgaacgataa ggtggctgac ttcaagagag 1449901 ctgaaaatga gctccagtcc attcttgatg aggtcagcgt tgagattggg acagctgttt 1449961 cggagcatgt gaaagttccg actgggaacc cttattttga cggtttgtct tcatgcggag 1450021 gcggctgcgg ttcaggcgga agctgcggat gtaaagtgtc ctgacgagac tggccgtctc 1450081 gtcttttaca tataagagaa aacaggcagg tgattgtatt ggagaatagg cgccagggca 1450141 tggttgtgta tctgcactcc ctaaagcaga gcaaaatgct gaggaagttc gggaatgtgc 1450201 actatgtatc aaaacgatta aaatatgtcg tactgtactg tgatatggac caaattgaaa 1450261 aaacaatgga caagattgcg tcttactcat ttgtgaaaaa agtggagcct tcttataaac 1450321 cgtttttaaa attggaattc gagtcaaagc ttgataaggc aaaagaatac gattataaaa 1450381 tcggcatata gctataaaaa aatccccgca ggcatctgcg gggtccttct attccttaat 1450441 atgttaagga gaaggcaaag ggagaggaga aaccggagga agaacttatg gggaaacgta 1450501 agtcttctcc gcggttggca acaacatcct ctagatgctg ttgcttatag tatggacaag 1450561 gatcatgctg cctatacacc tgtttatcaa gattagcgtt cattgtttgg aagaatgctt 1450621 tatgttaaga taggattgat ttttttctat gtacatagcg gcgtccggcc gaataaagaa 1450681 acaaaatagc ttttagaaaa agtggtgtgg aacatgagag taatttctgg atcaaaaaaa 1450741 ggccgttcac taaaggctgt agccggaaca tcaacaagac cgacaaccga caaagtgaag 1450801 gaatccattt tcaatatgat cggcccttat tttgacgggg gcaggggact tgacttattc 1450861 gcagggagcg gaggtcttgg aatcgaagcg ctttcacgcg ggtttgagca ttgtatattc 1450921 gttgaccgtg attttaaagc gattcaaacg gtaaaatcta atttgaaaac gctggagctt 1450981 acaaaacatg cacaggtata ccgcaatgat gcggaacgtg ctttgcacgc tgctgctaaa 1451041 agagaaaccg gctttcgcgg aatttttctc gatccgccgt ataaggaaca aaagctgaaa 1451101 gcacttttaa ctttgattga cgaatatcaa atgctggaag aagacggctt tatcgtcgct 1451161 gagcatgaca gagaggtcga gcttcccgaa accgtaggag atcttgtgat gacaagaaaa 1451221 gaaacctatg ggttaacagg tgtagcgatt tataaaaaga gggggtagtg aggtggcgag 1451281 tatagctgtc tgtcccggca gttttgatcc tgtgacctac gggcatctgg acatcatcaa 1451341 acgcggggcg catatttttg aacaagtgta tgtatgtgtg ctgaataatt cttcaaaaaa 1451401 gcctttgttc agtgtggaag aacggtgtga gcttctgaga gaagtcacaa aagacattcc 1451461 gaacataaca gttgaaacat cgcaaggcct gttaattgat tatgcaaaaa gaaaaaatgc 1451521 gaaagcgatt ttaagaggct tgagagctgt atctgatttt gaatacgaga tgcaggggac 1451581 atcagtaaac cgggtgcttg atgaatctat tgagacgttt tttatgatga caaacaatca 1451641 atattcgttt ctaagttcaa gcatcgtaaa agaagtggca agatacaacg gctcggtatc 1451701 agagtttgta ccgccggaag tagagttggc gcttcagcaa aaattcagac aaggatgagg 1451761 gttttgactc atcctttttt tgttccgttt gtcagtctgt aagaaaaaat gataatgtac 1451821 gtaaacagcg cgcatagtgt gacagcaggt ccgatctgca caagcagatt ccagccgttt 1451881 ataaaggcag ttgacatgtc actgctgtta agagatttaa atacatactg atacggatca 1451941 tgccatgctg tgtaaagagg tttccataaa agcatgacga agacagcggc ataaacgccc 1452001 tgcagcaaac gtgcgataaa gaatggttta aatctaatgt cggtttccga taaaatacct 1452061 gccacctgag cttgtacgga aaagccgcta aacccaagaa taaagctgac gataatggct 1452121 ttttgcagaa gagaaacatc tgtctcgctg acaagcttgc tgcctaatgt aatttcaaac 1452181 atccctgata aaagcggaat gtccaattga gtcggaagct gaaacaaagt cagtgctcct 1452241 tttgtgaaaa cagacaaaac atcagtcagc tggaccactg acaacagccg attgaagaca 1452301 gaaaataaaa taataaagcc gcctaccata agaagcgttt gaacagaaga cgtcacggcg 1452361 tcgcctaaaa ttttacctaa gggccgtttt tctgcaagtc tggcggtatg aagagcgtgt 1452421 aaagcatctt tgactgaagg gaaaggtatc gttttctttc ttctgagatg ctgctcttcc 1452481 ttgcggccat aggagcgcat tgttaaaccg acggcaagat tccccaaata gtgtgcagaa 1452541 gctaataaaa tgcctagtga tgcgttttga aagaaaccga cggcaacagc gccgaaaata 1452601 aagagcgggt ttgaagaatt ggtaaacgac gcgagccgtt ctgcctctac tcttgaaatc 1452661 tgattttcct gccgcagacg ggcagtgagt tttgcgcccg ctgggtttcc tgatgccatt 1452721 cccatagcaa gaacgaagcc gccgacaccc ggcacgcgaa agatcggccg cataaaaggc 1452781 tcaagcaaaa caccgacaaa ccgcacaatg ccaaagccga ttaagagttc ggacagaata 1452841 aaaaatggca gcaatgacgg aaacacaacc tcccaccaca tagacagccc ggttttagag 1452901 gcttcgaatg aggcctgtgg atgtgagatg acagtcgctg ttaaaaaaag aaaaaacgag 1452961 gcaatcaaaa gtgtattaat cttcgacaag ttcattctta cctccccgat gctaaaaatg 1453021 cccaatgaca tgtatatcat gataaaataa tgtatgatgt aaaacggcca agcagtacct 1453081 gtcctcttga ttctttgtac taatatacga gcataggggt tcagtttaga ccatagaatt 1453141 cggtatacag ggaattcagg caggaggtta acgctttggc caaacctaaa atcgggttag 1453201 cgttaggatc gggaggggcc agagggcttg ctcatctcgg tgtgctttcc agtttacata 1453261 agcaccaaat tgaagtggat atgattgcag gaagcagcat gggcgctttg gtgggcagtt 1453321 tttacgccgc cggacatgac gtggcaacga tgaaaaaagt agccaaagcc tttaaacgaa 1453381 ggctttatgc tgattatacg gtgccgaaac tcggtttttt aaaaggtgac cgcgtcagac 1453441 agcttgtgca tgcttataca ttcggaaaac cgattgaaga gctccaaatc ccgctgggca 1453501 ttgttgcgtg tgatctacag acgggagaaa agattgtgtt ccgaaaagga tcagtgtcag 1453561 atgcagtgag ggccagcatc agcatcccgg gtatctttat tccgcagcgg ctggacggac 1453621 gccttcttgt agacggcgcg gtcgtcgatc gaattccggt ttctgttgtg aaagacatgg 1453681 gagctgatat tatcatcgct tcggatgttt ccagggttcg aaaaactgaa acagcagtgc 1453741 atatttttga tgtgattatg caaagtatgg atatactgca aaatgaatta gtgcggcatc 1453801 aaacaattgc cgcagatatc atgattcgcc cttcccttga aacatacagc tcaagctcgt 1453861 ttgccaatat tgaagaaatg atatcggcag gcgaagaggc gacaaaccga atgatcagca 1453921 agataagaaa agaaatagag aattgggagg gctcataatt tgctacgtaa aaaacatttt 1453981 agctggatgc tcgtcatcct catactgatc gccgttttat catttataaa acttccatac 1454041 tatattacaa aaccgggaga agcgacagag cttgcttcat tgataaaagt ggagggaggc 1454101 tacccggaaa aaggaagtct gtccttaatg actgttaaag tgggaccggc taatccattt 1454161 acatatgtgt gggcaaagat gcacccttat tatgaaattg ttcctgatga gagcattaag 1454221 gaggaaggcg aatcagataa ggagtatatg aaaagacagc tccaaatgat gaaaagctcg 1454281 caagaaaatg cggttatagc cgcctatcaa aaggcaggaa aaaaagtcag ctattccttt 1454341 aacggcatat acgcaagctc agttgtagaa aacatgccgg caaaagggaa aatagaagtc 1454401 ggtgataaaa tcatcagcgc agacggcaaa aactatcagt ctgctgaaaa gctgattgat 1454461 tatatcagca gcaaaaaagc gggagataaa gtcacgttaa agatcgaaag agaagaaaaa 1454521 gaaaagcgtg tcacccttac gttaaaacaa tttcctgatg agccggatcg ggcaggaatc 1454581 ggagtttcgc tttatacaga cagaaacgtg aaggtagagc ctgatattga ttttgaaatc 1454641 gaaaatattg gcggcccgtc agcagggtta atgatgtccc ttgaaatcta taatcagctg 1454701 acaaaaccag acgaaacaaa aggctacgat attgcgggaa caggtacgat tgatgttgac 1454761 ggaaaagtag gcccgatcgg cggcattgat caaaaagtcg tcgccgcaga caaagccgga 1454821 aaagacattt tcttcgcgcc aaatcaaaac ggcgccagca attccgatta taagaacgca 1454881 gtaaaaacag caaaagatat tgattcaaat atgaagattg tgcctgttga taccatgcag 1454941 gatgcgattg attatttgaa taagctgaaa gcgaaaagca cctgattctc aggtgctttt 1455001 tctatacatt taaaaagtgt tgttcatctt cgtcatatcg aatcggtgca tgtccgtatt 1455061 cctgtaggtc aaactcagtt ctcagcggct cttctatcgg caggctgtaa atcctgcttg 1455121 cttttacgtc cagatcgaga gctggatggg agaaagagga cagtttgctg acaagcggaa 1455181 cagacagtgc ttttttcttt tcggataaat aagcctgtcc ttttttcgtc atgccgagaa 1455241 gcctgatata cggcgcctta tcgttgtcaa gcagcttttg catatcctgt ttttttgttc 1455301 tggttaaaat gtgtgtattc atccgctgga gccttgtcca cgtatagcgt tttgttttca 1455361 gcagttccat aaattcctga taggagctgg attttctgat cgaacgaata attctgtgct 1455421 ctaaaccttc ctccacctcg tatacttgct gtaattcccg tgccgttaca gttgaaaggc 1455481 tgtattttaa gtaagaaaag tagctttcag gtgtatgcca caatccgaaa gatttgcggt 1455541 aagctgctaa ttcacgtgca gatgcagcag ggagaaaacg aaggcaggct tcgagattct 1455601 ggccaatcat cgcttttcta atgcttgtgg cacttgctat atggttttcg ccttcaggga 1455661 gatcggcatc atgatagtcc gaagagattc gtgccgtagt ataaggtttc ataggatatc 1455721 ccccggttag aatcgaggtc acatactggt atcccaaaat gttatttggt tttgacaagt 1455781 caagtgcact ttcagtatgc aaaatggagc tgaaggcgat agccgccgct gctgggtaac 1455841 tggccccctt tttaagttct tctttaattc ggtcattcaa tatatgttta tgctcatcaa 1455901 taagctgtgc tgtttctaaa aaaggcttga tatccccatt ttcactcccg aaaaacagcg 1455961 cctcacattc aagttcgttc aggatggaaa cactgccgcg tgcaaaaatg tctgcttttt 1456021 gcacggcata aagataaggc agctcaatga caagatcaac tccgctttgc agcgccattt 1456081 ttgttcgggc ccattttgat acaacagcgg gttccccgcg ctgtaaaaaa tgtccgctca 1456141 tgaccgcgac agccgtgtca catccggttt gcagctttgc tgtttgggca tgataaaggt 1456201 gaccgttatg aaagggatta tattcaacca ccaatccgac agctttcata ttttttccgc 1456261 ctttcttgct atgtttaaaa acgtatggta catttgcaaa tgaaaactct tacgccttat 1456321 ttttgtttta agtgtatgca tagcatattc cgctgtcaac gatacttcaa tggcagcatt 1456381 atgctgtaaa gaaaaaatat tgacaaaaac aatcttaaaa gctataatca tgtttgttgc 1456441 tttcctgagg tgatacaaat gaaatggacg atttatcagc tgcatcaaat gccaaaacaa 1456501 agttttgagt ttgatgaaac agttgagtta aatgagctga caaagctgaa ttctgacatt 1456561 cgccgcattt ctcccgttcg ggtgaagggc agagcggata tcaaatccaa acaggtttcg 1456621 tttgatttta caatttcagg cgaaatgctt ttgccatgct caagaacact cgttgatgtt 1456681 ccgtatccat ttgaaatttc aacaaaagaa ctgtttatat ttcatcacac ggatgatata 1456741 gaagatgatg acgttcacat tgttgaggac gatactatcg acataactcc gatcgtgaaa 1456801 gaagaaattc ttttagaaat ccctatgcaa atcttttgtg aatctgaaca agaaaaagga 1456861 gctgctcctc aagaaggaaa ggattggcaa gtcatttcgg aagaagacaa gaagaatcaa 1456921 gttgatccga gacttgcagc ccttgaaaag ctcttaaaac aagatgatga atcttaactc 1456981 tttaaggagg tgggaataat ggctgtacct tttagaagaa cttctaaaat gaagaaaaga 1457041 ttgcgccgta cacatttcaa acttaatgta cctggtatga cagaatgtcc gtcatgcgga 1457101 gagatgaagt tgtctcaccg tgtatgcaaa gcatgcggat catacaacgg caaagacata 1457161 aatgtaaaaa gtaactaatg agaaaagcgc agggtgaaag ccctgcgctt tttctttttc 1457221 tcttcctgtc agcttgcgga aaatttgtga gtgcaaatag tctatctaat ctattaccgg 1457281 catatgtatg agataaataa gctgacatgg agggagattg aatttgacca ttacaagaca 1457341 agatgcttgg actcaggatg aggatttgct gctggcagaa gtggtgcttc gtcatattcg 1457401 agagggagga acacagcttt cagcctttga ggaggttgga agggcgctga ccagaaccgc 1457461 ggcagcctgt ggtttcaggt ggaactcgta tgtgagaaaa caataccagt caggtataga 1457521 gcttgcaaaa aagcaaagga aagaactgag aaagcaaatc ggcgttcatt cggtcaatat 1457581 gccgaattcc atgaagcaga ctgcctcggc atcgtcagaa ggaaaacgag atttgtccat 1457641 tcaggatgtc attcaatttc tcgaacaatt caaagaaaca ccgtctgcac aagaatttca 1457701 gcttgaaagg gaaaaattga aggagcaaat ccaatcgctg caaaaagagc ttgaggattt 1457761 gcggagtgaa aatcagacat tgcggaatca gctagagatg acagaagagg attacaaggc 1457821 actgatcgat atcatggatc gggccagaaa aatggttgtt tcgaaggaag acggaagaat 1457881 gaaaaaagcg gctcaagaaa cgtaaagaaa cgcctgaaat gaaccggccc tatagtaaga 1457941 ataggccggt tgttttgatt tctatgcaga ctctcccggt gtcatttcgc gatccatatc 1458001 aggatgccag atgagcgggt tttccccttt gtcccgcgcc atatcatact taacagtttt 1458061 aaagttcatt ttgttccaaa attccgctga tttcattctc ggatttgtcc ggatcggcat 1458121 tttgaatgat tttgcaaatt caaccaaggc tctcccgtat cccctgttct ggtagcccgg 1458181 aagaacctca agcttccaca gctccaaata atcctggcgg ttgtcaaaat agggattcga 1458241 tttgccgtta acttgataca gactcattcg tgctacaagt ttatcgccaa aataaatccc 1458301 gtaaaaaggc gaggtgctgt cattttcaat aatattatcc tgaagttctt caagcattga 1458361 aagctcctga atgccgtatt ctttgaattt cttgaattct tccagcgttt tatagttgat 1458421 aagcagacgt tctacctttg tcaaacaaat ctcccccttt gttgtttcta catatattgt 1458481 aaacgcttta tttaaaaaat ccaaatattt aaactttaat tttaagcaca tgggatcttt 1458541 gagaagtaat ttcttcttac ttctgctatg ataatacgta aatgctaaat tgggtgtgac 1458601 atcatgaaaa ttggaattat cggcggaggc tccgttggtc ttttatgcgc ctattatttg 1458661 tcactttatc acgacgtgac tgttgtgacg aggcggcaag aacaggctgc ggccattcag 1458721 tctgaaggaa tccggcttta taaaggcggg gaggaattca gggctgattg cagtgcggac 1458781 acgagtatca attcggactt tgacctgctt gtcgtgacag tgaagcagca tcagcttcaa 1458841 tctgtttttt cgtcgcttga acgaatcggg aagacgaata tattattttt gcaaaacggc 1458901 atggggcata tccacgacct aaaagactgg cacgttggcc attccattta tgttggaatc 1458961 gttgagcacg gagctgtaag aaaatcggat acagctgttg atcatacagg cctaggtgcg 1459021 ataaaatgga gcgcgttcga cgatgctgaa ccagaccggc tgaacatctt gtttcagcat 1459081 aaccattcgg attttccgat ttattatgag acggattggt accgtctgct gacgggcaag 1459141 ctgattgtaa atgcgtgtat taatccttta actgcgttat tgcaagtgaa aaatggagaa 1459201 ctgctgacaa cgccagctta tctggctttt atgaagctgg tatttcagga ggcatgccgc 1459261 attttaaaac ttgaaaatga agaaaaggct tgggagcggg ttcaggccgt ttgtgggcaa 1459321 acgaaagaga atcgttcatc aatgctggtt gacgtcattg gaggccggca gacggaagct 1459381 gacgccatta tcggatactt attgaaggaa gcaagtcttc aaggtcttga tgccgtccac 1459441 ctagagtttt tatatggcag catcaaagca ttggagcgaa atacaaacaa agtcttttga 1459501 gctttttcgg taacatgcta tactcatttc ggatcactaa ctatttattg gagaaaggaa 1459561 gttctagaag atgcagctaa ctgaactttc catcaaaaat cagaatgtgt ttgtacagca 1459621 ctatatagat ggcaaagaag aaatgtcttc tttttttgat tacagtattc atcataagga 1459681 catgtggcgc gaaagactgg aagacttatc ttcccggttt ttcgcaagag aggaattggc 1459741 ggcgtactta acctcttacc ataataaatt cggttcaagt gcgatgcagt ctgctattga 1459801 gaagctgaag gacccgtcaa gtgccgctgt agtcggcgga cagcaggcag gacttttaac 1459861 aggaccgctt tacaccatac ataaaatcat ttcaatcatt gttttagcaa agcaacaaga 1459921 aaaggaactg caagtgcctg tcataccaat cttctgggtg gctggagaag accacgattt 1459981 ggatgagatt aattttgttc acacatctga agagaatggg cctgtgaaaa aaaagctgcc 1460041 tcagtcttat tggaagaaat catcagcagc gagtacatcg cttgatcagg aaaagtgtgc 1460101 cgcgtggata gatgatgttt ttgccgcttt tgaagaaaca gaccatacga atacacttct 1460161 cgacaatgtg aaacgatgtt taagggaatc tgttacgttt actgacttct ttgaactgct 1460221 gatcgcggat ttgttccaag aagagggctt agttttatta aattctgggg atccggggat 1460281 taaaaagctg gaaacggcca tgttccaaaa gattcttcga gaaaatgatg aactcgcccg 1460341 ggctgtatca gatcagcagg ccttcatgcg tcaagcaggc tacaaaccga ttatcgagtc 1460401 cggaaaagag caggcgaatc tgttttatga atacgaagat gagcgttttt taattgaaaa 1460461 agataacggc cgatttgtca tcaaagagct tgatctagga tggacgaggg atgaacttca 1460521 tacacatatg gaagaacatc cagagcgttt cagcaacaat gttgtaacga gaccgttaat 1460581 gcaggaattt ctcattccga ctttagcatt tattgcaggg cctggggaaa tcaattattg 1460641 gggcgagctc aaacaggcat ttgcggtgat gggcttcaaa atgcctcctg tcatgccaag 1460701 gctgaacatt acgatacttg agcggcatat tgagaaaaaa ctggctgaac ggaatatctc 1460761 attacaagac gcgattgagc gcggaacgga gaatcaaaga gagacatact tcgagcgcca 1460821 gattccggaa gagtttacgg cggtgatgga tcaggcgaaa agccaaattg aagcgattca 1460881 caaaacggtc cggcaggagg cgttaaaggt tgatcaaagc ttggaacctt tacttctgaa 1460941 aaatgccgct tttattcagg atcagcttca attcttagag cgcacggtga tgaagcgaat 1461001 tgaagaaaaa gaaggctacg tcttgaagga ttatgaaaga attcaaaata gcattaagcc 1461061 gcttcttgcg ccgcaagaac ggatttggaa tatcatgtat tatttgaaca ggtacggtcc 1461121 aaaattcttc acgacattca agaatctgcc attttctttt caaaatcaac atcaagttgt 1461181 caaactttga aataaagttt taaagaaccc tgactagttc agggtttttt tttatgggta 1461241 aacagtgtaa aatgaagttg tggagcgaag tggtgaatag tggtgagtta aggagagaaa 1461301 gtggggcaag agatcatgtt tatgggtgaa tatcagcata ccatcgatgc gaaaggccgc 1461361 atgatcgtac ccgctaaatt cagagaaggc ctaggtgagc aatttgtgct gactagagga 1461421 cttgaccaat gtctcttcgg ctaccctatg cacgaatgga aacaaattga agaaaaacta 1461481 aaagctcttc ctctcacaaa gaaagatgcc cgcgcgttta cccgtttctt cttttcaggg 1461541 gcgactgaat gcgaactgga taagcaaggc agggtaaata tcgcatcatc tctattgaat 1461601 tacgccaaac tggaaaaaga atgtgttgtt atcggggttt ctaatcgaat tgaattgtgg 1461661 agtaaagtaa tttgggaaca atacacagaa gagcaagaag attcatttgc tgaaattgct 1461721 gaaaacatga ttgggtttga tatataatga ttcttcgtgt ataacactct aaaaacaatt 1461781 tcaattcatc ctgataaaag gtgggaccaa cacaatatgt ttcaacacaa gacagtactt 1461841 cttcgtgaaa ccgtagacgg acttaatatt aaaccagacg gtacatatgt agactgcaca 1461901 ctcggcggag ctgggcatag tacatactta ttgcagcagt tatccgagaa ggggcgttta 1461961 atcgcttttg accaagatga tacggcatta cagcatgcta aagaagtgtt gtccgattat 1462021 aaaggacagc tcattctgat taaaagcaat ttcaggtatt taaaagaata tttgaatgaa 1462081 caaggcgtta cagaagtaga cggcatttta tttgatttag gggtgtcctc tccgcagctg 1462141 gatacaccgg agcgcggatt cagttaccat catgacgcac cgttggacat gaggatggac 1462201 cagtcggcta cgctttcggc gaaagaagtc gttaatgagt ggcgctatga ggatctcgtc 1462261 cgtattttct ttaaatacgg agaagagaag ttcagtaaac agatcgccag aaaaattgag 1462321 gaggcaagaa tgaagtctcc tattcaaact acgggccaac tggtcgatct aataaaagac 1462381 gcgattcccg ctccagcgag aaggagcggg ggacatcccg ctaaacgcgt gtttcaggca 1462441 atcagaattg ccgtaaacga tgaacttagg gtgtttgaag aagctttgga gcaggcaatt 1462501 gaggttctga agccaggggg cagggtatcg gtcattacct tccactcgct agaagacaga 1462561 atttgcaaaa ccacttttaa agaaaagtcg tcgcttccgg aacttcctcc gggacttcct 1462621 gttataccgg aagagtttga accggagctg aagctcatca cacgaaaacc gattacggca 1462681 tctcaagaag agcttgaaga gaacaaccgg gctcgttctg ccaagcttcg gattgctgaa 1462741 aaaagaaaat aacgaaacgc gaacgcaaaa ttaaaaggag gtcatcagcc tatgagcaat 1462801 ttagcttacc aaccagagaa acagcagcgg catgcgatca gtcctgagaa aaaagtgatt 1462861 gtcaagaaaa gggcttccat tactctcgga gaaaaagtgc ttcttgtcct ctttgctgcg 1462921 gcggtgctca gcgtatcgct tttgatcgta tcgaaggcgt atgcggcata tcaaaccaat 1462981 attgaggtgc aaaagcttga ggagcaaatt tcatccgaaa ataagcaaat tggtgacctc 1463041 gaaaaaagcg ttgctgattt aagcaaaccg cagcgcatta tggacattgc gaaaaagaac 1463101 ggcttgaatt taaaagataa aaaagtgaaa aacatacagg aatgattcaa atgccaaaaa 1463161 agaataaatt tatgaataga ggagcagcga ttctaagtat ttgtttcgct ctctttttct 1463221 ttgtcatcct ggggagaatg gcatatattc aaataaccgg aaaagcgaac ggcgaagtgc 1463281 ttgcgacaaa agcgacagag cagcatgaaa agaaacggac catcgaagcg agccgcggct 1463341 cgattttaga ccgaaaagga aaagtcattg cagaggacac agcgacgtat aaactgattg 1463401 cgattctcga taaaaaaatg accactgatg tcaagcatcc tcagcatgtt gtaaacaaag 1463461 aaaaaacggc ggaagcattg tctaaagtga taaacttgga caaggccgac atccttgata 1463521 tcttaaataa agatgcaaaa caagtcgagt ttggctcagc tggccgggat attacgtatt 1463581 cacaaaagca aaaaatcgaa aaaatgaaac tcccgggcat ttcattttta cgggatacaa 1463641 aacgctacta tccaaacgga gtatttgcat ctaatctaat cggctatgcc gaggttgatg 1463701 aagaaacaaa tgaaatttcc ggcgcgatgg gattagaaaa agtgctggat aagtatttga 1463761 aggagcggga cggatatgtg acatatgaaa gcgacaaatc cggctgggag ctcccgaaca 1463821 gcaaaaataa aattacagcg ccaaaaaatg gtgacaatgt atatttaacc attgaccaga 1463881 aaattcaaac ctttttggaa gacagcatga caaaagtggc gcaaaagtat aatccgaaaa 1463941 aaatcatggc cgcagtcgtt gatccgaaaa cgggcaaagt ccttgccatg ggacagcgcc 1464001 caagctttga tccgaacaag cgcgatgtga caaactacta taatgatttg atttcatatg 1464061 cgtatgaacc cgggtccacg atgaagatct ttacactcgc tgctgcgatg caggaaaacg 1464121 tgtttaatgc gaacgaaaaa tataaatcag ggacatttga agttggcgga gcacctgtta 1464181 aggatcacaa taacggtgta ggctggggtc cgacaacata tcatgacggc gtcctaaggt 1464241 cgtcgaatgt cgcttttgcg aaactggcga aagaaaagct gggatatgac cgcctcaatc 1464301 aatatttgca caaattcaat ttttaccaga aaacaggtat tgatttgcca ggagaagtct 1464361 ccagcaaaat caactttaaa tatgaatttg ataaggcgtc aactgcatat ggccaagcgt 1464421 ctgcggtcac accaattcag cagattcagg ccgcaacggc aattgcaaat gacggtaaaa 1464481 tgatgaaacc ttatgtcatt gaccatatcg ttgaccctga taaagataaa actatttatc 1464541 aaaataagcc ggaatcagcc ggaactccaa tttctgcaag tactgcgaaa aaggtgcggg 1464601 atatattagg agaagtcgtt acatcgaaga tcggaacagg gcaagcttat aaaatcgaag 1464661 gttttgatgt tgccgggaaa acaggtactg cgcaaatagc cggtaaaggc ggatatttag 1464721 acggcacaga taactatatc ttttcgttta tgggtatggc gccaaaagat gatcctgagc 1464781 ttttaattta tgttgctgta cagcagccgc aactaaaagc aggacaaagc agttcagatc 1464841 cagtatcaga aatcttcaat ccaacaatga aaaatagcct gcactaccta aacatcgaac 1464901 caactgaaaa atctgactca gataaggaag aaacaaaagc gcagacaatg cctgatttaa 1464961 cagatcaaac ggtagctgct gctcaaaaga aagcaaaaga ggagaatctc acaccaattg 1465021 tcatcggcag tgatgtcgct gtaaaagaac agtatccgaa agcggatgag gaagttctca 1465081 ccaatcaaaa ggtcttcctg aaaacgggcg gcaaaatcaa aatgcctgat atgacaggct 1465141 ggtcgagaag agaggttctg cagtacggcg agctcgcggg aattcatatt gaagtaagcg 1465201 gacaaggcta cgctgtcagc caaagtgtta agaaagacaa agaaatcaaa gacaaaaccg 1465261 taatcaaggt taagtttaaa aatcctgatt aaaaagaaag ccgtcgttat gcaggctttc 1465321 tttttttatg ccttcagagg agcatcgttc tacctgtcca aattcaggca taaaatgaaa 1465381 caagcctaaa taaggagtga acggtctctt gcgcgtctcg aatgtaacgg ttagaaaacg 1465441 tttattattt gttttgcttt ttggcgtgat cgtgtttctg atcattgata caaggctggg 1465501 gtatgttcag tttgtgatgg gcgaaaaact gacttcgcta gcgaaagatt cctggagccg 1465561 gaacttgccg tttgagccgg agagaggcga gattctggat cggaatggtg tgaagctcgc 1465621 aacaaataaa agtgcgccga ccgtattcgt cgtgccgcgc caagttcaga atccgatgaa 1465681 aacgagcaag cagcttgcgg cggtgctcaa tatgtcagaa gaaaaagtat ataaacatgt 1465741 gacaaaaaaa gcgtcaatcg aaaagatcac tcctgaaggg agaaaaattt caaatgagaa 1465801 ggcgaaagaa atcaaagcgc ttgatttaaa aggtgtgtat gttgcggagg acagtatccg 1465861 tcattacccg ttcggcagct ttttatctca tgtgcttgga tttgcaggaa ttgacaacca 1465921 agggctcctt ggacttgaag cctattacga cgatgattta aaaggggaaa aaggttctgt 1465981 taagttttat acagatgcca aggggaagaa gatgcctgat gaagcggatg actatacgcc 1466041 gcctaaggat gggcttgata tgaagctgac agttgattca aaggttcaga cgataatgga 1466101 aagagagctt gataacgctg aggccaaata tcatccggac ggcatgattg ccgtagccat 1466161 gaatccgaaa aacggagaaa ttttggggat gtctagcagg cctgacttcg accctgctga 1466221 ttaccaatct gttgatccgt ccgtctacaa tcgaaatctg ccagtatgga gcacgtatga 1466281 accgggatct acctttaaaa ttattacact tgcagcagcc cttgaagagc aaaaagtaaa 1466341 tttgaaacgg gatcaatttt atgataaagg gcatgctgaa gtggacggag cgagactgcg 1466401 gtgctggaaa agaggcgggc acgggctgca gacgtatctg gaagttgtgc agaactcctg 1466461 caacccgggg tttgttgaat taggcgagcg cttaggaaag gaaaagcttt tcaaatatat 1466521 caaagacttt ggttttggac aaaaaacggg gattgatctc caaggcgagg gaacaggcat 1466581 cttattcccg cttgagagag tgggcccggt ggagcaagca actacggctt tcggacaggg 1466641 agtatccgtc acgccgattc agcaggttgc agcagtatcc gccgctgtaa acggaggaac 1466701 gctctataca ccttatattg caaaggaatg gatcgatcct gttacgaaga aaacggtcaa 1466761 aaaacaatca ccaatcgcaa agaaacaagt catttctgag gaaacatcca aacaaatccg 1466821 ctatgctcta gaaagcgtcg tcgcagaagg aaccggccgc aatgcatttg tagaaggata 1466881 tcgtgtcgga ggaaaaacgg gaactgcaca aaaggttaaa gatggaaaat atcttgaaaa 1466941 caaccatatt gtatcattta tcggtttcgc gccagcagat gatccgagtc tagtcgtcta 1467001 cgttgcggtg gataacccga aaggcacgat tcagtttggc ggaacggtgg cagcgcctat 1467061 tgtcggaaat attatgagag acagtctgcc ggaacttggt gtgaagcccc ggaaaaatca 1467121 aatcgagaaa aaataccaat ggaacgacac aaaaacaata gaagttccga atgttgtagg 1467181 gatgtctgtc tcagatcttg agtcactatt ggtgaatctc aatgtggatg cttccgggaa 1467241 agggagcaaa atcgttaaac aatcgccagc tgccggaacg aaagtaaaag aaggctcaaa 1467301 gatacgcgtg tatttgactg aagaagatga aaaggaggca gccgattgat tcgggctgcc 1467361 tattctttta ttgcagaaaa aatgctgata tctttcaaga ttagctggat gtatcctttt 1467421 atttacgcta aaatatgaac tgtatgctta aaatcattac cacatcattt gatgtgactt 1467481 caatgataaa aagaacgaat tagaatgttg agaggtttga tacgatgaaa cttacaaagc 1467541 tgcttacata cttaacaacc gaaccttctg taaacgactc acaagaccct gaaataactt 1467601 caattgagat ggactccagg gaagtaaaga aagggagtct ttttgtatgt gtaaaagggt 1467661 atacggtgga tggccacgat tttgcgcaaa aagcagtaga aaacggtgca gcggctattg 1467721 tggcagaaag agaggtcgat gtgaatgttc ctgttattat tgtccggcag tcacttcgcg 1467781 cgctcagcgt tttgtctgat gcgttttacg gacagccgac gaagaagctt cagctgattg 1467841 ggataacagg gacaaacggc aaaacatcaa cgacccacat ggtcgatgag attctgaaaa 1467901 aagcgggaaa acgcacaggc ttgatcggta caatgtacat gaaaatcgga gacgaaacac 1467961 ttcctgttaa aaacacgact ccggaaagcg tcacgctgca gaaaacgttt aagaaaatga 1468021 atgacaagca cgttgacact gcaatcatgg aggtttcttc ccacgctttg tctttaggac 1468081 gcgtccatgg ctgtgattat gatattgccg tgtttacgaa tttaacacag gaccatctgg 1468141 actatcataa aacgatggat gagtaccggc atgcaaaaag cttgctcttt tcccaacttg 1468201 gcggggcttt caaccatgaa catccaaagc gtgccgtcct gaatgctgac gatgaggcga 1468261 gcgcttattt tgaaaaggta acagctgcgc atatctctac atacggaatt aaaaacgatg 1468321 ctgatgtgat ggcgaagaac atcagtatca ctgcacaggg cacaagcttt gatctcgtga 1468381 caaacaaagg cacgaagcac atcacgatgt ctctcgtcgg acaatttaat gtgtataacg 1468441 tgctggccgc tgttgcgaca tgtattgcag caggcatacc gtttgaaatc atcactgagg 1468501 ctgttgaaga attgcatggt gtaagaggcc gttttgaatt ggtcaatcag cagcaggagt 1468561 ttcctgtcat tgtagactac gcgcacacac cggacagcct tgaaaatgtg ctggagacat 1468621 gcagagacat gacggaagga aagctatttg tcgttgtcgg ctgcggagga gacagagata 1468681 agacgaagcg cccgaaaatg gctaaaattg ctgtggagct ggctgacgag ccgattttca 1468741 cgtcagataa cccgagaagc gaagatcctc gcgcgatttt aagagatatg gaagccggag 1468801 tagagaacgc atactatcac agtattgcaa accgcgagca ggcgatcttt ttcgcaattg 1468861 ccaatgccaa aaaaggcgac gttgtcctca ttgccggaaa aggacatgaa acctatcagc 1468921 agatcggaaa tgaaactttc gattttgatg atgctgaagt agcggcgaga gccattgttg 1468981 aactcaataa gaataagacg aattcatagg aaagagatgt tactgaataa tggagcttga 1469041 aaagattttt catatggaaa aaaatcatga atatgataac tacgtatgtc gtttgaaaga 1469101 aacaggagga gaaaaggaca atgcttgagc aagtcattct gtttacaatt ttaatggggt 1469161 ttttaattag tgttctgctc tctccgattc ttattccgtt tttaagaaga ttaaaattcg 1469221 gccagagtat tagagaagaa ggaccgaaat cacatcagaa aaaatcaggg acaccgacaa 1469281 tgggcggggt catgatcata ctttctatca tagtgacaac aattgttatg acacagaagt 1469341 tttcagaaat aagccccgaa atggtgctgc ttctgtttgt tacgctaggc tacggtttgc 1469401 ttggcttttt agatgattac atcaaggttg tcatgaagcg caatcttgga ttgacatcaa 1469461 agcaaaagct gatcggacaa attattattg cggttgtatt ttacgccgtg tatcattact 1469521 acaattttgc gacggatatt cgcattcctg gaactgactt atcatttgat cttggctggg 1469581 cttactttat ccttgtgctc tttatgctag tcggcggatc aaacgcagtt aacctgactg 1469641 acggccttga cgggttatta tccggtactg cggcgattgc ctttggcgcc tttgccattc 1469701 tggcatggaa tcagtctcaa tatgacgtag cgattttctc agttgccgtt gtcggtgcag 1469761 ttctgggctt ccttgtattt aatgctcatc cggccaaagt ttttatggga gatacgggat 1469821 cgcttgcatt gggaggagcc atcgttacca ttgccatttt aacgaaatta gagatcctgc 1469881 tggttatcat cggcggtgta ttcgttatcg agacattatc cgttattttg caggtcatca 1469941 gctttaaaac gacaggtaaa cgaatcttta aaatgagtcc gcttcatcac cattatgagc 1470001 ttgtcggctg gtctgaatgg agagtagtcg tgacgttttg ggctgcggga cttttgcttg 1470061 ccgttttagg aatttacatc gaggtgtggt tataagtgga aaatgatcaa tttttacaga 1470121 aacagcattt tttaatcctt gggcttgcga aaagcggata tgcggcggcc tccattcttc 1470181 atgaaaaagg catttatgtt gcagtcaatg atcaaaagcc ttttgaagaa aatgaaccgg 1470241 cacaaaagct ttctgaaaaa ggaatcgaag ttgtttgcgg agagcatcca gtttctctgt 1470301 tcgatcagca tcaaatcacg attctgatca aaaacccggg aattccttat gaaaatatca 1470361 tggttcagga agcagagaaa cgaggtattc cggtttggac ggaaattgag ctcgcttact 1470421 acctgaccag cgccaagttt atcgggatta ccggatcgaa cggtaaaacg accacgacaa 1470481 cgctaattta cgaaatgctc aaggctgact cgcaaaaagc actgattgcc ggaaacatcg 1470541 gcacagtcgc aagtgaggtt gcctatcatg ctgatggaga tgaatggatc gttaccgaac 1470601 tgtcttcgtt tcagctgatg ggaacacacg ctttcagacc ggaaatcagc ctgattttaa 1470661 atgtatttga cgcccatctg gattatcacc atacgcgcga aaactatgaa aaagcgaaac 1470721 agaaagtgta ccttcatcag actgcttcag ataaagctat tgtcaaccag gatgatgaaa 1470781 ccgtcgtgcg tcttgctgaa gccggaaaag ccgaaatcgt cccattttca gtcagcaaaa 1470841 cgcttgaaca gggcgcatat gtaaaagaca gtatgattat gtttaacggc gaagccattc 1470901 ttcctctgga agaggttgta ctgcccggtg ctcataacct ggagaacatt ttagcagcta 1470961 ttgcagttgt gaaaacggca ggagcatcca atgaggcggt taaaaaggtg ctgacaagct 1471021 ttactggtgt gaagcaccgc ctccaatatg tcacaactgt gaatggccgc aaattttata 1471081 acgacagtaa agcaacaaac attctggcga caagcaaggc gctttcagct tttgataagc 1471141 cggtcattct gcttgcgggc ggactggatc gcggaaatgg ttttgatgac ttgaaacctt 1471201 atatgaagca tgtcaaagca gtgcttacat ttggccagac ggcgccaaaa ctcgagaaac 1471261 tcggcaatga actgggaata caacatgtca aacgtgtcga taatgttgaa caagcagtat 1471321 ctgcggcgtt tgcgctctca aatgaaggag atgtcatcct gctgtcaccc gcgtgtgcga 1471381 gctgggatca attcaaaaca tttgaagaac gcggtgacat gtttatagat gccgtgcata 1471441 tgcttaagta agggcttgtc ttgaagtaaa tcggcagccc taatgacttt aagcttgggg 1471501 tgtcgattgc tttgactact aaaaaaacat cgcctgattt gttattggtc atcattacgt 1471561 tattattatt aacaatcgga ttaattatgg tgtacagtgc gagtgcggta tgggcggatt 1471621 ataaatttga cgactcattc tttttcgcga aacggcagct tttgtttgcg ggaatcggcg 1471681 tcattgctat gttttttatc atgaatgttg attattggac ttggaggaca tggtccaaat 1471741 tgctgatggt tatctgcttt ttccttctgg tgcttgtttt gataccgggc gtcggaatgg 1471801 tgcggaacgg ttcaagaagc tggatcggag tcggagcatt cagcatacag ccttcagagt 1471861 ttatgaagct tgcgatgatt gcattccttg ctaaatttct ctctgaaaaa caaaaaaaca 1471921 tcacatcgtt cagacggggg ttcgtccctg cacttggcat cgtgttttca gcatttttga 1471981 ttatcatgtg ccagcctgac ctcggaacgg ggacagttat ggtcggaact tgtattgtca 1472041 tgatttttgt agccggcgca cggatcgccc atttcgtctt tctcgggctg atcggcctca 1472101 gcggatttgt cgggctcgta ctatcggctc catatcggat aaagcggatt acctcatact 1472161 taaatccatg ggaagacccg ctcggaagcg gatttcagat cattcaatcg ctttatgcag 1472221 tggggcccgg cgggttgttc ggaatggggc tcggacaaag cagacagaag ttcttttatc 1472281 tgcctgagcc gcaaacagac tttattttcg ccatcttgtc agaggagctg ggctttatcg 1472341 ggggaacact tattttgctc ctcttcagcg tcctgctgtg gagaggaatc agaattgcgc 1472401 ttggtgcgcc tgatctgtac ggaagctttg tcgcagtcgg cattatttca atgattgcca 1472461 ttcaagtcat gataaatatc ggcgtagtca cgggcctgat tcctgtaaca ggcatcacgc 1472521 tcccgtttct gagctacgga ggctcttcat tgactctaat gctgatggca gttggtgtgc 1472581 tgctgaatgt aagccgctac tcgaggtatt aacgaatgta tttccaagcc tcctgtctaa 1472641 catgaagctt ggaaacaatt gatgcgataa ccctgtccaa caaaacaggg ttatcgttat 1472701 gttatagaga aacttagact gggggaaaaa agaaatgcga attgcaataa gcggaggcgg 1472761 tacaggggga catatttatc ctgctcttgc ttttattaaa gaagtgcaaa gacgtcatcc 1472821 taatgtggaa tttttatata tcggaacaga aaacgggctg gagaaaaaaa ttgttgagcg 1472881 ggagaatata ccgtttcgtt caattgaaat tacaggattt aaaagaaaat tgtcatttga 1472941 aaatgtcaag actgtgatgc gttttctgaa gggcgtcaaa aagagtaaat cgtatttagc 1473001 ggaatttaag cccgatgccg taattggaac gggcggttat gtatgtgggc cggttgtcta 1473061 tgccgctgcg aaaatgggaa ttccgactat tgtccacgaa caaaacagcc tgccgggcat 1473121 cacgaataag tttctttcaa aatatgttaa taaagtagcg atttgttttg aagaagcgaa 1473181 atcacatttt cctagcgaga aagttgtatt tacgggaaac ccgagagcct ctgaagtcgt 1473241 ctcaataaag acgggacgat cattggctga atttgggctt tctgaagaca aaaaaacggt 1473301 cttaattttc ggcggaagcc gaggcgctgc accgattaac cgcgctgtca ttgacatgca 1473361 ggatgtgctg aaaacaagag actatcaagt gctgtatatc accggtgaag ttcactatga 1473421 aaaagtaatg aatgagctga aaagcaaggg tgccgctgat aatatggtca caaagccgtt 1473481 tcttcatcaa atgcctgagt atttaaaggc cattgatgtc attgtggcca gagccggtgc 1473541 gacaacgatt gccgaaatta ctgctctcgg aatcccaagt gttctgatcc caagtccata 1473601 tgtgacagcg aatcaccagg aggtcaatgc gaggtctctt ggccagcatg atgcggcgat 1473661 tgtactgaaa gaaacagagc tcagcgggga gaagctgatt gaagcgctag accggattgt 1473721 actgaatgag caaacgttaa aggaaatgag cgaacgaaca aagtcactcg gtgttcctga 1473781 cgcggctgcc cgtttataca gcgtactcga ggaattaaaa aaatagtaga aaagcaaatg 1473841 gaatgcggag gtttacgatg gagaaagtga tacaggaatt aaaagaacga gaagtcggca 1473901 aggttcttgc aaatgaaccg ctcgcgaatc atacaacgat gaaaatcggc ggacctgcgg 1473961 atgtattggt cattccaagc agtgtggatg ctgttaaaga catcatggac gtgattaaaa 1474021 aatatgatgt gaagtggaca gtcatcggcc gcggatcaaa tcttcttgtt ttagatgaag 1474081 gaattagagg cgtagtgatc aagctggggg cgggtcttga ccatttggag cttgaagggg 1474141 aacaagtaac agtcggaggc ggttattcgg tggtccgcct tgctacatca ttgagcaaaa 1474201 aaggcctgtc cggtttggaa tttgctgccg gcattccagg atcagtcggc ggagcggttt 1474261 atatgaatgc cggcgctcac ggttctgata tgagcgagat cctcgtcaaa gcgcatattt 1474321 tatttgaaga cggaacgatt gagtggctga caaatgagca gatggatttc agctacagga 1474381 catctgtact gcaaaagaaa cgcccgggcg tttgccttga agctgttttg cagcttgagc 1474441 agaaggataa ggaatcaatc gttcagcaaa tgcaaagcaa taaagactat agaaaaaata 1474501 cacagccgta ttcaagccct tgtgcgggaa gcatattcag aaatccgctt ccgaatcatg 1474561 ccgggaacct tgtagaaaaa gcaggcttga aaggatatca aatcggcggt gcaaagatat 1474621 cggagatgca cggaaacttc atcgtcaatg cggggggagc atcagcaaaa gatgtgcttg 1474681 atctcattga ccatgtgaaa aagacaatcc gtgaaaaata cgagattgat atgcacacag 1474741 aggttgaaat catcggcgga aatcgctgat tcaagttctg actgaagctg ttcatatgat 1474801 atactgtaag caaacgacaa acggcatcat agtatgccgt ttgttttgga atagacagac 1474861 ttttaacagc tgtttcattt gaatgaggtg aacaggcaat gaacccgggt caagaccgag 1474921 aaaaaatcgt taacattgaa gagcggatcc ctaaaattaa agagcagagg aaacaaaagg 1474981 caaaccgccg tctcatttca tttattatgc tcttttttat tatggtgctg atcattgtgt 1475041 acctgcaaac accaatcagt aaagtatcaa caatctctgt tacagggaat gaaaatgtat 1475101 caaaaaagga aattatcgac ctttccgata ttaacagcgg agatactgag ttttggagtt 1475161 tggacaagca aaaaacagaa aagaagattc agcaaaataa attagtgaaa aaagcggaga 1475221 tcagcaaatc gcttcctaat aaaatcaaca ttgcaatcga agaatataaa gcgattgctt 1475281 atttagaaaa agacgatgtg tactatgaag tgcttgaaaa cggctcagtt ctgccaaacg 1475341 aagtaacgcc ggatgatgcc ggaccgattt tagtgaattg gacaaacgcg aagaagcggt 1475401 ctcaaatggc caagcagctc gatgcgttgt caaattcgtt aaaacagtcg atttcagaaa 1475461 tttattatac gcctgtaaaa atggatgaaa accgtattaa gttgtacatg aacgacggtt 1475521 atgttgttac ggcatctatt aaaacgtttg cagaccgaat gaagacgtat ccttctatca 1475581 tctcacagct aagcagcaat aaaaaaggaa tcattcattt agaagttgcc acctattttg 1475641 aagagtttgg gaaaaacgat aaagctgcta aaaaggaaga tgaaaattga ggggcaaatc 1475701 agcagtcctt ctttccttga ttatgcttat cgcaggtttt ttgatttcat tttcttttca 1475761 aatgacaaaa gaaaacaaca aaagcgcggc tgagacggaa gagtggaaaa aagaatatgc 1475821 gctgagagat gaactgctga aacaagagaa agaaaataag aagtttgaaa aagaattata 1475881 tcaaaagcaa aacaaagtcc gccaggcgga aaataagctg aagaaagaga agtcggaata 1475941 ctataatgtc ctcgaagata cagaaaaata caggatgtat attggggaag tcggtgtgca 1476001 gggagaaggc gttgaggtga cattggaaga tgcgtcatac ataccggaag gggagaatgt 1476061 gaatagttac atcgttcacg aaagccatat cttccaagta gtaaacgaac tgtatatctc 1476121 aggagcggca gctgtcgccg ttaatggaca gcgtttgacg catgattcgt atatcaaatg 1476181 caatggtcct gtggtaacgg tagacggggt gcagcatccc gctccgttta cggtatccgc 1476241 tattggagat ccagatgtcc tgctgccctc gttaaatatc gctggaggcc taattgatca 1476301 gctgtcaatg gatcatattt ctgtgtcggc agaaaaagag aaaaacgtac aaatgaaacc 1476361 gattctgaaa acgaaggaat gactgaaaaa gcgggtgaaa tagattgaaa ataaagcgtt 1476421 ccttcataag catcagtgtt cttatggtca tcttcggcct gatgatatct gttcagttta 1476481 attcgttaaa gcaccccaaa gtccgggata caagagatat gtgggatatt agggaagagc 1476541 tgacatcaga gcagaagaag caggaaaagc tgctggctga aataaacaaa tatgacaaat 1476601 tgctgaatag ctattcgcaa acgaaagaaa tgacaaaaga aaccgcgcta aataatacct 1476661 tgcaatcctt aaaaaaaaca gccggcatga ccgatataac aggtagcgga attgtcatta 1476721 cgatttcccc gcttttttct gaaagcttaa caggagagcc gatcgaaaat ccgcctccgg 1476781 atttgctgaa aaagctgata aatgaactca actcctacgg tgcagagcat atctcgatta 1476841 atgagcgaag agttgtgaat catacagtca tcagagatat aaacggcact acaaaaatag 1476901 acggatacgc ccttgacgat tatcctttaa cagtaaaagt gcttgccaaa gatccggaca 1476961 tgttacacag cagagtgaag gggtcaggcc ttgaggatct ttttgcatct gaaaatttag 1477021 cattaaaagc cggtaaatct gaaagcaaac taacattaaa agcatatgac agaccactgg 1477081 acgtacaaca gctgaaactg cttaaagact gaaaaggagg agaattgtca tgtggctgcc 1477141 cgtgttggga ctggtgctcg gaatagcgat tggactaatg acaaacttaa cgataccgag 1477201 tgaatactca aactatttat cgcttgcggt gcttgccgca cttgatacat taatcggcgg 1477261 aatcagggcg catttacaag gtacatatga tgaaatggta tttgtttccg gtttcttttt 1477321 taatattata ttggcaataa gtttagcttt tctgggagtc catcttggtg tagacttgta 1477381 tttagcaggt atattcgcat ttggagtcag attatttcag aatatagccg ttatcagaag 1477441 aaatctacta acaaagtgga ctctttctaa aaaaaataaa aaaaatgtga tataaaagag 1477501 gatatacata ggatataacg aatattttca ataaacataa aatgtgaaaa gcacataaaa 1477561 atattctgtt gttatttttt gttacacact tgtaaagcca cattcattgt attgttgttc 1477621 cgcaaataat agaatagaaa tgatcgaaat gtgaggaggt gccatagaat gaacaacaat 1477681 gaactttacg tcagtcttga catcggtacg tccaatacaa aagtgatcgt cggagaaatg 1477741 acagatgatt cccttaatat tatcggtgtg ggaaatgtac cgtctgaagg gttgaaaaaa 1477801 ggctcaatcg ttgatataga tgagaccgtt cattctataa gaaaagcgtt tgaccaagct 1477861 gaaagaatgg taggttttcc gcttagaaaa gctattgtcg gcgttaatgg aaattatatc 1477921 aatattcaag atacaaacgg tgttgtagca gtttccagtg aaaataaaga aattcaggtt 1477981 gaagatgtac gccgtgtcat ggaggcggca caggttgttt ccgtaccgca tgaacagctg 1478041 attgttgacg tcattcctaa acagtttatc gtagatggaa gagatgaaat caccgacccg 1478101 aaaaaaatgc tgggtgtgcg tttagaagta gagggcacct tgatcaccgg ttcaaaaaca 1478161 atcttacata acttactccg ctgcgttgaa agagctggta ttgaaataac tgatatttgc 1478221 cttcagccgc tggcagccgg ttctgctgca ttatcaaagg acgagaaaaa ccttggtgtg 1478281 gctctcattg atataggggg agggtcaaca accattgccg tattccagaa cggacatctc 1478341 acttctaccc gtgtcattcc tctcggaggc gaaaatatca ccaaagatat ctccatcgga 1478401 ttgagaacgt caacagaaga agcagaacgc gtgaaaaagc aacttggaca tgcctactat 1478461 gacgaagcct cggaagatga aatatttgag gtaaccgtta taggcaccaa tcaaaaacaa 1478521 acatttacac agcaagaagc agcgaatatc attgaagcga gagtagagga aattcttgaa 1478581 attgtttcag aagagcttcg cagtatggga attaccgatc tgccgggagg cttcgtgctg 1478641 acaggaggac aagcagctat gccgggtgtc atgtctttgg cacaggatgt gctgcaaaac 1478701 aatgtcagag tggcaagccc gaattatatc ggtgtaagag atcctcaata tatgacggga 1478761 gtgggcctga tccaattcgc ctgccggaat gcaagaatcc aaggcagaaa aataggcttt 1478821 aagatgcctg aagaagcgat acaggaaatc gcagtctcat catctgagga acaagagcag 1478881 catcatcacc aaaatgaggt gcagcagcgg ccaaaaggaa aacaaaaaac acaagccgaa 1478941 cataataaac agagcaaaat gaaaaaacta ttaagcatgt tttgggaata gatagatagt 1479001 cattcggcag attaggagga tttagcatgt tggagttcga aacaaacata gacggcttag 1479061 catcaattaa agtaatcgga gtaggaggcg gcggtaacaa cgccgttaac cgaatgattg 1479121 aaaatgaagt gcaaggagta gagtatatcg cggtaaacac ggacgctcaa gctcttaacc 1479181 tgtcaaaagc agaagtgaaa atgcaaatcg gcgcaaagct gactagagga ttgggagcag 1479241 gtgcgaatcc ggaagtcggg aaaaaagccg ctgaagaaag caaagagcag attgaagaag 1479301 cacttaaagg tgctgacatg gtattcgtga cagctggtat gggcggcgga acaggaacag 1479361 gtgccgcacc ggttatcgca caaatcgcga aagacttagg cgcattaaca gtcggcgttg 1479421 tgacaagacc gtttaccttc gaaggacgca aaagacagct tcaggctgca ggcggaatct 1479481 cggcaatgaa agaagcggtg gatacactga tcgtgatccc gaacgaccgt atccttgaaa 1479541 ttgttgataa aaacacaccg atgcttgaag cattccgcga agcggataac gtacttcgcc 1479601 aaggggttca aggtatttct gacttgattg ctacacctgg tcttatcaac cttgactttg 1479661 ctgatgtgaa aacaatcatg tcaaacaaag gatctgcttt gatgggtatc ggtattgcta 1479721 ctggggaaaa tcgcgcggca gaggcagcaa aaaaagcaat ttccagcccg cttcttgaag 1479781 cggccattga cggtgcgcaa ggcgtcctca tgaacatcac tggaggaaca aacctcagcc 1479841 tatatgaggt tcaggaagca gcagacattg tcgcttcggc gtctgatcaa gacgtaaaca 1479901 tgattttcgg ttctgttatt aatgaaaatc taaaagatga gattgtggtg acagtgattg 1479961 caaccggctt tatcgaacaa gagaaggacg tgacgaagcc tcagcgtcca agcttaaatc 1480021 aaagcatcaa aacacacaat caaagtgttc cgaagcgtga gccaaaacgt gaggaacctc 1480081 agcagcagaa cacagtaagc cgtcatactt cacagccggc tgatgatacg cttgacatcc 1480141 cgacattctt aagaaaccgt aataaacgcg gctaatgtaa aggacaaaat cgttttcgat 1480201 tttgtccttt tttgtttttc tcttcacact ttccttctta taaagtcttt ttccctattg 1480261 cttccttcgc gagctcgatt atggatggtt tacgttttgg aaaaagtaag gtatcctagt 1480321 tcgtacaaag ttttatgaaa attaaaacaa ttataaaagg caataaagag gaggaccacg 1480381 atgattttgc agcttgacaa tgtctcacta aaacggaatg ggaaatggat actgaaagat 1480441 attcattgga aggtggaaga aaaggaaaat tgggtgcttt acggcctaaa tggcgccggg 1480501 aagacagcgc tgttaaatat gctttgctca tattattttc caacatcagg cgagatgcag 1480561 gtgctcggcc atgaatttgg caaaacagag cttggggaaa agctcagacg taaaattggc 1480621 ctcgtctcag cagctcttca gcaaaaattg tatccggcag attcagcttt tgaaattgct 1480681 ttgagcggag cttacgcttc gattgggtta tatgaaacgc caagtaagga aaccagggaa 1480741 aaagcgatag gtttgttaga ggacttggga gcaattgaat atgccgatcg ccgctatgaa 1480801 accctttctc aaggggaaaa acaaagagca ttgattgcta gagcactaat ggccgatccg 1480861 gagctgctga tactggatga accagtcaca ggactggatt ttattgcccg ggaaaagctg 1480921 ttagatacga ttacatacat tgcaaacaaa gaaaatgcac catctatcct ttatgtgact 1480981 catcatgctg aagaaatttt gcctgtcttt gataaagccc ttttattaaa acagggagag 1481041 gtttttggat ccggagaaat aaaggaaatg cttactgatc aaatactttc cgcttttttt 1481101 gatacgccaa tccatgtatt atggaatcag gatcggccgt ttttaacaag agctgagccg 1481161 ataacgaatg cctgacaaat atatatagat tcatcctagg ggtgctttgc gaagctgaga 1481221 gagactttgt ctcaaccctt ttgacctgat ctggatcatg ccagcggagg gaagcggtga 1481281 aaagcggagt acatcggact ccgtttgttt ttattaagcc gtttcatcac atttgaaacg 1481341 gcttttttga ttttaaagaa taggagcgga tttacattgg atcaacaaat atactctttg 1481401 caaaaaaaag tggaagaaca taaggaggag cttattcagc ttgcgaaaac gctgatttct 1481461 tatcaaacac ctgctccgcc tgcaagaaat acagagggca ttcagtcttg gattgcggga 1481521 tatttaaatg aattgggatt ctcgatcgac aaatgggatg tgtaccctgg agatcccaat 1481581 gttgtaggga agctaaaagg aacagattca gcagattatt atagcctgat tatcaatggc 1481641 catgtagatg tggcagaggt aaaagaggat gaagaatgga agcacgatcc gtttcatccc 1481701 attgaaaaaa acggtctctt aatcgggcga ggcgcttccg atatgaaggg cggaatggct 1481761 tgtgtgctgt ttgctgtcaa attaattcgt gaagcaagca ttgaacttcc aggtgatctg 1481821 attctgcaat cggttattgg ggaggaagtt ggagaggccg gcacacttga atgctgcaag 1481881 aggggctacc acgctgattt tgcaattgtc gcggatacga gcgatatgca tattcaaggc 1481941 caaggcggtg tcattacagg ctggatcgaa atcaaaagca gtcaaacatt tcatgatgga 1482001 acgagacgga atatgattca tgcaggcgga ggaacattcg gagcaagcgc aattgaaaaa 1482061 atggcaaaaa tcattgcggg gctcggtgaa cttgagcgcc actggtctat tatgaaaagt 1482121 tatcccggtt ttaaaccagg cacaaatacg attaacccgg cagttataga aggcggcaga 1482181 catgcggctt ttatagcgga cgaatgccgg ctgtggatca cagtccattt ttatccgaat 1482241 gaaacccatg accaagtggc agcggaaata gaagattacg tcaatcggct gagtgacagt 1482301 gatatttggc ttagggaaaa ccgccctgta ttcaagtggg gaggctcatc tatgatagaa 1482361 gacaggggag aaatttttcc ggcattggaa gttgaccctg gccacccagg cgtcttagcg 1482421 ctaactgcct ctcatcagaa agtgaaacgg gagtgtccaa ttattgacgt ttctcaatca 1482481 gttacagatg gcggatggct gtatgatgcc ggtattccat gcgtaatata cggtcctgga 1482541 gatctgcaca atgcacactc tgtgaacgag aaggtatcga ttgagcagct agtagagtat 1482601 acaaaaatta tactcgattt tatcatcagc tggtgcagcc ggaaaaaaga acaatgacat 1482661 gaaaatttct tcttgctgac aaggttcagc ctgcccgttc atatacttga acaaaaggac 1482721 ggaaaaagga cgtgatggaa tgatcagcat ttcagaattt caggtaaagg atgtcgtcaa 1482781 tgtctcaaac ggaaaaaagc tggggagtat tggtgatatt gatatcaatg tgaccactgg 1482841 aaaaattcag gcgatcatac tcggaggaaa tgggaaagtt ctcggatttt ttggaaaaga 1482901 agaggaattg gtcattccat ggcgaaatat agtaaaaatc ggggaagatg taatcttagt 1482961 ccgattaagt gaaccacatg cataaacctg cttgtctgcc gcagattggc aaatgccgga 1483021 agtctcgatt cttccggcac atttcattta gaaatatgca aatcggcgct caacgaatgc 1483081 agtaagatgt ggtaaaataa gtgggaaatt ccgctttttt aaatgtttgt cgaaaggttg 1483141 gatcatcatg aatacatatc acccattcag tcttaccaca ccctcgacac tcatgataca 1483201 agactgggct caaacgaatc aaaacaacaa agaggtcatt gccggattta cgacaaaaaa 1483261 cggcggtgtc agccaaaagc cttttgaatc gttaaataca ggattgcacg ttcatgacaa 1483321 agatgcagat gtagttaaaa atcgtgaata tattgccgat atgtttaata ctgatttgca 1483381 gtcttgggta ttcgctgatc agacacatga taatcgcgtt cagaaagtga cgcagaggga 1483441 taggggaaaa ggcgcccgtg agtatcacac ggctctaaaa gcaacggacg ggatctatac 1483501 aaatgaaaaa aatgtatttt tagcattatg ctttgctgat tgtgtgcctc ttttctttta 1483561 tgatccggtt aagtcgcttg tcggagtcgc ccatgccggg tggaaaggca ccgtcaaaca 1483621 gattggcaga gaaatggtga agcaatggac tgagaaggaa ggttcaaatc cctcagatat 1483681 ttacgctgtt attggcccgt ctatcagcgg agcatgctat acggtagacg accgcgtcat 1483741 ggatgctgtc cgcgcattgc cggtttcagc agaccttgcc gccaatcaga cggcaaaggc 1483801 acaatatcag cttgatctga aagagctgaa ccgtcttata ctgatggaca gcggtttggc 1483861 aagtgaacaa atttctgtca gcggtttatg cacggaaagc gagccgtctc ttttctattc 1483921 tcatcgccgc gatcagggga aaactggacg gatgatgtcc tttatcggaa tgaaggaggc 1483981 ataaaagatc ttgcgtgttg ttgataattt acgacatata aacgaacgaa taaacgaagc 1484041 atgtaacaga tcgggccgca gctccgatga agttacggtt attgcagtca caaaatatgt 1484101 atcacctgaa agagcacagg aggcagtaga tgctggcatc acctgcctcg gagagaatcg 1484161 ggatgcggaa ctgctccgca aacaggaatt gatgaaaggg aatccggaat ggcattttat 1484221 cggcagtctg caatcaagaa aagcaaaatc tgtcgtcaat tcggtttcct atatccattc 1484281 cctagaccgg ctctcattag cgaaagaaat tgaaaaacgg gctgaaggta ctgtacgatg 1484341 ctttgtgcag gtcaatacct ctcttgagcc ttctaaacat ggcatgaaaa aagaagaagt 1484401 cattccattc atacaggagc tttccggttt cgaacatatc cttgttgccg ggctgatgac 1484461 aatggctccg ctgactgatg atcaagatca gatcagaagc tgtttcaggt cgctgagaga 1484521 actccgtgac caggttcaga agctgaacca gccgaacgct ccgtgtactg aactgtcgat 1484581 gggcatgtca aatgattttg aaattgcaat tgaagaagga gctacttata ttagaatcgg 1484641 ctcatcgtta gtcggaaatg aaacaggggg tgtacagcaa tgagtatgaa aaataaactg 1484701 aaaaactttt tctcaatgga agatgaagaa tacgaatatg aatatattga gacagagcgg 1484761 gaatctcatg aggagcatga gcaaaaagaa aagccggctt acaacgggaa taaacctgcg 1484821 ggcaaacaga atgtagtgag cttgcaaagt gttcagaaat cctctaaagt ggtgttgagt 1484881 gagccgcgcg tttatgcgga ggcgcaggaa atagccgacc atttgaagaa ccggcgggca 1484941 gttgtcgtca atcttcagcg gatacagcat gaccaggcga agcggattgt tgacttttta 1485001 agcggaaccg tttatgccat tggcggcgat attcaaagaa tcggctcaga tattttcctc 1485061 tgcacgcctg acaacgtaga tgtatcaggc acaatttctg agctcatatc tgaagacgaa 1485121 catcagaggt ggtaaagcga gatgatcctt tatcaagttt tttcggtttt aagcttatta 1485181 atcacaatat actcatttgc cctgatcata tatattttta tgtcatgggt gccgagtacg 1485241 agggaaacag cagtcgggcg ttttttggct tcgatttgtg aaccatatct cgaaccattc 1485301 agaaaaatca tccctccgat tgcaatgctg gatatttcac caatcgtagc aatacttgtg 1485361 cttcggtttg cgacaaccgg cttgtgggga ctttatcgca tgattgcgtt ttaatgtgac 1485421 agtttgatag gggcttggca gcagccaagc ctctttacat agaagggaaa gacgatgagc 1485481 gatatatatc agcacttcag aaaagacgag cgggccttta ttgatcaagc gctcgaatgg 1485541 aaaagaattg tccaggagca gtaccggatg aagctgaccg actttttaga tccccgagag 1485601 caggtcatcc tctctgctgt tacgggacag gcagatgtcg ggcttgcctt ttccggcggc 1485661 tatgacagag cggagcggaa acgggcgatt ctgtttccag agtacattac tccggaagaa 1485721 tcagattttg aactgcaggc gtttaacgtc cgttatgctg acaagtttgt ctcagtagat 1485781 catcgttctc tgcttggtgc attaatgggc ataggattaa agcggcaaaa attcggtgac 1485841 atcgtgtttt ctgagacagc agtgcaattg attgtctcag ccgataccgc tgattttgtg 1485901 gctgcacagc tgacccaagc aggcaaagcg gcggtcagcc tagagaaaat cgacttgtca 1485961 gaccttaaca ttccagcagt tgatgtcgaa ataagagatg acacggtttc ttctttaagg 1486021 cttgacgccg tctgcgcctc tatgagcagg caatcccgcc agaaatcaca gacgcttgtg 1486081 aaaaacggcc ttgtgaaagt gaactggaag gtggttgaag atccttcata catagtcgcg 1486141 gaaggggaca tgctgtctat cagaggtttt ggccggtgca gcttaacaaa aatcgaagga 1486201 aaaaccaaaa aagacaaatg gagagttacg tttgaacgac aaaaatagtc ggtttttcag 1486261 tttttttctc catctgtgcg aaatttgttt tataatgtga actagataac cgtactgaaa 1486321 tgtaaaaatg gaggtggcat catgccatta acgccaaatg atattcacaa caagacgttt 1486381 acaaaaagtt ttcgcggata tgatgaagat gaagtaaatg aattcctagc ccaagtcaga 1486441 aaagattacg aaattgttct ccgcaagaaa actgagcttg aagcgaaagt caatgagctt 1486501 gatgaaagaa tcggacactt tgccaatatt gaggagacat tgaataaatc aattttagtt 1486561 gctcaagaag cggctgaaga cgtaaaacgc aattctcaaa aagaagcaaa gctgatcgtt 1486621 cgggaagcgg agaaaaacgc tgatcgcatt atcaacgaat cgttatcaaa atcaagaaaa 1486681 attgcaatgg aaattgaaga gctgaaaaaa cagtctaaag tgttcagaac acgtttccaa 1486741 atgctgattg aagctcagct tgatcttctg aaaaatgacg attgggatca tctccttgag 1486801 tatgaagtcg acgctgtatt tgaggaaaag gaataaattc tctgattatc ttgacatttt 1486861 cttagcttgt cgaatataat acgttcataa attcagatga aaaaacggtt gaaagggaca 1486921 gtcatgtttc cttcaggcct tcatagcgac ccggagatgg tgagagtccg ggatggccgg 1486981 aatcatgtag atcagccctt tagtttcctt gctgaactca cagtaggtta ggacgttcat 1487041 cacgttacga tgctcaagag gaaaaagtgt atgcttgctt tttctaaaag ggtggtaccg 1487101 cgagataagc tttctcgtcc cttatgggat gagagggctt tttttatttt ctgaaaaaat 1487161 gcagtggagg aatgaaaatg gattttaaag acacgctctt aatgccgaaa acagatttcc 1487221 cgatgcgtgg aaatttgcca aaccgtgagc ctgacattca aaaaaaatgg gaggaagaag 1487281 atatctaccg tcttgttcag gaacggacga aagaccgccc gaaatttgtt ttacatgacg 1487341 gacctccgta tgcaaacggc gacatccata tgggccatgc acttaacaag attttgaaag 1487401 acttcattgt ccgctataaa tcaatgagcg gctacaacgc accgtatgtg ccgggctggg 1487461 atacacacgg attgccaatt gaaacagctc tgacaaaaaa caaaaaggtc aaccgcaaag 1487521 aaatgtcagt agcggaattc cgcaaactat gcgaagagta cgcttggaag caaatcgagg 1487581 gacagcgtga gcaattcaaa cgtcttggtg tccgcggtga ctgggaaaac ccatatgtga 1487641 cattaaaacc ggaatacgaa gcgcagcaaa tccgcgtatt tggtgaaatg gcaaaacgag 1487701 gctacattta caaaggcctt aaaccggtta actggtcacc ttcaagtgag tctgctctgg 1487761 ctgaagccga gatcgaatat caagataaac gttcagcatc tatttacgtc gcttttggtg 1487821 taaaagacgg aaaaggcgtt cttgaaaacg gcgagcgcat catcatttgg acaacaacgc 1487881 cgtggacaat tccggcgaac ctcggaatct cagtgcaccc tgatcttgag tacagcgtga 1487941 ttgcagtagg tgaagaccgc tttgttgtag caagtgcctt agtcgaaaat gttgcatcgg 1488001 catgcggatt tgatcagtat gaagtgacaa gaacggtcaa agggaaagac cttgagaaca 1488061 ttatcgctga acacccgcta tatggcagag actctctcgt tatgcttggt gaacacgtaa 1488121 caactgatgc cggaacaggc tgtgttcata cagcgcctgg acatggggaa gatgacttta 1488181 tcatcggcca aaaatacggt ttagatgtgc tttgcccggt cgatgaaaaa ggtgtaatga 1488241 caagcgaagc tcctggcttt gaaggcatgt tctatgatga tgcaaacaaa gcgatcacac 1488301 agcagcttga tgaaaaaggc gcacttgtga agcttgaatt cattactcat tcttatccgc 1488361 atgattggag aacaaaaaaa ccaaccattt tcagagcaac agcgcaatgg tttgcgtcta 1488421 ttaaagattt cagatcagac ctgctggatg ccattaaaga aaccaaatgg gttcctgaat 1488481 ggggcgagca gcgtttgcac aacatggttc gggaccgcgg agactggtgt atttccagac 1488541 agcgtgcgtg gggtgtgccg attccggtat tttacgctga aaacggagaa ccggttatta 1488601 cagatgaaac cattgaacat gtttctgaat tgttcagaca gcatggatca aacatttggt 1488661 ttgaaaaaga agcaaaggat cttcttccgg aaggctttac gcatcctggc agcccgaacg 1488721 gcacatttac aaaagaacag gatatcatgg atgtttggtt tgattcaggc tcttcacatc 1488781 aagcagtgct tgaagaacgt gatgacctcg ttcgcccggc tgatctatac ctagagggat 1488841 ctgaccaata tcgcggctgg tttaactctt ctctttctac agcagtagcc gtaacaggga 1488901 aagcgccgta taaaggtgtg ctcagccatg ggttcgcact ggatggagaa ggacgtaaga 1488961 tgagtaaatc aatcggtaac gttgttgttc cggctaaagt catgaaacag cttggtgccg 1489021 acatcttaag attatgggta tcttcagtgg attatcaggc ggacgttcgc gtgtctgacg 1489081 ccattctgaa gcaggttgcg gaagtatatc gtaaaatccg caacacgttc cgtttccttc 1489141 acggcaacct tttcgatttt gatccaaaaa caaatgcggt ggctgtcgaa gatcttcgcg 1489201 aagtggatca gtatatgctg attaagctga acaagctgat tgataaagtg aaaaaagcgt 1489261 atgatgagta cgaatttgcg gttgtgtatc acagcattca taatttctgc acaatcgaat 1489321 tgagctcatt ctaccttgat tttgcaaaag atattgtcta catcgagcat gcggatcatc 1489381 cggatagacg cagcatgcag acagtattct acgaaacgct tcttgcatta gtgaagcttt 1489441 cagcgcctat ccttccacat acggcagacg aattgtggtc tcatttaaca tttgttgaag 1489501 agcagagcgt tcagttgacc gatatgccgg aaacaatcac ggttccaaac agtgaagcga 1489561 ctgaagaaaa atttgaccgc tttatggctc ttcgtgatga cgtgttaaaa gcattagaaa 1489621 ctgcgcgaaa tgaaaaaatt atcggtaaat ctttggaagc aaacctgaaa ttgtatccaa 1489681 acaaagaaaa caaggagctc ttggcttcca taaaagaaaa cctttctcag ctgtttattg 1489741 tgtctgaact gacaatcagc gaagaaaatg aagcgccgaa cgatgcgcaa agctttgcga 1489801 cgggtaaaat cgctgtcgag aaagcggaag gcgaaatgtg tgagagatct cgtgtgattt 1489861 caaaagatgt aggggcaaat ccgaaatatc ctacactttc attacgcaac gctgaaatcg 1489921 ttgaaaaata ctatcaaaaa taatgcaaaa gagcccggcg taaaagccgg gctttttttg 1489981 tgccaagagt gacatccttt agaacgaaag gaaaaatctt atgggcttta gatcatcatt 1490041 cacaggcaac aataaagata ctacgttaag agcaggagtt gtgaagaatg aatgatcaac 1490101 tgaccgcaat ttatacggaa cttcttctga tgaaagaaga attacagtcg agattatttg 1490161 agtattcttg ctttcaggtt tctacaagcc cgcaagcagc aatcaatcaa aaacaaaaag 1490221 caactctgat ctatcatatt aaagaagaac ttcaagacgt tctccttgca ttgtccaaaa 1490281 tcgaaaacgg cacattcgga tactgtgaag aaactggggc ccccattcct cttgcaaagc 1490341 tggcagtgct gccgacggcc cgaacagcaa acgattttct ttattctgtc caatttgaga 1490401 aaaaaacgct tccgatatgg aaatcaacgg atatcgaata tggtcaggca ctgtatgaat 1490461 aacagtgtct gtccggttaa tatgcctgat atttctttac tccagtgctt tttattgata 1490521 aaatgcataa tggattaaag taaccgtaaa ctggaggaac gtttgtgctg tattatatga 1490581 ttgcactact tattattgca gccgatcaat tgacaaaatg gctagttgtt aagaacatgg 1490641 aacttggcca aagcattccg atcattgatc aggtattcta tatcacctcc catcgcaata 1490701 cgggtgctgc atgggggata ttagcgggtc aaatgtggtt tttctacctc ataacaaccg 1490761 ctgttattat tggtattgtt tattacatac agcgttatac aaagggacaa aggcttcttg 1490821 gcgttgccct cggacttatg cttggcggtg ccatcggcaa ctttatcgat cgggctgtca 1490881 gacaggaagt tgtggatttt atccatgtta ttattgtcaa ttacaattac ccgatattta 1490941 acatcgcgga ctcttcacta tgtgtcggcg taatgctttt atttatacaa atgctgttgg 1491001 acagcgggaa aaagaaaaag gagcaatagc atgaatcaaa ttgatataac cgcttcagaa 1491061 gaacaaaaaa gtgagcggat tgataaattt ttggcatcga ctgagaatga ttggtcaaga 1491121 acccaggttc agcaatgggt aaaagacgga caggttgtcg tgaacggaag cgcggtgaaa 1491181 gcgaattata aaattcagcc gggtgatcag gtgaccgtca ctgtacctga accggaagcg 1491241 ctcgacgtcc tggcagagcc tatggatctg gatatttatt atgaggacca ggatgtgctg 1491301 gtcgtcaaca aacctcgcgg aatggttgtt cacccagcac ccgggcatct tacgggcaca 1491361 cttgtaaacg gtcttatggc tcattgcaca gacctttccg gaataaatgg tgtgatgcgc 1491421 ccgggtattg ttcacagaat cgataaggac acgtccggtt tattaatggt ggcgaaaaat 1491481 gatatggcgc acgagtcact cgtaaaccaa ttggtcaaca aaacggtcac gcggaaatat 1491541 acggcggttg tccacgggct tatttctcat gatgacggca caattgacgc gccgatcgga 1491601 cgggataaaa aagaccgtca aagcatgact gtgacacgtg atggcaaaaa cgctgtcact 1491661 cattttcatg tgcttgagcg ttttcaggat tttacgttag tggagtgcca gcttgaaaca 1491721 gggagaaccc atcaaattcg tgttcatatg aaatatatcg gattcccatt agcaggcgat 1491781 ccgaaatacg gcccaagaaa aacaatcgac tttaatggcc aagcgcttca cgcgggagtt 1491841 ttaggttttg accatccacg aacaggagaa tatgtcgaat ttgaagcgcc gcttcccgag 1491901 gatatggcag aattaatcga aaacctcaga aaaaacggtt gacagagggt ttcttttctg 1491961 aaataataaa cgaagctgaa tagattcttt aaaacagtcc agagaggctg agaaggataa 1492021 cggatagacg ggatgcgtgt ataggcgcgc accttgtcct aaaacccctc tatgctctgg 1492081 caggaggggt tttttcttct atatgaactg tgaggtgtca cacattgaat caaaaagctg 1492141 tcattctcga cgaacaggca attagacggg cgctgaccag gattgctcac gaaatgatcg 1492201 aacgcaataa aggaatgaat aactgcattc ttgtcggcat taagacaaga gggatttacc 1492261 tggcaaaacg ccttgcggaa cgcattgaac agattgaggg aaatcctgtt acagtcggtg 1492321 aaattgatat tactctttac agagatgatc tttctaaaaa aacaagcaac gatgaaccgc 1492381 ttgtaaaagg tgcagatatt ccggtagata ttacagatca aaaagtcatt ctcgttgatg 1492441 atgttctgta taccggaaga acagtcagag caggaatgga tgcgcttgtt gatgtaggca 1492501 gaccttcctc cattcagctt gcagtgcttg tggacagagg acaccgggag ctgccgatcc 1492561 gagcggatta tatcgggaaa aacatcccga catcaaagtc tgaaaaggtt atggtacagc 1492621 ttgatgaggt agaccaaaac gatctcgtcg ccatttatga aaacgaataa tagatcacct 1492681 ttttaagggc aatccagaga ggttgcaaag aggtgcacaa caaaggccca aaaagtattc 1492741 ggcaggtctt tgtatgcctc tttgcgtaaa aaagcaaaga ggttttttta tacagtcatt 1492801 gagtcatcct aaaatgaaag tcaacaatca gggggaaatc atcatgagta agaaaaaagt 1492861 aaatttaggg gtcagggatg tcccgacacc tttctcttgg gtttcattca gccttcagca 1492921 tttgtttgcc atgtttggct caaccatttt ggttccgaag ctcgtcggaa tgagtcctgc 1492981 tgtggcgttg gtgacaagcg gcatcggaac actggcgtac cttcttatta ccaaaggaca 1493041 aattccggcg tatctcggtt catccttcgc ctttatttct ccgatcattc tggtaaaagc 1493101 gaccggcggg ccgggagcgg caatggttgg agcgtttctt gcagggctgg tgtacgggct 1493161 gattgcctta ttgattaggc agcttggaac aggatggctg atgaagattc tcccgcctgt 1493221 agtcgtaggg cctgttatta tcgtcatcgg gctgggactg gcaagcactg cagtaaacat 1493281 ggcgatgtat gctgatccga acgcgagtga gttggtctac agcttaaagc actttagtgt 1493341 cgcaggagtt acgctggcaa ttacgattat ttgtgcgatt ttcttacgag ggtttttaag 1493401 cctgattccg gttctgatcg gaatcatcgg cggatacctg tttgccctta ctcaagggat 1493461 tgtcaacttc cagccggtgc ttgacgcgaa atggtttgca gtgcctgaat ttatcattcc 1493521 gttcaaagat tattcaccgt cagttacgct cggcatcgca gccgcaatgg ttcctgtcgc 1493581 atttgtcaca atgtcagagc atatcggcca ccaaatggtg ctgagcaagg ttgtcggaca 1493641 agacttcatt aaaaagccag gtcttcatcg ctctattatg ggtgacagtg tggcgacaat 1493701 cctcgcttcc ctgatcggcg gccctccgac aacgacttac ggagaaaaca ttggcgtgct 1493761 ggccatcaca agagtattca gcgtctttgt catcgggggc gcggcagtga ttgccctttg 1493821 cttcggcttt atcggcaaaa tttcagcgct gatcagttca gtgccgtcag cggtcatggg 1493881 aggcgtctcc ttcctgctgt tcggaatcat tgcttcaagc ggcctgagaa tgctgattga 1493941 caacaaaatt gattatgaaa acaacagaaa cctcattatt acatcagtta tccttgtcat 1494001 cggtgtagga ggcgctttta tccaagtgtc tcagggcgga ttccaagtgt caggaatggc 1494061 gcttgccgca attgtcggtg tcatcttaaa cctgattctt ccgcaggcga aggaagagca 1494121 ggcagacaca tctgaacaac atcatattta aaacctttta atgaaagtcc agagaggctt 1494181 ggaagggtta tgaagagaag gaagcttcaa tgctgccctc tatttaacca taccccgagt 1494241 ctatcttaga ccggggtttt ttttcagcct taagttgaaa agagagggga aagaacatga 1494301 agcatttaac gacgatgagt gaacttagca ctgaggaaat caaagatttg cttcaaacag 1494361 cacaagagct caaaagcgga aaaacagaca atcagcttac aggaaagttt gcagcaaacc 1494421 tgtttttcga accgagcacg agaacgcggt tcagctttga ggtcgcagaa aaaaagctgg 1494481 gcatgaatgt gcttaacctt gatggaacaa gcacaagcgt gcaaaaaggc gaaaccttat 1494541 atgacacgat ccggacgctt gaatcaatcg gtgtggacgt ctgcgtcatc aggcacagtg 1494601 aggatgagta ttatgaagag cttgtcagcc aggtgaacat tccgattctg aatgcgggag 1494661 acgggtgcgg ccagcatcca acacaatcac tgcttgattt aatgacgatt tatgaagagt 1494721 tcaatacgtt taaagggctt accgtctcca ttcacggcga catcaagcat agcagagtgg 1494781 caaggtcaaa tgcggaagtg ttgacaagat tgggtgcccg ggtcctattt tccggccctt 1494841 cggaatggca ggatgaagaa aatacattcg gcacgtatgt ctcaatggat gaagcagttg 1494901 agtcttccga tgttgtcatg ctgctgcgca ttcaaaatga acgacatcag tccgctgtca 1494961 gtcaggaagg ctatttaaac aaatacggct tgaccgtaga acgggctgag cgtatgaagc 1495021 ggcatgcgat catcatgcat cctgctccgg taaacagagg agtggagatt gatgacagct 1495081 tagtagaaag cgaaaaatca agaatcttca agcaaatgaa aaatggcgta tttatcagaa 1495141 tggcagtgat acagcgtgcc ttacaaacca atgtgaaaag aggagaagca gcgtatgtca 1495201 tatctcatta aaaacggctg gatactaaac gaaaatggtg aaaaaacaca agcggatatc 1495261 cgagtgactg gagaaaccat caccgcaatc ggcaagcttg atgcaacgga taatgaaacg 1495321 gtaattgatg caaaaggttt gctcgtttca cctgggtttg ttgatctcca cgtgcatttc 1495381 agagagccgg gcggagagaa aaaagaaact attgaaaccg gggcaaaagc agcggcgcgc 1495441 ggcggctata ctacagtagc agcaatgccg aatacgcggc cggttcctga tacaaaggag 1495501 cagatggaat gggtgcaaaa cagaattaaa gaaacatcat gcgtaagagt tcttccatat 1495561 gcatccatta cgatcagaca aatcggcgat gaaatgacaa actttgaagc gttaaaagaa 1495621 gccggggcat ttgcttttac agatgacggc gttggtatac agacagcagg aatgatgtat 1495681 gaagcgatga aacgggcagc cgcaattgac aaagcgattg ttgcacattg cgaggacaac 1495741 tccttaattt acggagggag cgtacatgag gggacattct ccaaagcgaa cgggctaaac 1495801 ggcattcctt ctgtgtgtga atcggttcat attgctcgcg atgtgctgct ggctgaggcg 1495861 gcaaactgcc attatcatgt atgccatatc agcacaaaag aatctgtcag agttgtacgc 1495921 gatgcgaaaa aagcgggaat cagagtgaca gcagaagtat cgccgcatca tttgctgctt 1495981 tgtgatgagg acatcccggg gctggacaca aactataaaa tgaatcctcc gctccgcagc 1496041 ccagaagaca gagctgcttt aattgaaggt cttttagacg gaacaattga ttttatcgca 1496101 acagaccatg caccgcatac ggaagaagag aagaacacag aaatgaagct ggcgccattc 1496161 ggaattgtcg gcttagaaac agcattcccg cttctttaca cacactttgt caaaaatggc 1496221 agctggtcac tgaagcagct gattgactac atgacaatca agccatgcga agcgttcggt 1496281 ctcccatatg gaacattaca aacggggcaa gctgcggaca ttacgttaat cgatttagaa 1496341 aaagaagcag ttatagacaa agagacattt ttatcaaaag gaaaaaatac accattcaac 1496401 ggcatcagtt gcaccggctg gccggtcgct acaattgcgg cagggaagct tgcttatgaa 1496461 gaggggagac ttgtcaaatg aagagacgat tagtactgga aaacggagcg gtattcgagg 1496521 gagaagcttt cggaagctta gaacacaaca tgggagaagt cgtttttaat actgggatga 1496581 caggctatca ggaaatttta tctgatcctt cttactgcgg acagatcgta acattaacat 1496641 acccgcttat cggaaattac ggcattaacc gtgatgattt tgaatccatt accccttttg 1496701 tcaaagggct gatcatcaaa gaattatgtg agctgccttc caactggcgt tcagcataca 1496761 ccttagacga gtatttaaaa atgaaaaaca ttcccggact ccagggaatt gatacaagga 1496821 agctgacaag aatgatccgc acggcaggcg cgctaaaagg aacattcgct tcatctgatg 1496881 aagatatcga agcagtgctg aaaagactga acgaaacgga attgccaaga aatcaagtat 1496941 cccaagtatc agcaaaaaca gcatatccga gcccgggaag aggcaaacgc attgtcttgg 1497001 ttgacttcgg catgaaacac gggattctaa gagagctgaa caaacggaaa tgtgacgtca 1497061 tcgttgtgcc ttacaacatt acagcggaag aggtgcttca gctgaaaccg gacggtatca 1497121 tgctttctaa cggacctgga gacccgaagg atgtgcctga agcgattgaa atgattaaag 1497181 gtgttcttgg aaaagtgcca ttattcggaa tatgtctcgg ccaccaatta ttcgcgctgg 1497241 cgtgcggggc gaatactgaa aaaatgaaat tcggccacag gggctcaaac cacccggtaa 1497301 aagagctggc tacaggaaaa gttgccttaa catctcaaaa ccatggatat acagtttcgt 1497361 ctatcagtaa aacagaactg gaagtgacgc atatcgcaat taacgacgat acgattgaag 1497421 ggctgaagca taaaacattg ccggcattta cggttcaata tcatcccgaa gcctcacctg 1497481 gtcctgagga tgccaaccat ctatttgaca gattcatcga aatgatcgaa acaacagaga 1497541 aagaagggga agcggtatgc caaaacgcgt agacattaac aaaattttag taatcggatc 1497601 tggaccgatc atcatcggcc aagcagcaga atttgactat gcgggaacac aagcctgtct 1497661 tgctttgaaa gaagaaggct atgaagtcat ccttgtcaac tcaaaccctg caacgatcat 1497721 gacagataca gaaatggctg accgggttta catcgaaccg ctcacacctg aattcctgac 1497781 acgaatcatc agaaaagagc gcccggatgc cattcttcct acactcggag gccaaaccgg 1497841 tttgaatctt gcggttgagc tttctgaaag aggcgttttg gcagaatgcg gcgtcgaagt 1497901 gcttggcacg aaactgtctg cgattcagca agctgaagac cgtgacttgt tcagaacatt 1497961 aatgaatgaa ctgaatgaac cggtgcctga aagtgagatt atccactccc ttgaagaagc 1498021 agaaaaattc gtcagtcaaa ttggattccc tgtcattgtc cgcccggcat atacattagg 1498081 cggaacaggc ggaggcatct gctcgaatga aacagagcta aaagaaatcg ttgagaacgg 1498141 cttgaaatta agcccggtac accaatgtct gcttgaaaaa agcatcgccg gctataaaga 1498201 aatcgagtat gaagtcatga gagacagcca ggatcacgcc attgtcgttt gtaacatgga 1498261 aaacattgat ccagttggaa tccatactgg agacagtatt gttgtcgcgc cgagccaaac 1498321 gctcagcgat cgcgaatatc agctcttgcg gaatgtatcg ttaaaactga ttcgcgcgct 1498381 tgggatcgaa ggcggatgta atgtccagct cgccttagat ccagacagct tccaatatta 1498441 cattattgaa gtaaatccgc gtgtcagccg ttcatctgcc cttgcatcaa aagcaacggg 1498501 gtacccgatt gcaaagctcg ctgctaaaat tgcagtcgga ctttcattag atgaaatgat 1498561 gaacccggtg acaggaaaaa catatgcagc atttgaacct gctcttgact atgtcgtatc 1498621 caaaattccg cgctggccgt ttgataagtt tgaatcagca aacagaaagc ttggcacgca 1498681 aatgaaagcg acaggtgagg tcatggcaat cggccgcacg cttgaagagt cattgctgaa 1498741 ggcagtgcga tcactggaag cggatgtgta tcatcttgaa ttgaaggacg ccgctgacat 1498801 ttcagatgag cttcttgaaa agcgaattaa aaaggccggt gatgaacgct tattctactt 1498861 agctgaagcg tacagaagag gctacacggt agaagacctc catgaatttt ccgctatcga 1498921 tgtcttcttc ttgcataagc tgttcggaat cgtacagttt gaaaaagaat tgaaggccaa 1498981 tgcgggcgat acagatgtgc tgagacgggc aaaagaactc ggcttctctg atcagtacat 1499041 cagccgtgaa tggaaaatga aagaatctga gctttacagc ttgagaaaac aagcggggat 1499101 tgcgccggta ttcaaaatgg tagatacatg cgcggcggaa tttgagtcag aaacgccata 1499161 cttctatagc acatatgaag aagaaaatga atctgtcgtt acagataaga aaagtgtgat 1499221 ggtgcttggt tcgggtccga ttcgaatcgg tcagggtgtc gagttcgact atgcgacggt 1499281 tcactctgta tgggcaatta aacaagcagg ctatgaagcc attattgtca acaacaaccc 1499341 ggaaaccgtt tcaacagact tcagcatctc agacaagctg tattttgaac cgcttacgat 1499401 tgaagatgtc atgcacatca ttgacctcga acagccaatg ggcgttgtcg tacaatttgg 1499461 cggacaaact gcgattaacc ttgctgacga gctttctgca cgcggagtga aaatccttgg 1499521 aacttcatta gaagatttag accgtgccga agaccgggat aaatttgaac aagcgcttgg 1499581 agaacttggt gttcctcagc cgcttggcaa aacagcgaca tcagttaatc aggcggtaag 1499641 catcgcaagt gatatcggtt atccggtact ggtacgccct tcctatgtac ttggcggccg 1499701 ggcgatggag attgtttacc atgaagagga actgcttcat tacatgaaaa atgcagtcaa 1499761 aatcaatcca cagcaccctg tattaattga tagatacttg accggaaaag aaattgaagt 1499821 cgatgcagta tccgacggtg aaacagtcgt cattccggga attatggagc acattgaacg 1499881 tgcgggcgtt cactccggag actcaatcgc tgtttatccg cctcagtctc tcacagagga 1499941 cattaagaaa aaaattgaac aatacacgat cgcattggct aaagggctga atattgtcgg 1500001 tttgctcaat attcaattcg tcttgtcgca aggcgaggtg tacgtgctag aagtgaatcc 1500061 gagatcaagc agaaccgtac cgtttttaag caaaattacg ggtatcccaa tggcgaatct 1500121 cgcaacaaaa atcattcttg gtcaaaagct ggctgcgttt ggctatacag agggccttca 1500181 gcctgaacag caaggtgtat ttgtaaaagc gccggtcttc tcctttgcca agctgagaag 1500241 agtggatatt acgttagggc ctgaaatgaa atcaacaggt gaagtcatgg ggaaagattc 1500301 gacacttgaa aaggcgctct acaaagcctt gatcgcttca ggtattcaaa tcccgaacta 1500361 cggttccgtg cttttaacag tagctgataa ggacaaagaa gaagggcttg ccattgctaa 1500421 gcggttccac gcgatcggct acaacatttt agcgacggaa ggaacggcag gctacctgaa 1500481 agaagcttcc attccagcga aggtcgtcgg aaaaatcggt caggatggcc cgaacttgct 1500541 tgatgtcatc agaaacggag aagcgcagtt tgtcatcaat acgctgacaa aaggaaagca 1500601 gccggcaaga gacggtttta gaatcagacg tgaatcagta gaaaatggtg ttgcctgcct 1500661 aacatcttta gatacggcag aggcgatatt gcgagtgctg gaaagcatga cattccgtgc 1500721 tgatcaaatg ccggcagtca acacaaatca ggaggcggca gtcactatat gaaaaaagcg 1500781 tatttgacag tatgttctaa ccagcaaatt gcagaccggg tgtttcaaat ggttctgaaa 1500841 ggggagcttg tccaagggtt tacaacccct ggacagttcc ttcatcttaa agtgagcgaa 1500901 gcggttacgc ctcttttgag aaggccgatc agcatcgcag acgtcaactt tgaaaaaaat 1500961 gaagtcacca tcatttatcg ggtagatggg gaagggacaa gactcttgtc actgaagcag 1501021 cagggagaac ttgtggatgt cctcgggcct ttgggaaatg gctttcctgt taatgaagtt 1501081 caacccggaa agacggcttt gctggtagga ggcggagtag gtgtgccgcc tctccaagag 1501141 ctgtcgaaac gcttgattga aaaaggggta aatgtcatcc acgttttagg attccaatcg 1501201 gcaaaggatg ttttttacga ggaagaatgc cggcagtacg gagacacgta tgtggcaaca 1501261 gctgacggaa gctacgggga aaccggattt gtcacagatg tgattaaacg gaaaaagcta 1501321 gagtttgata tcctcctcag ctgcgggccg acaccgatgc tcaaggcgtt aaaacaggaa 1501381 tatgcccata aagaagtata tctgtccatg gaggaacgaa tgggctgcgg aatcggcgca 1501441 tgcttcgcgt gtgtgtgcca tacaaacgaa agtgagacat cctatgtaaa agtatgtctc 1501501 gacgggcctg tatttaaagc tcaggaggtg gcgctgtaat gctagaggtg aaattgccgg 1501561 gacttgattt gaaaaaccca atcattcctg catcaggctg cttcggtttt ggaaaagaat 1501621 tttcacgttt ttatgatttg tcttgtcttg gagctatcat gattaaggct acgacaaagg 1501681 agccgcgctt tgggaatccg acgccgcggg tagctgagac tggtgctgga atgctcaatg 1501741 cgatcggtct ccaaaatccg gggctggata gtgtgttgca tcatgagctg ccgtggcttg 1501801 agcagtttga tacaccgatc attgccaatg tcgcaggttc tcaagtcgat gattatgttg 1501861 aagtcgcaga acatatcagc aaagcgccta atgttcatgc tcttgaattg aatatttcct 1501921 gcccgaatgt gaaaacaggc ggaatcgctt ttggcacgaa tcctgaaatg gctgccgatt 1501981 tgacaaaagc ggtgaaagag gtttcggatg tacccgttta tgtgaagcta tccccgaacg 1502041 tggctaatat cacagaaatt gcattagcga tcgaggaagc gggagcggac ggtcttacga 1502101 tgatcaacac actaatcggc atgagactcg atttaaaaac cggcaaaccg atattagcga 1502161 ataaaacagg gggactttcg ggccctgctg tgaagccggt tgccattcgc atggtgtatg 1502221 aagtcagcca gatggtcaac atcccgatta tcggaatggg aggcgtgcaa acggctgaag 1502281 atgccctgga atttcttctc gcgggagcaa gcgcagtcgc tgtcggaaca gcaaactttg 1502341 tgaatccttt tgcatgtcca gagattattg aacagctccc atctgttttg ctccaatacg 1502401 gctatcaatc aattgaagaa tgcatcggaa ggagctggaa tcatgaaaaa caacctgccc 1502461 atcatcgcgc ttgattttgc gtcagctgaa gaaacacttg cgttcttagc gccttttcag 1502521 caagaaccgt tatttgtaaa ggttgggatg gagctttttt atcaagaagg gccatctatc 1502581 gtgaaacaac taaaagaaag aaactgcgag ctatttttag atctaaagct tcatgacatc 1502641 ccgactactg taaacaaagc gatgaagcgc cttgccagtc ttggagtaga cctcgtcaat 1502701 gttcatgctg ccgggggcaa aaaaatgatg caggcagctc tcgaaggctt agaagaaggt 1502761 acgccggctg gaaaaaaacg tccgtcactt atcgcggtaa cccagctgac aagcacatct 1502821 gaacaaatca tgaaagatga actgctgatc gaaaagtctc tgattgatac ggttgtgcac 1502881 tacagcaaac aggcggaaga aagcggactg gatggagtgg tctgctctgt tcatgaagca 1502941 aaagccattt accaagcggt gtcgccttca tttctgactg tcactccggg gatcagaatg 1503001 tcagaggacg ctgcgaatga ccaagttcgc gtagcgacgc ctgccattgc aagagagaaa 1503061 ggttcatcag cgattgtagt aggacgctcg attacaaaag cggaagaccc ggtaaaagcc 1503121 tataaggctg tcagacttga atgggaggga atcaaatctt gaaacaaatc atcgcaaaac 1503181 atctattaga catccaagct gtatttttac gcccgaacga gccgttcaca tgggcaagcg 1503241 gcattttatc accgatctac tgtgacaacc gccttacgct atctttccca gaggtcagaa 1503301 acgatgttgc ttcaggtatc agcaagcttg ttaaagagca ttttcctgaa gctgaaatga 1503361 ttgcgggaac agcaactgcc ggtattcctc atgctgctct tgcggcggac catttgaatc 1503421 ttccgatgtg ttatgtgagg agcaagccga aggcgcacgg aaaaggcaat cagattgagg 1503481 gagctgtgca agaagggcaa aaaacagtcg tcattgaaga cttaatttcc acaggaggca 1503541 gcgtgcttga agcttgtgca gctttacaag cggccggctg tgaagtgctt ggtgtcgtct 1503601 caatctttac gtacggactt cctaaagcgg aggaagcctt cgcaaaggca gaactgccat 1503661 actactcatt aaccgattat gatacgctca cagaggtcgc gcttgaaaac ggaaatattc 1503721 attcagatga tctaaaaaag ctgcaaacat ggaaacgaaa tcccgagtca aaagattggt 1503781 ttaaaaaata aaaaataaat tcaaatgatg taaagaggct tcaaagcctt gctgtacttg 1503841 aaaacaggct gtgaggcctg tttttttatt aatcctataa aaaaagtcgg gttgacttat 1503901 gttagaattg tgctaaaatt tactacaaat ctaaaaactt atcaagagcg gctgagggac 1503961 tggacctatg aagcccggca acctgcatag tttgtaaggt gctacttcca gcaaaatgaa 1504021 ttccattttg aaagataagg gctgcatgct gttcctgtct ttctttccgc cggattgaaa 1504081 gttttttatt ttaagaggta aaaaggctat ctgtatatca gcagccgcga atcacattac 1504141 atgggaaaag acaaccggca gaaagctact gtttgtttgt ctccgaaagg aggaaagaag 1504201 aaatgttaac gtatgataat tgggaagaac caacgattac atttccggaa gacgatcctt 1504261 ataaaggagc gctgtcagtt ttaaaatggg catacggcca ttacggcgat cagcttgttt 1504321 atgcctgcag tttcggaatt gagggaatcg ttctgattga cttaatttat aaagtgaaaa 1504381 aagacgcaga gattgtgttt cttgatacag gacttcattt taaagaaacc tatgaaacaa 1504441 ttgaacgagt gaaagagcgt tatccgggtc ttaatatcat cctgaaaaaa ccagatctca 1504501 cccttgagga acaagccgaa gaacatggtg acaaactatg ggaaagagag ccgaatcagt 1504561 gctgctatct tagaaaggtc gttcctttaa gagaggcgct ttcaggacat ccagcctggc 1504621 tttccggcct gcgccgtgat caagggccaa gccgtgccaa tacgaatttc ttaaacaaag 1504681 atgaaaaatt caagtcagta aaagtttgcc cgcttatcca ttggacttgg aaagacattt 1504741 ggagatatac atcccggaat gaactggact acaatccgct tcatgaccaa ggctatccaa 1504801 gtattggctg tgcgccttgc acttctcccg cttttacagc agaagatttg cgctcaggca 1504861 gatggaatgg tatggcgaaa acagaatgcg gactgcatga ataaggagct gcaaaatgga 1504921 attagccgct attttattta gcttgttttt cgcgatgaat attggtgcaa gcggcgctgc 1504981 agcttcgatg ggggttgctt acggctccgg agccatcaaa aagaaaactt acgctttgat 1505041 cctatgcgca gtcggtgtct ttgccggggc ggtcattggc ggaggcgagg ttgtaaaaac 1505101 aatcagctcc ggcattattc ctgagcagac gattacactg acgattgttt gcatcattat 1505161 tggagctgct gccctgtcgc tctttactgc taatctgctc ggcattcctt tgtcgacaag 1505221 tgaagtaaca gtcggcgcgg ttgtcggcgt gggagtggct tataaagtat tgtttgtgaa 1505281 caatcttctg atcattgtgt cattttgggt ttttgtcccg ctgttcgctt tcggcttcac 1505341 ctatttcgta tctaagctgt ttcgttattt taagattgaa gtaaaatctt ctaaaaagca 1505401 aaaaatcctc ggcattgttt tgttagttgc cggatttttc gaagcattct ctgccggcat 1505461 gaataacgtg gcgaatgctg ttggcccgtt agtagctgcc ggtgtgcttg atgtcggaaa 1505521 aggaaccttg tatggaggag cttttgttgc tcttggcgca ctgttattag gccggcgagt 1505581 gctagaaaca aacgggaaga aaattacgag gttctccaaa ggggaaggca ttctcttatc 1505641 cggtacagga gcgggactgg tgatcatcag ttctgtattt gggatgccgg tgcccttggc 1505701 gcaagtcacg tcatcgtcta ttatcggaat aggcatggcg aaaaacggtc cgaacgtgtt 1505761 ccataaacaa gttgttcaaa cgatgctgaa ggtatggatc gtatcgccgt ttttatcttt 1505821 atcgatttct tatctgcttg tatccttgtt tttaaaagca gattattatt cgatctttat 1505881 catggtaagt gtgcttttag cggcgggcgg tgccatcagc ctgacaaagg ccattcgtaa 1505941 agagagacgc tcagtccacg aacaaggcgg gggaatctga tcattaatct gagtaatttt 1506001 ataagttaac taggaggaga tggatattat gagcttagca ccacacggag gaacattagt 1506061 aaacagagta gatgaatcat atgatgtgag cggcattcaa aaagaaattg aacttgattt 1506121 aatttctttc gcggatttgg aattgatcgg tatcggtgca tacagcccga ttgaaggttt 1506181 ctttaatgaa aaagattacg tatcagtggt cgaaaacatg cgtctttctt ccggcgttgt 1506241 ctggtctctt ccaatcacgc ttccggtcga tgcgcaaaaa gcagcggaac tgtcacttgg 1506301 tgaaacggta aagttaacgt atgaaggaga aacttacggc gttatccaaa tcgaagacct 1506361 gtacgtgcct gacaaacaaa aagaagctgt caatgtgtac aaaacagatg aacaggagca 1506421 tcctggtgtt aaaaagctgt tcagccgcgg caatacatat gtcggcggac cgattacgtt 1506481 gattaaaaaa gcttcaaaac agttccctga atttacattt gaaccgtcag aaacgagacg 1506541 ccagtttgcg gaaaaaggct gggaaaccat tgtcggtttc caaacaagaa accctgttca 1506601 cagagcgcat gaatacattc aaaaaacggc tcttgaaaca gtagacggct tgttcttgaa 1506661 tccgttagta ggtgaaacaa aatctgatga cattccagct gatgtacgga tggaaagcta 1506721 ccaagtgctt cttgatcatt attacccgaa agatcgtgtt ttccttggtg tctttttagc 1506781 ggcgatgcgt tatgcaggcc cgagagaagc aattttccac gcgcttgtca gaaagaacta 1506841 cggctgcaca catttcatcg tcggccgtga tcatgcaggt gtaggcgact attacggaac 1506901 atacgaagca caggaactgt ttgacacatt taaacctgaa gaactcggaa ttacaccgct 1506961 gaaatttgag cacagcttct tctgtaaaaa atgcggaaat atgggaacag caaaaacttg 1507021 ccctcatggc agagagcatc acgtcatttt atcaggcact aaggtaagag gtatgctgag 1507081 agacggtgtg ctgccgcctg ctgaattcag tcgaaaagaa gtagtagaag tgttaatcaa 1507141 agggatgaag aaaaaagaag aagtaggcgt atcttaagga ggactggcag tgacaaatcg 1507201 cgatattgta tggcatgaag cctctatcac aaaagaagag tatcagcaaa aaaacaagca 1507261 taaaagctcc attctctggc tgacagggtt aagcggctca ggcaaatcaa ccattgccaa 1507321 cgccgctgcg agagaattgt ttgagcaagg ctaccaagtc attgtgctgg acggggataa 1507381 tatccgtcac ggcctaaata gggatcttgg tttttctgat gaagaccgaa aagaaaacat 1507441 ccgccggatc ggagaggtgg cgaagctttt tgttcagcag ggaaccattg tgattactgc 1507501 ttttatctct cctttccgcg aggacagaca acaggttcgc gagcttgtgg aagcgggcga 1507561 atttaatgaa gtctacatta aatgcgacct tgatatttgt gaacaaagag atccgaaagg 1507621 gctttacaaa aaagcaagaa acggcgagat tccgttcttt acaggaattg attctcctta 1507681 tgaagaaccg gaagctccag agctcgttct tgattcagga cagcatgacc gtgaagcgtg 1507741 taaaaatcag ctgatcgagt ttgttaaaca aaaattgagc tgaatatgat ctgctgcgtt 1507801 cttctcagat gccggaatgc aagcgagaac atcatcacag cgaatcttct ggaagaactc 1507861 gaatagatcg ggggaaatac gatggggaaa gtatatattg taggagcggg tcccggtgac 1507921 cctgatctgc tgacaattaa agcgctgaaa gccattgaaa aagctgatgt catcttatat 1507981 gacagattag taaataaaga gattttacaa tatgccaaag agcaagcaga cctgatctac 1508041 tgcgggaagc ttccggattt tcatacgatg aagcaggaaa ccatcaatcg atttcttgtg 1508101 aagtatgcgc aaaaagggaa aatggttgtc agactgaaag gcggagaccc ttttgtgttc 1508161 gggagaggag gggaagaagc ggaatgcctc tctgaaaatg gaattccgtt tgaaatcatt 1508221 cccggcatta cgtctggaat cgcggcagcc gcttatgccg ggattcctgt tacccatcgg 1508281 gatgcgggct ctaacgtcgc ttttgtaacg ggtcactata aaaaagaaga agattttgag 1508341 gaaaagtgga aagcgctggc tacaggaatt gatacacttg tcatctatat gggtatcaaa 1508401 aacgtgcagc agattgaaag aaaactcctt gaaaatggcc gggacggttc tacgccagca 1508461 gcctttattc attgggggac aacggacaag caaaaatctg ttttttgtac agttgacacc 1508521 ctttcagaaa cggtgataaa agaaaacatt acaaatccga gtttaattgt cattggaaat 1508581 gttgtaaatt atcactataa gctggaatgg tttgaatctg aactaaaaaa acaagattta 1508641 agcgaggcgt tgtaaaaatg aaacaagcaa ttttatatgt cggccacggc agccgggtca 1508701 aaaaagcgca gcaagaagcc gcagcctttt tggaaggatg caaggcccac atctctgtgc 1508761 cagtacaaga aatcagcttt ttagagcttc aggagccgac aattgagaca ggatttgaag 1508821 catgtgtgaa gcaaggtgcc actcatatcg cagtggtgcc tctgcttctt ttaacagctg 1508881 cgcatgcaaa acatgatatt ccggaagaaa ttgtccgtgt tgcatctcga tatccatcag 1508941 tccgtatttc atacggaaag ccgatcggga ttgacgaaga agtagtcaag gctgtatatc 1509001 accgaatgaa agacataggt gttccgtatg aaaatgccag agtggtgctc atcggaaggg 1509061 gaagttcaga tccagacgtc aaaagagacg taaccggaat tgctaatctt cttcaggaaa 1509121 tggttccagt gaaggaagtc attccgtgct ttttgacagc atgcggccct aattacaaag 1509181 aggttttttc agaacttgaa aaagatgacg gcataacaac ctttatcgtt ccatatttgc 1509241 tttttacggg tatgctgatg aatgaaatcg aacgagaggt tcagaaatta aaagcccata 1509301 atccgaacgt ctacctctct tcctatatcg gttttcatcc tcatgtgaaa aacgcatttt 1509361 tgaaccgtgt gagagaaact gcggcaaatt ctgagggaca atttgatttt gatggaggtt 1509421 catatgcttc cgctgcacat tagcctggaa aagaagaagg ttgtgattgc ggggggcgga 1509481 agcatcgctc tcagaaggct gaaaacggtg atttctgagg gagctgatat aacgcttgtc 1509541 agtccggatg tggaaccgga aatcaagcaa atggcagaag agcggcgtat caaatgggaa 1509601 aaacggacaa ttgaaaaaga agattatctc aatgctttct tcattattgc tgcgacggat 1509661 aatgcggcag tgaacaaaga aattgcccaa tccgcttcgc cttttcagct tgtcaattgt 1509721 gtcagtgacg ctgagcttgg caatgtatat atgccgaaaa tcgtaaaaag agggcatgtc 1509781 actgtgtctg tttctacaag cggagccagt ccaaagcaca cgaaagagct tgctgaaaac 1509841 gtggataagc tgattgacgg cgattttgtt gctgaagtga acaggcttta tcagatgaga 1509901 agaaagaaat aagccagagc atacaaatgc tctggctttt ctttatgcgg ctcagctttt 1509961 tttgagcttg atgacagtat cagcatcagg cgtgacaaag acggtatgct ggctgtcata 1510021 agtgacgaaa ccgggtttcg cgccgtttgg ttttttgaca tgcctgattt ttgtataatc 1510081 tacaggcact gaacttgaat ctttagcttt tgaaaaataa gctgcaattg tcgcggcttc 1510141 catgattgtt tgctcatcag gttcgctgct tctgatcaca acgtgggagc cgggaatgtc 1510201 cttcgtgtga agccagatat cgtctctggc cgccactctt gtcgttaaat attcattttg 1510261 acgattgttc ttacccacta aaattgtcag ccctgaggtg gattcatatg tttctaacac 1510321 cggattgtgc ggtttttgct ttttctggcc tttttgctgc ttagggcgta aatatttgcc 1510381 ctcaacaagc tcttccctga tttcgctgat atcccgggga gaagcggacg aaagctgctg 1510441 aatcagctga tcaaaatatt cgatctcttc ctgtgccagc ctgatttgct cctcgacaac 1510501 tgcgaccgaa tttttcgctt tctgatactt cgtgaaatag gcctgtgcgt tttcagaagg 1510561 cgttttgttc gggtttaaag gaatcgtgat tgtcgggctt tcttcatcat aataattgat 1510621 gacctcagcc tgtttatcac cttttttcag catatataaa ttagcggtta aaagctctcc 1510681 gtaaagctga aattccttcg cgttttccga atactccagg gttttctcta attttttgat 1510741 tttgttggca ttcttcttcc gttcgttcac aacaaaacgc tcaagatcct gagcctgttg 1510801 cttaacccgg tctcgttcag cttttccgaa ataaaaacgg tcgagcagtt cgcttaatga 1510861 atcaaaacgg cgcgcttcgc cctttagatg agtcagctcc agcagataaa aatattcctt 1510921 tccgtttaca gtcgtaatgt tgggaatgaa acggtgctct ttcacttcgg caaacagtgc 1510981 cagcaacgct tttggcagtg tgactttgtt ggcaaggcct gctctgtgaa ccgcttcttt 1511041 ggcgaaaagc ggagacacgc ctgaaaagtg gtcgacaatt tgtttatcaa gccttccttc 1511101 ttgaaagctg aggtgacgca aaatatcatc ttctgacgcc tcaagaggcg atattttgtc 1511161 ctgagcaggc ggaagcttat aatcttggcc gggcagtact gtacggtagc tgttcattga 1511221 cggtgataaa tgcttaagtc cgtcgataat cacattttct gctgcgtcag tcaaaatgat 1511281 attgctgtgg cggcccataa tttctacata aagctttcgt acggtttcat cgccaatttc 1511341 gtttcggctt ttgatatgaa aaatcataat gcggtctaag cccgcttgtt caattttctc 1511401 aatgaatccg ccttcgatat gctttctcag caacatgcaa aacattggcg gttcgcttgg 1511461 attttcataa gcttgtgccg tgatatgcac ccgtgaatag ctcggatgtg ccgataataa 1511521 tagtttttgg ttttttccct tggcacggat gtggaaaatc acatcgtgct tatatggctg 1511581 atggattttt gtaattcgtc cgcccattat tttctcgtta agttcgtgtg tcattccgta 1511641 tgtaaacatg ccatcaaacg acatatgcaa tacaccctct cattcttcct gcattcgata 1511701 attatagcat gaaatgggac gagtcagaat aagcatgctt atagagtgat atctctataa 1511761 gagagcaggg gagtggacga gcggaatgaa gtttcatgaa atgggacaaa cagatttact 1511821 agaggcaacc aatacgtcca tgaaacaagg attaacagaa aaagaggtaa aaaaacgcct 1511881 tgacaagcat ggaccaaacg agctgcaaga agggaaaaaa acttcagcgc ttctcttgtt 1511941 tttcgcgcag ttcaaagatt ttatggtgct tgtgcttctg gcggcaacgt taatctcagg 1512001 atttcttggt gaatatgtag atgcggttgc gattattgcg attgtgtttg tgaatggcat 1512061 actcggtttc tttcaagaaa ggcgtgctga gcaatctctt caggctttaa aagagctttc 1512121 aacaccgcac gtcatggcac tcagggaagg aagctggaca aagattcctt ctaaggaact 1512181 ggtgccgggt gatattgtga aatttacgag cggggacaga attggcgcag acgttcgaat 1512241 tgttgaagcg agaagccttg aaatagaaga atcagcgcta accggggaat caatcccggt 1512301 tgtgaagcat gctgataaat tgaaaaaacc ggatgtttca ctcggcgata ttaccaatat 1512361 ggcatttatg ggtacgattg tgacccgcgg cagcggtgtc ggggttgtcg tcgggacagg 1512421 aatgaatacg gctatgggga aaattgccga catgcttgaa tcggcaggga cattgtcaac 1512481 cccgctgcaa agaagactgg agcagctcgg gaagattttg attgttgttg cattgcttct 1512541 gaccgtactt gtcgttgctg tcggtgttat tcagggtcat gatctgtaca gtatgttttt 1512601 agcaggtgtc tcgttagcgg tagccgctat tccggagggg ctgccggcga ttgtgacagt 1512661 ggcgctttcg cttggtgtac agaggatgat taaacaaaaa tccattgtta gaaagcttcc 1512721 tgctgttgaa acgcttgggt gtgcgtctat catttgctca gataaaacag ggacaatgac 1512781 ccaaaacaaa atgacagtga cgcatgtctg gtccggaggg aaaacatgga gagtggcagg 1512841 ggccggctat gaaccgaaag gaagcttcac actaaacgaa aaagagatca gtgtcaatga 1512901 acataagccg cttcagcaga tgcttctgtt cggagcgctt tgtaacaact ccaatattga 1512961 gaaaagagac ggcgaatatg tgcttgacgg agatccgaca gagggagcgc tgctcaccgc 1513021 ggcaagaaaa ggcggttttt caaaggagtt tgttgaatct aattacagag tgattgaaga 1513081 atttccgttt gattccgcac ggaaaatgat gactgtcatc gtagagaatc aagacagaaa 1513141 gcgctatatc attacaaaag gtgcgccgga tgtactcatg cagcgatctt cccgtattta 1513201 ttatgatggc tcagcggctc ttttttcaaa tgaaagaaaa gcagaaacag aggcggtatt 1513261 aagacatttg gcatcacagg cgctcagaac gatagcggtc gcctacaggc cgataaaagc 1513321 aggcgaaaca ccgtcaatgg agcaggcgga aaaagatctg accatgcttg gcctttcagg 1513381 tatcattgat cccccgcggc cggaagtcag acaggcgatt aaagaatgcc gtgaagcggg 1513441 aattaagacc gtcatgatta caggtgatca tgtagaaacc gctaaagcga tagcgaaaga 1513501 cttgcgcctc cttccgaaaa gcggcaaaat catggacggc aagatgctga atgaactttc 1513561 tcaagaagag ctttctcatg tggtggagga tgtgtatgta tttgcccgcg tttcccctga 1513621 acataaacta aaaatcgtaa aagcctatca ggagaacggg catattgtgg cgatgacggg 1513681 agacggcgtc aatgatgctc ctgccattaa acaggctgat atcggcgtct ctatgggcat 1513741 taccgggaca gatgtggcca aagaagcatc atctcttgtt ctcgtggatg ataattttgc 1513801 gacgattaaa tcagcgataa aagaaggcag gaacatctac gaaaatatca ggaagtttat 1513861 cagatacctg ttggcgtcta acgtcggaga aatccttgtc atgctgtttg cgatgctgct 1513921 tgcccttcct ttaccgctgg ttccgattca gattttgtgg gtcaacttgg tgacggacgg 1513981 attgccggca atggcgctcg gcatggatca gccggaagga gacgtcatga agcgcaagcc 1514041 ccgtcatccg aaagaagggg tatttgcccg caagctagga tggaaggtcg tttccagagg 1514101 atttttaatc ggagttgcca ctattttagc gtttatcatt gtgtaccacc gcaatccgga 1514161 aaacttggct tatgcccaga cgatcgcgtt tgccacattg gtgctcgctc agcttattca 1514221 cgtgtttgac tgccgcagcg aaacttctgt tttctctaga aatccgtttc aaaacctgta 1514281 tttaatcggc gcggtattgt catccatttt gctgatgctt gtagtaatct actatccgcc 1514341 gcttcagccg attttccata ctgtagccat cacgccgggg gactggatgc tcgtcatcgg 1514401 tatgtccgcc atccctactt ttttgctggc ggggtcactt ttaacaagaa aaaaataaat 1514461 tcatatgata taatcttagg ggtaatagcg tgtctattgc ccttttatta tgagaacagg 1514521 gaagaattgg gtgttttaaa atgatacgaa gtatgacagg cttcggcagt gcaagcaaaa 1514581 cacaagacga tctctctgta agcgttgaac ttaaatctgt gaactacaga tttaaagaag 1514641 tgaacgctcg tttgccaagg cctttgctat attttgaaga taagctgaaa cagaccattc 1514701 tgcagcatat tcagcgcgga agaattgagc ttttcgtatc cgttgacagc gatatgcttg 1514761 ttgagaaaag gcttgaaatt gattggccgc tgctcgatga gtttgtcgca gccgcgagag 1514821 atatgaagaa gcggtatcaa ttgtctgcag agcccgatgt aatggatttc tttaagcttg 1514881 atcatgtcgt ccaggttcat gaagaacaga cgcaaaatga caagctggag gcgttgatca 1514941 tcgatgctgc agaagaagcg gtaaaaggtc tctgtgaaat gcgtgaaaaa gaggggctgc 1515001 tcttagcgaa agactgcctg atgcatattg atcagcttga agagctggtg agagaaactg 1515061 aattgctggc tgcagatgtc gtatctcgtt accgggaacg gctgtatgcc agaatcaaag 1515121 aatggactga agacgtatta gacgagagcc ggcttgtaac agaatgcgct atttttgcag 1515181 accgctctga tatcactgaa gagattacaa ggctgaagag ccacttcgcc cagtttcgtg 1515241 atatattagc tagtggcgga gctgtcgggc gcaaactcga ctttcttgtt caggagctca 1515301 atcgggaagc aaatacgatc ggctcaaaag caaatgatca tcagatcaca aagcttgtcg 1515361 ttgaaatgaa aagttctatt gaaaaaataa aagaacaagt gcaaaatata gaatagtgac 1515421 tgtgcgtatt gtttacagac ggtcttacta ggctaaacta gagacgtcta ttttacaggg 1515481 ggaacgtaga agatgacgat taaactgatt aatatcggat ttggcaatat catctccgcc 1515541 aatcggatga tttcgattgt cagcccggag tctgcgccaa tcaaacggat gattcaggat 1515601 gcaagagacc gcggaatgct aattgacgct acatacggac gaagaacccg tgcagttgtc 1515661 gtcatggata gtgatcacat tatcttatct gccgtccagc ctgagacagt tgcacacaga 1515721 ctttctgtta aagaagaaat tatggatgaa gggcaggggt aattgccgca tgaaagaaag 1515781 agggttatta atcgttctct caggtccctc aggagttggt aaaggaacgg ttcgacaagc 1515841 gatcttttcg caggaagaca caaaatttga atattcgatt tcagtaacca caagaagtcc 1515901 aagagagggc gaagtgaacg gagtcgatta ttttttcaaa acaagagacg aattcgagca 1515961 aatgattgcg gacaacaagc tgcttgaatg ggcagagtat gtcggcaatt attacggcac 1516021 gccagtcgat tatgttgaac agacgcttca agatggaaaa gacgtctttt tagaaattga 1516081 agttcaaggg gctcttcaag tgagaaatgc tttcccggaa ggcctgttta ttttccttgc 1516141 gcctccaagc ctttctgaac tgaaaaacag aatcgtgaca cgaggaacag aaacagacgc 1516201 tctgattgaa aatcgaatga aagccgcaaa agctgagatc gaaatgatgg atgcttatga 1516261 ctatgtcgtt gaaaacgata atgtcgaaac ggcttgcgat aaaatcaaag caatcgttct 1516321 tgctgaacat ttgaagcgtg aacgcgttgc accaagatat aagaaaatgc tggaggttga 1516381 ataatcaatg ttagatccgt caattgattc tttaatgaat aaattagatt caaaatatac 1516441 gctggtgact gtttctgcga gacgtgcccg tgaaatgcaa atcaaaaaag accaaatgat 1516501 tgaacatacg atttcacaca aatatgtagg caaagcttta gaagaaattg atgcaggcct 1516561 gctttcgttt gaaaaggaag accgcgaata gtagcacaag tagcaaccta tatcatgtag 1516621 gttgttattt ttttccgtgc ggttttgtaa agtgcagagg gggagaattc attgcttaac 1516681 aatcgaaatg tgttactttg cgtgagtgga ggcatcgctg tttataaagc ctgtgcgtta 1516741 acgagcaagc tggttcaggc aggagcaaat gtcaaagtga ttatgactga atccgcttgc 1516801 cgattcgttt caccgctgac atttcaggca ttgagccgcc acgaagtcta tacagataca 1516861 tttaaagaac aaaatccaag cgtcatttct catattgatg ccgcagactg ggccgacttg 1516921 attatcgtag cgccggctac ggctaatgtg attggaaaac tggcaaacgg catcgctgat 1516981 gatatgctga cgacaacatt gttggcagca acggctcccg tttggatcgc gccggcaatg 1517041 aacgttcata tgtatgacca cccggcagtc aaacgaaaca tttctgttct ttatcaggac 1517101 ggttattgtt ttattgagcc aagtgagggc tatttagcat gcggttacgt aggaaaaggc 1517161 agattggaag agccggaaaa catcgtaaag ctggccgaaa aacattttgc tgaagaaaca 1517221 tccgctcctt tagaaggcaa gcatgtggtc attacagccg gcccaacgcg ggaagcgatt 1517281 gatcctgtcc ggttttttac caataaatcg acgggcaaaa tgggctacgc actggcggag 1517341 gctgctgttc agctcggcgc acgggtaatc ttaatttctg ggcctgtttc acttgatcag 1517401 cctaaaggcc ttgctgagtt tatccctgtt caatcggctg cggatatgcg cgaagctgtg 1517461 ctctctgtgt atgacgcaag cgatatagtc attaaaacag ctgcggtagc cgattttacg 1517521 ccgaaaacag tatttgacca taaaatgaaa aaacaagacg gcggcatgac cttagaactg 1517581 aaaagaacag tcgatatttt gaaagaattg ggcgagaaaa agaaagagca gattttggtc 1517641 ggatttgccg ccgaaacaca agacattgaa cactatgcac gtaaaaagct cgccgctaaa 1517701 aaccttgatt tgattgtggc aaatgatgtg aaagcaaatg gggccggttt tggtgctgat 1517761 acgaatatcg tgacaatctt tttcaaagac gggcataaac gcgaactccc gattatgtct 1517821 aagctcgatg tttcttttga aatccttcag gagatcgcag ccctctcaaa acaaaccgga 1517881 gagcgctcat gaattttgca gaagtcatcg ttgatgtcag caccaaaaat atagacaggc 1517941 cttttgatta taaaatccca gaccatctga agggcatgat caaaacgggg atgcgggtca 1518001 ttgttccgtt tggcccccgt aagattcaag ggtttgtgac agcagtcaaa gaagcatctg 1518061 acctatcggg aaaatctgtc aaggaagtag aggatttatt agatcttaca cctgttctga 1518121 cagaggagct tatgattctg tcatcatggc tgtcagacaa aacgctgtct tttaaaataa 1518181 cggcgcttca agcaatgctg cctgccgcct taaaggcgaa atatgaaaaa gaattaaaaa 1518241 ttgcacacgg agccgatctt ccgccgcaag tggaacggct gttttctgaa acaaagacgc 1518301 tgctgtattc agatataccc gatcatgaga cgctgaaact gattcaaagg catgttcaaa 1518361 aaggggacat tgacgtgacg tataaagtcg cgcaaaaaac caataaaaaa atggtcaggc 1518421 atattcaggc aaatgcgagt aaagaagagc ttgctaagca ggctgaggga ttgtcccgcc 1518481 aagcagcaaa acagcaggcg attcttcact ttctcatctc tgagccggaa ggtgtgaaaa 1518541 ttcctgcggc ggaattgtgc aaaaaaacgg acacgagctc tgcaaccatc aaaaccctta 1518601 tccaaaaagg gcttttgaag gaaagctatg aagaggttta cagagatccc tatcaggaca 1518661 aaatgttcaa aaaaacagag cccctgccgc tgacagacga acagagggct gccttcgagc 1518721 ccatacgcga gacattggac agcgatgagc ataaagtgtt cctccttcac ggcgtgacag 1518781 gaagcggaaa aaccgaaatt tatctgcaat caattgaaaa agtactggcg aaaggaaaag 1518841 aagccatcgt cctcgtaccg gaaatatcgc tgacgccgca aatggtcaac cgcttcaagg 1518901 gccgcttcgg ctcccaggtg gcagtcatgc acagcggttt atccacagga gaaaaatatg 1518961 acgagtggcg taaaatccac cggaaggaag tacggcttgt cgtcggtgcc agatccgcca 1519021 tttttgctcc gtttgaaaat ctcggaatga taatcatcga tgaagagcac gagtcttcct 1519081 ataaacagga agaaatgccg cgctatcatg cgaaagaggt ggcaatcaag cgggctgagc 1519141 atcacagctg cccggttgta ttagggagtg ctacgccgac attagaatca tatgctagag 1519201 cgcaaaaggg cgtatacgag cttctttcac tgaagcaccg tgttaaccat cgggtgatgc 1519261 ccgaggtttc gcttgtcgat atgagagagg agcttagaaa cggcaatcgc tcgatgtttt 1519321 cagttgaatt gatggaaaag cttgaagaaa cgattgccaa gggtgagcag gcggtgctgt 1519381 ttttaaataa gaggggctac tcttcctttg tgatgtgcag ggattgcggc tatgtcccgc 1519441 aatgcccgca ctgcgacatt tccatgacgt atcatcgtta cggccaaagg ctgaaatgcc 1519501 attattgcgg acatgaagag cctgttccgc acacttgtcc tgaatgcgca agcgagcata 1519561 tccgcttttt cggaacggga acacagcgag tggaggaaga gctgacaaaa gtgctgccaa 1519621 gtgcgagagt gattcggatg gatgttgaca cgacatcacg gaaaggcgcc catgaaaaat 1519681 tactgtcagc tttcggagaa ggaaaagcgg atattcttct cggaacgcaa atgatcgcga 1519741 aagggcttga ttttccgaat gtcacgcttg tcggagtgtt aagtgctgat acaacacttc 1519801 atattcctga tttcagatcg gctgaaaaaa catttcagct gttaacgcaa gtcagcggcc 1519861 gggcaggcag gcatgaaaag cccggccatg tcatcattca aacgtataca ccgtctcatt 1519921 acagtatcca gctgacgaaa acacacgatt atgaaacgtt ctatcagcat gaaatggcgc 1519981 acaggagaga gcaatcctat ccgccatact actatttggc tcttgtgact gtttctcatg 1520041 aggaagtggc gaaagcagcg gttacagctg aaaaaatcgc tcattttttg aaagcaaact 1520101 gcggagctga cacgaaaatt ctcggaccaa gcgcgtcgcc gatagccagg atcaaagata 1520161 gatatcgcta tcaatgcgtg ataaaataca aacaggaaac ccagttatcc gctttattga 1520221 agaagatact ggaacattat aaacgcgaaa ttgaacaaaa acatgtaatg atttcaattg 1520281 atatgaatcc ttatatgatg atgtaagatc tcacgtcttg gagggtaaca aattggcagt 1520341 aaaaaaggtc gtcacacatc ctgcggaggt tttggaaaca cctgcggaaa ccgtgactgt 1520401 ttttgataaa aagctaaaaa aactgcttga tgatatgtac gacaccatgc ttgaaatgga 1520461 tggtgtcgga ctggcagcgc cgcaaatcgg cattttaaaa agagcggccg tcgtagaaat 1520521 cggggatgac agagggagaa ttgatctcgt taatcctgaa attttagaaa aaagcggcga 1520581 gcaaaccgga attgaaggat gcttgagctt tcctaacgtc tatggtgatg tcacacgtgc 1520641 cgattatgtc aaagtgcgtg cgtttaaccg tcagggaaaa ccgttcattc tggaagcgcg 1520701 aggcttttta gcaagagccg tgcagcatga aatggaccac ttagacggtg tgctgtttac 1520761 atctaaaata agtaaatact atacagaaga tgaactagcg gatatggaag gatgatttga 1520821 tgacgagaat cgtatttatg ggaacgccgg atttttcagt tcctgtttta agaaccctga 1520881 tagaggacgg atatgaagta gtgggggtcg tcacacagcc ggaccgtccg aagggcagaa 1520941 aaaaagtact gacacctcct ccggtaaagg aagaggcatt gcgccacggc atcccggttc 1521001 ttcagccgga aaaagtcaga ttgacagaag aaattgaaaa agtgctggca ttaaagcctg 1521061 acctgattgt aacggcggca ttcggacaaa ttttgcctaa agagcttctc gacagtccaa 1521121 aatacggctg cattaacgtt cacgcatccc ttttgccgga actgcgcggc ggtgctccga 1521181 tccattattc cattctgcag ggaaagaaga aaaccgggat taccattatg tatatggtag 1521241 aaaaattgga tgcgggcgat atgatctcaa aagtggaagt ggacattgaa gaaaccgaca 1521301 atgtcggaac actgcacgat aaattaagcg ttgctggcgc gaagctattg tctgaaacgg 1521361 ttccaaacgt tattgccggc agcatatcac ctgaaaagca ggatgaagag aaagcgacgt 1521421 acgcgcctaa cattaaaaga gagcaagagc tgctcgactg gtccagaacg ggcgaagagc 1521481 tttacaacca gatccgcggc ttaaatccat ggcctgttgc ttatacgact ctaaacggac 1521541 aaaacttgaa aatatgggcg tcgaaaaaaa tagcggcacc aacaacagct gagcccggca 1521601 cagtcgttgc agttgaaaag gaaggaatta tcgttgccac aggtaacgag acggctctgt 1521661 tattaaccga actccagccg gcaggcaaaa aacgaatgaa aggcgaagac tttgtgcgag 1521721 gcgctcatgt tgaagccggt gatgtgttag gagtaaacaa tgaaaaaaac tagtgttcgt 1521781 gacatcgccc ttgaggcgct gatcaaatta gaacaaaacc aggcatacag caacctgctg 1521841 ctgaaatcgg tcattaaatc aaatgaactg agtgatcaga acagagggct tttgactgaa 1521901 cttgtctatg gtacattaca aaataagatc gcgcttgatt atatgcttaa accgtttatc 1521961 aataagcctc aaaaggtaaa gccgtgggtg attcagcttc ttcgcctatc cttatatcaa 1522021 atggagtatt tggagaagat tccagacagg gcagccattc atgaagcggt tgagattgct 1522081 aaaatccgcg gacacaaagg cattgcttca tttgtcaacg gcgtgctccg ttctattcag 1522141 cgcgaaggtg ttccatcctt tgacgcgatc gaagatcctg tccgccggct ggcgacagaa 1522201 acaagccatc cggaatggct tgtgaaagag tgggcggatg cgtatggatt tgaagctgcg 1522261 gaaaagattt gccgcatcca tctcattccg ccgaaacaga cgctgcgtgt caatcaaatg 1522321 aaagcagaca gagctgagct gcttgaccaa atggctgctg agggaatcga agttgaaaaa 1522381 ggcgacctcg ctgaagatgc tgtgaagctc ttaaagggaa caattgccgg aactcatttc 1522441 ttccaaaacg gcgaagtttc tatccaggat gagagctcca tgctcgtcgc ccgcgccctt 1522501 gatcctaagt cagatgaaac agtgcttgac gcgtgtgcgg cgcctggcgg aaagtcggct 1522561 catatcgcag aattaatgaa gaacaagggg agcgttacgt cgcttgatct tcacaaacat 1522621 aaagtgaagc tgatcaaaga agcggcagat cggcttggcc tgacaatcat tcatgcggaa 1522681 acaatggatg ctagaaaagc gggggaaacg tttgaaaacg aacagtttga ccgaatattg 1522741 gtcgatgccc cgtgctcagg tttcggtgtt atcagaagaa agccggacat gaaatacacg 1522801 aaaaaacctg acgacagcgc ccgtctagct gaaatccagc tgtcgatctt gagggaaatc 1522861 gcaccattag taaaaaaagg tggcactctt gtctacagta cgtgtacaat ggaccggaca 1522921 gaaaatgatg aagtaataca tgcgtttata caagaacatc ctgattttga acccgatttg 1522981 tctcttgaaa agcggctgcc tgaaaaggtg agaccctttg ttcgggatgg aaggcttcaa 1523041 atccttcctc attatttcgg aacagatggt ttctttattt gcagcatgag aaagaaggga 1523101 taagcaatgg cagaacttaa taaaacaaaa gtaagaaaag aattgcggac agagcgtccg 1523161 tctatttatt cttttgaatt agatgaaatc aaacaatggc tgacagacaa tggagagaaa 1523221 ccgttccgtg cagcccagat ctttgaatgg ctatatgaaa aacgcgtatc ttcttttgaa 1523281 gatatgacaa acctctcaaa ggatctgcgt gagaaattaa acactcgctt tgtgttaaca 1523341 acgctgaaaa cggctgttaa acaaacctct caagacggta cgatgaagtt tttgtttgag 1523401 cttcatgacg gttataccat cgaaaccgtt ttaatgagac acgagtatgg caattctgta 1523461 tgtgtaacga cacaagtcgg ctgccgtatt ggctgcacat tctgcgcgtc aacgcttgga 1523521 ggcttaaaac gaaaccttga agcaggggaa attgtcgctc aagtagtcaa agtgcaaaaa 1523581 gctcttgatg aaacggatga acgcgtcagc tctgtcgtga tcatgggaat cggcgaacct 1523641 tttgataact ttaacgaaat gctcgctttc ttgaaaatca ttaaccatga caagggcctg 1523701 aatatcggtg ctcgccatat tacggtctct acgagtggaa tcatcccgaa aatttacgaa 1523761 tttgctgatc agcaaatgca gattaacttt gcaatttctc tgcacgcgcc gaacacagaa 1523821 atcagaagcc gtttgatgcc gattaacaga gcatataaac tgcctgatct aatggaagcc 1523881 gttaaatatt atattaataa aacaggacgc cgtatcagct ttgaatacgg gctgttcgga 1523941 ggcgtaaacg accaggtgga acacgccgaa gagcttgccg acttgctgga aggagtcaaa 1524001 tgccacgtga acttgattcc ggtaaactac gtgcctgaac gggactatgt gcgcacaccg 1524061 cgtgatcaga tttttgcttt tgaaaaaacg ctgaaatccc gcggagtaaa tgtcacaatc 1524121 cgaagagagc aaggacatga cattgacgca gcctgcggtc agcttcgcgc gaaggagcgt 1524181 caagacgaga cgaggtgatg agggttgtta acagccttaa aaacagatac aggaaaaatc 1524241 cgccagcata atgaagatga tgcggggata ttcaagggga aagatgaatt tatattagcg 1524301 gttgtcgctg atggcatggg cggccatctt gctggagatg ttgcgagcaa gatggctgtg 1524361 aaagccatgg gggagaaatg gaatgaagca gagacgattc caactgcgcc ctcggaatgt 1524421 gaaaaatggc tcattgaaca gattctatcg gtaaacagca aaatatacga tcacgctcaa 1524481 gcccacgaag aatgccaagg catggggacg acgattgtat gtgcactttt tacggggaaa 1524541 acggtttctg ttgcccatat cggagacagc agatgctatt tgcttcagga cgatgatttc 1524601 gttcaagtga cagaagacca ttcgcttgta aatgaactgg ttcgcactgg agagatttcc 1524661 agagaagacg ctgaacatca tccgcgaaaa aatgtgttga cgaaggcgct tggaacagac 1524721 cagttagtca gtattgacac ccgttccttt gatatagaac ccggagacaa actgcttcta 1524781 tgttctgacg gactgacaaa taaagtggaa ggcactgagt taaaagacat cctgcaaagc 1524841 gattcagctc ctcaggaaaa agtaaacctg cttgtggaca aagccaatca gaatggcgga 1524901 gaagacaaca ttacagcagt tttgcttgag cttgctttac aagttgaaga gggtgaagat 1524961 cagtgctaat cggcaagcgg atcagcgggc gttaccaaat tctccgcgtc ataggcggcg 1525021 ggggaatggc caacgtgtat ttagctgagg atatcattct agaccgtgaa gtcgcaatta 1525081 aaatcctgcg gtttgactat gcaaatgaca atgaatttat cagacgtttc cgcagagaag 1525141 cccaatccgc atcaagcctc gatcacccga atattgtcag catttatgat ttgggcgagg 1525201 aagatgatat ttattatatt gtcatggaat acgttgaagg catgacgctt aaagaataca 1525261 taacagcaaa tgggccgctt caccctaaag aagcgctgaa catcatggag caaattgtct 1525321 cagccatcgc tcatgcccat caaaaccaga ttgttcacag agacatcaag ccgcataaca 1525381 ttttgattga tcatatggga aatatcaaag taacggattt tggaattgcg acggcactaa 1525441 gttcgaccac aatcacccat accaattcag ttctgggctc ggtccattac ttatcacctg 1525501 aacaggcccg gggcggctta gccacaaaaa aatcggatat ttatgcgctt ggaatcgttc 1525561 tatttgagct tttaaccggc cgtattccgt ttgatggaga gtcagcagtc agcatcgcct 1525621 tgaagcatct tcaagcggaa actccttcgg caaaaaggtg gaatccatcg gtcccccaaa 1525681 gcgttgaaaa catcatactc aaggcaactg ccaaagatcc ttttcatcgc tacgaaacgg 1525741 ctgaagacat ggaagcagac ataaaaacag cttttgatgc cgacagactc aatgaaaaga 1525801 gatttacgat tcaagaagat gaagaaatga caaaagcgat acctatcatt aaagatgaag 1525861 aacttgctaa agctgctggc gaaaaagaag ctgaagtgac aaccgcacaa gaaaacaaaa 1525921 caaagaagaa cggcaaaaga aaaaagtggc cgtgggtttt gctcacgata tgcctcgttt 1525981 ttatcacagc tggaattctt gctgtcactg tttttccgtc gcttttcatg cctaaggatg 1526041 tcaaaatacc tgatgtctcc ggaatggaat acgaaaaagc cgcagggctc ttggaaaaag 1526101 aaggtttaca ggttgattcc gaggtgttgg aaatctcaga tgaaaaaatt gaagagggcc 1526161 tgatggtaaa aacggatcct aaagcggata ccacagtcaa agaaggcgcc acggtcaccc 1526221 tttataagag caccggaaaa gcaaaaacgg agatcggtga tgtgacaggc caaacggtcg 1526281 accaagcaaa aaaagcgttg aaggaccaag ggtttaatca tgtaacagta aatgaagtga 1526341 atgacgagaa aaatgcgggc actgtcattg accaaaatcc ttcagcaggg actgagctgg 1526401 tcccgagtga agatcaagtc aaacttacag tcagtatcgg acccgaagac attacgctta 1526461 gagacttgaa aacctacagt aaagaagcag cgtctggata tctggaagac aacggattga 1526521 agcttgtaga aaaagaagca tactcagatg atgttccaga aggacaggtt gtcaaacaaa 1526581 aaccagcagc aggtacggca gtaaagccgg gaaacgaagt tgaagtgaca ttctctctcg 1526641 gaccagagaa aaaacctgcg aaaacagtga aagaaaaggt caagatcccc tacgaaccag 1526701 aaaatgaagg ggacgagctt caagtgcaaa tcgcggttga cgatgcggat cacagcatct 1526761 ctgacactta cgaagaattt aagataaaag agccgactga acgaacgatc gaactaaaga 1526821 ttgaaccagg ccaaaaaggg tactatcaag taatggtaaa caataaagtt gtcagctaca 1526881 aaaccattga gtatccgaaa gatgaataac aaggagggaa aatatgcctg agggcaaaat 1526941 tattaaggcg ctaagcggct tttactatgt actggatgaa tcagaggatt cagataaagt 1527001 aatacaatgc agaggaagag gcattttcag aaaaaacaaa attacccctc ttgtcggtga 1527061 ttacgttgtg tatcaagctg aaaatgacaa agaaggatat ctaatggaaa ttaaagaaag 1527121 aaccaacgag cttatcaggc cgccaatttg caacgttgat caagcggtcc ttgttttctc 1527181 agcggttcag ccttctttca gcacggcatt gctcgaccgc ttcctggttc tcgttgaggc 1527241 caatgatatt cagccgatta tatgcattac taaaatggat ctgattgaag atcaagatac 1527301 agaagatacg atacaagcct atgcagaaga ctatcggaat attggttatg acgtatacct 1527361 tacctcctct aaggaccaag atagtttagc ggacatcatc ccgcattttc aggataaaac 1527421 aacggtattt gccggtcagt ccggtgttgg gaaatcctcg cttctcaacg cgatcagtcc 1527481 ggagctcgga ttaagaacaa acgagatttc cgagcatttg ggccgcggga aacacacaac 1527541 ccgccacgtg gagctgattc acacgtccgg aggtttggtt gcagatacac cgggattcag 1527601 ctcgcttgaa tttacagaca ttgaggaaga agagctgggc tataccttcc ctgatatcag 1527661 agaaaaaagc tcttcatgca aatttagagg ctgtttacat ctgaaagagc cgaaatgtgc 1527721 ggtgaaacaa gctgttgaag acggggaatt aaagcagtat cgctatgacc attatgttga 1527781 atttatgacg gagattaaag acagaaagcc gaggtattag cataatgata aaggttgcac 1527841 catctattct ttccgctgat tttgccgctt taggcaatga gattaaagat gtagaaaaag 1527901 gcggagccga ttgtattcat attgatgtta tggacggcca ttttgtcccg aatatcacaa 1527961 tcggtccgct gattgtagaa gcggtccggc cggtaacgga tctgccgctt gatgtccatt 1528021 taatgataga agagccggat cgttatatcc cggcttttgc gaaagcaggc gcagatatcc 1528081 tgtctgtgca tgctgaggca tgtccgcacc tgcaccgtac catccagctc attaaagagc 1528141 aaggagtgaa ggccggagta gttctaaacc cgcatacccc tgtacaagtc atcgaacatg 1528201 ttttcgacga tcttgatctt gttcttttaa tgacggtgaa cccgggcttc ggcgggcaga 1528261 aatttattca ttcagtcctt cctaaaataa aagaggttaa gcgaatggcg gatgaaaaag 1528321 gaaaaaaaga tctgttaatt gaagtagacg gcggcgtcaa caaagaaacc gctccgctcg 1528381 tcattgaagc gggcgcaaat ttactcgttg ccggttcagc tgtttatggc cagtctgacc 1528441 gcaaaaaagc aatttctgaa atcagaggaa gtaaataagc agctttagaa aagagctggg 1528501 catacaatag cctaagctct ttttcctgta tgcagagaaa ggaatcagag atgaaaacaa 1528561 ttaatatcgt tgcgggaggc ccgaaaaatc tcattcccga tctaaccggc tatacggatg 1528621 aacacacgct ttggatcggt gttgacaaag gcaccgtcac tctcttagat gccgggatca 1528681 ttcctgttga agccttcgga gattttgaca gcataacgga gcaagaacgc cggcgaatag 1528741 aaaaagccgc tcccgccctt catgtgtatc aagcagaaaa agatcaaaca gatttagacc 1528801 tcgcccttga ttgggcgctg gaaaagcagc cggatattat tcagattttc ggcattacag 1528861 gcggcagagc tgatcatttt ttaggaaaca ttcagcttct gtataaaggt gtaaaaacga 1528921 acataaaaat taggctgata gacaaacaaa atcatattca aatgttccct cctggtgaat 1528981 atgatattga gaaggatgaa aataagcgat atatctcctt cataccgttt tccgaagaca 1529041 tacatgagct gaccctgacc ggttttaaat atcctctaaa taattgtcat attacgctcg 1529101 gttcaacact atgtattagt aacgaactca ttcattcacg aggtactttt tcgtttgcaa 1529161 aaggcatatt aataatgata agaagcacgg attaagcatg tgctttcatt caattgctga 1529221 aaacaatgaa caaggcggtt acgggacgtt ataggagggg acaaaaatga aattttacac 1529281 cattaaattg ccgaagtttt taggaggaat tgtccgggcg atgctgggct catttagaaa 1529341 agattaatgc ccaggggttc aaagccctct ttcaccacat aaaaacgcct gccacatatc 1529401 ggggcaggcg ttcattttgt tatacacgct caactttacc ggatttcaaa gctcgagcag 1529461 atacatatac ttttttaggt tttccgttca caaggatacg aaccttttga agattcgcgc 1529521 cccaagtgcg cttagaagcg ttcattgcgt gagaacggtt attcccagct gttgtttttt 1529581 tacctgtgat aacgcattta cgtgccattt gtttccctcc tcacttgcac aaaacatcta 1529641 ctttttaaca ttcatataat cttagatgct ttcgatatgg atactttaaa taatttacca 1529701 cagctaaaaa acgtttgcaa ctattgtttc atcatctttc aagaaaattc acttgacatc 1529761 ttgcggaaac agcagcgcta tagtatatgt agaggtacgg ccagcgatta ttgcctggtc 1529821 ttttcataat ggaaaccata tagtagaata gctgtaactc tatgcattcg aaggaggaac 1529881 tagtgtgtcc attgaattaa gaacgaagta cggacagatt gatatatcta atgaagtcat 1529941 cgcgatggtt gcaggaggcg cggcggttga ctgttacggc attgtcggca tggcctctaa 1530001 aaaccagatt aaagacggac tgactgaaat ccttcggaaa gagaatttca gcaggggtgt 1530061 ccaagttcgc caagaaggag aacagataca tatcgacatg tatatcattg tcagctacgg 1530121 cacgaaaatt tctgaagtgg cacataatgt ccaaacaaaa gtaaagtaca cagtaaatca 1530181 aaccatcgga ctggcagtgg attctgtcaa tatttatgtc caaggcgtac gagtgacgaa 1530241 cccgtagtta ggaggagtag gattgtctat cagaacatta gacggcagaa cctttgccga 1530301 gatgattctt gcgggagcgc agaatctgtc tcaaaacgcc agtgcagttg atgcactgaa 1530361 cgtgttcccg gtgccggacg gtgatacggg aacaaatatg aacctgtcga tgacttccgg 1530421 agcaagagaa gttgaacaaa tggatacgga tgatatcggg aaggtgggct ccgcgttatc 1530481 taaagggctg ctcatgggag cacgcggaaa ttcaggagtt atcctatccc aattgttccg 1530541 cggatttagc aaaaacattg aaacgaaaaa agaaattaat gcacttgagt ttgccgctgc 1530601 gctgcaagca ggtgtagaca tggcgtataa agctgtcatg aaacctgtag agggcaccat 1530661 tttaacagtt gcaaaagacg ctgcaaaaaa agcaatgatc ttagcagaaa aagaaaccga 1530721 tatcactgcg ctgatgactg cagtgacaga agaagcagag gcgtctttaa accgcacccc 1530781 tgaattgcta cctgtcctaa aggaagtagg agttgtcgat agcgggggca aaggcctgct 1530841 ctgtgtgtat gaaggtttcc ttgcttcatt aaaaggtgaa actgtacctc agaaagcagt 1530901 tcttccgtca cttgacgaca tggtcagcgc agagcatcac aagagcgcgc aaagcatgat 1530961 gaataccgaa gatattgaat ttggattctg taccgaagtg atggttaggc ttgatcagac 1531021 aaaaagagag ttcgacgaag gcacgttcag gcaagacctc agccagttcg gagattctct 1531081 gcttgtgatt gcggatgaat cgctggcgaa ggttcatatt catgctgaag agccgggaaa 1531141 cgtgttaaac tacgcccagc attacggtga attgatcaaa ataaaaatag aaaatatgag 1531201 agaacagcat acctctatca tcagtcaaga aagcaaacct gcagacaacg aaacaccgcc 1531261 ggcaaaacag ccgtatggca ttgtgactgt agcgatggga gaaggaattg cagacctatt 1531321 taaaagcatt ggcgcttctg ttgtgattga aggcggccag accatgaacc caagcactga 1531381 ggatattgtt gatgccgtga agtctgtaaa tgcagatacg gtatttatcc tgcctaacaa 1531441 ctccaacatt atcatggctg ctaaccaagc ggccagcgta gtggatgaac aggtttttgt 1531501 cattcctgct aaaacggttc cgcaagggat gtcagctctg ctggctttta acccggatca 1531561 agaagctgaa gcgaacgagg ccaatatgct aagcgccatt cagcaagtaa aaagcggaca 1531621 ggtgacgttc tcagtcagag atactcatat tgacggtaaa gacattaaaa aaggcgactt 1531681 tatgggcatt ctgaatggaa cgattatcgg cacttctgaa aatcagctgt cagccgcgaa 1531741 aatgctgctg tcagaaatga tcggagaaga tgatgaaatc gtgaccattc tatatggtga 1531801 ggatgcgtct caggaagaag ctgagcagct tgaagcgttt ctcagtgaaa agtacgagga 1531861 gattgaggtt gagatccaca atgggaaaca gcctctgtat tcgtatatag tttcagcaga 1531921 atagaagggc aatttgccct tctattctta tgtctgcttt taagtgcggc agcgctgtaa 1531981 cgcgcccgct tgccatttta tatctgatca attagtctag aagcaaagcg ctaataagct 1532041 ctggttcata aggaggaata gcatgaaata cagaagcgtt tttgatatta tcggcccggt 1532101 tatgatcggt ccgtccagct ctcatacagc gggagctgct agaatcggga gagtggccag 1532161 aagtttattt ggcagagagc ctgagcgcat cattgtatct ttttacggct cgtttgcgga 1532221 aacgtataag ggccacggca cagatgtcgc gattatcggc ggattgcttg attttgatac 1532281 attcgatgaa cggattaaaa ccgctataca aattgcagaa gctaaaggaa ttgatataga 1532341 gtttcgggta gaagacgcag tcccggtcca cccgaacaca gcaaaaatca ccatttctga 1532401 tgaaaagggt gagctggaac tgacgggtat ttcgattggc ggaggaaaga ttgaaatcac 1532461 agaattgaat ggttttgagc tccggctgtc aggaaatcat ccggccatat tagttgttca 1532521 taatgacaag tttggcacaa ttgccggtgt tgccaatgtt ctggcgaaat tttcaatcaa 1532581 cgtaggacat atggaagtag cccggaaaga tatcggccag cttgcgctga tgacaataga 1532641 ggtcgatcaa aatattgacg accacattct cgacgagctg tcgaagctgc cgaatattat 1532701 tcaagtgaca aagattgctg actagcgaaa agggtcagga ggagccagtt atgtttcgta 1532761 atgtaaaaga attaattgag attactaaag aaaaacaaat attgatctct gatgtgatga 1532821 tagctcaaga gatggaagta acagaaaaaa caaaagagga catttttcag cagatggatc 1532881 ataacctgtc tgttatggaa gcggcggttc agaaaggact cgagggagtt acgagccaaa 1532941 cgggcttaac aggcggagat gccgttaaat tgcaggccta tattcgatca ggaaaaagcc 1533001 tgtctggccc gctgatttta gatgctgtat cgaaagccgt tgcaacaaat gaagtaaatg 1533061 cagccatggg aaccatctgt gcgacaccga ctgcaggttc tgccggtgtg gtgcccggta 1533121 cgttatttgc tgtaaaagaa aagctgaatc caacaagaga acaaatgatc cgctttttgt 1533181 ttacagccgg ggctttcgga tttgtcgtgg ccaataacgc aagcatttcc ggcgccgccg 1533241 gaggatgtca ggcagaggtt ggatcagctt caggcatggc ggctgcggct attgttgaaa 1533301 tggcaggagg aacacccgaa caaagcgcgg aagccatggc cattacatta aaaaatatgc 1533361 taggcctcgt gtgcgaccct gttgcagggc ttgttgaggt gccttgcgtg aaacggaatg 1533421 cgatgggcgc gtcaaatgcg atgattgctg ctgatatggc attggcgggc attacaagcc 1533481 gtattccatg tgatgaggtt atcgatgcca tgtataaaat aggccaaacg atgccaactg 1533541 cacttagaga aacaggccag ggcggtttag cggcaacacc gacaggaaga gaattagaga 1533601 aaaaaatttt cggaggagcg ctaggttcac gtgaaacaac atcagcaaac tagtatagct 1533661 aacattaagg gtattgggcc ggaaacagaa aaaacattga atgaactcgg tatttatgac 1533721 atttctgatc ttctgaatta tttcccttat cgctatgatg actacgagct gagggattta 1533781 gaagaagtaa agcatgatga aagagtcaca gtcgaaggga aggttcattc agagccttct 1533841 cttacctatt acggaaaaaa acgaaacagg ctgacattca ggcttctggt cggccactat 1533901 ttaatcacag ccgtatgttt taaccggcct tatttgaaga agaagctttc gctcggctct 1533961 gtggtgacgg tttcaggtaa atgggacaag caccgccaaa ccatctctgt tcaggagttg 1534021 aaaaacgggc cgcatcaaga agacaaaagc attgaaccag tgtattctgt gaaagaaaat 1534081 gttaccgtca aaatgatgag gcgctttatt cagcaggcgc tgacccaata tgcagactca 1534141 cttcctgatc ctcttccgga aaagctaaga aaaagctata aactgcctga ctattatcaa 1534201 gcgttaaaag caatgcacca gcctgaaaca agggaagcat taaagcttgc cagacggcgg 1534261 tttgtttatg aagaattttt gttgtttcag ttgaaaatgc aggcgttccg aaaggcggaa 1534321 agagagcaga cacaagggat acggcagcgt ttttcaaacg aagaactcat gagatttatc 1534381 aaaagcctcc cgtttcccct cacaaacgcc cagtcacgcg ttcttcgcga aataacagca 1534441 gacatgtctt ctccatacag aatgaaccgt cttcttcaag gggacgttgg atcaggaaaa 1534501 acggcagtcg ccgccattgc actgtatgcc gcgatcctat ccggatacca aggagcgctc 1534561 atggtgccga cagaaattct ggccgagcag catgctgatt cgctcgtttc gctatttgaa 1534621 aaatgggacg tcagcgttgc tcttttgaca agctctgtta aaggaaagcg gcgaaaagaa 1534681 ctgcttgagc gtcttgcggc gggtgagatt gatattcttg taggaaccca tgctttaatc 1534741 caagacgagg tggagtttaa ggcgttgagt ctcgttatta ctgatgaaca gcacagattt 1534801 ggagttgagc agcgcaaaaa gcttcggaac aaagggcagg atcccgatgt tctctttatg 1534861 acagccactc caatcccaag aacattagcg atcacagtat tcggtgaaat ggatgtatct 1534921 gtcattgatg agatgccggc tggacgaaag cgaattgaaa cctattgggt aaaacatgac 1534981 atgcttgatc gtattttggc atttgtcgaa aaagaattaa agcaaggcag gcaggcttat 1535041 atcatctgtc cgctgattga agaatcagat aagcttgatg tgcaaaacgc cattgacgtg 1535101 tacaatatgc tttctgatat ttttcgggga aaatggaatg tcggccttat gcatggaaag 1535161 ctgcattccg atgaaaaaga tcaggtcatg agagaattca gcgcaaatca ctgtcaaatt 1535221 ctcgtatcaa ccactgttgt ggaggttggc gtaaatgttc cgaatgcaac aattatggtg 1535281 atttatgacg ccgaccgttt cggactatca cagcttcacc agctgcgcgg ccgtgttgga 1535341 cggggtgagc atcaatcttt ctgtattctg atggctgatc caaaatcaga aacagggaaa 1535401 gaacggatga ggatcatgtc ggagaccaat gacggtttcg agctgtctga aaaggatctg 1535461 gaactgagag gtcccggtga tttcttcggg aaaaaacaaa gcggaatgcc ggaatttaaa 1535521 gtggcggaca tggttcatga ttacagagcg cttgaaacgg caaggcagga tgctgcgaat 1535581 cttgtggctt ctgacgcgtt ctggaaggag ccggaatacg ctgtgttaag agatgaattg 1535641 ctgaagagcg gagtaatgga cggggaaaaa ttaagctgag tatcagaagt ttttggtgtt 1535701 cagccagaaa caatcgttgc attccaatct atgaaattat atactactat tagtacctag 1535761 tcttaattgt ccggatggtg tttagatatg agaagaaata agagagaacg ccaggaatta 1535821 cttcagcaga cgattcaagc aacccccttt attacagatg aagaactagc gggtaaattc 1535881 ggggtgagca tccagacgat acgtttggac cgcttagagc tttccatacc tgaactgaga 1535941 gaaagaatta agaacgtggc agagaaaaca cttgaggacg aagtgaagtc cctgtcactt 1536001 gatgaagtta tcggagaaat tattgacctt gagctggatg atcaggcgat atccatttta 1536061 gaaataaaac aggagcacgt gttcagccgg aatcagattg cgagaggaca ccatttattt 1536121 gcacaggcga attctttggc cgttgcagtc attgatgacg agctggcgct gactgcaagt 1536181 gcagacatcc gctttacaag acaggtaaag cagggtgaac gtgtcgtagc aaaagcgaaa 1536241 gtgacggctg tcgaaaaaga aaaaggaaga acggttgtcg aagtgaacag ctacgttggc 1536301 gaagaaattg ttttttctgg acgctttgac atgtatcgtt caaaacattc ataaaggtgg 1536361 agcatgcatg agaatagctg tagatgcaat gggaggagac cacgctccca aagctgttat 1536421 tgacggagtt ataaaaggta tagaggcatt tgatgatctc catatcacac ttgtcggtga 1536481 caaaacaacg atagaatcac atttaacaac tacatcagat cgcatcacgg tgctgcacgc 1536541 agatgaagtg attgagccta cggatgaacc ggtccgtgcc gtgcgaagaa aaaagaactc 1536601 atctatggtt cttatggcgc aggaggttgc ggaaaacaga gctgacgcct gcatttcagc 1536661 gggaaatacc ggtgcattaa tgacagccgg tctctttatt gtcgggagaa ttaaaggaat 1536721 tgaccgtccg gcgcttgctc cgacacttcc gactgtttcg ggagacggat ttcttctcct 1536781 tgatgtcggc gccaatgtcg atgccaaacc ggagcacctc gttcaatatg ccatcatggg 1536841 ttctgtttat tctcagcaag tgcgcggtgt cacttcaccg agagtcggac ttttaaatgt 1536901 cggaacagaa gataaaaaag gaaacgaact gacgaagcag acgtttcaaa ttttaaaaga 1536961 aacagcaaac atcaatttta tcggaaacgt ggaagcgcga gaccttttag atgatgtggc 1537021 ggatgttgta gtaacagacg gctttaccgg gaatgttaca ctcaaaacgc tggaaggctc 1537081 tgcgttgtca atttttaaaa tgatgagaga cgtaatgacg tctactttga catccaagct 1537141 tgcagcagct gtgctgaaac caaaattgaa agaaatgaaa atgaaaatgg agtattcgaa 1537201 ttatggcgga gcaagtcttt ttggcttaaa agcgcctgtg atcaaggcgc acggctcttc 1537261 agattcaaat gctgtattcc atgcgattcg gcaagcaaga gagatggtca gccaaaatgt 1537321 ggctgcgctc attcaggaag aagtgaaaga agaaaaaaca gatgagtagt ctggaggttt 1537381 ttacatcatg agtaagattg catttttatt cccgggtcag ggatcacaat ttatcggcat 1537441 gggaaaagag ctttatgagc aggtgcctgc tgcaaagcgt ctgtttgatg aagccgatga 1537501 aacgttggaa acaaaactca gctcgcttat ttttgagggg gatgctgaag aattaacact 1537561 tacatacaat gcgcagcctg ctttgcttac gacaagcatc gctgttcttg agaaatttaa 1537621 agaatctggc attacacctg atttcacagc aggacacagc cttggtgaat attctgcact 1537681 ggttgcggct ggcgctctgt ctttcaaaga tgctgtttat actgtcagaa agcgcggaga 1537741 gtttatgaat gaagcggtgc cggctggcga aggagcaatg gctgcgattc tcggcatgga 1537801 tgctgaagca ttaaagcaag taaccgataa agtcacagag gaaggcaacc ttgtacagct 1537861 tgcgaatctc aactgtcctg gccaaatcgt catttccgga acagctaaag gggttgagct 1537921 tgcatctgaa ctggcaaaag agaacggcgc aaaacgcgca attccgcttg aagtaagcgg 1537981 tccgttccat tctgaactga tgaaaccggc tgctgaaaag ctgaaagagg tattggacgc 1538041 ctgtgacata aaagacgctg acgttccggt catctcaaat gtttctgctg acgtgatgac 1538101 tgaaaaagca gatatcaaag aaaaacttat tgagcagctt tactctccgg ttcgttttga 1538161 ggaaagcatt aacaagctga tcgcagaggg tgttacgact tttattgaaa tcggtcccgg 1538221 aaaagtgctt tcaggccttg tgaaaaaagt gaatagacgg ttaaaaacaa ttgctgtatc 1538281 agatccggaa acgatcgagc tggcaattca aacgcttaag gaggagaatg ataatgctta 1538341 atgataaaac ggctattgtc actggcgcat cccgcggaat cggccgctca atcgcccttg 1538401 atctggcaaa aagcggagca aatgttgtcg tgaactactc cggcaatgaa gcgaaagcaa 1538461 atgaagtggt agatgaaatc aaatcaatgg gcagaaaagc aattgctgta aaagcggatg 1538521 tatcaaatcc cgaagatgta caaaacatga taaaagaaac attgtctgtt ttttctacga 1538581 ttgacattct ggttaataat gcgggaatta caagagacaa tctcatcatg agaatgaaag 1538641 aagacgaatg ggatgacgtc attaacatta acctgaaggg tgttttcaac tgcacaaaag 1538701 ctgttacaag acaaatgatg aaacagcgtt caggccgcat tattaacgta tcgtctatcg 1538761 tcggcgtcag cggaaaccct ggacaagcca actacgtggc tgcaaaagcc ggcgtcatcg 1538821 gtttaaccaa atcttctgct aaagagctcg ccagccgaaa tattacggta aacgcaatag 1538881 cgccaggatt tatctcaact gatatgacag ataaacttgc aaaagacgtt caagacgaaa 1538941 tgctgaaaca aattccgctc gcgcgctttg gtgaacctag cgatgtcagc agtgttgtca 1539001 cgttcctagc ttcagaggga gctcgttata tgacaggcca aacgcttcat attgacggcg 1539061 gaatggtgat gtaagttttt tctcgaaaat ttcatcgtag tttctctagt tttttaaaaa 1539121 cgaatccact ataatacttg aggggaggtg aattgctatg gcagacacat tagagcgtgt 1539181 aacgaaaatc atcgtagatc gccttggcgt tgatgaagca gacgtcaaac ttgaagcttc 1539241 tttcaaggaa gacttaggtg ctgattccct agatgtagtt gagcttgtta tggaacttga 1539301 agacgagttt gatatggaga tttctgacga agatgctgaa aagattgcaa cagtcggcga 1539361 cgctgtgaac tacatacaaa accagcaata agctgatgct aaaagtcccg ccgaaacgcg 1539421 gggctttagc cctttattcg tgcagttatt acagcatgcc gcttttacgc gcgctgtatc 1539481 cggtttagtc agagaagcgc ggtgaacctg atgtgcctat ggaggttact atgtcaaaac 1539541 actcacatta taaagataaa aaaaagttct ataaaaaagt agaacaattt aaagagtttc 1539601 aagaacggat ttcggttcac tttcaaaatg aaaagctttt gtatcaagca tttacacatt 1539661 catcttatgt gaatgagcat cggaaaaagc cgtatgaaga taatgaaagg cttgaatttt 1539721 taggtgacgc tgttttggaa ctgacgatct ccagattctt atttgccaaa tacccggcta 1539781 tgagtgaagg agatttgacg aaattgagag ccgcaattgt ttgcgaaccg tctctcgttt 1539841 cattggctca cgagctgtca ttcggcgatc ttgtcctgtt gggtaaaggc gaggaaatga 1539901 caggcggaag aaagcgtcct gctctattgg cggatgtttt tgaggcattt atcggagcct 1539961 tgtaccttga ccaaggatta gagccggtcg aaagtttctt aaaagtttat gtgttcccta 1540021 aaattaacga tggtgctttt tctcatgtga tggatttcaa aagccagctg caggaatacg 1540081 tgcagcggga cggcaaaggc tctctggagt ataaaatctc caacgaaaaa ggacctgcgc 1540141 acaaccgtga atttgaagcc atcgtatctc taaaaggtga accactcgga gtcggaaacg 1540201 gccgttcaaa gaaagaagcc gaacagcacg ctgctcagga agctttagct aaattgcaaa 1540261 aacaccatac gaaacaataa aatccccctt atgactcagg gggatttcag tatgtatgcc 1540321 gtcttatttg accaatgttt atgatagaat tgaaatactt attacataag gaggatcgct 1540381 atgttcctca aacgtttaga cgttatagga tttaaatcat ttgcagaacg gatttccgta 1540441 gacttcgtta aaggcgtgac agcagttgtc gggccgaacg gaagcggaaa aagcaacatc 1540501 acggatgcca ttcgctgggt tctcggcgaa caatcggcac gctctcttcg cggcggaaaa 1540561 atggaagaca tcatttttgc tgggagtgat tcaagaaagc gattaaatct agctgaagtt 1540621 acgcttactc ttgataatga tgatcatttc ttgccaattg acttccacga ggtgagtgtc 1540681 acaagacgtg tgtacagatc aggtgagagt gagtttctga ttaacaatca gccatgccgc 1540741 ttgaaagata ttattgattt atttatggac tctgggcttg gtaaagaagc attttctatt 1540801 atcagccaag ggaaagtgga agagatcctg agcagcaaag cggaggatcg ccgcagtatc 1540861 tttgaagaag cggccggggt gcttaaatat aaaacgagaa agaaaaaagc agaaaataaa 1540921 ctgtttgaga cacaggacaa tctaaatcgg gtagaagata tattacatga gcttgaagga 1540981 caggttgaac ctcttaaaat tcaagcttca atagcgaaag actaccttga gaaaaagaaa 1541041 gagctggagc atgttgaaat tgcgctgact gcctatgata tcgaagagct gcatggtaaa 1541101 tggtcgactc ttaaagagaa agtgcagatg gcaaaagaag aagagcttgc tgaatcgtct 1541161 gctatttctg cgaaagaagc aaagattgag gatacaaggg acaaaataca agcgcttgat 1541221 gagtcagtag atgagctcca gcaagtttta ctggtaacta gtgaagagct ggaaaagctt 1541281 gaaggccgta aagaagtcct gaaagaacga aagaaaaacg ctgtgcaaaa ccaagaacag 1541341 cttgaagaag ccatcgttca gttccagcaa aaagaaacgg ttctgaaaga agagctttcg 1541401 aagcaggaag ctgtcttcga aacgcttcag gctgaggtga agcagttaag ggcgcaagta 1541461 aaagaaaaac agcaggctct cagtcttcac aatgaaaatg tcgaagagaa aatcgagcag 1541521 ctgaaaagtg attattttga gctgttaaac agccaggctt cgatacgcaa cgaactccag 1541581 cttcttgatg accagatgtc ccaatccgct gtcacattgc agagacttgc ggacaacaat 1541641 gaaaagcacc tgcaggaacg gcatgatatt tctgcgcgta aagccgcatg tgaaacggaa 1541701 tttgcccgaa ttgagcagga gattcacagt caagtcggtg catatcgtga tatgcagaca 1541761 aaatatgagc agaaaaagcg ccaatacgaa aaaaatgaat ccgctctgta tcaggcatac 1541821 caatacgttc agcaagcgag atcaaaaaag gacatgcttg agacgatgca gggagatttc 1541881 tccggctttt atcaaggtgt taaagaagtg ctgaaagcga aagagcgcct tggcggaatt 1541941 cgcggagcgg ttcttgagct gatttctaca gaacagaagt atgaaacggc cattgaaata 1542001 gcgctcggcg cttctgctca acacgtcgtg accgacgatg aacaatctgc ccgcaaagcg 1542061 attcaatatt taaagcagaa ttccttcggc cgggcgacgt ttctgcctct ttctgttatt 1542121 agagaccgcc agcttcaaag ccgtgacgcg gaaacagccg cccggcattc atcatttctc 1542181 ggggttgcca gtgaacttgt cacatttgat cctgcgtatc gaagcgtcat ccagaatctt 1542241 cttggaaccg ttctgatcac agaggactta aagggtgcaa acgagcttgc gaagcttctc 1542301 gggcaccggt accgcatcgt aacccttgag ggagatgttg tgaaccccgg tggttcaatg 1542361 acgggcggcg cggttaaaaa gaaaaataac tccctccttg gaagaagccg ggagctagaa 1542421 gatgtgacga aacggctcgc tgaaatggaa gagaaaacgg cactgcttga acaagaggtc 1542481 aaaaccctta agcactccat tcaggatatg gagaaaaaac tggctgactt aagagaaacc 1542541 ggggaaggct taaggttaaa gcagcaggat gtgaaaggcc agctgtacga acttcaagtt 1542601 gccgagaaaa atatcaatac ccatttagag ctctatgatc aagaaaaatc tgctctgtca 1542661 gaaagcgatg aagagagaaa agtgcgcaaa cgcaagcttg aagaagagct ctctgccgta 1542721 tctgaaaaga tgaaacagct tgaagaggac atagacagac tgacaaaaca aaaacaaacg 1542781 caatcctcaa cgaaagagtc tctctccaac gagctgactg agctgaagat cgcagcggcc 1542841 aaaaaagagc aggcttgcaa gggggaagag gacaaccttg ccagattaaa gaaagagctc 1542901 actgaaacag agcttgcgtt aaaagaagca aaagaagact taagcttctt aacgtcagag 1542961 atgtcatcta gcaccagcgg cgaagaaaag ctggaagaag cagcaaaaca taaattgaat 1543021 gacaaaacga aaacgatcga actgattgca ttaaggcgcg atcagcgcat caagcttcag 1543081 catgggcttg atacgtatga gcgtgagctg aaagaaatga aacgcctgta taaacaaaaa 1543141 acaacgctct taaaagacga agaagtcaaa cttggacgaa tggaagtcga gcttgataat 1543201 ttactccaat acttacggga ggaatacagc ttgtcctttg agggggcaaa agagaaatat 1543261 cagcttgaaa ctgatccaga ggaagccaga aagcgcgtga agctgattaa actcgcaatt 1543321 gaagagctgg gtaccgtgaa cctcggaagc atagatgagt ttgagagggt caacgaacgg 1543381 tacaagtttc tgtcggaaca aaaagaagat ttaacagaag cgaaaaatac cttgttccaa 1543441 gtgattgaag aaatggatga agaaatgacg aagcgcttta acgacacatt cgtccaaatc 1543501 cgctcacact ttgatcaagt tttccgctcc ttattcggag gagggcgagc tgaactgagg 1543561 ctcaccgatc ctaacgatct gcttcattca ggagtcgaga ttatcgctca gccgccgggg 1543621 aaaaagctgc aaaacttaaa cctcctgtca ggcggagagc gtgcgcttac tgctatagcg 1543681 ctcttattct caatcctaaa ggttcgtcca gtgccgtttt gcgtccttga cgaagtagag 1543741 gctgcgctcg acgaagcgaa tgtgttccga tttgcgcagt atttaaaaaa atacagcagc 1543801 gatactcagt ttattgtgat tacccacaga aaaggaacga tggaggaagc ggatgtgctt 1543861 tatggcgtaa ccatgcagga atccggtgtt tccaaggtaa tttcagttaa gctggaagaa 1543921 acaaaagaat tcgttcagta acgaggaaag aggttaaaag atgagctttt ttaaaaaatt 1543981 aaaagagaaa atcacaaaac agacagattc cgtatctgaa aagtttaagg atggccttga 1544041 aaaaacaaga aactcctttc aaaacaaagt gaatgatctt gtatcccgtt accgtaaagt 1544101 ggatgaggat ttcttcgaag agcttgaaga ggttcttatc agcgcggatg tcggttttac 1544161 aaccgttatg gaattaatag atgagctgaa aaaagaagtc aaacgcagaa atattcaaga 1544221 tccaaaggaa gtccagtcag tgatttctga gaaactggtc gagatttata acagcggaga 1544281 tgagcaaatt tcagaactga acatccagga tgggcgttta aacgtaatcc ttctggtagg 1544341 tgtaaacggc gtcgggaaaa caacaacgat cggaaagctt gctcataaaa tgaaacaaga 1544401 aggaaaatct gttgtacttg ccgccggaga cacttttaga gcgggagcca ttgaacagct 1544461 ggaagtatgg ggagagcgta caggagtgcc tgtcattaag cagacggcag gaagcgatcc 1544521 ggcggctgtc atctacgatg ctgttcatgc tgcgaaagca agaaatgccg atgtattaat 1544581 ttgtgatacg gcagggcgtc tccaaaacaa agtaaatctc atgaaagagc ttgaaaaagt 1544641 aaaacgtgtt atcgaaagag aagttcctga agctccgcat gaggtgctgc ttgcccttga 1544701 tgccacgacc ggccaaaatg caatggctca ggcaaaagaa ttctctaaag caacaaatgt 1544761 taccggcatt gctttaacga agcttgacgg tacggcaaaa ggcggtatcg tccttgcgat 1544821 tcgcaacgag cttcacatcc cggttaaact agtcggttta ggagaaaaag ttgatgacct 1544881 tcaggaattt gatccagaat cctatgtgta cggactcttt tcagatttag tggaaaaagc 1544941 cgacgattaa gaaaaaggcc ccaacatctt ggggcctttt tcttttttat cttcttactt 1545001 gataggcgaa atgataaagg ctgttatcag tggataccag tcttgactca ccagaaaaaa 1545061 ctctgaatgg gatgatgtca tagtaatgaa cggaaacaga tgtgtaatac gtatagtaac 1545121 cagcagctgg ccccaaatac attggaacct caaatgttcc gtttgcatca gtcgttcctg 1545181 aagcagtttg tgttgtgttt ccgaccttcg tgtccgcttc aaatcttacg ggcgcgtttg 1545241 gcactggctg tccgttttgg tcgagtaatt tgccgcttac tgtaatattg tacttgactc 1545301 gccaatattg accttgtccg taattgattt taccgtatac ccctccatct gtgctgatat 1545361 ttgtgattga ggccttataa ggtgcctcag cagcgtctgc ttgctgtgcc gggaaaccta 1545421 ttgtaaacag ggctgccaga cataacataa acaataaacc gatttttttc ataaaaatcc 1545481 tccttaaaat agggttcata tacaatatcg gaataaattg gatgatattt agcgtatttt 1545541 ggaaaagtta atcgccgctt tgacaagata aaaacttgac agtgtcatta aaaccgtgta 1545601 aactaagtta tcgtaaaggg atttgactta acaaagggga gagctcaaat gtcactcgaa 1545661 aagacaacga gaatgaatta tctgtttgat ttttatcagt cgttgttgac gtcaaaacag 1545721 aagagctata tgtcgcttta ttatttggac gatttctccc taggcgaaat agccgaagaa 1545781 tatgaggttt caagacaagc tgtttatgat aacatcaaac gaacagaagc aatgcttgaa 1545841 caatatgaag aaaagctgct ccttttgaaa aagtttcagg agcgtaaaga gatgtttaat 1545901 aagctgaagg agcttgcttc cggttcaaaa gaagaggaag aaattacagc tctgattgaa 1545961 gcgcttgaga aattagatta ggaggcggca aactatggca tttgaaggat tagccgaccg 1546021 actgcagcag acgatttcta aaatccgcgg aaaagggaaa gtcagcgaac aagatgtaaa 1546081 agagatgatg cgtgaggtcc gtcttgcgct gcttgaggct gacgttaact ttaaagtagt 1546141 caaggatttt gtcaaaaaag taagtgaacg cgctgtaggc caagacgtca tgaaaagtct 1546201 gacgcccggc cagcaggtca ttaaagttgt tcaagaggaa ctgactgagc tgatgggcgg 1546261 cgaagagagc aaaatcgccg tcgcaaaaag gccgccgact gttattatga tggtcggtct 1546321 ccaaggtgcc ggtaaaacga caacaagcgg taagcttgcg aatctgctgc gcaaaaagca 1546381 taatcgcaaa ccgatgctgg ttgctgccga tatttaccgc ccagccgcaa ttaagcagct 1546441 ggaaacactc ggcaaacagc ttgatatgcc tgttttctct cttggcgatc aggtcagtcc 1546501 tgtagaaata gctaaacagg ctattgagaa agccaaggaa gaacattatg actacgtcat 1546561 tttggatacg gcagggcgct tgcatatcga ccatgaactg atggatgaac tgaccaacgt 1546621 caaagaaatc gcgaatccgg aagaaatttt cctggttgtc gattcaatga ccggtcagga 1546681 cgctgtgaat gttgccaaaa gctttaatga acagctcggt ttaaccggtg ttgtgttgac 1546741 taagctggat ggagacacac gcggcggggc tgcgctttct attcgcgctg tcacaaacac 1546801 gccaattaag tttgcaggtt tgggcgaaaa gcttgatgcg ttagagccgt tccatcctga 1546861 acgcatggca tcaaggattc tcggcatggg cgacgtgctg acattgattg aaaaagcaca 1546921 ggccagcgtt gatgaagaca aagccaaaga gctggaacaa aaaatgagaa cgatgagctt 1546981 cacattggac gattttctgg agcagctcgg gcaagtcaga aacatggggc cgcttgatga 1547041 gcttctgcaa atgatgccgg gtgcaggtaa aatgaagggc ctgaaaaaca tccaagttga 1547101 tgaaaaacag ctgaatcatg tggaagcaat catcaaatca atgactgttc ttgaaaaaga 1547161 acagccggat attatcaatg ccagccggcg gaagcggatt gcaaaaggaa gcgggacatc 1547221 cgtacaggaa gtcaaccgtc tgcttaagca gtttgatgaa atgaaaaaaa tgatgaagca 1547281 gatgacaaac atgtcaaaag gcaagaaaaa agggtttaag ctacctttta tgtaatcggt 1547341 tatacatgat aaaaccgttg ttaagaaaaa acactttaca aacactttta tcattgttaa 1547401 tatactatct tgttgaaata ttttcggagg tgctagtaaa atggcagtaa aaattcgttt 1547461 aaaacgtatg ggagcaaaaa aatctccttt ctatcgtatt gttgtagcag attctcgttc 1547521 accacgtgac ggccgtttca tcgaaacagt cggaacttac aacccggttg caaaaccagc 1547581 ggaagtaaaa attgacgaag agcttgctct taaatggctt caaactggag cgaaaccatc 1547641 tgatacagtt cgcaacttgt tctctagcca aggaatcatg gaaaaattcc acaacgctaa 1547701 acaaggcaag taatgactga tcaacacttg gaagatttga ttgtccacat tgtgacgccg 1547761 cttgttgatc atccagatga cattcgcgtc ataagagaag aaaccgatca aaagattgcg 1547821 ctgcgcttat ctgtccataa gtcagatacc ggtaaagtta tcggaaagca aggccggact 1547881 gcaaaagcga ttcgaacagc tgtatttgca gctggcgtac agtcttctaa gaaagttcaa 1547941 tttgaaatat ttgactaaaa gggagagggc cggcacctcc ccttttttta cacgcaaaaa 1548001 aagggtaaac tgatagaagc ttaggcaaaa tagaaaagcc tggacgagta aaagttttaa 1548061 aagcggggag cttggtgcga tgcaaattat tcaccgtgta gccgttatgc aagtcttaac 1548121 cgagcgcagt aaagaaaagc ttttagcttc ttttgctgag aagaaacaaa tgcttgaacg 1548181 agaatgcagc cagctctatt ttcagcttag aaaacatgag aaagaacagc aaaaccctaa 1548241 tatgattgaa caatttaaaa aggcaataga aaagcgaaaa gatgatataa aaatcattga 1548301 ttttcaaatt gctcaagtac atacattgcc gcttggcagt gagttgaaag aaaaggaagt 1548361 cgatgcgctg ctgacgattg aagccgggga tgactggcat gagaaaacag cagcgaacac 1548421 catcgtcata aaagacggaa aagtaattga aattcgccag aggtgatcat atgacaaagc 1548481 gatggtttaa tgtaggcaaa atcgtaaata cccacggaat caaaggcgaa gtgcgggtga 1548541 tttcaaaaac agattttgcc gaagaacgat acaagccggg aaacacgctg tatttgttta 1548601 tggacggccg taacgaacca gtggaggtaa cggtaaacac acatagactg cataagcaat 1548661 ttcatctcct gcagtttaaa gaaagacaaa acctaaatga agtagaagag ctgaaaaacg 1548721 caatcattaa agttcctgaa gaagaattag gagagctgaa tgagggtgaa ttttatttcc 1548781 acgaaattat tgggtgtgaa gtatttactg aagaaggcga actcatcgga aaggtcaaag 1548841 aaattttgac gcctggagcc aatgacgttt gggtcatcgg acgaaaagga aaaaaagacg 1548901 cactcattcc ttacattgaa tcagtggtta aacatatcga tgtcagggaa aagaaaattg 1548961 agattgaact catggaaggg ttaatagacg aatgaaaatc gattttttga cgctgtttcc 1549021 cgaaatgttt gaaggcgtgc tcggctcatc gattcttcaa aaagcccagg aaaaagatgc 1549081 ggtgcagttt caagtcgtaa atttccgaga gtactctgat aacaagcaca atactgttga 1549141 tgattatcct tatggcggcg gggcaggcat ggttctcaag ccccagcctg tttttgacgc 1549201 ggtcgaggac ctgacatcaa aggcagccgc tgctccgcgt attatcctcg tatgcccgca 1549261 aggtgagcgt tttacccaaa aaaaagccga acaattagct aaggaagagc atttgctgtt 1549321 catttgcggc cactatgaag gctatgatga acgcattcgc gagcacttgg taacggatga 1549381 aatatcaatt ggcgactttg ttctgacggg cggtgagctc cctgcaatga tgatcgcaga 1549441 cagtgtggtc agactgcttc cgggtgtact gggtaaagag gcttcccata ttgaggattc 1549501 cttcagcacc ggacttttag agcacccgca ttatacaaga ccggcagatt acaaaggttt 1549561 aaaagtgcct gaaacactct tgtcaggaaa ccatgcaaaa attgaagaat ggcggaataa 1549621 agaatcgatc agaaggacct acctaagacg tccggatctg ttgaaagacc acccgcttac 1549681 agagcagcaa agaaagtgga tttctgaatg ggaaaaagaa tagattttat tgcataggct 1549741 atgaaattgt gataagatac tacttgtggc ttaagcgggc ttatccgctg caagcttgaa 1549801 aacgatgttc cgctgtgccg gtttttgtgg ccaagagcat ctgttggaag gagttgaaaa 1549861 cgatgcaaaa actaattgaa gatatcacaa aagaacagct tcgtactgat cttcctgcgt 1549921 tccgtcctgg tgacacttta cgtgtacacg ttaaagttgt tgagggtaac cgtgagcgta 1549981 tccagatctt tgaaggtgtt gtgattaagc gtcgtggtgg tggaatcagc gaaacgttca 1550041 cagttcgtaa gatttcttac ggtgttggcg ttgaacgtac tttcccagta cacacaccaa 1550101 aaatcgcgaa aatcgaagtt gtacgttacg gtaaagtacg ccgtgctaaa ctttactacc 1550161 tgcgtgaact tcgcggaaaa gcggctcgta ttaaagagat cagacgataa tgataacgaa 1550221 cgaaaagagc ttgttacctg taacaagctc tttttttata cagaatttga aaatgccgga 1550281 caggcatcgt aaaatacata aaggacaaca atgaatcatg catactgaag ataaaggcgg 1550341 tgttcgtgtc acatgacaat tcaatggttc ccgggccata tggcaaaagc aagaagggaa 1550401 gtaaccgaaa aattaaaatt aatcgatatc gtatatgaat tggtagatgc cagaattcca 1550461 atgtcatcaa gaaacccaat gattgaagat attctaaaaa acaagccgcg aattatgctg 1550521 ttaaacaagg ctgacaaagc agatgcggca gttacacagc agtggaaaga gcactttgag 1550581 aaccagggga tccgctctct gtctattaat tctgtaaatg gacaagggtt aaatcaaatt 1550641 gtgcctgcat caaaagagat cctccaagaa aaatttgacc ggatgcgtgc gaaaggtgtg 1550701 aagccgagag cgattcgcgc tttgattatc ggcattccaa acgtcggaaa atcaacgctc 1550761 atcaaccggc ttgcaaagaa aaacatagca aaaacgggag acagacctgg tattacgact 1550821 tctcaacagt gggtcaaagt tgggaaagaa ttagagctat tagatacacc gggaattttg 1550881 tggcctaaat ttgaggatga gcttgtcggt ttgagactgg cagtcaccgg ggctattaaa 1550941 gactcgatta tcaatttgca ggacgtggcc gtgtttggtc ttcgttttct cgaagaacat 1551001 tacccagaac ggcttaaaga gcgttatggc cttgatgaga tcccagagga cattgccgag 1551061 ctgtttgatg caataggtga aaagcggggc tgtctcatga gcggtgggct catcaactac 1551121 gataagacga ctgaagtcat cattcgcgat attcgcactg aaaagttcgg caggctgtca 1551181 tttgaacagc cgacgatgta aaggcgcgca gaaatgcggg tctttatttt ttcttggctg 1551241 aaccgataca tacagtaagg gagaagagaa agtgaataca ttaaccgtaa aggacattaa 1551301 agaccgtttg caggaagtga aggatgcaca agacccattt attgcccaat gcgaaaacga 1551361 cccgagaaaa agcgttcaaa cgcttgtaga gcaatggctt aaaaagcaag cgaaagaaaa 1551421 agcgctgaaa gaacaatggg tgaatatgac ttcctatgaa aggctggcaa gaaacaaagg 1551481 atttcgcttg attgcaggtg ttgacgaggt cggccggggg ccattggcag gaccagttgt 1551541 cgccagcgca gtcatccttc cagaggaatg tgaaatactt gggctgacag actccaaaaa 1551601 gctttcagag aaaaaacgcg aggaatatta cgagcttatt atgaaggaag cactggcggt 1551661 cgggatagga attgtagaag ctactgtgat tgatgagatc aatatatatg aagcttcaaa 1551721 aatggcaatg gtgaaagcga tacaggattt gtcggataca cctgattatt tgcttgttga 1551781 cgcaatgaca cttccgctcg acacggctca ggcgtcaatt ataaaaggcg atgccaaaag 1551841 cgtgtctatt gcggcaggtg cgtgtatcgc aaaagtgacg agggaccgaa tgatgagcgc 1551901 ttatgccgaa acgtatccca tgtacggctt tgaaaaaaat aaaggctatg ggacaaaaga 1551961 acatttggaa gctctcgctg catacggccc aactgaattg caccgcaaaa ctttcgctcc 1552021 tgttcaatct ttcagataaa tcaccatgga caaggaggca cctttttaaa atgaacatac 1552081 gaaatgatgt gcaaaaggcg ctgcagcacc ttttcgggcg tacagccgtc ccgcaggaaa 1552141 catcaaaagt aaacgaagcg ctaaacgggg agaagcgtct cctcttagga aaagtgcttc 1552201 gtttactagg agatcagcat gccctgatcc aagtcggcaa tcaaactgtt cagggaaaac 1552261 ttgaaactca gcttcgtcct caggcatact attggttttc ctacgaaaaa aaaacggcag 1552321 agcaaacagg ccgtcttcag gtcgttcaaa gctttgatca aaatcctaaa accattcagg 1552381 atgcagctgg caaactttta aatgctattt cagtgaagac gtcaaacgca gctctcatga 1552441 tgacaggagc gatgctgaaa agcaaaacac ccgtaacaga aaatgatatc aaaacagctg 1552501 tccgctggat ggacacgctg ccttcgcaag acacaaaaaa agcagttgaa acggttctct 1552561 tcgctttaaa gcgtgatctt cccattcact ccgagatttt gaatggtgtt cacgctgtga 1552621 aatcgcctgt tccgttgcat cagcacgtat cccagctgct acaggcaatc gaccaaaacc 1552681 ctcagcagag ccaaatgatg tcaaagctaa aggaagcagt cacggtgctt ttaaatagtg 1552741 aaatcgatgt ccatgcagaa cggctgattg ataagcttat ttctttaacc gacaatacga 1552801 aagcaccttc tccgacgaat acagctggaa gcagggagct tagcacacca gctggctccc 1552861 ccggaaaagc cagcctgccg attgcaaatc acacagcaga acagggaagc atacaagaag 1552921 agcctgttaa aacagcagca gacattccaa ttaaagaagc ccgccagctg ctggtgaagc 1552981 tgacggaatc tgctgaaaaa aacagtctcc aaattgtgaa agaagcagca aattggatta 1553041 aagcggctgc ttcatcgggt gatagtaagt cacttgcagc ttcagctgtt ttacaggcgg 1553101 cacaagtcac agatcaggaa gccgaagtct ttttaaaggc tgttcagcag acagcacccc 1553161 atttggcgga taaggcagat gttctttctt tcttatccaa agtgaaaacg gcaatcggcg 1553221 caagggacga ggttgcgttc attaaagcgt ttgaacaagg aagcgcagtc acatctggcg 1553281 aaatgcaatc catcaagctg gctctttctg ccttaagagc atcgcatgag gtagccgaac 1553341 cagtcaaaca agaagccgat cagctttttc ataaattaaa tggccagctt ttcatgcagc 1553401 aggaccatcc atcatacagc caaattgtaa tgtcatttcc gatgttttcg aagtcagggg 1553461 ttcaggacat gactgttctg tttaaaggaa agaaagaagc ggatggaaag cttgatcctt 1553521 cccattgccg ccttttgttt ttgctgcagc ttgatacact aaaagaaacc gtcgttgatt 1553581 gcttggtaca gcaaaaagtc atgaccatta caatagagac tgatttcgag ctgcaggctg 1553641 cgatcgatcc gatggtgccc gcgcttaaac aggggctaaa ggaaatgggg tacagccttt 1553701 caggggtaaa cgctaaaaaa agggttcaca ccgaagaaaa ggcttcaatc gatcaatata 1553761 taacaagtat cagtgatcag gaagtggatg tgaaaatatg aaagagcaga caccgatcag 1553821 aaaagctgtt gctctccatt atgacgaaca aaaagacaag gcgccgagag tgattgccac 1553881 agggaagggc catgtagctg acaacattat aaaagaagcg aaaaaagcag gggtcccgat 1553941 tcaagaagat cggacccttg tcgaattaat gcgccatttg acggtagatg atcaaattcc 1554001 tgaagctctt tatgaaacgg tagccgagat tttttcattc atttacaaat tggacgaaag 1554061 cgtaaaaaac aaaaaatagc taaaatattc cccatccttc tttgaaattt atgtttttaa 1554121 taaagtaaaa gtttgaatgt ttagaaggat taaaagattt tgcatcgaac tgtagacaat 1554181 tcttccagta ttattataga atgaaagcgc agtctatttt agttttgtta cataagttag 1554241 gaggatggga aatgaatatc catgagtacc agggaaaaga agtcctcaga aaatatgggg 1554301 tatctgttcc tgaaggtaaa gtggctttta cagcagaaga agcagttgag agtgcaaaga 1554361 gcttatccag ctcggtttat gtcgtaaagg ctcaaattca tgctggcggt cgaggcaaag 1554421 ctggtggggt aaaaatagca aaatcattag acgaagtaaa agcgtatgcc gaagaactat 1554481 tagggaagac cctagttaca catcagacgg gtccggacgg ccaagtaata aaacgcttac 1554541 ttattgaaga aggctgcgat attaaaaaag aatattacat cggtctagtg cttgaccgcg 1554601 ccacttcaag aatcgtttta atggcttctg aagaaggcgg aacggaaatt gaagaggttg 1554661 cggagaaaac accagaaaaa atcaaaaaag ctgtcattga tccagctgtt ggccttcaag 1554721 gctatcaagc cagagaaatt gcattcgcta ttaatattcc aaaagagctc gtgggaaaag 1554781 ctgctaaatt tatgcttgga ctatataaag cgtttgttga gaaagactgc tcaatcgccg 1554841 aaatcaatcc gcttgttgtg actggcgacg gaaatgtgat ggcgcttgat gcaaaattga 1554901 attttgacag caatgcgttg taccgacaaa aggacattat ggaatacaga gatttggatg 1554961 aagaagatcc gaaagaaatt gaagcgtcca aatatgatct aagctacatt tcccttgatg 1555021 gaaatatcgg ctgtatggta aacggcgcgg gacttgcaat gtctacgatg gatattatca 1555081 agcattatgg aggagaaccg gccaacttcc ttgatgtggg cggcggtgca accgcggaaa 1555141 aagtcacgga agcatttaaa atcattcttt ctgatcaaaa cgttaaaggg atttttgtca 1555201 acattttcgg cggcattatg aaatgtgatg tcatcgcaga aggggttgtt gaagcgacta 1555261 gacaagttgg tttgacattg ccgcttgtcg tccgtcttga aggcacaaac gtggatctag 1555321 ggaagaaaat ccttagtgaa tcaggattaa acattacatc tgcggaatca atggctgacg 1555381 gcgcgcagaa aatcgtatcc ttagtttaag aaagaatgaa aggcagggga ccaaataatg 1555441 agtgttttca ttaataaaga tacaagagtt attgtgcaag ggattacagg ttctaccgct 1555501 ttatttcata cgaagcagat gcttgaatac ggcacaaata tcgttggcgg tgtaacacct 1555561 ggaaaaggcg gaacagaagc ggaaggtgtt cctgtattta atacagtggc tgaagcagtt 1555621 caaacaaccg gcgctaacgc gtctgttata tatgtgcccg caccgtttgc agctgatgcg 1555681 attatggaag cggtagatgc ggagcttgat ctcgtgattt gtatcacaga acatatcccg 1555741 gttttggata tggtgaaggt caaacgcttc atggaaggca agaaaacgag actgataggg 1555801 ccgaactgtc ctggtgtcat tacgcctgaa gaatgtaaaa tcggcattat gcccggatac 1555861 atccataaaa agggtcatgt aggcgttgta tcacgttcag gaacattaac atacgaagcg 1555921 gtgcaccagc tctcagaagc gggtgtaggg caatctacag ctgttggaat cggcggcgac 1555981 cctgtaaatg gaacaaactt tattgacgtt ttaaaagcgt ttaacgaaga tcctgacaca 1556041 cacgcagtca tcatgattgg cgaaatcggc ggtacggccg aagaggaagc ggcagagtgg 1556101 gtaaaagcca acatgacaaa accggtagtc ggttttattg gcggtaaaac agcacctcct 1556161 gggaagcgca tggggcatgc aggcgccatt atttccggcg ggaaagggac agctgatgaa 1556221 aaaatcaaaa cccttaatgc atgcggaatc gaagttgcag agacaccttc tgtcatgggt 1556281 gaaaccttaa tcaaggtgct gaaagagaag aacttgttcg aaacttgtaa aacgcattaa 1556341 taaaaaaggg acagccgtca aggctgttcc tgctttttct aacaaaagga ggtcaatcta 1556401 ttggatcagg ccgctgtctg cctaacgatt tgcagaatca atcaattatt atccccatcc 1556461 cttctattaa aatggtggaa agccgatccg tctatgtcgc tgacatcacc cgtgttacaa 1556521 acggttactc gtgatcaaat aaaagcagct gcattaaaaa acgaaataga acaattttat 1556581 ccaaagctcc cgcgtgtact tgctgcttat cgtgagcaag gcattaacac catccctatt 1556641 tcttcaaagc aatatccttt ctggcttaaa agcatttatg atccccctgc cgtactgttt 1556701 gcaaaaggtg atatgactct tctttcgaaa gggagaaaaa ttggaattgt aggcacaaga 1556761 aatccaacag cttatgggaa acaagttgtc aatcatctta caaaagagat ctgtcgtaaa 1556821 ggttgggtga ttgtcagcgg actggcgtct gggatagacg gaatgtccca tgctgcaagt 1556881 attaaggcga aggggcggac aattggcgtc attgcaggcg gatttcaaca catttatccc 1556941 cgagaaaacc ttcagttagc agatcacatg gctaaacacc atatcctgct gtcagagcac 1557001 ccacctgaaa ctaaacccca aaaatggcat ttccctatga gaaaccgtat tatcagcgga 1557061 ctaagtgaag gcgttattgt cgttcagggc aaagaaaaaa gcggttcgct gattactgcc 1557121 tatcaagcat tggaacaagg gagagaggta tttgccgtac ccggttcatt gtttgaccct 1557181 tacgccggag gtcctataaa actgatccag cagggggcta aagccatatg gtcagcagag 1557241 gatattttcg aggaacttcc tgagagaaac gttcaatata cggaaccctt ttgaattatc 1557301 gtttgacaaa cggtattgta atatttaata atagtgagga tttaaagttg catattgttt 1557361 tctatttaat taatgacgtt catgataaag aatgaaatgt tgaaagccaa ataaagacag 1557421 ctgcaaaaat aaaattgaaa tatcttgaaa agagagagaa cacctcttga gggggatgaa 1557481 aatgtctgat tatctagtca tcgtggaatc gcccgctaag gcgaaaacga ttgaacgtta 1557541 cttaggtaaa aaatataaag taaaagcatc aatgggacat gtccgggatc ttccaaaaag 1557601 tcaaatggga gttgacatag aacagaattt tgaaccgaaa tatattacca ttcgaggtaa 1557661 aggcccggta ttaaaagagc tgaaaacggc tgcgaaaaaa gccaaaaaag tgtatctcgc 1557721 agctgacccc gacagagaag gggaagcgat tgcatggcat ttggcacaca gtcttgattt 1557781 agatctcaac tcagactgcc gtgtggtgtt taacgaaatt acaaaagacg ctattaagga 1557841 atcgtttaag catccccgca tgatcaatat ggatttagtg gatgcacagc aagcgagacg 1557901 tattttagac aggcttgtcg gatataaaat cagtccaatc ttatggaaaa aagtcaaaaa 1557961 agggcttagc gcaggacgcg tgcaatccgt tgccctccgt ttgattattg accgtgaaaa 1558021 agagattaac gactttaagc ctgaggaata ttggacaatt gacggtacgt tcttaaaagg 1558081 tcaagaaacc tttgaagcga gctttttcgg gaaaaacggc aaaaaacttc ctttaaatag 1558141 tgaagctgat gtaaaagaga ttctttctca gctcaaaggg aatcaatata cagttgaaaa 1558201 agtaaccaaa aaggaacgca aacgtaatcc tgctttgcct tttaccactt ctaccctgca 1558261 gcaggaagcg gctcgcaagc tcaatttcag agcgaagaaa acgatgatga ttgcacagca 1558321 attatatgaa ggaattgatt taggaagaga aggaacggtt ggtctgatca cgtatatgag 1558381 aacggattca acccgtattt caaatacggc tgttgatgaa gcagctgcat ttattgatca 1558441 gacatatgga aaagagttcc taggcggaaa acggaagcct gcgaaaaaga atgaaaatgc 1558501 ccaggatgcc cacgaagcaa ttcggccgac atcagttctt agaaaaccaa gtgaattaaa 1558561 agcagtcctc ggcagagacc aaatgagact gtataaatta atttgggagc gttttgttgc 1558621 cagccaaatg gcaccggctg ttctcgatac aatgagtgtc gacctgacaa acaacggttt 1558681 gacatttcgt gcaaatggaa gtaaagtcaa gttttccggg tttatgaagg tgtatgttga 1558741 aggaaaagac gatcaaatgg aagaaaaaga ccggatgctg cctgacttac aagaaggcga 1558801 cacggtatta tcaaaagata tagaacctga gcagcatttt acccagccgc ctccgcgata 1558861 tactgaggcc cggcttgtta aaacccttga agaacgcggt atcggccgtc catccacata 1558921 tgctccgaca cttgatacta ttcagcggcg cggctacgtg gcattggata ataaacgttt 1558981 cgttccgact gaattaggtc agatcgttct tgacttgatc atggagtttt tccctgagat 1559041 cattaacgtt gagtttacag ctaaaatgga gagagatctt gatcatgttg aagaaggaaa 1559101 taccgaatgg gtcaagatta tcgataattt ctacaccgat tttgaaaaac gcgtcaaaaa 1559161 agccgaatcg gaaatgaagg aagttgagat tgaaccagag tatgctggag aggattgtga 1559221 attgtgcagt tctccaatgg tatataaaat gggacggtac ggtaaattct tagcttgctc 1559281 caacttccct gactgccgga acacgaaacc gattgtgaaa caaatcggtg tgaagtgccc 1559341 gagctgcgga gaaggaaaca ttgttgagcg aaaatcgaaa aagaaacggg tgttttacgg 1559401 ctgtgaccgt tatccggact gtgaattcgt atcatgggac aaaccaattg aacgaaaatg 1559461 cccgaaatgc ggaaaaatgc tcgtcgagaa aaaactcaaa aaaggtatac aagtccaatg 1559521 cgtggaatgc gattataagg aagaaccaca gaagtagcgg tgagcagggt cttgctcacc 1559581 ttctttgtgt gttaaaagaa ggccttgaat aataaactag gagatgtgaa agatgaacca 1559641 acaaacagtg aatgtaatcg gagccggact cgcaggaagt gaagcagcat ggcagcttgc 1559701 caaacgtggg attcaagtca aattgtatga aatgcggcca gttaaacaaa cgcctgcgca 1559761 tcatacagat aaatttgctg agcttgtctg cagcaactct cttcgctcta atacacttgc 1559821 taacgctgtc ggtgtattaa aggaagaaat gcgtgcgctt gattcagcca ttatcgctgc 1559881 ggctgacgaa tgttcggtgc ctgccggggg cgctcttgca gtagaccgtc atgaatttgc 1559941 cgcaagtgtg acaaatcggg tgaaaaatca tccaaacgta accgttatta atgaagaagt 1560001 gactgaaatt cctgaaggcc ctactatcat cgcaacgggt ccgttaacat ctgaatcgct 1560061 gtctgcccag ctgaaggagc tgactggaga ggactattta tatttttatg acgcagcggc 1560121 gccaattgta gaaaaagaca gccttgatat ggataaagtg tacctgaaat cccgttatga 1560181 taaaggtgaa gcagcatatt tgaactgccc gatgacagaa gaagagtttg accgttttca 1560241 tgaagcatta acatcagcag aaacagtgcc gttaaaagaa tttgaaaaag agattttctt 1560301 tgaaggctgc atgccgattg aagtcatggc aaaacggggt aagaaaacaa tgcttttcgg 1560361 tccgatgaaa ccagttggtc tagagcatcc tgttacagga aaacgccctt atgccgtcgt 1560421 tcagctcaga caggatgatg ctgcgggaac actttataat attgtaggat tccagacaca 1560481 tttaaaatgg ggagaccaaa aggaagttct caagttgatt ccaggacttg aaaatgtaga 1560541 aatcgtcaga tatggcgtga tgcatagaaa cacatttatt aactctccaa gcctgttaaa 1560601 gccgacttat caatttaaaa accgcagtga tctgttcttt gcaggccaaa tgacgggagt 1560661 agaaggatat gtggaatcag ctgcctcagg acttgtagca ggcattaatg cggcgaagct 1560721 tgtattggga gaagagcttg tgatcttccc tcaggaaaca gcaattggca gtatggcaca 1560781 ttatattaca acaacaaacc agaagaactt ccagccgatg aatgcaaact ttgggctttt 1560841 gaaagaattg ccagttaaaa ttaaaaataa aaaagaacga aatgaacaat acgcgaaccg 1560901 tgcgattgaa acaattcaaa caatttcgaa aacaatatag gtattgattg caacctgagc 1560961 gcgatttgtg ataccattta aaagcccttc ctggggaggt attaggcatg gagaatgtta 1561021 agaatttcgt aaagttattc gttgaatatt tacaaattga aaaaaattat tcacaatata 1561081 ctattgtgaa ttatgtggat tcaattgaag aattcgagac tttcctgcgc gttcaaggta 1561141 taaatggatt tgaagaagct gcatatcaag atactaggat ttttttgaca gaagcctatg 1561201 aaaaaggttt atcgagaaga acaataagca aaaagatatc tgcattaaga agcttttata 1561261 agtttctgat gcgggaaaag cttattgaag aaaatccgtt tcagcttgtt catctgccaa 1561321 aacaggagaa acggataccg aagtttctat atcaaaaaga gcttgaggag ctgtttgaag 1561381 tttcagatat aagccagccg gccggaatga gggatcaagc gctgttagag ctgctctatg 1561441 ccactggaat gagggtcagt gaatgctgtt ccataactat taacgacgtt gatttattta 1561501 tggacactgt gcttgttcac ggtaaaggca agaagcagcg ctatatcccc tttgggtctt 1561561 atgcccgcga agcgttgaag gtatacatga atagcggaag acagtgcttg ctgatgaagg 1561621 caaaagaacc tcatgatcta ttattcgtaa atcaaagagg cggaccgctt acagcccgtg 1561681 gcatcagaca tattttaagc gggcttgttc aaaaagcgtc aagcacttta catatccatc 1561741 cgcatatgct tcgacatacg ttcgccacgc atctgttaaa tgaaggagcg gatttgagaa 1561801 gcgttcaaga actgctcggg cattccaatc tgtcttctac acagatatac acgcacgttt 1561861 cgaaggaaat gttgagaaac acatatatgt ctcaccatcc aagagcattt aagaaaaatt 1561921 aaaggaggcc ctttatgtca tcttttcatg cgaccacaat atttgccgta cagcataaag 1561981 gacgaagcgc tatgtccgga gacggccaag taacatttgg tcaggctgtt gtcatgaaac 1562041 acacggcacg gaaagtgaga aaactgttta acggcaaagt tcttgctggt tttgcgggat 1562101 ctgttgcaga cgctttcact ttattcgaaa agtttgaagc taagcttgaa gaatataacg 1562161 gcaacttaaa acgggcggct gttgagcttg caaaggaatg gcgcagtgat aaagtgctaa 1562221 gaaagctcga agccatgctg attgttatga atcaggatac tttgcttctc gtatcgggaa 1562281 caggcgaggt gatcgaacca gatgacggca ttctcgcgat tggatcagga ggcaattacg 1562341 ctttggcagc gggaagagca ctgaaaaagc atgccgggga aagcatgtct gcaagtgaga 1562401 ttgccagagc cgcgttagaa acagcaggcg aaatttgtgt ttacacgaac gatcaaatca 1562461 tactggaaga gcttgaatag aaaggacttg aggcgcatgg aaaaaaaacc gttaactcct 1562521 agacagattg tagatcggtt agaccaatat attgtcggtc agcaaaatgc gaaaaaagct 1562581 gtcgccgtgg cattaagaaa ccgctataga agaagtcttc tggatgaaaa gctgaaggac 1562641 gaggtcgttc cgaaaaacat tttaatgatg ggtcctaccg gcgtcgggaa aactgaaatt 1562701 gccagacgaa tcgctaagct ttcaggtgcg ccatttatca aaattgaagc tactaaattt 1562761 accgaagtcg gctatgtagg cagagatgtt gaatcaatgg tcagagatct tgtggagact 1562821 tctgttcggc ttataaaaga agagaaaatg aatgaagtaa aggaacaggc agaagaaaat 1562881 gcaaacaaac gcattgttcg tctgttagtt cctgggaaga aaaaacaatc tggtgttaaa 1562941 aatccgtttg aaatgttttt tggaggcagc cagccgaatg gtgaagatga ggcggagagc 1563001 caggaagaag caaacatcga agaaaaaaga aaacgaatgg cgcatcagct ggctttagga 1563061 gagctcgaag actactatgt aacagtagaa gtcgaagaac agcagccttc tatgtttgac 1563121 atgctgcagg gctcgggtat ggagcagatg ggtatgaaca tgcaggatgc gctgagcgga 1563181 ttaatgccaa agaaaaagaa gcggcgcaaa atgacagtca gagaagccag aaaagtcctg 1563241 acgaatgaag aagcaagcaa actcatcgat atggatgaag tcggccagga agctgttcag 1563301 agagcagaag agagcgggat tatctttatc gatgagattg ataaaatcgc aaagaacggc 1563361 ggtgcatctt cttctgccga tgtttcaaga gaaggtgttc agcgggatat ccttccgatt 1563421 gttgaaggtt ctaccgttgt cacaaaatat ggttctgtaa aaacagacca tgtattattt 1563481 attgcagcag gagcgtttca tatggccaaa ccgtctgatt tgattcctga gctgcagggg 1563541 cgtttcccga ttcgtgtaga actgaacaaa ctcacggtag acgacttcgt gagaattttg 1563601 gttgagccgg ataatgcgct gctgaaacaa tatcaggcat tattgcagac agaaggtata 1563661 tctcttgaat tttctgacga agctattcat aagattgctg aagttgctta tcatgtgaac 1563721 caggacacag ataatatcgg tgcgagacgc cttcatacaa tacttgaacg cctattagaa 1563781 gatttgtcgt ttgaagctcc agatgtaacg atggagaaaa taacgattac accacagtat 1563841 gtcgaagaaa agctcggaac gatagccaaa aacaaagatt taagtcaatt tatattgtga 1563901 aaaatttaat atgaggaatg tttaggagga ttatttatca tggctttatt acaaaaaaca 1563961 agaattatta actccatgct gcaagctgcg gcagggaaac cggtaaactt caaggaaatg 1564021 gcggagacgc tgcgggatgt aattgattcc aatattttcg ttgtaagccg cagagggaaa 1564081 ctccttgggt attcaattaa ccagcaaatt gaaaatgatc gtatgaaaaa aatgcttgag 1564141 gatcgtcaat tccctgaaga atatacgaaa aatctgttta atgtccctga aacatcttct 1564201 aacttggata ttaatagtga atatactgct ttccctgttg agaacagaga cctgtttcaa 1564261 gctggtttaa caacaattgt gccgatcatc ggaggcgggg aaagattagg aacacttatt 1564321 ctttcgcgtt tacaagatca attcaatgac gatgacttaa ttctagctga atacggcgca 1564381 acagttgtcg gaatggaaat cctaagagaa aaagcagaag aaattgaaga ggaagcaaga 1564441 agcaaagctg tcgtacaaat ggctatcagc tcgctttctt acagtgagct tgaagcaatt 1564501 gagcacattt ttgaggagct tgacggaaat gaaggtcttc ttgttgcaag taaaattgct 1564561 gaccgtgtcg gcattacccg ttctgttatt gtgaacgcac tcagaaagct ggagagcgcc 1564621 ggtgttatcg agtctagatc attaggaatg aaaggtactt atatcaaggt actaaacaac 1564681 aaattcctaa ttgaattaga aaatctaaaa tctcattaat cacaaaaaga accctttttg 1564741 agggttcttt ttttatttca aataaaggaa atcaataagc tttatttcct gggttgaaag 1564801 tctttctatg taataatttt aataaatttt gcatttttct tcaaaaagtt tcaaaaatgc 1564861 cgaaaagaaa ggagaaaaaa cagaaattct gctattttca ggcttatatc aaggcgagaa 1564921 atgtagttct aacaatctag gactttatac ctagttgcaa aatagataat tgtgaggaca 1564981 tttttttaca cgaacttcat agactttatg cctgttattt cttacaataa gcatatagtt 1565041 ttacaattct cgacaaggat attgagggtg aaaaaaactg aaatggaggt aagtggattt 1565101 gagcttattt tctggaacga tacaaaatct tgaaaatgcc ttgagcagag cggatattaa 1565161 gcaaaaagtc ataactaata atatcgccaa tatagataca ccgaactata aggcaaaaaa 1565221 agtctctttc caaaatttat tagatcaaga atcctcgcgt cttgaagcga taaaaacaga 1565281 ctatcgtcat gttgattttt ctgatactga ttcgaattat tcaattgttg cgagcggaga 1565341 tacatcgtat cagcaaaacg gaaacaatgt tgatgttgac aaagagatga cagaattggc 1565401 gcaaaatcaa atcaactatc aagctttggt tgaaagaatg aacggtaaat ttaattcgct 1565461 gaagaccgta ttaacaggag gaaaatgatg acagcttttc atagcttaaa tgtttcagca 1565521 tcggctttaa cagctcagcg agtcagaatg gacgttgtat catctaactt agcaaatatg 1565581 gatacgacaa gagctaagca ggtgaatgga gagtgggtgc cttacagaag aaaaatggtt 1565641 tcccttcagt caaaaggtga atcgttctct tccattctca attctcaaat gagcggaagc 1565701 gggaatgctg gaaacggtgt gaaggtttca aaaattacgg aggatgattc ggattttaat 1565761 cttgtctatg atccgacaga ccctgatgca aacgctgaag gatatgtaca aaagcctaat 1565821 gttgatccat taaaggaaat ggttgatctt gtcagcagca ctagatcata cgaggcgaat 1565881 gtcacggcga tgaatgccac aaagggaatg ctgatgaagg cgttagaaat cggaaagtag 1565941 gtgaatgaat gtgattaatg caatttctcc ttttcaggtt caaaatactc aaaacactca 1566001 aaatgcaaca aatcaagtaa acaatagcca aaaaacagat tcttcaaatc aaacaagctt 1566061 ttcggagctt ttaaaaaact ctattagttc gttaaatgag tcccaagtag cttctgacaa 1566121 catgactaat gccttggctg caggaaaaga tgtaaatctt gatgaggtca tgatcgctgc 1566181 tcaaaaagct agcatctctc taactgcagc aacagagttc cgcaataaag ctgtggaagc 1566241 ttatcaggag attatgagaa tgcaaatgta gggggtctga cgatttagag aaagagtgga 1566301 atgaccgggg gttaacatga atcgtactct aatgcaaatg aaaaacaaaa cgagtgagtt 1566361 ttggaaaaat agatctaaat tacaaaagat tttaatggtt agtgctttag cggcaattat 1566421 tattattgga attattatta gtgtttttgc ttcaaattct aaaatggcgc cgctgtacaa 1566481 agatttgtct gccgaagaag caggacaaat caaagaagaa ttggatgcaa aaaaagtgcc 1566541 aaacgaactt tcgaatggcg gtacagtgat tagtgttccg gaggatcagg ttgattcttt 1566601 gaaagtgcag atggctgcag aaggacttcc taaaacggga tcaattgatt attcgttttt 1566661 tggacagaat gccggctttg gtttgacaga caatgagttt gatatggtga aagtgaaagc 1566721 tacacagaca gaactgtcaa acttgatcaa tgaaatggac ggtattaaaa attcaaaagt 1566781 aatgattaat ctcccgaaag acgctgtgtt tgtcggtgaa gagcaatctg cagcatctgc 1566841 atcaatcgtt ttgcagattc aaccgggtta tacacttgat caaagccaaa tcaacggatt 1566901 atatcatctg gtatctaaaa gcgtgccaaa cctaaaagaa gataacatcg tcatcatgga 1566961 ccaaaattct acatactacg acaaatcaga cagcgatgca gggtcctacg cggatagtta 1567021 ttcttctcag caaggaatta agtctcaagt tgaaaaagac attcaaaaac atgtacagtc 1567081 actgctgggt acgatgatgg gccaagataa agtcgttgtc tccgttacag cagacattga 1567141 tttcacaaaa gaaaatcgga cagaagacat tgtcgaacct gtggataaag aaaacatgga 1567201 aggcattgca gtcagcgctg aaaaggtatc tgaaacatat cagggcgacg gtgcagccaa 1567261 cggcggaact gccggaaccg gcgaggaaga tgttacaaat tataaggctg acggtgaaaa 1567321 taccgaaagc gggaactacg aaaaaaacag caacaaaatc aattacgagg ttaaccgaat 1567381 tcataaagaa atcgctgaaa gtccttataa ggtcagagat ttagggattc aagtaatggt 1567441 agagccgcct gatgccaaaa acactgcgtc gctatcaact gaaagacagg atgatataca 1567501 aaaaatcctt tcaactgtag tcagaacatc tttggataaa gatgaaacgc aaaatcagaa 1567561 tttatctgat gctgatatca ataataagat tgttgtttcc gttcagccat tcgacggaaa 1567621 agtcaatttg gatacaaata cggaagaatc ctcaggtatc ccgctgtggg catatattgt 1567681 aggcggtgtt ttaatcgcag cgatcattgt tctgatcatt atgcttatca gaaagaaacg 1567741 ggcgcaagag gatgaatttg aggaatatga gtatgaggtt cctcaagaac caatcaattt 1567801 gcctgatatc aacgaagagg aaaatgaaac agcggaatca gtcagacgaa aacagcttga 1567861 aaagatggcg aaagacaagc cggaagattt tgcaaaactg ctgagaagct ggctggccga 1567921 ggattaggag gaattagaaa tggcgagacg tgatcaagat aagcttacag gaaaacaaaa 1567981 agcagccatt ctcatgattt ccttggggtt agatgtgtca gcttctgtct ataagcactt 1568041 aaccgatgaa gaaattgaaa ggcttactct ggaaatatca ggtgttcgaa gcgtcgatca 1568101 tcaaaaaaag gatgaaatca tagaagaatt tcataatata gccattgcgc aagattatat 1568161 ttctcaaggc ggtttaagct atgcaagaca agttctggaa aaggcgcttg gagaggataa 1568221 ggcggagaac attctaaaca ggctgacttc ttctttgcag gttaaaccat ttgattttgc 1568281 cagaaaagcg gagccagaac aaattttgaa ttttatccag caagagcatc cgcagacgat 1568341 ggcgttaatc ttgtcttatt tagatccagt gcaggccggg caaattttat ccgagctgaa 1568401 ccctgaagtg caggctgagg ttgcgagaag aatcgcggtc atggatagaa cgtctccaga 1568461 aataattaac gaggtagaac ggattctgga acaaaaatta tcttctgcat ttactcagga 1568521 ttatacacaa acaggcggaa ttgaagctgt tgtggaagtg ttaaacgggg tagacagagg 1568581 gacagagaag acgatcttgg attcattgga aattcaggat cccgatcttg ctgaagagat 1568641 taaaaagcgg atgtttgtct tcgaagatat tgtcacactt gataaccgtg caattcagag 1568701 agtcattcgc gatgttgaga acgacgattt gctcctttca ttaaaggttg caagcgagga 1568761 agtcaaagaa attgtgttca acaatatgtc acagcgtatg gttgaaacct tcaaagaaga 1568821 aatggagttt atgggccctg tacgtttgaa agatgtagaa gaagctcaat caagaattgt 1568881 aagcatcgtc agaaagcttg aagaagccgg tgaaattgta atagcaagag gcggagggga 1568941 tgatattatt gtctaatatc attaaacaag aatcatctat ttctccacaa aaggaaaaaa 1569001 gaaaactttc tatacaagag gtgcgtattg atcattctca ccttttgcag gctgaagaga 1569061 acccggaggc gcttatggcc cgagtgaaag aggaagctga ccggatttct gagcaggcaa 1569121 acagtcatat agaaaatatt cgccgtcaaa ttgaacagga gaaaaacgat tgggcggctg 1569181 aaaaacagaa gcttattgaa gaagcaaaag ccgagggctt tgaacaagga gtagcgctgg 1569241 gcaaagctga ggcaatgaaa cagtatgcag aactgatcgg ccaagcaaac agtataactg 1569301 aaatgtccag aaaagctgtt gaggacaagc ttgaagacgc taatgaagaa atcgttgagc 1569361 ttgccgttgc cctagcaaaa aaagtttggc agcaaaagtc tgatgataaa gaggctttcc 1569421 tcctgcttgt acaacaggtt ataaacgaag tgaaggaata tgacgatata tcaatttatg 1569481 ttgatccata ttactatgag acaatctttc agcaaaaaga tgaaatccag cagcttcttt 1569541 ataaagaatg tcggcttggc atatatgctg atgaaaaagc tcaaaaagga acctgttata 1569601 ttgaaactcc ttttggcagg gtagatgcga gtgttgacac acaattgatg caattgaaag 1569661 ataaacttct gacagcgctg gaagcaggtg cagctgaatg aagacacaga gtctgataga 1569721 ttgtatagaa atgacagact cgtataaacg gtacggaaaa gtcaagcggg taatcggctt 1569781 gatgattgaa tcaaaagggc cagcaagctc aattggtgac ctgtgcctga tttatgcaaa 1569841 aggacagtct gggaaagtca ttaaagctga ggtagtcggc ttccaggaag aaaatatttt 1569901 gcttatgcct tatttagagg ctgcgagcat tgcacctggc agcattgtag aagctactgg 1569961 ggaatcactt cgggttaaag ttgggaccgg actgatcgga caagtcatcg atgcttttgg 1570021 agaaccgctt gacggaaagc ttctgccgaa agggctttcg cctgtatcaa cggagcaatc 1570081 accgcctaac ccgatgaaac ggccgcctat ccgtgaaaag atgggtgttg gagtcagatc 1570141 aattgacagc ttgctgacag tcggtaaagg ccagcggatt ggaatttttg caggaagcgg 1570201 tgtcggaaaa agcaccttaa tggggatgat cgccaagcag acagaggctg acttaaacgt 1570261 cattgcactt gtcggagaac gcggacgaga ggttcgggag tttattgaaa aagatctggg 1570321 gaaagagggg ctgaaacgat cgattgtagt cgttgccacc tcagaccagc cagcattaat 1570381 gagattgaaa gcggcatata cagcgactgc aattgccgag tatttccgag ataaaggcca 1570441 aaatgtcatg tttatgatgg attctgttac aagggtggca atggcgcagc gagagattgg 1570501 actggctgca ggagagcctc cgacgacaaa aggctataca ccttcagtgt tcgctatttt 1570561 acctcgttta ctagaacgaa caggtgcaaa cgagcatgga accattacgg cattttatac 1570621 agtgttggta gatggggatg acatgaatga gccgattgcc gataccgtac gcggaatttt 1570681 agacgggcat attgtgttgg acagggcgct tgccaataaa ggccagtttc ctgcagttaa 1570741 cgtactaaaa agcatcagca gggtgatgtc aaacatttca acaaaacagc atctggatgc 1570801 ggcaaataaa ttccgtgaac ttttatcgac atatcaaaat tcggaagatc tcattaatat 1570861 cggagcttac aaaagaggat catccagaga aattgatgaa gcgatacaat tttatccgca 1570921 gcttattcaa tttttaaagc agggaacaga cgaaccggct ttattggaag aaagcattgc 1570981 tgcattaact agtttgacag gaaatgagga ataaacgtgg cttatcaatt tagattccaa 1571041 aagctgctgg aactaaaaga aaatgaaaaa gaccaatcct tatccgaata tcagcaatca 1571101 gtttctgaat ttgaaaacgt tgctgaaaaa ttatatgaga atatgagcaa aaaggaattg 1571161 ctggaacaaa ataaggaaaa gaaattaaaa agcggcatga gtgtacaaga aatgaggcac 1571221 taccaacaat ttgtctcaaa tcttgataat acgatctatc actatcaaaa gcttgtcatt 1571281 atgaaaagaa atcaaatgaa tcaaaaacaa gaaattttga cagagaaaaa cattgaagtg 1571341 aaaaagtttg aaaaaatgcg tgaaaaacag tttaaaatgt ttgctcttga agataaagct 1571401 gcagaaatga aagaaatgga cgatatttcg attaagcagt ttatgattca aggccattag 1571461 gagcgaatgt aatgtccggc aaaaagaaag aatcaggtaa gttccgttcg gttttgctta 1571521 tcattatcct cccgctgatg tttctattaa tcgcaggggg gattgttctt tgggctgctg 1571581 gtatcaatgt cttaaagccg atacaggatg ctgcggcaaa aacgccggtt cttaaagaat 1571641 tggtccctga aaccgaaaat aaaaaaggcg cagcatcaag taaggatagc agtaatacgg 1571701 cagctctgga aaagaccatt aaggatcaaa aaagtgaaat cagtatattg aataaagatt 1571761 tagaaacaag taaatcagaa atcgacaggc tcaatcaaaa gatccgttca cttgaaaaga 1571821 cggctgagga tcaaaaaaag tcatcagaag atcatactga aggatcagca gactcgaaag 1571881 cttcttctga aaatgacaaa gtgatcagtg tgtacaaaag catggacagc ggaaaggctg 1571941 ctaaaattat tgcccaatta aaggagcaag aagcactgaa aatattgaat ggcctaagca 1572001 aaaagcagct tgctgacata ttggcgaaaa tgactcctga gcaagcagca acctatacag 1572061 aaaaaattgc tgccagccaa gaataggggg aatgaaaggt gaagctgctt gaattagccg 1572121 gacctttgct gcaaaccaca acgggttctg ccgctaaaaa catgaaaagt agccagggag 1572181 tttttcaaaa ctggcttatg tctgaggctg gattgaagga actttcagaa caaggaaagg 1572241 gaactcctaa ttctgaagat cagcttttag cagatgcgct taaaaagatc ggtgaatggc 1572301 taaatgcaag tcctgaagat caagacaaac aaaatgcgga tcttttgcaa acattaagca 1572361 aactgacagg gaagcaattg gatgcgaatg ctctgcaaat gttgcaaaat cttttgcaag 1572421 cagttgaatc aaaaatgtca ggcgggacgg atcaattgct cacagaaacg gagaaaatct 1572481 tttcagaagc taaaacggct ctgagtgcca atgattctgc ttctgacatt aatggagcac 1572541 tgaagtctga taaagagcaa tcaaatcagg aaaatgaagt atccgagcct gcaaaagagc 1572601 ttatctatat ccagatgttc attagccagc tcgtagaagg gaataagctg actgatctcg 1572661 ggaatggcaa tgaagctcat gccatttacc aaaatggaga tcaattcctt tctgcattag 1572721 aaaagaaggg tgtatctcaa caactaattc aggatcttaa acagcaaata ttcactaaag 1572781 ctgagtcaag ttcaaaactt tactcgatga cagcgtcaga gctgaaaagt tttcaaagct 1572841 taatggatca aatgtctatg cttcctcaaa aagggaccaa agaatggagt ttagctgaaa 1572901 gccagctgaa agccttcttg ttatcgaaat catccgaatc atcacaagac tttgggaaga 1572961 gtgttctcac accgctctcg cagagttcat ccagcaaaaa tgcatcggat gtttctggaa 1573021 gtattcagcc tgtagatagt aaatcaggac tccaaatgct gttttcgggg tatcggggca 1573081 taggaggagt tcaaacactt gatctgcagc agatgtcatc tgatatacca aatgccgaaa 1573141 caaaaacggt ggctgatcaa gtgattaatg cgtggaagca gatgaaatat acgcctttcg 1573201 gcagatcgac gggaagtttc actattcggc tgaaccctga acatttagga tttgtcacaa 1573261 tcaagctgac aaatgaaaat ggaatgtttc agagtaaaat catagcatct agccaatcag 1573321 caaaagaatt gcttgaacag catcttcctc agctgaagca atcattgccg aatatggccg 1573381 tccaaattga ccgttttact cttccggtcc aaagcgggga tcagccgata tacggccagc 1573441 ttgctgatga acagaaacag cagcaagagg ggcagagaca gcaaagacag aaaaagcaat 1573501 caaatgattt tggcgatctg ctcgatgaag tgtcgatggt tgaaatggag gaagaagaat 1573561 gacttctata agttcagaat ataaactgcc tgaaaaaacg aacactgtgt cgacgaacaa 1573621 cagcagcttg gggaaagacg agtttttaaa aatattaatg actcaagttc aaaaccaaga 1573681 tccgcttaac ccgattgacg ataaagaatt tatcagccag atggcgactt tttcaagctt 1573741 ggagcaaatg atgaatctga atacgacaat gactcaattc gttgaaaacc aagatccgtt 1573801 tacaacgtat gttgattgga tgggaaaaga agtatcttgg actgatggta aaagtgcaac 1573861 agataaaaca ggcacagtaa gctctgttaa acattttaaa ggaaattatt atctcgttct 1573921 tgatgatggg accgagatca gtcctgcgaa tgtcatgtct gtgggacaat catctaaata 1573981 aaaacatctg ggggaatata ttatgttacg ttcactttat tctggaatca gcggtatgaa 1574041 aaactttcaa acaaagcttg acgtaatcgg taacaacatt gccaacgtaa atacagtagg 1574101 attcaaaaag agccgtgtga cctttaaaga tatggtaagc caaacgattg ccggcggttc 1574161 tgctgctggt gcaacaatcg gcggaacaaa ctctaagcaa atcggtttag gttcatcatc 1574221 tggcacaatt gatacaattc attcaacaag cgcgacacaa agcacaggaa gaacacttga 1574281 tttagcaatt gacggcgacg gttacttccg aattgataca ggtgacggga cagcttatac 1574341 aagagcaggg aacttctatt tagataatac tggaacactg gttacaggtg atggctacca 1574401 tgtactaaat atgaatggcg gaacaattaa aattcctact gatgctcaaa gctttagcat 1574461 tggttctgat ggaaaggtgt caattgttga tgctgagggg aaaacacaag acgggggaca 1574521 aatcgggatt gttacttttg ccaacagtga tggattggat aaaatcggaa gcaacctata 1574581 ccgtgaatct ttaaactctg gaacggccag tgcagcgaac cagcctggtg acggcggaac 1574641 tggtgctctt aaatcaggat ttctcgaaat gtctaacgtc gatttaactg acgaatttac 1574701 tgaaatgatc gtagcccagc gcggattcca atcaaactca aaaattatta caacatctga 1574761 tgaaatcctt caagaactgg ttaaccttaa acgttaagga gggaggggag gcgagtaatc 1574821 gcttctccgc tgttttatga ttaaagtaac ccgtttgaac gggcagccct ttacactgaa 1574881 tgcgctattt attgaacaga ttgaatgttt tccggatact acaattactc tgtcaaatgg 1574941 taagaagttt gtagtaaaag aagatgaaga agctgttctg gaaaagatcg cagctttcta 1575001 ccgaaaaata caaatatttg caatggatca aggaatagag gaaccggaat gaagaaaaag 1575061 ttaatgatca tattactaat tattcttatc gtaattggtg ctctcggggc ggcggcttat 1575121 tttgttttag gcggaaagtc cgaaaaaagt gaagcgaaaa aaagtattga tgaaatcgtt 1575181 gcgtcttctg ttgatgtaga agagatcaca acaaatttaa agtctgataa cattatccgt 1575241 cttgctatta aacttgaaac tgattctgat aaatcaaaag aagaacttga gaaacgtgat 1575301 ttccaagtga aagacgctgt tatatcactg ctggctgata cgaatgctga tcagattgag 1575361 ggagacaagg gaaaagaaac ctttaagaag gaactaaaag ataaaataaa tagctacctc 1575421 caagaaggaa aagtagaaaa agtgtatatt acctccttta atctgcaata aagcataatt 1575481 tgacagaata cggaggtgag gaaaatgtca ggagaagttc tctcccaaaa tgaaatagat 1575541 gcactgctct ctgcaatatc aactggtgaa atggacgctg aagagctgaa aaaagaagaa 1575601 aaagagaaga aagtcaaggt ttatgatttc aaacgtgcgc tgcggttttc taaggatcag 1575661 atccgcagtt taacgagaat tcatgacaat tttgcaagac ttcttaccac tcatttttct 1575721 gctcagctca gaacctatat tcacatatct gtcagttctg ttgatcaggt tccgtatgag 1575781 gaatttatca gatcgattcc aaacatgacg attctgaatc tatttgatgt tcatccgatg 1575841 gaaggaagaa ttatgatgga ggtcaacccc acgatagctt atacgatgat ggatcgagtc 1575901 atgggcggga ttggaatcag tcataacaag gttgacagtt tgacagaaat tgaaacaaaa 1575961 atcatttcta atttatttga aaatgcactg ggtaattata aagaagcttg gcagtcaatt 1576021 gctgatattg aaccggaaat gactgagttt gaagtgaatc cgcaatttgt tcagatggta 1576081 tctcctaatg aaacagtcgt ggtgatctcg ctcaatactc aaattggtga aatcagcggt 1576141 gtcattaatc tctgtatccc gcatattgta ctcgagccgc tcataccgaa gctttcagtc 1576201 cactattgga tgcaatcaga ccgaaatgag ccaaagcctg aggaaacaaa gtcgcttgaa 1576261 aaacgtatca tgacagcaca aatacctgtc gtggccgagc tcggcacatc tgaactgacg 1576321 atagaagagt ttttaagttt agaagtcgga gactgcataa ctttggacaa atcagtcacg 1576381 gatcctctta ctgtattggt cggagataag ccgaaatttt taggacaagc cggccgggtg 1576441 aatcgaaaac aggcagtgca aattttagat cacgacataa gaggtgaaca agatggagaa 1576501 taatagatta tctcaagatg agattgacgc gcttcttaac ggtactggca gcacgcttga 1576561 tgagccagag attccggaag tagatgactt atcggaaatg gagcgtgatg cgatcggtga 1576621 aatcggtaat atttcattcg gcagttctgc gacagcactg tcaacgcttt taaatcaaaa 1576681 ggtcgatatt acgactccaa gcgtaacggt cattccaaga agtaaaatca gcgatgcgtt 1576741 tcctgaaccg tatgtagcga ttgaagtgaa ttatacggag ggcttcagcg gaagcaacct 1576801 gttagtcgtg gaacaaagtg acgcggcgat cattgcggac ttaatgatcg ggggagacgg 1576861 aaaaggtgcg gacccttcac tgggtgaaat ccatttaagt gcggttcaag aagcaatgaa 1576921 ccaaatgatg ggatcggctg ccacatcaat gtctactgta ttcagtaaaa aaattgatat 1576981 ttcacctcct cgggttgaat tgctggatgt tactgaagaa aagggtacag accgtattcc 1577041 tgatgatgaa atgctggtga aagtttcttt caacttaaag gtgggagaat taatagactc 1577101 cagcattatg caactttacc cattgacatt tgcgaaagat ttaatttcaa gccttatgaa 1577161 ctcagaaagt gcagaggaag aagaaacggt gcagcctgaa gttacatacg aacagccgaa 1577221 agagcctgtg acgccagagc cgcgtattga accgaagcaa cagcagcagc cgccaaaaag 1577281 gcagggaaca gcaaaaaaag cagcgccagt tcaggtttca ccggtggaat tttccgcgtt 1577341 tgatccaaac gaagctgtac aagcccctat tcataatctg gatatgcttt tggatatccc 1577401 gctttcgatt actgttgagc ttggcagaac gaagagaagc gtaaaagaga ttttagagct 1577461 ttctgccgga agtattatcg agcttgataa attagccggt gagcctgtag atattttagt 1577521 taatcagcgt atcgttgcca aaggcgaggt cgttgtcatt gaagaaaact tcggagtgag 1577581 agtcactgac attttaagcc aggcagagcg cattaataat ttaaaataac gaaacacaag 1577641 gagagagata gattatggca catagaattt taattgtaga tgacgcagca tttatgcgaa 1577701 tgatgattaa agatattttg gttaaaaatg gttttgaagt tgtggcggaa gctgaaaatg 1577761 gagcacaagc ggtagagaaa tataaagagc attcacctga ccttgttact atggatatca 1577821 cgatgccaga aatggatggt attacagcat taaaagaaat taaacaaatt gatgcgcagg 1577881 caagaatcat catgtgttct gctatgggac agcaatcaat ggttattgat gccattcagg 1577941 ccggcgctaa ggatttcatt gtgaaacctt tccaggctga ccgtgtgctt gaagcaatca 1578001 acaaaacatt aaattaaagg gtgtacgact gttgaaaaag agtcaatatt ttattgtttt 1578061 tatttgtttt ttcgttttat tcagtgtaca tccgattgct gctgccgcgg cagactctga 1578121 taattcaact gtaaacgaat ggtttcaaaa gaaagatgaa aaaactgcag atcaatcaga 1578181 gcaaaagaaa gaaaaaacaa caaaaactgc tgatgagacg gagggagcgg ctgctccttc 1578241 tgtctcagct tttgattttg taaagatgat tttcgcttta ctgtttgtta tcgtgctgat 1578301 ttacgggctg gttaagctca tgaacaaaag aaatcggctc ctaaagcctt ttcaatatgt 1578361 tgaaaatatt ggcggcacat cggtcggtca gaacagatcc atacaattga tcaaggtcgg 1578421 gaaaagtgtg ctcgtcgtcg gtgtaggaga gacgatccag ctgctgaaag aaattgagga 1578481 tgaaaaagag attgaagtca ttctcagtca gcatgaagag gcaatgtcaa gcaaaataga 1578541 gtggcaaaag tttgtgaagc cgcttaagag ttctgaacat cagccgcagc aaaaactgcc 1578601 ttcattttca aaagcattaa aagagcaact tgaagagtta aaacaaaacc gttctgaagg 1578661 aaagaagaaa ggcccacgtc atcatgaatg agtttataaa tattttcagt tcaagcgatc 1578721 cggaaaacgt aagttcgact gttaaattac tattattgtt aactgtattt tcagtggcgc 1578781 ctggaatatt gattcttatg acttgtttta ctcgcatcgt cattgttctg tcatttgtca 1578841 gaacttcact tgcgacgcaa tctatgcccc caaaccaggt tctaatcggg cttgcgctgt 1578901 ttttaacatt ttttattatg gctcctactt tttcagaaat taataaagaa gcgctgaccc 1578961 cattaatgga caacaaaatc agcttggatg aagcgtatac gaaagctgag gaaccgatta 1579021 aagaatttat gagtaaacac acaaggcaga aggatctggc gctgtttatg aattacgcga 1579081 aaatggataa acctgaatca ttaaaggata ttccgttaac aacaatggtt ccggcttttg 1579141 ccatatcgga gcttaaaaca gcatttcaaa taggttttat gatttttatc ccttttttaa 1579201 ttatagatat ggtagtggcg agcgtcttga tgtcaatggg aatgatgatg ctgcctccag 1579261 ttatgatttc tctgcccttt aaaatattac tttttgtttt ggtagacggc tggtatttaa 1579321 ttgtgaaatc tttgcttcag agcttttagg gtaggtgcta aacgtgagtt cagaatttgt 1579381 aatttctatg gcggaaaaag ccgtatacgt aacgctgatg atcagcgggc cattattggc 1579441 tattgcttta ctggtcggtt taattgtcag catatttcag gcgacaactc aaatccagga 1579501 acagactttg gcgtttattc cgaaaatcgt ggcggttctc ctggctctca ttttttttgg 1579561 tccgtggatg ctgtcgacga ttctttcatt tacaacagag ctgttttcta atttaaatcg 1579621 ttttgcaggg taatgtagag atgaattcaa ttattgactt atttcctgct tttttattgg 1579681 tttttattag aatctctgct ttttttgtaa cgattccgct atttggacat cgaaatgtgc 1579741 cagctgttca tcgcataggt tttgcttttt ttcttgcggt catttgtttc agcaccattg 1579801 ataaaccgcc ctctttggag atagatgagc actatatgct tttggcgttt aaagaagctt 1579861 tggtcggcct atgtctgggt ttaattgctt atatgatgat tgccgcagtg cagattgccg 1579921 gctcgtttat tgattttcaa atgggatttt caatagcaaa cgttattgat ccgcaaaccg 1579981 gtgcacaaag tccgttgatt ggccagttta tctatacgat ggcacttttg tttatgctga 1580041 gtgtcaatgc ccaccatttg ttgctggatg gtatttacta cagctttcag tatatttcag 1580101 ttgatcaggc atttccgaat ttcggcgatg aaaagtttgc ctattttatt gcgaaaagct 1580161 ttaatgcaat gtttattatc gcttttcaaa tgtcagcgcc ggttgtggcc agtttgtttc 1580221 tagttgattt agcattaggt atcgtggctc gaactgttcc gcagttaaat gtatttgtgg 1580281 tcggtctgcc tttaaagatc gctgtcagtt tcattatgct cattgtatgt atgtccgtta 1580341 tcttcgtcgt tgtccggaat gttttcagtt taacgattga aacgatgcgg aatcttttag 1580401 cattggtcgg tgtttcttaa tgaagcttag agttgacctg cagttttttg cgggagagaa 1580461 gacagaaaaa gccactccga aaaaacggaa ggatacgcga aaaaaagggc aggtagccaa 1580521 aagctcggat gtcaataccg ccgtttcttt actggtaata ttcctttcgc ttattgcaat 1580581 tggtccgtat atgagagaca ggctgctgtc attcatagaa acattttata ccgaatcgct 1580641 cacaatgaag ctctcagaat caaatgtgca tacattgttt gtcagcttat taaaggatat 1580701 gggcatgata ctcgcaccga tcttgcttgt tgctcttgtt gcaggagtcg taagcaacta 1580761 tatgcaggtt gggttcttgt tttctgctga agtgatacag cctaagcttg aaaaactgga 1580821 tccgatcaaa ggctttaaac gaatatacag tatgagggcg attgtagagc tgattaaatc 1580881 aattttgaaa atcgtagtcg tcggttttgc ggcttttgct gtgctttggc tgcattatgg 1580941 agaaattctc cggcttcctc tcctgacacc cgaagaggca ctttctttcg tttcaaaact 1581001 cactttgtgg atgggactaa gcggtgcagg tgcattgttg attcttgctg gtctcgacta 1581061 tttatatcag agatttgact atgagaaaaa tatcaaaatg tcaaaacaag atataaaaga 1581121 tgagtacaaa aaatctgaag gagacccgat tatcaagtct aaaattaaac aaagacagcg 1581181 ggaaatggcg atgaggcgga tgatgcagga agttccaaaa gcagatgtca ttatcacaaa 1581241 cccgactcac tatgcgattg ctttgaaata tgatgaagaa aaaatggacg caccttatat 1581301 tgttgcaaaa ggcgtcgacc accttgcgtt aaaaatcagg aaaattgcta aagagcatga 1581361 tgtcatgatg gtagaaaaca gaccgcttgc ccgtgcgtta tatgatcaag tggaaattga 1581421 ccaggcagtg ccggaagaat tttttaaagt tttagcagaa attctggctt acgtatataa 1581481 aacaaaacaa aaagtatatt gaatttttcg atttaaaagg agagaaaaaa cagcatgtca 1581541 acaagagatt tatccgtttt aataagtgtt gtcctcattg tggcgatgct ggtgattcca 1581601 tttcctccat ggctgttaag tattttgatc attattaata tttctcttgc gttgatcgtg 1581661 cttctcacca caatgaatat gcaggaagcg cttcagtttt cgatttttcc gtcactgttg 1581721 ctgcttttga ccctatttcg tttgggcttg aacgtctcaa ctacccgttc aattctttca 1581781 cacggtgagg gaggtaaagt cgtcgagact ttcggaaatt tcgttgtcgg cggaaatgta 1581841 ttagttggac tcgttgtatt tatcatcctt attattattc agtttatcgt cattacaaaa 1581901 ggtgctgaac gtgtttccga ggttgcagca aggtttacgc tggacgcaat gccggggaag 1581961 cagatgagta ttgatgctga tttaaacgca gggatgatta ccgaacagga agcgaagcat 1582021 cgccgcgaaa aagtggcaag agaagcagac ttttatggag caatggacgg tgccagtaaa 1582081 tttgtaaaag gtgacgccat tgccggaatc atcattgtga tgatcaatat tattttcgga 1582141 atcgtgatcg gaatgcttca gcagggcatg tccattcaag aagctgcttc acactttacg 1582201 atgctgactg taggggatgg aattgtttcg caaatcccgg cactgttaat ttctacggct 1582261 acgggtattg tggtcacaag agctgcatct gaaggaaact tagggcatga cattacaggc 1582321 cagctgtttg cgtatccaaa gcttttatac gtcgcagcag ctacgatcat gcttttaggt 1582381 attttcactc cgatcggcat ccttctgacg gggccgcttg cgggattgct tgcttttggc 1582441 gcatatacac tatctaaatc aggtaaggaa aaagaagaag tggatgagat tcttgaggaa 1582501 gaggctgagg tggacgagct taaaagccct gaaagtgttg ttcagcttct gcatatagat 1582561 ccgatagaat ttgagtttgg atatggcctg ataccgcttg ctgatgccaa tcaaggcggt 1582621 gatttattag accgaattgt tatgatacgc cgtcagttgg ctttggaact cgggcttgtc 1582681 attcctgtcg tgcgaatcag agataatata gcgttgcagc ctaatgaata ccgattgaaa 1582741 attaaaggaa acgaagtagc aaaaggcgag ctgttgcttg atcattattt agcgatgtcg 1582801 cctactcctg aggacgatct cattgaaggg attgaaacag tggagccttc attcggactg 1582861 ccggctaaat ggattagcga agcggtaaag gatgaagccg acatgcttgg ttatacagta 1582921 gttgatcctg catcagtcgt ttcaacgcat attacggaga aaattaagca gcatgcccac 1582981 gaattgatcg gaaggcagga gacaaaacag ctgatcgatc acttgaaaga atcgtatcca 1583041 gtcctggttg aagaggttac gccgaatcca ttgtctgtcg gtgatattca gaaagtgctt 1583101 gctaagcttt taaaagaaaa agtttcaatt cgaaacttag taacgatttt tgaaacactt 1583161 gctgactatg ggaaattaac aacagattct gatctcttga cagagtatac aagacaagcg 1583221 cttgctaaac aaattacagc ccagtttgcc aaagaaaatg aagtgttgaa ggttgttact 1583281 tgttccggcc gtgtagaaaa agcaatagca gacggtgtgc agcagacgga acacgggaac 1583341 tatttatcac ttgaaccaga tatttcagaa agtatagtgc gctctgtcgc caaagaagct 1583401 gaacagctct cattacgtca ggaaaccgcg attcttcttt gctcgccgcc tgtcagaatg 1583461 tatgtgaagc agctactgga acggtacttc cctgatcttc cggtactctc ttataacgaa 1583521 cttgaggcga atgttgaggt acaaagcatt ggagtggtgg atatttaatg aaaataaaaa 1583581 aatttactgc tgcttcaatg caagaagcgg cacttctcat cagaaaagag ttaggtaatg 1583641 aagcggtcat attaaattcg aaaaaaatta aaaagcgaaa atggtttggc ctcgtcaaca 1583701 agcctgctgt tgaagtaatc gccgtattgg atcaggactt tcttgagaaa aaaacgcctc 1583761 agaaggcagc tgaaccgaaa caaacattaa aaactccggt cagcagtcca aaaatagagg 1583821 agagaacata tccccctcaa attccggcgc aacaggagct aggtgatttt tcagcatatc 1583881 aatctgtact tcctgagccg ctgcgaaaag cagaaaagct tttgcaagaa acagggatca 1583941 aagagtctac gaaaacgaac actctgaaaa aattgcttcg cttctctgtt gaagcaggcg 1584001 gcttgactga agaaaatgtt gtcggcaaac ttcaggaaat actatgcgat atgctgccct 1584061 cagcagacaa gtggcaggag ccaattcatt caaaatatat cgttctcttt ggttcaacag 1584121 gggctggtaa aacaactaca ctggctaaac tcgcagccat atctatgctt gaaaaacata 1584181 aaaaaatcgc ttttattaca acagatacgt atcgtattgc agctgttgaa cagttgaaaa 1584241 catacgctga actgctgcag gctcctctgg aagtttgcta tacaaaagaa gaatttcagc 1584301 aggcgaagga gctattttct gagtatgatc atgtgtttgt tgatacagct ggaagaaact 1584361 tcaaagaccc gcaatacatt gatgaactga aagaaacgat tccttttgag agcagcattc 1584421 agtcatttct tgttttatcc gcgactgcaa aatatgaaga tatgaagcat attgtcaaac 1584481 ggttttcatc cgtccctgtc aatcagtata tttttacgaa aatagatgaa acgacttcct 1584541 taggttctgt atttaatata ctggcagaat caaaaatagg tgtcgggttt atgactaacg 1584601 gccagaatgt gcctgaggat atacagactg tatctccact tggttttgtg aggatgctgt 1584661 gcagatgaac agatatgacc aagcagcaac tttacgggcg aaaatggaaa aacgtgagcg 1584721 cgttctgcca atggtttatt cacaaaaagc gaagacactt gctgtcatca gcggcaaggg 1584781 cggtgtcgga aaatccaata ttaccttaaa tatggcactt gcgctgcagg ataaaggtaa 1584841 gaaggtgctg ctcatcgacc ttgatatcgg gatggggaac attgatatat taataggaaa 1584901 ttcatcgtct gccacgataa tcgatgtttt aaccgatcgt aagcctttgc tgcagtcatt 1584961 atccgttggc ccaaagggtt tgcggtatat atcaggggga accggtcttg atgtgatgtt 1585021 tcagctcgat cagagaaaat ggacgttttt tgccaatgaa ctttctcatg cattaagcca 1585081 gttcgattat gtgctgtttg acatgggagc aggcttatca aaagatcaac tgccttttat 1585141 tttatcagca gaagatattt tgattattac aactcccgag ccgacggcca ttatggacgc 1585201 atacagcgct gtcaagcact tggttttgac agaaaataag ctttcaatga aggtggctgt 1585261 caatcggtgc cgtgaccaaa aggaagggct tgacgctttt gcccgcctct cccgtacaat 1585321 tcatatgttt ttggatgttc aggttcagtt tgccggttcc gtttctgacg atgtgatcgt 1585381 gagcaaagcg gttgtcgaac aggttccttt tttcataaaa agccctcagg caaaagccag 1585441 ccggtcagtc cgtattttag cggacgcctt gtttgaaaga gaagaaacga gacacaaaga 1585501 agacaaacag acatttattg agaaattatc ttctttttta atgaggaggg cttaatttga 1585561 ttcgtgtgct tgtagttgat gattcagctt ttatgagaaa aatgataagt gattttctga 1585621 ccgaagaaaa gcagatagaa gtaatcggaa ctgcgagaaa cggagaagaa gcgcttaaga 1585681 agattgaatt attaaaaccg gatgttatta ctcttgatgt tgaaatgccg gtcatgaatg 1585741 ggacagatac gctccgcaaa attattgaga tttataactt gccggtcatt atggtgtcta 1585801 gccagaccga gaaaggtaaa gaatgcacaa ttaattgttt ggagatcggt gcctttgact 1585861 ttatcacaaa gccatcaggc tcaatatctc tggatctata caaaattaaa gaacaactag 1585921 ttgagcgtgt cgtcgcggca ggactttccg gcaagcggaa acgtcctgtt tcccagacag 1585981 ttcggcccga acctattgtg cgtgctgtcg ttaagcctga attaagcaaa ccgaaacctg 1586041 gcacgggcag acaaattgtg tgtatcggca catcaacagg cggtccacgg gcgttacaaa 1586101 aggtgatacc gaagctccct aaggatttga acgcaccagt ggttgtcgtt cagcacatgc 1586161 ctgaagggtt tactgcttct ttggctgatc ggctgaatca tttatctgac attcaggtaa 1586221 aagaagcaaa agatggtgaa gcagctctta acggctgtgt ttacatagca ccgggcggaa 1586281 aaaacatatc cgttattaaa aacagcgaag gactccaggt tgtgcttgat aaccatgaca 1586341 caccaagccg tcataaacca tctgctgatt atttattccg ttctgtcggg aaactgacag 1586401 attatgaaaa agtagcggtt atcatgaccg gaatgggcag tgacggcact gctggactaa 1586461 aggacatgct aacagccggc aatgtgaaag ccattgcgga gtctgaagaa tcttgtgtcg 1586521 tatacgggat gccaaaagct gctgttaaag cgggtctcat tcatgagatt aaacatgtgg 1586581 aagatatcgc agcatccatc acaagctgtg tgaaaaaaga gagggtgtga ttcaaatgga 1586641 tatgaatcag tatttagatg tctttattga tgagagtaaa gaacatttac aaacatgtaa 1586701 tgaaaagctt cttcttttag agaaagaccc gactgatctt cagctcgtac atgatatatt 1586761 cagggctgcc catacattaa aaggaatgag cgcaacgatg ggctacacgg atttagcaca 1586821 tcttacccat ctgcttgaaa acgtgctgga tgcaatccga aacggagaca tggaagtcac 1586881 ctcagactgg ctggatattt tgtttgaagc tctggatcac ctggaaacaa tggttcagtc 1586941 tattattgat ggcggggatg gtaaaagaga tatctcagaa gtgagtgcca agcttgatgt 1587001 gaatggtgcg cacgctgaat ccgctgcctc cgctgaacct gcagaagcac agagttcagc 1587061 atctgattgg gaatatgatg aatttgaacg cacagttata caagaagcgg aggagcaagg 1587121 cttcaaacga tatgaaatca agatttctct gaacgaaaac tgtatgttaa aagcagttcg 1587181 tgtctatatg gtgtttgaaa aactaaatga agtcggagaa gtagccaaaa caattccaag 1587241 tgctgaagtg cttgaaacag aagattttgg aactgacttt caagtttgtt tcttaacaca 1587301 tcaatcagcg gaagacattg aacaattaat caatggcgtg tcggaaattg agcatgttga 1587361 agtcattcaa ggggctcctt taacatcagc tgaaaagcct gaagaatcta agcaagaaga 1587421 ttcaccagca gcagctgtac ctgcgaagca ggagaaacaa aaacagcctg ctaaaaacga 1587481 tgaacaggcg aagcattcag ccggcggatc taaaacaatt cgtgtcaaca ttgacaggct 1587541 tgattcttta atgaacttat ttgaagagct tgtcattgac cgcgggcgtc tcgagcagat 1587601 tgcgaaagag cttgagcata atgaactgac tgaaacggtt gaacgaatga cgagaatttc 1587661 cggagatttg caatcgatta ttctgaatat gagaatggtc ccggttgaaa ctgtttttaa 1587721 cagattcccg agaatgattc gccagcttca gaaagagctg aataaaaaaa ttgaactctc 1587781 gatcatcggt gcggaaactg aactggatcg tacagtaatt gatgaaatcg gagatccact 1587841 cgttcacttg atcagaaaca gtattgacca tggtatcgag gcgccggaaa cacgtttgca 1587901 aaagggaaaa ccggaatcag gaaaagttgt gcttaaagct tatcacagcg gcaaccatgt 1587961 ctttatcgaa gtagaggatg acggcgcagg ccttaatcga aaaaaaattc tggaaaaagc 1588021 gcttgagcgc ggggtcataa cggaaaaaga agctgaaacc ttagaagaca accaaattta 1588081 cgaattgatt tttgctccgg ggttctcaac tgctgaccaa atttctgata tttccggccg 1588141 cggtgtagga cttgacgttg taaaaaacaa actggagtct cttggcggtt cagtcagtgt 1588201 gaaatcagcc gagggtcaag gctctctatt cagcatccag ctgccgctta ccttgtctat 1588261 tatttcagtt ctgctgatta agttggaaga agagacattt gccattccga tttcttcaat 1588321 cattgagaca gcagttattg acagaaaaga cattttgcaa acgcatgacc gtgaagtgat 1588381 tgactttaga gggcatattg tccctgtcgt ttatttaaaa gaagagttta aaatagaaga 1588441 tacaagaaaa gatgcggaac agctccatat cattgtcgtg aaaaaaggcg acaaacctac 1588501 tgcatttgtg gtggactcct ttattggcca gcaggaagtt gtgctgaaat cactcggaga 1588561 ttatttaaca aacgtctttg caatttccgg agctactatt ttaggagacg gagaagtagc 1588621 gctcattatt gattgtaatg cactgattat ttaaccattc gaggaggtgt ctcacatgac 1588681 tgcagaaatt aaaacaggcg aaaaaatgat agtctttatg gtaaatggca aagaatatgc 1588741 catttccgtc actcaggtga aatcaattga aaaatggcaa aagccaacga gggtacctgg 1588801 cgtcgaacca tatatttgcg gggtaatcaa tttacgcggg gtggtgactc cggttattga 1588861 tttaagaaaa cgcctgaatt tgccagagta tgaaattaca gatgaaacac gaattatcat 1588921 tattgcttat cgtgatattg aagtcggctg gattgtggat gaagcgaatg atgtgattac 1588981 cgtacacgaa agtgaaatag aatctgctcc agaaggcgtt cagaaagata cggatgtgtc 1589041 gatcgaacag attgtgaaac aagagaacag actcttaaat attattgatg cgaacgcggt 1589101 tttggataaa gaatcatctc agtccgctgt gcccgatcaa gcttaatctt aaaggggtta 1589161 tgacatgagt atttttaatg gaatcaaaga agagcagatg gacattttgc gggaagtcgg 1589221 caatataggc gccggccact ccgcctctgc aatggcccag ctgttaaata gaaagataga 1589281 tatggaagtc ccatttgcaa agctgctgtc ttttgatgag cttgttgatt ttttcggcgg 1589341 cgccgatgtc ccggttgcca gcatcttttt aagaatggaa ggcgatttaa cgggttcaat 1589401 gttctttata atgccttttt ttcaggcgga gcagtttatc agagagctga ttggaaaccc 1589461 cgattttgac atagaggact taggtgaaga ccacatgagc tcatccgctt tgcatgaact 1589521 gggcaatatt ttagcggggt catatttaac agctttggcg gatttgacga aactccagct 1589581 ctatccaagt gttcctgaag tctcattgga catgttcgga gctgtgatca gcgaagggct 1589641 gatggagctc agtcaggttg gagaacacgc cattgttgtc gacacgtcaa tttttgacca 1589701 aagccatcag caggagctga aagcgcatat gtttatgctg ccggactatg attcatttga 1589761 aaagctcttt gtcgccttag gtgcatcatt atgagtacaa ctgaggctgt tgttataaag 1589821 gttgggattg ctgacgtgaa gatcgcccgc ttcccggata ccatccggac ctctggtttg 1589881 ggctcatgtg tggggctggt gctttatgat aaagaaaagc aaacggcggg tcttgttcat 1589941 gtcatgcttc cggattcgac gttatcgaaa actgccgagc tcaaccgggc taagtacgct 1590001 gacaccgccg tacagaccac gattgatatg ctgatagaag cgggatgccg gaaatttgca 1590061 ttaaaagcaa agctggccgg cggatcagag atgtttaaat ttaaatcgac aaatgatttg 1590121 atgaagatcg gaccgagaaa tgtattagcg ataaaagaac agctgtcttt atttaatatt 1590181 cctattatta gtgaagatac gggcggctca agcggccgga cgatagaatt tgaaccgaag 1590241 tcctgcatgc tgcatattcg aactgttaaa caaggtgaaa aaacgattta attaaggtat 1590301 tagggggata acaatgcaat ccttgaatta tgaagatcag gtgctttgga cgcgctggaa 1590361 agagtggaaa gatcctaaag ccggtgacga cttaatgcgc cgttacatgc cgcttgtcac 1590421 atatcatgta ggcagaattt ctgtcggact gccgaaatca gtgcataaag acgatcttat 1590481 gagccttggt atgcttggtt tatatgatgc ccttgaaaaa tttgacccca gccgggactt 1590541 aaaatttgat acctacgcct cgtttagaat tcgcggcgca atcatagacg ggcttcgtaa 1590601 agaagattgg ctgcccagaa cctcgcgcga aaaaacaaaa aaggttgaag cagcaattga 1590661 aaagcttgaa cagcggtatc ttcggaatgt atcgcccgcg gaaattgcag aggaactcgg 1590721 aatgacggta caggatgtcg tgtcaacaat gaatgaaggt ttttttgcaa atctgctgtc 1590781 aattgatgaa aagctccatg atcaagatga cggggaaaac attcaagtca tgatcagaga 1590841 tgacaaaaat gttccgcctg aagaaaagat tatgaaggat gaactgattg cacagcttgc 1590901 ggaaaaaatt cacgaactct ctgaaaaaga acagctggtt gtcagtttgt tctacaaaga 1590961 ggagttgaca ctgacagaaa tcggacaagt attaaatctt tctacgtccc gcatatctca 1591021 gatccattca aaggcattat ttaaattaaa gaatctgctg gaaaaagtga tacaataatg 1591081 aatttcatgg ttagcgagtg aaaaacatgt caacactatt atggctttta agctttatgc 1591141 tccacggcgt tcttctgtac gctgtcatta tcctgtatac gaggctcgct gcagtgaaag 1591201 aaacagaaaa acagcaaaaa cagatacttg aagagacgga aaacaccttg gcggcatttc 1591261 tgcttgaatt aaaagaagaa aatgagaaac tgatagaaaa taaagcttca tctgcaagtc 1591321 aatcagatga agaatcccaa aagtcaggcc ttcagacctc tgaaacatat caagagcggg 1591381 atccagtcca agaggcagag aatcttcctg aacatattga aggtctgatt acagaggttg 1591441 accgtcggga agagctcgta aacagtgagg tccaatcatt tgaagaccag gtcatagaat 1591501 tatatgaaca gggatattcg gcaagtcaaa ttgcccagaa aatgaagagc ggaaagacag 1591561 aaatcgagct atttttaaaa tttcgctcca aaggtgtaaa ggattcttga ttgtcggata 1591621 aagctgtgtt atattatgtc ttggtgttaa atacacacgc ttaacgattt atgcagaggg 1591681 tgctgcaggc ggcagttctg tacaaaaatg acctaagcgg aggaaaaaaa ccattatatt 1591741 aggaggaaat aacatgtcag tcatttctat gaagcaattg cttgaagctg gtgttcactt 1591801 cggtcaccaa acacgccgtt ggaacccaaa aatgaagcgt tacattttca cggagcgtaa 1591861 cggaatctac atcattgacc ttcaaaaaac agtcaaaaaa gtagaggaag cttacaactt 1591921 cactaaaaat cttgctgctg aaggcggaaa aatccttttc gtcggaacaa aaaaacaagc 1591981 tcaagattct gttaaagaag aagctcaacg ctctggcatg tactatgtca accaacgctg 1592041 gttgggcggt acattaacaa acttcgaaac aatccaaaaa cgtattaaac gtcttaaaga 1592101 cattgaaaaa atgcaagaaa acggtacgtt tgatgtactt cctaaaaaag aagtcgttca 1592161 attgaaaaaa gaattagagc gtcttgaaaa attcctaggc ggaattaaag atatgaagga 1592221 tcttcctgat gcattattca tcatcgatcc tcgcaaagag cgcatcgctg ttgcggaagc 1592281 tcgcaaatta aacatcccta tcatcggtat cgtagatact aactgtgatc cagatgaaat 1592341 cgatgttgtt atcccagcga acgatgacgc tatccgcgct gttaaacttc taacttctaa 1592401 aatggcagat gcaatcttag aagcgaagca aggcgaagaa gaagcggaag ttgctgaaga 1592461 aactgcacca gaaacagaaa caacaactgc gtaacctatt caaaaggtga taagagggac 1592521 tgccttttat cacctttttt caagaaaaat gtgtaatata catactcttg tttaaacata 1592581 taaggaggaa tacaaatggc aattactgca cagcaagtaa aagaactgcg tgaaaaaact 1592641 ggcgcgggca tgatggattg taaaaaagcg ttaactgaaa ctgacggaga tatggacaaa 1592701 gcaattgacc ttttaagaga aaaaggaatt gcaaaagcag cgaaaaaagc tgaccgtatc 1592761 gcagcagaag gttctactct tattaaaact gacggcaaca aaggcgttat cctagaagta 1592821 aactctgaaa ctgatttcgt tgcgaaaaac gaaggtttta aagagcttct taacacttta 1592881 gctgaccacc ttcttgcaaa cacgccagct gatgttgaag aagcaatggg ccaaaaaatg 1592941 gaaaatggct caactgttga agagtacatc acaagcgcag ttgctaaaat cggtgagaaa 1593001 atcactcttc gccgctttac agttcttaca aaagacgaca gctctgcatt cggtgcgtac 1593061 cttcacatgg gcggccgcat cggtgtatta actgttctca acggtacaac tgatgaagaa 1593121 actgcgaaag atatcgcaat gcacgttgct gcagttaacc ctcgttacat ttctcgtgat 1593181 caagtatctg aagaagaaac aaatcatgag cgtcaaatct taactcagca agccctccaa 1593241 gaaggcaaac ctgaaaacat cgtagcgaaa atggttgaag gccgtctgaa caaattcttc 1593301 gaagaaattt gtctattaga ccaagcgttc gttaaaaacc cagatgaaaa agtgaaacaa 1593361 gttattgcag cgaaaaacgc tactgttcaa acttttgtcc gctatgaagt tggagaaggc 1593421 atcgaaaaac gtcaagaaaa ctttgctgaa gaagtaatga accaagtgaa aaaataatgg 1593481 tgaaaagatt tcgcggctaa gtcgcgtctt ttcaggcagt ataggggaca cattttgtgt 1593541 tccctatttt taaaactata tttacaaacc tttttttctc ttgcataata gaaaacggca 1593601 atgtttacac ttggaggtta tcatggaaaa accaaaatac aaacgtatcg tattaaagct 1593661 tagcggggaa gcattggcag gagaacaggg aaatggaatt aacccgactg tcattcaatc 1593721 cattgcaaag caagtgaagg aaatcgctga gcttgaagtc gaagtggctg ttgttgtagg 1593781 cggcggcaac ttatggcgcg gaaaaacagg aagtgacctg ggcatggacc gcgcgactgc 1593841 tgactatatg ggaatgctgg cgacagtaat gaattcgctt gctcttcaag acagcttgga 1593901 aacactcgga atccagtcca gagtgcaaac atccattgaa atgagacaag ttgctgaacc 1593961 gtacataaga agaaaagcga tacgccactt agagaaaaaa cgtgtcgtta ttttcgctgc 1594021 gggcacagga aacccatatt tctcaactga tacgacagct gcactgcggg ctgctgaaat 1594081 tgaggcagac gttattttaa tggctaaaaa taacgttgac ggtgtgtata atgctgatcc 1594141 tagaaaagat gaatcagctg ttaagtatga atcactttct tatcttgacg ttcttaaaga 1594201 cggcctggaa gtcatggatt caacagcttc ctctttatgc atggacaatg acattccgct 1594261 tatcgtcttt tctattatgg aagaaggaaa tatcaaacgt gccgttatcg gtgaatcaat 1594321 cggaacgatc gtgaggggga aataacgtgt caaaagaagt attaactcaa acaaaagaaa 1594381 aaatggaaaa agcaattgct gcttatcagc gcgaattggc tactgtacgc gcaggccgtg 1594441 caaatccatc attattagat aaagtaacgg ttgaatatta cggagcgcag acacctttaa 1594501 atcagttgtc ttctattaac gtgcctgaag ctcgtatgct cgttatcacg ccatacgata 1594561 aaacagcaat cggtgatatc gaaaaagcga ttttaaaagc tgatttaggt cttacaccaa 1594621 caagtgacgg caatatgatt cgaattgcaa ttccggcact aacagaagag agacggaaag 1594681 aattagtgaa agttgtaaaa aaatatgctg aagaagcaaa agtagctgtt cgtaacgttc 1594741 gccgtgatgc taacgatgat ctcaaaaaac ttgagaaaaa cggagacatt actgaggatg 1594801 aactgcgtgc ttccactgaa gacgttcaaa aactgacaga tgaatatgtg tcaaaaattg 1594861 acagtgtcac aaaagacaaa gaaaaagaaa tcatggaagt ttaatgaaaa actatgtaca 1594921 atagataata gtgaaaagac cctctcatgt ttacaggggg tttttttgtt aatactgttg 1594981 attacattga ttatcagcag ggaatgtaac ctttttgggt gacggaggaa tctcatgctc 1595041 aacatactca aaaattggaa gaatcagcaa actgcggctt ccaacttaga acgttataca 1595101 aaagaagaca tacttaaggg agaaattccc gaacacatcg ccattatcat ggatggaaat 1595161 ggccgttggg ctaaaaaacg ctctcttccc agaattgcag gccaccatga agggatgaag 1595221 gtggtaaaaa ggaccacgaa gctcgcaaac gaattaggtg tcaaagtact gacattgtat 1595281 gcattttcaa cagaaaactg gaaaagaccg aaaatggagg tcgatttttt aatgaagctt 1595341 ccggaagaat ttttgaatac gtatcttcca gagcttgttg aggaaaatgt acaggttcgg 1595401 atcattgggg atgaaacggc tttgccggcg cacacattac gtgcgattga aaaagctgta 1595461 caggacacgg cgcaaaacga cggaatgatc cttaattttg ctcttaacta tggaggccgt 1595521 actgaaattg tcagtgctgc aaaatcactc gcggaaaaag tgaaggaagg ctctttgaat 1595581 attgaagaca ttgatgaatc gcttttttct acttatttga tgactgaatc tttgcaggat 1595641 cctgaacttt taattcgaac gagcggcgag ataaggctga gtaattttat gctatggcag 1595701 gttgcctaca gtgaatttgt ctttactgac gtcttgtggc ctgactttaa agaagatcac 1595761 ttcttgcagg cgttaggaga gtttcagcag agaggccgga ggtttggcgg aatttagagg 1595821 atggtggaca tgaaacaaag aattttgaca ggtgttctgg cagcaattgt atttttattt 1595881 ttggttattg tcgggaaatt gccgttcacc atattaattt atgctatggg cagtgtggcg 1595941 ctttttgaac ttttacggat gaaaaagctg aagctggttt cactgccggg tttgatcggt 1596001 cttttattat tgtggatgtt cttattacca agccagtatt cgttttttga agcggacggg 1596061 atttccaaaa tggaaatcgc tttatttgcg gtactgctat tgctgactta cacagtgttg 1596121 gtcaagaaca cctttacttt tgatgaagtc gggtttatta cgcttgcagc aatttacatc 1596181 ggaatgtgtt ttcattattt tatcgaaatc agaaatcttg accaatacgg attaacatac 1596241 attttttatg cgtgtgttgt catttggtcc accgattccg gtgcctattt tgtcggtaaa 1596301 tcgcttggga agcggaaact gtggcctgaa atcagtccga ataaaacagt ggaagggttt 1596361 gcaggcggaa ttgtcatcgc acttgtattg gcgacgattt ttcagcttgt tgcacaactt 1596421 ccgatcccgt atatctatct gctgttgatc acgctgtttt tgtctgtttt tggacaactg 1596481 ggagatttag tggaatccgc cttgaaaaga cattacgatg taaaggattc tgggaatatt 1596541 cttcccgggc atggcggtat attagaccgt tttgacagtt tcttgtttgt catgcctttc 1596601 ttgtactttc tgcttgccct tttttcataa aaaagtctaa tatgaatatg agactgatca 1596661 tgcagcaata agaataggag tagtggcaac tttgaaaaat atttgtcttt taggagcaac 1596721 aggatcaatc ggcgaacaga ctcttgatgt actgcgtgca catcaagacc aatttcagct 1596781 ggtatctatg tcgtttggca gaaatattga taaggccgtt ccaatgattg aggtctttca 1596841 gccgaagttt gtctctgtcg gtgatctgga tacatatcat aaattaaaac aaatgtcttt 1596901 ttcttttgaa tgccaaatcg ggctgggaga agaaggactg atagaagcag cagtgatgga 1596961 ggaggttgac attgttgtca acgctttgct tggaagcgtc ggtcttatcc cgacattaaa 1597021 ggcaattgaa cagaaaaaaa caattgcgct tgcaaataag gaaactcttg tcactgcagg 1597081 gcatatagta aaagaacatg ctaagaaata tgatgttccg ctgctgcctg ttgacagtga 1597141 gcattcagcc atttttcaag ctcttcaagg cgaacaggct aaaaacattg aacgcctcat 1597201 cattacggca tccggcggaa gttttcggga caagacgcgg gaggagctcg aatcagtaac 1597261 ggttgaagat gcattaaaac atccaaactg gtcaatgggt gcaaaaatta caattgattc 1597321 ggctacaatg atgaataagg gattagaggt gatcgaggca cactggcttt tcgatatacc 1597381 ttatgaacaa attgatgtgg ttttacataa ggagagcatc atccattcaa tggttgagtt 1597441 ccatgataaa agtgtgatcg cacagctcgg aactccggat atgagagtcc ccattcaata 1597501 tgcgctcact tatcctgacc gattgccatt accagatgcg aaaaggcttg aattatggga 1597561 aatcggcagc cttcattttg agaaagctga ttttgacagg ttccgatgct tacaatttgc 1597621 ttttgaatca ggtaaaatag gaggaacaat gccgacagtg ctaaatgcgg caaacgaagt 1597681 agctgtcgct gcctttttag ctggcaagat accgtttttg gctattgaag actgtatcga 1597741 aaaggcacta acccgccatc aattactgaa aaaaccgagc ctggcggaca ttcaagaagt 1597801 ggacaaagat acccggggat acgtcaattc aatactcaca taaggtggta tgttcgtgaa 1597861 tacagttata gcgtttatca ttattttcgg aacgctcgtt ttcttccatg aactgggcca 1597921 tttattgcta gcccaaagag cgggaattct ctgccgtgaa tttgcgatcg gcttcggtcc 1597981 aaagattttt tctttcaaaa aaaatgaaac agtttatacg atcaggctgc ttccggtcgg 1598041 cggatttgtt cgtatggccg gcgaagatcc ggaaatgatt gaggtgaaac ccggatacac 1598101 ggtcgggctt ctgtttaata aggaagatca agttgagaaa gtcatcatca atcaaaagga 1598161 aaaatatccg gatgctttag tcattgaagt ggaaacagcg gatctagagc atgacatgaa 1598221 gatcaccggt tatgaacagg ggaaagagga cgaactttcc agctttactg tcagcgaaac 1598281 atcctttttt attgtagacg gagaagaagt gcagattgcg ccgtataatc gccaatttgg 1598341 ttccaaacct gtatggcagc ggattaaagc aattgctgca gggccgatta tgaactttat 1598401 tttagcttac gtcattttag tgatgcttgg gctgattcaa ggcgtaccgt caaatgaacc 1598461 tatgctcggg cagctgacag acaatggacg ggcggctgaa gcagggctaa aagaagggga 1598521 ttatatccaa agcattaacg gagagaaaat gaggtcttgg actgacattg tctccgctgt 1598581 aaaagaaaac ccggagaaag aaatggacgt tgcagtaaaa agagataaca aaacgcttca 1598641 tatttcggtg actccggaag ctgttaaaga tgagaacaaa aaaacaatcg gacgtttcgg 1598701 ttcctatgcg ccgactgaaa aaggcgtact ctcagcggtt gcttacggcg cgacatcaac 1598761 agttgatgtc accaaagcca ttttaaccaa tctgagcaaa ttagtaacag gccaatttaa 1598821 actcgatatg ctgtcaggtc ctgtcggcat atatgacatg acagaccaag tggcgaaaac 1598881 agggatcgtg aacttatttc agtttgcggc gtttttaagc attaaccttg ggattgtcaa 1598941 cctgcttccg attccggcac ttgacggagg aagactgttg tttctattta ttgaagcgat 1599001 tcggggcaaa ccgattaaca gggaaaaaga agcatttgtt gtgtttatcg gagtagcttt 1599061 cttaatgctt cttatgctgg ttgtcacatg gaacgatatc cagcggctgt ttttgtaaac 1599121 gaaaagtaaa tcaatcagag gtgcgaagaa atgagacaaa gcttgacgct tattcctacg 1599181 ctccgtgaag ttccagctga tgccgaagca aaaagtcatc agcttcttct gagagcagga 1599241 tttatcagac agaatacgag cggggtatac agctatatgc ctcttgcgta taaggtgatt 1599301 caaaacattc agcagattgt tcgagaggaa atggagaaaa ttgatgccgt agaaatgctc 1599361 atgcccgcat tgcagcaggc agagacatgg caggaatcag gcagatggta tacgtatggt 1599421 cccgaactga tgagactaaa agaccgtcat ggccgtgaat ttgctttagg ggcaacgcat 1599481 gaagaggtta tcacttcgct tgttcgcgat gaggttaaat cttataagcg tctccctctg 1599541 actctttatc aaattcagtc taagttcaga gatgaaaaac gtcctcgctt cggtttgtta 1599601 agaggccgcg aatttattat gaaggatgcg tactctttcc atgcatctgc agagagcctg 1599661 gatgaaacgt atcaaaaaat gtacgaggcc tattctaata tttttgcccg ctgcggcatt 1599721 aatgtaagac ctgttatcgc tgattcaggc gcaatgggag gaaaggatac gcacgaattt 1599781 atggcacttt ctgcgatcgg agaggatacg attgcgtatt ctgatgaatc acagtacgcg 1599841 gctaatatcg agatggctga agttcttcac caggaagttc cttcagatga agagcctaaa 1599901 gctctagaga aggttcatac gcctaacgtg aaaacaatcg aagaactgac tgcgttctta 1599961 caggtttcgg ctgaagcgtg cattaagtca gtattgttta aagctgatga ccgttttgtc 1600021 ttagtgcttg taagagggga tcatgaagtt aacgatatta aagtgaaaaa cttgcttcat 1600081 gcagaagttg tagagcttgc tacacatgaa gaggtcattc agcagctcgg aacagagcca 1600141 ggctttgtag gccctgtcgg tattcatcag gatgtggaag tatatgccga tcaagctgtg 1600201 aaagcaatgg ttaatgctgt tgccggggca aatgaaggag atcatcatta taaaaatgtc 1600261 aatgtgaatc gtgacgcgca aattaaagaa tttgctgatc ttcgttttat taaagaaggt 1600321 gatccttcac cagacggcaa gggaacgatc cgttttgctg agggaatcga agtcggacaa 1600381 gtctttaagc tcggaacacg ctattcagaa gcgatgaatg cgacatattt agatgaaaac 1600441 ggacgcgcgc agccaatgct gatgggctgt tacggaatcg gtgtgtcaag aacgctttct 1600501 gctattgctg aacagcatca cgacgaaaaa ggcttaatat ggccaaaaag cgttgcgccg 1600561 tacgatcttc atattcttgc tttgaacatg aaaaacgatg ggcaaagaga gcttgctgaa 1600621 aagctgtatg ccgatttaaa agcggaaggc tatgaagtgc tctatgatga ccgtgctgag 1600681 cgtgccggcg taaaattcgc tgattcagat ttaatcggcc ttccaatccg catcactgtc 1600741 ggaaaacgag ctgacgaagg aatcgtcgaa gtgaaaattc gtcaaactgg tgagtcaact 1600801 gagatttcag tagacgaatt atctgcgttt atcagcaagc agtaatcacc ataacgattt 1600861 atcaaaaaac atgttaaaat agaaataata gaaggtacct cattgcctga ggtaccttca 1600921 cttatgatgt ttttagggag ggatactgtc ttaatggaac agttatcagt aaacagaagg 1600981 cagtttcaaa ttcttctgca gcagattaat atgacagatg ataccttcat gacatacttt 1601041 gaacatggcg agattaaaaa gctgacaatt cacaaagctt ctaagtcttg gcattttcat 1601101 tttcaattta aatctttgct gccttttcaa atatatgaca cattaacaac gaggctgacg 1601161 caatcgtttg cccacatagc aaaagtgaca tcttcaattg aagttcagga tgccgaggtc 1601221 agtgaaagta tcgttcaaga ctactggtca cgctgcattg aagaactgca gggcatttcg 1601281 ccgccgatta tcagtctttt aaaccagcaa aaaccgaagc tgaagggcaa taaactgatt 1601341 gtcaaaacca aaacagatac agaagcggct gcgctaaaga acaaatacag ttccatgatt 1601401 caagcagaat accgtcaatt tggctttccg gatcttcagc ttgatgctga aatatttgta 1601461 tccgagcaag aagttcaaaa gtttcgggag caaaagcttg cggaagacca agagcgggct 1601521 atgcaggcct tgattgaaat ggagaagaaa gataaagaaa gtgatgaaga ccaagcacca 1601581 tctggtcctc ttgttatcgg ttatcaaatt aaagataacg aggaaatccg aacacttgac 1601641 agcatcatgg acgaagaacg gagaattacg gtccaaggtt atgtgtttga tgtggagacg 1601701 cgcgagctga agagcgggcg cacgctgtgt atcttcaaaa ttacagacta tacaaatagt 1601761 attttgatca aaatgtttgc acgtgaaaaa gaagatgcgg cgctgatgaa gtctctgaaa 1601821 aaaggaatgt gggtaaaagc acgcggaagc attcaaaatg atacatttgt cagagacctt 1601881 gtcatgatcg caaatgacgt aaacgaaata aaagcaaaaa cccgtgaaga ttcagcacct 1601941 gaaggagaaa aaagagtgga attgcatctt cattccccaa tgagccaaat ggatgctgtt 1602001 acgggtatcg gaaagcttgt cgaacaggcg aaaaaatggg ggcatgaggc catcgctttg 1602061 accgaccatg ctgtcgttca atccttccct gatgcgtatt ctgcggccaa aaagcatgga 1602121 attaaaatga tttacgggat ggaagcgaat ctcgtggatg atggcgtgcc aattgcttat 1602181 aatgccgcac atcgtctgct cgaagaagaa acatatgttg tttttgacgt tgagacgaca 1602241 ggattgtctg ctgtatacga taccattatt gagctggctg cagtaaaagt aaaaggcgga 1602301 gaaattattg ataaatttga ggcgtttgcg aacccgcatc gtccgctttc cgccacaatc 1602361 atagagctga cagggatcac agatgatatg ctacaagacg ctccggatgt cgtagatgta 1602421 ataagagatt tcagagaatg gattggcgat gatattcttg tcgctcataa tgcaagcttt 1602481 gatatgggat tcttaaatgt agcctataaa aaacttcttg aagtcgaaaa agctaaaaac 1602541 ccagtcattg atacgcttga acttggacgt tttctctatc cggaatttaa gaaccaccgg 1602601 ttgaacacac tttgtaaaaa gtttgatatc gagctcacac agcatcaccg tgcgatctat 1602661 gatactgagg caaccgctta tttgcttctg aaaatgctga aagacgcagc tgaaaaaggt 1602721 attcagtacc atgatgagtt gaatgaaaat atgggtcagt ccaatgctta tcaaagatca 1602781 agaccgtatc atgcaacatt acttgccgtg aacagcacgg gacttaaaaa tttatttaag 1602841 cttgtgtcac tttctcatat tcattatttt tacagagtgc cgcgtattcc gagatctcag 1602901 cttgagaaat acagggaagg gcttctgatc ggttctgctt gtgacagggg agaggttttt 1602961 gagggaatga tgcaaaaatc gcctgaagag gtggaagata tcgcgtcatt ctatgattac 1603021 cttgaggttc agccgcctga agtgtatcgt cacttgctgg agcttgaact ggtccgtgat 1603081 gaaaaagcgc tgaaagaaat tattgcgaat atcacgaagc tgggggaaaa gcttaataaa 1603141 ccggttgttg ctacgggaaa tgttcattac ttgaatgatg aggataaaat ctacagaaag 1603201 attttaatat cctcacaagg cggggcaaat ccgctgaata ggcatgaact gccgaaagtg 1603261 catttcagaa cgacagacga aatgcttgaa gctttttctt tcttaggtga agaaaaagcg 1603321 aaggagatcg tagtcaccaa tacccaaaag gttgcttctt tagttgatga catcaagccg 1603381 attaaagatg atttatatac gccgaaaatc gaaggcgctg atgaagagat cagagaaatg 1603441 agctatcagc gtgcaagaag catttacggg gaagagctgc ctgaaattgt cgaagcgcgg 1603501 attgaaaaag agttaaagag tattattggc cacggatttg ctgttattta cttgatctct 1603561 cacaaacttg taaaacgttc actagatgac gggtatctcg ttggttcccg tggttccgta 1603621 ggatcttcat tagttgcgac acttactgag attactgagg taaacccgct gccgccgcac 1603681 tatgtttgtc ctgagtgcca gcattctgag ttctttaatg acggttctgt cggttctggt 1603741 tttgacctgc ctgacaagac atgccctcat tgcggaacgc ctttgaaaaa agacggccat 1603801 gatattccat ttgaaacgtt cttaggattt aaaggggaca aagtacctga tatcgatttg 1603861 aacttctcag gggaatatca gccgcaagca cacaattaca caaaagtatt gttcggagaa 1603921 gacaatgtat atcgtgcggg aacaataggc acggtggcag aaaaaacagc ctacggttat 1603981 gtaaaaggct atgccggaga caacaatctt catatgcgcg gtgccgaaat agatcggctc 1604041 gtacagggat gcacaggtgt aaaacgtaca actggacagc accctggcgg tattatcgta 1604101 gttccggatt atatggatat ttatgatttt tcaccgatcc agttcccggc agatgccaca 1604161 ggttcagagt ggaaaacgac tcattttgat ttccactcca tccatgacaa cctgttaaaa 1604221 cttgatattc tcggacacga tgacccgact gttattcgga tgcttcaaga cttaagcgga 1604281 atagatccga aaacaattcc gacggatgat cctgaagtga tgaagatctt ccagggaacc 1604341 gaatcactcg gtgtgactga agaacagatt ggctgtaaaa cgggcactct tggaattcct 1604401 gaattcggaa cccgatttgt ccggcagatg cttgaagata caaagccgac cactttttct 1604461 gagctcgttc agatttcagg cttgtctcac ggaactgatg tatggcttgg caatgcacag 1604521 gagctcatcc acaataatat ttgtgagctg agtgaggtta tcggctgccg tgatgacatt 1604581 atggtttatt taatctatca aggccttgag ccgtcccttg cctttaaaat catggaattc 1604641 gtgcgtaaag gaaaaggatt aacgcctgaa tgggaagaag aaatgaaaaa taacaatgtc 1604701 ccagactggt atattgattc ctgtaaaaag attaaataca tgttcccgaa agcccacgcc 1604761 gcggcatatg tcttaatggc agtccgcatt gcttacttta aagtgcatca tgctcttttg 1604821 tattatgcgg cttattttac cgttcgtgca gatgactttg atattgatac aatgatcaag 1604881 ggctctacag caatcagagc ggtaatggag gatataaacg ctaaaggact tgatgcttca 1604941 ccgaaggaaa agaaccttct gactgtttta gaattagcgc ttgagatgtg tgagagaggc 1605001 tattcattcc aaaaagtcga tttatatcgc tccagcgcca cagagtttat tattgacggc 1605061 aacagtctta ttccgccgtt taactctatt ccagggttag ggacgaacgc tgctttgaac 1605121 attgtaaaag ctcgcgaaga aggcgaattc ctctcaaaag aagatttgca aaagagaggg 1605181 aaagtatcaa aaacgatttt agagtactta gatcgccatg gctgtctgga gtcactgcct 1605241 gatcaaaacc aattgtcact gttctaatat ggaaagcaga atttctcaga aattctgctt 1605301 ctatgcatac ataagcgcaa aaagtgccat cgtaatatta gagtttctgt cacttgctta 1605361 ggtatgaagg taagcgtata tccatttgca ataaaaatat ggttatggta tagttttatt 1605421 ggaaatgcta acgattaccg aggcaaagag tggggaaacc cgctcttttg tattgaacag 1605481 gagaattttg tctcgacatg ttcatcgttt actttttagc ccctgctctt ttgaagcagg 1605541 gtttttatgc agagtgacga gacgaatatg agatcgacag cacaaggagg aagaacatga 1605601 gcaaaaaagt gactgacacc gttcaagaaa tggctcagcc aatcgtagac agccttcagc 1605661 tggaactcgt tgacattgaa tttgtcaaag agggccaaag ctggttcctt cgcgtgttta 1605721 ttgattccga tgacggtgtg gatattgagg aatgtgccaa agtaagcgaa gctttaagcg 1605781 aaaagcttga tgaggcagac ccaatcagcc aaaattactt tcttgaagtc tcatctccag 1605841 gagctgagcg tccgctaaag aaaaaagccg atttcgaaaa atcactagga aaaaacgtat 1605901 acattaagac gtatgagcct attgacggcg taaaagtgtt tgaaggtgaa ctggctgaat 1605961 ttgatggaca aacagtgaca gttgagatca cgatcaaaac aagaaagaaa cggatcaata 1606021 ttccgtatga aaagatagct aatgcaagat tagctgttac attctaatga atacaaatgt 1606081 tttaaggggg gagaccgtta aatgagcagt gaattattag atgctctcac gattcttgaa 1606141 aaagaaaaag gcatcagtaa agaaattatc atcgaagcaa tcgaagctgc gttaatttct 1606201 gcttataagc ggaattttaa tcaagcgcaa aatgtacggg tggatctaaa ccgtgaaact 1606261 ggctccatcc gtgtatttgc aagaaaagat gtcgttgacg aagtatacga ccagagatta 1606321 gaaatctcaa ttgaagaggc acagggcatc catccggaat atatggtcgg cgatgtcgtc 1606381 gaaatcgaag ttacacctaa ggatttcggg cgcatagctg ctcaaacagc gaagcaggtc 1606441 gtcacacagc gtgtgcgcga agctgagcgc ggtgtgattt attctgaatt tatcgaccgt 1606501 gaagaagaca tcatgacagg gatcgtccag cgtctggaca ataaatttat ctacgtgtct 1606561 ttaggcaaaa tagaagcctt gctgccggtt aatgagcaaa tgccgaatga aagctacaag 1606621 ccccatgacc gcattaaggt atatatcaca aaagtagaaa aaacaacgaa gggtccgcag 1606681 atttatgtgt caagaacaca tccaggcctg ttaaagcgtt tgtttgaaat tgaagtgcct 1606741 gaaatttatg atggaactgt cgagctaaaa tctgttgcca gagaagccgg cgaccgttcg 1606801 aaaatttctg ttcgcacaga tgatcctgac gttgatcctg tcggttcatg cgtagggcct 1606861 aaaggccagc gtgtgcaagc aatcgtcaat gaattaaaag gtgaaaaaat tgacattgtc 1606921 aactggtcca gtgatcctgt agaatttgtc gcgaatgcgc tcagcccttc caaagtgctt 1606981 gatgtcattg ttaatgaaga agaaaaagcg acaactgtta ttgttcctga ttaccagctg 1607041 tctctggcaa ttggaaaaag aggacaaaac gcacgcttag ctgctaaact gacaggctgg 1607101 aagattgata ttaagagcga aacggacgca agagaacttg gaatctatcc gagagaactt 1607161 gaagaagatg atgagccgct ctttacggag cctgaaactg ctgaatcgga tgaataagag 1607221 gtgactttag gtgaataaac acaaaaagat cccattacgc aaatgtgtag tgactggtga 1607281 aatgaagcct aaaaaggaac tgatccgagt tgtacggtcg aaagaaggcg aaatctcagt 1607341 agacccgacc ggaaaaaaga atgggcgggg tgcttattta acgctggata aagagtgcat 1607401 cttagcagca aaaaagaaaa acactttgca aaatcaattt caatcacaaa tcgatgacca 1607461 gattttcgat gaattgctgg aactggcgga aaaggtgaaa aaataaaatg tctggaatgg 1607521 aatggtttcc cttgctgggt ctggccaatc gagctcgtaa ggtcgtgtca ggcgaagact 1607581 tggtaataaa agaaatcagg aatgcgcgtg caaagcttgt cctgcttaca gaggatgcat 1607641 catctaacac agcaaaaaaa gtaactgaca agtgcaatta ttataaagtc ccttataaaa 1607701 aagtcgagag tcgcgcggtt cttggacgct ctatcggtaa agaagcccgt gtcgttgtcg 1607761 ccgtcactga ccaaggtttt gcgaataagc tgatcagctt gctcgattaa tatttttggg 1607821 ggtgaacgaa tggctaaaat gagagtatac gaatatgcaa aagcgttaaa tgtttcaagt 1607881 aaggaaattt tgaccgcact gaagaacatg gatttagaag tgaataatca catggccatg 1607941 cttgaagaaa aggccattaa aaagctagat gccaaatata aaaaaggcgg cgcagctgct 1608001 aaatctcaaa agccagcaga aacgaacaaa aacaaacagc cacaaggggt taatcagcaa 1608061 tcagctggaa atcaaccaaa taaaattcga gacggaaaga agaatgacgt gcagaataat 1608121 caatttaaca aaaacaagaa gaataacaac aacaaaaaaa ataaacgcaa caacaacaat 1608181 aataaaaacc aacatcagca aaagcctgta aagccgaaaa aagagcttcc tgagaaaatt 1608241 acattctctg gcactttaac agttggcgca cttgctgaag agcttggcaa agagccttca 1608301 gaactcatta aaaagctgat gcttcttggc gtaatggcaa ccattaacca agagcttgat 1608361 aaagacacaa tcgaactcat tgcatcagaa tatggtgttg aaacagaaga ggtcattgtg 1608421 cttgaagaaa cagagctgga aaaatacgaa gagcctgata atgaagagga tcttgaaatt 1608481 cgtcctcctg tcgtgacaat catgggccac gttgaccatg ggaaaacaac gcttcttgac 1608541 agcatccgta aaacaaaggt tgttgaaggg gaagcaggcg gaatcactca gcatatcggc 1608601 gcttatcaaa ttgaagagaa cggcaagaaa atcacgttct tggatacacc gggccacgcc 1608661 gcatttacaa caatgcgcgc acgcggtgca gaagtaactg atattacgat tcttgtcgta 1608721 gctgccgatg acggtgtcat gccgcaaaca gttgaagcga ttaaccatgc aaaagcagca 1608781 gaggttccaa tcatcgttgc tgtgaataaa atagataaag aatccgcaaa ccctgaccgt 1608841 gtaatgcaag aactgacgga atacggactt gtccctgaag cttggggcgg agaaaccatt 1608901 tttgtgccgc tttccgcttt aactggaaaa ggcattgatg agctcgttga aatgattttg 1608961 cttgtcagtg aggtagagga actgaaagcg aatccgaatc gtcaggcaaa aggaacggtt 1609021 attgaagctg aactcgataa aggcagaggg tcagtcgcga cgttgctcgt acagactgga 1609081 acactgcatg tcggtgatcc gatcgtagtc ggcaatacat ttggccgtgt ccgtgcaatg 1609141 gtcaacgaca ttggccgccg tgtgaaaact gccggcccgt caactccggt tgaaattacc 1609201 ggtttgaatg atgtccctca agcgggagac caattccttg tctttaagga tgaaaaaaca 1609261 gctcgttctg tcggtgaagc ccgtgcttcg aaacagcttg aagagcagcg cagcgataaa 1609321 gcgaagctca gtcttgatga tttatttgag caaattaagc aaggtgatgt aaaagacatc 1609381 aacctcatcg taaaagctga cgttcaagga tctgctgaag ctttaacggc tgcacttcaa 1609441 aaaattgaag tagaaggcgt taaagtgaaa atcatccata caggcgttgg tgcgattact 1609501 gaatcagaca ttatcttggc atctgcttcc aatgcaattg ttatcgggtt taatgtgaga 1609561 ccggacggaa atgctaagag tacggctgaa gctgaaaatg tagatattcg acttcaccgt 1609621 atcatttaca aagtaatcga cgagattgaa gctgccatga aaggtatgct tgatcctgaa 1609681 tatgaagaaa aagtaattgg tcaagtagaa gtacgccaaa cattcaaagt atctaaaatc 1609741 ggtacaattg ccggcggata tgttactgaa ggaaccatta cgcgcgacag cggcctccgt 1609801 ttaattcgtg acggcgtcgt catctttgaa ggcgaagtag atgttctgaa acgctttaaa 1609861 gacgatgtga aagaagtttc acaaggctat gaatgtggta ttacaattaa gaaatacaat 1609921 gacattcgtg aaggtgacat ccttgaagcg tttgtcatgc aagaaattga aagaacgtga 1609981 tcggatttgc ggagtgtgaa tgcatcattt atgatgcagg atcgctaaaa gaaaagcgtg 1610041 ccgttctgaa gcggatttta accagggttc aaaacaagtt caatgtttcg atttcggaga 1610101 ttggctatca ggacacctgg caaagaacca gcttcggaat cgccgctgtt tcttcctctc 1610161 gcgttcaaac agaaaaagaa ctgcagcgcg tcctagcgtt tatcgattct tttcctgaaa 1610221 ttgaacggac gatcactagg acagagtggt tttaacttag aggtgattga attgagtatg 1610281 agagcaaacc gtgtcggcga gcaaatgaaa aaagaactcg gtgatattat cagccgcaag 1610341 ctgaaagacc cgagaattgg ttttctgaca gtaacggatg tacgtgtatc aggtgatttg 1610401 caaattgcaa aggtgtatat ctcggttctc ggtgacgaga aaaaacggga agaagcgctg 1610461 aaagggctgg caaaagcgaa aggatttatc cgatccgaaa tcggcagccg catcagactt 1610521 cgaaaaacgc ctgaaattga atttgagttc gatgaatcaa tcgattacgg gaatcggatc 1610581 gaaacactga ttcacgaatt acattcagag aaaccatctg aataaaaaaa gagaggatag 1610641 gcgtatatcg tctgtcctct ttcttcgttt ataagaaaaa aactcaaaag aaggagtgaa 1610701 aggcaaatgg ttaacggagt tctcctttta cataaacctg ttggcatgac atcgcacgac 1610761 tgtgtcatga agatccgaaa gctgttaaaa acaaaaaaag taggacatac aggaacgctc 1610821 gatccggaag tatcaggcgt gcttccgatt tgtgtaggaa gagcgacaaa aatagtcgaa 1610881 tacttaactg aaaaatctaa aacgtatgat gcagaaataa cattgggctt ttcaaccaca 1610941 acagaggatc aaaccggaga aacggtggaa acaaagcctg tcaatcacga cattgataaa 1611001 gcggatgtag aaaaggtttt aaacagttta aaggggaaac aagaacaaat tccgcccatg 1611061 tattccgctg taaaagtaaa cggcaaaaaa ttatacgaat acgcaagagc agggattgaa 1611121 gtagaacgtc cgaaacgtat gataaccatt gaagacattg ccctgacaac agagattaaa 1611181 catcatggag aaaccgcaag cttccggttt acagtgactt gctccaaagg gacctatgta 1611241 aggacgctgg cggtcatgat cggagaaaag ctcggatatc cggcccatat gtctcattta 1611301 atccgtacgg catccggaga tttttctctc gacgaatgct ttacttttga tgaactcgaa 1611361 gcacaggccc aatccggaac cgtggaagag catacagttc ctattgaacg tgcgctcaat 1611421 catttgccga aatggatcat aagtgataca ttagctaaga aagtagaaaa tggggctttg 1611481 cttgagacgc ccgagcagtt ttctgaaatg acaagtggag accgtattgc cgtctttact 1611541 gaatccggaa cctgcttggc gatctatttc cctcatcctg caaaaaaagg gctgttaaag 1611601 ccggcaaaag tattgatgca aaaaagcgaa caatagaaaa aaggtgaccg ttctgtgaag 1611661 acgatacata ttacacatcc tcatcattta ataaaagagg agcaggcaaa atcagtgatg 1611721 gcgttaggtt attttgacgg cgttcatctc gggcatcaaa aggtaatcgg cacagcgaag 1611781 caaatagccg aagaaaaagg tctgacatta gctgtgatga cctttcatcc ccatccttct 1611841 cacgtgttgg gcagagataa ggaaccaaag gatctgatta cgcctcttga agacaaaata 1611901 aaccaaattg aacaattagg cacagaagtt ctgtatgtcg ttaaatttaa tgaagtgttt 1611961 gcttctcttt ctcctaagca gtttatagac cagtatatta tcggccttaa tgtgcagcac 1612021 gcagtggcag gctttgactt tacgtacggc aaatacggca agggaacaat gaagaccatg 1612081 ccggatgatt tagacggaaa agctgggtgc acaatggtag aaaaattaac ggagcaggat 1612141 aaaaaaatca gttcttcgta tatccgtacc gcgcttcaaa acggagatgt tgaattggcg 1612201 aatgtcttgc ttggacaacc ttattttatt aaaggaattg tcattcatgg tgataaaaga 1612261 gggcggacca tcgggtttcc gacagcgaat gtcggtttaa ataacagcta tatcgttccg 1612321 cccacaggtg tatatgccgt aaaagcggaa gtgaacggcg aagtttacaa tggcgtttgc 1612381 aatattggct ataagccaac gttttatgaa aagcgccctg aacagccttc catcgaggtc 1612441 aatctgtttg atttcaatca agaggtatat ggagccgcta taaaaatcga atggtacaaa 1612501 cggattcgga gcgagcggaa attcaatggc atcaaagaat taactgagca aattgagaaa 1612561 gataagcagg aagccatccg ttatttcagc aatttgcgga aataacttgc aacgcacgca 1612621 aattttattc taaaatattt gcatataggc acgattttta gtatgatagt tttcgtagtc 1612681 ttaaaaccat tgcttggcaa tccgaagtca ccgacggttg ctaggtaact ggggctaaat 1612741 atgatttgga ggtgaaacag gatggcaatt actcaagagc gtaaaaacca actcatcaat 1612801 gagttcaaaa cacacgaatc tgatactgga tctccagaag ttcagatcgc tatcctaact 1612861 gactcaatta acaacttgaa cgagcattta cgtactcaca agaaagacca ccactcacgt 1612921 cgcggtcttc ttaaaatggt aggtaagcgt cgtaatcttc ttacgtatct gcgtaataaa 1612981 gacgtaactc gttaccgtga gttaattaac aaactaggct tacgtcgata atcgtaaaaa 1613041 gcgggaggat tcccgctttt ttatcgtatt aaagcgaaat ttcttataac aaatcattga 1613101 aatcctttta catactactt tgacattgat atgttcaatt catttcgttc ataataggag 1613161 taattgatta tttcacacaa cgaagagagg agttcgtaat tgtatgggac aagaaaaaca 1613221 tgtctttacc atagattggg ccggaagaac gcttaccgtt gaaaccggcc agcttgccaa 1613281 acaggcaaat ggtgctgtga tgatccgcta cggtgataca gcagtactta gtacagcaac 1613341 cgcttcaaaa gaacctaaac cgcttgattt cttccctctt actgtaaact atgaagaaag 1613401 attatatgcg gtagggaaaa ttccgggcgg atttattaaa agagaaggac gtccaagtga 1613461 aaaagcggtt cttgccagcc gtttaattga ccgtccgatc cgtcctttgt ttgccgatgg 1613521 attccgtaat gaagttcaag tcatcagcat tgtcatgagt gttgaccaaa actgctcttc 1613581 agaaatggct gccatgttcg gttcatctct tgcactttct gtatcggata ttccgtttga 1613641 aggaccgatt gcaggggtta ctgtcggacg cattgatgat caatttatca ttaacccgac 1613701 agtcgatcag cttgaaaaaa gcgatatcaa tcttgtcgtt gccggcacga aagatgcgat 1613761 taacatggta gaagcgggag cggacgaagt tcctgaggaa atcatgcttg aggccattat 1613821 gttcggccat gaagagatta aacgcctgat tgcattccaa gaagaaattg ttgcagcagt 1613881 cggcaaagag aaatctgaaa ttaagctctt tgaaattgat gaagagctta atgaaaaagt 1613941 aaaagctttg gcagaagagg atctgctgaa agccatccaa gttcatgaaa agcatgcccg 1614001 tgaagatgcc attaacgaag tgaagaacgc agttgtggca aaattcgagg atgaagaaca 1614061 tgatgaagac acaatcaagc aagtgaagca gattttatcc aagcttgtga aaaatgaagt 1614121 tcgccgcctg attactgaag agaaagtaag accggacggc cgcggtgtcg atcaaatccg 1614181 tccgctctct tcagaggttg gcctcttgcc aagaacgcac ggttcaggtc tatttacaag 1614241 gggacaaact caggccctca gcgtatgtac gctaggtgct ctgggagatg tgcaaatcct 1614301 tgacggctta ggtgtcgaag agtcgaaacg gtttatgcat cattacaact tcccgcaatt 1614361 cagcgttggg gaaacaggac cgatgcgcgg accgggacgt cgtgaaatcg gacacggagc 1614421 actgggtgag cgtgcgcttg agccagttat tccgtctgaa aaagacttcc cttatactgt 1614481 ccgtcttgtt tcagaagtgc ttgaatcaaa cggttctaca tctcaagcaa gcatttgcgc 1614541 aagcacactt gcaatgatgg atgccggtgt accgattaaa gcgccagttg ctggtattgc 1614601 gatgggtctt gtcaaatcag gcgaacatta cactgtcttg actgacatcc aaggcatgga 1614661 agacgcgctc ggagatatgg actttaaagt agcgggaact gaaaaaggcg taacggccct 1614721 gcaaatggac attaaaattg aaggcctttc cagagagatt cttgaagaag cgcttcagca 1614781 ggcgaaaaag ggcagaatgg aaatcctcaa cagcatgctt gcaacattaa gcgaatcaag 1614841 aaaagagctt tctcgatatg cgcctaagat cttaacaatg accattaatc ctgataaaat 1614901 ccgcgatgtc atcggaccaa gcgggaaaca aatcaataag atcatcgaag aaaccggtgt 1614961 taaaattgat attgagcagg acggcacaat ctttatttcc tctacagatg aaagcggcaa 1615021 ccaaaaagcg aaaaaaatca tcgaagacct tgtgagagag gttgaagtcg gccaacttta 1615081 cctaggtaaa gtgaaacgga ttgaaaaatt cggggctttc gttgaaattt tcagcggaaa 1615141 agacggtttg gtgcacattt cagagcttgc gcttgaacgc gtagggaaag ttgaagatgt 1615201 tgtgaaaatc ggagacgaga ttcttgtcaa agtcactgaa attgataaac aaggacgagt 1615261 gaatttatcc cgcaaagcgg tgctccgtga agagaaagaa aaagaagaac aacaatctta 1615321 aatgaaaaca taaaaggagc ctgggagacc cggcttcttt attttgaagc ttttcaaaag 1615381 caggcgggtt ctaccttgtc cttctccttc ataatgtgag gtgagggggg gacagaacat 1615441 gtacaaaaaa tttgtaccgt ttgccgtttt tttatttctt ttttttgtct catttgagat 1615501 gatggaaaat ccgcatgcac ttgattatat aggggcaatg aaaaaagata cggtgactgt 1615561 cacggcgtca aaagacccgt tatatgaaga attgcttcaa aaagcgccgg agtacgaagt 1615621 taagccccag aatgcaagaa ttgataaagt gtggaaaagc attccaggct acaatggatt 1615681 aaaggtcaat attgaacaat catataaaaa aatgaaacag catggtaagt ttcgggaaaa 1615741 agatttggtg tacagtcaag taaaaccaag tgttcatctt gagtcacttc agcctgagcc 1615801 tatttataaa ggaaatcctg acaaaccgat ggtggctttt ttaatcaatg tggcatgggg 1615861 aaatgagtat ttggaaaaaa tgcttcctat tctgcaaaag caccaggtta aagctacgtt 1615921 ctttttagaa ggcaattggg tgagaaacaa tgtacagctc gctaagaaga ttgcaaaaga 1615981 cggacatgaa atcggaaatc attcatacaa tcatccggat atgagcaaac tgactacagg 1616041 aagaatttcc gagcagctcg acaagactaa tgaacaaata gaacaaacga tcggcgttaa 1616101 gccaaagtgg ttcgctccgc caagcggaag tttcagaaaa gcggttatcg acattgcagc 1616161 agagaaacag atgggaacag tcatgtggac agttgataca atcgattggc aaaagccggc 1616221 tccgtctgta cttcagacga gagtgttaag caagatacat aatggtgcca tgattttaat 1616281 gcatccgact gaccctacgg cggaaagtct tgaagcgctg attacacaga taaaagacaa 1616341 aggatatgcg cttggaacag tcactgaact aatggatgaa acaagactat tgaagtaaca 1616401 gatgaaggca gcttgtcttt gaataggagg aacaaatttg attaaacgat atacgtgtca 1616461 aaatggtgta agaattgtgc tggaaaataa cccgacagtc cgttctgttg cgatcggcgt 1616521 atggatcggc acaggttcga gacatgaaac gccggagata aacggaattt ctcacttttt 1616581 agagcacatg ttctttaaag ggacgagcac aaaatctgca cgcgagatag cagaatcttt 1616641 tgatcgtatt ggcggccagg tcaatgcgtt tacttcaaag gaatatacct gctactatgc 1616701 aaaggtgctt gacgagcatg cgaattacgc gctggacgta ttagcagata tgttctttca 1616761 ttcaacgttt gatgaaaacg agctgaaaaa agagaaaaat gtagtatatg aagaaattaa 1616821 aatgtatgaa gatgcgccgg acgacattgt acatgattta ttgagcaaag ccacttacgg 1616881 caatcattct ttaggctacc caattttagg aacggaagaa acgcttgctt cctttaacgg 1616941 tgactctctc agacaataca tgcatgatta ttatacgccg gaccgagtgg tgatttcggt 1617001 agcgggcaat atatctgaca gttttatcaa agatgtagaa aaatggttcg ggtcatacga 1617061 ggcgaaaggc aaagcgacag gccttgagaa gcctgagttc cacacggaaa aactgacgag 1617121 aaaaaaagaa acagagcagg ctcatttgtg ccttggattt aaaggcttag aggttggcca 1617181 tgaacgtatt tatgatttaa tcgtcctcaa caatgtgctc ggaggcagca tgagcagccg 1617241 gctgttccaa gatgtgcgtg aagataaagg acttgcttat tctgtttaca gctatcacag 1617301 ctcatatgag gacagcggaa tgctaacgat ttacggcgga acgggtgcaa atcagcttca 1617361 gcagctgtcg gaaacaattc aagaaaccct ggccacatta aaacgtgacg gcattacctc 1617421 gaaagaactg gaaaacagca aagagcaaat gaagggaagc ttaatgctga gcttagaaag 1617481 cacaaacagc aaaatgagcc gaaacggaaa aaatgaactg ctgctcggca aacataaaac 1617541 attagatgaa attatcaatg aattaaacgc cgtgaactta gagcgtgtta atggccttgc 1617601 cagacaattg tttaccgaag actatgcatt agcacttatc agcccttccg gcaatatgcc 1617661 gtcttaaaaa ggaaagcctg ccccataatg gagcaggcat tttttaatcc ctttcatcat 1617721 acatagtaca agggggtgac agacatgcgg ctcagtgaat tatcgggaaa ggaaattgta 1617781 gacatcaaaa gagctgaacg gctcggagtg ctcggccaga ccgatttgga aatcaatgaa 1617841 caggatggac agattacagc actcctcatt cccacagtta agtggtttgg tttgagaaag 1617901 caaggtcatg acattcgtgt cccatggcac catattcaaa agatcggttc agatatgatt 1617961 atattagatg tacctgagga aatgcctcct cgacaagagt aaatagccca attgactgtg 1618021 aagcgggctc taaagaaaac atctgaaaca tcggctgccg gagccgatgt ttttttatat 1618081 ggaaaaagcg catcttttat attcaccggt atttcctttt gatcataaga tgaaggggag 1618141 cttaacaact agagatccag tatatacaaa gaaggtgaac gtttagaatg ttaaccggat 1618201 tgaaaattgc agttatcggc ggtgacgcaa gacagctcga aattataaga aagctcactg 1618261 aacagcaggc tgacatctat cttgtcggtt ttgaccaatt ggatcacggt tttaccgggg 1618321 cagtaaaatg caatattgat gaaattcctt ttcagcaaat agacagcatc attcttccag 1618381 tatccgcgac aacaggagaa ggtgtcgtat cgactgtatt ttcgaatgaa gaagttgtgt 1618441 taaaacagga ccatcttgac agaacgcctg cacattgtgt cattttctca ggaatttcta 1618501 acgcctattt agaaaacatt gcagctcagg caaaaagaaa acttgttaag ctgtttgagc 1618561 gggatgacat tgcgatatac aactctattc cgacagtaga aggaacgatc atgctggcta 1618621 ttcagcacac ggattatacg atacacggat cacaggtggc cgttctcggt ctggggcgca 1618681 ccgggatgac gattgcccgt acatttgccg cgctcggggc gaatgtaaaa gtgggggcaa 1618741 gaagttcagc gcatctggca cgtatcactg aaatggggct cgttcctttt cataccgatg 1618801 agctgaaaga gcatgtaaaa gatatagata tttgcattaa taccataccg agtatgattt 1618861 taaatcaaac ggtactttct agcatgacac caaaaacctt aatattggat ctggcctcac 1618921 gtcccggggg aacggatttt aaatatgccg agaaacaagg gattaaagca cttcttgctc 1618981 ccgggcttcc agggattgtc gctcctaaaa cagctgggca aatccttgca aacgtcttga 1619041 gcaagctttt ggctgaaata caagctgagg aggggaaata aggatgtcgt cattaaaagg 1619101 aaaaagaatc gggtttgggc tgaccgggtc gcattgcaca tatgaagcgg ttttcccgca 1619161 aattgaggag ttggtcaacg aaggagctga agtccgtccg gttgtcacat ttaatgtaaa 1619221 atctacaaat acccgatttg gagagggcgc agaatgggtt aaaaaaattg aagacctgac 1619281 tggatatgag gccattgatt cgattgtaaa ggcagaacct cttgggccga agctgcccct 1619341 tgactgcatg gtcattgcgc ctttaacagg caattcaatg agcaagctgg caaatgccat 1619401 gacggacagc ccggtgctga tggcggcaaa agcgacaatc cggaacaatc ggcctgtcgt 1619461 tctgggtatc tcgacaaatg atgctcttgg tttaaacgga acaaatttaa tgaggctcat 1619521 gtcaacaaaa aatatctttt ttattccatt cgggcaagat gatccattta aaaaaccgaa 1619581 ttcaatggta gccaaaatgg atctgcttcc gcaaacgatt gaaaaggcac tcatgcacca 1619641 gcagcttcag ccgattctag ttgagaatta tcagggaaat gactaaattt acagaaaatc 1619701 tttcccaaac taaaaaattc ggtcatcacc cgcatattct atggtaaaat aaaacgtaaa 1619761 atcatagtca aatcaattca atgaagctga ttggcggaag gagttttaca gatgggaaga 1619821 ggtttacacg tagctgttgt cggagcgaca ggggctgtgg gacaacaaat gcttaaaaca 1619881 cttgaagaca gaaactttga aatggacaca cttacattgc tatcttcaaa acgctctgcg 1619941 gggacaaaag tcacgtttaa aggccaagag ctgactgttc aggaagcttc tcctgagagc 1620001 tttgaagggg taaatattgc tttgttcagc gccggcggaa gcgtatcaca agcattggca 1620061 ccagaagctg taaaacgcgg cgctattgtt atagataata cgagtgcgtt ccgcatggat 1620121 gaaaatacac cgcttgttgt gccagaagtg aatgaggcag acttgcatga acacaacggc 1620181 attattgcca atccaaactg ctctacaatc caaatggttg cggcacttga accgatccgc 1620241 aaagcatatg gcttaaacaa ggtcatcgta tcaacttacc aggcagtatc aggagcgggt 1620301 aatgaagctg taaaagagct ttacagccaa acacaggcga ttttaaataa agaagaaata 1620361 gagcctgaga tcatgcctgt aaaaggtgac aaaaaacact atcaaatcgc cttcaacgcg 1620421 attccgcaaa tcgataaatt ccaagataac ggctatacgt ttgaggaaat gaaaatgata 1620481 aatgaaacga aaaaaatcat gcacatgcct gaccttcaag tagcggctac atgtgtgaga 1620541 ctgccaatcc aaactgggca ctcagagtcc gtctacatcg aaatagaccg tgatgacgct 1620601 acagttgaag atattaaaaa tctattgaaa gaagctccgg gcgtgacact tcaggatgat 1620661 ccaagccagc agctttatcc gatgcctgct gatgctgtcg gcaaaaacga tgtgtttgta 1620721 ggccgcatcc gcaaagactt ggacagagca aacggttttc atttatgggt tgtttctgat 1620781 aacctattaa aaggcgcggc atggaactct gttcaaattg cagaaagcct gaaaaaacta 1620841 aacctcgtat aaaagagaga attttctaaa gacgaataga agagagtaag gcgctatcag 1620901 cctgctctct tctgttacgt ccgaataatt tggagtgaaa acagtgaaga taattgttca 1620961 aaagttcggc ggaacatcag taaaagatga taaaggccgc aaactggctt tagggcatat 1621021 taaagaagca atcagtgaag gatataaggt tgtcgttgtc gtttcagcga tgggccgaaa 1621081 aggggacccg tatgcaacag attctttgct cgggctgctt tacggcgatc agtcagcgat 1621141 ttctcctagg gagcaggatt tgcttttatc ttgcggagag actatttcct ctgtcgtctt 1621201 tacaagcatg ctgcttgata acggtgtgaa agcagctgcg ctgacagggg ctcaggctgg 1621261 ctttttaacg aatgatcagc atactaatgc gaaaatcatt gaaatgaaac cggagcgttt 1621321 attcagtgtg ctcgccaatc atgatgcggt agtcgtcgca ggcttccagg gcgcaactga 1621381 aaagggtgat acaacaacaa tcggcagagg gggcagcgat acgtctgcag ccgcactcgg 1621441 agcagctgtt gatgcggaat acatcgatat tttcaccgat gtagaaggcg tgatgactgc 1621501 tgacccaaga gtggtagaaa atgcaaaacc gcttcctgtt gtgacgtata cggaaatctg 1621561 caacctggcg tatcaggggg ccaaggtcat ttctccgcgt gctgtggaaa tcgcaatgca 1621621 ggccaaggtt ccgatccgcg tccgttcgac ttattcgaat gataaaggca cattggtgac 1621681 atcacatcac tcttccaagg tcggcagtga tgtttttgaa aggctgatta cgggaatcgc 1621741 ccatgtcaaa gatgtcacgc agttcaaagt gcctgcgaaa atcggccagt ataacgttca 1621801 gactgaagtg ttcaaggcta tggcaaacgc tggaatcagt gtcgatttct ttaacattac 1621861 acctagtgaa atcgtctata cggtagccgg aaataaaaca gaaacagctc agcgtatttt 1621921 aatggatatg ggctatgatc caatggtgac gagaaactgc gcgaaggtat cggcggtcgg 1621981 cgcgggcatt atgggtgttc ccggtgttac gtccaaaatt gtatcggctc tttcagaaaa 1622041 agaaattccg atccttcagt cggctgacag ccatacgacg atatgggtgc tcgtccatga 1622101 agcggatatg gttcctgctg taaacgcttt gcatgaagtg tttgaacttt cgaagtaaat 1622161 gtgattgaat catgatgagg tgaataaaat gaatttcgga aatgtgtcta cagcgatgat 1622221 tacacccttt gacaataaag ggaacgtaga ctttcaaaaa ctgtctacac tgattgatta 1622281 cttgttgaaa aacggaacgg attctttagt agtagcggga acaactggag aatctccgac 1622341 cctttcaact gaagaaaaaa ttgcgctttt tgaatatacg gtaaaagaag taaacggacg 1622401 ggtgcccgtt atcgctggta ctgggagcaa caacacgaaa gattccatta agctgacaaa 1622461 aaaagctgag gaagcgggcg tggacgctgt tatgcttgtt accccgtatt acaataaacc 1622521 ttctcaagaa ggaatgtacc agcattttaa agcaattgcg gcagagacat ctcttccggt 1622581 tatgctctat aatgttcctg gccgtacggt tgcttctctt gctcctgaaa cgacgatccg 1622641 tttggcggca gacattccga atgtggttgc gattaaagaa gcgagcggag acctcgaagc 1622701 gattacaaaa attattgctg aaacacctga agacttctat gtctattcag gggatgatgc 1622761 tctaacgctt ccaattcttt cagttggagg tagaggagtt gtgtcagtgg cgagccatat 1622821 tgcaggcact gatatgcagc aaatgatcaa aaattatacg aatgggcaaa cagctaatgc 1622881 ggcactgatt catcagaaac tgctgccgat tatgaaggaa ctgtttaaag cgcctaatcc 1622941 tgctccagtc aaaacagcgc ttcagctgag aggtcttgat gtcggttctg tgcgtctgcc 1623001 tctagtccca ttaactgagg atgaacgtct gagcttaagc agcacgatca gcgaactgta 1623061 agaaaatttc atacagtgaa acaaacgcgg tcattctcac attcagctga gtttgaccgt 1623121 ttcttttaca tattggtttt ccctaaacct tctgctttat cttgttttct aaatttactt 1623181 tcagttataa taggaacaag tgatgatgga cgggtatgag actaggagga tatagatttt 1623241 gaaaaagaaa aatacagaaa acgttagaat tatcgccctt ggcggtgtcg gagagattgg 1623301 gaagaacctt tatgtcattg aaattgactc agacatattt gtcgttgatg ccggccttat 1623361 gcatccagaa aacgaaatgc tcggtattga tgtagtgatt cctgacatat catatttgat 1623421 tgaacgggct gaccgcgtca aggcaatctt tttaacgcac gggcacgatg aaaatatcgg 1623481 cggcgttttt tacttattaa acaagctgtc cgttccagtg tacggaacaa aactgacgct 1623541 tgcactgtta agagagaaat taaaacaata cggacataac cgaaaaactg atttaagaga 1623601 aattcactcc aaatctgtca ttacatttga atcaacaaag gtatcgttct ttagaacgat 1623661 tcacagcatt cctgattctg taggtgtgag ctttaaaaca tcacttggat ctattgtatg 1623721 cacgggagac ttcaaatttg accaaacacc tgcacttaat cagacgtgcg acattggcga 1623781 gatcgccaag atcggcaata gcggcgtgct cgctctgctt tctgacagtg caaatgcgga 1623841 acggccgggt tacacccctt cggaagcggc tgtcagcgga gaaatttcgg atgcgctgta 1623901 taattcacag aaccgggtga ttattgctgt tttcgcatcc aatattaacc ggattcagca 1623961 agtcattcat gcagcggctc aaaatggcag aaagattgcc gtagccggaa aaaatcttca 1624021 atctgtcctg cagctggcga gaaagttagg atatattgaa gcagatgatg aattgtttat 1624081 ttctgtacag gatgtcaaaa aatatccgaa gcgcgaagtg gccattatta cagccggaag 1624141 ccaaggtgaa ccattagctg ctttgacaag aatggcaaac aaagctcaca aacagctgaa 1624201 cattgaagaa ggggatacgg tggtcattgc gtcaactccg attcccgggc aggaactcat 1624261 ttactctaaa acagtagatc ttcttgcgag agccggtgca caagtcatct ttgcccaaaa 1624321 gcgtgttcat gtatcaggcc acggctcaca agaagagtta aagctgatga tcaacctgct 1624381 taaaccaaaa tatttgattc ctgtaaacgg cgaatacaga atgcaaaaag ctcattcaaa 1624441 aatcgctgaa gaaaccggca tgaagcgcag tgacatcttc ttaattgaaa aaggcgacgt 1624501 cgttgaattc cgcggccaaa acgtaaaaat tggggataaa gttccttacg gcaatatttt 1624561 aattgatggt ttaggtgtcg gtgatatcgg caatatcgta ttgagagacc gccgcttgct 1624621 ttcacaggac ggaattttaa tcgttgtcat tacacttgat aaacaaaaga aacatcttgt 1624681 atcaggacca gaaattatca ctcgcggctt tgtttatgta agagagtctg aaggtcttat 1624741 cgtacaggct actgagcttg tacggtccat cgtgacagaa gcgactgaaa catcaaatgt 1624801 cgaatggtca acgctgaagc aggcaatgcg ggatgctttg aaccaattcc tttatgaaaa 1624861 aacgaaacgt aaaccgatga tcatcccaat tattatggaa gtataatgac tgactaaaga 1624921 ccggagctgc tccggtcttt attttttgtc cttcaagccg ggattgaatg aagtatcttt 1624981 gttcataata caaagagaaa ctcggaaagg atgaaagcga gatggatcat cgtatggaaa 1625041 acacagaaga agagcgtcct gaaaaaaatg atgcgaagga cagcattatg aataaaatac 1625101 agcagcttgg tgaaacgacg cttccgcagc tgccccaaga tacaaatatt cattgtctga 1625161 ccattatcgg acaaattgaa ggccatgttc agcttcctcc gcaaaacaaa acaacaaaat 1625221 atgaacatgt catcccgcag attgtggcaa ttgaacaaaa tcccaaaatt gaaggcttgc 1625281 tgatcatatt aaatactgtc ggaggagatg ttgaagctgg tcttgccata gcggaaatgc 1625341 ttgcatcttt atcgaaaccg accgtttcta tcgtgcttgg cggggggcat tcaatcggcg 1625401 ttccgattgc tgtatcctgt gattacagct atatcgccga aacagcaacg atgacgattc 1625461 atccagttag gctcaccggg ctggtcatcg gggtgccgca aacgtttgaa tacctggata 1625521 agatgcaaga aagagttgtt aaatttgtga caagccattc caatataacc gaagagaagt 1625581 ttaaagagct aatgttttca aaaggaaact taacacgcga tatcggaaca aatgtagtcg 1625641 gtaaggatgc agttaaatac ggattgatcg atcacgcagg cggtgtcgga caggcaatca 1625701 ataaactgaa tgagctcatc gatgaagcaa ggaaagaaga aggacggatg attcaatgat 1625761 tctttatacc gtgatgcctc aggaaattgt gtttgcagaa cagaaccaag agacaagcgc 1625821 acatgagcaa attgaatata aaggtgtacc gcttctagtc gaaatgaaag ggaatgaagc 1625881 ggaagtcatt caaatcatga gcaccaatcc aatgcatttt ctgcatccgg acatttcacc 1625941 gggacaaaag ctgaaattaa acgtataaga atccaaccct tttttaaggg caaaatatgc 1626001 tataataggg gaatcctaca gaaaaaacgc agcctgtaaa cggctgcttt cttcattatg 1626061 tatgaactta cattttttaa cgcagtaagg tgatgagtgt ggcaaagaaa aaacgaaaat 1626121 caagaaaaaa acaggcgaaa cagctcaata taaaatacga gctcaacgga ttgctgtgta 1626181 tagccatttc aattatcgca atcttgcagc tgggggtagt cgggcaaacg tttatctatt 1626241 tgttccgctt ttttgctgga gagtggttta ttttatgctt gttaggttta ttggtgttag 1626301 gagtctcact gttttggaag aaaaaaaccc caagcctttt aacgagacga aaggccgggt 1626361 tgtactgtat tatcgcaagc atattgctgc tttctcacgt gcagctattt aaaaatttga 1626421 cgcacaaagg gtctattgag tctgcaagcg tggtgcgcaa tacgtgggaa ttgtttttaa 1626481 tggacatgaa tggcagctct gcttcacctg atttaggcgg agggatgatc ggtgcgctgc 1626541 tgtttgcggc ttcacacttt ttgtttgcgt cgactggttc tcagatcatg gcaattgtca 1626601 tgattttgat cggaatgatt ttagtaacag gacgctcgct gcaagaaacg ctaaaaaagt 1626661 ggatgagccc gattggacgt tttataaaag aacaatggtt agcatttatt gatgacatga 1626721 aatccttcaa atcaaatatg cagtcatcga aaaaaacgaa agcgccgagc aaaaaacaaa 1626781 aaccggcccg caaaaaacag caaatggaac cggagcctcc tgatgaagag ggggattatg 1626841 aaacagtatc gcctcttatt cattcagagc cgattatctc aagcttttct gatcgtaatg 1626901 aagaggaaga gtctccagtt atagaaaagc gcgccgaacc tgtgtcgaag ccgcttcagg 1626961 acatccaacc ggagacaggt gatcaggaaa ctgtttctgc tcctcctatg acctttacag 1627021 agctcgaaaa taaggattac gagatgccgt cactggattt gctggcagat ccgaagcata 1627081 ccggccagca ggctgataaa aagaatattt atgaaaatgc gagaaagctt gaacgcacat 1627141 tccaaagctt tggcgtaaag gcgaaagtca cacaggttca tctcggaccg gccgtaacaa 1627201 aatatgaagt atatcctgat gtcggagtga aggttagcaa aattgtcaat ttaagcgatg 1627261 atttagcgct tgcgcttgct gcgaaggata tcaggatcga agcgcctata ccaggcaaat 1627321 cagcaatcgg aattgaagtt ccaaacgcag aagtggcaat ggtttcgctg aaagaagtgc 1627381 tggagtctaa attgaatgac agaccggatg cgaagctgtt aattggactc ggccgcaata 1627441 tttcaggtga agctgtattg gctgagttaa acaagatgcc ccaccttttg gtcgcaggcg 1627501 caaccggtag cgggaaaagt gtctgtgtca acggcattat tacaagtatt ttaatgcggg 1627561 cgaaaccgca tgaagtgaaa atgatgatga tcgatcctaa aatggtagag ctaaatgtct 1627621 acaacgggat tccgcatttg cttgctcctg ttgtaaccga tccgaaaaaa gcgtcgcagg 1627681 ctttgaaaaa ggttgtcaat gaaatggagc ggcggtacga attattttct catacgggta 1627741 caagaaatat tgaaggatac aatgattata taaaacgcgc caacaatgaa gaaggagcga 1627801 aacagccaga gctgccttat attgttgtca ttgtggacga gctagccgat ctcatgatgg 1627861 tcgcttcatc tgatgtggaa gattcgatta cgagattgtc ccaaatggcg cgggctgccg 1627921 gcatccatct tattattgcg acacagcggc catcggtgga tgttatcaca ggggtgatca 1627981 aagcgaacat tccgtcacga atcgcgttca gcgtatcttc acagacggat tcaaggacca 1628041 ttcttgacat gggtggcgct gagaagcttc ttggccgcgg cgatatgctg tttttacctg 1628101 taggggctaa caaacctgtc cgtgtgcagg gagcattttt gtcggatgac gaagtggaga 1628161 aggtcgtcga ccatgtgatt actcagcaga aagcgcaata tcaagaagaa atgattcctg 1628221 aggagacgac ggaaactcat tccgaggtta ctgatgaact ttatgatgaa gctgttgaat 1628281 taatcgtcgg catgcagacg gcatctgttt caatgctgca aagaagattc agaattggct 1628341 atacgagagc ggcgcgcctg attgacgcaa tggaggaacg cggtgttgtc ggaccgtatg 1628401 aaggcagcaa acctagggaa gtattattat caaaagagaa atatgatgag ctctcttctt 1628461 aatgaaggga gttccgcttt ctatagttgt caataatgat attatgtaaa ctgatcacct 1628521 ttctatttat tttttcgaca aaacatgata tagttgtccc aattgttcaa taatttttat 1628581 cgaaagtggt ttacggaggg gaaacatgtc tacaaaagct gataatcggc acttgtattt 1628641 gaaagtaatt gaacgaatta aagaggatat aaaaaatggg atctacactg agaaggaaaa 1628701 gctgccttct gaatttgagc tttccaaaaa gcttggtgtc agcagagcga cgctaagaga 1628761 agccttgcgg atactggaag aagagcatgt gattatcaga aggcatggtg taggcacttt 1628821 tgtccattct aagccgttat ttctttcggg tattgaacag ctgaacagtg taaccaagat 1628881 gatagaacag gcgaatatga cccctggcac gatttttcta tcatcacaag tgcttatgcc 1628941 gtctgaagat gatacgaaga gatttcactt ggcagaaggg caagaacttt tttaccttga 1629001 acgagtcagg acagctgacg gacagccgat tgtgtattgt atagacaaaa ttccgatgaa 1629061 tattttgccg aattcttttt ctcatcagca agaatctatg tttgacctgc tagagaaaaa 1629121 ttcaggctcc gtaatcagct atgcagtaac tgatatagaa ccgatcggct atcacgatac 1629181 catttctcca gtgcttgaat gcgatccgga aacagctctt ttgctgttaa aacaaaccca 1629241 ttacgatcag cacgataaac cggtgcttta ttctttaaat tattttagag cggataaatt 1629301 cagatttcat gttttgcgta aacgattcta aaaacggacg cctgtatgtg tctgtttttt 1629361 tatttgcact gattcatgtt tctttgtaca tactttcatt ccggttaacg caatatataa 1629421 gggatgacaa gaaagtgaat gggtgaaaat gttgagagag aaaaatggaa tgaaaaatat 1629481 tattgcattg tcttctgtcc cgcttgtgat gacactcggg aactccatgc tgattcctgt 1629541 tcttccgatg atggagaaaa agctgtctgt gacttcattt caagtatctt taatcattac 1629601 tgtatattca gtagtagcaa ttatttgcat tccgattgcc ggatatttgt cggatcgttt 1629661 cgggagaaaa aaaatattgc ttccatgcct cctcattgca ggattggggg gagccgtagc 1629721 tgcttttgcc tcgacctata tgaaaaatcc ttatgctatg atcttggcgg ggcgggttct 1629781 tcaaggcatt ggttctgcag gtgccgctcc gattgtcatg ccgtttatcg gcgacctgtt 1629841 taaaggagac gatgaaaagg tcagcgcggg tcttggcgat attgaaaccg ccaacacgtc 1629901 agggaaggta ctgagtccca tacttggagc cttactggct tcttggtatt ggtttgtacc 1629961 gttttggttt attccgtttt tctgtttgat cagctttttg ctcgtattgt ttttggtggc 1630021 caagcctgaa gaagatgaag atgcgcctgc tgtttctgag tttattaaga gtgtgaagaa 1630081 aatttttaaa caggatggtc gctggcttta tacggtcttc attatcgggt gtgtcattat 1630141 gtttttgtta tttggcgtat tattttattt atcagatacg ctggagaaca agtatgctat 1630201 tgacggagta gctaaaggcg gattactggc aatcccactt ttgtttttgt caaccagttc 1630261 ttttatagct ggcaaaaaga tcggtaaaga taaaggccga atgaaatttt gcgttgttac 1630321 aggaatgatt ctgttaaccc tttcgtttat tgccttgtgg tggaaccaca gtttttattt 1630381 tttatttgtc tttttaagct ttggcgggat tgggattgga atggctcttc ctgctttaga 1630441 tgcattgata accgaaggga ttgaaagtga acaatgcgga accatttcct ccttttacaa 1630501 tagcatgcgc tttataggag tagctctcgg tccacctgtt tttgctgcat taatgtctaa 1630561 tgcaaactgg attattttca tactctcggc gttttgcagc atcgtttctt tatttttagt 1630621 gctctttact gtagatgcta aaaaaagtga agaagaaaaa aacttaggga cggtctagcc 1630681 agccgtcttt ttttgcgctt tcttgcacag tttacaactg tacctataca gcatgcggag 1630741 gttattgttt ccttataaat cctacagttg ctataattac atgaaagagt gtttctgcgg 1630801 atgctgaaaa ttggtcataa tacatactaa ttaagaaatg aacgaaggag gttccatatg 1630861 tcatatgtta atgaactcaa atcaaagcac ggcggtttaa ccgcacacat tgtaaaaaca 1630921 gaaaaattca aaaccgtctc gcttattttt aagatgcttg cgccgctgac aaaggatcaa 1630981 gtcaccaaaa gagcgcttct cccgcatgtg cttcttcgcg gaacgaaaag ccatccgaaa 1631041 accgcaggat tgcgttcata cttggatgag ctgtacggca cgtcagtatc ggctgatctt 1631101 acgaaaaaag gagagcggca tgtcattacg ttcaggcttg aaatcccgaa tgaaaaatat 1631161 ttaaaagacc aaacgccgct tctcgagaaa gggctccagc ttctcgcaga actcgtcttt 1631221 tcacctgctt tggagggaga cgcttttcag tcacaatatg tggctcaaga aaaacggacg 1631281 cttaagcaaa gaatccaagc cgtctatgat gataaaatgc gttattcgaa tttaaggctg 1631341 atacaggaaa tgtgcaaaaa tgatccttac gcgcttcatg tcaatggtga aatcgacgat 1631401 gtcgatgaca ttacggcaga gcaattatac gaaacatacc aaagcgctat ccaaaaagac 1631461 cagcttgatc tatatgttgt tggcgacgtg gacagtaacc aggtacaatc ggcaattgat 1631521 aagtatttca aaacagaaga gcgcactctt ggcatgattg aaaacaatca cgctgatgaa 1631581 aaagttcagc caaaagaagt aattgatgaa gaggatgtca agcaaggaaa actgaatatc 1631641 ggctaccgca ccagcatcac ttatacagat caggattatc ctgctttaca agtgtttaac 1631701 ggattgttcg gcggattctc tcattctaaa cttttcatta atgttcggga aaaagccagt 1631761 cttgcttact acgcggcttc gcgtatagaa agttttaaag gcttgttaat ggtgatgtca 1631821 ggcattgaag tgaaaaattt tgaacaggcg gtttcgatta ttgctgagca attccaggca 1631881 atgaaaaatg gcgatttcag tgagcaggat atagcacaga caaaggccgt tattcgaaat 1631941 caagtgctgg aaacgattga tacagcatac ggtttatctg agtttttata tcagcaggcc 1632001 gctgctcaag tcgagattcc tatcgaagac tttcttgcca atattgagaa tgtcacaaaa 1632061 gaggatatca ttaaagccgg cgaaaagatt cagcttgata cgacttattt cttaaaaggg 1632121 acggagggtg catcttgatc aaaccaatcg aatatgaaca gcttcaggag acgctgtatc 1632181 atgaaaaaat gtccaacggc cttgatgttt acgttttgcc gaaaaaaggc ttcaacaaga 1632241 catatgcggt ctttacaaca aagtacggct cgatagataa ccggtttgtc cctttaggta 1632301 aaaacgagat ggttcacgtg ccggacggga ttgctcactt tcttgagcac aagctgtttg 1632361 agaaagcgga cggagacgtt tttcaagatt tcagcaaaca gggggcttct gccaatgcgt 1632421 ttacgtcatt tacaagaacg gcttaccttt tctcaagcac atcaaatgtt gaacgcaatt 1632481 tagagacgct tatcgatttc gtacaggacc catattttac tgaaaaaacg gttgaaaagg 1632541 aaaaagggat tatcgggcag gagattaata tgtacgacga taaccctgat tggaggcttt 1632601 acttcggggt cattgaaaac atgtacaaag agcatcctgt cagaattgac atagcgggaa 1632661 cagtggaaag catttcacat attacaaaag accttcttta tgaatgctat gaaacgtttt 1632721 atcacccgag taacatgctc cttttcattg tcggccctgt agatcctgaa gcgattattt 1632781 ctcaggtaag agaaaaccag gggaaaaagc cgtatactga tcagccggag atcaaacgag 1632841 aagaagtgaa agagcaagaa gcggttttcc gaaaagaaaa agagatcaaa atgaacgtgc 1632901 agggaccgaa atgccttgtt gggctgaaat ccaaaaatcc gtttaaatta ggcaaagagc 1632961 tcttaaagca tgaactttca atgaacttat tgcttgaagc tctttttggc aaaagctctg 1633021 cccagtatga atcactttat gaaaaaggat atattgacga aacgttcagc tttgatttta 1633081 ctgctgaata tgggttcggt tttgcggcga tcggcggaga tacgcctgag cctgatcaat 1633141 tggctgaaga catttcaagc atgcttttgc gcgccggtga actgattact gctgaaaaga 1633201 ttgaacttgc cagaaagaaa aagatcggca cattcttaaa agcgctgaat tcccctgaat 1633261 acatcgccaa tcaatttacc cgttatgcgt tcttggatat gagcctgttt gatgttgtaa 1633321 cggtactcga gcagattacc ctcgaggatg tccagaacgt aatacaagag gaaatcgctg 1633381 cagacagact gactgtctgc aaggttgttc ctaaatcata aacaaaacat ccctccagtg 1633441 tgaggggtgt ttttctgcgg aaagaaggaa agaggatgaa caaaacagca ctaatcaccg 1633501 gagcaagcgg cggcattggc aaaagcatca gcgaaaccct tgcagctaga ggatacaatc 1633561 tgctgctgca ttacaataca aatcaaaacg cggcagcgga gcttgctgaa aaactaagtc 1633621 agatgtttgg cgtaaatgcg gagatattac aagctgacct gtccgcgcaa gatggagcag 1633681 ataagctgac aagttcaatt gttcagccga ttgatgcgat tgttttaaac agcggacgaa 1633741 gccattttgg gctgattacg gatgtagata acgcaacggt ccaggaaatg gttcagcttc 1633801 atgtggcgag tccgtatatg ctgacgagaa accttctgcc aggcatgatt cggaataaat 1633861 cgggagcgat tgtggctgtc agctcgattt ggggagagac tggagcatcc tgtgaagtgt 1633921 tgtacagcat ggcaaaagga gctcagcatt catttgtaaa aggattggct aaggagctgg 1633981 cgccaagcgg aatcagagta aacgccgtag cgccgggtgc agttgataca aatatgatga 1634041 atcaatttac cccggctgaa aaagaagaga tcgctgatga gattccgatc ggccggctgg 1634101 cccggccgca agaaattgcg gatgcaacag cttttctcct gtctgaaaaa gcgtcatata 1634161 tcaccggcca aattctgtcg gtgaatggcg gctggcactg ctgatccgaa aatattcggt 1634221 gtatagtttc ttttgcgaag gacacaataa tcttgtaact tcacatgaaa tggaggaaac 1634281 aagcatgtca gtattagaaa actgggatag ctggaaaaac ttccttggcg accgtctgaa 1634341 ctatgcgcaa gataaaggta tgagccagga tacgattaca gatcttgcga cagaaatcgg 1634401 cagctacttg gctaatgaag tggaatctaa gaacgagcag gaaaaagtgc tggcagatct 1634461 ttggagtgta gcatcaaaag atgaacagca cgccattgcc aatatgatgg ttaagcttgt 1634521 tgaaaataac agcactcact aggaagagag gggatttttc ctctcttttt tatgttttcc 1634581 tcatcacagc aacattcttc tttctaatta gagaaaaatg ctttatgata aaggaaggta 1634641 aaattttgcc acaatgaagg gggtatatca tttggcaaag ctcgaatggt attttgaata 1634701 tgaaattcaa gtgaaccgcc ccggactgct cggggatatt tcatctcttc ttgggatgct 1634761 ttctatcaac atcgtaacga taaacggcgt cgatctttcc agaaggggaa tgctcctcag 1634821 gtgccgccat atagatcaaa ttaaacgatt agaatcaatc ttaaaaacga tggaaacaat 1634881 taaagtaacg aagcttagag aaccgaggct tcgcgaccgt cttgccgtac gccacggccg 1634941 ttatattcaa cgggatgccg atgacaagaa aacgttccgc tttgaacggg acgagcttgg 1635001 cttattagtc gattttatgg ccgaattgtt caaaaaagaa ggccataaat taatcggaat 1635061 cagaggtatg ccgcgtgtcg ggaaaacgga atcgattgta gcctctagtg tgtgcgagca 1635121 aaaggtggct gtttgtgtca tcaaccttgc tgaagcagac gataagaagc cagctgattg 1635181 ccgatgaata cagcactgaa aatgtcttta tcgttgacgg aattgtgtca acacgaagag 1635241 ggtcagaacg ccatctccag ctggtccgag aaatcatgcg gctgcctgca acaaaagtgg 1635301 tggagcatcc ggacatattc gttcaaaata cagagtatac actagatgac tttgattata 1635361 ttattgaact gagaaatgac cctgatgagg ttattacata tgaacatgcc gaggaacccc 1635421 aaatgtttga tcaatccggg ttttcaagct ttgattttta aaattggaag gtgtttgttg 1635481 tgactgaact aggaatccgg ctcaaagaag ccagagagga aaaagcaatg tcattggatg 1635541 atctccaagc ggcaacaaag attcaaaaaa ggtatttaac cgccttggag gaaggaaact 1635601 atgacattat tccggggaag ttttatgttc gggcattcat caagcaatat gcagaagccg 1635661 ttgggcttga tgcggatcag ctgtttgagg agcataaaaa agatatccct aatacgtatc 1635721 atgatgatgt gtctgaaaag atctccggca tgaatcttca aaaggaaatg ccaaagccag 1635781 catctaaggc gctggagctg ctgccaacaa tacttgttat tctcggcgtg attgtcgtga 1635841 ttgccattgt gtacgcgatc attcaatttg ccaatcacaa aaacagtgat gatcacaatg 1635901 cggcatcaga aaaagcaatt acgcaaagtg agagcaagta cgaaatccct aaagattcaa 1635961 cgctgaaaga gaatcaaaat aacagctctg aaaaagagac agacactaaa aaagaaacga 1636021 aagaaaacga agataagaaa aaagaaaatg acagtgagaa gctggagatt aaagctgctg 1636081 gcactgaagg atcgttaacg acttatgaag tgtccggcgc tgataaaatc gagctggaac 1636141 tgaaggcatc agacagctcc tggattagag tgcgcgatga aaacagcagc tctttaaaag 1636201 aaggaacgct gaaaaaagac gaaacctata aaaaagacat aactgatcag aaacaagttg 1636261 atatccgcac cggatatgca cctaatctga aaataaaaat caacggtaag gttctttcat 1636321 atgaacttga tccgaaaaaa gtgatggcac aaaccataaa gattgtaaat aaaaaggaag 1636381 aaaagtcatc ttaattacca gatgactttt cttcacgtcc gagtatgaaa ttggaggggc 1636441 tttatgttta acttaccaaa taaaatcaca ctagctagaa tcgcattaat cccaatcttc 1636501 atgattatca tgctggcgcc gtttgactgg ggcaggctcg aagttggaga cgaatccatc 1636561 ccggtcgcac atttggcggg ggccattcta tttattattg catctacaac agactgggtg 1636621 gacgggtatt atgcccgaaa attaaatctc gtaacaaact tcgggaaatt tcttgatccg 1636681 cttgcggaca aactgctcgt atccgcagcg ttaattatcc ttgttcaatt tgatctcgct 1636741 ccagcttgga tggtcattgt gattatcagc agggagtttg ccgtgacagg tttaaggctt 1636801 gtcttagccg gaacaggaga agtcgtagct gctaacatgc ttggtaaaat caaaacctgg 1636861 gcacagatta ttgcggtatc tgcattgctt cttcataatc ttccatttga acttgtgtca 1636921 ttcccgtttg cagacttggc gctgtgggta gccgtcttct ttactgtcgt ctcaggctgg 1636981 gaatatttct ctaaaaattg ggaagcgtta aaaacatcta actaagaaag aaggacttcg 1637041 tcatggaatt tccaaaaaaa gcagaaataa ttgcagtcgg ttcagagttg ctgcttggtc 1637101 aaatcgccaa tacaaatgct caatttatca gcaaacagct cgctgaaatc ggggtcaacg 1637161 tattttatca tacagcggtc ggagataacc cggagcggct gaagcaggtc atccgcattg 1637221 ctgaagaacg ctctgacttc attatttttt caggagggct tggacccaca aaagatgatc 1637281 tgacgaaaga aacgattgca aatacgctgg gacgtccgct tgtgttaaat gatgaggcat 1637341 tccaatccat tgaggactat ttcaaacgaa caaaacgcac gatgtcacct aataaccgaa 1637401 aacaggcgct tgtgatcgaa ggctctgacg tgctggcgaa tcactttgga atggccccgg 1637461 gaatgctcac agagcatgaa tcgcgctatt atatgcttct tcctggaccg ccgagcgaat 1637521 tgcgtccaat gtttgaaaac gaggcaaagc ctcttctgct gaaaaagatg ggttcaaatg 1637581 aaaaaattgt gtcaactgtt cttcgctttt tcggtatcgg tgaatctcag cttgaagccg 1637641 atttggaaga tattattgat gcacaaacca atccgacaat tgcgcctttg gcggctgatg 1637701 gagaggtgac gctgcgtctg acagccaaac acgccgatga aaaggaaaca gagcgtctgt 1637761 taaaagaaac agaggccgtt atcttagagc gtgtcggtga atttttctat ggttacgatg 1637821 atacttctct tgtaaaagag ctatctatag catgtaagga aaaaggcata acaatttctg 1637881 cggcagaaag ctttaccgga gggctgtttt ctgaatggct gacggatcat agcggtgcct 1637941 caaaattatt tgccgggggc gttgtttgct atacaaacga cgtgaagcag aatgtgcttg 1638001 gtgtcaagaa ggaaacatta gatcgttttg gggcggtcag caaggagtgc gcatccgaac 1638061 tggctaaggg tgttcaaaaa ctcactggca gcgatatcgg cattagcttt actggtgtag 1638121 caggacctga tgctcaagaa gggcatgagc ctgggcatgt gtttatcggc atttccgcaa 1638181 atggtaaaga agaggttcac gagtttcact ttgcgggctc cagaacgggg atcagaaaac 1638241 gcggcgctaa atacggctgc catttaatct taaagctttt agagcaaaaa taatattttc 1638301 agcacattat cctcctaaga aaacatgatt tctctgatac attatgatat tttgatagga 1638361 atcacgccaa gaaaaaatcc gaatatgcgt tcgctttttt cttggcaaat cccttcaaac 1638421 agggtatagt atatgtagtg gtaacataaa ggaggaaaaa atagaatgag tgatcgtcag 1638481 gcagccttag atatggctct taaacaaata gaaaaacagt tcggcaaagg ttccattatg 1638541 aaactgggag aaaagacaga tacaagaatt tctactgtac caagcggctc cctcgctctt 1638601 gatacagcac tgggaattgg cggatatcct cgcggacgga ttattgaagt atacggtcct 1638661 gaaagctcag gtaaaacaac tgtggcgctt catgcgattg ctgaagttca gcagcagggc 1638721 ggacaagccg cgtttatcga tgcggagcat gcgttagatc cggtatacgc gcaaaagctc 1638781 ggtgttaaca tcgaagagct tttactgtct cagcctgaca caggcgagca ggcgcttgaa 1638841 attgcggaag cattggttcg aagcggggca gttgacattg tcgttgtcga ctctgtagcc 1638901 gctctcgttc cgaaagcgga aattgaaggc gacatgggag attcgcatgt cggtttacaa 1638961 gcacgcttaa tgtctcaagc gcttcgtaag ctttcagggg ccattaacaa atcgaagaca 1639021 atcgcgattt tcattaacca aattcgtgaa aaagtcggtg ttatgttcgg gaacccggaa 1639081 acaacacctg gcggccgtgc gttgaaattc tattcttccg tgcgtcttga agtgcgccgt 1639141 gctgaacagc tgaaacaagg caacgacgta atggggaaca aaacgaaaat caaagtcgtg 1639201 aaaaacaagg tggctccgcc gttccgtaca gccgaggttg acattatgta cggagaaggc 1639261 atttcaaaag aaggcgaaat cattgatcta ggaactgaac ttgatatcgt gcaaaaaagc 1639321 ggttcatggt actcttatga agaagagcgt cttggccaag gccgtgaaaa tgcaaaacaa 1639381 ttcctgaaag aaaataaaga tatcatgctg atgatccagg agcaaattcg cgaacattac 1639441 ggcttggata ataacggagt agtgcagcag caagctgaag agacacaaga agaactcgaa 1639501 tttgaagaat aaaaataaaa taagtttcaa atgatacaaa aggctgagtg aaaaactcag 1639561 cttttttgta ttttgcaaaa aaatgataaa aatattgctt tttttgacaa cttttttagg 1639621 gctttattcg tctaacaaaa cgtgtgcaaa atggaattta ttttgggagg aaaaaatgaa 1639681 tgacaagccc aacccgcaga agaactgcga aacgcagacg gagaaaacta aataaaagag 1639741 gaaaactgtt gtttggtctt ttagcagtga tggtttgcat tacgatttgg aatgctcttc 1639801 atcgaaatag tgaagaaaac gaaccatctc aagaaactgc agcggtttca aataccgatc 1639861 agaaaaaaga ggtcaaaaag aaaactgcca aaaaatcaga ggaacaaatc aaaacagtgg 1639921 atcgaaacca aaaaatcagc aattatttaa aagagatcgg tttcagcgga acagccatga 1639981 ttgtcagaaa tggagaaatc gtaacaaata aaggttttgg ctatgctgac cgtaaacact 1640041 acattcaaaa taatccattg acatcttttt atgtcggttc atcacaaaaa gcgctgattg 1640101 caactgctat tttgcagctt gaggaaaagg ggaaacttca gacaagtgat ccggtaagca 1640161 cgtatttacc tcattttccc aacggacaaa cgattacttt gaagaatctg cttacacata 1640221 catcggggat aaacggacat attgaaggaa acggcgccat tactccggac gatttaataa 1640281 aagatataga acttcaggga atcaaacgtc agccgggcgt atgggactac aaggattcca 1640341 actattctgt tcttgcttat attattgctg aagtaagcgg tgagccctat gaacagtaca 1640401 taaagaatca tatttttaaa cctgcgggaa tgacgcatgc aggcttttac aaaacatatg 1640461 aaaaagaacc ttatcctgcc gtcgggtata agatggaggg cagcaaaaca gttacaccgt 1640521 atatacctga tttatcccag ctgtatggag cgggtgatat ttatatgagc gctatagata 1640581 tgtacaaatt tgaccaagcg ctgatagacg gaaaactgta ttcgcaaaaa agctatgaaa 1640641 agatgtttac gccagggagc agctccacat acggcatggg attttatgtt gctcccggaa 1640701 gctattcaaa ccatggtgtt atgccgggct tcaatatctt gaacagcttt agcaaatctg 1640761 ggcaaaccat tgttattttg ttctcaaaca ttcaaaataa tgctaaattg ggccaagtga 1640821 acaataaaat ataccagctt ctaaatcaag aatgattggc gatcttcttt tggatgaatt 1640881 gcattcggca cgtgaaaaga agactggcct gcaaacgtta agatggcaag cttgacaagt 1640941 atttccgaca catttacaat gaagttgtaa catttgtttt tttaacatga ttgttaaacc 1641001 atttaaactt gacaagggcg atgaacacac tcattccctg tgaaggttct gtatgttgag 1641061 aaaactagac aatgtacatg ccgacacttt ttaagcaaca accaagttca tagcaagagg 1641121 aggtgaaagt atgaccccaa ttatgatggt tctcatctcc attttgctga ttctactcgg 1641181 tttagttgtt ggctactttg ttcgtaaaac cattgccgaa gcgaaaattg cgggcgcacg 1641241 cggtgcagcc gagcaaattc ttgaagatgc gaagcgtgat gctgaagcac tgaaaaaaga 1641301 agctctgctt gaagcaaagg atgaaatcca caaacttcga atagatgctg aacaggaagt 1641361 tcgtgaaaga cgaaatgagc ttcaaaaaca agaaaaccgt ttactccaaa aggaggaaaa 1641421 ccttgatcgc aaacatgagg gaattgataa acgggaagcg atgttggaga agaaagatca 1641481 ttctctgaat gaacgacaac aacatattga agagatggaa agcaaagtgg atgagatgat 1641541 tcgtatgcag cagtctgagt tggaacgaat ttcgagtctg actcgtgacg aagcgaaaca 1641601 aatcattctt gagcgggttg aaaacgagct ttcacatgac atcgccatca tgacaaaaga 1641661 aactgaaaac cgtgcgaaag aagaggcgga taagaaagcg aaaaacattc tttcactcgc 1641721 cttacagcgc tgcgcagcgg accacgttgc cgaaacaacg gtatcagttg tcaatcttcc 1641781 aaatgatgag atgaaaggac gtatcatcgg acgggaaggg cgtaacattc gtacgcttga 1641841 aacgctgaca ggaattgacc tgattattga tgatacgcct gaagctgtca ttctttccgg 1641901 atttgatccg atcagacgtg agacagccag aattgctctt gataaactcg ttcaggatgg 1641961 ccgtattcat ccggcacgga ttgaagaaat ggttgaaaaa tctcgccgcg aggtcgatga 1642021 ctatattcgt gagatgggtg agcaaacgac atttgaggtt ggcgttcatg gcctccaccc 1642081 agatctcatc aagatcctcg gccgcttaaa gttccgtaca agctacggtc aaaatgtgct 1642141 taagcattcc atggaagtcg cattcttggc cggtctaatg gcatcggagc ttggtgaaga 1642201 cgcaaagctt gctaaacgtg cgggtcttct tcacgacatc gggaaagcaa ttgaccatga 1642261 agtagaagga agccacgttg agatcggggt agagcttgcg accaaatata aagagcaccc 1642321 agtcgtgatt aacagtattg catcacacca cggggacgag gagccgactt ccattattgc 1642381 tgtactggta gctgcagcag atgcgctttc cgctgcaaga cctggcgcaa gaagtgagac 1642441 gctcgagaat tatattcgaa gacttgaaaa acttgaagaa atttctgagt cctacgaagg 1642501 tgttgaaaaa tcatttgcca ttcaggctgg acgcgaagtg cgaattatgg tgaagccgga 1642561 ttcaattaat gatcttgagg ctcatcgact ggcgcgagat atccgcaagc gaattgagga 1642621 cgagctcgat tatccaggtc atattaaggt gacagtaatc agagagactc gagccgtaga 1642681 gtatgcaaaa taaagtgatg cgctaagcat cactttattt ttttgacggc aaggaatttt 1642741 caagaagaaa ggatttacaa aatgagaatt ttatttatcg gagatgttgt cggttcaccg 1642801 ggccgtgaca tggtcaaaga atatgtacca aagctaaaaa caaaatataa gcctcacttt 1642861 accattatta atggtgaaaa cgccgcacat ggaaaaggcc tgacggaaaa aatttatcac 1642921 agcttaatcc agtccggcgc agatgcaatc acaatgggga accacacatg ggacaaaaaa 1642981 gaaatatttg attttataga tgacgttccg aacttggttc gcccggcaaa ctttcctgaa 1643041 ggaacaccgg ggaaagggat cacatatgtg aaagcaaacg gcaaagaact agcagtcatt 1643101 aatttgcagg gacgtacgtt tttgccgccg cttgatgacc cgtttttaaa agcggatgaa 1643161 ttgatcgcag aagctgcgaa aagaacaccg tacattttta ttgactttca tgccgaagcg 1643221 acaagtgaaa agctcgcact tggctggtac acggatggac gggcatcggc tgtagtagga 1643281 actcatacac acgtgcaaac agcggataac cgcattttgc cgaagggaac ggcatatatt 1643341 actgatgtgg gaatgactgg cccgtatgac ggtatactgg ggatggacag agagacgatt 1643401 attaagcgat tcaaaacgaa ccttccagtc cggtttactg tcgctgaagg aaaaacaacg 1643461 ctcagcggag ttgtcattga cattgacgat caaacgaaaa aagccgtgaa aattgagcgt 1643521 attttaatca acgatgatca catgttcttt gaatagttga acatatggtt attttataaa 1643581 aatattaaaa agaaaagcag gaatatagca actccttagt gaatatagta aaaatggaag 1643641 gtagcccgct atttttgaaa agcattgtgg ggatggcttt ttggatagca acatctaata 1643701 atgattgttc taatgaacac tcacttatcc attgtaaaac taagggggag cagaaatgga 1643761 aatcttaaaa gtttcagcaa aatcgagtcc aaattcagtg gcaggtgcgc ttgcaggcgt 1643821 gttgagagag cgaggagccg ccgagattca agcgatcgga gcgggtgcat taaaccaggc 1643881 tgtaaaagct gtggcgattg ccaggggatt tgtggcgcca agcggcgttg atttgatttg 1643941 tattccggct tttacagata ttcaaatcga tggggaagaa agaacagcga ttaaattaat 1644001 cgtggagcct cgctaaaaac aaataaagca ttctcaacct gtttgcgtaa tgcaaacagg 1644061 ttgtttttca tttattgtga tattttctcc cgatagtatt tttagcacat aaatgagcga 1644121 atatacaaaa tcagaaatga gctaaaacgt ttcaaaaaaa atttccgccc atttttcaag 1644181 acagatactt ttgtccttct ggaaaagaca gttctgttta cgcttattcc atatcatggt 1644241 acaatccgaa tataacaaga atttttcaag gaggattgta catgcagagt ggaaagatga 1644301 aagctctaat gaaaaaggac ggggcgttcg gtgctgtgct gactgaagtt cccattcctg 1644361 agattgataa acatgaagtc ctcataaaag tgaaagccgc ttccatatgc ggcacggatg 1644421 tccacattta taattgggat caatgggcac gtcagagaat caaaacaccc tatgttttcg 1644481 gccatgagtt cagcggcatc gtagagggcg tgggagagaa tgtcagcagt gtaaaagtgg 1644541 gagagtatgt gtctgcggaa acacacattg tctgtggtga atgtgtccct tgcctaacag 1644601 gaaaatctca tgtgtgtacc aatactgcta taatcggagt ggacacggca ggctgttttg 1644661 cggagtatgt aaaagttcca gctgataaca tttggagaaa tcccgctgat atggacccgt 1644721 cgattgcttc cattcaagag cctttaggaa atgcagttca taccgtactc gagagccagc 1644781 ctgcaggagg aacgactgca gtcattggat gcggaccgat tggtcttatg gctgttgcgg 1644841 ttgcaaaagc agcaggagct tctcaggtga tagcgattga taagaatgaa tacaggctga 1644901 ggcttgcaaa acaaatggga gcgacttgta ctgtttctat tgaaaaagaa gacccgctca 1644961 aaattgtaag cgctttaacg agtggagaag gagcagatct tgtttgtgag atgtcgggcc 1645021 atccctcagc gattgcccaa ggtcttgcga tggctgcgaa tggcggaaga tttcatattc 1645081 tcagcttgcc ggaacatccg gtgacaattg atttgacgaa taaagtggta tttaaagggc 1645141 ttaccatcca aggaatcaca ggaagaaaaa tgttttcaac atggcgccag gtgtctcagt 1645201 tgatcagttc aaacatgatc gatcttgcac ctgttattac ccatcagttt ccattagagg 1645261 agtttgaaaa aggtttcgaa ctgatgagaa gcgggcagtg cggaaaagta attttaattc 1645321 cataaagggg gataaacatg acgaaggaat ttgagttttt aaaagcagag cttaatagta 1645381 tgaaagaaaa ccatacatgg caagacataa aacagcttga atctatgcag ggcccatctg 1645441 tcacagtgaa tcaccaaaaa gtcattcagc tatcttctaa taattacctc ggattcactt 1645501 cacatcctag actcatcaac gccgcacagg aggccgttca gcagtatgga gccggcaccg 1645561 gatcagtgag aacgattgcg ggtacattta caatgcatca agagcttgag aaaaagctgg 1645621 cagcctttaa aaaaacggag gcggcacttg tattccaatc aggcttcaca acaaaccaag 1645681 gcgtactttc aagtattcta tcaaaagagg acattgtcat ctcagatgaa ttgaaccatg 1645741 cctctattat tgacggaatt cgactgacaa aggcggataa aaaggtgtat cagcacgtca 1645801 atatgagtga tttagagcgg gtgctgagaa agtcaatgaa ttatcggatg cgtctgattg 1645861 tgacagacgg cgtattttcc atggatggca acatagctcc tctgcctgat attgtagagc 1645921 tcgctgagaa atatgacgca tttgtgatgg tggatgacgc ccatgcatcc ggagtacttg 1645981 gcgaaaacgg caggggaacg gtgaatcact tcggtcttga cggcagagtg catattcagg 1646041 tcggaacatt aagcaaggca atcggagtgc tcggcggcta cgctgcaggt tcaaaggtgc 1646101 tgatcgatta tttgcgccat aaaggccgtc catttttatt cagcacatct catccgccgg 1646161 cagtcactgc agcttgtatg gaagcgattg atgtcttgct tgaagagccg gagcatatgg 1646221 agcgcttgtg ggagaatact gcctatttta aagcaatgct tgtgaaaatg ggtctgactc 1646281 tcacgaagag tgaaacgccg attcttccta ttttaatagg tgatgaaggt gtggcaaagc 1646341 aattttcaga tcagctcctt tctcgcggtg tttttgccca aagtatcgtt ttcccgactg 1646401 tagcaaaggg aaaagccaga attcgcacga ttataacagc agagcacacc aaagatgaac 1646461 tggatcaggc gcttgatgtc atcgaaaaga cggcaaagga gctccagcta ttgtaacaag 1646521 aggaagagtt tactcttcct cttttgattc cttattgatt attattctca atgagtgtac 1646581 aatgataggt tgccagttgt gcagagcttc aataaccttt atactgaagg gtggaagttt 1646641 ggtttgaaag gagaaaatat gacatgaatg aaaaacaaaa attagagagc ggacaagttc 1646701 atccatcgga caaaaaatcc gagaaggatt acagcaagta ctttgaagct gtttacattc 1646761 cgccttcttt aaaagacgcg aaaaaacgag gcaaggaagc cgttacttat cataatgact 1646821 ttaaaatttc tgaacaattt aaaggattgg gagacggaag aaagttctat atccgtacgt 1646881 acggctgcca aatgaatgaa cacgatacag aggttatggc agggatcttt atggcgctcg 1646941 gttacgaagc gacaaactct gttgacgatg ccaatgtcat tttgttaaat acatgtgcaa 1647001 tccgtgaaaa tgctgaaaac aaggtgtttg gtgagctcgg gcacttaaaa gcactgaaaa 1647061 aaaacaatcc cgatctgatt ttaggcgtgt gcggctgtat gtcccaagag gaatcagtcg 1647121 tgaaccgtat tttgaaaaaa catccgtttg tcgatatgat tttcggaacg cataacattc 1647181 atcgcctgcc ggagcttttg tcagaagcat acctttcaaa agaaatggtt gtagaagttt 1647241 ggtctaagga aggggacgtt attgaaaacc ttccaaaagt ccgaaatgga aaaattaagg 1647301 gctgggtcaa tatcatgtac ggctgtgaca aattctgtac gtattgcatt gtgccttaca 1647361 cacgcggaaa agaaagaagc cgccgccctg aggatatcat tcaggaagtg agaaggctcg 1647421 caagtgaagg ctataaggaa attactctgt taggccaaaa cgtaaacgcg tatggaaaag 1647481 actttgaaga tatgacgtac ggacttggtg atttgatgga tgaactgaga aaaatcgata 1647541 tcccgagaat ccgttttaca acgagtcatc cgcgcgactt tgacgaccgc ctcattgaag 1647601 tgctggcaaa aggcggaaat ctgcttgatc acattcatct tccggttcaa tcaggaagct 1647661 cagaagttct caagctgatg gcccgcaaat atgacagaga gcgttacatg gagctggtgc 1647721 gaaaaattaa agaagcaatg ccaaacgctt ctttgacaac ggacattatc gtcggatttc 1647781 caaatgaaac ggacgaacag tttgaagaaa cgctttctct ataccgtgaa gtggagtttg 1647841 acagcgccta tacgttcatt tactctccgc gtgaaggcac tccggctgct aagatgaaag 1647901 ataatgtacc gatgcgtgtg aaaaaagaac gcctgcagcg tctaaacgca ctggtgaatg 1647961 aaatttctgc taaaaaaatg aaggaatacg aaggcaaggt tgtcgaagta ttagttgagg 1648021 gtgaaagcaa aaataaccct gatattcttg ctggctatac tgaaaaaagc aagcttgtca 1648081 atttcaaagg gccgaaggaa gccatcggca aaatcgtccg cgtgaaaatc cagcaagcga 1648141 aaacatggtc gcttgacgga gaaatggtag gagaagcaat cgaggtgaaa tgagatgacg 1648201 ctctactcaa aaaaagacat tgtgcagcag gctcgaaacc ttgcaaaaat gatttctgaa 1648261 acagaagagg ttgatttttt caaacgggct gaagcgcaaa tcaatgagaa tgacaaagtg 1648321 tccacaatcg ttaatcagat taaagccctg caaaagcagg ctgtcaatct gaagcattat 1648381 gaaaagcatg aagcgctcaa acaagtagaa gcaaaaattg acgcgctgca agaagagctt 1648441 gaagagattc ctgttatcca ggaattcaga gactcgcaaa tggaagtaaa tgacctactg 1648501 cagctcgttg cacacaccat ttccaaccaa gtcacaaatg aaatcatcac atcaaccgga 1648561 ggcgacctgc tgaaagggga aaccggttca aaggtgaagc attcaaataa cagctgttct 1648621 ctctaaacac ggtgccttta caggcccgtg tttttttatc atttgtgcgg ttaaaaatga 1648681 actaaataat ctatgtacca aatgttcaat tggtttttct gtgctcagcc gcgtataaac 1648741 tttatcgcac ttataagtaa agtttctagg cacccctgca tacaatggaa cagaaacttt 1648801 gtatttttat attttattta taaaaatgca cactagacaa atgcccagca taagataaca 1648861 cgaagaagaa caaggaggca tgccggaatg tctgaataca gggaaattat tacgaaggca 1648921 gtagtagcga aaggccgaaa attcacccaa tgcaccaaca ccatctcgcc tgagaaaaaa 1648981 ccgagcagca ttttgggtgg ttggattatt aaccacaagt atgacgctga aaaaattgga 1649041 aaaacggtag aaattgaagg gtattatgat ataaacgtat ggtactctta cgcggacaac 1649101 acaaagacag aggttgtcac agaacgggta aaatatgtag atgtcattaa actcagatac 1649161 agagacaata attacttaga tgatgagcat gaagtgattg ccaaagtgct tcagcagcca 1649221 aactgccttg aagtgaccat ttcgccgaat ggaaataaaa tcgttgtgca ggcagaaaga 1649281 gaatttttgg cggaagtggt aggggaaaca aaggtagttg ttgaggtcaa tcctgactgg 1649341 gaagaggatg acgaggaaga ttgggaagat gagcttgatg aagagcttga agacatcaac 1649401 ccggagtttt tagtgggaga tcctgaagaa taaaaaaggg actaggggag acagtacccc 1649461 caagtctctt ttttatattg atatatcatt cttttatcac tttttgttta tgttataatg 1649521 aaggttggaa aatagaaacg ttgatacata gtgagggatt aaacaatggc cggttatacg 1649581 cctatgatac agcaatattt aaaaataaag gcagagcacc aggatgcctt tttatttttt 1649641 cgcctgggtg atttttatga aatgtttttt gaggacgcca aaaaagcgtc acaagagctg 1649701 gaaattacgt taacgagcag agacggcggt gcggctgaaa aaataccgat gtgcggtgtg 1649761 ccgtatcatt ctgcttccgc gtatatcgaa cagcttatta aaaaaggata caaagtggcg 1649821 atctgtgaac agacggaaga tccgaaagcc gcaaagggcg ttgtgaaaag agaagtagtt 1649881 cagctgatta cgcccggaac tgtaatggac ggcaaaggca tccatgagtc ggaaaataat 1649941 tttatcgcat ctgtttcagc ctgctcgaac ggatacggac ttgctctgtc tgatttaaca 1650001 acgggagaaa atttggctgt tttgattgaa cggcttgaag acgtcatatc agaaatttat 1650061 tcagtcggcg cacgggaaat cgtggtttca ggaagcttgg atgccgatac agtggcacag 1650121 ctgagagagc ggtgcggtgc aacgatttca attgaagacg gagaaacaga cgaacacgta 1650181 acgatcattg agcacttaaa taatgaagat ataacaaaaa catttctgcg cttatatacg 1650241 tatttgaaaa gaacccaaaa gcgcagcctt gatcatcttc agcccgtgca ggtgtatgag 1650301 cttgaggaag cgatgaaaat tgacttgtac tcaaagcgta atctggagct gaccgaaacg 1650361 attcgttcga aaaataaaaa aggctccctt ttgtggctgc tggatgaaac aaaaacggca 1650421 atgggaggcc ggctacttaa acagtggatt gaccggccgc ttatcagagt caatcaaatc 1650481 gaagagcgcc aagaaatggt ggaaacatta atgtcccatt tctttgaacg ggaagatctg 1650541 cgtgaacgtt taaaagaagt atatgactta gaacgccttg ccggccgcgt tgcattcgga 1650601 aatgtcaatg cccgggattt gattcagctg aaggaatcgt taaagcaagt gcctggcatc 1650661 aaacagctgg ttgcttcact ggctcatgac aaggccaagg aacgtgcaaa gcgcattgac 1650721 ccttgcgggg atgtacttga actgctggaa gaagcgctgt acgaaaaccc tcctttatcg 1650781 gtaaaagaag ggaacctgat taaagatggt tataatcaaa agcttgatga atatcgtgat 1650841 gcaagcagaa acggaaaaga ctggattgcc cgcctggaac agcaggagcg ggaatacaca 1650901 ggcattcgct ctttaaaggt cggctttaat aaagttttcg gttattacat tgaagtgaca 1650961 aaagcaaact tgcatttgct tgaggaaggg cgttatgagc ggaagcagac gttaaccaat 1651021 gcagagcgct acattacacc tgaattaaaa gaaaaagaag cgctcatttt agaggcggaa 1651081 aataacatct gtgagctgga gtacgagctg tttaccgagc tgcgcgagaa agtgaagcag 1651141 tatattccgc ggctgcagca gcttgcaaaa cagatgagcg agctggacgc actgcaatgc 1651201 tttgcgacaa tcagtgaaaa tcgccactac acgaaaccag agttctctaa agatgaagtc 1651261 gaagtgattg aaggcagaca cccggttgtt gaaaaagtca tggacagcca ggaatatgtc 1651321 ccgaacaact gtatgatggg cgataacaga caaatgcttc tcattacagg tccaaacatg 1651381 tcagggaaaa gcacgtatat gagacaaatc gcgctcattt ccattatggc gcaaatcggc 1651441 tgctttgtac ccgcgaaaaa agcggtgctc ccgattttcg atcaaatttt tacgcgaatc 1651501 ggcgctgcag atgatttgat ttccggacaa agtacattta tggtagaaat gcttgaagcg 1651561 aaaaatgcga ttgtcaatgc gacgaaaaac agcctcattc tgtttgatga aatcgggcgg 1651621 ggaacgtcca cttatgacgg catggcgctg gcacaggcga ttattgaata tgttcacgat 1651681 catatcggcg ccaagacgct gttcagcaca cactatcacg agctgaccgt tcttgaggac 1651741 aagctgcccc agctgaaaaa cgttcatgtt cgcgctgaag aatataacgg aacggttgtc 1651801 tttcttcatc aaattaaaga aggtgcggct gataaaagct atggtatcca tgtagctcag 1651861 cttgccgaac tgccgggaga tctgattgcg cgcgctcaag atattttaaa agagcttgag 1651921 cattcaggaa acaaaccgga agtgccggtg cagaaacctc aggtgaaaga agagccggca 1651981 cagctgtcct tttttgacga agcggaaaag ccggctgaaa caccaaagct ttcaaaaaaa 1652041 gaaaagcaag tgatcgatgc tttcaaatca cttaatatac tggatatgac accgcttgaa 1652101 gcgatgaatg aaatgtacaa gctgcaaaag aaattacatt aaaacggggt gatgaatgtg 1652161 gcaaaagtca tccaactgtc agatgagctt tcaaataaaa tagcggcggg cgaggttgtg 1652221 gaacggcccg cctcagtcgt caaagaattg gtggaaaatg cgatcgacgc tgacagcaca 1652281 gtcattgaaa tcgatattga ggaagcaggc cttgcatcca ttcgggtctt ggataacggc 1652341 gaaggaatgg agaatgaaga ttgcaagcga gctttccggc gccacgcaac gagtaaaata 1652401 aaagatgaaa atgatttatt cagggtgaga acgctcggtt tcaggggaga agccctgccg 1652461 agtatcgcgt cagtctctca tctggagatt acaacaagca ctggtgaagg agctgggacg 1652521 aagctcgtcc tccaaggagg aaacatcatt tccgaatcgc gttcctcaag caggaaggga 1652581 actgaaattg tcgtttccaa cctgtttttt aacacaccgg cccgtttgaa atatatgaaa 1652641 accgttcata cagagcttgg aaacattaca gatgtggtta accgtattgc tctggcgcat 1652701 ccagaggtat cgatccgcct gcgccatcat gggaaaaacc tgcttcaaac gaacggaaac 1652761 ggagatgtgc gccatgtact ggcagcgatt tacggcacgg ctgtcgccaa aaaaatgctt 1652821 ccgctgcatg tgagctcctt ggattttgaa gtaaagggat atatcgccct cccagagatt 1652881 acacgggcgt cgagaaacta tatgtcgtct gtggtcaatg gccgttacat taaaaatttc 1652941 ccgctcgtca aagcggttca tgaaggctat catacgcttc tgccgatcgg acgccatccg 1653001 attactttta tagaaattac gatggacccg attttagtcg atgtcaacgt gcatccatcg 1653061 aagcttgagg tccggctcag caaggaaaca gagcttcatg acttaatacg tgacggaatt 1653121 aaagatgtgt ttaaacagca gcagctgatt cctagtgccc aggtcccgaa aaaatcagca 1653181 cctgccatca aaaatgagca gcagtttata acctttgatg aaaagcctcc ggaaaaaaaa 1653241 gttccggaaa aatcgactgc gccatcttat tcaccgatga agctcagctc agtcgtaaaa 1653301 gagccggttg atgcggagga aaaattgccc cctctccaat ttgatgctcc tcctatcgtt 1653361 gatcaggaac aaacccttga ggtgtccgat gtttcagcag aacagcctga aacatttgag 1653421 caggaatgcc atgaggaaca gccgcagcca gcgtctgatc gggttccaat tatgtacccg 1653481 attggccaga tgcacgggac ttatatattg gcacaaaacg aaaacggcct atatattatc 1653541 gaccagcacg ccgcccaaga acgtattaaa tatgagtact tccgtgaaaa ggtgggggag 1653601 gttgagcctg aggtgcagga gatgattgta ccgctgacgt tccactactc cacaaatgag 1653661 gctttgatta ttgaacagca caaacaagag ctcgaaagcg tcggtgtctt tttagagtca 1653721 ttcggctcta acagttacat cgtccgctgc cacccagcct ggtttccaaa gggagaagaa 1653781 gcagagctta tagaagaaat cattcagcag gtgctcgact ccaaaaatat agatattaaa 1653841 aaacttcgcg aggaagcggc gattatgatg agctgcaaag gctccatcaa agcaaatcgc 1653901 cacctcagaa acgacgaaat caaagcgctt ctggacgacc tccgaagcac atcagaccca 1653961 tttacatgcc cgcacggccg cccgatcatc attcaccact cgacatatga gatggaaaag 1654021 atgttcaaac gcgtgatgta gcgggggtgg taggcattga tccattctct gaatggatca 1654081 atgctttttt tgtactcctt cgagtgtcag attataagaa acggttgtaa acgtgtgagc 1654141 agtgttaacg cattatactt catggttcct ccgtataaca aaatttccat ttacaggcaa 1654201 ttgggattaa tgtatatttt gggtgagggg gtggaaacat atggcatgtg gtccgaagat 1654261 cattatcttt ttggatgaac ttgatgatcc aaatgtgaga atcattttag aatgcagaat 1654321 ttaaattaca acattgtgtt ttgctccctg ttcgtgtgaa cagggagatt ttttcgttta 1654381 tataactggt gatgtccaaa tatagggtgt tatgaatttt ccatatctgc catcggcttt 1654441 aagctgcttc tctattaggc tggttatcaa aagcaagttc aatgatagcc atgaaagctg 1654501 atatcacaac aagcaagaca tctggaatat aaatagactg cataaagtaa tctgcaaaac 1654561 agatcgttat aagattgctg ataaaataca gtataaaagc aaaaagtgca gtctttttca 1654621 atgaaagtga ttttgccaaa atgatagaga taatctttgt gagtgggtct atgattaaac 1654681 ctacagcaaa gcaggctaaa ataaataaag ctaatgtttg attggaagcg tatgtgatgc 1654741 caagtatgga gaataagcct ttcatcccga agaaaaagcc gccgaagatg actgcaagcg 1654801 cgatggccgc gataaaagta atagatacaa ttccgattaa ttttgatctc aggttaaaat 1654861 ctttagagtg ctcgttctgt tctttttggt tcatgtatga cactcccttc acctgcttac 1654921 tcatacaaac agcacccttg aatcagccca aaatatctat aagtctgttt tctgacgaaa 1654981 atagtatagc atattttaac aaaaccaaaa aaggcccttt ccactgggga agggcctttt 1655041 tcatcatgtt aactcctgag attcgccgaa gctttctctt tttttggcca aataaaatag 1655101 ctggctgtaa tgagaaagtc aatgcctata atgacagtcc acagtttaag aatgccgctc 1655161 aacgcctcgg ttcgggaaga gtcattgata aaatagatca tccctgccaa tagtcccgca 1655221 ccaattaagt aggccagcac atgtcttagc cagcctttcg caccgtgctt ggcatggtcc 1655281 attccaaaac gtttcagcgg ttttgttcct ttttttgtca cataatattg aaacttttca 1655341 tctgcccatt gaatcatttg tttcccataa gcgatcgata taccgatgta aacagctgca 1655401 atcccatggg ctgcggtcgc tgaggctccg cggtaaaggt ccacaccagt tgccgctaac 1655461 aagatcaaat cgataactgg agttaaggca aggaatagca gtcctaatgt atgtcgtttg 1655521 aatacgtagc gtacagcaag ccccaaaaca atgacaaccc aaaacgcaat ttcacagaaa 1655581 acaatcatcc atgcgatacc gttcaatcca ttcccctctt ttcaatacag ttgtattatt 1655641 taaataatat gttaccatct ttgtttttgt aacacaactg tattataaaa attgccccgc 1655701 ctttgaacga aagctcaaag gcgctacgct gtattatttt gatgaaagtg gctgtcagct 1655761 gtgctggata tcaattgtat atactgcacg atctgttacg accttcaatc cttcgttttc 1655821 ttggtgaata tgaagctcac ctaataaagg aatctcatag gcattttgcg gaagcggtac 1655881 gtttccgtcc tcagtgaatg ttgttccttc gccttctaaa acaagctctt ctttcgcaac 1655941 ataatcatca ggatgattcg tactgcgtat agccactttt tgaaggtgga gaacaatctg 1656001 atccaagtct gatatctctt catcatgggt caattcacct tttctaatat caagcgtctg 1656061 gccgactttt gattccagcc attgagaaag ctgtgtattc gtgtgtgcca tcaatattcc 1656121 tccttttgat ctacacgata ctattcccaa ttgctgcatc ttttacacgg gaaagagccg 1656181 ccccactctt tatgtatgaa acagttcgct gttgagtgcc ttgatatagc gtacggcaga 1656241 acgctggacc gattcgtcgg cattttcttt gacaacttta gagaaagcat tgtaaagccg 1656301 gttgaattga agcggtttta ctttggctgc tatttcttca actttggagg cgggaagggg 1656361 aatgagattt gggtagctgt acataaagct gacccagttt cgatccgccg caaccgtaat 1656421 gatatctccg gtcaatagac agcctttccc ttcattgccc ttgctccaat gcaaaacagc 1656481 accgccttta aaatgtccgc ccagtcggta aaggtccagt cccggcttca tattgagcgt 1656541 ttcccctgac cagaagtgaa tgtgattgct tggccttgtc acccattctt tatcatcctc 1656601 atggatatag atcggcgcct gaaacgcttc agcccactca acctgagtag agtaataatg 1656661 tggatgagac aaggcgatgg cttgaatacc gcctaattcg ttgatttggt caattgtctt 1656721 ttggtcaaga tatgtcatgc aatcccacag cacattgaag cccttatgct gaataagatg 1656781 ggctgtttgt ccaatcgcaa actctggttc agttttgatg ctgtaaagat gctcttcttc 1656841 ctttttaagg atgttttgaa ggtttccttt ctcacgcatg tcttcaaggg ttgtccaagt 1656901 ttgtccatcg ggatgaatat actgtctttc atcctcgcaa atcagacacg agttgggcgg 1656961 atctacagtc tgtgcatgtt gcacaccgca tgtattgcag atataatatg gcactttctt 1657021 cacttccttc atctattttc cattatttta ccttatgatt atgaatattc aaacgaaaaa 1657081 accggcagtt ctgctgagag agaattgccg gcttttgatg atgtttattg gccgggaacg 1657141 gaattttctg cgttgacagc gcccgctccg tagatattcg gatcttcatc tttccatttg 1657201 tccgtgccgt ttttcaaaag ctcttttact tcatcagggg taagatccgg gttttgctga 1657261 agaattaaag ctgcgattcc tgcgcaaatc ggtgttgcca tcgaggttcc tgacattgta 1657321 aagtactgag accctacacg gcttgacttt tggagcttat caatataaga attcggagag 1657381 cgaagggaaa taatattaac acccggcgct aaaatatcgg gcttttcttt cccgtatact 1657441 gtcgggccgc ggcttgagaa ggaagcgaca gtatcatcat cgctgcttgc agtattgtta 1657501 tcgtcaagcg cacctactgt aatcaccttt tcgctcacgc ccgggcttgc aatggtctgc 1657561 gaatcagggc ctgagtttcc ggcagcgaca cagacgacaa tccctgcgct ccacgcttcc 1657621 tcaaccgctc tgactaacgg atcttcctgt tcatgatcat atctaagggc atcgcccccg 1657681 agcgacatgc tcataatatc aatcggttca tcggggttgt cctcattgta ttgaatacac 1657741 cactcaacac cctctataat atctgctaac gttcctgaac cctgcttgtt taataccttt 1657801 acgccgatga gattggcttc cggtgcaggt ccgcggtatt gaccggaaga ggatgcaccg 1657861 ctgcttgcga catcacctgc acagtgtgtg ccatgaccat tatcatcgta cggctctgtt 1657921 ttttgattga ccatgtccgc gaatccgata attcttcctt ctagatcagg atgcgggtag 1657981 attcctgtat cgacaacagc gacagtaaca ccttttcctg tcagggtttg cccgtttctg 1658041 acgacttcct tcgcatggct tgcttcggtt gccgtgtcta aaagcgcttt gacttcgcgg 1658101 tttaaataca ctttacggat attgctgcat tcagagagaa gggaatgtaa tgctgaagga 1658161 gtaacctcgg cgctgcagca gttgattttg ttgaagcggc tttttagctt gctgcgtttt 1658221 tctttttgca gcacctctcc agccatttga aagccggtct cgtgacagcc ttcctcaaat 1658281 tcgataatga ctgacatttt ttttctgttt tgcaatttgg tttcgaaaaa tttatgcaag 1658341 aagcaaggag tccatttgaa gggcttgtaa agttgcaata cggtttcccg taacggccaa 1658401 tctagcttgt gagcatttgc tctcaccatt tgtaccatag agtacccaaa catgtatttt 1658461 cctcctatta taaggttctc tgtatactct atgaacagat gataggtttg gtaagtttgt 1658521 ttgtcctctg taagagacag acaagagttt gtttttctga atctttcgca ttagatacga 1658581 tagattcaga agctgaggaa atcattgggg attgaaaaag aacgtttgtt cgtattataa 1658641 tgtgatcata tcaaactggg aaggggagag caaccgtatg aatttctact tgcaccgatc 1658701 tttggaaagc caaatgccaa tcagcattat atatgaagaa agacggaacg attagtaaaa 1658761 gaacgattat tgtgagacag aaaagcaaaa cgaaaatcaa agcattttgt ttttcgaaac 1658821 aacagatcag aacattttta ttggactcta tcctctcctg tgattttgtg agaacaaata 1658881 agcaaaatct ctattctgca ggccggtaac agctgtccgt ctcagcaacc gggcagcctg 1658941 ttactaaaac cctccttaaa cctatataca tttatttgcc aagtgaggtt gttcctacct 1659001 tttttgtctt tcctctcaac cttttttcac tcttatttga aatgaaccgc taataaccgt 1659061 gacaatcaat tgattttttg aaaccgggaa ctttttcact gatgatattg tgtatacaat 1659121 ggtaagataa aacctattgg ctaaacctca tataatgaac cgcgccattc ttatgaaagg 1659181 agttaaacat gagaagattt ttactaaatg tcatattagt cttagccatt gtcttgttct 1659241 tgagatatgt tcattactca ttggaaccag aaccatcaaa tcagccagat acatattcaa 1659301 atttcagcag cttggcagag aatgagagcc cagccgatta cgatatttca tataatgaga 1659361 aaaaaggaag caaagtctta attatgtctc cgcatggcgg aagaattgaa ggcggagtaa 1659421 gtgagcttgt gcgttatttc aataatgaat actctacata cctatttgaa gggttgaagt 1659481 cccatgataa ccaaacactg cacattacaa gcaccaactt tgatgagcca ttggcaaaaa 1659541 agaaaatcaa ggagcatcaa tatgtggtgg cttttcacgg atataaagga gagaacaaga 1659601 atacccttgt agggggaaca gaccgaaagc gggcgaaaat gattgtgaga gcccttgagc 1659661 ggagagggtt ttccgctgag ttagcgtcgt ctaaaagcgg tcttgctgga ttgaatgccg 1659721 aaaacattaa taaccaaggg gaaacggggc taagtatcca gctggaaatc agccgtgagc 1659781 agagagaagc attttttgat gatttttatt ataaaaatag aaaatacaca aagaacagtg 1659841 aattttatgc ttatgtcagt gcgatcaaag gtgtcctgga aaaagagtat tcgtaacaag 1659901 cagatcagaa gacaaaataa gagaagatca gtagactgaa ataggataaa aaaggaggca 1659961 aaacaatggc agatcatcat ttttatttaa aagcgaactg gccgggtaac cgtaatgatg 1660021 tcggtacgat cgaaagcgga aacctgatca catcgatttc cattcctaaa gaaatggatg 1660081 gcccgggaga agggaccaac ccagatgaaa tgcttctcgg ggcggcagcg acctgttaca 1660141 ttattacact tgcagcgatg atggagagaa gcgggctgga aaaagaagac ttacagatgg 1660201 agtcagaagg cattgtcaac gttacaaaag gagtctttac atacaaaaag atcattcacc 1660261 gtccctctgt cgtgcttaaa catgatgctt cacaagacga cgtcgcattg gcgcacaaac 1660321 tttgtaaaaa agcggagtcg tcatgcatga tttcgcgtgc aattcaagga aatgtcgagc 1660381 tgcagcttga agcctctgtg aaactgggtg gagaataaag aaaacagacg gtcactcaca 1660441 ggccgtctgt tttttatctt cagcgtgggc tttcgattga tttagcacga ccacgcctgc 1660501 aatgacaagc gtgagaccga atacaccttt taaactgatg gtttcgccaa aaagcaaaaa 1660561 cccgacaatt gctgtaagcg cggtaccaac gcccgaccat gttgcatacg cgcttgataa 1660621 gtcaattgtt tttaaagaaa agcttagaaa cgtaaaagca gaaagaaatc cgactatgac 1660681 tccggcaatg ggccaggctt gtgtaaatcc ttctgaaagc ttcaacatcg tgctcccaaa 1660741 cacttcagat acaatggcga gagccaaata aagcaatcct ctcatcttca tcactccttt 1660801 acggccaatt aagtaacacg acccctgata gtaataaaag aatcccgata agccctttgg 1660861 cattcagatc ttccttgaac cattttactc cgatcactgt cgtcagcacc gtgcctgccc 1660921 cgctccaagt cgcataggag aggctcaggg gaatatggtt taaagtcagg gacagcatat 1660981 aaaaggcgag ggaatagcca ataacgacca aagcacttgg cttccacttt ttgaagccat 1661041 cagatacttt cagcatggct gctcctatcg attccgaaca tatggcaatc gtgaggaata 1661101 tatatcctat caacatcatg aattctcctc actatatttt tagattagaa aaaaaacttc 1661161 agctagaaaa atattagtgt atgcctatgt atgagtcaag agattcattt tcacacactt 1661221 aaaaagaccc ctttttaagg ggtcttttgc gtttaataat aaaaagggaa cggggcatac 1661281 ggataatagg ggtatccgcc atacaaataa ggattaaata aagcgcttcc tataagcccg 1661341 cctgcaaggc cgccgataaa cggtcctcca aaaaatccga atggccggcc aaacccataa 1661401 ccaaatccgg gtcttccaaa cccgtaaccg aacccgaacg gtcttccaaa cccaaatggt 1661461 ctcccgaatc cgaacggcct tccaaatatt cttgtatctt cagggctgaa atgctctaac 1661521 tcgttcatgt tttctttcct cctgtaataa agtgtagatg atgcagtgta ttcaccctgc 1661581 ccggatttga ttgggcgaat cgaggaaaag gaggatgtga acacattggg cctgtatcag 1661641 tctgactggt caaaagcacc gccccacgca catgcttatc atgtcaaaac aacgagagaa 1661701 cagggccatt atcatctcat cgaagggttt actcagccgg caaacggatc aaataccgat 1661761 cagcatacac attactatac agggatcact tcatttgaaa acggccattt tcatcggtat 1661821 tacggaatct caggaccggc gattccctta gcagatggca cacattatca tgaaatcgaa 1661881 gaaacgacgt atctggccta taacgagccg attgagatcc agtacggagg ggttgtgtac 1661941 gatcccggag atgacagaag aaaaacgcat cgtcataccc tgaaaggaaa gacaagggaa 1662001 attgtcggca atgagccgct cggctggtag aaggatgttt accgatgcaa aaaaagggca 1662061 aaatggatag gtggttgtcc atgttgaatg ctataatggg gggagattta taaaagagag 1662121 tgatacatat tgaataatac gaagcagccc gttgtcattt tagtcggacc gacggcagtg 1662181 gggaaaacca atttaagtat tcagctagcc aaatccttaa acgcggaaat tatcagcgga 1662241 gattcgatgc agatttataa agggatggat attggaacag ctaaaattac cgaacaggag 1662301 atggagggag tgccccatca tctgattgac attttagatc cccaagactc tttctctact 1662361 gccgattatc aaagcttagt aagaaataaa atcagcgaga ttgcaaatag aggaaagctt 1662421 ccgatgattg tcggcggtac agggctttat atacaatctg tgctttacga ttatacattt 1662481 acggaagagg caaatgatcc cgtgtttcga gagagcatgc aaatggctgc tgagcgggaa 1662541 ggcgctgact ttcttcatgc caaacttgct gcagcagatc ccgaggcagc agctgcgatt 1662601 catccgaata atacaagaag agtcattcgc gcactggaaa ttttacatac gtccggaaaa 1662661 acgatgtccc agcatttgaa ggaacaaaaa cgagaacttc tgtacaatgc agtgttaatt 1662721 ggcctgacaa tggatagaga cacgctttac gaaagaatta atcagcgggt cgatttgatg 1662781 atgcagtcag gccttcttcc ggaagtgaaa cgcttatacg acaagaacgt gagagactgt 1662841 caatcaatac aggcgatagg ctataaagag ctgtatgcat attttgacgg ttttgtgaca 1662901 ctttccgatg ctgtcgaaca gctaaagcag aactcgaggc ggtatgcgaa acgccagctg 1662961 acgtggtttc gcaacaaaat gcaggtcaca tggttcgata tgacaccgcc tgttgatatg 1663021 gagctgaaaa aaaaggaaat tttcacacat atagcaggaa aactcgaact ttaatcgaaa 1663081 ctgtatgata tagagaatca aggaggacga aacatgaaac cgattaatat tcaggatcag 1663141 tttttgaatc aaatccggaa agaaaatacg tatgtcactg tttttttgct gaacggcttt 1663201 cagttgcggg gccaggtgaa aggctttgat aactttaccg tattgttgga atcggaaggt 1663261 aagcagcagc ttatatataa acatgcgatc tcaacgtttg cgccgcaaaa aaacgtccag 1663321 cttgaactcg aatagatcaa aaaatgccat gtcaagacat gaggaaaggc tgtcgggggt 1663381 tcccggcggc catttttaac atgaatccac ttttgctcca agctttttgt gtaagctgac 1663441 catgccaagg cacggtcttt ttttatgaga acaacatacg gaagtaaaaa tggtatatta 1663501 tgtataaaat gaatttggga gtgatcgatc ttgtttgaaa gtgaagcaga actgagacga 1663561 atcaggattg cacttgtatg gatagctgtc tttttactgt tcggggcgtg cgggaatcaa 1663621 gataccatta ttgaaacaga caacggcaat tcagactatg aaacgcctca gcccacctcg 1663681 tttccacttg aacataacca ttttggcgtt atggaggacg gctatatcaa aatttatgag 1663741 tataatgagt cccgcaatga ggtaaagctg aagaaagaat acgcggatga tgagcttgaa 1663801 taaaattcac aagcattcga atttacaaag cggatgccag ccgctaaact aaatacagac 1663861 acagatcaaa cagagggtga aaacatgaag cataaagtga tcgtgaatca ttgggaagaa 1663921 atttgcgaag atgattcttg ctatgaatac ggaacaagta tcattgtgaa cggaaaagaa 1663981 ttaatcagag aagcgtcaat tatcactgct ttgaaggcgg ttttagaaga gatcggcgcg 1664041 gatgttgaaa tagaagaaac agtagagagc gaaaaatgct gtgatagctt aagaaaaaaa 1664101 aatctagact actaagcagt tttttttcat gttatgatat acatcggcta aaaacgacac 1664161 cccgagtagg acgagagatg attctcgttc tgctctcttt tttgggccct aatgagtctg 1664221 cccgtttgcc tgatttgatc aaaatatgaa tttttcataa aaacgaatct atatattgtg 1664281 tttttgctag agggtagtat actatatata gtgttagtga tgagagattc atattttttg 1664341 ataggtcgtg ataaaacgtg gtacaaatca tatttgattc gaaaacaggg aatgttcagc 1664401 ggtttgtgaa taaaacaggc tttcagcaga tacgcaaggt ggacgaaatg gaccacgtgg 1664461 acactccgtt tgttttggtc acctacacga caaacttcgg ccaggtaccg gcatcaacac 1664521 aatcatttct cgaaaaatac gcccatctct tattgggagt cgctgcgagc ggcaacaaag 1664581 tatggggcga taactttgca aaaagcgccg ataccatttc aagacaatat caggtgccga 1664641 tcttgcacaa atttgaactc agcggcacat ctaaagacgt tgaattgttt actcaggagg 1664701 tagaaagagt tgtcacaaaa tcaagtgcca aaatggatcc agttaaataa cgaaatcatg 1664761 atccaaaaag atgggaaatt ccagtttgat aaggataaag aagctgtaca tagctatttt 1664821 gtagattata tcaatcaaaa cacagtcttc tttcacaatt taaaagagaa gctggattat 1664881 ttggttgaaa accaatacta cgaagaggaa ttcttaagcc tttattcttt tgaagacatt 1664941 aaagaagtgt ttaagacagc ttacgctaag aagtttcgtt ttccttcctt catgagtgcg 1665001 tttaaattct ataatgacta tgctttgaaa acgaatgaca agaaaaaaat cctcgagcgt 1665061 tatgaggacc ggatctcaat tgttgcgctg ttcttcgcta acggcgacac tgagaaagca 1665121 aaagaatatg taaacctgat gatcaatcaa gaatatcagc cgagcacacc gacatttttg 1665181 aatgccggca gaaaacgccg cggtgaactt gtgagctgct tcttgctcga agttaatgat 1665241 tctttaaatg acatttcaag agcaatcgat atctccatgc agctttctaa gcttggtggc 1665301 ggggtttctc ttaacctgtc caagcttcgc gcgaaaggtg aagccattaa agatgttgag 1665361 aatgcgacaa aaggcgttgt aggcgtcatg aagcttcttg ataacgcgtt ccgttacgct 1665421 gaccaaatgg gacaaagaca aggctccggc gcggcgtatt taaacatttt ccaccgcgat 1665481 atcaatgatt ttcttgatac gaaaaagatt tctgcggatg aagatgtgcg tgtcaaaacg 1665541 ctttcgatcg gtgttgtcat tccggataag ttcgttgagc ttgcacgcga ggacaaagcg 1665601 gcttatgtat tctacccgca cacgatttat aaagagtacg gccagcacat ggatgagatg 1665661 gacatgaacg aaatgtacga caagtttgtc gacaaccctc gggtgaaaaa ggaaaaaatc 1665721 aacccgcgga aactgcttga aaaattggcg atgcttcgtt ctgaatcagg ctatccatac 1665781 atcatgttcc aagataacgt caataaagtg catgcgaata accatatttc caaggtcaaa 1665841 ttttctaacc tttgctctga agtgctgcag gcatctcaag tttcttcata cacagactat 1665901 gatgaagaag atgaaatcgg tctggatatt tcctgcaacc tgggttcgct taacattctc 1665961 aatgtcatgg agcataaatc aatcgaaaag acagtcaagc ttgcgacaga ctctttaaca 1666021 cacgtgtctg aaacaacaga catccgtaat gcgcctgctg taagacgggc aaacaaagcg 1666081 atgaaatcaa tcggcctcgg tgctatgaac cttcacggct accttgcgca aaacggcatt 1666141 gcgtatgaaa gtccggaagc gcgtgacttt gcaaacacgt tctttatgat ggtgaatttc 1666201 tactccatcc agcgttctgc ggaaatcgca aaagagaagg gcgaaacgtt tgatcaatat 1666261 gaaggatcaa cctatgcgac aggtgaatac ttcgacaaat acgtttcaac tgatttctca 1666321 ccgaaatacg aaaaaatcgc taatctgttt gaaggtatgc atatcccgac gacagaggac 1666381 tggaaaaagc taaaagcatt tgtcgctgaa cacggtatgt atcacagcta cagattatgc 1666441 attgcgccga caggctctat ctcatacgtt caatcaagca cggcgtctgt tatgccgatt 1666501 atggaacgga ttgaagaacg aacatacggc aactcaaaaa cgtactaccc aatgcctggg 1666561 cttgcatcta ataactggtt cttctataaa gaagcctacg atatggacat gttcaaggtt 1666621 gtggatatga tcgccactat ccagcagcac attgatcagg gaatcagctt tacattgttc 1666681 ttaaaagaca caatgacgac ccgagattta aaccgaatcg atctgtatgc acatcataga 1666741 ggaattaaaa ccatttacta tgcaagaacg aaagatactg ggcaagacag ctgcctttct 1666801 tgtgttgttt gattaaagga gagtttatag tgacaaaaat ttatgacgca gcaaactggt 1666861 caaagcatga agacgatttt acccaaatgt tctataacca aaacgtgaaa cagttctggc 1666921 ttccggaaga gattgcttta aacggcgatc tcctcacatg gaagtacctc ggaaaaaatg 1666981 agcaggacac ttatatgaag gtactggccg gacttacgct tcttgacaca gagcagggga 1667041 atacggggat gccgatcgtg gctgaacacg tagatggcca ccagcggaaa gcggtgctga 1667101 actttatggc gatgatggag aacgctgtcc atgcgaagtc gtactctaat attttcatga 1667161 cccttgcacc gactgaaacg atcaatgaag tatttgaatg ggttaaacaa aataaatatt 1667221 tgcagaaaaa agcgcaaatg attgtcgggc tttacaaagc cattcaaaaa gatgatgaaa 1667281 tttcactgtt caaagccatg gttgcttccg tctatctgga aagcttcctt ttctacagcg 1667341 gtttctatta tccgttatat ttctacggac aaggaaaact gatgcaaagc ggtgagatca 1667401 ttaacctgat ccttcgtgac gaagcgattc acggcgtgta tgtcggtctc cttgctcagg 1667461 aaatttataa taaacagaca gaagagaaaa aagcagagct tcgtgaattt gcgatcgacc 1667521 tcctgaatca gttatatgaa aatgagcttg agtatacaga ggacttgtac gatcaagtcg 1667581 ggctctcaca tgatgtaaag aaattcatcc gctataatgc gaataaagcg ctgatgaacc 1667641 ttggatttga tccatacttc gaagaggaag acattaatcc gatcgtttta aacggattaa 1667701 acacaaaaac aaaatcgcat gacttcttct ctatgaaggg gaatggctat aaaaaagcga 1667761 cagttgagcc gctcaaagat gatgactttt attttgaaga tgaaaaagag cagatataat 1667821 atctgctctt ttcggcttga aggttcaaat gaggaggacg cagtacccat gggaaaaatg 1667881 gacgaaatga ttttagttgc cccgcgcgat gatgtgttta aaaaagaaag cttaaccttc 1667941 cagggcgtgt acagtgaaga tagcagagta gcagaaatca tggctcagat tgaagcggcc 1668001 tatcgtgaaa tgagaagagg ggacgcagaa gaagatccgc gtttcaagca gccgatacct 1668061 tatgtcgtca ttaagcgtga agatgaagtt tttctttacg agcggctggc tggcggcggt 1668121 gaatcacgtc tgcacaacaa gctttctctc ggttttggcg gccatatgaa cgccatcgaa 1668181 ggggcagctt catttgctga agtcttaaag ctgaacacag accgtgagct tgaggaagaa 1668241 ctgcaaataa atgaagaaga taaacaggcg attgtcacac tgggattgat caatgatgat 1668301 gaaaacagtg ttggcaaagt gcatatcggt attctttctg cgcttcaatt aaagcctggc 1668361 gcacaagtgg aagtgaagga gaaagaacaa attgcgggta aatggatgaa agtttctgaa 1668421 ttaaaacagg atgatatcta caaccgtctg gaaacatggt cacagtttgt tgttgatatt 1668481 cttgaataaa aaaacccggt ttctcgcgat gaggagccgg gtttttttat gagacgctcg 1668541 tccccgtctc ggctatgatt ctaggatcac aatagcgtca aagccggcat ttttcgctct 1668601 ggcagcgagg gtgtctgcat tgtctttgga tgaaaatgcg ccaatctgca ctttgtataa 1668661 tccgtccttt aaaaggacaa tcgagtcaaa acctttggct tcggcattac ttgcgagcga 1668721 gtcggcattc gctttgactt taaatgcgcc gatttgaacc ttatataacc ctgagctgga 1668781 agtcttttta aggttaaagg cttgctccag cccgtttgca tgtcctctcg ctaagctttg 1668841 aataaaactg ctcgttttca gcttatttgc atcggaaacg gtatcaatga agccgttctc 1668901 ggtcaagagg gcaggcattg ccgactccct taggacgtgg aagttcgctg tttttttgcc 1668961 gcgatcggca aagtcgacag cttgtatcac ttcagagtga attgtcgatt gataagtcgt 1669021 cgtcggggct cctacatctg gataaatata gctttcaaaa cctgtgcctc ccccggaatt 1669081 aacgtgaatg gacaaaaaga aatctgctcc ccagttattt gcggcatttg tccggtcgtt 1669141 taagctgaca tattggtcgc ttgtccggct cagcagcaga gaaacgcctt catattcatt 1669201 agttaatatc gtacgtaagg ctaaagcgat ttgcagggtt aacgttttct cctgaaggcc 1669261 attacctgtt gcgcctggat cagacccgcc atggccagga tcaataaaaa ttttaaccat 1669321 ttttcatcac ctcattacag gatatgaaaa aacacggctt ctgcttgtac gattatcatt 1669381 caactgaaaa atgaggaaat aaccctttca catccagaaa ttatttctcg ggaaagcgca 1669441 caattcaaca tgaagcgaca acagatacgg tccgacatga aatctgtgca tacgccatat 1669501 gtttgtatgt actatgggtt cggttaacct gcactgattc ctgctggttt taagctttgc 1669561 gttcatatta aatcaagcat ttaaaacgta aattgatgag gaaagctcct ttcattaaag 1669621 acaccgcttt ataaatcgaa aaaaagaaaa acacttcagg tatcttaggg cgggtaatac 1669681 gtttcgtaca aaaatcagcc cgttgtatga aaaagaaata atgagaaaga agctcactat 1669741 aatactctga caaaatgatt aaaaacaaaa tctcatggtt tgtccacccc atgtccgtga 1669801 atacaataag aaataaagta tttctcggga aagcgcagga ttccttattg ttcccgaaaa 1669861 aagcaattgt ttcgacacat gataggcgtt tgtcacaatc ggcatccgct tgaatatcat 1669921 atagagagaa cagagaggtg aagatgttgg agcgcgctgt gacttataaa aacaacggac 1669981 agatcaacat tattctgaac gggcaaaagc aggtgctgac gaatgctgag gcagaggcgg 1670041 aatatcaggc tgcattgcaa aaaaacgaag caaagcacgg cattttgaag gaaatcgaaa 1670101 aagagatgag cgcattagtt gggatggagg aaatgaaacg caacatcaag gaaatatacg 1670161 cctggatttt tgtgaaccaa aaacgcgcgg agcaaggctt gaaggttgga aagcaagcgc 1670221 tgcacatgat gtttaaagga aatccgggaa cgggaaaaac gacggttgca cggctcatcg 1670281 gcaagctgtt ctttgaaatg aatgtcctgt caaaaggcca cttaatagaa gcggagcggg 1670341 ctgacctggt cggggagtat atcggacaca ccgcccaaaa gacgagagat ttaatcaaaa 1670401 agtcattagg tggcattttg tttatagacg aagcctactc gctggcaaga ggcggcgaaa 1670461 aggactttgg gaaagaagcg atcgacacac ttgtaaagca tatggaagac aaacagcatg 1670521 agtttatttt gatactcgcc ggatattcac gggaaatgga tcattttctc tcgttaaatc 1670581 ccggactcca atcaagattt cccatctcca ttgattttcc ggattactct gtgacccagc 1670641 tcatggagat tgcgaaacga atgatcgatg aaagggaata ccagctcagt caagaagcgg 1670701 aatggaaatt gaaagattac ttaatgacag tgaaaagcac gacaagtccc attaaattca 1670761 gcaatggacg ttttgtcaga aatgtgatcg aaaaatcgat cagagcacaa gccatgaggc 1670821 ttttaatggg agaccaatac ttaaaaagcg acttgatgac catcaaaagc caagatcttt 1670881 ccattaaaga agaagcatct ggatctgcat agacctctca gtttttgaga ggtctgtttt 1670941 ttgctcgtat ttccgctttt caaagcaatc gatttgtggt atacacatgc agggtttggt 1671001 atgataatac tactgcccaa tatgcaaaag aaaggaacat ccatttgaac gaacaagaaa 1671061 cgattcagga gaaagccatt ttagtcggat gtcagctgcc gcatatcacg gatgagcatt 1671121 ttgaaaattc tatggaagag ctagcatctc tgacgaaaac agcagacgga aaagtactga 1671181 ccagcgtcac acaaaaacgg aacagggctg acgccgctac atatatagga aaagggaagg 1671241 tagaagagct gaaggcactc gtggaagagc ttgaagctga tctcctcatc tttaatgatg 1671301 aactgtcgcc aagtcagctg aagtcattgg caacagcaat tgaagtgaag atgattgacc 1671361 gcacgcaatt gatattagat atttttgcaa agcgggcgag aacgagagaa ggcaaacttc 1671421 aaattgagct ggctcagctg caatatgcac tgccgcgtct gacgggacaa gggatcaacc 1671481 tttcccggca aggcggagga attggggcaa gaggtcccgg ggaaacgaaa ctggaaaccg 1671541 accgccgcca tatcagaaat cgcattcatg aaatcaacac acagctttcc actgtcattc 1671601 gccatagaag ccgataccgt gaaagaagaa agaaaaacgg tgtgcttcaa attgcgcttg 1671661 tcggctatac aaacgcaggg aaatcaacat ggttcaaccg cctgacgagt gctgacagct 1671721 atgaagaaga cctcctgttt gccacgctgg acccgatgac cagaaaaatg gtcctgccaa 1671781 gcggctacag tgttcttctt tcagatacag taggatttat tcaggatctt ccgacgacat 1671841 tgattgctgc attccgctca acgcttgagg aagtaaaaga agcggattta attctgcatt 1671901 taattgattc ttcaaatgag gattatgcgg gacatgaaaa aacagtgctt cggctgcttg 1671961 aggagcttga agcagatgat atcccgatgc tgacggctta caataaacgt gatcaaaaac 1672021 tgcctgattt tataccgacc gccggaaggg atcacattat ggtcagtgcg aaatttgagg 1672081 acgacgctgc agcctttaaa gaagcgattc agcgctattt gcgccaagaa ctgttaacgt 1672141 cttttgaagc acatgtgccg gcaagtgaag ggaagctcct ttccagaatc aaatcggaaa 1672201 cgatggtaga ccgcttctat tttaatgaag aaaatgaaca gtatgacata tccggctatg 1672261 tccaagaaga gcaaagtatc atcggtgaat taaagaagta tatgtaggaa ggaaatataa 1672321 agacatgttt gacacattaa cacacggaga attattgaag aaaacggcaa tggaagtgga 1672381 agcggacatt gccggcattc ataaacaaat agaagaaatc agcgagcgaa atgagtggag 1672441 agtgcttcaa agctatagaa aacacaaagt aagcgacact catttcacgc cgtctactgg 1672501 atacggctat gatgatatcg gaagagacac gcttgaaagc atatatgcgg atgtgtttgg 1672561 cggagaagcg gggcttgtaa ggccgcaaat catttcaggc acacatgcca tctcaattgc 1672621 tttgttcggt gtcctcagac cgggggacga gctcctttat atcacgggca agccgtatga 1672681 tacgctagag gaaattgtgg gcgtcagggg tggagaaaac gctggttcgt taaaggattt 1672741 tcaaatcggc tataatgcgg ttgatctgac gaaagacgga aagatagact atgatgcagt 1672801 cgccgctgcg atcaatccga agacaaaagt aatcggcatt cagcgctcaa aaggatatgc 1672861 gaatcgccct tctttcttaa ttagtgaaat aaaagaaatg atccgttttg taaaagaaat 1672921 caatgaaaat ctgatcgtct ttgtggacaa ctgttacgga gaatttgtgg aagagcttga 1672981 gccttgccat gtcggagccg acctgatggc gggatctctc attaaaaatc ccggcggcgg 1673041 ccttgcgaaa acaggcggct acctcgtcgg aaaagcgaaa tggattgaag cttgctcata 1673101 ccgtatgacg tcacccggca tcggcagaga agcgggggca tctctttact cgctccaaga 1673161 aatgtaccaa ggcttctttt tggcgcctca cgttgtgtct caaagtttaa agggagcggt 1673221 gtttacagcg agattccttg aaaaactcgg cttcacttca aacccgaaat gggatgcgaa 1673281 aagaacggat ttaatacaat ccgttgagtt ttctgacaga gaaaagatga ttgctttttg 1673341 ccaggctatt caatttgcat cgccaatcaa tgctcatgtg acgccttatc cagcctacat 1673401 gcctggatac gaggatgatg tcattatggc agcagggacg tttattcaag gagcaagcat 1673461 cgaattatca gctgatggcc ctatccgccc gccgtatgta gcgtatgttc agggaggatt 1673521 aacctattcg catgtgaaga atgccatatg cagtgcagtg gattcattga tgcaaaagca 1673581 attaatttaa attttttaaa aatttctctg gatttgatgt taagaatcct tacatcgtat 1673641 tgacacataa tataacatca cctataatga aactaagtta agaaaaggag gaaattgaga 1673701 tgagtgataa tattcgccgc tcaatgcctt tatttccaat aggaattgtc atgcagttaa 1673761 ctgagttatc agcaagacaa attcgatatt atgaggaaaa tggactgata tttccagcca 1673821 gaagtgaagg aaatagacga ttattttcat ttcatgatgt agataaactg ttagaaatca 1673881 agcacctgat agaacaaggt gtaaacatgg caggaattaa acagattctg gcgaaagccg 1673941 aagccgagcc agaacaaaaa caaaacgaga agacgaaaaa accaatgaaa catgatctgt 1674001 ccgatgacga actgagacag ctcctgaaaa acgagctcat gcaagccggc cgttttcaaa 1674061 gagggaatac attccgtcaa ggcgacatgt cccgcttctt tcattaatcc gttagcaact 1674121 gttttgctat atacatttac cttttaagag gaggaatttt accaaatggc aaagtacact 1674181 agagaagata tcgaaaaatt agtaaaagaa gaaaacgtga agtatatccg ccttcaattt 1674241 actgacattc ttggaacaat caagaatgtt gagattcctg taagccagct tggaaaagcg 1674301 cttgataata aagtcatgtt tgacggttct tctattgagg gattcgttcg tatcgaagag 1674361 tcagacatgt acctgtatcc agatctaaat acatttgtta tcttcccatg gacagctgaa 1674421 aaaggtaaag tagcacgttt catctgtgat atttacaatc cggatggcac accttttgaa 1674481 ggtgacccgc gaaacaactt aaaacggatt ctgaaagaaa tggaagacct cggcttcagt 1674541 gattttaacc ttgggcctga gcctgaattc ttcttattca aattggacga aaaaggcgag 1674601 ccgacgcttg aactaaacga caaaggcgga tatttcgact tagctccaac tgatttagga 1674661 gaaaactgcc gccgcgatat cgtacttgag cttgaagaga tgggctttga aatcgaagcg 1674721 tctcaccacg aagtagcacc tggtcagcac gaaatcgact ttaaatatgc tggagcagtc 1674781 cgctcttgtg atgacatcca aacatttaaa ctagttgtca aaacaattgc ccgtaaacac 1674841 ggcctgcatg cgacatttat gccaaaacca ttgttcggtg taaacggttc aggtatgcac 1674901 tgcaatctat cactcttcaa aaatggtgtt aacgcattct ttgacgaaaa cgcagatctt 1674961 cagttaagtg aaacagcgaa gcacttcatt gcaggtatcg tgaagcacgc aacaagcttt 1675021 acagcagtaa caaacccgac agtaaactct tacaaacgtc ttgttcctgg ctatgaagca 1675081 ccttgttatg tagcatggag cgcgcaaaac agaagcccgc ttatccgtat cccggcttct 1675141 cgcggcatca gcacacgtgt tgaagtacgc agtgtagacc cagctgcaaa cccatacctt 1675201 gcacttagcg tattgcttgc tgcaggatta gacggaatca aaaacaaact ggaagcgccg 1675261 gctccaatcg accgcaacat ctatgtgatg agcaaagaag agcgcatgga aaacggaatc 1675321 gttgaccttc cagcaacact tgcggaagca ctagaagaat tcaaatcaaa cgaagtcatg 1675381 gtcaaagcgc tgggcgagca cctattcgaa cacttcatcg aagcaaaaga aatcgaatgg 1675441 gatatgttcc gcacgcaagt acatccttgg gaacgcgaac agtatatgtc tcagtattaa 1675501 tatctcaatc ccttggcact aaaagtgtca ggggattttt tatgttaata ggtaataaat 1675561 tatggagcgg catagtgttt aacacagcca ttaatcctca gacagtcaaa tagccatttc 1675621 tactccggtt gaaagcttct ctatttttgc ttcttattta tctttcctgt attgatatat 1675681 gtatgtaggg ttggacttat aacataaact attctggcca ttccgttctt tcaattcatg 1675741 accgggcttg ccatcagcat aaatctaggc taacagtctc catacatcct gtgatcacct 1675801 ttatcaaact cttaaatgca acttaccact aaccaattct ttatttcgca tagatcatct 1675861 ttgtcatgtg tttacacaag aatctgtttt ggactgagac actgaatata acaaaacagt 1675921 caaaaatcaa tatttaattc attctgttta aactttctga aaaagatgtt gaaaaagtcg 1675981 aaaggatttt ataatattaa gtcaagttag tttgtttgat caacaaacta atgaaatgaa 1676041 ctttcattat ccacaagata agatcttact aatatggatg gaagggggat aagagggtcg 1676101 atttaatgga gctaaacaat ataagaaacg aaagaatgag gcttttatcc ttttccaggt 1676161 atataaggta tgacgaaaaa agatgaattt tttgcttgct gatcaccata tttttttgca 1676221 ctgttttgaa agcgctttta taaaagttta ctgaccgtaa attcgagaaa ttgttatacc 1676281 gtttcacact gttccatatt aaaggatcga aaaggggaga aatcatgctc agtgaaaatg 1676341 taaagaagat tagcatggtt gaaaaagttg gatatgcgtc tggagatttt gcttgtaatt 1676401 taatttatgc aacagtgtct acgtatcttt tgttcttcta tacagatgtt tttggtttat 1676461 cggcagcagc agccggtact atgtttttag tggttagaat aatcgacgct ctcgctgatc 1676521 cttttatcgg aacaatagtt gacagaacga acagcagatt tggacgcttt agaccgtatc 1676581 ttttattcgg agcttttcca tttgtcatac tggcaatact ctgttttaca acaccagact 1676641 tttcggatat ggggaaatta atatatgcct atataaccta tgttggcttg tcgcttacat 1676701 acacaacgat aaacgttcca tatggcgcgt taacttctgc aatgactaga aataatcaag 1676761 aagttgttag tataacttct gttcgcatgt tatttgcgaa tcttggggga cttgtcgttg 1676821 cattttttgt tcccttactg gctgcttatt taagcgatac ttccggcaac gagtctcttg 1676881 gctggcaact aaccatgggt attttgggaa tgataggcgg gtgcctttta atcttttgtt 1676941 ttaaaagcac aaaagagcgg gtcactcttc aaaaatccga agagaaaatt aaatttacgg 1677001 atatatttga gcagtttcgt gttaatcgtc cacttgttgt attaagtatt ttctttatta 1677061 ttatttttgg agtgaattcc atcagtaatt cggttggcat ttactacgta acgtataact 1677121 tagaaagaga ggatttggtg aagtggtacg gtttgatagg aagtttaccc gctttggtca 1677181 ttttaccgtt tattccaagg cttcatcaat ttttggggaa aaagaaatta ctaaactatg 1677241 cattattact gaatattata ggcctcttag ctttactgtt tgttccgcca agtaatgttt 1677301 acctcatact tgtctgtcga ttaatcgctg ctgctggaag tctcactgcc gggggatata 1677361 tgtgggcgct tattcctgaa acaattgaat atggagagta caggactggg aaaagaatgg 1677421 gtgggctcat ttacgctata atcggatttt tctttaagtt tggtatggcc ttaggaggag 1677481 ttgttccggg tctggttctt gataagtttg gatatgtagc aaatcaggca caaaccccgg 1677541 cggccttaat ggggatttta attacaacaa ccattattcc cgtgttcttg cttgttctag 1677601 ctttaattga tattaatttc tataacttag atgagaaaaa atataaaaac atggttcgag 1677661 aattagagaa tagagacaaa gtttatttgg atcatattga tgatttcaag gcttaaaaaa 1677721 gaaaataaac tgaggaggag tcccaaatga agattaccaa tcccgtactt aaaggattca 1677781 atcccgatcc aagtatttgt agagcaggag aggattatta tatcgctgta tctacatttg 1677841 agtggtttcc gggagtccag atacaccact caaaagattt agtaaattgg cacttagttg 1677901 cacatccatt acagagagtt tcacaattag acatgaaagg aaacccaaat tcaggtggag 1677961 tttgggcacc atgtttaagc tatagtgatg ggaagttttg gctgatctat acggatgtta 1678021 aggtagtaga tggcgcatgg aaagattgtc acaattattt agttacttgt gaaacgatta 1678081 atggtgattg gagtgagccg attaaattaa atagctcggg gtttgatgct tctttgttcc 1678141 atgatacgga tggaaaaaag tatttattaa atatgttatg ggatcaccgt attgatcggc 1678201 actcatttgg aggaattgtt atacaggaat attctgataa agagcaaaaa ttaatcggta 1678261 aaccaaaagt tatatttgaa ggaactgata gaaaactgac agaagctccg catctttatc 1678321 atatcgggaa ctattattat ttattaactg cagaaggagg aacacggtac gaacatgctg 1678381 ctacaattgc tcgttctgca aatattgagg ggccatatga agttcatccc gataatccaa 1678441 ttttaacgtc atggcatgac ccaggaaatc cattgcaaaa atgtggtcat gcatccattg 1678501 ttcaaacaca tacagatgag tggtatttag ctcatttaac gggacgtcct attcatcctg 1678561 acgatgattc aatttttcag cagagaggat actgtccttt gggcagagaa acagctattc 1678621 aaaaacttta ctggaaagat gaatggccct atgtagtagg tggaaaagaa ggaagcttgg 1678681 aggtagatgc accttctata cccgaaacaa tatttgaagc aacgtacccg gaagttgatg 1678741 aatttgagga ttcaacatta aatataaatt ttcaaacttt aaggattcca ttcacgaatg 1678801 aattaggttc attgactcaa gcgccaaatc atttacgatt attcggtcat gaatcattga 1678861 cctcgacatt tactcaggca tttgtagcca gacgctggca aagtctccat tttgaagccg 1678921 aaactgctgt tgagttttat ccggaaaatt ttcaacaagc cgctgggttg gtgaattact 1678981 acaatacaga gaactggacg gctcttcaag tcacgcatga tgaagaactt gggcgcattc 1679041 ttgaattaac aatatgtgac aacttttctt tttcacagcc attaaataat aaaattgtta 1679101 ttcctcgtga agtaaagtat gtatatttaa gagtaaatat tgaaaaggac aaatattatt 1679161 atttctattc ttttaacaaa gaagattggc acaaaattga cattgcactg gaatcgaaaa 1679221 aattatcaga tgattatatc cgtgggggag gattcttcac aggggccttt gtagggatgc 1679281 aatgccaaga taccagtggt aatcatattc cggccgactt tagatatttt cgttataaag 1679341 aaaaataatt tgcacatgaa aaaggagatt tctattttag aactcctttt tcatatgaga 1679401 aggtgccatg tcactattgc ttcagaaata ctcctagaat aaaaaaactc atctttaaag 1679461 atgagctgtc cattccataa aaaattacat tgtaatcatg tccagaaaat gatcaatcac 1679521 aatggaggac attcctaatg ccggtgcatt ctgtcctaag gaagatggca ataattcata 1679581 gctattgcct aattgggaat aaacccttga tgatacttca cttctcattg aatttaaaac 1679641 cataggatgc gattcaatta tgctatttct taaaattacg gcttgtgggt tgaaagtatt 1679701 tagaatattg gtaaggccta ttcctaaata gaatccaaaa ttttgtaatg catttaaggt 1679761 tccgatatca ttcagatggg cgaggtttat gatatcttga taggacagtt ttttctcttt 1679821 ggtctgaaga gattttaata aagccttctc tgaagcatac aattcccagc atcctcggtt 1679881 tccgcaactg catttaggac cattaaagtc tattgtcata tgtcccattt ctccagagaa 1679941 gccgcttact cctctatata aatgattgtt gataataaca ccgatcccta ttcctgtgct 1680001 gatacttacg taaataatgt tatcgtgatt ttttgcagct ccaaatactt tttctccata 1680061 tgcgccagca tttgcctcat tttcaataaa aacaggcaca ttgtacttct cttgtatcga 1680121 agattttaag tcaatatctc tccagttgga gttcggagtg aaaacaattt tttgatcttt 1680181 atcaatgagt ccaggcacgc aaatacctat accaataagc ccgtacggag attggggcat 1680241 ttgcgtaata aagtgatgaa tcatatcaat caaaatgtct ttcgttattt ctggagaatt 1680301 ggattccaaa tggcggtatt gatcaagaac gattgttcct tcaaggtctg ttaaaatgcc 1680361 attaatataa tccacaccaa catctattcc aacggagtat cctgcctttt tattaaaaac 1680421 aagcatgaca ggtcttcttc cgccacttga ttgtccttga cctatttcaa ataccatact 1680481 ttctttcatt aacgtgttta cctgtgatga gacagttgat ttatttaatc cagtcatttc 1680541 agataatttt gctcttgaaa taggtgaatt tttaaggatt tcttttaata ataacttttg 1680601 atttactttt ttgacaaagg tttgatcagc gatatccact tcatccactc catttgttta 1680661 atctttaaat taagtatcaa catagtacat agcgaatctt ccctttatta tatctaatgt 1680721 gttcataaaa aactaaaaaa aatattgaaa atactgacga ggttatataa gatgaaaata 1680781 agttagtttg tttaaacaac aaactaatag gtgatgtact tactatatga aataaaatgc 1680841 atctgtattt gaatgaattt atttttaagg gggaaatcac atggctcaat ctcattccag 1680901 ttcaatcaac tattttggaa gcgcaaacaa agtggtttac gaagggaaag attcgactaa 1680961 tcctttagca tttaaatatt ataatcctca agaagtaatc ggcggaaaaa cgctgaaaga 1681021 gcatttgcga ttttctattg cctattggca tacatttact gctgatggta cagacgtttt 1681081 tggagcagct acgatgcaaa gaccatggga tcactataaa ggcatggatc tagcgaagat 1681141 gagagtagaa gcagcatttg agatgtttga aaaactagat gcaccattct ttgcttttca 1681201 tgaccgggat attgcaccag aaggcagtac gctaaaagag acaaaccaaa atttagatat 1681261 gatcatgggc atgattaaag attacatgag aaatagcggc gttaagctat tatggaatac 1681321 agcaaacatg tttacgaatc cccgtttcgt ccatggtgcc gcgacttctt gcaatgcaga 1681381 tgtgtttgcg tatgctgcag cacaagtgaa aaaagggtta gaaacagcaa aagagcttgg 1681441 cgctgagaac tatgtatttt ggggcggccg tgaaggatat gaaacattgt taaataccga 1681501 tttaaaattt gagcttgata atttggctag atttatgcat atggcagtgg attatgcgaa 1681561 ggaaatcggg tacacagggc agtttttgat tgagccaaaa ccaaaagagc cgaccaccca 1681621 tcaatacgat acagatgcag caacaaccat tgcctttttg aagcaatatg gcttagacaa 1681681 tcattttaaa ttaaatcttg aagccaatca tgccacatta gccgggcata cattcgaaca 1681741 tgaattacgc atggcaagag tacatggtct gcttggctct gttgacgcaa accagggtca 1681801 tcctctttta ggctgggaca cggatgaatt tccgacggat ttatattcta cgacattagc 1681861 aatgtacgaa atcctgcaaa atggcggcct tggaagcggc ggattaaact ttgacgcgaa 1681921 ggtcagaaga tcttctttcg agcctgatga tctaatatat gcccatattg cagggatgga 1681981 tgcatttgca agaggattga aagttgccca caaattaatc gaagatcgtg tgtttgaaga 1682041 tgtgattcaa catcgttacc gcagctttac tgaagggatt ggtcttgaaa ttatagaagg 1682101 aagagctaat ttccacacac ttgagcaata tgcgctaaat cataaatcaa ttaaaaacga 1682161 atctggaaga caggagaaat taaaagcgat attgaaccaa tacattttag aagtataaca 1682221 ggataagctc cagatcctgc tatcaatacc aagtcactga attacccgtc atgattcctt 1682281 tcctattgct tgttgttatg acgggtaact tctataatta ggatttattt agagtgaatg 1682341 gttttttaaa agggcaagga gtgaaaaaat gaagtatgtc attggaatag atcttggaac 1682401 gagtgctgtt aaaaccattt tagttaacca aaacggcaag gtttgtgcag aaacgtccaa 1682461 aaggtatccg ctcatccaag agaaggcggg atatagtgag caaaatcctg aagactgggt 1682521 tcagcaaaca attgaagcat tggctgaatt ggtttctata tccaatgttc aagccaagga 1682581 tattgacggg ataagctatt cgggacaaat gcatggatta gtactgcttg accaagatcg 1682641 tcaggtgtta cgtaatgcaa ttctttggaa tgataccaga acaacgcctc aatgtataag 1682701 gatgaccgag aaatttggcg atcatcttct tgacatcaca aaaaaccgtg ttttagaagg 1682761 gtttacatta cctaaaatgt tatgggtaaa ggaacatgaa cctgaacttt ttaaaaaaac 1682821 tgctgtgttt ttgcttccga aagactacgt gcgattccgt atgaccggtg tcattcacac 1682881 cgaatactcc gatgcagcag gaactttact tttacatatt actcgcaagg agtggagcaa 1682941 tgatatttgc aatcaaattg gtatttctgc agatatttgt cctccgcttg ttgaatctca 1683001 tgattgtgta ggatcgctgc ttccgcacgt tgccgcgaag accgggctat tagaaaaaac 1683061 aaaagtgtac gctgggggag cagataatgc ttgcggcgct attggagcag gtatcctttc 1683121 ttccggaaaa acattatgca gtattgggac gtcaggggtc atactttcct acgaagaaga 1683181 aaaagaaaga gactttaaag ggaaagtcca cttttttaat catggaaaaa aggattcttt 1683241 ttatacgatg ggcgtcacgc tcgctgcagg atacagcttg gactggttta aaagaacgtt 1683301 tgcaccaaac gaatcgtttg agcaattatt gcagggggtg gaagctattc cgataggagc 1683361 caatggactg ctatacactc cttatttggt tggtgaaaga acgccgcatg ctgattcttc 1683421 tattcgggga agcttgatcg gaatggatgg agcccataat agaaagcatt ttttgagggc 1683481 aataatggaa ggtatcacat tctctttaca tgaatcaatt gagctattcc gcgaagcggg 1683541 aaaatcagtt catactgttg tttctattgg tgggggagct aaaaatgata cgtggctgca 1683601 aatgcaagct gatattttca atacgagggt aattaagtta gaaaatgaac aagggccagc 1683661 tatgggggct gcaatgctgg ctgcctttgg aagcggttgg tttgaatcac ttgaagaatg 1683721 tgcagagcag ttcattcgtg aggctgctgc attttatcca aaggcgcaaa atgttcaaaa 1683781 atataaaaca ctatttgatt tgtataagaa catttacact cacacaaagg atctcaatac 1683841 agctttgaag agctttcgaa aaaactaatg atgttattgt ctggagatca accgaagaac 1683901 aattaatgat caatcatcat caaaggcctt tgataacatg gctgccttct tttgaaaaga 1683961 tggtgagaat aaggtatcgc aacctttaaa cagtattgga gtatccagca gacaaaacga 1684021 acgagtggaa ccgtattttg tcagcgaaca cttcaagaag tggggaagct taggaatgcc 1684081 aatgggtaag atgtatgaaa ccgcgctaac gacggtagag ggatctcttg atttatgaag 1684141 aaataggaag gatgttaaca cacaaataac ccctcacatt gacgtgaagg ggtgtttttt 1684201 attgttacta tacagcggaa attttacagg ctagttgcat gattttagct tgttaagcag 1684261 aatggaacta gactctccat catctctttc tcattctttg gaaactgcat tctgctaggt 1684321 ttgctgcttt ttttaacaaa cagtgttttt ctatttcaca cagccattaa atcctctgtt 1684381 cgtcacataa ccgctcttac tccaaattga cagtttatct gattttgctt cttgctcatc 1684441 tagtctgaat tggtctatgt attttgtgtt aggctcatat acatatgcta ctctggccaa 1684501 tccctctttc aataatgtct cttgaacaga tttgccgtca acataaacgt atgctaacag 1684561 tcttccatac ttatctctgc gatcgccttt atcaaattcc agctgtagct taccgctgtt 1684621 gaccaattct ttatttcgtt tcgacgcatc ctcaccgtat ggttgaacac aagaatttgg 1684681 tttcttcgtc tcaggtgtat caacgagcaa gtagcgaact gtgtctttct ttccgttgta 1684741 aataacctta atcgtatctc catctattgc tctatctaat gtaacattga ccaatttctt 1684801 ctgatttttt gaatgaggcg tgccagcctt ttgttctgtc tgattatatt cattagagtg 1684861 agtatcttga gagacttgct ccgtcccatt agaatctgaa tggtttttgg ctgcgtgatt 1684921 tgatccgcaa gctgccaaag taatacttaa aacgattgcg atcatactga tcaaaatctt 1684981 cttcatattg attccctctt tatcattttc tcttttcgcg attaaacatc atcattataa 1685041 cgatatggac attttttgtg aatggaaaac ttcaagggaa cttataacac tccaaattgc 1685101 caatagttaa cttcacaacg agatgatcaa aacatcacca tcacatagcg gaaataaata 1685161 atcctgaaaa taatattgac tgaaaatgct tttagaatta tgataatatg agaaatgaca 1685221 ataatgtgac aaagacatta ctacaacata acaactaata gcttaggttt attctattgg 1685281 ttaaaaatgt aaacggttac aaatccagag gcgaaaatct aagatagaga tgactttagt 1685341 tttgactcaa tatccacact gaaagagctt attaagtatt cttaaaggca ggggaaatgg 1685401 atatgaatga acatcgaaat cgaaggttga aattaataat gatttcagca acttttggag 1685461 ggcttctctt tggatatgac accggagtta taaatggagc tttacctttt atggcaaggc 1685521 cagatcagct tgatttaaca cctgttacag aagggcttgt tacgagtatt cttttattag 1685581 gtgccgcgtt tggagcgttg ttatgcggaa gattggctga tcgatatggc cgccgtaaaa 1685641 tgatccttaa tctttccttt ttatttttcc tggcatcact gggaacagcg ttagcaccta 1685701 atgttttcat catggcggtc tttcgttttt tactggggct ggctgttgga ggagcctcgg 1685761 cgatggtgcc ggccttttta gcagaaatgg caccgcatga aaagagaggg cgtatggtaa 1685821 cccaaaatga actaatgatt gttggcgggc aatttttagc atatgttttt aatgcgatcc 1685881 tcggtgtaac aatggcaaat acgggacatg tttggagata catgctagtc atttgtgctg 1685941 taccggctat catgttattt gccagtatgc ttaaggtacc agaaagcccc cgatggctaa 1686001 tctccaaagg caaaaacagt gaggcgctgc gagttcttaa acaaattcga gaagataaac 1686061 gtgcagaagc tgaatgtaga gaaattcaag aagcggtaga aaaagataca gcactagaaa 1686121 aggcatcact caaggacttt tctacaccat ggctgcgccg tcttttatgg attggaatcg 1686181 gtgttgccat cgtgaatcaa attacaggtg tgaactcgat tatgtattat ggcacacaaa 1686241 tccttaaaga atctggtttt ggtacaaaag cggctttaat cgctaatatt ggaaatgggc 1686301 tgatatcagt tattgcagtt atatttggga tttggctggt cggaaaagtg agacggcgtc 1686361 caatattatt gattggtttg gcagggacga ctacagcgct cctattgatt gcgattttct 1686421 caattgtgct tgatggatct atggcacttc cttatgtagt gctttctttg accgttttat 1686481 ttcttgcctt tatgcaaggg tgtgtaggac ctgtgacttg gcttgtcata gcggaaatat 1686541 tccctcaaag gttaagagga cttggttctg ggataagtgt ttttttcctt tggatattaa 1686601 actttgtgat cggttttgct ttcccgatct tgcttagctc tgtaggtttg tcttttacat 1686661 tctttatatt tgtggcttta ggtgtattgg caatcggttt tgtgtacaaa ttcatgccgg 1686721 aaacaaaagg gcgtacactt gaagaattag aagagcattt tcgttctcga cacgatcata 1686781 atactcctga acaatcagtt attgaggtat aaatatgttg aaaatctctc ttcttatagg 1686841 agggattttt ttagtttcag aaaaaacaaa atccctctgg tagagggatt ttgattcagc 1686901 attttaagat gttctacacg tataatactg gagttgatac tttaaaaatc tcgccatctc 1686961 ttatataaaa acgagggatg cggcggctta atgtagacac gacttcatag ttaatcgtat 1687021 tgagcatttc agccacttca tcaacggaaa tctcggctcc tttttgctta ccgtaaatca 1687081 cgacttcatc tccttgttta ccttcaccgt tttctcctaa actgaccatg atcatatcca 1687141 ttgttactct tcccgccact ggcactcgtt ttccgcgatg aagaacaaac ccgcgattgg 1687201 aaagggcacg agaatagccg tcagcatagc caatcgggag tgtagcaatt acttcattag 1687261 gttctgcgat gtatgtagca ccatagctaa cggttcgggg ttctgtccgc atggttttca 1687321 cataagcgat gcgtgccttt aaacttaacg caggttcaag cttaacgaga tttagttgtt 1687381 taatataggc tgaaggatat aaaccatata agccgatacc taaacggatc atatcagcgc 1687441 taaattccgg aaatgcgata gctgcagccg tgttgcacat atgcacggtg ggcagctcaa 1687501 tcccctgttt ttttaaaaag ctgagaaaac tgatgaattt ttcatgctgc agctttgtga 1687561 gtgttgtgtc cggttcatca gctgtcgaaa aatgtgtgaa aatccctgtc catctgagga 1687621 atttacttgc ctttaaggct ttcactacct ctaaaagttc ttcctttgtg cgtacaccta 1687681 atcgtcccat gccggtatcc acgttaatat gaatggccag ccggttagca ctcgcttctt 1687741 tttccaatat ctcgtttgct tctttcatcc aatcaacctg aaatgctgat aatgttatat 1687801 tccaagctgc tgacttcttt acacaactaa gggatgtaaa accaagcaca aggataggtg 1687861 ctgtaatccc agctttacgt aaaacgattc cttcctccac actggcaaca gcgagctcac 1687921 tcgccccgtg ttccagtgca tggcgtgcca cttctataga cccgtggcca taaccgttcg 1687981 cttttacaac agccataatt ttgctcttat gtggaatatg acggcggatc gctcgcaaat 1688041 tctttttaac ggcatcaaga ttgacttcga tccaaacttc tcggcaaagc tttatcatca 1688101 acgcttcctt ccttcttatg gattataaat accacctatt gccgcaagaa taaatgttaa 1688161 ttgttggatg attcgatctt attttattca actttatttg aaatcattca acagcaaatc 1688221 catgtgatac gagaaggtgc ctatcaatgt tcgaataata gcaagtacgg gatacatgag 1688281 gcttgtaagt ggggtgttaa tggatgcggc gaccgaggat tacaaaaatg attatttgtt 1688341 ttgggacatt tttttctaag ggtagatgat aacgagaaat ctaatcagga aatacttacc 1688401 gttgttatga acattgaaga accttttaaa tgagaagggc tgaggaaatt ctgtaaaaga 1688461 taatcggttg aaaaggcagt cgattccttg ttccataaac ctaacatcag agtatataat 1688521 tatactcgta ttcacaaaaa tcgtttaagt aaggggtata catgaatagg ggagttagtt 1688581 ttcaaatacc gaatgaatat ggaaattttc tatggagaat actgcagccg gtagaaatag 1688641 ctaattatag gtggcaaacg agtggggaat cttattttgt tgtagaagga gagctcgatg 1688701 atgaggagct ttttcatgac tacgaaattg ttgagggggc agtttttgag caacaattaa 1688761 aaacgaatca gtactatacc attttcgttg aactgaaagc atttccatat ggaaaaatgg 1688821 ttaatcaagt caatacatat gaagagtttg ctgacagtga ttgcgaactt gtccttttga 1688881 tagcagataa tagctacgtt tcgatttact gtaaaaacaa aaatatcatt gaaaaacttt 1688941 acttcaatgc tttacagcat gattttgaag acgttcaatt tataactgat gaaaatgaca 1689001 caagaacaag ccttactgta tgatactcaa taaaaattaa aggagctagt acatgacaat 1689061 gcaaattaaa atcaagtatc tagatgaaac acaaacaaga atcagcaaaa ttgagcaggg 1689121 agactggatt gatcttcggg cagctgaaga tgtaacaatc aaaaaagatg aatttaagct 1689181 tgtcccatta ggtgttgcaa tggagctgcc tgaaggttac gaagcacatg tcgtccctcg 1689241 ttcaagtaca tataagaact ttggcgttat tcaaacaaat tcaatgggtg ttatcgatga 1689301 gtcatataag ggagacaacg atttctggtt ctttcctgct tatgcattgc gtgatactga 1689361 aattaagaag ggtgatcgta tctgccagtt tagaatcatg aagaaaatgc cggcggttga 1689421 attggttgaa gtcgagcatt tgggaaacga ggatagagga ggactcggtt caacaggtac 1689481 gaagtaaaca aaataaatcc ttggctgtct tcatgctgtg tgattgatca atggaggttt 1689541 cagccaaggt acatataaat attatgtata aaatgaatat tttaatacga aggatttaat 1689601 taaaaacaaa gtttaaaaag ggaagttttg aaaaagtgaa atagtaataa ctaaagtcga 1689661 taaagaacct aaagatgtca aagaaacaat ttttctggtg ctttgctttt ttgaaggttt 1689721 acttagctcg tggataactg ccccccataa aagcatggat gctaaaatta taatacttat 1689781 atacataaag atgctccttt tattatattt acagttttta catttttatc gattttacca 1689841 catttaggat tgagttgtcg atgaaacaag catctctata aagaaatact tttatctaaa 1689901 tttttataaa taggggaagg caactaaaaa ctagtaatgc cactaataat aagccaagtt 1689961 aaatgacttg tgttcattaa taattgaatt ttacagcagc catgagcaca aaaaaatctg 1690021 agttcgtcga taaatatcat aaaaaagccc ccggtatgtc gccagggaat aaatagacgt 1690081 ttaagagatt tagtgatgtt ttttatatga ttcgacaaaa tcataataat gatcatcgtc 1690141 atcataatac tttttttcgt aatgataatc gtgatcatcg taatactttt tatcatggtc 1690201 atcatacttt ttgtcgtaat cataatgttt tttatcatga tcataatact tgtcgcaatc 1690261 ataatgcttc ttatcattgt cgtaatactt tttgtaatat gtttttttcc aagtataata 1690321 ctcttcttta tattttttat aataacccaa ttaaattcct cctttatgtt attcgaattt 1690381 aatttatgaa gtttaaatga tatggtatgg tcaaatgaaa taagaatagt aaaaagaggc 1690441 tgtttaaaac actttctgaa aaacaaaacg gatagctgtt tatgaaaata agagcgagag 1690501 agagcactca atcactgtaa aataatagta aagtgtatag agagattagt atacgtaaaa 1690561 agggactttc tcattgaaga atatttgaac gttatggtta agattcaaga gctctatgat 1690621 gtgatttttc acactgcttt tgaaggattt agagttagac atcaaaaaca aacagcaaaa 1690681 ccggctagaa acagatcata taaggaatga accgctgcca aatatcataa aaaagttgtt 1690741 aatgatcaaa tgaatgaaat tagagagaat ttattttaaa gaaagcccaa ttgcacatgg 1690801 acaaatgaca attgatattg aggtaaaata caatgcatta aatcagaaaa agctattgga 1690861 ggatttaatg tgtttagaca atttccaatt tggtatacac aaacacctga ctatttgaat 1690921 ttttatgtac cgcaatatca aaccatttcg tataatcctc aacaatgtta tcaacggtgt 1690981 atgtaccaaa ctggcggtaa ctatgagcta tgtgacagac tatgttatgg agaaatacag 1691041 gtgtaaaaga gggggattaa ctcctcttta aacacacagt gagtggaata agatcctcac 1691101 tttatctgca agtgcttagt atttgcgata atattgcatt cgtaataaat tatgcttagc 1691161 aactgaaaat gaaagaagga tatgaatagt catgacgcaa ttcgataaac aatacaattc 1691221 aattataaag gatattatca ataatggaat ctcagacgaa gagtttgatg taagaaccaa 1691281 gtgggactca gatggaacac cggcacatac tctaagtgta atcagtaagc aaatgagatt 1691341 cgacaactca gaggttccga ttttaacgac aaaaaaggtt gcctggaaaa cagccattaa 1691401 agagttgctc tggatttggc agctgaaatc taatgatgtt aatgatttaa acatgatggg 1691461 cgtccatatt tgggatcagt ggaaacaaga agacggaacc atcggacatg catatggatt 1691521 tcagctgggg aagaaaaaca gaagtctaaa tggagaaaaa gtggatcagg tagactatct 1691581 tcttcatcaa ttgaagaaca atccatcttc acgcagacac attacaatgc tgtggaatcc 1691641 tgatgaatta gacgcaatgg ccttaacgcc atgtgtatac gagacacaat ggtacgttaa 1691701 acatgggaaa ctccaccttg aggtaagagc acggagcaat gatatggcat tgggaaatcc 1691761 attcaatgta ttccagtata atgtgttgca gcgcatgatt gctcaagtga ctggttatga 1691821 gcttggtgaa tatatcttta acattgggga ttgccatgtg tacacacgtc atatagacaa 1691881 tttgaaaatt caaatggaaa gagaacagtt tgaagcacct gaactatgga tcaatcctga 1691941 agtgaaagat ttttatgact ttaccattga tgatttcaag ttaatcaact ataaacatgg 1692001 ggacaagctt ttatttgagg tagcggttta atgctgcctt tttattgtgc agtgaataga 1692061 tagcaggtat cctaatttca ttaagcaatc tggaagatga ataaaaattg aaggacaaac 1692121 acgtataata cataaaaaag attaactcta cagttaatct tttttattca gaagaaaata 1692181 tcctaacttt gaaactaaat acaaagtaaa agcaatcatt acagttctag atattacaat 1692241 tccatgaata gctagatcat atccagcagg tatcaacgca tttgtattac acataaaata 1692301 tatagatatt agaagtgcta caataactaa aatcattcca aaaagacttg ttttttcata 1692361 tttcatacca atttccaccc ttattaaagt taggtttaaa caaaagagct gaagaaacga 1692421 actatgacca gtatgctcca aggaaaaccg ccagacaatg ctggcggctt tttgctgctt 1692481 cgtttattta ttaacagaga tcgtaacgtt atttcctgca actgaaacct ttgcgaaatc 1692541 ctgtgtatct accacaggag tgacggcttt attgtcgata gtgatgttgt taaaagaggt 1692601 cgaaaaggtt gctttgatcg catcacgctg gctttcatac gaaacagccg cggtagcaag 1692661 tgttttccat tttgaaatcg tgccgatgtt ggttccttga atttctgtga taatccgtcc 1692721 ggtgtagccg tcattgttcg ttccccaaag ggtcatgcgc gtattgccgc ttaaattttt 1692781 atagattgtc atttggactg tgcttccagg gcggaagcct ttattgtatg tgaatttgtc 1692841 ttttccttcg atgtacgttt cttcattttt ggacccaacc ttcatgaggg gcttccagac 1692901 gttgtattgt ttgctgtact gaagcccgat atcggcttca gttccgcttg ttgccctaaa 1692961 gccagaataa atatagggag tagagaccga gtcgttgttt ttgacagttt caggaagcac 1693021 gattttagct gtaaaaacgg cgcccgtact gttcaggtag acacggccgc cgattccgtt 1693081 aggcagctcg gatgctgctt ttgcgacttg agcgtctgcc gcgggtaaac ctggtatacc 1693141 tgatgaaagg gttccgaaaa gaactgctgt tcctactgca cctgcaatca atactttttt 1693201 caccaaaatt cccccttttg atagtggttt cgccatttat tataccttat tttggaactg 1693261 gatttacgta tataaatcga caaaatattt cattttgaat gatgtaaggt cgaaacgctt 1693321 cgccaatctg aaagctatat acctttatca gaggaaagaa tgagatcaca ttcgttttaa 1693381 ccgatttgaa attttcctca aaataaaagt acaaatgctt aaagaaacga ttattaaaag 1693441 aatgcccgct atcgtttcca agcctgtaaa aaagaggtga cgtttcatca atgtctgtcc 1693501 ttgtaaaatg ataaaagcac agataccgac taagaaaaga aaacaaatac ttaggattgc 1693561 taacgcttta cgtgagtatg ttttcatttc atctttaaaa tacagcaata cgaaaataaa 1693621 gcagataaca ttggctattg ttctaatcac ctcaaagctt ttcatgacaa ctgatataaa 1693681 tagacaaagt aaaatgagat aaaatacgat gtttctatac aaaaaacctc tccttttatg 1693741 taggatcctc aaagagttta taaaagtttc tttgtaactg caataaattg aatgcgctca 1693801 cttatgaact aactaaacta tgtactaaat attcactatt ctttttcaga ttcagtcacc 1693861 aaggttttca tagaaaggga agcttcagaa atatacatat agtgcacaaa caaaaaagac 1693921 ccggcaatag ccgggggaaa gtaaaaacga ggagatgtta atggcgttta gtagtgtttt 1693981 ttatgctttt tatactctac aacataatca tagtcttttt tatcgtgatc ataatatttt 1694041 ttatcatagt catcatattt tttgtcgtaa tcacagtcat aatctttttt atcatattcg 1694101 taatacttct tataatacgt ttttttgacc gtataatact cttctttgta ttttttgtaa 1694161 taacccatat atactcctcc tttattttta ctacgcttta ttatacggcg agtagatttt 1694221 gcggcttgga cagttaaaat catagaagga aaaaagggct gtccaaatga tagaaaaaga 1694281 cagatgacac aaaaacaaat caaaataaag agccgatttt tcatcggccc aaacgattta 1694341 tcctacattt gtttgtcttc tttgttttct gagtcatttt ttctgatatc ctgagtcagt 1694401 ccgcttgttg cttgtttaaa ttctgataag gcttttcctg ctgcacggcc aagcgccggc 1694461 agtttatcag gcccaaatac taaaaaaccc acaaacaaaa taacgagtat ttttgtgaag 1694521 cttaattcca tatccttttc cccctgattg aagtacaacc ttttaaacaa attataagag 1694581 atagcagtac aaatgggaat gcatttattt tgaacatttt aaaaccagca caaagacgga 1694641 ttcataaaac ggctgctgct gaatataatg tccaatgcca cctgcctaag aagcaggagg 1694701 caggctggat caattatgta gctctgccgg aaatgataca aacgtagcgg ctatcattga 1694761 catagaggag tggtgtagct gatgagattc actaaggtag ttggattttt gtctgtttta 1694821 gggttggctg cggtttttcc attaacggca caagcagaaa aagccggaac tgcgggggct 1694881 ggagagtggg ataagttggg gacttacaca tatacttact caagtccgac ggtatactcg 1694941 accggaggag attttagagt gtgcctttca ggaagcactc ctttttctgt ttcactgcac 1695001 ttatatgagg atgatcccgg tgacaatcct gatgattatg taggggcaaa ctatttttca 1695061 cccggagaat gccacacctt tggcagtatt ggaaaatttg tagatgggag caataacaag 1695121 gccgagttct ttgttaccga ttactctggt aaatctaaaa ctgttacgtt ttatgattga 1695181 tggactcaaa ttgtgaagta taacccttgg aaaaaaacaa aaaagagaga tacctctctc 1695241 ttttttattc ttcgacagcc ttacgaagcc gttcatttac aatgccagtc cagccgccat 1695301 ccatcttacc gcgaacgacg gagcttttct cgtttgcttt gccgatcact tcattcggct 1695361 ctttccagcc gctgtgaata agggtaaacc ctgtcttttc ccccaagtct tctaattgaa 1695421 aggtaacgac ccatccttct gtatcccatt caaaagaaag ttcagttgga gcttgaacag 1695481 ccaaaacttt acaaggggac ggcccaaacg gcgattgtaa gtgaaattct tgtccttctt 1695541 tgagctgaaa gtcattgggc ataaaccact tggcaatgcc ttctgaagta gagactgtct 1695601 cccagacttt ctgaatggga gcctccagag taatgctttt tgtaatatcc ggtaatgcat 1695661 tttcgttgtt ttgagccatt tcgtttacct cttgacatat gatgtttttt caattcaatc 1695721 atataataac taataagatc atgtccatag cgtgcattat ttatgctaga gctgctgttg 1695781 aacagcgtgt cagtcgccag tctgatctgt gaatgggaga attctgcatg cgcgaaaaag 1695841 agagagaggt gtatgttgtc atttcgttca ttcttgtttg cagccgcaac tgttatgttt 1695901 gaactgggat tcctgttcag ccaatttatt ttgcgatttt tgttttaata gtaaatgagc 1695961 cattttctaa aacaggaggt tttttatgct tggaaaaatc aaagcagcca ttgataatag 1696021 tccagggaag ccggccagaa ttttagttag tgaaaaagcg tttcagcaat tagaggaaga 1696081 aatgcgcttt gtttacgttt ccaaaccgaa aacgataatg gggattcctg tggaagtttc 1696141 agatcaggca gaaagcttca agctggaatt ttagttttcc cagactgcta aaaggctcat 1696201 tttgtgttaa ttatgcaaaa tggtcaggtt gatttcttta aaagcatgat gaaatgttca 1696261 tcatgctttt ttattgagaa aaaagacgaa cataaaaaat aggtatacgg gaaaaataat 1696321 cctattagag agaggggaac tgacagatgg ataacatgat atcaacactt actgactgga 1696381 atgtgtggtt tcaagcgtta gtagtatttc tcgttccata tgtaatctat aaagtgttta 1696441 cttggattca tgtataagaa ggtgcaatga tgaggtggcg gaacaatcag tacaaaacac 1696501 agaagcagca taaatcagat tattcgacag ctgaaaagca ggatcaggat gtgttaaccg 1696561 gtaacatcgg atacgactta gaacatgtaa aaagaaaaat aggacataac ggggacgttc 1696621 atttccgtga gcttgaaatc actcaattac atgtgaaagc ggcattgatc tttgttgaag 1696681 gactgtctga tcaggacttg attaataaag gactatcagt gttagtcatg aatcaaccta 1696741 atcaggtaag cgatgaaatt tctcaatccg gcaaaggtat tttaacttcg aaacagataa 1696801 aaaatcaaat cgtatcaatc ggtgatgtca tagattcaga gaaaatcagt gatatcgtgt 1696861 tgaatgtttt catgggttcg acagcgcttc tcatcgatgg aataccgcag gcctttcttc 1696921 tgggaactgt aaaaaaacaa aatcgaagta tcgaggagcc gctttcagaa gcgcttgtca 1696981 gagggccgcg cacaggcttt acagaagagt tgagtacgaa tacagctctt ttgagacagc 1697041 aaggaaaaaa tgatcaatta acattgcaga gatttgaagt aggaacacga ttaaaaaagg 1697101 atttaattat cgcttatatg aatgacattg cagatccaaa agtagtcgag gaagtaagaa 1697161 aaagagtgag agggattgag atcgatcatt tgccggagtc aggctacgtt gaacagttaa 1697221 ttgaggataa ttatttgagc ccgttcccgc aagtacagag tacagaacgt cctgatcgcg 1697281 tcataagcgg attaatggaa ggaagagtag ctattctgct tgacggcact ccgtttgctt 1697341 tgattgttcc agtcactttc agcatgatgc ttcaatcgcc tgaagattat tatgaacggt 1697401 ggttcccgag ctcgctcatc agattgctga ggttcatcgc agcaatgata acgttattcg 1697461 cacccgcttt atatatatca tttatttctt ttcatcctgg gttaattccg accaagctgg 1697521 cgatttcaat ttccgggacg cgccaaggtg ttccgttccc atctctgatt gaagccttat 1697581 ttatggaagt cgcgattgaa attttaagag aggcggggct tcgtttgcca aaaccaattg 1697641 gacccgcaat aggcatagtt ggcggattaa tcatcgggga agcagctgtg caggcgggga 1697701 ttgtcagtcc aatcatggtc attgttgttg cgctcacagc aatttcttca tttgccatcc 1697761 cgcattatag cacaggtata gcacttcgga tgcttcggtt tggcgcgatg ttttgtgcgg 1697821 cggtgtttgg attgtttgga gtcattatgt attatctgct gctaagcagc catgtcgtaa 1697881 agctaaagag ctttggtgtg ccatacgcaa gtccggcagt gccctatcac ttaaaagatt 1697941 ggaaagactt tgttatcaga atgcctcttt tagtcatgaa gcgccggcct aaaatgatga 1698001 atacagataa tacaaaacgg gtgaagtgat gaactcgaca ggatggtgat aaagtctcat 1698061 gttcagccca accagtaaaa tcacaaccgc tcaggcaacg attatcatca ttaattatat 1698121 gcttgctgcc ggagttctta cgctccctcg gacagtaaca gaacaaacac aatctcctga 1698181 tggatggatt tcagttttat taggcggggt cctagcggta atagccggga tgattatagc 1698241 taaattaagc cagcagtatc ctaaggagac cttttatgaa tactcccgac atattgtagg 1698301 aaaatggctc gggcatctga tcagtattgt ttttattact tattttctgg cactcggtgc 1698361 atttgaagtc agagtcatgt ccgaaatcgt ggattttttt ctcctcgaag ggacaccttc 1698421 ttgggccatc attatgacag ttctttggat tgggctttat tcaattacac aaggcctaga 1698481 tccgattgca cggctttttg aaatgatttt tccgattacg gtcatcatct ttttaacgat 1698541 agccctcatg agtttaggca tatttgagat caacaatttg cgccctgtat taggtgatgg 1698601 aatcatgccg gttcttagag gtgtaaagac aacgaacctt tcatttacat gttcagaaat 1698661 tatgttcatt ttagtagcat ttatgaaaaa gccgaaaaat gcggtgaaag cagttgtgat 1698721 cgggacaggc gttgtgacca gtttttatat gattacgatg attatggtca tcggtgcact 1698781 atcagttgag ggagttgtga cgagaacatg gccggggctt gacctgatga gaagttttga 1698841 aatacctggt ttaatatttg aacggtttga atcatttctg cttgtgattt ggattatgca 1698901 gctttttgcc acgtttatta tcacttttta tgcagcttcc ctgggagtct cacaagtttt 1698961 taaaaagaaa cccctttcat gtatgtttgg gctgcttcct gttatatata tcctctcttg 1699021 catgccgaaa aatgaaaatg acgtctttat attgggcgat acggtcagtc atatcgcttt 1699081 gtatatattt ggcgctttgc cgattttgct gttagtcatt tcgaaatgga ggaaaagagg 1699141 tgaaaagtaa actaaaacgt caattgcctg ctatggtcat agtatgtctg ctgatgattt 1699201 gcgtaacagg atgctggagc agtcgggaaa tagaagatct gggtctcaca ttcgctatcg 1699261 caattgataa aggaaaagaa acgaacactg aaaaagagtt aaaagaagag ggcgggagct 1699321 atccgaaaaa agacaacatt acgctgacct atcaatttgt taatgaaaaa gcggcaggcg 1699381 cgggcacaag cgggggaggc ggtagcggac aaggagcgca aaaagcgtac attaatataa 1699441 gtgaaacagg ggattcatta cagcagatcg gaagtgaggt tgcattaaga cgggaccgag 1699501 aagtgtttag cccgcattta aaagttgttg tcatgagtga agatgtgctg cacacatttc 1699561 ctatcgacga aatgctggat caattttttc gtgataatga aatcaggctg agctgtcttg 1699621 ttttatctgc taaaggggaa gcaagagacg ctctccagct gaaagagaac ggagaaattc 1699681 cggcatttcg gctgattgga ttaggtgaaa atgaacataa agtttccaga attcttcccc 1699741 ctatgacact cgcgaaacta attggaaaac tgcattctgg cagcagcttt ttactgcaaa 1699801 atgtggttgc ggcgaatgga gcggtcaagt attccggagc agctgtaatc aacggaaaat 1699861 cgaaaaaaat gataggcacc ttaaatgaat atgaaactga ggggattaca tggattagag 1699921 gagaagggaa aggcggagtt gtcaaaagtc atgataaaaa gagccaacag acgttagcgt 1699981 acgatatcaa taaaatcaaa agcagaattc agccaatcgt aaaagggaaa gatatttcat 1700041 tccatgtcga tattgaatca gaaggcgatt tggttgaaaa ctggaacaca aaagaggcgt 1700101 tggacaccca gtttatagat cgtctcgaaa cgactattga aaacgaggta aagaaaatag 1700161 ttggtcaggt attaaaaaaa attcagcatg attataaagc agatgttgcg ggttttgatg 1700221 aatcttttag acttacatat cctcacttat ggaaaagggt gaaaaataac tgggatgaca 1700281 ccttcagtaa agccgacatc acatacagtg tgaacgtcac aattactcat ttcggcacgg 1700341 ttaaaactca gtaatgaatc ccaaggaaga gaaggaaacc tctcttctct tttttatgca 1700401 tttattagga taaagatact ttttttggag agatatacac ttttcaaatc gaccaatatg 1700461 ctaatatagg aattgcttga aatagaaggg agaaggggct gtgaggcaga aaccgattta 1700521 tgtagaaatc gaaatgaaat ctgatctgga tacactctgg gaatatacac aaaacccatc 1700581 actgcataag gaatgggatc tccggttttc aaatattacg tatttgaata gtcagccatg 1700641 cgaaaaacag aagtttcttt acgaaacaag ggtaggcttt ggattaaagg tgtcaggtac 1700701 aggagaaacc gtcggtgttt tcaacaaatg ttcatctgaa aggtcttctt cactggcttt 1700761 tggctctgat catccattat ctctgattcg gcatggaagc ggctactgga agtatataca 1700821 gagagaaaat gggaaaatga cgtttttaac acagtaccaa tacaaaacag cctacggact 1700881 gctgggaaga tggattgatc gtttattatt tcggccgctg cttggctggg cgactgcctg 1700941 gagctttgat gcattaaggc tttgggtaga gcaaaataaa catccgaagc gcttcattcg 1701001 atctgctatc atctatgtgt tcatgtgtct gtttttcagc ctgttttggt tctatcaagg 1701061 ctttgcaggt gttaagacaa gcatattgac aggaacagcg gagataggct tagctatttt 1701121 gtggctgctt cctttaaaaa gaaaatggat cattcatggt gtccaggctt gtatttttgc 1701181 tgggtttgct tgtctaggtt ccgaaatatt catgtgggtt ctattgagtg tgttttccgc 1701241 tgcaagcggc gctcttagcc tgcagctccc cagtgccagg cgcacaaaac gaaagagaaa 1701301 gaagtgacat tgtgagttcg atttatgaaa aatcaattat taactatcat ttgctgcatc 1701361 ccaagctgca gaaacggtac caattagacg ggtctcatac attcagcggg acgggaacga 1701421 tgtcagaaat aagcggaggc tcttttctgg ttagaatgct gttaaagctg ggtgtttttt 1701481 tcagatgctt cttttcagaa agaggcaaag acattccatt tacaatacaa aatagaactt 1701541 gtcttttgaa atcgcaacat acaggaatag aatggaatcg tacatttttc tttaaaggca 1701601 aaaaacgttt ctttgatgcg ttaatgatat atgacgagaa agaaaataga atacttgatt 1701661 tcttcggcaa acctcatctg ctgctgtctg ttttgacgtt cgaggcatct cttgacggct 1701721 ctcttacgat cacatcggga aagcaatggc tattgatatg cggaaaaaga atcccgctgc 1701781 cgaaatggct gaccggtaca tccgaagttt gcgaaacgtt tgatgaaaaa aagaattgtt 1701841 tcaccattga agtgcatgtg caaaatacaa ttcttggcac tcttttcttt tataagggaa 1701901 cgtttcagga ggaagagaga gaatcatgaa acgaaatggc atagtcagtg cgctttgttt 1701961 tattggattt cttgcagcag aagcaccgga tatttcagtg gcagaggcac tcgttttgtt 1702021 atccattcta tttttcgtgc cgggaatttt tccttttgtt tttcgtcaat ctccggttcg 1702081 tgctgctcag tttatggaaa acgggctaat ccagtgctat cctgtagccg cattctttgc 1702141 ggtgctggct ctagtgacgg aggttggggg tttcgcactt atctggtgga tgtacacagt 1702201 ttttaatgca ttgtatgcga tcctccgcct ttgggaaaca aagatacata gaatcgaaga 1702261 gacatcagtt ttgttcggtc ttatttattt ggcgggagga ggattttggt tttttgctta 1702321 tgctgcccat ttgcagatca tgcaatttgg ccctctcatc attttgctga ctgctgtcca 1702381 ctttcactat tctgcttttc tgatcccgat cttcaacggt ttactcggca gaaccattag 1702441 aaaacatcgg atgttgtaca gttggataac atgggtgatt ttgctttcgc cccttcttat 1702501 cgcactgggc atcacatatt caaaaacact tgatgtcatt gcggttagca tttatatggc 1702561 ggcgatttat cttcatgcat ttttggtgtt cacggcagct tttcgcacca agacggggac 1702621 atttcttatt cggctttctt ccgctgtttt aatgataacg attgctttct cgatgattta 1702681 ttcatttggt gtctttcggc aagaagttac attgaccatc aatcagatga tttggattca 1702741 cggttttgtc aacgcgtttg gtgttatctt gcccgctctc atagggtgga gaatagagga 1702801 tgcgaaacct tttgatgcag acagtgtaaa gacattcagc cgtatctacg gaaaaagaaa 1702861 gattggagaa gaatttttag ctaacattca agctgaaaat aacgctcggt acagcggact 1702921 tgtggatgat atgggcagcc tgcgttcaaa agatttttca ccagaaaaac tggcgccgct 1702981 cattctttcg ttttatgaac aaaccatcga atacaatatt aaagcaaaag taacatggag 1703041 cacgtggttt cggccgcttg caattattta cgaatggttc agcagaagaa tcggccaaat 1703101 acatctttcg acgaaccctg actggtatag gatgtacagc aagataaaag gtgttcattc 1703161 gaaaaaagac ggaagggaaa gagtacgtgc ctggattaga acaaatgaaa aaaacgaaac 1703221 catttttacc gctctttatt cagtgtatcg ttcaaatgga gaggggtata tgaatatttc 1703281 tttaccgctt ccattcagca gcatgacagg tattttaaaa ccatatcatc atcaggagaa 1703341 gctggtttta acaagcaggc ggagaaaaag cagagcgggg gatgagggga tttatctgca 1703401 aacaagagcg ggaacttgtc cgcttccttt atctgaaacc tttctgatag aagctgtaca 1703461 tgacaacaaa ttaaccgctg ttcatcatat gtggctgttt ggaataaaat ttctaactgt 1703521 tcattacagc attacacata ttaaccagcc tattgaaaga acctaacaca aagaagaagc 1703581 ttcgtctgcc agttgtaatg agatgaactg ttttaaaatt ctgcaccgca tcaagacagg 1703641 aaaggaaggg tttatggtgt tttatatcag tttatttctg attctttggc tggctgctgg 1703701 gtttgcagtg ggaatgaaac aagtgtatgt cgatcagctg tttgataaag ctgtgatcga 1703761 aagactggaa aaagaagcga atgatcatgg acatgctgac cggatgatca aacagcgcgt 1703821 cctttatatt gcagcagtga cagtaagcgg gtttatttct gtttattatg aaatgaaaac 1703881 aatcccgcaa aggcgaaaca taagaaaaat tgaaaaaaac atcatgaaat taaatcaagc 1703941 aaaaaaacga agaatgaaga gaaaataaaa agtgcacagg ccaaagggca ggtgcatttt 1704001 tgttttgtat ggaaaatggg ggaggtggtg ccagcttact tttcataaat tcaaaaatga 1704061 gaagaacagc gcccgggcta atggtatata atattgtgaa tttaacaaaa atttaacaag 1704121 gaggacgaga gaattcgtgc taaagcctca aagagaccta cattctgttg atttggactt 1704181 agaggcggag tagatgaaac cggccaaagt atccctgctc cgccgtttgc tccattcctt 1704241 gaagcatgtt gattgtaaca tagccaaacg ttttccatca actattaaaa ttgtaaaatt 1704301 attgatgatt tttatggtgt ttactccgat ttcttcaatt tatgctgaag atgtatatca 1704361 gaattttgag gaattaaaaa acaatgaaga tccttctgat tatggcgttg ttacgaaaga 1704421 aaccggaagc cctgttcttg ttttagctat tcacggagga ggtattgaag gcgggacaag 1704481 tgaagtagcg agagagctca gcaaagagta ctcgatgtat ttatttgaag gcttaaaatc 1704541 ggcaggaaac tcagtcctgc acattacgag cacacacttt gatgaacctc gggcccttaa 1704601 aatgacggga aatcatgaat atgtcatttc attacacggg tacgcagaag aagatcagca 1704661 gatcgaagtc ggcggtacag atcgcgtaag agcggcagat ttagttgaga aattgcagca 1704721 tgccggtttt cctgctgtat tgctcaatat ggaccatccg catgcgggcg ttagtccgaa 1704781 taacattgca aataaatcaa aaacaggttt aagtattcag atagaaatga gcacagggtt 1704841 tcgaaagtct ttgttcggca tcttttcttt aaaaagcaga gctgttactc aaaatgagag 1704901 gttttatgag tttacagaag tgatgttccg ttttctcaaa aatagctact gaaaaatagg 1704961 aggcgataag acagcctcct attccttatg cttctctttc gtttcgggaa acagctcgtc 1705021 cgcggcttcc gtttgatact gcaacgtgtt atctctcgct gacagttcat ttcggaaatt 1705081 ttcatcaagc acatttttca gtaaataccg atgaaaaaag tattcaaaaa cagtaagaca 1705141 ggcagcggaa aggagagccg ctccaaatgg tgagaaatcg tttcttgttt gggttaaaac 1705201 aaatacccaa agaataacga atgaaaggcc aaagtcagcc aatgaagctg taatattgtt 1705261 tgttctgggt aagacgagca tgtcaccaga aagataggaa acaaaaccta agaaaagtgc 1705321 aataaacatc acacttaaaa aggatgcgtg atagactctg tccaaaatca catataaaag 1705381 ggcgagagtg aaagcaatct ttgaagcaag cgcaatgata tgtttcattt gaccacctaa 1705441 attgttattt tttgaagaaa attcttgggc gtaaacaaat gataaataat gcaattcaaa 1705501 accattcata atggtcatgt tactatttta aacagtccgt ttttgtttac actggtattt 1705561 ttttcagctg tatgaaactt tcttatgaaa aaagtcgtat atgtggatga tcagctttca 1705621 aggggggaat gatttgtgga gataaaagga atcaatcact tgctattttc agtttcgcat 1705681 ttggatacat cgattgattt ttatcaaaaa gtgtttggtg caaagctttt ggtaaaggga 1705741 agaacaactg catattttga tatgaacggc atctggctag cgcttaatga agaaccagac 1705801 atcccgagaa atgacattaa gctttcttat acccatattg cttttacaat tgaagatcat 1705861 gaatttgagg agatgtcagc taaattaaaa agacttcatg tcaatattct gcctggcaga 1705921 gaacgagatg aacgcgatcg aaaatcaatt tattttaccg accctgacgg ccacaaattt 1705981 gaatttcata ccggaaccct tcaagacagg cttcgatatt acaaacaaga aaaaacgcat 1706041 atgcactttt atgatgaaac ggccttttga tagcacaacc atatttcata taaggttaaa 1706101 tttaaagaag ggtgttggtg gagactttat gtttggggaa ggtttctacc cgacttgttc 1706161 aacgatgcca tatcttttga actgcacaag tgattgggtg aaggtgaaat tgaaatacac 1706221 attacattac attttatatg aagaaagcga gctgttttat caaatgttga actaattaaa 1706281 ctatgtacta aattttcagt atatttcaat tgctttgccc cttaataaat ataaaaccgc 1706341 atccttccac gacctaaaaa atgaaacgtt tttaagaaga tggcgtctaa tattctaaat 1706401 gttcatattt tgataaaagt ttcctaaagg aaagaaaatt tcttgacttc aacaatcttt 1706461 tggtggataa ttatggtgta aacatgatgt tctttttcct cctattcggg ctcgcaccca 1706521 aaagtcaggg cgagcctgct ttttttgaac aacaaacccc ctctccgtaa aggaagaggg 1706581 ggttatttta tgcatctgat agatcaatag attaatggac ggttctgaac acgccaatca 1706641 ctttccctag aatgctgaca ttctgcaaaa tgataggttc catcgttggg ttctcaggct 1706701 gcaagcgaat gtgggtatcc tctttataga atcgttttac agttgcttca tcatcttctg 1706761 tcatcgcaac tacaatttcc ccattgttcg ctgtgttttg ctgtttaacg atgacatagt 1706821 ccttatcgag aataccagca tctatcatac tgtctcccat aatctccagc ataaatacat 1706881 gctcgtctgg aggaaccatg cggtcaggga gcggaaaata ttcttcaata ttttctactg 1706941 ctgtaatagg agatcccgcc gtgactttcc cgatgaccgg tacattaacg acctggcttt 1707001 gcggaatgtc tacttcttca tcaagaattt ctattgctct tggttttgtc ggatctcgtc 1707061 tgatcagccc ttttgtttcc aaacgggcca aatggccgtg gacagtagaa ctggacgcaa 1707121 gcccgacagc ctctccgatc tctctcacgg aaggcggata tccttttgat ttaacctctg 1707181 ctttaataaa acggaggata tcaagttgcc tttttgatag cttcgtcatt tttcgcacct 1707241 caaaacgtcg attttaagaa gattatagca tgattttcct tacagtacaa acataggttc 1707301 gaaaaaacaa ttgacagaaa cgtttgttcg tatatactga aattataaaa atgcgaacaa 1707361 acattcctgt tggaggttat gatcatgagt aaagaatcta ttatttttgt cggtctgttt 1707421 acagtgattt tgagcgcggt tatccttatg ctgtcatata caagcagcgg ccaagagctt 1707481 aatcagtatg ttaaaataga agtccagcaa ggcgacacac tctggtcaat tgctgatcag 1707541 gtagccgata caaaaaagat aaacaaaaat gattttattg aatgggtagc tgataaaaat 1707601 caacttcaaa cctctgatat ccagccgggt gatgagttag tgatcccatt gaaaaagaag 1707661 catcaggatg catatgaatt agcaactgta agatagagag gaaagagaga taaaatgaaa 1707721 gcactcattt atgcccgtgt aagcacaaat aaagaacagc aggaaacgtc attaaagcgg 1707781 caggaggagg agcttacggc cattgcagcg gagaacggca tggaagtggt caaagtgatt 1707841 tcagaaaaag ccagcggata tgaaatggat cgggatggtg tatttgagct gctcgatgag 1707901 attaagaacg ctgatattga tgtcattttg gttcaggatg agacaaggct cggacgggga 1707961 aacgcaaaaa tcgcactgct tcattgtatt tatagagaag gtgtgaaagt ctatacaacg 1708021 gctcatagag gtgaactgga gttatcggag gctgactcaa tggtcttgga aatcgtcagc 1708081 attgtggaag agtatcagcg aaagattcac aacatgaaaa tcagacgggg aatgaaacgt 1708141 gcagtaaaaa acggttttaa accgcaaaaa aacttaaaaa accaacatgg gaacagtgga 1708201 aaagaaaaaa tagaggtgcc aatctcagag atcgtccgcc tgagagcgaa taaactgacg 1708261 tttgctgaaa tcgcggctac cctaagaggg tttggctatg atgtctctaa agcaaccgtt 1708321 caccggcgtt ttcaggaata catagagaat gaagagactg cagagtgaat cagttgtaaa 1708381 actttttttg atctagtact atatagacaa aatgcaataa aggagtttaa catgatttca 1708441 aacgcgaaaa ttgccagaat taatgaactt gctgccaaag ctaaagctgg cgttattaca 1708501 gaagaagaaa aagccgaaca gcaaaagctc cgtcaagagt acttgaaagg ttttcgttct 1708561 tctatgaaga acacgttaaa aagtgtgaaa atcattgacc cagaaggcaa tgatgttaca 1708621 ccagaaaagc taaaaagaga acaaagaaat aacaaacttc actaatataa gaggaatacg 1708681 gcaatatcgt attcctcttt tgcatatact ataatcaaaa ctcttatgtg acaaaattca 1708741 acaagtttct ctcaaattta agctgaaaca gttgagaaaa agtcgtcaga catttatgat 1708801 gtaagggtac aacacataag gaaggggatt tttatggata caattgaaaa gaaatcagtt 1708861 gctaccattc gcacactgtc aatagacgct attgaaaaag caaattctgg tcacccaggg 1708921 atgccgatgg gagccgctcc aatggcatac acgctgtgga caaaatttat gaacgtaagt 1708981 ccggcaaacc ctggctggtt taaccgtgac cgttttgttt tatctgctgg acacgggtca 1709041 gcactattat acagcatgct tcatttaagc gggtttgatc ttagtattga agatcttaag 1709101 ggattccgcc agtggggcag caaaacacca ggacatccgg aattcggaca tactgccggt 1709161 gttgatgcta caacaggtcc gcttggccaa ggaattgcca tggcagtcgg tatggcaatt 1709221 gctgaacgcc atttagcgga aacatacaac cgcgattcat ttaacgtagt cgatcattat 1709281 acatacagta tttgcggtga tggtgattta atggaaggta tttcttctga agccgcttca 1709341 ctcgcaggcc atcttcagct tggccgtctg atcgtactat acgattctaa tgacatctct 1709401 cttgatggag acctcgaccg ttcattctct gaaaacgtga aacagcgttt tgaagcaatg 1709461 aattgggaag ttctttatgt tgaggatgga aacaatattg aagaattaac agcggctatc 1709521 gaaaaagcac gccaaaatga aaagaaacct acattaattg aagtgaaaac gacaatcgga 1709581 ttcggttcac ctaaccgtgc cggtacatcc ggtgttcacg gtgcgccgct tggtaaagaa 1709641 gaaagcaaat taacaaaaga agcttacgcg tggacatatg aagaagactt ctacgttccg 1709701 tcagaagttt atgagcattt cgctgtagct gttaaagaat caggtgagaa aaaagaacaa 1709761 gaatggaatg ctcaattcgc taaatataaa gaagtttatc ctgaacttgc tgaacagctt 1709821 gaactggcaa tcaaaggaga gcttccgaag gactgggatc aagaggttcc tgtgtatgaa 1709881 aaaggaagca gtttggcatc ccgtgcatct tccggtgaag ttctcaacgg acttgcgaaa 1709941 aaaattcctt tctttgtcgg aggttctgct gacctagcgg gatcgaacaa aacgactatt 1710001 aaaaatgccg gtgattttac agcggttgat tactcaggca aaaacttctg gtttggtgta 1710061 cgtgaatttg cgatgggtgc ggccttaaac ggtatggcgc ttcatggcgg tcttcgtgta 1710121 ttcggcggaa ctttctttgt cttctctgat tacctgcgtc ctgcgattcg ccttgcagcg 1710181 ttaatgggcc ttcctgtgac atatgtcttc acacatgaca gtattgcggt tggtgaagac 1710241 ggtccgacgc acgagcctgt tgaacagctt gcttcactcc gtgcgatgcc taacctttct 1710301 ttgatccgtc cagcagacgg caatgagaca gcagcagcat ggaagcttgc agtgcaaagc 1710361 actgaccacc caacagcgct agtgcttaca cgtcaaaacc ttcctaccat cgatcaaaca 1710421 tctgaagaag cattggcagg agtagaaaaa ggtgcatatg tcgtttctaa atctaaaaac 1710481 gaaacacctg acgctcttct catcgcttcc ggatcagagg taggtcttgc aattgaagcg 1710541 caggctgaat tggcaaaaga aaatatcgat gtttctgttg tcagcatgcc ttcaatggac 1710601 cgttttgaga aacaatctga tgaatacaaa aacgaagtcc ttcctgcaga tgtgaaaaaa 1710661 cgtcttgcaa ttgaaatggg ctcatcattt ggatggggca aatacacggg gcttgaaggt 1710721 gacgttctcg gcatagaccg attcggtgca tctgctcctg gtgaaaccat cattaacgaa 1710781 tacggcttct cagttccgaa cgtagtgaat cgagttaagg cattaatcaa taagtaagct 1710841 tttgaaagag gatgagtcaa atcatcctct ttttcttgtt tatccgacaa aaatagtatt 1710901 ggctgtttaa cagtaataga caattctttc ttttcttctt ttgtataata gagagcaaat 1710961 gaaatgctgc tggaaaaggg gatgaaaaga tggaacgtca ctactatacg tacctgatca 1711021 aagaggaatt tgccaatcac tatttcggcc gggaatcggt tatgtttgag ctgtttcaag 1711081 actatcattg gacaagcctt gaaaagcagc agtatgaaat gacagagaaa cagattcaat 1711141 atattacaca accaatcccg attttacata tgcatcagcg gttaaaaatg aatttaaaca 1711201 agacggatta caggcagctg gattatattt atagaatagc tttgccgaaa gcaaaaggcc 1711261 acgcgacgtt tatgatgaag gagcacatga tagaaattgt ggcttcggga gattacgagg 1711321 cagaaacgat attctttgaa gtgttaagaa aagtaagccc ttgcttttta gcaatggatt 1711381 tcaattcgaa gcgttacgga tggctaaatc cggtgaaaga aagaaatttt gtctaaaacc 1711441 gaagaaaaag agatgtaaat gttgtataat agcttttggt ttagtacact ttaaactaga 1711501 caacatgaag gaggaaataa aatgacttta tgggttggca tcctagtggg cgttgttgca 1711561 ttgctcatag gtgttgcact cgggtttttt attgctcgta aatatatgat gagctacctg 1711621 aaaaagaatc cgcctattaa tgaacaaatg ttacgcatga tgatgatgca aatgggaatg 1711681 aaaccttctc aaaagaaaat caatcaaatg atgaaagcca tgaataatca aacgaaataa 1711741 tacgtaaaga ttatgatata gagaaacatg gttataaaat aaaaaaccct tatacgggtt 1711801 ttttattttg caatcattca tcacccgcta ctgctcgaag gcgctgcttt tgatattgta 1711861 tgagaagatg gtcaagctcc tgactgagct ctatcgtaat atgagatgtc attccgttcg 1711921 ccatgacaat ttgcagcagc tctgctcttt ttttttcaat ttcttttaat agatgctctc 1711981 taatcacagg gatgtatcct ttcatacatt agatcttcaa agtgaatgtt tatattatat 1712041 ccatatttat actaattttc aaatgagaag gagtataatg tctcaatgtc aaattaaatt 1712101 atataagttt tttctgaaaa tagaaatcct tcaagtgaaa gtgttaaaaa aatgaaatga 1712161 ttttgtcata acttgaagga atgtcaaatc atgaagggat gatgacatgg gagacgtgaa 1712221 ttattttttg acattcggag cggggttttt atcctttatt tcgccttgct gcctgccgct 1712281 ttacccagct tttttgtcat atattacagg ggtcagcatg gacgatgtaa aaactgaaaa 1712341 gctgctgctg cagaaaagaa gcttgtttca tactttgtgt tttttgcttg gcttttcagt 1712401 catttttatt gctttaggct atggaacatc ttttattggc agcctgttta gggattatca 1712461 cgatgcgatt cggcaaattg gcgcgttgct tattattttg ttcggtttca ttacactcgg 1712521 tgtgttccgg cctgaggcta tgatgaaaga gcggagaatc cattttaagc ataaaccaag 1712581 cgggttttta gggtcggtct taatcggaat ggcatttgca gctggatgga caccatgtac 1712641 cggtccgata ttagctgctg ttatcacact tgcaggcacc aatccgggct cagcggtgcc 1712701 atacatgatg ttatatgtac tcggttttgc ggtaccgttt cttttattgt ctttttttat 1712761 cacaaagctg aagtggataa ggaagaacca gcttttcatt atgaaagctg gtggcgtttt 1712821 gatgattgtg attggtgtgc tgttattctt taattggatg agcctgatca ttattttgct 1712881 gtcagatctt tttggaggct ttactggttt ttgacggtaa attactttcg tactactact 1712941 aatccttttg tttttggtac aataagacta ttatctgtgg aaatcgattg ttggagggga 1713001 atatgacaag agttttagtt gtagacgacg ccaagttcat gagagtgaaa atcagagaga 1713061 tcttggaaga ggcaaattac ataatcgcag gcgaagcggc ggacggtgaa caagcagctg 1713121 acctgtataa aaaactgcgc ccggaccttg tgacaatgga tattacaatg ccggtgaaaa 1713181 acggcataaa agcgcttcgt gatatcttaa cctttgatcc taaagcgaag gtcatcatgt 1713241 gcaccgccat gcgccagcaa agaattgtaa cggaagcaat tgagctgggg gcaaaggatt 1713301 ttattgttaa gccgtttgag gaaacaaaag tgctggaagc tgtaagccgc gttatgggac 1713361 attaaagtca tttcttttca aaatggtttt ttttattgtt ttggagtata gtatatagta 1713421 tcaacactcc gagaaacaaa ggaatgataa gtatgatgat tatagtttca tcaattattg 1713481 ctgtgttaat ggctgtagct gtgatggtgg tcagaataaa gtcctctgac aagcctgttt 1713541 caccaaaaaa aatcattctt ccgccgattt ttatgagtac gggagcgtta atgtttttat 1713601 ttccggtatt ttgggtaact ggagcagagt ttttggaagc attcacttta ggtgtgattt 1713661 tctctatttt tctaatcaaa acttctaagt tcgaaattaa aaataatgaa atttacatga 1713721 aacgctctaa agcatttgtt tttatattag tcggtctttt ggtgatcaga atcgtgatga 1713781 aatcgatctt gagcacatca attgattatg gtgcactgag cggaatgttt tggattctgg 1713841 ctttcggtat gattgtgcct tggagaatcg ccatgtattt atcatatcga aaacttcata 1713901 acgagctgca gtcatctaat attcaaatga attaaaaaac ctttcctctt gtcaggaaag 1713961 gttttttatt tgagaagggt ctgataaggt tccaaatcga tttttttgtc ccgcagatgc 1714021 ctttttaaga aggtatggtc tcttttagga gttgcgagaa tatagccttt gatcataagt 1714081 tgctgatcaa tctttgctac cttttctttt aatgcaagct caccgatttt gcctgcgatt 1714141 ttagcttttg ctgcatctct gaacagctct ggcacgggcg cagtcaattc atctagaaac 1714201 tgtttgtttt catcgttcca taaatgtctg ctgttttcaa tatagtaatc ctgccaatca 1714261 agctctgatc tgccgtcctc ttttggtaaa cgctttaaaa actttcgaaa catgaaaaaa 1714321 ccgccgattg ataataagac taccatcatg attacccaaa acagaataaa ccataaaaac 1714381 catccttcca gcatcaatca ttccccctta ttctaaccat attgtatacg aagagagatt 1714441 agaagaacac agtaaaaaaa gaatagaaaa aagtgataga cgtctagtca aaagagatag 1714501 tagatcatat tctattgtat agtgaatctg ctatttggcc atgggagagt cactagaggg 1714561 tatttgacga taaatggacg gaaaaaaagt cactttcata ataggggatg aaagtgactt 1714621 tttatgttta gctgagagga aattgaagag aaaaagaaga gccatcttct gtttctttat 1714681 tgacggcgac tgtgagtatt tgattttcgc attcgacttg aatgtttttg tcattaaaat 1714741 aaaaaggaag catcatttgt ttttcaaaag tctgtcctga cgatttgaca gttaagatga 1714801 actcgcatcc agaaagggta actgttactt gtgtaggctg taaaaaagtc agatccgctt 1714861 ctataatata ctgctgactt gtttcatata aatcaatagg caatgtttcg tcgtaccagg 1714921 cgaaggggtc ttcaaaaaat tgccgaagcc attcatccat actatcgaaa tcattcgcat 1714981 cgttgcgttt tgaatggttc atggaagcat tcctccacat atcaaccttg ctttacatca 1715041 tatgcggtgg attataaatg ggtgaacgca taaaaaaaca gacactaagg tctgcttttc 1715101 ttacatatca tggcttgagt tgtgcttttg tcttgtatgg tttcggtttt ttactttttt 1715161 gcttccgctt agaggctcgg gttggccggg attgtgtcct ttaggggcgt ttttatgcat 1715221 atctttactt gtattcttat tggtcataaa atgagaacct ccttaaaaga gttcggtgtt 1715281 attgattggt ttttcttttt ttgttatttt ggcgttctgc ttcagtcagt acaagctggt 1715341 cgttttcaat atagccggcg cctttgcctt ggctttttgc gtcattcatt ccgttaatga 1715401 cgtgattcgc ttttcttttg accatcatta tcacctcaat cataatatgg cttcttttat 1715461 tgtgttatat gagagagcgt aaacagtaaa aattaccggt acatttttct cataagtcga 1715521 acttattgta tttaataaaa acattgatat ttacttatgt atgattttgt tttaatatga 1715581 aattgtgaga aaattgtgat ggaatgtaat gttcatctga gaatgatctg atctgaaggg 1715641 ggattttgga gaatggcaaa cgagcaaaaa actgcagcaa aagacgtttt ccaagcgaga 1715701 aaaacgttta ctacaaatgg gaaaacatat cattactact ctttaaaagc gttagaagat 1715761 tcaggtatag gaaaggtttc gaagcttcct tattccatca aagttctttt agaatcagta 1715821 ttgcgtcaag ttgacggctt cgttatcaaa aaagaacacg tggaaaattt ggcaaaatgg 1715881 ggaactgccg aattaaagga tatcgacgtt ccgttcaaac cgtctcgtgt tattttacaa 1715941 gacttcacag gggttccggc agtagtagat ctggcttcac tgcgtaaagc aatggcagct 1716001 gtcggcggag atcctgataa aatcaaccct gaaattcctg ttgatctcgt tatcgatcac 1716061 tctgtacagg tagataaagc gggtacagaa gatgcattag cagtaaatat ggacttggaa 1716121 ttcgaaagaa atgcagagcg ctacaaattt ttaagctggg caaagaaagc gtttaacaat 1716181 tatcaggcag taccgcctgc aacaggtatt gtgcaccagg tcaaccttga gttcttggca 1716241 agtgttgtcc atgccattga agaagacggc gagcttgtaa cgtatcctga tacgcttgtc 1716301 ggaacagact cacacacaac aatgattaac ggtatcggtg ttctcggctg gggtgtcggt 1716361 ggaattgaag ctgaagcggg aatgcttgga cagccttctt acttcccagt tccagaggta 1716421 atcggcgcga aacttgtcgg caagcttcca aacggaacaa cagctactga cttggcgtta 1716481 aaagtaacac aagtgctgcg tgaaaaaggc gttgtcggta aatttgttga attcttcgga 1716541 ccgggaattg ctgaactgcc gcttgcagat cgcgcaacaa ttgcgaatat ggctccggaa 1716601 tacggtgcta catgcggatt cttcccagta gatgaagaag cgcttaacta cctgcgcctg 1716661 actggccgtg atcctgaaca tattgatgtt gttgaagcat actgcagaag caatggcttg 1716721 ttctacactc cagatgcgga agaccctcaa tttactgatg tggttgaaat tgacctgtct 1716781 caaattgaag caaacttatc gggtccaaag cgtcctcagg atttgatccc gctatctgct 1716841 atgcaggaaa cgtttaaaaa gcaattagtc agccctgcag gtaaccaagg attcggttta 1716901 aatgctgagg aagaaaataa agaaattaag tttaaactcc ttaacggcga agaaacagtt 1716961 atgaaaacgg gtgcgatcgc cattgctgcg attacaagct gtacaaatac atcaaaccca 1717021 tacgtgctga tcggcgccgg actggtagcg aaaaaagcgg ttgagttagg gcttaaggtg 1717081 cctaattacg tgaaaacgtc acttgcaccg ggttctaaag ttgttacagg atatcttgtg 1717141 aattcaggcc ttcttccata catgaaagag cttggcttta acctcgttgg gtacggctgt 1717201 acaacatgta tcgggaactc aggtccgctt tcaccggaaa tcgaagaagc ggttgcgaaa 1717261 aatgatcttc tgattacgtc tgtcctttcc ggaaaccgta actttgaagg acgtattcac 1717321 ccgcttgtta aaggcaacta tcttgcttca ccgccgcttg ttgtggcata tgcgctggct 1717381 ggaacggtaa acattaactt aaaaaccgat ccaatcggtg tgggcaagga tggtcaaaac 1717441 gtatacttta atgatatttg gccgtcaatg gacgaaatca atgcacttgt taagcaaact 1717501 gttacgccag agctattccg caaagagtat gaaacagtat ttgatgacaa caagcgctgg 1717561 aacgaaattg aaacaacaga tgaagcttta tataaatggg ataacgattc aacttacatc 1717621 caaaacccac cattctttga agagatgtct gttgagccag gcaaggttga gccattaaaa 1717681 ggactgcgtg ttgtcggtaa attcggcgat tcagtcacaa ctgaccatat ttctcctgcg 1717741 ggggcaatcg gaaaagatac gcctgccgga aagtatttgc aagaaaaagg tgtttcacct 1717801 cgtgacttta actcctacgg ctcccgccgt ggaaaccatg aagtcatgat gagaggaaca 1717861 tttgccaaca ttcgcatcaa aaaccaaatc gcaccgggta cagaaggcgg atttacgacg 1717921 tactggccga ctggtgaagt aacatccatc tatgatgcat gcatgaaata caaagaagat 1717981 aaaaccggtc ttgtcgtatt agcaggaaaa gactatggta tgggatcttc acgtgactgg 1718041 gctgcaaaag gaacaaacct tctcggcatc agaacggtca ttgcagagag cttcgaaaga 1718101 attcacagaa gcaatcttgt attcatgggt gtgctgccgc ttcagtttaa acaaggtgaa 1718161 aatgcggata cactcggctt aacgggtaaa gaagtcatcg aggtagatgt tgatgaaaca 1718221 gttcgtcctc gtgaccttgt gactgtaaga gcaatcaatg aagacggcaa tgtaacaact 1718281 tttgaagcag tcgtccgctt tgatagtgaa gttgaaattg attactaccg ccatggcggc 1718341 atccttcaaa tggtgcttcg tgaaaaaatg aagcagtcct gatgaatcaa taggaagaga 1718401 aggcatttcg ctttctcttc tttttatgac acaatgtgct gcggaggtgg catatgctga 1718461 aaaaatggct cgcagggatc ctgcttatca tgctagtcgg ttatacggga tggaatttat 1718521 atcaaacata cagcaaaaaa gaagtcggaa ttcaagaggg gcaacaagca cctgattttt 1718581 ctttgaaaac gctatcagga gagaaaagct ctttacagga tgcaaaaggc aaaaaagtgc 1718641 tgctcaattt ttgggcaact tggtgtaagc cgtgccgtca ggaaatgcct gcgatggaaa 1718701 agctgcaaaa agagtacgcc gacaaacttg cggttgttgc ggtaaatttc acttcagctg 1718761 agaaaagtga gaaacaggtc cgagcgtttg ctgatactta tgacttaacg ttccccattc 1718821 tgattgataa aaaagggatc aatgctgact ataacgtgat gtcatatcca acgacatata 1718881 tcttagatga aaaaggtgtt atccaagaca tacatgttgg caccatgaca aaaaaagaaa 1718941 tggaacaaaa actggatctt gattagattc agtttttttt atactcaaat atgcttacaa 1719001 gttttcagaa ttggaaaaaa taaaagaata tgcggaggtg agaagcgtga agaagatgag 1719061 aaaacgttct tttcatgagc tcgtcatgga aaacaaaaaa gagctgatga ccaatacaga 1719121 gtatttaaat cagcttgagg aaaagcttga acagcgattt aagcaaaaat aacctttaat 1719181 ttgtattcat gtttacccct ccttttgaga aacctatctg ttgaggaggg ataaacatgg 1719241 gaaacaacaa gaaaaacggt cagcctcaat atgctccaag ccacttgggt acaaagcctg 1719301 taaaatataa agccaataaa ggggaaaaaa tgcatgatac ttcaggacag cggccgatta 1719361 tcatgcagac aaaaggcgag tagcgaaaat tcgagtttat ttctaggagg tacatccgaa 1719421 tgacaaagaa ccaaaatcaa tatcagcagc ctaatcctga tgatcgttct gacaatgtgg 1719481 aaaaattgca ggatatggtt caaaatacaa ttgaaaatat agaagaagca gaagcatcaa 1719541 tggagtttgc ttcaggagaa gataaacagc gtatcaaaga aaaaaatgca aggcgcgaac 1719601 agagcattga agcgtttcgt aatgaaatac aggacgaatc tgcagcgaga caaaacggat 1719661 accgttctta aaaaaccagg gaaacctggt ttttttcttt ctgatttgat tatggtaaaa 1719721 tggggctaaa ttgacgttaa gggagcagag taatcttgca tgtatcaaaa aaagaaatag 1719781 aagtgcgtta tgcagaaaca gatcaaatgg ggattgtcta tcacgcaaat tatcttgtgt 1719841 ggatggaggt cggcagaacg gccttgatta aggacttagg ctttttatat agtgatatgg 1719901 aaaaaaaagg cgttctgtcc ccagtcgttg atatcaatat ttcctataaa aagccgcttc 1719961 attacggaga aaccgcggtt gtacatacat ggatagagga ctataacgga tttaaaaccg 1720021 tctatggtta ccacatttat aatccggccg gtgagctttc catcaaagcc acctcatctc 1720081 atatttgtgt ggataaagaa agctttaagc caattcaatt ccgcaaagct tttcctgatt 1720141 ggcacacagc atatgaaaag gccaaaaaat agggaagtga acgggatatg gcgtttggtg 1720201 tgaaacggga ggaacttaac cggtggaaac aagcagtgaa aagaggagaa atcgcatttt 1720261 taacacatta ctggctggat gaccgatttc cagaagcaaa gaccgtgaca aaagccggct 1720321 gtgcagacat tgataagctg gttcagtggg gagcggcgta cgggttaaaa aaagaatgga 1720381 tccataagaa aagtgaattt ccccactttg atctgctggg ggaaacacaa aaatatattt 1720441 tggaacaaga aaacctaacc gatcatctta tacgatttca tttgtaaaaa aagaacgcac 1720501 atgaagtgcg ttctttttta ttggtattca aaaaccggtt catcagcgtc ttctgaatag 1720561 ctgacgagaa ggtcgtggtt atcaaagtac cataaatcac tttcttcaat aaagaaggta 1720621 atgccatcag cttctgcagt gactccagcc tcttgtgggg catctttcgc tacaccgaga 1720681 gaaaaaccct tttgaacgtt gctgcagcct ccatagcgga cgaaaaagcg aacctggtct 1720741 ccgctttcca aatcgagttc ttctttatac cagttcaatg cgtcttcgtt aattgtcata 1720801 ttcataacag aacacccctt tgttcttcat ttgaattttc tctattataa acgtattagg 1720861 ctattctgtg tcaaaagaga agttttttaa gcttataacc attttacttt aggttctgtt 1720921 ttattgataa ttcgtttaat gttcgctcgg tgtctgtata tcacaaaaat agtgagcagg 1720981 gtaacgacaa tcaataaata cgtatcatgg acaaagaaac tatatataac agtatagatc 1721041 cctgttaaca tcgatgagag agaaacaaat ttagtcaagt ataaaaagat gaagaatacc 1721101 gcaaccatcg tgataaataa caggggtgcg taaaatagca aaacgcctcc tgatgtcgcc 1721161 acggctttac cgcctttaaa tttggcgaag atgggaaaca cgtggcctaa aaccgcaaag 1721221 actcctgcaa gaagcgggtg aatatcaaca tgcatgagaa aaggcaatgc agttgccagt 1721281 gtccctttca aaatatctcc ggctatgacg accgaaccag cttttacacc caatgtacgg 1721341 aatgcattgg tagcgcctaa gttgccgctt ccgtgctccc gaatatcaat tcctttggca 1721401 agcttgccca caattaagcc agatggaatg ctgcctatca agtaggccaa aataatcaat 1721461 aaagcaatta acatctacat ttctcctttt tcaaattccc ttctttttat tttaacatga 1721521 gatgtcatga tctgatgata agtttttttg taaagtttgc ttacaaatca aatcaaacat 1721581 gcatcatatt ttgatttctc ctgttttgat cgtgtaaaat aagtgaaaaa ggagtgacac 1721641 acgatgcaaa acccttctaa agcggaaatt aaagagattc ttcaaagaag caaacgtata 1721701 gcggtagtag ggctttcaga ccgtccggat agaacgtcac atatggtttc aaaagcaatg 1721761 caggacgcgg gttatgaaat tatccctgtg aaccctacaa ttgatgaggc gctaggtgtc 1721821 aaagccgttt catctttaaa agagatagac ggtccgattg acatcgtaaa tgtattccgg 1721881 cgctcagaac agcttcctgg agtggcggaa gagtttttag agacagatgc gccagtattt 1721941 tgggcacagc aagggctagt taatgaggaa gcataccaga tgctaaaaga aaaaggcaga 1722001 acggttatca tggatctgtg cataaaagtg gcacacgctg taacaaaata ggtgcagaac 1722061 tgcaaaaatc cttgtaaatt caaggatttt tgctttttaa ttttaagata ttgtttgcgt 1722121 attacggtga aacagataca ataaagcttg aacagctttt tttgaatacc ttgtccagct 1722181 gggtttcggc cgttcgattt gcgaaggtct gctgctttat atataataaa caaacatacg 1722241 ttctcatagt gtaaaaacag cactagccga tgttttgaga agaactgatt cgttagctct 1722301 atgttgcgat tgcaaacata ttggttataa tgaggagtcc aaggcagtac tggctcgagg 1722361 cgaggtttat aaaaaatatc ttatatacaa atgatgtgta acactgaaaa gagaaagaca 1722421 atgttagttt ttgaaagggg tttgtacgtt tggctagaaa acagcaattt gattacaacg 1722481 aagatgccat acaggtgctc gaaggccttg aggctgtcag gaaaaggccg ggtatgtata 1722541 ttggctctac tgacgcgcgg ggtttgcacc acttggttta tgaaattgta gataactctg 1722601 tcgacgaggt gcttgccggc catggagatc acataatcgt caaaatacat aaagacaata 1722661 gtatttctgt acaggataga ggccgcggca tgccgaccgg aatgcataag ctcggcaaac 1722721 caacccctga agtgatttta acggtgcttc atgccggagg gaaattcggc caaggcggct 1722781 ataagacaag cggcgggctc cacggagttg gtgcatcagt cgtgaatgct ttatctgaat 1722841 ggctgacggt taccattgag cgggacggtt ttgtctatca gcagcgattt gaaaatggag 1722901 gaaaaccggt tacatctctc gaaaagatcg gcaaaacaaa aaagacggga actcttacac 1722961 actttaagcc agatccaacg atgttcagca caaccactta taattttgaa acgctctctg 1723021 agcgcttaag agagtctgcg tttttgttaa aaggactgaa aattgagctg attgatgaac 1723081 gcaatgacca gcgtgaggtc ttttattatg aaaacggcat agaagcgttt gttgcttact 1723141 taaatgaaga aaaagacgtc ttgtctgaag tggtctcgtt tgagggtgag catcattcta 1723201 tagaagtgga ctttgcgttc cagtttaacg atggttattc tgaaaatatt ttgtcgtttg 1723261 tcaacaatgt cagaacaaaa gacggcggga cgcatgagtc aggtgcaaaa actgcgatga 1723321 cgcgtgcttt taatgaatat gcgcgaaaag tggctttgct gaaagaaaag gataagaacc 1723381 ttgaaggcac cgatataagg gaagggcttt cagccattat ttctgtccgc attcctgagg 1723441 agcttcttca atttgaggga caaacaaaag gaaagctcgg taccagtgaa gcaagatcag 1723501 cggtggatgc gattgtttca gagcagcttg cttacttttt agaggaaaat cgggacaccg 1723561 caacgcttct tgtcaaaaaa gcaatcaagg cgagccaggc gcgcgaagcg gcacgcaaag 1723621 cccgtgaaga agcaagaagc ggcaaaaaac gaaaaaaatc agaagcgact ttaagcggaa 1723681 agctgacgcc tgcgggttca agaaacccgg caaaaaatga attgtatctc gttgagggag 1723741 attcagcagg cgggtcagcc aagcagggac gagaccgcag attccaggcg gttctgcctt 1723801 tacgcggtaa agtcattaat acagaaaaag ctaagcttgc tgatatcttt aaaaatgaag 1723861 agatcaatac gatcattcat gcgatcggcg ggggagtcgg ggcagatttc tcaatcgatg 1723921 acatcaacta cgacaaaatc atcattatga ccgatgccga tactgacggc gcccatattc 1723981 aagtgctgct tcttaccttt ttctatcgct atatgaaacc gctcattgag catggcaagg 1724041 tgttcattgc gctgccacct ttatataagg tcagtaaagg aagcgggaaa aaggaaatca 1724101 ttgaatatgc atggtctgat gaagagatgg gggatgtcct gaaaaaagtc ggcaaaggct 1724161 ataccattca acgatataag ggtcttggag agatgaacgc agaccagctg tgggaaacga 1724221 cgatgaatcc ggagtcccgc acacttgtta gggtcaaaat tgacgatgcg gcacgtgtag 1724281 agagacgtgt gacgacgtta atgggagaca aagtagagcc gcgcagaaag tggattgaga 1724341 aaaacgtcgc tttcggctta gatgaagaaa gcaatatttt agaaaatgaa aacttatcgg 1724401 tcgctgagga ggtttaatga ttgtcacagc cagaattatt tcatgattta ccattagaag 1724461 aggtgatcgg cgaccgtttt ggacgctaca gtaaatatat tattcaagac agggcgctgc 1724521 ccgatgcgag agacggatta aagccggtac agcgcagaat tctgtatgca atgcatacag 1724581 atggaaacac gtttgataaa aacttcagaa aagcggccaa aacggtcggt aacgtcatcg 1724641 gtaactatca tccgcacggt gacagctcgg tttatgaagc aatggtgcgg atgagccagg 1724701 attggaaagt tcgtaatgtg ttaatcgaaa tgcatggaaa caatggaagc atcgacggag 1724761 atcccccggc agccatgcgt tatacagagg cacgattatc tccgatagca tctgagcttc 1724821 ttcgggatat tgacaaaaac acggttgaat ttgtgccgaa cttcgatgat acaagcaagg 1724881 agcctgtcgt actcccggcg atgtttccta acctattggt caacggatct accgggattt 1724941 cagcaggata cgcgaccgac attccccctc atcatctggg agaagtcatt gatgctgtca 1725001 ttaagcgtat tcaaatgcct tcttgctctg ttgacgaact catggaagtt attaaagggc 1725061 ctgattttcc gacaggcggt attattcagg gcgttgacgg gataagaaaa gcttacgaaa 1725121 ccggaaaagg aaaaatcatt atccgcggaa aggctgaaat tgaaacaatc agaggcggac 1725181 gagaacaaat tgtcattact gaaattccat ttgaagtaaa taaagcaaac cttgtaaaaa 1725241 aaatggacga gttccgtatt gataaaaagg ttgaaggcat ctcagaggtt cgtgatgaaa 1725301 cggatcgaac agggctgaga gtggtcattg aactgaaaaa agaagctgat gccaaaggca 1725361 ttttgaattt cttatataaa aatactgatt tgcagatcac atataacttc aatatggtgg 1725421 ctatccataa ccgccgtccg atgctgatga gcctgccgtc tattttggat gcatatatcg 1725481 gacaccaaaa ggaagttgtc acaaaccggt ccgtttacga gcttcaaaaa gcaaaagaca 1725541 gacatcatat cgtagaaggg ctcatgaaag ctttgtctat tttggatgaa gtgattgcaa 1725601 caatccgttc ttctagcgat aaacgtgacg ctaaaaacaa tttgatcgcg aaatatgaat 1725661 ttacagagcc tcaggctgaa gccatcgtgt cattgcagct atatcgttta accaataccg 1725721 atatcacagc gcttaaggaa gaggcagaag agctcggtaa aaaaattgaa gagctcgaat 1725781 ctattctgag caatgataaa aaactgctaa aagtgattac aaacagctta aaagcactga 1725841 aaaagaaata tgcagatacg agacgctccg tgattgaaga aaaaattgaa gaaattaaaa 1725901 tcaatctcga agtcatggtt gcatctgagg atgtatatgt aaccgttacg aaggatggtt 1725961 acctaaaacg gacgagccag cgctcatttg ccgcttccaa cggtcaggac ttcggaatga 1726021 aagatacgga caggatgctg catcagtttg aaatgaatac gacagacgtg ctgctgctct 1726081 ttacgaacaa aggaagctac atctattgtc ctgttcacca gctgcctgat atcagatgga 1726141 aggacatggg ccagcatttt tcaaatctaa tcactattga ccgtgatgaa acgattgtaa 1726201 aggctatacc gataaaagaa tttgatccgt cggcatatct tctattcttt acgaaaaacg 1726261 gtatggtgaa aaagacagag ctcactcatt ataaagcaca gcgttattct aaggcacttg 1726321 tagccttaaa tctgaagggt gaagatgaac tgattgatgt acatgtaaca aatggggaaa 1726381 gccagatctt tatggccact cacttagggt atggtctatg gtttggagaa gacgaagtga 1726441 atgtagttgg cgcgcgtgcg gcaggtgtca aagggattaa cttaaaagag gatgactttg 1726501 ttgtctccgg tgagattctt cagcaatctg attcaattgt cttgttcaca cagcggggag 1726561 cggttaaacg catgagtctt tctgagttcg agaagacatc ccgtgcaaaa cgcggtgtcg 1726621 taatgctaag ggaactgaaa aagaatcctc accgtgttgt agcactgttc gcttgcggtc 1726681 ttgaacagcg actaatggca gaaacagaaa aaggcgacag aaaagaactg cagacaaaag 1726741 agttgcggac aaacgacaga tacagcaatg gctctttctt ttttgatgaa gaggaatcag 1726801 gcaaggttac agctgtttgg cgccttcata cagaacaata ataaaaaacc cgctcatact 1726861 atatgagcgg gtttcgtttg ttttttatca gctttcatgg ttggtgaata gatctgttac 1726921 agcatgaatg acttcaatcc cctgccatac aaataaattc agcgctgtga aagaaaataa 1726981 gcctaaaatc accattctta agataaacaa catgtttaac agcctcctca tattttcgtt 1727041 acataatcgg gtgatgttga acatgaagtt tgccgaaata agacgattga taaaatttgg 1727101 ccagtataaa gctttttttc cgctgacgtc tgcgggagta tcccgtactt ttgctttcag 1727161 cggtcagcag cagaacagcc attgcccata aagcggtcag cgtaaatgcc cctgtgatgg 1727221 atttcttctc atcatcagca ttttggccgg ctttcatctc atgcatttcc tgctggtcgg 1727281 ctacggcttt ataatgatgg ccgatatcaa aggcgtgggg aattgagaac aaatgaaaac 1727341 tggcaatcgc caagaataag atggatgctt tcaatatcgt tacttttttc aaatgatctc 1727401 cccctccttt aatattactg aatattttta taataatacc ccaatccatc ctaaaagtaa 1727461 acctgattta ttaaatttaa aaataaattt aactttgtta agtatatatc tttttgctta 1727521 tttttgaaag agaaaacttc ttttattagc gtatgtatac ccggtttatg gtgtgaataa 1727581 aaacatattt taaatgatat gttgtttagg atttattact ttatttatgt gtaaatcaaa 1727641 gagaaaggca agagaatggg aagaaatgat tacattgtta atagggtact ctttttttaa 1727701 agccagtttg caaggaatgt ttttattcgt aggaaaataa tagagaaggg gtcgacagag 1727761 taacatctgg ctatgacaat attcttctcg aaaaaacttc ctaattcgtc atattgtgat 1727821 ataataaaac tcgttatgtt aaaaaatcta acatcaaaat cgaattcgta ttgaattgat 1727881 gaaaacggga ggtaaatatg gagtcttttt tcaatagttt gattaatatt ccaagtgatt 1727941 tcatctggaa atacctattt tatattttaa tagggcttgg attatttttt accatacgtt 1728001 ttggttttat ccaattccgt tattttattg aaatgttcag aatagtaggg gagaagccgg 1728061 aaggaaataa aggtgtttca tctatgcagg cattctttat ttcggccgca tcccgagtcg 1728121 gcacagggaa tttgactggt gtagccttag caattgcgac aggcggacca ggcgctgtat 1728181 tttggatgtg ggtagtggct gcagtaggca tggcttcaag ctttgtcgaa agtacattag 1728241 cacagcttta taaggtaaga gacggggagg atttccgcgg agggccggcc tactatattc 1728301 aaaagggtct tggtgccaga tggcttggca tcgtttttgc aatcttaatt accgtctcat 1728361 tcggcttgat ttttaacgct gttcaaacaa atacaattgc tggagcattg gatggcgcat 1728421 tccatgtaaa taaaatagtt gtagccatag ttctggcggt tttaactgcg tttatcattt 1728481 tcggcggttt aaaacgtgtt gtcgctgttt cacagctaat tgtgccggtt atggcaggca 1728541 tttatattct tatcgcttta tttgttgtca tcacgaatat tacggctttc cctggcgtta 1728601 tcgctacaat tgttaaaaat gctttaggtt ttgaacaagt cgtcggcggc ggaataggcg 1728661 gcatcatcgt tatcggtgcg caacgcggac ttttttcaaa cgaagcagga atggggagcg 1728721 caccaaacgc ggctgcgacg gctcatgtat cccatccggc aaagcaaggc tttattcaaa 1728781 cattaggcgt atttttcgat acatttatca tatgtacgtc cacagcattt attattttgc 1728841 tgtacagtgt aacgccaaaa ggcgacggca tccaagtcac acaggctgct cttaaccatc 1728901 acattggagg ctgggcgccg actttcatcg cagtcgcaat gttcttgttt gcattcagtt 1728961 cagttgtcgg caactattat tatggcgaga caaacattga atttattaaa acaagcaaaa 1729021 catggctgaa catttaccgt atcgctgtta ttgctatggt tgtgtatgga tctttatcag 1729081 gcttccaaat cgtttgggat atggcggacc tctttatggg tatcatggcg ctgatcaact 1729141 taattgtgat tgcgctgctg tcaaacgttg cttacaaagt gtataaagat tacgcgaaac 1729201 agcgtaagca aggacttgat cctgtgttta aagcgaaaaa catcccaggg ctgaaaaacg 1729261 ctgaaacatg ggaagatgag aaacaagaag cataatataa atataaaaca aagctgcatt 1729321 caatagttga atgcagcttt ttcattattg gaaataaatt taatttttcg actcgaatga 1729381 aaaatgacgt gtaaagtccc aattcagtcc agttttcttt gttctatatg tgtcatgtgt 1729441 gtcttattca ttggaggtag agcaaattga caggctttta aacctcccca aaacaagaaa 1729501 ttaggttgat agacaatcat gagaaagatt tttacaatga gttcgtgctc ataagaagtg 1729561 tagagccaaa atgatgcgaa ggaggaaaag atcagatatg aaacggtcaa tctctatttt 1729621 tattacgtgt ttattgatta cgttattgac aatgggcggc atgatagctt cgccggcatc 1729681 agcagcaggg acaaaaacgc cagtagccaa gaatggccag cttagcataa aaggtacaca 1729741 gctcgttaac cgagacggta aagcggtaca gctgaagggg atcagttcac acggattgca 1729801 atggtatgga gaatatgtca ataaagacag cttaaaatgg ctgagagatg attggggtat 1729861 caccgttttc cgtgcagcga tgtatacggc agatggcggt tatattgaca acccgtccgt 1729921 gaaaaataaa gtaaaagaag cggttgaagc ggcaaaagag cttgggatat atgtcatcat 1729981 tgactggcat atcttaaatg acggtaatcc aaaccaaaat aaagagaagg caaaagaatt 1730041 cttcaaggaa atgtcaagcc tttacggaaa cacgccaaac gtcatttatg aaattgcaaa 1730101 cgaaccaaac ggtgatgtga actggaagcg tgatattaaa ccatatgcgg aagaagtgat 1730161 ttcagttatc cgcaaaaatg atccagacaa catcatcatt gtcggaaccg gtacatggag 1730221 ccaggatgtg aatgatgctg ccgatgacca gctaaaagat gcaaacgtta tgtacgcact 1730281 tcatttttat gccggcacac acggccaatt tttacgggat aaagcaaact atgcactcag 1730341 caaaggagca cctatttttg tgacagagtg gggaacaagc gacgcgtctg gcaatggcgg 1730401 tgtattcctt gatcaatcga gggaatggct gaaatatctc gacagcaaga ccattagctg 1730461 ggtgaactgg aatctttctg ataagcagga atcatcctca gctttaaagc cgggggcatc 1730521 taaaacaggc ggctggcggt tgtcagattt atctgcttca ggaacattcg ttagagaaaa 1730581 cattctcggc accaaagatt cgacgaagga cattcctgaa acgccatcaa aagataaacc 1730641 cacacaggaa aatggtattt ctgtacagta cagagcaggg gatgggagta tgaacagcaa 1730701 ccaaatccgt ccgcagcttc aaataaaaaa taacggcaat accacggttg atttaaaaga 1730761 tgtcactgcc cgttactggt ataaagcgaa aaacaaaggc caaaactttg actgtgacta 1730821 cgcgcagatt ggatgcggca atgtgacaca caagtttgtg acgttgcata aaccaaagca 1730881 aggtgcagat acctatctgg aacttggatt taaaaacgga acgttggcac cgggagcaag 1730941 cacagggaat attcagctcc gtcttcacaa tgatgactgg agcaattatg cacaaagcgg 1731001 cgattattcc tttttcaaat caaatacgtt taaaacaacg aaaaaaatca cattatatga 1731061 tcaaggaaaa ctgatttggg gaacagaacc aaattagtta agcttttttt tggcggacat 1731121 cagtaacgat gtccgttttt atcatctaat aggaggtttg cgttgtggat gaaatactga 1731181 aacagtatat ggtgctgtat aaaaaaatga gtaatatgat aaatggtccc gactatccag 1731241 gtaaggaaaa agacatccag catcaaaaag atcagatcga agtttacgaa aaacagctgc 1731301 agcaaggatt ttctacagat tatgactatg atgtgtttgc tgattctgtt atcaaatgcg 1731361 catatggcga tatgacgctg gaagatttag aagccgttta ttatggattg acaacaccat 1731421 ttttttgatt tgtcattcag cagtaaaatt tcaatttctg tctcactaac ttaagtatac 1731481 tttgatattg agacagaaat ttatttattt tgtttacttc ctagaatata tattatgtaa 1731541 actagaaaag atgaagaata aagctttgct gtttttatgt acatcctttc ttcttcctgt 1731601 aattcagcaa caaaataaaa aagcgatttc ccaatcggaa aatcgccaat tcagacactc 1731661 tattatttat gtgtgtcttt gtgctcttaa cgatttacaa caaatgttgt cacgctttga 1731721 gctggaagat gagcccaaaa atgattgcct gatacagtga gattcgttcc aggttgtaga 1731781 ttgctgctgc tgctcgtgat ccatctagat acgtttgaag cagatccatt ctgcaaaaca 1731841 aagttttggt tgactcctgt gttgctttta ttgatggcaa caataacgac cttgttgtca 1731901 cctttatagg ctgacacgta aacgttcgca ttagggtttt tcgttgcatc aatccttaca 1731961 tagccgggac gcacaaactt tgagaaatga gccatattgt agccgcgttt gctgatcgta 1732021 ccatcttctt tcataggtcc atatgatctt cggatgtacc accatacata agcttgaaag 1732081 tccccctcta ccatcgcatt gtgaatatgc tgtgaaacat ccaatgcctc aggccatcga 1732141 tccgccgagt tggtatcact gtttggatag tatacttccg tcatccaaag gtccttcccc 1732201 gctccttttt gtttgaaaag aggataaggg aattggctga cctgggtgcc gtacaggtga 1732261 gttccgagaa tatccatatt ggcaagagcc tgcggatcgt tcaagatcgg gtccgacaaa 1732321 ttcttcaagt attgaaatga ctcaggcgca atgacgcggg cattgatcga gccggcgttt 1732381 tctctcataa agcgaagtat ttcttgcggc gtccaccacg tccactcgtg agcgtaatca 1732441 ggctcgtttt ggaccgaaat cgcgtaaaga ttcacaccat tattcttcat gaaggtaaca 1732501 aaatcgttaa gatgctgcgc gtatgctgcg tacttgttgt atttcagccg tttagccgat 1732561 gtgtcaccat tccgattaaa ggtctcaacc atatcacttg gaggattcca aggagaagca 1732621 aaaacgattg ctccgtgttt gaccgcactc tttgcagtct ccacctcttt ataccaatta 1732681 tttcgatttt catctacatg aattcttaag attgaaaatc ctaactggtt ctgtccattg 1732741 ccaaaagcag tttctctttg agctgctgta agatccccag cccaagccgg atgattcatc 1732801 cctccaaaac cgcgaatcac ttgtttctct gcagatacat taactgttac atcacttgct 1732861 gccaaaactt cagtagcgcc tggccctaac atgactgaca gcatagtgaa acatactaat 1732921 agtacacaaa ttgttttttt tatgcgtgga atcatttatt cctctccttc gtcatgtgtc 1732981 ttttacggta ttaaaaaatc tgcatggcat atccataatg gcgggctgtt ccggtgctgg 1733041 cccgtacttc acccgcctcg tttttaagcg gtcccattac gagtactatc tttgcgtaaa 1733101 ctgccagtaa tcaaaattaa acaagtttcc tgtacctgtt ccggtaaata caaagaatac 1733161 tttgtgcaca ccggttgccc cgcttaccgc agtttctatt tccctccacg tttgcgctcc 1733221 gcctgttgaa ggcacattca gagttccaac aagcttaccg tctgcactgt cgaggcgcac 1733281 ttctattttc ccgcctaaag tggatgctac atttgcttta aatgacctgg caccgcccgc 1733341 tccgaagtct gcatttccta cagcaatcca gtctccattt tgaatgcttg ttacatgctg 1733401 attatttact ggcccgccgg gtgctgtgga cttctctgtc aaaatgcgtc cattccaagc 1733461 aaacgtttca gcttctaccc ggttatatgg gtttaaattg gaaatttgtg ttacacctgc 1733521 ataatttgcc gctacctctt gaatagatcc atctgcatta tgcaccagct tattaatatg 1733581 gggagagcgg tatcctttgc cggccccgaa cagagcggaa ctgacagttt gcgcatggta 1733641 caccacatac cactcgtttt taaaattgaa aacagcatga tggttgtttc cgccacctcc 1733701 gaaaaatgca cccggatttt tcaggaagtg ccctctatat gtaaagggac ccatgggact 1733761 tgaactggtc atgtagccga tctcacccgg gggtttatcg gccgggtgcg tgccgccgaa 1733821 attgatgcaa taggagtaat aatatgttcc gttatacttg tgcaatcccg aatcttcaaa 1733881 catgaaaggc gcatcaattg tagatgcact tccaacaaca ctcgtcatat caggccccaa 1733941 ttttatgact ctagccgttt taggattggc ccattgtccc tgcgttggat ttgaaacgcc 1734001 aggaacgcct ccgccggcat acaggtaacc ggttccgtcg tcatctacaa atactgccgg 1734061 atcaaaaagc catacaacac cagacattcc tggcgtactt ggcgttacga gcggttttcc 1734121 gattgggtcg gtccatggac caatcgggct gtctgcggtg agaaccccga tacctccgcc 1734181 gctgtttgcg aaataaagga agaatttatc cttgccatta atttttttaa ctgcgattga 1734241 cggtgcccat gacgcacctg cccattttgc aattccacgg cctccattag ctccattggc 1734301 acctgctacc ggaatggctc cgtggtctgt ccagttcacc atatccgctg aagatatgac 1734361 gaatactcta ttcaaattgg caaatgaatt atctttaatt gttccgttgc tattatattc 1734421 atagtcatca cttgacatat agatgtagac tcttccgtta taggtcagcg caaccggatc 1734481 cgctcccaaa tgatggtcga taagcggatt tgaattccct atatgttttg caattgtagt 1734541 actagtggca gcatacgcag acttcccaga taagcagctc aataataaaa ctagaatcca 1734601 taaacatacg ctacactttt tcctcatcac ttcacatcct cctttttcct taaaatgggg 1734661 gattttcttt tggaatttga taacaacagg tcacgaagat tgcacgcata aagtagccgg 1734721 aagctgttta gcaatgttcc cagttgttct gaaagctcat cttcatgtgt ctccattctc 1734781 tcttttcttc gaggagatcg caccactcct tcaaaattgt tcaaaaaaac ttccccattc 1734841 ctagcgacca ttgtccagaa aataaaaaga caggattgtt catggcctcc cactaatcac 1734901 attgaacgga gattacatca ttatccaaga tatcccttta tctaacatcc tacatcatta 1734961 aaaaaattgt gtatagaaac ttttggagga gttagtgttc gattctacaa aggaactgga 1735021 tacatttatt cattgataag atggggctaa cactccgttt atatttgtat gttttcagac 1735081 acaaaaaaca gccgttcaat gcggctgttt ttttcaagag tataagacta ttgagcggta 1735141 tacccgcttt ttcatgtttt gttcatattt tattaattgt ttattcaaca ctgtccgcta 1735201 tagtaatcca tatcaacaaa tatgactgcc actcgcatct tttatgaagg gaggttcgtt 1735261 acgctgaaag aaaaaataaa gacattaggc cgtttttgca ccgtaggcgt cggcaatacg 1735321 ctgatagatt ttggtgtctt ctttcttctt accgcttgtc atgtctctta tctgccggcg 1735381 cagatctgct cctatactgc aggtatcgtc aacagctatg tgtggaaccg gaattggacg 1735441 ttttgtgtga aacgtaaggc tgacgggaaa gagatcgtgc gttttctcat gattaatatt 1735501 gccgcgtcag ggatcacctt tttgctgctt tatttgtttc aaaattgcgg ctgctcgctt 1735561 ttggtgagta agctcgccgc cactatcggc ggaatgatga tgaattttat cggaaaccga 1735621 atctgggtat ttggagattc gctgaaaaac atacaggatc aggagtgaag atgaatgaga 1735681 aaaaaagtga gaaaagcggt tatacccgca gcgggtttag gaacgagatt tctgccggcg 1735741 acaaaggcgc agcctaaaga aatgcttcca atcgtcgaca aaccagcaat ccaatatatt 1735801 gtagaagagg ccgcagagtc aggaattgaa gatatactga ttattacagg gagaaacaaa 1735861 cgctcgattg aagatcattt tgatcggtcg gcggaattgg aattcaatct ccgggaaaaa 1735921 ggcaagacgg agacacttaa ggaaatgcag cagattgccg atttggccaa cattcattac 1735981 atccgccaga aagaaccgct cggattaggc catgcggtgc tgtgtgcgga gcattttatc 1736041 ggagatgagc cttttgctgt tctcttaggt gatgatatta tggtgtctga aacaccggct 1736101 cttcggcaat taatggatgt atatgacgtt tatggcacag aggttgtcgg tgtacagtca 1736161 gttctccctg aggatgtcag caaatatggt attataaata catcagggtc tcaagggcat 1736221 gtatatgaag tgaacgattt agtggaaaag ccttctcctg aagaagcacc ttcggaaatc 1736281 gcagtaatgg gacgttatgt gctgaattct tcgatcttct ccgttttgaa gacaattggc 1736341 agaggcgcgg gcaacgaaat tcagctgaca gatgcgcttc gtgaggtttg ccgtaaggag 1736401 ccgatccatg cccggctgct ggaaggaaat cgatatgaca ttggcgataa gctgggctgt 1736461 tttaaagcga gcaccgaaat cggcttaatg cgtcccgaaa tgagatctca gcttttggcc 1736521 tatttagaag atgtgatcaa acgggaaacg aaagaaatgc tgcggtaaaa aaattgtaac 1736581 catcttgctc gtcaatcagt catataatag tgaaaaagat taggacaggt tgtgaagaat 1736641 gtgggcagtt tgataagcga aattttaaca tggctgacga acatgggata tgcgggtatt 1736701 gcgattgggt taatgattga aatcattccg agtgagattg tattagctta tggcggctat 1736761 atggtatcgg agggcacgat tggatttatt ggcgcaatta ttgcgggtgt tatcgggggc 1736821 accattgccc agatctttat ttactggatc ggtcgctatg gcggcaggcc atttctggac 1736881 aaatacggga agtatttatt gattaaaaag catcatatcg atatgtcgga aaactggttt 1736941 cagaaatacg gcgccggagt tgtcttctcg gctcgtttta taccggttgt cagacatgcc 1737001 atatccattc cggcaggtat tgccagaatg ccttttctca aatttgtggt actgactgtg 1737061 cttgctatca ttccatggtc tatcctgttt gtttatttag gcatacagct aggaagccag 1737121 tgggatgatg ttgagaatat agcaggcact tatacaacac cgattatgat attggctgtt 1737181 gtcgtgatag ccctttattt tgtgattaag aaacgtacag ccatatttaa acgatagcta 1737241 gcggatatgc ataggggtga ctgacgctcc cctatgcata tttttttact tgcgatgttg 1737301 atttgccagc ttcagattct ccgctaaaaa tgcgacaaac acttcatccc gcacgagcga 1737361 tgcggcataa tttctcttaa taaaccattc tgcctcttca aacgctgcga atgtttcgtc 1737421 ttgggtttct ccgttaattt gaatattcca ttcgttgtct aaagggaaaa gaaaaaatct 1737481 catttgtgcg cgattttcat ataatgatcc attcgcagat ccctttagat tatagatgtt 1737541 acggaaggca tccggccgta caggatcaat acggaaagct tcagctacaa acaactcgta 1737601 tacttcatcg gttattgaac agccggacgc ttttgcatgc cctccgccgc catatcggcc 1737661 ggcgatttct gacacatcga tgtaatcatg aatggtgcgg agactgactc gttttgaccc 1737721 catgctcaaa atcgcaatgt aatcgaggtg cgggttatct ttccctagcc tgttccccag 1737781 ctctgaatgg tacgattcag cgtgaacgat gcctacacag tgttcgtgaa caaaggtttg 1737841 taccatttcc cttttctttc tgcggaggta gcgctcgatt ttttcgtctt ctaaatcaag 1737901 cagtttttct tcaaaatcat cgaagaaaaa ttcgtcatgc gtggaaaggc gctggatcat 1737961 ttttgcttca aattcatcga ttgacagcaa aaagaaaaga tcattaagcc gcttcgcctg 1738021 tttttgatcg taccgctccc actcccatgt atcgtattgg cggacgagct ctgtgaattg 1738081 atctaaggcg tttgtcggtt tcatgaagcc attttcaatg agatagccat ataaaagcga 1738141 tgtcgcggat gtgagccttc catcatcgta ttccacctgg acaaatcccc attcatgctc 1738201 attcaaatga agggctgttt tatgatggtc aatgagcttc actttgcccc ctgcatgaac 1738261 atactcattc aatctctctt cgttttcttc attgacggcg agatcggtga tgaataacgc 1738321 gtcctgtctg ttgctctcct tcgctttttc taaaaagtac tgcacctgtg cgtttaagcc 1738381 gttgacagag ttataccgga tctctacgtc ttttccgaac gccaattttg ctacgattcc 1738441 gcatcctact ccgtccaagt cgttatgtga atataaatga tacataatgt aggccccttt 1738501 ttatgataaa ctgacaattg ccgctagagg tgcggcagcc tttatttact attctaaaaa 1738561 accaagcgtt ttatgcaatg gtaattagtt gacataatgt tgttattgta aatatataaa 1738621 ggagcgcttt ttttgcgctc ctaagttctt gcttttacac cggataaacc ggatgctttc 1738681 gattggtaaa tgtcatttcc tttgtcatgt atgccttgag ccgtttggcc agctcatcac 1738741 gcagcgaatt ggctgggata acagcatcaa tgatcatttc tgaagccaga cggtagatat 1738801 tgatgtcctc tttgtattcc tcccgtttgc tgctgataaa tgcggctctc tcttcttctg 1738861 gcagctcggc gattttttta gcgtagacag cgtttacagc ggcctcaggg cccatgacgg 1738921 cgatttgggc ggttgggagc gctagacagc aatccggttc aaatgccggc cctgccattg 1738981 catacaaccc cgccccgtaa gcttttcgga caatgacaga gagttttgga acagttgcct 1739041 ccgacatcgc agaaatcatt ttcgctccgt gtctgataat cccagcctgt tctacttttg 1739101 tgccaatcat aaaaccgggg atatcggcta agaacagcaa tgggatatga aaagcgtcac 1739161 ataaggtaat aaacttagcc gctttgtctg ctgaatcgtg gaataagacg cctcctttta 1739221 ccttcggctg gtttgcaaca atgccgacag gctgtccgtg gattcgtgcg aggcccgtca 1739281 ataattccgg tgcaaataag gctttgatct caaaaaatga gtcttcatct atgacccgct 1739341 caatgagctc atgcatatca aaaggtgcgt tttgattttg cggaatgacg tcggcaagcg 1739401 gagtttcgaa gtgttttggc gggcgtttct catgaatggg cgctttttct tgaaaatttg 1739461 ccggaaagta agacaaataa gcccgcacca gctgtatggc ttcttcttca gtttctgcaa 1739521 gaatatctcc gcagccggag attgagcaat gcatacgggc gccacccatt tcttcgagag 1739581 acactttttc tccaataacc atttccgcca tccttggcga acctaaatac atggaggcgt 1739641 taccgtctac cataacgacg atatcacaga aggccggaat ataagcgcct cctgccgcag 1739701 atggtccgaa aagcagacag atttgcggaa tgcgtcccga taatttgact tgattgtaaa 1739761 aaattcttcc tgcaccgcgt ctccctggaa agacattgat ttggtcggta attcgggcgc 1739821 ctgccgaatc gactaaataa atgagcggac agtttaattt ttcggcgatt tcttgaattc 1739881 tgatgatttt ttcaactgtt tttgctcccc atgaccccgc tttcactgtt gaatcattcg 1739941 ccatgacgca aacggtttgg ccgccgattt tgccgatagc ggttacaact ccgtcagcgg 1740001 gaagcccgtc tgacatacat tccgcaaaaa aagcgtcttc tagctcaatg tcatcgtcaa 1740061 agagaaggga aagccgctct ctgacaaaga gcttgccttt ttcccgattg ctttgatgat 1740121 acttttccgc tccgcctttt cgaatccgtt cagcccgttc tgttcgttcc ttttcataat 1740181 ccatcagcat tgcctccctt ttatattccc ttgtatacgg cccgtctttt ttcttgaaag 1740241 gcctgaagcc cttctctcct gtcttttgtc gggatggttt gttcatacgc tttttgttca 1740301 atcgcaaggc ctgtagcaag atctgtctcc aatcctttat tgattgcaaa tttagcctga 1740361 cggacagcga tcggtccgtt ggcagaaatg gctgcggcca gttcctctgc ttttggcata 1740421 aggtcacaag gagccgtgac atgctctaca aggccgattt cttttgcttc gtgtgcggtc 1740481 acgcgtctgc ctgtataaat gaattctttt gcttttcctc tgccaatcag ccggggcagc 1740541 ctttgggtcc ctccagcgcc cgggataata gctaaccctg tttccggaag tcccagcaca 1740601 gctgcttcag ttgcgattcg aaggtcgcat gccaatgcca attctagtcc gccgcctaat 1740661 gcgcttccat ttatcgcagc tatgaccggc tgcggcaagg catcaagtaa agccgccgtt 1740721 ctttgaatga gagatacact ttccagaacc tgatcttctt tcagttttat ccgttccttc 1740781 aggtctgccc ctgcacaaaa cgctttttca ccggtgcctg tgaggatgac gcaacggatg 1740841 tttgagttaa attcaatttc ctggataatc atttgcaggt ttctaagcat ttccgctgaa 1740901 agagcatttg ctgcctgagg cctgtttaag gtgatcaacg ccatatgttc atttttaaca 1740961 gtaaaaagaa tagaatctcc cattgtatgc gtcctccctt ttatcaagat gatttaaaca 1741021 cctgtaaatt tctgctcggc agcggtttgc ccattttttc ttcaatccat ttggccgcag 1741081 atagcagttt ttctagcttt acatttgttt tgatatccat ctgttcaagc atgtacacga 1741141 tatcctcagt tgcggcgttt cctgatgaac ctggcgcata tgggcatccc ccaagcccgc 1741201 ctgccgagcc gtcgaacacc gtgatgccca tttggagtgc tgtgaccatg ttggccagag 1741261 cggttcctct cgtatcatga aaatgcaggg caatttgatt agccgggaat cgtgccaaaa 1741321 gagcttcaag tacagtttcc acttgggcgg gattagctgc tccaatcgta tctccaagcg 1741381 acagttcaga aatcccaaat tcaaatagag cttctgaaag gcgaatgact tgttcaatgg 1741441 ggacatcttt ttcgtacgga cagccgaaaa cagtcgagag gtaggctctt gttgtgaggt 1741501 ttgctttttg tgcgtcgttg tttacttgtt tgagtatatg gagggattca gaagtggatt 1741561 tattgatgtt ttttctgttg tgcgtctcgc tggcggacat aaaaacgcaa gcctcgttaa 1741621 tgcctccttc aagtgcattc tccagtcctc tttgattcgg gacaagtgcc gcgtacgtta 1741681 cccctttttc tcggtcgatg ccttttgcta catcgatagc atctcgaagc gccggaatcc 1741741 atttcgggtg aacgaaggat gtgatttcaa tatacgacag ccctgtccgg gaaagctggt 1741801 tgatccaggt tattttatcc tctgttgcga tccaaacggg ctcgttttgt aagccatcac 1741861 gcgggccgac ttctttgatt gtcacttttt taggatatgg catggtcttc ctccaaatta 1741921 ttgagtggaa ttgctcagtt cgagcagtac gtctccttca tttacaaagt cgccttcctt 1741981 ttttttgact tcttttacga ttccgcttct atctgcaacg atcgggattt ccattttcat 1742041 cgattccaaa atggctacct cctggccctt ttcgatttgg tcgccggctt tgacgtggac 1742101 tttccacagg tttcctgcca tttgtatgct aaccgtcatg acaactgcct cctttatagg 1742161 tgctgtttca aaaagtcagt cgtgacatcc ccttctttaa atgcctttgt tgccgcagcc 1742221 tgtatgagga gcggaaggtt tgttttgatt ccctctacac gatagtcgcg aagcgctgtc 1742281 tctagttttt caattgcttc tgttctggtt tggcctttga caatcatctt agcgatcatc 1742341 gggtcataaa aaggggtaac ggtgctgtct tttgctaccg cacattcgtg tctgactcct 1742401 ttttggtcag gaagtgaaaa cgcagtgatc gtacctggtg acgggaagaa ggtcttggga 1742461 tcttccgcgt atattcgaac ctctatcgca tgcccgttcc gttggatgtc tttttgggag 1742521 aatgtgagtg tatggcccgc agcaatccgc agctgctgct caactaagtc caggcctgtt 1742581 atttcttcag tcacggggtg ttcaacttgc agtctcgtat tcatttcgag gaaataaaaa 1742641 ttttgtttct ggtcaactat aaattcgatg gtgcctgcgt tcgtatagcc gattgccttc 1742701 gctgctttta ccgctgtttg accgatcttc attcttagtt catcgtctac aaatggagac 1742761 ggtgcttctt caatgacttt ttggtggcgc ctctgaacag agcaatcacg ttcaaacaga 1742821 tgtactgtat ggccgtgttg atcggccaaa agctgaacct cgatgtggcg cgcatgttca 1742881 ataacttttt ctatatacat agacccgtca ccgaaaaaat ctgctgcgcg ctttttgttt 1742941 ccctcgtacg ctttttttaa tgcttcttca ttttcaacac gctgcattcc gatgccgcct 1743001 ccgcccgctg aagctttcag catgacagga tagccgattt gacttgcggt gcggcaggct 1743061 gcctctatat ctccgaggga ttcagaaacg cccggcacca cagggacacc tgcagcctcc 1743121 attgcttttc gcgcttcaat tttgctgccc atctttgcga tgatatcagg ggaaggtccg 1743181 ataaacacga tgttttcttg cttgcagcgt tcagcgaacc ggctgttttc tgataacaat 1743241 ccatatcccg ggtggatcgc gtcggctttt gcttttttcg ccgtctttat gattctctct 1743301 atatttaaat aactttcact gactctcgat tccccgatca aatatgcctc tgtagcggct 1743361 tttgtatggg gcgcgtcctt gtctgcttct gaataaacag cgaccgtttt aatgccgaga 1743421 cggctgcatg ttcggataat tctcattgca atttcaccgc ggttggcgat cagtactttt 1743481 gtaaacatga tttcacctca ttgacttgat gataagttga acatttcaat cgttttttct 1743541 cgcagtttat atttttgaat tttgcctgag gccgtcatcg gatagtcatc cgtaaaaata 1743601 acataacgcg gaattttgtg gcgggcgatt ttccctttgc aataggcttt aagctcatca 1743661 ggtgaaacgc ttttaccgtc tttcagttta atccaggctg cagcttcctc cccgaatttg 1743721 gcgtcaggca caccaaccac ctgtacatct aaaacagcgg gatgctggta taaaaattct 1743781 tcaatttccc gcggataaat gttctcgccg cctctgatga gcatatcttt taatcttccg 1743841 gtgatgcggc agtacccgtc ttcatccatg acagcaagat ctccggtaaa cagccatccg 1743901 tcatgattga ttgcttttct ggtcgcatct ttgtctttat aatagccttt catgacgtga 1743961 tagccacggg tgcacagttc tccctgcatg cctctttgaa cttcttgaca tgtcccgggt 1744021 tctacaattt tcacctcagt atgtggcagg gcacggccgg ttgtttcgac tcttcttatg 1744081 aaggaatcat ttgctctcgt ttgtgtaatg actggcgagg cttcggtttg tccataggcg 1744141 atcgtaatgt ctttcatgcc catcctttca atcacagctt tcatcacttc acttggacag 1744201 ggagagccgg ccatgattcc tgttcggagc gtcgatagat catatgcatc aaaatccgga 1744261 tgatgcagct cggcgataaa catggtaggc acaccatgga gcactgtgca tttctctttt 1744321 tctaccgttt taaggacggt aacgggatca aattcttgca cgggtatcat ggctgccccg 1744381 acggatacac atgccaaaac cccaaggacg catccaaagc agtgaaaaaa cggaacaggg 1744441 atgcacatgc ggtcttgaga ggttaaagcc atacattcag cgatattagc agcgttattg 1744501 atgacattga aatgggtcag catcacgcct tttggaaacc ctgtcgttcc tgatgtgtat 1744561 tgcatattaa tcacattgtc tttatccagg ctgttcattc tctcttcaag ctcagcatct 1744621 gtcactgttt tcgccaatat ctctgtatcg tcccaatgat acatgccaga caatcgttta 1744681 ttgccaatat agatcagcgt ttttaaaaag ggatagcgtt cagatttcag ttggccgggc 1744741 tttgcttctt gcagttctgg aattaaactg ttcacgatgt ctggataaga agtgcccctg 1744801 tatgaatcca tgataataag cgccgcggca tccgattgct ttaacaagta atcaagctca 1744861 tgtgcttgat aattggtatt gacggtcacg agcacggctc cgatcttcgc agttgcgaac 1744921 tggacggcaa gccattcaga gatattagaa gcccatatgg cgacgtggtc tccttttcca 1744981 atccccatcc gcatgagacc tttagcggtt tgacggcaca gactgtcaaa ttgagcgtac 1745041 gtatagcgga tatttcggtc tggatacaca acagcatctc gatcgggata cgcatcagct 1745101 gtttgttcca gcagcctgcc gattgtggaa tggatgagtt cagccattca ttgttcctcc 1745161 tttcttaatg ataggaaagc gtttacattt ttattttaaa agctgtctgg cgatcacgag 1745221 acgctgaatt tcagatgtgc cttcaccgat ttccattaat tttgcgtccc gcagcatccg 1745281 ttccacccca tactctttca tatagcctga acctccatgg atttgaatgg cttgattgca 1745341 agctcttgtc gccatttcag atgcgaatag cttggcgtac gccgcttctt tggtgaacgg 1745401 gcggttatga tctttcagcc aggcggcttt taacaccatt tgccgtgcca gatcaatttc 1745461 catcgccatg tcagcaagct taaattgaat cgcttgaaag gaagaaatcg gctgtccaaa 1745521 ctgctttcgc tctttcgcat atgccaatga tgcgtcaagg gccgcttggg caatgccgac 1745581 tgcaagagca gcgatggaga ttcgaccacc atccagcgta tatagaaact gtttaaaccc 1745641 ttttgttgga tcgccaagta agttggccgc aggcactctt acatcttcaa gcaagatttc 1745701 cgctgtattc gaaccgcgga cgcccatttt atcgtacggg ctcgtaatcg taagtcctgg 1745761 tgtgtcagtt ggcacgatta atgcggagat gatgtttttt ccgtctttgt ttttgcctgt 1745821 tacggcggtt acaataactg tgcgtgcgta gcttgcatta gtgatccagc acttttcgcc 1745881 gttgattaca tactcgtcac catttgaaat cgcttttgtt tgagtgcctc ctgcatctga 1745941 gccggcattt ggctccgtca ggccgaatga tccgagtgct gtgcctgaag ccagcggcgt 1746001 caaatgcgtc tgtttttgct cttctgttcc gaagtagtaa agagggcttg cgcctagcga 1746061 gaccgctgca gcatagctta atccagtact gccgcaggct ttgccgactt cttcaaccgc 1746121 taaggcatat gaaatcgtat caccgccaga tccgccgtat tcttctggaa atggaatacc 1746181 catcagaccg agttcaccca tttttttaaa tgtttgcatc gggaactcgc ctgtttgatc 1746241 tacatgttca gcgtgaggag caatttcttt tttcgcaaaa tcttttacca tttcacgcac 1746301 catttgttgt tcttttgtca gctcaaaatt cacatcgttt cctccttcac atctttgtaa 1746361 catcctatta ggcgagttct ataatcattc cctgacaaga aaagtctgaa aattaaaact 1746421 gaatcatttt ttatgtgata atatcagcgg gatgagcaaa tacatgcagt aggcgcatac 1746481 catccatatc gtaaacgcaa taacttggcc ctttgataaa gccgggaaga tgaggggaag 1746541 attccaaagg gaaatcgtat ccatcaataa accgaccgct gatccccata tacctagctt 1746601 gatcaccgcg aactgtgatt gatcgagttt ttgatagaga aagaacacaa ggcataaaac 1746661 aagagcagtg cccgctccca agagaagaaa gttcggcaaa aaggcttctt cagccggatc 1746721 agtcaacaca gcatctccga acagcacaaa aaataatgtg gcacctaacc agactagaaa 1746781 tgaaaacgta aaacacgtcc tgtacgtgtt tctcttcgat tttattttta tttagtacta 1746841 gtttctcaga ttccaataat ggtaaatgtc caaacaccgc ctccatattc atgtgaatct 1746901 cacctttgtt ttttaaaaaa ttcagcggtt taccatcgtt tcctgtccca aaatcacttt 1746961 ttaaaaaaag acgacttaga aagccgtcct tctcatttct tattttgttg ttcgtttgga 1747021 agctttgctt tcgttatgaa gccggtctgc tgaagtgaca taatacgtat atttcttgtt 1747081 gggatctgcc gtgttatcta agaaggtttg ctgctcatgt gtttttcttt gcgttgccag 1747141 caatgttctc tgctttttcc cttcggctct gtatatcgca taataggctg tttctttcgt 1747201 tttttgattt gatgggtgat ctttaatctg cagaagattg ccgtttttgt cttcggtgac 1747261 tttcgtaagc ttcggttttt ttggggcggt attgtcaagc caaggcattt gcggaaccag 1747321 tgccggcttg ctgtaaagat cggtgctgag actgtctttg atgccaagcg gatttttgtt 1747381 gaggtccttg aggctgaaat gcatgcttcc tttcaccagt tcaagctggc ggttcaaagt 1747441 gatttgccgc acatattcct caggatcgga ccaaggcgga tcaaaattgt tattgatttt 1747501 atatgctgcc tggccaatat ataagtgaac aggcctattt ttgacttcat tgctccacca 1747561 atcagccagc acgtcgtaag ccgctgcgtt aaagccgata ctccaataaa tttgcggagc 1747621 aatataatcg atgtcgcctt cttggatcca atgccttgtg tctgcatata gatcgtcata 1747681 atttctgacg cctgcttttg tattcgatcc ggtcgggtca tctgcggcgt ttctccatac 1747741 tccaaaggga ctgatgccga atttgacata cggttttgca gctttaattg tttggttgat 1747801 ttgtttgaca agctggttca cattgtcccg ccgccagtca tcgatattag aaaaagcgtc 1747861 ttttccgtat tgttcgtact gtgcttgatc aggaaattcc tgtcccgcta ttttataagg 1747921 gtaaaaataa tcatccatat gaacagcatc gatatcataa tgttttacga cttcttcaat 1747981 gcctttgacg ataaaatctc tcgcttctgg aatgcctgga tgataataca gctggtttcc 1748041 ataggcggca acccaatctg gatgttttct tgccgggtga tcctcagaca atttattaag 1748101 atctgtatga ttcattgtaa tacggtaagg attaaaccac gcgtgaaatt ccaaatttcg 1748161 tttatgggtt tcttcaatca taaatgcaag aggatcatag ccggggtcct tcccttggac 1748221 accggttaag tattccgacc aaggcccgta agctgacgga taaaaggcat cagccgtcgg 1748281 tttaatctga acgataacgg cattcattcc cattttttgc acatcgtcca gcagtttgat 1748341 atactcctgt ttttgctctt tcacagataa cccttttttg gacggccaat caatatttaa 1748401 tacggaagca atccatacgg ctctcagctc cctgtcagac tgcgcattgg ccataaacgg 1748461 aacggaaatg acaaacgttc cgatgatcaa gctgacaagg aaacggacaa tcgacttttg 1748521 gcaaaccttc attctgtttc ttctccccca ttacatcact ttcactattc gctattacgg 1748581 tattcccggg ctataaaagg gtgattaaca gaatgtctat ctcactaaat aaacgaaaaa 1748641 agtcctaaag catgttgtga accgctttta ggacttttta tcattcatca tggtttgcag 1748701 actttttaac acatcaataa gttttacgcc gacaccgaca gccgtttcaa ggatcgcttg 1748761 tgctccggca atggctaaaa taaagatcag cggtattgca atacgaggca aaaaaagata 1748821 gccaagtccg atcaagatgg cacaccaaac accggcacac cagtagcaat tgagcatgta 1748881 tccaaagtta gaagccggca cgcttttttc atctacatgc ccgttttgat caacaatcct 1748941 tttctttttc ataaaaggtt ttcggataaa ttctgtgatt ttgtcaaata caatcaaatg 1749001 tgtcagcctg taactggcta gaatcagcat gataaaagtt agaaaagaaa gacggtccat 1749061 tgagaagcct ccaagaaaaa ggatgatgtt atcattccca agtgtccctt atccattctt 1749121 gatacaaaaa gaaagacgga cagagaatgg cctctgtccg ctaatccgag ctcattccct 1749181 ccagttctca taataagagg ataagaaaat gtagaaaaaa gcagaaaaat gacaataaaa 1749241 gaaattatat gactatataa tccatatatg cactatatta acggatattt tttaaagtac 1749301 aataaaaaac attaaatttt tataacattt tttttgaata tagtattatt tctttatttt 1749361 tcgtttcttt ttttatcaaa tttccggata taaagtgata aaagtattgt tttacataag 1749421 gtcttataca ctacttttta atcggactaa ttttcttttg tgcatcattc ttctaattgt 1749481 tggaaggttc gacaaagcgt tattacagac ataaaaaaac ctgttttctc ttggaaaaca 1749541 ggtctcccgc tattattgat ttgccaaaat gacagcgatt tgatcctcaa tatcttttcc 1749601 atcctcttca tcaatcaatc catttagaag aatagagaaa acaagttttt ttccgctctt 1749661 tgtttctgcg taccccgata gagagcttac cgtactgagc gatccggttt ttgctcttac 1749721 ttttccttgt gcaggagtgc ctttcatgcg gtttctcagc gttccgccca ccattctgtc 1749781 aggattcccc gcaacaggta aagaatttag ataagccgag aaccaactct gatcctgaat 1749841 gtcatataac agctgtgaaa gttgatctga ggatacagca tcaatatgtg agattcctga 1749901 tccgtccctt aagacgagtg atttagaatc aacaccaaat tccggaagcg tactgtttaa 1749961 cacttcgagc cccttttccc agctcccttc tccttttttc actttcccca tctcttttac 1750021 gagcacttcg gcatgtccgt tattacttaa tttcatgaac ggcacaaaaa gtttcgataa 1750081 aggcattgag cgatgagaga gcagcacatc tgaagaacta ggtgcttcac ccgtcttgat 1750141 gtcccctttc acagtaatac cttgtttttt tagtgactgc ttaaataaat ctaaggcata 1750201 tccggcaggc tcccagacag aaatccattc ctttgtcttg tttgcgtcaa ccggtacgct 1750261 cccttcaatt gtaatcgtgt ttgttccatg ctctctttcg attgtgaggt ctttctctga 1750321 accggcagca gtcgttttag catcgttctt tatcgttata taatcggttt tcggagagac 1750381 agacacggca ggctcttccc cttctttttg atttggggtg acctcaacaa tcacagtgcc 1750441 tgcatcatag tcttcgtttg gagacgctgt tagagcggag attggcgcgc cataatatgt 1750501 gtattcatcg ctccaaggca tatcaggtga taatcgcatg tcatcatgcc acgtatcatc 1750561 accgatcaga ttgcctttaa ttacttttac gccggaatgt ttcaatatct cagccatttt 1750621 gtcaaaatca gatggtaaaa gtgtcggatc gcctttccct ttcaaataaa ggttaccatt 1750681 cagctttttc cctttcagtg ttccatccgt ccggacctcg gttgtaaaag aatagttctc 1750741 gccaaggaca gaaagtgccg cggccgctgt caaaagcttt agagaagagg caggcctcat 1750801 tcgggtgtct cctgaatgtt catatagaac agcacctgtt tccgcagagc gaacggtgat 1750861 gccggccatt gcgccttcga gggcaggatg atcagctaaa atcttatcga tctgcccgga 1750921 aagtgcatct tgtttttcag cggcaagcgc agcctgatgc atataaggca ccgaagcaac 1750981 gacgaaaagc agtaaaacag caacataaag ctttatgctt tttttcatta atttccccgc 1751041 ctctctgcgc ttcatcattg gctattgatg attcagttca atggtgatac tgcttttagc 1751101 tgtcgtttct tctcccggct ccagcacttg taaaccagtg agtgacgaag gtaaatcaag 1751161 attcactgcg tttgtcaccc atgtgtaagg ctcagggcat aaataccctt gttttccgtc 1751221 cgcattgtat acaacccaat gtttaaactg ttcatctgcc ttataaataa tgctgatatg 1751281 tgcatgctga tgataaatga ctgcctggtt ttctccgccc ctcttctgat aagaagataa 1751341 aaagacatca tccagctgct tgtggcgcaa atccattcct tcatgcaaag cttctttata 1751401 cgggacatcc atcagcttcc cggtcggcag caggcgttca tccaactccc attgctgatc 1751461 tgctgtcagg gagaataacg agctttctgc cggaaatata aatgtagtat gataaccaat 1751521 tccccaagga aacgcttcct ttcctttgtt catgaccgtc gcatgtttaa atagggtatt 1751581 ctccttgatc gtgtatgtca tccgaacgac ggcatgatga ggaaattgct tctgcacatg 1751641 gggaagctca gaaagatcaa tttctgtttc aacaatcact ccttcatcag tttgcttcgt 1751701 ggtcacgaca ttccactttt catggtaaag aaacccgtga agatggttgt gtttatcctt 1751761 ctcgttgata tcaaaatgat acgttctgcc ccggaaactg aatgtaccgt cacttatgcg 1751821 gttaggcggg aacaggattg gaatgccata caatgttggt gtgtcgtgaa aactttctgc 1751881 tgtttccggt tcacgcaaaa gctggacatt tgttgttttg tccacgagag aaatgacgtt 1751941 gctcccccac tcagggacaa caatcatttc tagatgttcg ttgcccgctt tgatggccgg 1752001 cgttcccaaa tacgtgattt tctcaataaa gtttgccatg tttactcaac ctctccttga 1752061 ttcattgcta gtataagaat tcaatgtact gtaccatatt tcctccattt tatattttcc 1752121 cctatcaaat aaaaaaacac cgttcaaact tatgaacggt gtgattcgga ggctattgga 1752181 tgagacgtgt gatttgtttc tttttccaga cgaattgata atacccataa atcaacagca 1752241 agctgacggc aaacgcagct ggataaccaa cccagacgcc gagtatttca agctttgtat 1752301 agtgagaaag gacgaaagcg acaggcacct ctactcccca gattgcaaaa atactgatga 1752361 cggtcggcca taaaactgtt ccgcttgccc gcatcgttgc agaaataatt tgggcatttc 1752421 caaacagcaa atagctccac agtgtaatca tcaaaagacg gtgcgcaatg taaagcgtct 1752481 cttgctcggt taaaaataac gataaaatct gatgtgaaaa aacatagatc agaatgatca 1752541 gtacgccgcc aatgatataa ttcagccaaa tcccaacgcg aatgacctgc tttaagcggt 1752601 caaactcgtt tgctccgatc gattgcgcag cgaaaataga aaccgcaata ccaaggctga 1752661 cggccggcat ctgtacatag ctggccacct ggttgaccac tccgtatgca gctgttgcat 1752721 tagagccgta atgattgacg aatgaaataa ccgctatctc tgataatgag acaagaatca 1752781 tattgatgct tgctgggacc ccaagacgca gcaggagaac cagcagttcc ttatccattt 1752841 tcaaataacg acgcactgtt ttatcaaatt gcagcgggtg ttttcgcttt cgtaaataca 1752901 ccattaacac gagaaaagtc gcaatcgtgg aaatgacagt tgcatatgcc gagccgtata 1752961 tgcccagttt cggaaaacca aacatgccaa ggattaaaac aggcaaaagc gcgatgttga 1753021 tgaccgtgct cacaatcagc gtataaaacg gtgtcttgga atctcctgtt ccgcgcaaaa 1753081 aggtagtata tgcaaaatat aaaaacataa acggcatagc ataaaataaa atacgtgcat 1753141 agttagcgct gacatgaatg acattttcag gtgttcccat taaacgaagg atatccaggg 1753201 tgaaaatact gccgataacg gctaacacaa cgcctaataa aaatgtaaac gtgagtgtcg 1753261 tcccgacaac agcctttagc cgttcctcat ttttcgctcc gtaagcttgt cctatcagaa 1753321 tcgaacttcc tgaaccgatc ccaatcgtaa atgagattaa aagaaaaaat aacgggaaaa 1753381 aggatgatac agctgccact gcatcaacac cgagccatct gcctacagcc atcatcccga 1753441 ctagctggcc gactgattgc agcacattgc tcagcagaag cggcactaaa aagagtgaca 1753501 tcgaccgcca aactgatggt ttgcttttct tttgagttac aagaggttct tgtgatgttt 1753561 ccatattaaa ggactccttt atttgaaatc gtttttaaac atgccctcat tttttgacaa 1753621 aaacaggata tgtaacatgt tattattcat cactgcactt atgaaaccct tcccgattct 1753681 tctaatttta cacatctttt tagcttatga agaataaact agcaagtaat ggcgtatttt 1753741 ttgtgagtaa aagaataaaa aataatttat gcaaaagtat tgtaatctat ccgtaattat 1753801 tgtaacattt gtaacataag agaaagagat tttgaaggag agagcgataa tgaaaaaatg 1753861 tcttctattt ctaacaacca ttgcacttat tctgtcatta agcacaaatg catttgcgaa 1753921 aaatacatca ggcgatttat cacaaaaaca agcattacag ttggcattat ccgctagaga 1753981 acatttttgg aacaccatga gcggccacaa tccgaaggtg aaaaaagcag tttgcccatc 1754041 aggcacattc gagtatcaaa atcttcaata tgtatacatg tgcagtgatc taggcactaa 1754101 agcaaaagcg gtgaattatt taactcctat ttttacaaaa acagcaatcg aaaaaggctt 1754161 taaagattat catttcactg tttcaaaagg aaaacttgct gttccaatcg gtgacggaga 1754221 caatcttttg aattggaaaa aatcaactgc taaactgatc tctaaaaaag gcagcacaat 1754281 cacatacgaa tttactgtcc ctacattaga cggatcccct tctgcaaaac ggaaagtgac 1754341 atttgtgaaa gaaaataaaa aatggaaagt caatcaattt gacgcagtta tataagaaaa 1754401 acgcccggta taagcgggcg ttttttattt ggtttgcata aagaaagaca acaggcgaaa 1754461 agtgcctgtt gtctttttgt gaatataacg ctctaggaga gattcgaact cccgacctgc 1754521 agtttaggaa actgctgcac tatccgctgt gctactagag cttttggtat ttatatagta 1754581 gctctgatga tcaatatttt caagcgattt gtattaaagc cctccaaaaa ccttatatgc 1754641 ggctcttgtc gtatcttcat caataccgat ataccgcatt gtaattgatg gtgatgaatg 1754701 attcagtatt ctctgcagct cggcgatgtc tttcgttcgc tgataaaaat gatagccaaa 1754761 cgttttccgg agtgtatgcg tccctatctc ctcaagtccg cacgctgcag cggcctctct 1754821 taaaattctg taggcctgaa tgcgggaaat cggcttcctg gtccgcactg atttaaaaag 1754881 atattcgttt tccttcatgt ctttcgtata ctcgtatatt tcctgtttca gcgattctaa 1754941 aataagaatc tttcttttct ttttcgtttt gctttcagtc gcccataaat gatctttatt 1755001 ttgaacgtcc ttcacttgca gcggcagaat atcagaaata cggagcgcgc tgttgatgcc 1755061 gaaaataaac agaaaataat cccgcttgtt tttgttaagc aaatactgtt tgacttcttg 1755121 gattttctct agactgcgaa tcggctgtac aatatgcatc aaaaaactcc ttaaaaaccg 1755181 ttatgtaaca ttttgaggtc tatgttacta ttatagctga aaaacgttga atgtcaaagt 1755241 gcggcggcgt ttatgtaaca taatatacat agtgttacat aagcttttaa aaaagcttct 1755301 tccaaccttc accctataaa ataagcttta aagcctctta taaagctttt aacctcttgg 1755361 atacttatcc ccctactaat catcaaaaaa cctcttaaaa tgaaatctga cactcccaat 1755421 tttctggagc ttccgcaaaa atatacaaaa aaagacacaa tttcaaattg tgtcctaatc 1755481 ctcatccttt acatcaatat cttccgggat cggttcattt aatatttcct gcacaagtgc 1755541 tttgtaattc tccagctgtt cgagatgcgt tttgaactgt tccttataaa tcaaaaattg 1755601 ctccccgtca tgaacggctc tgattttccc ttcgagcacc aagcttttaa tataatcctc 1755661 tgaaagattt gtatattctg ctgtttcttc aatcgttaaa tacatatagc agtcccttct 1755721 taatccgtat gctgattcta atatagcaca tggctcatat caatataatc aattctgcac 1755781 agaaaaacgg cattatgcac tatataatat accatttgtc acttgtgaaa acgctgtaat 1755841 ttttttacgc taagattgta acaatacagc ttcatatagg agggagaaca tgaaaagaac 1755901 gtggaacgtc tgtttaacag ctctgcttag tgttctgtta gtcgctggaa gtgtcccttt 1755961 tcacgcggaa gctaaaaaac cgcccaaaag ctacgatgag tacaaacaag tagatgttgg 1756021 aaaagacggc atggttgcga ccgcacatcc tcttgcttct gaaatcggtg ctgatgtgct 1756081 gaaaaaagga ggaaatgcta ttgacgcagc ggttgccatt caatttgcac tcaatgtaac 1756141 agagccgatg atgtcaggta ttggcggcgg cggttttatg atggtgtatg acggaaaaac 1756201 gaaggataca acgataatcg acagccgtga gcgtgctcca gcaggcgcaa ctcctgatat 1756261 gtttctggac gaaaacggca aagcaattcc tttctctgaa cgtgtaacaa aaggtactgc 1756321 cgttggtgtt ccaggcactc tgaaagggct ggaagaagcc ttggataaat ggggaacccg 1756381 ttcgatgaag caattaatta ccccttctat taaactcgct gaaaaaggct ttccgattga 1756441 ttcggtgttg gcagaggcca tttctgatta tcaggaaaag ctttcacgga ctgccgcaaa 1756501 agatgtattt ttaccaaatg gcgaaccgct taaagaagga gataccctta ttcaaaagga 1756561 tttggctaaa acatttaagc ttattcgctc caaaggcact gacgcttttt ataaaggaaa 1756621 attcgccaag acgctttctg acactgtcca ggatttcggc ggatcaatga cagaaaaaga 1756681 tttagaaaat tacgacatta caattgatga accgatttgg ggagattatc aaggctatca 1756741 aatcgctact actcctcctc caagctccgg cggtattttc ttattgcaaa tgctgaaaat 1756801 ccttgatcat tttaaccttt cacaatacga tgtccgctca tgggaaaaat atcagctgct 1756861 tgctgaaacg atgcatttgt catatgccga ccgtgcgtct tacgcaggtg atcccgaatt 1756921 tgtaaatgtt cctctcaaag gcctgcttca ccccgattat attaaagaac gccagcaatt 1756981 aatcaaccta gatcaagtga ataaaaaacc gaaagccggt gacccttgga aataccaaga 1757041 aggatcagca aactataaac aagttgaaca gccgaaagac aaagtagaag gccaaacaac 1757101 ccactttaca gttgctgacc gttggggaaa tgttgtttct tatacaacaa caatcgaaca 1757161 gctattcgga acgggtatta tggtccctga ttacggtgtt attttaaaca atgaattaac 1757221 ggattttgat gcgataccag gcggagctaa cgaagtacag ccaaacaaac ggcctttaag 1757281 cagcatgacc ccgacgattt tatttaagga tgacaagcct gtcctcacgg ttggatctcc 1757341 tggcggggcc acaattattt catccgtttt gcaaaccatt ctctaccaca ttgaatatgg 1757401 tatggaatta aaagcagctg ttgaagagcc gagaatttac acaaacagca tgagctctta 1757461 ccgttacgaa gacggagttc ctaaagatgt cctcagcaag ctaaacggca tgggccacaa 1757521 attcggcaca agtccggtgg atatcggaaa cgtgcaaagt atatcgatcg accatgaaaa 1757581 cggcaccttt aaaggtgtag ctgattcaag cagaaacggc gcggcgatcg gcattaattt 1757641 aaaacgtaaa taaataaaaa actgtactcg cttcaaatga gtacagtttt ttcatgcaga 1757701 tctttaaaat aaaaactgac aaacgtcttt attctgctaa tgcacgtcta tcttcatctt 1757761 ttcatttcgt ttatctcatc aagaaatgtc tgaaacgcac tcgtaataaa aaagtctttc 1757821 ctgtatataa agacgatctc taagtcttga tatgatggtg gcagctgatg aatccataca 1757881 tttgtacgat gctcggagcc gtcaacagcg gactttggga gcagcgccgt acccatcccg 1757941 gcggaaacac cttttataat agcctccaat gtgccaaact ctatgatttt ttgattgtgt 1758001 atgcctgctt cctctagtaa tcttttgacc ctgtcacgat gagaacagcc agccccaaaa 1758061 aagagcatcg gctgctgaag catgtcttct gccgtccctt ctcgtgatga aatcaaaact 1758121 aattcatcat gggagacatg gagttgtcta actgcagcgt gttcaaccgg cccatataca 1758181 aaagcgccat caactttatg atcaagaacc tgttgaatca aatgatgcgt atcagctgtg 1758241 ttcactgata aatccacttc aggaaaacgc ctgaggaagg atgctgcatg ctcaggcaga 1758301 tgcgttaccg ccattgtttc cagtgatccg atccgcaaag gcccttttgg ttgcctgctc 1758361 attcgggtcg atttttcagc ttggtctaac agcgataata cttgatctgc atattgtaaa 1758421 agattttctc ctgcagcagt cagcttcatt ccccgattcg ttcgatgaaa aagcctgata 1758481 ttcaaatctt cctcaaggtt atgcactctg gctgtcacat tcgactgaac ataattcagc 1758541 atttgggctg ctttcgttat gcttccttcg cgagcaacag cctgaaaaat ctttaaatct 1758601 ccgctttcca cgcgctctca cctgcttgct atgatgaaaa gtgatattgg ctatcatatt 1758661 tgttcatttt actcgaagaa aaccgctatg taaaatatgt aaagatatga aaatacaatt 1758721 aatgaggagg cagacagcat gaaagctgta attcacaacg gaaaagccgg tcttctgggg 1758781 ttatcagttc aggacgttcc atcaacaaag cctggatacg gagaggtaaa ggttaaatta 1758841 aaatctgcag gcctgaatca tcgtgacttg tttcttatga aaaacaaatc tgaacaagat 1758901 cctcacatga tactgggttc tgacggcgcg ggtatcatcg aagagattgg tgaaggcgtg 1758961 aaaaatgtta ctgttcagac agaagtagtc attttcccga cattgaactg ggatttgaca 1759021 gaaaatgttc cacctgtacc tgagattctg ggaggtcctt cggacggaac acttgctgaa 1759081 tatgtgatca ttccttcaca aaatgcaatc aaaaaacctg cttatttatc ttgggaagaa 1759141 gcgggcgttt tacctttatc cgctttaact gcatatcggg ctctgtttac aaaggggcaa 1759201 ttaaaaaaag gcgagcatct attgataccc ggcatcggca gcggtgtagc aacctacgct 1759261 ttatttatgg ctaaggcgat tggggcaaca gtaagcgtga cctcccgcag tgaggagaaa 1759321 agaaaaaagg cgctgaaatt aggtgctgat tacgcatttg acagctacag caattgggat 1759381 gagcagttgc agggaaaaaa gatagatgtt gttcttgaca gcataggacc tgccctcttt 1759441 tcggaatact tccgccatgt aaaaccaaat ggccgtattg tcagctttgg ggcaagctca 1759501 ggggataatc tcagttttcc ggtgcgttct ttattctttc ctcaggtcaa tgttttggga 1759561 acctcgatgg gaagcggtga ggaatttcaa gctatgctcg ctttcattga caaacataag 1759621 ctgcggcctg taattgaccg gatatatcct ttagaaaaag catgtgaagc atataaaaga 1759681 atgcaggaag gcagacagtt tggaaacatc gggatcgtaa tggaataaaa aaagaaaccg 1759741 gctggcagcc agaccggttt ctcttatatg ataatcccct ttatttacgg aagaactgaa 1759801 ctccccatca aatatcgatc cacttcacgc gccacttcac ggccttcatt aatcgcccat 1759861 acgattaagc tttgccctct tcttgcatcc cctgcggcga atacaccatc gatatttgtt 1759921 tgataatccc catatgctgc actgattttg ttatttactg aattaacacc gaactgtttc 1759981 aacagcggct gttctgtgcc ttcaaagccg atagcgataa agacaagctg agcaggccat 1760041 actttttccg ttccaggcag ctcgcggaac tcgtattttc catgctcatt tttcactttt 1760101 tccatttgga tggtatgaag ctctttcagc tttccgtttt tatccgcgac catttttgtc 1760161 gtttgaatgg agtattctct cggatctctt ccgaattttg cttctgcttc ctcgtatgca 1760221 tattcaagcg taaagacgtg tggctgttca ggccacatat tgtcattcgt gcgggctggc 1760281 ggaagtttcg ggtgtttgcc gaattggtgc acgcttttgg ctttttgacg cagagcggta 1760341 gccacacagt cagctcctgt atctccgcct ccgattacga tgacatcttt ccctttggca 1760401 tcaatgaatt gcttgtcttt aaaattagaa tctaaatagc tttttgttgc aagtgtgagg 1760461 tagtccattg cgtaatggac tccttttgag tcgcgtcctt cgattaagag gtcccgctgt 1760521 ttttgagcgc ctgtgcataa gatcacagca tcaaattgct cctttagctc atcagctgta 1760581 atgtcaacac cgatttctgt gttcgtgaca aaatcaattc cctcttgcgt cagcaattta 1760641 attcggcgtt ctacaatgcc cttctcaagc ttcatgtttg gaatgccgta tgttaaaagg 1760701 ccgcccgctc tgtctgctcg ttcaaaaaca gtgacggaat gtcccgcttg attcagctgg 1760761 tcagcactcg ccagtccggc tgggcctgac ccgacgatgg ccactttttt gcctgttcgt 1760821 ttttttggaa ttctaggttg aatccagccg ttctcaaatc ctttatcgat aatggtccgc 1760881 tcgatgtttt taattgatac ggccggatct gaaatcgcta aagtgcatga tccttcacaa 1760941 ggagcggggc atacccgccc tgtgaattca ggaaagttgt ttgttttcaa cagacgttcc 1761001 aatgcttcct tccatctgcc ccggtagaca agatcattcc attcaggaat taagttgtaa 1761061 atcggacagc cggatgtaaa tccgttaatg tccgcaccga tctggcaaaa cggtgtaccg 1761121 caatccatac accgcgcccc ttgccgtttc gatgcttctt ctgaaaaagg agcagaatat 1761181 tctttccaat cctttaagcg agtgagaggg tcccgctccg caggtttttc tcgtttgatc 1761241 tccataaatc cagttggttt ccccatgttc ctctcccctt ccttactgta ctaccgcttg 1761301 tttttgtccc gatgctgctg tattctgctt tggcttcgtg ttggcctcaa aagcgaacat 1761361 gatggcttct tcatctgata aacctgcagc tttttgctct tcgatgcttg cgagcatttg 1761421 tttatagttt ttcggaatga ctttgacgaa ttttttcaca ctgtcttccc attgatctag 1761481 cagatcttct gctttttggc tgtttgtata cgcagtatgt ctttcaagca ttgctttgat 1761541 ttgctggatt tctttctcat cctctaatga ttcaaataaa atcatctcaa ggttgcattt 1761601 gcgtttaaac gctttgacat cttcggtcag tacataagcg attccgccgg acatacctgc 1761661 cgcaaagttt ttgcctacat caccgagaac gacaacgctg ccgccagtca tgtattcaca 1761721 gccgtggtcg ccgatgcctt ctacaactac gttcacaccg ctgtttcgaa cggcaaagcg 1761781 ttcaccagca cgcccgttaa tatatgcttc tccgcttgtc gcaccgtaaa aagccacgtt 1761841 gccgataatg acattgtcat ccgaagcaga gttgaatcct tctgatgact tgacgatgat 1761901 ttttccgcca gaaagccctt ttccgacgta atcatttgag tctccgtcca aataaagcgt 1761961 catcccttta ggaacgaaag ctccaaagct ttggccggct gatccggtaa agtgcagctt 1762021 gattgtatct tcaggaagac cttcttctcc gtaacgcttt gagatttcac tgccggttat 1762081 cgttccggct acacgatttg tattattgat ttcaatcgaa atatcagctt cttttccaga 1762141 ttcgatggct tcttgtacgg ccgggagaat tgttgtaata tcaagtgatt gatcaatttt 1762201 atgattttgc ggcgattgga acgtccgcac cccttcaggc tgataaagaa gggtagacaa 1762261 atcaagctgg cttgctttcc agtgctcctt tgcccgttca cttgcatgaa gtacatcagt 1762321 gcggccgatc atttcatcaa atgtcttgaa gcctaacgca gccatgtact cacgaacttc 1762381 ttcggcaatg aacagcatat agttcacaat atggtcagga tctcccatga actttttgcg 1762441 aagctctgga ttttgtgtcg ctacaccgac agggcatgta tccaaatggc aggcacgcat 1762501 catgacacag ccgagtacaa ctaacggagc cgttgcgaaa ccaaattctt cggcgccgag 1762561 caaggcagcc atcacaacgt cgcggcccgt catgagcttt ccatctgttt ctaatacaac 1762621 acggtcacga agtccgttca gcattagtgt ttgatgtgct tctgcaaggc caagctccca 1762681 cggaagccct gtatgtttaa tactggtttt cggagaagcg cctgtacctc cgtcatagcc 1762741 gctgatcaca atgacatctg cagtcgcttt ggcaacacct gcagcgattg ttcctacacc 1762801 tgcttttgac accagcttta cgctgattct tgcgtcacgg ttggcatttt tcaaatcgtg 1762861 gatcagctgg gctaaatcct caatcgaata aatgtcatgg tgtggcggag gtgagattaa 1762921 tccgacacct ggcgttgacc cacggacatc ggcaacccat ggatatacct tgttgccagg 1762981 aagctgcccg ccttcacccg gcttagcacc ttgagccatt ttaatctgca gctcatcagc 1763041 attgacgagg taatggcttt tgacaccaaa ccgtccggat gcaatttgtt tgatcgcact 1763101 tcttctatca tcgccgttct catctggaac aaagcgtttg ggatcttctc cgccttcacc 1763161 gctgttgctt tttcctccaa gacggttcat tgcgattgct aaagcttcgt gcgcttcctt 1763221 actcaaggac ccgaatgaca tcgcacccgt tttaaaacgt ttgacaatcg attcagcgga 1763281 ttcaacctcc tccaacttca aaggcttgcg gtttccgtca aatgcgaaca agttccgcaa 1763341 aaatccgatg cgttcttcat cagccgcttt tgtatactgt ttaaacagat tgtaatcatt 1763401 tctgcggcac gcccattgca aagtatgaat cgttttcgga ttaaacgcat gatgctctcc 1763461 gccatttctc cattggaagt cacttcccgg ttcaagcgtt ttgctgtaat catcctgata 1763521 cgcttcccgg tggcggcgct gtgcctcttc tgcaattgtt tgtaaatcga tgccgcctag 1763581 ctgtgatgca gtacctgaga aatagcggtc gatcacatcg cggctgattc ctaccgcctc 1763641 aaagatttgt gcgcctctgt agctttgcac agttgaaatt cccatcttgg acatcacttt 1763701 tacgacgccc tcagtaatgc tttttccata tttgctaacc gcttcttcat agctgatatc 1763761 caaacggcct tcatcaattt cctgcttgta ggtcgcataa gcgagataag ggttaatcgc 1763821 atctgcgcca taaccgatta acgctgcaaa gtgatgcact tcacgtgctt ctcccgattc 1763881 cacaataatg ctgaccttcg tacgcagccc tttgcggatt aagtgctggt gcagtgcgct 1763941 tactgccaga agcggcggaa ttggtgtcag tcgttcgttc atctttttgt ctgataaaat 1764001 taacaaactt acgccttggc tgatggcttt ctctgcctgt gtgaacatgt cctttaaacc 1764061 gcgttcaaga tcctctgaaa acagcacatc aattttttgg ctttttaaat caggatgaac 1764121 aatcgttttc aatgcgtaaa actgttcatt ggataaaaca ggtgtataca gtttaatccg 1764181 gcgaacattt cgttcacttg gatgaagaag atcgccttcc gcaccgagcc aagtcatcgt 1764241 tgaagtgaca agctgctcac gaatcgcgtc gattggcggg ttcgttactt gtgcaaacag 1764301 ctgtttaaag tagttaaaca gcgattgcgc tcggtcagaa agtacagcaa gcggagcgtc 1764361 attccccatt gaaccaaggg gatctttgcc ttctttaata acaggaatta gatacttttg 1764421 gatatcctca tatgtgtatc cgaatgcctt ctggcgagta agaagatcac taaattgttc 1764481 ttcttctctt gactccggat caggatttac ttgtacaagc tcttcttcaa gccatttttg 1764541 gtacggatac tcagttgcaa tttgtgtttt gacttcctca tcggagataa tacggccttc 1764601 ttccaggtcg attaaaagca ttttcccagg ctcaaggcgg tttttatata aaacgttctc 1764661 ctgttcaact tcaataacgc ctacttcaga tgagaaaata atataatcat cttttgtgac 1764721 ataataacgg gccggacgga gaccgttccg gtcaaggatc gccccgattt gtttaccgtc 1764781 agtaaatgaa atagctgtcg gtccgtccca aggctccatc agggagctat ggtactcgta 1764841 gaacgccctt ttttccttgg acatatgcgt attttccgtc caaggctctg gaatgagcat 1764901 cattgccgta tgtgccggtt tgcgtccagc catcacaaaa aactcaaatg cgttatccaa 1764961 aatggaagag tcactgccat cagcattgag aatcggcaaa atcttgttta agtcctcacc 1765021 gaagctttca gaaacaaatt gctgctcacg tgctctcatc cagttgatat ttccgcgaag 1765081 ggtgttaatt tcaccgttgt gaaccaaata gcggttagga tgcgctcttt cccatgtagg 1765141 gaatgtattg gtactgaagc gtgaatgaac aagcgcaaaa gcagaaacga atgcttcgtc 1765201 ttgcagatca gaataaaatg catcaacctg ttcaggtgtt aaaaggcctt tgtaaacaat 1765261 ggtctggctt gaaagactgg caaaataaaa atcaagacct tccgttactc cccaattttc 1765321 agcctgttta cgaatgacat acaattttcg ttcaaaagat aaattgtcct ttagatcaga 1765381 acttgcgccg ataaatacct gacggacaaa cggacagctt ttttgcgcca ctgttccgat 1765441 ttttccgaca tttacaggta cagttctcca tccaagaacg acttggcctt cttgttcaat 1765501 tagtgcattg atttgctttt caattttttt tctttcatct tccttctgtg agaaaaagac 1765561 cattcctacc ccgtaacgtt ctttttctgg cagattgatg tttttgcact cttttctaaa 1765621 gaaagcatca gggatttgaa ccagtaagcc ggctccgtct cctgtatccg gatcactgcc 1765681 ttgccctcct ctatggtcta gctggcaaag catcttaagt ccttgtttga caatgtcgtg 1765741 agtctgcttg ccctttaagt gtgcatatag gccgattccg catgcatcat gttcaaattc 1765801 aggacggtag agaccttgag cttttggcat ttgattgtac gtcataattc ctctcccccg 1765861 atcaatttcc gataataccg gtcataaaat ctaacaactc tataatcatt gtaggttttc 1765921 aaaacgatat aaacaatata taatttagat caaaagaatc tcaaaatgag atagatggat 1765981 gtgagacaaa catggagctg cgccaactgc gttattttat ggaggtggct gaaagagaac 1766041 acgtttcaga agccgctgat catttgcatg tggcccaatc agcaatcagc agacaaattg 1766101 ccaatcttga agaagaatta aatgtgacct tatttgagcg tgaagggaga aatatcaaac 1766161 tcacgccaat cggaaaagaa tttttaattc atgtgaaaac ggcgatgaaa gccattgatt 1766221 atgcgaaaga gcaaattgat gagtatcttg acccgcatcg cggaacggta aagatcggct 1766281 ttcctacaag cctcgccagc cagcttttgc cgactgtcat ttcagcgttt aaagaagaat 1766341 atccgcacgt cgaatttttg ctgcgccaag gctcctataa gtttctgatt gaagctgtca 1766401 gaaaccgcga tattgatctg gccttattag ggccggtgcc gacgaatttc tctgacataa 1766461 cgggaaaaat attatttact gaaaaaattt acgcgcttgt tccattaaat catccgcttg 1766521 ctaaacaaaa aacggttcat ttaatcgatt tgcgcaacga ccaatttgta ttgttcccgg 1766581 aaggatttgt acttagagag atggcaatcg atacttgcaa acaagcaggc tttgctcctc 1766641 tcgtttccac ggagggtgag gatttggatg cgatcaaagg gttagtgtcc gcaggaatgg 1766701 gcgttaccct tctgcctgaa agtacttttg ctgaaacaac acctcgtttt actgtgaaaa 1766761 ttccaattga gttccctcaa gtaaaacgga ctgtcggaat cattaaaccg aaaaatagag 1766821 agcttgcgcc ttccgcgaat gatttttatg agtttgtcat tcaatttttc tctaagctgg 1766881 agcagtatca ataaaaaaaa tgaacccgag cttctatata gaagcttcgg gtttttttct 1766941 gcaaattaat ttacaggtaa agaaaaatcc acatggcaaa caaatgcttc ttgatcaatt 1767001 agagctctat ttgtcagttc ctttttcttt tccggttctt gaagctgtac agaagagtaa 1767061 ttgacgattc caaggccgat ttccgtccct tttgaatcca tcagccgaac aactgaaccg 1767121 cttttgaatt tccctttaat cttctgtaca ccgtctaggt ataaactcga ttgtccgttt 1767181 gttatttttc gtgaacaatc atctgataaa atcatttcac cttccggacc ggaattaaaa 1767241 gcgatccatt gctccttttg attcaacgga agcgttcctt ctgcttcaaa ataggtgcct 1767301 tccgcctgtt catgaacggc gtggtataaa atatcgccag catctgcctg acctaggaaa 1767361 cctttaatgc cagacgccat tacgatttta aacgcatcaa gcttagagcg catgccgccg 1767421 gtgccaacga tgcttccagt gtcacctgcg catgcttcga tgtcaggtgt tatttcactc 1767481 acccgctgta tctttttcgc ttctggattt gtgcgcggat tgccgtcata taatccgtct 1767541 atatctgata aaatcacaag catatctgca tcaatcaatc ctgcgacttt tgctgcgagc 1767601 gtatcattgt cgccaaactt gagccgattg acggtaactg tgtcattttc gtttatgatc 1767661 gggatgatgc cgcgctcgag cagtacattc attgtattcc tgacattgtt gtatcgatat 1767721 tcatcagaaa aatcgcttct cgtaattaaa atttgggatg cgacatagcc gtgtgccaaa 1767781 aacagctttg aataagcctc cattagcaat ccctggccga ttgaagctga tgcttgtttt 1767841 tctggaagct tctcgggcct ttggataaat ccgagcttcc gatatcccgc cgccactgcg 1767901 cctgaggaaa ccaaaatcac ttcataaccg gcgtctttga gtttgacgac ctggtcgacc 1767961 aacgcttcta attttcgaat gctgatttct ccatgaaggc ttgttaatga actgcttcca 1768021 atcttcacaa cgactctttt catgcttgta tcaggcgtca ctttatcact cctgatagcg 1768081 gcgctgcagt tttttcgata tcttcgctga tttcctttga acgcttagcc gcatgcttta 1768141 ttgcttgaga aatcgcttct ccgccgccgc tctttttcaa ggcttgcagc cccgctgctg 1768201 tcgttccgtt cggtgacgtg atattatctc ttaagatctc aggatgttct cctgtttcca 1768261 tgagcatttt tgcggcacct aaaagtgtct gtgcgccgat gcttcgagat aactgtttat 1768321 cgaggcccgc ttcctcgcct gtcttttcaa tgaattccat taaataataa aaatacgcgg 1768381 gtccgctgcc tgcaattccg gtgaatatat ccatttgatt ttcttggatt gtatagactt 1768441 cgcccatgca tccgagcaat gcttcggcca gcttcttcag gtcttccgac acatatttgc 1768501 caagggcaat agctgttgca gaagcgccaa tcatactgga agtgttgggc atcactctga 1768561 caaccggctg ttcattaagc aatgattgtt caataaaaga ggtagttatg ccggcaagga 1768621 ccgacaatat taattgatgg ggttgaatac gtgattttag tgatgacaga gcgttttcgg 1768681 cgtcttttgg cttcattgcc aaaatgagca catccatgtc ttcaatacat agttggttcg 1768741 gcaaggcgcc tttaatgcca tattgaagtt caagttcagt taatcgctct gtattgctgc 1768801 ggtttgtaac gcagatgttt tgtttcggga ttttgttggc tcgaacgata cctgatatca 1768861 ttccttccgc catagatcct gctcctataa aggctacttt cttttgatca aagatcggta 1768921 acatctcctt tgttcgcttt tttgttcgca ttttcacacg tttaaaatgt taccacgtga 1768981 ggaaatgatg tcaagtttga aggccattat tgatttgtat tgtttctttt cgacaaatat 1769041 gtataatgaa aagcagaaaa cacccggttc acactgctgc gccgggtgtt tgtttctatt 1769101 aaaaattatc tgagagagct ttttcaatca gttttttaca gcgatccagc tctaccttca 1769161 gctgtttttt atatagcttg gcagcttcgt aatctttaaa ttgatagagg acgacttcct 1769221 ggagcttagc cccttctttt tttactttaa tttgttttag tatcccgtca tcaagaagct 1769281 catgcaaaga ccggtatact tctgtatgat ttggtttaaa accaatctct ttaaattcag 1769341 accgaagtac ttcaagcagc tttaacccat agagtctctc ttgctctgtc atcgttatca 1769401 tataaagctt caaaaatgcg cgctgtttca ctaaaaagcc tgttgaactc cttttttctt 1769461 ctttcatcat atgcactcct tcttctgtca ctgacaacac tatgtactaa atattcaatt 1769521 ttcttttatt gttttccttc tttatattaa agactgatag tccagttatt tcatgtttac 1769581 tgattatagg tgtagcggaa aaaataaatt tcgactgaac atttggtaca tagttttctt 1769641 agttctatta tagcctgcat ttactgctat cttcaattta aacgattgcc agggtttaca 1769701 tatctcattt taccggtacg gatttcattc aaataaaaaa acctgtcgaa agacaggttt 1769761 tcatttttaa ggatttgttg accataatcc cgctgttttg atgaaaatac gaggatctaa 1769821 tttcagttgt gccaccatgt actcagcaag atcctcaggc tgcataactt tttcaggatt 1769881 accgtctgtt aagttcaatt cgatagacat atcactagcg acagtgctcg gcgttaacgc 1769941 gctgactctg atattatgtt ttctcacttc ttgcataaga gactctgtta acccgagaac 1770001 ggcaaattta gaagcgctgt aagcacttgt tacagcagct cctctttggc ccgctgtaga 1770061 tgaaatatta atgatgtctc cggctttgcg ttcgatcatt tccggaagca ccgcgcgagt 1770121 gacatggtac acacccatta ggttgacttg aataatattt tcccactcat cagctgacag 1770181 atctaagaaa ccgccaaatt tgctgatgcc ggcattatta atgaggatat cgatatcacc 1770241 gagctgttcc ttcacttgag ctacagcttg gttaacctga tcggcatctt ttacatctgc 1770301 agcagcaaat gcagctttta caccaagcgc tttgacttct tcagccactt tttctacatt 1770361 agcggaagtc cggccaatta acccgatatt cacgccttct ttggcaagcg ccagagcagt 1770421 agcgcggcca attcctctgc ctccgcctgt gattagtgca gttttatgtt gtaaactttg 1770481 caattgaagc accctttctt tgtttacata tgtacgatat cacattataa gtacaataca 1770541 tccaatacgc aaatcaaacg aactgtgtaa atatcatttc ttctgattaa aaaaacggat 1770601 acagggtaat gacataagaa aaggagtgaa catatgatta tagtttatat cagtcttgca 1770661 gtattagcag tttctattat cttcttagga gttaccgtga tccaaaacaa gaaaaaaata 1770721 gaccccgcac taaaggagct ttcctctgtt acgcaggcta tgcaaaaaca aatcgaagga 1770781 ttaaaaacag aaacagagct gctgacgcaa aaacaaaaga agattcagca ggatgtccaa 1770841 ataaaaaaat acacgcttca gcagaccgca gctgaagtga aagaagttcc ccaagcagtc 1770901 aaagaggtgt ggcaggcagg acattttaat agcagataag gatgaatgag atcccgttgt 1770961 tacgatcaga atggacaaat gggatctcat ttttcgagga ggcttacaca tgattataaa 1771021 ccgcagctgc ttaaaagagt tcgcagaaaa agtacatttt cttccctctt cacttacaaa 1771081 gtccgattta cttactgatc catttcgtct ccatcaagaa aacgaacttg gcatctacta 1771141 ttcacctcat aatgaattta tcaatcggga tgcctcgctt gtgattgccg ggatcacgcc 1771201 tggtttttcc cagatgaaga cagcgtacga aacagccgcc gaaagcctgc tgcaaggcgg 1771261 gactcttgag caaatggcag tagacacaaa aatagcagcg ggtttctccg gatcgatgag 1771321 acataacctt attaccatgc tggatttatg cgggctgccg caagcttttg gcattcaaag 1771381 cgccgcaaag ctttttggag aattacggca tatgctccat acaacttccg ttattaaata 1771441 tcctgtcttt atccagcaaa aaaactatac cggatacaaa ccggctatca ctcattctcc 1771501 tatcctaagc acttatgctt ttgggcactt ccctgcagag cttaaccatg tgacgggacc 1771561 agctcttctc attccgttag gaaaagcggc cgaaacagtg tgtgaaacat tgatcagaca 1771621 gcacagcctc cagaatttga tttgccttaa cggctttccc catccatcag gcgcgaacgg 1771681 ccatcgtttg aaacaattca gcaaaaacaa agagcaacta gaaagacaaa ttcgttcctt 1771741 tgctgcattg gttgatttcg ctatagaaaa gaggaaataa aagggatatg ataaacaaaa 1771801 acacaaacgt ggggagtggt tgaatgtttc ctatattaga aacggatcgg cttatactta 1771861 ggcaaatcac agatcaggat gcggaagcca tttttgcttg tttctcaaac gatgaggtga 1771921 cacgctatta tgggcttgaa aacatggaat ctatagaaca ggccatttca atgattcaaa 1771981 cgtttgctgc cctctatcaa gaaaaacgcg gtatacggtg gggaattgaa agacgggaca 1772041 ctaaagaact gatcggaaca attggctttc acgctctggc ccaaaagcat aggcgcgcgg 1772101 aaatcggtta tgaaatcatc ccggagcatt ggcgaaacgg atttgcatca gaagtcattt 1772161 caaaggtcgt atcttacgga ttttctgccc ttggactgtc gcgtattggc gcagttgtat 1772221 ttaccgataa tgaagcatca aatcgtctgc ttctaaaaat ggggtttcaa aaagaaggcg 1772281 ttttaagaca gtacatgtat caaaatggga ctccatatga tacaaatgtg tactctattg 1772341 tgaaaccaag agaatgacgg tattctcttg gtctgtgcca catccctttt cctttaaaaa 1772401 gataaaaagc gcccctcaaa cagggcgctt tctaattaag atgcatattg aggagatgtt 1772461 tcctccttaa ctgctttttc ctcaggtata tgaatacatt ttgtcaagac cgcacttgca 1772521 aggtaaaggg ccgcaaagat ccagacgaca ccttgcgcgc cgacgagacc gatgaacagc 1772581 caagcgagtg cagggccgac aaacgctgat aaacctgcag ctaaattcaa tacagacatg 1772641 gctgcccctt tatcttttcc tgccaccgtc ggcacaattg caccaatcgg cacatagcct 1772701 gccagcaaac cgccccaaat aaagccgatc acgctgacaa ccgctaaact tccgccggag 1772761 aaaacaggtg cgtagtataa taagacggtg aaaatgccgc agccgactcc gccgaaccaa 1772821 ataacagtat ttttccagcc gaatttatcg ccgacaatac cgaagataag gttaaacaca 1772881 atgttcccca ggaaaatcgt tccccaaatt tgcagccaca cattggttga aattccatgc 1772941 tgggccatgt gcatcggcaa aaagactgga aaaccatatg taccaatgct gttgatgatt 1773001 ctgatgattc cgcctgtaag cacgcgcgga tttgtaaata gaatcgtaac cccttttaaa 1773061 agctcctcgg ctgtttctga tctttttctt ttcttctttt caaaacggtc tttattgata 1773121 aacaatgcaa agaatgcacc gagacatacc cagaaaatag agctccaaag cgtattcaaa 1773181 taaccgaacg ctttgatcgc gtagcttgag taccaagcgc cgaacacaaa catgccgagg 1773241 caatatgcaa tccaaaacca gccgacagca gtgctcagtt tgctttgcgg tgttctgtaa 1773301 atgacccatg tcaagaaaga ataagcaaaa agcgggtaac ctaacccttt tacgaagtaa 1773361 gtcacataca tcactggcag gttcagctgt tcaaatccaa atacgataaa agcagctgta 1773421 ccgatcacat aaaacaacag ccccataaac atcgttcgtt ttgcgccaaa tgcttcgaga 1773481 catacacccg aaaaccagga agctatggca agcgcaattc cgtatatact aaaaatggaa 1773541 gcggactgct gaacggtgag cccgttttcg atcaaaaaag gactgagcca gccttgttca 1773601 aggccatctc ccatcataaa caaaacaacc cctaaaaatc cccaggcaag ccgcttcggt 1773661 attcctattt tatccaacat atctgtctcc tccttagatg ctattattca ttaccgtatt 1773721 accttattaa agttgaaaat taaatgattc ctcaaaacag cagaaattcc gtcttaaatt 1773781 aatactttgc tttctgatcc tgaaaaaaag cgctgtgttt gcttccattc ctcatataaa 1773841 gccaattcta tctgacagtc cttcggttcg atcacccgga catttgctga catctcctcc 1773901 gttaattgaa aggtttcatt gcaaatgact gcagcaccga cgacagatgc ctgatgatat 1773961 ccctcttgga catagacctt tttttgaaga agatccgcga tatattgagt gagcgctttg 1774021 ctttggaatc cccctccgca cacccaaaca taatcacgtt caaacggagt aacctctgtt 1774081 aaaatgtcaa agttccattt gattgaaaat gcgatctctt ctagcgctgc acgtacaaaa 1774141 tgtgccctct ttaaatgtgc tgacagcggg gcatcaaaaa gaaaaccgcc tctcgttaac 1774201 gcattctttt cagccgataa ataagagccg agagccgcta cacatgcatg gtcttctttt 1774261 gcaagtgcag aaatctcctc ctccattact tcgtacgttt cattcggata aaaaatctgt 1774321 tttaattttt gataattcaa gccggtaatt cccggattcg tttccacaag ccaatgccct 1774381 tgatccgtat gacagttcaa ccaggcttta tgttttgtgt cgccatgatc ctcagtaatt 1774441 ttggttattg gcgttgttgt ccctgataca atgacaatgt cctcaagtcc agctccggtg 1774501 cttttgacag ccagctgtgt atccccgccc cctgctataa ccttagcatt tattgaaagg 1774561 cctaattcgg atgcatattc atttgctatc gttccaattg ctgttcccgc tcttacaaga 1774621 ggcggaagga tagatggaga aaagccgaaa atgtcgcaca tctcttctga ccaagtgttt 1774681 tgcttcacat caaatagcag ggtttctgtt gcctgtgatg gttcatatgt taatattccg 1774741 ctcagttggt acgtcaccca atcactgatg cttgtaaagc ttgcagtctt ttcccataaa 1774801 gagggctggc gctgttttaa tccataaagc ttgagcgcag aaaaaagtgc agttggcagg 1774861 cggcctgtgc tgctgtatat ctcttcccaa tcgggaatgc ccgcctccca ctctcggccg 1774921 cgattatcga tgttcggcag cccgagaaaa ggattgccgt tttgatcaat caaaacaatc 1774981 ccctgtcttt ggctcgtcga tgtcaaacca atgatgtcaa tatcacacga acgggatagc 1775041 gcacgttttg ccaaattcat cacctgcttc cacagcacct gaggagaaaa ataacggctg 1775101 tccgggtaaa gcgtctctgt ggaatactcg atgtcctccc gttcaactgt tagaacactg 1775161 ccagttacac tcacgaccgc taccctcgca ttgcctgtgc caatatcaaa aacgagatag 1775221 cctttttgtt ttttcattct gttagcctcc tttcttatcc ccctgttttc agtgcgtcct 1775281 tgttatacat tgtctgaata ttaagagttt tttcaccctt ccactttttg agggctttat 1775341 tcagtatcgt cacgtgatga tcctccactt caaatgttgc tccagcgaga tgcggtgttg 1775401 ccagaacatt aggcaatgaa atcaattcat aatctgattc ctctggaggt tcatgataaa 1775461 aaacgtctag tatcgcaccg ctgattttat gttcttttaa tacaaataaa agatcttcac 1775521 ggtttacaac aactgctctt gaagtattaa cgaaaatcgc actctctttc atcagatcaa 1775581 aatattgccg atctatcagt ccgagtgttt cctcagtgcg aggcagatgg acagaaacga 1775641 tatcgctgtc tgaaaacacc gttttaagag atgctttttc atacaacgga tgatcgtctt 1775701 gaatgtatgg atcgtaatat tttatcttac agtcaaacgc agtcagcagt tttgcaatcc 1775761 tttgcccgac tgcgccgaac ccaatcatgc caaccgtttt tcctgttagc tcatttcctt 1775821 taaatttgac ataagcctgc aggtaatcac tgtcccactc tccatccttc agccactgat 1775881 tcgaggcgct ggtatggcgc agaaaggaaa tcacatttcc aataaacatt tcggcaacgg 1775941 cttgtgcatt ccgccctggt gtataaaaaa caggtatgcc cctttttgag gcagctgcca 1776001 catccacatt tgagggcatt cccctgcaaa caccgacaaa tgaaagttcg ggaacagaag 1776061 caaatacgct gtctgttacc tgatcaagtt cagtaatcaa gcctgtcgca tttgttgctt 1776121 ttagcagctg aatgagttca tcctcccgat atgccctacc ttgttccttc caagattgat 1776181 aagcaactga gccaaacaag ttttcaagct cttttcgtcc ttcttcgttg tacggtgctg 1776241 taaccaaaac cgtcatgctg caaaacatcc ttttcatcgt atttttcata aaaaaaatct 1776301 ctttccgaag atggaaagag attcatatat aggcgcgctc tgttacaggc agacgccggt 1776361 ataaaccttg ctttcctatc tttcaagcta gcgcttgctg gaattggcac aataatgttg 1776421 ccgaggtttc atagggccag tccctccacc tctctggata gaaaatattg agtatgtaat 1776481 tttcagaatg aagaatacgt ttatcataaa gaagactcag attgatgtca atctcttttt 1776541 ttcagaattg acgttatcat cggaaatgtt ataattctta caaaatatct aactagagag 1776601 aggaactggg ccatgagatc ttttgccaca caacaaaacg gcattttcaa atccgtttgc 1776661 tcgctggact gcccggatca gtgcggattg ttaatacata aaaaagacgg gaaaatcgta 1776721 aaagtgcaag gagaccctga tcatcctgtc acagctggaa acatatgcaa caaagtccgg 1776781 aatatgacgg agcgcatcta tgatgaaaag cggctgacta caccgctcaa acgaacaggt 1776841 gcgaaaggcc aagcgatatt tgaaccgatt tcctggaaag aggcaatcga tacgatcacc 1776901 tcccgctgga aacagctgat tgatgaagag ggagctgaaa gcatacttcc ttacagcttt 1776961 tacggaaata tggggaaatt gacagctgaa ggaatggacc gccgcttttt ttaccgcatg 1777021 gggtcaagcc agcttgaacg gacgatttgc agcaaagcgg gatctgaagg ctataaatat 1777081 acaatgggca taagcgcggg aatcgatcct gaggaaaccg ttcatacaaa actatttatt 1777141 ttttggggaa tcaacgcggt cagcacaaat atgcaccaaa ttacgatcgc ccaaaaagcg 1777201 cgaaaaaaag gtgccaaaat tgtcgtgatc gatgtgcata aaaatcaaac aggacgtctt 1777261 gcagattggt ttatcccaat aaaaccggga accgacagtg cacttgctct tggcatcatg 1777321 cacattttat ttaaagaaaa ccttcatgat gaagcatttc tgtccgagta cacggttggc 1777381 tatgaagagc tccgtgaaca cgtgaaacaa tatgatcctg aaaaggtatc gacgatcacc 1777441 ggtgtcagta ccgaagatat ttaccgactg gcaaaaatgt acggggaaac ctccccttct 1777501 tttatcagaa tcggaaacgg accccagcat cacgataacg gggggatgat tgtaaggacg 1777561 attgcctgtc ttccggcgat caccggccaa tggctgcaca cagggggcgg cgcaattaag 1777621 cataacagcg gaattttaga atataacaca aatgccttgc agcggcccga cttattgaaa 1777681 gggcgcaccc cgaggtcgtt taatatgaat cagcttggca gggtgctttt ggaaacagac 1777741 ccgccgattc gctctctatt tatttacgga acgaaccctg ccgtcgtcgc gcccgaagca 1777801 aacaaagtca gacagggctt gctgcgggaa gacttgttta ctgtggttca tgatttgttt 1777861 ttaacggaaa cggctgcata tgcggacatt gtactgcctg caacatccgc ttttgaaaat 1777921 actgattttt acacctccta ctggcaccat tacattcagc ttcagcagcc ggtgattgag 1777981 agatatgggg aaagcaagtc taacactgag gttttccgat tactggctga agccatggga 1778041 ttcacagacc aggagcttaa agattcagat gaagtattaa tccgccaggc gcttgaccat 1778101 ccagataatc cgcatttggc agagattgat tacgattcac ttactaagca ttcatttatg 1778161 aaagcgaaac gtgaaaagcc gctgtttccg ggcgaacttc caacgccaag cggaaaaata 1778221 gaattatatt cagaaaaaat gaaacaagac ggcttccctg ctttaccgac atatacacct 1778281 cttgtaaccg ataatgaaca tccgtttatg tatgttccgg ggccaaacca taatttctta 1778341 aactcaacat tttccaataa tgaaaaacac atcaagcttg aaaagacgcc aaagctcttt 1778401 atcaacacaa aagatgctga aaaacacgga atcgttgatg gggcacctgt acgaatttgg 1778461 aacagccggg gagaatgcga gctgaccgct gcagttggag aacaagtgct gccaggtgtc 1778521 gttgtcagcc aaggattatg ggcggatgaa caaggaaaaa aacagcttgt aaacgcgcta 1778581 accccagatc gcttgtccga tatgggcggc ggcgccacct ttttttcagg ccgtgtacag 1778641 attgaaaagg tttgaaaaat aatgaaaccc ggagtatgcc aagcccgtat aacataacat 1778701 cgacataatg gaggcataca catggacgtt tttttaggaa ttggtattgc tttggctgga 1778761 tattttatcg gtgaaggctt aaagcagagg aaccaaacca aaggtaatga acaaaatgat 1778821 atcttcctaa taaaagaacg ggatatttac ttttacattg gacttttttt aggaataaca 1778881 acgactgaag caaaacagtt agctggagac atggcagacc tgccttacat cgaaataaac 1778941 ggaaaaaaat atgtccagaa acatatgtta aaagattgga cattcacatt agttgaaaaa 1779001 catcagggtg aataaaacaa atctgaggag agcgagattc attgtcacgc tctcctctgt 1779061 ttagctgtat ggatcctgcc accaaaactt tgtgctataa gcgctgataa aacgataaac 1779121 caccatctat gttctttcct caaacaactc aagatgcccg ttccacaaca atagttttta 1779181 tattcctttg atgacgtgat gttcttgatg aacgtatgta tcgtaaaaca cttagaaaac 1779241 ctattcggtt tgaatgtgtg ctctcattat gcccccatac tgcgccttta tccgcggagg 1779301 atttttttaa aaaaatatga aacctaaagc ttttagatcc tgaattttta ttgaacctcc 1779361 atatttctcc gattggtaaa aattagccta tacaccggaa gctgtacgtt tataaaggat 1779421 cagagaatcc cataaccagt aaatcactgc agccgcaata cttaacatat aataaaagta 1779481 cgattgcaat gtccatgcta ttgacgcagg ttcattgata acaaaaaaca ggaaagctgc 1779541 gataaaagca accacactgt aaatcaatag gtacatgaca ttgaaagttc tcgctttttt 1779601 ctgcaacttc atttggagcg gaacagcaaa aaggccatac accacaaaac cgtataataa 1779661 agcaattgct gccgtaaaca atgcaattat catatcgcca tacataacga aagaataaaa 1779721 ccctaataac aaaccaaatg taaggctgga tagccctaat gtcattaaat aatatgatgc 1779781 gatttttttc attttttcac cccccttgtt tgatttattc acagtgctgt tagtataaat 1779841 tcacaacctt tgtatttctt ttatcgagat gtcttcccta acgtgctata cgcaatgcgc 1779901 taataaaagg tttcaaaaat gacgttcttt tattagataa tacgctggct gaaaacgcct 1779961 ctcctgattg gccaaagcgc gaatgaaaaa agtgcatgaa tacctgccca acagacagaa 1780021 taagaagagt tgatatttca acacttttcg taaaggggtg aaaccaatga gtaagaaagg 1780081 tattcaaaat tcaagtattg aacaaataag aaatgaccat gagactgaaa cagcttttaa 1780141 agcagatgat cctaaaaaac acggttccga tcctaaaaga acgaaataag ttcttacccc 1780201 cactaaaata tcaataatct ggaggaagta aagtgactca aaaaaacggt gcagacagac 1780261 ctgatgatta taaaagattt tcttcattag acaaggaata tgattttcag caatctatac 1780321 gcagcaatac tgagacagaa agtgtaaaca ctgaaacaca aactcataac aaagaaaaca 1780381 aaaatgacac aacagatgtt gccgggaaat actttgagcc ctcagattat aaaggaagca 1780441 cgcaattaga aaaaggattg gctgaaactc atgaacaggt cagcgatgac tattttgaag 1780501 ggacaatcga tcaaaatttg gactagccat acaaacggaa ctaacttaaa agaagtcagt 1780561 taactctgtt tttagaaaca accacagtaa aagtagccaa cccccaccga ataagatggg 1780621 ggttgcacgt aagtagcctg tttaatattt aaaacgatta atgacggttt gaagttcttc 1780681 tgccaactga gatagagatt ctgcggcata ggagatttcc cccattgaat gaagctgttc 1780741 ctgtgatgaa tttgcaaccg cttctgtatt tgctgacgtt tcttttgtac cagcagccaa 1780801 tgtatgaact gtgtgctgaa tcacttcaac gcctgaagta agctgttgag ttgctgctgc 1780861 aacttcttgt atttgagaag tgacctgttc caccaggttc agtatttcat tgaaatttcc 1780921 tgttgtctct tgagaaagaa caatacctga gctcacattt tcttgaacaa ctttaatatt 1780981 atttaccgtt tctatcgatt cgttttggat ggtcgctacc accgattgga tgtggtttgc 1781041 agatttattt gtttcatccg ccaacttccg aacttcttct gccaccacag caaatccttt 1781101 tccttgctct ccggctctgg ccgcctcgat cgctgcattt agtgccaaca aatttgtctg 1781161 ctctgaaatc gtcgtgataa gcgaagagat atcgctgatt tctgctgtgc tcgctaccaa 1781221 tgtttgcaat ccattgccgg ctgaatctac agatttatca atgaatttca tctggtctaa 1781281 catcttgttg acggacttag agcctatttc agccttgtct ctcatcgaag aagaaagatc 1781341 cgctatgttc cctgtatttg aagcgactga tgatatactg tctaataatt cagtgatgga 1781401 ttctgcgctc ttttctgtca ttgagctttg cttcacattg ctgtcggcag ccatctgcat 1781461 ggctcgtgaa atatgttcag atgttgattt cgattcttcc gcgcttgccg ataattcttc 1781521 agaggaagcg gcgacttgtt cagatgagct gctgatctgc ttcacaattt gagttaatga 1781581 atgagtaaaa gaattaaaag attgggcaag ctggccaaat tcatctttat ttttcacaat 1781641 gacttttttg gttaaatcag cctcgccgtg tgcaatttcc tccagctgct tatttatgct 1781701 tcttagtggc accataatgg actttaacag cattatgctt agaacaatgc ctaatattac 1781761 tgatatccct gtgacaatga taatgagcga ttgactcatt ttcccattgc cctgtatttc 1781821 atcctttaga tcctctacct cttgatccag gcgatcagac agcttattga cagccggagc 1781881 tacgccttct tttcttattg ttctttcttc tccaaaatgg atggtttctg cttttttagg 1781941 atttgaagag taggctgtta ctacttgctg attcaaagct ctatactgag taaaacttgt 1782001 cttaatgtct tcaatattgg attgatactt ctcttcatca atcaagtcat taacccggtc 1782061 aaggctcttt aagacatcgt ctgcttttcc cttcataccc tcgtcgtatt ctttgtctct 1782121 ggtaatcaag aagcctcttt catcatttga taacccggtc aattcatatt ggatgtgttt 1782181 tatctctttt tggaattcca ttttgtcttt aagttcttca ttctttttca cagtagaaga 1782241 aatcataaat actgaggagc ctccaattcc aataattgaa acaactaata ttgatataat 1782301 ccccagcaat tttgttttca ctttcatgtg tcgttttccc tttccgcaca atgtaatggc 1782361 tgaaataaaa tatgttcaag cgcgtttgaa tccaattcgc ttacgctcat gtccataata 1782421 tcgacacgtg ttatcaagtt ttatagtgat attcttatat gaataagcaa attctttacg 1782481 tctctgaact tacagaaaaa ccttaagtaa aatttgcagt cttttgcggt atgtaagtca 1782541 ctcttattcg tttttctaaa aaaggctttt cccacctcaa attggctgaa ccggctgttt 1782601 tctcgaaaat ataatacaat acgcagcata atatgaagga gcgaaactta aatggggatc 1782661 atcaatggta aagaattcat tgaccgattg aataaactag aaaacgaaat atggtatgat 1782721 ggcgaaaaaa taaagggtaa catttctgag catcctgcat ttaaaggaat aatcaaaaca 1782781 aaaagctcac tttatgaatt gcaaacaaag gatgagttaa tacatgaaat gacttattgc 1782841 cttcctggag atcataatcg aatcggcctt tcctatctcc agcctaaaac aaaaaatgat 1782901 ttgaaaaaaa gaaggaccat gattgaacat tgggctagac atactcatgg aatgatgggg 1782961 agaagtccgg attacatgaa tacggttatg atgagctttg cttcgtcagc ggagcttcta 1783021 aaagataaag agaattgctt tcctgaacat atactagata tgtatgaaca agctgctaag 1783081 catgaccttt cctttaccca tacattcatt actccgcaag tgaaccggtc acagtcctat 1783141 tttgggctaa gtgaaaaacc gatatctgct aaagtcattg atagaaccga aaaaggttta 1783201 atgattcatg gcgcacgact gcttgccaca caaggcgggt tgaccgatga aatcttggtt 1783261 ttttcagcgc ctaaattttt ctttgaaaca gatgaagctt atgctttttc aatcccttct 1783321 aatacaaaag gcgtaaaatt catcacaaga gaatcatttg tattaagcga ctcttccttt 1783381 aatcatccct taagctcaag gtatgaagaa atggattcaa ttgtggtttt tgatcatgtg 1783441 ttagtgccgt ggaatcgtgt gtttttttac gataatgtgg aagcagctaa agattttatg 1783501 acaaaaagct cttttcatgc ctttaccttt caccaggttg tcattaggca aatgataaaa 1783561 attgaatttc tattaggtgt tgcacagctt cttgtcgaca ccattaatgt ttccgaatat 1783621 cagcacatcc aagaaaagct ctcagaaatc attgtgggat tggaaacaat caaagccctc 1783681 attgacaaat cggaaaatga tgctcagtta gatgaattcg gctatatgcg cccctgttta 1783741 attcctcttc aagtcatcag tacgatcatt cctaagctat atcctcgatt tactgaaatc 1783801 atacaattaa ttggagctag cggaatggtg acactgccta ccgaaaatgc atttgactca 1783861 gagatacggg aagatcttga ccaatatctt caagcaacca atacaaatgc tgaagaacgt 1783921 gtgaaaattt tccgtttggc atgggattta acaatgagtt cattcggaac tagacaaact 1783981 cactacgaaa gatatttttt cggagatcct attcggattt caagcaggct gtataccagt 1784041 tatccaaagc aggagcagtt gaacatgatt aaaacatttt tacatgcaga tacagaacat 1784101 tgaaaaaaca gcgggaaaag atccgctgtt tcgtattttt tattcaggaa actgaacatg 1784161 gcccggtact gtataggctt tggacgttcc gctttcaggc agctttggaa tggtgtcttt 1784221 cacaactttt ccgcggatgt cagtcattct gactttgaga gagccagtac ctaaattcgt 1784281 actcacaaaa tggttatagt ccattttctc catgttgatc cacttaccat ccttttcata 1784341 ttccattttc ataacaggat acttgtgatt tctgacttgg attgctgccc accacctgct 1784401 gctgccttct ttgatccggt acgtgaaatt gccggtgatt ggggctttga caacacgcca 1784461 tttaatattg atttttccgt ctttcatatt gccgatttta cggaaggcat taggtgacag 1784521 atcaagagct ccccgagcgc cttcgggata aagatcagta acatatacgg ttgttttccc 1784581 ttttggccct tcaacttcca aataagagcc ggcaagtgcc gcttttactc ctccgtaatt 1784641 gagatccgcc ggatttattg cagtaatctc catatcggaa ggaatgggat ccagcaggaa 1784701 agctcctcct gaatagcctg accctgtata cgttgcataa ccttcatgca ggtcgtcata 1784761 tgctgccgaa gcttgcgggg aaaaacagaa gatcgtcaac aaaaccatac caacaaatgc 1784821 actcatgatc tttttcatat ttggtcctcc tcaaaccaga cttcaaatga gaatcattat 1784881 cattataaga ctcaatccat ctggtttgaa agaggaaata gattcatagt tgattttaag 1784941 gcaaattcac tatcattcat atatcaaatg taggtactta tgaaaaagcc aatacaaatg 1785001 aacgaatgtg cacttcagcc gaatgtctta tttttccctc tcaaaattcg catttcaata 1785061 acgaaatgaa acaggctgtt ggcctgataa cagctataca ggaaaagcta tttttccccg 1785121 ctcagtttca acttagctgt catcatgatg ccaaagatca gcacaatcgg aacccaaata 1785181 atgaagtgat aaaaatcagg ctcagccaga gcaacaataa tagcccctac acaatacaaa 1785241 ataatagcca gtgctcttaa cacagtatct cttaagaaag tcttcttttg cttcttaaaa 1785301 aacaaacggc cggatatatc ctctaaaaga gaagccaaag tgccggtcaa cacagttgaa 1785361 gaaatacctg caatccccag tttttttgct gctgtagttt gaatccccat agaaatgctc 1785421 atgagtataa ttagaatgtg cacaggaaca aatgcccggt aaaaagaaag acaagcaaag 1785481 acaaacaaaa tgaatgcttc aagtgcgagg gcttttgtca cagcagaagg ccaaagggta 1785541 ttttccgcct ttccgaccat caatgtagca atgatcacgc cgcatataaa tccgattagc 1785601 gcagtcaagg aattaaaaac agtgacctga atggatttgc cgatagctaa ccccaataat 1785661 acaatgtttc cagtcatatt agctgtgaac acatgtccca ggcttaaata cccgattaca 1785721 tccacgattc cagctgttaa acataaaagt gatagcaagg tgtttcgata agctgctgca 1785781 gtcaacggtg tatcaatcct ttcttctatt tcaattgtta gtatgtcttt tggcgcaatc 1785841 tctatttttt aagtaaccca acattaatta ggaagataga acctattatt cctttccatt 1785901 aactgtaata ataatccccg caaggaaatg attaaaattg aaaggaagca tattgtgatg 1785961 aaacgacttt gtttatggtt caccgtcttt agcttgtttt tggttctctt gcctggaaaa 1786021 gcattaggtg cagtcgattt tccgaatacc tcaacaaatg gccttttagg ttttgccgga 1786081 aatgccaaaa atgaaaaagg catctctaaa acgggcacaa cgggtggaaa aaacgggcag 1786141 attgtttaca ttcaaagcgt aaatgattta aaaacccatc taggaggatc cactccgaaa 1786201 attttagtgc ttcaaaatga tctttccgca tctgcgaaaa caacagttac cattggctca 1786261 aataaaacac tcgtgggctc ttacgcgaaa aaaacgctga aaaatattta tttaacaact 1786321 tcatcagctt ttggaaatgt catttttcaa aatttaacgt ttgaacacag tccgcagatt 1786381 aacggaaata atgatatcca gctttattta gattccggta tgaactattg gattgatcac 1786441 gtcacattct caggtcatag ctataatgca agcggaagcg atttggacaa actcgtgtat 1786501 atcggaaaat ccgcagatta tatcacgatc agcaactcaa aatttgcgaa tcataaatac 1786561 ggtttgattt taggataccc ggatgattct cagcatcaat atgacggcta cccccacatg 1786621 acaatcgcca ataattattt tgagaacttg tatgttagag gcccaggtct gatgagatac 1786681 ggttactttc atgttaaaaa caattacagc aataatttta accaggcgat tacaattgct 1786741 acaaaagcaa aaatatattc cgaatataat tactttggga aaggcagtga aaaaggcggc 1786801 atccttgacg acaagggcac tggttatttc aaagacatag gcagctatcc atcactcaac 1786861 aagcaaacct ctccgctgac ttcttggaat cctgggtcaa actatagcta tcgtgtccaa 1786921 acgccggaat atacaaaaga atttgtcacg aaatatgccg gatcacaaag tacaactctg 1786981 gtatttggct actgatataa aagaggccct gcgttaaaaa cgctgtgcct ctttttatac 1787041 tataggctat ttttaagcga tccttgtaat tccatcaaga tccagcgtcg gtcaaactaa 1787101 aaagcatatg ttcttttcca caataacttc ttaactggct ttcttattat accagtttat 1787161 cgcaagtgaa aagaaatcat tgttctgaac ctgtattaaa tgaacgatcg tcccacaaac 1787221 tacttaaaaa cccctaaaaa ggatgatgga tatgtgcggc aggtttactt tgtactctgc 1787281 atttgatgat attattgacc agtttgacat cgatcaattt tttcctaaag gtgaatacca 1787341 gccaagctat aatgtcgcac catcacaaaa catccttgca atcatcaatg atggatcaaa 1787401 taatcgctta ggcaagctta gatggggact tattccacct tgggcaaaag atgaaaagat 1787461 cggttataaa atgatcaatg ctcgagccga aacaattacc gagaaaccgg cctttcgaag 1787521 accgcttgtc agcaaacgct gcatcatacc agcagacagt ttttatgaat ggaaacggct 1787581 tgattccaaa accaaaatcc caatgcggat caaattgaaa tcatctgctc tttttgcgtt 1787641 tgctggctta tatgaaaagt ggagcacaca tcaaggatac cctctttata cctgcaccat 1787701 cataacaact gagcctaatg agttcatgaa agatatacac gaccgaatgc cggttatatt 1787761 ggcccatgat catgaaaagg agtggcttaa ccccaaaaat acaagccctg attatctgca 1787821 aagtttgctg ctgccttatg atgctgatga catggaagca taccaggttt catcattagt 1787881 aaattcaccc aaaaataatt cagctgagct tcttgatgca gaaaatcata tgtagtgatt 1787941 gaaaaaattc tctagcaaga acttgtcaaa tagctttgtt ccttaggtgc caatccctct 1788001 agtaattatg aatatttagt acatagatca attagttatc tttagcatca gtttgaaata 1788061 attttattat gtaaacttaa ataagcaatg ttattccttt catataaaat agtttacatt 1788121 tttataaaat cgcttcactt ttctattttg tcagcaaaaa aactgaacca cattaaactt 1788181 atgaaacctg ccgcacctgt ggattgcaaa tatgatataa gcccatagag gtaaatccat 1788241 acactttccc tcctaagaat taaatgaaat ttctttcatc ttacatgaag gtcttctttc 1788301 ttttgtttat ccagtgtaat acttaataat atgttgatga atgcagctgg aaaatatata 1788361 aatcccactc caagaatgcc tagtatcgta cttaaactta ctatgtaatt ctttgtcatc 1788421 gtttgactgt caatcaatat tagaagtgaa atcaatccag ctaaaacacc tataaaccaa 1788481 gcatcgccaa cagcataaga atcatccagc atccctaacc atcgccccaa tatagagctc 1788541 ccaatggcag tcaaactgga taaaaatatg agtgctttca tttcttctcc tcctttaaag 1788601 ccaatcaaac tggtagaaat cggccattga atccccatta tcgaatggtt accatttcat 1788661 ttccacatta acattttaaa gctcattaca atacgattca agcagaaaaa ccctacataa 1788721 cgtatatata gggatttaat aaaacacagg ccaaaattca gctctatcta ctttaaaaag 1788781 atatgaaggg cagctgtgtg atctgttacg tctttacgta ccgggatatt tcacaacagg 1788841 cactttcttc ttgcgcagag aatcaagcat gactgatcca gcattcaagt tgctttgtac 1788901 taattcttta ggcgtcaatg ccatccactg attgagtgac acatctgcat agcggttact 1788961 tttgaacatt tctaaaaacc ataatgtttc tgtaccagtg ttttgtatat agtgtccggc 1789021 attagaaggc acgtatccaa cgtcgcctgc tctataatca aatgtgcggg cagtcccatt 1789081 tccgataaat accgtcattc gtccctgtcc tgttagataa tattgccact catcgctatt 1789141 gggatgccaa tgaagctctc tcatcgcgcc aggctcaatc tgaacaagtg cagcggctat 1789201 cgtttttgaa attgggaagt tagaagaatc cacaattcgt acactccccc ctggcatttg 1789261 aattgggggt tgatttaaca gctcgtgttt aaaggtcatg gggacttttc catatggtga 1789321 ctgaatgtct tcactggcga ctgatcccgg cacattccct tggtagatat agacttgctc 1789381 agacggaaga gagttgaaag cattctccgg gacaccgaaa tttgcagaca gaacatcttt 1789441 tggtgtgtgt gcaagccaat ctgaaatggt taacgttgaa aactcagaaa agttcccatc 1789501 atcgaaaacg agcagaaact cgcagtgttc caatccctgt atggaatgcg gaattcctgc 1789561 cgggaagtac caaaggtcgc cgggaccaac atcagcaatg aaatttcgtc cgtcttggtc 1789621 aacagcggtg atacgtgccc gtcccaaaag catataagcc cactccgctt gcttatgcca 1789681 atgaagctcg cggacgcctc ccgcagttaa gctcatgttt acacctgcaa tcgcagtcga 1789741 aatcggaagc tgtcttacgg tgatttctct tgaccagccg ccgtgatcta atttcatggg 1789801 agcgtctgag aatgaaaatc tcaagttagg aatcataccc tcatctgtaa caggcggaac 1789861 aaatatattc ggattttgaa tatcccgtat tatatttcgc gggcctgtat caatagctcc 1789921 agctccatca cttcgaatag gctgcggcac gtttctgtct tcatgattga ttggttgttg 1789981 ttccaacagc atgcacctcg ttttagaaat gaacaagatt ttatttcagc ctatgcagaa 1790041 tcttagattg ctgtgcctag gaatccgcaa ataaaaaagt gaccaccaat gtgatcacaa 1790101 atacatcaaa taaactattt tttataccat ggcttcttat gtaatttgat tgcttctgtc 1790161 tgttttttct ggcctgtcct ccactccact tttactaata catcatgacc tatcacttca 1790221 tcttcaggca tataatcaaa ggtggaaata tggtcctcca tgcgtccccc acccggcatt 1790281 tcatcacctg tgtactccga taagtcgtac tcatctacgt tatcatcttg atacttttcg 1790341 ccatctacat acagagtaat tctttcaaca acagtccact tttcttcctt cttactcccc 1790401 tgccaatata gatttagaaa ataattgggt ccaattgaag ttttgtctga tttttcaagg 1790461 ttagacatcc acagtccgct tttcccgctg ccctcatatt tcactttgtt ccctgacacc 1790521 attacaaata atgtgatgat gcagatgatc aagaatccag caatgatcaa tagccatttc 1790581 ttaatattgt tcttttttct catgtttttc ctcactttcc taacttttta gtaggaaaat 1790641 acgatcaaaa tgttaccgaa aagaaaataa gaaagggcta atgatctaac agatgactgt 1790701 ctaaactttt gacttaaatt aaagtgcttt ctaaagacaa gattaaaacg tataacagct 1790761 cttaaatgca ttttttgttt cattgagtca agaaccttaa aatggctttt tattattaaa 1790821 aatcaagcta gtgtattaag taacttttca aatttattta tactcatgat ctcgtgagtc 1790881 acaaatctcc catcaaaaaa aacgctaaaa gttgtccaaa tagctggtga cttttgtgcc 1790941 tcttctttcg atgataactg aattgactga aattgaaccc ctttcttttc agtcaattcc 1791001 cgcaaatcat ttatcatgcc cactgcaaac ggacactgag ctgtatagta tatcgtaatc 1791061 cccttttcat tgatagaatc acttttcacc tggctcttaa atgcaggaga atctgcaagg 1791121 ccattccaag tcaaagccat taattgaaaa taaggggcag cttcatcttg tagagtaaac 1791181 cccatatgct caaagaaatg cttatcactt aaatagggca gttttttctt gcctgcgata 1791241 tggataatgc catccatgcc gcacgctttc gcatctgcta tacatttgtc caacaatcgt 1791301 ttcgcatgac cgttattttt atatctgcca gacacccaca gacaattaat gtacataaaa 1791361 ttaggcgcat tgataggcac ccatgcctca ttcgcaggta ggtattcaat aaagactttt 1791421 gcccgttcat gtaagcgata gaacaccaat ccttcatcca ttcgagcttt gagccatctc 1791481 ttcttttcat taactgcatg ctcatattgt ttcgtgctta atgcacagca aatatgattg 1791541 tcttcaatat tgtcctttgt gatttcaatg tagcacatct cctctttccc ccctttaaca 1791601 taattacatg gaattcaact tcacacttta catgcctaat agaataaata cccgttccaa 1791661 cttaaatact ttttcttttc cattttgcca attaactgta aaacccttct tttattcaga 1791721 tattatcttg attcctatat cacccatttc aaatccaaag tgtgttcatc tttgaggatt 1791781 agatgcactg cttatgctat aaatacagta cacgaagttt tttatttgaa gtaatatttg 1791841 ttacgggaca gcaatagtaa ataagtgata aaaggggaat taaacttggt ggaaaaatgt 1791901 tattcttgtt taatttgcgg atacaaagga ttaattcaaa atcctttgta taaaggcgag 1791961 tatcaaaaaa cgtttgacat ttgtccatgt tgcggttttg aatttggcta cagtgaggat 1792021 catgatgtga ggttaggttt tattgtaact cctgatcatt taattgaggc tgcatttcaa 1792081 ttgtatcgca aacaatggct tgagagcggg atggtaattg ctcatccgga agatattcca 1792141 gaagaattga aaaatggcaa ttgcttaaaa tttgaagttt tgttgaaaca attgaaaaaa 1792201 ctaaatcttg acatagaaaa ttttgaaatt agcggttttt aatgatgaaa caggttgcac 1792261 ttgtttaggt ttcactgtca ttatcagtaa aatgttaagt tgaaatgcgc aatcagtcac 1792321 aaagtctcta ttcgtattca ataaagactt tgtgatcatc gacaaacatt tcactcccat 1792381 cggataaagt atccaaaagg cctcctctgg ttcttctcta tagtcattaa tcacagtcac 1792441 tttgacattt gactcagcta tgattggttt tccaacaatt tttcgttttt tcctcaggca 1792501 aagtaagaga tcgaatcatc aaagccattc catctttact gtctaattaa cgccatcttc 1792561 agtgaattta aaggtctgtt ttaaattgcg tccttcttgc cccttctgtg tccaaattat 1792621 aacaacctct aattcagagg ccttatctgc cagcataaaa tgattgaact tcagcggtga 1792681 gccatcattt aaactttcag ctaacatttt agaatcttct tttggtttga cacaattttc 1792741 atcgggacat ccaaaaagcg aaaaccttgt gattgaatta gggtcatttc tatacaattg 1792801 cacatccact gtagctgctt tttcccctat atttttgact tccaaggaat atacttgata 1792861 ttctccttta tgaggtctcg taaattcctt tacatttttt gcttcactta cttttactga 1792921 ccactggtct gttttttgtg taataggcaa caccgtaaaa gtcagggcat gcgcttttga 1792981 ttggcaaaac gtaaatccaa ctgctgtaaa aacaattaca gaaaataata cccttttcac 1793041 ttcatttatc cctccttcct ttcactggcc gctccttaaa gaattgattt tgagcaatct 1793101 acaagctctc ttaaccaaaa ccttacctga ggttttgtct ttactgctct gcatttattt 1793161 ctttcggtat ccgagaagga gctttgggga tttttctcaa tctgctgtta atcacatcag 1793221 aagagtatag cgtaataatc atacttcccc catacctttt tgcccgaatt aagattggtt 1793281 ggttatattg gttttgaaag cgaaagtcag gacctcccca gcttaccgtc gcatcccgtc 1793341 cgggcggtac atatggtaca cttctagtat gagaatagcg ctgaacgatc tgcagtcctg 1793401 cacgatctac tgcattaaat agagttgagg acacctgaca aattcctcct cctacacctt 1793461 cagacaactc cccttttaca ataatgggtg cacttttata tcctttgttc cgagttctca 1793521 ttcccacaac ttggttaaac gaaaacgtct cattagggaa aacaacgtga ttgtcgattg 1793581 cttttgcaga aagagaaata ttgtgtgaac ggcttttatt gcttgagtta aaatacgtca 1793641 cgtactgacc aagctgctgc gtactgatgt gagctagcag ctcgctgtca actttcggat 1793701 aaatgttcat ttccggcact tctatcttgg agggaccttg cccataaaaa tacgcataaa 1793761 acttttccat aaacgcctgt tgatacagtt tgtagccaac cctgcccggg acgatgcttc 1793821 catgatcgtt aaggacagca tttatcggct cacggtacac tttctgatca agctgtttga 1793881 tgaatttact gtatttttca tagtcaacca ttggagtgcc gggaagaggc attgtaaagt 1793941 cttcacggtt aacagtggca atcgtccgtc cttgctgtgt gaccgttaaa ctgtcctgcg 1794001 gctcactcgg ctgagccaat aaaaaaagac cagtgatcaa aatttgtatc ataagtcggt 1794061 ttacctccca atcattagta tgaacagccg cttatccttt gatgtatttc ttcccatcgt 1794121 ttgtttgaat ctttagacgt tgataaaaac cttcataaaa gagcttagct ttatgttcac 1794181 accgatccct gagctcactg aggcacacgg ttcattcagt cggcaagttt gaagtagttc 1794241 agcatctccc agtgatgagg gatgcttttt tgtcttgtca aaaatgaaaa gggtctccta 1794301 taacaacaaa aaatcaatcc atttcaatat ttttttattg agaaacgata aattttttgt 1794361 tacattcaat tagacaacaa ataaatgagg tgcttgttat gaatcgaatg tcgacaattt 1794421 ttttaaagat agctttggtt cttattggaa ttccaattct tgctttatgc atttttttag 1794481 tgcctaaggt agccaactat tcagcagaat tatttccaaa tatcgcttat ataaaatatc 1794541 tcgttttcat ctatttgtat gtaacggcga taccttttta ctttgctctt tatcaagcgt 1794601 tcaaactttt aagctatatt gacaaaaaca aagctttctc gggtttgtct gtaagagctt 1794661 tgaagaatat aaaatattgc gcagtcacta tcagtatctt ttacgcagca ggcatgcctg 1794721 tcttttatct gatggccgag atagacgacg ccccgggtat cattgtgatc ggattggtta 1794781 ttatttttgc ttcaatggtg attgcggtct ttgctgctgt tcttcaaaaa ctgttaaaag 1794841 aagcgattga tataaaatca gaaaatgact taacggtctg aggtgatgac atggcgatta 1794901 ttatcaacat tgatgtgatg cttgctaaga ggaaaatgag cgtaacagag ctttcagaga 1794961 gagttggcat caccatggct aatctttcga tattaaaaaa cggaaaagca aaggctattc 1795021 gattatcaac tttagaagcg atttgcaagg ctttagaatg tcagcccggg gatatattgg 1795081 aataccgaag tgatgaagac acaggattcg taaagaaaaa atatgaagga tcaacagaaa 1795141 aataaagtga ttggcggtga gcttatggac ataaacttat atccatctag ctgctatact 1795201 aagcgtccct ttcatacacg aagaacacaa ctatggagga ggcatacatc atgagagcca 1795261 taaaacaaat cgtccatttt ggctgggaac aagccctttc atgtttgttt cctgccgtta 1795321 tttttgcctc tttggctatt acgcaaatca tcccactgcc cttcttgccg cggtatgact 1795381 ggctgctcat tatctgcgtt ctcatgcaat tgtggatggt gcgttccggt cttgagacac 1795441 gggatgaatt aaaagtgatc acattattcc accttattgg gcttgctctg gaacttttta 1795501 aagtccatat gggctcctgg tcttatccag aagaaggata ctccaaaata tttggagtac 1795561 ctttgtatag cggctttatg tacgcaagtg tagccagtta tttgtgccag gcatggagaa 1795621 ggcttaaggt tgaactggtt aagtggccgt ctttttttgc agttgttccg cttgccgcag 1795681 cgatttattt gaattttttc acccaccatt tttctataga cattcgatgg tggttatcag 1795741 ggcttgtcat cattgtcttt tggcaaacat gggttacata cgaggtgaat ggagctcgtt 1795801 accgtatgcc gctcgcactt tcttttatac tcatcggatt ttttatatgg atagcggaaa 1795861 atatcgctac gttttttgga gcttggaaat atccaaacca aatcgataca tggagtctcg 1795921 tacaccttgg aaaggtaagt tcatggctct tgctagtgat tgttagcttt cttatagtag 1795981 catcattaaa acaagttaag gagcagagtc ccacaaaggc agagatggat gaatcttttt 1796041 cttagcatac gcatacaagc tcccaaatag agtgaaaagc aacgttcaaa tggttgcttt 1796101 tttcttttat gtaactctgc cggtgagtat tcatcttctt caaatttcat cgcaacacga 1796161 taactgattc agattacaac tgctttcaac actttgacaa actcatgcgc cgccggcgtt 1796221 atctcttcaa atgaatgtgc gatgacgcca atatcgcgtg tgaccctagg aaagatgtcc 1796281 tttttaatca attgatgcgg gacggatgaa agtgtaaagt ttgaaatgat gccgataccc 1796341 aagttatttt tgaccatatt aatcaaggtt tcggcatttt gcacagttaa gttttccttt 1796401 aattcgatgt tgtattgcga aaatgcgttt gacatcgcga tttcatgacc gcctttacaa 1796461 aaaatgaggt catcttgata tgtttcaagg tcgacatgct tttcaagttt taattcgtca 1796521 cgctgcggcg ggatgacggc caccatatag tcgttacaca atagctgatt ttcaaacggt 1796581 tcaaatggag atgctgcgat cccgatatca accgtccgat cttcaaccca tccttttatt 1796641 tggtcagagg ttccttcgat caattctatg cggatcagcg ggtagtttga tctgaatgcc 1796701 gcaatcgcct gtggcatgat atttgttgaa actgcaggaa atgaaccaat tttcaccttc 1796761 ccgtttaaca gcttgttttc ccggttggct acttgatata ttttgctttc aattcccttc 1796821 atttgcctcg ccagcagcaa tatttctttt ccgatgtcag tcagcattaa accatgatgt 1796881 ttatccctga tcaataattt gagctgcagt gagctctcca ggttttttat cgctttactt 1796941 accgccggct gagagatgaa caattctttt gccgcttctg taatatttaa tttctcccca 1797001 acttttacaa atatgtgaag atggttcatg ttcataacca tttggttata cccccaataa 1797061 taaaaatgta tttcagttat acataaatgt aacatatgat agaaaccagc acgatatttt 1797121 aacaagaaag gcggcttcat tatggtaaaa gttatgctgg gaatcatatc tgtcacactt 1797181 atttggggtt atacttgggt tgcgatgaaa gtaggaattc atgacatccc cccgctttta 1797241 ttttcgggtt tgcgcctgtt catcggagca gttcctttat ttctcattct cttcatccaa 1797301 agaaaaaagc tttcaattca aaaagaacat ctcaaaagct atatcatcat gagcctgttg 1797361 atggggctgg gctatatggg gattttgacg tatggaatgc agtttgtcga ttcagggaaa 1797421 acctctgttt tggtatatac aatgcctata tttgttacgg tgatcagcca tttttcatta 1797481 aacgagaaaa tgaatgtgta taaaacgatg ggactggtct gcggcctctt cggactgtta 1797541 tttatatttg gaaaggaaat gctcaatatc gatcaaagcg ctttatttgg ggagctgtgc 1797601 gtacttgtgg cagcgcttag ctggggaatc gcgaatgtgt tcagcaagct acaattcaag 1797661 catatcgata ttattcacat gaatgcctgg caccttatga tgggagccgt catgttattg 1797721 gtgttttcct ttatatttga ggcggtccct tcagccgagt ggacatatca ggcggtgtgg 1797781 tcattgctgt ttaatggctt gctttccacc ggctttacct ttgtcgtatg gttttgggtg 1797841 ctcaatcaaa tccaagcgtc aaaagcatcc atggcattaa tgtttgttcc cgtattggcc 1797901 ctattctttg gatggctgca attgcacgaa cagatcacca tcaatattat cctcggcgca 1797961 ctgctgatat gctgcgggat ttttatgaat acatttacat tttcacgacg gaaagtgtga 1798021 atgatataca tttcccctgt catttgggct tcatgtgaca ggagaagact attacgagaa 1798081 agtcttctag aatcctgacg acagcctatt aaacaatgaa aaaagctaat gtctgcatgt 1798141 agacattagc ttggctggcg tttaggctgg tgagaatcca gatacttttt tattaccatt 1798201 ctggctgatc aaactgaaaa ccgtatagac cttttacttt aacatctccg caatctggat 1798261 cttttgtcaa aatcaaataa tgagtcttat aaggcatcgt ctcaactcga tcagttgcac 1798321 taaaatcaaa atgatccccc gagaagtttt tttcactaac ggttatttca tatcctgaca 1798381 aagtcattcg catgattctt gcgttaattg tacatccttc agtatcgaaa atggtgaatc 1798441 tgtacccaaa gtgagatgtc caatggtttg aatttaggtc atcagacttc ataaaccatt 1798501 tttcattctc tgtcattgta aaactcactt tctcctcatc tttcacgata acggccgaag 1798561 cttcccctac atggatagtc aaagccaaaa gaaatgtaaa agctaacatc aacatctttt 1798621 tcaaaagagt tcctcccgat atcttttact tcaatatatt ggaagggtct tttctgatca 1798681 agacagtctt ctccaaatga atctttagca ccatgaaatg agccttaata agaacagttt 1798741 taacccaaat caacctctat tcgaaataag gcttaccaat ctatattctt tttaaaagtt 1798801 tctgcatttc tttatttagc tcctagacac atataaaaaa tgctcctata agttcaggag 1798861 cactacaaaa aactgctaaa gtgttttcta tcgatttatt gtattcatta gctcaaagaa 1798921 atattcaggc ttttgagtct tatttagctt ataccatgaa cgcaatgtat ctggtgcaaa 1798981 tacatctaat tttttcaata cttctaccgc aaattccaga ggagcaattc ctgatgcagt 1799041 aaccaaattt tcatcagata ctgcaggccc cttttcatag aatgtttctc ctttgtaatt 1799101 agggcagacc atattcatat agtcgaggtc attgcttgtg tgctttctcg aatttaagta 1799161 tccttcattc gcgaggccca aggttgcccc acaaattgca gcaatagtcg tgccgagctt 1799221 taaagcgtcg ccaacttttt tcaagatcgg ctgatgaata tcttctcccc aagtgtttcc 1799281 tccgggtaaa atgataagat cttgactccc aagagtacat tcgtcaagag aaatatctgg 1799341 ttttatgctt aatcctccca acgtagttat catttcttta ttaaccccta ctgtaactac 1799401 ttttaaagat gctgcatctt gtttaaagta tctccctgag tttagttccg caattaaata 1799461 tccatattcc cagtctgaca ttgtgtgaaa tacgtagaga taaacttttc tcgtttgcat 1799521 ccaataacac tccaatcaca attgataaag ctttctaata gatgactttg ctgacagtca 1799581 ttgtcagctt ttttgttgat tctattctta tgcccttgtt ctcccaactt ataaaaatat 1799641 aagatcaatt gattctatgt ttactagcgc aaaggggttt gttacactaa ctgtcatggg 1799701 aaacatttca aaggtaatac aaaatcattt gaatgaggag gcctgatgaa gttgaaaact 1799761 aaagcgtcaa taaaattcgg aatatgtgtt gggcttttat gtttaagcat tactggtttc 1799821 acaccttttt tcaactcaac acatgccgaa gcaaaatcca tagaagacac aaacatggca 1799881 agctgtataa cgaataaaaa atttgttcaa cttgagaaaa aatttgatgc caggcttggt 1799941 gtttatgcaa ttgatatagg ttcaaacaag acaatcgcct atcggccgaa tgaacgattt 1800001 gcttacgcat caacctataa agttctagcc gcagctgctg tcctgaagaa aaactcaatt 1800061 gaaaaactta atgaagtcat ccactacagc aaggacgatc ttgttacata ttctccaatc 1800121 acagagaaac acctagatac aggcatgagc ctaaaagaaa tctcggaagc ggctatccgt 1800181 tacagcgata ataccgctgg gaacatcttg ttgcaacagc ttggcggccc taaaggtttt 1800241 gaaaagtcac tgaaacagat tggggatcat gtaacgaaag ctaaacgatt cgagacggat 1800301 ctaaactctg cgattcctgg tgatattcgt gacaccagca ccgcaaaagc actggcaacc 1800361 gatcttaaag ccttcacttt agataacact ctcacgactg acaaacgcat gatcttaacc 1800421 gattggatgc gaggcaatgc tactggtgac gaactgattc gggcaggcgc tccaatagga 1800481 tgggaagtcg gcgataaatc cggagccgga agttacggga cacgaaacga cattgctatc 1800541 gtttggccgc caaacagagc tcctattgtt gtggcaattc tgtcaaaccg ctttacgaaa 1800601 gatgctaatt atgataatgc tcttatcgct gaggctgcaa aagtcgtcct taacgatctc 1800661 aaataatatg tttagccttt tgccacaaag gaaaagacat tactttttta acttctaccg 1800721 ttcatttttt gatgaacggt tctttcataa gacctctaga atcatatatt taaacaccac 1800781 aaaattaaac attattataa ttaacagcaa gttttcattt tatggaacaa gtaaagtttg 1800841 aatctgacaa gaattaagac taagcaccct aaaatccgtt ttcttttctt ccaagaatat 1800901 actccttagt gcaagccatt ataaagatac aagtgaacat acaatgcaga caactctctt 1800961 aagtctctta ttctgtgacc aatttgtaat actcatgaat atccggactc acttccaata 1801021 tttcgtctcg ttcgaagaca ctaacatatc aaaccacttg aattaacata actgaacttg 1801081 atattggtca ctggcagttt caatgcaata gaacaacatt tgttgtctca gaggttatct 1801141 atatgagaat tcaacaattt ttttataata attcatattt ttgtatcgtt gcacttggtg 1801201 gatttgactc ttttcgtgta tggaaccaca cttttatttt ttcacctctt ttgagatcat 1801261 ctgtgttatc aatctcactt aatcctacaa ttactatgtt atttttaaac ttgttcataa 1801321 gttgtccttc agaaagattg taatcttctt ttcctggagc ttttgtatcg gtaatgagaa 1801381 ttgccctttc attgtcttta agcacgacat agcctactag gctctgcatc tttgtttcgt 1801441 ctccgttttg ttcattttta ttgcagcctg caaggaaaat aatgagcata atgagcacta 1801501 tcaagcttac tccgatttta ggcatctttc ttcctcctct ttaaactcat ctttaaaata 1801561 aacaacagga tatcacccaa cccatctact tctttttgca attcataaca gcagcatact 1801621 cattctccaa ttcctcaacc ttctttttat tctttctcaa atatttgcat gtggtagccc 1801681 tcgatattat ccgcttactc atttttgcgc tttcaaatat attattgaag gccgcttctt 1801741 tctggattcc agcataaata tacttatcct tactgtcgtt tactatcgca acttccatta 1801801 aaatcgagat ttttactttt tttatgatcc attattcact tccaaaataa cttccaatta 1801861 caacataata tatgtataaa ttgtaaatgg agttgatgta attgaagatt aggaaaatct 1801921 tattgagttc tgctttatcc tttggcatgc taatatccgc ggttcccgca ttggctgctg 1801981 gcacttcgtc tgaggttgca gtaaaaaatg aagaatatga ttatgacact atataccgca 1802041 ttagtcctct gccaatggac ttccagccaa caatagaata caacggttat acttatacgc 1802101 ttacacgtca ttattttgat tactcaatcg ggttttacac ggctatttat acaaaagttg 1802161 tttaaactta taaaggagct ttttagctcc tttttctctt gttttaagca aggtatttct 1802221 ttctatgtgg tcccctatca aatacaacat caacattctc cagttctctt tgacacgaac 1802281 aaaatctaaa gtttggtttt aaatgctggt aataaaaaat tcactttaaa gaagtgccgc 1802341 ccgcaaaata cggcttttgt acactacgcc aattttatat tgaaaagcca gacctcctca 1802401 aagaggttcc agcttttctt aatgtgctat cgatcttcgt tagttcaacg ggaactttat 1802461 cattcggtac aaatgcagcc tcccaacttc tagttagggc tgatggcgga atatctgacg 1802521 gttctctaca cacatcagac attagaagat ttcaatgtag ccttctgtac catgaacgcg 1802581 aattcgttgc ccatctttta tcagcttggc agcattttca acgccaacaa ctgcaggtaa 1802641 gccatattca cgggctataa cagctccatg ggtcatcagc cccccaactt cggtgactag 1802701 gccttttatg gatacaaaca atggtgtcca gcttggatcg gtaaaggagg taactaatat 1802761 atctccatct tctaaatccg catcttccat gtttaaaatg acacgcgctc gcccctctat 1802821 aactccggag gaaacaggta gacctacaat cgctccggct gggagatttt ctcgtttata 1802881 ctcacctgta acgatttcac catcagacgt gataacacgt ggtggagata gtttttcata 1802941 taatgtgtac tcgtcttttc gtgtactgat gatttgataa tccagtttat gtgtgcgcac 1803001 gacttcgtga agttcttcaa aagtgagata gtatatatct tctttttcat gaataacgcc 1803061 cgcttctatg agttgttcgg cttctttcag taaagcctgc ttataaacga agtatcgatt 1803121 aaccatgccg tattttggat attccctaaa cccgctgaaa ttccggatga tatctatcgc 1803181 tcgttttgtt tctttggctt tttgttcacc atccggtaat tgcttcaatc gatctaataa 1803241 ctcttgttct ttcttcaaag cttcctgtcg cccttgctca aatttccgat ggccgacatt 1803301 aggctcaaaa tttttaatat tattaagaat cattgggaca agtgtagttg gtttttcgct 1803361 ccatcgagtt cttgtgatat caatctctcc ggtacatcgc attccgtatt tgctgagata 1803421 atcatagatc gcgtctcggg ttttgcttcc gccatcaaac ttagccagtt catccaaaaa 1803481 gttatcatct tttacatgtt gtaagtaatc aattacctct ggataaggac gaatcacatc 1803541 tgcgacgtct aatagcgcaa gacccatttc tgaagtaata ttatggggta cagattgaga 1803601 aagcgtatct gctgcgtttt tttcacctaa ccactcgttc attttttcgt taatccataa 1803661 tgaagcattc atagcagttc gaattagaac cgaacttttt gggttaaata aaatcttctt 1803721 taattcctga atatcttcca gaataaaacg aaataaatct gatcctgatt tcgtttggat 1803781 gttttgtttt aactcttcta tcgatgtttg actgctctca atcaaatcag acacgattgt 1803841 cggatcgttt tcaacttgag ccggcatatc tgcattgcct ctgctgggat ttggtgctgt 1803901 tttatcattt ggtatcgact ttatgaaatc tcgtcgcttt attatggtca taagtgcgtc 1803961 ttttaagagc tgatcgtgct gccccatgcc ttttaagaaa acttctctgc tgtcagggga 1804021 tgccagatga tgtgtgacat caacaaatag ccttccaccg gctttacgca tgggtgcaac 1804081 agtcgtcaac agaaaaaaag acaatcccag tggttttatg ggatccgtca tcatttgttg 1804141 atgaccaaca gaaatataga cgtgattttc ttggtcactc gcttcaggga tggggaataa 1804201 agtagtgatt ggacgactct gtacaatata aaaagtatcg cgggccaaac accattcgat 1804261 atcttgcggc tggccgaaat gagcttcgat ctgtcttcca atgcgtgcca gctgtaaaat 1804321 ttgttcatca gtcagtgttt gagccttttg ctgatcagaa tcgatctgct gtgtttctgt 1804381 tccgccttct tttcgtccgt agatagccat ttttttagtt gctattctct tatcgatgat 1804441 ttgcccatcc tgtactttaa aacaatcggc agataccaag ccagaaacca gtgcttcacc 1804501 aagtccaaaa ccggcatcga tggataacac ctttcggttg gaggtaatcg gatcagcggt 1804561 aaataaaatc cccgaagcct gagggaaaac catcctttga acgataacgg ataaatagac 1804621 ttggctgtgg tcaaatccat tttgcatacg gtaaataacc gcgcgatccg taaataggga 1804681 cgcccagcat ttactgatat gctgcaagat tgcatcgacg ccggtaatat ttaaataggt 1804741 gtcttgttga ccggcaaaag aagcatgtgg taaatcctca gcagtcgcac tagaacgcac 1804801 ggcataggca tgttcctcgc caaactggga gagatattga gccactgctt tcacaacatc 1804861 ggaaggaatg tctacttcca taatgatttg ccgaatcttc cggctgatgt taccaatctg 1804921 atctcggtcc tcaactttta gcatggtcaa ttgatccaac aacacttgta acgtttcgtt 1804981 ttgttcgatg gctttttgat atcctactgt tgtgacacaa aatccttctg gtacttgtat 1805041 accttgaatt tttgataatt cccctaaatg taaccctttt cctccaacga gcgaaagctg 1805101 tgttttttca atttcatgta aaccgagaac caaagaactc attctacatc tccccttcaa 1805161 aaaaaaatat tgacaagagc ttcctagcag gatataataa aattataaga tggatatcta 1805221 taacttttta actagaaagc gcacgtagtg tgattatatc accgtgtctg tttttgtgca 1805281 atataaaaag aacctgggaa atttcaccag gttcttttct taatttccat agctagtcgc 1805341 attaaaaaac ttggtttgag ctgattcaat cctctaagga aatcctaaag ttgggttctt 1805401 tttgaactta cttgctttgt tcgtagagtc cccattcata aattggactt tttgttctta 1805461 acagtcccac ctttaactag tataaagtta tgaggatctg gttaactact agatattttt 1805521 attttgaata aggcttatgt ttgataaaga agggttatgt aaaggtgtct gttgtgagca 1805581 agcgctgact acaaaaaatt gatagcattc tcatttaaat accattctat taacctatag 1805641 ggaaagtttt aaaaccagat ggagaatacc ctacctccag caattccaag gccgttcacc 1805701 tagtagaaaa caacctttaa ccattactaa cgattttaat aatcattgat tataaaactt 1805761 ctcaaggaac gatcagcagc ccgttagcta cccctgatta aggatgatct gttaccacac 1805821 tgttacgtta gaacttccac tactttgata tccttctgtc gccatgactt ggtaagccca 1805881 attactgccc agattcattc catggctctt ccatgcgttc acatgattgc tgaaagtgat 1805941 tgtagcgttg cttccggttg gtctcttcga ctggcgaaca ctccagtact gcgtaaaagt 1806001 agtgcgatcg ccatcaatgg aaggtgcgtt ataacgtgta gttgtatata tgtcatatgt 1806061 acccccatca ctttttacag tacctttata cgttccagta ggtctataag taccccatga 1806121 atccactaca taatattcta tgagaggtga tctcgtccaa ccatataaag ttaaatatcc 1806181 attgccattc ggcgcccaaa ctccggcatt atagtttatc gtcctaaatg gcgaacctgt 1806241 agtccaacct ttaccaacaa caaaatttcc ggtattagac caattaacac tgtaattccc 1806301 gccagaccca ttgacagcgt ttactatacc gcccccatca gtccaatttt gccagtagtc 1806361 tgtgctagct gcagaggcgg ttgccgaaaa caagctaata ctcattaaag ctgccgataa 1806421 tccaactaag aaattctttt taaacttaaa catatgttac ctcctataat attttttccg 1806481 actttgaggt agcactcgta tacatttaaa acattcttaa ttactaacgc caaagctttt 1806541 gatcgtcccc ttcagtataa taccacgaat tcatgagcaa atattaaaag tatttgtaat 1806601 tcaattacaa atacctagaa acacattata agtggtcttc ttccaccata tcctgatccg 1806661 agctcgatgt acatgccttt acggcacaca cgaatgtggc gtgtggtgca tcgcctcaat 1806721 acgcaaagac gtttgcctta ggcaaacgtc tttttttgcg ttatccgatt tttgtgccgt 1806781 ttgggacagg ctgatccggc tgcaaaagga cgacgtcgcc ctggccgggt atgccgccga 1806841 ggaccaagac ttccgattta aatccggcga tccggcgggg cggaaagttc acgactgcta 1806901 tgacttgctt gttgatgaga ccttccggct tgtaacgctt cgtgatttgt gcgctcgatt 1806961 gttttatgcc gatttcagtc ccaaaatcta tcacaagctt gattgccggt actcttgctt 1807021 caggaaattc ttccgctttt acaattgttc ccgttctgat atccaatttc tcaaagtcat 1807081 caataactgc catatcaata actccttttt ctcctattgt aaaggagata tacaatattc 1807141 ttttaactaa agagccatca ttttttatcc gaatataagg tgtttcgata caggcggggc 1807201 ggcattcctg tgcttttcgt gaaccatctt gtaaaagaag aaaggttttg aaagcccagc 1807261 gcctcgctca cgacggtaag agtttcattt ctctccatca gcattctttt tgcttcctca 1807321 aggcgaaggt cggcaatata gttctgcggg gacttccctg tctgtttttt gaaccagctt 1807381 gaatagtaag ctgggtgata atgctcgatt tctgccagct tcttaatcgt cagccgctca 1807441 aataaatggc tgtgaatgta tgcaattgag gcatagctat gggattgaag cttttctttt 1807501 atgtattgta ctagcatatg aagcgagttg gctgttccgg cctttgcttc ctctgtcagc 1807561 aagtacctga tcgaagacca gaaaggatcg agggcagctt caattcctga tcctgcacga 1807621 tactcatcaa ttttcattgc atgaagcgga acatccagta caagacattc atttcttccg 1807681 atagaacgga agcgatgctc gcactgcggc ggaatatata aaaaatgatc cggatttaat 1807741 ttcacctggc gcccctcagt ctcaagatca atactccctt caagcggaaa aagaaattgg 1807801 ctgtacgcgt gcttatgtga atgatatagc cgtgtgtatg tccgtttttc gcaaattatc 1807861 tcttgaagcg agtccattag caaacccctt cctttggtca tcttttaatc cggtaatggt 1807921 gttccgatat aggcgaaaag ccgatttttc catataaaga aactgccgcc agattttctt 1807981 tcatcacttg taaaaacatg cgttccgctc cgttgttttt tgcccattca gtcaacaccc 1808041 tgatcacttg ggttcctgcc ccttttcctc tgtgctcctc agctacaacg atattactaa 1808101 gtccgccata accatcaatg acagaaaccg tgccaagcgc tgtcaggctt tctttgtcat 1808161 acatcttgaa aaaagtttta cacggcggca tgcgttcgaa tatgtgtttg taacctttgt 1808221 gacgctcggg tgaaaaccct tctaattgaa taaattcatc tatccaaaca gatgatggct 1808281 cttgttccca cttgtatgta aatcggctgt tgtcatttgt tcggctcata attgaccggc 1808341 acaacgctgt catctggaag cactcgtcta ccttttcata acggctgtct gccaatgcgt 1808401 catcaagccc tttcggtgat gcgttgctaa tatgaaaaca aacaggtaag cctaaacttt 1808461 gataaaaaag ttcggcctct agctgaaaat ccccttcagg catatccgca gacgtccata 1808521 cgctatttgc ccttttggtt acgccaaaat tcgctctgag aagccatttc cctatgcttt 1808581 tttgaaaata agccggccat gaagctgccg ctaatcgttc aatcttgcga atgtcatcca 1808641 ttgcataatg cctctcccct atgtatactc ccttgatatt atacaatatt cagaaatata 1808701 agacatccat ttatttgttt acataatatt tttattgttt attaataatc ctgacaaaaa 1808761 tgtccgaatt gaaaatgaca ggctttctaa aatgtcctcc tcacgttcaa atgcttcttt 1808821 tgcgattaaa acagtaaagc catgcagcag acttctgagc ccccttgtcg catgaatggc 1808881 agtcttttca cttgcatagc cgttttcaat gagcagcttc gtcacaagac agacaatttg 1808941 gtcagagacg atttccgtcc gtttgtcgtg aaccttaaga agagccgctt cataatatcc 1809001 gggattttca attgcaaaat caacatatgc atgagctaaa gaaagcatcg cggaatctcc 1809061 ctttcgttcg gttacggagt ccgccatttg atcaaaaagc tttgtcagtc ctctgacagc 1809121 aagttctgct ctgatcgctt gcagcccgtt gatatggtta tacaatgacg gggggcgaac 1809181 attcattttt ttagaaagtg cagcaagtga gacaccattt accccttcct gatcggcaat 1809241 ctctgctgca gcgtctacaa tcattttttg ggtcaaacct attctcggtg acatgctcat 1809301 catcctttct ttgctttttg gatcgcctgt ctcatccgct ctgaaggtga tcgcaggaat 1809361 tttccatgtc cgacagcgag acaggaaggc gccttatcgg cgagcaattg tgcacttttg 1809421 atggcctcct ccttattcca tgtggcgaaa gcgggaaaag gaaacgccca ttttatctga 1809481 cctgatacag cgattcctcc gcgcaactga aacgcatctc ctgctattaa agtgccgttt 1809541 cttgtatcaa gaaatgacat gctgcccggt gtatggcccg gtgttggaat ggcaagcaga 1809601 gaaccaattg tttcaccgcc cgtcagcagt tggtgaggct ttgtttgtat gtgtttcgga 1809661 atacctcctt ttataggcgt ctgcggctca tcttgccgca aagatgtgtc accttggagc 1809721 aagaatgaat cccgttccga gatcatgacc tttgcatgcg gaaatgtttg tgccaatgta 1809781 tccagtgatc cgacatggtc cccatgtgca tgagtcagta aaatatgctg aagcggtttt 1809841 ccaagctgat tcacagcttg aataatccct ttatagctgc ctggcagtgc ggcatcaata 1809901 agggtgactt cgttttcttc ctctactaaa tagcaattaa ccggaaacaa tgctggaaaa 1809961 aaagtcagct gccaaaccgt ttggtactga gtaattctca tctttttatt cctcctaaca 1810021 aaaactaatg gtgttagttt tattattaac taacaccatt agtttttcaa gagtttatta 1810081 tttttttatc gctacataaa tgttaacttg tgctcgctgt ggcactgcgg cattttgatc 1810141 atacatctca aagtcacctg taaacgtgcg cagatgccgc ttatcccaag tccaaatttc 1810201 cttccacgtt tcaagcacaa tctcttcaat aggaccgatt ctggaagtga aaacggcgta 1810261 agcggaagcc ggcaaatcaa tattttcata tggtcccgga agaatgtcgt cgtattcctg 1810321 aaacgttccg actgaaaacg tataaaaccc attcgtctct tgttcataat tcgaatataa 1810381 ggcaataatg ctcttgtctt tttcagcctg tgataaaaga gcgctcatat cctgcttcca 1810441 taattgatcc cacagtgccg gaatcctcct ttcttccgtc atttccagtg cgttgcttgt 1810501 ccgttgtgat agtccggcaa atcgtttcag gtctaagtgt gttatatgtg aaaagcccat 1810561 acgatctcct ccttttttta agattataga caaagaaacc tgacagcagt gtgtcaggtt 1810621 tcatatattt tttgcatgtg atgaatggtt tcttttactt tatcccttat atgaagaggc 1810681 tgcagaacct caatatcctt tccgaactgg agcaaaaaac cgatcagcca ttgatcttct 1810741 ggaagtgaaa tcaccgcctg gcagatttca tcttcctcac aacagtgaag gacatcatat 1810801 ccgaaccatt cacctatacg ctgacgtgct gacggctgaa caagaataac caattcagtt 1810861 aaacggtcct tttggtacca actcttatcc catggcaaag tgtccagctg aatgtctttt 1810921 ctgataaatg tctgatgtaa gatggccaga tctttcatcc ggttcagttt aaaaaagcga 1810981 aaatcatttc ttaccaggca gtaggcatat aaataccagt gccccgcctt gcaaaccaat 1811041 gtataaggtt cagtttcccg aagtagtgtt tccccgcttg cgcttgtata tgtaaaagat 1811101 atcgttaaca accgatcgat ggcagcgctg attttctcgc gcagcgtctt ttgatcctca 1811161 gtatggcccc aagccgtcat gtcaataaac catttttctg tttggtgctt aaatgcttga 1811221 gtagattgct caggtataag gtgtttgatt ttttgatagg ctgtgctgtg agaaacgggt 1811281 tcatacatag atgaaacgct ttgcaaagcg gaagcaattg caaacaattc ctcctccttc 1811341 agccactctc tttcaagccg atacgtttcc atgatgccaa ttccgccccc ggaaccctgt 1811401 gaggtcacaa tcggaatacc agccctattg atcgtctcaa tatcacggta aattgttctg 1811461 acagatactt caaacagctc agcaagctct gcagcctgca cttgtttttt gctgatcaat 1811521 aacacaacca tcgctaacaa acgttccagt ttcattctgc gcaccttttc ttcttgtatt 1811581 ttccaacaaa acaatcataa cattttgata aagcttgggc atatctatta tgcggcggaa 1811641 tacacctcgc atatgctatg aaaacagggg tttccccttc ttttttgtgt tcagtattta 1811701 tttcagctac tatttccgac cggataagca tacacttctc aacggagggg atttcacatc 1811761 atgcatctta cacttcagag cgtttatcct gccataatca tcatcttttt tctgtataaa 1811821 aaaattaaaa ggtccatcgg ataccagccg ctgaagcccc gctggctgtt cacccgtatc 1811881 attcttttct cgctgtttgc ttttggactt tcaatcttca gcgccattca ccctttttta 1811941 tatggatatc tcattttggg cattcttggc ggatggctcc ttgtcttttt cgctaagaaa 1812001 aacatctctt ttgaaaaacg cagaggaaag atctattttc ggactcatat ttgggtagag 1812061 gtgattctct taactttatt tctatcaaga tttctgtatc gagtgacgga gctttatctt 1812121 acctcacctg atctaaaccg ccttggatca tacagtcagt caatcggaac ggaccctctg 1812181 acaattggcg tctgttttct gatagccgtt tattatatcg gtttttcttc ttttatcatc 1812241 aagctcagca gaaacgaact tgaacagcac gaatacaata aagaaaaaga catccttgcc 1812301 cgctaacagc gagttaagca aggatgtctt tttcaatcat gctgtgtatg atggatcatt 1812361 tgctgaagaa catctaaaac atgttcatcc tccggagagt aataaatcga tgttccttct 1812421 ctgcgcgatt tgacaagccg gagatttttt aaaaatctaa gctggtggga cacagtggat 1812481 tgcagtaaat tcagcttttc tgcaattccg tttactgcat gctcaccttg ggacaataaa 1812541 tggagaattc tgattcgggt aggatctgaa agcgctttga atgtttgcgc gactagaaac 1812601 agcgtctcct cgtccagatc agcagccgat tgttccgttt ctctaaattc agtcatatgt 1812661 atcacctttc tttattcata gttttatctt ataacaaatg cgcttgagtg caaaccagcc 1812721 tgcttgtatt ccatttcaat ctcatagttt aaatttatgt ttcaaatcag gtttttactt 1812781 ggtctgatat accctcttat gtcataataa aaaaggtcat actgctccaa acattgaggg 1812841 tgaaacacag tgaagaaaaa gagaaaaggc tgtttcgctg ctgcgggttt tatgatgatt 1812901 tttgtctttg tcatcgcctc ttttttattg gtcctgcttt ttttcaaccg ggatttaatc 1812961 aaaaaacttc cgatcgatac gaaaacgatt gttttggaac gtttaaccga ttacaaaccc 1813021 ttggtggaag aagagcttga aagccaagga ctctctaatt atacatcact catattaggc 1813081 atgatgtatc aggagtcaaa aggaaaaggc aatgatccca tgcagtcctc tgaatctctg 1813141 gggttaaaac gcaatgagat aacagaccct caactcagtg ttaaacaagg catcaagcaa 1813201 tttaccctca tgtacaagac cggtaaggaa aaaggcgtgg atttggatac cattattcaa 1813261 agctacaaca tgggggcagg ttacattgat tttgtagctg aacatggagg aacgcatact 1813321 gaggaattgg caaaacaata ctccgagcag caagtcaaaa aaaatcctga tctgtatact 1813381 tgcgggggaa atgcgaaaaa tttccgctat ccgtattgct acggtgatta tacgtatgca 1813441 gaaaaagtaa aagaaaaaac aaaaactgtt gaagaatctt tgcaggttgc aacacttgaa 1813501 accatggaat ccaaggctca tgaataagag tctatcaatt tactgacaaa agcccaaaaa 1813561 tgaatttggg cttttgccat gtttacacgt aaaaaaagcc atactgagta tggcttttaa 1813621 taatacggtg aaatcatcaa atatacaata acgcctgtaa ggcttacata cagccataga 1813681 ggcattgtcc atctcgcaat ttttttatgg cgctccacct gcatgctgaa gcctctgatc 1813741 agcgtaaaca gcgcaagcgg cacaataatt gcagaaaggc agatatgtgt aattaaaata 1813801 aagaaataaa tcgggcgcat aataccttct ccgccataga gcgtgttttc cgcaatcgag 1813861 tggtacgtca catagcaaat caaaaatagt aatgttgttg tgaacgcagc caaaataaag 1813921 cgtttgtgag ctttgatatt tttctgttta atcataatca gcgcggccaa taagaagata 1813981 aacgtaaagc tattgaatat cgcattcagc attggcaaaa tgtgaatatt cgcatggctg 1814041 aactgatcta atttaggcat aaaaaacagc actgcgatta aaccgttaat cagaactgtc 1814101 agcgtaagga caatccccgt gtaatttttc ggtttatttt ctgtttggtt catttggtga 1814161 cctctcctaa tttgtactgg ctatccaaat cgtatgcaaa ttcaaagaag atgtcaacgg 1814221 tttcgattgc ttcgtcagaa attagacaca cttcaaaggc cggaggctat tagccccggc 1814281 ctgttaggtt tacgcctctt ttatcaaatg ttcaatgacc ttatgttcat tttcattcag 1814341 caggttcttt tgaattttcg aatgaatggg tttattcata tgctgatcca agatatcggc 1814401 cgtttcttta tccccggcaa taaccattcg ttcccatctt ttcgcggcag ctttttgatc 1814461 aaggctggca gccagccgct tatacagtct cgattggttc tctgttacat gttccctcat 1814521 ccggttctct tcaaatggtg gcgctttgtc tacagcggaa tggctattct tccaagactc 1814581 attgatcata tcatactcat aacgctccac cgcctcaatt tttcctaaaa cagtttcaat 1814641 aattttcact tcatgctgct gagttaaaat aaacgccgta cttgggtatg tctggcgcaa 1814701 accctttagc tgatccagga cagctgtttc ttcccagtaa aatcttgtat ctacagggac 1814761 ttgaagctta ataggttccc atatgccgct gtcggaaaca aaaaacacga gactgcgggg 1814821 catgtctttt cccattgcat tcaagtattg attcatttta gccctgattc catccagaca 1814881 cttttcctcc tctggatcac tagctgccaa atactctttt aatcggctga atcctgactt 1814941 tagggcaatc ttccattctc ccccctgctg ctctggatct ctcatgtctg tattgagata 1815001 cagagagaga attttatccg gcggttccaa ttggacatac tgtaatttgt taatcaatga 1815061 atcaatcgcc attccgattc ctcctttttc acaggttagt tttctttttc ctctcttaaa 1815121 aacgatcaaa cctgactttc cgctaatttc tagtaataat ggaattgttg tttacaatac 1815181 gcctctcttc taatacaatt ggtaactgtg tttctaagct gttttttgaa aggagtttga 1815241 tcttgtttac tgttaaagaa aaaaatcgtc aagagcttga ggaagaacta aatgatttag 1815301 aatttcaaat ttatcgcatg caggagaata tgaaggattt atctaaagat gccaaagtgc 1815361 ttggtattga tcaatcgaaa catgatgagt ggatgattgt ttcctcgatt gatgatggcc 1815421 aaacatgcaa aattatgcta actgattgta aaacggcata ccgaggaaaa ggctgttttt 1815481 cacttgtagc gtcttacaag gacgatgcca ttcatatagg ggatataaaa ggccctccga 1815541 atcacgggtt tggctccatt tgcatgaaat atttaaaaga tattgcaaga gaccataata 1815601 taccgaaagt caccggagac atcgccaaac gggattggaa tcatgtagac cggctgattc 1815661 acttttatga aaaacatcac ttcaaagtat gtatcgatca tgatacccaa tccggcagca 1815721 ttaagtgggt tgatttgtaa aaaagtctgg aagaaagagc caagatatgc tgtaatggta 1815781 taaaaccatt gatggagggt tctatgtacg cctcaaaact gaaaaaggga gacgaaatcc 1815841 ggatcgtgtc tcccgcgacc agcatgtcta tattatcaaa tgaagcaaaa atccaagcaa 1815901 aaacggcgtt agaacgctta ggttatcggg taaccatcgc tgaacacgca aatgaatgta 1815961 acgaatttga ttcatcctct atcgagtcaa gagtccatga tctgcacgct gccttttttg 1816021 atccaggcgt caaagcgatt ttaacgacac tcggagggtt taattcaaat cagctgctgc 1816081 gttatcttga ttacgagaaa atcaaacgac atccaaaaat tctgtgcggt tattccgata 1816141 taaccgctct ttgcaacgct atttatcaaa aaacgggtct tgttacgtat tcaggtcccc 1816201 acttctcaac atttgcaatg aaaaaaggac tcgattatac agaggagtat tttctttctt 1816261 gctgcgcttc agacgatccg tttgaaattc acccctcaag tgagtggagc gatgatcgct 1816321 ggtttttgga tcaagaaaac aggcgttttt atcctaataa cggccctgtt gtaatccaag 1816381 aaggttatgc ggaaggtact ttaattggcg gaaacttatg cacgcttaat ttgctgcagg 1816441 gaacggagta ttttcccgaa acagaacata ctattttatt gattgaagat gattatatgt 1816501 cagacatcca tatgtttgac cgcgatctgc aatcactcat ccacctcccc gctttttcac 1816561 atgtaaaggc gattttgatc ggcagatttc agaaagcatc aaacgtatca atagatcttg 1816621 taaaagccat gatcgaaaca aaaaaagaat tatccggcat cccgatcatc gcaaatataa 1816681 atgccggaca tacctcgcca attgccacgt tccctatagg aggaacatgc aggattgaag 1816741 ctatttcggg tacatcacga atatggattg ataaacatta atcagcttgt aaattttttt 1816801 acaagctttt ttagcgcaat cggctatgca tgccgcacga gacatgacaa atgtcatata 1816861 ggaggcatga tgtgtgctac tacaaaagac ttctctcatt agcgtatact gaaccgagac 1816921 acacaatgag aggatactta ctatgactga acaaaccatt gcacataaac aaaaacagct 1816981 gacaaagcaa gtcgctgcat ttgctcagcc tgaaacaaaa aacagcctga ttcagctttt 1817041 aaacacgttt atcccattct tcggcctatg gtttcttgct tatctcagcc tcgatgtctc 1817101 ctatcttctt acgttagcat taacggtgat tgccgcaggt tttctgacaa gaatttttat 1817161 catcttccat gactgctgcc atcaatcttt tttcaaacaa aaacgctata accacattct 1817221 cggttttctg acaggtgtcc tgactttatt cccgtatctt caatggcagc acagccattc 1817281 gattcatcat gcaactagca gcaatctgga taaacgcgga acaggagaca tctggatgtt 1817341 aacagtaaac gaatataaag ctgcatccag acgaacaaag cttgcataca gactttatag 1817401 aaacccgttt atcatgttta ttctcggacc gatttatgtt tttctgatca cgaaccgttt 1817461 taacaaaaaa ggcgcaagac gcaaggaacg tgtaaacaca taccttacga atctggcaat 1817521 tgtcgcgttg gctgccgctt gctgtctgat ctttggctgg caatcgtttt tactggtgca 1817581 aggcccgata tttctgattt caggttcaat cggtgtttgg ctgttttatg tgcagcatac 1817641 ctttgaagat tcttattttg aagcggatga aaactggagc tacgttcagg ctgctgttga 1817701 aggcagctca ttttataaac tcccgaaact gcttcaatgg ctaacaggca atattggtta 1817761 ccaccacgtt catcatttga gtccaaaggt gcctaactat aagcttgaag ttgctcatga 1817821 acatcacgaa ccattaaaaa acgtaccgac aatcacctta aaaacaagcc tgcaatcact 1817881 tgcgttccgt ctatgggatg aagataacaa acagtttgtg tcatttcggg ctataaaaca 1817941 tatacctgta agccttccgc ctgattcacc agaaaaacag aagctgcgga agaatgcctg 1818001 atgataaagg aggtcttcta atatactaga aggcttcctt tttattgttg gagggtgcat 1818061 tctggctttc acaatgataa agttacaagt aagatgaaaa gctgaaaatg aggtaagatc 1818121 atgattaaaa atcattttac atttcaaaaa ctaaacggga ttacgcccta tatatggacg 1818181 atatttttca tcctcccctt ctactttata tggaaatcat catctacatt tgttattatt 1818241 gtcggcatca ttttgacgct tttatttttt tcggtatatc gatttgcttt tgtctcaaaa 1818301 ggctggacca tttatttgtg gggattttta ttaattggca tttcaaccgc ctccattact 1818361 ctgttcagtt atatttattt tgctttcttt attgcttatt ttattggaaa cattaaggaa 1818421 cgcgtccctt ttcatatttt atattatgtc catttaataa gcgcggccgt cgcagccaat 1818481 ttcagtctcg tattaaaaaa ggaattcttt ctgacacaaa ttccttttgt cgttattacc 1818541 ctcatcagcg caattttatt gcccttcagt ataaaaagcc gcaaggagcg cgaacgactt 1818601 gaagaaaagc tcgaggatgc aaatgaacgg attgcagaac tggtaaaatt agaagaacgt 1818661 cagcgaattg cccgcgatct ccatgatacg cttgggcaaa agctttctct tattggttta 1818721 aaaagcgact tagcaagaaa attgatatac aaagatcccg aacaagcagc tcgtgaactg 1818781 aaaagtgttc agcaaacagc gcgaacttct ttaaatgaag taagaaaaat cgtttcctct 1818841 atgaagggca tccggctcaa ggatgaattg atcaacatca aacaaattct cgaagcagct 1818901 gacattatgt ttatctatga agaagagaaa tggcccgaga atatctcatt gctgaatgaa 1818961 aacattttga gcatgtgctt aaaggaagct gtcacaaatg tcgtcaaaca cagccaggct 1819021 aaaacttgcc gagttgacat tcagcagctc tggaaggaag ttgtgattac agtgtctgac 1819081 gatggaacat tcaaaggaga agaaaattcc ttttcaaaag gacatggctt actcgggatg 1819141 agagaacggc ttgagtttgc aaacggaagc cttcacatcg ataccgaaaa cgggaccaag 1819201 cttaccatgg caattcctaa taattcaaaa taaacataaa ggatggctta tatgattagt 1819261 atatttattg cagaagatca gcaaatgctg ctgggcgctt taggatcact tctaaacctc 1819321 gaagacgata tggaagtcgt aggcaaaggt acaaccggcc aagatgctgt tgattttgtc 1819381 aaaaaacgcc agcctgatgt atgtattatg gacattgaaa tgcccggaaa aacagggctt 1819441 gaagctgctg aggagctaaa agatacaggc tgcaaaatta tcatcttaac caccttcgcc 1819501 agacccggtt actttcagag agctattaaa gctggcgtta aaggctattt gttaaaagac 1819561 agtccgagtg aagagctggc caacgccatc cgtagcgtca tgaacggaaa acgcatctat 1819621 gcacctgaac tgatggagga cttatacagc gaagctaacc ctcttacaga tagagaaaaa 1819681 gaagtgctcg aacttgtggc tgacggtaaa aacacaaaag aaatcgctca ggaactcagc 1819741 atcaaaagcg ggacggtgcg gaattatatc tcaatgattc tagaaaagct tgaagtgaaa 1819801 aatcgaattg aagccattac ccggtcaaaa gaaaaaggct ggtttaaata aaaaaggatc 1819861 ttggcatctg ccaggatcct ttttgttaac ctgaaattcc cgtttgagaa cctcgtcgca 1819921 accagaatta aattgatcca tatcctcgct cctacgcccg ctgaacgatt gtttggttaa 1819981 cagcccaata aaagactgga ttgaatgata tccctgttaa aatggtcggc cattgcacat 1820041 cagcagaatt tctgatattg attatattgt attttcagta tgacaaagtt gtgccacttc 1820101 gctcccgaag ctgccatgcc caactgcaag agcctaatat cacaataaaa aaccgtctga 1820161 aatcaatccg attccgtaaa tggtatctgc tacatccaac tgcttattat ctgccaaaaa 1820221 caccagctcg tttcgctgat caaagatagt aacaaccagc tataaatgtc atgatgccga 1820281 atgtctctgt aatgtggaat caatctttta acccgagagc ccctgaatcg cacataaaga 1820341 aaaacgggac cactttcttt tatcagcata tgatataaac agctctaagc agaacaaaaa 1820401 aagacacaag ccaaaagctt atgtctttta tcacaatcta tattattagt ttaagacttt 1820461 aacacttaca gttttgacgc cccaattaga agcatcactt ttacttggta caaatacgtc 1820521 gattttattt cctttaatag cgccgccagt gtctgctgct gttgcttccc cgtagccttc 1820581 aacatagact ttagaaccta gcggaattac attaggatca accgcaataa ctttcgcgtt 1820641 cgggttctta tttaagtcaa tgcctgtagc tgtaacgccg gaaatgccgc cgtcgttagc 1820701 agtgtaagca gtagcagtaa ctgttagttc ttttgaagct tcttgattat ttgtatttga 1820761 ttgaacagcc ttctcctctg tgttaacaga agtttctgcc tcagcctttg tttcttgttt 1820821 aggttgctgt tgtacagctt cttgtttagg ttgctctttt tgcacagcct cttgttttgg 1820881 cgcagcttga ggtgcgtttg tttgcgcatt ctcagtagct gtgtttgctg ctgttgcctg 1820941 accttttact gaaagagttg atccagcata gatcatgtca gagcttaagt tattccaaac 1821001 tttcaggttg ttgactgtcg tgccgaattt ttgagcaatc ttagaaagcg tatctcccgc 1821061 tttaattgta tattgcccag tcgtggttgt ttcttctgaa gaaatggtca gtttttctcc 1821121 tgcaatgatt ttatcagaag ttaacttgtt ccattctttt aagtccttta ggttcactcc 1821181 atttttctga gagattcccc agagcgtatc acccttttgc accgtaattt cttttgcaga 1821241 agcgtgagct ccgaatgcag ttgttgaaag tgcagcaact gccacaaagg acataatcgt 1821301 cttcttcata agtaaatcct cccttgttag ctttttattg gcggctaaca ggtgatatcg 1821361 taacacacgt aaatgtcaaa tcaataacaa aaagatatga tttagattac agttccttta 1821421 catgaaggat ttctctctga tggaaagact tgctgaaccc ttgatataat aggcttcgca 1821481 ggtcttttta ttttgaggcg aaacagagaa aataaaatgt gttttttata gaaaaaaaga 1821541 ttgtttttct gtttttttag tctgtcatcc ttgcataagc ctgtatttct tgtaaaaaaa 1821601 gccggccgta ttttgctctt ttttgttctc cgactccttt tatagacaaa agttcatcat 1821661 catttacggg ctgttttcct gacatttctt ttaacgtttg gtcagagaaa acaacaaatg 1821721 gcggaacacc ctgctcagcc gcaatttctt tccgaaccat gcgcaatcgt tcaaatagct 1821781 cgtcattttc agtaatcgct gccgctttta acgcttcttt tctcgctact gataattctc 1821841 ctttcagcac attccttcct ttactgctga caaaaagagt cggaaacgtt ccgtctgaca 1821901 tcctgatgaa gtcgtcagaa ataagaaatt cgataaaatc actgatttcg ccaacggatt 1821961 ggtgttttaa tatcccgtat gttgaaaggt cggaaaagcc gttttcaaga acttttttat 1822021 ttttggagcc ggcaagcacc tgggcaacca tcgtcttgcc aaaccgttct ttcatgcgaa 1822081 tgatacaaga taagaccatt tgcgcctccc gcgtcacgtc atgggccgct cttgtatcgg 1822141 tacagtttcc gcactgtccg cacgcatcag gctccttttc tccgaaatac ataaggataa 1822201 aacgctgcag acaatcttcc gtatgacagt agtcgaccat ttgtctcagc ttttttaaat 1822261 cctgcttttg tttctcttca tgttctgatt gctcaattaa gaagcgctgc accataatat 1822321 cctgcggtga aaacaggaga acacattcac tggcaagacc gtcccgtcca gctcgtcctg 1822381 cctcttgata atagctttcc atatctttcg ggatttgtgc atgcagaaca aatctgatat 1822441 ttgatttatc aatacccatt ccaaaagcag aggttgccac catcacttga agctcatcat 1822501 taagaaatct ttcctgctgc tcttttctca catcatcagc caaacctcca tgataccggc 1822561 ctgccctgac ctgatttcgt ttcaatctct catatatccg atcagcttct tttctggtcg 1822621 ctgtatagac aattcctgct tcatgcctgt tgttttgcac atattcgtct ataaaccgat 1822681 ctttattttc tccttttact actttaaagg ttaaattctc tcgggaaaat ccggtatata 1822741 ccgtgttttc tttttgaata tgcagctgtt tgcaaatatc atcatgaacc tcgggtgtgg 1822801 ctgttgctgt taacgccatg atgacaggct tgtcgtgtaa ttcacggaac aagatttcaa 1822861 tattcctgta gcttggcctg aaatcatggc cccattgaga aatacaatgc gcctcgtcta 1822921 ttgcgaccaa aggaacatct atgccctgca aaatccggat aaactctatg gacgttagtc 1822981 gctctggtgt aatgtaaaaa agcttataag ccccttcttt gagtccgttc agcctctcat 1823041 atatttcctg attggattgt gtgctgttaa tgtaggcggc gttaatcccc gcttcttcta 1823101 acgcatcaac ttgatccttc atcaaggaaa tcaacggtga aatgacgatc gtcgtccctt 1823161 caaacattaa tgccggaatc tgatagcaaa tcgatttgcc gcctcccgtc ggcataatgc 1823221 aggccgtatt ttgcctcgct tccgtcacca agcggatcgc ttcatcttgg ccgctccgaa 1823281 acttctcata accaaaataa tgagccagaa gggattgggc tctatgtaac ataacgtgta 1823341 aacctcgctt ttccttgaat ttctcccatc atatcataaa aaagcggcct tcatttcttt 1823401 cacacaaaaa tggaatattc actataccaa acctttttag ataaaataaa aagccatttc 1823461 cgaaaaggaa atggctttcg ctacgtcttg ccgtatgcaa gtaagaaagt tttaaaccac 1823521 cactcctcaa agtgggtgtt tgcagaaacg ttcctgtcgt cctctgcaat ggaggcatga 1823581 cattccggct tcgatataaa actccctatt acagcttaaa ggttaaaact taattaacaa 1823641 tacgcacaaa gtagcttctt taatatagta caccatcagg cgcttttaat caagaggtca 1823701 gaacaattgt ttagaaaaac tttttccagt gaataaaact gttttttctc caaaatacct 1823761 gacaattcga caaacaaaaa atatattaca ataaaaaaaa tagcctttat tgctaaaagc 1823821 gaatgattat tttcttctat attaatgtgt atatacaaaa agactcctat ttgtaacgat 1823881 aggagtcttg gctttattag aattttgcag caagatcttt tgcttcttgt aaaccttttt 1823941 caacgatttc ttgcgcttga tcaggtgctg cgttatgtcc ttcgatgaca actgtgtgca 1824001 agtcttgaac accccagaaa ccaagaactg ttttcatgaa gtttaatgac atttcaagtg 1824061 cagccattgg tccttctgag tagacaccgc cgcgagcgtt aagaagcgca acttttttgc 1824121 cgcccattaa accgactggt ccttcttgtg tgtatttgaa tgtaacgcct gcgcgagaca 1824181 gataatcaac ataagtatga agcactgctg gcactgtgaa gttccaaagc gggaatgcga 1824241 aaacaacttt gtcagctttt acaaactggt tcagatattt gtcagcaatt gctgcttgtt 1824301 ttttctcatc ttctgtcatt tccattcctt gacctgcttt aaatgttccg ttaatcatat 1824361 ctctgccaag gtaaggaagg ttttccttat gaagatctaa ttcaaccact tcatcattag 1824421 ggttgttttc tttataagca gctaagaaag cttcgtaaag tttagttgaa acgccttctt 1824481 cagctgtacg gtcgcttgat tttacaaata aaactgtaga catttgtatt cctcccggta 1824541 aactttttat atttacttac aaatagtatg ttactttctt ttttacgtaa agtcaatcac 1824601 tttattttga atatgagatt ttttttcaaa aaaaagcaag tacatctaat atcggtgtac 1824661 ttgcttggca tttttacttc gaatcttgtt cacgatccaa gatttcatac gtctgcgagc 1824721 ttttttgatc aattgtttct ttgttggata agtcttttac ctgttcatga aactctcttt 1824781 cataagaagg agcatctgtc tccagatcat cctccacatc agcttgggcc tcaactgtca 1824841 ttcttgcata aggaacagct tcaagtcttt cgtaaggaat ctcttggccg gttttttcac 1824901 acacgccata agttccgtct ttcatctttt gtaatgcacg gttgacctcc tctaacagct 1824961 cccggtcaat ctctttcact gtttggtctg tcatccggtc tgtgacgagc gtcccgtggt 1825021 ctgccatatg gttgtcaacc ccattggaaa gctcccccac ttcttccgtc attgattctg 1825081 tttccttttt ctcgccagac aattcttttt gcatatcgag caatttatga tagagatgct 1825141 gtgtttgttc ttttgtcagt gccatgtata tcctctcctt tctatcctgt ttcccgtttt 1825201 gccttctgtc aaacatggaa acatcgatgg aaagatgagc tactgccttt ttgaacggat 1825261 cgtgaccgct ggcgtcgatg gtgcttcggg ttttcgttgg cactttttgt ccttctcttc 1825321 tggcggtata taataggttg cgcctatatt taatctgccg ctcagttcat caatggtcag 1825381 ctcgccgaat tcaagatgat agtcaacttt ttcgacattc agcgtttcaa tatgtatata 1825441 ggtttcttca gactcttgtt tgctgctttg tttttgtttc tcaatcactg agagtctttc 1825501 ttcacattca cgcagtttgt caagttctgg tttcaagcaa tgcctgatca gcgaccggaa 1825561 catttttttc atgacatcac gaccctttgc atactcctct ttcgtctaca tatataatga 1825621 ggtatatccc atagaaagga gaggttttca tgcttccgac taacatcaat atttctcatc 1825681 tcaagactaa ctcgataggc accggctcat cccttacctt tggttctgcg gagttaagga 1825741 acaggtgctc tgctatcaaa agaaataacg gttttgggga acaaaatgca gatggtattg 1825801 ttatggtcat tccgattgaa tcaattgatg accgtgatgt gtcagatgca ctcagtatga 1825861 aaatcaatca tcaataacaa tggttttcgc ttgaccttcg tctttttgaa tagtgatgta 1825921 taggattccg tctttaaaaa tggcattcat ctttccatga agatgatcgg aaagcggaat 1825981 tttcttttca aaacttccgt atttcccttc tttttggcga aagtcctgtt cattaaaata 1826041 ggaaaagcgc tgccccttca ccactaaata atctccgtac gataatatgt gaacgtcttg 1826101 tttacggtag cctggaagat aaattaaaaa ctgcacttcc gcaacggtat ctacaatatc 1826161 catgctcgga aatgaagcat ctcctttccc tcgctgatct tgctgcgcaa acggaaacgg 1826221 agattggcca tttgtcataa aaggggtttt ttggtcttca tcaaatacct gtttccaaaa 1826281 gtcaccgccg tacatctgct gtgcgaattc catccactgc ttcatctttt cgaaatccat 1826341 ttgaagcccc ctgtcttaac atactttata accgccagca tacaactata gaaaggaggt 1826401 ttgcctgtgg ttcaaccaac tccgtatatc aatattaata ttttcatgct gaaaattaat 1826461 tcctttgaaa atgcttcagc ggttaacgta ggacaaaatt tattggcaga atggcaaaat 1826521 tcagataaaa aaaatcaagg ctacggacag aattttggag atgcgagcgg atttatgggc 1826581 acgagaagcc atgtggatga cagagaccaa attgattctc cggcctcttt tgaaagtgaa 1826641 gcggttaact cctcaatcaa aaggaagtga tgagatgttc ttttcaccct ccgtcgtaaa 1826701 tgtcggcgga tttaaaatca atacgatgga tcgaggttcc tctttaacac tcggtccgta 1826761 tcagcaggtc gattactttt tatcagctaa aataaatcaa gggtttggag aagaaaatgg 1826821 cgactttact cctcttgtcg tgccgatttc aaatgtatta gatgcagatc ttgttgattc 1826881 gaactcagcg aaaaacagtg tggtgtaata agaacagggc gcacatgccc tgttcttgtt 1826941 tttatatata aaaaaagcct aaccattttt tgaacggctg gctcatcaaa tattcagctg 1827001 cacaaatgct ttgtcagcac cgcctgaacc tcgcttaaat cggtgtcttt cgcaaattct 1827061 aattcgaaag ttttgcttct tgtcatcaat aaaagcccag tgtccggatc aaacattccc 1827121 gcttcttgga tggcaaagct ttcaattgtt ttatatggaa gaaatacacg aaccttcttt 1827181 ttagaaaaca ttttattgtc aaagaaaatg atccgcttat ttgtaaagca aatttggtcc 1827241 actcggagct tataaatcga ttcaattctt tccccttcaa cgagcaaagc ctcaagcttc 1827301 tttgcgtccg ttgatctgct aacagaaaaa atacccaatg aagaacccct ctttctgcat 1827361 ttatctattt gttttatcat tcactacata aaaataagtc ctttatccct atataagaat 1827421 acgacataga agacatttaa accattacga acagattaca tttttcaaat ttttgatttg 1827481 ttttttggct tttaagctgt tgtcatcaag taatacgcac atatagagaa aaaagtttca 1827541 atattcagca atgtttttat aaaaaagtgg tttttaatga tttttttaat tttgttttat 1827601 atttcctgtt ttaaccacaa aaaaaccgca gctgagctgc ggttttatgt atcgactgct 1827661 tttaacaaaa tctgtttgat gcttcaagga agcattacat ctcttcgaag tattctttat 1827721 aatagccgcc gactttattc gtattgtcga ccacaaagag aaactcctct gtttcatttt 1827781 ttacttcata ttcttttccc ggcgttaaaa cgcggtttac gatatatttt tttgcgtttg 1827841 tctgcacaca ctttactttt ttaatggttt ctttttcaag ccaattttta tgaatcatga 1827901 tgaaatctcc ttttcttatc tataagctta ttgtagcttt tttcttttgt aaattgcaat 1827961 atcggttatt cattgatttt gccttgattt ctattataga atgtttgtat acgcttacgt 1828021 ttgaagcaac tatcacagct tatttctgct attcaatcca ggaatcaatg tgctatcacc 1828081 aagaatctca gaacagacca taaaaaatga ctggaggttt gttacggatg agttctttaa 1828141 cgatgcaagt gacgaaaagg ctggagacat ttttacaggg aacaaagaag ctttatattg 1828201 acggaaagtt tgttccgagt gcctcagggg caacctttga cactccaaac ccggcgaccg 1828261 gcgaaacctt gatgacgctg tatgaagccc aggctgcgga tgtggacaaa gctgttaaag 1828321 ctgcccggaa agcctttgac caaggtgaat ggagaacaat gtctccagct tcgagaagca 1828381 gactgatgta taagctggca gacttaatgg aagagcataa aactgagctt gctcagcttg 1828441 aaacacttga taatgggaaa ccgatcaatg aaacgactaa tggagatatt ccgctggcta 1828501 ttgagcatat gcgctattac gccggctggt gtacaaaaat aacaggacag acgattccgg 1828561 tttccggcgc ttattttaat tatacgcgtc atgagcctgt cggtgtcgtc ggccagatca 1828621 ttccatggaa tttcccgctc ctgatggcga tgtggaaaat gggcgcggca cttgcaacag 1828681 gctgtacaat cgtcctcaaa ccggctgaac aaacaccgct ttcagctctt tatttggcag 1828741 aattaattga ccaagccggt ttccctgccg gtgtaatcaa catcatccca ggattcggtg 1828801 aagatgcggg agaagcgctg acgaaccacg aagcggttga taaaattgcc tttaccggtt 1828861 ccactgaaat cggaaagaaa atcatgtcca ccgcagcgaa aagcattaag cgtgtgacat 1828921 tggagctggg cggaaaatcg cctaatattc ttctgccgga tgcgaattta aaaaaagcca 1828981 tcccgggcgc tttaaacggt gtgatgttta accagggcca agtctgctgt gcgggctcac 1829041 gtgtcttcat tcataaagac caatatgatg aagttgttga tgaaatggca tcctatgctg 1829101 agtcactccg ccaaggagcg ggacttcata aagatactca aatcgggcct ctcgtaagca 1829161 aggaacagca tgagcgcgtt ctttcctata ttcaaaaagg aaaagatgaa ggagcaaaag 1829221 cagtgaccgg cggaagctgt ccttttgaag caggatattt tgtcgcaccg actgtgtttg 1829281 cgaatgttga agacgaaatg accatcgcaa aagaagaaat tttcggaccc gtgctgactg 1829341 caattccgta cgaaacagtc gatgaagtta ttgaacgggc aaaccattca gaatatgggc 1829401 ttgcagccgg actatggaca gagaacgtca agcaggctca ctatatcgcg gaccgacttc 1829461 aagccggaac cgtttgggtc aactgctata atgtgtttga cgcggcgtct ccatttggcg 1829521 gttataaaca gtcaggactc ggacgagaaa tgggatcata tgccttggat aattacacag 1829581 aagtcaaaag tgtatgggta aaccttgaag actaacatgt atgtttaaaa aactgctgcc 1829641 tgccagcagt ttttttcttt ctgtaatggc agtaaaagac gctgaatata tatgcttctg 1829701 aaggagttga gcgtgatggg cacacttcag gagaaagtga ggcgttttca aaagaaaacc 1829761 attaccgagt taagagacag gcaaaatgct gatggttcat ggacattttg ctttgaagga 1829821 ccaatcatga caaattcctt ttttattttg ctccttacct cactagatga aggcgaaaat 1829881 gaaaaagaac tgatatcatc ccttgcagcc ggcattcatg caaaacagca gccagacggc 1829941 acatttatca actatcccga tgaaacgcgc ggaaatctaa cggctaccgt ccaaggatat 1830001 gtcgggatgc tggcttcagg atgttttcac agaactgagc cgcacatgaa gaaagctgaa 1830061 caatttatca tctcacatgg cggtttgaga catgttcatt ttatgacaaa atggatgctt 1830121 gccgcgaacg ggctttatcc ttggcctgct ttgtatttac cattatcact catggcgctc 1830181 cccccaacat tgccgattca tttctatcag ttcagctcat atgcccgtat tcattttgct 1830241 cctatggctg taacactcaa tcagcgattt gtccttatta accgcaatat ttcatctctt 1830301 caccatctcg atccgcacat gacaaaaaat cctttcactt ggcttcggtc tgatgctttc 1830361 gaagaaagag atctcacgtc tattttgtta cattggaaac gcgtttttca tgcaccattt 1830421 gcttttcagc agctgggcct acagacagct aaaacgtata tgctggaccg gattgaaaaa 1830481 gatggaacat tatacagcta tgcgagcgca accatatata tggtttacag ccttctgtca 1830541 cttggtgtgt cacgctattc tcctattatc aggagggcga ttaccggcat taaatcactg 1830601 gtgactaaat gcaacgggat tccttatctg gaaaactcta cttcaactgt ttgggataca 1830661 gctttaataa gctatgccct tcaaaaaaat ggtgtgaccg aaacggatgg ctctgttaca 1830721 aaagcagccg actttttgct agaacgccag cataccaaaa tagcagattg gtctgtcaaa 1830781 aatccaaatt cagttcctgg cggctggggg ttttcaaaca ttaatacaaa taaccctgac 1830841 tgtgacgaca ctacagccgt tttaaaggcg attccccgca atcattctcc tgcagcatgg 1830901 gagcgggggg tatcttggct tttatcgatg caaaacaatg acggcggatt ttctgctttc 1830961 gaaaaaaatg tgaaccatcc actgatccgc cttctgccgc ttgaatccgc cgaggacgct 1831021 gcagttgacc cttcaaccgc cgacctcacc ggacgtgtac tgcacttttt aggcgagaaa 1831081 gttggcttca cagaaaaaca tcaacatatt caacgcgcag tgaagtggct tttcgaacat 1831141 caggaacaaa atgggtcttg gtacggcaga tggggtgttt gctacattta cggcacttgg 1831201 gctgctctta ctggtatgca tgcatgcggg gttgaccgaa agcatcccgg tatacaaaag 1831261 gctctgcgtt ggctcaaatc catacaaaat gatgacggaa gctggggaga atcctgcaaa 1831321 agcgccgaaa tcaaaacata tgtaccgctt catagaggaa ccattgtaca aacggcctgg 1831381 gctttagacg ctttgctcac atatgaaaat tccgaacatc cgtctgttgt gaaaggcatg 1831441 caatacctta ccgacagcag ttcgcatagc gccgatagcc tcgcgtatcc agcagggatc 1831501 ggattgccga agcaatttta tattcgctat cacagttatc catatgtatt ctctttgctg 1831561 gctgtcggga agtatttaga ttctattgaa aaggagacag caaatgaaac gtgaatctta 1831621 tcaagcggag atgttcaatt ggtgtgaagc cctgaaagat cagattcaaa agcgaggtca 1831681 gcttgaccag tttgaagatc aaatcgacaa gatgattgag gctctggaag atgaccaaac 1831741 aacagaagaa gattggtata aacaggccgc tgccctttat cgggatatta cagaatcaga 1831801 tgatacaagt gaaagacgcg cttatgtccc tatagggaaa cacgtgctgc caaagcttcc 1831861 ttacaaatac tccgccttag aaccttatat atcacgcgat attatgatcc ttcatcatac 1831921 aaaacatcat caaagctatg tcgatggcct gaacaaagca gaatcagagc ttaaaaaagc 1831981 gagagcgaca aagaattatg acttaatcac tcattgggaa agagagcttg cgttccatgg 1832041 agcaggccat tatttgcata gtattttttg gttttctatg catccaaacg gaaaacggcg 1832101 tcctacaggg gcattgttcc aaatgataga cctttcattt ggaagctatt ccgcttttaa 1832161 agaacatttt acccaggcct ctaaaaaagt ggaaggcgtc ggctgggcca ttctggtctg 1832221 ggcacctcga tcaggacggc tggagatttt aacggcagaa aaacaccagc tctttagcca 1832281 atgggatgtg atcccccttt taccgcttga cgtatgggag catgcctact atttgcaata 1832341 caaaaatgac cgggccagct atgtcgatca ctggtggaat gtcgtggatt ggcgcgaggc 1832401 tgaaaaacgt tttgagcagg caaaagaagt cgtttggaag ctctattaaa aaaagccccc 1832461 tttcctcggg ggcttcgtgt gttaaaaaat acctatcaca tgcaaaaaca cgatgatgat 1832521 ggcaacagga gatagatatc gaatgagcag cagccaaacc gcaaaccact ttcgtttgag 1832581 attggaaccg cttttcagct cgtcaaacaa atcctgtttc ggtattttta gcggaacaaa 1832641 aatcgaaatc agtaacgcac ctaacggcat taaaatattg ctcacaagat agtcagccgc 1832701 atcaaaaata gacagatgaa atatagtgac gtcacttaag acaccgtatg ataatgcaga 1832761 cggcacaccg acaataaaaa tagcaatacc gcctaaccaa gcgaatcgtt ttctcttatt 1832821 gatatcgcct ttcgacagta ctgcgaccaa aatttccagc attgaaaaag cagatgtcaa 1832881 tgcagcaaat aaaaatagaa gtaaaaatgc taataaaaag ataattccga acggcatttg 1832941 attaaacaca gtcggcagaa cgttaaataa cagaaccggg ccttggtctg gcttgaggcc 1833001 gaatgaaaat acagctggaa aaatcgcaat tccggccatt acagcaacaa gcatgttcat 1833061 aacagttaca gatacagcgg actgtaccag attttcctgt ttctctaaat aagcgctata 1833121 cgttaccatg acagatacac cgacacttaa taagaaaaag gattgtccca ttgcatataa 1833181 aatggtattg gcatcaattg cagttaaatc aggcatgagg aaaaatttga ttccttccat 1833241 cgcgccatca agtgtaaccg aacgcaccat taaaatgatg aataatagaa aaagcgccgg 1833301 cattaatact tggcttgctt tttcaattcc gctgcttacc ccttttgcaa caactaaaat 1833361 tgttaccacc ataaagagca gctggcctcc tacagccaaa taaggatttg aaatggtact 1833421 tgcaaatatc gtatcaaaac cagatgtttg cgataaaccg ccagtgaagc cttttataat 1833481 ataaattaaa atccatccgc ctacgacact gtagaaagat agaagaataa agcacgtcac 1833541 catgcctaaa taaccgatcc aatgccactt cgttcctgga gcaagtgttt tataggactg 1833601 aacggcatct ttctgtgttc ttctgcctat gatgaattca cctaacaata aaggcagtcc 1833661 gattaaaacc gtaaataaaa taaaaataag taaaaatgcg cctcctccgc tggttccggc 1833721 aacatatggg aatttccata tcgcaccaag cccgatagct gatcctgccg cggctaaaat 1833781 aaagccgagc ttcgaagacc attgatttgc ttccttcacc gtatcactcc tatttgatct 1833841 aaccattata aaggttcatt gtaagaatat cttcctatat agtcaagaac attttaatta 1833901 gtttacatca tatatctata gacatctgcc aaaaactaat attgaattat tcagaaaatt 1833961 atttataata agagaatgtt atgaaatttg taagaatttc tgctgaagtt cttgataagt 1834021 gtgttaggag tgtttttatg gacatcatta gaaaaataag ccattttgca ggacaaacct 1834081 ttggcatatg ggtcattgtt tttgcagtgc tgggattttc tttcccatct ttatttacgt 1834141 ggatcagttc ttatattacg atttttctcg gcattatcat gtttgggatg ggccttacac 1834201 tgcaagccga tgatttcaaa gagctggtca gaaagccttg gcaagttatt attggagtaa 1834261 tagctcagta tacgatcatg ccgctcgttg ctttcggcct cgcatttggg cttcatcttc 1834321 cagctgaaat cgcagttggt gttattcttg tcggctgctg tcccggggga actgcatcta 1834381 atgttatgac attcttagca aaaggaaata ctgccctttc tgttgcggtt acgacaattt 1834441 ctaccttatt ggcacctgtt gtaacaccgt tgttgattat gctgtttgcc aaagaatggc 1834501 ttcctgtctc gccggggtct ttgtttatct caatcttaca ggcggtttta tttccgatca 1834561 ttgcaggtct gattgtcaaa atgtttttca gaaaacaagt ggcaaaagcc gtacatgccc 1834621 ttccgcttgt ttctgtcatt ggcatcgttg cgattgtctc agctgtcgtc agcggcaatc 1834681 gggaaaatct gcttcaatcg gggttgctca ttttttcagt tgttatcctg cataacggta 1834741 tcggttattt actggggttt ctttgtgcaa agcttttaaa aatggattac ccgtctcaaa 1834801 aagcgattgc aatcgaagtc ggcatgcaaa actccgggct tggggctgca cttgccacgg 1834861 ctcatttctc accgctatct gccgtaccaa gcgcaatatt cagtgtgtgg cataaccttt 1834921 caggttctat gcttgcaaca tattggtcaa aaaaagtgaa aaagaagcaa gctggatcca 1834981 aaagcagcaa tctatcactt taaatatgca tcaaaaaggg tacatcactt tatcgtgatg 1835041 tacccttttt tattatcctt ctaataaaag ctgttcagga tcttccagta aatttttgat 1835101 tgtcacgagg aaaccaaccg cttctttacc gtctacaatt cggtgatcat aagataaagc 1835161 gatatacatc atcggacggt tttcgaaacg ctcttcatca atggctacag ggcgcagctg 1835221 aatcttatgc atgcccagta taccgacttg cgggctgttt aaaattggag ttgacatcaa 1835281 tgaaccgaaa gtccctccgt ttgtaatcgt gaaggagcct ccctgaagct cgctaagggt 1835341 taatttattg tttcttgctt ttttcgcaag ctcgccgatc tctttttcga ttcctgcaaa 1835401 tgtcaggcga tccgcatccc gtacaaccgg aacgacaaga ccttcatcag cagcaacagc 1835461 gattccgata tcgtagaatt ttttaacgat caactcatcg ccttgaattt ctgcattcaa 1835521 cagcggatat tttttcaatg cagccacgac cgctttcgtg aagaaagaca taaagccgag 1835581 cttcacttca ttttgctcaa aaaattgatc tttgcggcgt tttctgagat tcatgacagc 1835641 cgtcatgtcc acttcattaa atgtagtcag catcgctgat gtttgctgta cctctacaag 1835701 gcgttttgca atcgtttgtc tgcggcgtga cattttttgc acttcaacag gtttgtcaaa 1835761 gctttgctgt gctttttgag cctgaggctg ctgcttttgc tgaggagccg gttttgatgc 1835821 cggtttttcg tacgcttcga catcctgctt gcgcactctt ccaagcggat ctccagttgg 1835881 aacttgagac aggtcaattc ctttttctct cgcaagctta cgggccgacg gagaagcgat 1835941 cgttcttgat tttgcttcag attgtgcttc ctcgctcacc tcttgtgcag ctggttcagc 1836001 ctgtttctct tcttttacgc tttccttgct ttctgttttc tctgtaggag caggggcaga 1836061 actttcaccc gcgccttctg aaatcgtacc gataatttct ccgacctgga cggtatcacc 1836121 cgaatctttc aatacctctt gaagtacacc cgattcttct gctgtcaatt caacattcac 1836181 tttatccgtt tctagttcaa gcagatattc accctgttct acatagtcac caggctgctt 1836241 taaccattgg gctattgttc cttctgagat tgattctgct aattcaggta ccttaatttc 1836301 cgccattttt tcatttcccc cttagttttt gcgagtcaag ctatcagata caatacgttc 1836361 ctgttctttt ttatgaactg tcggatctcc ctctgcaggg ctggatcgtc ttcttcgtcc 1836421 aatatattga acgcttactc cctctggtgc aatctctgtc aaatacgggc tgatataacc 1836481 ccaagccccc atgttctgcg gctcttcctg cacccaaacg atttctttca ggttcggaag 1836541 ttttgcaaat aattctttga ctccttttgc cgggaatgga tacagctgtt cgattctcgc 1836601 aatgtgaagc cactctttac cgtcttctaa cttattaaaa tgatcgctaa tgtctataga 1836661 cactttaccg ctggataata caagtctggt tactttttca tagtcatgag aaagtcccga 1836721 ctgttcataa acaggctgga agcggctttc gctgagctcc tgcacttccg acaccgtatt 1836781 tgggttgcga agaaggctct tcggcgtcat aatgacgagc ggtctgattt cttcacgaag 1836841 cagcatttta gcctgtcttc ttaaaatatg gaaatactgt gccgcgcttg tcaggttggc 1836901 aaccgtccag ttgttttccg ctgcaagctg caggaatcgc tcaattcttc cgcttgagtg 1836961 ctcaggcccc tgtccctcgt aaccgtgcgg gagcagcatg actaatccgg atttttggcc 1837021 ccatttcgcg cgtccggcag aaataaattg gtcaaaatac acttgagcag cgttggcaaa 1837081 atctccgtac tgtgcttccc acaaaacaag cgtttccggt gaatgcacgt tatagccgta 1837141 ttcaaaaccg agaaccgatc cttcagacag cgggctgtta tgaacagcaa atgatgtgct 1837201 gcagtcagat aagtgatgaa gcggcacaaa ttctttgccc gtctcactgt catgaagcac 1837261 aaggtttctt tgggcgaacg ttccgcgctc ggaatcctgt cctgttaaac gaatcggtgt 1837321 tccgtctttc aaaattgaag caaacgcgag tgattctgcc aaagaccatt ccacttttct 1837381 gtcatcatcg aacgccttgg cgcgtctttc taaaatgcgc tttagcttgc cgaaaacatt 1837441 aaatgactcc ggccagttga tcaattcgcc attcagcttg cggagcacat caaaatcaat 1837501 cgaagtgtcc acatctggga aaccgtttga tacaggctct ggaagttcaa tttcacaagc 1837561 agtgtgttcc tttttagacg gaactttctg atatgcatcc tcaatgcgct tcgttaccga 1837621 tttttcgatg ttttgaacga cttcctcggt aaccacgcct tcttttacca gcttttcagc 1837681 gaaaatttgt ttgacggtcg gatgctttct gacagcatca tacagcattg gctgagtggt 1837741 tgacggttca tccatttcgt tgtgtccata gcgtctgtac ccgatcaaat caatcagaaa 1837801 atccttgttg aatgtttttc ggtattcgac cgcaaactta acagctgaaa gacaagcttc 1837861 aggatcgtcc gcattcacgt gaacaatcgg aatttcataa cccttggcca ggtcgctggc 1837921 atattttgtc gatctggatt cagcgctttc tgttgtgaat ccgatcatgt tattggcgat 1837981 aatatgaatc gcaccgccta cttgataccc ttttaaagag cttaaattca atgtttcagc 1838041 tacaattcct tccccaggga atgcagcgtc tccatggatt aaaatggcca gcgattttgt 1838101 ttcatcttgt accgggtatc cgctttgtgt tcgcgtttcc tgtgccgctc ttgtgctgcc 1838161 ttcaacaatc ggattgataa attccaagtg gctcgggttg ttcgctaacg taatgcgcgc 1838221 tgattttgtt tcagcgtctt gaagctcccg attcgccccc aaatggtatt tgacatcccc 1838281 cgtccatccg tagctgattc caatggatcc ctcagacggt acaagatctt tgttcggcgc 1838341 atgctggaat tcagagaaga tgatttcata cggtttgccg agcacatgtg ccaagacatt 1838401 caggcgtccc ctgtgcgcca tcccgatgtt gacacttgtc gtgcctgatt tgacagattg 1838461 tgcaataatg tcatcaagca ctggaacaag agcgtccaga ccctcaatgg aaaagcgctt 1838521 ctgcccgacg aatgtgcggt gcaaaaactg ctcaaagccc tctacttctg tcaatctttc 1838581 cagcacagct gacagctttt cagctgagtt cttctggaac agctcgccag attcaatctt 1838641 tcttgtcagc cactcgcgct ctttgaagtc atgcacatgg tcaaattcaa aagagatggt 1838701 tcttttatac gtatttcgta aatactgaat ggcttctaaa ccgttcgaaa tgtttttagg 1838761 agcgtctttg cagatgacag acgcaggtat tgcttttatt tcctcttctg ttagcccgta 1838821 atcggataat ggaaaaagtt cgctcttttt ctcatccttt ctgagcggat tgacggaagc 1838881 gttcaaatgg ccataggttc ggatatcttc tgcaagtctg actgcggatg cgatcttttg 1838941 aatcagatcg gctgtaacac gtcccttttc ttttgttccc gaggcctctt ttatatcgct 1839001 tggcggagca ccgagctcgt cgaacatttc cttcaaatcc gggtcaatgc tgttcggatc 1839061 ctgggtatac tgatcgtaaa gctccagcgc atagccgagg ttcggaccgt aaaaatcttc 1839121 ccaattcatt cgttgtttca tactattttg aaacatttga atattacccc caacttaaat 1839181 aatcaagtga ttgattcact atcttgaaat aactttcgaa cgctgtgtcc aaaattatgt 1839241 aataaaaacg cttccaacga tattttacca ctgtttgcaa tttgattcta ccttgattgt 1839301 tcacaaaata gtaaaaaacc tttataaaaa acaaaaaatt taatcattcg aaaaaacaaa 1839361 cgccaaaaag cataggatta agggctatcc tatgctttta tgaagcagtt ttttcagcag 1839421 cggatacaaa acatccggta gctgatcaac atccgggaca aatatactga attttccgta 1839481 catatcctgg atcgtcttca tttgcgattc ttctatttct gagttggaga gaaaaacatt 1839541 tatcacttct attcctcttt ttcgggcttc gataaccgcc tcacttgtat caacgatccc 1839601 attttgttcg tagccaaatg cggccggctc tccatctgag aaaacaatta agaacttttg 1839661 cgcctcgctg cgatgcagca tttttttcgt catctgccta attgcgtacc cgtcacggtt 1839721 atcttcttct ggctcaagct gcataatggc cggtccagaa tcttgtctta atgatgattg 1839781 gaagggaata accgtattga aatagtttgg ctggcttttt tcggttgcat catttgtgtc 1839841 ctcccaaaaa ccgacaatct gatgcggaac cgctaccgat ttcaacgctt cgtgaaacag 1839901 cacgattcct cgttttgttt cgtccatttt gtcgaacatg ctggcggaac aatcgaccag 1839961 caatgtaaaa actgcgtcga tttctgaaga tggttcttgc tttttgtaga acaggcgcgg 1840021 atttcgctca gtgaagtaac gaagaagctt attgttcagt ctcccggcat gaaggtctgt 1840081 tctcggcaat gtttttttat gctccagcgt tttttgaatc atttgtttca aacgcttttg 1840141 atacgattca atcgtttttg cctgctgttt ataagaaagc tcttcttcac tggttgccgg 1840201 ctgcggttct ttataaattg gaaatgcata tttattttct ttgccgtcag ccatacccgc 1840261 tccgttcggc tggtcttttt gggactccag cgcttccagc ttggaatagt ctttccgttt 1840321 cgtttgtctg gctgatcctt gaacagagcc aagggcctga tctccatcgt cgccttccct 1840381 tgaagcatct tttcctaaat ctgattttgc gccgtgttca atatcaaatt gaaggaagct 1840441 tttagacggt gcttctgttt cccggtgcca tgtcggcatt tcttcttcat ggatatcctc 1840501 atcaccgtct gattgttttg gaagcgtgat gtcatcactc agcttcggcg cttttttctc 1840561 ttcttcaaat aacggctgtt ctgcagcttt tgcgtaatca agctcaggca aaaagaagta 1840621 ggtgttcaac atgtctttat cgagtacctc ttcaagtccg tccatgaggt cctcaacaat 1840681 tttcagaacc tgccgtgtcg aatctgcttc atacacacgc aagagctgct gctcaataaa 1840741 cgggcgcatc agatcgatat cttcacgcat ggatggaagg gtctcgagcg gcgattccgc 1840801 tgtgagcttg aaatagatcg cgcaaaagag cgcatcggta aaaatgcttc gttccaaatt 1840861 taaggtcagc tgggttgaga aatgttttct gtacatgtct tttcgcttcg caaatacatg 1840921 tttcgtaccc gggcgctcac gtttgatgca ttcttcgatc ctaatgtctt caagcagcat 1840981 aaagagctgc ttggcaaaac ttttaaacgt aagatggcga tggatatcat tcaaaaagtt 1841041 cgcaaactca tgcagcgagc tatatcttgt tccgactgaa cgcaggtaga cgtcgctttt 1841101 cagacccgct tccatgtcct cagctgccct gtctttccaa aagtggctca tatagatttt 1841161 cttttcaaat ggattgtaat aggactgaac gccatactcc acttctaccg cttcactctt 1841221 ggtgagtgtt ttggccaaat cagtcagcat cataaataaa aatgaatcaa tcgtgctgtc 1841281 gttaaatttg ataaatttca tcgcagcccc ctcattcaaa cagagtttct gcaatatttc 1841341 ggacagccgc tttttcccga tcatcatcaa gcttttctac aattccccgc tcaatggcac 1841401 gacgcggcgg aatataagca gctaaatcac atgtatcgat taaagctctg atggatgccg 1841461 cttcttcaga cacctgtccg ttattggcct gaacgatcaa gtcagaggaa agcgtgataa 1841521 atctgtcaat caatttctcg tctttcaagg ctgactgaga catgagcact tgtttcagca 1841581 gctcgccttt aatataaggc acatcaatga tgacaaaacg gtttttcaac gcttcattca 1841641 gaggaacagt tccgacatag ccttcattga tggctgcaat gactccgaaa ccgcttttag 1841701 cccgtatgac ctcgcctgta aacggatttg tcatcatttt tctgtaatct aatacaccgt 1841761 ttagaatagg cagtgtttcc ggcttcgcca tattgatttc atctatataa agaaaatggc 1841821 cttccttcat tgcctttgta acaggtcctg aaacaaactc gattgttgcc tggccagatt 1841881 gattttcaat cgttttataa ccgaccaatg cctcagcgtc caagtcgact gaacagttga 1841941 cgctgtgcat cggtttatga aaatagctgg acaatgtttc tgccagcttt gtttttcctg 1842001 aacctgtagg ccctttcagc aggacatttt tccccatggc taatgcaata atggcgtcaa 1842061 ataaaatggc ttcatcctcc gcctcatagc ctgatgttcc tataagcgat tgaaactctg 1842121 gggaaatagg ctgctcttta tatgataaaa gcttttgttg tatatcttcc ggcaatgtta 1842181 agtgctgtag ttgagttgtc atagacagat tccctttcct attcatattc cattaacgag 1842241 tatactaaaa aagcccctgt atgctcaata caaaagggcc tggatgatat tactgcttct 1842301 cgttatttcc caaaagggct ccgcagacaa tacgcgcacc ggaattgccg cttgggtttg 1842361 tcagataatc gtccgcttgt tcatgaataa taaatgcact tccgtcctcg tcgagaatat 1842421 ttagtttact tccttttttc agtgaagtgt caggcgcatt cattatgaca tctacctttc 1842481 catcagcacc gacttcaagg ttcggcagat ctccggcatg atgccccatc ggattattaa 1842541 agccgtgttc tttgttcagt ggattaaagg gaccgcccgc tgattcaaaa tccggcctga 1842601 cacaagaacc tttctcataa atatgaaaac cgagagaagc acctggacgc aggctgtttg 1842661 cggaaatatg aatatcgagg ccttcatcat ctgattcttt gatctctata aaaccgactg 1842721 ctttcccttc acgattgacc agctggacat gatgaccaaa cgctgacgtt tcaaccactt 1842781 ttttttccgg cacccggtta ggagggtctg gaggtttttt ttgtccgcat ccggcaactc 1842841 ccagtgccgt cagcatcatc aacagcaaga gacggtgcat actgtctccc ccttgttttt 1842901 tctaacagtg tggtcaatca ttgtctggta taaacaaaaa agcctataaa aggctttttg 1842961 tcatactcat ttttaaaaat aacttcttgc gcccaagtac cgctgtttcc aatacgaatt 1843021 gctgagattg gaaatgtcga cgcccgatga gcttgcatga ataaaatcac cgccgcctag 1843081 ataaatcccc atgtgagacg ggccggattt atatgtggta aagaagacaa agtctcctac 1843141 tgacggctgg ctgactttct gcatgacatt ccaataccct gccgtactca atcttgatat 1843201 agatgataca ttattaatga ggtaataaat gaagccgctg caatcaaaac cggcaggcgt 1843261 gtttccgccc catcggtaag gcactccgac atattttttc gcttccgtta tcattctgtc 1843321 aatcttcgaa cctatttgaa tgtttgaccc tgagttatct tttggctttg ttggctttgt 1843381 cggatttgaa ggattagatt ttgatgctcc cgaaatagtc agaacctgcc cgatttgcaa 1843441 cacatccgat gataaattgt ttttatcacg gatgctttgg acagtgactc cgagccgatt 1843501 tgcaattttc cacagcgaat cgcctgcttt taccttgtac gtcgttgttt ttgagggatt 1843561 ggagtttgac ggctttttgg aaccgctgtt tccgttctta ggtgaactgc ttccttttat 1843621 tttgagcacc tgtttaggat aaagtgtatc tgatgttaag ccatttaagg tttttaattc 1843681 ggctacagtc atatttaagc tgtttgcgat tttccacagt gagtcaccaa gcttgaccgt 1843741 atatgtactt tttgaagaac ctgaagaatt ggaaccgctg tttttctttg atccatttga 1843801 tccgcttgaa ctgcttgtcc ctttgatctt aagcttttgc cccggacgaa tcaggtcact 1843861 gctcaggctg tttaagcttt taagctcaga aacactcatt ttatgatttt tagcaatcat 1843921 ccatagggaa tcaccatatg caactgtgta tgttgatgtt ttgcttgaat tagatgggga 1843981 tgtcgtgctt tttttgctgc tttcaggaac cttaagactt tgtccgacat aaagcaccgt 1844041 tgatttcaat ttgttttcgg atttcagagc tgatattgtc gtatcatact ggcgggaaag 1844101 tttccaaaga gagtcaccgc tttttacttt tatcgttttt gcttccgcgg gtgctgcggc 1844161 catcgacgac ccaacaactg cagaaacagc caagccggct acaatcttct ttttcattca 1844221 ttcaacctcc taaactgttt ttttgcaaaa acagctagta ttttgtttcc aaaaatggca 1844281 cacaactgtt ttatcgtcaa tttttcagca agttaaaccc ttttcaaaca tttggcgcag 1844341 cattttcagc atcgttcgac ctttaaacct tcaaataaac atctaacatt ttacataagc 1844401 acgatatgtt tttcgaaagt ctaaggaact atttaagcga gggtaaaaat gatggttttc 1844461 tattgatgaa cgaagcagtt tctcctcctt tcttgtctat ttttctaatc aattctctat 1844521 cggcgtgtca aatcccttcc tctgcattct tatgaaatgg caaaaagcct gttctttcga 1844581 taagaacagg cttttacact atgcatttgc tgattgagtt ttttgtttta cagcttcaag 1844641 aatgctgtcg gctgcttttt tagagccgcc tgccgctttc agtgattgtc caatttcttt 1844701 tgccttttca gcatacgaac gattattcat tacttcttgt atcgtctctt tcagtaggct 1844761 ttcagacaat tcttcctttt taattacttt tcctgcgccg actttttcta cctgatctgc 1844821 gacaacaaat tggtcgcctc ccatcggaat gacaacgagc ggggtttcaa aatacaaacc 1844881 ttcacttgtg ctgttcattc cgccgtgggt cacaaataag ctggctcttt tcaagatctc 1844941 aagctgaggg acatacgggc gtacaatgaa attctccgga atgtcgttta actcacttgt 1845001 tttaatatgc ttgccgatgg aaagcacaac tttaccgtca aagtccttac acacttcaag 1845061 gcattgatta aaaaactgct tttgattatt aaaaatggtt cccattgaaa taaacagcac 1845121 gttttcattg tcaatctgat caaatgggaa atcattgttt ccggctcttt ctgtaatgga 1845181 aggaccgaca aatacatatc gctcgccaaa ttgctcagcc agtggctgaa atccccttga 1845241 tgtaaagacg attgtcaagt caccatcagc taaaaaaaca tcaaatggct tcttgatctc 1845301 tgcttgaaaa tcagcattta acgtttctgc aagctgctgg tatgattcat aatgaggcga 1845361 atcttcaagt gatcctttca tgtacgctcc catcatttcc ttcgcaaatt cctcattcat 1845421 cgcaaaggtt gtacacaatg aaaatcttgg cagcttcagc atgttggcaa tgactttacc 1845481 cgcgagaaga tggtgatcat atatgacata atcatacgat tcatgtttga cttcctcata 1845541 aatatgagtc gcgatatcct tacaggcttt caaaaaagcg cagagcattt ctgtgaaatc 1845601 tctttcttca tcgccggttg cgtttttccc gaagtaatct cctctgaaat catgatactc 1845661 acgaaactct atatcaagag ctgtgatttt ttctttatat tccttcactg cgtagtacgt 1845721 aatgttttct ccccgggatt tcagctcctt catcacaccg atagagggat taatatgccc 1845781 ttcaccgggg aaaccgatca ttaatacatt agccatgcgg cagcaccctt cctttgagaa 1845841 tttatgtaat attttatacg gtactataaa tgcataaaca ggtaaagtat ttcacttaat 1845901 taatattcat catatataac ttttctacca gtttatattc cctgtcttca agacaaaaag 1845961 cattcagctt gaagcgaatg ctttaataaa gatgcgaatt cagtcatttt gtctcatgat 1846021 aggattctta atcaggccct ttttattatt tttacgttct tggtgaaatt aacggatata 1846081 atacaccgtc tttggcaaac gacatcttcc ctgtttcctc tgaaaccacg agcaccagtg 1846141 catccgtata gcccgacata ccaagagccg cccggtgccg ggttcccaaa tggatatcca 1846201 cttccttcgt cgtcagcggg agcacattgg ctgctgacac gagtttgttt tccctcacta 1846261 ataaagcgcc gtcatgaaga gggtttccgg gaaaaaagat gctttcaatt aatgaagagc 1846321 tgatctcggc gtgtagggag gtgccttttt gaataaaacg ttcaaccggg tctgctcttt 1846381 caatcacaat taaagctcca tgcttatgtt ccgataaggc tttaatcgcc ttggccagct 1846441 caataaatgc cggcgtaaat tcctcaatgt atgattgcaa ataaaaggag gatgcaatcc 1846501 cctgcatgtc ctgaaaaacg tgccccaaat catctaattc acaaaggaga cactggtctt 1846561 tttcgtgaag cgttttcaag attagagatg catcacctaa tatttgctct aagtacacct 1846621 gtattttccc cttgaacgca ttttctgata tctgctcata gcgcatagcc ttcatctcct 1846681 gtttaaattt ccaacttttc acgaatgctt atcttattga tgcacattct attggtaaag 1846741 gagggatgta aagaatggaa atcgaaagaa tcattcagta tatttgcacc tttttaggcg 1846801 tgatttcgct ttcttttatt tatgcccaaa tgtttagaaa aacgaaaccg acaaaaaaag 1846861 aataggcccg gcgttcattg ctttttatac ataaaatgtt ataatttctc tcgttatgaa 1846921 aaagaaacgg agatcaatgt atgaaagaaa ctcaaaacgc ccgggaaaaa atcaaacagc 1846981 tcttgcacat tttaataccg atattcatta cccaagcggg gctttctctg atcacttttc 1847041 tagatactgt gatgtcaggg aaagtcagcc ccgctgattt agctggtgtc gccattggct 1847101 caagcctttg gacccctgtt tacacaggac ttgcaggtat attaatggcg gtcaccccga 1847161 ttgtcgctca gttattaggt gcagagaaaa aacagaagat tccctttact gttttacaag 1847221 ctgtatacgt ggccgcgctt cttagcatcg ccgttttagt gattggatat gctgcagttg 1847281 accttattct tggccgattg aaccttgata ttcacgtgca tcagattgct aaacactttt 1847341 taggcttttt atcactggga attttccctt tatttgttta caccgtgttg agatcattca 1847401 tcgactcatt aggaaaaacg agagtcacca tgatgattac actcagttct cttccaatca 1847461 attttgtatt gaattatgta tttatcttcg ggaagttcgg aatgccggca cttggaggtg 1847521 taggcgcggg actggcatcc gcgttaactt actggtgtat atgcatcatc agttttttca 1847581 ttattcataa aaacgcaccg ttttctgaat acgggatttt tcttaccatg tataagttct 1847641 cttggaaagc atgcaaaaat ttgctcaaaa tcgggctgcc tattgggttc gccgtgtttt 1847701 ttgaaacgag cattttcgca gctgtcacgc ttctcatgag ccattttcat acagtgacca 1847761 tcgcgtccca ccaggcagcc atgaattttg cgtctctttt atatatgctg ccgcttagcg 1847821 tgtccatggc tctaacaatt gttgtcggat ttgaagcggg tgcagcccgt tttaaggatg 1847881 cacgctcata tagcttaatc ggcatcatga tggcgatcgg cttttctttg ttcactgccg 1847941 cctgtatcct tttattcaga gagcaaattg cgggcatgta cacttctgac cccgatgtgc 1848001 tccggctgac acagcacttt ttaatttatg cgctattttt tcagctttcc gatgctgttg 1848061 ccgcaccgat ccagggagca ctcagagggt acaaagatgt gaactatacg cttgcggccg 1848121 cttttgtctc ttactgggtc attggccttc cggtcggtta tatggtcggt acgtttacaa 1848181 gcctcggtgc attcggctat tggattggat taatagcggg actcgccgcc ggagcagttg 1848241 ggctgttttt caggctggca aaactgcaaa aacgttattc gcaaaaacaa cacatttaaa 1848301 agaggtgatc aatcatggca aaaaacaaaa aattattcga gtatctttcc cagcatgcgg 1848361 aaaccatcag ttcaacatgg tatgaaacaa tcgaggagac tgatcccaat tccatttatg 1848421 cctcaacaga ccctgttgtc attcacaatt taaagagcca gaatcttgcc tttaactata 1848481 aaataaaccg tatttttata gatgatgagg acgtatactt gcctatactg aaagaatggg 1848541 cctttgaagt cacacaggat caagagcatt taaaaactcc tatccactat attattcggg 1848601 agtttgtcag agtgagagat ttatatgttt cttatgtgaa agaatttgtc catctcaatc 1848661 agaatactgt gaaaagcgaa gaagccgaag acctgtatca cgcccttata aaagcgtttg 1848721 atcttgtgat tcatattttt atagaagaaa tgtacaaaaa cacaagcctt cagcttcagg 1848781 cccaaaaaga tatgattact gaattgagcg ctccggtcat cgtgctgttt cacagcgtcg 1848841 gactgctgcc tttaatcgga gatattgata cagtccgcgc caagctgatt atggaaaaca 1848901 cactgcatca atgtgcgaaa aaaaaggtga cacaactgta tattgatttg tcaggagtag 1848961 ctgtgattga tacgatggtt gcccatcagc tgttcagtct gattgaggcg cttcgtttaa 1849021 tcggtgtttc ttcaactttg tctggaatcc gtccggaaat cgcgcaaaca gcggttcagc 1849081 taggtttgtc tttcgaaggt atttccttga gatccactct cgcttcagct attgcatcgg 1849141 acttaaaatt aaaaaaggta taaggcttaa ggccttatac ctttttgatt aatcattcca 1849201 ttgatacgtc caatatattt cttcttcaaa ccatgttgcc ataacaggtt cattattttt 1849261 caatttctct tcaagctctc tgagcatgcc ttctgtttgt gtgcggtgag ctcttaacgc 1849321 attcatttta atatcagcta cttctttgat atcaagtacg acatcagctt cgccgagaac 1849381 ctcttctctg ttgcgggtaa tggccatgca gattgtacgc ggacggtctt ctttcttttt 1849441 gcggtataat gcacggataa ccgcttcccc gcatgcatca tggtcagggt gcacaccgtg 1849501 tccgggataa aatgtgacaa ttaaacttgg ttttacatca tctatgatct cttccatgat 1849561 atcagctaaa tactcatcgt cttcaaattc gagcgttttg tcacggagtc caagcatccg 1849621 aaggtcattg atatccattt ctttgcaagc gttgatgagc tcttgttttc ttagcagcgg 1849681 caacgtttcc cgattcgcga aaaatggatc gcccatattt ctgcccattt cacctaaagt 1849741 ggcgcaggca tacgtaacgg gaatgtcttt ttttctgttt aaggcaatga ggcctgccac 1849801 tccatatgat tcatcatcag ggtgaggcag gattactagt acatgttctt tcattattat 1849861 tcaccctttt ctttaaactg tgaacggttt ttcgctgatt tgcagagaaa tagccagttt 1849921 accgcccggc aggtgtcccg ccattaataa acggttttct tcatctaccg tgtattcagt 1849981 caagccttca gcataaatcc agccttcttc tgttttcaag ccaacgcggt aaggcccgtt 1850041 gcctttgatt tttgcctgat gataagtgac ttttgcattg cgaatatacg caacaaccgt 1850101 catgttcttt tcatttaagt gcgctgaata agaacctgtg gtggtttcta aatggatata 1850161 tacagggcgg tccgcatatc gttctaaaga tgcttgcaca tcttctttta tgatcgcttt 1850221 catgattgct cccctctttc ttcttttaaa tactctgcac gttctgtatg taatttgacc 1850281 agctgatatt tcacagccgg ttcgagctgt gaattcacaa tgcgctgaat cgcggcaaaa 1850341 tatttttcca gcatcggttt tcggagtctt ggatgtgttc gtttatccaa gagctcaaga 1850401 tcaatcgcct ctgctaccgc ttctgcgtca tcatgtgcga gagatcggtt attccaaagt 1850461 gaagcatagg ctttcactat ctctttatca ttgtccatcg tcttgctcct ttatgtctta 1850521 catacatgaa atgattatac ataatatatg catcagctga aaagccaaag gcctcaatgg 1850581 ctttttgacg cccgtttcca cttcacttgt gaaaacgtaa acaagagcag cgcagcccat 1850641 atacagctga atgtaaaagc cttcgagctt gaaaatggct catggtaaac aaacagcccg 1850701 atcagcaggg taatggtcgg cgcaatatat tgtaagatac cgacttgata cagtggcagc 1850761 cgtttcgctc cttccgcaaa caataagagc ggcaaagccg taaacacacc ggccaaaaag 1850821 agaagcagcc acgtccctcc gctttctgca cccgctggct gaacatgtcc gctgaacagc 1850881 aaatacccca atgcaatggg cataatcatg aatgtttcca gcgttaaacc gatggcgctc 1850941 ggcaggcttg ttcttttttt gcttaacccg tacagcccaa agctgaatgc gagcagaagc 1851001 gcaacataag gaatggagcc gtattggaac gccgagatga tgacaccggc tgccgcaatc 1851061 gaaacggcca ctaattgcag gcgattcagt ttttccttta aaaataaaat cccaaggagc 1851121 actgatacaa gcggattaat gtaatagcca agactagcct caagcaaaaa gccatggttg 1851181 acagcccata tgtatacaaa ccagttgatc gaaatcagga tagaagcaag aaataaagag 1851241 aggatccctc cgttcttttt cagagagcgc aactcctgcc atcctatttt ccattgccgc 1851301 aagaaaaaaa gtacgataca cataaaaaca aaagaccata taatacgatg agccaaaata 1851361 tcaagagccg gcagctgttc gagaagcttc caatagagcg gaaacaggcc ccacatgata 1851421 aatgaaacgg ctgtgtaaat aacgcctttt tttgtttctg catgttgcat tgatatccct 1851481 gcctttcttt agagcatctt atattatatc acgtgaaaga tctggtgggc atatactatt 1851541 ttgtccgtga agaaaggatg tgaagacaat gtttgagtgg aacaagtact ttcctttcca 1851601 caatcaattt tctaaagaag cattaaaaaa agctgatccg aaagaagttg aaacgtatgt 1851661 caatcgtgtg atggaaagtg tgttcggcag tgattatgcg gctcaatttc ctttccgcga 1851721 tcctctcccc caaaaagaac atcccgccaa acctgatgca aaacctgatg tcaaacctga 1851781 tattgatata ttcgaaacag cagaccatgt gtttgtaaag gtgccaatca gcgaagaatg 1851841 gctggaacaa gtgagaatca aacacacatc tcacgaatta tggttggaaa acctcccaag 1851901 agcagatcat ccgaaaaaag taaaccttcc ttgtttagtc aaacgcaaag gaacaaaagc 1851961 cgtctataag gatggccttc tggaagtcat gtttcaaaag cagcaagact acaatatgtc 1852021 cgaggtagaa atcatccgat aaaaaacggc ctgcaatcga tgcaggccgt tttttattaa 1852081 tagaagccgg gatatccccc gtatggcacg ccggcaccaa aaccgtacgg tccgcctcca 1852141 tatccataag ggccaggagg ataggcatag ggacgagaat agttaaacag cgcactcccg 1852201 agaaaaccgc ctaataaacc gccgactaga ggagcgccaa acaaaaaagg actacgcgcc 1852261 ggatatccgg ctggacctgg gattccgcgt aaatacgaat gatgagggta catgattttt 1852321 tcctccttta tgtctgccta tacgtaaagt attcagcaag gaagaaaaac gattgggcta 1852381 cggactgtct atgattgtta catcacaagc cctgccaata acacacagcc gagccctgta 1852441 accgaaagaa ctgttgtaag cagcgtccag gtttgaaatg tttctttcat gctcaagccg 1852501 aaaaattcct ttaccatcca aaatcctgca tcatttacat gacacgcaat gacactgccg 1852561 gctcctgttg caagcaccat taacgcaggg tttacactgc cagcctccat aagcggagct 1852621 gccattcccg ctgtggtaag cgcagccacg gtagcagagc ctagacacag acgcagaacc 1852681 gcggcgatgg tccatgcaac gaatagcggc gacatgtttg tttgacggaa aaaatcagcg 1852741 acataatcgc cgactccgcc gtcaatcagc acctgtttaa acgctcctcc ccctcctatg 1852801 atgagcagca tcatcgcaat ttgcgaaatt gattctgaaa tagatctgcc gatttcctgc 1852861 atagatattt tacgggcata tcccatcgta tagagtgcaa gcaacagcga aatgagcatt 1852921 gccgttcccg gagtgccgat aaattctata atgtcttttc cttttgaatg ttcactcaat 1852981 aataaagaaa aaattgttgc cattgccata aagataaccg ggaataaaga cgtgacagca 1853041 ctgatcgcaa agcccggtgt ttcatccagc tgaaattctt tccttggtcc taaccccgat 1853101 aggtttccat gcttttgata cgcaccagga aaccgtttca tcgcaaattt attaaataaa 1853161 ggcccggcaa tcacagttgt cggaacagcg atgatgattc caaaaagcag cacctggcca 1853221 atatgggcac catatgcaac tgagatagca gttggagcag gatgcggggg caaaaatccg 1853281 tgagtaacat ttaaggcggc ggccatcggg attcccagat acagaaaagg catttttaat 1853341 tctttagcaa tcgcgtaaac aatcggtatc aacagaacaa gaccgacttc aaaaaatagg 1853401 gcaatcccga tgataaaaga ggcaaccaca accgccgcct gtattcgttt cctcccgaat 1853461 ttgtcaatca gcgtaatggc gatccggtag ccgcccccag catctgagac aagcctccca 1853521 agcatcgcgc caagtccaaa cactaaagct aaatgcccca gctgcccgcc aattccagtc 1853581 tcaattgaaa gaacaatttt attgatatcc attccaagtc cgatggctac taaaaatgaa 1853641 acgacaatca gtgagacaaa ggtatttaat tttactttaa taatgagaaa taacagaatc 1853701 agcactccga cagctacaat taaaatcggc atggtacccc tccaaaagtg ttttatatga 1853761 ttctcgcgac aatgttttgg cgcttttcat gcctagatga acagaaagcg ctttcattaa 1853821 taactaaaaa cgtcttggtt atatgattgt tatcttttga tcaactaata tgttcatact 1853881 aatctcctaa tcaatgactg tcaatcgttt ttatgagctt gtctcgatta cctaccgcct 1853941 aacccaatga tttattagtt atatgttgat taacttttgg ttatatgtta tgttttttaa 1854001 agttgactgc caatcattat atctctccat tgtctggaag caaatgagac aatatgagaa 1854061 cagacggata acaacttcat aagaggagga gtacacatgc cattattgcg ttttgatgta 1854121 attgagggcc gtgatgaaaa atcgctgcaa ttgttattag atactgctca ccaagcgatg 1854181 gttgaagcat ttggtgttcc ggaaagagac cgttatcaaa ttgtccatca gcatcccgca 1854241 aacgagctta taatccagga tgcgggatta gggtttcaga gaaccaagga tatggtcatc 1854301 attagcatga caagcaaagc aagaaccgaa agccaaaagg aaaaattgta tgctctgctt 1854361 gctgaaaggc tagaaaaaaa atgcgaaatt tcccctgacg acctcatggt atctattact 1854421 gagaatggtg acgcagactg gagtttcggt ctcggtgagg cgcaattttt gaatggaaaa 1854481 ctataagatt tcgtctcccc acaaaaaaaa gaagagagag ctccaaagaa gctctctctt 1854541 ttttcataaa tgcggaagtc atcagtatag aagcatccag caatacgaaa aacctggatc 1854601 tccttttata tccggtttaa atgccaattg gaagctgact gggttttggc tgaaaatata 1854661 aaattttgct gatttgcata ataagataca tcataatccc catttacaat aggttggatg 1854721 ttatagctta ttgatcattt cctattttat atatcccctt catatgcaca tgacattttt 1854781 gccaatccgg aaatatcagt ctgacaaata taaaaagtca tgtaaacggg tgtgaaccgt 1854841 acttacatga ctcaccatgg aaacaaaggc tctttttcag gtgccgcttt ccttatttct 1854901 cttcttcaca cactgtgtca ccaggctcgc aaaattgatc ggcccatgcc tgcatttctt 1854961 gaaatacagc ttgaagcgct gttccttttt cagtcagcgt gtagatgact ttgaccggcg 1855021 tttcagggag aacctgccgt tcgacaatct cgttttgttc aagctccttc aagcgctctg 1855081 ccaacatttt ttggctgatc atcggtattg tttccgttat ctctttaaac cgtttcggcc 1855141 catccattag cacatggatg atcagaccgt tccatcgttt tcccagcaat gagaatgcgg 1855201 attccatttt agggcacatc gtatttccca taagtcttca tcccttcatc tattgattga 1855261 catgtattca atgatccatt acaataatct ttcaagttac atttagtaag cttctaactt 1855321 ttctattatc ataccacgtt tatccgaagg aggaaacact atgacgaata ctctggatgt 1855381 tttaaaagca cgtgcatctg taaaggaata tgatacaaat gccccgatct ctaaggagga 1855441 gctgactgag ctattagacc ttgccactaa agcgccttct gcttggaacc ttcagcattg 1855501 gcattttaca gtattccaca gcgatgaatc aaaagcggag cttcttcctg tagcgtataa 1855561 tcaaaaacaa atcgttgagt cttctgctgt tgttgccatt ttaggcgatt taaaggcaaa 1855621 tgaaaacggt gaagaagttt atgctgaatt agcaagccaa ggctatatta cggatgaaat 1855681 caaacaaaca ttgctcggcc aaatcaacgg tgcttaccaa agcgagcaat tcgcacgtga 1855741 ttccgctttc ttaaatgctt ctttagctgc tatgcagctt atgattgccg caaaagcaaa 1855801 aggttatgac acttgcgcaa tcggcggatt taacaaagag cagttccaaa agcaatttga 1855861 tatcagtgag cgctatgttc cggttatgct tatttcaatc ggcaaagcag tgaagcctgc 1855921 gcatcaaagc aaccgtctgc cgctttcaaa agtatcaact tggctgtaag gatatgaaaa 1855981 accttagtcc gaaatccgga ctaaggtttt tttatacaat cgcctctttg taccattcac 1856041 gagcctgttc agcttcatgc tgagtcagct gatggccccc gtcctgccag taaacggagg 1856101 ctgatgcccc gctgtcacgc aaatagcggt aaagctcttc tgattcttcc ttcgtgcaaa 1856161 gaggatcgta tttcccggca ccgataaaaa cagggagccc cgccatatca ggcagctcga 1856221 taccccgaat cggaaccatt ggatgatgca gaatagcccc ttttaacaca tctttataat 1856281 gaaaaagcag gcttgccgca atgtttgcgc cgtttgaata accgactgca atcactcggc 1856341 cgcgattaaa ctgatgcgtt tctgcagcct cgtcgataaa atctttcaat tctcttgtcc 1856401 gcaccacaag atccttttca tcaaaaactc cttcactcag acgtttgaaa aatcgcggca 1856461 ttccattttc aagcaccgat cctctgacac caagcaaatg ggcatcaggg tctataaacc 1856521 gccccaatga aagcagatcg tgttcattac cacccgtgcc atgcaacagc aaaagtacgt 1856581 tgtcagatgt tcctttctca taaatatgct tcattataaa ttcccccttt taaagttcag 1856641 gtaaaatgtc tgtaatttgt tgtctatgtt tctccagcca ttcaggcagt tttaaggaag 1856701 tccctagctc agcaaacgtt tcatctgtca taaagcccgg ttcatctgtg gcaatttcaa 1856761 ataagatacc gcctttctcc ctaaaataaa ctgatgtaaa gtattccctg tcgagaattt 1856821 ctgacgaagg cagatggttt tcagcaataa tcggcagcca tttcgcctgt tcctttttct 1856881 tagtccgaaa cgctacatgg tgtaccgtac catatcctcc gactcctctt ttttcaggat 1856941 gtaaatggac atcaatgaca ccgccgaccg ccgctgaaga tgccagtctg acaatctggt 1857001 cttcttcggc cactttggtg tatccaaagc tttccgttaa caattgtatg gtcgcctgcg 1857061 ggtcgtagga atatagcagc acacctttca ttcccgtaat tgcttcattt gttgtgatcc 1857121 cgtcaggcgt ccactcgctt ttgccgcttt tcgcatcctc catgatcgcc agcggaaggt 1857181 cttctgtatc atcaaaaata agaccttttt caccaaacaa cgttttttcc tctaggctca 1857241 gcccgctttt ctcaagacgt tccttccaaa aagacaggga gcctgaggga actgaaaagt 1857301 acacccggcc cgcttggcct tttcctaccg ttccctgtcc gcttccttgg aacggaaaaa 1857361 aggtcattat tgtaccggga tctccgtttt gattcccaaa gtaaaaatga tacgttccgg 1857421 gatcatcaaa gtttactgtt tttttaacga gcctgagccc aagcacttct gtataaaatc 1857481 gcaagttttc ttgcggatct ctggcgaatg ctgtgacatg gtgcaatcct tctgttttca 1857541 ttttctcact cctatttatc tcgatttcaa gatatttatt attttaaacc tttattgaaa 1857601 aggatgcaaa ccatgtgttt tgattaaata attgaaaaaa tcattttttt ctaataatta 1857661 tcttgtgatc ttttcttaca actgctatta tagtgagcat tatcatgttt caggaggaaa 1857721 gtaaatggtt aaaaaagcac ttattgttat tctcattctt ttgccattcg ttcagctcgc 1857781 gcttttgccg cttgtgaatc gaatagaacc gattatgttc ggcctgccgt ttttccactt 1857841 ttggctgctg ctgtggatta ttgttacgcc gttatgctcg tttggcattt atcagatgca 1857901 aaaaaaagat ggaggacttg aataatgcaa gggaatctga ctgcacttct cattactgct 1857961 attattgttt taaccgttgt ctgtatcggc tttctcgccg gaagagacaa atcctcacgt 1858021 acttctgtgg aagaatggtc tgtcggcggc agacgcttcg gcggtcttct cgtctggttt 1858081 ttagtaggcg ctgaccttta tacggcctat actttcttag ggttgaccag tactgctttt 1858141 acaggcggaa gtgttgcatt tttcgccatt ccttattctg tgttggccta ctttatcgcc 1858201 tacttcttct tgccaaaact ttggaaagtt gcgaaaattc ataaattaac aacactcgcg 1858261 gattatgccc gggaacgttt taacagtaag cttttggcaa gcctcgttgc catcgttggg 1858321 gtactcatgc ttattccgta catatgcctt cagctgagcg gcattcaaga cacgcttcag 1858381 gttgccggca ctggctatat taacgtaaaa ttcgttgtga tcatttcatt tattcttgtt 1858441 gctctttaca cattcttcag cgggattaaa gggcccacat atacagccat cattaaggac 1858501 attttagtat gggtcattat gctgtttatg gtggtgtccc tccctctcat tcattttaac 1858561 ggctggacgc caatgattga cacgttagtg aaggaagcgc cgcaaatgct gacgataccg 1858621 tcagaagggc caaaaggcat tccttggttt atcacagcat ctattgtttc cgctctggca 1858681 ctttttatgt gggcacatgc cgctacaggt gttttcacgg cgaaaagcgc tgatgcagta 1858741 agaaaaaaca gcatgttttt gccgctttat aatatcgtgt taattttggt tatttttctt 1858801 ggctttatcg cctttcttgt tctgccggaa gatacaaatc caaggctggc gctgctgcat 1858861 ttgattcaaa catcttacgg cggcgtggca caaggctttg catatgccac tatcgctctt 1858921 gcttcattaa taccttgttc cattatggca atcggcgcat cgaatttatt cgccaacaac 1858981 ctataccggg atttgattca tccgaatgtg tcgcaaagca agctgactct tgtcacacgt 1859041 tcaatggtgt ttgttgtcat cggtcttgcg ctgctgtttg gaatgctgtt cccgactgcc 1859101 ttagtgacac ttcagctatt aggtgtatcc ggtatggtgc aaatcttccc tgcgattgct 1859161 gtcagcctgt tctggaaaaa ccaaacgaaa gaagcaacgg ttatcggatt attagccggc 1859221 ctagcggtaa cgtttattgt gtatatcact caatccgcac atggcattta tgaaggattc 1859281 tggggattgg ccgccaacat gatcgctgtg gtcatcctga atccgctgtt cgttaaaaac 1859341 gcgggatcca atcctgtcat tgaaggttta tttggcaaaa aacaagacgc taatccaaat 1859401 caaaagggcg cataaaaaaa ccatacgcgg cagccgcgta tggttttttt tacatttctt 1859461 ttttcagtgt ttcaattgcc ttttccattt gcgtatcatt atcagacagc ttcttttgaa 1859521 gttctatcat taatttcgtt gttgtatcgc cagtcagtat gcctgtttca ttcagcttct 1859581 cttttttctg gaactgtttg acgacagata caaaatcctg gtcatacata ctgttaacct 1859641 ttaccttgta accaagtgct ttgagcattt tctgagccac tttgacgttt gtgcctgtat 1859701 cacctgattt gtacgtttta tctgcgtcca aatacggcag cttcgcgtaa tcaggcagct 1859761 ctgctttcac ttgaggcttg atgccttttt tgtgaatcca ttcgccatca gcagtcagcc 1859821 atttggcaac tgtcagtttg acggtagagc catcatcata ttcttttgcc gtttgtactg 1859881 tacctttgcc gaatgtcgtc tcgccgatta acggtacgtt tgacgattca tgaagggcag 1859941 cggccataat ttcggctgcg cttgctgtac cgtcatttac taaaacgacg gtcggcttgg 1860001 tcactttccg ttctttttcg gccttcatga cttcttttga accgtttttg tattcaacct 1860061 gcatgatgtt tttcccttta tcaatgaaca ggttgctcat cgtaatcgcc tgttccatta 1860121 agccgcccgg gttgcctctc aagtctaaaa tatagccttt ggcgcctttt ttctctaaac 1860181 tgtcaatcgc atctgtcagc tctttagctg ttgtttcaga gaaagaagtg atttgaattt 1860241 ctccgatgtt gttgtctttc atctctgaat agacagtctc tacaggaatg gtatcgcgct 1860301 taatggaaag atcgatattc cccactcccg ctctgttcag ttcaagcttc acctttgtgc 1860361 cctttttgcc tcggattaaa gcgacggctt catttacatt catgcctttt acgctttttc 1860421 catttacctt aatgatttgg tccctcggtt tgataccggc tttttcagca ggtgaacctt 1860481 taattgggga tacaataagg atttctccgt ctttctcctc tacttgggct ccgattcctt 1860541 caaaagatgc tgaaatcgtc tcgtcgaatg atttcgcttg ctcttgatcc atatatgtag 1860601 aatacggatc atccagtgat tgaatcattc ctttaattgc tccgtctact aatttgtcat 1860661 catctgtttt ttggtaataa tcacttttga tttgctcata cgctttattt aatttgtcga 1860721 acttgctgtc tcctgtgctt gctgattttt ggcccaggat actggaattg cccgtaataa 1860781 ataaagtaag cgccgaagcg acaactgcag tgatcagcac aataaaaaac agttttaatt 1860841 gccgtttcaa ttaaacacca cctttttctt cttacattat tatcatggac gaattcttat 1860901 tcgtcaactc ggagcagaaa tgaaagagaa acgcccttct tttgcttttc ataaacctat 1860961 gtctttatac gacatatgat aaggaaaaag gaggattcga tattgagccg atatttagaa 1861021 atgctgtcct tattcggtgt cgcaggggcg cacccaggcg ggctggcttt ttcaaaagcg 1861081 gtcttgcaaa aggctgcacc ctctccggat cagccgattc ttgatgccgg atgcggaaca 1861141 gggcaaacgg cggcttattt aggacatttg ctgtatcctg taacagtcgt tgataaagat 1861201 cctattatgc ttgagaaagc gaaaaaaaga tttgcgaatg aagggcttgc catccctgca 1861261 tatcaggcgg agctggaaca tctcccgttt tcttctgagt ccttttcctg cgtcctgtca 1861321 gaatcggtcc tcagtttttc acgcctgaca tcctctcttc aagaaatttc aagagtttta 1861381 aaacccagcg ggatgctgat tggtatcgaa gctgctttaa aaaaaccaat gccccctgca 1861441 gaaaagaagc aaatgatgga tttttacgga tttacttgct tacatgaaga aagcgaatgg 1861501 cataaactcc taagatccta tggctttcaa aaaacagaag cgatgtcact tcttccggaa 1861561 gacatggaat ttgaaccaac cacagaaatg gatttatcgc aaacgattga tcccatctat 1861621 tacgatacgc ttcaaacaca ttatcagctc atgcagttat atagtgagta catgggtcat 1861681 tgtattttta tcgcgtacaa gtaaaacggc gtatcgcccc ctgttttcgt ccaacctttt 1861741 tttcctatct atcatatgct gatagaaagt caggatagga ggggaacaat attggagaga 1861801 tattatcatc tttgcaaaaa ccatcaaggt aaagtcgtca gaattacaga gagaggcggg 1861861 agagttcacg tcggcagaat tacccgtgta acaagagaca gagtttttat agctccggtc 1861921 ggcggagggc caagaggttt cggttacgga tattggggcg gttattgggg atatggagcg 1861981 gcttacggga tttccctcgg tttaattgca ggagtggctc tggctggttt attcttctgg 1862041 taagcataga acaaatgcta gattcaccag acacaatgaa gcccgcttat ctagtgtaag 1862101 cgggcttttc attttaaatt ttcttcactt tttcaaagta ctcttcaagc gttaaatcat 1862161 tatcttggat gacctttgcg gcttttttgc ctacatagcg cagatgccat ggctcatatt 1862221 catatttcgt gatatcttct ttatttttcg gatagcgaat aataaagcca tatttataag 1862281 cattgtcctg cacccatttc ccgtctgccg tgcttccgaa cgcttcattt agctcaaagc 1862341 cattgctccg gctcgaaatg tccatcgcaa ggcctgtttg atgctcgctt tcacccgggt 1862401 aagcgaccgc ttcctttgcc ttcctttccc cttttaggct tacttcattg tcaaaaatga 1862461 ctttctgtct gtcatacgaa cggtaccctg agacagctgc cagttcatag ccttcctttt 1862521 tggcagcatc gaacattgtt tttaatgcgt cggccgcttc ttttctgatg taacgttttt 1862581 gaatcttttc ttcaaaagaa aactctacat caggtatgac aagatcgcta ggttcatagt 1862641 ttccgggcag tgcatattgt ttattgacaa gcgcgagtat attttctgga ttttgaatgg 1862701 tttccagacc atcgactttt ttaatatcat tgaaatactg gctttccaat gaaaactcac 1862761 tgttttgagt gtttgatttt ttgctgtcag ctgttttttg ttctgtttgc tttgtttctg 1862821 ctgtggtttt cgtatccttt tgagcatctc cgttcgacat gctgcagccg gctccgacta 1862881 ttgccgttac actcagagcg gcagccagtg agaaccattt accggacttt ttcatattac 1862941 attaccttcc ttttatcaat cgtttccgca tgcataaaga agaggctgcc ggcacccagc 1863001 acgcctcttg atatatttta ttgtgatacg gaatgtaaag ccacttctat catatcatga 1863061 aatgtcgttt gacgctcttc cgctgtcgtt tcttctcctg ttaatacgtg atcactcacg 1863121 gtgagaattg acagggcttt tcttccgtgc ttcgctgcta atgtatacaa tgcagttgtt 1863181 tccatttcaa cgccaagcac accgtatttt gcaagttttt caatttgcga atcgtcattg 1863241 tagaactggt cagctgtaaa tacgcttcct acagtcaccg gcacaccttt atcctttgcg 1863301 gcatcatagg cattttttaa aagctcgaaa tctgcgcaag gcgcaaaatc aacgcttccg 1863361 aaagcaactc tgttcatttg tgaatcagtt gaggaggtca tcgccaaaat gacgtctcgc 1863421 actttgacat ctttacgaat agcgccgcag gaaccgactc ttattagatt ttgcacatcg 1863481 tagctttgaa ttaattcatt cacataaatt gaaatagacg gaactcccat tcccgtgcct 1863541 tgtactgaga tttttttacc tttatatgta cccgtaaatc catacatgcc tctgacttca 1863601 ttgtagcatt ctacattttc aagatacgtt tctgcaataa attttgctct gagaggatct 1863661 cccggcaaaa gcacagtatc cgcaatttgt cctttttcag cacctatatg tacactcatc 1863721 tcatatcctc ctgtaaatct aaattatcat ccagcccgtc cattttacaa cgaatgtcat 1863781 gatgaaacaa acttcagcat tgattataaa ggaatatatc gaaaaaagaa atgttcgagg 1863841 atctgttagg cacttcctca gaaaaacgga taatcggggt gttaatttga aaacctaacc 1863901 gcaggaagga ggggtgggac atgggtaaaa aacatcgtaa ccggatcacc ggccaaaaaa 1863961 agaacaatca tatacctgaa aaagatatca ttgcagctga agaagcacac gggaaagaat 1864021 attccgctgc caaacgcaag ccttaaaact gcagaaaact gcgggtttcc gcagttttct 1864081 tttcattatg tcgtttgtac aatcagacga ttgattttcc tccagccggc gggaagcagt 1864141 tgataatatg ttttcccttt tctgccttca tcaatcagga tcacgtcccc tgtggccatg 1864201 aatcttgcat cataatcact cggaacagtg tcgaatacat taaacaaaga gaatgctctt 1864261 ttcagcacgt cttgatgatc gctcccgttc agttcagttc gatagacggc tctgtagccc 1864321 tttttttcgc caaaccgggg tgtctgaaat attgtcacgt cataggaaca agacttcttt 1864381 ttaaacacgg ataacatcat caagatcccc tcccttttat ttctttaaca tattggcgtt 1864441 tttgctgtgt tttcctctct ctatttttgt cgaaaccgct taatcttttc gtcaaaacct 1864501 tttactagga aaaacagaag caagccgagg ctaaagcctc ctaacacgtc tgtcacaaaa 1864561 tgaaccccca gatacactct gcttatgccg actaaaacag caattacacc ggctatgata 1864621 tataccattt ttttatgctt agacaaaaac gggagatgtt tcactaaaaa gtaagcaata 1864681 acaggataga cacaagcagc attcatggaa tggccgctcg gaaaactgaa ggatgattca 1864741 tgaaccagcg gtgcaaaatc aggcctcact ctttcgatcc attcttttaa gactttgttt 1864801 aacagccgat ctgtgccgaa tactaagagc atcaacaggc cgtcccatgt ttttctgtag 1864861 aaaaacatgc ctgctccaat gatgacaatt agagggagca gaaaagaaga agcaccaaga 1864921 tgcgtgatcc ccgtcatgac ttcattaagc catggctgac ggatcaaaac agctgccttg 1864981 cttattgctt catctgcaga ttgaacagca tttgtatgaa tggccgcagc tagaattaaa 1865041 aagaaaagaa acaaactaac gggcttgtac aattttaacc acctcaattt tcacagaagt 1865101 catagaacat gaataataaa accggagctg accgctccgg ttttaagcct cactcatctt 1865161 catccagctc ttcatctatc atacattttt ctatcaaata atcaaaggta atatcagcga 1865221 tttcaaacag ctcatcctca ctcggtatgt agccccgtct tgcaagctct ctgtaaaaaa 1865281 attcagcgat ttcttccgta tcaatcacaa gatctatttc tttcatctcc gtaccgcctc 1865341 cttttttatg ttttatgaaa aaacaggctg aattataccc ggtgttctaa acaattcttt 1865401 cagtcatata ttgaataaaa aacgagccat gggaggctga cgctatgatt gctaaaatga 1865461 tggaagcact ggacggagaa agatttgata tcataatgga aaaaacgctc aaaggaatga 1865521 cgcgtgtgat gatttggggc tgtctgccat attttttata tgtcttgatc cgtatgttca 1865581 caaattaact gaaatgctct tttaaacttt ccaaaacaaa catcatcatg tctttatatt 1865641 cttcatcctg aaacatttcg tacagaattt tgtagtcatt ataaatatcc agaagctcat 1865701 caacaattga cacagcaagg atgtgaaggg tatcttgatc ttcatcaccg ccttcaaact 1865761 gaagaagagc agacgatgcg atatcttcgc cgatctcatg gccagtttct ccgacataat 1865821 ggacaaacaa cagctgatgc acaaactggt ccatttcata ttttctaagc accagcgtga 1865881 gatcctcttc ctccgtttca agccactctc catcctttaa acgggtcagc tcataaatga 1865941 tatcttccca gccatcttct aaatatctcc aaatttctgt tctatggccg ataatgcgaa 1866001 agagttcttt tccataatct ttaacataaa caacgtcccc aataaggaat tcatactcaa 1866061 tatcaagctt ctccatgtcg acaatgacac cctcataatc tttataaagc tgaatagatg 1866121 attcaaagta taaaacttcg ttatgattga cttcataaag atagtgttta tcaatttggt 1866181 gtacttttgt gatggtgccg actgttccat acataatgac gactacgata tcccctactt 1866241 ggaatttcgg tttattttgc ttcatggtgt ctccccctcg ccgcaacatt tctcatacgc 1866301 tatcgtatgc cgggtgaagc caattcgcat gggcatgaaa accaaaggaa atatccaatt 1866361 atggtatggg tatggacata aaaaaatccg cagtgatctg cggatgaaac agctattatc 1866421 tgccgtgcac ttcagactcg tattgatccc aagcttcatc aaacgtcgcc atcgtgtgaa 1866481 ggtaatcagc attcagctcc aaatatgaac tgatttcatg ataatcggtt gatgtttttg 1866541 gaaagctgtg atcctcatac gcctgattgg caaattcact gatgctgtcc ttcggcttag 1866601 ggtgtctgta tttcaataaa tagtgataaa aggatttcat gggtttcccc tcctgatgtc 1866661 tgtcttttgt tgttctatta tacagttcaa gtgtaaaatt acaacaaaag aatactgaaa 1866721 catgactcag gagaagtcaa aatagttgcg tttcaaaatt ctttctgtct ccatgagctg 1866781 ctgatatgtc aggctttcag gcagtttttt tgtttgaatt aaaagcagct gatcctcaat 1866841 ctctttaacc gtgttttcct cttgataggt cataccgcag gaagaacata ccatggcagg 1866901 ggtgtctgtc agttctatag ccctcgttcc atcagggagc tcccagtaca ccgtgttcct 1866961 gccgggcacc gcttcgagct cgccgcacca ttcgcatgtt ttcatgaaga atcccctccg 1867021 cattcagtct ctttctgttt tttctgctgc gccaaaaatt tcttttcttt gagctgatct 1867081 cttttctcac gccgatcttt taatgtttca tgctccggat ttgcgatgta tgcctctctc 1867141 cttttgattc tgtctacatt ttcaggtgta aacgaaactt ctttgtcagc aaaaatggca 1867201 ctcagcccga tcggctcctt tttgtcagcg gtttcaggga aaacggactc aaaataggcg 1867261 tctgcctgat tggggatata attctctggt tccggatatg acgtaatcac accttcaaaa 1867321 tttcttaaga tcactttgtc aggactttgt gacaggacat agtttggctg cagggcgatt 1867381 ttacctcctc cgcctggtgc gtcaacgaca aaggtaggaa ccgcatagcc tgaggtatga 1867441 cctctcagcc cttcaatgat ctccaaacct ttggaaacag gagctctgaa atgccctatt 1867501 ccttctgaca gatcacattg gtaaatataa taaggacgga ctctgatttt taccaagtca 1867561 tgcatgagct ttttcataat tggaaccgaa tcattaatac ctgctaatac gacagcctga 1867621 tttccgaccg gcactcccgc gttcaccagc ttttcacatg cctcaacgga ttcttctgtc 1867681 atttcgatgc ttgtgttaaa atgggtgttc agccagaccg gatgatattt tttcaatatc 1867741 tcgcacagat gatcggtaat gcgctgcgga aagacgacgg gagctcttgt tccgattctg 1867801 atgacttcca gatgcggaat gctgcgcagc tcttttaaaa tatattctaa aatttggtcg 1867861 ttgatgagca gcccatcacc gcctgaaatt aaacaatcgc ggatttcggg tgtttcccgg 1867921 atataagcaa ttgcagcatc aagctgtttt ttggggacgc ccattccgat ttgtccggaa 1867981 aagcgccttc ttgtgcagta gcggcagtac atggaacatt gattcgtgac aagaaacagc 1868041 acacggtcgg gatagcggtg tgtcagaccg ggtaccggtg aatcttcatc ctcatgaagc 1868101 gggtcttcca gatcgtattt tgttttgtgc atttcttcag aaagcggcac agactgcatg 1868161 cgtaccgggc atctcggatt gtcggggtcc attaaagaag catagtaagg tgtaatattt 1868221 aaggggatcg ttttggtaga aattctgacg ccttcctctt catcctcggt cagattaatg 1868281 actttcttta aatcatctaa cgttcttaca gtgtgtgtca gctgccaaag ccaatcgttc 1868341 catttctctt ccggaacgtc cttccataac tcgatctcct tccaatgccg tttcggttta 1868401 taccatttgt ttttcaaacg aactcctcct cgcgcatatt ttgacttaca gttgcttgca 1868461 ccaaatattc atgttttcaa ggccttcggc tataaagcaa ttattgatca gccttccgcc 1868521 atactgataa cctgaatggt acaacacagc attcatccca aaagacgaag cacgggcgag 1868581 agaaaacaca tgaacgatat cctctccagc catttctttt tctaacgcct cgattaaaaa 1868641 gcttgttaac gaatggccgc gatattccgg cagcacagcg caatcggtta tttctgcatg 1868701 cccaagctct ggattgattt ctgcgcttgc tgcgctgatc aggcggtcat gatcaagcat 1868761 gatataatac accgtatttg cattcatcgt cttttcaata taagcggggt caaataccgg 1868821 ggttgggtac gtgcggaata cttttttata cagcatcgat agctggtaca tgtcgtttgt 1868881 ttctgctttt ctcatcgtaa aaacgggtgt actgtcgttg cgaagacggg gcgctgtgcg 1868941 atatatggct tcgatgatct cctgttcctc tgtataagaa tctgtttgtc tccggctttc 1869001 tgaaaggtaa cgtaccatga cacaagccga atggccgaga taatagccct ttagatagcc 1869061 ctccggcgca aataattgtt tggcaaggat cggctcatca tgctgcttcg catagacaat 1869121 gattttttct gcattctctt cttttgccgc tgccacgata tccggcaggg ccttctcaat 1869181 ggctccgtca taacgaacca ctctgattcg tttattaaag ccgtcatggt ccaaaactgc 1869241 tgtgacaccg ctactcttta ttgacttgag catccgcatc ctccccatct gtatgaaggc 1869301 cgcaccaatc catgacaaaa agtgcaataa ttttagcaga ttctatcatg gcttcaacct 1869361 caatgtattc attggcctga tgagccgttt ttgtttcccc cggcccgaaa acgatcactg 1869421 gtgtatctcc tgcatggtac aaaagccctc catccgttcc ccacggggaa gcctcaataa 1869481 tcggctctgt ctgtttcatt ttttgatagg ctgattgcag cacagaaatt aaagggtgat 1869541 catcaggtaa atcattcggc agccattgag cgccaaacca ttcgacttgt acgggatggc 1869601 gtttaaacca ttcgtcatgg tattctaaat ccttcagcca gttttccaat tcaagtttta 1869661 cagcttctgg tttctcatgg ggagcaattc cgcatctccc ttctatgacg acacggtctg 1869721 caactgaaga tggccaggca ccgcctgaga tggtgccgat attcaccggt accggtattg 1869781 ggatattgtc atacagcgga tctgaaattc tcgcattgcg gactttctcc agctcttgta 1869841 tcgctgtgat aacgtgcatg cttttttcaa tcgcgcttac cccttcatag cgtgtgcccc 1869901 catgtgcgga taatcccttc acagtgatcc gaaaccacat cgaaccctgc tgcttaataa 1869961 atagtttcat attcgtcggt tcaggaatca gcgccccgtc agcacgatag cctctcatga 1870021 tggcggaaag tgtaccggcg ccgccgcact cttcatctac aacactctga aacaatacat 1870081 ctcccttcag tttgacatcg caggcgtgca gggcttctaa agcaaaaaga agggctgtat 1870141 tgcctccctt catatccgtt gagccgcggc cgtatatttt accgttttct tcgacagctt 1870201 gatacggttc atacttccaa tcctttacgc ttccttcagg cacaacatcg atatggccgt 1870261 tcaaaatcag ggacctgcct ccgccggctc ccgttttttt agccacgata ttcgggctct 1870321 catgaaaatc ggatcggtta gatttaaagt agggatgctg ttttaattgc tttatgcttg 1870381 gctcccatac atcaatgtcc atatgaaatt gccgcagctt ttcaagcaca acagcttggg 1870441 cgttaaactc tgaccccaat gtgctttttt ccccaatcag ccttttgaga agacgaatgg 1870501 ctttggccga atgctgatca agccactcga ttacttttct ttcaatgtct tgcatcctca 1870561 ttccccctct taagaaaaag gcatatctat tttgatttca gcttctgtca gcctcgtcac 1870621 ctcatcgatt gtcgagccat tcatcagctc ttttaaaatg aagtgatggc tatcgacctc 1870681 aagaaccgct ttttcggtaa taatcaaatc tacacagcct gcagcagtta atggcagcgt 1870741 acatctttct gttaatttag gccttccctt ttgatctgta tgactcatga cgacaaccac 1870801 ttttttcgct ttttgggcaa gctccatcgc cccgcccata ccaggcacct tttttcccgg 1870861 aacaagccaa tttgccaaat ctcctgattg gctcacctgc agggcgccta aaatcgtaat 1870921 gtcaattttg ccttttctga tcatcgcaaa agacatggtt gtatcaaaat aagaagcccc 1870981 ttttacagcg cggacaggat atcccgcggc gttgcataaa tgcgcatcct cttctccctt 1871041 ttcgggactt tctccaatgc caaggacacc gttttccgct tgaaacatga cctgcatgtc 1871101 aggcttcaaa aagttcggta ccaaggaagg gataccgata ccgagattca caatcatgcc 1871161 ctgcttaatt tcagtagcag cgcgttttgc aatctgttct ctttctgcta ctcccaagcc 1871221 catttccact tcactccctc gcttcgtaca accccctcaa caaaaacccc cggtgtgaca 1871281 atcatttctt cagaaatctc ccccatcgga acgatacgct cagcttcggc aaaggttctc 1871341 ctggcggcca ttgccataag cgggttcata ttgcgcgcgg ttttgtcata cgttagattg 1871401 ccgaattcat ctgcaatgta agcattgatg aaagcaaaat cagcagtcag cgcctcttca 1871461 atcaagtatc gttttcccgc cactgttacg atgtcctttt tttcgcaaac catttgatta 1871521 tcaatgccca cgtcggttaa aataccgcca agccccgctc cgccggcgcg aatccgttcc 1871581 gcaagcgttc cctgaggtga aaattgaacc tctaacgtcc cctctgtcat ctgttttccg 1871641 gctactggat tggaaccgat atgcgaggcg atcagggttt tgacccgttg attaacaata 1871701 agcgggccga ttccgatatc cgggaaaccg gcgtcattgc aaatcacagt caaatccgtt 1871761 acaccgctgt ccaatatcgc ttcaatcaat gaaggaggcg acccgactcc cccaaaaccg 1871821 ccaaacatca gaaccgatcc atcccgaaca tctgcaattg ctgtgtcaat gctgattgct 1871881 ttttgaaatg gcgccattta atgtcaatcc ttttttaagt ttttttcgac cgctgcaact 1871941 gtttctgaaa aaatagagat aagctcttcc atttcaccgt ctgaaatagt aaaaggagga 1872001 gcaataatga cagcatctcc ttctccactg tctattccag ctttggaagg ataaacaatc 1872061 agcccgcgtt ttttcgcctc gctgacaata agctgggtta tcgcctgctc tggcggaaac 1872121 actttcttcg ttttttggtc tgccacaaat tcaatgccta atagcagtcc ttttccgcgc 1872181 acctcaccta taatgccgct ttgagatgcc gcctcatcaa gcttcttctt cagcacagcg 1872241 cccttttttt ctgattgttt gatcaagccg tgctttaaca catatcgcaa aacttcaaga 1872301 gcagctttgg ctgaataggg atgtgcacta tatgtgtgac cgctcataat cacacctgac 1872361 ccttgtttta tggtttcaat aatagaatca gatacgacgg cagcagcaat aggtgcatac 1872421 cccgcaccga gtcccttccc cagtacagca atatcaggta cggtatccca atgctctgtc 1872481 gcgagcatcc ttcctgttct cccaagcccc gtcatcactt catctgcaat aaaaagcaca 1872541 tcgtgtgtgc ggcatacctc acttaatctc tcataatatc ccggaggcgg agtaatcgct 1872601 gctcctgcag caccaataat aggctcagcc acaaagccgg cgatgaattg gcttccgatt 1872661 cttttaatca tggtgtccag ttcatcagct gcagtctgaa caaagtcttc ttccgtctcg 1872721 tgattcagcc gataaatatg tggagctgag atagctggat accgctcaat gagatgggtg 1872781 aaccggtatc tcctttcata aaaaccagac aatgaaagcg ctcccaaagt tattccgtgg 1872841 taactgctcc atcgagacaa aaagatggat ttttgtgttt gctttttttc ctgccaatac 1872901 tgaatggcga ttttcatagc tgtttctatc gcttctgatc cgctgttgac aaaaaaagac 1872961 caattcacat ctccgggcag ctcctgtgcc aagagagcgg ctaattgctc ggcgggctca 1873021 ctcgtaaact gtgagcggta agcaaaagac acctgatcaa gctgttcttt cagcttctca 1873081 gtcacatcac gaactccgtg gccgatatta catgtcaccg cacctgacga gccgtcgaga 1873141 tatttttttc cggtctgatc ataaacatat gaacccttcg cataactgac aaccggatag 1873201 gccgagctaa gctctggctt aatcaaataa ctgctcatgc tcccacctca aaaccccttt 1873261 taccatattg tatgagtgtc caaatggcgg catgacgttc cccgcaaaaa ctttttcaca 1873321 taaaaagagc cttcctaata aggaaggctc ttttgaaatt tcagcatcta gcaaataaaa 1873381 gcggctccaa caataattaa taaaatgaac aagacaacaa ttaacacaaa tgtatttgtc 1873441 ccgcagccaa atccgtaacc gtacccagag tatccataca tgctgttttc atcctttctt 1873501 atcacgatat acgacatttt atgcgggcca agtcccaaat ggtttgtgca aacgcctatt 1873561 tcatgtaagg aaataatgaa atacagtatg cacccgctca tattttttaa acgtcagctt 1873621 ttcgtaaaac tgagttgcac cgtcagtgct tgcagccact aagtaggctg cttccattcc 1873681 tagtgatttg gcgatggaca gcatttcttt cactaagata ctgccgtagc ccttcctttg 1873741 aaactgatct aaaattgcca cttcttcgat tttagccgtt ttctcttgat gatcgataaa 1873801 cagctcgccg cacccaatgg gaactttctg tgcctggtcg ctgtaacaaa caacaagaat 1873861 gattatatct gcttcataga aaggatattt tctttttaat ttttgttcag cgattgcttc 1873921 tccaatataa atggaatcgt aaattttcat aatagaagat ccgtcgctaa gactttttgc 1873981 cgtcccccat gcggttaaag gatgtcccat ctgccccttc cagtcactaa gcttcatgtc 1874041 atatagtagc tcatcctcga cgacaaaacc gctttttaca agtgactgct tcaaaccgag 1874101 cggaaaaaca tgctgcggcg acgcttttaa atggagataa ttcgcatcaa gcagctttgg 1874161 tacggagggt aaaaagttaa gtaaccgctc caatggaaac gtatcatgga gctgaacaaa 1874221 gttatgagaa aaaatttgcg gaagctgcgg atctctgtat acgctgtaat gatcaaacga 1874281 tgccgattca gacgttaaca atatatattg atgttccgtt tttgaataat gtcctgtcat 1874341 gaacgtctcc tttttatgac ctataccttt actctgttgc aatattcaat ttctttataa 1874401 tctcatcgta caccggataa aacggctttc caattggaaa ttgctgaata tttcggaaag 1874461 aagcggagat tggcttctga tgtaaaaaaa acttccttgt tacttgttca ctaatcgggt 1874521 gaaagacgcc gtttagaaac aaaaacggct cgcgttcgat gaaaaacaga cgtcggccag 1874581 gcggattttt gatcaattca gatcgtttcc acgtaatcgg cggcccttcc ggaagcgtct 1874641 ccatctcttc ttttccaatt gtcactatgt cttttctttg aaattgataa aattgaaacg 1874701 catactggtc cacaattcgc cttttttttc cggcttcgat ataaaatatt gcaggatggt 1874761 cagcttcctt tactaaaata taattcggaa tgtttaaaat tttgccaatc ctatattgga 1874821 ataaatatgg gtctggaaca gcgacagtcc gatttagata caaaaaaccc cacttttctc 1874881 caacaggatg ccttacaccc tgatcaaaaa aatacacatt ttgatctgaa ccttttacaa 1874941 aagagccgtc aatcaaatcg gcgggcagaa accgatatgc attttgaaat gaatctgggg 1875001 ttttataggt tgtgtctaat acttcattta tcggcagaaa tggggtaaag ttgttgagtc 1875061 tcgcccaaaa aattgcgtcg ccatgattcc aatgcttcat atcatcatcc cagtagcctc 1875121 caaatttatg gtgaatgaga ttaagtaacg aacggcgatg cataactgag caatgatcaa 1875181 cttgaaaagc ggcctgatca agcactgcat tggcatttct gtagaaatgt gagatttcct 1875241 ctcccctttc gtttacatgt acaacttttt gttttgaata gaccgcctgc gcttcaggct 1875301 tatgtgaaaa ctcttgcacc atacggctca gccgctcagg atgataaaca gtgtcgtcag 1875361 taagatagga aatgtaatcg ccgtctgcaa atgggagcgc actgttaatt aatgtggcat 1875421 aacgggctgt ttttaatcga tctgcaggat gcacgaaact gttatgatat tgaatgcgcc 1875481 ggtcatggag atacttgtga atcaccgcag ttgtttctgc attcgaatga tcatccatga 1875541 taaaaagctc ccaaagatca tgcgtttgct gtatcacgct ttcgatcgct ttttgcaaat 1875601 aatcgggttt gttgtaactt gttaaaataa tagacacttt ctctcccatc tataccgcct 1875661 cccgccgtca aacataaaaa cggctccgca gcaagcagag cctctgtcat catttaaaaa 1875721 gcaccccagc ttacaacact tgagagtgaa acatgagatc tcgtgttatt taacgggttt 1875781 tggaaaataa ccaaatcagt cagaacttct tttacgatga cattttgaag tgtatctccg 1875841 ttgatcaaat tgacttttga aaccggtacg cccagctctt ttgcaaaaac aagctggcgt 1875901 ctgaggtcag atggatttcc ttcagaagac gattgacgta tcagcagaat cagcaaaagc 1875961 aaaataaaat gcagatcatc ttggttttct tctcgatcca cttgtttctc taaatccaaa 1876021 tcatccctct cccttatcct tatctctgtt tcacaatatg tgcgacttcg atttatggta 1876081 taggctatgt ccactccatt aaaaaatcag cattttcctt aaatagatga aaaatagatc 1876141 aggtacggcg ttcgactcat accaaataac agccggaaga atatgaataa cgtgagttca 1876201 ctatcgaata ggaggtgtgt gtaatgagct ctgaaaatgc acagttaaaa aaggatttaa 1876261 ttaaagccgt tttaagccct ttatttccaa ctgcaacaga aggaggagaa aatatggata 1876321 gtaatcttaa agccttgctt gatgctgcca tcgatcaaaa agtagatgaa agtgaaacgg 1876381 ttacggcaga atctatttta gacccttctc ttccggcaag atggattttt gccagaatta 1876441 cgccaggcac tacaatcagc attgtgactg attcaggtga catgatcgga ccggttgttt 1876501 tcgttgcttt cgatcaggtt cacgggatcg tatttgtaac acaggaaagc tccgtcactc 1876561 cggcaggcca agctacaaca ttaattgatg tagacaaagt agaaagcgtt acgttctttt 1876621 cataacatcc gatgaaagtc ttgtatatcc agtcgggata cggaggaata tacagttatt 1876681 ttgatcgctg ggctgaagaa tgttttcaga acactcatac agagtatatg attgcagata 1876741 aacctgaagc agaatctttg atgaagatcg aagcgtttca gccggatttc acacttatga 1876801 tggttggaga ccgcgttcct cacgactggc tgacctggtt aaagggtaag gatatccccg 1876861 tgtatgtttg gctgaccgaa gacccatttt atatggatat cagccttcag gtaattaagc 1876921 ttgctgacgc catattaacg atagaacaaa atgcagctct ctactatcaa gagctcggct 1876981 accagaacgt ctattatgtt ccgataccag ttaaccatcg gctgtttaaa aaaatgggca 1877041 ccgaacattc ctatcattca aatctgttaa tcatcggcta tccttaccct aatcgggttc 1877101 agcttatgaa agaagcggtc catctgccat tcacggttcg ggtaatcggc aaggaatggg 1877161 gaaaatatct gcctaaaaaa gtgctcaaac agccgcatat tgatgtcgtc agcacatggg 1877221 ttccacccga acaggccgtt cattattata atggggcaga catcgtaatt aatgcgcatc 1877281 gtccctatca ttttgctttc aaccaaaata ctatgcgcat caaaaatgcc agttttaata 1877341 accgaacgtt tgatatcgct gcatgcgaag catttcaatt aacagattta cccgcggcgc 1877401 atcctttttc atccattatt tcttatcacg gcatgaacga ctttaaggaa aaagccgctt 1877461 tctatatcaa ccaccctgaa gaacggcaaa aagctgcagc agccaattat aaagagaccg 1877521 tacccgcatt tacgtttgat gagcttcctg caaaactaaa agcgattcat ctggcgcttt 1877581 cttgaaaaat cgttcattgc tatgaacgat ttttttattc atagaaaaaa gcagctgcac 1877641 aagctgcttt ctattctagc cgtcagaacg gtctttcagc ttcctcggat ttacctgttt 1877701 atgaagatca ggcatttcgc cgagatgctg tgcaatttgt tcccacgata caattttgaa 1877761 attttgattg acggcttgtc cgttatcaat attttcgccg tcctgcgcca caaaaatccc 1877821 gtacggatat tttgggccaa gtccgaaacc gagaacatca ataccatccg tgtcactagt 1877881 accgtctatc ttctcgccat ctgtaatctc aaagttggct acatagcgat ttttcccctg 1877941 ccgttcatac attgcatagc tgttatttcc ttgacttgaa gccatgagat atcctttgcc 1878001 atttggtgca taatagattg tcagtccttc aatatcagct gtcaaatgat ctcctgtcgc 1878061 acggtcaaca acctgcccct ttgaccctcc gccgggctca gcgttaaatt tccagatggc 1878121 ctcatcttcc tctgctatgt ataggtttcc gtactcatca tccgcaacaa ggccttcggt 1878181 ctgagaattc aacttaaatt cacgcacctt tttccctgtt acataaccct ttccaccatc 1878241 aacaatttca tactgctcaa attccccttg tttgcctgtc actaatgcgt aaaatgctcc 1878301 tgttttctgg ctgtgataca agctgaatcc ataaacctca gaaatattgg tggaaatagg 1878361 atggttcgga tctgtaatgc ttttcaattt tcctttatcc ccgtctattg catatacttc 1878421 aattgtattt tttccttcgg accggttgga tgcggcagca atatcaattt tttcgccgtt 1878481 caatggaaaa tcatagcgca gatcgacatt attgagcttg ccaaactcat aagaatgaag 1878541 ctgttttccg tctaaatcat acacaacgag ccctgacttc ttatttgttg taatcaactt 1878601 gcttttttcc gggtgttttt catgaaccca aatggccggg tcatctgctg catcatcgcc 1878661 agatgcgacc ggatctgtct ccgtgtgtgc agtcactttg aaatgatgtt cctcattcac 1878721 ataatgagcc gacaccgagg ttgctgtcag gctaagcaat aaacccgcgg cagtgcttag 1878781 cagcattgtt tttggaacct tcatttggta ccctcctctt ttatcactaa cactactatt 1878841 gtaaaatata tacaggtgat taccgtgagg aaaatgaacc tttttttata gggtttctga 1878901 ctcataaaca acttattccc caaagaggtg gtgagatgac tttgccagat ttacttttgc 1878961 ggagcgaaat aaaaatatgt tgaatattta gtacattatt tatttagttt tgtttttccc 1879021 tagttacgtc cgtttttcca ttttctatta aaaaagaaca ctttgtgaca tgatcattcc 1879081 cctaaatttt gttttattgg ttgctttcat taattcgatt acaaagttga acatatgatg 1879141 catggtagag aaacgagagt tggaggataa gccatgccta aacagcaaac agcagaacta 1879201 aaaccatttt tccataacaa aacagtttta gtcactggcg gaacgggttc aatcgggagt 1879261 caaattgtca aacgcctttt gatgcttaca cctaaacagg tgattgtatt cagcaaagac 1879321 gacagtaaac agtatgtcat gagccaaaag tatgcggagg ataagcggct attatttgta 1879381 cttggagatg tacgcgatca cagaagggtg aatcaggtga tgaaaggcgt cgatatcgtc 1879441 tttcacgcgg ctgcgctgaa acaggttccg acatgtgagg accatccatt tgaagcgatc 1879501 cagaccaatc tcatcggcgg acaaaatgtg gtggaagctg ccctttcaca ccgagtgcag 1879561 catgtcatta atatcagtac agataaagct gtatctcctg tgaacacaat gggtgccacc 1879621 aagctgttat ctgaaaagct gtttcatcaa gcaaaccgcc acgtccaaaa caaaggaacc 1879681 ttgttttgtt cggtccgctt tggaaatgtt ctcggttcca gaggttcggt catccccata 1879741 ttatttgaac agatgatgga gggtgaacct ctgaccatca cagacaaaaa catgaccaga 1879801 tttttcatgt caatagacga tgcagctaca ttgacattac aatcggctgc tattacaaaa 1879861 ggcggagaaa cctttatttt caaaatggaa tcactgaaac ttgaagaact gattcatggg 1879921 tttgaagaat atgcatcgca gcacgggctc ccgcggccgg ctgcagtaga agtgggcaag 1879981 cgtccaggtg aaaagcttca cgaagaatta acatctccac atgaaattga atcactgtat 1880041 gaatggggca acctttatgc gatccttcca gagccggaaa aacatcctga ctttcgcaaa 1880101 gtcaatctgc ctgggtatca atcagatcaa gccccgctca ttacgaaaga aagaattgct 1880161 cagattattg aagaattgca tcaagagaaa aaggcataaa aacaagcctg tctatccatt 1880221 aggcaggcct gtttttaaca gtttatttat taaagagatg cagatagctt tcgtatcctt 1880281 cttcttttag cttatgcttc ggaacaaacc gcagcgctgc tgaatttatg cagtaacgaa 1880341 gtccgtttgg ccccggtccg tcattaaata cgtggccaag atgagaatca gcagttcggc 1880401 ttcttacttc tgtgcgaatc atgccgtggc tcgtgtccag tttttcttcc acttcttctt 1880461 caatcggctt tgtaaagctt ggccagccgc attgggaatc aaatttatct ttggatgtaa 1880521 acaatggctt gcctgacaca atgtctacat acaacccttc ttccttatga tcccaatatt 1880581 cattttgaaa tggcggctcc gtgccgttat tttgcgttac ttcatattgc atgcgattta 1880641 atgactttat tttttcttct ttattgtacg ccatttattt agccccccaa tgctcgctga 1880701 taaatcccgc tcgtccggaa cctgtccggt agcgctgata atgtgctgga ttctttttat 1880761 aaaaatgctg atggtagcct tccgcttcat agaaaggttc agcttttaaa atgtccgtta 1880821 caatcggatc tttaaagatg ccgctttccg ccagacgttg cttggaagct tccgcaagct 1880881 ccttttgttt atcattatga taaaaaatgg ctgcgcgata ggaactgccg cgatcagcaa 1880941 attgccctcc ggcatctgtc ggatcgattt gctgccaaaa taattcaagc agtttttcat 1881001 aagggaatac atcaggatga aacgtgattt gaacggcttc acgatgtccc gtcgtttcac 1881061 tgcacacctc ttcgtacgta gggttttcag tatggccgcc tgtatacccg gacaccactt 1881121 tttcaattcc cggctgttcg tcaaaaggtt taaccataca ccaaaaacag cctcctgcaa 1881181 atgtggcgat ttcttttttt tcagacatac tggtgcctcc tttgttaata cgtggtatta 1881241 ttatattata gcatgtaaaa atagaatgaa aatgattctg cttttcaata aaatctatag 1881301 gttttaagca atatgcttat gtaatggagg ttcacaaatt tgaaagtaag aacacagatg 1881361 atgtacgata tggaaacttt actccgtaaa gtctttaaac aaatacgcaa tgaaatcaat 1881421 gaaattttag ataaagagct gtcgcggaat gaattcacca ttcttcgaat ccttagtgaa 1881481 caagggccta aaaaagtcac tgaatttgcg cctattttag aggtatcggc aagccacatt 1881541 acggctgtga ccgatgcgct ggtagaaaag gaatggatta cgagaatcag atcgaaggaa 1881601 gacagacgca tcatccgcat tcatatcact gaagcgggcg aaaaagtcct tcagcacttt 1881661 aacgagaaaa aaacggaata tttctttaaa cgctttgact gctacactga tgctgaactt 1881721 gccacgttaa tcgagctctt cagcaaactt gataaaaaac ggtgaaaaaa agcacatacc 1881781 gatatatagg tatgtgcttt tcgcagtgct tcacttattt ttcagtaaac agcttcattg 1881841 ctttccagcg gccatatcta taatacaaaa atgccgcgca gctgctaaat aaaaaactca 1881901 ttccgattcc aagcccgatt cctttttgtc caagccaagc tgaaaataga gctgtgaaag 1881961 gatacctcaa cacccaaaac gagatcaaat ttaataccag aacctgcagc atcgctcccg 1882021 cggccctgac gattccgttc agcacaaaat taaccccaat aaaagggtag aaaaacgcga 1882081 tccacttcaa atattgttca ccaaatgcga ccgcatcagg ctcactgata aataacctta 1882141 tgaggtattt accaaatacc caaatcataa ccgcaatcac cagcatgcag gaaataacag 1882201 ctatcacacc tagccttgca attgttccca ctcttttttc gtttccgatt ccaatatttt 1882261 gccctgccat actattgacg gccgtaccgg cagccattgc tggaagcgtg atgatgctat 1882321 caagccgctg caccgcgcca aagcctgata ccacgtgatc cccgtatgag ttaacaacac 1882381 tcataatcgc catcataccg cctgtaatca ccatcatctg cagacctgcc ggaatcccga 1882441 gtttcaaaat cagcgcggac tcttcccact tgggcattct cggaatcgag aatggcacaa 1882501 gcttgtgttt gatgacataa aacaacccat acaaaaacgc aatgccctgt gacaaaatcg 1882561 ttgaataagc cgctcccgct attcccatgc ggaacacaga aataaagagc ggcgcaagca 1882621 ctgtattcag tacaacagca aacgcaataa accggagagg tgtcttgctg tcgcccagcg 1882681 cacgaagcac agtactgata aagttataac caaacaaaaa taaaatgccg ataaattgaa 1882741 tctgtaaata cgtctcagca agcggtatca ttgactccgg cgtttttaga agacgcagca 1882801 aaagctctga gagaaaaaaa ccggccgcgc cgaatccgat gcttaggcct gttaataaaa 1882861 caacaaaagc gttaatatac gacgccattc cttttatatc atcttttcct ttttgctgag 1882921 ataaaatggt taacgtcgca ttgttaaggc ccaaaataaa agacagcacg gtcaaaacaa 1882981 tcgtgcttga taccgcggct gccccaaggg cctttgcccc cagtaaattg ccgatccaca 1883041 agctgtctat aaattgaaag gaaacctgca atgcgtttcc gagcataata ggcattgaaa 1883101 acagtacaag ctgtttcagc acgttcccct gtgtaaaatc gtatgctttc atcttttctc 1883161 cttgtgttct caaattttct tcggaccaca cgaaaaaaga gacgttgttt catgtctctt 1883221 ttttcatgac ttatcggttt tttttcggtc tcgcataccg aatgtaaaca ccatcacact 1883281 taggaacaag gcacaatagg aaacattcaa atacatttga tccatatctt cagcagccag 1883341 atgatgataa gcaagccagc cgaagtacag ggaaaatgta aaggataata aactgaaata 1883401 ctggtaaatc cgtttcattt tcagtcacct ctattgttta ggatggtaat aggaaaactc 1883461 aatttcatct ttttctaaat ttatcttatc cgctttgaca tacattccat tcgttaaagg 1883521 catttctgac aaacgcactt caatgctttt atctccgggg tgaacatgga caaatgacgg 1883581 caattcataa aagctgtcca tataatttaa cacaaagcta attggtatac tcaatttccc 1883641 taacgaaaat ttcgtgacat tcagctctac atcaccgttt tttttcacgg tcggctcaaa 1883701 agcgataaac gcatcaatag acgtggaaaa tgccttgatt ttccctgcga catgaacatc 1883761 atcatcaatc tctactttat aatcaagctt gtttgatgct ttgtcgttta aatatgagtt 1883821 aacaaacgca gctaatgatt cttttgtgct tgtcacttga aatccatact cgctctcaga 1883881 tgcatctttc acctgagcct gttcccccgg aagcaaaaca agtgccacaa acccggcggc 1883941 gaggataaaa ttgattgcaa gcaatataaa aaacagtcgc ttccacttat tcatgctgtc 1884001 accctactct ttcggtaatc cttctttttt aatggcttga tagacgcgct ttgcgataag 1884061 agaataaccc gtaccattag gatgaaaatc atcttcctca gaaattcggc tgctgtcact 1884121 tttttgatta aacaaatctt cgatatggac gatttttgca tgtttatctt ttttcagctc 1884181 tttttcagca atatggttcc aatccgtgac gacaccattt atttcattta gttctgataa 1884241 tgtaaacgta aacggattgt acatgctgac ataaatcagc tcagcgtgat cattcagctc 1884301 gcgaatttca gaaatgattt tttcaaagcg cttttcgtac ggtttttccg cttcctgaaa 1884361 cggttcaacg gttaattgca gaaagttttg gcgaaggatt ttcatcaaat cattaccgcc 1884421 aattgtaaaa aagacataat ctgcgtcctt tatgcctttt tgaacctttt tatcttttag 1884481 tttttctaat aaatcatccg aacggttccc ttttacagca taatttttca cgtcgaccgt 1884541 tttgacttgt ttatctgacc ggatagaatc cgccaccttg ccgacatatc cctttccgtc 1884601 gggatctccg actccttctg tcagcgaatc tccgacagcc gctatgacaa tgtgttcttt 1884661 tgttttcgtt tcatgggctt tttgttttcc ctcagatgat gtacgtatgc tcgtacacgc 1884721 agtaagaagc aaaatcaaac tggccatgat tgaaaaaatg cgcagcttca atcttgttgc 1884781 tccttcccat tctactagtg gaaagtgtat catgttttag aagatttgca aatgcctagt 1884841 ctcttagctt acttgagtgt actggctgac ttcacatcgg aaatgatatc atcgtacggt 1884901 gtattctcca ctccattgta atctttcagc accttaccgt ccggacctac caaataaaaa 1884961 gaagattgat gaatcacttg gtcctctccc tccggcttct ttacgatcgc tttaaagctc 1885021 ttaagtgcga actcctcaat ctcactctgg ctgtatcccg tgagaaaatc ccagttatca 1885081 aaagataatg gataatttgc ggcaaatttc ttcagctgtt tcggcttatc gttttctgga 1885141 tcaacactaa atgatatgat gcggacatct atattttcgg ctttcagttt tttttgcaga 1885201 tcggtcatat gagcggtcat tggcggacat atagtttcac aattggtaaa aataaaatcc 1885261 gccagccata cttctccttt taaactctct aaagaaacgt tcttgccgtc ttggttttga 1885321 aatgtaaaag gctccacctc gtaattgagc ggatctttaa tctgctgtcc tccgcatgca 1885381 cacaaaaaca gaaaaatcag cccagccgtt aaccccttga taaccttcat gacatccatc 1885441 ctttccagcc agcataaaaa cgctttctaa aaccgtcctt actgtcccat gtttgtattc 1885501 gatactgagc aaaaaaaatc ctgcatgcct ccccattaac gattacaaag gagggcatgc 1885561 aggtaaaaaa cggcatgtta cgcgttgtgc tttaacacct cttgatgaaa tacagcctga 1885621 taatctgccc acttcatccg ccgcttcata taatgtcgga aagaatacac ttttgccctg 1885681 ctgtttgatg aaaacacttc ttttaagtag aattgcaaat ggtgatgtaa cataaagaaa 1885741 tagtgctcat cttcctttaa tacaggtatt tctgtcactt tcacctgaat cccgtcaccg 1885801 cgtttgaact ctaggctttt gagtaacaag ctatcaatcc tcttttttgt ttttcttcta 1885861 ttatatatga tgccagccgg gctgtctgtc attttgcgcg gttgtgtaaa aaaattagat 1885921 tagcaaatgg aacaagtcct catccttgtt cacctctaca taatgaaacg gttttttgtt 1885981 catccgttca atcagcggcc cataatcggc tttgttctgc agctcgatgc cgacaagagc 1886041 aggtccattg cttttattat ttttcttcgt atattcaaac cttgtaatgt catcattcgg 1886101 cccgaggact tcgtcaagaa attcgcggag cgcccccgct ctttgtggaa aattgacgat 1886161 aaaataatgc tgaaggcctt caaaaatcaa ggaacgctcc ttcatttcct gcattcttcc 1886221 gatatcgtta ttgcccccgc ttaccacaca caccacgttt ttccctttaa tttgatcctt 1886281 gtacaaatca agcgctgcga cagaaagagc tccagccggt tcagcaacaa ccgcacattc 1886341 gttatataat tcaagaatgg atgtacatac ttttccttca ggcacaagga gaatgtcatc 1886401 aacgacagtt tccagcgtcc ggaaggtttc ctcgccaatt tttttaacag ccgccccatc 1886461 tacaaactta tcaattttat caagtgtgac gacatgccca gctttgtttg attcaaagta 1886521 ggatgccgct cccgccggct caacagcaat tacctttgta tcaggagaca cgtttttcaa 1886581 atatgtacct accccagaga gaaggccgcc gcctccgaca cttgcaaaaa gaaaatgcgg 1886641 ttctgtatca atgtcgttta aaatctcgac tgcgagcgtt ccctgtccgg ccatcacatc 1886701 cggatcatcg aacggatgga taaacgtccg agattccgcc tcacagcatt cagcagcgct 1886761 tttatacgcg tcgtcaaacg tatcgcctgt caaaataata tcgataaatc cttttccgaa 1886821 tagttcaact tgagatactt tttgtctcgg tgtagtagac ggcataaaaa ttttcccgtg 1886881 aatgccaaga tgtttacacg aaaatgccac accttgagcg tggtttccgg cacttgcaca 1886941 cacaactccg ttctctgtct gctcgctgga aagctgtttc attttatgat aagcccctct 1887001 gagcttaaaa gatctgacaa cttgcaagtc ttcgcgtttt aaatagatat tgcattcata 1887061 tctctcagaa agtctgtcat tcctctgcaa aggtgtgtga atgacaacgt cctttacgtt 1887121 ttggtgagcc ttcaaaatgt ctttcacttg gatgagagag ttttctttaa gcaacggttt 1887181 catgtacaga ttcctttctt gttttaaatc cctatttaat atgccattat aacatgaata 1887241 ttcaaaaaat aagacaatta tttttattta ataattaaaa aaatacagac tatgtccacc 1887301 acatcttgtg gtaacttctg ttcaaccatt atcctgcaga gccaagaaaa aagatgatcg 1887361 taaaataaag ggtgttttca accaaaaggc atgatataat gaaaccaatt agaaccaaaa 1887421 ggagccaatt gatgaatagt gcaccaaaac tcaatacatt tcaacatcta atcggagaac 1887481 atcaaacttt tctggaagcg aagcgaatcg ccaagcagtt ctcgttatcg gagcttcctg 1887541 tcttaataac aggaaaaatc ggaacaggca aaaatcactt cgcacatgcc atacacttgg 1887601 aatcttcgag aagcaatgaa ccgtttataa gcgtcaattg cagcacccat tcggaagaaa 1887661 cccttattca tgagcttttt ggccctaacg gaaacacagg tgtttttcaa aaagcggtac 1887721 gaggaaccct ttttcttgat gatgtatggc gcatgcctgc ttctgtacaa gctcagctgt 1887781 taaaagcgct tgattcagac acggagaaac cgcgaatgat ctgtgcttct gcagaccgat 1887841 ccgtggaaca tacattcagg caagacttat tctacagact gaacatttta acgctcacac 1887901 tgcccgaatt atcggaacga aaaagcgata ttccgctttt gacacagcat tttctctcaa 1887961 attctggtca gcaattgtta atcgatccct ccgtttttcc cgtgcttgag aagcatgcat 1888021 ttgaaggcaa tgtcagggaa ttaaaaaacg ctgcagatta tatggcggca gtatcaagcg 1888081 ggggaacgat tcagccatat gacctgccgc cgtatattag aggcacgata gacggaaaaa 1888141 cgtcgaagaa aaaagcgaaa ctgcttactt taatggaaaa agctgagttt ttgtttattt 1888201 tggaaacaat aaaagtattg aacgaaaaag gagaacctgc cagcagacgg atcatttctg 1888261 aacacagcaa aaatacccaa acctcgttaa ctcctcagca ggtcagaagc cgtctcgact 1888321 atttggagaa aaaagattat gtcaccaaaa gccgcggacg cgcaggcaca aaaattacct 1888381 ttgagggctt gagctttata gagacgttaa aaaatcaaat gatctagcga tcgaaaggag 1888441 aatgtacttg tttacaatca aagaagagat cgccaatgcg attacacacg gcatcggtgt 1888501 cctcttatcc atcccagcat tagtgtttct aatcatattt gcggctaatt acgggtctgc 1888561 atgggacatt gtcagcttta caatattcgg tgtctctatg ctgctgttat atttgagctc 1888621 caccctgctt cacagcatca cacataaaaa aacgaaggac attttggaga ttattgatca 1888681 tagcgcaatt tacgtactca tcgccggaac ctacacgcct tttttgcttg ggccgctgaa 1888741 aggcacactc ggctttaccc tgttggttat cgtatggtca cttgccctag gcggaatcgt 1888801 ttttaaaatt ttctttgtga aacggtttat cctattgtca accttcgtgt atttagtcat 1888861 ggggtggctg atgattattg cagttaaacc tttatatgct tcactgagcg gagcgggatt 1888921 cagcctcctt tttctcggcg gcattttata ctctgtcgga accatctttt acatttggaa 1888981 aaagatcccc ttccatcacg ccatttggca cagctttgta ttgggcggga gcgctgccat 1889041 gtttttctgc gtgctcttct attgtgtaaa ggtgcctttc ctttcgtaac agtaacagaa 1889101 aagcgcagtc ttcacgactg cgctttttta tgcacgtaat tgtttttcat tggcaggtat 1889161 ataagctttt gaaaaggaca attcaatgtc tgccggtttt aagcgtttaa aaaacgagcc 1889221 attttgcatg ttatctgttc ctttcgtttc caccatcacc aacggaagat gatagcgggc 1889281 cgcaagttct acaggatcaa tagaaccatc tagtgaaaga atcaggcttt gtcccttttc 1889341 cagctgtttt gtcacatctt catatacctt ttctgaatcc ccgtctgaaa tcacatccat 1889401 ccgatccagc cattgcccga taaaaggcaa gcggaacact tttgggttag cgataaagcc 1889461 ggccggttcc tcaatatatc cagcaattaa ggccagttca gccaaacgca aacggggatg 1889521 cacatacaaa acaggaccgt gtggtattgg ctctggctga tggatcgtca caactgaacc 1889581 ggagatgccg atacagcctt ctaaaaacgc ctttggctgt tcgtacacaa gagccatctg 1889641 ttttttgtat gacagacggg gatcgagcat tgtttgatta aataattgtt tcatattttt 1889701 taacagcata tacacaatat aaaccactag aaggctgtag cgaaccaatt aaaatcctcc 1889761 cgctttagaa gaattctttt tttcatacat tagaaattcg taatcatacg ggtttttttc 1889821 gtctttggtc ccctgctcag aagaaaccag cttccaattg gattcatcaa attcaggaaa 1889881 gtgacggtca ccctcaaact cgtgatgaat tttcgtcata tacagtctgt ccgcataagg 1889941 gaacaggtcc gtatagagct gagcccctcc gatcacaaag cattcttcag ggcctgaaca 1890001 aatgtccagt acatccttta atgaactgac aaccgtgcat ccctgaaatt ctgaatccgg 1890061 cgctgaggta acgacaatat ttttccgatt tggaagcgga cgtccgatcg attcaaatgt 1890121 tttccggccc ataatgattg aatggcccga tgttattttc ttaaagtatg caagatcatt 1890181 gggcaaatgc cacggcaaat cattgtcttt gccgataagc ctgttggcat ccatcgcaaa 1890241 aatgaatgaa atcatacgct gaccgcccct tttatatgag gatgcggatc ataatcctcg 1890301 atgataaagt cctcaaatgc aaagttaaaa atagaatcaa cctttctggc gaaacgaagc 1890361 tgcggaagcg gtctaacatc tctttccagc tgcaaattga cttgttcaat atgattttgg 1890421 taaatatgaa catcaccaaa cgtatggatg aactcgcccg gttcaagccc agtcacatga 1890481 gcaatgatca tggttaggag ggcataagat gcaatattaa acggcacacc taagaaaaca 1890541 tcggcagagc gctgatacag ctgacaggac agcttgccgt cagacacata gaattggaac 1890601 aggcaatggc acggcggcaa cgccatttta tcaatttcac caacattcca ggcgctgacg 1890661 attaagcgtc tggagttcgg atttgtttta atatcttcaa taagacggga aatttgatca 1890721 atggtttctc catcagctcc ccgccaagaa cgccattggg agccatatac aggtccaagt 1890781 tcaccgtttt catcagccca ctcattccag attcgcactc cgttttcctg cagatagcgt 1890841 acattcgtat ctccttttaa gaaccacagc agttcatgcg caattgattt aaagtggagt 1890901 tttttagtgg tgagcatcgg aaagccttcc cgtaaattaa atctcatttg atatccgaaa 1890961 gtgctgattg ttccggtccc agtccggtct ccctttttct caccatgctc taaaacatgt 1891021 ctgcagaaat ccttatactg tttcattttt ttcatccttt aaaagtagtc ttctagtagt 1891081 gtaacacaat aaaaaatcat ttctgaaccc agaaatgatt tttttatagt cagctgacga 1891141 caggcttttc atcctgttct ttttcttcat cttgcagatc ctgatgcgta tgtgcaattc 1891201 tgctcgccgc tgctgcagca agagctgcca caatatcatc caaaaaggtg tgaataccgt 1891261 ctggactttc atcaagttcc ttaataattc caatcttctc tttatccaaa taaccgaaat 1891321 tggtcaaacc gatcgacccg tacacattaa cgattgaaag cgggataatt tcatctatgc 1891381 cgtaaagcgg ttcatccgtt tcaacaaggt gctgcagcgg ttcggggaga agtttctgtt 1891441 ctgcaagctg atcgagtgca aggcctgtca aaacagcatg aataatttca cgtttgttca 1891501 ggactttttc tacattctcc atgcaaacac tgagcggcag atttggattg tatttttcct 1891561 gaagtttttg aacaatccgt gcaatatctt ctatcataac gccccgtttg ttcagcatat 1891621 cctttgttat atcgaccatt tcattcattg tgtacttttt catgtctaat ggcatctcct 1891681 ttaggcactc atccagttgg gaggcgtgtt gcggtcccag taaatgctcc caagctcatg 1891741 atgtgattga aatccatctt ctgctgtatg ataatgaaaa ttaaaccagt agccgtcatg 1891801 aggcgggtgg tctcttcgca catggaatct gagaagatct tctccagttg tccgattgta 1891861 aacgttgaaa attttttccg ttttgcccgc tgaaggcatg cttgagatca caacatcttg 1891921 gtacgcctca tcatcttgca atgtcgctaa ataatcacta atcacatttt cgatttttgg 1891981 caggatctct ttccgatagt catcctcaat gacaggagcg attctgctgc cgaattttaa 1892041 aaaggactga tcctcagcgc tgtcaaggag ctgttccttg tacgattgaa aaagcagttc 1892101 aggatctcgc ctgtcatccg actcatcatc gtacaggtca tgctcatcat aaaaagcggt 1892161 gtaatcattc tgctcaagac tgctcggctg tccggaaggc ttgtccgcca taagggcagc 1892221 cggaggagat acgagcccga acgttacaat ggtaaataaa accacaaggg tctttctcat 1892281 ccacaatttc atgactgctt attcctctct attttattgt catgtttctc ttattttagc 1892341 acatccaaaa catgcaagtc atgtactata tgaaactgat atgcaaatta ggagattcgt 1892401 tgctatgcac tttgtgtaaa aacgcttaca atatttcatg aaaggaggct ttccgcatga 1892461 ttgacgctct gtttgccaca gtttcactct taacattatt atactttgtc gtcatggagg 1892521 tcaccgatta acagaaagcc cgtgatatga atcacgggct tgtttgaatg acgccataat 1892581 ggaacagtgc tgtttttctt ttcatgacgt taaaaccaaa ctgttcaaac cgcgggcttt 1892641 tccagtggtc ttttagcaca acgctttttc tggcgactcg taccgcttca ttgatacatc 1892701 cttcgtgcaa aacggaatcc tctgccaaat cacgtaaagg cgcgatgccg tcagaggttt 1892761 ctacaggttc atgaaacatt ggatcgaaat aaaccacatc aacagagttg tcagggagct 1892821 gcttgatgtg ttcaaagcaa tcaccattct tcacctggat tcttctcatc gcagcttgaa 1892881 gctcttctat acccgtttcc catgaatgca gccccgtcct cactaaaaca gacacaagat 1892941 ggtttttttc aatcccaaca acagaacccg tttcgcctac tgccatactt gcgataatgg 1893001 catctgaccc caacccgagt gtgcaatcta aaaacgtatc cccttcagat aagccggcag 1893061 cccgaagcat aggttctttc tccccctgta agaagcgttt ggctctgaac atcgctgtat 1893121 tcggatgaaa aaagaatttg gcaccttgtt tcgtatacag ctcaaaccgc tctttgccga 1893181 ccacaagcaa atcacgttca gctgatttca gcaggtgctc aaccgtttgt ttattccggc 1893241 cgcagtatgg catatttagc tctttagaaa gctgctttgc agtttttatg gtgtgttcag 1893301 acggtctata gcttgttgtt atcatcttct gtactcccaa aaagaaaatg cccggagaac 1893361 gggcatttag cagtgcgcat cgaaggcagc agtcagattt ttcatgattt cttccatatc 1893421 gtgtccttca atttcatgac gcggaataaa atgtacgact tctttgcctt tcaaaagagc 1893481 cattgatggt gaagaaggct cctggccagt aaaatactca cgcattttcg cagtagcttc 1893541 tttatcttgg cccgcaaata cagtcaccgt attgtcaggt gttttgtcat tctggaggac 1893601 tgcctgtgta gccgcaggac gcgcaaggcc tgccgcgcag ccgcatacag agttaacgac 1893661 tacaagagtt gtgccctctg ccttttccat aaagttttct acttcttccg ctgttgttaa 1893721 ctcttcaaaa cctgctccag tcagctcgcg gcgcatcggt acgacaagct ggcgcatgta 1893781 ttcttcataa gccattgaca taaaaaaagc cccctctagt atccttcatc tgaagtaaag 1893841 gatactatag agagggccgg atttcaaatg ttcacgcctt aaaataaaag aaagtgtccc 1893901 cagctatcta gattttcata ataccgccgg tgttggcact tgtcacaagt ttagaataac 1893961 gtgccaggta gccggttttc actttcggtt caaaaccttt ccagttcgct tttcgttttt 1894021 cccactcttc ttctggcact tgtacatcca agatgcgttt ttcaatatca acgataatat 1894081 ggtctccgtt ttcaacaaag gcaagcggcc cgccctcagc ggcctcaggt gatacgtggc 1894141 cgattgagag gccacgggag gctccggaaa aacgtccgtc cgtaatcaat gccacttttg 1894201 gcccgagtcc cattccaacg atttgggatg ttggcgccag catttccggc atgccaggtc 1894261 cgccttttgg cccttcgtat ctgatgatga caacgtcgcc ttcttttact tttcggttga 1894321 taatgccgtc aagcgcctcg tcctgagaat cgaatacgac agccggccct tcgtgtcttg 1894381 taatcccatt ctgtacgccg cctgttttaa tgatagcgcc gtccggagct agattaccga 1894441 ataaaacagc aaggcctccc ttttcagtga atggttgatc cagcgggtga atgacgtcat 1894501 aatcctttac ttcatgtccg gcaatggttt ctccaagagt ttttcctgta acagtcagcg 1894561 catctaaatg aagcgctcct tctttcttcg aaagctcatt cagagccgct gaaacgccgc 1894621 ccgcttcgtg aagatcttca ataaacacat ccgatgcagg cgccagctta gccaagtgcg 1894681 gcacgcgctc agcgacttcg ttaatgcgtt ctaaagagta ttcaacgccg gcttcgtttg 1894741 caagggcaag ggtatgaaga acggtatttg tagaacctcc gagcgccata tcgagtgcaa 1894801 acgcgttatc aatcgctttt actgtaacaa tatcacgcgg tttgatatct ttgcgaatcg 1894861 tttccattaa ttgcgcagcc gattttctca caaactcttt gcgttccgga gatgttgcca 1894921 gaatggttcc attacccggc aaagcaagac caagtgcttc tgacagacag ttcattgagt 1894981 tcgccgtaaa catgcctgag caagacccgc acgttgggca tccgaactgc tctagttctt 1895041 gaagctcgtt ttcgttgatt ttccctgctt ggtaggcgcc taccccttcg aatactgagg 1895101 aaagggagat ttttcgcccg tcacttgttc ttcctgccgc catcggtccg ccgctgacaa 1895161 aaatcgtcgg aatgttgatg cgcattgccg ccataagcat tcccggtgtg attttgtcgc 1895221 agttcggaat acagaccatt ccgtcaaacc agtgtgcgga tacaaccgtt tccacagagt 1895281 ctgcgataat ttcacggctt ggcagcgaat atctcatacc gatatgcccc attgcgatgc 1895341 catcatctac cccaatggta ttaaattcaa acggaacgcc ccctgcttct ctgattgctt 1895401 cttttacgat tttcccaaac tcctgcaagt gaacatgacc gggaacgata tcaatgtatg 1895461 aattacacac cgcaataaac ggcttgccga aatcctcttc ttttacccct gctgcacgaa 1895521 gcaaactgcg gtgcggagct ctatcgattc cttgtgtgat catattactg cgtaattctg 1895581 ccatggtgat cctcctaaat tctttcaatt gtttgattgg attttatttt gacaattttc 1895641 agtttattta tgggctgttt ttgcaaataa gataaataca ggccgccctc accttgtttt 1895701 gttctttcgt gtttttatat ttatatagct ttctttcgat ttgaaccctc caactattaa 1895761 tattgttact tactataaat agttttcgga tatttttcaa caatattcga aataattttt 1895821 ataaaaagtg aattcacata aaaaaggtgc atgatctgca ccttttttat ctttattcgc 1895881 ctttttttct gctttccgtc atttgtttcc aaacagaacc ttttgcttct tctccatgct 1895941 caatacgttc aagcgccatt ttgacttgaa ggctgacctc aaattcgggg tcatcttcgg 1896001 cagcgcgcaa agcttcaatt gcactttcat cgccgacttc gtacaggaac atggcggcac 1896061 gccagcgaac aagcttgctg gagtcgctta atgacttgat catagcagga atggcttgag 1896121 gatcgccgat atcagacagg cagtctccgg ccgttcttct gactgataca gctttgtcct 1896181 caagtgcttt atacaataga ggaagaacat caggtgtttc aatcattcct aagtacacaa 1896241 cagcctgtct tctgatggac acctttggat catccaatgc cttctgtaaa accgggatat 1896301 cctcttcttt cggatccatc tgttccaagt gtgcataacg ctttttccag tcctcatcat 1896361 ccagcatatc aagcgttact ttatacgctt tgcgctgtac agcttgtttt gcttcgccct 1896421 ttccttgagc ggctgcttca gtcagtcgtt tcagccgttc atcactgtat gccgcttgaa 1896481 gctcttctgt cacatcatgg ccgatttcat caaagtcacc gaatctgaca ccttgttctt 1896541 tccaagcccg ctcaaacaca acattggaag cttcagatct aagttttaag atcgcctgct 1896601 gaaagcgttc aggtaagccg aagcgttctt cccgctctcc atcggttaat ttaacttgca 1896661 taggaatgcc gctgaacatc tgcacaaaaa cttttacctc tccaaaagat tcttgatcag 1896721 aacgattttc ttctgcgctt tcagcacttt ccatcccaaa tgcagtgcgg acttgcggta 1896781 aaatgtcttt ccagtcgtat cttgcattcc gttcaacagc aagaaaatct gcgacgtgat 1896841 ataccccttt aactccatct attttaagga tttccgctat aacaagcggt gcgccttctg 1896901 cttgctcagg tttatagtta ttgcttttgc ccgccggaag ctcttccgtt aagatgactt 1896961 tcattgtatt cgggcttggt gtaggttcaa ttgattttat cttcatgatc gtcctcctat 1897021 agcatatctg tgacttattc tatcatagtc gctccaagcc ttctattacg acgtttcggc 1897081 atcaatcccg ggtatgtctt tttctaattg gcggacaaat tgaagcataa aattgtgtct 1897141 ttcttctgcc agttcccgtg cagtgtctgt attcatcata tctttcagcc gcagcagctt 1897201 atgaaaaaaa tgagcgtagg cgctttgctc atctccataa aggccatgcc cttttgcgcc 1897261 cgcaaacatg aaagctctcg caatgccgac agcaccaatc gcatcaagtc tgtcagcatc 1897321 ctgtacagct tttccttcaa ttgagagcgg ctccttcgcc aatttccccc tgtcccgaaa 1897381 ggacatcctt gttataatat gaatcaccct gtcagcattc tcttttccta ctccgaaaaa 1897441 aacgagctga tcatatactt cgctcacaga aagcctgacc gtgtcaggca gcttcacatc 1897501 aattaaatca tgaaccaaag ccgccgtttc aacaatgaac aaatccgctt tttccttttc 1897561 tccaatatac gctgcaagat ctgctactct tgatacatga tgccagtcat gtccagagct 1897621 ttcgtcagtc aggatagatt gaacccatgt cctgatttgc tctgcctgct tcaattcctt 1897681 cacaaaaaca ccctcttttt attgctctaa tagcttcacg atatcgtctt ccaactcttt 1897741 cggatttgta tttggtgaat aacggccaac gatttctcca tttctatcca ctataaattt 1897801 cgtgaaattc cacttgatcg ccttagttcc cagcatccct ttcgcatgtt ctgtcaaata 1897861 cacaaacagc gggtgggcgt ttttcccgtt tacatccact tttgaaaaca taggaaatgt 1897921 aacaccgtaa tttgtttcac aaaattcctg tatgtcagcc tcttcaccag gctcttggtt 1897981 catgaattga ttgcagggga accctaagat ctccagcccc tcctgctgat atgtatcata 1898041 taattcctgc agctgcttca attgggaagt aaaaccgcac ttacttgctg tattcacgat 1898101 catcagtacc tttcccgcga aaggctgaag tgtcatgtct ttccctgtga ttgtacgtac 1898161 cttcatatga taaatagaca tgtaagtccc tcctatgtcc ttggtgctga ttattttacc 1898221 ttttttaaat cgcaattcaa aatgtaaaca tcaattaaga actcataaga aacctaacga 1898281 tatgagcgtc agttcattat caattcatat ggctcgtttt ttatcttatc attctataaa 1898341 acattacaat tccctcttac atctttgaaa atcattttac tgtgaaacca aaaggcgtgt 1898401 cagtgcgttt tatttaaaga gttttctgtt gtttccccct caacacgtat agatagattg 1898461 aaaattggcg tgaaaattcc tataatgaag aaaattaaac ggggaaataa tggaggtggc 1898521 acgttgccta ttaatatacc aacacacctg ccggcaaaac aggtgcttga aagtgaacat 1898581 atatttgtaa tggatgaaag cagagcattt catcaggata tccggccgca aaaaattatt 1898641 atattaaatt tgatgccgaa aaaaatccaa acagagactc agcttctcag attgcttgga 1898701 aattcgcctt tacaggttca tttcacattt ttaatcccaa gcacacacac gccgaaaaat 1898761 actgcgagag aacaccttga cgaattttac acgacttttt ccaatatccg tcacaagagg 1898821 tttgacggca tgattatcac cggtgcgccg atcgagcatt tggcgtttga agaggtttca 1898881 tattgggaag agctcaagga aatcatggag tggagcaaaa caaatgtcac ttcaaccttg 1898941 catatttgct ggggtgctca agcaggtttg tattaccatt acggtgtgga aaaaattcaa 1899001 atgccgaaaa aaatcttcgg tgtgttcgaa cataccgttc tttcaaaaca cgaaagattg 1899061 gtaagaggtt ttgacgagct atactacgtg ccgcattccc ggcatacaga tataaatatg 1899121 gaacagcttc aagcagtgcc cgagttaaac attcttaccg catcaaagga agccggggtt 1899181 tgcttaattg tgtctaaaga cgaaaaacaa gtctttttga cagggcaccc tgaatatgat 1899241 acaaatacgc ttcttcaaga gtatgaaaga gatttggaac gaaacctttc tactgtcgag 1899301 gcccctaaac attattttgc aaaaggcagc aacgagccag tgaatcgctg gaaagcgcat 1899361 gccacattat tgtttatgaa ttggctgaat tattacgttt accaagaaac tccttatgaa 1899421 tgggactaat ttttcttttt ttagtgatac gctgagcaaa aaatatgata aaatacatct 1899481 gattcagtct gcgtataaca aaaatttaaa atactggaat ccaaatcatt taaaattagc 1899541 ttaacttttt cactgcatta ataattcgat tatgtatttg tgttatgttt atgtatagac 1899601 aataactcct tacgatgcat gaagcttgct tgttgttgat tacattgagg tgaatttact 1899661 tgaataccaa taaaagagta ttaattttga ctgcaaatta cggaaatgga catgtgcagg 1899721 tagccaaaac actttatgaa caatgtgtac ggctcggctt tcagcatgta acagtttcta 1899781 atttgtacca agagtcaaat ccgattgttt cagaggtaac tcaatacctt tatttaaaaa 1899841 gcttctcaat cgggaaacag ttttatcgtt tgttttatta cggagttgac aaaatctata 1899901 ataaacgtaa attcaatatt tactttaaaa tgggtaataa aagattgggc gaacttgtcg 1899961 atgaacatca gcccgatatt attattaata catttccgat gatcgtcgtg ccggaataca 1900021 gacgccgaac tggaagagtc attcctacct tcaacgttat gactgatttt tgtcttcata 1900081 aaatttgggt tcacgaaaac gtggataaat attatgtggc gacagattac gtgaaggaaa 1900141 aactgctgga gatcggcact catccaagca atgtaaaaat cacaggaatt ccaatcaggc 1900201 cgcaatttga agaatccatg cctgttggcc cgatatataa aaagtacaat ctttcaccaa 1900261 acaaaaaagt gcttctgatc atggcaggtg ctcacggtgt attaaagaac gtaaaagagc 1900321 tgtgcgaaaa ccttgtcaag gatgaccaag tgcaagtagt tgtcgtgtgc gggaaaaata 1900381 cggctttaaa agaatctttg agtgcgcttg aagcggaaaa tggtgacaaa ttaaaagttc 1900441 tgggctatgt ggagcgcatt gatgagctat ttcggatcac agattgcatg attaccaagc 1900501 ccggcggcat tactttgaca gaagccacag ccattggagt gcctgtcatt ctgtacaaac 1900561 ccgtgcctgg ccaggaaaaa gaaaatgcaa acttctttga agaccgcgga gctgccatcg 1900621 ttgtgaaccg tcatgaagag attctcgagt cagtcacttc ccttcttgca gatgaagata 1900681 ccttgcatcg catgaagaaa aacattaagg accttcattt agcaaactcc tctgaagtga 1900741 ttttagagga tatcctgaag gaatcagaaa tgatgaccgc caaacaaaaa gccaaagtgc 1900801 tatcgtaatg gcgtacttga gagcatacga aaatcgtgtg ctctttttat ttatattcag 1900861 ccatcaataa aagcggttac atttttttat ggaacttgcc cttcttttga aaaataagcc 1900921 gtttcgcaac ttgacgggtg ctcccagatg gtgtatagtt gaaccatcat ttaacaatga 1900981 atcaaagtta gatgatgaca aaattttttt tagcacatgg gtgctacagt actaggagga 1901041 attaagcaat atgcaaaacg gtaaagtaaa atggttcaac aacgaaaaag gattcggctt 1901101 cattgaagtt gaaggcggag acgatgtatt tgttcacttc acagctatcg aaggagatgg 1901161 atacaaatca ttagaagaag gacaagaagt ttcttttgaa attgtcgaag gtaatcgtgg 1901221 acctcaagct tctaatgttg taaaactcta aactcaatac atgatgatga gatgacaaat 1901281 agaggagagg cattcgcctc tcctatttga ttttcatctg gatttcaatc gccaaaatgt 1901341 tttgtttaca cctctgttca atctcttcaa catacttttc cattgatggt tttccttttt 1901401 tcgcgatatc ggccagttct tctaaatcac tgtatatttc tataaatgtt ttgtgaagga 1901461 tcaacttcaa gtctttatca tccatagctg cgttcccctt ctctatcaag atacctcaaa 1901521 tagtaaaacg gtcctattta ttctggttca atagttatat cggcttattt ttattttctt 1901581 ttctattttg gtacataaat ttcaaaaaaa ctctgcaaaa taatggcgga ggtgtttttt 1901641 gtgacttcag aatttcataa tgaggatcag accggcttta cggataagcg gcagctggaa 1901701 ctagcggtgg aaacagcgca gaaaacaaca ggagccgcga cgagaggcca aagcaaaaca 1901761 ttagtcgact ctgcatacca agccattgag gatgctagag aactgtcaca atctgaagag 1901821 ctggcagctc tcgatgatcc tgaatttgta aagcagcaac agcagctgct agatgacagc 1901881 gagcatcagc tggatgaatt caaagaataa aaaccgcagc ttctgcggtt tttattttta 1901941 gtgattggtt aagacatctc cgtattgttt caacttttca ccaaccgtac atttattgat 1902001 acaaaatgaa tgcgcataag ttttgccaaa ttctttgcga aactgcttct taataaaaca 1902061 gtccttgcaa tattcatcgt gcagttctgt cagttcttta aagatcattt tcttatccaa 1902121 tatcgtcatc tccgttacgg tctaatttcg tgtggctttc tacgaattga tgggatagaa 1902181 tttttttagc gaggccgtca gcttcctgat tgtcttttcg ttgtattgtt tcgtaggttg 1902241 gagtaagctt cagcgattca aggagtgctt ctattttgtc cagccattca ttatgagatg 1902301 gatcataaca aggccagctg ccgtcaagct gattcagcac aacaagcgag tcccctttga 1902361 ttgtaattga atttctgctt gccccaagct ctcttacttc tcttattgct tcataaagcg 1902421 ctgcgtattc agcttcatta ttggttttca gccggaagct tttatttttt ctcaagcgat 1902481 gccgggttcc tcccaatgaa taatagatga cgatcccgag accggccagt tcgctctctt 1902541 tatcgaaact gccgtcaaaa taaacagtaa tgtcatcagg ctcttgagca agctcctctg 1902601 tcagcttttc caattccttc agcgtccagc tgccgccttt ctcgtcttcg aactctagct 1902661 ccttcatgta tggaaaacgg ccaagttctc tggcgaacgt acgtgcctgc tgtgctgtca 1902721 gccagtcttc gctaaaaaat gagacggatc ccgttccttt tgcttctatt ttcaaatgcg 1902781 gtctgagctt cattacaatc accttaccat tcattagttg ccgggcttat gctataatca 1902841 aaccaatctt accccggaaa ggaagctttt tcatcttgtt taataattcg ttttggatct 1902901 tttttgcgat cattcatttt atcattgttc ttttatttta taaaggattt ggcaaaatgg 1902961 gactgtttgt ttggatcggt tttgcgacag tctgcgccaa cctccaagtc gtcaaaacag 1903021 tcgaactgtt tggcttaaca gcgacactcg ggaatgtgat gtatggcaca atcttttttg 1903081 cgacagatgt gctgaatgaa aaatacggac cagctgaagc cagaaaagcg gtatggctcg 1903141 gattctcaac gctcctgacg ctgacatttg tcatgcaggg cgtgctgctt ttcgaaccgg 1903201 cttccagcga catatcacaa acagcgctgg aaacgatctt cggattcctt ccgcgagttg 1903261 cgttaggaag tctgcttgcc tttatcttca gccaaacgct ggatgtttat gtatattcgg 1903321 caattagaag gatatttcct tctgatcggc ttttatggct cagaaacggc ggcagtacag 1903381 cagtcagcca gttgtttgat acattcatat tcactgcagt cgcctttctc ggcatttatc 1903441 cggcagacgt gtggcttcat atttttattt ctacatattt gattaagttt gcggtatctt 1903501 taatttcatt gccttatgcc tatgcagcca aaaaaatgat acctaatgat gaaaggagtt 1903561 cataatgcct acagaaatat atgtagacgg cgcaagcgcc ggtaatccag ggccttccgg 1903621 tatcggcatt tttatcaaac atgagggaaa agcagaatct ttctctattc caatcggagt 1903681 gcatacaaac caggaagcgg aatttcttgc attaattgaa gggatgaagc tatgtgcaac 1903741 gcgcgggtat caatcagttt cctttcgaac cgattcagat attgtggaac gcgccactga 1903801 gcttgaaatg gttaaaaata taacgtttca accgtttgta gaagagatca tccgattaaa 1903861 agcggcattc cctctttttt tcatcaaatg gataccgggc aagcaaaacc aaaaagccga 1903921 tcttctggca aaagaagcga ttcggctgaa tgaaaagaat taaatcttga tcattggttc 1903981 atcctaatgg cgaggtgaac taacatgaaa aagaaagata aaggccggct gaccggcggt 1904041 gttactccgc aaggcgacct ggaaggcaat acacataatg accctaaaac agagcttgag 1904101 gagagagcaa aaaaaagcaa tacaaaacgc tagagaggat ctaaacgatc tctctagcgt 1904161 tcagcttttc aagcatacgc tcaattcctt taatttggtg gcggcgaagc atgtcagccg 1904221 cctgctccat ttgcaaagta aataaagcgt ctttcagtgt gcaggccagc ggcactgagc 1904281 aatggatttc cgcaagcttc ctcgacatct ccaaatcgct taaaccttgc tgaatttttc 1904341 cctgctgtcc ttttggaaga agagaaagat tttccaataa acggtcaatc gtttcgtatt 1904401 cacgaatcag tttgtaggct gttttttctc caatgccttt gactccggga tagttatcac 1904461 tggaatcacc cataagcgct ttaatatcaa tcaaagcctt cggcattacg cctgtttctt 1904521 cataaaaagt ctcttttgta tagactttat aatttccgat tcctttttga agcaaagcaa 1904581 cgcttacttt atccgttaac agctgaagta aatctctgtc ccctgttacc accgtaatgt 1904641 ccgcttcatt cgcaaataaa tcggcaagag taccgataca gtcatccgct tcatagccgg 1904701 caaagccaat attcatgatt ccaagctctg cggctgcttc ctttgccaaa tcaaactgcg 1904761 gaatcagctc cacaggcggc gcgctgcggt tggccttata atcttggaac aagtcatttc 1904821 ggtacgtttt gctccccatg tcccagcagc agacgacgtg tgtcggctgg aatgtttcca 1904881 cagctgtaat caaatgcttt aaaaagccgt tgacgccgtt cgtcggcacc ccgctgtcat 1904941 ttatcataaa gttgcgatgt acggccgtgg caaaaaaggc ccggaataaa agagccatgc 1905001 cgtcaaccag caatagttta ttattattca tcaaataact cccttttctt tcattccttc 1905061 tattttatca taaagcagcc caaaaataaa aaacagtatc tctttaatta gagatactgt 1905121 ttgaatattt atcaatcgtt gtgtcttttg ttgctggcga tcagcttttc agcttcgcgt 1905181 cctgcgtaag agtcaaaatg ggtttgaaat ccgtttttct ttttggcgtt gttattcgcc 1905241 tgtgcatttc tgtttccgag ctttgttctg cccaacatga atcccccctt acgtcggatg 1905301 catatagtat atgcttccgg caggaggttc actcgcgaca ggatcatcca gcttacatgc 1905361 ggcttacgta ttctctgacc atttcttttg atacaagccg tcttgtcggg acgatgcctt 1905421 ttttagcgag ctgattcatt tgctcggtaa tttcattaat tgcatctgta gtataaggct 1905481 catcgtttct gcatttagca acagcttctt caatcgccaa ttcacgcata ttttcaagac 1905541 gcataaatgc tttgatatgc tcgtgctgtt ttgatgaatg tgctgaaatt gctttatgta 1905601 cctctgacat taatcgttca tctcgctttt ttctatttag tctatcatga cttgaaatac 1905661 aagccaactg aattttacat ttttattgta ttgtctgaat ttttccagga gatgcacgcc 1905721 tgatacgcca tttcaatctc tttcgcatgt tccccttccg catatcctct taaatatgtc 1905781 tctttttgat ccgttatttg cgcgattgct ttttcaccca tatcttcctg taagcgtctg 1905841 aggtgagcag tgtaatgaga tatcaggctt tcttcttcat tttttatcca tgcctctgtg 1905901 attttcgtaa gtttcatccg tacagcttcg ataaaggtcg cttttccttt ctgctcaaaa 1905961 aactgcttcg gtgatttgat ctcttttagt tcctgctcaa aagcacgttc ttctatttcc 1906021 ggttcaactt ccttcaactg tatgccgttc gaatgctgat cacccgcata aacggaaaaa 1906081 taaccgtcct cgtttaatgt tttttgaaaa tgatccagcc attcttcatt gatatgccgt 1906141 tcgatgaaac cgctcatgcg aacatcaagc gttttgattt cctgaatata ttcaaataga 1906201 tattcatgta aggctgttgt catcgcttta ctgacgttct ttttccaatc cccgttttgc 1906261 agcccgggat gaaatgccga ttttaataaa tcatttgcaa aatatgataa tcgctgtgca 1906321 atgtgatata gctgctctct tgtatctttt tttacttttt caatgatggt ttttgagttc 1906381 cgccgtttct cgatatcggc cgctgtccgc tcaaatgaca gcataaggca ctgtttctgc 1906441 gcttccttct cttctcggga ctgatgctgg gattggtgaa gctgaaaaac agtttcgcat 1906501 agtttgtctg cctccgaact gagctgcgct gctgacgctt tttttacatc cacttcgata 1906561 aaccggtcta agtgttttct tactttcgag aactgattat aaaatgactc cggttttccc 1906621 accagttcct ccttacttga tacggtaaag agctgcggct cataaacccc ttcttttaca 1906681 agctctgcgc tgacataatc ggtcactgtt tcgagctctg ttttatcttt tgcaaggtct 1906741 gcagcattaa taataaaaaa cattttatcc atgctgagcg attctttcac aagtccaagc 1906801 tttcgcaaaa atgaacggtc tccttttgaa aaagagtgct gataataagt catataaaaa 1906861 aatgcatcag catctttgat atattggaat gccagttctg tatgccgttt attcatgctg 1906921 ctcgcgccgg gtgtatcaac gatcgtaatc cctttttcag tgagcgggca tgtatagtag 1906981 accgttacct ctttcacagc acaggccgtt gtttcctctg ctacatacgg ctttaattca 1907041 gagagcggaa tcgttaattt cttctgttcc tgtatatact gctgatactt ctcgtatgca 1907101 agcaggaaat tgctgatcaa tttcacgtgt tcttcctgca gcctgttttt tttgactgcc 1907161 ttttcccact tctctgtgaa ggaacggcct gccggctcct ttggtattcc ggtgagctgc 1907221 aaaatttcag ccgttaagtc atcctctgtc ttaaacacta cattcgctgt tttgtttaag 1907281 ttgccattga ttggctttgt gatcttgtta attgtcgctg tggttggcgt tggtgaggat 1907341 ggcagcactc tttcgccgac aagcgcattg gcaaatgatg atttccccga gctaaagcct 1907401 ccaaaaagag cgagtgtaaa tttccgttcc tcaagccttt tcaccctttc acgaaacgct 1907461 gaagtttgct ttaacaacat gctgcattcg cctaaaatgt cagacaaagt gtaaaagcgt 1907521 ttgatttggt cttgaagcgg catttcttgt tccattttga tttctgattt cggcatcggc 1907581 tgcgccgtca gctggcttcg gccttgtttc tgctctggag ccgccactct tgttttcttc 1907641 gatttaaacc attctgtgtc tatatgcatt gggcatgcgg actcttcttc ccaaatggcc 1907701 cacaggcgat cggttttctc tcgggcatta ttctctaaac gtgcctgttc ttgaagaaag 1907761 acaagttttt ctgattcttg gacgagccgg tcgttaattg tttgcacatc tttggaaaca 1907821 cgctctttca ccatagcgga gagcaccttt atgatgtctg cggcttctct tttcgcctct 1907881 ttccggatga gctctgccaa gtcttttgta tattgcaata catattcaga ggaaaaggct 1907941 gcaccatgct tgaccgcgtg ttcaatgatg cttatatcaa gcggtgtgcg ataggcctga 1908001 atcagctttt cactttcagc ggtatagaca tcaaatacct tggcgagttt atgaagcgtg 1908061 tctatcatat gccaatccgc ttcggcctct gttcgttttg ccacatcaga gaaaaaagca 1908121 ttccgccttt tatctctttc ctgtgcagtt ttcgctttag aaaagaaaaa gccggtttta 1908181 aaggaaggct cttgtgattc taaaaatgca gccgccaatt cacgcatttc aaaaggcgtc 1908241 aggttggcgt tttttaaaat acgattgatt tcttcctgca tcctcttctc tgcctcagtc 1908301 atttgttttt cggcctcatc caattgatca cgcagcgatt ggaccagtcc agtatggata 1908361 ttaagctgtt cagcgaaact cggagcgcct gtttcgtctt tcttcagcat ttccgtatgt 1908421 tcctttagca gattacggac tttttgttcg gttaaagcct gcatattgct ttttgattgc 1908481 tgttctattc tgcttaactc ttctctcagg gcccccatct gattgaacgg gtgatccggt 1908541 tctgttactg atgtaaaata gagcgcttcc cttgaaatcc cttcattgca aagcatctcc 1908601 tctacctgcg cttgatagtc tccaaatttc gtctccgtct catcatggcg gtcaatttga 1908661 ttgacgataa aatacacatt cggaatgctt tcttttattg atctgagaaa ctttacattt 1908721 tcctcagcgt gcacgtgatt atagtgaacg acgtaaaaca gcgcatccgc ttggtgaaga 1908781 atagaagcag ccgatagaaa atgcgcatca tctgttgaat ctatccctgg agtatcaata 1908841 tacgcaaccc cggaatcgat ctcagtatac ctgtcaaaaa tttcgacgct ttcaatctgt 1908901 tccccgtctt tacaatattg ctgcaccttg tctttctggt aagtcccttc cagctcagca 1908961 cacgctccgt ctgttgtatg aagccgaact cgcttttccc cgtttctgat cacaacaagg 1909021 ttagcgcttg tcggaatcgg gcttgtcggc aaaatattct ccattaacag gcagttcagc 1909081 agtgacgatt tccccgctga ataatgcccg gtaaacgcga tataaacctc ttcatcagcc 1909141 gcttttttca tgaccgcagc cagtttagca gccctttgtt catcttgatt ctcaataaat 1909201 tgcttataaa gttccccggt tttatgcaaa agctcttttc tgttttgatc tgtcataagt 1909261 ctgaacccct ttgtgccgtt tcaattgtga acctttttcg aaagatctga attcattccc 1909321 ttttcatttt acacaagaat aaaccaaatt tctttaggag aatagaaaaa agccgccatt 1909381 acggcagctt ctataaaaga aaatctgcaa cttttacaag ttccagattc atcaaacaga 1909441 tttattagag attcctttta atacaaaacc aattaataca ctatatgtac aaaccgctcc 1909501 aagcaaaaac agcattgtca tttgcttcac catcctgatt gagaatcttt ttcaaaccca 1909561 ttttaacatg gttgagaatg attttcaatc gctattttac gctgtattcc tgtaatgctt 1909621 tgtcttctgc gcgaattctg acgcttaaca acacggcatt gaaaatggaa aacagacaca 1909681 tggtgacgta tgcttgataa agcagcggaa tcagcaaaat ttcgaggata acaacggcat 1909741 agtttggatg tttcatccat ttatatggac ctttttttac aagctctaca cctggaacaa 1909801 caaggatttt cgtattccaa tatgctccta aggaacaaag cgcccaatac cgtacgatct 1909861 gtacgcttaa aatcactgca gcgataccga gccaccagct ggacggctgt ttattcatca 1909921 gcagcacctc ggcaattaag gacaggaaaa aaaggatatg catcgtaatg atatacggat 1909981 agtggctctc gccaaattca attgctcctt gcttctttac cttttgttcg ttttgcctgg 1910041 ccactgccat ttctgctgct ctttgaacaa tgagaatggc gatcaacaac caaaacatga 1910101 gtcaggcccc cttttcccag ctgaataata gcaactctga tgagaaaccc ggccctaatg 1910161 cgccaatcag tcctcgttca gcttcctttt tatgtccgtt ctgcagatgg tctttgatca 1910221 catacaagat tgtggctgaa gacatatttc cgtgcttttg caaaatgctt tgcgcagatg 1910281 aaagcttttc tgacgacagc ccgagacttt tgatgtatgc atcgatcact ttttttccgc 1910341 ctggatgcgc caaaaaaaca ctgatatcat ggaatgacag cttatgtttg tccaaaaaaa 1910401 tctgtacatt tgttttgagc catttttcca ccaaggtcgg aatgtctcgt gagaaaatga 1910461 ctttgaatcc ttgatcggta aagtcccagc ccatgacatc ttctgattgt ttcatcaaaa 1910521 cagattgggc gtccattatc ttcggcgcaa gcttcagctt tgacaccctg cggtccgcct 1910581 tctctccgca taataaagct gcggcaatgc cgtcaccaaa aagcgaggtg ccgatcagat 1910641 tgctttttgt tttatcttcc ggctggaatg tcaggctgca cagctcggca gaaatgacaa 1910701 gcacaaaagc ctcaggatac gctttgcagt attcggctgc acgcgcaagt ccgctggctc 1910761 ctcctgcaca gccaagcccc caaatcggaa tccgcttcgt atatggagaa aacggaagtt 1910821 cattcataag ccgcgcctcg atactcggtg tggaaagacc tgtactggag acgaaaaaaa 1910881 cagcttccac tttctcataa ggaatggctt cttgaaaaaa ttccggatga gagaggcact 1910941 cacgaacagc cgctctgctg tgtttaagtg tttcttctat gtatatttga tttttttctt 1911001 caaagctgtg cccctcttta taccattcaa tcggcttaac aaactgtctc gaatggattt 1911061 gcccgttttt aaaggaggat aacagcctgt caatatcctt aaaagaatgc tgaaacatat 1911121 agcgggcgaa ctcggccgct ttctcttggt ttacattata cgcaggaaga cttgttccaa 1911181 tggataaaat aaacgccatg cgatcacctc tttgcataca ttgtgccgca acaatctttt 1911241 ttatatgcaa aaaaaactcc gccgcggcgg agttagactg ctgttttttg ttcagcgagg 1911301 tcagcttctt gttctatttt tttagcttta gaaaaaacgt tatatacaat atttaagacg 1911361 actgcagtaa agctgcccgc cacaatgcca ttcgttgtaa gcagcgttaa ggcactcgga 1911421 agctgtttga aaatatccgg cacaacggtc acaccgagcc ccaatcccac tgagcaagca 1911481 acaatcagca gattttcctg tttcgcaaaa tcaatgcggc tgagcatttt aattccgtaa 1911541 gcaatcacca ttccaaacat cgccaccatt gcaccgccca aaacagcgga tggaataata 1911601 gtcgtgaaag cagcgatctt tggaaacagc ccaaatgcca ttaggatcac acctgtgacc 1911661 acaatgacgg catttttttt gatccctgtg agctgaacaa gcccgacatt ttgagagaat 1911721 gccgtgtaag gaaaagcgtt aaaaataccg cccagaagca cagccagtcc ttcagctcga 1911781 tagcctttag acaaatctat ctctgtcaaa cggcggtttg tcaggtcacc taaagcaaag 1911841 taaacaccag ttgactccac aaggctgaca attgcaacga tggacatcgt aatgataggc 1911901 gctgcgtgaa aagacggcgc tccgaagtaa aatggctgaa tcatttgaac aactgccgcg 1911961 tccgaaacat tatcaaattg aacttttccc ataaaatatg cgatgaaggt gccaatcaaa 1912021 ataccgatca aaatcgagac ggacttgata aagccttttg taaaacggta tagaagcaca 1912081 atgatactca acacggtaaa agcaagtgca agattggaga gatctccgaa atctgcactt 1912141 ccttctccgc cggccatgtt attcatggca accggcatca gtgtaatacc gataatcgta 1912201 acaacagagc ctgtcacgac cggcggaaaa aacgatacga gctttccaaa gaaaaatgaa 1912261 ataagaatga caagaatgcc tgaagcgata atgctgccgt aaactgttga aaccccatat 1912321 tcagatccaa tcgctatcat cggcgataca gctgtaaagg tacagccaag cactaccgga 1912381 agcccgatcc caaaaaatcg gttgctccac acttgcagaa gtgtagccac accgcacata 1912441 aaaatatcaa tcgatactaa gtaagtcagc tgctcgacag tcagtcccat tgcttttccg 1912501 acaatcagag gaacgacaat ggcgccggca tacatggcaa gaacatgctg aatccctaaa 1912561 gacagcgttt tgccgaatcc atttctcatg aatgaacctc ctgtacgaag gacacttttc 1912621 cttcttctaa agactgaatt cttgccaaag attccactcg gtagcccagt tttacaagtt 1912681 catctcttcc cggctgaaat gacttttcaa taacaatgcc gattcccgca atagaagctc 1912741 ccgcttgctt cacaatcgac acaagcccgt gcgctgcctg tccatttgcc aaaaaatcat 1912801 cgataatcag cacatgatcc tgatccgaca ggtgggtccc agacactgcg atttggcttt 1912861 ctgtttgctt cgtaaaggaa taaacagacg ctgtcagcaa gttgtcggtg agtgttaacg 1912921 atttatgctt tctcgcgaag acaactggca cacccagctt caagcccgtc attacagcgg 1912981 gagcgatacc tgatgattcg attgtcacaa ttttggtaat accgtctttt gcaaacctag 1913041 acgcaaattc atcaccaatt ctctgcataa gcagcggatc aatttggtga ttcaaaaaag 1913101 aatccacttt caatacctga tcagataata cgacgccttc ttcctctatt ttccgtttca 1913161 gtgcttccat cctgtctacc tccgttatga gaataaaaaa agcattgccc gctcaaataa 1913221 agagcaagca atgctgatat cacaaaaaac cgtacacgtg cggttccatt gctcacccat 1913281 agtcggacat ttacggtgcc cggtagaaac ttgcgtgcca tatccacgcg attatatgag 1913341 tgttcctatt atattgtaat aaattatatc aagattctaa tctcttgcat aggctgaaaa 1913401 taaaaattcc cgaactttaa ttttgttttt ttagatatca ttcgtatttc aaggggattc 1913461 gatataaaag agtctgacga ccgcgccgcc aggcttttga ttataacaga tagagatttg 1913521 aatatttgtt tgataaataa tcaattaaat agcgaacatt cagctcttct cctgttgcat 1913581 ctttaataat gtctaacggc tttttccgtt ttccgtgaat gtgcaccttt tccgtcagcc 1913641 attgctttat cggatggaac tctcctcttt ccaagagagc gtcaaattca gggagatcct 1913701 caagcatttt ttgtttcagc tgagccgcat acatgtagcc gagcgcatag gatgggaagt 1913761 agccgaaatc tccacctgcc caatggacgt cctgtaaaat cccctctgcg tcggtctgcg 1913821 gtgtaatccc taaataatcc tggtattttt gattccaaag cgacggcaga tcttccacag 1913881 acacttcatt gctgaaaatc gctttttcaa tttcataacg gatgatgata tgaagaggat 1913941 acgtcaattc atccgcttcg accctgataa atgaaggttt tgattcattg attgcccgga 1914001 caaaatcatc cagggagatg tccttgaact gtacaggtga tgcctcttga atcttcttat 1914061 agtacggagt ccaaaaatgc ttgttgcggc cgataaaatt ctcgtaaaat aatgattgcg 1914121 attcatgaat tcccatcgat gcgccgtctg acaagttcgt gccactgagt gcttcatcaa 1914181 tattttgctc gtaaatcgcg tgcccgcact catgaatggt cccaaagatc gccgtccgga 1914241 aatctttttc atcatatctc gtcgtgaccc gaacgtctcc ccgattcagc gtagttgcaa 1914301 acggatgaac ggtttcatca agtcttccgc catcaaaatc gtagccaagc tcctgtaaaa 1914361 aatacagact gagctctttt tgcttttctt tcgggaacgc ttttgtaata aagcttgtat 1914421 ctggtttatt tccggaagct gtcacctgtt taacaagagg gataatcgct tccttcagct 1914481 cagcaaacaa ctgatcaagc acctttaccg tgacgccggg ctcaaacaaa tcaagcaatg 1914541 catcataagg atgctcttga tatccccaat acgtaataaa acgtttattg aattcaatca 1914601 gctgttctaa ataaggagaa aacaagctga aatcagattt tcctttcgct tcctcccacg 1914661 ctgtttctgc ctttgaacac agaatcacgt attctttgta ttcagcctca gggattttct 1914721 tattctcttc atactctttt ttcgccagtt ccactgcttt tttcgtatct tccgacaagt 1914781 catcaaatcg ttcatacagg acatcgataa gctccttcat tcgatctgat gtttggatat 1914841 tgaatatatc tgttgaaagc tggccgatac tttcggcacg atcctctgag ccatttttcg 1914901 gcgcgcctgt tctggagtcc cagtgcatta acgcaactgc ttcgctgtaa tgtgagattc 1914961 tttttaaaag atcaaaaaat tctttttcat atgtatgtat ctccatatcc attccctccc 1915021 tattctagcc gttccattac aggctaatgg aagggggtat gaaagtcaaa ttgtttgtat 1915081 aaaaggctgc cggtatgttt tgtggcagcc tttttattca gttgatcgtc atttgatttt 1915141 ttggcggagg tgttctccgc tttttctgct tgattttttt atctacccac actgttgcca 1915201 gcggggttaa gagcgaggtg acaataacgc ttgtcgcgat aattgcagtt gccgactcag 1915261 caactggcgc aaatgaggca ttcgcttccg ctaatgcata tggcacggct acagccgccc 1915321 ctgccgtaga agaagcggcc actcccgcga caccatctcc ccgcgcaata aaacgatcaa 1915381 gcaaaaacaa agaactgccc gataaaatga cgacagaaac tccgataaaa atgccgagca 1915441 gccctgattg gatcagcatt ccaaaattca aggtattgcc gagcgaaaag gcgaaaaatg 1915501 gaatgatcgc cggcacaacc ttgctgaata agtctctgag atcatgatcc agatttccaa 1915561 gtatacatcc aagtaaaaac gggatgactg tcgctgccag cgtttcccat gggaatgcgg 1915621 caagtcccgt cacaccaaac gtcaccatgg tcataaaagg accagattct gtactgataa 1915681 aggcgaaagc gcccgcatcc tcttttcttc ccatgtgatt catgagcgcc aaatacagtc 1915741 cgccgttcgt ttcattcatt accgcgacaa ttgctaaaac agaaaggcct gcaaaaaagc 1915801 cggattgtat gccatcgtca ggtataaatt gcgctgcgat cacgccgagc agcgccgcaa 1915861 atccgatctt ccccaataat aacgtgattc cttttcttgc gatatagcct gaagaacgaa 1915921 aatcaatcgt tgctcctacg caaaagataa aaacacccag tatcggcagc gttccggtaa 1915981 tcaaagcacc cgtaaaccct ccaaagaact ccgctgttcc aggcgcaaac gtgttgagcg 1916041 ccgctccaag aaatagcgga ataatcatca ttccgccagg tacccgttca attgtcgcct 1916101 tgattttcat attgtggatt ctcccatcct ccggttatga aaaaacaatt ccacttacac 1916161 ttggaaaaca gcctgcaaat cctcttttga acagctgccc aactggctgc cgactccgac 1916221 ggcgccagct ccggctctaa gccaatcagg cacttcagac ggatgtatcc cgcctgtcgg 1916281 aataaaggtc acctgcggga aaggacccgc taaatttttc ataaacggaa tgccaaacac 1916341 accgcttggg aacagcttta atgtcgtaaa accgaatgtc agcgcttcca taatttcgct 1916401 cggagtcaag acgccgggga tataatgtgt ctttacaaaa gatagatgtt cagcaagatc 1916461 agctgaaaaa cccggactga caataaactg cgcgccagcc ttagcagctt ccccagcttg 1916521 ctgcgcgctg atgaccgtac ccgcgccaat taaaatatct tccctattac ggaaggattc 1916581 gataatatct gatgccccgg gggtcgtata cgtcacttca actgcacgaa tccctttatc 1916641 taataaactc tcaatctgct gacaggcctc ctgcttatcc tttgaacgaa tgactgcaat 1916701 cagctttgct tctttcagac ggttttcaac gactttggac tccatattaa taatcccctt 1916761 tcttttggtg aaccgttctt tgagcagata aaaaagaagc taatttctcc ctggtcggca 1916821 aaccgtccat atcccccggt gcctgcactt gcaaagcgcc aatcgcattt cccctttgca 1916881 ccgcatcctt gtacgacaaa ccgtctagga taccgctgat tacaccgact gcaaatccgt 1916941 ctccggcgcc gaccgtatca accacccggt cgacccggca gccttctaga aatccttcac 1917001 ttgtccccgt tttaaagtaa gcgccttctt ttccaagttt aatagcaaca aagctggcac 1917061 cttttttcaa ataatagtcg gcaatgcctt caggtgtttt ttctccggtc aatagctctc 1917121 cctctgcgat acccgggaaa aaccagtctg caagcccagc cagatcattg attgtgtgta 1917181 ccattgttgc ttgatcaggc caaagcgaag gtcttacatt agggtcgaat gaaatggtct 1917241 tccctgcgtt tctcatgtcg ttcatgacat gatacgtgaa gtctttcatc tcggctgata 1917301 aagcaggcgg aatacctgtc acatgcaaat ggcctgcgca ttgaaaataa tctctcggat 1917361 attcagctgt agttaatgtg cttgcagctg agtttttcct atagtaggta acttgcgggt 1917421 cgccttcttt cacttttgac ttcagcagca gcccggtggg attttcgtcc tgcgagcgga 1917481 tcacgcggga cacatccact ccctcttttt taagctcttg taaaataaac gttccgagct 1917541 gatcattgcc gaccttgctc atccatccca ttcgaaatcc gagtctggca aggccgcagg 1917601 cgacattgct ttctgctccg gcaagccctt tagaaaaagt ggatacttca tgaaggcctc 1917661 catactcatt tgcataaaac atggccattg attccccgaa tgtcaccgca tcaagcttca 1917721 tctcttccca acctcctctt agttgagggc acctaggatt aaagtgactt tctcatgatg 1917781 acttttgcct ctaattcaat ggtttgaggc gctcctttgt caccttcaat cctttttaat 1917841 acacgttcca tcgccgtcct gcccatatca tgtgacggct gggcgatcgt tgtaatgcct 1917901 ggaccgatca gtttgtacca ctccgtatca tcgaatcctg caatccctat atcttgaggg 1917961 atgcgcaggc caagctcttc catacagctg atgattttca gcataatcaa gccattcaaa 1918021 gccagaatcg cttttttttg ctccggcatt tccttgtgaa aagaacgaag ctccgcctta 1918081 agctgctcct tgtcctttac gtcaatttca tgcaatctga caagcccgtt cacattttga 1918141 accgaagcca tttcctgata cacagctgct ctttctgcac gagggctgat agaggaaatc 1918201 ggttcggtaa acagcgcgac atcagtatac cctttgctgt acaccttctg aagaatctct 1918261 tttgtgatcc atctgttgtc agtcgttacg gtatccagtt tcagatccgg cagtttccgg 1918321 tcaattaaga ttgttggaat ttgctgttca gcaaaagcgc ggagtacatc cttgttttcc 1918381 cctgttgcgt ttaaaatcaa gccctcaacc gaatgggctt ctagctttaa gagcatttcc 1918441 cgctcttttt caggactgtt atctgtgttg cacaccataa tgctgtatcc atattgatca 1918501 caaacctctt cgactcccct gaaagcagcg accgaaaaag gatttgtaat gtcagccaca 1918561 acaaatccga ttaacttgct tttttttatt ttcaaacctt gtgccatttt actcggccga 1918621 taattcaatt ctgcgattgc ctttttaatg tttttcactt tttcaggaga aatcgcgtca 1918681 atttttccgt taatatagcg ggaaactgtc gatttcgaaa ctcctgcaca ttcagctacg 1918741 tctttgatgg ttgtatggcc tgttgttttc tttttcattc aagtgctcct gtatctcata 1918801 tatttgaaac cgatttcaaa accgttacaa caaaagaata ccataatttt aaaatttggg 1918861 aagagttttt ttaataatat gtcaattcat tattttttcg ttgactcttt tcactattta 1918921 tcctaaaatt ttctttgaaa ccgttaccaa aatattttca ttcaagtgat gctgaaatcc 1918981 taaccaaggg ggaaatataa tggaaaatcg ttattctgta catcctgaac aagtaaaacg 1919041 ctttacaaca gaggagcttc gcagtcattt cttaatggat tctttattta cagaaaacaa 1919101 acttacgatg tattactcac atgaagaccg ggttgtcatc ggcggagcgg ctccagggca 1919161 aagtgaactg aagcttgatg caggtgattt tctaaaaaca gacttctttt tggaacggcg 1919221 tgaaatcggg attattaatg tcggccagcc tggtgccgtt agagtcggcg atgatgaata 1919281 tgtgcttcaa acaaaggatt ttctctatat tggaatgggc aatcaggatg tatcgttttc 1919341 aagcctgaac ggggaaaaag cgaagtttta cttcgtctcc gcttgcgccc acaaaagcta 1919401 tccgacacaa aaagccgccc tatctgaact gacaccggac cgccttggtg atgatgcagc 1919461 gtctaatgtc agaagtctgt acaaagtcat tcatcaggat ggcattaaaa gctgtcagct 1919521 gatgatggga ataacgatgt tagatcaaaa caacaactgg aataccatgc cagcacacgt 1919581 tcatgaccgt cggatggagg cttatcttta tctggatctt gaaaaggact caaaggtatt 1919641 tcatttcatg ggccagccgg acgaaacacg ccatcttgtt gttggaaatg agcaggctgt 1919701 cctttctccc gcttggtcta ttcattctgg cgcaggaaca tcaaactata gctttgtgtg 1919761 ggcgatggct ggagaaaatt acacatttac ggacatggat ctcattccaa tggatgggct 1919821 gaaataagat gggttatcta catgacgcct tttcattaaa aggaaaaaca gcgctggtga 1919881 caggcccggg aacagggatc ggtcaaggaa tagccaaagc cctagccggg gctggcgctg 1919941 atattatcgg cacatcacat acaagcagtc tgtctgaaac acagcagctt gtggaacagg 1920001 aaggccggat atttacatct tttacattgg acatgagcaa gccggaagcg ataaaggatt 1920061 ctgcagctga gctgtttgaa aacaggcaga tcgacatcct tgtcaataat gccggcatta 1920121 ttcatcggga aaaagcggaa gattttccag aagagaactg gcagcacgta ctgaatgtca 1920181 atctaaacag cctgtttatt ctgacacagc ttgctggcag gcacatgctg aaaagaggtc 1920241 atggaaagat tattaatatt gcctctctcc tgtcttttca aggcggcatc ctcgttccgg 1920301 cttacaccgc gagcaaacac gctgttgccg gtttgacaaa atcatttgca aatgagtggg 1920361 cagcgtcagg tattcaggtc aacgcaatcg ccccaggcta tatttctact gcgaatacaa 1920421 agcctattcg ggatgacgaa aagcgaaatg aggacatttt aaagagaatt cctgccggcc 1920481 gctggggcca agcggatgat atcgggggga ctgcagtctt tttggcatca cgtgcttcag 1920541 attatgtaaa tggacatatt ttagcagttg atggcggctg gctatcccgc tgacaaataa 1920601 aaaagctgac gaacgatcgt cagctttttt ccattacatc atgtgcggtt caacaggcaa 1920661 gacctttttg acctcatcaa tgatgcgttc attttctccg ccagcgtaaa tgtgaatcga 1920721 gccgctgtct tgattcgagc gaatcaggcg cccgatgccc tgccgtacac gtaacaacat 1920781 atatggcaga tcaacttctt cgaacggatc ttttttcgct ccgttgcgct tcgctgtaaa 1920841 tacaggatcg tgtggcggga acggtaatga ccaaatggta acattcttca atgcgtcacc 1920901 gggaatgtcg agtccttccc ataagtgaac tgaacaaagt actgtttctt cttcctcttg 1920961 gaatttctct actaagctgc tgatttcctc atcaccttcg aagaaaattg gatacggcag 1921021 ctcccatgcc gccgacagct ctttaaactc gtttaattct tcaaaagaag ggaaaagcac 1921081 cagcgttctt cctttgtatc gtttgattgt ttcaatcgtt tcagccgttt tttgttcagc 1921141 gtccatatct gtttttgcgt atagattaat actcatttgc tcgtcataat cataagggga 1921201 atcaacagtt aatgacaaat aatcatgaat cccaagactg tcggcaatat aatcaaacga 1921261 accgccttct gacagcgtag cagaagaaaa gatataagga attttcttag aaaacacttt 1921321 ttcgccaagt acttctgcta ccgttctcgg catcacgaca aaggttgatt ctgcttcctt 1921381 tttctccagc cagctgatcg catccttttg atatagagat aatgaatacg ccatttgttc 1921441 aacatattct tccactactg acagttcgta ttgatcaatc gtatacattt cagactcaaa 1921501 tacaagtgcc tcaccgattt tatcaagtaa acggcaaagc tcgtccgccg cctttttgac 1921561 acgatggtca ttttttattt ctaaacggtg tgaaccggct acttcctttg attcttcaga 1921621 aagaacatag aaaaattcgt cgtttgcgag aagcgcatct tcaatcaatt ctgcaaactc 1921681 ttctctgatg tcattttgca gcaatcgttc taaaaacaat tcaagagtag actgcttcac 1921741 tctataggtt agcgcttttt gcgcagcaaa ctctaacaag tgcccctcat caaatacaac 1921801 tgcactatga tcaggcaaga gcggcagctg gccctctcgt ttgcgtgatt cttccgtcca 1921861 cacatgctcc atataaaaat catgggaaca aatgattaag tccgttgact tgcggtagta 1921921 atctctggaa agtgtcagac cgcatctgtg tctcatatca caagtcagac agtcctgaaa 1921981 cgagtcgtag cttacgtcag accactcttc attcgataga tttgcgtact gcttacggtc 1922041 gccatacgga taaaagcgct gcatcgcctg ggactcgtgg acaaatgacg gtaacgactc 1922101 ataaagatcc agccatttat catcatcaga acgctgcatt gttttttcaa gcttcttcaa 1922161 gcataaatat tgctcatgtg attttgacag ccttgtatca attttcagat caagatgctc 1922221 agccagctta gaaatatcgc cctctttttt caccagctgt tcaattaatg tttcatccgc 1922281 acaagcgatg atggcaggtt tgccgacata ccttgcatag ctgattgcaa aaagaagata 1922341 taccagcgtt ttccccgttc ccactccagc ttcggcgaac atgacttttt tctctttaaa 1922401 cgcccgctcc agctgaaaag ccataaatac ttgctcgtcc cgaagatcaa accctttttc 1922461 gggaaggata tcgtaaaaca cgtcaccaat ccaattgttc aattcttcat aaaaattctt 1922521 tgttttcgtt aaagaaaaag gcaaacgtga tgttgtcacc tagttccaac ccccaactat 1922581 tcgacattca gaccaccaat aatatcattt tccgctgatg aatacaataa aaaacttggc 1922641 aatgccaagt tttttgcagt ttacttacga ttgatcacat gcgacgataa aaaaggatgg 1922701 tctgttgaat aaatatgttc taccgctttt tctaaatcag tttgcgcatg cgaaatcaca 1922761 gacggagacg aatcagtccc gagctccttc agctcgtttg ctgttgcgtc aagcgccctt 1922821 tgaataagat taaaatgttc gctgttcagc atgagatcac ctctgatgga aataatcatc 1922881 attgtatgcg aacttttcat tttatataca tgctttaccg catgttatca ccgaaacatg 1922941 cacaaactac acttgatatt ccgtctccgg attatccgtc ttatcaacaa tattctatca 1923001 gggagtgatg ttgacatgag ttatagaaac cgattagatc agcattctga actgtttcat 1923061 cacaattgga cgcggcctaa acgttcaaag tctcaagtaa acggtcacac tgaaatgtcc 1923121 caaaccaaca ttatattgag aagcaacgcg aaagctcacc gttggtaacg atagaatagg 1923181 gctgaaagat gaaagaagac gcatgcagag cgtcttcttt ttatgcgttt tctgttttct 1923241 tgcgctgcgg tcttactttt gaccagtatt gataataatc cgttttaata aacccgttaa 1923301 agagttttcg tttcttcgtt gcttttctgc catatgcttc ctcaaagttt tcatttgatg 1923361 tcagcatata cacagaccaa gtatcaagcg gctcgaacgc ctgccccatt tctttgtaca 1923421 tctgctcaac ggcttttttc tcgccgagac gctctccata tggcgggttg ccgacaatta 1923481 cgccaaattc cagatttgtg gtaaagtctt tgacctgcat ctgtttgaac tggattagat 1923541 ctcccaatcc tgcttcctct gcattttctt ttgcgatttg aaccatgcgg tggtctatgt 1923601 cgctagcgaa aattgtaagc ggctgatcat aatttgcctt ttcttcgact tcaagccgcg 1923661 ctttgttcca cagatcttta ccgatccatt cccaatcctc tgatacaaaa tcgcggttga 1923721 atcccggggc gatgttttgg ccgattagcg ccgcttctat cgcgattgtt ccggagccgc 1923781 agaaaggatc aacaaacggg cggtcaggcg tccaattggt taattgcacc aaagcggcag 1923841 caagtgtttc tttaatcggc gcaccgccct gatcgacacg gtatcctcgt ttgtgaaggc 1923901 ccgtccctga tgagtccagt gtaatcaaag cctgatcttt caataaagat atttccactt 1923961 tatactcagc acctgtttct tcaatccaat cattggcttt gccggactgc agcttgagct 1924021 tttcgacaat tgcttttttg acgatccgct gacagtcagg aacgcttgca agtgttgatt 1924081 ttaccgattt tccgatgaca gggaatttcc cgttttcagg tataaatgag cgccagttaa 1924141 tcgctttcgt tttttcaaac agttcatcaa atgttttcgc tttaaaagaa gcaacctgaa 1924201 cctttatgcg gtcggctgtt ctaagccaaa ggttcgcacg gcagatggca agtgcatcac 1924261 cttcaaaaat aactttcccg ttatcaacct tgcattcgta tcctaaatct cgtacttcct 1924321 ttgcgacaac agcttcaatg cccatcggcg ccgttgcaat tagtgtatac ttcttcatcg 1924381 tatcaccctg tcttttaaaa cttttctctt ttcaagataa aagctctcct tatacgggag 1924441 agcttgtttt catcatttta aatgtaagtg gtctaacgtt ctgtaagcca tgttttgttc 1924501 catcgtactg caaacggctc atcacctcgt actcaggcgg caatcatcta tctacagaaa 1924561 gcattctgtc cttctctccg ttgaattccg ttaagaaggt tcccctacca aaatttgggt 1924621 ttctcgctcg aggggtttac cgcgttccac tctcaccatt tctagtgaga cttcgtcact 1924681 gtggcacttt caaggatact cagccatatc cgaagacgta ggcttttttc ctgccgtcag 1924741 cctctaaaga ctgccctagc ttatgacttc gctaggcacg aacactacgg gcatctcagc 1924801 accgtgcgag catggacttt cctctacaga ttcaagatct gcagcgatta cccgaacgtt 1924861 aagaacatga attattatat aacaactgat tacaatttac aagcgccatt tttttcaagc 1924921 gtgatcaatc ataaagcttg ctgccaaaaa cgtgtttttc taagttagac agccgtttta 1924981 aaatatcaaa gtttgttgtg ttagattgca caggctgttt tttgctggct tcttcaagct 1925041 gttttttcag ctgcagattt tcctgctgca gttcttcaat ttcttgatgg aaggtttcat 1925101 aatccttaat aatcatatct aaaaatttgt caacgtcttc ttgcttgtag cctctaacgc 1925161 ctgttttaaa ttctttttcc aaaatttctt tcgcagaaag ctttacttta tcagcaagca 1925221 tctttttcac ctcgtatcgt gaatcatcac atatattttt tcagaaatct gtacggttgt 1925281 caaatttctc tctcattgtt agtagctgtc ttcctccact gtcactctca agtcatccat 1925341 tgtaataaag tagatgggat agccatcctg ttcgcgcctt ttttccgctg tcccaagcat 1925401 atacttaggg gagccttcct tttccgggtc atataaaagc agaagcccgt cggacttatc 1925461 aatgaagaac tgattttttt gtttgaattg aagcgggctt tcataaggac ggtgagtcag 1925521 gcttgcttca tagtctgcct gagccagaac tgcttcatac tgttctttat tcggttcttt 1925581 ccagttcttt tcctgctcgt aaaatggtgt gatgacagct acctttaagt cagggtattc 1925641 ctcctgcaaa tcatatgcag cttctgccgc ccacagctca actccaagct ggcccgaaat 1925701 taaaatccat tctaatcctt catccaaaaa agcaatcagc cggtttttaa tggctttttt 1925761 tatgtaatac agcgccttgt catcctgctt aaatatcccc agttcaaacg gtttatagcc 1925821 cgttattgcc aatactttca tcatttcacc tgctttaaaa aatggggctc ccgtgggccc 1925881 catttgttgt gctgcattgt ttacaccatc aagctgcacg ttttccatac tagtagtcgc 1925941 agcaaggttt tcctgcttga aaatgctgat gcgtagccgg gtcaacattt gagaaagtgt 1926001 gtggaaagta gtgaacgtgc tgaaaatgct ggtggtttac gtttgttgta tgctgtgggt 1926061 gaatgtgcgg cacgatagtc ttcgaaaacg tatggtgttc acagcaatga gtaggatgga 1926121 caattggcgc catcatatgc ggtctgcagt gatgcatgat aaaatcccct ttccataaac 1926181 tttattacaa tactaagtta tgaaaaataa ggggtacatg ttctgatgca aagacctatt 1926241 ttaaaagtgt gcaattaagc tgtctttaaa gtttgaaaac acaaaagcaa tcaaaaatac 1926301 cacaacaaag aacaagtaaa aaacaccctt atacatacca actctccctt taaaaataac 1926361 taacgtcatt ttacaggatt cgccgctatt ctacaacaaa atcaatgtga attcagcaaa 1926421 aaaaattcat ggcgaaacaa gtcgtctttt gcgctttccc ggggaatatt taagaggaat 1926481 atttcctctt tagccgggca attctcacat gcagtttttc agtttctttc tctgataagc 1926541 atgccgcatc gctaagcgat tgctctgcta cttgcaatgc ttttccgaat tcttttttct 1926601 tatgctcaaa atatttcgcg agctctatta cagcagcgta tctgcacttc tggttttgcg 1926661 agcgggacag cttttcccaa agcggcactg cttcttccaa gcggttttgt tttttgtaca 1926721 ggagcgataa atccagccgt gcactgtcct ggtcctcaaa cgatttttct ataagccttt 1926781 ccaactgctt gatcgcttgg tccgtttctt tatgagccat aaaccatttc gccatagcat 1926841 aggcttcact gtgttctttt ggcgcatgtg attctgaaag gattttttta gacatatgga 1926901 tgtacaatga aatgagtgat aacacatcca tttcattatg atgcaggaca ccttttaaaa 1926961 gatccggctc ttgcgccttg ataaaatgaa agtaaagcat tggcgccaag tagcccggtg 1927021 tgtcttctag cctgcggatg ccgagctcct ctttttcaac cgtgccaaga gatacacggt 1927081 ccattttgtg tttccacagg cgtctagctc catgcaaaag atcaaagtgg ccaaactccg 1927141 gaagcttcgg aagtctgtca cggatcaagg tgtgccttgt tttcacctgc ggccaatcaa 1927201 aggctttgcc gttgtaggtc acaagtgatg taatgtcaac ctcgcttaaa aagctttggt 1927261 acaaggcgac ttcgttcccc ggtttgggca aaagatgctg tttgactgtc actcggtctt 1927321 catatactct cgcatgccca agcaaaaaaa tggtattccc agctccaccc ccaagaccgg 1927381 ttgtttctgt atcaaagaaa aagaggttgt ttttgttata cccttttgct gacaatgtat 1927441 gcgacaggcc gctttgattc cacagtgtga tcacttcctc aagctcagaa aagctgtata 1927501 acccatggcg gtgagaaagc ggatattcta cttctctgat gaggcaatat tcatcttcga 1927561 agatgaaagg cttcatgcca aaagcctccc actcttctaa aaacgggatg tcatcaaagt 1927621 ggttttcttg tttgcctgct tctatttttt gttctccttc gtcgagcgcc atgtgctttt 1927681 tcatccgttg gagtttccct tttaatgaca tatccggcct ccctccttac gacatttgat 1927741 ccaacagctg caaaattctt tcctttgctt ttatcccttc tatttccgta cctatacaag 1927801 acggacagcc gtcatgacaa ggacaatgtg taatcagttg tttcgccgct tcattaatgt 1927861 ctgaaaaacg tttaaagact tcctccgcca aaccgatacc gcccggataa tgatcatata 1927921 aaaatatggt tggcaatccg gtatgggctg ctttaatttg agaaacaaca tgaacatcat 1927981 ttcgatcaca catgatatac acagggacaa tatgctgcag cacattcgag atgccaagaa 1928041 gcagctgttc cagtgtcttt tccccgatgt cttcatccgc tgttttgatt tcgagccaag 1928101 ctgcacttgt atgcagttct tcttccggca aatgaatagg tccagaccca atattttcaa 1928161 aagtggtcat ttttattttt ttaaaaatgg tcggcagggc attgacagtg acgtctccgt 1928221 agtgcaatga cgtacggctt ttttctttcg ttttatcgat ttctaatacc ttcagctgaa 1928281 ctgccaggtt tgcatccgta taatattcga catcgacttt tctgacatac gcctttttat 1928341 ggtcccaatc gagcttctca acttgatact gaacgccttc atgcaaataa atcgcttcat 1928401 catgcaaaag cgtcatcgca ctaaaacggt ccatttcacc gataatcctt acatttgcaa 1928461 tatccgactg atcaactata acgacatttt cctgggaggc ggaacgcaaa ctgatgtttg 1928521 acgcagggaa cgactcactt gcccaatggt accgttcgcc gttgcggtga agaacagcct 1928581 cttcctgaag atactcaaga atatcactga cttccatggc tccaaattct tcatcagctc 1928641 taaaaggaag ctcataagcc gcacacttta agtggtctac taaaataatc aaattctccg 1928701 gattgattct tgcagattcc ggcgaacgat taaagaaata ttcaggatgc cgcacaatat 1928761 attggtcaat cggtgttgaa ttggctacca tgataatcaa agattcaccg tgtcttctgc 1928821 cggctcgtcc cgcctgctgc caagcacttg caacacttcc gggatacccc gtcattacac 1928881 acacttgcag ctggccgata tcaacaccaa gctctaaggc attcgtactg accactccta 1928941 aaatgtcgcc ttctctcagt cctctttcga tttctcttcg ctctttcggc agatagcctc 1929001 cccgatagcc tctgattgat tttgttccaa tctctttttt cacaagctcc tgaatatggc 1929061 ttaaaataat ttccacccga actctgcttc tggcaaaaac aatggtctgc actttgtttt 1929121 taaggaactc tttcgccagt tcattcactt ctgcggttgc gctccttcta atattcagcg 1929181 gtttgttcac aattggcgga ttgtaaaaca caaaatgctt gcgtccgctc ggtgcgccgt 1929241 tgtcatcgac cagccgcatc ggtttgcctg tcagctgctc tcccaattcc tttgggttgg 1929301 caatcgttgc ggaagtacaa ataaaaactg gatcacttcc ataaaaccgg cagatccgct 1929361 tcagccgccg gatcacattt gccacatggc tgccgaacac acctcgatac gtatgaagct 1929421 catcgatgac gatatactta aggttttcaa acaaactgac ccatttcgta tgatgcggta 1929481 gaatggcaga atgcagcata tcggggtttg taatgacaat atgacctgct tttctcacct 1929541 tttgtctgat tgccggagac gtatccccgt catatgtaaa gcttttaata tcaatgccca 1929601 tttcatcaat aatttcattt agctcgctct tttggtcttg tgccagcgct ttagtcggaa 1929661 ataaatataa cgcccggttt gtttcatctt gggcgatgga ctgcaggact gggaggttgt 1929721 agcataacgt ttttcctgat gctgttggcg ttacggtaac gatgctctct cctttttgca 1929781 catattgaaa agcggaatat tggtgagtat atagttcatc aatgcccctt ttcgaaaggg 1929841 ccgctttgat tctctcgtct atactttcgg gcataggcct tgtttttgct tcccgaggct 1929901 caatttcatg ccaattcaca acgttttcat ttccttttaa atcagaaatg agttcagtca 1929961 gtgatttctt tttcattctt tacacctctt tgtcaagtac agtttaccga atatttgttt 1930021 gcatggctag gtgcaaattt tatacagttg aataaaaaaa gcaaggcata cgccctgctt 1930081 atttcgcttt tattgtaaag agctttgatt cgcctttacg agcagccttt tcgcctgccg 1930141 ataccattga tcctacagcc tcaccattca ttataacgat tgggatgact gtgctgctcg 1930201 ctttttcttt tattaattcc aaatcacatg taatcagcgg gtcaccgacc ttcactttat 1930261 ccccttcttt aatgtgggca gtaaatcctt ctccgttcat attgactgtc tccagcccga 1930321 catgaattaa cagctcaatt cccgagcgag tccgaatgcc aacggcgtgt ttggtgtgga 1930381 aaatctgaat gacttcacct tcagcgggag aaacgatttc accgctagaa ggttccaccg 1930441 ctattccttc tcccatcatt ttctgtgaaa aaacagggtc cggtacatct gacaggtcca 1930501 ttactgtacc gtctgccgga gaataaataa cctcttctgt caccttttcc tgaattttgc 1930561 ccattccgaa taattttttc agcaatgtat tttctccctt ctcattcact tcaaccgtta 1930621 tcccttcatt caccactatt taaccacact ttcaattttg cttcaattta taacaacatc 1930681 tggcatagac gcataatctg gttaaaaaag gcggtggcga tattggaatt ccatgatgac 1930741 aaaaagaacg aactgcaaaa gaaagaagaa atcataacgg aggcaatcga cactcttttt 1930801 caatcctcag cgttcggcaa ccttataaac ggatttcaga acctaatcaa ctcgagttta 1930861 aaggatgtgc agacgaccat acatgtcaga gaaagagata ctgggctgta tatcgatatt 1930921 accattccgg cgacgtttcg agatggcgag atcgtcgttg atgttaaatc gaggtatctc 1930981 catgtaacac tccaagaaaa acagaaacac caaaatgagg ctacctttac aagcatgaca 1931041 agaacggttc agctgcctta tgaagttcgc caagaagata tggaaacgtc ttggaacgag 1931101 cagacaatga cacttttctt tccaaaaaat aagcatgaat gaacgattca ttcatgcttc 1931161 tatcatttaa aaaagctggt aaatcccttt attaaagatc cgacctgatt cattgcactc 1931221 attacttgac ctgtcgtatc catcatttta ttaaaatcaa attgcccatt ggcttttttg 1931281 aactgcgaca taatgctttg aaattgtgaa ggctgctgtt gattaggcct tgggatagga 1931341 taagggttag aaaatacagg cggctgcata ggcataggct ggatcggagc ataaggctga 1931401 taataatcct gctgtccata atgctgctga ggcagttgtt gctctaaata accgggtgca 1931461 gcctgctgat aatatccttg catatgctga ggataataat agcccatttg ccgaggatag 1931521 cttcgagagc tcccgttcat tgcgattccc ccctaaacac aacatatttc tcttctatat 1931581 atgtatgaat gacttctatt gtttgtgtca caagtgatga ttagcatttg tcaaattgtg 1931641 tcgaaagttt aaatttttta aaaacagaaa aaagtcgaat cattatggta ccatattttc 1931701 aatacagatg agaggggatg caccataatg aacgtatcat acttaagcaa acgttttgca 1931761 gaaatgaaga aatatgaaac agactgtatg aataaactga tggactttgc caagttcctc 1931821 tatattcaag gacatctcag cataactgag tttcgtaaca gtatgaaggt tctcgaagca 1931881 aatggagcag aaagcccggc atatgagatg aattaacgtc cggcccccta taaaaacgaa 1931941 aagaagacag ccttttaccg gctgtcttct cttgcaattt catcctttac tgcgtgcaat 1932001 gtataaagga ctgactcagt gatgtccttg aatcgttttt tatgaatatg atgaacataa 1932061 gattgaagga ccaattccag gaaattatcc tttacggcct caatttgctc tttatgcaca 1932121 tattttggcc ggcggacttt tatcaattca agagcaccct ctgcccagcg agcagccagt 1932181 tcatcattct cttcaactgc aggctttatc gtctcaaaaa aatcataaga atgattactg 1932241 ttttttcctt cctgataccg atcagcgcct ttttcagcaa cttcaatcat ttgctcggtc 1932301 atttccagca aagtttgtga tagcaatatc tttcacctca atgcctatcg taccaaattt 1932361 cactcacaaa ttcagccgat gcggtatacc ttctcaaacg catacctgtg ttcaggcgat 1932421 tgatacagct catttataca aatatgaaga tctatgattt cttcttcgag cacacttagg 1932481 cgatcgttct ccgtttcccg catctcagcc tctaatgcat ttacagaatg attcaggctt 1932541 tgctcagctc gcgttaattc atcttctata tcagaaagca tacggagaat atctgtcttg 1932601 catacataac cggacattcg tgtacctccc tttccttgtc tctcccggtt aacattcttt 1932661 gctctcaagg ctctttcctt cctcatgaca aaactagaag caaatcgcca aacaaacagg 1932721 tattccacga aaagctgaag ttttcgacaa aaacacccgc aaaaattgta tgatcctcct 1932781 cattaatgca aacgatactt gtgaggaggt gccgtatgaa aacaagaccg aaaaaagccg 1932841 gccagcaaaa aaagactgaa tcaaaggcaa tcgattcttt agataaaaaa ttaggcggcc 1932901 cgaaccgccc ttctacgtaa gaagcaagga atttccttgc ttctttattt tttcagccac 1932961 tgctccaccg caaaaagcgc atgaagctgg cgctttttat gtaaatacca gtctgtcaat 1933021 tcaatctgct tcggcaattc ctcgcgccta aagaacgttt tctttatctt tccatgaaac 1933081 caatctgttt tcgttccgtc taatgagtgg attaactcag ggtagcatgt ccttagcata 1933141 ggagatgttc tttttgtaat cccgatcatc ttttccatat caaaacggga acctgtgtgc 1933201 ggcactgtgt gcaaaaagtg ataaaaagag gagaacaatt ctggcttgaa cagcaattga 1933261 gacagctgct ttcccagcct tatcctttcc tccgcctttg aaaagcgttt cactgaaatg 1933321 ccgtaaaaaa acccatttga ggaaggaaaa ataacggtgt taaaatgaaa ccagtcactt 1933381 aaataaaaag gaatcgtgtc aaaaacattc tttttaaacg aaggattttg tataataggt 1933441 gtttggatag tgttttgttc atttataatg agggcataca ttagccgctc cgtatttcgc 1933501 tcatgccaaa aacgggtcca ttcttccgac ataaattgtg agacgccaaa cacatgcagc 1933561 agatgaaaca gcggtttccc aactcttttt gaccagtggt ataaaagaag ctgcggatag 1933621 gcatccgaaa aaataagcca gttcgctctt tcataggcta aaaagaacca tttttgctgt 1933681 ctctcacgga gtccaagctg aaacagactg ccttttaagt cagtcattga ccagccggca 1933741 ttacgagaaa cgaaagaagc caaaagcgac catttgattt ccggatgacg gtcgtaaaat 1933801 gctttataag catttgttct tgaaatgtta tccgcgtttt tcatttttgt ctgccgctca 1933861 atccggctca gaagctttct gatggcctgt tgttcttgca cgttcattca cttccgtcat 1933921 gattagttta ataaggagga tgagaaagtg attcggtatc ctaatggaaa aacatttcag 1933981 ccgaaacatt cggtttcatc ccaaaacagt cagaaaaggg ccccgtctta cagtaatcgc 1934041 ggaatgaccc tcgaagatga cttaaacgaa acgaataagt attatctgac aaaccaaatt 1934101 gccgttatac acaaaaagcc gacacctgtt caaattgtaa atgtccatta tccaaaaaga 1934161 agtgccgcag tgattaaaga agcttacttt aaacaatcat cgacaacaga ctacaatggg 1934221 atttacaaag ggcggtatat tgattttgag gcgaaagaaa cgaaaaacaa gacctctttc 1934281 cccctgcaga attttcatga ccatcaaatc gagcatatga agcaggtaaa ggctcaagac 1934341 ggtatttgtt ttgttattat atccgctttc gaccaggttt attttttgga agccgataag 1934401 ctgttttatt tctgggacag aaaagaaaaa aacggcagaa aatcaattcg aaaagatgag 1934461 ttggaagaaa cagcttatcc gatttctctt ggatacgcac ccagaattga ttatattagt 1934521 attattgaac agctttattt ttcgccatca tctggtgcga aaggttgatt aacgaaaggt 1934581 tgagatgtta tgtcagatca atttaacagc cgtgaagctc gacgaaaagc gaacagcaaa 1934641 tcgagtcctt caccgaaaaa aggcaagaaa cgaaaaaagg gcggattgtt taaaaagacc 1934701 cttttcactt tactcattct gtttgtttta ggcgtagtcg gcggtgctgt tacatttgcc 1934761 gtcatggttt ctgatgcgcc gtcccttgat gaaagcaaat tgaagacgcc ttattcatca 1934821 acgatttatg ataaaaatgg aaaagagatc gccgaagtcg gcgccgaaaa acggacctac 1934881 gtctcgatag atgaaattcc cgatgttgta aaagaagcct ttatcgcgac agaagacgct 1934941 cgtttttatg agcaccacgg gattgaccct gtccgtatcg gcggtgcatt agttgccaac 1935001 tttaaagacg gcttcggggc tgaaggcgga agtacgatca cccagcaggt cgtcaaaaac 1935061 tcccttcttt cacatcagaa gacgttgaaa cggaaggtgc aggaagtatg gctttcgatt 1935121 cagctggagc gcaattactc taaagatgaa attttagaaa tgtatttaaa ccggatttat 1935181 ttttctccta gagcatacgg aatcggaaaa gcggcggaag aatttttcgg cgttactgat 1935241 ttaagcaaat tgactgtcga acaggctgcg acgcttgcag gaatgccgca gagcccaaca 1935301 gcgtacaacc cggtcaaaaa cccggataaa gcggaaaaac gacggaacat cgtactcagt 1935361 ctgatgaaaa agcaaggatt tatttctgat tctcaatata acaaagcgaa aaaagtggca 1935421 gtgaaagacg aaggcgtcgt gtcacagaag gaatatgaaa aagcaagtac aaacaaatac 1935481 agcgcatttg ttgaagaggt tatgaaggaa attgatgaaa aatctgatgt cgatccatct 1935541 gctgacggat taaagatcta tacgacatta gatacaaaag cacaagataa actagatgaa 1935601 ttaatggacg gagacaccgt cggatttact gaaggcatgc agggcggtgt gacgcttctc 1935661 gataccaaaa acggagaagt ccgagcgatt ggtgcgggac gcaatcagcc tgtcggaggc 1935721 tttaactatg ctactcaaac taaggcacag cctggttcga ccataaaacc gattttggac 1935781 tacggaccag ttattgaaaa taagaaatgg tccacatacg aacaaattga tgactcagct 1935841 tatacgtatt ctaacggaaa accgattcgt gattgggacc gcaaatatct agggcctatc 1935901 tcaatgcgtt acgctctggc ccaatcaaga aatatacctg ctttaaaagc attccaggca 1935961 gtcggtaaag atactgctgt agactttgca aatggactcg ggcttggttt aacaaaagat 1936021 aatgtaacag aggcctattc tattggcggt ttcggtggga acgatggtgt ttctcctctg 1936081 acaatggcag gtgcatacag cgcgtttgga aataacggaa cgtataatga accgcatttt 1936141 gtaaaatcta tcgaatttaa cgatggcacg aagcttgact taacaccaaa atcaaaatca 1936201 gccatgagtg attatactgc gtttatgatt acagatatgc tgaaaacagc tgtgaagaca 1936261 ggtactggac agcttgcaca agtacctggt gtagaagttg caggaaaaac aggaacgact 1936321 aactttgatg ataatgaagt caaaaggtac aatatcgcta gcggtggcgc ccgagattct 1936381 tggttcgttg gctacacacc gcaatataca gctgccgtct ggacgggaat gggagaaaac 1936441 gaggctggaa agaaatcact ttcagctgaa gagcaaaaag ttgcaaagcg catcttcgcc 1936501 cagctcatcg ccgatgtcga tgacggaagc ggatcatttg agaagcctga cagcgtagtg 1936561 gaagccaccg tagaaaaagg ttctaatccg gcaaaactgg cagggccaaa tacgccaagc 1936621 gataagaagc tcacagagta ctttgttaaa ggcacagctc cttctactgt ttctaaaaca 1936681 tatgagaaag aagaaaaaga ggaaacagct aaactgtctg gtttaaacgt gaaatacgat 1936741 aaagacaatc aatctttaac gttaagctgg aattacgacg gagatgcgac ctttgctgtt 1936801 aagcaatctg ttgacggcgg cagctactcg gaaattcaaa acagctctgc aaaagaggca 1936861 gttatttcgg gtgtgcagcc aggatctgta tacaaattcg aagtaacagc cgtcagtgat 1936921 gatggcaaaa gtacagcttc cacatcttat gaggtgccaa aagctgaaga cgatgaagat 1936981 aaaaaagacc agcaacaaac ggatgatgaa aaacaagatg atgagaagac tcaggatgat 1937041 acacaaactg atgattctca aaaagatgac ggtcagacgg atcaagatca gacagatgat 1937101 tcaacaaacg atcaagacaa aaaacaagac aatacgaaca ccaatccgtc cgacaacaat 1937161 aaccaagacc aatcaaacga taatgataac gacaacagta acaaccagga tacgtcggat 1937221 ggtgattcga actctggtaa gaatgattca acaggttctg acacgaataa aaataaaaca 1937281 gacacatcta ataaaacaca aacaaactca tcatccattg aaaaaacaaa ttaaacaaaa 1937341 aagccgtcac ctttggggtg atggcttttt tggtacacaa taaaaaacct cccgttttaa 1937401 caggaggttt tatcgattca tcgcatgata tttataaaaa tgctttttca tttcggtaat 1937461 cagctcatca agctgaataa agcaatggta ttgggtcggc ttaagaagaa taaattccac 1937521 tcgttcagcc caattaatcg gctttgcggg atatgatttc tccctcagtt cttgccaatc 1937581 gagcgatttc accggctcac ctgctgtcca atgtaacgaa gccagcaaac acacaatgcc 1937641 ctttaacatt tcgttttggt cacatctcga ttttcgtgtt tgaaagactg ggagaagtga 1937701 tgctttgatg tcatcccaca cttcaaataa aagcggaacg tatttcccgc tgtcctccca 1937761 tggcaaatcg ccttgtaatt ccgtgcagaa atcaaaatac acgggattgg tctgcaaggt 1937821 tttcttcata tccgaggaac tcttctggcc aagactgcgc aagtattgct cataggaagc 1937881 caacacttct tttgcttgcg tcatcgtttc accagtcctt ttttatccct cttctgccct 1937941 tctctgcaca aagaaagcag cggacactcc gcacagcgcg gagattgggc tttacagtga 1938001 tatctgccga agaaaataag ccggtgatgc gtaacggacc aatcttcttt gggaaccttg 1938061 cgcatcagcg tcttttcaac ttccagaacc gagtccttcc accggcaaat gcccaatcgt 1938121 ttgctgactc tctccacatg ggtatctacg gctatggccg gcacgccaaa cgcaacggat 1938181 accactacgt ttgcggtctt tctcccgacc cctggcagtt tgacaagctc atcgcggtct 1938241 ctcggcactt ctccgccgta atcttcaata atcattttac tcagcttttg aatatttttc 1938301 gctttattac gatataaacc gattgattta atatcctgct gaagctcttc cagcggaaca 1938361 gccaaatagt cttccggccg tttatatttt tggaataatg ttttggtcac tctgtttaca 1938421 agtgcatctg tacattgcgc agataaagca acagccacca ctaattcaaa aggattggaa 1938481 tgaaccagtt cacactccgc atgaggaaac atgtcaccta tcttgtctaa acagaattca 1938541 atttgtttta gatttaacac gattgtcacc ttttcacttt attgttcaag ccaattgtaa 1938601 aaaggaacct gccttttata ctctttttgc ggttcattct gctttgcttg tacacgccgg 1938661 aatttttggc tgtgtatttt tgcctgctcc acagttttaa gcccattttt cttccattca 1938721 aacaaaatcc ggtcaatgta gcggaaactg agttttcctg atagtacagc ctcttttaac 1938781 gcgtgtttga tcagttgtgc gtcatgctga tcctggtcct gccagatcgc cagcgtttca 1938841 cactccaaag gcgataacgg tcttgcgaac tcttcctcaa aaatggtata aaggcttttt 1938901 tgttcccctt ctgcttttct ttcctgtgtt tgattctgtg caagctgaat atactcgtac 1938961 agcttgcccc ataaaggctg aagagaatat ttctcaaatt tgatgccgtt ttgatcctcg 1939021 cattcttcaa taaacagaaa gcctttttga ataaacatcc gcaatctgtt tgtacattct 1939081 tcaacagaaa ttgacatacc ttcctgcagc tgattcggtg taggaaaata tgatcctttt 1939141 tctaaatgca ttttaatttt taacagcaga ataagttctg tttcattaag cccaagctgt 1939201 ttataatgcg tgagcagaag attggggatg gttgatgttc cctgctcctg catatcaata 1939261 aattgctgtt ttttcatcgt cacacctctt actgtaaagg attgtgattg cccctttact 1939321 gtaaaaagtc tcccttgcag gagactcttt tttgtttcat ttgaatgtat tacggataca 1939381 gacggtttaa cagtcttggg aacggaatcg tttcacgaac gtgaggcgct ccgctgatcc 1939441 aagctactgt ccgctctaat ccaaggccga agccggaatg aggaactgat ccatattttc 1939501 taagttcagc ataccattta taagcgtcag aatccagtcc atgttcttta agacgcgatt 1939561 ccaaaagttc catatcgtga atccgttcag acccgccgat gatttctcca tagccttccg 1939621 gcgcaatcaa gtcagcgcaa agcacaacgt cctcacggtc agaagccggc tgcatataga 1939681 acggttttaa ggacgtcgga tagcgagtga tgaataccgg tttgtcataa tgttcagcaa 1939741 tcgctgtttc atgaggcgct ccgaaatcat ctccccactc gatatcgtca aagccttttt 1939801 ctttcagaaa ttcaatcgct tcatcatacg taattcttgg gaacggggct ttgatttgct 1939861 caagttttga cgtgtctctt cccaatgtgt ttagttcaat tttgcaattt ttaagaactg 1939921 attgcacgat gaaagaaacg taattttcct gtacttgaag gttttcttca aattctacaa 1939981 acgccatttc cggttcgatc atccagaatt cgattaagtg acgctttgtt ttagactttt 1940041 ccgctctgaa tgtcggtccg aaagagaata cttttcctaa agccattgcc gcagcttcca 1940101 tgtagagctg tccgctttga gacagatatg catcttcatc aaagtacttt gtcgcaaaga 1940161 gttctgttgt tccttcaggt gcgcttccag tcaaaatcgg cggatccact tttacgaagc 1940221 cttcgttatt aaagaattcg taagtcgcgc gaatgatttc attacggatt ttcatgatcg 1940281 catgctggcg ctttgaacgc agccataaat gtctgtgatc catcaaaaat tccgttccgt 1940341 gttcttttgg tgtaattgga taatcggtcg cttcgtgaat gacttcaata tctgtcacag 1940401 caagttcata tccaagcgga gaacgctcgt cctctttgac aatccctttt atatagagcg 1940461 acgtttcctg cgtcactgat ttagctgttt ggaaaatgct ttcttccact tccgctttta 1940521 ctacgacacc ctgaataaaa ccggtaccgt cccgaagctg taaaaacgca attttcccgc 1940581 ttgaacgctt attagcgacc caagctccga tcgttacttc ctcacctacg tgcttgtaca 1940641 cttggttgat tgttgttttc aacatatttc cctccaaaac aagaaagaca ttcggaagct 1940701 cattgccccg cgaactcttt tatcatcact ttattatacc cgctcttaac taaccgggtc 1940761 aatgcagata aaaagcggct tttctgtcag ccgctttttg atctgttagc tatgtttttc 1940821 tacaaaacgc ttgattcttt caatggcttc ttcaagaaga tctaacgatg ttgcataaga 1940881 aagacggaca ttctcaggag agccaaatcc ggatcctgga acaatcgcaa ctttttcctc 1940941 ctcgagaagc gctttaacaa attcatctac atctttgaaa ccgcaagatt gagctgcctc 1941001 ttttgcattt gggaacaagt aaaaagcacc ttccggcttc acgcagctga accctgggat 1941061 ttctatgagc tttgcataga tcgtatttaa tctatgttca aatgcttctc tcatttcttc 1941121 caatggctca gaaggcccgt tataagcagc aatcgctccg tattgtgcga ttgatgtcgg 1941181 gtttgacgtg ctgtggcttg caaggttcgt catcgcttta ataatgtctt cagagcctgc 1941241 cgcataaccg attctccagc ctgtcatgct gtgggacttc gatacgccgt ttataatgac 1941301 cgtttgctct ttcagtctgt ctgacagctg tgcaatggaa acatgtttct ttccgccgta 1941361 tgtaagtttt tcataaattt catctgacac aatcaagata tcatgttcaa ggcacacttc 1941421 accgagcgca gatagttctt cttccgtata catgacacca gtcgggttgc ttggagagtt 1941481 aataacgatt gcttttgttt tttccgtaat tgcatttttc agctgctcag gcgaaatttt 1941541 gaagtgattt tcctcaagcc cttctacata aacaggcttt ccgccagcga gtttcacctg 1941601 ctccgggtag cttacccagt aaggcgttgg aataataact tcatcttctt catccaaaat 1941661 cacttggaaa agggtataca gagcatgttt ggcaccagtg cagacaataa tttgagacgg 1941721 tttgtattca atattctggt cgcgtttaaa tttctctgca atgctgtttt tcagttcagc 1941781 caaaccaccg gaaggcgtgt atttcgtatg gccctcgttc atcgaacgca cagcggcatc 1941841 aataatatgc tgcggtgtat tgaagtcagg ctcgcctgct cctaagccga tgacatcatg 1941901 gcctgcggct ttcagttctt tcgctttcgc tgtgattgcc agtgtggttg atggtgttaa 1941961 tgcggatact ctttttgcca gtttcaactt gaactccccc taattcgtct taaggcgtga 1942021 tatttttgag aatctttcca gttgtaaagt ccacataact taaactgtat tgcccttctt 1942081 tgtctaagta cgtcacttcc caaagcagga cgtttccttc tcttgccaga tgaacctctt 1942141 tttgctttga aaccagccct tcatccttta tgattttcgc cgctttgtct tcagagattc 1942201 cctctttcgc ttcttttgag agaatttttg cttttttatc agcaggaacc cagacatata 1942261 atgcagtgcc ttttttatcc gttcccttta caacataata tttttctttt ccgacaaatg 1942321 tttcgacttg atcaacatgg gcgagatcgg tttctttttt agcttcagca gctgctgctt 1942381 cgtgcccctc ttccttttgt gccatggctg atttataaat gcttgccgag acaagaagta 1942441 ctgctaaaaa aataatacca aaaatgacgg taaatattaa tgcttttttt ctcatcttct 1942501 cacctacgta cgataaatgg taaaaacggc ttggtttttg ttttcttcat ccagcgcaag 1942561 gccgaacatc agattgtctc ttttcagtgt acgattcaat gtgtccacaa ttttatacag 1942621 atcatcagaa tgctctacat taattgttga aagaatttcg attttacttt ccattttttc 1942681 atcctccagt ttgaacaaat attgttagtc atactccatt tcaggacacg ccatactagt 1942741 atcacagagc gggaaatccg cttttaaata aaacaccatc ctactcccac accgcaaaag 1942801 ccgctttatg cggcttttat tctttttccc ctgcaacata agcttcaagc tcgctgtcag 1942861 tcatttcgga tactgaggtt gtcggcaagg catcaagaaa cagccggccg taaccagcgg 1942921 ttttaatccg tctgtccaat ataataatcg ttcccttgtc tcccgcagaa cgcagcaagc 1942981 gtccgattcc ttgcctgaag gtcagcacag cttccggtaa tgacactgtt tgaaacggat 1943041 tctttccttt tttgcgggca agctcacatt ttgcagcatg aagcgggtga tcaggggacc 1943101 ggaatgggag cctcacgatc attactgtcg tcagctcatc accagggaaa tcaacgcctt 1943161 cccaaaaatg atttgttccg agcaggatcg cctgattgga tgttttaaaa gtcttcatca 1943221 gtttgccggg acttccgcct gtaatccctt gtgccaagag ctgaatgccg gaagcactca 1943281 tgttatgctt aagctcctgg tgaacctttt tcagcatatc atgggatgta aacagcacaa 1943341 ggattttagg ctgtttttcc tttgccatca gttcgatata acgggctgta tcctgtataa 1943401 attcaggttg ccctgtatcc tgaattgatt tcatttcttt tggaatcatc acctgcatac 1943461 gctcatcgta agaaaagggt gactcaattc tcattgtccg cgggaaaaag tcactcagtc 1943521 ccagtcgttc aatcataaat tgaaaagaac cttcgactgt aagagttgca gatgtcagca 1943581 ccacactatt tttgcgcgcg aaaaactgat cagccagaag ttcaccaggt tcaagaggct 1943641 gtgcgtaaat ggccactgca tttttcgcac cctttgcatc tatttcaatc caaaccgctt 1943701 catcgtcatc agagccaaag aagagcttct gcaacgtctg acagtaatgc tgcaagcctt 1943761 tcatgcttct ttggtattca tcggctaaaa agacggtttt gctcttcatg cccttcaaat 1943821 gtttttccat aagggatgac tgcgcctcaa aaagctgctg caaatgtgtc agcatggaac 1943881 aaagcctctc cgcaccatct gttaagatcg accagctttt atcctggctt tctttgttca 1943941 ccttaaacac tagacggttt aagtcttctt taggttttct tcgtttgaca aaagaatgta 1944001 cagagctaaa gaaagcatca ctttctgctt gaacgtgctg aagccactct tccaattcga 1944061 aaaatgaatc aaccggcagg ctgtttcgct ggaatagctg tctcatcttt tttagaagtc 1944121 cctgctcctt cagagtgccg attctgctca atttcgtatg caattctatg tacgtggctc 1944181 ttttccctaa atgttcgctt gccgcacgtt caaaatggtg tgcttcatca ataataaatg 1944241 tgccgctttc gggaagcctt tttttatggc tgccttcatc ggtcagcaaa agagaatgat 1944301 tggtgatcac caaatcggaa cgcatagcaa tctgtttggc ccgctcgtaa aaaccgatca 1944361 catgctcact gcgacttctt ttataggagt catcgtcata agccaatctg tcccacagca 1944421 attttccgcc tgaaggcaaa ttcagttccg ctacatctcc tgtatttgtc tctgtcagcc 1944481 aaacaagaag ctgtgccttt gtcagtacgg catcataatt atcatcttct tcatgaagca 1944541 cctgctcaaa tttatacagg cataaataat gcgattgccc ttttaaaatc gccgctgtta 1944601 ccggaaatgg aaacagatct tggacaatcg gcaaatcctt tgtgagaatc tgctgctgta 1944661 aaagcgtcga atacgtgctg attatgaccg gcttttttga tttcttggca aaaagcgcag 1944721 ccggaataag atagccaatc gtttttccga tgcctggagg agcttcaatc agcgcatgct 1944781 cacgattggc aaacgcatca gccacctctc tcatcatcat catttggccg tctctttttt 1944841 catacccagg cattaactct gacagcgctt tttcatttcc cgcttcccag ctttcgatct 1944901 caaatgagaa gttctcgtcc tcatttatac gaacatcgat agcttcaggt tctctgacag 1944961 aaaacgaaga aaagcgcgta tagcccggta tctcggtatg tctgttttca ttaatgaaca 1945021 tatccaacaa atgcgtcaga tcactgatga aatgctgcga aagccttctt aactgcttta 1945081 atgtcggata aggaagctgc cgcagctttt caaggatttc caaaaaaata agccctgtca 1945141 cttcagcatc gctgtcagcc cggtgcggct gatcatgccg cagctgaagc tcctcgctta 1945201 attccgtcag cttataccct tcaaatcccg gaaaaacaat gcgtgagagc tcgacagtat 1945261 caagcacttc acaatctggg agctgaaagc ccgccttatg tagctcatac ttgacaaatc 1945321 caaggtcaaa atggatattg tgggcgacaa aataagcgcc gtcaagcaat tggaatactt 1945381 cttcagcaac tgcttcaaat ggctgttcat tctcgaccat ttgattagag attccagtaa 1945441 gctgctcaat aaaagcaggg attgatttat ttggattaat gtattttgaa aaccgctcag 1945501 taatttgtcc attttcgatt acaaccgctg cgatttgtat gattttatcg cctttcttcg 1945561 gcgaattccc tgttgtctct acatctataa caacgaaccg ttgcttattc attaaaatgg 1945621 acacctcaat tcttgcatac gacaaaagtg taacacgttt tgtacggaaa tggagcggca 1945681 aaaccgtttt actctcaaaa tcttaaaaga aaacccccga taaagggggc ttttcttcta 1945741 caaaattgta cgggctggtt cgttccccag catttgttca attttgtttt gatcattcag 1945801 aacagccact ttcggctcat ggcttgccgc ttcttgatca gacatcattt tgtaggaaat 1945861 aataatgacc ttatctcctt cctgcacaag gcgtgcggct gcaccgttta agcatatgac 1945921 gccgcttccc cgtttaccag gaataatata cgtttcaaga cgtgctccat tattattatt 1945981 cacaatttgt actttttcat taggaagcat tcccacagca tcaatgagat cttcatcaat 1946041 tgtaatgctt cccacatagt tcaggtttgc ttccgtaaca gttgccctgt gaagtttgcc 1946101 gctcatcatt gttcgataca tattatattc tctccatttc tcgaatatca ataatgatat 1946161 tatctattaa acgcgctttt gaaaaagcaa ctgcaacagc gagaatcatc tttccagcaa 1946221 tttcattcac aggctcgagt tccggatagg aataaagctc tacatagtct atggttccgc 1946281 tagtcgtttc aatgatatct tttgcagctt ttatcaccgc ttcaggatct ctttcaccgg 1946341 cttggacaag ttccgcactt gtttgaaggg cccgatacag cttaggcgct tcttttcttt 1946401 cctcagctgt taagtataca ttgcgagagc ttttggctaa gccgtcttcc tctctgaccg 1946461 tatcgacagg aaccaattca atatccatga agaagtcgct gattaaccca tcaacaacag 1946521 ctacctgctg cgcatctttt aaaccgaaat aggcacgagt cggcttgact agattgaaaa 1946581 gcttcgtcag tacgatcgcg accccgtcaa aatgtccttc tcttgagcgc ccgcataaca 1946641 cgtctgtgcg tctttctaca tgaatcgtga cattcttttc accgggatac atatcatgag 1946701 catctggcgt aaaaagaata tcgactccgg cgttttctgc aagagctgca tcccgctcaa 1946761 tatcgcgcgg atatgcttca aaatcttcat tagggccgaa ttgtgcagga ttcacaaaaa 1946821 tactcataat aacggcgtcg ttttcttgtc ttgctttgtc tgctaaggtt aaatgcccct 1946881 catgcagaaa ccccatcgtc ggaacaaatc cgattgactt gccctctgaa tggtattgtt 1946941 ttatggcttc tttcagctgt gaaatatcag taatctgtct catcttattt tcccccgtac 1947001 aagccgtcaa gcactgtctg gttcatttga aaggaatgct tttgttcagg gaaagcacga 1947061 tgtcttacat cctgaacata tccgctgatt gctgtttcga tggtttcatc aatgcgcgta 1947121 tattgcttta caaatttagg tgttctctca acaccgtggc cgataatatc atgataaacg 1947181 agaacttgtc cgtccgcttt cacaccagcc ccgattccaa tgaccggtat gcttagcgtc 1947241 tcggcaattt tggctgtgag ttctgccggc acacattcca gcacaagcat catagctcct 1947301 gcttcttcgc attttatact gtcttctatt aattttttgg cgctttgttc gtctttgccc 1947361 tgtactttat agccgcccag tacgccgact gactgcggtg tcaaacctaa gtgactgact 1947421 actggaatgc ctccaagcgt caatgcgcga atggattcaa acacgccttc tccgccctca 1947481 agcttcagtg cgtcagctcc gctttcctga acgatagccg ctgcattttt cagcgtatct 1947541 tccttagaca ggtgataaga cataaacggc atatctgtca caataaaggt attcggcgca 1947601 ccccttttaa cggcttttgt atgatggatc atgtccgcaa ctgtcacacc gacagttgaa 1947661 tcaaggccga ggacgaccat tccaagtgaa tcaccgacta aaatcatgtc aactcccgct 1947721 tgttcagcaa gtttagctgc cggataatca taagcggtca gcatgacaat cggttcttca 1947781 gactccttca tttttagaaa atccagtttt gttttcatgt tttctcctcc tcatgtttag 1947841 aggagatgat ctgccgtttt cttctgcaag ccaaaaaacc ttccgttaca acgagaagga 1947901 ttcttcactt tctaaagttc ggcgagtttc atccctctgt cccagtcctt ttttggatca 1947961 aggcagactg ctgcaatgtc tatctatttt aataataggt gcagttcgca ggcgatactg 1948021 cccaatggaa gtataccaaa atcaacgggc ttgtaccaac acattagccc aattcgatat 1948081 cggcagaata gattttttta atgccttcgt tcgtttctaa aagcagaacg ccttcatcat 1948141 ctatacctaa cgccttaccg taaaaggttc cgtttaacgt tctggctctc atattagtgc 1948201 caataccgag cgcatagctt tcccataaaa gcttaatcgg cgtaaatccg tgcgtcatat 1948261 aatcccggta ccgtttctca aagcatagta aaatatgctg gatgacgccg gcccgatcaa 1948321 ttttttcccc agcagcttgg ctgaggcttg tcgcgatgtc cttcaattca tctggaaaat 1948381 cattaggctg ctggttaacg ttaatgccga tcccaatgat cactgaacgt acgcggtctt 1948441 cttcagcctg catttccgtt aggataccga ctgttttttt tccgttaatc aaaatatcat 1948501 ttggccattt aatatccgtt tggatgcctg ctgcctcttc tattccctgc acaacagcta 1948561 ctgcagcaag cagagtcagc tgcggtgttt tttggagcgg aatgtcaggc cgcaaaatca 1948621 ggctcatcca aacaccgttt ccttcttgag aatgccatac cctagacatt cggccccttc 1948681 cggctgtttg tttgtcagcc accacaaggg tgccttccgg tgcgttatta ttcgcgagct 1948741 catgagccgt tttttgcgtg cttgaaagaa cgtcatggta aataagatgc tggcccatca 1948801 cttccgtttt taatccaaaa cgaatttcgc tttcactgag ttttccgggt tttttgatga 1948861 gccgatatcc ttttcttcta acggcttcta cttcataacc ctctttccga agctcttcaa 1948921 tatgcttcca cacagcagtt cttgaacagc cgagagcatc actgattttt tggccggaaa 1948981 taaattcatt gccggcctga gaaaataatt caataaggtc ttttcttaat gttgaccgca 1949041 tgtcttcagc cactcctcta tgtgtttctt ttgattggag agcttccctg tcacaacagc 1949101 ctgctcgatc cactgtaatt cttctgacac ccattttccg gccggccggt ttcgaagcgc 1949161 aagcaagtcc ttacccgtga tatcaagatc cttaaggctt ttgatcggca ggttttgata 1949221 agcgtactga atgtccttca gtttcttttc atccagtttt tcgttttgcc gaagctgcga 1949281 tattttggcc gctgagagca gtgctttttt cccagctctg tacattgtca ttgcgtcaag 1949341 gctctggcca aacgtatcgg caatgtgaat ggcttccttg atcacttttc ccgggagctt 1949401 ccaggctttc aggaaaaggg gcgcgtcttt caaaactatg ccaaggttaa ttaaaagagc 1949461 agcccaaagc tcctcacggg atgttaaaga gaagaatgga aactcactcg ttgaaatcag 1949521 gttttctcgt ttatgataaa aaccaggaag ctcttcatac aatctcgttt gaatgagtgt 1949581 ttgaagcgcc tggcgagaag ctcttccctg cagcaatttc tcaaactcta tagtttttcg 1949641 ttcgactgaa acatgggaga ggagtgattt ttctttcgca atggcttctt ctgtttccgg 1949701 tgaaagcgta aagccaagct ggctcataaa gcgtacggct ctcagcatac gaagcgcatc 1949761 ctcttgaaat ctatcctcag gctttccaac ggttcgaatc actttctgat caatatcttt 1949821 cttgccgcca aaataatcaa gcaccttccc gtccgctgtc atggccatcg cattgatcgt 1949881 taaatctctg cgttttagat cctcttctaa tgatgagata aattgcactt ctgacggtct 1949941 tctgaaatca acataatcag attcagtccg gaatgtcgtg acttcatagg tttcatcctc 1950001 ccagagcaca ataatggtcc cgtgctcttt gcctacatca acagtccgct gaaacagccg 1950061 ttctacttga tcaggtgccg catctgtcgc gatatcgaca tctccgatcg ttcgtttcat 1950121 atagctgtca cgaactgcgc ccccgacaaa ataagcctga tggcccgctt cgattaagat 1950181 gcggagcacg ggaagtgctt tgataaaaac tttttccatg tgatcactcc ggttctgcta 1950241 aatcggcata aatctgttca tactggctga caattttttt agaagaaaat tcattttcaa 1950301 gcatctctat tgccgccttt gtaaaacgat tgcttagctg ttcatcttct aaaatgctca 1950361 tcgcgcgggc tgttgcggcc gtaacatcac cgacatccac caaaaatccg ctcacattgt 1950421 tttttataac ctcagggata ccgccaatgt ttgttccaat acaaggcact ccgcaagcca 1950481 tcgcttcaag caggacaagg ccaaagcttt ctttttcaga tagcagcagc ttcaaatcgc 1950541 taatagaata aagatcttca acacggtctt gatttccaag cattaagact tggtcttcca 1950601 agccatattt tctgataagc tcgcaggctg tcgatttctc cggaccgtct ccgactaaaa 1950661 gcagcttcgc tttcgttttg ccagcgatat tgcggaacac acggatgaca tcctgcacgc 1950721 gtttaacttt tctgaagttg gacacatgga tgacgacttt ttcatctggt aaaattccat 1950781 gtttctcttt aattgccgct gtgtttttct tcagatacac gcgctcgtct ataaagttat 1950841 aaatcgtttc aatttttttc tccggtttaa ttaaatcgta tgtttcagcc gcaagcgctg 1950901 aggagacggc cgtcaccctg tctgatgact caatagcaaa acggatcaga tcttttagag 1950961 acggatcata acctaacacc gtgatatccg tgccatgcaa agtggtaaca atgccgatat 1951021 tgcgtttcag catttgtttt gcaagatagg cgcaaacggc atgcgggaga gcatagtgag 1951081 catggataat gtctaaattc tcccgttccg ccacctcagc gattttgctt gccaatgtca 1951141 aatcatacgg aggatactta aaaacagcat attgattaac ctcaacttca tgaaaatgaa 1951201 tattgggatg atatgtattc agtctaaacg gaatgcttga tgtgatgaaa tggatttcat 1951261 gtcccttttc agcaagctgc ttccccagtt ctgtcgcaat gatacctgag cctccaacgc 1951321 tcggatagca tgtgattcct atttttagtt ttctcattgt tcgcccccaa gcacatcatg 1951381 atcaagcatc agcatccgtt tggaaaagaa accttcggca tactccacgc ccgcttcttt 1951441 accgtaaagc ttttctctcg cttcaacgat ttcaatatac ccattcgtca gaggagtaga 1951501 aacggaatcc tttgacggga taaactggct tttgtaggcg ttgaggcttt gtttctttgc 1951561 ctctattgta tccgagatat caataacaaa atccggctga tgaaaaccat ttatcatata 1951621 atagtaaacc ttgctgactt tatgcgccgg aaggcttttt tcgtctttat atttatggat 1951681 tccggcggaa aagatcgctt cttccaccag tgcagccgca ttgccgtgat ccggatggcg 1951741 atccttttta tacggcataa aaaccgcttt tggccgacag attctgatga cagtgacaat 1951801 tgaccgaatt gcctgatcac tcattattag gccgcggtct ggaagcgtta gctgaattct 1951861 tttatctgcg cctaatatgc gggctgcttc agctgcttct tctttacgca aactgaccgt 1951921 accgttagaa gagagttccg cttctgtcaa atcgcatatc attacttttt tttcctgttt 1951981 gacaaacttc gctattgtgc cgcccattcc gatctcgaca tcatcactgt gggcgccaaa 1952041 agcaagaacg tcagcattat acattcggct cttctccccg aagaaggtca cggaattcga 1952101 aaacaccttc atcaagtgtg cgcacaagaa tttccgcagt acccatattt gtggcgagcg 1952161 gaatggaata cacatcacat aaacggatta atgccgagac atccggttca tgcggctgcg 1952221 cggtcagcgg gtcgcgcaaa aaaatgacaa gatcgagtgc attggcagcg atcagtgcac 1952281 cgatttgctg gtctccccct aaagggccgg attgaaaacg ttcaatttga agacctgtcg 1952341 cctcatgaat tttcaaccct gtggttccgg ttgcgtatag atcatgattc tttaaaatat 1952401 cccgataggc agtcgtaaat tgaaccatat cctgtttttt cttgtcatgc gcgatcaaag 1952461 caattttcat tgtttatccc cccgtctaat caatgatatt ttctaaacca tacacaagct 1952521 gatcaatctt catgacttgt tcgactgaca gtttaacgcc tgacatgaaa gaagcacggt 1952581 tataagaatc atggcgtatc tgaagcgttt ggccatccat gccgaacatg acctcctgat 1952641 gcgcgatcag tcccggaaga cggacgctgt gcaagcgaat accgttttgc tccgctcctc 1952701 ttgctcctgg gagaatttct ttttcatccg gatgtccttg ctgcttttct ttacggactt 1952761 ctgaaatcat ttccgctgtt ttaagcgcag ttccgcttgg tgcgtcaagc ttctggtcat 1952821 gatgaagctc aataatctca acatcctcaa aatagttggc agccattttt gaaaatttca 1952881 tcatcagtat cgcaccgagc gcaaaatttg gcgcgatgat ggctccgatc cctttttctt 1952941 ctgttaaaga tgtgagctct tttaaatcag cttctgagaa accggttgtt ccgacaactg 1953001 gacggactcc gtgctctaat gcaatttttg tatgtacttt tccgatttcg ggcgttgtta 1953061 aatcaatcaa gacatccggt tgtgtttctg taaaacaggc atggatatct gtgtaaatga 1953121 aagcatctga ctcaacaggc atcacatcag ataatttttg ctgatcgtat gtatggtcta 1953181 tggcccctac aaggtcaaaa tgtggtgttc gttctgccaa tttaacagct tcctgcccca 1953241 ttcttccacg cggtcccgca atgactaatt taattgtttc gtttgacatc ttgatctcct 1953301 ctactttcct tcttcttttc tggtccagcg atctttatct cttgtattaa atttatgcat 1953361 gactcggtcg tgagcttcct ctaaagagat atcaagagag ttggctaaac aaaccaatac 1953421 aaatagcaca tcgcctattt cctcttccat gcttttatca tcttcagtcg ctttttttgg 1953481 tttttctcca taacggtgat tcacttctct ggcaagctcg cccagttctt cagtcagcct 1953541 cgccatcatg gccagcgggc taaaatatcc ttctttaaat tggcctatgt aacggtctac 1953601 ttcagcctgt atgtctttca ttgttttatc actcactgaa cgaaacctcc tatcatcctc 1953661 ttacatgtta gctaattcag atacgtttga caaatgttta agcacgtttg ctgttttctt 1953721 tttcatccac tataatataa acgctatcta atggaaggaa aaggggtttt gtgtgatgct 1953781 tggagaaatt agattaaaaa acatattttt tattttaatc ggagcggcaa ttttttcatt 1953841 tggcttggtt catttcaata tgcagaacaa tctggctgag ggcggtttta caggtattac 1953901 acttttgctt tatgcccttt tccacatcag cccctctata tcgaacctgg tgttgaacat 1953961 tccgattttt tttattggct ggcgtttgct cggcaggaca atgtttgttt atacccttgt 1954021 cggcactgta gccttgtctt tgttcctcag catctttcag cgatatgaaa tccatatgcc 1954081 ccttcagcac gacttagcgc tcgccgcttt atttgccggc gtattcatcg gagccggact 1954141 gggtattatt tttaagttcg gcggtacgac aggcggtgtt gatatcatcg cacgtttagt 1954201 gaataagtat tttgggattc cgatgggcag aacgatgttt gctttcgatg cctgcgtcat 1954261 cattttgtct ttgcttactt atctctccta taaagaagcg atgtatacgc tggtagctgt 1954321 atttgtagcg gcaagattaa tcgattttat tcaggaaggc ggatacgctg ctaaaggcgc 1954381 tacgatcatc tcttcgaaaa acgacctgat tcagaaaaag attcttgaag aaatggaacg 1954441 gggcgtcacc attttgaaag gacaaggttc ctacacaaaa gaggatatag atgtacttta 1954501 ttgtgtggtg ccgaaaaatg aattggtgat gctgaaaagc gtgattaact ccattgatcc 1954561 ccatgccttt gtagcggtaa gcgatgttca cgatgtgctc ggagaaggat ttacgcttga 1954621 tgaaaataaa aatccgcttc cgcgctgaca tgtaatagaa aaaaggcggc tgaccgccgc 1954681 ccctcatcct tatttagggt agtccctttt tttcagcttg tttttttccg ccttgtactt 1954741 tctgtaaccg acataggtaa gagcagtaat gatgatactg ccggttgtaa tgatcaccca 1954801 gagtaaagac ggatcggcat catcctcctc caccctgtca aacacatttt tcaggtcatg 1954861 ctgaagaagg gaaagccgtt caagcttcgt gctctctgtc atttgctgaa attcctcttg 1954921 ctcaataaca tctatatgtt ttccgactgt ttcaagctga tcctctgata catcgattgt 1954981 aagactgggg taaatcaagt catataaact gataaattca ttccattttt catgaaagct 1955041 tgtgcttcca ttcttttgga catctcgctt cagttcagta aaagcttcca taatcggttt 1955101 ttccagtgag ccccaaagcg ggtcagaccg attgtcaacc gcatccatca gcattctgaa 1955161 ctgcgcggct gctctgagtt tttgtgtgtc tgatgtatca gcttgcttta aactccgaac 1955221 catatcatta tagcccaatg tgatttgacg aatttgggct cccgttagca tggggtcttg 1955281 ctgttttttc tcagcggatt ttaatgtttt ttcaaaatac tccaagactt gaagcgcctc 1955341 ttcatatttc gcctgtcggg tcatttgaaa gactgtatcg gataaatcat tcaattcctc 1955401 gaggcttccc cgctctgcag ccttggcatt tccattataa aaaataagtg caatcaacaa 1955461 acagatcgtc agctttcgtt tcatgcaggt ccctcccact ctctctcctt acagaatatg 1955521 aagaaaggga caaggataga ccaacattgt ctttacatca gctcaagctt cgtttgcttt 1955581 tttgagacca caagaaagta agcaagcgcg attgaaaaga tacttagcca aaatgttccg 1955641 tatcctattt cagtcatata atcagaaagc atagagtatt gcggcatcat atcaaacaag 1955701 tagtcaatga catcgttatg cagtgtccag actgcagcaa ttgcaagatg ccaaaatgaa 1955761 aaacgaaaat acggactgta taatacgcct tgaactgcca ttgcaaaatg cgaagcaatt 1955821 agcatgtagc cctcccacgg caagtcacca gttactgcaa gcacaagaaa attcatagcc 1955881 accgcccata ggccatactt tacgagggta actagcgcaa gcgcctctaa aagcggagca 1955941 ttccgtttca tgagaaaggc aagcagcaca aacagaaaga aaaacgttgc tgtcggactg 1956001 tccggaacaa aaatcaggaa acgggccggt gtctccaaaa gctgcggcaa gtaccaatag 1956061 tagccgtaaa ccgttcccag aaaattaatg gctaagacaa gaataagcat cggccgctgc 1956121 cctaatacat attgaaacca tttcacatcg aatcaactct cagtctgtaa aaataatatg 1956181 tccatataaa aaagctgacg ccgggtcagc ttttgataat aaaagtatat ccttccattt 1956241 gacaattcac aatacgttat tttgcggttg tttcagaaat aaattttgca agttcttcga 1956301 gctgcttatc atttcctttg aacacacccg ccggcatttt gcctttccct tctacagcga 1956361 tttttttgat ttcatccggt ttcagcccgc tgtcaaccaa tgaaggcccg gccgctcctc 1956421 cctgaaggtt atccccatgg caagaaatac agccctgttc cttaaaaacc ttatatcctt 1956481 ctgcattggt gtcaatgtcg gcttcttttg taattttccc ctgttcttct gccttggccc 1956541 agtcatgagt agcaactgac tgccacgtca aaaatacagc agcggaaatg gccagaagca 1956601 tcataccgac agcgaccgga cgcttccacg gccttctttc tgtccctctg tctaggaatg 1956661 gagccaaaag cagggcccca aaagcgagac ctggcataat catggcgccg accactgtaa 1956721 agcttccggc ggcgtattca tacttcaaca gctggtataa gaaaagaaaa taccaatccg 1956781 gcagcggaat ataaccagta tcagtcgggt ccgccatccg ctctaaaggc ggctgatgca 1956841 caatcgtcaa aacgagaaaa ccgatgagaa agacagctcc aaccatccat tcctttaaca 1956901 agaaatttgg ccagaaagcc tctgttttac ccggatactc cgaataatcc ttcggtatat 1956961 tcggcttttt ttcagccggt atccttgagt cgcctacaaa tttcatccct ttgccccggt 1957021 gcatgtcatc ccctcccttt tattcgcaga tcaagagttt aaagcggtcc tgaaatcccc 1957081 tgcttccgga tcataataaa atgtgcagcc atcagcccga acaatgcggc aggaagaaaa 1957141 aatacatgga tcgcaaaaaa cctagtcagc gtttgggcgc ctacaatatc cggatgccct 1957201 gcaaggagcg ttttaacttg cgttccgatc aaaggcgtgg cttcggcgat ctgcagtccg 1957261 acttttgttg caaacagagc cttcatatcc caaggaagca agtagcctgt aaagccaaga 1957321 ccgagcataa caaaaaagat cagcacaccg acaatccagt tcagctcgcg cggtttttta 1957381 tacgcgcctt ggaaaaagac cctcagcgta tgtaaaaaca tcatcacaat gaccaggctc 1957441 gcaccccagt ggtgcatccc cctgacaatc tggccgaatg ccacttcatt ttgcaaataa 1957501 tataccgatt cccaggcatt tttgatatca ggcacataat acatcgttaa aaacattcca 1957561 gataatactt ggataacggt tacaaaaaac gtcagtcccc caaagcaata cacaaacgca 1957621 gagaaatgat gggcgggatt cacatgttcc ggtacttcgt gatcggcaat atccctccac 1957681 atcggtgtaa tatcaagccg ctcgtctacc cagtcataaa ttttgttcag catgtcaccc 1957741 ttccccctta ggctttgctt ttccaagata caggaagccg tcttttactt cttgctcata 1957801 atgatcaaga ggcgcaagcg gcggcgtgcc agggacattg gtgccgtcct tttcatagag 1957861 tccgtaatgg catggacaaa agaatttatt cgggttttta ggatcactat tccagttcac 1957921 cgtacaccct aaatgcttac aaattggcga aagtgctaca atttcatccc cgtttttgaa 1957981 gacccaggct gatcttgact cttctgactc ataccaggca tcgacttgat taattttaaa 1958041 atcaaagcgc tgcggctctt ttgtcaactc atcaacgctg acaacctgaa ccatatcctg 1958101 cttccctgtc gattttaata ccgggtcgag tgcgaagcga accataggca tgagcatact 1958161 agccgccata aaacctccta cgcctgtgag cgtataattc aaaaattgac gtctggatat 1958221 atcatgtttt ccgcccatct cttctccccc ctctaagtca cccctgcaaa ctgactaaaa 1958281 tagaaaatat tgcaataact ctagacaccc tcataatata tgaatctctc agcaaggtca 1958341 atatagccaa aatattgttt ataaggaaat gtaagtgttt ttataaagtg ctccataact 1958401 gtaacaaaac gttcaaaatt tcagcagtgc gttcatccaa tatttttctt tttaaagagt 1958461 catttaaatg ctctaatgga acagacgatg taacaatcat tttgcctaac gcatcctcag 1958521 ctctccaact ttcgtcagat gtgagcagga caacatgcgg aaattccgtt atcagctctt 1958581 cccgcaaatc cttaagccct tgaacggtta tttcatttct atcaacatat gtataaggcg 1958641 gaagtaaata tacccgtccc tttaactgcc tttcaagttc ttctgagaga agctgcgtaa 1958701 actcgccttt ctccgccgcc attttaaaat ggttattaac ccttatgtta attaatggta 1958761 tgacagcggt atcaatgtaa tccttagctt gtaaatagtc cttggcatca gtgattctcc 1958821 acctcatcgt tctccccctt tacggcaaca agccttgcaa ttcactgcaa ggctggtcat 1958881 attatgtgag ctgatttaat tggcgcgata attgttcaaa tgcctcttta tcatgacgat 1958941 ctaacgcgtc gtcaatgtct tttaataatt tttctctttg gaatgtggaa atagcgtgct 1959001 ctaaaatctg ttccgccaat ccctgatctt ttttattctc aaaaaggttt ttcggaatat 1959061 gcgggttgga ctccagcacc gccgcatatt caggtgagct gtaagccgaa cggaaattaa 1959121 gctggataaa caaatcctgc tgtttattta atctaatatc atgaaaagat ttttccgcgt 1959181 cggtagtcat gacattctct ttatagaacc ggaacggaac ttcttcaaca caatgtgttg 1959241 acattataat gcctctcggg caaaattcag cctgctccac aaaatgaacc ttctccatga 1959301 gagaatcatg gctcattaag tagttcaaga tccaaacgca ctctcggcgc tttaactgat 1959361 aatggtttaa aaaccaacgg ataaaatctt ttttctcatt gacagaaaca ggggtctgca 1959421 tgtaattccc tcctctatcg ttcgtataat ctatatactt atatgttcca catgaatggt 1959481 taatattcct gcttatctag aaaattcatc ctcgattcgc aaaatcgttt cttcaagctc 1959541 ttcattggct ccgtccattt caagaacctt tttcaaaagc ggcagcgctt ctttttgaag 1959601 accttcttct aataggaagc ttgcgtattc atataagaaa tctctatcct cccggtaatg 1959661 aagataggca gcctcaaagg attgttttgc ttcctcgtat tgctctaatt cagtatatgc 1959721 gcttgcaaga taccaattgt atttaggatc ttcttcaccg tagcttcgaa cctcttgaat 1959781 aagatcaatg atctgatcat aatcctcttc tttgtgatac acggcaagaa gtgtatgaag 1959841 cgcctcgaca aagcccggat caagcgcaag cgcctcctga agcagcttct tcccctcttc 1959901 tgacttcccg attttcaagg ccattttggc ggcataaagg aaaagttctt tgttatattc 1959961 atcatatctg atcccctctt ttgccgtttt taatgcctct tcatacattc cttcagcttc 1960021 atagcttttc gagagcggca tataaagtga agtataagat ggatcaagct cctttaaatc 1960081 agacagctgc ttaatagctg ttttcacaag ccccgcctgt aaggctgtaa aaccatagcc 1960141 gaaaatcgta ttaggatcag gattctcatc gacagctttc tcataccatg gaatggcatc 1960201 ctcaaattca cctgaggcac ttaacgattc tgccagtctt tgatggacat taacgccccc 1960261 gatctcactc tgctcctcag ccgttgtttt aaaatattga accgcttttg cataggctcc 1960321 ctgagcaaag taaagttctc ccagtgcaaa atcaataaca ggttcattgt ccagaatgga 1960381 ctttgcctgg aaaagctttt gttcactgac ttcgaataac ccctgcatct gataaagatc 1960441 cgccataagc agcaaacttt ccggatatga tggatctgtt tccggaatag tctccagcac 1960501 agcgagggct ttttcttctt cgtcaatatc tattaaaagt tcagcgtaga aattcgtcag 1960561 ttctgtttca tttggatata aatcatgtag atcactaatc agtgaaatgg ctttttctac 1960621 atcgccccac tcgtaataaa gctgggctgc aatggcttta tcttcatcat gcagctgttt 1960681 ttcagccttc gagagcgtgt tgaggccttt ttctgtttca cctgcttcaa ctaattttat 1960741 ggcttcttga atcaatgtat tcaaatcgga ccggtccttt cttttcctat acaacatcaa 1960801 ccatacaaaa aaagctttat ttgttcgggt taatcttatc ataattcaga cgaatgcccc 1960861 cggcaaataa gatgcttctg tacggaaggg aattattgag tcttattagt ttaccaaaag 1960921 atcttgagat agaaaatgaa aaaaggaaga tcgccctctg tacagtaaag cagctctttg 1960981 acctgccggc ttgtaagtaa agcacatccc cccttttcgt ttttctatcc gttctataag 1961041 acaagctatg ttttttcgcc tcgaattatg atctgcataa aaaatcctga agtaaaactt 1961101 caggattttt tcgaaagctt atttaaatgc tcgaagaagg ttggataaga aacgtgaatg 1961161 gcatccgtgt gctcgatttc aatcggctcc tccgttatac aggaagcaat accaagcatc 1961221 attccgattc gatgatctcc gtggctggac actgcagcgc cgcctttcaa cgtttgtttg 1961281 ccataaacct tcattccatc tgctgtcggt tcaatttcag cacccagctt gcgaagctca 1961341 gaaacaacag tatcaatacg gtttgtttct ttcactttta gctctgccgc gtccttaata 1961401 acggtggttc cttccgcctg agtcgcaaga agcgcgatga tagggatctc atcaattaaa 1961461 cgcggaatga tatctcctcc gatttcaact gcctttagag atgacgtttc tataatcaaa 1961521 tctccataag gctctgcacc gctatcagca gatggtttga tttcaagttt tgcccccatg 1961581 ttttgaagga catcaataat acctgtccga gtcggattta aacctacgtt tttcaataca 1961641 attctgctgt ttggaaccat cgcgccagca gcaaggaaaa acgcggctga agaaatgtct 1961701 ccaggaacaa aaatatcagc agctgtcagt ttctggccac cagcaatgga aacactcgtt 1961761 tgatcttcag aaagcttaac gccaaaagca gaaagcatcc gctcagtgtg gtcccgagat 1961821 ttatggggct ctgttacagt tgttgtgccc tcagcctgta atccggccag caaaacagca 1961881 gatttaattt gcgcgcttgc aacaggtgat acataatcaa ttccttttaa tgaagcgccg 1961941 ctcactgaca gcggtgtaaa ctctccgccg gctctgccgt cgattttagc ccccattttt 1962001 ttcaaaggct cagtcacacg cttcattggg cgtttcgcaa tgctctcatc tccggctacc 1962061 gcgctgtaaa aaggacggcc cgccaatatt ccgagcatca ggcgaatcgt tgtacctgaa 1962121 tttccgacat ctaaaaggct ttctggctct ttcagggcat cgattccttt tccgtgaatc 1962181 acgacatcgc tgctgctttg ctcaatgtga acacccattt ttctaaagca atcgatcgtg 1962241 ctcagacaat ctgctcccgg cagaaagttt ttaactgttg ttgtgcctgc cgctagcgcg 1962301 ccaaacataa cagagcggtg agaaatggat ttatcaccgg gaatatgtat ttctccatgt 1962361 aaggtctgca ccttatctcg tttcattttt tccacctcaa tcagcataaa aagtttcata 1962421 ttccgcccgg gcttcaatgc attgttctgc ccttttgcgg tcgtcatcag actgaaaact 1962481 gatccttaaa atcccgttaa tatcctctcg tgtttcgata atgcggatat tcgtgatact 1962541 gatgcgctcc gcagctaaga tcgctgttat ctcggatatt acacccggat gatcgggtac 1962601 atccacatat aaatcataaa atgcaggtat cgctcccttc tgccgaagcg gcagcccgtc 1962661 gcgataatcc ttggctgttt taaaataacg aaatagattt tccgcatctt cttgttctac 1962721 atatgtacgg atcttgtcaa tttcacgaat ccactcatca aaacggtcta agattttatc 1962781 tttattatgt aataaaatat cccgccacat tgccgggctg cttgatgcaa tccttgtaat 1962841 atctctgaac ccgccggcag caaaacgctt aacaagcgga tacaggtttt ccgaatgatg 1962901 ggtttggtga acaaggctag ctgctacaat atgcggaaaa tgactgatta cgcttgtaac 1962961 gccatcatgc tcctctggcg acatttccac aaaatgggca ttcgtcccct tcagcaggtt 1963021 ttttaactgt tccacagctt gtttgtccgt tttctggcct ggcgttaaaa tataaaatgc 1963081 attttcaaac aggaactcct tcgcagcggc cactcctgat ttatgtgaac ccgccatcgg 1963141 atgccctccg acaaattgat agcggctagg cagcacttga tcagcgtaat caaccacttt 1963201 ttgctttgtg cttcctacat ccgtaatcaa aagctcatgt tcaattcctg aatgagccag 1963261 ctcttcaagc ataaccagtg tttgttcaac aggtgtcgca atgattactg tagctgcctc 1963321 tttcacaccg ctaataaacg aatcagcacg atcgtctatc acgcctaatt ttaatgccgc 1963381 taccgcctgt tcatcagaga tgtcgattcc gataatccgt ttgccgggat gatttttttt 1963441 gatggctagg gcaatcgaac cgcctatcaa tccgagaccg gcgagcaata ttgtatcttt 1963501 catttgattc atacgtcatc acctggttta tagactaaag aggtgatatt tgatcacctc 1963561 ttataaaatt tcagctaaaa tggcaagtat ttcttcattt tgctcttttg ttccgatcgt 1963621 aatccggagt gatgtcggga aacctaatgc gtttcctgac cggacgatat agcctttttc 1963681 cagcagagcc tgaaacagtt catcagcagg acgtttaaag tcaattaaca caaaatttgt 1963741 ctgtgaaggg tagcacttta aaccatgagt tttcgcaaaa tcataatact gctgaaggcc 1963801 tgcattattt tgctcgacac aggaagcaat aaacgcttga tcatcaagtg ctgcaatcgc 1963861 cgcagcctgg cccagacggc tggtattaaa cggctctctc gccggctcaa tctggcgaat 1963921 caggttctcg tcagcaattc cgtatccgac tctgagcgct gccagaccgt atgcctttga 1963981 aaatgtgcgc aaaatcatca aattggaata cttgcttaag agcggcacgg tttccgggta 1964041 atcctctgct gttacatatt cataatatgc ttcgtcaaga acgacaagga cacgagaagg 1964101 aacgcgctcc agaaatgcga gtaattctcc ttcagatgta taagtgccag tcggattatt 1964161 cgggctgcat atccaaacga cttgtgtctg ttcgtcgatg gcttctaaca tggcgtctaa 1964221 atcatgtgag ccgtcgggac gaagtgcaat ttcacgtact tcagcacctt caataaccgc 1964281 attatgttta tattgcggaa aagtgggggc agcagtaacc gtgtttgttt tatcgtttaa 1964341 aaatgcccgg cagatgatct gtatgatttc atcagaaccg ttgccgaaaa taagtgatgt 1964401 ttcgctgaca ttgaggtgct tactgagcct tgtccgcaaa gcggcgctat acccgtccgg 1964461 gtaaagggct agctgttgaa tctcatgatg aagcgcctct tttgcagcct ctgaacagcc 1964521 gtaaggattc tcgtttgaag caagcttcac aactttatcc aagccatatt ctgatttcac 1964581 tgcttcaatc ggctttccag gctgataagg cttcagctgt tttaaatgtt ctttgatacg 1964641 caaatcagtc acctcatttt aaactgtaca agccgctaaa cgccattgca taatcctcaa 1964701 actcctgcag cgcctgattt ctcgtttcag cgctgatgag ccggtccttt aattcttcta 1964761 tttttctgac gagcgcactt cccactacga caccgtcact aatttcattc atctttatga 1964821 cctgttcacg gtttgatata ccgaacccta cagcaaccgg aacagtgctg agattcttca 1964881 cagtacgaat gaacgggtac acggatgaat tgaactcatt gcggacaccg gtcacaccca 1964941 gagaagatac acagtagacg aacccctcgg cttgttcaat aatggttttc aaacggcttt 1965001 cgcttgtcgg cgcaactaaa gaaatatacg tcacctcatg gcttttacat tcctcttgaa 1965061 ggctgttgct ttcttctaat ggcagatccg gaacaagcag accgtcaata tgattttccc 1965121 gcagtaaagc gaaaaagtat tctttgttca attgtaacac aggattataa tacgtaaaga 1965181 ggataatcgg aatattcact ccgttttttt tcatttctcc gcctaattcg attgccttta 1965241 cgatattcat tccttgatca agcgcccgct ttgaagcccg ctggatcacc ggaccgtctg 1965301 caagcgggtc agagtatgca acaccaagct ccaatgctgt ggcgcctgct ttttggagtg 1965361 acttcgccag ttcaatcgaa acctcaggaa ctggatcgcc cgccgtaata aacgggataa 1965421 acaatttttc tgatggttga agatccaatt taaacatggg ctttcacctc ttcttccaat 1965481 acattcatta atgtgttgac atccttgtct ccccggcctg ataaacagac gagaatgagt 1965541 tgaccgcgat ccattccttt ggcgagtttg aatgctttcg ctaacgcatg ggcagattcg 1965601 attgccggca aaatcccctc tttttctgac aaaagcttta atgcatccac cgcttcttca 1965661 tcggttatac tgtcataagt gacacggccg cttttatgca aatatgcatg ctccggaccg 1965721 attccaggat agtcgagacc ggctgaaata gagtagggct caataatttg cccgaactca 1965781 tcctgaatga gataagtcaa tgaaccgtga ataaccccta cggttccttt cgaaatagtg 1965841 gcggcatgaa gaggtgtatc aattcctttt cctgctgctt cagcgccgat cagttcaaca 1965901 tcttcattta aaaatgcctg aaacataccc atcgcattgc ttcctccgcc tacacatgcc 1965961 actactttat caggcatagt gccttcaata cgtttcaact gatccttcgc ttcctctccg 1966021 atcatttttt gaaattcacg gaccacttgc ggataaggat gcgggccgac aactgatcca 1966081 atcatataaa agtgatcctc acaatgctga acccagtacc ggatcgcctc atttgtggca 1966141 tccttcaatg ttccgtttcc gcttgttaca ggcactacct ccgctccaag aagcttcatg 1966201 cggaaaacgt tcagagactg gcgggcaaca tcctcttcac ccataaacac agtacaggaa 1966261 aagccgaatt tggctgcaac tgttgcagcg gcaacaccat gctggccggc accggtttca 1966321 gcaatgattt tcgttttgcc cattttttta gcaagcagcg cttgacctag cgcattattg 1966381 attttatgag aacctgtatg gtttaaatct tctcgtttca aatagatttt cgcgccgcct 1966441 aagtattcag tgactcgatc agcgtatgtt aatgcagtcg ggcgtccgga atagtccttt 1966501 aacagcttat aatactcttc acgaaaagcg ggatcatcct tgatttgttt aaatgctgtt 1966561 tgtatttcat ctaacggctg catgagtgtt tccggaacaa actttccgcc aaaatcaccg 1966621 tatctgccta tttcattcgg atatggatac atatcggttc atcctttctt ctaaaagcct 1966681 catcagattc tgatcttttt gtccgttttt ttcaattccg ctggcaaggt caattccttc 1966741 tggctgccat ttcaataggc gtgtgatgct atccggattc acgccgccag cgataaagca 1966801 gcgtttacca atagccgcct gctgatattc cggcacacat tcccaagaaa atgcaacacc 1966861 agttccgcct ctagaccctt ttacagatga atcaatcaca aagccgtcaa cattatcttt 1966921 aaagcgggct atttcttgag ttgtgttatc ttgatggtga agcgccttcc atatttcaca 1966981 gcctgtcagc ttgcgaagag cagcagcatc cgccggtttt tcatcaccgt gaagctgaat 1967041 gacgtcgagc ttcaagctct tggcaatacg tgacatcgtc tctattgatt cattaacaaa 1967101 aacacctgca acctgttttt cgacacgaac ttggttcagc cattttttca catcttccgg 1967161 agatactttt cgtttgcttt cagcaaaaat aaatcctagg taatcagcct gtgattccgc 1967221 cgcaagctgc aaatccttta gtgaccgaat accgcaatat tttaatgccg gtttcttcac 1967281 aacctcactc cctaaacaaa gcatggattg ctttacgctg agaagtttgt ctcatcaatg 1967341 attcaccgat aagtacagct cgtgctccat gttctttgac aaatgttaaa tgttctaaag 1967401 aaccgattcc gctttcgctg acaagcagtg attctttcgg agcaagagat gcgatttgtt 1967461 ctgtctgcat gatagaggtt tcaaaagttt ttaggtttcg gttgtttatg ccgagaatat 1967521 caggcgtgaa tactttcaat atttgttcta gcgttgttgc atcatgaacc tccactaaca 1967581 cgtccatctc cttttcacct gcttcaagat ataattcatg aaggtgtaag ggatcaagca 1967641 cttcgccgat taacaatatg gcatccgctc cgattcttct tgattcctcc acttgaagag 1967701 aatcaataat aaaatctttt ctgagtacag gtatcgaaac agcgcgcttt acgtctgata 1967761 aatagctgtt ttccccttga aaaaacgggg tgtctgttaa aacggaaagc gcatctgctt 1967821 tcgcagtttc atagtctttt gcaatccgca caggtacaaa attctcttta ataagccctt 1967881 ttgacggcga cgctttcttc acttcagcaa tcaacccgat aaaccgattc aggcttgcca 1967941 gcgcctcttt aaatgaacgt ttttcgaaag gctgctctac cggcagaacc agtgttttca 1968001 cttcttcttt cttttgtttg atgatttttt caagcataga tctcttcctc tttctgcttt 1968061 agtcgttcaa gctgcgcggc agcgcctccg cttgtaatcg tctctaacgc cagctccgtt 1968121 ccttccttca gtgaggcggt aattcccgcc gtgtaaatcg cagcacccgc attaaaagcc 1968181 gtaatagata aagcggaact gctgctttta ttttcaaaaa tattctgaat gagataagcg 1968241 ctctctttcg gagactgcac ctgtaaatct tcaagtctgc catttgtgaa accgaaatct 1968301 tcgggtgaaa cggtatactc ccggcgctct ccgtccttta attcaatcac gtcggtcggt 1968361 gctgtaattg aaagctcatc taaaccgtca cggcttgata caaacataac gtgcttcggc 1968421 tgaaacgtct ccagtgcgct tgccatcagt ccagcttttt caacagaata gaccccaatc 1968481 acctgacgct tcgcctgtaa aggattgctg agcggcccaa gcagattaaa taccgttctg 1968541 aaacctagct cttttctagt acctgctaca tgtttcatag acgaatggta aagcggcgca 1968601 aaaagaaatc ccatgttgtt tgtttcaatg ctgcttttga ccttttcggg agtggtttga 1968661 atagaaacct ctagctcctc taaaacatca gcgcttccgc ttttagaaga gacagagcga 1968721 ttgccatgct tagcgatttt cgcaccagct gccgaggcaa caattgccga ggccgttgag 1968781 atattaaaag tggaaatacc gtctccccct gttccgcatg tatcaacaat atcaggaagt 1968841 ccatcgactg taagagcgtg tgcccgcatt gccttcacaa aacccgcaag ctcttctggc 1968901 gtctcccccc gatgagcaag aattgacaat atccccccca tttcagaagg agtcatttcc 1968961 gctgccatca tcatattcat cagcgtttca gcctcaccgg cagtaagggt ttttccgtca 1969021 acgcacaatt gtagaaatct gttcatcagc tttatcctcc ttgctatgaa acatgtcttc 1969081 tgcaatatga atcgttttca gcagcgcacc ggctttatta cagctttctt cgtattcggc 1969141 ttccggaaca gaatcagcaa caatgccagc acctgcctgt atcgatgcaa caccgttctt 1969201 tacactcatc gtgcgaatcg taatacaaga gtcgatattc ccgtcaaacc caatgtaggc 1969261 aatacaccct ccgtatgtct ctctcggtgt tggctcgagt tcttgcaaaa gctgcatggc 1969321 acggattttg ggtgcgcctg ttaaagtccc cgccgggaaa gcagacatca gtgcatcgac 1969381 aggatgaacc ccttttttca atcggcctgt aaccaccgag ataatgtgca tgacatgtga 1969441 aaaggaaaca atttttgtga actccggcac agaaacagaa ccatactctg ctactctgcc 1969501 gatatcgttt cgggcaagat caacgagcat gtaatgctcc gctttttctt tttcatcctt 1969561 catgagctca accttcagtc tctcatcttc agctttgtct gcaccgcgtt ttctcgtacc 1969621 ggcaatcgga tggatttcta agtgcccgtc ttgaacgtgt attaaccgtt ccggagagct 1969681 gccgactatt tctctgtcta gcagtttcat ataatacata tacggcgaag gattgacgat 1969741 cctaagcact cggtataact caaaagcatc tgcttttatc ggcacctcaa atttttgtga 1969801 taaaacaccc tggaagatat cgcctgcttt tatatagctt ttgatttttt ctacatcagc 1969861 cataaaagcc gatttttcat aattagaaga tactgtctca aagctgggtg tcttgtatga 1969921 atcagcagaa agaaacagct cttttatgtt tttttggtcc atcatttttt caatgagatt 1969981 ttgaagctcc agatgatttt gatggaatac atccattttt tcgttttttg tttcctctcc 1970041 agtgagcctt gcatattgga taaagtggac gtttttggtt tcatgatcat acgcaattaa 1970101 tgtccggcaa acaaacagca tacacttttc catgtctgtt tctttggtat gcgaaggaac 1970161 agaaggctca atcagcggga tcatatcata gcttaagtac ccgacagctc cgccgacaaa 1970221 aggaatgcca agctcaggtg ttttgatttt gtatgtggta ttcatccagt tcagcacttc 1970281 ttttagttca tttcctgtgt aaagagattt gctgtcctga tcagcggccg aaaaacggcc 1970341 ctgctcttct ttaattgtga gaaatggatt caggccgata aacgaatatc tggaccaagt 1970401 ggatgtatcg tccttgcttt caagaagata cgtaatctcc ctgtcaagct tctctatcat 1970461 ttgaatgggt gtcagtgtat cgactgtgaa ggtctccaca atcggtatcg tgtggtggga 1970521 caagctgtcc tctaaaaatg cggaaatgtt tgattggaaa ttcattgctc tcactcctta 1970581 tggcaaggag aatgagaaga tggcatgaga ggataaaata ctatataaca aataaaccca 1970641 aaagaaagac ttcttttggg tagaataaac ataatgtctc agctcaacta aactcattct 1970701 ctgctaccct attctctaac tcaactcatt ctaattgctt tatacacact cttgtgtatt 1970761 tctaagctgt tcttatcgta ttacaattca gtattttttg tcaatgataa atcgggcctc 1970821 aatacgacaa ctttttctaa atatacatgt ctgatctgat cctgagggac atctgtctgg 1970881 accgtcatca tgactcttat gcactttttc agaccgcctg ttacgtccat ttcctgcata 1970941 catgttaccg gtacatactg ccatcctgaa agctcgcgaa cagcttttgc cgggaaaaca 1971001 gcgtgcaaat caggtgtagc cgacagaagc atttgaacaa catcttccgg ttttgtatga 1971061 ttttcttcta tgattttctc taacagctgt ttagtttttt gtaaaatttc ttcttcagta 1971121 tcccgttcaa ctgtagttgc tccgcgaatt ccgcgaatca tcatgatgtc tcctccaatc 1971181 gccatttgtt cagccagctc tcaagttcat ttctggaaaa tgtatgatca gcaactttcc 1971241 ctaattcgtt gagcacaata aactgaatct tcccgccacg ggttttctta tcattcatca 1971301 tacggttcaa gagaaccgaa gtttccgtct cttttctgat ttgacttgga taacccaggc 1971361 tttttagcca gctgaccaaa cgttttctgt ccatttcaca gcctacagtc ttttcgctta 1971421 tatataaagc aaactgcatt ccgagggcta cggcatcacc gtgagtgatc tgcccatatc 1971481 catattccgc ctcaacggca tggccgagcg tatgcccaaa gtttaagtaa gctcttatcc 1971541 cctcttcttt ttcatcctgc tgaacgacag acgctttaat tgaaatgcct ttaaaaatca 1971601 tgtcattcag ctgatcatta gtgatatcac gcagtgagtg gatattcagc agctcctcca 1971661 gaaacgctct gtcatagata aaagcgtgtt taatcacttc tgccattccg gacctaagct 1971721 ctttttcagg cagagaacgc aggaaatctg tatcatagag cacggctttc ggctgataaa 1971781 acgcaccgat tagatttttt ccaagcggat ggttcacggc tacttttcct ccgactgcgc 1971841 tgtcatgcgc caagagcgtc gtaggcattt ggatgaaatc aatgccgcgc ataaaagtgg 1971901 cagccacaaa accggcaaga tcccctacaa caccgccacc gaatgcgatg atgcatgagg 1971961 agcgatccat atgaaaacga atcgcttcac tctgcaattt tgtgtacatg tccatggatt 1972021 ttgcctgctc tccactcggt accgtcactt ttttcacagg ccatttttct tgcagcaaat 1972081 ggagcatttc atcaccatac aggcggtcca cttcttcatc cgtgacaaac ataatccttg 1972141 ttaaaggcct gtttaaagag gttaatagtt cgcaagcctt ttttctgata ccttgtccga 1972201 taaaaacagg atatgacgag gaagcagttt gaacatgcag tgtcttcatt aaaattccct 1972261 cgacagtttt ctcatattct ccacattttc tctaatgcgg tcaatttgat ctaatccgaa 1972321 ttgttcaacg actgcgttcg caatttccca agcgacagcc gcttcagcga ctacacttgc 1972381 cgcaggaaca gcacagctgt ctgaacgttc aatgctggca gaaaacggtt ctttcgtttc 1972441 aatatcgaca cttttcagcg gtttatacaa agtcggaatc ggcttcatga ctccgcggac 1972501 aacaatcggc atccctgtcg tcatgccgcc ttccagtccg ccaagtctgt tagtagcacg 1972561 ggtgtatcct ttttcctcgt cccaaatgat ctcgtcatgg acttcgcttc catttcgccc 1972621 tgctgcctca aatccgatgc cgaattccac acctttaaat gcgttaattg acagaacagc 1972681 ggcagcaagc ttgctatcca gcttgcggtc ataatggaca tagctgccca cgcctaccgg 1972741 cattccctcg acaatgactt ctactattcc gccgatggaa tctccgtttg cctttgcttc 1972801 atcaatggca gccatcattt ttttgcctgc ctcttcatcg tagcatctga caggagactc 1972861 ttccgttaca cgctgcaagt cttcaattga cgtatactct gttttttcag ctttaacagc 1972921 gccaatttgc aacacgtggc ccgccacctt aatgccaagc tcagaaagaa tctttttagc 1972981 tacagcccct gccgccactc tgacagttgt ttcccttgct gaagaacgct caagcacatt 1973041 tctcatatca cgatgattat atttaattgc accgtttaag tcagcgtgcc caggtctcgg 1973101 tctggaaatc tggcgcttca tttccttttc ttcatcttct gtaatcggag cggcgcccat 1973161 gatttttgtc caatgcttcc aatcgttatt ttcaactacg agagcaattg gcgaaccgag 1973221 tgtacgtgca tggcgcaccc cgctcataat tttggcctgg tctttttcga tctgcatgcg 1973281 gcggccgcgg ccgtgtcctt tttggcgtct ggcaagctca aaattgatat cttcctccgt 1973341 tatgtaaagc ccggcaggta caccctcaat aatggttgtc agttgggggc cgtgtgattc 1973401 tccggctgtt aaatatctca tgacttcttc tcccttcatc gcattaacgc ttttaagtaa 1973461 gactactata acatattttt cagcaaaaag tcagtctatc ttttttgata aaagaatgta 1973521 tcggctggga ctaggccaaa tttctcggga ttgaagattt gctcggtgct gccgacaaaa 1973581 agaactccat tcttcttcaa gctatgtgcc atttttaaat acagctcttc cttcgcgctt 1973641 tctgtaaaat aaataaatac attgcggcac acgattaagt caaagtcttg ttcataacga 1973701 tccgccagca aattgtgctt tttgaatgta atattctttt tgatttccgt tttcacttca 1973761 taacttctat ttgcgttttg cgtaaaataa cgatctttca cagatagcgg cacttcctgt 1973821 aaagaccgct cctgataaac gccttttttc gctttttcca atgctttttc atcaatatcc 1973881 gtcgctaaaa tctgatagcc cggaagacct ttttgctggt ccaaaagcat ggcaagcgtg 1973941 tatggctcct cccccgttga gcaggcggca ctccaaattt ttaaaggcct agaggtcttg 1974001 attaacggca gaattgcagt ctcaagaact tcccatcttt tataattacg ataaaattct 1974061 gaaacattga tcgtcattct gtccaatgtt tcatttaaga gagcttgatc cttttccaat 1974121 gccgcagcaa agtccttaaa gctttggaac ccctttttct cataaagtga cgttagcctt 1974181 ctcttcattt gtgcttcttt atatagtgtt aaatcgactc cggttaattg tttccatttc 1974241 gttgtaaata cgctgtatgt atccatctct actctcccag tctcgctgtc tttttgtcct 1974301 agtatagctt gttttatcag gaaattgtat tgtttcaata aaaaaatcag cttttcagct 1974361 gattttagat cgttgggaaa ggcagaggtc tgatgcacac tgccattcaa ccctttattc 1974421 actttaatgt aaacctttac aaaacagaac aaaaaccggc ggcgttatat gttgccggct 1974481 ctgttgctta ttttcacaat gattaataga tccagcctgc cataagctgc tgatatgata 1974541 ctaattcttc attcttaaag aaaatgttaa tctcgcgttc tgcactttcg agagaatcag 1974601 agccgtggat gatgtttttt ccgacaaaca tgccataatc cccacgaatc gtaccaggta 1974661 aagcttcttt agggtttgtt ttcccgatca gctgtctcgt cacttcaatg acattttcgc 1974721 cttcccacac cattgcgaat acaggtcctg aagtaataaa ctcaacgagc tctccgaaga 1974781 aaggcttacc ttgatgttcg gcgtagtgtt tctcagccat ttgttcagtc actctcatta 1974841 acttggcgcc agctaattgt aagcccttac gttcgaatct agataaaatg tccccaatga 1974901 gctgacgttg gacaccgtct ggtttcacca tgataaaagt cttttccatc atattctcca 1974961 ccccatcatt atgtatgtat aggctttcac actgcacacc gaaatcgtaa catctttctg 1975021 ataattaatc aatccggggc ggagaaattt cttaatatct acaaaaatta aaattttctt 1975081 ttaccgatat attttgcgat ggctgcaaga gacgagcgtg cgcgccctcg aggaagcgtg 1975141 tttaatttct gaaaagcttt ctgcagatac atttcgctta ctgccataga tgcttcaatt 1975201 gcatctgttt ttttgatttc ttcaatgatt ggttcaagct gttcctgcgt tgtctcactg 1975261 ttaatcaatt taagctggtt ttttaatgca ggatttttca gggcatacag cactggcaat 1975321 gtgacgtttc cttgaagcaa atctcctcct acgggtttac ccagctcttc ctcagttgaa 1975381 gtaaaatcaa gaatatcatc aataatctga taagacatgc cgacgtaata cccaaaccag 1975441 tacaatgcct tatgaatctt ctcatcagct ccagacgcaa tggcaccaag ctggcagctg 1975501 accgcgatca agagagctgt ttttcttttg atacggcgga gatacgttct gagattttgt 1975561 tccatgttgt atttgtcttt gatctgctca atttccccta gacaaacttc aacgatcgtc 1975621 tgtgacaaaa tcctatgggc tttcggttcg ttaattctcg tcatcatttc aagagatccc 1975681 gcaagcatat aatcgcctgt gtacatcgca atacgattgt cccactttgc tttgattgtc 1975741 ggttttcctc ggcgaagctc tgcatcatca atgacatcat catgaaccaa agatgccatg 1975801 tgaatcattt ccagagtgac ggcgacatat ttaatcttat taatatcata atcgccaaac 1975861 atgccagaaa gcagcacgaa aacaggccga atacgtttcc ctccggcctg cagcaggtga 1975921 agacctgcct cgcttaaaag cgggtaatcg gaacgtacgg tttgttcaag ttctctttcg 1975981 attacatcaa tatcgtcatt taaaaaagag taggccattt taaatttcat atcattcacc 1976041 caaacatctg tgttttcatt tccatccgat atgcgtggca gcgactccgc cagtaaacga 1976101 atgatattta acatttttca ggcccgcctc ttcaaacagg cctgccagtt ccttcattcc 1976161 agggaaatct ctggctgatt cttgaagcca agaatattct ttatagctct tcgcaaacag 1976221 tttcccgaaa aacggcataa tatacttaaa gtacataaag taagcctgtc tgaatccgaa 1976281 catttccggc tgggacgttt ccagacatac cacctgcccg cccggcttca ctacacgtct 1976341 catctctttc agtacagtca agtaatcagg gacattgcgg agtccgaagc caatggtgac 1976401 ataatcaaat gtatcatcat caaaaggaag ctccatcgca tttccgtgca gcagttcaat 1976461 ttggctgaat ccgccgtctt ttactttctg ctcgccgaca ctcagcatat tttcactgaa 1976521 atccaagccc ttgatctcgc cgcttttgcc tgccgctttt gcaagagcga tcgtccagtc 1976581 agccgttccg cagcagacat caagtgcttt tgcgccttcc tttacattca tgatgcgcat 1976641 cgttttgtcg cgccattttt tatgctgctg aaaactgatg acagagttca tttggtcata 1976701 atttttatat attttttcaa atactccgtg tacgcgctgt tcttttgagt cctgcataat 1976761 ggtttaccct tcttccactt tctgatgata ggtttgatct tggctgattg tcttcagacg 1976821 gtttattaaa atgttctgaa taggtgaatt tagaggcaga agtgactcaa tgctgttttt 1976881 cgctttttta aaacaatctt ctaatatctc ttcttttgtt tttcccagct gtataaaact 1976941 gccgatcaca tccagaaatg catcatttcc gttcataagc cgcttaaata caaaaaaatc 1977001 actcgacagc tttttccagc gcgggaggtt gaagtgttcc gccacacgat ggaataaagc 1977061 tgattcaacg atgccgacac tttcgaaaaa atcgttttcg tccttgaaag aacggtcata 1977121 cagacgaatt ttatgttcgt tgatttcttt aatggctgta gcaagcgtcc gaatcatgta 1977181 gatatccttc atttcagata gtaaagagta gtacagcccg ctgaaataat cgcccgcgag 1977241 aacagtcaat tggcggtttt tgttttcgtc tcgttttatg actctagctg tcgtcacttc 1977301 atcatgggta tcaagggcgc tttgtacaag catcgctgtt acaatataat tttctctgtc 1977361 gttgtttttt atgtcggctt cttcaaataa agcatgaaaa agaagaagct tatcctcatc 1977421 aattttcggc gcagaaatat gcttcgctaa ataaggatga gacagctttt gttttaattt 1977481 cgtgttcaga ttggctaaag ttccgtagat gtcttgcaaa aatatcaccc ttgtccccaa 1977541 attcacattt atttcttaat ctatgtatga gttttatctt ttcattcgct tacgcaggta 1977601 tcattatagc ataaaaaaaa gaaattggct gtatcctccc gctgtttgcg agcatttgct 1977661 tttaacagcg gggacagcca gcttattttt tttcgctttt catttctccg tacgcggttt 1977721 gaatcagtgc ctctcctctg actttaatgg cagaagtatg ctctgtaaac tgagcgatga 1977781 tcacttctcc cttgtcgagt ttttcggaat ggtgaaactt tgtgtctgtt cctcttgtca 1977841 ggccgatcac attcactccg tcctcaacgg ctttaatgac gacaaaatca cttgaatgct 1977901 tttggttcat ttatagcacc ctctatcttt attagtcctg gcgtttaata tgttccaata 1977961 cttctgcacg ggcagcggca tcatctttaa aaacgcctct gactgctgaa gtcacagttt 1978021 tcgcacccgg ttttcttaca ccgcgcatcg tcatgcacat gtgttccgct tcaaccacta 1978081 ccattacgcc atgcggatca agcgtttcta cgatgctttc tgcaattgta gaagtgatgc 1978141 gttcctgaag ctgcgggcgc tttgcaacgg cttcaacggc acgtgccagt ttgctgagtc 1978201 ctgtgacctt tccgcctcgc gggatatatg caacatgtgc ttttccataa aagggaacaa 1978261 ggtgatgctc acacatagaa tgaaacgcta tatcttttac aagaacaagc tcctcatggt 1978321 tttcaccgaa gatagtctgg aaatgttctt ttggatcttc attcaagccg gagaatactt 1978381 cggcatacat ctttgcgact cttttcggag tatcaagaag cccttctcta ttcgggtctt 1978441 ctccgatcgc ttctaaaatt tgacgaacag cttgttcgat ttgctcttta ttaacttctt 1978501 tcatgttcta tgtcctccac caatgaatac atttaatttc gattctagca catatgcccc 1978561 gctaaaagca aagtgaatgc cctgtcagga agcccatgct cttgaaatat gaaaagcccc 1978621 ttagaaaggg gcttttctgt gaagaaataa agtgtatgta agctagatgc atacacgatc 1978681 tatattcaca attattttcc ggcaactgcg tctttaagcg ctttacctgg tttgaaagca 1978741 ggtactttgc ttgctggaat ttcgatttct tcacctgttt gaggattgcg tcctttacgt 1978801 gcagaacgtt cacgcacctc gaagttacca aaaccgatca gttggatttt atcaccgttt 1978861 ttaagtgcat ctaagatcgt atcaaaaaca gagtcaactg cttttgtagc gtctttttta 1978921 gacaattcgc ttgcttctgc aaccgcattg ataagttctg ttttgttcat gcctttcacc 1978981 tcctcccaaa aggatacatt cagttcgttt attatcattt cttcacagtt cagtctgatt 1979041 ctaaacctgt ctcagaaaaa aatgagagca agtaagagaa agacaattaa acggcttttt 1979101 aagaaaaact gcactctgag gaatgtttgt ccaacaaagt gaagaatttc tgtatgtaga 1979161 gtaacacata taaaaagcca tatcaagcat tttaaagcgt caatcccttg ctcgtcaagg 1979221 atttaaggtg atttaccgaa cgaatattcc tttttttcct tttttcatcc tattccttga 1979281 tccttttcca ttattaagag caaagaaaaa agacctccca ttctataaag aggtctaccg 1979341 gtattacagg atgatggcga ttaagccgcc agagccttcg tttatgattc tttctaatgt 1979401 ttcttttaat ttataccgtg cgttttcagg catcaatgac agctttgcct gaatcccttc 1979461 tctcacaatt gagctcagcg accttccgaa gatatcggaa ttccagatgg agagcggatc 1979521 atcctcaaag tcctgcatta aatagcgtac aagctcttca ctttgttttt ccgttccgat 1979581 aatcggggcg aattcgcttt cgacatctac tttgatcata tggatcgacg gagcgacagc 1979641 tttcagcctc acaccgaatc gcgagccctg ccttataatt tccggctcat cgagactcat 1979701 atcagctaaa gcaggcgctg caatgccgta tcccgtctgt ttgaccattt ttaaggcatc 1979761 agacacttga tcatattctg ttttcgcatg ggcgaagtct tgcatgagct caagcagatg 1979821 gtctcttcct ctgatttcga cgcccacaac ttcttttagg atttgatcat atagatgatc 1979881 aggcgcgtac aaatcaattt ctgccacccc ttggcccagc tcaattccgg ctaatccggc 1979941 actttcaatg aattcaaact cgctgaattg gccgacaacc ctgtctacgt cccggagccg 1980001 tttaatatcc ttaaccgttt ccttcacgga ctcctgatag ctttcacgca accaatggtt 1980061 ttctttcagc accattaccc agcttgggag attgacattc acttctagca ccggaaactc 1980121 gtagagggcc tctctgagca cactcagcac atctgattcc cgcatgctct ctacactcat 1980181 tgccaatacc gggatatcat atttttcgct taaatcctgg cgcatggctt ccgtttccgg 1980241 gtgatacggc ctgactgagt tgatgaccat aataaaaggt ttgccaacct ctttcagctc 1980301 ttcaatgact ctttcttcag cctctatata gtcacttctg gcgatatctc caatggtgcc 1980361 gtctgtcgta atgacaactc cgatggtcga gtgttcttga atgacttttc gtgtgccgat 1980421 ttcagcagcc tcatgaaatg ggatcggttc ttcgtaccaa ggcgtattga tcatccgcgg 1980481 cccgttttca tcttcatatc ctttagcgcc gggcactgtg taacctacac aatctactaa 1980541 tcttatattc acatcgagtc cgtctgacac atgaacagac atcgcctgat tcggaacaaa 1980601 tttaggctct gtagtcataa tggttttgcc ggctgcgctc tgcggcagtt catcctgcgc 1980661 tcgggcccgg tctgcttcgt tactgatatt cgggagcacc acaagctcca taaatttttt 1980721 aatgaacgtg gattttcctg tacggacagc acctacgact cctaagtata tatcgcctcc 1980781 tgttcgttca gcgatatcct tgaaaatatc gaccttttcc aagtgatccc ctcccggact 1980841 tcctatcctt ttcaatttta ttaagctctt tcaatcaaac acaggacact atatgtgtat 1980901 gacgttgtcc tatttgaata tgacatcttt agaaaatttc tcatcctcaa tctattaata 1980961 taaaaaaacc tttctcccta tttgtatgca agggagaaag gttcattcct ttttcatatc 1981021 attttctaaa aaaacaggtt cctgtttgtc atttaccgta tattttacag aaaacgcggg 1981081 gacaaagggg gtttcatgcc aaatcatatc ctggatttca gtcccgggtt taaacgtttt 1981141 tttgcttttt ttgaggcaag aagccagctc agtccggtaa tcggcatata tttctccgtc 1981201 tccgtcaatc ataagcggca aggaattccc tgagattggg cttgtcactg taagagagct 1981261 gccatcccca agcttcttct catcgagtgt aaataaatca cgagatagca catccttgta 1981321 aggcggatat tgatgctcct gacgatacat ttggatgcgc aatttcacat cgcgaatttt 1981381 ttctgccatc tttagatcaa ttaatttaac agtcggatcg ttctctacgt caacaagcac 1981441 gtattgatag tctcccccgc tttcaaatgc cgtacttgga ggttcagcta tgtatcttgg 1981501 cgctaaccgg ttaaagtcta tcggatattt ttgatatagc ggtgtcgaca tatctttggt 1981561 ttgaatagga agcagccctc catttgcctt ttgaaattca tcaacagcag attgaacctg 1981621 ctttagctgg tcttgataag gaatggcatg cacactgctt ttccgttcat ttggatataa 1981681 acatccggat aaaaacacga ctgccgcaaa aatgattgcg cacttcagtt tacccataca 1981741 gcacttcctt ttacagcttt attcattgac agggccgcta aaaaccacga caaacacaat 1981801 aattccagat atgagcatac acatgtatgc gaatgatgaa atcgcaatct tcaaaaaacg 1981861 gttttggcac ttaaagcggc ttaaatagat ggaagctaca gccagaaaca tcagacccat 1981921 ggaccctaga gcaaaccaca ttttcatcaa tgccagattc aatgacgtgc gcctccccga 1981981 tatgtaagat ataagcgtta tattatattt taatatacag cgccggaaaa gatcaaccag 1982041 attttccatc cattgataga acaaaaaaac tgaagcaaag agggggacct tcgcttcagt 1982101 caacttgact atattcacct gcacgtttaa gaaacactct cttggacttc gatgctatag 1982161 tatgcgactt ggcatacaga tgcatcctct attgcctaaa tcggcaaaat gtttcaggag 1982221 atcccaagac ttgggtgttc ttctgttttt cgggctttcg ttcaattaag atatgcgatt 1982281 caccatttga ttgacacttt tacttcactt gattttcaaa cgtatttacc aaatcctcca 1982341 tctcgtgggt tttccctctc gccattaaag attcaacagc ggtttccact ttttgtccgt 1982401 tgaataggac ctgatggaga gcttctgtaa tcggcatttt aacatcatat ttcttcgaaa 1982461 gctgataagc cgctttcgtc gtgcggacgc cttcgactac cattcccatc tcttcaagaa 1982521 catcttcaag cttgtaccct tttccgagca aattgcccgc acgccagttt ctggaatgaa 1982581 cacttgtgca cgtcacaatc agatcgccta ctcctgtcaa tccagagaac gtcaagggat 1982641 ttccgcccat tttcgttccg agtctcgcga tttcggcaag tccgcgtgta atcaaagcag 1982701 ctttggcatt gtcaccgtac cctaaaccat ctgtaattcc tgcagcaagg gcaataatat 1982761 tttttaaagc ccctccgatt tcaactccga taatgtcagg atttgtgtac acccgaaaat 1982821 tgtgattaat aaatagatcc tgcacctctt ctgctgccct catgctcttt gaagatgcag 1982881 taacagttgt ggggtgccgc agccctactt cttccgcatg actcgggccg gaaaggacaa 1982941 cgatatcttt tctgacatca ctcgggagct caatttccat aatttcagaa atgcgcagaa 1983001 gtgaatctgg ctcaataccc ttgctgacat gaacaaagac tgcctttttc gttataaaag 1983061 ggacagcctg tctcagcact tcccgaattg cttttgtcgg gaccgcaacg ataatgacat 1983121 ctgcgtctga aacagcctct ttcatatctg ttgttccttt aatggatgta gacagcttaa 1983181 cattcggcaa ataatctttg ttttcatgca actcattaat ttgatgaatt aaatctgcac 1983241 ggtgagccca cacacacact tcatttccat tatcagttag aactaaagcc agtgctgttc 1983301 cccaactccc cgctccaagc attgtgactt ttttcatgtt tgattcacac ctttttattt 1983361 tctagctctt gcaaatattt tgattggtgt cccctcaaaa ccgaacgcgt ctctgattcg 1983421 gttttctaaa aaccgttcgt atgaaaaatg catcagttcc ggatcgttta caaacacaac 1983481 gaagcttggc ggctttaccg acacttgagt cgcatagtaa attttcaaac gagaaccgtt 1983541 atgagtcggt gtcggattca ttgccacagc gtccatgatg acatcattta agacgtttgt 1983601 ttgaactcga agtgaatgat tttcactagc tttgataatc gcaggcatca gagtatggat 1983661 ccgttttttc gttaaggcag acataaatag gattggcgca taatccagaa attgaaaatg 1983721 atcgcgaata ttttcttcaa attctttcat cgtgctctca tctttgtcaa cagcatccca 1983781 tttgtttacg acgatgacga cggccttgcc cgcttcgtgt gcataaccgg cgatacgctt 1983841 gtcctgttca ataatgcctt cttcgccatc cagcacaacc gccacgactt ctgagcggtc 1983901 aatcgctttt agcgcccgca gtacactata cttctcagtc gtttcataga ctttcccttt 1983961 ttttcgcata cctgcagtat cgacaatgac aaactcctgc tggttgtaag taaatgacgt 1984021 atcaacagca tctcttgtcg ttccagccac gttgctgaca ataacgcgtt cttcgccgag 1984081 catcgcattc acaagtgaag actttccgac atttggacgt ccgatcagac agaattgaat 1984141 aacttcttca ttgtatttcg tttcaggaat gtttttaaaa tgctctgcaa cggcatccag 1984201 taaatcaccc agtccgagtc cgtgtgttcc cgaaattgga tacggctcgc caaagcctag 1984261 cgaataaaaa tcataaatat tcgctctcat ttctgtgtta tccagtttat taaccgctaa 1984321 aacaacaggc ttttttgtgc ggtacaaaat tttcgccact tcttcatcag cagctgtcac 1984381 gccttcacgg ccgttcacca taaaaataat cacgtccgct tcatccatgg cgatttcagc 1984441 ttgctggcga atctgcgcta aaaacggctc atcaccgata tcaataccgc ccgtatcaat 1984501 caaattaaaa tcataattca gccattcagc cgagctgtat atccgatccc ttgtcacgcc 1984561 aggggtatct tctactattg aaattctttc tcccgcaatc cggttaaaga ttgtggattt 1984621 tcctacattt ggtctcccga caatggctac gacaggttta cccatagtac ccttcctttc 1984681 aatccagccg ctttcatttt tacataaatt ttcaaccggt tattaaaatc atttcattca 1984741 cttttatgaa aagaaaccct tcagaggaag ggcttaactc atttattata tcagttttta 1984801 ctgggatcac aactattctt aaaaatgttt cacgatcaaa tacacgtcat ctccgattct 1984861 gtgagctatt ccatcaagga tcgcctcaag atttttagcg aaaagctcca tctccttttg 1984921 gtcattgcaa aaaaagacag gtgctccccc tgcaacccga tttcgatttg tcgtgattac 1984981 agacaaaatc actttcgtaa gagattcact catcctatca ccttatcctg attcttgata 1985041 aattcagtcg gcattctaat cgcattttcc agggttggaa cattgctaat aatttgaaca 1985101 gccgtttcgg gatggtgaat ttgcgggaga acaaatactg ccactctccc atcatttaaa 1985161 tcccgttttg caattggtgt caaagatggc tctcctgaat cccgataaac cccgagcaca 1985221 ttggaaacat caaataaaat ggcctgacgc tgccctaaat ttgctatcgt cgctgctgaa 1985281 ttaaagtttt tcggcgtcaa aataaagccc atgccatgct ttaaaatcag ttcctgtttc 1985341 tctggaagcc cgatattcat catataaata ttatcaacaa acagtcccgg accgtcaaag 1985401 cgcggcttta tgtactcgat atctacaata tccttcaaca cactgcccga cataaacttc 1985461 atggccagta aaaaacaaac gacagccgct atgactgcag cccagatgga taaaaacaca 1985521 tacgcagagg ttgtcaaaag cgctgtaaag atcacaatat aatttctgct ttcaaacgca 1985581 atggcaatcc cctcaatata tgtgcttccc cttgagacaa gttcatacga atccatttgc 1985641 gtcaatgtgt tccgctccat gtttcggaca tctctaaatt gcgtcgctgc caatgttaaa 1985701 aatgtgatgg ccgtaaattc ctcctgcaaa agcgccggca taataattgc acctaaacca 1985761 gccgctatca accccagtgc gatgtgaatc actttcccat gaacataggt cggatactgg 1985821 cggtaatccg ttttcagcat ataaagcctt gtcgcaattc cggcaatgac cccagcaata 1985881 atcggataga tgtaatcact catgacattt tggtagctcc tttgtttgat cttttgcttt 1985941 tctgaccaat ctggcttgcg aggtgttcgt atttagatat gccaaacagc aatatcatcc 1986001 ccgcagaaca cgcattcagc cattgaaagc cgccgacagc catagccccg gccaacttct 1986061 ggatcacaaa tgaatacacc agttcgcctt ggcacatccc taggacaaat aagacaagct 1986121 gcttctcaaa attcctttca acagaagctg ttaaaagcac tattaatata acagcagccc 1986181 actcaggttt tatgatgaac caaaccgggt catataatgc aaaaagataa acaaacgcat 1986241 acgcggcaac aagcgtcaga tagaccatga tgtaacgaaa acgatacatt cccaaatacc 1986301 cggcatagac acatccgcaa acgaaaaaca tcaaatatgc agcattcagg gaaaaatata 1986361 aagcgatgtc atgtatgctt agaataatat tagttaaaat aaagacagag acggcaattc 1986421 gtcttttcgt cttttcaaaa ataaatgttg tcagaaccca cagaaaccac attgaccaat 1986481 agtaataaaa ttgttccatt ttacttcctc catattccca gtatggagtt caagcacatt 1986541 ttttaaacaa tcgatctcac attaaggagt atgatcatgg gaaaagacag acaagagaaa 1986601 aaactcaaag cttcaggcag agtcgaatca gatcgcgacc agtccattca ctatgacgga 1986661 gcgacaagcc ttgaacaaaa cggaagattc aaaaagcgaa aatcataata caaaaagccc 1986721 aaaccacata tggttttggg cttttatcat ttatcgcaca ctatagcttg atgtattgac 1986781 ccctctctct gtgagccaat gatgggtttc acctttgatc acaaggggcg ccttttgtaa 1986841 atcggcaatt gttctggcac ccagcacggt cataatcaac tttaattcct caaggatcag 1986901 ctgaatctcc tcaagcagtc cttcctcacc gctgtcagtc agcgctttta aaaaatgccc 1986961 tgccattccg gtgcaagagg cccccagcgc aattgccttt gccacgtcaa gcgcatcttg 1987021 cagaccgcca gaggcgatca tggtgcttgc aggaaactca gagcggattt ccgccaaact 1987081 tgcagctgtc gaaatgcccc acgaattaaa aaaggagatt tgccgctgtc ttcggagatt 1987141 ttcgattttc gagaaatttg ttcccccgta accgccaatg tcaacagctg cagcaccagc 1987201 ttcatacagc tttcctgctg atgctttgct cataccgaag ccgacttctt tcacaatgac 1987261 cggtacactg acccggctgc aaatttgttc aatgcgtttc aatgcgccgc taaagcttct 1987321 gtccccttca ggcatcacaa tttcctgaat cacattgagg tggatctgca gtgcgtttgc 1987381 tccaatcatc tcaacggctt cctttgcctg agcagccgtt gcctcgcttc ccaggttggc 1987441 aaaaatcagc ccgtttgggt tttcctttcg aacaatttca taggaaagac gctctgatgg 1987501 atcttttaat gctgacattt gcgatcccac agcaagggga attccagcct gagaagccgc 1987561 tcgcgcaagc gatttattaa tctcatatgt aagttttccg ccgccgccag tcattgcatt 1987621 gataaaaatc ggcgaactgc ttgaaagttc gccgattttt gtggaaatat ctacttgttc 1987681 taatgcaaga tcgggcagac tgacgtgaac aaacgtaata tcatcaagac ctgtttcccg 1987741 cttctggccg atggacaagg catgattgat gtgttgtctt tttcgttctg ctcgagtcac 1987801 gtttatcacc aattatttta gtttattcag cttatctccg atcagatctc caagctggaa 1987861 gccagtgctt gtttcttcct tcgcttgata ttgacggtaa tcttcctggt cagctttagg 1987921 cgtttcttca agttcacgca tgcttaatga aatgcgctcc tcattttcat tcacatcaag 1987981 aaccttcact tttacagtct gtccttcttc aaggacttca tgcggcgtgc cgatgtgttt 1988041 attggaaatt tgagaaatat gaacgagacc ttcaacacct ggaaggattt caacaaaggc 1988101 accgaagctt acaagacgct gtacagttcc ttcaagcaca tcgccaggct tcactttttc 1988161 gccgatttgg ttccaaggtc caggcagtgt atctttgatc gataaagaaa tacgttcatt 1988221 atcacggtca accgataaca ctttcacttt tacttcttgt ccctcttcaa caacgtcaga 1988281 cggcttctct acatgagagt gggaaagctg tgaaatgtgt acaagtccgt cgatgccgcc 1988341 aatatcaaca aacgcgccaa agtcagtcag gcgctgtact ttgccatcaa gtacacttcc 1988401 aacttcaaga gactgaagaa gttcttgttt tttattcgct tgttcacttt caacaacagc 1988461 acggtgtgaa aggatcacgc ggtttttatc acggtcaagc tctacaacga gcagtgacag 1988521 tgtttttcct ttatagtcag tgaagtcttc aacgaaatgt gcttcaacaa gtgatgccgg 1988581 aataaaaccg cgaacgccga tatcaacgac aaggccgcct ttcacgacat ctttcacttc 1988641 agcttcaaac acttcttttg tttcaaattt tttctcaagg tcttcccaag cgcggtctgc 1988701 atcaacagca cgtttagata aaatcaaagc atcgtcttcc acttttgtta ctttcaggtc 1988761 aagctcgtcg tctactttaa caacatccga tgctttctct acatgaagac ttgataattc 1988821 actgattgga ataataccgg attgtttgac attgataatt tctacatcta catgtttgtc 1988881 ttctaccttt gtcacaatcc ctttaactac atctccaacc tctggcactt gaacatcaat 1988941 ttgattcatt tcctctgtca tttgaataac ctccttggtc caaacctaca cagcttaatt 1989001 aaaacggttt gaaagctgaa catataacat gcccgctttt agccgaatat gtattaaaga 1989061 atcatccaaa aaagtttttt gaatgatcaa taaaaagttt tattagtatt aacttctaat 1989121 aaaaggacag gtttgtcaag caataacatt ctatcttcgt tgaaaaattc aaaaaaagtg 1989181 gcatttgcca tcctcagcgg gacttttgct ccacagcctc gaggatttta tcagctacct 1989241 cttgaatgga aagcgatgtc gtgtcgattt caagagcgtc ttctgcttta cgcagcggag 1989301 atacttcgcg ctctgaatca agcttgtctc ttcttgcaat ttcctcaatt aatgtttcgt 1989361 agttgacatc aaagcctttt ttcacatttt cttcataacg gcgtttcgct ctctcttcca 1989421 cagatgccaa aagaaagatt tttacttctg catttggcag cacatgcgtc ccgatgtcac 1989481 gaccatccat gacgacgccg cctttttccc caagctgctg ctggcgtttc accatttctt 1989541 ctctgacact tctgtgcttg gccgcaattg aaacttggtt gctgatttca tctgttctga 1989601 tcgcctcagt tacatcggtg ccgtttacaa acactttttg tccatctttt gttgtaatca 1989661 gctcaatgtc tgtccgcttt agcagctcag ccagtttttc ttcatctgtc agatcaacgt 1989721 tttcctgtaa agccgcgtac gtaatcgccc gatacatcgc tcctgtatca atatatatgt 1989781 acgatttttt ctcagccaca attttggcaa cggtgctttt ccccgcagct gccgggccgt 1989841 cgattgcaat cgataatttc ttttccataa ttcctctcct tgctcttttc tcctctaagg 1989901 attgtatcac gaactttatg aaaaagggtg aaaaattgat gaataattaa tgtttgaagg 1989961 tttcaatcct attgttttcc tccattttat ccaccccttc atattgaatc acttttgata 1990021 cgtatggttc aatatgctga tagtgaaaaa gaaattggac accaagtaaa atgatggcct 1990081 gaatgaacaa taatttgatc agcagccgtt caaatgtttt cattggagca cctccattac 1990141 aaatagtatg gaagtgtttg ccgatgttta ttccattcgg gcctttcttc tcttatttaa 1990201 ctggcgcctg atgcagtatt gaagcaaagc ctgctggtca cctgctgcaa tttctgaata 1990261 ctctaaagtc atttttcgtt tttctgactt ggggtcatta aagattcgtc tgacaactgc 1990321 ttctgtttct atttgacgtg tgtgctcctc ttcaggaaga cggatgatca ggcgcaatga 1990381 ttcccccgat tgaaaagaaa ggccatcagc taaaaccacg gcgatgccgc ctgcactgat 1990441 gttataggat agtgtgcgga tctcttcttc atttcccggc tgaatttgca catctaatac 1990501 cgcatcagtt cttacatatt ggcggcgctg gattcttttc attttttcac ggggaggcat 1990561 ttcaagacag atcatttgaa gtttgtcctt cactttacct tttatacggc ttataaagcg 1990621 ataaggaact tcgtcttttc ccacaaactc taccgttact tccatatcgt tatgtaaaat 1990681 cacagttcgc cctgtaacta catcaacagg atacgcgatc aaaagttcat tgttttcgat 1990741 gctgaccgcc ttgctttttg cctttttcaa ttcattttct tctatatatt ctaaaagtac 1990801 attttctcca atctctatca ttgacttcac tctttcgcat tcaatatact cacgttttta 1990861 ttaaagcacg taatgaaaaa aaggaaaaga catttagtcc tttcctcctg tttttatagg 1990921 tctttatata taggttctgc attttttagt ttttcaacct tttcttccga tccgtctttg 1990981 gcattgatat acattctgaa tgtgtcattt tcaattgtcc caagcatttc gtagcataac 1991041 acttcttgac ctagttcatt tgtaatcaaa gcgagccttg tttctctcac ttgtacattt 1991101 ttatttaatt tagactttgc ctctgcttca gtaattgcag gcttaggtat ggttcttttt 1991161 ctgtgagatg tgaggaagtc tcttgctgaa aagccgacaa cctcaccgtc atccaaggcc 1991221 actttcatac gaattgcctc ggggtacatc cggactttat tttcaacagg aacatatgaa 1991281 aatacaccga ttttatcata ttgggcactt tcatcaattt ccaaatcatc tgtttcaaat 1991341 ccgtttttct ttaaaaatgc aagcgctcgg ttcgatccgt catttaaact gattttctga 1991401 tctttcactt ctctgttttg gatcaagtat accggatgcc cgcccttctt cgtaatatcc 1991461 atataaatca ctgctttatg gtctgggtct ttcatgctga tgctatatac atcgcgattt 1991521 gttttttttc cgctctttac cactttaatt gaataattgt catctggggc aaagcgctca 1991581 gcaatttgtt ttgcttcctg ttcggaaatt tgttttccct tcagatggct gaagcctttc 1991641 tcttcttttt tcgtactggt gaaactcggg ccaagatcag tgccagtgga gaatgcacca 1991701 acattttttt cgactgtttt aaagctgttg ataatcgtat tatcactttg tttttcgtca 1991761 gaagccagag ccatttctac gtccatccag cgaaggtttt tgctcatgac aaggtgctga 1991821 acatgacgca attcattttg tatatcttcg gactgctgat atagcttatt tagtgatgta 1991881 tactcgtttt tatcaagcgg cttttggtcc aaatctctga ctgacgtttt atagctgaaa 1991941 tcgccgatct ttgataatag ctcttcagtt ttattaaacg gcattaatgt aagcggcagc 1992001 tgactgacgc tgttatgagc ttctgatgta atcctccaca catcgatcaa tgcaggcgac 1992061 agtgattttt ggctgttcat ggcaagtgtt gttccgattt tatcatgaag ctgatccacc 1992121 tgataggtaa gctcatgaaa cgcccgctga tagttatttt cagcatgaag aagaactgcg 1992181 tctttttcct ggtgttcttt gtatccccag tagcctgtac cgactattgc aataccaagc 1992241 acggcgatta aaattcctct gatcatttat cacacctctt tttatgcttt ctcatatctg 1992301 ctactcacag aaaatgtgtt taccgattct tttaatctgc ggacgccccc aaatccacgg 1992361 acttgtagcc gtatccggat taaagtagta aagtgcttcc tctgatgggt cccagccatt 1992421 gatggcatcc agcactgctt ctcgtgccgt ttcattcggc tgcatgtaaa tttgtccgtc 1992481 ggctactgct gtgaaggcaa gcggctcaaa aataaccccc gctactgaat ttggaaataa 1992541 cgggctgttc aaacggttta aaatgactgc tgcaatagca acctgcccct cgtacggctc 1992601 gccccgggct tcgccataaa ccgcttgagc aagcagcctg atatcgttgt tggaaaatcc 1992661 accaggcatg ttcgctgcta ccgcatcctg ttttcttgct tttgctggtg tattgttttg 1992721 ctgtttattc gcattcgctt taggcttctg cgttgttttt tccgcaggct gtttctgccg 1992781 tgcttctgct tgttgtcttg ccttttgtgt tgctgctttt gatggtttcg tctgatactt 1992841 tagcggaatt tttccgtaat gcgtgaatgt attcccttta ttgagctgtt ccatgacata 1992901 ttcacgatag tattttgatt tacatattaa ggtttgcttt gttttagctc ctacaaggcc 1992961 gtcaacctct tttaacccga attgatcctg aaaatttcga actgcccagt acgtccccca 1993021 tccataaacc ccgtcaattt ttccgttata atatccgttg tattgaagac gcgcctgaag 1993081 ctcgaccaca tcatcccctg ttgcccctct ttgaatgacc tgattcgaaa aggcagagat 1993141 cgtttcagta ttaataaacg tcgttattgt aaaggaaaaa aggatgagac atgccataat 1993201 cgatcctttg gacttcatct tttcaagcct cctactgcaa atttttaagt gtaatcgtat 1993261 tttctgtaac gaggttattt ttatacactc tttccttgtt atccctcaga acataaaaac 1993321 tgcacacaaa aaagccgcac ggttgctgtg cggcttctat acttgcatca tattaacgga 1993381 acgggctttt ttcgctttac gcaaaccaaa ccaccataaa aataccataa atggaagcat 1993441 ataataaatc caattgctaa gcgctgttag gataaaatca tatgatccat gcaaaaggga 1993501 tgggacaact aaagaaagag taagccactt tacacgcgcc ttatcagcgg aaaaacgggc 1993561 ttttccaagg taaaatccca ttataacgcc aatcaaggca tggcatgaaa caggcagcag 1993621 cgccctgaca aacgcatgct ccacgccgtg gccaattaaa taaagaatat tttcgagggt 1993681 tgcaaaaccg agtgatacac ttgcaccgta cacaatcccg tcataatgct catcaaagtg 1993741 ggcgtgcggg taaacactga tcatcagtat aaaccatttt aatgattcct ccaaaaaccc 1993801 cgaagataaa aaagaaacga aaaagcttcc gcctcctaca ttctcttttt caagtacata 1993861 ctggataaac atgatgggaa atacaagaac aaccccgaga aaaaacgacc gtagcaccat 1993921 atgtacaggt tcattatcat actgatcttt taaataaaaa taacttaata acgcgatgcc 1993981 gggggcaatt cctgcagaga tgattgcaaa catcaggcaa cctctttcct ttatattcct 1994041 acatctatcc taccatgttg tttaaaattt tacatctgtc tgcacttaaa aaaacaaaaa 1994101 gagcatacga atgcatcata tgctcctcat ctttaatggt tttctctttt ggcgatttcc 1994161 gctgcgatat gccccccgtg aaacctgccg ttttcaataa atatttcatt tgcattgttt 1994221 cccgcagcaa taacaccggc aataaagaca ccttcaacgt tcgtttccat cgtttcttcg 1994281 ttgaaaaatg gacgccctgt ttctttatca atttcaacac caattttttc aagaaattga 1994341 tgatcgggat gatagcctgt catggcaaat acaaaatcat ttttaatggt aatgagttct 1994401 ttctctccgg agcgaaacac aacttcattc tcggtgattt tttcgacaca agctccaaat 1994461 tccatacgga ttgtaccgtt tctgacgaga gcttcaaatt ccggcagaat ccacggctta 1994521 atgctcggag aatactcatt gcccctatat aaaactgtga cacgcgcccc agatttcacg 1994581 agttcaaggg cggcgtccac gcttgaattt ttcccgccga tgacaacaac atctttatca 1994641 aaatacgggt ggccttcttt aaaataatga aatactttcg gcaaatcctc accgggtacg 1994701 cccatatagt ttggatgatc ataatagcct gtggcgatga tacaatatgg cgtcgtgtag 1994761 gtctcttttg acgtctcaat aacgaatgtg ttattttgcg ttttcgtcac tttacgcacc 1994821 atttcaaacg cattaacacg gatgtttttc cgtttaacga cttcccggta atacgataaa 1994881 gcctgaattc tgacaggctt cctgttctct gtaataaatg ccacatctcc gatttcgagc 1994941 ttttcacttg aactgaaaaa ggtttgatgc gtcgggtaat tgtaaatact gttaacgaca 1995001 ttgccttttt cgatgacgag ggcatcaatg ccaatttgtt ttaggtgaat ggcagcagat 1995061 agtccacaag gtcctccgcc tataataatt gctttttctt gaatcatttc tgtcaactcc 1995121 tgcgattggc atttcacttc atattttcta tttccgaata aaaaaatctc ctattttatc 1995181 ataggagatt ttttattttt atgcaaatca tcaacttata tccagcctct aaaacgcgaa 1995241 gcttcagcca ttttgcgaac gccgaccata tatgcagcga gcctcatgtc aattcttcgg 1995301 ttgttagcca tttcgtaaat attgttaaat gatttgacca tcattttttc taatttttct 1995361 tctacctctt cttcactcca gtagaagcct tggttattct gaacccattc aaaataagaa 1995421 actgttacgc caccggcact tgccagcacg tctggtacaa gcagaatgtc ccggtctgaa 1995481 agaatttttg ttccttcaag cgttgttggt ccgttcgctg cttcaacgac aattttagcc 1995541 cggatattat gggcattttc ttctgtaatt tgattttcaa tcgcagcagg aacgagaata 1995601 tcacaatcca gctccagcag ctcttggttg gtaatggtat cgttgaaaag ctttgttacg 1995661 gtaccgaagc tgtcgcgtcg gtcgagtaaa taatcgatat caaggccttc cggatcataa 1995721 agtccgccat acgcatctga gatgccgaca acttttgccc ccgcatcatg cataaatttt 1995781 gccaaatagc ttcccgcgtt tccgaagcct tggacaacga cacgcgcacc tttaatatcg 1995841 atgcctctct tcttagccgc ttctttaata cagatggtaa caccttttgc tgtcgcagat 1995901 tctctcccgt gagatccgcc aagcacaagc ggtttgcctg taataaatcc aggcgaatta 1995961 aattcatcaa ttcttgaata ctcatccatc atccaagcca tgatttgtga gtttgtaaat 1996021 acatccggtg ccggcacgtc ttttgtcggg ccgacaattt ggctgatcgc tctgacatac 1996081 cctctgctca gacgctccag ctctctaaac gacatatccc ttggatcaca aacaattccg 1996141 cctttaccac cgccatatgg aagatcaatt atgccgcatt ttaaactcat ccaaattgaa 1996201 agcgccttca ccgccttcac ctctttttct gttacgttcg ggtgaaaacg tatcccgcct 1996261 ttcgttggac cgacagagtc attgtgctgc gcacgatatc ctgtgaaaat ctttactgaa 1996321 ccgtcgtcca tacgaacagg tatttttacc gttaataatc tcatcggctc ttttaacaat 1996381 tcgtatacct cttcgggata tcccaatttt tccagagcct tatgtattac ggtttgggtt 1996441 gattttaata catcaagttt gtcctcttct gtatgaccgg tgtttcgatc ggctgccatt 1996501 tgagttaacc tcctagaatc ttctgtttct cacatgctcc ctttcagaga atagtataca 1996561 ccttcatatg atctgtgcat agaataaacg ttatgttttt ccatgttttt taacgaaaaa 1996621 aaactgctga aatcagcagt tttccgttgc attcttatga aaaatgagtt tgtatcgttt 1996681 ctacggcatt accgtccata atgagcttac catactcttg caggcgataa atcgttaaag 1996741 ttgtcggatt gccgtattca gccagaaccg ccacaacccc ttcagccgta tgtgacccta 1996801 gatcttcaag gcttaaaaag tactgcccgt catagtggta gacagttccc cctgtgatac 1996861 cgattcgctg taagctttct gaaagctgaa tgatatcttc aaaggaatgg aattgatata 1996921 tgatgtccgc gctttcatca agcttgactt gcatttcgat gtaatcatca tcatactcat 1996981 cgtcttctga atcggcgtct tggttctttg ttacaatcac gaccatccct tgtgcttgga 1997041 gagaatacac ttccactgca atcggtccat tcgcttcaaa gccgagctct gtatttgctt 1997101 cattcatcat atctttaaat aactggtgga ctttaaatga gtccttccag aggtcttctt 1997161 ttgtcaatcc ccggtctgtc aaatcatcga gggttaaaaa gattttgatc ttattataat 1997221 tcagacgctc aagccgcata acgttccctc ctgcctctac ttgcacacaa atcatataac 1997281 acattatatg agatgatgag tcataggttc ttaattgtta tcagtttaca ctgagttcac 1997341 tagtaagaca agcacaatgc agtttttatt gccatacgga tttttgcttt ttagaagtta 1997401 ttctggcccg caaagagtca caatgtgagt ttcaggctca gcacctaaac gaagaggcac 1997461 ttttgtcgtg ccgtagccgt tgctgatcag atatgccgcg tttttaacaa tacctgtttt 1997521 ccccagttca taaggaccga attttccaaa cctgatctgg cctccatggg tatgtccgct 1997581 gagtatcaca tcaataccgt catcttcatt gatttgttca tgaatctccg gattatggca 1997641 aaccagaata ttcagctggc tttcatcaag ttctttgatg gcttcctcat aatgatccat 1997701 ctccatcctg atatcatcaa cccccgcaat cgcaatcgta tgcccattgt atgaaaacgg 1997761 gactgactca tttctcagag tgatgacgcc gtgcgcttta aatatggaat acagcttatg 1997821 ctgcctgact tcataatcat tattccccca cacaaacacg atagggaccc cgaaatgtac 1997881 gagccttttg atgttttcct cgattctcgc actgggcacc ccgccctcag ctaaatcacc 1997941 gccgattata accaagtggg gggcatggct tcgcgctttt tctaaaaggt cttgatcgat 1998001 gagacgtttg tgaatgtctg aaataaaaaa gattgtcaga ggcggcttgc ccttcatctt 1998061 tgataaagga aacgtatgtg tcttcaaatg attgcctttt gctgttgcat acatttttgc 1998121 cgtcattgcc gctgccgcaa cagttagtac accggcaatt ttcactgata gcttcataaa 1998181 aaactctcca ttctttttag aacttatcaa taagacggac aataaaaaaa gacgtttcta 1998241 tcgtttgaga aaacgcccca ttttatttac tttcaaaata tagattaatg tcatatttgt 1998301 gcttcatcat atgaaaaaca gactctctcg ccttccattt atcgggctgc ggccagagat 1998361 cagtgctttt ctgaataatt tcacatctca gtttatggaa atcagtctcg gatttttctt 1998421 cctttttctt gaaataatat gaagtgcagt aggcaaaagc ggttgccagc atccaaaata 1998481 aataaaaggt atggctaagt atttcttgaa gtataagctg aggctccggg cttttgatca 1998541 tgatcataac acataataag cctaggcaga taagtgaagc ccatcgccat ctgcggcatt 1998601 gtgctgcata attttcgaat ttttgttttc gttttaccag cgcttggagc atctgtttgg 1998661 tcggcgcgtc tgtaaactga tccagctgat tccataagga ttccatacgc ttcacacctt 1998721 gtccattttc attgctacaa tatatgaacg taaaataaaa ataataccct attcatccat 1998781 taaagggatg tccaaaactt gtccggtgta aacatcattt ccattcagat gattatatgc 1998841 tcgaattttt tcttctcctg tccggctttt ataatacttc atggaaatgc ggtatagcgt 1998901 ttctttcttt tggacggtgt gcttgacaac gcgattcggc acattttgaa ctggctcagc 1998961 tggctgttct tgctgttgta ctgttgattg ggaagaggaa gcagccgcgg cggttgcttc 1999021 ctccttattt ggcgagtctt ctttttccgc tacagcagtc tgtttcttat cagcagctgt 1999081 ttgctctttt ggcttggaat cttctggctc tttttttgac tccttctgca gtgcggtttc 1999141 tttagtgtct gcggtatcgt ttttatcctc tgatttcggg acaacctcat atttgctttg 1999201 gctgctgtca ataaaaacat cttcataatc gtcatgatta tccgggtggc tctttagata 1999261 aaataaggtg actaaaacga taaccggcac aaatacaaat attactgcga gtactgtgaa 1999321 taatggcgtt tttgttttgc cttgcttttt tttctgttct ctttgatttt ttacagattg 1999381 tcttgtcgga aggctttctc catcatcgac ataatcgtcc gccaatgcgg cgttttgatc 1999441 ttcataaaga ttctgggctt ttcttctctc tactctcgac atgttcgtca tgtttatccc 1999501 tcctcacatg ttcaaaacga atctgacagg caaacacggc atcaatgata aaatgcgccg 1999561 tcatcggaac aaataagttg ccggtccatt catacatcag accgagcaaa aagctgattg 1999621 ctgtcaccat aataaataac agccattttg acaaataccg aaagtgcaga gcggcaaata 1999681 taaggctggc cgtccataaa ccgatatgag tctgcagcac tcctctgaat aacatttctt 1999741 ccgcgaaagc aatcagaagc gttaaaaata taatatgagg gattgacctc ttactgaata 1999801 tttttttatt gattccgccg tcatcatata aatgagacgg aaaccatttc attactgcca 1999861 tatcggctaa aataacaata acagctatag aaacaccata ccagatgatt cgcatatcgc 1999921 gaatgtccca gagctttaat acgtcccgta catcctcaaa aaagaacagt cctgctgcag 1999981 cagcggcaaa gatgatgagt agctgcgtca aatataactg cttcagcata tcatggtcag 2000041 tcatatgctg aatataatct ttttgctgtt tcagttcagc tcacctacag tctgcaagct 2000101 gaatatccgg tgcaattccg aactccagct gtctaatggc gccattttac tccgttcccc 2000161 tttttgttca tacaaggata aatcaaaacc gcaatgtgaa cagcacggga ggtttccgtc 2000221 atcaggctcg tatgattcat caaagtaggt taacagtgcc tgccttaaac agccgtcacg 2000281 ctgaagcaaa aatgatacac ggtgcatttt ttccagcttc agctccatgc gatatgaaat 2000341 ttctttcttc atcagttcaa ctgatgtttt tccctgcata aagagatgaa tcatcatacg 2000401 ggcctgtgtc tctccgacgc catactgaag taatacgtca cgcagccttc tctcatcccg 2000461 ctcctccgtc ttctctagca cacggattac gtcggcgatt tcttcagctg tgacactctc 2000521 catctggata atttgttcct gcaattcaaa atcccctggc gcccgcagca aaatgctgac 2000581 actcggcttt ccgtcgcgtc ccgctctgcc gatttcctgc ataaaagctt ctgccgtctg 2000641 cgggagatga aaatgaatca catatctgat atcaggttta tcgacaccca ttccaaacgc 2000701 attcgtacaa catatcacat caagctggtt atgaataaac tgctgctgaa ttaaaatcct 2000761 gtcccctgac tccaaaccgc catggtaaaa gtcggctctg ctgctcgttt tgcttttaat 2000821 ttcacccgct aattccttag cccatttccg tgttggacaa taaacaattc ccggaccttg 2000881 caggttttca accagctgaa tgaccctatc tattttttcg gcagtatccg ccgcattttc 2000941 aaccctcagt gcgatgtttg ggcggttgac tgagttgaga tggcgtacag catgctgcag 2001001 ctccagcagg ttcatgacat cttgcagcgt ttcctttgta gccgtggcgg tcaatgccag 2001061 aacgggtggg tgtccaagtt tttttctcag ctgtccgagc tttgaataat caggcctgaa 2001121 gtcgtgtccc cattcagaaa tacaatgcgc ttcgtcaata acaaataggc taatcggaac 2001181 gcttttcaat ttttccaata catatggaga ctgtaaagct tcaggagaca agtacaaaaa 2001241 tttatatcga tgaatatgtt ctaaaacaaa ttgtctttcc tgcctgttaa gcatgctgtt 2001301 caaagctgca gcacgctttt ccccccgggc tttgagctgc tgcacctgat cctccattaa 2001361 agaaagcagt ggagaaacga ttaataccat gccatcaagc atataaccag gcagctggta 2001421 gcaaagcgat ttccctcccc cagtcgggag cattgcaatg gtatccttcc cgctgagtat 2001481 gctttcaata atgtcctgct gccctttttt aaaggaagta aaaccaaaaa actgatataa 2001541 cgtttgctgt aatttagtca tattgctgca cctgctttgt caatgccagt ctgatttgaa 2001601 agtagctgaa ccgctgttcc agcccgtcgc gaatttgttt gattttattc gtccgcatcc 2001661 gtttggcaaa ctctgcgatt tgaagctggt cttctgctga tacatagtca ttaatcataa 2001721 acgcaggctc atggagagaa atctcgacaa tgtggtcttc aatcgtcgct gttttcagct 2001781 ttctgatttc agcaattcgc tgtatcggaa acccttgttt gaccatctgc catgttttcc 2001841 tcgtcgactc tgtcagggca ttatctaagt gcacatcaga aaggagatcc tttaacaaag 2001901 catcttcaca ctccggaaga gaatgaataa aataatgtac cgaagcccaa aacatgatat 2001961 agacatacca ttcgtcttct ttcagcgtat cagcaagctg cctgctcgta taaccgatcc 2002021 gatggtgcga ggttaaggag tagacaaaaa tttgcgctgc tttgttttca atctttttca 2002081 aatgcgcctc aagcatggca aaaaggcttt ttgccatctc tatatgatcc gtatgccggg 2002141 acaggtattt ctttacccag tgaagtgtct tatgatcctt tgtgacaggg atatactgcc 2002201 tgctcccttg ctgtttatgg gataggacct gcacaagcag cgaaagcctt ttccaaagca 2002261 cgccggcagc ctgctgataa tgagcgccgt gacaatgaac gggccaaggc cgctcgctaa 2002321 gggcatgtct caaaactgct gcgccgctgg ctgtcacttt gtatgtatct gattcagaca 2002381 ttggcgcgag atatgaatgc ttttcaagct tgtcaagcga cgcagaaata tcgcttctcg 2002441 aacattttgc cgccattcca aagtattttg cagtctgaaa taagccggca tcttgaatgg 2002501 tctgtgacga tctcttgcct ttgaataggt gaaaaacagc gcttcccgac cgttccccgt 2002561 ttattttgca aagacaatcg agaaccataa tatcgaagta atttaatgac aacctatcca 2002621 cctacattct tcctgacaaa aatcgttgat ttgctctttt tattttaaca gatttcaaac 2002681 agaaatcgac gtttaaagtc atcattaagg gggatgttat gtagataacc ccttatgtga 2002741 taagcattct caatcatttt tctgttgaaa tgtggcagca acatcattac aataagtaag 2002801 aggaataggt gttaaattga ttaaatataa agattgatcc atttgttcca ccaagaacaa 2002861 tctgggaggt tttattcatg gcaaagtaca caatcgtaga caaagataca tgtattgcat 2002921 gcggcgcttg cggagctgct gcaccagaca tttacgatta cgatgatgaa ggcatcgcgt 2002981 tcgtaacgct tgatgaaaac aaaggtgttg tcgaagttcc tgaggtactg gaagaagata 2003041 tgattgacgc atttgaagga tgccctactg attccatcaa agtggcggat gagccatttg 2003101 aaggcgaccc gcttaaattt gaatagaagt aactaaaaaa agctcccgaa cgggagcttt 2003161 tttatttaat ggatatgtgc acttcgctgc tgctcaatcc atggcttaag cttgataaaa 2003221 attagtgaga atacaaccgt aattacaata ccttttatca tgttaaacgg caggatacct 2003281 gcgacgactg ctgtttttag cgcgctgtcg gataatgccg gtgaatgtaa aaaccacgtg 2003341 tatgccggaa gaatcagaac ataatttaaa atactcatta aaatggtcat cgctgcagtt 2003401 cccaaaagca ggctgacagc caagcccttt gctgagttga gttttttaaa taagaaagca 2003461 gtcggtaata taaagagtgt tcctgcaata aaattcgcaa cttgccctac aggaactccg 2003521 gccatgcttc cctgaatgat atactgaaga acatttttta tcgcttctac ggcaataccc 2003581 gccaaaggtc cgtaaatcag aatggcaata attgcgggaa cgtcgctaaa atcgattttt 2003641 aaataatccg gaagacccgg aaacgggaaa tttaacagca tcaaaacaaa tgcaatgctg 2003701 ctcagcatgc tgaccacaac taattttttt actttcactt cattctctcc ttttcgatca 2003761 catcttactc gaaaacggaa aggttctttt ccagccaata aaaaaaccgc ttcatatata 2003821 aaagcggggt ttcgaaaatt aggctaggca aagaaacgtt tgaaaaattc aatttcaaaa 2003881 cgcttatgaa cctccatctt ctcccatcca gactgtactg tcggctccgg aatctcaccg 2003941 aatcctgctg taaagacagc tcgcgggctt agagccattg gctcatcacc gccggtaggg 2004001 aatttcaccc tgccccgaag attgatcata tgaaatttaa ttacattata aacgataact 2004061 ggttggctgt atagagaatt gcttcaaatt aaatatatta cctgcaagct gtcagatcat 2004121 tgatttatta ggctttactt ttatccttta ctgcgtcaat acacgttgac actcttttga 2004181 gaatatgtta aattatcaga tatttagttt gtcaatttag gaggaaatct aacgatgttt 2004241 cgagtattgg tctcagacaa aatgagcaac gacggtttac agccacttat tgaatcagac 2004301 tttattgaaa tcgttcaaaa aaacgtagca gatgcagaag atgaattaca tacttttgat 2004361 gctcttttgg tgcgaagcgc gacaaaagta acagaagacc ttttcaacaa aatgacttct 2004421 ttaaaaattg tcggaagagc cggtgtcggt gtcgataata tcgatattga tgaggctacg 2004481 aaacacgggg taatcgtgat caatgctccg aacggcaaca ccatttcgac agctgagcat 2004541 acatttgcaa tgatctcttc tttaatgaga cacattccgc aggctaatat ctcagtgaaa 2004601 tccagagagt ggaaccgcac agcttatgtc ggttcagagc tttatggaaa aacgcttggt 2004661 attgtaggat taggccgaat cggaagtgaa attgcacagc gtgcgagagc gttcggtatg 2004721 actgtgcacg tttttgatcc tttcttaacg gaagaaagag cgaaaaaaat cggcgtaaac 2004781 agccgtacat ttgaagaagt gcttgaaagt gcggatatca ttaccgttca cacgccttta 2004841 acaaaagaaa caaaaggctt attgaataaa gaaacgattg caaaaacgaa aaaaggcgtt 2004901 cgcttaatta actgtgcgcg aggcggaatt atcgatgaag cagcacttct cgaagctttg 2004961 gaaaacgggc atgttgcggg agcagcgctt gacgttttcg aagtcgaacc gccagttgac 2005021 aacaaacttg ttgatcatcc attagtcatt gccactcctc acttgggagc atcaacgaaa 2005081 gaagcacagc tcaatgtcgc cgcccaagtg tcagaagaag ttctgcagtt cgcaaaaggc 2005141 ctgcctgtca tgtcagctat caacctgcct gccatgacaa aagatgaatt tgctaaaatt 2005201 aagccttacc atcaaattgc aggaaaaatt ggcagccttg tatcacagtg catgaaagaa 2005261 ccagtacagg atgttgccat tcaatatgaa ggcacaattg ctaaacttga aacatcgttc 2005321 attacaaaag cccttctgtc aggcttttta aaaccgcgcg tagactctac tgttaatgag 2005381 gtcaatgccg ggggtgtcgc aaaagaacgc ggcattagct tcagtgaaaa aatttcctct 2005441 tctgaatctg gatacgataa ctgcatcagc gtaaaagtga caggagaccg cagcaccttt 2005501 actgtaacgg ctacgtatat tcctcatttc ggagaacgaa ttgtcgagat caatggattt 2005561 aatattgatt tttatccgac tggtcacttg gtgtatatcc agcatcaaga tacaacaggt 2005621 gtcatcggcc gagtaggacg tattctcgga gataatgata ttaacattgc aactatgcag 2005681 gttggccgta aggaaaaagg cggagaagcc atcatgatgc tttcctttga cagacatctg 2005741 gaagataaaa ttgtgaaaga actaacaaat gtccctgata ttgtgtctgt gaagctcatt 2005801 gatctgccat aattaaaaaa actcaagcta tatagcttga gtttttttat tgttctatcc 2005861 ccgtgtgttt ttatgcaaaa tatctaagac actccttagc tcagaaacag gaatttggcc 2005921 tggtgcggac gcctcttctc cagctccaaa agtacaagcc gatccaaaaa cctcaccgct 2005981 cagcctgctg atgagccctg ttgcagccat tgacattgta ataatggggc ggtctgcata 2006041 tattgttttc attgtatacg tcgcatcaag cagtgttagg agatctccag tatcattcgg 2006101 catgacagcc atttttggaa tatgcgcgcc taagtcctgc atttttcgaa gtctggaaat 2006161 aatttcatct tttacaggtg ttttttcaaa gtcgtgattt gacatcacca catagacgtt 2006221 gttttcttcc gccagcgata ctaacgcttt tacatttgca tctcctgaaa ataattcgat 2006281 gtctatcaga tcgatgtctt ttgtttggat tgccgattcc agcaaagcaa gataggagct 2006341 ttcgtccatc tccatgctcc cgccctcttt gtgggttctg aatgtaaata gaaatagctt 2006401 gtcttctaaa gatttacgaa gcttagaaat gagctttgtg accgcttctc tgtcattcgc 2006461 tttttcaaat acgtcgactc tccattcaac aatgtccgga ttcagtaatt ttactgcctc 2006521 tgcttcattc agaatttgtt tttccgtctt tcccatcagc ggaatgatga ttttcggcat 2006581 cccttccccg atggaaactc ctttaatcgt taacacgttc actcgtctca aatcctttca 2006641 atctttacct tgttttatta tacacgtaca actttttttt gaaaatttct attatatgaa 2006701 tagcaactaa aaaagagcct taaagggctc tttttagttt aaggaaatcg gatttggagc 2006761 agctggcacc ggaattgcat ctgatatgtc atatttgccg atttttttcg ttctggtttc 2006821 cgtaaaggtc acttctgtga agccaaactc ttttgcagtc aaaagtagtc cctcaatcat 2006881 taaaataccg gcaatagaat catcaacttc tgactccttt gaaaagcgga tatataagtg 2006941 tttctgtttc ttcgttacag attggacagc acccgcttga ataagaggtg tcgtatcttc 2007001 ttggctgctc gattccattt ccttaatcgc ttcttttact gtatcaaaag aatgatttga 2007061 cggaacgaga aagtcttgtc cttgtttatt ttggtacaag tagtaggatc gttttgactg 2007121 tttgggaatc gaaatttccg taaaagtgcc atatgagcca atccgaaccc cagtctcatt 2007181 ttgatccgat aaaaatttga ctttttcata aggactccat tttaaggatt ctttaagcaa 2007241 tttttttaac agtgtatcat cttttataga aaatgccgta gctggctgat ggactcgtat 2007301 acttaattcc ttctgctttg gtttttcctt tatttctact tcatctatga aggttggaat 2007361 tgtaatggca tgatcaagga tgcccaattc actactttca aacagcatat cctggatcgt 2007421 ttggtctgca tttgtttttt gaatgctgac gggtatgatt gcagatgtat cggcatcagc 2007481 aaccgctaca gtgatgtaat tgtcttgttc cttttcagga acgacaaacg atgtctgatc 2007541 caaggacgat gcagcttttg ggctgtcttc tgtctcagtt ttcgttactg cgttctcttg 2007601 ggacgcttct ttttgttgag gctgtgcctg atcaaagaaa tgaggagaaa taatgaaggc 2007661 gatataaacc gcaattgcag cggcacacgc ggggccaatc cacctgacag cgggcttatt 2007721 tttacgcttt gccatcgtca gccgcttgta aatatcctga ggcgaacgat ggtctttaac 2007781 tgccggaagt tgacttaaca actcctttat ctgttcttcg ttccattctg acttcatcat 2007841 ccattagctc ctccctcaaa agctccatat gtttccgaag tactttgagc cctctgtgtt 2007901 gggtcgtttt tactttgctt tccgagaagc gcagagcctt ggctgtttcc tgtattgaat 2007961 atccctgaat aaaccgcaag ataatcacag ctctttgatc gattgtacat tgatcaagcg 2008021 cagcataaat ttcccggaca ttttcatgtt gaaccgcaag ttcgtccggc agcaattgct 2008081 gatccctgac atcctgtgta tcccagtcaa atgtaccgag tatacgctgt ctgattgttt 2008141 gctgtttacg gaaccagtct atcgcaacat ggcgtgcgat agacaaaagc catgtttttt 2008201 cactgcttct tccttcaaac gtatgataag aatttaatac ccggatataa acctcttgaa 2008261 gaaggtcttc tgtctggttt ttatccttta ccatataaaa taaaaattgg tacaaatctt 2008321 gatgatatgt atcatataat aattgaaagg tttcttccat ttgaaacccc tccgttcact 2008381 tttttgtcgt atgaatagct tgaaaagtta cattacaact atattacgag taactggaat 2008441 ttggaaggga atttatatta acatatcctt aaattttatt aatgttggct attaaaaaaa 2008501 cacccgctca gtcagcgggt gtttcttatg gaacaagatt cttcggcaaa ttcagactcg 2008561 attttaccgt tttgtcggaa tataaaaaga aaatgttgtt cctttatcta ttcggctgtg 2008621 cacagtaatt gatccgttgt gggcttccac gatattttta acgatagcca gccctaaccc 2008681 ggttcctgct ctgccccttg tccgcgcttt atctgcctta taaaaccgct caaagataaa 2008741 tggcagatct tcttccggta tgccagaccc ggagtctttg atatcaattt tcaatccatc 2008801 cttcacagaa tggactgaaa tggagacact gccgccggct gaagtatgcc gcagcgcgtt 2008861 atcaatcaaa ttggtaaata cctgctccat cttgtcttca tcaaacataa attcctcttc 2008921 tgtgagagaa atgtcatgat ctaaagcaat atttttttct ttcgcaacac cggaaaactt 2008981 ccgaatgatc ttttctaaaa actcattcac attgattttt tcataatgta agcctgtatg 2009041 gcctgattcc attcgggcta aatcaagcaa atcattaact aaacggccca ttcggagcga 2009101 ttcgtcataa atgatttggg caatttcttt ccggtcttct tcagagcttg caatgtcatc 2009161 gacaattgct tcactgtatc cctgaagcat ggagatcggt gttctcagct catgactgac 2009221 atttgcgata aagtcctccc gcagcttatc aaggcggcgt tcttctgtca tgtcacgcag 2009281 tacggcaacc gctcctctga cgtgcgattc cgcataaagc ggcgacatca aaagcaccca 2009341 tgatctgcct tgaagcgtca tctcaatcat ttgttctttt tcagtgctga cagcgttttg 2009401 aaacagctct tttgcttcag gcggaagatt gtcgccttct ttgatattca tgttctgttc 2009461 ataataccaa gcctgaagaa aacgttcagc cggcgggttg gtcacaagaa tcgtaccgtc 2009521 aatattaatg gtaataaccc cgtcagccat actgctcaaa atgttagaaa gctgctcttt 2009581 ttcttgattg agcgcattga tatgaaagtt aagctgccgg cccatttgat taaaagcggt 2009641 cgccagttca ccgatttcat cctgagttaa aatcgggatt tttgtatcga acttgccctt 2009701 cgccaaatcc tgcgcgcctt ctctcatttt tcggagaggg tacgtgaccc tgcttgataa 2009761 aaagaatgcg aaaaatgtgg tcagcacaat cgcaattcca gcggcaagaa aaatatagcg 2009821 ggtcgtatgt tttgttgtat ctttaacggc aagcaaagac tgggataaaa agaccatgcc 2009881 tttctttccg tctttttcat acgggacacc tacaatcagg cgttcattat ccgtgtctgt 2009941 atcgctcagt cccgtccgtt tgcttacttt tttatggtct ttgagagctt tatttaagtc 2010001 tttgtcatgc tgtatttgct caaccgtaat agacgacagg cgatttttat cattcggaga 2010061 ataccagtgg ttcttctcat cctggatgat ggcaatgctt gttaagttat cagcgagttc 2010121 ccaagtgatt gaccttgcca gtgcctggtc ctcgtgattt tctaggatga cagcaacttt 2010181 attcgcaagc tgtgttaaat cattctcagc ttcttccaca tggtagtttt caataaactc 2010241 cagcaaaaga accgttaaaa tgaacaatac gatcaagacg agtgaaagga tcgtaaacca 2010301 cagcttgcct actacgcttt tccaaaattt cattcagcgc cgacctcaaa tttataacct 2010361 acaccccata cggtgacaat ttttttcgca gcttccggag ataccttgtt cagcttctct 2010421 ctcaagcgtt tgacgtgagt gtccactgtc cgtaaatcac caaaaaactc atattgccac 2010481 acttctttca gaagcttttc ccgatcatac accttgtcag gcgttttcgc taagaaatat 2010541 agaagctcat actcttttgg cgtcaggctc acttctgttc catcagctgt tacgcggtga 2010601 gcatcatggt ctattgacag atgtgaaaac acgagcacat ttttcgtcgg tgtattggca 2010661 ttgaaataag aggtttggga tgctcttctc aaaagggcct ttacacgcag cacgacttct 2010721 ctcgggctga acggcttaac aatataatca tctgttcccg cttcaaaccc ctgcacccgg 2010781 tttgcttctt ctccttttgc ggtcagcata ataatgggtg tcgctttttt ttcacgaatt 2010841 tgccggcaca cttcaattcc atcagtcccc ggcatcatca gatcaagcaa aattaagtca 2010901 taattggctt caagcccttt ggcaatggct tcatcaccat tttcagcttc atctatagca 2010961 taattttcac gttcaagata cattcttaaa aggcggcgaa ttctggcttc gtcatcaact 2011021 actaatattt ttgtttcgtt cgtttggtcc atgttttccc cctgctttcc ttctgttact 2011081 ttcattttat caaatcgtga gaaagtttga gaactgtgtc gctttcaaag gactatgcat 2011141 aagaatgaag tccggcaagc acaagattta cgaatattaa attaaacata ataatagcaa 2011201 aaccgattac ggccagccat gctgacttct caccgtgcca gcctcttgac agtcttaaat 2011261 gcaagtaagc ggcatagaac aaaaatgtga tcagcgccca tacttcctta gggtcccagc 2011321 cccaaaatct ggtccacgcg agctgagccc aaatcattgc aaagatcagc gcgccgagtg 2011381 taaagatcgg aaatccgatt gatacggccc tgtacccaac ctcatccacc agatcaagat 2011441 tgacgttttt caccagcgga tgtaatagag cgctgattct ttttctgatg atcagacgga 2011501 gagccccata caacacaaga cctgctccaa atgaccaaat gacagtgttc acttttctgc 2011561 ctgagaaaag cgcgggaaga tcaacaagcg gttccattct tccttcggtc aaaagctctc 2011621 cctgatgcgg accgacaagc gcgggcattt cgtacaccat cacgcttttt tctttacttt 2011681 tgtccaccca gttaaactcc gcttcatagc ctgcaagacg aaatgccgat gtgattgcaa 2011741 taaaggcgac ggttgtgacc aggataaaca taatcgcttc aagccagaag gtctttttgc 2011801 ttggctttgt ctggtctaca tgcttcaaaa gaaagatgac accagcgaca aagctgatgg 2011861 caagtatagc ttgcccaagc gcggccgttg ttacgtgaat atacagccag ttactttgga 2011921 gcgaaggaat taaaggcgag atatctgtcg gaaacatgct ggcgtaggca atcagcaata 2011981 aagcaattga cagcgtaaac aggcctaatg aaggcaatct atagagaaaa taaagaatga 2012041 taaacgccaa aacaagcatc atgccaaaag cggtggtgaa ttcaaacata ttgctgacag 2012101 gcgcatggcc gcttgcagcc caccttgtga tgaaatatcc taggtggcag aaaaaaccga 2012161 caatagaaag ggtgattcca atgttggccc atcggtttgg cctgcccttt ttatctttat 2012221 tcccgcgtat ggccccgccg aagattggga cagcgattaa atacacaaga aaggccgcat 2012281 aaagaaaatt tccgctcagc tctgccatga catcactccc ttttcgccta tttctgtgtt 2012341 ttgattaatt ctttttggtc caccggttca gtcagtccgg aatcagccaa tataaatgct 2012401 aaatccttct tcaggccaaa ccagttttta ttggtatgcc ctgctaccat aactgcaccg 2012461 tcctgtgagt gcagccaaat tcttcgatgc tgccagtaca taccttgaat gacaccgatc 2012521 ataaaaatgg ctccgccgac agcaagcacc cagagtgtca gatcctttct gactgtaagt 2012581 ccagtaatgt ttttcgtttc gacatggtca aatttcagct tgtatttatt attgcctgat 2012641 ccttcgatgg tttcttggat ggcgacaaag ctcttttcgc ctttcggttt gtccggcgtt 2012701 atgatattaa agacaaaagc cggattgtta gggatctttg tttttgtgct cggctctccg 2012761 tcctgattaa aatagaagtc aggcaggtag ctggcgattt ccaccttgta accgttacca 2012821 agatcataga ctgaatctgg atccagaagg ttgatcttca ggctcccaaa ggattttttt 2012881 gtttttttat caatcagctg gaacaccatt tggtcaagct gattctcttt gtaatccacc 2012941 tggtaaacgg aaaaagaatc aaaacgcagc ggctgattga cacggatgtc ttcttctgtt 2013001 actttttcca gcttcggctt ctcgccataa acaatttttc cttctctctt gtagagtacg 2013061 gcatcagttt gaaagttctt tgccactcta ccgtccccga ctctgtcaat ggcatctgca 2013121 aatacctttt tttccgtttt gctgttatag gtctctacgc tgaattgatt gtttttcaaa 2013181 taatattttc cgtctgtacc cggaattgct gcggtttcgc cttctctgac ccaaagcgtc 2013241 tcatcgacgt acatgccagg cacaaatctc agcatcgcac caatcagaaa gatgatcaat 2013301 ccaatgtggt tgacatacgg gccccagcgg gaaaagcgtc ctttttcagc aagaatgctg 2013361 ccctcttttt ctctgattct ataatgtttt ttctttaata gagtaactat cttttctttc 2013421 gattccccgt tcagtacagt aactgtttca ctgaacaagc gctgccttct taaaaaggcc 2013481 gggctccttc tgacaccttg gttttttaac gctctataca acggaatgac ccgatcaagg 2013541 ctgcaaatca cgagtgaaat gccgatcgag gcaatgagca gcaaatacca ccaagaacca 2013601 tataaatgat gaaacccgag caaataataa agctggccaa acgtgccgta ctgctccttg 2013661 taataagtat cagcctgtgc gcccggaggc agataggctt cctggggaaa aatggtgccg 2013721 aacgctgatg cggcaagggt tatgacgata agccatattc ccaccttaac cgaggaaaag 2013781 aaattccaaa ttttgtcgat gatcgttttg ttataggttt gcgaacgtct tgcgcttccg 2013841 tcatatctca tatcagcgag cggaggttga gtttcctgaa gagctcttcc gcacgattcg 2013901 cataaaacgg ttccgaccgg gtttatatgt ccgcattcac atttgacttg cttcatcccg 2013961 aagtctctcc gggttttatg agattcatat aatcgtgtat catgctttct gtcatagtgc 2014021 cggtcaccac cttgacaact tttccttccg gattgatcaa aaaggttgtc ggaagcggag 2014081 atacgtcata ggcatcaagc acttggcgat ctgtatccag aacaaccggg aaattgactc 2014141 cgtaggattt cataaaatta tgtactgcta tctttgactc cccaacattt acagcgacaa 2014201 tttcaacacc ttggctttta aaatgcttat attggtttgc catataagga aactcttttt 2014261 tgcacggttc acaccatgta ccccagaaat tcaaaaaaac acctttccct tttaagtcac 2014321 tgagctcgat acgtttccca ttcgtatcct ctaggacaaa attcggtgcg tcggaccctt 2014381 cggatatact ctctttgccg gcaaatacag cgttgtaaat ggtatagccg agtgcgcaga 2014441 ttaaaacgag aaggatgccg gtccgaatga ataaacgcct ttttttcttc attgtccact 2014501 gcccccttcc ccctattgca gatccattca attatatcat tgcacgttca tttcacattt 2014561 cttacttttt gaaggttatg tgaaatttag aaagcgtttt taccgtgatc cgccagtgct 2014621 ctgagccttt ttacttcgtg aggcgtaagc tctctggcat cgcccgtgtg caggcctcgc 2014681 aggtttaaaa acgcgtattc ctcacgcttc agcttgatta cctcatgtcc gatcgcttca 2014741 aacatgcggc gcacttgtct gttgcgtccc tcatggatcg tcagctgaat aatgcttgtc 2014801 tgctttttct tatccaaaga cagcagcttc gctttagcag gcgctgtttt gccttcctcc 2014861 agcctaattc cgcgctccag ctttctgagc agctctttag gcgggattcc tttcaccttc 2014921 gccacgtatg ttttgtctat ttcatactta ggatgcatta gcttattggc gaattcgccg 2014981 tcattggtta aaagcaaaag accgctcgta tcatagtcca gacgcccaat cggataaatg 2015041 cgctgcggaa tatttttaaa aaagtccgtc accactttgc gtcctttatc atcttgcgct 2015101 gcggaaataa cgcctcttgg tttatataag agaaagtaaa ccggctcttc gcgttcaacc 2015161 tttaacccgt ttacctcaat ctgatcagaa ccggtgacct taacacctag ctctgttact 2015221 actttgccat tcacctttac ttttccttct ttaatcagct cttctgcctt tctgcgcgac 2015281 gcaactccgg catgagcaat cactttttgc agtctttcca tgtctttcac ctcaagtatt 2015341 atcttacttt tttcaacctt aacaaacaag ctttttcaaa ttcctatgcc aaatctaaaa 2015401 aaaacgccgt tttcaggcgc tcccaaataa taacgtaacg atgatgatag atgcaactac 2015461 gccgattaaa tctgcaagaa gtcccacctt taatgcatca cccatttttt taatgccgac 2015521 tgctccgaaa tacacagtca gtacgtaaag cgttgtatct gtagatccct gcatgacgga 2015581 agccagcctg ccgataaagg aatcgggccc gtatactgca attaaatcgg tcgtcattcc 2015641 aagtgcggcc gtaccggaga tcgggcggat cagagcaagc ggcactactt cagcagggat 2015701 gccgatagcg gagaaagccg gttttaaaag atccattata aaatcaagcg cgcctgatga 2015761 tctgaaaaca gttatagcga caagcattcc gactaaatag gggataatgg aaaaggcaat 2015821 ttctatcccc tctttcccgc cttcgacaaa cgattcatat gtcggaacct ttttgatcgt 2015881 tccataaaga agaattccgg caataatgat tggaatcatg gctaaagaca gccagttgat 2015941 gatttccatc cgctcacctt cccttctttt tgcggcggta ataaaaatac cgatcaatga 2016001 taatggcacc gattccggaa ataagcgttg ccaaaatgct tggcccgacg atatctgtcg 2016061 gcgttttgga ggaataagcc attcggacag cgatcaccgt tgtcgggatg agtgtgatgc 2016121 aggacgtatt aacagctaaa aaagtaatca tcgaccggct tgcttccgat cggtttccgt 2016181 tcagcttttt catttgttcc attgctttaa tgccaagcgg agttgctgca tttccgaggc 2016241 cgaagaaatt cgccataaga ttagataaaa tatagcccat cgccgggtga tccggcggta 2016301 tatcagggaa cagtttagat ataaaaggtc tgcacatccg gctgaaaata tccaaaagcc 2016361 ctgactgctc ggcgattttc attaagccaa gccagaaaac aagcacgctc atcaatccaa 2016421 atgagatcgt aatcgcttct ttcgcaccct taaacacggc ttcatttaca tcttgcagag 2016481 ttccgttgca catcgcaaaa acgagtccga tcacggttaa actgacccaa attatattga 2016541 ccattttgct ccgcctgccg cattcagaaa gattgattta aacgtttcaa aaaattgttt 2016601 cttcggtttt tgatgccgct cattttcata atagatcggc acttttgcga tggttgcatc 2016661 gttgaacatg atctccatgt gccctacgat gtcagggatt ttcgaggcat ctttttccca 2016721 tgcttttttc ggcttgagca gtgtggtatt aatttttaca ttttcttttt cctcttcggt 2016781 cagcaaatag gtgatatcac gtttgataaa agccttcgat tcataaaatg tgcctttcag 2016841 ctttggaata tccccttttt ttgcaattaa ataggtttga taatgctcaa acacatagtt 2016901 aaacatcttc atatggtcat cccaatcatt agggtcatta atggtgacgg ctatcaggtc 2016961 aatgccgtcc tttgaagccg tagagaccag tgtccgtttt gcaagttttg tatagcctgt 2017021 ttttcctcct gtgctgtacg gataaagcat ggtcagcagt ttgtttttgt ttttccatac 2017081 gctttccatc gtttccgctt tgtatatttt tgtgcctgaa atcttttgat agtctttcag 2017141 cttcatagca tacttagtta aaatggccat gtcataggct gttgaataat gattttcatg 2017201 gtcgtccaat ccgtgcgggt tttgaaaacg ggtgtttttc ataccaagct gctcggcttt 2017261 ttgattcatc atataaacaa acccatcgag gctcccaccg acatgctcag caatcgcgac 2017321 agcggcatcg tttcctgatc ttagcatcag gccatacaca agatctttca gcttcacttt 2017381 ttgaccttct gttaaataaa tggcggagcc ttctgttctg acagcatttg ccgaaaccgt 2017441 cactgtttga tccattttgc cggattcgat ggcgaggacg gcggtcataa tttttgtgat 2017501 gctcgcgatc cgcctttttt gatgctcatc cttggcatat aacactctgc ctgacgcacc 2017561 gtcaataatg atcgcgcttt ttgcactgac atctatagca gcatgtgctg tattcacatt 2017621 tacggttgca ataagaaaag aaatcatgat cacgaatact gcttttttga aaatgcgcat 2017681 gtttgctcac gtccttgtgg tggtttgtac aagtttatgc gcatgtccat cagttatgaa 2017741 taacaattat atttctggaa gcaaacataa aaaaactctc cctgaaaaag ggagagtaaa 2017801 cgttatctga ttggcgccat gcttgatccg gacgcttcgt aatgagccag ctcttccctc 2017861 atcttcagaa aggccgcgct caacggcaat aataattgct caagcgacgc aggaacagca 2017921 tgataaaact caattgcgct gaccccggta taagacgccc ggctattttc acaccacgtg 2017981 tcttttttcg gcataaagaa ctcttcaatg cattggtgat acacattata aagtgttttt 2018041 tccgctctgg cttcctgaaa aggctcctgc atcaggagac gacggcacgc ttctgcgcct 2018101 ccttcacaaa atactgccat tcttctcaga gtgctaagca catcacagca gtatcctttt 2018161 tcaataggca attcagcctg taaggactca agcgtcgttt gatttaggta atcgttcacg 2018221 gtattgacaa ccattgataa gaattcgcct gttttttgag tctgcgctcg cacaatcgaa 2018281 tgtcccattt cgtttggtat cttcccctca tgtatttgtc tctcacattt tgcttctttc 2018341 atgatagctt cttccttata tcttatgatg atgaaaaagc gcgattcatt aaacttctat 2018401 tttatatctt cgaaggtttg gttaaagttt tcaaaaaata aatctgcttc ttcttgaaga 2018461 acgtcttctt ccgcattttc aggcagcggc ggaagctcgt ccagcgtttt cagaccgaat 2018521 tgttcaagaa aagtcggcgt agtaccgtat aaaatggccc gccccggacc atcggcacgc 2018581 cctacttcac acaatagcgc cttcgcgaca agactgtgta aaatccgctc tgattttact 2018641 cctctgattt cttcaatttc tgctctcgta attggctgtt tgtatgaaac aatggccagt 2018701 acttctaaag atgcttgaga aaggcccttt gacggcactt caatcagttt tttcaagtaa 2018761 ggcgcaaagt cttttttggt agagagcatg tacgtatctg catactcaat aagttcaatc 2018821 cctcgtgtat ctccgcggta ttcgtccgcc acatccgcca tgatcgtgtt cagttcaggc 2018881 tcttcgattt caagcactgt taacagctgc ttttttgtaa gcccttcatc gcctgccgca 2018941 taaagaaggg cttccacaat agctttccaa ttcacgatat caagccccat gaatggattc 2019001 actccccgta atgtaaatat ctgaaaaatt gtgctcctgt tcaatgagga ccagctgatt 2019061 tttcatcagc tcaagaacag ctagaaaggt cactactaaa tgttcttttt gctcatatgg 2019121 aaacagatcc ataaagttaa ttctcgttcc tctagatttc aagctgtgca cgatttcgtt 2019181 cattctggct tcgattggta tgtcctgtct tgtaattgtt gtttccatcg gcctgtttat 2019241 ttttttgcgt ttcagcactt tttgaaaagc tccgatcata tcatagaccg tgacagagag 2019301 cttttgctca gactgtttta cttcttttgc atattcactc aaatcactcg gcggtttcgt 2019361 gaacgatttt tgtctttctt cttcccgttc ttttaaatcc ttcgccgcat ctttatattt 2019421 tcggtactca atcagctttt caatcagttc ctcccgcgga tcttcttctt caagtaattc 2019481 atcttcaaaa agctcctcct cttgcttcgg gagcagcatt ctgcttttaa tgctgagcag 2019541 cgtggcagcc ataaccaaat actcgctggc aatgtcgagc tcaagcacgc gcatcgtatg 2019601 tacatataat aaatattgtt cagtgatctt cgccacaggt atatcatata tgtcaatttc 2019661 aagacgattg attaaatgaa gcagcaggtc caatgggccc tcaaacgtat caattttcac 2019721 ttgatattct tccatcatct caccattttc aagtatcact ctcattgccg gaaaaactgg 2019781 ctaccctata gtataagcca ccaaaaagct ctcgtccaat actatttcat atcctgtttt 2019841 gaaggagttt gtacagaata ttcaaaacac aagaggtgtt tgctcggagc gcagaagcgg 2019901 gagaaaaagc ctttgcttct ggttttcctt tctaagaagc actagaggcc gggcgttctt 2019961 ttttcctttt atcccttcta tggtacacta aaagcacatt aaaggaggaa gcaccttgta 2020021 tccgaaagct tatatagatt atctcgttga gtttcatgcg acacgggatt attttgaatg 2020081 ccatgaaata ttagaagaat attggaagga agatccgcca aagaaacgaa aacgctattg 2020141 ggtgggcttt attcagcttg cagtggcttt atatcatcac agaaggcaga atacagccgg 2020201 ggcaaaaaga ctgatggcga acagcatccg gattcttcaa gcagaacacc gggcagtcga 2020261 agacttaggg cttgatcatg gccgtttgct cgaacttatg caatcggttt acgaacaaat 2020321 cgaaaccgtc tctgcctata aaagcattat actgccaatc aaagatgaga aactggagga 2020381 agcatgcagg atcgaatgca ggaaaaaaaa gtatacatgg gggcagccca gtgcactcag 2020441 caacatattt cttatcgaca aacaccgttt gcgggatcgg actgacgtca tccgtgaacg 2020501 tgaaaaagaa atagaacgca gaaaaaaaag cagagactga tcacagcctc tgcttaatta 2020561 ttgtatgaaa tgtcttgatc ctgctgacct tgacaacgtt cgaaaaagct ctgcgttaat 2020621 tcatttggaa ccagtacttg cgttttgaat aaatgcttta aagcatccat catctgtttt 2020681 ccgattcctt gatggcgatg agaaggattc acactgatat gccggatctc aacctcagaa 2020741 tccttttttt cgactccgat tgctccgacg atatcctcgt cctctttcca aagaaagagc 2020801 tggcggtctg tatccgtttc gtagtcctta attgtctgct gaagctgctt aaggtctttt 2020861 tcattcggca taaacgaaag aagccccatc gcaatctttt caaacgattt tttataacga 2020921 attaacataa aaacccctct atatccaaaa tgtccagtct gctattaacg gatacgaata 2020981 ggtgatccgt tttctcacat tatatcattt tcgccatatt tttaaactgt tttcagcaaa 2021041 ttattcaaat gagcggttta aatttgccat ttcaatggca gaaacagcac aatctacacc 2021101 tttgttgccc gcttttgtgc cggcacgctc gatagcctgt tcgatgtttt cagttgttac 2021161 aattccaaag atgacaggta caccagtagt gtttgctgct tgcgcgatgc cttttgcagc 2021221 ttcattgcag acataatcgt aatgtgtcgt tgcgcctctg atgacagtgc ccaatgtgat 2021281 aatagcatca tatttttttg tttccgccat ttttttcgca gcaaacggta tttcaaatgc 2021341 gcctggaacc caagccacat caatgtcatt tgtgtctacg ccatgtctga gcagcgcatc 2021401 ttctgctccg ctcagcagct tgctcgtaat aaaatcatta aatcttccta ctacgattcc 2021461 gattttaaga cctgtaccaa ctaaatttcc ttgtatgata ttcatatgat tcccatcctt 2021521 ttttgtgata tttgtgatta gaaatgaagt aaatgaccta gcttgttcat tttggtttgc 2021581 aaatattttt tattgtgttc tttcgcctcc atttgaagcg gcactctttc tgaaatactg 2021641 agtccgtagc cttcaaggcc tgcgattttt cgcggattat tcgtcaaaag cttcatattc 2021701 cggacaccga ggtcgcgtaa aatttgtgct ccgatgccat agttgcgaag atccggcaag 2021761 aatccaagcg cctcattggc ttctacggtg tcatagcctt gttcctgaag cttataagct 2021821 tttaatttat tgattaaacc gatgcctcgt ccttcttggc gcaagtacag gagcactcca 2021881 cggccttctg cggcaatttg gttcagcgcg gcgtgcagct gcggtccgca atcacagcga 2021941 tgagagccaa acacgtcacc tgtgagacat tctgaatgca cccggaccaa taccggttct 2022001 tctccgaacg gcacatctcc catcacaaat gcgacatgct cttttccatc tacctcattt 2022061 gtgtatccat aaaccttaaa tgtcccaaaa tcagtaggca gcgtaatgtc aacttcacgc 2022121 tcgacaagtg ttgtcagatt gtaacggtat tgaatcaaat ccttaatggt gatcattttt 2022181 aattgatgct ttttcgcaat ttcaatgagc tcaggcactc tcgccatcgt tccgtcttca 2022241 ttcataattt cacaaatgac gccggctcct ggagatccgc aagcttcagc aagatcaaca 2022301 gcagcttctg tatggcccgc tcttttcagg acacctcctt ttttcgcaat cagtggaaaa 2022361 atgtgccccg gacgctgaaa atcagatggc acggatttgc tgtccagcaa tgcttgaacg 2022421 gtaaaagatc tttcttgagc gctgatacct gtcttcgttt cacgatggtc tatgcttacg 2022481 gtaaatgcag tgtggtgaga gtctgtatta tgctcaacca tagggtgaag atcaagcctg 2022541 tctgcgattt cctcactgag cggcgtgcag atcagtcctc tcccatgtgt cgccataaag 2022601 ttaatgactt ccggcgttgc atgctcggca agagccacaa agtctccttc attttctctg 2022661 tcttcatcat ctacaacgat gatgacttcg ccttttttta aagcgtccag tgcttcttct 2022721 atcggatgaa acatgcaaat cttcctctct aaaagccgtt ttcgcttaag aaggcttttg 2022781 taatggtttg ttgggtctta ttttcattgg ctttatgcaa aaatcgatac atatattttc 2022841 cgatcatatc gcattcgata ttcactttag agccgatcgt tttttctgaa aagatcgttt 2022901 cgctgatcgt atgcggtatt aaggagatcg tcactgtgtc ttctgtcagg ccgaatatgg 2022961 ttaagctcac gccatccaca gtaattgatc cctttaaaac caatgttttt gttaatgacg 2023021 ggtccatttt taaatcatag taaactgcgt tgcttttctc ttcaattcgt gtgatttccg 2023081 cagttccgtc gacatggcct gagacgaaat ggcctccgaa acggccgttt gccgccatcg 2023141 ctctttccag atttactttg cttccttttg ttaaatcatt cagtgacgta gctttgactg 2023201 tttcaggcat aacatccact gtgaattgat tttttgtaaa atcagtgaca gtcagacaaa 2023261 tgccgttcac tgcaatgctg tcgccaagat gaacatcctc taaaatcttt gagcatttaa 2023321 tagttaaggc cattgcatgc cctgcttttt tcatggattc gattgtgcct gtttcttcga 2023381 taattcctgt aaacatggtc accatcctat tcctttgtcg gttttgccgt cagtttgata 2023441 tcacggccga tttgggttat atcagtgaat tgtaataagg ggacatcttt cattgattga 2023501 aaaccttcac cggagattaa gctgggagca tgcgttcctc cgattagttt aggggcaaaa 2023561 tagaagatga tttcttgaaa acagccttct ttgacaaagc ttccgtgaac agctgaaccg 2023621 ccttccacat acaccgacat gatgccttct tccgctagga tcttcaaaac atcaggaatt 2023681 tgaatgcgct cggtttcaag tgtaaatatg ttcactccga aagctgaaag ccgttttttc 2023741 ttttcctcgt ctgcgcgtgc cgtcgtaaaa atccatgtcg gcgctatttg atcgcaaatc 2023801 actttagcgt cctcaggaat cgagagtacg gtatcaagta tgacccgaac cggctgtttt 2023861 gttacattcg gcagtctgca ggttaagctc ggattgtcgg ctttcactgt gccaactccg 2023921 actaaaatgc tttggtgtgt tttcctgtat tgctgagcat cctgtcttgc agcctctgac 2023981 gtgatccatt tgctgtcacc cgtgctggta gctatcttgc cgtcaaggct ggcagccgct 2024041 tttagcgtga cgtacggaag gcctgtcctc ataaagtgca gaaatttttc attcagcctc 2024101 tccgcctggt ctgccaggat gccttccctt acctcaatgc cagcttcttt catcatgctg 2024161 atccctcttc cagccacaag cggattagga tctctcatcg ccacgaacac tcttttgata 2024221 ccagagttga taatcaattc tgcacatggc ggtgtttttc cgtaatggct gcacggttcg 2024281 agtgtaacgt aaatgtcggc accctctgca tgtgctccag ccatatggat ggcatgaact 2024341 tctgcatgag cttcaccata ttttaaatgg gcgcccattc cgacaatttg tccgtccttt 2024401 acgacaacag cgccgacgag cggattggat tcggtctgtc cttcgccctg cttcgcaaga 2024461 tctaaggcca gcttcatata atactcttcc atttgtttcc ctcccctctt ttgttattta 2024521 ccgtcaaaaa agccccgaat ttataaaaaa ttcggggctt taggtatttt acgcaatagg 2024581 aaataacact atgcattttt aaacattttg catagcggct catcatcctt ctcccatcca 2024641 gactttcact gtcggcttca gcttaaactg aatccaccgc gtgcttatgc acacgggtca 2024701 cgggctctaa agcaaatgtg ctttactacc gccggtcggg atttccaccc tgccccgaag 2024761 gatacaatct ttattcattt gtccttattg gttattatag cgatcctttt taaagtacgc 2024821 aatgaaataa acttacaatt tgagaaaaac aaaacatcac ccttcgatcc gaaaggtgat 2024881 gttttttaat cattcacttt tgcaaccttg attaatccgt cgatccgctt tgatttgctg 2024941 aagtaagcct taatcttgtc accttctttt atatcagata aatcctgatt taattttttt 2025001 ccgttgaaga tgattttcgt tccgttttct gctactccat gatactctga gccgtcaatt 2025061 ttcgtcactt tatattcctg gatggtgtat tcctcttctt ccgaggacaa ggtttgtcca 2025121 attgctgtcg gaacatcctt cagctcaata tcatttatgt acatataacc gcctgcaagt 2025181 aaaagcaaaa gcactaacag aatggtaatc ttggttttta ttcttcccat ttctaaacct 2025241 ccagccaata tgaatctatt cattcatatg agttattcct ttttttcatg aataaaaaac 2025301 cgtaaattct cgtaaattat taatataacg atgcataacg ggaatatgtt tcacatttct 2025361 gcaaaaattt cttttctata gatatacgaa tttatgttct gtttttaggg gatgaccgta 2025421 aaaaagatat aaaaaaagca gccccaatgg gaagctgctt gatcctaatt tgttttgcgc 2025481 atttcgttaa acgggtagaa aacaaacttt gacgtacccg caatttgttt tttcgtgaag 2025541 aggccaaggc cgttacggct gtccatggaa ttgcgacgat tgtcacccat cacaaaatac 2025601 ttgttatcag gcactttaac cgggccgaaa tcatcggtca aatggtcaaa accgtcctgt 2025661 ttcgctctct ttttattagc cgccaaataa ggttcgtcca cctttttccc gttgatatag 2025721 agctggtcat ttttcatctc aaccgtatcg ccgggaaggc cgataatacg tttgacatag 2025781 tgaacatcat ctccgtttaa cacgacgatg tctcctctat caaactcgcc gatgtatttg 2025841 actgtcatat taacaaaaac cctttcacgg ttgtgaagtg taggatacat agagtcacca 2025901 tcaacgacat acggcgcaaa aataaagttg cggatgagca aagcaagaac gacagcaatc 2025961 acaattgctt ttgcccattc taatattgac tttttcttcg aaacattttc tgatttcaac 2026021 tgatttcctc caataaacaa cggtcttcaa tttatgttat cacgaatcga aaaaaaatcc 2026081 cattaggacc attgaagtga ttttacaaac tgttaatctt catcttctac ccacatcatg 2026141 cctatttttt cttgtcgatc ataactaggc ctgaaaatat tgaaagaaat gaatcgcata 2026201 attcagaagc gatggactca gaagaaagag agttctcata tgcaaaatct ttagatcgta 2026261 tataaagcat gaggttacgg gcagtttgtt catttactgc attccattga tctcccagtc 2026321 catgataccc atggcacttg acaaaacaat taacgtcatg aaggttactg gaatgtttgc 2026381 ggcaacctat ttcacaggtg ataaccgcac cccgtttttt gctttcataa tatgtttaaa 2026441 atcattcaag ctcgaaaaca tggatcagcc tccaaaaaat aaatccaata tattcccggc 2026501 agttgaagac tctttattat aaaactctga atatccgcag ttcttacagt aaaccactag 2026561 aaatcggtta tgctgcacgt caaacagctt tgataatccc gtgccggttg tagctatttc 2026621 tttttgtccg gcttcagtac taccgcattt tatacagcct ttgttgttca tatcgcgatc 2026681 tccttttcat tacatcacgt ttgtttgatt tattttacta caaaatatca atcccaatga 2026741 cccgtactac tttaaagttt acttaatttt gattacatac taattgggtt cgtttctcag 2026801 cttggtaaat cttctggaga aacggaaaag ctccatgacc aaaacattca aactcagcca 2026861 aacaccgccg aaggcgtaac ccgcagcaac atcactcgga tactgctcat aaagtacaca 2026921 cggctcagcc cgatgaggaa taaaacgata ataaacaaaa aaatgcaaca gtttgcagac 2026981 gcgtcttgtg agaatgacga acaaaaagat aagcacaaaa accaaaaatg acaaatgccg 2027041 ttaaagtctg ttcgctcggg aatggatata atacatgact ttccaaagga gcgtgaacag 2027101 gatgaaggga atgaaagagc cgtctgattc cctcttcata aagctcccca ccaatgacta 2027161 ggaaaaataa gaaagagagt tcgattttcc gatcttgccc tctgaatacc gtccaaaaaa 2027221 aagttagaac aataacggct aacagaacac ctctcgacgc aaaagctttc tgaattgcag 2027281 ctgggcccag tctatacccg atccaatacg acatgctcac tcccacagct ccccaatccg 2027341 gccgctaaca tgcttagcac ccagtttaac ttttcttgaa acacgagaac accggcaaac 2027401 tctcccggtc caagtaaagc tagaagctct aacatcaaga caataaacaa gacggcatat 2027461 ccgtactgtt cgagcaaccc cgtcaaaact tgcatgtgat tctccttaaa cttttttgtt 2027521 cttttatcat tcccaatcca ctttttgtat aatcagcaca attttatctt cagtcgtcca 2027581 acaacattgt ctatggcggg atcttctctc atacattctt ttttgacata ggaggagcaa 2027641 tagcatgaaa tgggaggaaa caaaagatac gcagggagtt tgccaaaatt ttgggcagtt 2027701 cgttctgcca ccgagtcagg tgtttgtttg cccacctcat cccttgtcaa ttccccattt 2027761 ttcccgtttg aggttcgaaa tggtaaagta tttcacttag tttcttacat gaagaggtaa 2027821 attctttgct caccgaacta ggatagcggc gtatggcgat ttctacattg cataaccact 2027881 ggttatttag tgagccgtga gcaatgtata tgcactttga gtcagcacag gatgatccta 2027941 ttacattcgc cagaaaagca gctgccgcat tcagagtagt taaaagaata gacagatatc 2028001 tgggcttccg gaagctttaa aggaggctct tttttcgagc atttttataa atcaataaaa 2028061 acaggcatct cctaaatatt tttgccgata agtttacgct aatcaactct agcactaata 2028121 catataaaaa atagaatgat atgaaaggag acttgatagt atgattgatt atcctattaa 2028181 tataaacaac gtttccggga acagtgtaat taacgtaggc ggcgctttta tgatcaggcc 2028241 tttaactttg tccaaatctg tgtttggctc cggaggttta aacacaggaa ttgtctttga 2028301 aaataacttt gtaagcaaag ctaaaatgat taatcatcaa tttactgatc aaaacgtcac 2028361 caaaactttt taatgtattc aatacacggg ggtcactaac taaacacctg gttttgccaa 2028421 ccgccatcag cattcggcgg ttttttattg aacatttttg gccaataaaa aaagcttcct 2028481 ctctaagagg aagccttttg cctgccgatt agccttctac acgaacttct ttcatgacat 2028541 cgccattaga catgtttttc gcgaattcta atccgcttgt tactttacca aatacagtgt 2028601 gaacaccgtt caaatgaggc tgtggctcat gaacgatgaa aaattggctg ccgccagtgt 2028661 cttttccggc atgtgccata gaaagtgcgc ccgcctcatg tgtatgcggg ttgccttctg 2028721 tttcacattt gattgtgtat cccggaccgc ctgtaccagt tccgtgcggg catccgcctt 2028781 ggctgacgaa gccagggatc actcggtgga atgtaagccc gtcataaaag ccttcgttcg 2028841 caagcttttc aaagtttgca acagttccag gtgcagcttc aggataaagt tcaaattcaa 2028901 ttttgttccc gtcttctaat aaaaagtaac ctgttttcaa ttgtatgcct actttcttta 2028961 ttttaatttt caaaggagat tatgtatagg ttatagcctg tctctccttg tcgcggctat 2029021 tataccacac ctttcggggg aaaacgaatc tcccgagctt tactaaaaaa taaaaatgaa 2029081 acctgaatct ctttatctcc gtctaaccta acggaactgt atttttcatg attcaggtcc 2029141 tcacaaagca gcactatcca gctgcttgtg aaattgaagg aggtcaaact gctttgaaga 2029201 aaatttggat tggaatgctg gcagcggccg ttttgctgct gatggttccg aaggtcagtc 2029261 tcgcggatgc cgcagttgga gatgtcattg taacactggg tgctgatttg tcagaatctg 2029321 acaaacaaaa agtgcttgat gaaatgaatg tccctgataa tgccacaacg gtaaccgtga 2029381 ccaataagga agaacatgaa tatttaggaa aatatatatc gaacgcgcaa atcggatcga 2029441 gagcgatttc ttcatcgtca atcaccattg ccaaaaaagg ctccggattg aatgttgaga 2029501 cccataatat cagcggcatc acagatgaaa tgtacctgaa tgcactgatg acagccggtg 2029561 ttaaagatgc gaaggtgtat gttacagcac cgtttgaagt atccgggact gccgctttaa 2029621 ctggattgat taaggcgtat gaagtttctt ctgacgaagc gatctcggag gatgttaagc 2029681 aggtcgccaa ccaagagctt gtcacgacat cagagcttgg agacaaaatc ggtaacgaaa 2029741 atgcggcagc cctgattgca aaaatcaaag aagagtttgc taaaaacggg gtgcctgata 2029801 ataaagctga catcgaaaaa caagtggatg acgcagcttc tgatttaaac gtcacactta 2029861 cagacagcca aaagaatcag cttgtctccc tattcaataa gatgaaaaac gctgacattg 2029921 actggggaca ggtcagtgac cagctagata aagcgaaaga taagattacg aaattcatag 2029981 aatcagatga aggcaaaaac ttcatccaga aagtcattga tttcttcgta tctatctgga 2030041 atgcgattgt atctatattc aaataagaaa agcgccgaaa aatcggcgct ttcttttatt 2030101 gctttacacc cgttttaaat ggcagatcaa gttttacaat atcttcgtat gtttctcgct 2030161 tcacgactaa atgagcctca ccgttttcga caaatacaac ggcgggtctc ggaatacggt 2030221 tataattgtt ggccatgctg tatccataag cgcctgtaca aaaaacggca agaagatcgc 2030281 cttcttttac ttccggcagg tcaatatccc aaatcagcat atctccgctt tcacagcact 2030341 ttccggcaat tgataccgtt ttgtcatgcg cttctccgat cctgttggct gccgcagctt 2030401 catatttagc ttggtaaagc gcaggacgaa tattgtcgtt catgcctccg tctacagcca 2030461 catattggcg gacacccggc acttcttttt gagagccaac cgtataaaga gttgtgcctg 2030521 cgtctcccac gagagaacgg cccggttcga tccaaatttc cggaatgtca aaaccgtaac 2030581 gggaagcatt ttctttcaca gcttcgataa ttttttcaac gtattcagtg gcatgaagcg 2030641 gttcatcatc ttccgtataa cgaatgccga aacctcctcc aagattcagc accttggata 2030701 caaatgaata tgaatctctc cattcgtcta gttttttgaa gattttttcc gctgctaaca 2030761 caaaaccggc cgtatcaaag atttgcgagc cgatatggca atggacaccc agcagctgaa 2030821 tgtgttccga ttgtaatact tgttcaatgg cccgttcagt ttgtccgtta tgaagatcga 2030881 aaccaaactt tgaatcttcc tggcccgttg taatgtagtc atgcgtatgc gcttctactc 2030941 cgggcgtgat ccgaagaaga acatcgatgg agtgacccgt ttctttacat aggtcttcaa 2031001 gaagcgcgat ttcatagaaa ttatccacca caatgcagcc gatgcggtgc tcaagcgcca 2031061 tccgcagttc ttccctgctc ttattgtttc catgaaagtg gatgcgttct gccggaaagc 2031121 ctgctgcaac agccgtatat agctctcctc cggatacgac atctaaagaa agtccctctt 2031181 cctcagcgag ctgaatcatt gcgactgatg agaatgcttt gctcgcatat gccacctgtg 2031241 ctttcagccc tgcagaaata aacgcctgct taaagctttt agcacgctca cgtattaaag 2031301 ccacatcata tacgtaaaga ggtgtaccat atttctccgc taaatagaga gcatccacac 2031361 ctccgatttc taaatgacca tgttgatttt gtctgcttgt gccgtgtaag aacaatgtca 2031421 ttccctcttt ctccgcttat ggatgaaagg acagttttat ggactgtccc ttcataatta 2031481 agacatacat tatcatactc ttcagtcagt ttcaatgcga ttatgaattg gtaggctgcc 2031541 ttaagcgatt tttggggtga acgatgctgg gtcttacttt tgcgccaggt ttcgctgtgc 2031601 ggacaagaac ctgccacagc gcctttccgt taaagggaat cagcggccat aagtacggtg 2031661 tctgaaggga tttgatgctt gccatggcaa taattagcac tgtaaatccg atgacgagcc 2031721 cttttatatg aaataaagca acgagtatca tgaggacaag acggctcatt ttgtttgcca 2031781 agcttaattc ataactaggc gtcgtaaagg ttccaatcgc cgcaagtgag acgtacagaa 2031841 tcacctcagg agaaaaaagg ccgacctcaa tcgcaatctg cccgatcaga acagcggcaa 2031901 ttaaacccat tgctgtcgat aaagccgtcg gtgtgtgaat ggcagccatt ctgagaaact 2031961 cgattcctaa gtcagctaaa aatatctgca ggatgatcgg gatatgcgta tctttattta 2032021 aaccgataaa tttcatgttg tccgggagca gatcaggctg aagcacaaag agaaaccaga 2032081 tcggaagaaa taaagtagaa gcaagaatac cgaaaaatct tacccgagct cgtggtcatt 2032141 cggcataatt acttaaattt tgtccagtct cccatcgtcc gctttaagaa tgtgataaac 2032201 ccggctttct tcatatcttc ttttgcagca acaggacttt cagcgagtac ttctccatcc 2032261 tttttcagaa caagagtgcc aagctcttgg cctttttgaa tcggagcact aatattgtcc 2032321 ttcatcttga tttctttttt cacatcgttc atatcctcgc cttttttcgt caatattgaa 2032381 atcggctcag atgtagtgag ttcgataaat ttttgtttcc cttttttgac ctttactttt 2032441 gctactgttt gatttcgttt atataaagga tgcgtttcat attggctaaa ggcgaagtca 2032501 agcatttttg tcacttgcgc gtttctttct ttaggcgtgc tcgctccgaa tacaaccgct 2032561 atggcccgca tgtttccttt tttagccgaa gcagtcagac aatatttcgc ttcgcctgta 2032621 tagcctgttt ttacgccgtc tacaccagga taaaatttga taaggcgatt tgtatttaca 2032681 agccaaaact ttttatctgt attttcacgc agataatctt catacgtgcc ggtaaacttc 2032741 gtaattgatt cgtatttcaa taattcctta gccatgattg ccatgtcata agcagagctg 2032801 tagtgtcctt cctcggtcag tcctgttggg tttttaaagg atgtattttt caatcccagc 2032861 tcttttgctt ttttattcat tttcttcaca aattcttctt cagagccgga aataaattca 2032921 gccatggcga cggaagcgtc atttcccgaa gcgattgcga tgcctttcag catttctttg 2032981 acagtcattt cttcgccggg ctcaaggaat atctgtgagc cgcccattga cgccgcatgc 2033041 tcgcttgtac ggaccttatc actcattttg attttgcctt tatctaaagc ttccataatc 2033101 aaaagcatcg tcataatttt cgtcatgctt gcaggcgcca gtctctcatt gctgttcttg 2033161 ttgtaaagca cttttcccgt gtcacgttct atcagcaccg cagacttcgc ttcatgagca 2033221 agctccgatg tacgttttcc gtcttgtttt gcaaatgcag acggtgcaaa tgtaagcagc 2033281 attataccaa tcaacaaagt ggataaaaga cgtttcatct caaaagccct ccatttcata 2033341 atccttttta ttttttccaa gcgtgatggt tttatacgcc actgatggaa aatgtttcga 2033401 attttgggca taaaaaaaga cagctgtgtg atatcagaca cagctgtctt ttggtcctgc 2033461 attgattcat atttattcgt actgagcgac gatcgcttta acaagcttta agaatccagc 2033521 ttttactttt tcggtcactt ccataacttc atcgtgactt aaaggctgat ccagaattcc 2033581 ggctgccgcg ttagagatgc aggaaatgcc aagaacccgc attcccgcat gattcgctac 2033641 aatgacttcc ggaacagtag acatgccgac tgcatcagag cccatcgttc ttaagaaacg 2033701 gacttctgcc ggtgtttcgt aagaaggtcc tgtcacagca gtgtacacgc ctttttgaat 2033761 tgggatatta aggtctttcg caatcttttc agccaggctg gacagatctt tgtcataggc 2033821 tgaagacata tctggaaatc tggcgccgaa atctgcttcg tttggcccga ttaacgggtt 2033881 tgttcccata aagttgatat gatcggtaat aatcattaaa tctcccgcac ggaattcagt 2033941 gttgacaccg cctgcggcat ttgtcacgat caacgcttcc acaccgagcg ctttcatcac 2034001 gcgtacaggg aatgtgactt tctccattga gtagccttca taaaaatgaa agcggccctg 2034061 cattgcaatg acggaaactc cttcaagagt gccaagcaca agctgtccgg catgcccttc 2034121 aacagtagat accgggaatt caggtatatc ttcatatttc agcttgaccg gattttcgat 2034181 ttcgtccgcc aaaatgccaa gacctgagcc taaaataagg ccgatctttg gagattccgg 2034241 caggttttgt ttaataaaag cggctgcgcg ttcaattctg tccttcaaga aacagtcccc 2034301 ctattgtaat aaagataaaa agcttttccc gtatttcggt ttatttgttt ggaaattatc 2034361 agcgatcgtt gcgccaatat cggcaaatgt atctgcaagc ggcagcattt gcgctttctt 2034421 atgttttttg ctgtaagcga gaatcggcac atactcgcgt gtatggtcag tcccatgatg 2034481 aatcggatca ttgccgtggt cggctgtaat aattaacaga tcgtcttctc tcattttttc 2034541 aaacacttcc ggaagccgcg catcaaattc ttcaagcgcg cgtccgtagc cttcagggtc 2034601 acggcggtgt ccgaataacg cgtcaaaatc aacaaggttc gcaaagctca gacccgtaaa 2034661 atcttctccc agcgtatcga tcaccttgtc cattccgtcc atattagaaa ccgttctgcg 2034721 tgaagaagta atgccttctc cgtcgtaaat atcagagatt ttaccgattg aaatcacatc 2034781 taagccgcag tctttcaatt cattcatgac agtgcggtca aacggcttca gcgcataatc 2034841 atggcggttt ggcgtccgtt tgaattgacc cggctctccg acgaacggcc gtgcaataat 2034901 gcggccaacc atatatttcg gatcaagcgt cagctctctc gccgtttcgc aaatgcgata 2034961 cagctcctca agcggcacaa cctcttcgtg agcggcaatt tgcagaacag agtcagcaga 2035021 cgtgtaaaca attaaagccc ctgtctccat gtgctcctgg ccaagctcat ccaaaatcgc 2035081 tgtgccggaa gccggcttgt ttccaataat tttgcggcca gatctctttt ccagctcttg 2035141 aagcaattca tcaggaaagc cttccgggaa cactttaaac ggtttatcaa tgtataaacc 2035201 cataatctcc caatggccgg tcatcgtatc tttgccgttt gacgcttctt gcatttttcc 2035261 ataataggca agcggatgtt ctgttttttc tacacctttg atatcttcga taagaccaag 2035321 gccgagcttt gccatattcg gcatatgtaa tccgttcata tgctcggcaa tatgaccgag 2035381 cgtatgagcg ccttcgtcat taaagtcagc ggcatccggc gcttcgccga ttccgactga 2035441 gtccatcaca attaaaaaca cacgattata tttgtatgca ggcatcttga aagcctcctt 2035501 tttttctata cgtctattgt atcgctaaga ggtctgacaa ctcaagtata aaccgttttc 2035561 attcccgttg acaatgtatt tggaaataat gagaaacttc aatattttct gtcgctctaa 2035621 acaaaaaagc cgcagccacc tgcggctatg ctcgcggatg aaactgcttg tacacatcct 2035681 tcagccttgt tttcgtcaca tgcgtataaa tttgcgtcgt ggatatatcc gcatgaccga 2035741 gcatttcctg caccgctctt aaatctgccc cgttctcaag cagatgcgtc gcaaaggaat 2035801 gcctgagtgt atgcggagtc agctctttct taatgccggc ttccaatgcg atttttttca 2035861 ggttcttcca aaatccctgg cggctgatct gtttgccgtg atgatttaaa aagagggcgt 2035921 cagatacatt attttttaac agttttcccc tggcttttgt catatattcc tcaatggcgg 2035981 aagcagcggc ttcaccgatt ggcacaatcc gttcttttct tcctttgccg aagcatcgga 2036041 taaaccccat agataaatga acatcagccg ttttcaattc aatcatttca ctgactcgta 2036101 tgcctgtcgc ataaagcagc tccagcattg ctttatcccg atatccgaaa gggctcgtca 2036161 gcttaggcgt gtccaataac cgctcgactt cattgagcgc gagcaccttc ggaagcgccc 2036221 gttccgtctt ttgtgtttcg atatgaacgg aagggtcctt atccgttact ttttccctga 2036281 gcagaaattg atgaaaagag cgaatggatg ccaaatgccg cgccgatgtc ttgccggatt 2036341 tccccgagtc cttcaaatgc tttaagtatt ggataatatg tatgcgggta acgtgattcc 2036401 aatctgtaac atgaagggtt tctgttaagt agagagaata gcttttcaag tcacgttcat 2036461 aggatacgat cgtattttga gagagccctc tctctaccat aacgtagtgg atgaaatcct 2036521 ttatttgatc tttcactctt gatctactcc ccgttttggt aaaaaaagat caaccggtcg 2036581 aaccatccgc ctttttcatc ctgatccatt tcaacaactt ttacagcgga gccttccggt 2036641 ttatcatacc gatgatagtt ttcatactct tgattcaccc atatcatagc ataatagaac 2036701 aaagcggtaa aaccggtaaa caggatgaaa actttcaatg catcgacagc tgttttcagg 2036761 aatcttccca tgtcctaatc gatcctttcc ctatggttcc agttatataa accatatgcc 2036821 aaatcagaaa ggttttatac atagaaacag caaaaaaccc tttccccatg agaaaaggtt 2036881 cgcgctcggc accgtctatt cagtttcttt tccgttacag cggtggcaaa tgccgtgaaa 2036941 cgtcaatcta tgatctttaa tcttaaattt ccaatcacgt tcaatgattt cttccacgtc 2037001 ttcaagcaaa tcttcttcaa tttcatcaac ggctccgcac tccatgcaca ccaagtggtg 2037061 atgaaagtga gctgcgccct ctttccgaag gtcgtaacgg gacacaccgt ctccaaagtt 2037121 aattttatct acgactttta attcagttaa taattcaagc gtacggtata ctgtagcgag 2037181 accgatctca ggagatttct cttttacgag gaggtataca tcttctgcgc ttaaatggtc 2037241 ttcttcgttt tcaagcagca ctcttactgt cgcttcacgc tgtggcgtaa gtttatagct 2037301 ggatgagtgc agttgtttct taatacgatc aatacggttt tccatgtctt tccctcctac 2037361 gccgcattcc atgactcatt ataacaaaat acgcgcagag ttccaactat aattattata 2037421 aactgataaa taaaatggtt ttcttttaat aatgatttta aaaaagtcta gatgtaagct 2037481 tttccattaa aacaggagat aagtatgctt caaagagaga tgaaatcagc gctaaaaaca 2037541 gaatgaccag cagcacaaag gcataccgcc cgaaccattg aatcggcgcg tcatgcaggc 2037601 ttcgtttcac gaacagctgt ctgattaact ttaaagaaaa cgcaattgca catgtgccca 2037661 taatgagata agccggaatc agcagcacat tttgcggcaa aacggagaca aatgatagga 2037721 aaaacccgct tactcccatc tgattgacta ggaacccgac agtaaagccg acgacgatcc 2037781 ctttcagaaa gatcataatg aaaataatcg gcatcccaat gacggaaatt cccagtatcc 2037841 acatcaggcc taaatacttt gcattatgaa agatactttg cccaaacata tcagctgaac 2037901 ttgcctgttt tccatccgaa agctgtccaa aaaattgact taagtagtag tataaatctt 2037961 ctttctggct gatggtcata ctgttgacaa taatcgcgcc aaagatgaca cccatgaaaa 2038021 acagcactga cacaaatata taaagagaga gatgatcttt gacatgcctg agaaacatgt 2038081 ccttataaga gatttttcgc ataccgtttc ctcccgcccg ctctagtgat ttgatttaat 2038141 agattgtatg aaagaaacag aaaaacatgc cctttttcaa aaagaaacaa tagagatgaa 2038201 tgctaggcgg ctttttgggg cacaaaaaaa tccttatcat caactgctgt atgatcataa 2038261 ggattcttat gcttccgttt attcaaaatc tcttttttgc tttttgtcat tcttccatgt 2038321 gtgctgaaag atggtgtgct gcctcttgat aataagacgt cacgtccgcc gtttctcaat 2038381 cgatgccccc gcttcttttt cgcttggctt tttgccatgt gatcactccc ttttttattt 2038441 tcatagtaat gataacaaaa ttgaacaatg ataagaaaaa aacagcacct gctacgacag 2038501 gtgctgttta gctacattta tttcactgct gtaagagctg catgctcgac agctgctgct 2038561 accgcatgat ggacttttga atcaagcggc tgagggacaa catcaccttg tttagtgcaa 2038621 gctgcgatgg cctctgctgc tgcgacaagc atatcatgat taatctccgt gctttttgcg 2038681 ttaagcgctc ctctaaaaat ccctggaaaa ccgagtacat tattaacaga acgcccgtca 2038741 gctgcatatg cggcgccagc ctgcagtgcg gcctccggct caatttccgg cttcggattc 2038801 gataaagcca gaatcacttg accagaacgt acaaatgccg gttttattaa acccggaacg 2038861 cccgttgtag caatgacaat atcacatgtt tccataagct cctcaatact ggaaactgcc 2038921 tgtccgccgt attgttcgag acggttcatt gctgactctg atttgtctgt tccgtataca 2038981 gcattcacac cataagccat gaacatccgg cagatggcca cgcctgctgc gccaaggccg 2039041 atttgcccca ctttcgcttc cttcaggtca acccccgcac tcctgcatgc cgaaatggca 2039101 gctgccagcg tcactacagc tgtaccatgc tggtcatcgt gcataacagg gatgttcagc 2039161 tcctctttta ggcgatcctc gatttcaaaa caatgcggcg aaccgatatc ctcaagaagg 2039221 atgccgctaa agcccggaga aatatgtttt actgttttga tgatttcttc aggatcactc 2039281 gtatcaagca gtatcggaat gccgctaata cccgccagct gatcaaataa agcagccttt 2039341 ccttccatga caggcatgcc agccacagag ccgatattcc caaggcctaa aattgcggtt 2039401 ccatccgtta caattgcaac agaattgctg atcgttgtat aaatagaagc tttttcaggt 2039461 tctttttcga tcagtcggca cacgtccgca acacctggtg tgtagacacg tcccagctct 2039521 gccagtgaac ggatcggcat tttgcttttc atttggattt ttccgccttc atgtgcggac 2039581 aggacttcat cagatacggt gtgaagcctg atcccttctc cgagggcctg tacagccgcg 2039641 atcacttcct gaagctgttc ttcattctcc acttgaacgg taatattccg cattgtgtaa 2039701 ttgggtccga cttttaccgt ctccacttca ccaatatccc cgcccagaag gccgatggcc 2039761 gtagccaccc ttccaagatt tccgggaacc gaaggcgttt cgatcatcag tgtccgaatc 2039821 atgtgtttcg ctatcattca gtgatcctcc cctattagcc tagtttttcg gctttaactg 2039881 tattgttttt cgtataccat ataaattttc ctgtataacc atagataatt gcaagaccta 2039941 ttgctacaaa actgagccac ataaacggca gataagagaa ggtagaaaca cctaaaatac 2040001 cagccatgta aatcccatta tcagaccaag gaaccatccc cgaagtcaat gttcccccga 2040061 cctctgagtt acgtgataac actcttctgt ccagatgtaa gcgatcatag ctgtcttcca 2040121 taattttcgg agtcaaaata agagatacat acatcgcaca gccgaagatg tttgctaaaa 2040181 acgctacgat cagtgtagac aatgtgacat tgccggctga agttaatttc ttttcaaacg 2040241 ttgaaacaat gacttttaac acgccgagtt tctcaagcag accgccaaaa ccaaggccaa 2040301 agatgatgac gacgagagaa tcaagcatac cgacaattcc accgcggttt aacaagccgt 2040361 tcaaaaattc aacatccgtt ttaatagaga agccgttgta cgcagttgca atcgcatggg 2040421 caatatccat tccttggaaa acaacagccc agattgcacc gagtaaagcg ccaattacga 2040481 taactggcat agatggcttt ttcatcgcca ataagactat gacgagaact gccgggatca 2040541 gcatccaaat atgaatgtca aacgtgtttt gcaaagatga ttttaagaat tcaactttat 2040601 caagatcaat atttttcccg ccgtacataa atccaacaac tgtaaagagt atagctgtaa 2040661 tgacataagc aggtattgat aaataaagca ttgctctcac gtgagccaat acatcgactt 2040721 ttgatagtga agaagctaga actgtactgt cagacagcgg agacagcttg tccccaaaat 2040781 aagcacctga aagaatagct cccgctacta gaggaagcgg aatgcctaac ccctctccaa 2040841 ttgcgatcat ggcaatgccg gcagttccga ctgttcccca tgacgttcct gttgccacag 2040901 acataatgga acaaataatt aacgttgcca gtaaaaagat acttgggtga ataaattcca 2040961 gtccgtaata aatcaaagtc ggcacaacgc ctccggcaat ccatgttccg atgagcgccc 2041021 caactgaaac gagaatcagt acggcttcaa ggccatttga tatcccatgt acaatcgcat 2041081 tttgtaaatc tttataagaa taaccgagtc taatacctaa aagcattgca ataaaccatg 2041141 aaacaaaaag cgccagctgt atcggcaagt cgagaaagac tgtaaacgat agaacaagtg 2041201 ctaaaaatac tcctagtaca ataataattt caaatagtgt tggcaatctt acatccttca 2041261 aaagaagtcc cccttcatgt aaaagctaaa acgctttcaa tatatagtgc aacacgtata 2041321 ctatacttcc tcatccctat gttgtaaaca gcttattcat ccgactattc ggagatgaat 2041381 aagctgtatt ttatacaaat tttatttttc taatagttct ttccctgcga tacctggttt 2041441 ggtcatctca tatgggttta aaataatatc caattcttct tcagtcagca catcatgctg 2041501 cagacaaaga tcccggacag attgccctgt cataattgct tccctggcaa ttctagctgc 2041561 cgcttcatac ccaagatgcg gattgacagc tgtgatcacg cctgcgcttt tttctacgta 2041621 ttgcttcata cgcttttcgt tggcttcaat gccttttaag cagttgtcag tgaacgaacg 2041681 gaagccgttg ttcatgatgc tgatggattg aagcaaatta aagacaagca cgggctccat 2041741 gacgttcaac tcaagctggc cggcttctga agcaaggcag attgtattgt catttccgat 2041801 aacctggaac gcaatttggt tgatcagctc cgccataacc ggattgactt tccccggcat 2041861 aatagatgaa cccggctgac gtgcaggcag agaaatttcc gcaagtccgg cgcgcggtcc 2041921 cgacgccatt aagcgcaggt cgtttgcgat cttcgacatg ttcatcatgc agacttttaa 2041981 tgaagctgat acctctgtat aggcatctgt attttgtgtc gcatcaacaa gatgatcagc 2042041 gccgacaaga ggaagcccgc taatatcagc aaggtgcttt actacctgtt tgatatattc 2042101 aggatcagcg ttcagccctg taccaacagc agttgcgccc atgttgactt catacaggtg 2042161 ctggcgcgat tgcttgattc gtttgatatc acgctcgaga acacggctgt aagcttcgaa 2042221 ttcctggcca agacggatcg gaaccgcatc ttgaaggtgt gtccggccca ttttaataac 2042281 agagtcaaac tcctgtgctt tttgcttaaa cacactatgc atatcttcca ttgttttcag 2042341 cagtttttct aagagcttca atgtggaaat atggatagca gtcgggaaca catcgttcgt 2042401 agactgtgac atgttcacat gtgtgtttgg acttaaatgg atataatctc cctttttatg 2042461 tcccatgatt tcaagcgccc ggtttccgat aacctcattc gcgttcatgt tcatagaagt 2042521 tccggcaccg ccctgaatcg gatcgacgat aaactgatcg tgccacttgc cttccagaat 2042581 ctcgtcagcg gcttgtacga tagcttggcc aattccttca tacagccgtt tcacgtccat 2042641 gttggcaaga gccgcagctt ttttcacaat cgccagtgcg ttaatcattt cctcatggat 2042701 tttgtatcct gtgatcggaa aattttcaga agcacggagc gtctgaattc cgtaataaac 2042761 atctgcttca atttgttttt ccccaaggaa gtctttttcc acgcgatatt ctttttggcc 2042821 gtttaacata atctttaacc ttctttctct ttgctggtta tcgtttttac attttacagg 2042881 acaacgtcat cagctatcgg cgtttccata attctcttga cgacaggaag atccgaagac 2042941 tgacctagcg cccacatcaa ttttggcaca attgcttctg tgttcatatt tcttgatcgg 2043001 ataattaagt cttggttgac tctgcggcca acctcgtaaa tgctcatgtc ttcgccttct 2043061 tcaagacatt gagtcgtaat gacgacgaca atgccgcttt cgatcagttc attcactttt 2043121 gacaaaatgt ctctgccttc aaacggcact cctccgctgc cataactctc aatgacaatt 2043181 cctttgtaca tgcttttcag ggcatcaaac atttcgggct ttaagcctgg atgcagcttc 2043241 agcagacata catctgtgca tagtgaagtg tcaactgtga aggtgtcgtt ctcaggttcc 2043301 gttacttgtt tgttgtattc gatcccgtct tcattgataa aagcgatata tgggtaattg 2043361 atgctttcaa atgcgtcgta gcttttcgtt cttaatttga tcgcacgcgt tccctgaatg 2043421 actctgccgt caaacacaac ataaacgccg cccacgcctt cacaggcaaa tcgaatggca 2043481 tctgtaatat tttttttggc atcggttttt tggaacgtga tcggaatctg cgagccggtg 2043541 atgacaatcg gctttttggc atgctgcagc atatacgata gtgcggcaga tgtataggcc 2043601 attgtatctg taccgtgagt aataacaaac ccgtcatagg catcataatt ttccttaacg 2043661 gcttctgcta tttccaccca gtattcaggc tgcatattgg tgctgtctat attcataagc 2043721 gactgagttt ccattgtgta atcgttatca agttttgata cgtaacttaa taattcatca 2043781 gccttgactc cgggagccag cccattttcc ccttcaactg aagcaatcgt tcccccagtt 2043841 gtcaacatca ataatttttt cataccatgc acctcttcac tgtatctaaa gatgggttgc 2043901 gagaaggtat tcgcttttcg catactttta atgcaattat agacacggaa aataaaatac 2043961 gcaagacatt attattcaat tcgcgtacac ttcctaatac ctatatgata taatcagctc 2044021 aaggtgaaaa aggagcggaa gttcatgaat ctagatcgtt taactgaatt gagaaaaaag 2044081 aaaaattggt cgcttcaata tacagctgac cttctcggta tcgcaaaaag cacatatgcc 2044141 ggctacgagt caggctaccg acggccttca cttgaagcgc ttgccatgct ggctgacctc 2044201 tttgacacaa cctgcgatga acttttaggc cgcgagaaac aaaagcagac tgctcctcag 2044261 gccatagaat tggccacgtg gagcagcctc gactttacca tttctgttga tggccagccg 2044321 ctgagtgaag atgaaatcat ccagctgatt acctttatac gcacaaaaag aaaagtacag 2044381 gaggaactga gttaatcttt agctcacggt ttaattttac cgtaggttcc tcctcctccg 2044441 gctttcaatt ccagttttcc ggatctcgct tttacgataa gcgccgcggt tttcggcggg 2044501 acaacgcgag ccaaatcttc ttctgcagcc tcatgaagaa cagccatttc tgttccgaag 2044561 gcttttttta gtttgtccag cgttttcggg cctacacccg gaacaaattg cagcgggatc 2044621 tgatgtacat atcgcggacg cgggacgcga acttcaagct gatcactcaa ttcacgcaat 2044681 ctatcgctga ctcccttggt aaatctggct tttccgcaat tcgcgcacgc tgtttccccg 2044741 cttacagcag gctctccgca cgcttcgcaa gccgtctgat aatatttccc caataacggg 2044801 tccaagccat aatttgcgat aattttcctg tcatcttgtc cctttaatgc aagagcaaat 2044861 tcagtaaaat cagctgactg cacatataat tcattatatt ctctgccgat tttccccaac 2044921 gaatgcgcat cagaatttgt taaaaaagga tacggattca attgcgatac gtgtgatgcc 2044981 atgtctgtat cacagcttaa tccaagctcc accgcgtcta tcatagatgg atcaaaaacc 2045041 tcagttaagc ttgatttaac cccttttcca tataagcttt tatgcggcgt aaagatatgg 2045101 gcggggataa acaggccgcc catatcctgc actttttttt gcaggtttaa gcccgtttca 2045161 taaatccgct gcgagcttaa atgaatattt ttcagccggg ctgacagcca gtttgaaaac 2045221 tgtttcatat cagccagcgt cggcataaat acgagcacat ggatcggtcc gctgcaggct 2045281 tcatcataaa tctccagctc gctccccaat aaaagagtcg tgctgcgata acggattcct 2045341 cccccgtcaa gctcgcgata ttttccagat gaaatgcctt cctcaagctc tagaatgact 2045401 tccggagaat gacagtcgat aatgccgagg agttcaattc ctttatgttc actggcttca 2045461 accaaaattc tgtccagcgt taatgttttg gcgcctgtta ttttgacagc ccttcctgta 2045521 aaggtccggc cgatatgaat gtgcaaatcc gcgtaaatct ttttcatttt tgtgcttgga 2045581 gcgcttcttt cagctgaaga tactgaatcg cgtaggctgt tttagcatca tatacttcac 2045641 gcgattcaac cagctttagc gcatcttcaa gcgtcacctc catcacttca acaaactcgt 2045701 cctcatcaag ctcccgtttt tcttcaagca cagaaagctc ctcagcaaga aaaacgtgaa 2045761 cgatttcatc tgcaaatccg ggtgatgtat aaaacgcagt tatttttgtc agtttttttg 2045821 ctgtataacc ggtttcctct tcaagttccc gaagtgccgt atactccggc tcctcacctt 2045881 tttcaagctt accggccgga atttcaacga tcgtccgctc aagcggctta cggaattgtt 2045941 tgaccatgat gattttccct tcatctgtga cggctagtac cgctacagct ccagggtgtt 2046001 tcacaatttc acgtttactg gctttgccgt ttggcagctc tacatcctcg acataaagat 2046061 caatgacttt acccgaaaaa atctgttctt tggcaattgt tttttcttct aatgatttca 2046121 tttcttcatc tcccgttctg tctctatatg atgccccata cattttatca tactagagca 2046181 aaagggggct tcttcgtgaa agtgcaccgc atgccaaaag gtgttgtctt agtcggaaaa 2046241 gcatgggaaa ttcgagcgaa gttaaaagag tatggacgca catttcaata tgtgaaagat 2046301 tggatctcaa agccataaaa gttgaaactt tagctccttt atattacggt caatacaaag 2046361 cctaaaaaag gagtgtgcac atgagaaagc gcaaattggg tacatctgat ttagacatta 2046421 gcgaagtcgg actcggctgt atgtctcttg gaactgaaaa aaacaaagca ttgtccattc 2046481 tggatgaagc gatcgagctt ggcatcaact atttggacac agcggatttg tatgaccggg 2046541 gacgcaatga agaaattgtc ggtgatgcga tccaaaacag acgccatgat attattctgg 2046601 caacaaaagc gggaaaccgt tgggatgacg gaagcgaggg ctggtattgg gacccttcaa 2046661 aagcttacat aaaagaggcg gtaaaaaaga gccttacacg tctgaaaaca gattatatcg 2046721 acctttatca gctccacggc ggcacgatag aggacaacat tgatgaaacg attgaagcgt 2046781 ttgaggaatt aaaacaagaa ggtgtcatcc gctactacgg catttcttcc atccgcccga 2046841 atgtgattaa agaatatgta aaaaaatcaa acatcgtcag cattatgatg caattcagcc 2046901 tgtttgacag acgccctgag gaatggctcc cgcttttaga ggaacatcaa atcagcgtag 2046961 tcgccagagg tcctgttgcc aaagggctct taactgaaaa accgcttgat caagcttcag 2047021 aaagtatgaa acaaaacggg tacttgtcct attcattcga ggaactgaca aatgcccgta 2047081 aggcaatgga ggaagtggct cccgatcttt ccatgacaga aaagtcgctg cagtatctgc 2047141 tagcacagcc ggctgtcgct tcagtgatta caggcgccag taagattgag cagttacggg 2047201 aaaatattca ggcagcaaat gcacggcgtt taaccgaaga ggaaatcaaa gcgctccaat 2047261 ctcatacgaa acaagacatt tacaaagctc atcgctcata gcagaaaaac cagcacctgt 2047321 acgggtgctg gtttatttat attgatgcca atccatttgg ctttcattta ggagttcttc 2047381 aaagctctta tttttttcga tctctttttt ctttctaatc tgttctgctt tttctctttt 2047441 ctgcctcttt tcatcctctt ccttcaattg gctcttcatc tccataagct ttgctttgat 2047501 atcggattga aggccgtctt ttagctggtg tttgtcaatg gatttttgtt ttttcatgca 2047561 gacttccccc atgttttgtt ttgaagccag tttatcacgg agcatataaa ctgaacaagc 2047621 agactctctt ctgatcactt tctcagcgta gcagtgttta ggtataatga tcttaaacac 2047681 gaattgccta tatatttcgt tgaaaggtgc tgtgactttt gaagaaaatc cttttggcca 2047741 ttggcgcgct cgtaacagct gtcatcgcaa tcggaattgt tttttcacat atgattctat 2047801 tcatcaagaa aaaaacggat gaagacatta tcaaaagaga gacagacaac ggacatgatg 2047861 tgtttgaatc atttgaacaa atggagaaaa ccgcttttgt gataccctcc gcttacgggt 2047921 acgacataaa aggataccat gtcgcaccgc atgacacacc aaataccatc atcatctgcc 2047981 acggggtgac gatgaatgta ctgaattctc ttaagtatat gcatttattt ctagatctcg 2048041 gctggaatgt gctcatttat gaccatcgcc ggcatggcca aagcggcgga aagacgacca 2048101 gctacgggtt ttacgaaaag gatgatctca ataaggttgt cagcttgctc aaaaacaaaa 2048161 caaatcatcg cggattgatc ggaattcatg gtgagtcgat gggggccgtg accgccctgc 2048221 tttatgctgg tgcacactgc agcgatggcg ctgattttta tattgccgat tgtccgttcg 2048281 catgttttga tgaacagctt gcctatcggc tgagagcgga atacaggctc ccgtcttggc 2048341 ccctgcttcc tatcgccgac ttctttttga agctgagggg aggctatcgc gcacgtgaag 2048401 tatctccgct tgctgtcatt gataaaattg aaaagccggt cctctttatt cacagtaagg 2048461 atgatgacta cattcctgtt tcttcaaccg agcggcttta tgaaaagaaa cgcggtccga 2048521 aagcgctgta cattgccgag aacggtgaac acgccatgtc atataccaaa aatcggcata 2048581 cgtaccgaaa aacagtgcag gagtttttag acaacatgaa tgattcaaca gaataaaaaa 2048641 gcgaaaggcc tcttcggctc tttcgctttt ttatgttaca gaacgtcggt aatgccatcc 2048701 atattttctc tgatccattc aatcgcaaga tctatcgttg taaactcctg cgtctcgaag 2048761 gtcatttcat cctgcaatag ccagacatct ttcttgatgg actctgctcc tccgattgac 2048821 cagtgaagca aggtataagg atggttttga ttcaggaagg atacccacgt tttattttgt 2048881 gctgtgttct tcattgcctt cagcttttgt tccacgtttc gcgtctccta ctttactaat 2048941 atgctcattc tggggctgag catttcagcc gggcttttca gcgccaatgt tttggctttt 2049001 tcattgtaat cgatcgtcat ttgatcgtca aaaaacactt tttgcgacga ttggatatac 2049061 agcggaatgc cgttcgtttc cagctgctcg cactgtcccg ttaattcttc tgccagccag 2049121 attgtcggga caccgcttac cgcgcagccg catccttctg catcgtaacg aagctgggct 2049181 ttttttcccg ggttggcgtc aaacgcctgc tgcagtgcct gttttgctgc atctgtcaca 2049241 tgtatgttca taaggtgaaa cccccgtttt catcattttc gctattgtag catacaatac 2049301 tgccattcgc attgtttctg ccttttttcc accgcttcgc attttcttct gcagtcttga 2049361 tccactcatc tttcccttgt atatactgat tgatgctgtc agggtgctgg gccgccagct 2049421 gttttttgag aacggcgtat tctttcgcta tgtttggatg agctctgaga taatctctga 2049481 ataacagatg cctttcaata gcagggtttc cctgttcgta catatggaca tgatgagtgc 2049541 gtttatttcc gcccttttgg aaataacgcc tgcccgctat accgttctca ccttttggtg 2049601 tatagccgtt ggccttcatt tgttcatcaa attggctcac ggcttcaatg cttctgactt 2049661 caattaacat atcaatgatt ggcttcgctg ccatgttagg tattgatgtg cttccgatgt 2049721 gatgaatagc gataatctcc ggcccgaaca caagtttcag ccgttctttt tcttcatcga 2049781 aacattctgc ccatttttcg ttgtagagaa tgatctcaac ttttcttttc ggatacaaat 2049841 gaaagaccga cagcaataga ccctgcgctg ctttgacggt ttctgccttt tggaatccgg 2049901 cctgtgtata gagtgacaca gccggggtat tgttctcggc tgtgactact tcgattttct 2049961 cagcgtcttc attatgatca atgacaaatt gcagaagcgc tcgtccaatt ccttttctga 2050021 aaccgtcagg atgcacaaca agcctgcaaa tggtgagata atgcatgttt ttctcatatg 2050081 aaatgacacc gatcagcttg ccgtttttcc gatatcccgc aaaccgttca tgggatgctt 2050141 gaatatcctt taccttctct tgtaaagcgg gaataccgtc aaaaccgata atctctgttt 2050201 cctttatgta ggcggggatc tgtacggcta aaatctcacg cgctatagtg gcttccttat 2050261 gctggagaaa ttcaatcatt cgtgttctcc tgaaacagcc gctgtctgtc gacttttgcg 2050321 acgcggactg catacgactc gtaccaaacg cttcttcctt tttcttttgc tgcttgatgt 2050381 tcagtgtgat gcctccaatg gttaattgcg tccatactgt cccaatagga aactgtgatg 2050441 ccccttccat ccgcttcacg tacgctttcc acgcctaaaa atccaggctg atccgccgca 2050501 agtgatacca tccgctccgc tgtttctcca tatcctgtgt cattttcgct tttgacagaa 2050561 gaaaaaatga ctgcatagta aggaggctca ggtgtttttg ataaaaaatc catcatattt 2050621 ccccctcata tgtttttgac aaatagtacc ctgtcttggc ccgggccatc atagtttgca 2050681 aacactgaga tgccatttac cgttttggtg cccttttcaa tatcaaaccc caattttgtg 2050741 tgatatgcga ttgatacctt attcacaggt gaagtgacac acttcacccg ggtgcagccc 2050801 ctttgtttta ctgtttcgat aaatacatca tacaattgtt tcccaatttg catttttctg 2050861 aaatccggat gcacaccgga aaaatgaatg tacgccgttt caggatcgga ttgcgattga 2050921 aatccgatta aaaatcccgt catgctgtta tgttcggatg taataaagct tgtgtcctga 2050981 aaatgctcaa aaaatagtct cggcaatttt tctttcagct gtctgccgcc ccaccattca 2051041 ttcagtacag acgttaccat ttcataatct gaagacgtga ttgttcgaat atccattacg 2051101 atttgatctc cctccgtctg gcaaaacgaa tgtcagctct ttttctcaca atataaaaat 2051161 tatattttgc ctggctggaa ttgtaaatgc cttctttcct gtatcatacg tttccagact 2051221 gccgagggaa caatgtttga tcattttacg cctatttctc ccccaaacag gaggagagac 2051281 tttacagcac aatatcaagc acttgatcaa gtttcagctt ataaagctga tcctcgtctc 2051341 cttttatcca tactgctttt tcaaactctt cataccggca gattttcccg gtgcagcaga 2051401 caatctcacc gtcctgaaag cagctgacag tgatatcctg agcaaactcc atcgcggcgc 2051461 aaagcgtttg attcatctct tccagcttat cggggtcaag gatcggcttt tgcagcttct 2051521 gtttaagtcg ctttctctcc agcaggcttt gcttatgttc cggcagaaac atcctgctcc 2051581 cttcccacag caggttgccc ctttttaaat ggtcgttcat ttataatgcc cccctatttt 2051641 agccgcacgt tcaaatgcct ggcctgccgc tgtcagtgac gccgccctga tgattgctgt 2051701 atcgccgaat cgatttttaa tgccatccat cacatagcct aggctcattt tctttgcata 2051761 atcctgaaat aaattgagct gccatatgtc atcagatgag agctgagaca gattgacacc 2051821 gaggcggcgg acgggtttcc cgtcccaaaa tgtaagaaac agccgtcgta cagcctcata 2051881 tacatcctgc gtagaattag tcggctctgc cagcttcact tgccggttga agcccgtcgg 2051941 ccaatcaaaa tcagcacccc ggcagctcac tgacactgtc tgccccatga ccccggcgtt 2052001 tcggcttcgc ctgcacacct cttcactcag ctcaagcaat acgaccttga tttctttgtc 2052061 aaagtgttcg tagtctctcg ggagagtcat tccatgacct atcgcctttt gcccgtccag 2052121 agacgaagtt gacacagggg aatagtcgat tccgtttgcc gtcatccaca gcacgtggcc 2052181 gttaatgccc catttctttt ttaaaagatc gagcggaaaa gccgcgagcc cgccgatcgt 2052241 gctgatgccc attcgattta aatgatgctt catgcggctc ccgacgccaa acatgctgcc 2052301 caccgggagc ggccacattt cggttttcat attttctttc gttaaggtaa aaataccgtt 2052361 cttattcttt ttggcaaaat tgtcacacgc aattttggcc agcgctttgt tagggccgat 2052421 tccgacccgt gcataaacgc cgatctcccg catgattctg ccctgaatgc ttttcgcgat 2052481 ctccatcggc gtcccaaaca gcttctggct gcctgtaatg tccatgaact gttcatcgat 2052541 ggaatacggc tccacaaggt ctgtatactc ctcgagaatg gccgtaattt gcagtgatac 2052601 atcaatatac cgctgcatac gcggccggag cacaacagcc tcaggacact tttcctgcgc 2052661 ctcccacagc cgtgaagcat tcaccacacc cttttgtttc gccagcgggc aggcagccaa 2052721 tacgactccg cccctttttt cagggtcacc cgaaacaatg acgggcctat ttttcaaatg 2052781 tggattttcc gctttctcta cagatgcata aaacgattgc atgtcaacga gaaaaatcac 2052841 tttttctttc atcatacaca cctctaaaaa gaacttatgt tcgcttttca ttatatgcga 2052901 aagtatgttc gttttatact ggtaaatgat tcttgtctga cagaaaatat gatccaaggg 2052961 tttgagagaa gaaaaacatt tagtagaata aaagcgaagc ataaggatag gagagtcatg 2053021 atggagaaat ttgtcgaaaa aatgctggga caggcattgc ggcaatacgg cagaaacgtt 2053081 gctatagatc cgttaagccc gtatgaaaaa caaagcctga aagcggctct acaagagaga 2053141 cggaatgaag aaccagatga ggatttgcat gcgcatatag aagatatcat ttatgactat 2053201 gtcacaaacc aaggcctgtt ctcttaaacg catgactgtc agttctttca gccgctgatg 2053261 cggcttccct ttgaaaacac cgcctgaaac aaataaacag tctcaggctt acagaaaaaa 2053321 agcaggattt tctcacgctc catagattca tatggcctgg cgtaaaattc ccctcaatgc 2053381 tcgcgcaaaa cggaataagc tgtccatgat cacgcgtata cactttttcg aagagatgtg 2053441 ctctcttgtt ctgtcatgcg gtccatgccg gttttcagcg tacatcttga tctcatagcc 2053501 ggtttcactg ccgatatgat ccacgttctg gcggcttaaa ctaacacacc ctcactgacc 2053561 aatcgctttg cttttcatcg gacatcccgt cattttcctt ctttcaagat gtaaactccg 2053621 tcagccacac gcatcctcaa cgcatagtat attgccatcc atacaatcag gcatactaca 2053681 tgtcaataac gaaatatttt gaacgatcta ttggagaagg aaattttttc atatatgata 2053741 gagaaagatc atacatacag gagagaatat aattcatgaa gaaatggaaa gatatccacc 2053801 cgatcagctg gacaattata atcggaacca ttttcggcag aatggcaaca tcgatgagca 2053861 ttcctttttt agcgatttat ttgacagccg tccaaggcgc atcagcttcc tatgcagggc 2053921 tggtcatcgc cgcgagctca tcagtcggca tcctcgcaag cttttacggc ggatatatct 2053981 cagataaatt cggcagaaaa aacatgatgc ttgtatcgat tttcggatgg atgctggtat 2054041 ttgcaggctt tgcggcagca tctaatctct gggtgttttt tgtagtaaac gcattaaacg 2054101 gtctttgcaa atcactgttt gagcccgctt caaaggcctt gttgtctgat atgacagaag 2054161 aaaaaacgag actgctagtt tttaatttac gctatgcggc tattaatatc ggcgttgtct 2054221 tcggacctgt gcttggccta tatttcggct catcgcaatc gactacgccc tttttggtgc 2054281 ctgcagtcat ttacggacta tacggaattg tgcttgccct ccaatttaaa aaacatccat 2054341 ccttatcagc accagcccag tcccgaaata tgagcgtgcg ggaagcgttt atggtcacgc 2054401 aaaaggatta tctttttacc attgctttgg tcggcattac gctatgcacc ttcggctact 2054461 cacaattcag ttccacattc cctcagtata tggcgcagaa ccccttgatc ggcaatggaa 2054521 cgaagctgta tgggctgatg ctgacattaa acgcaatcgt tgtgttggcg acgcaatttc 2054581 ccattgtcca ttttgcaaaa cggttttcgc cgctttgttc tctgatgctc ggtaatgtga 2054641 tggttagcat cagcatggcc attttcaccg tatcacacgg tgttccatca attgtgatga 2054701 ttgtcatcac atttacaatc ggcgaagtgc ttttattctc tatgatggat ttgtatgtag 2054761 accagattgc aaaaccagga ttaaaaggca cttatttcgg ggcaatcggt ttttcacagc 2054821 tcggaaacgt catcggccct tgggtcgggg ggatatgtat agacctgttt ggcgctggcc 2054881 ggccgattta tattttttct gtcctgagcg gcattaccct gctcggcctg ccatttttag 2054941 cgttcgccta tcggcaaatg aaaatggaga ccacaaaaca ccgttcccgt ctggaaaagc 2055001 cgctttaaat aaaaaacgga agagaatgaa tctctcccgc aaacatgagg tgaagaacat 2055061 gaatataggt gatgtgatgt ttcagctgtt tgtatttatt atatttgccg ctgtcgtctt 2055121 tgcggctgtt acaggcttca agtatgcgaa aaaccgaaaa gcgcagctgg atcgcattga 2055181 gaaaaagctg aacagcctgt ccgaagatca cgattaacag cttggggcaa cgagctctac 2055241 cttaatccgg tctggatcct cacaaaagac tgcataatgc ccgtctcctc cggcaaaagg 2055301 atgcctgtct cggtacaaca cacgatagcc ttttgccgtc aatttttcag tcatctgatc 2055361 gacttgaagc ttggattcag catgaaatgc gagatggttc agaccgactc ggcatctatg 2055421 gtattccggc tctagaaatg gctctttcgc ctgcacaatc actaggtaaa aacgatcttt 2055481 cttccagctg atgcctgagc tccatttttg atactcttta taaccaagtt cttttaagaa 2055541 ccagccccaa aaccgcctag acgcctccaa atcagagaca tacagttcaa tatgatgcac 2055601 atttcatacc ctccttacca acacttcctc gaccttatgc ccgtctccct tacgcaaaat 2055661 gagatctgac ctgaatttag ttggcaaaat attttcatat aaattcggcc ggttgacact 2055721 ctcccaaatc gaggctgcca tctcgtcagc ctcctgatcg gacaagtctt taaatttatg 2055781 aaaatatgaa tcaggatttt gaaaagctgt ttcccgaagc aggcgaaaac gctctaaata 2055841 ccaagtgaaa atccggcttt cctccgcatc cacataaatc gaaaaatcaa agaaatcgga 2055901 aacaaaaata cgcgggtttt cccggtcatc ctccaaggtg ggcgactgaa gaacattaat 2055961 gccttcaata atcacaatat ccgcctgttc tacaacctcg aacacacctt cctcgcggtc 2056021 ataggttaga tgggaataca ccggggcctt tacgctgtcc tttcctgatt ttaagtcatt 2056081 caaaaattcg agcagcgcct ttacatcata gctttcagga aatccttttc ttgacatcat 2056141 atttttcttt ttcagctcgg cagtaggaaa taaaaaacca tctgtcgtga taaggctcac 2056201 ttttggacgg tcaggcaaac gcgaaagcag cttctgcaag atccgcgccg tcgtgctttt 2056261 tccgactgcg acactgccgg caatgccgat aataaacgga attttggctg aatgtgggtg 2056321 cttcaaaaaa acattgacat gcttattgcg ttcagccgca gacttgacat gtaaatgaag 2056381 caagcgaaca agcggaatat agatcgtctc cacttcttca acagatagat aatcattcaa 2056441 tccttccaca gcttttgcct cttcttcaga tacagcaatc gacaaatgcc ccccaaaacc 2056501 agaccaagac tcccgattgt gctgtgtata taaagtatgt aggttaagtt ctttattttt 2056561 cactgtttac acctgactct ctgtaggtta aaacccttac aaagattgta acggaaaacc 2056621 ttttcactgt ctgcttattt ttcatttcgt ttttttagca aatcagcacc gattcggtta 2056681 tacgcagcca tttcatcttt tggaaccatg cttcctcccg ttccccagac gacatgtacg 2056741 gcatgttcca tcttatattt ctgagcatag cgccttccct cttctgtcga aaaaagctga 2056801 accggcccga acatgccagc aagagcagag ggctctaaat atttatcttc agatacagcc 2056861 agcatatgaa gcaaagtata aagcgtattg tcctctaccg tataacagcc gctcagaagc 2056921 ggttcaatca gcttgccgac aaatcctgac ggcctcccta cggcaagtcc gtcagcagcc 2056981 gtctgattat ccaggccgat atcctggacg gagatcttct cgtgaagtcc tgaataaagc 2057041 cctaacagca tacaaggtga atgagttggt tctgcgaaaa acacatgaac atcatctccg 2057101 tataaaagct tcagcccaaa tgctacaccg cccggtcctc cgccgactcc gcacggcaga 2057161 tacacaaaca agggcgtctc aagacttggc tttatattca tacagtcaag ctgtgttttt 2057221 aatcggcttg cagcaacagc atatcctaag aacagctgac gagaatgttc atcatcaata 2057281 aaataacaga atggatcttg ttccgcctgc cgtctccctt cgttcaccgc ttcactgtaa 2057341 tctgtttcgt actccataac agtgactccc ttttggcgga ggagatcctt tttccactgc 2057401 ttagcatcgg cggacatatg cactgtcacg cgaaacccga gtgccgcgcc gatgatgccg 2057461 atgcttaaac ctagatttcc tgtcgaaccg acagcaatcg aatagcggga gaaaaacccg 2057521 gtaaaccgct cttcctgtaa gatgcggtaa tcatcggttt cctgaagcat tccttcttga 2057581 agcgcgagat tttcagcata ctttaacact tcataaatcc cgcccctcgc tttaatcgat 2057641 cctgaaatcg gaagctcatg gtcgcacttt aaaagccatc ttccgggaaa tggctgctga 2057701 tatgccgctt ccagctttcc cttcatatgc tgcacctcaa aaagcggaga ctcgatgatt 2057761 cctttagcgc ctttcgtctc aggaaacacc tcggcaatgt aaggtgcaaa ccgctgcatt 2057821 cttttttccg cttccgctat ctcggttgcc cactcatctg cacggggtaa tggcccctct 2057881 ttcttgcctg aatttgccca gaatacaggc tctgcatcaa tcagtttctg aataaacgga 2057941 tctttaagca gagcatgaag gacttctgaa tgaactgaca ttcaacaatc tctcccttcc 2058001 actatcaaaa actgccccgt gagaaacaag ccactccacc acaggcagtt ctatcattat 2058061 tttttcatga gcgcgcgtcc tgccagcttt tctacaagag ctggaaacag ctgatacagc 2058121 ttagtgccgg cattcattaa acgcggaaga ttgatctccc gctttttcgt aaaaattgca 2058181 gctgtaattt gagctgccac gtcatcagga tcaagcatcc agcggccgac atttttggcg 2058241 tagtccccgc ctttatcagc aatggaaaaa aagtccgtct gaatcgggcc cgggttgact 2058301 gttgtcacat aaatgccggt tcccgaaagc tccatccgca aagcgtttga gtaacctaac 2058361 acggcatgtt tggtcgcgga atacaggcta gacttcggtg tggcgatttt ccccgcttga 2058421 gaggcgatat tgatgatatg tccctttttt tgctcaagca tttgcggaag caccgctttt 2058481 gtacaggcga tcaggccgaa gacattcaca tcaaacatcg ctttcatgtc atccaatgta 2058541 gagtctaaaa ccgtttcaaa tataccgaag cctgcattgt taatcagtac atcaatcgag 2058601 ccgatctgat cgcggacccg ggcgatatcc tctaggcggc cgacatccag aggaaaaatc 2058661 tcacactgtc cgctccattc ctcggttatt ttccttttga tttctatcaa acgatcctcg 2058721 cgtctagccg acagcaggac atgggctcct tcagccgcgc ataagtatgc gattctttct 2058781 ccaagccctc ctgaagcgcc ggttatccaa atcctttttc ccgctatatg tttcacccat 2058841 ttcacctctt cattgtttta aagtatacgg tatttccttc ccaatatgac gtgatggctt 2058901 cttcagcctc caacacatca aggtgacctg ccgtttctga catcgttaaa aacaattcct 2058961 tttcatatac agcaggaaaa agctgctgac agacctgaaa agcggtcatc ggcttttcat 2059021 ccagcatgcg acgcacatcc tccgtcctgt tcctctgctt gtcaaaacgc ttctcaatca 2059081 gcgcttgtac actggtgata ggctcgccgt gaccaggaaa tacgattgtt ggatcaagtt 2059141 gagacagcct tcgcaatgac cgctgataat ccactaaagg ctttgacctg acgtctcccg 2059201 ctttcggcgc ttccaaaatc ggattagacg agctgtttgc cagcagtaga tcgccgccaa 2059261 gcatccttcc gcttttttca tggaacagaa caatatgcga ttcagcatgt ccaggcatct 2059321 ccaacacaga ccagccctca agcccatcta tgcccatacc ttctctgatt gattttgtca 2059381 gagatctcgt acaggaaaat gcgtacgctg atcgaatcag cttttccgcc ttccccgtat 2059441 caaatggaac gcctaattca ggcagcagct tttgaaaaaa acgtttttgc caatccataa 2059501 aggcttgatt ttggctgata taaggttcgt tgaatgtatg cccaatcact tcgatttcat 2059561 ctgaaaagac atcaagcaag cctgcatgat cagcatgatg gtgagtcagt acaacctgct 2059621 cgatatctga caatttcaca tttacagcgg caagctgctc ttgtaaggct ctggcagcct 2059681 cttttgtatt cggcccggca tcgataagtg tcagcgcatc accttttacg aggtaaacga 2059741 taacatcgcc gacagcaaac ggtgtcggga cgcggatcgc aattacatct tcagttgtca 2059801 tcctttcgct ccttgtcttc attcattatt catattttag ctttttctcg gtcttgtgtc 2059861 attattgcag aatgagaaca aacctttttg aaaaagctat tgacattagc ttgtccgcca 2059921 ttgcataatg aacaacaaac taaaacgaga accattggaa cgctatgacg aggaatagta 2059981 tacaaggcaa tggcctaaga gagcgatacc cccggctgaa aggtgttgcg gcccgcttgt 2060041 ttgtagaacc tgccctcaag tcgcggttag gaaaacctaa acgtttcccg cgttacgggg 2060101 atttgagctg agcacaattt gtgctaatga gggtggtacc gcgaaccttt tcgtccttta 2060161 cgtgatgaaa aggttttttg ttgttctaat agaaggagga tatcaatgaa aaagatagga 2060221 tttgtcggcg ccgggtcaat ggcagaagca atgatcaacg gcattttgca aagcggcatc 2060281 acaaaaccag aacatatcta tattacaaat cgctcaaatg acgagcgtct gattgaatta 2060341 aaggaaacgt acagcgtgcg tccatgcaga gataaaaatg agtttttcac tcacaccgat 2060401 atcattatcc tcgctttcaa accgaaagac gcggcggaaa gcatcgacag catccggccg 2060461 tatatcaagg accagcttgt catttcagta cttgcaggcc ttaccatcga aaccattcag 2060521 cattattttg gcagaaagct cgcggtcatt cgcgtcatgc ctaatacatc agcggcaatc 2060581 agaaaatcag caaccggatt ttccgtaagc acggaagcaa gcaagaatga tattattgcc 2060641 gcaaaagctc tattggaaac aatcggtgat gcaacactgg ttgaggagcg gcatcttgac 2060701 gctgtcactg caatcgcagg cagcggcccg gcctatgtgt atcgttatat tgaggcgatg 2060761 gaaaaagcag cacaaaaagt aggattagat aaagaaacgg caaaagcact cattttgcag 2060821 acaatggcag gggcaacaga tatgctcctc caaagcggca aacagccgga aaagctgcgt 2060881 aaagaaatca ccagtcctgg gggcactaca gaggcaggtc ttcgcgcttt acaggactcc 2060941 cgctttgaag aagcaattat tcactgtatt gaagaaacag ctaaacggag cgcagaaatc 2061001 aaagaacagt ttgccggtgc cgccttagag agacattctt agatgtaagg acaaaaacag 2061061 aaggcacagt gccttctgtt ttttattttt cccgcagcag ctggccggca gattctgatt 2061121 gctttaatag cgcggagatc gtaaatgaaa gcaaatcggg aagcacttca aaggaataag 2061181 gcatatacaa tctttccgtc catttatgcg ggtctttacc agccggaccg acatttaaaa 2061241 ctgggacata taaagcctga tttttaccgc ttggcaatga ataccctctg ttaaagagcg 2061301 gcatattgct tgtgtatgca tcaacctcct gtttttccag ctgaagataa ctcaagtccg 2061361 aaagtccggg gaagtactga acctcccgta atgcaatgcc gtatcgctca gccgcataat 2061421 gctttatctg atctgctgta tttctgatca attgatcatc ctttgaagaa acagctggat 2061481 aaagcggcgg actataaaac agaacgatga gcggcgcatc ctccttacaa agcgaagcaa 2061541 gctcagaaac aattttcgtc gaaaaatccc tgtctccaag ctcccccctg ttagcaaagg 2061601 cataatttag agcccgctct gtttccgaga tccccgcacg cttttttgca cgcgagacca 2061661 gctcatcaaa tgtcaaaaca gtgacgtccc gctcaatcgg ctgaaatggc tcaaattgtt 2061721 gaaaatcctg tgttttcttc cgaacgttcg acatgatttc ctccgccgcc tgttctgctg 2061781 ttttaagcag catctgatgc agctcactag ctgagcgttt cattgacagc acattaaata 2061841 atgtgacggc tgtatgcggt gtctggactg aatatgcctc tttcaagtcc ttttgcatta 2061901 agtttaccgg cggcggagtg acctcgccat caaccttttc gcaataatca gcattcagtt 2061961 caagcaaacg gttaatctca gataccatta aatttgcgtt tagacctgaa aacggctctc 2062021 caacatgtgt ctcaatcccc ttgcagaaaa aacccgcaag caccttgcca atgcttcctg 2062081 tataaaaata ttgctgctga tcgccgggaa atttttcaaa catcggttcg gcattcaggc 2062141 aagcggttaa tgtgatatca tgctttttct ccatctcctt caatgcagga accgcttcaa 2062201 tcatgcctct tgaattcact tcctcgtccg gaaccgttat caacagcaga ttgccctcaa 2062261 aatgcccgtt cattgccctc tccagcatcg acagttgaat acaaagcccc gctttcatat 2062321 ccatcgtccc tcttccgaac agccagtctc cgctttcggc atctcttctc acacgttccg 2062381 ggagcagctc ttttttctct aaaaaggagc tcaaaagctc agcaggcttg caagccatat 2062441 gtttaaattc gccgtaatct tctatgtcaa cgacatcaaa atgactcagc agaagcactg 2062501 tctttttgac attcttcttt ttgactagag ccgtaagaaa agatctgcca tcgtccatcg 2062561 gatgaagtgt tacatcatca gggtgctttt gaaaataggg cttgtccttc aaaataaaat 2062621 aaagatactc tgcaagcgct acctcgccct ttgaaccggt gatgctttcg tattgcacaa 2062681 gagaagttaa aagtgccagc aattcgtcct tcgtctgcca attcattgat tccgcccctc 2062741 ctatgaataa aaatgcttct atactgaaaa ataaactgat ttctcgtcta ttatacagaa 2062801 atgtttgaca aaagcggttc atttgagcag tttatatgac gggaaagaaa tgacttgata 2062861 taatcaatct ctaaaaacct tacgggaggc gaaagaaatg gccagaaaat tatttacacc 2062921 tattacaatt aaagatatga cgttaaaaaa ccgcattgtc atgtcgccaa tgtgcatgta 2062981 ttcttctcat gaaaaggacg gaaaattaac accgttccac atggcacatt acatatcgcg 2063041 cgcaatcggc caggtcggac tgattattgt agaggcgtca gcggttaacc ctcaaggacg 2063101 aatcactgac caagacttag gcatttggag cgacgagcat attgaaggct ttgcaaaact 2063161 gactgagcag gtcaaagaac aaggttcaaa aatcggcatt cagcttgccc atgccggacg 2063221 taaagctgag cttgaaggag atatcttcgc tccatcggcg attgcgtttg acgaacaatc 2063281 agcaacacct gtagaaatgt cagcagaaaa agtaaaagaa acggtccagg agttcaagca 2063341 agcggctgcc cgcgcaaaag aagccggctt tgatgtgatt gaaattcatg cggcgcacgg 2063401 atatttaatt catgaatttt tgtctccgct ttccaaccat cgaacagatg aatatggcgg 2063461 ctcacctgaa aaccgctatc gtttcttgag agagatcatt gatgaagtca aacaagtatg 2063521 ggacggtcct ttatttgtcc gtgtatctgc ttctgactac actgataaag gcttagacat 2063581 tgccgatcac atcggttttg caaaatggat gaaggagcag ggtgttgact taattgactg 2063641 cagctcaggc gcccttgttc acgcagacat taacgtattc cctggctatc aggtcagctt 2063701 cgctgagaaa atccgtgaac aggcggacat ggctactggt gccgtcggca tgattacaga 2063761 cggttcaatg gctgaagaaa ttctgcaaaa cggacgtgcc gacctcatct ttatcggcag 2063821 agagcttttg cgggatccat tttttgcaag aactgctgcg aaacagctca atacagagat 2063881 tccggcccct gttcaatacg aaagaggctg gtaatgccca taagagatat cctgtagagg 2063941 atatctcttt ttttattttt agagaaacga tcggctaagg ttctccgtct ccctagtaga 2064001 accaattaga ggagatgact ccaatgaaat cagcttggat ggaaaagaca tatacaattg 2064061 acggatgtgc gtttcataca cagcaccgga aaggatcaag cggtgtaacg attgtctttg 2064121 aggccggcta tggtacttct tctgagacgt ggaaaccatt aatggcggac attgatgatg 2064181 aatttggcat tttcacatat gatcgggcag gcataggaaa aagcgggcaa agcagagcta 2064241 aacgaacagc tgatcaacaa gtgaaagaat tggagagttt gcttaaagca gctgatgtaa 2064301 aacctcctta tttggctgtt tcacactcat acggagctgt catcaccggt ttatgggcct 2064361 gcaaaaacaa gcatgatatt atcggcatgg tccttcttga cccagcttta ggcgattgcg 2064421 ccagctttac ctttataccc gaagaaatgc acaaatcaca tacgagaaag atgatgcttg 2064481 agggcacaca tgcagagttt tcaaaaagtc tgcaggagct caaaaagcgg caagtccact 2064541 taggaaacat gcctcttctt gtgttgtcat caggagaacg gactgagaaa ttcgctgctg 2064601 aacaggagtg gcaaaacttg cacagcagca tattgtctct atctaaccaa agcggctgga 2064661 ttcaagctaa aaacagctcc cacaacatcc atcatgatga acctcatatc gttcacttgg 2064721 ctatttatga cgtatggtgc gcagcgtgcc agcaggccgc tcctctttac caggcagtca 2064781 attaacgtaa aaaaagaccg ggccgtaagg gattcccggt cttttatatt attttgtttc 2064841 acggtgaagg gtatatttct ttaaacgcgg tgaatatttt ttcagctcca aacggtctgg 2064901 attggtgcgt ttattttttg ttgtgatgta atttcggtct cccgtttcag tgcaaagcta 2064961 aagtaacatt tactctcata attaacatct ccttataaaa cgtaatgatt acgttttatt 2065021 atacaacgtc atcacaaatt gtcaaataag agctccgcct tcagcctcgc gggacgttta 2065081 cctctaagaa atcatatgcc gccacgctat tggggaaaac gtcaaccgct tctttttgaa 2065141 gctccaaaga agcatctccc tgatatcttg cgctgatatg ggttaaaatg agctgcttcg 2065201 ctcttgcttc tttcgctgtt acagccgctt gttccgttgt actgtgataa taatcataag 2065261 caagtttacg gtcttcctta gcaaaggttg cttcatgaac aagcacatca caatccctcg 2065321 caagctcttt tagtttgtca cttactctcg tatcaccgga gaacacaaca gatcttccct 2065381 ttttaggagg ctccagaaaa tcattcccat tgatgattcg tccgtcttca agcgttaccg 2065441 tttcgccttt tttgattttc tgatatacag gtccgggcgg gatgttcatt tcttttaata 2065501 cgtcagcctt caaggaaccc ggtacgtctt tttcctgcac acggtacccg aaggcttcca 2065561 ctccatgaat aacagatacc gctgtgacaa taaactgatc gtcctcaaac acgattcctt 2065621 cttcaatttc ctggatcgca agcggatatg tcaaatgggt tttcgtgacg gcaaggcttg 2065681 tttcaataaa cgccttgatc cctttaggtc cgtacactgt cagctcgtcc tctccgcctt 2065741 gaaaggaacg gctccccaga agccccggaa gtccgtatac atgatcgccg tgcatgtgtg 2065801 taataaagat tttctctatt ttacgaggtt taatcgttgt atgtaaaatt tgatgctgtg 2065861 tggcttcccc gcagtcaaaa agccataccg aacgcctttc ttcaagcaat tttaatgcca 2065921 ccgacgttac atttctcgcc ttggcgggga tgccggctcc cgtccctaaa aaaagtaatt 2065981 ccacgtttcc ttcctcctac tagaaccaga tacctacaag aatacaggat caagcggaaa 2066041 atgtgaatct tgcctctgaa aagaacaatc ctttcgtgct agaaacattt tttcagcatt 2066101 ctgcttaaaa aagggcttaa atgtttgctt tcgttgaatt ttagatttaa aatgaaggaa 2066161 atatacgggg tgtactaaaa taaagcttcg aataaagtga ggtactttta gtgaaaacaa 2066221 accaacaacc aaaagcagta attgtcatat tcggtgcaac tggagattta gcaaaacgaa 2066281 aattgtatcc gtctattcac cgtttatatc aaaacggaca aatcggagaa gagtttgcag 2066341 tggtaggagt tggaagaaga ccttggtcta atgaggatct tcgccaaact gttaaaacat 2066401 ccatttcctc atctgcagat aagcatatag atgatttcac gtctcatttt tactatcacc 2066461 cgtttgacgt gacaaaccct ggttcttatc aagagctaaa cgtattgctt aaccagctgg 2066521 aagatacata tcaaattcct aacaacagaa tgttctactt ggcaatggct cctgaattct 2066581 tcggaacgat tgcaaaaaca ttaaaatcag agggtgtaac agctacaacc ggctggtccc 2066641 gccttgtcat cgaaaaaccg ttcggccatg atctgccaag cgcacaggca ttgaataaag 2066701 aaatccgcga agcatttacg gaagatcaaa tttacagaat cgaccattat ctaggcaaac 2066761 aaatggttca gaacattgaa gtgattcgat ttgccaatgc gattttcgaa ccgctttgga 2066821 caaaccgcta catttcaaac attcaaatca catctagcga atcactaggc gttgaagacc 2066881 gcgcaagata ttacgaaaaa tcaggcgccc ttcgcgacat ggtgcaaaac catattatgc 2066941 agatggttgc ccttcttgca atggagccgc ctatcaaatt gaacacagaa gaaatccgca 2067001 gcgagaaagt gaaggtgctg agagcactgc gtcctattgc aaaagacgaa gtggatgaat 2067061 actttgtgcg cggacaatat catgctggtg aaattgacgg tgtaccggtt cctgcttata 2067121 cagatgaaga taatgtcgct cctgactcca atacagaaac ctttgttgcc ggcaagctct 2067181 tgatcgacaa cttcagatgg gctggtgttc cattctacat cagaaccgga aaacgaatga 2067241 aagaaaagtc cacaaaaatt gtcgttcaat ttaaggacat tccgatgaac ctgtactacg 2067301 gtaatgaaaa caacatgaat ccgaacttgc ttgtcattca tattcagcct gacgaaggca 2067361 ttacgcttta cttaaatgct aaaaagcttg gcggagcagc acacgcacag ccaatcaaac 2067421 tcgattattg cagcaattgc aatgacgagt tgaacacccc tgaagcatat gaaaaactaa 2067481 ttcacgactg tcttcttggc gatgcaacaa actttgcaca ctgggatgaa gttgcccttt 2067541 cttggagctt tgtcgactct atttctgaaa catgggcagc aaacaaaacc ttatctccta 2067601 actacgaatc aggctcaatg ggaccgaaag aatctgatga tcttttggtg aaagacggct 2067661 tacactggtg gaacatataa taagaagaaa aaagccgaaa atgtttacaa gcattttcgg 2067721 cttttttacg ctgaacaaag gtataacaat ctccttaata acaaaacccc caaagcttaa 2067781 gagcttcggg ggtttctatt gattacttca tccattcagt atggaagatg ccttctttgt 2067841 cagtacgctc ataagtatga gcgccaaagt agtcgcgctg tgcttggatt aagtttgcag 2067901 gcagtacggc tgtgcggtag ctgtcatagt aggctaatgc gcttgagaat gatggcaccg 2067961 gcacaccttg ggcaactgca agtgaaatca cttggcgaag cgctccttga tagctttcta 2068021 caatattctt gaaatagctg tcaagaagca ggttgtcaag ctcaggctcg cgatcgtaag 2068081 cttctttgat cttctgaagg aatgccgcgc gaatgatgca accaccgcgg aagatcatag 2068141 cgatttcacc atatttcaga tcccagttgt attcttcaga agcagctttc atttgggcaa 2068201 atccttgcgc gtatgaacag attttactca tgaacaacgc ttttctgacc gcttcaatca 2068261 gctcttcttt attttctgta acaggcttca cttctggtcc tgaaagaagt ccgctcgctt 2068321 ttacacgctc ttccttcata gctgagataa agcgtgcgaa tacagattca gtaataatcg 2068381 gaagcggaac gcctaagtca agtgcgcttt ggcttgtcca ttttcctgtt cctttttggc 2068441 ctgctttatc aagaatcaca tcaacaagcg gtttgcctgt ttcttcgtct ttttttgtga 2068501 agatgtcagc cgtaatctca atcaggtagc tatcaagctc acctttattc cattcagcga 2068561 aaacttcatg aagctcatca gcagaaaggc ccagcacctg tttcagaatg aaatatgatt 2068621 cagagatcag ctgcatatct ccgtattcaa ttccgttgtg caccattttt acgtaatggc 2068681 cggcgccgtc cggaccgata tatgtcgtac aaggttctcc gtcaactttt gcagaaatgg 2068741 cttcaagaat cggttttaca agctcatgtg cttctttttg tccgccaggc atgatagaag 2068801 gtcctttaag cgctccttct tctccgccgg aaacgcctgt tccgataaaa tgaatgccgc 2068861 tttcagcgag ttctttgtta cggcgctgtg tatctttata gtatgtatta ccgccgtcaa 2068921 ttaaaatatc atccttctct agatgaggaa gaagagattg aattgtcgca tctgttgcag 2068981 ttcccgcttt aaccattaat aagattttgc gcggtgtttc caaggattgg acaaattctt 2069041 caatgctgta agtgccaaca acattttttc cttttgcctc ctgtaaaaac tcctcagttt 2069101 tactgcttga tctgttgtaa acagaaacag aaaatccccg gctttcgata tttaaagcca 2069161 gatttttacc catgaccgca agtccgataa cgccgatttg ttgttttgac atattctaac 2069221 gtcccttctg caaacgttta atcattttaa aatttaaatt aaaataaaat gatatttata 2069281 ataaagaaat taccatacat tcaccctttt tttcaagcga ttcagctttt cttttcatct 2069341 tgaaaaaaat ctttattaaa gcttgttccc tttgttttgc tctcctcttt ttttaacgtt 2069401 gccccttttc tgatcagttt ggtaccgtac tttttattca gcttttccat catctgctga 2069461 atgggctcat ccttcgcatc ttcattaaag ctgaacaaat cgagctgttt ataggcctgc 2069521 tctttttcta ctaaatccgt tccggtaatg ccaagcagcc tgacaggatt tttattccaa 2069581 tgtttaaaaa agaggtgctc cgcttctttc aaaatgtcat ttttttgatc aatcgggttt 2069641 ctcagcgtag tgcttcttgt gatggttctc caatccgcat atctaatcat aataaaaagc 2069701 ttcgaagcca tgacttcctt gcgctgtaaa cggtcactca cagaagcggc aagctttcta 2069761 aaaacgccta acagctcttc ttcatcactg gaatcatggg aaagtgtcga tgagttgccg 2069821 acgcttttaa attcgtaaat gcgctccggg tcaaccggcg catggtgaat gccatttgct 2069881 ttatttttaa ggcgcggacc gttgatgcca agcaggcgct tcagcgagtg ttcatcagct 2069941 gcagctagct ctccgattgt atggatgccg agtcccttca gtttttccgc tgtctttttg 2070001 ccgactccgt gcatctctcc aacaggaagc ggccacagga tatcgggcac ttgcctcttt 2070061 cttaagatcg taattccaag cggttttttc atatcagacg ccatcttagc gagaaattta 2070121 ttcggtgcaa tccctatgct tgacgggagc agcagctctt tttgcagcct gctttggatt 2070181 tcttttgccg tctctagagc gcggctgctg tatggtgtat cggtcatgtc catatagcct 2070241 tcgtcgatgg agacaggctc cactaggtca gtatattcac gaagaatggt aaacatcgct 2070301 cgtgaagagt ttctatagcg gtcaaagttc ggcggaagaa cgatgagctc aggacaatgg 2070361 cgcttcgctt gccaaaccgg catcgttgtt ttgacgccgc gcgctcttgc ttcgtagctg 2070421 catgttacca caatgccctt tcgctccttt acgtttccgg caactgcgac cggctttccc 2070481 cggagagccg gatcatatgc catttcaacc gacgcataaa agctattcat atcaatatgg 2070541 aaaataattc ggctctttcc cggcataaac aaatctcctt ttcggtcatt agacaacagc 2070601 ttgtacatat agtaaaatga agctattgaa tggatgtgat gacaatgttt gtggaatcga 2070661 taaatgacgt tttattctta gtcgattttt tcacaattat tcttcctgct ctaacggcaa 2070721 tcgggattgc attcctctta cgggagtgcc gtgcgggcga gcaatggaaa tcaaaacgaa 2070781 cagatgaaca tcagacggtc tttcacatta accgaacaga ctttcttatt attatatatc 2070841 atcgcattac aacttggata cgtaaagtct tccgcatgaa ttcgcctgtg aacgatgagg 2070901 aagacgccgg ttctcttctt ttataaaccg catttataaa aaggaggaga acaaaattgt 2070961 taaaaacata tcaaaaactt ttggctatgg gtatcttttt gatcgtatta tgctcgggca 2071021 atgctgcatt tgcagcgact aatcaggtgg gaggcctcag caacgtaggt tttttccacg 2071081 attatttaat cgaaccgttt tccgctctgc ttaagggtgt tgccgggctg tttcacggag 2071141 aatacggact ctctattatc ctcgtaacca ttattgtgcg tatagttgta ttgcctttgt 2071201 ttgtcaatca gttcaaaaaa cagcgcatct tccaagagaa aatggccgtt attaaacctc 2071261 aggttgacag tatccaggtt aagttgaaaa agacgaagga cccggaaaag caaaaagagc 2071321 tgcaaatgga aatgatgaag ctgtatcagg agcataatat caacccgctt gcgatgggct 2071381 gtcttccaat gctgattcag tctccgatta tgattgggct ttattacgcg attcgctcaa 2071441 cacctgaaat tgcgtcacac tcgtttctat ggttcagttt agggcaatct gatattctca 2071501 tgtcccttag tgcagggatt atgtattttg tccaagccta tatcgctcaa aaactgagcg 2071561 cgaaatattc cgctgtcccg caaaaccctg cagcgcagca atccgcaaaa ttgatggtgt 2071621 tcatcttccc tgtgatgatg acgattttct cgcttaatgt gccggcagcc cttccgctgt 2071681 actggtttac aagcggactg tttttgacag tgcaaaacat cgtccttcag atgacgcatc 2071741 ataaaagtaa aaaaacagcc gctcttactg agtcggtgaa ataaaaaagc aaccccgtgc 2071801 aaaaagccgg ggttgttttt tgttacttgc aaagtaccgc gccaaacagt cttgtttatc 2071861 atggctgaag cagaaatggc catcctaaaa aatagccgta tcgtttaaaa agaaggaaat 2071921 cgggaatacc tttactcacc tccaaccgaa aggagcctat acgttgacgg aacgctttca 2071981 gcaaaaaaat atttctgtac ctgatggaat ctggatcatg agacaaacct ggaatgatgt 2072041 cttatttgct cactggcctg ttgatgtttc tatccttcgc gctttggtac cgtccgtttt 2072101 agaattagat acatataacg ggcaagcttg gatcagcatg cttcccttta tgctcacgaa 2072161 cctgagggcg cgttatctcc ctgtcattcc cggtgcgcgt gcatttcctg agcttaacct 2072221 ccgcacctat gtcacgtata aaggcaagcc cggcatttat ttttttagct tagatgccga 2072281 tcatcgtctg gcggtccttg gcgctcgcac attctttcat ctgccttatt tttacgcgga 2072341 tatgaagtcc gaaaaaaacg gtgatgccat tgactatgtc agcaagcgga aaaatgacaa 2072401 agaagcagca ttccacgccg cataccggcc aatttcagcg ccttttacag cagaaaagga 2072461 ttcgctcgat tactggctga cagaacgata caggctctac accacttatc gcaataagct 2072521 ctattacgaa gacatccatc atcatccgtg gctgctgcaa aacgccgaag cagaaatttc 2072581 agtcaatacg gtgactgatg ctcacggtat tacattgccg gagtcagacc ccttgcttca 2072641 ttatgctaaa aaacaggatg tgttattttg gccgcttagg aaatggagct aaaaaaaccc 2072701 gatgcgggaa atcgcactcg ggttttcttt ttttattttg ccgcctcttc aataatggca 2072761 acaaccattt ctgccgtttt aacgagctct tcgatcggca ttttttcatt ttttgtatgg 2072821 atttgctcat aaccgacagc aagattgacc gtcgggatgc catgaccagc gattacgttc 2072881 gcgtcgcttc cgccgccgct cgtttgcagc tcgcttggac gtccgatttt agcagccgct 2072941 tttttcgcga tttcaacaac ttggtcgccg tcttgatatt taaagcccgg atacataacc 2073001 tcaatttcga cttctgcgcg tccgcccata tcagcagctg cctcttcaaa agcagctttc 2073061 attttttgaa cctgagcttc cattttctca ggaactaaag agcgcgcttc agcaagaata 2073121 tgaacttcgt cgcacacaat gtttgtttgt gtgccgcctt caaaccggcc gatattagct 2073181 gttgtttctt catcgatacg gcccaatggc atttttgaga tggctttgct agcgattgta 2073241 atcgctgaaa tgcctttttc aggttcaacc ccggcgtgag cggttttccc gaaaattgcc 2073301 gctcttacct tcgcctgtgt cggcgcggcc acaatgatat ttccgacttt tccgtctgaa 2073361 tcaagagcat agccgtagga tgcagtgatc atagaacggt caagcgcctt cgctccgatc 2073421 agacccgatt cttcccctac tgtgatgatg aattcaatcg tgccgtgttc aatattttct 2073481 tctttcagca ccttaatcgc ctcaaacatt gcagccaatc ccgctttatc atcagcacct 2073541 aaaatcgtcg tgccgtcagt tttgacgtaa ccgttctcta caactggttt tacgccgttt 2073601 ccgggtacaa ctgtgtccat atgagatgta aaatagatcg tatctgtttg ttttgtccct 2073661 tttagcgtgc aaatcaggtt accggctccg tggcccgtga tatccattgt atcgtcttct 2073721 ttaacgtcca cacctaaatc agaaaatttt cgtttcagca ctttgcagat ttcagcttcg 2073781 tgctttgttt ctgagtcaat ttggacaagc tctaaaaatt cttccagcag gcgtttttca 2073841 ttcaccattt gtaagtccct ccatattaaa gcggtatgtt accgtgcttt tttttcggtc 2073901 tctcttctgt cttatgtgta agcatatgaa aagcttgaat cagtcttccc cttgattctt 2073961 ccggcaaaat gatgtcatcg accattccac aagcggccgc tttgtatggg ccggcgtttt 2074021 gctttttgta ttcagcagtt ttttcgcgtt tcgtcttttg cgggtcagct gaagctttga 2074081 tttccttttc atacaaaatc gatgccgcac cttctggacc catcactgcg atttcagcat 2074141 tcggccatgc aaacacaagg tccgctccga tcgctttgct gttcatggcc acataggcgc 2074201 cgccgtacgc ttttctaatg atgagtgtga cttttgggac agtcgcttca gcataagcaa 2074261 acaataattt tgctccatgc ctgatgattc cgttgtgctc ttgctgaata cccggcagaa 2074321 accccgggac atcttcgaca gtcaacagcg ggatatcaaa tgcgtcacaa aaacggatga 2074381 accttgctgc tttatcagca gcgtcaatcg tcaggcttcc cgccagatgc ttcggctggc 2074441 tcgccacgat gccgattgct ttttcaccca gccttgcaaa cccaatgaca atgttcttcg 2074501 caaaaaatgg ctgaatctca aaaaaagact gcgggtcagc cagctcccta atcaccttcc 2074561 gaacatcata aggctttgtc gtatcagcag ggacaagacg gtttaataac ggtctggacg 2074621 cctctttctc tggcttcggc tctgttgtcc ggccattcag cggcaaataa gacagtagtt 2074681 ttctcacccc tgtcagaacc tccttctccg tatgcccgga aaagtgggcg tttccgctga 2074741 cggcattatg tatccccgct ccgcctaagc tctccgcatc aacctgttcc cctgtcactt 2074801 tttcaatcac cttcgggccg gtaataaaca tccggccagt ctgttcagcc ataaatataa 2074861 aatctgtgag tgccggagaa tatacagcgc ctccagcgca cggccctaaa ataaccgata 2074921 tttgcggaat gactccggaa tataagacgt ttcggtaaaa tatgtgaccg tatccatcta 2074981 atgataacac accctcttga attctcgcac cacctgagtc attcagcccg ataatcggcg 2075041 ccttattttt tgctgccaga tccatcaaag cgcagatttt cctggcatgg gtttcgccaa 2075101 gcgcccctcc gtacactgtg aagtcttgcg caaatacata aactgagcga ccgtcaattg 2075161 tgccgtaccc tgtcacgacc ccatccccta acatgcgctg ttctcttgtt aacacttgac 2075221 tttccatgaa ggggtgtaat tcgataaagc tgtcctgatc tagaagaaat atgatccttt 2075281 cccgagcagt gagcttgccc ttttgccgct gctgagccag cttttcccgt cctccgcctt 2075341 cttctgcctg cttgcgtttc gtgtaaaaat gatccatgtg ctcattcatg ctcattgtgt 2075401 tggtctcctt tcggttcaca aagctctaca agaacaccgt ttgtttcccg aggggaaata 2075461 aacgcgatct ttttcccgtt cgctccctgt cttggaaacc tgtcaatcaa ttgaacatgc 2075521 tgatcagaca atgcttgaag ctgttcagat aggcagttgc acaaaaacgc aatatgatgc 2075581 agtccctgcc ctttcttctc caaaaataaa tggacggggc tgtcagctgt caacggctct 2075641 atcagctcaa gtttgacgct accagcttga aaaaaagcaa cattcacctt ttgctcttca 2075701 accgtttctt gatgaagaaa tgcaagcccc aatacatttt cataaaagct tcttgcatct 2075761 tttatcgaaa aaacggctat cccgatatgg tcaagcctgt tcattttcat ccctgctttc 2075821 gctaatagat atcgcttgtc cgcccattca aaacacgcta aaatatagac agattgttta 2075881 aggagtgaaa atcatgtctc aaaaactgat gaaaagcgtt ttgatcgtga ttttgggagt 2075941 ttttattctt tcaactgtac tctcaggaat cgtcatgttt ctataacgat aaaaaagcag 2076001 gcgccttatt caatgggaat atcctgcttt tttatcagag ctttatgctc gatggcaatc 2076061 tcctcaaaag agcggttgtc gtccgtgatc agcactctcg ttcctactgg tatcgtttga 2076121 aacaaatgaa caacctcatc gttatgcata cgtatacagc cgttagacac aaattttcct 2076181 actgattcct ctcggtttgt cccatgaatt ccataaatcc gcccgtccgt tcctttcgcg 2076241 tcaaatccga tccatcttgc cccaagcggg ttatcaggag atcccccttc aatatttttc 2076301 tttctgtagt aaggattttc cgcttttacc gttaccgaaa actctccttc aggcgtcaaa 2076361 tcatctgttt ttccagtcgc cacactatac acgccttcta ctttgttgtc gaggataaca 2076421 gcaagttcat ttgttcgctt gttgacaata acatacggat cacccggcag cggattttcg 2076481 ccgagcggcc aaatcggtga aatcatcatg aaaatcgaac ataagaaaaa acgcataagc 2076541 tcctcctttt tcattaggtt gaccaatgaa ggaagagctc atgcgaatca tccgagtgat 2076601 ttttgcgctt ttattccttt aaaataactt ttaatcacta aatattgttc catttcgccg 2076661 agaagatgga agagagcggc cctcgcttca aattcctctc tagtcgcagg aagcggcatc 2076721 tcctcaaatt cttttctcat gtcagcaagt cttttcagaa atttgtatgc tgtattccca 2076781 gggtgtatcg cctcccgcaa atcatgaata aattcagcga tcatttttcc ctgatctacc 2076841 gtgatggaga tcgatgtcac tttagggaga aggcgttcga taatttcaaa ttgcttttct 2076901 ctcattttaa aataatgata atgcagattt tcataacgca aaatgtggtt ttgcacatct 2076961 cgatatgcca ggtttttagc ctccgtaatg agctggtgcg tttccggaat ttcttttcct 2077021 gaccaatctt gctcaccagt taacaaatac cgttcgattt ctgcaaaaat gacagcaaag 2077081 ttatcctcta tctttttgcg gtaggcaatc agtttccggt caagactagg catatacaag 2077141 ttcatcaata gagcgacgcc gatgccaacc gtaatcagct gaacttcatt ccagatgaaa 2077201 gtaggcgtaa tgccgccgga catgtataaa tgaaggataa taacagaact ggtgacgata 2077261 ccctcgttaa tttttaacag aaccgttatc ggaatgaata tcaaaagaag cgctccgatc 2077321 acaaacgggt ggtagccaat aagctcgaaa aagagataag aaaaagcaat tgccagacag 2077381 catgccgaaa agcgggccca tgaggcctga agcgaccgtt tttgtgtgat ttgtatgcac 2077441 aaaatggtga tgattcctgc tgatgcgaag ttttgcaaat gcaataactg gcttatataa 2077501 atagccaaag ctgttccaag cgcggtcttt attgtgcggt aaccaatttt aaacatgtcg 2077561 gactccattt ctatttgttt cttcaataaa aaagaagagg cggccagcct tcttcttttt 2077621 tatattctat aatattttct ctaaaaagtc ctgcgctctt ttggattttg gcgacataaa 2077681 aaattccttc ggattgccgt cttcgacaat cattccttgg tccataaaca gcacacggtc 2077741 tgccacttct tttgcgaagc ccatttcatg tgtgacaatc accatggtca tgccggtttc 2077801 gaccagctct ttcatcacct gtagcacttc tttgaccatc tctggatcaa gggcggaggt 2077861 cggctcgtca aacagcatga tgtccggatt catcgcaaga gccctggcaa tcgcgacacg 2077921 ctgtttttgt ccgccagaca aacggtttgg atagtcattt cgcttttcaa acaaaccgac 2077981 tttgcggagc aggtcctcag ctttctcctg tgcagcctgt tttgattctt tttttacatt 2078041 gacaggcgcg tacatgatgt tttcgagaac cgttttgtgc ggaaagagat gaaaatgctg 2078101 aaaaaccatc ccgatgtttt cccggacctt taatgtgttg gttttcggct tcgtaatctc 2078161 tgtgtctttt attgtaatgg ttccgccgtt aggcttttcc aacaggttta aacagcgtaa 2078221 gaacgttgat ttgcctgagc ctgaaggacc gatcacggca acaacctcac cctcagcgat 2078281 tgttgttgaa atgtttttta atacttcgtg tttcccaaat gattttgaca gcttttcaac 2078341 cttaatcatt ggatttcagc ttcctttcta cagccttgcc gataaacgtt aaaatcagga 2078401 caagcacata ataaatcaat cccgcgataa tgagcggctc aaggtaattg taagtggcgg 2078461 cgccagcttg atatgcgcgt ctcatgacat caccaagccc gatgacggtg acgatcgccg 2078521 attcttttgt taacgtaatt aattcattca caattgcagg tgatatattt ttgaaggcct 2078581 gcggcagcag cagatccttc atcatttttc catacgggac accgagtgca acagcagctt 2078641 ctttttgccc tttatcaatg gcattgattc cggctctgat aatttccgat acataagcgg 2078701 cggaattcaa agacaatgcg acaaccgcag cccaaaactg gtcaatttga aatccgagca 2078761 gctgaggaag gccaaaatag acaatcataa gctgcagcac taaaggcgtg cctcggaaca 2078821 ctgatgtata aaaatcagcg atccagataa acgggcggaa tgtgctgatc ttgcataagc 2078881 ttagcacaat accgagtata agtccgataa tagcagatac aacaacaatt tttaatgtaa 2078941 ttgccaagcc ttctaatata aaaggaattt gggggatcgt tgctgaaaaa tccaaattca 2079001 tagcctttgt ctccttttct tacaggaaaa aagtttccta ttcaataaaa aggctcaacg 2079061 aaaaagttga gccgcttttt tttacttctc gccagtgaac cattttttct tcaatttctc 2079121 aagctctccg ttatcttcca tttccttgag cgctttattg aatttgtctg tcagttcact 2079181 gtcctttctg aaagcaattg ctgaaccggc ttcttccgct ttcgcatcag gaatcacaaa 2079241 gccttgcagg tcatcatttg atttgaaata cccttctgca acaatgtctt caataatcgc 2079301 ggcatcgaag cggtcagatt tgatttcctg caccaaatca gaaattctgt tgcggtcttc 2079361 tgttttaaaa ccatattccg gagaaagctc tttccccttc tcttcctgaa tagagccaag 2079421 ctgaacgcca actgtttttc ctttcaggtc tttcaaagat tgaatgccgc tgtctttttt 2079481 gctgacaatc atatggttcg ctgtgtaata cacatcggaa aaatcaactt gttttttacg 2079541 ctcaggcgtt ggtgtcattc ctgacagaac gagatccacc tgttttgatt taagcgctgt 2079601 aattaagctg ttgaagtcca tatcctgcac ttcaatttca tagcctgcct tctttgccag 2079661 agcttttgcc agctctacat caaagccgac aatattatct ccttctttat attcaaacgg 2079721 tttgtaatcc gccgaagtac ccataattaa ttttttcttt ccgctttctg aacctgaatt 2079781 gcttgagccg cacgcagtta atgcaaaggt gatgcaagca gccacaagta ataagagcca 2079841 ttttttcatg atccatttcc cccgtattca ttacttttgg tgtatttgaa tatttattcg 2079901 ttaatttgta ttttaaacag tttctcattt ttatgcaata ctatttttaa aaattatctt 2079961 taggcttatc tttccagtga tctcttctga tattactaga taaaaattaa atcgctgtac 2080021 aatccgattg aataatccct taatatttat tcatatatcc ttggaaattt atgcacaaaa 2080081 aaacccgggc tgctttgagc atccgggttg ttcgtcttat acttcttcac aatattcttc 2080141 aaaggcttcc tgcagctttg ccactacagc catcggctca tggccttcaa tttcatgacg 2080201 ctctaccatt ttcatgatct ttccgtcttt caaaatcgca aaggacggag aagatggtgg 2080261 ataaccttca aaatagtcac gcgcacgcgc tgtcgcttct ttatcctgtc cggcaaaaac 2080321 ggtgacgagc tgatcaggtc ttttatcata gtgaacggaa tggtaggctg ccggtcttgc 2080381 aattcctccg gcgcatccgc aaacagagtt taccatgacg agcgtcgttc cttttttcgt 2080441 aagtgcctca tccacctctt cggctgtttt aagctcggtg tatccggcag ctgttatttc 2080501 ttgtctcgct tggcggacaa tatcattcat aaataaatta aagtccatgt tcaatgaaga 2080561 cctctccttt ttcatcatct gttcttatga tagcaaggaa acgtccatat cggcaaatga 2080621 ctttgcttcg ccgtgcactt tttttgctct tcgtttactg cttacagaaa aaggggatta 2080681 tataaccaga agtaaaataa aggagcagtt gtatatgagc caccggaaag cgttactgat 2080741 tcataacgga aatgccggca acaaaaatat agaaaaagca cttggtgctg tggtgccggt 2080801 tttatctcac catttagatg aggtgattat taaacagaca aagaaaaagg atgatgcgta 2080861 tcatttttgc cgatccattg atgattctgt cgacaccgtc ttcattctcg gcggcgacgg 2080921 cacgatccat caatgcataa atgctatcag cgctctagaa agaaaacccg ctgtcggaat 2080981 tttgcccggc ggcacgtgca acgacttttc aagagtgctt ggcatccctc aaaatcttgc 2081041 aaaggccgcg gaagcactta tggcgggaaa aaaaaccagc gtagacgtat gtcagatgaa 2081101 tgaccgttat tttttgaatt tctgggggat cggcttaatt gcagaaacgt cgaatcaaat 2081161 caacgaaacg gaaaaagcat tattgggaaa aatcagctat tttacaagtg ccttgcgaac 2081221 cgtctcatct gctgcatcgt ttccgatgac attaaaaatt gatggagaag aaattaaaga 2081281 agaagccgtt atgctgcttg tgatgaatgg ccaatacatt ggaacgaatc gaattcctct 2081341 gcccgatgcc agtattgaag acggcttact tgatgttctc atatgccgca ataccaacct 2081401 caccgcgctg cgggagctga tgagcatgga acaaggctca attgatcgtt ttactggaga 2081461 gttgtcctat gtccaggctt cccgtatcga gattgaaaca gacactgcca aaaaggcgga 2081521 tatggatgga gaagtttata cacatacacc cgcagtcatt caggtcctgc cacagcatat 2081581 cgacatgctt gttcccgcaa atgaataact gtcataaggc tttagaaaga ttttgcaaat 2081641 ccgttgactc tcccctagga ggaggtctta cagtataagg gatacacact tgaaaaaggg 2081701 gaagtcatat ggagaagaaa aatattacct taactatatt attaaccaat ttatttattg 2081761 cttttttggg gatcgggctt gtgattccag taacgccgac cattatgaat gaattgcatt 2081821 tatcggggac cgcggtcggc tatatggttg cctgcttcgc tattacacag ctcattgtct 2081881 caccaatagc cggacgatgg gttgatcgct tcgggcgcaa gatcatgatc gtaatcggcc 2081941 tgttgttctt tagtgtgtcg gagtttttgt tcggcattgg aaaaacagtt gagatgttat 2082001 ttatctcccg tatgctgggc ggtatcagcg cagccttcat tatgcccggg gtcacggctt 2082061 ttattgcaga tatcacgacc attaaaacac ggccaaaagc gctcggttat atgtcagccg 2082121 ctatttcaac aggatttatt atcggccccg gcatcggggg atttttagca gaagtccatt 2082181 cccggctgcc ttttttcttt gcggcagctt ttgcactgtt agcagccatt ttatcaatcc 2082241 tcacgctgcg cgagccggaa cgaaaccctg aaaatcagga aataaaagga cagaagacag 2082301 gctttaaacg aatttttgcc cccatgtatt tcatagcttt tctcattatc ttaatttcgt 2082361 cttttggttt agcatcattt gaatctttat ttgcattatt cgtggatcat aaattcggat 2082421 ttacggccag cgacattgcc attatgatta caggaggagc gattgttggc gccattacgc 2082481 aagtcgtctt attcgaccgc ttcacaagat ggtttggcga aattcattta attcggtaca 2082541 gcttaattct ctcgacgagt ctggtattct tgctgacaac ggtacattca tatgttgcga 2082601 ttctgctggt gacagtcacc gtatttgtcg gatttgatct catgcggcct gcggtaacga 2082661 cttacctgtc aaagattgcg ggaaatgaac aggggtttgc cggcggtatg aattcaatgt 2082721 ttacaagtat cggcaatgta ttcgggccta ttatcggcgg aatgctgttc gatatagatg 2082781 taaactatcc tttctacttt gcaacggtca ccttagccat agggattgca ctgaccattg 2082841 cttggaaagc gcctgcacat cttaaagcca gcacgtgata agaagcgcat tctttgtgta 2082901 ctgcaaagaa tgcgcttctt ctttatactg atgatagaag gagtgatggc atgaaggaat 2082961 cgtattactc aattggggaa gtatcaaaac tggcaaacgt gtcgataaaa gcgctccgtt 2083021 attacgataa aattgattta tttaaaccag cctacgtcga cccggatacc agctaccgct 2083081 attatacaga ttctcagctc attcatctgg atttgatcaa atcattgaaa tatatcggca 2083141 cacctttaga agagatgaaa aaagcacagg acttagagat ggaagaactg tttgcttttt 2083201 atacagagca ggagaggcaa atcagggaga aattagactt tttatcagcc ctggagcaaa 2083261 ccatttcatt ggtgaaaaag cggatgaaac ggcagatgga atatcccgcg ctcggtgagg 2083321 tgtttgtttt agatgaagaa gaaatacgga tcattcagac agaggcagaa ggaatcgggc 2083381 ctgaaaacgt gctcaacgcc tcctacagca aattaaaaaa atttatcgag tcagcagatg 2083441 gatttacgaa caatagctac ggcgctactt tctcttttca gccctacacc agcattgatg 2083501 aaatgactta ccgtcatatt ttcacacctg tattgacgaa taaacagatt tcatcaatta 2083561 cgccggatat ggaaatcaca acgatcccta aagggaggta tgcgtgtatc gcgtataatt 2083621 tttcgcctga acattatttt ctcaacttac agaagcttat caaatatatc gcggaccgcc 2083681 aattaacagt tgtcagtgat gtatacgagt taatcatacc gattcattac tccccgaaaa 2083741 aacaagaaga atatcgagtc gaaatgaaaa tacggatcgc tgaataataa agcatagaaa 2083801 aagagcattt tttgaaacaa aacttcaaaa aatgctcttt ttgcttattt agtaaacaga 2083861 tgtcttctcg tcaatcgatt ctaaaatttg tttcactcgt ccgaggaatc gtccgcacac 2083921 gagaccgtca agcactctgt gatctaatga caggcacaga ttaaccatgt ctctgacagc 2083981 aatcatgcca ttgtccatga caaccgggcg tttgacgatg gattctactt gaagaatcgc 2084041 agcctgaggg tagttgataa tgcccatcga ctgaacagac ccgaacgaac ctgtgttgtt 2084101 gacggtaaac gtgcctccct gcatgtcatc tgcagtgagt tttccgtctc ttactttttt 2084161 agctaggccg gtaatgtctt tcgcaatgcc tttaattgtt ttttcatcag cgtttttaat 2084221 caccggaaca aataaagaat cctctgtggc aactgcaatt gaaatattga tatccttttt 2084281 ctgaataatt ttgtcccccg cccacatgct attcatttgc gggaattctt ttaacgcctg 2084341 agcgaccgct tttacaaaaa aggcgaagaa cgttaaatta aagccttctg tcttcttaaa 2084401 agaatctttt atactgttgc gatatgcaac catatttgtg acgtcgactt ccatcatcgt 2084461 ccaagcatgc ggaatttctg ttttgcttcg cttcatattg gaagcaattg cttttcttac 2084521 acctgtgaca gggatttctt tatcaccggc tgcagacgca ggatatgacg tctcttcttt 2084581 tggctcaggt tttgatgcag acttcggtgc aggagctgct gttttcagct cctcaggatt 2084641 ctgttcttgc acgccgcctg tttcaattaa gcgctgaata tcttttcgtg tgatgcgccc 2084701 gccggcacca gttcctgtca cttgatcgag gtcaatgccg tgctctccgg ccaaacggag 2084761 aacagctggc gagtagcgct ttttattggg ctgatcggct gctccagcac tttttgcaac 2084821 agggttctca gcggcttctg atgctgctgg ctgttcttgt ttttgttcag ccggattcgc 2084881 gccttctgtt tcaattttgc aaatcatttc tccgacttgc agggtttggc cttcttctcc 2084941 cacaagctct gttatcgtac cagtaaaaga agacggaacc tctgcattta ccttatctgt 2085001 catgacttcc gcgatcggat cgtatttgtt cactttatca ccgggggcga caagccattt 2085061 gctgatcgtc ccctctgtta cgctttctcc aagctgcggc atcgtcattt gttcaattgc 2085121 catgattgta tcctccctta cgtctttaaa actccgctaa ttctctcatc gccgcttcca 2085181 ctttatcagg gttgaccata aagtattttt ccattgtcgg cgcataaggc atagccggaa 2085241 tatcaggacc tgcaagccgt ttgatcggcg cgtctaagtc gaacagacaa tgctcggata 2085301 taattgcggc tacttcgctc atgatgctgc cttcttttgt atcttctgtg accaaaagaa 2085361 cctttccagt tttggacgca gcttcgatga tggcttcttt atcaagcggg taaactgttc 2085421 ttaaatccac cacatgcgct gaaatgccat ctttttcgag acgttctgca gcttgtaagg 2085481 cgaagtggac acacaggccg tatgtgatca ctgtgatgtc gtcgccttcc ctttttacgt 2085541 ccgccttgcc gattggcagg acataatcat cagccggaac ctcgcccttt atcagacggt 2085601 atgcccgctt gtgctcaaaa aacagcacgg ggtcttcgtc acgaactgcg gcttttaaga 2085661 gccctttcgc gtcatatggt gttgatggca tgacaatttt cagtccgggc tggttggcga 2085721 aaattgcttc gactgattga gaatgataca gggctccgtg cacgcctccg ccgtatggcg 2085781 ctctgacgac aatcggacag ctccagtcat tgttgctgcg gtagcggatt ttagccgctt 2085841 cagaaataat ttggttgact gccggcataa tgaaatcagc aaactgcatt tcagcaatcg 2085901 gtctcattcc gtacattgcc gctccgatac cgactcctgc gattgcagat tcagcaagcg 2085961 gcgtatccat aacgcgctct tccccaaatt gttcatagag tcccgctgtc gctttaaaca 2086021 caccgccttt tcttcctaca tcttccccaa ggacgaaaac gcgagaatct cgttccattt 2086081 cttctttcat cgccaaattg attgcatcaa tatatgacat tactgacatt tgttcttcct 2086141 ccctacttcg cataaacata atcaagcgct gactcaggag ctgcatatgg ggcgttctcc 2086201 gcttcatccg tcgcttcatt tacgattgcc ataatttcat ccagcatggt ttgttctatc 2086261 tcatcggaca gcaggcctgt ttcctttaag taagcttgat aagtaagcag gggatcactt 2086321 tttttcgctt cctctacttc ttcacggcct ctgtagctgc tgtcatcgtc atcactggaa 2086381 tgtggtgtaa ggcggtaaga aatcgtttca attaatgtcg ggccttctcc tctgcgtgcc 2086441 ctttcgcgtg cttctttaac cgcttgataa acttccagcg gatcatttcc attcacagtt 2086501 acgccaggca tcccatagcc tatggcacgg tcggaaatgt tctcacatgc gacttgctta 2086561 tcgtaaggca ctgagattgc gtatttgttg ttttcacaca tgaaaataac cggcagctta 2086621 tggacagcgg caaagtttgc cccttcatgg aaatcgcctt ggtttgaaga cccttccccg 2086681 aatgtaacaa aggctgcgat atcctttttc tccatacgtc ccgcaagcgc aataccgact 2086741 gcgtgcggca cttgcgttgt aaccggagat gatcccgtca caatgcggtt tttcttttgt 2086801 ccgaaatgtc ccggcatctg gcggcctcct gagttcggat ctgctgcttt tgcaaacccg 2086861 gacatcatta agtcctttgc tgtcatgcca aacgcgagca cgacacccat gtctctgtag 2086921 tacggcaata cataatccat ttcacggtca agtgcgaaag ccgctcctac ctgtgctgct 2086981 tcctgtcctt gacaagagat tacaaatgga attttgccag aacggtttaa cagccacatt 2087041 ctttcatcga tttttcttgc taacagcatg gttctataca tatcaacggc ttcctgatca 2087101 gtcagcccta gtgcttgatg tcggtttgta ctcattcaag cccctccttt atgcttttaa 2087161 aaatgaatgg ctttgccatc tgcggcaagc gcagcttctc caattgcttc agaaagcgtt 2087221 ggatgcgggt gaatcgtttg cccgacctcc cacggtgttg cgtccagcac tttggcaaga 2087281 cccgcttcag aaatcatgtc ggtgacatgc gggccaatca tatgaacgcc gagaatatca 2087341 tctgtatctc ggtcagccac gattttgaca aaaccgtcgc tttcaccgta tacaagcgct 2087401 tttccaatcg ccataaatgg gaacttgccg attttgacat tatgcccgtt cgcctttgct 2087461 tcgtcttcgg ttaagccgac actggcagct tcagggcttg agtaaatgca cttcggcaca 2087521 agcgtcggat caagcggatg cggattgaga cctgcaaaat gctcaacagc aataattccc 2087581 tcatgtgaag caacgtgagc taactgcagg ccaccgatta cgtctccgat tgcataaata 2087641 tgagattcct tcgtttggca gctttcattg actgaaatca tgccattttc agtaacaata 2087701 tcggtgttct ctaggccgat gccttcgata tttgcctgtc tgccgatgga aacaagcatt 2087761 ttctcagcag aataggtaac ggtttctccg tctttttccg cttgtatgct gatatcgtct 2087821 gatgtttttg tcattgtgtc aggcagcact tttgcccctg ttatgaactg gatgcctttt 2087881 ttcttaagaa gactttccat ttcttttgaa atctctagat cttcagtcgg caatatgcga 2087941 tccgcgtatt caataaccgt taccttaacg ccaaaatcat gaagcataga cgcccattcg 2088001 ataccgataa cccctccgcc gacaatgatg attgactgtg gcagctcctc catttggagc 2088061 gcctcatctg aagtcagtac agacttaccg tccacttcaa gacccggaag cattctcggt 2088121 cttgatcctg ttgcaatgat cacttgtttc gggatcagca tgtcattttc ttcgccattt 2088181 ccccgctcaa cagaaattgt tcccggcagc ggagagaaga ttgacggtcc aaggatacgt 2088241 ccatatccgg tgtacacgtc aatttttcct tttttcatta aatgatttac acccgctgca 2088301 agcttatcaa caacggcttg cttacgctgc tgcacttttt caaagttgag ggacacgcca 2088361 gccgtttcca ctccgaattg atcggcttca cgagctgtcc ggtatacctc tgcgcttcta 2088421 agcagcgctt tactcgggat acagccttta tgcagacatg ttcccccgag tttttccttt 2088481 tccacaacgg ctgtttttaa gccgagctga gcggctctga tggccgcaac ataaccgccg 2088541 gtaccgccgc ccagaatgac tacgtcatac tcagttgcca tggtgactca ctcctgtctg 2088601 tctattcaat acgatattgt ttggattgct cttcgccctg caatactctt agcgcccctt 2088661 gggcaagaga ctgcagttca ttttcacccg gataaactaa aacgtctgaa atccaatcta 2088721 tgtatgatct gatagcagaa acaaagcttt ttccgtacgc aaggcctccc gtcagcacaa 2088781 tcgcttcaac ttcgcctttt aacgccgcgc tggctgcccc gatttccttt gctacctgat 2088841 atgccatggc atcataaatg aagcgggctt tttcatcgcc cccttgaatc atctgttcca 2088901 cttttactgc atcatttgta ccgagatagc ctaaaagtcc gccggtgcca acaagctttt 2088961 tcatgatttc ttcttttgta tattcccctg aaaaacatag atcaacaaga tctcccgcag 2089021 gcactgttcc tgctcgttca ggactgaatg gtccctcgcc gtgcaggccg ttattgacat 2089081 ccaccactcg cccgcggtca tggacgccaa ttgtaatacc tccgcccata tgggtaataa 2089141 tcattttcat gttctcatat cgtttgccaa gggaggctgc cgctttacga gcgacagctt 2089201 tttggtttaa cgcatggaaa atgcttttcc tttcaatttc aggcatgcct gaaactttcg 2089261 caagcactga catttcgtct acgacaacag ggtcgacgat atacgaaggg atattcaggc 2089321 cgtcagcgat ttcccgcgcg ataatgccgc cgagattaga agcatgctga ccggcgtagc 2089381 cgcttttcaa atcctcaatc atctcatcat tcactacgta ggtcccgcct tcaattggcc 2089441 ggagaaggcc gcctcttgcg cagactgcat caaactttga aatattgatt ccctgttcat 2089501 gaagcgtttc gagaatatgg tttttacgaa attcatactg atcaataatt cggtcaaatc 2089561 gctgcagctc ttctatgttg tgtctcaatg ttttttcaaa aatgcttctt tcgttatgaa 2089621 aaacaccgat tttcgttgaa gttgagcctg gattaattgt gagaatgcgt ttttcgtcat 2089681 gtagcacttt cataacctcc agatcaattt cttaacgtct gcttaataca ctgtggccgt 2089741 tttgcaaaaa ctggcttctt gagcggcgca tgcgttcaat ccgttcctct gctaagcggt 2089801 cagccgctaa atatgcagga atgccgtcac gctgagaaat ctcaagtaca cgctcgatat 2089861 tgccgtaaat gccttcaact tttttcaatg cacgttctgc attatagccg taaagctcat 2089921 ctgccacgtt gatgacaccg cccgcgttaa tcacgtaatc cggtgcataa acgatgccca 2089981 tttcgtgaat ttgatcacca tggcgtgtct cttttaattg gttgttagcc gcacctgcga 2090041 tcactttcgc cttcagctgt ttaatggtgt cgtcgttaat agtcgcacca agggcacacg 2090101 gcgcataaat atcgcagtct tgtgaataaa tgtcatcagg atctaccgca cgggcgccaa 2090161 aatcttcaac tgcacgctgt acagattgtt tgttgatatc cgtaacgatt aagtttgctc 2090221 cttcttcatg caggtggcgg caaaggttat aggctacgtt cccaacaccc tgtacagcaa 2090281 tggtttttcc ttcaagagag tcggttccga aagcagcttt agctgctgcc ttcattcctc 2090341 tgtacacccc gtacgctgtg actggggacg gatttccaga agagccgaaa gcaggagaaa 2090401 tccctgtgac atagtctgtc tcatcatgaa tgatatccat atcctcgacc gttgtgccca 2090461 catcttcagc cgtgatgtat ctgccattca gtccttgaat atagcggcca aacgcgcgga 2090521 acatttcctc atttttgtct ttgcgcggat cgccgataat gactgttttt ccgccgccaa 2090581 ggtttaagcc tgccgccgcg ttcttatagg tcatgcctct tgccaatctg agcgcatctt 2090641 caattgccgc ttcttcattt tcatatgtcc acattctcgt tccgccaagc gccggaccaa 2090701 gcgttgtatc atgaatggcg ataatcgctt ttaatccaga ttgttcatcc tggcagaata 2090761 ccaattgttc gtaatcgtat ttctccatat atttaaaaag ttccatgttc gttcctccta 2090821 atgtgtgtat tcttcagatg cgcatattgc cagcgcaatg gaatacagtt tattttcagc 2090881 agagtccgct ctgcttgtta aagcaatcgg tgcttttgct cctgtaatga cagccgccac 2090941 gctggccttg gcaaaataaa tcagtgattt atataaaata ttgccggcct caattgttgg 2091001 gacgagaagg atatctgcgt tgcccgctac gtctcccgaa atttttttct gggccgcggc 2091061 aatttgtgaa actgcgttat ccaaagcaag cggtccatca acaatgcagc ctttgatctg 2091121 gccccttttg tacatttgag ctagagcagc tgcattcacg gtcgcttcca ttttagggtt 2091181 caccgtttcg accgctgcaa gggcagctgc ttttggcata ttgttcccca ctgcatgggc 2091241 cacatgaacg gcattttgca aaatctgccg gagctcttcc agcgaaggag caatattcat 2091301 tgccgaatct gtcacaaaca tcagccggtc aaaatccggt atatcgaaga cagccacgtg 2091361 agaaaggaca cttgctgacc gaagcccctc ctgtctgttc aataccgctt taagcaaaac 2091421 agaagtcggc acattgcctt tcattaaaac gtccgctgtt ttatgatgca cagcacgaac 2091481 cgctaatttc gccgattcct caggagtatt ggcatggacg atttccactt gatgcccttg 2091541 catggatgat gtcagctcgt tcagtttttt gctgtcgccc gttaacaaga aacgggcgga 2091601 taggtgctcg gctgccagct ttacagcccg gatcacttcc tcatcctcag catgagcaac 2091661 cgcaatggtc ttatttttgt gtatcgacgc tttgccgatt aaatctttca gcttcatctg 2091721 ttaccacctt tcttgtttcg actccgcctt ttattatgca agttccatgc cagctcttaa 2091781 gggtgctgtc ataccaggta taccgaaaca ttcgtgcaga tgtttgcgtt tattctgcaa 2091841 attattgcat gccttcattt gcaaggccat atttatccat tttgtaatat aaattccgaa 2091901 tgctgacacc gagagctttt gctgtttttg tccggttaaa atgatgcttt tcaagcgttt 2091961 gctggatcaa atgcgcttca aatttttcta ctgcgacaga cagcttttcg ccttcaatat 2092021 ccggaaaatc aaaacctgtt ccctgatctg tgtcattttc tttttgctca agttcgaata 2092081 caggcaagtg atctttttca atccattcca tatgcggatt cagaaaaatc atggctcgtc 2092141 caaggacatt ttcaagctcc cggacattcc caggccaatg gtaggcagat aaggcgcgca 2092201 aggcttgctg tgagagccct tttacattcc tgccgtaatc ccggttgatc ttttggataa 2092261 gtctgacgct caatgcttca atgtcctcca accgctgccg caaaggcggg atggagatcg 2092321 gatagcgatt gatccggtaa tacaggtctt cccggaatgt tccgtccgcc atcgcctttt 2092381 caatatttac atttgtcgcc gcgatcactc tgacgttgac agggatcgct ttcgtgccgc 2092441 ccactctgac gatttccttt tcttgaagga cgcgtagcaa tttggcctgc atattttgtg 2092501 tcagctcacc gatttcatct aagaaaatac tgccgttatt tgcttcctca aataaaccct 2092561 ttttaccgcc gcgcttcgct cctgaaaacg caccatcctc atagccgaac aattctgatt 2092621 cgagcaggtt ttcagaaagg gctgcacaat tcacgcgaat aaatttattg tatttccggt 2092681 cactttcgtt atggatggca tgggcgaaca gttcttttcc tgttcctgat tccccgcgca 2092741 gcaagatggt tgccggtgtt ttcgcaccga gcttcgcctg ctcaagcgca accagcattt 2092801 gctcgctttt gccgataatg tcgtcaaacg tgtatttcgc ttcaagcgtg cgaataattt 2092861 gtctggcgcg attaagctcc gctgtcagca ttttaatttc ggaaacatcg tgaatcacgc 2092921 cgacgctgcc tttcaaaatc ccgtccacaa tcaccggtgc tacattaacg atcacttctt 2092981 tttcattcgg gccgaccttc attctgacac cgcggacagg acgtcttgtt tcaagcacct 2093041 ttaaatgcat gctttcgcct tcggaaatat cagtgtttgc aggcttgccg atgacttctt 2093101 tttcagaaag ccccgtcatt ttcgtatacg ctttattgat tagcaggccg atgccgtttt 2093161 catcaacgac agaaatcgcc tcatcggagg attgaataat tgcctccagc atcgtacgga 2093221 cctgctttaa gttggtcact tcctctgcca gctcgaccgc atcagtgata tctttaaaca 2093281 cacaaagagc cccgagcaga cgtccgcctt catcaataat cggcagtctt gtggtcacaa 2093341 tttgcaaatg atcgcctaac agctgcttct ggttgtattc aggcactctt gtttttaaaa 2093401 tccgcggcat cttagtgctc ggaatcactt cttttattgg gcgcccaatg acttcctcac 2093461 gtttttttcc gaccattttt tcggccatat ggttaaagag aatgatttct tcattgatat 2093521 caataaaaat cattccatca tgggtggaat taaaaattct gtcatattta taggtttgct 2093581 cttttagcat ttgaatcagg tgctgctttt cttccatcag ctgaaaaacg atgtatgcca 2093641 tttttcccgg catgacaatg gtatcttcat gctttctttg aaggagctcg tcaaacacgg 2093701 cttgatcgcc ggtagtatga atgacgatat ccggtttttg ttgtatgtaa ggtttccaat 2093761 cagatgatac ggcaatccca tactgttctg cttctttcaa tcccggcgcc tcggggtctt 2093821 tgtcaactac ggcaatgata tctatgatgg ctgttttaat cagaatatgt aataacgccg 2093881 ttcccctttt gccggcacct actatcagta ccttttgcat cccgataccc ctttgtatga 2093941 aaaaatttgc acacctattt attccgttgc aataatttgc acaaccctat gttaccacgt 2094001 tttcttctct tgacaaaata ttttttccgc tggacaataa aggaaatgaa aagataaagg 2094061 ggttttctga agatgagccg acttcttgcg cttttaatat tagtcatccc cggggctatt 2094121 tctgctttag gcattaaact gatgagagat acacttttcg gccatacaat caagccattt 2094181 tcagctcttt ggctccaagg gttgtcagga ttcatctttt ttgcgatcgg cctctatgtg 2094241 ctggccgggt tcattttata cagagacaga aaacgcaatc aagtcagccc gcgattcaga 2094301 aaacgatagc tgaaaaaaag ccggagaatg ctccggcttt ttttgttgca ttattcgtca 2094361 ggcaaaacgg tcttggcaat cgttttgtct aacgcttcat agtcataata agaaatcgta 2094421 tcgtacagtt cttttcgtgt ctgcatatca tgaagtcctt ctttttgtga gccgtgctcc 2094481 ttcatcaaac caaacatccg ctcacaagct tttgccgccg ctcgaagcga ggtgacagga 2094541 tatatcacca tgtgaaaccc catatcttcg aattcatcgg cacgataata tggcgttttc 2094601 ccaaattcag tcatattcgc aaggagcgga acggggatac gctcagcaaa ctggcggaat 2094661 tcattctccg cctgtagcgc ttccgggaaa attgcgtccg ctcccgcctc aatgtaagcc 2094721 tctgaacgtt ttattgcggc atcaagccct tcctgcgccc tggcatcagt acgggcaaca 2094781 acaataaggg agggtgccgc ttgtttaatg gcttttattt tttgcgccat ttcctttatc 2094841 ggaactagct gtttgccatt taaatgtccg catttttttg ggagctgctg gtcttccatt 2094901 tgaacggctg ctaccctggc ttcaagcatc tcccgggctg ttcgggcggc atttaagaca 2094961 ccgccaaatc ccgtatcgat atccacaagc aaaggcagat cagctgcacg cacaagatct 2095021 ttggcccgtt cagctatctc tgccgatgtg atgatcccta aatcaggcag ccccctgctg 2095081 gctgtatagg cagcaccgga caaataaata gcagaaaaac cggcttcttt cgcaagcaaa 2095141 gcggccatcc cgtcatgggc gccgggaatt tgaagaatgt ccggtgctga catcagcttg 2095201 cggaaacgcc cggcaagctc ctcttgtgac gattgcttat tgacgatcca cgacatgaaa 2095261 caaaatcccc cttttacatg cagaacatgt ctacgaattc atttacgcgc atcgtttgta 2095321 atgtctcata gctggtacag cgctcataaa tgtgtttgtg ctgtttatca ggaaaatggg 2095381 ttttgagatt gtcagaaaac ttttccagca gtttcggcac tgcttcctct cttcgaaaac 2095441 gatggccgag gggaaactca cattccacca tttccgtgct cgttccatct ttaaaatgaa 2095501 cctgaacggc atttgagatg gagcgtttat caggcttcaa ataatcctcg gtatatgttt 2095561 tattttcagt cacttccatt ttatcacgaa gtttatctat tctcggatca ttcgctgttt 2095621 cagcttcata atgctgtgcg gtgatatcac caaaaagcaa accgattgct gtaatgtatt 2095681 ggaggcagtg atcacggtct gccggattgt ggagcgggcc ttttttatca atgattcgga 2095741 tagctgattc atgcgttctg atgacaactc ggtcaatctc gtcaatccgg ttctttacct 2095801 gcgggtgaag aatgacggcg gactccgccg ctgtctgggc gtgaaattcc gcaggataag 2095861 acactttaaa taacacattt tccatgacat aagcgtcgag cggacgggca agcttgatct 2095921 ctttcttatt gaataaaacg tcttggaacc cccaacccgg tgcactcaag gctgtcggat 2095981 aacccatttc cccttttaac gacatcagcg ccaaatgaac acctctgctc gttgcatctc 2096041 ctgccgccca tgatttacgc gagcctgtat tcggtgaatg gcggtatgtc ctcaatgctg 2096101 cattgtcaat ccatgcattc gaaagcgcat ttttgatttc ttctcttccg ccgcccaaaa 2096161 gctttgctgc aacagcagtt gtcgcaactt tgacaaacag cacatggtca aggccaactc 2096221 gatttaagct gttttctaac gccagcacac cttggatctc gtgtgctttg atcatcatct 2096281 caagtacgtc gcgtaccgtt aacggctctt ttccttcaga cagcctcact cttgatacat 2096341 aatcagcagc ggcaaggatt cctcccaagt tatcggatgg atgcccccac tccgccgcca 2096401 gccacgtatc gttgtaatcg agccagcgaa tcatgcagcc aatattaaac gctgccctca 2096461 caggatcgag aacatatgac gttcccggca ctttgcttcc attcggcaca gtcgttcctg 2096521 gaacaatcgg gccaagcagc tttgtgcatt ccggataccg tagcgccaag attccgcagc 2096581 ccagggtatc cagcaataca tgccccgctg ttgtatacgc ttcggcacta gtaatctctt 2096641 tctcaagcac atagtctgtg atttcttcga taacacgatc cgttttcggc attctaccag 2096701 ctcctttcat gattttgttt gatatcgcgg gcccatgtaa ctgacacggg gacggaagag 2096761 ccgattattg gcatgctgtt cgatcacatg ggcgcataaa ccggacgttc tcgcgctgaa 2096821 aaagatcggc gtatataaag gaatcggtat gccgagcatc caatacactg gggcagcata 2096881 gtaatccaaa ttcgggtaaa gccctttttc cttctccatc agccgctcac ccgcttcgca 2096941 catctcatat aaacgatggt caccggcttt atcgcataat tgctgcagcg cctctttcat 2097001 catgagtgct ctcgggtcca tttttttcat atacacccgg tggccgaagc ccatgatttt 2097061 ttcttttctt ttcagttttg tttgcaaaag ctgctcaaaa tcagatgtcg tttttgcctc 2097121 caaaagcaaa tacatcacag cttcgtttgc tcctccgtga agattccctt tcagggaagc 2097181 gacagcccca gtcaaagccc cataaagatc tgaatgtgta gatgcaatga ccctggccgc 2097241 aaaggttgaa ttcggcatct catgctcact gtacaggacg agcgaccggt caaaaatctg 2097301 ttcttccaat gaagacggca atttccctgt catcatgtag agaaaattcg cactgtagga 2097361 tagggtttga agcggaagaa tcggttcttt cttattaatg atcctgtagc tggcagcagt 2097421 gagggcaggc attttcccaa gaagctgata ggcgcgttct ttgtttgcgg aaggagaccg 2097481 atcatcaatt tgccgatcat agccagcaag tgccgacagg ccggtacgca gaccatccat 2097541 tggatgagtg tcctcaggga gcagctcaag cagacggaga tgatcagcag gcaggcttga 2097601 ggcactgttt attttacgtt ccagcgtttc catttcactt tcttctggca gcctgccctc 2097661 cagcaataaa tggacaagct ccagatagct ttttgtttca gaaagttcta ttaaatcata 2097721 gcctcttatc aaaatctggc tggactgcgt gtcaagataa gaaatatgag tttctgccgc 2097781 aatcacaccg tccaaccctg gagaataatg ctgtttctcc tccatatcct caacctccgt 2097841 ttttgcgttt tttgtctatc aggttccgcc aagcaaatac ttggaaataa tcagtctttg 2097901 aatctcgttc gtcccttcat aaatttgcgt cacctttgca tcgcgaagca ggcgctcaac 2097961 tggataatcc ttcatatagc catatccccc ataaatttga acggcgtcta acgccgcctt 2098021 tacggctgca tcggaagcaa attgtttagc catagacgct tcttttccac agtttaggcc 2098081 gcggttatga aggtctgcag cgtggtagac aagatgtctt gccgcctcag ctctagtcgc 2098141 catatcagcc agcttaaatg atatgccttg attggctgca atcggccttc caaattgcac 2098201 tcgctgcttc gcataatcaa cggcatgctc aagagccgcc tctgcaattc cgagggcctg 2098261 tgccgcaatg ccgatccggc cgacatttaa attcgccatg gcaatgtgaa agccatcccc 2098321 ctctttgcca agcaaattgg cttcaggcac ttctgcatta tcaaaaatca gttccgtagt 2098381 attggagcca taaagcccca gctttctttc tttttttcca acggtaaaac cgggtgtgtt 2098441 tttttcaaca ataaaagccg aaatcccgtg cctgccttga tctggagctg ttaaagcaaa 2098501 tgtgatatag atatcagctg ctccgccatt cgttatgaat attttcgatc cgtttaatag 2098561 gtatttgccg ttctttttga ttgctgttgt gcggaggctc ccggcatccg accccgagtg 2098621 aggctccgtt agtgcaaatg cgcccaaatg gtctcctgac gcgagatttg gtatatattt 2098681 catcttctgt tcttcgttgc cgaaatacag aatcggattc gtgccgactg aggtatgaac 2098741 ggagagaatc acgccgacag ccgcgctgat tctagaaatc tcatgaattg ccaaaatata 2098801 agaaacaacg tccgctccag caccgccgta ttgttccggc accggtattc ccatcagtcc 2098861 gtgtttaccc atttttttga tcagctgaaa gggaaattcg tccgttttct ccatgatttc 2098921 cgcagcggga gcaatttctt ttcgtgcaaa atcacgcacc atttttcgca tcatgacttg 2098981 ctcttgggtt acatgcaact cggccacccc cggatggaat agacttcagg aagtcttctc 2099041 ctcatagtca taaaaaccgc gtccgctctt tttgccaagc cagcctgctt tgacatactt 2099101 gcggagcagc gggcaaggac ggtatttgga atcgccaagg cctgagtgaa ggacttccat 2099161 aattgataaa cacgtatcca gtccgataaa atccgctaat gcaagcggac ccatcggatg 2099221 attcatgccc agcttcatca cttcatctat tgcctccggc ttcgccactc cctcatacac 2099281 gcaatagatg gcttcattaa tcattggaag aagcacacgg ttggaaacaa acccaggaaa 2099341 atcattgact tctaccgctg ttttccccat cttttccgct aatgccataa catctaaggc 2099401 cgtttcttct gatgtagcca agcctcgaat cacttctacc agcttcatta cagggacggg 2099461 attcataaaa tgcatgccaa taacccgttg aggccggttt gttacagcag cgatttctgt 2099521 aataggcaag gaagatgtat tgctggccaa aatcgtatga ggcgggcaaa tgcgatcaag 2099581 tgttttaaac atctcagttt ttgccgccat gttttctgcg atagcctcaa tcacaatgtc 2099641 cgcatgctct gcctcctcaa gtgtttgaga aatcgaaatg cggttgatta cgctcttcac 2099701 ttccgtctcg gtcctttttc ctttctcagc atcacgggcc agctgtttct tcagccgttt 2099761 caatcctgcc tccgcggcct ctggattcac atcatacatc cgcacataaa agcccgcgtc 2099821 ggcggctgtt tgagcaattc cgctccccat ctgacctgcg ccagctacca tgatttgttt 2099881 gatttccatt caaatcccct ttttcatcat gttttaatga acctgcacta agacggcgtc 2099941 tccctgtgct gccccgctgc aaatagcggc aacgcccaga ccccctcccc gtcgctttaa 2100001 ttcataaaca agcgtcatga gaattctcgc accgctcgcg ccgatcgggt ggccgagcgc 2100061 gatcgcaccg ccattcacat ttactttttc aagatcgaaa cctacgattt tttcacatgt 2100121 caaaacaact gaagcaaaag cttcatttac ttcaaacaag tcaatatctt ggacagttaa 2100181 accattcttt ttcaggagct tgttaatagc aaaccctggc gctgccgcca gctcgtgcgc 2100241 tggcattccc gtagttgaaa aaccaagaat tgtagccaga ggccgtttgc caagctcagc 2100301 agctttttcc tcagacatca gcacgaacgc gccggctccg tcattgactc caggagcatt 2100361 gccggctgtg atagaaccgt cacttgcata aatcggagca agttttgcga gctgatccag 2100421 acttgtgtca cggcgaatcg cttcatcttt atcaacaacg tttggttttc cttttcgacc 2100481 gatccagttg acgggaacaa tttcatcctg aaacttccct tcatcggcgg ccttagctgc 2100541 ccttgcatga cttctcaacg cccattcgtc ctgctctctt cgtgagattg catattcctt 2100601 ggcagctgta tttccgtgaa cagccatgtg cacctcgtca aatgcgcacg ttaatccgtc 2100661 atacaccatt aagtccctaa gctcgccgtc ccccatccgt gctccccagc gcccggcggg 2100721 aacggcatac ggaatattgc tcatgctttc catccccccc gcaacaagta tgtccgcatc 2100781 ctgcgcccga atcatttgat cacataaagt gacagcgcga aggccggaag cacagacttt 2100841 attcagtgtt tctgacggca cactccaagg cattcccgcc agacgggcag cttgacggga 2100901 aggtatctgc cctgagccgg cctggacaac catgcccatg acgtttcctt ctacatcatc 2100961 tccagagact ccagcctgtt gcagcgcctc cttcatcaca atgcccccaa gctcagcagc 2101021 tttcacctct ttcaaaactc cgccgaattt gccaaatgga gttcttgcag cacttacaat 2101081 gactgttttc ctcatggttt cacctcattc agaagataga cagcgcttac aatttctagt 2101141 tgtcttctat gaatgtatgc tttgaaacgg gcatgaatga atgaaaaaag aaggctgcgt 2101201 caaacagcct ccttctaaca actattcatt tttcagcaat gccgaagcct tttctggaaa 2101261 gtcggtaaac atgccgtctg ctcccgcttc aatgagacgc ttcatatctt ccggacgatt 2101321 gactgtatac ggccttacct taatcaaacc gttcctcatt ttcttcagta cttcatctgt 2101381 gacccctggg ctgtttatct tcgggtgata gccggaagcc ggaatagacg cgatatatcg 2101441 atctgcctga taaagcacat ctgaagttaa tactgcccgt tcgatatgcg gtgcaagccg 2101501 ggcgcacagc gccaagctgt catgattaaa cgtggatagg atgactctgt cctctacatt 2101561 aaatcgcttc actgcctcca gcactttttc ttccattccc tcatagcgga tcacgctgtt 2101621 ttttaattca atgttgatga gaaaatcctt ttttaccgcc cacgagagca catcttctag 2101681 cagcggcact tttatatcgc tgtacgcttg atcgtgacca gcggccgcat tcgcagtctt 2101741 tacctcatca taggctgtat ccttcacgaa tcctttaagt gatgtcgtgc gattaagtct 2101801 ttcatcatga attacaacaa tgcgtccgtc tttcgtcagc tgtacatcaa gctctatccc 2101861 atccgctccg gcttcaattc ctttttcaaa tgcaagcatt gtattttcgg gaaattgacc 2101921 tgatgccccc cggtgggcaa aaatctttgt catcgtttca cctcaaaccc taaagttttc 2101981 tccattatac ttattttgtc ggctccactc taggattaag gctgtatcaa tctactgatc 2102041 ataataagaa tcaatgccat tgacaatcgc atctgcggcc ttttgctggt attcttcact 2102101 tcccagcttg tccgcgtcag agctgttcgt gataaaccca agctccgcca acacacttgg 2102161 catttgtgaa tatgtaatga cgtaaaagtc tgattctttc acgcccctgt ctctcgtttg 2102221 taaggaagaa acgagctgtg actgaatatc ggatgccaga cgccggctgt tctccccttc 2102281 ataatcagat tgaaaatacg tttctgttcc tgaagctgaa gcaacccctg aattcacatg 2102341 aatgctgaca aaaaggtcag cctgattggc acttgcctta gccactcttt cctccaaggt 2102401 cagaaaatga tcgtcagacc gggatgcaac aggattggct ccctcctctt ttagtttgtc 2102461 tgtcacatgc tctgagacag ccaaattaat atccttttca aagagcccgt ttccgaccgc 2102521 tccactgtct tcaccgccgt gtccggcatc aatatacact gttttccctt ctatcggctc 2102581 tgctgcctgt gcacaaggcg cgagcgtcaa agccaatccg cacagcgcca agctcctcca 2102641 taacattctc aacttactcc ctccggtcac gagttctttc gcagctgaat atcttccagc 2102701 tgtaaagttc cattatcctt ctttgtatat ttcaccagga catgtgtctg atctggcagt 2102761 gattcacatt catcacgttt atccttcgga acttgtatca tggtttcttc tccattaaga 2102821 gaaaccgcaa tcgtatgagg atcagccgag ccaatgtatt ttccctcttc ggtaaacctc 2102881 ggcactgagt catccgcact tgcaacactg caccccgaaa gaaagagcgc agtaaacagc 2102941 aaaagaaccg tttgtttcac atgaccacct cttcctgatg tttggctttt atctttgacc 2103001 agaatggaga atttgtaaag acaacgcgaa tgcaggcgag caagttccat gattttcaaa 2103061 agggctatac gacccgatca tttcctgttg ttagaaagat aacgagcaga tttgtctatg 2103121 aggatggctc taattgaggc gccaattaga aaaaattagc ggaaagaagc aactttttat 2103181 tcattttaaa aaatttgaga atagggtgag caaatcgttt gacgggtggg tcagccaagc 2103241 gtaacctttt aaaggatatt tactttattg aaagaagtta aagccatgaa aaaattcgtt 2103301 ctgctgctgg cggcagctgt catcacatgc tccatcggcc accaaatcag tggcggctac 2103361 aaaggccccg aaaaagagcg gccaaaacat cactctgcac tcaagatatt cagtcggtaa 2103421 agcagatcaa ttgcattaat ttttacatat aggctagaat atgtgcgaat ccaaacgaaa 2103481 gaagatgatc aaatgaatcc taagtataag ccactttttg aaccatttac gtttaaaagc 2103541 ggcgttacaa tcaacaaccg gatcgcagta gcaccgatga ctcattacgc ttctaatgaa 2103601 gacggtacaa tatctgaagc ggagctcgac tacatcatcc cccgttcaaa agagatggga 2103661 atggtgatta cagcctgcgc aaatgttaca ccggacggaa aagcattccc cgggcagccg 2103721 gccatccatg acgattccaa cattccaggt ttaaaaaagt tagcacaagc cattcaggca 2103781 caaggcgcta aagctgttgt acaaattcat cacggcggta ttgagtgccc gtctgagctc 2103841 gttcctcaac aggatgttgt ggggccaagt gacgtgtttg ataacggcaa acaaattgct 2103901 cgcgcattaa cagaagaaga agtggaaaac attgtgaagg cgtttggaga agcgacaaga 2103961 cgcgccattg aagccggctt tgacggtgtc gaaattcacg gtgcaaacgg ctacttaatt 2104021 cagcagtttt attctccgaa aaccaaccag cgcacggatc gctggggagg aagcgatgaa 2104081 aaacgattag ccttcccgct cgctattgtc gatgaagtga aaaaagccgc ttcagaacat 2104141 gcgaagggtg cattcttagt cggctaccgc ctgtctccgg aagaacctga gacaccggga 2104201 ttgacaatga ctgaaactta tacgcttgtt gatgctttag gggataaaga attggattat 2104261 cttcatatct cactgatgga cgtgaactca aaagcgcgcc gcggtgcaga tccgactcgc 2104321 acacgcatgg acttattgaa tgaacgtgtc ggaaacaaag tgccgctgat cgccgtcggt 2104381 tccatccatt ccgctgatga cgcgcttgcc gtcatcgaaa acggtattcc actggtcgct 2104441 atgggacgcg aaattctagt tgaccctaac tggacggtaa aagtaaaaga aggccgtgaa 2104501 aagcaaatcg aaacagtgat caaaggcaca gataaagaaa aatatcattt gcctgaaccg 2104561 ctatggcaag caattgtgaa cacacaaggc tgggtgcctt ataaagatta atgtgcaaag 2104621 actgccgaaa cgattcggca gtcttttttc cctttatata aatagtttgt gtacacatct 2104681 aaacagcaaa agaaagagct ccccaccaac ttcgaaaaga aaatccagga aaaacccctc 2104741 acgctttctt gcttttttct ttttcattcg tacgtctcct ttttacatga atacgcctta 2104801 cttacgattt tgcaggagaa aggtttcatt ttataacgga cacatctagg gtcgatcatg 2104861 cttcgtgatc ctataagatg tatgaatgga ccaagagtgc aggtaatacc gccatttgct 2104921 ttccttactt ttcaaaccta tcctttacta tatgcggata cttaatattc ttctcccata 2104981 ctacaaatgt ccccaaaaca aaacgcctcc tatttatcag cgcaaactaa taaataaaag 2105041 acgtttgatt taatgaccac ttaataagct catgtttaag aagccttatg ctctaacctc 2105101 agcttatccg caaccattgc aatgaattca ctgttggtag gtttagcttt tgtcatgctg 2105161 acagtataac caaacaacga ggaaatggaa tcaatgtttc ctctgctcca tgccacttca 2105221 attgcatggc ggatcgctct ttctacacgg cttgcggttg tgttaaattt tttggcgatg 2105281 tccggataga ggacttttgt aatgctgccg agcaattcga tgtcattgta taccattgag 2105341 attgcttcgc gcagatagag atagccttta atatgggctg ggacgccgat ttcatggata 2105401 atgcttgtga tgctcgcgtc gagatttttc ttctttggtt caggctggct gctgcgtata 2105461 atactgcttt gcgatgatgg cgcacgatgc gtcacactgc tggcatttcc gctgacctgg 2105521 cggatatggc cgacaaggtt ttccatatca aacggtttga gaataaagta ggacgcgcct 2105581 aaatcgacgg cctttttcgt gacatcttcc tgcccaaagg ctgtcagcat aatgacattc 2105641 ggctgttttt tcagatctga ttccctcagc ctctctaaaa ccgcaagtcc gtctagatgc 2105701 ggcataataa tatctaatac gagcacatcg ggatcttttt ctttaaacag cgacaggcat 2105761 tcctgtccgt tataagcaac gccgatcact tccatgtctt cctgtccttc tatatattca 2105821 cttaacaggc ttaccagctc tcgattatca tcagcaacac aaactttaat tttctccacg 2105881 tttcttcctc cccaaatgta gttaacagga ttcacccttg ctacatgttt acattcgaca 2105941 aaaccgctat ataccctcta aaaaaatcat aatcaccaat attagtggca tatctttgtt 2106001 attctatgtt tttctctgtt tttcgactaa aaatgaaatt tgacaaacaa ggaaacgtga 2106061 atttgtcgaa aaatcttctt ttgtatattt taccgtatgt attctgagaa gtgaagaggg 2106121 atcaaaataa aaaaactgcc ggaaactccg gcagtcagct tgctttttct tttccataaa 2106181 tatcgattcc tgcttctgac agcatccatt caatatgaac accgtagccg cttgtcgggt 2106241 catttacaaa tacatgggtg acagcaccga tcacttttcc attttgaatg atcgggcttc 2106301 cgctcatccc ctgtacgatg cctcctgttt ctttcaacag tcttggatcg gtaattttca 2106361 acaccattcc ttttgtcgca gggaattttt gcggcgttgt gctgacgatt tcaatatcga 2106421 atttttctac tttgtcatca tcaataaccg ttaaaatttc agccggccct tttttgactt 2106481 cggtagaaaa cgcaaccggc aatgcttgat ctgatatgtt gttttgaatc ggctgatgca 2106541 gtgtgccgaa aatcccaaac gggctgtttc tgttaatatc cccgatcgtt ttgcgttctg 2106601 aggaaaatcg cgccagtttt tctcccggat taccgcctgt ccctttttca attgatgtta 2106661 cagtggattt aacgatttct ccattctcca ctacaattgg tttctttgtg tccatatcgg 2106721 aaatcacgtg gccaagtgct ccgtattttt ttgttttcgg ttcataaaag gtcatagtgc 2106781 cgatgccagc agcagaatct ctgatatata acccgattct gtatttgcct tctccttcat 2106841 ccttttctgg gatcagcttc gttttgattt tctgtttatc acgtttgatc agtaagtcta 2106901 aagattcacc agttttccca gccttttgaa taaatggggc tacatcattc attttttcaa 2106961 ttttctgtcc attcatctca ataatgatgt cgcccgcttc aattcctgcc gtttctcccg 2107021 gagatttttt gccttcactt gtattgattt gatgaaatcc gacgacaaga acaccgacgg 2107081 aatgaagttt tacaccgatt gattgtccgc caggtataac ttttaaatca ggaagaacat 2107141 gcacttttgt ttttttaatt ggaaatccgg caagatcata taccaattct gactcacctg 2107201 attttttgcc cgtcaccttg atttcatgcg gatctttctt tactgtaaac gcttctgagg 2107261 attctgatgt ctgagcgttt accgataaac tcgtttcaat cgcttgtgtt tgggtttcaa 2107321 atactctcat ttgcgttgga atcagtaaat attcttttag cggtttgcat aaacctacac 2107381 ttaataacga aacaaggaga attaaaccta ctgcttttct gatgttatcg ggcattcact 2107441 acttcactct cctcgctcct atcccacacc ttctttatga cttgctgcta catcatttaa 2107501 ttttgccttc tgacggctta tttataactg tcatatgaag aaaaacattg gatatactga 2107561 tgaacgaatg gatgtgcacg aaaaaaataa gctgcgcttc tcgcgcagct tacccagttg 2107621 ttttgacttg atccgcttgt tttaaaagtt ctttcgcatg gcgtttcgtt aagtcggtta 2107681 cttcgacacc tgcaatcatg cgcccgattt ccgctacctt ttcctgctta gagagcggct 2107741 tgacacgtgt cgtcgttctg ccgtctttta actccttcgc aatataaaga tgcgtatcgg 2107801 ccatggcagc cacctgaggc aggtgtgtaa tgcacagcac ttgtgatcct attgacacct 2107861 tatggatctt ctcagcaatt gcctgtgcga ccctgccgct tacaccggta tcaacctcgt 2107921 caaaaatgat cgatgtcaca tcctgttgtg aggaaaaaat gctttttatg gcaagcatca 2107981 cccgtgacag ctctccacct gaagcgactt tcgaaaggga tttcagcggc tcgcctgtat 2108041 tggttgaaat taaaaacttc accaggtcaa tcccttgttc agtcagctga acgggctggc 2108101 cgtttacaag cggcgcctct tcattgcgtg acgctgttct gaccttaaat tccgtatcaa 2108161 aagttgattt ttccatgtac aggcttttta attcccgatg aatctcatca gccagctttt 2108221 tcgcccatgt ttttcggatt tgtgacacat ttgccgcttc cactgcgaca tctttgccga 2108281 cggagtcaag ctcctttttc aagctttgaa ggtggctgtc cctgttttca atttggtcaa 2108341 tctcttcttc aattttagaa gcatattcca aaatgtcttc aacagtggca ccgtattttc 2108401 gtttcagctg tttgatttca ttaagtcgcg tctcaatata gttcaggcgt tccggatcaa 2108461 attcaagctc atccagcata tttctcatct gaaatgtggc atcctcaagc aaatagtagg 2108521 agttcgaaac actttcagac atttttttca gcggttcgtt tatatcagat atatcttcaa 2108581 gctgcgctga tgccattcca acccagtcca atccgccctg ctcactgcga agcgcgttat 2108641 atgcattttg cagcgactca tatatcttct caaagtttga aatttgctgg cgctcttctt 2108701 ggagctgttc atcttcgtta agctcaagct ttgccgattc gatttcttcg agctgaaatt 2108761 gaataagatc aagacgatgg gccatttcct gttcgctttc agaaagctgc ttaagctttt 2108821 tgagcagctt cacataccgc tggtaccctt cctgatacgt tttgagcgcg ctttccactt 2108881 cggccccggc aaacttgtcc aaaagctgga gatgattttc gtcttccatt aacagctggt 2108941 tatcgtgctg cccgtgaata tctaataaaa gcctgccgat ctctcttagt gaagcaatcg 2109001 tgacaagctt gccattgaca cggcaaacgc ttttcccgct cgtgctgata tcccttctca 2109061 tgacgatcat ttcgtctgaa acgtcgattc cctgctcagc gcatacgcct aaaacaggat 2109121 ggccgctctc caacagaaac agcccttcaa gttcggcttt tgcttcccca tatctaacaa 2109181 attcagatga tccgcggcct ccgactaaaa gagaaatggc atctatgatg atggatttgc 2109241 cggctccggt ttctcctgtt aaaaccgtaa gcccgcgttc aaaagaaacc gtcagttcct 2109301 caataatggc aaagttttta atcgatagtt cagctaacaa acagcattac acctcttatc 2109361 tttgttagat tttctgttac agcagttcaa ggagcctgtt ttttacgcct tctgtatctt 2109421 caggagtccg gcaaataatt aaaatcgtat catctccgca aatggtcccc atcatttcat 2109481 cccagtccaa attgtccatc agcgccccga ttgcctgggc attgcccggc atcgttttca 2109541 gcacaatcat atggcttgct gagtctattt tcacaaatgc gtccatcaat gcccgcttta 2109601 gctttgacag cggattgaaa cgctggtccg ccggaagact gtatttgtaa gaaccattat 2109661 ttgtaggcac ttttacaagg tgaagttctt taatatcccg tgataccgtg gcctgcgtta 2109721 ctttgtatcc atcctgcttt agcatgtcga ccaattcatc ctgcgtttcg atttcattgc 2109781 ttgtaatgat ctctctgatt ttaatatgcc tctggccttt gttcatgtaa gcacctctat 2109841 ttccaagctt atctgttctt ttatgttata tgattctctg cacattgtac atgaatgcag 2109901 aaaaaaggaa taatagcgcc ctattattcc ggtacatctg cttttttttc ttttaacgtc 2109961 ttatgtgctt cttctacaac gcgcatgatc tcttcttccg gcagttcctg gccttcctgt 2110021 ccctctcccg gccaatgcaa atgaaggaga aactcaatat ttccgtctcc tcccgtgatt 2110081 ggagaaaatg acaagccttt acagatatag ccttcagcgg cagaaaaact gatcattcgc 2110141 ttgagcacat cagcatgcac tttaggatct ctaacaatcc cttttttgcc gacggattcc 2110201 cgtcccgctt caaactgagg cttaactaaa gccatgcagt cgctgcccgg tacgagcaaa 2110261 gtccttagga caggcaggat gagccgcagt gaaataaagg acacatcaat tgtggcaaac 2110321 tccggcatgc cctttgtaaa gtctgccggt gttgcataac gaaagttcgt ccgttccatc 2110381 acgacgaccc gttcatcctg tctaagcttc catgcaagct gattatagcc tacatccaca 2110441 gcgtatgact gtttagctcc attttgcaaa gcgcagtccg taaaaccgcc ggtggaggag 2110501 ccaatatcaa tcataatttt atctttgaca gagacgggaa attccttcaa cgctttttcg 2110561 agctttaagc cgcccctgct cacatacctc agcgggtttc ctttgacagt taacggaagg 2110621 tcgcggtcaa ttttttctcc aggcttgtcc aagcggtttt cgtttgaata gacgatcccc 2110681 gccataatgg ctcttttggc tttttcacgc gtttccgcca gccctctttc cactaataat 2110741 acatctaatc gttctttctt tgacgtcatg atccaattcc tttgtgtgtc tttggtggca 2110801 tcagtaatct aatacgattt gccacctgct gttttgtcag tccaatttcc tcaagaagcg 2110861 ctgttacact tccgtgttca ataaaccgat caggtatacc cattctgtca atcggagtat 2110921 gatattcacc ttgatcatga gcgaattcta aaatcgagct tccgaaaccg ccttctaaga 2110981 ccgcttcttc aattgttaaa attggcaagc cttcttttag gatactcttc atcatctttt 2111041 catcaatcgg cttaataaaa cgcgcattca caacgcgcac ggaaaggcct tctttctgca 2111101 gctcttcggc tgcttcaatc gccatttcga ttgttgtgcc gaatgttaag atgacagcat 2111161 cgttccctgg acgcagcacc tcccacgtac cgatcggaat cgttttcaac tgttcatcca 2111221 tttttacgcc gagtccgttt ccgcgcggaa aacgcattgc tatcgggcct tcgtcatagc 2111281 taagtgctgt atgaaccatg tgctggcctt cattttcgtc tttcggcatc attaagacca 2111341 tgtttggaat gtggcgcata aacgcaatat caaacacgcc ttgatgtgtc tctccatcag 2111401 cgccaacgag tccagcacgg tcaattccaa taaacacatt agcgttttgg cggcagatgt 2111461 catgaacaac ttggtcatat gccctttgca ggaaggttga gtaaatcgcc aaaaacggct 2111521 tcataccctg cattgccata gctgcagcca ttgttgcggc atgctgttct gcgattccta 2111581 cgtcgaacat ccggtcaggg aattcctttg cgaagccttc aagctttgaa ccgacaggca 2111641 tagccggcgt aatggctaca atgcgtccgt cctcgcgcgc cattcgctgc acagttccgc 2111701 tgacaagacc gctccacgaa ggagctgcgg ctttcggctt tacaaagtca ccggtattaa 2111761 ttttatatgg tccggtacca tgccatgtcc caatcgtatc ggtctcagcc ggtttgtacc 2111821 ccttcccttt tttcgtaatg acgtgcagaa gaacagggcc tttcgttttt ttggcgtatt 2111881 gaagattctc aatcagctca tgataagaat gtccgtccac tgggcccaaa tacgtaaaac 2111941 cgagctcctc gaaaaacatt ccggagacga gcatgtattt caggctgtct ttgacccgtt 2112001 ccgccgtggc ggcaagcttg cccccaactg ccggaatctt tttaaataag tattcaagct 2112061 catctttgac ccactggtat ttccccgcag tgcggagccg tccgagcata gagtgaatgg 2112121 caccgacgtt tggcgcaata ctcatttcat tatcattaag gatgacaatc atgtcttttt 2112181 tctcgtcgcc gatgtggtta agggcttcga gcgccatacc gccggtcagc gcgccgtcac 2112241 caatgatcgg aataatatat tcatccgttc ctttaatatc acgggcagct gccattccca 2112301 tcgcgcctga cagagaagtc gagctgtgcc cggtttccca aacatcgtgc tcgctttcac 2112361 tccgctttgg aaatccgcaa agccctttgt actggcgaag cgtcgcaaat tcttttccgc 2112421 gtcctgtcag cagcttatgg acatacgact gatggcctac atcccataaa aatttgtctt 2112481 tcgggctgtt aaattcctta tgcagggcaa cagtaagctc tacgacacct aagtttgggc 2112541 cgatgtggcc gccggaagcg gataaacttg taattaaaaa ctgacggatt tcatcactta 2112601 atttctctaa ttcatcaatg gacatgtttt ttaaaaacga cgggtcctgt attgataaaa 2112661 gatccaaagc ggatcaactc actttcagca tgaatttctg caatgataca tgtcttttgc 2112721 atgccgagct gacaataatc tcagacataa aaaaagacaa acgcgctttt ccttttcatt 2112781 tttcatataa actgcttaca ttttaccata cctcgtgcag ccgcttcaaa ttaggatcgt 2112841 tttagtgatc tcttgccgca attaaatcac aaagctcata taaaaggtct ttttgaagag 2112901 agagtccgcc gatcaatcgc ttcgcctctt ttatatgaac atccaattta tgtttggccc 2112961 cttccaatga aagaagcgac gggtatgtcg atttgtcatt tgtggtatcc gagccgacac 2113021 gtttgccgat tttctcttca ctgccttcta aatctaaaat atcgtctctg atttgaaatc 2113081 cgattccaat gtggctgctg aaggtacgca gtgtttcaat gtcttcctca ggcgcatcag 2113141 ccaaaatagc accggcgatt acacaaaagc caaggagctt ggcagttttc cgttcatgaa 2113201 tggattcgag ctcttcaagc gtgacttgtc ggttttccgc ttccatatca gctacttgcc 2113261 caccgaccat gccttcggtg cctgccgctg aaatcagttc attcacaagc cgcaggcgct 2113321 tttctgctga cacctcgtct gacacgtggg aggtaatcag cttaaagctt tctgtgagca 2113381 gcccgtcacc cgctaatact gccgtcgctt caccaaacac tttatggttt gtcggcttcc 2113441 cgcggcgcaa atcgtcatca tccatgcatg gaagatcatc atgaattaac gaatacgtgt 2113501 gaatcatttc gacagcacag cccaccggaa tgccgtcttt ttcgcttttt ccatatgcat 2113561 ttaaaacagc cagtacaatc agaggccgca accgctttcc gccggcctgt agagaatata 2113621 gcatagattt ctttaatgag tccggcatat caagcttttc tgtatagaca gaaagctgat 2113681 tttcaattgt ttttttccgg tccgccagaa agctcgttaa tttatttgtc accttcgtct 2113741 tcctcctgaa cactgaaagg tgccagttcg ccgtcttctt ttaaaatgaa gtccatttgc 2113801 ttttcgactt tttgcagctt ttcatggcac atttttgaca gagccatgcc ttcttggaaa 2113861 tagttaatgg cttgctctag aggcacatct ccctcttcaa gctttgatac aatgctctca 2113921 agccctttca tcgcttcttc aaatgtcatg ttttcatttt ttttcacgtc tgtcattttt 2113981 cttcccctct cttttctaat acttcacagg tcagcacgcc atccttcagc ttgatttcaa 2114041 gccggtcctg ctcttctatt tgactgacac ttttaatgag tttatcttct ttataagcca 2114101 agctgtatcc tctttccatc acttgaagag gacttagtgc attcagcttg ccaagaacgg 2114161 tttgaaattg ggaatgcagc tgcttcattt ggatattcat attttttctc agctgatttg 2114221 tttgttcctg gtatcgtgtt ctcgcttgtt tcagctgttc atgaggatgc aatgcctcta 2114281 atctgtacgt ttcacgctcc agctgtctgc ttttccgatc taaaagagcg gtcagctgtg 2114341 cttgaaactg ctggtacgcg aggtcaaact gctgctcttt ttgcgcatac aaacgctttg 2114401 gaaaacgaaa ggcataggac gattgcagcg tttgtatccg ttcttttttc tggccgagat 2114461 gctgctgcat tgctcttgtc attctgactt ccgctgtttt tgtccgttcg attaaatcag 2114521 tggtatgagg cacagcaatc tcagctgctc ctgtcggcgt cgcagctctg atatcggcga 2114581 caaaatcact aatcgtaaaa tccgtctcat gtccgactgc cgatataatc ggaatattgg 2114641 aagcaaagat ggcgcgtgct acaatttctt cattgaatgc ccacagttct tctatcgaac 2114701 cgccgcctct cccgacaatt aatacgtcgc aaatctcttt ttcatttgcc tcttcaatgc 2114761 gcgtaacgat ggatctgctc gcattttcac cttgtacgag cgctggaaga acaatgactt 2114821 ttacaagggg atatcttctt tttagagttg taataacgtc tctgacagcg gcacccgttg 2114881 gagatgtcac aaccccgatt gtggctggaa atgcggggat ttgttttttg tagcggtcgt 2114941 caaataaacc ttctccggca agcttctttt ttaattcttc gtacgctaaa taaagcgctc 2115001 caaccccgtc aggctgcatt tctttggcat ataattgata gtttccgctc ggttcatata 2115061 cggaaattcc gcctctgacc agcactttca ttccgttttc aggtttaaaa ggcagacgct 2115121 cgctttgtct cgcgaacatc accgactgca ttcttgcgtt ttcgtctttt aaagtgaaat 2115181 aaatatgccc tcgtgtgtgt atctttacat tcgacaattc gcctttaatc caaatatttt 2115241 caaggtgagg atctacatcg aattttcgtt ttatatactt tgtcagcgct gagacggtca 2115301 catacgctgc ttcacccatg tctaaaaact cctctcctaa gcattcctgc accataacta 2115361 aagaaaaccc gccctggctt taggagcctg aagaagcggg tatcgtgctc atattcaagg 2115421 cgggtaaaca tttcgcctgt gaatatctcc aattatctat gataacgtac gtttcgcaga 2115481 tttaacagta ttatgcgcaa gcatcgtgat ggtcatcgga cctactccgc ccggaaccgg 2115541 cgttatgaag gacgcttttt cctttgcccc ttcaaattca acgtctccgc aaagctttcc 2115601 gttttccaga cggttaacgc cgacgtcaat gacaacagcg ccctctttga tctggtctgc 2115661 actgatgaag ttggctctgc cgactgccac caccaggatg tccgcttttt tcgtatgttc 2115721 agtaatattt tctgttcttg aatgacagta agtaaccgtc gcgttttcat ttaataaaag 2115781 ctggccgaca ggtttgccga caatgttgct tcggccgact acaacaacct ctttaccgga 2115841 aaggtcaata ttggttttct tcaaaagctc aacaattcca tgaggcgtgc aaggaagaaa 2115901 cgtatcttcg ccaagcagca ttttccctac gtttaacgga tgaaaaccgt ctacatcttt 2115961 atcaggggag atacgttcga tcaccgcttt ttcagaaata tggtctggga gcggaagctg 2116021 aacgagaatg ccatgaaact cagggtcttg gttatattga tcaataatgg aaagcagttc 2116081 agcttctgtg aggctgctgt caaattgatc gagcttgaaa ttcattccca ttgtttctgc 2116141 cgcttttttc tttcctcgca cgtaagagtg agaagcagga tcatctccaa tcaaaataac 2116201 cgccagtccg ggagtgacgc cttgcttttt aagctcttct acctcttttg ccaattgttc 2116261 gcgtttttct ctagccgttt cttttccgtc gatgattgtt gcagtcattt tctttcctcc 2116321 tatgattgtt caatatcaga tttaatgtta gaaagaaccc cgtttacaaa ctttgtcgct 2116381 ttgtcatcac caaaccgttt tgccagctca atcgcttcgt tcatggagac attcaccgga 2116441 atgtcttcgg catatgccat ttcatatgct gccaggcgca aaatcgcacg gtcaacattg 2116501 gcaatccgat cgagcttcca attcaccaga tgcttggaga tcatttcatc cagctggtct 2116561 tggtgttcca ataccccgtg tacaagctgt tcaaagaaag gatctgtttt ttcttcatcc 2116621 agtgcgtgtt ctatggcttc attcactgca atatcgctga catcaatttg aaatagtgcc 2116681 tgcaaagctt tttctcttgc tgttcttctt ttcattttct ttctcctttg atcctcttta 2116741 tccgcttgtc gttaagccac aaagagatca taacatattt ttttcgtatc cgcatattga 2116801 aatcaaggtt tttttaccct attaccgaat attttcacac accttaatat gattattcgg 2116861 atttcacgtt catgaagaaa ctcggctatg taagccggct ttcttcatgc tttgaaataa 2116921 agggtaacgt gtaaaaaaac caaagggccg ccctcccctt ggtttcgtgt taagccattt 2116981 acatttcttc gtcgatttgg acttcttggg cttttgtgtc aaattgaatg ccgacgatgt 2117041 gaatattgat ctcgttaatc gaaagagacg tcatatttaa taaggtttga cgaatgtttt 2117101 cctgaacgga tgctgcaact ttcggaatcg aaacgccaaa tgtaacgaca cagtatacat 2117161 cgatcgtaat tccgtcatcc gccaggtcga ctttgacacc tttgccatga ttcactttgc 2117221 caaagcgctc aacgacgcct gtcgcaaagt ttccgcgcat ttcggcaact ccatcaactt 2117281 ctgatgctgc aatgccggca atgacctcaa tgacctccgg tgcaatctca accttaccca 2117341 aatgcgtatc ttcgtgatcc attttaagca agctgttgtc tttcattcaa ttcacctccg 2117401 taaaaattat gagcccatta catcatatgt ttctaaaaat ttcgtattaa actctccgct 2117461 cacaaatgtt tcgtgttcaa gcagttttaa atggaaaggg attgttgtct caatgccttc 2117521 gatgacgaat tcgctcaatg cgcgcttcat gcgggcaatc gcttcatctc tcgtttttcc 2117581 gtatgtgatt acctttgcaa tcatgctgtc atagtacggt gggatggaat agccagggta 2117641 cgcagctgaa tcgacacgga caccaagacc gccaggaggc aggtacattt taatttcacc 2117701 aggtgacggc atgaaatttt tgcttgggtt ttctgcgttg attcggcatt cgatggccca 2117761 gccttcaaat tcaacatctt cttgcttgag gctcagttcc attcctgaag ccactttgat 2117821 ttgttccttg atcaggtcag ttcccgtcac catttctgtg actgggtgct ccacctggat 2117881 tctcgtgttc atttccatga agtaatagcg ctgttcattg tagtcataga taaattcaac 2117941 tgttccagca cctgtatagc caaccgcttt ggcagccttt accgctgcat ctcccatttg 2118001 ctccctgatt tctgaatcaa gggcaggaga tggtgattct tccaaaagct tttgcaggcg 2118061 tctttggatc gagcagtcgc gttcgcccaa atggatcgta tttccgtagt tatcagcaag 2118121 cacttggatc tcaacgtggc gaaaatcttc tatgtatttt tcgatgtata cacctggatt 2118181 cccaaatgca gttgccgctt cctgctgtgt aatcttaatg ccattaatca gttcctcttc 2118241 agtgcgggca accctaattc cttttccgcc tccgcctgcg gtggctttta taattacagg 2118301 atacccaatt tcattagcaa gcgaaaccgc ttcttccaca ttttctataa ttccctgtga 2118361 acccggtacg attggcacgc cggcctgttt catcgtttcc cgcgcaacgt cttttgttcc 2118421 catttttgaa atggcgtcag cgctcgggcc gacaaacgtg acattcactt cttcacataa 2118481 ttcagcgaaa tcagcatttt cagctaaaaa tccgtatccc ggatgaatgg cgtccgtgcc 2118541 agtcagcttt gcaacactca caatatttgt aacgtttaaa tagctgtctt ttgatgcttt 2118601 cggtccgata caaaaagctt catcggccat ttgaacatga agggcatctt tatcagcttc 2118661 tgaataaaca gcgacagtct caattccgag ctctctgcag gctctgatga ttctgacagc 2118721 aatttctcct ctgttggcga tcaatagctt tttaatcatg ttcagtctcc ttactccgct 2118781 tttacaagaa atagaggttg tccgtattcg accagctggc cgttttctac taatacttca 2118841 acgatttcgc ctttcacttc tgcttcgatt tcgttgaaaa gcttcatcgc ttctacaatg 2118901 cagacaactg tgttttcatt tacttttgaa ccggctgtta catacgggcc agcttccggt 2118961 gatgaagaag cataaaatgt tcctaccatt ggtgaagtga ttttatgcag attctcatct 2119021 tgctttggtg cttcttgggc aggtgccgct gcttgctgcg cttgcggctg aactgcctgc 2119081 ggagcctgtg cttgtacagg tgctgccggt gcctgctgca tgacttgaac cgtgcctgct 2119141 tcgtgttttt tcagttttaa ggatacacct tcattttcat atacgaattc gtcaattgta 2119201 gactcgtcaa ttgctttaat cagctcgtgg atttctttga tatttaacat tcaatcgcac 2119261 tcctatgtat gaaatttctt tttttatagg ttactactaa aagtacatac tatgttcatc 2119321 ttacaggagc ggacttttga attcaactct aatatgacag caacgcaaaa agcccgcttg 2119381 tttagcgggc ttttttccct cattcttatt tagagggttc aaatgtgaca gcgacatctt 2119441 tcattgtttt gatttctttt gccacaaggt ctataatggc tgtcgccttc gatttagagt 2119501 gtttgtctga tttgactgta atattgattt tatctccttc agcattaaca agcgcatcct 2119561 cgtaaccttg tgttttaatc agcgtttcca gctgtttttc tgttccttcc acttcactga 2119621 gagccgtcat tttatcgtat gcttcgcttt tctccttggc tgttgcatca tcgcttgaca 2119681 caatggcatt cagctcttct ctttctttgc ttctggcatc ttctaaatca agacggtacg 2119741 ttgtaaacaa atcatcatcg gctgtttccg taacaacagt tcctttttca ctggcttcag 2119801 cggatgtttc cttgtctgct gatgaatctt tcgttccctt tgttccatct tcttttcctt 2119861 tttcagtttc tgtaccgctt ttttccttcg tgtcttgctt ggcaggcgct ttttcagttg 2119921 cgacctctcc gctgtcagac gcgctttttt cactttgcat ctgcacggcg tttttgcttt 2119981 ccggcgacat gatatagtag acgcttaaca ccacgacaag actgagcatt gttaatagcc 2120041 aaacggtttg ttttttaagc atttatgaat cctcctttat ttttttaggg gcaaccgcaa 2120101 cccggtggct tggaacatcc aggacccgtg tcaccgcttc gataatggtt tgttttattt 2120161 gaacgttgtc cactccttga gcaacaacga gtacaccgcg tatatcaggt tttttcgttt 2120221 ggacgacgac aggtgtttct ttatcgccgt ttttgatcat gacgatttct tcctccgatg 2120281 attggtctgt aacgcttctt tttccgcctt ctttgtcagt ttcttcagtg gttgtatttt 2120341 tgtttgattt gtttttttcg tatactttca gcgacgttgc atctacattc acgacaaccg 2120401 agacatcgtc cacaccaatg attgtttcaa gaatttcttt cagttgattt tcgtattctt 2120461 tttcatagtc atcgatcgag tctttaggtt tatcagattt tgaggcttta aacacttcgg 2120521 ctgttttctc tttgctgtct gcggaatgtt gtgatgatac ggccgttatc gttttggcgt 2120581 tttcagtttt ctcaggtgaa gaaaacagct ggctgacaag cataaaggaa actccgagaa 2120641 caaaaacgaa tagaaagtaa tgatatttgg tcagcttcgg cttttcgccg tccttcgttt 2120701 gtcccggaag aaactgcttt ttcaatacat tccataatcc gtttttattc attgccgaca 2120761 ctctccccgc cttccatatg aaccgtaatt ttctcacttc cgatttccca aatgtccgcg 2120821 agctgcgttt gtatctgttt ggcttctttt tgttcggctg cttcttttgt tacgtatgca 2120881 tgatctgtat caatgtggac cggcgcgacc gtttggaccg ttttttcaga agacggggcc 2120941 atatacacgc tgattgtttt aatatcctct tctgaatcta ccttttctcc tgccgtgagt 2121001 ttgatgcggc ctactttata ttcatcatga ctgaatctct cctccgcttt cttttttagt 2121061 tggacagcca tttcttctag aatatatgcg cgctgggaag cttgtatttc tatttttttt 2121121 gaattgattt gattttttat gtcggcagac tctgactgcc cgttttttgt gaggtattca 2121181 aagatgactt cggggtctgt cttgaaaagt ttaaaaatcg gcgtaagcat gacgacaatc 2121241 aagagcaggc tgactaccat ttttgcgtac ttttgcatgc tggagctcgg cagcagcata 2121301 tcaatcacaa ttgcaaatag gataaacaac acgatggtgg taagccattc cgttaaaaaa 2121361 ctcatttgcc tgcctccttc atttcatcat catcgtgagg tttccggctg tgattatgac 2121421 agtaaggctt aaaaaaaaca tgagagacac aatggcgaga gctgcaaaaa tataaatgac 2121481 gcttttgctg atgacgtcga ggcaggtgat gacgggcccg cctcctagcg gctgaagaat 2121541 cgcggctgcc agcttataaa taaaagcgag ggaaagcact ttgattgccg gaaatgccgc 2121601 aatacagatc aaaatagcga caccgagaat ccctaccgta tttttcagca gtaaagaggc 2121661 gctgattact gtatctgttg cgtctgtaaa cattcggcca agcacaggaa taaaatttcc 2121721 ggttataaat ttagccgtcc tgagcgtaat gccgtctgtc actgcagctg acgctccctg 2121781 aacagagatg acgccgagaa agatggtaag aaaaacagcc agtgctccga tggcgatatt 2121841 tctgagcagg ttagccagct gcgttacttt gtattgttca gtcatcgtgc tgacaatgct 2121901 cagaatcgct gataaaaaaa tcagcggcat gacgatattc tgaatcaaga gaccgctcgt 2121961 gttcatcagg aagaggataa caggatgaaa gaaggcagca gatacagctc cgcctgagga 2122021 agccaaaagc gccaagagga gcggaatgag cgccaggata aagctggtca tcgtctgaat 2122081 cgcctcagtt gcatagttaa ttgccacatg aaagctatta agcgcaagga taatcagcac 2122141 catgtacaca attgagtaag cgaccttact gacggtgctt tgctgaaaag cattttgcaa 2122201 aagctgcaga atgacgcaaa aaatcgtgag caaaatcaat gtgcccagca gctttccgtt 2122261 ggcaagcact tcatgaaaca aataagaaaa gagagctttc agccattctt gcggtgagaa 2122321 tgatttatcg ccattgataa actccattaa gctgcctttt tggctttccg gcagcagtcc 2122381 gccgtattct gtcataatgt cattccaaaa ttccccgatc ttatctgttt caagcgaggc 2122441 tgctgtcctt tccgctaatt gctcggctgt ttcagcatgg tcttccgttt gttctgcatt 2122501 accagctgct tgtacaattt ctgcacggcc tgctatgatc agcacggcca aaagcaaaac 2122561 ccattgaaag cgcttcaatc taccgcctcc tttcggttat gacatagaag gtataagtcc 2122621 gagaatcgtt tcgataatga cggttaaaat aggcacagcc attacgagta ttaaaatttt 2122681 ccccgccaat tctattttcg aggcgatggc tccttgaccg gcatcttttg tgagctgtgc 2122741 cccgaattca gcaatatagg cgattccgat aatctttaaa atggtttcaa catagaccat 2122801 gttgacattt gcattaatcg caattttttc tatcattcga ataatgtcgt agatttggtc 2122861 taccaaataa agaaaaatgg cacatccggc aaaaacgacg attaaaaacg caaaagtcgg 2122921 cttttgttct tttacaatta aagaaaggaa ggtggcgatc agccctaaac ctacaatttg 2122981 aacaatgtca atctgcaagc ccccctatcc ttggaataaa aacacagctt ttatcttttt 2123041 aaataggtca tctacaatcg tggcgaccat aaataaaata tagataaaac ctaacagcgt 2123101 cacccactga gcatattctt tcttgcccat ctgatccaat atcgtgtgta aaaaagcgac 2123161 cacgattccc actccggcga tttgaaatat gacattcacg tctactccca ttttattttt 2123221 gctcccctca cgtttacatc aatagaagaa tgagtaacaa gcccgctaaa aagcccaaac 2123281 tttttatcat cttttcgttt ttcgcttgcg cctgctcagc atccgcttct gaggcttcca 2123341 aatgtgtcag cgccagcttg atgtgctttt gctgagagat tcgatcatga atcccaagcg 2123401 tctcgccaaa ctgcttcagc acttcgtatt cgcttttttt caaagacagg gtgtcccata 2123461 ccttctttaa gctttgctcc cacgccgttt tcgcggaatc acttcccttg tccagctgat 2123521 cactgaatgc ggaaaaaaga gttgaaacag gctgtgcgag ctgtttggca atctgctgtg 2123581 aagcagtatg aagcggtgta tggccgtaca tgatttcagc ctcgagggat tgaagcgccg 2123641 cacgcagctg gcggatttgc cgcggccgtt ctgtataaat cttcgccatc tcaaaacctg 2123701 tccatgttgt cgctaccaca atgaatacag cgcccagcag cttcagcatg ttttcacgcc 2123761 cgtcgtccta gacagcacat ttccgtcttt gtcataaatt tggctcactg tgcccggccc 2123821 ttttgctctt gataattcca aatagcggtc aaaggctctt tcttcccaca aacgcttcaa 2123881 tgaaggccgc ttcatcaggt cggatatact ccagccatgc gccgatacga ttactgaaac 2123941 accggcatgc agcgcctcca gaagtgcatc tgtatcttcc atacgcccga tttcatcgac 2124001 aatcatcacc tcagggctca tggatcgaat catcatcatc agcccttcag cttttggaca 2124061 ggcgtctaac acgtcaattc tctgaccaaa ttgatgctgc ggaataccgc gaagacatcc 2124121 ggcaatctct gaccgttcat cgacgatccc tgtctttacg ggcagcatgt tttttttgcc 2124181 ggtgcttgag agcctcgcaa ggtcccggag aagtgttgtt ttgccggttt ggggcggtcc 2124241 gataatcagc gtattcagcc agctgttttg atataagtat ggaagcagcg gctccgcaat 2124301 ccccagcttt tgccgggcaa ttcgtatatt aaaagatgcg atgtcacgga ggcctttcac 2124361 acctccgttt tccgtaatga ctctgcccgc cagtccgact ctgtggccgc ctctgatcgt 2124421 gacataccct ttcttcagct cttcttcaag tgtatacata ctatagttgc tgagccggct 2124481 caggatcaga tgggcatcct cggccgtgcc cgcataggac aaataaacag gttgtcctct 2124541 tcgaatcaat tcaacagggc ggttgatccg aattctgact tcttcgattt ccagccattg 2124601 ttgttccggt atttcagaaa gggcgttttt catggattca gggagaacct cagcgatttc 2124661 attcaacaga gcctcctcct ttctaccgat tggcttcttt aaaatgtatg atgtgaggca 2124721 gactttatga caagcctctc tttatttatg aacacccgcc aaaatcaaga caacacccgt 2124781 aaaaatcaga atcagctttg catacgaaag ctgcccggca atttggtaga ttccgacagt 2124841 cattgtaatg ataaaaatca acggaccgac aatagcgaga atgctgttaa ccacaaccgc 2124901 cttccggaca tcgttggtca caagcatgac aattgctgcc gtcagctcaa tcatagagga 2124961 taaaactcgt aatcccgcca ttgttaaaac agtagaattg atatttccaa gtaaaaattt 2125021 catagcactc tcccaacctc ccattttttt atatgatatg ctctagcttg ctgaagtagt 2125081 cttgtcattt tcgtataaaa gaaagattct gtttttgggc acaaaaaaag cctgctccca 2125141 tttgggaaca gacttctttt tttctttcta tgctcttgaa acgtaagaac cgtctgatgt 2125201 attgacaaca agtgtgtcgc cttcattcac aaagaacggc acgtttacaa caagcccggt 2125261 ttcagttttc gcaggttttg taccgcctga cgctgtatca cctttaatac caggttcagt 2125321 ttcaacaact ttcagctcaa ctgtgtttgg aagttcgata ccaagtgttt catcctggta 2125381 catcatgata tgcacagaca tgttttctag caggtatttt aattcttctt cgatttgagt 2125441 tgcgctcagt tcaagctgct cataagaaga agtatccata aatacgtgct gatctccgtt 2125501 tgcatataga tattgcattg ttttggtttc gatttgcgct ttcgctactt tttcaccagc 2125561 gcggaatgtt ttttcctgaa tcgcgccagt gcgaaggttg cggagtttag agcggacaaa 2125621 tgccgcacct tttccaggtt ttacgtgctg gaagtcaacg acgcgccaaa tgccgccatc 2125681 tacttcaatt gttaatcctg tacggaaatc gttaactgaa atcatgttta atgtcctcct 2125741 atattccaat cacaaaataa taagttcttt tggggaatgg gtgattgtcc ggttgccgtt 2125801 ttctgtaatc acgatgtcat cttcaatgcg gacaccgcct gtttctggta tgtaaatgcc 2125861 cggctccact gtgaccacca tacccggttc aaggatagct gaagatctga cggataatcc 2125921 cggcgattca tgaacttcca tgccgagccc gtgcccggtt gaatggccga aatagtcacc 2125981 gtagcctttt gcagcaatat gatcccttgt gagggcgtca gcctcttttc ctgtcattcc 2126041 cggcttaata tgtgcgacgc caagcgcctg agcatcaaat acaacctgat agatctcctt 2126101 caattgatca ctgggctgac ctacagcgac cgtccgggta atatcagaac aatatccttt 2126161 ataataagcg ccaaaatcaa gcgtaacaag gtctccgctt tcaatcagtt tgtcactggc 2126221 cacaccgtgc ggaaggcttg aacgaaggcc tgaggcgaca atcatatcaa aagaagagct 2126281 gtctgctccc tggcttctca tataaaactc cagctcattg gcaacagcga tttcagaaat 2126341 gccgggtttc ataaacgtca agatatgtct gaaggcatca tctgcaatct tcgcagcttc 2126401 ctctaatatc ttaatctctt cactagactt aatcaagcgc aacttttcca cggattcagc 2126461 cacaggcact aattcggcat cactgataac ggcgctgtat gaagcgtaag tgccatatgt 2126521 catgctgttc tgttcaaagc cgagacgctt gatgccaaac gattcaacag tgtcggcagt 2126581 ggtctgaatc aagctgccgc catgttcaat gatctcaaaa ccctttacct gaaccttcgc 2126641 ctgctcagta taacgaaaat ccgtaataaa cgctgctttg tcacccgata taacagccaa 2126701 acccgccgaa cctgtaaacc ctgtcatata gcgtacatta gtgttgcttg taatcagcat 2126761 gccgtcaatt cccagctgtc caaacaggtt tcttaatttc tctagcttca tcttgattct 2126821 cccccttgct ggcttaataa gtagcgaaca gcaagcttgt agccttcagc tccaagaccg 2126881 acaatctgcc ctttcgcaac aggagcgata accgactgat gcctgaattc ttccctggcg 2126941 tataagtttg ataaatgcac ctctaccaca ggaagactga tgcttgaaac agcatccctg 2127001 atcgcatagc tgtaatgact cagggcgccg gggttcagaa caatcccgct gtattgctcc 2127061 tcagcctcat gtatcgcatc tatcaaatca ccttcgtgat tagactggaa gaaagtgagc 2127121 tggatatgta aggcttcagc aaactgaaaa agatctgttt caatatcggt cagtgtctgg 2127181 cggccgaata cttcaggctc acgactccca agccggttaa cattcggtcc gttcaaaatc 2127241 aaaaaatgag gcacacaatc tctccttttc gcgagggttt ctcatgtaaa aaatgttcac 2127301 ttctcgtgaa cattttatca tactggaaaa ggattataca ctattctcta tgcattccca 2127361 gcgcacgtgc aagcttttcc gaattcagct cattgtattc aaatgaaata gaatacccga 2127421 caaacagccc gtaaagcaaa taaatgcaaa tggtcgtaat aattgtatct gatgtcagtt 2127481 cggtcaccgt gcgcacatct ggaaaaatcg gattaaaaac aaaaaacacg agcagccaaa 2127541 gcaccaagcc gtataaaata cccggccaca ttgtttttaa acgtttcaat agaagaaaat 2127601 aaagaaatgc tgcgccaatt gaaattactc caatcaaaat gatgctgatt accgttccca 2127661 gcccatgttt tttccactct ccgagtacaa acggctgcaa tatcatattc gggctgattt 2127721 cggaaaaatg aaacaaatat gcgatataag caacgaaact ccaaagtacg cctccgcaaa 2127781 aacctgttgc cgccaccctg ccggccattg aaacaggcgg cttttgcttc tcattcaatt 2127841 cttcattttg ttctgtatct ttttcgcttg tcatcatggc acctccagtt aaagtgtgcc 2127901 caaaaaatga aatgtcaata aaaaagctca cactttttgg cagctgcgag taaaatttga 2127961 aaataacggg tataatgcat gtagaaaaag caaggctatg gcaatttttt cagcctgtca 2128021 atctagaggt ttagcgctgt ttcctgtaca atagagtgaa aggaaatggt tagcaatcct 2128081 aaagaaatag gcaggttgat aatatgtcaa aacataaagt tccgcccgct tacggcgggc 2128141 aggctgttgt ggaaggcgtt atgtttggcg gaaagcatca ttacgttaca gccatcagaa 2128201 gaacggatgg aagcattgac ttttttaagc ttccacgcaa acacaacccg aaactgaaca 2128261 tcgtgaaaaa gataccgttt ttacggggga tcgcggccat tatcgaagcg agtgcaaacg 2128321 gcacaaagca tttgaatttt tcaagcgaac gttacgggct cgatccatct gaagacgaga 2128381 cacttgagca ggaagaaaaa aaatcctctg ggctgtctat gtatctcagc ctcgcagtta 2128441 taggcgtcct atcatttttg ttcagtaaat tcgtatttac attggttcca gttttcttag 2128501 cggaactgac aaggccgatt ttttccttga acacagcgca aatcgcgatt gaaagcctgt 2128561 ttaagttgat tttgctgctc ggttacatct attttttgtc catgacaccg cttattaaaa 2128621 gagtgtttca atatcatgga gccgaacata aagtcataaa ctgttatgaa cagaatttgc 2128681 caattactgt ggagaatgtc caaaaccaat ctcggcttca ttaccgctgc ggatcaagct 2128741 ttattttatt tacgattatt gtcggcatgt ttgtttattt actcgttccg acagatccgc 2128801 tttggctgcg tgttatagat cgtgtcgcac tgataccggt cgtgcttggt atatcctttg 2128861 aagttctgca gctgacaaac aaagtgcgtg acattcccgg tctgaaatta cttgggtacc 2128921 cgggactttg gcttcagctg ttaaccacaa aggaacctaa ggatgaacag gttgaagttg 2128981 ccatcgaaag ctttaacgaa cttctcagac tcgaagcatt gtctgagcaa aatcagaagc 2129041 cttctcacaa cgtcatctaa aatccgttgc cctgctatta ctttcggagg tggacagtta 2129101 tgaatcatcg tgtacaacct attattgctg tattaattgc gctgggagcg ttcggtttcc 2129161 tctatgtgct ggtaaccaat cccggagaaa tggcaaaaat ggcggtaacc gtcatcgtgg 2129221 caggtatcat tatttatttt attgtgaaat atgtaatgaa tcgaaatgcg ggcagcgaag 2129281 gagcagcctt caaaaaagcg gcgaaacaat cacggcgccg gatgaaagaa caaaaagcaa 2129341 aacaccgcgc cggacataag ggacgtgtca gccacctgcg aagcgttccg agcgccagca 2129401 agcctaagcc gatgattctc aagaaaaaaa gccagactca gctgactgtt atagaaggga 2129461 aaaaaaataa aaagaaaaac agagcgcttt tttaataggt ccactgcttt aaaaacagct 2129521 ctgtccgtct tttacctagc tcaatcaggg ctagtttttt ttgttgtgtt aaatgaaaat 2129581 cagtggccat tacgtcatca acagggagaa aaatgatatt ttgttcatag cgtgacgcaa 2129641 tgtgccttgc gtcatgagca tccttcatcg tttcaaacag ggcgccgaac agttcaaaag 2129701 cgttgcggat attttttttc ggacgctctc tttcacgcgg cgcaagcgtg acaccgatca 2129761 cagggcgctt tctttccttt gaaaacagcc agattggaaa attgcttaac acgcctccgt 2129821 cgacaaccgt ggcggtgcct gtgtccgttt ttaattttat cggttcaaag aaatacggaa 2129881 tgctgcagct cattctgacc gctctggcaa ccgggaacat atctggattt aacccgtaac 2129941 gggccaaatc gtccggcaaa acaatcatgg tgccgtttgt cagatcagaa gcaataaggc 2130001 gcagagaccc tttctgcaaa tcgccgaaaa cccttatgcc tttcgctctt aacagatcag 2130061 caatccattt ttctatcgta tcgcctttgt ataagccaag acgccagtag atggacaccc 2130121 actggagcat ctttaagggg agaaatgagt acctctgatc cagcaatttc tctccgtcca 2130181 cttcttcaat taaagcgtgg atttccttac tggtgtaacc tgacgcaatg aaagcggcaa 2130241 taatggcgcc ggcgcttgta cccgcaactc ttttaaagcg gaagcctttt tcctcaagca 2130301 cttcataagc gcctgcgagc gcaatgcctt ttactcctcc gccggaaaac acaccgtcaa 2130361 tatacatctc attccctccc cctccatccg atcgtttatt accattttaa gaaaacacgc 2130421 gaagaaatag accaacgaat gacgggtggc gtcagcgtat caaaaaagac ggcctccttc 2130481 gagaccgcct ttttactgat tatgatgttc tgttttcttt tggattgatt tcagatcttt 2130541 tttacgggca tcatcttctt caaaatattg aacaagatcc ccgatgcgat caatactgtt 2130601 ccagcttaaa tgatgttcga ttccttcgac atcgttatat attttctctt catcaacacc 2130661 aatgattctt aaaaactgct caagcaattc atgtctgtat accagccgtt tgcctatttt 2130721 tttcccttta gacgttaaca cgagaccgcg atatttttca taaattaaat attcgtcttt 2130781 atctagtttt tgaaccattt ttgttacaga ggagggatgg actgccaatg cttccgcgat 2130841 atcggaaact cgtgcatatc ctttttcttc aatcagcata taaatctgtt caatataatc 2130901 ttccatactt ggtgttgtca tcgaaaccct cccaaaaagc accttaactt tataaaccat 2130961 tacaagttta cactaatgaa cttgaaaaaa caaggatgct ccgcgggtca aaagccctgt 2131021 ttaccgctta taattccatt catctgaagc gtactttgtt tcagccaagt gatgaacaaa 2131081 atcaagctct tcctgagaaa gttcatatgg ctccaaatga atgttaagac ctgtttcaaa 2131141 tccttcttta aaggctttac gagcctcatc catcgtcacc cgcttttcga tgagttcatt 2131201 aatggcaacc gctttatttt tgaaattgcg ctgcatccgc tctcttactc tttcacttgg 2131261 atataagaac agatcgaaca gcttgtcctc atctaaatca agaagaatgg agccatgctg 2131321 aagaatcaca cctttttgtc tcgtttgcgc gcttcccgcc accttgcgcc cctcaaccac 2131381 tagttcatac cacgaaggcg cgtcaaaaca aacagatgac cgcggatttt ttaagctttc 2131441 tttttctttt tcagttctcg ggatggcaaa gtaagcgtcc agaccgagat ttctaaagcc 2131501 ttgaagtatg ccttctgaaa taacccggta agcctcagta acagtcgccg gcatctcggg 2131561 gtgctcttcc gaaacaatta cgctgtatgt cagttcctga tcgtgcagca cacctctccc 2131621 gccggtcggg cgtctgacga atccgagatt atatttatgt actgcttcaa aattgatttc 2131681 ctttttaata ttttgaaaat accctacaga aagtgtcgcc ggattccagc cgtaaaaacg 2131741 gataaccggg gggattttct tttcgctgtg ccaatataaa agcgcttcat caagcgccat 2131801 attgaatgca ggacttgcat tgcctgagtc tataaaccgc caagtttctt tttgcatttt 2131861 aagaccttcc ttaccgtttt aatagaatca gtttatcaaa ctgtcgggaa aatgaaaaat 2131921 attttagttc cattatagat gacaatcacg ctgtgcttta ctataatagt atttgtcgaa 2131981 aacggctcta tgaccttgtt ttatgaagca gggttttgat tttatatgct aaaggagtag 2132041 aatcacattg tctaatatga tcgttttgat tatttttgct gcatttatca tctatatgat 2132101 tgcttcatat gtctatcagc agcgaattat gaaaacactt accgaagaag aattccgcgc 2132161 gggttaccgc aaagcgcagc ttattgatgt tcgtgagcca aatgagtttg agggcggaca 2132221 tattttaggc gcccgcaaca tcccgctttc ccagctgaaa cagagaaaaa atgagatccg 2132281 tacggacaag cctgtttacc tgtactgcca aaacagtgtc cgcagcggac gcgcggcaca 2132341 aaccctgcgc aaaaacggct gcactgagat ttacaaccta aaaggcggct ttaaaaaatg 2132401 gggcggaaag attaaagcga agaaataaag caaacagctg tctggtagac agctgttttt 2132461 atttatcttt cttccgcctc gtatctgagc actgggtgtc tcgccgcttt tgtttcatcc 2132521 attcttttta caatcgttgt atgcggggcc tcctgaacaa gctccggatt ctcctccgct 2132581 tcttttgcga tttgaatcat agcatcaata aacgcgtcca gtgtttcctt tgattcggtc 2132641 tctgtcggct cgatcatgat gcattcttca acattaagcg ggaaataaat cgtcggcgga 2132701 tgatagccga aatcaaggag ccgttttgca atatcaagcg tacgcactcc cagctttttc 2132761 tgccgcttcc ctgataatac aaattcatgc ttgcaatggc ggtcaaacgg aagatcgtaa 2132821 taaggcgcga gttttctcat catataattg gcgtttaaca ctgcgttctc agtaacagcc 2132881 tttaatccgt caggccccat ggagcgaata tacgtatacg ctctcacatt aatgccaaag 2132941 ttgccgtaat acggcttcac acggccgatc gcatgagggc ggtcataatc aaacgtaaag 2133001 cgcccttctt ttttgactaa aactggcttt ggcaaataag gaatcagatc ttgttttacg 2133061 ccgacagggc ctgagccggg gcctccgccg ccatgagggc ctgtgaatgt tttatgcagg 2133121 ttgaggtgca ccacgtcaaa tcccatatca ccaggtctcg ccttgcttaa aacggcattt 2133181 aaattagcgc cgtcataata cagtttcccc cccgcttggt gtacaatttc cgccatctct 2133241 gtaatctgct cctcaaacaa gccgagcgtg ttcggattcg tcagcataag agctgcagtt 2133301 tcttcattca ctgctctttt taaatcctct aaatcaacaa gccctttttc attcgatttc 2133361 accgtaacgg tttcaaagcc tgctactgtt gctgatgcag gattcgtccc atgcgcggaa 2133421 tcagggacaa tgaccttcgt ccgcttgaaa tccccgcgag cttcatgata ggcacggatc 2133481 atcatcagcc ccgtccattc gccgtgcgct ccggcagcag gctgaagcgt aacctcatcc 2133541 attcccgtta tttcttcaag gtgtttgctt aaatcatata aaagctctaa tgcgccttgc 2133601 accgtgtctt catcctgaag aggatgaatc gcagcaaaac caggaatacg tgcgattttt 2133661 tcattgattt tcggattata tttcatcgtg caagaaccga gaggataaaa accggaatcc 2133721 accccgtgat tgcgtttgga cagcgctgta taatggcgca tgatgtccag ctctgaaacc 2133781 tccggcagcg ctgcgtcttc gtcacgaata taggtgtctg acaagaggtc ccccaattcg 2133841 atttccggta catcgagctc cggcagacta tagccgattc ggccttctct tgaaagttca 2133901 aaaataagtg cctggtcctg attactcatg gcgatccccc aattcctgaa tgagtgcgtc 2133961 aatttcttct tttgttctca gctctgttac agcaatcagc atatggcagt ccagctctgg 2134021 atacgtcaac ccaagatcat atccgccaat catgcctttt gccagcaaac gcttgttcac 2134081 agctctcacc ggctcatcca gtttgatgac aaattcatta aacatcggcc cgtcaaacat 2134141 aacagtaagg cctgcttttt ttgcttcttg ctttgcatag ttggctttta agagattttg 2134201 gcgggctata tcttttacgc cgttttttcc gagagcagtc atggccactg atgctgccag 2134261 cgcatttaaa gcttggttcg agcatatatt tgatgttgct ttatcccggc ggatatgctg 2134321 ctccctggct tgcagggtaa gcacaaagcc tctttttccg ttttcgtctt ccgtttgtcc 2134381 gacgagacgg cccggcacct ttctcattaa ttttttagta acggcaaaaa agccgcaatg 2134441 cgggccgccg tatgctgaag gaatgccgaa aggctgcgca tcaccgacga cgatatcaga 2134501 ctgaaacttg cccggcggag tgagaagacc tagcgccagc gggttggctg aaacaataaa 2134561 catggatttc ccttgatgag cgataggctc aatatccttt agcggctcga tcctgccgaa 2134621 aaaattcggg tactgaacga tcactgcggc tgtgttctcg caaacggttt ggcgcaatgc 2134681 atcaagatcc gtaacgccat ccgcagcggg tacttcaaca acatcaatat actgaccttt 2134741 tgcgtaagtt ttcagcacct ctcgcgattc aggatgcacg gtttttgaca caacaatttt 2134801 tttctttttc gtgtggcctg aagcaagcat tgctgcttct gccaaggctg ttccgccgtc 2134861 atacatcgag gagttggcga tatccatgcc tgtcagttca cagatcatcg tttggaattc 2134921 aaaaatagcc tggagctctc cttgtgaaat ctctggctga taaggcgtat atgcggtata 2134981 aaactcagag cgcgaaatga catgatccac aatgacaggc tgatagtggt catatacacc 2135041 cgctcctaag aaagaagcgt attgtacggt atcacgattt ttagaggcca gctttgtcag 2135101 ttctcttgtt aattctgtct ctgatttcgc ttttttgatt tgatgctctt ttttatattt 2135161 gacgttttcc ggtatatcag caaataaatc atcgatgctg cttacgccga tagtagcaag 2135221 catctcctgt ttatcctttt ctgttgcggg caaataacgg tgcttcatgt gttgtctcct 2135281 ctctccaaga aaaaatatta gcgtttataa aatggtgttt tgacaacctt tgctttcact 2135341 aattttttgc gtatctctac atctacaaca gtcccgatct cactcgtttc cgaatcaatt 2135401 aaggcaaggc cgacgttttt tcctaatgtc ggtgactgcg tgccggttgt cacctttccg 2135461 acagacttgc cattttggaa aacctcatat ccgtgccgcg gtatcccttt ttcaatcatt 2135521 tcgagaccga caagtttgcg cttcgctccg ttttcttttt gttcactcaa tactgactta 2135581 ccgaaaaagt cagactcctt tttgtgcttt acagcaaagc ctatacctgc ttcaatcggt 2135641 gtaatatccc gggtcagctc ctgaccgtag agcgggagct tcgcttcaaa ccggagtgta 2135701 tcacgtgcac cgagaccgca tggaatcaat ccgtatgcat cccctgcatc gatgattttt 2135761 ttccaaatat gcatagcatc atcactgcgg cagtaaattt catacccgtc ttctcccgta 2135821 tagccagtgc gtgaaataag tgctttgcgg ccgctgatat cggcttcatc aataaacgca 2135881 aacggcttta atgcagacac atccgcatct gtcagatttt ttaagatcgc ttctgctttc 2135941 ggtccctgta cagccaagag cgcgatttga tctgactgat tgtcaatctg cacatcacct 2136001 gctgcatgtt ctttcatcca agccaagtct ttatctatat tagaagcatt aatgacaagc 2136061 agatagcggt tctctccttt ttgatagata agcaaatcat cgacggttcc gccatccggg 2136121 taacacatcg ctgtatattg agcacggcct ggcgttaacg cggaaacatc atttgtcatc 2136181 aatctttgca aaaaagacag actgtcgttc cctgacactt cgacttctcc catatgagat 2136241 acatcaaaca aaccggctgc agttcggaca gcctcgtgtt ctttttttat agaagaaaat 2136301 tgaacaggaa gctcccagcc tccgaaatca atcgtttttc ctccatattc cttatacagg 2136361 tcaaataacg gcgttctttt cagcatctaa ttcctcccct ttatcaacgg cgcagctaaa 2136421 aaacatacaa aaaaggacag agaaacacct catgtaaaat gaaggttctc tgtcctggca 2136481 cctgaaagtt tactttgcat acgcaaagac gtcccctttg gtggtttgcg catccgcaca 2136541 aacactctcc agagttgcgt cgagcaagag ttcttttgcc tgagagattc actccgcagt 2136601 ttgctccttc ggcgcctgta tcccgaggtt ttcggtcagg tctctcccct tgctgtcatt 2136661 cgctcatatt ttcatgctgt tatggacata ctatagcaat atcttacatc aaatacatac 2136721 tcatatccta ccatcatcac tatatgctgg gcaacagcaa tttgggcaga tttttcttat 2136781 attattcatc ttaagaatcg aagaataaga aaggcggttt caaagcaatg aatacagaaa 2136841 tgatctacga tgcaaaatgg cctgaagaat ttgctgaaag actgaaaaac gatggccctt 2136901 gggcaaactg ggaactgtac aagctctctg cagaaatcca gaaaacatta gcaattccag 2136961 agtttgaagg cttacgggct cctttatatc tgccttcctt tacgccgctc ccccaccagc 2137021 ttgaagtggc gcaaaaagtg gttgaaaaaa tgaacgggaa agcgatttta gcagatgagg 2137081 ttggtctcgg aaaaacggtt gaagctggac tgattctaaa agaatatatg attcgcgggt 2137141 tagcaaaaaa aattttgatc cttgtgcccg cttcccttgt gtcacagtgg gtcaaagagc 2137201 ttcaggaaaa atttttgatt ccggctgttg aacaaaagaa aagctatgtg tgggagcaat 2137261 gcgatattgt cgtctcatca atagacaccg cgaagcgctc gccccatcga gaaatcgttc 2137321 tgtctatccc atatgatctt gtcattattg atgaggcaca caaactgaaa aatagcaaaa 2137381 cgaagaacta tgaatttgtc cggaatctcg taaaaaaata ttgcctgctt cttaccgcga 2137441 cgccaatcca gaaccgtatc gaagagattt tcaatttggt gtccttatta aaacccggcc 2137501 atttaggcag tcagaatcac tttcaggagg agttcgccaa gaagaaatcc agtttagaag 2137561 cgcatgaaca tttaaaagat cttgtgaata aagtcatgat ccgtaacagg cggcatgata 2137621 cagggctgaa ttggaaacag cgccatgttg aaacagtgcc gattcaattt tctccatcag 2137681 agcaggcgct ttatgatgaa atttctcgtt tgaaggacag tatcaataaa ccagccagca 2137741 tgttctcgat tatgaccttg caaagagaat gctgttcgag cagagaagcg gtatatatga 2137801 cgctgaaaaa gatgcttgat caaaaagaga aacaagcacc tgccattgat gaggatacga 2137861 tttcagtttt gatagatcgc atcaatcaag tgacacaaaa ctctaaagcg cttcaagttg 2137921 ttgacttgat caaaaagatc gacgataagg tcatcatttt tacagaatac cgcgcaaccc 2137981 agatttatct gcagtggttt cttcagcaaa acggcatcag ttctgtgccg tttagaggcg 2138041 gatttaaacg tggaaaaaaa gactggatga aggatctttt ccgcggaaaa atccaagtcc 2138101 ttattgcaac tgaagcaggc ggtgagggaa ttaacctgca attttgcaat cacatgatca 2138161 actatgacct gccatggaac ccgatgcggc ttgagcaaag aatcggaaga attcacagac 2138221 tcgggcagga gcgtgacgtg catatttata acatggcgac aaaacatacg gtggaagagc 2138281 atattctaaa gcttttatat gaaaaaattc atttgtttga aaaagtggtc ggtgaacttg 2138341 atgatatttt aacgaaaatt caagtgaaca attttgaaga gcaccttcat gacattttgt 2138401 atcactcagc aacagaagaa gaaatgaaaa taaaaatgga taacttaacc tcatttttgt 2138461 cttataaaaa acagctgcct gctgaaaaaa gaggatctta gcctgtaagg aggttttatt 2138521 agtgagacag caagaggttc acgattttct gctgcgtttt tttcaagcaa acagctgcca 2138581 aatcgtcgat caaggcttag gctatatgac agtgcagctt acagttgaaa tggacaaaca 2138641 aatcatgaac cgccctttct actggcattg gcgcgagaag acaggcggtg atccgaatcc 2138701 aatgaaaatc acttttatta cagataaaga aaatgcgcca aaagacctag atggtgaatt 2138761 tatatatttt ggggccccgc gtctttttca aatattcaaa gctgttaaac aaaatgggag 2138821 atttaccaga atgtatgaga aaattgaatc agccggagct aaagtcccac ttcagccttg 2138881 gcttggtata aatgtcacga tttcatacca gtccgacatg aaaaaggata agttattgtc 2138941 actaggtctt cacctagtct ctggaacgat aattgaagat tttcaaagca agctgaccca 2139001 gttttcactg acgtctcaaa tatgtgacta ttgcttcacc atttcaccta tgatcaaacc 2139061 agaaagcgga cttaagcgta tggaaaacta tatttccaaa tccgctatgc aggagccgtc 2139121 cgactgggcg gaacaggcgg ttaacaggtg gaagaatgat atgacattgc ttgataagtt 2139181 ttacgagcat atagaagaaa aaccagaaga ataccatcta gaaaaacagg cgctgaaaac 2139241 cttgtatcaa ccaaagatat cagttgaaat tgaaaatggc ggattgtttt atctgcaaaa 2139301 taatatttca agctaacttt tttaccattc gacatcattc tcgttttttt tgagaaaata 2139361 cgattataat aaaggtatat tggaaaaaaa ttctggtgat ttaatggcaa atgacttcca 2139421 gagactaatg aagcatacaa taagtcatgg ccggactggc tgaaatacat aaacaagtat 2139481 tttaggagga gaaactgcat gaagaatgca aaacaagagc actttgaatt ggatcaagaa 2139541 tgggttgaat taatggtgga agccaaagag gcaaatatca gcccggaaga aatacgaaaa 2139601 tatttacttt taaacaaaaa gtctgctcat cctggtccgg cagccagaag tcataccgta 2139661 aatcctttct gaatgtgcta taatatcaca aggaaggtga tgacattgat tggccagcgt 2139721 attaaacaat accgtaaaga aaaaggctac tcactatcag aactagctga aaaagctggg 2139781 gtagcgaagt cttatttaag ctcaatagaa cgaaatctac aaacgaaccc ctccattcaa 2139841 tttctcgaaa aagtctccgc tgttctggac gtctcggttc atactttgct cgatgagaaa 2139901 catgaaaccg aatacgatgg tcaattagat agtgaatggg agaaattggt tcgcgatgcg 2139961 atgacatccg gggtatcgaa aaaacaattt cgtgaatttt tagattatca aaaatggaga 2140021 aaatcccaaa aagaggagta gtgcctgagc agaggcacta actcctcttt tgtcaataac 2140081 catcgagacg gcccagtata tgaatactgg gccgtctctt ttttttgctg ttattaattt 2140141 ttatcctcgc tatgcgcgag ctcgtcttgc tcagtattgc tcattttttc aattttttag 2140201 aaatttttgg gattgttatg tgagaattta aatgcatatc ccattattat ttggtaataa 2140261 taaacaaaga aagggtgaca gcatgatgat caaacaatgt gtgatttgtc tatctcttct 2140321 cgtctttggc accacagccg ctcacgcaga agaaacaccg cttgtaaccg cccgccacat 2140381 gtccaaatgg gaagagattg ctgtaaaaga agcaaaaaaa aggtacccgc tcgcacaggt 2140441 actgttcaaa caaaaagtat gggaccgtaa aagaaaagat gaagcagtga agcaatacca 2140501 tttaactctg agggaagggt caaaagaatt cggcgttttt gtgacgattt catttgatcc 2140561 ttatagccaa aaggtcaata aaattgccat attagaagaa tatcaataag gtcctccatt 2140621 ttttgaagga ccttattcgt ttatttgcgg ttattttttc cgtttcagcc aaagtcggaa 2140681 gccatagggt aaaataccga accactgctg ggaaacaggc gtttttgttt ctttccgcac 2140741 ctcttttcgt tcttttcgct catctctcgg agtatctata tatttgacaa attgctgcgt 2140801 catatattta acataatcat tcgttttcac gtgatcacct catcattcaa ttattatgag 2140861 tgttgtctca catgactttt tttataccct ttacactgtt ttattctgtc catctcagca 2140921 gttttttctg tttttggtca aacacgatct gtgcagttct ttctgttccc gaatccgttg 2140981 acactcttaa gttgatttct ttttgttctt ttatcgatgt atcatgaatg taataagaaa 2141041 cccgtccata tagaaattgc tgcgtaccct cctggccttt ccgttcctct agaacatgcc 2141101 gaatcgaaag aagcacccca ttttgaagca aattctctcc tatgtataac tcttttgttt 2141161 ccttctcaaa catgcagcgt gaaatatatt gagcagcaac aaagttcacg attaacagca 2141221 caagcgctga cacaaaaaga acagctggat aaataaaccc tcttgtacga tacattcacc 2141281 cccctcctaa atacgaatag actggaaaag cagtttgata cactttttgg tcttcactct 2141341 caattttcag caaaacaaca ccattttcaa tatcagcttt catggcagta atatgatcta 2141401 aaatcggaac atgccctttg ccatccactc tttttcttat cattgaatga taaatgtcaa 2141461 aacggatgtc ttgtccggaa agattggtgc agattaacac gctcccatgc tcggctgtct 2141521 taactgcctg tgattccttg cattcattca tcatctgttc tatcgaaatc atccattcct 2141581 gctgtgtgaa accgtcatgt tcctgctgtc gagacaaaaa cagatggata atcgcagcta 2141641 acgatcctga tatgagcaaa aagactgaga gcgaaaataa tacgttaaga agcgtgtagc 2141701 cattctgtct gcaaaatgct gaggcaaaat gatttttctt tataagctgc ggctttgata 2141761 catacgtttt gatattcgcc ctcctcctcc cacttcattg catagatatg attgttcttt 2141821 gtaatcgttt ttgacgcggc tccttcacca ctcatgacat atttgctaat gctctcattc 2141881 atcatctgat agccaatttc tcgtgattcc gccatttttt catcagccat cagcttgtcc 2141941 cacaagggga cgactgtcag cagcacaaac agccacaggc ttagcgcaga cattgtttct 2142001 attgtagaaa aacctttatt ttctctccac attgactctc ccgctcccta gataaactgt 2142061 tatgtcataa acggcatggc cttttactcg tatttttccg cctgcattcg ggtgcccttt 2142121 ctcattaaat tccaaacggt cttttaatgt cagcagttct atagaaagtc ccgttgcata 2142181 cggacgttca ataaccgtat caccaatgac taattgatat tcttttttat gaaagagaat 2142241 ttttgttctt tgttgacggg aaatagcagt ctgctgtgtg agcataatat catttttcag 2142301 ctgacttgct gcctgtcgga cagctgtatt gtcataagca ggaggaagtg tagtgaagac 2142361 ggccaccagg aggatagagg caaggcttaa cacaagcaaa ctttctaaaa gggtaaaccc 2142421 cttctcctcg tttaatttaa tgttcaacct taacttctcc gccggtgatg ataatgcgct 2142481 taccatttgg acagacagca tcctttttca catagccctc tgactgtaaa tcggcaaggc 2142541 tcggagtttg tccttcatga tcaagctcaa atgcagtcat ttgtgcctta accatgtttt 2142601 gtaagccttc acagcccttt ttttgaatgg tttgattatg tttcgtgacg ttcggtatcg 2142661 taattaaaag caaaatcgaa ataataaaga gcacgattaa catttcaaca agtgtaaatc 2142721 ctttctcatt catcagcctc ttcctttcac atttgattca tcatctgata cataggcaca 2142781 agcatagata aatacacaag taagatcatc gctgcaacaa atccataaat cattggctga 2142841 aggatgcctg tccatttttg cgctttgtgt tccagccgct gtaatatgaa ttggctgtat 2142901 gtgaaaagct cccgatccaa tcggccgctc agctggccgt gagatatgac ttttgataaa 2142961 tcagtttcat aaaaaaggct tccacaaata gcggattcaa ttgactcacc ggcttttagc 2143021 cgttcaatca attgttcagc ctcgcagcgg tagaaaggga gaaacgtttg atgtttaaat 2143081 gcattaaggc tgtcataaat tgagaggcct gattttaaaa ggctgcttag ctgcaaagaa 2143141 aaaaagtagc tgttaaacag ctttacaagc tttccaacca aaggaatcct gatacaaatc 2143201 agcatttgcc gggcaggtga ttttttctta aacacaagcc aataataaat cccgatacct 2143261 gctgtaaaaa gaacaagcaa aatgatcaca agatcaatat gctgaaaaaa agcaaaaagc 2143321 atatcggttg aacgtgaggt ttccatattc atcgattgat agataccgga aaactgagga 2143381 atgatgatgg actgtaacat ataaaacatg acagcgaccg taaagatgag gaaaagcgga 2143441 tagcgcagca ctcttttcag ctggtctgcc tgtgcaattt ttcgttccag cagctctccg 2143501 ctctggatca ttgaagcagg cagttcacca tgtgtttcag caaaataaca aatacctacg 2143561 gcttccttat gaaatgacaa actctttagt acttgataaa acggagcccc ttccctcaaa 2143621 caagtgaccg aatcagtcaa gtcagccgcc tgcctcttat tcatctgaag ttccatcagg 2143681 cgtaatccat ccagaagtgt atatccgccc gcagtcattt caccgagcct ctttaataac 2143741 ctggcttgat cctttaacaa ccagactttt ctaatctttt tcatgataaa cccaccggtc 2143801 atagttgttt gtcgttaaat agccgagcgc aattcctttt ctgataattt gacgaagcgt 2143861 ttgatattgg taatttgcat gatttccttt tgcctcctgg atacattgct gaagattttt 2143921 cccgtataga agctcataaa cgctagctct cctagtattt cgtgactgtc ggcaatacac 2143981 tgatgaacat ccgttttcac aaaacgggca agccaaatca accaagcgct gagccgctat 2144041 tgcaatgaca gtctgttcga tttcattcat attgataccg aattcaagca gtctgtaaat 2144101 tgcgcccttt gcgtctctcg tatgaaggct cgttagtacc agatgtcccg tcatcgctgc 2144161 ccgcaccgca atttcagctg tttccgcgtc tctgatctca cctaaaataa tcatatcggg 2144221 gtcatggcgc aaaattgctt tcagacctgc ggaataagtt acaccggctt tttcattcac 2144281 ctgaacctga agaacatctt cgtcccttgt ttcaacaggg tcctctaatg tgacaatatt 2144341 tcgattaaag tgtttttttg catattgaac gagagagtat aatgtggtag tcttccctga 2144401 accagtcggc ccggtaaaaa tgagcatgcc atgggaatgt tttaaaaacg agagtaatgt 2144461 ggctcctgtc ttcggaaata gcgacaattt atcaatcgaa gggatattgt attggggcat 2144521 cactctgatc acgaggcttt cttcattaat tgtgggcagc gttgacattc ttaaatgaac 2144581 atttccctct ttcaacttta acgtaagcga accgttttgc ggctttcgcc tttcacctat 2144641 atccattgct gaaagaaatt taaaatgtga aatcagtctt acgcactctt cttttttcat 2144701 gtcccttttt ttcagcaagg catgatcgac ccgaaaatga atgatagcgt cccgctccct 2144761 cggcacaatg tgaatatcag aagcctttgt tagatatgcc tcttcaatca agtttttgct 2144821 taccttttct attgaatcca atttgattcc ctctcctttc aacgcatatt gtagaaaaag 2144881 aagaaaaggt aatcaaacag ggaaaacgtg attttgtgag atgttatatg ctgaaaaacc 2144941 aattctttct ggcaagaaaa aagactttca actgaatgta cccctgtcat tataattttc 2145001 cctataaata aaaaagcaga catggtcacc atgcctgcta gattccattt tcattatgct 2145061 gttttcgctt attgaccagt atctttctca acggaaagat cgcctaatgc aacaataccg 2145121 gtcatttggt cattttcaag aatcgataaa ctgcggattt aatgctctgt cataagcccc 2145181 ttgacatcgt atccggtcac cctgatatgt ctggtgaaaa agcggggcac gctgcacaaa 2145241 atatgaaaca tcctatagag tccgcctttt tcgaggtttc tttttcttct tccgctcctg 2145301 cagcatatct cccgtccagc ctttttttct caaatagaga tagatcagaa ctgtagatgt 2145361 gacaatcaat aagagggaaa agagatatcc gtatttccaa ttcagttccg gcatcactga 2145421 aaagttcatc ccccataagg cacccagagc tgtaatcgga gtaaaaagcg tcgtgaaaat 2145481 ggtcagcgct tttacaattt cattccccct atgtgaggta atgacttcct ctgaatgcag 2145541 cagattgtta agctcccctt caaattcgct gatgtatgta aatcccctgt caatcttcag 2145601 ttgtgtccgc tgataatcct ttttcccttc attttgaggt aaaaaggttt ctttcaacgc 2145661 catttcaatt tttttagcgc ttaatatcaa atttttccaa atcatcagtt catggcgcag 2145721 gagatggacg cggtttaaaa tgcttttgct attgtcgtct ttaatttgcc atctgagctt 2145781 tctcagcttg acttcaaatt catcaacacc gattaaatac gcattcatta gttcgccgag 2145841 aagaattaaa aacccctcta tcgcattgtc cgctctttcc atttgccgaa caacttcttt 2145901 gcctttaatc tctctcaaaa ttgaaaagtc aaagttgatt gtaaaaaaat attgtctggt 2145961 gatataaaag tgaaaaacag tatggtcttt ttcttcacca agcccctgat cataaacaat 2146021 cgacccaaat actgcttcat tttccgtttc agttgtatct actcgcaaaa aattaacgtg 2146081 atggttattt tcaaaccact tttcacactg aggccagtga gaaaaatgga ttagatctct 2146141 tgccttactt ctttcttgag gccccatttg gtaccaaaac caatcctttc ccgtatgtgc 2146201 cttcatgtca agctcctcca aacttttgtt ctttattctt taattgccca ataaccgcgt 2146261 cactaaacca gtctgccgct tcaacacatg ttttatgagc attttcaggt ggtatggaat 2146321 gtagaaagac atcggaaaag ggaggtgcat gccttccttg gagaaggcag ttgttttgga 2146381 atttatcaat ttactagcag tcgctattct cattttgtta acaggatttt tcgttgccgt 2146441 agaattttca atcgtaaaag tgcggcgatc caaaattgat cagcttgtcg caaaaggaaa 2146501 gaaaggtgct aaagcggcaa agcatgtcat cactcacctt gatgaatatt tatcagcctg 2146561 tcagctgggc atcacagtcg cagctttagg actgggatgg cttggggaac cgactgtgca 2146621 aactctgctt cgaccgcttt ttcataaagc aggcttaaat gaatcgctta cccacctgct 2146681 ttcactcgtc atcgcatttt tagtggttac gtatttaaat gtcgttattg gggagctggc 2146741 gccaaagagt ttcgccattc aaaaagcaga aagcattacc ttgttgttcg ctaaaccgct 2146801 tatttggttt tataagatca tgtttccatt catttggctg ttgaaccact ctgcccgatt 2146861 gattacagga gtgtttgggc tgaagccggc atcagagcat gagctggctt atacagagga 2146921 agaacttcgg gtcctattgg ctgaaagcta taaaagcggc gagatcagaa aaagtgaatt 2146981 aaagtacatg aataatatct tcacctttga taaacgaatg gcaaaggaaa ttatggtgcc 2147041 gcgaaatgaa atggttagtt tgtcactaga tgaagactcc atttcaaatc ttcaggaaac 2147101 agtcaagcaa acaaaatata cacggtaccc ggttgtaaga gaggataaag ataacgtcat 2147161 tggcgtgatt aatatgaaag aagtgctgtt ttccatgctg acgaaagatt tttcaatcaa 2147221 gaagcatcaa attgaacctt tcgtacagcc cgttatccat gtaattgaga cgattcctat 2147281 ttataaacta ttgctgaaaa tgcaaaagga acgcactcat atggcgatcc tcatagatga 2147341 atatggcggg acgtccggtt tggtcactgt cgaggatatt atcgaagaaa ttgtaggaga 2147401 aatccgtgat gaatttgatg cggatgaagt gcctcatatc cgcgaacttg gaaaggatca 2147461 ttacttgtta aatgcaaaat tattaatcag cgatgttaac agcctgcttg gaaccgattt 2147521 atcagaggct gaagtagaca ccttgggcgg ctggtttttg acacaaaaca tagacgctga 2147581 gcctgaaagt gccatagaat atgatggcta ctcttttaag gtaaaagaca tcaacagcca 2147641 tcacatttta tttatagaag ttaaaaaagc tgaatagccc gtgaaaggct gttcagctgc 2147701 tatctttcaa gataaacatg gcaaaggcat caacactctt ttattttaaa ccctttattg 2147761 gccagggctt tagcaagact ttgctctgtt ttcacattcg aaaaatccag acccagcttc 2147821 acgacagttt gggcaatttc cggcctgatt cctgaaataa tagtctcaat gccgagcaat 2147881 ttggtgctgt caatcacttt aaaaatttga taggctacca tggtatcaac gataggaacg 2147941 cccgaaatat ctaaaaataa atacgagagc tttaacgctg agcactgctc cagcacagac 2148001 tccaaaatcg tcctcgctct gtgcgtatca atttcaccga caagcggaag aatcccaatt 2148061 ccatcagtaa tcggcataat cggcgcactc aattcattaa tcatttcttt ttgcgcgttt 2148121 aattgtatca tggtcacctg gtgatattct tccgtaaaca cttcgatgat ctcatcaatg 2148181 ttttgattca agatccggct ccactcataa aattcctgaa tgctgatgtc ttgagaagaa 2148241 gcttcgctga atttatgaat ccattcaaac atgatgtgcc tgaaagtgtt aaactggccg 2148301 acactttgtg taaccgtcac ttcatgaacg gcacggtctc tggcgcattg aagagaccac 2148361 cggttgagct catcctctac gtcttctttt ctaagggatt ttgctacgat ggtcaccaat 2148421 aattcatgct ggtcttttaa cttttgttct agtttttgct gatctttcgc tgaatacagc 2148481 cagctgccgt ttgacgtaca aacttccagc cattgttgcg taatatcttt tttgtgctct 2148541 gttaagtgct gatcaagagc tatcatctta atgagttacc tcctgttttt gaaaaatgta 2148601 cgctatatat gtataacgcg tctgccttta cacatactat gtttagattc aatgggctat 2148661 agccaagcgg taaggcaatg gactttgact ccgtgatcgt tggttcgaat ccagctagcc 2148721 cagtttctga acaggtgaaa aaccgaagat aagctgattc gtataaatca gcggatcttc 2148781 ggtttttcat catgcagatt gatgaaccgt tttcttcttc gataacttca acagttctcc 2148841 cgggttataa ccaatcacca gctttttgtt gtctactaga atcgggcgtc gcaaaagctt 2148901 cggcttctcg attaaaagtt ccagcacctc atttaccgtc atttcttcaa tgtttaaatt 2148961 taaatttttg aaagtctggc ttcttgtcgc caaaatttca tcaattcctt ctgtcgttaa 2149021 cgataaaatg tactttaatt cttctcttgt cggggtttct ctgaataagt gccgttcgtt 2149081 aaattcaatt tgatgtgctt taagccaatg ttttgttttt cggcatgacg tgcagcttgg 2149141 atatgagtaa aaagttaatt gttgttccat tcgttttttc ctcctcagtt aaccatctct 2149201 ttgtagaata actacccgga tcatttttca tttaaaccat ttacagaact tttttcggat 2149261 tattttttaa aaaacattca tacaatagaa aacacaatca aagggacaaa ttccatttgt 2149321 atattaataa tgaaaatgtt tacatttcta ggtgtgatct attataataa cagtcagagg 2149381 gactctcggg aggggataaa aatgaatcgc atgttccggg tgttaggatt ttggacggga 2149441 atttttgcag tcatgtttta tttaggtgat atgaaagatg cttccctttt attttttgga 2149501 cagacgatct tatttgtgtt tctatcgtat ttgaacttaa ccgaacgcat gtatatttat 2149561 atttttggcg cttatttaac aattttcttc gccggcttta catattactc aatttttatt 2149621 atggtgcccg gcggcggagg ccattaaatg cagaaagaga caaaccttat cggtttgtct 2149681 ctttttttac aatgaaaacc catttaaaaa cggattttga tcctgctcag tcagtacgtc 2149741 tgtttcaggt ccatggccgc ttaacaccag cgtgtgttcc ggaagcgtaa gcagtttttc 2149801 atgaatggac gtcagcagcg tctcttgatt gccgcctatt aaatccgtac gtcctatacc 2149861 gccttggaac aagacatctc cggaaatgac caagtctgca tctttcacgt agtaagacac 2149921 actgcctggt gaatgtcccg gcgtaaataa tgtttccaaa tgaaacggcc cgatattcaa 2149981 ctcaccgtcg ccttcaatta gatgatctgc aggcttagct gtgacttcta tccctcgcag 2150041 catgccggag ccgtttaaag aagcgtccgc aagccaattt ttttcatttt gatgcaggta 2150101 aacagggata tcccattttt ctctcacttc atcaagcgcc ccaatatggt caaaatgggc 2150161 atgtgtaagc aaaatggcta aaggcgtcag ccctttttct tttatgtatt gattgatttt 2150221 atgtccctcg ccgcccggat caaaaatcag acattgatca tcactgatga gaaaatatgc 2150281 gttcgcttga atcggcccta ctggcattcg tctccatttc actattatca cctctttctt 2150341 ttttatgctc ttattatgag ggtttttgaa aaaagattca aacaatcgca atgaaaacgc 2150401 tatcgacaaa cctataaaaa acaggtagaa taaaactgga aagaattgca ggtttttcaa 2150461 tgtaaagggg gctgtgttat gttacttgtc gtgattttcg gccttgtcgc tcttttcgct 2150521 ttatggggag tcttgcgttc tgttagaaat aaaaatatac tcgggttttt attagccggt 2150581 gccaccttat ttgtctttgg atggtttacc gtgatgaccg taataaacag cgggtatcca 2150641 accgcacatt aaaacctgta tccgatcgga tacaggttta tttttatggc tgtaaatgtt 2150701 tattgacact ttctattttg ctctcaagcg tcgttttttt gtcacgcctg tcatcgatac 2150761 ggatattcgt tgccactctg tgcaatcctt tttgaaatgg cgcttcgtga attgcctgaa 2150821 taactgcaaa aaggtcactg agttctccct cgatcagcgt attcatcggt gtcagctgat 2150881 atttgatttt cccttctgct tgatatcctt ctaatatctt ttgcacatcg gctacgtaag 2150941 cactgacact gggtgtttcc gtaccgattg ggataatggt tacatctgcg atagccatcg 2151001 ttattccatc tccttttgat caatgatgag ttgcttcgtt tcatgtgatt tcaataaaat 2151061 aatttgctca aaatgaaagc cgtataacgc atatttcccg ttcggagata tttgaatcgg 2151121 ctccatttcc cgcagagaca caagatcttt tgtctctccc gatgctacat tgattgctgc 2151181 gagcttatat gcatcgccgc tttgtttgaa tgtataaaac aggcctcctg cttcatcata 2151241 gtcatactcc attggagcca aacttgtata tttcgcttgg agcggccatt tcgctgtaac 2151301 aggtgatgtt gattgcggcg ttttaaactg atacgtccct tttcctccgg aagctgattt 2151361 gacagtaaaa ctcatttgat ggaaagaatc gaagaataga acgttatcct caagcttctg 2151421 ttccgtctta gaagctgtat cgaacgtata taaaggccct gttttatcgt ctctaccctc 2151481 ttttacataa tcaaatgtat ttttggatgt ccaatgaatg aacggaacct gtactgggct 2151541 taagaaagat tcgtcttttt tagcattcac ctgatatgta tggaaatccc agttttcatt 2151601 gaattccgtc accatcattt gataaggatc atactgattc caagcagctt caagctcata 2151661 cgtttcgtaa tctttttcgt aaagcgtctc tccttctgca ttaagcaaaa ccactgccgt 2151721 cttttggcta tgtgtgattt gcagcagaat catctgctcc ctcgcattga tttgaacatc 2151781 aacgatttga ccatccgttt gatagagctt tttcgctttg cctgtaaaga tgcggtacgc 2151841 aaaaagctct gttttcgtcg gattagacgc agtatataat attgtgctgt tattcagcca 2151901 gccttccgcc ccatccgctt tttccgcgga aagcggtatg atgtcttttt tctcatcttt 2151961 tgccgccgat gcctgttttt gctgctgatg agatggttcg catgccgata aactaaacag 2152021 caataccgcc agcagaataa aacaaactga tctcatcagc attcccctcc gatcatcttt 2152081 attctctcat atttgcttcg gcagaaaaaa gaaaaagttt cagttactca tgaaaaaata 2152141 acgccctcca caagataccg cttgtggcgt tatatatgtg tgaaaactgc tgaaacggca 2152201 aaggattttg gccttttcca agttccaccg tatacccttc cttaaaataa tggtgaataa 2152261 accaatcacg aaatccagca tagctgtcta tatcccttac tcccttataa atgttcccgc 2152321 ttaactcctc aaactccttt atgacggcag cagattcctc aggctcaagg cctttatagc 2152381 cccaataaat ttcttctcct tgagtatgaa gagccagcag tctgtcaggc ggattctccg 2152441 tgatcagccg gtacatcgca atagattccg gctccgtaag cggagagatt cccggaaaat 2152501 cgcggtagct gggtgctgtc ggttttcggt atttttcaat ttcccataat gatggaaatt 2152561 gtttatttaa atcaaccccg tttatattcg ccttccattc attaaaattt ggacgatgtt 2152621 catttagcct ttcgagttca tctcttctgg ctcccatgac ttctgatccg tttaaaacaa 2152681 gatcaacgcc atccggattg acaagaggaa cgagggataa ggatgtgctg ttaaacagct 2152741 ttatgggaga aaagccaaag aaaggcgaat tgcagcataa tgacatacag tattccttaa 2152801 accattttag caggacagac gttgtaatcc actcattcgc atgaaatgac gcgttcatat 2152861 ggaccttttt tacggcatgc tccccaccag ccttcagctc ccagataggc ctgccgagta 2152921 cagaacggcc aatttcccgg catgagacaa acggaaaaac atcaataatc ttctttattt 2152981 ccttttcaac agctgaatca tcatagattt tctcttgctc aatccagcta tctgaaagtt 2153041 tcagctgccg aggctgtaaa aagcgcttta tgtcctgaat ggtttgaagc tctttgccgc 2153101 tatgctcctc tatcacataa ccagggcaat acaattgatg tttttgtgcg gagcgatttg 2153161 cacttttaag caattcctcg tctatcttca gttctttcgc cacattggcc aaattgttct 2153221 tgatctcagg tttcaccgta ataaacgcca tcatcatccc ccttttttgt tactatatga 2153281 cagcgtattt aaaaaaagaa agcctcccgc tcacttcgat gcgggagaca ttgtgattat 2153341 gatgcctgat caagcatttg tttttctttc cgctttgacg aattgtccag ccttttctgg 2153401 tcataaaatc gcaacaaatc cccataaatg atttcatcag aaagtgatag ctcctgtttt 2153461 gctttatcag caaatgcttc acattgtttt gtctcttcta acggttttcc cgtctctttg 2153521 tcataacacg caccgtctgt ataaacaacc tgatctgtga taaagctccc gtcccggagc 2153581 accgtgaagt ccagtttttc gtctgaaagc agatcgttgc cgaattgaat ttgatctttc 2153641 gtatcaatcc ctaaaagatt catcagcgtc ggcctgatat caatctgccc gcctactgtt 2153701 tcaatggttt gcggcttttt atcagtaata cccggaatat gaatgaccag cggcactttt 2153761 tggagctgta cctcttcaaa tggggttatt tcttttccta aaaactgccc catcgcttca 2153821 ttatggtttt ctgatatacc ataatggtca ccatataata caataacaga gttgtcgtat 2153881 aacccgtctt ccttcagctt ttcgataaac cgtttcagcg cctcatcctg ataacgcact 2153941 gtcggaaaat atttatttag cgtctggctg tttgaatcat attcatcaat caattgatcc 2154001 tcttcatcaa gatcaaacgg gaagtggttc gtcagtgtaa tcagcctcga gtaaaacggc 2154061 tgaggcagat ttttcatcag ctctgaggac tgctcaaaaa attctttatc cttaagtccc 2154121 cagccgactg aattttcgtc agttacatca tacgagttaa tatcaaaaaa cgaatcatat 2154181 ccaaatgagt cgtacattaa atcacgattc caaaagctct tattattagc gtggagcacc 2154241 gctgaatagt atccgctgtt tttcaaaatt tcaggagcgg ccatatattg attgcccgca 2154301 ttcgtaaaaa atacggcacc tcgtccaagc ggatacagtg aattgtccac gataaattca 2154361 gaatccgagg ttttcccctg gcctgtttgg tggtaaacat tattaaagtt gtagctctgt 2154421 tttataaagt cattcagaaa aggcgtgatt tcttctccat tcaatttttc attaatcacg 2154481 aagctttgcg tcgactctaa ggatacgaga atgacgttcc ttccttttgc agcgccgaat 2154541 aagcgtttgt tggcatcctt cgcattagcg gttacgtagt tttcaatctc cgtcaggctg 2154601 ttgctgtctg ccaacgctct ctgtgcggat tgctttgact gaagaacgcc atcgtaaata 2154661 tgaaaattaa acaggctaat gtttttaaca agcatttctc tgtcaaatga gcgtgtcaat 2154721 agctgaggtc tttccgcctc agacaagccc aggttgaaga aataaacaga agcaacgaac 2154781 aaaaaataag ccgcccgttc atttttcgtt gagggaatgt ccgattgaaa agctttttgc 2154841 cggatgtgaa gccatattaa aaccgcaata tctacagcta ataggaggtc tgtcggctca 2154901 agaagtgttc cgatgctgct tccgagatca cccatattgc tcgtttgaaa aagaacaggg 2154961 attgttaaga aatcattgta aaaacggtaa aaaaccatat ttgccagcaa tacaaacgtg 2155021 acaagacagc tcatcgcgat aatgtagcga tttctgtttt tgccttttaa aaacaggctg 2155081 aggccaaaaa taagcaacaa aaaactcaat gggttgataa acagaataaa ttcctgtgtt 2155141 agattgtcga ttttaatatg aaaactggtt ttgtaaacag catacgtttt cagccacatc 2155201 aataaaatgg caatcagcat aaatgaaatc ttcgaaaaaa acgtttttcg catttcaacc 2155261 tcctatgcag cacgctcaaa aaaatcagtc tattcccaac attctcatta acacatcaaa 2155321 ttaaatctta acctgagcac aacaaaaaat caatttcatt tacacaattt taacaatttt 2155381 gatgtttcag ccattcattt ttagcgatcc aagcgcctcc gataacgccg gcatcatttc 2155441 caagtgctgc gattgaaata tcagcagctt gggctgcccg cggaaacgcg catttgcgga 2155501 atgttttctc gacttttgat ctcagcagtt ctccggctct cgatacgccg ccgccaagaa 2155561 cgattttgga tggattaagc gagcttgcca aatttccgag caccaaacca agatgcttgg 2155621 ctacataatc aaccacctca agggcaattt catcattttc acccgccgct tcaaacacat 2155681 ctcgcgctga caattgttcg gttgctttta aacgtgtcgt ctttttagca tttgctattt 2155741 tttcttttgc aattcttaca attccggttg ctgacgcaat tgtttcgata cagcccgttt 2155801 tgccgcagtt gcagggcgct ccgccttcag ggatgctgca aatatggccg atttctccgc 2155861 cggcgccatt tataccatgt acaatttcac catttgcaat gatgccgccg ccaactcctg 2155921 tgccaagcgt cacgagaatg acgtcttttg cgccatcacc cgctcccttc cacatttccc 2155981 cgagcgcagc aatattcgcg tcattttcta taacagctgg gatgccggtt tctgtctcca 2156041 gatggttttt caaagcataa tttttccacc ctagatttac tgtttcataa accactcctg 2156101 ccgccatatc tacagggcct ggtgcaccca ttccgatgta tttgatgatg tgcttcggtt 2156161 tttgcagctc atccagcttg ctgtcgattg tttttgcaat tgtgacagta atcgtgtcgc 2156221 cggttttatc tgtcggaact tcccacttat gctgaatttc gccatattga ttaataaaag 2156281 cgagtttaat cgtcgttcct cccaggtcaa tgcccgcaaa ccatatctcg tccattttta 2156341 tcaccttagc ctttataaaa atctcttccg ttttttgttt gttccaattc ttttcgaagg 2156401 acagctgccg ctctggccca ctgctccttt tcaatcatgt ggttcatgta taattccttt 2156461 aattcatcca gcataaactc aatttcaagc tctctgtctc caaaataaac aatgtggcca 2156521 aacgttttta acagctgctg cacatcataa aatgtattca ttttcctcac catttcttga 2156581 acttaactat cataagcgta ttcataagga agcggtcagt caagaagaaa acgctgacaa 2156641 aaaagccagc ttcctttcca tattccacct ctatgattct ttattgtttt caatttgccg 2156701 ctgcagctcc ttgtagcgct gctccttcgg cttcagtttc acagccgtct ggatggcctt 2156761 ttctgcttgt gcaagctcat ttttttccgc atacaataac gctaaattgt aataggaagc 2156821 atggtcttta ggttcttttt tcactgctcg ttccaaaagg gaaaccgcct gatcatattc 2156881 gccgatttga atatcagaaa cagcaagaat tttcaaaaga tcggcagagg catctttttg 2156941 cgctgcttct ccgttcagca attctgttac ttcttcatac tttccttcct gatacagctc 2157001 gcttgcctgc tgaatcagcg ctgactcctg gtgtgaaggc gaatgcaatc cgtaatataa 2157061 aaatccaaca gccaaagcaa tcagcaaaac cgctgacaac aatctttttc caaaggctcc 2157121 ggctttaggc aaccccagtg ctgctgcagc gaaaaagccg ccaatcaagc cgccgatatg 2157181 tcctgaatta tcaatattcg aaaccgcaaa accaaagccc agattgatga taataatgac 2157241 aataatattg gttcctatag ttcttaaaaa catttttcga ttagacaaag caacatacag 2157301 taatgcacct aagcatccga atatggctcc tgatgcccct gccgaaggat acgggctgaa 2157361 cacaaaactc gcaatcgaac ccgtaatgcc agcagccaga taaatcagca aaaatctccc 2157421 cgatccatac atccgctcaa ccgctgtacc aaccgaccat aaagccagcg tattaaaagc 2157481 taaatgcgct atgccgatgt gaagcacgat cggtgtcaga agccgccacc attctccttg 2157541 tgcaatcagg ctgttttctt ttgctccaaa agccaccagt gtctccgtat tagtgctgcc 2157601 tccgtttatt tcgagcaaga aaaacatcag gatctgaagc gcaataaata aatatgtaaa 2157661 agtcggtttt ccgttttgaa aaaccgccgc ttcagttttt ctctgttctt cttgtttcag 2157721 cactagcgaa aggaagcgtt ctcgcgccat ttgcgcgttt tcaaacgaag cgtgttcctc 2157781 tgaacaatct tctgtacgaa atgatggaaa aaccgcttga agatcatctc gaagcatcgt 2157841 tcctctaacg atcgccggct caactgacac agttcccttc tcaaaagttt tttttgcaat 2157901 ctcttcccag tcatcaactg gggcttccgt tgaaaaaaac acgttcagca gcttcatcct 2157961 tcgtctgccc aattgatgtc tgactcgttc tactcgttcg gcctgctctt cgatgtctct 2158021 aaccatttct tgacggaaat caagatcgtg cttataaaga cgaactagat catgagagga 2158081 cttgtccggc gcttccagcc atatttcatc tgactcaccg gcttgtatga cgccataccc 2158141 gctattcacc aggtgcgccg caattttcca atatgtatac tccagcaaaa acatgtttac 2158201 cgctccaata gttttttttc attataacag ctggcgctcc gaaacgccta ctgaaagcaa 2158261 aaaatcccgt ttttcacggg attttagaaa gcttgctgta taaacttatt gcggataaat 2158321 ggaattctta aaaacaaatg gataaaagac cgcctgattc ctggctggct gagtacagta 2158381 ttcataagac ggtagcgatt ttgataaaac atgacggcag aaaccgcgaa aatggcatat 2158441 atcaaaagtt ttttcatgat atccctcctg ccaatagggt ttgttattct accttattta 2158501 ttctcgaata agggacagga aagttatgaa aaacaagaaa taatccgatc ctctgttatc 2158561 agcttatgta ccgggatgtc atgcggcaga cggggtacgt gcgcaaacaa ctggcactcc 2158621 aaaagcaaag agactgtctt cccttcatat tcacttaaat agcgatcata atagccgcct 2158681 ccaaagccga ccctaaaccc gttaacatca aaacaaacac ccggaacgat catcaagtca 2158741 atttgtgatg ggtttacttc ttttgttttt tcaattaccg gctcgagcag tccggcgtac 2158801 acggtttcga gctgatcatc agtctgatat gtgcgaaatt gcattttctt cgtgtccgga 2158861 tggcattttg ggatgcaaac ttgtttccct tcttcccaag cctgctcaat gacaggacgc 2158921 gtcggtatct ctaatcctct ggaaatagtg acggcaatgg tgccggcatt ttgccactcc 2158981 ggcagagaaa acaagtactt atacatacgt tccgtttttt gaagaatatc ttcatttgat 2159041 aaagcagaca gtgcctccag cgtctttttt cttaattgtg atttcatctc tcatccccct 2159101 cggaatagaa aaaaagccag aacctttttc aaagctctgg cttttttctt acacctcaaa 2159161 cagcaaagct gttattttgt ttcacggtgt aacgtagatt ttttatcacg tgggcaatat 2159221 tttttaaatt caacgcggtc tggattgttg cgtttgttct ttttagaaat atagttacgc 2159281 tcaccacatt cagtgcaagc caaagtaata ttaacgcgca ttattttccc tccaaactaa 2159341 aatcatttac ttattcagac ttatatataa taccactata atggacggaa tgctaggctg 2159401 tttttcaatg aattgctgaa ttattgaaga tacgctcata aagctgcaaa tatgatgaca 2159461 taatgagtcg ggggtggtgg agcttgaaca cttgttgtct gccagcttct tttatccggc 2159521 gggctttttc ccggtctttt aaaaaactgt ccagcagatc agcagcttcc tgtacgagcg 2159581 taaaatcagc gatgattgcc gttttgtcat gaaccgcata atcacaaaaa ccacctgact 2159641 gagaaacgac agtcagcaca ccttgttcca tgctttcttg cgcggcaagc ccaaacggtt 2159701 cataagaact agggaaaaca gccatttcac agtgagacag taacgttctg atatctttcc 2159761 tatttagaaa cggcagaaac atgacgcgat ccttcaggtt atatgccgca gccaatttct 2159821 catagcagga cagagacggc ccctccccag ccagcactag atagaggtca ggctgacgct 2159881 gcttcaagat ggcaaacacc tttaacagct gcgataatcc tttttccgga acaaaccttc 2159941 catatgaaaa gaggaatctt ctattcatgc ttctcgggat tttccccttc tcttcctcca 2160001 tagatgcagg gcttgggata acggttattt tcttatgtgc cgccttatca agagaccgct 2160061 tcataaatgt gcttaatacg atcaatgcat cagcggattc tataaggagc cgttcggtca 2160121 tgagcctgta tgggtgtggg gcttctcggc acaccttctt cctttcgctt tcaagaccgt 2160181 ggattgtcgc agcaagcgga aggccaagcc gttgtttcaa atactgggcg gcaggggcag 2160241 ttgtgtcatc atgggcatga atcagatcaa agcgtttatt gtgtgataac acatggcgaa 2160301 ccattgtaaa gttagcatca gctatgtaat cttcaaactt cgcatacgaa aacagctgcc 2160361 cgctcggagt aaaaaccgta atgttgatat gagggtttaa ataggaaatg aggcggttta 2160421 aatggacacc gagcccgctt ttcggctcat cgggatgttc gggtgaaagc atgagaatgt 2160481 tcaccgttct ttttcccctc tcccataaca ggtgtatgca gaaaattgcg cctcccacct 2160541 ggtgtgcgct tcttcaatct gaaaactgtt tatatgacga atcccatttt catcaagata 2160601 gatgtcgtct gtaccggcaa gcttgagaga gacattcatt gaattcacaa ttctgtattc 2160661 agcccgatat acagcatcac cagccgcctg tctaatcgtc cattctcctt tatcatacgt 2160721 tgtgcgtttt gtcctgacag cttcaatgtc ttttcttttg atgacaatgc gcaattcttt 2160781 tatcatatcc tgcgtttttt cgaaaaggac cgcttcagcc agccgcattg tttcttctga 2160841 gatttcccag cttacggtca aggtgtgagc gttttgaatg attatgtcga atgtgtccct 2160901 aaaaaaggaa agcttatgtc gtatattata gggaaatggg tgtttatcca tggactccta 2160961 acattctcct ttccaatcgt tcacttcgtg ttcctattaa accattacat gaagaagaag 2161021 cgaagaaaga tttctcgaca aaatctcgtt tttttcgcga attcctttag aaactattgg 2161081 ttttatggta taaaaaagaa ggataaaaaa agaatagaag gtgatgaaac gtggaaattg 2161141 ctattattgc gttgtttatc gtcagtatag cgctaattgc attctcatat tctcaaagag 2161201 acccgatgaa agatgtagaa caggagctcg aaacactgca gctttctgcg atgcaggaaa 2161261 tttacaagct caaaaagaaa atgacagtgc ttgaggaaga attactggaa acaaaccttg 2161321 tcattcgcaa atcaaagcag aacgacatca atcaaaaaat cgctaaacaa atactttcta 2161381 aatataataa cggtatgtca gctgaagcga ttgctaaagc tgaacatgta tcagtggaag 2161441 acgtgaatac gattatcaaa gataatgaga aggtgctcgt atgacaaaac ggggcattca 2161501 ggcatttgct ggcggcatca ttttagcgac agccgttctt gcagctgttt tttatctgac 2161561 tgacgaagac caggccgctg ctgtaaaaga taataaaaca gtaaccgaac aagacgtgaa 2161621 caattatctt gattctaaaa aattggtttc tgtcaaccgt gatgaatatc aaaaacttct 2161681 cgattcaaaa gagaaatcct taaacaatga cagcggctca gacacgaaat cagacaaagt 2161741 caaaacctac aagctcacca ttaaagacgg catgagcacg gcggatgtat ctgctattct 2161801 tgaaaaagag ggcattatct cttcggctca agactttaat gactatgtca ttgatgccgg 2161861 ctatcacaaa gaaattcgtg ccggcgagtt taaagtaaaa tcagacatga gtttcaaaaa 2161921 gatcgtaaaa acgttaacac gataaaaaaa caggctgact cagcctgttt ttttcatcca 2161981 aactttcctg aaatgtaatc gagcgttctt tggtccttcg ggttagagaa cattttattc 2162041 gtattgtcgc attcaacaag ctcgcccatg tagaaaaagg cggtttgatc agaaaccctt 2162101 gctgcctgct gcatgttatg cgtgacaatg acaattgtat atttatcttt cagctctaga 2162161 atgagttctt caatttttct cgttgagatt ggatctagtg cagatgtcgg ttcatccatc 2162221 agcaaaatat caggattggt cgcaagtgct ctggcgatgc aaagacgctg ctgctggccc 2162281 cctgacagcg aaagagcgga cgtatgcaat cgatccttca cctcatccca taacgccacg 2162341 tcttttaatg acttttccac aatttcctga agcttcttct tatttttggt gccgtggact 2162401 ctcggtccgt aagccacatt atcaaaaata gattgcggaa acggattccc tttttggaat 2162461 accatgccga tattttttcg caaatccacg atgtccactt tatcctttaa aatgttgctg 2162521 ccattatagt tcagctcacc tgcaagcttt acattcggcg tcatttgaat cattaaattc 2162581 aatgtcttga taaaggtcga tttcccgcat ccggatggtc cgataatcgc cgtaacctca 2162641 ttttcataaa tgctcaaatt gatatttttt aaagcatgat gctgcccata ccataagttc 2162701 attccattga cttgatatac ttcctgtttc attacagctt cggtagcaat actcattgcc 2162761 gccctcctat ccgaatttcc cgttaatata atcctctgtc ttttgctttt tcggactcgt 2162821 gaaaatctgt tcggtctgtc cgtattctac aagctcgccg tttaaaaaga atgccgtccg 2162881 gtcagaaacc cgcagagcct gctgcatatt gtgcgtgaca ataataattg agtattctct 2162941 tttcaatcct gtaattaatt cctctatttt tgcatttgaa atcggatcaa gcgctgaagc 2163001 tggttcatca agcagaagaa cagccggctt catcgcaagc gttctcgcga tgcataaacg 2163061 ctgctgctgg ccgccggata acgagagtgc ggatgaatgt aaacgatcct tcacctcatc 2163121 ccagagcgct gcttttgtta aactttcttc cacaatttca tctaaaacag ctttattccg 2163181 ctctccggca tatttcaatg catgtgtgat attcgcatag atcgatttcg gaaatggatt 2163241 tggtttttgg aaaaccattc cgatttctct tctcaagctg acaacgttaa tattgccgcc 2163301 caatatattt aatccctcat aaaggatttc accttccgct cttgcagatg gaattaaatc 2163361 gttcattcgg ttaatatttc tcaaaaaagt agattttccg catcccgacg gcccaattaa 2163421 agcagtcacc gcattttttt caatatccat gtttacatga tgaacggctt gtttatttcc 2163481 gtaataaatg gacagatctt tgacctcaag cacgtggttc tgcttcggaa caataacagc 2163541 tcgctcaggt ttttctttta ccatttgttc agacatgttt ttcgcctctt tccgttctaa 2163601 tttgccgtaa gctttttgta gatcatcgtg ccaagccatc tcgccgcgag attaaacaca 2163661 agaacagaaa tcaccagcac ggcagaacca ccgttggcaa tcgcttcagc atccggaatc 2163721 attccttgtg tattgacgtt ccaaatgtgg accgcaagtg tttcagcggg cctgaaaata 2163781 ttaagcggtg atgtttccga aaacgggttc cactccgtaa aattaagacg cggtgttgtc 2163841 aggcctgccg taaataataa tgcggccgct tccccgaaca cccttcctga cgctaaaatt 2163901 gctcctgtga tgatagaagg aatcgcactt ggaattaaaa ctgtttttac ggtatgccag 2163961 cgtgatacac ctaaagcgag agaggcttcc ttcagatctt tagggactga acggatcgcg 2164021 tcttctgtca cacgcaccat gacaggaagg ttaaaaacag ttaacgcaag cgctccgcct 2164081 atgatcgtat aaccccagcc tgttaagttg acaaacatca ataatccaaa catcccaatg 2164141 acaatagacg gaagagatga aagcacctct atacatgttc taatgaagtc agttactttg 2164201 ttattaggcg cgtattcagc catgaagact ccgccgccca caccgagcgg gattgtaatc 2164261 agcattgtaa taaacaaaat ataaaaggag ttaaacagct gatctcgtat gcctcctcca 2164321 gctgcaatgg cgctcgactt tgttgtaata aattgaaaac tgagctgaga aacaccgttt 2164381 ataataatat aggaaaacaa acctactaaa atggcagcga taatggctgc acacaaacca 2164441 aacattccgg tcgccagttt atctgttatt ttgcggttca ttacactttc ctcctagatg 2164501 acaagtagcg aataagcagg atgaacaaga atgacatcac cagaagcaca agccccattg 2164561 accacagcgt attgttttca acacttccgt atgtggtgtg gcccatattc agcgtgatga 2164621 tcgttgtcag cgttcccgca gtgtcaaacg ggctttccgg caatactctt gtatttccaa 2164681 tgaccatctg aacagccaaa gcttcaccga acgcccgagc catgcctaac acaacagctg 2164741 tcatcaatgt tggaaaagct gcaggcacaa gtacttttct gatcgtctgc catcttgtgg 2164801 caccaagcgc gtaagaaccc tctcgtaaac tcttcggaag agaagccatt gcatcagcag 2164861 aaatcgatgt gatcgtcggc agaatcatga cggaaaggac aatcgttccc gccaataaac 2164921 tgtgccctgt tccgctcgat ttgaactggg cgataaacgg caccaatact gtaagaccta 2164981 tgaatccata aacaacagat ggaataccga ctaaaagctc aatcaccggc tgcagcactt 2165041 tctttcccca attcggggca atctctgtca taaaaatcgc acctgcaatg ccaagcggcg 2165101 cagcgattag agcagaaaga atcgttactg caaatgagcc aaaaataaat ggcagcactc 2165161 cgtatttcgg atcactatct gtaggattcc aatttaagct cgttaagaat tcaattgggc 2165221 ttacaccatt tacaagaaaa gattgcagcc ccttaacgcc gaggaaaatg gtaatcgcaa 2165281 cagatgccgc aatcataatc agtgcacaag ctgtgactat cattcttccc cgaacttcat 2165341 ccaattgccg attttgccta gagctgatta agcgctcgct cacagacata ttttctctat 2165401 tgtttatcat tgttttacac tcctatgaat gtgttaagag gagaaacggt tgtccccgca 2165461 ctcctctttt tattaagatc agctttgctt cccgttggca tcacgtgtca ctttcatatc 2165521 agtaaccgga atgtagcctt ggtcagtaac aatgcttttt tgaatgtctt cactctttag 2165581 ataatcaaga aattctttag ctaaacctgt cgcttcacct tttgtataag aatgttgata 2165641 agcccagatc ggatactcgc cagttgctac atttttcgct tcaggtttaa caccgtcaat 2165701 agatagagca gttactttgt catctgttaa atatgagaat gcaagatatc caatcgctcc 2165761 cggagtatca gcaatgatct ttttcaccgt gttggaggaa tcttcagtaa tgccttctgc 2165821 aggctccgct ccgtcaagcg catatttcac aaatgtagca cgtgtgccgg aagaatcagg 2165881 gcggtttaca agtgtaatct tttggtcttt gccgccgagc tctttccagt ttttgatttt 2165941 gccagtgaag atttttttca attcatcttt tgaaatatcc tttacaccag catcagggtt 2166001 tacagctgct gccataccaa ctacagcgac ttgatgatcg acaagcgctt ttgcatcgat 2166061 gccttctttt tcttcagcaa aaacgtctga attcccgatc tgaacagctc cttcagagac 2166121 ttgagaaagc cctgttccag aaccgccagc ttgtacctgt atatcagcat cagggttttc 2166181 ttccataaat ttttccgcgg ctgcaagtac tagtggctgc attgccgatg aaccagaaat 2166241 ggttaaagaa cctgatgcct tttcttctcc ttttgcagaa tcgctattcg attttttact 2166301 ttctcctgca tttccgcatg cagctgcaat catcataaaa gcagccatca gaagcataag 2166361 caccaatttg ttttttttca tttcctgaat tccccctgcg tataatgtgt aatttgtcct 2166421 acacgtatag agtaaaggtt ctatgtaaaa agggtttgaa ccgaatgtta aggttttgta 2166481 aatcagtgcg tttttttgta taaaaaaaac gcccacatca tgtgagcgtt tttttttagt 2166541 tatcagaaga cgttgtgttt tctgcatttt cttcaatttt gtctttattc ttttgctgag 2166601 taccttcttt gtcctgcttc gatttcagct caaaatattt atccattact tccctgccga 2166661 tttcgtttgt aattgagtat ctttgattgt aatcaatgta agtccaagga actacgacag 2166721 aaatagcaat ctcaggattg tcagctggtg cataagccac aagcgtcgta ttataagtgt 2166781 ctgttcctgt ttttgattta tccggtccgt cgtaaaatga ttgggctgtt cctgtttttg 2166841 cagctggttt atacgatgct gaagccagtt gacctgcagc tgtcccttta gtggcaaccc 2166901 gtctaaaacc ggcttggacc tcttcaatat agctactctt catatcgact ttattcaata 2166961 cttcaggctg aacagaatca acgactgcgc cgatcccttt tttcgcattt gaatctctga 2167021 cttcctttac aagctgaggc ttcatgcggt agccaccatt tgctatggtg gagacatatt 2167081 gagccaattc cagcggtgta taagtatcat actgtccaat ggcgaaatca agcaagaaac 2167141 cagataatct gcttgtacct ttatatcccg tcatttcatt tggtagatca attcctgttt 2167201 ttactcctaa tccaaattga ctgaaataat ttctgaaggt atcaaatgca gaagtatcca 2167261 aaggcaatgc ttggtgaggt ttatattcac ctttaccaac tgcaattgct gttttaaaca 2167321 taaaaacgtt tgatgacttc tctaatgcag tttgaatacc aaccggccct aagttttgcc 2167381 aagatttttt ccctctttta tcctggccga tatacaatgg ttcatcctta aatacagtat 2167441 tcaaattaat cgctccagtt tgaagaccgg tcaaaacggt tgcacctttt acagctgatc 2167501 ccatagcgta ggatgaagtc atggctccta atgcataatc atcaaactta taggctccat 2167561 tttctcgttt aatctgcttc cctgccattg tcagcacttc gccgtttcta gggtccatca 2167621 tgacaacgaa tgcacgatcc aacaattcgg tactaggtct tgctttagca gctttaagtt 2167681 ttttctcaat aattttttcc actgattttt gcaaatcaat atcaattgtt agtacaagat 2167741 ctttcccggc tttgccttca gataccgttt ttgttcccgt gacattgcct tttgaatctg 2167801 tgatattttc gacttttgct ttttggccct gcagaaggct ttcatattgg tattccagat 2167861 agctttttcc gaccctgtca tttcggctgt agccaagcga cagataatgg tcgagcaagt 2167921 tggacggcaa tccttcatta gagctggaaa cacttccgag cactgagcga agaaggtttt 2167981 tataaggata ttcacgttcc caatcggacg tgacatcaac acctggcagt tcgtctaaat 2168041 gttcacttac cactgccatt tccttcgctg atacatcttc gtttttgata tattgagggg 2168101 tcaatgcata gcccgaatcc atctgtcttt tgatagcaag gatctgcata tctttatccg 2168161 tcaattcatt cagctgctta tcagtaatcc gttttagctg aagctggtat aaatcgtcat 2168221 cggatatttt tttgtcttca acctgctgtc tttctttaga gctaatgagc tttttcgctt 2168281 ctttcggtct agtcaaaatc caataatctt ttttatcccg ttctgttact ttttttgtat 2168341 cgactttgat catgtcagac agcttttttg cgatctttaa gcgctgttct tgcgtggtcg 2168401 atttagatct cgtgtatgtg attgcattta aagccttatt tgtcacaatg gcattaaagt 2168461 ttcgatcata aattttcccg cgtggtaccg ctgagctgac ttcactttgt tcctgcttat 2168521 tcgcttggtt tttgtaatca tcaccttgca cgatctgctt gatgcccagt tccacaataa 2168581 tccaggtaaa tataacaaag gcagctaaaa ataaaatatt cagccggatc ggaagcgact 2168641 tctttttctc tttatgattt tgcttttttg gtttatttct cctcataaca tcaccttttc 2168701 tatttacaga aagaaaagac actcaagtaa gagtgccagt tttcatttta aaggtttttt 2168761 cgactttttt ctacagataa cccctttttg gcaaaaaaat tatctctcgc cttttaaaag 2168821 ggtcggttct gttacccgtt tttggccgtc ttcttccatg gtttcatttt ccccttcttt 2168881 ctccttaaaa cgaatatcct tgacaaagta ataaatcaaa ggatgtccta tacccaatat 2168941 cgcaagtgac aaaggaattc ccacatcctc tttcagaagg gccacaatca ggagaaagca 2169001 caaaatggaa acaattctgc cggcgttcaa gaacatttct ctaagcacga tatattcaat 2169061 tcttgctttt ctggcatgcc tcgcgcgccc tatcacatca tatgtaagtg atacatatgg 2169121 cacaagcaac agaggatagc cgatggcaat aaaaacgccg tacgttaata atgtcgaaaa 2169181 gctcatatgg aacagaatca aaaacagcgc gccatacaaa ataagtccgc ccagcaaaat 2169241 cgattttttt ctcgcctttt tcttaatcag cctggatgca aagtagtagg caaagaagga 2169301 aacagctgaa ttgacaagac cgaatgtacc gagagcaagc tcgctgtttg tctcaataaa 2169361 tacaaacaca ctgattaaaa agacaaaaat cccttctctc aaaccctgaa aaaaatgcgc 2169421 attcgtgatt ctccgccaat tcatattgct atggcgctct ccaaatactt tgctcagcat 2169481 aaaacggccc tttgattctc tccgttttaa gaaaaagctc atcacgacag ccagggcaaa 2169541 taaactgagg gagagactga aaatcactgt ataacccgta ttattttcaa gccttgagat 2169601 cacgaatccg gctacaatcg ggccgatcat tcctgcagag gaagacagaa tgcccataaa 2169661 cccgttgaaa aagtctcgtg tatccggctc tgttatttca aaggtcagca cgttaaacgc 2169721 tagccaataa aagccatagc caactccgag caccgcgccg attagcacga ggcggctggc 2169781 cgccgtttct ccggctaaaa gcacacttaa ataaaaggca gctaaaaaaa tgacgccgaa 2169841 ccttaaaatg aataccctgt ctattttttt ggctaaccgt ccagccaaat aaaaggttat 2169901 cggctgcatt gtcacaatgg ataaattata tatcgccaaa tcaataaatt tccctgactg 2169961 cttccaaaga tacacattaa caaatgtatt ggacagtgca attcccagcg agtaaagccc 2170021 gccaatggtc agcagaaaga gtaagccttt gtttacgtct acatcgccta tcactttttt 2170081 tagtttgctc attactgact cccctttact atcccttagt ctgtctcact caaaccgaga 2170141 tatgtaaaaa gaagacataa aaaaacaagg tcccataatg aggaccttgt ttgtgccatt 2170201 attttgcttc gctgtataga cgagccactt cgtcccagtt tacaacattc cagaaagctg 2170261 aaatgtaatc aggacggcgg ttttgatagt taaggtagta agcatgctcc caaacgtcaa 2170321 gacctaagat aggcgttttg ccttctgaaa gcggagaatc ttggtttggc gtgcttgtga 2170381 tttcaagttt accgttgttc acaacaagcc atgcccagcc agaaccgaag cgtccagctg 2170441 ctgctgctgc gaattgctct ttgaatttgt caaagcttcc aaatacactg ttaatctctt 2170501 cagcaagcgc gccagtcggt tcgcctccgc cgtttggaga taaaagtgtc cagaataatt 2170561 tgtggttcgc gtgtccgccg ccgttgttgc ggactgcagt gcggatgttt tcaggaacag 2170621 aatcaagatc tgcaacaagc tcttcaactg atttgttggc aagagcagtg tttccttcaa 2170681 ccgctttgtt taaatttgtc acgtatgtgt tgtggtgttt cgtatggtga atagtcatag 2170741 tttccttgtc gatatgcggt tctaaagcat cgtacgcata aggtaattct ggaagttcgt 2170801 aagccatgat aattcctcct tagtatatat gtactgaaat gccgcttcac agcgagcctt 2170861 tcttcattca atgtaacaaa agaatgcttt gtaatcaatg aaaaagctca cgatttggct 2170921 catttcagcg gacatatttc actttaaccg ataatctgcc ccattaaacc tgccgccagc 2170981 atttcttata ggaccgtcca taaaaagtaa ccgatcatca aaagctgtat gatgcccttt 2171041 gcaataaccc ctgttaaaaa accaatgagt gagccgaggc caattttaaa cgctgacttt 2171101 aagtccttct gatggacgat aagttctgcg caaacagccc cgataaacgg ccccaatatg 2171161 atccctgcaa ccggaatgac aaaaggcccg attaataaac cgatcgtgct tccccatatg 2171221 gcagctttgc ttcctccgaa cctttttact ccaagcagat tcgacacgta atctgctgcg 2171281 aataatactg cggcaaaaac tgcctcaaca agccagaaca tataagaata cggactgaat 2171341 gaaaataaaa atccgtacaa tacaaatccg gcaacaataa atactacgct aggaataaca 2171401 ggatacacca gcccgataaa ggcaatgata aaaaccgctg caatcaacag ccaatacaac 2171461 atatccatag cttccatcct cccattttac tctgtcttct tcatgtcttc cttgtattca 2171521 cacgcatgca acgatacaat aagcaacata tattagttta gctaggaagt gaagatagtg 2171581 aatgtgtttc agcttttcat taaaagtaca tactctcccc gtgatattgc aaaaacaaga 2171641 tttcaaggaa tcggaaaagc gattctttat gtatttttgc tctctgtcct gtttgcaatc 2171701 cctaccgctt attatgtaag tacagggacc gtaaaatcaa tgaacggctt taaaactgtt 2171761 ttaaacaaag atttccctga tttcacaatt tcaaacggca aacttcaaac ggatgagaaa 2171821 aaagccacgg aatctcaggc aaatggtttc gttatcgtgt tcgatccgac agactcctat 2171881 ggcactgaac aaattgaagc aaagcaaaac gcaatcggca tccttcagaa caaatttgtt 2171941 ttggccattg acggacaagc ccaagaaatg tcttactcaa tgatgccgtc agagttacag 2172001 aaaaaagatg tcattgcagg tttaaaccaa aataaagcga tgattgtaac tgttctctca 2172061 gctcttattt ttctcgtaac agcagcggga aaatttattg aagtatcgtt tttagcgctt 2172121 atcgggttaa tcattaagaa ttcgcagaaa aaacatttat cctatcatca gctctggaag 2172181 ctttctgctt attccatcac actttcaact gtattcttta caatcatgcg ggcactagaa 2172241 gcaaccgtac caagtgaatt tttgctgaac tggtttgtca attttgtcat cctgtttctc 2172301 gttttaaaag agattccgtc caaaaaagta attaataaaa gttaaattat atttattttt 2172361 atcctttaag tagagagtgt gaaagcattt gcattaactt tttacttaag ggatatttaa 2172421 taaaatgtat agagcttaaa cagatacatt tataaaaaaa gctctacaat tactcaagaa 2172481 caagctctgg acaataatat cagaagtagt aagatgtaac atgaaagaag ttcttaacag 2172541 catttgacat atgtttttaa caaaataaga ataatgttaa attttaacta atagactagt 2172601 taaaatcata tggcaaaata ttttgcatcc tttcacaaca tatttacata agatagttgc 2172661 tatttaaaaa gccaggtacc aatagggcac ctagctttca gaattaaatc atcaacaagt 2172721 tagaattatc ttctttcctt ctattctcat tattgaactg ttatcttttt tgtgggttta 2172781 tgtatacaaa tgcagctccc ttagctttcc ccttatatac tgataaacct actgcccaag 2172841 gtgttcctgt cggttttggt aatttactga agtaaaactt tttggttgga gttctacttg 2172901 aaaagtaccc tgaatattgc gggccaatgt ccccaccctc aactatagat acaccaaagc 2172961 tcttataatt tagtttaccg cattttccat ttgtttcggc gtaagcatca atagatgttg 2173021 cactcttagt atatgtataa gcatctgtaa taactcttat tttacaacca gaaataccac 2173081 ttaccggttg ccaaccactg cttgcagcct ctgctttttc tttaggtgca actaccaaag 2173141 ttaacattag tagcaaaatt aaaaacacag aaaattttcc ttgcttcatt ttgtagatcc 2173201 tcctttaaac tattacataa ttatcctaac agatccattg ttcattgtaa ataatggaat 2173261 acgagtttta tattataaaa gcctcttttt gatctaattt tgcactattt tctattttct 2173321 atctgaagtt aatgtttagt cgaagaaatc ctgtcaaaaa agcgcctgta taaaaaccga 2173381 gcattcgcag tctcttttct tttgtcatga atcgaaatgg acaagcatac tatggtataa 2173441 aatttcgtat gcgggaggaa aagcgatgaa gcgtctcacc ttagtatgca gcattgtttt 2173501 tatacttttt attctttttt atgaccttaa aattggaacc atacccattc aggacctccc 2173561 tgtctatgaa gcatcagcaa aaacggctgt acaagaaccg gcttataaaa cggtgaaggt 2173621 aaagccgggt gatacggtta tgtcgatagt cggatcagca ggttctccgg atgacattgt 2173681 aaaggatttt gaagcactga atccaaatgt gaaagctaac gccattcaag ccggaacagc 2173741 gtataaattc ccggtctacc cttaatttaa cgttaatttc ttgtcagttc ggcgaagaca 2173801 ctgttacaat gtaatttgta aaataaattc acataaacca tactagaatt gttatatcta 2173861 gaagcggcaa ctacaattaa ggagcgattg caagtgagtg aaatcacaca tcgtacaaaa 2173921 acgcgtcccg tcaaagtggg acctttaaca ataggcggca acaatgaagt tgtcatccaa 2173981 agcatgacaa caacaaaaac acatgatgta gaagcaacgg ttgcggaaat taaccgtttg 2174041 gctgaagccg gatgccaaat cgttcgggta gcatgtccgg atgaacgggc ggcaaacgcc 2174101 attgcggata ttaaaaagcg catttccatt cctctcgttg ttgacataca tttcgattat 2174161 aaacttgcgt tgaaagccat tgaaggcggc gcagataaaa tccgaatcaa ccccggcaat 2174221 atcggccggc gcgaaaaagt tgaagcggtt gttaaagcgg ccaaagacaa aggcattccg 2174281 atcagaatcg gagtaaacgc cggttcattg gaaaaacgga ttttagaaaa atacggttat 2174341 ccgactgccg atggaatggt agaaagcgca cttcatcaca ttaaaattct tgaggatctt 2174401 gattttcacg atattattgt cagcatgaag gcctctgacg tgaaccttgc aatcgaggct 2174461 tatgaaaaag cagcgaaagc gtttgactac ccgcttcacc tcgggatcac cgagtcagga 2174521 acactgtttg ccggcacagt aaagagcgca gcaggactcg gcgccatttt aagcaaaggc 2174581 atcgggaaca ccatgcgcat ttcactaagc gcagaccctg tagaagaggt aaaagtagca 2174641 agggagcttc tgaaatcttt cggcttagcc tccaatgctg ccacgctcat ctcatgcccg 2174701 acttgcggcc gtattgagat tgatctaatc agcattgcca atgaagtgga agagtatatt 2174761 tctaagataa aagcgccgat taaagttgct gttctcggct gcgctgtaaa cggacctggt 2174821 gaagcgagag aagctgatat cggaatcgcc ggcgcacgcg gtgaagggct gctgttccgg 2174881 aaagggaaaa ttgtccgtaa ggttccagag gaaacgatgg tagaagaact caaaaaagaa 2174941 attgacattc ttgctgagga acactacgca aaacttgaag ctgaaaaagc aaaattaaaa 2175001 gaagaaacac aaaaagcttg acgggaaccc gtcaagcttt tttgtgttag aaaaatggaa 2175061 taataaatat tccaagcact aatgaaacga caccgatacc cattgcccag gctccaaggc 2175121 cttgagcacc tcttcttctt gcgatatagc cgacaataat accagcagct cccaataaaa 2175181 caggcagtac aaacaatgaa atgatggaca aggctaaagc gatgtaccct attccccgtc 2175241 cttcattgac attgccgccg ctgcgatcat tgtcttggtc attgctgcgg tcagcagcac 2175301 gataaggctc tgcgatttca gcagctgttt cctcaaaaaa accgtcattg tcgcgggtaa 2175361 tatttgtccc ttcagatcca tgatcaacat agtaactgtt gttatcacgc ttttcgtaat 2175421 cgtttgccac cttcaattcc cccttctgtt ttattaaagg agcttttata gtttgatcca 2175481 ttttgcctga ttcatgtttg ctaaactttt ctgttaatgt caattgttta tgttacactt 2175541 gaagggatga aactgaagga gtgtgggcat gttacgctta ggaatagata ttgacggcac 2175601 aatcacggct caggatacat tcgtccctta tttgaaccgt tcgtttaatc tttccatttc 2175661 attaaacgat atgacggatt atgatttaac aaagctgtta aacattaccc aggaagaatt 2175721 ttgggattgg atgaatcaaa atgaagcgat catatataag gaagcattgc ttgcacagca 2175781 tgcgaaacag tctctcgatc ttctcaaaga ggagcacaag cttatttata ttacagcgag 2175841 acggactcat ttaactgata ttacttatga atggtttgac agacaaaaca ttcattatga 2175901 ccacatcgaa cttgttgggg gtcatcacaa agttgaagcg gtcaagaatc ataacatcga 2175961 cctgtttttt gaggatcatc acgggaacgc catgatgatt gcgaaagaag ccgggatacc 2176021 ggtgattttg ttcaattccc cttataatca gcttccgatt gattcaaaca tcatcagagt 2176081 aaacaactgg ctagaagccg ttcaatggat gaacaacaac aagcatcact taatacgcgt 2176141 caataactga aaaaggagcc caaaccgggc ccctttttca tatatacgca ttttacgcag 2176201 tagtgttttc ttggttttcc gctgtacaat cagggcatgt gccataaatc tcaaatttat 2176261 gcccgctgac ctgatagcca tccaaatcat cacaaagctt gtccatcgga catgattcaa 2176321 tttcctttgt tttgccgcag gcaagacaaa taaaatgatg gtggtgatgg gtgaatgaac 2176381 acttaaatcg gaagagcttt tcaccggaca gctcagttgt ttccaaaatc ccaagttctt 2176441 catataaaga aagatttctg tagattgtat caaagcttaa gcctggataa tcatcattca 2176501 gtgcagacag tacgttttta gcggtaagat atctgtctga atcagcaaaa agctgcagca 2176561 tatcctcccg tttgtttgta tatttatatc cgttttcttt taataggttc agcgcttctt 2176621 ggacgttcat gaagggtccc ccttttcgct ttgcttaaga acgtatcaca tgtatgaaaa 2176681 agaaaatggc agctgtctgt ccagcaagcc attttcttta ctgcagataa aattataccc 2176741 ataaaatgaa taaaagtaaa tgaaagccta gtggattgcg tttttgaatt ttccgcctct 2176801 cgtttcatga gtattcataa ttgttatgaa tgcattttga tcaacttcaa acacgatcga 2176861 tttgagcttt gtcacttcca gccttgtgac aaccgcgtaa attacgtctt tttcttcgtc 2176921 cgtatacccg cctttcccct tcagcttcgt tgtgccccga ccgagacggt gcaaaatcgc 2176981 gtcggaaatc tcatcatact gctcagacac aataatgaca gcttttgttt catcaagccc 2177041 ttggatcacg gcatcaatcg ttttcatcgc aatataataa gtcatgaatg agtacatcgc 2177101 ttgctcagga ccgaacacaa aaactgccca aatgaaaatg aacacattga tgaacataac 2177161 gaactcacct acagaaaacg ggagtttttt ggtcagcaaa ataccgagaa tttctgtacc 2177221 atccattgaa cctccatttc gaataacaag cccgacgcca aagccgagta aaagacctcc 2177281 gaacacagta gccaaaatag gctgggttgt aatggcttct acatggtgaa gtgaggattc 2177341 aataacggca agcccgacaa tccctataaa cgtagagact agaaaggtct taccgatata 2177401 tttatatccg aagatcataa aaggaatatt taatatgaca acgaaaaaag cgaaattcag 2177461 aaaggggttt gacataaaga ggtggtctaa aataagagat acaccgataa tcccgccatc 2177521 aataaaatca ttggggatta aaaataattc aatacttaca gccgcagatg cagctcctac 2177581 cagaatcata aagaccctga aaataaaatg ggtaaatgtt tctttcttat gttgttttgt 2177641 tggggtcata aaatctcctt tcctgcaata actattttaa atacattata aatctatttt 2177701 accattaaac actgacacat tttactgatt tgcccataca ttaagtctgg aggtggaatg 2177761 accgatgatt ttatttcaaa gaattatttt gcagcggctt aatcaggcta ctgctgatga 2177821 tttgctgaag tactcaaaac aatacggaat cagcttaaca agatcgcagg ccgttgaagt 2177881 agcgaacctg ttatacggga aaaatgtaaa catctttaat gagagtgaac gaatgcggct 2177941 gctgaaacaa gtagagacga ttacatcgaa agaaacagct caaacagtta atgaactatt 2178001 caaacaattt acaagctaaa aaatgggggt gttatccccc attttttatt gctgtaaaat 2178061 cttttcaagc aatgtatcat caaattgttt ttctttcagc atttcaatct caaaacggta 2178121 tggcggtttt ttgttctttt tatcttcacc gacgtatggt gtttcaagaa tttttggaat 2178181 gtcttttaac tgctcatggt gaacaacata ttgcagtgcg tcaaaaccta tttcaccaaa 2178241 gccaatattt tcatggcggt cttttctcgc acctttgaca tttttgctgt cattgatatg 2178301 aagcacttta atacggtcaa tgccaatgat tttatcgaac tcatttagca ctccgtcaaa 2178361 gtcttcgaca atgttatacc cggcatcatg tgtatggcac gtgtcaaagc acactgacag 2178421 ctgctcattg tgtgtaacgc cttcgataat ctgcgcaagc tcctcaaagc ttctgccgca 2178481 ttctgatcct tttccagcca ttgtttctaa tgcaatctgg acattttgat tcggatcaat 2178541 cacttcattt aagccttcaa taattttttt gatgccggct tcagctcctg cccctacgtg 2178601 agcgccagga tgaaggacaa tttgcttcgc tccgatggcc gctgtccgtt caatttctga 2178661 acgaagaaaa tcaacaccca gctcaaaagt ggacggattt gtcgtgttgc caatattaat 2178721 aatataaggc gcgtgtacga taatctcgtc aatgccgttt tcttgcatat gtgcccggcc 2178781 tgcttctata tttaagtctt caattttctt tcggcgcgta ttttgcggtg cgcctgtata 2178841 gatcataaac gtattcgccc cataagagac tgcttcctgg cttgcagcca gaagcatatg 2178901 ttttccgctc atagagacgt gtgagcctat tctcagcaac aggttcccct actttctttt 2178961 cttagattgg tttcttctct gttttttctt gattttctcc atctcatagc tcattttctt 2179021 tttataccca ggcttaacct tcttcggctt tttcacgaga cgatgagcaa tttcatccgc 2179081 ttcattcggc gtttttttac gttttttgcg gcgctgacgg tcatcgcctt ttttccattc 2179141 gcccttttca agctctaagt actcaaattc gatgcccatt ttttcaagtc ttactaatgc 2179201 atcctcatca gtaagctcat aaatggtcat cgcttgtcct gatgagccgg cacgagccgt 2179261 tctgcccaca cggtgaacat agaaatcgag atcatccggc agctcatagt tgataacatg 2179321 gctgacacct ttaatatcaa tacctcttgc ggcaaggtca gttgcaatga tatatgtgaa 2179381 ttccaaatca ttgatctgct tcatgacttt tttccgctca cgtggtgtta atccgccgtg 2179441 cagcaagccg attttcatgc ctttgccagt cagatactgg gcaatatggt cagccgtatt 2179501 tttcgtgttg gcaaacacaa tccccaggta tggattcaga tgcgacatga tgtcaaaaag 2179561 gagcttgtcc ttgtcacgat gtttcgaagg aatgaggata tgctcgattt tcgcagcagt 2179621 cacctgtttt ggctccacat gggcgtattt cggattttcc atgtatttct tcaagaatgg 2179681 tttcagcttt tccggtatgg tcgctgagaa cacaagcatt tgcagatcct caggcatgcg 2179741 ggaaccgatg taatctacat ctgcaaggaa tcccatgtcc agcattaaat ccgcttcatc 2179801 aataacaaga gattccgctt tatgaacact taacgcctgt tctttgatta agtcagcaat 2179861 ccgtccaggt gtaccgacaa caagatgcgg ctgtattttc aatttatcaa ttgatttttg 2179921 tttatcagtg cctccgataa aacatttcga gcgaatctga cttccttctt caccctgcgt 2179981 gattttaagc gcttcctgat aaatctggtt ggcaagctct cttgtcggag ccgtaatgac 2180041 tacctgaacg acatccttag caggatcgat tttgtttaat aaaggcagta aataagcgtg 2180101 agtctttcca gtacccgtct gagactggcc gatgacgctt tcttttttta acactgcagg 2180161 aatcagcctt ttctggatat cagtcggttc gtaaaaacca aggcgatgta ctgcatctat 2180221 aataaatggt ttcaattcat aaagttcaaa tttcgtttct ttcatttttc ccagctcctt 2180281 aaagcggcac attatgtgtc catcatcaca ttatacccga ttttgcttaa aaacaccacg 2180341 tttgcaaggc gtttgtttta ttcagttatg taaagcaaat accgcagccc atgcatattc 2180401 taatagcaga gagagctgaa aggaggtaca agtatgtttt caccgcagca gccaatgaga 2180461 aattacccac agcccggacc gccccgcccc atgccaaatc agcgaatgat gggcagaaga 2180521 ccgcctaata tgcgaggacc ttcatttgga gcacagcagc aaggttttca gcaagccgga 2180581 caatttcttc ctcaggcaaa tgccggagcg agaaatggtg caggtgcagg cggaggctta 2180641 aaaggaatgc tgtcaaggtt cctccccggc ggaggaggcg ctggcagcgc cggggttccc 2180701 ggaattccag gagcaggtgc agcagcgagc ggaggtgctg gcctgcaagg cattcaaaat 2180761 attgccaatc ctgcatcatt atccagtatg cttggaaatg tgcaaaaagt actcggcatg 2180821 gcgcagcaag tcacccctat gatccagcag tacggcccat tagtccgcaa tctgccagca 2180881 atgatgaagc tgtacagcca attaagtaaa agtgatgata ctgagacaga ggccaatgag 2180941 gaaagtgaaa aacaatccgt ttcagaagaa tcatcagaaa aagaaaaaga gactgaaaca 2181001 aaaacctcag atgggaacaa aaaatcaaaa ccaaaaagtt cttctctccc aaagaaatct 2181061 aaaacaactg acaataaaga acaagaatta aaaacatctg ccccgaagaa aaaggaagct 2181121 gcctctcctg ctccgaaaag aacatcaggc agttcaaaac cgagattata tatttaacat 2181181 tctttgatat cttaagtgag attggctata atgagatcag aagaatgcaa gaatagagcc 2181241 gtttgattac ggctttttat attgccttta ctcacttcag tattggagga caaccgaaaa 2181301 tggacgtaat taaaatttca ccgcgcggct attgctatgg tgttgttgat gctatggtca 2181361 ttgccaaaaa tgcgtcgcta gataaaagct tgccaagacc catctatata ctcgggatga 2181421 ttgttcataa taaacacgtc actgatgcgt ttgaagagga agggattttt acattggacg 2181481 gctctaaccg tctggacatc ttaaagcagg ttgacaaagg aactgtcatt ttcactgcgc 2181541 acggtgtttc tcccgaagtc agaagaatcg cagaagaaaa agggttagtc gcaattgatg 2181601 ctacatgtcc ggatgtgaca aaaactcata atctaatctt agagatgaaa gaaaaaggat 2181661 atcacgtgat ctatatcggc aaaaaagggc atccagagcc tgagggagcc gttggcgtag 2181721 cgccggagat cgttcactta gttgaaacag aagaagatgt aaagaacctt gatatccaat 2181781 ctgagaagtt aatcgtgacg aatcaaacaa caatgtctca atgggatgtt cacgacatta 2181841 tggagcttgt caaagaaaaa tatcctcatg tcgaatatca ccaagagatt tgcctcgcta 2181901 ctcaagtgcg gcaggaagct gtatcagagc aggcaaaaaa agcggactta acaatcgttg 2181961 tcggagaccc gaaaagcaac aattcaaata ggcttgctca agtgtcagag gaaatagccg 2182021 ggacaaaagc ataccggatc ggcgacttaa gcgaattgaa gctcgaatgg ctgaaaggcg 2182081 ttaataccgt tgcagttaca gcgggagctt caacaccgac gccgatcaca aaagaagtca 2182141 ttcgcttttt agagcagttt gatcacgaag atccatcaac ttggacaact gaacataata 2182201 taccgctcaa aaaaatactt ccaaaagtaa aagcaaaaaa ctgaggctgt aaaagcctca 2182261 gtttttttat agaaatgtaa atggatttgt atctgtttca gaaacaaaga tattcacgcc 2182321 aaacttttta tcattacaca ttgatgtaag ttttctcgtg acgccttctt tcatgatttt 2182381 ttccgcgtaa tggcccggat caaccacatt taggccaagc atcatcgcat catgggccac 2182441 atggaagtat aaatctcctg tgacgtaaac atcggctccc tttcgttttg catgatgaat 2182501 atacttgttt ccatctccgc caagaacagc tacttttttc accatgctgt cagcatcccc 2182561 aaccattctg acaccattga cgtcaagctt gtctttcaca aataaagcga attccttgag 2182621 cgtcatctca tttttaaggg ttccgacacg gccgagccct ttttcggcgg gagtctgttc 2182681 gacaggatag atatcgtaag cgacttcttc atatggatgg ctttttatca ttgcattgat 2182741 aacagccttt tcgacgcttt taggaaatac agtctcaagc cttacttcat gaacaagctc 2182801 aagctctccc acttcaccga taaaaggctt agctccgtcc aatggcttaa agctgccgat 2182861 tccttcagat gaaaacgcgc aatggctgta ttcaccgata tggccggccc ccgcatttcc 2182921 gagcgcggct ctgacctgct cttcatattc cttcggcacg taaactgcca gctttttcag 2182981 aggatccgta taagtaggtg ccagcacttc cgtctcactc agctctaatg cttcagcaag 2183041 caaatcattc acaccgccgt ccgcaacgtc taaatttgta tgagctgcat aaacagcaat 2183101 atcatgcttc aaacactttt caattaacct tccggcaggc tgatctgttg aaatatgctt 2183161 tagcgaccgg aaaattggtg gatggtgtgc aataatcaag tcaacctctt tttcaatcgc 2183221 ttcatcgata acgctctcta acacatcaag tgtaaccatc acatttttaa ttggtttgtt 2183281 taaggtgccg atttgcaggc cgattttatc tccttcaacc gcataggctt tcggggaaaa 2183341 ttgttcaaac agctggatga tctgctgccc atttacactt ttagccatga tcgattacct 2183401 cctttaacag ctccattcga tcggcgagct cctttaattt ttgtttgttt tgctctgtat 2183461 ccgccgcttg gctgatctgt tcataaatgc tttgagtgtg ctgaagctct tgtgtccact 2183521 ttttcaaaaa gacagcattt ttttcttttg ccaagaaagg gccaacgagc atcccggctg 2183581 ataaagaaat accgtcataa gccgcatccc tgtctcccgc ttctgccacc agcacctcat 2183641 agcactttcc gtcctcttca aggattacct catctatcag cgcatatctt tctttataaa 2183701 gccactccct gatatgaaca gcatgaatat tcggctgtaa aatgagccgt tccttccccg 2183761 ttaatttgtc tttgcccgct tctaaaatgt gagcgatcaa agccccgccc attccggcaa 2183821 tcgtaatggc atcagcttca ccttttttaa tcacttccag tccgtctccc tgccttacag 2183881 aaatgtgcga gtttaagcct gatttttcaa cctgccgctt tgcagacaaa aatgggccgt 2183941 ctgttatttc tccggcaatc gccccgctgg ctttatgatt cagcaccgca taacaaggaa 2184001 ggtaggcgtg gtcagagccg atatcggcca tcaccgctcc attcggtatg tactccgcta 2184061 ctgtttgcaa tcgtttagat aattttaatt cgttcacttg tcatcacaac ttttctcaat 2184121 cattttttcc tttactatca tataaaaaat cagcccggaa tccaagctga agcaaatgat 2184181 tttgaaatta tttcttttga tgcgggtctg cacgcagcag tcaaaaataa aaggctgtcg 2184241 agaacatctc ggcggcctgt gaatgtataa agagaaaaat agttctttta tttaattttt 2184301 gacacccact ctgccatatc atccagctta tcggccggaa caagaccgga aggcattcca 2184361 ttaccgcctt tttcgatctt tgttttaatt tcagcgacat ctttcttatc ccctacacct 2184421 tttaagctag gacccgaaac accttcataa ttttcaccgt ggcatgcgat gcagtttgcc 2184481 ttgtaaattt cttctggtga agcgtttgca tctttctttt cagcagattt gctttctcct 2184541 ccgctcgcaa tctcccgaga gtcatcaagt ccttttactg ataaaaagaa agttagacca 2184601 attcctaaaa cagcgatcag caaaaatgga ataagcgggt tccatttcat ttcccttccc 2184661 cctttttgat ccttccccct atgtaaacac ttctaattct aacttatttt tacaaaaagt 2184721 aaatggattg ctatacaaaa gttttttatt cacactttat acaaaattga atagaaacat 2184781 gcctaaatct ctaatatcct ttttattcta ttgtataatg tattgtatac gcttacaata 2184841 gaaaatatgg aattagattt tgaaattttt caccacaatg ttcatttgca aatgacatca 2184901 tttttcagta aaataaaggc atattatcca tatatctttt taaaaaaaga agaacggatc 2184961 ttcaagaccc gttccatctt attcaaggaa atctttcaaa cgtttacttc tgctaggatg 2185021 tcttagtttc cgcaacgctt tggcttcgat ttgtcgaata cgctctctcg ttactccaaa 2185081 tactttgccg acctcttcta atgttcttgt acggccgtca tcaagaccga atcgaagacg 2185141 caatacattt tcttcacgat cagttaacgt atcaagcaca tcttccagct gctctttcaa 2185201 tagctcgtat gcggcgtggt cagaaggtga agttgcttct tggtcttcaa tgaaatcacc 2185261 aaggtgcgag tcatcctctt caccgatcgg tgtttccaga gataccggct cttgagcaat 2185321 ctttaagatt tcgcgtactt tttcaggcgt taaatccata tcttccgcaa tttcttcagg 2185381 tgttggttct ctgcctaagt cttgcagtaa ttgacgctgc acacggatta atttattaat 2185441 ggtttcaacc atatgaacgg gaatccggat cgttctcgcc tgatcggcaa tggcgcgtgt 2185501 aatcgcctgt ctgatccacc acgtagcata cgtactgaat ttataacctt tgcgataatc 2185561 aaatttttca acggctttca tcaggcccat gtttccttcc tggatcagat caaggaacag 2185621 cataccgcgt ccgacatacc gttttgcgat actgacaaca agccgcaggt tcgcttcagc 2185681 caatctgcgt ttagattctt cgtcaccttc ttcaatcttt tgagcgtagg cgatttcttc 2185741 ttttgcagaa agaaggttaa cccgaccgat ttcctttaaa tacatacgaa ctgggtcatt 2185801 gattttaacg ccaggcggta cacttaggtc attaaggtca aattcttctt cggctttggc 2185861 aagctgctga atattaggat cttctgtttc ttcattctca ctaattaatt caacaccttg 2185921 ttcacctaaa aattcataat actcatccat ttggtctgat tcaatttcaa agctggacat 2185981 acgctcagca atttcttcat atgtcaaaac gccacgtttt ttaccagact ctgttaattg 2186041 ctcttttact tggtcgaatg ttaattctgt ctcgtgggtt tgtttatcag ccattatgga 2186101 tccctccttc caaagcttgc aacgaattct ataagcggta tgattcttat tcggtccatt 2186161 caggcgtttt ctatgtgaac tgcctttaac aatgtgcgaa taatgaaatg acaattcatg 2186221 atgaggttaa gcgatctatt tgctcctccg caaggaatca ttgccaataa atgctcctca 2186281 tcagttctcc agttatttta aagatcggtt caatgtaacg atttcttgag ccaaagaagc 2186341 agctcttaaa aaatcttttt gcctttctgc ttcggctctt tccgcctctt tttcttttat 2186401 cattgaccaa tttctttgat tcaacacttt ttttacataa tctgataact cggcttcgct 2186461 aagctcttga ttaacctgaa gcattaatat atcggacaag agctggctta tatgatcatc 2186521 cgtcaccctg gccatcagat gctgaggcgt cagctcggct ccctcttcat aaaaagcata 2186581 aagataagcg gctaatgccc ggtgctcatc aatattaaat tgaaacccta cccggtcaat 2186641 cacttttttg atgacgctcc gatctcgaag catgtgagcg agtaacagcc tttctgcatt 2186701 ttcatacgcc ggacgcaaac gtttttgcct tgcttttgtc gtcagatgcg ctcgccgcgt 2186761 tttagtttca ccgctattgt cagcaggttt gttttgcttg ctgaaaacag acagctgctc 2186821 agttaaagac tcctgtgaaa gcgaaaactc tgaagcaagc tgctttacat agacttcctg 2186881 ctctagagac cctgaaagcg tgctgatttc tttcagtacg tctttaatgt aagctaggcg 2186941 gtcgccttca tcggacaggt tctttccttt tcggaaatat tgcattttga acgccattac 2187001 ggtgacactt gcgtcaataa tgtcgttttt aaatttttcc ccgccgaatt ttttgatgta 2187061 atcatcaggg tccaatccgt caggaatcat tgcaactctg actttgcagc cttttttttg 2187121 cagaagctcc gaagctttta aggtggcttc ataaccggct ttatcagagt catagcaaag 2187181 aatgatttct tcgacgtttc ttctcaggat cttgacatga tcatctgtaa gagacgttcc 2187241 catcgtggct atgctttcct ttacatccga gcttacggcc gatatgacat cagcaaaccc 2187301 ttcaaataag actgctcttt cctgctttct gatatgaagg cgggccttat aaaaattgta 2187361 aagcagtttg cttttatgaa agagcggggt ttcaggactg ttcatatact taggctgctg 2187421 gctgccaaga gccctgcctg agaaagcaac aacagccccg tgatgatcat ggatcggaaa 2187481 catgacacgg tttctgaagc ggtcgaaata tccgcttccg tcttcgcgtc tgatcaggag 2187541 acccgctttt tccatttgcg cctcactaaa tcccctcttt acaaggaatt tcgtgataaa 2187601 gtcccaagaa tcaagagcat agccaatctg aaattcatta atcagctctt tcgtaaagcc 2187661 cctagaaagc agataatcca gtgcctcttg accttctttt gtatttatta acaaatgatg 2187721 gtaaaatttc ttcaggagct catgtgcctc agccattttt tgttctccag aagactctgg 2187781 ccgggctccg gaatggactg ttatatcatc tggaaaatca atttggtatt tgtcagcaag 2187841 gtgagaaacc gactcggcaa aagaatagcc ttccatctgc cttaaaaaag agaaaacatt 2187901 gccgcccgct ccgcagccaa agcaatgaaa aatctgtttg tcgggcgata cggaaaacga 2187961 aggtgtgctt tctccatgaa aaggacagag tccaaagtag tttcggcctt gcttctttaa 2188021 ttgaacataa tcacctatga cttcaacgat atctgccgac ttttgcacct gatccacaat 2188081 ttcatctggt atccgatttc ccatcttata acactccgtc gtacattatt cgatgcttta 2188141 gtgcaaaatc ccttcatcgt tcgacaggat tttttgcagc agtgtaataa atcgttctcg 2188201 atcttcttta ttcaattttt taggcccttt ggcatatacg ccttttcttc tttgtttgcc 2188261 ggaaaaatga cggccctcta gggcaaaatc aatcgtgtct tccttgtaaa gacgacctct 2188321 ttccgacata acagagacat ttctgttcaa cagcagagat gctaatccga tgtcctgcgt 2188381 cacaacaata tctcccggtt tcacgtgatt tgcgatatat aaatcagcag cttctttatg 2188441 aggatcaaca tacttccatt tttcttcatt gcttctggaa agctgataat gttcaaatga 2188501 agcgacaaaa agaacttgaa cttcatactc ggatgctgtt tgtaaaattt catcttttac 2188561 cggacaagca tcagcatcga caaaaatcgt cttttcttgt tcattaagaa gagtaattct 2188621 ccatccctcc attaaactcc tgcataaaag caagcaaaat cgcacatcct ttattattgt 2188681 ggatgtatat gaatttgtcg aaaaatttcc gggagaaatt cttgacatct tacccataat 2188741 agtttattcg tatcacacga tccttaaacc taaaattaat cattttatca caatttttta 2188801 ttataataca aacttcacaa agatgctatt gtttttcatt attccctttt ggcacagcca 2188861 aaaacccagg atagagcgtc ctgagttata tgttttttgt tttgagatga tggataatat 2188921 ttgctgtttc ctcaaccgct ttatttgaaa catcaacaac ctggcagccg atccgatcca 2188981 caatcttttc gaaatactcg agttcctctt tgattctgtt gatatttgca taaatcgctt 2189041 tatcattaag cccgagtgat tttaaacgtt cttttctgat atgattcagt ttatcagggc 2189101 taatctttaa accgatgcat tttttcggat caacgttaaa gagttcttcc ggcggatcaa 2189161 cctccggtac aatcggaaca ttggcaacct tcaggcgttt gtgtgcgaga tattgagaca 2189221 gcggtgtttt agacgttctt gacacgccga tcaaaacgat atcagctttt aaaatccctc 2189281 ttggatcacg tccatcatcg tatttaactg caaactcgat ggcctccact tttttgaaat 2189341 aatcttcatc aagctggcgc acccgccccg gttcgtattt cgctgttaaa ccgtaggctg 2189401 tttccatttt atcaatcaac gggccgataa tatcataata taaaacattt gctttttccg 2189461 cttcggctat caaatattct ctgatttccg gcaccacgag tgtaaaacag ataatgccgc 2189521 cgtctgcctt tgcaagtgaa atcacttcat tgatagtgcc tatatcttca acataaggaa 2189581 ttcttcttac atgagtatca tccgccgatc cgttaaattg gctgagtgct gcttttacta 2189641 ccaattcagc cgtttcaccg acggaatccg atacaacata gatgatgcgg ttattcatat 2189701 tatccccccg ttagtttgca atcttatagg atttcatttt cagataaact gacaagtatt 2189761 ttggtcatat ttgtttttgt cactctgccg atcacttcaa agcctttatc ggtgtctttg 2189821 atgacaggca gtgcatcaat ttgtttttct attaagtgct ttgcaatgtc catcacataa 2189881 tcctcgcgtc tgcacaccgt aatgttcggc atccttgtca tgatgatgtg aacagggacc 2189941 gatgtaagct cctgctggcc aatgctcgct ctgagcaagt cttttcgtga aagcaccccg 2190001 actaaaacag catcgcggtc caccacaaac agagtaccta catcttctaa aaacatggtg 2190061 caaatcgcat cgtacacaga aacgttttcg tgaatcacta cggggataga ttgaaagtct 2190121 ttcacctgaa gctttttgag tttatccgcc aaaagctgtg tgccggtttt tcccgtatag 2190181 aaataaccga ctctcgggcg cgcctcgagg aatcctgaca tggtgagtat ggctaaatcc 2190241 gggcgcaatg tcgccctggt taggttcagc ttttctgcaa tatgctcccc tgtaatcggc 2190301 ccgttttctt ttacaatctg caaaatatgt tcttgccgtt tatttagttc gatcgtactc 2190361 accacctttt cacttcatag ctatgtaaag aaataacaat ccatattata acgtaaatat 2190421 cttgtaatca aacaaaaaac ttataaatgg ggaaaagacg attaccgatc acacagcaac 2190481 cgccttttct ctctttattt tacaataagg gcattcatat tcgcaaagga cttgatctca 2190541 tccgccaagc ttaccatttg cgctaaacga tttgccttta atgactcatt atccgctata 2190601 accattgtat gatcgaagta agcatcgatc ggttctttta aggctgcaag tgaagcaagc 2190661 gccgcctcat aatctttttt gctgaagttt tcctgcagat tttgcttcgc tgtttggtag 2190721 gcatcaaaca gttttgcttc gtattcattt tcaaacagat caggctgaat gtctccgcgg 2190781 actccttttt tgctgataga gatcactcgg cctaacgctt cggctgtttc cttaaagcca 2190841 ggtgcaccaa gcttttgctc cagtacttgt gctttatgca gcgcagagta cggctcaagc 2190901 tcagagcttt ccagcacggc gtcaatgaca tcatgtctga tttgttcagc attcaagaca 2190961 tatttcaagc gctgagtgaa gaaatccagc agttcatttt ctttatcggt ttgaacgaaa 2191021 gtaagcagct cttcaaatga aattccccag ttgcggtcaa gaagaatcgc aacaataccg 2191081 cttgcttggc ggcgcagtcc gtaagggtcc tgggaaccgg tcggaattac gccgatagag 2191141 aagaatgaag cgattgtgtc aagcttatcc gccattgcta caacagctcc ggtgaaagta 2191201 gaaggcgttt ctccgcccgc tgatctaggc atataatgtt cattaactgc cgcagccaca 2191261 gcttcatctt cgccaagcat tctcgcatac ttttcgccca taattccttg aagttcaggg 2191321 aattcatata tcatatgcgt cacaaggtcg aatttagaaa tttcagcagc ccgcttcaca 2191381 tgttttaatg tatcttcatc agcctgaaga cgaacggcaa gtttctctgc gattgatgtg 2191441 actctcctaa ccttatcagc aagagaacca agctcttcat ggaaaacgat attttcaagc 2191501 ttcttcacat ttgcatcaat gtttagtttc tgatcttctt tgtagaagaa tgaagcatca 2191561 gataaacgtg cgcgcagcac tttttcattg cctcgggcca cattttcaat cgcgtggctg 2191621 ttgccgtttc ggactgtgat aaagtgaggc agcaggtcac cgtttttgtc tttgacaggg 2191681 aagtagcgct gatgctcttt cattgtcgtg acaagcactt cttcaggaat tgacagaaac 2191741 tcggattcaa atgaaccgta aagagctgtc gggtattcta ctaaatgatt cacttcatca 2191801 agaaggtctt cgtcaactgg aatgctccaa ttgttttcag cagccattgt ttccagctga 2191861 gattgaatca tttgctttcg gacgctagga tcagcaataa catgctgtcc tttgagctgc 2191921 tcttcataag ctgaaggtga ttcaattgac acttcatgtc cgaggaaacg gtgtccctgt 2191981 gttgtccgtc cagactcaac gtttgtgatc gaaaatggaa tgacatcctg tccaaataat 2192041 gcgacaatcc atttgatcgg tcggatataa cgcaaatctt catttcccca gcgcatgttt 2192101 ttcgggaaat gcaagcttgt aattaaaccg ctcaattctg gcagaagcga cttcgtttct 2192161 tggccggctt ggaatttttg cacgaataca tactctatgc cttttacttc tttgatgtac 2192221 aggtcttcca catttgcgcc ttggcctttt gaaaagccga ttgccgcttt tgtccagttc 2192281 ccgtccgcat caagggcaat ttttttcgca ggcccttttg cttcttcttt tatatcatcc 2192341 tgcttttctg cgacatcctt aacgaacaca gcaagacgtc tcggtgtatt gaagagtttc 2192401 acttcaccgt gagtaatatt tttttcttta agccagcctg tcagcttgtc gccaagctga 2192461 accatgcttt cattcaaaaa gcgcgccggc atttcctcta atccgatctc taaaagtaaa 2192521 tcctgtttac tcatgagaag aaccctcccc tttaagcatt gggaacccta gtttttctcg 2192581 ttcctcatag taggtttttg ctacttttct agctaaattc cgcactcttg cgatatagcc 2192641 cgtccgctcg gtaacagaga tcgcaccttt ggcatcaagc aggttgaaag tgtgcgagca 2192701 tttcagcaca tagtcatatg ctggatgaac aagtccgttg tccatttgct tgatcgcttc 2192761 tttttcatat gtgctgaaca attggaacag catatcgacg tctgatgttt caaacgtata 2192821 aacagaatgc tcatattcag ccatcatgaa taaatctttt actgtaaacc ctgacgtcca 2192881 ttccaagtca aacacgtttt ctttatcctg gatataagac gcgagacgct caattccata 2192941 cgtaatctct acagaaacgg gtttacactc taatcccccg acctgctgga aatacgtaaa 2193001 ttgtgttatt tccattccgt caagccaaac ttcccagcct agacccgcgc agcctaaaga 2193061 cggattctcc cagttgtctt caacaaagcg aatatcgtgc tcaagcggat caattccaag 2193121 agcacgcaag gaatccaaat acagctcttg aatgttatca ggtgacggtt taataatgac 2193181 ctggaactga tgatgctgat acagtctgtt cgggttctcc ccgtagcggc cgtctgccgg 2193241 acgtctggaa ggctctacat aagccacttt ccacggctca ggaccgatac tgcgcaaaaa 2193301 tgtatacggg ctcatcgtgc cggctccttt ttctacatcg taagcctgca taagcacaca 2193361 gccctgactg gaccaatgct tttgcaaggt tagaatcatg tcttgaatat tcatttcaag 2193421 cacctccact tttctttcat aagttgactg cggcagcaac caaaaaactc ccgtctctat 2193481 gcttgccagc cgcaaacata gggacgagag ttctcccgcg gttccaccct agttgctgag 2193541 aacaaaatcc cagcctcttt tttaaaattg ctcaagaatg cctttcgttg cgtgctcatc 2193601 cttagcttac accgccctaa ggtcgctttc atgaggtaaa cgcaagtact tctttctctc 2193661 actgcaacat attttataat aaatgatcat ataaaaagat ggaccaaatg tcaacttttg 2193721 ttttcaccca taagatgttt catgctttcc atttgatcta aaaagcgctt tgattttaaa 2193781 tacaatcccg aatattcttc gtaatataaa tcaatcactt gctttaattc agcttttgtt 2193841 tcctctttta aggacacatt gccgagtctc gacagatcaa aatagtaaaa gagccttaac 2193901 agccttgccg tttgcggttt aatcggtatc ctgtaaggat ctttttcaaa acagcggtgg 2193961 catataaaac cattatcacg aacagagaaa tgaaaggttc cgtcttggct tttacaatgt 2194021 acacaatgat tcagctcagg atacaggccc atgacaccga gcatcttcat ttgaacaatg 2194081 aaggtgataa catccggatc tgttccttca ttcaactgtt ttaatgattc taatatgaat 2194141 tcaaataaat aaggatttgg ctttttttct tctgtgcctc tgtcgactaa ctcagcaaca 2194201 taggcagcat atgctgttaa aaacaagtct tccctgatgc ctctcatgct gaggatcatt 2194261 tccccctgct gaagcgttcc gaggcccgat gttttttgca ttaagaaaga accatacaaa 2194321 aagggctggc tgactgctga taaacggctg ttcggttttt tggcgcctcg tgccataaca 2194381 cctatttttc cgtgttctct tgtcagtaat gttacgattt tattcgtctc tccgtaatca 2194441 tttgtgcgaa gaacgatccc ttcacatttt gtcagcattt ccgcaccttc ctcaagcagg 2194501 agcggccaag aggtttataa aattggataa tcaaatcggg ctagctcatc ttctagttct 2194561 tcgggtcttt ccatgttctc tttttccagt tctttaaaaa gaagatacgt atcaacattt 2194621 cctgtttgag aaaatacgtt ccaggtaaaa ttcaacacaa gaaacccacc tttctgtagt 2194681 taaactagct tacctaaact ccaaattctt acctttatct tgaccagatg tcctccattt 2194741 catgttaaac aaaatttgct aatgtatccc tgttcctgtg agataatgac acacacggga 2194801 agagattaat attcgtcctc tttaaagcca aaatcgcgaa gctgggacat tttattacgc 2194861 cagtctttct gcactttcac ccacaattca aggtagacac gggagcccaa cagtgcttca 2194921 atatccgctc tcgctctttt tccaacctct tttagaaggc ttcctttttt accgatcacg 2194981 atgcctttct gggaatcccg ctcgaccaca atcgttgccg ctacgtgcac agaaccgttg 2195041 tcctgccctt tgatggattc gatggccacc gcaatgctgt gcgggatttc ttctctcgtc 2195101 aaatgcagca ccttttccct gattaattca gaaatgataa atcgttcagg gtggtcagtt 2195161 acctggtcac tcggatagaa ttgcggccct tccggcaaat acgcttcgat ctgcgcgagc 2195221 aaggtttcga tgttatttcc ttctaaagca gaaatcggaa caatttcctt aaaaggataa 2195281 cgtttgcggt attcgtcaat tagcagaagc aattggtcgg gatgaatttt atcaattttg 2195341 tttacgatta agaatacagg cgtagacatc gtctgcaatt tctcaatgat gaattcgtcg 2195401 cccttcccgt agccttcctc agcattgatc ataaacaaga tcaaatcgac ttcttttaat 2195461 gtattttgcg ccactttcat cataaagtcc ccaagtttat gcttaggttt atgaatccct 2195521 ggtgtgtcaa taaaaatggt ttgtgatgtg cctgtcgtca gtactccttg caccttgttt 2195581 ctcgtcgttt ggggcttatc gctcatgatc gcgatttttt gtccaatgac tctgttcaaa 2195641 aatgtagatt ttcctacgtt tggtcttcca ataatggata caaatcctga tttaaagctt 2195701 tcgttcgtca tgtaaatcct ccgatgaaaa tgcgcctggc aataattctt ccacagtcat 2195761 ttcttttatt tgtccttgta aattagtcag tacgacaata acgtcttttg tgcaaagctc 2195821 agaaatcacc tgtcggcagg ctccgcacgg agatactggt ccaggggtgt cagccgcaac 2195881 ggccagcatc tgaaactctg tatccccttc agaaacagct ttaaataaag cggtacgctc 2195941 ggcgcaattg cacatgctgt atgccgcgtt ctcaatattg cagcctctgt acacttttcc 2196001 atccttggta agaagagcgg ctcctacttg gaatttggaa tacggcgcat atgccatatc 2196061 acgcgctttt aaagcttctg ttattaattc ttgtctgttc atgtgtacat tcctctctta 2196121 cctataatgg taccgctatc actttatatt ttacataatc gcgcgctttt tttcacgccc 2196181 atttctaaaa atgtaaaata aatgtaagaa ttttcagcca ttacagcttt ggcaaaaaaa 2196241 taagtaaacc aatgatacac gaaatcacgg caaaaacgca aacagccccg gcggcagcgt 2196301 ccttggccgc tttagcaaga gggtgatgtt tgtcagttat taaatcaacc gtatgttcaa 2196361 tggctgtatt taaaagttca agcgaaaaca taccacctat caaaaggaat ataatcatcc 2196421 actcaataat gctgagctct acaaggaagc cgcaaatgag aacagcgcag gcggctgcgg 2196481 catgaaattg gaaattccgc tccgtccgcg ctgtttccca tatgccccgg cctgcatgca 2196541 cgaagctttt gaagaatcga ttcagctcat ttctatgatc ttttgagtcc ataagcgtcc 2196601 agcaattcct tttgcttagt aaacatctcc tcttcttcct ctttcgtcat atggtcatat 2196661 cctaaaaggt gcagaaatcc gtgtacagct agaaatccga gctctctttt aaaagaatga 2196721 ttatactcct ctgcctgctc tcttgtgcga tcggcactga tgataatatc acctaaaacc 2196781 ggaggcattt cggcgcccac gatttcgatc tcgccttctc cctcttcttc aagagcaaat 2196841 gagatgacat ctgtcggagc atcctttccc cggtattctt tgttaatctg atgtatgtca 2196901 tcattggaaa caatcgtgac agaaacttca gcctgatcct gaacgccttc acgctcagcg 2196961 gcaaattgaa gcagattttc tacttctttg agcatctctt ctgagacgct tcccgtttca 2197021 tcaacgatat caatcagtaa actcatctat ttcaccttct tagtagcctc cggatattca 2197081 atccgggagt ggaaaattcc ttttaatgtt gcacagagcg tttttgcgat tgtatccagc 2197141 tctttaaatg tcaaatcgca ttcactgaac tgtccgtcct gaagcttatc ggatataata 2197201 ccccggacaa gcttttcaat tcgttcagga tttggattgt gcatggatct gacggccgct 2197261 tcaacactgt cggccactga tataattgcg gcttcctttg actgcggctt cggtcccgga 2197321 taacggaact cttcctctgt aatctggtcg cctttttcct tcgctttata gtaaaaaaac 2197381 tttaaaagcg aggttccatg atgctgctca gcaatatcga caagctcttt cggaaattta 2197441 tagcttctca gcatattcgc accgtctgtc gtatgcgaga taataatatt tttgctcaac 2197501 tgaggtgaca gcttgtcatg cggattgtca atattcattt ggttttcaat aaaatattgc 2197561 gggcgctttg tttttccgag atcgtgataa tatgcgccga ctcttgcaag caaaccatta 2197621 gccccaaccg cttcacaggc tgcctctgat aaattggcaa ccattacact gtgatgatat 2197681 gtacctggtg tttccgtcag tattttgcgc aatagcggat ggttaggatt agacagctcg 2197741 agcagcctca tggtggataa aatgccaaag cccgtctcaa aaaacggcat cagaccgatg 2197801 atcaatacag atgaagcaaa ccccgacaca acccccatga gcattaacgt gccgatttca 2197861 agacccgaca gcgcagtgtt ctggatcaat aataaggata gaacgacaac catattaata 2197921 aacgccacga aaagtccggt ctgcaaaatc tttgatcttg cattgtgttt tcctaaaaat 2197981 aatacacctg aaatgccgct gatcaaataa taaatcccta tgacataatt gaatgttcct 2198041 gtcacaccct gattaaacat catacttccg caaatcgcaa gaatgatact tcccaaaatg 2198101 gcaatgcgtt cattcatcag cagtttgatt aagatggcgc cggccgcaat ggggaccaga 2198161 tagccgatat tattatactc catcttctga aacaaactga caacctccat gatcacaagc 2198221 aaaagtgttg tgattatgga gaataacaga atggattggt ttttaaactt cagattttgt 2198281 ttctgttttt caaaataata tacaagtgtt gcaatgaaaa gtccgatcat aatcaatagc 2198341 ccgctgatcg gtttaaagag atttgagtta tttaataacc cggtcagctc aagtttcctg 2198401 tacacttccc gatcaatgag gtcattttct tccacgagca cttgcccctg tttgatttga 2198461 acctgctgga cattatctga ggcttcctgc cgttttgcct ctgttgcttt cggatcgaag 2198521 acgtaattcg gaataatagc aaaacgcccg atttctgtcg cggctcccaa gtatttagac 2198581 ggaatagaat tgctctttag ctctttttct accttatcct ttgcatcaga tagtttatcc 2198641 gaagggattt cactgctcat gaccgtattt accgcggtaa tgaccgtatc tctgacaaaa 2198701 gaaaagtctt cactgtctgc tttcagcaat gtcttgatgg aatcctccga tatagaatca 2198761 ttcacatctg atgtcaattt gtcctttaca gatttgacca ttgatttttc cgatggtgat 2198821 ttactgcctt cttccgatga ttttttcact tcactaatac tgtcgaatat tgatgacaca 2198881 aggtcaatcc gattgtctgt atattctttt tttaatgtat attgatcttc aaccgcgtcc 2198941 tcagcggctt gctttttttc ctctgtggct ttttgatctt ctacggttgc cggagcgtaa 2199001 atggtcttgt cgctgactga aaacaggtct aaatcaagtg tttccggctt aacatgtaca 2199061 aagagcaaag caaacataat ggcagccagc agaagataca gcagtacatg catggagcgg 2199121 gcatttttaa aactgctcca tttttttgag ctgcttttgg tcttagcctt ctttttcaac 2199181 acaagaacct cctcttgaaa catcaagccc ataagcaatc ataaaaatga cccgataacg 2199241 cgcgatcggg tcattcagca ttaattttgc ttatcgtatg cttcaataat tttcgcaaca 2199301 agcggatgtc tgaccacgtc tgtctggtct agctcaatca tagaaatgcc gtctattcct 2199361 ttcagcatct ccttcgctac tgcaagtccc gatttgacgc ctttcggcag atcaatttgg 2199421 ctaacgtcac ctgtaatgat cattttagag ccaaaaccca gtctcgtcaa aaacattttc 2199481 atttgagcag gcgtggtatt ctgtgcttca tcaagtataa cataagcatc atcgagcgtc 2199541 cgtcccctca tatatgcgag cggagcaatt tcaatgatgc ctctttccat cagacgttct 2199601 gtatgatctg ccccaagcac atcatggaga gcgtcataca gcgggcgcaa ataaggatct 2199661 actttttctt ttaggtcacc tgggagaaaa ccaaggcttt caccggcttc cacggcaggt 2199721 cttgttaaaa tgattttttt gatatgtccg ttttttaaag catggactgc ttttacgaca 2199781 gccaggtacg ttttcccggt tcccgccgga ccaatgccga atacaaggtc attccgcttc 2199841 atagcggcca cgtattcccg ctgtcccatt gtttttacac ggattgattt gccttttgcg 2199901 ttttttgtaa tttcttcttc atacatgctt tcaaagtatt caagttcatt cttctttgcc 2199961 attttgatgg cgtaaatcac atcacgttca gagatctcta tccccttgcg aattaaagcg 2200021 aggagcgatc ccagcagcct gtctgcaatc tgaaacgatt catcatcgcc tgaaacataa 2200081 atcgtctcgc cgcgcgtaat gatatttaaa ttcagatctt tctccatcaa tttcaaaaaa 2200141 gaatcttggt tcccgaagag tgaaagcgcc tcgtccgggt ttttcagttt ttgattcatc 2200201 gcaagtaaat gttctgtcat tcttcagtct ccctgacaat aggtgtggtt tgaacgatat 2200261 cttctataac ttggtagaga ataatcaact ttactttacc attctcaaca gtctggtgca 2200321 aaactttttc acttttcacc tcgccgtttt cgcctatttt atcctctaca tcctgtttac 2200381 ccaatttaat gccttcttga actgcttctt cttttgtata ttttcgcaaa gcctcttcac 2200441 tttctctcgt ttgctctttg acataggata cagggagctt aaatccgaga aaatgaagcg 2200501 aatgcttttc ttgttctgtt tttggatgct tcaattcctc ttttttaaac gtcatccccc 2200561 agatcgggat tgccaaagaa ccaaaagaaa gcttgtgctt tgtccttact ttgcccgtat 2200621 agacgttaaa taatgtttca agcgggactg tcacttctga tctataccag gtttctccat 2200681 aaatttctgc ttttgaggcg acttcctgct gatggtcttc gctgccgatc agtcccgaaa 2200741 caagcagctg tcccttttca acatgatcgt gtatggcggc catgggctgt cctttttgca 2200801 caaacattct cgtaatggtt gctttctttt tggcgacaat attgcgcggg ctaacatatt 2200861 tttctttttc gggctcattt ttctccacaa ctttcatatg aatggtcgtc cccttcagat 2200921 caactccgac ccaagtgata ttgtctattc cattggttaa tgatttctgt attttttcgg 2200981 gcgacatcat taaaaactgc agacggccct ttttgacgcc gatttcatta agatgctgcc 2201041 tcatttgatg ttctgtttca ggcttagcgc ctgtcacatc aattttccac accatattgg 2201101 acagcaaaaa caaaagaatg aaaaaaatcg caaaaccgat cgtaaaccct atattcagct 2201161 ttgatttcag caacaggaag ggaaatccct tccgattgat aaatcgggct ttacatttaa 2201221 atttacttct tacccgccga aaggcatgta catcctgaag ctgtatatat aacgatacgg 2201281 cttctttctt ttttttgaca tgaaagaccg gaatcccctg tcttgtgcat tcattaagga 2201341 gccgctcaat ccctcttccc gtcaattcaa gctggacctt acccgaaaaa aaagacagcc 2201401 atttattttt cacaacattt ccccctcggc tttatgactc aacatatcga acgacatcaa 2201461 tcgtaccctc caaaagtatc tcttccggaa gaatcgcctt gatgacaaaa tttttaccag 2201521 atatgatgca ctggccctgc ttcagcatca gccgcacttc attctcactg aaaagcaaaa 2201581 ggcctctgtg gttttctatg tagatatgaa gtctgccaac cattgtaatc ctcggcagat 2201641 ccatcataac gtccggggga atttccaatg ctcttgtcag ccaagctttc atacgattct 2201701 ttctttgccc catacaaaaa gaaccccctt tcatctcata tgtatgattt gaaaggaggt 2201761 tctaacactt taatttttac gggccgggcg catcgtacgg tgaggttttt tcgcccgtgg 2201821 aggtccgaac acctctccta gaacgatccc ctgtacgacg gtgtctttat tcacctgaag 2201881 cattttttgt tttgtgtata ctgttttttg tttggcagca gcaagatctc gttccagccc 2201941 tttcaggttt cttgctgttt ccctgcgtct ttcttccgct tcccgtcttg cctgttccat 2202001 acggttaggg ataggtgcag gggcatcttc ttttgactgc ttcttttgag gagaagcaga 2202061 ttgcacgtgt tgaggttttt ttcttttttg gctgttttgc ttttcttctt tgctcttttt 2202121 gccgaaaatc gcagaaatga ttccgatgat cgctgcaata ataagcggat tggtcagtaa 2202181 atcttccatc agcgttctcc cttcttagag agattatgat ttgcggtctt catccgaagg 2202241 gtctttcgtc agcttgccga atgaatcacg catttctgtg tcagcatcga tgttcttgat 2202301 attcatgtaa tccatgacgc caatattccc ttcacgcaaa gcttctgcca tcgcaagcgg 2202361 cacttccgcc tcggcttcta ctactttcgc gcgcatttct tctacgcggg cacgcatttc 2202421 ctgttcttga gcgacagcca tcgcacgtcg ttcttccgct tttgcctgcg cgatgttttt 2202481 atcagcctcg gcctgatcgg tttgtaaaat tgccccgatg tttttgccga tatctacatc 2202541 tgcaatatca attgagagaa tttcaaacgc agttcctgag tccaatcctt ttccaaggac 2202601 tgtctgagaa atcatgtcag ggttttcaag cactttttta tgattatcag atgaaccgat 2202661 tgtagaaacg attccctcac ctacacgagc tacaatggtt tcttcccctg ctcccccgac 2202721 gaggcgctcg atattcgctc ttactgtgat tctcgctttc gctttcactt caatcccgtc 2202781 cattgcgacg ccggcaatga acggtgtttc aatcacctta ggattaacgc tcatttgaac 2202841 agcttccaac acgtcccggc ctgcaagatc aatggcagca cagcgctcga atgtgagttc 2202901 aatgttagct cgctgagcgg cgataagcgc gttgacgact ctgtcaacat tacctccagc 2202961 cagatagtgg ctttcaagct ggtttgttcc aacattaagt cccgctttat gcgctttaat 2203021 cagcgggtta acaacccgat tcggaatgac gcggcgaagc ctcatcccaa ctagagtgaa 2203081 aatgctgatt ttcactccgg ctgccaaagc tgaaatccaa agcattacag gcacaaatgt 2203141 aaaaaatact gccaaaacaa tgatcgctac tgcgacaatt gccagaatca taagtgttga 2203201 cggatccata taacttctcc tcgtttctat ttaaatttct ctcacgacaa tgcgtgagcc 2203261 ttctactttt atcactttta cttttttatc tttttctgta aacgatccct ccgatacaac 2203321 gtcaaggcgt tcatcatcaa taatcacggt accggaagga cgcagcggtg taaaggttat 2203381 acccactttt cccattaagt ccgtgcgcgt ttgatttgaa acgtagccgc tctccgtgtt 2203441 tgtagaatca tttaatatca atttcttaaa gaatttcata cgctttccca acacccttgt 2203501 cagtaaaata aaagctgtaa tcgaaacagc tgaggcgatc aagagagaaa ccgccatgac 2203561 agtgaagctc cccgcggcta aaaacaggct cgcaataatc gctcccaagc ccagtaatcc 2203621 aatgattcct ccgggaagaa aaatctcaag cagaatgaga atcacccctg ctataaagag 2203681 gagaaccgtc tcatacccgg caaggccggc tgcaagatgc ccgtaaaaga acagcaataa 2203741 cgcaatgagt ccagccgttc cagggaggcc gacacccggg gaaaaaagct ctaccgtcag 2203801 acctaaaaaa gcgattgtca gcagaatagg gacaatgacc ggattcgtca gccatcttgc 2203861 cgtcttttcc gcaaagctct cctttgcata gctgatctgc gccttttcga acccaagctt 2203921 ctttacgagc gtggacaaat tgtcagcagt gccttctgaa tagcctacct caatcgcctt 2203981 gtctgcgtta agtgtcagca gatctccctt aggcgcgcca acttccttgg catctatatc 2204041 tgggtcagcc attgcgagcg catattttgg atcgcggtta tttttcactg cggcatcttc 2204101 catctctgcc agccaaagtg attgagcttt ttggtcagcg gcattgcctt ggccatcaac 2204161 aatcgcggcg gctcccattt ttccgccagg cgccatataa atgtgatctg cttgaagtgc 2204221 aatatatgca ccagcagaca acgcgcgttt gttgacatat gcagttacgg ggatctcgct 2204281 ttcggttatc aaatcggcca tatcaatagc agatttgacc aatccccccg gggtattgat 2204341 atcaagaata atatggtctg catgtgcatc ctttgcgtct tgtaacgaac gggacaaaaa 2204401 cgaggcgaga ccctgttcga catttttttc aaccgggatc acataaacag tttgtttttc 2204461 tgcttttgcg ttcagctgta cgcctaataa agaaagtaaa aatataccca aaagagcagc 2204521 acggaatcct ttgatttgaa gcaagggcgg tgtatccctc cttcctttta taataagtgc 2204581 cttctcttca tacgtaacaa atgtatcaaa ggtttcattt ttttatgtat aaaaaaagac 2204641 atctctctta gaaagatgtc cttttctttg ccatttaaga cagttgactg ctcacaagct 2204701 tattaattaa acttccgtca gctttacctt ttactttagg cataattgcc cccatcactt 2204761 tgcccatgtc cgcttttgag ctcgcaccga cctccgcgat ggtttcattt acgattgtac 2204821 gcagctcttc ttctgacagc tgctcaggta aataaacttc taaaatgtcc agctcttttt 2204881 gaactttatc tactaaatct aaacgattag cgtttgaaaa ttcctggagg gagtctttac 2204941 gttgcttaag ttcacgagaa aggacagtga gttcctcatc ctcggtcaaa ctgtctttct 2205001 taagcttaat tgcttcattt tgaagtgaag ccttaaccat tcgaacgaca gtcagtttgt 2205061 ctttctcacg gtttttcata tacagcttca tatcctggtt gagacgctca agaagactca 2205121 taaatccacc ctcttttaga atttgcgttt tctagcagct tcagactttt tcttgcgctt 2205181 tacgctaggt ttttcataaa attcacgctt tcttgcttct tgcaaagtac ctgtctttga 2205241 tacactgcgt ttgaagcgac gaagagcatc ttcaagcgat tcgttttttc taacgaccgt 2205301 ttttgacatt ctctttccct ccctccgaat acaccaatcg actaccttta agttacacat 2205361 ataaacatgt actttgacat tataatataa gccatcagtc aggtcaacta agtgagttca 2205421 cttttccgtc atgagtgcga ctgcctgtct atataatgaa agaaaggggt tggtgaatag 2205481 gatgttaatt ctgattagct ttactgctct tatattattc tttctcgcag gcatgaacat 2205541 gcttcgaaag ggcttaattt caatggcgta ctcaaaaatt gaagaacgtt tgcttttatt 2205601 tacagaccat ccgttaaaag cgtttcttat cagtattgta tttacgggga tacttcagag 2205661 cagctcagcc tttatggtca ttgtcatcgg ctttgtaagt gcgggcgttc tttcttttaa 2205721 gcggacgatc ccgatgattc tggggacaaa tgttggctct acttttacaa ctgaatttat 2205781 tgctatcaaa atggatattg tgatttgggt tcttttaata ggaggtttat tgttttttct 2205841 gactggcagg tatcctttga aacagctggg aacaagcttc cttggactgg gcatcatctt 2205901 cttttgcatc agcggattca gccatcttgc cgggccgctg acaaagctga aaacgggcgc 2205961 cgacgttcta taccatgtta acgattcaaa ctggtccgct ttgctcatcg gcatggtgtt 2206021 aactgccatc attcactcca gttctgtctg tatcggcatt ttgatgagtt ttatgaatga 2206081 agggattatc ggactgacac aggcgatgag cgtcgtactc ggatcaaata tcgggacatg 2206141 cattacagct gtcatggctg ctgtatccgg cggatatgcg gcgaaacaga cagcatatgc 2206201 ccatgtggta tttaacgtgc taggggtggc tctagtattg ccttttctga ccgcagcgac 2206261 cggctttgta gagcagttat cacctgatcc cgcacaaaag atcgcgcatt tcagcctttt 2206321 atttaatgtg gtgacagctc ttttatttct tccgcttaca aacttgtttt accgattgat 2206381 tcaccttctt atcccggcta aataaaaaaa tcggtacatt ttaatgcacc gattttttag 2206441 gttaagaaga caaacgcatg tgttcagtta tttcatcctc aaccacacgg acaaactgtc 2206501 cttcgttgta aggataacct gcttttagga ttttgacttt tacgattttg ccgatcatat 2206561 cttccgtacc tttgaaaaca accttcatat aattgtctgt gtaaccgaca aacatatttt 2206621 cttcttctgt ttccttaaac gcttcctcag ggataatctc aagcacttca ttttcatact 2206681 gagaagcgta ttcttttgca agctggtcag aaagagcaat caggcggtgc acacgttcgt 2206741 ttttcacgtt ttcatccact tggtcttcca ttcgtgcagc tggtgttcct gtacgcttac 2206801 tgtaagggaa aacatgcagc tcagagaatt tatgttcttt aataaagtta taggtttcca 2206861 taaattcttc ttctgtttct ccagggaacc cgacgatgac atcagaagta acagctaagc 2206921 ctggcagtgc ttttttcaat ttatttaaac ggtctgcaaa gaattccatt gtatatttgc 2206981 gtctcatccg tttaagcact gtgtttgatc cggattggat aggaatatgc aaatgattca 2207041 ctatcttatc tgagcggtct aagacctcga tcacttcgtc agtgatttgg ctggcttcga 2207101 ttgaagaaat tctgatccgt ttcacgcctt ccacacgggt gtctaattcg ctcaaaagct 2207161 tcgcgaagtt gtaatctttc atatcttcgc cgtagccgcc tgtatgaata cccgtaagaa 2207221 caatttcctt atatccggca tcgacaagct gctgcgcttg tttaatgact tcttcagggt 2207281 cgcgggagcg gagcaggcct ctcgcccacg gaatgataca gaatgtgcag aaattattgc 2207341 agccctcctg tattttcaat gacgctcttg tgcggtccgt gaaagcaggc acatcaagct 2207401 cttcatatac tcttgctttc atgatgttgc tgacgccatt aatcggctgg cgttcttctc 2207461 ggtattggtc aatgtagcca agcatttttt cacggtcctg tgttccgact acaatgtcga 2207521 caccggggat cgccataatc tcagcaggtg aggtttgcgc gtagcagcct gtgacacaga 2207581 tgacaccgtc aggattttga cgaatggcgc gtctgatcac ttggcggctt tttttatctc 2207641 ccgtatttgt aaccgtacat gtattaatga catatacatc agctgtttgt tcaaagtctc 2207701 ttctttcata gcccgcttct ttgaaaagct gccagattgc ttctgtttca taatggttga 2207761 ctttacagcc aagcgtatgg aaagcaacag ttgccattac tgatcacctc ttaataactc 2207821 tgtttgataa gaaatcgcac tcaacgcgta tagcggagcg gtttctgtcc ttaaaattct 2207881 cggtccaagg ccgcacgtca caccgtcttg ctctgtgagc cgttcaacct ccgcttctgt 2207941 taaaccgcct tcgggaccaa atacgatcaa tagagatgat cctttcggaa ggctgcttac 2208001 aatcgcgctg aatgcgctta tttccccttg cttcgatgac tcctcgtatg caacgacaca 2208061 tttatcgaaa tcctgcatcc tttgaagaag ctgctgaaaa gaatggacat ccatcactcg 2208121 cggcacttcg ttacggtacg attgctcagc cgcttccttc gcaattttcg tccatctttc 2208181 ccgctttttc tttgcctttt tgtcatccag cttgacaaca gaacgcgcgg cttggaaagg 2208241 aataaaggca tgagctccga gctcagtccc cttttggata atccattcaa gcttatctcc 2208301 tttcggaagg ccgctcgcaa tatagacctt tatcggaagc tctctgtttt cattcgtcca 2208361 ttctatcaca aggcaggaca ctttatcttt ggaaacagat tgaagttcac attttgcctc 2208421 gaagccgtct tgagagcagc agataatctg atctccctca ttcattctca tcacgttcac 2208481 aatatgatga acttcttcgc cggtaatcga aaaagtcggc gcttcctcta tttgctgctt 2208541 cgtgagctcg ataaaatatc gttgcatacg ctgtgacacc tactaactgt tattttttcg 2208601 caataatgct gacccaatct tccattgaaa ggatttctac aatggtaaag ccagcttgtt 2208661 ccagtgcttc ttttacttct tgttttttat gaccgatgat tcctgacgta ataaagtgac 2208721 cgccttcttt taacaggctg tacgcttgtg aagtaaagcg aagaatgact tcagccaaaa 2208781 tgttggccac aatcacatca tgttcccctt caatcccgtc taacaaattg ttttgcttca 2208841 cttgagcaat atcgctgact ttgttcagct tgagattgag gcgtgcactt tctacagcca 2208901 cgggatcaag atcgtaggca tgaaccgatt cagcctcaag cattgcagcc gcaatactta 2208961 aaattcccga accagtgccg acatcaatca ccttatcacc cttttgcaca aagcgttcaa 2209021 gcgcctgaat gcagagtacg gttgtcggat gtgtccctgt gccgaaagcc attcccgggt 2209081 ccatttcaat aatcagttca tcagtatgga ccggcgtata ttcctcccac gtcggcacaa 2209141 ttgtaaactt ttcagaaatt ttcacaggat gataatactt tttccaggca gtcgcccact 2209201 cttcttcatt tacttcagaa atagtgatgt ggtttctgcc caaatcaata ttgtaaagaa 2209261 ggagattatt aatcgtttct ttgatgccgt ctacagtttc gcccagaaaa ctgttaaccg 2209321 gcagatatgc tttgacaatg acaccctcat ctgggtaatc attggggtcg agctggtaga 2209381 tttccccgta cacattctca cgttctttaa ttaaatcaag cgggtcctct atcacaaccc 2209441 cacttgcacc agcttcatgc aatatatttg agataggttc gaccgcttca tgtgttgtgt 2209501 gaatgcttaa ttcggaccat ttcaaaacta ccaactcctc atccaataat taatcgcctt 2209561 taaacgcgcg ttttaccttg tcaaagaaac tcatttcctg ttcgtcaggc aggtttccgc 2209621 tgacttcggc aaattcgcgg ataatgtctt tttgtttatc agtcagattt gtcggcgtaa 2209681 cgacgcggac gacgatatgc tggtcaccct gtccatagcc tctgacattt tgaacgcctt 2209741 tgcctcttaa tctgaatttc gttcctgttt gtgtaccggc cggaattttc aatttcactt 2209801 ttccatgcag cgtcggcact tctacctcat ctccaagagc agcctgagca aacgttaacg 2209861 gcatttcaca gtaaatatca tcgccgtcac gctcgaagaa ctcgtgtgcg cgtacatgga 2209921 acacgacaaa taaatccccg gcagggccgc cgtttattcc tggttcaccc tgtcccgaga 2209981 gacgaagctg ctgcccgtca tctacaccgg ctggaattgt cacattgatt ttcttgcgtt 2210041 ttttgatttt tcctttgccg ccgcagtccg cacatttgtt tttaatgatt ttgcctgtac 2210101 cttcacagtg gtggcagacc cgtctgttaa cgacttttcc aaacggtgta ttttgctcca 2210161 cgtttaactg gccggagcct ccgcagtggg agcatgtttc tggatttgtt ccaggtttcg 2210221 cacctgagcc tttacatgtt tcgcacgttt cctcgcgggg aatttcgatg gttgtttctt 2210281 taccgaaagc cgcatcctca aacgacaggg tcatcgtata ctgtaaatca gcaccctggc 2210341 gcggagcgtt tggatctctt cgtcttgtgc ctccgccgaa tatacttgag aaaatatcat 2210401 cgaaaccaaa accgccgaaa tcgccgccgc caaaacctcc gccgccgaag ccttggttag 2210461 ggtcagtgtg accaaattga tcgtaatgcg cacgtttttg gtcatctgac agcgtttcgt 2210521 atgcttcttt tacctcttta aatttttcat ctgatccggc ttctttgtta atatcaggat 2210581 gatatttttt tgacagcttc cgataagctt ttttaatttc atcctttgaa gcgctcttac 2210641 ttactcccag cacttcatag taatcacgct tactcatctc gcttcactct cccgaatttc 2210701 tcacataaat tagattgtat cattttgaat tatgattttt caattccttt tatcccgggc 2210761 aagaaaaaaa gtcaaagcca agagatgcct gactttgact ttctaatcat tgaatcagat 2210821 tatgaaatgt gttcttttcg gtcagctccg gaagcggggc tgacactaaa aagaacttat 2210881 tttttgtttt ggtcgtcgtt tacttcttcg tattcagcgt cgacaacgtt gtcatccgct 2210941 ttgccttcag cgtttgctcc gccttgagct tgctgtgctt tagcagcttc ttcataaagc 2211001 ttcatagaaa gctcttgaac gattgtttga agctcatctt ttttcgcttt gatctcttca 2211061 aattcgtttt tctcaatcgc tgcttttaaa gcgtctttgg catcgttggc ttttttcact 2211121 tgttcttcgt ccactttgcc ttcaagatct tttaatgttt tctcagtttg gaaaacaagc 2211181 tgatctgctt cgttgcggac ttcgatttct tcttttttct tcgcatcagc gtcagcattt 2211241 tcttccgctt cttttaccat gcgttcgatc tcttcatctg agagacctga agaagatttg 2211301 attgtaatgt tttgttcttt tcctgtgcct aagtcttttg ctcttacgtt tacgataccg 2211361 tttttgtcaa tatcgaaaga aacttcgatt tgaggcacgc cgcgcggtgc tggcgggata 2211421 tcagtaagct ggaagcggcc gagtgttttg ttgtcggcag acattgggcg ctcaccttga 2211481 agaacatgga tatcaacagc tgtttggtta tcagcagcag ttgagaacac ttgagatttg 2211541 cttgttggga tcgtcgtgtt gcggtcgatc agttttgtaa acacaccgcc cattgtttcg 2211601 ataccgagag aaagcggtgt aacgtcaaga agaacaacat cttttacgtc acctgtgata 2211661 acgccgccct gaatcgcagc accaagcgct acaacttcat ccgggtttac gcctttatgc 2211721 gcttcttttc cagtttcttt tttgattgct tcttgtacgg cagggatacg agttgatccg 2211781 ccgacaagga tgactttgtc gatttcgctt gcagaaagtc ctgcatcttg aagcgcttga 2211841 cggacaggac ccattgtgcg ctctactaaa tgagaagaaa gctcttcgaa tttagcgcga 2211901 gttaatgtaa gttcaaggtg aagcggtcct gcttctccag ctgtgataaa cggtaaagaa 2211961 atttgcgtag aagatacgcc ggaaagatct tttttcgctt tttcagctgc gtctttcaaa 2212021 cgctgaagcg ccattttgtc ttttgacaaa tcaatgccgt tttctttttt gaattcagac 2212081 accagatgat cgatgataac ttggtcaaaa tcgtccccac ccagacggtt gtcgccggca 2212141 gttgaacgaa cttcgaatac accgtcgcca agctcaagga tggaaacgtc gaatgtaccg 2212201 ccgccaaggt cgtatactag gatcgtttga tcttcatctg ttttatcaag tccgtatgca 2212261 agcgctgctg cagtcggctc gttgatgata cgttctactt caagacctgc aattttacca 2212321 gcgtcttttg ttgcttgacg ctcagcatcg ttaaagtatg caggaactgt gataactgct 2212381 tttgatactg tttcgccaag atagctttca gcgtatgatt taaggtgttg aaggatgata 2212441 gcagacactt cttgtggagt gtaatccttt ccttcaattt caactttata atcagtaccc 2212501 atatgacgtt tgatagacat aattgtgtta gggtttgtaa tagattggcg tttagccact 2212561 tcccctactt gacgttcgcc gtttttaaat gcaacaactg atggcgttgt gcggtttcct 2212621 tcagcgttag caataacttt aggctcgccg ccttcaagca ctgccacaca tgagtttgtt 2212681 gttcctaagt cgattccgat aactttactc acttgaataa cctcctgcta tgtaattatt 2212741 gattcacttt gaccatggaa gggcgaatga cgcgatcctt cagcttatag cctttttgca 2212801 tttcctcaac aacaatgttg gagccgtagt tttcgtcttc agcctgcata acagcttggt 2212861 gcagattagg atcaaattcc tgccctacag cttcgatggc ttcgacgcct tcttttttca 2212921 aggcttctac gagctgacgg tggaccattt ccattccctg gagcaaactt ttcgtctgtt 2212981 cattgtcggc ttcaacctga agcgctcgtt caaaactgtc aagagccggc agcaaatcag 2213041 tcacgatatt ttgagaacgg tatttttggg acgcttccat ctctaaacgg ctgcgtcgtt 2213101 tatagttttc aaagtctgct tgaacacgca aaagtttgtt ttctttttcc tcaagcaaac 2213161 cttgcaattc gttaatttgg ttttgaagaa gttcgctttc atttgtttct tcctgctgtt 2213221 catcagcggc agcttgttct tcaatgattt cttgctcttc tgtttcgttt tgttcaacgg 2213281 tttgtttttc ttctgacatt gtgttcacct ccctcaaagt gtaaggagaa ggacaggtgc 2213341 tgcccttcga taaaatttgc caaaattccc ttattcatca tacagacttg ttaatgcttt 2213401 tgacaagtcc gaagtcacat gctgaagcag gctgacaacc ctggaataat tcatgcgggt 2213461 cgggccgata atcgcaattg agccgatctg cttctggtct acggaataag aagccgtaat 2213521 cagactgcaa ttttccatct cttcatagtc gttttctttt ccgattttaa tcgaaattcc 2213581 cgtgtgcggg gattgaacca gctttaaaac atcctgttct ttctcaatta atgaaagcag 2213641 cgaccgaact cgggtgatat catggaactc aggctggttc agcatattga ttttcccgcc 2213701 aaaaaacaac ttttcaacgt gatttgtgga atgaaaggtt gaacgaagcg cgtcgagtat 2213761 attgtcatag tttttaatgt gctgtcttag gtacatgaca acttctttaa atatgcgctc 2213821 attcagttca tccattggaa cgccgcttaa acggtcgttc agtatattta ccagtttttc 2213881 aatatcagac agatccattt tggtcggaaa gttaatcgtt ttgttttcca catgccccgt 2213941 attggtaacg agaatcgcta ccgccatatc aggctgaatc ggaatgattt gaatctgttt 2214001 aaggtaattc tcactcaact tcggcccgag tacgatggat gtgtaattcg tcagatcgga 2214061 caaaatttgc gctgattttt gaactgtctt ctccagctcg aaaattttct ctttgaagat 2214121 cgagtggatt tggtccaggt cgcttttcgt caatttgacg ggtgacagca aatggtcaac 2214181 atagtaccga tacccttttt ctgacggaac acgtcctgag gatgaatggg ttttttcaat 2214241 aaagcccaat tcctccaagt cagccatctc gtttcttatt gttgcagagc taaatgtgat 2214301 ttcatctttt ttcgaaagag ttcttgatcc caccggctgt gccgatttaa taaaatcgtt 2214361 gattataacc tgaaggatca gcagctgacg atttgttaac atcatcatca cctctgttag 2214421 cactctcaat aagcgagtgc taattctata acaaaagtat caaaccacaa gaaaaatgtc 2214481 aattataact cacccaaaaa agcgccaaaa acttcattgc ctaataattt cccttgatga 2214541 gtcaaataaa cggcagactc cgaattgtga atcagccctt tttcagcgag gtcttttaac 2214601 acgcttggga aaagtccatc cagggaacgg ccgtattttt ctgcgaatcg ttttttgctg 2214661 acaccggctg tttttctcaa acctaaaaac atttcttcct caatctgttc ttctgttgtc 2214721 acttcatgtg tatctctgta cggaaaaccc ttttcagcta tcaggtcaat gtaatgctta 2214781 acaggtccga cgttcactgt tcgtgtgccg ccaatatatc cgtgagcgcc agctccgaaa 2214841 ccgaaatatt gttcgttgct ccaatacgtt agattgtgct tagattccat gcctgcctta 2214901 gcaaagttgc tgatttcata ttgatgaatg ccgtgagctt ccatcttgct catcactatt 2214961 tcatacattt cagcttcctg ctcctgcggc ggaagatgaa gccgcccttt ttgcatcaaa 2215021 ttataaaata ccgttttcgg ttctacaata agggagtaaa cggaataatg ctcagcgtcc 2215081 aatgataaag cagtgtttat ggaatgttcc agatgcttga gggtttgccc cggaagcccg 2215141 aacatgagat caagactgat attctcaaaa ccgatttccc gcgctctttc aaaagaggtg 2215201 aatacatctt tttgcttgtg cactcggccg attttttcta acagatcgtc ttcgaacgtt 2215261 tgcacaccaa agctaaggcg atttacgcct gcttctttta atatttttaa tttctctgcg 2215321 gacaaatcgt ccggattcgc ttcaaccgca aattccgata agtcgcttga gggctttagc 2215381 acgcggttga tcatatccat cagcttttta agctgttcct cagacaggga ggtcggcgtg 2215441 cctcctccga taaagattgt tttgagatca ggctgcccgg tttttgctat tgtatttatc 2215501 atttcctgtt cgagtgcgtt taaatactcg tcgactggct gactttgaat aaaatattta 2215561 ttgaaatcgc agtagtggca aatatgctca caaaatggga tatggatata agctgatttc 2215621 aacggattca ccttctttac agaaagaagc cgcagtacaa gactgcggcg gcttctattg 2215681 ttttttcgga ctgtcgtcca ttttcagaac tgccataaat gcttcttgcg gcacttcaac 2215741 tgagccgacc tgcttcatac ggcgctttcc ttctttttgt ttttcaagaa gtttccgttt 2215801 acgcgagatg tcccctccgt aacatttagc caatacgttt ttacgcattg cttttatggt 2215861 ggagcgggcc acgattttct ggccgattgc ggcttgtacc ggaacttcaa actgctggcg 2215921 cggaatgagt tctttcagtt tttcaacgat cacttttccc cgttcatatg cgtaatcacg 2215981 atgcacgata aaggaaaggg catcgatttt ttcaccattc agcataatgt ccattttcac 2216041 aagcttggac ggtttgtagc cgatcagttc ataatcaaag gacgcatagc ctttagtgct 2216101 tgatttcagc tgatcaaaaa actcatatac gatttccgct aatggcatat cataaatgat 2216161 gctgacacgg tttgcgtcta aatactgcat atcaatgaaa ttgccgcgtt ttccttggca 2216221 aagctccatt acagcgccga catagtcatt cggcaccatc atcgtcgctt ttacgtatgg 2216281 ctcctcaacc ctttcgatct tttgaggatc cggcatgttg gacgggttgt cgacaacgac 2216341 cttttcgccg tctgtcatat acacgtcata gataacgctt ggcgctgtcg taatcaggtc 2216401 gatgttgaac tcacgctcaa ttcgctcctg aatgatctcc atgtgaagca tgcctaaaaa 2216461 tccgcagcgg aacccgaatc caagcgcttg cgaagtttcc gcttcatatt gaagggagga 2216521 atcattcagc tcaagctttt caagagcttc ccttaaatca ttatacttcg ctgtatcaat 2216581 cggatacaaa ccacagtaca ccatcgggtt tagcttgcgg tatcccggca gcgcttcttc 2216641 tgcaggattg gcagcgctcg ttattgtatc accgacacgt gtgtcaccaa catttttgat 2216701 tgaggcagtc aggaagccta catcaccgac cgtcagttca tttgtcggag ttgctttcgg 2216761 cgtgaacacg cccacctctg ttacttcgaa ttctttgccg gttgccatca ttttgatttt 2216821 ttgtcccggc tttaccgttc cttcaacgac tctgatataa gccacgacac cgcggtaggc 2216881 gtcataaagc gagtcgaaga tcagcgcttt gagcggcgcc tccggatctc cggtcggagc 2216941 tggcaccttt tctacgattt gttctaaaat ctcctcaatc ccgataccgg cttttgctga 2217001 agcaagcacg gcttctgatg cgtcaaggcc gataacgtct tctacctctt ggcgcacacg 2217061 ttcgggctcg gcgctcggaa ggtcgatttt attgatgacc ggaaggattt caagatcgtt 2217121 gtcaagcgct aagtagacat tggcgagcgt ctgcgcttca atcccctggg ctgcatccac 2217181 gacaagaatc gctccctcgc aggcagcaag gcttcgggat acttcatacg tgaagtcgac 2217241 gtgtcccggc gtatcgatta gatgaaagat atattcttct ccgtcttttg ctttatattt 2217301 aagctgaaca gagtttaatt taatggttat gccccgctca cgttcaagat ccatagaatc 2217361 gagcaattgt tctttcattt ctcgttgagt gattgccgac gttttttcta aaatacgatc 2217421 cgctaaggtc gattttccgt ggtcaatatg ggcaatgata gagaaattcc gtattctcga 2217481 ttgcctctct aaacgctttt ctttatctgt cacaatctat cactcctact attaaacgca 2217541 aaatacacta gcttagatta tatcaatagg attgtaaaga ttcaatgtaa aacaagaaag 2217601 agaaaagttc cctatcatat ctgggttgct tttctctttc acgtacttat tgattcatat 2217661 cccgtatcca ttcatacatt gactgggcag tattggttac ggtgtccgaa agcgcttttc 2217721 cggcttttga aaacatattg aatgtctcca ccttttccag ctctttttgt ttttctacta 2217781 aatcttttgc cgtgactgtt tctcctagga ttgaggcttc tttttcatta tcttttccgt 2217841 cggtgagcgt aaacgccccc ttcagtgaag ggtcatgata gcctttcata ctcagcatcc 2217901 cgtggtttgc ctgctgcatg ccgaacagaa cgcctaaaaa catgatcgtg acaagcagta 2217961 agcactttcc aaagtatgca atcaaatcaa ccacctattt cttattgttt tttcgtctcc 2218021 ccgctcgctg cgttgacctt ttcagcatcc cagtacattt cgctgaatac gtccgcggcc 2218081 gcgttagccg cacgctgcag ctcttcgaga ttattatcca ctccgccaaa ctcgagcaaa 2218141 agcgctctat cggttaaatc ctgattgtaa acaccattat cgcctggcga gcctttggaa 2218201 aagacacctg tgctaagtcc ggggtatttt ttctccatca gtttatgaag ctcactcgca 2218261 attttatagt tttcttcgaa gtttttgctt tttttcccga cgacaaaggc taccctggca 2218321 tagcttttcc ctttaatcgt tgcggttgtg tcttttttgc gccgagagtc tctgtggatg 2218381 tcaatgatat attgcagatt tttgtttgaa gcgagggcgt ctttcacgac cggccttgat 2218441 tcatcatagg acctggcata gtttaagcct tttttattca attttgactg tatatcggtt 2218501 ttattcactg tggctccgat tccctgggat tcaagcgctt gtccgaacat atctcctaca 2218561 agcgtgacat tggctttaga atggcgcgcc atgtcaggat cggtctcgcc ttttaataga 2218621 gggagatatg attccgtatt gtgcgtgtga tagataaaca cgaccttttt atcacctgtt 2218681 gtttgtttcg gcggatcttt ttgcgcatta tctgattgcg tttgctgttt ttcaatctct 2218741 gccaaattcg cttctctttc ttcctccatc accttagacg gcggcggcga ttccgcaggc 2218801 atattcgtat aatccgttcc ttgtccagct aacaaaatct cggtatcaaa ttgtgcaaat 2218861 cctggcagct cccgaccgag aaagctccgc ggatcttcga ggttaatgct cgtcgccagc 2218921 tttaaagaaa gacgagaaag atgaaatgag ctgtctgttt gagagaggtc agaagcgaaa 2218981 taatggtttt ccatctgcag caaatgtgca aatacgtcac ccggcaattc ttcagcaatc 2219041 ccataaaaag agtcagacga cggcctaagt tccggccgga gagacgtcag cacaccggat 2219101 agaacaaaaa tcacgataag gcttacgata aatagaaaga tggcttttac cgctttccct 2219161 ccatttaccg caacaacaat ctgtctgttt ctgcgtttat ttctcattga atccctccag 2219221 cgcttgtcta gtaattactc tatgaacaag ctagaggaag tagaactgtt tagtgattgt 2219281 aggagccttt gttttcttgt gacacttttt catgaagcgc tgtgtttaat ccgttcgcta 2219341 aaacatttgc catatcgtcg ataaatgaat cgacttcctt cggtgtaacc attaagttgt 2219401 gccctaaagg cgaaagcacc tcgtgaatga gctgccgttt ttcatcttct tgaagggttc 2219461 cgacaatacc taggaacgat tggcgctgct tttgatcggg aagatcgtct tcagtgagca 2219521 ctttcttttt cccaaacgtc atgcctgccg gaacaagcga tcttgatggc ctgttatcct 2219581 tcatttctct gccaaaatgt tttaatatgt agtccaccgt gtcgctggca attgtcacgg 2219641 catcaactac tgtcggaaca ccgatagcaa tcaccggaac accaagcgtg tctttgctta 2219701 aatcttttcg tttattcccc actccagacc ccgggtgaat gcctgtatcc gatatttgaa 2219761 tggttgtgtt gaccctttcc accgcccgcg ccgccaacgc atcaatggcg atgacaaaat 2219821 caggcttcga ttgctcaatc acacctttaa taatgtcact tgtttcgatt cctgttatcc 2219881 ccattacacc cggtgcaaaa gcactgacag gcctgtaacc ctcctgtacg ttttccggct 2219941 gaagcttaaa caagtgcctt gttaccaaca gattttctac tgccatcggt ccaagcgcat 2220001 caggtgtcac gttccagttg ccgagcccaa cgatcaaaca gctcgcatct tttgagatat 2220061 taaggttttc aagaaaagct gagaattcct ccgcaaagac agcagagacc ttctcctgca 2220121 tttccgaatc attctccctg attccctgtg cttcaagcgt taaatagcgc ccttcttttt 2220181 ttcccgaaag ctctgcgcct tcctttgtaa catcaactgt gcggatttta atgccgccgt 2220241 gatcacgctc tttttcaata aagcctttaa tttcttttgt cggcacagcc tgctgattgg 2220301 ccattgcttc cttcgtttcc actgccaaat cggtccgtat caaatactga ttcacatcca 2220361 gctcactctt tttcatacag gggcctcctt cacattaagt acctatattg ttgccatttg 2220421 ctgaataaat catgctaaaa agagaacctt caatgaaaaa tactttacat ttatattgca 2220481 atctaaaggt gtgtttgata gaatacaatt tgttctattg tgaagaagat ttaaccttaa 2220541 gacactgtgc tacaggttgt atcttaggag gtgaaacaca tgccaaacat taaatcagcg 2220601 attaaacgta caaaaacaaa caacgaacgc cgcgttcata acgcgacaat caaatctgct 2220661 atgcgtactg caatcaaaca agttgaagct tctgttgcca acaacgaagc tgacaaagcg 2220721 aaaactgctc ttactgaagc agctaaacgt attgataaag cagtgaaaac aggtcttgta 2220781 cacaaaaata ccgcagctcg atacaaatca agactagcga aaaaagtgaa cggactttct 2220841 gcataatata aaaacgatcc tcaataatgg ggatcgtttt tttcatttct ttttaacagc 2220901 tgtaaaagga acagttcgag caggagctgc ttgtcctttt tcccggtttt catctcatag 2220961 tccatgacgg caagctgttc aataattaaa cggagctcct cctctgaaaa aagccttgct 2221021 tgatccatcg ccagctttac ccgaaatggg tgaactttta gattagaagc gatttgtttt 2221081 tgtccgtatc cctgttccgc gaagtacttc gtctgcagaa tcagccggaa ctgattcgaa 2221141 ataagcgcca taattttgat cggttcttca ttttgtttta gcaaatcata aaaaatttgc 2221201 agactctctg ttcgttttcg gttgacgatt ttattgatca gctcaaaaat attttgttca 2221261 aggcttctag caacaagcat ttttacatca tccagcgtaa tttcttcacg atctccaata 2221321 aacgtgcaga gcttttgaat ctcctgaaaa atcgatgaca gatgaccgtt cacaagcaga 2221381 accaaatgct ccgccgcttc cgtgccgatt gttttctgct ctgtttttgc aaggttgaca 2221441 gtaaagtctg tcgtttcctt tgcatttaat tccttcgcct ccatcataaa cgcgtgcttc 2221501 tttaacgctt tcgtcagctt ttttcgctca tcaagctttt catacggagc aagcaggaca 2221561 aagactgtgt aaggcgcagg tgattgtata tatgattcaa gcgcactgac gttgtgctca 2221621 attttttctt ttttcttttc acctgttaaa aaatatggat ttttcacaat gacaagacgc 2221681 cgctccccca taaacggaaa cgtttcagca tctgcaatcg cttgatccag cgggtcctct 2221741 tccagatcaa aaacggacag attgaaatcc tttgtctcct gatcaacgac cgtctgtctg 2221801 atcctgctga cggtttcttg cagcagatat gtctcttttc cgtataaaca ataaaccgga 2221861 tggacctctc cttttttcag gcttttccac acatcaaata ccattgttgt acgacttcct 2221921 ctctttcatc atccccttct atcctaaatt gagtttgcaa aatagtaaag aggaagcctg 2221981 actgctgctt ccccatttat attaaacgcc tgttcgcaag cccccgggac agcttgtaaa 2222041 aaggcgataa tcaccagaac agaaaacgtt accttagctt ctagattttt caaaacaatt 2222101 ccattatact taagtcagtc aggagggata aagttgaatg attttgaaaa aaacgttcaa 2222161 agcaaacgaa atgatgctgt agattcagct gttggttttg ttgtgtcctt cggatttttc 2222221 gccttcttgt ttgtcatggc aacggttatt cacctagttg gttcataaca gcgactgccc 2222281 gggctgctga tttctcggca gtctttttta gttcgtctct gttatatctg atgtatcata 2222341 tggaggatag acagaaaagg ttccaactct gtttttgtat ctatattgga tcgttccgtt 2222401 ttgatctgtt cgcagcacgc ggatagaatg tctctgtaat agttgcagaa ctttttgatg 2222461 aggatgatgg taccgattgt ttttcccggc tgagataatg gccgttttcg gctgaagctg 2222521 ttggatgaat tcttcaccgg tagagccttt gctcccatgg tgccccacct ttaacacatc 2222581 tgcttttata ttcggaaaca cgttcatcac ctcttgttcc ccttctttct ccagatcacc 2222641 cgtcaagatc cagctcatac cgcccgtctc catccacaga acgagagatg aattattttt 2222701 gcttgccgga tcaggtgctt ccggtgacag tacatggaac tgcaaatcct ttatttgcaa 2222761 cacatcgcct cgcttcacct cttcaattgc cactccctct tccctggctg cctgcagcac 2222821 tttctcatct ttaggttcag aaacgaaccc tttcggaatc acgaggcgct ttactttatg 2222881 atgcttcagc agaatctccg cctctccgat atgatcttgg tcagcgtgcg tcagaattaa 2222941 agcgtcaagc tgcttgattc ccttagcagt taaaaacgga atcagcacct tttcccccag 2223001 tgaaaacgga tgctgttttt cgcgccaagg ctctgacgag taagacaaag tgccgccggt 2223061 atcaattaag acacgacccc gctgatgcgg agcacctaca aacatgctgt caccctgtcc 2223121 aatatctatc atatccactt ctccttcgga actaagacac ggatatataa agagcagaaa 2223181 catcaccgtg cagcaaatgc ctccggttac catcaactgc gacaaggagc gtttttcaat 2223241 cgccataagc aataggatga tcgtgactgt gaataaaaaa agcaaaacag gtgcaggatg 2223301 tgcgatcata atcgtgaaca catcaacatc tgcaatgttt gtgattaacc tattgatcca 2223361 gcttatcaat aaatcaaacc agctgaaaaa caatctccca aacgaagcgg aaagacttaa 2223421 tagaagaaca cctgctacag ctcccggcaa aatacagaag gtataaaatg gtaccatcaa 2223481 catattcatc ggtacgctga tgatagaaaa ctgatgaaaa tgatatagga gaatcggaag 2223541 cgagcccagc tgagcgatga gtgatacaat tgtcagctgc cccaaggagg ttttaacctg 2223601 ctgaaaaata gaagaggata gaattaaaga aaaactgacg gcgaacgata gctgaaaacc 2223661 ggcttcaaag agatgataag gattgaagag cagaaggacg atgtacgaaa ggcaaattgc 2223721 agttgcagag cggacacgcc atttgacaag acttccagct aagtaaacac ccgacatgag 2223781 agcggcgcgt agcactgaag gagcagcgcc ggtcaacatc acatagagcg gcagaaataa 2223841 cagcaacaga attgacgcct tttctctagt tataccaagg cggatcatga tataaaacaa 2223901 acctgctgtc aaaatcccca cgtggagtcc tgatattgcc aagagatgga caacaccaag 2223961 cttttgatac gcggtaagca cttcatcctc cacgtaaaat ctgtcaccaa ctgtaagtgc 2224021 ctgtacaatc cctgtcgaat caggaggcag aaggctgttt gtgaatgata tgatatgttt 2224081 tctcaagctg agcaccttgt acttgaaatt ttcaggttcg ctgcagtttt ggatagacgt 2224141 gacagagtag ttccaatgaa tatgctgccg ataaagatac tcgttataat caaatgcacc 2224201 cggcacagtt gcgtgattcg gttcttccaa tgtaccagtc aactcacatg acattcctgg 2224261 ttctatgtat aacagctgtt ctttttcacc agcagactga atgcgatacg cagcagccca 2224321 tttttcctta tcaggtgtct caaccatcat agacatacgg tcgccgtcaa ttttgggaat 2224381 agtgtcaatc actgccttga attgataggt tccctgccga taggaagaga cattctgaga 2224441 atctgtgact gcatacagta caaaaaacaa tataaaagag aagaaacaaa caataataag 2224501 aaaagcgtgc ctcgttttga ttaaaatgat gaggagaaag aggatgaaaa gaaaaatagc 2224561 ggggaaataa gcggcggcag taattccagc cgttgccgaa gctgccgcca taggcaataa 2224621 taagcgcgaa ttacgcattc atcacacgta gctcgtgaaa agtgtattcg cctgttcatg 2224681 tatctttttc aattcttcct ccgctaaacc ggcatcagcc aatttcccta ttagacccgc 2224741 tacaaatgaa agcttttctc tgtttttcag atcaacgatc atttcatcga gttcaacctg 2224801 ttcaacagtt acacccgcct gttcaaataa ttcctgcgca tacggatgtg ttttgtaatc 2224861 ctcagcataa taaaccgttt tgataccagc ttgaataata gatttgcagc attgaatgca 2224921 cggataatgc gtcacataaa tctcggctcc atcagtcggc accccaaact tagagcattg 2224981 aagaatcgca ttcatttcag cgtgaatggt tcttgcgcaa tgatcatcta tcattaagca 2225041 tccttcatct gcacaatgta cgccgcccgc gattgaccca ttgtagcctc ctgctatcat 2225101 gcgtttgtct ctgactatag tagcgccgac agataatctc ggacatgtgc tgcgcagcgc 2225161 caataaatgg ctttgagcca taaagtattg attccatgaa attcgttcca cgttgttccc 2225221 tccaaatgtt gtgttgcctg acctttagtt tacctatcat aatgcatgac cgtcaaatca 2225281 ctttactgta atggaagact ttattttctc aaatgacttt tcacctattc ctgaaacctt 2225341 agtgatatct tcaattgttt ggaaacgacc gttttcctcc cggtatgcaa taatagcttc 2225401 agctttggat ggccccaccc ctgagatgcc ttgtaactcc tctaaggttg ctgtattgat 2225461 attcaccagc gctcccttcc ctccatcgct ttggacagac cctccgccac cttgctgcac 2225521 tgctgtttcc tctccctttt tcgggatgta caccactgtc ccgtcctgca gaatctccgc 2225581 caaatttact tgcgcttcgt ctgcttgttc actggtcccg cccgctttct caattgcctg 2225641 agatactctg tcccctgttc gcatttcata aacgccagga tgctgaacag cacctttgat 2225701 gtctatcaca attgtttcgt ttgactcgtc gttgtttgct tcctgcttta ccactgtatt 2225761 ttctgtctct gttggtacag cttgcttcac cggctcttta tttttccctg tggccagaaa 2225821 gatcataatc gctgtgaaaa cagccgcaga agccgctaaa ataattgctt tcttatgctg 2225881 attcaaccaa ttcatcgtgc atgttccccg ctttcgtcat attttatttt cataacacat 2225941 atggtttaga ggataatagc tcaaaggagg ggaaaccatt gaagataggc tttatcggca 2226001 caggaaatat gggtacgatc cttatcgaat catttattga atcaaaagcg gccgatccct 2226061 caaacatgac aatcacaaac cgcacaattg aaaaagcgtt gcacataaaa aaccgctaca 2226121 acagcataaa cgttaccgaa agtctcgaaa agctcgtttc tgaaaacgag atgattttta 2226181 tttgtgttaa gccgcttgat atatatcctt tactggcaag agcgttacct tatttaagaa 2226241 aagatcatat tctcatttca attacaagcc ccgttcaaac cgaacagctc gaacaatatg 2226301 tgccgtgtca agtggcgcga gtgatcccaa gtattacgaa cagagcgctg gcaggtgttt 2226361 ctctcgtcac tttcggcaca agctgcggcg aatctgcaaa agcgaaaatc aatgagctga 2226421 tgcagcatat ctctcatccg ctgcaaattg aaagtgacat cacgagggtt gcatcagaca 2226481 tcgtaagctg cggccccgct tttatgagct atctgattca gcggtttata gatgcagctg 2226541 tttcggaaac atcagtgtct aaacaggacg cgattttgat gtgtaaggaa atgcttgtcg 2226601 gaatgggaaa actgttagaa accgaattgt ataccctgcc tgcattacag gaaaaggttt 2226661 gcgttaaagg cggtgtaaca ggagaaggca ttaaagcgct ggaaagcggt gtgcaggata 2226721 tgtttcaccg ggtatttcaa aatactcata tgaagtacga ggaggatatt tccgcagtga 2226781 aaaagcagtt tcatgtgtag acgagtatgt catacgttcg tctgtactgc aaaagcataa 2226841 aaaagcattt taaaaaacca tcgttttagg aaacgatggt ttttgatttc tgcgccttga 2226901 aaaagaggcg ttctgattgt gctgatggct cggtatccgt aaaatcagct gtcacgcgat 2226961 ggagctgaaa gccgcagttc ttaagcattt cttcgtattc ttccaccggg aacgttcttt 2227021 gctcgtgtgt ctcatcaaaa cgatcatacg cttctccgtt ccacacaaaa aacgacatat 2227081 catgaatgac agaaagctcg tcacttccgg caaagctctg ccaaatatag ctgatatctt 2227141 cgtcctggtc agcaaatgtg ctatccggaa agacttccgc aattttaaaa gatgaatgaa 2227201 catcaaacag caggatgcct tcaggcttta atacccgaaa aacactttta aaggtttcga 2227261 tcacatcatt ttttgttttt aaataattta atgagtcaca gcatatcaca acagcgtcaa 2227321 attgaccgtc aaagccggta atctctctca tatcctgctg aagaaataaa ataggctggc 2227381 tactcgatac cttttgctgg gcgaaagaaa gcatctcttc gctgagatcg atgcctgtaa 2227441 cctcgaagcc tttttcggca agccggatgg agatttcccc cgtgccgcat gccagatcga 2227501 gaatacggcc tttttccggg agagatgctt caatccattt tgtccattga tcgtaaggcg 2227561 cgtgtgacat tagctcgtca tacacgcttg caaagccttg ataaatcatt gattcattcc 2227621 aaagtcaaga tctgcgagcg gagcgtctcc ccacagcttt tcaaggttgt agtagcttct 2227681 ttcatccttg tggaagacat ggacaactac atcgcctaga tcaacgagaa cccatcttgc 2227741 ttcatcaaag ccttccatct ttttgacttg aatgccgttt tcatcagctt gatccttgat 2227801 ttcacgggca atcgcctgta cctgtttatc tgaatttccg tggcagatca gaaaataatc 2227861 agcaaccaga gaaatacctt ccatatccag tgctaaaata tcctctgccc gtttatcatc 2227921 gcaagccgca gctgcgatct ttaaaatgga cttttggttc attcacaaat tcctcctgtt 2227981 cagctgccag acacaagcca gttatacgtt aaaaatgtgt ctggaaaaac cggttgattt 2228041 tttttcataa gaaaaaccat tgtattttta atggactgaa tcagcgcttg attcaaatct 2228101 gtctcagcaa gcttacgcac ctcatcgaca ccgggaaatg cccggtttgg ctcaatgtaa 2228161 tcggcaacgt aaatgacttt ttctaaaagt gtcatgccgg ggcggcctga ggtatgatac 2228221 ctaatggcgt caagaatgtc ttcatcttga acccctgcct ctctttggac caaataagcg 2228281 ccgaccggag cgtgccagag ctccggatta tgatccaata aatgcgcagg cattttttca 2228341 cgcgcaataa tttgtttcat ttcttctttc gggcggaatt tggcgtaatc atgaaagatt 2228401 gccgctattt ccgctttttt agaatcggct ccaaaacgct ccgcaagttc gatcgccgtg 2228461 ttcatcacgc caaccgtatg gatatatcgg tgttcggtca attgctgctt cacgcatgca 2228521 agtgcctcct cacgattcat ataaaccatt ctcctctaca tacttcttca ctttatcagg 2228581 gattaagtag tcagtgggct tcttgctttt aaaccgttcc cttatcatag ttgatgatac 2228641 ctcaaattcc ggaacgtctg caaagagaag cggataaggg gtttcaacat gaaaaccggg 2228701 gcgctttact ccaataaatt gaatgaggtt cagcagctcg tccagcttat accatttcgg 2228761 caaatattca atcatatcag cgccgataat aaagaacagc tgatcatttg gataacgctg 2228821 cttcagtaaa gaaacggtat caaaggtata tgatggccct tctctttcca tttcaacaag 2228881 ctccagctta aaggacggat tagattgaat tgcaagcttt agcatttcca cgcgatgaaa 2228941 gctgtcggta tagtcttcgt tctgtttatg cggcggaatt tgattaggca taaaccaaat 2229001 ttcatcaagc cccgcctggt acagcacctc attcgccatt aagaggtgac cattatgcgg 2229061 agggtcaaac gtgcctccga aaattccgat tttcttcatt tcaaccacct ttaaggaagc 2229121 tcgatttgtt tattttcctt tgattcctta tataacacaa tcgtattgcc gattgtctgc 2229181 accaattgag agcggcttcc ttttacaaga gcttccgcta catcgttttt atcctcttcg 2229241 caattctgaa gcacgctgac tttaatcagc tctctcgctt caagcgcctc agcaatttgt 2229301 ttaatcatgt tgtcgtttac tccgccttta cctacttgaa aaatcggcgt taaatgatgc 2229361 gcttttgaac gcaaaaaacg tttttgttta cctgttaaca ttctgttcct cctaattttc 2229421 ctattacaat agatctcatt ttttcaatat taggctcttg tccagtccac aattggaaag 2229481 acaatgctgc ctgttcaaca aacatgccca caccatcgag tgttttcaag cctttttggc 2229541 ttgcttcttt taaaagtgcc gtctgtattg gattatacac gatatcacat acgacggcac 2229601 tgctcgcggc acgctgtaat gaaagcggca catcgtccac gttcggatac atgcccacag 2229661 acgttgtatg gatgataaca tcatactgct caagacgttc ttctgcttct tttatgctta 2229721 atacttcttt attgtgaaac gagggagtag cttctgtaag ccgctttgct ttttctaacg 2229781 tccggttgca aatgtcaaat tttttcgggg tatttcggac aattgttgta aaaatggctc 2229841 tcgccgctcc gccagcgccg atcattaaga atgacagttc agagatgggc ttgtctaata 2229901 ccttcattaa tgacttcacg aagccttccc catcggtatt gtatccgaca agcttatctc 2229961 cctctcttct gaccgtgttt acggcaccga gcacttttgc actctcatca atatgatcca 2230021 aataatccat aatggaaacc ttgtgcggaa cagtcacatt gattccttgt acgcctagag 2230081 ctcttattcc ttttaccgca tcctccagat cattctcttc taccttgaag gcatgataat 2230141 gtccgtcaag cccgaggtct ttcaatgatg cgttatgaat atcaggtgac atagaatggc 2230201 caataggatt tccgataacc ccgtacagct ttttcataca cctctcccct tttcttaaat 2230261 taatgaacgc cgaacaaata catgaacgcc ttttggcgcg tatgcagtta cctttttatc 2230321 agcgtcatgg acagtaaccc agcctaaccc agagaaaacg atatctgtct ttttgtcttt 2230381 tatcgtaaac gtatgggcga ccaattcagg aaactcatcc atttcatctt tacccggagg 2230441 tgtgagcaat tcccctgcat gcttttcata aagcgcgtct gcattttcaa gttttgttct 2230501 atgaatcatc agctcattcg gcatatagca aataaaagga gatctttccc cagacacata 2230561 atcaaacctt gcaagtccgc caaaatacag tgtttgctga tcattaagct ggaatgtgcg 2230621 aggcttcagc tcctttttag gagataatat tttcaggtcc tttttattga cataatgcgc 2230681 catttgatgg ttgttgataa ttcccggtgt atcataaagc gatgaaccgt catccagcgg 2230741 gatttcaatc gcatcaaggg ttgtgccagg aaattgggat gttgtaataa tatcttcttc 2230801 acctgacact tctttaataa tccggttaat aaaggttgac tttcctacat ttgtacatcc 2230861 gacaacatag acgtcttttc cgttgcggta atgctcaatc gcgtcaatta cttctctgat 2230921 tccctggccg cgacccgcac tgaccaaaaa tacgtcaacc ggttttaagc caagctcttt 2230981 cgcttcacgc ttcatccatt ggatcagacg ctctcttttc agtgacttag gcaaaatatc 2231041 cgctttattg ccaactaata agatagggtt tccccccacc aagcgctgca gcccattaat 2231101 ccagctgccg ttaaaatcaa aaatatcaac aatttttacg accagagagt ccgtttctcc 2231161 aataccgtga agaatgttca aaaaatcatc atcagttaag gagacatctt gtatttcatt 2231221 atagtttttc agtctgaagc aacgctggca aatcacattt tctttcgtaa gcgatgcagg 2231281 cggcgcgtac cccaaacctg ttttgtcctc ggtttggatc gtaactccgc acccgataca 2231341 aacaaccttt tccatttctt actcctccca ctgaatgtgc ccttttcgtt tgagagcact 2231401 cagtattctg cgttcgacct ggcggttaaa gcgcgtaatg aatccgtcag aggaagcgac 2231461 tggcacgacc aaaatcgtat ggtagccgtt tcggtttccc ccgagtacat cggtcagcag 2231521 ctggtctccg atgacaacgc agtcctcttt tttcagctcc atattgcgca ccgctctatt 2231581 aaaggcttta cccatcggtt ttcttgcttt atagatgaat gggattccaa gcggttctga 2231641 gaaaagtttc actcttcttt cgttattatt agagacaatt gtcactttaa tgccgtgttc 2231701 cttcatttct tcaaaccact cgatcaatcg cggcgtcgcg ttcggcctgt cccattcaac 2231761 aagcgtatta tccaggtcag taataattcc ttttacattt cgttccttta atttctcagg 2231821 tgtaatatga aaaatatttt ttacaaactc gtcaggtaaa aaaaactttt ttaacaaaac 2231881 ccgcaccctt ccctttttct ttctttcaaa atgattgtcg aaaaaaatcg aacttgcgcc 2231941 taaagaaaaa ctgagcaaaa aaatttcgac aaaaattggg tttcttcacc aggtgtggat 2232001 aaatttacac acactatcca ctcttattac atcactcttt agacaaatta taaacacgat 2232061 actcacaagt tatccacttt ttggtgtgga taacagaacg attgttctta tatgcatttc 2232121 atggtagatt aaagataact tcaacctcag atgaatgcaa cttatcattg tatgcgttaa 2232181 aatcatgaat gattccaact tttaaggagg tgcctctccc attaattggg ttcctagcat 2232241 gagaaaactg tctgatgaat tactaataga atcttatttc aaagccaccg aaatgaattt 2232301 aaaccgtgac tttattgagt taattgaaaa cgaaataaaa agaagatcgc tcggacatat 2232361 tatttccgta tcttcttaat aggaatttgt ctattttttc cgggcgtatt tccttttttt 2232421 actcagatga ctgatattat atcactttgg ctgcgcgctt tactactatt ttcagcaaaa 2232481 aacaccccta aaaagaggtg ttttaaaggg ccggttatta tgctaaccag tatatgccgc 2232541 ccacaacaag gagaacaaca actaaaacaa caataaaagc gtatccatat gctctgcctg 2232601 cgccatacat gtgaagcgcc tccttaataa ggttttataa cagcctatgt aggagaaata 2232661 aatcggacta ggcggttgtc cggctcaacg ctgcaggatc tgccccgcga actaatttat 2232721 taatgttcaa caacagaatt tcgtctattg gcaataaaga atccacaaat cattgcaaga 2232781 atggccatcg cccaccagaa cgttgagatc gcctgatcat gatcgatgat aatcaaacga 2232841 atgacagctg tgatgccaat ataaatgaag tagcgaagcg gaaaatgaaa gtctgatttg 2232901 aagtatttga taatcaaagc aatgaactca aagtacatga agaatataag cagttctcca 2232961 agcatctcat aatagctgtc cactttgttg aacagtgact tgtatacgaa tagcacaatg 2233021 taccaagtct cgctgatcag aagtgcgctt aaggctaacg ccagaaagaa cagacagacg 2233081 ttgagaagcg cttgtaacag gtaaggcacc tttttgaatt tgttagaaaa tctcatcatg 2233141 ttgtctccta tttcaatata ttcgtggttt ttattctcag cctacatctt ggtgttccaa 2233201 aatcgtagca caatgtagta cttagaattc ttttgtatac tgtgaaactg tccctgcatg 2233261 cgggacatca ttcgcgcaat gcttctttca ccgagtccgt tgctttccgg tgttatatct 2233321 gcaagtttaa tcgtattgct aacatggatc tcaaatatct cttgatccga tacaaacgtg 2233381 atactgattt tttcttccgg atctgcgtat ttcaataagt ttgacatcac attatcaaat 2233441 acacgaccaa gctcctccaa attcacgtta atataggttt ccggcagctc gcctgaaata 2233501 tggacccgaa aatgctcctg atgaaggata gcaatctgat ctgatattag atcgtagatc 2233561 acttctttca ctgcaacggt ctccagatcg gcctcatatt ccttgttcag caggaaatac 2233621 gcaaacagat tgtcagacaa gctttttaat tgcagtgctt taccataagc attggctaca 2233681 taccgatctt tgctggcacc cgcttcgcct ccctcttttt tggcaaactc cagattcatg 2233741 atcagcgacg tcagcggtgt gcgcatatcg tgcgacattt cggtaaccag gctgcggctc 2233801 tcagcttgca attcctcgat agctttaagt ttatccagga aagctttccg cagatcctca 2233861 atgctctttg caatcatcgc taattcatca tgccctttta tcgtcatctc gtagtccagt 2233921 tcgccccctt caagaatatg aatctcttga tgaatcgttt taaggtagcg aagactttgg 2233981 cgaattccga agagaacaat gattaaaaag atgagggttg ccccgagcaa atccaatgca 2234041 aaggccagat cataatatcg ggaagagtag aaaccgtcga taatgactcg tccttcacca 2234101 tcgctaaact tgacaggatg tgaatgattt tgagcgtact gagtcagctt ttcctttcca 2234161 taatccgatt cggaataaat agaatcatat tgcagctcct gatccttgaa tatggtgagg 2234221 ttaatgtaat tttctttttt gacccactcg ccaaacgctt ttctatctga tgtagacaac 2234281 tcattttctg aaacgtactt gctgaatttt tgaatgtatc ttgctgactc ctcgtgataa 2234341 tactcttccg aactcagata tccctcgatc agatcatctg tgatcttttg caacgtcaga 2234401 aagatcacac cactcacaat cgcagcaacc attatcagca aagccagttt tttggttagc 2234461 gtaaatttaa gatgcgccaa atcgatatcc tcttccccat tcagttttta tataaaccgg 2234521 acgtgccgga tcatcctcaa ttttggagcg cagcttccgt atatgcacca tcaccgtatt 2234581 gttggaacag taaaagtaag gctgtcccca cacactctca tatatatttt gggcagaaaa 2234641 tattttgttg cgtttgttca tcagaagttt caggatacga tactccagat ctgacaactt 2234701 gatttgcttc tcctctttcc acacctcatt aaattcttcg ctcactctta gtttgccccc 2234761 gataagaaat gtttcttcct gttccttctt ttcctgatag atagtatatc tgcgtaattg 2234821 agcaatcact ctagcgtgaa gttcctcttc cgagaatggt ttagtcatat aatcatcgcc 2234881 gccggcgagt aatccctcag ttttatcgag tgtactcgat ctggccgtca gaaacagaat 2234941 cgggacgtta gaggatttcc tgatgtgctg acatgtttca attcccgaaa tgcctggcat 2235001 cataatatcc aaaataacca aatcaagcga gtcattcaca agttgcaatg ctcgctttcc 2235061 atccttggct cttagcacct cgtaacctgc acgtgtaagg gattcctcca aaagatcacc 2235121 aatatcctca tcatcctcta cgactaatat tcgataggcc atgtctctct cacctcatga 2235181 ttcttgttgt tatttctcgt gtgtccttac tatatatcgt tcatagtaat aagtacgtta 2235241 taagatacta cgtaaatctt aacaatttat gaaagctgat gctcgccaca aatttgtcac 2235301 attttctaaa aaaaatgatg actcttcata aattgttaag attcggtctt tatatttatc 2235361 cattgtaagg ctcaagtttt tcagatccgc actacacatt gccgtgataa atgggaaagg 2235421 agtattgata tgattgtaca aaaagaagga cgcgggcaac cggtgagtct gcgggaacgg 2235481 gttcattttc tggacatcgt acgaggattt gccttgcttg gcattattat tgtcaattat 2235541 tttctgatcg tagattcagt aaagggattc gaaatggcct ccgatgacgt actgcataag 2235601 ctggtttcct ggtttgccga agggaaattc gttacgttat tctccttcct gttcggagtc 2235661 gggtttatga tctttatgga tcgagccgcg cagaaggtag agagtcccaa caagctgttt 2235721 gcccgcaggt tatctatcct gttgggattt ggcattttgc acatcacatt tgtttgggtc 2235781 ggtgacatat tggcctttta cgccgtaagt ggcttcctgt tactcgcctt ctataaacgc 2235841 acggccaaaa cggtgcttag atggattatc gcacttatcg tgtttcaatt cctgactcct 2235901 gttttcacaa tgttgtacaa tgtcatcaat actgcagggt caaaaaaccc gaatttttca 2235961 gagtttactt tgtttagcca cagcagcctt acctacatgg aatccatcag cactcggtgg 2236021 acagatatgg tcacgatggc tgccggctct ttctctatga tctattccat gtttctcatg 2236081 tttctgctgg gcgtgtactt tgttaagatg gaatttttca aagacatgga agcgaaaaag 2236141 cctatatgga agcgtatctg gatcattagc acaatcgctt ttctaataac acaaagcagt 2236201 atattactag acatgtttaa tctttctgag aatatgctgt ggaaggacat ttcctctgtc 2236261 ttgggtcaaa atggcggctt aaccggaagt atgttttata tgagcacttt tgcaatgctg 2236321 tttctatacc ttcctcagct gcgaggccct atgatgatat tcaccaaagt cggacggatg 2236381 tcattgacct gttatctgct tcactctatc attggaacag ttctgttcct caggtacgga 2236441 ttcgggcttg cggatcatat tcaatccgcc ggcacgttca tgttcagtct ggccgtgtac 2236501 ttcgttctta tgagctttag tacattgtgg ttgaaacggt ttaggtacgg tccgatggaa 2236561 ttagtatggc gcaagctgac gtacggcaaa gtaaacggga gtcccaaagc aactccgctg 2236621 cattcggaaa aatctattca gaaataaccc ccttgcacag attgcatgac ttcaaattag 2236681 tgttgttgaa tgaagcgggc attaaacgga cagatttgat atatggacta gttattttta 2236741 tatcatttag gcttctttgg gctaataaat ccaccagagt ttactcaatg tgcattgctc 2236801 atgatcgaat ctaaattgaa tcttttacgc atgttcatag tcaaaggcgc ctcattcgac 2236861 tatttttgta acttttcgca ggaaaaattc gagaatgatg acaaatcccg catacgacac 2236921 ttaatacggt agtgaacaat agtaaattag ggttacatgc agcttgtttt ccaatgaaac 2236981 aaagaaaaag aatcatacaa aaagacagga gaaagctttt gaagtatttt aacgccaaat 2237041 ttaccgcgga agaaagagcg atggaatcac ttttttgtga aaaggcctcg cagagcagct 2237101 cgaatgtttt actgaacgac tgaactctat attttagcaa ctgagggagt gaacaatcat 2237161 gaaaactaaa aatgaaccaa aagttattct ggaactagca aaggaatctg atctgccaga 2237221 attccaaaaa aaattacaag aagcctttgc gatcgccgtg attgaaacgt tcggtgattg 2237281 cgaagatggg ccgattccat cggacaatga tgttcaggag tctttcaatg ctcccggagc 2237341 agtggtatat catattcttc aggatggtaa gaatgtcggt ggtgcagtag tacgtatcaa 2237401 cagccaaaca aatcataatt cgctagattt attctatgta tctccagaat atcacagcca 2237461 agggattggt ctttctgctt ggaaagccat tgaagcacag tatccggata ctgtgctttg 2237521 ggaaaccgtg acaccttatt tcgaaaagcg aaatatcaac ttctatgtga ataagtgtgg 2237581 atttcatatc gtagagttct acaatgaaca tcactctaat ccgcatatgc atcgcaatgg 2237641 acgtgaagat gacaagcccc tactgaatga tgatgacttt ttcagatttg taaagattat 2237701 gaaaaaaaag gactaaacaa ttgaacacgg cgagatgccg cagagagttg ctggtaactt 2237761 ttttatattt cattatcaga ggaaggtaat aatgatgttt aaaaggtgtt ttgatccctg 2237821 tctcataaac aggggtcaaa acacctttga atcatcggtt tcttttctga catataccac 2237881 gcccactagt ccctcaacat agtaaaaaca tatcatgagt tacaaaagct tttattcaaa 2237941 gcatatgttt attttattta tacttatttt catcattttt cagaattctg gacacaaatc 2238001 gggtacctat tagaggccaa ggaactctac atttcattaa gaaatacgta ctcattgccc 2238061 tgctttaatt aattttaagc cctcgcacta tgcccccccc tgaattaagt atttgatgta 2238121 actttgaaat taagtttatg aaaatctgtc acaaaccctt atttcataac acatcatttg 2238181 tttcagcttc cctcgcgaat accggattaa tgctcggctt taagatagtc aaccaatctc 2238241 tccgcactgt tcttaacatc ttcttttgaa agatgaagtg tcccatattg tgtaaacgca 2238301 ggaagaaaac gcattcctat atagttagca gtgacttgaa acggtctgat aagctcgctg 2238361 atcgtgatat tatattctcc gcctgcttga taatcagatt cctgtgcgcc taaggagata 2238421 gctaagagta gttcttttcc atgcaattta gttcctccag ttccataagc ccagccatgt 2238481 gttaacacat catcttccca ttgtttgagt aacgcgggac tgctgtacca atacattggg 2238541 aactgaaaaa cgatacgctc atgatctaac aggagctgct gctctttttc tacatcaatg 2238601 ataaaattag ggtattcacc gtacaggtca tgaaccgtaa tgtctttctc ttgctttaaa 2238661 cgattcatcc aggttttgtt gacaacagac gtttccaaat taggatgtat aacgataact 2238721 aatgttttca ttagactgat tatcctttct ttgccaatta gttattattt tttacgataa 2238781 tgaattgatt ctaattttaa aatagcaact ttatttacac ctattttatc ctttttcatg 2238841 aattcagggc aactaattgg gcaccaaaat caatgatgac ttaagacatt gttttgtaga 2238901 aatccgatat acagaataat ccattattta gaaaatttct accttttccc tcaatccgag 2238961 ctcgctcttc atgcggatgg cctattttaa aggaataact gactatgttc atcagttatt 2239021 cctttaaaat acgaaagtct acgatatttc catatcgatc cgcttcaatg tgacagcacc 2239081 cctcaagcag ctgttttaat tttccacgtc cgcgttgtac ccttgatttt gctccggagt 2239141 aagaaatgcc gagcttttca ctcaactctt tttgtgataa cccctggaaa tcagttaact 2239201 cgagcgcctc tcgatacttt tcaggcaacc gtttgatggt cgatcgaata cacacagttg 2239261 cttccttggt gaaattttct tcctctgcac tgtcattaaa atgtagaaca tcaggcaata 2239321 tttcgcttgt tttttttgta cggtaaaaat caataatcgt atttctagtg atccgataaa 2239381 tccagctgtc gatcttttgt tcatcgatca gatttgggag atgcacttgt attttcataa 2239441 atacgatttg caagaggtca tcaacgatag attgatcgtt aaccctatgt gaaatatatg 2239501 tttttaacgg ctgatgaaat tgatcccata gatcctctat attcatttga aaaaacctcc 2239561 tataattttg cgtctgcttt acatttgctt cgtcttttta atcgtaacaa agagcaaaca 2239621 attgttgaat caattgtatt gcagctgttg ccaaaaataa tgataaagga gaggtttgtt 2239681 gtggagtata cctatttagg gagaacagga ttgcgggtga gccgtttatg tttaggcacg 2239741 atgaattttg gagttgatac agacgaaaag actgcgttcc gtatcatgga tgaagcactt 2239801 gataacggca ttcaattttt tgatactgcc aatatttacg gctggggcaa aaacgcagga 2239861 ttgacagaga gcatcattgg aaaatggttt gcacaaggag gacagcgccg cgagaaagtt 2239921 gttctggcga caaaagtata tgaaccgatt tctgatccga atgacggacc aaatgatatg 2239981 aggggcttgt ctctatacaa aatcagacgt catctggaag gatcactgaa gcggcttcag 2240041 acagatcata tcgaattgta ccaaatgcat catatcgata ggcggacacc gtgggatgag 2240101 atatgggaag cttttgagac tcaggttcgc tccggcaaag tagactatat tggatccagt 2240161 aattttgcag gctggcattt agttaaagcg caagctgaag ctgaaaaacg gcgattcatg 2240221 ggactcgtca ctgaacagca taagtatagt ttattagaac gaacagctga aatggaagtg 2240281 ctgccggctg cacgggatct tggtttagga gtagtggcgt ggagtcccct tgcaggaggg 2240341 cttcttggcg ggaaggcatt gaaaagcaat gccggaactc gtacagcaaa aagagcagat 2240401 ttaattgaaa aacatcgttt gcaactcgag aaattttcag atttatgcaa agaactagga 2240461 gaaaaagaag caaatgtggc tttggcatgg gtgctggcaa atccagtttt aactgcgccg 2240521 atcatcggac cacgaacggt tgagcagctg cgtgatacga taaaagccgt tgaaatcagt 2240581 ctggataagg agattctccg catgttaaat gatatctttc ccggacctgg aggagagaca 2240641 cctgaggcat acgcctggtg atacattcat tactcaatac tgacattttt cttaaatatt 2240701 tatactgaac tatcatatta agaaagacaa gagcatgttt gtctcttgtc ttttccacat 2240761 cgtgctgaaa atgctggcta aacatcgaca aaaatgctgc cgcttaaaaa agaaccctaa 2240821 acaatagagt aactggaaag acaactggct tgatcagctt gggacccctt tcagctgtat 2240881 ttaaatcaat caaactaatg attcattggc agtctaaata ttattattgt ttctttacaa 2240941 aatagtaata gcccctgtaa tgattgctaa caacgtaata actaatgatg taattacagc 2241001 ccacttaacg gcaaaccttt gaaatgaccc caagtccatt ttaagcatgc ttactagcaa 2241061 tactgttgac gcaaccaatg gactcatcag atgaaccggc tgccccatta tagaagccct 2241121 tgcaatttct actggttcta taccatatgc tgaggcagct tctgcaaaga taggtaccat 2241181 accaaagtaa tatgcatcat ttgataaaac aaaagtaaac ggaatactag tgagtgctac 2241241 aataacgggg aaaaaccctc ccattgatga ggggatgatg gatattaatg atcctgctat 2241301 ggcatccacc atctttgtcc cggataatat accagcaaat actcctgctg aaaataccaa 2241361 taataccacg gttatggcat taccagaatg ctcggcgatt cgctccttct gcatttttac 2241421 attcggataa tttatagtaa gggcaagaac aaaaccaatt aaaaataaaa ctgacggatg 2241481 cttagttcca agcacaataa acaccatgat acttataacg aggaataaat taagatatat 2241541 taagcgtggc cttttcaatt gttcgctctc caaagtagca gccatataag attgagagct 2241601 gtcctttgtt atatgtctag gctctaattg aacgatgcct attcgattcc tctctttcct 2241661 tcccattaga aaagccagaa atatcacaca agcaatacct ccaagcatgg tcggaagtaa 2241721 tggcacaaag aaatctgaag gatccaaacc cagcactgaa atcgctcttg tagctggtcc 2241781 gccccatgga gtcattccgc taacgatact caacgacagc attgctaatg tcgccataac 2241841 catgggattc ataccaattc ttttatacaa aggtaacatt gctgagactg ttatcatata 2241901 ggttgttgta ccgtccccat ctaaagcgat aagcattgcc aagacggcag accctatcgc 2241961 tattttcaca gggtctccct ttactataga taaaattttt tctattagcg gatcaaataa 2242021 acctgcatca attaaaattc cgaaaaaaag aatagcaaac aatagcaatg ccgctgaact 2242081 tgcaactgtt tgaattcctt ctaaaatcat gtcgccaata cccttaccaa aacctccaat 2242141 aagagcaaaa acaatgggag tgatggtcaa ggcaacaata ggcgagactt tctttgtcat 2242201 tattaatatt gtaaaaacag ttaccatcga aaaacctaaa atagtaagca tattacacct 2242261 ccaagaatgc gctttcaaat gacttttgat taacatatct tatacggtgt aataagttaa 2242321 ataaatattt ttttactgtg tttcaaaaaa aattctatca taactttaaa tggttaccat 2242381 ttgttcaccc tttaaaaaat caatgaatgc tttaacgagt ttgattccta atgatttttg 2242441 atcgtacatt agccaagtat ctctcattag aggcttaccc ttagcattat acagttccat 2242501 tgtgtacaaa tgatcagatt cctgcaggca aatttctggt gctatggagt aaccaagacc 2242561 atgctttacc atctctttgc aagtctcttg tcgatccact tccattgcaa taatgggggc 2242621 ttgttttaga ttcgtatgca tccaatcttc tataatcgtt tttaaagaag catccgtttt 2242681 atatttgata aaaggtaaaa aaggaagttg ctctatcgtt attggttttt ttgagatgat 2242741 atgtaatttt tcccgtgtca gccgttcctc cacccctttc cagcgatggc ttcctctcag 2242801 tataccgact tgtacaatac cagcatctaa taatttcatg acatctgtgc tccagcctgt 2242861 ttgtacacta tattggacat taggatacat agtggaaaat tcccttaata acttagggag 2242921 cttatattga gcgaaattgc ttgatacccc cagccttaga tgtccttgca cctctttgct 2242981 tagattagag atatgatctt tggtatcttg aagttcctgt agcattcttc ttgcataagc 2243041 aaccaagtgt tctccttccg cagtaaaggt aattccttta tgccttttgg tgaataattc 2243101 aattccgaaa atctcctcaa tctttttcaa ccgataagtg atggaaggct gtgatgtaaa 2243161 taatcgttct gctgtttttg ttacactttg ttcttcgtga agaattttca ataaaatcca 2243221 atctttctca tccattttca tcttcctttc tagtccttct ttcacaatta taaaagtttt 2243281 tttatcgaat attaagaaaa cttatatttt atttttattt ttttaccttc tacactaaaa 2243341 aacataaaaa atactacctt taagatgagg atgatgacga tggtcaagac gaatgtaaca 2243401 atcatgagag gcggaacaag caaaggcgtt tttttccacg aatcagccat gcctaacaat 2243461 aaaaacgaat gggagccctt tttgcttgat gtcatgggaa gtcctgataa aagacaaata 2243521 gatggtttgg gtggcggtaa ttcccttact agtaaagtgg caataataaa gaaagcatat 2243581 acttcggata ttgatgttca ctatactttc ggtcaagtca gcatttcgga agaaaaggtg 2243641 gactttaagg ggaactgcgg aaatatctcc gctgctgttg gtccatttgc tattgaagaa 2243701 ggacttgtaa aagcgaaaga accaatgact gcggtaagga tcctgaatac caatacgaat 2243761 aaaatgatca ttgcggaagt agaagtggaa gacggtcagg tcaaatatga cggagatgtt 2243821 acgatatctg gagtacctgg atctggatct ccaatctatt taaactttca tgatgccgct 2243881 ggttcagtta ccggtcattt attgcctact ggaaatagtt cggagttttt agatacaagt 2243941 caaggccaaa tagaggtgtc tattatcgac tatgcaaatc cattagtttt tgtggaagcg 2244001 agcagtatcg gcctggatgg aacggaactt gcagaagaat ttactgatct acagttggct 2244061 caatttgaag aattaagatc cattgcggca gagaaatgcg gctttgccag tcgattttca 2244121 gctacaaagt tatcgccggc tgtccccaaa ctggctatag tagcaaaacc agagaaatat 2244181 aaagatagta caggtgcttg gcattcaagc gttgagatgg acttacacat caggatgatg 2244241 tccatgcaaa agccacatca agcactggct gtcactggag cgatatgtac aacaagagcc 2244301 ctttcagtgg aaggtgcaat ccctgcaaga atagcaaaaa accactctac aaaggttcgg 2244361 ctagctcatt cttctggtat tattgaaaca atggtggagc ccactggtat aaagatcgtc 2244421 cgtaccgcac gacgtattat ggacggaaca gtttatacgc atggagacta tcaaatgatg 2244481 tagatggact gtgcaaaaag cctcccccct ttccatcgtt aatagatgga ttgaatgcgc 2244541 cttcttgcac agatccattg taatcttgca tggctttaaa aaagcctcta tattgttttt 2244601 tatgaaatcg ccaaggtcct ttcatgtatc tgcctcaagc atgacataat cattatagag 2244661 aaaattgaat actttttact gcaaataaaa agataccaac atcattggta tcttttagat 2244721 tgagttcatc tgcagcggtt tcttttcctc actgcttatt tgattacaaa attaccgtac 2244781 tcgtttgaac gaacatgaat cggtccgttt agattatagt tgttctcctt ggcgatagag 2244841 cgaagcacgt ccacacgggc aactgattct ctccattcgt cacgggtgtc atgattggcc 2244901 ggattcatca gatcgtcata gcgtacgtcc aagaatttat tcaaccactt cttctcgtct 2244961 attccgtctt taggtgatcc gcccgctttt ttgttcgtac gtttaatcaa ggcataaaaa 2245021 gagtcagggt catcaccatc gccatgctga ataaccgtat cgtacatcac agctcttgcc 2245081 aatgctgttt ttagtccggc attatccgat cgtttcatgg caggctgata atacaaatgg 2245141 tcatttactt tgtcttgagc ggcgcgaaat tccttatcat ttgcaagcga cttccaggca 2245201 gaagcgaatc ccttgagatt gcttgtatca tcgctttctt ccttggccag acggcgcaat 2245261 tcaggcagat actttttcag tttgttattc ggaactgcct ttgtgtatac ttccactact 2245321 tccaatgcat ccccggtagc cgttgtaaag cctgcccgtc cgcatgtata gcctcgcccg 2245381 tcatccaatc gctctacata tccatattgg atctccgttg tgccgttttc aaagatactt 2245441 gtcagctgtt ccgcccggcg cttttgatct ttattcagtc ccgccgcaaa aaccgtttcg 2245501 ctcatcatca gggtaaaaaa catggtgaaa acaagtaatg agatcgctgc ttttttccaa 2245561 aaatctgctt tttgcatact gattttcatt tcacttcccc tttctaaata ttgtaaatac 2245621 agactcagta tacatgaaga aactgcccta ttgttgaaaa tacatcaatt tgtcaatatt 2245681 ttgaatctaa agtaatatag cttgaatctt actctattca ttgccaatca gccttagccc 2245741 ctctcactgg gaaggtccct tgattttcat actgcttcaa ctttcattaa caagatgcca 2245801 taaggcttta ctctatttta taatggaagt gatcatcgaa aatcgttagg gaggtgatgt 2245861 aatggcaagc aagatgagaa tgccagattc cgcaacgtcc catgcaaagc ctactattgg 2245921 gaaggcgata ctttgcatgg ggtagacttt ctaaaagatc gcccaagtaa gcttttctga 2245981 tatagtggct ttgcacctta tttgacataa aaaaataagg agctggcaga aatggcatat 2246041 gtaaaagcaa ccgctatttt acctgaaaag ctgatatcgg aaattcaaaa gtatgttcaa 2246101 ggaaaaacaa tatatatccc taaacctgaa tcctctcatc aaaaatgggg tgcgtgttca 2246161 ggaacaagaa agctgatcga tgacagaaac gcttctatta aaaaagcatt taaaaacggc 2246221 aaaaccattc atcaattatc tgatgaatat cacctctcta ttgaaacaat aaaaaaaatt 2246281 gtctactcta aataaacaaa acggaagcac tgataaaaaa taatcagtgc tttttatatg 2246341 gcgagtttgt ttcttagtta tttcctgcat atgataccat tggccaattg tgtaaagtta 2246401 agggagatga gaagaaagga aggtcctaca aatgacgata aacaatggaa cgttgcaagt 2246461 acccggcgcg aacatccact atcaggtgcg tggctctggt ccaatcattc ttttggtcca 2246521 cggaggaggc ggtgatgccg acaagttcca tcatgttgcc aatcatctgg ctaactggta 2246581 cacggttgtt acttatgatc gccgcggcca ttcccgcagc aatctcgcca atcagattga 2246641 gggttaccgt gtggaaacac acagtgacga tgctcaccgt cttctagcca aaatcaccaa 2246701 taagccggcc tatgtatttg gaagcagctc cggggctgtt atcgggcttg atctgtgcat 2246761 acgccatccc gaacaagtac atgtcatgat cccacacgaa ccaatcttat tgcagcttct 2246821 gcatggaaat gagctgaaac aagccgagca attcatggaa gaccttaaga aaaatcatcg 2246881 aagtgaagtc attaaattaa tgtcaagatt agagacagac gaacaatcaa aggctgtcct 2246941 gacaaagcgg cttctcggca attcaacgta tttcactgag tatgaaattc aaggaattct 2247001 cagctataca ttagatttcg aagcattaaa aactgtgttt acatcttcac cgatgaagat 2247061 actcccagct ggcggaagtg cttctcggga gctttttcct tatcgttgcg cgaacgccct 2247121 agcggaacaa ttggaaacag aatgggttga attccccgga aatcatacgg ggtacacaat 2247181 gtaccataaa gaattttctg agaggttaca cgacatgtta gaaaaagaaa agaaacatac 2247241 gtgttaagga ttgattaaaa ttttcaaaat aggacaggtg aaactaacta tggaattgga 2247301 gaagatttca cgaagcgtaa aaagaacttt tcactaacga gaacgcaatg tgagatgttt 2247361 aaccaaagtg atattaggga tttcatcgaa aaataggttt gtacattacg ttctcctatt 2247421 gattatttcc tatcttaatt ccgtatttta taccattaga tacaactcta aagcggctcg 2247481 ttattttgtc ctcaacaaca accagtgtct aacatcatga atctcttttg aaaatcacca 2247541 caaatgcagg tatggaagac ttcatcgcag caaaaaccat accaactatt gttgttggta 2247601 tggttcgtcc tagataggcc cttaagaaga gattctattg tacggagtat ttagctaatt 2247661 gcatttgtaa ccgacagggc cgtctgaacc tgtgtacaca tatgtgtcag acacatatcc 2247721 aatattcacg acaccccggg aatctttcca ctggatttgg tcccagatat tactcgttcc 2247781 atacttccct gtaacagtcg ttccataagc gtaacaataa taaggaacac gggagccact 2247841 cggaatggaa agcataatag gataatttgt accaggaccg ctgcgcatat tgacaggcgc 2247901 accgctgctt gttgagacag taaagtactg aacggcaagt gcctgactgg aaaaaatgaa 2247961 taaagatgca atcatcacgg ttaacatact cagcattttc agtttagtca atgtcatccc 2248021 tctttcttca attccttcat tttaagaaac gatagaacat aggctaccag ctgcatttag 2248081 gaacaaccgg accgtctgag cctgtataca tatatgtatc agagacaaat ccaggaacga 2248141 tctccccgct ggcaagcgtc cgctctgtgt aattccaaat attgctcgtt ccatactttc 2248201 cagttacagt tgtaccggtt ttgtagcaat agatcgggat gcgggttccg ctcggaatgg 2248261 tcgttacaat tccccaactt gtacctgggc cgctgcgcat gttgacagga gcaccgctgc 2248321 ttgttgaaac cgtataatac tgagccgcaa gtgcatggct agaaaaaatg aacacagatg 2248381 caatcatcac cgttagcata cttagcctct ttaacttatt caccttatac cctcccctta 2248441 taaatgccgt acgtttgact ttcttacatc cagttaagga tttactttca gataccatgc 2248501 cccctcccct cccatatatt tatcaatgta ccataaacta gatctttcaa aagtggaatt 2248561 attcctatgt tttcgacaat taaggataca aaataaatgg tagtcaggct tgatattgat 2248621 ggtgtgttac atttggctct taatcatttg tccagtcggt aatcacgatt gacaatcagg 2248681 aaaaaggaca tggatcaagc ggcttcgttt ccaccaatta actcaatcag tgtactgctt 2248741 ccttgtatcc acgcttcttc tcgattcata gatactccac ctttttcacc aatcaaaaac 2248801 ggacaccata caaatcagcg taaatgctgc aagttcagtg tccgcaacct attatgactt 2248861 tgctttcttt taccagggcg tgtaaaaatg attaggtacg ttatcaaacg ttattctatg 2248921 attttgcgag tcaaaaaatc ataacatttt atatatttca atcagattat gatctggatc 2248981 tctgaagtga gcaactcggg cactccattc cttgcgatca tgcggtttat tctcacattt 2249041 aactcctttt tcgtgtaaat cgtcatacgt tttatcaaca tcttctacct taaactgaag 2249101 caaaaatttt gattgagctt ctccttccaa ggactttttt tcctctccaa cgatttcagc 2249161 catcgtttct cgagataaaa gctctatttt cgtttcccca ttatcaaaga gtgcatattc 2249221 catttcattc tctaaccaac ttattggaag tcctaatgaa tctttataaa actcgacgct 2249281 tttcttaaaa tcattcacca acagtctaat ttgtaacagc ttcatatcga gtgcctccta 2249341 taaaaccata cttttactgg tcatccaatt taatgatacc aaagaaacct gacagcacta 2249401 tgtcaagttt ccatacttca cccttatttc agatttaagt gcagtttagt ccatgtcata 2249461 agaacgagca aaaacagcga ttcttaaaac aaaaaatgat accgagtgta ttttctgtat 2249521 gcttcaactt catttcggga aatgtaacgt tgataaaagg aggttacatc aatatggatc 2249581 atcaaacatt ggcagctcat gaggctgttg acttacatga aatcgtgaac tttaaaacac 2249641 tttgtatagc gaaatcaaag ttaatgcaag ggcttgtgtt tgaccaagaa ctgaaggact 2249701 tgatggaaaa agatgtacag caatccattc aagaccttac tgaattacaa gcggtttatg 2249761 agcgtgcctc atttcaggcc cctgtccctc aaagccgccc aacgccaatc atcaattgaa 2249821 agggaggtaa gcctctttga ataatgatca tttagacccc attaattcgc tgaatgtgcc 2249881 tgaactagca gacactacat tcgcgatgga ttttcttata cgagctaagg aaggcgtaag 2249941 gaatactgct gtagctttga cagaaaccgc ttcaccagat gtaagagcac tgcttcggaa 2250001 acagctgatg caaggaattg cgatgcacca agagattacg gaactgatga tcagcaaaaa 2250061 gtggttccat ccatatgagc tgagcgaaca gtataagctg gatcagctct ctgcaaaaaa 2250121 cacgatcatg gtcggcaata tgaacctctt tcctgatgaa acaaatcgca aagggatgtt 2250181 tgaccggaca cctgatgaac actaacactg gaggttttac agcatgaagg cagtaacgta 2250241 tcaaggcatt aaaaatgttg ttgtcaaaga tgtccccgat ccaaagattg aaaaatccga 2250301 tgacatgatt atcaaagtca ccagtacagc catttgcgga tcagatttac atttaatcca 2250361 tggattcatt ccgaatatgc aagaagacta tgtcatcggc catgaaccga tgggaatcgt 2250421 cgaagaagtt ggttctgggg tgactaaact aaaaaaggga gatcgggtaa ttattccctt 2250481 taatatagca tgcggggaat gctttttttg taaaaaccag ctggaaagcc aatgtgatca 2250541 gtctaatgac aatggggaaa tgggtgctta tttcggctat tcagggcaaa ctggcggtta 2250601 tccaggcggg caagctgaat atttaagagt gccgtttgcg aattttaccc attttaaaat 2250661 ccctgaatct tgtgaggaac ccgatgagaa attaagcgtg attgccgatg ccatgaccac 2250721 cggcttttgg agtgtggata atgccggcgt aaaaaaaggc gatacagtta tcgttctcgg 2250781 ctgcggacca gtcggcctgt ttgctcaaaa gttttgttgg ctaaaaggcg caaaacgcgt 2250841 catagcagtt gactatgtaa actatcgctt acagcatgcg aaacgtacaa acaaagtaga 2250901 aatcgttaat tttgaagacc atgagaatac agggaattat ttaaaggaaa tcacgaaagg 2250961 cggagcggat gtagtcattg acgctgttgg gatggatggt aaaatgagcg atctcgagtt 2251021 ccttgccagc ggcttaaagc ttcatggcgg aacgatgagt gcattggtca ttgcttccca 2251081 agctgttcgc aaaggaggaa ccatacaaat tacaggtgtg tatggaggca gatataacgg 2251141 ttttccgtta ggagatatta tgcagcgaaa cgtcaatata cgctctggac aggctccagt 2251201 gatccactat atgccgtaca tgtttgaact agtatcgaca ggcaaaattg atccgggaga 2251261 tgttgtcagc catgtcctgc cgcttagtga agccaagcat ggctatgaca tttttgattc 2251321 aaaaatggat gattgtatca aagttgtgtt aaagccttaa aaaacggagg ttacagaaat 2251381 ggaatacgcc ttacacgaag tgcttgaggt tcaggaaatg actgcattta agacactttg 2251441 tttgacgaaa tctaaaacaa tgaaagcact ggtatctgat ccgaagctga aagaaatcat 2251501 gcagcaagat gttgatatca ccacacgcca gttgcaggaa tttgcctcta ttttatctaa 2251561 tgcaaagcaa gaatgaggag atgaataaat catgaatcct atcatagaat atctgactgg 2251621 catgaatgtt ctaacagacc aaatcattgc tatggactta ttaatttcag caaagaacgg 2251681 agtcagaaat tatgcgatgg cagccactga agccggaacg cctgaagtaa aagaggtcct 2251741 tatccgccat ttggaagaag cactcgatat gcacgaacaa ctctcaagct atatgatgga 2251801 aaaaggctgg taccatcctt ggaaccctga cgaacaagtc aagctgaatt taaaaaatat 2251861 tgatacagcc attcaattgc caacccttta acatacaatg actgatttgc tgaggaacag 2251921 tattgattgg ccacaactgt tcctcagctt caaaatgagc actgtttgtt cgggtcctat 2251981 gaccgtaaat agattaaccg cttttctcca tctgatctcc gataatgttt gcaaattctc 2252041 caatccaaat aaggaatcgt aaccacctct ttttatgcga tctcttgatg gagaaaacag 2252101 gccagaaaca aaatccttcg tttttgacct gccctcttca cacgcaaaga atgctacctt 2252161 ctttgctcca ctgatccgtg aagactttcc gttttaggcc tgcttttgag ctttgcctca 2252221 ttttcacgca atttcccatc ataatcttta atttttgtgt ctaatctctt aattgtttca 2252281 tcaatttctt tccgcttctc tatcagccgc tgtcgttcgt cagccaggat attttttcga 2252341 gcttctaccg tacggtcacc ttcggtaaat aatgttgtat attcaattag cgcttctatc 2252401 gatagtcccg catttcgcat gcatttaatg aattcaatcc atttgatatc ttcttcatca 2252461 tagtcgcgaa tgccgctgtc ttttcgtttt acaggcggga ttaatcctac acgttcgtaa 2252521 tatcggagtg ttgcggctgt caggccaaac tgctttgcca cctgagcaat attcatgatc 2252581 ttcacctctc tatcctgtat gttgtgaagg taacacttaa agttaacttt aagtcaagct 2252641 caaaacaagt ggttagctgc tgaatctggg tttatatatt cgggacttgc cttaaagcac 2252701 actttaaact ctatacttct ccatgcacta aaaacagtgt agttggaggg attgctgaat 2252761 ggcaaataaa cacactgccg gaagagaaca attaggagaa tttgcgccaa agtttgctga 2252821 acttcatgat gatgttctat tcggtgacat ttgggcaaga gaagaagaac tttcatcccg 2252881 ggatcgcagc atgattacag tttctgcatt aattactgac tgtttctcag cttataaatc 2252941 aggttcattt taaatggttt ttttaaaaaa cccttgcctt aaagcagact ttaaggttta 2253001 tcgttatgtt gaagacacca taaaacataa ataagtgcat gtttttattt acaacactta 2253061 tgatgaagaa aggataggtt cgtatgtgta atcaacatca aacccgtgta ttaagcgtgt 2253121 cacatgcaaa agccaaattt gaacaaacga cgattgagcg aagaggatta cggccgcacg 2253181 atgtcttaat cgatattaaa ttcagcggca tttgccattc agacattcat agcgcttttg 2253241 atgaatgggg cggtggcatc ttcccaatgg tgcctggaca tgaaatagcc ggtgttgtaa 2253301 cagccgttgg aacaaaagtc accaagttgg ctgtcgggga ccgcgttggt gtcggctgtt 2253361 ttgttgactc ttgcggagaa tgcgaatact gtctcaacgc agaggaacaa ttctgcacga 2253421 agggtgttgt tcaaacgtat aactcagtag actacgacgg aaaccccact tatggcgggt 2253481 acagccaaaa aatcgttgtc actgacagat ttgttgttcg cataccagat cgtttggaaa 2253541 tggatgttgc cagtccgctg ttgtgtgcag gtatcacaac gtattccccg ctgaaacact 2253601 ggaatgttgg ccctggtaaa aaggttgcga ttgtaggcgt aggtggcctt ggacatttgg 2253661 caattcaatt tgcacatgcg atgggtgcag aagtaaccgt cctgagccgt tccatgaata 2253721 agaaagagga agctctggaa ctcggtgcaa atcattactt tgcaacaagt gacccagcca 2253781 cattcactgc attggccggg cgttttgacg tgatcttaaa tacggtatcg gcaaatctcg 2253841 atgtagatgc ctatttatca atgcttcgta tagacgggac acttgtaagc gttggagctc 2253901 ctgccaagcc ggacacatac agtgtgtttt ccctaatcat ggggcgccgc agcattgcag 2253961 gttctctagt cggcggaatt caagaaactc aagagatgct ggatttcgca gctgagcatg 2254021 gcatcgaacc taaaatcgaa gtcatcggag ctgaccaagt ggacgaggca tacgaacgta 2254081 tcctccgaag cgatgtccgt tatcgatttg tgattgatat ttccacattg taataggtta 2254141 gtccttatat gggctgccgc ttttattgaa actcacgaaa aatgatctct ttaagcaaat 2254201 attttgaagg ccggtcaatc ttcctgttat tctatgaata gagagttatt aggagggttt 2254261 tttatgagca aaaaaattgc agttcttgtt acagaccaat tcgaagacat cgaatataca 2254321 agtccggtaa aagcatacga agaagctggc tacagtgttg tggctatcga tttggaagcc 2254381 ggcaaagaag ttaccggtaa gcatggcgag aaagtaaaga ttgacaaagc catctctgat 2254441 gtggatgcaa gtgactttga tgcactttta attcctgggg gattctctcc ggatttgctt 2254501 cgtgcagatg accgtccggg tgaattcgca aaagcatttg tcgaaaacaa aaaacctgtt 2254561 ttcgcaattt gccacggccc gcaagtactg attgatacgg atcttctaaa aggcaaagat 2254621 atcacaggct accgcagcat ccgcaaagat ttaatcaatg ccggtgcaaa ctacaaagat 2254681 gcagaagtag tcgtcagcca caacattgtc acaagcagaa cacctgatga tttggaagca 2254741 tttaaccgcg aatctttaaa cttgttaaaa taacaagaag gcacagactg ttcgggtctg 2254801 tgcctttttt aaaattaaga ctccttcgtt acattctgaa agacagcagt cgcgtcccac 2254861 acattcaagc caaattggcc ttctgaaaat acggaatcat gtgcatcaat cacaagacga 2254921 tcatctaaat agattttaaa gcgatcgccc tcggcctctg ttttcagatg atacttttta 2254981 ttaacgtcta tcggtgtttt gtattcagca atgacagaag cagcaccgtt ctcaaattta 2255041 aagaatttca ctaggtcatg cttcgcatcc acattggcaa ggtaaccgtt tttggcatct 2255101 ttgtcagagc gaaacattag tgctcctgcc cctcttccgt ttccatcctt aatggtgata 2255161 tcagattcat aagtgaagtc tgacccggat gctgaagaca agataaagga atcgccgtcc 2255221 gacctccctt gtttcccctc aattgtgtct gcccacgtgc catttacagt cgtccagcca 2255281 gtcatattgg acataaaagg tgtcgttccc catacctttt ttaaagggtg tatcgttaaa 2255341 gattttacct ttacaccgcc atttgcagca tataattcaa gccctttgct tgatcggtct 2255401 gggagaataa tatccgttat gacctgcttt ccgtcattcc caaatacttc aaccgaggag 2255461 cggtcaacaa aaatgcgcaa cttaaccttc ccatttaccg gcttcaacgg ggctgtttct 2255521 tttccggtgt taaaggccgg attaaaggtg tcgttgcctg actcgctccg gtcaacgaac 2255581 aatttggcgt tccttcggtc atagccgacc ttcgtaaatt gattttcacc tgttcggacc 2255641 ttaaaaccaa attcagcagc tgaaccaggg cttactttaa attctgcatt tatttcatag 2255701 gcatctccag attgccccgc taacacatta tgacttgcag gcgatatggt cagattcttc 2255761 cacttcttag aggttccgcg aatggtttcc agctctttca ccggtgtttg gaccactcta 2255821 accccttcgg taaacgcttt caattttaac tctcttggaa tggacgttgc acttctccat 2255881 ggggatgtcg gaacatcatt cgcatattgc caattgctca tccaccctaa ccatagccgg 2255941 cggctgtctg tggatggaat atcagaccag gatacagccg cataaaagtc tctgccgtaa 2256001 tccgtccaga gaactttgtt tggcgggttt tcatttttaa aatgagttcc atcaaagtcc 2256061 cctacaaaat attgcatgcc tgatcctccc gagaccgctc cgtttccgac actgacctgc 2256121 atgacccatt tcttttgatt cggattgccg tctaccggaa gctcaaataa atccgggcat 2256181 tcccatactc ccccgtggct tccttgatcc tgtccaaatt cacttgcata cgtccactgc 2256241 ttcagatttt ttgatgtata aatgaggatt cggtcaccgg ccgcaagcac catcacccac 2256301 tttttttctt tctcatacca aaagactttt ggatcgcgaa aatctttttt acccgggttt 2256361 ggaatgacag ggttgccagc gtacttcgtc catgttcttc ctttgtcgtt gctataggca 2256421 atactttgca cttgatggcc ttcccgatcc tgtgtataaa tggccacaag cggcttctct 2256481 ttgcctgttt gaaaaccgct tgtgttattt ttatctacaa ctgcgcttcc agaaaagatc 2256541 gtgccttttt catccggata cagcgcaaca ggaaggtgtt cccatgtaac caaatctttg 2256601 ctgacggcat gcccccaatg catgggcccc cactgaagcc cgtatggatg gtattgatag 2256661 aacaagtgat attccccagc ataatatacc attccgtttg ggtcattcat ccagtttgcc 2256721 tccggtgtga agtgatattg aggacggtaa tcctcatcat agtagcttga atcggctgca 2256781 tctgccgaaa atgccatagt caacagcagg gtgaacatga tcatgacttg aatcagtctc 2256841 tttttcattt gttccttcgc tcctctcttc atgtttgaac actttcaaaa gagactgctg 2256901 cgcaagctgg tccgtttctg gcaattctcc tctgtttcac tgttatccga atgatttata 2256961 tatgaaaaga ctgctgcagt ttctctctct ttccttcaca caccttatgc taagaatcca 2257021 gcccaatacc cgagaatccc gatgacaaag atgccgcaaa taatgagaag tggattcacc 2257081 cctttgcgaa gcatccatgc caccaataac gttaatccga gaggcagcgc ccccggcata 2257141 atgctatcta gcacgttttg taccgtttga acatctactt ttccgctttc atccttaatc 2257201 ctggatacaa cgattggaat gttgatggtg gtccatttgg acacgagagc ccccataaca 2257261 aataacccga gaatcgaagc gccctctgta agcttttgaa tgcgattccc cgctaaatcc 2257321 tgaagaatct ccattccttt cacatagcca tactttaatc cgtaatattt tgtgcttaat 2257381 cttatggcat tcagcaagaa aaagaatagc aaaggaccgg caatgtttcc tcctaaagca 2257441 agggaggctc ctagcgcagc taagacagga cgaatcgttc cccaaaaaat tggatcgcct 2257501 acgcccgcta ttggtcccat caaaccgatt ttcattccgc ttatcgcttt tccgtcaatt 2257561 cctttattgt tcgccatttc ttcttccatg gctgccgtca cgccaaatat aggcgctgtc 2257621 agccacggat gtgtattaaa ccattccaaa tgccgctgta aggcttcgtt tcttttcgct 2257681 ccgggaccgt acaatttttt gatcgccggt atcatgacat aacaatatcc cattgcctgc 2257741 acacgttcga agttaaagga accgagtaaa aaatttgaac gaataaacat gctgaaaatt 2257801 tctttcttcg ttaatcgttt ttctttctcc attttttctt ccccctcatc gtttaggcat 2257861 caagatcatc atcatcgtca tcataaacag caacactgcc actgtctgat gcggccgcga 2257921 ctgctccgtg agcgctttgt ttttgcatca cctgctggta taaaagcgcc agacagagac 2257981 caagggctcc aaatcccact aagttaaaat cggtaaacgc cgctaataag aaaccaatat 2258041 agaaaaatgg ctttaaataa ggaatattca tcatattgat caccatggca tacccgacaa 2258101 ccacaataat gcctccgcct atttgcagtc cttttgtaat gacatcagga atatttccca 2258161 ggaacgcctg aacagcgctg acactaatta aagcaacaat caatgtagga atcatgacgc 2258221 gcaaagcttg aaacaccatc gcggtaatat gcataatttc aattcctttt atatttcccg 2258281 cttttgcata ttgatcagcg cggtggatga aaaagacagt gatcgtccga acaaaaatcg 2258341 tcagcgcctg acccgcagct gctaaagcaa cagcgacagc aatcccttcg ccaattcctt 2258401 gatcagcggt aataactaaa atggttgaga tgacagaggc gatcgctgta tcaggtgcca 2258461 tggcaagccc gacgttcatc cagccgagcg ccatcagctc cagtgtgcct ccaagaataa 2258521 ttcccgtttt taagtccccg agcaccaagc caaccaacgt acaggccact agcggccggt 2258581 gtgtctgccc ttcatccaat acacttgcga ttccggtgat tgctgcaatg attaacaaca 2258641 aaataatttg taatgaagac atattctcat ccccttgatt attttgttac gttccgtaaa 2258701 atctgtacaa aatcctcact ggcatctgaa ggcagctgcc tcaattccag tttcacgccc 2258761 ttgtcactta atgtttcaaa tgcctttata tcttgttctg tgacactgac tgattttgtg 2258821 atttgcctgc gatgattttc aaaacgcatt cccccgacgt ttacggtttt gatcggtaca 2258881 cctgcttcta taagagatac aatatcggac ggattttcaa acaagagcat tgccgttacc 2258941 ccttcgtagc gcggactatg aaatgctttt gccattttag aaaccgagac ggcactcgcc 2259001 tttacatttg aaggcgcaac agaaaggatc agcgtttttc tcatttcgtc ctgagcaata 2259061 tcgtcggaga caacgatgat tcggtcggct gcatggactt ttatccacct tgtcaggatt 2259121 tggccgtgaa taaagcggtc atcaattctt gctaacacaa tgttcatcat aattcatcct 2259181 ctcttgtatc ttgattggct gtttttactt tttctaaatg ttcactgcac acttgaaagc 2259241 tttgctgact cattgctttt aagttgttca gcaaatcttt gagagccaga tgttctctca 2259301 ggcttaatac ctccagcaga atcggcaggt ttacgccggc agccatatcc attctttgat 2259361 cctcagcaat aaaggaagct gccgcgttat atggcgtccc tccaaaaata tcgactaaaa 2259421 aaagcacttc atgttcttcc gggatatcct tgagcgcctg atgatatttt tcttgcagcg 2259481 tttgtattcc ttcccctttg aaaaacggca ctgcaatcag gttattttct tcaccgaata 2259541 tcatccctga agactctttt aatgctatgg gaaaatctcc atgaccgctg ataataactg 2259601 aaatcatatc tattgctcct ttcctgtttt gtacatccat atataatgca aggatcgtgc 2259661 caacacagtt gtgttaagcg ttttcattgt tatttcagcc aatagcaatt tgttgttgaa 2259721 acacttaaaa cgaaaaaaat aaacctgtat taaaatggtg ttccatttaa tacaggttca 2259781 tatgaaaaaa ctgtttttaa aacagctggc catgcacttc ttcagcaaat atggcggcta 2259841 taaataattt ttcatcatca cttatgcgaa gtccgagctt ttcttcataa ggggctaatg 2259901 ttcgctctgt cacgtacacc atttccttca gctgatcatt gatctcttct tcctctgaga 2259961 aagcgatcgg attctgctta attacccttt caaaggcgaa agccgtgtgc ataatgactt 2260021 tgatcaaaac cgcattattg aaaatgaccc ccagctcatc ctgaacggtt tgcagccact 2260081 ccaataacat gtcgatcaca tggtggggat tcaagaagac aaggtatttt ttcaggctat 2260141 cctcgcaaag ctccctgaca ataatatttg cttcgttcaa tccattgctc aaggagatgc 2260201 ttccttttgt aatcgcctgt tgaatcagct tctctccctc cccttcaatt aacacttcta 2260261 aagatacatg cggagcattg attttagggt ctttcgttcc gactgtcgca aggatttcat 2260321 actctttttc gatttctttt atgctgttgg ccagcttaat cgatgatacg gtcaatatgt 2260381 gaatgggggt atcggaggcc ttgtttacga tcgtggttag aatgtcttcc agctttttgg 2260441 ccgttccgct acccgtcgtg cagatggata ccaatgcctt ctttttgccg gatgccgctg 2260501 gctgacgctc ccacaactcg ataaaatcct tcgtgaccga ttgatagatc gcatgcaaat 2260561 ttaaattcaa atagttgacc tttctgacag catccagcac cattgaagtc gtaacattgc 2260621 tgatcgtttt aatagaaatg cctgtctttt cctccagcct gctttccagc attgcaagcg 2260681 accccatatc taccagcatt aaaacacctt caccttcatc aacctgtttc attttttctg 2260741 ctacgcattc aagaatgtcc gaaggtgaaa cagtaagcgg catgtcaact gctgcaatcg 2260801 gcgtactccc tagcagttct gtcgcgactt caaccattga actcgccgtg ctgtttccat 2260861 gagctgccac gataataccg actcttttgt tctcctttaa cgatttgatg gaatgaatta 2260921 acatcgttaa gtagatgact tctatttcag gaatagccac tttaaaatat tcctgaattt 2260981 tatctttaaa aatcatcgcc acccgatatt ctttcacatg ggtatcacga atttcatctg 2261041 tctcctgtgt attcaaaaca tcaatttgct ttcctcgctt taaaaatgcg tcaatatgca 2261101 tactcaagaa ataaataaac ttacggtcaa atgtgcaatc cagctcatgt tcagctattt 2261161 cttttaactg ttttgtcatt tgaatcacat cgtcttcaac gaatgtcagc aggttgtctt 2261221 tttgaaaagc ttgatgatga aaaaaacttc tgacatgcaa atggacatca gtcaagatgt 2261281 actggttaat atcctttttg gataaacctt ctttcataag cgttttcact ttttcctcaa 2261341 tcaaatgata taagttaaat gagaggtctt cgtcaatttt tgttgtttca tcttctacaa 2261401 tcggagagat aatcgttgta atattgacat attcagaaat ggctttgctt ctttgcatgt 2261461 ttttgctgct ggacatccat tcttgcttga tttcatcagg cagatcgcga acagtcagtt 2261521 caataacttc atttctgtca aggttatgca aaaatccgtg tgcgcaaact aactgaacat 2261581 ttgatttcag ctgtccgaca ttcccaaatt tcgcagagtg aataagcgca ttatagacat 2261641 cgatatgcac actcagattc ttcttaattc gctctgcttc tttccctaat aaaaacgtcg 2261701 tcagatccac tctttcatta agcgatcgtt cttcaagcga aggaatatga atggtcattg 2261761 ggattcttcg caaaaacgtt ttcaatagtg cagaactcgg attttctgta gtcgcacaaa 2261821 taaacaatac gttcgatgtt cgtttatgtt cagattctcc aagcctgtta taagaaccgc 2261881 tgtcaataaa ataaaacagc atttcttgtc cctcgggagg gagacggtgg atttcatcca 2261941 taaaaagaat gcccccattg gcctgttcga ctaaacccgc cttatcctcg gcagcacctg 2262001 taaatgaacc ttttttgtgt ccgaataatt gagaaagcaa taattgaggg ttgttgtagt 2262061 agtctgcaca gttaaatgta ataaatggtg cgccggcctt caatatgtca gagtaaatgg 2262121 caaactggta aattcggttc gcaaaaaggg atttaccgga accagtcggc cctaggagga 2262181 gcatatgcag accgttcggc ggataaaaga cagctgcttt tgcctgggag atcgctttct 2262241 tcaaactccc ttttgcccct atcataagct ctaggggatt cgtggaaatg tgttgatgat 2262301 tttgctttga atttccggaa aacgcctgaa ggtctttcac ttccatcatc tctgtatccc 2262361 atttcttgtt gaataatttt tctgctatct cgactgggat gtatcttaca ggaaatgttt 2262421 taattttgat gacctttttg gaccggacga gattgttcaa ttcaaagctg acattggacc 2262481 gctccatttt cagctgctcg gcaatctcct ttgctgaatt cccttgtatt tttaaaagat 2262541 gatctaaggt tgaatcatga aaattatgct tgagctgatg gtatatttta tctattcttc 2262601 tcacgtctat catcctttgt ccttattaga taagccatta acaagaatat ttcgaaactt 2262661 tatagtccgc gttgagattt acacgtttaa aaaggtctct atagcagatt gacaaagctg 2262721 gcttttatgc gtatatgttt acatgttgaa tcatttgcac ctcatattag tatgatagat 2262781 gctcagttct ggagggccag tccccttcaa aagtaataat cagtaaacag tttatcattc 2262841 tcggggaatg taatgatgtc aaaataatca atgacaaaaa atgaatctta tagatcatga 2262901 caaattaccc aaatataacc ccttaagttc gttcacaact aaaaagacgg acactctatg 2262961 tgaccgccac agtattacaa tttgcaaaac ttcgtcattt ttgcaatcca cattggaggt 2263021 taaggaatct gtaagcttaa aaactttatc tccgatccta tcgatttgat ccccctgccg 2263081 gcctcaatca tagtgggtat gcaattatac aaatcgttac cgattaaaac tagcctgtca 2263141 gattgtccaa atgactttcc tgttttactc tgctattcag gtagaatcac gagtgaaaaa 2263201 tagagccaca agacatgtaa cagcacttaa aatagtttta aaatttaaaa ataaaagtat 2263261 ctattctttt aaatgttata atatccgata aaactttact catcttttta ttactggagg 2263321 aaaataaaat tgataggcaa ttctagcaaa gacaattttg gccagcaaca gaaattgtct 2263381 agaggcctta aaaacaggca tatacaatta atggcgattg gaggtgcaat cggtacaggt 2263441 ttatttttag gttcaggtaa atccatccat tttgcaggac catccatttt atttgcttac 2263501 ttgatcaccg gcgtattttg ctttttcatt atgcgttcgc tcggagaact gctcttatca 2263561 aatgcgggat accactcttt tgttgatttt gtaagggact atttaggaaa catggcagca 2263621 tttatcactg ggtggaccta ctggttctgt tggatttccc tcgcgatggc tgatttaacg 2263681 gcggtcggca tttatacgca atattggctt cccgatgtgc ctcaatggct gccgggtctt 2263741 cttgcgctta ttatcctgct gatcatgaac cttgccaccg ttaaactttt cggagaatta 2263801 gaattttggt ttgcattgat caaagtcatt gccatactgg ctctgatcgt aactggtatt 2263861 ctcctgattg cgaaaggttt ttccgcagct tccggccctg ccagcctcaa caacctttgg 2263921 agccacggcg gcatgttccc aaatggatgg catgggttta tcctatcttt ccaaatggtc 2263981 gtcttcgctt tcgtgggtat tgaacttgtt ggactgacag caggtgaaac agaaaatccc 2264041 caaaaagtga tccctaaagc catcaatcaa attcctgtcc ggattttact tttttatgtt 2264101 ggcgcacttt tcgtgattat gtgtatctat ccttggaatg tgttgaatcc aaacgaaagc 2264161 ccatttgttc aggtcttctc tgcagtaggc atcgttgtgg ctgccagttt gatcaatttt 2264221 gttgtattaa catcagccgc atcagctgca aatagcgctt tattcagcac aagccgaatg 2264281 gtctattcac ttgcaaagga tcatcacgca cctggactat taaagaaatt aacttcttct 2264341 aacgtgccaa gcaatgcgct gttcttttca tccatcgcca ttctgattgg cgttagtctg 2264401 aattatttaa tgcccgagca agtcttcacg ctgattacaa gtgtttcaac aatatgcttc 2264461 atttttattt ggggcatcac ggtgatttgc catttgaaat atcgaaaaac aaggcagcat 2264521 gaagcgaaag caaacaaatt taaaatgcct ttttacccat tatccaacta tttaacactt 2264581 gcatttctcg cgttcattct tgtcatattg gcactggcga atgatacacg tattgctttg 2264641 tttgtcaccc cggtctggtt tgttttattg attattttgt ataaggtgca aacccgcaga 2264701 ggacataagg tgaaataaaa aaaagacaag ggatactcac tcccttgtct ttttatatgt 2264761 gtcaaacact aaattaaact ttggtttcaa atttcattca cttcatttaa gtgttaactc 2264821 aaaccagttt tgatgccgaa acctactaat attattccgg taattttttg aaacactttc 2264881 tggaacttcg agtttttcat ccattttttt gcgtaatcaa taatataaac aagaaacagg 2264941 aaccacaaca ccgctaataa ggttaggatt gaagctaaaa tgatgagctg ctggtttata 2265001 tttccgttca aattgataaa ttggggcatg attgtaacat acaccaaaac agttttagga 2265061 ttgagaatgt tactgagtga tccctgcata aaggaagttt tataataacg tttcggagaa 2265121 cttgccatat tttttgcttg ggattgcatg tcatctaacg aaaacatact tttagcaaaa 2265181 aaacttttta cacctaaata aattaagtat gccgctccca aatatttgat cgttgtgaaa 2265241 agaatcactg actttgcgat taccactgat aatcctaaaa tggcaatcac cgtccaaaag 2265301 gaaagtcctg tcgccaatcc gagaatgtta taacggccgg ctttcggacc atacctaagc 2265361 gtatttttca tcacaagcat cgtatctgcc cccggtatga taaccatcat ggcagcgatc 2265421 ggtatgtatg cgagtaagct gtgcattgtt ctctccccct ttaaaaatcc cctcaatcat 2265481 atagtgacta caaaagtaac tacttataaa agtgtatcaa tgcgtttgga ataaatcaat 2265541 atgatttgtt aaaatagcga ttactaaggc agcgattgct ctttatattg gaggatatat 2265601 gaaagaaaat atgttagaca ttttaaaaaa cctcaatttt acagaatatg aatcgaaagc 2265661 gtatttagca ttattgcaag aatcaccttt aacaggctat gccgttgcca aaaaatccgg 2265721 agtgccccgt tctaaaattt atgaagtatt ggaaagtctt gtcataaggg gagatgtttt 2265781 tgtcagtcat ggaaatacgc ctcagtatgt tccagtcccc gcaaaagaac tgattaaaaa 2265841 ccgccggctc aaagcggaag agcattttga tcaggctgag aaatattttg aaaagttcga 2265901 gcagaccgca aatgaccggg aaaacatctg gaatatcacc ggccgcagtg aaattcttga 2265961 aaaggtgaag gcttgtatct tatctgccaa aaaaagaatc ctcttagaaa tatggaaaga 2266021 ggattttaag gagatagaag cagagctcaa acaggcggca gaacaaggcg ttattgtcac 2266081 cattattgcg tacggagaca tcgtatctga ttttgccaat gtttaccttc atgatatgag 2266141 cagtgaaatt acagaagagt atgacggacg gtggcttgtc tatagcggag atgattcaga 2266201 agtagtagcg ggcattgtct cacttggcaa cgacagccgt gctgcatgga cgatgcatgt 2266261 agggttagtc atgcctatta ctgaagtgat cattcatgat ctgtacctca tggaaattct 2266321 gaaaaagcat agagagcttt tagaagagag cttcgggaaa aatctcatcc agttgcgccg 2266381 taaattttct attcactcag atttcaaaaa acattatttg gaataatgtt tgtcatctct 2266441 taccccaaaa acaaggcttg tacaaaacaa gccttgtttt tttatgcata aaccccccat 2266501 gctgatttac ttctctcttt taaaaaatgt gattctgcgc aaactatttt tcagcctgcc 2266561 gcgtctatcc taggtaacag cctacgatat acgtatattc aaaaaggagc cctttattgc 2266621 aatgaagaaa aaacaaacaa caaaagcgtt gcttgtcaca tgcataactg accataagca 2266681 agatttctac aggttggctt tcagttatgt gaaaaatcaa gatgacgcat tagatattgt 2266741 tcaggaatct ataaaaaaag cgctgagctc agttgaaacg gtcaggaacc ctgagacgat 2266801 aaaaagctgg ttttataaaa ttttagtacg gacagccatt gactttttgc gcaaacaaaa 2266861 aaagataaga gtgatggacg acgaaacgat agaattttta agcaaaggaa aggaagacca 2266921 ttacaaggat actgatctcc atgaagcgct tgacgaattg ccgtaccgct ataaaaccat 2266981 tattatttta cgtttttttg aagacctcaa attagaagaa attgcggaaa ttacaggaga 2267041 aaacacgaat accgtcaaaa cgcgcctata cagagcattg aagctgatgc gcattcagtt 2267101 gacgaaggag gatctttctt aatggataag agattacagc aattaagaga agaatataaa 2267161 aatgttcaga ttcctaaaga attggatatc attgttgaaa aagcccttca gcaagaacca 2267221 aaaaagaaaa gaatcgttat gtggccgaca tcagcagcaa tcgctgcagc tattttattc 2267281 actgcgcttg ttaatatcaa cccggacgcc gctcaggcta tgtcaaagat ccctgtcatc 2267341 ggcaaaatcg tcaaagcgat cacctttatt gaaatcaaag aggaaaaaga ccaatcaagc 2267401 attgatgtca aaacacctgc tttgtccggg ctttctaata aagagcttga aaacagcatt 2267461 aacgagaaat acttgaaaga aagccagcag ctgtataaag agtttataca gtccacatcc 2267521 aaaaacaaaa aagggcatct cagcatctac agtgattacg agacggtcac agacacgcca 2267581 gatttactct ctatccggcg caatattgaa acaacacaag catcttccta cacacaaagc 2267641 cgttatatta caattgacaa aaagaatgat attttactta cattaaaaag cttattcaaa 2267701 gatgagcgct atatcaaagt catcagtcaa aacatcaaag aacaaatgaa acagcaaatg 2267761 aaggaagatc caaataaaat atattggctc actgacgaag atgcagaacc gttcaaaacg 2267821 attcttcctg atcagacgtt ttacattact gaagaccata aacttgtgat ctcatttgac 2267881 gaatatgaag tcgcccccgg ctatatgggc gttacagagt ttacaattcc aaccggcgtc 2267941 atttcaaact tgctcgtggg agaacgttat attcgataaa ataaaaacat ccatctaaga 2268001 ttatggatgt tttctctctt ctctattcga ggtcgtaacc ccgctatcaa aaacaacgag 2268061 aatatttgca tactattgga ggaataccca tgtatcacaa gacacagcat catcgataca 2268121 ttcctggact tgatggcctt cgggctttcg ccgtcctgtc agttatcact tatcacctaa 2268181 atttcaattg ggctaacggt ggttttatcg gggttgatat cttttttgtt ttatccggat 2268241 atttgattac atctattcta ttaccggcat atggaaatga tatcaatctt gattttcggg 2268301 atttttgggt gcgccgcatt cggcggcttc tcccggcagc gtaccttatg atcttttcca 2268361 ctgttgtgtg ggtcgtattg tttgatcgag aactattgca cactgtacgt ggagatgcga 2268421 tctcttctct cttttatatg agcaattggt ggtttatttt tcacaagcta tcatattttg 2268481 atagtttcgg ttccccatca cctctaaaaa acctttggtc gctggcgatt gaagaacaat 2268541 tttatatcat atggccgatg tttttagttg ttggaatgta cataatgaaa agccgcgcca 2268601 gattggctgc ggtgatatca ttgcttgtgc tttgttcagc cgtgatgatg agcgtactgt 2268661 atgaacctgg cggagatccg agccgcgttt actatggcac agacactcgt tcgtttgaac 2268721 ttctcatcgg atgtgccttg gctttggtat ggccgatgaa aaggctgtct tccaacaggc 2268781 tgccaagcaa actgaagcac actttgcacg ccactgaatt tttggcattt tgtattttag 2268841 tgttgtgtgt ctatttcaca gatgaatacg agccttttct ttacagaggc ggaatgctat 2268901 tcattagcgt gactgccgca atccttattg catgtgtttg ccatccgagc agctttttag 2268961 gcaatctgct ttcatggagg ccgcttcggt ggcttggaac gaggtcttac ggaatttatc 2269021 tttggcacta ccctgttatt gtgttaagca cgccagttca agaaatcgga aaccctgttt 2269081 tttggcatat cgtgctaaag gtcattgtga catgtatact tgccgagctc tcctaccatt 2269141 ttattgagaa gccgatacgg acacagggat ttaggtcatt ttcccgccgt gtttttatac 2269201 atagaatcaa ggaatggaaa acgacatctg tcatcagcaa aatgtcaatt ggtttcatta 2269261 ttttcgctat acttattttt gcaggcgggc tgtcagggct agccggcgag caaaagcacc 2269321 ctaccaaatg gacctatagc tcacaagaaa caaatgctga caccagccag gcttctgggg 2269381 ataaaaagaa cgctgcagca gataaaaaac acaatcctga acaaaagaca acagattcca 2269441 atcagggtca aaaggaaaac aaagatagtg ggcaagagac tcataaaaag aaagacacgc 2269501 aatcccaaca gttgaaaaaa ccagcagaca ctgcgaaaga agttttagct ataggagatt 2269561 ccgtcatgct tgatatttct tcacacctgc gtcagtcatt ttcaaatgtg acgattgatg 2269621 gaaaggtagg gagacaaatg tctcaagctt tggaactcgc aagggaatac aagtctttta 2269681 atcagccgaa caaggctgtc atcattgagc ttggaaccaa tggctatttt acaaacagcc 2269741 aaatcgaaca actgcttcaa tctttctcaa aagctcatat ttatcttgtc aatacacggg 2269801 ttccccgcca atgggaaagc aaggtaaatg aatctttgca gcaacaggcc cacgcacatc 2269861 aaaatgttac gttagttgac tggcatacag aagctcttca gcatccggaa tattttaccc 2269921 ctgatggtgt tcacttggtt cctaaagggg caaaaacttt gactgctctt attgttcagg 2269981 cgatgaaatc gtaaaaaaga gatcctatac agatcacttt tttactttag tttctgatcg 2270041 ttgattatgt cttctttcag caaggcagcc cttatgttta catgccgttt acgtaagggt 2270101 aagccaaaat tgaatggagg gatgataatg aaaggaaatg aagaacatga catccaaaaa 2270161 gagttgaaac gatatgagct ttttttcaaa aaacgatata aggttcttta tacagtaaac 2270221 gattttatca tcggtgctat gtttctcgtt ggaagttttt tcttttttta tgaccggtta 2270281 atgtcggcag ggatatggct gtttgcgatc ggaagtttgc tgctgttaat caggccgacc 2270341 attcggctga ttcatgactt tcattaccgt aagcatgtgg aacagcaatt caagcatcaa 2270401 tcttcaacag atgactgatc ttaaggaata agaaagaaca aaatgccaaa agcctgagtc 2270461 gaaaatcaaa aacaagactt tcagactatt tatttttaaa aacaaggtaa aaagaactaa 2270521 acttttgcct ctgcatgccg atatgaataa taaggccggc gcgatactcc ctataacatc 2270581 cttttcagta gatttcatta tcgtgccggt tttctcatat gcaaagcaat cccgccaatc 2270641 agattggcgg gattttatat tttacattcc tgtccaaacg tctttcacat aacgtctttg 2270701 atcttgcagc ttttgcagcc atacagctga ttcttcctga cttgctgctt tttcagcttc 2270761 atatgccaat cgcaaagttc tctctacatc aggagccatt tgcgatccat caccgcatac 2270821 gtaaatatga gccccttttt caatgagtgt catcaatttc tgcgtatctt gcttgagcaa 2270881 gtgctggaca tatccttttg gttcgttttc gacgcgcgag tagcatcggc ggattgtgac 2270941 caaaccgtcc tgttccgctt gatccagctc ttctctgtaa aggtcgtcat ggtccgggcg 2271001 gcggcagccg aagtataaaa gtgcttcacc aagggtgctt ccttccttct tcaaaaccga 2271061 tcttgcctga ataaagcctc tgaatggcgc aattcctgtg cccggcccga ccataatcat 2271121 aggcgtttca ggatcattcg gcatctgaaa tccggactgc ggcgtacgaa tgaagcaagc 2271181 tgctgcatca cctgtattca attctgctaa ataattagag gcgacacccc ggtattcacc 2271241 tcggccgctc catgctgagg ctttcacaac tcctaccgtc atgctcacga tatttgcatg 2271301 aactttcggt gagcttgaaa tggaatagta tctcggtttt agtgatggca aaagtgctaa 2271361 aaaccgttca aacggcattt cgcaagcagg ataatcctct aaaaaatcaa gcatggtaag 2271421 acgttttgca agtacctgct ctttgtaaat gccatcatct gaaacgagct gttccagctc 2271481 tttttgatgc ggcggacaaa ctgtataaga ggccagctcc cgaagctgaa gccttgatgc 2271541 cggttcctgc agctctacat aggacgacaa taaatccact actttgattg gccgatccat 2271601 cggcagatga gccatatgag cgcttccgct tacttttatc acatgattgg actgcaaacc 2271661 gaatcggctg agaacccgct gaacaagctc cctgctgttc tttggcagga ttccgatatg 2271721 atcgccttct ttatatgttt taccagccgg aatttccaat tcaatatggc gggttgaacg 2271781 cgtgctggca gctgtctgga gttctcgatt ctctaacaca atcccttcaa acgcgccata 2271841 tgctttagca accggcgttt ccgtcgcttc actgagaaaa gtaatcgata atgaaggcct 2271901 gtcttctttc tgggctattt cgttaatatc aaatgcgtcc atcgtttcct tccagaagcg 2271961 gttttcccaa gactcgcggt ggctttcaaa atcatcggcg gcgtcacctt ccccaatcgc 2272021 tgttaaacgc gatgccccct ttgctttcat catgtcatca atcaggcggg gaatccgctg 2272081 atacgtgctg gcccagctcc ggtttccgca gccgaatacc gcataggaaa cacctttcaa 2272141 ttggccttcc tcaagctctt tcagccactc tacaaatccg gcagcattat caggcggcgc 2272201 cccattataa gaagccgtta caatgacgac tgccccttct tcagggagct tgccgatata 2272261 atcatcaagc ggagccgttt cagctgtaaa gcccatctgg cggccttgag cagccagttc 2272321 accggctatt ccctcagctg tcccaagatt tgaaccaaaa agaacaagta aaggtgtgcc 2272381 gtgtttaggt ttggtttctt ttggctttgt ttctgctttg atgtctgcct gttcttttct 2272441 ctgtacattg attgccgctg tttttcgcgg tttcacagta attttaaaat catccggctt 2272501 gatcgttaat gcttctttga tttttagttc gtagccagta tggtttatca attcaaaatg 2272561 ctttaataca agaccgagaa ccattgtcgc ttcttgaaga gcaaactgca tgccaataca 2272621 agcgcgctgt ccgtttccaa acggcttata cgcatggtga gggatacttg aaggatcctc 2272681 aaaccgttcc ggacggaaat cttccgcatc cggtccccaa gcgttttgat cccggtgcag 2272741 ttttggaatt aaaacagtga ctggctgccc tttgctgatc ggatattccc cgcctagaac 2272801 agtatcctcc ttcgcatata gagaaaaagc cggagctgtt ggatacagtc tgagggtttc 2272861 atttaaaacc atccgaatgt atttgagctg ctggatttgt ttatattcag gcgtgtcatc 2272921 cgttaacacg cgatccgctt cctcctgagc ttttttcagt ttttccggat gtgtaagcag 2272981 acaataaatc gcaaaggata gcaacccgct tgttgtctca tgtccagcaa ttaaaaatgt 2273041 gatgatttgg tatcgaatgt tttcgtcatc cagcgtttca cccgttactg gatctttggc 2273101 ataaagcatg agagacaaga gatccttaat gttttcatcc ggattcgcct ttcgctccgc 2273161 tatcattcta tcaaccaggg agttcatgac ttctatatcc ttttggaact gcagcttcgt 2273221 tttcaccatc attttatctt gcaggcccag tcttttcgat tgattcatcg cctcttttaa 2273281 ggcacggagc atactggtga taaacggatg ctgtgaatca cggtaaaagc tgttgaatcg 2273341 atagttaaac ccgcataacc caatcgtatc aagcgtcaga cgtgtcatat cgtccgctac 2273401 atcaatttct tcattagggt ttaaccggct ccacttttga atcagctggg ttgcgatatc 2273461 cagcatcata gaatgatagc ctttcatcgc tttttgacta aaactcggca gcaaaatgcg 2273521 gtgggctttt tgccagttcg gttcgtgcgt ccagcttgta aataagccat ctcccccgaa 2273581 ctcacgcacc ttttgcaagc ctttgccaag gttcttgtca aagcgttttt catcacacac 2273641 ttcagccaca agattgtggc cggacacaaa aacactggat actcccggaa aatcaaaacg 2273701 gaaaatcggt cccaattcat cagctatccg ccataaggat tgagaaagct gttctttttc 2273761 cagatgcgga agatttttta aaggtccgta tgttttgggc tgaggtattg cgcttgcctg 2273821 tttcattaac atctcccttt cctatttttg tgatgaatga agcttaatgg cgtcccagca 2273881 gcattgttcc aattcagtaa ttaaatcagt gtccatctct atatcacctg tttgaacgag 2273941 ctgatatatc ttgagaaacg cccctaatac aatcgcaatt aacacattag agggcaggct 2274001 gcgaatcacg ccttccgctt ttcccttatt aaaatagtca tcaagcattt gagtcagatt 2274061 ttctatcatt tttttgcttg tatgatttaa gtaatgagcg tcttttttgg tttcaagaaa 2274121 aaaaagcgca tagtcgctct ctttcgtaaa ctgaacgaga cagcaaaata cgtggtgaaa 2274181 gccttctctg acaggcaatt ctgaaacgtc ttgcttcagt ttttccgtaa atcgctggat 2274241 gctttcttga aacagtacgt taacgagtgt ttctttgctg tcaaaataac gatagatcgt 2274301 tcctgtccct acatgagcac gttcagctat cataggaata gtggtagcgt caaaacccct 2274361 ttccgtaaaa agtgagactg acgctttcat aatcatgtcg tatttactgc tggatgcgga 2274421 tatcatgtaa tctgacaacc tccgattcgt ttacggaatg aatattcatt ccttttgttc 2274481 acaaagaatg tctgccctgt ctgatatcac ctctttgttc tttcttctgt tataagttta 2274541 tatgaaaaaa acttttttta atataaagta tatgcaaaaa ataaaaaatt aagaaaatat 2274601 acccaaatcc taatacgagg atcttggata tatttcccga gaaatttttt atttaacagc 2274661 cacaatacat agacaggaag cacgcctgat aacagaaaga tccctgaaat gctggtcttt 2274721 cagcagttga atatacgttt tctctttttc accggtattt gtgtcaatac tgatataaaa 2274781 ccggccgtca atttgaagca ccctgtaaat ttctcttaat gcaagcctaa tatcggtgca 2274841 gctttgaacc gtatgtaaag aaaagacttt attaaaggta cggtcatcaa agggaatgtc 2274901 ctctggatag ccatgaaaaa cctccccgtt ccccatgttc tttcgattcg cacgtgatat 2274961 ctgtcttacc tttcgttttg aaggatcaat gctttttagg ctaccctttt ttagtttctt 2275021 ggttatgctt ttaaagacag tgccgtttcc aattccaatt tctaaaattc tgtcattttc 2275081 ttgtatatct atagagtcaa tcatcatatg ctcaattgtt ttggttagct tatatttccg 2275141 agaaaataat ttccaaaaat ccgatcgttt atagagtcta ttttctagca ttttaaacac 2275201 ctgcttttgg tttcctatgt ttatttatta tcttaaaaaa ataaacatca tcttcatttc 2275261 taaaagtgaa ggaaggtacc aactagacgg caatgtattg aaaaatgttt caatagaact 2275321 aaactttttc atttttttcc gaaaaaaaag cagaaaacat aatgttttct gccctctttc 2275381 taatgccaat gataagggaa tacatacagc ctttgctgct gcattgccat cagcctctgc 2275441 tgtcggaatg gatttccata accatgtttg aaggaatgcg gcatggacgc ataaccatgg 2275501 ccaatcgacg gcagtctttt ttgataatcg ttcatcatgc catcacctgc ctcacaataa 2275561 cgttgattta ctatatgcag gcgcgcattt tcttgacagc tatttcgcta aacttggtcc 2275621 ttctccattg tataatgcat caatagttcc attctaagca tatgccattc ccccttcagt 2275681 ttttttcgtt gcttttagcg ccagtttgtt aaataaagat gctttaactg agactctttc 2275741 atttcatcat aaatttgttc aatctgctgt tctcgttcga attcttccag gcttttaaac 2275801 cgttttttaa tcgttaacgt taaaaagaat aggttaatcg tcatatcgct cacccccttt 2275861 caaagtccgc atcaagcgaa ataacccgcg gcacaaccct tctgccgcgg gcaaataaaa 2275921 accgcagaca aaagaagaca ccaatgcctc tactgcctgc ggggagttgc gtatgtccga 2275981 ctattccgaa tttaatgcgt gcgataagca tcggttaagg aaggacacga actcttccac 2276041 aggctgaata aaccatgaac ttttacatgt gtatcacgta caggttgacg tcgttgtctc 2276101 attgtcattt tggttcagcc tcctttgctt ttttcttact ttgtaagtat atccaccaaa 2276161 ttccattttg taaacatctt tttctaaaaa tggacggaaa ttgtgcaaat catcgaatgg 2276221 atttgcccgt tggtcatgac acctgcttca tttcttttct ggagcggtct ttcttatgat 2276281 atgcaataaa ataaatgaga ccgacaaata cagctccgcc gatgacatta ccgataaaag 2276341 ccggaatgat gtttccgatg aactgccccc acgtgaatga gcctgcaaaa atggcagcag 2276401 gaatcacaaa catgttggcg acaacgtgct gaaatccgat agccacaaaa gccatgattg 2276461 ggaaccagat gccaaggatt tttcctgctg cgtcttgggc gccgaaagaa agccacactg 2276521 caagacatac aagccagtta cagccgatgg cggaaatgag aaccttgcca aagctcatat 2276581 caagctttcc ttgggcaacg gcaatcgttt tttctaaata aggacctgtt tcagtcaatc 2276641 caaccaaatg cccgaaaaag taagcaacaa acaatgcgcc gattaagttc ataattgtga 2276701 cgattcccca gttaatcgct aactctttta ctgatatttt tctcgaaaat aacgccatcg 2276761 caactgacat catattgcct gtgatcagtt cagcgccagc gagaacgaca aggatcaggc 2276821 cgactggaaa tactgctgca ccaatcaaac tggacaggct cccccattct ttcggaagat 2276881 cgccaattac cctgatatca agcaaatacc caagcgcgat aaatgcaccg cctaaaaacc 2276941 ccagcacaag cagtgacggc agcgggagct ttattttttt catccctgct tcaattgctg 2277001 cttccgctat ttcatccggt tttcgaaaag ccataataaa acgcctccat tacttcttct 2277061 tttctcacag ttatgcaaga aaggcaataa aaaaggcagc actcaaataa cctgtgtcaa 2277121 accaggcgtt tgaatgctgc ctaacttgta tgcataccca tacaacaata tcaagcagta 2277181 tataagatat tgaaagagaa tatatacagt tcgtgcatac attccattgc tttagccttc 2277241 tataactgta gcaacatcat atcaaatgtg acaaatttgt gtcaatgaca aatatactag 2277301 ctttgcagag cttctttttg ctcatctatt tttcggtcaa aaacaaatac agatacagcg 2277361 atgttttcct caattttaat atcagaaaac aaatggacta gcttagctcc cataagttcc 2277421 tccattcctt ccggtgtttg tttggaataa aggtcttgaa ttaggcttgt ccgggccgca 2277481 tgtaccatct ctcttccttc aggcgtgcgg gcaataaact gctcgcttgc actcagattt 2277541 ccgtatagtg ttgaaactgc catgttttct acaaatacag tatgaattct ctcaggccct 2277601 tttccgaaca attctttgcg aagttttcga ataatatcat tgaattcatg aattttttta 2277661 gacatgctga ttaccccttc cgatattgcc ttataaaggc ttttcccggt tcccctcagg 2277721 acatttcact tggttaaaat tttcctgcca tattgtatta taataaatat cacattataa 2277781 taaaagcagt gttgatggat ttgtaatagg atcttgttat gagtctatcg ttttataaaa 2277841 atcaaggatt ggtctgttag taagacttgc tagtgaacta ttccgccatg tgtgtttaca 2277901 ccttcttaga attaagggca ggtgtatcta tacatggctt tttttgactt cttgaaagaa 2277961 agatggaggg gaatatgaat atgatggacg ttaagtcgat cagtgtccgt gtagacggaa 2278021 cagaaattca agcacgagca ggggccacaa ttttagatat tttaaatgaa aacggaattg 2278081 agtacccgca gatttgccac gtaccagagg ttgacccgat tcaaacttgt gatacttgca 2278141 tagtagaggc aaacggcaag ctggttcgtt catgcgcgac ggttgcagaa aacgggatgt 2278201 ctattgatct ttcaggaaat cgagtgaaag aagcgcaaac cgaagcgatg gaccgccttc 2278261 ttgaaaatca tttgctgtat tgtacagttt gcgataacaa caatggaaac tgtacgctgc 2278321 ataatacagc ggaaatgatg gggatcgagc atcaaaaata cccatacacg ccaaaagaag 2278381 atccttcttg cgcggttgat atgtctcatc ctttttaccg ctatgatcca aaccaatgta 2278441 ttgcctgcgg ccagtgtgtt gaggtctgtc aaaaccttca ggtaaatgaa acactctcaa 2278501 tcgactggga acgcgaacgc cctcgcgtca tttgggatga gggagttccg atcaatgaat 2278561 cttcctgtgt cagctgcggt cagtgtgtaa cagtatgtcc atgtaatgca ctgatggaaa 2278621 aatcaatgct cgggcaggct ggttttatga caggcattaa agaggacgtc atggaaccga 2278681 tgattgatct cgtgaaaaat gttgaaccgg ggtatggcag catttttgcc atttctgaag 2278741 tcgaagcggc aatgcgtgaa acgagaacga aaaaaacgaa aactgtatgt acgttctgcg 2278801 gtgtcggatg ttcatttgaa gtatggacaa aaggacggga tattttaaag atccagcctg 2278861 tttctgatgc tccggttaac gcaatttcca catgtgtcaa agggaaattc ggctgggatt 2278921 ttgtcaattc aaaagagcgg atcacaaagc ctttaatccg taaaaacgga gcctttgtgg 2278981 aatcttcttg ggaagaagcc ctcgatcttg tcgcaagcag attaggatca attaaagagc 2279041 agtacggtaa aggctctgta gggtttattt cttcttctaa aattacgaat gaagaaaact 2279101 acgtcattca aaaactagcg cgtcaggtat ttgaaacaaa caacgtcgat aactgctcac 2279161 gctactgcca gtctcctgct acagacggat tgttccgcac tgtcggcatg ggcggtgacg 2279221 ccggcacgat taaagatatt gccaaagcag gcctggtcat cattgtcggt gccaatccgg 2279281 cggaaggaca cccagtgctc gcaacacgcg tcaaacgggc acacaagctc cacggtcaaa 2279341 aactgattgt tgctgacctg cgtaaaaatg agatggctga gcgatctgat ctgttcatca 2279401 gccctaaaca aggcacagac caagtttggc tgatggctgt tacgaaatat atgatcgacc 2279461 aaggctggca cgatcaggcg tttattgatg agaacgtcaa ttactttgaa gattataaag 2279521 aaacccttaa aacgtatacg cttgattatg cagaacgcat cacaggcctt tcaaaagaaa 2279581 acatcattca aattgctgaa atgattcgtg atgctgacgg cacttgtgtc ctttggggaa 2279641 tgggtgtcac acaaaataca ggcggttctg atacatcagc agccatttca aacctgcttc 2279701 tcgctacggg caactatcgc cgtccaggtg ccggcgctta tcctctgcgc ggacacaata 2279761 acgtgcaagg cgcatgtgat atgggaacat tgcctggctg gctgccggga tatcagcata 2279821 ttacagatga caaagcacgc gctaaatttg aagaggcata tggtgtcgag attgatggaa 2279881 agcctggttt agataatatt caaatgcttc atgccattga agaaggaaaa atgaaagcta 2279941 tgtatcttgt cggtgaggat atggcactgg tcgattcaaa cgcgaaccat gtgcatgata 2280001 ttttatcaag ccttgatttc ttcgtggtac aggacatctt cctgtcaaga acagctcaat 2280061 atgctgatgt cgtcttgccg gccactcctt cacttgaaaa agacggaaca tttaccaaca 2280121 cagaacgccg tgtccagcga ttgtatcagg cgcttccgac gcttggtgac gcaaaaccgg 2280181 actggtggat tattcaagag gtggcaaacc gtttaggagc gaattggaat tacagccatc 2280241 caagtgacat tttctctgaa atggcgagtc tttctcctct gtttgccaaa gcaagctatg 2280301 aggtgcttga aggctggaac agcttcctat ggggcagctt cacaggtgaa agcacaccgc 2280361 ttctgtatga agacggattt aatttccctg acaaaaaagc ccgctttgcc ctttctgatt 2280421 ggaccgagcc agcggcattt ccggaggaat atgaccttca tatcaataac ggccggatgc 2280481 tggagcattt ccacgaagga aacatgacaa ataaatcgaa aggcatccaa gcgaaagtgc 2280541 cgaatgtatt cgttgagatc tcacctgagc ttgcacaaga gcgaggtgtt tgtgacggtt 2280601 cgcttgtacg gctcgtttct ccgttcggag cagtcaaatt gaacgcgctg atcacagacc 2280661 gggtacggaa aaatgaactc tatttgccaa tgaactcgac agacaaggag tcagcgatta 2280721 acttcttgac gggccctgca gctgataaac ggacgaacac gcctgcttat aaacagacaa 2280781 aggtccgcat ggaagtgctt ggcggctgtg aaacagcgcc gcttccaaaa acaaatccgc 2280841 gcaacaaaaa acggcatccg caaaacggag tcgaagcaga aagaaaatgg aaccgccctg 2280901 gctatgtaca tctgactgat taaacgatag gaggaaaacg aatggccact ccgattacga 2280961 cgatcaaaaa agaaacaaaa acagctgagc aaattaagct tgaaaaaata gaagaactga 2281021 aagagctgct ggcggaaaat gaggacgccg tctctaaaac gatgacgtta atgaatgaac 2281081 tcaatgatct tggaattttt gatgcggcaa caagcatgct cagagcgaag gaagacattg 2281141 ccaagattgc gcttggccaa gtttcccgcg agcctgtcac caacctcatc aacacgatga 2281201 tggccgccgg aggcgcattg acaaaagccg atcctgagtt tacagcaaag cttttagaaa 2281261 gcgtaatggc tgggactgaa caggcacaaa gctttttaaa agaagacaag aaagtcggga 2281321 ttctcgacct gttaaaagca atgaacgatc ctgacatcaa cagagccgtc gggttcggcc 2281381 ttcagttttt aaaaggcatg ggaaaagaac ttcgagaaca ataacagaaa aacagccatc 2281441 tctgatgatg gctgtttttt tattcgtcgg cttcttccag acgcttcttg taaataagtg 2281501 aacggtcagc gcaaaagaag gcaccggcta aaaatacgca atccgctaaa aacatcgtcg 2281561 atttctggcc taatgttaag ccttgatcag ggagaactgc gcctatatat aaaaaagtgc 2281621 tgactgcaag caatgtaaaa gcaaaatgct tgtagtcttc ttttaaagat ttcattctat 2281681 ttttgttcaa aagaatcacc tgccagattc atagtatacg actattataa tataatccgg 2281741 cggcttacag agaaagtaat tctatccatt tgttatatat tttcaagcgc ttggccgata 2281801 tcttccaaca agtcttccgc atcttcaatt cctacagaaa ttctgatcaa gccgtccgta 2281861 atgccgagct caagccggcg ttctctcgga atagaggcat gtgtcattct tgcaggaaca 2281921 gaaattaagc tttcaaccgc ccccaggctt tcagcaatgg taaacagttt cagatttcct 2281981 aaaaacgcat caacccgttc ttcactgcca atatcaaagg agatcatgcc gccgaagccc 2282041 gctccttgcg tttttgcaag ctcatgtccg ggatgatttg aagaaccagg gtaatataac 2282101 gtttggacag cagggtgatt ctcaagaaag cttgcgattt tccgcgcatt ttgatcgatc 2282161 gcttccattc tgagtcccaa cgttttgatt cctctcatta acagccagga atcttgaggg 2282221 ccgagcacgc cgcctgtgga gttttgcaca aaatgcagct cttctccaag ctctttcgaa 2282281 gctgtcacaa ctaaacctcc gacgacatca ctgtgtccgc caagatattt tgtcgcactg 2282341 tgcagtacga tatcagcgcc taaagtaagc ggctgttgaa aataaggagt attaaaggta 2282401 ttgtctacga taagcagaac acccgctttt tttgcgatat cagccatgag cgtcaggtcg 2282461 gtgattttga gcaacgggtt tgtcggtgtt tcaatataaa ttgcttttgt attagggcga 2282521 atcgcttttt caacttcttc cctgctgctc gtatcaacaa atgttgattc aatgccaaga 2282581 cggttaagca cctttgtcat cacgcgatat gttccgccgt acacatcatc agtcaacacg 2282641 acatgatctc cgctgttaaa cagcatcata accgctgtaa tggcagccat tcctgagctg 2282701 aacgcatagc ctgcttcccc gctttccagt tctgtcacaa gtgcttcgag agcggttcga 2282761 gtcggattgg ccgttcttga atactcgtag cctgtatgct gccctgcttt cggctgcttg 2282821 tacgtgctta cttgataaat cggcacggaa actgcgcctg ttttctcatc acctgtgatt 2282881 ccgccatgta tcatcaatgt ttttttcttc atatcagatg cctccttcgt atatttgttt 2282941 gctgatatat cgatcgctgc tgtcaggaaa tactgtgaca atgttagttc cagcggatgc 2283001 ttttttcgct tcctccaatg ccgcataaag cgctgcacct gaagagcttc cgatcagcag 2283061 gccttctttt tctgccgctt ctttcacaag tctaaacgca ttctcatctg ttacggtgta 2283121 gatctcgtca aaatggctct tatccatata atcggggata aactccatgc cgatgccctc 2283181 tgttttatga gcgtggggct ctcctccgtt taaaatcgag cccaccggtt caacaatcac 2283241 cgttttgact gctggatttt tttcttttaa gaaggaagct gtccctgcga atgtgcctcc 2283301 tgatcctgcc cctgcgacaa atgtatgaat attcccgtca agcgcttccc acatttcagg 2283361 tccaagcgtc ttatagtaag tcgatggatt tactcggttt ttaaattgca aaacgcaata 2283421 agaattttca atttcagtct ccagctgaat ggctttttga atggctccct gcattccgtc 2283481 ttgacgcggt gtatgaatga ttgatgcgcc aagcgcttgc ataatttgct gtttctctct 2283541 gctgaaatgt tcagggacac agaaaatcgc tttcagccca tattttctgg cacttaacgc 2283601 aaggccgatc cctgtattgc ctgccgtagc ttctataatc actccgccgg gtttcacttt 2283661 gcctgaatcg agcgcgtcac gaatcagcat atctcccagt ctgtctttga tgcttccccc 2283721 tggattcatc atttcaagct tggcatacac cgcgactcct tctggaacat caaagttctt 2283781 caagcggaga agcggtgtat tcccaatcag ctcggtaatg tccgtaatca ctgtcatata 2283841 tgtcctcctc cttaatagag gttgttttta gagaaaaacg gaggagaacg ttctccccgt 2283901 tttaatgaat tcgtttgatc acctttaaca caagctctgt tgaatgaaca gccgcctgct 2283961 ctaaaaattg gtcaaatgaa acatgtgatt ctttgcctgc gatatctgat aacgctctga 2284021 tgacgacaaa cggcgtttta aattgatggc atacttgagc cactgccgca gcctccattt 2284081 caaccgcgta cagatcagaa aatctcgcac gcacctcttc aacccgcttc ggatcgttca 2284141 tgaaagaatc gcctgttgca atcgttcctt ttgcaacctg aatgccgtcg agttcagata 2284201 ccgcttcttc agtgatgctg atcagctttt catccgccgc ataagcagcc ggaagacccg 2284261 gcacttggcc gtattcatag tcaaaagccg ttacgtctac atcatggtgg cgaacgtcag 2284321 tggaaatgac gacatcccct acattcaatg tatgatgaaa tccgccggct gagcctgtgt 2284381 taatgacata atcaggcttg taacggtcaa gcagaagcgt cgtgctgata gcagcattta 2284441 cttttccaat tcctgatttt aaaagaatca cttcagttcc ttcatattcg cctgttgtaa 2284501 attcacagtg tgcgatcgtt tctgtttttg cattttcaag tttgtttctt aagatggtaa 2284561 cttcctcttc cattgctccg atgactgcta gtctcatcta ttcacattcc cttcacttta 2284621 ccgtttgatc gcctccatta tccacacgaa gtcgttttgc tgagtgaatc ggactgcaaa 2284681 accttcagct gtaaacattt ctttcaacgc atccaatgta ggataatgct ctgtctctaa 2284741 atcatttgca agctgataaa agccttgaga acgggcttta tcgatagcct gttgatacgc 2284801 ttgcgcattt tcaaagacgg tatcggcaaa cactatttta tcatgcaagt gaaggtattt 2284861 gccatattgc tttatggcag cccgcttttc ttcgtcagtc aaatgatgaa aagcatatga 2284921 actgacaatc gtatcagcct gaaatggcgg ctcagggaat gtcaggaagt ctccatcaac 2284981 gatttccgtc ctgcctgaga gcttgtcaga agccagttta cgcattgctg gagaaggttc 2285041 gattccaaat acagttttgc ctgcatcgag cagcttagct gtcaaattcc cggtccccgg 2285101 gccaaattct aacacatgcg ttccagattt tctgacgatg gcatcaagga tatgatcgta 2285161 gcctctgaac gcttctttat actgaatatc taaaccttgt actgtttgat cataagttgc 2285221 tgcccaatct tcaaagagag ggataaattc acggcccata tttgtcacac tccatattta 2285281 ataattccta taagtatact atggattaat gatggaacag ttcctataat accacatatt 2285341 ctgaaaagca ggtactaaaa cactttgtgt attttatgcc atctcatatt gcgcattgac 2285401 cgcaaaaaag cttatacttc atatgacttg tgaaagctgg agggtcaaga catgaatttt 2285461 caattagatc tgattaaaga caaagtggaa ttttttgaag cggcttcatt gcaggagctt 2285521 gaaaagaaaa tcaatacaca aattgaaaac aataaagcca tcatgctccg ggtgaaatct 2285581 gtttcacacc aaactcttgt ggcagaagga agaatattgt acagcgcggt ggttcatttc 2285641 tcagctgaag cctaaaacaa aagcagccgg ttttaacccg gctgcttttg tttattttag 2285701 cttttctact tttgtcggct tccagccttt ttcatcgacc catgtaatcg tgacttgata 2285761 tttattccca gtcgccttgt ccaaaatctt gcctttggca tcctgagggc tgccgttatt 2285821 tccaagccag agcaccgtca tgttatctgt tgagacacca gttgcgtacg aaatggcttt 2285881 cagcatctca gcccagtctt gtgagcttga atcataagta gcggcatgct cgccagtctg 2285941 ctcagttccg actgctttcc agtcaggatt ttcatacgtt ttttccacat cgctcgatga 2286001 gccgccttct gttacttttg catctttaag cccgtcaccg gctgaatctg agcttgaatc 2286061 tgaatcagag tcatcttttt tagaagaaga atcatctttt ttggaatcag agtcagaaga 2286121 cttctcagaa tccttttcgc tgtcagatgt atctttcttg ctgtctttta tatcctcatc 2286181 cgatttcttt tccgtctttc ctgaagccgg agattcctgt ttttgcgccg tttcagaatc 2286241 cttgctgaca tctttgctag aaggactgtt aatgaagaga ttcgctgcta ctacgacaat 2286301 tagtatggat acgattgcga ttaaaatgtt aagcactaaa ttggcttttc tgcgtttatc 2286361 acgattttca taacgagatt gattattgct caataattct gcactccttt atccctcttg 2286421 gctcagcata tattttaaca tgtgctgaga agttgttcta tttctgattg atttcaattt 2286481 cgtgtacttt tttaacaata tcataaaaca ccgaatttgt cagagcctta tctcccggtg 2286541 tatccatgtg taaaacaact agagcgtatt tcggcttatc cgcgggaaaa tatccggcaa 2286601 accatttttc gtagagcgtt tccttctctt ttgaaagctt gcctgtctgg gctgtgcccg 2286661 acttccctgc tacagtatac ggaagatctt gaaaccttct gcccgttccg gaaggagatt 2286721 ctactacccg ccgcagtatt ttttgaagct gctgtgacgt atatttgtct atcgtttccc 2286781 ctttgagctt ctgatcttta aacgtaacga gcgttgtgcc gttcttatac tcaatttgtt 2286841 cggcaatttt cacctgccgt ttttctccgc cgcgggcgat tgtcgccatc atattggcta 2286901 cctccagcgg cgttaccttt acatttttct gcccgattgc tgtttgcgca atggcttttt 2286961 tgactgattt gtctttttca tccccccaaa tcacgccgct tttttcgtta tacagctggc 2287021 ggaaatcggt ttcgtggtac agttttccct cccagcctgc ccgatcagtg agagccagct 2287081 tctcggacat atcttcaata accgagctgt cttttttcat taattgttct gcaagactcg 2287141 taaatgtgta attacagctt tgggcaaaac tttcatcaaa agacaaggtg cctttgtcgt 2287201 cccccggttc cccgtacagg tttaaattgc aattaaaggt ttgactaggc ttcaccatat 2287261 tattttcgat tgcagctgcg gcaatgactg ttttaaaaac tgatccggga tagattggcg 2287321 tcagcatata attttgaagt gtgttttgcc gggacacgtc tgcatctggt ttgcttacaa 2287381 ttcccagaac actgctattt tcgatgtcca gcagcacagc tcctcccttt ttcagcccct 2287441 gttcatccaa tacctcctcc atcgcttttt gaatgctttg atcgatcgtt gttttgatct 2287501 ggagcggata aaatgtattg gcttcagctg tatatttgac gtccatgcca aacaaagggt 2287561 ttccttttcc gtccacatga tataaaagct ttgtgtcttg ttccggaagc aaaaactcgt 2287621 caaatgtccg ttctaaaccg gttgttccga tttctgttgt aatcggaagg ctctccttgt 2287681 caggatattt cttgcgaagc agcgccggat cttggttcgt gctccctatc gtatgtgaag 2287741 caaggctggg cttgtcttca ttctccatat atacgccgta aatgccggga tatttcaaag 2287801 aattgatttt tgtgatagat tgttttgaaa gtgttttgat tttcttttgc tgcaaaatga 2287861 ccggtttttt tgcctgacct agtgtctggc gcaaatcatc ttcagacatg ccgaggatgt 2287921 ccgcaacttt tttgatcggc caatcctgcg tcagcagaaa agggaacaaa acaaccgcag 2287981 gctcgctttg tcctgtcagc gcccgcccgt ttcgatctaa aaaagagcct cttccatctg 2288041 aaatgagcac ttcctccgtc cgctgtttca cactttcttg aatcaaatta attttctttt 2288101 tagaaaatga ttctgtgaaa aacagctgga tttctgcaag tctcagcaga agcagaaaaa 2288161 atacaatcaa aaaagcgatg actgccagct tcattcgttt cgatatcttc ataaaaaaac 2288221 acctcaccca cattgtggac gaggtgtttc gctgctaaac agatattatg aaattttcac 2288281 aattttcacg agcatttctc cgcccggtgt ttgtactgtg acttcttcat ctactttttt 2288341 gcccaagagg ctttttgcga tcggtgaatc gtttgagatt ttcccttcaa acgggtcagc 2288401 ttccgcgctt ccgacgatcg tatatgattc ttcatcaccg tcaggcagtt cgacgaaagt 2288461 gacggtttta cccaaaccga caacgttaga gccgccgtca tcttcaatga ttttcgcatt 2288521 gcgaatcata ttttcaagag tcgtcacgcg gccctctaca aatgcctgct cttctttcgc 2288581 tgaatcgtat tcagagttct cggaaaggtc tccgaagctt ctcgcaattt tgattcgctc 2288641 tactacttct tttcgtttaa ccgttttcaa atattctaat tcttgttcaa gtttttgttt 2288701 tccttctgca gtcataggaa aaactttctc ttgtgccatg tcccttcact ccttctggtt 2288761 gtccctcaac atcttcgatt atgtatgaga gcataaacta aaaaatacaa gaatgagaac 2288821 acagggcagt cctcgttctt ctctcccata taggtactgt ttatcttaaa ctgaatcgtg 2288881 tcgttctgca aatatttcgc gtttataaac agggaaagaa gggaattcgc acattccctt 2288941 cctgcctata cataatatgg tcagagttat ttatgtctat gctatggtat tacaaaatcg 2289001 cgttttgttc aagaatggtt tgaatttttg tgaccatcag atcaattgcg acgtgattct 2289061 gaccgccttc cgggataata atatcagcgt atcgtttcgt cggctcgacg aattggttat 2289121 gcatcggacg gaccactgac acatattgtt caatgacaga atcaatagag cgtccgcgct 2289181 cattaatatc tctcataatc cgtctgatga tacgcaagtc agcgtccgta tcaacataaa 2289241 gcttgatatc catcagatca cgaagccttt tgtcttcaag aacaagaatg ccttcaagga 2289301 taataacatc ctttggctct acgtgaaccg tttcttctga acgtgtgtga agcttatagt 2289361 cataaatcgg cttttcaatc gggcggtaat tcaatagatc ttgaatatgc tcgattaaat 2289421 agtcattatc aaacgcaagc ggatgatcat agtttgtgtt cagcctttct tcaaacggaa 2289481 gatggctttg gtctttataa taaaggtcct gctggatcat taaaattgag tgtcctttaa 2289541 actgttcata aatggaccgt gtgacactcg tttttcctga accggaacct cctgcgattc 2289601 caatgactac tggattctta cccatgggct gttacttccc ctttctcatc atgttgctcg 2289661 gataaatctt tttgtctagt ttgaatttga caatttgcag gggatggcgg gcagcatcta 2289721 gctcatttcc gtcttcgtcc caaatggttt caatcgtatg tgtaaagttt tcgatttctg 2289781 gaccgaaaaa ttccacttcg tcgccttttt tgaagaaatt gcgctgctga agcgtgacca 2289841 tttgtgtatc ttcatcataa ttcagcacta agccgacaaa atcatatgtc gttttcttgg 2289901 cgtgttcgcc gaacatttgc tcttcatagc ctggcgttcc ttcaaagaaa gctgtcgcag 2289961 tgtccctgtt ggcgcactta tcaagctctt caagccattc tttttgaatc acaaagtttt 2290021 ctggatcagc gcaataagca tcgattactt tgcggtatac gctgacaaca gttgctacat 2290081 agtgaatgga tttcatgcgg ccttcaatct ttaagctgtc gatccccatt tcaatcattt 2290141 ttggaatgga ttcaatcagc ttcaaatctt tcgggctcat cgcaaatggt gcatcttctt 2290201 caccatacaa agcaacggcg ttggcaccgt ctgtttggta gagatcataa tcccagcggc 2290261 atgactggca gcagcctccg cggttggaat cccgcgctgt catgtgattg ctcagcacgc 2290321 agcggccgga atatgcaata cacattgcgc catgaatgaa ggattcgatt tcgatatcta 2290381 ccttttcttt catttctctg atttcaagag cgctagtttc acgtgccagc acgacgcggt 2290441 cgagaccttc ttccttccag aactggacag ccttccagtt tgaaagagac tgctgtgtgc 2290501 tcaagtgaac ctcaacattc ggcgccactc tgcggcatgt ttcaataata agcggatctg 2290561 ccacaataat accggcaacg ttggcgtctc caagcgcttt taaatagtct tcaagcccgt 2290621 ccatgttttc attatgagcg aaaatattcg ttgttacgta gatcttcgcg ccatatttct 2290681 ttgcgaattc aacgccttct gcaatttctt cgatcgtaaa gttatcggca ttcgagcgaa 2290741 gcccgtattc ctgtcccccg ataaagaccg cgtccgctcc gtaatgaaca gcgattttca 2290801 gcttttcaag attacccgca ggtgcgagaa gctccggctt tttcgtaatc acacgctttc 2290861 cattaacgat tgtggatatt ttatcattta cggcagtcat agcttaacct ccttttgatt 2290921 aataaaccgt ttccttgaag aagaatccgg tatcaatttt tctgtttact ggctggatgc 2290981 tttcaatgcg ttcgatccag tcttcttttt tcgcttcgta ttcgtcacgg ttttccacgc 2291041 acaaatcaat tgcttctctg tacattttgg tgacttctat taggtattca ggcattttca 2291101 aaacaccatc gattttgaaa gaatcaattc cggcatctat caattcctcg agctcatcaa 2291161 tgatgcacac atcgttcggg ctcatgatgt gagtgccgtt ttcatcttcg aaaatcggat 2291221 atttattatc gcgttcttta tcgtgtaaaa acatgcctga ttcttttttc tttctttcaa 2291281 tgtccatgac tttgccctga tattcaaaat agtttccaat caaagaacgc ttcgattgga 2291341 acatgcacgt cattccatgc acctggattt caatttcgac ttcagcattt tctttaatct 2291401 caacaatgct gtccatgttt aattctctgg caagcacaga acgcgccgca cccttgcgtc 2291461 cccagtagtt gcatgtataa tagttggtgc ctgtcgtttc tgtgctccaa tgaagcttca 2291521 gatcaggcgc agattcacgg gcagccatca gcacggcagg atcgccgaat accgctgcat 2291581 cgacaccggc ttctgctaag aaagccagat attcgccaag ctcacccact ttatcattat 2291641 ggaaaattgc atttacagca acgtatactt ttgccccttc tttgtgagca atctctacgg 2291701 cttttgttac atcttcacga gaaaattctc cggctaatct caagccgtat ctctgttccc 2291761 caactaaaaa cgcagttgcc ccagcctgta tgagcggcaa aatgtccgct gtactcgtcg 2291821 gcgtcactaa gagctctggt tttttcatga cgttcacctc ttctttttac taatcgcaag 2291881 tccgtccccg acaggaataa tcgcagtttg ataatccgga tgattcatca gccaatgatt 2291941 atattcatca attttggcta caagcctgcg ccttctcttc ggttctattt tgctgtaatc 2292001 ctctgccacc agacctttaa acagcacgtt gtctgttata atcaccccgt ccggtgaaag 2292061 catcggttca tataaatgaa aaaagttttg atactgacct tttgcagcgt caataaaaat 2292121 gacatcgtaa ggcgcggtta catgaacggc gtcggctaat tcaagcgcat ctccgtaaaa 2292181 aacatgaatc cggtcatcaa gctgaaattc cttgatattg tttaccgctt cttcatgccg 2292241 tttctcattg cgttcaattg tatatatttc agcagacggc agttccagag ccattcgaat 2292301 ggctgaataa ccaatggccg ttccgatttc tagtattttt ttcggctgtt tcacagacaa 2292361 aatttgaagc agcacctcca tgcccgcttt ttccataatc gggacatgat gttcttctgc 2292421 atatgcttca agtctcttca cgttatccgg ccgaggcttt aataatgctt ctatatagtc 2292481 atttatttgt tcataccggt cagtcactac aaacagcctc ccgttctaaa aaggagtgcc 2292541 ccagtcttat gcgcaggaca ctctctgaat acatcatgat acatcggtaa acaacccgat 2292601 atattttatc ataaaacctt gcggaaagcg aacaaaagga gagctttttg ctctcctttt 2292661 atttctcatt ttttgaggaa atgtattttt cttttgcttt attatgctct tttagcgttt 2292721 ttgtaaatac gacctcacca tttgatttgg ccaagaaata cagatagtcc gttttatccg 2292781 gatgcagcgc tgcttcccat gatgacatgc cggcattggc aatcggccct ggcgtcagcc 2292841 ctgtgttttt atacgtattg tatggtgaat cgatttccag atccttataa agaacccgat 2292901 ctttatgctt gcctgccgcg tacaggacgg tcggatctgt ttggagcggc attttctttt 2292961 tcaggcggtt ataaaagacg ctcgcaattt tatggcggtc ggctttttca gtcgcttctt 2293021 cttctatcaa agaagccatt gtcagcagct tatgcacaga aactttgttt ttcttcattt 2293081 ctgatttata tgtttccaca taagaatttg tctgcttaat cattgccttg ataatgtctt 2293141 caagtgatgt gtccggatcg ttaaaagggt atgtagccgg gaataggtac ccttcaagcg 2293201 ggtgcttaat gtttttattg aaaacatcat ttgtcacagt gtccgggaat tctttcttca 2293261 gctgattgat aaatgtttca tcgtccagct tcgctatgac ttgtttttta gagtattttg 2293321 tttcatcagc aatagcagcc gcgatttggg tcagctgtgc tccctcagtc actgtgattt 2293381 gaaaagcgta acctgtagcc ccgcttgtca gcttctgaat aatggcatct aaatccatac 2293441 ctttattcag atggtagaat ccggcctgaa acccggaagc acctttatat ttcacatagt 2293501 actgaaacgc cttctcgctt tttatgacat catttttctt taatatcgat gcgatggctg 2293561 aaacagacga accgctcgga atgttaatat taactgtcgt tttactgtct ttttcaacag 2293621 gttcaagcaa tgatttccca tataaaaatg ccccgccaat gatgagaaac agcacaacaa 2293681 tggaagacag tatgattctt tttttattaa aaaacgattt tttttgctga ttgatataca 2293741 ttaggtctcc tcccatcagc tcttatacta catgattcat tgtatttcgg caatttatta 2293801 caaaaagagg cctgcataaa gcagaaaaaa gccggagcag tatagctccg gctttggttt 2293861 ggcgcgatgt tttactcttc gtcttcgtcc gctaagaatg tgtttagtgt ttcttcgatc 2293921 atatcccatt cttcgtcagt ttcaatcggg aatagctcac cgttttcacc gtcttcgttt 2293981 ggcgtgaagc tggaagcaag aatttctact tcttcgtcat cttttgattc gattggatag 2294041 tacaagacat aagatttgcc aaactcttca ttttcaaatg taaacagcac ttcacaaagc 2294101 tgttcatttc cttgatcgtc aacaattgta atattttttt cgccgtgttc cattttcttc 2294161 acctctggct ttaatttaag ctgtcaagat atccttgtaa aatcataaca gccgccattt 2294221 tatcaatgac tttttttcgt ttttgcctgc tgacgtcagc tgcaatcagc attttttcag 2294281 ccgccattgt ggtaagacgc tcgtcccaca gcacaacagg aacattgtac gttgtttcaa 2294341 gcactttcgc aaatgtttgg ctggcttcgc ctctcgggcc gactgttccg ttcatgttct 2294401 taggaaagcc gagcacgatt ttatctatag tatagtcctt tatcagttca gataaacggg 2294461 ataaaccata atcgccttct gcttcattta tctttatggt ctcaatgcct tgagcagtcc 2294521 agcccatttc atcgctcaga gctacaccga gtgttttggt tcctaaatcg agtcctaata 2294581 ttctcattct ttatttacgc ctctttatgc tgttctaaat aagactttac caattcctcg 2294641 attaattcgt ctctttcaag tttgcgaatt aaattgcgag cgtcacgatg cctaggaata 2294701 taagcgggat cacctgacag caagtatccg acaatctggt tgattggatt gtagcccttt 2294761 tcctgaagcg cgtcatacac tgtaatcagc acctcattta cgttagtctc agcagaatca 2294821 tcggagaaat taaatttcat cgttttatca aacgagctca ccgttttgca cctctttccc 2294881 aaattcgcag gcaaagttca gcctggggtc ctaatcttac catcattcta cactacatgg 2294941 gcgaattata aaacggattt cacccaatct tctacagaag ccaaagcttc ttctaatttt 2295001 tccggctgtt taccgcctgc ctgcgccatg tccggacggc ctccgccgcc tccgccgcaa 2295061 acttccgcag cttgtttaac cagcttgccg gcgtgaagtc ctttctcaat gaggtccttt 2295121 gtgactccgg cagagatatt aactttatcg ttttgtaccg caccaagcac gatcaccgca 2295181 gagccaagct ttgctttgag ttcatcgacc atagtgcgga gatgattcat gtcttttgca 2295241 tttacttttg ccgcaagcac gtttacgccg tcaacttctt ttactttcga caggattgct 2295301 cctgcttcca cgttgcctag ttttgcaaga agagattcat tttctctttg tgcatccttc 2295361 agttcagcct gcagagccgc gacccgtttc ggcacttctt tgatatttgt tttcagctcg 2295421 tcagcggtct gcttcaatac agaaatctgg ctgttcattt cgacgtaagc gccttgtccc 2295481 gttacagctt caatccgtct tgtgcctgct ccgattccgg attcagaaac gattttaaac 2295541 aagccgattt ctgctgtatt tctgacgtgg cagccgccgc acagctctaa gctgtaatct 2295601 ccaacttgaa cgacacggac aatatcgcca tatttttcgc cgaacagtgc catcgcaccc 2295661 atttcttttg cttcagcgat cggtttcaaa tcaatgctga ccgggatgct cgcccagatc 2295721 ttttcgttta cgattctttc aatttgttcg agctcttctt ttgtcacttg gccaaagtgc 2295781 gagaagtcaa aacgaaggcg gttttccgtt acaagagagc ccgcctgatt gacatgagtt 2295841 ccaagaacat cttttagagc ctgatgcaat aaatgcgttg ccgtgtggtt tttaatgacg 2295901 ccgcttctca tatggtcttc aacttcagcc gtaacatgca ggcctttttg aacagtaccg 2295961 ctctccacaa caccttcatg cacatgctgg ccgttcggcg ctttttgaac atctttaatt 2296021 cttacaactg cctgctcgct tcggagatag cctttgtcgc cgatttggcc gccgctttct 2296081 gcatagaacg gtgtttcatc aagaatgatt tgaacgcttt ctccttcatg agcctcttcg 2296141 attaattggc cgtcctgaag aagcacaatg atattggcat cagctttggt ttgagagtag 2296201 ccgacaaatg tgctttcaac tgtcacgtcg cgcagtgcgc cgccctgcac ctgcatgctg 2296261 ccgacatcct ggcgggcgtt tcttgcccgt tcacgctgct ggttcatttc ctcctcaaag 2296321 ccctcatggt caaccgtcat gttctcgtct tctgcgtatt cttcagtcaa ttcaaccggg 2296381 aatccatacg tatcatacag tttaaacaca tcagcacctg agataacgct gctgcccttg 2296441 tctttttctt ttttgatcat ttctgacagg atcgcaagcc cttcattaag ggtctcatgg 2296501 aagcgttctt cctcggtttt aatgactttt gcgatgaaat ccgctttctc tttcacttca 2296561 ggatagaaat cagccatgat ttctgcgaca accggcacta aatcaaacat gaacggacga 2296621 tggatgttga tcgttttggc ataacgcacg gcacggcgta ataagcgtct taatacatag 2296681 ccgcggcctt catttgacgg cagcgcaccg tcactgacag caaaggcaac cgttctgata 2296741 tggtcagcaa tcactttaaa cgcagtgtct ttcacattgt ctttgccata tgtttcacca 2296801 gaaatcgatt ctgttgcttt aatgatcgga acaaacaaat cggtgtcaaa gtttgtcgga 2296861 acattctgga tgacagacac cattctttca agacccatgc ctgtatcaat atttttcttt 2296921 ggaagcggtg tgtacgtgcc gtcagggtta tggttgaact ctgagaacac aaggttccat 2296981 acttccaggt aacggtcgtt ttccccgcct gggtaaagct ccggatcttc tggatcatta 2297041 ccgtatgctt caccgcggtc gtaaaagatt tccgtattcg gtccgctcgg cccttcaccg 2297101 atatcccaga agttcccttc cagacggata attctttctt caggaatacc gatttttttc 2297161 gcccaaaact catatgcctc ttcatcttca ggatgaaccg taacagagag aagctctttg 2297221 tcgaagccaa tccacttgtc gctcgttaaa aactcccaag cccatgtaat ggcttcttct 2297281 ttgaaataat cgccgatgga aaagtttccg agcatttcaa agaaagtgtg atggcgcgca 2297341 gttttaccta cattttctat atcgtttgtt ctgatcgctt tttgagcgtt tacgattctt 2297401 ggattttccg gcacgacacg gccgtcaaaa tattttttca gcgtcgcaac accgctgttg 2297461 atccaaagca gtgaaggatc ctcatgaggc actaatgacg cgcttggctc taccgcatgt 2297521 cctttttctt taaagaaatc caaaaacatt tgacgcactt ccgcagaagt taagtgtttc 2297581 attgtatttc ctcctctata aaaatcgaaa ttctcttcag tgacagcaaa aaagccctcc 2297641 ccctatgcaa accaacgttt acacagggac gagagctgtc tcgcggtacc accctgatta 2297701 cgggcattca tgcgcccgtc acctttaacc ctgtaacgca ggataagcgg cagtgattaa 2297761 ctgcactcag gattagcttc ctccgatctt ctgataaagc tcctttcagc ttatggagct 2297821 tctctcttta acagggcttc ggcgtactca gatccgtcac tcgagattcg tatgtattct 2297881 acgagaaatt atagacaagc ggcacgccga tgtcaatgct ccgtcctcat ccgcaaaaaa 2297941 tggatcatca ttacttttaa aacagccgtc gcaggaacag ccagaatcat cccgacgata 2298001 cccgcaagct cccctccggc aaggagtgca agcatgataa cgaccggatg cattttaagg 2298061 cttctgccga caatgaacgg actgaggata tttccttcca taaactgcag aataaacacc 2298121 gtaatcacca caacaagaac cgccttgact gagatcgtca tcgcaattaa caacgcagga 2298181 acagctccga tgaaagggcc aaaatacggg atgacattcg ttaccccaga gataaggcca 2298241 agtatcagcg gatacggaag cccaaatacc cagaacgaaa tgcctgcaat cacgccaaga 2298301 atcaagcaga ccaaaagctg gccgcggata taatcgccaa gcgaatcatc cacatcccgc 2298361 aaaaaggcgc tgccccgctt tctccacgac ttcggagtca agtaccatac tgtctttttc 2298421 attaactcaa tgtccttcac catataaaac acgagaaaag ggattgttgc agcaattaag 2298481 aagtaatcaa gcacattgcg gatcccgctg atcgcaccct cgatcgttcc cgcaaaaaac 2298541 gcctccgtct ggcggatcat tttatctata cggtgatgca taccatcagg ccagtcatcc 2298601 gtatggttat gcacatgaag aagaagcccg ttatacgttt cggcaaacat gggtatattt 2298661 tctgacaaat ccgtcagctg cacgattaaa acaggcaccc ctttatacaa cgcccagcca 2298721 atcccgccaa aaaaaagaac ataaatgacc aagatgctca aagtcctagg caatcctttg 2298781 ccatgcagcc attctgtgac cggaagcaat aaataagata taaaaataga aatgatcaag 2298841 ggaataaaga tcgtttttat gacgagccaa aagggtgacc ataacatatc aagcataaaa 2298901 aagacataga ctgttaacag aaccagcaaa caaatagcca cccacaacaa aagctgcacc 2298961 ggtttttgga gcatctgctt tcacctcacc tatatctttt gaggtttaca aggaattatt 2299021 ctttatgttt ctttagtcag tcagaagtca tggacatttt ttcactttta attttcagaa 2299081 aagtttgatc atttactttt tggtcaaatt ttctgatagg aggattgcga tgatcacatt 2299141 tcaaaatgta aacaagcatt acggagattt tcacgtgtta aaacaaatta atcttcaaat 2299201 cgaaaaaggt gaagtcgttg ttatcatcgg cccatccggt tccggtaaaa gcacattgct 2299261 cagatgcatc aacagacttg agtcgatcaa tgagggagtg cttacagtaa acggcaccgc 2299321 cattaacgac agaaaaactg atatcaatca agtgcggcaa aatatcggga tggtgtttca 2299381 gcactttcat ttatatccgc ataaaacagt gctgcagaac atcatgctgg ctccggtaaa 2299441 agtgcttaga caatcacctg aacaagcaaa ggaaacggcg cggtactatc ttgaaaaagt 2299501 cggcatccca gacaaggctg acgcctatcc ttcccagctt tccggcgggc agcagcagcg 2299561 tgttgccatc gcaagaggac tggcgatgaa gccggaggtc atgctgtttg acgagccgac 2299621 atcagcactt gatcctgaaa tgatcggtga ggtgctagat gtcatgaaaa cactcgccaa 2299681 agaaggcatg acaatggttg tcgtgacaca cgaaatgggg tttgccaaag aagttgccga 2299741 ccggattgtc ttcattgacg aaggaaaaat tttagaagaa gcagtgccgg ctgaatttta 2299801 cgcgaacccg aaggaagaac gggcccgctt attcttaagc cgtattttaa atcattaaaa 2299861 cagaaatggg ggagcttgta tgaaaaagat tttttcttta gcattgattt ctttattcgc 2299921 tgtcatcttg cttgccgctt gcggcagcaa gggatcaaac ggagaagcct caaaggagag 2299981 caaaaaagat acgctagccg ccattaaaga caatgacaaa attgtcttcg gcgtaaaaac 2300041 ggacactcga ctgttcggtc ttaaaaatcc aagctcaggt gagattgagg gttttgatat 2300101 tgatattgct aaacaaatcg ctaaagacat tttaggtgat gagaaaaaag ctcaatttaa 2300161 agaggtcacc tcaaaaacaa ggattcctat gctgcaaaac ggggatatcg acgccattgt 2300221 cgccacaatg acgatcactg aagaacgaaa aaaggaagtt gacttttctg atgtctattt 2300281 cgaggccggg caatcgcttc tcgtgaaaaa aggcagcaaa atcaagagtg tcgagaatct 2300341 tggcaaaggc tcaaaagttc ttgcagtaaa aggctccacc tcctctcaaa acattcgtga 2300401 aaaggcgcct gaagcatctg ttttagaatt tgaaaactac gcagaagcct ttacagccct 2300461 taaatcgggg caaggcgatg ccctcaccac agataatgca attttatatg gaatggctga 2300521 tgaaaataaa aattatcaat taacaggaaa gccttttaca gatgagcctt acgggatcgc 2300581 cgtgaaaaaa gggcaatctg ctctcgcgaa agaaatcaac gcttcactta aaaagatgaa 2300641 gtcggatggc agatacgatg aaatttataa aaaatggatc aaagaagacc cagctgaata 2300701 acaaccatcc cgggatgagc aggcgatgct catcccaatt tgataaggag tgaataggca 2300761 gatgaatgtg tcaattcttt tcgataactt cagcatgtat atggacggtt tttaccatac 2300821 cttgctcgca agtgttatcg cgctggccgg cagttttgtc ctcggcgttg ctgtagcggt 2300881 tatgagaata acagtcttta agccgctgca atggctcggg accgcatatg tagaattcat 2300941 ccgcaacatc cctcttcttt taattacctt tgttttctat ttcggacttc caaacgcagg 2301001 cctgaggctt gacggttttc aagcgggaac ggttgctctc accatttata cctctgcgtt 2301061 tatcgctgaa gccatcagag caggcatcca gtctgtttca aaagggcaga tggaagcggc 2301121 acgctcgtca ggctttacct acagccaagc catgctccat atcattttgc cgcaggcaat 2301181 caaaatcgtc attccgcctt taggcaatca atttttaaac ttagtcaaaa actcttcgat 2301241 tcttggggtt gtggccggat tggatcttat gtaccaagcc gatttagttt cgtcgagcac 2301301 actcgttgta tttgatgttt atatttttgt ggcgcttttt tacttagtgc tgacgattcc 2301361 gcttagcatc ggtgttaact atctggaaaa acggctggaa aaaagctatt gataaggagt 2301421 gagttacatt ggatttcatc ggtgcttatt cacaggagca tttagcgttt ttatgggatg 2301481 gctttctcgt caccttgtac gttgctttca tctccatcat tctgagcttt ttcttcggtt 2301541 taatcgcagg caccctgcgt tatgcgaaag ttcccgttct ttctcaattg attgcagttc 2301601 tcgttgaaac gatcagaaac ctccccttgc tgttaattat tttctttacg ttttttgccc 2301661 ttccggaaat tgggattaag cttgaaatta cagctgctgc aattacagca ctaacgattt 2301721 ttgaatccgc tatgctatct gaaattatcc gaagcggact gaaatcaatt gacaaaggac 2301781 aaattgaagc ggcgcgctcc tccgggctga gctatacaca gaccctgttc tttatcgtta 2301841 tgccgcaagc gcttcgccgc atggttccgc ccatcgtaag ccagtttatt tctttattaa 2301901 aagatacatc gctcgctgtt gtgatcgccc tgcctgaact gattcacaac gcgcaaatta 2301961 ttaacggcca aagcgctgac ggcagttatt ttttcccgat ctttttactt gcggccctta 2302021 tgtatttcgc agtcaactac agcctttcac tcgcagcaag acgcctcgag gtccggcaaa 2302081 catagaaaag gatactcttt ggagagtatc ctttttgcat taaaacattt tcgtaattct 2302141 tcttctcatc cgcttcatgc ttcgattatt cagcatgtca gattgagtcg ccattcggta 2302201 cacgagagct ccggctccca ttgccaaaag agaagtcatc gtccgattca tcctgcgcat 2302261 ctcctttcat gattaaaaat tgatgctgcg ttcatcctca gaaaacaaat catccaagct 2302321 gcttaacgtt ccgtcttctt ccacctgatg agttgcaatc ttccctttcg ccactgtcag 2302381 ttcaataaaa cagccccagc aataatattg gttcacgccg attttgccga tatccttact 2302441 tttgcaattc gggcatataa gcatacctca cacctctatc cgttcagaac gatctcgtct 2302501 ttccgcacct cgacaagcga atccgctctt tggatctggc gcttgcttcc cgccaggtca 2302561 gaaaagaaac cgtccgagag ttcatatgct acgattatgc ccctgtccaa acaaaagtat 2302621 acatcttcca gcatccccaa tatatccccc tcttgcgatt tcacaagctt catcttcatc 2302681 tgctcgtatg tgaagcatga tttcggaaga ggcaaaagct gttctgaact gaccgaagcc 2302741 aatatgcggt catcaaaaat ggaagagata tcacacgccc gtaatagcgc atgatgatga 2302801 tgcaaaaagc gtttttgtgc aagaataaac ccaagacaat ctcctttcag agaaaaacaa 2302861 atatcggaaa ttgtcccgag ataactagaa gttcgttctg agtatactgg gaatccttct 2302921 acttcatggc atgttctcaa agtgtgatca accacctttt gttgaacagg cttaggtttt 2302981 gctttgcgcc ttagactcat acgatgaaat caattccact gcaaatgaaa aaaaactccc 2303041 gcttgcacgg gagcatttta ttgctgttct tctttcataa aatcgaatgg tgtaatgcct 2303101 tccatgccaa tgttggcgtc gtgtacgctg aacgggagct ctttttgcaa agcttcaagc 2303161 tcggcatcca tttcctcaac ctgtacggac agcctgtttt tcaaggaggt ctgtctgaca 2303221 gttgcatcat tatttttcac gccccactcc agcgcctcct cttccccgca taaaatgaga 2303281 aatttcttcg ctcttgtaat cgcggtataa agaaggtttc ttctgagcat tctataatag 2303341 cctttcacaa caggcaaaac cacaatcgga aattcacttc cctgcgattt atgaatagaa 2303401 cagcaatacg catgggtaaa ttgattaaaa tcttttttcg taaatgtcat ttcattgccg 2303461 tcaaaagaaa cgacggccat gtcttctttt tctgtatttt cctttgcata aaatatcgac 2303521 gtgatttcgc caatatctcc gttgaacaca ttgttttccg gctgattgac aagctgcaaa 2303581 attttatctc cggttctgta gacaacatcc ccgaacttca attctctccg tttttcttta 2303641 ggaggattta aaatgtcctg cagcatcaca ttcaattcat taatgccggc ttttcctctg 2303701 tacatcggag cgaggacctg aatgtccttt gctgtatagc cttttttcaa tgcattggcg 2303761 acaaccttct caactacttc tttgatttgc gacccgccgc agcgaataaa ggaacggtcc 2303821 tttgtcgggg cagtcaaatt gttcggcagc aatccatttt tcatctggtg ggcaagctcg 2303881 acgattgatg acccttctgc ctggcgatag atgtctgtca gtctcacagt cggaatcacc 2303941 tgggatgcca gcaggtctct gagcacttgt cccggaccga cggaaggcag ctggtcttcg 2304001 tctccgacaa tgatgatttg tatatgatca gggatcgcct tgaacaaatg attcgccagc 2304061 catatatcaa gcatactggc ttcatcgata attaacagct tcccttcgat cggctgatcc 2304121 tctgtatgag taaagccttc agcgccgttc cagccaagca gcctgtgtat cgtaactgca 2304181 gggagtcccg ttgattcact catccgtttt gctgctctcc ctgtcggagc ggccaaaaca 2304241 atcggaaaag cttcatcctt tttataagct gacgggtcta gtgacacacc gtgaagctct 2304301 ccgtagagct cgacaatccc tctgattacc gtcgtttttc ctgttcccgg gccgcctgtt 2304361 aaaagaagca tcggcgagga aagggctttt tgaatcgctt ccttctggct gggggcatac 2304421 tgaacgtcca tccgttcttc cagttctccc aacgcgagca aaaactctga ttcgggaaac 2304481 tggttctcat attcggtttg gctagcgata tgtttcacac gctttgcaac gttttgttct 2304541 gcgtaaaaca gcgaaggaaa ataacagcgg ccatcttcta tgacaatgtc tttattttct 2304601 ccaagggcaa taattgcgtt agcggcatcc atttctgtaa tgcgctgccc ttcccttgct 2304661 gactggttta acagtgattg agtgtcgatg atcagctgtt ccgtttctat gtacgtgtgc 2304721 ccctctgaca gacaagtcgt ttcaagcgtg tacaaaatag cagcttttac ccgctcagga 2304781 tgattacccg aaagacccat tctgctgccc agctcatccg cttttccaaa cccgatgcct 2304841 tctacatcct tcacaagctg ataaggattt tcctgaatct tttcaagcgt ctcggattca 2304901 taggcttgat agattttcat agacagctgc gggccaaagc caaactgatt caaggaaatc 2304961 atgatttgct ccagtccctg atgccgctgc aatgcgccag ccagcgtgtc tgctttcttt 2305021 tttgagagtc tgggaacatc ataaagcact gaagcatcag ccaatatttt attaatggcg 2305081 ctgtcgccca gctttttcac aatttcttca gctgtttttt tgccgatccc ctcgaataaa 2305141 tcactcgata aatattgaat gatgccttcc ttagtcgttg gaatctcctt tttgaaatgc 2305201 tccgcctgaa attggagccc gaattttgga tgggttacga tctttccgta aaacgtgtag 2305261 gtctcttctt cttgaagcgc agggaagtag cccgtcacgg atacggcttt atcttcaatg 2305321 gcttcggagg tctctgtgac tttcactttc agaaccgtat ataaattggt gtcattatga 2305381 tagatgactg tgttgactgt cccttttaaa tagggctctt cctccagttt aagctgatcc 2305441 ggatgctgct gcacgagctg tccctcctcc tgtgcctgtt atgatggatc aatcagtttt 2305501 ttagcatgaa gcgcaagcat atgatctggc tggatatcga ttgccttgtc cagcatttcc 2305561 agcgcttttt ctcggttttc tttataagca taagtgacac cggcattata aaatgcatct 2305621 gcatgccccg ggtcttgctc tgtcacagct gcgaattggc tgagcgcttc gtccagcatg 2305681 ccctcgttgg ctaagcacat cccgaattga aaacgcgctt ccgtatcgtt ttcattcagt 2305741 tcgactgctc tttgtaaata tggcagtgca agcttaggct gttcgagctt gacaagtacc 2305801 gttccgagca tgtaaaacag gtcgccgttt tccatccccg cacgtagcgc tttttcaaac 2305861 atgtctttcg cttctttgta catttctttt acaacataga catttcctgc tccataataa 2305921 gcagtggctg cgctactgtc taattcaagc gctttatcat aaaacgcaag cgcacgttcc 2305981 agctcgttta cggatgaaag aaggttggca aaattgatat acggaatcgc gtcttcttta 2306041 ttttcttcaa tcgcttttgt aaatgcctct gccgctttct cgtaatcgcc ttcctgcatc 2306101 gcctctatac cgagttgatt ataatccacc gatcatcttc ctttcattaa aaaaccccaa 2306161 ctcagtgttg aggtttttca tcttttatac gtaccacaat tttgttccgt ctttgtacac 2306221 atcatcaatt gtcccgccgc caaggcattc ttcgccgtca tagaagacaa cggcttgtcc 2306281 cggcgttaca gcgcggactt gttcatcaaa gatgacttcc gcttcacctt cgccagtcat 2306341 gcgcactgtt actttatgat cctcttggcg gtaacggaat ttagccgtgc aggaaatctc 2306401 ttcgcccttc atgatatccg aacgtaccca gctgatattt gttgctgtga ttttgtcgga 2306461 atataaaagc gggttatgga acccttgatc tacgtagagg atgttctttt caagatcttt 2306521 gcctaccgca aaccacggct cgccgcttcc gccgatgcca aggccgtgac gctgtccgat 2306581 cgtatagtac atcaacccgt cgtggcggcc ttttacttcg ccgtccatcg tcatcatatc 2306641 gcccggctgt gcagggagat attggctgag aaacgttttg aagttgcgtt cgccgataaa 2306701 gcagatgcct gtactgtctt ttttcgtcgc tgttgcaagt tctgcttctt tggcaatttc 2306761 acgcacacgg cttttttgaa gttcgccgat cgggaacatg actttgctca gcgtatcttc 2306821 tgtcagctga ttcaggaagt acgtttgatc cttgttttca tcaatgccgc gcagcattct 2306881 gacttttccg ccgcttctgt ctactcttgc atagtggcca gtcgctaaat agtcggcgcc 2306941 aagtgacaat gcatgctcca aaaaggcctt gaatttaatt tctttgttgc acaatacatc 2307001 cgggtttggt gttctgcctg ctttatattc atcaaggaag tattgaaata ccttctcata 2307061 atattgcttt tcaaagttta cggcataata cggaattccg atttggttgc agacgcggat 2307121 cacatcttca taatcctctg tcgccgtgca aaaaccgttt tcgtccgtat catcccagtt 2307181 tttcataaag attccgatta catcatagcc ctgttctttt aacagcaggg ccgccacaga 2307241 tgagtctact ccgccggaca tgccgacgac gactcttgta tcctccggcc gtttttccat 2307301 ttcattcact ccaattacta cgccgcctta ttatgtcagc cgtttgacaa cgtcggccac 2307361 atgtttggca gcagttttca cttgctcagc cgtattgccg aggccgaagc tgattcgaat 2307421 agaggacgtc agccggtcac tctcttcgcc gaacatagca gtcagaacat gtgacggcag 2307481 gactgaaccg gccgtgcacg ctgaaccgct ggagacagcg acaccagcca tatcaagatt 2307541 aaccagcagc gcttccactg acacaccggg gaaataaaga ttcagaacat gcggcagact 2307601 atgctctttg tccccgttga cctcgaatgc cacacctgca tctctaagcg tgtcggcaaa 2307661 gattgcttta aacgattgat acttctcgtt tttttcgtca cgttcttcac ttgacagctt 2307721 gatcgcttct ttcagcccga caatgcctgg aacattttcc gttccggcac ggcgttttct 2307781 ttcttgctct cctccgaata aaaggggtga aagcttcaca tctttactag catataaaaa 2307841 gcctgtccct tttggcccgt tgagcttgtg cccggaaaca gacagaaggt caatatggct 2307901 gtttttcaca tcaattggca gcaacccgaa tgcctgaaca gcatcggtat gaaaataagc 2307961 tttgtgttcc tttaacagct caccgatttc ttcgatcggc tgcactgttc cgacttcatt 2308021 atttccatac atcactgtca caaggattgt atcatcacgc agtgcttctt tcacctgttt 2308081 tgcactgact cttccatttt ggtcaacgtc cagatacgtt atgtcaaatc cgtctccctc 2308141 aagtttttca catgtgtgaa gcacggcgtg atgctcaatt tttgttgtga tgatatgtct 2308201 gccaagatct tttcttgcaa gtgcggttcc catgatcgcc aagttatcag cttccgttcc 2308261 cccgcttgta aaaatgatct cctgctctgc cgctccgatt tctgctgcga tctgcgctct 2308321 tgcttcatcc acccattttc gagattctct gccaaatgaa tgaatactgg agggattacc 2308381 gaaactgccg gagaagtgcg gtatcatttg ttccagcacg cgctcatcca tcggagacgt 2308441 tgcggcatga tctaaataaa tccgttccat tatgtttaca cctctgatct aaatatagaa 2308501 catataagct tcttgctctc cgtctgtata gctggcaaga tcctctaatg ttgtactgtc 2308561 taaaacctct tttacagcat cccggatgcg aatccagagc tcacgcttgg caggctcctc 2308621 atcttccagc acttcaacag ggctgatcgg cccctcaagc acacggataa tatctcccgc 2308681 agtaatggca tccggctcac tgcctaatac atatccgcca tatgcgcctc tgatgctttt 2308741 cactaaaccg gcatttctga gcggcgatac cagctgctcc aaataatgct cggacaaatt 2308801 attcgtctgt gcgatgcttt ttaatgaagt cgggccttca ccgtgctttt ttgcaagctc 2308861 gatcataatg gtgagcccgt atcttccctt agttgatatt ttcaacatga acacctctgt 2308921 tatttcatga ttttccacat ttataatggt aatttctata tgtttcgtcc gtttattatc 2308981 ttatagacca actgttatta taacatacct tcagcgaatt ttcattgagg cagaaggaaa 2309041 ggggccttta cccttttcta atgtacggtt ttccgttacc ctgtaattaa gtaaggagag 2309101 atgatagatg aagccattgg catatcggat gcgtccgaca aaaatagagg atattatcgg 2309161 ccagcagcat ctggtggctg aagataaaat tattggcaga atggtccagg caaaacattt 2309221 gtcatccatg attttgtacg ggccgcccgg aattggaaaa acatcaatcg caacagcaat 2309281 cgccggttca acaagtattg cttttcgaaa gctgaatgct gtcattaaca ataaaaaaga 2309341 tatggaaatc gtagctcagg aagccaagat gtccggccaa gtgattttga ttctggatga 2309401 agtccacagg ctggataaag gaaaacagga ttttctatta ccctatttag aaaacggaat 2309461 gatcattttg atcggagcaa cgacggctaa cccgtatcat gccattaatc cggcgatcag 2309521 aagccggacc cagatttttg agcttgaacc gttaacacct gaactgatta aacaggcact 2309581 ggaacgtgcg ctccatgatg agcatcgggg ccttggcacc tattctgtat ccattgatga 2309641 tcaggcgatg gagcattttg cccacggatg cggaggagat gtccgctccg ctttaaatgc 2309701 gcttgagctt gccgtgttgt caacgaagga gtcagcagac ggtgaaattc acattacatt 2309761 agaaaccgcg gaagaatgct tgcagaaaaa aagcttttct cacgataaag atggtgacgc 2309821 gcattatgat gtactgtccg cttttcaaaa atcaatccgc ggctctgatg ccaacgctgc 2309881 tcttcactat ttggctagat taattgaagc cggtgatctg gagagcatcg caagacgatt 2309941 gcttgttatc gcctatgagg atatcggttt agcaagcccg caagccggcc ctagagtgct 2310001 gaacgctatt cagaccgctg agcgagtcgg gtttcctgaa gcgcgaatcc cgctggccaa 2310061 cgcagttatt gagctttgcc tctcaccgaa atcaaactct gccattctgg caatcgatga 2310121 ggccctggca gatatcagag ccggaaaaat tggggatgtc ccgaagcatt taaaagacgc 2310181 gcattataaa ggagctcagg aattaggaag aggaatcgac tataaatacc cgcacaatta 2310241 cgacaacggt tgggtcgaac aacaatacct ccctgatcct ctgaaaaata agcaatacta 2310301 taagccgaaa cagactggaa agttcgaatc tgccttaaag caggtgtacg ataaattaat 2310361 gaaaagaaaa taaaacaaaa aaacagcctt gatcatcaag gctgttttta tgcattattt 2310421 atccttcaca cgtttgattt caatgtcttt caaaagatcc atgacaacat gtccgcccat 2310481 aatcaaacct gcaactgacg gcacaaaagc attagaggaa ggcggcattt ttgctttacg 2310541 tattttcgct tcgtcattcc ccacttcttt tctgacatct tcccgaataa caatcgggct 2310601 ttcatcagag aaaatcactt gaacgccttt tttgataccc tccttgcgta atttcgtacg 2310661 aacgaccttc gcaattggat cagtgtgcgt ttttgagata tcagcgattt ggaagcgtgt 2310721 cggatccgtt ttatttgcag cacccatgct ggagatgagc ggaatatccc gttttagaca 2310781 ttctttcatt aaatgaattt tataacaaat ggtgtctgac gcatcaatga catagtcaag 2310841 accatagtca aaaaactgct catacgtttc ctccgtatag aacattttta acgcgatcac 2310901 ttcacactcc gggttaatgt ctgcgatccg cgccttcatt aaatcaactt tcggctgtcc 2310961 gacagttgaa agcagcgcgt gaagctgacg atttacattt gtaatgtcga catcatcttt 2311021 gtcgacaagc agaatgcggc cgacgcctga ccgcgcgaga gcttccgccg cgaacgaccc 2311081 gactcccccg actccaagca cagcaactgt gctgtttttc agcgtttcaa ggccttcttt 2311141 tccgatagct aattcattgc gtgaaaactg gtgtaacaag aacctcactc cacattcgta 2311201 ttctggtttc atctataaaa tggctgatcc atgagcagcc gttttttctg cgcacaaaaa 2311261 ataaagtccc aatagtgccg ttgcagcttt cctttgtttt gaacccgctc tcagcaggtg 2311321 ggtgccctct tttaaatctt gtaagtcctc tttaccgaat gaaaagaggc atgtacgcca 2311381 tttaaaaatg cgggctccca aatcaaaaaa atgttcggtc aaaactaggt gtacaactaa 2311441 cacatcagga ctttatttaa cttgtcaaaa tcatatcaca gacgattttg attttcaaga 2311501 atcgaactgc aaattcagtt cttaactttt ttcttgatag aaagatgaag ctcgtcaagc 2311561 tgggcgtcgc ttacttcgcc tggcgcttct gtcatcaggc agcttgcact tgccgttttc 2311621 gggaatgcaa tcgtatctct caggttcgta cgtccagcga gaagcataac gagacggtct 2311681 aagccgagtg cgattccgcc gtgcggagga gcgccgtatt caaatgcttc cagcaggaat 2311741 ccgaactgtt cagccgcttc ttctggtgag aagccgagaa gcgcaaacat tttttcctga 2311801 atatcctttt cgaaaatacg gattgaaccg ccgccaagct catagccgtt taagacgagg 2311861 tcataagctt gcgctttcat gtcttcaggc gctgtttcaa tcagctcaag gtcttctcgg 2311921 acaggcattg tgaacggatg gtgcgctgcg taaaaacggc cttcttccgg atcatgctct 2311981 aatagcggcc agtcgatgac ccataagaaa ttgaacaatt tttcgtcaat cagtccgcgt 2312041 tctttcccaa gctttaagcg cagggcgccg agtgatgcgg ccacaacttc gaattgatcc 2312101 gctccgaaca gcagcaaatc accttcagca gcatcaagtg cttcaatcag cttagactgc 2312161 ttttcttcat caaagaattt agcgatcggg cctttcactc cgtctgcctc aaccttcacc 2312221 caggcaagcc cttttgcccc gtagtttgca gcaaaagcgc caagagcgtc gatgtctttt 2312281 ctggagtaat cgccggcacc gccttttaca ttgatggctt tgaccacgcc gccgtttgct 2312341 acagctgatg agaacacttt aaattccgta tcctttacaa tgtcagacac atccgtcaaa 2312401 agcatgtcaa aacgcgtatc cggtttatca gacccgtact tgttcattgc ttcgtcatac 2312461 gtcattcgag gaagaggaag ctgaagttcc tcaccttttg tttcacgcat aacctttgcc 2312521 atcatctcct cagccaatga cataatgtct tcctggctca taaaggacat ttcaatatca 2312581 atttgcgtaa actcaggctg acggtccgca cgcaagtctt catcgcggaa acagcgggca 2312641 atttgataat atcgttcaat gcctgatacc atcagaagct gtttaaatag ctgcggagac 2312701 tgcggcagcg cgtagaactc accttcgtgc acacggctcg gcaccaagta gtcacgtgcg 2312761 ccttcaggcg tgcttcctgt taaaatcggc gtttcaatat caagaaaccc attttcatct 2312821 aaaaagctgc gaacagcttt cgtcacgtta tggcgcagct gcatcgtctg gaacatagcc 2312881 ggtctgcgca aatctaagta acggtgtttt aaacgaacgt cctctgacac ttcttcagct 2312941 tgatcagaaa tcgcaaatgg aggtgtcttt gcagcattta atacgttcac tccatcagca 2313001 tgtatttcga tcgcgcctgt tttcaaattc ggattaactg ttccctcttc acgcgccacc 2313061 acttttcctt gaatatcaag cacgtattca tttctgatgc cttccgcaat agcaagcgct 2313121 tcttttgaca catcagggtt aaaaacgact tgaacaatgc ccgtacggtc acgcaagtca 2313181 ataaaaatca atccgccgag gtctcgtctt ttttggaccc agcctttcag cgttacagat 2313241 tcgccaattg ctttttcagt tatatcaccg caataatatg ttcttccaaa caatgcgttt 2313301 cactccttat cccttttggt ttgccttcat cacatgtata aattcatcaa gtgccacttc 2313361 aatctgttcg cccgtctgtg catcctttac attgattttg ttttgggcaa gctcatcttc 2313421 acccaaaatc gcaataaatc tggcctttaa gcgatcagct gttttaaact ggcctttcat 2313481 tttcttattt tcataatcga tttcactgga aatgcctgct tctctcagtt tgtacaccaa 2313541 tgaaacagaa taatcctttg ctttttcgcc gagtgtgacg atatagcagt cgattccctt 2313601 atcaacaggc agctctcttt tttcagcatc aattgcggca agcaagcgtt cgatgctcat 2313661 cgcaaatccg atgcccggtg cttcaggtcc gccgatctgt tcgacaagcc cgtcgtagcg 2313721 tccgccgccg gcaagtgtcg taatcgcgcc aaagccctcc gcattgctca taatttcaaa 2313781 tgcggtgtgg ttgtaataat ccagccctct cacaaggttc ggatcgattt catacgaaat 2313841 gccaagatca tttaagtatt gtttcacttt ttcaaaataa gcggctgatt cttcatttaa 2313901 atatgtcaaa atcgaaggtg ccgatttcat cagctcatga tcacggtctt ttttgcagtc 2313961 caaaattcta agcgggttcg tgtgcagccg ggactggcag tctgaacaaa attcttcgat 2314021 gcgaggctcg aagtgtttca cgagcgcttc tctgtagctt ttgcggctat cttgatcgcc 2314081 gagactgttt atgacaagct taacgttttc taaacctgct ttttcataaa tactcatcgc 2314141 aagcgccatt acttcagcgt cgattgcagg gtctttcgaa ccaatcgctt caattccaaa 2314201 ctgataaaac tggcggtaac ggcccgtctg aggacgttca taacggaaca tcggcccgac 2314261 ataataaagc tttgtcggct gtacaggatt tgcgaacagc ttgttttcat taaaagcgcg 2314321 aaccgcagca gctgttccct ccggacgaag cgtcaggctt ctgcctttgc ggtcctcgaa 2314381 ggtatacatt tctttttgta cgatatccgt tgattctccg acgcctctgg caaacagttc 2314441 tgtatgctca aaaatcggtg tgcggatttc tttatattga taagtgcggc aagtgtctct 2314501 cataatttgt tcaacaaact gccagcgatc tgattctcca ggcagaatat cctgtgttcc 2314561 tctcggaatg ttatatccca taggtagacc tccttatgta ttccttataa aatatccaat 2314621 gatcgttaat gatgaaaatg aaaaaaactc ccgcccctac tatacatgat agtagggacg 2314681 agagttatac ccgtggtgcc accctagttg gaatacgttc atattcccgc tcgatccttt 2314741 aacgcaggtt cacgttcact gcctaatggc gttattcacg cgttcagcag gaaacctccg 2314801 gagtgttgtt tcgagaaaga cgcaatggga tccgctttca gcctggggcg ggttcctctc 2314861 taatcatgca atctgaccta ctcttctcca ttattggttc aaatctttca tcatttgcta 2314921 tgtactcaat ttctattata ataatgggat tggggttctc tgtcaagctt tattccggtt 2314981 gtttttcctc agcgctgctt ctttggacat aagaccaaat tcagatgctg tttccgtaag 2315041 ataaccagtc gtatcgggat ctgcgtgatc gctgtaatgc agattcgctt caccgtcgtg 2315101 aaatgcacgt cccatttttg gatgatattt catgatttgc acaccttttt gattgtattt 2315161 acgcttagta taaacaaatc attttatttt tatttaaaaa tcagaaagga ctttacgata 2315221 ttaaacaaga atgctttttt aatgatcatc agaaaggagg acacaatgaa caagaaatac 2315281 tttgtcctta ttgtatgtat tattttcacc tcagcgctat tcccgacctt ttcatccgtt 2315341 acagctgctc aaggagaagc ggtcatcgca acagatgaaa tgaacgtcag aagcggccca 2315401 gggcttagct acggcattac agcggaagta aaaaagggag aacgctatcc aattttaaag 2315461 gaagatggag actgggtgca gatacagctt ggttctggag aaaagggctg ggtagtctcc 2315521 tggcttatta caaaggaaga ccaggccagc acaagctcct caggaagcag tgacactgtg 2315581 acatcaacag accccgatct gcggatgaga agcggcccgg gcacttccta cgaagtcatc 2315641 ggcaaattcc cgcaaggcag ccaagcatct gtcattgata aagattcggg ctggatcaag 2315701 atatcctatc acagtgccac cggatgggta tcatctgaat atgtcacatc aggaggcagc 2315761 agttcagcgt ctgatgagag tgaccaaacc gaggattccg gtgcgtcaac gacgggcaca 2315821 gtcggtgttt cttcgctaaa tgtaagagcc tccgcctcac atgacgcggc aattataaca 2315881 aaacttgatc gcggaacgaa actgacggtt ctcaacgaga aaaatggctg ggctcacatt 2315941 gaggtgaacg ggctaaaagg ctgggttgca agccattacc ttttgactag ttctgttcca 2316001 gctgatgatt cagcaaatgc cggcagttca tcctccgcta aaaaagccta tatcatgtac 2316061 ggaggaacga atctaagaag tgatgcgtca acatcagctt cgatcgttga gcgcgctgcc 2316121 aaaggagatt catacaccat taccggttca aagggaagct ggtatgaaat aaagcttgat 2316181 aacgggcaga ctgcttatgt agccaattgg gtggtccaaa cgtctaaaag cgcagaagaa 2316241 gcaggtgaac cgccagtctc tgattccccg tctggaaacg gctctctaaa caataaaacg 2316301 attattgttg acccgggaca tggaggaaaa gacagcggaa cgatcgggta ttcggggaaa 2316361 ttcgagaaaa acctgacgat caaaacggca aaactgctcg ccagcaaact tagatcggct 2316421 ggagcggatg tatatgtgac acgccaggat gatacctttg tcagcctgca gtcacgggtc 2316481 tctacctctc actaccgtaa cgctgacgcc tttatcagca ttcattatga cagctatgcg 2316541 gatacctcta caagaggcag tacagcatat tactacagtc ctgccaaaga tcaggaactc 2316601 gcatcagatg tccactcaga agtggtgaag cgttcttcca ttccagaccg cggcgtatta 2316661 ttcggagatt attatgtgct ccgggaaaac agacagcccg ctatgctgta cgagctggga 2316721 tatgtaagcc atccgcagga agaagccatt gtacatagca attcatacca agaaaaagta 2316781 acagatggga tcgaaagcgg attagagaaa tacttccaat aaaaaaagct gccttttggc 2316841 agcttttttt attttgaatc cataatgagc gtgaccggtc cggagtttgt aagctgaaca 2316901 tccatcattg ctccaaacgt tccggtctcc actttgattc ctttttcacg aagcaggtca 2316961 ttccattttt cataaagacc taaagcttta tcaggtttgg ccgcgttcat gtagttcggc 2317021 cggcgccctt ttttcgtatc tccataaagc gtaaactgtg agacggataa aatctctcct 2317081 cctatatcta caagagacag attcattttc ccttcactgt catcgaaaat acggagattg 2317141 acaactttat cggctaaata agctgcatca tcttctgtat catcgtgagt gatgccgacc 2317201 agcaccataa ggccttgtcc aatttggccg acgacctctt cgtccactgt aacgcttgct 2317261 tctgttactc gctgaacaac taatctcttt tctaacccct ttagttcatg acgcggcgca 2317321 cagaatagat atctctaatc tgtttaatac gctcgacgac tttatgcaag tgattgatat 2317381 tctggataaa aatcgccata tggatggttg ccactttatt gcgatccgat ttgccagaga 2317441 cagatgaaat attggttttc gtttcattca ctgcctggag tacctcgttc agcaatccgc 2317501 ggcggtcata cccaagaatc tctatctcaa cattgtattc cttgcgcttt tgaacttgtg 2317561 actcatgttc ccactctacc gggatcagcc gctcttgggc ttcattcgtt ttgacattcg 2317621 gacagtcttc gcgatggacc gaaacccctc tgccttttgt gataaagccg acaatatcat 2317681 cacctggcac aggattgcag cattttgata aacggacaag gaggttgtca atgcccttga 2317741 cacgaacgcc agcttcccgt tttcttcctt gcgggtatgg cttaggttcc ccagtgactt 2317801 cctgaacgat cttttcctgt tcttcctggt cgcgctgctt tctctctttt tctgttaggc 2317861 ggttcgccac ctgcagagct gtgatgccgt tgtaaccgac cgccgcgtac atatcctctt 2317921 catttgagaa attaaatttg tcagcaacct tttgaatatt ctccggcgtt aaaacatcct 2317981 tcaattcaaa atccaagttt ttaatttctt tttcgaccag ctcacggcct ttttcgacat 2318041 tttcttcacg ccgctgtttc ttaaagaatt gacggatttt atgcttcgct tgggatgttt 2318101 gggcaagctt cacccaatcc tggctcggac cgtaggaatg cttagaggtg agaatttcaa 2318161 cgatatcacc tgtccgaagc ttatggtcaa gcgtaaccat ttttccgttt actttggcac 2318221 cgattgtttt attgccgatt tcagagtgaa tccggtaaga aaagtcaatc ggaacagaac 2318281 cggacggaag ctcgattaca tctccttttg gcgtaaagac atacaccatg tcagagaaca 2318341 aatcaatttt gagcgattcc ataaattctt ctgcatctgt cgattcattt tgaaattcta 2318401 aaatttcacg gaaccaagaa agctttttct caaaggttgc accttcattg gctgctttcc 2318461 cttctttata agcccagtga gccgcaaccc cgtattccgc tatttcatgc atttcaaagg 2318521 tgcggatctg cacttcaagc ggatcgcctt taggcccaat aaccgttgta tgaagcgatt 2318581 gatacatatt cggcttcggc attgcgatat aatctttgaa tctgcctggc atcggtttcc 2318641 agcatgtgtg aatgatgcca agcaccgcgt agcagtcctt tatgctattc acaagaatac 2318701 ggacagccaa caaatcgtaa atttcattga attgcttatt ttgcagcacc atttttcgat 2318761 aaatgctgta aatatgtttc gggcgtcccg agaagtcagc cttgatattt acttcttcga 2318821 cacgtttctt cacttcattg acaacctcat cgacataaag ctctcgttct gcacgtttct 2318881 tcttcatgag gttgacaatt ctgtaatatt gctgagggtt caaataacgg agcgccgtat 2318941 cttccaattc ccacttaatt tttgaaatcc cgagacgatg cgccaaagga gcaaaaattt 2319001 ccagcgtttc attggagatt ctccgctgtt tttcctgagg cagatgtttc agtgtccgca 2319061 tattgtgaag acgatccgcc agcttgatca atatgaccct gatatcttga gccatagcga 2319121 caaacatttt gcgatgattt tccgcctgct gttcctcttg agatttatat ttaattttgc 2319181 cgagtttcgt tacgccgtct acaagcattg ccacttcttc ggaaaatgct tctttcaggt 2319241 catcgagcgt cacatctgta tcttccacga catcgtgcaa aaatccgccc gcgattgtgg 2319301 aagggtccat ttcaagatca acgagtatcc ccgcaacctg aatcggatga ataatatatg 2319361 gctcgcccga tttgcggtat tgctcgcgat gagcatcttc agcgtacaga tatgcttttt 2319421 cgacaaatgc gatatgctca tcagatagat agctgcgtgc tttatctata acttgctcgg 2319481 cagtcaatac ttgttcgttc gccatggaat cacctttttt aaaatgtaaa ctgtattgta 2319541 gtttattatc aagaaaaaaa cgaaagatgt aaagagcaga agttcaaata gccaaatatt 2319601 atataaaata aatgcaaaac aataggaaaa aagcaccctg acatggagtg ctttttcgtt 2319661 atgcggttat ccttagtatt tcatcaatgt taagatgtcg taatcttcga gcttatttct 2319721 gccgtcaagg taagaaagct cgattaagaa agcgatacca gcaacaacgc cgccaagttc 2319781 ttcaacaagt ttgattgtcg cttcaattgt gccgcctgtc gcaagcaggt catctgtaat 2319841 aagcacacgc tgaccaggct taatcgcatc tttgtggatc gttaatacgt cttttccgta 2319901 ttccaagcca taatccactt tgattacttc acgaggcaac ttgccttctt tgcggaccgg 2319961 cgcaaaacct acgccaagcg cgtaagcaac gggacagccg ataataaagc cgcgcgcttc 2320021 agggccaacg accaaatcaa tttgcttttc tttcgcatat tcaacaattt gatctgtggc 2320081 atagcggtat acatcgcctt tatccatcag tgtcgtaata tctttaaatt gcacgccctc 2320141 tttcgggtaa tccggtacaa ttgttacgta ttgttttaaa tccatctgtt ttatgtcctc 2320201 ctcgtacttt cataagcctc tgaatcttgt ttcatcagct tattcagcca ttccttcagc 2320261 tcttcagcag aagaataatt cagcttttga tccagttcca tcagctgctg tttcgcctga 2320321 tatgtttgtg agtctgttaa gtcgcgtttc tttgctccgc tcacaacaga cagcacacca 2320381 ttctctattt taacaaaacc gagatcaaaa aacacctttg tcatgaaatt gattgtttca 2320441 acggaccagc ctttatgttt tgcaagctct gaaccgtgtt ttttcacgtc aaaagcgcct 2320501 cttttcagca agaacgcata ataccattta aagtggtctc ttgcgggaaa agttgataaa 2320561 aagtggtcct catgattgag aaaaataaaa tatatccgct cgggcgcctt tccttccagc 2320621 aaacgtgcga gcatgtccag cgaaggcggc ggatccagta atacaatata tgcaccatcg 2320681 aggtcaaacg cctttgcttg atctttagaa ctgatgacgt gcacttctcg gcgaaggtct 2320741 tcagtttgaa gtaatgttgt tgagtcttct ttgaaagaga caatggcccg tttagcagat 2320801 ggaagggcgg aaactgtgtc ttcccacgtc cgttttcccc ttaaatcaaa cagctgccat 2320861 tcagaaacag cggcatcctt tatcataagc tgcggctttt ttcgattgtt ccattcgttg 2320921 attgacatct caccgacaat ggaaattctt gaacccggta cgatgccttc ttgaagctcg 2320981 cctttattaa aaccgacgca atcaagctgg gacgactcgt ttctgatcgt cattttgaca 2321041 tgagttttat ttgcccctat cttgcggaca tcttccagta ctgcattttc tacgagaacg 2321101 tgcggtttcg ggttcagcat gccaaaagga gacagcatgt tcatttctgc gatgctttca 2321161 actgtaatgt cttcgacgcc gcagacaagg tcgacttcct gtacgggaat aaaatcctct 2321221 tccgtaagcg tattgtccgc tatttcattc agcctgcttc gcaaatccgg cacatcttcg 2321281 gctttcagcg tcatccccgc agccattgga tggccgccga aatgaggaag aatatctctg 2321341 cattcagaaa ggctctcaaa taaattaaat cctctgatgc ttcgggccga acctttagcg 2321401 attccctttt cttcatcaat accaagaaca atggccggtc ggtagaaacg gtccacaagc 2321461 tttgaagcca caatcccgac gactcccggg ttccatccgg ctttggccac gacaattgca 2321521 gtttgatcga gcccttgctg ttcaaccatt tcaatcgctt catccgtcat tttgctgacc 2321581 attttttggc gctctttgtt cagctggtca atttctgcgg caagctcttc cgcttcaaac 2321641 gaatcctctg acataagcaa atgaacagcg ggatccgcct gttcgattct tccgacggca 2321701 ttcagccttg gtgcgagctg aaatccgact gtttcttcgt tcgcttctcc gatgtctccg 2321761 cctgacagct taatcagctc ttttaagccg agccgatttg tccgtcgaag cctttcaagt 2321821 cctagtgttg ctattaatct gttttcgtca tgcagcggga ctagatcggc aatggtgccg 2321881 atagccgcca ggtcaagcag ttcatcagga agttcaccca ataaagcgtg ggcaagctta 2321941 aacgcgactc caaccccggc aagctcttta aacgggtaag tgcagccagg ctgcttcggg 2322001 tggacgatcg cacggacatc cggaagctcc ggtcccggtt catgatgatc ggtaatgatg 2322061 acatccagtc cgagttcctt tgccaccttc gcttcatgca cagcggcaat tcctgtatca 2322121 accgtaatga tcaaagagaa gccccgttct ttaatcgaac gaaacgcctg ttcattaggt 2322181 ccatatcctt ctttaaaacg gtcaggtata taaaaatcaa cttgagccga cagtttttgc 2322241 agcgtgtgaa gcatcactga cgtacttgta accccatcgg cgtcataatc gccatatatc 2322301 ataatctttt cttgttgtga aatcgcctgt tttattcgat ctgccgcttc tttcatgcct 2322361 ttcatttcaa aaggatcata aaaatcggca tcctttgtat gtaaaaacag cctagcgctt 2322421 tctgccgtat caaagcctct ttttacaagc agggacgcaa caagaggtgt tatatgcaat 2322481 tgttctgtga gtgatttgac cttatcctga tctggtcgct ggatttccca tcgcattttt 2322541 gacgctaaca taaattcacc cctcaaccac cctattatac tagagcaggc tgaggggttt 2322601 caaataatat tcgaaaacta gtcttttttc tcaatcatgg ctgatgcatc ctgtgtgtca 2322661 gtctgatcag caagatgagt atcctcttgt ttatgtattg ctgttctatt ttctttccgc 2322721 aaggttttta tttcccgctt caatttcatt acctgaaaaa tgccgacaga aaatacgatc 2322781 agtgctccca ttaaaactga gcccaaaata acaagaatga gcggccattc tgatcttcca 2322841 aacaggtaat caacttctac ggatcgaaca ttaatgactg cgaaaatagc gacaattaag 2322901 gtgaaaataa gtgcgaaaat aatggtccat tgtttattca ttctcttttc ccccaaactt 2322961 cttattgagg taactttccc aatcaagact ggttttaaac atggcttaac actaggttaa 2323021 gctccctttg ctgttaattt ttcccggatc agcctcttca gtccggttcc ctcaccggaa 2323081 atcacaagtg tatcgccttc gtcaatgact gtttcagagc tcggattcag ttgtttatcc 2323141 tgattctttt taacaattgc aatgaccgtc acatgatatt cctgacccac attcaaatca 2323201 ccaatcgtct gatgaatggc aggcgctccc gcctctgctt tacaccactc tataatcaaa 2323261 tcatcaaggg ctgactcgac ctgttctaat gctttcggtt tatatgccat tccgccaaga 2323321 attgcagaca tttgccttgc ttcagcgtca tcaaactgca cggaggcaac acattcctca 2323381 tggtcgtttt cgtcaaaata gtaaagctct ctccgtccgt catgatgaat gataattgaa 2323441 attttatcac ggtttctagt aatcatttca actttttgtc ctatgcccgg cagctctgat 2323501 tcgcgaaccc tcatatataa accctcctac atatctgaaa accagccata aacactttta 2323561 acaccatata tatgtttaaa tgtaagcgta tgtcattata gcaaatgtct attttaagtt 2323621 caatgaaact tcaaaaaaca ggctgccctg cagaggacag cctgatattt tttattgcgc 2323681 cgaatctttt ttcagttctc ttcctttcca tgcaagccaa atttgtgcgg caatgtatag 2323741 agaagaataa acgcctgtta acagcccgac caataaagca attgagaagt tagtaataga 2323801 agatgctcca aagatcagca atgtcacaac aacaatcaca acggttaata cagtgttaat 2323861 tgaacgtgta aaggtttgct gcaggctcag gtttacaata tggttcagat cggcaaaggt 2323921 tttcggctta cgctttttca tatgctcgcg gaccctgtca aatgtaacga ttgtatcgtt 2323981 aatggaatac ccgattatcg tcaagatggc cgcgatgaat gtaacatcta cctcaagcct 2324041 tgtaatactg aagaacgtga cgataaagaa tgcgtcatat agcaatgagg cgatggcagc 2324101 aatcgccatt ttgtattcga atcggattga aacgtaaata atgatgccaa tagaagctat 2324161 agcaactgcg tacagcgcat ttctcgccag ctccttaccg actgtcggtg aaactgtgct 2324221 gacatttgga tcagatccgt atttgtcttt aaaatacgtt tttacttttg caatggtttc 2324281 tttatctggc accccgacaa aacgggcaac accgatattg ctcttttcgc ctgacagaac 2324341 tacagtatca gggtccatac ccagagattc aaaatccttc tcaacttgct ctgtcgtcag 2324401 cttatggtcg ctttgcactt caatccgtgc accgcttgca aagtcaatgc caagattcag 2324461 cctgaacaca agcaggataa taatcccggc aaccgtgacc gcactggaga aaataaagaa 2324521 gtatttgcgt ttgctcgtga aatcccattt ttggaatggc gtatgcggct ctgtattttc 2324581 atccgtatcc tgaatatcca tgatatgttt cttattgaca ccaaaccagc cttttttccg 2324641 atcaagccat ctgctttcca caaggagagc gaggagaaat ctcgataaga aaacggcagt 2324701 gataaagctt gtcaaaatcg ataggatcag cattgtcgca aaccctttaa cagagcttgt 2324761 cccaaagata aagagcacaa ccgctgcaat aatggttgta atattcgcgt caaaaatcgt 2324821 cgcaaatgac cgtctgtttc ctgaacggaa ggcagagcgg actgactttc ctagcttgag 2324881 ctcttcttta atccgctcat aggtaataat gttggcgtca acagccatcc cgacacctaa 2324941 aatgagagcg gcaattcccg gaagcgtgag tacggcattc atccagtcaa agatctggag 2325001 tgtaatgtag atataaacag acagcgtaat caccgcgatt aatcccggca gacggtaata 2325061 gaaaagcata aataagaaaa taattgcgat accgacaata ccggcaaaca ccgtatcatg 2325121 gagagcctgc tggccgaatt gcgcgcctac tgatgtcgaa tacttttcag tcagtttcac 2325181 aggaagtgcg cctgcgttta aaatgctggc taaatctttc gcttcttgag ctgtgaaatg 2325241 accttcaatt tttacatcag ttgtatttag ttcctgactt acatttggag cggatacaaa 2325301 tttaggatgc tctttttgaa cttctttctt aaaggaatca cctttatcat aatccaacca 2325361 aatgacaagc tggttgtttg gcgccatttt catgaccttc ttggtcactt caccaaattt 2325421 atcagcgtct ttcagcttaa tcgtgacaat tggctcattt gttgtgctat cataagtttg 2325481 tttagcgccg ttttcgacta gatcagcacc gtttaacagt tccttatcat ttgcatctct 2325541 gaaagaaagc tgcgcttcag tcgccaaaat ttcacgcgct ctgttttggt ttgtcacgcc 2325601 agcgagctga acgcgaatcc ggttattccc ttcaatttgg atgttcggtt cgctgacacc 2325661 gagaacattg gcccggcggt tcagtgcctc tactgtgctg accagaacgt cttttgtgat 2325721 tttgtcacct ttttttacag gctgtacatc atacagcacc tcaaatccgc cttgcaaatc 2325781 caatcctaac gtaatattgt tagcggcagg cttcgtaaag tagcccaagc ccgtgccgat 2325841 caatagaacg aaaaggaaaa acgcaatcaa gcgtcctttt ttcattatgt atatcctccc 2325901 ttaaacctgt gcgaatcaac ctgctatctc agcagttctt ccaatgcttc ctggccctct 2325961 tcactgccca gccaattaga cgttttaaat gactcaacgg ttgcatagtt cataaattcg 2326021 ccaattttca ctgataaaat atcactcgcc agttcataaa tgctcagttc cgttttcttt 2326081 ttccacttct tatctgttaa gtatgaccac aaactttcga gttcaacatc atcatacccg 2326141 agaatcttaa actcttccag tttgctgtaa agaaacggcc tgacgtggtc tttatataga 2326201 tcggctggat gcttctccac gaattccacg ctcctttttt attgtttttc aagaagactt 2326261 gtcatgcttg gacgacatat acgcatatct ttattgtata tgattccagg tagtttgaga 2326321 aggcaggggg taaaaatggc gaaacagacg tttttaaagg gcactcttat ccttatcgca 2326381 gcaggaatgg ttacaagaat gctcgggttt gtcaaccggg tggttatcgc ccgttttatc 2326441 ggtgaagaag gagtcgggct ttacatgatg gcagcgccta ctttcttctt ggccactaca 2326501 ttaactcaat tcggtctgcc ggtcgcgatc agcaagctag tcgctgaagc cagtgcgcgc 2326561 ggagatcatc aaaaaacgaa aaatatttta gtcatgtctc tgaccattac gggagtgctc 2326621 agcctcatct ttacaccgct gtttctgttt ttcgcccctg ttatggctga aacgatgctg 2326681 acagataagc gaacactgta tccgctcttg gccattacgc ctgttgtgcc gattattgct 2326741 atatcgagtg tgctgagggg atactttcaa ggaaaacaga atatgaaccc gcttgctatg 2326801 tcacaagtcc ttgaacaggt tgtccgcatt tcactcgtgg ctgtctgcac aacgattttt 2326861 ctcccttacg gaattgaata tgctgcagcg ggggcaatgc tatcctcagt ggcaggggag 2326921 ctggcatcac ttctttattt attcgtttgc tttaagtata aaaagacaat taaaatcaga 2326981 aagcattttt tacagtcaat taaaaacgga aaacaaacct ttacccaatt aatgagcgtg 2327041 tcccttccaa caaccgggag ccgctttatc ggaaacctct cttggttttt cgagccaatc 2327101 gtcgtcgctc aaagccttgc catcgccggt gtggcaacag ttgccgcaac aaagcaatac 2327161 ggggaactaa ccggctttgc catgacgctg ctgactctgc ccagctttat tacatattct 2327221 ttgtcgaccg cgcttgttcc tgcgatcagt gaaggaatgg agcagaaaaa attgcaggtg 2327281 gtggaatacc gcttagaaca ggcgatgcgt ctctgtctgc tcagcggagg catttcagtt 2327341 gttattttat ttgtatttgc ggatgagctg atgagagtga tgtacggttc ctcaggcgca 2327401 gctgtattta taaaagtgat ggccccgttt tttctgcttt attatttcca aggcccgctt 2327461 caagctgtgc tgcaggcgct taatttggca ggagctgcga tgatgaacag cttaatcgga 2327521 gcgcttgtca aaacaggcct tatttttgtc cttgccacaa ggccttctct tggcattatg 2327581 ggcgcggcat tagccattgt gacaggcatg gtgctcgtca cgctattgca cgcagcaacc 2327641 gtaagcaaag tgctgccgat cagcatcaaa atcaaggagt acgcgctcag cttcgctgtt 2327701 attgtaattt gcggattcat cagctccgcc atcaaacaat atataagctt tggagcatct 2327761 gaggctgtca atctagccgg atggattgcg gcgagcgccg ccatttatat gatcctcctg 2327821 ctcgttttcc gtttaattaa aaaagatgag cttcgccgca ttcccattat cggacggttg 2327881 atcatccgat aatggtcacg tgcggtgccc atctttttca tcaatatata tttctccgtc 2327941 tgtaaacgag caaaatgaaa tatctgaagg gtttgtgtat ccgtgttttt gcaaactttc 2328001 aagcagccat tttctatctt tactgattct ggacaggttt tctgtttgaa tgaagccgtc 2328061 tataatgagc ggcatttcga gctgccgatg ctctccgctg ttttctttct taacaatagt 2328121 cagtttgccc gacggctcta aaatagcaaa tgatacgtca gctactctgt cgatgctatt 2328181 ttctctgagc tgaaccatta aatcatcaaa attataacgc tgtgatttca tggcttcttc 2328241 gtcaattttt ccatatttga taattatggt cggcttaccg tcaagaagct ggcggacttt 2328301 tcggtttttt aaagaaaagt atgccaaagt cacttgaatg atcattaata caagcattgg 2328361 caaaatggta tgaaatagat gatcgtctac gttttctatg gctaaaacgg caatttcagc 2328421 catcatgata aagacaacga gatctaaaat actaagctct ccgatctccc gtttgcccat 2328481 gaaacgaaaa atgaccaata tcacaaaata caatacgact gtgcgaaacg caatagtgag 2328541 aagctcttcc attatgcacc tccaactcat tataggttgc aacaaaatga tcaatttatg 2328601 taagaaaaac cgattgcatt tcacaaagct tttacgtcta attcatggga taagggaata 2328661 catttttaca aagacgagcc atcagcatgt ctgacggttt tgaacaaaaa gaacagaagc 2328721 cttttaatac aggcagagag gagacaatca tggaggaaac gaaacaagtt ggaaaaggca 2328781 ttctttacgg cttaatcgcc atattttcag ccatgctcct gacaagttta gcggtttcac 2328841 ttttattgac cgcaacctcg ctggaagaat catcatttaa ctggctgatc accgctatct 2328901 catttctctc tttatttatc ggcgggttca tttcaggcgg gaaaggcaag gaaagaggct 2328961 ggatgattgg cgcattgacc gccttaagtt tttctctgat tatcttattg tttcagtatt 2329021 taggattcgg aaagacattt acagcagaac agctgatctt ccatctggga tttttagggg 2329081 tgtgcatgct gggcgggatt ttcggcgtga acatgagggg aaacaggtct tccacataaa 2329141 aaagagcggg ctcacttgcc cgctcttttt tgtttgctat gtatagctcc tgctgttatt 2329201 cagcagcaga aacttctctg atcgcgcggc ggtcgaacgt aagacgtgtg ttatcaccag 2329261 tcttaattac gactttgctt tcgtcgatag agtcaacagt accgtgcaat cccccgattg 2329321 tcactactga atcgcctttt ttcagttcct cttgcatttg gcgtacagcc ttttgctgct 2329381 tttgctgagg acgaatcagc aagaagtaaa ggaccgcaaa cattaaaata ataggaacca 2329441 atgtacctaa agtgccagtc atcattttca cccctttctg taagcctgtt atgtttattt 2329501 agaagctttt cgcatttggc ttgttatagc cgtaacgctc aaagaactct tctctgaaat 2329561 cacccagacg atcctcgcga atagcctgtc ttacctgctc cattaagtgt aacagaaaat 2329621 gaaggttatg gtaagttgtt aatcgaaggc cgaatgtttc attgcagcga atcaagtgcc 2329681 taatgtacgc gcgagtgtag tttttacatg tatagcaatc acactcttca tcaatcggac 2329741 ggaagtctct ttcaaatttc gcatttttca tattgagtcg tccttcagca gtaaacactg 2329801 tgccgtttct tgcaatccgt gtaggcagca cacagtcaaa catatcgacc ccgcggatcg 2329861 ctccgtcgat cagtgcgtcc ggagaaccta ctcccatcag atatctcggt ttatccttcg 2329921 gcaagagcgg tgttgtgaat tcgagtacac ggttcatgac atccttcggt tcacctacag 2329981 acaatccgcc tatagcatat cccggaaaat caagcgaaat caagtccttc gcactttgtg 2330041 tccgcagatc ttcatattct ccgccttgta caataccaaa cagcccttgt tcatcctgac 2330101 gattgtgggc attcaggcag cgttccgccc agcggcttgt ccgttcaact gacctcttca 2330161 tgtagtcgta ctccgccggg tatggcgggc attcgtcaaa cgccatcata atatcagagc 2330221 cgagtgcgtt ttggatctcc atcgcttttt ccggagataa aaacagcttg tctccattta 2330281 gatgattgcg gaaatggaca ccctcttcct ctatattacg aaacttgctt aaagaaaaga 2330341 cctgaaaacc gcctgaatct gttaaaattg cgcggtccca gttcataaat ttatggagcc 2330401 cgcccgcttc tttgacaatg tcttggcccg gacgaagcca tagatgataa gtgttgctca 2330461 aaatgatgcc tgcatccatt gctttcagct cttcaggcga cattgttttg actgtcgcca 2330521 gtgtgccgac cggcataaaa accggcgttt cgaaggagcc gtgaggcgta tgcactttgc 2330581 ccagccgcgc tcctgtttgt ttgcattctt ttataaattc atagcgtatt ggttgttcag 2330641 ccacttttga tgaggcctcc tgttctcaaa ttatataatc agcatcgcgt ctccgaagct 2330701 gaagaaacgg tattcctctt ccactgcatg gttataggca cgcagaatgt tttctcttcc 2330761 agcaagcgcg ctgaccagca taatcaatga cgatttcggc aaatggaagt ttgtaatcat 2330821 tccgtcaatg gctttaaatt catagcccgg ataaataaaa atagatgtcc agccgcttga 2330881 tgctttaaat tgcccgtcat gttctccggc aatcgtctca agcgtgcgtg tcgaggtcgt 2330941 gccgacagaa atgatccgac cgccattttc tcttactttg tttaaggctg cagccgtttc 2331001 ttctgacatt tgataaaact ctgcatgcat attatgctct tccacttcat cggcactcac 2331061 agggcgaaac gttccaaggc ctacgtgcag tgtgatgaac tcaatttgca cgcctttgtc 2331121 tttcagctgc tgtaagattt cttccgtgaa gtgaaggcca gctgtaggcg cagcagcaga 2331181 gccaatttct tttgaataca ctgtctggta gcgctctttg tcatcaagct gttctttgat 2331241 atatggaggg agcggcatct ctccaaggga ttcaagcacc tcgtagaaaa taccgtcata 2331301 ttgaaattcc atctttctgc cgccgtgctc aagctcttcc gtgcagattg ccttcaatct 2331361 tccgtctcca aatgtgacaa cagttccttt tttcacccgt ttcgccggtt tggcaagtgt 2331421 ttcccattta tcaccggttt cctgtttcaa caaaagaagt tccactttcg cgccggtatc 2331481 ctcttttgtg ccgaataacc gcgcaggcag tacccgggta ttgttcagga ctagacaatc 2331541 gccttcgtta aagaagctga taatgtgttt aaacgagctg tcagtaagct ctcctgtatg 2331601 tttatcgagc accatcagcc ttgaagcatc acgctgctcc aacggtactt gtgcaattaa 2331661 acgttctggt agttcaaaat caaataaatc gactttcatg atgatttcac ctttattcta 2331721 gtcttttgtt atttcattct gccaaaaaga ttaagcaaaa ttgataatac cacacttata 2331781 ataatacaag tgacaaccgg gaagaaaaac gtaacatttc ctttttttac aaaaatatct 2331841 cccggcatct tgccgacaaa atgcaaaact gctccgataa taagcaaaac agcaccaaga 2331901 atcataatga tcttaggaaa ttcagtcata tcggggagcc tccatttgga aatgatgata 2331961 aacggccggt gtcacgatcc ttccacgcgg cgttctttgt ataaatccaa tttgcagcag 2332021 atatggttca tatacgtctt caatcgtatg cgattcctcg ccgatggtag ctgaaatcgt 2332081 atcaaggcct actgggccgc cgttgaattt ttcgatcatg cccatcagca gcttatgatc 2332141 aatatgatcc aaaccgaggc ggtcaacctg aagccgctcc agcgcattct gagaaatgtc 2332201 ttccgtaatc ctgctgtcac ccagcacttg ggcgaaatcg cgcacccttc tcagcaggcg 2332261 gttcgccacg cggggcgtcc ctctcgatct tcttgcaatt tcaagagccg acggtttatc 2332321 aatctcaacc tcgaatacat cagcggttct tgtgacaata tccgccagtt cttcttgtgt 2332381 atagtactca aggcgagaca ttacgccgaa tctgtctctt aaaggagccg tcaaaagccc 2332441 caccctcgtc gtggctccca ccagcgtaaa aggcggaagg tcgaggcgaa ccgagcgggc 2332501 agatgggcct ttgccaatca caatgtccag gcaaaagtct tccattgcag gataaagcac 2332561 ctcttcgatc gatctgtgca gcctatgtat ttcatcaata aataatacat ctcccggttc 2332621 cagcgccgtt aatatagcag ccaaatcacc aggcctttca atcgcaggcc ctgatgtcgt 2332681 ccgcaattcc actcccattt cattagcaac aatcgaagca agcgttgttt ttccgagtcc 2332741 gggcggcccg tacagaagaa catgatccag cgtctcctgt ctcattttcg ccgcatctat 2332801 aaacacgcgc aaattttctt ttaccttatg ctgcccgata tactgtgcca gattttgcgg 2332861 cctcaggctt tgctctatca ctgattcatg gttgtctgct tcacttgaga cgagccgttc 2332921 atccatgaac atcaccttac tttaatagtt tttgtaatgc ttttttcaca tattggtctg 2332981 ttgtcagccc aatttcttct ttaaggtgag gaagcacctt tttgatttct ttttcagcat 2333041 atccgagaac cctgagggct tcaagtgctt cttcaagagc cgtttccgct gtttgctttt 2333101 caagcctttc ttcatgatta aacagatttt caatcatttc aggcacaaca tctgccagct 2333161 ttccttttaa atctagaata atctggcgtg cggttttctt tcctactcca ggaaacttga 2333221 ccaaaaaagc ttcatcttca ttttcaattg cttggatgac cgctccggga tcacccgagc 2333281 ccaagatggc aagtgctcct ttcgggccaa ttccggtcac gtttaacagc tttgtaaaga 2333341 gcgccttctc ctctcttgtt gaaaaaccat aaagcgaaaa agcatcctct ctgatatgat 2333401 ggtatgtaaa aatcgtttct tggcttctct ccttatatat aaacggattc ggcgtgaaaa 2333461 tctgatagcc gatgccgccg ttctctatga caatatattg gggagataca taatcaatcg 2333521 tccctttaac aaattcaatc acgcaaattc acctctttga ctgttcttca ttgtaccata 2333581 aaaacagcca aagtcttata gaaaagttaa catatgttcg cttctctctc attctttcac 2333641 gaaaaaaaag acatgaatac atgtcttcaa tcagcggacg ctacccgctg tatgtcttca 2333701 tatgttcgat gacatcctca aactccgctt ttgtccgaaa tggaatgcct ttcagcagat 2333761 ttttttgcat atggctttcc agcctttcta aatcaatttg aaaaaaagac tgaattggtt 2333821 cggaagctgg ctcaggccgc ccatgaaaag tggaaatcac tccattatcc gatacaccga 2333881 tatacccgtt gaccttgctg agcggagaaa tatcgtccat ttgcttccgg aagagcacat 2333941 atcccttttt ttgttccact agcgtccatc cggcataagc tgcccaaaaa tcatccatag 2334001 aaaacacttt ttcatgctta tgctcaatgc tgacatcgcc gtccaaatac accttttcaa 2334061 gctgcacatg cacctgcagc ggctcatagt gctccacttc cgcgccaagt gcgcgggaag 2334121 gagctcctat taaaaatact gccgctgagc aaagaatgcc cagcaaaaga tacgccgtgc 2334181 tgaatcgttt caccctctac acctctttgc acacgtttat gattagtttg accaaagagg 2334241 ctactgctta accgttttat caaaatttgt ctgcacattt tccctgacaa accgttcctc 2334301 cgtatacaca tctgtgcttt gctcagaaat tgtcaagaat cgcgtcagaa aggcactgaa 2334361 aaaatacaat gccgcaaaga tccaaatcac gccacctgca ccgagcggcc caatgaaaag 2334421 actcacgatg cccggcgcga taaacgcaca taaaccagat cccaaattca acactgacat 2334481 ggcagcacct ttattatcag gtgcaagcgt cggcaaaagc gcgcttaatg ggacgtaccc 2334541 tgctaaagcc gcgccgtagc agcaggcgat aatcatgagc acccaatact gatgcccgat 2334601 cagctgaggc gtgtaataca gcgccagcgt aaaaataccg catccgacac cgccaaacca 2334661 catgaccgta ttgcgccagc ctagtttatc tccgactgca ccgaaaatga tattaaacac 2334721 aatattcaca aaaaacagcg tcccccatat ttgcagccat tccgaaaccg aatacccgta 2334781 tcgtgctaaa taagtaggaa gaaagatggc aaatccaaat tgtcctatcg cattaatcgt 2334841 cttgaccact ccgccgatgc ctaccttagg gttttcaaac ataatcgtaa atgccttcga 2334901 cagttctttc catttcggct gatcttgttt ttgtatcgga gtaaatttat ctttgttaaa 2334961 aaataaggca agaattccgc ctgccgccac aaacagtaaa gcgctccaaa gcgtattgat 2335021 ttctccaaag gccggaactg catagctgga atagaacgga ccgagcacgt taaggccgca 2335081 cgtaaacata aaccaaaacc agccgacggc ttttccaaga atattttgag aggtgctgta 2335141 tgacacccat acgagaaaag agtatgcaaa cagcggatat cccaagcctc taagagcata 2335201 gctgcccaag agagccggat aatacatatg aggaatcgcc cagccgataa aagcggccga 2335261 accgaggata aatgcaagca atccgacagt catcgttttt ctcggccccc aagtttggac 2335321 aaacgttcct gaaagccaag ctgagatggt gacagcaatg ccgtacatgg taaataacga 2335381 tgcggattgc tgcatactga gaccatgatc aacgagaaaa ggagacagcc agccttgttc 2335441 gaggccgtct ccaaccataa agatgacaac gccaatataa ccccaaacca tgtgagaagg 2335501 aattccgatt ttgttcaaaa catttccttt agcatgtact gtattcattt tctccaccgc 2335561 ctacttaaag tatcaatgga gtatataccc aagcttgctg aattgtaatc ctgttagatt 2335621 aaaaagcgat tttttcagtg tgctcaatgc taacaggcat gccaaaagca agcgattgct 2335681 gtgctgctct ggcgatcctc ccggcctgta aaccgtcatt gccggtgcag ggagtctcct 2335741 ggtttgtgcc gatcgcttct gcaaaacgga gaatctcctc ctcatatgaa tccttatagc 2335801 gttcaaggaa aaagaaatgc ggtttatcct tcatcacaaa atcagctgtt gacacctcaa 2335861 ccgttgtcgg cctgctattg tcagccgctg cagagccttt cgtcccgaaa acctcaaccc 2335921 gctggtcata tccgtacaca gcttggcggc tgttatcaat cacagccatg gcaccgtttt 2335981 caaaagtcag tgtaataaca gctgtatcaa tatcacccag ctccgcaaaa gaaggattca 2336041 ccaaagccgc ccctttggca tacacttccg tcacttcgct tcccataata tatctggcca 2336101 tatcaaaatc atggatcgac atatccataa acaatccgcc tgacgtacgg acataatcta 2336161 tattcggggg ttctgggtcc cgggacgtga tttttaataa atgaggtgta ccgatttcac 2336221 cattttcaac aatcgttttg attttcttaa aatgaggatc aaagcggcgg ttaaatccga 2336281 cttgaagtgt taccccgtgt ttccggacag ccgcaagcgc ttcactcgtt tcgtccagag 2336341 agaaactaac gggcttctca caaaatatat gctttttcgc ctcggctgct tctttgatca 2336401 tctgtgcatg tacggctgta ggagagcaaa taaaaatagc atcaatatca ggatcatgta 2336461 ataaatcacg ataatcagag gttatgtatt caatctgatg actgtcggcc cagcttttta 2336521 tacggctcgc ctgaatgtca gagattgctt ttattttcat gtgaggaatc cggcttatat 2336581 tttgaacatg aagtttgccg atgcggcctg caccgataat ccctgtcaca atctgttttg 2336641 tcatggcttc ttcccccttg atcattcacg aaagcgcttt atttaaaatt aatactatcc 2336701 catttgtaag cgcttttcaa gaatggaaat taaacgttct atgtctcttt tatcacaatt 2336761 catgcttata agtagccttc ttcttcaaga ccagatacac tagaattagg ctctttttcc 2336821 tgaacagttt atgattttcc tataaacagc tgcataaaat agagcaaaga aggtgaatga 2336881 aatgctgaca aaagcagagg cactggccca taccgtcata taccgcaaga acagcagatt 2336941 tgataaagtc aaagagaaat ccgaggaatt aacactaatc ggcaagggaa gaagcgccta 2337001 tgtgtttgcc ttaacagaag gcggtcgaaa aatggcgctg aaagtatttt ttccggaata 2337061 tcaagcgaca gcagtcaaag aagcagcgat ctatgaaaaa ttagccgggt ccgcattcta 2337121 tcctgacatt tacgaaactg gcgattcatt tattctcatg gaatatatta aaggtgaaac 2337181 cttttataac tgtctgaaga aaggcattgc aatcagtgat gacatgattc agcaggttga 2337241 agaagcgctt tctgacgccc gggcagccgg actgaacccg tcagatattc atttgcggaa 2337301 tctgatattg acagaaaccg gggcggtgcg ggtgattgat gttgcgagat ttgagcagac 2337361 aaaaacatgc acgcagtggg acgacttaaa atccgcatat catgcactct acaaaaaacc 2337421 gatattcccc aaaaagattc cgggtttttg gctggagatc atcgcatttt tatataagaa 2337481 agattggttt caaaagcatt tcgcacagcg gaaaagaaaa tattcttaaa tcaaaaaggc 2337541 agccgcacaa gcggctgcct ttatcatgta ttttttactt tctgacggca gaaatcagtt 2337601 tcatttgttc aggcgacagc ttaattcgat agcctctcac agttaagtag accgcttctg 2337661 ggtccttctc gccggaatga caatacgttt tttccatttc tgtctcccct caccctttat 2337721 tggctttatt tcatcttatc attgctttat tgaggtaatt ttaaagaaat gtaaagatta 2337781 tatgaatccg atatatagta aaatgagaga aaaaaaggga gagagtcaca ttaagaccga 2337841 aaacaccttg agcttagatg cagccagagg tgaacttgta aatgaaaaaa cacttgtcaa 2337901 gagaacaatc tactggaatt acccggacag ccgcccagca gtgacgtgga tcaatcacaa 2337961 tacagtgaaa atcggcaatc agactttaca tcttgatact gatgaaacgt atgattggcg 2338021 aaaagatgat cattggatcc gtgaagaacc gccgcaggcg tcagtgaggt gatgaaacat 2338081 gaataagatg aacggaacaa atgatgaaaa gcatttcaat cattttgtga ttgctttatc 2338141 ctttatatac ggtttgactg aactaggcta tttgttgctg aaggatttta taacaattgc 2338201 cataagtttg cctctgtaga aaaacgcagc gtagtcgata cgccgcgttt tttctttttc 2338261 ccttcctctt cttattgata attacaggtc atataatgtg acaaatcgat tgtagaaata 2338321 gttcgattag accaaaatcc tttttataca tgtattcgaa tttgaagtga gggggaagct 2338381 tgatggcaga ttttgttgct agtttgaatg cggtcttatg gagtacgccc gtcatttata 2338441 ttttattggg aattggattc gccttttcaa ttatgacccg ttttttacaa gtccgacatt 2338501 taaaagaaat gattgttcag atgttcaaag gcaagagctc tgaagccggc gtttcatctt 2338561 tccaagcgtt atcgattgcg ctgtccggcc gtgtgggcac aggaaacatc gcgggagtgg 2338621 cgacagcaat tgcattcggc ggacccggtg cagtgttctg gatgtgggcg attgccttta 2338681 tcggggcggc gagtgccttt gtagaatcaa cgcttgctca aatttacaaa gtgaaacaag 2338741 acggtcaata tcggggcggc cctgcttatt atatagaaaa aggcttaggc attaagtggt 2338801 ttgccgtctt atttgccgct gctgccctta ttgcaatggc ctttctaatg ccgggcgtac 2338861 agtccaactc cattgcggct gggatccaaa atgcattcgg catctctcct ttcgtcacag 2338921 ggtgcggtct ggttttatta ttagggttca ttatttttgg cggcgtcaaa cgaattgcca 2338981 atgcggcgca aatgattgtt ccatttatgg ccattggata tatcctgctg tctttgatta 2339041 ttattgtcat gaatgtgtct gaattgcctg ctgtgatctc attaatattc aaaagcgcct 2339101 tcgcattgga ttccgctttt ggcggcttga tcggtatggc gatttcctgg ggcgttaaac 2339161 gtggcattta ctcaaacgaa gccggccagg gaacaggccc gcatccggca gctgctgcag 2339221 aggtttctca tccggtcaag cagggactgg ttcaggcatt ttctgtttat attgacacct 2339281 tgtttgtatg ttccgctaca gctttcatga tcttgtttac cggcatgtac aatacccagg 2339341 ctgcagatgg ttcctttatc gttcaccagc ttaaaggcgt agaagcagga cctggtttca 2339401 cacaagcggc aattgacagt gttcttcccg gattcggtgc aggctttgtt gccatcgctt 2339461 tattcttctt cgcttttaca acaattatgg cgtattacta catcgcagaa acaaatatcg 2339521 cctatttagc acgaggcaga gaaagcaaat gggcgatgct tggcttaaaa ctgattattt 2339581 tagccgccac gttctatggt actgtgaaaa cagcttcact tgcttgggca ttaggggatg 2339641 cagggcttgg cattatggta tggctgaacg tcattgccat tgtgctgctt gccaagccgg 2339701 cgctccttgc tttaaaggat tatgagcgcc aaaagaagca gggcttagac ccgatctttg 2339761 atccaaaagc gctgggtatc aaaaacgctg atttctggga gaaagaatac actcatgaaa 2339821 gtgaacgtgt ctcctgaaca tactaaaacc ggcccgatat gacctcgtgc cggtttttta 2339881 tgaacgatag tttgtataca cttcttgaac atcatcgtca tcttcaagga cgtctattaa 2339941 tgtttccagc ttctcaacag cctgatcatc ggcttctgca taggtattgg gaagcatggt 2340001 cacctccgcc gaagaaatta gatatttcga ttcgagggct gttttcacct cttcaaaatg 2340061 ctcaggctct gtgaaaacct catataggtc ttcttcaatt cgcagctctt ctcctcctgc 2340121 ttcaagcaca tcaagcatga gctcatcttc ttctatttgc cgttcagtac ggtctatcgt 2340181 aatgaacccc tttcgttcaa ataaaaaggc tacacatccg ctttctccca gacttccgcc 2340241 atttttatta aaggctgtcc gcacatttga cgccgttcgg tttttattat ctgttacgca 2340301 ttcaaccatg acggcaatcc ctgaagggcc gtagccttca taggtgattt cttcatagct 2340361 gcttccgtct tggcctcccg cagctttttt aatggcccga tctatatttt cattcggcat 2340421 attggcgcct tttgcttttt cgatgacaag acgcaatgct gaatttgctt ctggatccgc 2340481 tccgccttct ttcgctgcca catagatttc ttttgccagc ttcataaata ttttcccgcg 2340541 ctttgcatcc tgtgcatttt ttcttttttg aatgtttttc cacttggaat ggcctgccat 2340601 gttttcacct tcttttacat tttctatgta cactttaatg ggaaatgttc gctgatgcaa 2340661 agaaaaaggc tgccgaatat cacttccggc agcccttcct tcctagcggt tgttcatttt 2340721 atgaagtttt ctgaacagcc ctttatctgt tgatacttgg acgtcacggc catttgcata 2340781 gttgcgcgct gcttttacaa cattatctct gtcagacttt gtgaactctc tgtggctttt 2340841 gactgcgata actactcggt catccgatac cataacttgt gtgtcattga cgtttttcac 2340901 ttgtttcaca cggttggcaa tttttgcagc cagtcttctg ttttcttggt tgtcataccc 2340961 gttgttcgct gcattccgat tcatgtttcg gttattcgtg ttgttatatg ttccgtcagt 2341021 tgccaaagga acacgatcgt cagcagtaac acggtcacgg ttatttacat tcgtggtgtt 2341081 tcggttaccg tcgttctgat cctccattaa ttcagaaaca ggaccatcgt ggtcgattcc 2341141 gtctccctgt ctatcggcgt cattttcatt tgtataatat ccgattggac gggtattgcc 2341201 gttattgcgc gtatcattca tagcattatc gtttgctccg catgctgtta agccggctgt 2341261 cattagaatc aggctagcga tcgtcatttt tttacccaat ggaaaaaccc cccgtggacg 2341321 aattgagcat gtttgctcgc ttttatcatg tgcgtatggg gggcatgtta agcgtgtcag 2341381 ttctctccat ttggcagtga tctgcttgaa aacaaaaaaa ggaacgattt acatcgttcc 2341441 gaacgatcac tcattttctt cttccggacg gccaaacatt tggtttacag aaggctggtt 2341501 cgtcattggc atagaaactc ctgccgaata tgggtttgga tttgggttag ctgtgccata 2341561 tggcatatta gggcttccat aagctcccat tcccgaatgg ccaggtgcag agaaatatgg 2341621 ctgatgatca ccgtcacagc cgcagtcgtc atgatctttg tatggcatgt aaccatgagc 2341681 cgcagcaggc tggtatgctc ccattacttg gggagtgccg taataagggc catacggcat 2341741 atgtccatac ggagatccat aagccggaga tgcgtattgc ggcgcaccgt atgaaccgta 2341801 atgtccgtga tggctgtttt catgatgctg gttttcataa cccgggtcat actgaggcga 2341861 tacaaagcct ggctggtatc catgcatcgg atgcattgga taagcttgtg ccggatagta 2341921 cggatagcat aatcctgatc ctggaagaat tggcgaaaca ggcaccggac acggtacgaa 2341981 atgagccgga taatgataat aaggctgaac agccggcatc ggcatattcg gaactgtgtg 2342041 atgaacgttt tcctcttcta taccgcctac ctctggcgcc tttggcatat taggcatatt 2342101 cggataattt gcattttcca tattactcat agcctcctgt tgtggaaatt ggtcttgcat 2342161 atgatacata tgatccatat ttccgtcatg atgttttttc ggctcctccg gtttaggagg 2342221 cgaccaaggc tggaaaagct gtttcatatc ataataatcg ttcacatcag cttcagggta 2342281 cacattttcc tgcaaattag gcatcggcgg gacatacggc atggacttct tttctttcgg 2342341 ctttgtgtct tctacatcga caacggattt aggcttctct ttcgcatatg gatgttcttg 2342401 cttcacactc ccggccgcag gacttttgcc cgcttttggc tcttttctga ccgggactcc 2342461 ttctgacggc acttttattt tcattccagg catgattaag tctggattgc taagctgtgt 2342521 attgagtttt ttcacttcct caacatcgac tccgtacttt tcagctattt tccagagcga 2342581 atcgcctttt tgaacgatat ggattttcaa cgttttcccc tcctatgcaa aacgtgaaca 2342641 gttcagctgt gattacaata tgtttcttca caacatatgc ctgaacaaaa gaagttatga 2342701 gtaaaggaag ggaaaatatt tctgatctac gtgatcgaaa gcattcgatt cagggcaagg 2342761 agtgcatctt cctgaatggc ttttggcacc ttgatgacgc ctgaaggttc tcctttttca 2342821 atttgttcca gcgaccacaa caaatgcggc aaatcaattc ggttcattgt caggcaaggg 2342881 cacatgtcag ggttgagtga ttcgatttgt ttatctggat gctcgtgaat gatccgctga 2342941 acaagattca tttctgtccc gattgcccac ttgcttcccg ccggagcctg gttgattgtg 2343001 tcgataatat atttcgttga tccgttatca tcgcttagtg tcacgacttc gtgtgaacat 2343061 tccgggtgca caatgatctg aatgtcgggg tctcgctctc tcatatcatg gatattttta 2343121 gtggtgaatt tctcgtgaac agagcaatgc cctttccaca aaatcacttt cacattcgta 2343181 tgcccggatt cagctactaa ttcatctttc atcggatccc acacagccat atcttcaagc 2343241 gcaatgccca gatcataagc cgtatttctc cctaaatgct gatcaggcaa aaataaaatt 2343301 ctttttttct gtgtaaacgc ccattcaagc acttttttcg cattcgaaga agttacagtt 2343361 gctccgccat gctttccgac gaatgccttg atctccgcag tggagttcac ataagttaaa 2343421 ggtatgatcg tatctccaaa tatatgctga agcttcttcc atgccctatt ggtctgctgc 2343481 atgtcagcca tgtcagccat agaacatcca gctctcatat ctggcaggac gaccgtttgc 2343541 tgctcgcttg tcagcatatc ggcggtttct gccataaagt gaacgccgca aaatacgata 2343601 taatccgctt ctttgttttt ttccgctact tgggccaatt gcagggagtc gcctgtttgg 2343661 tcagcaaatt gtatcacttc atccttttga taatgatggc ctggtataaa gagcctgctg 2343721 ccgaactttt tcttaatggc ggcaacgcgc gtttccatat cctttctcga tagttcttta 2343781 taactttcgg gcatcatatc attcgattgt ttgatcacat caagaattga cataacagca 2343841 ttcctccaca gattcatttg ataacgtaac atccatgctg atatctaaac ttttgacgga 2343901 atgagtcaga aatcctaatg aaatataatt cacacccgtc cctttaaaag caggcaaaga 2343961 ttctaacgta atcccgccag aggcttcagt ttttatatta gccggtgtga gctttgcaaa 2344021 atgacggacc gtatcaggcg gacagttgtc aaacataata acatccgctc cagctgcaat 2344081 tgcttcccgc agctgttcct ccgtttcaat ttccacctcg atatttacca tgtgccctgc 2344141 ggcctgacgg gcttttttgc acgcctctaa aatagagccg catgctgcga tatgattatc 2344201 tttaatcatg atgccgtcat acaaaccgaa tcgatgatta tacccgccgc cggctctgac 2344261 agcatatttc tccagcattc tgagccccgg tgttgttttt ctcgtgtcac aaattttaat 2344321 ctgttcatca tccagacacc gaacagcctc tcttgtcatt gtcgcaattc ctgacagcct 2344381 ctgaataaga tttaatacga cccgctctcc tgaaaggagc gcagctgcgg gaccgtgtaa 2344441 ctcggcaatc acttcacctt tatgcaacat gtccccatct tttttgtgta aaatgctttg 2344501 aacattttcg tccaataacg aaaagccttc ttttatgatc gctgctcctg caaaaatacc 2344561 ctctgacttt gcaacaatct ccgcttcaca gctctgttct ccaaaaatag actgcgatgt 2344621 aagatcccct gtcccaatat cctcaagaaa aaagtgattc agtaattttt tcagctgtaa 2344681 atgattcatt gttccaaatc ccctcgtttt ttctgatctt cgttcctttt tttgtatgga 2344741 caatttgtct tccttgccag ctcacctcag catgaggaaa atcggtgcgg aagtgagccc 2344801 ctctgctttc ctcccgcaaa agcgcagaaa acgtcatcag ctttgcagtt tgccatagat 2344861 gagaaagttc catctgccga attgtgatat ccttcacatt tacttcctga aaaggcagcg 2344921 tatgaagcca gatgctaagc tcaatcaaac tgctttgttc ccgcagaata gacatgtggc 2344981 ttgtcatttt gctttgcagt tcatgcccct ctatatccgg cacctcgtag aagacactgg 2345041 tttctagccc tgattgatat tgcctgttat aaaccggttt ttggataata tgctctgctg 2345101 ccctttttcc aaataccagc gcttccaata aagaattgct tgcaagccgg tttgctccat 2345161 gtaaaccgga gcatgctgtc tcgccaatcg cataaagccc cggcactgtc gtttctcccc 2345221 agcgattaac tgaaacacct cccattaaga aatgcattcc cggagcaaca ggaatttttc 2345281 cgctgtggat atcaatccct gctttttcac aaatagcggt gatggtaggg aaacgcgttt 2345341 caaaatcaga aatcgcactg aagtctatat aaacgcgatt tccttttgcc atttcttcgt 2345401 gaataacccg tgagacaata tctcttggag ccaggtcacc taaaggatgc cgttcagcca 2345461 taatcctgcg gccgttttcg tctactaaac atccgccttc ccctctgaca gcttctgaaa 2345521 caagcccgta ggaaacacca tttttcacaa gcagtgtcgg gtgaaactga gtaaactcca 2345581 aatccgttaa ttccgccccg gcccggtaag ccagagaaag accgtcacct gtgacagtga 2345641 gatcattcgt atggtgaaga aacaggtttc cacagccgcc ggcagccagc acaacttcgt 2345701 ctgcgtgcct taccttgagc cgccctttgc tgtcttttgt catgacgccg atacatcgtc 2345761 cgtcctctat aagcaaatct gctgccgttt cattctcgat taacttgatt ttgctgttga 2345821 tccgtttgag caaataatcg ataagcagcc tgcctgttgc gtctccgcct gcatgaaata 2345881 tgcggttgta tgagtgggcc ccttctcttc caagacaaac accgcctcgt tcattgcggt 2345941 cgaatggaaa tccacgctcc aataggcttt gaaccatcat ttttccatca tgtaatacgt 2346001 ctgctacaat agctagatta ttatggccgc accctgcgta taacgtatcc tccagatggg 2346061 cttcaatcga gtcatctttt gcataggccg cagcaatccc gccttgtgca tagacagaat 2346121 tgctgttttt gacgcttttt tttgtgataa cagtcacttc gtatgagggc gggaaagctg 2346181 cagctaagga aagtgccgcc gcccctgaac cgatgactgc aatcgtcttt ttagacatat 2346241 gccatcctcc tgttgtttac acctgtcttg acacctatat ttacacaagg ataaaataaa 2346301 ctcaagagtt ttttatggag aacggatgga ggaagaccgg atgatttatt tagattatgc 2346361 agcgacaacg cctatttgtg aggaagccct tactgtatat cagaagctta gtatggatat 2346421 gtacggaaat gccagcagcc tgcatgatgc aggaggaaaa gcaaagcaca tactggagta 2346481 ctgccgtgaa aaaatcgcca acatcattgg cggagaagca agcggcatct attttacaag 2346541 cggcggcact gaatccaatt ttctggccat tcaatcattg ttaaacggcc tgccaaaaac 2346601 gaaaagacat tttattacga ctgccatgga gcatcagtcc attcataatt gcgctgcttt 2346661 tttggaacag cagggatatg atgtaacagt cattgaaccg aatgaatacg ggcttattac 2346721 cgaggaaata ttactaaccc atatccggcc ggaaacaggc cttgtatcta ttcagcatgc 2346781 aaattctgaa accgggatca ttcagcccat tcaacacctg tcttcatacc tgcacaataa 2346841 ggggattctt cttcattgcg acgctgttca aacgtttgga aagatcccga tcaatacaaa 2346901 aaatctggga gtagatgcac tctcaatgtc cagccataaa atccacggtc ctaaaggagt 2346961 aggggcggtc tatatccggc cggatgtccc ttggaaaccc gtttatcctc tgactactca 2347021 cgaatacgga ttcagagccg gcaccgtaaa tgttcccggg atcggtgcct tcactgccgc 2347081 tgcagaattg atcgtaagcg aaatggaaaa acagatatcc cgcaatgagg cattaagaac 2347141 atactttcta gaccaaatcc gtattcggtc tctccctgta acccttgcag cagacacttc 2347201 gaaagcagaa tgtcttccgc atattatagg gtgttttttt cactcatttg aaggacaata 2347261 tgttatgtta gaatgtaatc ggagtaatat ttgcatttca accggcagcg cttgttctgc 2347321 aggttaccac ggtccgtctg aaacaatgaa agcattaaga aaaaccgaac aagaagctct 2347381 gcaatttatc cgcatctctt ttggcaggca tacaacagct gaacagctgg aacagttatt 2347441 acatacgttt acagtgcttt gggaacaaaa gaaaggagaa tttgatattg accgaagaat 2347501 taaagctaat gggcgccaac aggcgtgacc agcttcttct gtggctgaag gaatctaaat 2347561 caccgctgac aggaggagaa ctcgcaaaaa aagcgaacgt ctcaagacag gttattgtac 2347621 aggatatatc gctcttgaaa gcgaaaaatg taccgattat cgccacaagc caaggatatg 2347681 tatacatgga tgcagccgct cagcagcacc agcaggcaga aagaatcata gcatgtctgc 2347741 acggtcctga acggacagaa gaggaactgc agctcatcgt cgacgaaggc gttacagtaa 2347801 aagacgtaaa aatcgagcat cccgtatacg gagatttaac tgcagccatc caagtaggca 2347861 cccggaaaga agttagccat ttcatcaaaa aaatcaattc tacgaatgct gcctacttat 2347921 cacagctgac cgacggcgtg cacctgcata cactgacagc acctgatgaa catcgcatcg 2347981 atcaagcctg ccaagccctc gaagaagccg gcattttaat taaagactaa aaaaagccct 2348041 ctagtgggct ttttttataa ttggtaagac tggtatgcac ccagaagcct cactttgcag 2348101 ccgagtgctt caagctcctg catggcccct ggaatcaata catcatcaaa cgctttctca 2348161 atatcaataa taaagaaata atggcctaat ccggttttag tcggacgtga ctcaattttt 2348221 gacaggttta aatttctcca agaaaatgca gacagcactc tatgcagcgc cccggactga 2348281 tcatcctgcg gcagcatgac cattaaggtc gttttgggcc tagagctcaa ttttgaattc 2348341 acttcaaaag atatgttttc atcgggagac aggataacaa atcttgtatg attgtcccta 2348401 taatcctgta tatcccgttt cacgattttt aattcgtatg tagaagctgc catatcattg 2348461 gcaatgaccc cgatattcag ctcgggatgg tcactgacaa actttgctgc cgccccggta 2348521 gaattggcgt attcatatgg aacggaagga aaatgtcgat gaagaaattt atggcattgc 2348581 gcaatcgcgt gtgaatgtga gtaaattttg tcgagctctt tccatgcatt ctctcttgag 2348641 ggatggacga gcaagtgctg gtgaatcggc aacgtcattt cacccacgat tggcaaaggc 2348701 tgttcatgta ttaaatagtc tattgttaga ttaacagatc cttctaaagc attttccaaa 2348761 ggaacaaaag caaaatcaac ttcgcctgca acggctgcat ctatacactc cggaatggtg 2348821 cggtaagcaa catgttcggc gccgttttga aaacaagaac tgactgctag atgtgtaaat 2348881 gtagctgctg gacctaaata accgactttc atgacgattt tctctccctt atgcacctga 2348941 acctaatatt tcaacctttt ctacaaaatc aaacttcctg agcttattca ttaatgtatg 2349001 aatgtcttct tccattgccg acgtactgat agacagtgtc acatttgctc tgccttgaag 2349061 cggaatggtc tggtgaatgg aaagaacgtt gcttccagaa tcagctaccg cctgaagaag 2349121 ctgagataac gcacctgacc tatcctccaa atgaaagaaa agtgtgataa tttgttcttt 2349181 taccatggtg tagaatggaa aaacagcatc cctgtattta taaaacgcac ttctacttaa 2349241 atcgaccttt tgaacggcat ctgctactga atctgctttt tttcgatcaa gcagcttttt 2349301 gacttctaat gtttttctca ttgcatcggg caatacatct tcacggacaa gataaaatgt 2349361 ctcctctttc atttgcatcc cccctttaaa atagagagcc tggcaccagg ctctcttttc 2349421 agccaacatt gattaatcaa taaattcaaa ttcaaattcc agaagcctga ttatatctcc 2349481 atccttggct ccgcgttctc tgagtgcttc atcaacaccc attccgcgca tctgtcttgc 2349541 aaaccgttta accgattcat cacgtgagaa atcagtcatc ttgaataacc gctcaaggct 2349601 gtctcctgaa agcacaaata caccgtctgg atcgcgtgta atgttaaatg gcacttcttc 2349661 attttccatc gtgtacatga cacggttttg tgtaagctct tcctcgtcat acagcgggaa 2349721 ttccggtgtg ttctcaagct gattggcaac ctcaaacaga agctcacgca gaccttctct 2349781 tgtcaccgca ctgatcggga ataccggata atcatccgtc agcttttctt taaaggcttc 2349841 gagattttcc gcagcctccg gcatgtccat tttatttgca acgataattt gcggacgctc 2349901 agtgagacgc agattgtact cgctcagctc ctggttaatc gtaagataat catcatatgg 2349961 atcacggcct tctaagcctg acatgtcaat gacatgaaca ataaccctcg tccgttcaat 2350021 atggcgcaaa aactggtggc ccagtccgac gccttggtgt gcgccttcaa tcagccctgg 2350081 caaatcagcc atgacaaagc tgcgtccgtc atccgtttca accatgccga gattcgggac 2350141 aagcgttgta aagtgatagt ccgcaatttt cggttttgca gatgagacaa cagacagcaa 2350201 agtagatttt cccacactcg ggaacccgac aagtccgaca tctgcaagca cttttaattc 2350261 aagaacaatg tagcgttctt ttcccggctc gccgttttct gaaagctgag gcgcgggatt 2350321 agccggtgta gcaaagcggc tatttcctct tccgcctctt ccgcctcttg caatgacagc 2350381 ccgctgtccg tgctctgtta aatcagcgat gacctgtttt gtatcatcgt ctgtcacaac 2350441 ggtgcccggc ggaactttaa tgaccatatc atcagcattt cgcccgtgct ggtttttgga 2350501 catgccatgc tcgccgcgaa tcgctttaaa gtgttttttg tatctaaaat ccatcagggt 2350561 gcggagacct tcatctactt caaaaacgac gtctcctccc tttcctccgt caccgccggc 2350621 agggccgcct ttcggcacat atttttcacg gcgaaacgca accataccgt tgccgccgtc 2350681 gccgcctttt acatatactt tgacctgatc tacaaacata atgtcctccg ttctaaaccg 2350741 ttaaaaactc cgctagtcca acccaatttc aatcagacat tcgtgactcg tgatttcaaa 2350801 acgcatgata tcaacgtcct catatccatt ctgccgaata tcatcaaaag cagatggatc 2350861 ggcaaaggcg ccgtgaaaat caaggtacag aatcagctgt ctgtcaggat gatccgtttg 2350921 aagcgaaacc gttaaatgat tttcactctc tctgctgact gcttgatcaa acagatgaaa 2350981 cagctttctc atcagtttcg ccagcttttg atcataagcc gacaaatcct taatttctcc 2351041 gagaacttca tattcaagcg tcatataatg ggttttccaa ttaaacgtaa gaaaatcaaa 2351101 cgccaaatgc ggtgttttca ggtttgagag ctttgattcg tgctttgcgt ctataaccat 2351161 ttcttcaatc atttcaaaga cacggtcata cttctgtaag cttaagtttc ctttaatcag 2351221 ctgcagctta ttcatccaat catgccggga atggccaagc agatgaatca gttcgtttgt 2351281 taatgccgtg tcgcttatat tttcttcttg attttttgaa acatccttca ttttcgcact 2351341 cccaatcatt taatttctta tttaggagtc tgtataagtg tgtattatga attataacag 2351401 agaaggcttt gttagaaaaa caattgtttt tcccagaaat atcatgttcc ttttttctgg 2351461 ctttggttga tttgcagcca ggcagaacat tttatgtatt actgcttggg gaacatatcc 2351521 agtgggtttg agatgtttat tctcattctt ggcggggtct gctcgcacat actctgcatt 2351581 tcattctagg tgtttactcc gcatattgca aaaaaaactc cagtcatcat cgaccggagt 2351641 tttttgaatc attattgagc tacaggatat acgctcactt ttttgcggtc acggccgaaa 2351701 cgttcgaatt taacagttcc gtcgattttc gcaaatagag tgtcatctcc gccgcggccc 2351761 acgttttcac ctgggtaaat ttttgttccg cgttgacggt aaaggataga accgcctgtt 2351821 acgaattgac cgtcagcacg tttagcacct aaacgtttag cctcagagtc acgtccgttc 2351881 tttgtagaac ctactccttt tttagaagcg aaaaactgaa gatctaatct aagcatgtag 2351941 ctcacctcct atattatgtt tgtggtcaca cgcaagttgt ctttgtaatc ccgttcgatt 2352001 gtctccagcg aaacaatcat gccttcaatc agcagctgag ctttttggcg tgcctctgga 2352061 tcaagagatt cagggaattc aaaataaaaa taacccccgt cctctcctat atcaagaagc 2352121 ggctcgaagc ccgcgagcac aatgaccgcg ttaacggccc caaacacaac ggctgtcact 2352181 ccggcacaaa caagatcttg tccatgttca gcaaaattcg catggcccgt catttcaaaa 2352241 gacaatatgc ctttatcatg agaccttctg attgttgcct gaatcatgct tacgcgttga 2352301 ttttttcgat cgtcacttta gtgtaaggct gacgatgacc ttgtttttta tgaacgtttt 2352361 tctttggttt gtatctgaaa acagtgattt ttttcgcgcg gccttgtttt tcaactttag 2352421 ccgttactgt tgcgccttca actgtagggt tgccgacttt cacgttgtct ccgccaacaa 2352481 acaaaacgtc ttcaaaagta actgtttcac ctgcttcagc agcaagtttt tcgatgtaaa 2352541 cagtttggcc ttcttcaact ttgatttgtt taccgcctgt tttaatgatt gcgtacattc 2352601 tctgcacctc ctattagact aagactcgcc agataccagg gggctgtaaa agctcttaac 2352661 acctgtactg agcggttgta gcaatggtgc tacatccata acattaaaaa atataccaaa 2352721 atacaaggcg tttgtcaatc agttttagta gggcagaagc agttcctcca tggaagaatt 2352781 cgtccgctta tcggcaaagt aagcgtgcag cacttcattc tcgtcaagct ggctgagctt 2352841 ttggcctgat ttttctataa taatcggatg cttacagcca cgtttgaact cggccatcac 2352901 atgatagact ttatcctccg cctttactgt cagcggcaga agtttctcaa gctccctgtt 2352961 ttttccgtaa tacctttcga ggagaaatct cacatggata tagtgccttt gccgatattc 2353021 ctcaaacaag gaaacagcca gaaagacaaa caaaacccat gcgctgattt gcagaggaat 2353081 cacgaataaa acccagcacc cgagcagcag gcagaagcag agcgacgttt ttagattaag 2353141 ccggtgagcc ttttgaaaag gcagctgttt ggaaaacaac aaaaataaca gttttcctcc 2353201 atccagcggc cagatcggca gtaaattgac aaataagata gaaagattat aaaaggtgaa 2353261 gagttcaaag gtatgctgat gaatcactga gacttctgca agcatccagg cggcaaactg 2353321 aagccagatg tgctgaagag gtccggcaat aatgaccgca aactcttcct ttaacggccg 2353381 attcccgtgc tcttccactt cgaccgttcc gccaaacggc agcaaaaaaa cacgcttgat 2353441 tctccaagaa aaaaacacag ccagagcagc atgccccagc tcatgaatca atacaatcag 2353501 gagcagacat aataatgctt tcatatggcc tgtgagcaag cccagcgccg caataatcca 2353561 aagaaaagga tgcacatgga tctttaagat aaggtcgagc catttattca aatgaaatca 2353621 cctgaatcgg atcaataaat ttatcgccgt ctttcatggc aaaataatag acccctttat 2353681 tatgatcatc aagcttaatc gaaccgagct ttttgccttt atccacaaaa tcatataaag 2353741 caacatccac atctttgagc tcgccataga tactataggt gttgtcagca tgctgcacct 2353801 taaccgtcag tcccgtttgg ctgtctttgc tgacttcaac cacatagcct tcttttacgc 2353861 tatcaatctt atcactgctt gtttcgactt taattccttc cccattgtcc tgaaaatcct 2353921 gctgtacttt cccggatgca ggcgcgatca gatctttgcc tacttcaatc tgctgttcct 2353981 tatttttgtg ttcaggagcc aggaaagcaa gcggatttcc gaatttggtt tcgaaccaat 2354041 ggcttgctga agcaaattga aattcagttt caaaggtttt ggctacggcg ggtttaatct 2354101 gactgacggg tccaatgttt gttttatagg ctatagctga aacgagaaca aggcaggccg 2354161 acagaagaca tttcaggata attgaatctg ttttcaccaa tgggtgtttt ccgttgaatg 2354221 ttggcatgtt atcttcgtag accggaagtg ttccatgctt ttcctgatcc gttaccatca 2354281 cccaggacgg gggtttctgc ttttcagaaa ctgtctgagt agagaaacgt tttgagccgg 2354341 aaagctgctt tcttcttttc tctaatcgtt ttctgatttc atctgctctg tgactcattg 2354401 ccatcatcct ttgcattcgt tgggtttgta catcatatgt cttgtccatg gcaaatattc 2354461 ggtttagtca agaacaaagc aggcaaaaac aaaaaaaacc tgacacagca tatgctttgt 2354521 cagattcttc tctttgattc tatcacatta agatcttact ccgaaaaatg acttaatctt 2354581 agccatcatt cctttgtttt gctcttcaag cacctgtaaa ggaacagatt cacctaagat 2354641 gcggcgggca atattgcgat atgcaatgga agcgcggttt ttagggtcca tcgcaatcgg 2354701 ttcgccatga ttggaagctt taatgacttc atcatcatca gccacgattc cgagcaaatc 2354761 gatcgacaga tgctgtacga tttcgtcgat atccatcgtg tcaccgtttt tcatcaggtg 2354821 atttctgatt ctgttaacaa cgagccgcgg cggttcaata ttttcctctt gctccagcag 2354881 tcctataata cggtcagcat cacgaacagc tgagatttca ggcgtagtga ccacaatcgc 2354941 tttatcagct ccggaaacgg catttttgta cccttgctcg attccggcag gacagtctat 2355001 gatgacatag tcaaattcct gtttgagctc ttggaccatg tttttaattt gttcaggagc 2355061 aacagctgtc ttatcgctcg tttgagcagc gggcattaaa tagagcagat catcgaaacg 2355121 tttgtctttt acgagcgcct gatgcatttt gcatctgccc tctacaacgt ctaccagatc 2355181 gtaaataatt ctattttcaa gacccattac aacatcaagg ttgcgcagtc ctatatcagt 2355241 atctactaag catacgcgct tccctaaaat ggctaaggcg gtaccgaggt tcgcagatgt 2355301 tgttgtctta cctactccgc cttttcccga agttattacg atagcctcac ccaattcaca 2355361 ttcctccctc aagccttgtt agatcaggtc ttaaatgagc caaatgttga aggcgttcaa 2355421 tgaccatatt tccgtctgta tctaaataag cacattccat ttcgttccct ttttgaatgt 2355481 ggtctgggga gcgatttaac acatgattga ttcttaattg tgtcggaagc atttcagagg 2355541 cggcgatgac cgcttgatta tttccattga atccagcatg cgcaattcct ttcagtgagc 2355601 ccagaacaaa aatgttccct ccggccctga ctgttccgcc gggattcacg tcaccgatca 2355661 ggagcaagtc gccttttacc tgcagcactt ggcctgaacg gacaattttt gaaacagaaa 2355721 taatttcggc ttcctctctt atctgctgtg cttctttttt agtaatgact tcactgtcaa 2355781 tagaatgaac aaacaaatct ttctttgacg caatcaattc ggttagctgt tcctcttgct 2355841 ccttatataa aaagcgattt cccagcttaa catgaacgct gattttctgg ccttttccat 2355901 cggtatattg ttcaattgac agcatattct gaagaccatc gagaagctca tcaaaagaac 2355961 acgcatcatc cagatgcaat gttagtccat tctttgttcc ttttattgtt acatattgct 2356021 gctttttggt cttcacaata ttcacctcaa caacatactc atttcgtcaa aaaaagataa 2356081 aatccttttt actcatctct caattctttc tttagactca taaaaaacaa tctaaatggc 2356141 agaacaagaa taagagctgc tgcaatattt aataaaattg tcggtataaa ccggtcaagc 2356201 acaaatccgt taaacgtcat aatgtcttta tgaatcaaag actgaatgcc gaatacgtaa 2356261 aattcgagca gacagacagc cagaactgct atcaatatca ctacaaatgc gtttgtatgc 2356321 aacactttaa acgcttttga agccaaatag catagccctg caaaaccaaa catgtaaacg 2356381 cctaatagac ttgtatagtt catgtcatat agaaagccaa aaataaatcc gtaaatcatc 2356441 gcgtgttttt ggttgataaa agccgacatg aatatcaata caagcatcaa aaaacgcggg 2356501 gcgagcactt ggtcatctgt aacgaaagga aaatgcacca aatctgtaaa aatgctttcc 2356561 gcagaaaaaa caagcatcat aacgaaaggg agaaggaaac gtttcacgat ccttcctcct 2356621 ctgtatcgac agtcggcacg tcacggttaa caacgatcac attatttaaa tctgtaaggt 2356681 cagccgcagg ttttacataa gcaaccttcg ttaatccata ggaatctgac tcgatatcag 2356741 tcacttcacc gattgtcagc ccttctggga aaacaccgcc tgtccctgat gtttcaataa 2356801 gatcgccttt tttcacgtct tgtttatcct tacgctcaat aattgtcatc ttaagacgtt 2356861 ttttctcttt gtcatatcct tcgatcaagc cgtagccttt gctgcctttt tttccggaaa 2356921 tttttgtcgc gactctgtta ttgcggtcag tatcgcttaa aagctgaaca gcagacgtaa 2356981 aattgttaag tccggagctt ttgatcttgc cgattaatgc gcctttttcg tttgtaacgg 2357041 ccatatcttt cgctacgttt tgctgagtcc ccttgttaat ggtgacctgt ttcgcccaat 2357101 tatcagggct tctggcgatg accgttgcta aaatcggctt gtaatcttta atcgatttga 2357161 catggccaag ctcgtcacgc aaggatttgt tttcttcttc aagctcttga agcttggctt 2357221 catattgtgt ctgtccgtca agtttttctc ttagacgctc gttttctttg tatgtgtttt 2357281 ttaaatcatt gatgttctca aatattcctg caaaaaattc ggcaggcgta tgaaaaatat 2357341 tttgaaatac tcccgtcgta tcgccgatca ctttctcagg ccaggtggta ttgcggccgc 2357401 ccttcagcga aaatccaatc atagccacca atatgataat acacagaagt aatagcatta 2357461 accgcttatt cggcatcgtg ttacacctct tctattgaac tcccgattat ctagttttcc 2357521 ctttgaaaag atggatgtgc tccagtgctt tccctgttcc gatcgctaca caatcaagcg 2357581 gatcttcggc gataaggacc ggcatttttg tttcttcgct gatgactttg tccaaattgc 2357641 gcaaaagcgc tccgccgccg gttaacacta tacctctgtc catgatatct gctgcaagct 2357701 caggcggtgt tttttcgagt gtgctcttca ctgcttcgac aattgtagat acagtgtcgc 2357761 gtagagcgtt agaaatctct tttcctgtaa tttcaattgt tttcggcaaa cctgtgagca 2357821 aatcgcggcc gcggatttcc atgttgtcgg attcttcagg agcttctgca gatccgattt 2357881 ccattttaat cgcttcagcc gtacggtcac cgatcatcag attgtacgtt tttctgatgt 2357941 agttgataat cgcgtcatcc atctcatcac cggctacacg gattgactga gacgttacga 2358001 tgcctccgag ggaaataatc gcaacttctg tcgtaccgcc cccgatatca acaaccatgc 2358061 ttccagtcgg ttcccaaact ggcagattgg ctccgattgc tgcggcaaaa ggctcttcaa 2358121 tcggatacgc gtcacgcgct cccgcctgtc ttgtcgcatc gataacagcg cgttcttcaa 2358181 cagctgtaat gcctgatggg acacatacca ttacatatgg ttttctggca aacatgcctt 2358241 tattttttat ggcctgattg atgtaatatt tcatcatcgt cgccgttgtt tcataatcag 2358301 cgataacgcc gtctttcatc gggcgaagag ccaccacgtt gcccggtgtc cgtccaatca 2358361 tatttttcgc atcatttccg acagcgacaa tcgatttcgt atccgtctgc aaagcgacaa 2358421 ctgacggctc tctcacaaca attccttttc cttttacaaa aacaagcgta ttcgcagttc 2358481 caagatctat accaaggtct ctagcaccaa ttccaaacat atgtatgtat cttcctttct 2358541 taaagcaaaa ataccctaaa gggaaaaact cataaactct attatagctt aattcgacga 2358601 aaaaaaaagt gttacaaata tcctttttcc tttaaactca caaatttttt atccccgatc 2358661 accaaatggt caagcagctc gatgccaatc aggtttccgc attcaaacag ccgtcttgtc 2358721 acttcaatat cttccctgct cggcgtcgga tctccagaag gatgattatg aacacagata 2358781 aaggaagcgg cagatcgttt aaacgcttct ttaaacacct ctcgcgggtg gacaatagat 2358841 gaattcaggc ttccgataaa tacggtgcgt ttatggatga cttgattttt tgtatttaag 2358901 tataaacaga caaaatgctc ctgggttaaa aagcgcatat cctccatgac aagattagcg 2358961 ccgtcttccg gggagcgaat aacgaaatgt tcttcgttgg ctaatttatg aatccggctt 2359021 ccaagctcaa ctgctgccag tatttgaatc gcttttacca taccgattcc cgggatgctt 2359081 gacagctctt caaccgatgc ttccttgagc aggcgcagcc cgtcaaatga gcgcagcagc 2359141 cggtttgaca ggtccaaaac agattcgtgt ttagtccctg tccgcaataa tatagccaaa 2359201 agttcatgat tcgctaagtt ctcggctccg actttcagga gccgttccct tggcttttct 2359261 ttcattggga aatctttgag ttttaatggc agatcgtgta tgaccaagca ctccttttct 2359321 ttcccttccc gtttatagaa ccgtcatgcc cttatatcaa aatggcgaag agctctcatt 2359381 gtttttgata taggaaggcc catgactgaa taataatctc cgtctatttt ctttacaaaa 2359441 agcgcgcctc ttccttggat gccgtatgca cctgctttat ccatcggctc ttttgtttca 2359501 atatatgtcc aaatctcttc ttcactgagg gaccaaaacg caacttctgt cttatcataa 2359561 aaagtctcgc tgtgattttc agcttgaatg ctgaccgcgg ttattactga gtgacttcgg 2359621 cctgaaagcc tccgcagcat agaagcagct tcttcttgat cctgcggttt gccaagacat 2359681 tcgccgtcaa ggcataccat tgtatcagca ccgataacga ttgcatgcgg gtggagatca 2359741 gctacagcct tagctttttg ttttgccaac cattggacgt tttcttctgg tgaaaagttt 2359801 cgatttaatt tttcttctac ttcactgaca ataatggagt agggcagctg gagaagatcg 2359861 aggagttctt tcctgcgcgg agattgtgat gcaagtatta gcggttttgt catgttcgtc 2359921 atcctttcag ggtttgctta agaaaaaaag atactcgttt atcctaccaa atcacgaggc 2359981 ttgtcacaat ttcagaaaaa taactttttc atgacaaaat aaaaaaagcc tgtcactaaa 2360041 ggacgaaggc tcagggcact atctcttatt ttacgacggc taacagctcc tgctgagcct 2360101 tccacccggc ttcagcactt ggatcctcta attcctttaa agcctgcaaa atcgcttttt 2360161 tctctcctgt ttctgacgct tttgtttcac caagcgactt ttctattttc tctacactcg 2360221 cttttgtaat gtcttcgtcg agaatcgcct ttgctgcaag ctccgctgtt tccttaaaag 2360281 aatctgtcat atctgactct attgataagg aaagctcctt gcctccccag gcttcaaaat 2360341 cactgtcgat taaaacctgt cctaactgct gtgagacctc cttttcactt gctaagcctg 2360401 caataacata cgtatacccg tcatcctttg acagtgacac ggcggaatat cctttttcgg 2360461 tcaattgttc tgttaacgtt tcggcgccct tttcatttga aaattttccg gcttgcacag 2360521 cgtatgtttt gtatgtacct tcagtttgtg ccgcttgttt ttctgcgcct gaggtttgtt 2360581 tatcagcaga agtatcccct gcttttgccg tttggctgcc taaagaatcc tctaaagagg 2360641 ccggtgctga cgcttcttta ttccccgata tgtttaacgc gaataaccct aatccagtgc 2360701 caatgacagc cgcgaaggca atcgtcgcgg ccactctttt taccggtttg gcagccccgg 2360761 tctttccttt tgcgtaaagc tttgtttttt tcttttgaaa aggaggaaca actttagggt 2360821 cctctttaaa caccttgtcc tcctcggaat cccaattgaa ttcatcttca tcagggtgtt 2360881 cctgggatgc cgcaacctct tgttctgcct gtcttttttc ctcccaattt gaaaatgtca 2360941 tgcttttatt cgcctctgtc tcaggcgtct cttgttcgta aaccgtctct tcttttccat 2361001 taatcgtcac cttgagggct ttttctgcgg ctttactgtt ttttttattc tttctttttt 2361061 tcaattccgc ttcctccctt catttgcttg accgttcttg tcggcttttc atgctacaca 2361121 ctttagcaca ggcaaagaaa aaaagaacaa gacttttgtc gccttgtcca aaaaacgttc 2361181 gtcaaatttt tcagcagtca gcccaatgcc attttgatat aaaaagaaat gatagagtca 2361241 ccgtataaat aggctaaaat gctccctgcg gctatagcgg gggcgaaggg aagcggctgc 2361301 cttttagcga gtctaccagt cagaacagct gccgctccat ataatgcacc tatcaaaact 2361361 gaaaagaaaa aggcagctgc cagcattttc acaccaagca caaagccaat caccgcaaat 2361421 aatttaatat ctcctccccc tactccccca tgggtgattg cggcaattac agccagaaac 2361481 aaaaatccgg ctgccgcacc taacaggcct gcataccagg aatcaagcgg agaaatcaat 2361541 ctcgcggccg ccaaaaaggg aagaaagaaa atcaatattc gatttggaat cagcataaaa 2361601 tgaatatctg tcactgcaac aataatgaga agagagataa acaccacagc gggaaacagt 2361661 tccagcgata tgccaaagcg tattcctgcg gcggcaaata aacacgctgt cacaagctct 2361721 gctgcgggat acataaaaga aatcctatgc ccgcagcttt tacatttacc tttttgaaat 2361781 aggaatgaca ggatgggaat taattctgca ggagttaatg ttcgccggca aaacgggcat 2361841 gatgaacggg gcgcaataat agatagatgt aaggggatac ggcacccggc cgtatagtaa 2361901 aaagaaccaa ggataagccc gaagataaaa agaatggata gcatagacaa cacaccttta 2361961 ctcattgagt tctggtatgg attgtagcaa aatggacatc ctgagctcca attgggaata 2362021 ttcaatttta cacatgaaaa aaacggcaga atcttttttt gattctgccg gagccggatg 2362081 cttttatttc aacctttttc gaatgtcaga aataaagtaa agagatccgg taatcagcac 2362141 aatttcattt gagccctttt tactttctat gaatttgatt acatcgtctg gatcttcact 2362201 ccagctttta ttgctgattt cacttgcatc atagagatct tttgcaaggg aagcacgcgg 2362261 gaaatcaaaa gaagcaaaat gaatcgcatg agcaatggtt tccagtcttt taatcatgtt 2362321 ctgatacggt ttgtccttta acgcgctaaa caccacagaa atgcgtgaat tggcgaaacg 2362381 ctgcttcatc gtttccgcca gcttttcaac accttcttcg ttatgcgcac cgtctaaata 2362441 taccggagga tgttcctgaa caagctctaa ccgtcccggc caagcagcct tcacaagccc 2362501 gctccttaac gcttcgtcac tgatatgggc gatattctcc ttattgagcc actccgcagc 2362561 caaaatggac aaagcagcat tttgtctttg atgggtgcca atcagagatg tccgaatatc 2362621 ttcatagcat ttctcttccg ttttgaatga aaactgttct cctgcaggca gagcctcttc 2362681 attgaaaata acacatgcat catgcaatga ctggaacggc gcagcatgcc gttcggcttc 2362741 atggcggatg acctgtaaag cttccggctg ggtaactgct gtaacgattg gaataccttc 2362801 tttaataatg ccggcctttt ctcctgcaat ttcttcaatg gtgtttccca aaatgttcat 2362861 atgatcgtgt ccgatgcttg taatcacagt taagagcggt tcaaccacat tagtagaatc 2362921 gaatctaccg cccagacctg tttcaaaaat aacaaaatcg accttatgaa actctgcaaa 2362981 atataaaaat gcacaagctg tcataatttc aaattctgtc ggctgtccgt attccgtttg 2363041 atcaagggct tcaacgtgcg gtttcatttg attgacgagt gctgtccatt cctcatctga 2363101 aatcggtatc ccgtttacgc tgatccgttc attaaacgta ataatataag gcgatgtaaa 2363161 tgttccaacc gtatatccgg cttcctgcag catagaacgg ataaaagcga cagttgatcc 2363221 tttaccgttt gttcctgcga cgtggaacgc tcggattttt ttttcaggat gtcctaaccg 2363281 cgccatcagc tgtttcattc gaccaagtcc gggcttcacc ccgaatttca gcctcccgtg 2363341 aatccagctg cgcgcatctt gatatgcagt aaacaatgat aatcccctct tttataagac 2363401 aaggcggttt ctctagaaac cgccccggct tttcattaac ccttcagctc agccattcgt 2363461 ttttgaacag cgtcacgctt cgccacataa tctttttctt tttcacgttc ttcatcaatt 2363521 acgtgtgcag gcgctttttt cataaatcct tcatttccaa gtttcttttg gacacgctca 2363581 acttcttttg tcagtttatc aaattctttt tgcagacggg caatttcttc atcaatattg 2363641 attaagcctt caagcggaag aataacctct gctcctgaga caacggccgt catcgcctta 2363701 tcaacagcct caatatcggt gccgatttta agcacgctcg gattcgtaaa gcgttcaaca 2363761 tatgaacggt tcgcttcgag gcgggacgct atttcgtctg tgcttgtttt aatgtacagt 2363821 tcaacctgct tgctcattgg cgtattgact tcactgcgga tattgcgcac agaacggatc 2363881 agctcaacaa gaagcttcat gtcagctgcc gcttcagtat cggtatgctc cggcactact 2363941 gcaggccatt gacttactgt aatcgattcc ccttggtgag gaaggtgctg ccaaatttcc 2364001 tccgttaaga atggcataaa cggatggagc agacgcatcg tttgatcaag tacgtaagca 2364061 aggatggaac gggtagtttt cttagccgct tcgtcttctc cataaagcgg aagcttcgcc 2364121 atttcaatat accaatcaca gaaatcatcc caaataaagt tatataaatg gcgtcctact 2364181 tcaccaaatt catatcggtc agcaagctgg gtcacgtgct cgatcgtttc atttaatcgc 2364241 gttaaaatcc acttgtcagc gactgacttt tcacctgaca gatcaagctc atcgtacgtc 2364301 atgccatcca tattcattaa tgcaaaacgg gaggcgttcc aaattttatt ggcaaaattc 2364361 caggtcgatt ccactttttc atagctgaag cgcagatcct ggccaggaga gcttccagtc 2364421 gcaaggaaat aacgcagaga atcggctccg tacttgtcaa tcacatccat cgggtcgaca 2364481 ccgttgccaa gagatttact cattttccgg ccttgctcgt cacggattaa gccgtggatt 2364541 aaaacatctt tgaacgggcg ctcgcctgta aattcaatgc cttggaaaat catgcgtgat 2364601 acccagaaga aaatgatatc gtaccctgtc acgagaacat ctgtcggata gtagcgttta 2364661 aagtcttcag ccgttacatc aggccagccc attgtggaga aaggccatag cgcagaactg 2364721 aaccatgtat ccagtacgtc tgtatcctgt tcccaatttt cgctgtcttc cggcgcttca 2364781 agtccgacat atagctcgcc tgtttcttta tgataccagg caggaatacg atggccccac 2364841 cacaattgac gggagataca ccagtcgcgg atattttcca tccagtgtaa atacgttttt 2364901 tcgaaacggt caggcacaaa gttgaccttt tcttcttttt tttgcagctc aatcgctgca 2364961 tcagcaagcg gctgcatgcg cacaaaccat tgtgtagaaa gataaggctc cacaacagcc 2365021 ccgcttcgtt cactatggcc gacagagtgc atatgatcct cgatcttgaa gagaactccc 2365081 gcctcctgta aatctttcac gagctttttg cggcattcaa aacgatccat accttgatat 2365141 tggagcgcat tttcattcat cgtgccatct tcattcatga caaggatgcg ttctaaattg 2365201 tggcggttgc caagctcgaa gtcgttcgga tcatgagcag gcgtaatttt cacggcacct 2365261 gaaccaaatt ccatatcaac atagtcatca ccgacaatcg gaatttcacg atttacaatc 2365321 ggcaggatca ccgtttttcc gataaggtgt ttatagcgct cgtcttcagg gtgaacggca 2365381 acagctgtat caccgagcat tgtttcagga cgtgtcgtcg caatttcaat tgagcctgaa 2365441 ccgtcagcaa gcggatagct catatgatag aatgcgcctt gaacatcctt gtaaatcacc 2365501 tcaatgtcgg atagggctgt ttttgtcgct gggtcccagt taataatata ttcgcctctg 2365561 tagatcaggc ctttttcata aagcttaacg aatacttccc ttaccgcttt gctcaagcct 2365621 tcatccagcg taaaacgttc acgggaataa tctaggccaa gacctaattt cgcccactgg 2365681 ctgcgaataa agtcagcata ttcttccttc cacttccacg tttcttcgag gaatttttca 2365741 cggcctaaat cgtagcggga tttgccttct tcacgaagtt tcgcctccac tttagcctgt 2365801 gtcgcgatgc cggcgtggtc catgccagga agccacagca catcatagcc ctgcatgcgt 2365861 ttcattcttg ttacaatgtc ttgcagcgtt gtgtcccatg cgtggccaag gtgaagtctc 2365921 cctgttacgt ttggcggcgg gatgacaaca gagtatggct cttttgtctg gtcactgccc 2365981 gcttcaaaaa atttgccttt tagccaaaaa tcatatcggt ctttttcaac cgctgccgga 2366041 tcatatttcg tcggcattgt ttgttcattc gtttccatca taaccctcca gcatgtttaa 2366101 aaatggctga gaacgaaaaa agagctcttc atccctgtaa aaggacgaaa agctctttcg 2366161 cggtaccacc ttttttcatg aactcaatca gttcatgcac ttataacgga taacgggtgt 2366221 ttcccgaatt tctctactct tctttcaaga aattatgctc ccgggcgacc ttccaatcag 2366281 acaacataag aagcctttca gcaaacggct tctctctctg catgcgcctt ttttgtactc 2366341 ttcccgttct aagcaggtgt atttatcagc tcattgtata cattatttat gttctttatt 2366401 atagtaaaag tgtttttgat tcgtcaatca tcttttccaa aaacaccgct ttctatacag 2366461 atgggcaggc acctattgcc caagtttaca tatgatgctt gtaaatgcgt agaggaggat 2366521 gcaccgtgaa gaaacgtttc agctcttatt cgctgccgcc atgggtaagg caaattcggc 2366581 ttgtatccgc acaagtgatt attcccatta cgatttttca aggaatcaga accattttct 2366641 ttccgacaac ctttgatgtt ttgctgctcg caatcctaat ctttttagct tgcgcccttc 2366701 atttagaatg gatataaaca aacaagtccg cgccattaag acgtggactc gttttcagcc 2366761 tgaaattttt tctcttgttc aatctgatga attttcatca caaacggctc tatgtttttc 2366821 atttgccaat aagcctttaa taattgtgta cattcctctt tttcatgctg tcttttccca 2366881 gtttgataac cgttcagcac cttgtacatg gctgccggat atgccatata gctgagaaaa 2366941 aggctgactt ccgcttcacg caaagggaat gatttcgtat atccataaaa ccattcgacg 2367001 cattccggac aagctttcgg aaagcctctg aacatttttg tataaaagcc gagcaggtcg 2367061 ttttgcggcg gaccgacaga tgctctttcg aagtttgtaa aatatccggt cccggcatca 2367121 ttatacagaa aatggtgtat agacaggctg ccgtggttca ttacaaccct tgaaacgtcc 2367181 ttttcctttg cggactcata ccagtcctcc agccgttcca gcgcaaagtt caccgcggaa 2367241 atggtttcag aaaaataggt tatggcctgg agttcaaagg gagaaaggta ccattccttc 2367301 tccgctctat ccacaaactg ctcatagaaa attttatctt gttcccactt ttttttcgtt 2367361 tgcccgtaat aacgttcaat ctcatcacgt ctaaccttta gttcctgcgc ggttctctcg 2367421 tgaagacggg ctgtttctct aaataaataa gcatgttttt gatcccgttc ttcctcttgg 2367481 tcaaattgga gccaaggcat taaatagtag atatctccgt attgtatgcc tgctgagaaa 2367541 aactcaccgc tatttgttct gtaaacggga acgaatgaac gaaagccttt ttcctcaatc 2367601 gccaccatat gatctgtaaa atgcttgccg cgaccttctt tcaatttttt cagggcaaat 2367661 atgccgtagt ctgtatacac tttccaaaca agaggactga caggctcaat aaattgagca 2367721 gtcagtccgt attcctgaag aaccgattgg gtatcttcca tttcattcac cacattttcc 2367781 gatcacttac ggtttacgca tggctatttt tatattgagg aatatagaga atctgtcctg 2367841 cttttaattc atcatccaag gctaaagaat tcatcctgat cagctgctgg gatgtaattt 2367901 cataccgttc gcataaacgc tcgatcgtat cttcctgctg cacaatacaa attttcattc 2367961 tcgaaaactc atccgcttct tttgtaaaga gttttgttaa ataaagagaa ttatcacttt 2368021 cctttgtttg aggttccttc gtttcagcag caggagcaac cctaggaaca gcatccgttt 2368081 ccttcctttc agtctcagaa gattcaggca gctggaagga ttgaaaaggt gtttcttcct 2368141 taggctcttc agctgatggt gtttttctca cttcaatttc gaagctctct tcctcttgtt 2368201 cttcctcctc cagcagctta ggcgctgaat aaaaagaatc ctcctcttct tgttcaggca 2368261 ggaaggtacg gtatgccggt tcaggcaatt cttcttgaga tgcctcctcc gagcttgttt 2368321 tttgattgaa atggaaatgt aaatcggcat tgtcattctc catatataca gctgaagctg 2368381 tttctctgct atcttctatg gagagagcgg cctctgatac actctccaaa gcttcatccg 2368441 gttccgcctc ttcttggcaa agcgcaggat cagcctgatc cgattgagct gcttcttcat 2368501 tttgagcctc ttggcgcagc gcatattcat gattaggaga cactgttgtt tcctcttttt 2368561 cctttgcaat cacagtctct gaatgaagct cagcttccaa agcaggcgat tcttctgctc 2368621 caacgtgttc acgaagctca gtctccgctg gagagtctgc ttcttcacga acatccgcta 2368681 ttgcagctgc cggctctgcc gtttcttttt ttgctttaac gatctcttga atctctattt 2368741 ctgaaggatc aggttctggc tcagattctt ctgtttccga ttcagcacga acctccgttt 2368801 ccggcacagc aagctcttct gactcttctt cctctttcac atcttctctg gcctctggtt 2368861 ctgaagcaac cgattcaggc ggctcagatt ctgctttttc tgtctccagt tcttcacgga 2368921 gccccgcttt cgagataaaa agttctggcg gttcggctgg cggttcatgc tgaagaactg 2368981 cttcctctgc cgatgatgca cccggttctt ctactacact atgtgccggc ggctctgaaa 2369041 gctcttcctc cctgaatgcc gcaggagctt catataaagg tatctccggc tctttgtctt 2369101 gcgtatcgtc caaaagccct tcgatcgcta aatcagcttg aattgttaaa atgcgcgaat 2369161 ccgtcaattg atagtcaaat gcgtcaataa agacgaagac atcctgtaaa tggctcactt 2369221 tatttttcgg aatggtaata tccacaggaa aacagtgagt cagttccgca cttccatcct 2369281 ctctctttct gacttgttca acaaaccgct tatctgtata aatctcttcg gtatgtttgt 2369341 tttgatctat gttgtactca cctgtaagtt caagcgatcc tatgattgat acataatcat 2369401 ttacttcctg aaccctaata tcaggatcta atgaaataga aagcagttca gaaacttcct 2369461 gtcctttttg gaaacagatc gattcttcta cagaaaattg caatcgatga ttttgcggca 2369521 agttcatatc ctcctttcat ctaatcctta aaattagatg tcactaaagg tgtatgtatg 2369581 aactggagaa aatatgagtg ggagagcacg aaaaaaccgg cacaaggagt ccttgatacc 2369641 ggttttcact cttatctgcg gctgatctca gcaaatactt tctcagctgc ctggattgtg 2369701 ttttcaatat cttcatcagt atgggccgtt gagaggaaaa gaccttcgaa ttgtgatggc 2369761 ggaaggaata ccccttcatt tgccatccct ttataatagc ttgcgaacag cttcaaatca 2369821 gatgatttcg ctgtttcata attgatgact ggttcgtttg taaagaagaa accgatcatc 2369881 gaacctgcac ggttaaaggt atgcggaatg ccatgagccc cggcggtttt tgaaattcct 2369941 tcttccagtc tgtcgccttt tttgatgaaa ttcttgtagg attcaggtgt cagctgtttc 2370001 aatgtctcta agccagccgt catcgcaagc gggttgcctg acaatgtacc agcttgatag 2370061 atcggaccgc ttggagcgat ctgctccatg atttctgcct ttccgccata agcgccgaca 2370121 ggaagtccgc ccccgattac ttttcctaaa caagtcagat caggcgttac gccgaagtag 2370181 ccttgagcgc agttataatc gacccggaag ccagtcatca cttcatcaaa aatcagcagg 2370241 gagccgtact gctcagtgat atcacgcaga ccctgaagga aaccttcttg cggcggaaca 2370301 acacccatat ttccggcaac tggctctaca atgactcccg caatgtcttc accgaattgc 2370361 tggaaagcaa gctttacact ttctaaatca ttgtacggaa cggtgatggt gtttttcgca 2370421 atgccttcag gcacccccgg gctgtcaggc agaccgagag tggcaacacc tgaaccagct 2370481 ttaatcaaga gagaatcgcc gtgtccgtgg tagcagccct caaattttaa aatcttgttg 2370541 cggcccgtat agccccttgc caaacggagg gcactcattg tagcctctgt tccggagctt 2370601 accattcgta caatttctac agatggcaca cgatcaatga cgagcttagc cagttcattt 2370661 tctacttcag tcggagcacc aaagcttgtc ccgtattcag ccactttttt gaggctttct 2370721 acgacgcggt catttgtatg ccctaaaatt aaaggccccc atgacaagac gtagtcaata 2370781 tattcattcc cgtcaatatc aaagattttc gagccttttc cgcgctccat aaaaatcggg 2370841 tccatgtcta ccgatttaaa tgcgcgaacg ggactgttca caccgcccgg catgagtttt 2370901 tgcgcttctt taaaagccgt ttttgatttt tcatagcttc tcatctgcct caactcctgt 2370961 caactgaata aaattactcc gcaagccatt tcgctgcgtc tttcgcatga tacgtaataa 2371021 tcaggtcggc acccgcgcgc ttcatgcttg tcaaaatttc caacacaatt tctttttctt 2371081 tgatccagcc gttctgcgct gcagccttca ccattgaata ctctccgctt acattataag 2371141 cgacgagcgg caaagtaaac tcatttttta cgtcacgcat gatatccata taagaaagcg 2371201 aaggtttgac aatcaaaaag tccgcgcctt cctcaacatc tgattgtgct tcgcggagtg 2371261 cctccatacg gttggcaggg tccatctgat atgttttgcg gtctccgaat tgcggtgtgc 2371321 tgtttgctgc atcacggaac ggaccgtaaa actcacttga atatttaaca gcgtaagaca 2371381 tgatgggaat attgacgaat ccttctttat caagtgcttc tctgatcact gtaacaaatc 2371441 cgtccatcat gtttgatggc gcaatgatat ccgcacctgc tttcgcttgg ctgacagctg 2371501 tctgcgccaa aagctccagc gattcatcat tgagaatgac tccgtctttg acaagtccgc 2371561 aatggccgtg gtctgtatat tcgcacaggc acgtgtcagc gacaacaacc atttcaggga 2371621 agtgttcttt aatttctgtg atggcttttt ggacaattcc gtgatcatgg tacgcttgtg 2371681 ttccgcaatc atctttttct tccgggatgc cgaacacgat aacagattga atgcccagtt 2371741 tgaccagctc cgctacttca tccttcaata aatctaatga tacatggtga acatcaggca 2371801 ttgacggaac agcttttttg ccttccagcc cttcaacgac aaaaatcgga tatataaaat 2371861 ctgatggatg caaacgtgtt tcctttacca tttctctcat tgcttttgat gtccgcaggc 2371921 ggcggtgtct attaaatgat tgactcatat tctctcttcc tctcttgaca tgctgcacat 2371981 taactcaagc atgccatcta ttgtaaatgt atcaggcgta tgcgatgtga tgccgtacgt 2372041 cagaagggca tcatttgtta aaggcccaat gctgatacag gccgtcccat tcgccttcca 2372101 cttttttaat tcttctccca agacatgcat aaacgtatgt acggttgatg aactcgtaaa 2372161 tgttacatag tcaaaggaat attgacccgc agcgtctttc aatgcctcaa tgccttcttc 2372221 atccggaatc gtttcgtaga gaacccattc ctttacttca aaaccgagcg ggacaagctc 2372281 ttgttttatc acatcacgtg acaaattccc tttcatcacg gtaatggtct cccccggttc 2372341 agcatgctgc ttaagagcgt cagccaattg ttcagcaata tactcctgtg gcatcacatc 2372401 aaccgatacg ttatgcattt ttaaacggcg cgcggttttt tcaccgacgg ctgcaatttt 2372461 tttatgcgca gggagaataa gctgattttc cttcagataa gaaaaaaaga agtctgcccc 2372521 gttcacactt gtaaaaacaa gccagcctgg cgcggcaaga tcctctctta cctgttccgc 2372581 aacatcattc ggcaaagcgc ggcgaaacgt aatcaaagag gttaaaaccg ctttaccgcc 2372641 aagcgcctcc actttttgct gaaatgatgc tgcctgtgcc ttattccggg tgacaagcac 2372701 tgtttttcct ttcaacggaa aatcattttc catcctcgtc aagctcccgt tttacacgat 2372761 caattaaatc ttttgctcct ttgtcagcca taagagcggc acagcgcttt cctacttcct 2372821 ccggatcgtt tccggtgacg gtttctttaa aaatgatttt gccgtcaggt gaagcgacaa 2372881 gacctgtcat ttcaatttca tcctgtccat ttaacacgga gtagcccgcg atcggaacct 2372941 ggcagccgcc ctccatcgcg tttaaaaaag cacgttccgc taagacagtc cgttttgtat 2373001 attcatctgt aaactgagaa aacaacgcca acagctcttc atccgattct cggcactcaa 2373061 tcgccagggc tccctgcccc acagcaggca aacagcgctc aggctcaagg aattcggtta 2373121 cgacatcttg cttccaaccc attctggaaa ggccggcagc cgctaaaata attgcgtcat 2373181 aatcctctgt ttccagcttt tgaagtcttg tatctatatt acctctaatc catttaattg 2373241 taaggtcagg gcgctcaatc aaaagctgcg cgcttcttct taaactgctt gtgccaatga 2373301 cagcaccttt cttcatttct gaaagcttta cgcgattctt tgaaataagg gcatcacgcg 2373361 ggtcctcccg ttcaggaata cagccgatca caaggccttc aggcaaaaca gcaggcatgt 2373421 ccttcatgct gtgcactgcc atatcaatct cttcgtttaa aagcgcctgt tcaatttctt 2373481 tgacaaaaag cccttttcca cccacttttg agagtgtaac atcgacaatc cggtcgccct 2373541 ttgtcacgat ctctttaatt tcaaaagcaa acgaaggatt gatttccttc agtttttgaa 2373601 taacccattt tgtttgagtc atagcgagtt tgctccgtct ggaacctact ttaatcgttc 2373661 tcatcatttc tttcctcccg aatctgcttg ggacatcgtt taactgaacc aatggaattg 2373721 cgacaggctt ccaagcagga aataattgat catcagcacc agaaaacaag ccgtattcca 2373781 cagtgcagcg acctttcctt gcagctcctt aatcagcctg atataaagat aatagctgta 2373841 cagcagcagg acgacaaacg aaccaagcac tttggcgtca aaccaataca gcgtttctag 2373901 tgagacatac gcccaaatga cgccgagaat caaactcagc agcagcatcg gaaccccaat 2373961 gacatttaaa acatacgcca tataatcaag cttagataaa tcttctattc tcaacagcca 2374021 ttttccccac tttttctttt tcagcagatg atattgaaac atatatagca cagaaaaaac 2374081 gaaagaaagg gaaaaagcgc cgtatgaaag aatcgccatt gtaatatgaa tcaccaaaag 2374141 ctcggataca agctgcccgg aaaaagcagc tgactgctgc tctgtcggtg aaaatgtgtg 2374201 aatggcgatc atagaaaatc ctataacatt tgtaaaaaac acgataaagt caacacgtaa 2374261 aagctttgtc agtacaagtg acagcgtgac aagcacccag gcataaaaat aaagtgcctc 2374321 tgtcacattt aataccggaa accgccccgt cacccacata aaataggcca aatacacggt 2374381 ttgcagagtc cagacaatag aaagcaacca gaaggccatt tttccagcct tccggttgtg 2374441 ttgaagaaaa tctataaaat aaaagagtac acttaacgcg taaatgacga ttgtcccctc 2374501 attaagtctt gccattgcag tatcaatcat tcagctttca ctcacttaca agtgggctaa 2374561 agcccgcttt tgattcagcc ttcttaaaag agtggacctt ctggctgctt tcaacggttt 2374621 tcatcatttg acggcccgca gcttcttcaa tatcaaaaat ctgcataaac aacgcgagct 2374681 tttcttcaga atcagcatct gccgcaagct ctttcacctt taaaatcgga tcacgaagca 2374741 tttggttaat aatacttttg gtgtgtttgt tcaacagttt tttctctctt gtgcttaagt 2374801 gaggcagctt acgctcaatg ctgtccatcg tttctgactg gatggcaagc gccttttcgc 2374861 gcaatgcaga aataacaggc acaacaccaa gtgtattcat ccattgttta aattccacaa 2374921 tggtttcttc aattaacagt tcaacttttt cagctgtttc tctccgctct ttcatgttcg 2374981 cttctacaat gccttccaga tcgtcgatat cataaagaaa aacaccttca agatcattca 2375041 gcgccggatc aagatctcta ggcacggcaa tgtcgaccat aaacagcgga cgtcccttgc 2375101 gaagcttatt cgcgttttcc atcatctctt tggacacgac aaattcactt gcaccggttg 2375161 aactgattaa aatatcagcc tccgcaagcg cgctttcaag ctgattcaag cttctcgctt 2375221 cacctgaaaa acggtctgca agctccttcg ctttcaagta tgttcggtta atgacagtga 2375281 ccttgccgat tccctgtccg tgcaggtttt ccgcagcaag ctcgcccatt tttcccgcac 2375341 cgagaatcaa tatgtgcttg cttgaaagat ttccgaagat ttttttggca agttcaactg 2375401 cagcatagct tactgacacc gcatttgagc caatgtctgt ttcggcgtga gtccgtttgc 2375461 ccactgtaac tgcctgctta aacagctcat taaaaatagt cccgatcgtt ttttcttgct 2375521 gagctgtttt aaagctgtcg cgtacctgtc cgagaatctg cgtttcgcca atcaccatag 2375581 aatcaagtcc gcaggctaca cggaataaat gctcaacagc ggcatcgctc tcataaaacg 2375641 ttaagaacgg tgacagctct tctttgctta attgaaacca atcagctaaa aactttttta 2375701 tataataacg gccggtatga agctggtcga ctaccgcata aatttcagtg cggttgcagg 2375761 ttgagacaat gatgttttca agaatgcttt tctcttcttt cagctgcacc attgcttctg 2375821 ccagctcatt cggctgaaaa cttacttttt cacgtatctc aataggggcg gatttataat 2375881 ctactcccac aacaagtata tgcatcgctc taattacacc cccaacaccc aatcttaatt 2375941 tataatcatt ctaacataga actcattatt tataataatt ataacatagt ttctttcaca 2376001 aaatgtgaac agattttaaa attcttatgc tatattagaa aaagcttcag ggaaaagaag 2376061 cattcctatt gacaatacca aaaacagcag aaatttacta cacatcagct ctaaaaaaca 2376121 agaaggtgat atgcatgaaa caaaaatcaa ttttattccc ttgtctgctg cttgccgctt 2376181 ctgtatatgc atggctagaa agcggccaag ccgaactgtt ttcagggcag gatcaatggc 2376241 ctgttctcct catgctgtta ggcgcagcct ttgtatatca aggaaaaaaa gaagccgtca 2376301 caccccattt ttttatcggt ttgcttctct tcgggatcgg tttacacttt tttgccaagc 2376361 cgaaatgggt atggtggccg gatgattttg aaatgctcct ctttatgatc ggcttctcac 2376421 ttctcgtttc aaccgttcaa aaaaaagaat atgtatatga agctgtgtcg atgatttgtt 2376481 tttccctgtt tttgtacttt ttcaaacaaa ttatggcatg gcttgagtct gcgcatattc 2376541 caacagcgct tctgaaggag tattggccgt ttgtctttat tggaatcagt ttattgttat 2376601 tattgataaa acgaaaaaaa tctatacgat aaataaaacc ggtagaggat cctctaccgg 2376661 tttatcattt ttttgatcgc tccccaagct tcgtcttttc cctttttcgt ttctgaagaa 2376721 aagaggatca gctcgtcttc cggatcaata tttaatgttt gtcggacaac cttcgcgtgt 2376781 ttgtcccatt tacctttcgg gatcttatcc gcctttgtag cgataacaat aacaggaatg 2376841 ccgtaatact ttaaaaattc atacatctgt acatcatcat tagatggcgc atgccgcaaa 2376901 tcaacgatct gcaccacagc ttttaattcc tcgcgtgtcg tgatataggt ttcaatcatt 2376961 ctgccccatg cttcacgctc agactttgac actttggcaa aaccgtagcc cggcacatcc 2377021 acaaaatgca gctcatcatt gataatgtag aaattaagcg tttgtgtttt tcccggcttt 2377081 gatgacgttc tcgcaagatt tttgcgattg attaatgaat tgataaaaga cgattttcct 2377141 acgttcgatc ttccggccaa tgcgatttcc ggaagccccc cttcagggta ctgttccggt 2377201 tttactgcac tgatcacgat ttctgacttt gtgactttca tttcttctct cctactaagg 2377261 catgttccaa aacctcgtct aagtgggacg ccaatataaa tgtcagcccc tccctgacgc 2377321 tttccggaat atcctctata tctttttcat tatctttagg cgcaataatg gtcgttaatc 2377381 ccgctctatg tgcgccaagc gctttttcct ttaagccgcc gatcggcagc acgcgcccgc 2377441 gaagcgtgat ttccccagtc atgccgactt cacgcgaaac cgcccgtccc gttaaagcag 2377501 aaacaagcgc tgttgccatc gtaataccgg ctgacggacc atcttttggc accgcaccct 2377561 ctggtacatg tatatgaata tcatacttct catgaaagtc aggttcaatg ccaagttctt 2377621 ctgttttgga tcgcacatag ctgaatgcag cctgagcaga ctctctcata acatctccga 2377681 gctttcctgt caggattaat ttcccttttc ccggtgaaag cgatacttca atcgaaagcg 2377741 tatctccgcc aacggttgta tacgcaagcc ctgtcactac accaacttga tcctctgttt 2377801 cagcttgtcc atatctgaaa atgcgttttc cgataaaatc ttgaaggttc ttctcagtaa 2377861 ccgtaattcg ttttcgctct tcagcaacaa tggcttttgc agctttacgg caaattgcgg 2377921 caagctggcg ttcaaggctt cttacacccg cttctctcgt atagtaacga ataatatcaa 2377981 gaatcgcctg atcacgcagc tgaagattgc ttttcttcag cccgtgttct ttgatttgct 2378041 ttggaagcaa gtgatccttt acaatttcaa gtttttctat ttctgtgtag cctgcgatat 2378101 taataatttc cattctgtct ctgagcgggc ccgggattgt ggccaaattg ttcgccgttg 2378161 cgataaacag cactttggat aaatcaaagg tttcttcaat atagtgatca ctgaagctgc 2378221 tgttttgctc tggatcaagc acttcaagca tagcggatga tgggtctcct ctaaaatcag 2378281 atgacatttt gtcaatttcg tctaataaga agaccggatt cagcttgccc gcttttttca 2378341 tcccttgaat aatacgtcca ggcattgctc cgacataggt ccgtctgtgt ccgcgtatct 2378401 ctgattcatc ccgaactcct ccgagtgaga ttctgacgaa tttgcgtccc aagctttttg 2378461 caattgattt ggctaaagac gtttttccga cacctggagg tcctgccaaa cagagaatcg 2378521 ggcctttcag ggattttgtc agcttctgga cagccaaata ttctaaaata cgttctttta 2378581 ctttttcaag cccgtggtgc tcttcgtcca agagacgtcc tgcttctttc aaatcaagct 2378641 tatcatctgt ttcatccgtc cacggaagag caaccagcca gtcgatatag ttgcggatca 2378701 cagagctttc cgcagaactt gacggaattt tttcatatct gttcaattct ttaagcgctg 2378761 tttctttcac atgatcaggc atgcctgctt cttcgatttt ttccgtcagc gtctgaactt 2378821 cgccagtttt gccttcttta tcgccaagct ctttttggat cgccttcatt tgttcacgca 2378881 agtagtattc cttctgcgta cgctccatcg aacgtttgac gcgctggccg atttttttct 2378941 caatctccag cacttctttt tcattattaa taaaatcaat gaccttgttc agcctgtctt 2379001 tgacatcagc cgtttctaaa atatcctgct tatcctttag tttaaggggc agatgagaag 2379061 caacgatgtc tgccattctc cccggctctt cgatatcagt aaccgcagcg tacgtttcgg 2379121 ccgagatttt tttagaaatt tttatgtact gatcaaagtg gtctagcaaa gtccgcatca 2379181 atgcttcgtc ttctgtatct tttgaatcat cttcatgaat aagttgaatg tcaaccgacg 2379241 tgtaatcctc gtgttcattg tatttgacga tatgggcgcg cttgaggccc tccaccaaca 2379301 cacgaatcgt accgttcgga agcttcagca tttgcttaat ttttgtatag gtgccgacag 2379361 tgaaaatctc gtcttcacca ggttcgtcta tcgaaatatc ctgctgagtg gctaaaaata 2379421 tcatatgatc atgcatcatt gcctgttcaa gagcctgaac cgacttgtca cgtcctacat 2379481 ctaaatgcaa aaccatcgtc gggtacacta ataaacctct taaagggagg agcgggatgc 2379541 tgcgttttaa ttcttctgcc atgtgactga cacctccgtg actttagtat gaaccattat 2379601 aatacaactt tttcatcctt gtacaataaa cggcatggtt ccattttcta taaaacagtc 2379661 tcctcgtagt ataccctttc tttctgatat gaaaaaggaa aagatgtcct tcatgaaaaa 2379721 aaccctatta tcaaaatagg gtttaaacgg attctttatt gatttcgata tgaaacggtt 2379781 tttgttccgt tggcggattc accaaaattt catcaagcac ttcttggaac gtcttcactg 2379841 caataatctc gatcccgtca atctgcttta agatggcctg ctgattttca tatgggataa 2379901 tcaccttttt cgcaccggac tgcttggccg cttttatttt cggaatgacg cctccgatgg 2379961 gtttcacaag accgttcagg ctgatttcgc ccgtcatcgc aacggtattg tcaataggaa 2380021 ttttgtgtat cgccgagaaa atccccgccg ccatcgcaat gcctgctgac ggcccatcaa 2380081 tcggaatccc tcctgggaaa ttgatgtgaa tatcataatc agaaggcttc attcccattg 2380141 tccggagcac ggttaataca ttttcaaccg aacccttcgc catgcttttt cgcctgatcg 2380201 attttgattg gctgccgatg ctttcttctt cagctattcc tgtgatgtta attgatcctt 2380261 tatcttgagc cgcggttaca cttacttcga tttccagaag cgatccgctg ttaggcccat 2380321 agactgcaag cccatttaca atgccaacct gtggttcaac accgattttt tgctcgtgct 2380381 ttggagtaag ctgactggag tgaatgaccc attcaatatc ctcaatcgta atgtcctttc 2380441 gattctccgt tacagccatc cccgctgcga tttgaatcat attgacggct tcccgcccgt 2380501 tccgcgtgta gctggtcaaa agatccagtc cttcttcgga gatatttttt tcaattttat 2380561 ccgctgctgt tttggcaacc gttttcagct cgtccttttc aagctcgcgg aaaaaaacct 2380621 ccaaacagcg ggaccggata gctggcggaa tttcgtttgg cattctcgtg gtcgcgccaa 2380681 tcaagcgaaa atcagccggc agcccatttt gaaaaatatc atgaatatga ttcggaattt 2380741 gtgtattttc ctcactgtaa tacgcactgt ctaaaaagac ttttctgtcc tcaagcacct 2380801 tcagcatttt attcatttga ataggatgca gctcccctat ttcatcaata aacagcacac 2380861 cgccatgggc atgggtgaca gctccctgct tcggctgcgg aatcccagcc tgtcccatcg 2380921 ctccggcccc ttggtatatc gggtcatgga cagagccgat gagcggatcg gcaattcctc 2380981 tttcatcaaa acgggctgtt gtcgcatcga gttccacaaa gacagcctgc tctttaaacg 2381041 gtgattgttt atgttttttt gcttcttcca acacaagccg cgcagcagcc gttttcccaa 2381101 ctcccggtgg cccatagaca atcacatgct gaggatttgg cccgcataaa gccgccttta 2381161 atgctttaat gccgtcttcc tgtccgacga tatctttaaa gcttttgggg cggaccttct 2381221 cagataatgg ctcggacaag ctgatagcgc gcattttccg aagctgctcc atttccttct 2381281 ttgattcttt atctatcgtg accttttgtg tcctttgatt tttaagcaaa ttccaaaaat 2381341 acaaaccgat gatgatccca aaaaacagct gaataaataa cgcgatccct gtccaactca 2381401 tggtggtccc tcctgaaaaa caatttatgt atccaattca ttcctctgat tgctagtatc 2381461 tcccatagaa gacgggaata aacgtttttc cggaagagtt gcatgcaaaa aaacctcctg 2381521 agtgttacca ctcaggaggt ttgtgcttat ctttatgcag atgttttatc ttggcttacc 2381581 tcagtgccgt cttttaataa gaggcgagga ggctctccgt gtgtcacagt tgccccggtg 2381641 attacacatt tttcaatgtc atcacgagaa ggcagctcaa acatcacatc aagcatgatg 2381701 ccttcaatga tagaacggag tccgcgtgct ccagtcttgc gttcaattgc ttttttagca 2381761 atttcagaaa gcgcttcttc ttcaaactca agctcaacgt tgtcaagctc aagcattttc 2381821 ttgaattgct taacaagagc gtttttcggt tttgttaaga tcgcaaccaa tgcttcttcg 2381881 tcaagctttt caaggcttgc aataaccgga agacgtccga taaattcagg aattaacccg 2381941 aaacggagca aatcttctgg aagcactttt gaaagaagat cttctttctc aagatcagca 2382001 gctttattgt cggcaccgaa tccaatcact ttttggccta aacggcgttt gatgatttgt 2382061 tcgataccat cgaaagctcc gccgcaaatg aacaaaatat ttgttgtgtc aatttgaatg 2382121 aattcttgat gaggatgctt acgtccacct tgaggcggta cgcttgccac tgtaccctca 2382181 agaattttaa gcaatgcctg ctgtacaccc tcacctgaca catcacgtgt gatagacggg 2382241 ttttcagatt ttctagccac tttatcgatt tcatcaatat agataatgcc tttttcggct 2382301 ttttccacat cataatcagc agcttggatg agcttcaaga gaatattctc tacatcttca 2382361 cccacgtatc cagcttcagt caaagatgta gcgtccgcaa tcgcaaacgg cacatttaaa 2382421 atgcgagcca atgtttgcgc cagaagggtt ttaccgcttc ccgtagggcc gattaatgaa 2382481 atattacttt ttgaaagctc aacatcatca actttgctgt tggagttaat gcgcttatag 2382541 tggttataca cagcaacagc aagtgatttc ttcgcttgat cttggccgat gacatattca 2382601 ttcaaaattt cgcgaatttc ctgaggcttt ggtacgtctt taaattctac ttcttcttct 2382661 gttccgagtt cttcctctac aatttcagtg cagagttcga tacattcgtc acatatatat 2382721 acaccaggtc cagctacaag cttacgaacc tgatcttgtg tttttccaca gaacgagcat 2382781 tttaattgtc ctttttcctc gttaaattta aacattcttt caccccttaa tcttgtctca 2382841 ctttttcttt taccggcaga gcaaaagaaa atgattcttg aaacgaacga gtatgtattg 2382901 cattttacca tactttccaa aaagacggta acaatgtgtt tctgacttgc acattctata 2382961 tgtatgacaa aaaacagccc tgcattaact atattgcccc aagaaaaaga gataactcat 2383021 aattgtacaa aacaaggcac gaatgattcg cgccctgttt tattagtact attattatgc 2383081 accatattaa cggttttcta caagaaaatc aattgctttg cgaactttta aatcttcttt 2383141 catcgcgtca gtagaaccga tggcttgttt aatattttca acaggcatgt tgtatgcttc 2383201 agccattttt gtaagctcag catcaacttc ctcatctgat acttcaaggt tttccgcttt 2383261 cgcaatcgcc tcaagagtca ggttagattt tacgcgtttt tcagcatctt ctttcatttg 2383321 ctctttaagc gcagcttcat cttggcctga gaattgagtg taaagctcaa ggttcatgcc 2383381 ttgcatttgc agacgctgtt cgaattcttt cagcatgcgg tcaagctcag tgtcgaccat 2383441 tgcttgaggc acatcgattt cagcattttc agaagctttc agaacaagct cttcacgcaa 2383501 tttagcgtca gcttcgtttt cttttgcttc ttctaaacgt ttctttgttt tttcagttaa 2383561 ttcagcaagt gtttccactt cttcatcgat atcttttgcg aattcatcgt caagctcagg 2383621 aagctctttc gctttgattt cgtgaatttt cactttaaac acagctggtt tgcctgcaag 2383681 atcttcagcg tggtactcct cagggaatgt cacttcaaca tccttctcag cacctgcttc 2383741 aaggccaact aattgatctt cgaagccagg gatgaatgaa ccagaaccta cttctagaga 2383801 gtagttttca gcttttccgc cttcgaaagc ttcgccgtca acgaatcctt cgaaatcaag 2383861 aacaactgtg tttccttctt caacggcgcc ttcttctttt acaacaagct cagcttgacg 2383921 ctcttgaagg gcttttagtt cgttttgaac atcttcgtca gttacagttg tgtcgtcttt 2383981 ttcaatgccc aggcctttgt attcgccaag cttcacttca ggttttactg ttactttcgc 2384041 agtgaagatt aagctttcgc ctttttcgat tttttcaaca tcgatttcag gacggtctac 2384101 aggctcgatt ccagcttctt caaccgcttt agggtattct acaggaagaa gaatatccaa 2384161 agcatcttgg taaagagctt ctacgccaaa gcgctgttcg aataatccgc gaggaatttt 2384221 acctttacgg aatccaggaa ttgaaacttg ttttactact tttttaaatg catcatcaag 2384281 tgctgtttta aacgtttcag catcaacttc aaccgttaaa acgccttcgt tgccttcttg 2384341 tttttcccat tttacagaca tgtgtttccc tccaaaaatc tattcaggtt gtgtcggtct 2384401 tccattctaa agcaatcatt cggcttcgtc caacaaaaac aaagctgcca aagatcagaa 2384461 tcattatgta tagatgttaa taatgaactg caaagcctgt ccaaccgtat ttcttataac 2384521 ccgttataca caaatacaac cactatatta taacataaca catagcgctt tcaactatat 2384581 ggcgcgattt acaaataaga aatttcttca atatctttta acattgtgca agcttcatcg 2384641 agttctctgt ctgtaaattc atacatcata tgaagttctt cgctttcaat ttcaatcccg 2384701 tgcatctcgt aaccgacttt atgaagggca gccgcccaaa ggtcagccga cagcaatttc 2384761 ggctggaacg gatataaaac gtacaaatgt cttctccaca attcttctac tgctgcatat 2384821 aaggttggat tttcatttcc aagtgtctca tctagcaccc tgagaacacg gtgaagaatc 2384881 ggcgcggcat caggcggaac aatctctgac ggttcaattg tcaacgactc gccaaattta 2384941 ctaatgtgta caggtttact gtactcatgc tcagccaaca gcatgacaat catcgttttg 2385001 ataatcggat gggctgaggg gtcttggagg attgttttga gcaatcctgt atactttgct 2385061 acgttacggt cttttaagga atgaatgaga ttcatttgct cctcagggct tgccagcact 2385121 ttctcggtgt caattgtatc ctcatattct tcggcccaag cctcgtcctc acgatccgga 2385181 tcggtcattt tccggctgaa atccagcagc ttataaaatt gctcggcact ttctgccggc 2385241 agctgatttt cttccaaaac ggcttcaatg gtgcttttga cttcttcgta ctttttgagc 2385301 tgaattaaga tggtcatgta cacctgcaaa accgtaaaat aatggccata accttctttg 2385361 agcatcttct cgcacacgct ttctgcctct tccagctcgc ccagctctaa aaagcagatg 2385421 gccatcccta agtgaagatc ggattcagta tcatcatatt tcatcgcttc tgaaaacagt 2385481 tcaagcgctt cttgatactt tttttccttg agtgatgaca tccctttttc cacaaggcgg 2385541 tctttcagat gaggaaaagg aataattttt gcgtttttct tgtcatgcgt catacctata 2385601 ttcctttcag gcatttattt tgttcaagtg tatcaacacc tgtgaacaaa aacaagaaat 2385661 gaaaggtttc accaggcaaa aaaagccgcc ggacaaatac cggccgcttt ttcaggcttg 2385721 aagccaagag cttctttgtg attcaaattg cttgatttca tcttccagca gcagcgttaa 2385781 tgaaatttca tcatatccgt tgatcagcat ctctttccaa tgcggatcaa cttcaaatga 2385841 aatttgattg ccttcactgt catgaatcag ctgattttca aggtcaacag tcatttgcaa 2385901 tgactggttt tcatactggc cgacaagctg tttccaattg tcatatggca tgcggatcgg 2385961 aagcatgccg tttttaaagc agttctgatg gaaaatatca gcgaatgacg gcgcaatgat 2386021 aattttaaac ccataatcat caagtgccca cggagcgtgt tcacgcgatg acccgcagcc 2386081 gaagttttct cctgctatta aaatggaagc tccttgataa acaggctggt ttaattcaaa 2386141 ttcagggttc ggttcaccat tcgcatcata tctccagtca aagaatgcaa aacgtccgta 2386201 gcctgttctt tcaatcctct tcaaaaattg cttaggaata atctggtctg tatccacatt 2386261 gatccgattt aatacggctg ctttccccgt atgtgatttc aaaggttcca tctcgcgcac 2386321 tccttacaca actgtttttt cctgataaaa ctttctgaca tcaacgaagt gtccgtgaat 2386381 ggcagccatc gcagccattg ccgggctgac gagatgtgtt cttgcacctt ttccttgtct 2386441 gccctcgaag ttgcggttag aggttgatgc acagcgctct ccctcaggaa caacatcatt 2386501 attcatactc aaacacatgc tgcagcctga ctctctccat tcaaatccag cttccaagaa 2386561 aatctggtca agcccttctt tttcagcctg aagcttcacg ctttgggatc cgggcacgac 2386621 gatggccctt acgctgtcag ctaccttctt ccctttgatc atgtcagcag cctgtcgaag 2386681 gtcagtcatg cgggaatttg tgcaggaacc gataaatacg tgctccactt taatgtcttc 2386741 aattttttgg tgaggagtca atcccatata ttcataagca cgaatcgctt cttttttatc 2386801 gtcttctgca gaaaagcttt ccggcgcagg aacttcagaa tcgacaggaa gaaccattcc 2386861 cgggttaatg ccccatgtca ccatagggga aattttgttg ccgtcaagga cgatagattt 2386921 atcgtaaaca gcgcccgggt ctgtgcgcag cgccttccat tcctctacgg ccttgtcaaa 2386981 ttcttcgcct tttggcgtgt acttgcgatt tttgcaatat tcaaacgtca cctcgtcagg 2387041 tgcaatcaaa cctgctcttg ctcctgcttc aattgacatg ttacaaacag tcattcgttc 2387101 atccatcgtc atatttctga atacttcccc agtgtattca atgacgtagc ctgtgccgaa 2387161 tttcacaccg tatttgccga tgacagcaag gatgacatcc tttgccgtta cccctttttg 2387221 aagcgttcca tctacgcgca cttcaagtgt ttttggacgc tgctgccaaa gtgtctgtgt 2387281 ggaaaggaca tgttcaactt cactcgtccc gattccaaat gcaagagcgc cgaaagcgcc 2387341 atgtgttgat gtatgactgt caccgcacac aatcgttttc cctggaagcg ttaagcctag 2387401 ttcaggtccg acgacatgga caatcccttg atccacactg tgaagatcgg caaggcgcac 2387461 gccaaattcc tcacagtttc tttcaagcgc cgttacctgg cgtttcgcaa cttcatcctt 2387521 tatctcaaaa cgattgacag tcgggatgtt gtggtccatt gtcgcaaatg tgttttgggg 2387581 tcttctgacc tttcttccct tttgtctcaa gccttcaaat gcctgaggag acgtcacctc 2387641 atgaatgagg tgcaaatcaa tatagagaag atccggcttt ccctcaccat gttttacaat 2387701 atgctgatcc caaatctttt cgatgattgt tcgaggcatc atcttttatt tcctccctct 2387761 acctagagct aagaccgctt aacgtaagct gtcacacatt agaaattgta ttttcactca 2387821 tgattgctgc cttaacttcc tctgtaatgg cctgagtgct gctgaactct tcactccgtg 2387881 ccaagtctct tgttcttttt ccagaagcca agactttgtt taccgcatct tctacagctt 2387941 tcgcttcctc ttcaagcccg aaagatgttc tcaaaagcat tgccgctgac aatatggctg 2388001 cgaacggatt tgccatccct ttaccggcaa tatcaggcgc ggagccatga acaggttcaa 2388061 acagatgaag gccagagctt gataggctgg ctgacgggag cattccgagc gagcctgtaa 2388121 gcatggacgc ttcatcgctt aaaatatcac cgaacatatt ttcagtcacc acgacatcaa 2388181 attgattcgg tgcataaatt agctgcatgg ccgcgttatc cacaagcatg tgctcaagct 2388241 tcacatcagg aaattcttgt gcaacgtcct cagccacttc acgccacagc cggcttgatt 2388301 caagaacatt cgctttatct acagaggtca ctttgccttt tctggctgcc gccattttga 2388361 agccctctct gatcactcgt tcaatttccg ttcgcttata aaacagtgta tctactgctt 2388421 cctgctcacc ttcagtgttt acataacgtt tgctcggctg gccgaaatac aagccgcctg 2388481 tgagctcacg aacgataacg aaatcaacat tatctatata ttcttttttc aaaggcgaag 2388541 cgtcagaaag gctttcaaat accttcacag gccgcaaatt cgcaaacaaa tcaagctgtt 2388601 ttctgatgct gagcagccct ttttccggtc tcagttccga aggattttga tcccatttcg 2388661 gtccgccgac agcaccaagc aatatcgcgt ctgcattttt acaagcagca acggtttcct 2388721 ccgggagggg gttatgatgt tcatcaatag ccgcccctcc aatcaggcca tattcaaatt 2388781 caaattcatg gttaaagcgt tcggcaacac ttttcagtac gtctgtcgct gattctaata 2388841 cttcagggcc gatcccgtct ccgggcaata gagcaatacg tttcttcaag ttaaccgttc 2388901 tcctttcttt tatgatccga cagctgtgtg gtttttcaat ccgctcatat tcgactggaa 2388961 aaccaattga cggtttactg cgttcaaata ggctttcgct gatgcttcta atacgtcttg 2389021 cgctatgccc cgccctgctg attcttttcc gttcaccaaa actcttacat acacctgggc 2389081 aaatgcatct tcgccttttc tattagactg aatgcggtag tctaagagct ccacatcctt 2389141 atcgatgcag cgctcaagcg tattgtagat tgcttccacg cttccagctc cagttgcagc 2389201 ttcctgaata agctgtgcgt tttcttgatt tttcaaagat agagtagccg tagggacctg 2389261 acttgttccg taatgtactt gcagagaaag aaattcatac ccaatcttgc gatctgttac 2389321 tttttcttct aaaataagag aaacaagatc ctcatcagtg atttcttttt tcttctcagt 2389381 caactctttg aacatcgtaa agaatttatt aatctcttca ctgtcaaatt ggaatcctaa 2389441 agcagtcagc cggtctttaa atgcgtggcg tccggaatgt ttacctagga caagcgcatc 2389501 tgcggttacg ccgacaagct ccggtgaaat aatttcataa gtcgattttt cctttaaaaa 2389561 gccgtcctga tggatgcctg attcatgagc aaatgcatta tctccaacaa ccgctttgtt 2389621 gcgcgggaca gccatgcctg tcagtttgct tactaaatca cttgttctct taatctcgtt 2389681 cagcgtaata cctgtttcga cttggtagaa atcttttctg gtatggaggg ctacggcaat 2389741 ttcctctaat gccgcgtttc cggctctttc accgatcccg ttcacagcgc attcgatttg 2389801 atcagcgcca ttttcaatcg cagcaagaga gtttgcgact gccattccca aatcatcatg 2389861 acagtgggct gaaagctttg ctttgtgaat gttcggaacg ttttctttca tatatttaaa 2389921 gatatttccg tattccgccg gggccaggta gccgacagtg tccggaagat tgataacact 2389981 ggcgcctgcg tcaatcactt tctcgacgat ttctgctaga aacggcagtt cagtgcggca 2390041 ggcatcttca gctgaccatt gcacaatcgg aaaacgttct tttgcgtatt tcaccattcc 2390101 aactgctctt tcaatgactt gttcacgtgt cattttcagc ttgtgcttca aatgaatgtc 2390161 cgatgtcgcg ataaatacat gaattcttgg ttgagcgcca tcctttaacg cttcccaagc 2390221 agcatcaata tcacctttta cacaacgggc cagaccagtt actgaacaat ttttaatggt 2390281 tcttgcgatt tcctgaacag ctaaaaagtc acctcgggac gaagcgggaa atcccgcttc 2390341 aatgatgtct gccccgagtc tttcgagctg cttagctatg gcaagtttct cctgtgtatt 2390401 caagttcact ccaggggact gttcaccatc acgaagcgtc gtatcgaaaa aattaatttt 2390461 gcgcaacgga gaccaccgct tccttcttct tgccttgttt cacaaacggc atcatttcac 2390521 gaagctttct tcccactact tcgatttgat gttcgttctc gcttgcattg atagcgttga 2390581 aacgaggacg gtttacttgg ttttcgacga tccactcttt tgcgaatgta ccgttttgga 2390641 tatcttttaa tacttctttc atagattctt ttactttggc gtccacaacg cgagggcctg 2390701 atacgaaatc tccccactgt gctgtgtcag agattgaata tctcattcct gcaagtcctt 2390761 cttcgtacat aaggtctacg attaatttca gctcatgaag acactcgaag tatgcaagtt 2390821 caggctgata acctgcttca gttaaggttt caaatccggc tttgacaagc gcgcttaatc 2390881 cgccgcaaag aactgcttgc tcaccgaaca aatctgtttc tgtttcttct ttaaatgtcg 2390941 tttctaatac gcccgctctt gcgccgccga ttcctttagc ataagcgagg gctttgtctc 2391001 ttgcttctcc agtcacatct tgatagattg cgaacaatgc aggtacgcca gctccttgct 2391061 catatgttct tcttaccaag tgtcccgggc ctttaggggc cactaagaat acatctacat 2391121 ccgccggagg aacaatttga tggaaatgca cgttaaatcc atgagcgaat actaatgatt 2391181 ttcctgctgt caattcatct ttgatttcag cttcgtatac tttttgctgc tgctcatccg 2391241 gaagcagaac catgatgatt tcggcttggg ctgccgcttc ttttactgaa aatactttat 2391301 gtccgtcttc ttgggcttga gtgaaagatt ttccttgtct aacaccgacg atcacgtcta 2391361 ctccgctttc tttaaggttc agggcatgtg cgtggccttg cgaaccgtac ccgataaccg 2391421 ctactgtttt tccagccaat acgttctctt tgatatcacc gttataatat acttttacca 2391481 tttcaatctc tcccttgtta tgttttatac aatagatatt gttttattgg atgacgcctt 2391541 ttgctgggtt cccctcgcaa aagccgttgt acctgttctc gcgatttctt taatgccata 2391601 aggttttaat aactcaataa gcgcttcaat tttgttagat tcacctgtca cctgaacaac 2391661 gatgctgtct ctgctgacat caacgacaga ggctctaaac ggttctatga ttccattaat 2391721 ctctgttctt gttgaaggtg cggagacaac cttgattaag gccagctccc tctggacaat 2391781 cgattgattt gtgatgtctg tgactttcag cacatcaatc tgtttgttga gctgtttcgt 2391841 taactgttca acatcatttt caccttcaac atgaacgacg aaggtgattc tggaaacgcc 2391901 ggctgtttct gtgtgtccaa ctgtaatgct ttcaatgttg taatgccttt ttgtgaatag 2391961 accggtgatc cggtttaaca ccccggagcg gttcaccaca gtcaatgtga taattctttt 2392021 caaggtttca cccccaccat ttcatgcagc cctttccccg gagccaccat cgggaatact 2392081 ttttcttcgc tggcaacccg cacgtcaatg acaacaggtt ctcttgatgt taatgcctct 2392141 tccagctttt cctttgcttc cgcttctgat gaaattctga tgcctttaat gccgtatgct 2392201 tcggacaatt tgacgaagtc aggctgagaa gcgaatttag attctgaata acgttcttca 2392261 tagaaaattt cctgccactg tctgaccatt ccgagacaag cgttatttaa aatcactacc 2392321 ttgaccggaa gatttaattc gcgaataaca tcgagttctt gaagcgtcat ttggaatccg 2392381 ccgtctccga caaccgcgac aacagtagca tctttttcgg ccagctgtgc gccgatcgcc 2392441 gccggaagac cgaatcccat cgttccaagt ccgcctgacg tgacccattt atctgctttt 2392501 tggaacggat aaaattgcgc tgaccacatt tgatgctggc ctacatccgt tgcgacaatg 2392561 gcctctcctt ttgtaaattg atgaatatat tcaatcaatt tctgaggttt aaaaccttct 2392621 tcttcattat ctacatacca gagcggatac tcttctttcc attctgcgag ctgttttttc 2392681 cattcgcttg aatcgctttg tttgccgtct tgtttgatca gctcctgcag gacaattttg 2392741 ctgtctccga ctacaggaat ctgtgttttc atgatttttc cgatttcagc tggatcaata 2392801 tcgatgtggg ctatctttgc gtttctggca aagtgtttca ggtttcctgt gacacggtca 2392861 tcaaaacggg cgccgatact gattaataga tcacattcat gaagggccat attggctgta 2392921 taagtaccgt gcattcccgc catccctagg aaaagcggat ggtcagccgg gaagcctccg 2392981 agccccaaaa gggtgtgtgc cacagggatt tgctgctgtt cagcataatt ttttaattct 2393041 tctgacgctt ttccgtgcag tacgcccgca cccgccagga tcaccggttt tttcgcactg 2393101 ctcacggctt ccacaagctt gcggatctgc aaataattcg gctctgttgt cggctggtat 2393161 cccgggagat tcatctcatg atcgtagctg aattctcctt caattgttgc tacatctttc 2393221 ggaatatcaa tcaatacagg tccgggtctt ccagttgttg caatatggaa cgcttcttta 2393281 atgatgcgcg gcagatcttc cggctggcga acctggtagc tgtgttttgt tactggcatc 2393341 gtaatcccta aaatgtctgc ttcctgaaat gcatcgctcc cgattacaga ggttgctacc 2393401 tgccctgtaa agacgactaa cggcaatgaa tcaatcatgg catcagcaag gcctgtaaca 2393461 aggtttgtcg ctcccggccc tgacgtggca atgacgacac ccggttttcc ggagaccctt 2393521 gcgtatccct ccgctgcatg aattgctcct tgttcgtgac ggggaaggat atgtaccaac 2393581 cctgaattgt atagcttatc gtaaatcgga agcacagccc cgcccggata accgaagatc 2393641 atttctactt tctctttttt taatgattca atcagcatta atgctccgct catcgtctgt 2393701 gtacattcgg cagatgctga atccacctgt acattagtcc ccattttagt tcctcctttt 2393761 ggattttcat cctttaaaga tcatcttttc attagctaga tagctgatta ttcaataaaa 2393821 aaagcccttc cgcccacaat cagccgcgca gtaactgcga tagctaaaag gggcgaaaag 2393881 gcttttcttt ccgcggtacc acccttgttt acggcctgtt aatcggccgt ctcatggata 2393941 tttctatccg ctttagtaac gagtgaatca agttcacccg gccaagtcct actgtcattt 2394001 cagactggca ctctgaggcg agttcacctt gtaaagcttc gccggttctc agctaacccg 2394061 gttctctgtg gaaaacttta tcaaggctac ttatcctcat ctgcgctttt catattcagc 2394121 cttcggaacg gctttccagc tgttcaagaa ggtcgtttgt ttttcatttt tttagaatca 2394181 tactgcgatg attttcgctt gtgaagcttg catttatctt ttgttgaact catattacgc 2394241 cgctttggac gcagtgtcaa cagcattttt taaaattatt agacaatttt gattaatcaa 2394301 tctatattgt atacgctttc attattggta caaaaggaat tgcaaatgtt aaaagttttt 2394361 ataatttttt tattaatcta tcaagaatac accagaatta tttaatttta tataaacatg 2394421 gaagatttta taacacgata tggttcgtat atggattgag tctgacagat catcttgcaa 2394481 tccatttcaa tttcggatag gcacttctct tgttccctcg gcatacatta atgatatctt 2394541 gcaaagaaaa ggtgatacga tgaataaatc atttgcagac atgcaaggat ttcctgcggg 2394601 ctttccaagc ttccccaact ttccgcagca gtactatcct gctgtccctc ccttttacca 2394661 gcaaagccag cagccatttg gaggctacgg atacggacag ccgttcagtc aggcatacag 2394721 cccgttaacc actccctctg gaatgtactc ctcattccca tacgcttcag gattttacgg 2394781 acagcaattt tcaggtgcag gctttagcgg ccatggcggc agcttaagtg ctccagcgat 2394841 acatgccggc ggattcagcg gggcgccagg cgtacacgga ggctttagat attaaagaat 2394901 accacaaggg ccgaacatct attgcggtcc ttttattgtt ttaaaacgac ttcacaagta 2394961 cagtcacatt ttctgtcttt atatttggaa acaggatgga atatgattaa gatgaattga 2395021 acgatattct gcacaatccg taagttttcg aggaggaata aaattgcata taaaaataga 2395081 cgatttaact ggacgtcagg tggtttcact ggtgaatgag catttacata gcatgacgct 2395141 tatgtccccg ccagaaagca ttcatgcctt aggtctagaa aaactaagag ggcctgaaat 2395201 aacattttgg agcgcatggg aaggtgatga actagctggc tgcggagcgc taaaagaact 2395261 ggacacccgg catggagaaa tcaaatcaat gcgaacatct gcatcacatt taagaaaagg 2395321 cgttgccaaa caagttctcc agcacatcat tgaagaagcc gagaagcgag gctatgagcg 2395381 gttaagctta gaaacgggtt caatggcttc atttgagccg gcaagaaaat tgtatgaaag 2395441 cttcggtttc cagtattgtg aaccgtttgc agactacggt gaagatccaa acagtgtgtt 2395501 tatgacgaag aaattgtgag acggctttat aaggatagat aagtgcaggg gaaggtctgt 2395561 cttatctatc tttttttata ttcacacatt tttcaccttt atgatacacg ccaatgtttt 2395621 caattttgtt taattcaaag aacagcggga attacaaacg acatgaacga tatcatgcaa 2395681 attcataaag gaggagattg atatgaaaag catagttggt gtatatgaaa ctccgcagga 2395741 aaccatcgca gcgattgaag gcttacttac aaaaggctat gattctgatg acatttctgt 2395801 tgtgacaagc cggcgagata cagattattt ggagtcacgt acaggaacag aagtcaatca 2395861 agctatcgat gcacatcagg acgaatctga atcttttttc gataaactga aagattattt 2395921 cacaatggat gatactgcta cacacagcaa agcattatcc gacttggata ttaaaactga 2395981 tgaaatagac aagtatcaag aagatttgga tgacggaaaa cttctggtag ccgtcgatac 2396041 agatgcagat gtaattgctc ctattgataa cggcaatgcc ctttcaggcg gcttttcaag 2396101 cacaaatgaa ttggattata caacgaaaga agaaaaaacg atgccgctcc gggaagaaca 2396161 gctgaaggtc gataaggaag acgttcaaac cggcgaagta gaaataggaa aagaagtgaa 2396221 aacagaaaaa agagatatgg acattccggt gagacatgat gaaatttatg tcgaacgccg 2396281 tccagtggat gaaaataaaa cggacgctgc tcccgtcaac gattcggaag agatcagagt 2396341 tccaatcgtt gaggaaaagc tggaagtgac taaaaaaccg gttgtcactg atgaagtggt 2396401 tgtcggcaaa cgcactgttg aagaaaatga acatatttct gaaactgtga aaaaagaaga 2396461 acctcgtctg aataaagaag gaaaagttga cggcttggat gatgatccgt taaataacaa 2396521 atgaaaatca tagaccgaca acaaaaaacc tcaaatccta aatggatttg aggtttttct 2396581 tttggtacgt cccaggagag attcgaactc ccgaccgacg gcttagaagg ccgttgctct 2396641 atccagctga gctactggga cacgttttgt ttttttgttt ttcgctttaa ctatcagcga 2396701 caagatttat tatatatggg atgcaataat aagtcaacgg ttttttagaa tttttttcat 2396761 gaggaagaaa attttcttcc tcatgacatt ttcatagtgt gactcgattt tgcagatcct 2396821 caatttcatt gcctgcttgg tcgtaaaaac ggactgtcgc agcatcattt tctaatgtca 2396881 gtatagcata gctttctgtc ctgcgcaccc tcggaagccg gatgctgcct gggttaatca 2396941 tcagttttcc gcgcagcact tcgcttcccg cgatgtgcga atgcccgaag cagataacat 2397001 ccgccccgag ctcctctgca cgatagtata cgtttaacaa ggtctgtttt ataccgtgaa 2397061 ggtggccgtg tgtgactagt atttttcttg agccggcagt cagaagaagc tcgtccttaa 2397121 aatcgccggc aaaatcgcaa ttgcctttta caaccgcata aggctccaat gcaggatgcc 2397181 tcgtctcaag ctcagagtcc ccgcaatgaa tcatgagatc aacttctgcc tcatgccgtt 2397241 tcgcaatggt ttggagttct tcttcaagcc catggctgtc actgataatc agcacgttca 2397301 tgtacaagct tcctccttat gcctccaaaa gcttagacag ctttttaagc gcgtcagccc 2397361 tatggctgat tttatttttt tcatcacttg tcagttcagc catcgtctta tctttatctt 2397421 tcacgataaa aattgggtca tagccaaagc catattctcc tctcggttct tcagcaatat 2397481 acccttcaac atggccttcg actgtttttg tttcctctcc gggaatactc acggccagtg 2397541 cgcagcggaa acgggcggtg cgctgttctt tttcgatacc tttcagctcg ctgagcactt 2397601 tttcgatatt tgcctggtcg tctttctgtt cccctgcata gcgggctgaa taaaccccgg 2397661 gtctgccgcc aagattatcg atggatagtc cggagtcatc cgcaatcacc attttgttca 2397721 ctgctttggc aacagcttcc gctttcataa tggcattttc ttcaaatgta tggcctgttt 2397781 cttcaatttc ctctgtgaat ccaatttcag ctaaagattt gacatcatag cctcttggct 2397841 caagaatttc tttgaattcc ttcacttttc ccggattatg tgttgcaata attgcttctt 2397901 tcatgatgat caagcctttc tgtctttatt tcagttctgg cagagaatca cccagcactt 2397961 ctttttgctt gtcaatcagc tcttggattc ctttttccgc aagacccaga agaccgttca 2398021 gatcctctct agaaaaagtt gcctcttccc cggttccctg caattccaca aaacggccgc 2398081 tgcctgtcat gatgacattc atgtcaactt cagcagagga atcttcttca taatttaaat 2398141 ctaacaaaat tccctgttcc ttatcaattc caacagagat tgcagcaaga aaatcagtga 2398201 tcggatttgt cttgattgtt cctgctttga tcagcttgcc aatcgcaatc gccatagcaa 2398261 gaaatgcgcc tgtaatggaa gctgttctag ttcctccatc agcttgaatg acatcacagt 2398321 caatccaaat cgtccgttca ccgagctttt ccagatctac aacagctcga agcgcgcggc 2398381 cgatcaggcg ttggatctcc attgttctgc cggaaatttt ccccttagaa gattctctga 2398441 ttgttctttg gtttgttgcc cgcggcagca tgctgtactc tgctgtaatc cagcctttcc 2398501 ctccgccccg caaaaacggc ggtacgcggt cctcaacaga cgcgttgcag attacctttg 2398561 tatttcccgc tgttattaga acagaacctt ccggatggct gataaaatcc aaatcgaatg 2398621 tgattggacg cagctcatcg tgttgtcttc cgtcatgtct catgttttac ctccgattgt 2398681 atgtacataa accatttttg tcccggaatt gaataaagaa agaggcagcc ggaacgctaa 2398741 cctctttctt cctagtatat caaaaatccc aatttaaaaa ctacccgtat tcacttgaga 2398801 tggtctggag accggttctg tgagcttttc gcctttttca tttaccagct ctgattttcc 2398861 gttcacttta acagagacgc tttttacatc cggctgctcc gttaacgtca gcacaatgct 2398921 gttcagcact tctgaagaaa tcattttcgt cttctcatcg gcgctgccga atatagattg 2398981 attgaaatcc aacgtcacgc gcccgtcttt gattttcggt ttgctgacca gctttacatc 2399041 ttcactgaag tctgttaaca gcccgctcac cttgctcggc cctttagcca attcattaat 2399101 ggctgctgtg atgtcgtctt tttccgaatt gtcgattcgt ttggtcaccg gcacgtagta 2399161 ttcactgtct tcattttccg ccaaatagta gactgtcagc ggatgggtag cagtgagatc 2399221 atttacaccg gctgtttcca aattaatgcc gtctttgcgg cttaaatcat ctgagatcgg 2399281 cgtccctcct acaggcatct ccttcagttc atgcccgttt attctcagct tcactttatc 2399341 tatcgaacta aattgcgtca gcgtccacgt cacagattga acgattttct gttcgtcttc 2399401 tttcttataa tttttgaact cattagagaa atcagctatc gccgttccat cttttttgat 2399461 gtcaacgtta acggtggtgt cagccggcaa tacagctctg aagccattcg gaagaatttc 2399521 agacacaggc ccgccctgta cgaggtattc aagcgcctgc ttagccgtgc tctcactttt 2399581 aggaagaggc agcgtttgcg caacaacata cccgttttta tcaatgagat aaagctccct 2399641 cataacagta gatgaggctt gatccgcttt tgcggtatcg cttttttcac tttctgtttt 2399701 tttggctgct gttgtatttg aattggcacc cgcttcatcg ttcacgaatg taacgtcttg 2399761 aggcggatca atttcctcgg ctgccttatc agattgaaac aaaccgcatc cggataaaag 2399821 caaggcagag gtgagacaag tggcaccaat gactgcaggt ccttttttca gcatactttt 2399881 ccctcctaag gatgtttgta ctattatgta tacgagcctc tttaggaaat agaccgaaga 2399941 attccggcaa aacagaaaaa aacccgcaac ataccgttgc ggggaaaact atcttttaat 2400001 cggttcttgc agtgagatac attccacatg cccgacttca tggccaaacc aatcgtctgc 2400061 gatttttgca aactgatcac gcgcccctgt tgtcaggaac tgatgatccg gggcaatcgg 2400121 agactggttc agcagccctt tataagagag aattgtgctg acttcccggg ctgtttcatc 2400181 gccggacgaa ataatgttta cgtgctctcc catatatctt tgaatggctt cttttaaaat 2400241 agggtaatgg gtgcagccta aaatcagcga atcaattgat gtgtctttta acggatacag 2400301 cgaggtttta acaatctcgt ctgctgtttt gtcgagaaac ttcccgcttt ccacaaaagg 2400361 cacaagcagc gggcaggcaa ggttttcaac cttcaaatca gggtttaatg ccaaaagcgc 2400421 ttcttcgtat gcattgctct taatcgtatt ctctgtgccg atgacaccga tatgctgatt 2400481 atccgtcact tttatcgctg ctctcgcacc aggctggatg actccgacca ccggtatacc 2400541 gacgctgcgc tggatgtcat ccaaagcgat cgctgttgct gtattacagg cgatcacgag 2400601 cattttgatg tggtggtttt cgagtaaata attcgtcagc tcccacgtat attgaagcac 2400661 ctcttcttca gggcgcggcc cgtaaggaca ccgtttcgta tccccgacgt agataatatt 2400721 ttctttaggt agctgtctca tgatttcctt cgcaacggtt aaaccgccaa ccccggaatc 2400781 aatgactcct attggttgtt ccaacaaaat cgcctcattt tctcttcatt tcatgctgca 2400841 gtttcatcaa agatttttcg aagatggcta tttcttcatc tgtaaacgat tcgaacatat 2400901 cacgcagata ttcctgtctt tttgtaatga cctcttggat aatccgttct ccttcaggca 2400961 gcagatgtat cctgacaaca cgtctgtccg ccgggtcctt gacccgctca acaagctcat 2401021 ttttttgcat gcggtcgatt aagtccgttg tcgtgctgca tgccagatac attttgcccg 2401081 ataattcacc gattgtcata tctcctaatt cataaagcca ttgcaagccg acaaattgcg 2401141 gcggcgtaat cgcatattgg ttaaggattt ctcgtccttt ttgcttaatg atcgcggcaa 2401201 tgtggcggag tgacttttca atatccgcaa catgctccaa aggttttgat gtcatttgtc 2401261 catccctcac tcaaggatct cttacgcaca aaagcgttcc gtgtctattt tccttctttt 2401321 ttgaagaaaa tgcaagactc gcaggagaga aatagaggac tttagtcaaa caacatcaag 2401381 aaataaaatt taatttatga cttgcctacg ttttgcacag cattccaaat atggtttcga 2401441 atgttccaaa caaacagcaa taaccggctc cttccaaaag aaggaatacc ggcaaggatt 2401501 aaagctctag ctcacccatt ctaagaagct caacaacggc ttgcgaacgc cctttcacac 2401561 ccaatttctg catggcattt gaaatatggt ttcgaacggt tttctcactg ataaatagct 2401621 cgcttgcaat ctcctttgtt gtcttatctt gaacgagcaa ttcgaacact tctctttctc 2401681 ttttcgttag cagcggcttc gattgaaatt ctttctcctt caagtattgt aaccctcctt 2401741 gctaaggtga gagcgaatca gaaacgaatg ggttttgata tagtcgagat atcatatgta 2401801 agaagggcgc aggaggtgac gtttacaaga taattagttt atcgtgtatg aagaagcgtt 2401861 tctttctcct catccgtcca gctgacagcc ttgccgcttt cctttgagac ttgaaccatc 2401921 acgactgccc cggtgaagca gggttcgcct tcgaggttct ctccgagata gtgcaaggta 2401981 agagatgaac tgccgactgc gcttgttttc acatagatgc gcaactcttc ataaggcatg 2402041 acttggcgca aataatcgca ttgctggctt gccacgactg tcatggtctg tttgttttca 2402101 ctcatcatat tcagcttttt aaaataagaa atccgcacct cctcaaaata tataaaaggg 2402161 gttacattat tcatatgccc aaacatgtct gtctcggaaa atcttacgga taccttattg 2402221 aaaaaagaaa aggatgtttt ccattcttga aacggcatat caatataagc gggaagcttc 2402281 atcttttttc atctccttat tgtttaaaaa aacctctccc atgcggaaga ggttttttct 2402341 tcttatactc tgtcgcttcc gaagaaattg cggaacgctt gtaagtttgt atctctattc 2402401 aaggctgcaa tcgaagtggt aagcggaatc cccttcggac aggattgaac acagttttgc 2402461 gagttgccgc aatctgcaag gccgccttca tccattaatg cttctaatcg ttcagattta 2402521 ttcatggcgc ctgtcggatg cgcgttaaac aggcggactt gcgacatcgg tgcaggcccc 2402581 atgaacttcg atttgctgtt cacattcggg caagcttcga ggcagacgcc gcatgtcatg 2402641 cattttgata attcatatgc ccattgacga cgtttttccg gcattctcgg ccccggtcct 2402701 aaatcgtacg taccgtcaat cggtatccac gcttttactt ttttcaatga atcaaacatt 2402761 ctgctgcgat caacctgcaa atcacgaacg actgggaatg ttttcattgg ttttaaacgg 2402821 attggctgtt caagctggtc aataagcgcc gtacaagact ggcggggttt tccgtttata 2402881 accattgaac atgcgccgca tacttcctca agacagttca tatcccatgt gacaggggtt 2402941 gtcttctcac ctttgacatt aaccggattc cggcggattt ccatcagagc ggaaatgacg 2403001 ttcagattcg ggcggtatgg aatctcaaat tcttcatcat aaggcgtgct gtcagctgta 2403061 tcttgacgtg tgataataaa tcgtatggtt ttttgttcac tcatgattat ttcgccacct 2403121 tcttcttcga gtaatcccgt ttccgaggcg ttatcagtga tacatcgaca tcctgatact 2403181 caaattccgg cgcttcatac gggcttacat gtttagccat tgttgttttg agccattcat 2403241 catcattacg ttcaggataa tccggtttat aatgggcgcc ccggctttca ttacggttgt 2403301 atgcgccaag ggtaatcacc ctcgcaagct gaagcatgtt cgagaactgg cgtgtgaaca 2403361 tcgctccctg gttgctccat tttgtcgtgt cattgatgtt gatctttttg aagcgctcca 2403421 ttaactcctg aattttgtca tccgttttca aaagcttgtc attatggcgg acaaccgtta 2403481 cgttcgccgt catccactca ccgagctctt tgtgaagaac ataggcattt tcggttccgt 2403541 ccatactcat aatatcagcc catttttctt cttctttctt aacgtgagcg tcgaataaag 2403601 atgaagacat gtcttccgct gaagattcta agccgtttac atatttcacc gcattcggac 2403661 cggccaccat gcctccgtaa atcgcagaca gcagggagtt cgctcccaag cggttgccgc 2403721 cgtgcataga ataatcacat tccccagccg caaacagtcc agggatattt gtcatttgat 2403781 cgtaatccac ccataaaccg cccatagaat aatggaccgc cgggaagatt ttcattggaa 2403841 gcttacgcgg gtcgtctccc atgaatttct cataaatctc aatgatgccg ccaagcttaa 2403901 tatcaagctc tttcggatct ttatgagaca gatcgagata taccatgttt tcaccgttaa 2403961 taccgagctt ctggttcaca cacacatcaa atatttcgcg tgtcgcaata tcacgcggca 2404021 ccaggtttcc gtatgccgga tatttttcct ccaggaaata ccatggtttg ccgtctttat 2404081 atgtccacac gcgcccgcct tcaccacgcg ctgattcact catcagtctt agtttgtcat 2404141 cgcccggtat ggctgtcggg tggatttgaa tgaattctcc gtttgcataa tacgctccct 2404201 gctgataaac gattgacgca gcagatcctg tattaatcat ggagttcgtt gattttccaa 2404261 agatgattcc cggtccgccc gtcgccataa tgacagcgtc tgaacggaag gattcaattt 2404321 gcatgtttgt caggttttgt gcaacaattc cgcggcaggt tctgtcatca tctaaaacag 2404381 cgccaaggaa ttcccagcct tcgtattttg tgaccagacc cgcaacttcg tatctgcgca 2404441 cttgctcgtc cagtgcgtaa agcagctgct gtcccgtcgt cgcaccagca taagcagttc 2404501 tgtggtgctg tgtacccccg aatcggcgga aatcaagcag gccttcaggc gtccggttaa 2404561 acatgacgcc catccggtct aataagtgga tgatcgaagg cgccgcttca cacatcgcct 2404621 tgaccggcgg ctggttggca agaaagtctc ccccgtatac cgtgtcatca aaatgttccc 2404681 acggagagtc accttcccct tttgtattga ccgctccgtt tatgccgcct tgcgcacaaa 2404741 ctgaatgaga acgtttgaca ggaacgatgg aaaacaattt aaccgccatt cctgattccg 2404801 ctgctttaat tgtcgccatg aggccggcaa gacccccgcc gactacgata atgcttgatt 2404861 gactcatgat agcccctctc cctctagtaa tctagtactc ttaaacaaat gcaaaaatcg 2404921 cttttaagcc tacgtatgac agtgcaacaa aaataatcag cgtaacgtat gtcgaaattc 2404981 tttgagaacg aggcgttacc gtgatgcccc atgtaacagc gaaagaccat aaaccgttcg 2405041 agaagtggaa aattgttgat aaaacaccga caatgtaaaa accaagcata gccggagagc 2405101 tcaaaatatt cgccatcatg tcgaaattga cctcagcacc catttgtgcg gcaatgcggg 2405161 tttcccacac gtgccagctg acgaaaatga gggtgatgat accggttaca cgctgcagga 2405221 cgaatagcca gtttctcatg tagctgtatt gaccggcgtt atttttcgca gtaaacgcta 2405281 tgtacacacc ataaactgca tgataaatta atggtaagaa gataataaaa atttccaagg 2405341 catacctgaa aggcaggcta tccataaaat gagcagcgct attgaatgct tcagcgcccc 2405401 ttgcggcaaa ctggttgacg actaaatgct gaataagaaa gatgccgacc ggtatgacgc 2405461 caagcaagga atgcaatctt cgaaaataaa actctctgtt cccagacatt actttacccc 2405521 ctgtttgata agtgcgaaat gtgctaaatc tcttccccca cttctttcaa ttgtaagcac 2405581 tttattaaga tttattgaca atttcatttt actcctccct caaaagggcg tcaagaaaac 2405641 gcgtacataa attataattt tccgaattga ttagttgatt gaaaaatttt attttatcaa 2405701 tatatatttc ttgcttaatt tttcataaga attacaggat cattctgtaa tcctcccccc 2405761 tgtttgagct ataatatacg caggagagag gggagacaga tatgaagtct aaatttgaag 2405821 catctattga caacctaaaa gaaattgaaa tgaacgctta tgcctacgaa ctaatacgag 2405881 agatcgttct cccagatatg cttggccaag attactcttc catgatgtat tgggcaggaa 2405941 aacatctcgc ccgtaagttt cctcttgaat catgggagga atttccggcc ttctttgaag 2406001 aagcgggctg gggaaccctc accaacgtaa gcgctaaaaa acaggagctt gaatttgaac 2406061 ttgaagggcc gatcatttcc aaccggctta agcatcagaa agaaccttgc tttcagctgg 2406121 aggctggttt tatcgctgaa caaattcaat tgatgaatga tcagattgcc gaatcatatg 2406181 aacaagtgaa aaagagagcc gataaagtgg ttctgactgt gaaatgggat atgaaagacc 2406241 cagtgtaatc aaaaaggcgg tgactgcata gtcccgcctt tttgattgtc attacacagc 2406301 tgaagggtgt tttgaaagct caaatgcatc gtgaagcgac tcgactgctt tcaccatgtc 2406361 attttcgctt acgactgttg acactttgat ttcagatgtg ctgaccattt tgattaaaat 2406421 gtttttttgc gccagtacag caaacatttc agccgctaca ccgggatttg agaccatgcc 2406481 ggatccaaca atagatactt tagccaattt gctttctgtc tcgattttct caaattccag 2406541 cgcgtcttta tactcttcaa gcaccgcaac ggtttggtct gcatcttctg ttttgacaga 2406601 gaaggaaatt ccagtcttgt cctcggcctg cgtttggata atgatatcca cgtttatgtt 2406661 tcttttggca agtgttgtaa aaatagtaga caaagttgtc aggccgctag tcagcccgta 2406721 aatggttact cttgtgattt gatcttcaaa tgcaatgcct ctgacaatta aattctgttc 2406781 catggatgat tcctcctcaa ttaatgttcc cgcttcggtt tctgtacttg aacgcacttc 2406841 taacggcact tggtaatttt tcgcgaactc aactgctctc ggatgaagaa caccggcgcc 2406901 taaattggca agctcaagca tttcatcgta tgagatgccc tcaagttttc tcgctgattt 2406961 cacatagcgc ggatcggttg taaacacgcc tggcacgtct gtgtatatgt cacatttatc 2407021 agcttttaaa gcggcagcca aagcaactgc tgttgtatct gaaccgcccc ggcccaatgt 2407081 cgtaatttca caatcctctg tcatgccttg gaatcctgca acaatgacaa tttttccttt 2407141 ttcaagctgg tctgctaaaa ccgaagtgtc gatatctgta attctggcgt ttccgtgaat 2407201 ggcctccgta cggattcccg cctgccagcc agtataagac acagcgtcat agcctttttc 2407261 ctgcaatgcc attgaaagga gtgaaatcgt gacctgctcg cctgtcgcca gcagcatatc 2407321 catttcgcgt ttgctcggct ggtcagaaat agcttttgca aggctgacca attcgtcagt 2407381 ggattttccc attgctgaaa cgacgacaac gacttgatgg cctttctgtt tttctgcaat 2407441 tgcgcggttt gccgcatttt gaattttttc gactgagccg acggaagtgc ctccgaattt 2407501 ttgtacaata agacccatgt attaccaccc tttacatttt ggttcgtgcg ggtgaggaga 2407561 aagagcgctt tgtccacaat aaaaaaagca atgagaggaa tactctcatt gcttatcaat 2407621 taatcatcat aaatgattat gaacaacgag atagccctcc aagaaaatga tttcttgaca 2407681 gccttacatt tattcaatgc acggccagca aataataccg atggggtttt atttgcttcg 2407741 gcgacgctcc cctttcagcc tttttcacag aatccatctt tctccaaagg catactcttg 2407801 aagttcgcac ctctatcttc accatataac acgatctaac tatgaaatta gttcacattt 2407861 tatcagatct tatttaaaag gacaacatta tttttgcaat ttgtcgtaaa ggagctgagc 2407921 cgccgctgcg ggaacaccgg cttttttgat gtcctcaagg cttgcttcct tcattttttt 2407981 aacggaaccg aaatgcttta acagcatttt ctttcttttc tctccgatac ccgggatgtc 2408041 gtccaaaacg gattgaaacg cgctttttcc ccggatttgc ctgtgaaaac tgattgcaaa 2408101 acggtgcacc tcgtcctgaa tgcgctgcag gaggtaaaat tcctggctgt ttcgttccag 2408161 atacgccacc tccagcggat caccgatcag taaatttgag gttctgtgtt tttcatcttt 2408221 cgctaaaccg gcgatcggga tatccaagcc gagttcattt tcaatgacat cccttgctgc 2408281 gttgatctgc ccttttcctc cgtcaatgat aatcagatcg ggcagcggca gattctcacg 2408341 aagcactctc gtatagcgtc ttctgacaac ctctctcata gaaccgtaat catccggccc 2408401 tgtaacagtt ttgattttat atttgcggta ttcctttttg tatggtttgc catcgataaa 2408461 cacaatcatc gcggaaaccg ggtttgtccc ctgtatattt gagttatcaa acgcttcaat 2408521 tctgtgcggc gtataaatat ttaatgcctc acctagtttc tgcactgccc cgattgaacg 2408581 ctcctcgtcc cgttcgatta aagagaattt ttctttcaat gcgattttcg catttttatg 2408641 ggcaagcatg agcagttctt ttttcgggcc ttttttcggc tggtgaacgt ttgtttccag 2408701 tagctgctcg atcatagatt gatctatgct gtccggaact aaaatctcct tcggaaggaa 2408761 gtggttgttt tttgaataga actgcccgat gaacgtgagg aactcttcat ctgcttcctg 2408821 ataaagcggg aacatgctga catcgcgttc aatgagcttt ccttggcgga tgaaaaagac 2408881 ctgcacgcac atccagccct tatcgtacgc gtacgcgaac acatcacggt cgactagatc 2408941 gttcatcgtc attttttgtt tttccatcgt tgattcaata tgggcaattt ggtcacgaag 2409001 ctcttttgct cgttcaaact caagattctc agcagcttca tgcattttct cttcaagctc 2409061 ttttttgacc tcattatagc cgccccttaa gaaacgtgta atgctttcaa ccagctctct 2409121 gttcgtctct tcggaaatat cctttacaca cggagcaagg cattggccca gatgatagta 2409181 aaggcacact ctgtccggga gcttggagca ttttctgaga ggatacagac ggtcgagcag 2409241 tttttttgtt tcccttgctg cctgtacatt cggatacggc ccgaaatagc gccctttgtc 2409301 ttttttgaca ttgcgggtga caatcagcct tgggtggcgt tcatgggtga gttttatgaa 2409361 aggataggtt ttgtcgtctt tgagcatgac gttgtatttc ggatcatgct ttttgatcag 2409421 attcatttct aaaataagcg cttcaagatt ggaggacgtc acaatatatt caaaatcctc 2409481 gatttccgtc acaagccttt gggttttcgc gtcgtgagaa ccggtgaagt aggagcgcac 2409541 tctgtttttc agcacttttg ctttccctac gtagatcaca gtctgctgcc ggtccttcat 2409601 gagataacaa cccggttgat caggaaggag ggcgagtttt tctttcagtt gtttgttcat 2409661 atgttaccct tccttatgtt taatccttta tttccagttt aacacgaacg tttgtttttc 2409721 tctatggttc acaattggcg aataaaaaaa gcgatccctc aatcggaatc gctctggcat 2409781 gtaagcagcg gaaaattaaa gatgtttgtt tacaagctct tgaagcgctt cttttggttt 2409841 gaagccgact gaagtttcaa ctacttcgcc gtcttttaac acaagaagag tcgggatgct 2409901 cataacgccg tattttccgg cagtttcttg gttttcgtct acatcgattt ttacgatttt 2409961 cagtttgtct cccatttctt gatccaattc ttcaagaaca ggtgcaatca ttttacaagg 2410021 tccgcaccaa ggagcccaga agtctgccag tacgacgcct tcgcttgttt cagctgagaa 2410081 agattgatca gttgctttta cgatagccat tattgaattc ctccaatgtg aaatgatgat 2410141 ttttagtata gcatctccca ttcgttcacg ctattttaat gcttacaaat tattttttcc 2410201 tgatcacagc cggtttactc atttttatat ggttgaatgg gatatgctct ttttttaaaa 2410261 cacaaatctg ataatggccc cgatcactac aattgcccca ataatcatta aaatggtacg 2410321 aagcataaga tcacatctcc tcttcactgt catgtacttt accatgccct gccggagctg 2410381 ttttaaaacc tgaaaaagag cgccggcatg aagctccggc gctcttgcgc gattaagaat 2410441 cagcacgcag cgtaagtaag acgactgaca ttggcgggag ttttactttc agtttgtttt 2410501 tgctgagcgt gtattgtctg aaggattccg gtttgacatg atgaggatcg tcaaacgtgt 2410561 tatgcgcatt cattttttct gccgtaagaa tgactccgga atggtccgct gccttgtgta 2410621 ggcccctcag ctcgatttcc gcctctgctt tgttttggtg atcgatgttg caaattgtga 2410681 tattgatatc gccttcagct tgtttcgacg ctgaaatgct gatttgcgga agcgtttcac 2410741 cgttccattc atagtcggca gacattgtct ctgtggctaa aagagaagcg tcctggtgca 2410801 ccttaaacat attgaataca tggtacgtcg gtgtcaaaag catccgctct ccctcagtca 2410861 aaatcatcgc ttgaagaaca tttactgttt gggcgatgtt ggccatttgc acccggcggc 2410921 aatgctgatg gaaaatgtgg aaatgagaag ccgccaccag tgcatcacga atggtgtttt 2410981 gctgatataa gaaaccggga ttcgtgcctg gctcgggatc aaaccacgtg ccccattcat 2411041 caataatcag cccgacccgc tgctccggat cgtaccggtc cataatcgtg ccgtgttttt 2411101 gaatcaattc atcgatgtat ttggcttttt tcatcgtaat aaaccattca tcttccgtga 2411161 attctgtggc tgatcctttg cccttccaga aatcccccgg aatcgtgtaa taatgaagac 2411221 tcaacccgtc catcaggcca gcggcttttt tcataagcac gtccgtccaa ttaaaatcat 2411281 ccacatttgc gccgcctgca attttataaa tgtcattccc gctgtaattg cggacataag 2411341 tctgaaaacg ccggtacaga tctgcgtagt attcgggatg catgttgccg ccgcagcccc 2411401 agttttcatt gcccacgccg aaatatttca gcttccaagg ctcttctctt ccattttgct 2411461 ttctccagtc tgacatcggc gtgccttctt caaatgtcat atactcaatc cactccgaca 2411521 tttcctgaac ggttccgctt ccgacattgc cgcaaatata tggctcgcat tcaagcagct 2411581 cgcaaagcat cataaattca tgcgttccga attcatttga ttcaattgta ccgccccagt 2411641 gagtgttcag cattgtctta cggtcaccga caccgtttgc ccaatggtat tcgtccgcaa 2411701 aacacccgcc cggccaccta aggacaggaa tgtgcagctg tttgagcgcc tccagcacgt 2411761 cctttcgtat cccgttgata ttggggatgt ctgagtccgt tccgacccag atcccctcat 2411821 aaatccctct tcctaaatgc tcagcaaaat gaccgtatat atttttgtta atggttcctt 2411881 ttgcgatatc tgtttgaatc actgcttgat gttcagacat gcctctgatc attcctttca 2411941 tacggatatg aaaagcacca cagtcaaata tgtgatctgt cgtttgcctg aggagtcagc 2412001 atgaatgtaa gcgcttttaa agtaaccata ttatatatgt tcgtacatgt caacgacatt 2412061 ttctattgtt tttatatttg tacgtatgta tttataaata tgaaaaaacc cggactttta 2412121 aagtccggga tttcctttat gagtgtatat tcagctgttt gaattcctca gttaataacg 2412181 ggacaacttc aaataaatca ccgacgatgc cgtaatccgc tattttaaag atatcggctt 2412241 cggggtcttt attgatggcg acgatcacct tgctgtttga catgccggcc aaatgctgga 2412301 tggcgccgga aatgccgcat gcaatgtaca aatccggagt aacgactttc ccggtctgcc 2412361 cgatttggag agcataatcg caataatcag cgtcacatgc cccgcgagaa gccccgactg 2412421 cggcccctag cacctctgca agctcctgca gcggctgaaa tccttccttg cttttgactc 2412481 ctcggccgcc cgcaacgata attttcgctt cggagagatc aacaccgtcc gccgtttttt 2412541 tcacgacctc ttggataaca gtgcggaggt cagtaagaga aacatcaatg ctttcgatgc 2412601 tccccgatct gctggtgtct ttttctgaag cttgaatgtt attggggcga attgttgcaa 2412661 agatcatcgg atcggttgaa atgacgcgtt caaaagcttt ccccgagtaa atcggccgtg 2412721 tgaacacaac attccctccg gtaacgctta catctatagc atcagaaatt aagcctgttt 2412781 gcagacgggc agcaagcttc ggtgaaagat ccttgcccat tgccgtatgc ccgaagatga 2412841 ctgaatcagg attttcttgc tcgataacac ctctcatgac ctggctgtac ccgtctgccg 2412901 tgtatgtttt cagcttcggg tcctcagcgg taagaacttt atctgctccg taatgaataa 2412961 gctcttgtgc aatgctttgt acattttcac cgatgagaac accgatgact tccccatctc 2413021 ctgaaatggt tcttcctgca gctattgctt caaaggtgac atttcgcaat tccccatcgc 2413081 gtatttctcc aagcacgatc actttttttc ccattctaac atccccctgt ttctttgaat 2413141 gtccaagttt taaatgactt tagcttcgct gcggagcaat gaaacaagct cttttgcctg 2413201 ttcagcaggc tcaccttgga gaagcttccc ggcttctttt ttcggcggca gaaaacgttc 2413261 aatggttttc agctttggtt cagcatcctc ttcgtccaga tcaagatcat caagttcaag 2413321 ctcttcaagc ggctttttct tagccttcat aattcccgga agcgatggat agcgcggctc 2413381 gtttaagccc tgctgagctg tgacaagcaa tgggagcgtc gttttgattt tttcaacatc 2413441 cccttcgacg tccctttctg cttctgcatc agtgccgttg atttcgagtt tggtgatcgt 2413501 agtgatacac ggaatgtcca gtagctcggc aagccgaggc gccacttgtc ctgatcctcc 2413561 gtcaatggca acatttccgc cgagaatcaa atcaaactcc tgatccttca tatagtggta 2413621 taaaacttga gaaatggaat attggtcggg ttcatcaaga tcatcttcta tgttgattaa 2413681 aacagcttgg tcacaaccca tggcaagcgc cgtacgcaat tctttctccg cttcttcacc 2413741 gccgaccgtg acagcggtga tcgtgccgcc atgcttttcc ttcagctgga tggcttcttc 2413801 tatcgcgtac tcatcatatg gattaatgat ccattccgct ccgtcatcct gaatctttcc 2413861 tgtttcaatg acgatttttt cttctgtgtc aaacgtccgt ttcatcagta caaatagatt 2413921 catgatcata tcccctttta ttcgcctttg aactgaggct ttcttttttc gagaaatgcc 2413981 tggatgcctt ccttggcgtc ctctgactca aatgcttccc caaatcgctt tgcttcaagc 2414041 tttaagctgc cttcatagga atacaccttg ttggaataaa gaagttcaag caaagatgcc 2414101 agcgtttgcg ggcttttctc tgcaaactta gcggcaagtg cttttgcttt ttcaatcact 2414161 tctgcctcat ctttcgctcc aattgagaca agtccgagat caagcgcttc ttttccggat 2414221 atcggttctc ctgatccgat gagctccagt gctttggctg taccgacata tctcggaagg 2414281 cgctgtgtcc ccgcaaaacc tggaatgata ccgagattaa gctccgggag ccccagctta 2414341 gcatcttctg ccgcgattct gatgtgacag gccattgcaa gctccagccc gcctccgaga 2414401 gcagcgccgt gaatcgctgc gataatcggt tttggaaaac tttcgattct ctccattaac 2414461 tgctggccgc gctcagcgag caatgaggaa tcctcattgc ctttaagcga tgtaaattct 2414521 ttaatatcag cgccggctga gaaaaatctt ccctcgccgt gaatgataat gcttcgtacg 2414581 cctgcatctg tctcacattg atcaagacag gaagacagct cttctaatat ccggcttgaa 2414641 agcgcgtttg ccggcggatt gtgaatcgtc aagactgcca caaattgatc aaccgcaagt 2414701 gaaattgcat tcataggaca gaactccttt acttattgtg aattccggat accaataatt 2414761 ctaaaacgct gtttgaaagc gcaacgagat cgtacttttg gtcattcatc acccaagttg 2414821 tcacagtttc gtcaatcgtt ccaaaaatca tctgccgggc gaggcggaca tcgaggcctt 2414881 cttttatttc gcctgattgt ataccttccg tcaaaatgcc atccaaaata tttaagtagc 2414941 cttttaatat ttcgttgatt ttttggcgca gctccaagtt ggattggcgg agctcaagct 2415001 gcgtgacaat ggcgagatta tggtcacccg ctaaaaggga aaaatgcttt gaaatcacaa 2415061 gcgccaattt ctctttcgct gttgcttttt ctttaatgtc ctcttccatc cgctcaataa 2415121 attgacccat tttttctttg aaaagagaaa ttaaaatatc ttctttgttt ttaaaataga 2415181 gatagatggt gccgtccgct accccggctt gtttggcaat tttggatacc tgtgactggt 2415241 ggtagccgtt ttctgcaatg acttctactg ctgcatcaat aatctgcata tactttggcc 2415301 gtttttgctt caatgttcat cgttccttcc tatagaaatg aatgactatt cattcataat 2415361 ttcatgataa gaaggatttt caggtttgtc aagtttattc ataggcgttc tcttttttta 2415421 tttgatatga tgattttcgg tttcttcttc aagtaaacgc cttcttaaaa tttttcccac 2415481 cgccgttttc ggcagctcct ttctgaactc ataggctttg ggcaccttat agggagctag 2415541 acgtgatctc gcaaaagcgt ccagttcttc tgtatcggct tttgcgcctt tctttaatac 2415601 gacaaatgct tttactgttt ctcccctgta ggaatcggga acgcctgcga caacaatttc 2415661 ctggatggct tcatgttcat aaagcgcttc ttctacctca cgcgggtaaa tattgtaacc 2415721 gccggcaatg atgatatcct tcttcctgtc agcaatatag aaaaagcctt cttcatccat 2415781 atagcccatg tccccggtga acagccagcc atctctcagc actgcggcgg tttcctctgg 2415841 tttattccag tatcctttca tgacttgcgg accttttaca atgatttctc catgctcata 2415901 cggagcggca agctcacccg tctcttcaga atagatcgca gcgtccgtac tcggccaagg 2415961 acagccgata ctgcccggct tgttttttcc ccagataaag ttggcgtgcg tcactgggga 2416021 tgcctcagac aaaccatagc cttccacaag ctttccacca gtcacctttt caaatttctg 2416081 ctttacctcc acggggagcg cggctgatcc gctaagacag cttttaatgg atgacagatc 2416141 ataatgctgc aattcagggt gatgcaaaag gccaatgtaa attgtcggtg cgccaggaaa 2416201 gagcgtcggt ttgtgtttgt cgatgatttt aagtgtttcg agcggatcaa acttaggaag 2416261 aagaatcatt tcgaagccta gtttaatcga atagttcatg actgccgtca gtccgtagac 2416321 atgaaaaaat ggaacgatgc ccagcacttt ttcagcgcct tctttcacgt catacatcca 2416381 agcggcgcac atttcagtat ttgccaaaat attttggtgc gtgagcatga ccccttttgg 2416441 agctccggtt gttcctccgg tatactggag gacagcgata tcatgctcag gatcgatctt 2416501 cgggattgtc aggagttcag ttttttcctg cttcatacag gaagcgaacg tgtgaatgtt 2416561 agctgttttg tcaaagtcga tatgcacttt ttgtttttgc gtcagcgggt aaagaatatt 2416621 tttcggaaaa ggcaaatagt cttttacact ggttatcaaa atctggtcga ctattgataa 2416681 cgttttcatt tttattgcct tcgggaaaag caaatctaag gtgatgatta cacttacctg 2416741 agcatctcta agctggtatt caagctcatg ctcggtataa agcggattcg tctgcaccac 2416801 gatgccaccg gcaaacaaga cgccataata agaaatcact gtttgcgggc aattgggcag 2416861 cataacagcc actctgtctc ctttttgcag gccattgcac tgcaaaaaag ctgcaagttt 2416921 aagagcatcc gtcagaatgt catgaaaggt gagttttttt ccataaaacg atattgcggt 2416981 tttatcaggg aatcgtgcgg cggagtctgt caggatggat tgcagggttt tattcggcaa 2417041 cggaagctca tgcgggatat cgttgggata ctcggcaagc cacggctttt gagactgcat 2417101 aaaacctccc ctttcgattt tagagatcca ccttatcatt atagcagatg gacggcaaaa 2417161 aaaagaaaaa gaaaggtaaa tctttctttt tctcataata tgaacagata tataagacca 2417221 attaacaaaa agattcccgc tgcggcgagc agtattttcg caagcttttc catctattct 2417281 ccgtcccctt atattccggc tgccaccaca aaagaaagcc cgacagaaat gacaaatgaa 2417341 ataaagccga cagcccggtt atcattttcg atttcctgat caattttaaa ccgcggagtc 2417401 aaaaactcaa aaataaagta gctgatcaga agcataacaa acccgtaaac gccccagccg 2417461 atcatttgca gcagcgaatt atgctgggag atggaatgct gaaatacgtt tgcgattccc 2417521 aaaatttttc cgccggtcgc cattgccacc gcaagatttc ctttttgaat ctcttcccag 2417581 tttttataag ccgtcaccag ctcaaacaca gtcaaaaaga ggacgaggca gagaaccgcg 2417641 acactgtaat atgccgcgat ttccacaagc tcgttttccc aaaaatcact catggccata 2417701 ctccctttta ttttagttca acaaccgtaa cgcctgatcc tccctcacct gcttcaccga 2417761 aacgggaact tttgacgctg cggtggtttt tcagaagatc ctgtacgcct tttcttaaag 2417821 cgccggttcc ttttccgtgg atgattgaca ctcttggata tccggctaac accgcatcat 2417881 ccaagtattt ttcaacccgg ctgagggcat tttcatagcg ttcgccgcga agatcaagtt 2417941 caagcgatac gtgatagtcc tttcctttga ccgctgtaat cattttttct ttttttggct 2418001 ccggagctga tttgataaac tccagatctt tttcttttac tttcatcttt aaaataccga 2418061 tttgaacgtt ccattcattg ccgcctgttt tttcgagcaa tgttcctttt tgcccgaaag 2418121 tgaggacttt cacctcgtcg ccaggcttaa agtcgcgttt ttgcgttttc ggcttttccg 2418181 gtttcttgga cttttcaaaa gcaggcatag cgccttctaa ccgtttcttc gcgttaatca 2418241 gctcgtgatc cttgaaggat ttgtgttctt cttttatggt gcgcaattca tgaataatgt 2418301 cctcggcttc tttcattgcc gcttttactt tttcagcagc ctgctgttct gcctcttcaa 2418361 gcattttgtc ttttttgctg ttaagctcga tgatttgctg ctgcagctct ttatgcagtt 2418421 tttccgcttc ttttctgatt gattctgtct cagaaagctc ttcttccgca cgttttttgc 2418481 tttgttccag cgacgcaatc atcgtatcga cttcgttatg ctcggccgtc atttctgact 2418541 tcgcctgccc gatgatatgg tccgggagcc cgaggcgttt tgaaatttcg aaagcattgc 2418601 ttcgacccgg cacaccaatt aaaagtttat aggtcggtga cagcgtttcg atgtcaaatt 2418661 caacgctggc attcatgacg ccttctctgt tatagccgta cgccttcaat tccggataat 2418721 gcgtcgtagc taacactcgt gcattggtgc gatgcacgtc atccaagatg ctcatggcga 2418781 gggccgcccc ctcctgcgga tctgtccctg caccaagttc atcgaaaagc acaaggctgt 2418841 tttcattgac ctgttctaaa atgccgacaa tattcaccat atgggatgag aacgtactta 2418901 aactttgctc aatcgactgt tcatcaccga tatcagcgaa tacgtgctca aatactgccg 2418961 cttctgaccc ttcatctgcc gggatatgaa gacctgactg cgccattaag gttagcaggc 2419021 ctaacgtttt aagggtgact gttttccccc cggtgtttgg ccctgtgatg acaatggttg 2419081 aaaaatcgcg gccaagctcg atgtcattgg caacaacctg atcaggcgga agcaatggat 2419141 ggcgggcttt tttcaaacgg ataaagccgg tgtcgttcat aatcggtttt gtcgctttaa 2419201 ccgcttttgc atatctagct tttgcaaaaa taaagtcaag cgtctgcagc acttgcaaat 2419261 ctagaaatag ctcctctgta tactctgccg ttttctctgt cagcacacgc aaaatccgtt 2419321 caatttcttg cttttctttc actttcgcct gctgaaggga attgttcata tctacaatcg 2419381 cctgcggttc aatgaatagt gtcgcaccag aggatgaggt gtcgtgcaca attcctccat 2419441 agctggatct gtactcctgt ttgaccggga tcacaaagcg gtcattccga atcgtaacaa 2419501 tcgtatcaga cagcattttc gatgcggaag aggaacgcag catcgactct aaccggtctc 2419561 tgactcttga ttcgagtgtt ctgagctgtg tgcggattcc tcttaatgtt tccgatgcat 2419621 gatcaagcac ttctccgtga tcatcaatgc aggaattaat gtcccgctct aaatcggaca 2419681 gcgtgataag ctgttcagca tgctgatgga tcagcggaat gtcgacaccg tcttcagcca 2419741 tttgcgtgat aaaatgtttc atttgtttaa ctgcataaag caggcctgag atttcagtga 2419801 attcagaagg actgagaacg ctgccgattt ccgcccgtct taacgctcct ctgatatcta 2419861 caaggccgcc aaatggcgct tggcctctca gccggataat gtcagaagct tcgtctactt 2419921 catccagctg ttttttgatt tcgtctatag aagcagaagg cttaagctcg agaagcattt 2419981 cttttccgag cgatgaagcg gcatgcccaa taacctgttc tttcacttta tgaaattcaa 2420041 gagctgataa tactttttgc tgcacgattg tgtgagcctc cttacttaat cgttgcgctt 2420101 cagaaatgcc tctacgtctt taagcgaccg ggcattcaga acgtttttcg tttccgtcca 2420161 tcctttgcgc gcggcagtaa cgccagtttt catatcgtct aacatctcaa tattatgggc 2420221 atcagtatta atcaccaatg taaccccttg ttcgtttgct ttcattaaat gctctgtgcg 2420281 cagatcaagg cgcgcagggt tggcattgag ttcaagcgcc gtatttgttt tcctcgcaag 2420341 ctcaatcagc tgatcaatat cgatttcgta accggcccgt ctgccgataa ggcgcccggt 2420401 cgggtgtgcg ataatgtcaa catgcttgtt tgtcagtgcc gtctcaagcc gtttcataat 2420461 cacgtgttcc ggctgattaa aactggaatg aatcgatgca ataacgatat ccatttccgc 2420521 aagcacatcg tcatcataat cgagcgtacc gtcaggcagg atatccatct caacgccttt 2420581 caaaatacgg aagttttcaa actctgcatt cagcgcgtca atttcttttg cctgctgctt 2420641 aagtctttct gcagtaagcc cgttggcgac ctttaaatat tgtgagtgat cggtgatcgc 2420701 catgtattga tagccttttt tgatgcaggc ttcagccatc tctctgatcg aaaatgcgcc 2420761 atcgctccac gttgagtgca tgtggagatc acctttgatt tgcccgagct ctatcagttc 2420821 aatgctgtcg ctgtaggttt ccacttcctg tccgctttca cgaatttccg gcggaatcag 2420881 cggcaggccg aagtgcgcat aaaattcacg ttcactcgga aatgttttga tctctccggt 2420941 ttcaactgtc tcaacgccgt attcactgat ccgctcgccg cgttctttgg cgatttggcg 2421001 catcttaata ttgtgatcct ttgatcccgt aaaatgatgg agtgttgtcg gaaactgctc 2421061 ttccgtcaca agacggaaat cgacgcttgt ttcatattca aaggaaagga tgacggacac 2421121 cttcgtatct ccgcttgcga tcacgctttt gatgtttggc agctcaagaa gctgctctct 2421181 tacttcagcc ggatgatctg tagcaatgat ataatccaga tccttcaccg tttcccgcgc 2421241 tctgcggaga cttccggcac gagaaaattt gatgatatgc gtaaattgag aaagatgctc 2421301 ctcaatttcc cgcgcgatcc ggagggcgta gccgatcggg aaccgttcag gctgttttcc 2421361 ggcttccccg agcgcctgta atattttttc ttccgatttt ttgccgaagc ccgcaagacc 2421421 ctggaccttt tgctgctcac aggcttcctt cagagattct gcatcgtgta cgccgagctc 2421481 tttatacagc tttgcgattt ttttgccgcc gagccccggc agcttcaata aaggcacgag 2421541 tccttccggc acttctttct gaagcgattc gagcgtgctt gactttcctt catctatata 2421601 ctctttaatg acgctgtacg ttccttttcc aatgccggac agcgacatca tatcgtccat 2421661 ttctgataag cttcggtcgt cctgttccag agctgccgcc gcttttcgga aggcggatac 2421721 tttaaacggg ttgtcccctt tgagttccat atagactgca atggtttcaa gcagccggat 2421781 aatatctttt ttatgcatat cataaccccc agacgttcac atatgtttcc atcatacttg 2421841 aaaaaaactt ctccggacaa gagaagtttt tttatgcccc gtactgtgtc cacagctctt 2421901 gtaaaagccc tgacaagtac ggtgtatggt taatgatcac atttgcgaga gacgattgcc 2421961 ccatcatttg ctgcaacgcg tctaccggca gaacggatgc gacatacagc agcacaaatg 2422021 taaataaata gacttctaga aaaccgagaa cggctcccag catctggttg atttgtttaa 2422081 tcaccggaat gccggctaca atactcagga acgagccgat gattctcagt aagattttag 2422141 caatgataaa taaaacgata aacgcaatcg cattatagta cgctgcttcc aaattccccg 2422201 taaaaaaaga aagagccggc tgtcccgctg aaaaatcggg tgcgggaatc caatgtaaat 2422261 gcggtgccac gtttttatag aataaagccg caaaggcaat tgataaaata aagctcgtca 2422321 agcggataaa ctgcaggata aaaccgcgtt ttaaccccag taaagtcccc atcaggagca 2422381 agattaagat gatgatatct agcatagttg ttcaatcctt ttctttaagc tgacgctcca 2422441 gtttttcaca tttctcttgt aatttgacat aatcgtgcac cacatttacc gctgtcagca 2422501 ctgcaagttt atttatatca aggtatggat ttttttcatt gatttctctc attttatcat 2422561 caacaattcc ggcgacatac ctcatatggg ctctgctttc ttcaccgaca atcgtgaagt 2422621 gctggccgta aatgtcaacg gttgtttttg tttttttgcc gtcagacaac gtttctcctc 2422681 cattccgcga gaatcctagt tcttatcata acacgtttat taaatgaatg gaaagacgag 2422741 cctcccgctg ttatgataca ctggtatata cagcgaaaag tgtaaaaaaa ggagattatt 2422801 acgtgtccca ttcagtgata aaagtatcgt tgtctgctat tgaccaaatg aaaatgacgt 2422861 acagcggttc acttacagcc tctgttccgc agggagccgt ttttcaggca aaaccgcccg 2422921 gctgtaccat tacagcatat caatcaggta aggtcttgtt tcaaggaaaa aacgctgcgg 2422981 cagaatccgc gcgctgggga acagcagagc ctcaggaaaa gaagaaaacg gccaaaaagc 2423041 cggctgatcc ccgctatgcc cctccggcag atatcgccgg aatgtctgtt atcggttctg 2423101 acgaagtcgg aaccggagat tactttggcc caatgacggt tgtatgcgcg tacgtcgaca 2423161 aaaccatgct tcctttaatg aaggaactcg gtgttaagga ttctaaagat ttaaaagatc 2423221 cgcaaatcat cgagattgcc cgaaacctga ttaaaaccat tccgtacagc ctgctggtgt 2423281 taaagaatga aaagtataac agcatgcagg aaaaaggcat gagccaaggg aaaatgaaag 2423341 ctttgctgca caatcaggcg atcacacatt tattaagaaa attggatgga gtaaagcctg 2423401 aagccatttt gattgaccaa ttcgctgagc caggcgtcta cttcaatcat ttaaagggca 2423461 gagacattgt gaaggagcgg acctatttta gcacaaaagc tgaaggtatt cacctggctg 2423521 tcgccgctgc ttcaatcatt gcaagatatt catttttaat ggaaatggat aaactatcac 2423581 gcgcggcagg aatgacgctt ccaaaagggg ccggtccgca cgtcgatgaa gcggccgcca 2423641 agctgatcct caaaaaaggg gcatctgcac tcagaacctt tacaaaactc catttcgcca 2423701 atacgcaaaa agcgcagcgc cttgctgata aaaaacgttc atagaaaaaa gcttgcagat 2423761 ttctctgcaa gcttttttat cagcctctta aaacagcttg atatgtgtct tctaacgctt 2423821 tcagcacttt gctgtgcgcc tttgtcactt cttcttcagt cagtgtttgt tcaggattga 2423881 catactggag tgagaaagcg actgacttct tgccttcctc catatgctct ccttcgtata 2423941 cgtcaaatac ggttacctct ttcagaagct tgcccccggc ctctttaatg acgctctcga 2424001 gctgtccgct tgtgacggtt ttatctgtta caagagcgat atcacgtgtc acagacggat 2424061 attttggaat cgccgtgtaa acaagcggtg ctgtttctgc tgcgagcaac gcatgaagat 2424121 cgagctcaaa tacgtatgtt tcctttatat ccagttcttt ttccaatgaa ggatggactt 2424181 ggccgatgaa gccgatcaga gaaccattca ataaaatgtt cgctgttctg cccggatgca 2424241 gctgtttgcg ttcagactgt acaaattcaa tgctgtctag gacgttgagt ttgtctaaca 2424301 gcccttccac aattcctttg acaacaaaga aatcaactgg tttcttttca ccctgccata 2424361 gctgcttgcg ccataatccg gtaacagctc ctgctacgcg ttctgtttca acaggttttg 2424421 tgtcctcttc cttcgttagg aaaacggagc caacttcgta cagtgcaact gagtcagtct 2424481 gcctcgcaag attgtaagaa acagaatcaa gcagatttgg aacaagactg tgtctgagaa 2424541 tgcttctttc ttcactcatt ggaagcgcaa gcacagtatt cagtgatttt tcaatcgcaa 2424601 acgctgtcgc tttcttctcg tttgtcagtg agtaagtgat ggcttgtgat aagcctgcgc 2424661 cttcaaggaa gcgtctgact ttacggcgtt ttgcctgata tggcgttaat ccgcctgtag 2424721 ttcccgctgt ctcaggaagc gtagacggaa tgttatcgta gccgtacagt cttgccgctt 2424781 cttcgattaa atcctcttct attgtaatgt caccgcgccg tgatgggaca gtcacaacga 2424841 gaagatcatc cgcttcaccg accgtaaaac cgagacgttt ataaatgctg atcagttctt 2424901 ctttactgat cgtcaggcct agaacgctgc tcactttgtc agcagatacg tgaatgttat 2424961 ttgcttcgat tgtcaggtga tcttcctcaa ccgttccagc aagcacctca ccgccggcat 2425021 acagatggat cagctgcgca gcccgttctg ctgcaagacg tacgcgtgcc ggatcaattc 2425081 ctttttcaaa tcttacgctt gattcacttc tcaaaccaag gtctttggaa gccttgcgaa 2425141 ccttctgccc gttgaaatac gcagcctcaa gcaaaatggt tttcgtatct tcctgaacct 2425201 ctgactctgc tcctcccatg acaccggcaa cggcctgcgc tttcgttccg tttgtaatga 2425261 caaggtgatc ggcagacagc ttacgttctt gatcatcaag tgttacgatc atttcattct 2425321 cagctgcttt tcttactacg acttccttag agccaaatct gtcataatca aacgcatgaa 2425381 gcggctgtcc gtattccaac aggacaaaat ttgtgatgtc aacgacgttg ttgtgcggac 2425441 gaatgcctgc attcatcagc tttgtctgca tccaaagcgg tgacggagca atcgtgacat 2425501 ttttaatgat ttttgcagtg tacagcgggt tcgcttcttg atcttcaatt ttgactgaaa 2425561 tgtaatcaga cgcttgttct gaagcagccg ggtaatccgt ttgcggaagc tttacctcag 2425621 tgtctaaaat cgccgcaacc tcgtaagcaa caccaagcat gttcatggca tccgcgcggt 2425681 ttggcgttaa acccagctca agaatcgcat cgtcaagctg taaagccgct aaggcatcgc 2425741 ttcctgtttc agcgtcattc gggaatacga aaatgccttc tgcatactcc ttcgccacaa 2425801 gtttgctttc gataccaagc tcctgtaagg aacagatcat gccgtttgat tcttcaccgc 2425861 gaagcttggc ttttttgatt ttgaaattgc ccggcagcac cgctccgact gttgcaactg 2425921 cgactttttg tcccttatcc acattcggcg cgccgcaaat gatttgtaca ggggcttcag 2425981 ctccgatatc cacaaggcac ttattcagct tatcagcatt cgggtgctgc tcgcgctcca 2426041 gcacatggcc gatgacaacg cctttgatgc cttctccttt gtattcaatt ccttcaacct 2426101 caataccggc tcttgtaatt ttttcagcaa gaacagccgg gtccatgcct tttaaatcaa 2426161 cataatcctc taaccattta taagaaacaa acatccttgc atcctcctct tacgcctgtt 2426221 taaactgcga aataaatctg acatcgtttg tatagaagtg gcggatatca tcaatgccat 2426281 atttcagcat cgcgatgcgc tcaacaccca ttccgaatgc gaagccctga tattccttcg 2426341 gatcaaagcc agccatttta agcacgttcg ggtgaaccat tccggcaccg aggatttcaa 2426401 tccagcctgt tcctttacat actgagcagc cgttcccacc gcatttaaag catgtcacat 2426461 ccacttctac tgaaggctca gtaaacggga agaagcttgg gcggagtctg atttcacggt 2426521 cttgcccgaa catttttttc gcaacaagtt caagcgttcc ttttaaatca ctcatgctga 2426581 tgtttttgtc aacgacaagc ccttcaattt gcataaattg gtgagagtgc gtcgcatcat 2426641 cgttatcacg gcgatatact ttacccgggc aaatgatttt aacgggacct ttgccttcat 2426701 gcttttccat cgtacgtgtt tggacaggag aagtttgcgt tctcatcaaa gtttcctctg 2426761 tgatgtaaaa gctgtcctgc atatcgcgcg ctgggtgttc tttcggaaga ttgagcgatt 2426821 cgaagttgta gtaatccgtt tcaacctctg gcccttcctc gactgtgtag cccataccga 2426881 taaataaatc ttcaatttct tcaatgacaa cagtgagcgg atggcggccg ccgactgcaa 2426941 cagggttccc cggcagcgtg acgtcaattg tctgtcctgc aagcttctgt ttcatttcct 2427001 cttcttcaag cttctcgttt ttgtcagcaa tcgcattggc aatacgctcc cttacttcgt 2427061 tcgcgagcgc ccccattttt ggacgttcct cagcagaaag cttgcccatt ccgcgcagca 2427121 cttctgtaat cggccctttt tttccgagat attgcacccg aatatcattg acaaccttca 2427181 atgagcttgc cgcttctact tgttctaaag cttcttgttc cagctgtttt agcttttctt 2427241 ccattttgca tcctcctttt atgtaaacaa accgtcatat gtctttggaa aataaaaaaa 2427301 acccgtccct tgtacaaggg acgagttgtg gccgcggtac cacccttatt tcagacagac 2427361 tgatgctgtc gtcagcttca ttgacataac ggaatcagat tccggttcac ctttacgcgc 2427421 agtgtacgcg gtcccggcga caactcaaga ggtgaagcca atttccggct gcgttaaaaa 2427481 tgctctcagt cagcggcatt ttctccctgg aaagcagttg atcagaaatt gaggtcctct 2427541 gtcacggttt ttgaaatatt atgttctatt atagagaaat ccaacgcttg gcgcaacact 2427601 atcctcgcaa gtgatacacg aggatggcag ccgcaaccgc aacgtttagt gattcagcct 2427661 gtccgtaaag cggcacgtac aggttcaaat ccgttttttc cagcaatgca gcatctaccc 2427721 ctgcaccttc atttcctaca atgagcgcaa aggattcaga ctgaggaatc tcctggtaag 2427781 gcgctccgtt ttgcagcgcc gtgccgtata cttttacgcc ctctgccttc aattcgtcca 2427841 catatgaagg caggtttctt ctcacaacag gaatatggaa gtgagatcct tgagcagatc 2427901 gcagtgtttt tccgttaaag gcgtccgccg tgccgtcacc gagtacaacc gcatccaaac 2427961 cggccgcatc agccgttcga atcattgtgc caaggtttcc cggatcttga acagcgtcaa 2428021 tcagcagcac cttgcgtgcc gttgccagct tttcttcagg catatggcac acagcggcaa 2428081 tctgctgcgg cgtttcggtt tcagtcacag ctgaaaacgc atcttcactc agcatatagc 2428141 actggatacc agtctcaaga tctgaaggaa tcctcgtttc atcctttaca aggatttctt 2428201 tcacaatgcc cgggcttttc aacgcctctt caacgaggtg ttctccctct atcagaaatg 2428261 tatttgtttt tgttcgttct ttttttgtgt gaagcttttt ccaatccttc actttttggt 2428321 tttttgccga ttctatttgt ttcactgtct atgtggcgct ccttttttta acatgatgtt 2428381 attatatcgc aagaacagca cataataaac caggtgcagg gttagaatat acgtattaca 2428441 ttttagaaaa aggagcgttt tacatggatc ttaatttacg tcatgccgtc attgccaatg 2428501 tcaccggcaa taatcaggag cagcttgagc atacaatcgt agatgcgatt caaagcggtg 2428561 aagaaaaaat gcttccaggg ctcggcgttt tattcgaagt catttggcag cacgcatccg 2428621 aaagtgagaa aaacgaaatg ctgaaaacgc ttgaaggcgg attaaaaccc gccgaataag 2428681 acatgaaacc gggtgacagc gcccggtttt tttcttatat aataaaaaca tgatgagggg 2428741 gaacgccatg tttttacagc cgttattagc gaaaaaaatt attgctgaag ttaaaaaaat 2428801 gtacgaacgt gaagtcatta ttgtaaacac ggacggtctt attatggcag gcacaaacga 2428861 tgagcgtgtc ggacaatttc atgagggagc gcttatctgc gcaaaagaaa gacgcagcgt 2428921 gattattaca aaagaagatg aaacaaggtt aaaaggagtg aaagcaggca taaacctccc 2428981 tgtatttttt gaccatgatg tgattgccgt cttcgggctg acaggtgagc ctgcagagat 2429041 tcagccattc ggagaactgc ttcgaaaaat gacagaactg ttcattaagg aatcgcggca 2429101 cttagagcaa tcccagtggc gtgagagaat gctggagtcc tttatgatcg attggctgca 2429161 attaaaggag tggtctccca gttttcttga gaaagctcag cttcttggtg ttgacctttc 2429221 ttcccggcgc caaatgattc ttattcaggg gtatgagtgg tcacctcatg atattgaaca 2429281 aatggcacgc agctggaaat cctcgtaccc tgcggatttg ttcatcaggt ggggaaatga 2429341 acggattttg attaatcatg aagtgccgca gcatgaacaa agggatcggc ttttgcggaa 2429401 aatccttcac atttgttcgt ttgccaatac cgcaagcagc caatatacag cagctggcgc 2429461 cggaagggct gtcgcaagct ccagcctgac agattcatac gagcaagcgg aaaaagcgct 2429521 ggctgtcagc cttaagcgaa aaacgcccat atttgaagag gatctgaagc ttgatatgtg 2429581 tctgacggag atcagcccgg gaacccgaaa cgaatttccg caaagagtat taggaaaggc 2429641 gctagagcat caggaactta tgaatacgat acggactttc tttcatcacg atttgtcttt 2429701 gaaacaaacc gctgaagaca tgcatataca catcaataca ttgcgttatc gtctggctaa 2429761 ggctgaacag ctgacgggat tacgttttga ccgtaccgag gacgtcgtca cgatgtacgt 2429821 cgcactctat tttttagatc aagatacaaa atagagagag tttcagtttc attttttgta 2429881 tgtttctcca tggaaggctt tgcttttttt cttttacaat agattgaaag cgttttttga 2429941 cagggggatg ggtgaaatga tcaccaagga tgtaaaggag cagctgattc aggtctccgg 2430001 accagaaaac tttgatgact cgaatgccgg ccgtctcgtc tattcatatg atgcgacgcc 2430061 tcagtatcag tctatgcctg atgccgtgat tgctccgagg aatactgatg aaatatcacg 2430121 cattttaaca atttgcagcg aacatcgagt gccgatcgtt ccaagaggat cagggacaaa 2430181 cctgtgcggc ggcacgtgcc cgactgaagg cggacttgtg cttctcttta agcacatgaa 2430241 ccagattctt gaaattgatg aagaaaattt aactgccaca gttcagccgg gcgtcattac 2430301 gttggatatg atccgggcag ttgaaagcaa aggtttattt tatccgcctg acccgagttc 2430361 tatgaaaata tcaactatcg ggggcaacat caatgaaaat tccggcgggc tacgcggatt 2430421 aaaatacggt gtcacccgcg actatgttat tggactggag gttgttctcg caaatggtga 2430481 catcatccgc accggcggaa aactcgcaaa ggatgtggcc ggatacgatc tcacacgtct 2430541 ttttgtcggc tcagaaggaa cactcggcat tgtgacagag gcaatcgtca aactcgttcc 2430601 aaagccggaa acaaagaaga cgctgcttgc cctttatgaa aacatcgatg ccgctgctca 2430661 aacggtatcg gacattattg ccgcaaaaat tatacccgct acgcttgaat ttctcgatca 2430721 gcctacacta ttggtgattg aggattatgc caaaatcgga cttccgacaa gcgcaaaagc 2430781 agttctgtta attgaacaag acgggccatt tgaaactgtt gaacgggata tggaaaagat 2430841 tgaggcgatc tgcaaaaaag gcgacgccgt atccgttcag accgcacaaa cagaggagga 2430901 agcgtttgcc ctgactgaag cccggcgttc tgcactttct gccctagccc gcctcaaacc 2430961 gacgacgatt ttagaggatg cgaccgttcc tcgctcagaa atcgccaata tggttaaagc 2431021 gattaatgat attgctgcta aatatgatat ttccatctgc acctttggtc atgcgggaga 2431081 cgggaacctt cacccgacat gcacgacaga cataagaaat aaggatgaaa tggaacgtgt 2431141 cgaacaggct tttgccgaga tttttgagaa agcgattgaa cttggcggga cgataaccgg 2431201 agagcacgga gtcggggaaa tgaaagcgcc ttacttggaa atgaagctga aaaaagaagg 2431261 cattgatgcg atgaaagcgt tgaaagcggc atttgacccc cggaacatat taaatcccgg 2431321 caaaatgttt gcgaaagatg ccagaaaacg tgtggtggcg gaaagatgac aacagaaaaa 2431381 gaaatgaaac agatccaaaa tgaatttaaa gagcgtatgg atgaaggaga gttattaaat 2431441 tgtatgcgct gcggcttctg tcttccttcc tgtccgacct atatcgaatc gggatttcag 2431501 gaaacacact ctccgcgtgg gcgcatcgcc ttaatgaaag ccgtagccga cggtatgatt 2431561 gaaccggatg aagatgtcga acggtcgctg tcactttgcc tcggctgccg cgcctgtgag 2431621 cctgtatgcc cgtctggcgt gaaatacggg cagctgcttg aggaagccag agatattatc 2431681 caccaaaata aaaaacactc tcttggtgaa cgtgtcatgc gaaagacggc ttttcacgag 2431741 ctgtttccgc atcaaaaccg catgcgctca gctgtaagcc ttatcggttt gtatcagcgt 2431801 tcaggactgc aaaccgctgt gcgaaaatca ggcatgcttc gggtcctgcc tgagcatttg 2431861 cggacgatgg aagctgttct tcctgatgtt ccaaaaagca aagacatgaa acatcggccg 2431921 cgtttcctgc cttccattgg ccccatgaaa aaacgggtcg cctttttttc gggctgctta 2431981 atggatacaa tgtttttacc gaccaataac gccacattga agcttttaca gctggcaggc 2432041 tgcgacattg tcattccgcc tgaacaggct tgctgcgggg cgcttcatgg acacagcggt 2432101 gaaaaaaaca cagggaaaga gctcgcgaaa caaaatatcg ctgctttcga agcattagac 2432161 gtggatgcag tcattacaaa cgcaggagga tgcggagcct ttctcactga atatgatcat 2432221 ttgctgaagg atgaccctga gtggtcggaa cgggctgccg cttttgttca aaagctgaag 2432281 gatttttctt ctgttttggt tgaactcgat ttccatcaaa tggatctagc actcgagacg 2432341 cctcaggtcg ttacctacca agattcatgt catctaagaa atgtgatgca tacgtcactt 2432401 gagccccgcc agcttcttaa aagcatcaaa ggggcggaat tcaaagaaat ggagaaagca 2432461 gacagctgct gcgggtcagc gggaatttac aacatcgtcg aagttgaaat gtctatgaaa 2432521 atactggaca gcaaaatggc tgccgtcaaa gcaaccgaag cgatcctcat tgtaacagca 2432581 aatcctggct gcctgctgca gatgaagctc ggcattgaac gcgaaggact aagcggtaaa 2432641 gtcagagccg ttcacctggc tgatttgcta ttagaagcag ccgggcacaa aacatcatga 2432701 gaaagcccaa aacagacatt gttttgggct tttgtgcgtt attccatcgg actgcaaatt 2432761 tcgatataat gtccatccgg atcagcgata taggcgaccg tctgccccca tggtttcact 2432821 ttcggctccc cgataatcga tacgccttgt tctctcatcc ttttgatgac cgcttctaca 2432881 ttttcagtaa caaacccgat ttcaaatgtg tttgaagcag atgtatccgg aatgtccagc 2432941 gccgtgatgt ctctggcgct ttcccgggta ttaagcgcca atatcgtaga ccctgtatca 2433001 aattcgacat acgtgccgtg ttcagcacga atcggcagtc ctaaaatatc ccggtaaaaa 2433061 atgaatagcc cgcttgctgt ccgatacgta tagaataaga tatttcattg atagattcat 2433121 tgccaacccc tctcagcatt ttcaatagtc cttctagccc ggtatagatg cttccatcct 2433181 taagctcgga tctttccaca tctgcgccca ttttttcaca gccgccacga taatgatgaa 2433241 gcctaacacc agcatgatga tagataatac gccattcaat acactatatc ctgctgcttc 2433301 aggattgaga tacacattgc gcaccatcca atagcccgca taattgacag tgacatataa 2433361 ataggcaagc gggataaggc aagtcagaat gtaccggcgt ttatcggcga ttttcagcac 2433421 gatcgtcgct ccgataatca gccccactga agccatcagc tgattagaaa cgccgaagag 2433481 cgcccaaatg gaaccgatat ctcctgaata cagcaagtac ccccacatca aacaggcaag 2433541 cgcgctggca aatacagagc ccggaatcca gtctgttttc ttcagcggct tatacacctc 2433601 cccgaagaag tcctggatca aataacgggc gacacgtgtg ccggcgtcaa tcgctgttaa 2433661 aataaagacc gcttcaaaca taatgacaaa ttggaaaaag tatgaggcca aatggctgaa 2433721 aaacggcatt ccggtaaaaa tataagtcat ccctaccgca agcgtgacgg ctccccctgt 2433781 tcttccttct aagtccaaac cgatttcccc gctcaattca ggcaaatgta cgacattcat 2433841 gccaagcgta cggaaaacct caggcgtgct gttaatcgca aagtaatcag caggctgtaa 2433901 agcggtcgct gcaatcagcg ccatgatacc gacaagacac tcaacaagca ttgcgccaaa 2433961 cgcaaccggc ttcatatcac tccatttatt cagcattttc ggtgtcgttc ctgagccgac 2434021 aaaggcatgg aacccagaga tcgccccgca ggcgatggtt attgagatga acggccagac 2434081 aggtcctgcc agcaccggcc ctccgccttt tacgaattct gtaaacgcag ggaacggaat 2434141 ggacggattg acgacaaaca caccaacaat caaagcgata aaaacaccga ttttcataaa 2434201 gctgcttaaa taatcacgcg gagccagaag cagccaaacg ggaagcgcag ccgcaaaaaa 2434261 cgcataaaca ggaagcgcga ttgcaagcgt tttcgtatct agcgttaaaa agtcaccgag 2434321 cgcggtagtc tgtacccatg gaccgataaa gactcctgcc attaaaaaga gaaagccgac 2434381 cgttgaagcg agctttaaat ttcccgtttt cttataaaat aagcccacac ccatcgcaat 2434441 cggaatcgta atccccaccg caaatgttcc ccatggatta cgttcaagcg catgcaagac 2434501 aaccatcgac aggcccgcca ttgtgatcgt gatgataaac agcatggaca gtcctgtaca 2434561 aaatcctgca acagggccaa gctcatcctt cgccacttcc gacagcgatt ttccgttttt 2434621 gcgcatcgat gcaaacaaca ccacaatatc atggacggct cccccaatta ccgccccgat 2434681 taacagccac aataatcccg gcaaatagcc aaactgcgcc gccagaattg gtccgaccag 2434741 cggcccggcc gctgcgatcg cggcaaagtg gtggccgaac gaaacccatt tatttgtagg 2434801 cacatagtct ttcccatcct caagcgcatg agcaggtgtt ggcttgtcat cattcacttt 2434861 gagaaccttc accatcataa atgttccgta taaacgatag gcaatagcca aaatacacat 2434921 tgatgctatc acaattgtaa ccgcattcat tttctcccat ccccttttct gtttttcata 2434981 aatatatcat aatttcatgg tgaaaagcgg tcattttttc ctatacaaaa agccggctgg 2435041 aatgggccgg ctcgtggcag ttgaaagaca agccggagag aaatctccgg ctttgctatt 2435101 cttatgactg ttttttcagg cggatcacat tccaggaaag cggcgtgaaa tgagcagtta 2435161 agccgttttc gctgacagac gatgatccgt tggaatgcgg aacgacattt tttctgttat 2435221 gctggtttgt tgctttgata tcctgatgct caagtacgat gtgctctgcg atttggtagg 2435281 attcaaagcc tctgagcgaa atctccgtct ccatctgatc ctcagccttg tttaccgcaa 2435341 aaatagtgag tgtttcttcc tcttcagagt acacaacagc agcatcaaca tatggcacat 2435401 cagtgaaatc agaacaatcg tacttaggag aagaaataag cggtttcagt gactcgcccc 2435461 ttccgtaaac agaagcatgc atgtatggat agaaaatcgg ctgtctccat gcttctccgc 2435521 ctttttccgt catgatcggc gcgatgacat taacaagctg tgcaagacac gcaattttca 2435581 cacggtctgc gtgctgcagc atcgtaatga gcagagagcc gactaataag gcatcttcaa 2435641 aattgtaaat atcctctaaa atcggacgcg cagtgatcca cggctcgact tttttatcag 2435701 cctcatttga gtggtaccag acgttccatt catccagaga gagattgata gttttcttgc 2435761 tgcgtgtttt tgcttttaca tagtcacagg tcgcagcgac tgatttgata aaatgatcca 2435821 aatccataga acgtgccaag tagtttggca gattgttatc ccggtttccg tagtaagtgt 2435881 gaagagagat atagtcgaca tgctcatacg tatgctcaag caccttcgct tcccaatcga 2435941 taaaggtcgg cataccgctg tttgagctgc cgcaggcaac gagttcaatt gatgggtcaa 2436001 cccacttcat gacctttgct gtctctgcgg caagccgtcc gtattcatca gctgttttgt 2436061 ggccgatctg ccatggtcca tccatttcgt ttcctaagca ccatgttttg atgccatacg 2436121 gctgttcata gccatgcgat cttcttaaat cactccagta agagcctttc ggatggttgc 2436181 aatattcaac gagattacgg gcggcatcta tgcctcttgt gccaaggttg acggccatat 2436241 tgacctcagt gttcaccttt tttgcccaag ataaaaattc atttgttccc acttcattgg 2436301 tttctgtcgt ttgccatgcc aagtcaagcc gtctcgggcg gttttcgact ggtccgacac 2436361 cgtcctccca gttgtatccg gataaaaagt ttccgcccgg atagcggatg atgggaacct 2436421 gtaattcttt gatcagcgac tggacatctt ttctaaatcc atcttcatcc gcttcagggt 2436481 gatcaggctc gtatatgcct tcatataccg cacgacccat atgttcgata aacgagccat 2436541 aaatccgttt atctacttca ccgattttat attctttgtc tacaatcatt cgcgcttttt 2436601 tcatcacacg tttcctcctt cattaacctt tgactccccc taccgtcagg ccggagataa 2436661 agtacttttg gaaaaacaag aaaatgataa tcaccggcaa aatcgcaaat actgagccgg 2436721 atataagcat gtcgtaatta tttccataag ggctcagcaa gctggacagc cctattggaa 2436781 gcgtaaacat ttctttcgac cgaagcacaa tcagcggcca caagaagttg ttccagctgt 2436841 ttaaggactg aaggataatc atcgcaccga aagccggttt catcagcggt gccataatcc 2436901 tgaaaaagat gccgaattcc gtacagccgt ccatccttgc agagtccagc agatctcttg 2436961 gaaggccaag agcatattgc ctgaaaaaga aaacagcaac aggtgaaacg ataaacggca 2437021 atatgacacc cgtatatgaa tcgatcaagt gcagtccgac agtaagttta aacagaggaa 2437081 gcatcatcac ttccagcgga accatcataa taatcagcac aagaacaaag atgatatttc 2437141 tgcccttaaa atcataaacc gcaagcccgt acccgatcat cgaagaaaaa aacagagtga 2437201 gcacagtcgt aaaaagtccg agtacaagac tgttaaaaaa ccatttgaaa taaatgctgc 2437261 cgccattaaa cagaaatgtg tagttatcaa aactcatcac ttttggatca atatcaagat 2437321 tcagccccac acgcaaaagc tcagatgacg gctttaatga tcctaaaagc aaacagaaaa 2437381 tcggaaaaag atacaatagg ctcagcatca taaaaaacag ggtcagcgca attctataaa 2437441 cgctaaactg aggactgtgc cgcaacattt atccctcccc cttaaacgag cctgacagct 2437501 ttaatgaaat caggctgaca acaaggatca caatcaaaag cacaatgccg atggccgctc 2437561 cgtatcccat ttcattgtag gcaagtccct gctgatacaa atatccgaca agcgtcagac 2437621 caatattacc cggggaatta ttctgccaaa ggacgtagct ttcctcaaac atcctgaagc 2437681 cgccgatgat gctgatggtc agcacatata cggttacagg cttgagaaac ggcagcgtga 2437741 tgtgcagaaa ttttttcatt gtattcgcgc cgtctatatc agcggcttcg tacagctctt 2437801 tcggcacatt ttgcaaacct gctaaaaagt aaaggatgtt gattcccatc catctccatg 2437861 aagcaagcag caccatcaaa aacatgccgg tatgttcatt gttcatccag ttctgaggtg 2437921 aaaagccgag tttaagtagg atggaattgg ccagagacgt ttccatttct ccgaagatca 2437981 gccgaaaaat gatccccgcg acaatggttg aggtcaatgc cgggataaat aatgctgatt 2438041 taaatatatt tctaaatttg accagctttg aattcaggaa tatggccaga agcaatggaa 2438101 caggaatcag cacgatcagc gtccaaaagg tgtattccag cgtattccaa agggcggtat 2438161 agaacgtcgg gttgtttagc gctgtataat tagacaatcc gacaaaggac acctctcccg 2438221 gcaaaattct ttggaagctc atgatgaaga cactaatgat ggggtataga aaaaatacga 2438281 gaaaggataa aacgaatggc gctgtaaaca gatagggcgc cgcttttttt gaataaaaca 2438341 gatctcgcca gcctgattgt ttcgcagctg aaggaacggg atgaaccgtt cccgttttca 2438401 caggtttcat gagaacctcc ccgctttcac tttttgaatg ggattctatt tctgtttcag 2438461 ttcacctgcc gctctgtcca aggcttgttt aggcgttttt tgctgagatt taagcgcgtc 2438521 gaacaatacg cttctgttga caaggtctga agccttggca aaatcctcat gtaaataaat 2438581 tggattgatt tcatccttga tatcgagcag cacagaaaaa atgcctgttc cgttttggaa 2438641 gtaatccgtg tatttgtttt tctctttcaa ttccttggag ctccaaacat cccagcgaag 2438701 cgggtcaaag ccgagtacgc tccagagttt tttatttcct tcttcagagc ccttcgcaaa 2438761 ggccaaaaac tcttttgcta actcaacatg cttggattgc ttcggtacaa cagttgccgt 2438821 accgcccaaa cctgccgagc ggtcgccccc ctctttccat gccgggagcg gtctgatggc 2438881 aatcttccct ttcagatcag gcatataatc gataaatctt cccatatacc aaatcggcat 2438941 gagaactgaa gcagctcctc cttggttcat aaagccgtag tattcttcac tgtgatgccc 2439001 gccgcccggc gcaggaatca tcgttttatc attgatcatg tcttttaaat attgaagtgt 2439061 ttttacgttg gtgtcattat tgaggatcag cttgccgttt ttatcaaaat agcctgagtt 2439121 ttgctgtgaa atcatagata agaacgttgc ggaatcattt gtttccaccg ttcccatcgg 2439181 cttcccggtc actttgcgca ctttctgtcc ggctttatgg taatcatccc atgttttaat 2439241 atcgtcagga ttgacgccgg cttttttcat cacatccatg ttataaaaca tgaccgttgt 2439301 ccctacatgt gtatcgagtc cgtaaagctt tccgtttttg ctgtacaatg tcagccgcgc 2439361 ctcaacgaat ttatcgcgat ccttttcaat cagcggagtc aagtcggcaa gcggtatgtc 2439421 agagcccttc aaaaagtttg aaaaacgggc caattcgaca tctgcaatat caggaacgcc 2439481 ttctcccgct attagggaga tagataagtt atcgtgcatt tgtccatatg gataaacgac 2439541 cgtattcagc ttaattttgc ggtcaggata ttttttgttc cattccttca ccatttccac 2439601 atagaactgc tcatgaagcc cgttaaatgt ccaaaaggtc agctcagttt cacccgattt 2439661 gccggatgat ttttctgctg aacacccggc aatgactaat gtcagcaaca tcatgagcac 2439721 aagaaaacag acagtcattt ttttcatctg cgttacccct tccattcgag gtgcgggcta 2439781 ttcatataga ccatggttga tcagcgtttt gttttcattg atgattctta atccggtgca 2439841 tcggtctctt aaggtgtgcg cgtgtctgaa ggcatttttg acggaatcct gcccgacacc 2439901 gatttcgtca aaatacgcag ggcctccggc tgatctcagc caatcagcca gcacttctcc 2439961 tctcgggagt gtttgataag ccgattggat ggcttcccgg cggcttggtg aaaattcgtt 2440021 cagcccgtca tcctgagcga gctttctgta tgtgtcagtt aataaaacag cggcacagcc 2440081 cacctttgcc ccatgaagaa tctgaggccg ttttttctcc attaactcca tttcaatcca 2440141 atgtgaaata tgatgctcgc cgcctgatgc cggtcgggaa tgatctaatg ccagcatgac 2440201 aagccccgat acaagtaaag actccatcaa aacccgtatg ccagtttccg ttttcatcgc 2440261 aatgtcttct gtgtgttcaa tgcaggcagc aagcgcctcc tgaacgatct tagctcctgc 2440321 aggcgaataa ggctcaccgg caagatgccg ggatatttcc caatctgcta aagacgtgat 2440381 tttaccgagc atgtcaccaa agccagccgc caccattgac tgcggtgccg cttttaatag 2440441 atccagatca gcgaacagcg cagatggggc cttcgtttga atggttgttt tcgtgccgta 2440501 taaaataatc ggcgcaccgg ctgatgtaaa accgtctaca gatggagcag tcggataaga 2440561 aataaacggc aaatctcttt gaaacgccgc aaagcggacg atatcatgaa tcgtgcccga 2440621 accgactgcg atcatgacat ccgttggttg tttcgtatgg atcagcacat gaatgagcga 2440681 tcgttcatca gctgtcacat ctccggcttc attttctgga atgatcaggc actcggcctg 2440741 aaatccttct tgattcagtc ggttttctaa atcaattcct gcaatgcggt gtgtattcgc 2440801 gtcgcagaca aggacaatat gttgattgtt ttttcgtttt acataatcca aaagcgaatc 2440861 agctgcttgc ttaccgagaa caatttcttc aacttttata ggcaacgtct tttctccggc 2440921 gttttcaaaa gcacgctgaa cgtcagctgc gatacgattc atatcagaat cccctcctca 2440981 gccaatttgg ttacatcctt aatagaatcc agcacataat ccggcgtgta caaacgctgt 2441041 tcaccctgtt tcgcagaacc agttagcact aaggcgcttt tcatgccata aagcttcccc 2441101 atcgcaatgt cagattcaat gctgtctcct ataatcatgc attcatgtgc ggacagcccc 2441161 attgctgtac aggcagcctc cgccatcagc catgacggtt ttccgacaac aagttcagtc 2441221 ttcgcttgtg cagaagtctc aattgccccg atcattccgg ccacatcaat ggcatttccg 2441281 tcttcgttcg gaaaagagcg gtctttgttt gtagcgataa tacgagcgcc gccggcagcc 2441341 gcttgaaagg cttgatttaa atcgtcgtac gtgagcgttt catgaaggga gatcacgagc 2441401 caatccgctt ccttcggttc gctcgcgttc tgcacaccgg ccagcctcag ctcgtcaacc 2441461 aagccttgct ccccaagcac ccataccttt gaaaaacgat aatgtttttt cagaaaagcc 2441521 gctgtcacgc ttgatgacag aacaatgtcg tttacgtccg tttcaatccc cgcgccaaga 2441581 agtttttttc tgcacatggc acgggagata ttcccccggt tgcttaaaaa gacgattttc 2441641 tttcccattc tcctaagcgt tttgatcgct tctcttgctc cttcgatcaa ctcatttcct 2441701 ctgaatacag taccgtccaa gtcaatcaga atgccagccg gtgacacagg cgtatcatga 2441761 ctggccataa tacgcatttg ctccgtgttt tcgataaaaa tgcttttcat gcaggactgt 2441821 attgattggg gttacatcct tgttcagcat aatggagtga taggccattt cggcaaccgt 2441881 ttctaataca actgcgttat gaatggcatt taaggcgtca gtgccccagc agaacggtcc 2441941 gtgattattc acgagcacac ccggcacctg ttcgtaatta tgatgctgaa aggtttccgc 2442001 tatgactttt cctgtattca gttcgtagtc atgaatgatt tcttcatcgt acatttctcg 2442061 agtacatgga atcgcactgt caaaataatc agcatgggtc gtgcctaacg gagggatgtc 2442121 tctgcccgat tgcgcccagc ttgtcgccca ttgagaatgg gtatggacaa ttcccccgat 2442181 attcggaaag gctttatata gataaacatg ggtaggtgta tctgaagaag gtttaagcga 2442241 gccttcgacg acctctccat caaggttcaa aacaaccaag tcatcggctg tcaggtcgct 2442301 gtattcgact ccgctaggtt tgatgacaat tctttctttt tcacggtcaa tgccgctgac 2442361 atttccccac gtaaaggtta ccagctgatg ctcttgaagc ttcaggttgg cagccagcac 2442421 ttcttttttt aatgtttcaa gcatgctcca tcacccttta tcaattcttt ttggcggcag 2442481 atgaaaattg aagatttttg atcgttttca gacgcttcat gacatggttt tcttttccga 2442541 aataatgaac cagctcttta tattcagcgt acaatttttc ataaaccgcg gcgttttcgg 2442601 catttggcgt ataagttata tctttcagtt ttcccatgtt cgccgctgcc tttttgatat 2442661 catcgtagcc gcctttttct ttgcctgctg caagcgcgcc gaaaatggca gatcctaagg 2442721 ctggggcttg cggtgaacca gagattttaa tgtccatgtt tgtcacatcc gcataaatct 2442781 gcatgacaaa cgggtttttc tcagctattc cgccggctgc gaacagttcc tcaatcggaa 2442841 caccgctttc tttgaatgtt tcgataatca tccgggttcc gtaagctgtc gcttcaacta 2442901 acgctctata aatctcttca ggcttcgtca gcagtgtcat gccaagcagc atccctgtta 2442961 aatctgcatc aacaagagtt gaacggtttc cattccacca atctaaagca agcaagccgc 2443021 tttcaccagg cgcttgatgg tttgctttct cactcagcag ctcatgaacg ccaatgtttt 2443081 tttcctttgc ttcctcttga taagctggcg ggacacatgt tttcacaaac cagtcaaaat 2443141 gatcgccgac acaggactgc ccggcttcat atcccgcata gcccgggaga attccgttgt 2443201 ccacaacgcc gcacattcct ggaacgatat gcacctcttc accaagtaga acatggcacg 2443261 tcgaggttcc cataatcatc agcattttcc ctggctctgt aatgccgacc gccggtaccg 2443321 aaacatgagc gtccacattg gcaaccgcaa cagccgttcc cgggagaagc cctgtcagct 2443381 ttgccatttt ttcagtcaga ctgccggctt tttctcctac tgaatgaata gaacctgaca 2443441 atttgtcctt tgtaatcgtt ttcattgaag gatttaattt ctcaaagaaa tcatctgacg 2443501 gataccccgc tttttcactc cacatcgctt tataccctgc ggtacaattg cttcgcttga 2443561 gcgagccgca cagctggtac acgatccagt ccgcagcctc gatgatccgg tcagccgctt 2443621 cataaatgtg aggcgcttcc tcggcaattt gcatgacctt tggaatcatc cattctgatg 2443681 aaatttttcc tccgtaccgc tgtaaaaaag cctctccttc ttcttccgcg atttgattga 2443741 gccgatcagc atgtttttgg gccgcatgat gcttccagag cttcacatag ctgtgcggct 2443801 cctcttcata ttcaggcagc atgcataacg gctgcccgct gctgtcaata ggaaggatcg 2443861 tacatgccgt gaaatcaatt ccaatcccga taatgtcttt cgggtcaacg cccgtctgtt 2443921 cgagtaaaga cggaatggtt gtttccaaga cttcgaggta atcagcaggg tgctgcagcg 2443981 cccagtcacg cggcagcttt tgacccgttt ttggaaggac ggtatcaatg acagcatgcc 2444041 tgtattcttt tacagcagcc gcaagttcct cccctgtttg gacatgaacg agcactgctc 2444101 ttcctgataa agttccaaaa tcaaccccta ttgtgtaagc catgtgacat ccccctctac 2444161 ttttgaagcc ggtaaagcgc ctcgttccat tttaactcgt gtttcagttt atgaattgtc 2444221 gtatcacggg aaatgagaac actttcgatt cccgccattt ccgcccaatc aagcatttgc 2444281 tccgctgtca gttcataaga caggcaggta tggtgtgcac cgccggctaa aatccatgcc 2444341 tccgctgctg ttttcaatga cggctccggc ttccagagaa cacgggcaac cggtaaattc 2444401 ggcatgtctt tttcaatttc ctggccgttg acttcattca gcacaaggcg gaaacgcccg 2444461 ccaatatcaa caatgctagc ttgaatggca gaaccgctga tgccgttaaa taccaaacgc 2444521 gcagggtcct ctttgccgcc aatcgaaagc gaatgaacct cgattttcgg ctgatccaaa 2444581 gcgacagtcg gacacacttc aagcatgtga gagcccagaa tcatttcatt tcccggttca 2444641 aaatggtacg tgtaatcttc catgaaggaa gttctttttc ctttagccat gattttcatc 2444701 atccgtacaa gggccgctgt cttccaatct ccttcaccgg caaacccata gcctttctcc 2444761 atcaggcgct gaacggcaag tcccggcagc tgtttcattc cgtgcagcac ttcaaacgat 2444821 gtcgtaaacg ctgtgtatcc gccttgctca agaaaagcgg ttaatccaag ttcaattttc 2444881 gcctgttctt taatggacgc tacctttgct tcgtcacgtt ttgtttcctc actgatcaca 2444941 tatagtctgt catactcggc ataaagcgtg tcaacctcgt cgtccgtaat gcgatccatc 2445001 acttcaacga gatccccgat gccatatccg tcaacctgcc agccaaattg aatatgcgct 2445061 cccaccttgt ctccgtccgt taccgcgaca tgacgcatgt tatctccaaa tctggcaacc 2445121 ttaatatgtc tgctttcatt taatgcagcc gccgtatcca tccactggga catttctttt 2445181 ttcacttctt catcatccca atagccggca atgacttttc ggctaagccc cattctcgag 2445241 ttgatgtaac cgtactctcg atcgccatgc gcggattggt tgctgttcat aaaatccatg 2445301 tcaatcgtac cccacgggat atcgcgatta tattgggtat gcaaatgcat aagcggtttt 2445361 tgataagagg aaaggccttc tatccacatt tttgcagggg aaaatgtgtg catccatgta 2445421 atgatgccag cacatgtctc actgtactcc gcttctctta acagctctct aatggtttcc 2445481 ggtgaagtga cgacgggctt atgagtgatt ttatatctgg aagaaatccc gctgagcccc 2445541 tcacaaatgc ttttagcatg ctgatctacg agttccagcg tctcttcccc gtataggtgc 2445601 tggcttcctg tcacaaacca gaattcataa tcctttgtct gaagcatgta aactgcccct 2445661 ttctcataaa ataaaacgct ttcaaataca aaagatacgt actaatgata gaaaataaac 2445721 ctataaataa atatttgtac gaacaatttt attatagtaa ttgactatta tactgtcaat 2445781 cttttctttt aaaaaaagcc gggggcagag cccggctttt taattcaata ggacggccag 2445841 cccgagctcc aattcaaatc attgatgaga agctttggaa tgccgttgtc attggcatca 2445901 taggcatggc gaacaagaat gtttccgttc acaatatcct ggcctccagg tcctttccat 2445961 tggtcattgc ccgaatccaa aatggtgcct ccgccttcaa gcatgctttt tccgctttta 2446021 tcaagataag ggcctgtaat gcttttggat cttccgtaag caattttgta cgtactgttt 2446081 accccgtcac agcatttatc aaatgaaacc attaaatagt aatatccatt ttgatacgta 2446141 agagtaggag cttctaaggc acctccatta ttcggtctag ctgcaatcga atagagcgag 2446201 cctgtaggct tcattgtact cttatcgagc ttagtcagct taatgccgct ccaaaacgag 2446261 ccgaatgcaa gccacgggtt gccatcctta tcgaatgtca gctccggatc aatggcgtta 2446321 taattatttg agcttgtcga acggatcacc aagccctcgt ccttccagcc ccccgaactg 2446381 atgcttgttg aagatgccag gccaatggca gatgtattgc ttccaaaaga agaaacggaa 2446441 taatatagcc agtacttgcc gttatagtat tggatgtccg gcgcccactg gttttggcca 2446501 taattcggca cataattgga ccaccacgat agcggtgtag tgaaaatgga tttttgtacg 2446561 gtccaatttt tagcgtctga agacttcaaa acccgcagtc cccgttcttc agtaagccct 2446621 gttccgagcg cataccatga gctcccctct ttaatcatag tcgggtcatg aagcagctca 2446681 ttggatgcac cccaaaacgc tgcctctgcg ggagcagcag aagtgaatat caaacctgca 2446741 gccagagctg cactcgaaaa gtgtaagaag cgtttccatg tttttttctt tttcaatttt 2446801 gttcaacctc ctttatttta gaaagcgctt acaaattaga ttatttatcc tcccttcctg 2446861 tcaaatcgac tgcgtatcgt atatcgtcat gttcaggaaa ttttcggtat cccctttatt 2446921 gtagtcacta tgctgtaatt tgtacagaca aaaaaataga atccacctca ataggcggat 2446981 tcttccgtat ctttattggt acgtaatttc gtcaaccgtt tttcggtcta acttcttaat 2447041 gacttctgta attaacttta ccgcgttttc ataatcatca cgatgcagca tggccgcgtg 2447101 cgtatgaatg tagcgggttg caatggtaat ggacagcgca ggaacgccat ttgccgtcaa 2447161 atggatggca cccgaatcag ttccgccgcc ggcaatggca tcaaattggt acggaatgcc 2447221 ggcttcctcc gcagtggcta caactgcatc gcgcaaacct ttgtgagaga ccatggatgc 2447281 atcgtaaacg ataatctgcg ggcctttgcc cattttgctc tgcgcttcct tctcggaaat 2447341 gccaggcgtg tctcctgcta tccctacatc aacaccaaac gcaatatcag gctgaatggt 2447401 gtgtgcagcc gttttcgctc ccctcagccc gacttcctcc tgcacggttc cgacgccata 2447461 cactatattt ggatgatctg tgttttgtaa gtttcttaac acatcaatag caatcgcaca 2447521 gccgatgcgg ttgtcccagg cctttgcgag taggaatttt tcattgttca tgaccgtaaa 2447581 ttcaaaatgc ggaacgatca tatctcccgg aagtacaccc cactccaagg cttcttcccg 2447641 gcttgaagct ccaatatcaa taaacatgtc ttttatttcc actgattttt ttcttgcttc 2447701 aggagacaaa atatgaggcg gcttagatcc gataacccct gtgatttctc ctttttttgt 2447761 gacaatggtg acgcgctgag caagcataac ctgagcccac cagccgccaa cggtttgaaa 2447821 acggataaag cctttatctg tgatttgtgt caccataaag ccgacttcat ccaaatgtcc 2447881 ggcgatcata attttcgggc cgttttctgc accagttttt tttgcaatta aactgcccag 2447941 gcgatctgtt gtcacctcat cagcaaatgg ttctatgtat gatttcatca cttgccttac 2448001 ttctctttca ttgcccggta tgccttttgc atctgttaaa tctttcagca tggtcaatgt 2448061 ttcatctaat tttgccatgt tccaaaccct ccttcatcag tcctgcattc ttattataca 2448121 aaacatggcg ctaaccatac gactatttca cttgaaaatc gggtatatgt ttttacagct 2448181 ttcttttaga aaaagtgaaa cctttttcta tgcttttcgt attacatcag atcatcacca 2448241 taagggaggt gccttcacac aatgtttgtc atggttctaa ggattatttt gcttgcactt 2448301 tttgcttatt gtatttatgc cgtggtcaaa tatgtcgcga atcctaagag aaggcttaag 2448361 ctggcccaat caaaagaaca tttttatatt attgatgaac aaaacaatac ccggaagaat 2448421 tttcagctga cgtataaagg cgtgcttttt gagggagaaa agcatattcc ttccaaggat 2448481 catccgctgt ttattcacac gatctttgtc tggacagaat ctcctgagaa gctgaaacat 2448541 ttctctgcaa aagattttga gaacattgaa gaaaaagtgc tggaacgata tccaaattgt 2448601 aagattgact gggaccagcc cattaaactc gcaaaaaaag cagaagagcg ttaaacgctt 2448661 ttctgctttt tataaatcaa acgggctgta gtaaatagcg atgagaatcg cttctattac 2448721 cagaagaagc ggtactccgt acttaaaaga agcgtgtttc gttttatgtc tgaaggtttg 2448781 catgccaagc cagacaccga gcgctccaaa cacgatggct atcagccaca gccggtcttc 2448841 agaaattctc cacttgtgct gctgcgcttt gcgtttgtca atgcccatca cccaaaaacc 2448901 gcacagatta atcaacacca aataagcagc aataatcatg ttgcctcatc ctttatatag 2448961 aaaaagccgc tctgctggag agcggctcta tatgattact tgtttaattg agctttagca 2449021 gcatcagcaa gctgattgaa tgcagtaaga tcgtttacag caagatcagc aagcatttta 2449081 cggtttactt cgataccaga aagcttaaga ccgtgcatta aacggctgta agaaaggccg 2449141 ttcatgcgag cagctgcgtt gatacgagtg atccaaagtt tacggaaatc acgttttttc 2449201 tgacgacggt cacggaaagc atagtttcca gatttcatga cctgctggtt agctactttg 2449261 tataatgtat gttttgaacc gaaataacct tttgctaatt taagaacctt tttacgacgc 2449321 ttacgtgtaa cagttccgcc ttttactctt ggcattgaat ttccctccta attgttcctt 2449381 atccgattac ttgatgttag caagcatttg tttgatacgt ttgaagtctc ctgcgcttac 2449441 aacagcactc ttgcgaagct tacgcttttg cttttgagat ttgttggcga ataagtgact 2449501 tgtgtacgcg tgagaacgtt ttaacttccc agaacctgtc tttttaaaac gtttagcaga 2449561 tccgcggtga gttttcattt ttggcatggg atttcctcct tattgctttt cgtttttcgg 2449621 tgcgagcatt aagaacatgc tgcggccgtc catttttggt tttgtttcga ctgtcgcaac 2449681 ctcagcacat gcttcggaga aacggtctaa tacacgctga ccgatttctt tatgagtgat 2449741 tgcgcgtcct ttaaagcgga tagaagcttt cactttatcg cctttttcaa ggaatttaat 2449801 cgcattgcgc aatttcgtgt taaagtcatg ctcatcgatt gtcggactta accgaacttc 2449861 ttttaagtta atgatttttt gattcttgcg tgcttctttt tcctttttct gctgctcaaa 2449921 tcggaactta ccgtagtcca tgattcggca gacaggcggt tttgcattcg ctgcaactaa 2449981 cacaaggtca agatttgcgc ggccggcgat ttcaagtgct tcctgacggg acttgattcc 2450041 aagctggtcg ccattttgtc cgattaaacg gacctcacgt gcacggatac cctcattaac 2450101 caattgatct ttgctaataa tgagccacct ccatagtttc ttcgaattga ttcacaactc 2450161 attttgaatg cattttgcag gcaaacaaaa agtgtgggca ttataaaaca cccacactac 2450221 gaacatctgt atcaataaaa atgtacggtc aacctgccaa ctacatgcat gtgtcaatca 2450281 ggtgagaagc gggtgcttct gcttgtgatt tatattcaat tcaataacta ttctacacaa 2450341 taccggatct ttagtcaagg acgacttatc cggaacaact tttacattgt aacatgggtt 2450401 ttctatgagc gcaagagaga aaaagaaaat ctttcatccc cacccagaat acaaagaacc 2450461 aacaattccc ccttattacg caatttacaa caaaaccacc gacaggaaga aatgtaaaac 2450521 aaagttaatc tctgaccgat ataaggagca gaagggagcc tgacacatga acaaactgat 2450581 acagcttgct ttatttttca cattgatgtt aaccggttgc tcgaatagca gcacatcttc 2450641 cgaatcaaaa gtcgaaacca ctgttaagac aacggcagca tttcctcaaa aggagctgga 2450701 gaaagagcta aaaaaactaa aacccgtttc attggacatg aagttcgaga gtccactcgc 2450761 taccgagtta ggaaagcgga aggcaaaaga ggaagctgaa aagcaaagac aaatcgccgc 2450821 tgagaaaaag cttgaaaaag agcgggaggc gaaacgaaag aaacagcagg aggaaaaagc 2450881 ggagagacag cgattagcag agcagcaggc tgcagagaga cagcgattag ccgaagcgga 2450941 aagacaagct gaacttgaaa gacagcggca ggcagcaatc caaaaagagc agaaagcgaa 2451001 cgctgagaaa aagcggcaat cgcaggcaca acggcagcag actgaggcac cctcatctaa 2451061 tagtcaagat ccaccatctt cctcgagtca gacagataaa accattcaac agccagcttc 2451121 agagcttcct gatgacgatg gttatggtta tgaagaacga aaaaagtggc atgacgatca 2451181 agtagaatgg ggcattaaac aagggtatat cgatcccgaa gacgcaccat aaaataaaaa 2451241 aagccaaggc attcagcctt ggcttatcct ccgatcagct gcacgaacac agggatgacc 2451301 agaaccgtta ccactcctac tacgacaaca gcaatacttg ccatcgcagc ttcaacttct 2451361 cccatctcaa tcccgaccgc tacaccaagt gcatgtccgg atgttccaag agccaatcct 2451421 ttagaaatcg gatttttcac tttaaacacc ttcaagaaca atgctccgag cgcatatacg 2451481 atgacagcgt taaagatgac cgcaaaggct gtgatgtcgc tgatgccccc gatgcctttt 2451541 gataaaggaa gcgcaattgc cgttgtagcc gcctgcggaa gcatgctttt cattacggcc 2451601 gaatcgagat gaatgccttt agcgagcaga taaacaatcg tgacagagca gatagagccg 2451661 gcaataatgg aggccatgat ttgccaccag tactttttaa gcttatctct ttgtttgtac 2451721 aaaggaattg caaatgcgat cgttgccggt tcaagaaaaa acttaatgat ctctcccccg 2451781 ttattataat ccgcgtagga aaaaccgccg atttttaaaa atgcgatccc cagcaccatg 2451841 gcaacaaaca aaggagtgaa aaggaagaag cctttcgttt tcttaaataa aaaggtgccg 2451901 atgccgaatg cagcaagtga tacgacaatc ccaaaataag gactcattgt gctttccatg 2451961 tgaagaacct cctgtttccc ttaatggtga acgagttcgt tattgttctg cgggctttgc 2452021 actgtttttg ttttcatgtc cgcttcggtt ttgcgttttc cgctcagcga cagaatcagc 2452081 tgagaaaaca atcccgtagc ccccagcaaa ataatcgttg cgagcagaat gacaagaaca 2452141 atttgcaggc cgtattgctg catcacacca agcgaattca taacagatat acctgatgga 2452201 acaaataaaa atccgatcag agaggttaaa gacgttccga gcgtctccac ttgttccagt 2452261 ttaatgactt tcaaacataa taggagaaat aataagacca accctacaac cgatgccggg 2452321 ataggtattg ggacaatagc ggcaatcata tttgaaacca gcataatgac ggcaaaaata 2452381 aatgcttgtg ttaaaaaccc gtacactttt ttagcactca ttttcttcac ctctttctct 2452441 ttggtaccct cattataaat aagaattccc tgttataaag cgcttacaag ataacatgcc 2452501 gtatagcggg tctgagttgc agaatcaaat ggctgaaatg caaaaagccg cccatcaaat 2452561 atggagcagc tttttcaatt ccttcgcata tgtccggctg accggtattt tcgatccgtc 2452621 tttcatgatc agattatacg ttgaattaaa ccatggctga atttctttaa tatattcagt 2452681 attcacgaca aagctccgat ggacgcggat aaaatcagaa tccggcagct ttttctcaat 2452741 cacaacgagt gtatcgctga ccgtataaga atgatcgaag gtttttacat tgacatgacc 2452801 atcttctgtt ccggcataga taatgtcctt cgtatccaca atcacaatcg attcccccac 2452861 agatagcgcg agcttgtgct ggccggcatg gctgttttgc tctgtttcta caatatcccg 2452921 attgactttt ttatattttt tcagcgtttg ctgaattctt tcttcatcga aaggcttggt 2452981 taaataatca agagcgtcca cctcaaacgc tttgagcgca tactggtcat acgctgtcgc 2453041 aaacacaata gcaggaggat gcttcatttt cttcaatcgc tttgcgatat caaaaccgtt 2453101 ttctccggat aaatcaacgt ctaaaaacag caaatcaggt ttttgatcca tcatttggtc 2453161 aaaagcggat tcgatatttt ccgcttcatt gatttccatt tcatcattgg tccgcttaag 2453221 caagtaagcc agttcatccc ttgccagcat ctcatcatca actattaaca ccctgagcat 2453281 gttcttctcc ctctttcatc tgttgcattg gcacttgaaa ggaaacctct gtccctttat 2453341 gaacctcact gctgatatgc agtgcagcct gctgtccgaa taaaccgatc agccgctgat 2453401 ttaggttata aagcgctgta ccggttccct ccttagacgg aaacggtttc ttccccagtt 2453461 ccggcaagac gtccggcgga attccgcgtc cgttatccgc caccttcata tagacggatg 2453521 catcatcaga taagacacag actgtaacct tgcatatgtc ttgttttttc ggaaacgcgt 2453581 gccgaagcgc gttctcgaca agcacctgca aaacaaacgg agggatttca atctgctcca 2453641 gtctgctgtc gatattaagc tcaattttat atttcccggg aaaacgcgcc tgttctaatg 2453701 acaaataggc gttaagatgg ttcagctcct ttgagagcgg aatcagcagc tgtctcgctc 2453761 cttgaaggtt tgaacgaaaa taaacactga gctgcaatag gagcttacgg gttttttcaa 2453821 catctgtacg gcataacgca gaaatcgtgt tgatcgcatt aaataaaaaa tgcggattca 2453881 cctgtgcttg aagcgcttta atttcagcat ccttgagaag tttgctttgc agctctgctt 2453941 ccccaagctc aagctgtgtc gaaaacagca tggccagccc ctcggcaagt tcctcctcta 2454001 cctgactcag gcctgccggg cttttaaagt acatttttaa ggtgccgatt gtattgccgt 2454061 tcgatgtcag cggtaggaca attgcagcgt gcaaagggca ttcagcatgc gtgcattcaa 2454121 tctcttcctg cgaaatcgcc ttcataatat gccctgtttt aatcaccttt ttggacaggc 2454181 cggtgatcaa gcttttcgat gggatgtggt gatccattcc cgcaccgaca tgcgcaagga 2454241 tcttttcttt gtcagtgaga gacaccgcat ctgttcctgt cagcttatgg ataatagccg 2454301 ctacactttt acaggagttt tcatttaatc cttggcggaa aaatggaagt gtctgatcag 2454361 caatcgtaag cactcgatgc gtttcgagag cccttgcctg ttcttccttg cgaatgatcg 2454421 cttgaataat agacagaaaa ataaaactgc ctgttccatt gatgagtatc atcggaattc 2454481 cgatcatgct gacaagctcc caagcgtcac tgaacggctt tgccatcagc aaaataatga 2454541 tcatttgcag tgactccatg ccgattccca caagagcggc gatgcgcggt gtcggcattc 2454601 gatatcgctt cgtaaaatac ctgccgatca agcctgcaag aacacccgct aaaatagatg 2454661 agacggcaca gcttaaggcc gtgctgccac cgagtgaaaa acgatgcagg cccgcaagta 2454721 tgccgatccc agcccctaca aaaggacctc cgagaaggcc cccgatttcc acgcccaaaa 2454781 tacgggtatt cgcgatagag cccgatggat ctatcgtaaa cacccagtca ttgtttacaa 2454841 tcatatttct ttgaatttcg atgcctgtat aattgctgat gatgctgaaa agagaaaaaa 2454901 tagaaattaa aatcgctttt cctttatagc cgtcctgatt ctgaagagct tgtctgaaaa 2454961 gtttcgtatg ggcgagaatg aaccctaata taacaataat ccccactctc tccagcatca 2455021 taatcattaa atgaatcatt catgtcacct gttctttccg ttttcattct agcatgtttt 2455081 cgttttgcgg ctgactgttt ttttaaaatc gtctgaaaac atatttcaca aggcttttat 2455141 ctattgtaaa ataaaacatg agccttttgg cagaaagatt tgaatctgaa gcagaggaga 2455201 agatcatgaa agccgtattt tttgatttag atgatacact actttgggac gaaaaaagcg 2455261 tcagaacaac atttgcagaa acttgcttac aggcggagaa aaaatatggc cttgcccctg 2455321 aggaattcga agcagctgtt cgcgaagcgg cgagagaatt gtacatgtca tatgagacgt 2455381 atccatatac agtgatgatc ggcattaacc cgtttgaagg actgtggtcc aatttctcag 2455441 agccaatcag tgaaggcttt caaaagctga acaagattgt gccggagtac agaagaaatg 2455501 catggaccaa cggactgaaa gcgcttggga tcgatgatcc tgcatatggc gaatacttgg 2455561 gagagttttt tgcggcagag cgcagaaagc gcccgtttgt atatgatgaa acttttgctg 2455621 tactcgatca attaaaaggc aagtatgaat tattgctttt gacaaatggc gatcctagtc 2455681 tgcaaaagga gaagcttgcc ggcgtgcctg agctcgctcc ttacttcaat gaaatcgtca 2455741 tctcgggcgc attcggcaag ggcaagccgg atgtttcaat ttttgaacac tgccttaagc 2455801 tgatgaatat tgaaaaagac gatgccatca tggtcggcga taatttgaat actgatattt 2455861 taggcgcttc aagagccgga atcaaaaccg tttggatcaa ccggactgat aagaaaaacg 2455921 aaactgacgt aaagcctgat tacatcatca gcagccttca tgatttgttt cctatattag 2455981 agaaataaaa aaagcatgat ctcttcaatg agatcatgct tttttatttt attttttcgc 2456041 ttcagctact gcctttttca caaactcatc aagtgaaatg gtttcagagt tctgttctcc 2456101 gtatttacgc acgtttaccg ctccgttttc tgcttcttgg tcaccgacca ccagcatgta 2456161 cgggattttt tgcatttgcg cttcacggat tttgtagccg attttttcat cgcggctgtc 2456221 gacttcaaca cgcaggcctt cacattgcag gcgttcctgc acttttttcg cgtagtctaa 2456281 atgcacagcc ggagaaaccg ggatgacttg gaactgaacc ggtgcaagcc atgtcggcag 2456341 cgcgcctttg tgttcttcga ttaagaaagc aacaaagcgt tccattgttg aaacgacacc 2456401 tctgtgaatg acaaccggac ggtgctgctt gccgtcctca ccgatgtatg tcaggtcgaa 2456461 acgttccggc aataagaaat caagctgaac cgtagacagt gtttcttctt ttccgatcgc 2456521 agttttcacc tgaacatcaa gtttaggtcc gtagaatgcc gcttcacctt ctgcttcgta 2456581 atagtcgtgg ccgatttcat ccattgcctc tttcagcatg gattgcgctt tgttccacat 2456641 ttcatcgtca tcaaaatatt tctctgtatc ttccggatcg cggtaagaca gacggaatgt 2456701 gtaatcactt aaaccgaagt cttcataaac atcctggatt aaacggactg tacggataaa 2456761 ctcatcctta atttgatccg ggcgcacaaa gatgtgtgca tcatttaacg tcattccgcg 2456821 tacccgttga agtcctgaca gcgcacctga catttcatag cggtgcatcg ttccaagctc 2456881 tgcaatacga atcggaagct cgcggtaact gtgaatgtct tgtttgtaaa tcatcatatg 2456941 gtgcggacag ttcatcggac gcaatacaag tgtttcattg tccatttcca tcggagggaa 2457001 catgccttcc tgataatgat cccagtgtcc tgatgtttca tacagctctt tgctgcctag 2457061 cacaggtgtg tatacgtgct catagccgag gctgatttct ttatcgacaa tgtagcgctc 2457121 gatgacgcgg cggattgttg cgccttttgg cagccaaagc ggcaggcctt gtccgacttt 2457181 ttgagagttc gcgaacagct ttaattcttt gccaagcttt ctgtggtcgc gttctttcgc 2457241 ttcttctagc atacgaagat gctcttcaag atcagctttt ttgaagaaag ctgtaccata 2457301 tacgcgctga agcatttggt ttttgctgtc accgcgccag tatgcgcctg caaggcttaa 2457361 cagcttaaat tctttgattt ttccggttga aggaacatgg acgccgcggc acaggtcaaa 2457421 gaattcgcct tgctcataga tcgaaacggt ttctccttca ggaatcgcat ccaatagttc 2457481 aagcttcagg tcgtcgccga tttccgcaaa acgggctttc gcttcttcac ggctgacttc 2457541 ttttcgaacg atcggaaggt tcgcattaac gatttttttc atttctttct cgattttcgg 2457601 cagatcctcc ggtgtaatcg cttcgtccat ttctacatcg tagtaaaaac cgttttcgat 2457661 aaccggaccg acgccgaatt taacatcctt gtagatgcgt ttaatcgctt gagccagcaa 2457721 gtgagccgca ctgtggcgca taatttgaag accttcttct gagccttctg taatgatttc 2457781 cactgtaccg tcttcattga tcggcgttct caaatcgatt tcttttccgt tcagttttcc 2457841 ggctaatgac tttttcttta atcccggact gatggatgcc gcgatatctt ctgttgttgt 2457901 tcctttcgca aactccttga ctgctccatc aggaaatgtg atttttacca tatctgacat 2457961 ctttgtcact cctttttttg catataaaaa ccccgccccc tatgaaaggg acgaggttga 2458021 ataaacggaa tcgtggttcc accctttttt ccgcaaagcc aatacacggc acctgcggct 2458081 ctaagctctg taacgggagt tcccgtcagc cattactgtt ccttttcaag aggttcacag 2458141 ctgaagttca aaggcggtaa agcgaatggt ccttagctgg gaagcttgca gccagggctt 2458201 ccctctcttt gagccggtat cattccttcg tgtccttatc aatacgtgtg tctttcttaa 2458261 tctcctatgt attataaatt gttcaatcca aaaaatcaac acgatcgcgt ttcctttttt 2458321 ttaaaccgac agccttaaat agacaggctg ccggccctca tccttccgag tgcttcaccg 2458381 gtatttctgc atctgtaaaa gcatgcagcg ggagcatttc cactctctct tgaaatacgt 2458441 tttgaatggt ccttgccatc atgtgctcgg gctggtcggt ataaagcacg acttcatcag 2458501 gcgcaatgga aatcagcggc gcgagcaaat gagaatcaat atacatagga tgatcccgga 2458561 caaatcttct gtctatgtat ttcatttttt cccgttccgg cacatagcgc agctcccata 2458621 atgtaaagga accatcatgg acaatatgca cttttttgat tcgcggctgt ttggcgtcca 2458681 catagtctct gagtgtttga ataaagtttt gatattcctg ttccatctta tattcatcaa 2458741 tcgctgcttc tgtaatatct ctcagctgct tatagtatga tccaagtcgg aaggtctgaa 2458801 aggagcgaat gtaaaatact ccttcctcta aacagatcgt ttggagttca tccaaaattg 2458861 attgtttccg tgaaagcttc agcggctcaa acggaagatc gtctgcttca ccttcaataa 2458921 tactgtgtgc gagctgaagg atttgctgct gttcatcctg gtccgtgaaa caatacgttt 2458981 cctcaatcaa tgacagcata tgctcgtctt ctttgcattc caaaaaaaat ttgaccagaa 2459041 tcggctccat aaaacgctga ataggaaaag ccggattcgc tttttcaatc ccgatttttc 2459101 gtatgccttc acggacaatg atattgttcc gatcgtccga atgctgaatg agatgtaaaa 2459161 aagcggctgc atcatggtca tcttcaaaga ttatttcaag catgtttgtc cccccttacg 2459221 gcatctgtta caagtatatg ggggatgttt ttaaaataga cgtaaaggtc attggcaaat 2459281 cttaatttga ttcttggaac aagttttgca ttttctttct gaagatgaac ggcaatgaga 2459341 taaacacgat atacaaagcg agcaccataa agaaagcggg cagattgcca gccaaaaagc 2459401 tcgcacccag cacattaagc gcaatcgtcc cagggatgat tcccacagcc gttgcggcaa 2459461 aatacggcag cgctttgaca ttggaaaggc ctgccgcata gctgacgaaa tcaaaattga 2459521 tcggcaggat tctcaaaaga aagatataga aaaatccgtt atcctccatt tgcttctgta 2459581 tggcttcaag cctttcgtaa tgcccgttct ttttcgccga aaacaaacca gccgcaaaaa 2459641 acgaaacagc tgaagcgcac atcgaaccga ataacgtata aagcgtgccg agaagcgggc 2459701 caaacgcaag tccgccagct attgaaataa cagacaccgg aaataaaaca agtggcctga 2459761 cgatggatat cccgataaac atcagaggtg caaagactcc gaacgacaat acccataccc 2459821 tgatttcttt cggcgataca ttcaaatacg ttttatttcc ccaatagagt aaaccagcac 2459881 ctgcaagcac tgccagccat ttgacagccg tttttcgttt cataccctca gttccttccc 2459941 ctttgaacca cagcaattat ggatgtcggc ggttttctcc gtcaaggcgg atcggagcag 2460001 ccaaatataa tatccgctcc attaatcttg cagcttttac ttcttctttt tctcccctct 2460061 gcgaatacgt aaaatgatgc ttcagctcgt caggtgagaa attagaagaa aagaacgttg 2460121 gcagctgctg ggacattctg tgctgaagca ccgttccgat gacctcatcc cttacccagc 2460181 ttgtcattga ttctgctccg atgtcatcaa gcattaatac gggtgtggtc tttaccatat 2460241 tgagcttctc ttccaatgtc tggtcttgca gcgaattctt aagctctctc acaaattcag 2460301 gcacataaac aatcatggag gaatactctt tttccgccag ctcattggca attgcagcga 2460361 gcataaacgt ttttcctacc ccaaatttcc cgtataaata taatcctttc ccttttcccg 2460421 tctcattata gcttttcagg aagtctgtaa catgctgaaa catcgcgagt ctgcttgggt 2460481 cactgatatc aacttgctgg aacgtcgctc caagaagatc ctgctggata tacatgcttt 2460541 tcataagaga ctgttgtttc ttctgctggt cgagcttccg tttgactgga cattcgtaat 2460601 actcgatatc aatagacctc ccattgacaa caagcttcgg atggtagccc tccaacaaat 2460661 tgttgcagtt ttcatcttcc gaacaatagg agcaattctt gctttgttcg atatattcat 2460721 aaagcttatt taagctcttt tcgatcattt tttggtcaat cacttcttcg ttttccttca 2460781 aaaatgcttg aacatcttga tctttcatga ctttttcctt catttgttca agacgttttt 2460841 ggaaatccgg cctgccggtt acgccctgca gggaacggcc gattggttcc atctattcct 2460901 tcaccccgca tctctgtctt taataggcag agtatttttt cagtttttgc atttcttcca 2460961 tcatcttttt cttctgttct tccaaatcct gcggatgcag cttctgctgt ccggattctg 2461021 aatcggacgc tgtttccttt tctgtcatcc aatcaggaag cttttcttca cgaatcactt 2461081 tttggtttcg tttcgaagac tttgtttttc cctcagccca ttcaagatac tggcggtttt 2461141 cttctattgc gagcttcatc gcttccctga ccgttttcac ctttttgcgt gcccaatgcg 2461201 aagcgatttt ttggatatag tttttcgaca gcttcatgtc ggttttcagc atgacataat 2461261 aaattaacac atttgtgacg cctggctcga gcttctgttc gaacataatt tcttctatga 2461321 tcttcagatc agcttttgac ggctctgttc cgtcagcaat gtcctgcaga agcttcttcg 2461381 gggaaatcgc ctccagcaat gcaatcagct tcccatccag agaatcctct tctgccggtt 2461441 gttcgccttc acgcagatgc accggctgtg ttttttccac caaatcgggc agctgtccgt 2461501 ttctttcaat ttgataccag tcgctcgccg cttttcttaa tgcctccgtc gtaatgacgt 2461561 cacgctcatc aattgcgctc atcacaacat tttgcatttg caaagggtca attccgtaca 2461621 gataagaaag ctttttgatt gtgtcccgca cctgctgggt catcgctttt ctcggtatca 2461681 tcgtctcaga aagtcccgct aaaaacaaat caaaatcaaa cacatcctcc gttatggtgt 2461741 aggacggaga ctgtccgaca gaagtatact cggacccctc ggcaagcctt accgtttcct 2461801 ccatatcgga tgtgagcttc cattcactcg gctgcagcga ttcaaacgca tgattaaacg 2461861 gacgcgtaat gtccttcgca tcttctgaaa tggccgggtg cgtaaaaaat tgttttaatt 2461921 gctgatattt cgtttttccg accctattat acagaaaaac attcagcatt ccgtcttcaa 2461981 aaaattcatt tggtctgagc ggcggaagga gttcatatat aaagaggcgc tcctgccgct 2462041 cggattcttt catatatact ttcagcaatc cgatgccctc gagcttcccc tgttcctgat 2462101 ggatcgtttt taagttggac tgtgtcatcc ccatcagctg tctatgtgtg gactctccgc 2462161 cccacagacg gttttgttca agctctcccc acaatgtcat ataaagagag aatgcaacag 2462221 ggccgattaa gggctggtac agttgtgtaa taatttgtct gtcaatatcc tgcagcatcg 2462281 atctgctttt aaccacatac gggtctacag gcagtacatc tttccaatag tcagccatac 2462341 attctcaaac cttccgaatt tgtttctacc tttcatttta caccgtttct tatatctatc 2462401 aaatgccaat tttgcacatg agaaaagagc tagaagaatc ctcttagctc ttttaacgct 2462461 ctttctttat taagtctttt aattcatcga taaagacgtt tatatcttta aactgccgat 2462521 agacggacgc gaaccgcaca tatgcgactt cgtcaatctt agccagccgg tccatgacca 2462581 tttctccgac gagctcactc ttcacctcgg agcagccttg attgcgaagt tctttttcaa 2462641 tatcaaagca catgtcttca agcgttttga gtgaaacagg ccttttttca catgctttta 2462701 tgaggccgcg cagcattttt tctctgctga attcctcacg cacaccttct tttttcacaa 2462761 cgatgagcgg ggtttcctcc actttctcaa aggtcgtaaa ccggtagtgg caggattcgc 2462821 actcgcgtct tcggcgaatc gactttccgt catccacagg ccgtgaatca aggactcgtg 2462881 ttccgttatg ctggcatgaa ggacatttca ataaaatcag ctcccaacta tatcgttccc 2462941 tgcaatgtat tttcggcagc ctccgccttt taaaaataga tgtgacagca tctgtcggga 2463001 gagccgttgt taaatttgtt tctatagcat taggtggttt gtgaaaatct ccttcttatt 2463061 ttacaaaaaa aatgaaaaaa gaaaaagctg acactctcgt ttctttataa aaataaaagg 2463121 agcataagct aaaaagcgca taatggcttt ctagcttcag ctccctttgt gttcgcaatt 2463181 tactttatag tactttcgct tgcgcctgtt taatttgcac aggccccatt cctcttggta 2463241 tttcaatgtt ttctcttgta tcagcatgta atgcctctgc aatgtaatca gcagcgacat 2463301 taggatctaa gtctccacaa gtataaacat caatgctcgc atatccgtgc tcaggaaaac 2463361 tgtgaatcgt taagtgtgat tcagaaataa tcacaactcc gcttacgcct tgcggtgcaa 2463421 atttgtgaaa tgcaacctcg cgcacctcag cacctgattt tagagcagca tttacaaacg 2463481 ttttttcaat aaaatccatg tcattcagct tatcaaaatc gcatccccat agctcggaga 2463541 taacgtgacg ccccattgtt tccatagtca tggacccccc ttaacaagaa ttaaaaagtg 2463601 aaattccaac aactgggtcg gccatttacc acgggggaaa gttagtccgg agaggtccta 2463661 accctttaag taattccgaa acagtctcaa gcaagaagtt cacgaaaaat agtatactgt 2463721 gtttaagtct aatttgcaag gtgcgttttt tcagaaatat gctgttaagg gttttttctt 2463781 taaaatgtgt ccatgacctt attttataca gcagacggat gtttcattcg tgccgctaca 2463841 tggcggatta gatcaacaac tctgcaggag tagccccatt cgttgtcata ccacgccagc 2463901 acctttactt tcctgtcttc cattaccatt gttgtaagcc cgtcaatgac cgctgaatgc 2463961 ggattcgtat tataatcagt cgaaacgagc ggttcatctg agtaatcaag tacaccgtac 2464021 atcgacgttt tggcagcgcg tttaaatgcc tcgtttactt cttcagccgt aacatccgtt 2464081 ttcagatcaa caacgagatc aaccaatgag acgttcggaa cagggacacg caaggcgagg 2464141 ccgtgaagtt ttcctttcag atgcggcagc acaagcgaaa gcgcctttgc cgctcctgtt 2464201 gttgttggaa tgatggattc accgcaagcc cgcgcccggc gcaaatcttt gtgcgggtta 2464261 tcaatatttt tttggtcatt cgtatacgca tgaactgtag tcatcagacc gctctcaatg 2464321 ccaaactctt catccagcac ttttacaaca ggcgcaaggc aatttgtcgt gcatgacgca 2464381 tttgaaataa tgacatggcg ctcagcgtcg aattggtcct catttacgcc catcacaatg 2464441 gtaacgtctt cattttttcc cggagcggtc aaaatcactt tttttgcacc tgcttctata 2464501 tggcccatcg ctttatcttt agcattaaac ttccctgttg cttcgacgac tatgtcaata 2464561 tcatattccc gccaaggcag ctgttttgga tcacggctgt ttaacaaaag cactttcttt 2464621 ccatttacga tcaggctatc ttcaccagcc acaacctctt tgtcgtatct gccgtgaatt 2464681 gtgtcatact ttattaaatg agccagcgtt tctgcggaat agctggcgtt aatggccact 2464741 acttgaattt gatcgtctaa catcgctttt ctaaaaacca ttcttccgat tcttccaaac 2464801 ccgttgatcg ctacttttac cttcatgttg gacacccctt atcaattatg ccatcctaat 2464861 ttgttactat ctaaaattag tataacacat taaaacaaat tcgccagtac atattgataa 2464921 aaatcaacga ttataacgct aatttatgat gcatcttatg ttttcttgca cagaatatca 2464981 ggcgtaagaa ccaaaaagca gccagcgctc cgcactgact gccctcatgc tttatgattc 2465041 ctgttttaac ttatcattga gcacactttc ttctagcaca gaaaatgtat ccccgtacac 2465101 tctgttaata tgattcgctc cccaagcaca cagcatatct aaaatccctt ctaagctgcg 2465161 gccgtattcg ctgagctcgt attccacttt gggaggaact tgattatata cgattcggtt 2465221 aatgacaccg tccgcttcca gctcgcgcag ctgctgagtc agcatttttt gcgtgatatt 2465281 gggcattagg cgttttaatt cacttgtgcg tttttttccg tgcgtcagat ggcataaaat 2465341 gacgcatttc catttcccac cgatcacttc aagagtcgct tcaacagaaa tgttatattt 2465401 tttcttctcc atacaatcca ttctcctcac aggcaccaaa aagtgactat agcacttcaa 2465461 agtacgtact tttatttctt aacgatatgt ttcataatca catttgccgg ctgatttgaa 2465521 tctgctcttt tttatttata tagcttactc ggcagaattt caatcataca acacatctta 2465581 caaaggagga acatcatgac ttcagccaat aaaagcaata ttcctgcact actggctttg 2465641 gccgtaagtg cattcgcaat agggacaact gaatttatca gtgtcggcct tttgccgctc 2465701 attgctgatg acctggatat tcccgtcacg acagcaggat tgaccgtttc cctttatgcg 2465761 ctcggcgtta catttggggc acctatatta acttcattga cctcaagcat gtcacgtaag 2465821 acactattgc tttggatcat gtttattttt attgccggta atacgatggc agcaaccgct 2465881 tcaagcatcg ggattttact agcagcacgt gtgatatcgg cattttcgca cggtgtgttt 2465941 atgtcgatcg gttcgacaat cgcagcggat attgtcccgg aggataaaag ggctagcgcg 2466001 atttcaatta tgtttactgg cctcactgtg gcaactgtaa ccggagttcc ttttgggaca 2466061 tttatcggcc agcagttcgg ctggcgtttc gcctttatgg tcattatcgc cgtcggaatc 2466121 attgctttca ttacaaatgg cattcttgta ccgtccaaat tacgaaaagg gacgaaaaca 2466181 acgatgcggg atcaattgaa gcttgtgaca aacagccggt tattgctttt atttgtcatt 2466241 acagcgcttg gatacggagg aacattcgtt gtgttcacgt atctgtctcc cctgcttcag 2466301 gaagtaacag gcttcaaagc cgggactgtt gcagtgattc tgctcggata cggaatagct 2466361 attgctatcg gcaatatgat tggcggaaag ctgtcaaacc gaaatccgat tgccgcttta 2466421 ttctatatgt ttatcgtaca ggcaatcgtt ctattcgtac tgacatttac agccccgtat 2466481 caagcagcag ggctcattac cattctctgt atgggattgc tggcctttat gaacgtgccc 2466541 ggccttcagg tgtatgtcgt catgctggct gagcgttttg tcccgagtgc agttgacgtc 2466601 gcatccgcga tgaatatcgc tgcctttaat gcagggatcg cgcttgggtc ataccttggc 2466661 ggtgtgatca ccgattcaat cggattgatt cataccgctt ggataggcgg attaatggtg 2466721 gtcggtgcag tcattttaac aggctggagc cgcttgatgg aaaaacgaga tcggcaggaa 2466781 gcctgacaat tttaaaggag gaaataaaca tgacaacaca tttacaagca aaagcaacac 2466841 ttcataatgg ggtagaaatg ccttggttcg gcctcggcgt gttccaagtg gaagaaggat 2466901 ctgaactggt aaacgcagtt aaaactgcca ttgttcacgg gtaccgcagt attgatactg 2466961 cagcaatcta tggaaatgaa gctggagtcg gagaagggat tcgggaaggc attgaagaag 2467021 caggcatttc aagagaggat ctgtttatca catcgaaagt atggaatgcg gatttaggct 2467081 acgaagaaac actcgccgcg tttgaaacaa gtctgtccaa actcggtctg gattatttgg 2467141 atctatacct catccactgg cctgtagaag gaaagtataa agaagcttgg agagcgcttg 2467201 aaacgctgta taaagaaggc cgtatcaaag cgattggcgt aagcaacttc caaattcacc 2467261 atcttgaaga tctgatgacg gcagctgaaa ttaagcctat gattaaccaa gtggaatttc 2467321 acccgcgcct cacacaaaaa gagttgataa gatactgcca aaatcagggc atccagatgg 2467381 aggcttggtc acctttaatg cagggacagc tgctggatca ccctgtattg gctgacatcg 2467441 ctcaaacata taataaatct gtcgcacaaa ttattttgcg ctgggatctg cagcatggca 2467501 ttataacgat tcctaaatca acgaaggaac accgcattaa agaaaatgca agcgtatttg 2467561 actttgaatt aacgcaggat gacatgaacc gaatcgatgc actgaatgaa aacttgcgcg 2467621 tcggtcctga tccggacaac tttgattttt aatggccaaa aaacaccgtt caatatgaac 2467681 ggtgtttttt gtattatgcc cagctgttca tgatttcatc aagctgcctt ttggtctctt 2467741 caagcgtgcc gctgttatca atgacttgat ctgctcttgc tgttttttcc tctaagggca 2467801 tttgagagcg gatacggctg actgcttctt cttctgtcag ctgattgcgc ttcatcagac 2467861 gttccagttg aagctctttt gtcacactga ccacaataat tttatcaacc aatgattcca 2467921 atttgctttc gaacaatagc gggatatcca atacaacaaa tgcctcccga tttgcaacgg 2467981 cttcatcacg gcgattgagc atttcctgcc tgactgcggg atgaacaatt gcatttaaag 2468041 cgagacgttt ttgttcattt gtaaatacca gcgctccaag cttttttcta tctatatcgc 2468101 catttgagag cagtatgtct tcaccgaatt cgtcaatgat ttgccggtag gccggcatcc 2468161 ctttttctac cgcttgtttt gcaatgatat ctgcatctat aactgttatt cctttttcaa 2468221 tcagcatatt ggctaccgtg cttttgccgc tagctattcc tcccgttaaa ccaatgacta 2468281 aggtcaagag atccactcct ttttacaatt tccagagccc aatcgtgatt aatagaagcc 2468341 ccggcaaaaa cgccatttta tcgatccatt tccacttaga cagaaaatgg ccggcattga 2468401 ttccaattga tacaaacagc gagctcatga ttgccacggc gatgctcatc acaatcggcg 2468461 aaaaaccgag aatggctgcg cctatacctg ctccaaaggc atcaatcgat aaggcaaatc 2468521 ccaataagac cgcctcaatt ccgttgatca cacccgattt gtcgatatcc gcactcatgg 2468581 gttttctcaa aatatgaatc acaattccta atgaccgaac ctctagatta agcagtgttt 2468641 tttcatgcaa taggtattct ttatcttttg ccggtttgaa aaattgatac agaacccacg 2468701 caccgattcc aaccaatatc aaaccgccaa gcttctccgt cacatataca ggaaaaaact 2468761 tcgtgagaaa gcttccgatc agcatggata taaacatgac agcaccggaa cagcaggcga 2468821 taaccaaaat cgctttaaac ggtattttca tttttctcaa tccgtacgta aatccgactg 2468881 aaaaactgtc caagctgaca gccaacgcca gcagcagtat agaaaccatt tgcatatccg 2468941 tttcttcctt tctgttggtg ctcttgtatc agatgtgaaa tgcccgggat tcatcacaat 2469001 catatatatg ggaaagtgaa aaatccgtgt ttcgaaaatg gcatccttaa tccagagtta 2469061 ctgatatatg caccgacagc ttggacaatg aagcattatg ctactttttt gtctggcact 2469121 ttgcgcaaaa atgcgtgcct cttcctccaa cgacaatttt cgaaatcatc gttccgcaat 2469181 ttttgcatgg ctcgtctttt tttccgtaca caaaatgctg cagctggaac attccgattt 2469241 ccccttggga gttgatatat gaacggactg tgcttccgcc cgcatcaatc gcctcctgca 2469301 gagtgttttt gatttcagcg tgaagggttt tgattgtttt atctgataat tgatttgctt 2469361 ttgtctcggg atggacaccc gctctgaaaa gagcctcatc cacataaatg ttcccgagtc 2469421 caactaccgt tttttgatcc agtagggcag ttttgacagc gcggtttgtt ttcgcaagcc 2469481 ggtcttttaa atacgcactt gtaaattctt ctgcatccgg ctccggccct aactgagaaa 2469541 gcgggagctc gcccgcttct tctcccggtt taaataagtg catggttcca aatttccgca 2469601 catccctgta ccggagctgg gttccatccg tcatcgtgaa tatgacatgc acgtgtttat 2469661 cgtcaggctc ctcggcttga tgaagaccgt attttccttc cattcgaagg tgagaaacca 2469721 taacataatg atctaaatga aacagtaaaa actttccccg tcttccgatg gactgtatcg 2469781 tttctcctgc tagttttcgc gcaaattcct ccggttcggc aggccgtttg atgatattcg 2469841 gccatctgat ctctaccgat ttgattgttt ttccctttac aagcccggtc agagtgcgcc 2469901 ggaccgtctc aacctctggt aattccggca catccatcac ttcctatctc tgtttatttc 2469961 gcatcgtacc aagatgggcc tgatgcaaag tccaccttta acggcacatc taatgcaagc 2470021 gcatgctcca tcacttcagg aacaagcttt tcaagaattt caatttcttc ctttggcgcc 2470081 tcaaaaatca attcatcgtg tacttgaagc agaagccttg ctttcaactg tttttctttc 2470141 agcttggcag ccatgtcaat catggctttt ttgataatat cagcggcgct tccttgaatc 2470201 ggcgtattca tggccgtccg ctccgcaaaa cttcggatat taaagttccg gctcgtcagc 2470261 tcagggatgt agcggcggcg atgcataagc gttgttacgt atcctttttg tttcgcttcc 2470321 tgtactgaat cttccatgta cgcttttacg ccttggaagc tttccagata gcggtcgata 2470381 aatgctcccg cttccttccg ggtaatgccg aggttctgtg acagaccgta atcgctgatc 2470441 ccgtaaacaa tgccaaagtt gaccgctttc gcctggcgtc tcatcgcaga tgtcacttca 2470501 tccttagcga catggaacac atccattgcc gttttcgtgt gaatatccat atcattagta 2470561 aaagcttcga tcagattttc atcctttgaa atatgggcaa gcacccgcag ctcgatttgt 2470621 gaataatcgg ctgcaaaaat gagccagtct ttttcagacg gcacaaaagc ttggcgaatt 2470681 ttccgccctt cctcaagcct gatcggaatg ttttgcaggt tcggatcagt cgagctgaga 2470741 cggccagttt gcgttaaggc ctggttaaat cgcgtgtgca ctttatgcga atccggtctc 2470801 gtcaccttta aaagcccttc gatatatgtt gattgaagct tgccaatttg tctgtactgt 2470861 aaaatatagt cgacaatatc atgcttgtca gccagctttt caagcacatc ggcagacgta 2470921 gaatagcctg ttttcgtttt ctttacgaca ggaaggccga tcttttcaaa taagatgacg 2470981 cctagctgtt tcggagaatt gatgttaaac ggctctcccg caatctcatg gattttttct 2471041 tcatattcct tcagcttcgc acccagttct tcacccatcc gttttaaacg gtcaacatcg 2471101 accttgacgc cagttgattc catttcgcca agaataagcg caagaggcat ttccagctct 2471161 tcaaacagtt caagctggtc gttgttttcc agctcttgaa cgagcttttc ccgaaggctt 2471221 tgaatcgcta acgcttttcg gccaaggtgc tcagacagta cgtcttctga cggcactgcc 2471281 cgttttgctc cttttccata aactgattca tcacttgaaa cgatatgcag gccgtaatcc 2471341 ttagccacac tcgcaacgtc gtcatatgaa ttgcccgggt tgatgatata agccgcaagg 2471401 agcgtatcaa actcggctcc tttcagctca atgccctgcc agcgcaaagc gacaacggcc 2471461 cgcttgctgt cgaagaccca tttcttctgc tcgtcatttt ccacccattc tttaaacacc 2471521 tcagactcaa cggcaatgtc tttcggaatg aaataagctc ccgtttcatt tacgatcgaa 2471581 aatccgagga tcggctcttc atgataatta tcgccaatct gttcaacgac aaatgcggat 2471641 ggagaaacca atatatcgct tgtcacgtct gtgactgttt tgacattaat gtcttccaac 2471701 gattgatcct gttctgcttc tgcactgtct tctccaagcc gttcaagaag cgtgttgaag 2471761 ccaagatctt taaagatggc aatgacctgt tcacgattaa agccttgata ttccaggccg 2471821 gaaacagata cctcaatcgg agcatccgtc ataattgtcg caagctcctt gctcatcaat 2471881 gcctgatcct taaactcctc aagcttttcc ttcaatttct ttccgctcac ctcgtcaatg 2471941 gactccagca gcttttcaac ggaatcaaat tgttttaaaa gcttaatcgc agtcttttct 2472001 ccgacgccgg gcacacccgg aatattatct gaggaatcgc ccatcagacc cttcatgtca 2472061 atgatttgtt caggcgtaag cccatatttc tctttgacat gctccggtgt gtaaaattca 2472121 acatcggtaa ttccctttct cgtaatggca actgtcgttt tgtccgttgc cagctgggtt 2472181 aaatccttat ctcctgagaa aaccttaact tcaaatccgt ctttttcagc cgatttggcc 2472241 agtgtgccga taatatcatc cgcttcatat tgttccagtt catagcggct gatctggtag 2472301 gcatccagca gctcgcggat aaacggcatt tgttcggaaa gctcaggcgg ggttttctgt 2472361 ctgccgcctt tatattcttt aaatgtgccg tgacgaaatg ttgttttccc ggcatcaaac 2472421 gcaaccagca tgtgcgtcgg tttttcatcc tcaagcattt tcatcaaaat catcgcaaag 2472481 ccgtatacag cattcgtatg aacaccttta tcattgctta acagcggcaa tgcaaaaaac 2472541 gcccggtaag ccagactgtt tccgtctaca agcactaatt tttttcgttc cgtcattcaa 2472601 tttcctccta agaagcctca ggcttccatt catctcttac atagtcatta gctcctctta 2472661 ttttaacaaa gttcaatttg aaaggaaaat acgtgaacta taagagaaga cacaaaaaag 2472721 gacgggaaca caaataggtt cccgccgtca aaattggctc cttggatgaa ggggttctac 2472781 tacatcctac cagcataggt ttaacagtgc atgaagatat tgttaaacct ttgtaaacat 2472841 taggcggact tttcagcggc ccgtttcagc gtcacggtaa agacagttcc ccgtccaagc 2472901 tcgcttgtga catcaatttt cccttcatga gcctctatta aatgcttgac aatcgctagg 2472961 cccagcccgg ttccgcccga atttctgctt ctgtctttat ctacacggta aaagcgttca 2473021 aagatgcgcg gaatttcttc tttctgaatt ccgattccag aatcggcaac ctcaatctga 2473081 atgtcttttt ctctgggctt tacattgata gccacggagc ccccctcagg cgtgtaggtt 2473141 aatgcattgt ttacgagatt aagaaatacc tgtttcagcc tgtacgggtc accagataca 2473201 tattgagggt ctttcgggac attcaggtgc aaggagatgc ctttctcatc cgccttatgc 2473261 ttcagaagcg tttcaatctc accaagcatt ttggccggct caaacgtttc gatactgagc 2473321 gtgaaatttt gctgctcgat ttttgagaga tcgagcaaat cctgaaccaa agactgaagc 2473381 ctttcgcttt ccttaagaat aatagagaga aattcagaaa gcgcctcttt gtcttccatc 2473441 gccccgtcca ataacgtctc cgtaaaccct tttatggacg taatcggtgt tttcagctca 2473501 tgagaaacat tggccacaaa atccttcctc atctgctcta atttcttcgt ttccgtcatg 2473561 tcatggaaaa cgagcacaat tcctttccat tcatcgtccg gccccataat cggaacgccg 2473621 tccacttcaa aataacgccg ttctattttg atcggcagtc ttaacagctt gcatttcttt 2473681 gtctccgtca taaaaatgtc ttcgacaagc tggatcactt cttcatgttc aaatgcatcg 2473741 tgataaagac ggcgcagcat atgattcgga ttgatatgaa actgcttggc gtaagacctg 2473801 tttacgagat taataaagcc tcttccgtcg atcataatca gcccggagcc aatgttttca 2473861 atgactgtca gcagccgatc ccgctgcatt tcctgcgttc gcgtcatttc catcagatca 2473921 atggcaaggc tgttcatcgc atgtcctagc ttatcagaac gcctaatata gccgccgtac 2473981 gtccgtgcat cgtagttgcc cttagagagt tctgtggcta catttgtcgc tgactcaatt 2474041 gaccttttat aacgtgaggt catgctggaa taaaaataaa caatgacgat aaatgcggta 2474101 caaagactgg ccgtcagcat cccccacaat tcgcctttta agccgtcgct tttttcagag 2474161 gcggaaagca gcacatatcc tgttttttca ccttcgcttc taagtgaaag tccgtaataa 2474221 agcttgttat ctgttgttga cagaataccc tcatggccag aaacaagcgc ctgcaccttt 2474281 tgggaatcag ccgatctacc gtttgaccca tacagcacct taccgtctgt atcgataacg 2474341 gatgcgctca catcaagcgc gccgcctgca tctttaatga ttttctcatt tgcttgatta 2474401 ttcagattgc cggcatcaag aagcgaagcc aagtattttg cttctttttc aatgtgttcc 2474461 tctgctttcc tttgatcaga tgtttcaaaa agctgctgta aaaacagccc gaggacacaa 2474521 aacaccagaa tcatacagac aacgaataca gaaaaaaggc gcacacggta tttattcatt 2474581 catttttggc tcctccagtt tataccccaa tcccctaatc gttttaatgt agatcggttt 2474641 tttggtattg ttttcaattt tgtcgcgaag atggctgatg tgcacatcaa caattctcgt 2474701 atctccggca aaatcataat tccagactgc gctcagcagc aggtctcttg tcagaactct 2474761 gcctttatgt ctgcctaaat agagcagcag ttcgaattct ttcggtgtca gttcaagctg 2474821 actttcttta aagtacgctt cataatgatc aggcaggatt ttcagatcgc cgattacgat 2474881 ctggccttcc atttcatcgt tcttcatctc actagagggc gcagctattt ccgaacgcct 2474941 taaaatcgct ttgactctcg catttacttc ccttggactg aacggcttgg tcatataatc 2475001 atcagcaccg agctccagcc ctaatacttt gtcgaattcc tcatccttcg ctgtcagcat 2475061 taaaatggga aacatcagtt tttgctgtct cagctgcttg catacttcga ttccgtccaa 2475121 ttttggaagc atcacatcaa gcacaatcaa atcaggtttc tctgtttccg cttttttgag 2475181 tgcttcttcc ccatccgagg cggtaatgac atcatagcct gaccgttcca aattgtactg 2475241 taaaagagta acaatagatt cttcatcatc cacaactaaa attttcttgt tcatgctgtg 2475301 cctccagtat tataattccc cgacatccta tttctctatt ttatgtcatc ttaacatgtt 2475361 tcatgatttt attttagcga aagcaggaca ttccgacaat tcgcctttta catcattttt 2475421 aaaagaaata aagacgttta tgatagcgct ttcatttata gtaaaaagag aaaggctgta 2475481 ttaagcaagc ctttctctct ttttattagg ataatacttt catgacattt ttgacagatt 2475541 caactgattt attcagctgc gctctttcat agtctgtcag ttcaagttca atgatttgct 2475601 caagaccgtt gccgcctaca attgtaggaa caccaaggta gatgccttca tagccgtatt 2475661 ccccttcaag ataagcaatt gtaggaagga cgcggcgctg atctttcaag atcgcttcga 2475721 ccatttctgt cagagaagcc gcaggcgcat aatacgcgct tccgtttcca agaagattca 2475781 cgatttcgcc tccgcctttt ctagtgcgct ccacaattgc gtcaatccgt tctttcggaa 2475841 taagagtttc aagcgggata ccgccagcat aagaataacg cacaagcgga accatatcgt 2475901 caccgtgtcc gccgagtacg aaaccagtca catctttcac tgacaggttt aattcctctg 2475961 ccacaaatgt tctgaatctt gccgtatcaa gcacacctga ctggccgatt acacgctctt 2476021 tagggaagcc tgattctttg tacaccgcgt atgtcattgc atcaacagga tttgtcagca 2476081 ccacaataat agagtcagga gaatatttca cgatttcctg cgtaacgctt ctcataatct 2476141 tttcgtttgt agagaccaga tcatctctgc tcataccagg ttttcttgcg ataccggctg 2476201 taatgacaac aatgtcagag ccggctgtat cctcgtaatt ggatgttccc gtaatttttg 2476261 cgtcaaagcc ttgaaccggg cttgcttcaa gcatatcaag cgcttttccc tttgtcgggt 2476321 tctccaattg cggaatgtca acaagaacaa cgtctgccag ctctttttga gcgattaaaa 2476381 atgcagttgt agctccggta aaacctgctc cgataacaga aactttttta cgagtatttc 2476441 ccatgtctct cttctccttt atggctagtt ttaggctttt tccttgctta gtccatgttt 2476501 ttgatcagtt cttctccgaa ctctgaacat ttcacttcag tcgccccgtc cattaatctg 2476561 gcaaaatcgt aagttacgac tttagaagcg attgtttttt ccatagattt gataaccaaa 2476621 tcagccgctt cgttccatcc taaatgctca agaagcagaa cgcctgaaag aataactgaa 2476681 gatgggttta ctttatcaag gcctgcatat ttaggagccg ttccgtgcgt cgcctcgaaa 2476741 atcgcatgtc ctgtttcgta gttgatgttc gctccaggag caatgccgat tccgccgact 2476801 tgcgcagcaa gagcatcaga aatgtaatct ccgttcaagt tcattgtcgc aacgacatca 2476861 aactcgtttg gacgcgttaa gatctgctga aggaaaatgt cagcaatgct gtctttgata 2476921 atgatttttc ctgctgcttc cgcttcgctt tgcgctttgt tggcagcgtc ttttccttgt 2476981 tcttcagcaa tgcggtcata ttgagcccat gtgaagactt tatctccgta ttctttttca 2477041 gcaagttcat agccccagtt tttgaaggcg ccttctgtga acttcatgat gtttcctttg 2477101 tgaacaagtg ttacagattt gcggccatgc tcgatcgcat aatcaatggc agctctgacc 2477161 aagcggcttg ttccttcttc tgaaacaggc ttaatgccga tacctgatgt ctcagggaaa 2477221 cggattttat tgacgtttaa ctcattttga aggaagctga taagcttttg cacttcttca 2477281 gagccttttg catactcgat gcctgcgtaa atatcttctg tattttcacg gaagatgacc 2477341 atatcagtat cttcagggcg ttttaccggt gacggcactc cagtaaagta tcttacaggt 2477401 cttaagcaga cgaataggtc aagctcttgt ctgagcgcta cgttcaaaga acggataccg 2477461 ccgccgacag gtgtcgttaa cgggccttta atcgcgatga aatattcgcg gatcacatct 2477521 aatgtttcag cagggagcca ctcacctgtt ttattataag ccttttctcc ggcgtaaact 2477581 tctttccatg taattttctt ttcgcctttg tatgcttttt ctactgctgc ttccaaaacc 2477641 ttcgaagccg cgttccaaat atcaggaccg gttccgtctc cttcgataaa tgggataatc 2477701 gggttgtttg gtacgtttaa tactccgtta gagactgtaa ttttttcacc ttgtgccaca 2477761 ataaaaacct cccagtatgt aattcatatt tagaaaacat tttatttttc ttatatagaa 2477821 aataaaatga tttttcctaa cattcaattt aaagtgtaac ccaattttga tgtctgaaca 2477881 agaggctaac ctcattgacg caagccagcc tccaatggtt ctttaggctc tttcttcaat 2477941 cggaacgaat ttttgtttgt cagggcctgt gtaatctgcc cgcgggcgga tcagacggtt 2478001 gttgtcatac tgctcaagaa tatgagcgag ccagccggac attctgctta cagcaaaaat 2478061 cggtgtaaac aaatcatggt caataccgag gctgtgatat acagaagccg aatagaaatc 2478121 aacgttaggc ggaagctttt tctctgatgt gacgatgtct tctatacgaa tcgacatctc 2478181 ataccatttg ctttcgcctg tcaggttggt caggcgcttg ctcatttctt tcagatgctt 2478241 cgcgcgcgga tcaccatgct tatacacacg gtggccgaat cccatgattt tttctttctt 2478301 ttcaagttta gcgcggatgt acggctcagc gttttccact tcaccgattt ctgtcagcat 2478361 tttcataacg ccttcattcg ctccgccgtg aagaggccct ttcagcgcgc cgattgctgc 2478421 agtaatgcct gaatagatgt cagaaagtgt tgcgacgcag accctcgctg tgaacgttga 2478481 cgcgttcagc tcatggtcag catgtaaaat caatgctttg ttgaaggctt caacttcaat 2478541 tggtgaaggc tcttcaccgt ttaatgtgta aagaaaattc tccgcaatac cgtaatcttc 2478601 tctcggttca acaggctcaa gacccttgcg aattctggaa aacgctgcaa ccaggccagg 2478661 cacctttgcc tgaaggcgga tcgcctttct gtagttggct tccgggttca tggtatcagc 2478721 ctcgctgtca agcaggccta gtaatgaaat tgctgtccga agagcagcca tgggatgaac 2478781 attttcgagg gaataagatt tgaagtgctc aataatttct tgcggaacgg cagcttcctt 2478841 tgcaagctgc tgctttaact cttcaagctc ttttttgttt ggcagcctta gatgccaaag 2478901 caagtagatg atttcttcaa aacttgcatt ctctgtcaaa tcatcgatat cataccccac 2478961 atatgtaagg gtatcatcaa taatagaact aacagatgat gttgttgcta caaccccttc 2479021 aagaccgcgt gtcgctgtca tatataacat ctccttttca ataaatttcc cctttaagag 2479081 tgttgtaaaa acatgaggct tacttaaaaa gcacgatgca agtatttctc tcccccaaaa 2479141 agaaaatgct tacattttac tggctgctgg aactaaaacc ctttgctttt gaaagaacat 2479201 aacaaatttt tataagctta tttaagttta agcctattct cattataaac aataatcaga 2479261 catttgttaa atgtttacct ataatttttt ttttccattc tgtgatttcc ccgaaaaaac 2479321 gcctttattt gcgggttttt gcataaaaaa aagcggcttt aaggccgctt ttttttatga 2479381 agtgaacagt tttacgatct gcatggctaa ataagcaatc cccgctccga tcagcggccc 2479441 caccgcaact cctccaaaaa gcgcgactgc aagaatggtc ccgatcacga gagcagttgt 2479501 aatatgcgga tcattttcaa gcagggtcag gccgtttttt gcaatcagcg ccactgcgat 2479561 ccccgctcca agggcgatcc atgcgtagga agaccgcatt gcttctccaa gctgcttaaa 2479621 tccgatttct cccgtggcaa tcgggacaag aacggcgatg gtaataatgg tcacacccca 2479681 gttaatgcct tttgactgga tggtcggaaa taatttctga tcaagcccaa cgattttgat 2479741 gatcaaaagg acggatacag caaagagcaa tgattggttt tttgcgataa gtgcgatagc 2479801 caagagtaaa attaaaaata aattcgcttg tgtaaacaca tgccatccct cctttaagat 2479861 gaatgtattc atattcagcc gcagcgtgaa tacatataaa aaataggaca tgctgacgag 2479921 aggaggaccg tttttgtgaa tcaatcttat atcactattt ttttcagaac cctctttgtc 2479981 atatcaatga ccgcagggtc gatagctgcg gcctattatt cgtttccgtt aacttatccg 2480041 ttcctgatcg cccttattct atcttcagtg attcatcctg ttgtcgatta tttggacaaa 2480101 gtgacaggat tcccccgaac gataaatgtt ctgggcgttc ttgctttttt tctgctcgca 2480161 gccttcggcg tgctcaccat tctggtagcc gaaatcgtaa cgggaacagc ctatctagca 2480221 aaaacgctgc ctccgcatat cagcacgttt atttcatatt gcgaaaaatt gtttaccact 2480281 catattcagc cgctctataa cgagttaact cttttgtttc aagaattgga aacgaaccag 2480341 caggcttcca tcgtcactca tatccagaca ctcggtgatt ctgccgctaa aaatgccggg 2480401 ctcctgctgt cccacattct agagatgatc ccgagatttt tcgctcttct tcccaatacg 2480461 gcggcggttc tgattttttc tcttctggca acctttttta tgacaaagga ttggcataag 2480521 ctgaaagcca tgcttgtttt aattctgccg gatcgtgtga cagctaacag caaagcaatc 2480581 agcagcgaat taaaaaaagc aatgactggt tttatcaaag cacaagccgt cctcgttttc 2480641 atcacgatgg tgattgtatt tatcggcctt tctctcttaa aggttgaaca cgccgcaaca 2480701 attgcttttt taatcgggct tgtagatctt ctcccttact taggtgccgg ctccgtattt 2480761 gtgccctgga ttttgtattt atcgattacg ggccagctgc cccaagcaat cggaattggt 2480821 atcctgtacc tcgtcgttct tattcagcgg cagctgacag agcccaagat actaagtaaa 2480881 tctatcggga tcgatccgct ggcaacactc atcgccctgt ttgccggctt taaattattc 2480941 gggtttttag gactgattgc gggaccggct gtactcgtca tcatccaagc tttcatcaca 2481001 acaggcgcat taaaagaaat atggtcctat atcaccgttc agcaaaaata aaacggcagc 2481061 cgttttttca tggctgccgt tttttatttg atgatgatcc gcttattctt cgacattcct 2481121 ctcagccatt tgaacagaat cggcttacac cagccgcggg taaacgggat aagaagacag 2481181 gcgccggcca aatctgataa aaagcccgga agcatcagca atagaccgcc aatgaaaatg 2481241 cacagaccgt cagcaatcgc ttctcccggc attttgccat attgaagatc acgctgaacc 2481301 ttataataca cttcggttcc ttgttttttt gcagctgctg cgccgataat gccagtcaga 2481361 atcatgaata gaactgtcgg caaaatacca atcagatttc ctaaaaatag gaatataccg 2481421 atttctattg ccggaaacac aataaaaagc aaaaacaaaa atctcatatc caagcccccc 2481481 acacgtgtaa cacgttctgt tcaacaaaag gcatgataaa gagaaaagga agggattccc 2481541 cttccatttt cacctgtaat taaagaacgc tcgcacggcc ttgatagact gcgcctctgg 2481601 aagcgtcaac tgtaatatcc tggccatctg tcaaaataga tgtcgcattt tccagaccca 2481661 cgataaccgg gatgccaagg cttaatccga ctaccgcagc atggctagtc aaaccgcctt 2481721 cttctgtaat aagagcagac gctttttcaa gggatgcaat catatcacgg tcagtgcttt 2481781 tggtaacaag taccgcaccg tcagtcattt tttgctcagc ttcttttgca ttttgtgcaa 2481841 cgacaaccgg accgtaagct gatttgcgtc caatgccttg gcctttagcg atgatatcgc 2481901 cgacagtatg aaccttcatt aagttcgtag tgccggactc accgacagtg ccagctgtaa 2481961 taacgataag atcgccgtgt tttacaattc cgctgttcaa tgatttttgg acagcatcct 2482021 caagcatctc atctgttgag ctcgcatttt ggccgctttc cgcgaatacg ccagatacga 2482081 gggcaagctt tctggaaata gagtcattta cagtaaccgc aacaatcgga gcctgcggac 2482141 ggtattttgc aatcatacgt gctgtatggc cgctttctgt cggcgttacg atcgcagcag 2482201 cattcaggtt aatcgccgta tgtgcgacag attgtccaat tgcgtctgta attgtcatgc 2482261 ccacttggtc tctgcgtttt gagagaattt ctttataatt taatgcttct tcagaacggg 2482321 acgcgatgtt atgcattgtt tgaactgctt caaccgggta acttccggca gcagtttcac 2482381 cagaaagcat gatcgcatct gttccgtcga agatcgcgtt tgcaacgtca cttgcttccg 2482441 cacgagtcgg acgcgggttg cgctgcatgc tgtcaagcat ttgtgtcgct gtaataacag 2482501 gtttgcccag cgcgttgcat tttttgatca gttctttttg cacaagcggc acttcttcag 2482561 ctggaatttc cacacctaag tctccgcgtg caaccattaa gccgtcagac acttcgagaa 2482621 tcgcatcgat gttgtcaacg ccctcttggt tttcgatttt agggatgatt tgaatatcct 2482681 gagcgttgtg ctcttcaaga agctcacgga tttcgagcac atccgtagaa cgtcgaatga 2482741 aagatggtgc gatgaagtct actccttgct caataccgaa aacgatgtct cgcgcatcct 2482801 tttcagtaat ccccggaaga ttgacactta cgcccggtac gttaacacct tttttatttt 2482861 tgagtgttcc gttgtttaat acttttgttt tgatttcgcg tttagcggca tctacatcaa 2482921 gtacctcaag accgataagg ccgtcatcta acagaatcgt tgaaccttgt tcaacgtcat 2482981 ggactaaacc ttcatatgtc actgaaattt tatctgttgt tcctacaacc tcgtccattg 2483041 aaataatgag ctctttgcct gtttcaagct caataccgcc gttttccatt gtatgtgtgc 2483101 ggatttcagg accttttgta tcaagcagaa ttccaacgtt cttgccaagt tttttacttg 2483161 cttcgcggat atttttaatt cttgcaccgt gctcctcaaa atctccgtga gaaaagttta 2483221 atcgagccac gttcattcct gactccatta atttcgtaag catttcaata ctttcacttg 2483281 ccggaccgat ggtacaaaca attttagttt ttctcatttg gttcacttcc ttctgaaatc 2483341 ttcagccttc agctgtacat tagatagaca gttcttttga aagctgatac atgttttgct 2483401 caactgtgtg ttttgtctca agtatttcta taatatcatg gtctacaagc ttattgtttt 2483461 gtatacctac acagcgtccg ccttttcctt caagcagcag ttcaactgca tatgcgccga 2483521 gacggcttgc caacacacgg tcagcagcac tcggagaacc tccgcgctgg atatggccca 2483581 atacagatac cctagtttca agatttgttt cttcttcaat gcgtttcccg aattcaacac 2483641 cgctgcctac accttcggca acaataataa tactgtgctt cttgccgcgt tcgtggccgc 2483701 gttttaagcg ggcaatgatt tcgtgcatgt catagtctgc ctcagggatt aagatcgatt 2483761 ctgcgccccc tgcaagaccg gcccacaatg cgatatcgcc ggcatgacgg cccattactt 2483821 cgattacata tgtacgttca tgagaagtcg ctgtatcgcg aatcttatca attgcgtcaa 2483881 ttactgtatt taaagctgta tcgaaaccga ttgtaaaatc agtgcccgga atgtcattat 2483941 caattgtacc cggtacacct acacatggaa acccgtgttc cgttaatttt ttcgcaccca 2484001 tataggaacc gtctccaccg ataacaacaa ggccttcaat accaagcttc ttcaagtttg 2484061 ctatcccttt ttcacggcct tcaactgttt tgaattcagg acatctcgcc gtataaagct 2484121 tagtccctcc acgatgtata atatcgccta ctgatccgag ttcaagcttt tcaatctttc 2484181 cgctgatcaa tcccgcgtat ccgttgtaaa taccgtaaac ttcaacgtca tgatagatcg 2484241 cttttctgac tactgcgcga actgctgcgt tcattcccgg ggaatccccg ccgctcgtta 2484301 atacccctat tcgtttcatt ctccattcac ctcagcaaca tatatgatta aacataacat 2484361 gatcattgcc ctaaaaacaa tgaaaaggga tctccatcct ccctatgaaa ccttacctat 2484421 tatacaatta aataaattgt ttttaaataa aatttaagga atgtcacaaa aaataaacgt 2484481 gagccaaagg cttcacgttt atttagttta ccccgatata ttgatcttca accgagactt 2484541 tgccaattgc tttatatttt tcataacgct gctgaactaa ttcttcttcg ctcagcttca 2484601 gtaaagtttt taacgattgt ttaagggttt cgtccatata gcttgcctgc agcttcacat 2484661 catggtgcgc tccgcctttt acttctttaa tcatatgatc tataatacct aattctttta 2484721 aatccggcgc agtgattttc attgtttctg ctgctttttt agcaagactg gagtccttcc 2484781 ataaaagtgc cgcggcacct tccggagaaa taacagaata agtagagttt tccagcatat 2484841 gcaagtgatt gcctacaccc agaccaaggg ctccgccgct tccgccttca ccaatgacga 2484901 tgcagataac aggcactcga aggccggcca tctcaaacag gtttttggca atagcttcac 2484961 tttgtcctct ttcttcagct gctcgtccag ggtatgcccc cttcgtatca ataaaacaga 2485021 taattggtct gttaaatttg tcagcctgtt tcatcagacg aagcgctttt ctgtagcctt 2485081 ctggatgcgg catcccaaaa ttgcggacta ggttttcctt cgtgtctttg ccgcgctgat 2485141 gcccgattac cgttacaggg aggccgtgga acttcgcaat cccgccgaca atggcttcat 2485201 cgtccccgta cgctctgtct ccgtgacatt caaaaaagtc ggtaaacagg tgttcgatat 2485261 aatcaagagt tgtcggacgg tccgccagac gcgcgatttg aacccggtcc cacggcttca 2485321 aatttttgta aatatcatcc tgaagcttag cgagacggtc ttcgagccgt tcgatttccg 2485381 cacttagatc catatcggaa tcttgggtga atttttttag ttcggcgatt ttggtttgca 2485441 gttcaatcac cggtttttca aattctaatc ttggagccac tcaatgtcac ctcctgtttg 2485501 atgcatatcc agcagatttt ctaacgtttt tttcatatcg tcgcgatgaa taaccgcatc 2485561 aagctgtcca tgttttaata aaaactcagc cgtttggaag tcctcaggca gtttttctcc 2485621 tattgtctgt tcaataatcc gtcttccggc aaaaccgatc agcgcgccag gctcagcgaa 2485681 attgtaatcg ccaagggatg caaagcttgc tgatacgccc ccggtagtcg gatgcgtcat 2485741 tactgaaata ataagaccct gttcttcact gaacagtttt aacgcagagc ttgtctttgc 2485801 catctgcatc aaacttaata cgccttcctg cattctagca ccgcctgaag ccgtaaaaat 2485861 aataaacgga actttatcag cttttgcttt ttcaatcgca agcgtgattt tttcaccgac 2485921 gactgaaccc atgctgccca ttctgaatga agagtccatg acggcgacaa cagccgggtg 2485981 tccgccgatg gtgcccttgc ctgtcacaac agcctcgttt aaggatgttt tctcgcgatc 2486041 tttttcaagc ttttccagat atcccgggaa accaagcgga ttttccgaga gcattccctg 2486101 attaaattcc tcaaaggatt gttcatccat caagctttcg atacgctgtt ttgcgttcat 2486161 tgggaaatga taatcgcagt tcatgcatac ccgcatattt ttatccaact ctttagtgag 2486221 catgattttt ttacacttag gacattttgt cataatgcct tccggaacat cgtgcttcgc 2486281 ttgatcagac ggtacggaag catacttttt ctttttcgtg aatatatcct ttaacaaatg 2486341 attacctccc ttttgtgaag ggttctcttc accgcatgtc atcaaacaga tagacttgct 2486401 aataacttta ccgaaactat tgtacttttt ttgtcaaacg ctgtcatcct caattcgaca 2486461 actttttatt cgatgacgtg ctcggaaagg cttgtatgaa atcagataag gtgttgaaac 2486521 gacaaggttg acagcgcatt caaaaataat gttaaacccg gctgaaattt ttttaaggct 2486581 aaccccctaa aaaaatttca gccgtcagtt taacttgaga acagcgcgcc ggtctccgcc 2486641 aacgcgctgc catttttgga atgaattaaa attattcacc aataatcgta agttttcttg 2486701 ttttttctgc gacttcctca gggtcaacag tgattcttgc aacacctgtt tccatcgcag 2486761 cttttgccac agccttcgca acagcaggcg caacacgttt atcaaacggt gcagggatga 2486821 catagtctgc gctaagctca tcttctgaaa ccagtgaagc aatggcttca accgctgcga 2486881 ttttcatttc ctcgttaata tgagtggcac gcacatcaag cgctccgcgg aaaataccag 2486941 ggaatgcaag aacattgttt acttggttcg ggaagtcaga acggccagtt ccgacaacgc 2487001 ttgctccggc ttcacgcgca tcttccggca tgatttccgg atttggattt gccattgcaa 2487061 agataatcgg atcttttgcc atgctttgaa ccatttcttt tgttaacgcg cctgctacag 2487121 agacaccgat aaatacgtca gcatcaacga taacatcttt cagagaaccg tctttgcgat 2487181 cttggttcgt gaacttcgcc acttcatttt tgacatcgtt catgccgttc gggcgccctt 2487241 cataaatggc ccctttggaa tcgcacatca caatgtcgcg aacgccataa tgatgaagaa 2487301 gcttgataat cgcaatgcca gccgcacccg cgccgtttgc gacaacttta atggatgaca 2487361 tggattttcc agacagtttc agcgcgttca caagacctgc tacggttaca atggcagtac 2487421 cgtgctgatc atcatggaaa accgggatgt ttgtttcttt tttgaggcgc tcttcaatga 2487481 taaagcagtt tggcgctgca atatcttcaa ggttgacgcc gccaaatgtc ggttccagca 2487541 attttacagt ttcaacgatt ttatcaacat cgtttgtgtt taaagcaatc gggaacgcat 2487601 ctacgcccgc aaagcttttg aaaagaactg ctttcccttc cataacagga agcgccgctt 2487661 cagggccgat gtttccaagg ccaagcacag ctgtaccgtc agttacaact gctaccatgt 2487721 tccccttcat tgtataatca tatactttgt taatgtcttc atgaatatcc ttacacggtt 2487781 ctgcaacacc cggagaatac gcgaggctta aatctttcgc atttctgacc tctacttttg 2487841 atttagactc cagtttcccc tggttgactt tatgcaggtg taatgcttct tctcttaatg 2487901 acattctcct aaacactcct tatggatatt ttttgattcg tatactgctg cgttgattgc 2487961 tgcattctgc ggagtaaatc tatctgaata tttaaacagg atcacataat tgctccaatt 2488021 gtataacaaa aagcgaatcg ttaccactgt tttaaaacga cgtttttttg acccaacagc 2488081 tcttttaagc gatataacac ctggtgatct gcattgatat ggaacgactc aggtagctta 2488141 atcgtctgtt tttgcctttc ataatagaga taaacgcctg tttccccttt atgctccagc 2488201 aaaatgcgct taatctttgc caggatctcc tggctgtgct gactgctttc tatttttata 2488261 taaaccgatg gcgctttttc tgcatccata tcttctaata attctgcccg ggacatgatg 2488321 aattggatct tatcttgtct aacttcacat ttccccgcag tgaacaaaag agcgccttct 2488381 cttaaaacgg gagaaagctg tctgaattgt tcagggaaga ctacggcttc catctcgccg 2488441 gtttcatcac tgagcgttaa aaacgccatg ttttgacctg ttttcgtccg aatcgttttg 2488501 atcttcgaca gcagaacgcc tagtgaaagc tgccttttga ctgcccgctg agcctgcaga 2488561 atggagactg ctccttgcgc agtgagctgt tttcggaagg cggagagggg atgatttgaa 2488621 aaataaatgc caagcgtttc cttttcaaac gcaagtaaat ccaccagagg aagctcctcc 2488681 gtctccacat acttcggctt aattgaaaac gattcatcta aaaacaatcc catttggtca 2488741 tcgtccgcgg cgaatagctc agcatgttcc aaagcaacat caatggatgc gagcagcgtg 2488801 gcccggtttt ggccgaattc gtccatcgca ccagaaaaga taagtgcttc aagcattttg 2488861 cgatttacgc tttttgacgg cacgcgaaag cagaaatcga aaagatcttc aaatggtttc 2488921 tcttttcttg ctttatatat atctttgact gctgagacgc ctacactttt tatcgcgcgg 2488981 aggctgtatc tgacagatcc gttttcaact gtaaacggaa aactgctttt attcactgac 2489041 ggaggaagga tacgaatccc gctccccttt gcttcgtaaa gatattgaga gattttatcc 2489101 tcattgccaa tgacgcttgt cagcaatccg cacataaaat ataacggata atgagctttc 2489161 aaatacgcaa gctggcaccc gatcatgctg tatgccaccg catggcttct gttaaagcca 2489221 tagtttgcga atttgacgat taaatcgtag acctcatttg cagtgtctac agaatactcc 2489281 ttttttaagc acccttcaac aaaatggctt cgctctctgt ccaggatttc ttttttcttt 2489341 ttgctgaccg cccttctcaa taggtccgct tcgcctaaag aaaaccccgc catacgggaa 2489401 gcaatcatca taatttgttc ctgatacaca atgacgccat atgtatcttc caaaatgctc 2489461 cttaaatctt catgaggata gtgaacaggc gcccgaccgt gtttacggtc gataaataac 2489521 ggaatatttt ccatcggacc cggccggtac agtgcattga ccgccacaat atcttctagg 2489581 cccgaaggtt tcagccgttt caagacgctt ctcatccctg cagattcaag ctggaaaatg 2489641 cctgtcgtat ccccttttga cagcaaggag aacgttttgt catcgctgta ggaaatactt 2489701 gaaaggtcta ttttaatatt ttcttctttt tcaatcattg aagtgatgga ttcaataagt 2489761 gtcagattcc tcaaacctaa gaaatccatt tttaaaaggc ccaagtcttc aagatggtcc 2489821 atcgcgtatt gcgttaaata gatcccttca tgcccttctt gaagcggaac aacatctgtt 2489881 aacggttctt cactcaggac aacgcccgct gcgtgggttg atgcatgcct tggcagccct 2489941 tctattttcc gggcaattga atagacttgc tgaagcaggc ttgactcccg aagccgctta 2490001 tccagctgcg gtgactgctg tctcgcttca tccagcgtca ttcccggtct tgaaggaatg 2490061 agttttgcaa gctgatctgc ctccttcggg ctgacgccga atactctgcc gacgtcccgg 2490121 agcgccgcct ttgccgcaag tgttccaaag gtgataatct gtgcgacgtg cattgcaccg 2490181 tatttctgct gaacatattg aatgacttca tcccttctag tatcgggaaa gtcaatatca 2490241 atatccggca tgctgacgcg ttcgggattt aaaaatcttt caaacagaag gtgatgctta 2490301 atcgggtcaa catctgtgat atacagcaca tatgccacaa gagaacccgc cgcagaaccc 2490361 cttcccggtc ctgtaacaat ccctttttca tgggcgtgct tcataaaatc ccacacgatc 2490421 agaaagtaat cgctgaactt catccgcttg atgacatcaa gctcatattg aagacggcga 2490481 aggtatcgtt catcaggctt gccgaaacgg ctgcggagtc cctccataca gatatccgtt 2490541 aaataatcat cagcggacgt tccgtctggg gtcggaaaag acggtagacg ggtctgcccg 2490601 agactgacgt caacccggca ttgttccgcg atctctacag aagcttgcag tgcctcggga 2490661 tgctctcgat aaatgttttg catttcttcg agtggtttca aatcgagatc aggcaaatct 2490721 tcagcgggtg catccgtcag tttttccccc gctttaatcg ctttcaaaca acggtaggca 2490781 gccttatctt ccttccttat gtaatgcaca tcgcctgtgg ccgtaacagg gatacccgtt 2490841 tcttctgaca gctttagaat ctgctcagac aagacttgat tccctttaaa aggctgatag 2490901 gagaaataaa aagctccctt tccgaatata gactgaaatt ccagcgaggc ttgagcagcc 2490961 tgttcgaaca gccctccttc aagaagcgtt tcaatatatc ctttttcgcc gggcgttatt 2491021 gcgataatcc cttctcgata actgtgaagc catttcggct tcagtccgcc ttttgattta 2491081 gattgcagaa cgctgctgat tttcagcagg ttttgatagc ctgtattcga ttttgccagc 2491141 aggacgagcg ggtatgcttc aagctcgctg tcatctgtaa aaacagaagc cgtcaaaccg 2491201 attattgggt tgatccctct cgccttgcaa gctttataaa attgaatagc tccgtacatg 2491261 acatgatcat ctgtcagcgc caaagacgca tatccgagcc tgtcagcttc actgacgagt 2491321 tcttccacag ccgcggcgct gtttagcagg ctatacccgc tatgcacttg caggtgaaca 2491381 aaagacatgc tatcacctct ttctcattac gatccatttc ttccttcatt ataaggccgg 2491441 tttccaaaag aaacaaatgt tcttttttga ctcatcatca tacttgtcct gaaagctcaa 2491501 tatgatataa aaggtgaggt gataaagatg gatcaggaag caggatttat ggtgaatttt 2491561 atcaatagct acttcattgc gttaggggtg ctgatcgggg gcgcactcat cggagggctc 2491621 ggagcatact tggcaggcga acccccgctt acagccatta caaagcttgc caaccggtta 2491681 aaaatatggg cgcttgtcgc agctatcgga ggcacctttg atgcggtata cagctttgaa 2491741 cgcggcatac tcgaaggcaa tacgagagat atctttaaac agcttctttt aattatttcg 2491801 gccatggggg gcgcgcaaag cggctggctt attatatcat ggctgaccca ggagcatctt 2491861 tcttcatgag ggtcccccag cattacaaaa aaccgggatg gcagcgtttt ttcgcgggaa 2491921 tgatgtgcgg agccgtaatc agctggttct ttttcctgtt tacttacgga acattccaag 2491981 aggagcaggt cagcctcatc gaaaagcaaa aagagcatgt aaaagacttg aacaatcaaa 2492041 tttcgatcta tcaggaagac ctccataaac tgaatgaaga taataaaaga aaactgctga 2492101 ttcaaagcgt cagcgtcaaa ttgctgaatg gggataaata taaaatatca cagccggata 2492161 aaacgaaatt cgaggagcat gtaaaggatg atatttcaga ggtgattaca aaagacatag 2492221 agagcgtcta tcaaacaaag gatctcttga agcggacaat tgaaaataaa gtctatatga 2492281 tcaatgaaaa aaaatacgag gcaaccgtca gagaattgat tatttatacg aggctgacag 2492341 tggaacttga aatttctttc gccacataat tatggatttt ttttaaattc tccaaacttc 2492401 tgtcgctttt tcccattctt ttttataaac tatatgtgag gcttaatggc gaaaggaagg 2492461 aggaagggaa atggaggttt acagtgaccg tcagttagca aaagatcaag cagcccgtct 2492521 cagacaaggt ttttctgcat atgccgaaac aaactcactc gcttccctca tcaaaaaaga 2492581 acttcaatca cacaatctcc aagtctacga ggaccttact gatttcggct gctggttcat 2492641 ccccgtcaca gatgaacact aagagagagg gtctcccctc tactcgtgtt ctttacataa 2492701 tgtttccaga tcagctaaaa tacgatcagc ttcatcccag ctgtaaatag aggcgcctga 2492761 agctaacgga tgccctccgc cgttatattt ccgggcaagt ccgttaatga caggcccctt 2492821 cgaacggaat ctgactctga tttgatcgtc ttcttctacg aaaaacaccc aggcgcgaat 2492881 acctgagata ttgccaagcg tcccgacaag ctgcgacgct tcagaagccg ttgtgccgaa 2492941 tttttcaagc gtatcctttt tgatgaaaac agaagccgcc ccgttttcgg acaaagacac 2493001 attttgaaag ataaagccgt taagcttcac cacattcagt tttgtttcat acaattgatt 2493061 aaataactct gaggaagaga atggatactg aatgagctcg cctgcatatt ttagtgtttt 2493121 ttccgtggta ttcggaaata aaaagcgtcc ggtatctcca acaatgccgg cgtagatcag 2493181 ctctgccgct ttcgtattca gcttccagcc gtgctctttt ccttctaaat acagctcgta 2493241 aatcatttca cttactgagc tggcgcttgt atcgacccag agaaggtcac cgtatggatc 2493301 ttcgttcgga tggtggtcga ttttcattag tttggcgcct gaaggataac gctgatcgtc 2493361 gattctttcc tgatttgccg tatcgcagac aatgacaagt gcgccttcat atgtttcatt 2493421 gtccacctca tcaagggaat ataagaaaga gagggacggt tcaggcgtgc cgaccgcaaa 2493481 aatatttttt tcaggatatg tttcacgcag gatttccgta agcccacact gtgatccgta 2493541 ggcatccgga tcaggacgca catgtctatg taagataatc gtgtcatata atgatatggt 2493601 tctgatcaat tctgttttca tttgatactc ctttattgtt tttattcatt aaatcacatt 2493661 ctctgccgac ggaaaagaaa aataacgtca aaaccaagcc cgtttttgta taaaatgggg 2493721 ttgtaaactt ttacgatgga ggatttcatt tatgctggtt cttgtttttt tgattgggct 2493781 ttcagcctgc ttttatgtgt actataaagt aaaaggcgta cgggcaaagc catctttggc 2493841 aaaagaaata tgttcagcaa aatcaagcat ggccttaggg tcactagtcc tgttctacgg 2493901 gcttaaccaa atgatattat tccattcagt attaacgtta gtaatcggcg gtatctttat 2493961 cgtcatagga gcaggaagcg cttgggcagg ttataaagcc ttcaggcatt acaatcccct 2494021 tcacgccaaa gaagctgaaa gagatcacgc gtaaggggcg cctgaacgtc ccttagcttc 2494081 tttccatcag ctgaaccatc agcatcgctt tagacacgat atgaccttgg ctgtgcactt 2494141 ccacttccat tttcccaaac tttctgccgg cctccaagat gcgaggtttg acttcgatga 2494201 ctgattccat ctgcacaggc ttcaaaaaga agatggtgat gctctctatg acgagttcgc 2494261 cgcgtttttt cgagcgcaaa aatcggtttg ccgcttgcgt caaaatggtc gtaaatacgc 2494321 cataagaaat ggttccaagc tgatttgtca tttgcggcgt gacttcatac tcgtaaaccg 2494381 tttgatcttc tttatcatca ccctcatctt taaaccccct tgaaacgata tcatcaagct 2494441 tctccccgac ctgcggctgc ttttgaatca tttgaagagc tttcaatacg tcttggcggc 2494501 tgatcatgcc gatgagtttt tggtggccgt cagtgacggg aagcacttcg atcccttccc 2494561 ataccatcat ttgcgcagct gaagcgacag atgttttccc aataaccgtg acgggatttt 2494621 tggtcatgac tttttctata gatgcatttc ggtcatggcc agcaatatct tttgatgtca 2494681 gaatgccatg gattttcatt tgatcgtcga caaccgggaa gcggccgtgc cccgtttcaa 2494741 aatttttctc ataccatttt tcaagtttat ccttaggcga aagatatacc gtgcggtcag 2494801 caggtgttag gatgtcctcc accaaaacaa tttctttttt gatcagctgg tcatatattg 2494861 cccggttaat catcgcggca actgtaaagg tgtcatagct cgtggataaa atcggcagtt 2494921 caagctcatc tgccagctgc acaatgctgt catccgtgtt aaagcccccg gtcaccaata 2494981 cggccgcgcc cgcttcaagc gcctgcctgt gtgcattgat tctgtttccg acaatcaaaa 2495041 gattccccgc tgcggtgtaa cgcatcatcg cgtcaagctc catcgcgccg atgacgaatt 2495101 tattcaatgt cttatggagc cctgccctgc ctccgagcac ttgtccgtct ataacattta 2495161 caacctctgc ataggtaagc ttttcaatgt tctctttttt cttttgttca attctgattg 2495221 tgcccacacg ttcaatcgtg ctgacaaacc ctttattctc tgcttccttg atcgctctgt 2495281 acgcggttcc ttcgcttact ttcatttcct ttgcaattct tcggacagaa attttttcac 2495341 cgacaggcag tgaatcgata tacgttaaaa tttgttcatg cttcgttgcc aagcctttca 2495401 cctctaagga cagtcttctt gtttttatta taaggtttca aaggatttat acgcaatgag 2495461 gctggaaaat aaaaaagaag cccgaccggc ttcttacagc gttgatttcg ttccagtcaa 2495521 acgcaaggac cacgtgattc cttttacatc gtaaagcgga aaaaccttta tttttctttt 2495581 aaatggacat caaccgctgt cttaacaata tttcgattcc ctattttaga taaaacaaat 2495641 aaaactgcgg atagccatat cgcccctatg gccgtataga tcaatggatg aacagctgtg 2495701 tttgcgatcc attcatttat taatgttctg gcatttacca gaataataaa tcctcctaca 2495761 agcacaccca tcaattgcgg atgaaacttc tgcaccagcc atgctgcgat aggggcagcg 2495821 ataattccgc cggccattag tgaaaacacc cataaccaat tgacgtcctc ccatcctaat 2495881 gaaataagaa aaccggcggt tgcagatacg gcgatggcaa attcacttgt gtctacagtc 2495941 ccgacaactt tcctcgggct caagcctttg cgggataata aaatcggagt ggtcaccggt 2496001 ccccagccgc ctccgcctgt ggcatctgca aaaccagcga tcactcccaa tgggatggat 2496061 tgttttcggt ttaacggcac atgcttcttc tcaagagccg gcttatattg aaataaaaac 2496121 ctgatcaata catatccgcc cagaaggagc aaaaacaaag aaatataggg tttcgccaca 2496181 tctccaggta attggctgag gaatgccgcg cctaaaaaag cgcctataga gccgggaatg 2496241 acaagctgat aaacggtttg tttgtcaaca ttgccaaatt taatatgcga cactcccgat 2496301 gcggcagtcg ttacgacttc cgctaaatgg acagaagccg aagccacagc aggtgtgatg 2496361 ccaaacgcca ataacaaaga agttgaggta accccataag ccatacctaa cgaaccgtct 2496421 attaactgcg acaataaacc aataaatgca aaaacgatta atttcttcat cagaacaccc 2496481 catctatatc aatcagatat ttttgactct tcattcgaat ctaacaatct cttggcgctt 2496541 tcatataaaa aataagaggc tttgataatt gcagtttcat ctattgtaaa tgcagggtgg 2496601 tgccaatcat gatcaccgtc tgttccaaaa aacgcaaagg atcccggaat atgctcaaga 2496661 taataagcaa aatcttcccc cgcggttgat ggggcgggat caatgacttg aagtttcgct 2496721 ttatgtgcag cgtctcgcac cagccccgta attgcctcat cattacaaag cggcggcggt 2496781 ccggaatgcc acttcacatt tgcctttaac gagaaagcgg cagaaatctg ctctgtgact 2496841 gcaaaaaaac gctgtttcac ttgattacga acctctgaat caaatgtacg aacagtgccc 2496901 tcaatgacca ctgtatccgg aatgacattc caagtgctgc cgccgttgat tttccctacg 2496961 gttaaaatcg cgctttgcag cgggtttaca tttctgctta caatcgtttg cagggcgaca 2497021 ataagctgag aggcgccgat aattggatca aaaccattat gcggcaatgc tgcatgagca 2497081 cctttccctt ctatctctac tttaaatcgg tcaacagcag ccataagcgg gcctgttttt 2497141 aaccctacag tcccaaccgc gatatccggt ttattgtgaa ggccaataac cgcatcaatg 2497201 ccatccagtt ggccgtcctc tatcactttt gtagcgcctg cacccgcttc ctctgctggc 2497261 tgaaataata aacgaatctt tcctttcaga ctgtcttgat tttccttcaa taaaaaggcc 2497321 gcaccaagaa gcgctgccgt atgaaaatca tgaccgcacg catgcatgat ccctttatgt 2497381 ttagacgcat aaggcaatcc tgttttttct tcaattggca aggcgtcaat atcagccctc 2497441 aaagcaatcg ccggaccttc tgactcccct gctatgtctg cgaacacacc cgtttttaga 2497501 gcagtagggc gaatctgtat ccccttttct ttaaggcatt tttttataaa agcagttgtt 2497561 tcaaattctt cttttgacag ttcaggatat tggtgcaggt gccggcgaat gccgatgagc 2497621 tgcttttcta gcgttgagag atttacggga ttagactcct ctttcaacgt caggatgtca 2497681 tttcctgtag tctgatatgg ataggagcct tctatatttc tccaataatc caaagacata 2497741 tgttccgctc ctttccctat cccaatatat tttcttcaga ctcttcaaca taagatgaaa 2497801 taaatcggtt caatttatca gcaagaccgc ccgccccaaa tcttatatac ttgctggaaa 2497861 ctttcggatt atcttctttc aaaaagctta aaaaagataa aatataaatg cgcctgtaag 2497921 ctacttgtgt aattccgtac tcaaaaaacc agttatcaat gacattgtat acgcctcggt 2497981 tgacgccata taggttatta catttcttgt aaaagcagag atccggaaga tttaactcct 2498041 gatgggaaag aaggctttct tttttgtttg gtgccataat cccaatcagc tcaaagcgtt 2498101 ttgcaacgca cgaaatatcc tttttaattt gctttgttaa agactccaaa gaatcaaacc 2498161 ttctttcttc tctaatttta aagagaatgc tgcattcgat tttttctcca taaatgtctc 2498221 tatgaaagtc aaacaaaaaa atctccaatg tcttttcaag gttagagccc accgtcggtt 2498281 tcacaccgat attcataacc cctaaatgaa attgatgatt gactgtcgcc agaaccccat 2498341 aaactccatt acgcagccca tgtatttttg catctacatt tgccgtgggg aatccaagct 2498401 ttctgcctaa ttgttttcct ttcacaaccg taccggcaat gatcgtcaaa aaagtcagcc 2498461 tcctctctca gcttccgcat tcgatcagac gaaacctaat gatgtgatga atgtaaaacg 2498521 gattgatgct gcggaatgcc aagaccgaga ttttcccgca atgtcccgcc gcgataatct 2498581 tgacgataaa gccctctttc ttgaagaatc ggaatcacct tttctacaaa agcatcaagt 2498641 gttcccggta tatccgaccc aacgataaac ccatccgccg cctcagcgtt gaaccaagtt 2498701 tcaattaagg atgcgacacg ctctggtgtt ccgatgaata gagtccgtgg aaaagccatt 2498761 tcctgtgcta cctcccgcaa tgtcagattt ctggcttttg cttctctctt aatccggtct 2498821 gttgtgcttt gaaacgcatt ctttcccaca tcgccaatat cgggaaatgg ctcatccaac 2498881 gggtaaacac tcagatcata atcatcaaaa aaacgggcca aataagtaac agcattttca 2498941 atcggtatca attctgcaaa ttcacgatac ttcttttccg cctcttcttc cgtatctgcc 2499001 acaatcgggc tgatccctgg aaaaatccgc acacttgaag gatcacgccc ttcatcagca 2499061 gctcggcttt tcacatccgc ataaaacgct tttgtctctt ctaatgaatt ggaatgggta 2499121 aaaatcgcat ccgcattttt agcagcaaac tgccggcctg tttctgatga acccgcttga 2499181 aacactacag gctctccctg cttagagcgc ccgatattca agggcccctc tacttgaaaa 2499241 tactttcctt tatgattcag gcgatgaagc ttcgcctgat cgaaaaactg ccctgttttc 2499301 ttattgtgta taaatgcgtc atgctcccag gaattccaca gcccgcgcac aacatccaaa 2499361 tgctcttgtg cgatctcgta acgttcagtg tgttctggca aattagactt actatggttg 2499421 cgcgccgctc cttcctgcgg cgaagtaacc agattccagc cggccctgcc cccgctgata 2499481 tggtccagcg acatcaattg tctggagata gtgaatggct cagtaaaaga tgtagagaac 2499541 gtccctacta aaccaatatt tttggtaacc gatgccagcg cagataaaat ggtgatcggt 2499601 tcaaaacggt ttaaaaaatg aggaatcgat ttttcagaaa taaataagcc gtctgcaatg 2499661 aaaataaaac taaacaaacc tttttcagct gtttgcgcct ttttcatgta aaattcaata 2499721 ttcgtgctgg ccgagggatc aacatcggga tgacgccagc cgtcagttgt tcccccgaca 2499781 ccgtgaatca tggctccaaa ctgaataaaa tctgcacgtg tcatcttttt gcctccttta 2499841 tctgtgcatg attagcaagt gcaagatcaa ggtgttcaat gccgatttca gttatccctt 2499901 gatactgatt gccgcgcccg atttcgacca caggcacatg gcgcacccca tatttcacct 2499961 gtaaaatatc ccgaagcttt tctttctctg aaacatcgat attttggaac gggaaccctt 2500021 tttcattcaa ataattcttg acttcctcac aatacgaaca gcctttttta ctccaaacca 2500081 caatgttcac aacatcactc attcttctgt ccctccttaa cgttttgcag ctaaaactgc 2500141 atcgctcagc agctgataag acagctgttt ttctacagca tttttgatcg gtgtaaaaat 2500201 aacaaaatca ttgattttgt atgtgcctga taaacgtgtt aattcttctg ccacttcttc 2500261 ctttgttccg gcaataatcc cggttttttg cacgatgatg tcatagggct ctgtgacgtt 2500321 ttccagatag gcctcagcct gttcgcggga accgacgttg accttacgcc cgtctttcaa 2500381 aaccactttt atcgattcac gcgacacaat atgtttttcc gcttcttctt ttgtatgtgc 2500441 cgcaaaaaca gcgggggcaa gatgaaattc agcctcagat cctggcggga gatgcgcgtc 2500501 aaatgctcgg cgggcttcct tcagcacttc ctcttcaccg ttaataaagt aagcaaagac 2500561 aaaagagatt cccagttttg cagcagaaat ggcactctct gtgcttcctc ccaatagaaa 2500621 aatacccggc ttccgatcaa cctgcggcct aggacgcaat gcggcatagc ggtgggtatc 2500681 aggaaaatca tcccgaacga aatgagtaag ctcctccagt ttttcatcaa actgacgcac 2500741 cggtttttta tattcggcct gcagcgcgtc tgtggacagc tgaaacccgc cgggcgcttt 2500801 gcccactcca agatctatac ggccgggagc taacgctgat agaagatgga attgctccgc 2500861 tactttataa gagctgtaat gctgcagcat cactccgcct gatgctaaac gaatttttct 2500921 tgtgcttgca gcaagatagc ctaaaagaac ctcgggtgca gaccctgcaa tctcatcatt 2500981 gttgtgatgt tcggccaccc aaaatcggtg atatccacat tcttcagcca tttgtgccaa 2501041 tttcactgta tgctgtaatg tatcagctgc tgtctcccct tcaccaatca agctttggtc 2501101 taaaatactt aagcggatca tatcaccggc tcctttatgt gttcttttgg ttcaaataaa 2501161 tattccggcg aaacacggcg gagaaactgc ctcgttctgt cttttttggt atggcggaag 2501221 acttcctccg gggttccttg ttcaacaatg actccttcat ccataaaaac aacttgatca 2501281 gagacccttc ttgcaaactc catttcatgt gtaacaacaa tcatggtggc tccggttttc 2501341 acgatttcca gcattacctc aagcacttca ccgaccagct ccgggtcaag cgctgccgtc 2501401 ggctcatcga acagcagcac atcaggatga atggcaagcg cccttgctat ccctaccctc 2501461 tgcttttgtc ctcccgataa ctgactcgga taagcgttca atttatcttg aagcccgacc 2501521 tttctcagtt cattttccgc tacggcatac gcgtcttgtt ttctcatttt ccgggcaatc 2501581 gtcaagccct ccatgacatt ttcaatcacc gttttgtgag caaacaggtg gtattgctga 2501641 aataccattg ccgtctgttt tctgagccag tgaacctctt ttttggacgg aaagcggcaa 2501701 ttaatcactt tgtcatgtat agaaatgatc ccttcgtctg gacgttctaa taaattcagg 2501761 caccgtaaaa aggtggtttt ccctgatccg ctcggcccga taatcgtcac aacttctccc 2501821 ttgcgtaccg tgagatttat cccttttaat acatggtgga tgccaaactg tttatggata 2501881 tttttaatct caatcataaa gtgcctcctt gaaatctggc tgcctttctc tctaatactc 2501941 catttgcgga ttctaggatt agagtcagca cccaatagat aatcgctgct ccgataaacg 2502001 cttctaaaaa tgcataatta tcagaagcaa cgatagtcgc cgtccctgta atctctggga 2502061 cagccactat agccgcgata gaggtggtat gcaaaaagcc gatacccaaa tttgtgaagt 2502121 ttgggatgga aaccttcagc gcctgcggca atattacacg ccgaaaggtt tggctgtatg 2502181 tcaagccgat tgaataagcc gcttcgacct gtccggtatc catcgccaga atgcccgacc 2502241 ggatgatttc tgtgagataa gctccggcag ttaaagacaa ggccatgatg acaaacatgg 2502301 agaccggtat ctcattagcg gaccagccga gatgaaaaaa actgctgact tgatctgcaa 2502361 caggcggtat ccctaaataa atcaacataa tgtgaagaat tgcaggtgta cttcgaaaga 2502421 aagacacata aaaccttgag caagccacca agcccttaat tctaaaaatt ctaacaatta 2502481 tatttccaag agccacgaga aatccaaaca caatcggcaa aacagccatc atcaatgtca 2502541 gaggaatggt ctttaccatt tctttcatgg cggaaacgat aaatggaaag tcaaattgca 2502601 atcttctccc ccctcatccg aagaaatata tcaatgtatg ttcatgtcaa aaacagtaac 2502661 aatccttgtt tgattcttct tgattcgttt ttctgccact cgaaagaacc attcgaataa 2502721 aaccgctaca gcataataaa caatcgatag cgcaatgtaa acttcaagag aatggttgct 2502781 tgaggtaatc agtgtttggc cccttccgga catatccata acacctattg aaaaggctag 2502841 agacgtatct tttaaagaac tgatcaccat gtttcccata ttcggaaacg cctggacaag 2502901 tgcctggggc agaacgattc gcctgaaggc ctgactaccg cttaagccaa tactgtacgc 2502961 cgcttccgtt tggcctttat ctacactgcc cacccccgct cgaatgattt ctgcggctgc 2503021 cgctgcattg cttaacgcgt aggttgcgac agcagcataa aacgggtcca tttttgatgt 2503081 atcaatcccg ataagccccg taagcgccgg gatcccgtaa aacacgatga aaagctgcac 2503141 catgataggc gttcccctga aaaacgagat atacactttt gccaattgat ttacaattgg 2503201 aatattatag atgcggggca gtgccagaaa gagtcctaat acaaaaccga aaagcaagga 2503261 cagtgttaaa atgtataatg taaccggtaa ataagcggtt aacgtcggca caaaatctcc 2503321 aatcatgttc atatcaaacg ctttttccat cactgctccc tctcttttta cctaatactg 2503381 ctctttggaa tagtcgtcac caagccattt caaactgagc cttttcaacg ttccgtcatc 2503441 aatgatttcc tgtaaggctt tatcaatatc gtcacttaac gtttgttcat ttttgttaaa 2503501 cataaaatac actttggcat ttgaaagcac attaccgacg gttttttctt taatagtgct 2503561 cgtcttgttt tgaaagtcta ctgcaaaagg cgttgagatc gttgcgtccg cacgccccga 2503621 tttcagctga ttcgcagtct catttgcgcc ttggccctca taggcaatct caaacggccg 2503681 tccattatcc tcattccatt ttttcagtac aagcgctccg ttggaggttg cactcgtaat 2503741 cacccgtttt ccttttaagt cttcaattcc acggatcgta tcgttatttt gaagcacagt 2503801 aatttttaaa ggaaaatggt tgtaagcaac cttgttaaac agaaattttt tctcacgctc 2503861 tttgcttttc tccatttgat gtgccacgat atcgacttta tgctgtccga ggctgacaag 2503921 caggttggaa aattccatcg ttttaaatgt gaatttataa tgtggcaggc gcttatcaag 2503981 ctctttgatc agttcgacat cataaccggt taaatcgcct ttttcatcga taaagcaaat 2504041 attcggaaat tgggttccag ttccgaccgt gatcgtctgt accttctttt gcccggctcc 2504101 cgtcgtttga ctgcctgcac cgcaagctga cagaactgtt ataagcgaaa ataatattgc 2504161 catgaatgct gttttcgttt tcatctcatc gccccattta tttttcaaaa cttgattttg 2504221 aataatctgc cccgagccat tttcggctta gtttttttag cgttccgttt ttctccagct 2504281 ttttaatcgc ttgatccgtg tcatccgcca aggtttggct gcctttatta aacataaagt 2504341 acacctcggt atctaataac acgtcaccga ctgtcttttg gcggaaggcg tgcgttttat 2504401 tctgaaaatc gacggcaaac ggtgtagcta tcgttgcatc tgcgcgcccg gtttcaattt 2504461 gattggcggt atcattgctt ccctgtcccg catatttcaa atgaattggg ctgccgtgcg 2504521 ttttgttgta ctttgtaata taatctgccg catttgacgt ggcgccaact atgactgttt 2504581 ttccgtgtaa gtcttttaat gtatgaatct tgtgattatc ctctttcacc gtgatgtaca 2504641 tcggcgagta gttatatggg actttatgat acaaaaaacg cttttctcgt tctttatttt 2504701 tggccatatt gtgcgcaatc acatcaattt ttttatttcc gagactcgtc agcaaatttg 2504761 agaaatccat cgttttaaat tcaaatgtat attgaggcaa ctccttatcg atggctttca 2504821 tcacttcaat gtcatacccg gtcaattcac ctttttcatt taaaaacgca atattcggaa 2504881 aatctgttcc agtgccgact atgaccgttt gagcctgacg atctgttttg ttatttgttt 2504941 gcgaacatcc cccgccaagt aatgcaaaca ctgacagcag caaaaccaat cctttacgct 2505001 tattcatagg ctgcctcaca tcatgcccag ctgggcgcac ctaaaagcgt tgggttaaat 2505061 cgttccggaa tcagaacctt gtgcatcatc acacctatgt ccccgtcttt ttcctgctca 2505121 aaatacactt cataccctct ccttctgtac atgtcagcaa gccaaggatg cttgcgcgcc 2505181 gatgtgccga gtgtcagcgc aggagccttc agcatatctc gaagcacttt ttcttcaaca 2505241 tacgtaagca gcttacttcc ggcgccttgc cctttatatt ccggcagtgt cgcaaaccac 2505301 cacacaaatg gatattttga aggaggcgtc tcactctccc acgggaacct gattgtaatc 2505361 gttgaaatca gcttcccatc ccgctccagc acaatcgctg aatgatgttc aatattttct 2505421 gataccattt ggatatcagc tctcgtggat ggccaatcaa tatccagctg ccgaatgggc 2505481 tgaaatgcgc tgttaaccag tttcaacagc tccgatgcat cttcaacagt tgccagtcga 2505541 aaaatatcat cactcatttt tgtcactcct cttcacaaaa tatataattc ctatttgttt 2505601 actaagcttt tattgtttat actataaagc atactctgat ctttgactaa tcaaaaaaag 2505661 taaaccttca cttcagtaat tttaatgatg aaaaacagga gggagcacat tggagttacg 2505721 ctcaatcaaa acgtttcata cgattgtaaa atttggaagc ttctataaag ctgcagaaat 2505781 actcaactac tcgcagccga cgatatcgat gcgtatgaag caattggagc aggatttagg 2505841 cgtactgctg tttgaaagag gaaaaagcct gcagttgaca aaagcaggga agctttttta 2505901 tgaacgaaca ggagatcttt tgatgcaata cgaggcgctt aaacacaacc tctccgactt 2505961 aaaggaagaa gaggcaggca ttatcaacat aggggtttca gagccaaccg ccagtctgat 2506021 attccccgag attttaaagg atttcttaat ggattaccca aagataacgg ttaatatcaa 2506081 ggttgatgac gccaatacct gcagtcaaaa gctcttagac gggacgattg attttgcagt 2506141 ctgcggcgag ccggagctga ttcttgaaaa ttactaccat ccattttttt atgacacatt 2506201 aaatgtgatt gtatctgatc aacatccgct cgctgagaag aaggctgtcc atttgtctga 2506261 tttagcagaa gagcgcttca tatttacgcc cgccaattgc cccattcgct tacaaattga 2506321 acagcattta catagagaac tcgggaatcg ctacaaaaaa atggagctca caagcagcat 2506381 gtcacatgaa tattacgtac gtgaaaacat cggaatttca atctttacca gcaccgcaca 2506441 ttctaaaccg ttcaacggca ctaaagtcat tccaattctg aacctggata tcaccccgcc 2506501 catagggctg ttgacaaatc aaaaagaagt tcattttgac cgcgccacga aggacttgat 2506561 cgcccggata accaaacgtt ttcagcagcg cagcaaagaa ttggaaggaa cctctgataa 2506621 gaccattaca ggataactga aaaaataaaa accacctcct gattcatcag gagatggttt 2506681 cacggtttaa agctcgatcg tctcaccgac cgacatgact ttgccgactc cgcccggcag 2506741 gctgtcagcg aatgcttctg ggtcttgttc gatgaccggg aatgtattgt aatgcaccgg 2506801 cacgacctgt tttgcgcgca gccattcagc agcaagcttg gcgtcttcag gccccattgt 2506861 aaagttatcg ccaatcggaa ggaaagcaag gtcgatatga ttcaattcgc caatgagttt 2506921 catatcagag aaaagtgccg tatcgcccgc gtggaaaatc gttttatctt ctacagtcag 2506981 caaaataccg gcaggcatgc ctgtgtaagt gatcgttttg ttttcttcat ctgtgatggc 2507041 tgatccatga aaggcctgtg tgagcttcac ttttccaaaa tcgaactggc gggagccgcc 2507101 aatatgcatt ggatgaacat tcaagccttt ccagcctaag tacacagcga gctcgttcgg 2507161 ggctataacc agcgcgttat tttgcttggc gatttgttca gtatcaccga catggtcatt 2507221 gtggccgtgc gttagtaaga tgacatccgc ttttacatcc tccggcttta tatccgttaa 2507281 tgaattccct gttaaaaacg gatcaaaaat aatatgatgg tccttcgttt ccactgtgat 2507341 tacagaatgt ccgtgatatg tcactttcat ttctttcacc tcgtcacatg attttgtttt 2507401 ttttattttc cctttttaaa aagctgaaaa acttatgttg tttgattctt gttaatgaca 2507461 ttgaggcctc cggtggcttc aatgacagtc cctgtcacaa ggtctgagtt ctcctcacac 2507521 aagaaagcga taatcctggc aatatcctcg cctgtaccgg atcttcctat cggcgttttt 2507581 tctttgccga ttcgcattct ggcttcctct atcgatgctt ctttcatgtc gccgacaatg 2507641 tctcctgggc aaaccatgtt ggcggttatg ccgaattcgg cttcttcaat ggcaattgtc 2507701 ttcgtcaaag aagccaagcc cactttcgca gcgccaaatg ccgatcggtg aagccagccg 2507761 ggcgcgtgag ccgcaccttg gaatccgtac gtaataatgc gtccaaattg ctgttttctc 2507821 ataataggaa taaccgcttt gaataaatga aagacggcgc ttaaatttcc ttccagcatg 2507881 ccataccatt catcatcagt ataatcggct aactttttac gttcaaatat gtatggtcca 2507941 gcgttgttaa tcaaaaagtc gatccttccg aagcggttta aggcagcctc tgcaatacgc 2508001 agcagatctt cttttttggt gacatcacct tttacaaatt gcagccggtc aagacaatcg 2508061 ggacaggctt ccttcaggcg gctgactgcc tcctcatcct gtctgtaatt gactgttact 2508121 gaatacccct ttgcaagcaa cgtttcagtc actttgcggc ctaaaccctt cgaaccggca 2508181 gtaattaaag catgtcgcac atgaatacct cccaaagcaa cgtcgccgct ttcaataaag 2508241 tgtttcttct tctactttac tataaaaggc ttgcaatatc actttttaca ctttggcata 2508301 caaaaaaagc tgcctgtaca gacagcttat tctgcaggag atgaagactc ctgatcaggc 2508361 atatcgacat aaccgctttg atatgcttct gaaatgagcc ttgttgtctc ctggctttct 2508421 tgttcatcat aaatatagcg ttccggttct tttttcatca ttctgcctcc catcattata 2508481 gaggtaggtt ggctataatg acgggatttt atgaaggaaa ttttaacaaa ctcctgctgc 2508541 cacgcaagct ttcgcttttt caagcgcctg ttccacctgt ttgaatccgg tgcccccggc 2508601 gctcattctt ttttcaactg cgtagtaagg gtctaacaca gtgtaaatat cttcttcaaa 2508661 tagtgtgctc gcctgctgaa actcgccaaa cggcatatcg cttaaataga tccctctttc 2508721 gatgcatgtg tacacaagtt tcccgaccac ttcatgcgct tctctgaacg gcattccttt 2508781 tttagctaaa taatcggcca gttccgtcgc gtttgaaaag tcttgttttg ttgcttgctt 2508841 catgacgtct ttgtttacag tcattgtttg gatcatgcct gtgaagattt gcaggctgcc 2508901 ctccaccgtt ttcaccgtgt caaacatgcc ctctttgtct tcctgcagat ctttgttgta 2508961 agcgagcgga agtcctttca tgatcgtaaa cagccccatc atatcgccgt atacgcgtcc 2509021 tgttttgccg cggatcagct ccgccatatc agggtttttc ttttgcggca tcatgctgct 2509081 tcctgttgcg tacgtatcgt caagctcgat gaatttaaac tcctgcgagc accataaaat 2509141 gatttcttca gagaaacggg ataggtgcat catcagcata ctgctgttgc ttaaaaactc 2509201 caaaatgaag tctctgtcgc tgacgccgtc caagctgttt tcataaatgg catcaaagcc 2509261 gagcagttcc gctgaataat cacggtcaat tgggaaggtt gttcccgcga gcgccccgca 2509321 gccgagcgga gatttgttaa tccgcttcat tgaatcctga aaacgctcct tgtcgcgctc 2509381 aagcatccag aaatacgcaa gcagatggtg agcgaatgaa atcggctggg cgcgctgcaa 2509441 atgtgtgtag cccggcagaa tcgtttcaac gttcgcttcc gccttttcaa tcagcgcact 2509501 ttggaatgcc tcaatcagct cgatgatgtg gccgacatga ttcttcaagt ataaatgcat 2509561 gtcagtcgcc acctggtcat tccggcttct gccggtatgc agcttgccgc caagaggacc 2509621 gatttcgtca atgagcattt tctcaatgtt caaatgaata tcctcataat cgactgagaa 2509681 ttccaatgct ccctcctctg ctttttgcaa aagggtattc aggccctctc ggattttcaa 2509741 ctcttcttct gctgtcagaa taccgcattt tttcagcatg gcagcatgtg cgagagaccc 2509801 tgtaatgtct tcagcaacta aattttggtc aaatgatatg gacgcgccga actcgtcgac 2509861 ccatttttcc ggtgtttttt gaaatcggcc tccccaaagc ttcttcatgc tttaatctgc 2509921 tccttctttt tcacgatgct gttcactttt gtcggaagtc cccaaagctc gataaatccg 2509981 attgctgcat ggtgatcaaa tgcatcgtct tttgtatatg ttgcaagttt ttcatcatat 2510041 agagagtatt ccgatttacg tccttctaca attgcatggc ctttaaacag cttcacgcgg 2510101 acaatgcctg tgacatgctt ttgcgtttct tttaagaaag cgtgcagcgc gtcttttaac 2510161 ggtgagaacc ataagccgtt gtaaatgatt tctgacattt tttgctcgat gatcggttta 2510221 aagtgggcta cctctttcac cagtgtcaaa tcttctaatt ctttatgcgc tttgatcagt 2510281 gtcatcgcac cagggcattc gtatacttcc cgggatttaa tgccgacgag gcggttttcc 2510341 acgtggtcga tacgtccgac accgtgcgcg cccgccattt cattcagctt caagatcagc 2510401 tcagaaagcg agtaggaaac accgtcaatg gagacaggca cgccctgttc aaatgcaatt 2510461 tcaatcactt ccggcgtgtc cggcgttttt tccagcggag ctgttaaatc gtatgcacct 2510521 tctggcggcg ccgcccatgg atcttctaaa atgccgcact cattggcgcg tccccagagg 2510581 ttttggtcga tagaatacgg gctgtcaaga ttgatcggaa tcggaatgcc gcggctagcc 2510641 gcatattcaa tttcttcttc acgtgaccac tgccattcgc gaaccggcgc gatgacttct 2510701 aggtcagggt ttaatgattt aatggagact tcgaaacgaa cctggtcatt tcctttccct 2510761 gtgcatccgt gggcaatcgc ctgtgcatct tctttttccg caatttcaac cagttttttc 2510821 gcgatcagcg gtcgagataa tgccgaaaca agcgggtatt ttccttcata cattgtgtgg 2510881 gcctgcaaag agataagcgc gtaatcctgt gcaaattctt cttttgcatc gatcacgtag 2510941 gagtttgtcg cgccgacttc aagcgctttc tgctgaacaa atgccaaatc tttgccctca 2511001 ccgacatcca ggcagcaggc gattacatta tatccttgct cctgaagcca ttttattgcg 2511061 acggaagtat caagacctcc tgagtatgct aatacgactt ttttctgttc tgacatgata 2511121 aaaatcccct ctcaaccgtg tttctatttt gtataaaaat aaattatatt taataaaaat 2511181 acattttgta tgtatacact ttaacaagta cgtttcgttt tttcaagcct tttataaaaa 2511241 aaacttcacc taaatttcag gtgaagtttc atagtattta ttcatttact tgtcttttct 2511301 gatttctctg accacatgcg caagttcggg aataatcagc ttattcattg ccagctttac 2511361 tgcgccgctt gagcctggcg ttgagaaaac agcggtatgc tgaatgacgc cggcagttgc 2511421 tctcgacatg attgcggcag agccgatatc ctctgtataa ctcagcatcc tgaatatttc 2511481 tccaaagccg ggcagttctt tcgaaaacag cggcgttatg gcttcaattg tgacatcccg 2511541 atctgctatg cctgtccctc cgtttaagag taccgcgtct gtctgttcat ccatgcagcc 2511601 cgcaagcact gaccgttgca aagcatcctt ttcgtctttt acaatttcat atgcggcaat 2511661 atgatgaccg gcttcttcta aaaatgagat catcagcttg ccgcttttat cggtttcatc 2511721 tgtcctcgtg tcactgacag taatcacttt gcaccgaacg atatcgggag cttcttgttt 2511781 atgctcttga acgctcattg gcccacctct tttatgtttt ctgtctgtca ctatcatgca 2511841 tcaacaaaaa agcacattca agagaatgtg ctttcatgcg atttattttg ctaaacgaac 2511901 aacgtcgcgc gcaatcatga cttcttcatc agtcgggatg atcatgactt ttactggaga 2511961 atgcggatag ctgatgaaag cttcctcgcc gcgcacgtta ttaagcgcag ggtcccagta 2512021 tacgcccatg aattctaaac cgcgaagaac gcgttctctg acttccacac tgttttcacc 2512081 gataccggca gtaaagatga tcgcatctac accgctcatt cttgcagcgt aagaaccgat 2512141 gtatttgtgg attctgcttg cgaatacttc aagagccgtt tccgcgcgct catttccttc 2512201 tttcgtagct tcaacgatgt cacgaagatc gcttgagaaa ccggaaatgc cgagcagtcc 2512261 gctttttttg tttaatgtat tcagtacttc gtcagccgtt tggcctgttt tctccatgat 2512321 gtatgggatc agggcagggt cgatgtttcc agagcgtgtg cccattgcta caccggcaag 2512381 cggcgtaaag cccatggatg tgtcaataga ttttccgcct tcaacagcgg caatacttgc 2512441 tccgtttcca aggtggcagg aaatcaggcg caagtctttt aacggacggc cgagaagctc 2512501 tgccgcacgc tcagttacat atttatgtga agtgccgtgg aagccgtatt tacggatgcc 2512561 gaatttttca tagtattcat acggcaagct gtaaaggtaa gactgctcag gcattgtttg 2512621 gtggaatgct gtatcaaata cagctaccgc aggaacattt ggaagcactt ctttgaacgc 2512681 tttaattcca acgatatttg ccggattgtg aagcggtgcc aattcagaaa tatcttcgat 2512741 ttccttaatg gtttcatccg ttaataaaac agaatcgctg aatttttctc cgccgtgaac 2512801 gacacgatgg ccaattccgt caatttcatt caagtcttta ataatgccga attccgttaa 2512861 cttattcagc agcattttaa cagctaccgc atgatctgga atatcagtta cttctgtatt 2512921 tttttcgccg ttcacagaaa ttgtgaatac gctgtcggcg ataccgattc gttcaactaa 2512981 acccttcgtt aaaacggttt ctgaaggcat ttcgaaaagc tgaaatttca aagacgagct 2513041 tcctgcgtta attgcaataa ttttggacat gattgacgct cctttatact ctgtatcaac 2513101 aacttcgttt ttcgtacttt tttcccggtg aatatcaaca tcttctccga aaaatatctg 2513161 acttttccat ttaaacattg tcatgtcggc ttttcaagtc aacttgcgta ttgataacgc 2513221 ttacaataag aagtcgttat tttcagacac attcactata ggttttgtat tgatgaacgc 2513281 ttacaatttg cggtttttcc ctctgtattt tgtgtttcaa agctggattc aattcgtcaa 2513341 gtccggtctt caaaagcata aataaaagca gcttaggcat cgacctcata cggctgtcta 2513401 agctgctttt aaaacactta cttttctttt ttaaaccatt catcaaattg agccatcata 2513461 tcaagcatcg ccttttgatt ggagaaagac ggaagattcg caagcagaat ttgccccggc 2513521 gctttcgtat tctctccttg tttctgaagc acaaggatgc ttttggcatg agcttcgtct 2513581 ttaaaaatag attttggcag ctgcaacagt gcgttgatat gaaccttatc tttgaaaaac 2513641 tgtttcagct tgccgctttg ggagctctca aacaaatgat tcggaatcat aaaaaataag 2513701 tagccgcccg gtttggtatg cttgacgctc tgttcaataa acagatgatg agcgaaggaa 2513761 tggccttcgt cagctttgag ctcaaacgct tctgctcctt cgtcattcgg ataatagccg 2513821 actggcagat cacaaatgac cgtgtcaact ggatcgataa acaacggctc aaggctgtcc 2513881 tggtggaaaa gctcaagctc ttttttcaga aggttcgctt gggcataggc gatcttcaag 2513941 agcacatcat caatttcaat gccaaagctg tttgccgttt tttcagacag ctggttcagc 2514001 acggtaaaca gaaggttccc agttcccagg gctggatcaa gaatggtcag ttcctttttg 2514061 tccgccataa atttattcac caaatagctg atgaaaagcc cgatcgtatc cggcgtcatt 2514121 tgtctgtttg gatgcgagat atctttcatt cctttaagga cggcaagctg aaaagccttg 2514181 cgtacccact catgctcata cgtgccgaat tccgcttttt caagcagagc ctgaagttgt 2514241 ttggttttct gatcagcagg cagtttcagc tgatccgttt tttcaagaaa atacatttct 2514301 cctgcttcgg ccagcgcctc tatatatgaa atctgcaatt cattctttat cataatcgcg 2514361 gcttcgttta acagctcata caccgcacct acatggtctt tttgcatatt gtgttcctcc 2514421 ttgccatgaa aaaagctccg gcggcagcct ggagcttttt tccctgctta ctttactaat 2514481 gccttagcag cctcaattgg cttttcatag ttcgggtggt ttgttgcttc gcttacatat 2514541 tcagcgtaaa cgacttttcc gttctcatca aggacaaata cggaacgcgc aagcagacga 2514601 agttctttaa tatacacacc gaacgcttcg ccaaatgaca tatctctgtg gtcagacagt 2514661 gtttccactt tgtcaattcc gttagcgccg caccagcgcg cttgcgcgaa tggaaggtct 2514721 gcactgattg tgtagacgtt gacatctcca agctttgcag cttcttcgtt aaaacggcgt 2514781 gtttgtgcat cacaaacacc tgtatcaatt gaagggataa cagaaataat cgttaccttt 2514841 cctttcatgt cagctaacga tttttcttca aggctgttag tcagcactgt gaaatcagga 2514901 gcttgatctc ctaccttcac ttcttgtccg acaagtgtaa ccggaccgcc tttgaatgta 2514961 atttcagcca ttataattcc tcccttttgt atgtatgtct ctatcatagt aaagtttcct 2515021 gcaaactgca aagtttatgc caaaaaaaag ttaactgcgg ccagcgcagt taaccttttt 2515081 ttaataattc atattgttca tttggttttg attttggcct tggctttggt ttttgttatt 2515141 tttcttgaac atttgctgga tgcgctcgag tgtttgaggg gctgcgtcta aaattttctc 2515201 tattaaatgg gtattttcat ctaaatgaag cattctgatg cctgtcgatc cgacaattaa 2515261 aaacgcgatc ggcgtaatgg acacaccgcc cccgcttccg cctccgaaag gaagtttctg 2515321 ttctcttgtc tcatcgtctt ccgatttctt ttcggccggc tttccgccaa actcgcttcc 2515381 gcctgcggcg aatccgaatc caactttaga aacagttaaa atcacacttc catcaggcgt 2515441 ttccactgga tctccgatga tggtgttaac atcaatcatt tccttcaagt tttccattgc 2515501 ggttttcatt aaaccttgga tgggatggtc tgccatatac gcttcctcct taaactgatg 2515561 aatcattctt tgaagtcatt ctagccgacg gattcttctt taatacggat agctcccgtc 2515621 cgtatttgac gaatttgaaa gctgcaagca tagcatgtcc aaagcgaaaa aagaatatac 2515681 actgaaaatg ggtcttggaa acagggactt gaaacgacgg gatcacctca tagacaggtt 2515741 tattcacaaa gtccaggtgg tcgtagagca ttgctgcgat accgcccttc acgccccata 2515801 cagcaccggt taacacacct gtcactgccg cgtcctgaat tccgattact gtaacccatt 2515861 ctagttttgt gatatgtaaa tgcgcgagaa aagacgcgct gattttccgc agtctggtga 2515921 cctgatgcaa aagcatttcg attttattaa tgctttgctg cacatcgttt tgtgtaattt 2515981 ttttctttcc gctgcttttt ttcattttgg attcagtttt ttgtttgata tccactgttc 2516041 cgtcttcttt gttcacctta atcgccggga ttgttttttt gatccttata aggccaaaca 2516101 gcgccgtaat cttcaaggtc aatttgtcat tatcatcggc atgaagatac tccagcgcga 2516161 catggatttt cattctgaga agcagtacga tccctatgag aataagaatg gctgtcagta 2516221 catacaccat attcttcact tcctctagga gcattatcgc caattcctaa aaaaataaac 2516281 ccggacggaa gtccgggtta tcggttattt gcggtataat ttttcatgca ccacggtggt 2516341 atccgcgatg taatcatgaa tcccttgttt tgtaggtgaa aaggcaacaa cgatatataa 2516401 aatccaaatc ttatcaatat accgtccaac cacttcacga aaaatcactg tactccatgt 2516461 cagcttgcta tcttgcttca cagaaaccac tttgaggccg aacaccattt taccaagcgt 2516521 ctgcctgaag tattttgtca tgagtgcgaa ataggcaaga tacacaataa gcgttgtcac 2516581 actgtaggcc gagaaggtaa acatgccgga tgttttcggc agatccaata cggtaaagag 2516641 gggagaaacg agcaaatggt ttaatcccca tatcacgagc caatcaagca ggaaagccca 2516701 gaaacgaacc caaaagccag cataggcatg tgtcagcagc tccgcttctt gcgggccttt 2516761 gatgtcattg cgctctaact cttcatatgt cgcgtccatt attgttccct cctacttcgc 2516821 atagagatac atcattctcg gcgaaccgga ttgcgataga atttctctca tattcaaaaa 2516881 atcaatttca cttttaaaca ttttgttcgc gcccatggaa aacagtgagc ctaatccgaa 2516941 gctttcctca taagaaatga cagaggcgtt tttcaaatcc ttgtgatcct ttttcatggc 2517001 cgtaatggta tcgtcataaa aaccaagctc atcaacgagg ttcagttttt tcgcctgccg 2517061 tccgtcatac acgcggccgt ccgcaatttt ctttacctct gctttcggca tgccgcgccc 2517121 ttttgaaatg acatcaacaa agccttcata cgaattatca accatcgatt gcatgatgtt 2517181 tttttcttct ttcgtcatct cacgggaagg agacataatg tccttatggg ccccgctctt 2517241 aatcgtttca aaagaaatgc caagcttgtc ggcaagcttt gaataattga cgctttccat 2517301 aatgacgccg agtgacccgg tcagggtttc cggtgtcgca aaaatcttat cagccgctgt 2517361 tgagatgtaa tagcctcctg atgctgccat cgaacccatt gacacgtaaa tcggtttttt 2517421 cgtttctttc ttgatttctt ccagtttctt atgtatttca gcactttcat acactccgcc 2517481 acccggagaa ttcaccttca gaacgatacc tttgaccgtc ttgtcatctt ttgcgcgctc 2517541 aaggtttttt aagaacgttc tgtggttata tccgtctgca ccaagcagac tgcttgagtc 2517601 cccattatcc tgaatggtgc cgctgacctc taatacggca attttacttg agggactgcc 2517661 gttttccagc gtcttctcct gcgattcatc cgtcagtgat gtgagatccg tttgagcgcc 2517721 tttgacgctt tcaaagaaac tcatagagat gctgacgata atagacacgc cgaaaatccc 2517781 cagagcaatc actaatgcaa tccatctttt tgcattcatt ttttctcctc ctttttccta 2517841 aactctctca ttatacgatt caatatgaaa aatgtttcac ttcatgagaa agctccggct 2517901 taacgggctg ccggcaaacg tggtacactt atggccaaag gtattttatc acaaatactg 2517961 gatggcagaa aaacttaaat atgacagcaa aggggaaatg ggatatgacc gatcaacgcc 2518021 gtaatgttta tttttttcac aaacaggatc aggaaacgaa cgaacaagcc cgctcgttaa 2518081 cacaattagc ggaagagcat ggatttaccg ttgtgaacca gcactcagac gccaatatta 2518141 tcgctagcat tggcggggac ggcacatttt tgcaggcagt cagaaagacg aattttcgtg 2518201 acgactgctt gtacgtcggc attaccaaaa aggggaaagc tcatttatat tgcgactttc 2518261 atagtgatga gcgagaaaaa atggtcgatg caatgacgtt tgaacaaatt gaagtgagaa 2518321 aatacccgct gattgaagtg acagtggatc aagccagtcc ttttcactgc ttaaacgagg 2518381 tatccatccg ctcaagcatc atcaaaacct ttgtgatgga cgtgctgatt gacgatctgc 2518441 actttgaaac gtttagaggt gacggaatga ttatctcaac gcctacaggg agcaccgcct 2518501 ataacaagtc tgttgcagga gctgttgttg atccattgct tccatgcatg caggtatcag 2518561 agcttgcatc ccttaacaat aatacctacc ggacactcgg ctcgccattt gtcctcagct 2518621 ctgaccgaaa gctgaccctt cgtgtggtgc aggacggcaa cgaacaccca atcatcggct 2518681 tggacaatga agcactcagc acgagaaatg tgaaaacgat cgaaatcaaa ctgtctaata 2518741 agaaaatcaa aacagtcaaa ctaaaggaca attcattttg ggaaaaagtg aagcgtactt 2518801 ttttatagaa aataaaagga caggctgctg cctgtccttt tatgatttct catatacaat 2518861 ctggccgtta atcacggttt ttttaatctc taaaagatga agctgtgcgg ggtcaatggc 2518921 aaacggatca ccactgagaa ctgtaaaatc cgcgtcatag ccttccgcaa tttttccgcg 2518981 tgacttctct ttataaatga taccggcgct accttctgta taaagcttta tcgcttcata 2519041 tacaggtaaa cattcacttt cattatagct tggcccgttt tgctcatgac tgcttttccg 2519101 gaggaccgcg gactggatcc ctagaagcgg gtcaacaggc tcaatcgggg cgtctgaacc 2519161 gcccgcgcat aaaatgcctt tagatatgag ggttttccag gcaaatgcag tcttcatccg 2519221 gtcttttccg agacggtcaa tgacccacgg aaagtcgctt gcaacgaagt gcggctgaag 2519281 gtcaagtgcg atcggcatgc gtgctgctct ctcgattaat tcgttatcaa gcacttgagc 2519341 atgaataagc cgatcatgcc ggccgttttt gggcggatgc ttttctattg cgttcagcac 2519401 tttttcaaaa gcaagatcgc cgattgcatg aacagcaacc tccatccctt tttctctcgc 2519461 tttgcgaatg agccggccaa gggtttcgtc atcgtgaacc tgaacaccat ttgttgatgg 2519521 atcatcctga tatggttctt tcaataaagc cgttctcccg ccaagcgccc cgtccgcaaa 2519581 gattttcata gcaccgaact ccacatacgg gccggacagc ttctccagct gctcccatcg 2519641 atcgacagct tcatgatgaa cgagcaaatg gcagcgaaac ggatactttc cgccagcggc 2519701 agctttctca taagctttca tcggcaccga aacatcacca taataggaca agtcttccga 2519761 atgaccgccc gtcaggcctt ttgtccagca atcctttatt gcagccgtta atgcctcatc 2519821 aacatagtgc tgggagactg gcgggacagc cttcagaatc aaatcctgcg ccttatcaaa 2519881 caggagtccg gtcggctcgc catttgcatc ttttacgatg actccgccgt caggatcagg 2519941 agtatttctt gaaattcccg ctgcttgaag agccgcagaa ttgacagcta ttgcatgccg 2520001 gcatatacgc ttgagcaaga cgggcctgtc aggaaacagg cgatcaagat catgcttagt 2520061 caagtagtca ggtgtctcaa actgattttc attccagcct tctccaatga gccaatcgtt 2520121 tttaggaagc tgccgctctc tttccttcgc agcctgtaaa attgaatctt tcgacgtcag 2520181 tgcggacaga tcgagctgaa gctgtttctc accgtggccg atcaaatgta gatggctgtc 2520241 aacaaaaccg gggaacatca ctgctccgtt caggctgatt tcttctgttt ccggcgaccc 2520301 gtacttttcc ttcaaacgtt catagctgcc ggtgcctttt ataacaccat cctcaacata 2520361 aactgcctca gtccgatcgc cttcttcgag catcgtataa atgaaaccgc cgtgccatat 2520421 cgccttcatt cacgttcact ctctttcttt acgccttttt attggctttg agctgttctt 2520481 cacgttttct taattccact cgtctgattt ttgcagaagc cgttttcggc aggctttcca 2520541 caaattcaat ttctctagga tatttgtatg gagcggtaat cgtcttcaca tggttttgca 2520601 gcattttgac aagctcatca ctgcgttttt catgattttg caggacaaca tatgccttta 2520661 cgatggagcc tctgatttca tcagggcttg cgacaacagc acattctttt acttctgggt 2520721 gcttaacaag cgcgtcttcc acctcgaaag gcccgatcgt atagccggag ctgataataa 2520781 tatcgtcatt tcggctttca aaccagaagt aaccttcctc atcttttctt gctctgtctc 2520841 ccgttaggaa ataatcgccg cgaatttgtg ttttcattct ttccggatct ttaaaatact 2520901 ctttaaagag cgcaggcgta ctgaggtgaa cagcgatatc gccaacctca ccaggtttgc 2520961 agatttcacc gtcttcattt atgatctcca cctgatttcc cggtgtcggt tttcccatgc 2521021 ttcccggttt aataggcgta tctttcaaaa caccaaccaa aagcgtgctt tctgtttggc 2521081 catatccgtc ccgtacctta atgccaaagt gcttttggaa aacatcaatg acttcacggt 2521141 tgagcggctc acctgcggaa acagcgctgt gcagggcaga aagatcaaag cgtttcaagc 2521201 cttcaacctt cgccattaag cggtattctg tcggagtgca gcagaaaaca ttgattttgt 2521261 agcgatttaa aagctctaga tatttttctg ctttgaatct gccgtggtac acaaaaccgg 2521321 ttgctccgct gccaagcacc gctaaaaacg gactccatac ccacttttgc cagccagggg 2521381 cagcagttgc ccagacgata tccttttcag aaatgtcaag ccaagcgccg gcagaagttt 2521441 ttaaatgagc aaatgcccat ccatgtgtat gtacaacacc tttcggctga cctgttgtcc 2521501 cggatgtata agataagaaa gccatatcat ctcttgttgt gtcagctgtt ttaaattggc 2521561 ttccgtccgc ttcaattgat aagaggtttt tccagccggc atcattttca ccaatagaca 2521621 gtgtaatcag tttgtcagcc gtactgacat cccggaaagc gccaataaat tcggagtaga 2521681 cgatagcgcc ttttacctct gcatgttcaa tccggtattc aagatctttc gcgcgaagca 2521741 tttcggagca cggaatgaca accattcctg atttcaggat agccaaataa acagcatagg 2521801 cttcaagcac ccgcggaacc attacaatca gcttgtctcc ctttttaaat ccaagatcag 2521861 ctaaggccgc tccgatttta tttgtttctt ccatcagctt ttcatacgac caagattctt 2521921 gcttgcccga ctcgtcctcc caaagaagag cggttttttg tccagcagca ctgaactttt 2521981 ccatttcatt cactaaatta tattgcacag gggcaattaa atcttcacgt tttaacacga 2522041 acaactcctc actttctcca cccattatac ataaatacag gctctttccg taaggatatg 2522101 cctaaaagca acctctgtaa acatagattt tataggccgc tggtcctttt ttatatgtaa 2522161 aaaatgaaaa agagtgggga tacccccact cctaagccat tatgtgaaat tgtaaattag 2522221 aattgtcctc cgcccatgtt ttgttgagca aaagatacaa gacgttttgt gatctctcct 2522281 ccaacagaac cgttagcgcg agaagttgtg tctgctccaa ggtttacacc gaattcagaa 2522341 gcgatttcta atttcatttg gtcgatcgct tgagcagctc ctggtactaa aaggttgttg 2522401 ctgttacctg agttattgtt agccatgtgt ctcacctcct tgtgagtata gaatgtgtca 2522461 aaacacatgg cttcattcag aaaaactttg gtaattgtat acaggagctg aaaattgatt 2522521 taaaagagtt cagcgaattt atcgttagct tcttgttcgc tataaagggt cattgtctca 2522581 atgttatcta ccgcttcttg aatatacggc tcgaaatcaa caaagctttc aaagtgttca 2522641 attttctctt ttttagggcg tgttttcggg cttggcggtg taaagatcgt gcagcagtct 2522701 tcaaacggct gaatacttgt ctcatatgtg ccaatttccc gtgatttttc gatgatttct 2522761 gttttgtcca tggcgattag cggacgcaaa atcggtgttg acgtcaccgc attaattgca 2522821 tacatgcttt caagcgtttg gctcgctacc tgaccgaggc tttctcccgt aataatggca 2522881 agcccgtttc tcttttctct gattctgtcg gctatctgaa gcatgaggcg gcgggttgcc 2522941 gtcattgtgt aattttcagg aatttgtttt tggatgagct cttgcgtttt tgtaaatgga 2523001 acaatatgaa gtgtcatgct tcccccaaaa cgggacagac atttcgccag atccattacc 2523061 ttttgctttg cgcgctcgct tgtgtatggc gggctgaaga aatgaacagc ttctaccgac 2523121 aatccccgtt tcatcgcata aaaaccggcc acagggctgt caaaaccgcc agaaagcatc 2523181 agcatcgctt ttcctgctga accaactggc agcccgcctg cacctttttc atcacgaatt 2523241 gtcaaaaatg ttgcttcttc cctgatttcg attctgagcg ggatgtctgg gttgcgaaca 2523301 tcgaccgtca atccttctgt atttcgcaaa atatggccgc cgatttcagc gttcatctgg 2523361 tttgtatcta attcaaattg cttatacgct ctctttgtcg cgactttaaa cgtatcacct 2523421 ggtttatact gatctttgat agcctttagt gcggttgcct taatatcatc aaggcggctg 2523481 tcacacttaa ttgccaggct gaagctttga atcccaaaca cttgctttaa atgaggaaaa 2523541 agagcctcag gatcctctcc atttaatgta atcgtcatac gatccctgtt ggaaaagtat 2523601 tttaaattcg gatagtcttt caaaacgagt ctgatgtttt gttttaagcg ctcaataaag 2523661 ctttttctgt ttttgccttt ggtcgaaatt tccccaaaac gaattaatat atgatcgtaa 2523721 ttcatgttct acctcatcat ttcccttaat tttttgatgc caggacgaag cgcgttcata 2523781 aacggttctg ccacatcgct tgtctggctg taatttaaac tgattctgat gctgcttccg 2523841 gcaatctgct ctcctttgcc catctctaag agaaccttgc tgggcttatg ttcttttgcc 2523901 gagcaagccg atgttgtgga gacgaatata tcctgttcct caagcatgtg taaaagcact 2523961 tccgctttaa tccccggtac agagaaatta ataatgtgcg gcgcgctatt catttgaggc 2524021 gtgttgataa cgacgccctc aatttcactc agcctattca taaacaattc ctttacggca 2524081 gtcatcgtgt caagccgtgt gtcaaaatca gcagaggcca gattaatggc cttggcaagc 2524141 gaaaccgcac cagcagtatg ttctgttccg gcccgtatgc ctttttgctg agagcctccc 2524201 gttatgagcg gaataaggcg tgttccttct tttacaataa gtgcgcctgt cccctttagg 2524261 ccgtgaaatt tatgccccga aattgaacat agatcaatgc cggccttttc aattgccaag 2524321 ggcactttat agatgccctg cacataatcg acgtgaaaca aaatgttcga atgctctttc 2524381 agcacttctc ctgccgcttc aatcggctgc acggaaccga cttcattgtt cacatgcatc 2524441 atgctgacaa gcacggtatc gggacggatg gctgctttta gatcttcaat agaaacaaat 2524501 ccgtcttcat tcacagaaag ataagtgata tcaaacccga acaactcttt cagctgttct 2524561 aacgattccg taacggatgg atgttcaata gaagtggcaa tgatatgttt gcctgttttt 2524621 atctttgaca aagccgctcc ttttaaagcc gcattattgg cttctgtggc gcctgacgta 2524681 aatacaatat catatttttt taggcctaag gaccttttga tttgattttt ggctgcttga 2524741 agcagctgtt ccgtttcggc tccatatcgg tgcaaagatg aaggattgcc aaagtatcgg 2524801 ctgctcgtct gttcatatac gttcaagact tcatcgtaag gcttcgtcgt tgaactatta 2524861 tctaaatata tcatcttttt tactccttta tgaaagcggt acaaggtatg atatttatgt 2524921 taccataaca aaatttaata gaaaattacg aaaaactagt attgacttct aattttttta 2524981 ccatataata agatttgttc gtttcgtcat attatctgac aattaattga cagaatattt 2525041 taacataatt attaggagga tttttttcat gaaacactca ctgcctgtca aagataccat 2525101 tattattggt ttcatgctat ttgcgttatt ctttggagca ggaaatatga tttatccgcc 2525161 ggaacttgga caagcagccg gacacaacgt ctggaaggcc atcggcggat ttttactgac 2525221 aggggtaggc ctgccgcttc tcggcattat cgccatcgca ttaaccggta aggacgctaa 2525281 aggccttgct gacaaagcgc accctgtttt cggcacaatc tttactgtcg tgctttattt 2525341 atcaatcgga ccattattcg ccatcccgag aacaggaact gtttcatatg aaattggcgc 2525401 tgttccgttt ttgactggtg taccagaaag actttcttta ttaatattta cacttatctt 2525461 tttcggcgtt acgtactatt tagcgttaaa cccatctaag gttgtggatc gagtcggaaa 2525521 aattctgact cccatcaaat tcacaattat tttaatcatt gttctcaaag ccatcttcac 2525581 gccgatgggc ggattgggcg ccgtgacaga agcatataaa ggaacaccgg tttttaaagg 2525641 atttttagaa ggctataaaa caatggacgc acttgcttca attgtatttg gcgttgtcgt 2525701 tgtaaatgct gtaaaaagca aaggcgttac acagtctaaa gctcttgctg cagcctgcat 2525761 taaagcaggt gtgattgccg ctttaggcct gactttcatt tatgtatccc ttgcttattt 2525821 aggtgcaaca agcacaaatg ccattggtcc tgttggtgaa ggagctaaaa ttttatctgc 2525881 gtcttcccat tatttattcg gttcattggg caacatcgta ctcggagcag cgattacagt 2525941 cgcatgttta acaacaagca tcggccttgt cacatcttgc ggccaatatt tttcaaaact 2526001 tattccggca ttatcatata aaattgtcgt tacgattgtc acgttattca gcttgatcat 2526061 tgcgaatttc ggactcgcgc aaattatcgc gttttctgtt cctattttat cagctatcta 2526121 tccgcttgcc attgtcatta tcgttctttc cttcatcgat aagatcttta aagaaagacg 2526181 cgaagtgtac atcgcatgct tgatcggtac aggacttttc agtattttag acggtatcaa 2526241 agcagccggt ttttcacttg gatctttaga tgtgtttcta aatgcgaatc ttcctcttta 2526301 cagcctcggc atcggctggg tgcttccagg aatcgtcgga gcggttatcg gctatgtgct 2526361 gaccttattc atcggaccat ccaaacagct taatgaaata agttaatgtc acagaacgcc 2526421 tgcgttattg cgcaggcgtt ttgtaataaa aaaagagcct gctcattaca ctgcgggctc 2526481 tttttcatgg tcgtgattat ctaagcggat atgtcagctt tgattttttc aactgcacct 2526541 ggcgcagcct tttctacagc ggcagcggca atttcataag agtcgtcata atcaaaagca 2526601 taaaaacgtc tttccgcttc tttcagctgt tcagataaaa tatgattctg gcttctgaac 2526661 cggtttccga actgaatgat tttttcaatg aggatgacct gctcgacaag ttcctctgat 2526721 tcccggcttg ccctgttgac gatatcttct gcttgtttca aatgggctcc ggcttcttcc 2526781 atatttaatg gaagttcgtt tagttgattg accgtttctt gaatatgatg atgcgcgttc 2526841 tccagcatct cttgaatatg gctcggaatg cctggaatgt tgctagtctt cagcagtctt 2526901 gctgtctcag aaattgtttt tttcaaattg ctgagcgtct ccctcgcctg aagctcttct 2526961 tttctcagcg cttgcagatt ttcacgatac tcggcatgct cttttttcac ttcttcaatt 2527021 tgcttctcta ttgaagcaac ttcttctact aaaagtgagt aggcgacatg ctctgcatca 2527081 agcttatctt taacggatga tagcagcttt ccaatttcat caaggcgctt ttcaaaagcc 2527141 tgctgtttgc cgagctcacc ggctgtcagc ctgtagcttt ccttcaccag ctcagtttcc 2527201 gctttcgtat gctctttctc ttctttaagc ttgtcgtaag caataatcaa ttcaggcatt 2527261 ttgcttagta cggattgacc ggcttcaact tcgccctcca gctgctgata aacagattga 2527321 atattttcgt caatgagctg caggattgcg gacgcttcat caatatccag ttcagtcatc 2527381 aggacatgtt ccgctcgttt cagctggttt gacagatttt ctaattcctt atcaagctgg 2527441 atatgctcaa gcttgtaccc tttttctttc atttcgccat agccatcctt gagctttgca 2527501 atctgtccgg gcaccgtctg tttacagtca gctaacagct tcggcacatc atctatgtat 2527561 gactgaagcc gttcaagatt gcggtcctgc tcaagcagta cttttcgtgc agtaatatag 2527621 tttccgcctt ctgtttcttc ttcaaattgt ttgatgccgc tccaaatttc gtccagatcc 2527681 ttttcaaggc tgtcataaag ctccccgtaa aggtggctgt aagccagcag gttttttcga 2527741 gatttcgaat agcgctccct cacctgttca atctcttcac ggctcttttc ctcacttgtg 2527801 acaagatcgc tgatttcccg aagaatcttt tcaatgcttg attcagccgc tgtcagcagg 2527861 tcgtcgatat gaacgagcac ttgattggcc tttttaaacc ggtatttgtc tgcattttcc 2527921 tcggcatcat aaaggagctc ttcaactttc ggcatgtggg ctgtgacaat ctcatcccat 2527981 tcttcacgcc acttctcaaa gaactcttct gtctgacccg tcatttttaa atgttttatt 2528041 ttagacattt cttccacgat cgaccgattc agaatttcaa tcttccacga ttccagccgg 2528101 tcgatttcgg cgtagatttt tttcctgaaa aagtagcctg ccgcaaacag cgcaagcagt 2528161 acaattaata atccaatgac aaactccata atgagccccc ttgctgttta ccttaatctg 2528221 tcagggtgtt ttatttattc agaaagattt caggatatgt attgagaaaa actgtcgttt 2528281 tcattgttat tatgatacca tgtaacaaac attttttgac cagaaatcaa aaactttttg 2528341 tgcaaaatcg gcaggatttg actatttttt catggggtga catcaatgca aaagcgagac 2528401 ggacatattc acacaccatt ttgccctcac ggctccaatg acacactcag acaatatgca 2528461 gaagaagcct taaaaaaagg gttcgaatcg attactttta ccgaacacgc cccattgccg 2528521 ccatctttta ccgatcccac gccgctgaaa gacagcgcga tggcgcaagc ttctttggaa 2528581 cgctatattc atgaaatttc cggattaaaa aaagaatatc gcggacagct tagcatacgg 2528641 acagggcttg aagtcgatta tatcgctgaa tttgaagacg aaattacatt attcctagac 2528701 acatacgggc catatttaga tgacagcatc ttatccgttc attttttgcg cacagactct 2528761 tcctatctat gccttgatta tgacgagcat accttcaaag agctgatttc agcctgcgga 2528821 agcattgaag cggtatatga acaatattac cggagtatct attcttccat tgtagcatct 2528881 ctcggcgttt ataagccaaa aagagtcggt cacatcacac tcgtccaaaa attcatcaag 2528941 ctgtttccat acagcatgtc agagcatatt cgcggcctcg tttctctgtg cctgaatgcc 2529001 attgaagaaa acggaatgga gctcgacttc aatacttccg gcttaagaaa aacttacgct 2529061 ggcggtattt atatcgagga ttggatgctg aatgaagcga agcaaaagaa gatcccgctt 2529121 gtgtttgggt ctgatgccca tcaagcggga gatgtcggat atgcgtatga ggcgtttttg 2529181 gaacggtgct agttggtgag cgccacgtct cctgtccgga agacgcttct gatccaaatc 2529241 ttgatttctt caaaatacat tttataaaaa tacggctcgt gcggctgcat gtagagtact 2529301 tctgaaatat attgaggctg gagatagggc atcatcaaga gagattttaa ttggagaata 2529361 aaatgaggca gcggcagcgt taaatattca cgctgttttt ctccttcctc aatgatcagc 2529421 tggaagatat acttttcctt cattagatat gtcgacataa tttccctgat taatgtggag 2529481 tcaattgtga cttcccggta gacaaaacga gttaattgac gatgattatg ctgataggat 2529541 aaaatatcga aaaccaattg aagaagctgt tcctgcgtgc tttgagtaga gatattgctt 2529601 gccgctgttt caagcgtttt gctgtagcct tcgtaaaact ctgaaactaa gtgttccatc 2529661 aagcctcctt tgcctttaaa atagtaggag atgtgcgcaa catttacatc agctgacttt 2529721 gcgatttcac ggacagacgt gccagaaaat cctttttggt taaaaagcat gacagcagat 2529781 tcaataattt tgtctttggt gcttactttc atacggctca ctccttcctc ttgatactat 2529841 tcaagcagaa agccgctgtt cctgtaagaa cttatcgaca aatgccggca gaaaagccgg 2529901 aactttgttt tatattatag aaaaagtgag ggttttccat gttccatgtc gaaaaacaat 2529961 ctggagataa agaaaaagac tatcagcttc tgctaaaaca gctcgaagcc atgaccgaag 2530021 acgaaacaga ccaaatagct aactatgcaa atgcctcagc actgctgtat cattcgctgc 2530081 ctgaagtcaa ctgggcgggt ttctattttg ccaaagaaga ggatggacag cttgtgttag 2530141 gtccgttcca aggcctgccg gcatgtgttc ggattccttt cggcagaggg gtttgcggca 2530201 cagcgtacgc aaacggaaaa gtggaacgta ttgaggatgt aaacgcgttt ccgggacata 2530261 tcgcctgcga tgcagcgtct caatcagaaa ttgtgcttcc gattcgtgta gacggaaaaa 2530321 ttgtcggcgt cttggacatc gacagcccag tgaaaaaccg tttcgacgaa attgatgaaa 2530381 aatacttaac tcaatttgcc gaaacgctag aaaaagcgtt agcgcagtaa tataaaagcc 2530441 caaaactgat atcgttttgg gcttttttta ttttattgag tcatgaatca tcaagcggtt 2530501 tttcccgctc cgtttcgcgc tgtagagcgc ttcatctgcc tcatgcacaa gctctttcag 2530561 cgactttttt gtttctgtcg tccagcagga gataccgcag gaaatggtta cctcgggttt 2530621 cgtatttttt ctgaccgcgt aaaccagtcg ctcggtaatc cgtttcccca ctgcaaccgg 2530681 cacatttggc aaataaatcg ccagctcctc tcctccccag cgggcaccga catcatgctt 2530741 tcggatgttg cttttaatca ctgaagcgac ttgaattaaa atctcgtccc cagtctgatg 2530801 gccgtacgta tcatttacat ttttaaaatt atcaatatca acaagaataa aaacaccctt 2530861 ttgatggatt ttcatgctgt attgaatttt ttcatctaaa tacgctcgtg aatacagttc 2530921 agtcagctga tctgttttca cgagatgctc aaggcggtcg cgaagcattg aattggttac 2530981 agccagtgtc gcgtgatgaa tcagcgcctg aaacagcttg tacatttcaa atgtaaaagc 2531041 gtacagctcc tgtttcaata aaaccgcaaa gcctaaaagc cggtcgtttt gaatcatcgg 2531101 agcagccatc agcgagccgt accccgcctt cccaaaaaca gactggccat tcccgatgaa 2531161 aacccctttt tcaccttcat acagcttttc tttcagctca ttataaaaat ctgacggctt 2531221 cgcttcttta aaaaatgctg tgctgcctgg gagcaatgtt aggttttcaa aatggtctat 2531281 atgaaaaaat cccacttctt ctgcctgaaa cgattctgcc attctcacag ccagatcatt 2531341 cattgtatca gtcaatgtca gccgctgatt caggcgtcgt gatgtttcat taatcaattc 2531401 caaatttgcg atgcttgctt tggattgttc gtagagctgg gcattttcaa acgcttttcc 2531461 cgcggcgttt gctaacagcg acatttcatc aaggcaggca tcagtaagaa agctgtcacc 2531521 cgttccttca gccttcaaca ccccgtatgt gccctgctgt cctttgatcg gaatataggc 2531581 gacagattca tttttccgca aaatgtctcc ggacaaatac actttgagcg caaaggaatc 2531641 ggatttttcc ccttccatat acagctcttt tgcaggaatc cctaaacatt ggtcttgatc 2531701 gtgcgatata aataaagaaa actcaaaaag agaaaatgtg cttgtcaagc tttctaaaag 2531761 ctgcttcagc acatctgtct gatcaagcag tgaatggaac agctctgtca ttttgtatat 2531821 ctttttttgg tagatcgttt tgttatagag tctttcctgt ttcatcgact ggtttaaaaa 2531881 tgaagcaacc acgtccggaa gcccttcagg aatctcttca tcctgcctgc acgcaagatg 2531941 gaaacgcctg ccggagccgt cctcaatcag ataacatgaa gcgtttattt ttgaagcgga 2532001 aaaacgcgct tcaccatctg ccagttttgt cacaaagtct gatggtgacg gtgtaagcga 2532061 aacacaaagg gttgaaaaat aggtttgaat agccgaagtc agccatatga aagagtcggt 2532121 gaatgtgact ttttcagatt tggttaataa aaaatcgagc atatgataat gaaaggcgga 2532181 taattgatct ttagtttgtt ctaccatgtt tttatcacct aaaagtttac cactaatttt 2532241 tgtttattat atcataaacg gtgaagcaat aatggaggaa tggttgactt caaaacaaat 2532301 aaattatata atgacctttg tgtgaaatat tgcagccttt ttgttcagct tctatgtttt 2532361 cattttgttc cttatcaata aggtgtatcg tgtaactctc tgctgctgga gcgaggatac 2532421 atgaaaacaa aatgtgcatg gtcgaataga gcagacggtt tttattttcc acaaaaataa 2532481 aaccaaagga ggagtcacat tatggctcgc tatacaggtc catcttggaa actgtcccgc 2532541 cgtctaggaa tctctcttag cggtacagga aaagaattag aaaaacgccc ttacgctcca 2532601 ggtccacacg gcccaggaca acgtaaaaaa ttatcagaat acggtttgca attgcaagaa 2532661 aagcaaaagc ttcgtcacat gtacggtgta aacgaacgtc aattccgcac tttgtttgac 2532721 aaagctggca aactagctgg taaacacggt gaaaacttca tgattctttt agattctcgt 2532781 cttgataacg ttgtgtacaa gctaggttta gcacgtactc gccgtcaagc tcgccaattg 2532841 gttaaccacg gtcacattct tgtagacgga agccgcgttg acatcccgtc ttacctagtg 2532901 aaacctggtc aaacaatcgg tgttcgcgaa aaatcaagaa acctttctat catcaaagaa 2532961 tctgttgaag tgaacaactt cgttcctgaa taccttactt tcgacgctga aaagcttgaa 2533021 ggtactttca ctcgtcttcc tgagcgttct gaacttgctc cggaaattaa cgaagcgctt 2533081 atcgttgagt tctactctcg ttaatcgttt taaaaacccc tgccgctatg cggtcggggt 2533141 ttttttatcg gctttcgcct cttgctggcc aacactatct tgcgcctgct gctcccaatg 2533201 atcccgctgc agccgttctt ttgcaatcgt acacatgaga ttcacgcttt agcgctcctt 2533261 tcatttaaaa ggtggtgatt ggtcgtgttt gccctatcta atatactctt ttcctttcat 2533321 tcctatgcgg taaacaaaaa gatcctttgc cttcagtggc aaaggatctt tttcttattt 2533381 atacgtcaca aggaagtatt ttttcttccc gcggcgcaga acagtaaatt ggttttcgat 2533441 gcggtcttca cctgataggg tataatttat ttccgtctgg cgttcaccgt taatgtaaac 2533501 agctccgttt tggatgtctt cacgcgcttg gcgtttagaa ggagataatt tagattgcac 2533561 caacacatct acaagtgaaa gctcttgggt gctgtcaact tccatagaag gaacatcttt 2533621 aaagcctact tttacgtctt gagcagaaag ctctttaata ttgccgctga acagcgcttg 2533681 ggagatgttg atggcttgct ccagcgcctc gcgtccgtga acaagtgatg tcacttcttc 2533741 tgccaggcgt ttttgcgctt cacgtttttc tggcgccgtt tctgtttttt cagcgtatgc 2533801 ttcaatttcc tcttttgaaa ggaacgtgaa gtatttcaag tatttgacaa cgtcacggtc 2533861 gtctgtgttg atccagaatt gatagaattc atatggcgat gttttttctt tatcaagcca 2533921 gatcgcgccg ccttccgttt ttccgaactt cgtgccgtct gcttttgtga caagcggaat 2533981 cgttaggcca aacgcttttg ctccttcttc ttctgatttt ctgatcagtt caagacccgc 2534041 tgtgatgttg ccccactgat cgcttccgcc gatttgcagt ttacagtttt tgtctctgta 2534101 aagatttaag aaatcataag attgaagaat catgtagctg aattccgtgt acgagatgcc 2534161 ggattcaatt cttgagctga ccgtatcttt tgccagcatg taattgatgc cgaaattttt 2534221 accaacgtca cgaaggaaat cgatcacatt cattttgccg atccagtcaa agttgttcgc 2534281 gatgacagct gggttttctg ctgcttcaaa atctagaaat ctggacagct ggtttttgat 2534341 tttttgggac cattcggata cgatgtcagc agtgtttaat gtacgctctg ctttttttcc 2534401 gcttggatca ccgatgaggc ccgtcgcgcc gcccacaagc gcaatcggat gatgccctgc 2534461 aagctgaaaa cggcgaagtg ttaaaatagg cagcaggtgt ccgatatgca agctgtctgc 2534521 tgtagggtca aagcctgagt acaagcggat tttttcttca ttcagctgtt tatttaaccc 2534581 ttcttcatct gtcatttgct gaatcaatcc gcggaaggat aagtcttcaa gtaagttagt 2534641 cataagataa agctcctttt ttaattaaaa taaaaaacgc cccttcgttt acacgaaggg 2534701 acgattgatt atcgcggtac caccctacta ataagagaat gcaaacattc gtcttatcac 2534761 tttgcctgat aacggatcag gtccgttctt tcactactga aagcctggcc ggctttgttt 2534821 gcaaaagcgg ttcatgagtg tattcgatat atccgtctgt gctgattttc accggccatc 2534881 agctctctgg aacgtaagga tattctactt gtctcaatct ttaccttttc atatgaagct 2534941 atatcatttt taacataaat aaaatcctgt gtcaacgccg ccttttaatc ctccattgtt 2535001 gacagatctc cagccggcag attaagctcc catgccttca gcacgcgcct catgatcttt 2535061 ccgcttctgg ttttcggaag cttatcttta aattcgatct cacgcggagc cgcatgggct 2535121 gcaagaccct gctttacaaa taggcggatc tcttctttca gtttatcaga cggctcaaat 2535181 ccttccctga gtgcaataaa ggctttaatg atttctccac gcaccgggtc aggctttccg 2535241 ataacgcctg cttctgcaat agccggatgt tcgacaagct tgctttccac ttcaaatggg 2535301 ccgacgcgct caccggaggt catgatgacg tcatcaactc tgccttggaa ccaaaagtat 2535361 ccctcttcat ccatgtaagc agaatcccca gacacatacc agccgcccgg catgaaatac 2535421 gattcatact tttcagggtt attccaaatg gtatgcatca tggaaggcca gccctttttg 2535481 atggcgagat tgcccattcg gtacggcggt agctcgttgc cttgattgtc aacgatcgct 2535541 gcctccactc ctggaatcgg cttacccatt gaacccggtt taatatccat gcaaggatag 2535601 ttgcagatga gctgactgcc cgtttcggtc atccaccagg tatcatggat tcgtttgtta 2535661 aaaactttat gtccccatct gatgacttcc ggatttagcg gctcaccgac actgagcaca 2535721 tgccggagtg aagttagatc atatttcgca gccatttcat ctcccgctcc catcagcatc 2535781 cgaaaagctg tcggcgcgct gtaccagaca ttgacgccaa gctgttcaat cgttccatac 2535841 cagctttccg ggctgaaacg tccgccgacg atgacatttg tcgctccgtt cagccacggt 2535901 gcaaaaatgc cgtataccgt acctgtcacc cagcctggat cagccgtgca ccaataaatg 2535961 tcttcttcct ttaaatcaag gacccacttt cctgtttgat attgctgaat catcgcttca 2536021 tggacatgca acacgccctt tggcgtacca gtggaacctg atgtatagtg aagcagaaag 2536081 ccgtcttttt tatccatcca ttcgatatcc aatcttgtgc tttcctgttt cgctgcttca 2536141 tcataattga tgatattcgt gccgctctca gcctctcccc cgactacgaa gacatgctgc 2536201 aagtgaggca gtttgtctac cggtattctc tccagcagct caggcgttgt gacaacaacc 2536261 tttgcctcac tgttttcaag ccggtctttc accgctccct ccataaatgc ttcgaacagc 2536321 ggcccggcga tggcgccaat tttgattgcg ccaagcataa taaaataaag ctcgggtgat 2536381 ctcggcataa aaataaaaac gcggtcccct ttttccacat ttccataccg tctcagcaca 2536441 ttcccggctc tgtttgattc ttccttcatt tctttaaatg tgtatttttc atcccttttt 2536501 gcgtctttat aataaagcgc tactttgttt tttcgaaacg attcggcatg gcggtcaatc 2536561 gcttcatacg ccgcattcag tttccctgtc tcatgccaag agaaatgttt ctctgcctcg 2536621 gcccaatcaa aatgccggta cgtttcttca tagtttttta agttatgatc cccctctatt 2536681 gctggtaacg ctttcaagtt catgcccaaa catccccctt tgctgaagtt gtcacaatta 2536741 ttatagtata tattcatatt cttctcaatt tttaaaatat aaaccatgtt gaaaacgctt 2536801 tataatttgg tattcttaaa gaaggcatgt atttttgata agaattgatg ggacggtgaa 2536861 ttagtggaac atcataaaac ataccattca gcaaacatca aaacagcaac cggctcttta 2536921 ctgatagaag ggcctgtctc tccagaggat ttggcaggtt atgagtttca taaagattta 2536981 accgcatttc gcccgcctcg cgagcagcat gaagcgctag tcgacattgc aggccttccc 2537041 gaagggcgca ttattattgc cagagacggc cgaaccattg tcggctatgt cacgtattta 2537101 tatcctgacc cgctcgaaag atggtctgaa ggaaatatgg aggatttgat tgagctcgga 2537161 gccatcgaag tagcgccgga ctatcgggga tgcgctgtcg gaaagacgct cctgaccgtc 2537221 agcatgatgg atgaacaaat ggaaaactac attgtgatga cgacagaata ttactggcat 2537281 tgggatttaa aagggatgaa aaaagatgtg tgggaataca gaaagatcat ggaaaagatg 2537341 atgaatgcag gcggattggt ctggtttgca acggatgagc cggagatcag ctcccaccct 2537401 gcaaactgtc tgatggcccg cattggaaaa aacgtcagcc aagaatcaat tgagcaattt 2537461 gacaggctcc gtttttatca tcgttatatg tattaactga cactgacaaa ggggaaaaaa 2537521 taatgattgt tgagcaaatc atgaaaagag atgtcattac attaacgaag acggatacgc 2537581 ttgaaacagc aatatgcaaa ctgaaggaat tccatatcag gcatctgcct gttgtagatg 2537641 aagaacgaca cgtgatcggc atgattacag acagggacat gaaacaggcc agcccgagta 2537701 tttttgaaga aaacaaacga agcctatttc tcacacgaag cgtagattca attatgaaaa 2537761 aggatgttgt ctgcgcccac ccgttagatt ttgtcgaaga aatatcagcc gtgttctacg 2537821 agcatggcat cggctgccta ccagtggtac accatcaaaa attaataggc attttaacaa 2537881 aaaccgattt gctgcggacg tttgtcaaat tgacaggcgc tgaccagccg ggctcgcaaa 2537941 ttgagataaa agtaaacgac atcaccaaaa gcctcgctga gatcagcagt ctttgccaag 2538001 accttcaagt gaaaatatta agcgtgcttg tttatccgca tgacgatccc ggtgtaaaag 2538061 tgcttgtctt ccgtgtaaaa acgatgaatc cgctgccgtt tttgcaggca ttacaaagaa 2538121 atggacacca cgtcgtatgg ccgtcagagc aaagggatct gctatgagag acagtgtatt 2538181 tatctattct ccatcctacc aaacctatat gtttcatcag gagcatccct ttaatcagca 2538241 gcgggttctg ttaacatatg atttgcttaa gacgatcaat gcctttgatg atggagacat 2538301 tgtcaccccc agactcgctt cagaagagga gctttccctt gtccacacgg acgattacat 2538361 tcaggccgta aagcttgcgg gcgccggaaa gctccccgct gaagaaggag aaagctacgg 2538421 gctcggcact gaagacacac ccgtctttgc cggcatgcac gaagcggcat cactcttggt 2538481 cggcggcact ttaacggccg cagactgggt catgtcagga caagccctgc atgcggcaaa 2538541 ccttggcgga gggcttcatc acggctttcg cgggagagca tcaggattct gcatatacaa 2538601 cgacagcgct gtggctattc aatatatcca gaaaaaatat agcgccagag tgctttatat 2538661 tgatacggac gcccaccacg gggacggtgt gcaatttaca ttttacgata atcctgacgt 2538721 atgcacgctg tccattcatg aaacaggaag gtatttattc cctggaaccg gtcagatcca 2538781 agaaaaagga agcggaaaag gatatggcta ttcctttaat attccgcttg acgcttttac 2538841 agaggatgat tcttttcttg aggcttaccg gacagcagct tcagaagtcg ccgcgtattt 2538901 cgagcccgat gtcattatca gccaaaacgg cgccgatgcc cattactacg acccgctgac 2538961 gcatttatca gcaacaatca atatatacga agaaatcccc cgtcttgcac acactttggc 2539021 tcatcaatat tgcggaggga aatggattgc agtcggaggc ggcggatatg atatttggcg 2539081 tgtcgtgccc cgcgcctggg ccagaatatg gcttgaaatg aagggaattg acccgggtca 2539141 cgagatcccg ccggaatgga ttgttaaatg gcaaaaacaa tgccccgtgg cccttccgtc 2539201 gagctggagc gatccggctg atttatatcc tccgattccc cgcaagcctg aaattacaga 2539261 aaaaaatgcc caaactgtca gcaaagcatt atatgcgata cgttctgaac agcaaagaac 2539321 aaagtaaaaa acgaccttta cgaagaggtc gtttttgatt ttttaatcac tatttccaca 2539381 cgccgatttt ccttcatgtg ttcatttgtc ttgttatcct ttactggctt tgtatccgca 2539441 taaccgacag caataaagcg cttggaggga agcttctctt tagacgtgaa gtattgaatc 2539501 actccacttg cccgtgctgc tgatagctcc cagttcgacg ggtatcggta tgtcgaaatg 2539561 tttcggctgt ctgtatgtcc ctcaacctga atgtcatttg gaattgtttg aagaagaacg 2539621 gcaatttggt gaagaagtgt ttcggcattt ttcagcacct ttgcctcacc tgtatcaaac 2539681 agcacagcct cctgaagaac gagcacgaca ccgcgttcat cccgtttggc tgtcatttgg 2539741 gccttcaaat gattgtcttt tatatatgta tttactttct tgagaagctg atcctgctga 2539801 tcctcttgct tcttcgtatc agatggggat gtattctttt tttctatgga tgtttggtcc 2539861 ggctgaagcc cgttgccttc cttctggatc gagtccactg ccgctttgaa tttttgcaga 2539921 tcgatttggg acatcgaaaa gagtaaaata aagaacacaa ggatcaaggt gatcagatct 2539981 gtaaaggtta ccatccagct ggatgaagat tgactgtttt ttccgcttcc attccttctt 2540041 tcaaaacgtt ctcttctaag cttcatgtac agatcccttt tttgttttta cttgttttgg 2540101 ctgcttctgc cattcttccc gtgagctgaa aacgaccagc tggctttcaa ggttgcgcgg 2540161 gttttttccg gattgaacac cgataatccc ttccaccatt acctgcttga tgaaaatttc 2540221 actttctgtt ttctcttcaa gcttagccgc gatcgggttg aagaccatat ttgccagtaa 2540281 tgaaccatat aaagtcgtca gaagcgcaat ggccatgttt ggtccgagca tatgcgggtc 2540341 gtttaagttt ttgagcatca gcacaagccc gacgagtgtt ccgatcattc cccatgccgg 2540401 agcgaattct cccgcttttt caaaaactcg ccgccctttt cggtgccgtt cctccattgc 2540461 tgcgatttct gaatccatga cgagccgaat cgtttcttca tcccagccgt caatcgctaa 2540521 aagcagccct tttttcaaga atggatcttt gatttcccga gcctgatcat ccaatgataa 2540581 aagcccgtgt tttcgcgcgt gatcggaaag ggaaacaaag gttttcacaa gatctttcac 2540641 attgtcttcc tggcggatga atgcctgctt taacacagag ggcgcttttt tcagctcact 2540701 tggcggaaaa ctgataaaaa cagcggcgca aagtccccct gttacgatga agaaagaggt 2540761 cagatcaaga aaagagcgga aaccgcttac tcccgatcct gaaataatcc cgataacaat 2540821 aataatcgtt cctaacacaa atccaacagg tgtaagataa tcaaaacgtt tcatcatttc 2540881 tccccatgaa aaaagcaaga attcaccata aaggtgaagc ttgctctttg tttttcttat 2540941 gacttggttg actttctaag ctctatacgg tgcggcagtt cgacgatatg ctcttcaacc 2541001 ggctctttat tcatgagctt cgtcagcagt ctcatcgcaa cggcgccgat atcatatgtc 2541061 ggctgaacaa ctgttgaaag ctgaggacga accatgaggc ttaatcttgt attatcaaaa 2541121 ccgataatgt cgagatcctc cggaatggat aagccctgat cctgagcggc atggataatg 2541181 ccgagtgcca tttcatcagt tgcagaaaga atggctgtcg gttttttatc caggctcatc 2541241 agatgctgca gtgcttcgag tccggaatca tatgtgtaat ccccttcagc tacaaattgt 2541301 tcattaaacg gaaggttcgc ttcttcaagc gcacgtttgt agccttggag ttttttcgaa 2541361 cggttgatcg gttctgccat tggtccggaa acgaacgcga tgtctgtatg tcctttatca 2541421 accaaaagct tcacggcatc ataaatcgcc tgttcgtaat cgatagcgac tgacggtgtt 2541481 tcctcctgct cttctacaga agcggcaagt acaatcggca ctggagaacg cttaaattcc 2541541 gccacatgct cgtccgtaat gtttccgccc ataaacacga tgccgtccac ttgtttgccg 2541601 agcattgtgt ttaacaagtg cagctctttc tccatgtttt ggtcagagtt gctcaaaata 2541661 atattgtatt tatacattgt cgcgatatct tcaattccgc gcgcaagctc tgaatagaaa 2541721 atgcttgaga tatcgggaat gatgacacct acagttgttg tttttttact tgccagccct 2541781 cttgccaccg cgtttggacg gtaaccgaga cgttcaatgg cttccaagac ttttttcctc 2541841 gttgtcggtt ttacattcgg gttgccgttc acgacacggg aaacggttgc catgcttaca 2541901 ttagcttctc tcgctacatc gtagatcgta atattgctca tcctaaaacc actcctttta 2541961 ctggatacac ttatccttat ctatagcata aacactttat gtagagaaat gtcataatgt 2542021 ccgaatttat gtcgtttatg atttgtaagc gtaagtcagt agtgtacatt atttttcatt 2542081 attcatcaaa tttaattact tctcatgaaa ttatacacgt ttttatagat gatgaaaacg 2542141 tatacttggt ttttataact aaataaacga gaaagcataa aaaaaggccg caggcgcggc 2542201 cttttggatt gttcaattaa gcgttgactt tcaccattgg cttcagttca ttcagccatt 2542261 tttcgaattc aggaatcgcc atttgctgag cagagtcaga aagtgcgact gacggatcag 2542321 ggtgaacctc agccattacg ccatcagcac cgatcgctaa agcggcttta gctgtcggaa 2542381 gcaagaggtc acggcggcct gttgaatgcg taacatcaac aaagactggc aaatgcgttt 2542441 cttgtttcaa aatcggcaca gctgaaatat ccagcgtgtt tctcgttgct gtttcatatg 2542501 ttctgattcc gcgctcacaa aggataattt ggtcatttcc ttgtgacatg atgtattcag 2542561 cagcattgat gaattcagag atcgttgcag caagaccgcg cttcagaagc actggctttt 2542621 tcacggcgcc ggccgctttc agcaattcga agttttgcat gttgcgcgct ccgatttgaa 2542681 tgacatcaat gtagtccagc gcttcttcga tatgagccgg agttacgatt tcactgataa 2542741 ccgccagatc aaattcatcc gctacacgtt ttaaaatttg aaggccttca acaccaagcc 2542801 cttggaaatc gtatgggctc gtacgaggct taaaggctcc accgcgcaaa attttaatcc 2542861 cttgtttttt cgcagctgca gcgacttcag ctacctgctc atagctctct accgcacatg 2542921 ggccgacaat gaatctttgc tggccgtctc cgattttttc gcctttgata tcaacaattg 2542981 tatcttcagg ttttttcttg cgggagacaa gcagcgcttt gctgtgatct tcttcctgaa 2543041 gctctaaacc ggctttgaat atctctttaa aaatgtgctg gatggttgaa ttttcgaacg 2543101 gcccgtcatt gttttcaatg atattgttta acattgtgcg ttctctgaca gggtcaaatc 2543161 ggttgacacc ctgtgcttcc ttcgctttac cgatctcttt tacaacattg ccgcgttcgt 2543221 tgattaattt taaaatttgt aggtttaatt cgtctgcttt ctgccttaaa agctctaact 2543281 ctgtgttgct catttttttc atcctttccc tgcacattca ttttttattt tgtagttatc 2543341 atgcatctta ctataagtaa ttccaaatgg aaatactgaa atacaaaaaa ttttataaaa 2543401 actctacttt attacccaaa cgcttttaag tgataaagta atctatgaag ctatcctaca 2543461 tgatgtgagg gcaatgttca agggtttttt acaaaaaaaa gcgccagatg atatctggac 2543521 gcttttttct atgacaaatg ctgctcaata gcggcttctg taatttgtga atgtgaggta 2543581 tgccatttca cttcaccgtt ctggatgatg aatatctgag ggctttcatg cttgacccca 2543641 tatgtttctg caatgaaatt ggacagcggc cgggcttctt gtacttgaag atagtaagcc 2543701 ggcacatcct catgctgatt tgcaaaggca tcaaactcat gaaatgctgc ctggctgatc 2543761 gggcatgtgg tgctgtgttt caagaagacg aaaacgcctt cctgttctgc aatccgttta 2543821 aattcttcct cagattgaat aagctgttta gccatgactc aagctcttcc ttccctgctc 2543881 agcgattcaa ctgctcagcc tgtttttgtg catctttcag ttcgtctttt acatcttctt 2543941 tcgtctggag gacttgatct tttgtttcat cagctgcctg catcgcttct tccctcatat 2544001 cttgcattgc agtcgatgaa tccgttttgt cagatttgga acggtctctc aaatccttta 2544061 ccttgttcat gatctgtcca gactgatccg ctacaagctg tgtgatgttg gaagttttgt 2544121 cttttgcgat gctgacatat tgcgtgcctt tttccttcgc atctgccgtc attttatcag 2544181 ttttgtcccg taaggcaaca gcctggctgc cgagatcgtc gcgaagttct ttgcctgatt 2544241 taggcgctag aaaaagagct gtagtggcac cgatgattcc cccgattaaa gttccgatta 2544301 aaaaatcttt actattaatt ccatctttgc tcatcattat tcctcctctt agtatttttt 2544361 tctcttacag ggctgatttt ttcttttgct tccatttctc ccaaatttcc attgctgctt 2544421 gactccaagt gacaacttga ttgatcttat cttgattctc tctaactgat gccgatacag 2544481 accctgccgc ttgtttcatg gatgtattga actgctgtac agaagctccc actccttgaa 2544541 cagcatgaac gaccgtgttc agcttttctg atttttcctg aatatcttca gccaggcggt 2544601 tggtcttatg taaaagctcg gctgtttcag ttgtgatgcc cttcatttgt ccctccagcc 2544661 cttcaagagt ggatgcgacg ttttttagtg tcagctgcag tgacttcaat gttttagaca 2544721 agtagatcac taatacgaga aatgcaactg cgatgagtgc aacgctcaaa taaagaataa 2544781 taatcatctc aaacctcctt gctgcaggat atactgctgt ttacccgttt tcttcaatca 2544841 taaacatgtg tactgggctg tatacatact attctccgtt atgtaagaaa atcctttaat 2544901 aagctttccc atcagataaa taaaaagcag tgagatcact gctttttatt atgccatgac 2544961 gttttcgtag gctctcatat atttttggat atctcctgct cccatgaaga tgagaacggc 2545021 tttatcatga gcttttaaaa cagatgtgtc atcttcttca atcagcttgg cattatgaat 2545081 ttttccctgg agatcaccga tcgtcagctt tccggcattc tcacgggctg agccgaaaat 2545141 atcgcataaa tacacacagt cggcgccgct caggctttct gcaaattcgt caaggaactg 2545201 ctgcgtccgg gtaaatgtat gaggctggaa taccgcgaca atttcccgat caggatactt 2545261 ctgtcttgcc gcctcgattg tcacttttat ttctgtcgga tgatgggcat agtcatcaat 2545321 cagcacttga tccccaagct gcttctcatt gaatctgcgt ttgacgcccc caaaggattt 2545381 gagagcatgc ttaatgatgc tggaatcaat ttcttcataa tggcataacg caatgaccgc 2545441 caatgagttt aatacattgt ggtggccgta cgcaggaata taaaacgtat catagaacgt 2545501 attgcggaca aagacatcaa aagttgtccc ttccgtgctt tttacgatgt ttctggcttg 2545561 aaaatcattt tcttcccccg tgccataata cacaaccggg acgttcgcat ggattttcgg 2545621 cagatgctca tcgtctccgc aggcaataat gcctttgttg acttgaagag ccatctcttg 2545681 gaaagcgtca aatacatcgt caatgcttga gaagtaatca gggtgatcaa aatcaatatt 2545741 cgtcataatc gcataatctg gctgatagct taagaaatgg cggcggtatt cgcacgcttc 2545801 aaacacaaag tattcgctgt tttcatttcc ctggcctgtt ccgtctccga ttaagaaaga 2545861 cgtcggtttt gcgttttgga tcacgtgagc cagcagaccc gtagtcgacg ttttgccgtg 2545921 tgcgcccgta acggcaacac tcgtgaattt tttcatgtag tcgcctaaaa acttatgata 2545981 acgtatcacc ggaattccct cagacatcgc tttttctatt tcaggatgcg tgtctgggaa 2546041 tgcgtttccg gcgatgactg tcatgccggg tttaatattt tccgcgctaa aaggaagaat 2546101 cgtaatattt cttttttcaa gcgctgtttg cgtaaaaata aatttttcga tatccgatcc 2546161 ttggacagta tatccattat catgaagtat ttgggcaagc ggactcatac cggtcccttt 2546221 tattccaaca aaatgataaa cagtcataat tgtacctcca acaaacgtct atctgttccc 2546281 cagtatatga cgctcatttc aatttgcgac cgcggcggct gaaaagcctc ccttagcggc 2546341 gtattttata tgttttgtta tgtttagtat caggttattt ctttccgatt aaacccagat 2546401 atcaagattt gtctatgcac agctgctgta aagcggcata gctgttaaat gctctaaaca 2546461 ctatcatacc atgtttggtg tgaaaatgaa cccatattat tcgtttatta aatcacttgc 2546521 tgtgatcagc acctctcgag gcttgcttcc ttttgcctca gagatcatgc cttccgcttc 2546581 catcatgtcg atcagccttg ccgcacgatt gtaaccgatt ctgaatcttc tttgcaggct 2546641 tgaagtgctc gcactgtttt gctctacaac aaactcacac gcttcgtaaa acagttcgtc 2546701 ctcttctttc agggcagatc cttgtcttac gagctcttct tgttcaaata aataggtcgg 2546761 cggcatttgg cttctgacgt gggaaacgac gcggtcgatt tcccggtctg acacaaagtt 2546821 accttgcaga cgaaccggtt ttcccgagcc gttttccaaa aagagcatat ccccttttcc 2546881 gagaagcttt tctgcaccgg ctatatcaat aattgttcgg gaatcaacct ggcttgagac 2546941 agaaaaggcg attctcgttg ggatattcgc cttaatcaga cctgtaatga catcgactga 2547001 cggacgctga gttgcgacga gaagatggat accgcacgct ctggcttttt gggcgatccg 2547061 cgcaatgctt tcttccacat cgtttggagc caccatcatc aaatctgcaa gctcatcaat 2547121 aatgacaact aaatacggca gcttttcacc catttggtgt tcagcggtta attgattaaa 2547181 gcggtcaatg tcgcggacac ctgaatgggc aaaaagctca tagcggcgct ccatttcctc 2547241 aacgacccat ttcaaagcag ccgtagccgc tttagcatca gtaatgaccg ggctgacgag 2547301 gtgaggaatt ttattgtaag gggccagctc taccattttc ggatcaatca gcagcacctt 2547361 tacctcactc gggtcagctt tataaagcag gcttactaat attgtattga tgcatacgct 2547421 ttttccggag cctgtagcgc cggcaatcaa gccatgcggc attttcttca agtcgataac 2547481 aacaggattt cccgaaatat ctaatcccag cgcagctgtg agcggtgact tgcttgtcct 2547541 gaaagctgag ctgcgaatca tttggcgcaa atcaaccacc ttgctcgtgc ggttcggcac 2547601 ttcaattccg atcgtgtttt tccccggaat cggcgcttca atccgaatat ctttagctga 2547661 gagactgagt ttaatatcat cggacaagtt ggtgatttta ttcaccttta cacccggttc 2547721 aggatgcact tcaaatctcg tgacagacgg accctgggtt acatggacca cattggcgcg 2547781 gacattgaaa tttttcaagg tcaaatcaag aagctgacgc tgttcttcga tccacgcagt 2547841 atcatcttga acctgcgctg gcgggacatc aagcagtgca acattcggaa atacatagct 2547901 gccgcggcgc tcctctgctt tttgctgttt atgcgtatct cttttcagca tcatcacatt 2547961 aaaaggaacg gatggccctt tttgagaaga tgcgctttgt tcagtccttt tctcctgtac 2548021 accaggcctt tttttcggct cttctgaagc ttcgcgaggt ttgtctgcgc gaatttcctg 2548081 ccggttttca agagttgcag tagacgattt ggaaccctgc tccatgtgtt cagttttctc 2548141 aagctctgta tggctgtctg gctgaacatc tatcttcgtt tcctgagcct ctcccagggt 2548201 gtcataatga ttatttatta tgctttctga tggctcttct gattcttttg ccacagtttc 2548261 tgcttgagcc agagcctctg atgaatactc atgatcagta aataaaggct cttcctgacg 2548321 aatgtccatt tgttcttctt gaacgaacgg ggactcagca ccttctgccg cgttttcatg 2548381 atgattgtat actgggctgt ctgacggctc ttttgctttt tcatcctcag atactgcctc 2548441 tgtctgagat tcaggagctg tttgctcttc atcaagttca gcggagaaaa caggctcttc 2548501 aaatttctct ggctgctgct ccctttgttc ttcctcagcc gttgcaggct cttcgcggcc 2548561 tacttcactg tctgaaagcc cttcagccgc cgtatctgtg agcatctcag gcggtgtttg 2548621 ctcttcggct tgttcagctg ggaagaaagg ctcctctttt tccggctgtt gaacgcctga 2548681 ctcaaatggc actttgttac ctgacggctc ggctggccgt ttcgccagcg cctcatcatg 2548741 ctccgtatcc tttctgttta aaacgccaga aggctgtttt tcaaattggg tatccgggaa 2548801 gaaaggactt tctattttgg aatgcgcctg tgtgtctgaa gcaggatagc cgcgttcacg 2548861 ttcgatctct tctgacagca gtgttacctt ctcttttacc gatttatccg gttcgttcaa 2548921 tgtttcagaa ggctttttcg gcacatcctt tttaacagat ggtttttgat tgaatccata 2548981 gacaggcgaa gggatatttg tcggtttaaa cggtttcttc gccggctctg ctgcttgata 2549041 tgtatgctgc tcttcttcat ttctgggacg ctctctgtaa ggtgcagcac ttggacgagg 2549101 cgcggatttc ggttcgtccg atggtgtgcg gcgccttctc aggtcatgat ttttgtatcc 2549161 gtcaggcacg actggaaaac ggaatttgcc ttttggatat tcataatata ttttaggatc 2549221 ttccaatctt tttaattgtc cttcaggatg atgtacttct tgttgctgcg gaatttgagc 2549281 gggttttgtc tcccgttcag catcctcttc gctttcgcct aaaaacaaat caaaaaattt 2549341 atgaagccaa ctcataattt atctctaact cccttatagt tttctgggac ggtttttagt 2549401 ataccactgc tggtcggccc agaaaagatt aagctatcag cagaaacaaa gccgctaaac 2549461 aagggcttag cggcttttca catgattcgt tttttttggc ggatttatgg gagtctaaaa 2549521 ctgaaatgcg tctcccgcct catagtctcc ttctaacaca aggattcctt tttcagcagg 2549581 ggcatccggc aaatcaagct ctttcgctga gcagatcatc ccgcttgacg gaacgccacg 2549641 aagctctgca tccttaatga caagtccgct aggcatcaca gcaccgactt tggcaacgac 2549701 aactttttgg ccttggtcaa cgttaggcgc gccgcagacg atctgaagcg tttcttctcc 2549761 tacgttgact ttacatacgc ttaatttatc cgcattcgga tgtttttctt ttgattctac 2549821 ataacccaca acaaacttcg gagataaatc aacgactaat gtttcttcaa cgccgtttct 2549881 gtttaaaatc tcattcacat cttgcacgaa tgtttctgag agcgcaacag ggccgttttc 2549941 atcaatggtc aagtaagaag acgcattgaa aatgttgaag cccgttgttt cttttgtttc 2550001 gttattgaaa attttgacga cgtcgccgtg tttttcatag cctaattgtt cgcgtgtcac 2550061 atcttgaaga gagatcagga gcgtgtctcc cacaccttct ttattataaa aagcgttcat 2550121 aagtaaaaat cctttctaat cctttttcgg acggcttttc gccaggataa acaccggttc 2550181 cagctttcct tcattgtaca aaaatgatag ggcggtaatc gggacggtgc cgcctgcaaa 2550241 gaagctcatc gacatttgtc ctagaatatc ataccccgat tcattccgga tgtcagcaag 2550301 aatcaaaacg tcctgatgag gaacagagat cgccagctca ccttctgcat gctgcttata 2550361 ctcatttaag atcgcttcgt tcaaaatccg gcttgcgtcg tatccgtcgt ttgccctgaa 2550421 gaaataaaag taattgccgg caaccgtatc ctctttgaca accgtcggca gggaacggag 2550481 attaaatgcg gccgtctctc tgatccgctc ttttgtccag ttttctttct caagcatgcg 2550541 ctggtcaatt aaacggtagg ttttcccgag atctagcgcg taataaattc ttgtctctgc 2550601 ggtatgatcg tcataaatga gcgggatatc ttcgctggac ttgtccggga aggaagtcga 2550661 gcggatgacc ggataaatgc gagtttcttt cccggtcatt tcctgagcct tcccttccat 2550721 tgccgtcatc gcttcggaga catagtacac gatctcatca atggcttcgt cttttttcag 2550781 ttcccatttt gcaataatcg gcggcaaatc gagtgtaatc ccttttttag tcgtttgatc 2550841 ctcaacacgg agggtgtctt tttctctgtc aaacagaaag gagcgattct cgtgctgaag 2550901 gcgctgcttc agtatatctg acagcttcct tgaggtcatt ttcaaaccga tgtcctcctt 2550961 tacgctttag cgagagagtc tgttaaaaac tgttcaattt cttcttttgt tttgcggtct 2551021 ttgctcacaa aacgatttac ttcttttcct tcattaaaca ccacaaagct tgggattccg 2551081 taaatttccc actctgcaca tgtatcaatg aatttgtcac ggtctacgta gtagtaggtg 2551141 aattcaggga aattcgcttc cagttcaggc aggaaaggct ctacaaaacg gcaatccggg 2551201 caccaatcgg ccgaaaacat aaatacagac caatcatcct ttaccgcttt ttccagctct 2551261 tgagttgatt caattttttt catttcatat ccctccagtt gtttatgttc ttacatgttt 2551321 tttatcgata ctcgtccatt tggatcatac caaactgctt gaggcaaaac cacttatatg 2551381 caacgaatga atatgtaaga ttggctttcc cattatcatt atcatatttt atttgcatta 2551441 tcaagctcgt ttcgtttaac atcgtgtaca tgagggtgaa atttacagat ggatatacat 2551501 aaggagggat ttttattatg gagtttatcg tctatttagc aggagaaatc cacagcaatt 2551561 ggcgcgagga aattaaagaa aaaacaaaat cactgaagct cccgattacg tttgttggcc 2551621 cgatggagaa tcatgaccgc tcagacaata ttggtgaaga aattatgggc gtacagccaa 2551681 atgccgtttt aaaggatgac aaagcctctg acatcaacaa cttcagaacc gccgtcctga 2551741 tgaataaagc agactttgtg atcgccctgt ttggcgaaaa gtacaaacag tggaacacgg 2551801 caatggatgc atcatatgcg atcgcaaaag gaaaacccct gattatcatc cggccggaat 2551861 cgctccacca tcctttaaaa gagctttcca ataaagcgaa tattacggtt gaaaccgtta 2551921 accaagccat taaggccctt tcctatctat ttgaaacaga ataagaaaaa agcttgtcga 2551981 tccgggctta ctgctcgttc aacaagcttt tatgaaacct acatattttc tttaatcgca 2552041 tccactgtct gcttatcgca ggctgttaca agtttgatga gcatttcttt agcagcagca 2552101 taatcatcaa tatgaatgat agtagcgttt gtatgaatat agcgggaaca tattccgata 2552161 accgctgacg gcacaccgct gttcgaaata tgaaccttgc ctgcgtctgt tcccccgccg 2552221 gatacaaaat attgatatgg aatatcatgc gtttcagcca tatcaagaac gaattccctc 2552281 attccgcgat gcatgactgt cgttctgtca agaatgcgca gcaaaaagcc ttttccaagc 2552341 tggccgaatt catttttgtc tccgctcata tcgtttgccg ggctggcgtc aagggcgaaa 2552401 aacaagtccg gtttaatcat atgagaagcc gtctgcgcgc cccttagccc tacttcttcc 2552461 tgaaccgttg cacccgcata gagtgtattc ggaagctctt taccgtgtaa ttccttcaga 2552521 agttcaatgc ttaagccgca tccatatctg ttatcccatg cttttgataa aattttcttt 2552581 tcattcgcca tcgtcgtaaa cggacaaaca ggcacgatct gctgtcccgg tctaatgccg 2552641 attttgatgg cgtcttcctt atcatccgct ccaatgtcga tcatcatgtt tttgatatcc 2552701 atcggtcggt ttcgctgcgc atctgtcaat aaatgcggcg gtatgcttga aatcacaccc 2552761 ggaaccggcc cgttatctgt ttgaatttca acccgctgcg caagcaaaac ttggctccac 2552821 cagcctccga gcgtctggaa tctgagcagc ccgttgtctg taatggatgt caccatgaag 2552881 ccgacttcgt ccatgtgccc ggctaccata attctcggtg cgtcctctgc gcctcgtctg 2552941 actccgaaaa cacttcccag tctgtcctga acgatgtcat ctgcatattt ggctagctcc 2553001 tgcttcataa aagcacgaac ctgatgctca ttgcccggcg cgccgggaag ctgcgtcagt 2553061 gtttggaaaa gcgctttcgt ttcttgattc atgttttccc ctcatttcta tgtagtcctt 2553121 ttattttatt agaaacaatg aagttttcca agcactctga cccaatctgc tcgatcagcc 2553181 gcgtattgct taacaggatt tggctgtttc tgtataatga aaagtacgat caaccaggag 2553241 gtgctttatt ttgaaattgc gtcatcttct tttaggagca ggacttggaa tttgtacggc 2553301 tgtcgttgtg agacaatatg tgatgaagcc ttatatttct tcagaaaaag cgcttcgaat 2553361 tgtaaaatct gcttttaagc agcggggccc gattgacgga tcatggattt acacccagcc 2553421 ggagccctac aatattaacg gagaaacggt acaggtatac aaaaccggca ttacacgatc 2553481 agctttcgga gaattagaac agtatgaagt catggtggat gcgaaaacgg gagaaattgt 2553541 tgatgtcatt gatacaatcg cctcttaaca ccggacaagc aaaaaataga agccgctgcc 2553601 tatgcagcgg ctctttttta ttatatcgcg cgaatcggtt tgtataccgg ataccacatc 2553661 gcatcctgca ctgcctgtat aatgtcttca ggctcttccg tagcgacgcc ttccttcatt 2553721 gcggtttttg caacttcaac agcaacggtt gccgaaacag tgcgcaaatc ttcaactttt 2553781 ggaagcatcg gcgccccagg caccccgaca ttgaccatac ctgcgattgc ccgggcacat 2553841 gcttcaaaca tgccgtcggt aattaatttt gattttgtaa caatcgttcc aagaccgaga 2553901 ccagggaaga caagcgcgtt gtttgcctgc ccgatatgat acgtaactcc gttatattca 2553961 actggcggga acgggcttcc tgtcgtgatc agcgcacggc cttctgtcca ttcgattaaa 2554021 tcctccggct ttgcttcaga aagagttgtc ggatttgaca ttggcaaaat cgccggccgt 2554081 ttcacatgtg acgccatttc ttttacaatt tcttcagtga aagcgccgga aaccgtagat 2554141 gtgccgatca ggatcgtcgg tttcgcctgc cgaaccactt caagaagatc aatgcctccg 2554201 ccgtctccgt tccgctgata atccttcact tcatcagccg aacgggcata cggcttttgg 2554261 aaatcaagaa gctgatccat atcatctgtt aacagcccgt tcctgtctat gcaccagaag 2554321 cgcttgtatg attcttcttc actcagtccc tcgcgcacca atgcttcccg cagctgttcg 2554381 gcaattccga ttcctgccgt tcccgctccg aatataacaa ctctgtgatc tctcagcgga 2554441 actttagacg cttttgcaca ggataagact gcggccaaag aaacagcgcc agttccttgg 2554501 atatcatcat tgaaggtaca cactttatct ttatagcgtt tcaaaatgct tcgcgcgttt 2554561 ttcgccccga aatcctccca atgcagcaat gcattcggaa atgtttctct cgccagcgca 2554621 acgtagtcgt caataaattg gtcataacgt tccccgcgca ctctggaatg ctggttgccg 2554681 acataaagcg ggtcgttcaa gaggctctcc tgatttgtcc ccgcatctaa aacaacagcc 2554741 agcactctgc tcggatcaat gcccgcagcc gctgtataaa ccgccagctt gccaatagaa 2554801 attgcgattc ctccgacgcc ccagtcaccg attcctaaaa ttccttccgc atcagttgca 2554861 acaattaaat cgatcgtatc gctttgatct ttatactgtt taaaagcttc tttcataccg 2554921 tccgggtcat cgattgacag atagagccct cgtggttttc tgtattcatg gctgtatctc 2554981 tgaattgccg ttccgactgt cggtgtgtag acaatcggga gcatttcccc taaatggtca 2555041 tttaacaggc ggtaaaacag cgtttcattc cgatcgtgca gcgccgttaa atagacattt 2555101 ttgctcaaat cgtcaggctg tgcggaatat tgttcatacg ctcttttcgc ctgatcatca 2555161 attgttaata ccttgggcgg cagaaagcct tttaaaccaa gttcttttct ttcttcctca 2555221 gtaaaagcaa cacctttgtt caaaaaagga acagagagca cttcaaggcc tcttaatgtt 2555281 gtttgaatgt ctccttcgtt tgttactctg aattgtttca ccctgcctct tcctttctga 2555341 gcataatagt actaggtttg cattattagc cggaaaacat gcagggtaaa cataaaaata 2555401 tgctatcgct tcattcgctt aactgacttt ttgatgcttc cgtcctcctc ccattgaagg 2555461 gcgcgatact cggcatcatg gtaaaaaata aaccaagcat ctttttctgc tgcgaacgcc 2555521 tgccatttct gcttttgcgg gatagaggtc atcggataat catcgtaagc cagcacccat 2555581 agcggattgc ggtgggcatg tgtcggcatc agatctgcca tatgtacggc agtttcaccc 2555641 gcatcctcgc atatcaggac actgtgtccg tcgctatggc ctccggtgtg atgcattgta 2555701 ataccctctg tgatcgttaa ggtgtcttca aaggttttga cttggccagc tacagcctcc 2555761 caattttctt tccaatacgt atttttcgac ctgatattcg gatggcgcat ttcgtcccat 2555821 tcaacagctg atgtataaat cactgcattc ggaaagacag agacgagccg ttcaccttca 2555881 tattccgtta aaccgcatgc atgatcaaaa tgaaggtgtg tcattgcgat cacatctata 2555941 tcggcaaccg ttaatccgag tgcagctaat gagggtttca cattcgactc ttgtgtcacg 2556001 ccatagtttc gtttttgttt atcagtcagc ttgccgtacc caattccggc gtcaatgatg 2556061 atattgagcc catccttttg aatcaaaata gggtctgttc ttagttcaat ctggtttttt 2556121 tcattgactg gatatttttt agaccaaagc ggctttggca caacgccgaa catggcgcct 2556181 ccgtccatat gcgtcacgcc tccgtcaagc caggtcaacg tgatgtttcc aattttcatt 2556241 gtttccattt tcaccccccc ctatcatcat ggtagcaaac ggcccataaa aaaaacagac 2556301 tcctgtcaga gtctgtcttt acgttctcca ttcaacctca gcccgataga tcggctggcc 2556361 gagtgcagag aatttttctt catattctgt cataatattg ccttccagat tgctgttatg 2556421 caaatcgaga ctgacgtatg tcagcaggag gccgtactca gagaagctct tcaaagagta 2556481 ctcaaataaa cctcggttgt ccgttttaaa atgaatcgat ccgcctttgc ccattacttc 2556541 ttcatatttt ttgaggaagt gggaatatgt caggcggcgt ttttcatgcc gtttcttcgg 2556601 ccaaggatca gaaaagttca agtagacccg tttcacttcc cccggctcaa acacatccgt 2556661 cagcgtgtcc gcatctatat tcagaagctt tacattctgc gcttcgctgt cttttacttt 2556721 ttggacggct gtcacgatga cgcttttaaa taactcaata ccaatataat tgatgtcggg 2556781 attttgtttg gccataccag aaataaattg gccttttcct gtaccaacct cgatatggat 2556841 cggattgtcg ttgccaaaca ctgtgttcca tttcccttta taatcagcag gattgctgat 2556901 ggcaatatct gcgttttcag ccaaaaagtc atcagcccaa ggcttgtggc gcattctcat 2556961 atgattgaca cctctatcta ttatttcgac taacaacata ccatgaatta aaaagacccg 2557021 caagctcgtt tttccagtgt atctctctta aggccgagcg cataaaaaaa gagggtcccg 2557081 tctgctggaa cactcctttc ccatgtataa aaacgctctg ttttgaacaa tttaacccgt 2557141 atgatactga agggatgtgt accgttatgg gtttacatta tgagcatcaa gttcatttat 2557201 tgaaggatat attgactgac catcaattgg actgctgcgg aacagtcgca gagtacgagc 2557261 agcttgagcg tgtgattaaa tcactgatgg caaacaccga gcttgattca aatttcaaaa 2557321 acgtgcttga agatgtttac cgctacagcc aatcaggaat atcgtccaaa tccatcgact 2557381 cacacataca agagcatcag aacagcctgt ctcaatgggt agagcaaatg gattcgtatt 2557441 cctgattaat caacaattcg tttcatgagg atatgcagct cttccattgc atcatgaaat 2557501 tccttatcat tgccttttgc tttatgccag gcaatgaaag taattgtttc agataacaca 2557561 taccaagcca ttcgcaaccg aaggctttct gtcagctcta tgccgtacat gctcagccag 2557621 ctctcccaag ctggcttttc gacgtagtgg tacagcaaag gcccgaggtc catcgccgga 2557681 tcagcgatca tggcgccgtc ccagtcaatt aaatacagct ggttgtcttc agacaatagc 2557741 cagttattat gattgacatc acaatggcaa acgactttct caccgaaatg cacttcatgc 2557801 aggtgttctt ccaaatactt gatcccttct tgaatcagcg gcgaagattg ctgcacagca 2557861 aatacagcct gcttcagctg agacaaaaga gcccccgggt tcagcggttc ttttccaagt 2557921 ctcttcagca tgtccagcaa ggcttttgat gtgtgtattt tacgaagcaa ttcagcaacg 2557981 ggccgtccgc tcatgtcttt aggcttcagc tctctgccgg tcatccagtg ctgggccgta 2558041 atgacgtccc cattttccat ccgttttgtc caaaccagct tcggaacaat gccttcggcg 2558101 gataaaacag ctaaaaaagg tgagctatta cgttttaaaa aaagctgctg cccgttatgt 2558161 ttcgcataat atgcatctcc tgtagctcct ccggcgggga agatctccca atcgctacct 2558221 agtaattgtc ccaaccagtt catatcaatg ttcaacccat catttcttaa aatattttag 2558281 aattaaggct aatcgtttct agtctatcca gcgaatgcct ttttcgtacg aatcgtataa 2558341 aaataaaaaa gacagctatt gagagtctca tatgctaatc aatagccgtc ctttaaattt 2558401 tagcgctata gcacaaactt cgtcaagcaa aactcttaag atctgatgct aaatataaga 2558461 taaccgttcc gatgccgttt actgcaaccg ttttcttgat ttctgttggg tcttcctgaa 2558521 atcctgatgg atcacataaa agccgataag gtatgtcgtt tggcagcctc cactcgacgg 2558581 agtctggact cgcgtgatgg ataacaatga tatctttcca ttcgtcaacc tcgtcaagat 2558641 cataaagcct gtatgcgata aggtgttctt ttagcgtcaa gcattcaaga tggcgctgga 2558701 tgtctgcagc ggacctaaga cggaatgcag gatgcgcttt tctcagcgag atcagcctgc 2558761 ggatatagtg aacatcttct ttgaatgttt cacggcgatc ccagtcgagc tggttgatgc 2558821 tgtcactgga ttgatagctg ttttccactc cctgcttcgt ccggaaaaat tcctggccgc 2558881 tgtgaataaa cggcacccct tgggcaagca aaataatcgc ggctgcaagc ctttgcctgc 2558941 ttcgctttcg gctgtcattt tcttgaggaa gcgcaaagct cattttatcc caaaaggtgt 2559001 gattgtcgtg tgattcgaca taattgatgg actggcttgg ttccggaaca atcggtgcta 2559061 atgccttcca tccggaagac ccggcaattc catgcatcac agcttgtgct gattcaccgt 2559121 tgccgagcgc aaaccctgtt gccttaaggt gaaaggtgtt cccttttaca gcgtcacgaa 2559181 acatatcatt aaaaaagccg atgcccggca ttcttggcgc gttcgccaaa gcagctttct 2559241 gttcatgcgg cagcggtgta gccaggtccc acccttctcc aaaaagcagg attccgggct 2559301 ttgccttagt tgctttctct ttcatataaa gcacggtgtc aatatctaaa atcccgagga 2559361 gatcaaagcg gaagccgtca acattgtatt cttcaagcca atagaccacg caatccgcaa 2559421 tgaattttct tgccatcctt ctttctgatg caatatcatt gccaacgccg gtgccgtttg 2559481 atggcatccc acattcgtcg tgccggaaaa aataaccggg cactgtcttt tcaaaggggg 2559541 aattctccct cttatacaca tggttaaaaa caacatccag aatgactcgc agaccgtgct 2559601 gatgcagggt attgatcatt tgtttcagct ctgtttttct cgtttgagga tcatgaggat 2559661 ttgaggcata gcttccctcc ggggcaaaga aatgaagcgg gttatatccc caattgtatg 2559721 catcaagcgg cttctcttca tcaactccgg caaaatcatt caccggcaga agctccacat 2559781 gtgtcacacc aagctctttt acatacgcta atcccgaaga actgccattt gcggtttgtg 2559841 tatcagtttc cgtcagcgct aagtattttc ccttgtttat catgccgctg ttttcatgga 2559901 tggagaagtc gcgaagatgc gtctcataga tgacggcatc cacagggtgt gagaatggtt 2559961 taagaggagc agtccatttc atttgatccg ggcgcaagac gacgcccttc tctccattta 2560021 cagtcacagc cttggcatac tggtcaactg tttccatcca ttctgaattg ttgcagatgc 2560081 aaaacaaata ctcatatccg tgaaggtcac ctgtgaccgt gacggcatag acgccttttt 2560141 ccaagcgagt catttggaat gtgcgcccgc ttttattggg gtgtgaaagc ttgacagcag 2560201 ctgaggttgc agcaggcgcc catactttaa atacggtatg atccgcggta taaacggcgc 2560261 ccagctctcc gtcataataa aattcgtcat caaacgctgc cgtccggatg accgcgccaa 2560321 tttggagatc cgttttgtgg ccgctggatg ctctgacgca atggattttt ccaaatgtca 2560381 caggatggtc ggatacgcag acgtacttgt attttgcttc aagggagtat tcctccctga 2560441 cagccagagg aaaatctgtt atttctgtct caagccgaaa cggcggtgtc atgatttcct 2560501 tttgttcagc aggaatcaga acagtaatga tattcatgtc atcgacatac gcttcgaagc 2560561 tgcggcggat gctgaccatc ggaagctctc tcctccaaac acgtttatgt tttgattctt 2560621 aggggtgaag gactagatgc cagacgaaac ggggtagtgc ccatgatttc tccgtcagca 2560681 tggaacggga ttttgtcctt cgtgtaaaat gtaatgtcct tcgctttaaa catcgtaacg 2560741 ccatccatct ttgtatgttt tccaaatgcc atgagacata aaagccaata ttttttcaaa 2560801 aacggctggt tttcaacgat tacgatatca aatgtcttct cgcgcggatt tgctaggggc 2560861 gccgccttca tgcctccccc gtaaaacgga tggttggata caacggcaaa ccagacatca 2560921 tgaaattcgc gcgtctcgtc ttccgtcgta caagctaatg taaacggctt aaaggttgcc 2560981 gaagcgtgca aatgagaaag cggatacaca agaaatcgaa ggcggagaaa aagaaaaacc 2561041 cgtctcaacg gaaattccat cgccttttta ttgacatatg cgtcaaaccc gatcccgata 2561101 tgattcataa aataaagaat ctgtgattta tcctgaagga aattgacgct ccctaaatga 2561161 aaggttcttg ttaacgggcg ctttaccttc ttgatttcct gtatcagatc gattttttta 2561221 atagagaacc ctcgcgaaaa atcattatac gcgcccgccg gcacaaagct cagctcaata 2561281 tcgtcaacat ctttcagccc gttgacaact tcatgcatgg ttccgtctcc gccaatgacg 2561341 atcaggcgct tcagcttata ttcctgtatc gttgaaatct gtctggcgag cacctcggcg 2561401 tgtcccggat gttcagttaa aaatgaacgg tgctcaacct ttcgtttgat caattctttt 2561461 tgaatggact tccaaacacg caggccgttt cgatgtcctg ctgtcggatt aataataaaa 2561521 aaccaatggc tcatctttct cacctgctta tgttatgaga aaaccgctca aatcgttctc 2561581 ttttactcca gccactcctg tctgcgatag gagtcagaca tgcagtaaga caatagagcc 2561641 tttgcagcct ttacctgatg atgtttgatc ggagcagtgt ttttcttctg ccgctcaatc 2561701 cattcttccg cgctccgctt atccgctatt tctaagccgt atggcggctc cgggtaatcg 2561761 atgtacgacg ttctgctcag aagcaatttt cgaaccggaa tctcagcctg tttttccttt 2561821 acgatctttg acacaaccga gtccgtacga aacaggctaa gccctggatt taacactgat 2561881 gcagtctgag aggctgtttt cttgtcccaa aaacgatttt tagaccctat gtagacactg 2561941 tcttcctcag cctctaaaaa agaaacgcaa taaatttcca gaggagaaat aatcacaatg 2562001 cttaattcaa ccgccgcctg ctgaattttc agcacaggct tatacataat aaaataagaa 2562061 tcaggcagct gctgggtcag ataacgcaaa atgcggtcct gcttcacttg gtttgagagt 2562121 tgagatattt ctgaaagagt agagcttgcc catttgagct gaaaatcata taaatgcctt 2562181 ttataaaaag aagcaagcgc caccctgctc ttcgggagcc ttacatgaat atcttcttcg 2562241 tcctcaaacc attggtgtct ctcttcttgt atatcggctt ttatctcttc ttttcttctt 2562301 ttcaatgaaa atttttttcg tttctgcacc ggttccggtt cttcagcact ggcttgcctt 2562361 tcttcatgct ggcgctccgc tgcttctact agtgaaagcc agcgctcttt tttcaaacgt 2562421 acaaactggt tgatataatg gtacggatca agctcatatc tcgatatata atcatgaatt 2562481 ttgatgattt gtgccatgtt tgtttctcca ctccgcaatg aattaagata attgaaattt 2562541 gaatatttcc tcgtattttg gtgattggtt caagtgtatt tgaaagagcg aaaatcgttc 2562601 agccatcatc gaaacctcgc cgctttcaaa cggaacatga gctggaaatc catcttcgcc 2562661 tgtccatttt cttgccagcg tcatatgagg atgatacggt cttttttcca cttgaaagcc 2562721 ggcctgaagt acagcctgct tcgtatgttc ccgcagtcta tcaagcgttt tgtttttctt 2562781 tggctccaga tgtaaaacgc gcggctttct gcggtcgccg aatacatcta tcttgccaaa 2562841 cttaattgaa aatggatcaa tttctgaagc aatctctgct agcgaacctt caagcttctt 2562901 tatttgtgtc tcatccgccg ctccgagaaa aattaacgtg atatgatagt caagcgggtg 2562961 cacccatttt tgaaacgtca atatcggttc gtttttcgca gcctggtaga tcggatttgc 2563021 aattccctca ggtatgggaa cgccgatgaa ataatgaggc cgtatatctg gcatccgtct 2563081 gacactccct tctttgacag ctattatttt atcaataaag aggctgtgcg gatagaggaa 2563141 cagtgtatga aaacactctc gcacaaacgt ttattatgtt aggatattat atgacacttg 2563201 ttttattcag aaaggaatga caatgttgaa aatcgttgca aacacagctg atctgatagg 2563261 agatacaccg ctagtgagat tgaatcggct tcagccggaa aatgcggcac aagtctattt 2563321 aaagcttgaa tttttcaatc cgagcggcag tgtgaaagac agagccgctt atcaaatgat 2563381 catagaagct gaacaaaacg gtttactcaa gccgggatca gttattatag agccgacaag 2563441 cggaaatacc ggcatcgggc tcgccatgaa tgcggcagca cgcggatata aagcaatctt 2563501 agttatgcct gatacgatga cgaaggaacg gatcaaccta cttaaagctt acggtgcaga 2563561 ggttgtatta actcccggag aggaaagaat gccgggcagc atcaaaaaag cgaaggagct 2563621 tgccgaacaa attccgaaca gctatattcc aatgcagttc gataacactg ctaatcctga 2563681 tgcgcaccga aaaacaacag cgcctgaaat cgcccgggca atagaggaaa tcggaaaacc 2563741 gctcggcgct tttgtagcct cctctggaac gggcggaacc attaccggaa caggtgaggc 2563801 gctcaaagag ctttttccgg atatcacggt tcatgttgtt gagccagcgg gttcgcctgt 2563861 attatccggc ggaaaacctg gcgcgcataa acttgtagga acgagcccag gctttatacc 2563921 gccgatttta aatgaagacg tttatgatga aattatcaaa atctctgatg aagacgcgta 2563981 tacgacgaca agacggcttg ctgctgaaga aggaattctt gtcggtcctt catcaggcgc 2564041 tgcctgcttc gcggcaatcg aaacagcgaa acgcctctct cctgacaaag ttgtggtctg 2564101 catgacagct gatacaggag aacggtactt atcaactgat ttatggtcat ttatttaaaa 2564161 aaaggactgg cttcagcaga agccggtcct tttattttgc aagctcgtaa atggcctgag 2564221 catataacgc tgtcgatctc agcaggtcat caatttcgat atattcatcc ttttggtgtg 2564281 cgctgtcagg gcgtccgggg aacagcgggc cgaacgcgac accggctttt aaggatctcg 2564341 cataagtccc cccgccgatt gagattaaat cagctttttt acccagctgg ccttcataaa 2564401 ccttttgcag ggttttgact aacggatgat ctgcggacac gtgatgcggc ttgctgtctt 2564461 tgaattctcc cagctcaaat tcagatgcgc tttcgaatgt atcgcggatc actttgcttt 2564521 ctgctgtcac aggatagcgg atattgatcc cgagctcgcc tccttgccct tctttatagc 2564581 gcagtgttcc gacatttaat gtcagctctc cgctgatttc atcctcacag tcgatgtcca 2564641 gtttttttcc tcttgtatca cctgagaact tatctgtcac aacttgcaca aaccgctttc 2564701 ctgcatcgtc aagctcagtc tgctggagaa attcgcacaa taaaatgccg gcattgatcc 2564761 cattgttcgg ttccatcgca tggcaggaaa gaccgtacat acgcaaaatg agctgtccgt 2564821 tctctattgc agcttcccct ttttggtccg tcgtgcggag catgtcttta aatgaagaca 2564881 gaatctcttc atttttcggc ccttcaatga cagcttccgc agcgtcgggc accatgttta 2564941 agcgaaggcc tgattgaaac gagacaagca ctgcctttgg ttcagcttga tttgggcggt 2565001 gcggaataag taaagaagca tcgatgatcc ctttttccgc attaatgatc ggaaaatcgg 2565061 cgtcaggcgc aaagcccatt gttggcattt cttcatgctt gaaataatgc tctacgcatc 2565121 tccaatcact ttcttcatct gttccgataa tcattctgac tcgcttggac aggggcaaat 2565181 tcatgtcttt cacgattttc agcgcgtaga atgccgccat tgtcgggcct ttgtcatcaa 2565241 tggcgcccct tgcataaatc cgtccgttgc ggatttcagc tgaaaatgga tcactcgtcc 2565301 acccatctcc cggcggcacg acgtcaacat ggcaaagtac gccgataatg tcatcgccct 2565361 ccccccattc aatatgacct gcgaagccgt caagattttt tgttgtaaag ccttcttttt 2565421 ctccaagctc cagcaatgaa gtcaggctgg catttacccc ttctccaaac ggtttaccgg 2565481 gtccggcggt tgtttcgtcc atgacactgt tgattctcaa aaattcctgt gtatcacgaa 2565541 ttaaatcctc tttttttctg atcacttcaa cttcccagtt cataatgatc ccctttccgc 2565601 aagaaatgac ttgcaaaaac caaataaaac gaataatatt aatggtgttt tgttaaaacg 2565661 ttcgtaattg gaggatacta tgtttcatct aaaagagcag caaacatcca taaagcaaga 2565721 aatcatagca gggctgacga cctttttcac aatggtctat atcgtcgtgg tcaatccggt 2565781 cattctggct aacgccgggg ttcctttcga ccaggttttc accgcaacga ttattgcctc 2565841 cattgtcgga acgctgtgga tggccctggc agcaaattat ccgattgcta ttgcgcccgg 2565901 catgggcttg aacgcttatt tagcctttca tgtcgtaagc gcaagcgatg gcggcatcac 2565961 gtacgcaaca gctttcagcg cagtatttac agcaggggtt ctcttcatta ttctatcgtt 2566021 aacgccttta agaaaacaac ttatagaagc gattccaaac aatttaaaat acgggatcac 2566081 aacagggatc gggctgttta ttgcttttat cggtttgcgt caagcgggaa ttgtggcagc 2566141 tgatgagtca aacctggtca ctctcggcaa tctgcattca cctggtgtta tcttaacgct 2566201 ggtcggcctt ttgatcagcg tggtcctgat ggtgctgaat gtaagcggcg ctttatttat 2566261 cggaatggca gctaccgctt tgatcgcctt tttcaccggt cagctccatt tttcaaaggg 2566321 atttatgtcg cttcctcatt tgccggaagg attgatgatc tcaaatccat ttaccgcttt 2566381 tggcgatgtc attcatcacg gcctgtacgc tgtcgtcttt tcttttctat tagtcaccat 2566441 ttttgatacg acaggcacga tgatcggagt tgccgagcaa gccgggctga tgaaaaacaa 2566501 caagctgccg aacgtgcgaa aagcgctgct tgctgattca accgcgacga cagtaggagc 2566561 tgttttcggc acaagtccga cgactgcatt tatcgagtct tccgccggtg tcgcagccgg 2566621 gggaagaacg gggcttacgg ctttgactgt cgcggtgatg tttgcggctt caatgttttt 2566681 cagtccgctt gtcagcgcct tgtcaggtat agccgccatc acctcgcctg ctttgattat 2566741 cgtcggcagc ctgatgatgg gctcagtttc caatatgaac tggaaagaga tggacgaggc 2566801 atttcctgcg tttctcgtca ttctagccat gcctttgacc tcgagcattt ctacaggaat 2566861 cgcgcttggc tttatttcgt acccaattgt aaaagcggcg cggggaaaat ggagagagat 2566921 tcatccgctc gtcatcgttt tcgccattct gtttttcatc cagctgttta ttttataagg 2566981 atagaccaaa aaacccaaac gtcgccgttt gggtttttta tgtaaacaat aaagagacag 2567041 cggccgctaa aaaacaacag gcggcaaacg catagtgcag gatgttgata cagctttttc 2567101 tggcccgata atattcatca ctttccttat cggtgccaat taaaaaaggg gcatccatga 2567161 ccttgtcaaa aataagcgtc aggatataac ggcaaacccc tgtgtatacc agcagcgcaa 2567221 tcaccttcag ccaaattggg gaaacaaata tgagaacagt gaaagctgac agtagcatgt 2567281 acatctgcct tgcatactcg ccattcctca gcataacttt aaaaaacaac tccttatagc 2567341 ctgtgcagat cgttcgtctt ttaaatatcc tttttgaatt tcggtataat aatggttttc 2567401 ttctcatcct gtcttttact tttggcattc ccgcctcctg actcatcatc atcacaagtc 2567461 ctgcaagggc aagcctgctt tttttctctt cagtcacctc agcttcaaaa gccgtgaacg 2567521 aggctgtctt tttcaaactg cggataactg agaaaaacaa aaataaaatg ccaaaaagcg 2567581 caagcaagtg ccgctcagta aaaacaatca ggatagcaga accagcaaaa agaatagctc 2567641 tgacaagggt atcgccaatc catctcgaaa tggagcgcgg ctttctgatc ctgtcttgct 2567701 ttaaggataa aaagaatata tgaaggccaa acaaataaca caatagagca gtgctttctg 2567761 cgaatgtgat gagaacagaa tgactgatca agggaaggac aatgaaaaag agaagcagcc 2567821 atttagccag cgtggccaga aaagaataca aaagcgcata ccgtttgagc tgatagatga 2567881 tttccttctt ttgcagcaaa aacactttgt ccgcttccat taaaaatgta cgaatcgaac 2567941 ctgtaaacat gatcagcaca cacacagcat acagccatct ccattccgcc acttcagacc 2568001 actcataaag aaggcctctt ccgttcatca aatcaatata ctgatagatg acaaaagcaa 2568061 tcgccggcaa aacgatatag agagcgactg tccagtcaat gaccgcatgc aacactttaa 2568121 actgatactt ataatagtca aacagccttc gaaaaaagag cgtacgcccg ttcatagccg 2568181 atcaccttga actgccttat aaaaacagtc aagcaatgac tgcccctcta atccggtctt 2568241 gtcctgaaca tcttttaacg tgccttggag aaataatgaa cctttctcaa tcatataaaa 2568301 ccggtcacag attttttccg cggtatcgag tacatgcgtg cacataagaa ttccggctcc 2568361 acgttctttt tcagccttaa gcatgtccac aaagcgtttc gtcgatatcg gatcaaggcc 2568421 gataaacggt tcatcaatca catacatatc cggcttagag agaaaggcct ggataagcat 2568481 tagtttttgc tgcatgccct tcgaaaaggt gacaggcagc tcatgtttga catgatctag 2568541 cgaaaacgtc tgcagcaggc tttgggcccg atgcgcaaat tcactctctt caatgccgtg 2568601 aagtgtgctg atcagatcca aatgctccca cagcgtcagt tcttcgtaga aggacggatg 2568661 ctccggaata tatgcaaatg aacagtcgtt ccaggcaata tgccctttaa aatcttctga 2568721 aaggccgagt atcgccttga ttgcggtgct ttttcctgcg ccgttagctc cgatcagtcc 2568781 aaccagttcc ccttttctga cttccagaaa aacatcggtg agcacttttt ttcggcttgt 2568841 atacccggcc tgttctattg aagcttcaag caaatttgtc aaaactcact cacctccaaa 2568901 atttactacg aaatagaata aaaaaagttt ctttaaccat aataatattg agccgaaata 2568961 catagtaatc caacaaggat ggctgcccaa cgcgaaattg gaaaaaatta ataggagtta 2569021 tccctagatt catcactgca atatcgtgta taatgagggc gaattatttt aacaattaca 2569081 gatgtctgcc tttgttgcta tttcgtacgc agttgatagt cgtgagttgt ggttagtcaa 2569141 gtccatccga tcttatgata gggagtggtt ttttgaaacc ttcaacaaac cgtatgctaa 2569201 ctcgaatcaa atcagtttac atgtttattc aagaaaaagg tcttgtgaca acacaggaac 2569261 tggttgacga attcggcatt acacctagaa cgattcaaag agacttaaat gtgttggcat 2569321 ataatgatct tgttcatagt ccaagccgtg gcaagtggga gacaacgaga aagaaagtaa 2569381 agattacctc ataaattgaa aattacatag ggccgcctga gagcggtccg atagataaca 2569441 gggcgaagaa actactgagc cttgtttttg tgtgcttata aataaaaccc cgcattcggt 2569501 atgcggggtt tttgtcatgc ttgcggctca tttagcaaat gaagctcttc ctctgtcagc 2569561 tcacggtatt ctccgggtgc cagagcggga tctagggaaa cgcgtcccat cgaaagccgc 2569621 ttcagataaa ccacttcatt gccgactgcc tttgccattt gcttgacctg atggtatttt 2569681 ccttctgtaa ttgtcagata tataacggta ttgccactgt cgtttgtttt gatttccgct 2569741 tttgccggct ttgttttata gccgccctct atgtagacac ccgtttccaa atcggaaatg 2569801 tcttcccgag aaatctgtga ttttaaatgg acttcatacg tttttggaac atgcttttta 2569861 ggagaaagga gccgatgtgc gagctggccg tcatttgtga gcagcaaaaa gccctctgta 2569921 tctttatcaa gcctgccggc tggaaatggc tcaaatctca tctcctccgg cgtcagcaga 2569981 tcgaccactg tttgctgccg gctgtcctca gtcgccgaca gcacgccctg cggtttattc 2570041 atcataagat aaatgaactc tcgataatca accggttccc cgtatacggt cacctcctgc 2570101 gtatcaggat caacgtgctc ctttacatct ttggcaggtt tgccgtcgat catcacggct 2570161 ccagccttca caacggcttt gacttctttt ctggaaccat acccgctgtt ggcaagcagc 2570221 ttatcaagtc tcattcccaa tctctccttt ataaaagaaa gcccgcagca tgcgagccct 2570281 cagtttcatc atatctagtt catcagcctg catgtctgcc tttcctaaag aaacctggca 2570341 aacggcggcc taaaattttc tgcaaaaatc ctaatcggta gccgcaatac aggtagacag 2570401 ctccgccaac agcggccgcg atcaccacaa caatcgcagc ttgcatctgg ccatcctgat 2570461 aggaaataaa gaagcctaat acccactgca cgattttcac ggcaataccc ataatggctg 2570521 ataagaccag catcaaaaca gttcgtttaa caagtatctt atacgaatag cctgcatggc 2570581 gcttaatcat gataaaccca tataaaaggg aagcgatata tccaagcgcc gtcgctaaaa 2570641 tcgctccgtc agcctgcatc agcttgatca gcggaacatt cagcacaagc ttgatcacga 2570701 caccgatcac aaggctgaca accgcaaatt tttgcttatt gatgccctgc agaatagctg 2570761 cgttgactgt aaacaaagag aacagaattg cgacaggcga ataccaaagc aaaatgtttg 2570821 cccccagttc aggatgaagg ctctctgacc cgtaaaagaa cgtatacgtc ggtcctgaca 2570881 atagagagat cccgacaaca gccggaataa ttaaaaacag gatcgtctgc atcgtttgat 2570941 taatctgctg atttaacagc ttatagtttc cgcttgtaaa cgattcagta atcgttggaa 2571001 ttaatgtcag tccaaaagca gttgctaggg aaaccgggat catcacgagc ttctgaacat 2571061 acagggttag aatcgcaagc atgtcctggc tgatggcttg atgaccggct tcaatcatcg 2571121 ctttgttaaa cgtatttgta tcaatatagt tatacaaagg gatggctagt ccgacaaaaa 2571181 cgtacggagc agcatagctg aacagctcga aaaacatttt cttgtagctt aggtttgctg 2571241 tcggacccgt attcggcatc atcgccagca ggctgccctt ccgtttgttc caataaatat 2571301 aaagcacgac cagccctccg aaggcaccga tcagcgctgc gaaggttgca tagcccacag 2571361 cgatgacaag gccgccgttg aaaaccttca aaatcaagaa tgtcgcactc aatagaaaga 2571421 tgatgcggac aatctgttca acgacttggg aaacagctgt cggacccatc atttggtgcc 2571481 cttgaaagaa tccgcggaca aggctcataa tcggtacgac caaaagcgct aagctgacca 2571541 tgcggatgac ataaacgaca tgatcaattg tcaggccgtt attatccttg cctcccagcg 2571601 atatttccgc aaacatcgga gccgatagat acagaatgaa aaaggctatc attcctgtga 2571661 ctagcataac cgacatgccc gccttgagca ttttcctgct tgtctcataa tccccttttg 2571721 aattatattt ggaaacaaat ttagaaacag cggccggaaa gcccatcgta gcaatattca 2571781 aaaataaagt gtattggttg tatccgtatt gaaataatgc accgcctgtc gccccgacca 2571841 taatgctgaa gggaattaaa tagaccatcc ccagaatccg cgatatatat gtaccgagcg 2571901 ttaatacaaa cgtgcctctt aacagtttgc ttgacatgtt tcttcatcac cattttctac 2571961 gaagattcaa cttttctatt ttaccacaac tgggcattta gacggtaata aatacaaaag 2572021 caatcctgtg aacattcatg tccgcggcaa aagacgttta aggagcggct ttctttcgct 2572081 ataatagtac tgcggacggg tgtccgcaca cgaaatgaaa agaaagttga tgataaagat 2572141 gaaacaatat gacgtaatcg taatcggcgg aggcccttca ggcttgatgg ctgcgattgc 2572201 agcaggagaa cagggcgctg gcgtgttgct gatagataaa ggaaataaat taggacggaa 2572261 actcgcgatt tccgggggcg gccgctgcaa tgtgacgaac cgccttcctg tggaagaaat 2572321 tatcaagcac atccccggca acgggcgttt tttatacagc gcgttttctg aatttaataa 2572381 tgaggacatt atcaagtttt ttgaaaacct cggcattcaa ttgaaggaag aggatcacgg 2572441 ccggatgttt cctgtgaccg acaaagccca aagtgtcgtt gacgcgctgt taaacaggct 2572501 aaagcagctc cgcgtaacaa tcagaacgaa cgagaaaatt aaatctgttt tatatgaaga 2572561 tggacaggca gcagggattg tgacgaataa tggcgaaatg atccatagcc aggcagtcat 2572621 tattgctgtc ggcggtaaaa gcgtgcctca taccggaagc acgggagacg gctatgaatg 2572681 ggctgaagcc gcgggccata ccataacaga gctgtttccg acagaggttc ccgtcacttc 2572741 tggcgaaccg ttcattaagc aaaaaacact tcagggctta tcactaagag atgtagccgt 2572801 cagtgtgtta aataaaaaag gcaaaccgat tatcacacat aaaatggaca tgctgtttac 2572861 ccatttcggc ctctcaggac ctgccattct cagatgcagc caatttgtcg taaaagagct 2572921 gaaaaaacag cctcaagtgc cgatcagaat cgacttgtat ccggatatca atgaagaaac 2572981 gcttttccaa aagatgtata aagaactgaa ggaagcaccg aaaaaaacca ttaaaaacgt 2573041 gctgaagcct tggatgcagg agcgctatct cctattcctg ctcgaaaaaa acggcatctc 2573101 tccgaacgta tcgttttctg agctgccgaa ggatcctttc agacaatttg taagggactg 2573161 caagcagttt actgtcctcg caaatggcac actgtcgctt gataaggcat ttgtcacggg 2573221 aggcggggta tctgtaaaag aaattgaccc gaaaaagatg gcttctaaaa aaatggaggg 2573281 gctttatttt tgcggtgaaa ttctggatat ccacggctac acaggcggat acaatattac 2573341 ctccgccctt gtcacaggca ggcttgcagg gctaaatgcc gggcaatacg cccgttctta 2573401 atcattactc tttaaatctc ttgccgccaa actcacattt gaacattccc cgcattcatg 2573461 ttagggtgag acttgttttg tttcacctga ttgcggggta attttaagag aggaatgagc 2573521 tgccatcgta cgaccatact aagcctgcga gcaagatata ggcgtacaca aaaaattaga 2573581 gggtgagaaa tgttgaaaca tatatctagt gtattttgga ttgtgattgc aatcacagct 2573641 gcagctgtat tatggggtgt tatttctcct gacagcctgc aaaatgtgtc tcaatcggca 2573701 caagcattta ttaccgattc atttggttgg tattatcttt tagttgtctc tttgtttgtc 2573761 gggttttgtc tctttttgat tttcagcccg atcggaaaaa tcaaactcgg aaagcctgat 2573821 gaaaaaccgg aattcgggtt attatcatgg tttgccatgc tgttcagcgc aggcatggga 2573881 atcggcttag tattctacgg tgcggctgaa ccgatcagcc attacgcaat tagctctcca 2573941 tcaggtgaaa cagaaacccc ccaagccttc agagatgcac tccgctatac gtttttccac 2574001 tggggtttgc acgcttgggc catttatgcc attgtggcat tatgcattgc ctatttccaa 2574061 ttccgcaaag gcgcacccgg gttaatcagc agcacactgt caccgattct cggggataaa 2574121 gtaaacggac cgatcggaaa ggccattgac tgtattgcag ttttcgccac tgttgtcggg 2574181 gtgtcaacaa gtcttggtct tggcgcaacc caaattaacg gcggtttgaa ttacctgttc 2574241 ggcattccga atgcgtttat cgtccaattg gttttaatca ttattgtgac agtgctcttt 2574301 ttactttctg cgtggagcgg actcggaaaa ggaattaagt atttaagcaa cacaaacatg 2574361 gtattggccg gattgttaat gttgtttatg ctcgttgtcg ggcctacagt gctgataatg 2574421 aactcattta cagattctat cggacaatac attcaaaata tcgttcaaat gagcttcaga 2574481 ctgacaccga acgatcctga aaaacgcgaa tggattaaca gctggacgat tttctattgg 2574541 gcatggtgga tttcctggtc tccatttgtc ggcattttca tcgcccgtgt atccagaggc 2574601 cggacgatcc gcgaattttt aatcggcgtc ttggtgacac cttgtatttt gacatttcta 2574661 tggttctcca ttttcggcgt atcagccatg gatctccagc aaaaaggcgc gttcaatgta 2574721 gcaaagctgt ccactgaaac gatgctgttc ggaacacttg atcactatcc gctgacaatg 2574781 gtgacatcga tccttgcatt gattctgatc gcagtattct ttatcacgtc agctgattca 2574841 gctacattcg tgctgggcat gcagacgtcg tacggttctt taaatccggc gaattctgtg 2574901 aaactcagct ggggtatcat tcagtccgcc atggcggctg tgctcctata ttccggaggg 2574961 cttgccgctt tgcagaacac agcgattctg gcagcgctgc cgttttctat cgttatcctg 2575021 ctgatgattg cctctctcta tcaatcgctc tcaaaagaaa gaagagagat caaaaaagcg 2575081 gagaaactcg ataaaccaag aagtccaaga gtgaaaaaag catattaaca aaaaagatct 2575141 ttccgcgcct gcggaaagat ctttttattt gcgatataaa ataagggcgg aaaaacagta 2575201 aagctgctcg ccgtctgggt cgcacgccgc cgaaaccgta tatttgatat ctatcagctg 2575261 ctcctccgat atccctttta aaaatgaatt gatttccgtt tgtaagtctt tttcatgctc 2575321 ttcatcaaat accgctacct tcagcatttt atccgctctc ctttctctat caatctattc 2575381 cgtttggaac agcgttatga tagagaaatg atgattatct cgtttccgga taaaaagctt 2575441 tccgtatatg ggatttcctc tgtggctcgc cgccgtgctg ctccactttc agcagcacgg 2575501 cataaacaat gcgcatatgg cagtagctga taaggctgac gctgaaaaaa gggacaatgc 2575561 ccggcaggta cgcaagcaag aaaaagagag caacagtcag cgcaagcata gtaagcgtat 2575621 attgcaaata cgccacactg agcaagagcg aaaatttcac atacagacgt tttttccagt 2575681 caaaatggac aagcagcgga aacacataaa aaagcatgga tacgaacaaa aagccaaata 2575741 tcataatggc gaagcgcagg atgtgcagaa ggaaatgact tggataaatt aaggccaaat 2575801 caatataaat gatcactccg atgagcgcca gtacagcgcc gagcagattt gaacgaaaaa 2575861 attcaccctt gtattcctgc caaaacgttt tgagcaccgg aacgttgtcc tgcccctgga 2575921 tccacttccg catgacagcg aataaagccg cggtcgcggg catgatgcca aacacgccga 2575981 gaccgagcaa cgtaaaaaac agccacagca agtttgtata cgcaaatctc ataatccatt 2576041 cgcaaaaacg cagcatccgt cccagtgagc catcatgttc catggcgccc cctccttttt 2576101 tgcattatac attctgcatc tgaaaaagct ctttcatgcc gatcggcttc ttttcggcaa 2576161 ccgagcgcca cattccctca ccaaccgcga tggagtaggc tccagcttca gccccggcta 2576221 aaatatcata gcggcgcagc gggtctttcc ctaaaaaaag atcctcaagc aaaagcggat 2576281 cacctccgcc atgcccccct tcatttttga ccacttgtat cgtctgcttt gattcaaaaa 2576341 gcggatagta ttcgattgtc tgctcaggaa aagcaaacgg aattctggaa ggttcgtgaa 2576401 attcatttga ttcaatacgt ccttttgtgc cgttgatcgt cagccggtag ccttcatacg 2576461 gggccgaaaa aataatcgag tagcttaaca gtgcgccgcc atcatatttg actgccgcca 2576521 cgtacgtatc ctcgatgtca atttcctcgt caaaaataca cgcgtcaggc ctgtatgcag 2576581 tatataagct ggactggtct cctgcttcaa gatgatcatc ctttatagaa gctttagagg 2576641 aacggggatg ccaccttgaa tagtagtggc atttttcttt aacacggcac gtcccgcaaa 2576701 aacgcccgtc ttcttccggc aaggggttcc actcactgtc cggcccatag taattcaagg 2576761 cgccataagc aaatacctct tccggatttt gcccgagcca ccaattgacg agatcgaagt 2576821 gatgtgttga tttatggaca gaaagaccgc cggaaaactg tctcgacctg ttccagcgtt 2576881 taaaatagct ggcgccatga tacgtatcaa tataccaatt taaatcaaca gaagtgaccc 2576941 tgcctatttt tccgtccaga atcatttctt ttattttccg atgaaacggg ctgtagcgat 2577001 agttaaacgc gacggtgact tttccttcgc ttttggcctc cgcttcaagc acccgattcg 2577061 catcctgcac tgttgtcacc attggttttt cagtaatcac atctgtattc cactgaaggc 2577121 tttttacaat atatgcgaca tgcgtatcgt ccctgcctgc cacaatgacg atatcaggct 2577181 ttgagacgcg catcatctcg tcaaaagcat cttcgctaaa ctcaggcacg tgggccagct 2577241 cgggaaattt cttcttgcaa acggcaaaac gtttcggatc ggcatccagc aatcccgtaa 2577301 tctcataatg agttgaaaac cgctccatca gtggtttgat aaacatactg aatgctctgc 2577361 tgctcaatcc gcaaaagacg atgttcttca atatcctcac ctctatcggg cttcagttag 2577421 ttgagaaatc agctgcagcg cttcctctgt tttttcagca tacacaggga taaacgccgc 2577481 catatcgcga ttcaattgaa aagaatagcc gttcagctgt tttttccctt tttcgatctg 2577541 aacggcatag atcgtttttt ctcctgtttt tttattaaca gttgtataag gagatgtttt 2577601 ttcaggaggc aatccgttta acggctgaaa attttccgga tcatcgtaag cttgaaacat 2577661 gtcttcaggc acgatgaaaa catctccctc atgggcggta atttcagtca gcagtttttc 2577721 ctgaaaagct ggaaagatat cgaccttccc ggcattctgc tcggcggcct tttttatttt 2577781 ttcctgtacg ccagcctgca tatcagaaaa gagaatgaca tgcattccgt ccggcctgct 2577841 tgagcatgat gccaaaaaga gcactgagac gatcacacac aaagccgtac gtatcctttt 2577901 tgtcatttcc ccgctgacct aaaaagaggc tccagctctg tcatagctaa aataaacgcg 2577961 ccggctccgt gcagatcgtt tgtgcttctt tcgcggctga cataatagtc atagaaaccg 2578021 gctgacgttc cgacacatat gtctttgacg agaaacgctc cgtcttctga tgtttcggtt 2578081 ttatgctgaa tcaagccttg atacgctttt agcagtgttg tttcgtaagc tctgtctaga 2578141 tagcctttat tgattccttt tgcgattgcg tacatgtaca gacaggatcc tgagctttcc 2578201 agccagttat cagacctgtc tcccttatca acgatctggt accataaccc cgtctctttg 2578261 tcttgatagc gacagatgct tttaatcatg tcctgcagcg tgtttttcca cacatgacgg 2578321 ttcggatgct tcttcggcag ctcttcaatc atgtcagcaa gagacatgac gtaccagccg 2578381 atggaacgtg cccaaaattc cggtgaacag cctgtctctt cattggccca aggcattttt 2578441 ttcgcttcat cccaggcgtg ataaaaaagt ccggtttttg catccttcgt atgctttctc 2578501 atcaatgact cctgaagcac aacctgatca aacagctccg tctcctgctt cagattggca 2578561 tatttcagtg caaacggccc ccccatgtat aagccgtcaa gccacatttg gtaaggataa 2578621 ccgtctttgt gccaaaaacc gccctcagac gtccggttca gtgttccata taagctgcgc 2578681 agcctttttg ccgctttgac ataccgttca tccttcgtct gctcgtataa tggaaaaaga 2578741 atgagacctg cttgaatggc gtccagttca tctcttctaa ataatagatt gccattatca 2578801 tcgattaaga gatctgcata agccttcgca tactcaaaat accgcttttc cccggttgct 2578861 tcccacagcc gcaatacacc gcataagaaa acaccctgat ggtagtgcca gcggtttgca 2578921 ggtggcagct cctcgactgt gtacgtgttc ataatggtgt ttgccaatgc ctccgcgtac 2578981 gtaagaggcg attttacagc gattgattga tccattgatc ccatcccttt cctaataaat 2579041 tccttcctcg ccaaatttct tcgccaaacg attcgctagc atgaccaaaa tcagcccgac 2579101 cgccgcttta aatacgccga ctgctgtact gtagctgaat tggccctgtt tcagccctgc 2579161 agtataaaca tacgtatcaa aaatttccgc cacttccctg ttagtcgcat ttaacagcaa 2579221 atacacatgc tcgaagccaa gctccagcgt gtctccgatt ttcaaaatca gcaaaacgac 2579281 gataacgctt ttaatggcgg gcagcgtaat atgccacatt tgccgcagcc gtcccgctcc 2579341 gtccattttc gccgcttcat acagctgggg gtcaaccgct gtaatggccg ccagataaat 2579401 gatcgtcgac cagcccgctt ccctccagat aacctgcaga atatacaggg gccggaacca 2579461 ttcttcgttc agcagaaaat tgattttttc accgccaaaa aacacaatca gttcattaat 2579521 caagcctccg tctaccgtta aaagcacaaa cgaaagcgat acaacaatga cccaagacat 2579581 aaaatgcggg atataaatca gcgtctgaac aaatttttta aagagagcaa tccgcacttc 2579641 gttcaataga agcgccagca gtatcggcac cgggaaaaat atggccaggt tcaaagcaaa 2579701 taacacgagc gtgtttttta acaagagaaa aaatgtaggc tcagtaaaca gcctgataaa 2579761 atgcttcagc cccacccact cactgcccaa aatgccgagg aacggctgat aatcctgaaa 2579821 cgcaatcaca attccccaca tcgggacata cttaaaaagc aaaaaataaa tacaccccgg 2579881 caaaatcatc aagtacaaat atttttgttg aatcagcttg attagtaagc gctttctttt 2579941 ttctttttta aaaatgactg catcaacagc cggcgcttgc gcttctgctg ttttcatttt 2580001 ttcctagcct cctttcacgg attcttgcat tcactgtagc gcagcaggca aaagtccgtc 2580061 tacaatcata tgatcacatc ctgttttatc cctttataat caagggttca gccggtccac 2580121 ctgaaaaaaa gacaccgata ttagaaaatg attattgaca atatctatca atctttggat 2580181 taattgtatt aaggtgaagt ggatgttatg aaatgggggg ttttatgaaa agaagccaat 2580241 acaagtttta ctacaaactg atcacgtttt tctgcctgct cagcaccatt ccggttattt 2580301 tggtcggatt attttcgtac gagcactctc agaaaacggc tatttccaac gtttcggagg 2580361 aaaaattcga cacactccag cagacccagc aaagcatcga gcatatattg aaaaccgtcg 2580421 atcactcttt aacccactat gtgagttcgc cgcctctcct tcgcacattg tccgagcctt 2580481 tgcactcaga ccaatttcaa atctataacc aagtgaacca agagctcaat tatctgcaaa 2580541 gctttgatac cgatctgtcc aacatgacgt tagtcagtta tacgaaaaaa tggtacatga 2580601 acaattccgg tttgtaccgt ttgaatacag acactcttca tgaagcagcc tcagcgtaca 2580661 cgaaacaaaa agcgagccgc tcctattgga cgcttgagga aaacaatcat ttgatttcaa 2580721 ccaaagaagg cacagcagaa aactgccgct acaatatcaa tttaattaag cagcttcctt 2580781 tgaacagcac aaatacaaag ggattggccg ccgcaagcat cccgagctgt tcgcttgtca 2580841 aaaatatgcc cggctattca aacgccaaca acctgtttat catcgatgaa aaaggcctca 2580901 tcatccttca taacaatatg tctgacgttg gtgaatctct tcataacgac ggctttgtcc 2580961 aaaaagtgct ggcgcaaacg gccaatagcg gacagtttga aacagtgatt gaccggattc 2581021 attataaagt cacctatcaa aaatctgact ataatgcatg gacttatttt tctctcgttt 2581081 ccctgcctga gttaaaaaaa gaagccaaat caatcggctg gatcactttt gcagtatgcc 2581141 tcattttgtt aacgctttca ttgctgttct cttggcttgg ctcccgccat ttttacaagc 2581201 cgatcagggt gctttacgaa tcattcgcaa gacatggagc catacaagag aaacaacagc 2581261 ctcctcaaaa tgaatttgag ttaattgaac agagctttaa gcagctgaag gacagaaatg 2581321 acgaccttga agaaacgatg aagcagcagg ccactcatct gcagcaatat tttatggtca 2581381 ggcttatgct tggaaaactg acggatgagg aggttgataa ccgttttgaa agcctcggct 2581441 taaagcaaaa ttggcggcac cttgccctgc ttgtgctcca aattgacaca ctgaatcata 2581501 cgccttatga gaaaaaagat atggatctgc ttttgtttgc cgtcaacagc ctgattgagc 2581561 gcaacatccc gacggacaaa catcttgccc ccgccgtagt tgacaaacag caggcgacga 2581621 ttttgatcaa tcaaagcggg acaaaggaag aattcatggc tgagctgaat gagactgcaa 2581681 ggatgattca ggaaaaagcg gaagctgagc tgcagctgtc tgtcagcatc ggcatcagcc 2581741 agccgtttga tgtgctgaca aaagcgaaaa cagcctatgc ggaaggctca gaagcgttga 2581801 aatatcggct gaaagcggaa aacaagtcga tcatctttta cgaagacctt gaccagaaaa 2581861 aaaccttcaa aacccatttt ccaaagcagc ttcagcatga gctgttcgat gctgtcaaag 2581921 caggagacaa ggagaaagcg gataaatgcc tgcacgcgat tttacaagcc attttcaccc 2581981 agaacaccaa cccgtatcaa tttcaaatcg ccatcgcccg ttttttgaac catgtgattg 2582041 agctgatgca tgtgcttggg atcgaattgt ttgagcttga agaaaacaaa atgctgtatg 2582101 accaaatttt tgagctgaaa acgttcgagg ataccgaaaa ctggctaaag aatgagttta 2582161 ttgatccgat gacagacaaa gtgaacgccc gcgcggatgc ccagtacaaa aatatttccg 2582221 acaacatcat tcatatcatc catcatgagt ttgaatccga attgacactg gacgaaatcg 2582281 cacgcaggct gcattacaac ccaaattatt taagcagtat tttcaaaaaa gaaatgggaa 2582341 tttcattcag cgagtatgtc tcaagctacc gacaccatat ggcgaaaagc tggcttgccg 2582401 aaaccgacat ggcggtcaag gacattgccg aaaagctgaa atataaaaac tcccaaaact 2582461 tcatcagatc atttaagaag ctggaaggga ttacaccggg aaactaccgc cagcaaaaaa 2582521 gaagcatgta aaaaacccaa aaccgcttgc gcgttttggg tttttccaat gttattttgc 2582581 ttgtttaaac gcttcttcgt attcctgaat aatttgtttt cctccgcttg actcccattt 2582641 ttccacttct ttatcgaact ggctttctgt gatgtctcca atcatatatt tgtaggtcgc 2582701 gtcatcaatg attttcttca gttcgtcacc ccgttccgac tccgatgcgg aatacaggct 2582761 ttcagccggg tttgagacga taatcttttc attgtcctcg gtcagctcct cgtacgccgt 2582821 ccgaagcgga tctccagtgt tttttaagta ggctttatca atggcaatta aagcggacag 2582881 cggctgaata tcagtctgcc agtcttttac ctggctttct ttgcgtgtaa acgttttgtc 2582941 ctcacctttg ttgtaatgaa cgccgtcaat gccataagtc atcaggctat agacatcttc 2583001 ttcggcaatt cggtcaaaaa acgccaagat ccgtttaagc tcagcttccg ttttcacact 2583061 cgttttcggg aaagcaaaca cgccgttatg gcctcctgat gcccataccc gctctttccc 2583121 atctgggcct tttatgcggt tgatgatctc gagcttcatc gatttatcag aggcatggtc 2583181 gcgcagattg accgcatcta ccatattgcc aatataaatt ccggcttttc cttgagaaaa 2583241 cagctcttgc tgctgggttt tgcttgtgac gggaaaatcc ttattcatat acccgttatc 2583301 acgcagcttt ttcatatagt tcatcgtgtc tttgtattcc tgtgtcatga aatcaggcgt 2583361 gaatttgccg cccgattcct tccaatctgt cggcatgcct tcatacgagc caatcgtttt 2583421 aaacgcgccg taaatcaagt cattacggtc tgccagcccg aatgtatcat ctttcccatc 2583481 cttgtccggg tcgtcctccg taaatgcttt ggccacttca taaagctcat ccaacgtttt 2583541 cggggttttc aaatttaaat tgtccagcca gtccttccga atgacgatcc cctgtctgga 2583601 aagcgggcgc tctctgtata tcccgtagag cttgccgtca attgtcacat ttttattaat 2583661 gagtttgttc attttgttta agttgggata atccttgata taatcgccga tttcccaaaa 2583721 cattcctgac cgaaaggcat tcatgactga cgaattttta atatcctgga tggtcacgat 2583781 ttgcggaaga ttgccggctg caagcgctgc attcagcctg tcttctttca ccgcgtctgg 2583841 aacccaggtg atgtcgagtt ctgtatttgt cagcttttca atttctttaa tcgccctgtc 2583901 tttcggcggc tgctggtgat acaaaatcgc catccaagac agctttacct ttgaatctgg 2583961 gccagctttg ccttcagccg aagactgatc agttccttta cagcccgcca gcactccgcc 2584021 gagtgccagt acaagcacaa tcaaaagcac cctccatttg tttcccatcg tacccctccg 2584081 tttcatattt ctttatcctt tgacagatcc cagcaaagct ccttttgcaa aatgcttttg 2584141 tataaacgga tagacaagca gaacagggat ggtcgccacc actatgaccg ccattttaat 2584201 ggtttgctca ggcggcgggc tgcccgaccc catttcagac atatccccct gcataccgct 2584261 tgatacaatg acgatttggc gcagaagcac ctgaattggc cattttgctg aatcatttaa 2584321 gtacaagatc gctgtcatat acgtgttcca atacgtgacc gcataaaata gtgaaatcgt 2584381 tgcgatcgca ggaagagaca gcggcagcac aattttaaag aatatgccca gatcattgca 2584441 cccgtcaatt ttcgcggact cttccaggct tgacgggata ttttgaaaga agtttttcag 2584501 aatgatcagg ttaaaggcat taatggctgt cggcaaaata agcgcccagt aagaatcgag 2584561 caatccaagc gatttgacca caaggaaagt cggaatcatg ccgccgctaa acagcatcgt 2584621 aaatacgacg agaaacatga gcggctgccg gccgattaaa tcacggcggg ataacccgta 2584681 agccatcagt gacgaaagaa acatgctgac cgcagtgcct atcactgtca caaacacaga 2584741 aacaagcaaa ctcttataaa taatatctgt tgaaaaaatg tagcgataag catctagcga 2584801 aaaagtggtc ggtattaaaa taaatttttt cgacacgact tcttctactg tggcaaagga 2584861 tgctgcgata acatgaatga acggaagtac gcatattaaa gcgaacatca gcaagaaacc 2584921 ataaatcaac atatcaaaca gacggttttt cagtgaatgt gcgatagctc ccacctccct 2584981 ttgtaagcgt tatcatattt ttggaaaccg agctcagcat gtgacgatat cgtgtctaaa 2585041 atgtagcaaa tctgtgattg ccatgtctat aatcatttga acagtgtccc cggccgggcg 2585101 ggggctgccg cgaattgaga ccgataacaa aagaaaaaga gcataatctt agaaaatgat 2585161 tatgctccgt tctcctcctc gttcagaagt tcagccgtat tgatttgtgg cgaaaaccca 2585221 agttcattca cggcagattc aatggaccat ggccggcccg gattatcaga gacggcgtaa 2585281 taagtgccat accggatgtt ggtctcaatg gcggctttga aaatcgacag cagatcgggg 2585341 tgagaaagca gtgtcttttt cgtccgttct ttttcatgca gcgtatccat ttcatctgtc 2585401 acgactgttc cgattcgaag gttgattact gatagcttat tttccaaata aaacaaatgg 2585461 ccgatctgtt cagaggtcag ctttaataca ccgtacaagt tttttgacag cggataatcg 2585521 cttgttgtga tttcccgtcc taagagcgag cgcccgtctt tttcatatac atctgtgaca 2585581 tgattgctgc tggcgaacac gagcttttga atgccgagct ccgctgccgc acggcacaga 2585641 taatagcttg ccctatagaa aacatccgtc attttttcaa actcagcgat gtccataata 2585701 tcgtatttga ttttcacagc gagtaaattc aagatggcat cggtatcttt tggaatcttc 2585761 ttcaacagct cctcataatt tgccgcgtca gcctgaatgg aagaggcttt gccatcgaaa 2585821 tgatctttat caagcacagt cacttcatag tctgaaataa gcccttcagc aagcagtctc 2585881 ccaatcacac catttccgcc ggcgatcagc acttttttca cgatgttcac tccccttttt 2585941 tatagattgc ccattttcgg cggggctgac acttttttgg cactcacatt cttaggctta 2586001 ttcaaaagtc accggcagct cctcaagcgc ccgaaatcca aaaagcggcc gataccgcca 2586061 ttcaaaatcc gcaagattaa ggctgggcat tcgctgcaga agagtgttaa tcgcaatttg 2586121 cgcttctaat cgtgccagcg aggaccctaa gcaaacatga tggccatgcc cgaatgaaag 2586181 atgcggatta ggacttctcg taatatcgaa gacatcgggg ttcgtgaata tgctagggtc 2586241 tcgattagcc gctcctaaca aaagatagac ttgttctcct tgacggatcg tcaccccgca 2586301 gatgtcaata tcctctgacg caactctggc tgtcatttgc gtggggcttt catagcgtaa 2586361 acattcctcg actgcggtac caataagatc tggattttct ctcagtttca aaagctgttc 2586421 tggatgctgc agcagacaaa ggactgaatt gctgatgaga ttgaccgttg tctcatgtcc 2586481 ggcgatcgcc agcaatatgc acgtagatgc cgcctcctct tccgtcagct tatccttttc 2586541 tctccccttc aagagcatgc tgatcatatc ctgttgaggg tggcgttttc tcttttgaat 2586601 cagctctttg aaatatgcca tagcctgcac agccataata ttgccctctg ttaatgcctt 2586661 tcttgagcgg gtaaaatcaa tcgtttgaat gagactcgca gcccactcct ttaattgctc 2586721 cctatcttcc tccggtacac ctataatgtt agctatgaca aaacttgcta aaggaaaagc 2586781 aaagtccgaa atgacctcca tctttttttt accttgcact tgatcaagca aatgatggac 2586841 agtttcaatg atatacggct gataactctc tgtcgttctc ggcgtaaacg ctccgctggc 2586901 aagcgtccgc aatcgtctat gatcaggctg gttctgaaac agcatcattt gattttgcac 2586961 atgtgaaagg tcctgatatt tggttgagct ctcaggcagc ggggtgcgga ctttgaatct 2587021 cgcatctttc aaaatagcag ccgtttcttc atatcctgtg acataccagc ccgggtattt 2587081 taagaaactc cctttataga taggatgaac agctcgcaat gtgtcgtaaa aagaatatgg 2587141 gtttttcaaa aactcagaag atgcagttga cgatgcaatt gtcacgtgat tttctccttt 2587201 ctgttcaaaa ataaaaacaa tcgacatcat accgattgct tttattgatt ctttcagctt 2587261 ttcgcactta aactagcctt catttcttcg actgattcaa cttcaaagcc taaatcactc 2587321 agcattttat gatcctccgt ctcctcttgc ccggcagttg ttaagtagtc tccgacaaaa 2587381 atggagtttg cggcgtaaag ccctaatggc tgcaatgtgc ggagattgac ctctcttcct 2587441 ccggaaatgc gaatttcttt tgatggattg ataaaacgga acagcgccag cacttttaaa 2587501 caatacagcg ggtttaattc gttgacgcct tctaacggcg tgccatcaat tgcatgcaaa 2587561 aaattcacag gaatggaatc cgcgtcaaga gccttcaagc ttttggcgat gtcaatgaca 2587621 tcctgtttcg tctccttcat cccgataatg gcgcctgaac acggagacag ccccgattct 2587681 tttgcgattt caaccgtatt gactctgtca tcgtatgtat gtgaggttgt gatgtttgaa 2587741 tggtttctct gtgacgtatt caaattatga ttatagcggt ctactcctgc atctttgagc 2587801 cgcttcgcct gctctggctt caacagtcca agacatgcac aaatcttcag tccatacgtc 2587861 tctttaattt cctgaaccgc atctacgacc tgatccactt ctctgttaga cggacctctg 2587921 ccgcttgcca cgatacaata tgtgccgata ttcagatcgt gcgcccgctt cgcgccttca 2587981 agcagcgttt ccttattcac catccggtaa gactcaatcg gcgctttcga aatcgcagac 2588041 tgtgaacaat agccgcagtt ttccgggcag agcccggatt tcgcattcat aatcatattg 2588101 agctttactt tttttccgta aaagtgtttt ctgatgtgaa aagccccgtg cattaatagc 2588161 aaaatatctt catcaggaca atgtaatatt gaaagcgcct cttcgtcagt cacttctgct 2588221 ccagccagca cccggtctgc gagttccatc cattgattca ttctcatacc cccacttgat 2588281 tcatcagtaa tgatagattg atatggtctt ttaccatatg tagaaccgtt tctttcgtca 2588341 cgttggcaag ctttggcgta acccctaaaa tcggcacacc gcataagcgc tcaatcatct 2588401 caggattggt tttttcatct tcatcaggag agtcactgat tccattgatg ataattccgg 2588461 cgattggaag ccccatgctt tctgcatatt tgacagttaa aaaggtatga ttaatggttc 2588521 caaggcgagg acgcgccaca ataatcatgg gaagctgcaa cgcttttatg acatgactga 2588581 ccaaatagtc ctctcccaat ggcacagaaa taccgcctgc accttctacg atgaagcatt 2588641 catgtttttc tctaatccgc ccccaatggc ttaaaacctc ttccatggtg acagtctttc 2588701 cctcaagttt ccctgcaacg tatggtgcaa gcggcgcctt gaaggcaaaa ggcgtaatgt 2588761 cttcatgaga aagactggtc tgcgacatat ctttcagcaa acttgtatca ctatctggat 2588821 gatggcgcga tatcccgctt aaaaatggtt tatacacccc gacatgtcta ttattgtctt 2588881 tcaataaggc agcaagaccg ctggatataa ccgttttccc tacttctgta tcagttcccg 2588941 tcacaaaaaa acccctcaaa tgatgtgcag ctcctttccg attgaatgaa atgtttgcag 2589001 caaatgatca atatcaccca tactgtggtc agacgtgatt gtaattcgaa tccggctttc 2589061 acccggcgca acggttggcg gccgaatggc aggagcataa attcccttgc cctgcagttt 2589121 ttcagcaaat aggaccgttt tatgggcatc gccaatgact acaggaataa tcggtgtgtg 2589181 atctcctttc accacataac ccatattctt cagactggtt ctgatcatgc tgatataaga 2589241 aaataaaagc tgtcgttttt ccctgctggc ttcaatgatg ttgaaagcct cgtgagcagc 2589301 cgcacagctg gctggcggaa tagcggtttg aaagataaat gttctggcat ggttcagcaa 2589361 aaagtcgatg aagaccgctg atcctgccgc aaaacctcct tccgcgccaa cagctttgct 2589421 taaggtgccg ataacaatgt cgggacaaac accaaagtat tcactcgttc cttgtcccga 2589481 atcgcccaaa actcctgttg cgtgggcatc atcaacgacc acgaaggcat gatagcgttt 2589541 cgcaagtgag atgatctgat caagaggggc gattgtgcca tccatgctga atactccgtc 2589601 tgttacgata aaacggcgct gataacgctg tgtttcattc agcttgtttt caagatcatt 2589661 catatcaata tgccgataaa caactgtatc agccttagaa agtcggcagc cgtcgatcat 2589721 acttgcatga ttgagctggt cacttaaaat gacatcttcc ttttctggca aggatgaaag 2589781 gacaccgaca ttggccaagt aaccgctcga aaacagcagg gccgcttctg tcagtttaaa 2589841 gctggcaatc ttcttttcta gcttttcatg ccagaccgaa ttgcctgtcg ttaaacgtga 2589901 accgctgctt cctgtcccaa attgctgcaa tgctgtttgg gctgcatcga tcaaacgtct 2589961 atcgcttgcg agccctaaat aattgtttga ggaccagacc gtttgatttt cgccatcaat 2590021 attcctctct ggaaccggcg ctccatccat tgaccgcagg ttacgatgta cgccggcttc 2590081 tttcattctg tctaaccgct cgtttaacca ggaatcaatc ttcaaggctc gtaacctcgt 2590141 ggatcgcttg tttcataatg gcaaccattt ccgagagctc ttcagctgtg ctggcaagag 2590201 gaggaagaaa tgcaatcacg tccccaagcg gtcttgtcag cattcctaac tctctcattt 2590261 ttaaggaaac tttgtatcca atccgccgat cagccgggta aggttcttta gtttcctttg 2590321 atcgtacaag ctctgcaccg cacataaagc caagctgccg aatatcccca acatgaggaa 2590381 gagcgtgcag atcttgaaga agaaaatgga gctttttact tttttccgct acttgttcca 2590441 caatgttttc agattcaaat aatgccagat tttcaagcgc aaccgcacag ccaagctgat 2590501 tgcctgtata ggaatggcca tggaaaaagg tttttaggtt ttcataatca tcatagaatg 2590561 ccttatagat gtcttcagtg gcaaacgtaa cggcaattgg caaatagcct cctgtaatgc 2590621 ctttaccggc agccatcaga tcaggctgga cattctcgtg ctcgcacgca aacatttttc 2590681 ctgtacggcc aaagcctgta gcgacttcat caacgatcat taagacatcg tatgttgtac 2590741 atagctcgcg cacgcctgcc aaatatcctt ccggcatcac gatcataccg gacgcgcctt 2590801 gtaccattga ttcaatggaa agcgcggcaa tttcctcatg atgttcctca agcagctgtg 2590861 caagctctcg gaggcactga tcacggcact catcaggatc accgctttca gaacgataca 2590921 cataaggaat cggggccttg taactctcga acatcaacgg gccgtatacg tggtgaaaaa 2590981 gctcaattga accgacactg acggcgccaa tcgtatcacc gtgatacccg tttttcattg 2591041 cgatgaattt ttgtttctcg ggcttcccga tgttcttcca atactgaaac gccattttta 2591101 gggctatttc catcgcctct gcgccgctgt ctgaataaaa gacccgcgtg agcttttttg 2591161 ggctgatgtc gattaatgtt tcggcaagct gggttgctgg aacattggtc atgcccaata 2591221 acgtggagtg cgcaattttt ccgagctgtt tttttatggc gtcatctagt tcttttttgc 2591281 ggtgtccgtg gacattaagc caaaccgatg aaaaaccgtc atagtattcc ttgccgttta 2591341 tgtctttgac tttgattcca gtcccgcttt cgatgattaa ggggttttca tcataatctt 2591401 tcatttgggt aaatggcagc cagaggtgct ttttactttt ttctatcaaa tcatgagtca 2591461 tgatcttcct cccactctat taaaataggc tgcttctcca ggtcatgtat gtacgtgttt 2591521 acatcattgg atccatcaat aaaaaagact cggcagccct cttcagtccc gtattctttc 2591581 attgctgtaa tacgctgata gcccattttc ttacccgcaa catagcctgt tatgtaatcc 2591641 ggatcgtccg accagcataa ttctgcaacg actgccgggt gccggcttac ctttgaagcg 2591701 agcgcaaggg cctcttttat tcttgaatga gctggcacgt gactgtgaag cgcccatttt 2591761 tcaaaattag cgtccggcca atccattctg gagacccgca cccctttttc ttttgtttga 2591821 tccattcgct tgcctgtatg aatatcaaac aacaccgcac ccctgacatc tgaccattca 2591881 gggatttgtt catatgcttt ttcaatcacg tctcgtgaaa cgccttcttt ttccaataac 2591941 aatcgggcaa gcttttgtcc ttcttccggg cagctcactt cattcgtatg cacaggcaat 2592001 ggctgaatgg tttttatcga ttcatgtacc tcttcaaatt gaatttgcat aaaatcaggt 2592061 tttcctcttg aatgggataa ccctttttct aataaagcat tgactgtatg cttcatctca 2592121 tggaaaggaa taagccgttc tccgccggat atatgctttc cgccgtcttc atgagatcca 2592181 ttcattgaag ccctcattct gacactataa aaagtttctt cttgcatcat ttctcgccct 2592241 ttcactgata actgaagaac gtgtagcgct tctcacctaa attgttaacc aattatattc 2592301 aaaggttaac aattagaata tattattctc tcctgtttct gtcaatagaa gaaaggatcg 2592361 atttatggca gttggttaaa aggaaacaaa aagaccgttt tcacacaaaa cggtcttttt 2592421 cgatttcttt ttacagtcac agccactttt gcaaaaaccg gacagcttca tgccttataa 2592481 ctgctgtttc gaaatgtccc gaagcagaac ggaccactcg gtagcaatca gcagctccct 2592541 gtccagcata gacagctgtc aattcttttt cgattttgtc cacgccctca gccggcgtta 2592601 accgatcgtg tacaccaaca agactaaggt gcgggcgcgg cgcgatcagg ctttggatct 2592661 ccgatgcgga aaaatgcttt gcaagcgatg ggacgtaata ataaaagccg tgcctgtcaa 2592721 gattctgtgt tttgatcagc acgtgatgat ccacctggct gcacaaatcc acacacacct 2592781 taatccggtc atcgagcgcc gctgtccacc acgccatcaa acctcccata gacatgccga 2592841 tggttccgat cctgtcaggc tgaacatcag agcgtgactg catatagtct aacgcactta 2592901 aactgtcata aatcatcatc ccccacatca cttttccggt gagaagcatt tctttaaata 2592961 tctcgctttc cgcttttccc cgccgatctc caaaccccca atgatcaatc gcaagaacgc 2593021 cgtatccgag tgaagtaagc tcatcagaaa aagaaggcgt tttcaaataa tccgctccct 2593081 caatcagctc actttttccc ctatcatact ggcctccatg cgaatgctga aacaatacgg 2593141 ctgggcacgg tccttctgtt ttcttcggct tcacaaaata agcgggcgcc ttttcatgtc 2593201 catttaaatc gagcaggagc gtttcaacga tattttcttc tctttcttca atacgtaatg 2593261 tctcaacact gattggcctc cgatcaggca aatcaccaag caatcgaaac agttgctttc 2593321 ttctttcggc tctcatccca tcacccttcc ttattcgctt acttcacatt tacgagacag 2593381 atctgggttc ccctttattt ttccaacata aatcacatca tttactaaat atttagtaaa 2593441 tattatggaa tatttcgaaa acaattattg taaccgctta cttttatatg ataatatcaa 2593501 tttatcaaaa acagatgagt taatatttta ctaaatagat gagagggata cccatggttc 2593561 gtattaaaga tatcgccttg aaagctaaag tttccagcgc aactgtgtcc agaattttaa 2593621 atgaagatga gtcgctttct gttgcgggcg aaacgagaca aagagtcatc aacatcgctg 2593681 aagagcttgg ttatcaaacc gttgccaaac gccgaaaatc ccgcgggcaa aaacagcggg 2593741 ctcagccgct gatcggtgtg ctgagctgtc tgtcccctga tcaggaaagg caggaccctt 2593801 atttttcttc cattcggaaa gggattgaaa aggaatgctt tgaacaggaa attttcatta 2593861 caaattcgat tcatctcggc tcctttcagg aacatatctt tcgggaattg gatggtgtca 2593921 ttgtcatcgg ccgtgttcat gatgaagcgg ttaagcatat cagcgggagg ctggagcatg 2593981 ccgtatttat caatcattca ccagatccgc aagcatacga ttcgattggc atcgattttg 2594041 aatcggcttc acgccaggcg attgatcacc ttttcgactt aggctacaaa cggttaggct 2594101 acattggcgg acaagaaaaa gagcatacgc tgaaggacgg ccaaagcatt cgcagaacga 2594161 ttgaagataa acgcctgacc gcttttttgg agtcagccgc cccccagcct gagcatgtgc 2594221 tgatcggaga atacagcatg cgtgagggct atcgcctgat gaagaaagca atcgatcaag 2594281 gccatctgcc ggaagcattc tttattgcca gcgattctat ggcgatcggc gcattaaaag 2594341 cgctgcagga agccggactg caagtgccgc gggataccgc aatcgtcagc tttaacggca 2594401 ttgaggaagc tgaatttgcc agcacgcctt taacgacggt gaaggtatac acagaggaaa 2594461 tgggccggac aggcgtaaaa ctgctgcttg accgtctcaa tggccgaacg cttcctcaac 2594521 atgtcaccct gcctacaaca ttaatcgtaa gacaaagctg cggatgtaca gcaaaggagg 2594581 tgacataagc aaagattcat cacgatgata aggaggaaaa gatgaaacac acttttgttt 2594641 tatttctctc tcttattctg cttgttctgc ccgggtgttc agcagagaaa agctcagcag 2594701 ataccgcaaa aaagacgtta accatttatt ctacaatgtc aaccgacagt gaaagagata 2594761 cgttcagaaa actagcggca gcattcgaaa aggaacacag tgacattcat gtcagccttc 2594821 atttcccagg caatgactat gaaaatatga tgcgtgtcag aatggcggcc aatgatttgc 2594881 cagatctatt cgatacacat ggctggggga aaatcaggta cggagaatat acagcggatc 2594941 tccgggatat gaaatggact caagatcttg atcccaattt aaacagcatc ctcaaaaata 2595001 aaagcggaaa ggtgtatgcc tatccaatca atcaggcaaa agacggtctg gcgtataatc 2595061 gcaatatttt agaccgttac ggcattgctc cgccggaaac catggatgac tttatcaaag 2595121 cactgagaac gattaaagaa aagagcaagg gaagcattgt tcccttctgg tttgccggat 2595181 atgacaaaag ctcattcgcc caatattacg accaattcgc tacacctctt ctcatcacag 2595241 accctgccca taatgaaaaa aaacagctca tcaacggcac ttttcaatgg agtaaattca 2595301 cttatttatc agaaatcctc aaacaaatgc agaaagaaaa attgatcaat atcgacgccg 2595361 tcacggcaaa aaaatcacag ctcattgaat taatggccca aaacaaaatc gcctttacaa 2595421 tgcaaggcgg cacactcggc caagacgttg cccagatcaa cccgaacgtc aaggtcggca 2595481 ttatcccgac acctgccatc catcccggtg atgacccgat atggatcggc ggtgaacgct 2595541 acacccttgc agcatggaaa gattcgcctc aattaaaaga ggcaaaagat tttatcgcat 2595601 ttatggcccg cccggccaat gccaaacaaa tggctgaagc cacatcgctt ccttcagggc 2595661 tgaccaatgt gaaagctgat attttctacg caaacgatta tgagtattat caagatgtca 2595721 aagtcgagcc ttacttcgac cggttatact tgccaaacgg aatgtgggat gtcctgggca 2595781 cggttgggca ggagctcgcg gctgacattt tggcgcctca agacatttcg cagaagctgg 2595841 gaagagaata taaacgactc cgggagcaat ccgaaacaca gggagctgaa aacaatgagt 2595901 gagatcgcaa gggacgttca tgtgaaacag gttaagccaa aaaagcagtc ctcactttgg 2595961 tggatgtaca ttcctgcttt gctctccgtt ctggtcttta tgatttaccc gtttgtgaaa 2596021 ggcacattga ttacctttac aaactggaac ggattttcac aagtctacca atgggttgga 2596081 ttcgcgcaat atgaaaggct gttttctgat cctgatactt ggcatatctt aaaaaacacg 2596141 ctgcattacg ggcttggcag cacctttttt caaaatgtgg tcgggcttct gtacgctctc 2596201 ctcttaaatc aaagcattaa aacgaaagcg gtaacaagaa caattgtgta tttgccggtg 2596261 atgatcagcc cgctcattat gggctacatt tggtactttt tcttctccta tgacggaggc 2596321 gcgctcaacg atttgctcgg ggtcttcggc atcagcccta ttaatgcgct cgccagtccc 2596381 tcgctcaatc catggatcat tgtcatgatt aacacctatc aatatgtcgg gatcgctatg 2596441 gttgtctact tagccggtct gcaaagcatt ccgaaagact actatgaagc ggcgcaaatg 2596501 gatggcgcga aacaaggcca gcagtttttt accatcacgc tgccgctgtt aatgccctcc 2596561 attaccatta atatagtcat caacattatc ggaggcttaa agctgtttga cgtcatcatt 2596621 gcactcaccg caggcggccc cggaaatgcg tcacaatcca tgtccacgtt tatgtatgat 2596681 ttgtatttca aacggcagga tgccggctat gccgcaacgc aaggcatatt tatggcattt 2596741 gtcattttga tcatcagctt ttgcgcgctt gcgtacttta aaagaaagga gacggaaatg 2596801 tcatgagagc cgcccgtaca aaaagcatgc ggatcattac gcttcttgca gccattgtgg 2596861 cctgtgcgca ttttattcct ttttatatcc tgctgaccac ttcattgaaa gcaaaaggag 2596921 actacagttc gaaatggata tttccagccg acatctcctt tcataatttt tcagaggcgt 2596981 gggagcgcgc ttcgctagga aactctttta taaacaccat gatcatcaca ggtttttctg 2597041 ccttgttatt aattatattc ggctcacttg ccgcctaccc gcttgcccgg cgggaaacga 2597101 aactgaataa agccgttttt gccttgctga tttccattat gatcatccct ccgttaacgt 2597161 ccatggttcc tttgtaccga atggtcgtgg acgccggaat ggtcaataca cacgcaatcg 2597221 ccattttcat caatacagcg gcttacatgc cgttaaccgt attcttatat tcaggcttta 2597281 tccgatcgac cattccaaaa gagcttgtag aagccgcaag aattgacggt gcaggcatgc 2597341 tgaaaatctt ttttacgatt gtgtttcctc tgctgaagcc gatcactgcg accatctgta 2597401 tcatttcttg tgtctttatt tggaacgact atcaatttgc cattttcttt ttacaagatc 2597461 aaaaggttca gacattaaca gtagccatgg caggtttttt cggagaaaac gcaaacaacc 2597521 ttcatttagt tgccgcagcg gcacttatgg caatgctgcc gatggttgtt ctgtttttgg 2597581 cgctgcaaaa atactttatt gccggcctgt cttccggagc ggtaaagggt taacattaaa 2597641 gggggaagca atatgaaaaa gattacattt atcggtgcag ggagcacgat tttcgccaaa 2597701 aatgttttgg gagactgcct gttaacagag gcactgaatg gatttgagtt cgctctttac 2597761 gacattgatc ccaaacgcct gcaggaatcc cagctcatgc tcgaaaatct aagagaccgt 2597821 tataacccaa gtgtggccat caacagctat gatgacagaa aactcgcctt gcaaaacgca 2597881 ggctatgtca tcaatgcgat tcaggttgga ggatacaaac cgagcacagt catcgatttc 2597941 gagattccta aacggtatgg gctgcgccag acgatcgccg atacagtagg catcggcggg 2598001 atattcagat ctctcagaac aatcccggtc ttatttgata tcgcaaaaga tatggaggaa 2598061 atgtgccctg acgcatggtt cttaaactat acaaatccaa tggccactct tacaggcgcc 2598121 atgctccgct ataccaatat caaaacaatc gggctctgcc acagtgttca agtgtgcacg 2598181 aaggatttat ttaaagctct cggaatggag catgacggaa ttgaggaacg cattgcgggc 2598241 attaatcata tggcttggct tttggaagtc aaaaaagacg gcacagattt atatccagaa 2598301 atcaaaagga gagcgaaaga aaaacaaaaa acaaagcatc atgatatggt gcggtttgaa 2598361 ttaatggata agttcggcta ttatgtcacg gaatcgtccg aacataacgc agagtatcac 2598421 ccgtacttta ttaaacggaa ttaccctgaa ctgatcagcg agctgcaaat cccgctcgac 2598481 gaatatccga gaaggtgcgt caagcagatt gaaaattggg agaaaatgcg ggatgatatc 2598541 gtcaataata aaaaccttac gcacgaacgc tcaaaggaat atggttcaag aattatagaa 2598601 gcaatggaaa caaacgaacc attcaccttc ggaggaaacg tcttgaatac agggctgatc 2598661 accaaccttc cttcaaaagc ggttgtggaa gtgacatgcg tcgccgacag aaaaaaaatt 2598721 acaccgtgct tcgccggaga actgcctgag cagcttgcag ccttaaaccg gacgaatatt 2598781 aatacacagc tgatgacaat cgaagcggct gtcacacgaa aaaaagaagc ggtttaccaa 2598841 gctgcaatgc ttgatccgca tacaagcgcg gagctttcca tgaaggacat catctccatg 2598901 tgcgacgatt tatttgcagc acacggcgat tggcttccgg aatacaaata aaaactaggg 2598961 gaccgctctc ccctagtttt ttggttttgt ttcgccttcc caggccatca tgccgccttc 2599021 aacattgact gttttaaagc cttgctcatc caggtacttg cagacgttca tgctgcgcat 2599081 tcctgagcgg cagataaata cgtactcttt gtctttatca agggtttcca ttttttcagg 2599141 aatatccccc atgcgaatat gaacggcttg cgggatcatg ccttccgcta cctcttcatc 2599201 ttctctgaca tcaattaaat ataattcttc gtccgcctca attttttctt tcaaagcggc 2599261 tgtgctgatt tcttttattt ccaaagaaaa cactcctatt cacagtgatc atgttcagta 2599321 tatcaaagtc agccgaacga ttgctattct gagactgatg aaaaaaaatc cccttttggc 2599381 aaaggggatt ttttctaggc ttagtttgcc acaatattga caagcttccc aggcaccgcg 2599441 atgattttcc gaatcgtttt gccttcaagc tgctctttga ccttttcatc tgcttgagca 2599501 agctgttcca gctgttcttt cgttgcatcg gcaggaacct gtaatttcgc ttttactttt 2599561 ccgttcagct gaacaacgat ttcaacttca tcatccacaa gttttgtttc atcatataca 2599621 ggccaagctt cgtaggcaat tgtgccggaa tggccaagct tctcccatag ctcttccgct 2599681 aagtgtggcg cgacaggaga aagaagcttc acgaagcctt ccatatattc tttcggcagt 2599741 tctgttgctt tataagcttc attaataaag accatcagct gggaaatacc cgtgttgaaa 2599801 cgaaggcctt cataatggtc tgtgactttc atgaccgttt catgatagac gcgctccaat 2599861 gtttcacccg cgccttcaac gatttttcca ttaagctcac cgctgtcttc aataaatagg 2599921 cgccatacac ggtcaaggaa acggcgcgca ccgtctaatc ctgattcaga ccaggcgatt 2599981 gaagcatcaa gaggtcccat gaacatttcg tacaatctca gcgtatcagc accgtgagag 2600041 gccacgattt cgtcaggatt gacaacgttc cctttagatt tactcatttt ttcgttgttt 2600101 tcgccgagaa tcattccttg gttgtacagc ttttggaacg gttctttcgt cggcactacg 2600161 ccgatatcat aaaggaactt atgccagaag cgggcataca gaaggtgaag cacggcatgt 2600221 tctgcaccgc cgatatacat atcgaccgga agccattttt ccaatttttc tggtgatgcc 2600281 agctgatccg gattgtgcgg atcaatatag cgcaagaaat accagcagct tcccgcccat 2600341 tgcggcattg tattcgtttc tcttcttcct tttttccctg tctcagggtc tgtgacttcc 2600401 acccactctt taatgttcgc aagcggtgat tcgcccgttc cgctcggttt gatttcatcc 2600461 gtttttggca aaatcagcgg cagctcctct tccgggacag ctgttgacgt tccgtcttcc 2600521 caatgaatga ccggaatcgg ctcgccccaa taacgctggc ggctgaagag ccagtcacga 2600581 agacggtacg tcactttctt ctcaccgttt ttcgtttctt ccagccaagc gatcactttt 2600641 tcaatcgctt cctgtttgtg aaggccgttc aggaaatcag agttcacgtg ctcgccgtcg 2600701 ccagtatagg ctgcttcctc aacgttcccg ccttttacga cttccttcac cggaaggccg 2600761 aatgttttgg cgaattcaaa atcacgctca tcgtgtcctg gaactgccat gacagcacct 2600821 gttccgtatg atgcaagaac ataatccgca atccaaatcg gcagtttttc tccgtttaca 2600881 ggattgatcg catacgctcc tgtaaatacg cctgtctttg ttttcgcaag atctgtgcgt 2600941 tctaggtcac tctttgattg aatttctttg atataagctt caacagcttc tttttgctct 2601001 gccgttgtga tgttttccac caatgcgtgt tccggggcaa ggacagtgta tgtagcgcca 2601061 aacagcgtat ctggtcttgt tgtaaacact gtaaaggaat catcatgtcc atctatagca 2601121 aaatgaacgt gagcgccttc cgaacggccg atccagttgc gctgcatatc tttaatgctt 2601181 tccggccaat caagctcttc caagtcctca aggagcctgt ccgcataagc ggtgattttc 2601241 agcatccact gcttcattgg gcgtctctct accggatggc cgccgcgttc gctcttgccg 2601301 tcaatgactt cttcgttggc aagaacagta ccgagcgcag ggcaccagtt tacaggcact 2601361 tcgtcaacgt aagcaaggcc tttttcgtat agctttaaga aaatccattg cgtccattta 2601421 tagtattcag ggtcagtcgt attgatttcg cgatcccagt catatgagaa gccaagcgct 2601481 tgaatttggc ggcggaagtt atcaatattc tgcttcgtaa acacagcggg gtcgttccct 2601541 gtgtcaagcg cgtactgttc agctggcagg ccgaatgcgt cccagcccat tggatgaagg 2601601 acatcatagc cctgcatgcg cttcatgcgg gacagaatat ccgtagctgt gtatccttca 2601661 ggatggccga cgtgcaaccc agctccagac ggataaggaa acatgtccag cgcgtaaaat 2601721 ttttgttttt cattattatc aagagtggca aatgttttgt tttcaagcca atatgtctgc 2601781 catttctttt ctatctcttt gtgctgaaaa ctcaaagtaa aaacctcctt ctgattgaat 2601841 acggcgtgta tggttcaagt attgacggga aggagaggat tatattcaga atattcccaa 2601901 actaaaaaaa actccctcat cccaaaaagg gacgagagac tttcgttttc ccgcggtacc 2601961 accctcgtta gcgcggcata cgccgcactc acttgatact tttaacgcag ttatgcgtca 2602021 gcggcttttc accgctgcaa ctctgaggtg agttcggaaa caaacttgat tgactttcac 2602081 cagccgtcaa ctctctgcaa caatatctgt ttcttactgc tcctcttcat tgttcttatc 2602141 gcaaccgtaa tctaactgta ttttatagaa ttctgttcat aagtgcaagc aggtttgtat 2602201 acaatgggaa tgtaccctga acgggcggag attgaggaca attattcggg tggagttttg 2602261 gtttgacgtt tggactcggc cggttcgccg ccgctgttca gttctctcac aaagtcaaaa 2602321 cttctgagaa cagcttcacc gccgtagcct gagataatgg ataagatgac aagttgaatt 2602381 cctgaatcgg ggtcagcgga taatacaagt aaaatggaag ccgtcatgcc gataaaccaa 2602441 tcttccaaaa atccaaggta gataaaccgc ttcgtcattc tgggcttctc cagcctgcct 2602501 ctctttttca catgaccgag aatccccatg attcctccaa ttacacaagc aatgagtacc 2602561 tgatgcagca tcttcatcat caccttccta aagcccttat ttcgtaaagc gacttcaggc 2602621 catccagccc ccttaaacga ttccgatgat tttcgatatc tacataccgg caaatctgta 2602681 aaaagcttgt ttcttccatt atatgtgaac acatgatcgg taagcttgat gcattggatt 2602741 catttttcac ccagtgacat tgacctagtc acctatttag catgtagaaa acctttccgt 2602801 tcatatgttc aaattctgtt cttattttta gtgtatacga ggacaagccc taatgacaaa 2602861 caacaaactg cacttgcttg aatcagaaca tgtgttgtgc tacggttact gtagaattca 2602921 tttttaaaaa ggggaatatc aggctttcgc atagcaagct gacggcctaa gggggattta 2602981 tatggctagt tttcaatcat ttgggatacc aggacagctg gaagtcatca aaaaagcact 2603041 tgatcacgtg cgagtcggtg tggtaattac agatcccgca cttgaagata atcctattgt 2603101 ctacgtaaat caaggctttg ttcaaatgac cggctacgag accgaggaaa ttttaggaaa 2603161 gaactgtcgc ttcttacagg ggaaacacac agatcctgca gaagtggaca acatcagaac 2603221 cgctttacaa aataaagaac cggtcaccgt tcagatccaa aactacaaaa aagacggaac 2603281 gatgttctgg aatgaattaa atattgatcc aatggaaata gaggataaaa cgtattttgt 2603341 cggaattcag aatgatatca ccaagcaaaa agaatatgaa aagcttctcg aggattccct 2603401 cacggaaatt actgcacttt caactcctat tgtcccgatt cgcaatggca tttcggctct 2603461 tccgctagtc ggaaacctga cagaggagcg atttaattcc atcgtttgca cattgacgaa 2603521 tatcttatca acatccaaag atgattattt gatcattgat ttatccggat tggcccaagt 2603581 gaacgaacaa acggccgacc aaattttcaa gctgagccat ttgctgaaat tgaccggaac 2603641 tgagttaatc attactggca ttaagcctga attggctatg aaaatgaata aactggatgc 2603701 caatttttcg tcgctgaaaa catattcaaa tgtaaaggat gccgttaaag tgcttccgat 2603761 tatgtaaaaa gatcccgctc acccagctgg atctttcaga ttgttgacaa aatcctaaaa 2603821 tggttttcat tttaggattt tgtcatcttt tcagcgtgat tgaaaaccct tgaagtctag 2603881 gaaggacgag cataggagcg gagcgaatgt tctaattcgt gagcaccgaa gcgcaggcct 2603941 gacaacgaat gcgagggttt gtcgacacgc tgaaagatcc cgctcattcg gcgggatctt 2604001 ttattatgaa gagattgatg cctgcttatt tgtttcttta gctgatttta tccgtttgtc 2604061 atatagaagc gttgtggcaa tactgatcag cagcaatacc aacagagata aaacaagagc 2604121 cctaatgccg taatgatcga caagcactcc tccgaacagg ggaccaatca ttctgccgcc 2604181 tgtcgccgca ctgttgacaa agccttgata aaagccttct ttccctttag gggcaagctg 2604241 attggcaata gtcggcacag caggccaaac aagcatttct ccgatagtca ggatcaccat 2604301 cgcagcgaga aacatcggaa attgctttgc agtcagcagc atgctgaaag acacaataaa 2604361 aatgataaag ccgatgacca tttgcgcttt tagcgactcg gcccattttt tcaccacaaa 2604421 actgacgagc ggctggccga gcacaatgag aattccgtta accgtccaca gcacgctgta 2604481 taaggaaaga gatattccaa tgctttgtgt gtacgaagca attgtggttg accactgaga 2604541 ataagccagc catccgagta catagcctcc gcttaaaatg atcagtgcgg caaattttgc 2604601 tttgctgttc acagcatcat aatcaagcac ggatgtttgg gatgcatcgc ccgtttgaat 2604661 atttcgaaat ccgaaatata caataaagaa aaagatcaga tacaatacgg catttgccaa 2604721 aaatacatat gaaaacgaga aagatgccac gacaccgcca agcgctgaac caacggccac 2604781 gcccgcgttt tgcgcgacat atatcgcatt aaatgccttc cttccccctt caggccatac 2604841 cgatcccgcc attgcgtagc ttgccggaaa aacaacaccg gagccaaagc ccacaatcgt 2604901 cagcagcaca atataggctg gccaatcatg aaaaaagaca agacccatca ggcttgctaa 2604961 cgtaatggct atcccaagca taatcgattt aaaaccgccg attttatcaa acaaaaaacc 2605021 tccgcataaa ttgccagcca cactggcgcc ggaattcagc atcaggacaa gtccggctac 2605081 tgttaacgac tttcctaaat gattatggat ataaatcgta ttcagcggcc ataaaaaaga 2605141 agcacccgtc acattgataa acattccaat gactaaaatt ttaagagcac gcggcatact 2605201 catccccctt tcttacctaa aaaagctcat gaaaaaaacg aaacctaaaa cggctccgta 2605261 cgaatccagt tatcatagca cattcattct atctgtctct ctcacatttt tcaactgatg 2605321 agcgtgaaaa aatctaacaa atattgtttg aaaaatgtaa aataaataga aaaaggggtc 2605381 atattatgga aatggtatta gcattcttag gttttctggc atgtctcatt gcactgggct 2605441 atggattata tcaccttgtc agatatgtac tgaaaaagga aaaacgtttc tcaaagagac 2605501 ttttttggcc gcttttcatt ggaggccttg tgctgctctt taccggggca gcattggcag 2605561 aacctgacac tgccgcagca aatgccgaga aaaaatattc agcgctaaac gccgaatata 2605621 aaaacctcac aaaagagcac gaagaacttg agaaagaata taaatctgtc agctctgaag 2605681 caaagaaatt aaaagacaac aaagaagatc aagacaagct tgagaagctt aaaaacgaaa 2605741 atagcgatct aaaaaagact cagaaatcat taaaagctga gattaaagag cttcaagaaa 2605801 atcaaaagca gctcaaagaa gatgcaaaaa cggcaaaggc tgaaaatgaa acacttcgac 2605861 aagataaaac aaagcttgaa aatcaattaa aagagacgga aagccaaacc gccagctctc 2605921 atgaagacac tggaagttct tcaaacaata cgagtaaaag tgatgaaacc aaaacagctg 2605981 acaaagcaga aggctgtaat atcaaaggaa gcagaaacgg catctaccac acgccaggca 2606041 gtacatacta cgaccggaca accgatccgg ctgaaatgtt ttgctcagtt gaagaagctg 2606101 aagccgccgg ttatcgggcg ccaaaacgat aaacaaaaag ctccagaatg tctggagctt 2606161 tttctgtttc acaacgacga tttaatgacc ttcttataat aaagaactga cagaaaacca 2606221 aaaatggagt agagcgcagt atataacacc atcaccataa tcataggcgc ccatacctct 2606281 gatccgaata agaaccagcc ggattggacg gcaaagtaac tgtggaagag gccgacaacg 2606341 agcggaatgc cgaagttgta catttgtttg atgcgtatcc cctttatcag gtcgccctgc 2606401 gtaaagccga gttttcttaa aattgtatag ctcggttttt catcttcact ttcacccatt 2606461 tgtttaaaat aaaggataca acctgatgta atcaggaacg ttaaccctaa gaagccgacg 2606521 atgaacatca ccataccaaa cagtgatttt tgcgcagcgc ttgtatctag tcttgataaa 2606581 tgctcgtttt tcttgttcac ctgttgaaaa agctcatttg ctttttccat ttgatcgtca 2606641 tgtttcacat tgacgccgat aaatgtagat tgcgccagct gaatgcgggg gtctttatcc 2606701 ttgtccagct gtttaaacag gctgtcatcc acaatgacag cgggcatgcc cccgcttgta 2606761 aacgtgtagg acacaagaaa ctcttctctt aatcctttat attttaatgg ctgcgtctcg 2606821 tgcttgcttt ttactttaat aacaccagag tccttgaaaa ccattatttt ttgcagcaag 2606881 tcggtgtatc ctgagaaaac ggcttctcca gccgccacat cgactccttt tacatctttg 2606941 tcgctaacaa cagcaagctg catattgccg ggatcgccct gcatctcttt cggagttcca 2607001 tccataatat ttgcaatgtc aacatttgct tgcaggacag gtgttgcctt ttttacaaac 2607061 gagatgttgc tttccctcaa tttgttttca aataacttgg catctttctc attcatgaat 2607121 gaaaaatcag ccgctacatt ttgttcagcg gtcttttccg acgagtaata cgagatgtaa 2607181 gcaagagata acagcccgat ggcgagcgct gaaacggttg taataatcgt cagcagcagc 2607241 gcattcgatt tcattctgaa catgatcgaa gacagtgaca gaacctcaga aatatttaag 2607301 tagccgccct tgctttttcg aatgatattc gagataaacg taactgatcc tttataaaac 2607361 aaaaacgtcc cgataatgac gctccccaga atgaagctca tcgcaacaaa cagttcatta 2607421 atggtcttaa attttccgcc aaacagctca gaagacacat agtatcctgt caaaatcaac 2607481 acgatgccta aagcgccgat cagcatttgg aaaaatgata ttttcttcac tttgtcttca 2607541 gtggaggacg ttactttaaa caaagataaa atactctgtt ttttgataaa cgtataattc 2607601 atgatcatga tcaaaaggta aatgccgcag aacacaatga ccgtttggac caaggcctgc 2607661 tcagaaaaat gcagtttcgc atccgctttg acatcgacaa ttttgaacag aatcatcaag 2607721 acaagcttcg atatcgaaaa cccggccgct accccgatcg ctaatgaacc gaaatacagc 2607781 atgacatttt ctgcacttaa gatgcgaaaa attttatgct tcgtcattcc aattaattga 2607841 aacagcccga tttctttact ccgtctctta ataaaaatcg tattggcata taaaatgaag 2607901 atcgccacta cagccacaag caaaatcgaa gcggttttaa tagccgcggc tcccttgatt 2607961 gaagccttca cttcgttaat tgctggatca tactgcagcg tgacaaaggc gaaataaagc 2608021 gccacgctaa agatgagcgc aaacacatac aaatagtaat tccggagatt ctttttcaaa 2608081 tttcgcagga tgagctgatt aatgttcatg ctgcaccccg cctaacacgc cttgcgtttt 2608141 cataatatcc tggaaaaacg tttgcctgtc ctggccccct ttattcagct gtgtatacat 2608201 ttgcccgtcc ttaataaaaa tgactctgcc gcagtagctg gcagcgacgg gatcatgggt 2608261 aaccataata atcgtcgcgt tgcgtttttg attgagctgg ctcagcttat ttaatagatc 2608321 ggaggccgat ttcgaatcga gcgcgccggt cggttcatca gcgaaaataa tgctcgggtc 2608381 atgaataaac gctcttccag cggatgttct ctgcttctgg ccgccggaaa tttcattcgg 2608441 gtatttatcc cgcaattcat atattcccag ttccttggca acttcctcaa acttgcgatt 2608501 ggcttccttt tttgatagtt tcgtgatcga taaaggcaga aggatattct ctttcactgt 2608561 caatgtgtct aacaaattgt aatcctgaaa gataaagcct aaatgctgtt ttctaaattc 2608621 agccagctgc ttttccttca tagccgtcat gtcatttcca ttaatatgaa tggttccgtg 2608681 actgacctga tcgattgagg acagaacgtt gagcaaagtg gtttttcccg acccggaagc 2608741 acccataata ctgacgaatt cgcccttttc aatgtgaata tcgatgccct tcagcacttc 2608801 ctgtttattc agcttgtttc cataactttt tcgaatttta ttcgcttcta aaatcaccat 2608861 ttacgcagtc tcctttatat tggataatct cattataaaa aggaatgccg ggcttttcct 2608921 tcgatacggc gaacaaaaaa gaaaagcatg tgacattttc gtcacacgct tatgacatgt 2608981 tcaaattgat tccgtattgg aaaggttaat gtaaaaactg ttcccgcacc aaactccgac 2609041 tcaacatcaa tatggatcaa taacggcgcc gctgcttttt ttgccaagta cagccccatg 2609101 ccagttgacg cttgatcatg gtgatccgtt gtggatgtaa accctttatc aaaaatacgc 2609161 ggtacatctt ttggatcaat gcccctgcca caatctttca cttggagctg cgtctgttcc 2609221 cctttttgaa agcttttgat ctcgatttca gaggcttcgc tgtatttcac cgcgtttgtc 2609281 agcagctgcc tgatgataaa cgccagccat tttgcatcgc tcagcacttc tttggcctcg 2609341 agctgtatgt caaaaccgat ccctttttgg atacaccacg attgtaaatc tttgatttct 2609401 ttaaagatca aaggctgaag ctgaatgaat tctactgaca ggtcgttttc aataaatgaa 2609461 atgcgttttt gatgaagctg ctgatcaaga agcaggtgaa tacgcagcca ttcatatgac 2609521 agctgggatt tcagtgcttt ttcttccatt ctatcaatga ttaaatgcat cgctgttaat 2609581 ggagttttga cctcatggat ccatgccatc agctcatctt tttcattttc caatgctaag 2609641 cgatgccgtg ctgcggtctg cttcaagtgt tctgtttgcc cggcaatgct tctttcaacc 2609701 attgcttcaa acggcgtttc cggttcattt atggctgtca catcgagatt gttctcccat 2609761 gttttcaagc ttttataaaa cgctgtttct ttccgatagc ggaaccaaag gaatatgata 2609821 aaaaacaaga tgcacaaata caccatataa agtacattcc caaatgatat ggaaggatcg 2609881 acaaaagcaa tgaacagcat caaagcctgc tgaaacaaaa acgcggcaat ccagctccgc 2609941 ctttcgataa ggaatgcttt aatcatagaa cttgtcctct tccttcgcga tgtagccctg 2610001 gcccaccttt gtctcgatat atgcaccaag ctgcagggcg tccagttttt ttcgcaggcg 2610061 attgacattg acggtcagcg tattatcact aacaaaacgc tcatcgttcc acaagcttct 2610121 gatcagctct tcccggctga cgatcttgtt tttttgctct attaattgtt ttagaatgaa 2610181 catttcattt ttggtcagtt caacagatcc tttgtcattg ctgacgaggt tctgctccgc 2610241 gtctacagca gcgccgcacc acgttttaat cgtactcggc tccgtattat aatggtgcac 2610301 acgccggaac atcgcttgga ttttcgcgat cagcacatca aaatgaaatg gcttttgaat 2610361 aaagtcatct gccccgagct gcatggacat caccatatca gcaggatgat cccgggagga 2610421 taaaaagaga atcggaacat ttgaccggga gcggatcaga cggcaccaat gaaagccgtc 2610481 aaatttaggc agctgcacat caataatgac acaatcagga ttaaccgccg caaattcctg 2610541 cagcacctga ctgaaatcct gaatgccgta tacatcatag gaccatcccg ttaaacgatc 2610601 cttgatttca tgaaacagcg attcatcatc ttcaatcagc aaaagtttaa acaatcgact 2610661 caccgcactt tttccttttt tatcaagtgt atagcaaaac gccagcatgc gctatagaaa 2610721 aagccggctg tctcagccgg ctcgttcgca ttataattct cttctcaacg ctgtcagcac 2610781 gttggttttg gtagcttttc tcgccgggtt cattccggaa atgactgcga cccctccgca 2610841 aatcacaacg gcaatgatca caaggctcgc cgggatgtag gagaatgtgt aattcaaatc 2610901 gcccgcatcg ccaccgcttg tggccgcaag aatcatcgga acggccaggt tgacaaggta 2610961 gctcacgccg taagaaatga taatcccaat cacacagcct aaaattccga tatacgcgct 2611021 ttccatcaag aacattcggc gaatgattga cgggctcgcc ccaatcgctt tcataatgcc 2611081 gatctcttgc gttctctctg tcaccgccat cgtcatcgtg ttaaaaatgc cgatcgctga 2611141 aatgataact gcgatacatc cgacaaagat cagtccgatt ttgaagacca tgaagaaggt 2611201 attggctccc tcaagttcag tagtcactga tgtgacatag tacccgtcat ctgttagatc 2611261 atttgtcagc tgttccacat tctcaaactt atcagcaaaa acaccaatgt tcgtttcaac 2611321 atttccgcct ttgaaatcta agaattccga aaaatctttt ttgaattgat cactgataaa 2611381 aatatttgag tcctccatcc agtcttgaga tggttttttt gtaataccga caattttaaa 2611441 gtcatatgtt tttgtttttg taacatcccc tgttttagaa tctgtcttcg atacacttag 2611501 ttcaattgtt ttatttagaa tatctttcgt atagcccttt ggttctttta tatcttctgg 2611561 atttcctttt gcttcctcga tttttttgtt atattcttcc gattcttttt tcgttaataa 2611621 tctctttgcg aagtcgtatc ctactacgat ttcattttcc gactttgcga ctcttccctt 2611681 ttccaattcc atattggcct ttaattcatc attcatatta gtaaaaatga gatttgagct 2611741 ttcatttgta cgattgccta aagtagcttt gtttggttca tacacttgcg ttctttctac 2611801 aactgacctt acgtgatcat acttctctaa atcagctttt ttaatcggct tgtctccttc 2611861 cttgcccatt acgctgactt tcgttacaat ctgctggctc attgtcatat ctgtaatcgt 2611921 cttttgaatc ccaaatccaa cggacgacaa cacaaccaaa aacgcacacg ccattgttgt 2611981 cgccagaatc gtcataaaga cgcgaagcct gtttttcttc atatttcttc tgataaaatg 2612041 aacctgatcc ttaaacctca acggtaattc ctccttttag cacaccatca tgaagctgaa 2612101 attttgaatg tccgatagaa gcgacttcat catcgtgagt aatgatcaca aatgtaatgc 2612161 cacgctcacg attcagctgc tggatcaatt ccagcacttc atgttccgtt tctgaatcaa 2612221 ggcttcccgt cggctcatcc gctaagataa tcgaaggatt taaaatcaat gctcgagcaa 2612281 tactgacacg ctgctgctgg ccgcctgaca gttcattcgg ataatgagcg gcgtggtttt 2612341 ccagaccgac gcgtttcagc atgtcctgca ccttttgctt ccgctcagat ggcttgattc 2612401 cttttaacgc cagcggcatt tccacattct catacgtcgt taaacccggg atgagctgaa 2612461 agctctgaaa aataaacccg aaatggtcaa gccgaaattg cgcccattcc ttttcattaa 2612521 accccgtaac atcagtgcca ttaatgacaa tccgcccttt tgtcggcgat atgtagccgg 2612581 aaattaaatt caaaagcgtt gatttccctg agccgcttcg tccgacaatg caggcgattt 2612641 cccctttcgc cacgctcaat gaaacatcct tcaatactgg aacttcattc tcacggccct 2612701 tttttccgat cgtgaaagaa tggtcgatat gctgaacatc aatcatatgt tctctctccc 2612761 ttacaaaagt ttcatttttt tataaatcgc aaaataacta atcaagaaac cgattaccgc 2612821 acctgtaccc atgccaatga gataaccggc aaagctctcg cttgcagtaa atccaaaata 2612881 gccgaagccc atgattccta tgataataac gatgatctgc accgggcggt taagcggctt 2612941 ccataagaag aaatatccgt ttctttcatt agacatttta acaaagctaa tatagccgat 2613001 gatgtaaaaa atgatagtca tgatagccgg aatgactaaa taatatggtg aattctcagc 2613061 ccatttcgag tctacataaa ttatcggaat gaaatactgc acccatttag gtactggacc 2613121 atggataaaa tctattgatc cgccaaaaag gatctcgagg ttgatcacag gcaggctgat 2613181 gagtaaaaac ggcgaaatgg ccacggtaaa tgagactaga agctgtgcga aactattgcc 2613241 tgtcaaagct cctccggcca taaccaaaga ataagccagc atgctaacaa taatcattcc 2613301 caagctgtaa ttgtgaaaat aaacggcctg atctggcttc aaaagcatga tcagcaaaac 2613361 agacaaaaca taacctatga gctgcggcac cacaatcacc attccgccgg taaggaactt 2613421 cgcatgaaat atctgccctc gtgtatatgg aaggcttaat gtaaaatcaa agaagctctt 2613481 gctacgttca atcccaagct ggctgaccgc caaaacgact ccccaaatcc aaaacaatga 2613541 gataaatgag ctatttaaat aatcaacgct gaatacgcag gggccgaccc aattttcttt 2613601 tccagtgaca cagccttgat agatgagata catatttaaa attgataatg gattacctaa 2613661 tataaaaacc aaaatggtga taactaaggc gactttattc tgccgccact ctttgtaaag 2613721 cagtccggaa tccggcaact cacttccctc caaacctaag gcatttctta cacttttgtt 2613781 ttcttataaa tagagaagta gctcacaaag aatccagcca ctgctccaat gatcataccc 2613841 aaaatataac caataatgga atgtccggta tagtatccaa ataaaccaaa tccaaggatg 2613901 ccgaaagcca taaccagaat ttgcaccggg cgatctaatc tgttccataa gaaaaagtgt 2613961 ccgttccgtt cacttggaag cttcttgaag cttataaagc caatcaagta aaatagcatg 2614021 ctcattacgg ctggaatcaa taaaagatat ttactgttaa tcagccattc atttacaacg 2614081 taactaatcg gtactaggtt cgataaattg cttgccagag agaaataact ctcaggggaa 2614141 gggaatattt cccatatatt cgcaccaaaa acaacttcta ggtttccaac cggcaatgca 2614201 ataattaaat acggcaatat agctgctgaa aacgccgtta acagttgggc aaaagcattt 2614261 ccagttaacg ctccggcggc catcaccagt gaaaaagcca taaaacttat cacgattact 2614321 ccaatgctgc tgtgctcaaa aaagtagacg tgttcagggt tatagacaag aatcagcagc 2614381 catgcaagta aaaagccaat caattgtgac agcacaatca caaaaccgcc taaccaaaat 2614441 tttgtctgaa aaatttggct tctgttatac gggaggctta atataaaatc catcgtgcct 2614501 ttcgaacgct ccattccgag gaagcagacc gccaaaatga cacccggcac ccagttgata 2614561 tctatcagat tgcttatgga ataattcaca ataaaatcac aatattgcgg gtcttggcga 2614621 tcaagacacc cttgataaga caaatacgta ttaacgatag aaagcggatt tgccaatact 2614681 aaaaacgcga tacttaacaa aatcaccact tgattctgct tccactctcg atagaggaga 2614741 cctcggtcta ccatctccgc ttccctccaa acttcgcaat gaacacttct tccaggttga 2614801 caggaagctc attccacact tttggcttca gctctctcaa aaagctcttt ttctcctcat 2614861 cgcttttcgg aatcagcact gtgtaaaaca cgccggcctg atcgagcatc ggaatgtttt 2614921 gctctctgat ggccaaattg acatctgtat cgaaggccat ttgaatttta atgtattctt 2614981 cttttaactc atcaagatcc atgacgttgg tcaggctgtt atcttcaaga aaaccaattc 2615041 ggttgcacat ccgctctatg tcttcaagcc ggtgggacgt aatcaggatg ctcgtatcac 2615101 gctctgccac ttcatcgacc atcagctgca gcacatcatg ccttgtcacc gcatcaatac 2615161 catccgtcgg ctcatcaagg aggatcagcg ccggtctcgc cgcaaacgac agaacgagcg 2615221 atagctgctt ttttaagcct gtcgacagct cacggtattt tttcgtttcc ggaatttcgt 2615281 atctgttcat cagctcattc gcgtacgtga catcaaattt cggatatatt cttctcaaaa 2615341 tatcgactaa ctgcttgtat gtatacttat cgtaaaacgg attttgaaca ggcatgtaga 2615401 tgatattttg tttgactttc gggtgctttt tgatttctac gccgtcaaat aaaatcgttc 2615461 cgctgtcagc gaaaatgatt tgctggatta agcgaagcat cgtcgttttg cccgatccat 2615521 tgcgtccaag caatccaaag atttctcctt tttcgattgt taatgaaaca tcttttaata 2615581 cttgattgcc gtcaatcgct tttgacagct gccgcagttc aatcattttt tttgcctccc 2615641 ttcacatcag cgctgatttc ctttatccat tcgtgcagtt tttccagctc aacccctgca 2615701 tagtgtgcat cgatgatgag ctgtttgagt tgctctttaa tcatcgtcat cttcccttca 2615761 accagtgtcg tttttgcatt ctccgatata taggtccctc tgccccgcag cgtttcaata 2615821 atcccctctc gctcaagttc tttatacgct ttgctgacag tgttcggatt cgcaataatg 2615881 atcgttgcca attctctgac agaaggaagc ttatcaccag gcttcatgat ccctttcaaa 2615941 caaagctctt tcatttgctg aataatttgt tcgtaaatgg gtgttgagct tcttggatcg 2616001 atttgaatca tttacttccc tactttctat acgatctgaa ccttttatag ataaaaatga 2616061 tcaattatac ttttttgcca ttcaaaaccg atcatcacaa gaacaagaaa aaaagaacaa 2616121 gcgatcacag atgccgcaat cagcattggc acgttacgtt tgtttcgttt tttatgtttc 2616181 ataactgcct cccttaatgt caatatataa atgattttat attagtgtct atagtgtatt 2616241 acttcaatta gtacacttaa tacaataaat actttgactc acaaagtcaa tccttttttt 2616301 acaaaaaaac ggaccctttt aaaagggtcc gttttcctac acatcaagag ggtgctgcag 2616361 gatcatatta ttttgcaaag attgaagctg aagtctcatt ctgtacagct gttctctctg 2616421 ctgatcattt gacgacagcc atagtttatt caaggcattt accgcatctt ctagctgcat 2616481 ttgtgcatca ctatattctt gatcgttata atgctcttgt ttagaagcga ttttcagctg 2616541 ttcttcagca taatcatagg cctgcataca ttgctggaga tgttcatcta ctgattgtct 2616601 tgttgccaca gtaacccctc ctcttggtaa tggaaatcat ccatcattca tattgtagcc 2616661 tcatctgact ttattcaata aagtaattta tggtcgatat tcatttgttc tcttgtgaaa 2616721 tgcgtgctac aattttagga tgcaatcgta cgcaaggagg cacatgaatt gtgatgcaga 2616781 acaatccttt tccttattca aatacggaaa aacgctatca tacattgaat tatcatctca 2616841 gagaacattt cggccataag gtgtttaaag tagcgcttga cggcggtttt gactgtccaa 2616901 atcgggatgg caccgtagcc cacggaggct gtacgttttg cagcgcagca ggctccggag 2616961 attttgctgg aaaccggacc gatgatttaa ttacgcaatt ccatgacatc aaaaaccgca 2617021 tgcacgaaaa atggaaggac ggcaagtaca tcgcttattt tcaggctttc acaaacactc 2617081 acgccccggt tgaggtgctt cgtgagaaat tcgaatccgt cctcgcctta gatgatgtgg 2617141 tcggcatttc gatcgccaca cgcccggact gtctgcctga tgatgtcgtt gattacttgg 2617201 cagagctgaa tgaacgtacg tatttgtggg tggagcttgg gcttcaaaca gttcatgaac 2617261 ggactgcact tttgatcaac cgcgcacatg attttaactg ctatgtggaa ggcgtcaata 2617321 aattaagaaa acacggcata cgtgtctgct cgcatattat caacgggctg cctttggaag 2617381 accgggacat gatgatggaa acggcaaagg ccgtcgcaga tttggatgtc cagggcatta 2617441 aaatccatct gcttcaccta ctgaaaggca cgccgatggt caaacaatat gaaaagggca 2617501 agctggaatt tctttctcaa gatgattatg tgcagctcgt ctgcgatcag cttgagatca 2617561 ttccgcctga aatgatcgtc caccgcatta caggtgacgg accgattgag ttgatgatcg 2617621 ggccaatgtg gagcgtcaac aaatgggaag tgcttggcgc cattaataaa gagctagaaa 2617681 atcgaggcag ctatcaagga aagttctttc aacggcttga ggaggaatca gcgctatgat 2617741 tttgaagaaa attcttcctt acagcaaaga actgctgaaa atggccgcgg gagagggaga 2617801 tattgtcgta gatgcgacaa tgggcaacgg acatgataca cagtttttag cggagcttgt 2617861 cggtgaaaac ggccatgtat acgcattcga catccaagaa tcagccgtgg ccaatacaaa 2617921 ggaacggctc ggtgacatgt atcaagcgcg aacaacgtta tttcacaaaa gccatgataa 2617981 aatcgctgaa tccctcccgc ctgaaacaca tggcaaagtg gcggccgcgg tatttaacct 2618041 cggctatttg ccgggcgggg acaaatcaat tacgacaaac ggcagttcta cgatcaaagc 2618101 cattgaacag cttctcagca tcatgaaaga cgaaggtctg attgttctcg tcgtctatca 2618161 tggccacccg gaaggcaaag ctgaaaaaaa cgacgtgctc gagttttgcc gggacttgga 2618221 ccagcaaaca gcccgtgtat taacatacgg gtttatcaat cagcaaaatg acccgccatt 2618281 tattgtcgcc atcgaaaaaa aagctcagat cagcaaatga tttgagcttt tttctttgaa 2618341 tttttcatcc aggacatttt ttgaaatttc cggtaggctc tgccgttgat ataaaagaaa 2618401 agggaggttt ttccgctggc tttgatcagc ttctttgcga gccggacctg cttcgtctta 2618461 ctttaccatt tttcaaatta tatttgaaag caataaccat cgttaacccg gacgtcatac 2618521 agttcgggtt tcgatttttc cataaaacgt tcacatatag catgaaacgt atgactttta 2618581 tcttatcaca aaactataaa cagcctctgc aaaaacacat acctattctt tcctgttctc 2618641 tattttctat gagcacacac aaaaagagcc cactgggagc tctttttgtc agctgatatt 2618701 tcgttcgctg gcagcagccg catttttttt atgaaaccct tttccatagt acacagccag 2618761 caagatgaga aaccatatcg gcccgataat cacggctact cttgtatcag ggctgtaagc 2618821 cataagaatg acgacgaatg ctagaaatgc caatgacaca taagacgtaa acggaaataa 2618881 aggcattttg tactttaatt gtttcttttc ttccggcttc aaacttttcc tgtattttat 2618941 ttgagaaagc aaaatgattg cccacgtcca aatcgctccg aacgtcgcaa tacttgtaac 2619001 ccaagtaaat accttcgcag ggacaacata gtttaacagc actccgacta ataaagcgcc 2619061 cgctgaagcc agaacagctt tacccgggat gccgcctttc gtcagctgac catatgcttg 2619121 tggcgcctct ttctgttccg ccaagttaaa cagcatccgc cctgtgctga aaataccact 2619181 gttgcatgaa gacagcgcgg ctgtcaacac gacaaagtta atgatacctg cggccgatgg 2619241 aatgcccact ttttgaaatg tgagaacaaa tggacttcct tgagagccaa tttcctgcca 2619301 cggataaata gacataatga caaataaagc gcctacataa aaaatcaaaa tccgccaaaa 2619361 tactgtatcg attgctttgg ctaacgattt ttgcgggttt tttacttcgc cagccgtcac 2619421 cccgatcatt tcaatcccta aataggcgaa catgaccatt tgaagagaca ataaaacccc 2619481 ttttaatcca tgagggaaaa atcctccgtt gttccacaaa ttgctgattc cggttgcaat 2619541 gcccccattg ccgactcctg caataatcat caataaaccg acagcaatca tggataagat 2619601 tgcaacaatt ttaatcaatg cgaaccaaaa ttccagctcg ccgtaagctt tgacagccag 2619661 gaaattaaca cccgtcataa tgaccagtgc cgataacgcc caaatccagt ttggcacgtc 2619721 cggaaaccag aaccccatat agatgccgac agcagtgatt tcggccatac aggtgacaac 2619781 ccataaaaac cagtagttcc aacctgttaa atagcctgca agcggtccca aataatcacg 2619841 cgcatacctg ctgaaggagc ctgcgaccgg tttttgaatg gccatttccc caagcgctct 2619901 cataataaaa aacatgacca ggccgcttgc ggcatacgct accaaaatac caggccctgc 2619961 taattgaata gctgatgcgg agccgaggaa caaccctact cctatagcag ctcctaaaga 2620021 cattaaagaa atatgccttt cttcgagtcc gcggtgcagc tcttgttttt gtttttgcat 2620081 gcttcttctc ccctagaaaa aaatatcatt atatcatttt tctgaatatt ccgtacggat 2620141 tgggtaaatc aatgatgatg gagaaataaa aggataacaa caaggctttc gactactcga 2620201 aagccttgtt gtctgttaca caaagatgac ttctttaggc tgatggctca gctcttcagg 2620261 catataccgt ttttcaatat tgatgctgtg ccagatcata aagattagca cagtccaaat 2620321 tttacggctg ttatcagcct tgtccgcaca atggtcttca agaagctgaa ggacataatc 2620381 cttatggata taagcatccg tttggctttc ttgaataata ttccgcaccc attcgttcat 2620441 ttcgtttttc agccaatgac ggatcggtac agggaaacca agctttttgc ggtttaatac 2620501 gtgctcaggc acaattcctt cagcggcttt gcgaagaaga tacttcgtcg tgccgttctt 2620561 cgttttcagc tcatcaggaa tttttgaagc gacgtcgaat acgactttat ccaagaacgg 2620621 cacacgcagt tccaaagaat tcgccatcgt cattttatcc gcctttaaca aaatgtcgcc 2620681 gcgcatccaa gtgtggatat cgacatactg cattttgttg atatcgctgt acgagctgct 2620741 ttctgtaaag taagtcttcg tcacatcgcg atatgaaagg ttcggattat aatgcttcaa 2620801 cagctgcttt ttgacagact cttcaaagat tttcgcgtta ccgatataac gatcctgaag 2620861 cggagtgcag ccgcgctcaa gcaggctctt ccctctcata ccttcaggca taacggcagc 2620921 aacgtgcaga agcatctttt tcaagccgga cggaatccgt tcaaacggtt taagcgaaag 2620981 cggttcacgg taaatgttat atccgccgaa gagctcatcc gctccttcac ctgataaagc 2621041 aaccgtaaca tgtttttttg cttcttttgc aacaaagtac aacggaatcg ctgccggatc 2621101 agcaagcggg tcatcaaaat gccatacgat cttcggaagc tcattcatgt attcctcagg 2621161 cgaaatgact ttgctgatat tttcaatgcc cagcgccgct gccgtttctt tcgctacatc 2621221 aacctcactg aagccctgct gttcaaagcc gacagagaat gtttttaagc ttggatgaaa 2621281 ttccttcgca acagacacaa taaaggaaga atcaatcccg ccagacagga acgaaccgac 2621341 aggaacgtca cttctcatat gaacgtttac agagtcatag atcgcgtctc ggacttcttt 2621401 cacaagcttg tcttcttcag tctgaaccgg cttgaagttc gctttgaaat acgttttgaa 2621461 tgtgatatcg ccgtccgggc ggattgtgaa ttgtgaaccc ggctctactt ttttcacatg 2621521 ggcatcaagc gtgcttggtt caggaacaaa ttggaaagac atgtactgct gcaatgcctc 2621581 tttatctatt tcaatatcat tctgagcaac cattaaactt tttctctctg aggcaaaata 2621641 aacctgatca ttgatcgttg tgtagtacaa cggtttaatg ccgaatggat ctcttgcccc 2621701 ataaagcaca tgatcgtttt tattccaaat cagaaaggca aacataccgc gcagtttgga 2621761 cgccgcttct tctttatagt gacggtaagt cgcaagaaga acctctgtgt ccgaatccgt 2621821 gttgaatgtg tacccctttg cttcaagttc ttctctcagt tcgatatagt tatagatttc 2621881 tccgttaaag ataatccaat atgtttcatc ttcatatgat aaaggctgtc caccattttc 2621941 tacatcaata atgctgagcc gtctgaatcc gaagccgacg tgctcatcat ggaaatatcc 2622001 atcactgtca ggaccgcggt gaacgatcat ttggttcatt tgtttgatta gttcttcttg 2622061 atcagcggtt tgagctaacg gatgcttgtt aaaaaccccg acaaatccac acatagtatt 2622121 gcctccataa ttaaaattgt catcattgaa cccctattta tagacgctgt gaatagtatt 2622181 tggtttcaca gttatgtaaa aaaataaaca tgaatacaac gataaaaaag ggaaagccgc 2622241 ttaaccagta agcggctata aaattattct cctaacgctt ctttacgcag ctgctccgct 2622301 ttgtctgtgc gctcccatgg aaggtcaaca tcgtgacgtc caaagtggcc gtacgcagca 2622361 gtttgtttat agatcggacg gcgcaaatca agcattttga taatgccggc aggtcgtaaa 2622421 tcaaagttat tgcgaacaac ttcaatcagt ttttcctcag aagcttttcc tgaaccgaat 2622481 gtgttgattg agattgacac aggctgtgca acaccgatcg cgtaagcaag ctgtacttcg 2622541 caagaatcag caagctcagc cgcaacgatg tttttcgcaa cgtatcttgc cgcataagct 2622601 gcagaacggt ctaccttcgt cgcgtcctta cctgagaacg cgcctccgcc gtggcgtgca 2622661 tagccgccgt acgtatcaac gatgattttg cgtcctgtaa gtcccgcatc cccttgaggg 2622721 cctccgatta cgaaacgtcc tgtagggttg atgaaatatt ttgtttcttc atcaatcagc 2622781 tcttcaggaa caaccggatt gattacatgt tctttaatgt tgcgctgaat ttgctcaagt 2622841 gtaatttcag ggtgatgctg agttgaaata acaatcgcgt caatgcggac tggtttgtta 2622901 ttttcatcgt actcaaccgt tacctgtgtt ttgccgtcag ggcgaaggta cggaagaata 2622961 tcttctttac ggacttcact taggcggcgg gctaatttat gggcaagtga aattggaaga 2623021 ggcataagct ctttcgtttc gttgcacgca taaccgaaca ttaatccttg gtcacccgca 2623081 ccaatcgctt caatttcttc gtcgctcatt gtgccttcac gggcttcaag cgcttggtct 2623141 acgcccatcg cgatatcagc agactgctca tcaattgatg ttaaaaccgc acaagtttcc 2623201 gcatcaaatc cgtattttgc acgtgtgtat ccgatttctt taatggtttg gcgaaccgtt 2623261 ttcggaatgt caacatacgt agaagttgtg atctctccgc ttacaagaac caaacctgtt 2623321 gtcacagatg tttcacaagc aacacgcgcg ttagggtctt tctttaaaat ttcatctaaa 2623381 atgctgtcag aaatctggtc acagatttta tccggatgcc cctccgtaac agattctgat 2623441 gtaaataaac gacgattttt actcatgatt tgcttcctcc tgcacaaggc ctcccgaaag 2623501 accttgtata tatgatacgg aactcgctcc ctcttataca atgtacagtt atattagaga 2623561 atgttaattg gcatatttat gaaataaaaa aaccttttcc atcgaggaaa gggtttggtc 2623621 tttgtgcctt tcactcttat cgctcaagga atcatacaac cttgcaacag gttagcacct 2623681 tggttgtctc actcagttga acataataaa taacagagaa accggttgct gggcttcata 2623741 gggcctgtcc ctccgccagc tcgggataag agtatccgct caatgaaata tcttatcgta 2623801 aaagggtttg caatgtcaat atgattcaga agaaataggc acctatattg agggaaaaca 2623861 atggaaatgc acacacaaaa aacaataaat agtatagact atttgaaaat atatgttata 2623921 ctaattcaca attagcaaaa cacaaaaaac gataaaggaa ggtttcatat gaactcagtt 2623981 gatttgaccg ctgatttaca agccttatta acatgtccaa atgtgcgtca taatttatca 2624041 gcagcacagc taacagaaaa agtcctctcc cgaaacgaag gcattttaac atccacaggt 2624101 gctgttcgcg cgacaacagg cgcttacaca ggacgctcac ctaaagataa attcatcgtg 2624161 gaggaagaaa gcacgaaaaa taagatcgat tggggcccgg tgaatcagcc gatttcagaa 2624221 gaagcgtttg agcggctgta cacgaaagtt gtcagctatt taaaggagcg agatgaactg 2624281 tttgttttcg aaggatttgc cggagcagac gagaaataca ggctgccgat cactgtcgta 2624341 aatgagttcg catggcacaa tttatttgcg cggcagctgt ttatccgtcc ggaaggaaat 2624401 gataagaaaa cagttgagca gccgttcacc attctttctg ctccgcattt caaagcggat 2624461 ccaaaaacag acggcactca ttccgaaacg tttattattg tctctttcga aaagcggaca 2624521 attttaatcg gcggaactga gtatgccggt gaaatgaaga agtccatttt ctccattatg 2624581 aatttcctgc tgcctgaaag agatatttta tctatgcact gctccgccaa tgtcggtgaa 2624641 aaaggcgatg tcgccctttt cttcggactg tcaggaacag gaaagaccac cctgtcggca 2624701 gatgctgacc gcaagctgat cggtgacgat gaacatggct ggtctgatac aggcgtcttt 2624761 aatattgaag gcggatgcta cgctaagtgt attcatttaa gcgaggaaaa ggagccgcaa 2624821 atctttaacg cgatccgctt cgggtctgtt ctcgaaaatg tcgttgtgga tgaagataca 2624881 cgcgaagcca attatgatga ttccttctat actgaaaaca cgcgggcagc ttacccgatt 2624941 catatgatta ataacatcgt gactccaagc atggccggcc atccgtcagc cattgtattt 2625001 ttgacggctg atgccttcgg agtcctgccg ccgatcagca aactaacgaa ggagcaggcg 2625061 atgtaccatt ttttgagcgg ttacacgagt aagcttgccg gaaccgaacg tggtgtcacg 2625121 tctcctgaaa cgacgttttc tacatgcttc ggctcaccgt tcctgccgct tcctgctcac 2625181 gtctatgctg aaatgctcgg caaaaagatc gatgaacacg gcgcagacgt tttcttagtc 2625241 aataccggat ggaccggggg cggctacggc acaggcgaac gaatgaagct ttcttacact 2625301 agagcaatgg tcaaagcagc gattgaaggc aaattagagg atgctgaaat gataactgac 2625361 gatattttcg gcctgcacat tccggcccat gttcctggcg ttcctgatca tatccttcag 2625421 cctgaaaaca cgtggaccaa caaggaagaa tacaaagaaa aagcagtcta ccttgcaaat 2625481 gaattcaaag agaactttaa aaagttcgca cataccgatg ccatcgccca ggcaggcggc 2625541 cctctcgtat aaaaaacaaa agccaagagc aattatgctc ttggcttgtt ttaattgacg 2625601 gaatgcaaag aagtcagctt gtatgtaatg atggtccggc cttcttccca ttgaagcttc 2625661 tgcacttcag ctgtgcctga cttttcgcca aactttgttt tgcgtacatc cattggaatc 2625721 tccatcggat atactcggta tccgtccttc tctaacgtga atatattttc atctatgcga 2625781 acttcttttc cttttgtcac aatcagtgta ttaaattcaa caggcattcc caaagtgaaa 2625841 tcccctttcg ttctcttttt tctttatcat aacatatttc actgtcagcg gtttttcatc 2625901 cattgtgtga gctgccgcac gatacgccgg ttttcttttg gcgggaaata atgtgtgaat 2625961 gtactgtagt accatgtttc caccggctta tgcagttgtt ttagcttctc ttctaataaa 2626021 taggaatgct gaatcgaaac attttggtct ttttctccat ggattaacag cacgggagcc 2626081 tgaattttgt ttacttggtc aaacggtgtc ctccattgat attcctcagg cacctttttc 2626141 ggtgttccgc cgatgactct tttcatcatt cgccgcaaat cctgccgctc ctcgtatgta 2626201 agaatcatat cactgacgcc tccccaggaa acaaatgaag ctgcctgccc gcccatttcg 2626261 atcgcagtga gcattcccat aattccgccg cgggaaaaac cgaagatatg gattctatcc 2626321 ttcttgacat ttgggtgctg ctgaagcagg cgaaaagcag aaaatgcatc ctccctgtct 2626381 tctccggcaa aatcctcatt gccttctcct ccttgattgc ctctgtaaaa aggagcaaac 2626441 accacaaacc cttgggatgc aaactggata atccggcccg gccgaaccat gcccacgctt 2626501 ttaatcccgc cgcgcaaata taaaaatccg tcatattgtc ccggttccgc cggctcagcc 2626561 agaagcccct taacccgtaa tccatttgac agatagcaga tcgtatacaa acgcacatgc 2626621 tggcttggcg acggaaatct tcttttctct acaatcaaaa cagccgcctc cttttttcta 2626681 tatgctttcc ttactccaaa attacatccg gagaacctgg ttaggcattc acacattttt 2626741 atacccatca tacgatatgt aaagcaaaaa aggatattaa cttgatgcga aataaggagg 2626801 ttgtctatgt gaacagatgg ttaaggctgg gcttcgcctg tgtcggcagt atctttctga 2626861 tgttcgccct ggcggcttgc aagcaggaag aaacgctcac caaagtcaaa gtagctgaag 2626921 tgacccattc aattttttac gcacctttat atgttgctga gtctaaaggt ttttttaagg 2626981 aagaagggct tgatgtcgat gtgaatacga cctggggcgg agataaaacg atgacatcgc 2627041 ttctttccaa cggctccgac atcgcgcttg tcgggtcaga aacatctatt tatgtcgaag 2627101 cgcaaggggc taaagatccc gtcattaatt tcgcccagct gactcagaca gacggaacgt 2627161 ttcttgtcgc gagagaagat gttgaacact tcgactggga tcagctgaaa ggaaaaacgt 2627221 ttctcggtca gcgaaaaggc ggcatgccgc aaatggtcgg cgagtatgta ctgaacaaac 2627281 ataagattga cccgcataag gatatagacc tcatccagaa catagacttc gccaatattg 2627341 ccaatgcgtt tgcttctgga accggtgagt atgtacagct ctttgaaccg caggcttctc 2627401 tctttgagaa aaaaggcatc ggccatatcg tggcttcatt cggagaagaa tcaggagagg 2627461 ttccttatac gacttttatg gcgaaacaaa gctatttgaa gaaaaatgaa gacacagccg 2627521 tcaagtttac aaaagccatt tataaggcgc agcagtgggt tgaaaatcat tctgcgaagg 2627581 acatcacaga tgccattaaa gatgaatttg atgataccga cccagacgtc atcgaaacat 2627641 ccattgaacg ctataaaaaa cagcattcat attcaccaga ccctctgctt aacgaaaaag 2627701 aatgggagct tctccaaacc attatggata aatcgggaga actgccgaag cacattccat 2627761 acaatcagct tgtaaataaa gaaattgctg aaaaagtcac ctcggagaaa taggaggcgc 2627821 catctatgtc tttcttacat gtcgaccatg taacccatac ttatttttct attaaagaaa 2627881 aaacaacggc tgtgcgggat attcatttcg atgccgaaaa aggcgatttc atctcatttc 2627941 tcggcccaag cggctgcgga aaaacaacat tgctttccat tattgccggt ttgattgagc 2628001 catcagaagg cagagttctg attgaaggcc gtgagccgaa tcaaaaagaa cataatattg 2628061 gctatatgct tcagcaggat tacttatttc cctggaaatc tatcgaggaa aatgtgcttc 2628121 tcggtttaaa aatcgccgac acgctgacag aagaaagcaa agccgctgca ctcggtctat 2628181 tgccggagtt cggcctcata gatgtggaga aaaaatatcc gaaagaactg tcaggcggga 2628241 tgcgccagcg ggctgcgctt gcaagaacac ttgcgcctaa ccctagtctg cttttgctgg 2628301 atgagccatt ttccgcgctt gattttcaga caaagctgtc tttggaaaac ctggtattcc 2628361 gcacattaaa ggaatatcaa aaaacagcag tgcttgtcac tcatgatata ggggaagcga 2628421 tagcgatgag cgatacgatc tttttatttt caaatcagcc gggcaccatc catcagattt 2628481 ttaccattcc taaggaattg gccgcgatgt tgccttttga cgcccgtcag gaaccttcct 2628541 tccagacact gtttcaaacg atatggaagg agctgaattc tcttgagaaa cagcaaagaa 2628601 accattgatc tgcttcacga gcagtatcaa ttcaaacaga aaaaggaaaa gtggaaggtc 2628661 cattcctttc agcttgccat atttattctc tttttctcgg gctgggaaat ctccagcagg 2628721 cagggctgga tcgatccgct gatcttcagc tctccatcag ctgtgtggcg attattgctg 2628781 gagaaacttg gtgacggttc tttactgtca cacatcggcg tcactttatt tgaaacggtg 2628841 cttggctttt tgctcgggac gtttatgggc acgtgcctag ccgctttgtt atggtggtct 2628901 aaccgacttg ccagaatttt agatccgtat cttgtgattt tgaacgcaat gccgaaagtg 2628961 gccctgggcc cgatcctgat tgtcgcgctc ggtcccagtt ttatcagcat cattgcgatg 2629021 ggagccatca tcagcgtcat tatcacaacc atcgttgtct acaccgcctt ccaagaggtc 2629081 gacgaaaact atacgaaagt catgaaaaca ttcggcgcaa aaaagtgggt tatttttaaa 2629141 gaagtcatac tgcctgcatc ctcccccgcg attatttcaa cactaaaagt gaacgtcggt 2629201 ttatcatggg ttggcgttat tgtaggggaa ttcctcgttt cgaaggtcgg attaggatat 2629261 atgattattt acggattcca agtcttcaat tttacactcg tcttcttaag cctgctgatc 2629321 atcgccatct tcgccactct gatgtatcag ggcgtcgagc tgctggaaaa gaaatggacg 2629381 aaggggagga cataaaaaac ccggcacatg tgccgggttt tttattcaat ccatccagat 2629441 tctttcagtt ttttcaagct gatcggaaga acggaatcct tcataataaa gctgaatttt 2629501 ttattgcggg aaaggttctc cggcagctcg tgaaacaaaa ccgggccttt cgtttcaaag 2629561 taatcagcct gcttttcaag cttttctata tctgcaaaat atatattttt tacaatcact 2629621 ttttcttttc cgagaacttt atactgtccg agatacttga ggcttttgac tctcgcgccc 2629681 gtctcttcct ttacttcccg gagcgcagcc tcttctgcgc actccatcgg ctctactttc 2629741 ccgcctggaa actcatagcc tctgtcctca tgttctgtta aaagccattt gccgccaaaa 2629801 cggcaaatca cccagacatg cttcgggctg tccgagaaag gctgatcgtc aaaggaaagc 2629861 tgaacagtat tctgataata atctttaaac tcgtacatgt ttatccctca aatccgttcc 2629921 tagctatctt ccatacatca taccacagtt acgtttcttc ggaagccttt tatcaaaaaa 2629981 taagggaaac ccagcacgcc gtcaggttct gcatgcagac tagctcgtac agtttttttg 2630041 cgatactttt gccggaaagt gcgaccgacg ctctgggctt tattatgacc cgcgaacagg 2630101 gaaaagttac ggtttgcgct taaatttatt ttttaacgtt tctaaaagat cgacaagcat 2630161 ctgaggaacc ggtatgccaa gagagctggc tgtcacaaca atttgcacag attcataaag 2630221 aatataaaac ataatagcca agtcacgaat tgatccctgt gtattcagca gctgatcaaa 2630281 aaagtggcat acagagatca gagccagcgt gactaatttt ttgacaagcc gggcaaatac 2630341 ctttttaaat gacagtttgt gaataatggt ttccttcaaa gtcgtactga taaattcaat 2630401 tgccataaga gagagcaaaa tcagaaatga atactgaaaa cctccaaaga aaaaacccgc 2630461 tgctgaaacg ctgactgcta aaaacgaaaa gatgccaaag tctctatcca tttatcccaa 2630521 catcctttca cagaaacggc cttacgatat tctatggtaa acaagccgaa cggattggat 2630581 ttttcagaaa aatggactgg ttgtcgccta tttttcagat acaaaaagaa aagccggacg 2630641 tcttttttaa gacatccggc cgttctattt ttgaacttaa cctaggtaag cttttagcat 2630701 ccagttatgt ttttcaatat tttgatggat cgcaagaagc atgtcccctg ttgtttcgtc 2630761 accgacttca tcagctaaat ccatgccgtt tttcagctct tccgcgatga ctgtgaaatc 2630821 atcatatacg ctttgaacca tttgttcagc tgtttcattt ccagcagctt ctttgacaga 2630881 agccgtttct aaggattcct tcattgttgc aatcggtttt ccgttcagcg ccaaaagacg 2630941 ttctgctaag tcatcaatat aagttgctgt ttcgttgtac agctcctcaa acttttcatg 2631001 aagagtgaag aaatctttcc ctttcacata ccagtgataa ttatgtagtt tcacatacat 2631061 gaccgtccag ttggctactt gtttgttcac tgcttgaatc aattgttctg acatggtatc 2631121 tcctccttgt tatatgacta tgtataccct taatatcgta cgctaaaacc tcttttttac 2631181 ccttatctgt cacgatttct tctattatgc tacaattgtt aaaaaacggg aggtggaatg 2631241 tcatgacgct tctcattacg ataagtattt tgattgtgct ggctgttttg cttgtaacca 2631301 tttggacgac tgtaaaagcc tataatgtaa agcataccat tgatccacca caagaaaatc 2631361 actctgattc acacaatcaa tgatgatgtg aatgctcctc ttctgactga ttgctggcag 2631421 catcggcgtc tccgacttgg acttttaagg tcggcatgct atgctgtttt tttgctgtga 2631481 catgagattg gacagtgtat acaccatctt ccttaaacgt cgtttccaat cggtatacgc 2631541 ctttttcttg tttcacctta aacatttggc ttgcgtcttt ttccccttct ttccatactt 2631601 caaactctac ttcatcggca tccgtcacag cttcatcacc atatgataca gctgcttcat 2631661 aagcagcgct ttctccggga tttacttttt caggcccggt cagcttgaca tccaaaacct 2631721 cgggcgtctc agctgtattt gctttacttt caccagatcc gcatccatta agcaataaag 2631781 cagaaaaaag cagaacaacc aacatctttt tcatgccatc accctttcat cgtttaccta 2631841 aatagtagca aacgcttaca gcaaatggta cacaaaatat gagacgtcac aaaaaagacc 2631901 tttttgctta agcgcaaaaa ggtcctttct attttagcca aatactttta gcaattcttc 2631961 tttatcctgt gaaagccaga aacgcattaa acgtttagcg ccttccagat catgaagctt 2632021 cgcttggccg cactgctttt cattcgcagc aggtatttct gtaatctcta ccgcttcctt 2632081 cattgtgtct tcaagcagat caacgatttc cgctgatgtc ggctctccgc tcacaactag 2632141 ataatagcct gtctggcagc ccattggaga aatatcaatg atatcaaaat gatcgtattt 2632201 ctcagcgtga gaacgaatcg taaacgcgag caaatgctcg agtgtgtgaa tggtgtcagg 2632261 cttcatcgcc tgtttatttg gctggcaaaa acgaatgtca aatttattta caacgccgtc 2632321 tgttcccact ttatgcacgc cgcaatgtct tacatatgga gcaacaaccg cattatgatc 2632381 aagctcaaaa ctttctactg aaggcataat ggcactctcc ccttttttaa aaatgtaatt 2632441 tcattataac atacttttcc gataagaatt attgattaac ttttcaatct gtgttttttt 2632501 tcttatactt gcatcagaaa ggttgctgaa gaaacatgaa aaccctattc atcgctctga 2632561 tcagaggata tcaaaaattc atctcgcccc tgacaccgcc aacgtgccgc ttttatccga 2632621 cctgttccca atatggaatc gaagcgatta aaacacatgg cgctttaaaa ggcggatggc 2632681 tgacaatcaa acggattttg aaatgccacc cgttccatcc gggaggagtc gatcccgttc 2632741 ctgaaaagaa acaaaaacat taattgttat aaccgtttac gataagatcc agttttccgg 2632801 ttttaggatc aatgactaag ccatggaccg gaacgttttc agggaacagc gggtgatgtt 2632861 taataacatc tacgctgtct ttcacactcg cttccactga atcaaagctt ttaaaccatt 2632921 gatcaaagtc tacaccggag tactttattg tttcgatgcg ttcttccgga atccctcttg 2632981 ctttgatttt ttcaagcatg cttttgctgc tgattttgct catgccgcaa tcgtgatgcc 2633041 cgatcacaca cacctcatct gcattcagct cgtacactgc gacgagtata cttctcatga 2633101 tgcttccgaa tgggtgtgtc acaagcgcac cggcactttt aatgattttc acatcaccgt 2633161 ttcgcaaatt catcgcatgc ggcagcagtt caaccagacg agtatccatg caagaaagaa 2633221 tcgccatttt tttatctgga aattttgatg tttgatactt ttcatactct ctttgttcag 2633281 taaatgtctt gttaaattcg agaatatcat ttagaagact catgttcgtt gtccctttct 2633341 attcttttta ctcttcaata tatcacaacc cttgtttatt cgtcataata aaaaaagaca 2633401 aaccctcagg cctgccttat ttccccatgt tatagcgttt tttgaactgc tcaactcgtc 2633461 cgcctttttc attgaatttc tggcggcctg tataaaacgg atgcgtgtca gagcttacct 2633521 ctactttaat gacaggatat gtgtttccgt cctcccactc tgctgtttca ttagatgttt 2633581 tcgtagaggt gcttagaaaa cggtagccgc tgttgacatc ctgaaatatc actttgtggt 2633641 tctttggatg aattccttct ttcatgggta tctcctttca ataaatcgta ataattacgt 2633701 tttattttat aaccttacaa acgttttgtc aatcttctta tatccttccc tctgtttcac 2633761 atcgtaaacc tcatggcatt taagaatagg aagaataatc taaccgagga agcaaataat 2633821 aaacccaaaa tacatacaga acgtcttttt ggaaaggtgg tttacgattg tggatgattt 2633881 agttttggcc agaagccttt ttggcacgac gatgggcttt catatcattt tcgcaacact 2633941 tggagtcggt ctgccgctca tgattttagt ggcggaattg atctatcaaa aaacgaaaga 2634001 tgaccattat gcgatcatgg cgaaaagatg gacgaaagca caagccgttt tgctgggggt 2634061 cgccataccg accggaacga tcgcgggcac tcagctcgcg cttttatggc cgggatttat 2634121 ggaagtcatc ggccgggtga tgtccctgcc atttcaaatt gaaatctatg ctttttttgt 2634181 tgaagcccta ttcatgtcga tttatgtata cgctgcagac cgtttgtcac ctgcaatgag 2634241 gattgttgct gttttctttg tgttagtcgg ggcagcagca tccgctgttc tgatcacgaa 2634301 tgttcacgct tttgaaggta cgcccgccgg ttttaaaatt ttaaacggaa aaattacaga 2634361 tgttgacccg tgggctgcgt tttttaatcc tagctttttt atcactgccg gccatgtcgt 2634421 gctgtccgcg tttatgactg gtgcgtttat cgtggcttct gttgcggcgt ataaaatgat 2634481 ccgaacgagg aaaaaggaaa gggtctatcg ctttcaccgg aaagcccttt tgctcgcact 2634541 gacgatcggc ggtatttttt cattgctgac cgctttgaac ggacacgaat ctgcacagat 2634601 gctgtacgaa taccagcccg aaaaattagc cggtgcggaa ggcctatttg aaacaagatc 2634661 ccacgccccg ctcgctatcg gcggttttac cgacccgaat gaagaaaaag taaaatgggc 2634721 aatcgagatt ccatgggctt taagcttttt ggcagcgaac cgttttgaca ctgttgtaaa 2634781 aggattaaat gcatttccga gagatgaatg gccgccgctt ttcattcaca cgctgtttaa 2634841 tgcgatggtt ggtgtaggca tgctgctaat tctttattcc attatcggtg tggtctggag 2634901 aaaggtgctc aagaaagacc gtttcccaac gtggcttttg atcattttca tgacagcagg 2634961 cccttttagt ctcatcggca ttgaattcgg ctggattttc gcatgtacgg ggaggcagcc 2635021 ttgggtcatc tatcatctgc tgaaaacgtc agatgtcgta acaacgactg gctcgatcgg 2635081 ggtgctgttc ttatttttca catttgttta tgccgtgtta ggcgcagctg tcgtctacgt 2635141 gctgctgtat tatttccgca agcacccggt tgacgaagat ttaaatacag cggagtcgta 2635201 atggctccgc aaacaggaaa ccaaatggaa ggaagatcgt acaaatggag atttcaactg 2635261 acgctctgat cgccatctca attatctggg gctttgtgtt tatttacgcc gtcatggcga 2635321 caatggattt tggagcggga ttttggtcta tgatctattt aaacaaggag catatgaagg 2635381 ccaccgatat tgcgaatcgc tttttgtccc cgacttggga ggtcacaaac gtctttattg 2635441 tggccatcgt cgtggcgctt ttcagttttt tccccggcgc gacatttgtg ctcggcaccg 2635501 ttttattaat tcccggaagc atgattttgc tgcttttagc aattcgaagc ggatttctcg 2635561 tgttttcaaa tacagcaaag gagcggaaaa cgctaagata tatttccggc atctccggct 2635621 ttatcattcc tgctatttta attttggtgc ttcctgtgac acacggaggg tttatagaaa 2635681 aaacggatgg aatctataac ttaaatatgt ctaaaatctt ttcaagcccc aacgcctatt 2635741 catttatcgg gtttgcgatt ttaagcacct tatttttgtc ctcgctgttg cttgcagatt 2635801 tttcaaatgt ggcagaggaa caggatgcgt accgagccta cagaaaaagc gccctgatta 2635861 ccggcccgat ttcactgttg tttgctgtat gcattatggt aactatgcgg aatgaagcaa 2635921 actggctgta cagcggaatg atgaatgatt tttcttggat tattgcatcg ttcattacat 2635981 ttgtcattgc tggaatcgct ctttttctgc ctaacaaaag ctttggtcaa aacatcggaa 2636041 aaccgcgtct cgcacttgtt gcgattggga tacagtattt tctcgcaagc tacgcgtacg 2636101 ggcgggcgca tcttccgtat atgatttatc ccgatgtgac agtcatgtca ggcttcacag 2636161 agccagcaac gttcagagcg ctgtttgcaa cgtatatcgt tgcatttatc attctatttc 2636221 cgggcttctt tttcttctgg aaaatgttta tgcgagataa acgctatatc cgccaggagg 2636281 aatagagggc aagccagccg gctatactaa tccagaacct ttataaggag gggatggcat 2636341 ggagcagaaa attctatgtg aggtcaacaa ctgttcttat tggggcaaag gtaacaaatg 2636401 caccgctgat gccatttatg ttgtcagcca tactggtgaa acggctgaaa acagccggga 2636461 aacagactgc aaaacgttta agccgcatga tttataatta aaagaaagag ctgcatcagc 2636521 cagctctttc tttttgcatg ttgagtgttc tcagcttttt agttatgacc ccgtttgcag 2636581 gtgaaaacaa aaaggcgctt gcataacata cacctgtcat ggccgccatc gctcctgaaa 2636641 tcgaaacatt aagccacgtt gcgaagaaat agcccatgac cgccgacagc ccgccaatca 2636701 acgcgctgag aatcagcata taaagaagcc ggtctgtcag caaatgtgcc gcagccggcg 2636761 gaacaatcag catggccaca accaatacgg cacccaccga atcaaaggaa gcaacagtcg 2636821 tcaaggacag catgcccatt tgcacgtaat gaatgagcaa aaccggtatt cccaaggcta 2636881 aagccatttg aggatcaaac gaagcgattt taaactcctt atagcacaca ctgatcaaca 2636941 ctacgtttaa aaccagaaca gatgccagca tccaaaacgc tttcggccca atatcaaccc 2637001 cgaataccgt caccgtattc cacggcacaa aagcgatttc tcccattaac gagtgctcaa 2637061 tatcgagatg gacattcgct ccatacacag aaagcaaaat aaccccgatt gcaaataagg 2637121 atgtaaacac aactcctatg gcagcatctg attgaacccc cttgctatga agaagctgaa 2637181 ccaagaaagc cgttaacaga ccggttgcgg ctgcgccaat aaacatataa atcccatcga 2637241 gacttcccgt cactagaaaa gcgccgacaa tgccaagcaa cactgtgtga ctgattgcgt 2637301 cggccagcat cgccatgctt ctcagcacaa gaaatgtgcc gatcaatccg cagcttacac 2637361 cgactaatac accggtagct ataatccatg cttcaaaact catttgcgat ctgtcccttc 2637421 tcggcatcat gagacgcttt tcgacgctca ggcatccgtc catacagctt taagagtgaa 2637481 taaagccgct ctctcgtttc tctcggtaaa cggtccgggt caaagtagtc ctgatcggat 2637541 tctatattgg caagttccat ttcatgcatg agatacactt catacatccg ctgcttcaaa 2637601 gctgtgtgat agcctttttc tatccctttg cttgtgattt gccaaatccc attttcgata 2637661 cgctcaatgc acctctcttg ttccaagtca tttaatgcct taaggcataa tgaaggggat 2637721 aggcgtcttt tctttcttac actttcaaca gttacacaaa gattattctt ttcatactgt 2637781 tcataaatcg ccaaaagcac ttgctccctg cttgttctgc gccgcagcct catcagcctt 2637841 atggctttag cagccaatcc ccgcttaggc gcgcaaatca ttgaaaaaag aaagagcagc 2637901 gttgcagata agatcattaa tggccctgtc gccattccct tcatcgtggt gctaagcagg 2637961 gttccggcca ctccgctgac cccgcctgta atcccggcaa tgatgatcat cccggttaat 2638021 cgttcggtcc aatatctcgc ggttatggca ggtgtaatca gcatagccgc cattaatatc 2638081 acaccaacag tctgaagccc aatgacgaca gcacagacaa tcagacaagc caaaagcccg 2638141 tttaaaaaac gcaccgggat tcctaatccc tttgcaaacg cgagatcaaa agtaatcaat 2638201 gtaaattcct taaagaaaac aatacatagg agcagtagaa cagcggatat ccctgcaata 2638261 aggatgatat cctgcctgac caatgaagca gcctggccga ataaaaaaga atcaagcccg 2638321 ctttggcttc ccgccccctg ttgctgaata tatgtcagca gaatgatccc gacgccaaaa 2638381 aacacagaaa gaacaatccc gatcgccgag tcctcctttg tttttgaaag ccgaggaatc 2638441 agctgaatac aaaacgttcc gagcagtccg gcgagcgctg cccccagcaa aaagaaaggc 2638501 agtgattttt gcccggtgaa cagaaaagcg agacacactc ccggcagagc tgaatgggcc 2638561 atcgcatcgc cgattaaact ttgctttctc agcagcacaa agctgcccaa aacaccgctt 2638621 gccgtcccga gcaaaagcgt accggccagc acccactgtg tattcggatg ctgaagctgc 2638681 agccacaaac tttcaaacat tgcgctcact ccttatgtcc ttctgccagc actttatctt 2638741 ttaaaaacgt aagccttcct ccatatgttt tttgcaggtt ttcgatcgta aaaacgtttt 2638801 ccgtcggtcc gaaagcgatt ttccttaaat gaagcagtaa gatccaatcg aaataatcct 2638861 cggcggtctg cagatcatga tggacgacaa gcacggtttt tcctttttct ttgagttctg 2638921 ccaacagcgt cataatcgcg cgctccgtcg ctgcatcaac acctgcaaac ggttcatcca 2638981 taaaataaat gtcagcgttc tggcagagtg cccgggcaag aaacacccgc tgctgctgtc 2639041 cgcctgacag ctggctgatt tgccttttcg cataatcatg catcccgact tttgttaatg 2639101 cggccttcgc catctccaca tccgctttct ttggcctctt taataaaccg attctcccgt 2639161 atcttcccat taggacgaca tcgagcgggc ttgtggggaa atcccagtca accgagccgc 2639221 gctgcggaac atatccgatt ctggtccgct gatccttata gtctttgccg taaatagaga 2639281 tgtctccgga agctctgggc acaagaccga gaatcgtttt gatcaaggtt gattttcccg 2639341 cgccgtttgg gccgataatg ccaataagtt ttccttcagg cacctgcagc gaaatgtcct 2639401 gcagtacagg ctttttatga taagcaaccg tcacattatc aagctcaaca gggaacatat 2639461 cctccacctc ttttctttat ttaagcgctt tagtaatcgt gttgatattg tggcggaaca 2639521 ttccttcgta tgtgccttct tttgtgccct tttcacccat ggcatccgaa taaagctgac 2639581 cgccgattgt gactgtatgg cctttttctt tagcgccttc caccactgca ttgattgatt 2639641 tttcagatac actgctttct acgaacacag cttttatttg tttttctgtc agaagatcaa 2639701 ccagctcctg aacatccctt aatccatagt ccgaatctgt gctgagtccc tgcaggcctt 2639761 ttaccttaaa tccatactca ttcccaaagt acgcaaacgc atcatgagca gtcacaagca 2639821 cacggctttt ctccggaata tgtgcgatct ccttacgcga ccacttatct aaatattgca 2639881 aatcttcttt gtactctttg gcatttttcc gaaaggcatc tgcgtgctga ggcattgctt 2639941 tgctgaattg cgcttcaatt tcatccaccg catagatcca taacggaatg ctgaaccaga 2640001 cgtggggatc aaacgtcttg ccttcccccg cgggaataag cttatttttc ggaatggcct 2640061 cagctactgc cgccgattgt ttttgttcgc cgattttttg gaggacatcc tccattttcc 2640121 cttccaaatg caacccgctg tacagaacaa catcggcaga cattaatttt ttcgtgtcac 2640181 cttgggaagc tttgtaaagg tgcggatcaa cccccggtcc cattaaagag gtgactttta 2640241 cgtgcttacc tccgatgttt tctgctgcat cggcaatttg agatgttgtc gctgtcactt 2640301 gtaattgctg atcagcgctt tttccggctg aatccgttcc gcatcccgtt aaagcaaagg 2640361 tcgcaaaaag tactgctgcc atcagccctt gtctcatatt tctcctcctc tttgccatca 2640421 atgtccgatt gttttatctt atgttgtcag ttcttagaca tgtgacatta aattagccaa 2640481 aagcatgttt tatttacaca ggacaaaaag tttccctcat gcaaaattat cgcgtttggc 2640541 catttttgtc aagctgattt acataaaaaa accggctggg tcagcagccg gtccaaacga 2640601 gaagggatgt attcaacgaa cacttttact gtaacagcac agtgtcattt attcaaaata 2640661 gcaaaatgct tttttcttaa ccatgctgtg tgaaaacatc cattttggtc acatattttc 2640721 gcataatatc ttggtttacc tcaaccccta aaccaggctg ttttgacaca gaaataaatc 2640781 cattatcaat acgaatatca ggagttacaa tatcttcatc ccaatagcgt gaggatgaag 2640841 atatatcgcc aggtattgtg aattgaggca gtgaagcaag cgccacgttc tgcgctcttg 2640901 atatgcctgt ttccagcatt cctccgcacc aaacctgcat atgatgctct ttgcataaat 2640961 catgaatttt taaggcttct gttaagccgc cgacacgaga aggttttata ttaataattt 2641021 tgcagcttcc tagctcaatc gcccgtctcg catcatcaac tgaacaaatg ctctcatcaa 2641081 ggcaaatggc cgttttcaaa tgtttctgca agtggcggtg gtcaacgata tcgtcagctt 2641141 ggagcggctg ctcaatcatc attaaatgat agtcatcaag ctcctttaaa cggctgatat 2641201 ccttcagttc gtaagaggaa ttggcatcgg ccataagcgg gatggttggg aatcggctgc 2641261 ggatggcctt gaccaattcc acatcctgcc caggctgaat tttaattttt attctttgat 2641321 aaccttcttt ttgatagctc tcaatttcct tcagcatatc gtcaagaggc gccaggccga 2641381 ctaccacccc ggcagggact ttatctcttg ttccgcccaa tgcctcagca agggatacgc 2641441 ccttcttttt ggcataaata tcccatacag ccgattcaag tcccgctttt gccatccggt 2641501 ttcctttata ccgcgccagg ctgtccggca cttctgaagg gtgattgaat tcacggccga 2641561 cgacatttgg gataaaaaaa tcttttagca tatgcaaaca tgttccaatg gtttcctcgg 2641621 tgtaccaagg cgaagagaaa gcggaaactt ctccccagcc tgtgacacct gatgtatcaa 2641681 tggcttccac gatcagaaat ttacgctctt gaagcgtttc gatactgttt ttaaacggtt 2641741 tctttaagtt catgctcaaa tggtaaagcg tgattttttc tatttcgatc atagcagttc 2641801 tcctttacgc gcatccttca gctgatttcg caagagctta ttagacgcat tgcgcggcag 2641861 gcggtcaagc acaaagaatt ttgccggaat tttatacttc gccaagcgtt ctttgcagta 2641921 gtcagtcaat tctcctgcgc tcacaggctt gtgaaggaca agataggcgt gaggcacttt 2641981 cccccatttt ttgtcctcag cccctgaaac cccggcttcg gccacagcgg ggtgtgaaag 2642041 cagcactgac tccacttcgg ccggataaat gttttctccg ccggatatga tcagatctga 2642101 acgtctgtct aatacatata aaaagccttc attgtccaaa taaccaagat cacctgtttt 2642161 cagccagcca ttttgaaagg aggcttcgtt tgcgctctcc cggttaaaat agcttttcat 2642221 gacattcggg cctttgacca tgatttcacc gtgttcatac ggttcacata cctgtccgtc 2642281 ccgctctatt ttgatttcac acgaaaacag cggtttcccc gcagatccga gcttttccat 2642341 gctgaattcc ggcgacaggg taacaatttg cgagcatgtt tctgtcattc catatgactg 2642401 aaagacaggg aatcctttct cacggcattc ctcaagcaat ggcagcggtg caggaccgcc 2642461 gccgagaaga atgcatctga tggattcagg gcagcggttt gtttcttcca aaagactggc 2642521 cagcatagtc tgcaccgcag atatcattgt cacttcatgc ctgttgatag aatgcagcac 2642581 atcgcttacg gaaaaacgct ggtgaagcac gacagtcatt ccatagatca cagatttaaa 2642641 taatgcggac aatccgctga tatgaaagag cggcaatgcg ataagccagc ggtcttgttc 2642701 tgttataccc aaattaagag cggacgacac cgcactgaaa taatggtttc cgaacgtttg 2642761 ctgaactccc ttgggctttc ctgtcgtacc cgacgtatac atcagcgttg ccgttgcatc 2642821 catttgcata taagcctcga tctcaatttc ctctgctgct tctttcatca gttcatccac 2642881 atcaatcgtt tgaacgatgt gttcatattc tttcttctca aagcttgaat ctgtcaataa 2642941 aaagccggat cccgaatcct ccagctgaaa cagcctttca tgtgttgaca gcttcgtatt 2643001 caaaagcacc gccttaacac caagcaaaaa acaagcgtga acagcgtata ccatttctgc 2643061 acggttttgg agcaaaatag ctgcagtatc ccctttccga accgaatgag cggcaagctg 2643121 ttccgccatt cgtttagacg cggcaaacaa ttctgcaaat gtcacggttt ggtcttcata 2643181 gatgagagcg attctctcag gtgtcagctg tgcccgctgc atgagccagt tgggctgttc 2643241 tgtcagcatg tcatcatctc cgaggtaaaa tgtctgtatt gaaaagaaaa cagcttggac 2643301 cgcaaagtct caagctgttg gtttactaga tattgctgat cacggaaaac gagggaactg 2643361 tccgaaatca ggtttgcgtt tttccttaaa ggaatcacgg ccttcttttg cttcatctgt 2643421 tgtgtagtaa agaagggtag catcccctgc aaactgctga attccagcaa gtccgtctgt 2643481 gtccgcgtta aacgcagctt taagaaagcg cagtgcggtc gggctttttt caagcatttc 2643541 ttcacaccat ttaatcgttt cttcttcaag ctgttccaaa ggaacgactg tgttgacaag 2643601 acccatgtcc agtgcttcct gtgcgttgta ctgacggcat aggtaccaga tttcacgtgc 2643661 ttttttatgt cctacaattc gagccaggta gccagaaccg taacctgcat cgaagcttcc 2643721 cactttaggg cctgtttgtc caaaaattgc gttgtccgca gcaattgtca agtcacatac 2643781 gatgtgaagc acatggcctc cgccgatcgc atatccggac accatcgcaa caaccggttt 2643841 cgggatgacg cggattaaac gctgaagatc caatacgtta agacgaggga tctggtcgtc 2643901 tcctacatat ccaccgtggc cgcgcacttt ttggtctccg ccagaacaaa atgctttgtc 2643961 ccctgcaccg gcaagcacga taaccccaac gttttggtcg tctcttgcgt cagcaaacgc 2644021 atcaatcatt tcagcaaccg ttttaggggt aaacgcatta tgtacctcag gtcggttgat 2644081 tgttattttt gcaatgccat tatacgtttc atacaatatc tcatcgtatg tccgttttgt 2644141 tttccattca gccatatgat gacctccttt tattctctat gtgaatgagt cagatgcttg 2644201 tcaaaaactc actcactatt ttaccaaaca atcgcggctg ctccacatgg accgtatgtc 2644261 ctgcttttgg aacaatctct attctactag aaggaagcat cttatgcacc tcttgattga 2644321 tggcgcaaaa tttttcgtcc cactccccgc agatcagaag cacaggaaca tctatttcct 2644381 ctacacggct ccacaaggaa ggctgtgaac cggtgcccat gccggttaaa ctgttcgcaa 2644441 gcccaatctt attgttccgc agacggcccg atcgtatcct gtaccgaata tcttcagcca 2644501 gcctctgctg agatgaaaac aaagggatat tctcccaata cgcaacaaac gcttcgagcc 2644561 cgtctcgtaa aataaaatca gcaagcttcc ggtcccgcat gattcgttcc cgccgttccc 2644621 caagtgtttt gagccccggc gtcgtgcttt caagcacaag tgccgatacc cgctcgggat 2644681 atgtcatcgc aaaagagtaa gcaagccttc ctcccataga atacccaatc aatttcactt 2644741 tgtgaagttt taattgatca aaaatctcgg caaggtcaga aacttgccgg gttgtgctgt 2644801 atcttttccc attcagcggg gcatcggttt ccccatgccc taaacaatca attttgatca 2644861 aacgggaatc aggcagcatt tcatcaagaa aagtccatga ttgtttgctg ccggtaaacc 2644921 catgcagaca gacgacggct tcggaagcat tcggtccctc gtctgccact gcatatcgga 2644981 caccatctga taccgttatg tttacagttc ccattgtttt ttcacttccc gcacagcctc 2645041 attcagcata tcgcgatgaa gctggactct tgattggcga tccgttttga tttcaatcaa 2645101 atggagtccg ggcttgtctg cctgcggcgc gtaagctgtt ttgaattcat cccaagaagc 2645161 cgggcatgaa tacgttccgc cgtaaagtgc agccgcatgc ttgaaatcga gccctgtcgg 2645221 tgtgccgaac aaatcttcaa agtgtgtctt ctcagaagcc tgcggcaaaa aggagaaaat 2645281 ccctcctccg tcattattga caagaatcac agtaagagga atacccagct ttttggccgc 2645341 cagcaggccg tttaaatcat gataaaaaga taaatctcca atcacaaggg taacaggcgc 2645401 ttttgttcct tcacataccc ccatggcaga ggagacgaca ccgtctatcc cgtttgctcc 2645461 ccggtttgaa taaatccgga aagggcggtc ctgcttttca aaaaacgtat caacatccct 2645521 gatcggcatg ctgtttccca caaacagcga gctgttttca ggcacaagat gctgaaggat 2645581 tcgatagaga ttgccttcaa acgaaacatc ttcactgctg attgtttgca gatgctcgcg 2645641 gaaccgccca ttgacaaact gccacttttc cagccactct gaggatctgg tggcagcagt 2645701 aaggcctgcc atgatctcct cagcaaaaac agacgcatta caatgaatca tatgcgcgct 2645761 tgcctgtgtc gggtctctcc accctccatc ctcgtcaatc acgatttgct gaatcgtcgg 2645821 atcatcctta agccataaga aaaccggttt tgaaacaggc atcggtccaa accgaatgac 2645881 aacatcagga cggagtttcc gcttcagctc atcatctttt aaaaacgaat catacgcatc 2645941 aataacagtg cttttatcat gaacaccatt ccgcagatta gacagcggat ctgctaaaat 2646001 tggatactga agcgcttttg acagcgcaat aatgttttcc ttgtccgcat cactatggag 2646061 ctctccgcag acgatcattc ctttttcagc ctctgcgagc atctcagcca catcagacag 2646121 ggactctcgg tcaacagact gcgtacccgt tttcacagac acatgacggc ctgttctcat 2646181 tcttccaaac ggctcatctg aaagatccgg catcagcggt tcgcgcagcg gcacattcac 2646241 atggacaggc cccatcgggc gcttttgtgc ttctccggca gcgcggcttg ccagcgttcg 2646301 gatgtatctc agcatttgcg gagactcttc aggaagagca gagtctgtga aaaacttaac 2646361 aaagttaccg aataagaagt gctgattaat agcctgcggt gcgcctactt cgcgcagctc 2646421 atgaggccga tcagcagtta acacaataat aggcaccctt gaataatggg cttcaaccac 2646481 agccggataa aagttggccg cggctgttcc agatgtacag atcaatagta cgggacgctg 2646541 cttcgctttt gccaaaccta atgcaaaaaa tccggcagac ctttcatcaa tttggacatg 2646601 gacgctgata tcgggatgcg cagcacaaag aacagccagc ggtgtagatc ttgagcccgg 2646661 acaaacgacg gcgtccgtaa ttccggaaag ggcgaattca tcaataaaac ttccgatgta 2646721 atgagtaatc gggttgactg tcaacgcctc tcacctccta atgcagagat catcggcttc 2646781 aatttaatct gtgtttcttc atattccgag attggttccg agtcttccac aataccgcac 2646841 ccggcaaaca gccttgctgt gcttccttcg atgagccctg aacgaatggc gaccgcgaat 2646901 tccccgttat cctggctgtc aatccagccg ataggggccg cataccagcc gcgggacatc 2646961 ggttcaatct ccctgatcac gtcaacagct ttttcctgag gtgatccccc aagcgcggga 2647021 gtggggtgca gcttctcaat taagtcaaaa atcgaagcag actcgcgcag ctgtccgaca 2647081 atcggcgtaa acaggtgctg aacgcttttt gttttgtaca aaacaggtcc atcaggcttt 2647141 tcaacctctg aacagcttga tacaaaagca ttatgaatca tacctaccac aatatcatgc 2647201 tcaagcaggt ttttctcatc gtttaataat tcaaggccta tccggcggtc gtcttcttca 2647261 ttcacgcctc gtttaatgga gcctgccaga caggaagaca tgacagtgcc gccgtctctt 2647321 ttgatcagtc tttccggaga cgcgccgaca aaggttttgc cttcttgttc aattgcaaaa 2647381 acatagcttg tctgctgatc gtccagaagc gttttaagca ccggttcaat ttggattgga 2647441 ccgtcaaacg tgagcagcag ctctcgggca agaacaacct tatcatattg tttctcttta 2647501 atttggcttg tggccgtttc gattgctttc agccaatcat ccttatccag ctcttcggct 2647561 gctgcaatca cagcctgatc ttcttgcttg aaatcgggaa ccataaattc cgccgcaaaa 2647621 gcttttaagc cttctaaaac agcttctgcg tcttctcctc cgcttaccca tctgttaact 2647681 gttaagaacg ggccttcagc agtcatcgtc agcataagcg caggcacaaa gaaatcccct 2647741 tccgagaaat ggtcccattg tgaacctctt tcttcgcaag ggtcaaaaga aaatcctccg 2647801 aataacacag gtcccactgc agaatgctgc agcttttctt cttcataaat atgaaaagcc 2647861 gtctttttaa agcgctccca ttgttcaaaa acctcacgat accgctcgct gtttttttga 2647921 tttgtctgga aaaccgcttc tttgccaaga ccgactattg tcaattcact ttcaggatct 2647981 gaccaaaaaa atcgattgcc tgtatatttt tttgctccgt aattgaaaaa tgatagaggg 2648041 tcaagagact cgatttgtct cgaatagctt attaagacag catggttgac ttctttggct 2648101 ttatgtaatg catgtagaac ttcctttcgg aacgtacgct gcaccgttgt caccatgaga 2648161 cattcctcca taatccttaa aatgctttta ataccataca cctgtgtctc ctttgtgtca 2648221 aacacagatc atgcagtcca aatggcctgc cttacctatt ataaacctaa tttcagaaat 2648281 gaaaaagaaa caaagcttaa atttctttct ccactgatag caaaggttgt atccgcttac 2648341 cataaaagga aaacctccta tattcctcca cccgccattt atgaaagttc tcaggcgatc 2648401 tgttcatact aaaggtatgc atcacagaga aacgaggcga tcacattgct tacgaaagaa 2648461 cagcttcagc atttaaaaaa tgaactggaa caaacgaaaa aagatatctt aaaccgtttc 2648521 aaagacaatg atcattttca gcttaactca gcctttcctt atgattcgtg gggtgagctt 2648581 tcggcatacg acaaccatcc cggcgatcag gcgacagaac tttacgagcg tgagaaagac 2648641 atcgctctag acttgcatga gagagagcac cttcgggaca ttgagcattc attgaaggcg 2648701 atagaaaacg gtacgtatgg catttgtgaa gtcagcggaa aggaaatccc tttcgaacga 2648761 cttgaagcgc ttccgactgc cacaaccctc gcggagtatt cgtcacagga cgtggtttcc 2648821 aaagaccgtc cgattgaaga agaaacacca ttcgggcaat ttgaatttga tgatgatgaa 2648881 gaaatcagag cgccatatga cagtgaggat tcctatcagg atgtcgaaaa atatgggaac 2648941 tcacaaacgc cgcaggatat ggaaaaccct ccgctcagct atgatgatat gacgatgaat 2649001 gccgaagaga atatcggcaa tacggagtct tacgaaaatt tcatcgctac agatatcact 2649061 gggaaagaaa ttaccgttta tcaaagcaga gcccatgagc gctatgaaga agaacttgac 2649121 gaagagggaa tcatgaccac attcggcgat ctccacgctg attgaacccc caattattgg 2649181 gggttctttt ccgttttcag catatcgtaa atcagcttca gataatcctt ttgcaggccg 2649241 atgtcatacc gctcgccctc tagcaatttc ccgtatacgg tacatgcccc gagcgaagct 2649301 tttatcgcat ccgttacctg cacttctcct ccgctatcag cttctaatgc ctccagctca 2649361 ttaaaaatat ccggtgtgaa aatataacgc cctgctgcgg caaaatgaga cggagggttt 2649421 tgtttaggct tttccacaat atcctgtatg cgataaagcc ctttttcaac aggctcccct 2649481 tttatcaccc cgtaatgatg taaatcctcc gtttttgttt cttttaagcc gatcacactg 2649541 gactgatatt tcgtatacgc ttcaatcagc tgccccaaag ccggctgatt ggcggaaaaa 2649601 atcagatcat ctggcaaaac gacggcaaaa ggctctcctc ctgcaaattg ctttccgaaa 2649661 gaaatggcgt cgccaagacc ctttgcataa ggctgccgca catagtgaat ccgtatatcc 2649721 ggaatgggat gctctctaag taaatgcagt ttattcttag aggccaaaaa agcctcaagt 2649781 gccaaagagg aatcaaaata gtcgacaatc agatttttat ggctcgatac aaccatcaaa 2649841 atgtcctcaa tgcctgactc ctttaattct tcaacaagat aatgaatcac aggcttagat 2649901 cctaccggaa acatttcttt cggaatcacc ttcgtcaccg gcagatttct cgtgccgaat 2649961 ccgcctgcag gaatgatcgc tttttttatc atggtatttt cccctcagct catgtttatt 2650021 acatgatatt ccaagagcgc atcccgatgt ttgtacatct gaaattaggc ggaagcaact 2650081 gggcagaaag cggaatcacg aaccagccct tttttaatag gatattgata tatgaccagt 2650141 aatcttgtaa aggagctcag gtgatgaaaa tttgtgtggt tggcgccggg tatgtcggtt 2650201 taaccctatc agcggcactg gcatccatcg gacatgacat gatatgcaca gacaaagacg 2650261 tcaaaaaaat cgggcagctg aaaaaaggag tcattccctt ttacgagcct gggctttcag 2650321 atgcaatact tcgttgcggc aatctctcgt tttcttctga agtgaaatcg agcatggagg 2650381 aatgtcccgt tatttttatc gcagtcggaa ctccgccgcg ttcggacgga tcagctgata 2650441 cgaaagccct gcagtccgtc atcggtgatt taagcgaggc gatccgatcg tataaaacca 2650501 ttattacgaa aagcactgtt ccgcccggga caaatgaaaa catagcaaaa cagctgattg 2650561 cctccggagt gtctaaaaac ctctttaata tcgtatccaa tccggagttt ctgcgggaag 2650621 gcaatgcctt atatgacatg ctgcatcctg acaaaacagt catcggtgtt caggaagaag 2650681 atcacgtatc ggcagccatc gtcaaatcca tttacaaaca cattgatacc ccttttatcg 2650741 ttacaagctt agcgggagca gagctgatca aatatgccaa caatttcttt ttagcggcca 2650801 aaatttcgtt cattaacgaa atggcccgca tatgtgaagc ctatcaatca gatatctcag 2650861 atatttcccg cgctatcggt ctagacccaa ggatcgggaa gcactttttg caggcaggca 2650921 tcggatacgg aggctcttgt tttccaaagg atctgcaggc gctgcaattt gctgcccagg 2650981 aaaaaaacac ggagaccttc ctgctccggg ccgtgcagca cattaatgac acccagcttg 2651041 gcctgtatat caaaaaaata cagtcattct tcgaaacact tcaaggcaag aaagcggctg 2651101 tactcggcat ttccttcaaa ccgaatactg atgacatccg gaattctcag gctgtcagac 2651161 tgatggaaag gctggcggag ctgggatgtg atgttcatgc atatgatcct gaagctgtac 2651221 ttccagaaca tttgcggcaa catgtaactc agcattctca agcttttgat gcgatcgaag 2651281 agagtgactt tttatttttg gcgacagaat ggtctgagtt tttagcgttt gattggaaaa 2651341 aggctgcaga tatcatgaaa gggcgtcttg tgattgacgg acgcaacgta ctaaaaaaag 2651401 aactgatcga ggcttgcggc ctgatctgta cgggagttgg ccgtccatga aaatactcgt 2651461 cacaggagca gcgggcttta tcggctccca cctctgcgaa gaattactaa aagataagaa 2651521 acataacgtt atcggaatcg atgactttat cggtcctact ccattttcct tgaaattaaa 2651581 aaaccttaaa aacctgctgc cggaaaagcg atttacgttc ataaaggaaa atctgctgac 2651641 agccgatctt gcttccttac tggaaggagt ggacgtcatc tttcatttgg cggccatacc 2651701 gggtgtccgc tcaagctggg gcaatcattt tcacccatat gccgcacata atatccaagc 2651761 gctccaaagg ctcctcgagg cgtgccggga acattctatt caaacgttcg tctttgcatc 2651821 cacctcttcc gtctatggcg aaaaacaagg aaaagtcagc gaaaacacgt cgctttctcc 2651881 tttatctccg tacggggtaa caaagcttac gggagaaaag ctttgccatg tgtataaaca 2651941 gagctttggc attccaattg tgattctccg tttttttacc gtatacgggc caagacagcg 2652001 gccggatatg gcttttcacc ggctcattaa gcagcacctt cagcaaaagc cgcttaccat 2652061 cttcggtgat gggcagcagt caagagattt cacttatatc agcgactgtg tcaaaggcat 2652121 caccgctgtt cttgggaaac cccaccttat tggtgaaaca gtaaatatcg gcggcgcaga 2652181 gcgtgcctca gtcttaaaag ttgtctccct cattgaggat atttccggga gaaaagcaac 2652241 actgcacttt tcggacaaaa tagcagggga accgagcaac acgtgggcgg atatttcaaa 2652301 agcaaaacag ctcttgcatt atgatcccgc cacatcctta aaggatggct tgaccaacga 2652361 aatcgcctat ttatcgtcgc tgtatcaggg ggaataaaaa tgaagcttgc ctttatctgt 2652421 acagaaaagc tgccggcgcc cgcagtacgc ggcggcgcta ttcaaatgat gattgacggt 2652481 gtcacgccct atttcagcag caggtacgac ctgaccattt tttcaataga agatccatcg 2652541 ctcccaaaaa gagaaacaaa agacggcgta cattatatcc atctgccaaa agaacattac 2652601 cgcgaggcgg tagccgaaga gctgcgagcc tcttcctttg acctcattca tgtgttcaac 2652661 aggcctttaa atgtctcttt atataaaaaa gcctcaccaa acagcaagat cgttctgagc 2652721 ctgcataacg aaatgttttc tgaaaaaaag atgaccttcg cgcaaggaaa agaagtactc 2652781 gacaatgtct ccatgatcac aacagtgagc gaatttatta aacaaaccgt cattgaacgt 2652841 ttccctgaag ccgaggacat cacaaaagtt gtgtattccg gcgttgattt aaactcttat 2652901 ccgcccgtct ggacgatgaa aggctcggct gtcagaaaaa cataccggaa aaaatacggt 2652961 attgaagata aaaaagttat tttattcgcc ggccgcttaa gcccgacaaa agggcctcac 2653021 cttctcattc acagcatgag acggattttg cagcagcacc ctgatgctgt actggtcata 2653081 gcaggcggga agtggttcag cgatgacagc gaaaaccaat atgtcaccta tctgcgcacg 2653141 ctggcgctgc catacagaga ccacataatc tttacaaaat tcattcccgc agacgatatc 2653201 ccaaaccttt ttctgatggc agatgtattt gtgtgcagct ctcagtggaa cgaacccctc 2653261 gcccgtgtga attatgaagc aatggcggcc ggcacgccct taattaccac aaaccggggc 2653321 ggaaacggtg aagtcgtaaa acacgaagtc accggccttg tcatcgatag ctacaacaaa 2653381 ccttcttcat ttgcaaaagc aattgacaga gcctttacag atcaagaatt aatgaacaaa 2653441 atgacaaaaa acgcccgaaa gcatgtagaa gctttattta cctttaccca tgctgccaaa 2653501 aggctcaata ctgtttacca atccgttctg accccgaaaa acaaacaatt tccgccgcct 2653561 tttctgacgc aaaattttga tttatcatct atcaatcagc tttttgtgaa agcaaaaaca 2653621 taaaacctac agctcgtgtt gcaaaacggg ctgttttttc gctacagaga acttaaaaaa 2653681 aggcataaat gtgactttat gccttgcgct ttacagtttg agaaaaccat ggagctggtt 2653741 tagattcact tggaagaatg atgatttcca ctttagcttc ttccgctaag tctggttctt 2653801 catcttcatc ctcttcttca tatgggggcg ctgagcgttt cgaatcacgc tcctcctcag 2653861 gctccagagt ggtttcgaat tttgtttctt cttcatcatc gacgattttg cgatctgttt 2653921 ccttttcctt cgtttctttt tgatattctt tcggtgcatt gatgtgaggg agctctcgaa 2653981 tgctgcccac atctaaatgc ttctcctctt cttccttctc agctgagatt gagtcatgag 2654041 cctgccatcc catcggtcca ggcggtgtaa atacgaattg gtcgagatcc agtttagaaa 2654101 tagaggcttt ttgtctcgat gacctcatgt caattcgcct cccgatacgc ttttatcttt 2654161 ttatacagtt ccggcagttt atccaaaaac gaatctttag attcttcaac agaaatcatg 2654221 ttttgcagcg cccagttata cttctcatct gaccacgttt tcttttgctt caaataatat 2654281 ttgtgcccga ttgcacagaa caaatgcgga aacgcgagat caatccaaag tacctcgtac 2654341 tgtttttctg tgagcggata cactgcgtcg taggccgcaa gcagtgcaac catgaaatca 2654401 gtatcccata cagaaagctt aaccatcact ttattcagca gaatacgaag gtctcttgac 2654461 ggcaaatcgt aggtaatcga gtgaagctcc tttaaaaaag gctccccttc gatctcagtc 2654521 aaacgtgcca atgtaaaatc ctgaaaacag aatccgccat gctcgagtgt ctcttttgtc 2654581 caggtttcgt attctgagtc atcaagcgct ctgagagctt cttttcctct tgccagcatt 2654641 ttatcagcat gttttaagaa agtttgcgaa aatacgtcat caggatagga tgctgcgatc 2654701 tgcatattcc cttcaagttc ctgcagcttc caacggtaca atttgtgcca ttttcccagc 2654761 ctgcttctct tcttgctttc atctgtgcaa acatatcctt ttgaggcatg atgaaaatgg 2654821 ccggcaaatg acatgacttt tttcatttgc tctgcatcat agtaaatcat ttcttttcct 2654881 gtcactttgt catataaact gtaagaaacc tgatccgtgc ccaagcagct accgccattt 2654941 tttgtttgat gaatcggcgc tatcggcagc cctttctctt gtaaatgggc gtgtgcctga 2655001 gtgataaaaa gcatccgctc cggtttcatt tgcgcttctt ttagcagctt tgggccatga 2655061 tcagtttcga cttcccagat tttgcgcccg cttttgttcg atttcagcgc cacatggtcg 2655121 atatgaaacg gataataact gagaatttcg gacacaatct gttcttcatg ctctttttgg 2655181 tacactctgt tcaccccttc tatctgttct tttcatagac gctgagcaga ttttcagcca 2655241 ccctctgcca gccaaaattg ctttctgcct cacggcggct gtatttccca agccgttccc 2655301 gcttttccga gctgctcagc aaatcattga tacgttcggc atattgttta ggattttcaa 2655361 agtcatgaat gatgtagccg tttttccctt cctctatgac ctctggattg cctccccgat 2655421 tgcttgtaat aataggaagt cccgcagcca tcgcttcata atgcaccctt gctaaaggct 2655481 cctgccattg cgaagagcat acaaatacat ctgacatggt ataaaggcgc ggaatgtcct 2655541 ttggcttcac aaattgaata aatgtgacat gatccttttg catcgcacca agggtatgaa 2655601 gatgtttgac atagttattt aattcattat ctccgaacca ttttgacccg ataaacacca 2655661 tcatgacatc ggggtgctcc tcaatgatgt ccggcaaagc ctgcaataat atgtgcgggc 2655721 ctttgacttt gctaagccgg ccgacaaaca agacgatttt tttgccgtga agccccagct 2655781 cgcttcgcat ctcttcgcga gctcgctgcc cttcattcgt ccagcgaggg tggtacgttt 2655841 ttaaatccac accagaatac accgtttttg tttttgatcg tgctgacgga aaacggcttg 2655901 tgatcgtctg tccgatataa tcgctgaccg taacaatctg cgctacggag tcgatgcaaa 2655961 tctcgccttc cgcctggctg attttatcgt aagcgaacat ttcattgtga acgcttaaaa 2656021 taaaaacagc atccggcgcc tgtttcttca atttcggaac ccagcttggg cgattacaaa 2656081 catgcacaag atcaaaacgg ctctttttca gctctgctcc aacggcttct tcataacggt 2656141 cttcatccaa atgcacataa tggacaccgt ctaccttctc tctatcagcg agattcggat 2656201 ctttaataga aaacacagtc acctcatgtt tttttgcaat taaaggggca accgcttcga 2656261 ggtagatttg aatggcgcct cctcgaaccg atgggacagg aagcttctct gtggcgatca 2656321 gtgctatttt catacatagc ctccattcct gcatgatttt taactagtta gaatcatgat 2656381 acggctgaac aaccaacttg tgcggaatgg gactgcccta aaaacaaaac gggtaaacaa 2656441 ccagattcat ctattaaata tagtcaaata actcaatcat tttttccttt tgattcataa 2656501 ggtaggagta aaacaggtaa ggatgtgtcc tttaatggca gaaaaccatg aagtcattga 2656561 ggaggggaat tcatcagagc ttcctttatc agcagaagat gcaaaaaaat taacggagct 2656621 ggctgaaaat gtgcttcaag gatgggatgt gcaggctgaa aaaatagacg tcattcaggg 2656681 aaaccagatg gcgcttgtct ggaaggtcca cacagactcc ggcgcggttt gtctaaaacg 2656741 aatacacagg ccagaaaaga aagcgttgtt ttccattttc gcgcaggact atttagcaaa 2656801 aaaaggcatg aatgttcctg gcatactccc aaacaaaaaa ggcagcctat attctaagca 2656861 cggctcattt ctatttgtcg tatatgactg gatcgaagga agaccgtttg agctgactgt 2656921 aaagcaggac ttggagttta tcatgaaagg ccttgctgat tttcatacag cttccgtcgg 2656981 atatcagccg ccaaatggcg ttcccatatt taccaaatta ggtcgctggc cgaatcacta 2657041 cacgaaacga tgcaaacaga tggaaacgtg gaagctgatg gcggaggcgg aaaaagaaga 2657101 tcctttctca cagctttatc ttcaggagat agatggcttt attgaagacg ggctgcgcat 2657161 caaagaccgg cttttgcaat cgacctatgt tccatggact gaacagctga aaaaaagccc 2657221 taacctttgc caccaggatt acggaaccgg gaatacactc ttaggagaaa atgaacagat 2657281 ttgggtcatc gacttagata ccgtatcatt tgatctgcct attcgcgatt tgcgcaaaat 2657341 gattattccg cttttggata cgacgggtgt ttgggatgac gaaacattta atgtcatgct 2657401 gaacgcatac gaatccagag ccccattaac tgaagaacaa aaacaagtca tgtttattga 2657461 tatgctgttt ccttacgagc tttacgatgt cattcgcgaa aaatacgtcc gcaagtctgc 2657521 tttaccgaag gaagaattag aatcagcttt tgaatatgaa cgcattaaag caaacgcatt 2657581 gcggcagctt atttaagacc atcatttccc ccgcatatcg ggggtttgat atttataaga 2657641 taaagggtaa ttaaatacat gcggaggttg caaatatgaa aaagattgtc ggcgctttag 2657701 ccgtttttgt gattacatat gcgctgtttt cagccgcagg ctacctgttt cctgtggacc 2657761 aagaatggta caattcattg aaaaaaccgg actggacgcc aagcggaact gcgatcggca 2657821 tcatttgggc catcctgttt gccctgatct ccctttcagc agccattgta tatgctgcgt 2657881 tttcatttaa aggtgcgaaa agcttttggt ttacactttt gataaattac gtgctcaatc 2657941 aagccttcag ctatttccag tttacgcaaa aaaatctgct ggctgcatcg cttgactgcc 2658001 tgcttgtcgc catcacagca atcgtattac tgatcattgc caaaaaatac agcagagccg 2658061 caagctatct tcttttgcct tattttttat ggagtgcatt tgcgacgttc ttatccttta 2658121 caatcaattc aatgaatctg tgaacaaaaa aagccgctta tacagcggct ttttcacatc 2658181 atcggcttga tgccccaaat gtccttcgca tattcccgga tcgtgcggtc gctggagaaa 2658241 tatccagaat gagcaatgtt tacaatcgaa tgctcagacc atttccttcg ctctcgataa 2658301 tcagcttgaa ttcgctcctg tgcatctgca tatgagctga aatccttcag cacaaaatac 2658361 tcatcattat gcggaagcag cgagtcaaag atcgattcaa attcatctgc ctctccttca 2658421 aaaaaaccat tgatcaactg atccgctacc tgcctgattc tcctgtcatg ctgataatat 2658481 tccctcgacc tatagccgcc gttttcctga tacgatagaa cctcatccgc ctttaagccg 2658541 aacgtgtaaa tacagtcagg gcccacccgc tcaaggatct cgatatttgc gccgtcatgc 2658601 gtgccgatcg tcaaagcccc gttcatcata aacttcatat tccctgtacc agacgcttcc 2658661 ttgcttgcgg ttgaaatttg ctcacttacg tctgatgccg gaaaaattcg ctcagccata 2658721 gaaactctat aattttctaa aaaaacaact ttgatcagct gtttgaccgc cggatcataa 2658781 ttgacttttt ctgcgacaga atggatcagc ttaatgattt tcttggcata ataatagctt 2658841 ggtgaagcct ttgccccgaa aataaaggtt tgcgggtaga ttgaaaaccc cgaatcctcc 2658901 ttgaggcggt tatacaaata cataatgtga agaacattca gcagctgccg tttatatgca 2658961 tgaagccgtt tcacctgtac gtcgaatatg ctctcagggt tcacaaccac cccggccgtg 2659021 caaaaaatca aatcggcaag ctcttgtttt ttcttgcttt tgttgttttg aaactgttca 2659081 ataaatgcag gatcagtggc gtacggttct aaacggatca gtgattccgg ctgcttgacc 2659141 cattcatcgc cgatcgcctc tgtaatgatg gcagacaagc ctggattcgc ttttaacagc 2659201 cagcgcctgt gggcaattcc attcgtctta ttgttaaaac gattcggaaa cagcaagtga 2659261 aagtcgcgca tctccctttc ctttaatata tcggaatgta tttttgcaac gccatttaca 2659321 ctgtagctgc ctactatggc cagatgagcc attttgacaa caccatgcgc tgtaatcgcc 2659381 atgttctcta tccttttcca gtctccagga tacttttccc aaactgcacg gcaaaacctc 2659441 tcattgatct cttcaataat catgtacatt cgcgggagca gcggcttaaa caaatgaatc 2659501 ggccatttct cgagcgcttc tgacaatgtt gtatgatttg tataagaaat cgtatgtaca 2659561 gtgatatgcc aagcttcttc ccagctcatg ttctcttcat cgagcaaaat ccgcattagc 2659621 tcaggcaccg caagcgcagg gtgagtgtca ttaatatgaa tgctcacttt tttatgcagg 2659681 ccggataaag atttatgtgt tttacggtaa ttgttcacaa tgctttttaa gcttgcgcat 2659741 actaaaaaat actgctgctt cagccgtaaa attttcccct catcatgggt gtcatcggga 2659801 tataagaatt cagaaaccgc ttctgtttct cgcttataag acaaaatatt accgccgtga 2659861 taatgggcat agggctcggc gttccaaagc cttaacgtgt tgacagtgcc cgtttcatag 2659921 ccgatgatcg ggatatcata aggaacagcg gtaacaattg tcgcttgttc atggcgaaaa 2659981 tgcaggcgcc cgcttttttc tgtcatatgg acttcgcccc aaaacggcac gtccactgct 2660041 tgatccgcat tccttacttc ccatacgttc ccgtttttca gccattgctc aggcagctcc 2660101 acctgatgtc cgtctacaat tttttgctca aacaaaccat gcttataacg tatgcccatg 2660161 ccgtgcccag gcaggttcaa cgaagcaagc gaatctaaaa agcaagcggc caagcgccca 2660221 agtccgccat tgccgagacc tgcatcgttc tctatctgaa ggatctcctc taaattgatg 2660281 ccgatttcct ttaaaccagc ttctacaaca tcacgaacac caagattcat taagttttgc 2660341 tcaaggagct gaccgagcag aaattcgatt gataaataat atgtctgctt cccggaattt 2660401 gatctgcttt tttcattcgt ttcgatccaa tcagcgctga tatactctct gaccatattg 2660461 cccaacgttt tatattgatc cagcttggca gaatctttaa agctttttcc gcacgtcatt 2660521 tccagacgct ttaaaaataa gtctgcaaag cgttctttac tcgagaacat cccgtccact 2660581 ccttgtcacc tgctcgaaaa tacgctgata ctctttagcc gacttccccc agctgtaatc 2660641 tgcattcata gcggtcttca cgatgctctt ccatacatcc tgttggcaat aaaacgacag 2660701 cgccctttct atcgtaaatt tcagatcatg cgcattaaag gcggaaaacg taaagccatt 2660761 gcccgttccc tcttcctcct gataggcacg gacagtgtcg taaagaccgc ccgtttccct 2660821 gacaatcgga atggcgccat attgaagagc aatgagctgc cccaaaccgc acggctcaaa 2660881 tttcgacggc atcaaaaaca tatcagagcc cgcataaatt tgatgggcta gcggctcatc 2660941 aaacccgata taagcccggc acttctcatg aaaagcaaat tctgcatacc ggaaataatc 2661001 ttcaaattca cgttctcctg tgcctagcac aaccagctgt atgtcttgct cctcaagaag 2661061 ttcgtgcata attctgcgga caagatcaag ccccttttgt ttagtgagcc ttgtcaccat 2661121 actgatcagc ggaatatcgt ttttctctgg aagccccatc cgctgctgaa gcttcgtttt 2661181 gttttccagc ttgcatgcaa gatcccctga atcgtattgc gcctctatat aagggtcgct 2661241 tttcggctga tagaacgtat catcaatgcc atttaatatg ccggttacat catcttccct 2661301 atattgcaaa acctgttcca actgctcacc ataatacggc gtcatgattt catttctgta 2661361 agtggggctc acagttgtca catgatcagc cgcaatgatg cccgctttca taaaattaac 2661421 aaatccgttg cattctaacc tttcataatg aaaatgatcc atctcaagac ccagcaagtc 2661481 atgtgtgaca tcaggaggga atatgccttg aaactgcagg ttgtggatcg tgagcacgct 2661541 tttcatccgt tcataaaaag gatgttttct gtactcctct ttcagcaaat aattgaccat 2661601 cgctgtatgc caatcgtgag tatgaacaat atcggcttga acattcacaa ctttggcagc 2661661 ctccagcaca gctcttgaaa aaaaggcaaa ccgctcaccg tcatcataat gcccgtacaa 2661721 cgaatccctg ttgaaatagt actcattgtc gatgaagtaa taattcacat cattctctgc 2661781 catatgttca attccgcaat attgctgccg ccagccgaca gctacggtac actcagcctg 2661841 ttttttcata cgctttttcc acggttcagg tatttggctg tacttcggca gcatcacagc 2661901 tacctcattg cctaatcgcg caagcgcctt tggcagagca cctgctacat cggcaagacc 2661961 tcctgatttc acaaatgggg tgcattctga cacagcaaat aatatcttca agaattcatc 2662021 agctctcctt gcaccaaacc ttttcttaat acaagcggct gctcagctgt tcctgcagct 2662081 tccgtcgcct tgccgatttt aacatcctta tccgaaatga cctgctcaag aagacaatcc 2662141 tctccaatct gcgttttttg cataataatg cagtttttca gcttcgtacc ctttccgaca 2662201 tggaccgccc tgaacaaaat gcagttttca acctctcctt caagcacaca gccgtttgcc 2662261 accaaagaat ttttgacagt gctgtgcttt ccgtatttcg taggcggctc atccttcact 2662321 tttgtataga tcggctgctg cggcaaaaac acctgctgcc aaaaacgagg ctgaatgagc 2662381 tccatactgt gggtataata tttttccacc gaatcaatga cagcggcata acctgaatat 2662441 tcataagggc aaatggtcag ggcggaagat tccttttcaa cagcctcctg aatggtttta 2662501 tagccttttt cgctatgtcc gtagatcaga tcctttaaaa gcgttgttga catgatatag 2662561 atttgcagcg actggccgtc ctgaaatacc tcggtgacgt cgcagccaac ctcctgatgg 2662621 cgtttcagca catattgaaa ttgaatgttg catacggtat ggctgttgga gattacagca 2662681 tattgctgag tgcttctgtg gaagtaatct agatggtccg aaaactggcg aaaggaaccg 2662741 aattcatcgt attcgtgatg aagatgggga gacgggaaaa aaaagaggcc gtcctttttc 2662801 cggtgcaaat cccattcctt acccgcccca aggtgatcca tgagcgaacg gtaacgatac 2662861 ttcggaaaaa ttgcaacact cctaatatcc gcattcacca tgttggaaag cataaaatca 2662921 atcagtcggt acctgccggc aaaagggatc gccccgagcg accgctgtgc tgttaaatcc 2662981 tgaagagaat gcttatatgt ggtttcatct ataacaccta acatttgatt attgaacact 2663041 gactctgccc cctcttcagt aattaaatca attctttttc tacaaattcc tctgaaacga 2663101 gcagcacctc ttcaatgtct ttttcggagc gaatcactgc gccatccggc agcaccatcc 2663161 cattaggaac gatggcattt tcaatgacta catgctcccc aatcgtcaca tccggcatta 2663221 tgacggatga tgtaacagtc gtatgcttac caacagtcac accttgaaaa agaacggagt 2663281 gagacacatt tccatataca acacaacctt cgttcacaag cgaatcttga acctgcgcat 2663341 cagatgaaat aaattgcgga ggctgatttg gattgacgga gtaaattttc catttgcgtt 2663401 caaacagctt cagctccgag tcctctttta acaaatccat attggcttcc cacaagctct 2663461 gcaccgttcc gacatccttc caatatccct tgaacggata agcagaaagc ttctttttct 2663521 cttccaaaag cagtggaata atgtctttgc cgaagtcgtg gctagaataa gggttttgat 2663581 cgtccatctc aagatactgt ttcaaaagcg gccaattgaa tatataaatt cccattgagg 2663641 caagattgct cttagggaat ttgggctttt catcaaaatg tgtgatcgtc ccatctggat 2663701 tggccttcat gatgccgaac cggcttgctt cctcccagcc cacttcgatg acagagatgg 2663761 tcacatctgc tttcttttca atgtgataat caagcatttt gccgtagtcc attttgtata 2663821 tgtgatctcc tgataaaatc agtacatact caggatcata ctgattcaaa taattgagat 2663881 tttcataaat ggagcttgcc gtccctttat accatttgac ttctgatgac tcggcataag 2663941 ggggtaaaac cgtcacgccg ccattatatc tatccaggtc ccatgcactg ccgatcccaa 2664001 tataggaatt cagctcgagc ggctgatatt gcgttaaaat cccgactgtg tctatgcctg 2664061 aattagaaca gttgcttagg gtaaaatcaa taatcctgta ttttcccccg aaagatacag 2664121 ccggtttggc catatttttt gttaatccgc tgagacggct gcccttcccg ccggcaagga 2664181 gcatggctac acattgtttt ttcatctttt tatctctcct ctttttttaa ccgcccgtaa 2664241 aatcgagatg ccgtaagggg ggatggtcat cgtgatataa cacggtttat gatgaagtgc 2664301 tcccttttta gccgataacg gctttttgtt gatttgccct gagcctccat atgtttcact 2664361 gtcactgtta agcacttcaa tgtattgagt aaaaaaagga actccaacat catattgatg 2664421 atagaccacg ggtgtaaaat tacaaatgat gacaagcgcc tcaccgtgct tttggccata 2664481 acgaataaaa gaaaagattg attgttcgtc attatggaca tcaatccatt caaacgattg 2664541 tgcacgatgg tcatgctcat aaaggatttt gcttttttgg taaaagcgga gaagatcttg 2664601 cgtaaaaacg ctggctttct gatgcatggg gaaggagtcc aaaaaccaat caagctgttc 2664661 tgtatctttc cattcatcaa attgagcaaa ctctgatccc ataaagatca atttctttcc 2664721 gggatgcact gtcatatagc ccagcaaaag ccgatactgg gcaaatttct gccagtagtc 2664781 gccaggcatt ttattgagaa gtgatttttt tccgtatacg acttcatcat gagaaaacgg 2664841 caatacaaaa tgttcactaa acgcatatag taatgaaaaa gagataagct gatgacaatg 2664901 ccgcctttct tcgggcggcg tctccatgta tttcagtacg tcattcatcc atcccatatt 2664961 ccatttataa tgaaaaccaa gccccccttc ctcaacggca cctgtcactt gaggccattc 2665021 tgtagaatct tctgcaatca tcatcacatg gggatatgcc tctctcatgg tttgattgag 2665081 tttttttaaa aaatcaacag catatggatt cgtgtggcgt tcatcctgat ttggccaata 2665141 caagatatta gccactgcat caaccctaaa tccatctata tgatagaatt ccgcccagta 2665201 caacgcattc gaaattaaaa aactatgaac ttccggtttc cccaggtcaa agtttgccgt 2665261 gccccataac cagttctccc gatcacgttc ttctttgtat tcataaagcg gttctccatc 2665321 aaacatataa aggccatgtg catctttaca aaaatgtccg gggacccaat ccaaaatgac 2665381 tccgatattt tgttgatgac attcatccac aaacttcatc agatcatgcg gcgggccaaa 2665441 cctgcttgtc gggctgtaat accccgttcc ttggtacccc catgaacgat catatggatg 2665501 ctcatacacg ggaagcagtt caatatgggt aaacccatgc ttcttgatat aagggataag 2665561 cgtctgactt aattctttat aggaataatg cctgccatca gaatgcttct tccaagaccc 2665621 aagatgcagt tcataaatga aaacaggttt ttcatacagc gtcttagcct tctgtttctt 2665681 ttgccatttt tgatcttgcc agctgtatcc ttccaaatcg taagtaagtg acgctgtgtt 2665741 tggtctgact tctgaataaa tagcgtatgg atctgccttc agcctgatct caccgttatt 2665801 cgtcacaatt tcgtatttat atcgttcctt ttctcctata cctggaataa ataacgtcca 2665861 aatgccatta tcattcactc tgtgcatcac atgctcttct ccagaccagc tgttaaaatc 2665921 tccagccact cgtacttccg acgcatgagg cgcccacaca cagaattcat atccgctttt 2665981 gccattcagc tcgcggtaat gcgagccaaa cagctgatag cttttaaaca gactgccttc 2666041 gtgaaaaaga taaacatcat gtgctgtcgg gctggcagcg gccatgtaat catcctttct 2666101 gacatcatag ttttcattta tagtatttat tcgaagaaat aaaaaaaagc cctttcctga 2666161 aagcgcttat acttatagac aattaacttc attttctgaa gaaaaacgaa atatatggag 2666221 atttttgtag tctgttttta aaataaagaa caaaatctaa gacatatcat gatttataaa 2666281 aacaaaaaaa ccttgcagga tatgcaaggc ttctggatga cccgtacggg attcgaaccc 2666341 gtgttaccgc cgtgaaaggg cggtgtctta accgcttgac caacgggccg ataattatga 2666401 tatctgtaat catatggcgg agaaggaggg atttgaaccc tcgcgccgct tacacgacct 2666461 acacccttag caggggcgcc tcttcagcca cttgagtact tctccatttg gctccacagg 2666521 caggattcga acctgcgacc gatcggttaa cagccgatag ctctaccact gagctactgt 2666581 ggaacaaaag tcatggtggg cctgaatgga ctcgaaccat cgacctcacg cttatcaggc 2666641 gtgcgctcta accagctgag ctacaggccc atgacgatat agaaatggag cgggtgatgg 2666701 gaatcgaacc cacgacatca gcttggaagg ctgaggtttt accactaaac tacacccgca 2666761 atttttattt ggggcgattg atgggaatcg aacccacgaa tgccagagcc acaatctggt 2666821 gcgttaacca cttcgccaca accgccaaag catattgata aatggtggct cgggacggaa 2666881 tcgaaccgcc gacacacgga ttttcagtcc gttgctctac caactgagct accgagccta 2666941 agtatttaaa tggcggtccg gacgggactc gaacccgcga cctcctgcgt gacaggcagg 2667001 cattctaacc aactgaacta ccggaccatt ttaaaatttg gttgcggggg caggatttga 2667061 acctgcgacc ttcgggttat gagcccgacg agctaccgaa ctgctccacc ccgcgatgat 2667121 taggaatatg tatggcggag gaagagggat tcgaaccccc gcgggctttg acacccctgt 2667181 cggttttcaa gaccgatccc ttcagccaga cttgggtatt cctccgtata gtggtggacc 2667241 ttgtaggact cgaacctacg accggacggt tatgagccgt ctgctctaac caactgagct 2667301 aaaggtccat tggtagcggc ggaggggatc gaacccccga cctcacgggt atgaaccgta 2667361 cgctctagcc agctgagcta caccgccaaa tatttttgaa atcaagtgga gcctagcggg 2667421 atcgaaccgc tgacctcctg cgtgcaaagc aggcgctctc ccagctgagc taaggcccca 2667481 agaatggtcg ggaagacagg attcgaacct gcgaccccat ggtcccaaac catgtgctct 2667541 accaagctga gctacttccc gatttcatat agatcatggc gcgcccgaga ggagtcgaac 2667601 ccctaacctt ttgatccgta gtcaaacgct ctatccaatt gagctacggg cgcaaaactt 2667661 aatgccgagg gccggacttg aaccggcacg gtagtcacct accgcaggat tttaagtcct 2667721 gtgtgtctgc caattccacc accccggcgt ggatggtata gttggagcgg aagacgggat 2667781 tcgaacccgc gacccccacc ttggcaaggt ggtgttctac cactgaacta cttccgcaga 2667841 aatggtgcgg atgaagggac ttgaaccccc acgtctgtaa agacactaga gcctgattct 2667901 agcgcgtctg ccaattccgc cacatccgca acatgtaaat ggtgagccat gaaggactcg 2667961 aaccttcgac cctctgatta aaagtcagat gctctaccaa ctgagctaat ggctcttctt 2668021 acaatagact tgaatattat atcatataaa agtggtgccg gcaagaggac ttgaaccccc 2668081 aacctactga ttacaagtca gttgctctac caattgagct acaccggcat atatgtaaaa 2668141 ccgatatgta taatgaaaaa tggtggagga tgacgggctc gaaccgccga ccctctgctt 2668201 gtaaggcaga tgctctccca gctgagctaa tcctccatac ttgcactaac gtgcaattgc 2668261 ttggcggcgt cctactctca cagggggaaa cccccgacta ccatcggcgc tgaagagctt 2668321 aacttccgtg ttcggtatgg gaacgggtgt gacctcttcg ctatcgccac caaacaaatt 2668381 gagagtgttc tctcaaaact agataacagg tgtgacatca ttcaaaaata tggttaagtc 2668441 ctcgatcgat tagtatctgt cagctccatg tgttgccaca cttccacctc agacctatca 2668501 acctgatcat ctttcaggga tcttacttcc ttgcggaatg ggaaatctca tcttgagggg 2668561 ggcttcatgc ttagatgctt tcagcactta tcccgtccgc acatagctac ccagcgatgc 2668621 ccttggcaga acaactggta caccagcggt gcgtccatcc cggtcctctc gtactaagga 2668681 cagctcctct caaatttcct gcgcccgcga cggataggga ccgaactgtc tcacgacgtt 2668741 ctgaacccag ctcgcgtacc gctttaatgg gcgaacagcc caacccttgg gaccgactac 2668801 agccccagga tgcgatgagc cgacatcgag gtgccaaacc tccccgtcga tgtggactct 2668861 tgggggagat aagcctgtta tccccggggt agcttttatc cgttgagcga tggcccttcc 2668921 atgcggaacc accggatcac taagcccgac tttcgtccct gctcgacttg taggtctcgc 2668981 agtcaagctc ccttgtgcct ttacactctg cgaatgattt ccaaccattc tgagggaacc 2669041 tttgggcgcc tccgttacct tttaggaggc gaccgcccca gtcaaactgc ccacctgaca 2669101 ctgtctcccc gcccgataag ggcggcgggt tagaaggtca atacagccag ggtagtatcc 2669161 caccgatgcc tccaccgaag ctggcgctcc ggtttccaag gctcctacct atcctgtaca 2669221 agctgtacca acattcaata tcaggctgca gtaaagctcc acggggtctt tccgtcctgt 2669281 cgcgggtaac ctgcatcttc acaggtacta taatttcacc gagtctctcg ttgagacagt 2669341 gcccagatcg ttgcgccttt cgtgcgggtc ggaacttacc cgacaaggaa tttcgctacc 2669401 ttaggaccgt tatagttacg gccgccgttt actggggctt caattcgcac cttcgcttac 2669461 gctaagcgct cctcttaacc ttccagcacc gggcaggcgt cagcccctat acttcgcctt 2669521 acggcttcgc agagacctgt gtttttgcta aacagtcgcc tgggcctatt cactgcggct 2669581 ctctcgggct tgcaccctaa cagagcaccc cttctcccga agttacgggg tcattttgcc 2669641 gagttcctta acgagagttc tctcgatcac cttaggattc tctcctcgcc tacctgtgtc 2669701 ggtttgcggt acgggcacct ctcacctcgc tagaggcttt tcttggcagt gtggaatcag 2669761 gaacttcgct actatatttc gctcgccatc acagctcagc cttatgggaa acggatttgc 2669821 ctatttccca gcctaactgc ttggacgcgg atatccaata ccgcgcttac cctatcctcc 2669881 tgcgtccccc cattgctcaa atggtgagga ggtggtacag gaatatcaac ctgttgtcca 2669941 tcgcctacgc ctttcggcct cggcttaggt cccgactaac cctgagcgga cgagccttcc 2670001 tcaggaaacc ttaggcattc ggtggagggg attctcaccc ctctttcgct actcataccg 2670061 gcattctcac ttctaagcgc tccaccagtc cttccggtct ggcttcacag cccttagaac 2670121 gctctcctac cactgttcga agaacagtcc gcagcttcgg tgatacgttt agccccggta 2670181 cattttcggc gcagagtcac tcgaccagtg agctattacg cactctttaa atggtggctg 2670241 cttctaagcc aacatcctgg ttgtctaagc aactccacat ccttttccac ttaacgtata 2670301 ctttgggacc ttagctggcg gtctgggctg tttccctttc gactacggat cttatcactc 2670361 gcagtctgac tcccaaggat aagtcattgg cattcggagt ttgactgaat tcggtaaccc 2670421 ggtaggggcc cctagtccaa tcagtgctct acctccaaga ctcttacctt gaggctagcc 2670481 ctaaagctat ttcggagaga accagctatc tccaggttcg attggcattt cacccctacc 2670541 cacacctcat ccccgcactt ttcaacgtgc gtgggttcgg gcctccattc agtgttacct 2670601 gaacttcacc ctggacatgg gtagatcacc tggtttcggg tctacgacca cgtactcatg 2670661 cgccctattc agactcgctt tcgctgcggc tccgcatctt ctgcttaacc ttgcacggga 2670721 tcgtaactcg ccggttcatt ctacaaaagg cacgccatca cccgttaacg ggctctgact 2670781 acttgtaggc acacggtttc aggatctctt tcactcccct tccggggtgc ttttcacctt 2670841 tccctcacgg tactggttca ctatcggtca ctagggagta tttagccttg ggagatggtc 2670901 ctcccggatt ccgacggaat ttcacgtgtt ccgccgtact caggatccac tcaggagaga 2670961 acgaagtttt gactacaggg ctgttacctc ctatggcggg cctttccaga cctcttcatc 2671021 tacctcgttc ttttgtaact ccgtacagag tgtcctacaa ccccaagagg caagcctctt 2671081 ggtttgggct gatcccgttt cgctcgccgc tactcaggga atcgcatttg ctttctcttc 2671141 ctccgggtac ttagatgttt cagttccccg ggtctgcctt ctcatatcct atgaattcag 2671201 atatggatac cactccatta cgagtggtgg gtttccccat tcggaaatct ccggatcaaa 2671261 gcttgcttac agctccccga agcatatcgg tgttcgtccc gtccttcatc ggctcctagt 2671321 gccaaggcat ccaccgtgcg ccctttctaa cttaaccgtt aaaaagaatc actatgtgat 2671381 atcttgtgtt actaattgaa tgtgatgtct actgttatct agttttcaaa gaacacgttt 2671441 cgaaggaatg atccttcaaa actaaacaag acagggaacg ttctgtttat aagaccttgg 2671501 gtcttatatt ccgtataata tccttagaaa ggaggtgatc cagccgcacc ttccgatacg 2671561 gctaccttgt tacgacttca ccccaatcat ctgtcccacc ttcggcggct ggctcctaaa 2671621 aggttacctc accgacttcg ggtgttacaa actctcgtgg tgtgacgggc ggtgtgtaca 2671681 aggcccggga acgtattcac cgcggcatgc tgatccgcga ttactagcga ttccagcttc 2671741 acgcagtcga gttgcagact gcgatccgaa ctgagaacag atttgtggga ttggcttaac 2671801 ctcgcggttt cgctgccctt tgttctgtcc attgtagcac gtgtgtagcc caggtcataa 2671861 ggggcatgat gatttgacgt catccccacc ttcctccggt ttgtcaccgg cagtcacctt 2671921 agagtgccca actgaatgct ggcaactaag atcaagggtt gcgctcgttg cgggacttaa 2671981 cccaacatct cacgacacga gctgacgaca accatgcacc acctgtcact ctgcccccga 2672041 aggggacgtc ctatctctag gattgtcaga ggatgtcaag acctggtaag gttcttcgcg 2672101 ttgcttcgaa ttaaaccaca tgctccaccg cttgtgcggg cccccgtcaa ttcctttgag 2672161 tttcagtctt gcgaccgtac tccccaggcg gagtgcttaa tgcgttagct gcagcactaa 2672221 ggggcggaaa ccccctaaca cttagcactc atcgtttacg gcgtggacta ccagggtatc 2672281 taatcctgtt cgctccccac gctttcgctc ctcagcgtca gttacagacc agagagtcgc 2672341 cttcgccact ggtgttcctc cacatctcta cgcatttcac cgctacacgt ggaattccac 2672401 tctcctcttc tgcactcaag ttccccagtt tccaatgacc ctccccggtt gagccggggg 2672461 ctttcacatc agacttaaga aaccgcctgc gagcccttta cgcccaataa ttccggaaaa 2672521 cgcttgccac ctacgtatta ccgcggctgc tggcacgtag ttagccgtgg ctttctggtt 2672581 aggtaccgtc aaggtaccgc cctgttcgaa cggtacttgt tcttccctaa caacagagct 2672641 ttacgatccg aaaaccttca tcactcacgc ggcgttgctc cgtcagactt tcgtccattg 2672701 cggaagattc cctactgctg cctcccgtag gagtctgggc cgtgtctcag tcccagtgtg 2672761 gccgatcacc ctctcaggtc ggctacgcat cgttgccttg gtgagccgtt acctcaccaa 2672821 ctagctaatg cgccgcgggt ccatctgtaa gtggtagccg aagccacctt ttatgtttga 2672881 accatgcggt tcaaacaacc atccggtatt agccccggtt tcccggagtt atcccagtct 2672941 tacaggcagg ttacccacgt gttactcacc cgtccgccgc taacatcagg gagcaagctc 2673001 ccacctgtcc gctcgacttg catgtattag gcacgccgcc agcgttcgtc ctgagccagg 2673061 atcaaactct ccgataaatg gatcacaggt taagttcacc gcatcctgcg gcgacacctg 2673121 tgtgacctgc gtcgtgcagg ccctagtttg actgactacg cacatcgcag tgcgattttt 2673181 aaaaactgaa ttaacaggta cgttttgtct tgtttagttt tcaaagatca tttcgttact 2673241 tctcaatgaa gcagctttac taatataaca ttcagcttct tttttgtcaa caactttttt 2673301 caagttgttt tgaagcatct agtttgtgtc cgctgtgcat cagcgacgtt taataatata 2673361 acacctgtat ttatttattg caatagtttt ttaaaaaaaa tctataaaac aaataaacta 2673421 taatcctcgc catgatttct aaagcgtgtg tatcatataa gtttcttaaa agaacatata 2673481 catcagtcat gtgatcttgt tgtttttttc gttttcttgt atagtagaaa cgaactaaat 2673541 actgatgacc acaaggggag cattaaagct gagagtgagc ggtttcgttc tgaccctttg 2673601 aacctgttag ttaacgctgg cgtagggatg tggcaaagtc aaatgaattg cagatcgtaa 2673661 agcagtgcgt ggaacttttc tcatccttcc gcgtgctgct tttttgttgt ccttttggtt 2673721 gtctgtcaat ggaaggagat agatatgaat caatctaagc aactggttcg ccttattgaa 2673781 attgccatta tgacagcggc agccgttatt ttagacattg tctcaggaat gtttcttagc 2673841 atgcctcaag gaggctcggt ctccatcatg atgattccga tctttttaat ttcgtttcgc 2673901 tggggtgtca aagcaggtct tactacaggt ttgttgacag gtctagtaca aatagcaatc 2673961 ggaaacttgt ttgctcaaca tcctgtacag ctattgttag attacattgt cgctttcgca 2674021 gcaatcggca taagcggctg tttcgcttct tctgtccgta aagccgctgt atcaaaaaca 2674081 aaagggaaat tgattgtttc agtggtcagc gcagttttta tcggcagttt gctgcgctat 2674141 gccgcgcatg tcatttcagg agctgtgttt ttcggcagct ttgctccaaa aggaacaccg 2674201 gtatggattt attctttaac ttataatgcg acttacatgg ttccttcatt cattatttgt 2674261 gcaattgtcc tatgtttatt atttatgaca gcaccccgtc tgcttaaaag tgacaaagcg 2674321 taaaagtaac aatcccccag cgaattccgc tgggggattt ttcgttatct gttaagaagt 2674381 gtttttaaag ctgaaagatc cggccagcca agacctactt ctttcagcct tactccggca 2674441 atttcaaagt tgtcctccgc tactctttca ggtgaatagg cctgataaaa tataatcgag 2674501 ggattctgct caataaccca aacaaacata cttgaaaaac catgttgaag caaaaactcc 2674561 gctccttttg ctaagagcgc cctgcctgca ccttgccgct ggcgctcttc cagaagataa 2674621 atagcgtata actcgccgtc atagccttct tgttcagagc gaataggtcc aaatgaagca 2674681 aagccgaata ctgaaccctt ttcgtcctga gcaacaaata ctccctttaa cgagcgactt 2674741 ttccatttgt cttcaaattc cttatagttc aggctgttta aataatcaat cgggataatt 2674801 tcgtggtatg ttgtcctcca gctgtctaca tgcacttttg caatgtcctt tatatcctct 2674861 aacttcgctt cacgtacagt taccatacgg ttctgccctt tccttactct gatttttgga 2674921 tcgttttggc ttctttgatt tcatttgtta attcattaat gctttgtttt acgtttcctt 2674981 ttcctgaaaa gttctcaagc atttctttta catcaattcc tgaggatgct tttaaacttt 2675041 cttgcagact tgacattaag ttcgtcgcat agctggttac tttgtttgct ccgcttgatt 2675101 caccgcttcc tcctgtatcg acaacggtga ttttatcaat atttgaaaga ggtgccgctg 2675161 cttgtttcgc gtattccgga agcattttga caatcatatc gaaaatcgcc gcctgcccgt 2675221 actgttcaaa ggcggccgca attttctctt ttgcttccgc ttctgcaaga cctttcaggc 2675281 ggataacctc tgcttctgtc tctcctttcg ctttttccgc ttctgctttt gctagcccgt 2675341 caattcttac tttttccgcc tcagcctttg ccattgcttc aatactgtac ttcttggcat 2675401 cggcttccgc gagctgtttg gctttctcag ctgctgcgga ctgctcaaca gaataacggt 2675461 ctgcatcggc ttttttcttt acctctgagt cgtattgacg ttcacggcga agaatttctt 2675521 tttcttctag ttctatttgt ttttggcgtt cgataatttt aacctgcatt tcctgctctg 2675581 tgacttgctg gcgcgctcgg gcagtctcta aatcatatgc ttggtcggca ttcgcttttg 2675641 ccgtatcttg ttctctgcgg aattcagcca ttttgagctg attgattttt tcagcttcag 2675701 cgatttccgt cgcccgttca agttctgatt tttttgcgtc tttatcggct tctgcccgct 2675761 taattcgggt ttctttatca gcctctgctg ttgcgatatc agcatcgcgt tttacttggg 2675821 caattctcgg tttccctaat gattcaagat aaccgttttt atcacgaaca tctttaatgg 2675881 taaacgagac gattacaagt cccattttcg cgagatcctg tgaagcgaca cgctgcacct 2675941 cttgagagaa tttttctctg tttttataga tttcttctac tgtcattgag ccgagaatgg 2676001 aacgaaggtg gccttctaaa acctcccgcg cttcctgctc acggtcgtct tttgatttcc 2676061 ctaaaaattg ttcggccgct gtagcgattt ctcctataga accgccgatt ttaataatcg 2676121 cagttccatc ggccattact ggcactcctt gttctgtata gacttcaggt gtcgaaacat 2676181 cgagtttgct tgataatagg cttagcggct ctgcctgctg gaagacggga aggacaaagg 2676241 ttcctccgcc gcggacgatt ttaatacggt tgccgccttc atcgacatga acatttttat 2676301 tacccagata gctccctgtt acaattaacg cttcatcagg ccctgctgta cgatacttcg 2676361 taataaacac agctattagt gcaattaata aaaagaatac aactccgatg atcattataa 2676421 tcggcattgt catatcaaat tcctcctttt atgttaaatg ggttcatgcg gagtaaccga 2676481 aagaactccg ttgttaatat ctacgactaa caccgttgtc ccgtaactga tctgctgatt 2676541 atcaaaactg accgctgact ttgaaatggt cccgcctatc ccttctatga ccacttcacc 2676601 aaacccgtca accggcacag ctgtaatcac tttaccgagt cttcctctga gatcatcttc 2676661 tctatatgcc aatgattctt ctgcagatga taatggcacc agtacaaaga tgtgaagcaa 2676721 taccaccagc atgatcgaaa ggatgcaaga taaaagcgca atcagcaagc ttgacagagg 2676781 caatacaagt tcacctatat atccgcccgc tgaaaaacat gtaaaaaatg agagcactaa 2676841 tgtcggatta agaaacggaa tgccttctga cagccctgaa aatacatctc cgaaaaacag 2676901 gaataacagc gtaaggctgc ccgcaataat aagcgtataa agatacattg tttgtatagg 2676961 tactccaaat aactccaact tcctcatcct ttcttcatca atgcattgat gaacggctgc 2677021 cgttaccatt tatacgagac acctcgggaa aagtttcaaa attttaagac aaataaccca 2677081 tttgaagtgc tttataaatg ataattgctt atatatatgg taatgtcatt ttaggaggag 2677141 atatgatgag tatctttaat gaagccagat tagaaacgtg gaacgaattg aaaggacttt 2677201 ctgacgaaaa gctgaatcaa aagccttctg ctgaagaatg gagcatacgg gaagttcttg 2677261 accatttgaa aaaaatcgat atgaccgcac aaaaaatgtt gaaggaacgt gtaaaggacg 2677321 ctccgattaa agaaattgaa gaaaaaccgc ttgaagtagc acaggacaga aataataaac 2677381 ggaaagcccc gagtcatctt gagcctgcgc atgattttat ttcaggcagc caaatgaaac 2677441 gtgagcttga tgtggtaaga gagcagctga ctgctgcgat tgcctctctg aaagaagaag 2677501 attttgaaag agtgcttccg catcctgtgt ttcaagagct gactgtcaga cagtggatcg 2677561 attttatcgg ccatcatgaa aaacggcacc tcagccaaat gaaagaaatt aaagaaaaga 2677621 tagaaagggc ctgatttaat cagacccttt ctgcttttcg tttgactttt cgctgatagg 2677681 aatgaacttc tatttcatca cctgtgtaaa cagcaccagg tctctccaca atacagacaa 2677741 tccctctaat gcccagtgcg tggcggacga aagccgacgc cagcttcggt tggtccggat 2677801 aataagactg aatgacttct cccggctgga tacacggatc attttcgccc tcacacagca 2677861 gagccgctcc gctcggaaaa ataatccggc ttccttcttt taatgaagta agatctggca 2677921 taccgctgac tgccacattc gccccgagcc attccggcaa aattctcggc actcccattt 2677981 ttaaagcgat ttcgttgcat tcctctattg aaacaattga aatttgtctg cggttgaaaa 2678041 tttcagtccc tcttgaaaac attggttctc tggctcccgc ttttttggtc aggccaaaat 2678101 gcaagtcgcc ggggatgccg ccataatcaa aatcaagctt gtccatttgc tttgttacga 2678161 agctttttgt atctgcgata tataagcctt ccgcttttgc agtcatacgc ttccacatca 2678221 gctggcacct tccttcttat ctaaaatttc cacctatgct tcattatccc aaaaaatccc 2678281 gctctgtaaa ggagcgggat tttgattata ccgttttagg cgtaaggtta aagcagcgtt 2678341 tgtagatcca gttgtatgct ttttcattta aatctctagg gtttccgaag gtttgcggat 2678401 ctttcattgc ttctttagac aagcgttcga tcatatcagg tgatactccc tgctcttcta 2678461 aagtcggcac ttctaaatct tcgaccagat catacatcca attgacagat gctttcgcag 2678521 cttcttctgt tgtcatcttg cttgtatcaa taccgaacgc tttcgcaata cgcgcaaact 2678581 tctcaggata gcccttccag ttgtattcca tgacagggcc catcatcgcc gctacacatt 2678641 ggccgtgagc gactgggata ataccgccaa gcgtttggct catcgcatga gcagcgcccg 2678701 ctgattcact tccgtaagaa agaccggcaa gcatcgcagc ctgcgccatt ccgtaccttg 2678761 cttccagatc ctctccatca gcaaatgccc tcttgatgta atgagcggca tactcaatcg 2678821 ccattaaggc aaccgcatcc gtgattggct gtgcaaattt cattgtatag cactcaatgg 2678881 catgggcgag cgcatcaatt cccgtcatag ctgttacatg cggaggcatt gaaacatgaa 2678941 gctcaggatc aatgattgtc aagtgcgctg caatcagcgg accgcccgtg ttgaatttga 2679001 attctctttc ttcatctgtg ataaccgccc attgggttac ttctgatccg gttccagctg 2679061 tagtgggaat tgtcgtcagc ggaggaatgc ggttttccag cggttttttc ccatctgccg 2679121 cttcataatc aagcacgctt ccttcgtgag tcgcttctac tccgattgct tttgctgtat 2679181 ccatggagct tccgcctccg actgccacca aaccattaca gttctctttt ttgtaaagct 2679241 cagatccttc attcaccaga cggacaggcg ggtttggctc aactttatta aagagtacca 2679301 cttcaatgcc tgcttcttta agtgattcga ttacgggatc agcaacaccg gctttataaa 2679361 tcccagggtc tgtgacaagg agcgcttttg aaacgcccag tgcagctact tcctcacccg 2679421 tatgcttgat ggctccgatt ccatgcttaa tcacagtcgg aatttcaaat gtgtggaatt 2679481 tctgcatgct ttctaccttc atatttaatg tcatcatcaa tctccccctc ttatgaatta 2679541 aaccagttaa ccgctgccgg ttttgtattg cggtatacat gtttgacttc tgtgtattct 2679601 tcaaggccta tttttccaag ctcgcgtccg aacccggatt gcttatatcc gccccatggc 2679661 gcttgtgcaa agtacggatg aaaatcgttg atccaaacgg ttcccattct caagcgggct 2679721 gctacccgtt cgcacttttc aatgtctttt gaccataccg ctccagccaa gccatagatg 2679781 gtatcattcg caagctcgat tacctcttct tcagagctga aggtttcgac tgtcaataca 2679841 ggaccgaaaa cctcttcctg aacgattctc atgtcagaat tacagtttga gaaaatagta 2679901 ggttcataga aaaagccgtt ttgaagctca ggatcttccg ggcgtttgcc tcctgtctcc 2679961 agcttcgcgc cttcctctat tccgatctct acatattttt ctacctttgc cctgtgctcc 2680021 gccgaaataa gcggaccgct ttctgtctca gcatgaaaac cgtttccgag ttttatgcgt 2680081 tttgcccgtt tgaccagctc cgccaaaaat tgatcatgaa tggcatcctc aacaagcaag 2680141 cgggaacctg cagagcatac ttggccggcg tggaaaaata cagcgtttaa ggcctgatca 2680201 accgcaactt ctaaatccgc gtccttgaaa acaatatttg ggtttttccc gccaagttca 2680261 agggcgattt ttttgacgtt tccgcttgcc gcccgcatga tttttttgcc tgtttcaatt 2680321 ccgcccgtaa atgaaatcaa atcgacgtct ttgtttacgg caagctcgtc gcccactgtg 2680381 gctcccggtc caagaacaag atttgcgaca ccttttggaa caccggcttc ttccatcagc 2680441 ttaaagactt tgattgtcgt cagcggcgta atctcactcg gcttcatgac gattgtgttt 2680501 cctgcggcca gtgcaggggc gattttccag ctcgcttgaa ggagcggata attccatgga 2680561 gtgatctggc cgcaaacccc gattggctcc ctaataattt tgctttctga atcaggaatc 2680621 ggagatgaaa tgatctctcc gccatctttg tctgccaagc cggcgtaata ttgaaaaaca 2680681 ttggcgatat cgtccatatc ggccttgctt tcttcgagtg tttttcctgt atcaagagat 2680741 tcaagctcag ccagctcctc aagatcgcgt ctgattaatt ccgcaatttt cagaacaatt 2680801 tttccgcgtt caagcccgga tagcgatgac cattctcctt tgtcaaatgc tctacgtgcg 2680861 gctgcgattg ctttgatggc gtcctctcgc cctccctcgc ttacagttgc aatttcttct 2680921 tgattaaatg ggttgataat actgcggatc tgttcttttt cggcactgat ccattctccg 2680981 tcaatgaata atgtttgact catataagcc tccttgacgt aaataaagtt tgttaaataa 2681041 aaatttaatg tttttaacaa ccttaatcta acatatggtt tttaaactgt caaagtccca 2681101 ttttgatttt tctttttgac ttttcctcat gtttcgttaa gataaagaac ataaagaaat 2681161 aacttaacga atttaatttt ctaaaggaaa agagggtcag tatggatgaa aatccagaat 2681221 ttgcagctat agaacaggct cgggatcttg ttattgactc cattgctgaa acgatggatc 2681281 tttacggaat tacccgcagt gtcgggattt tatatgggac gatgtatatg agggatgaga 2681341 tgacgcttga cgaaatgcgt gaggagttgc aaatgagcaa accaagcatg agcactggcg 2681401 tcaaaaagct tcaagactta aatgtagtga aaaaaacatt tcaccggggc atccgcaagc 2681461 atacatttgt ggctgagaag gatttcttta aatttttcac aaatttcttt ccacctaaat 2681521 gggagcggga ggttcaagtg aatgtaacag cgatcgagga agctcaagct gatttacaaa 2681581 aggttttatg caaggaagat ctcgatgagg atatcaaaaa tgaagcactg cagttatatg 2681641 atcagctgga aagctctaaa gcttactatg actggctgaa acggcttgct gaatcggtgc 2681701 agaccggaga aatttttaaa tttataccgg tcgaaacaaa gtaaagcaga aaacgcctgg 2681761 gaaactaggc gtttttttga tgtaactact acaaatttga aaaatacggg aaaaacaccc 2681821 catttacttc caaaatattt gatggtaatt ttatgtaggt aaaatttgta tttggccttt 2681881 cagaggaggt gaaaagcggg caggcctgtt taatttatca ttttttaggg ggaattttgt 2681941 tatgaaacgc aaattattat cttctttggc aattagtgca ttaagtctcg ggttactcgt 2682001 ttctgcacct acagcttctt tcgcggctga atctacatca actaaagctc atactgaatc 2682061 cactatgaga acacagtcta cagcttcatt gttcgcaaca atcactggcg ccagcaaaac 2682121 ggaatggtct ttctcagata tcgaattgac ttaccgtcca aacacgcttc tcagccttgg 2682181 cgttatggag tttacattgc caagcggatt tactgcaaac acgaaagaca cattgaacgg 2682241 aaatgccttg cgtacaacac agatcctcaa taacgggaaa acagtaagag ttcctttggc 2682301 acttgatttg ttaggagctg gcgaattcaa attaaaactg aataacaaaa cacttcctgc 2682361 cgctggtaca tatactttcc gtgcggagaa taaatcatta agcatcggaa ataaatttta 2682421 cgcagaagcc agcattgacg tggctaagcg cagcactcct ccgactcagc cttgcggttg 2682481 caactaatgt aaaagaccgg ttaacgccgg tcttttttgc gttttaccct cccctttttc 2682541 tctaatcccc gttatctttt ttctggttta aaatttaaat tgacaaacac tagaaacagg 2682601 agtaaattct tgagtgttca atttcataca gtctctttta ccgcttaatc aaacacgaac 2682661 gggggaacca acgattggct gttttattaa cagccttggg gtgaatctta ctaagtaaga 2682721 gggggtactc tgaatcccta atccgacagc taacctcgta ggcgtataca gagaggaggt 2682781 ctattatcgg ccattctttg caatggtctt ttttgtttca aaaacgttaa ttcactaagg 2682841 gagatatgaa cattgggaag aattaaaaat aagcaatttg ccgtgatcgg gctgggccgg 2682901 tttggcggca gcatttgtaa agaacttcat agaatggggc atgaggtcct tgcggttgat 2682961 atcaacgaag aaaaggtcaa tgcatatgct tcttacgcca ctcatgcggt aattgccaac 2683021 gccaccgaag aaaacgaatt gctttcatta ggaatacgca attttgaata tgtgattgtt 2683081 gccatcggag caaatattca agcgagtacg ctgaccaccc tattattaaa ggagcttgat 2683141 attccaaata tttgggtgaa ggctcaaaac tattatcatc acaaggtgct tgaaaaaata 2683201 ggcgctgacc gcattattca tcctgaaaaa gatatggggg ttaaaatcgc acaaagcctt 2683261 tcagacgaaa atgttttgaa ttacattgat ctatctgatg aatacagtat tgtcgagctg 2683321 ctggctacgc gcaagcttga ttcaaaatcg attattgacc tgaatgtaag agcaaagtac 2683381 ggctgcacga tcctggccat taaacatcat ggagatatct gtctttcccc cgcgcctgaa 2683441 gacatcattc gcgagcaaga ttgcctggtg atcatgggcc acaaaaagga tattaaacgt 2683501 tttgaaaacg aagggatgta gacaaaggtg acacttcaaa aggataaagt gatcaaatgg 2683561 gttcggttta caccgcctca agtgcttgcc attggttttt tccttaccat tatcatcggg 2683621 gctgtcctat taatgcttcc gatttccact acgaagccat tgtcatggat agatgccctt 2683681 tttactgcgg cttccgctac aactgttaca gggcttgctg ttgtcgatac cggcactcaa 2683741 tttacggtat tcgggcaaac agtaattatg gggctgattc agattggcgg gcttggattt 2683801 atgacatttg cggtcttgat cgtcatgata ttaggaaaaa aaatcggctt aaaagaacga 2683861 atgctcgtcc aggaagcctt aaaccagccg acaatcggcg gtgtcattgg ccttgtcaaa 2683921 gtcctgtttc tgttttcgat cagtattgaa ttgatagcag cactcatttt atccatccgg 2683981 cttgtacctc aatacggctg gtcatccggc ttgtttgcaa gtttgtttca cgcaatatct 2684041 gcttttaaca atgccgggtt ttcgttgtgg cctgataatt tgatgagcta cgttggcgat 2684101 cctacagtga acctcgtgat tactttctta tttattacag gagggatcgg atttacggtt 2684161 ctgtttgatg tgatgaaaaa tcggcgtttt aaaacttttt ctttacatac aaagctcatg 2684221 cttacaggaa cgctgatgtt gaatgcgatc gctatgctta cggtctttat tttagaatac 2684281 agcaaccccg gcacgctcgg ccacctgcat atagtggata aactgtgggc ctcctatttt 2684341 caggcagtga cgccgagaac cgcagggttc aattctctag attttggaag catgagagaa 2684401 ggaacaattg tatttacttt attattgatg tttatcggag caggaagcgc atcaacggcg 2684461 agcggcatta agctgactac gttcatcgtg attttaacat ctgttattgc ttacttgaga 2684521 ggtaaaaaag aaacggttat tttccgccgt tccatcaaat atccgattat cattaaagct 2684581 ttagctgtga gcgtcaccag tttgttcatc gtgtttttag ggattttcgc cctgacgatc 2684641 acagaacaag cgccatttct tcaaattgtg tttgaaacct tttccgcatt cggaactgtc 2684701 ggccttacga tggggcttac tcctgaactg acaacagctg gcaagtgtat catcattgtc 2684761 atcatgttta tcggaagaat tggtccttta acgttcgtgt tttcattcgc aaaaacagag 2684821 caatcaaata tccgttatcc tgatggcgaa gtgtttacag ggtgatatca aaaaaatccg 2684881 gcgtgcagtc gccggatttt ttatgattcg atatgagatt gattttgtct tttttcctgt 2684941 tccgcgatga tttcgttatc ctccgcgtta tcacgggtca ctttttgcgt aagaatcgca 2685001 ccaactgcta caagtatcat aacagcgatg taataacctt tttcattgag ttccagatta 2685061 tcagcattat agagtccgat actaaacaaa aatactcccg caaaaaaagt aaaataagct 2685121 agtactgtaa aggcaaccgt gtttctgcgt ctatatttct gcacctttgt tccctcccga 2685181 aagcatagtt aaaaagtgat aacttccgtg gaatattata cctcaaattc cccggaatgg 2685241 aacaaagaat taaaaatacc agtaaaaagg gcttaggttg cctcctttat ttcaacagct 2685301 gaatcatcaa tccagccgat aagtttatca ttgatttgga attggtacca tacagactgg 2685361 cctttctgtt ttttagacac aacctttatg tctttgccga cgtaagattg ggcagaggta 2685421 agccttatgg accgatcatc agtagaaggc ttggaccata cgtcttgaac ggcactgtct 2685481 ttaatagagg cgtttaaatc cacagatttg agggatggat ttacctcatc gtactcatct 2685541 aaatcgtatt tttccacaat agcgctgatt ttgtcagcgt agtcagggtc tgtagcatat 2685601 cctgatgttt gcagggcggt tgccgcttcc ttataattcc ctgcctcaag caccggttta 2685661 tacttctttt tattccacga tgtgccacgg acgaacaatt gggcgtgatc atccatagat 2685721 tcaaaaaacg tgctgtattt tcgaaacttc gcgcgaatgg tttttctttt ccctttttca 2685781 acttcgtccg tttccatcgt gacatgatgg cctttataat tcccttttac gccaaaaagg 2685841 ttgttggcct tagcagccag ttcactgttc ccccagtccg attcgagaat ggcctgagca 2685901 attgtgatgc tggggagaac atggtatttt tcatacaaaa tttgggcatg tccggacaga 2685961 ctgtctataa atacttgctg ttcatcgatt tcttcagttt ctttggatat ttcaatcggt 2686021 tttgataaag ttgtcgctaa aacaaacaga gctagcggaa tcgatacaag gaaaaatagt 2686081 gaaatcaaga gtttacgttt tttaagtttt ttacgggcca tgaaaacctt ccttcgaatt 2686141 aaaagattac gaatgtaaaa gaatctacct tttagaattt tacttgcact tctaatattt 2686201 ttcaattctt tagggataaa gttgggaaaa gattgcaaaa taaaaacctt ttcgctcaat 2686261 gaaaaggttt ttaccatgtt tctatttttg taaatttctg agtgcattcc gatattccgt 2686321 atcatttatt actttatatg atttgacagt tgccttcgac aaaccttgtg ctgagacggc 2686381 cggtttttcc ggagctgttt tcgctttatc atgtggttta tgtgccagct tgtgccccat 2686441 tccagtggca ttcatacaaa atgacaggca gacgagcagc acgctaagga taaaagaaat 2686501 gaagaagaga tcatgataag cagtcatcat agaatcctgt accgaaccgc tttgtctggc 2686561 agcatctttt ttcgtgaaaa agccgatgag aatgggaact cccatataga caaacaatct 2686621 taaaaactga acagctgtca ttctcttgac caaatcaggc agcgggcctc ccatggcagc 2686681 tcccatcagc cctgcggcga ctgtcaggcc tgttcccgct gcaagcatga taaacagtgc 2686741 cgcgaacata taaagagatg atcgatcctg tatatgcagc cattgaaaat tcacaaaaac 2686801 gagaatgagt ccgccgataa taccgagcat ccctggtccg actttatcgt ataacagagc 2686861 gctcaaaatg gccgcgatcg ccactccgat taaaagagtc aagcttaaaa gaatgagatg 2686921 ctcctgagaa atatcataca tttgacggag caagccttga aaagcagaaa ggctgacagc 2686981 taccgttatc gtccctgcag ctatgatcaa taagccgagc accggttttg gcagcagcat 2687041 cagtttaata gatatgaagg ggtttttcac tttatattcc acaatcaata gaccaatgag 2687101 caaacataac gtcaccccga aaccaatcca tacataaccc gatgacagcc cccatttttg 2687161 cagaaaaatg aatgaaaccg ctgaggctgc ggcaaggaag acagataaaa gaattcccgc 2687221 acgatcaagc ggctgttctt gatccgccgc tccgtgatgc tcatcatgaa gaaagaaata 2687281 gctcaccgcg acaccgatca gggacaaggt gccaaagatg aaaaacagcc atctccaatg 2687341 cccgcagctt gttgcaatgg ttcccaggat tgtaccgatg ataacagaac catagaatcc 2687401 cccgatcagc acaagcagtg catagttcct gcgttcaatc gggaatgaca gtacaagcat 2687461 tggaatcata atcatcagca tgacgcctgt tgccgcccct tgtaaaaagc gccctgccgc 2687521 catcaatgca atatcgcctg aacatgcgat gagcagtgag cctagtataa agacaggtaa 2687581 tgaagccaga tagacgggac gagcaccgaa ttttttcctc agcagcggtc ctgccggaac 2687641 taacaaggca aaggccatat tgccgatcaa tatcggattt actgatgtaa agacacttgt 2687701 tccaaccgtt ttctgaacaa ggccttgaac tgacgacaat gccgtgttag acatcaatcc 2687761 cggcccgacc gctaagacgg cgagcaaaga aatcacccaa tagtgttttg tcttcatgtt 2687821 gtcatccctt cctatatgaa tacatgcgaa acacatcatt ttttgaaaac aaaagaagct 2687881 aatagatttt gcataccatt agctttcatt ctaatattct ccctttcagg ggaaatgata 2687941 ttattttatt ataattatgt gaatgaatga gcatataatc aaatattatt tcaaatcgat 2688001 tgtgttttgt caatggagta aatttcaagc acaacataga aagcttgaaa gcttttcccc 2688061 gatattgtgt ctagaactgc acttatgaat ccctgctcgt tccctcaagc gaattaaagc 2688121 aggccgtttt aatcctttca atccactatt ccaactaata aactcaaata agttggtgat 2688181 aagacaacat tttaccccca catttttttg tgttcactgg gcgtttgccg cctctaaatt 2688241 gtatatgggt aaataccatg aattaaccta tgaaatacca atgtaaggga ggcaaaaacg 2688301 aatggaactg tatgagtgta tccaagacat ttttggcggc ttgaaaaatc catcggttaa 2688361 agatttagca acgtctttaa aacaaattcc aaacgcagca aaattgagtc aaccgtatat 2688421 taaggaacca gaccagtacg cttacggccg aaatgccatc tatcgaaata atgaattgga 2688481 aattatcgtg attaacattc cgccaaacaa ggagacaaca gtacacgatc atggtcaatc 2688541 cattggttgt gcaatggtgt tagaaggaaa gcttcttaat tctatttatc gttcaaccgg 2688601 cgaacacgca gaactctcca attcatactt tgtccacgaa ggagaatgcc ttatttcaac 2688661 caaaggttta attcacaaaa tgtccaatcc aacatctgaa cgaatggtgt ctcttcatgt 2688721 ctactcccct cctttggaag acatgacggt ctttgaggaa caaaaggagg tattggaaaa 2688781 ttcatgattg acagataaac tgctcacttt gacttcactc aactggagga ttcagagaat 2688841 gaaacctttt cctcaaaaca aaaaaaccct tatcgaataa gggtttaaag gtatggagcc 2688901 aagggggctc gaacccctga cctctacgct gccagcgtag cgctctccca gctgagctat 2688961 ggccccgtat gtaacgtcat gtttattata gatgatttta ttttgaaaaa caagctgttt 2689021 cctcttgaat tgacagaaaa aataaggctc ggaaaagagc cttatttttc gacttacatc 2689081 atgatcaaaa gtaaaatcac accgagaata attcgataga ttgcaaatgg gacaagtttg 2689141 attttgttaa tcagccttaa gaagaaacgg acgacaaaca gtgcgaccac aaaggcacag 2689201 ataaagccga cgatgaaaaa cggcatcaga tccgaactta agctgtccca atgcttcacg 2689261 aggcttagaa agctggctcc catcatgatc ggcatcgcca taataaacgt aaagtcggct 2689321 gcagctcggt ggtttaatcc gagaataaca ccgccggaaa tggttgaacc cgaacgcgag 2689381 aaaccaggcc aaagggaaag acattggaat aagccgacgg ctatcgcctg tttataggaa 2689441 atgcggtcga gtgtgtctgt cgctgttttc cgtttattga cccagtcagc aaaaagcatg 2689501 aggattgccc cggcaattaa accgatggcc acagttttaa cggaaaataa atattcatca 2689561 atgtaatctt caaacaaaaa gccgagaaca gctgcaggca cgagtccgac ggcaatttgg 2689621 gcaatgctta atttatgtcc ctgctcctgg tcgcttgtaa tatttttttt caagcccagt 2689681 aaatttaaaa ttcggtcttt aaacacgata gctactgcta aaatggagcc tagctgaata 2689741 accaccttga atgagttagc agcttcttct gacatcagat tacttgattt tagccagatg 2689801 tcgtctacta tgatcatatg tcctgtcgaa gaaaccggcg cgtactctgt taatccttct 2689861 acgattccta aaatggcggc tacaaacaat tcccatagag tcatgatttt gattctcccc 2689921 attagacatt tattttttta cataacggga gcttcccata aatggaaagc ccgtcttata 2689981 taactataaa cgaaaatcac actttatgcc ccggcgtatt ttcatttttt tcttcatcgt 2690041 ataaatgtga ctgcatttta aaccagtcaa ataaatgtgt cgtaatgact ttggcaaccg 2690101 catagccggg aatcgcaaga atgattccaa caacgccaaa cagcttgccg gctgttaaca 2690161 gcagaaaaat aatcgtaatc ggatggatgt gaaggttttt tcccataatt tgcggagaga 2690221 tcagcttccc ttcaatcagc tgaacaatcg tccaaacgat caccagctta agcagcatga 2690281 gcggcgatgt cactatggca atgataatcg caggcgtaat ggcaatcgtt ggccctaaat 2690341 atggaacgat gcttgtgcaa gccgcaatga ctgcaagcaa tgaagcataa tccagcccga 2690401 taatcaaata accgataaac agcaaaaacc cgatacagaa gctgacaatg atctggcctc 2690461 tgatataaga gcttaaccga tgattcattt cgcttaagac tgtatatgtc tgttctttca 2690521 atcgagtcgg cacaaacttc agtatgtaga ccggtaattt tcttccgtct tttagcaaat 2690581 aaaatagaat aaacggaacc gtgacgatcg aaatgataat ctcagtcagt gcgccgataa 2690641 aattcccaac accggtaaag gtgctgttca cgatcgtcgc tgcctgatcc gaaacctttg 2690701 tagcaagatc agatatatta atgttcatcg tttgctgggc ctgattgacg aagttgctgc 2690761 caatcagctg tttcgtctga ttttctacga cgtccacata tctcgggata ttgtcaatca 2690821 aactcataat ttgttctttt aagaagggaa tgatcgacac gatcgtgatc gtgatcagcc 2690881 cgataaccaa taggtatagc agcaatatag aatagattct tcttattctt cttctctcca 2690941 gaaaatcgac gactgggttt aacagataaa aaacaatgcc tgtcaaaata atcggaagtg 2691001 atatcgtttt gagcagaaca ataatcgggg tgaaaataaa tgatgttttt gtaaatacta 2691061 gaatatttaa accaatcagc agcagcacaa gcaaaaataa aacaaactta ttatccaaga 2691121 agaatcgctt gaatctgccg ctccatgttt gcaacgtctc cactatcgtt cctccgtcat 2691181 acatagttta attaaattgt acactatcgt ccctataatg aaaaataaaa accgttaatt 2691241 gctggaaaag ctttctcggt tttaacattc tatttatatc tatcatgtga ttttgttctt 2691301 tttaagctat aatttagcta tatcatgcaa aaggagcgat acgagtgata cgttttgcaa 2691361 taataggaac caactggatt acagaccgct ttcttgagtc agcagcggat atcgaagatt 2691421 ttcagctgac tgctgtttat tcaagatcgg ctgaacgcgc tggcgagttt gctgctaaac 2691481 acaacgctgc gcatgccttc tcagaccttc aggaaatggc ggcgagcgat tgctttgatg 2691541 ccgtatacat agcgagcccg aacgctcttc acaaggaaca agccgttctc tttatgaacc 2691601 atggcaagca tgtgctttgt gagaagccgt ttgcttcgaa tacaaaagaa acagaagaga 2691661 tgatctcagc ggctaaggca aacggcgttg ttctcatgga agcaatgaag accactttcc 2691721 tgccgaattt caaagaactg aaaaaacacc tgcataaaat cggcactgtc cgcagattta 2691781 ccgcaagcta ctgccagtat tcctcacgat atgacgcgtt cagaagcgga actgttttga 2691841 atgcgtttca gcctgagctt tccaatgggt cattaatgga tattggcgtc tattgtattt 2691901 atccggctgt tgtgttgttt ggcgcgccga aggatgtaaa agcaaacgga tatgctttat 2691961 cctccggagt ggacggagaa ggaactgtca ttctgtctta cgacgggttc gaagctgttc 2692021 tgatgcattc caaaatctct acttcctatg ccccggctga aatccagggt gaagacggga 2692081 cgattgtaat cgatacgatt caccggcctg aacgtgttga aatccgctac cgggacggcc 2692141 gccttgaaaa catcgcgatc cctgatccta aaccggcgat gttctatgaa gcagaagaat 2692201 ttgtcacgct tataaaagag aataagctgg aatctgaaga aaatacattt gaacggtctt 2692261 tgaccaccgc aaaaattatg gaagaagcaa gaaagcaaat ggggattgta taccctgctg 2692321 atcaagctta aaaaaatccg cccgcgtgca aatgccgcgg cggatttttt attagacaat 2692381 cggagaagat gccttccttt ttaaaagcac ctgttgctca tattctttga tgtcataaag 2692441 ccatgcctct tttaccggaa cgcccatttg ctcacagtag gaatcccaga tggctccgaa 2692501 aggatatgtt ttgaattcct ccatcagggc cagcctttct gtatagcggc cctcttcctg 2692561 caattgtttt aaatatccgt tcgggagaag cagggcatac aataaagctt tgatcatatt 2692621 tctcgttccg atggtccagg cggctacacg gttaatgctg gcatcgaaaa aatccagacc 2692681 gatggctacc ttctcaagag catgatttcg tacaatttca agagcgattt ctctcaattc 2692741 atcatccaaa accactacat ggtcgctatc ccaacgaaca ggccgcgata cgtgcaaggc 2692801 aagcttgtct gtgtaaagca gcatggacga gatcttgttt gataccgtct cagtcggatg 2692861 gaaatggcct gtatcaagta aacaaagctt atgattcgtc aaagcataag ctaaataaaa 2692921 ttcatgagat ccgacaacat atgattcgga gccaagcccg aacagcttgc tctcgattga 2692981 atcaagatta tgttgttcac tgatctcctc tgagaagatc cgatccagtg attcttttag 2693041 tcttttacgc ggtgtcagcc tatcactcgg gatatcctta tagccgtcgg gaatccaaat 2693101 attcgtcaag caaggtgttc ctaattcttt cccgaagtat tccccgatac ggcggcaagc 2693161 gatgcaatgc ctgatccaaa attctctgat gtccggatca gggtgtgaaa gggtgagtcc 2693221 gtcagccgct ttctcatgcg aaaacaaggt tggattaaaa tctaaaccga gaccaaggtt 2693281 ttttgcccat ttcacccagt tttcaaaatg ctgcggcttc aattcgtcac gttctaccgc 2693341 ttccctgttt gtttctgcgt atatcgcatg caggtttacg cggtgctttc caggaatgag 2693401 agaaagagcc ttctccaaat ctcttcttaa ttcttcagga gtttgcgctt ttccgggata 2693461 attgccggtc acgtcaattc cgcctgaaag ctcgccctta tttacttcaa agccttcaat 2693521 gtcgtcaccc tgccagcagt ggatcgaaat gggcacttgc tctaattgcc gaagcgcctc 2693581 ttcaacatca attccccatt tttcatatgc ctgttttgca ctgtcataat tggcttttat 2693641 ggtcatacgg ctctctccct ttatcagttt ttcaatccaa ataaaaaact tcctttagat 2693701 ctatcgcaac aggactgaaa tccgaatttg ttttcattaa tggcgccatc gatttccacc 2693761 atctttggca aacttccgtg tccgccatct ttctccattt ctcttcatcc tctatttcta 2693821 aatatgcaaa aagcctgcct gtttcctcgt ctagaaaaat ggaataatgg tgtgctccat 2693881 gagctttgag tgcttctgcc atctcaggcc aaatgtcatc atgccgctgt ttgtattctt 2693941 cgtacttgtc ttgatggaca aacatgatac tggcttttct tttcaaacct tttcacctct 2694001 tcatcattta gatagcgctt tcaaaacagt ttgctgaaat gactgaatga tcgtgcttct 2694061 atcaatgtct ttaggtgtaa acactttgat cggaaaggaa tttctgacga cttgccgggc 2694121 ttcttttatg tctttgactt ctttggcagc aatcatttgc atcaaaagat ttccggtggc 2694181 agttgcctct atcggccctg catataccgc ttttccactc atgtctgccg ttaattgatt 2694241 taagaaatca ttccgggctc cgccgccgat gatatgaaat tgctcgatcg gtttttctgt 2694301 gattgtttcg agctctttga tggctatcgc atagatgatg gctaaattgc tgtagatgca 2694361 gcaggcaagt tcgcctgcag tacggggaat cttttggcgg gtttgtctgc aataatgttg 2694421 tatttccttt atcatgtttt ctggattcag gaaacgttta tcatttaagt ttataaattg 2694481 ctggaatggt tctgtttttt tggcttcttc tgcaagctgc tgaaaagaat aatctgcttg 2694541 tagctgctgt ttgacttctt gtatcaccca catgccgata atgtttttga gaaagcgaat 2694601 ggtgttgttt gcgccgcgtt catttgtata gttgttttct aaagcaagat cagttattat 2694661 cggtgttttg ttttcaaccc cgattaacga ccatgttccg ctgctgatat acgcccagcc 2694721 atcatttacg cctggcgccg caatgacggc cgaggccgta tcatgtgttg cgactgtcat 2694781 caccttgcac gccgggagat cataatccgg gaaccactca tttcttagct tcccgagttc 2694841 acaccccggt tcagtgagcg gcgcaaattg ctgttccaga acagacacgg cttcaagcaa 2694901 ttcaggatca agatttcccg ttgagacgtt taaaagctgt gttgtggaca cgtttgtgat 2694961 ttccgttaca gcttttccgg ttaaacaata gcctaaataa tcaggaatca tcataatttt 2695021 gtctgtcttt ttcagcagct cacggtcttc ttcaaacaat tgatagatcg tgttgaaagg 2695081 ctgaaattgt attcctgttt tttgataaat tgcggctttt gagagggtat gttccagttt 2695141 gtctattgtg tgatctgttc ttctatcacg gtaggagatt gcttcccgca accgatcgcc 2695201 tttttcgtcc agtaagacat aatcgactgc ccatgtatca atgcctacgg tgcagtgttc 2695261 atacccaagc gtctttactt tttgcagtcc ttgcaggatt tgttttagca aatgatcaat 2695321 atcccataag caatgcccgt ctctttgact gaaaccgtta gcgaacctgt gaatctcttg 2695381 tatgtcaagc ttcccttcat tcagttcacc taccatgatt ctcccgcttg atgcgcctac 2695441 atcaatggca gtataaatca tcctttcacc ctctcttcga aagaggaaca gctgtcacct 2695501 tcaccttttt gtcctcaaga gcttttaccg atgccggatc aagtccagaa tccgtaataa 2695561 ggcggctgac atcttgcagc gaggcgatat gtgaaaactc gcggttcccc catttgcttg 2695621 aatcggccat caaaatggtc tggtccgacc tttcgatcat ccgttttttg agcagcgcct 2695681 gccactcatt tgaatcactc atcccgttgt gtacgtcaaa tcccttacat gacagaaagg 2695741 ttttattgac atgataggtc tcaagtgaac gctctgctaa cgggccggca aatgataatg 2695801 atttttccag caaaatgccg cctgttgaaa tgactgatat gttttcttta ttgctgagtt 2695861 caatagctgc tttcattgag tttgtaatca cggtgagctc aatgtcaggg agtatttttg 2695921 ccatgtacca agcggttgtg cttgcatcga gaatgattcg gtctccgctt tttacatatt 2695981 tggccgcttc gtgagcgatg gctttttttt cgatgacatt cgtgatttcc cgttcagaaa 2696041 aatgaatttc tgattccttc tgctgaatac tgaccgctcc tccgtggctc cggctcagtt 2696101 tatgttcttt ttcaagcttt tcaagatcac gccgaatggt ttcctctgtg actgaaaaaa 2696161 tgtcacttaa ttcggaaacg cggatgcttg aacgcatatt tactatttcc actatttttt 2696221 gctgccgttc tgctactagc atcggtaacg cccttcctca tatcgtagtc cgtcttatat 2696281 ttttatcata gcatatatct aacgcgtaaa agcagcaggg acgccgccgt ctaccgtgat 2696341 catgcagccc gttgtttttt cggctttgga agaagcgaag aatgcaatgg cttcggcaat 2696401 atcctccggg taaatattga cgagcaatgc tgtccgtttc cggtaatgtt cctccagctg 2696461 atccggttca atcccgtacg ccgcggctcg ttcctcacgc cagcttgaac cccagattgc 2696521 cgatccttga agaactgcat caggcaaaac ggagttgacc ctaatgccga attctccgcc 2696581 ttctgctgcg atgcatcttg ctaaatgggt ttcaagcgcc ttaacagagc tgtaggcaga 2696641 ggcgtttttt cccgcataaa ctgaattttt cgatccgaca aataccatgc ttccgcctct 2696701 attttgatgt ttcatctgtt taaacgcttc acgggctaca aggaaatagc ctgttcctaa 2696761 aacattcata ttaagattcc attcttttag acttgtttcg tcaaatgggc ttgatgtggc 2696821 cagcccggca ttattgacga cgatatcaat gccgccgtaa gcaagcgccg ctcgttcaaa 2696881 agctgactgt acgtcttcct cctttgtcac atccattttg acagccattg cccgtccttt 2696941 tccgtatgca tcgtttattt ccccggcaat tttctgtgcg ccttctatat tcagatcagc 2697001 tacgatcacg tgccctccct cagctgcaaa tcggcggcat gccgcactgc cgattccgcc 2697061 ggctcctcca gttatcagcg ctacttttcg ggaaaattct gcttccggcg gggccagcgt 2697121 gagtttatat agttcgagcg gccaatattc gacatggtag gactcatttt catgtaaaga 2697181 aacaaattgc cccagagcgg ttgctccttt cattacggcg atggccctcc gatataaagc 2697241 cccgcttact ttagacatcg cataactttt tcctgtattc accattccga ttccaggaat 2697301 caatatcacc cgcggggcgg attcaaagat ttgatcccca tcctgctgat tgcgtgtaaa 2697361 gtaagcctga tactctgatg taaaggtctc gactcctgac ttgatcagat ctgcaagctt 2697421 gtgcacatct tgagtttccg gattccaatc aatgtacagc ggaacccgtt ttgtgtgaac 2697481 aaggtgatcc gggcatgccg caccgatttg cgaaagtgct ggcgcttgga cactgtttac 2697541 aaattccaag acatcgtcat gatcatcata ggaaaggatc attttctttt cttcacttac 2697601 tgctcctctg atcacaggca tgatgcctgc caagatttgt tttcttttat cctccggcag 2697661 cggctgatac cttttgcctc cgaatacctc atgctgattg atacgatcgt taatatactg 2697721 ctcggcttct tgaatgatgg atatcgtttt ttgataacat gtttcagacg tctctcccca 2697781 agtgactaag ccgtgtttct ccattaatac aagctcggcg tgggggttgt ttgctacgcc 2697841 ttcagcgatc attttagaca aagtaaatcc aggacggacg tatggcaccc atacaaaccg 2697901 atttccgtaa atgtcttcag cgatttgttt tccattatcc gcacagcata tgctgataat 2697961 cgcatctgga tgggtatggt caacatgttt gtatggcaga aaagcgtgta atagcgtttc 2698021 aattgaaggg cggggatgtt tgctgtctat catacaatga gacaggtagt ctaccatttc 2698081 ttcatcgggc atttggtccc ttttaatcag cgggcggata tcatctaatt tcaaaccgga 2698141 aaagttatgc gctttcattg ttgccaaatc cgatccgctt ccttttaccc acatgacttc 2698201 tatttcacgg cctctaaaat ccttttccgt tgttttcata gatgtattcc ccccgcccca 2698261 gttgcagaca gtgcggtctg acccgatcag attggacctg tacaccaatt cctctacacc 2698321 tttaggtagc tgtgcagctc gctctgaatc ccatatatgt ttcaccatat ttgatattcc 2698381 tccataccct tttatttgta tccgttttca ttatatatga tttctgtttg tttttgaatc 2698441 gtttttgttt atttttgctt tttaacaaaa aaagaaagca gcagatatgc cgctttctcg 2698501 tttcattatg attctatttt aaatttcttc gtaatgtcct gaagttcttc cgccatgttt 2698561 gccaacgttt ccgctgaaga gctgatttct tccatggacg caagctgttc ttccgccgaa 2698621 gctgcgatat cctgaatgcc tgctgagctt tctttcgcca ctgcagaaat atcttcaaca 2698681 gcacttgaca cttcctgtga tccggctgac agttgttcaa ccgtcgcgtt caagttttgc 2698741 aattcgccgg aaatttgggt tgtcatctca tagatttgtt taaagctttc cgctgtttga 2698801 tccgtaatct gcaagccttc tttcacttca tgattcacgg attggaacat tgaaagtgag 2698861 gtgctgattt ccctgacaat ctcttgaatt aatccttcaa tttccttggc ggagtctgct 2698921 gattgtacag caagttttct aacctcttcc gcaactactg agaaacctct tccgtattct 2698981 cccgctcttg ccgcctcaat cgcagcattt aatgcaagca ggttggtttg atcagcaatg 2699041 ccgttaatca cattcaagat gcttgtgatg tcttgcgatt ttgtttcaag gcccttcaca 2699101 accgcttccg ctttttgaac ggattggtca attgttttca tctggccgac tgtatgctcc 2699161 accagctttt ctccgctgcc cgctgcctca gaggactgaa tcgatgattt cgtaatggtt 2699221 gaagaggctt gagccacttt tgaaatcccc tcgttcattt gagaaagatg atttgagctt 2699281 gtttccagtt tctcgctttg tgcctcgttg ccatctgaga actgttcgat ggcaagtgta 2699341 atatgttcag ttgccttgct tgtttgggct gcgcttgctg tcagctcctc agaagatgaa 2699401 gcgacgtttt ctacagacgt ttgaataacg cctattacag aacgcaatga tgcagacatt 2699461 tcattaaagc tttcgccaag ctggccaaac tcgtttttcg agtgaatgtc aatgacttct 2699521 gtgagatctc cgctgctgat ttttgcagac gttgagacaa gttttcttaa cggcttggtg 2699581 atggcacgga taatatagag tatgagtatg ccgccgatta ctattgacac gcatagaatg 2699641 ataaccgcag tgttcagcac cgggcttgaa gcatcttgca attcactgac aaaatatgtg 2699701 cccgcgattt tccagccagt cagtttattt gtcgtaaagg ccattttctt ttctttgcct 2699761 tcgaatgtat attcaaatga gccttctttt ttggaatata cttggtttgt ccaatcgccg 2699821 gaaccggttg tccccggctt aatggtcgga tgggcgatat attttttgtt gcctgtcgta 2699881 ataaatgcaa agccttcttt tccgattttg attctttttg atgcagtaag cacttcatcc 2699941 aggtttaaat ctagcgctat aacccctgaa ccgtctttta attgttttga aattgtgaca 2700001 acgatatctc ctgtcgcttc atcggtatac ggttctgaga aaacagcttg tcctttttcc 2700061 gcaaccgcct gtttgtacca gtcacgtcct gtcggatcga aacctttcgg aacaccgcta 2700121 tccggatatt tataaagctt cttatcttct gaggcagcat agattgcgcc tacatcgtcg 2700181 ttaagtgtcg tgtactgctt aaatttctct ttcagtaatg ttttgttttt gcctaacaat 2700241 atgtctttat cgactgtctc actataataa tctattgctt ttactttatc ttctaattta 2700301 ttttgcagcg tactgtttag ttcttcaaca tttcccttcg cactgcttat gagctctctg 2700361 tctaacgcgt tccaagctga ttgataactg aaatatgcta aaaccccaac cggcaaaata 2700421 agcactgcca gaaacgcagc gattagcggt ttgctgatcg atggctgttt gatccattgt 2700481 atgaattttc ccattctcgt tgactcctcc tttaagataa atctaatatc gtcaaactag 2700541 gataaaaggt ttaataaaaa aactaaaaaa aacacccaag cgcaacaagc ttgggtgtta 2700601 aggcttatta ttcaatttta aatcgtttgg tcatatcccg aagctcttcc gccatagagg 2700661 aaagggtctc tgcagacgag ctgatttctt ccatggaagc tagctgctct tcagctgacg 2700721 ccgcgatatc ttgtatatgc gctgagcttt cttttgaaat cgatgcaatg tgctcagacg 2700781 ctcccgaaac ttcttcggag ctggcagaaa gctgctgaac cgtcgcactc atattttgca 2700841 gttcgccggc gatttggttc gtcatttcag aaatgcgttt gaagctcatt tctgttttat 2700901 ctgtgatgtc aagtcctgtc tgcacctctt gattgacaga ttggaacatg ccgagtgatg 2700961 tattgatttc cttcacaatt tcgatgatta atccttcaat ctcttttgct gaatctgctg 2701021 actgtactgc cagttttctt acttcttccg ctacaacgga gaagccgcgg ccgtactcgc 2701081 ctgcgcgcgc tgcttcaatt gctgcgttta aggcaagcag gttcgtctgg tctgcgatgc 2701141 cgttgatcac acgcaaaatg tttgtaatat ctttcgattt cgtttccaat ccgcgtacga 2701201 cttgctccgc ttctttaacg gacttgtcaa tgacattcat ttggccgacg gtttgatgaa 2701261 caagcttgcc gccttcactt gcaatttctg tcgattgaac agatgaatca gtgatcactt 2701321 cagaagcttg agccatattc gtcaacccgt cattcatttg ataaatgtgc tctgctgccg 2701381 tttcaatgtt ttcgttttgt ttttcattgc cgttagaaaa ttgttcaatc gccaatgtaa 2701441 tgtgctctgt tgccttgctc gtttgcgcag ctgatgcagt cagctcctca gaggaagcgg 2701501 caacattgtc taccgaatcc tggatggcgt gtatgagaga acgaagtgac gacgccatat 2701561 tgttaaagct tttgccgagc tcgcccaatt catcttttga acggatatca atggtttccg 2701621 tcaaatctcc ctcgctgatc cgcttagagg aaccgacaag ctgtttcagc ggtgttgtaa 2701681 tcgaccgaat gatcaatgtc atgacgataa tccctatgat aatagctgcg gccaagacaa 2701741 ttaaagcaag gtgaaggaca ggctgggctg cctcatggat ttcatccaaa tacatggtgc 2701801 cgccgatctt ccatcccgtc aacttgtttg tgtcaaaggc catttttttc ttatcgccat 2701861 ccatggtgta ttgaaaatcg cctttatcag cactcaacat cttatcgagc cagtcgcctt 2701921 ttaattcagt tcctgattgt tcattagggt gtgcgacaac ttttttgtcc ttcgtcatga 2701981 taaatgcgta gccttgtgtg ccgatgttga cttttttggt tgttttcagc agattttcaa 2702041 tcgtcatgtt gattgcgata acgcctgaac catcttttgt ctgctgggcg attgtcacaa 2702101 ccatcgtatt tgtcgacgcg gttttataag ggtctgtgat cacgactttc cctttatttg 2702161 caaccgcttt tttgtaccag tcgcgttcaa ccggattata gccgcttggc atcggaagat 2702221 ccggatagcg ggtaaagtgc ccttttgtgt cacttgtata aatggattct acatccttgt 2702281 taatgctgat atattgtgag aatttctctg caatgcttgc attgcttttt gcattgtatt 2702341 tctcttttgt cagccattcg ctgaaataat cagcactgtt ttctttttcg ccgatgctgg 2702401 tgttaatgat ttcgtttaat tgctgtacat tttccaatgc gctccccatc atctgtctgt 2702461 cgagtgagct gctagccgat tgatacgcaa agatcgccaa tatgacaacc ggtatgatga 2702521 ggatcgacag aaaggaaacg agaagcttcc gtgtaattga tctttgtttt atgagttgga 2702581 gtattttttt catcattcat ttctcctttt ttatgctacc cttcatatcg gctggaaatg 2702641 ggtaaatata tacagcaaaa aagaagaaat ttaacaaaag taactaattt cccataaata 2702701 aatagtattt tagacctatt atttgtctac tttaaattgt tttgtcagat cacggagttc 2702761 ttcagacatt ctttcaagcg tcagtgcaga tgaactaatc tcctccatgg atgccagctg 2702821 ttcctcagct gaagcggcga tatcttggat gccatccgag ctttccttag aaatggcagt 2702881 gatatcattt gaagctgcgg aaatttcttg agctcccgct gacagctcct caaccgtcgc 2702941 attcatgttt tgcagctcgg aagcaatttg attggtcatt tgcgatatat gtttgaagct 2703001 ctgtttagtt tcatccgtca tgacaagccc tgtttcaact tctttgttta cggactgaag 2703061 cacgttcagt gatgtgtgaa tttcttttac tatttcactg atcagcgatt caatttcttt 2703121 tgctgagtca gccgactgta ccgcgagctt tctcacttcc tcagcgacga ctgagaagcc 2703181 ccggccgtat tcacccgctc tggcagcttc aatggcggca tttaaagcca aaagattggt 2703241 ttgatccgca atgccgttga tgacacgcaa aatattcgtg atatcctttg atttgatctc 2703301 cagccctttc accacttgtt ccgctgcttt tacggaatgg tcaattgtgt tcatttggcc 2703361 ggctgttttc tggacgagtg tctccccttt gcttgacact tcggttgaat ctgcggatgt 2703421 ttctgtaatc actgctgcag cccgcgccag ctctgccaat ccgtcattca tttcattaat 2703481 ttgttcggtt gtcgtttcta ttttctcgct ttggctttca ctgccgtttg aaaattgctc 2703541 gatagccatc gtaatgtgct cagtggctct gcttgtctgg tctgccgatg cagtcagctc 2703601 ttcagacgag gaggcaacgt gttctactga gtctttgatc ccgtgaatga gcgagcgaag 2703661 cgagtgtgcc atatgattga agctctcact cagaacgccg agttcatctt ttgaattgat 2703721 ttcaatcgtt tcggttagat cgccttcact aattttttca gcggatgcga caatgcgtct 2703781 caatggcttt gtgatggatc gaatcacaaa ataaatcgcc gtcattccag ctccgatggc 2703841 aatcgccaga acgattgaag ccatgatcag aaccctgctt gcagcatcgt gaatctcgtt 2703901 tgcatacatc gtgccgctga ttttccagcc tgttgtttgg cttgttgcaa atgccatttt 2703961 tttctttttg cctttgtacg tatattcaaa gtccccgctt ttatccttgt agagcttatc 2704021 aacccagtcc ccttttagct ctgttcccgc tttttctccg gagtaggcga tgactttctt 2704081 gttttggctc aaaataaaag catagccttc ttttccgata ttgattcctt tcgcggtagt 2704141 gactaagtca tcaattttca tatcaatggc gacaacgcct gacccatcca ccgtttgacg 2704201 ggcgatggtg acgaccattt ttcctgatga aatcgattca taaggctcag tgacaattgt 2704261 tttgccttta ttggccattg cttctttgta ccaatctcgt tccaaagcat taaagtcgct 2704321 tggcatgtca gcgtacggat aacgtgtgaa gtccccgtct ttgccgcttg aaaataccgc 2704381 agcgacatta tcattcattt ggataaattg tttaaattcc tgtttcagct ctgttttctt 2704441 tttatcctga aatttttctg ctgtagccca atcgctgaaa tatgcgaggc ttttttcagt 2704501 agtgctgatt ttatcatcaa tgatgtgatc taatatctga acattttcct ttgcgctttg 2704561 cgtcatctgt acatcaagtg aggcaactgc tgattgataa gcgctaaccg aaagggcggt 2704621 tatcggaaca attaagatca gcaggaaaga aataataagt ctccttgcaa ttgatgatct 2704681 gcgaatagtg gtgagtgttt ttttcatttc cttttgaacc ttctttcaat aatttacaaa 2704741 ttatatcggc ggatcttcct ttaaattaca ttgaaaatgg aggaaaaaat gaaaaatagt 2704801 tctaaattca cctgttaaac taggacttta ttattgttta ccatataaaa aaacagcgct 2704861 ttgatagcgc tgtttttcgg tttttactcg attttaaatt gtttcgtcag atcgcgaagc 2704921 tcttctgcca tctgcgcaag agtcgtcgct gaggaactga tttcttccat ggaagcaagc 2704981 tgttcttcag ctgatgcggc aatgtcctgg atgcttgccg agctttcttt cgacacgtct 2705041 gcaatgccgc tgactgctgc tgaaacatgc tgtgaacggt ctgacagctg ctcgacggtg 2705101 gaattcatcg tctgcagctt gcccgcgatt tcgtttgtca tgctgaaaat gctctggaag 2705161 ctttcttttg tattgtctgt gacaacaagt ccggactgta cttcctgatt gacctcttta 2705221 aacatgtgaa gagaggtgtc gatttctgcg acgatttctt ggatcagctt ttcgatttct 2705281 ttcgctgaat cggctgattg gacagccagc ttgcgcacct cctccgctac gacagagaag 2705341 ccgcgtcctg actctccggc acgcgccgct tcaatggctg catttagtgc aagcagattt 2705401 gtttggtcag cgattccgtt gatgactctc aaaatgcttg tgatgtcttt tgattttcct 2705461 tctaagcctt tgacaacagc ttcagcctgc tgaacagatt gattaatcga gttcatttgt 2705521 ccgactgtct gctgcacaaa cttctcaccc gttccggcga tttccgttga ttggatagat 2705581 gcctttgtaa tatctgacga tgtttgtgag acttgctgga gtccttcatt cattaagttc 2705641 agctgatgag agctggattc aaccttttcg ctttgctcct cgtttccgtt tgagaactgc 2705701 tcaatcgcca tcgtaatatg ctcggtggct ttactcgtct gcccggcaga tgcggtaagc 2705761 tgttcggaag atgcggccac attgttcacc gagtcctgaa tagcgctgat cagagagcgg 2705821 agagattgtc ccatttcatt gaagctttcc ccaagctctc caagctcatc ctttgaatgg 2705881 atttcgatcg tttcggtcag atcccccctg ctgatcgttt tcgatgattg aacaagacgt 2705941 tttaacggtt ttgtaatcga acgaacgata aacagaatta aaattccgcc tgccacaatg 2706001 gaagcaatca gcacaatcat tcctgttgtc agcacagact ttgaggcatc cttaatttca 2706061 tccatataca ttgtgccggc tattttccaa ccagtcagtt cgtttgtagt ataggtcatc 2706121 tttttatctt cgttattaag agtatactgg agttcaccgc tgtcattcgc atacattttg 2706181 gctacccagt cgcctgaaag cttttctcca gccttatggt tcttgtgggc gacataggtt 2706241 ttgttttttg ttgcaatgaa agcataacct tcttttccga ccttgatttg tttcatttgt 2706301 tctaacaatt tatcaatggt aatatccatg gcgacaacgc cagatccgtc cttcagctcc 2706361 tgtgcaatgg taatgaccat gcttccgtca ctcgcagcca cgtaaggatc tgtcacgaca 2706421 atttcaccgc cggccttcat cgcatcctgg taccaaggcc gttgtctcgg gtcgtatcct 2706481 tccggcaatt tttcttttgg cgcttgtaca taagtgccgt tatctgcgcc cccataaatt 2706541 ctggctactc cttgattaat agatacatat tgtgaaaatt tagctttgat ctcttcttga 2706601 tttgatttcc ctttgaatgc ggatctttta agagattcac tgaaaaaggt gactgctttc 2706661 gctttttctc ccagatcatt tgtaacagtt gtattaaatg tatcgacact gtttttcgca 2706721 tttcccataa tttcctgatc cagctttccg ctggcgcttc ggtaagagct aaattctaat 2706781 ataagaatag ggataatgag aatcgcaata aatgagacga ttaatttctt tgaaatagac 2706841 ggtttcttca gccaattgat aaaagtcttc atgtcacttg ctccttcagg tttgatacag 2706901 tatatatcgg ctgcttaaaa aagttttaaa ataaaaaatg gaagaagttc tttttggctg 2706961 tcttctgcct ttttaacttt cattgcccaa gctctttgca tatcttataa aaaacaaggg 2707021 gggctaaaca tgattattgt atcaggacaa ttgctccgtc cccaggatat tgaaaattgg 2707081 cagattgatc aagatctgaa tccgctctta aaagagatga ttgagacgcc tgttcagttt 2707141 gattatcatt caattgctga actgatgttt gagcttaaac tgcggatgaa tattgtagca 2707201 gcggcaaaga cgctgcacaa aagcggggcg aagtttgcca cttttttaaa aacatacggg 2707261 aatacaacgt attggagggt ttcaccggag ggcgccttgg agctgaaata cagaatgccg 2707321 ccttcaaaag cgattcggga cattgcagag aacggcccgt tttatgcgtt tgaatgcgca 2707381 accgcaatcg ttatcattta ttacttggcc ttaatcgata caatcggaga agataaattc 2707441 aatgccagct ttgacagaat tattttatat gactggcatt atgagaaatt gccgatatat 2707501 acggaaacag gacaccactt tttccttgga gattgtttgt attttaagaa tcctgaattt 2707561 gatccgcaaa aggcgcaatg gagaggcgaa aatgtgatac tactggggga agataaatat 2707621 tttgcccatg gtcttggaat cttaaacgga aagcaaatta ttgataagct gaattctttt 2707681 aggaaaaaag gagccttaca gtcagcctac cttctgtctc aggcgaccag actggatgtt 2707741 ccgtctcttt tccgcatcgt ccgctaaaaa gccccatcgc ctattttccg gacgatgggg 2707801 tttcaaatgc ctttcgtttt cgatagaagg gggctgtgcc aaaatattgg ttcgcagccc 2707861 actccatttt ttcaaggtca tttcttgtca cgattggatc ctggctgctc catttgataa 2707921 agcggacaaa atagtagcct ttgataggaa ccattgtaac ttttgagtga ggccagcctt 2707981 caaatacaaa ctcaattttc cctctttttt tataagaata ttgaagaatg ttcatatctg 2708041 tcacctcagt ttatcaagtt acgttcggca aagctcggta cgtttacatc cattgattaa 2708101 ctatccctca tgcaggcttt ccggaaaaca aagggtgagg cgcgtgtctc tttccctcgc 2708161 tttttatttc gcatatggac gaatgccaag cacgccttca ttcgataaag ccgcagcgtg 2708221 ggcgggtgtg acaagccctc cggctatcgg cgcttgttca gcgatcatgc ttttgtcata 2708281 aaaaacagcc tattatccca tcattttgat atagcatgtc cgggtgcgag gcccgtcaaa 2708341 ttcgcagaaa taaatgccct gccacgttcc aagaataagc cggccgtttt ccacaatgac 2708401 atgctgtgaa gctccgaccg tactcgactt catgtgtgca gctgtattgc cctccatatg 2708461 gcggtccagc tcatgttccc acggatatac ctcatcaaac cttctgagca tatctttttt 2708521 gacgtccgga tcggcatttt cattaattgt aatgcccgca gtcgtatgcg gacagtaaat 2708581 cagcgctgcg ccgctcgtta tacctgtttc ttgaagaaac gcttccacct cccgggtgat 2708641 atctatcatt tcatctcgtt tggttgtttt gatttgcagt gttttcagca tttgtttctc 2708701 ctttcgtttg tccgctctca tcgcttaatt cgttctgtgt tctttttttt cctgttaaac 2708761 cgctctcata aacccgataa aacaaaaaaa ctccagtcta aggctggagt ttagcaccat 2708821 agatatattc ttgcttcata cggctttaag agtactgatg tcatatgctt gtgcggctct 2708881 gtttcaatat ttgacaagac gagtgcatct gatgacaatg gcaatccaga gtgcctgaac 2708941 aacgccggtg ttcctgtcag attggccgca atcagtgcag tatggctctc gtttttccga 2709001 agatatgcaa agatttgctg atcttccggt aaaatgagct cgtatgtccc gttaataaaa 2709061 acatcatatg tttggcgcag cttgatcaag cttttgtaaa aatggtaaac ggatgtttta 2709121 tcgttttttt gcgcctcggc attcagccat ttgtaattct cattgattcc gatccacggt 2709181 ttggcctcag aaaatccggc gtatggacca gcattccatt gcatcggcgt tcgcgaattg 2709241 tctcttccct ttttccagac aatcttcatc acatcctcgt gtgatgtgcc tttcgctgtt 2709301 tttgtttcat acaggcgttt caatgcgaca tcatcatagt cctcaataga tggaaaagcc 2709361 acgttcgtca tcccgagttc ctgtccctga taaataaacg gtgtgccttt catgagaaaa 2709421 taaacagcgg aaagcgcttt tgcactttct ttcaggtaca ctccgtcgtc tccccacaca 2709481 gaaactgaac ggggctggtc gtgattctcc ataaacaaag cattccagcc gatcccttcc 2709541 agactgtcct gccagtcagt taaaattcgt ttaaatgcaa cgatatcaat actttcattg 2709601 atctctacat cccacaggcc gagatgctca aattgaaaaa tcatgctgaa tatgccgttt 2709661 ttttctccag cccaatcagc tgcttctttt gcagcgacgc cgtttgcttc accaactgtc 2709721 ataatcggat agcgggaaaa tgtgttttcc ttcagctctg ttaacaaatc cataatgccg 2709781 tcagcattca tatgataagg aaaggaaggg acatagtcca gtccctttgg attcggcatg 2709841 tcaggaaacc cttctttttt cttaatatgc gtaatggcat ccacccgaaa tccgtcaatt 2709901 cctttatcaa gccaccaatt gatcatgtca taaacggcat tcctcacctt ttcattttcc 2709961 caattcaaat caggctgttt tttatcaaaa aggtgcagat aatactggct tgtcttttga 2710021 tcatactccc aagccggccc gccgaaaatg ctttcccaat tgttgggcgt ttttccgttt 2710081 ttgccgtctt tccaaatata ccagtcgcgc ttttccgagt gtatggatga acgggattct 2710141 atgaaccatg gatgttcgtc gcttgtgtgg ttcacaacga gatccataat cagcttcata 2710201 tccagatcat gaatgtcacc aagcagctca tcaaaatctt ccatcgtgcc aaactcgctt 2710261 aatatgtttt gataatccct gatatcatag ccattatcgg cattcggtga atcatacagc 2710321 gggcaaatcc atatgacgtc agcgcccagc tcttttatgt aagaaagctt ggttctgatt 2710381 ccttgaatat ccccgattcc gtcgccattt gaatctttaa aactgcgggg gtaaatttgg 2710441 taaactacgg cttccttcca ccaagccttt ttcatacagc cactccttcc cagtgtaccg 2710501 ttcttatata tcctatgtag aaaaaggtct ttacagcatt gctttttaag aaatgacttg 2710561 atgacacaaa aaacagccgt ttgttccccg gctgtttttt atcaaaaatc agtttttttt 2710621 atttctacaa aacggatgtg gtgatcttcg gcgtcgagga ttttaaattc acagccctcc 2710681 gcgtgtatca catcccctgc tttcagctcc attttttgcg ttagaagcca gcctgcaatc 2710741 gtatcaattt cttcattttc aatcgcaatg tcgagaaggt cattcacttc gtctattagc 2710801 gcttttccat ccatcacata atggtgctcg ccctttttca ggatgtgcgg tgtttcatcc 2710861 tgatcatact catcgcggat ttccccgacg atttcctcga taatatcctc tacagtgaca 2710921 agccccgccg ttcccccgta ttcatcgaca agaatcgcca tgtgaatccg ctccttctgc 2710981 atgcggatta aaagctgctg aacaggaatg ctttcaatga ctctgataac gggcctcatg 2711041 atttgattca gctttatcgg ctggccgaga aaataagctt taaacatatc tttgctgttg 2711101 atgatcccta aaatatgatc cttgtcatct ttgatgacag ggtagcgtgt ataccgttca 2711161 ttaatgatgt gatgaattgc ctcttcaagc gactgctcca gagagataac cgcaatttct 2711221 gtccgcggaa tcataatctc tctcgctacc cggttgtcaa attcaaaaat cttatttaca 2711281 tagcggaatt cagactgatt gatttctccc ttttcatagc tttcagaaag gatcagcctt 2711341 agttcctctt cgctgatgac aacctgatgc tcctttaccg aatgaaagcc aaacaatttc 2711401 acaagaaaac ttgcagagcc gtttaatgct ttaataaacg ggtacgtgat tttataaaac 2711461 cagatcagcg gctttgcaat ccataagctt acagcttcag ctttttgaat agaaaccgtt 2711521 ttcggggcaa gctcccccat caccacatgc aaaaaagtga cgatgataaa tgcaactaca 2711581 aatgtgacaa tgtggttaaa cggttccggt atgcctgtca ttgtaaataa gggatgaaga 2711641 aaacgttcaa atgtaggttc accaagccac ccaaggccga gggctgtaat cgtaatcccg 2711701 agctggcagg ctgataaata ctcgtcaaga ttggagatga ttttatgtgc ggctagtgct 2711761 cggctgtcac cgctttcgat gagctgattg atttttgaac ctctgatttt gacgatcgca 2711821 aattccgctg caacgaaaac agccgtaatg ccaatcaaaa caaaaatggc gatcaattgt 2711881 aaaataagca aaaaaagccc ttaccataaa tggtaagggg ccacctcctt aacgttaatt 2711941 ctcatcacga ccgtttaaga aaatcatcac aaaacgaagt agttcaaaca gggaaaccag 2712001 ggcggcggcc acatacgtta aggcagcagc actcagcact ttatttaccc cattttcttc 2712061 attgtttcgg atgaatcctt ctgacacaat aatctgcttc gcacgtgaac ttgcattgaa 2712121 ttcgacaggc aatgtaatca gctggaaaaa gacagccgct gaaaacagta tgatgccaag 2712181 cccgatcaaa ttcaggctgc cgagaagcat gcctcctaag aaaagcaaag gagctacacc 2712241 ggatgcaaaa ttcacgactg ggaagatttt atgtctcagc acaagcgcac catatgactc 2712301 ctgatgctgc aaggcatgtc cgacttcatg ggaagctacg gatatggcgg aaattgagcg 2712361 gccgtaatag accggctcag ataaacgcac cacccgtctt gtcgggtcgt aatggtctgt 2712421 taaagtgcct cttaccggtt cgaccggcac gtcgtaaaga ccgtttatat ctaaaatccg 2712481 tcttgccgtt tctgcccctg tacgtccgct tgaggcttcc acttttgaat atttttcaaa 2712541 gttgctcttt actttaaatt gtgcccaaaa cgacaatccc aatgcggcta ttgttaaaaa 2712601 tataaacagc attttttcat catcctttgt tcatgatcat ttctctatta cgattatttt 2712661 aatgagtttt ctttctcgtg tacagaaatg cgctttttct tccggcttgg agcacacaat 2712721 ccaatcagca aaaagaacag gcctgctgaa aacaaataaa aggcgaaact gccggccagt 2712781 tctttcagaa aatgaagcca ggagaagctt ccggaaaagt gattatatga attcaaatcg 2712841 aaaataaaca aaatcaccgc ggatgccgcc agctgcgtac cgattaaaac cacgatcgtt 2712901 ctttgaaaga tcgtcatctt tttcatcctt tttgttttag tttatggaga aatccggttt 2712961 tatatgtttt gtacattttt tgaaaaacat caccggaagt gggacatact gttagaaaaa 2713021 agcacgggtg tgatggaagc tatgaaagtg acgagtgagg aaaaggaaca gctgagcaca 2713081 gcaatcgacc gaatgaatga aggactggac gcgtttatcc agctgtataa tgaatcggaa 2713141 attgatgaac cgcttattca gcttgatgat gatacagccg agttaatgaa gcaggcccga 2713201 gatatgtacg gccaggaaaa gctaaatgag aaattaaata caattattaa acagatttta 2713261 tccatctcag tatctgaaga aggagaaaaa gaatgaaatc aaatcggata tttatttcat 2713321 ggctcaggtg gccgttattt atccgaatcg gggttattat tttatgtctg attcttttgt 2713381 tcggccaaat catttatata cttgagccta agcagttcac ttcggtattc gaaggtattt 2713441 ggtgggctgt cgttacggtt tctacagtcg gttatggaga ctatgtgccg cacactccgc 2713501 tgggacaggc agccggaata ctgctgattt tgagcggagc aagctttgtc acagcgtatt 2713561 tcgctacgtt atcagcggcc gcattcagca gacagcatcg ctacattgaa ggaaaagttg 2713621 cttacaaagg ccgggaccac atcattctga tcgggtggaa tgaaaaaaca aaccggcttt 2713681 tgaaggacct tcagcttgcc gccccttcca aaacagtcgt actaatcgat gaatccttaa 2713741 cagaaggccc gcttattgaa aacgttcatt tcatacgcgg gcacgctgcc gatgatggga 2713801 cactgaaacg ggccaatatt actgaagcgg aatcagtgat gattactgcc gatcagtata 2713861 aaagtgaaac tgatgctgat atgctgtcag tgctgactct tttatctgtt aaaggtctta 2713921 atccccttgc ttactgcatc gtcgagattt taactgaccg ttttgtcacc aatgcggaac 2713981 gggcaggcgc aaaccaaatc atcggaactt cagaatttat cagccgggcg atgctgcagc 2714041 attaccaagt caagttacgg ccgtctaaac agcagaacgg aatcaagctg acacttgatc 2714101 agcatgtgga gcttcttgct gttcctgacg aactaaaggg agcggcttac aaaacctgtg 2714161 ttctctattt ccttgatcac aacacaacaa ttataggcat acaaaaaaag gaggggccga 2714221 tgctttcccc tcctcttaca tacaaggtgc tcgaaacaga tcaattcctt gccatctagt 2714281 gtaacagaac atcctccaat tctttcacga gagaggcgcc gatatccaaa aatgccggat 2714341 caatttccgc gtcccgcctt tccggttcgg aaaattgatt aaacagtgat tggaaaggcc 2714401 ctccctcggc gtgatcgtca acatccgcct gaaacacctg tctcagcata aatggcgttc 2714461 cgatccggac ggccgcccct cgttcatcga gactgccctg taccgcattg acgggaattc 2714521 ttaaaaataa atagccgtct ctatcatcaa ttttataatc aaagtagcca tgatcgtatt 2714581 cccagccgcc gtttatcaca taaccgagcg gcttcatcac ttgttccagt tcttgaagca 2714641 gaaaagactg cccatctatc gcggaaggta ttggtatcat cagaatgccc cttttttcac 2714701 ttatcctgtc ccgccgaaca agacttcatt cagaggcgcc tacatggaaa tcgttgtttc 2714761 tttcgcgcgg ccaacaggaa agaaagcgca ttcaattaag aagtaaacag ccattgccgc 2714821 tgcaagccat acagctgaat cccaagacac ataaacaacc gttgcataga gtcctaattt 2714881 agtgaaaaga gtatgggttc gttttaaatg caaaatccga tgtaccgcat cggtaaaaag 2714941 ggcaagcggc aaaccaatga gaagaaagga gtggatgaaa aaatgtgaca gcgtgccgcc 2715001 aaagcttgaa gaaaaccctg tatacacggc atcaaaggag ataaggaaac ttaaaatagc 2715061 tgcagaaaaa ccggcaatga tgagatgttt aaccaattgt ttcatgaaca tcagcacctt 2715121 tctgatttta taaaaagccg accggcaaat gccagtcagc tttctcacat taatcttcca 2715181 gacgtttttc aagctctgct tttttctctt caaagccagg tttgccgagt aacgcaaaca 2715241 tattgacttt atacgcttct acaccaggct ggtcaaacgg attgacgcca aggaggtaac 2715301 cgctcatcgc gcaggctttt tcgaagaaat atacaaggta tccaaaagta tatgcattca 2715361 gctcaggaat gttaacgatt aagttcggaa catttccgtc tgtatgggca agcattgtac 2715421 cttggaatgc ttttttgtta acgaaatcaa cagttttacc ggctaaatag ttcaagccgt 2715481 caagatcgtt atccgcttcc tcaattgtca gttcatgttt aggcttctct acgttcagga 2715541 ccgtttcgaa taaatctctg cggccttctt gtacatactg gcctaaagaa tgaaggtctg 2715601 ttgaatagtt cgctgaagaa ggataaatgc ccttctcatc tttcccttcg ctttctccga 2715661 acagctgctt ccaccattcc gcaaagtatt gaagcgccgg ttcgtagttg atgagcattt 2715721 caattgtttt gcccttatta taaaggacat tgcgaacaac cgcatattgg tatgctgggt 2715781 tatcttccag ttcagatgtt gcaaaatctt tgctcgcatc cagggcgcct ttcatcatgt 2715841 cgtcaatgtt gacgccgctg acagcaatcg gcaagagacc tacagctgtt aaaactgaat 2715901 aacggccgcc gacatcgtca ggaattacga atgattcaaa gccttcttcg ttagaaagcg 2715961 tttttaatgc gccgcgctct ttatcagttg ttgcataaat ccgcgctttc gcttcttctt 2716021 taccgtattt ctcttcaaga agcttgcgga aaatacggaa agcgattgca ggttcagttg 2716081 tcgtacctga tttagaaatc acattaatag agaagtcaac atcttcaaga agatccatga 2716141 cgtctctcat ataagatgaa ctgatgttgt tcccgataaa aatgacttgc ggattgccgc 2716201 gttttgcttt tggcaaagtg ttataaaacg cgtgattcag cgcttcaatc gctgcccgcg 2716261 ctccaagata agaaccgccg atgccgacaa caagcaagac atcagagtca gatttgattt 2716321 tttccgcgct ttttttgatg cgcgcgaatt cttctttatc ataatgttca gggaggtcca 2716381 cccagcctag aaaatcgctg cccgcgcctg ttttctcatg gatattatgg tgtgctgttt 2716441 ttacaaagtc ccgcaggtat gtaagttcat gttcgttgaa gaaagtcaac gcttttgagt 2716501 agtcaaagcg tacatgcgtc attgcttgtc cctccataac ggtataatgt tttcatcttt 2716561 cactttatat gaacttatct gtgaaatcaa gtcaagaaga aagggcggaa tgactggatt 2716621 ccgccctttg ggtttataga gacgcgcgaa ggatggcaag cacgtcatct ttgttcagtt 2716681 tttggaagtt gccgaagccg ccgtgttcca tttccttggc tgcgatatca gcaatcagct 2716741 caagcttttc ttctccaata ttgtaatcag caagacgaga aggtgcaccg aggcttgtcc 2716801 agaacgcaga cagtttatcg attccttcaa gcgcaatttc tttatctgtt ttgccttcag 2716861 tatcaatgtc aaacatgttg agcataaggt ttttaaaacg gcctacattt gtatcaagcg 2716921 tgtatctcat ccaatttggg aacagtattg ccaaaccgcc cgcgtgcgga atatcatata 2716981 cagctgaaac agcgtgttcc attgtatgag aagcccagtc accgaagtat cccatttgga 2717041 gcgtgccgtt taaagcaata gtaccagcat acaaaatcgt ttcacgaagt tcgtagtttt 2717101 ccagatcttc aagaagctta ggagctgttt cgatgaccgt ctgcaaaaca gcaaagcaca 2717161 ttctatcctg aagcggcgtg ttttcaacat tatggaagta ttgttcgaat acgtggctca 2717221 tcatgtcaac catgccgtat actgtttgat tttctggaac ggtgaacgta ttttcagggt 2717281 ctaaaataga gaaacgcgga tgagtgacat tgctgcccca tacaaatttc tcgtttgttt 2717341 cccagtttgt aatcacggaa tcagggttca tttcagaccc tgttgcagca agagttaaaa 2717401 cagtgccaaa cggcagcgca tcctccgctg ttactttttt gctgaaaata tcccaagcgt 2717461 caccgtcata tttgacgcca gctgcgattg cctttgtaca gtcaatcaca ctgcctccgc 2717521 cgacagcaag cagaaaatca atgtcatgct ctctgcaaag tcctatgcct ttttccactg 2717581 tcgcaagacg cgggtttggc tctacacctg acagctcatg aacaacagcg ccctcttctt 2717641 ttaaaatgcc tgtgacttga tcataaaggc cgttgcgttt aatgctgccg cccccgtaaa 2717701 caagcagtac attcttgccg tatcgtttga attcttttct taattgttca agctgacctt 2717761 ttccaaaaat cagctttgtc ggattataat aagtgaaatt ttccatagta aaacctccaa 2717821 atgatgctgg taaaaaacag attttccatt gtaacataag ttgacaaaaa agaaaaaggg 2717881 aagcagccaa acggctattt cccctttttt tatagtgatg ctttcaaaat tgacagcaca 2717941 tcttctttgt tgagtgattt aaattggccg aatgtaccgt tagccattgc cttgtcagcg 2718001 attgtgtcaa gctgctcatc attaatatca taatcagcaa gacggttcgg agcgccaaga 2718061 cttgtccaga atgcggacag cttatcgata ccttcaaggg caatttcttc atccgtttta 2718121 cctgcttctt caacatcaaa cacgcgaact gcaagctgtt tcatgcgggc agggttttca 2718181 gacaatgtgt gtctcatcca attcgggaac agaatcgcca gtccgccggc atgcggaata 2718241 tcataaacgg ctgatactgc atgttcaata ttatgagtag cccaatcccc tcttgccccc 2718301 atagaaagca tgccgtttaa tgcgattgtt cctgtgtaca ggatcgtctc acgcaattcg 2718361 taattttcga gatcattgat cagcttaggc gctgtttcaa tgactgtacg caaaagtgat 2718421 tcacacatgc ggtcctgata cggcgtgttt gatacatgat ggaagtattg ttcgaatacg 2718481 tggctcatca tgtcaaccat cccgtagatc gtgtggtttt taggtacggt gaatgtattc 2718541 accggatcaa gaatcgagaa tttagggaat acgagcgggc tgccccagcc gtatttttct 2718601 tttgtttccc agtttgtaat aacagatcct gagttcattt ctgaaccagt tgcagcgaga 2718661 gtcaataccg ttccgaatgg caaagcatct tttggctgat gctttttcgt aacgatatcc 2718721 cacgcatcac catcatactt cgctcctgcg gcaatcgctt ttgtacagtc gattacgctt 2718781 ccgcctccga cagccagcaa gaaatcaatg ttttgttctt tacagatggc aacaccttta 2718841 ttaacagtcg acacacgagg attcggttcc acacctgcta attcatgcac ggtcgctccg 2718901 gctttattca gctgttcaat cacttgatca tacaggccgc tgcgtttaat gctgccgcct 2718961 ccgtacacaa gcaatacgtt ttttccgtaa ggtttgagtt cctccggaag tctttccact 2719021 tcgccgcgcc cgaaaattaa tttggtcgga ttccagtatg taaagttttg catgacatct 2719081 cctccttaga ttttttatta tgcagaatgt cctcaccaca tgtaaagcaa tcagctctca 2719141 ccgatcagca taccagatgg ttttattttg caaggtgctg ggaaagaagc tgatataagc 2719201 gagggcaggc cagcttccct catatggaga atgcatgtat agattctcca atatgtcaca 2719261 atctataact gttttaataa ttcatggagg aggttgcaaa acatgagtac cattcaaaga 2719321 atttgtcttg tattaaccat cattggcgcc attaactggg gactgatcgg atttttccaa 2719381 tttgacttag tagcggctat cttcggcggc caagggtcag ctctttcccg aatcatttac 2719441 ggacttgtcg gaatcgccgg cttaatcaac ctcggtctgc tatttaagcc aaacgaggaa 2719501 agatcacgtg aagaagcagc aaatcctgaa atgcgatagg atatcaatca cgctgaaata 2719561 ggattttgca tgaaatcaaa agcaccgaac attcctgtcc ggtgcttttt tcatgcttat 2719621 tttttgataa ggtctttgcg gttggacatt tcgatccact cttcaagctt atcttttaat 2719681 gtgttgaaac cttgtggtgt agaagcttct tcgcttactt gagcagcttt aggttttctt 2719741 ggtttgcttt cttttttctc aggcgcagct tgtgtcgcac gaattgaaag gctgattttg 2719801 cctttttctt catcaacagc aagtactttt acttgtactt cgtcgccaac tgaaaggtgc 2719861 tcgttgatat cttttacgaa accgtgagtc acttcagaaa tgtgtactaa accttgagtt 2719921 tcttcatcta atgcaacaaa cgcaccatac gcttgtaatc ctgtaacttt accagtgtaa 2719981 acactgccca cttcaaattt tgctgccatt cataacaact cctaagttaa attaaatatc 2720041 tgtttatacg caatttaaaa ttatatcaca catgtcttat ttccgcaaag aaaacttttt 2720101 tataaaaaat caggtttatg cacagcaaaa agggggtaaa ctgaaaatac caaaggcttt 2720161 ctagtattcc ccccttttat tggatgcgaa caaaaggttc gtatcttttt ttatgttgtt 2720221 ttgtgcagga agcgtttcat tctgactaac gcttcttgaa gctgttcaat cgaggttgcg 2720281 tatgaacaac ggatatatcc ctcaccgctc ggaccaaaca cacttccagg aacaactgcc 2720341 actttttcct gcgtcagtag ctcctcggca aactgttctg aactcattcc catgcttttg 2720401 atagatggaa aagcatagaa agcgccgccc ggatgatgac agctgagacc gatttcattg 2720461 agcgattcta caaacagatt ccgtcttctt cgatagcttt ttttcatttt ttctacgtct 2720521 tccatgccgt tcttcaggcc ttcaagggcg gcaaactgcg ccattgcggg cgcgcacatc 2720581 atcgcatact gatgaatttt aagcatggca tcccgaagca aggatggtgc cgcggcaaaa 2720641 ccgagcctcc agcccgtcat tgcaaatgct tttgaaaagc ctgagatgac taccgtccgt 2720701 tccttcattc ccggtaatgc cgctatactt gtaaattcct catcatatgt cagctccgcg 2720761 tagatctcgt cggctaagac gatgacatca tgttttttgg caaactcagc aatctcattc 2720821 agctcttcct tcgaataaac cgaacctgtc ggattcgatg gtgagcagat gagaatggcc 2720881 tttgtttttt cagtgactgc cgcttcaaaa tcagcagccg ttgctttaaa tcctttgtct 2720941 gccgttgtat gaacgtgaac cgggataccg cctgccaaag aaacaagcgc atcgtacgca 2721001 acaaaacacg gctcaggaat gatgacttcc tcacctggat tcacaatggc gcggatcgca 2721061 atatccaaag cctgacttgc ccccactgtc acaatcagct cattatctgg cgagtagcta 2721121 aggtcaaacc tgttgctcaa ataacggctg atttcctccc gcaatgagta taaacccgca 2721181 ttggccgtgt atgacgtata tccttgttca agagagagaa tgcttgcttc gcggacattc 2721241 catgcggtaa caaaatcagg ctcgccgacg cctaaagaaa tgacgccttc catcgttgcc 2721301 gccaaatcaa agaatttgcg gatgccggat ggttttattt gttgtacata gtctgataaa 2721361 tacgaagtca tttacggtga caccacgatt cttttgtcgt cgtctcctgt ttcaaacact 2721421 ttgccgtcat gcttgtattt tttcaggata aaatgggttg tcgtagatac aactgaatca 2721481 agcgttgaga gtttatccga aacaaaacgc gctacgtcag acatcgaatt gccgcgaatc 2721541 acgacagaca aatcgtatac gcctgacatc aggtaaactg attcaacctc ttggaatcgg 2721601 taaatccgtt ccgccacttc atcaaaaccg acgccccgct tcggcgttac tttgacgtca 2721661 atcatggccg taacgccctc atgtccgtcg acttttcgcc agtcaatcat agcggaataa 2721721 tcgataataa ccttttcttt ctccagtttg tcaataattg ttttcacttc atttacaggg 2721781 atgcccgcca tctttgcgat tgtttctaaa tcggcgcggc tgttttcgtc taaaatttct 2721841 aatatttctg tttctttttc tgtcaatttc atttgattca cacctttgca atgtcaagaa 2721901 atctcatgac attatatcac gttttttgac gaatgctaag aaaaaacgag gagaaacttc 2721961 cgctagaatt gacaatttca gggcataata caaccatcaa aaaaagggag tgacacagaa 2722021 tggaggcggt ttcaccaata aggcggttta cggtcgatgg agtcaatgta tactacgaac 2722081 attatcaaaa tcccggcagg caaacgctgg tctgcgtaca cggtttttta tcatctgcat 2722141 tcagcttcag aaaagtaatt cctctccttc gggacaagta cgacatcatc gcgcttgatt 2722201 tgcctccttt cggccaatct gaaaaatcaa gaacgtttat ctatacctat caaaaccttg 2722261 ctaagcttgt cattgggatt ttggagcact tgcaagtgaa acaggctgtg cttgtcgggc 2722321 attctatggg cgggcagata tcgctgtctg ctgctctcca aaaacctgag cttttttcaa 2722381 aggttgtgct gctttgcagt tcagggtatt taaaacgttc acacccgacg attattttcg 2722441 ggacccatat cccgtatttt catctttaca tcaaacgctg gctctcgaaa gaaggcgtga 2722501 tgaaaaattt attaaatgtg gtgcatgaca aatcgctgat tgatgaggag atgattgacg 2722561 gctatggcag accgtttcag gacgagcaga ttttcaaagc catgacaagg tttatccgcc 2722621 acagagaagg agatttagaa cccgagcaat tgaagaaaat gaacaagcct gctctattga 2722681 tttggggcga ggaggatcga attgtcccaa tggagatcgg taaacggctg cacgcagatt 2722741 tgcctaattc cgtgctgtac tcacttggcc agaccggaca tctggtgcct gaagaacggc 2722801 ctgaacttat ttctgaacac attgctgatt ttatcaaata acaaaaaaac cggtgctgaa 2722861 ccggtttttt taaggcgtgc aggagctgct gtttttaatg aataaaagct ggccagccac 2722921 ttcccggcag ctggcgatcg gcagcgtttg ttcaaaagaa gtttcaaata tttgctgaat 2722981 gcttttcgcc agcaagtcgg gatcgttttc atcatagact gcctgcacga catcaacagc 2723041 ctccgtttcg taaaactctt ctccatattt aaacgggtcc catttggcaa tgatcttaat 2723101 catttccctg accgcatgac tttcttccat attcatcacc gcttataata aaatttgcag 2723161 ttctatctta tcatagtgaa gcttagaaga ataaacatac atgagggggt aacagaatga 2723221 actttgataa acgagaagaa cgccttggca cccaatcggt caaatgggat aaaacaggcg 2723281 aattatttgg cgtgacagac gccctcccga tgtgggtggc agatatggat tttcgcgccc 2723341 cggaagcgat aactgaagcg ttaaaagagc gtcttgacca cggtattttt ggttatacaa 2723401 ctccagatca aaaaacgaag gatgctgtgt gcggatggat gcaaaacagg cacggctgga 2723461 aggtaaatcc ggaaagcatc acattcagcc ccggcgttgt aacagctttg agcatggcgg 2723521 tacaagcttt tacggagccg ggcgatcaag tagttgttca gcctccagtt tatacgcctt 2723581 tttaccatat ggtggagaaa aacggccggc acattttaca taatccgctg ctagaaaaag 2723641 acggcgcata tgcaatcgat tttgaagatt tggagacaaa gcttagtgac ccaagcgtta 2723701 cattgtttat tttatgcaat cctcataacc cttctgggcg ttcatggagc cgggaagatt 2723761 tactgaagct aggcgaattg tgccttgagc atggcgtcac agttgtatcg gatgaaatcc 2723821 attccgattt aatgctgtac ggacataaac acacgccgtt cgcttcgctc tctgacgatt 2723881 tcgctgatat ttccgtgaca tgtgctgctc caagcaaaac atttaatatc gccggattgc 2723941 aggcttcagc gatcattatt ccggatcgcc tgaagcgcgc caagttttcc gcaagccttc 2724001 agcgaaatgg tttaggcgga ctgaacgcgt ttgccgtcac tgcaatcgaa gccgcgtatt 2724061 caaaaggcgg accgtggctt gatgaattga tcacttacat tgagaaaaac atgaacgaag 2724121 cggaagcctt tttgagcacc gagctgccaa aggtcaaaat gatgaagccg gatgcatcat 2724181 acttgatttg gctcgacttc agcgcttacg gcttgtccga tgcagagctt cagcaaagaa 2724241 tgctaaaaaa aggaaaagtt attttagagc ccgggacgaa atacgggcct ggcggagaag 2724301 gatttatgcg cctgaacgcc ggatgctctc ttgcaaccct gcaggacggc ctgcgccgca 2724361 tcaaagccgc attatcgtaa atatagctgt aaacgccttt acgtcttcat ttgtaaaggc 2724421 gttcttaata aaggaatttt atattttact tctaatattt agtgttataa tagattcata 2724481 ttttatacga aaggatttca cacgaatgga aattctaaaa gactatcttc tgcacatctg 2724541 ctttattttg tttcctattc ttctttacca agtgttttgg cttggaaaac ctgcgattct 2724601 tgtgccaaaa ataaacagcg gtttggtcac gctcttcgcc tgcggcgcct ccgttttatg 2724661 cattattttc ccgattcatg aaatggacta catacaatac ggccttcaga tgattcccgt 2724721 tatcatttgt ttattttaca ttagtaccgc ttccggactt acagtcgccg catctgtcct 2724781 atgttttgaa ctgctttttt acgaaccttc cgcaatgttt gttttcactt tgctgccttt 2724841 tcttatcatt atcccaatct tatttcagaa aaaatggcca ttcatgtcca aagcgaaaaa 2724901 actgctgctg tctttattga tcagctgcgt ggagattttc ctatttttcg cctcaagctg 2724961 gattctttcc gccttgaata ttttaaattt tcaaaaatca ggaattttcg tttacgaggc 2725021 ggcagtctca gggcttttcc gctccagtgt tcttctatta agcatctata ttatcgaaag 2725081 catcgccgaa aatatcgccc tgcgttcaca gcttatccat tctgaaaaaa tgacgattgt 2725141 gagtgaactg gcagcgagcg tcgcccatga ggtcaggaat ccgctgacag ttgtccgcgg 2725201 gtttgtccag ctgcttttta atgacgaaac cctacaaaac aagtcgagtg cggattacaa 2725261 aaagcttgta ctgtcagagc ttgaccgggc gcaaggcatt atcacaaact atctcgatat 2725321 ggccaaacag caattatacg aaaaagaggt ttttgaccta tctgccctta tcaaagagac 2725381 aagctccctt atggtgtcgt acgccaatta caagtcagta accgtcgagg ctgaaacaga 2725441 accggacctt ttgatatacg gagacgcaac aaagctgaag caggctgtca tcaacctgat 2725501 gaaaaacagt attgaagcgg ttcctcacgg gaaggggatg atccacatat cagccaaaag 2725561 aaacggccat acgatcatga ttaacatcac agacaatggg gtcgggatga cagaccatca 2725621 aatgcaaaaa ctcggcgaac cttattattc cttaaaaacg aacggaacgg gactcggcct 2725681 caccgtaacc ttttccatta ttgaacatca tcacgggacc atttcattta acagcagctt 2725741 ccaaaaaggc actacggtga ccattaagct tcccgctgat cttcctcact agcaaatcga 2725801 ttggaacttt aatagaataa atgcgaggtg atgacagatg agcacgtttg agacaggctc 2725861 tatcgttaaa ggattttaca aaacaggtgt atacatagga gaaatcacgg cttgcaggcc 2725921 gcagcattat ttagtgaaag tgaaagcggt tcttacccat cccgctcagg gagaccttca 2725981 tcatccaaaa caggcggatg tgccattttt tcatgagaga aaagcgctcg catatggtga 2726041 acagaccaat atcccccacc atatggtgaa gccttatgac ggtgaagtgc cggattatac 2726101 cgaatctctg cgggaggcga cagcacagat gagagccaaa ttgaatgagg atggttcgga 2726161 gtgggcaaag cgctcccttc ataatctgga cattttagaa aaagaatatt ttaaccggcc 2726221 ataacccagt ctgacaaaag attgggtttt ttacgtcgcg cgcttcaaca gttcggttaa 2726281 atcgattctc tcgccgattg tgggcggttt tggcttttcg agatactgct tatcctgctc 2726341 aacaagctta aaaagtttat atgctgtgag agcatcatca agcgctttat gatgggtgcc 2726401 ggttccggaa tctccatact cttcggcagc tttccataaa cccgtcaatg tccggtctcc 2726461 aaaaaagttt ttgtattcaa gcgataaatc tctcatttct cccttaaacg ggaaagggat 2726521 atggttaaac atacagtttt gcttcagcac tttcatatcc atgtttcccc acgtaataat 2726581 tgtgctgttt ttctcaggat ccagctcgtt tagtttacgg atgaaatcct cgaatctcat 2726641 tccttcgtct acctgttttt gggttatttt taaaaatgat ttgcagcgtt tcgtaagctt 2726701 cgggaacttt ttcggtctaa catagctaga aaacgtctca accacttcat catcaatcga 2726761 ctttacaatt ccggcttcaa tgatttccgg gaagaagttt tgaggactgt actttccatc 2726821 aggcattgta aattcgaaat caataatgag taagctgttt gtcgtcacct tttacacctg 2726881 cctttcctcc gatcagaaaa tgctatcttt atagtatatc aattcccctt ctcgacattt 2726941 cttcattttc taaaaataat gaattttccc agccgcttcg tttcttttaa attgtgaatc 2727001 gtttctttat aattagtaag gaacccgaaa taataagaag gtgatgttat ttctatccgt 2727061 aagaaaaact ttgtcattgt gtggctggcg aacttttttg tctccgctag cacaacgatg 2727121 atcgttcctt ttctctcctt atacattgag acgctcagct ctttttcaaa cggctttgtg 2727181 caaaggtgga gcggctatgt gttcggcatt acatttctca tggcgttttt ggtatccccg 2727241 ttttggggac ggttcggaga caaacgcgga tacaagaaaa tccttatggc aaccggaaca 2727301 ggcattgccc tcagcatttt cttcatgggc tttgttacat cggtgtacca attgtttttt 2727361 ctgcgtatgg caatgggtct tgtaaccgga ttcatcccga catctcttgc gatgatttcg 2727421 gcacagactc cgaagagctc agctggcaaa acactcggca cgctgcaaat ggggcaagtg 2727481 tccggaagct tgttcggccc gcttttggga ggcatgcttg ctgatcgttt cggctttacg 2727541 tatacctttt ttatcacatc ctttgtgatt ttctcgtctg ttcttctcgt gttatttggt 2727601 gtcaaagaaa agcatcttgc agagaaaaca gccaaacgta cgtcttactc gagaaaagaa 2727661 gtgctctcct atatttttca ccatccggcg ctgtgggtca tgatgctgtt aaccatgctg 2727721 attcaaacag gcaatttcag tatccagccc ctgctcgctt tatatgtaaa tgagctgcac 2727781 ggacctgtca atcttgcctt tttctccggc atggcatttt cagcaacggg gctcggaagt 2727841 ttgctgctgg ctagaaaatg gggtgatctg ggcgaccgct acggccaccg ccgcatttta 2727901 atcggacttt tgctcgccgc ctctttcttt tttattccgc aggcgctcgc gtcctcactc 2727961 agcgtgctcc ttgttttcag atttttattc ggaatggcga tgggcggttt gctgccatgc 2728021 attacggcag cgatccgcgt tcaggctccc ggcagcattc aaggtgaagt tctcggctac 2728081 aatgtcagct ttcgcttttt aggaaacgtg ctcgggcctc tgctcggcgg aatcatatcg 2728141 agccatttta ccatttcggc caccttttac gtcacggcgt ttctcttttt cgccggcgcc 2728201 tgcatgcttt ggatcatgca gaaacttcgg aaagattctt atgccaaagc aagctgattc 2728261 cgagaaaaaa ctaaggaatc ttctaaattt aaccttctcg taatctcaaa agaatggtac 2728321 gatatggcta gaatttagga gaaaagagag tgaccatgtt acgaaaaata atcggatgga 2728381 ttttgctcct ttgcataatc ccattgtttg catttacagt tatcgcttcc ggaaaagaag 2728441 taaaacaaat gaagtccctg gatcaggtgc ttgataaaaa tattgatctg aaagatatca 2728501 gccttgttca gaacagctac atgtatgaca gggacggctc ccttgtctcg gaaatcgtca 2728561 gcgaccacga aaaccgtgtg ctcgttccat ttaacaagat tcccgaggaa gtcaaacaga 2728621 ttttcttaac atctgaggac cgccattttt acgagcataa aggctttgac tttatgggaa 2728681 tggtgcgggc tactgcttct aacgtaaaag acaagaaaat tgaccagggt gccagcacca 2728741 tcacacagca gctttcaaga aacttgtatt tgagccacga acgctccttc agccgcaagc 2728801 tgacagagct cgcgtattcc tatcagctgg agaaaaaata tacgaaaaat gaaattcttg 2728861 aagcttactt aaataccatt tatttcaaca acggtgttta cggcgtcggt tcagcagctc 2728921 aattctattt cagcaaaccg ctgaaatctc tcacagtggg agaaatggct tttatctgtg 2728981 ctatacctaa taaccctaca ttatatgatc ctctcaagca ttttgactac acgaaaagcc 2729041 gtcaagaacg tttacttaaa gggctaaaag atgccggggt cattacggac aaagagctga 2729101 aaaaagccgt aaaacaaaaa atcaaactgg atgttgaaaa aagagaagac aaatatcctg 2729161 actacgtttc ctacgtcaat gatgaattca ctcagctggt gtctgaatca gaaggctttg 2729221 ataaacgcct tcaaaaagca tcaggaaaac aaaaagaaaa gatcgagaac gagctgtccg 2729281 caagagtcag cacgctgatg aaagacggag tgaaaattta tactgcactt gatccgtaca 2729341 tgcaaaatca agttgtggca caaatgaatt ccaagctccc gtatgcggac gtacagggcg 2729401 gagcggctgt gattaatcac cagacgcatc aaatcattgc tctatccggc gggaaaaact 2729461 atcaaaaata tgactttaac cgcgcctacc aggcgtacag gcagccgggt tcatccatta 2729521 agccgcttct tgattacggc ccttatattg aacagaccgg cgcgacaaca agcagcacca 2729581 ttgatgccag caagttttgc agcaaagact actgtccgca aaactacaat aaccgcactt 2729641 acggcacagt gacgcttgat acggcgttta aaaattcata taataccccg gctattagaa 2729701 tgctcgaccg cgtcggcatc caaaaggcat tcagttatat tgagccgtat cattttgcca 2729761 aacttgtcga cagtgactat cttcttccgg cggcgcttgg cggatttaca aacggcatga 2729821 cgcctcttga gatgacaaag gcttatacga cattcggaaa cagcggaagc tatacgccga 2729881 gccatgcgat tacaaaggtg acagacctta aaggaaaaac actttataaa tggaatgata 2729941 aagcgactca aatattcagc gtccgcacga acatgcagct gaaaaaactg atgtcttccg 2730001 ttgtgaaaag cggaacaggg aaaaaagcat atttcaatgc gccttacatc ggcggtaaaa 2730061 ccggaacatc aaatgattat cacgatatgt ggtttgtcgg cctgactgat acgtatacaa 2730121 tgggtgtctg ggtcggaaag gatacaccga ccagcgttga atatcttcac agcatcagcc 2730181 ctcagctttc catctggaaa ggaacgctgc aagcggctta ttaaaggatc ggaggggata 2730241 tggagtgact tcagaacaaa ttccaaatcg cgttttgctg tttgacggtg tctgcaattt 2730301 atgcaatggc gccgtgcagt ttatcattaa acgtgatccg gacggattga tttctttcac 2730361 atcgctgcag tcggaaacag gacagagcct gctgaaaaaa agcgggcttc cgactgatcg 2730421 gtttgacagc tttgtcttta ttgaagacgg ccaagtgtac acaaagtcaa ctgcagccat 2730481 taaggttttc aggcatctgc gaggcccatg gcggctcttc gtcctttttt tcgcagtgcc 2730541 gaagcctgtc agagatatgg tctattcttt cattgccaaa aaccgctata agtggtttgg 2730601 caaaaaaaat gaatgtatgc tcccctcccc ttccattaaa aaaagatttt taccgtaaat 2730661 aaaaaatggc taggaagcta gccatcacag attgttgaca aaatcctaaa acggcttcgt 2730721 tttaggattt tgtcatctat tcagcgtgat tgaaaacttt tgaagttgtg aaacggcgga 2730781 aacctgagaa tctagccgcc gtttcattgc gtacagagca cgaagcgcaa atctgaccac 2730841 caaacgctga aatggctagc ttacacaggt aagctagcca ttatgctatt ataaagcttg 2730901 ataaatatga acagaatacc gataacaaag gtaaaccaaa acagcagttc caatagaatg 2730961 aatccaacta atgacatgag agaaagcgtc gaataaatcc ggtatacggt aaacacaaag 2731021 taagcgagcg tgacgaccgc aaaccagatc acaatccaaa tgacattttg caagagcaca 2731081 aaggataaaa tcccgccgcc caaataaatc atggaaccca ttctgagttt tttcaggttg 2731141 ttcccttccg gatcattagc aaaaaacagc aatgacagct cggtcacggt atttgcaatt 2731201 aatttcagag cggacagaac cataaaatat aaaagtgcaa aggcagcaaa taacgcaagc 2731261 ctgattcctt tctctgaaaa ataatcgagc attccatcat acattccaaa tgaagacagc 2731321 atcttcaacg cataaagtga agttgagatg gataaggacg aactaaaaag caggatcgca 2731381 atcagcggaa aatatcctgt caaataagta tttttcatat aaaaaagtcc ctttctataa 2731441 tctacctcat ttattatgga ggacttaaaa cacattgaca agataaatta ttccattttt 2731501 tctccttttt acgaattacg ggcccaaatc ttcacaaagc agcattttga gagtaaagta 2731561 gtacgcagga atcataaaac gtaaggaagt tttatatgaa aaaaacatta aaactgcaaa 2731621 ccagactcac catatttgtt tgtatcgttg tattaatcgc attgctcatt acgtttttta 2731681 cagtcggtgc ccaaaccacc aaacgaatta gagatcagga aaaggccact gcgctgcaga 2731741 ctgctgaaat ggtagctgaa gcgccgatga cagccgctgc tttagaaagc ggaaaaaaac 2731801 aaaaggaact gcagagctac acaaagcggg ttcagaaaat taccggcacg gaatttgttg 2731861 tcgtcatgga tatgaacggt atccgcaaaa ctcatcctga cccgagcaaa atcggaaaaa 2731921 aattcagagg cggtgatgag tccgaggtat taaaagggca tgtccatatc agcacagcct 2731981 ctggcacgct cgggaaatcg cagagagcgt tcgtccctgt ctacgcggag aatggaaaac 2732041 aggtcggtgc agtcgcggtc ggcatcaccg taaatgaaat tgatgaagtg atcagccata 2732101 gcttacggcc gctttacttt attatttgcg tcagcatctt cgtcggtgtg atcggagccg 2732161 ttatcgtcgc ccgtacagtg aaaaatatca tgtacggact tgaaccttat gaaattgcga 2732221 ctctgcttga agaacggagc gcgatgctgg aatcgacgaa ggaaggaata ctcgctgtcg 2732281 atgaacatgg caaaattaaa cttgccaacg cggaagcaaa acgcctattc gtcaaaatgg 2732341 gcatcaacac aaatcccatt gatcaggatg tagatgacat cttgccgaaa agccgcttga 2732401 aaaaggtcat tgagacaaaa aaacctcttc aagacagaga cgtccgcatt aacgggctgg 2732461 agcttgtgtt taatgaagtt cctatccagc tgaaaggaca aactgtcgga gcgattgcaa 2732521 cattccgcga caagaccgag gtaaaacatt tagctgaaca gctttccggt gttaaaatgt 2732581 atgcaaacgc actgagagcg cagtctcatg aatttatgaa caaactgcat gtgatattag 2732641 gtctcgtcca gctgaaagag tatgatgatc ttggagatta tattaaagat atagccatac 2732701 agcaaaaatc agaaacaagt gaaattataa atgatgtcaa aagctccgta ctggccggtt 2732761 ttctgcttgg aaagcaaagc tttatacgtg agcagggcgc aaatcttgat attgaatgca 2732821 acggtgtcat cccgaacgcg gcagaccctt ctgtcatcca tgaacttatt acaatcatcg 2732881 gaaatctcat caacaatggc ttagatgccg ttgccgatat gccgaaaaaa caaatcacca 2732941 tgtccatgcg cttccataac agcatacttg atattgaaat taccgatact ggagcaggca 2733001 tgtctgaaga agaccaagcc aaagtatttg aacaaggcta ttcaacaaag ggcaaaaacc 2733061 ggggattcgg cctttatttc acacagcaaa gcatcgaaaa tttaaaaggc caaatgatcc 2733121 tcacaagcga aaagaatgaa ggaacgacat tcagtattcg catcccgtac gaaccgaagg 2733181 aggaaaatca tgattaatgt actaatagtt gaagatgacc ccatggtggg tgaattaaat 2733241 aaacgatact taagccaaat agatggcttt cagctgaaag gcatcgcttc ttcctttcaa 2733301 agcgctctgc atattttagg ggagcaccat attgacctca ttttgcttga tatttatatg 2733361 ccgggaaaaa acgggctgga actgctgacg gaattgagag cccaaaatga agcggttgac 2733421 gtgattgtca tctcagcggc cagcgagctt gacgtgatca agaaaacact tcggtacgga 2733481 gctgttgatt atttaatcaa accgtttgaa tttgaacgat tccaaacggc tctgtctgat 2733541 tacagacgaa aacaaaaggt gtattcaacc catcgcaaca tgagccaaaa agaactggac 2733601 gccgagcttt ttcaaaagaa agaagcaaca gaaaaagtgc agcttcctaa aggcctgaca 2733661 aaaagcacgc tgaagctgat ctggtccagt atccagtcat ttgaaaatga atcttttacg 2733721 acagaagact tggcaaagca cacagaaatc tctcaagtat ccatacgaaa atacttaaag 2733781 tttcttgaag atatacaggt tctgaatgta gaaatggcgt acggaacgat cggaagacct 2733841 gtgtttcagt acaacgtcaa caacagtaac attaacggaa taaagcaata tctataagaa 2733901 aacgcactgc ttgctttgag cagtgcgttt ttctgtcata tctcttgcca agatgcttga 2733961 ttctattgtt gataagttat acaagaataa caaagggctt tcacattttt aagcaaataa 2734021 ttctaaaaat agataatttt taaaaaatta tgcgaaattc tatttatttc ttattagtta 2734081 aatgataaat tatgattggt tagttgatcc cgaaaaacta agtcataagt cttacttcag 2734141 aaaacgatgt cacggttttc cgcccggaac gccttccgca tccttctctt ccccgccttt 2734201 cgaaggaaat actcacacca cgcttattca gggaagaata gaactgtctc agcgcattcc 2734261 atttgttatt atcagaaaat tttatcgatt ctaagaaatt gttcaggaca gcccatcaca 2734321 tgactggccg gatcagcttt gaaccaaatt tttctggggg gttatatctt gaataaacga 2734381 aaaatcggat tggcgatgtc acttgtgatc gcagcaggca ccatattagg agcatgcgga 2734441 aacagcgaaa aaagcagcgg ctcaggcgaa ggcaaaaaca aattcagtgt ggcgatggtt 2734501 actgacgtag gcggagtgga tgacaaatcc ttcaaccaat cagcctggga aggcatccaa 2734561 gcctttggga aagagaatgg gctgaaaaaa ggcaaaaacg gttacgacta tcttcaatcc 2734621 aaatctgatg cagactatac aacgaactta aataaattgg cgcgtgagaa ttttgactta 2734681 atttacggcg tcggctactt aatggaggat tcaatcagcg aaattgctga ccagcgtaaa 2734741 aatacaaact ttgcgattat agatgctgtt gtcgataaag acaacgtcgc aagtattacg 2734801 tttaaagagc aggaaggctc atttctcgtc ggagtggccg cagccctatc aagcaaatca 2734861 ggaaaaatcg gctttgtagg cggcatggaa tcagagttga tcaaaaaatt cgaggtcggc 2734921 ttccgtgccg gcgtgcaagc agttaaccct aaagccgttg tagaagtgaa atacgcaggg 2734981 ggtttcgata aagccgatgt cggtaaagca accgccgaaa gcatgtataa atcaggcgta 2735041 gatgttattt atcactctgc gggcgccact ggcacaggcg tctttactga agcgaaaaac 2735101 ctgaaaaaag aagatccaaa acgcgatgtc tgggtcatcg gtgtcgataa agaccaatac 2735161 gcagaaggcc aggtagaagg aacagatgat aacgtcaccc tcacttccat ggtgaaaaaa 2735221 gtagatacag tcgttgaaga tgtaacgaaa aaagcgagtg acggaaagtt cccgggcggc 2735281 gaaacactta cctacgggct tgatcaagac ggagtcggca tttctccatc taaacaaaat 2735341 ctatcggatg atgtgatcaa agcggtcgat aaatggaaga aaaaaatcat cgacggattg 2735401 gaaatcccgg caactgagaa agagctgaaa accttcaaag ctgaataaga atcgcaggga 2735461 taaggaggtc gagcccttat cccttgtttt tcttttattt tgaaataaag gagcggtcaa 2735521 tcaatggaat atgtcattga aatgctcaat atccgcaagg cgtttccagg tatcgtcgcc 2735581 aatgacaata tcaatcttca agtcaaaaaa ggcgaaatac acgcgttgct cggtgaaaac 2735641 ggagcgggga aatcaacatt gatgaatgtc cttttcgggc tgtatcagcc ggagcggggt 2735701 gaaattcggg tgcgcggcga gaaggtgcac atcaacagcc cgaacaaagc gaatgacctt 2735761 ggaattggaa tggtgcacca gcactttatg cttgttgaca cctttacagt tgctgaaaat 2735821 attattctcg ggaaggagcc aaagaagttt ggcagaattg accggaagcg tgctggccaa 2735881 gaggtgcagg acatttccga tcgatacggc ctgcagatcc atcctgaagc aaaagcagct 2735941 gacatatcag tcggtatgca gcagcgcgca gaaatattaa aaaccctcta ccgcggtgcc 2736001 gacattctga tttttgatga accgacggct gttttgacgc ctcatgaaat taaggaactg 2736061 atgcaaatta tgaagaacct ggtcaaagaa gggaagtcca tcatcttaat cacccataag 2736121 ctgaaagaga ttatggagat ttgtgaccgc gttacggtta tccgtaaagg aaaaggcatc 2736181 aaaacccttg atgtccgtga tacaaaccaa gacgaactcg ccagtctaat ggtcggccgt 2736241 gaggtatcgt tcaaaactga aaagagagct gctcagccgg gagcggaagt gcttgcgatt 2736301 gacggcataa ctgtaaagga tacccgcgga atagagacag tcagagattt gtctctttct 2736361 gtcaaagcgg gagaaatagt cggcatagca ggcgtcgacg gaaacgggca atctgagctg 2736421 atcgaagcgg tgacaggact ccgcaaaaca gattcaggaa caatcacctt aaacggaaaa 2736481 cagatccaaa acctgacgcc aagaaaaatc actgaatccg ggatcgggca tattcctcag 2736541 gatcgccata aacacggtct cgtccttgat tttccaatcg gagagaatat cctgctgcaa 2736601 agctattaca aaaagccgta ttcagcattg ggcgttttac ataaaggcga aatgtacaaa 2736661 aaagcacgca gcctgatcac tgagtacgat gtcagaacgc cggatgaata tacacacgct 2736721 cgggcattgt caggcggaaa ccagcaaaaa gcgattatcg ggcgggaaat agaccgaaat 2736781 cctgatttat taattgccgc ccagccgact cgcggccttg atgtcggagc gattgaattt 2736841 gtccataaaa agctcattga gcagcgtgat gccgggaaag ccgttcttct cctctcgttt 2736901 gagcttgaag aaattatgaa tctcagtgac agaatcgccg ttatttttga aggacgcatt 2736961 atcgccagcg ttaatccgca ggaaaccact gaacaggagc ttggtctctt gatggcagga 2737021 agcacgcaaa aggaagcggg gaaagcaaat ggttaaacga ctctctcatt tactcgtgcc 2737081 gctcatcgca atcatacttg gtcttgcggc cggcgcgttg attatgcttg tgagcggcta 2737141 cagtgtggct agcggatatt cggctttgtg gaatgggata ttcggagaaa tctattatgt 2737201 cggagaaaca atccggcaaa ttacgcctta tattttatcc ggattggctg tcgcctttgc 2737261 attccgaacc ggactcttta atatcggcgt cgagggacag ctgctcgtcg gctggacagc 2737321 agcggtttgg gtcggtacgg cgtttgacgg accggcatat attcacttgc cgctcgcatt 2737381 gattacagcg gcagctgcag gaggattatg ggggtttatt cccggcattt tgaaagcgcg 2737441 attttacgtt catgaagtca ttgtcaccat tatgatgaat tatatcgcgc tgcacatgac 2737501 caattacatc atttcaaacg tcttgacaga tcatcaggac aagacgggga aaattcacga 2737561 atccgcctcc ctccgctctc cttttcttga acagatcacc gattactcac ggctgcattt 2737621 gggaatcatc gttgcccttc tcgcagcagt tatcatgtgg tttatcatca acaaatctac 2737681 aaaaggattt gagctccggg cggtcgggtt taaccagcac gcttcccagt atgccggcat 2737741 gagcgtgcgg aagaatatca tgacctccat gcttatctcc ggcgcttttg caggtcttgc 2737801 cggagccatg gagggcctag ggacattcga atacgcagca gtgaaaggcg catttaccgg 2737861 cgtaggcttt gacggtatcg ctgtcgctct tctcggggga aacacagccg taggcgttgt 2737921 actggcagca tgcctgcttg gcgggctgaa aatcggcgca ttaaatatgc cgattgaatc 2737981 aggcgttcca tcagaggtcg ttgatattgt gattgccatt attattctat ttgtggcttc 2738041 aagctatgcg attcgtttcg tcatgggcaa attgaagaaa aagggggcga actaagtgga 2738101 cattgtgcag attttatcta tcattgtccc tgccacactc gtctatgcgg ccccgcttat 2738161 tttaactgct ctcggcggcg tgttttccga gagatcaggt gtggtgaata tcggcctaga 2738221 aggcctcatg attatcgggg cgttcaccag cgtgttattt aatttatttt ttggtcagga 2738281 attaggtgcc gccgcacctt ggctttcgct ccttgccgcc atggcagcag gcgccctgtt 2738341 ttcactgatt cacgcggcag cggcgatttc gtttcgcgcc gaccagacag tcagcggtgt 2738401 cgccattaac atgctggcgc ttggggcaac tttatttatc gtcaaactga tctacggcaa 2738461 agcgcagaca gacaaaattc cagagccttt ttataagacg aaaatccccg gtttgggcga 2738521 tattcccgtc ttgggaaaga tcttcttttc ggatgtctat tatacgtcta ttcttgcaat 2738581 agcacttgcc tttatttcct ggtttatctt gttcaaaacg ccgttcggcc ttcgtatccg 2738641 ttctgtcggc gagcatccga tggcggccga tacgatggga atcaacgtat ataaaatgcg 2738701 ctacatcggc gtgatgatca gcggattgtt cggcggtctc ggcggcggcg tatatgcctc 2738761 cacaattgcg cttgatttca cgcactctac catctccggg caaggtttta tcgccctggc 2738821 agcgcttgta ttcggaaaat ggcatccgat cggagcactg ggggccgccc tgtttttcgg 2738881 attcgcccaa agcttaagca tcattggatc gctgctccct ctttttaaag acataccaaa 2738941 tgtgtatatg ctgatggctc cttatatctt aacgattctc gctttaaccg gctttatcgg 2739001 gcgggcagat gcgccaaaag ccaatggcgt gccttatatt aaaggaaaaa gataaacatt 2739061 ctcccctggg aagacgattc tcagggattt ttttctaatc caaaagaccc ccttaattta 2739121 attgtttatt agttttttaa cttaaaaaaa tatgaagtgt taacgctttc ttgtagactg 2739181 taacaaacaa tacatggggg tgtatgacat gggagcaatt ccaaaaacgg ggacaatttc 2739241 acctgagcaa aaagactcac aggagaaaaa cctgtttcaa aaaatttggt cttgggaaat 2739301 cggtgtgatt cctttgccat tatacacagt attagctgtt attattattc ttgcagcata 2739361 ttacaatgag ctgccggcaa atatgcttgg cgggtttgcc atcattatga ttcttggtgt 2739421 gtttctcgga gacataggcc aacgcatacc gatattgaag gatattggcg gccctgctat 2739481 tttatctttg tttgttcctt catttttagt cttttacaat gtactgaatt caacatcttt 2739541 agacgctgta accaacttga tgaaaacgtc taacttcctt tatttctata tcgcttgcct 2739601 tgttgtggga agtatcctcg gtatgaacag aattgtttta atacaggggt ttatcagaat 2739661 gttcgttcca ctggttgcag gaacgatcgc ggccgttgca gccggcatcc ttgtcggatt 2739721 tatttttggc tatagtgcct atgattcctt tttctttgtt gttgtcccga ttattgccgg 2739781 gggaataggt gaagggattt tgccgctttc aatcgcctat tcacaaatac tgggctcatc 2739841 cgccgatgta tttgtgtctc agctggtgcc agccgcaatt ataggaaacg tttttgctat 2739901 catatgtgca gccttaatga aaaagcttgg cgacaagcgt ccagatctaa atgggaacgg 2739961 acgtctcgta aaatctaaaa aagcaaatga gattttcaat caaaaagaag ccgaagcaaa 2740021 aattgatttt aaactaatgg gagcaggagt tctgctcgcg tgtacattct ttatttttgg 2740081 cgggttattg gagaaattca tcttcatccc gggcgcgatc ttaatgatta tttcagctgc 2740141 ggctgtcaag tatgcaaata ttcttccgaa aaaaatggaa gaaggcgctt accagcttta 2740201 taagtttatt tcttcaagct ttacatggcc gctgatggtc ggtctcggca tcctctttat 2740261 tccgttggat gacgtagcgt ctgtgatttc tataccgttt gtcatcatct gtatttcagt 2740321 tgttatcgcg atgattggtt ctggatattt cgtaggcaag ctgatgaaca tgtatccggt 2740381 tgaatccgca atcgttacct gctgccacag cggtctcggc ggaacgggtg atgttgccat 2740441 tttatcggca tcaggaagaa tgggccttat gccgtttgcc caaatttcaa cccgtctcgg 2740501 cggtgcaggc acagttattt gcgcgacagt gctgcttcgt tttttcactt cataaacaga 2740561 aagagttccg ttttatgcgg aactcttttt ttatttattc acaatccgaa tatactctcg 2740621 gggaccaaac ggcagatcct ttgattccgt ctcactcatt ctggctgaca ggtggtgctc 2740681 cagtaaatac agctcccact catcacaagc cgccacaccg ctgcgcccgt catattgatt 2740741 caacatgaat gcccctgcaa atactgagca gaataaacct gagcacatca cgacttttgt 2740801 tttcacatga ccagctcctt tccttcagct tgatcaggat tgattttaaa tatacaaata 2740861 acctcttttt tgttagactt attttgaggt caaaagaact cataaaaatc cattacagca 2740921 gttcgaagcg tggcagcttg cagaaaagtg cgatataatt tggactaggt cgtttgaccg 2740981 tatattttat acatagcgca tttttcaatt gagaacgaga aaaggaggtc ttatctttgc 2741041 agctcttaca tcttgctatt ttatcgcctt ttttatttgc ttttatcatt cccttcttgg 2741101 caaaatacgc aaaaagagtg catacgggct ggtttgtgtt gatcctgccc gtcttgctgt 2741161 ttatatactt tctcccaatg atcaggatga cgcaatctgg agaaacactt cgatcggtat 2741221 tagagtggat tccgtcactc ggcattaact ttaccgttta tatagacggc ctcgggttat 2741281 tattcgcttt actgatcaca ggcattggct ctttggtcac tctttacagc attttttatt 2741341 tatcgaaaga aaaagaacag cttgggccct tttatgtcta cttattgatg ttcatgggcg 2741401 ccatgctcgg cgtcgttcta gtagacaatg tcatggttct ctacatgttc tgggagctta 2741461 caagcctttc atcctttttg ctgatcggct attggtataa gcgggaaaag tcgcgctatg 2741521 gcgcagccaa atcacttttg attacggtca gcggcgggct gtgcatgctc ggcggattta 2741581 ttctccttta tttgataacg gattccttca gtattcgaga gatggttcac caggttcaat 2741641 taattgccgg ccacgaattg tttatcccgg ctatgattct cattttatta ggggctttta 2741701 cgaaatcggc gcaatttcct ttttacatct ggctccctga cgcgatggaa gctccgacgc 2741761 ctgtcagcgc ttatctccat tcagctacta tggtaaaagc cggcatttat gtgattgcga 2741821 gattcagtcc tattttcgcc ttttcagctc agtggttttg gatcgtgtcc ctcgtcggcc 2741881 tctttacgat ggtttggggt tcattccatg ccgtgaaaca aactgattta aaatcgattt 2741941 tggcgttttc aaccgtcagc cagctcggca tgatcatctc catgctcgga gtcagtgctg 2742001 cggcccttca ttacggacat acagaatatt atacagttgc cgctatggct gccattttcc 2742061 atttgatcaa ccacgcaacc tttaaaggaa gcttgtttat ggcagtcggg attatcgatc 2742121 acgaaacagg cacacgggat atccggaagc taggcggcct gatggcgatt atgccgatta 2742181 cttttaccat ttccttaatc gggacatttt caatggccgg cctaccgccg tttaacggat 2742241 ttttgagtaa agaaatgttt ttcacaagca tgcttcgcgt gacacatttt gacctgttca 2742301 acgtgcagac atggggcgtt ctgttccctc ttttcgcctg gatcggaagt gtatttacgt 2742361 ttatctacag catgaaattg ctgtttaaaa cattcagagg aaattaccag cctgaacagc 2742421 ttgaaaaaca ggctcacgaa gcgcctgtcg gtatgctcgt tccaccggtc attcttgtcg 2742481 ctttggctgt cagtctcttc tttttcccga atatattgtc gtacagcctg atagagcctg 2742541 cgatgaactc aatctatccg acactgcttg acggccatga gaaattccac gttcacattt 2742601 cacagtggca tggggttaca acggaattgc tcatgactgc gggtattgtt gtgatcggaa 2742661 caattggtta tttgtcgctg aataagtgga aaggaatcta taaactgttt ccttcgaaac 2742721 tcacactcaa ccggttatac gataagcttt tgactatgat ggagaaaggc tcttaccggg 2742781 tcacaaaaca atatatgacc gggtttttaa gagattattt gctgtatatc ttcgctggtt 2742841 tcatcattct gataggcgga gcttttgcca ttaaaggcgg attttcattt aaaacggaag 2742901 gcatggctaa aatcggtgta tacgaaatca ttttgacgct tgtcatgatc agcgccacag 2742961 tggcgactgt ttttgctagg tcaagactga cggcgatcat tgcactcggt gttgtcggtt 2743021 atacgcttgc attgtttttt gtcattttca gagcgccgga cttggcattg actcagctcg 2743081 tcattgaaac gatttctgtg gcactgtttc tgctttgctt ctaccatttg ccgaaactga 2743141 ggctgaaaac aaaaacgaga acgttccgga tgacgaattt tatcatttct ttaggcgtcg 2743201 gtgttatcgt tacactgctc ggcatcgcat cctcaagcca gcggacaaaa gacagcattg 2743261 cgtccttctt tgtcaaacac agccacgatc tcggcggagg ggataatgtc gtcaatgtca 2743321 ttctcgttga tttcagggga tttgatacaa tgtttgaaat tacggtatta acgatagccg 2743381 ctctcggcat ttacagcatg attaaaacaa aagtaaaaga ggaggggaaa agcggtgaat 2743441 gaacaaaaaa caaatgactt gattcttcaa accgcgacaa agcttgtatc ctttatcatt 2743501 ttgcttttct ctttctattt atttttatca gggcataacg cgcccggagg aggctttgtc 2743561 ggcggactga tcacgtcctc ttccatcgtt ctcttgctct tggcatatga tttaaaaacc 2743621 gtgcgttccc ttttgcctgt caatttcatt tatgtcgcgg gagccggcct tctgctcgct 2743681 gtattaacag gcgttggctc ctttgtcttc ggggctcctt ttttaaccca cacattcgga 2743741 tactttcagc tgccgatcct tgggaaaacg gagctcgcca cagcgacgat atttgattta 2743801 ggcgtttatc ttgttgtcgt aggcataacg atgaccatta ttcaaacgat tggagaggaa 2743861 gaataatgga aatcttaatg gctgtattag ccggtattat ttttatggct gctacgtatt 2743921 tgctgctgtc taaaagcctg cttcgcgtca ttatcggaac agcactgtta agccatggcg 2743981 ttcatttaat gcttttgact atgggaggat taaagaaagg cgccgctccg attttgagcg 2744041 agcatgccaa atcatttgtc gatccgcttc cgcaagccct gattttgacc gcaattgtca 2744101 tttcttttgg cgttacgtca ttcatcctcg tcatggcctt tcgcgcttat caggaattga 2744161 aatcggacga tatggatcaa atgaggggaa atgatcaaca tgaataattt tgttattttg 2744221 ccaatcctga tcccgctttt gtcggctatt cttctgattt tcatgacgaa gaatcttatg 2744281 ctcatgagaa tcttcagcac ggcggcatcg gccatcggga ttgtgattag cggcatactt 2744341 gtacagactg tcttcacaaa aggcatccag acactcagcc taggcggatg gaaagcgccg 2744401 tacggcattg tgcttgccgc agaccaattc gccagccttc tcgttctcac aacagcgatc 2744461 atcggtttat tggttgggct ttattccttc cgttctgtcg gtgaaaaacg ggagcgctcc 2744521 ttttactact ccggcgttca gttcttgctt gccggcgtca gcggagcgtt tttaacaggc 2744581 gatttattta atatgtacgt attttttgag cttctgctta ttgcttccta tatgctgatt 2744641 gtattaggcg gcacaaaaat tcagctgcgg gaatccctta aatatattgt gtttaatatt 2744701 gtatcgtctg ccctgtttgt cataggggtc ggctttttat acgctgtaac cggtacgtta 2744761 aacatggcgg atcttagcgt gaaaatcagc gaatcaggac aaaccgggct gatcactgtg 2744821 attggtgtcc tgctgctttt ggtatttggc atgaagggcg gaatcttccc cctctacttt 2744881 tggcttccag gctcttatta cgcgccaccg gcggcaatct ccgcgttgtt cggcgctttg 2744941 ctgacaaaag tcgggttata tgcgattacg agggttttca cattgatttt tattcacgat 2745001 acagccttta cccatcagtt gatgatttgg ctggcggcgc tgactgtgat ttttggtgtg 2745061 atcggttcac tcgcttattc gaatgtcatg aaaattgtga tctataacat tattaccgct 2745121 gtcggcgtga ttttgttcgg tgtggcagta cacacccccg catccattca gggcgcgatc 2745181 tactatctga ttcacgatat gctgattaag ggcgctttgt tcatgctggc aggtacgctg 2745241 atcgcattga ctggaaccgc gagcctgcat aaaatgggcg ggctgatcaa acgctatcct 2745301 gttcttggat ggatgttttt catttccgct atttctcttg caggcattcc gccactgagc 2745361 ggatttgtcg gcaaatttaa aattgcagag ggcggcttcg cagaaggtga atttacgata 2745421 tccatgctga ttctgctttc gagtctgctt gtactgtact ctgtgctgag gatctttata 2745481 catgcgtttt ggggcgaaga aaaagaaacg ccaaaaccaa atcatcgaac agctaaagga 2745541 cttctttatc cggcagctat ttttctcttg ctgtcccttc tcttcggatt gggtacagaa 2745601 tgggtgtcgc cttacgttga tcaagcggcc gagacgctgc tgaatccgga aaaatatatc 2745661 gaagctgttc tgaaggagta gatcgcatgg catttcaaat tttattaaat gtgtttctcg 2745721 ctttttgctg gatgttctta agcaacagtc caagcgccgc aggattcatt acaggctata 2745781 ttctgggaat gctctctctc tttttcttcc ggcgcttttt cactcgccag ttttatctat 2745841 ggaaattgat ttctattatc aagctctgtt tcatttttat aaaggaactg taccttgcca 2745901 atgtcagtgt gatgaaatca gtcttatctc caaaactgaa tatcagaccg ggtatttttg 2745961 cttttaaaac tgaactgacg aaggactggg aaatcaccat gctttctctg ctcattacat 2746021 taacgccggg aaccttggtg atggatattt cagatgacag aacaatactt tatattcatg 2746081 caatggatat cgaggatgcg gaaaaagcga tttttgacat tcgggagtca tttgaaaaag 2746141 ccatacagga ggtgagccgg tgatgtttac gctgatcctg caaatcgcgc tcggcattat 2746201 ggcagtgtct acctttttgt atgtcattcg tgtcattaaa ggtccgactg tgcctgaccg 2746261 ggtcgtggct ctggatgcaa tcggcatcaa tctgatcgca atcacggcgc ttgtctccat 2746321 tttgctgaaa acaagtgcgt ttttggatat tattttgttg ctggggattt tatcgtttat 2746381 cggaacgatc gcattttcca agttcctgga gaaaggagag attatcgaaa atgatcgaaa 2746441 ccgctaaggt cgttgtggct gtattcattt tgctgggtgc tcttatatgc ctcattgctt 2746501 catttggcgt acttcgcctt cccgatgtgt ttacacgcgc tcatgctgct tctaaaggct 2746561 caacattagg tgtcaatatg attctgctcg gtgtcttctt ctatttgtgg tttgtgacgg 2746621 gggagctctc cgctaaaatc ctgcttggga ttctctttat ctttattacg tcgcctatcg 2746681 gcgggcactt gatctgccgt gctgcgtata actccggcgt caagcttgat gagagaagtg 2746741 tgcaagatga ctataacgga atcagaaact ttgtgattaa acgaaaagag gattcttatt 2746801 tataaaaata agcagccgga caggcagagt tccggctgtt tttttatttc ttgatgacag 2746861 ccagcgtgca tctggatata cagatcagcc tctcttgctc gtcatatatg tgaatatgat 2746921 agacaatcgt cgttctgcct atatgaacgg gctcggctat cgcctttacc gttccttcct 2746981 ttacagattt taaatggttg gcgttaatct ccaaaccaac acaagcttgc gttgtatgat 2747041 caatcaggtt ctgtgcacct gcgctcgccg cggtttccgc cagggccact gaagcgcctc 2747101 catgcaaata tccgaacggc tgtaccgtcc gatgatccac cggcatgacc gcaacgcatc 2747161 gttccgctgt gttttcaaca atctcaatac caagcgcttc aagcaatgtg tgcttcatat 2747221 ccatctctac accccccaac atttaaagta caccgtctga tttcgcaatc aaaaccgctt 2747281 ccgtccgtga accgacattc agcttattga aaatcgatgt caagctgtat tcaatggacc 2747341 gcttgcttaa atgaagggca tctgcgattt cttggtttgt aaatcccttt tcaacttctt 2747401 gaagaatcag gcattctcta ggtgtgagca catcttgttc tttttgagag gaaggagccg 2747461 gctttgtttt ttgctgagtc atcagctgtt taaagtaagc aaaatcgact aaaatttctc 2747521 cgttgagtac gtggtatatg tattgggtga tcttttcttt agattccgtt ttgctgatgg 2747581 caccgtgcag acccgcacga atcgcttcct cgaaataatc ctcgacctca taaccggtat 2747641 acacgataat tttacaatga ggattctctt gtaaaatctg tttagaaagc tccatcccat 2747701 tgacctcgcc gcctagattc agatccatta aaatgagatc atatgacgag aaatcatgct 2747761 gcttgataaa ctgttcgctc ggttcaggac tgagacaatc aacagacaaa ttcgaatccg 2747821 tttccaaaat tgtcttggtg ccttccatga cagccggatg gtcatcaatc actagtatct 2747881 ttttcatgtt ttcctccctt ttactcactc ttttccattt tataaaaaag acttggcctg 2747941 tgccaagtcg tttccgttat aaatccatta caattcgatt tcaatatcag ccttaaagcc 2748001 ctttccttca cttgtttcaa tccgaaggcg cccatctaaa gccctgactc tctccttaat 2748061 gccagaaagc cccatgctca tggaatgctc agtatttttt tcttgatcaa acccaacgcc 2748121 atcgtcctca taatgaagaa cgattttgtt ttgaatactg atgagcataa tcagcacatc 2748181 cgtcgcctga gagtgcttga ccgcattaga cagaaactct tgaatgatcc ggtacaaatt 2748241 cagctgcgaa tccagatcaa gggaagccgt aaatctcccg gtatttaaac ggatatgaaa 2748301 cggaacccgc tcctgctgct gcgccaccag cttcgacagc gccttcacca atccaagatc 2748361 atacagaagc tgcggccgca gctcatgaca cgtctccctc gtcatcgaaa tcacatcaga 2748421 catctgctca ttcatctgta caagcttgtc ctgcacctct tcacggcacg gattatcatc 2748481 cttcttgaaa tcacccaaaa acagctcaca ctggcgtttt aaggaaatca aatcctgaag 2748541 aaccgaatcg tggagatcgc gggcgagtcc tgaacgctgt ttttcttcga ttgcaaacat 2748601 tagctttttc agccagatgg ggttggttcc ctcttgtttt aagtccttca aatgttccat 2748661 gagctcctca atatgcagga cattttccat ggacacactt gtataaaaag acagtgtttt 2748721 cagccacgat atttcatcac gtgttagccg gggagtgtta atattagata aacaaagcag 2748781 aacataagaa ctaccgcctc gttcaccaac tttcataaga aagccttgat tgacttctat 2748841 aattttccca atttctgaag ttacgttttc aaattcctct tgataaaaat tccagtccgg 2748901 tccaacttca tgcttatcta aaaatatcac tttgtgatca ggagtaacct caaaggtata 2748961 agctttgctt acaagcaaaa catccagtat agtatttttc agttctttaa aaacttgttg 2749021 aagagaagtt acacccctca ttagctgagt atatttaaaa atactgtcct gatagttgaa 2749081 tttttcggag aaacgtttta accgaaattt aaaatccatg acctctttaa aataaaagac 2749141 agcgaacatg acaacgaaaa aaaatacagt ttgacgcaca gggttcatct ggatgtccat 2749201 tacatcaaac agaactaatg caccaactat tagaagagtt ggtatcatgg caagtagagc 2749261 atagtatctc attcttccta agataaactc tatatcaaac atcttattgg ctacaaattg 2749321 gtatactaac ccgaacggaa ttagtactag taatgacgcc gaagctaatg ccgggaaaat 2749381 ataattacct gtaaatatta ttggaagaac aaaaaatatc aaaaaaggcg caaatgaaag 2749441 agtgtttgtt aaaattagta atttaagaat aaacgaatgc tcagcatatt tatatttatt 2749501 aagatgtaag tatatcgctg aaaaagaaaa tagagtcaaa gttgcaaaag aaaccaaatt 2749561 aagagttgct aaaaaatcaa tatctacttg taaatagtct tgaaaaaact caataccaag 2749621 attaaatatt ggtatgatat aaagaaaaga aattctattc aaaaaagttt tacctatttc 2749681 tccaaggtat ctttgtataa attgaagata aagaatagga gaagatataa aagtaaacaa 2749741 gttaatatac cgattgatta tatgtcctct aaatggtccg cctgcactta tatatgctat 2749801 cgaaatgtct aataacaata gaataagaat ataggcagca aatgatctcc tttttttatt 2749861 tactttaagt atataaaaaa tacatattat gcttaaaaaa taaaaaaaca aaggaagtac 2749921 gaacagaaaa aaactataag gtctatttag agtaactaaa tcaaaatctt tgagatgaat 2749981 cttttttcca cttctcaaaa tatccagact gttaatatga ctcaaatatc cccatttcaa 2750041 atgtttgtct gaaggttttt ctttattaat ttttaatatg atgtctccct gtctcagacc 2750101 aacaaattgt ccatatgaag attccgatat ttcttctatc ataaattgac ttttatcatt 2750161 tttatgaatc ttagtcccaa taataattcc attcatactg atataagttg tatagcttat 2750221 ataaaggata ctcaaaacaa ttacagctat tgtgaatttt tttattaagt tcttcaatat 2750281 taatccacct attaatcacc ccattgacgg gttattggat cagccagata ataatcatta 2750341 taagctttaa ttattgtttc agtttcttgc acatcaaaac ctataaggca ggcttcttta 2750401 tttttcaatt tttttaaagc ctcaggataa tttaaaaagt agttaattag gtcttgcatc 2750461 ttgtatcccc ctttgtataa cttaataagc attcctttat tagctctttt tttctttatc 2750521 taaatttaat tgttctatag cagaaataca tttctgttta tatatttcca ataataccga 2750581 aatgtattga gtaactcccg ctttaattaa tttttcttgg aatttctctt tatcaagtaa 2750641 cgatttataa tataagtctt tatgtgaaat taagtataat aaatcttccg aagcatcatt 2750701 aaaaaggcgc ttaagatata agtaaatcag tgtatgtttg tttttttcaa tatcactgcg 2750761 atttccggat aaaagaacat aataatctcc agaaatttga gctataatcc ctttatagta 2750821 ggaatatctt tcaactgttt cattatattc tcctgtagcc aataaaacac ctgctacatt 2750881 tgctagtgca atcagacttc cacattttaa tctaattact tctaaacttt catcttctgt 2750941 tttagattta ttagtgatat cgtcatgttg accttgcatg gcctcgttta cgtattttaa 2751001 aacatattta aaaattagag gattgttatt taatgaataa atactcgtta atcctactgt 2751061 atacaaggaa agtgctgcat ttaacgactc cgagcgatta attttcatcc ataatgcatg 2751121 gtgattatct tcatcttcaa gatcatccat aatatctgat gaaagaataa gaatttctat 2751181 tcccgcgcca agccttgttg caacatctaa attctcccct ccaaaaacaa cataatgtaa 2751241 gattgtggat tcagcaaagg agaatgtttc tttagaatca ataaatgagt aaagaagttg 2751301 tgacaaatcc tcgttaaata tgttttgctc cacaatctcc ttcattttct ccttgatccg 2751361 gacagaatct aaacatatct gctcaataac gacttccccc ctcccattcc attttactaa 2751421 atgggacatt taaaggacag caggtttttc gttttttaac aatcatataa tactttatcc 2751481 atttattgta tcggtagaac gaaaaaaaag acttgtttcc aagtcttttt cacgaaattt 2751541 tcattgcata attgtattta tcgagttgat caatgctttt gttaatgttt cgtaatgaat 2751601 ctgtcgtttc tttaatatca agttcgagtc ggaataacaa ttgttttact tcttcaagtt 2751661 tcttttccat cgtttccaca ctcctttttt tgaaagatca atgaattgtg tatggtgaac 2751721 gagtcctagg tatttgatct gttactaata gtgtgtctgc tttcggctca tttttcaccg 2751781 aaaagtatgc aaaaaagtcc tgcgtgacac cgcaaatctc aataggtcct tatactcaaa 2751841 ggaatcacaa caagaacggg actatctttc tatgcgaaag agcgtttata tgtgctgaaa 2751901 ttgagaaaga ttcttaatct ccttgatttt aacgggtttc gcattttcac taagcaagac 2751961 tatagtcctt cataccgtat tttcaaaatt gaatatgcga ttcttggcgt ttcctgaccg 2752021 acaaacaccg aaaaagaccg caacgctaaa gttgtggcct tttcgctttg tcatattcgg 2752081 caattaggga tctatacata tagaaacatc cttttttgcg aggtgctccc atgagatatc 2752141 gttatccctg gttttacgtg tatccgtatg aggtacgccg tccgcccgct cctgccaaca 2752201 atattgatac ctttatccgt tcagcgaagc aggccgcagg gatatttgcg gatgcccagc 2752261 tcgttctcag ccgcattgcg ggctcgcggg agctttcgcg ccgcattctg accgcagccg 2752321 aacagtctga taaacaaact ataaggcgcc tgatcaaaca aatgggcgtc cggcatgaag 2752381 tggatacggt ctttaatccc gacggcatct atatcagcct tatcggaacg caaagccgaa 2752441 tgattcttgc tttgcggtgg tcagaggacc gcaatcattt tgcgtccata agattatgac 2752501 accattccag agcctctaaa taacattcat acgcttcttc tttgtccagt tgattgccta 2752561 attctgagca agtgtcccag ttgttgcttt caattaattt cacaagctca agcatttggt 2752621 agtagtcgtt ttgatggcct aataatgctt gcccgacttc atcttttaaa ggcaattctt 2752681 gaacaatttc ctctatttct ctatgcagga gggtgtctat gagagaaaac attccgatca 2752741 gcatataaga agcaggctgc ggccgggatg tctttctcgc cagcagttcg caaagctttg 2752801 ctcttatcag agaaatctta atgatttcgt gcttgctgga atgccctttc ctgcttaaat 2752861 ccttaaagga aagaatatat atccaccgtt tgatttcatt aaatcccagc agcataatgg 2752921 cctgttgaat gctttcaatt ttctggctca aacggctgtg ggatgagttt aaaaatttta 2752981 aaatttgata ggacagtgat aaatcccgct ctatgtactc tgtcacacgc tttatgttag 2753041 gctgctcttt actcagttcg ttaagcagtt catagtaaga atagaaatga gtcgataggt 2753101 catgcccgct gatgatgcgc ggctcgctga aaaagtagcc ttggaataat tgaaagccgt 2753161 cttggaccgc ctgtttatat tcttttcggg tctctacttt ttccgctaaa aaaatcaggc 2753221 cgcggcagcc gtaggtttgc aaaattgttc tgcgttccat tcgtgttgtt ttgagaaaat 2753281 caattttcaa tatatcaata tagctcatga gtttttccag taagtcctca tcttgcggat 2753341 ttattgcata aaaatcatca agcgccagca tataccccat ttttttcaat tctttgcatc 2753401 tagaaatgag ggccggcgtg atcggtatat cttcaaggat ttcaatgaca agctgtttcg 2753461 gattgaagga ggtgggaaga ttcgaaaaca tcaggctttc cgtaaaatta acaaaacagc 2753521 gtttcccttc cgtcagcttc tcaattccga tgtttaaaaa gctgttgatc accaaatctg 2753581 ttgttgcctg atcgccgtct ttagcgctat acacgttctc ttcgctttct ctatacagca 2753641 gttcataagc aacaacctgt tcttttctat taaaaatagg ctgtcttgca acaaacaccc 2753701 tcattgattt atccccctta caatacgcgc ggctttcacc cctaagtata tcaaataatt 2753761 tgacgaaaat tgtctaaaca tgaaaaataa tatatacata aagaaaactg gcccttcgcg 2753821 aatgaaaggc cagtttttct ttattcttcc tcaagctctt cttcaattct gcttttcact 2753881 tcgtggatcc gctgcatttt attgctccag cagtcctcgc ttaaatcaac cgggtattcc 2753941 tccggcttgc tgattctctt atattcctcc caaagcaggc tgaggttatc ctgcacatac 2754001 tgctgtatgt ctgaaatctc agggttttgg tagcaaagaa tacccttctc aaaaatcagt 2754061 tcatgaagat ccttcgcata aaaattcgtg acaaatttgc tgatgaatgt atgaaccggg 2754121 tggaacattc tgagccgctt ctgatcattc acctgctcat cataaagcgc aatatagtcg 2754181 ccttcagaat gatggttgga ctgattaata atgcggtaga ctttctttct gcccggtgtc 2754241 gtcacttttt caggattgga cgaaattttg atcgtgtcga ccattttccc gtcttcttca 2754301 atggcaacga gtttataaac tgcgccgaga gccggctggt cataggcagt gatcagcttc 2754361 gtaccgacac cccagacatc aatgcgcgct ccctgagcct ttaaattcat aatggtgtgc 2754421 tcatccaaat cgcttgaagc aatcaccttc gcatctgtaa atcctgcttc atcaagcatt 2754481 ttccgggctt tttttgacag gtacgccaaa tcgccgctgt ccagacggat gccaatgaaa 2754541 ttaatgcggt cgccgaattc cttggcaacc ctaatcgcgt tcggcatgcc tgaacgaagc 2754601 gtgtcatacg tgtcaactaa gaagacgcaa tccttatgtg tttccgcgta ttttttgaaa 2754661 gctgtatatt catcgcggta agcctgcaca agcgcatgcg catgtgtgcc ggaaaccggg 2754721 atattaaagc gctttccggc tcttacattg cttgtcgcgc taaagccgcc gattaaggct 2754781 gctctcgctc cccacatggc cgcatccatt tcgtgcgccc gtcttgttcc gaattcaagc 2754841 gcaacttcat caccgatgac gcctttaatc cgggcagcct ttgttgcgat taatgtttga 2754901 tagttcacaa tgttgagcaa agctgtttca atcagctgcg cttctaccag gggtgcctcc 2754961 accctcataa tcggctcatt gttaaaaacg agttctcctt ctttcatgga gtaaagtgaa 2755021 cctgtaaaag ataagccgcg caaatattca ataaaatctt catgataccc gagttcatcc 2755081 tgtaaataac tcaaatcgct atccgtaaac ttgaaatttt ccaagtattc aatggctttt 2755141 tccaagcccg caaatacggc atagccattt tcaaacggaa gccttctgaa aaacagctca 2755201 aaaatcgctt tcttttcatg aatgccgtct ctccagtacg tttccgccat attgatctga 2755261 taaaggtctg tatgtaatga caggctgtca tctttaaatc cgtactctaa cactgttttt 2755321 ccccttcctt actctgccac ttgcgctccg atgctgtttg caaaatggga aagagcccat 2755381 gcgtgcccct cctgattaaa gctggcaaca gcttgtttat gcacaacaat ccgaaaacct 2755441 ttgttgtatg cgtcaacagc tgtatgcaac acacaaatat ctgtgcagac accggcaaga 2755501 tgcagttcgc caatctgccg ctctctgagt ttgagctcta aatcagttcc cgcaaaagca 2755561 gaatatctcg ttttttccat gtagtaaaca ttaggttcat gttcatgttt ctgatataga 2755621 ggcaaaagct ttccgtacag atcttttcct tccgtgcctt ttatattatg cggaggaaaa 2755681 agacgggttt cagggtgata ttgatcccct tcatcatgag aatctactgc taatacgacg 2755741 taatcaccgt ttgtgatgaa ttctttagtt aaattgacga tcgcctcttc aatcattctg 2755801 ccgggctccc cgcaggtcaa ttttccgtca ctcgccacaa aatcattcgt ataatcaata 2755861 caaataagtg cttttttcat agccggcctc cccgccatca gtatgagaac attatatctt 2755921 atctccagtt gtaagtgaat tgccatgaac aaaaagacaa acggtccgtt tgtctcttac 2755981 gatttcagta ctgaccgatt ataaatgtcg tcctgaatat atatcaattc acgattcaca 2756041 gcgatatcag ccgcaatgac gatgcctaag ggcgtatgaa actggagatc agatacaatc 2756101 ttgaaaggca ctccgtaccg gctcgccatt tggatataag aagagtaaga ctgatactga 2756161 agctctccat taatcaaaag ggtgacgtta tggctgtttt tcagctcgtg ctctgcctct 2756221 ttatacggtt tgcttctaag cacctgtcct ttcgtcagtg ccaaaacgac tctttctctt 2756281 aaagagccta aaaacaaatg gcgctcgtca ggctttgtct ccaaaggccc atacattcct 2756341 tgctgcaaat agagatccat tttatcttca ctcaaaagcc tgtcctcccg tcttgtttgt 2756401 cttcattatc acctgatcag gcaggagcta aactttcaag cgccgtttac atttctgtta 2756461 cccaatgaat gatttttttg gccagctcac cagcaggggt ttcctctgta tgccggcgca 2756521 acgacgcttc cagccgttca ggcagagttg ctttatcttc ttcataggaa atgatcgtgc 2756581 tccactccag ctgcggtacc gctacaagcg tgcgcagttc ttttctgttt tcatgcagat 2756641 acacgtccgt gatcattccg gtttgcgtat tgatatttgc ttttctgatt ttcataacat 2756701 gacctctcta ttcaaagact acccatatta tacaataaaa aagcaacagc ctcttgtgaa 2756761 aaggctgtta cccgttaaac gaaactgttt catcagtgat atcggcatct ttgaagagag 2756821 ttttactcgt ttggttgtta atcttcacaa aatcaccaag ctgaaatgtg cctgaccccg 2756881 cccctgaatg agcgacgctt ttgggcgaaa tcgcaaatac gtctccaaag cttgccgcgg 2756941 cattatccgt aactgacatg atataaatcg gccccacaat tgcaggcatt tccccacctc 2757001 cgcattgatt tacagcatca tatgcaagga gccgataatg gtgcccgcct attcagctgg 2757061 ctttgcgttt tcctcgagtc gtgaccgctg gcgcagcttg atcaagcgga caatattcag 2757121 gaagaacgcc ttcactaccg cataaaccgg caccgctaaa atcatgccga gaattccgcc 2757181 gaagcttccc gctccgatta atagcaaaat aatcgtaagc ggatgggtat tcagccgctt 2757241 tccgatcaca agaggagaca gcaggtttcc gtccagctgc tgaacgatga cgaccacaat 2757301 aatcgcaaac agcgctttgg ccggcgagtc cataaaaccg acaatgacag ccggcgcggc 2757361 accgagaaaa ggcccgacat agggaatgat attggtaatc gccatgacaa tcccaagaat 2757421 cagggcatac ggcagtccgg caattaaata gccgataaaa cacgctgttc cgacaaaaag 2757481 acagattaac agctgcccct ggaaatatgc cgcaagcgta tcggataaat ctttaaaaat 2757541 ctttaagcct tctgtccgat aagaagccgg tagaattttt actgccaaat gcggaaagcg 2757601 gtgtccgtct ttcagcatgt aaaaaaggat aaatggaaca gtaataataa caagcgtgat 2757661 gtttgtcacg acaccaaaca ccgcagataa actggacgtg atattttgcg gcaggttttg 2757721 gagaaaactt gtcaatgact gttcaatttt tgatatcgat acataatcct ggttcatcat 2757781 ccaggtaaac cattgagaat gggacaaatc ctttgtcagc gcctgaatct gttttatata 2757841 atcaggaagg ttgttaaaca gccctgtcac ctgtgcggtg atgataggtc cgactgacgc 2757901 tgaaataaag gcaagcaaac cgataaacag taaatagatc aatagaatgg ataatgtccg 2757961 cggaattttt ttctcaagca ggcggacgac cggattaaat atgaaataca aaattcccgc 2758021 aattagcatc gggaaaaaca atgtcgagat aaaaacaata aacggctgaa atacaaatga 2758081 aacttttgtt gctacaaaaa taatcagcaa aacaaataaa atctgcaatg tccaaaaatg 2758141 gacttttgat ttcaacaagc tttgttcctc ctagtttttc tttgtctgtc agataaaaga 2758201 acttataccc catcattgta acaaaaatga actcatatca gaactcttaa tataatgaaa 2758261 ggagtgttgg tgatgaaggc cgtgacatac gatacagatt cagaactggc ttatatctat 2758321 gttcttcctc cgaaaaagaa caggaatgta cggactgagg agctcagagt caatgattgt 2758381 ctcctgctgg atatcagcca agatggcaaa atcgccggat tcgaatgttt tggtgaggca 2758441 gcacacctct gtgccccatt tgccgggaaa tcccggctgt atgtaaaaga ttcagacggt 2758501 tatcattttc gggtctgcca gcatgcttca gtccgttcct gctatacggt gtaccgtgtc 2758561 actttctgtt tttcagatgg tgactatcag gaatttgccg gctttgacct tgatggaaca 2758621 atgtatcata gtgcgttttt acagcgctta actgaaaaat aggacgtcct gttgtacgcc 2758681 tatttttcat gcgcaagcac tgttagaccc gctcactgta atctggggtg acggaaatca 2758741 tgtgctggat tctgatcaaa caaacagaat ttcgggctcc ttcaattgtg atatggtcag 2758801 gttttacatc gatcagtctg cctctgaccg tatctcgtac tgtctgtata acgaaccttg 2758861 agccgatgag ctttttaatg gtctgataga cataaggatc gactaaagag accagttgcg 2758921 gactaccttg gttgaccata cttttatccc ctttgtgtgt tttatctcag cttatgccgc 2758981 gcttatggat aatgacacag gcttacctga taaaacaaag gggtgcggag attttaggag 2759041 aatacgtttg gaggcgggtg taaaggaagt atcgatgaag cggagacagc gaagaaagct 2759101 ggcgctgttc cgtacttata caggctttat cacggatgcc tgggcttggt cgattaattg 2759161 gtccagcttt tctatttttt ttcgtgcggt tgaaggatca atttggcggt aatgatggtg 2759221 gccgcccggc tcttcatcca gttcgtccgc ttttttgaca atctgctgca gtgtgttttt 2759281 atctaattcg ccttcaggca aataggaatc tgtatgaagc aaaatggcta gtgcaatctc 2759341 ttttgctgct ttcggttcct cgccaagccg aatcagaagt ttatgcgccc gttccgcccc 2759401 tttaatggca tgaatgtcat ttcttttgta tttctcataa tcccactttc cgtctgtata 2759461 ccattcataa tggccaatgt catgaagcag tgccgctttt gctgctaaat caggattaat 2759521 gtcagccttc acagacagcc tgtatgcatg ataagcgcag gcaatcgcat gtgccacgcc 2759581 ggaacgctga agatattttt gtgcaattgg atgggtgaaa acatccatta atgtaacctt 2759641 tctcatggaa acccctcctt tagatatttt tagaatccta acataatttg cagagaaact 2759701 caattcttat gtcacatcat tttgatcttc ttatcatcat tgttataccc taaaagcaac 2759761 gtttcagtca gtatatgcgg ctgttcaata aaatgcgctg gctgcagcct tttgtataaa 2759821 aaaaagagca gaaaatatct gctctacaaa aactctttaa tatcataaat gcggccgttt 2759881 tccgtccctt tttctagtaa agaaagcagc gtgccggcaa taaagtccgg actgcgaagg 2759941 cttcctgttt catttaattt ccggaatcgt tcaatgtggt ggaaatcctt tttcgatgaa 2760001 gaacggatga cggcctgcat ctcagtgtcc atcactccag gtgagaacga aatcatgttc 2760061 accggcagct cttcatcctc ctgttcaaat ccgaatgtcc tcgtaaacat gtcgagcccg 2760121 gcttttgaac tgcaatacgc gctccatccc ttatatggat ttttggcggc tcctgaagta 2760181 atgttgacaa ccgtcttttt gccgctgtat gaagcaaacc gttttgtaaa cagctgactc 2760241 aaaagcacgg gcgcagtcag gttcagctga taatggcgct gaagctcgtc aagagacgct 2760301 tcgccggcac gtttgatcgg cgttaccatt ccggcgttat taataagggt aataccagaa 2760361 taacgatctg aatcgatgga tgagagcaat gtttcaaatt gctgttcagc ttcttcgaga 2760421 ttgatgaggt ctatttgatg ctgcgttagt tttttgtgag agacatctgt tttcgttctg 2760481 gataaggcat ggacttcatg ccccttttct aaagcctgta atgcaatggc ttgacccagc 2760541 ccttttgacg ctccggtgat gatataaagt tccattggaa acctcctttt ccgttattat 2760601 tgtacggcac ctcttttaca caacacaagc acgcggccta cgccttcttg ttttcctgcg 2760661 ctgtgacttt tgggatgagg aacacgatgc ctgcaattcc gagcaggatc agtacgacat 2760721 agatcatcgg cagcagcaat gatgatgttt cttgttcatc ttctgtttcc gttgatgatg 2760781 tctttgtcat tggtttttca gcaaaagtaa ttccaagctg tttcgactgg gccgcaatcg 2760841 tgttggaatc ctcggcattt gttgatgtaa acaaatcttt tatcagctcg gcgtccttgt 2760901 ccttcggttt atcaaaagtg atatcctttt gttcctcagg cagttctgtt ttttcttcat 2760961 agtaggtatc ttcatgcaaa taattcgtat cgatttcgat gtcttttttc tcatactggt 2761021 ttggcgcgac atctgtattt tcttcagttt gggcagccgc tgcagagggt atgaaaaggg 2761081 aaaaggagag catacaaatc atgatcccct tttccatgct gcgatcacgc ttcatacgtt 2761141 tcatcgcttt ctgctgtgtg ttcagccatc aaccggataa tcagcggcag agccacggca 2761201 atcaccgtaa tgatcagcag aactgttatt cccattgtaa acaagtgccc agtaccgtac 2761261 tggatgtcga tatatacttt cgaaaccgga tcttcaaatg taaagttcgg catgatcaaa 2761321 tcaataagcg gtgcgacata gaataggatc attgctgctg aagcaaccca gccagggatt 2761381 gatccgaatc tgaatgccgt ccggatgaag gcagagcttg cgaccagcaa tagaatcgta 2761441 aacaccgacc acttaatcgt ctgatcgtcc ggcagtgaat aaatattcaa gccgaacaag 2761501 ctgatcataa gtccgacaag gatattcaga attccgaata acgctccttt gacgagaagc 2761561 ggtgcgtttt ggtaatacga gctgaaatag ccgattaaca gactgctgat caacacaatg 2761621 acaaggatga caaccggagg taccgtctga attttttctt ccggaacctc tccgctgatt 2761681 ttaagcggat tcgctaagta atcatataca tagccattgt tttgcccgtc tactaatgta 2761741 tttccgagta tgccgtatac gtcatttcgc acgagtttcg tggaggcgac atttttcccc 2761801 cagttgttgt ttaaggtgtc ggctttcgct tgaacatcat taacgctttg ctgcatgttg 2761861 gttgtgtaat caatgatgcc ggactggcga tcagacaatg aacccatcat gtctgacatt 2761921 tgcagcactt cctggccgac cgtatcttgg acactcagtg ccatggtacc agacagccca 2761981 tcgttgctga acgtcgcaga ttcctgtgtt gcgcccgtta caagctgttc tgacgctttt 2762041 gcggcacttt cagagatttt cgtcagttcg tcgagaacac ctgcttgaga gtcacggata 2762101 tagccgctgt agtcgtccgc aaatttggtc atgccgtcga tgaagctgtt aatatcctca 2762161 tctgtttgca tcgtgttgtt tttgagagct tcccagctgg ctgattcttc aggtgtgaga 2762221 gccaggactg attggacgtt gccatcttgc tcttggatga cttcaccttt aataatagtc 2762281 aaagagccta gatccagatt atcatttagc gtagacttat ataaatttaa agagttgtaa 2762341 tacttcatca agttagaaat attatcagtt tcaattctac ttgaaaaaat tgaacttagt 2762401 ttttctttct gatctatata gcctctactc tgcaaagttt gtattatttc gtcttccaaa 2762461 ttgtatatta acctataagc atcattgaca ttattatcaa aatcaaccaa cttttttgtt 2762521 aagtcaccaa tttgatcatt taattttgaa actgttttat ttaactcttt aatttcttga 2762581 tttaactcat caatatgttt ctctagtttg ttgttatgtt cctcttgttt ttcttgaagt 2762641 gcattttcta tttcctctaa ttttatcgct gcttcgttca gacgtttttt tgcacctgaa 2762701 atatcagttt caccgtcagc tccgtcaccc tgtagcccat cactttgatt tgagccatcg 2762761 ttttcatctg cgagttcaat caaagagaaa tctgttttag aggttcctgt attctccgtg 2762821 tttgtatctt gttcaggaac gttttttgaa gattcttgat gtttttgtcc cgtttcaatg 2762881 ttagtttgaa catcattttg tgatccatta tcttgagtac cctcttctga tgagccagta 2762941 tcttcatttg ttggctgatc atcggatgtt ggaatatcat tcgacggttc ttcagtatta 2763001 ggagaatcat cggttgatgg ttcttcagca tcgggtgttg ttggtttttc ttgttcaggt 2763061 tcttttaacc cttcagagat atctttaatt tcagttgcaa catttttgag ctcatcccgc 2763121 tgcttctcta aatccaattt tatatcttca atatcttcct tatctgtgtc atctttatta 2763181 tcagatgtgt cttctccatc ttccttttcg tcgctttcct taggtttaag taaactaagg 2763241 cggttcttcc cgatattctc ttgcaattga tttaaatttt gatatttaat agcttcatat 2763301 tgacttttat atcgagatag aaatgcatta aacatgtcat tctcaatttt tttcataccc 2763361 atttcttgca atggcacttg attttgcctt aacttttcag cattgttcaa cgcaaggttt 2763421 gtcagtccta tttgtgtctt cgcttggccg atcccggttg ccaatccgct catgcgttcg 2763481 ctgaactgat tcgccttttg ctgtgcctgg atggcatcca gacctgtccg gatttgctgc 2763541 tgtgttgaat cctgggctgc caaaagcagc tttttctgat tctcttgata ttctttgtac 2763601 ctttcaactg tatcaatgaa ttctttcagc gtgtttttgg cttcctccgc cgtagaagct 2763661 ttttcttttg tcgtgccttg cgcttcattc attgatttct tcagctcatc gattaagtct 2763721 ttttgctgtt tgatttcacc tgctaaatca ttagagcttg gtttgtaaaa gttgtacatg 2763781 acattctgga attcagattc tttattgacg atcttgtcaa attctcctct gatgttgtcc 2763841 actttttgcg aaacaaaatt ccagtataag gccgacattt ttttgttcat tgtcttttgg 2763901 gcatcctcaa gctcacgctg aactttttct ttgttaaccg cattcaggtt atcttgaatg 2763961 ctgaattcga gcgttgcctt ttgaggatgg tctttgtcat agctcaaaat gttttttgag 2764021 aagtctgagg gaatgtagac aatcgcatcg tatttctttg aagcgagacc ggtctcggcc 2764081 gcgcttcggt ttacgaccgt ccacgaataa tcaggacgtt cacccagaac ggccgctact 2764141 tccttgccga actgggcgga tttgtcctct tcatcagact ttacctcatc actcaatacg 2764201 cctgtgtctt cattcaccac cgcgatttgc cgggtagaat tgactgcttt tttcgttggg 2764261 tcgtctccga taaatcggaa aaacaacacc ggcagcagca aaatgatgat gacggcggat 2764321 attaacttga tcaagctttt tcgttgttct gtcatctagc actctccctt tcagcagaac 2764381 ataaaggaat ttgaactttt tgctccttcc cgttttccac aacatatccg aagcccggct 2764441 gaatctcagg ctcctgtctt tggtacggga gaggaatgac attttgctca gactttttca 2764501 tcagcagaat cgcgtggcgg atttgcttca tctcagtcgt caaggagtca tagccttttg 2764561 agaattcgct gtggtttccg cccgggataa agctgaaccc aagatgagcg tatgatttca 2764621 tgaagttagc gagacgatct tgtattctcg tatcaatcgt ctgctggaat ctcgttatcc 2764681 cgtcaatcat cagcacgact tgtgagaatc gcagattttg tgcgtctcct tggcggacgg 2764741 cttctacata catggcttct cttgttttga aaatgtcttc tgctgtttca atccactgct 2764801 caatatcttc tttcgtttcc aaatatgaaa catctgattc cttcgcataa tgagataagc 2764861 cgcggtcaat cgagtcaaac aggccgatca tttcggtttc atcatcaatc agatgttcaa 2764921 gcatgacttt taggacgttt gttttcccgc gctgagtttg gcctaaaatc aggcagtgct 2764981 tatgcttgcc caaatcaaaa tagactgggc tgactgtttc ttcatgaagc ccgatcggta 2765041 cagataaagg cttgcgttcc agcttgaagc ggatagacaa ttctctcgtc gacaagctct 2765101 caggcagcat cggaatcggt gccggctgct ccattgaagc aaatcgccct tgaagtttct 2765161 gtacgtctga tttcagctcg ttgaacatgc cgatatcatc atcggcgtca acaggcagga 2765221 acatttgcgc gaaataaagc tcttcctttt gaatgatgac gcgtcccgga atcggctcaa 2765281 gattgaattt cggacggccg taaatggaat atccttctga ttgatccatg agataatgga 2765341 caatctttgt tttcaagtta tttaacaatg actggcggac agcattcacc cgcgttgctg 2765401 tcagcataaa gtagataccc aagctttgtc cgtctctgga aagctggaca aattccgatt 2765461 caagctcatg catctcatcc ttgacaatgt caaagttgtc aatggtgata aaaatgaatg 2765521 gaagctcttc ttcgctcagc gcattgtaca ttttgatgtg gctgatttct ttttcccgga 2765581 acaaacgttt acggcggtca atttcttctt tgatgcgaat catgaacttt tcaattttcc 2765641 ttgactggtc catcaggaag taatccgcgg tatgcgggag cttcgctaat ggcagcagcg 2765701 ttccgtttcc gaaatcaaag atatagacat gaagctcttc aggtgtgtat acgtccgcaa 2765761 aactcatcag gaacgttgcg gctgcaatcg attttccgta gcccgaagag ccgaagatgc 2765821 cgatatttcc atcttccatc atcttataag caattggcgc ctgtctttgc agatcaggtt 2765881 catcgacata cgcaaagtgg aaatggtctt tttcgtttga agggaaaaga gtgcgcggaa 2765941 tacgttccgc aagcggcggc agccaagggc ttggcagctt ctcgattccc atttcatctt 2766001 ggatgcgttc aatttcgtca actacagctt cgatttcggt ttgaacgtct tttttcgcgt 2766061 tatcttcggt atcaacctca gaaagcggga tcagacccgt atctgtgacg atcgcgattt 2766121 catcctcggt accgtagact tcctctaagt aaggcgcccc gctccatgca gattggaaca 2766181 gctcatacac ttcattgttt ccgacctgca aatagccgcg gcctgttacg gtaatgtttg 2766241 cggcatcgct gtttttcaaa atttctttac tgtcggtggc atcctggacc ttgagcgcta 2766301 ctttaaagcg cgagttactc cagatctggt cgtcgatgat gccgcctggc ttctgtgtcg 2766361 ccaaaatcaa atgaacgccg aggcttcgtc cgatacgcgc ggcactgaca agctccctga 2766421 taaaatcagg ctcctcgctt ttcagctcgg caaactcatc agaaattaag aacaagtgag 2766481 gcatcgccac ttctgctttc ccttgcttgt atagctttgt atagtcattg atgtgattga 2766541 cttgatactg gtcaaacagg cgctgccttt tttttagctc gcttttaatg gaagcaagcg 2766601 cacgcatact gaagtttttg cttccttcaa tatttgtgat cgtgccgagg aggtggggaa 2766661 tgttacggaa cggctgcgcc attcctccgc ctttatagtc aattagtaag aaagccgctt 2766721 catgcggatg aaaatgcact gcaagtgaca agatgtaggt ctggagaaat tcacttttcc 2766781 ctgatcccgt tgtccccgca agcaagccgt gcggaccgtg tgctttttcg tgaaggttca 2766841 gatacacaat gtcatctttc cctttatagc cgatcggcac tgacagcgac ttcgacgatt 2766901 cacttgtcag ccatctttgc tgaatgccga tttcttttac ttccttcgca tgaaaaagct 2766961 ccaggaacga taccgtttcc ggaatggaat tcgtaatgcc gacctggtgg ttcagcgtcc 2767021 gcagtgtgcg tgaaaaccgt tcgttatcct cacgctgatg atgatcgaga cggaacggaa 2767081 ttcttaccgc ttttttcttt tgtattaaaa tgtcgccttc atgctcatta atgtagcgga 2767141 caagagttgt aatgttttcc gacaagcttt cctttgtttc tgcagcgaca attgtcgaga 2767201 tgcccagatg ctcatgctgc ccttctaaat attcgagaat gacatgctca gagatcagct 2767261 gctgattcgt gatgacaaat acaaaatgcg gtttgaactg cagtttttct ttgtcatctt 2767321 cgagatcacg ctctctgatc aattcgtaaa gtgaagacag gagctgatct cgggtttgct 2767381 cattataaat aaatcctttt gcataaatat ggggcatttg aaattgcgga agccacttca 2767441 tccactccca gtctttatac tcttcttcat gaaaaataaa tacgaaacgc aaatcgtgat 2767501 agctgttaaa gaacgacagc tgtccgatta gctggtgaat ctcatttttc acaatttgtg 2767561 atttaccgac aagccccatc ggaccttctg ccaaatcgac cgtcaccggc gcattacgga 2767621 tatctttata gacgcgttgc atgtgctgcg atttctccat gaggtcatcg atatcacgat 2767681 tcgccaagtc tccgccactc atattgattt catagcttga cggaactgtt cccgtcccaa 2767741 gccgcagctg gagataatcc ttgctttcaa gtgatttttc ccagatccgg tcactgattt 2767801 cacttgttaa gtatttcatt tgttcaaatg aaggaaagtg aaattcaaga acctgctttt 2767861 gcttttcagc aagtgcctga agctctttcc gcttattgtc taagtaaagc ttatatacac 2767921 gctcccgttt ttcctcgcgt tttttccgct ggtttttatc acggaaatat tgcactgtcg 2767981 aggtaatgag agtcatcata aacatcgcca aagaaacgag tataaatatg ccgcgcggct 2768041 ggatgatggc aactacgccc atcacgatca gcatcacaag cggaggcagg atgacgagcc 2768101 acagccctct gttggtttga tcgctctcct gagagggaaa actgaaagaa acgcggtcat 2768161 ccggcagatc gtataccatc cgcggcgttc ttctgtactg cggatatttt ttctgcatct 2768221 ctgtactcgg tttgaccgtt tctgttaacg ctgtttcaaa ctgggcataa tgaacaattt 2768281 ctaaaaggtc ttgttccgtc accctcattt gcgtgaagtt ccagaatatt tcatcccccg 2768341 gcttgagcgg cgtattggcg ttgattttct ctccgttcaa gaagatcgtt ccgctttcag 2768401 ggcggaccga ccagctgccg cctgcacgga gcaaagaaaa cgtgctttgt tctgcaaatg 2768461 caaaatcttg cggattcaga taaatatctg cattcgtttt ttctgaggaa catacaattt 2768521 catcccgatt tcccgtaaaa taaacggatt tctcaggttc actgcccgtc aatatcaagc 2768581 gtatatcctg ctgatccgtt tggagagtaa atgatatatc cgtctcaatc gtgccgagac 2768641 aatcatttcc caggaaaact tcgtattggc cgccggattc ctttctttta agagaaatca 2768701 ctccgctatt aaatggaatg gtgctgatcg taacagaatc cttcacatca ggccctatgg 2768761 tcaccggatg agacgacggg aggttagaca gatttaattt ttgaacgtta ttttggtaaa 2768821 aaacccataa tagactcaaa tggcgaaccc ccttacggcc gaatggcagc atgcgatgac 2768881 ctgcgcttca tgtctcacgt tatttgtcat cttttttctc atctttcttt tctgtttctt 2768941 ttttctcgtc ttctttttcc ttctgttctt cttttttcgc tttttcctcg gctgcggctt 2769001 tttcttctgc cgctttctct tctgcttgtt tttcttcgtc tgtttgtgtc tgttcttcgc 2769061 ttgtatcgac taacgatgtt tcagaattag actgtttatt ttcttgacgt tctttttggg 2769121 ctttttcaag ctcactattt actgaatcaa gttctttttg tatgtcttca tcatttgtat 2769181 cctcagataa aagctgctgt ttatatttag ctagggcaaa gtaaatataa tcattgtatt 2769241 ccagcttacg gccgatactg atcgcttctt tgtattctcc tcgaccataa tcaatccaat 2769301 ataagaaatg ctgagggtct gattgaaggg tgactaaatt attttctata tttttggttt 2769361 ttgcactccc caggttttcg acctcaacat aggacgtcgc cagctgatac tgcaccgatt 2769421 caggcaggct ttccgcatcg tacttggaca gtgtgctgat gacttcactg tactgcttgt 2769481 ttaagaacgc acggttgctg tccactatcg cctggtgctt tggctgcgcg aaaaataagg 2769541 cgtacatcga ataaataagt gccggtacaa gcaaaacaat gagccccagg ccgatatatc 2769601 gctggatgtt ccacttcttt ctcgggatat gtatgtatgt ttttgctttg gcttcgagct 2769661 catcaatatg ggtttgaatc agctcgagca aatcatcata ggattcagca tctaatatcg 2769721 cctttgcctc tgcggagaac gtcagcgttt cattgaattt caggtagtct tcaaacgcaa 2769781 aagcgccgtc aactgccaaa gccgctgccg ctttcagctc ctgccatact ctttcctcat 2769841 cacgctcgta aggaggaatg ctttctttta ctccataatg gagaaaataa ggcgtaagcc 2769901 ctttatcgaa tacaatgttt tcaggagcga caatcaaatt cagcctcgac agattgtgct 2769961 gctgtacggc ttgaacaagc tgataggcaa actgccattt acttttttta tccttagctt 2770021 tcatgaagcg gaatgcttta taggaggagg gaggttggat tgtgatgatt acttcatcat 2770081 ccgtcacatc gatttcttta tgaaaaaatg gatttatatc tttgatcacg ttagcttcaa 2770141 gaccgtcgag aagctttatt ttttcccgtt gaaaggtaaa tgtatagccg gcatctgttt 2770201 tctcggcaac agcttctaat tggttttcta aatatgattt ttgttcacct gacattcaac 2770261 cagatccttt cataatattt caagccggtc tccgtttgta atgccgcaat cagacagctt 2770321 gcattctccg gaaaacacct tatccttgtt caccactctg atccagtgcc cttcgcgcgg 2770381 aggcatagat acgctttggg cctgccaagc aatatcaatt acttttttca ccgggtggta 2770441 atctgacaat ctgagatcaa agacactgcc gttataatgt ttcaaatcta ttgtaatatc 2770501 aatatacatt taggatcacc cttacataga aagagcgccg tcttcttttg aatcaggcgc 2770561 tccttccctt tcatactgtt atccgcggat ttgatttgcg atgtcttggt cagtagactc 2770621 aagtgtattt gctgtttgat caagctgctg attcacatct tgaagcaaat ctgacatttt 2770681 gataaatgaa ggtttgagct gctcgtattg atctgcgaac gcttcgcttg aagcaccttc 2770741 ccacatgctt ttcaaatcag agatcattcg gtttaaacga tcaacctgat ttaatacttc 2770801 ttggctttca acgccgtatt gcttcgccat cgctcttagc tcttcgggtg tgacacgaat 2770861 taatcctgcc atattcctca ttacctcctg tgccatcagc ctaaatatgg gctaattcac 2770921 ttatttttag aacgtcatta ttataaaaac agtttttcgg catagtcaaa caaatatgtt 2770981 ttaattttac aaaatgagtc caatggttta ccccgaatca ctcaaaaatg acatatactg 2771041 taaagtaaat aggtttattt tcttaatctt ctcttcattc tccgaataat ccaaaagacc 2771101 caaataactc tccaactccc aaaaaaaacc tttcagaaaa tttgatgcta cagcaccatt 2771161 tctgaaaggt tcagtttttt ctttccttaa ttagtcttgc ctccgatgac tttcttagaa 2771221 gattaatagg ataagctgtc gtattatatg agacatacac tgtcctgcaa aaaggcgatt 2771281 acaccgccaa atgtatatag aacgtttctc tcatgaaatt gtttttttgc ttctgttctt 2771341 tgttgttgat tttcacaaac aacaacaatc ataataaaag gaaggggatg agatgtcaaa 2771401 gagaaatcaa gcacgaaaag tagggagatt tatgaccatg ccgaatgatc cgtttaaata 2771461 tagttttgac agacttgaag atgtggctga tcatatcagc gacgttctgc ggtgcccgat 2771521 caccatagag gatgttaacc acaagctgct tgcctacagt acacacagcg actgcacaga 2771581 ccctgcccgg acgtctacca ttattggcag aagggtaccg gagaaggtga ttaacaagct 2771641 gtggaaagac gggacaattc ctgctctctt aaaaacggac cagccgatca gagtcaagca 2771701 aatcgatgaa gtcgggctga gcaatcgcgt cgctatttcg atttggaaaa acaagcaagt 2771761 acttggcttc atatgggcgc ttgagatcca aaaaacattg tccgatgaag atctgctgac 2771821 attgcaaatg gcagcaaaag cagtgaaaaa caagcttctc aaacttcaaa tcagaaaaac 2771881 gaaaaatgaa gaacgcagcc aagaattttt ctggaaaatg ctgaccggac acatccatca 2771941 ggaggatgat atggcggatg ggttccataa gcttggaatg gccgctcctt cagagttttc 2772001 cgttatgatc atccgcataa atggcgagct gactgaaaaa atcgaacagc agctgcaata 2772061 tttacaggaa acgacccagc aggtttacgt gctgctggcg accgtagatt ccaatgaact 2772121 tattatatta acctcaccca aaacagatca tccttttcaa gatttaaaac agtttgcttt 2772181 aagtacgcaa aaacagctga aggagcggta taaaatagaa gacgtttcta tcgcttttgg 2772241 cggaatatac aactctattt cttttgtctc ccgctcctat caggaagcat tgtccgtctt 2772301 aaaaacgaag gaacggttcg ctgaagagac caaacatctt ttcagctttt ctgagttagg 2772361 catttatcaa tacttagatg tcttaaatga aaaacggaaa caggcgggcc attataatta 2772421 ctcgctttcc aaactggaac aatatgaccg ggatcaccag tcaaatatgg tagagacgct 2772481 agagcgcttt attgaagcgg acagcaacgt gaataccgct tccaagctgt taaatataca 2772541 cgttaatacg ttgaattacc gactcaagcg gatcagccag atcgctgaaa ttgatttgaa 2772601 aaatgtgaat caaaaattca ccatctattt agatatcaaa cttcggcaca tggatttgtg 2772661 aaatttcaca aatccatgtt tttttatttt cttaatcaaa caaagaattt tccaaaatat 2772721 caagctacac taaaaatatc acatatacag gaggagacag atatgatcat aggggttcct 2772781 aaagagataa aaaacaatga aaaccgtgtc gcattaacac ccgggggcgt ttctcagctc 2772841 atttcaaacg gccaccgggt gctggttgaa acaggcgcgg gccttggaag cggatttgaa 2772901 aatgaagcct atgagtcagc aggagcggaa atcattgctg atccgaagca ggtctgggac 2772961 gccgaaatgg tcatgaaagt aaaagaaccg ctgccggaag aatatgttta ttttcgcaaa 2773021 ggacttgtgc tgtttacgta ccttcattta gcagctgagc ctgagcttgc acaggccttg 2773081 aaggataaag gagtaactgc catcgcatat gaaacggtca gtgaaggccg gacattgcct 2773141 cttctgacgc caatgtcaga ggttgcgggc agaatggcag cgcaaatcgg cgctcaattc 2773201 ttagaaaagc ctaaaggcgg aaaaggcatt ctgcttgccg gggtgcctgg cgtttcccgc 2773261 ggaaaagtaa caattatcgg aggaggcgtt gtcgggacaa acgcggcgaa aatggctgtc 2773321 ggcctcggtg cagatgtgac gatcattgac ttaaacgcag accgcttgcg ccagcttgat 2773381 gacatcttcg gccatcagat taaaacgtta atttctaatc cggtcaatat tgctgatgct 2773441 gtggcggaag cggatctcct catttgcgcg gtattaattc cgggtgctaa agctccgact 2773501 cttgtcactg aggaaatggt aaaacaaatg aaacccggtt cagttattgt tgatgtagcg 2773561 atcgaccaag gcggcatcgt cgaaactgtc gaccatatca caacacatga tcagccaaca 2773621 tatgaaaaac acggggttgt gcattatgct gtagcgaaca tgccaggcgc agtccctcgt 2773681 acatcaacaa tcgccctgac taacgttact gttccatacg cgctgcaaat cgcgaacaaa 2773741 ggggcagtaa aagcgctcgc agacaatacg gcactgagag cgggtttaaa caccgcaaac 2773801 ggacacgtga cctatgaagc tgtagcaaga gatctaggct atgagtatgt tcctgccgag 2773861 aaagctttac aggatgaatc atctgtggcg ggtgcttaat tcacaataag cttgcagaaa 2773921 gatttctgca ggctttttta ttttttaaaa ggaaaaaaga gaccatttca cgaattatga 2773981 ctatgaagtt gatcataaag gaggattcat atggctgttc agcaatatgg cgtgttaaaa 2774041 ggcatagtat tagacatgaa gcgggaaaca gatgatgaca gtcctcattt ccaagtcaaa 2774101 atgctcggtg aagagaatac gtattacagg tgcgccatca atgtgatgtc cagttctgag 2774161 gaatctgaag tattgtattt ggctgacgat cagtttgatt cgggctcaat taccatcctt 2774221 ccgaacatgc cgtatggata tacaaggatc aatgaagcaa accgtgaagt ggcactggat 2774281 tatgtgcggg gcaatttgtt tgacccgcgg gaaatgaagc ctttgcctca tgaaatcacg 2774341 ggacctgata atgatttaaa tgattttatt gaaacctata tgaagaaagc acaagatgag 2774401 aaaacgccgg tttatatatt cggttcaaaa ttcggccctg aacaggctgc agataaaata 2774461 ttcggcttta ccccgactaa cggaatgcac aatatccata tgaatcaagg gaatgcaatg 2774521 gatacccgct ggaaaaaaga caacggctct tggcatgacg ggggtattct gattcagttt 2774581 gcagatcagt gggccgctgt gtttttagcg tttttatccc aatcttggtg taccgatgaa 2774641 aacggaaacc ctgtcagaga ttgtgatcat acccaaacgt ctgcgtaaga tagaaaaaga 2774701 gactgcggca agcagtctct ttttgataag attacacatt ttcaacagtc tttaggctgt 2774761 ttggcctcat atcgctccaa tgcgattgga tatagtccaa acaagcttca cgcccttttt 2774821 gctcatgaac gactgtccag ccgctcggca catctataaa acccggccat agggaatatt 2774881 ggccttcttc attgaccagc accaaatatg tgccatccgc attttcaaaa ggatttgcca 2774941 ttctatttct cctcccttat ttattcaact cttccaattt gacagcgaga accttgccga 2775001 tttgagccag aggttcaggc tgacataaat ctttatgacg gcagtcgatg tcgatttgtt 2775061 caatctgtcc gttaatataa ggcttccacg agtcaggttc aatcgggtca aaccattcag 2775121 gaatgattgt tgatctgaaa aacaaaacat ttccgcggaa ggttttcggc ttataggaac 2775181 ctaaaatgcc gacagaattt acatacgtat tcttcaaatt taaaatgacc gtttcatcca 2775241 ggctcgcaag cgcactgccg tcacggcgaa gaatctcaat cgccgcttca aaatctagcg 2775301 gtttttcccc taagctgtct ggatcatacc cgcctaacgc cagaagggca ataagcgctt 2775361 cctcatcatc cggtgcctct tttataggaa ggaagtggtt cggataggcg tccagcatca 2775421 ccaacaggga tacttcttct ccttgatttt gcagctgggt agccatcgct tgaacgacat 2775481 tcccgcccag ggaccagccc agcagatggt acgggccttt tggctggacc gttcggattt 2775541 gtttaatgta atcggcagcc atgtcatcaa gtgttttcgg aagctcctcg cgctgcccga 2775601 ttccccgtgc ctgcaagccg tagatcggat aatctgttcc tatattggtc atcaaaccgg 2775661 cataacacca gctgagcccc cctgccggat gaacacagaa taaaggaggc ttgtctccgc 2775721 ttgttcggag cggcagcaga acgtcaagag cgctttggct tgatcccatt tcaagtcttt 2775781 cagcgagccc ggctacagta ggtgcttcga acaagttgcc gatgctgagt tcaacgccga 2775841 gcgcttcacg aatgcggctc atgagctgta cagcaagcaa ggaatgtccg cctaaatcaa 2775901 agaaacggtc atcaatgccg acacgcggca agtgaagcac ctccataaag aggtcacaga 2775961 gaatttcttc ctgcggcgtt ctcggtcctc gtcctgtcac tgccgctgcg aaatccggag 2776021 cgggcagcgc tttacgatca agctttccat tcggtgtcag cggcaattct ttcatcgtca 2776081 caaaggcagc aggcaccatg taatccggca gtctctcagc agcatatctg cgcagttccg 2776141 ccgtatcaaa tgtttcttcc gaagggatga cataagctgc taaccgttta tctcccggct 2776201 gatcctcacg aacgatcact gccgcatctt caagctgcgg atgctgaaca agcgcggctt 2776261 caatttctcc caattcaatc cggaatcccc gaattttcac ttgatggtct gcacggccga 2776321 catagtcgag agaaccgtca gcgcggaggc gggccacatc cccagtgcgg tacatccggg 2776381 tgcctggagg accgaacgga tcagctatga agcgttcaga tgttaaacca ggccggccta 2776441 gataacctcg tgctaacccc gctcctgata catacagctc tccggcaaca cccggcggga 2776501 ccggctgcag gcgttcatcc agcacgtata caccaagatc gggaatgccg cagccgatca 2776561 agctgtttgc ccgtaaagct gccatgcttc ggtctaattc gatatagctc acatgcaccg 2776621 tcgtttctgt aataccatac atattgataa gctgcggtct attttcaggg tggcggttgt 2776681 accaatcctc taaacggctg agttcaagcg cttctccgcc aaaaatgaca tagcgcagac 2776741 tgagtgcctg tccgagatcc ggctgttccc gttccgcctg cataaactga tagaaagcag 2776801 acggtgtctg gttcagaaca gtcaccccct ctttgacaag caggcgcaga aacgcttctg 2776861 gcgatctgct gacgtggtga ggcacgatta caagacgtcc gccatgcagc agaggacccc 2776921 agatctccca caccgaaaaa tcaaacgcat aggaatggaa catggtccag atatcacctg 2776981 agctgaaacg gaaccagtgc tcggtcgctg caaataaacg tgttacattt tggtgaggaa 2777041 tcatcacacc ttttggaaca cctgttgagc cggatgtata aatgacatat gccgtattca 2777101 aaggggaaag cggctgagtc ctatccttat tttttggatt acctgcaggg tacgtgttta 2777161 gtttctctgc cagctcggga tcatccagca cgattttcgg cacgttttca actggcggaa 2777221 tgtgatttgc agctttagtg ttcgtcatga taaacgcagg ctgtgcatct tttagcataa 2777281 aagcaattcg atcagccgga taatccggat caagagggag ataagctgcc ccggccttta 2777341 gcaccgccaa taggccgaca gccatttcca acgatcgggg cagtgccaat gccacaaatt 2777401 gctccggccc gacaccttca ctaatcatca ttcgggcaag ccggtttgct ctttcattca 2777461 gctctgcata gctcagttcc tgattttcat atacaacggc aatggcatca ggacgtaaag 2777521 cagcctgctt ctcaaattgc tctggcaaac atgcgtgcgg aatcttttca gatacacttt 2777581 gccaatcagt caccatgctg ctgtgttcct ctggcgcaag aatatccaga tttccgattt 2777641 gctcgtcagg atcagactcg gcagcctcca acaggcgcat caatcggtca gcaagagcct 2777701 gagcagtttc ccgtttgaaa agatcagtgc tgtattcaag cagtccttcc attccgtttg 2777761 gtgtcccgtc agcaaggcga tcttcactaa tttccagcgt caaatcaaac ttggcagaac 2777821 cgacactgtt gattcgcagg ctgctctcca tatcaggaag atgcagttca gcgtccggtg 2777881 tgttttggaa cgcaagcatg atttggaata aaggatgcgt cgcacgcgaa cgagccggat 2777941 tgagcacctc tacaagtctc tcaaacggca gatcctgatt gtcataggcg gccagattca 2778001 cttcccgtac tctgtctaga agctcacgaa agcttgggtc accggacgta tcagttctga 2778061 gcaccaatgt attaatgaac agccctacaa gatcgcccag cgcatcatca ttccgtcccg 2778121 cgatcggact gccgatcgga atgtcggtgc ccgccccgag ccttgtcaat aaagcggcga 2778181 gaccggattg aagcaccata aacaggctca ccctatttgc gcgagccagc tcctgcaatc 2778241 gcttgtgaaa ctcgggctca atacgaaaat gaatcgtatc tccatcatga ctcggctcag 2778301 ccggacgtga ataatcggtt ggcagttcaa gctgatcagg caggtttttc aaggtttctt 2778361 tccagaaagc aagctgtccg gcaatcaagc tatttggatc atcctcgttt ccaagcagtt 2778421 cttgctgcca aagcgcatag tctgcatact gcacagcaag aggcgcccat tcgggagatc 2778481 gtccgtggca gcgagccgca taagctgtcc caaggtctct ggtcagcggt gttaaggacc 2778541 agccgtcccc gacaatatga tggacgagaa gaagcagcac gtactcgtca ggaccgatca 2778601 caaaaagctc ggcacgaaaa gcaggttcag ctgcaagatc aaagctgtag cgtacagctt 2778661 cggcaagccg atcagaaagc tccttctcag caatttcagt aacatgtaac tcgggacagg 2778721 ctcgatcggc atctaaaata tgctgatagg atgtcccctg tgattcaggg aagatcgtcc 2778781 gaagactttc atgacggcag acgaggtcat aaagtgccgc tttcagcaat ccttgatcca 2778841 actcacctga caaacggaca gcaaccggaa tattataagt aggactcggt ccttccagac 2778901 aatgcaggaa ccatagccgg cgctgggcaa atgagagcgg gatcttttca ggccgctcag 2778961 ctctctgcaa agcgggacat gcactctgcg ccaaatcaag atgggcagcg agtccggcta 2779021 ctgtcggttc gtcaaagagc ttggcgatac caagttcggc tcccattacc tcgcgaatgc 2779081 ggctcatcag acgggctgca agaagagaat ggcccccaag ctcgaagaaa ctgtcatcga 2779141 taccgacgcg tgccaaaccg agaacctctg caaacaagtc acacaatatc tcttcctgag 2779201 gagtccgcgg ggcccgatca ctgacagatg tgctgaagtc tggtgccggc agtgctttcc 2779261 ggtcaagctt gccattaggt gttaacggca gctcgtccat ctccacaaac gccgacggta 2779321 ccatataatc aggaagacta gcccccatat aacgacgaag ctctgcagta tcaatagcag 2779381 catcagcgac tacataagcc gccaatcgtt tgtctcccgg ctgatcttcc cgtacgacaa 2779441 ccgcggcctg ttcaatgtgc gggtgattgg caagcacggc atcaatttct ccaagttcaa 2779501 ttcggaatcc gcgaattttg atttgatgat ccgcccgccc gatataatcc aaagacccat 2779561 cggcgcgcca gcgggcctgg tctccggtcc gatacatccg agttcccggc ggtccgtatg 2779621 gatctgcaac gaagcgctcc gccgttaaat caggacgatg gaaataacct ctggccaagc 2779681 cggttcctgc aatataaagc tctccgacaa cgcccggcgg caccggctgc aatccattat 2779741 caagcacata cacctgcgtg ttccaaatcg gtttcccaat cggaggaacg cccttcagcc 2779801 cttcttcaag aaaagctgcg gcagaccaaa tcgttgtttc agtgggaccg tataagttcg 2779861 tgactgaaca atgaaggtct tgaagttcct gcaaaagacc gctcggcagc gcctcgcctc 2779921 ctacaagcac tctaagcccc cgaagtttct caggttcact cgttaccaaa gcgtgccaca 2779981 gtgtcggtgt cgcctgcata atgttaatat cgaaattttc aatcatttga gctaatgcct 2780041 gcggctcacg gatcgtttct ttctttgcga tcacgatttg cgctccgcta atcagcggaa 2780101 gatataactc caatgctgaa atatcaaaag cgacagtcgt cacagccaac agcctgtctt 2780161 cttctcctag agaaaatgcc tcctgcatag acagcagaaa attgcttaag cttttctgtg 2780221 tcacaacgac tcccttcggt cttcctgttg atcctgaggt atagatgata tacgcaggat 2780281 ggtcaagcga aaccgataca tcctgatttt ccggcgaata gcgttttata atctcctgtg 2780341 taacagcctg atcaagcaca agctcaggta cagccaggtc atcaggcaga ctggctgcta 2780401 tttcctcagt cgttatgatg catgaaggtt tcgcatcctc cagcatgtaa gaaatgcggt 2780461 cggctggaaa ctccggatca agggggagat acgccgcacc agtcttgagc acaccaagca 2780521 ttgaagccac catctcaggg gaacgcggca gcgccaaagc gacaaattgc tccggaccaa 2780581 tccctttttc gatcaacaga cgcgcgaggc ggtttgcctc ttcattgagc tttcgatagt 2780641 tgacttgaat gtcatcacac atgagagcga tacgttctgg cgtaagaact gcctgctttt 2780701 cgaacatgtc ctgaaggctg accagcttct cggattttgc cgtctcattc catttagaaa 2780761 tgactttttc tttctcctct ggcaacagaa gctccatttg cccaatcagc atgtcctctc 2780821 cggcagaagc cgtttgcagc agctgcaaaa tacgctgctg atgaagctta atatcagact 2780881 cactgtatac ctcgggattc gcatcaacat caattcgcag cccgctgccg tctgttctgt 2780941 catatacatt gattgataga tcatcaacag gaccggctga aagattatgc gttgtgcccc 2781001 ggacgccggc aaagtcgaga ccgtaatcaa acggcataag attgatttga gggccaaata 2781061 atctatgatt ttctcctatc aatttcagat cgcgcctaag ctcttcatgg cgatacttat 2781121 gatgtcgccg aatactgcgg atttcccggg aaatttgctg aatcagttca gaaaagctca 2781181 tcgaagagct taccgtcagc cggagcggga gaaggttcat caccatagcc ggtacattca 2781241 gtgacgcgga ccctatccga cccatcatgg gcaggccgag cacaacatcc tcagagccgg 2781301 tcatacggtg cacataaaca gctgacaccg caatcatgac ttcatgccag cttcctgaga 2781361 aatagcgcgc cgcttctttt aacgcgttta catcagacgg aggcagatat gccgtatgac 2781421 gaagaaaact gttagatgtt cttggcgccc gatcagccaa gctcacaact tcaggtgcat 2781481 ctgcaaaacg gtccagccag aattgacgat ccttctcata ctgctctgat ccgcgataat 2781541 ctgtatcctc ctccaaaatg gcctggagag acccaaagga acggctttta gctgtttgtc 2781601 cttttataag ggcagtatat gtacttgcca cacgctgggc tatcagggaa aaaccgaagc 2781661 cgtcgatcgc tatatggtga atgcgctgat accaaaagaa acgatcaggc ccggcaataa 2781721 acagagcttc attgaacaaa ggggcatacc ctaaatcaac cggctttgct aaatcagctt 2781781 tcatccagtt taatgctgtt ttttccggat caggctcaga gctgacgtca atgacgtgca 2781841 gctgtacatc cggagacggg tttatcatct gccaaggccc gtccatattt tcaccgaagc 2781901 ggacatgcag cgattccgct tccttgatca cgtgccgcaa agcttcttca aaaagagcaa 2781961 tattgactgg tccattgatt tctatatatt ccgctgtatt gtagattgga ttgtccggat 2782021 caagctgctg agcaaaccat atgccagttt gcgccccggt caaagaatat tgaagatctt 2782081 ttgtatcagg catccgtttg tttaccctcc ttttataaat aatccgcgtt tggcagcact 2782141 tgctggctgc gagttgtgag caatttctgc cattcttcga tcgttgggcg ttcagccaat 2782201 tccacgaaag tcacctctgc cccttcacgg cgccattgtt ccaccaatgt catgatcctt 2782261 accgaatcaa gaccacgatc gagcaaatcc tcttgatctg tgatgtcttc cggtgtttct 2782321 tgtagaagct cagcaatttg tttacggata ttctcacatg taaacacgtt ctttttgcca 2782381 gtgtttgctg acgttttttg aacgtctgcc ggcgcattct gcagctgatc aagaagactg 2782441 tcagtcatca cggtaaacgc acagcgtcca gccgcatatt ccagcgccat ttgatgtttt 2782501 tctaatgaaa aatcagcaac tgcatctccc acaaaaaagg ctttaatatc ctccataaat 2782561 gcttcacatg ctgtaacaag acagccgata tgggcgtaaa ttcctgtaat gatcagctga 2782621 tcgcgtccct ctttgcgcat catttcaagc agattcgttc tcttaaacgc gctgtatctc 2782681 cattttgtca gcacaagatc atcatcctct ggtgccagct cggttataat tttctcctca 2782741 taaggaccgc tgtttaatcc cgggccccaa aagtctgtca gcagcgcacg gtcatccgga 2782801 ttttggcttc ccggctgtgc ggtatagaca acaggaatcc caagctgaac acattgattc 2782861 ttcagctttc gtatattcgc tgaaagctct gttaccggag acgctcccgc tgtgaaagca 2782921 tcaacaaaat agttttgcat atcgtgtatt aacaagacag cccgattcgg atcaggcacc 2782981 catgatactt tgttttgcgg catatcagat gctgtcggca tttgatacgg ctgaatggca 2783041 ggtatagcca tatgaacact tcctctcaaa ttgttgtttt attttttaaa tcctgcaaga 2783101 agcttctcgg aaatggcttc acggagcgct tttttgctga cttttcctac tcctgtctgc 2783161 gggaaggatt cgacaaattc aactcgatca gggattttat atgccgccag tccgcgctct 2783221 ctcaaaaatg ctttaagctc tgcggctttt ggggcttcat cccggggaat aatgaacaca 2783281 caagatcttt cgccaagaaa ttgatcaggc atggagacca ttgccgcatc atggacagcc 2783341 ggatgcgcca gcagatgatt ttctacctct tcagccgcaa ccttttctcc tccacggtta 2783401 atttgatcct tcgcccggcc ttcaacgaca atatagccgt ctcgtgtcag cctgacgata 2783461 tcacccgtac ggtaaaaacc gtcctcagta aatgaagcgg cgttatgctc ttctgcctta 2783521 tagtaacctc gaattgtata cggcccccgc gtcagcagat ggcctgtttc accaggtttt 2783581 acgtcgcgat catgatcatc ccaaacacgc atttcatcat atggagacat cggttttcct 2783641 tgggtgttga caatgatctc ctcaggatca tccaatctcg tataattgac gagaccctct 2783701 gccattccga acacctgctg cagcgtgcag ccgaaaacag cttttaccct gcgcgcggct 2783761 tcagcactaa acttggcacc gccgacctgc agcacttgaa ggctggataa atcatcacgg 2783821 cgtgaggatg ccgcatccat ccataccatc gcaagaggcg gaacaagagc ggttatcgtg 2783881 accttttccc gttcaattaa aggaaatgcg tcatctggac ttggagaagg agataatacc 2783941 actcttcctc cagcgtataa tacgccgaga acgccgggtg agctcagcgg ataattgtgt 2784001 gccatcggca gcgcggccaa gtacaccgtg ctgtggtcga gccagcagac ctccacactc 2784061 cgcttcaggc tgtatatgta gtcatcgtgg gtcctcggaa tcagtttcga tagcccggtg 2784121 ctcccgccag aaagctggag gaacgccaca tccgatgatt tgacttcagg cagttttaca 2784181 ggttctgcat gcaaatcctc cagcggtaaa aattcctctg cctcacctgc gacaatgatg 2784241 tttttcaaag tcggcagctt gctttgaacc tgtctggcaa gcgaacggta gtcaaaaccg 2784301 gaataagcgt cgggaatgat atatgcagcc gcttcagcaa actcgcaaaa atatgtaatt 2784361 tcactgcttc gatgagaagg cagtgcgaag actggaagcg cccccagacg gaaaagcgcg 2784421 aaaatgactt caaaaaactc tttgatattt ggcaactgca ccacaacacg atccatctgt 2784481 tgaatgccga gcttttgaaa tccggcagcc aggcgatcag cccttgtgtc aagctctcga 2784541 tagctccaat gggtgtttcc gcatgtaatg gcaatgcgat caccatattt ggctgcccgg 2784601 tcccttaaca aatctccaaa cgtctcaccg gcccagcagc cgttctttcg ataggtctca 2784661 gctaactcat caggccaagg cgtaaatcct ttcagcatgt tgtatccctc cagcaattca 2784721 ttctgttcat atgtgatcca cgcccattgc ccgcagcatt gtccgaaact ttgcggacgt 2784781 ctcctgaagc tcgtcctcag gctttgaacc ggccacaaca ccagctccag catacaggcg 2784841 gagtgagcgt tcttctgctt ctgcacaacg gatggtcacg atccattctc cgtcaccggc 2784901 atcgtcacac catccgacca tgccggtaaa gaaaccgcgg tcaaatggtt caatgctgag 2784961 aatcgcttct cttgcaagat cagtcggtgt tccgcagacg gctggcgtcg ggtggagcgc 2785021 cgccgccaat tcaagtgcgg ttacagacgg gtcggaaagc tctcccttaa tcacgctgga 2785081 caggtgccac atcgtttccg ttttgatcag tgaaggcttc tccggaacct ccagcgtccg 2785141 gcagaaaggt ctcagcgctg ccgcaaccgc gtcagcgaca accgcgtgct catgaagatc 2785201 ctttgcggaa gaaagcaatt cagctgcccg gcgctggtct tcaacaggat cattactgcg 2785261 cggtcttgag ccggctaatg ggttggaaac gacctgtgtt cccatccttg aaacgagaag 2785321 ctccggactt gctccgagca atgttctgcg gggagacgtt tcctcctgac tggacacgtc 2785381 tgcggcaaac gtgtagccat gcgagttatg ctgagccaga tggcgaagca attcatccgt 2785441 ctgaatcggt tcaggcgatg tcaaatgcag cgatctggac aggacgattt tgctgagtgt 2785501 tccatcggca atgcgtgcca gcccttgttc aacaccattt ttataatcct caggttcagg 2785561 aacaggcttt atgtggtatg tatgcccagc ctgctgttcc ttttcctcat gatcaaattg 2785621 aagcggtcct gaccagcgca cttcttcagg tacaacgagc cgcgctgctt ttacttgatc 2785681 aaaaggaacg gccccgacaa caagcggccg gctttgccct gattgttttg cctgacgtaa 2785741 cgcctctgca attcggccag aaagggtttc catttggttt tgcccgtctg cctccggtac 2785801 aatttcacat atgcctttcg ctaacagtac acgatgagga gacgctaaga aaaaggcgcc 2785861 cggctgatat tcatgaagca aatgctccgc ttttgtttct gttataacgt tttgatccaa 2785921 cattctcatg aacctccttt aaattcagtt acacgcctaa ggtcgcgccg ccatctacgc 2785981 ataaattatg catcgtaata tgccctgcct ggccagaaac caaaaagagc accgcatccg 2786041 caatatccga aggcttggct agttttttga gcgggatccc tgttttaaat gtctcaagtg 2786101 atccttttat gacttgctcc gctccattct cgtcggccca taatgaccac tgcatgtctg 2786161 tttccgttga tccgggagat acaatgttgc agcgaatatt gtattctgca agctcaaggc 2786221 caaggcattt cgtaaacatc acagccgcag cctttgaaga cgcatatgcc gccatagatg 2786281 ttcttggtac accggcagca ttcgatccga ctgttacaat cgaacccgat cttcggtcca 2786341 tcatatattt gctgactgaa cgcgaggcgt taaatacgcc agtcgaattc actgagaacg 2786401 tcgcctccca ttcctcatcg ctaagcgaat ggatcagtcc cgggcgaagg acacccgcta 2786461 cattcactaa aatatcaatc ggccccattt cacgttcgat gcgcgccgtg atctcgtcaa 2786521 tcgccgcgct gtctctcaca tccgcaggaa aagcttctgc atggcggcct tctgctttga 2786581 ggctgctcac aaccttttcc agcttttcag gattataatc aactgccgca atatgtgcgc 2786641 cttgactggc aagcgtccgc gcaacagctt cgcctattcc ttgggcagcc cctgttataa 2786701 aagcaatttt tccctctata ccctttgcat tcatatcatc aattcctttc ttcgctctaa 2786761 atgccaaaca gacatccagc gaaaaagact gctgcgcctt gaaaaacgca atctattgat 2786821 aatgattatc attatcaatt ataaaaataa tcatatccaa atgtcatgtg acagtcaaat 2786881 ataatttcag tgacaaatat ttttttaaag gcaaggctga gtatgtctca gcccattgat 2786941 agatgcggtc cgtcagggtg aagcgcaaaa cgcagcgccc tgctgaccaa aacaggaaga 2787001 actgaaatat gtccttctcc tgaaaactcg caaaattctg cccgtatacc ttgttcagat 2787061 aaaacggcca gccgctcata aagctccctt gcattatcat tcatccggct tttatgatgc 2787121 tgctctaatt ctcctgcggc aagcaggata ttgataggct gattgttttt cttggtgaga 2787181 gagacgaaat ggtccgtttt cttgagaata aacggtttat tccaatgaat ggacggactt 2787241 cccgcgatat acgtttgaaa cgcatcgggc tttgttagca gcacctgcag cacgaaaagc 2787301 cctccgagcg aatggccaaa gattgtttgt ctttttttat caatctggta atctcgttct 2787361 atctccggtt ttaaatcctc ttcaataaat ctgaaaaagc cctccgctcc gccatgctcc 2787421 ggccattctc tgccgtcggg cctttccggc agcttcgatt gggctgttgg cattgtaaaa 2787481 tcccggtggc gtgctgagga gaacggctcc gctgtctcat agccaatgcc gacgatcact 2787541 gcagggatca ccccggtttt ttcgggtcgg cgtccctgta ttcgaacggc ttccgtcatc 2787601 gttccgaaga cagaattggc atccagcaga taaatcacag gataaccagc gggtggcggc 2787661 ggcgtactag gtttcgagat aaaaatgtga taggtacggt tttcattgcg tgaagacatc 2787721 atacgcactt ccgtaccagg aatcgtaaat gcgtttgatg tcccgccatt tgtccggtct 2787781 gttgtttgtt ctttcatgca gtacgacatt cctctcctta aactaaaccg caatgtatga 2787841 taatgatttt cactatcaac tagacacctc aaataatagg ttttcttcca aagaaagtca 2787901 actttttccc gaataaaaaa ggcaccttga tcaaataagg tacctgcaga ctatcaatat 2787961 ggaagtaaaa acctaataaa gatgcgtatt gtcctatttg aaatagaacc ttaatcccat 2788021 gtaaaccttt gattttgcca agggtcgcct ctcatgtgat agccattccg ctcccaaaag 2788081 ccagggtgat tttctttcgt aaattggatg ccgcgcagcc acttggcgct tttccaaaaa 2788141 tacagatgcg gaaatacacc ccgcagcgga aagccgtgtt caggggttaa aggttcgcca 2788201 ttatgcgcat aagccagaag ggaagtttcc gctaagaaat catcaagcgg cagattggtc 2788261 gtccagccct cttcagcatg taaaatgacg tagcccgctt cttcttttac acccgctttt 2788321 tccgctatat cacaagcccg cacgccttgc cacacattat caagccttga ccatcccgtg 2788381 acgcaatgaa tgtcgttttt cgattcatac cgtggaaagg ctttgacatc ttcaaagctt 2788441 agcagcatcg gatggtcaac caaaccgtat acttgaagat tccatttcgt catatcttcg 2788501 taatatggga catctccggt atgaagcaca ggaaatgaag tggtgacgtt ttgatttggc 2788561 ggcactcttc cagattgatc ggactgtctt gtttttccga aatacatatg ggcctccttt 2788621 ttgttaacct aatttaaaat catgttgaca atctttttgt tctttattac tctatgattg 2788681 tgtatgtcaa cctaaggggg aacaacgatg aaacaacgta aacttcgtgc gggagatatg 2788741 gcgctgattg gcatgttcgc cgcacttatg gctgtcgggg ccaacattac atcagtagca 2788801 ccctttttac aagtagccgg cattccgctt tcgatgcagc cgtttttctg tctcttggca 2788861 gctttgcttc ttggcagcaa acgggcagcg attgccatga ttgtatatgc acttgtggga 2788921 ttggccggag cgcctgtgtt tgctcaattt tcagcaggct tcgcaccgtt tgcagggaaa 2788981 agcggcgggt ttattatctc atacattccg gcagcatttg cagcgggatg gtttttagaa 2789041 cgaaacattc agccaagtaa aattcgattt ctcattgctt cacttatcgg aacggcgatc 2789101 atgtatctca tcggcactac ctatatgtat cttgcactga agctgtggat tcatacgcca 2789161 gtgagctacg gcacggcttg gggctttatg atttggttta tggtaaaaga tacagcgctg 2789221 gctgtgatac tgtcgtttat cgcaccagca atctaccgct ctattcataa agcaaccggc 2789281 tttaacagaa atcacatatc atctacgtaa aaaccgttct attggacggt ttttttatca 2789341 taacgagaaa aggctcccca gtaaagggga gcctttttcc tataaaacaa gcgctgcaat 2789401 ccagccaaag atgacaagcg gaatattata aaatataaat gtcggcacac aagtatccca 2789461 aatgtggtga tgctggccgt ccgcactcaa acctgaagtc ggcccaagcg tactgtcact 2789521 ggcaggtgaa ccggcatcgc caagcgcagc agcagccccg ataatcgcaa tcgttgccat 2789581 cgggctgaat ccaagctgca tgcatagagg cacgaaaatg gttgtgataa caggaatggt 2789641 cgcaaaagaa gatccgatcc ccattgtaat taataagccg acaatgagca tcagcaatgc 2789701 gcccaaggac tgactgtgtc cgataaaacc agctgacgtt ttgaccagtg actcgacatc 2789761 tccggttttc gtcaatacgt ttgaaaatcc ggctgcaaca agcatgacaa agccgataaa 2789821 ggccattaaa accattccat cagtaatcag tgagtccgct tcatcacgct tcatcacacc 2789881 gctgacaaac agaacaatca gaccagcgag cgcccccata atcattcctt ctactcccaa 2789941 agtctgagat aagtaaagct ggacgccgag tgacacaaca atggctagaa ccgcgatacc 2790001 aatacttttt ctcgtatatg gcgatgcttc tgcacctgaa atgtcttttg tttcatattg 2790061 tttcggttta cggtatacga tcactgataa aataaggccg acaaccatac ctgcaactgg 2790121 aataatcagt gcgtacggaa tatcagcaag cggaacgttt aacccggcat ccgccatatt 2790181 gtccttcagc atgccttgga agatttggcc gaaaccgacc ggaagcaaaa tataaggagc 2790241 cgttaagcca aatgtaatta cacacgcgat cagacggcgg tccatttcaa gttcattaaa 2790301 gattttcaaa agcggcggaa tcagcaccgg gataaacgcg atgtgaaccg gaacgacgtt 2790361 ttgcgaaaaa caagatacaa ttaaaataat cagcacaatc agcaccttag acagtgcttt 2790421 ttttcgagaa tcttctttat ttccgattaa tttaacggag gcttccacca ttgcgtccgg 2790481 aagacccgtt ttcgtcaaag cggcggcaaa cgcgccaagc atggcatagc taactgcaac 2790541 ggtggcattt ccgccgagac cgtctgtgaa agctttaacc gtttcgccaa gaccgagccc 2790601 gcctgttaac ccgccggcca aggcgcctat aattaatgcg ataacaatat tgacacgcag 2790661 caggcttaat acaagcataa gcaggactgc gatgacgact gcattcatga tgatacccct 2790721 ccaaaaatcc tttagtttgc taatgtagta gataaataaa gtacgaacgt atcgtatcat 2790781 aaccgatcca ctttagtcaa ctaaagattt cggaagaaaa aatccctgcc gcatcataca 2790841 gcagggattt ttcattactc gtttttatct tcttccaatg taaatcgctc cgcaagtgta 2790901 gccagtgttc ttgccataac gccagtagcc ccggccggtc cgaagcaggt tgctttattg 2790961 gcagtcgctg tgcctgcaat atcaaggtga acccaaggtg ttgactcagc gaattcacca 2791021 agaaacgttc ctgccataat cgcatgtccc tcgcgtcccg gtgaattgct gagatccgcc 2791081 atttggctgc ttttcacgcg ttttttatcc ttctctgtta tcggcagctg ccagatcgcc 2791141 tcgccgcact cttgtgcagc atcagctacc tgctggtaaa agctttgatc atttgtcatt 2791201 gcaccggttg tttctgttcc taatgccaca acgacgccgc cggtaagcgt agctacatcg 2791261 acaagaactg atgcgccatg ctgtttcgcg tatgtaatgc catctgcaag cactagcctt 2791321 ccttcagcat ccgtattaag gatttctatt gtttttccgc ttaaagatac gatcacgtca 2791381 tccggcttca tggccccgcc ggagatcata ttatcggttg atggaataac gcacagcacg 2791441 ttttgttcag gacgaagctc tccgatcgtt tccatagccc cgagaaccgc agctgctcct 2791501 cccatatctg atttcatgcc aacaattcca gatttcgttt taatggagta gccgcctgtg 2791561 tcaaaggtaa ttcctttccc gactagtccg acgacgtctt cccattcctt tttgccctga 2791621 tatttcaaca caatcatttt cggcggttcg gtggagcctt ggtttaccgc aagtattccg 2791681 cccataccga gctcttccat ctctgatttc tccaatatct cacactcaaa atcatatttc 2791741 gccgcaagct cttcagcata cgaagcgagg tcagtcgctg tcagcatgtt tcccggcata 2791801 ttcacaagcg ttctagccga atttgtccct tgtccgtatg cctggccgac gcgaagccct 2791861 gcctgcactt cctgtgtatc ttcatctgtt acaacataca cggcttcaat ttgtttgtca 2791921 ggctcatttg atttatgctt ataatcctgc acctcatagg aagcaagcag gcagctctca 2791981 gctaaagcat gagcggcatc ggctggaggc acgtcttccg aaataaacgt atcaagcaga 2792041 acagcagttt cttgttttcg atctttatga atggcttgaa aaacatgagc aaaacgttcc 2792101 ttcgcctgtt caaacgaata atttgcttct ctccccaggc caacgaaata aatccgtttc 2792161 atacccgcag aagatggagg gaatactttt gatacttgat tcggtttcgc agagacatca 2792221 ccctctttta aaagctgtgt cagatggcct tcgagcattt catcaatttc caacgctttt 2792281 cctgtcagct ggcttttttg aaaaagcccg acaacaaggg tttctgtatg ctctgattgt 2792341 tgaaccgcat aaaacatgag gcttacactc ctaacgtaat gggtatttgt aatgaacaat 2792401 ggtataatag gaaaaacatt ctttccacta tacttatttt aacaaacaac agtctaagac 2792461 ttgctttttt cttttgaaac acgaaggatt tttcaaatag aaaggatgtc gccgatggaa 2792521 cttttaacga attttccttt attatcaagc ctggccgcaa ttatttttgc tcaggtcatc 2792581 aaagtgccca tacagtttat cgtgtccaga aaactggact ggtcgctggt cacaagcaca 2792641 ggcggcatgc ctagctctca ctccgcagcg gtcactgcgc tttctacagg cgtagccttg 2792701 gagcatggat tagactcctc actctttgcg gtttccgcca ttttcgccgt cataaccatg 2792761 tttgacgcaa ctggcgtcag acgtcacgcc ggtgagcagg caacagtcat taataagctt 2792821 gttattgatt ttaaccgttt cgtaaatgaa gcgaaggact tccctaaggc tgcagagaaa 2792881 gaaaagcaaa aaaagctgaa agagcttctc ggacatcagc cgatcgaagt ctttttcgga 2792941 ggattaacag gtattttact gacattggta ctcgcttact ttttcatgta aaaaaaacgc 2793001 tcctgctttc gctggagcgt tttattcttt caccgtttta tattgatttc tgaacacttg 2793061 caaagatttt gtttcattga gcttctcaag ctcatcctcg gtaatctttc ccgttccctt 2793121 tttaatcaca tatacatcaa gggttttttt gccccattca ttgtatacat ctttgactgt 2793181 ctcaaagtac agatcaaggc ggtttccctt aatagctgat cctgtgtcgg ccacaactcc 2793241 gagaccgtag ttcggaatga ataaaattgt tccgatcggg aaaacggacg ggtcagcagc 2793301 aaccgtggaa tataaatccc gtttcacttt cacacctgaa tatgtaagcc cgtataatgg 2793361 atcaccggga tttttgcccg tcgactcagc tcctgctgtg tagcctgttg ctgttactct 2793421 ttggactgga tattcatccc aatcaaatgc ctcttctaac ggttttgttt tatcctcagc 2793481 cgcggacgtg gtttgtgttt gtttctgctg caatgctttt aatctcagtc ctgcatgctt 2793541 caagtgcttt tcctgatgtt cctgcaccca ttttgacaag tccttcgctt caattcctga 2793601 cactgataaa aatgtcgtgc caaatgcaag cagaaataaa caggtcatca gcaaacgtct 2793661 gatcatattc aacatcattc acctctcctc cgaatcattg ttcccaagtg gagagagcat 2793721 tattcaaaat ggtgaatgag ctgaacgcat aaaaaaagct ttctttagaa gaaagcggca 2793781 tttaaaacat ttgatatcct ctttttctaa gcatgttgat cgctataccg gacacgatgg 2793841 cgccggccaa accgctgact aaaatcagca catcagcagc cgctaatgat aagacacgat 2793901 gaaacaggct ggcaaaggat tctcccggcg actggacata gctgatcagc ttttctttgc 2793961 tgataatgaa aaggcataca attggataaa tcacagccat aatccaagac attctcagca 2794021 gcatgtttaa taagaaaccg attccaaaaa acaagacaaa aaacaaaaca attgagatga 2794081 ttacgactgg cagactaatc aacctattcc acccccctgc gttgttttta gtgtaacgcg 2794141 ggggctgaaa taaagtcaac ggctggaaaa agaatgactg tcttttcctg tcccctggca 2794201 agacggacaa gtctctgaac cgccgagaat caattgaaaa tatcctttcc ctgaacaaaa 2794261 tgggcatgca tgtgaagcgg ttgtcgttgc agttttcatc taatcatcac cctttttctt 2794321 aattttctga taatatacca tatcaagctg tcaacaataa agtcagatca tgtgacaaat 2794381 cttttgatgt aagcggaaac atacttgttt tcctctcgtt ctctttttat tttggcgttt 2794441 tttaataaag aaaacccgct tccgcgggtt tttagaaaaa cttgaacttg ccttttttca 2794501 atgtcagtcc gagtccgcca atcataaaca gtgagcggtt atcaatgact tttttcataa 2794561 acgaagcggg cgtgcctttc agctttctgc cataaacaac cccaaccgcg ttatgctcgc 2794621 caagagaagc cactgttccc ttaatgtccg gcttgaattc ctcaagctct ccgcctttaa 2794681 taagcctgcc aaggttttta gcgaccgtta tgccctgctg cattgcaatt tgcgcagtcg 2794741 gcggatacgg gcgctctgta tcttcattca taaacagcga gctgtcgccg agaataaaga 2794801 cattgtcatg tcccggggcg cggagatcag ggttgacttt gactcggccg cgcatattct 2794861 caaaaccggc ttcctccaca atcggatggc cgcggacacc tgccgcccat acaacggttt 2794921 gcgatttgat ctgctctggt tcttcatctt ttttgccgac tctgactcct tctggtgtac 2794981 attcttgtac agccgttccg atcttgaact caactccgtt ttcctcaaga taatgtacgg 2795041 cgtaatcaac aagttccgga tcaaagcccg gcaaaacggt cggcgctgct tccacacaaa 2795101 tgatgcggac aaggcttctg tcaacgtcat attccttaca gagctccggc acgcgagcag 2795161 ccagttcgcc aagaaattca attcccgtaa atccggcacc gccaacaacg atcgttaacc 2795221 tgtccggccg tttttccgct tccgtattgt aagtcgcaaa ctgcagctca atatgttccc 2795281 gcagcaggcg cgacgtgttg atgttggcaa tcggaaacgc atattctttt aagcctttaa 2795341 tgccgaacgt ttcaggcacg gcgccgagcc cgatgactaa ataatcgtac tgcaattctc 2795401 cattcgcaag cacaactttt ttctcatcaa ttttgattgc ctttacggta tcctgtacaa 2795461 aattcacccg tgactggttg attacatctt ttatctgata acggcagcgg tcatgatgga 2795521 gcgtacccgc gctcgcttca tgcatccatg tcgtttcata atgataattg tgtttattta 2795581 caagcgtaat gtcagcatca ttcggcccga catacttcgt cagccttgtc accgtcatca 2795641 atccgccata tcctgcacct aaaatcacga ttttgggctt attcaatgcc atcacatcca 2795701 ccttctcttt ttttgctttt gttagaccca taataaaatc atcatttgtg ttagcttcag 2795761 cttattggcg ggattttatg aaatatattg aaaagttttt tgtgaagtcc ttacccgtag 2795821 cactattatc atgtttatcc ggctggccca agaaacattc agaaaaagat catttcattt 2795881 ggttattatc gtagcggcct gcggaaatat tttcaagaac ggatgggcac gttagatcct 2795941 tacgattttt tctgctgact cgtcaatttg aacggcaata tggtataatt aataacaatt 2796001 ttcatttagg aggcaatttt cgtatgcgag aggatacaaa ggtttatgat attacaatta 2796061 taggcggggg accggtcggc ttattcaccg ctttttacgg cgggatgaga caggcaagcg 2796121 tcaaaattat cgaaagcctg cctcagctcg gcggacagct tagcgcccta taccctgaga 2796181 agtatatata tgatgtagcg ggattcccga aaatccgcgc gcaagagctt atcaataacc 2796241 taaaagagca aatggcgaaa ttcgaccaaa ccatttgtct ggagcaagcg gttgaatctg 2796301 ttgagaaaca agcggacggc gtgtttaagc ttgtaacaaa tgaagaaacc cactactcta 2796361 aaacggtcat cataactgca ggaaacggcg cattcaaacc gagaaagctg gaacttgaaa 2796421 atgccgagca gtatgaaggc aaaaacctcc attacttcgt tgatgatctg caaaaattcg 2796481 ccggcagacg cgttgcgatc cttggcggtg gagattccgc ggttgactgg gcgcttatgc 2796541 ttgagccaat cgcaaaagaa gtatcgatca ttcaccgccg cgacaagttc cgagcgcacg 2796601 agcacagtgt ggaaaacctt catgcgtcga aggttaatgt cctgacacca ttcgtccctg 2796661 cggagctgat cggcgaagac aaaatcgaac agctagtgct tgaagaagtg aaaggcgacc 2796721 gcaaagagat tttagaaatt gatgacttaa tcgtcaacta cggtttcgtt tcatctcttg 2796781 gaccgatcaa aaactggggc ctggacatcg agaaaaattc cattgtcgtg aaatcaacaa 2796841 tggaaacaaa tatcgaaggc ttctttgcag caggtgacat ttgtacatac gaaggaaaag 2796901 tcaacctgat tgccagcggc ttcggcgagg caccgacagc agtgaacaac gccaaggctt 2796961 acatggaccc gaaagcccgc gtacagcctc ttcactcaac aagtcttttt gaaaataaat 2797021 aataaaaaaa ggagcttgtg tctgcgacac agctcctttt ttatttgaag atatttatat 2797081 aattcaatgc agttcctaca accagcgcaa tcacaagggc tgcgactacc cagatcattg 2797141 ccataataat gcggtcctga atcttttggg acttcggtgt tttttcttcg ttttgggcca 2797201 tcttattcgc tcctttccca tgtccatgcc ataaagaaag cctggtgctg aacgaccaag 2797261 ctttgctgaa cgtatatcat tcgcgttttg atccgctctc taagaccatt cgttaaaact 2797321 atgataccta aactcaccct gcatgacaag cttcggcact tgcaccacac ctgccagcaa 2797381 atcataatgt ttgacatcct aaataaaaca gagtacatta tataaggcga acatttcata 2797441 tattatactt ttaaatattc gtttttagga gtgaaaacca tggaaaacgt atttgattac 2797501 gaagatattc agctaattcc tgcaaaatgc attgtgaata gccgttcaga atgtgataca 2797561 tccgtacgtt taggcggaca tacatttaaa ttgcccgtcg tccctgccaa tatgcagacg 2797621 attatagatg aaaaactagc gatttcatta gccgaaaatg gctactttta tgtgatgcac 2797681 cgatttgagc ctgagacacg aattgatttt attaaagata tgaacgcacg cgggttattc 2797741 tcttctatca gcgtgggcgt caaagatgag gagtatgaat ttgtccgcca gctggcagaa 2797801 gaaaatctga ctcctgaata cgtgacaatt gacattgctc acgggcactc aaatgctgtc 2797861 attgaaatga tccagcacct taaaaaacat ttgccggaca gctttgttat tgctggcaat 2797921 gtcggaacgc cggaagcggt cagagagctt gaaaatgcgg gagcggatgc cactaaagtc 2797981 ggcatcggac cgggaaaagt atgtattacg aaaatcaaaa caggcttcgg cacaggcggc 2798041 tggcaattag cagcgctgcg ctggtgtgcc aaggctgcca gcaaaccgat tatcgcggat 2798101 ggcggcatcc gcacccatgg cgacatcgca aaatcaatcc gattcggcgc aacgatggtc 2798161 atgatcggtt cactatttgc cggacacgaa gaatcgccag gccaaacgat cgaaaaagac 2798221 ggaaagcttt acaaggagta cttcggctca gcctctgaat tccaaaaagg cgaaaagaaa 2798281 aatgtcgaag gcaaaaaaat gcacgtggcg cataaaggct caatcaagga tacactgatt 2798341 gaaatggagc aggatcttca atcttctatt tcttatgcag gcggaacaaa gcttaacgcc 2798401 atccgcaatg tggattatgt gattgtgaag aattccattt ttaatgggga taaatattaa 2798461 tcataaaaaa acgccaagtc agcggttctc cgcttgagtt ggcgttttct gctacttctt 2798521 cagcaaagta agcttatatt tgctttttga gtttatcttc catcagttct gccatttgtt 2798581 ttgcatttgg attttcttca ttttgcaact gttcaatgac gttcatataa tccgtttcat 2798641 ttcggttctg gcttaattta tatgccgctt gaatgtcttc caccttaatc ttaaatccaa 2798701 caataccttt caattcactt tctaagagtt ttggagaaag cttatcccat aacacaggat 2798761 tgtcacgatg tttttcgtat ttctccaaca tgattgttaa ttcttctgct aattcatctt 2798821 tctctaacat acttgctttt ccatacatgt ggacagcctg ataattccac gtcggaacat 2798881 tttcgcgcga ataccaggaa gaagaaatat aagcgtgcgg tccctgaaac atcacaagca 2798941 catcttcaca ggcttcaaac gttctccact gaggatttcc ataagcgaaa tgccccgtaa 2799001 tatagtaatg atcgtctttt ttattgaatc ctaacggcaa atgtgtggca attggttttc 2799061 cttgttctgt tgtgacaacc gtaccaaagg agttttcttg tacaaaattc caaatttctt 2799121 cagcatttgt gactttaaaa tattttggaa tatacatcat catccaccct tcgaaaaata 2799181 ttatatgagt gttttagcca tgattaaatc cgtttgttct tcatcaccca tataaaatga 2799241 gtgggcgccg gtctgaacaa accccatttt cttataaaag gcaatggcat tttcattttt 2799301 ttcccacaca cctagccaaa tgttcttttt attacgttcc agcgcaattt ctatcgcttt 2799361 attcagcaga tgtttgccaa gcccatgttt ttgaaagctg ttctttatat aaattctctc 2799421 gatttcaagt gattcagcac ccatttcttc agactgagca tcatcgatat tgacctttac 2799481 atatccagcg atttcatgat caaagtaaat aaaaaagaat tgcgaagaca tattagataa 2799541 ctctttttcc agctgctcag tgttaaatgc gctttctaaa taggctttca tattttcagg 2799601 tgagttctgt tctttaaaag tgtcattgaa tgtttcaata ctcaattgtt gaagtgtttg 2799661 taaatcttcc cggctgcatt ttttcatttt tacactcatt gttcggattc agccccttta 2799721 tttaaaattc aattgtcttg tgtccctttt atatatttaa acacggaaca catactgacc 2799781 ttgttaccat tccaaaaatc ttcttcatca ccaactccct atcgtgattt tgttgtaaat 2799841 gcaataaaat atactccgca ttaaatatat cgtaactttg ctgtatttac aacaaaaatc 2799901 aaacaacaaa gcagcgtttc tcttgccgaa gttcccggaa ctctctgcat catttcccca 2799961 taataaaaac gcctccctta acgatgattt atcgctaaga aaagcgtcag taatagttgc 2800021 tatccgtttt tagtgcttag cactcttcag gcttgcctgc attcgttgct gttctgaacg 2800081 aagaaccgca gccgcatgaa gcgatggcgt ttggattgtc gatggtgaag ccgccgccga 2800141 gcatggattg tttataatca atcacggtgc cgttcatgat gtcaaggctt tctttgtcaa 2800201 ctagaacagt gatgccgtgc tgatcaaaca cactgtctga ttcactcttt tcatgctcaa 2800261 agcccatgcc gtaagaaagt ccgctgcagc cgccgccttt gacgcctaca cgcagaaacg 2800321 cgttttcttc ttcatgctct ttcatcatat cttttatatg caaagctgct gcttctgtaa 2800381 ttgttaccgg gttgctcatc attatgaacc tccttttaaa aaccggttgc tgtcttttat 2800441 tataaacatg atcgttccaa ttctcaaaca aggtgtttta caagaaatag acaccctcac 2800501 aaacggtttc agccggccct gtcatcatta catggccgtt atctttccag tttatcacca 2800561 aatccccgcc tgctaaatgc accgtgatgt cttgatttcg ctttgatacg ccgtttaata 2800621 cagatgcgac tgccgctgca catgctcctg tcccgcatgc ctgagtaatc cctgatcccc 2800681 gttcccagac gcggaaatgc aattcttgtt cattcacggt ttcaacgaat tccacattga 2800741 tgccttccgg aaatctcgga tctttctcaa tcaccggccc cagtgtcgtt aagggtgcct 2800801 gttcaatgtc tgcgatcgga aaaacgatat gcggatttcc cattgaaacg gcagtgcctg 2800861 ttagttctac ttcaccaaat gccatcgttt cattgattgt gtgctcttcc ccgccgtcaa 2800921 gcataggaag ctcggatttt gtcaagcgcg gttcgcccat atcgacagtg accacattca 2800981 cttttccgtt ttcgacttga acctccgctt tcacaagccc ggagagagtt tcaatcagaa 2801041 aagatgtttc ctcaaccagc ttatgctcat atgcgtattt tgcgacgcag cgcaggccgt 2801101 tgccgcagtt tttcccttca gacccgtcat tattaaaaat ccgcatttta acaggcgctt 2801161 ggtctgatgg gcatatcagg atcattccgt cggatccgat ccctgtataa acagaagaaa 2801221 cctgaattgc aatctctgac agtttttctt ctggaagctg ttcttcaaat tgattcacat 2801281 aaatataact gtttcccagg ccgtgcattt tggtaaatcg aaatgagttc ataggtgcct 2801341 ccaacttttt ttctttttct tagtataaaa gctattataa gcggacacaa tacaattatc 2801401 ccccgttttt catacataaa agctccttgc actgacgcaa ggagctttta tcgtttatat 2801461 aaacatgccg gcaatggctg cgctgagcag attggctaat gttcctgcaa gaacagcctt 2801521 caggccgaga cgtgcgatat ctgaacggcg gctgggcgct aaaccgccaa gcgtaccaag 2801581 cataatcgca attgatgaaa aattggcgaa tccgcataac gcgaaactga taatggtagc 2801641 agttttctta gaaaactcgc cgatgtgcga accgaagtta gaataagcga caaactcatt 2801701 cagcaccaat ttctggccga tatagcttcc cgcctgcaat gcttcatgcc aaggcacgcc 2801761 aatcaaaaag gcgataggag aaaacacata gccgagaatg gattctaatg ttacgccttt 2801821 taaaccgaac aagccgaaag ccccgccgag aataccgttt actacagcga ttaacgcaac 2801881 aaacgcaagc agcatcgccc caacatttaa cgcaatttgc agtcctgttg acgctccctt 2801941 tgcagctgcg tcaatgacat tggctgcgcc ttcgccttca tccattttga aatcgctttt 2802001 tacggtttgc gttttttccg tttcgggtat aatcaattta ccaaagacta gtccagctgg 2802061 agcagccata aagctggccg ccagcaagta ctcaatcgga ataccgagaa gcgcgtaccc 2802121 aaacaaggta gatcccgcaa ctgccgatag accgctcgtc ataatcgtaa acaactcaga 2802181 gcgcgtcagc ccggcaatca ggggtttgat cactaacgga gattctgatt gtcctacaaa 2802241 aatattggca gcagccgcca gagattccgt tttgcttgtt ccaaggagct tcgacaatcc 2802301 gccgccaatg acacggaaaa cgagctgcat gattttcaaa tgatataaaa ctgcaatcag 2802361 tgctgagaag aaaatgataa cgggcagtac acttaatgca aatgccggac tgtctccgac 2802421 ctttagaagc ggtccaaaaa taaaactgat gccttcattc gcatagtcaa tcagaagctg 2802481 tacacggctt gaaaaccata aaaaaacagc gcgtcccgct tcccatttca acacgatgta 2802541 tccaaacgcc acctgtgtgc ataaaccaac gatgacggtt cttatcttaa tattgctttt 2802601 cttttctgaa aataaaaacg cgatagcaat gatcgcaact gcgcccagca gcccccacag 2802661 aacattcatg aatactcgta cacctcttaa attttattta aaaaaatatc ttttatacga 2802721 taacaataat attttttgat gtctacacat ttttttagtt cttttgtacg gcaaaataaa 2802781 aaagggcctg tccaggccct tttctttaaa acattggatt ttcttcaata aaggtatata 2802841 tattctcaac aagctcagca ggcgtttcac ccatgacgac ttctccgttt accagagcga 2802901 aaagcgattc catacatgtc ccgcagtagc ttaagcagcc atattcaagg acatcaaggt 2802961 tgggatcctt ctccaaaatc gcccgggctt cctgagagcc gtgagccaga ttgctgacac 2803021 aaaattcaat cattggattc atgcggtttc acctcacata tgtccattat cgcgaatttt 2803081 tcactattcg tcaaagacaa cggatgattc aaaatttatt atcgtaacat attatttctc 2803141 aaataacgtt ttactaattt gtgttttcag gctaaattgt aggttatttt gaaactatta 2803201 ttgtgatttt agatcaaatt cgatataatt ctagatgtta ttttacatag ttcgtatttt 2803261 cttcaatgta tctatcatac tcttcggatt aaaggggaat tcaaatgaaa aaattggtct 2803321 tgatcggcgg aggttacggg aacatgcgcg ttcttcatcg cttattgcca aaccagctgc 2803381 ctgatgatgt ttcaatcacg ttaattgaca gaaatcctta tcactgcttg aaaacagaat 2803441 attatgccct tgccgcaggc acaatttctg accatcatat cagagtgtca ttcccagagc 2803501 accctcgcct ggatgtccaa tacggtgata tcacatcaat tgatattgta caaaaacaag 2803561 tgctgttcca agatcgtgaa ccgatttctt acgatgacgc cataatcggg ctcggctgtg 2803621 aggataaata tcacaacgtg ccgggagcgc ctgaattcac ctacagtatt caaaccatcg 2803681 atcagtcccg cgaaacctac caaaagctga ataatctgag cgctaatgcc accgtcgcca 2803741 ttgtcggagc gggcttaagc ggcgttgagc ttgcaagtga attgagagaa agccgtgatg 2803801 acctgaacat tattttgttc gaccgcggta atctcatttt atcaagcttt cccgagcgtt 2803861 taagcaaata tgtgcaaaaa tggttcgaag agcacggtgt ccgcattatt aacagggcaa 2803921 atatcacaaa agtagaagaa ggcgttgtgt ataaccacga tgatccgatt tctgcagacg 2803981 ccatcgtgtg gacagccggc atccagccaa acaaagtcgt cagagactta gatgtggaga 2804041 aggacgcaca agggcgtatt gtattaacgc ctcatcataa tcttccaggt gatgaacatc 2804101 tgtacgttgt cggcgattgc gccagtcttc ctcatgcacc gagcgcccag ctggcagagg 2804161 ctcaagcaga gcagattgtc caaatcttgc aaaaacgctg gaatggagaa gccctgcctg 2804221 aatcaatgcc gcagtttaag ctgaaaggcg tcctcggttc actcggaaaa aaagccggct 2804281 tcgggcttgt tgctgaccgt ccgctgatcg gccgtgttcc gcgtatgctg aaatccggct 2804341 tgctgtggat gtataaacac cataacggtt aatgatagag aagaaccgct gatcaagtca 2804401 gcggttttct gtatacccat gcttctccat ttcctcataa acgtctttta attttggatt 2804461 gccttcaccg acaattttgt cttctacaag cacaagcgga taaaaatact cgtcatttct 2804521 gattttttcc gcaagctctt tcgcatgttc attgtcaggc ggctcatgaa tatcgatgta 2804581 ctgcatctca aaaggctgat ttggatattt tcttttcagc gcagcctcaa gccactcgta 2804641 tgtatccttg gctgtcggca tatttacaca gctcgcacaa acgttttctg ccccgtacac 2804701 gcttagcatg actggtttca tcacttgtag acgccccctt ctcctatgta agtcctttct 2804761 tttaagtata cagagcctaa gggcgttttt atagaaaaaa accgtttttg tgttgaagtc 2804821 tgaatgtgct ataataggga aagcaacttt gcaaaccaaa caatagattt ttattgttac 2804881 actgaatata atggttttat gacgacgaaa ggagcgaatg tcatgactga agttgaaatg 2804941 aaagaacagg tgcaggaagt actggacaaa cttcgtccgt ttttacttcg tgacggcggt 2805001 gactgtgagc ttgtagacgt agatgaaggt atcgttaagc ttcgtcttct aggcgcatgc 2805061 ggcagctgcc caagttcaac aattacgttg aaagccggaa ttgagcgcgc tcttcttgaa 2805121 gaagtgccgg gtgtcgttga agtagaacaa gtcttttaat aaagcagcca ggctgatatt 2805181 tgatcagcct ggctttttta ttagagatgt tgatcaaacc atgagctgat ataattcagg 2805241 cgcttgatcc gctgtcttgg gtgtccggtg cgtgataaat tgtgcgatgc attcggaaaa 2805301 cggacaagct tggtttcctt gcccattttt ttcagagcga taaacagctg ctccgcctgc 2805361 tcgatcgggc atcggtcatc ccgctcgcca tgcagtatca aaagcggtgt ctccacgttt 2805421 gctgcgtatt ttaaaggaga ccggtcccag agcttttctg tgtcctcaaa catgtcatgc 2805481 tcaagctgcc agtctgtaaa gaaatagccg atatcactga cgccgtgaaa gctgatccaa 2805541 tttgatatcg agcgctgggt aacggcagct ttaaagcggt tcgtctgccc gacgatccag 2805601 ttggtcataa aacctccgta gcttccgccc gtgacaccga gccgcttagg atcaatatgc 2805661 ggatctcgtt tgatagcctc atccacagcc tgcatcacat cgtcataatc ctttccccca 2805721 taatctcctc tgaccgcatt cacaaattcc tgcccgtagc cgtggcttcc tctcggattg 2805781 atataaacga ccgcgtatcc tttcgccgcc agcacctgaa actcatgaaa atatgtatgt 2805841 ccgtacatca tatgcggacc gccgtgtatg ttaagaataa gtggatatgt tgtctcacct 2805901 tccatttgtg caggcctcat cagccagccg ttcaccatca cgccgtcttc tgtagcatat 2805961 tgaatctctt caggtattga tatcgtatgc tccctgacaa acttgtcatt cgcgccagtc 2806021 agctgtttct cttcctgtcc aagcgggata ctgtaaagct cactcggtct gtccggcttt 2806081 gtcacactgg caataaagtg ctgttcatca ggtgaaagag aaaagctatt gatgtactct 2806141 ttttccagac gaatcggata cacaaggcct tcaatcgaaa tataatagat gcccgtactg 2806201 ccttgatctg tgccgatgac ataaaaccct tggctgtcct ttgtccaaat cgggcgctgt 2806261 tcagcaccac cgatcaatga atctccaatc agcgcatccg ctaaatgaac gtccagcatc 2806321 tcagtaagac atgtgaggcg gccttgttcg atatcataga gccacgcctt tgagagcgta 2806381 gcattcttat attccttttc atttccaagc aaagcaagat accttccgtc tggtgaaaat 2806441 gagcttgatc cgaatgagcc gcgatgaggt gtaacctgct taagatctcc agactccagt 2806501 gacattatgt aaacatcatg cggcttgctg gcatcatctg tttcagttaa attagctgag 2806561 aaaacaagcc atttgccgtc aggagaaaaa gcaggatcac catgatcagc tttgtgactt 2806621 gtcagctctt tcatctcacc cgactttacg ctgacaagca caagctgggc atacgcacct 2806681 ctcgtcagcc ctttgccgtc ccgtttgtag gagaggcctt gcacttcaac aggttcatag 2806741 ctgtcctgct ctgttttttc tcggtcatca atgctttccc cctctcccaa actgacagtg 2806801 accagaatcg attcaccgtc cggggaccat agcggctttg acacgccata tgggatatca 2806861 gtcagttttc ttgcttctcc gccttcagtg ctcatgatat aaagctgtgc cgcatcgcct 2806921 tctcgatcag aaataaaggc aagcgtgcgc ccgtccggag accatcttgg gtcggtgctt 2806981 cgcttttctc catgtgtcca aggaacagat cctcccgttt tcgtttcata gatccatata 2807041 tttgatgtat acgaatcttt ctcttgattt acttgtgatt ttacatatgc ggcacgggta 2807101 ccgtctgggg cgtattgagg atcggtcaca gagacaatcg ctgtgatgtc gtctgcggtt 2807161 atcagctttt tcatattcat ctcctccttt ttacatgtat ttcgtttttc taaataaaaa 2807221 ctcctttatc tccagcaaaa aaaagcgccc tccgctgacg ctgaggaacg cttggcatga 2807281 tctatacact ttttacttga tataaaggat ttcgctctat tatacttccc tctttcggaa 2807341 cggtcaaagc gtctacttca caatgaggga aatgaagcgc gagctgttct tttagctctt 2807401 ctccctttcc tttttcggtc atgacgagaa tcgttgggcc tgctccgctg agagccgttc 2807461 catatgcgcc cttcatctcg gcgacgtgct ctacttttga cagctcaggc acaagcatcg 2807521 cccggtacgg ctgatggaac atatccttct tcatgatttt cccgacaagc ggccaatcct 2807581 tggacatgat cgcagcaatg aggatattgc tgacagcact tgcttttacg gcatcggcat 2807641 atggaaactc cttcggaagc acgtctctcg cgtctcttgt cagcacttca taaaaaggaa 2807701 tgacaacgac tacgtcaatg tcagcattcg ggacgcggat catttgggtc tcgtcatcct 2807761 catgcaggcc gatcacaagt ccgccgacga gagaagcgcc agcattgtcc gggtgtcctt 2807821 cttctagact cgctaaatgc agcttgtccg cttcagacag ctttaagccg cataattcat 2807881 cagccagttc aatggccgct acaatcgctg cggcgctgct gccaaggccg cgtgcaagcg 2807941 ggatgtcgct ccacaccttc acatggacag gaggcatttc ttttccgtac aaatctgcgg 2808001 tccgtttagc cacttggtag atcaggttat ctgtacccgc cggaattccg gcgactgttt 2808061 ctgtttcagc ctcaaaagac catttgtcgc tttcaaagac ggtcagcttc aaatatctgc 2808121 tgagcgccat tccgactgaa tcaaagccgg ggcctaggtt agctgtgctt ccgggaacag 2808181 tgacagagaa cagcatgtcg gcttcgttca tacacgggcc gctcctttta catattcaag 2808241 gatgctgtct tcatcagtcg gcaatgtgac aggcttgatt tctgaaatgt cgaccgctgt 2808301 gttcggatct ttcagtccgt ttcctgttaa cacagctacg accttgctgc ctttcggaat 2808361 ttctccggat ttcacctgtt tcagcactcc tgcgatagac gcgcaagaac ctggttctgc 2808421 aaacacgcct tctacacggg cgatcagctg atatgcgtga aggatttcat catcagtgac 2808481 ttcgtcaatt ttcccattgg attcctcggc tgcctttaca gctttgtccc agcttgccgg 2808541 gtttccgata cgaatggctg tcgctattgt ttccggattt tcaatcactt cattgcgcac 2808601 gattgccgcc gcaccctcag cttcaaagcc gcgcattttc ggaaggcctg tgccgttttt 2808661 ctcatgatat tccttgaagc ccttccagta cgcagtgatg tttccagcat ttccgaccgg 2808721 gatcgctaaa acatcaggcg cttcccccag ctgttcgcac acttcgaagg cagcagtttt 2808781 ttggccttca atgcggtaag ggttgactga gttgacaagg gcaatcggtg atttctcaca 2808841 gatggaacgg acaattttaa gcgcatcgtc aaagtttccg tcaattgcga taatctcggc 2808901 tccgtacatg acagcttgag cgagttttcc aaatgcaatt tttccgttcg ggatgatgac 2808961 aatgcatttc atgttagcac gggctgcata tgctgccgca gcagcggaag tgttacctgt 2809021 tgacgcgcac ataatcgtgt cattgccttc ttcttttgcc tttgccacag ccataaccat 2809081 tccgcgatct ttaaatgatc ccgtaggatt gacgccttcc gttttgacat gaagctcaat 2809141 tccgagctgc tcagacagct tcggcaggtg aataagaggt gtgtttcctt catgtaaagt 2809201 tagcgccggt gtttgatctg ttacaggtaa aaattcttta tattgatgga taagtccttt 2809261 ccacattagc tccaaccgtt cccttctaca cgatatgtgc ttttgacttc ttgaacgact 2809321 tccaaatcat ttaggttttg caggatatca ctgaaatcag cttctgatgt atgatgtgtg 2809381 acaattacga tttcagctaa ctcatcatgg cctttaattg gcagctgaag gattttttca 2809441 aagctcacgc cccgctctga gaacacagat gtaattttcg agaatgaacc aacctcatct 2809501 tttacatgaa ttcttaaaaa ctgctgtgca taaatgtcag acggcgattt catgtttttc 2809561 tcatattgcg gtccgacaaa gctgttgccg gttacaccta ggcgcatatt tttcatgaca 2809621 gcgacgaggt cagaaacaac ggatgtcgct gtcggcatgc ttccggctcc cggcccgtag 2809681 aacatcgtct caccgacagc ctcgccgtat acataaacag cgttaaactc attatgaaca 2809741 gcagaaagcg gatgatggtc aggaagcagt gtcggctgta cgctgacctc gattttgctg 2809801 ccgtcacgct gagcaatccc gatcagcttc attgtatagc cgaggcgttt gctgaagctg 2809861 atgtcctcgt ctgtaatttg ggagatcccc tttactttga cgtcttccag atccacgttc 2809921 atcgagaagc cgaggcgcgc caatatcgcc attttccgtg cggcgtcaag cccttccacg 2809981 tcagaagtcg gatcagcttc ggcaaaaccg agatcctgcg cttccttgag cacttcctcg 2810041 tatgggcttt tctctttgat cattttggtt aagataaagt ttgttgtgcc gttcacaatt 2810101 cccatcattt ttgtaattcg atctgatgag aggccttcct ctaacgtgcg cagaatcgga 2810161 atcccgccgg caacactggc ttcaaagtag atatcgcatc cattttcctt cgcttcggca 2810221 agcagctcgg agccgtacac agccattaag tccttgtttg ctgtgacaac atgctttttc 2810281 gatctcagcg cgtcgaccaa atattgtttt gtctgttcaa cgccgccgat cacctcgatg 2810341 acgacatcaa catctggatc atcaatgaca tcatacactt ctgtcgtgag cacttccttc 2810401 ggcaaatcta cttctctctt tttctctaaa tcttttacaa gcactttttt tatcgtaacc 2810461 ggacagccga cctgatgcat aagcttatcc tgatggtctt gaataatttt aacgacaccg 2810521 cttccgacgg tacctaaacc taaaagccct acacgaatcg ctttcaaaaa aactccacct 2810581 ttcttttgat tgtcctcttg gaaaagacaa ttgttaactc aacacagaca tataagttac 2810641 aaacattata taagcccgct cctgttttga caagacatca ttaggctgaa ttttgcgaat 2810701 gtaaacgctt aacgcattga tatgacaaga ttctttattt tctaattatt tttgtcagat 2810761 tttctcctca ccttgagctg cctttgccga gccagctgac gcgtggaaca aacagcttct 2810821 gcgcccgcat attcatgaat tcctgcgctg tattgagaaa ttgttcataa cgcccacagt 2810881 cattaagaat gaagtcaagc tgttcttcaa aataatgctt ttctgattct gatgacatgt 2810941 aatagctttc tacgatttca aaataatgaa gcgggaaaag cagacggctg tataaaaggc 2811001 gtttcgaaaa tgaagacagc ggtgtgactt gctcgtattc ctgtaaaaag agaaagccct 2811061 gctgattaaa atcttgtctg tgatgcaaaa acgtatgcct catatattca gccaaatcac 2811121 gggaagcgtg gtcaaacacc caatccgccg gaatcctgat caatgattcc ggtgaccatg 2811181 tatgcctttc catccgctga tggcatatcg ttcctgaatc agcggcttgg ggcttgtcat 2811241 ccagctcagt gtccactaaa tattgtatcg cgttttctga cagtcctaaa taatatggaa 2811301 atgattcgat cattttttta tcgaatggct catgcggagg ggtctgaacc tttctctgcc 2811361 aaaatgcttc cagctgatca attcgttttc cccacagatc cttccactgg ccgattcttc 2811421 cggccgcctt cacctcatat ggatatcctc ggccttttcg gtgaaattcc gcaagctccg 2811481 ctccaatgga gaacgccctg tttgaataag ggggggccgc cttcagcaga gcgtacgttt 2811541 ttccctcatg ttcaaatgtc agttcacctt cttttgtaaa gataaaaacc gaaacgtatg 2811601 ggtcactttg ttcttgtaaa tactgactca tgtaataaag ctccgccagc tctgtttctg 2811661 agaattggga aacggggaca atcagaaagt atgaattagg cgtctgaaag cattgatatg 2811721 tgtgctggta catggaaagc tgcctgatgt gaatgccgta tttttctttt attgtacctt 2811781 tcaccatgat cacctgcctg ttgaattagg gctcatcaca tcgtagtcat acacagccgg 2811841 aattatgaat acatatttta atccgaagaa ggcgcaagaa aaagtcgtaa acttctcaag 2811901 cattttgtat aaactagtaa aaaagattgg gtgaagctga tgtcagaaaa cgaacaattc 2811961 agtcagatgg aagctaaagc aagagcacgg atgaaggagc gcggcgttga ggtatcagac 2812021 attgccgagc ttgtcttttt tctgcagaaa aaatatcatc cggatttaac cattgatgaa 2812081 tgcacgctga acgtcaatcg tgttctcgca aaacgcgagg tgcaaaacgc gattttaacg 2812141 ggcattgaat tggatgttct tgctgagcag aaaaaattgt ctgaaccgct gcaaacgatg 2812201 ctggaaatag atgaaagcct atatggagta gatgaagttc tggcattttc cattgtgaac 2812261 atttacggat cgatcgggtt tacgaactac ggttacatcg acaaagaaaa acccggaatc 2812321 cttaaacgat tgaatgataa atcaaccggt gaatgccata cctttttaga tgacatcgtc 2812381 ggagcgattt ccgccgcggc ttcaagcaga cttgctcacc gcgcgcggca tacagaataa 2812441 gggcaccctt ttagggcgcc cttttttcaa atgtatggaa tccattcagt cagagagtca 2812501 atggcgtgag tcggtttttc catatcgtct gtcatatgtt ctcttttcgt tacgcctgtg 2812561 tgaacgagca gcgtatccat acccgcgtta atgccggcca taatatcagt ggcgtagttg 2812621 tcgccgacca tgagtgtttc agacacatct gtgccgagaa cgcgcatcgc ctgctccata 2812681 ataattgatt ccggcttgcc gataaataca ggctgtacac ctgtagatac ggttaacacc 2812741 gatgtcagtg agccgtttcc cggcaggagc cctctttcag tcggaatcgc aatatctccg 2812801 ttagtggaaa taaagcgggc gccatttctg attgccaggc agccaacagc aaatttttcg 2812861 tatgtaatgg aacggtcgat gccaacaacg acaaaatccg cgttttctcc gccaaatgtc 2812921 aggccgtttt cttcaatcgc ctggcggatt ccttcctccc caatcacata cacagacgcg 2812981 tcttttttct gctgtgcaat gtgctgggca gttgccatgc tggtcgtgaa gacctgctct 2813041 tctgttgccg gaatatcaaa agacacgagc ttgtccgcta cctgcttcgg tgtgcgcgaa 2813101 gagttgtttg tcacgaaaag ataaggaacg ccgcgatctt tcagcgttct gacaaattca 2813161 cacgcctcct cgattttttc cgtgccattg tacatcgttc cgtctaaatc aattaaatac 2813221 cctttatatg ttttcatatc caacactcct gtggctttcc agttgttatt taaacgcgga 2813281 aacaggtcct agctctgttt ccaaatagct tctgatccgt ttcgggaagt cctgaagagc 2813341 tgtttgatgc gccttgatca gcctgtaaag ctcgccgctg tcagcgagca gatactgttg 2813401 aaccaacgtt ttgcggtagg cgatcaattt tttgagctca tcaccctctt tttccgtgac 2813461 aactttctca tcaacaagta tatccataat gtcgtcatag ctgcccgggt cccgcataat 2813521 aaagccgtca atcatgtcat tgcctgtatc caaaatgcat tcgattaaca gatggcctat 2813581 acgctgaagt gccaattccc cgatttcaga ctgccagtct gtttgtgagt caaatagcgc 2813641 cagctggtgc tcgaagaacc ctagtgtttt ttcgattttg cttctgtcaa caaaatacat 2813701 gacagcatcc cctttgtgta tatttatttt ctgatccgtt tcaagacaaa atacgcacag 2813761 ccgaaattgc agtattcgta aatatattca tctaatgtgc tgattttcgt ttcgaaggtt 2813821 gccttttgat tctggtcgtc aaagaagccc ttgagcctta actgaccgta tccccagtct 2813881 cccacaatat aatcgtattt atttaatata tcggagtagc gggctttaaa agcctcttcg 2813941 ttgaagccgt ctttgaaatt gtgcaccaat tcaaattcgg cattttgaat aagaatcatg 2814001 atctcacctc ttttttcact cattcctatc ataattcatt gccccgtccc catcaattgc 2814061 taaagaataa atcatgcgat ttggctaccc tacacatgag gagggattga taaatgaaac 2814121 gaaccgctgt cagcctctgc ctgctgaccg gactattatc cgggtgcgga ggcgcaggat 2814181 tggataatgc ccaaaatgtc cggaatcaga cgcagaatca aaccaaaccc attcatgtgt 2814241 cggaccgcaa cgaggctttt aacaggcata atgagaacga acaatttggc tatgtccgct 2814301 atcaaaaaga acaatttgac ggagaacagc agaaaacgcc ggtgatgaac cgggaagaaa 2814361 ccgctcacat gatatcaagt ttaacggttc agctccccca tattcaagat gctgcgacat 2814421 tggtgactga ccgagaagcg cttgtcgtat acaaaaccga ttctaaaaac cgggagctga 2814481 ccgccgatca ggtgaaaaaa acagcggctt ctgtgatacc gcgatactat cacgtgtata 2814541 tttccgataa tccaaaccat atgcaatccg tcgaaaatta cagcaatctc ggctctggtt 2814601 caagggatat tagagagatc atgtcgggga cgattcaaga aatgaaaacc tccccgcaag 2814661 gaagccctgt ctcagagaat gaaaatgcca atggagaaac gcgtcaggac atgaaaatcg 2814721 ataggaatga caaaaacgcc agatgatctg gcgttttggc attatgcttg tgcttgacgc 2814781 tttttagatg cttcgtttac ttgttcatcc gcatggtaag aggaacggac aagcggaccg 2814841 gcttcacaat ggctgaagcc tttttgcatc gcgatttctt ttaattctgc aaattcatca 2814901 ggatggtagt atttttggac tttcaagtgt ttcttcgtcg gctgcagata ttggccgatt 2814961 gccataatat ccacgttgtt cgccaagagg tcgtccatta cttcaataat ctcttctttt 2815021 gtttcgccga gtccgatcat gatacttgat tttgtcggaa tgtcaggctg catttccttc 2815081 gcacggcgca aaaattccaa tgaacggtcg tacgtcgcac gcgcgcggac tcttggcgtc 2815141 aggcggcgaa ccgtttcgat attgtgattc aggatgtctg ggcgtgtatc catcaaggtt 2815201 tttaggttat cgtagtttcc gcccatatca gacggcagca cctcaattgt tgtgaacggg 2815261 ctttttctgc ggatcgcacg gacagtttcc gcgaaaatgc ctgccccgcc atctttctga 2815321 tcgtcacgcg caacagccgt aatgaccgcg tgtttcaaat tcataagcgc gactgaatcc 2815381 gctacgcgtt ccggctcttg cagatcaagc tcagttggaa ggcctgtttt gacagcacag 2815441 aaacggcatg ctcttgtaca aacagaacct aaaatcataa atgtcgctgt acgtctgacc 2815501 gcccagcatt catgaatatt cggacacttt gcttcttcgc atacggtatg caggttgttt 2815561 tcccgcatga gttttttgag ccctgtatag ttttcatttg tatttaattt aattttaagc 2815621 cattcgggct ttctgaggtg ttcgtctttc tttgccaatt cccatcatct ccaatatcca 2815681 atatactcaa tttctgacac gaaacattct gaaaacgaga aaggtgcagg ttttagttct 2815741 gcaacaaaaa taatgttttt ctaactaaag aaagtctttt ctttagacac tttaacatag 2815801 gaaaaatttc tcgacaaggg aagatgatta ctgacatttt taagccgggt tgccgcaaac 2815861 tatgtgtatt caatatgaaa ggagattatt ttgtgaaagt tttgttatcc gctcttcttc 2815921 tccttttgtt tgcatttgag ccttctgcgt ctggaaaaaa actttcagat ccagtgctgt 2815981 cgaaacggat ggaattatat cataaaatcg aagctgtgac gcagatccct tggtatgcgc 2816041 tcgccgctgt tgatcaatac gaagaaaacg tgcggagcaa ccggaaagat ctgcctgaaa 2816101 aggcgggaat catcagcatc tatatacccg atgatatctg gagcgggcct gaaaacccga 2816161 atccgaaaga cgatgcgccg ttaagcatta aagtgtttga cggaatcgga atggatggcg 2816221 atggagacgg gaaagccgag gtcagcaacg atgaagatat cttgtatacg ttcagccaat 2816281 acttactgtc gtatggcaca gatgaagaca acatccggat cgggctttgg aattattacc 2816341 ggcgtgatca gacagtgggg attatatctg aattcatgaa gctgtttaaa gcctacggcc 2816401 atattgatct gggcgagcat gcattcccgc ttccgatcag aaccgattac agctaccgaa 2816461 gcacgtgggg agatgcccgc ggcttcggtg gaaggcggat tcatgaaggt acggatatct 2816521 ttgcccatta cggccttcct gtcaaatcca catgttacgg cgtagttgaa atgaagggct 2816581 ggaaccgctt cggaggatgg agaatcggca tcagggacat taacaatacg tatcattatt 2816641 ttgcccatct caatgggttt gccaaaggga ttaaaacagg acaaatcgtt gagcctggcc 2816701 aagtgatcgg atcagtcggc agctccggat acggcccgcc gggaaccgcc gggaagttcc 2816761 cgccgcatct gcactatggc atgtacaaag ataacggaag aaccgaatgg tcatttgatc 2816821 catacccgca tttgagggcg tgggagcgat atgaatacca aaaaaagaag taacaaaaag 2816881 ccgcctcttc aacaggcggc ttatttgctg cttttttctt tttttgaatc ggcaccgttt 2816941 tctttgctgc tcggaagctg gacagaaggc gtgacacccg agccgccgct tccattataa 2817001 aactgcggca cttcgccctg cactgcttta atcgatacag gaacattatt tgtgacgaca 2817061 gcggttttgc tggcaaatgg aatgatgacc ttcactttaa tttcgacaaa gatgctgata 2817121 tcaataagtg cgttatttat gccatacggc ttgattttgg ttttgacatc tgtaaaagcg 2817181 tcaccgatta aattgaaccg gaccgggatt ttcggcccga ggtttccaag aaggctgttg 2817241 ccggttacct gtcccagcgg aatgttgatc ataatgtttt cactggcgcc gctgtgtccg 2817301 gtatgggttt ccatctcttt caaatgagcc tgaagctgct ttgtcacttt tgttttcaca 2817361 ctgtttacaa cctgtgtatt aaaatcgatt gtcgttaagt ttccgttttc atcagaattc 2817421 atttgaaaca tatctttcat attttcactg tcagacatat agtcctcaat cgaatcctgg 2817481 atcacctctg tcgctatacg cttcgtttcc atctcgccga tgtccattaa aacaggtttg 2817541 atcgagccat tgatcatcca aaggctgacc gttgttgaca ggataaaaaa gacaacggac 2817601 aggagcatca cgtaacggaa aggcaaaggt cctctcttgc gaaaagggcc gcgatatctt 2817661 ggcaagaaaa tcccccctta catatcacaa tgtatgcttg taagagggga catagtaata 2817721 gccggggcca atttatttta tttcatcatt tttaaaagcg cttctctgcc gctcatgccg 2817781 actttgatgc caagatcttc cgcagcgtac gtgacggatt ctaaaggtgc gtctaacagc 2817841 tggtcaatgg tgcggacacc aactgcgcgt cccgccacga tgccgcgctc ctttaatttt 2817901 tcattcagca gcgccacatc aagcgcgccg cacataatgt atccgtgatc attggcgacg 2817961 gccataaaat tcgttttggg aagctttact gtcacagctg taaaaggctg tccttctatc 2818021 atgatcggtg tcaggtttac cacgtcaacc actcccttca ttcatcactt tatgatgaag 2818081 ggcacagctt gttgtgggct gactgcctta ttgtgcaagc ttccaagcaa gcagatcccg 2818141 caaaaattcc ggcataaaat attctttttc tgcagcgtcg cgaatcaacg gaaacagttt 2818201 gccgagcgta aacatatcaa gcaccgcaac ggagtattgt ttatgttttt caatatcttc 2818261 cccgttcagt gtgatccgag tgacgtgggt gatcccgtca tcgagccgtt tcgtttctac 2818321 ctcaacgccg gcatacacca ttttccccat cacttctccg cggaagccga gtcctttgat 2818381 ccggagctgc tccatttgtt cggaagcggc atggacaatg gtttccttca gttcttctcc 2818441 cgtcaggcgg acagccaccg ggttgatcgg atgcggacag atgcggtgca gatccagctt 2818501 tgtcacagga cctgctttta gcggaccgag aatgacacct gaattgacca tactgatgtc 2818561 cgtctcgcac cattccttta aggcgtatgc caaaagcaaa ggcagctctg attcttcaaa 2818621 ccacttcacc tcagcatctt gtgcaagctc tgcaacggca tcggacagtt tctcctcggc 2818681 ttcacgttct ttttcattga gaaacgcttt agtttctgcg gattctcctg tccattccgc 2818741 catgttctgc acagaagccg ttttgctgtt gatgcttcgc tgtacgctgt ccaccgtgat 2818801 ttctacacag ccgacataat gcccgtattt ctcggcgctg gccagcagta ccccattaac 2818861 cacttgtcca tcttcgagca aatgatgggt atgtgattcg aggattacat caatctcagg 2818921 caccgcttca gccactgctt gatcatcaag aatgcctaaa tgtgacagca gaacgataat 2818981 atcagcctgc cctttcactt ccagaatggt ttcctttatg ctttcaaggg catccgtaac 2819041 tgtccatccc agcttgtcat atacaggata atacggcaca gttacaccta agaaagcaat 2819101 ggacataccg tttttcaatg atttgatatg gtaaggcacc gcccaggacg gacggtttcc 2819161 atttttatca aacaggttag agacgatgac aggaaattca gcatgatcat ataaggcagc 2819221 aagctcttca tgcggaagcg taatcccttc gttattgccg atcgccgctc catcaatgtg 2819281 aaggcggttt aagagatcga cattcgcttt tccgaatgtc gcctctgtca cgaattgaaa 2819341 acgatcaaga tgatcgccaa tatcaaaaac gagcgtctct tcgccgtctg actgatgctc 2819401 ttttcttttc tgctcgatat aatctacaat tttcggccag ttttcaaaat ggctgtgcaa 2819461 atcatttgta tgatataagc ggagcttctc cttcataata tctctcccta atcgttcagc 2819521 tgaaaatgcc ttcataaatg agctggcagc cgatcaaaat caatacgatc cgcatgatca 2819581 taacgatcgt tttcgtctgc atttttctgt tgatggcggc gccaagcttt ccgccgaacc 2819641 aagcgccggg cacaagcgcg agggcgtaca gccaattgac gtgcccggaa atcatatgtg 2819701 aaacagaccc tgtcatagaa gacaggaaaa taataaacat ggacgttgcc accgcaacct 2819761 tcggcggaaa cagaaataac agcatcatcg ccggaaccat cagtgatccg ccgcctatac 2819821 cgaaaagtcc gcctaaaaaa ccgacaacaa aggcaatggc aataccgaca gaggcctgat 2819881 atgagtacgt ataaggctca ccggcatcat cctgaaatgt ccggataatt cctttgtgcg 2819941 ctttgttgat tggccgggct ttcgctttca gcattaagga taatgaaatc agaatcataa 2820001 aaatgccaaa ccaaacggaa aacgagtttg aattgaacag ctttgacacg taagccccga 2820061 tcatgctgcc gggacccgaa ccgataaaga aaatgagtcc gctcttataa tcaactgttt 2820121 tatatttaat ataagccaaa gttgaagaaa ggcccgtaaa aataatgacc aaaagcgaag 2820181 ttccaatcgc aacctgcggc gtcacatcct gaaacagctg cgtcactgtg cttaaaaaca 2820241 tcagagatgg cacaatgaca attccgccgc caagcccgat cagacttcct accgtacctg 2820301 cgattaatcc cagtacgacc aaaatcacaa acgacatcaa tcaaaacctc ttttctaaaa 2820361 taaatcgagc tgtctcggag caagtccgct gtactcgata tcaagcagtt caagcatctg 2820421 cttgccatta tccgcagcgt caccgccgga attgttgttg aacaggacaa aaacatcctt 2820481 acattgctgc tgcaattcat tcaggtgctt tttccaatcc tccagctcct gttggttgta 2820541 gcggtataag tacctgacct cccgccagtt tttcccgcca tcaggcttca tccagccctg 2820601 cttgttgcgt ccgtgaaacc tgacgagcgt tttgttttca tcggtcgcgc gcaacacggt 2820661 cggaacgctg ccttctccga tttgcggttc atcacagaca ctgtgaatcc agccttccgc 2820721 tttcataaat gaaagcgtct gctcataaaa tggcggcgag aaccaggaac ggtttctgaa 2820781 ttcaagcgcg caaggaatat ctcccatttg gtgcttacac catctcaaat aggcgacatt 2820841 ctccttcttg cagtcaaacc acggcggaaa ttgaaacagc accatggcga gcttattgct 2820901 atgtaaatat ggcgttaaag acaccttaaa cgcatcaaac atctcctctt ttgagtcaaa 2820961 gggaatttcg ccgcgctgat gccctgtcat gccctgatat gctttcacga taaattggaa 2821021 ggtttcgggc gtttccttca cccacttttc attattgcgc gccggctgaa tcgcgtaaaa 2821081 gctcgcgtct aattccacga tcggaaaatg ggaggaatag gcctgcaatt ttttctggct 2821141 ggccgttttc ggcggataga tgctgtcatg atccccccat cccgtcagtc cgatataaat 2821201 cacactcatt cacctctctt ccagtttatc acacgtgttt tcaggtttcc tcggaaatgc 2821261 tgttcatatg gcgggaaaat gcctcacgca aatgctgata ttgttcctca ttcgtatcta 2821321 aaaacgcctc ttctcttgag gaaggaatgt gctgatattc aataggcgcc tgaaactgct 2821381 cactcgtaaa atcgtacacc acaccattga tgctgttata aaaatgccag ctctcatcga 2821441 ctcttgtttt gaaaatcgtg ccgccgaaat ggtcttgaat caccaatgcc gtcacgccgc 2821501 attggccgca tgacgggcat tcttccgtcc atttagagct cgaatggcgc gaccaggatt 2821561 gcttaagtat gtatttgaca tgctccattg cctccgcctc ctttaaaaaa agataccacg 2821621 ttgatgagat tttaaaaact agaacggagg aaatcaaaaa acccggcggt aaaatccgcc 2821681 gggcttacga aggaacgacc agagctccgt caatttcagt gactttttcc ccatcattgt 2821741 acacgcaccg gcctttgctg taagtggccg aaatgctgca gggaaatgta tgtccttcgt 2821801 aaatgctttt tttatgcttt gcaaacatcg attctcttgt aacagtgtac ggctccatgc 2821861 tgacgagcac gaaatctgca tcacaccccg cctcaagccg cccttttttc tgaaggccga 2821921 atcgttttgc aggggccgcc gctgtccatt ctgcgatggt ttcaaatgga atctgatgct 2821981 caagcgccag ttccagcatt cctaataaag tgaactgccc gccgctgatt ccgccccatg 2822041 ataaaaacat gttatcctcc cgcttcaagg atggacggca aggggaatgg tctgaggaaa 2822101 ccatgtcaat gtccccggca atgagcgtct cgatcagcgt ctcttttgat tgccgtgacc 2822161 ggagcggagg cgcgcatttt gcgacagagc ccctttgccg taaatcgtca tggctgaaca 2822221 agacataatg cggacatgtt tcaaccgaaa catcaagacc ttcctgtttc gcctctctga 2822281 tcagccggac cgctttcgcc gtgctgatat ggacaaaatg aaccggacag cctgtcacct 2822341 tcgcatactg aatcgtgcga tacaccgctt caacttctgc ttcctccggg cgggaggcgg 2822401 cgtacgcatc cgcatccacc tttcctttat tggccaaaac catctgcaag tagcttgtga 2822461 tcgcgtcgct ttccgcgtgg agagcgagga tttttcctgc agccgcgatt tctgccatgc 2822521 ctttgagcaa tgtccgttca tcaacagagc ggaactcatc agtgcctgac tttgataaaa 2822581 acgctttaaa cccgatcgct cccgcttcag ccatcggacg gatgtcctcg atatggcctg 2822641 gcacaaggcc gccccatagc gcaaaatcca cggcagattt ttgcctgcct agctcagctt 2822701 ttgcgagaag atgctctgcc gtcacggttg atggaataca gttgagcggc atatcaaaat 2822761 aggtagtgca accgcctgcg gccatcattt gagaacctgt ttcaaacccc tcccaatcct 2822821 ccctgcccgg ttcattaaaa tgaacatggc aatctatcac accaggaaac acgtatttcc 2822881 cgtctgcctg gatgatttcc gtcccgcttg cttcaatgtc agaacctatc tcggcaatga 2822941 caccgttttg aactacaata tcagcttcta taacgccatc tggcgtaact gccttcgcac 2823001 cttttatcac catatcgtaa gccatattga tccccccatg tcaggatgac gattttccat 2823061 gtcagtttat gtaacacaac cagttctatt ttcaacagtt tactgctact atgatcgtat 2823121 tacatcagca aaaccgctag aattcctatt gaaaattatt caccttaacc aatgttttta 2823181 tagaaaagga gaatgcgcta tgaatattct tgatgtgatg aaaataccgg cttttgaaaa 2823241 cgccaattta atcgctggaa aagcaggagg ggaaagagag gttcagcatg tcaatatgat 2823301 ggacgctccg gatatcgtag actttttgca taagaatgaa ttgctcgtca ccaccgccta 2823361 tcacctgaag gatcacccgc atcaattatc tgaactgatt cggcaaatgg caaaacgcgg 2823421 ctgcgcgggc ctcggcatta aaacaaagcg ctatctggaa gatatcccga aggaaatcat 2823481 cgaactggcc gattcatatg cgtttccgat cattgagctt ccggaacaca tccgactcgg 2823541 cgatattgtg aatgccacac tcagccatat tctcgatatg cgttctaacg agctgcagca 2823601 agccatttac gcgcacaaaa aattcacaaa ccacattatg agcggcaagg ggctgcaatc 2823661 cctcctcaaa aaggtgtcag acatccttca gcttcccgtg ctgctgcttg accagcatgc 2823721 caaaatgctg tctgcgtctc atcagatttc agttgagacc gaaaagctga aaggcaccct 2823781 gaataccgta tccgggccat ttttcacttg tttctctaca atctcagatc agaaaacata 2823841 ttctgtcctg cctatttata atcacgaaaa aaactgcggc tacctgctga tacccgacat 2823901 ggtgcaggca ggcgacaaag gattgatcct cacgattgaa caagcggcca acgtcatttc 2823961 ctttgaactg ctgaaggaaa atgcgctgaa gcagttcagc cggcgggccc gcaatgagtt 2824021 tttcaacaat tttattgagc ggaccttttc ttcagatgac gaaatcaaaa accgggcgaa 2824081 agaattcaag ctgcgctggg atcaaaaata catgtgcatc gccggcaaac tcgatcgcaa 2824141 tgacgaatca atcagcttta cagaaaatca gctcgcttcc gacagcgtat tcgaatttct 2824201 tgaaggtgaa ttatcagcct tcccgtttcc acctcacttc tttatgaaag gaaatgtcgg 2824261 cattattcta atcgaggcga cagacagctg gagtgaaatg cacgcctcgg tgatcagctt 2824321 tttagaacag tttcaaacac aggtcagcgc tcaatttaaa cgaaccgtgt cctttggcat 2824381 cagcaatatc tgccaaaagc tcattgatgt tcccgacgct ttcacagaag cttctgatgc 2824441 tctgcaatcg gggcatttgt caagaagcac cgcatttatc caggtgtatc acgccaaaga 2824501 tgtgcctgag cttctgcgct tgctcccagt tgaggatttg aagaaatttt acaactccac 2824561 gcttcagagc ctcgctgaaa aacagcagga ggatcaaagc ctgcttcata cgctttccgt 2824621 ctatttagag acacactgcc aaatttcaga gacggcaaag cgtctgtacg ttcatcgcaa 2824681 tacggtcata taccgccttg aaaaatgcga agagcttctg gggaaaagct taaaagatcc 2824741 tgaaacaacg atgcgtttgc ggcttgcatt acgtatgcag cggctgatca gctaaagttt 2824801 gttacatttt cttacaaaac gaatcgtttt tcgtcacttt cagcaatcac acctgtcttt 2824861 ttcagctact gtatccaatg acacccctcg accggaacga tattatgtta ctaaagttca 2824921 catacaggga gggactatag tgaaaaaaag atcgtttaag gtgtttacac ttagcctgca 2824981 gcatgtgctc gccatgtatg caggtgcgat tttggtgccc ctgcttgtcg gcagggcgct 2825041 gaatgtaaca actgaacagc tgtcctacct attggcgatt gacctgttaa catgcggcgt 2825101 cgctacgctt ttgcaaacct tgcgcggaac atacatcggc atcgggcttc ccgtcatgct 2825161 tggcagttca tttgtggccg tcaccccaat gattgcaatc ggcagcaatt acggcattca 2825221 cgcgatttat ggttccatca ttgcggccgg tgtgttcatc tttttgtttg cgcgtttttt 2825281 cggcaagctg actgtgttat ttcctcctgt cgtaacaggt accgttgtga ccttgatcgg 2825341 cctttcactt gttccgacag gtgtgaaaaa tatggctggc ggcgaaaaaa taaacggcag 2825401 cgccaacccc gaatacggtt cgctcgaaaa ccttcttctc tctgtcggtg tccttgttct 2825461 gatcttagtc ctcaaccgct ttctcaaagg atttgcccga acactgtccg ttctgatcgg 2825521 catcgccgcc ggaacagcgg cagcagcgat catgggcaaa gtcagctttt cttctgttac 2825581 agaagcaccg ttcttccaaa tcccgaagcc tttttacttc ggagcccctg cgtttgaaat 2825641 cggtccgatc ttaacgatgc tgatcgtcgg aatcgtcatt attgtggaat caaccggcgt 2825701 tttttacgca atcggaaaga tatgcggcag acctttaact gacaaagatc tcgtcaaagg 2825761 ctatcgagcg gaaggaatcg ccattctcat cggcgggctg ttcaatgcct ttccttataa 2825821 tacctttgcg caaaacgccg gcttattgca gctgaccaaa gtgaaaacaa gaaacatcgt 2825881 cgttaccgca ggctgtatcc ttgtctgtct cggactgatt ccgaagattg ccgcccttgc 2825941 atctgccgtt cctgctgctg tacttggcgg cgcgaccgtc gtcatgttcg gcatggtgat 2826001 tgcctccggc gtcaaaatgc tcagcacagc ggatctcaaa aatcaatacc acctcctgac 2826061 catcgcatgc tcaatcgcac tcggcatcgg cgccagcacg gcccccggga tttttgctga 2826121 attccccgct ccgatccgga ttctggtcag tgacggcacc atcaccggaa gcctaaccgc 2826181 catctttttg aatctatttt tcagcttgcg cgacaaaaaa gaattaacag cacagcaaac 2826241 agaacttccg gtattagaac atacactcgc attagaaaaa gaggtgtaaa aaagatgaag 2826301 gaacagcaca atgccttaca gctaatgatg ctggggcttc agcacatgct tgccatgtat 2826361 gcgggagcca ttctcgttcc gttgatcgtc ggagcagcga tcgggctgaa tgcggggcag 2826421 ctgacgtatt taatcgcgat tgatttgttt atgtgcgggg cggcaactct tttgcagctc 2826481 tggagaaacc gatatttcgg catcggcctt cccgttgtgc tcggatgcac gtttaccgca 2826541 gtcggcccga tgatttccat cggaagcact tacggtgtcc cagcgatata tggtgccatt 2826601 atcgccgcag gactgattgt cgtcttagcc gcgggcttct tcgggaagct tgtccgtttt 2826661 tttccgcctg tcgtaaccgg atcagtcgtc atgatcatcg gcatcagcct gattccaacg 2826721 gcaatgaata acctggccgg aggtgaagga agcaaagaat tcggctcact cgacaacgtg 2826781 ctcctcgggt ttggcgtcac agcttttatc ttattgctgt tttatttctt taaaggcttt 2826841 atccgctcca tagcgatttt actcggtctt atcgcaggaa cagcggctgc atatttcatg 2826901 ggaaaggtcg atttttctga ggttttggag gcgtcttggc ttcatgttcc gtctctgttt 2826961 tatttcggac cgccaacctt tgagctgccg gctgttgtca cgatgcttct cgttgcaatt 2827021 gtcagcctcg ttgaatcgac aggcgtttat tttgccctcg ctgatatcac aaaccgcagg 2827081 ctgtcggaga aggatctgga aaaaggctac cgggcagaag gccttgcgat tttgctgggc 2827141 ggcttattta acgcgtttcc ctatacagct ttctcgcaga atgtcggcat cgttcagctc 2827201 tcaaagatga aaagtgtcaa cgtcatcgcc atcacaggaa tcatactggt cgcgatcggg 2827261 ctggttccaa aagcagcggc cctgacaaca gtgatcccca ccccagttct cggcggcgca 2827321 atgatcgtca tgttcggcat ggtcatttct tacgggatca aaatgctatc cagcgttgac 2827381 cttgattcgc aaggcaacct gctgattatc gcctcttccg tcagcttggg gcttggcgct 2827441 acaacagttc ccgcgttgtt ttcatctctt tcgggcgcgg cctctgtctt ggcaggaagc 2827501 ggaattgtga tcggcagttt gacggccatt gcactgcacg ctttttttca aaccaaacag 2827561 ccgaatagcg cagacataaa aacgtaaagg aagatgccaa tgttcacaat ggatgacctg 2827621 aaccaaatgg acacacaaac actgacagac acacttggct ctatttttga acactcttca 2827681 tggattgcgg agagatccgc agcactacgg ccgttttcgt ccctttctga tcttcaccgc 2827741 aaaatgactg gcattgtaaa agctgcggat cgcgagacac agcttgattt aatcaaaaag 2827801 catccccggc tcggaacaaa gaaaacaatg agcgatgact cggtacgaga gcagcagaac 2827861 gcagggctcg gcaaattaga acagcaggaa tacgaggagt ttctcatgct gaatgaacac 2827921 tattatgatc gcttcggctt tccttttatt ttagcggtga agggaaagac gaaacaggac 2827981 attcaccaag ccctgctggc aaggcttgag agcgaacgag aaacggagtt ccagcaggcc 2828041 cttatagaaa tttaccgaat cgcccgcttt cgtctggctg acatcatcac tgaaaaagga 2828101 gagacgcaaa tgaaaagaac catgtcttat ggcaaaggaa atgtatttgc ataccgaacg 2828161 tatttaaaac cgctcactgg agtgaagcaa atcccggaat catcttttgc cggaagagat 2828221 aataccgttg tcggcgttga tgtgacatgc gaaattggcg gagaagcctt cctgccatca 2828281 tttacagacg gagacaacac tctcgtcgtg gcaacggatt caatgaaaaa ctttatccag 2828341 cgccatctcg catcctatga aggaacgaca accgaggggt tcctacacta tgtagctcac 2828401 cgatttttag atacctattc tcatatggac acgatcactc tgactggcga agacattccg 2828461 tttgaagcaa tgcctgcata cgaggagaaa gagctcagca caagccgcct cgtcttcaga 2828521 agatcgcgta atgaacgaag ccgctctgtg ctgaaagcag aacgaagcgg gaataccata 2828581 acgattacag agcaatacag cgaaatcatg gatcttcagc tcgtcaaggt gagcggcaac 2828641 tccttcgtcg gcttcatccg ggacgaatat acgactctcc cggaagacgg caaccgcccg 2828701 ctgtttgtct atttaaacat cagctggcaa tatgaaaata caaatgactc atacgcttct 2828761 gatccagcac gctacgttgc ggctgaacaa gtccgcgact tagcgagcac cgtttttcac 2828821 gagctcgaaa ccccttcaat ccaaaaccta atctatcata tcggctgcag aatattagcg 2828881 aggttcccgc agctcactga tgtcagcttc caatctcaaa atcacacgtg ggatacggtt 2828941 gtcgaagaaa tcccgggctc aaaaggaaaa gtctacaccg aaccgcgccc gccatacggt 2829001 ttccaacatt ttaccgtgac aagagaagac gccgagaaag aaaaacagaa agccgctgaa 2829061 aaatgtcgga gcctgaaagc ctgatgggaa aactgacaac ccatatttta gatttaacct 2829121 gcggcaaacc agcggcgaac gtaaaaattg gattgaagcg gctgggcgaa agtattatga 2829181 aagaggtata cactaacaat gacggcaggg tcgatgtccc tctgctggct ggtgaagagc 2829241 tgatgtcagg agagtatgtg atggaatttc atgcaggaga ctattttgcg agtaaaaaca 2829301 tgaacgcagc cgatcagccg tttttaacca tcgtcaccgt ccgttttcag ctagcagatc 2829361 cagatgcaca ttatcatatc ccgctcttgc tgtcgccgtt tggttatcag gtgtataggg 2829421 ggagttaaga aggaagcccg cctcaccggc gggcttcttt ttgcacttca attaactttt 2829481 gatcctagga cagtacttga agtgatcccc acacttagtg aaacaacagc tagaataaac 2829541 attcacctat atttttcagg ataattgcct acgagaaaaa taccctgtag tcctttcatt 2829601 tataaatcga ggtttcaaac taataagtca gctcttagca gccgagctcc cttctccaat 2829661 cctataaaca gaccgcgttt tttctcgaaa aaatactctg aagacaattg ctgcgttttt 2829721 aatagttttg ataacgcgtt ctctcttaca cctttagaca aaatattcat tttttctttt 2829781 ttagacttaa atctatgtcg aaaataatcg ttggcatatc ttatcctatc tccactaaag 2829841 gaggtgacat tatgggattc tacaattctg gtggatacag tggaaactct ggttactcaa 2829901 acggtttcgg gagctccttc gctttgatcg tggtgctatt cattttgttg atcattgttg 2829961 gagcagctat ctttaattat taagtttaac tttccttgcc tccgccgtat ccaacacctc 2830021 cctgtccgac agacgccata agaagttttt atggcgtctt tgctatgtgt tcactaatct 2830081 ttttgtaatc cagaagctgt caagttctac gagatttatc gtgtgttttc ccacaacgct 2830141 tctgcgtctt gatcgcgctg tctgactgag gctaaaaaag tccggctttt aaaagccgga 2830201 ctcccgtcta cccccgttca actctcttct aatcctgcaa gctgaccgca taatcccgcc 2830261 atacccggta caccggcaca aattccccgc cagcccttct tctatatctt tgtcagaagg 2830321 ttgaggggtt tcccgaaaca atgctttaag cgcaatgatc attcccggcg tacagtagcc 2830381 gcattggaag ccgccttctt ccaggaaagc ggtttgacac atatccagct cttctttttg 2830441 aagcccctcg atggttgtga tggaatggcc gtctgcttga taggccatcg tcatgcacgc 2830501 attggccagt tttccgtcga ttaaaataga gcaggctccg cagcggccga ttccgcagga 2830561 cacctttgtc ccggtcagct gaaattcctt tctaagcagg tcactcagat gtgtcgtagg 2830621 aacggcagca acctcccacg cctgaccatt cacggtcatc cggaactgtt ccttttttac 2830681 aggaaatggc ccggcctctt ttatgtccat tgcttcagcc cctttctgtc gatcgcttca 2830741 agcaactctt ctcttgaaat tggcagcttg tttatccagc atccgaccgc atcatgtact 2830801 gcctttacaa tcgccggagt gatggcgatt gttccgattt caccaacacc gcgcggtcca 2830861 tatacgtctc ccttcattaa gtcttctatt gcaatcagct tcatgtcagg aacatctttg 2830921 attccgggaa tcaaatagtg atcgagattt tccgcagcat aacggccatc cgtcattttc 2830981 gcttcctcca tcagtgtgta gccgagtgcc atggcagcgc cgccttcaat ttgacctcga 2831041 tatccctgcg gactgacaac cggacctgcc gcaatagcgt gctcacaatc tatcaatttg 2831101 acatcgcctg ttaacagatc tacctccacc tcaacggcag ccgctccaaa tgagtagagg 2831161 aaatggccgc ccaccacagg atcaggcgtt gttggaaagt caaaggccgt ttcctctgcc 2831221 aaagggcctt tttcagccag ctccttatac gtcaccacga gcgcctttgt gtttttgtca 2831281 cgcaagcctg cagcgccggg aataagattt tccgctgaac agccgctcca ttctgccgcc 2831341 cgttttttca actgagctag aaacggcttc ttcaaacgct ggatcgcgtg ccacaccatg 2831401 cttgtgccgc gggatgctgt ggaggagcct gacttcggca cttttgcggt atccccaata 2831461 acaatggaaa tatcctctgc ggcacaaccc agctcctcca tgacaatctg ttcaatcgct 2831521 gctagaatcc cctgtccgca ttcttcaaat ccaaacgaag cagtgatttt gccttcactc 2831581 gaaagagaca aacggcctcc tgccgcatcc attcggccaa accccagccc gccgccgtgc 2831641 attgtaattg ccgctcccgt gcctctttgc agatacccgc agttccggct tgttttttta 2831701 agaatgggag atttagatat ggcattcaac acctgtgccg ctccgtcagt tggtgcaatt 2831761 cgatgctcaa gcggccccaa gtcatgcggt tttctgatat tttttcttct cagctcgagc 2831821 gggtcgatgc caagcatgcc gctgagacga tcgagatggg tttcgagtgc aaatgtgatt 2831881 tggttgccgc caaagccccg aaattccccc gccaccccgt tgttcgtaaa tactgatatt 2831941 ccttcagtcc ggatattcgg aatacggtac ggccccgcgg catgctcgac agaaaaatca 2832001 agaacagccg gtccgagcgt agcgtaagcg cctgtgtccg ccacaatttt cacgtcgtgc 2832061 gccaatagat ttcccgaatg atctgcaccc gtttttatcg taatcttcat cggatggcgc 2832121 ttaatgccag aacgtacaga ttcctttcgt gtctgatgaa ttttgacagg gcgtccgctt 2832181 ttcagggcca aaagcgcagc atacggctga atattcagct catccttccc tccgaacgag 2832241 ccgcccatcg gacttgacac aattctgatc ttctcttcag gaatatcaaa aatacgggca 2832301 agctggaaac ggtctttata gccgtgctgg gttcctgcat acatcgtaaa acccccgtcg 2832361 tcttccggaa cggctacacc tccctccgtt tccatatacg tatgcatctg ccgcggcagc 2832421 tcataggttt cttcaaagac tgtgtcagat gcttgaaacc cttcttccac atcaccgttt 2832481 gaaaaaaatg cgcggtgcag gatattcccg tcctcatgca gtctttgcgc attcggccga 2832541 agcgcttttt ctggtgaatc catgacttcc agctctttat actcaacttg aatcagctcc 2832601 agcgccgctt ccgcgatttc ttccgtttcc gcagcaactg cggcgatcgc atccccgaca 2832661 taccgcaccc tgtcctcaca taaaaccggc tgatcaggga tgacaatgcc aaatcggttt 2832721 aagccgggaa cgtctttatg tgtgacgacg gcctgcacgc cttccatttt ctcagctttt 2832781 atggtgcaaa ccgacacaat ctctgcatga ggataagcac ttctcagcac cttgccatac 2832841 agcattcctg gaaagctgag atcggtcata tatttcaatt cccctgtgac cttacccctt 2832901 ccatccggcc tgactcttga cggtttgttg atgatcattt attcccctcc ctcagccatc 2832961 agctctgcca tgatgacgtt ggcagcggct ttttttctgt atgccgctga cataaaaaca 2833021 tctgaggaaa acggcagctc atggataagt gttttgtaca gctcatgcgg gtcccaccct 2833081 ggtgccatcc atttcgcttc gctgtccaat aatctcctag gagtgatatc ggcatggcca 2833141 gcggcgaggc gaatgctgcc gtctttcaaa aaacgtccag ctgcaacagc agccgctccg 2833201 gtaaaagcct ggcgccttcc aagcttgtga taaaatacac gctctccctc cgcccgcggg 2833261 atgatgacac gcgtgacgat agccgttcta aagtcttcct cactgagcca agcgccaagc 2833321 ggcagcctga ttagctcctt ttgatatacg ataagctcag caccaagcac aagcagaagc 2833381 ggaatgaaat caccgatttt actcgctatg ttgccgccaa tcgtggcacg gctgcgaatc 2833441 cccggtgcag cgacagcgga agcagcgtca ctgaaacagc taagcgctct cttaatcaaa 2833501 gggttctttc tgcattcatt cagtgatgtg agccccccga tcgacacgtg ggtgtcactg 2833561 gtgctgatcc ctcgcatttc gtcaatccct tcaaggctga caaggtgctg tttcggtaga 2833621 gttcctttgt cccactgaag ctgaaggagc gtgcttcccg atgcggcaca cacatccgga 2833681 gcaagcttct ctaaaagcga ataggcctca tcaagcgctg ccggtctcca taattgaata 2833741 ttcatccttg cttttgtcac ttggccgttc aagacatcgc cctccttacc atgtcatatt 2833801 cctcgggtgt atcaatatcg tccaactcac cgctatcctt tgcctccaaa accgctcctg 2833861 ctccaagctg tccgcttttc aggagcctgc gagccccttc atctcccttt aatcccttta 2833921 cataaggaaa acatgtcgac gagaagtaga ttggcggggt gaacgcccct aaaaacgatg 2833981 acacggcaaa tgactcagga gccagagcca caagggcatt gagatgatcg acggaaagct 2834041 gaggctggtc ggctaacaaa atgacaatgc cgtccgcccc catgctttct gcttttctca 2834101 ccccgctgct gactgaatgc ccctgaccct tttctgcgtc ttggcaaacg tgcaggctcc 2834161 agcgtttttg aaaaggcgga gcgtgatacg gcgctcctat ccactcaagg gaggcatgtt 2834221 ctgtccgctc gacgaccagc acgtgatcaa ggcgggacga cagagcagtt ttcaaggaaa 2834281 gtgagcctat gttttctcct tttagcggca aagccagctt gttttgtccc attcttctgc 2834341 ttttgccggc agcgagaaac acgccgatca gataggggct tctcatacaa ccgccacccg 2834401 ttttcttgtt tgaatgattt ctgcaactac acttaccgca atttcctcgg gaccttccgc 2834461 accgattttc agcccgaccg gactgtaaaa gtgagacgga ggatgttttc cgctcagcag 2834521 ccgtttcgtg cggtttgccg aacccaacag tccaatataa tggaggtttt gagaaaataa 2834581 gaagttgatg atcgtttgat cgtgctgata atgatgggtt gccacaacag ctgcatcatg 2834641 cggaaaaaat tgaaattcgc taagcatttg ttccggaaaa gcggtgatca gctgatccgc 2834701 ttttggaaaa agagaggatg tacaataagc gggccgccaa tccgtcacga taacagaaaa 2834761 ccctgtgtca gccgccaaat tggccagcgg tacattatcc ggtcccgccc caaacagaat 2834821 gagacgcggc ttcggttcaa ttcgctgaat aaacatgtta gtggtttgat cgaaatgcgg 2834881 taaatgaagc gttgaaacag tacgttgaat atcttgcaga ggcgcgtccg gccagttccc 2834941 aaaatgtccg ttctccgtca gaaataaata atgggaggat tcaatcttta taacggaagt 2835001 gacagctttg cctgaatgaa ggcagtccct cactttctca tagtgccgcc ttttttcctg 2835061 agtgattcgc tctgcatgaa catgaataat gccattgcac ccggctccca tgccccaaga 2835121 aagatcgtcc tccgaccgca tgtcgtaggg aatcagcgtt gatgtgagct gatcgcccag 2835181 cgcactgatt ctttggaata catcttcttc cacacacccg ccgctcagca agccaatccg 2835241 tctgcctttt ttcttaaaga gcatagaggc gcctgctttt cgatacgcgg agccttcaac 2835301 ttgaacaatt gtcgccagta cagcctcctc ctggtcttcc aggagcgcat ctaacatcgt 2835361 gtgaaaattc cccaatgccg catcctcctc tcgaaaattg ccgtgagaaa caactagttc 2835421 agcgtgattt tataggtaac ttgtataaag aatagacgat ggaagaaaaa atgactcatg 2835481 atttgtcaga aaatgaaaca catagaaaga ggatttgtaa aaagagtcaa acgaagaaaa 2835541 tcagattgga gaaaacacga aatcatatcg ttaaaaagct tgcggagttc cgcaagcttt 2835601 tctttacacc gctgcctggc ggccagcgtt ttcatacaca tccagcgctg cttggagcgc 2835661 ttttcctgct tcgattcctg cgttatgtct gagaagcaca gcctctaacc cggcaagcac 2835721 gaatagcacg ttttcttttc tgcagctgta ccccatcgtg ccgatcctcc agatcttccc 2835781 tgcaagcggg ccgaatgagc tggcgatttc aatgccgaat tgtgccagca gcatgtcacg 2835841 gacagactcg ccgtcaatgc cgccgggaat ttcgacacag gtgacaacag gcattttgca 2835901 gctgtcatct ccaaacaatc ttagccccat tgcctttatc cctgctgcta atgcggcttc 2835961 atggtgccga tgccgctcga aacgcgtctc aagaccttct tcaagcacca gtctgactcc 2836021 ctcacgtaag gcgtacagca tcgtcgtcgc ttctgtatga tgattgagcc gtctttcgct 2836081 ccaataatcc tcaagctggc tcaaatcaaa gtagttgctt gtaattggcc gatttcccga 2836141 aagtgctgcc ctgtcagctt gtgtcgcaat cccgcgttcc acctttttgc gagctgcaat 2836201 cacgtccgcc acccgctcat tatatgtaat cggcgccatt cctgaaggca cagacaaaca 2836261 tttttgcgtt ccgccgatgg cagcgtcaat cttccattca tcgactttaa cctcgcagcc 2836321 cccaatcgtt gcgactgcat cgacgataaa caatgcatcc tcggtgcggc aggcttcgcc 2836381 gatggctttc agcgggtgaa tccgtcctgt cgatgtttct ccatgcacca tggccacaat 2836441 tttcggcttc acttttttta tctcccgtat gatgtcctcc gggtcaaaaa ccgttcccca 2836501 ttcgcactcc agcatatgaa catttgcccc atatcgctcg gcgatttcag tcagcaaata 2836561 accgaaacgg ccgtaaatgg gaatgagcac atcatcttcc ggctctatca cactagccag 2836621 cactgcttca attcccgccc gtgaagtgcc gtcaatcggg tatgcccagc ggttttttgt 2836681 ttggaacagc tcccgaagca tctccatcgt ttcattcata atacctgtaa acgccggatc 2836741 aaattggccg acaaccgggg tgctcattac tcttaataca cgcggatcaa cctcaacagg 2836801 ccccggtgtc ataatcgttc ttaacggggt gcataattct cttctgcctg acacagccat 2836861 tcctccttta tcagtaagcc agtttgtata ataaatcagt cagtgcgcgg acgccgatct 2836921 caagctgtct ggctgacgta tattccttcg gtgagtggct gacgccgcct cggctcggca 2836981 caaacagcat acaagcagga tagcgccttc cgatcatttg cgcgtcatgc cctgctccgc 2837041 tcaccatttc ctcacagctg aagccgtttt ctaatgctgt ttcaaaagcc gcagccttca 2837101 gcctttcgtc catcggcaca ggctctatcc gcatatattc atcaatcaca gcgcgaattc 2837161 ctttttgtag gcaaatgccg ttgatcaaag caaccatgtc ttgatgaaac tgttccagca 2837221 catgctgatg ctgatggcga atatcgattg aaaactggac gcggcccggt atgacattgg 2837281 ctacattggg ctctgccgtt atttttccgc atgtcagacg gagctcatcc ggcagctcat 2837341 ccgaccgcag cagcagctca tgaatgatac ggctgctggc tgcgagcggg tccttgcgcc 2837401 atttcatgga ggtggttcct gcgtgattgc attctccttc gagcgtgacg agatatcgtc 2837461 tctgccccgc aatacttgtc acgatgccga gatcccggcc tgacatttcc aacgtcttcc 2837521 cctgttcaat atgcagctca acaaacgcgc tgatatctgt cctatatgct gactgaaaca 2837581 cacctttgcc aaaaccgctc tcatgcatcg ctgtttggag ggagactccc gactcgtctc 2837641 ttggctcttt tgcatcttgt tctgaaaaaa cacccgtcat attccccgac ccccaatagg 2837701 tcattggaaa acggctgcct tcctcctcac ataaggagac cgcctcgagc gttttttttg 2837761 gcgctccgta tgtttccttg agctgcttta acgcgagcat tgccgccaga acgccatagg 2837821 cgccgtcgta ttttcctcca ttgatgacag tatcgatatg tgaaccggtt acaatgactt 2837881 catccggaga ctgggtgccc gaaagccttc caaacacatt gccgacatcg tcgaatcttg 2837941 tttcaagccc gaaagaagac atttccgttt tcacagcaag ctgtgcgtcc atccactctt 2838001 ttgtgtataa aagcctcgtt acgccgccat ccgcagacgc accgtattgg gcgagccatt 2838061 caatataatc tgtgatgctg ttttttactg aaagcttctg cttttccatg tactcccccc 2838121 tctggccgct atggtgactt cattatagaa ggagcaacat gatagttcat tgacagatta 2838181 accaaaaaaa cgtttatttt ttagccacag tatccatcca gcaaccagat acaccctaca 2838241 tgtcacaact attttgatgt aaaggtcaaa agaaaacacg gtaaggaaga gagccagcaa 2838301 gagcgaaaga gagggtcaaa atgcctttca tatgaacaag ctaagctgga gaggcgatgt 2838361 tcgcggaacg gatgaaaaca gaaatgccgg cagcccgcaa aaacaggacc taaagatatg 2838421 gaaacaggag atttccgcct cctccaaagg gactaattta caattttaat gaaaaatata 2838481 caaaatgaca cttctatcct ttatttcaat tttagataat agatatgatc tgataaaagg 2838541 agggcaagtg atgacaaaaa aagcatggtt tctgccgctc gtctgtgtat tactgatttc 2838601 cggatggctt gcgccagcag cttcagcaag cgcgcaaacc acattaagcc ttaatgaccg 2838661 attggcgtct tccccttcag gaacgggaag ccttctctca ttagccgccc ccgctgcacc 2838721 ctatgctgac acagatacct attatgaagg ggctgaaggt aaaacaggag actcgctaaa 2838781 aagcaccctg caccgtatta tcagcggaca cacgatgctg tcctacagcg aagtgtggaa 2838841 cgcgctgaaa gaaacggatg aagacccaag aaatccgaat aacgtcatcc tgctctatac 2838901 gaatgaatcg cgttccaaaa acctgaacgg cggcaatgtc ggcgattgga accgcgagca 2838961 tgtctgggcg aaatcccatg gcgattttgg tacgagcaag ggacctggta ctgatattca 2839021 tcatttgcgc ccggctgatg ttcaagttaa cagcgccaga ggaaatatgg attttgacaa 2839081 tggcggcact gaatatgcga aggcacccgg aaattattat gacggcgatt catgggagcc 2839141 ccgcgatgat gtgaaaggcg atgttgcccg catgctgttt tacatggctg tccgttacga 2839201 gggtgatgac ggctatcctg atcttgagct taatgataag acaggcaacg gctcagctcc 2839261 ttatcatggc aaacaatctg tcctgctcga atggaataag caggatccgg ttgacgaccg 2839321 cgagcggaaa agaaatgaaa tcatttatga aaaatatcag cacaaccgca atccatttat 2839381 cgaccaccct gaatgggcgg atgagatttg gccgtaagaa aaaggtgctc cttttgagga 2839441 gcaccttttt ctaatacaca gcctcttccg tttccgcatc gaaaaagacg acgtggtcca 2839501 ttttcactga gagctggatt gaatcgcctg catcgattcg cgtgtttccg tccaggcgga 2839561 ccttgagccg ctcgtcccca gccatgacat gcactatgag ctccgagccc agattttcat 2839621 tcacttccac gttcgcttga aacactgaat caaacaactg gtcatttcct gtcatttgtg 2839681 tgatgtgctc cggccgtaca ccggcaatca tctgttctcc ggcatatccc ttttccttca 2839741 gccgctttgc tttttcttca ggaatatgaa gccggatcga agaatttgtg aaaaacagct 2839801 cgccatgctg ctgttctatg atgcctttca aaaagttcat tccgggagag ccaatgaagc 2839861 ctgcgacaaa caaattggcc gggtaatgat aaatgtcatg aggtttcgcc acttgctgaa 2839921 tttccccttc attcatgacg acaatccgat ctcccattgt cattgcttcg gtctggtcat 2839981 gcgtgacata aatgatcgtt gcctctaatc gctggtgcag cttgctgatt tctgtccgca 2840041 tcgtcactct tagttttgca tccagattag aaagcggctc gtccattaaa aagaccttcg 2840101 gctccctcac aatcgacctg ccaagcgcca ccctttgccg ctgcccgccg gagagcgcct 2840161 tcggttttct cttcagcaaa tgttcaattt ctaaaattct ggctgccgca tgaacccgct 2840221 cggcaatttc ctgtttcgcc atctttctga gctttaatcc aaacgccata ttatcaaaaa 2840281 ccgtcatatg cggataaagc gcatagttct ggaataccat cgcaatatca cgttctttcg 2840341 gcggaagatc attgacccgc tccccatcaa taagaagatt tccttcagaa atgctttcta 2840401 atccagccac catccgcagc gttgttgatt ttccgcatcc tgacggcccc accagcacca 2840461 aaagctcctt atcctttaca tctaaatcaa agtccttcac ggttaattgt gagtgatatg 2840521 attttttgac gtgttcaaat gttaatgaag ccatcagaaa agtcccccta tcttttgacc 2840581 cgttatttcg tcactggaaa caacttggtc tttctgttat ttttagagta atcgattccc 2840641 atttttgcta tatttctaaa ataaaaaatg taaatttgta ttataacgtc ataatacatt 2840701 ataatataaa taataggtta aaaggaggct accctttgtt aaacaacgga agttctacac 2840761 ctttatacat tcagctaaaa caaatcatca ctgatgacat caaaaagggc gtgtattccc 2840821 caaccgccaa gctgcctacc gaaaacgagc tttgcaccaa gtataacgtc agccgcatca 2840881 ccgtcaggaa agccattctc gatttagtcg aagaaggcta tctgatcagg cagcagggaa 2840941 agggaacgtt cgttaaaagc cctaaattaa aacgagagct gatcgctgta aacggctact 2841001 cggaatttat ggaatcaacc ggcaaaaaac cgaagcatca tgtgctgtcc catgacatca 2841061 ttccagcgtc aaaacccatc gccgaaaagc ttcaaatcca acccgagagc cctgtggttg 2841121 aattaaaacg gattttatat aatgatgatc agcctctcac ctttgaagtg acgcattatc 2841181 cgcttgattt gtttcccggc attgatacct ttattgctga cggcgtctcc atgcatgata 2841241 ttttgaaaca gcaatacaaa gttgtaccca cgcacaatac gaagctatta aacgttgtat 2841301 atgcccaaca ggaggaaagc aaatacctgg attgtgatat cggggatgcg ctgtttgaaa 2841361 ttgataaaac ggcttttaca tcaaacgacc agccaatcta ttgctcattg tttttgatgc 2841421 acacaaaccg tgtcactttt accatcaaca gcccctacac ataacaggca taaaaaacga 2841481 gacactgctt atagtattct cgttttttca ctgcttcccc cgtcctccaa gcgataagga 2841541 tagccatagc cgaaagctcc gtacacaccg caagttttcg cagccgtttc agcagcctgg 2841601 cgcaaagcat acgttatatc ctgcttcacg caaaaggcag tcaaaaagcc tgctataaaa 2841661 gaatctcccg ctccaagtgt atctattata tcagcttcca caatcggctg atgatagact 2841721 cgatcacccg cagacaggat tgctccttgg ccccctcggg tcatacaaac cattttggct 2841781 ccgtacccat gagctgtttt ggcaagctca ccgcattccg actcactcaa atcgcttcct 2841841 gaaaaaaacg catacgtcac ataaggacag accctcctca aataatcatc ctcccgattg 2841901 gttgaaaaat caaatgagac cgggaccagc ccgcacagct gcggaagatc gttctcaagc 2841961 ctgctgtaca cgctcgtatg cagcagatca tgcccgctga taaaagatac atctttctcc 2842021 tgaaacgcga ggcgaagccg ggactgaatg ccgcctttat ttgatctgac aaaaatgcgg 2842081 tccccctgtt catcaagggt gacaatcgcc atcccgtttt ctccgtgcgc ctggcggata 2842141 taatctgcat tgacctgctc cagcttgaga acgttcaaca gatgcgccgc ggcttcgtca 2842201 ttgccgacga ttccgatata ggaagactca tgcccgagcc gcttggcaag cacagcaacg 2842261 tttaaggcat ttcctcccgg gtaaaatgtt tcttgatcct ggtagtaatc tacaacatta 2842321 tctccaaccg caatcaattt catagcgctt cctcctttat ccttttacac tgccgcttgc 2842381 aatcccgcgg acaaaatatt tctgcatcaa taaaaataga ataataatcg gcgcggctga 2842441 aatcgttaac cccgccagca ggacgcccca gtctgtctgc agcgcgtctc tgaactgcat 2842501 cagcccggct ggaatggtcc gtaaattctc atcatctatg aaaataatcg caaacataaa 2842561 ctcattccat gtatggtaag ccgtcaaaat gccggatgtc accaaaatcg gcacgctcat 2842621 tggtaagaaa attctgaaaa atactccaaa acttgtacac ccatccaaat aggccgcctc 2842681 ctccaattct tttgaaatag aaagaaaata agagcggatc aaaatgatgg tgaatgggat 2842741 ccgataagcc gcatacggca agattaacgc ccaatacgta ttgtacaggc ccagcgactg 2842801 aataatagaa taaagcggca caagactgac ctgcggcgtc agcatcaatc cgccaagaca 2842861 tagcaccaaa aagaatcctt ttcctttaaa ctcaaaccgg gaaaggccat acgctgccca 2842921 tgcactgata aagacagtga tcacacacgt cagcgccgta acgatgacac tgttcataaa 2842981 ataagaagaa atcccctgat tccaggcgga aacaaaattt tccggatgcc acgaagacgg 2843041 cagcgaccag ctgtgctcaa aaatatcgtc agagttttta aaggcgctca tcaccatcca 2843101 gagaagcgga taggcaatcg caatcagata aagaaacaga aaaacccaca cagacgtttc 2843161 tccgatatac cattttcgtc taggcttatc tttcacctca atgtgctggt caggcaccgg 2843221 ctccaatctg aacgaatctg tcttcttctg aggcagcatc agttactcct cctttccggt 2843281 tttaaagaac ttcatttgca tgagcgataa tgcaagcgta atgattaaca cgacagtggc 2843341 aatcgctgag gcgtagccca tcatatcctt tgtaaaggcg cttttatata aaaacgtgct 2843401 caagacttct gacgcttttc ccggcccgcc gcctgtcaaa atgtacggct cattaaagac 2843461 cgtaaaggct ccggtcagcg tcatgaccac cgcaacaaaa gacatctctt tcgtctgggg 2843521 aacagtaata tgaaaaaact gctgaatttt acccgcgccg tcaagccggg ccgcttcata 2843581 cagttcatcc ggtatttttt gaatcgacac gatgtacagc atcgcaatat aaccgacaga 2843641 ttgccactgg gacacaaaaa tgacagaaag catagctgtg ctgtcatccc cgagccaggc 2843701 cctcgtcagc tgatcaagac cgatggcctg aagcagctga ttcaaaagcc ctgtctccgg 2843761 attgtaaata aaatcaaaca aaagcgcgat caccgtcatt gagatgacaa ccggcaaaaa 2843821 gaaaacggta cgaaaaaacg gcgaccattt tctgaccagc ttatcctcaa gcaccgccgc 2843881 caaaatcaaa ccgccaaata cctggcatac aattgagatc actgcataaa gcacattatt 2843941 ggtaagtgcc tgatagaaga caggatcatg aaataattca acatagtttt ttaagccgat 2844001 aaacgttttt tccggagaaa atgagctcca ctgaaacagg ctgaggaata cattctcaaa 2844061 aatcgggata taaacgaaaa gtaaaaaaac gagagcgggc accaaaaaca aataggggat 2844121 tattttattc tgattgacca agggtatctc atctccttta taaaaagaaa aggtgcgaag 2844181 cttcaccttt tctttgattt attcagctga cgccctcacc tgctttgctg ccttttgaac 2844241 ggctttcatc acctgctgcg gtgtcatgtc gccgccaagc atttgctgga cgcccgttag 2844301 gtacgcatct gcgacttcaa catcgacatc catatcaaac catggaacca ttgatttggc 2844361 atcaacaata tgctgaacgg cttcacgctg aatggctgtt gcattttctt cagtagccgt 2844421 accttgcact gcactgtatt tcccgacatc tttcacgagc ttttcgccca ttcttttcga 2844481 cgtcaagaac tgcaaaaatt ccatcgcttc cttcggatgt tttgttcttg aggagatcat 2844541 gaatccttcc ggcgctcccg ttaacgcttc tgaagatcct ttctgcccgc tgatttcagg 2844601 aaatgggaac atcccgagat taaccggttc aaccagcttg atttccgctg tttccgcata 2844661 tatcatcgcc gactttccgc tcttaaattg ctgtctcaca tattcgtggt cgacggagtt 2844721 tacatgttta ttaaagtaag gcatcagctc ttgaagcttt tcaagtgctt ttacgtagcc 2844781 ttcatcagta aattcacccg ttttggcgtt atagtccttt tcccgtgttt tttcatcgac 2844841 catccgctga ttaagcgtgc cgatatagtg cgagattgtc caagtcgcct ttgttccaaa 2844901 gctgatcggt gtgtagccat gttctttcag cttttttgac acatcgatta attcatccca 2844961 cgtcttcggg ggatcaagat tcagcttttg gaaaatgtct ttattataga agaatgattt 2845021 agcgtccatt tgccacggta cgccatattg cttgttttca taagtaaatg gtgtaatttg 2845081 cgattgaacg agctgtgatg accaatcggt gtcatttttg tagtaggacg agagatcaag 2845141 tgctttattg cctctgataa atttaaaagc aaactcatcg ctccaagaga agtaaatgtc 2845201 aggagggctg gtggttccca gcatgacctt aattttatct ttataggagt catttaaaac 2845261 ggcttcaatt tgaatgtcga tatctgggtg atctttttca aattccttaa caacctcttc 2845321 aaaataactt ttttccggct cctttggcca tctgtggaaa aatttcaatg tcacctttcc 2845381 gtccgctgaa ctgctttggc tcgaacagcc tgcgatggtg agcatactga cagctgcaat 2845441 gatcaagaac aacaacattt tcttcaaagg gttggcctcc tctggacatt agactataat 2845501 gttatataac attatagtct aatgcataat ggttcttcat tttcagatca atactcaact 2845561 ttccacatgt atcttctatg agataaagga tgatttctct cctctgccag ctcgtctgca 2845621 tagcttctca gcacacgatt gagaacgagc ggagcaagat agcctttaac tgaatcgtca 2845681 attgcagtga agtcgtaaga tgcagcatca agcacagtga gctttttgcc atactttttc 2845741 gagaaggtaa gcgcccgctc ttcaagaggt cttgtttcat ctaaaccgag caggatgata 2845801 aacggcacgg attcatcaat aatttcaaac ggtccgtgaa aatattctcc ggcatgaatg 2845861 gcgtgggaat gaatccattg catttccatg agaatgcaga tgctgtagga gtaagcgaca 2845921 ccgtagtttg caccgcttgc catggtataa ataatgcttt ctttttcatg ggcttttgca 2845981 aattgcttgg cgttgtcagc ttcctgctta agggcttttt catatacagc ctgcaattga 2846041 tctaagcctt caattgcttg ctcaaatttc gtattgtttt ctaatacttg cagggttcca 2846101 aaaacgattt gatacaaaac gccatagttt gtattgatcg caagcgcctc atcaccccaa 2846161 tcgtactggg caacatattg cgcttcctgc gctaaaggag actccggttt aaacgtcatc 2846221 gcaatcgtaa gtgcgccctt gccccttgca aacgcagcag ctttgactgt ctccggggta 2846281 tttcccgaat gcgagcacaa aataacaaga gacttttcac caagctgaac agggttgcgc 2846341 tgaataaatt cgttggcgct gtagagatcg gagtttattg attttgactc tctgtcaaac 2846401 acatacttac tcggatacat aatggcagaa gaccctccgc atgcgacaaa gaatacatga 2846461 tcaatggttt tccctttcaa atcctgcaag aaagcttgaa cctcacgatt tacttttgct 2846521 gtggcctgac tcaaatcctt cactcctcgt ttttattata taacgttata taacattata 2846581 tattgttata ttaaagtccg cgggtaggat tgtcaatatt attttctgaa atttctcaat 2846641 aatttattcg gatgacagac aaagggtcta tatgcgaaaa aatgcccaaa tcaaaagcca 2846701 gaacttgact taagctctgg cttcgctgtt caatccgcag actgacgtct tatttaaaaa 2846761 ataccttgtc tatattgtac ttcgagtgct gtgtattgat gatatatgtt tcgtaaatct 2846821 ctctttccat tggatcatca actacacata cctcaatttt ataaacttca tctctgtgat 2846881 gtttgatcgg tgaaacagtg tcttcgaaat gcttcttaat tctctgtctt aactttctgg 2846941 ctttaccgac aaacagcagc tcgtcatgaa tgttgtaaaa cataaaaatg ccgcctttgt 2847001 cccttgggat ctggtgaaag tcgatgaatc cgtgaatcgg ttttatcttc ggctcgttat 2847061 cattagctga ctgctgtcgt tcagtgatgg tgacattcgg tgcgggtata tcaattttta 2847121 tcaaaatcag ttcacgtcct ctttttcatt aaagataaat gctaacacat acagaaaaga 2847181 aaagctagaa cagctttatt atatttgttt gtcatgctct tacttattat gcaagtgctc 2847241 cggctggatc ataaggacta aggtctaatt ctgtctgctt tccgagaact agctttgcga 2847301 gctctgcacc caaaaacggc cccatcgtca gtccagaagc acccaaaccg tttgcagcgt 2847361 acaggccttg aacattcggc acggccccta cgaccggcag aaatcccggt gtaaacggcc 2847421 tgaagcccac tcttgtttca acagcagccg catcagcaag acccggtgca acggctaacg 2847481 ctttgctcaa tacttcgtgc tggcctccgg ctgtcacacg aagatcatca agaccggcat 2847541 cgttttcgtg tgtggcgccg gctacaattc tgccgttatc aaacgacaga atgtactgat 2847601 cactcggcgg cattacaacc ggccacgatc ctgtatctgc atctgtcatt tcaaaatgca 2847661 taatctgcgc tttttgaaat gacacttgaa aatgaatgcc aagaggcttc aatatctcat 2847721 tggcccatgc tcccgccgtc acaatgaccg cgtcagccgc aaactgcttt gtatctgttt 2847781 gcacgccggt gactgttccg ttttcaaaaa gcaaggacgc atttcctttg atgaccgttg 2847841 cgccgcgttt ctctgcagcg cttaaaagcg accggcacag cgctcttccg ttcacacggg 2847901 cggcaccgct gatatgaacc gattcatagc cgtcagctaa aatcggaaac agctttttcg 2847961 tttcacttgc agacaagcgg gtaatgtcgc cgatttccgg cgcatcctcc cgtctcttat 2848021 acgccctttc ctccatttta tcgagtttag acgcgtcagt atgaatgctg atggcaccga 2848081 cacgtttgta tcctgtatcc gattcaccgt ctttttccaa ttgatggatt aaatccttat 2848141 agtaccgcgc tcccccctta gcaagctggt accaatcctg attacggcgc tgcgagagcc 2848201 aaggacagac gatccccgcc gccgcatcag tcgcttgtcc cggctctttc cgatcaatga 2848261 cagtaacgcg agcgcctgtt tttgcgagat gataagccgt cgacgcgccc agaatccctg 2848321 cgccgacgat gatgtacgat ttcatatgca aacacctttt ctattataat gtctattcat 2848381 tttaccaaat caaatgcttt ccttcgacct tttgccctaa tgtggaaaaa ccgcgaagtt 2848441 cgtccaatct ctttactctc ctatcgaata tcctgtcact atcaatagag aaaggatgat 2848501 accatgagcg aaaatcgtca tgaaaatgaa gaaaacagac gcgatgcggc agtggcaaaa 2848561 gtccaaaaca gcggtaatgc aaaagtcgtg gtcagcgtga acacagatca ggatcaggca 2848621 caggcgcagt cacaagacgg agaagactaa tgaacgaaaa catcattcct cttaacagac 2848681 atactcaaga gatacccact actgaatctg ttatcaaaaa cagcggcaac tcagaggtcc 2848741 atatcgacat tcacattgat acaatgccaa ttgcttttgc tatattatgc tctgcattag 2848801 ccgcaaagca gatgacaaaa gaggaattcg atatggctta tactcaattg cgagagatga 2848861 acagagaaaa taacagcaga tcatctgtaa agcaaattat caatcaagag acagaagaag 2848921 agtaaaaaac cgcggcccct cggccagcgg tttttcttct gcatacaaaa aggacgcgac 2848981 tgaatcggtt acttctgtac aatttgaata aggttaccgc atgtatcgtc gaagacagct 2849041 attgtgactt cgcccatttt tgtcggttcc gtcgtaaacg tcacgccttt ttcctttaat 2849101 cggttgtact ctttttgaat atctgcaacg ccaaacattg tggccgggag gccttcggag 2849161 aatatcttct tttgatactc cttggcggca ggatgttcat tcggttcgag taaaagctcg 2849221 gttccgtctt gatcatctgg agaaacaagc gttatccacc tgaatttccc catgggaacg 2849281 tcttcctttt ttataaaccc aagtttttct gtataaaact ccagtgccat gtcttgatct 2849341 tgtacaaata tactggtaac aacgattttc atactgtttt tccctccttc gatatgaatg 2849401 aagcatggta ctatgctaac aatctggcta caagcaaaac aacccacaca tttatcagag 2849461 gccctgttct gattttataa aattattcta tccatccttt cagcaaattt ttaagcggtt 2849521 cgttgttgaa tataagtact cgatattttc cctttcgttt tgatgttacg agtcctgcat 2849581 cctccagtac agaaaggtgt ttagctatcg cctgtcgcgt aatagaaagg tcgtactttg 2849641 taataagacg tatcgtaagt tcatacaacg tcagctcgtt gcgttcagat aattcgtcta 2849701 atataagccg ccgagtcgaa tcgccgagtg ctttgaatat agcgtctttg ttcccattca 2849761 tatattgagt ataagcaacc cattagttgc atgtcaagta taagcaactg tatggttgcg 2849821 tgatatagaa actgaaccta tccggcgcag gtctgaaata ttctaatcga taaggaatta 2849881 aaaccattaa aataacagtg gatatgtctc tgaaaaataa aagaagacga acttcaaaag 2849941 ttcgtcttct acaatcaaat tcggcacgcc ggccatttta aagttgataa ctatctctaa 2850001 accccttgat aaacaaagga gttttcatca ttaaccgata gaaccttcca tttcgaactt 2850061 aatcaaacgg ttcatttcaa ctgcgtattc catcggaagc tcttttgtga atggctcgat 2850121 aaagcccatt acgatcattt cagttgcttc ttcttcagaa ataccgcggc tcatcaagta 2850181 gaagagctgc tcttcagata ctttagacac tttcgcttcg tgctccaatg aaatgttatc 2850241 atttaagatt tcattgtaag gaattgtgtc agaagttgat ttgttatcca taatgagcgt 2850301 atcacactcg atgttagagc gggcgccttc cgctttgcgt ccgaagtgga cgattccgcg 2850361 gtacgttact tttccgccct gttttgaaat cgattttgat acgattgtag atgatgtgtt 2850421 tggtgcaagg tgaatcattt tcgcacctgc atcctgatgc tggcctttac ccgcaagagc 2850481 gatagaaagc gtcataccgc gcgcgccttc gccttttagg atacaagccg gatatttcat 2850541 tgtcagctta gaaccgatgt tgccgtcgat ccattccatt gttgcgtttt cttcacagac 2850601 tgtacgcttt gttacaaggt tgtaaacgtt gttcgcccag ttttggatcg ttgtataacg 2850661 gcagtagccg ccttttttca cgatgatctc aacgaccgca ctgtgaagtg agtttgttgt 2850721 gtaaacaggc gcagtacagc cttcaacata atgaacgctt gcttcttcgt caacaatgat 2850781 cagtgtacgt tcgaactgac ccatgttctc agagttgata cggaagtaag cttgtagcgg 2850841 tgtttcaacc ttcacgcctt taggcacgta gatgaaagaa ccgccggacc aaacagctga 2850901 gttaagcgcc gcaaacttgt tatcagtcgg cgggattact tttgcccagt gctcacggaa 2850961 aatatcttca ttctctttca gcgcgctgtc agtgtcttta aagacgatgc cttgtgcttc 2851021 aagatcttct ttcatgttgt ggtatacaac ctcagattcg tactgagcag aaacacccgc 2851081 aaggtatttt tgttcagctt caggaatacc gagcttgtcg aatgtttgtt taatttcttc 2851141 aggaacttca tcccaagaac gctctgaacg ctcagacggt tttacgtagt acgtaatttc 2851201 gtcaaagttc agtgagttta aatctccgcc ccattgaggc atcggcatat tgtagaaatg 2851261 ctcaagtgat ttcaagcgga agtcaagcat ccattgaggc tcttctttca tgcgagaaat 2851321 ttcttctacg atttcttttg tcaatccgcg ctctgaacgg aaaatggaaa cgtccttgtc 2851381 gtgaaaacca tacttgtatt caccaatatc aggcattttt ttagccatcc attttcactc 2851441 caatcctttt aattgccgcc ttcttctttc gcgactcctt tttcaagtgc tttccatgac 2851501 agggttgcac atttgatacg ggcagggaat tttgaaacgc cttgaagggc ttcaatatcc 2851561 ccgagatcta tagaatcatc atactctttc ccttgcatca tatccgagaa aatcttagac 2851621 atggaaaggg cagtttcaat atctttccct ttaatcgcct gagtcatcat cgaagcggat 2851681 gccattgaaa tggaacagcc ttccccttca aacttcgcat cttccacgat gtctccgtca 2851741 agcttcattg tcagtctgat gcggtcgccg catgtcggat tgttcatatc cacgacaatg 2851801 ctgtcattta aaaccccttt atttcgcggg tttttgtaat gatccataat cacctgtctg 2851861 tacaatgtat ctaagtttgc attaaaagac atttgtaaaa tactcctttg tcttttgaag 2851921 agcttccaca agcttatcaa tctcttcctc tgtattatac agataaaagc ttgctcttgc 2851981 agtagcagtt acatccagcc atttcatcag cggctgcgca caatggtggc cggctctgac 2852041 tgcgattccc tccgcatcaa gcacagtcgc cacatcgtgc ggatgaacat catcaaggtt 2852101 aaatgtgaca agcccggcac gctcttccgg cccgtaaacc gttacgccgt caagctggcg 2852161 gaagcgttca agcgcataag ctgcaagctt gtgctcatgg cgggaaatct catcaagacc 2852221 gatttcttcg agaaaatcaa tggcggcacc gaggccgatt gctcctgcaa taatcggcgt 2852281 acccgcttcg aatttccacg gaagctcttt ccaagttgat tcataaagcc cgacaaagtc 2852341 gatcatttca ccgccgaatt cggcaggctc catgttttcc agcagggctt tctttccgta 2852401 cagcacacca acaccggtag gtccgcacat tttatgggaa gaaagcgcaa agaagtcgca 2852461 atcgagatcc tgcacgtcaa ttttcatgtg aggcgtgctt tgtgcaccgt ccaccacaat 2852521 gacagcccca ttgtcatgag cgattttcgc catttcttta atcgggttga ccgtgccgag 2852581 aacattagat acatgagaca ccgcaacaat ttttgtgttg cttgtgaccg tttctctgac 2852641 gtcttctaaa gaaatcgttc cgtcttcctg caacggaata tattttaatg tggcgccagt 2852701 tgcttttaca gcctgctgcc acggaatgat attcgcatga tgctccatgt aggtgatgac 2852761 cacttcatca ccaggtttca ggttggcgcg cgcatagctt aacgccacca tattcagtga 2852821 tgtggtcgtg ccttttgtga aaataatctc agccattgac ttcgcgttaa taaacttgcg 2852881 gactttttca cgcgctcctt cataaccatc tgtcgctctg gttccaagtg tatggacgcc 2852941 ccggtgaaca ttggaattgt attggttata atacttatcc agtgtttcaa tgacagcacg 2853001 cggcttctgg gaagtcgccg cgctgtcgag ataaacgaga tcatgtccgt tcacttgctg 2853061 atgaaggatc gggaactgtt cacgaatatc tgtgatattc attacttcac tttcctttcg 2853121 ataacagaaa ctaattgttt cttaacgcct tcaatcggaa gttcatttac taccggtgca 2853181 aggaatccgt aaatgactaa gcgttctgct tcttctttcg gaattccgcg gctcatcagg 2853241 tagtaaagct gaatagggtc cacacggccg acagatgccg catgtcctgc agttacatcg 2853301 tcttcgtcaa ttaaaagaat agggtttgcg tctccgcgtg ctttttcgct aagcatcagc 2853361 acgcgtgatt cttgctccgc attcgcttta gaagcgccat gttcgatttt gccgattccg 2853421 ttaaagatag aagaagcgga atccttcatc acaccgtgct tcaagatata gccttcagaa 2853481 gctttaccga aatggatgat ttgtgttgtg aagttttctg tttgctctcc tcttccgaca 2853541 acaaccgttt tcgtatcgcc gtatgtgccg tcaccgtaaa ggtttgttgt gttttcggaa 2853601 atcgtgtcgc catcgttcat caggccgaga gcccactcga ttttgctgtc gcgtccgcgc 2853661 gcagcaccgc ggcggttcac ataagttgtc acaccgcttg acagattatc caccgcaccg 2853721 tatgtcacgc tggcattatc acctgtgatg acctcactga taatattgaa gacagcgtct 2853781 ttcgggttta cagtgctgat gtagttttct acatatgtta cagagctgtg gtcttcagcc 2853841 acaatcagca cgtggttgaa tagagctgta tcattgcttt cgtggacata aacagcctga 2853901 accggcgtct ccacctgaac atttttcgga acataaagga atgctcctcc gttaacaaga 2853961 gccgcgtgaa gtgcagttaa cttatgttcg tcaaccttca cgccgtcctt cataaagtat 2854021 ttctccacca agtcgctgtg ctcgcgtgca gcagtcagaa tatcagtgaa gatgacgcct 2854081 ttgtctttca attcttgaga aagagaaaga tgtgccggcg tctggtcacg ctgtacgtat 2854141 aatgttttat cttcgttttc aatgtcgatc agcgctttta cttcatcagt caaatcttct 2854201 aatgaagaaa gcggttcgtt atccactgta tgcttcgcga aattcgtgaa gttccagttt 2854261 gtgatttttg ttttgtcagg tttcggcatc ggcagatcct cagcttgttc aagagcctgt 2854321 aagcgcaggt tcttcagcca ggcaggttct tggtgctttt cggaaaagct tttgagatac 2854381 tcctgatcta cggatagttt tgtacctagt gtcatattaa tccccctaac gcttacgctt 2854441 cttggccaac agtttcgtct tcaatgccaa gttcttgttt gatccagtca taaccttctg 2854501 cttcaagacg ctgtgcaagc tctgcaccgc cggattttac aacgcggcct tgcatcataa 2854561 cgtgaacaac atccggagtg atgtagttta acaggcgctg atagtgagtg atcatcaggc 2854621 agccgaagtt ttcgctgcgc attttgttga tcccttttga tacaactttc aaagcgtcaa 2854681 tatcaaggcc tgagtcaatt tcatcaagga tggcgatttt cggttcaatc atcattaatt 2854741 gaaggatttc gttgcgtttt ttctccccgc ctgagaagcc ttcgttaaga tagcgctgag 2854801 ccatttcagg gtccatttca aggaactcca tgttttcgtc cattttgcgg atgaatttca 2854861 tgagagaaat ttcatcgcct tcttctctgc gcgcgttgat tgctgagcga aggaagtcgg 2854921 catttgtcac accgctgatt tcacttgggt actgcattgc aaggaataag cctgcctgcg 2854981 cacgctcgtc cacttccatc tccagtacat ctttgccgtc aagcgtgatg ctgccttttg 2855041 ttacttcata tttaggatgc cccataatag cagctgataa agtggattta ccagttccgt 2855101 tcgggcccat tactgcgtgg aattctccac cttttatttc aaggtttaca ccctttaaga 2855161 tctctttccc ttcgatttca acgtgaagat ctttgatcgt taatgttgaa gcagccatat 2855221 ctatacctcc aaaaatatat aatcattatt ctcattttat tctcattcta attttataac 2855281 aaatgaaaag taaatacaac tttttatcgt gccttgcaca ttcctcaagt ttaacaaaga 2855341 tcagcacttt attaaagcga ttgaaaaaga aaaagagtgg attcccaccc ttttttaaaa 2855401 gattgatttt ctcaataagc tcccgcagaa atccgcttgc ttttttcata atcaagctct 2855461 ctctgccgct ctactttcat tcttgtttcc agccggcgtc catattcctc gtatccaatt 2855521 ccgtgtgaca gctgcatcgc tttttccatt tctgacgtat aatcgaggtt cagtctgtcc 2855581 tggctgctgc aaataatgaa tcaatccctt catatatttg ctttttattg taccagtgct 2855641 gcgttggatg ccgcaaaaac gatttggcgt gaaatagcgg cagatgagac gaaagcatcc 2855701 tttcagaaca aatgagaatg gtttttcgga atattccttc tcttaatgcg tggtgtttcc 2855761 gaattcctca atgcactgtt gaacgactgt cacgccttgg ctgaaagctg cgccgcctcc 2855821 aaatgccgct gccacactga cggcttcgag aatgttttct tctgacgctc cctgatcaag 2855881 acagcctttt gtatgataga tcatgcaata ttcgtcctga gcattgatgg caattccgag 2855941 ggcgatcagc tgtttttctc tttcagtcag agaattcccg gcaaagcact gttcagtaaa 2856001 ttcgttaaat tttcttccca tcagcggcat cttttgttca aatgtgccta aaccatgttt 2856061 atattgtttt aacgcgtcct gcatgcttcc tctgtcttga ttcaaagaaa atccctccat 2856121 ctgtttaaca ttccttttta ttatgaacag cttttaggaa aatacgcgaa aaaaaccccg 2856181 gaattctcat ccggggtttc agtcttattc agatacagga agcacagctc cgtcgtattt 2856241 tttctcgatg aagtctttga tctttttaga gtgaagaact tccatcagcg ctttgatttt 2856301 tgcagaatct tcttcgcctt ttcttactgc gatgatgtta gcgtatgggt tgtttttcgt 2856361 tgattctact tcaattgcgt cttttttagg atttaattta ttttggatcg catagtttac 2856421 attgatgaag accgcgtctc cttctttgtt ttcatatgct tttgccgtta attcaggcgc 2856481 tacttttttg aattcaaggt ttttcgggtt tttcttaatg tctttcaatg ttgcgtcaac 2856541 tgtttccact ttagaatcaa gagtgattaa tccagcgttt tcaagcattg caagcatacg 2856601 gccttgttca gcaacgttgt ttgtcagaat gattgtcgca ccgtctggaa ggtctttcag 2856661 tgatttgtat gttttagagt aaataccgaa tggctctaag tgaacagcgc cggcattcac 2856721 aagtttgtaa tctgtgtttt ctttcatttc ttgctcaagg taaggaatgt gctggaagta 2856781 gttcgcgtcc acttctttat cagctaaagc tttattgtac attttgtaat cactaagcac 2856841 tttcactttc agcgtatagc ctttttcttt cagcaatggt tcagcttctt ttaaaatttc 2856901 cgcatgcggt gtttttgttg ccgcaacgac aatttctttc ttgccggatt cagcgccgtt 2856961 attcgaaccg caggcagcca taactcctgc aaatacaagc agtaatgcac ccaaaaatag 2857021 ctttttcaat gtaaatcctc ccttatcgtt tgtctataat atttgttatt agatcaccga 2857081 tgatttgaat aataaacacg atgattaaaa taaacacagt agcaacgaag gtaacatcag 2857141 cgttattaga ctgatatcct tctacgtacg caaggtttcc aaggcctcct gaaccaatgg 2857201 ctccggcaat tgccgttgaa ccgattaaag cgatggctgt aaccgtaatg ccagaaataa 2857261 gagcaggcat tgattccgga atcagcactt tgaaaataat cgtagacgtt ttcgcgccca 2857321 ttgatttagc tgcttcaatc acacctttat ccacctcacg cagcgcgatt tcaacaaggc 2857381 gcgcgtaaaa tggtgccgag ccgattacca gcgccggcaa tgcggcgttt ggccctaaga 2857441 tcgtgccgac taaaaatttc gtaaaaccta atagtaaaat aattaaaata aggaacggaa 2857501 tcgatctgaa tatgttaaca acggctgcaa tcactgagtt gaccgcttta ttctgccaga 2857561 ggcttccttt gctcgtcaga aagagcagca agccgaggat gaccccgatg acaaaagcaa 2857621 acagtaaaga aatcagcgtc atataaagtg tttcatatgt cgcgttccat aattcagtta 2857681 aatcaacgtt cgggaagtat ttttcaaaca ttcgtgatca cctctgcttt cacctgtttg 2857741 tcattaatga atcggatcac gttttgcact tcttcctcgt ccccgtcaat gtggatgaac 2857801 agtgaaccgt aagccccatc cttcgtctgc gaaattttcc cttgcagaat attgacgctg 2857861 acattgaagt ttctgatcat ctctgtaatc agaggctgtt cagctgactc accgacaaat 2857921 gtgagctgaa ccatttttcc tgatgctgta tcatcaagaa ggtgctgaag cgtctctttc 2857981 gtttcttccg gctctgtcac ctgttgaaca aatcgttttg tcatttgttc ctttggattt 2858041 ttgaagacat cgagaacctc gccttcttcg accaccttgc cgttttccat gacggcgact 2858101 ctgttgcaga ttttgcgtat gacatgcatt tcgtgcgtaa tcagcacaat cgtcaaaccg 2858161 agtctttcat taatatcgga caatagatcc agaattgaat ctgtcgtttg cggatctaat 2858221 gctgatgtcg cttcgtcaca aagaagaacc ttcggattgt ttgcaagcgc tctggcaatt 2858281 ccgacacgct gcttctgacc gccgctcagc tgggacggat aagatttttc ttttccttct 2858341 aaacctacca gtttaatcag ttcattggcg cgcttgatcc gctcgctctt tttcaccccg 2858401 gcaatttcta aaggaaacat gatattatct ctgacagtcc gcgaccaaag caaattgaaa 2858461 tgctggaaaa tcatactgat ctcatggcgt gcttttctta aaccgcgtcc atttacttca 2858521 ttaatcttgg ttcccgccac ttccacggtt cctgaggttg gtttctcaag gccgttcagc 2858581 agacggatta aggaactctt accagctccg ctatatccta taattccaaa aatctcacct 2858641 tttttaatgg aaagcgagac gttttggaca gcattgacat ctccatgttt cgacttgtaa 2858701 acttttgaaa catcctgaag attgatcaaa gcaatcacct gccttaacac tattctaaga 2858761 aatcttccgg ttttttctgc aaaagaaaag cctttctgca cacttgagca gaaaggctta 2858821 tataaaatgc ctttctctca tctttcaaag ctgaacgctt cgtgtgaatt ggcaccattt 2858881 caacagtgtt gatggttgcc gggcttcata gggcacttcc ctccacctct cttgataaga 2858941 gaaatatata gtctttttcg tccggaaatt cttaatgtag aatagcacgg cgaatgatta 2859001 aatgtcaata aaataaatga tgtcaacttt tactattata ataatttatt attttttaat 2859061 tttttaaaat cctctgaaaa aatccatttg tcagccagag aatggcttcc agctttaaca 2859121 gggccctgaa tgaccccttt actttgaggc ttccgctctg aataaggtgc tgaagggaaa 2859181 tgtctccgtg caataaatca ataatttccg tttggtttcc gtaaaaggtc aggttggacg 2859241 tttggggcgg agaaactttt ttcatttctc cctgttcgtt tattgagacg gttaaggctt 2859301 ctgcttctcc ttggaaggta atgagcaatg ttgaggcatt caaaaggggt tttaaaaaca 2859361 gatgctgata ctcatcttct aaaacttccg ctttctccat atgtacaacc tcctatttgt 2859421 tggtcataca tacacatttc tctctttgtc gcaagaaccc ctttataaaa cgaacgacaa 2859481 tttcattgga tatgctgaga aatatgtcat aaatgggatg cggaagatga tttttgtttg 2859541 atcagctcat ataaataaga aacggaatga aatgcatatc ctctttcgac catctttccg 2859601 cctttaaaca gcagaaaaca agggacgctt tcaatttgat acgcttttgc gaatgtcgga 2859661 gagtaattga cattgttttg atagaaggcg acatccggca gcatttcttt caccactgtc 2859721 agcattttgc ttgcaagctg gcaggtgccg caaaacggag tatataaata tagaaggtac 2859781 acatcatctt caatgtgatc aagttcgtgt tcttggagtt ctttcatgct atacacctcg 2859841 ggactttctt tcaagaaaaa tagtatggac attcagattc gcacgcagca atacagaagc 2859901 gatatggtgc ctgggcgcag ccgctacttc cttataggct ctgtcgacat ggagatggca 2859961 ggcttcatta aattcacgct tcagctgttt tctcaatttc tcacctgatt catcagcatc 2860021 aactaatata tagacgtctt tatcataaag ctcgtcagcc aattcctcga gcctcagctg 2860081 gctgattgtt ccgtttgtgc agataatgcg catcggttca ttcaggacgc tttcgatttt 2860141 ctctttatct gatttcccct cgacaatcat aaccttttcc agctcatcca tcttcatctt 2860201 gttcacctgc cgcgtcaaat ttgaaatgtt cagattgtaa aagaaggcag tgaaattcac 2860261 cgccaacatt aacaccagcc gttttcgtag tcacaatcta catattttgc gtcgtctcca 2860321 gagaccacat cggctgtctt ataaaatttc tcattttcaa aggaataacc ggacttaagc 2860381 tcatattcat tcatgcttgt catttggccg atcatctcat tatcatgata taacgagagc 2860441 cggccatttt gaaagcggcc tgtcacgtca ttggtgacat cgagcttttg tttgtcgaaa 2860501 gccatattgg acacctccca taacgttagc gtgtccaatt gcttttacgg ctatcctgtt 2860561 ttagtcttct tgtgtcatct cttcgtattg ctctgctgtc atcagttttt caatttcaga 2860621 agcgtcagat ggctcaacga cgatcatcca tgctttttcg tacggagatt cgttgacgaa 2860681 ttccggactg tcatcaagat cttcgtttac ttccacaacc gttccgttaa tcggtgcata 2860741 aagctcagat accgttttaa cggattcaac actgccgaat ggctcgtccg ctttgatttc 2860801 agcgcccact tcaggaagtt cgacaaacac gatgtcgcct agttcggact gggcaaaatg 2860861 cgtaattccg attctggctt tttctccttc aacttttacc cactcgtgtt ctcctgagta 2860921 acgcaaatct tttggtatgc tcaattgaat ccctccattt tttacagcac tacaataaga 2860981 agataccaca cttttcaaaa aaaatttaca ttaagcccag ttttcttcaa attggtcttc 2861041 tttaaatccg acagtcactt tttcgccgtc tgttgtaagc gggcgtttaa ttagcatacc 2861101 atctgaagcc agcagttcga gctgttcgtc ctctgacata tgatacagct tttccttgag 2861161 attgagctcg cggtatttca tgccgctcgt gttgaaaaat ttcttgagat ccagcccgct 2861221 tttttcataa agcgctttta attcttcttt gcttggcggc tgctcagcaa tatgtatttc 2861281 gtttatttct ttcccatgct cttcaagcca cttctttgct ttgcggcacg ttccgcattt 2861341 agggtaccag taaaaagtta acgacatctt cttccccctc aataaaataa tcgaggttat 2861401 tttaacacag tttgttttaa aaacctaaaa cagtgcttct taaaaaagag ctccgcgcat 2861461 gcggagctca tggccaatca gacagtatat ttctcagcct caaaaatgcc tgccgccgcc 2861521 tcgcgttttt tctgaatcac gtttttaggc gttacgcgtg tcagcttgcg cagagcggaa 2861581 agcatcatgc ggagtgaatc tccttcttcc attgcgataa gggattcctt tgcatgcgct 2861641 tcgatttcgt taaaggcctc ttgaacgaaa atttctgtgt acagcacctt ttgcgctgct 2861701 ttttcagcgc cttgtgcggc aatggccttt tccgttctga gcacggctga ttccattgcg 2861761 tatacattgc tgacgatatc cgctacgttc acgagaattt cttgctcacg atcgatcgct 2861821 tttccgtatt tttgcgcggc taggccggca gcaaacaacg caattttttt ggcttgcttg 2861881 acgatatatt tctcctgctc taagacgccg cttccaggct cttcaggcat aagcatcatg 2861941 agttcttcct gcagcgactg cgctttttcg aataaaggca gctcgccttt aagcgctttt 2862001 ttcaggaagg tgcttggcac gattaaccgg ttgatttcgt ttgtgccttc aaaaatccga 2862061 ttgatccttg aatccctata ggccctttct acttcgtatt cctgcataaa gccgtagcct 2862121 ccatgaatct gcacgccttc atcaacgata taatcaagcg tttcagagcc gaatacctta 2862181 ttcagagagc attcgatggc gtattccgca atcgatttgg cgatttgccg gccgtccttg 2862241 agatcttcgg ccgtgaactg gctcatattg tcttcaaaca gcccgacggt tctgtataca 2862301 gagctttcca tcgcatacag ccttgaggcc attgtcccga ttttttcctg tgtcaatgaa 2862361 aaaccagcaa tcggcgtttt aaattggcgg cgctgatttg cgtatgccgc agacagctcg 2862421 atgacgcgtt tagatgcgcc gattgtgcca accgccagtt tgtaacggcc gatgtttaaa 2862481 atattaaagg cgatgacatg ccctttgccg atttctccga gcaggttttc ctttggcact 2862541 tcagcttgat ccagaatgag ggttcttgtc gatgatccct tgattcccat tttcttttct 2862601 tccggtcccg tggagacacc cgggaactct ttttctacaa taaaggctga aaacttgtcg 2862661 ccgtctacct tagcgtaaac tacaaataca tcggcaaaag cagagttggt aatccactgt 2862721 ttttcccctg ttaatacata atgggttcct gcttcattca gcacagctgt tgtttttgct 2862781 ccaagtgcat cagacccaga gccaggctca gtcagagcat aagcggcgat cttttcgcct 2862841 gaagcgagtc caggcaaata ttttttcttt tgttcttctg acccgaaaaa gacgatcggc 2862901 aaggaaccga taccgacatg cgcgccataa gaaagagaaa agcttcccgc acgcgaaaat 2862961 ttctcagtga tgagtgccga gctgatttta tcaaggccga gcccgccgta ttcttccggc 2863021 acatcggcgc caagcagccc tagttcgccc gctttcttca acagtctgac agaatgctcg 2863081 aattgatggt tttcgatatc atctatatga gggagaacat cttgctcgat gtaatcctct 2863141 gttgttttcg caatcatttt atgctcgtca gtgaaatcct ccggtgtata catttgatcg 2863201 tatgtgacat cctcgattaa aaatccgccg cctttttgta cgtcagccgc tttttttgcc 2863261 atttgttttt ccccctttag cataattcaa atacaccggc cgctcccatt ccgccgccga 2863321 tacacatggt cacgactcca aattgctcgt ttctccgttt catttcatgg atgagtgaga 2863381 gtgtaagctt tgtgcccgta cagccaagcg ggtgtccaag cgcgattgcg cccccgttga 2863441 cattcacttt ttcttcatca attcccaatt ccctgattac ttgaatggcc tgtgaggcaa 2863501 aagcttcatt cagttcaaac aagccgatgt cctgcagctg aagtccggca agcttcaaag 2863561 cgcgcggaat cgcttccacc ggtccgattc ccatcacttc cggcggcacg ccgcctaccg 2863621 caaaggagcg gaatttcaca agcggcgcca ggccaagagc atcggctttt tcccggtcca 2863681 tcagcatgac agccgccgct ccgtcactcg tttgtgagga attgcccgca gtcaccgtcc 2863741 cgtcaacgga aaaggccggg cgcaatgtcg ataagatgtc tgcagtcgtt tgcgggcgaa 2863801 caccttcatc ctgagaaaac acaaactgtt tttccatagg cttatggtct tctccgattt 2863861 ctgtcaccgt cacttcgacg ggtacaattt catctttaaa ttttccttct gcaagggctt 2863921 tagcggcgtt ttgatggctg cgaacggcaa acgcgtcttg atcctcacgg gagacgccgt 2863981 attttttcgc gacttgctcg gctgtgtgcc ccatgctcat ataatattcc ggtgcctttt 2864041 ctgccaaagc aaggttcgga cgggtaacat gccccatcat cggaacttgc gacatggatt 2864101 ctgctccgcc ggcgatcgct gtatcgtagg cgcccagcat aattttttct gctgcatacg 2864161 caatagactg aaggcctgaa gagcaatagc ggttaactgt aatcgccgga accgtgtacg 2864221 gcaggcccgc gagcgcaccg atatttctcg ccatattaag cccctgctcc gcttcaggtg 2864281 ttgcacagcc gataatcaag tcatcaatat tgccttcgta gccgcctgcc cgtttcagcg 2864341 tttcttttac acaaatcgct cccaaatcat ccgggcgaac ggtggccaac gatccttttt 2864401 ttgcttttcc aaccggtgtt cttgcacctg acacaatgac tgcctctttc ataagctccc 2864461 tcctaattcc gtaaaggttt acctttcaca agcatatgct gcattctcgc ttgagatttt 2864521 gcctctcctg acaaactcaa aaacgcttct ctttcgatct ccaataaata ctcttcatca 2864581 acctctgtac caaacggcac ttttccgccc gcaatgacat aagcgagttt tttcgcgatc 2864641 ttaaaatcat gctcagatat atagccggac agcttcatct gctcagcgcc aagcaagagt 2864701 gccgcataac cggtttctcc cggcaccttg accttttctt ttacaggcgg ccgccagccg 2864761 gtatcgtata aagatgcggc cagctgcttc gcatcgtata acaggtggtc ttgattcacg 2864821 ctgatctgat ccgtttcttt taagatgttc atctcacgag cctcttgagc ggaagcggac 2864881 actttcgcca tcgcgattgt ttcaaatgtt ttcattgccg cattcatcgg atcatggccg 2864941 cggcgaagat ggttgatgta cagctctttg ttacctcctc cgccagggat gaggccgaca 2865001 ccggattcca caagtcccat ataggcttcg cttgccgctt gaatgcgcgc cgccggcagg 2865061 catgcttccg ttcctccgcc gagcgtcatg ccaaatggcg cggcgacgac cggtttcgca 2865121 ctgtatttga tcttcatcat cgtctcctga aaacggcgga tcacaaaatc aacttccaaa 2865181 aagttgtcat cttggacttc cattaagatc atggcgagat tcgcgccgac gcagaaattt 2865241 ttcccttgat tgccgatgac aagccccttg taattccgtt ctgtttcctc taatcctttg 2865301 tggatcattt gaatgatatc gaggccgatc gcattgcttt tcgaatgaaa ttcaagaagg 2865361 gccacatcat ctccaaggtc aattaagctt gctccgctgt ttttcgcaat cacgcctttt 2865421 gtttctttaa gtgcttgtaa atgaattcgt tttttgtttt ctttcacggc tctgtattcg 2865481 ccgcggtcat aataaaatac cgttccgttc tctttgatgt agaaggtttc atttcctttg 2865541 tccagcatct cttttatcca gccaggcata tctgctccaa gctgctcaag cttttccgct 2865601 gactgcttga ggccgatggc gtcccacatc tcaaaaggtc ccagttccca gccgaatccc 2865661 cacttcatgg cttggtcaat cgcatgaata tcatcggcaa tctcgccaag cagctcggct 2865721 gagtaaagca gggtttgaga agtgatattc cacagcaaac ggccggccct gtcatccgaa 2865781 taaataagcg ctttcatttt ggcttttgtc ccttttgcct gttttgccgc ttcaagtgcc 2865841 ggtgatttca tttttgtccg ctcgccgtaa gtaagcgtca ctgggtcaag ctcataaatc 2865901 gtttttcctt cttttttata aaagccttgg ccggccttgc ttccgatcca ccctttttcc 2865961 agcatatcgt tcatgaagct tggaatgcga aacacttctt tttcatcgcc atcagctttg 2866021 tcatacacat ttcgggcaac gtgggcgaat gtatcgaggc cgaccacatc aagcgttcta 2866081 aaggtggcgc ttttcggcct gccgatcagc ggtcctgtga tcgaatcaac ctccccgacc 2866141 tgataaccgc ctttcagcat ttcttggact gtcacgagaa gcccgtaagt cccgatgcgg 2866201 tttgcgataa agttcggtgt gtcctttgct gtaacaacgc ctttcccgag gacattttct 2866261 ccgaaagctg tcataaactt taaaatatca ggatccgttt ccttaatcgg aatgatctct 2866321 agcagcttta aatatcgtgc gggattaaaa aaatgcgttc caagaaaatg ggctttaaaa 2866381 tcatccgacc ggccttcagc catttcctgc actgatatgc cggatgtgtt gcttgagacg 2866441 atgcttccag tctttcgatg ttcatccaca agagcgaaaa ttttcttttt gacttcaagg 2866501 ttttcgacaa cgacctcaat aatccaatct gcttctttca gtttttctgc atcatcctcc 2866561 agattgccag gtgtaatata ggaggtattt ttcgctgatg tgaggggagc gggcttttgt 2866621 ttcagcagtt ttttcatcgc ctgccggctc agcctgctgc gcacctccga actgtccttc 2866681 gtcagcccct ttttttcctc ttcctttgtc aaatcgttcg gcacaatatc tagcagcagg 2866741 acaggaattc cgatgttagc caaatgcgcc gctatcccgg aacccattac ccccgatcct 2866801 aaaacggctg ccttccgaat gtgtttgtgc atgagatatc ccccttgaac attgaatgaa 2866861 tagtcattca ttttttgact aaaaaaaatg aaacccgttt cttctttcat cttaaaagat 2866921 ttccggttcg acttcaatag ctaatttgtt atttttttgt atgaagccta taaaagtcgg 2866981 gcaacttaag cccggaggtg aagggaatgg tacgagagaa aaaaaatccg tcttcagcgg 2867041 cagtcagcgc ggcgagcgta aagggagatg ccggtccgac tcagcattac ggcggcggaa 2867101 aacggacaag tcaaaatcag cagtataaaa aacataacat gggacaatca taatgcagct 2867161 gcttcccacg gctgctttca ctttttcaaa attcctttta acacaaacgc tgcattggca 2867221 ggccgttcgg caattcttct cataaagtag ctgaaccagt ccgttccata tgggacatac 2867281 acacgcattc tgtagccttc cttggcgagt tccttctgac gctccggcct gatgccgtat 2867341 agcatttgaa actcaaattg cgatgcgggg atttgatgtt cggcgacgag ctgtttcgta 2867401 aatgcaatga tgtcatcgtc atgtgtggcg acagccgtgt agttcccgct taacaactgc 2867461 agctttatta agctctgaaa atgaaggtcc gtgcctcttt tgtcgggaaa cgctacagcc 2867521 gcagattctt tataagcgcc ttttacaagt ctgagattcg gctttaagtc ccgcatcttt 2867581 ctgatatctt ctgccgcccg gtacaaatac gcctgaatga ccgtgccgag cttctcaaat 2867641 tcctgtttgc attgcctgta aatagaaagt gtctgttcat aatgagaata gtcttccata 2867701 tcaatggtca cagcaacatc atattgcttc gcaacggaaa gaatggcgcg caaatgagta 2867761 agagcaagtt cttctgaaag atcgagcccg attgaggtca gcttaagtga aagctctgaa 2867821 ttcaattgat gttcggcaat ggcttgaatg gctttcttgc attcctctgc gacttggttt 2867881 gcttcttttt ccgaagctgc atactcgcct aaataatcaa ttgttgcaca caaaccggat 2867941 ctgtttagcc ttttgacggt cttaaccgcc gattcaatcg tatcccctgc gacaaacctt 2868001 cgtgctccaa gccgcgttcc gtatgctttt gcgaacttgg taagtgtttt attttgagat 2868061 aagaataaaa acacatgtct caacatccga ctccctcccg ccgtcatctt caaaacacct 2868121 gtatataact cccagtctga aggaaactat aaaatgaaca gaaaccaaag gaggatcaca 2868181 atggataatc agcagcaatc tcaaatgccg ccttccgtta tttcgacaaa ggatcatttg 2868241 tatctcaatg acatgctgaa ctggaatttg ctcgcgatga aaaaagcgca tttcatggcg 2868301 cagcagtgcc aggatcaaac gttaaagcaa gaactcgacc gcgtcggaca catgcatcat 2868361 gatcactatc aaagaatatt aaagcacctg cagccaggcc agcagcagtc cggctacatc 2868421 caataaggag gcgccagaat gaatcagcaa aatcaaaaaa tcagcaaccc gcagacacct 2868481 gtaccgacaa catcggaaat gaatgacaga gatttcgtca acgaattgct gacaaccgaa 2868541 aaatacatga caacagctta ttgcactgcc ttgcacgaat tcagccacga gtctctttat 2868601 caggatattc aatccatttt tgatgagtca caaaaagcgc aaagaaaact atatgatctc 2868661 atgttccaat atggatggta ttctgttgaa gcggaggatt cacaaaagct gcagcagtcc 2868721 tatcaaaaat tccagcagac cattcagcag cagtctcctt atcagcaata acaacattag 2868781 taaaaaggat acgatgttct ttcgggcatc tatccttttt ttgtgtaaaa tcagttgact 2868841 tttcatttac gcttatttat atttaataag cattaactat tttgtcatta aaatatatat 2868901 acagtgtatg taacagaggg gaaatgaata tgaagagtgc ggatcagtta atgtccgata 2868961 ttcaattatc gcttcaggcg ctctttcaaa agatacagcc tgaaatgctg gaaagcatgg 2869021 agaaacaagg tgtcacccca gcgcagctgt ttgtgctggc cagcctaaag aaacacggca 2869081 gcctcaaagt ttctgaaatt gccgagcgta tggaggtgaa gccaagcgcg gtgacgctga 2869141 tggcagatcg ccttgaacaa aaaaatctta tcgccagaac acacaacaca aaagacaggc 2869201 gagtgattga tctcagtctt actgacgaag gagacataaa gttcgaggag gttttggcgg 2869261 gcagaaaagc cataatggcg cgctatcttt cctttttgac ggaggaggaa atgctgcagg 2869321 cggcgcatat tacagcaaaa ctcgcacaag cagcagaaac ggatgaaaag caaaacatga 2869381 aaagaggaaa cggatgaaaa tgagtaaaga aggcaaacaa tcaaaacgaa cgttattaat 2869441 aacaggctta attattgcca tgtttttttc agcccttgac ggtaccattg tcggaacggc 2869501 catgccgaaa attgtcggtg atctgggcgg tttgagcatg atgacctggc tgacaactgc 2869561 atatttgtta acatcaacaa ccattgttcc aattgccggt aaactggctg atttattggg 2869621 acgccgcatt gtctatgtat caggtttgat tatttttatg gccgcttctg ctttgtgcgg 2869681 aatggccaac aacatgacgg aattgattat cttccgtgga ctgcagggca tcggcggagg 2869741 catcatgatg ccgatggcga tgattgtcat cggtgacttg ttcacaggaa aacagcgtgc 2869801 taaattccaa ggtgtctttg gcgcaattta cgggctggct tcagtgattg ggccgcaaat 2869861 cggcggctgg attgtagact cgttaaactg gaaatgggtt ttctatatta acctgccagt 2869921 cggaattatt gcggttattt ttattgccag gggattacag ggacgccagc agactggtcc 2869981 gatcaacttc gatatcgctg gtattttcac aatgattgtc ggtgtggtca gcctcctgct 2870041 cgccttaagc tttggcggaa aagattatgc atgggattca tggcagattc ttgggttgtt 2870101 cgctctcgca ctgatcggca ttgtcagctt tatcatcgta gaatcaaaag caaaagagcc 2870161 aatcctgcca atgtatttat ttaaaaacag aacatttaca tttctaaact tgatcggctt 2870221 ctttatgagt atcggtatgt ttggcgccat tacgtttgtt cctttcttta tgcagggaat 2870281 tgtcggtgta agtgcgtctg aatcgggtac aattatgaca ccgatgatga tttctatgat 2870341 tatcacaagt atcatcggcg gacagcttgt ttataaaatt gggattaaac cgcaaatcat 2870401 tacaggcatg ctggttatgg ccggcggatt cctgctgtta acgacattgg atctcgacac 2870461 gagcaagctt gtcgctacat cttttatggc gattattggt ctgggaatgg gtcttgttat 2870521 gccgattctg acattggctt tacaggaaag cttttcgaag gaggagcttg gagttgtcac 2870581 ttcatccagc caattcttcc gttctatcgg cggaacattc ggcattacca tgctgggagc 2870641 cgtaatgaat gcgagatcag gaaatctatt aacagataaa ttggttccat atttagactc 2870701 tcttccggca caggcaagct cgtttgccgc ccagctaaag ggtatgattg atacaaatcc 2870761 gcaagggctg ctgcaatcac tgttcagtcc ggacgcggtc aaacaaatcc ctgcggcttt 2870821 ctcatcccat attgtgccga ttttaaaaac atcgttgatg gattcgctcc acagcgtgtt 2870881 ttatacgggc ctgatcttta tcgcagtcgg agccgtattc accttgttct taaaacctat 2870941 caagctatca aataagaaag cggaagacca acaagaaaaa gagaaggcgg caaaagccgt 2871001 tgaatcacct tcccattaat agagcacccc gcgggtatca atccgcgggg ttttttattc 2871061 aatcatctgg gctcttccat ttccgaaaga ccaatcctca tcctgatttc cggccagcat 2871121 gataaacaca tcttcttttc ttacaccaag ctcggaatga atccggctcg cgattgagcg 2871181 gtaaagtgct tttttctgtt cagttgttct tgactgtttc agtgtaaaat gaatgtatat 2871241 cagttcatca gtacgctcga cttggagata aaatggatca taaaaaaatt cgcttttttc 2871301 atattgtctg atgacttgga aatagtcatc ttccggcaca ttgatttctt caatcatcga 2871361 ttggtggata gtcctgctca gtttttgaag ccacacttcg cttcttcccg accgtaaatg 2871421 aatctgtaca aatggcatct ccccgcatcc ctttctttac agcgtctgtc cgctgtcaat 2871481 tgtgataatt tggcctgtga gtgattcctg ttcaattagt gaacaaatca atttggcaac 2871541 atcatctggt tcagcaatac actgcagcag caaagagccg atcatgcttt tcattttttc 2871601 ttcccgtccg gcccaccatc tcgttgccac agctcctggt gctacaccgc tcactctgat 2871661 ttcaggcgct aaggcgtggg ccaatgattt cgttaaaccg tgcaccgctg attttgatac 2871721 tgcgtaaggc attgatgagc cggcaccagt tatccctgcg atgctgccga cgtttacgat 2871781 cgccccgtcc ttgcttttct tcatgaacgg aaccactgcc cgcgcgcaga aaaacatccc 2871841 tttcacattg acggcataca gctcatccta gacgtcttct gtcgcagcct caagatcatc 2871901 cattggaata tgccgtgtaa tgctggcatt gttgactaaa atatcaaccg tgccgtgtgt 2871961 gttcacgatt gcttgaatca tatcctgcac gtcgctgttt ttggatacat ctgcttggat 2872021 ggcgaaggct tgcccgccag ctttttgaat catttccact gtttcctccg cttctgattg 2872081 cgagcgtgaa taattcaccg ccacaatcgc cccacgcttt gccaattcca tactggctgc 2872141 ttttccgatt cctgtgccgc cccccgttac gagagctatt ttgttcaaga cattcattgc 2872201 cgccactcct tgctgttgac taaagtatat ttctgattcc attgtaatcc agctttgatg 2872261 ttacgtataa tgattgttaa agatactaga tatcactcag attgatagta aacgaacgga 2872321 ggagttcaaa atggaaagcg gagatttacg tgtgtttcaa atggtagctc gtgaagggac 2872381 cattacgaaa gcagccctgc agcttggcta tgtacaatcg aatgtcacgg ccagaattca 2872441 acaattggaa gctgagctgg gtaccacact gtttttgcgc cataatcggg gcatgacact 2872501 ttctgcaagc ggaaaattgc tgctggacta cgcaaataaa attataggcc ttcttgatga 2872561 agcgtctaaa gcgctctcat cctccgcaga accaagcggg ccgcttatga tcggctgcac 2872621 tcagacaacc gccgcggtaa ggcttccaaa gcttctggca tcttattatg aagaacatcc 2872681 aaacgtccag ctgtctttaa caacaggaca tacgcaattt ctccttgata aagttcttcg 2872741 ttatgaattg gatggcgcgt ttatcggatg cgaatgccat catcctgagc tcgaatccta 2872801 tcctgcgttt gaggaagaac cagtagttgt ttcggctgcc tccgtgcccg atgttgagga 2872861 agccatcaca aagccgattc tcgtttacag cacaggctgt tcgtatcgag aaacacttga 2872921 aaaatggctg cgttccgtcg gtgtcacaca gccggtcatt atggaatttg ggacgcttga 2872981 agcaattatc ggcggggtta cagcaggtct tggcatctcg ttgctgccaa gaacggttgt 2873041 gcagaaacat gaagcagaag gatcaattcg attgtacccg ctgcctgaag ctctcagcca 2873101 gatgaaaaca gagtttattg ttcgaaaaga ttcgtttatc agcagcgcgc tgagaacctt 2873161 tatggattcc tttacgccag ttaaaacggc tgaatcacaa aaaagcagtc tgctataatg 2873221 aacagactgc tttttggcta ttgtttgttt cgatgcgctt catttaattc cttaatatgc 2873281 tgaatgatct ctttaatgcc ctgcttcgcg tcggggtatg tcgcattcca atgcttagcg 2873341 agcggaggca tgcttttggc tatatgggtg tacaaaatcc attgcttcac ttcttctttt 2873401 agctcatcgt ttgtttcacc aagcagaagc tcagtatact tctccagcaa tccatcaagc 2873461 tgctcctgaa gtttttgttc cattttccat cttcctttcg aaaaaacagc aaggagcttt 2873521 ctcaattgaa agctccttcg ctgcgttatt tatccatgtg atgtgaaagc cgcttcctgg 2873581 acaatgcatc tgcccctgcc atgaggaatg caaagaggcg ttccgaagag cgggtcctgt 2873641 gtaacctgac agttcataga aaacacattt tgcacaagat cacaagtgat gacctcttcc 2873701 ggacggcctt ctgcataaat ccgtttatct tttatggcca caagatgatg cgcatagcgg 2873761 cacgccaagt ttaagtcatg gagaaccata acaatcgtcc ggtcttcctt ttcattcagc 2873821 tcaaacagca aatcaagaat ttcaatttga tgcgtcatgt ctaaatacgt cgtcggctcg 2873881 tcaagaagga tgatatccgt ttcctgggca agcgtcatcg cgatccaagc ccgctggcgc 2873941 tgtccgcctg acaaagaatc aacggcacgg tcagccatgt cctcaagctt tgttgcttta 2874001 agcgctcttt caactgcttc ctcatcctct tttgaccact gcttcagcca gttttggtaa 2874061 ggatatcttc cttgcttcac cagctgatgc accgtcagcc cctctggagc cgaaggacct 2874121 tggggcagga ttgcgagctc ttttgcgact tccttcgtcg gaagcttggc aatcgctctt 2874181 ccttccagca gcactgaacc gcctctcggc ttcatcaggc gcgctaatga acgtaaaagt 2874241 gtcgattttc cgcagccatt gctgccaata aatacggtaa tttcaccttt gggaattgtt 2874301 aaattcaact catcaataat aacggcatcc ccgtatccta agctcagcgt ttctgtagaa 2874361 attgcactca tacccataac cgctcctttt tgctggcttt ttagcagcac tatgtattgc 2874421 acgttttcta tatacatgct tttaagtcaa ttgtcatcaa tgcaaatgat tccgatattc 2874481 agccatttga tatggtcata tatccctcat tgtagcagaa aacactgact ttgaaaatca 2874541 ttttcaatta gttttatgga cataattgac gtttatgggt tttttatcac aagattactt 2874601 cttgatttct ctgatggagc cgtccttcag cttcaatttt aaatcgatat gatcataatg 2874661 actgtccaga ttaaatgctg ccagcacact gtgtatcact tctgtttcag ccatttggtc 2874721 tgtcacggaa agctcgctca aaatcatttt catctcatct aacgcttctt ctccttcctg 2874781 attgacaccg gagagcttat cctgtatttc cgctttttcc tgagtcccgt tctttgtata 2874841 gattccttca taacggttat gctcaccatc cccgtagctc acacgaagcg aaaaattact 2874901 gtagggaacg gacttcagct gggtgacggc tgtattttct ccttctgcct gatgctggtc 2874961 ttcattgaaa cggcagcccg caatcagaac cactgcgaga catacagccc cggctgctct 2875021 gatcaaatgc atatgtttcc cccctgtagg attccattta ttttaggtat atccagagaa 2875081 tgaaatcctc attcagagaa gaattgaaaa agccggggca tttaacgcca cggctttttc 2875141 tttaagattc ggtcatttgt aaaaaggttt cggcgtcacg cacagccagc ttgatggcat 2875201 tctcccagaa atcgcgcttt gtgatgtcag cgcccaaatg cttcatcgcc aaatcctcca 2875261 ctgtcataga agccgtatcg cgcaatagcg ccatatactt ctcttcgaat gtgtcttttt 2875321 cttcaagcgc caacgcgtaa ataccaagag aaaacaggta gccgaatgta taagggaaat 2875381 tgtaaaacgg caccctcgtg atgtgaaaat gaagctttga tgcccaaaaa agcggatgat 2875441 attcttctaa cgcattgcag tatgcctctc tttgcgcctc ttccatcagc tcattcaagc 2875501 ggctggccgg taccactccc cgctttcgtt cctcgtagaa tctcgtttca aatagaaatc 2875561 ttgcgtgaat gttcatgaag aacgcaacgc ttctttgcac tttatcctcc agaagaacaa 2875621 gcttttcttc cctcgtctcg gcctgctgga cagtcgcgtc cgccactatc atctctgcaa 2875681 acgttgaagc tgtttctgca acgttcatgg cgtaggaacg gtttaacggc ctgacgttga 2875741 gcattgcttc ctgatggaac gcgtgcccga gttcatgcgc aagggtagag acatttgagg 2875801 cgcttcccga aaatgtcatg aaaatccggg attccccgct gtccggaaaa ctggtgcaaa 2875861 agccgccgac tctttttccg ctcctgtctt ccgcctcaat ccagccgtcc cgaaacgctt 2875921 tttcagtgaa tgaggacagc tttttgccaa acgttgaaaa ctggctggta atgatatttg 2875981 cggcttcatc atacgaatag acctttccgt cagaaccgat cggtgcctcg acatcgtacc 2876041 agctgagttt ttcaaggccg agcatggatg ctttccggtt caaaaactga acgaacggct 2876101 tcttgttttc agtgatgacc tgccacatcg tatcaagtgt ttcttttttc atcctgttaa 2876161 tttgcagcgg ttccttcagg acattctccc agccgcgcgc tttataggtt tcaagccgga 2876221 atcccgccaa atgattcagc gtgctgctga aaatatcttg cttgctctcc caagcttggc 2876281 ggaaacgttc atatactgtt tttctgacag tacggtcttg atgatccatc atattctccg 2876341 cctgaccgac agacaattgc ttgttttcac cgttttcctc atacgggatc gtcattttcc 2876401 cgacaaccat attgtataag tcactccaag cgtgatatcc gtccaccgca aggtttccga 2876461 tcagtttttc cttaccgggg ctaagctttt cggcaaccct ctgtcttctt tcatttaata 2876521 tgtaagaaac atcgcgcaat cccggttttg ttaacaattc attccacacg tcttgattaa 2876581 tgtccacaag tttatgatct aatgtaacga gcgacgattg aaaatctgcg gaaagccgat 2876641 tcatgaggcc tgatgctcta tagccttttg atcattgata ttctgggcct ggaggcaagc 2876701 aacaaaagcg ccggcctgct gaagcttgac ggatgtctgt tcgaataaat caagcaacgc 2876761 ggtcagccct tcagcctctt caggcgattc aggcacctga aacgcatcag tcctgtcttg 2876821 aaatgcacgc agactttgtg acagcttctc aatataacct ttgaattctt ccgattggct 2876881 cccgccctta aaaaatgaat caagatccca tctttggcct accccttgca gcgccatatc 2876941 acaaaacccc tttccttctt tcgttctatt atagaacaat tctgaattat tgtataaaaa 2877001 tttctattac aggcgtcatt tcgtgttcag gatagtacaa tagctgtagc agtttaatag 2877061 gagggttagg atgaataaaa aaatagccat cgtgacagga gcgtccagcg gcttcggtct 2877121 gctggcagct gtaaagcttg cccgatcatt tttcgtgata gccacatcaa gacagcctga 2877181 aaaagcggaa cagcttcgag aattggctgc agcacacaat gtgtctgatt ctattcacat 2877241 tacagctctc gatgtcaccg atgaacaatc tatagtctca ttcggaaaag ctgttagtgc 2877301 ttacgccccg atcgatttac tcgttaacaa cgccggaacg gcttatggag gatttatcga 2877361 ggatgtgccg atggaacatt tcagacaaca atttgaaacg aatgtcttcg gtgtgatcca 2877421 tgtgacaaaa accgtgctgc cttacataag aaagcatggc ggcgcaaaga ttataaacgt 2877481 gagcagcatc agcggactga caggattccc agcgctgtcg ccatatgttt cttccaagca 2877541 tgcattggaa ggtttttctg aaagcctgcg tatcgagctg cttccgttcg gtatcgaaac 2877601 cgctttgatc gagccgggct catacaagac atcgatctgg tcaacgtcat tatcaaattt 2877661 tatgtcggtg cctgctgacg attcagccta tcatcaatac tataaaaaga tcctttccta 2877721 tgttcaaaaa aacggagaag aaagcggaga tccccaagag gttgccgacc tcatttatca 2877781 attggcaaca aaacagcaca taaagaattt gcgatacccg atcggaaagg gcatcaagct 2877841 caccctgctg ttccgatcgc tttttccttg gtctgcgtgg gagtctatcc tgaagaaaaa 2877901 gctattcagc tgatctaaat tataattatt ataatttagt attgattttt atttagtata 2877961 tgatataatt aagtcaacag atcacaagga ggacgttatc ttatgaaaac tgaaaacgca 2878021 aaaacaaatc aaacattagt tgagaattca ctgaacacac aattatcaaa ctggtttctt 2878081 ttatactcta agctccaccg tttccattgg tatgtgaaag ggcctcattt ctttacattg 2878141 cacgagaaat ttgaagaact ttatgaccat gcggctgaaa cagtggatac catcgctgag 2878201 cgcctgctgg cgattggcgg acagcctgtt gccacagtga aagaatacac tgagcatgca 2878261 tctatcacag acggcggaaa cgaaacatca gcatcagaaa tggtacaagc attggtaaac 2878321 gactacaaac aaatcagcag cgaatctaaa ttcgtgatcg gcctggctga agaaaatcaa 2878381 gacaatgcga cagcggactt gtttgtcgga ttaattgaag aagttgaaaa acaagtgtgg 2878441 atgctttcct cttatttagg gtaacaaaaa agctgaacct taatcgggtt cagctttttg 2878501 ttttttctta gcttgaactg ctttctgtct gcttggtcag tgttgcgttc aacgttttcg 2878561 tttttccctt tcgcagcact tggattgttg ttttatctcc gacttttaag tctttgtaaa 2878621 ggatctgacg gatatccgca ctgctttcca cgtctttacc gtttagtttg acaatgacat 2878681 cctcagattt aatacctgct ttttctgccg gcgaatttgc ttgaacttct tttacataaa 2878741 cacctttgcc caattgatct ccaaacaggc cgagcgtatt ttcctgatag gtttcaggaa 2878801 cttgtgacat gtcaatcatc tgcacgccta aaaacggacg gtccaccttc ccgttttgca 2878861 gcagctggtc aacaatcggc tcgacatcat tgcttgggat cgcaaatcca agtgattcca 2878921 cgccgctttc gctcaccttc aagctgttga tgccgatgac ctggccgctt gcattgatta 2878981 atgggcctcc gctgttcccc ggattgatcg ctgcatcggt ttgcagcacg ttcatttcca 2879041 ccgtcccctg tgttgtatcc acatcaattg tccggttcag tccgctaatg ataccttgtg 2879101 tcactgtacc ggaaaactgc tgtccgagcg ggttaccgat agcgattacc ttttcgccag 2879161 tgcgcagctg tgaagagtca ccaaagctcg ccactttttt tacattcttg ccgctgattt 2879221 ccaaaactgc caaatcagta atggtatcgc tgccgacaag cttggcagtt tccgtttctc 2879281 cgttgtatag cgtaacagtc agcttgttcg cgccttcaac gacatggttg tttgtaatga 2879341 tatacgcttt atcgctgtct tttttgaaaa taacacctga cccggttccg ctttcacttt 2879401 ctgagctgga gcctcctccc gtgccgaatg tgttattttg agaggtttgg atatttgaga 2879461 ttccgacaat cgtaggctct aaatcctcta ccatatcagc gatgtttgat gcgttcgtta 2879521 tcggcgccgt tgtaaaatta tcagactgca cctgtttatt tgcggaagcg gtttcggtcg 2879581 cctgattttg gtctgacggc agataaggcg cgatgccaag catgaggccc ccgccgataa 2879641 taccgcctaa aatcgggctc agccatgcgg ctctccgttt cttttctttt ttcacagccg 2879701 tttcttgctt ttccatttct aaagcagaag ccgtttcctg ccgtcccgct tcatacgaca 2879761 caggcgcgtc aagcaattct tgttcagaat gtccaatcag cttctggttt tctgtattct 2879821 gctgttctgt atgtgaaggt tcagtttgat gttgatcgtt ttggccatca cgtcgataat 2879881 ccatgttctt acactccttt aacggttatt catttatcgt tacatattca tcgcatgtac 2879941 aagttcaatt gtcccaataa tgaggagaaa agcaaagcac caaaatagaa tatgtttgat 2880001 catcctacat cttcctcgct ctttttctct tcctttcttc ccttaaccat atcataaaca 2880061 aacattgtgg gataaaaatg aaaagaatat gtgaaattat gaaaattgcc tgccgtatgt 2880121 taaaactagt ttataatgac gttgaaagga tgtgaagagc cttgtcatac accatttatc 2880181 tagttgaaga tgaggataac ctgaatgaac tgctgacgaa gtatttagag aatgagggct 2880241 ggaacattac atcttttacg aaaggtgaag acgccagaaa gaaaatgaca ccgtctcccc 2880301 acctatggat tctcgatatc atgctgccgg ataccgacgg ctatacatta ataaaagaaa 2880361 tcaaggcgaa agatcctgac gtgccggtca tttttatttc cgcccgagat gcggatattg 2880421 acagagtgct tggcttagag cttggcagca atgactacat ttcaaagccg tttttgccgc 2880481 gggagctgat tatccgtgtg caaaagctgc tgcagctcgt atataaggaa gctcctcctg 2880541 tccaaaaaaa tgaaattgcc gtctcctcgt atcgggtcgc tgaagacgcc cgcgaggtct 2880601 atgacgaaaa cgggaatatc atcaatttga cgtcaaagga atttgatctg ctgctattat 2880661 ttatccatca taaagggcat ccatactctc gtgaggatat cctcctaaaa gtgtggggac 2880721 atgactactt cggaacagac cgggtcgttg atgatctcgt ccggagactg cgcagaaaga 2880781 tgcctgaatt gaaggtggag acgatttacg gtttcggcta caggatgatg tcatcatgaa 2880841 aaacaagccg ctcgcgtttc agatatgggt tgtcatatcc ggcatcctgt tagcgatatc 2880901 gattttactg cttgtgttat tttcaaacac gctgcgagat tttttcacta atgaaacgta 2880961 tacgacgatt gaaaatgagc agcatgttct gacagagtac cgcctgccag gttcgattga 2881021 aaggcgctat tacagcgagg aagcgacggc gccgacaact gtccgctccg tacagcacgt 2881081 gctccttcct gaaaatgaag aggcttcttc agacaaggat ttaagcattc tgtcatcttc 2881141 atttatccac aaggtgtaca agctggctga taagcaggaa gctaaaaaga aacgttacag 2881201 cgccgacgtc aatggagaga aagtgttttt tgtcattaaa aagggacttt ccgtcaatgg 2881261 acaatcagcg atgatgctct cttacgcgct tgattcttat cgggacgatt tggcctatac 2881321 cttgttcaaa cagcttctgt ttattatagc tgtcgtcatt ttattaagct ggattccggc 2881381 tatttggctt gcaaagtatt tatcaaggcc tcttgtatca tttgaaaaac acgtcaaacg 2881441 gatttctgaa caggattggg atgacccagt aaaagtggac cggaaagatg aaatcggcaa 2881501 attgggccat accatcgaag agatgcgcca aaagcttgtg caaaaggatg aaacagaaag 2881561 aactctattg caaaatatct ctcatgattt aaaaacgccg gtcatggtca tcagaggcta 2881621 tacacaatca attaaagacg ggatttttcc taaaggagac cttgaaaaca ctgtagatgt 2881681 tattgaatgc gaagctctta agctggagaa aaaaataaag gatttattat atttaacgaa 2881741 gctggattat ttagcgaagc aaaaagtgca gcacgacatg ttcagtattg tggaagtgac 2881801 agaagaagtc atcgaacgat tgaagtgggc gcggaaagaa ctatcgtggg aaattgatgt 2881861 agaagaggat attttgatgc cgggcgatcc ggagcaatgg aacaaactcc tcgaaaacat 2881921 tttggaaaat caaatccgct atgctgagac aaaaatagaa atcagcatga aacaagatga 2881981 tcgaaatatc gtgatcacca ttaaaaatga cggtccgcat attgaagatg agatgctctc 2882041 cagcctctat gagcctttta ataaagggaa gaaaggcgaa ttcggcattg gtctaagcat 2882101 cgtaaaacga attttaactc ttcataaggc atctatctca attgaaaatg acaaaacggg 2882161 tgtaacatac cgcatagcag tgccaaaata gactgtagat gttttgcagt ctattttttt 2882221 atgtgaaaga atagccgtta aaatctctgt aatttgtttt gagcggctgt ttgcattgat 2882281 gaacccattt tttctctgac aaggtctgct tcggatattt gactttctcc actttgattc 2882341 ctctgtttcg caagcggctg atcatttcgt ccaattctct cattctagat tcaccctttc 2882401 gcttgagctt tgaccattcg gtcatctcaa tttataatat aaataataca tgataaaaaa 2882461 acaagttaca ataaggttaa ttttataaca gacggtgtga ctatatggtc atatcctagc 2882521 aggcctccgg gctccgaaag ggtggaacca ttgaaggaaa aagaaaaact gattattgaa 2882581 acagccttaa aactatttgc ccaaaaagga tacaactcaa catcagtcca ggaaatcgca 2882641 aaagaatgca aaatatctaa aggcgctttt tatatttatt ttccttcgaa agaagcgctt 2882701 cttctctcta tgctgaacta ctattatgat aaaacgttta cccgaatttt aaatattaaa 2882761 acgaagggcg acagccccag aacggcttac cgtaaacagc tgaccgtcct ctatgaaaac 2882821 attcttgaac acaaagattt tatcagcatg cagttgaagg agggttctct gccttacaca 2882881 gaagaagtgg agcaatgcgc aaaaaaaatc cgccagtcct cacttcaatt tcatatcgac 2882941 agcctgctga acatctatgg aaaaaaagcg gaaccgtaca ctgctgagct ttgtttttta 2883001 atagagggca tcagccagat ttacctggaa tgcatgattt tgctcgggta cactgtgaag 2883061 ccgtctcaat tagctgatat cattatgaat cgaattgatg atatggtaaa aggcatgtct 2883121 gaacgaaacg ataagccttt catcacattg gaagaggcga gctctttatt cggacctctt 2883181 acgcacggac ggcctgaccc gctgactgaa tcaattgtga aaagcctacg tgacaaaatt 2883241 aacagcttaa acacaaactc ctctcttgaa ttatcggaga gcttggacat acttgaagca 2883301 gaaatgaaga aaaaaacacc gaagctggcg atcataaaag gaatgattca taatctgacg 2883361 gagtctgaag ctctcgccaa agatgcggaa cagcttaaat atttattaaa acagcaacat 2883421 atttagaaga acggctgctt aaaaagcagc cgttcttcct attacgcctt tggttttacc 2883481 atgtcttccg gcttaaccat ttcgttaaat tgctcctctg tcagcaattc aagcttcaaa 2883541 gctgcttctt tgagcgtcaa tccctcttta tgggcaagct tggcgatttt cgccgcgttt 2883601 tcataaccga tatgcgggtt cagcgccgta acaagcatta atgaatttga caggttttcc 2883661 tgaatggttt ctttattagg ctcaataccg acagcacatt tatcatggaa tgaattcatg 2883721 ccgtcactga gcagctgcac agattgcagg aagttgtaaa taataacagg cttaaacacg 2883781 ttcagttcaa agttcccctg actcgccgca aagccgattg tcgcatcgtt ccccatgatt 2883841 tgcgctgcga tcattgttaa cgcttcgctt tgtgtcggat tgactttacc aggcataata 2883901 gagcttcccg gctcattttc aggaatgacg atctccccga tgccgcagcg gggtccgctt 2883961 gcgagccatc tgacatcgtt cgcgattttc attaagtcag ccgcaagcgc ttttaatgcg 2884021 ccatgcgcat aagtgatttc gtcatggctt gtcagcgcgt ggaatttatt cggcgagctg 2884081 ctgaacgttt ggccggtcag cttagtgatc tcttctgaga caagctctcc aaactctggg 2884141 tgggcgttga tacccgttcc gacagccgtt ccaccaattg caagcgcacg cattttatct 2884201 gtcgcttcca aaatcatttc cttcgaacgg tccagcatgt gaacccatcc gctgatttcc 2884261 tgtccgaggg tcagtggcgt agcatcctga agatgcgtgc gtccgatttt gacaatatca 2884321 ttgtatgctt ttgctttttc atccagtgta ttgcgaagct gatcaagcgc cggcacaagc 2884381 tgctcgtaaa cagccaaaac agcggcaaca tgcatcgcag tcgggaatgt gtcgtttgag 2884441 ctttggcttc ggttcacgtc atcatttgga tgaatcgttt gatcagagtt cttctctttt 2884501 aataaagcag tcgcacggtt ggctaccact tcgttcatgt tcatattgct ttgtgtgccg 2884561 cttccggtct gccatacgac aagcgggaag ttgtcatcgt acttgccttt gagcacatca 2884621 tcacaaaccg ctgcaatcgc ttctgctttt tcagcgtcca gattgccgag gcgtttatta 2884681 gctagagcag tgcttcgttt taaaattgca aacgccttca caacacgcat cggcattttt 2884741 tcagaaccga tcttaaagtt ctccttgctt cgctgtgttt gggcgcccca aaatttatca 2884801 gcaggaactt ttacttctcc catggtgtct cgttcaattc tgtattccat ttatgtatcc 2884861 ctccataacg gttgcttcaa tagatcataa ttcgccaatg acacaaaaaa tcctttttat 2884921 ttttcgatct tggcagattt taattttaat tcaagatata cgcgggaatc ctttgaatat 2884981 ttgtattttg gatttgtcct gccgtactcc tttgatgtat aagagacatc ataatgctgt 2885041 tcaaatgatc taatgagctg ttcaatttct tcttgttttc cagctagcct tacctgtgcc 2885101 acttcgtatc ctccgctttc ataaaaaaac ttactccatg aaatactcta acacagtata 2885161 tcattttttt aacaggaaaa gataacctct actaaggttt tggataagag gtgacctcat 2885221 tggaacaaac agagtttaag gaatatatac acgataattt agcattggtg ctgccaaaat 2885281 taaaagaaaa cgatgatctg gtgaaaaaca aaaaaatgct tgcgaacgga ctggtttttt 2885341 actatctcta tttcagtgaa atgactgatg agaataaggt gtcagaagcc attaaaactt 2885401 tgattaaaga tgaggagacc ttaacgcttg accaggtcaa aaaacgcctt gaccagcttg 2885461 acgcaagacc tgttgaaact gcaaaaaaaa cgattgaatc gattctcaac ggcaattgtg 2885521 ctgtgtttat caacggattg gataaagcct atattctgac cacaggaaag aaaaaaacaa 2885581 gaagcctgac agagccgaca actgaaaaag tggttcgcgg cccaaaagta gcgtttgtag 2885641 aggatattga tacaaatctc gctctgatca gacaaagaac ctctcatccg aaattgatca 2885701 ccaaaaaaat catgatcggc gaaaacaagc tgaagcctgc agccattatg tacattgaag 2885761 gcaaagcaaa aaagtccgtc ataaaagaag tgaaggcgcg gcttaaaaat atccagctgg 2885821 aagatatcca ggacagcgga acgctcgagg agctcattga agataataaa tattcaccat 2885881 ttccgcagat acaaaatacg gaaagacctg acaaagtatc ttcagccctg tttaacggcc 2885941 gtgtggcaat tttggtcgac agttcaccat ttgtgctgct ggtgccggtt tctctcggca 2886001 tcctgatgca atccccggat gactactatg aacgctggat ttcagcatct cttatccggt 2886061 cgctgcgctt tgcttctatc tttatcacct tgtttttgtc atcgatttat ataacacttg 2886121 tttccttcca tcaggggctg ctgccgaccg cactcgccgt cacgatttcg gcgaacaggg 2886181 aaaacgtgcc gttccctccg atatttgaag ccctgctgat ggaagtcacc atcgagctgc 2886241 taagggaagc cggactgcga ctccccaatc cgctcggaca gacgatcggc ctcgttgggg 2886301 gcgtagtcat cggacaggct gctgtagaag cgaatctcgt cagttcgatt ttggtcattg 2886361 tcgtcagtgt cattgccctg gcatccttta ccgttcctca atacggaatg ggtctgtctt 2886421 tccgggtgct gcgttttatt tcgatgtttt ccgccgctat tttagggcta tacggcatta 2886481 ttttatttat gcttgtcgtt tatacgcact taacgagaca aacgagcttt gggtctccgt 2886541 atttttcgcc aaacggattc tttagcctga aaaatacgga tgactccatt atccgtctcc 2886601 caattaaaaa caaaccaaaa gaggtgaata atccaaatga gccaaaaaca gactccactg 2886661 aaacttaata cctttcaagg tatttctatt gttgcaaata caatgcttgg ggccggactt 2886721 ttaacattgc cgcgagcgct gaccactaag gctaatacgc ctgacggctg gatcacgctg 2886781 atattagaag gtttcatttt tattttcttc atttatttaa acacgctcat tcagaaaaaa 2886841 catcaatacc cttcactctt tgaatatttg aaggaagggc ttgggaaatg gatcggcagc 2886901 atcatcggcc ttttgatctg cggctatttc ctcggcgtag ccagcttcga gacacgggca 2886961 atggctgaaa tggtgaagtt tttcctgctg gagagaaccc caattcaagt cattatttta 2887021 acgtttattt gctgcggcat ttatttaatg gttgggggct taagcgatgt gtcgcggctg 2887081 tttccctttt atttaacggt aaccattatt attttgctga ttgtgttcgg gatcagtttt 2887141 aaaatttttg atatcaataa tttgcgtcct gttttaggcg aaggccttgg acccattgca 2887201 aactccctta ccgtcgtttc catctctttt ttaggaatgg aagtgatgct gtttcttcct 2887261 gaacatatga agaaaaagaa atacacgttc agatatgcgt ctctaggatt tctgattccg 2887321 attatcttat atatccttac gtatattatc gttgtcggag ctttgaccgc tcccgaggtg 2887381 aaaacgctga tttggccgac tatttctctc tttcagtcct ttgagcttaa aggcatattt 2887441 attgaacggt ttgaatcctt tttactggtg gtctggatta tccagttttt caccacattt 2887501 gtcatttacg gatactttgc cgctaacggg ctaaagaaga catttggatt atcgactaaa 2887561 acaagcatgg tgattatcgg cataacggtc ttttattttt ctctctggcc ggatgacgcc 2887621 aatcaagtca tgatgtatag cgattatctt ggctatattt ttgtctccct gtttctgctt 2887681 ccgttcattc tctttttcat tgtagctctc aagaggagga ttacaacaaa atgaaaatcc 2887741 ggattttatg tatgtttata tgcaccctat tgctgtccgg atgctgggac agtgagaata 2887801 tcgaggaatt aagcttagtg atcggaatag ggctagacaa gcctgacgat gaaaatttag 2887861 agctgacaca gcaaattctc gtgccgaaaa taatcagcgc caaggagggc tcttcatctg 2887921 atccgacaca gctttctatc acaaagggta aaactgtcca tcaaatgatg agaacctctg 2887981 cattaaagca taagcctacg ttttcacagc atttgcgtct cattctgctt tccaaaagcg 2888041 tgattgcgga tcaaattgga atggacgcca ttattaacca gtttgtcaga gacaacggaa 2888101 caaggaggag ttcctacgtc tttatcacca acggccgaac taaggatata tttaacatga 2888161 atgatgaagg cgaacccgca tccaacgtga tatatgatct gacagagaat aataaggtga 2888221 cgatcagaac gatggagcca gttacattgg gggagatctc agaacactta acctctgacg 2888281 attcattcct catccctcat gtcggtaagg aaaacggcaa gctcgcgata aacggagcct 2888341 ctatcataaa aaataaatta tggcaccggg acctcacccc gattgaggtt caaaatatca 2888401 gcttattttc aggcactgtc gagggaggcg tcattgactt gaagcgcgat ggccatctct 2888461 tttcttatga agtatattca agcaatcgga agatcaagac ggcatacaag gacggaaagt 2888521 tcaaattcac cgttacccgc aatattgaag gtcgtctatc tgaggactgg aatcccaatg 2888581 aagactcgtt taaggattca tatattaaaa gtattgaaaa gacagtcgaa aaacgagtac 2888641 acgaaacagt aacgtcattt attacagaga agctgcagaa agagatcaaa gcggacgtaa 2888701 ccgggctggg aaacgaggtc agaattcatt atcctcaaaa gtggaaaaag atttcaagaa 2888761 aatgggatga tgattatttc agcaatgcgg aaatagacta ccgggtcaat gtgattgtca 2888821 gagacttcgg aacgaaaggc gcaaacaaat agcagccgcc taattcacga gatgatttcg 2888881 gtgtgcgtac accgccgcct gcgtccggtc actgacatcc agctttgata aaatattcgt 2888941 aatatgtgtt ttgactgttt taatcgtaat aaacagttcc tcgcctattt ctttgtttgt 2889001 ctttccttct gcgatcaggc agagtatttc gagctcccgt tttgtaagcg attcatgcgg 2889061 gagcgcgttt tcacctgagt ggcgcagcct ggataatact tttcccgcca cttttgactc 2889121 cagcttcggc tctcccttgc ttgcggcgcg gatggcatcg gcgatttctg ccgcttttga 2889181 ggttttcaac agatagctga gcgcgccagc ttcaataacc gggtacactt tgtcatcatc 2889241 aatgaagcta gtgagcacaa taattttcgg gtcggaaagc tcccggcaaa tttgctttgt 2889301 agcttcaatg ccatccatgc cctccatgac aaggtccatt aaaatgacat caggcgacag 2889361 ttccacagca agccgaacac cttcgctgcc gtccgatgct tcgccgatga cttcaatatc 2889421 gggctgcgcc tccaaaaaag ccgcgagccc cattctgacc atttcatgat catcaatcaa 2889481 taatactcga atcacgttcg ttctctcctt tttcttccgg aaaaatcggg accttcactt 2889541 cgatttgagt gccttttcct tctactgaaa tcacttcggc gacaccgccg atttcacttg 2889601 cacgttcttt catagaattc aagccgtatg aggaggcttt cacctggtcc attttaaagc 2889661 cttttccatt atcaatcacc ttcagacgga gctggctgtt ctttatgccc agaatcacgg 2889721 ttacttttga cgcttttgaa tgtctaaata cgtttgaaag ggcctcctgc acgattctga 2889781 acaagtggtc ttcaacaccc ttggatatcg ctgtgtcctg tatatcccac tcaatatcaa 2889841 tcggctgctt ttttcggaac tcgtccaaaa gctccgtaag gccctccttc agcccttttc 2889901 cttcaagggt aacaggccgt aaatggagca gcagcgccct catctcattt tgggcttcgc 2889961 ctgccatatg ctcgaccatc ctgatccgct tgactgtttt gtcatcagca tccttgacat 2890021 gttccagcac ggctgatgtc atcatcgata tggcaaagag ctgctggctg accgcatcat 2890081 gaagatctct ggccaatcgc tggcgttctt ctgagataac cgacttcttc atttgagcct 2890141 gccattccgc acgttcattg gaaagtttct ggagggatgc gacttgaagc tccacgcgct 2890201 tcgccatttc gttcagctga tcagcagcca ggccgatttc atcatcaccg agcggcggta 2890261 tccgataagc gaaattgccg ttttcaaagg ttaaaatgga ttcaattaat gtatcaatcc 2890321 ttgtcttcaa ccggttgccg tacatatacc ctgaggcgaa accgacggtc acgctgatca 2890381 gaagcaaaat caggataaac ggaattccga accagcttga tgacagcaaa acaagcggat 2890441 cgagccgata gtaaaacatc ataaaggaaa tcaggcaaac aaaaaggagc aggctgattc 2890501 ccgttgtcat gcggatggcg cgccattgga ggctggcaag catttttttt ctcatacgta 2890561 cttcacatcc acatcaccga taaataagga aacggacact tttacccggc gctttgactc 2890621 gctaaaatca gttgacgcgg catatacctt cgtgcttaat ccgcttttct tcgagccgat 2890681 cagattaatg tctcctataa aaacagccga gctgacagcc acttcaaggt ccgatggtac 2890741 ataaatatca acgttaccaa tgactccgct aatgacgatt gtactttctc cctcgggaat 2890801 catcgcttta gataaatcga ttttgatatc accgataaaa ccagagacat ttaaatcgtt 2890861 caggtcaaac ggctgcttca tcatttgcag ctcaccgata aaaaagctgc gcatgtcggg 2890921 atgttttaca tcttttggcg gctcatgatg ttctttttta ttgagattga cctgtttctc 2890981 attcggttca aatatcggct tccctttgat aagcctgtag ccggcgtaaa tcagaaatgc 2891041 ggcaaacgca tagccgaata aattaaaggt gatgctgaag aggtttttca aaaatagaaa 2891101 cgcggcaaag atatacatga cggagccaag ccaatcacgg gaatattttt taaggaaata 2891161 gccggcaatc agaaaaaaga gcggccaaaa cagcagatcg cctattccga taatttgcaa 2891221 aaacatactg atgccgaata aagcaatgat caatccgaga agctgttttt ttgtcattcc 2891281 tggtgtccgc ctcctttctt ctgcctagtg ctaccgtatc gctagatccc cgctgtccgt 2891341 tttgatgtcg attggatgcc ggccgcttcc ttgcgtgcct gtgatgtgat gctgttcttt 2891401 atgtccttta tcagcaaatg aatacggcga actgacgtca ccgcttgctg ataaagcatt 2891461 gactgcaaag ctgccatttt ggggaaggct tacattagca tcaccgcttg tcagcgtgac 2891521 agatacggga ccggttacct ttttcaatac agcattaaaa tctcctgaag tcattttcac 2891581 atcaagagag cctgatacat gaaccagatt tgcgtcccct gaagctaaat caatgccggc 2891641 tgttttggag acggtatttg aaatggaaac atcccccgat gatgccttca ctttcagatc 2891701 ttgaatgcgg acgtccgtca cgctcgtatt tccgctcgca gatactgcgt tcagcccgga 2891761 aagcgcaaga tggtcattcc cggccacaga cacgtcaccg cttgaggttc gtactgccag 2891821 atcaccttta taatcatacg gaagcctgac gataagagtt gaacggttaa atccattcaa 2891881 aaattgaaat tctttttcct ttacggtcag ctccagtttt cttttgtttt cagtaacaaa 2891941 taactttcct gagtctcctg aaatgcctgc cgatatgtca cttcgttctt ccgctataat 2892001 ccggacatcc ttgctatccg actcaatgac catgctgtca atgtcccgcg gcgatgcgct 2892061 ggctgaatca gcttctgtgc catttatgaa acctaggcct gcagcaaaca catcttttac 2892121 gacgacggcg aaaaaaacca gaataccggc agtgatcaac agtttgccaa gcattttttt 2892181 cattcggttt catccttctc attcattcta ttataaagga aaagcttgcg aattgatacg 2892241 tgcggaaggg aaggacttga ccgcaaatcc ttccccgttc cgcttattca tttgccgctt 2892301 ttgtctggtc tgatttttgc agtgaaagtg tccgcatttt ttcaatctcc gcttccacat 2892361 cgtctgcgaa ttctttacgt gtaagttctg tgccggcttc cgctgacttt gaataattcg 2892421 cgcggatttc catttcttca atacgatttt caatacgtaa aaattcacga tacgcgcttt 2892481 cactgtcaat tttgtcaaat gtcgtattca tatgctcttt agctttcgcc gcatttgccc 2892541 gcgcaatcag cgcctgtttt ttatccttta cgtcctgaag ctttgtttca agtgcagcca 2892601 gctgctcttt cagatcagcc agctgactgt ttgcctgttc ataggaagct ttatgctcag 2892661 ccgccttccc ttctaaatac ttcatttcag tcagcgcctt tttcgccagt tcttcttcac 2892721 ctgcgtcaaa tgcgagctgt gcctgatttt tccgtttgcc agccacttca gcggcttctt 2892781 catatttttt cttaaattga taggcaatcg tgtgctgttt cacaattgtt tgctttgctt 2892841 ttgcgatgtc gctttccata tcgcgtacat attgattcag catcaccttt ggattctcca 2892901 ttttatcaag tccttcatga actgacgcaa caaacatgtc tctgattctt tttaatacca 2892961 tacctgattc ctcctaatat attgatatta ttttttcttc aaaaattctt cccattcgtc 2893021 atcaaagtga gattggtagg cagcagaagc cggttcagga tcaaaagatg atacaccgtt 2893081 atcagctgat ccgtttttca tcagcttcca gccgtaatac accatagcgg ccgccaatgc 2893141 gattccgacg acaaacggaa gtgagcagat gagcataatg gctccgatac cgcccacgat 2893201 gattcccgtg atggtttttc ccgcggcaaa ccttttgatt cctgcgtatg tcatcaagct 2893261 cccgatggcg agcgggatga taaagccgaa gcttcctcct ccaaaaaaga cggagatccc 2893321 aaatacaatt aataagaatc cgcctattgt tttcttgttt attttcatgc agatcctcct 2893381 ttcgttttcc ttgtcttcat cttatacaag ttggaagata tgcaaaacga atcagagatt 2893441 gatttttata taagaccgga gtcgtatctc gcaccggacc cattggcaca aaaaaacgcc 2893501 atgcacgagg catggcgttt taaaaccctt tacagatgaa cacttgcttc cctttcttta 2893561 attaggtcgg acctttctgc tttggccaat tttgtaaaca gcaagattcc gatacccgca 2893621 ataatttcga caatcccacc gacagcgatc actttacctg agccgaaagc attagcggca 2893681 tacccgcaaa tgacagctcc ggcagggatc gaaatatttg agatcatatg tataacggcg 2893741 taaacctgcg gctgatcctc actatccaca gacgtctgga taatcgtgta ctcaggaaca 2893801 ttaacagcac tgactgcggc accaaaggta aaagcagcga aaaagacgag cggcaaaaag 2893861 gtattcatcc cggtaataaa gaaagcaaat ccttcaataa tgccggcagt gacgaataac 2893921 aagccgtacc tgtttacctt gactttcgcc agcacaaacc ctaataaaaa cgcgcccgcg 2893981 gcggtggtgg cctttaaaag cgagtatacg atcggctggc cgtttaaatc ttccgcaacg 2894041 tatacggcag agagcgcttc ccatggggca gccgcgaaat tcataaagat acagtaaatg 2894101 gcgagcggat ataaaatctg gtgttttctg acgagcctaa agccgcgttt cagtcttccg 2894161 atatatgtgc ctctctgtgt aacaaccgca gactctgatt gagattcaac cgcagtgtac 2894221 ttaataaaaa gaacgagaaa acctgacacc aaatagagca caagtgcgat aagcatggta 2894281 taagaaggac taataaatgt aagaaaagcg ccgcataatg tgacagcccc aagccggaca 2894341 atttgagcgg aggattgcag cacagcgttt gctttttgaa tgccctgttc attgacgatt 2894401 tgaggaatca aagcgataga ggcgggattg taggcagctc cagtagctga atgcacaatc 2894461 ataagcgtca tgacaaacca cagcggagag aagcccgcaa aatgacatag agggataatc 2894521 aaaacaatcg ccgcccttgt cagatctgaa aagtacatcc aaaatttcag cgtggtctgt 2894581 ttcataaaag gccccgtcac aggcgccaga acggcttccg gcaaaaacgt gacagcaatc 2894641 aataaagcag tgccgatcgc acctttgccg tcataaatta aaaaccataa tattgaatta 2894701 aatgcgaaca tatcgccgga tatcttgact attcttgaga aaaacagata attgaaattt 2894761 ctcttccaga tgctatcact ttcaattaaa ttcaccatcc atcagagccc cccgttgcct 2894821 attttttaca tctatttatt acaatatctc atttttccat ttttcagtca ataattcata 2894881 aggttcattt tttgtcgtaa aatgggaaat tgacagagtg aaaaacaaaa aaagccggca 2894941 tgtatttgaa cacgccggct ttccttttca ctttttatga ttcgctgctg tttcggtccc 2895001 gaaacacaat ggcacttctt tcatattcta catcgccaat accgcttctt gcattcacaa 2895061 cccgggcggc ggcaaagaaa taatcggaca gacgattgag ataacgcagc actgtttcat 2895121 gaatctcctc cgatttcatc agcgccacca ctcttcgttc tgcccgcctt gtaatggtgc 2895181 gtgcgatatg gagaagcgaa gcacactttg atccgcctgg aagaataaat ttcttcagtt 2895241 ccggcgcttc tgctgtatag gcatcaatgc gcgtttctaa aaaggaaaca gattcttccg 2895301 ttagtttata gtcttttctt tctgtgacga ttgccagatc gcctccgcag tcaaacagct 2895361 catgctggat ggtcagcagc tcggctgtca gatcttcaaa gccgggctgc ccggaaagct 2895421 ctgccaaagc aagcccgata aagctgttaa gctcgtcaat cgtgccgtag ctttcgacgc 2895481 gtaggctgtc cttgtccgtt ctgcccccga ctaagcccgt ttgtccctta tcgcctgttt 2895541 ttgtatatag tttcataccc tgaatctcct ttacagactt attcaaacaa ctcagcagcc 2895601 tcttttatac attcagctgt ccctttcttt atcaattggt tcagccgctg ttctatgttt 2895661 tctgattgct gagtttgagt cgcggcgatg agaatatcac ctgtgcctcc tccgtctccc 2895721 agcactttcg tccgttctgc ttcggcagcc ataagagctt tgatgaagaa ttgatctgcc 2895781 gcatagccgt taatcaaaat ccaaatcgaa aagccggtct gaacgcatat gaaaacggat 2895841 aactctccgt cttcatatgt tcgatacacg aaacggtcaa gtctttctga agaagccatc 2895901 gcacacgtct cctgcagttg aaaaccgctt tctgaaagac aggccgtaag tccttctatc 2895961 ggatctggct gatctggcag ccgtttatgg atcagcgtcc tgctccacga aaaccctgca 2896021 ccgataggcg tggaggacaa tgttcgaagc gggatttccg tttgcagaag aatgtcatca 2896081 cgccccgctt ggagcaatgc ttcaaatggg atagactgcc gcttcacgct atctttttca 2896141 ggctgaatca caatcatcgg tttaggtgag ctttgatgaa ccaaggcggt gacatctgta 2896201 tcgtacaccg cctttatgct ttgttctgta acagcatatt ccggtttttg cttaggcccg 2896261 gcggtaccgt ttttcataaa catgagccca tcacagtaca ggcttgcggt gttcagatca 2896321 tgaaaaacgc tgacagctgc caatccgctt tctctcgtca ggcgtttgat cagatcaagc 2896381 aggtcttttt gataagccag atcgagaaaa ttagtcggct cgtccaaaaa taaaatacgc 2896441 ggctgctgcg ccaaagcttg tgccaaatac acccgctgct gttcccctcc gcttagttcg 2896501 cgaatcggct tttgcgcaaa atcggccact cctgtttgct ccattgcttc ctgtacaatg 2896561 gcttcaccct tttcagtctg ctgtctgaac agccccgttt ggaatggata tctgccaaag 2896621 gctacagttt cttcgacagt aaaggtgaag gcttgatcca ttttttgcgg caggacagcc 2896681 atgatttgcg ccagttcctt cggtttatag tccgccagca gttttccggc cagataaacc 2896741 ctgcctttct tggccggcag cgtacctgtc agcaagtgca aaagcgtggt ttttccgctt 2896801 ccattagggc cgagaattcc aagaaattct cccttctcca ctgttaagct gacattgttg 2896861 attaggcggc tgtcgccgta tcctcccgac agcccttctg ccttcatcat aagcttctcc 2896921 ccccgcgatg ctgccgaatt aaaataagag cgaacacagg cgctcccgcc aaggacgtaa 2896981 tgatcccgat cggcagttca atcggctcaa tgatggttct ggaaagcaga tcggctaaaa 2897041 caagaaaccc tgccccaagc aaggcggaca acggcagtaa atgccgatgg tccgttcccc 2897101 acaaaagcct tgtgatatgc ggaatcacaa ggccgacaaa gccaatcgta cccgatactg 2897161 ccacagcgct tcccgtcaaa agagatccgg ctattaaaat catcatcttc ctctgctgaa 2897221 cgctgactcc aagaagcttt gctttatctt ctccatatgt catcacgttc agttcccttc 2897281 cgtttataat caataaaatg gttcccaaaa gaaaaaacgg gagaaacaaa ataacatagc 2897341 tccagcccct cattgagacg ctgccaagca gccaatgcac aatcggaagc aggttgtctc 2897401 ctgtcaaggc gatgataaga gaaataaatg cgcctaaaaa agagttggtg atgacaccgg 2897461 tcaaaatgag ggtggaaaca gacatcgaag catgaacgag gcggctgaag aaaaggaccg 2897521 ccgccatcgt ggccagtgcc gcggctacac tcaaaaccgg gagtgtaaac cctccgatga 2897581 caggaaggtg caaacctaag aacagagtca caacagctcc gactgaagca ccggatgaca 2897641 cacctagcgt atagggatca gcaagcggat ttttcaacaa tccttgaaaa gcggcccctg 2897701 caatagaaag agccgccccc acaagggcgg ccagcacaac tctcggcagt ctgatattca 2897761 tcataatatt agtgtacatc ggatcatcag aaccgataga gccgccgaaa ccttgatgcc 2897821 aaaagacacg aaaaacagcg ggaataggaa tatgcaggct gccgcaagaa attcctaaga 2897881 tgatgctcac ggctaaaaat gagaaaccaa tgatatatgc ggcataacga ttattcctta 2897941 aacgtatccg ggtaaatgct ttccgcaagt tcttcgaccc cttcgatcag acggggaccg 2898001 gaacgtgtca caagatcagg gtccacatca tatacacgat gatgtttcac agcattgatt 2898061 tcgctccagc catcgcgttt ttccacagct ttcgctttca caccgtccgt tgtaacaatt 2898121 gcatcaggat tgagttttac gatcgcctcg tctgtcattt gcacccatcc tgtctgatcc 2898181 gcagctgcgt ttttagcatg gatgacattt agcatttcat tcataaacgt atcttttccg 2898241 gttgtataaa tgtcaggatc aggagaaacc tcgataaata cgcttttctc ctcgtctttt 2898301 gaaatggttt tcgctttttc ttgaatatcc tttagatctg atttcatgct tttcacgagc 2898361 tgatcggctt ttttctccgc cccgccagct tctccgatca tttcgattga tttgtacacc 2898421 tcggagaatg attgtgcatc attgacagtc agcactgtaa tgcccgcgtc cttcagctgt 2898481 ttgatggcat ccgctgatgc tgacatggaa gactcatggg ccagaacgag atctggtttt 2898541 agagaaatga ctttttcaac gtttacattc atatctccga ctttctcaac ctttttgact 2898601 tcctttggat aggtatcgtt tgtggtgaca ccgaccactt tgtcaccaag gccgagtgcg 2898661 tatgtaattt ctgtgttgct cggcattaat gaaacaatct tttttggctc ttttttgatg 2898721 gttacatctt ggtttgacgc atcatcaatg gtgacaggga acacttctgt tttttgtttt 2898781 gcctttgaat ccttctgatc cgcaggattg ccgcagcctg ccagcataac agcagccaac 2898841 agaagcgcag cccatatccc ggctcgtttt ttcataatct tttcctccta aacgaactaa 2898901 aaaagcatct ctacgacggt aaagatgctg taaacaacac aaaaaagcct attgtttaca 2898961 catcatctgt cctcgcagaa ttcgtgctga tcaaacaggc aggtatcctg gctcttggcg 2899021 cttggccaat tacagtggcg ggaccgcacc ggcttttacc ggtttccctt ttaagccggc 2899081 tgttgttcac ggaccggcac ctatttgaca ttcgtatccg tttttcggag taattatact 2899141 atatgactga caggcttgta tatgtgtcct gaatgacttt tccccatatt gtgtatggaa 2899201 gcaaaatcct cgtaaacact aaatttgatc ttgtatactt aataccatca tctatcaaaa 2899261 ggaatgattc ttatggattt acagctaaaa gaaaaactcg tcttaatcac cggctcgacg 2899321 tccggtatcg ggaaagccgc cgcaaaaagc tttctgcaag agggtgcggc agtcattgtc 2899381 aacggacgca aacaggagac tgtcgatcgc accattgaag agctttctgg ctatggaaca 2899441 gtgcacggtg ctgctgccga tttgtcaaaa acagatgaag cagcggcttt tatcgaaaaa 2899501 gtaaatgaaa tcggtgatat cgatatcctt gtcaacaacc ttggtttctt cgaggtaaaa 2899561 gacttcgccg atgtgacaga tgaagagtgg aatcaatatt tcgaagtgaa cgtgatgagc 2899621 gccgttcgga caagccgtca cttccttcca aaaatgcttg ccaaaaacag cggccgcatt 2899681 ttaaatattg caagtgaagc aggcgtcaaa ccgctgccaa cgatgattcc atactcaatg 2899741 acaaaaacgg cactgatcag cctttcaaga ggaatggctg aaatgacaaa aggcacaaat 2899801 gtgacggtca actcagtgct cccgggacct acttggacag agggcgtggc ctcctatatg 2899861 gaaggcgccg cacaagcagc cggacaggat acagatacat ttatcaaaga ctatttcaag 2899921 gtcaatgagc caacctcact tattcagcga tacgcgacag cagaagaagt cgccaacaca 2899981 atcgtattcc tcgcgtctga cgccgcatcc gccattaacg gcacggcaca gcgtgtggaa 2900041 ggcggcatta tccgttctct gtagtataaa aaaacgcatc cgtgtttcgg atgcgttttt 2900101 tttatacgtc tccagcaaat ggtaccggct gatatccgcc tgtttccagt tgtgctgaaa 2900161 acaaccctcc agcgtgaggc tgctcgtatc tctctttttc tgtcatttgt tctgttgccg 2900221 ttgtaatgta aagggttttt aagtctctgc cgccgaacgc gcagcacgtg acatatttag 2900281 ccggcacgct gattgaattg atttcttttt tctgaaacgg gtcaatgtga acaacgcggc 2900341 tgccgccaaa cagcgccacc cacagcatgc cattttggtc aattgtcatg ccgtccggca 2900401 atccgtctga ctgatcaaaa cgatagacag gttctggatt cgaaacatct ccgctttgag 2900461 gatcatagct gtaacgtaca atctcctggg tcggcgtgtc gatgtaatac atcaaattcc 2900521 gctcgcggtc ccaatccaaa ccgtttgagg tggagacttg atccttgatt ttgacaagac 2900581 tgccgtctag attcaaacgg tacagcgacg cctgtttttg ctcgccttcc atgctcgtcg 2900641 tccccgccca aagccttccg tacgggtcac atttagcatc attaaatctc aggctctcat 2900701 gcatgtcctt cggctgttta attttttcca agctgtcatc ccgaagatga tacaggtaaa 2900761 acccgtcctt catcgtcata atcagttcat cctttgaata tttcgcaagc gccgtcacaa 2900821 aggatttgaa tttgattgat cggttgattt tttcttcagg gtcaaagatg tggagctcgc 2900881 tccccaggat atcaacccaa tataagcggc cgttctcttc atcccataac gggccttcac 2900941 caatcactgc ccgagtgtct gcttccaata ctgcatccat gtgttacacc tctttagctt 2901001 cagtctatat attgttattc ccggcaaaga ggtgtccaaa ccacttgatg tttattgttt 2901061 tttaaaaagg atggtaatga ccgttccaat gttcgttctg ctgttcacat ggatcgttcc 2901121 gttatgcaga tggacaagct ccttggcaat cgcgagcccg agacccgttc cggcagttga 2901181 atcttttgtg ttcgtccctc tgtagtagcg gttaaacaaa tgggtgatcg tttcttcatc 2901241 cattcctttc ccattgtcct tcacttttaa agaaatatga ttttttgttt gctccagaat 2901301 gacttgaatc tctgttcctt tgccgttgtg cttcacggca ttcccaagga ggttttctaa 2901361 tatgcgcctg aaccacgctt catcaagggc aaattcaata tgctcttctt tggatacaaa 2901421 cgagatatca tagccttcag aaaacggatt tttcttaaaa tcctcaatga catttttaaa 2901481 aaacgggata aggctagtga gctttctctc aataggaaga gcatcatttt tcaggcgata 2901541 cgttaaattt aagtcttcaa tcagcttaga catgtattca gatttttctc tgacaacctg 2901601 ccccatttct ttcacttctt ccggcgacca gtcatactgc ttcgactcga gcatcatgct 2901661 gtagccgtaa atgctgctga gcggtgtttt taagtcatgt gacaaaccgg caatccattc 2901721 ttcccttgtc gcctggattt tttctctgtt tcttttatcc cttctcagcg tttcagtcag 2901781 ctgatccatt gattcaaata tctcaccgaa gaagcggtac ggctgtttga tttttccctt 2901841 tttatttttg ctgacaggac ggccttcccg gtttctgggc tcctcaagct tcccttttga 2901901 cagattgacc agccatctaa tcgtgtgaaa aatcggcagc ccgaatcgga acatatacca 2901961 aacggtcatc caaatgatat acatgaacaa aacggccatc acgagaaaca tcgcttttaa 2902021 tacaaccttc aggaatgatt tgttaaactc ctgatcggtt acatagactg ggttcggcac 2902081 cgtagcgacc atccatctgt ctttattgag gatcttaacg gaaatttccc gcttatagtt 2902141 ccaaggctta gagctgtatt taagcagctc cagctggttc atcgtttttc tctcgctttt 2902201 tgtgctgttg atgctgtcga gaatctttcc attgctgtct aacaggtaaa tggcgccttt 2902261 tttccgttta atatagtcga tggtactaga cttatagtgc gctagtgagt ctatcttttg 2902321 ttcacgcttt tcaacggaag tcaggagctg ttcacttttt gatttccagc cggacaatag 2902381 aagatacgac ttatcttcaa tattgatggc ccaataattc agtttatagt tatgaagctt 2902441 tttggtttta taaatagaca aaagctcttt cttggtatag gtgcccggca cgtcttttgg 2902501 cacgccgtag gaataatcag tgtttccttc cgaatcaatg atttgcatcc agccgtgctg 2902561 tttatcaaca gatttcttca ggaaattatc cacttcccat gtcccgtctt cgtttacatc 2902621 gagatatgcc tcaagtgtgt cggtcgttgc tttcgtcagc cctgaattgg attccgcatc 2902681 gctaaaacgg gcgtctaaat agaaaaacga tgcaacaagc ataaccgtaa gcagcaggat 2902741 cacaatcagc atctggccga aaaagtgaaa caaaaacttc catcttaacc tcatgaccgc 2902801 ttgccttcag gatttgggat aaaacgatag ccgagacctc gaacggttac aatatactcc 2902861 ggattgctcg gatcgcgctc aatcttctcc ctaagcttgc gaatatgaac catgacggtg 2902921 ttgttgtcac cgtaggaagg atagccccat actttttcat atatttgatc tttggaaagc 2902981 accacgttag ggtgttcaca aaaatactgc aaaagctgca gaagctgggc tgaacaggca 2903041 acggcttccc cgcctacgat caactcggca ttttgcggag aaaaagtaaa gtaatcatat 2903101 gtgtaggttt gatttgaact cgtttctttc gattgatatg tacgcttgag atgcgctctg 2903161 atccgcgccg ctaattccag cggattaaat ggttttgtga tatagtcatc agctccaacc 2903221 gcaaagcccg ataatttgtc cgcgtcggat gatcttgccg tcaggaaaaa aatcggagcg 2903281 tctgaatact ctctgatcaa tgtgcaggct tcaaaaccgg acattccgcc catcatgaca 2903341 tccagcacaa tcaagtcaac cttattggcc ttcacaacgg gaatcgcttc ttctgcgctt 2903401 gccgcatcca gtatatttcg ataaccttct ttttcgagaa cgcgtttgat catgtccaca 2903461 atcgctttct catcgtctac gattaaaatt gacgcatttt ccacttttat gttcctttct 2903521 gtcactgttt ttttcatctt atcattatat cgtttattta tggtacattt ttgaatacat 2903581 tggagccttg gcaaatcaaa acagcaaaaa aggagcaaac aagcgctccc ttttgatgtt 2903641 ttttcatatg aaaatattat gagttctcat ctaccatgta caaaataaac tcccaaaacc 2903701 ccggtacatc ctgacataaa agcatatcag ccttttcaaa cattttgatc ttcagctctt 2903761 gctctaaatc ttctctttct tgataggacg tattgctgag tttttttctg atcatcggtg 2903821 aaaagcatgc aatcaggtgc tcaatgtcat aagtctcgtc tttttgtttc tttttttgtt 2903881 caaactggcc gtccacagct tacttttccc cctttttttg cgccgctaac tgctttctga 2903941 tattctccag ccccttttta tgaatgttgg agatgttttg tcgggactcc cctaatgaat 2904001 ctgcaatctc ctgcatcgtg gcaccgtgaa gatagacttt cgtcagcaca cttttttgtt 2904061 tgtcagtcag cttctggatc gcttggtaga gctggtaatc ctgtacatgc tggctcaaat 2904121 catcctgcct gtctaaaaat tcttcaaatg catcgctacc tgtttcggaa gaaagccgat 2904181 ctcccgcctc cggatgatca accgtcagtg gataccgttt ttggtttttg cgaacccgct 2904241 tatcaaaatc aatagaaaag atgcgaatca ttgaattcat atacttgacg atgcggattt 2904301 ctttataaaa ttgcttaaat agctcgtcca atgatcttgc atctttttcg ttagggcttt 2904361 ccattacgtt tttgaacaaa cggtaatgct gaggattgct caaaaaatgc ttcacgatgg 2904421 gatgcttcat tatctcctta cattttgacc gtaaaagact ttgatagtcc atcaaaccgc 2904481 ctccctacta aattaaatga aggaaagcaa aaaaaagtaa actactactt tccgcctagt 2904541 gtcttccaaa atactttgca gcagtttacg ttttatcggt tttcctcact tacatacatg 2904601 actgcagaaa aagaagggag gtattttcct atggatcagg tttttataga ggaagtcgta 2904661 aaacagatcg gcaatttggg gtttcccgcg ctgattgcaa tgtatctgct gacccgattc 2904721 gaaaagaagt ttgatcaact aatagaacta atgacagaac tgaaagatca tgcaaaaaaa 2904781 taatttttca atcgaagttg acttttcact ggtttttttc acttaacaaa acagaaggga 2904841 aaacgaaagg cctttcacct tctctttctg ctatcacatt taaatgtaag gaggaaacat 2904901 ttcatgaaaa aacaaaatga cattccgcag ccaattagag gagacaaagg agcaacggta 2904961 aaaatcccgc gcaatattga aagagaccgg caaaaccctg atatgctcgt tccgcctgaa 2905021 accgatcatg gcaccgtcag caatatgaag ttttcattct ctgatactca taaccgatta 2905081 gaaaaaggcg gatatgcccg ggaagtgaca gtacgtgaat tgccgatttc agaaaacctt 2905141 gcatccgtaa atatgcggct gaagccaggc gcgattcgcg agcttcactg gcataaagaa 2905201 gctgaatggg cttatatgat ttacggaagt gcaagagtca caattgtaga tgaaaaaggg 2905261 cgcagcttta ttgacgatgt aggtgaagga gacctttggt acttcccgtc aggcctgccg 2905321 cactccatcc aagcgctgga ggagggagct gagttcctgc tcgtgtttga cgatggatca 2905381 ttctctgaaa acagcacgtt ccagctgaca gattggctgg cccacactcc aaaagaagtc 2905441 attgctgcga acttcggcgt gacaaaagaa gagatttcca atttgcctgg caaagaaaaa 2905501 tatatatttg aaaaccaact tcctggcagt ttaaaagatg atattgtgga agggccgaat 2905561 ggcgaagtgc cttatccatt tacttaccgc cttcttgaac aagagccgat cgaatctgag 2905621 ggaggaaaag tatacattgc agattcgaca aacttcaaag tgtctaaaac catcgcatca 2905681 gcgctcgtaa cagtagaacc cggcgccatg agagaactgc actggcaccc gaatacccac 2905741 gaatggcaat actacatctc cggtaaagct agaatgaccg tttttgcatc tgacggccat 2905801 gccagaacgt ttaattacca agccggtgat gtcggatatg taccatttgc aatgggtcat 2905861 tacgttgaaa acatcgggga tgaaccgctt gtctttttag aaatcttcaa agacgaccat 2905921 tatgctgatg tatctttaaa ccaatggctt gccatgcttc ctgaaacatt tgttcaagcg 2905981 caccttgact tgggcaaaga ctttactgat gtgctttcaa aagaaaagca cccagtagtg 2906041 aaaaagaaat gcagtaaata aaagacttgc ggcttgcaga gagcactcgt tctctgcaag 2906101 ccttcataag gagctgaacc agtgaaacat caaaaccctt caaaacgctt attgcggctc 2906161 tccataaagt acttgctggc cgcagcagca gtggtgttga cctattttgc tgtcatctat 2906221 atattgtttt ctttagcggg aacgagctac cgctcagcag ctcatgtcct gctttttgcc 2906281 gtggtattcc ttgttctcgg attatgcttt gaaccatttg aacggctgat gatacatagc 2906341 tttacatttt tcaagacagg aaaacgtcta ttcattctcc ttgctggcat cgtacagctg 2906401 ctgtttttgt ggatgactgc tcatacaaca gaccaattga tcagcgacat ctggctgtcc 2906461 accacagaag aaatgattgt cgcagccgtt tttttgattt tagacaaatg caactcggct 2906521 cttcccagct aaaaaaagaa cgcattccaa ttggatgcgt tctttttatt catagcgaag 2906581 cgcgtctaca ggctgaagct tcgaagcctt gatagacgga agcaagccga agataatgcc 2906641 gactgccatt gaaaagatga gtgctccgac aacagctgga atggagacga taaaaggcat 2906701 cggaaaaatg accgtcagca gcttggcgat gccgaagccc gccagcacac cgagtattcc 2906761 gccaatgctt gtcagcacga cagcctcggt taaaaattga aataaaatca cacgccgctt 2906821 agcaccgagc gctttcttaa ttccgatttc cctcgtgcgc tccgttacgg aaacgagcat 2906881 aatgttcatg acgccgatac cgcccaccaa aagtgaaata ctggcgatac cgccaagcag 2906941 caatgcaaat gactgattaa aggactccac ttcctgcgcg atctcctgaa gatccattac 2907001 actgtactct gctttttcca gctcagcttc tgacagtccc tgatttaaaa gatctgcagc 2907061 cattacaccc gcttcttgga tatgctcaga agaatcagcc tgcacggcaa tctgcgttgg 2907121 cgcgtcaaat ccttcaataa gcggccacac ttttttcggc acgtacaaaa ccgggttcgc 2907181 atagtcgcct tcaaacatgc tttcctgttg atttttttct ttaaaaacac ccacgacctt 2907241 aaacggcaca ccattcatct caatgctttt atgcagagct tctccgtctg gaaacagttc 2907301 atctctgaca gcttcattga tcatcactac ttggtgtgtg ctgtttaaat cgttttccgt 2907361 cagctttctc ccttcggtta ttcggattgg aaacatgtcg aagtaatcat cgtccactcc 2907421 atacacttgg ggatacgaaa cgttagttaa atgaaaaacg ctcgcgcctt ctgacaagta 2907481 atataaggat aatcctttga ccatcggatc tgatttgatc gcctttactg tttcttccgc 2907541 tacaggcggc gcggacgcat acgacacctg agggccgccg ctctcctctt ctccgccaga 2907601 cggctggtag acaacattga tggcgttgtt tcccatgccg atcatacttt gctttaactg 2907661 ctcactttgg cccttcagca ttgaaacaat cgcgatgatt gccgctatgc cgataatgac 2907721 gccaagcatt gtcagaatcg atcttaattt atgagagaaa atggattgaa aggagattcg 2907781 aatatgttca agcatggctg atatcccctc tctcatctaa taccaactct ccgtctctga 2907841 taaaaacggt tctgtcagct tttttggcga cgtccgggtc gtgggttatc ataataatgg 2907901 tcttgccttc ccgatgcagt tcagaaaaca gtgccaaaat ttgttcactt gatttggtat 2907961 caagcgcccc ggtcggttca tcagctaaaa taaacctcgg ctgattgaca agggccctcg 2908021 ctatcgccac ccgctgcttt tggccgccgg acagcttagg cggtttgtag gagaccctgt 2908081 cttttaatcc gactttttcc agcgcttcat atgcccgttg ccttctctct tttttcttca 2908141 ctttattgta gatcatcggc agctcgacat tttgcagcgc ggtgagacgc ggcagcaaat 2908201 gaaaagtttg aaacacaaac ccgattgatt cattgcgaat ttcggctaaa gccccgtctt 2908261 tccctttcaa tatatcgatc tggtcaagcg tataggttcc tgaggttggc ctgtccaaac 2908321 agccgataat attcattaac gttgactttc cagaaccgga aggccccata atagctaaaa 2908381 actcccccgc ctgaacggtc agattgatat gtttcaagat tggaacttct tcttttccca 2908441 gcttgtacga cttcgaaata ttattcagtg tcagcattga ctgtaacctg ctttccttcc 2908501 ttgaccgcgg gatcaggata gatcacataa tcttccggcg tcaggccgct cttaatttcc 2908561 accatgtcat tttcatcagt ctctccgatt tcaacaggct gcttaaccgc tttgtgattc 2908621 tcatcagctt tccatacgta cggttcgccg tcatcctgaa tgaccatgtc ggacggcagc 2908681 ttgatcgtgt ccgcatcagc attatcactc atcacttcga tgttgacatg atagccgact 2908741 tcaagacctt tatggctgtc taataaaatg gtgaaaggat agttagagga ctggggattc 2908801 atttcttcat cagcaaagct ttctgattct tcaccctcgc ctgctcccgc tggaagcttg 2908861 ccgatcgagg tgacctttcc tttccactcg ccctcaccgc ctgttttcag cgtgaccctg 2908921 actttgctgc cttttttgat cgtgtccatt aacagctcat tgatttggct tttgaccaga 2908981 tatttgcctg tcgaaacaat ctggatatac gggcctgctg cctggtcgcc tgttgcaccg 2909041 tcagcgatat cctgattgac gctttgaacg attccgtcat gcttgcttgt aatgacattg 2909101 gaacctttgt ttttcgtcag gccagccagt tctttttgat gctgcttcag ttcaagctgg 2909161 cttgttttca aatcgaaatt ggtttgatca agttcatctt gaagctggtt tttctcttct 2909221 tttcctgcaa ctttcagctt tttttccgtt tccgttattg atttttgcaa acggttgatt 2909281 tgcagatttg tcatttcaat ttgcaaattg gcttgctcca cttcatcaga atgatcctcg 2909341 ccctcatact caaaaagctt atcgcccttt ttaacctgat cgccttcttt gacgtatgtt 2909401 tttttaatgc tgcctttttc tgaatctatg tatactttct gctgtttctc aggttcaacc 2909461 tttccagaaa acgtttggcc tgattctgaa tctcctccca tgtataccgc gaccgattca 2909521 gcatagggct ccgatgatac ggcaacttgg ttcatgtgag taaaaaagta aaaaccgcca 2909581 gcgccgatcc cagccaatac aagcacaccg gcacatatcg caccgccaat aagccatttt 2909641 ttcttcttgg acacaacgat ctcctctttc tgtaaactat gtaatatttt cgaaacattc 2909701 taaccaatat tatctattaa ttcaaaaaga cttgcaatcc ttttattgaa atgacggaat 2909761 caaatagaaa aattgtattt tcaaagccga ataaaaaaaa tcccggcttc aaaccgggat 2909821 tttttcatac agtaactagc tctttttcat ttttaatcaa gtcatatgtc aagcatacag 2909881 gtttatttgt acggggatca gtcacgattt cggcatcaat ctgaaatacc tgcttcaaaa 2909941 tgtctggtgt catgacctcc agagcagttc cttccttgat gaccgtgcct tttttgagcg 2910001 cgatcatata atgagaaaaa cgagctgcat ggttaagatc atgaatgacc attaaaatcg 2910061 tccgcccttg ctctttgttg agtctgtcaa gcagctgcag aatttcaagc tgatgtgcaa 2910121 gatcaagata cgttgtaggt tcatccagca gaagcagttc cgtcccttgc gcaagcgcca 2910181 tggcaatcca cacacgttga cgctgtccgc ctgacaatgc ctcaatcggc cgttcagcat 2910241 attcagccat gcctgtttct tcaagcgccc atttgataat ccggcggtct tcgtcattta 2910301 atctgccgaa tcctgattga tgcggaaacc tgccgtacga caccaattcg tgcactgtta 2910361 ggccgctcgg cgcttcaggt gtctgtggaa gaatcgccat atcttttgca atgtcctttg 2910421 tagacatttt atgaatcgct ttgccgttta aatagacggc acctgcatgt gaacgcataa 2910481 ttctggacat tgtttttaaa atcgttgatt tcccgcagcc gttcgggcca attaaggtgg 2910541 taattttccc tttaggaatc gatatattta aatcctctac aatcaccctg tcgccataac 2910601 cgattccaag ctgttccgtt gataatgaat tcatattcgg ccccctcctc taattcgctt 2910661 tcatcaataa ataaataaag taaggcgcac ctagcacgga aatgacaagt ccgaccggaa 2910721 tttctgatgg tgccaataca tttctcgcca gcgtatcagc aagcaaaaac aggaatgagc 2910781 cgatgaaggc ggagaccggt atcagcgtct ggtgacgtgg accggtcagc cttctagcca 2910841 catgcggcgc gatcaatccg agaaacgcaa tgccccccgc agctgccacg catgaagcgg 2910901 caagagtgac cgctgccaga agaagaatcc gtctttcctt ttcaacagcg gtgcccagcc 2910961 cggtcgccaa ttggtctccg agctgcataa tgttcaaata gcgtgcctta tataaagtaa 2911021 acagaagcaa gatcacaatc caagggagaa tcgcccagat catattccag ttcgcccccc 2911081 atattgagcc ggatatccaa accgcggctt gcataaaatc atgagggtcc atcttgagct 2911141 gaaaaatcag caacagggcg ttgaatccgg cattcacccc tatgccgact aaaatcagcc 2911201 gaatcggtgt cacgcctttt ttccatgcca gaatataaat gagaaacgca gcgaggattg 2911261 ctcctgccaa agcactgaac ggcagcataa atgttccgaa aaagctaaga tctgaagctg 2911321 acccttgaaa aaagtatata aaaagcacta cagcaagtga accgccggcg ttaattccga 2911381 gaataccagg ctcggcaagt tcattttgag acacgctttg caaaatggct ccagctacgg 2911441 agatccctgc tccaacaagc aaagaaagga tgatccgggg cagcctgaac tcaaataaga 2911501 caagttcatc acgcgccgtt ccttggccga aaaagacctg aagcgtttta agcggtgcaa 2911561 ttttgataac gcccaaattg agactgataa aaaagaccac cacgataagc aaaaaggtca 2911621 cagccattac aatgagcggt ttgtttgttt ttgttttcat tacagccctc tcctttcacg 2911681 acgtgccaaa taaaagaaaa agggaacgcc gataagagaa gtcagcgcgc cgacaggcgt 2911741 ttcaaagggc gcatttacga gtctggccgc tatgtcagca aaaacaagca aaacagcacc 2911801 gagcaccgcc gagcaaggaa tgatccaccg ataatccaca ccgaccaaaa aacgggtaat 2911861 atgcggaatg atcagcccga taaatgcaat ggtgccggca atggaaaccg cagctccggt 2911921 cagaattact acaataagca tgccaaccag tttcaccgct gatgtatatt gtccaagccc 2911981 ttttgccaga tcgtcaccga gacttaacac tgtaacagac cgggcgatga aaaacgcgag 2912041 cgttaaaccg acagcccctg caataagcaa aagctggacc cccgaccatt tcacacccgc 2912101 taccccgcct gcgtaccaaa agctgatatc ctgagcgaca tcaaagcgga ttgcaatggc 2912161 agttgaaatg ccggtaaaga aataagtaac tgccgtaccc gccagagcaa gctttacagg 2912221 cgtaagtccg ccccttgaaa acatgcctat gcccattacc gtcgatgccc ccagccccgc 2912281 tcccgcaaag gaccatagca caagccccat tgcagaaagt ccgggaaaaa aggcaaacgc 2912341 aatcgaaacc gcaaacgcag agcctgatgt cacacccata atcgaaggct ctgccaaagg 2912401 gtttctcgtc atcccctgca tgattgctcc cgacactgcc aacaatgcgc ctacaagcgc 2912461 ggcagccgcc gttctcggaa gccgaagatc atgtataatt tggtgagatg tctttgtcgg 2912521 ctgataatga aaaatggcct cccatacagt gcgcaaatga atatccgctg cacctaggga 2912581 tatggataaa aatgcgccaa ggcaaagcag gcatagacct gcgataagga cgatgaccgc 2912641 gccatatgtc cttgacgtcc attggatttc ttctgatgca gtccgtatat ttttatgttg 2912701 actcaactgc cgtacttcct ttctgttact gataatgatt atcaattgct gtttcagtat 2912761 atcacttttt tcagctgatt taatagagtg ttttgaacaa aaatgaaaat gcatttgcaa 2912821 aaatatcgtg tcaaccggca cttgcagtgg tataatcaca gatgataatg attctctttt 2912881 tcatctatct tttagaaaga aggtatgaga tatgacccat atatacaaga aactcggagc 2912941 cgcgtttttt gccctgttat tgattgcagc gctggcagcc tgcgggaata actcagaaag 2913001 caaaggttct gcctctgatt caaaaggcgc agaaaccttt acatacaagg ctgaaaacgg 2913061 aaatgtaaaa atcccgaagc atcctaaacg ggtggttgtc atggcagacg gctattacgg 2913121 ctacttcaaa acactcggca tcaacgttgt aggtgcgcct gagaatgtat ttaaaaaccc 2913181 ttactacaaa ggaaaaacca acggcgtcga aaacatcgga gacggcactt cggttgaaaa 2913241 ggtcattgat ttgaaccctg acctgattat cgtctggaca acacagggcg ctgatattaa 2913301 aaagcttgaa aaaattgcgc cgactgtcgc agtaaaatac gataagctcg acaacatcga 2913361 acagctgaaa gaatttgcaa aaatgacggg aactgaagat aaagctgaaa aatggctggc 2913421 caagtgggat aaaaaagttg cggccgctaa aacaaaaatc aaaaaagcgg tcggtgacaa 2913481 aaccatttcc attatgcaaa cgaacggaaa agacatttac gtatttggta aagactttgg 2913541 aagaggcgga agcatcattt acaaagacct cggcctgcag gctacaaagc tgacaaaaga 2913601 aaaagccatt gaccaggggc caggttatac aagtatttca ttagagaagc tccctgactt 2913661 cgccggagat tacattttcg cgggcccatg gcaatcaggc ggtgatgatg gcggcgtttt 2913721 tgaaagctcc atttggaaga acctgaatgc cgttaaaaat ggccatgtat acaagatgga 2913781 tccgatcgga ttctatttca cagacccgat ttcattagaa ggacaactgg agtttattac 2913841 ggaaagcttg actaaataaa caaaagagcc gcctgcccgc ggctcttttg cttatttata 2913901 aggaacggct caatttgaat catatcggat attttctttg agccattcat attaagctgc 2913961 atcctcatca cgatcagttt ttttatgctg gagagactga aaaacgtttt ttgcatattt 2914021 aacgaacgga ttcctaacag gagaaattgt gattttataa aaaagacacc tgagcaaatc 2914081 aggtgtcttt tcattatgct tgtttttctt tctggaactt gttactcaca aatggataaa 2914141 cgattaagcc gacaaagaat aaaccgatgc cgagtataaa tgtcgttaaa tctgctgtgc 2914201 ctgttacgat aacaaacacg gagtatgcac acgccagtat cgcgatcaat ccgtctctta 2914261 cacgggagcc tttcagctgg tcatacgttt cacctttgat gactaccttc aagctgtaga 2914321 ttgcagatac cagatacgga attaaatatg cgagtgtagc cgctgtcgtt aaaaatgtaa 2914381 atgcgtcact tattgtccgg gaaataaccg agaaaatgaa gacctgtgac atgacgtttg 2914441 taataatgag tgcaatgacc ggacttccct ttttattcgt ttttgcaaaa aatgccggga 2914501 aatctcctgc tttagcggct tggtatggca cctcagagcc aagcaaaatc cagccgagca 2914561 tcgttccgaa taaacaaagg atagccaaaa gcgccataat cacgcttccc gcgtttccaa 2914621 caatcgcata gagtacatca acaaatggtt tttcagagcc gacaagctta tcatgcggca 2914681 gaacacccat cgtaattaaa gtcacaataa tatatatgct caaggcaatc agcaagccgg 2914741 taattgtcgc acgtttcaca tcacgctgag agcgcgcacg gccggacagg atcaccgcgg 2914801 attcaattcc gacaaacgcc cacagtgtag aaatcgcagc gttatgaacc tggccaccaa 2914861 ttccaatgct tgtgccgttt tctccttgaa ccgggaaata aaaatgaccg aataatgacg 2914921 tttgaaacac aaacaaaccg gcaacgataa agaagacaaa acctaatact ttagaaagcg 2914981 ttgtgacaaa gtttaattta cttgcgccgt taatgctggc aacaagaatc gcgtgcgttc 2915041 cccataacaa gatcgtacat acggcaaacg tcagtaattg gccgagtgtc acctcttgcc 2915101 cgccgatcga aaacatctca cgtttatcaa ccaagatcgg gaagaacgaa gtcaagtaac 2915161 cggcgagact tgtgatgatc gccacgttac tgatccagct cgccacccag tagccccaca 2915221 ccattgtgaa accggcagcg ttgccttttt tcgggtcaga aaacagcgct cttgcataac 2915281 tttgcggtcc cgctgtcagt tcaggcttgc gaatggacaa gtgtccgaac acaagtgcaa 2915341 tcatcagcac gccggcacct gtcaaaagcc aggcggacgt agctccaaac ggactcgcaa 2915401 ttgaagcaag cgagctcggc aaggagaaaa ttcctgatcc aaccatattt ccaacgacaa 2915461 acgccgttaa taaccaaaaa ccccattttt ttgtctgttc cattccagta cctccatgat 2915521 tctttgtacg gaccagaccc cgagatcata taaacgcaaa aaaagcctga acaaaagtcc 2915581 atgcttaaag aaacacacac ccttgatctc cggatagccc tccgcgaaaa agcacgcggc 2915641 agtcctgcac ttattcagat acagtcccag catagagaag gatcggcttt ctccacactt 2915701 cggcgctgat gccttttaca catgtttaac agcccctgtc agcctagcat gtgtgactca 2915761 tcatccgcgc aacctctacc tcactgagaa agagtgagga tttaattatt cagttactcc 2915821 cagaaggtta tcaaagaaag gatgatctgt caaagggaac agatggaaaa tacggataga 2915881 gccaagccct atccgcatgt ggttatcgat tatttttctt tttttgcaca gcttcttgaa 2915941 gcggatcatc ttttagagct gaaccagcat cttcaagagc tccttggatt acgttttttt 2916001 ctttttcgga acgttttcct ttatctttat taaagaaacc cattcgtatc acctctttta 2916061 aaaaataggt acatgtttaa gatgcctttt tcctgaaaaa ttatgcggga tattttttat 2916121 cgtccaaagt cctgttgatc aaacatacat tctcttgata tatttgtaat tcagagattt 2916181 tttgcaaaag ataaaaggag aagcggcaaa tgacaggaaa aacacacatc atgggaggca 2916241 tcgcttcttg tacggcagcg gcttattatt atggatttga tccagtgctt atggctgcgt 2916301 caggcgcggt tggagcatta atacccgata tctgccacac acaaagcaaa atcgggagaa 2916361 aatttcctat tttatcgaaa gtggtcagct ccgtttttgg ccatcgcacc tttacacaca 2916421 gcctgctgtt tatgctcatc atgtttttta tcacttctac atacattcca gataaaaaca 2916481 tatcagccgg cctgatgatc ggaatggcga gccacttgat tcttgacgct tggacggtga 2916541 acggaatcaa attattattc ccttccacga tccgcgttcg gcttccatta tatatgaaga 2916601 caggcagttt ttctgagcag ctcgtgctag ccggcctgac ccttgcttca tgttactact 2916661 tttatatgct gtttcatggc cgcatgtttt aaacatgagt gctgagactt gtctgaaccg 2916721 gctgttttta gtaggtttta cttaagaagc atttcatgca gatgatcaag aaaacgtgag 2916781 gagtcatatt gatgaaagga accttttttc acaatcagcg gtttttatgt ttttcgatct 2916841 tatttatgtg gatcaaaacg tatgtgatat ataaactcgg ctttgatttg caaatcgata 2916901 ctctgttgga ggagctaatg ctgctggtca acccgctcag ctttattctt cctttattcg 2916961 ggatcggcct gtttctaaaa gaaaacaagc agcgggcctt tttgctgatt gccaatttgg 2917021 ttctgactgt tatcttgatc tctaatacga ttttttacgg cttttatatc gattttatta 2917081 ccatcccggt tttatttcag gccagcaaca tgagcgatat gggcagcagt gtaaaagaac 2917141 tgttccatcc tctgtttatc gccctgtttg tggatttggt ttttctgctg ttgttcgcca 2917201 gaaaaaccaa acacccacag acaaaagccg ctccccacac gatcaaacgg tactatgcag 2917261 cttcctgcgg aatgctttta tgcacactgg cacttgcaga agtacagcag ccgaagcttt 2917321 tggcacattc ttttgaccgg gaaatgctag tcaaaagcat cggcctgttt cagttccata 2917381 tttacgatac aatttctcag actgttaata tcagcgcgaa agcttttgcc gatgaagaca 2917441 gtataactgc cattaaaaac tacacagagg ctgattacag caagcctgat caaagcaaat 2917501 tcggtcttgc aaaggggcgc aatgtcatct ttgtaacact tgagtcgacc caaagctttg 2917561 ttctgaatga aaaagtaaat ggaaaagaaa ttaccccatt tatgaatgat ctcataaaaa 2917621 aaagctattc ctttgatcat ttctatcagc aaacagaaca aggcaaaaca tcagattcag 2917681 aatttatcgt cgctaactca ctgtatccct cccttagcgg cgccgtcttt ttcacgaaaa 2917741 gcgaccatca atttcatacg atgtataaat cgctgaagca gcacgattat tattcagccg 2917801 tctttcacgc taaccataaa acattttgga acagagatgt catgtacgat acatttggca 2917861 ttgaccgctt ttttgatgtt gatgattttc atgtcactcc cgggacatcg acaagctggg 2917921 gcttaaaaga caaagaattt ttagagcagt ccgccaaaaa gctgaaaagc ctaccgcagc 2917981 cgttctacag cagttttatc acgttaacga atcattttcc gtttgagatt gatgaaaagg 2918041 atcagctgat agatgaattc gattcaagca gtgatctgtt aaaccgctat gtgaccacgg 2918101 ttcgctatga ggatgaagca ttgaagcatt ttatcaaaaa actgaaggac gaaggcttat 2918161 acgaaaattc gatgatcgta tttatgggag atcattacgg catttctgaa gcccataacg 2918221 aggcaatggc tgagttttta gggaaagacg aaatcacacc gtatgacaac gttcagctcc 2918281 agcgggtgcc gtttatcata catatcccgg gaatcaccga tcaacagccg gaaaccatcc 2918341 ctgatgccgg gggacaggtc gacgtcaggc cgacgctgat gcatttgctc ggcgttgaga 2918401 caaaaggcga tatccaattc ggcaatgatt tgctgtcggg cgaccgcacc ccattcgccg 2918461 ttctgcgaaa cggcagcttt attacgaacg attatgtata cacaaagaac acgtgctata 2918521 gccaaaaaac aggtgaagtg ctggaagatc aggatgcgtg cctcccttac aaggagaaag 2918581 caaacgaaga actgtctctc tctgataaaa ttttaaatgg tgacctgctc aggttttccg 2918641 aatgaaaaaa tccctctatc aagagggatt ttttacgttt ccaatatcac cttgccagtc 2918701 agcttcgttt catagccgtt taaatgagac agattcgcct tgtagtcctc agaattcaaa 2918761 atctccttca cggctttgag caactgctca ttttttttca aaacaacgat atcatattgt 2918821 tcgtcgatga gcgggataaa atcaacactg cccatatgtg ccgcgtgctg tgccccgatt 2918881 cccgcgtcag cctgtccgct tgaaacttgt gaagcggcag cgtaatgatc agtcacgata 2918941 tcgccatatc ccactacatc agccggattc acaccaagca agccaagctg ttcatcaagg 2919001 agcacccttg cgccagaacc cttttccctg ttgatgatcc ggatatcggc tcttttcaag 2919061 tctttccagc cttgaatgtt tttcggattc cctttttgca catacagtcc tgctttgcgg 2919121 agaacgacat tgatgagaca aaacggttca cctgtcaaaa tccgttttac ataaggcgcg 2919181 ttatactggc ccgtttctgc atcgtacaaa tggaggctga caatgtcaca cttgccttga 2919241 tacatatcaa tcaggctgtt taagcttcct ttgtatttac ggagcggcgt ctcctgaatg 2919301 gcattctcca aatgcttgct gaggatatcc atcgaaatgt cctgtccgct gatcatgaca 2919361 tttggtctgc cgtccggctc agcctcctgc acctgtttcg gcgcttcttt tgcagcgatg 2919421 ggctgagaca ttctcatatt cgttttatat tgctttaaat cttcttcatc cacacgcatc 2919481 tgccttccga cacggtaagc aggcagcacg ccttttttaa tcaagtcata aacggtcagc 2919541 tttgatacct tcagcagacc tgcaacttct tctatcgtat aggaagaggt ttcattcatc 2919601 atcatcactc tcctatttta ttataccttt tcgccgaatg taaaaaaacc cacataaacc 2919661 aaacataatc agttataatt agttatatct aatgataagg ggtgcaatca tgtttaagaa 2919721 gtattctatt ttcatcgcag ccttaactgc ttttctgctt gtagcaggct gttcttcaaa 2919781 ccagtcttca acggacagcg agaaaaaagt aacgttaacc atctcagctg ccgccagcgc 2919841 gcaggatgca cttgaggaaa tccaaaaaaa ttatgaaaaa gatcatcaac atataaccat 2919901 ccaagataac tatggctcat ccggcgcctt gcaaaaacag atttctcaag gagcaggagc 2919961 agatctgttc ttctcagctg ctgaggataa atttaaaaag ctggtggatg atggagatat 2920021 cgcaaaaaaa gacagcactg aattagtcgg taatgaaatt gtgctggtcg taccgaaaaa 2920081 cggagattca cctgtgacaa gcttcagcaa tctggctgaa tcagaaaaaa tcgctcttgg 2920141 cactccggaa tccgtaccgg caggagctta tgggaaagaa tcactgacaa agctgtcttt 2920201 atgggacaaa gtgaaggata aaattgtgta tggaaaagac gttcgccaag ttctttctta 2920261 tgttgaaacc ggcaatgtag acgcaggtgt tgtttataaa acagatgccc tagtctcgaa 2920321 aaaggtcaac attgttgacg aggcaaaagc agatacacac agcccaattg tctatccgtt 2920381 aggaatcgta aaagatacaa aacaccgtaa ggaagcgaag gaattttacg aatacctgca 2920441 atctgatgaa gcaatgaaag tatttgagaa atatggcttt actgccgagt agcataagcg 2920501 cttcagaatt tttcacaccc gttgtgcttt cctttcaggt ggcggcagtt gccggaattg 2920561 ttgtcattat tctcggaaca cttgctggag catggatgtc acgggcatca tttttcggaa 2920621 aaacggcact cgaaacatgt tttatgcttc cgctcgttct tccgcctact gttgtcggtt 2920681 ttattctgat cgtcattttc ggaaagcaca gcttcatcgg acaagccatc gagtggattt 2920741 tccagcagcc tgtcattttc acctggtggg ccgctgtgat cgcctcggct gttgtagcct 2920801 ttccgcttat gtatcaatca gccaaaaccg gatttgctga cattgatccc gatatacaag 2920861 gtgcggcaat ggtagacggc gctagcagat ggaaagtgtt tatccatatc tccgtcccgc 2920921 ttgcctatcc ttcgttactg accggaagca tccttagcct tgcgcgggcg ctcggagaat 2920981 ttggcgcaac actcatgttt gcaggaaaca tccccggtgt tacgcaaaca ctgccgacgg 2921041 cgatatatgt cgcattggat tccggcaaca atacccttgc ttgggcgtgg gtcgtctgta 2921101 ttgttgtcat ttcctttttg atgctgtttt tcattcaaca gaaaaaaacg cactaaaaaa 2921161 actccccata acggggagtt ttttgattaa aacagaagct catcaggatt tggaccgaca 2921221 cgctcatctt tatttaatgc gtcaattttg tccatgtctt cttgagacaa ttcgaaatca 2921281 aaaatatcag cgttttcgat gatacggtgt tctttaatgg attttggaat ggttacaact 2921341 ccatgctgca gatcccagcg caaaatcact tgagccacag atttattgtg tttttcagca 2921401 atctgtgtca gtacttcgtt atccaaaagc tgtccctgca tgagcggaga ccacgcttcc 2921461 agctgaatgc cttgcccttt gcagtaatct cttaattctt tttgcgtcaa gcgagggtga 2921521 aattcaactt ggttcaccat cggtttgatt tcagcatctt tcaacagctc ttctaaatga 2921581 tgaacttgga aattgctgac gccgatcgcg cgaattttgc cgtctttgta cagcttttca 2921641 agcgcgcgcc atgtatcttt atatttatct ttgccaggcc aatggatcaa atataaatct 2921701 aagtaatcaa gctgcagtct ttctaggctt ttttcaaagg cagcaagcgt tgtttcatag 2921761 ccttgatctt cattccacac ttttgatgtg atgaagagct cttctcttgc cacaccggat 2921821 tctttaatcc cgatgccaac gccttcttca tttttgtaga tcgctgctgt atcaatactg 2921881 cgatagccat ttttaattgc cgctttcact gattcagtcg cttcattacc attttctact 2921941 ttaaaaacgc ccagaccgaa ccaaggcatt tcaactccgt tatgtaactt tacagtatct 2922001 tttaaacttg ttggcacttg aacctccacc ctttcactga aatgtaagcg tctatattat 2922061 ctcacattcc tctcagccga taccaataat acgcttaaga ccctcttttt gcttcttttt 2922121 tcacagcaca ggcaaatcca aacactattt ttttcctatt ttaacaatat tgagattaca 2922181 aatacattga gcagggtatg cgtgtagtgt aaccaaatga aaacaaagga ggaaacaact 2922241 tgaaacgtat tcgtatccca atgacacttg ctcttggtgc cgctttgaca attgcccctt 2922301 tgtcctttgc ttccgctgaa gaaaatcctg ctccgaagat gtcgcagaca actactgctg 2922361 gaacaactgc cgctgatgta ggtttaaacg tcaacctgga tgtacttgga attgccaacc 2922421 agatcgctga tgccatcaaa tccgcacaga atagggatgg ctttgtgaaa aacctcatgg 2922481 agtcttcctt ctacgcgtcc ggccaaaaat ataacgtcat ggtctttaat ttaagccagg 2922541 aatatgaaga tcatttgaac ggtgtgcaat tttacggctc agccgtttac gacggcatta 2922601 cgtatggcat ttgggtattt gaagatggaa cctttacaaa caaaggcgat ggcggctgga 2922661 tcaactgggc cttcagaggc tggttcgacc gggatggcag cactgtcgca tttcatcgcc 2922721 cttaatataa aaaaagctgg cgctctaacg ccagcttttt ttctgcattt attcgccgcc 2922781 ttcaagcatg gcggcttcga catcattaat gtattggcga agctcatggg agatgtcccg 2922841 ggaaatttcc ctctcttcga agagcgtttg aatttcattt ctgatcgcct gcacagcctt 2922901 cagcttcact tccagcttct gattttcaaa atgggcactt gattttaact catgatggct 2922961 gtgctccagc ctgaaaatta actgcttata gaatgtaatg acagataaaa acacttcttt 2923021 atgctcatcc gtcttatgtt tttccagata ttctatcgct gcttttgccg ttttcactct 2923081 tgttgcccgt atcaatcccg cttcatttaa aatcgacatc tccggctttt tatgttcacc 2923141 gaagaaaatc caatacatca gcctcttgag ccttgttttt gataacccga ctttaaacgg 2923201 gttggcatac aaaatttcca actcgttaaa tcgttcttgc agcacatttg ctgtttcttc 2923261 cgggatgtct ccccgctcca gcattttcat cagcgcctct tgctcagcct taaccccctg 2923321 cgcacggact tttcgctcgt gcttcttaat gcgattagat gatgtatact gctgaaaacg 2923381 aagatttttc attttctcat tgtattcagc tatcaccgca agagaggccg ttttgtttgt 2923441 ctcattcatg tcctctttaa tcgtttgaag ggctgttttg atcaacttgc gtctcgccgt 2923501 cagcagcttc ttatttcgtt cctcgtcctc ttcttctttt tcagtcagaa ttggcagcac 2923561 aacggtggca atgacaagcg tgcataaaat gacgccggct gctaaaaaga gaatcagatt 2923621 tctttccgga aacggcgtac cgtcctccag gaaatacgga atggaaaaag aacctgcaag 2923681 cgttactgct ccacgcacac cggaaatcga aattaacagc gtcgaacgaa gacccggttt 2923741 atagatgttc tgatctttat taaagaacca tttgccgttc cagaagaaca gcacccacag 2923801 gaatctaagg agcattaatg taaatgtgat gactaggata tagccgatca ccttcatgtt 2923861 gctgatggca gtgtcgttaa agataacaga aataacatca gggatttgcg tgccgagaat 2923921 aacgaagacc aggccgttca aaataaataa aataatgttc cacgtacttg aggagacgat 2923981 ttgcagcttg atcatcgttg attccagacg atcctgttca accgcatggg taataccgcc 2924041 agctacaaca gctaaaatgc ccgaaacgcc gatttcttca gctgccaaat aaatcacaaa 2924101 cggcgtcaga atttgaatca gcatatgcat cgtgacatcc tgcatgccaa ggcggcgcag 2924161 aaataggcga aaacgaataa tcaaaaatga aatgacaacc ccgcacagca agcctccgag 2924221 agaaataaag acaaagctga cagccgcttg tgctaatgaa aatgcaccag tcactgccgc 2924281 tgcaatcgca aacttaaagg ccaccagacc tgatgcatca ttcatcagcc cctcaccttc 2924341 cagcaggcga agaatccctt ttggcatttt cactcttcct gataatgcgc tgacagcgac 2924401 gacatcagtc ggtgaaagaa tggccgcaag tccaaaggcc gctgccagcg gaatagcagg 2924461 aatcatccag tgaatcgtgt agccgcctac aatcacagtc gcaaatacaa ggccgagtgc 2924521 aagcaataaa atcggagccc ttaaattcca aagctctgcc cgcggtgtcc tctttccatc 2924581 attaaatagc agaggcgcga taaaaagaac aaaaaacaat tcggtgttta attcaaaatg 2924641 aagtccctgt ggaaatgagg cggcaagaat cccaagagcc acttgaatca gcggcaccgg 2924701 aataaacgga ataaaccggt tcacgatatt agaaatcgca ataatcgtta ataatacgag 2924761 cacaactaaa aatatgtcca aatgcatgac ctccttcgtc tgttgtgtgt cggcatgatg 2924821 agccaaaaaa tctgtttgtc taaaagccct tgagctaggg tggccttgca tccgctatgt 2924881 ggtttcgcag gagttctctc cacacttgtc ttcttttata gtaccctttt tagggtattt 2924941 tttctcatga tatgctcaca gtgaactttt ttgcagaaga gcaaattata gaaaaaagag 2925001 acaggaagct actccctgtc tctcgtcttt ctttctcaat catgaaaatt cgtaccgtca 2925061 gttgttgctt taataatgcc cgcgcgaatg acaaagtcac cgaaatgctc gccttcctcg 2925121 cgttctttcg catagcggga aagaaggatg cgcagctcgc ttaaaatgtc tgcttcaccg 2925181 atgttttcac ggtacatttt gcttaaacgg cttccgtcaa acgcagcgcc aagatacata 2925241 ttatatttgc ccggcgcctt tccgataaat ccgatctcac cgagtgcatg acgtgcacag 2925301 ccgttcgggc atcctgtcat gcgaatggtg atttcctgat cacgaaggcc gttttcgtca 2925361 ataatctctt caatcttatc taacagggtc ggcaaataac gttctgcttc agccattgcc 2925421 aatccgcagg tcggaagagc gacgcacgcc atcgagctgc ggcgaagcgc tgaatagtgc 2925481 ttgccgtcag ttagtccgta ctgttcaatt aaagcactga tttcttcttt tttatcgctt 2925541 gaaacgttcg caatcattaa gttctgattg gctgtcagcc ggaactcacc tgtatgaact 2925601 ttggcgattt cccgcaagcc agtcatcagc ttataatcat cgtaatccgt tatacggccg 2925661 ccttcgacaa acagcgtgaa atgccattta tcctcgatgc cttccaccca gccatagcgg 2925721 tcgccgttat gatcgaaatg atacggcttc gcttcttcca ggctccagcc gagacggttt 2925781 tccaattctt cttttacgtt ttctaaaccg aggcggtcaa ctgtgtattt gaaccgcgca 2925841 tttttacgga cagaacggtt gccgtaatca cgctgaatcg taatcgtttt ttcagcaacg 2925901 tcatacattt gctcaggccg gcagaaaccg atcaccttgg ctaattgcgg atatgtcgca 2925961 gtatcgccat gcgtcattcc cataccgccg ccgattgcca cgttaaaacc gatcagcttg 2926021 ccatcctcga caatcgcaat gaatccgaga tcttgtgaaa agacgtcaat atcattagac 2926081 ggcggaacgg caataccgat tttaaacttc cgcggcagat agagcggtcc gtacattggc 2926141 tcgacttctt cctccggcgt gccggcaact ctttcctcat caagccaaat ttcatgatat 2926201 gctctcgtcc gcggcagcag atcatcactt aattttttag accactcgta tacctctgag 2926261 tggatttcag attgataagg gtttgatgca cacatgacgt tacggtttac gtctccgcag 2926321 gctgcgatcg tatccaaaag tgctgagtgg atcgtctgaa tggttttctt catgttccat 2926381 ttcagaattc cgtgcatttg gaatgtttca cgtgtcgtca attttaatgt gccgttcccg 2926441 tatttctggg acaggtcatc catgacaagc cattgttcag gcgtcgagac gccccctggc 2926501 atacgcacgc gcagcatgaa ctgatatgcg ggctcaagct tctgcttttg gcgttcattt 2926561 cggaggtcgc ggtcatcctg caaataactg ccgtggtgtt tcatcaggcg gttatcatca 2926621 tccggaattc ccgcactgat tcgatcgagc atcacttctt tcagcgtgcc gcgcaaataa 2926681 tcactttctt ttttaatgcg ttcaacatca cttggagagc cgtccggtgc ttttagaatt 2926741 ttggtcacca tgttgaaaaa ctcctttcaa gtcaaatcaa tatacatcac gctgatagcg 2926801 tttttgctgc tgcatatcgg caagataagc ctccgcctct tcgcggctca tattgccttc 2926861 tttttcgata atttcaagca atgtgttatg gacgtcatgc gccatgtgct tttcatctcc 2926921 gcaaatgtaa acagccgctc cttcttgaag ccattcaaac aattctgcgc tatgttcaag 2926981 catgcggtgc tgcacatata ctttttcttc cgtatcacgt gagaacgcca catccatttt 2927041 tgtcagcaca ccgtctttga gccaattctg ccactctgtc tggtaaagga aatccgtgac 2927101 aaagtgctga tcgccaaaga acatccatgc ctttccttcc gctcccgtct cctcacgctc 2927161 ctgcataaac gaacggaaag gtgcgacgcc tgtcccaggg cccaccatga taatcggtgt 2927221 ttcagggtct ttcggaagct taaagttttg attgtgctgt acataaaccg gcagtgtgtc 2927281 tcccggctgc agtcgttccg cgcacaaaat cgagcagacg ccttttcgtt cacggccgtg 2927341 cgcatcgtag cggactgcgc cgattgttaa gtgcacttca tccggatttg cggataaact 2927401 gcttgcaatc gaataaaggc gggcaggcat ttttcgcaaa atcgagacaa actcctgcgc 2927461 agatacacta aatgggccat agtcacggac gagatcaagc aaatcgcgcc cttcaatata 2927521 ggcttttaca ttctcctcat ttcccggggc taaaagctct ctaagctcat cgttccctgt 2927581 cagctgggct gcctgttcaa gaagcggttt tgtgagaacg gtaatctcat agtgagaaat 2927641 cagcgcttct ttcagcggtc ggacatcacc ttgcttatta agcgtcacaa tttcttccgg 2927701 gtcccaattc atttccttaa ggagcagctc gacaagttcc ggatcgtttt ccggatagac 2927761 gccgaggctg tcaccaggct cgtaagtcag gccagatcct tcaagagaca gctccacatg 2927821 gcgtgtttct ttatttgatc ctctgccgtt taaatttaaa ttttctaaca cttcagcccg 2927881 aaacgggttt gttctggaat acgaagactc accggtttgt gacgcagccg ccggcgcagg 2927941 cgcggcgctt ccgcccccag cttcatttaa tcctttcaat acaccctcaa gccattcggc 2928001 tgccggttca tcatagtcaa gatcgcaatc aacgcgcgga gaaatccgtt ttccgccgag 2928061 ttcttctaag cgttgatcaa attctttccc tgtctggcag aaaaattcgt acgaactgtc 2928121 accaagcgcc aaaacggaaa agcgcaggtc ttcaagctta ggcgcccgtc ttccgtgcag 2928181 aaattcatga aacgacagcg cgttatcagg cggctcgcct tctccatgcg tactgacgac 2928241 gattaaaaga ttggttacct tcttcagctg attcggctta aaatcgctca tggatgagac 2928301 ggtcacttga aaaccgctct gttcaagctg cttgccggca ttttctgcaa gcccctgtgc 2928361 gtttcccgtc tgtgaaccat aaagaacggt cacttctttt gaaacggccg gtgccggtgc 2928421 ttccgctgac acagctgccg ccggcgtacc cgcagcttct tgggcggaaa cagattgagc 2928481 ggataaatat ccgctcagcc agattttctg ggattcggtc aaggtcggca gaaggcggtt 2928541 aaggagctct gcctgctcct gattaaacgg actgttcatt acctgaagtt gcaacgtatc 2928601 cacctcacaa agttataaac tgatcgaaaa ttgcatctaa ttgaacttta ccggaatact 2928661 aggcttaagt aaaatatatt tacatgatga taactattaa gaatcctaat gataaaacgg 2928721 ctatgcttca tgtaaataga aaaaagagaa ggactccctt ctcttcattc agcaatctga 2928781 tataagtgag gcggcacagc ggttacaaac ggactggctt cacctgtata aaataccgcc 2928841 agcatgtgca tcgcacgggt gcacgcagta tataaaagcc tgcggtcgtg ctctgtatga 2928901 tagtgttctt cagatgcatc atagacaagc actgcgtcaa attcaattcc cttcgctaaa 2928961 tacaccggaa tcacgcaaac acccttttga aatggttgat tttctttatg aatcaggcga 2929021 acatctgtat attcactcat gtgggcgtgc gcctgtatgc attgatgcgc agtcttgcag 2929081 atgacggcta ttgtttcgtg cccttttttc ttgagccggc caatttcttg cgcgagcttt 2929141 tggcaaaggc tctcatgtcc ttcagttttg acaacgagcg gcatttcccc gcttctatta 2929201 aacggctcaa tatccgctcc atcttgaagc atcgctttgg taaactcgac aatctgcctt 2929261 gttgatctgt atgttctctt taaacgaaca tactcagcag gctcatcctc aaagcacgca 2929321 tccatacgct gatccccgtt tatggtatgc gcgtagatgg actgattgat atcaccgagc 2929381 actgtcatgc tggcagccgg aaaaatgctt ctcatgtaag ccatctgaaa cggtgaatag 2929441 tcctgggctt cgtcaataaa tagatgtttg attttcgtat ttttctttct gccctcaatc 2929501 agatcctgca tataaagaaa cggtgccgcg tcctcataga gcaatttatt atccgtaaat 2929561 gccgaacggg tcagctcacc tatcgcatcc atcttctcat gttgaaattt tcctccccag 2929621 ccagaaaaca attgcaaata aagttgtgta acatcaagaa atgcaaggag cctgactgcc 2929681 tgtttgagcg gtttgaaagc ttttttcaca atgatggcgg caagcagctg ctgctctctt 2929741 tgataatcgt taaacgtact ctcgctgaac cgtttccttt cctgcagttt tttgtacacg 2929801 tccaagtagt cctctttgtc aagcagctca gcttcatgaa caacccaatc ctttcgccgt 2929861 tcctttttct caagcttgtt aagctcactc agcagccact tcgcggtttg ctccatccga 2929921 ttcggaatgg agtgattttg atccaatgag taaaaatagg attgaatttg ctcctttgtg 2929981 atcagctttt gtccgcggaa tataatattt ttaaaaatca tcccttcaga ggaaagccgt 2930041 gtgacgtatt cattaatgaa ttgctgaaag gataaacccg ccttccatgt gattcctgca 2930101 agccttgttg gaaaatcgcc tccctttgtt tcggtcaggc aatattcgag ctgatcaaag 2930161 gggctttcac atttgaactt gcggccaaga cgatgctcga tatattcctg aaacgtcgcc 2930221 tgctccatat tctcttctcc taactccggc aaaacagagg agacatagct gttaaataag 2930281 aagttgggtg aaaacaaaac gatttgtccg gcatcaatga caccgcggtg cctgtataac 2930341 aaataagcga cacgctgaag cgcagccgat gttttcccgc tgccagccgc tccctgcacg 2930401 atcaggatct tgcttttttc attacggata atctgatttt gttctttctg aatcgtagac 2930461 acgatgtttt tcatttgggt atcagagtga tggcttaata cctcttgcag catttcatcg 2930521 ccaatcgtca tatcggtatt aaacatcgcc ttgagagtgc cgtttttgat cataaactgg 2930581 cgtttcagca ccatttcccc ttctatcgtt tcaccgggca cctcgtactc cgcttttcct 2930641 ggggaataat tgtagtacaa acttgatatc ggcgccctcc agtcatagat cagaaagtgt 2930701 tcctccttct catccaaaca ggaagctaaa ccgatataaa ttcgctctgc ctgctcctcg 2930761 ccgttttcaa taaaatcaat ccggccgaaa taaggcgatt ttttcaattg atgaattcgt 2930821 ttgagctgct gatccatgcg ccgatgattg tgttcccgat cagacagcag ctctgcctgc 2930881 tgcttaatgc tagccatcgt ttcaatcgct tcatgggcat catcaaaatt aaccttaaca 2930941 tcctcccaaa agctttttct taatccgatg atatcatgct tcaacccgcc cgcagacgtt 2931001 tccagaaacc gctctttttt ttcgagctcc ttcagcacct catctattct cgactgctct 2931061 tccttccatt ccttatcctg ctgattcatg aacggcacct ccagaaaata gttgacaaac 2931121 atagatgaaa tactgtaaaa tataattgga tacatatatt aaatatatga tgcaaactgg 2931181 caaatacaat ttataatagc acattcaccc aataccaatc aaggtttggg ttatttatat 2931241 tatgcagaaa aaaaccgatt tcacttcgaa atcggttttt ttgctattaa ttatctaagc 2931301 gaaaagaacg gtttggcagc ttccaattaa acatatagga acaaacccgg caaacaacga 2931361 gcacgaaaaa cagaacgtat aagccgaacg agttccccag ccagcccaag ccgacgatta 2931421 aaccgccgag cgccgcccat accgcataga tttccgcttt cagcacaagc ggtttgcgcc 2931481 cggcaagaag gtcgcggatg atcccgcccc cgcttcccgt cagcaccgca gccacgatca 2931541 cggcactaag cggatggccc attttgacgg catacagtgc gccttggata gcaaaggcag 2931601 cgaggccgat cgcatctgat aaattgcccc acttattcca atgcttcagc agcagcttcg 2931661 gaaacagaaa cacaattgta atagataaaa gcgcgatttg aaagtacgct ccctgctccc 2931721 atagcgctga caccggaaca ccgatcagca aattgcggat cgctcctcct ccaaaagctg 2931781 tgacaatccc taatatataa actcctaaaa tatcatattc ctcttccatc gcaacaattg 2931841 cgccgctgac tgcaaacgca atgatgccaa tcacactaag cagctcccaa gccattctga 2931901 tgactccctt ttatgtttgt taaattttct gacgacctct agattttata atcgctccag 2931961 cgtaaaatca ataacatttt catgagaaaa aaagataaat ttagagggaa tacggctatt 2932021 gctgatggac atgagtttgc gaaattaaaa aagcgcccgg catacgcggg cgcttttttt 2932081 gttattcaga tttttcgcct ttcagcaggc acataaaaat gataatcagg ataaaagcaa 2932141 tcagggccag gaatggaatc gtaataaaac caaaccagtt aatatattgg cccgagcacg 2932201 gcacgccgct gacacatggc ttaatgccgc taaagccggg cactttttgc tctaagtaat 2932261 gcatgatcga aatgaatgcc ccaataatcg ccatcgggag cacatatttt ttcactcgtg 2932321 tgtccccttg aaaggtggcg atgcctaaaa tcaggacgag cggatacatg aggatacgct 2932381 ggtaccagca cagttcacat ggaataaact ttctgatttc actgaaatac aggctgccca 2932441 gcatagcgat aagagccaca acccaggaag catataaaaa tacgattcta tttttcatat 2932501 tgttacttcc ctttcagctc tttttctatt gtctctttga tttcatcata atccgcaaaa 2932561 tttttgatca ctttatcatt gacgtaaatc gtcggtgttg cctgtatgtt cattttttga 2932621 ttaaggtcag aatccttttc cacttgagaa gcgaatgttt ccttatcaag attttccttg 2932681 agcgtctcag gttttatctt tgtggtgctt tttgcaagat caccaaggag gcctggggtt 2932741 acccattcct gttccgtatc cggctgtttt tcgaacagct tttcatggaa atcccagaaa 2932801 gagtcagggt cttccttcca tacttcttca gatgcaagag ccgctaacct tgaacctttt 2932861 ccatggaaca tgacgttcac gaaagaaaat ttcacatcgc ccttatcaat aaagtctttt 2932921 tgtatttttg gaaagatgtc actgttaaac accttgcaag acggacattt gtaatctccg 2932981 aattctacta cagttaccgg tgcatcgtcc ttgccaagca caggctgccc tttgatagac 2933041 ggctgtccgg acaccgcatc attgccttgt tccgttttgt tattaatgat gacaatggct 2933101 gctagcaata caacaaccac aaccgtaagg atgaccgcga atttcgcaga agactgctgt 2933161 ttctttttca ctccgacacc tcatcgtttt aaaattaaaa aagaagcgga tcgcaattga 2933221 cccacttctt tattttaaca agacaagcgc tgataagaaa accccgaaaa aatgaattct 2933281 ctccgacaat ttatttgttt ttgagacgca tgacgcgcat ggcgttcgcc acagcaagca 2933341 gtgtaacgcc gacatctgag aaaaccgctt cccacatggt cgcaattcca aatgcaccaa 2933401 gaatgagaaa gatcgctttc acacctaaag caaagccgat gttttgccac acgattcgcc 2933461 gtgtccgttt cgcaatccga atcgcttctg ctatttttga cggctgatct gtcatcagca 2933521 cgatgtctgc ggcttctacc gcggcgtctg agccaaggcc tcccatcgca acccctatat 2933581 ctgcgcgtgc aagcaccggc gtatcattga tgccgtcacc gacaaaaatg agtttttcac 2933641 taggcaaaag cttagcttct aatgcttcga cctgcgcgac tttatcttgc ggcagcagct 2933701 ctgcatatac ctcaccaatc ccaagctgtt ttccgacggc ttctcccgtt tgtttcgaat 2933761 cacccgtcag catagctgtc tgtttgatcc caagcgactt cagatcagca accgcctgtg 2933821 ctgcgtcttc ctttatctca tccgctatga tgattgctcc ggcatagcgt tgatctacag 2933881 caacgtgtac gattgttcca gcattttcat ccgggacatc ctcaatttgt tctctttcca 2933941 tgagcttttt attcccagca aggatctcag ttccatttac ctttgcaaaa atgccgtgac 2934001 cggagatttc ttcgtatgac tcaatctcat cggaggaaag cattttcccg taagctttac 2934061 gcacagattc agcaatcgga tgctgtgaat gaagctcagc gtatgccgcc gcttcaagta 2934121 atctatcctt tgtaaaacct tccgcgggtt tgatttctgt cacttcaaag ctgccttttg 2934181 ttagtgttcc cgttttatca aacaccgcgt atttgacttg attcaaagct tctaaataat 2934241 tgcttccctt tacaagcact ccggcctttg aggccgctcc gattccaccg aagaaaccga 2934301 gcggaataga gacaacaagc gcacaaggac aagaaatcac taaaaagata agcgcgcggt 2934361 acacccaatc ggaaagcgcg gcgccagaaa gaacaagcgg cggaacaaag gccagcaata 2934421 ccgcaatgat caccacagca ggtgtataat acttggcaaa cttcgtgata aagttttctg 2934481 tccgggcttt acggctgctc gcattctgaa ccaagtctaa tatttttgat actgctgatt 2934541 cctgatagcc ctttgtgact tcaatatgca gaacgccgtt ttgattgata aagcctgaca 2934601 ttacatcttg tccttccgca gcttttctcg gaacggactc acctgttaaa gcagatgtat 2934661 caaccatcgc tgacccttgc acgaccttac cgtccagggg tatgctttct cccggattaa 2934721 ccacaatgat gtctcctgtc tgaacgtcct ccgacgaaac ctgttcgatg ccgttctttg 2934781 ttttgagatt ggcgtaatca ggccgtatgt ccattaacgc actaattgat tttctggaac 2934841 ggctgaccgc ggctccttga aaaagctcac cgatttgata aaacagcata acggcgaccc 2934901 cctcagggta ttgctgaatc agaaaagcgc cgattgtggc aagagccatt aagaaatgct 2934961 catcaaacac ctgaccgcgg atgatgtttt tgactgcgcg gattataatg tcaccgccga 2935021 taatcaaata agcaccgagg aaaaggaaaa attcaatggt tcccgactga accaaatatg 2935081 ccgctgcgcc gagaatgaca gccgccgcca ttctgatcag catattgacc attcgattac 2935141 gatagccatc atcagctgat ttctttatat gcttttggcg aaccgttaca tgcggatcaa 2935201 ttgatttcac ttttttctct actttattcg tgacccattg ctcttctttc ccatcggctg 2935261 agacagttaa ggtgcttgcc gcaaaattta ccgcgcatcc gttaatgcct tttatgcctt 2935321 tgactccatt ttcgattttt cgggcacaat tgctgcaatc caaaccgtcc agaacatatt 2935381 cctgtttcac tagtctcacc ttaccttccg atttagggtt ccctcttcaa agcgtatcaa 2935441 tgagtattgt atttatttta tatatatgag catatactca tatataagtt acacctatta 2935501 tatgttgttt tccaagaaag tgtcaatgaa aaacaaaaac cggcatatag ccggtttttc 2935561 attttacttt ttgcagacga agagcattca gaacaacgga aacggagctg aatgccattg 2935621 ctgctcctgc tatccacggt gctaaaaatc caagtgctgc gattgggatg ccgaggctgt 2935681 tatagccaag cgcccagaat aagttttgtt taatgttttt cattgtcaat ctgctcatgc 2935741 ggattgcgtc ggcaatgctg ttcagatcgc cgcgaataag tgtaatgtct gctgtttcca 2935801 tggcaatgtc cgtgccagtt ccaatcgcca tgccgatgtc agctgtggca agcgccggcg 2935861 catcgttaat tccgtcgcct accattgctg tctggcggcc ttctttttgc aagcgggcga 2935921 tttccgccgc cttttgttca ggaagaactt ccgcaatgat attcgcaatt cccgcttcct 2935981 tcgcgatggc ttctgcggtt ctgcgattgt ctcctgtcat catgatgaca tcaagaccca 2936041 actctttcag acgggcaaca gccttccgcg acgtatcctt aatcgtatct gcaactgcta 2936101 ctagccccgc tgcttctcca tcaatggata caagcataac tgttttccct tcggcctcta 2936161 gctcttccat ttgggcgaga agagccccat gctcaacctg ttcgctctcc attaattttc 2936221 ttgtgccgac gagaatgctt tttcctccgg cttcagccaa aatgcctgcg ccgacttttg 2936281 cttcaaagcg ggtaagtttc ggtatctcaa gccctttatc tttcacgcca gcaataatcg 2936341 cttcgccaag cggatgctct gatcccgttt ccgctgccgc tgcaaattga agcaaatctt 2936401 tttcttcaaa acggccgaat ggaatggcat ccgtcagacg cggcttcccg tttgtcacgg 2936461 ttccggtttt atcaagaaca attgtatcga gacgatgtgt tttttctaaa tgctcgccgc 2936521 ctttaaataa aatcccgaat tcagcagcgc gtccagatcc agccattatg ctcgtcggag 2936581 tggcaagacc gagggcgcaa ggacaggcaa tgacaagaac cgcaatgaac ttgctgatcg 2936641 cttcggcaaa atcgccagga gccgcccaaa gataccaaat gagaaaagtg agaaccgcaa 2936701 tccccaatac aatgggtaca aaaatgcctg aaatctggtc agcgagacgc tggatcggcg 2936761 cttttgaccc ttgtgcttcc tcaacaattt tgatgatatg agaaagcgca gtatcctttc 2936821 cgacgttgac agctttaatt ttcagaaagc cgtttgcgtt aacggttgaa cctgtcacgc 2936881 tgtcaccagg atttttgtca acaggaagac tttctcctgt aatcatcgat tcgtcaaccg 2936941 ctgaacggcc ttcaaccact tctccgtcga caggaattcg ttcgccaggt ttgacgtaaa 2937001 caatgtcatt aacaagcact tcgtcgatcg ggatgatttg ctcctgtccg tctcttacaa 2937061 cagtagctgt tttcgcttga agcttcatca gctttttaat cgcatccgag gaacggcctt 2937121 ttgcttttgt ttcaaacaac ttgcctaata aaatcagcgt cagcaaaatc gcgcttgttt 2937181 cataataaag gccgtctgta tgcccgtgag agccaatgct ttgaaaagtt agataaagac 2937241 tataagcgta agcagccgtc gtaccgaggg cgaccaatac atccatattg gcgcttttat 2937301 ttctaagcgc cttatacgca cccacataaa acggccagcc gatcagaaac tggactggtg 2937361 tcgccagcgc aaactgcatc cacggattga gaaatatatc cggtacccaa atgaatgatg 2937421 taaatgtaaa atggctcacc atcgcccaaa gcaatggaaa tgacaggaca gctgaaaaaa 2937481 tcagtctcgc cgtttgcttc cgttcttctt tctttttagc agcagcctca ctgtcctgtt 2937541 cacccttcaa ctttagctta tatccaagct tatctaccgc ttctttcaaa tcgctgacag 2937601 acgcttcttt tggattgtat tcgaccgtaa ctgtttctaa agcgaagttt actggtgcat 2937661 ttgcgacgcc ttctattttg ttaagccgtt tttcaatccg attggcgcaa gccgcacagg 2937721 tcatgccctc aatatcgaat tcagcttttt ctgtaacgac gtgatagccc agcttctcta 2937781 ttttttcctg aatcgctgca gtccctgttt cagcaggatc gtagattaca tttgatgttt 2937841 ccgttgccag attaacattt gcatccgtga caccgggcat ccgcttcagg cctttttcaa 2937901 ttctggcagc acatgccgca caggtcatac cagagacctg catcgcgatt tccttttgtt 2937961 cactcaacat actcactcct ttatatacac ctggggggta tataaaaatg aaagaaatat 2938021 cgcgcctccc taaaggcgcg ataccttgaa tcacttggct acgtcatagc cctgatcttc 2938081 tatcgcatcc gcaatatctt tgactgatac tttgtcagca tcaaacgaaa catcgacttt 2938141 acccgcttcc agattgacat gaacggcact gacgccgtcc agttctccta cgcttgtttc 2938201 tactgctttg acgcagtgct gacaagacat tccttcaact tgcaatgttt tttgttccat 2938261 atcaattcct cctgtttatt ctttctattt tcatcctacc atacccccgt agggtattac 2938321 aataaaaaac gctttatgat tttgtgaact ttttaaatac gtccaaaagc tcagaaatgg 2938381 cctgttcccc gtctccgctt ttgatggcat ctgctacaca atgatgggca tgatcctcaa 2938441 gcaaatgaag cgccacattt ttcattgccg cctgaacagc tgaaatttgc acaagaatat 2938501 ctacacaata tctgtcgttt tccaccatgt tttgaatgcc tctgacctgg ccctcaatcc 2938561 gcttaagccg gtttgtaatc tgatcctttt ctttcgagct tttatggttt aatgttttat 2938621 gttcgttatg cttttccatg cgtacacctc tgtttaatga tattaattcc cattatactg 2938681 attgtccaaa cggttgtcta agcatgccga cgcaaaaaat gaatcagtta ggttttacca 2938741 tttgatcagg agggtatata cttctgttga taacgctttt aaaggggaga agaaaagtgg 2938801 atacgatcaa ggttggaata ttaggatacg gattgtccgg ttctgttttt cacgggccgc 2938861 tgctggatgt tctggatgaa tatcaaatca gcaaaatcat gacatcacgg acagaagaag 2938921 tgaaacggga ttttccagat gctgaggttg tacatgagct tgaagaaatc acaaatgacc 2938981 ctgccattga gcttgtcatt gtcaccaccc cgagcggcct tcattacgag catactatgg 2939041 catgcataca ggccggaaaa catgttgtga tggaaaaacc aatgacagca acggccgaag 2939101 agggggaaac attaaaaagg gctgccgatg aaaaaggcgt attattaagc gtatatcata 2939161 accgacgctg ggataacgat tttttaacga ttaaaaagct gatctctgag ggatcccttg 2939221 aagatatcaa tacatatcaa gtttcctata accgctacag acctgaagtt caagcgcggt 2939281 ggcgggaaaa agaaggcact gccactggta cgctgtatga tctcggctcc cacatcatag 2939341 accaaaccct gcatttgttt gggatgccta aagccgtgac tgcaaacgtg atggcccagc 2939401 gggaaaatgc cgaaacggtt gactattttc atttaaccct ggattatggc aagcttcaag 2939461 ccattctata cggaggatca atcgttccgg caaacggacc tcgttatcaa atccatggaa 2939521 aagattctag ctttatcaaa tatggaattg acggacagga agacgcactc agagcgggaa 2939581 gaaaaccaga ggatgacagc tggggtgcgg atgttccgga gttttacgga aagcttacaa 2939641 ccattcgtgg ctccgacaaa aaaacagaaa cgattccatc agtaaatggc tcctacctta 2939701 cttattaccg taaaatagcg gaaagcatac gagaaggtgc tgcgctgcca gtcactgctg 2939761 aggaaggtat taatgtcatc cgcatcattg aagccgcgat ggaaagcagt aaagagaaac 2939821 gaaccattat gctggagcac taaaacaaaa gcctccccaa ataaggggag gctttttcat 2939881 tagaatgttt ttcctgcttc tttcgcacgc gcaatcgcgt cttctttgat ttgctgtgct 2939941 ttatcaggct ccgcattatg tccctctacg aaaatgccat cgaatgatgg tacgccgaag 2940001 aagttcatca tgatgccgat gtagcggtgc cccatttcca tctcagccgc agggccttct 2940061 gaatagtagc cgccgcgcgc ttggatatga attgcttttt tatcagttaa caagccgaca 2940121 ggaccttgtt ctgtgtattt gaatgatttt cctgcaacag caacagaatc gagatacgct 2940181 ttcatcactg gcgggaatga gaagttccat aaaggagtaa caaatacgta cttatcagct 2940241 gatgcaaatt gatcgctaag ctctcccaaa cggcctactt tcgctttttc gctttcagaa 2940301 agctcttcaa agcctgtacc tgactgaagc tttccccatc cgctaaatac atctgcgtca 2940361 atgtgcggaa tgttttcttt gtacaaatcg atatgtacaa cttcatcatt tggattcgct 2940421 tctttgtaag attcgataaa tgctttacct gttgccatac tgtacgaagt tgcttcgtca 2940481 tgtggatgag cagtgatata taatactttt gccattttta ccagcccttt cgtttttaaa 2940541 aatcacacat caattattat catacagatg cataatgatt attctgtctc tcttagactt 2940601 tattatagag acaaagaaat ttactttcaa gtaaaacatc tcgaattaaa gattatttaa 2940661 ctttcccaaa cagcttactt ttcaaaagct gttctcaagc cggaatacag cgcggacaat 2940721 tctttactga tccgaggata atgagggaca tgcggcactt gaatatccgc aggcatcctt 2940781 ttcatgataa aggattgctc agcctgttca aaaaacgccc gcagctggtt gatctcttca 2940841 tcagaaaacg gagcagacgg acggcggtga gcttgcgccg agagcaaata gtaccctaag 2940901 tgctgagcac cggaaatggc aggccagagc gcatccgcat tcgcgtgagg aaactcgcca 2940961 agcgccttgt catacgcatc ccgaagcctg acaagactca cccttaactt gtgttcgtcg 2941021 gcaatttgcc cggttaacag tttctccata aactgccctt ccagccggat gacattccgc 2941081 acaagttctg gcagccgctt ggttgaaaac cgccgccaca aaagcattgt tcccaacagc 2941141 ccgatcacgc tgccgacagc tacatcagtc agcctcgcta tcataaaata accggcgccc 2941201 gccccgccat gcatactttc tgtgataaca agcgcatttg cggttaaaaa gggaacagcc 2941261 agcgcataat tgcggacgat cagcatctca agaagacatt gcagcgctgc aatacaaaac 2941321 gcaatataaa caccgcccgg cttaaaaaac aggattgcgc ctgccagtat aacaccgatc 2941381 accgttccgg ccgaacgctg aatagccctg tgaagcgtaa aaacaacagt agtgccaagc 2941441 atgaccgctg ctgccgaaag cggaatccaa taggagcgtg caaagccgaa tgcgagggca 2941501 aacatatcgg cggcaaacag aacaattccg tactttaacg ctctaatcaa aactggagac 2941561 ttccagtcaa aggcatttct caaaaagtaa aaagaggatg gcaggcggct tggttccccg 2941621 tcaagctgct tatcaaaacg tcctgaagcg atatacaaaa cctcattgat ttcttcaaac 2941681 agcttccgcc taggctcaga ttcattttca ttaatctgaa acgtattgaa aacccgtgca 2941741 ttcgcaagca tatctccggt ttggcgaagt gccttttcaa tctgcgcggt ctctctgtcc 2941801 ggcgtttcag ctgaaaaatg aataatggca ataaatatgt cgtcagcttt ctcaaggagg 2941861 cgaaaaaatc gttcatcatg ccgcgatttt ttccgtctgt tccctttccc aagaaccgtt 2941921 tggcgggctg ttctaagcat gagcaccgtc tgatgctgtg cgttatgaaa acctggcgtt 2941981 ccgacggctg aaagacatgc agccagctga tgatatgttt tttgcagcac cgctccctcc 2942041 ggtccatgtt tgttccataa ccagccgatt aaagcgatac ccatggcgaa aatgccgccg 2942101 agaaacgtca gtcccgctct gaacagcgct tgtgaaggat cggccggcag cccggaactg 2942161 actaaaaagg caaggacaaa aaacatcggc gcagggcctt gaatgccgag cgcgctaaaa 2942221 ataaacatcg ccgctgcacc gatcagcccc aaaacagccg ccatcatcca aagcatcccg 2942281 gacaaaagcg tccctaaacc aaatgagagg gcgatcccaa tagaaaccaa gagcagcttc 2942341 aaggcgcgct ttttgtacga ttcaccgccc gcatataaat aaacaaagcc tccgatactt 2942401 gcaattaatc cgtaatccgt gtgacctgcc aatgcaccga ccagcacagg aaaccctgaa 2942461 gcgaaacctg atccgatagc ctttttccaa ggaaatggat ttgcatgaat gcgaaaggca 2942521 tccttcacga taggcatgat tctttgattg ttcgcagcag ttttgttcat ttgacaaaat 2942581 ccttttcaat gaatgtgtag aacttttcca gtttcttcgc tttagtatgc ccaaaaacgc 2942641 ggttagcttc tcaattggtg cgcacgataa aaaaacagag acttataccg tctctgcttc 2942701 attacatcag tttattataa aagcggcacc tgtcaggact gttttgtcct tctgccttcc 2942761 ttcaagagca ggtgaataaa aaataaagga taaatcaata gatacccatt aaacagccac 2942821 cacacaagat caaagtcact gctgaatgtc cagaatgata gcgcctgcag acctgaacaa 2942881 caggtcagca caagagaaat cagcgccatc agcttccagt cagcacgatt cacccgctgt 2942941 aggtacaagc tgtacaaccc tgtgacagaa atcaggatat ccagcggaaa aaaagaccag 2943001 ttccaagcga tcataaacgg atggtcatga tgtttaaaag cccagctttc cggtatgagc 2943061 gaaaatccgg ctgacagcca gtacaagata aaaccgatat cagtcacgag aaaaaacagc 2943121 ttcatatatc tcatttgtac tgcccgcttt tatgtaccgg ctcagacacc gcaacatgct 2943181 cgatcaggtt taaagacaca acaccggcaa taatcaatcc aattgaaatg actttcatga 2943241 cactcacatg ttcttgaaaa aacaaaaaac caacgactgt aatcaagaca attcccatcc 2943301 ctgaccatac agcataagca actgatacat caatggattt aagcgtaagc gtcagaaaga 2943361 aaagactccc tccataaaag aaaatcaaca gcaaactggg aataagcttt gtaaaaccag 2943421 acgatagctt catgctgaca gttcccgcaa cctcaaacaa aatcgccaag catagaaaca 2943481 cccaattcat gtggcatcag cctcctcatc agctgttata ccgttaaaca aaacatctac 2943541 aattgattca agtacctctc ctgtcgtgaa ctgatgtttc agcggatatt cagggtcata 2943601 cacttgattg atgctcccta tatacatgtg aacaaacagg tccggattga tgtttctgat 2943661 tctcttttgc tgtttgcact catttaataa tgctaggaca atcgcccatt cttccttaat 2943721 aaacgcgtct aatgtaagcc acgcatcgta atggtatttc tttagttcat ttaataatcc 2943781 catgttcagc agttccatcc cctgcggaag gctgatcagc atttgtttca ccttttcgag 2943841 cacatttaaa ctttcatttt catagatgtc tctttctatt tgcttcattt cagctataaa 2943901 ttgttcgaca accgcctcaa caagctgatc tttagatgaa taatatgcat agagcgtccg 2943961 cttgctcgtt cccagcgctg ccgccaaatc attcatcgta aatgaaaatc ctttctgctt 2944021 gatcagccgg aaggtttccg ccagaattct tttatccata ttaatccccc gctttcggta 2944081 ccaagaaaac tatttcggta ccaatattat acggcagaaa tttatggaaa tcaacaatat 2944141 ataaaaaaac ctctcctatt gggagaggtt taaaagacac tgcggaccaa accgccgtcc 2944201 gcccgaagtg ccgcgccatt gatcgcagag gaaagcggac tgcttaaaaa tgtaacgaag 2944261 tgggcgattt cttccggacg gatcagtctt tgaataatag atgtcggccg gttttctttc 2944321 ataaaacgtg cctcagcttc ttgaacagtc aggttttcac caggatacag cgagttcagc 2944381 atggtttcca caccctctgt taaggtagag cccggcatga cggtgttgac tgtgacattc 2944441 gtgccggttg ccagctccgc caaactgcgg gaaatggaca gctgcatcgt ttttgtcgca 2944501 ctgtaatggg ccatttcctg tgacggcata atcgccgctt cactggcaat gaaaatcaca 2944561 cgcccttctt ttttctctat catgttatgc aaatacctgc gtgtcagcct tacaccgctc 2944621 ataatattca cttcaaaaaa acgaaaccat tcatcgtcgg gaatatcaaa gtactccgcc 2944681 ggttcaaaaa tccctaaatt gttgaccaaa atatcaacct ctggatatgc ctgaaacagc 2944741 tcattgcagc cttcttctgt tcccaaatca aatgcagccg gataaagaac cgcttcagca 2944801 tgttgtgttt tcagttcatc tatcgtttga ttcactttct cttcccggcg tccgttaatg 2944861 atcactgccg caccttcttc agctaacgaa gaggcaatag cttttccgat ccctgatgtc 2944921 gaaccggtca ccagtgcggt ttttccttgt aaattcagct tcattattca tccctccgtt 2944981 tttgattcct cttatttatt gacagaaatc tgattggtga aacatctgct ctgcaatcag 2945041 tatgaaacag ctgggattga aatggaagta cgcacttttt ggtgcctgtg gtttggagaa 2945101 aaaataaagc agaacctctt aagaggttct gctttattgt cagtatgtat ggagacggtg 2945161 ggagtcgaac ccacgtccag aaacatcgat tacttaagcg tctacgagcg tagcctgcat 2945221 atttatggtt tcactcatct tcttgcctgc gggcgggcct tccgagagct agtctgttca 2945281 tctcttctta cgttctcaga cgggaacgca agcgtagcct acttggatgt gctcttcaca 2945341 gacacatagg caatgtcagg aagagctcgc tgcgcttatt aggcagctaa tgctacgttt 2945401 tggttaaaac tgttagtttt gccagttata tttaagtgcg tgtttacgag atcgcctctc 2945461 ggctcgcagc tcaagctcga tccatccctg tcgaatccgt aacgtcccct tggtataagg 2945521 gaaatacggg agaaaatatc aagctctcac tcaaactggc tatagtctta ttataacatg 2945581 atcacggctc ttttcaattg tcaaatcctt caaatgaatg gcgtcgtgat ctgatcgtga 2945641 acacagtata gcacaggcct gattttcgaa tcaagcacta tgcctttaga agcctttttg 2945701 actgtctctg aacgctcttt cgatttcccg cttcgcgtcc ttgcgcttca gatcttcccg 2945761 tttgtcatag ttcttcttcc cttttccaag gccgagaagc actttggcaa agccgttttt 2945821 taaatacagc ttcagcggaa cgagagaata gcctttttcc tttgttaacc cgatcagctt 2945881 attaatctcc ttgcggtgca ttaacagctt tcttgtccgg agcggatcgt ggttatagcg 2945941 gtttccctgc tcatatgggc tgacgtgcat attgtggaga aacacttctc cccgttcgat 2946001 tttggcgaag gaatccttaa ggtttacgcg gccggcgcga atcgatttga tttcggttcc 2946061 ttgcagaacg atgcctgttt cataggtttc ttctataaaa taatcgtggt tggctttctt 2946121 attttgagat aatacttttc ctgacccttt tggcatgcca gaacctcctc tctctaagga 2946181 aaaactgtcc accttttgcg atacgctcta ttttaccaaa tgtcacgtac cgctacaatg 2946241 aaaagctgtt tccgaaagaa agcaaataga gcgctgcggc cctatttgct ggttgagctg 2946301 ctatttcttc tttttccgtt tctgtttcgg agcattctgg aagccgcgtt ttttcttttt 2946361 cttcttcggc ttagtgaacc actccccttt ttcctcagac ggagctggag aaacaggtgt 2946421 attggtgctt tgaacacgtt ttctggcagg ctttccgcgt tttctgctcc ggctgctgtc 2946481 caattctctc ggacgccgcg gagtgccttt catgccgaca atttcaaagt cgatattgcg 2946541 ctcatcttta ttgacatcga caaccttgac tgtgatttca tccccgatgc ggaagacgtt 2946601 gcctgtccgc tcgccaatca ttgcgaaatg ctgttcgtca aagcggtagt agtcatctgt 2946661 cataaagctg acatggacga gtccttcaat tgtattcggc agctcgacga acattccgaa 2946721 gtttgtcaca gagctgatca tgccgtcaaa ctcttcaccg attttatcaa gcatgtattc 2946781 cgcttttttc agatcatccg tctcacgctc ggcgtcaact gcacggcgct ccatagatga 2946841 tgtatgttcg gcgatatccg gcaggcgttc agcccacttt tcctgtgtcg cttcatcgac 2946901 cttgccgttg atcaaatacg ttcggatcag acggtgaacg attaagtccg ggtaacggcg 2946961 gatcggtgat gtgaaatgcg tatagaattc cgttgacaga ccgaagtgcc ccaagctttg 2947021 cgggtcgtat ttcgcctgtt tcatcgaacg gagcataaca gtagatataa ccgtttcctc 2947081 tggtctgtca cgcacagcgt ccagaatgct ttgcagcgcg cgcggatgaa tattccccgc 2947141 cgttcctttc accacatagc caaatgtcgt cacaaattct aaaaactttt gcagcttttc 2947201 agcattcggc tcttcgtgaa tccggtatat aaacgggaca ttcatccaat ggaaatgctc 2947261 cgcaactgtt tcgtttgcta caagcataaa ttcttcaatc agcttctcgg cgacagagcg 2947321 ttctctgatc acaacgtctt taaccgctcc ttcgtcatca acaagcacct ttgcttcttt 2947381 gaaatcaaag tcaacggcgc cgcggtccat ccgcttatcg cgcagaattt gagccagacg 2947441 ctccatgtct ttgaacatcg gaacaagagg ctcgtatttt tgtttcagct cttcatcatc 2947501 atcaacaaga attttattca catctgaata tgtcattctt tccgttgttt tgatgacact 2947561 ttggaagatc tcgtgctctg tcacctgtcc ctgactgtta attgtcattt cacaagaaag 2947621 cgtcaggcgg tcaacctttg gatttaagga gcagatgccg tttgacaatc tgtgcggaat 2947681 catcgggatg acacggtcaa ccagatacac acttgtccct ctttcaagcg cttctttgtc 2947741 aatcggcgag ttttcggtta cgtaatggct gacatcagct atgtgaacgc caagcttgta 2947801 gcttccatca tcaagcttcg tcacggtaac tgcatcatcc aaatccttcg catccgcacc 2947861 atcaatggtg acaatcacct ggtcacggag atcacggcgg tctttcagat ctttttcatc 2947921 aatcgtgtca ggcgtacttg atgcctgttc catcgcgtca gctggaaatt ctcccggcag 2947981 gccgtgctta tgaatgaccg ataaaatatc aatgcccggg tcgtttttgt ggccgagaat 2948041 ggtttcaacc tcaccctctg cgttcatgcg gccttcagga tagctcgtca gcttgacaac 2948101 aaccttatgc ccttccgcag ctccattttt cccatttttc ggaatgaaga tgtcactcgt 2948161 gatttttttg tcgtccggaa tgacaaagcc gaagtttctc gtttctgtat acgtgccgac 2948221 aacccgctga atcgctcttt ctaaaatccg tatgacggtt ccttcctgcc tggagccgct 2948281 tgattgtgag ttcagacgca ccatgacgat atcgccgttc attgccgtat ttagctcatt 2948341 aggcggaata aacacatcac ttaacgacgt atcctcaggc agcaaaaagg cgaatccttt 2948401 cgcatgggct gaaatctttc cttttattaa attcatcttc tccggaatgc cgtagcggtc 2948461 gcttctcgtc cgtacgataa gccctttttc ttccaaggcg actaacgctt tgacgagctc 2948521 tttaaactcc tcggcttccg taatatttaa catctcctca agttcctgaa cggtcagagg 2948581 tttgtacgcc tcttccttca taaacgagag aagcttttcc ataaatgctt ctttttccat 2948641 tatccgacct cctgttgatt accaatcgag cttctctaaa aattcataca catcctgatg 2948701 gacgaggtca cgttctttgt cgagtgtaat gacatgccct gattcctcgt accatttcag 2948761 ctgtttatca tcagtttcca cttcgttgta aataatattg gcgctttcgg tattaatcat 2948821 gtggtcatga cgggcctgca ccacaaatgt cggtgaataa atcatatcga cattattccg 2948881 cacatcagca attaagtctt gcagcgcctt gagggtattc atcggcgttt tttcgaattc 2948941 tttcatttcc tcttcaattt gctccgggct tttcccctca aactttttgt aattgcgagc 2949001 gtatgaaaga acgccttgat acatgacctc ttcactctta atatgcatcg gtgcgcacat 2949061 tgggacaatt ccctttatgg gtacagtgta acccaatttc agcgaaaaaa ccccgccaag 2949121 cgacagtccg caggcagcaa tgctctcata accttcagat tttaaatatt catagccatc 2949181 cattacgttt ttccaccagt cttcgggccc cgtatgtaca agttcttcag gcgggacgcc 2949241 atgtccttca tattgaggcg cgtggcacgt atagccgcgt tcattcaaat atcgtcccag 2949301 catccttaca tccgctgtat ttcctgtaaa gccatgcagc aaaagcaccg ctttgtctcc 2949361 gcctttaaat gtaaatggtt ttggtgtcac aactttcatg ctcatgtctc cctttctatc 2949421 tgcacgatca ttttagtttt ccacagttta atcagaaaaa aacgttttga atatcatcca 2949481 gaaacgtgaa aaaggcctga cttcacatca gaccttatac aaacattgcc ctataggata 2949541 taagcaagcg caatcgttaa cacgaaaaac aagactgcca gcactaccgt aatgcggtgc 2949601 aaaattaaat caagacctct tgctttttgt ttcccgaaga gctgctccgc tccgcctgaa 2949661 atcgcaccag ataatccggc acttttactg gattgaagca aaacgacaat aataagtgca 2949721 atgctgacga taaccaataa ggtaatcaaa actgcgtgca tcccatacac ctccagactc 2949781 actggctaca ttacttctat tttacatgaa aagggttggc atgtcacgct gtatcagacg 2949841 ccaaaaggcc ggataagacg ttttatcttg gttaccctat tcatatgaaa aggtcaaagg 2949901 agaaaagcga tgccgcttat cagcatagac agcaggaaac atctttttta tgaagaatat 2949961 ggacagggaa tccctatcat ttttatccac ccgccgggca tgggacgaaa ggttttttat 2950021 tatcagcgcc ttctatccaa gcatttcagg gtgatttttc cggatttaag tggccacggt 2950081 gatagtgatc acatcgatca gccagcgtct atttcctatt acgcaaacga gatcgcgcaa 2950141 ttcatggacg ctttgcacat tgataaagct gtgttattcg ggtattctgc cggaggctta 2950201 atcgcgcagc atatcggctt cacccgcccg gacaaagtgt cacaccttat tctgtccggc 2950261 gcctaccccg ctgttcataa cgtaatcggc cagaagctgc acaaactggg aatgtatctg 2950321 cttgaaaaaa accccggttt gctcatgaaa atcctcgctg gcagccacac aaaagacaga 2950381 cagcttcgca gcatattaac agaccatatg aaaaaagcag accaggccca ttggcatcag 2950441 tattatctgg attcgcttgg ctacaactgc attgaacagc tgccccgcct agaaatgcca 2950501 atgctgttta tgtatggcgg cctgcgggac tggaccttta caaacgcagg ctattaccga 2950561 agatcgtgca gacatgccga atttttcaga ttggaatatc agggacatca attgccgaca 2950621 aaacaatgga aaacgtgcaa tgagctggtg acagggtttg tgctgacaca tcattcatag 2950681 gaatagaaaa cgcttggctt ccttgcgttt tttgttactt tattgacttt tgtcaacgaa 2950741 atcatagtaa aaaagatcct caaatttcaa attaaaatag tgaagcattt taccaatcac 2950801 aagctgcccc ggccttcttt ctccattcag cacgcggctc agtgtggcgg gtgagactcc 2950861 gatttccagc gcaagctgat taagggaata atcgttatta accatatact gcaagacata 2950921 atcacgtcta atctgtatct tttctactgg cactttcctc accttccatt cctgaaaaac 2950981 ttttttctat acttttacat tacggcttat gttaactttt gtcaatacat ttccagtcta 2951041 cctattccct ttagtcaata aacatactaa aatatgagta acagtgaggg acggggtgag 2951101 atatatggaa agctttggcg aacaattacg ggcattgcgt gaagagagaa agttaacagt 2951161 caaccagctg gcgacttatt caggcgtaag cgcggccggc atctccagaa tcgaaaacgg 2951221 aaaacggggc gttcccaaac ctgccaccat caaaaaactg gcagaggcct taaaaattcc 2951281 ttatgagggg cttatgtaca aggctggtta catcgaagaa gtgcatgaag ccagggcccc 2951341 ttatgaaacg aagtgcaagc tgcttgaaaa agcggaggcc tatgacctga aaaaccttgc 2951401 gcttcttgag aacgaaaagt ggcaatatct caataaagaa gatttgctca tgctggatca 2951461 ttatttttcg tttatttcag atgaagcgaa aaaacggtct gctgatgact gactcttgat 2951521 agaaatgtga ggcgatagac catgtcaccg ttcggacagc aattacggga gctgcgccgc 2951581 gcccgcaaac tgacagtgaa tcagcttgcg gtgtactcag gcatcagctc ggccaccatt 2951641 tcaaaaattg aaaacggcaa acgcgggacg ccaaaacccg ccacgattaa aaaactggca 2951701 gccgtcctga aagtgccgta cgaaaaccta atggccgccg caggccatat tcaggccttt 2951761 cctgaagaaa tccgcgaagc atctgaaggc tatcaatccg tttatgaaat ttaccagacg 2951821 gctgtcacac gcggagcgga gcacctcccg attttcaata gtcaaaaatg ggaacatctc 2951881 tcaaagcagg atattgaaaa tctcagcaaa tacttcgatt ttttgtcttc agaagcaaaa 2951941 aaacgcgcct cttcctcata atcccctgtt tctctttcta tattttatca atcacgcttg 2952001 catgccctcc ctcgttattt gcgttataat agtgacagac gaggtgaaaa gtatgaacca 2952061 atcagaaatg tgtcctagat ttgaaaaagc agtcgacatc ttaagtaaac gctgggtcgc 2952121 tttaatcgta tttcagctct tgaacgggtc gcagcgattt agcgaaattg aagcagcact 2952181 tccaaatcta agcggcagag ttctgtcaga acggctgaaa gaacttgagc ttgaaggagt 2952241 agtgaagcgg gatgtcatcc ctgaaactcc ggttcgcatc gaatattcat tgactgataa 2952301 aggaaaggca ctagcaccca tattaggtga gatttctaaa tgggcgactg aatggattga 2952361 cccttccttt cttgactaat tgctaaaatg gttctgatct caaagacgag aaaagaaccg 2952421 ttttttattt tccaggtgaa aaaaagatat ctcagccgat atatagtaca tccacacatt 2952481 acgtttttaa aggagaccac tatatgcgac tgacgatttc ccgcaaattc agcctggtat 2952541 ttttgacact gatcctgatc aatttacttg taggcggaat aggcgttctt aatatgcagc 2952601 atatcattca aaaaacagat gaaatcaaca caaaatggat tgacggcatc aaaggaatca 2952661 cttcaattaa ttatgtaacc gagcacctgt cttctaaaga aaaggacttt ctgatttata 2952721 cagacaaaag taaaatggat acacttgatc aagaaatgaa tcaaatcatg gaagacatta 2952781 accaaaagct cgataactac gaaaaaacga tctccactga taaagagcag aaactgttcg 2952841 agcagcttca aactaaagtg aatacctata tggatattca tgcgcaaatt atcgaaagcg 2952901 gccgcacgaa tgacatggac aaagcaagag gtttattggt tcagactgag gccagctttg 2952961 aggatatgaa aaaaacaatc actcagcttg ttgacttaaa tcaagaaggc agcaacacag 2953021 cggtaaaaga aacgaaggcc gtctatcata aagggctcat ttacactgct ttgcttgtgg 2953081 cagcatcaat cctcatcagc attttcatct ggctttatat cacgcgaaac attgtaaagc 2953141 ctatcattcg catgaaggaa tctgccaatc atattgccga aggcgatttg tcgaacgata 2953201 tggaggccct caactcaaaa gacgagctgg gtgatctgaa tgaagcgctg caaaaaatgg 2953261 tagggaatct gagagatatt gtcggatatt ctaaagacat atcaagccgg gttctttctt 2953321 cttcacaggt gcttgcaacc gcaacgaatg aaacaagatc cggcagcaaa catattaccg 2953381 agacgatgaa cgaaatggct gagggctctg aacagcaggc ccaagacgcg gtgacgattg 2953441 ccgaatcgat gaatgagttt accgaaagca ttgataaagc ctataatcac ggcatcacaa 2953501 tcagcgatac gtctcaaaac gttctcgaac tcgcggtaag cgggaacgaa aatatggcta 2953561 cgtcattaca gcaaatgaaa accatccatc atattgttga agaagccgtg cataaagtga 2953621 gatcactgga acagcattct caggatatta acaagctcgt tcaggtcatc aacgggattg 2953681 ccgagcagac gaatttgctg tcccttaacg ccgcgattga agctgcccgc gctggagaaa 2953741 gcggcaaagg cttcgccgtt gtggcagagg aggtcagaaa gctggctgac ggcgtttctg 2953801 attccgtgca ggacattacc cggattgtaa acgggacaca gcaggagatc cacactgtca 2953861 ttacgtactt ggaaagcagc tttacagaag tcgaaaaagg aacggaaaac ctgacagaca 2953921 ccggacaggc tatgcagcat atcaaacaat ccgtcaccca tgttgcagac agcattaagg 2953981 aagtaacgga tggcttgaag cagttaacaa accaatcgat taccatcaat caatcgattg 2954041 aaaatatcgc ttctgtatcc gaagagtctg ccgccggcat tgaagaaaca ttttcaatta 2954101 ccgagcaatc cgcccattcg atggatcaag tgcttctaaa tgctgaagag cttgagcagc 2954161 tggccaatga gcttaatgag aagatgggtc agtttacgat ttaaagagaa aaaagaggct 2954221 ggactccagc ctctttttct attctatgca gctgattgaa catgtttcgc cccggttctt 2954281 tttttcttca ccggacttaa tgcccgctcc agccaagcca tgagcaaatc cgcccctacc 2954341 gccatcaccg cagttggtat cgctccggct agaataatcg cagttccgtt tgttgcgttt 2954401 gagccgcgta cgatcatgtc cccaaggcct ccggcaccga caaatgtgcc gatcgctgta 2954461 attccgatgg caatgacgag agccgtgcga aggcccgcca taatgacaga aagtgcgagc 2954521 gggagctcaa ccattctgag cacttggaat ttcgtcatgc ccattgcttt tccagattct 2954581 aagtaggcat gttcaatact gataatgcct gtgtacgtgt ttcgaataat cggcagcagg 2954641 gaatacagaa ataatgatag aatcacggta tttgcgccga gccccataac aagcattaag 2954701 acggccagca tagcgagcgc cgggattgtt tgaataacgt ttgttacggc aaacacccag 2954761 gctgacaaac ggcgaaaatg cgcgatgagg attccggccg gaaccccgac gacagcggca 2954821 aataaaacgc cgtaagccga catgagaaag tggcggccga attcatccat gacgtaactg 2954881 ccattctgcg cgtaatacgt cattaactgt tcaagcacgt tcattgacct cttccccctt 2954941 tcacgattcg aaatagcgat gtttttctaa atattccttg gcaacgacag acggttcttt 2955001 gagattgccg tcgacttcat agttaagctc ctgcatcgtg gctgtgtcga tttttccgag 2955061 cattttcttg atgatgcctt caagttcagg atgttctttg agcacctttt ccggaacaac 2955121 cggagagcag tcgtacggcg ggaaaaattg tttatcatcc tttagcattt tgagaccata 2955181 ggacttgatt cttccatcgg ttgaatacgc aagcacaatg tccatttttc cgcttttcac 2955241 cgcgtcgtac acaaggccga tctgcatcgg atacgtgccg ccgaatgtca tgccgtaggt 2955301 tttcgtaaaa tcctgatagc cgtttccttt gagcttcatc caatagttat caacgcccag 2955361 ctttaattgc ggcgcccatt ttttaacgtc tgatacggtc tctaaatggt attggtcggc 2955421 cagctccttg ctgactgtaa aggcatatgt attatcaaac ccgtaggagt cataccactt 2955481 taaatcatat ctttttttaa actcccgctg agtaagcgcc agcgctttgt ccggatcttt 2955541 ttcaggttcc attctcaacg tgcctgtcag cgcgtctccc gtatatcttg tggccgcaat 2955601 gtcgatttcc ccgttcatta aagcctgctg ctgcaccgcg ttggagccaa gatttttaat 2955661 cgttgttgtt ttgagatcag tatggtgttc gatcaactgg ccaagcatgc tggcgatgat 2955721 ttctgattcg ctcatgcttt gcgcgccgat tttaatggtc tggtctgcag cagcgctgag 2955781 accaggaagc gaacagccgc tcagcgtcag cgttgccgca agtgctaaac ctatcattaa 2955841 tttgagatat tttcttttca tgagccgcct ccttatgaca attccttcaa tctctgcatg 2955901 ccggcaggtg tcagttttcg ttcagcaact gccagcacat aatcaatcac aattgccaat 2955961 atcgtgacag gtaccgcgcc cccgatgata tattccggct gatataaatt cagtccgata 2956021 aaaatgtaat cacccaatcc gccgcctccg ataaaggaag caagcgtggc ccagccgatt 2956081 aagtaaatcg tcgatgttct gattcccgcc atgatcactg gtgcggcaag cggcagctcc 2956141 accaagcgga cttgttcagc cggcgtcatt cctattcctt taccagactc gagcagattt 2956201 ttgttgacgc cgcgaatgcc ggtatacgtg ttgcgaagaa tcggcaatac ggaatagaaa 2956261 aacaaagcca caatggccgg aaccttccct acaccaagga gcgggataaa aaaagcgagg 2956321 atggccagac tcggcagcgt ctgaatgata ttgacaatgc cgataatggt gccggctcct 2956381 tttttcattc tggtaagcac aaccccgagg gggacggcaa ccagcacacc taagatcaca 2956441 gcaatgagcg atatcgtaat atgctcgtat gttttataaa gaagctctcc cccattggtt 2956501 tgcaaaaatt gaacaatatg atgcatgact tatcgcccct ccctatgaca atgctgcgag 2956561 ctgcttttct tctccccaga gggagtcata cacgatgtcg accagacttg ccctcgtcac 2956621 aattccgatc aggcgtcggt cttcatccac aacgggaaca tatttgacac cccgttttaa 2956681 aattttgcgg accgtgtcgc gcagcagtgt gccgcccagt actgtgtata tatcttcatg 2956741 taaaacttca ctgacgagat tggccttttt ccggcattga tcaatgattt caacatcgac 2956801 atagccttgc agaacgcgct cgtcattgac gaccagcaat gaatcgaccc gttcctgcct 2956861 catcagctga atggcctcag aaagcgtttt atccgcggtg atcgttacag gctgtgtgtt 2956921 cataatctgg tcaacccgtt caacatccgg gctggatgac tgaatcagcc gctccttgcc 2956981 gataaattcc tcaacaaatt cgtctgccgg atttcttaaa atgtcatcgg gcgttccaac 2957041 ttgaacgatt tctcccgctt ttaaaatcac aatccggtct gccagcttaa tcgcttcatc 2957101 catatcgtgg gtaacaaata cgatggtttt atgtaaggtt ttttgcagtt ttttaaattc 2957161 ttcctggagg gaatccctcg taatcgggtc gagtgcccca aacggttcat ccattaagat 2957221 aagcggcggc tccgcggcaa gtgcccgtaa tacaccaatt cgctgctgct gccccccgct 2957281 taattcatga gggtaacggt ctacatattc tggccccata tcgaccaatt ttaaaagctc 2957341 acgcgcccgc tctttccgct gctgctccgg ccatttcagc agttttggga cgagtgagat 2957401 attctgctga atggtcatat ggggaaacag gccgatctgc tgaatcacat agccaatttt 2957461 gcgcctgagc tctacaggat cctggtccat gatgttttcg ccgtcaatga aaatcttccc 2957521 ggcggaaggc tcaattaatc ggttaatcat tttcattgtt gtcgtttttc cgcagccgct 2957581 cggcccgata aagcagataa attcgccttt tgcaatctta agatttacgt tgttcacggc 2957641 ttttttgccg cccttgtatg ttttcgagac attttctaat gtcagcaaac atcgcacctc 2957701 caaaattaag tttattcaat ttgttcagtt taaatttaat ttttcagaca attgaatgct 2957761 tcccattata gaataaagtt tataaaataa aaagtttaca atttgttcat attatttata 2957821 aagtatgtgt aaacgctgat ttacccgcat tgacgtgtgt tgatctcctt attgctccaa 2957881 tttcctgcca aattctcttt tgacagcatt ttcgccgtat caaaaatgtg gtatattgac 2957941 atcggaattg ttagctgaaa ggatgaaacc gttggagaaa gatccgttaa cgatcattga 2958001 acaagccgag gaccatttta tagaaagaat cgcggaaaac atgcatgcat ttggaatgcc 2958061 ctctaccgtc ggacgagtgc tgggcattat ttatatgaat cgaaaaccga tgacgcttac 2958121 ggaattatct gaggccaccg gcatgagtaa aacacgtatg agccaggtag tgcgggaaat 2958181 gcttgatgcc aacattgccg agaaggtatt cgaaaaaggc gtgcgaaaag atttatatga 2958241 ggttgagcag gactactatc aaacatttat cacgctgttt tcagccacct ggagcaaagt 2958301 cgtcagcaaa aacaaaatga tgcataaaaa actcaatcgg gagctgctta gcgtgttgga 2958361 tgaagagctt actcctgaag cggaagaaaa agtgaatgag ctgctgaagg aattaaagga 2958421 atggctcgat tattataatt ggctcagccg tttgattgag ttttttgaga gcgaagacat 2958481 ttttaaatat gtgccgaagc cgtaaaaagt tcccaaattc aattctggga acttttttaa 2958541 gtccaatcca aatggttgaa tatcaaactt cgagctccca acgctggaaa atatgtttaa 2958601 cagatactaa cacatgttgt ttatttaaaa aaaccacctc tgttgtattt aaatagaggt 2958661 ggtttttcta tcagctataa taaaatttcc ttttttcttt ttaatcgggc ttaatgctcg 2958721 ttcaagccag cccatgacca aatcggcaat caccgccatc agagctgtgg ggatcgctcc 2958781 cgctaatata atcgcggttc cgtttgtggc gtttgatcct ctgacgatga tgtccccgag 2958841 accgccagca ccgacaaatg tcccgatggc cgtaatgccg atcgcaatga caagcgcggt 2958901 gcgcaggccg gccattatga cagaaagcgc aagcggaagc tcgaccatcc gcagcacttg 2958961 aaattttgtc atccccattg cttttcccga ttcaagatag gcgtgctcaa tactgataat 2959021 ccctgtatac gtatttctga taatcggcag aagagaatac agaaataatg acaatatcac 2959081 cgtattagcg cccagcccca tgacaagcat cagcacggcg agcatggcga gagccgggat 2959141 ggtctgaatg acattcgtga ccgcaaaaac ccatccgctt aatcttctgt atctggctat 2959201 caggatgccg agcggaattc caacaatggc ggcaaataaa acgccataca ccgacatcag 2959261 aaaatggcgg taaaattcct gcagcacgta accgccgttt tgcgaatagt atgtgccaag 2959321 ctgctgtagt acttccatat gatccacctc ttttcttagt caaaataatg atgtttctct 2959381 aaaaattcct ttgctacgac agacggctcc ttcagcttgc catccacctc ataattaagt 2959441 tcctgcatcg tttccgtgtc gatttgccca atcagcttat tgatcacacc ttcaagttcc 2959501 ggatgctcct taagcacctt ttccggaatc accggtgaac agtcatacgg cggaaagaaa 2959561 cgcttatcgt cttttaagat tttcagatca tatgctttaa tccgtccatc cgttgaataa 2959621 gccaaaaccg catccatttt cccgtttttg actgcgtcat agactagccc gatctgcatt 2959681 ggataagttg tgccgaactc aaagccatat gtgctgacaa agcctttata cccgtcgcct 2959741 tttcgtttca gccaagcatt gtcgacgcct aatttatatt gggaagcatt tttcttcagg 2959801 tcagacacgg tgttaatatg ctccttttcc gcaaactttt ttgttacggt gaaggcatat 2959861 gtgttatcaa agccgtagga atcaaaccat ttataagaaa agcgcttttg aaactcgttc 2959921 tgcacaatgt tcagcgcttt tttcggatct ttctccgctt ccttgccgag ggtgcttgtt 2959981 aaatctgttc cggaatagcg cgtggctgaa atatcaatgt caccgcccag catcgcttgg 2960041 tgctgaacat agtttgagcc gaggtttttc actaaagcag tattcaaatc tgtatcatgt 2960101 tcaataagct gcgcgatcat attcgctaca atttctgatt ctgtcatgct ctgcgccccg 2960161 attttgatcg tatcgtcaga agcgccgcct agacccggca gagagcagcc gcctagcagc 2960221 atgacaaaga cgagagcaaa cgcgccaagc catttgattt ttgtcatttt caacagtgcc 2960281 aactccttac gatacttcct tcatcccttg caagcctttc ggcgtcacct ttcgttctgt 2960341 cacagccaga acataatcaa taataattgc cagaattgtg acaggcacgg caccgccaat 2960401 gatatattca ggctggtata ggttcagtcc gataaaaata tagtccccga ggccgcctcc 2960461 cccgataaac gacgcaagtg tcgcccagcc aattaggtag atcgttgatg tgcggatccc 2960521 cgccatgatg atgggaatcg ccagcgggat ttcaacgagc cgaatctgct cccagccggt 2960581 catgccaatt cctttccccg attccaggag gtttttattt acacctttaa tgccggtata 2960641 cgtattgcgc aggatcggca gtaccgaata gaaaaataaa gcgacaatcg caggcacttt 2960701 tcctacgccg agaagcggaa taaaaaaggc taaaatcgcc agactcggca gggtttgcac 2960761 aatgtttacg aaaccgataa ccgcacctgc gccttttttc attctggtaa gagcaacgcc 2960821 gagcggcact gcaacgataa tgcccaatac aacggctatg agtgaaatat ataaatgctc 2960881 tcctgtttta tacagcagct ctccgccgtt cgtttgcaaa aaagtcatca tttgattcat 2960941 cttaaaagag ctcctcccct ggtcagatcg tcatgagctg gttttcctcg tcgccccaaa 2961001 tggaatcgta tacgatatca acgaggctcg ctcttgtcac aatccctgct aaatggttct 2961061 gttcatcgac caccggaaca tacttgatcc cctgcttcaa aatttttcgg actgtatcgc 2961121 gaagaagcgc ccctttttga acggtatata tatctgaacg gtatacatcg ccaacgatgc 2961181 tcgctttttt gcggttttga tcaatcattt ccacatcaac atagcccttc agcacgtttt 2961241 gccggtccac aacgagcagc gagtcaacac gtttttctct catcagctga atcgcctgag 2961301 aaagcgtttt gtccgcagat accgtcaccg gcgttctgtt catcatttgc tctacccgct 2961361 cgatatccgg tcttgactga atcaggcgct ctttcccgat aaattcttca acaaactcat 2961421 ttgccgggtt tcgaagaatc tcatcaggtg tgccgacttg aacgatttct cccgctttta 2961481 atatcacaat cctgtcagca agcttaatcg cttcatccat atcgtgggtt acaaacacaa 2961541 tcgttttgtt taaggttctc tgcagttttt tgaattcttc ctgaagggaa tcacgcgtaa 2961601 tcggatcaag cgctccgaac ggttcatcca ttaaaatgag agggggttcc gctgccaggg 2961661 cgcgcagcac gccgattctc tgctgctgtc cgccgctgag ctcatgcgga taacggtcta 2961721 aatactctgg gcccatatcc acaagcttta acagctcgcg cgcccgttct ttccgttttt 2961781 cctcaggcca tttcagcagc tttggtacga gtgagatgtt ctgctggatg gtcatatggg 2961841 ggaacaaacc aatctgctgt atcacatagc cgatttttct cctcagctca accgggtcct 2961901 gttccataat attttctccg tcgataaaga tccttccaga cgatggttct atcagtctgt 2961961 tgatcatctt catcgtcgtc gtttttccgc agccgctcgg gccgataaaa cagataaatt 2962021 caccttttgc aatatctaaa tcaatgctgt tcacagcttt tttgccgcct ttatatactt 2962081 ttgacacttg ttccaatttc agcaatccgt gcacctccgc aggtttcctt taaattttct 2962141 gaaaagtata atccttatta tagtttgaac tttgtaaaat aaaaagttta caatgtgttg 2962201 aaattatatg ttatttatag attatttatt gttatgaccg agacggaaag ggtgttctta 2962261 caattactcc ggatacctcc cacttcctct gcattcagct attttcaaca ccaggaagaa 2962321 atatgatata ttgacaccat caattgccat ttgaagggat gatcagctgt gaaaaaaacc 2962381 gctctcgaca tcattgaaca tgctgaagag catctcattg agaagattgc cgaaaatatg 2962441 catacgtttg gaatgccttc aactgtcgga cgtgtgctcg gaattattta tatgaatcga 2962501 aaaccaatga ccttaagcga gctctctgag gcaacgggca tgagcaaaac acggatgagc 2962561 caggttgtcc gggaaatgat cgatgccaat atcgccgaaa aggtgtttga aaaaggcgta 2962621 cgaaaagacc tttatgacgt cgagcaggat tattatcaaa ccttcatttc tttatttgcg 2962681 gcgaattgga caaaggtcgt gagcaaaaac aaagtgctgt ataaaaaatt aaaccgggag 2962741 ctgagtgatc ttttacaaag ggacgggctt accccggaag cggaagagaa agtcaatcag 2962801 ctgctgaatg aattaaaaga atggcttcat tactatgatt ggctgagcag gttgattgaa 2962861 ttttttgaga gtgaggaagt ctttcggtat gtgccgaaaa caaaagaatg cagctctcta 2962921 aaataagaga gctgcttttt gcatcatgaa gttaagaccg gaaacatgcc tttcagcccg 2962981 gcaccaatca tcccgaccgc aaccacggct aagattaatc ccatcagtct ggtaatcaca 2963041 ttcatctcgg tttttccgag tttgctgctg ataaaagcag aatagtggaa aaagagaaag 2963101 gtcagggcaa taacggcggc tatgccgatc atgacagccg cataatgacc aatgccgcta 2963161 tgtccggcgg aaaggctcat cactgttgca atcgttccgg gcccagcaat gatcggaatg 2963221 gataaaggtg tgactgatat atccgctttt tccttgcttt ccttatgttc atcatggtga 2963281 agagattgca cgtgcgattc tttcgcattc aatagattat aggcaatgcc gaaaatgaat 2963341 atgccgcccg ccactcggag cgcgtgaatg ttgatatcaa acagtttaaa gataagatga 2963401 ccgaaaacca aaaaagctgc gagaataaaa aaggataaaa tagctgcctt ccgggcaatc 2963461 gcttttcttt ccgctgcagt atagccttct gtcagcgtca gaaatatcgg tacgtttccg 2963521 atcggattcg atactgcgaa taaagaaatg aagacgtgaa cgataaatga gaacatcata 2963581 tacctccttg ttgatagtct ctgcacagga aatagaatga ttctccaccc ttttacccgg 2963641 aggcgatttc ccggtaaacc tttatagcct gtcagaaacg cgccatgcta caatgaagtg 2963701 acaaattgaa taggaaggac gtatacagat gttcaaaaaa attgcggcag atgccttggg 2963761 cttatctgat atcggaaaaa ttatcgaacc tcaggactat gacaaaacag acgcagatga 2963821 ctatgtcatg catgaagata atgagaaaat ttatttcttg attaaaacaa aagcagacga 2963881 gtattgcttt acgaacctgg ccctgatcca tgtggacggc gaacgcgcca cttcctcaaa 2963941 acgaacgttg aaacgctatc cttattcgca atataaaatc tctgacgttt ttcttgaaac 2964001 tgccggaaaa gtggatttgg atgttgaaat taagttcaag ctgggcggtg aacaattcga 2964061 cattgatgtc cacaaagacc agattgaaaa gttaaaagac ctttataaag cactgcttcg 2964121 catcgctgaa acaacctatg aaaatgacat tttaatcaat caagcggagc aaagcttaga 2964181 taaagcagtg acgattcttc accatacccg ccctgagcac gtcaatattg aaacgcaata 2964241 caaagagctg accgaattcg gattcacttg gctgacatcc gttcgctcgc agtatcatat 2964301 taaggatttt ggggatgtat ttgagaaata tattaataac tagataaaaa aagacacagc 2964361 tgctatcgtg ctcgtgtctt tttttgtatg aatattgatt actttacaac ttttttcttt 2964421 tataataaaa ctattagtct attttcccta tattacagat aaaggagtta ttttatgtat 2964481 tgtcctcaat gcggccatca aacagatggc ggaaattttt gtgagaaatg cggatcaccg 2964541 ctccccggtc aatcaggcca ccagcatgca gctcaaactg gagccgctgc aaagcaagca 2964601 gcaaaacagt tcggttcatt tgtcttatcc gtcctgaaac gcccttatca ggaatgtaaa 2964661 gcaacaggcg gagaacagct gatcagcgca atcattacga tggttctttt cagtttgctg 2964721 acccctttga tgttttatat tcttttttca gacggtcccg gaagcgtaag ctttacagca 2964781 atcttcttag agccaaccat ttattttatt ttatttctat ttggcctgca tgcatgcatc 2964841 tttttcgccc tgaaaatcgc gggaaaccaa gtgtctttca aggattcatt ctcaagattc 2964901 ggagcatttc ttattccttt tacggctatt ttgattcttg cccttttctt ctttttatta 2964961 catacagaca tttgctttac catattagcc gttggtttaa tcggtgcatt cttcgccatt 2965021 cctcctgcga tgctgagcag ttaccagcat tcatataaag ggaaggttga tttcatttac 2965081 tcaacgattg tgatttatct gatcatctgc gttacatttc agcttattat cgaacactat 2965141 gtcaaagaaa ttttccgtta tatgctcttt taaaaacaac cccatcacct gctggtgatg 2965201 gggttgtttt attgaataga cgttaagtaa attcttccgt tcttcactac gccggtgtag 2965261 gtccagttat atgttctgag ctttggactg ccgcctgatt ttgtgatata gaattcttca 2965321 tacgtcttaa tcgtgatagc cgacccattt tggctccagc ttttcacttc atagttatta 2965381 aagtcttctg ttgtcccctc tttatttaat ttcgacacga gatgctgctg gtcggaataa 2965441 agggaactgc ctttttcaag gctgtcttcc atcagtgaga aattattttg attcacggca 2965501 tctgcctgac tttgcagata actgcccata aataatgtca cttgttcatc tgtaacatcg 2965561 ccgcttgcag agctttcact gcctttgttt ttcgagccag cccaggcgga agtgtatgtc 2965621 tctggtttat catttttgat tttctttata tttgtgcctg cagattcgaa tgttgattct 2965681 gcatcttcga aaatccactt tttctgtttt ttatcatatg aaagaagata ttcataactc 2965741 ggactgtcgt cagtcatttc agactttgta tagtcgttat acgaagaaga ctggtgaagt 2965801 tcttttcctg ttaccgatac ctgccacgtt ccgtcgtttt tctgagagag ggcaaatgtg 2965861 tccaggtcaa aatcagtttc caagtatcta tcttttaagt atgaatccgc gcttttcata 2965921 gaatcgacgg tgtccttcgt ctccgccttc caattggcac ttgcctctgt catctgggct 2965981 gtattcccat cagatagagc tttggagtat tgttttgttg ttttgacaat tgtgttcata 2966041 atctgttcct gtgtatcttg atcaggaatt aacgttaact ccatttcttt atcatcgatc 2966101 ggaacgccgg cagtttttgt ttttccccac ggaaattctg cctcgactga agctgtcatt 2966161 gatccatctg tcagcagcgg accatatgtt acggatttga acggatcttt atgaattgat 2966221 ttaccgttaa tcagcaaatc tcccttcccg ctcttgatgt cattcgctaa gctgaatgtc 2966281 acatcgtctg cttccaatga gagatcaaca cgaaagctgc tatcgccaat cgcctgaatg 2966341 tcttcctttt tcacaaggtc aacgacatcg tttttcagtt tggctgagac tgtatattcg 2966401 ccgggaatgt acggaccaag ggtttgtgct tgatctgctt tctttacaga tccggcttcc 2966461 tctttattga catatagatc ggtattttta taattgctgc tcacttcaaa ataaacaggt 2966521 gctaccttta agtcataatg gtcaaatacc agcaggcttt tcccgtcttt ttccgcatat 2966581 acgatatcct tctgggctgt ttcatcacgc agcgatgcaa aaagttcatc ttttttgtct 2966641 ggatgatcct tcaaatatgt aagaaacggt tttacattat ttttagtgag tttaagattg 2966701 tcatttaccg gtgtaagcag agtcgcgatt tggtcctgat ccccatcatt tacggcctgt 2966761 tcaaacttgt ctactaacct atcctttgaa gtaaaatacg ctccggtttt atatgcggcg 2966821 aataatataa cgcacgccgc ggcaatgctg ctccataaaa tgatggtttt cttagggatc 2966881 ggttttcgcg gagcctgcct cgtttctgca gtgctagctg tttcttgatt tgcctgtttg 2966941 ctgccccctc cgatcggggt gccgcattgt ttacaaaact tggctccttc attattctgg 2967001 gagccgcaat tcttacaaaa taacatgact ttcctcctat tctactaatt tgataacatt 2967061 tactgctttt catattttat aataaaacag aatgaaattg ggaacgaatg aaaaaattaa 2967121 atgtctatca gactaaaaag gtggaatgaa tatgcaaaag ctcaggattg aattaggaga 2967181 agaaacaaat gacgaattat atgatctatt gctgctcgcc gatccatcga aagacattgt 2967241 agatgaatat cttgagaggg gagaatgtta cacagcttgg gccggtgatg agcttgcagg 2967301 ggtttatgta ttgctaaaaa caaggccgca aacagttgaa attgtaaata ttgcggtaaa 2967361 agaatctctt cagaagaaag gctttggcaa acagcttgta cttgacgcca tcgaaaaagc 2967421 gaagaagctg ggggcggaca cgattgaaat cggaacgggg aattcgagca ttcatcagct 2967481 ttccctctat caaaaatgcg gattccgcat tcaggcgatc gaccacgatt tctttctcag 2967541 acattatgat gaggacattt ttgaaaacgg gattcaatgc cgcgatatgg taaggcttta 2967601 tttggatctc tgaaagcata aaaaagccgc cgagagaaaa tcccggcggt ctttttatta 2967661 cttgtttaag ttgtagaaag agttgatacc gtggtattga gcagtttcag ccaactgatc 2967721 ttcgatgcga agaagctggt tgtatttcgc aacacggtcc gtacgagacg gagcacctgt 2967781 tttgatttgt cctgcgtttg ttgccacagc gatgtcagcg attgtgctgt cttcagtttc 2967841 accagaacgg tgagagataa cagctgtgta gcctgcgcgt ttcgccattt cgatcgcatc 2967901 gaatgtttca gtcaatgtac cgatttggtt tactttgatc aggatagagt tgcctacgcc 2967961 gtttttaata ccttcagaaa gttttttcgt gtttgtaacg aagaggtcgt caccaacaag 2968021 ctgaactttt ttgccaagac gctcagtaag aagcttgtgg ccttcccagt cgttttcgtc 2968081 aagtccgtct tcgatcgaga tgattgggta tttagaaaca agctcttcat accagtcaac 2968141 catttcagca gatgttttca caacgccttc gccagacaga tggtatttgc cgtcttcttt 2968201 gttgtagaac tcagaagatg cagcatccat agcaagttta acttcttcgc caggtttgaa 2968261 gccggctttt tcgattgctt caacgattgt ttgaagcgct tcttcgttag aaccaaggtt 2968321 tggagcgaat ccgccttcgt cacctacagc agtgtttaag ccttttgcgc ttaatactga 2968381 tttcaggctg tggaagattt gagcgcccat gcgaagtgct tcacggaagt taggagcacc 2968441 tacaggcatg atcatgaatt cttgaatatc cacgttgtta tcagcatgct ctccgccgtt 2968501 tacgatgttc atcatcggta caggaagcgt ttttgagttg aatcctccaa ggtattggta 2968561 aagaggaatc tgtaagaaat cagcagcagc acgcgcacaa gccatagata cgccaaggat 2968621 tgcgttcgca ccaagtttgc ctttgttttc agtaccgtca agctcgatta aaagctgatc 2968681 gattgcgttt tgttcagtta catcaaagcc aagaagctct ggagcaatga tttcgtttac 2968741 gttgttaaca gctgttaaca cgccttttcc aaggtaacgg tctttgtcgc cgtcacgaag 2968801 ctcaaccgct tcgtattcac ctgtagaagc tccgcttggc actaatgcgc ggccgaaagc 2968861 tcctgtttct gtatatactt caacttcaac tgttgggttg ccgcgggagt ctaatacttc 2968921 gcgtgcataa acatcaacaa tgtatggcat gagttttgtc tctccttttg attttcaaat 2968981 tatttttgaa ttaaagatgt tcctgtcatt tctttcggtt tttcaacacc aagaaggtct 2969041 aataacgttg gtgcaaggtc gcctaggatt ccgccttcac gcagcgtaat gccttctttc 2969101 gttacaatca cagggactgg gtttgttgta tgcgcagtgt gcggttcgcc tgattctgta 2969161 atcagaatgt cagcattacc gtgatcagcg gtaatgatag cgtgtccgcc tttagcaagg 2969221 atcgcgtcaa cgacttcgcc caagcattcg tccactgctt caattgcttt aattgttggt 2969281 tcaaccattc cggagtggcc gaccatatca gggtttgcga agttaagaat gatcgcgtca 2969341 tgcttgtcag cttcaatttc tttgacaagc gcgtctttca cttcatacgc actcatctca 2969401 ggcttcaagt catacgttgc aactttaggc gagttgatga gaatacgctc ttcacccggg 2969461 aattcagctt cacggccgcc gctcataaag aacgtgacgt gcggatactt ttcagtttct 2969521 gcaattcgaa gctgttttaa cccgtgctga gataatactt ctccgactgt gttatcaaga 2969581 tttatcggtt taaacgctac atagccgtca actgtttcac tgaagtgagt caggcagacg 2969641 aaatacaggt tctttggata attctcgccg cggtcgaagt cacggaagtc tttgtttgtg 2969701 aacgtgttgg aaatctggat ggcgcggtcc ggtctgaaat tatagaaaat cacagaatcg 2969761 ccgtcttgga ttttcgcaac aggctcaccg ttttcttttg tgatgacaga tggaatcacg 2969821 aattcatcgt agataccatt tgcatatgaa tcatcaacaa catccagggc gctgcggtaa 2969881 gatgggcctt cgccgtacgc cattgcgcgg tacgcttttt ctacacggtc ccagcgtttg 2969941 tcgcggtcca tagagtagta acgtccggaa atgctggcga tttcacctac accgatttcc 2970001 ttgatttgat cgttcaactg gttgatgtac gttttcgctg tctgcggacc tacatcacgg 2970061 ccgtcaagga agccatggat ataaaccttt gtcagccctt cttttttcgc aagctttaac 2970121 agtgcgaata aatgattgat atggctgtgc acgcctccgt cagataaaag accgaacagg 2970181 tgcaaggctt tgttgttttc tttcgcgttg ctgatcgcgt caaggaatgt ttgattgcgt 2970241 tcgaactctc cttcacgaat ggcaacattt acgcgtgtta agctttggta cacaatacgt 2970301 cccgcaccga tatttaagtg acctacttcg gagttcccca tttgcccttc aggaagacct 2970361 acagcctcgc ctgaagcagt caaagtttga tgaggatact ggttccaata gcggtcaaaa 2970421 ttcggttttt tcgctaaagc gactgcgttc cctactgttt cgttacgtaa tccgaaccca 2970481 tcaagaatga tgagtgcagc tggtttttta ctcatattga ccttcctcca ataattgaac 2970541 gaatgactgt ggctcaaggc tcgcgccgcc gaccaaagca ccgtcaatat cggactctgc 2970601 catatattct ttaatgtttg caggctttac gcttccgcca tattggatgc gaagcttgtc 2970661 tgcagcttct tggctgaagc tttcagcgac ggttttacgg atatgcgcac acacgtcatt 2970721 cgcatctttc gctgtagaag atttgcctgt tccgattgcc cagattggct catacgcaat 2970781 aacagaagca gcaacttgtt cttcagaaag accagcaagg ccttttttca cttggtcagc 2970841 aacaagatca tttgttttgc cggcttcacg ctcttcaagc gtttcaccta cacagatgat 2970901 cggcacaatg ccgtgtttga aagctgcgtg tgcttttttg ttaactgttt catcagtttc 2970961 agcgaacatt tcacggcgct cagagtggcc gatgacgcag tagtcaacgc caaggtcttt 2971021 cagagcaacc gggctgattt cgcctgtgaa cgcgccgctt tcttcgaagt gcatgttttg 2971081 agcgccgact tttaggtcag tgcctttcac agcagaagca agcttttcta agaaaagcgc 2971141 tggcgcgcaa acaacagctt cagctttgtc tgctgctgga atggaagatt tcacttcttc 2971201 aacgaagctg acagcttcgc cgagtgtttt gttcattttc cagttaccgg cgataattgg 2971261 ttttctcatc tgttccactt ccttatagca gttttgagat tatttatcgt tcagtgcagc 2971321 tacccctgga agctctttgc cttccataaa ctcaagggat gcgccgccgc ctgttgagat 2971381 gtggctcatt ttgtcagcaa ggccgaattt ttcaaccgct gccgcagagt ctcctccgcc 2971441 gatgacagag tatgtatctt tcgcctctgc caatgcttcc gcaaccgctt ttgttccttg 2971501 agcgaacaag tcgatttcga atacgcccat tggtccgttc cacacgacaa gtttgctgtt 2971561 tttgatgacg tcagcatacg tttcgcgtgt tttcgtacca atgtcgattg cttctaaatc 2971621 actagggatt tcagagatcg gcacaatttt cacgtttgca tcgttagaga aatcatctgc 2971681 aacgagtaca tcttcaggca tgtagaagtt aacgcctttt tctttagcgc ggtccataaa 2971741 tgatttcgca agctcgattt tatcctcttc aagaagagat ttcccgactt catagccaag 2971801 cgcttttacg aaagtataag caagacctcc gccgatgatc aggttgtcta ctttatcaag 2971861 aagactttcg attacaccga ttttgtcttt tactttcgct ccgccgatga tcgctgtgaa 2971921 cgggcggtca ggattggaaa ccgcttttcc aagtacatca agctcttttt ccattaagaa 2971981 acctgcaact gctggcagat gctcggcaat tccagctgta gatgcgtgag cacggtgggc 2972041 agcaccgaat gcgtcattta catatacatc tgcaagctca gcaaatgctt ttgcaagctc 2972101 aggatcattt ttctcttcac caggatagaa acgtacgttt tccaatacaa gaacgtctcc 2972161 gtccttcatc tcagaaattt gtgcttttac agcatcgccg tatgcttcat ccgctttttt 2972221 cacttctttg ccaagcagtt cgccgagacg tgcagcgaca ggagttaaac gaagctcctc 2972281 aaccacttcg cctttcgggc ggcctaagtg gctcgcaaga aggacttttg cgccttggtc 2972341 tgcaaggtgt ttgattgttg gaagcgcagc acggatacgt gtatcgtctg ttacttcccc 2972401 gtctttcatt ggaacgttaa agtcaacgcg gcagaataca actttgcctt ttacgtcgat 2972461 gtctttgaga gtttttttat tcatgcctag gagatcctcc ttcaaaatgg tttgcataca 2972521 gcacgaaaaa cgtgaaaccg tctgttcaag cgataactcc gctagggcag atcgcagtct 2972581 ttttcggcac agggcagttc gtctaaaagc cagggcagcg gccttaggcg aaagcgccgg 2972641 caaagctgct taaaacgcgg tcgtttctct atcacagagc gttttctgaa agccggtctt 2972701 catggaaaaa gggaaaggga gtccgtcccc ttcccttgtc cgctttcatt atagcgcttc 2972761 tattcgaaag aaccaagtca ggtccttttt cagctataaa ttaaagacct ttttttgcga 2972821 tgtaagctgc aaggtcaaca acgcggttag agtagccgct ttcgttatcg taccaagaga 2972881 ttacttttac catgctgcct tccataacca ttgtagaaag agcatcgatt gtagaagagt 2972941 ttttgtttcc gttgtagtcg ccagaaacta atggctcttc gctgtagcca aggattcctt 2973001 taaggtcgcc ttcagccgct tctttaagag ctgcgtttac ttcttcagct gttacttctt 2973061 ggttcagttc agcaaccaag tcaactagag aaacgtttgg agttggaaca cgcattgctc 2973121 caccgttcag tttgcctttt agttcaggaa gaactagaga aactgcttta gcagcaccag 2973181 ttgatgttgg gatgatgttt tcagctgctg cacgcgcacg acggtagtct ttgtgcggaa 2973241 gatcaaggat ttgctgatcg tttgtgtaag agtgaacagt tgtcatcata ccgcgtttga 2973301 tgccgaattt atcgttaagt acttttgcaa acggcgcaag gcagtttgtt gtgcaagatg 2973361 cgttagagat aacatcgtgg ttagccgcat cgtatttatc ttcgttaaca cccataacga 2973421 ttgtgatatc ttcttcgtta gcaggagcag agatgattac ttttttcgcg ccagcttcta 2973481 agtgtttcgc agcgtctgcg cgttttgtga agaaaccagt agattcaact acgatttcaa 2973541 cgccttgttt gccccagcta agtttagcag gatcgcgttc tgcagaaact tcaattgttt 2973601 tgccgttaac aacaaggttg ttaccgtcaa ctgaaacttc agcgtctaat tttccgtgta 2973661 cagaatcata ttgtaaaagg tgagccagca tgttagcatc tgttaaatcg ttaaccgcta 2973721 ctacctcaac ttcaggattg tttaatgctg cgcggaatac gttacgtcca atacgaccaa 2973781 aaccgttaat accgactttt actgccatga ttgtttcctc ctttaaataa gtgagagata 2973841 tttatattga gggattattc atcccttaat aacttctttg cggctccttc gtctgtgacg 2973901 agaaccgtgt tgcgtggctt tttaaagtaa gcctcgatcg cttcggcttt tgatgatccg 2973961 cccgctaccg caataatatc ggggatggcg tctatgtcat ccagctgcat tccgacagaa 2974021 tgcactttgt gaaccacttc gccgtccgcg ttaaaatagt agccgaacgc ttccgtcacc 2974081 gcgtcgttat catctatttt ctttaaatct tctaaaggcg tgtttctgcg ctgagccata 2974141 gttttagctt cgccgattcc gtgaaccagc atactcgctg atttaatggt gttcagcacc 2974201 tctttgacag aaggctcttc aataatagat gaataggcgc cttgtgacag ctgtcccgga 2974261 acaaacaaaa gccggtaagt gcctgaagcc ttctccgcca tatgcgcgca tatggtgttc 2974321 gcctggtttt tcacgtcttc gcctaaaccg cctcttgcag gcacaaacaa aagctcgcgg 2974381 tttttagaat ccggcgtcat catttcggcg acagcttcaa ttgtcgtacc gccagttaca 2974441 gcgacgatat ttttgcctga aaatcttttt ttcatacatg cgacagccgc tcttcccatt 2974501 tcttttttga cccatgggga ttgatcgctg tctccggata cgataatggc atcctttaga 2974561 tttaaacgtt cttttaatgt cttttccaaa agagtcaaac ctaaaacatc tttcatcgta 2974621 tcttccaaaa cagaaagcag ttcatagccc tcttctgtca atgtcatgcc gtttgtctta 2974681 atatcgacca ggttctgttc ctttaaaaac tgaacctcgc ccctcagcac acgctcgctg 2974741 attccgagac tggcagacag gcttcttcgc ccgatgggtt ctgtcagcct gatatactgc 2974801 aagatttcaa acctcttttg cataacgagc agaagatcag gcaataattt tttttgagct 2974861 tgtattaact ggttcatgac tcaaacgttc cttccttttt tgctggacat tatatgtccc 2974921 gctatgacaa aaaacgtccc gtcatagcca aaaaaaatca tttctgcttt ctttaattat 2974981 tttaacaggg tggaattgtt tattcaactg ttaagagcca attcatcgac aatattcgca 2975041 gagttttcat gccgcgtcgt tttatccagc aatattttat cctatatatc tttatcttat 2975101 acagaaagcg ccaaatggtg catcccaata taaacagccc ttcccgtaga aagggctgtt 2975161 tcattaaagc gttttcattt tatccaaagc ttttcaattt cctcgagcga tttgttcttc 2975221 gtttctggac agatcgtaac gacaaacagg aaacaaagga tgttaatcac cgcaaagatc 2975281 caaaatgtat aggcgagccc gaaagaatcg atcatcattg gcacaaactg tccgatcgcc 2975341 cagtttgctc cccataaaaa gatggtcgca atgcccgcgg cccgcgcacg cagatggttc 2975401 gggaagattt cagaaatcat aatccatgtg atcggtccga ccgagacaca gaaagcagcg 2975461 acaaaaccta atataaggac gatcatcatg atcccgcttg ttaactcaaa ataaaacgac 2975521 gtcccgatta aaatcataaa aatagccata aaagcagaac cgatggacat cagttttttt 2975581 cgtccgactt tatcaatcag caacaccgca ataacggtaa aaataacttc tacaaccccg 2975641 acgatacaag tcgtcacaaa tccggcgttt tgcccgaatc ccatcatttt aaagatttcc 2975701 ggcccgtagt aagtaatcgc gttcatgccg atgacttggt taaacagcgc cagcaggatt 2975761 ccaatgacaa gcgcctttct gagacccggc ttaaacagct gggagagcga ccccatttgt 2975821 tctattttta aagagttctc aatgttcttt aattcttctt ttgcaacagt ttctccatta 2975881 atacgtgtca ggatctttaa agcttcattt gttttgcccg ctttcgccag ccatctcgga 2975941 ctttccggga cgacgagcag gacaaggaaa aaaatgacgg atggcaccat tccataagca 2976001 agcatccatc tccagccggt gtgcacgccc cattcgtatg ttccggaccg ctgcacagct 2976061 agattaataa agtatgttgc ggaaataccc agtatcgtaa agagctgata taacgaagat 2976121 aaacttccgc gtatagcggg cggtgccgct tctgtaatat acgtaacaga gagcgatgag 2976181 cccatcccga ttcccagccc cccgataatc cttgcaatga ttaaggtgga cacgtcttga 2976241 gaaagcgctg aaacgattgc tgatatcgca aataacaaag cggctgtcat taaaattttt 2976301 ctccggccga atctgtcact taaaaatccg gatatcccga cgcccacaac tcctccaatc 2976361 ataatgcttg aaatgacaag tccctccata aacggactca ggctgtataa atctttcaga 2976421 aaaccgatgg cgccagaaat cactgccgtg tcatagccat acaataagcc gccaagcccc 2976481 gccgcacatg agatcaaaat gacaaatccc attgaatggc ttcttgttac aggaacattt 2976541 ggttctaatt gagttggagt attcttcatt tccctgccct cccgaatgtt gagtaaagcg 2976601 ttttcattta aaccttcaat tgtacgtact tatattaaaa tttaacgaaa attacattta 2976661 attagtacgt acaaatatag aataatcttg tttgcatttt ctgtcaatgt tttcttacaa 2976721 agaacgctgt gatatactga aatttgtccg tatacatttt ggaggaatgg atatgttacc 2976781 aaaatacgcg caagtaaaag aagaaatcag ttcttggatt aatcaaggca aaatactgcc 2976841 cgatcaaaaa atccctaccg aaaacgaatt aatgcagcaa ttcggcgtca gccggcatac 2976901 catccgcaaa gcgatcggag acctcgtatc acaaggtctg ctgtacagcg tgcaaggcgg 2976961 aggcaccttt gtcgcttcac gctctgctaa gtcagcgctg cattccaata aaacgatcgg 2977021 tgttttgaca acttacatat cagactatat tttcccgagc atcatcagag gaatcgagtc 2977081 ctatttaagc gagcaggggt attctatgct tttgacaagc acaaacaaca acccggacaa 2977141 tgaaagaaga ggcttagaaa acctgctgtc ccagcatatt gacggactca tcgtagaacc 2977201 gacaaaaagc gcccttcaaa ccccaaacat cggctattat ctgaacttgg agaaaaacgg 2977261 cattcctttt gcgatgatta acgcgtcata tgccgagctt gccgcgccaa gttttacctt 2977321 ggatgatgtg aaaggcggga tgatggcggc ggagcatttg ctttctctcg gccacacgca 2977381 tatgatgggt atttttaaag ctgatgacac acaaggcgtg aaacggatga acggatttat 2977441 acaggcgcac cgggagcgtg agttgtttcc ttctccggat atgatcgtga catttacaac 2977501 ggaagaaaaa gaatcaaaac ttctggagaa agtaaaagcc acactggaga aaaacagcaa 2977561 gcacatgccg acagccattc tttgttataa cgatgaaatt gcgctgaagg tgattgatat 2977621 gctgagggag atggatctta aagtgccgga ggatatgtct attgtcgggt acgatgattc 2977681 acatttcgcc caaatctcag aagtgaaact aacctctgtc aaacatccga aatcagtgct 2977741 tggaaaagca gccgccaaat atgtcattga ctgcttagag cataaaaagc cgaagcaaga 2977801 ggatgtcata tttgagcctg agttgatcat tcgccagtcc gcacgaaaac tgaatgaata 2977861 aaaaaagcaa tgtatgggtc tccccgctac attgcttttt ttatagctgt tatctgtttt 2977921 tccaaacgtc agcgatgatt tcaaacgaac gcattctgtc tgcgtgttca aaggtttctg 2977981 agttaaccat aatttcgtca gcctgtgtcg ttttgacgaa atcttcaagc ttcgccttca 2978041 cttcttccgg acctccgaca atcgtggagc tcagctgctc attgaccatc gctttttcat 2978101 acgggctcca gatttggtcc atatcctcaa caggcggttt aagctggtta ggcgtaccgc 2978161 ggacaagatc aagaaacctt tgataatggg aagtcgcaag gtgctgcgct ttctcgtttg 2978221 tatctgccgc gataatggtg acaccgacca tcgcatacgg ttcgtcgagc acgtctgacg 2978281 gcgtgaagga attgcggtac agctccaaag cgggaaccgt attcgccggt gagaaatggg 2978341 ccgcgaacgc aaacggaaga ccaagttcgc cagccagacg ggcgctgaag ccgcttgagc 2978401 ccagcagcca aatcggcaca tctatgccct ctccgggaat ggcgcgaact tgattgcgca 2978461 catttcctga cggtttaaaa taattgcgca gttcctctaa ttgttctgga aaatcctccc 2978521 cgctgttgat gtttctgcgg agcgctctgg ctgtcaattg gtctgttccc ggcgcacgtc 2978581 caagccccag atcaatccgc ccgggataca gtgtttccag tgtgccgaat tgttcagcaa 2978641 tgactaatga agagtggttg gggagcataa tgccgccgga accgacgcgg attttcttcg 2978701 tgcctccggc aatatggcca atcaaaactg cggtggcaga gcttgcaaca ccttctatat 2978761 tatgatgttc agcaagccag taacggtgat agccccattc ctctgcccgg cgcgccaagt 2978821 ccatgctgtt tcggaatgat tctgcaatcg ttcctccctg aacaaccgga gataaattca 2978881 agacagaaag caaggtatct ttgcgttggt tgttagacat attgttctcc tttgcaaatg 2978941 tgttatcagt aaacagccca aagctgtcag gtcatgattg aaagaacttc tatcacacca 2979001 taacacaact gcattcagga ataaaagaat ttgattcgat gaaattcgaa caatataaaa 2979061 cgaacggttt ggaacattat tctgctccaa acaactcctt agccatctca ataaagagct 2979121 tagccgccag agaagcctcc tttagcgacg gaacagcaag ctgcacatca cggtatacct 2979181 gcgggtccaa ttccctggtc accacatgct ctggcagcgg catccccgac atggacattt 2979241 ctgataaaat ggccaggccc aggccttctc tgatcatact gatcgaggtg ttgatgttat 2979301 agaccgtgaa agctgggtgc agcgtagcac ccgcctgcct gaacatatcg ataaatggtg 2979361 attcatagcc gccgtcacag acgatcatcg gttcatggtc aagatctttc agcgtaatgg 2979421 ctgaatgact ggcaagcggg tgatcgtccc tgagcacgac agccattttg tcttttttca 2979481 aatgaatgta ctccatctcc tctgttggat acagaagaat cccaacatct atcatccgcg 2979541 tatgaagcca ctccttgact tcatttacag ttccctcgtg cagcacgagc tcaagtttcg 2979601 gatatttttg tttaaattca ctgatcagct tcggcataaa ataagccgag gcagttgaga 2979661 atgtgccgat atggatcgtt cccagttcaa gccctttttc cgctgctgct acctgctcaa 2979721 ctttttcaat gccttttaag acttctctga tgtgtactaa gatctgtttt cccgtatccg 2979781 tcagcatcag gccattgcgg cggtcacgaa tgatcagctt tacatcaagc tcagcttcga 2979841 tcgcagaaat cgcatggctg acagccggct gtgtcatgtt cagcgcctga cccgcttttg 2979901 taaagcttcc cgtttcagct attttcacaa aaacctttaa ttgagtaatg gtcataacaa 2979961 tttacttatg ctccttataa aaaagattca ttttatttat cttatgttct accgtatcat 2980021 atgatggaaa agttctacaa ggagtgaatg aacaatgaag cagctcccaa aaacgcggac 2980081 agctctcctg ctcgcatttc tcgtcatcat gtggggcgtc aattggccgc tgtccaaagc 2980141 cgcgctcgcc tattctccgc cattattgtt cgcgggcatc cgaacgctga tcggcgggct 2980201 tttattagtc atagtcgcac tgccgcgtat tcataaatta cgcttaaaag aaacgtggcc 2980261 gatttatctt gtttctgctc ttttaaatat tacattattc tacggcctgc aaacgatcgg 2980321 gctgaattat cttccggccg gcctgttttc tgcaatcgtc ttcttccagc ctgttctgat 2980381 gggtgtattt tcttggctgt ggctcggcga atccatgttt gtaatgaaag tgattggcct 2980441 catcctcggt tttgcgggag tagccgtcat tagtgctgcg ggctttggcg ggcatatttc 2980501 tgtcattggg gttctgctgg ctctcggctc cgcagtcagc tgggcgctcg ggacagtata 2980561 tatgaaaaaa acaggcagcc gcgtcgattc catctggatg gtcgctctgc agctgacgat 2980621 cggaagcgtg tttctgctta tctccggctt ttggacagaa agcttttcgg cgatccaatg 2980681 gacagctccg tttattacga gcctgctgtt catctccgta ttcgttatcg cactcggctg 2980741 gcttgtcttt tttacgcttg tcggttcagg agaagcaagc aaggtcgcat cttatacttt 2980801 tttgattccg ctcatatcaa tcgtggccag ctccattttc ctgcatgaac cgctcaccct 2980861 tagcctcttg gcagggctgc tgctgattgt cacgagcatc tgtctcgtga atacaaaatc 2980921 aaaagcgcag aaagctgcgg cgattggtat aaacgagaaa gctgcacaat aataaaaacc 2980981 ctcttgccgg atgcggcaag agggtttctt atttactgat gcttgcgtcc tttgaccaaa 2981041 tatgcaactg taatcaaaag gtagatcgcc gcagtaatgc cggtaatgac aattgatgtt 2981101 gtcatgatga ccccgatcag aatggcgagt aatgccacaa tcgcaaacca tgtcgtgtac 2981161 gggaaccatt ttacataata ggccggtgtt tccgtttgct gttttctcga ttttaaatga 2981221 gcgaatccga tgatcagcca aatgaataaa acggtatatc ccaatgatcc cattaaataa 2981281 ttaaatgttt ggcttcctgc gaacagagaa atcaatacgc caatatagag agaagaagtg 2981341 cacatcagaa tcgcaaacat cggtacgttt ttcgatgaaa gcttcgagaa gacctttgga 2981401 agccttccgt cacttgcctg tgtatacaaa atgcgtgatg atccgtataa acctgaattc 2981461 atagaagaaa tgatcgccag caggatgact gcattcatga tatgatccgc gcccggaatg 2981521 cctaccattt taaagaccat cacgaaagga ctttccggaa cggaattgac ttggttccat 2981581 ggaatcaggc tgacgatgat gaaaaacggc agcaggtaaa acgcgacaat ccgtgtcagt 2981641 gtgctgcgga cagctttcgg gacaaccttt tccggatttt ttgtctctgc aagcgttaca 2981701 ccgataattt ctgtaccgcc gtaagagtag atgacgacaa gcatcgccgt gatcagccct 2981761 gtgccgccgt gcgggaaaaa tccgccgtgg tctgtcaggt tggaaaatcc ggatgctgta 2981821 tgatcaccga atgatacaaa taagagcagc aatcccagaa taataaagat aataataacg 2981881 gtaatcttga tcattgccag ccaatattca gtttcggcga agattttaac agaaagcaag 2981941 tttacaatcg tgacgataag agaaattcct aatgccaaca cccagatcgg gcagcccggc 2982001 agccaatatt gaatgaaaat cgcagctaca acagcttcag ccgcaatgtt aagcacccac 2982061 attttccagt agatccagtc caaaaagtaa gcagcgtaat ttcccaatac ctgctggaca 2982121 agatcacgga aggttctggc gttacggttt cgaacagcca tttccgccag cccctgcata 2982181 ataaacagca aaataatccc gccgagcagg tatgcgataa tgacagatgg ccctgccaca 2982241 tcgatcgctg agctgctccc cttaaataaa cctgcgccga ttgctccgcc cagcgccatc 2982301 atcataatat ggcgggacgt catcgtgcgt tttaacgttt gattgtcgtt tttcatcctc 2982361 ttctacctct ccttctcgtt ttcaaaaaca aaaaagcccg ccgtctccta cctaatctaa 2982421 tagataaaga gacgacgagc cttcggctga ccgcggtacc actcttgttg attcttcatg 2982481 aagaatcctg cttttgacct gtaacgaagg ttagccgtta aaacataggg aatattcaat 2982541 ctattccgtt ccgtcttacc actcccgggc gagttcaaag aagaatcagg ctgcgtcgca 2982601 ccaccccgca gctctctgtt ctgatcactt tcttttactg ctcccaatct atgtgtttta 2982661 gttttctgaa aaactcaaat tttatgatct gaatatatta acataatata cgtgcttctc 2982721 ttttaactgt caataacttc agagaaaaaa gaaactgtta ttttgtccct tttcgaatgg 2982781 ctttccaaaa ggattctgac tcgtttccta atgcgtaaac tgaaacacct gctattttat 2982841 attgctttgc cagatggctt ttcgtttgaa cggttttttc gttttcatac cacacgacat 2982901 gtttatgctt ctttttgtca acataagaaa acgtcatcga gcctgatttt ttgttgaatg 2982961 ccggctttgc tttttgtttt ttgatgaggg atttgagctc attccattcc cttattgtgc 2983021 tggtacttcc gtcttttaca tcccagtcat agccgtacgc agggattccc atgatgactt 2983081 tattggcttt gatctttttg actgaaaact gcagagagct tttgatccag tttgtgcttg 2983141 ccactgaccc cggctcaccc caaatgccgt gttcatcgta ggtcatgact tgtacgaagt 2983201 cggcatattt gccgattttc gcataatcat acggccagct ccagtcatca tttttatcat 2983261 cggcgctttt ggccggaacg gataccattg ttttaatatg tttcttattc aaagcctgtg 2983321 agacatattg aatgaagttc gagtatgcag cgcggtcttc tggatttact gcttcaaaat 2983381 cgatattgat tccgtaatat gagtgctttt tggccagtgt aattaactga tctgtgaatc 2983441 gttttttcgc tgttttattg ctcatgaccc gactcgctaa atctccgtca aaatcataaa 2983501 tggcatcatt atagtttgaa atgacagccc atgtcttgat ttttttcttt ttcgcatatg 2983561 tcagctgctt agttggggca tcgccaatga tttgtccgtt tttttcaaac gcaaatgtat 2983621 cggttgcgat ggcattcatg tatgtatgat atttcgtaag agaattgtat gaagccgtat 2983681 ccccagtcgt gtagcctact gtcataccgg ctgccttcgc ttctcctttt gtatacataa 2983741 acagaacaat cgcaatcgcc agtgaaaccg ctatgatcag ccattttttc atcgcatttc 2983801 ctcctgtatc aagtcatact cttctcatcg gccaaaaaat tggaagttga agttttttca 2983861 agcaaaaagc ccggcatatg cctgccgggc ttcctgagtt cagcggtcag agacgagaat 2983921 atatgctgcc tttactggtc catgcacccc cacaactaaa tccatttcaa tgtcggctga 2983981 gttactcggt ccggtaatgt agttgataca tgaaggaaca gtgacaccgt tcgcaatgtt 2984041 ttggcggatg atatcactgg cttgtgtcat tctcggtaca atgcttgatt tcggcacgat 2984101 cgcaatataa gtcgttggca aaaggctgac agagcggccg atgtcttttg aggagaagag 2984161 gacaaccgtc cccgactcag ccaatgtaat ttcgctgaat gtaatcccta cattggcttg 2984221 ctccgctttt ttaatatttt cctcgccttt gtcagcatcc cactcccaga ccggcgttcc 2984281 ttcactcggc cagtccttgg tgagcaggct tttcagtccg tattcttcaa agcgggggtc 2984341 cttcggaatg atgacagggc ctccagaaaa gcggctgact tgctcgcgca gggcatcgta 2984401 aaggccggtt gaatccgttt caatcagctc tgtatggatt ttgacacaat ggtttttgag 2984461 cactgtgact aagtcatccg ctgaataacc ttcaagtgtt ttatattgcg gctgatgcgc 2984521 ccattcaggg actgccacgc ctcctgttct tcgttcacgg cccaggctgg atgcgattcg 2984581 gtttaaaaag ctctcttgat tctgaatggt tcccttcgtc atcactgctc ctccttcgtg 2984641 cgttcacttg tttctctgtc cgcaaaccag tctctgaatc tcgatttatg cggtgccggg 2984701 aagtcgcgaa tctgggtcca atttttaagc gggccgggcc ctttcgaaat tttttcgtcc 2984761 tctgtaaaag gcgtcatggc ggccggcgcc cattttgagc ccattttgta aagcgataag 2984821 gaggatgcgc caagtccgaa tgctttcatt gcaagctttt cactgatcgg cgccctgcct 2984881 tctttttcga cgatattctg acgatgcttg agtagcagct catgaagcgg gattttgacc 2984941 gggcaggctt ctgaacaagc agcgcacagt gaagatgcgt acggcagctc cttataatcg 2985001 tcataaccgc cgagcaacgg tgataaaaca gctccgatcg gccccgagta gattgagccg 2985061 tatgaatgtc cgccgacatg gcggtacaca ggacagacat tgatacaggc ggcacagcgg 2985121 atacattgca gcacagactg gaattccgtt ccaaggatat tggatcgtcc attatcaacg 2985181 atgacaagat ggaattcttc cggaccgtcc acttcacctt ccagcttcgg acccgtcaaa 2985241 gctgtaatat agcttgtcag ccgctgtccg acagcacttc tagtcagcat gctgactagc 2985301 acttcaaatt cagaaaatga cgggacaatc cgctccattc ccatgacggt aatttgtgtt 2985361 ttcggcaagg tgctcacaag ccgtccattt ccttcattgg tcacaaggct gacggaaccc 2985421 gtgtcagcga tggcgaagtt acagccggta atgccgatat ccgcttccag aaactttttc 2985481 cggagaatgg cgcgcgcatg catcaccagc tcttccggtt tttctgtatg ttgatagtcc 2985541 agtctttctt taaacacatc gcgtatctgc tctttatttt tatgaagagc gggcgctacg 2985601 atatgtgacg gcggatcgtg atcatcaatc tgcaaaatat actcgccgag atcggtttct 2985661 acgacttcac agccttcctt ctccagcacc tcattcagat tgatttcctc tgtgaccatt 2985721 gatttagatt tcacaatttt cttcccgttc ttcttttgaa tgacatcccg aatataggaa 2985781 gacgcctctt ccgctgtttt cgcgaaatag acatgtccgc ctcttttcgc cacattttcg 2985841 gcaagctgtc cgagatagaa atcaaggttt tcaaggacat gctgcctgat ttcctctgat 2985901 aatgagcgcc actcctccca gtttcccagt tcttctgctg cctctaggcg ccgcgtccgc 2985961 agacgctcct gtgcacctga aacagcgcct ctcataaatt cattatcaat cccctgtgat 2986021 acccgctctt taaaagcgtc agtaccgatt ttcatcgcca tgatcctttc cccctctgaa 2986081 tccagtttta tctgctgttg agcacttcgg cgatgtgcat cactttgaca ttcttatctt 2986141 ttcggccaag ccgtcccccg atattcatca aacagccgca gtcagcaccg atcagcacct 2986201 ctgctcccgt ttcctccaca cattcgactt tttcatcgac catctgctca gaaatctgcg 2986261 ccatcttgac tgagaacgtt cctccgaatc cgcagcagtt atgtttgccc ggaagctctg 2986321 taaactgcag gcccttcaca tggctcaaca gcttcatcgg ctccttccga acacccagca 2986381 gcctagtcat atggcacgac gtatgtaagg tcgcttttgt atgaagggtc gcgccgacat 2986441 cctctacccc aaggacgttc acaataaaat ctgtcagttc atacgtttta tccgccagct 2986501 ttttcgcttt atcggcccat ttcggatcat cctgaaacag gtgcggatac tcccggaaca 2986561 tcgttgtgca ggaacccgaa ggactgacaa catattcgga atcctgaaac gtttcgatca 2986621 tccgtttcat tgcttttttg gcgtcatgta catagccgct gttgtaagcc ggctgtccgc 2986681 agcaaatctg cccttctgga aaatcaacct cgcacccaag ccgctccagc agctcaaccg 2986741 ttgcttttcc gacatttgtt tgaaacatat caacaagaca agtgacaaaa agtgagactt 2986801 tcatgatgaa cccctctctc atccccaata tatgatcagg tcatctgatg acctgagtta 2986861 aaataactat atgaatatcg tacactattc tgacaatgga aggaaagagt tttctaggga 2986921 tattttcatt tgtggcatat caaaaacact cccgatctcc caggagtgca gtatatggtt 2986981 agatccagcc cttttcctca gcgatgctgg cggcttctgt ccgatttttc gcattaagct 2987041 tttggatgat ttctgagata tagtttcgaa ctgtgccttg agataaatag agctccagcg 2987101 taatgtcttt tgttgtcttg cctaaagccg caagcctcag aatttcttgc tctctaacgg 2987161 ttagcggatt ttcgtctcgc atcatattaa acgtcagctc agggctgaag acacgttttc 2987221 cctttacaca ttttcgaatg gcatcggcca gatcgtcaat ttcaccgtct ttcagcagat 2987281 agccatgtgc accggccttt acggcgcgtt caaaatatcc ggggcgggca aaggtggtta 2987341 aaataatgac cttgctgacg cagccttttt tcattaattc ctctgccaca ttcagcccgc 2987401 ttcgaaccgg catttcaatg tccataatgc atacatccgg ctccagcttc aaaatagcat 2987461 gtagcgcctc ttccccgttt aatgcttgtc cgatgactgt catatcctct tctaaatcaa 2987521 gcaaagatcc caaagcgcct aaaagcattc gctggtcctc agcaataaac agacgaatca 2987581 ttcttttcgt cctccaatca ttctgctttt ttaataagcg gaatcgtcag tgccacaacc 2987641 gttccgttat ggtctgaaac cgttaatccc ccttcaatga gcatgagccg ttcttccatt 2987701 ccccacaggc cattcccaaa cattttctcc ttcggcgctc cctttccgtc atcccgtatt 2987761 acgatcctca ttttgtcagc aaattgagaa atggtgatgg cacagtgggt tgctttgctg 2987821 tgcttgataa tgttagtcac ggcttcccgc atacacatac tgataatatt ttgagtgacg 2987881 ggagatatca ctgaaaagtc gtcggctcct tcgtattgaa aggtaatgtt ccccgctctt 2987941 aatatgtgct gaatgtttac gagctcctct gttatcgtga ccgttctcat atcagaaacc 2988001 agctctcgaa cttgcttgag tgcggagcgt gaactggttt ccatttcttt tgcctcaagc 2988061 ttggtccgtt ctggatcaga tgcagccagc cgctgaatga gctggctttt taatgtaagc 2988121 agcgacaggg tgtggccaag agtatcgtga agatcacggg cgattcgaac acgttcctcc 2988181 cttttagaga gttcttttat ctgttcgttg gcttgtgcaa gcttagcttc aagctcaatc 2988241 ctccgaaaca tagaacgaat tccgaatgga gaaatgagca taatgacgag aaacgggaga 2988301 acagaaaaaa gctcccgaag cgagaccgaa ttcgcgataa attggtatag gcatggaaaa 2988361 agcagtataa agattaaagc gcagaacgca cggttaaaat tcgttttctc tttgtaataa 2988421 ccaacaaagt ttgccggaaa aaaacctaag tatatatagg tgatattgta aaacacacta 2988481 tacatcaaaa taaccgccat ttgcacgata agccaatatg taaacgaagc tttgcccacg 2988541 ctgcagaata actggcgata tgccgctaca aaaaggagca gcataccata tccgatcccc 2988601 tgtttgaccc ctgattcttt taataaagag aggaacggca taatcgtata caccagaaag 2988661 atataaggga aaaacccgaa ttccttcggg aaaatagata ttgccttttt catgtattac 2988721 accgcttctt gttttcttct tatatattta gatagtagca tgaagagcat catataagcg 2988781 attaatatca gaatattttt ccaagtcgga ctcccacccc ggacaagttc ccacgctccg 2988841 ctcccgaaat gataagacgg aagccactgg ccaatgctct gcatcatgtc aggcatgacc 2988901 tcaaacggca tccacatccc tccgcctaaa gccagcagca tataaagcac attactgatt 2988961 ccggccgctg tttctacttt tctcatgagg ccgattagtg tgcctaatgc taaaaaaggc 2989021 aatgcgccaa acaaaatcca cagtccgctc atcatccatt caaacggtga caaggcaata 2989081 tcattgatga ttgcgccgaa cagaaatatg acggtaattg ataaaacgtg aatgacactt 2989141 tggccgatca tctgagctga taaatagata tgatccggaa gaggcgtaag gcggataaag 2989201 gcggcccagc cttgtgaccg ttcttgtacc attcggatgc caagcgtcat gatagaggaa 2989261 cccatcacgc tgaagactgt catcgacatc aggtaatggg cttcccatgc acgttgatca 2989321 gggacgttgg tattcactac atttgtaaag aaataataaa aggcaatcgg catgatcaga 2989381 gaccaaagca caaagtactt gttcctaagc acccttttca tttcagcgat gctttgcttt 2989441 tgcagcacgt tcactcacat cgcctccctg ttgccgtcag ccagctggcg aaatgcctca 2989501 tcgagcgttg cttgctcaat tcgaatatcc cgtgcatgta tgttttcttg aaagatcagc 2989561 gccaacactt tgtctgtatt tgatgtctgg atgatggttc tctcatgctc gtggatcact 2989621 ctctcgactt ccgggtgaca agacagcctt tccaatgatt cacttgaatg aagcgtaaag 2989681 gaaacagact gtttttgaat tcttgagcgg atttgcattg gtgagccgtc tgcaacaagc 2989741 tgtccttcag taaaaaatag gattcgctgt gcggcatcat ctgcttcctg taaataatga 2989801 gttgaaaaaa taatcgtttt tccttggtcc gacagtccgt gaatggtctg ccagaatcgg 2989861 tgtcttgatg aagtgtccat gccgactgtc ggttcatcaa gtataagcag ctccgggttc 2989921 ccggcaagag ccaaagcaaa gctcaaacgg cgtttttgtc cgccggataa tttttctgct 2989981 cttgttttca aatcttcttt ggtgagtgct gttaacgaaa cgagttcttt catggacaat 2990041 ggattcggat aatagctccg gaagagttca aggatttcat ccaccttaag gcccggcatg 2990101 acacttactt cctgaagcat tacacctatt ttttcacgaa cctgttgatc atcgggaacc 2990161 cggttaaata gtttgatttc tccctcactc ggtttcagca atcctaatat catcgagacg 2990221 acggtcgtct tccctgcccc atttggcccg agaatggctg caatttctcc tttttcaata 2990281 ctgaagctga tgttgtttac agcggttttt cgctggaaat gttttgtcac gttgcttact 2990341 gttactgctt ctttcatcac atgagcacct cctgatcgtt tacattgatt gtaaaatgac 2990401 ggagaagacg atgttagtat ggggtgtcat gatgatggag tgacaaatgt catttttttc 2990461 tcaccccggt gtctaggcaa tcctcctcct gcatcttcca attcatccat cttttctatc 2990521 tcccatgtcc tctttctttt aaactgctgt gacattcata gaaagataca ctcttcaaac 2990581 catccgagtg ttatgataga aatattgaac tttatattac tttccggctg aaaggagcca 2990641 atcatgaacg aagcgatttt gtctagaaat catgtgaagg tgaaaggcag cggcaaagca 2990701 tctatcatgt tcgcacctgg ttttggatgc gatcaaagcg tgtggaatgc cgtggcacct 2990761 gcctttgaag aagatcatcg ggtgatttta tttgattacg tcggttcggg acattcagat 2990821 ttgcgcgcat atgacctgaa tcgttaccag acacttgacg gctatgccca ggatgttctt 2990881 gatgtttgtg aagctttaga tctgaaggaa accgtgtttg tgggtcactc cgtcggggcc 2990941 ttgattggga tgcttgcatc catccgccgc ccggagcttt tttcccatct ggtgatggtg 2991001 gggccttctc cttgctattt gaatgatccg cctgagtatt acggaggatt tgaagaggag 2991061 cagctccttg gcttgctgga gatgatggag aaaaattata tcggctgggc gactgtattt 2991121 gcggcaaccg ttctgaatca gccagatcgg cctgaaatta aggaagagct tgaaagccgt 2991181 ttttgttcta ctgatcctgt cattgcccgc caattcgcga aagcggcgtt tttttctgat 2991241 caccgagagg atctttcgaa ggtaacggtt ccctctctta ttctccaatg tgcagatgat 2991301 atcatcgcac ctgcaacagt aggtaagtat atgcatcagc atctgcctta tagcagtctg 2991361 aaacaaatgg aggctcgcgg acattgccct catatgagcc atccagatga gacgatacag 2991421 ctgatcggcg attatttaaa agcacacgtg tgatatagga acgaaaggga tagaggtgac 2991481 cctcttagat ggacaaacaa ttgaatgatg caccatgcgg tttcctcgct ttgtcagaag 2991541 aggggtcgat catagctgcc aaccgcaccc ttatcaagat tctggattat gaaccggagc 2991601 aggttatcgg ccagcacatg aatatgatgt tgaccattcc cgcgcagctt ttctgccagc 2991661 tttatttttt tccgcttttg aaattggagc atcacatcga agaaatatac atttccctga 2991721 aagcaagaga tggagaagaa attcccgtcc ttatcaatgc tattgcgaga cacgatagcg 2991781 gggcttctgt ctttgattgt gttctgattc caatgcgaaa gcgaaatgaa tatgaaaatg 2991841 agctgctgat agccagaaat gaggctcagg aagctttgct tgccaaacag aaagccaatg 2991901 cggagttaga aattgccttg gaaacgctga aagcaaaaca agaagaactt cttgagatca 2991961 ataaacaaaa tcaacaattt aaattaaaca ccaaaagaga gcttgaactc gccagaaaga 2992021 tccagaaaaa ctcgttgact gaaccgattg taaacgatca ggttcagatt gactcttatt 2992081 acaacgcatc gagtgaattg tcaggtgatc tttacggata ttatcaaatc gatgaacacc 2992141 gttacggcat tattatcctt gatgtgatgg ggcacggaat ttcatctgca ttgattacga 2992201 tgtctcttca tcctttgttc cagcgccaga tcacgcaagg tctcagcccc gttaaagtta 2992261 tgaaggaatt ggaccggcac cttcacagct tgtttcaaaa tgatgaggaa gcaagacatt 2992321 attgcactgc tatttatctc gagattgata tagcacggca aagaattgat tatgtcaacg 2992381 cagggcatcc gccggcactt tggcaggacg atagcggaac tcaacatctg cttcacgcga 2992441 cctcgcctcc gatcgggatg tttgaagact tagagtttca gtcaagcagc ctttcataca 2992501 cggaggacgg aagattgctt ctgtatacgg atggcgtgat ggatcctacg gcttcatgtt 2992561 atttatttga tttactaaag gatcatcctg attcgccaat cgctgacctg aaggagaaaa 2992621 tccttacatc actgcagcat caaaaggaag ctcatcataa gagtgatgac gaatgtttta 2992681 tattagttga tgtaaaataa aatgatccat gagacataac aatgatttgt tacatctcat 2992741 ggattttttt gtttcagcgt ttctttggaa tatgtcctga ctccgcatat tgaaacacct 2992801 gcaaggaagg cagcgggtgt ccattaaaat caaataaagc ttgattatct acagcacttc 2992861 ccccatacca cttcccggcg tcttcagggt cgtattcagc agcatagctg gacgcccacc 2992921 ctgacccgta tgtttcccat aacactttgt ttttctctat ctgtgtcttc ggcccgactg 2992981 gaatccacgc cggctcccag tagaaaacac caagtcctgc tttgcccgta ttcgccactg 2993041 cctccattac atctcttact gcagttgcct ggccttgaac agaaattgga tatggcaacg 2993101 tctgcccgct ttttggtgct gtatttccat gcccatcgcc atcctcagcg gtataggtgt 2993161 acgatgtctc cgccaccatg acttttttgc cgtacgtatt ggcaacagcc ttcagcacgg 2993221 aggtcaaatt ttgtaatgtg ccatgccaga aaggataata ggagctagca aacacatcat 2993281 aatccacttt gtttttgctg agtgtttctg caataaatga ataccttcca gccgtttcag 2993341 gattggtaaa atgcagggcg accaaaatat ttgaatttgt ctccctgacc gctcggcttc 2993401 cttcattaaa taattggcac atcttcgtcc aatcagtctc accggcaaat cctcctgttg 2993461 tttcatttcc gacctgaacc atgccgatgt caacgccttc cttgatcatc ttttgcaggc 2993521 tttgtttcgt atactcatag agctttgctt tttttgcttc aaagctgaga ttcgcccagg 2993581 ctttgggcac cttttgtttc gctggatcgg cccagaaatc agagtagtga aagtcggcca 2993641 gcaccttcat tccgttcgct gtcgctcttt ttccgatttc gatggctttt tgaacatcat 2993701 tgtttccccc gccatacccg ttgccatttg aatcatacgg gtgattccag atgcggacgc 2993761 gaacatagtt gaccccagcc tgttttaaag ttgtaaagat atcctggcgt tttccgtttg 2993821 tattgtaaaa ggtgacaccg ctgttttcca aagcaataac gctggataca tctgcccctt 2993881 tgataaaatc cttgttcatc ccctctactt ttttaacaaa aagatcctct gcccgaagct 2993941 ctgacacgtg cttctccttc tcaatggcag cggcatatcc tgttgaacta catgcactcc 2994001 acacgatggc agccgcaaag aacattttca ctttgctttt catgatttca tccccccaag 2994061 acttagcaag cgttttcatt ctatagaaaa aagaatccgc ccatatcgag cggagcatca 2994121 gcctaatgtg tgtttacgac aattctcact tcatactttt ccatcgtcag gtcgcctgac 2994181 aatatgtctc ctgtcattat gtccttcaca ctctgatcaa acgtgaccag ctgtttttct 2994241 tccgtgaaat tcatgacaaa aatataatca ttgtcctgat cctgcctcgc ttgtacggag 2994301 acgccttttc cgtgccgaac cggaaaaact ggagagagag acaggtctgt gatcagaccc 2994361 tcatagaaat cacgctgaaa ttgatcctcc aaacgcgcgc cgataaaata cgccttgccc 2994421 tgctgatact catggcttgt gaccgctggc gtgcgcgcat aaaaatcttc ttgatacacc 2994481 gcttccactg aagctgtctt tacatcaatc acggttgcat aatccttcat ttcatatatt 2994541 tggctgcggt agctgacagc gtttcgatcc ttcggataca gggtgtccgt ttcaagaggc 2994601 tcaactccaa atatagcttg aagatccgga tgccatccgc ctgtgtatgt taagtcatgc 2994661 tcattcacaa ccccgctgat atacgtcatg actaaggtgc cgccgtcagc cgtaaacgct 2994721 tttaaacggg aaacggtgtc ctcgctgatt aaatacagca tcgggacgat cagcagttta 2994781 tatggtgaaa agtcttgttc tttcgtgatg acgtcgacag ggatatcgtg ttcccagaat 2994841 gtgcggtaat gctgctgaag cgtttgcgga taacgttttg tcgccttcgc aaacccctga 2994901 gcatcctcga gcgcccaatg attttcccag tcatataaaa tcgcggtttg agccggcctc 2994961 ttcgttccga caacttcgga cagccgttcc aatgtctcgc ctaccttggc cacttcttga 2995021 aagacgcggt tcttcgggct attgtcatga tccacaaccg ctccgtgtaa tttttctgat 2995081 gacccccgtg atttgcggta ttggaaatag agaacgctgt ccgagccgtg ggcaatcatt 2995141 tgcatggatg acagcagatt catgcccggg cgctttgcct tgttgacgtt atgccaattg 2995201 accgcgcttg gcgtacactc cattaataag aagggctgct gcttcaagct tcggtacaga 2995261 tcattgataa agccgacctt catcgccaaa tcagctgtgc tttcccagtc attgtgccag 2995321 acaggataag cgtcccagct gatggcatcg acatgctttg caaatttgct gtagtcgagg 2995381 ccctgatacg ggatcaaatc cggtgtgtca gccataaaat tcgttgtgat agggatatca 2995441 ggcgtcaatt ctttcagcgg aatgatttca ttttcataaa acgaaatcgt ttgatcggtg 2995501 acgaaccggc gccaatctaa attcaggcca tgcaagccat tttcaccgat cggcgaaggg 2995561 ctttcaattt gtgaccagtc attgaacgta tggctccaaa aaggggtcca ccacgcatgg 2995621 ttcaatgtct tgaggctgtt gtcatatttc gatttcagcc actcccggaa agcatgctgg 2995681 cataaatcac agtggcaatc tcccccgtat tcgtttgaaa tgtgccacat taacagcgcc 2995741 gggtgatgtc cgtatcgttc tgctaataag cggttgatgt gccgtgtttt ttctcggtag 2995801 actttagatg tgaggcagtg gttgtgcctt ccgccgtgca gctgtttgac gcgggaggca 2995861 ttgacgcgca aaacttccgg ataggtttgc gacagccagg ccggacgggc tccgctcggc 2995921 gttgctaata tgacccggcc gcctatactg tgaatccgct caaaaatatc atccagccat 2995981 tcaaattgat atacgccctc ctccggctca agtgcgctcc atgcaaaaat gccgacagaa 2996041 aacgtattcg tatgagaaag cttcatcagt ttgatatcgt cagctaaaat atcgggccga 2996101 tccagccact gatcggggtt gtagtctccc ccatggagca taaattttgc ttttgttacg 2996161 tgcgtttttt caagctttga catcacattc tcctccttgt tctcttagcc cttcgttccg 2996221 cctgcggtta atccggacac aaaattcttt tgcagcataa taaagatgac ggcaaccggt 2996281 atgctgataa gcagggctcc ggccgcaaat gtcgtatagc tggcccccat gacatcattc 2996341 actaaattga atagaccgac gggcaatgta tatgattcag gcgttctcaa tatggttgag 2996401 gacagcacaa aatctccgag cggaccggta aagccgttca tggccacgac tgccgccatc 2996461 ggttttgata atggcagaat gatctggaag aagattctgg tgctgctggc tccgtcaatc 2996521 ttggcgcttt cgtctaaatc catcggaatg gaatccatgt accctttcat caaatacgta 2996581 ttcatcggga tcaggccgcc gatataaagc aagattagca gccagtggct attgatcatt 2996641 cccaagattt gcgccagcac aaacaaggca attaaagctg aaaactgagg aatcatctgc 2996701 agcaataaaa agagcgttaa agcgtatttc ctccctttaa accgaaagcg cgaaaacgca 2996761 taggccgtaa acgtcacaca gagcaaagac cctgccattg taaacaggct gatcttcata 2996821 gagttgacat accactgcac atattgaagg ctttccttgc ccgcaaataa ttccttgtaa 2996881 tgatcgaatg tcggatgctt cggaatgatg gatgtactga ttaagctgtt gccgggatta 2996941 aagcttgcgc ctgccgtcca aaggagagga taaacaatga tgaccgccat aaaggctagc 2997001 aacaagtaag agaaaaggag acggatatat cttctgactt tcatatctgc cagcatacct 2997061 tatgcctcct ctttaaaaga ctttgtctgt ctgaactgcc acaatgcgat ggagataaca 2997121 aatacagata ataaaatggt taaagccgca gcaagtgaat attggctgga ctgcattgtc 2997181 aatttataaa tccatgaaac gaggatatct gtcccgccgg ctgttgatcc ggttacagcc 2997241 ggacctccgc cattgaatag atagataata ttaaagttat taaagttaaa cgtaaactga 2997301 gtaatgataa tcggagccat tgcaatgaac accatcggaa gcgtgatgta tctcagcttt 2997361 gaaaagacag aagcgccatc aatcgtagct gcttcataca gatcgtccgg gatggattgc 2997421 aatacgcctg ttgagacgag aaagatgtac ggaaatccga gccagccctg catgagaatc 2997481 aatgcaagcc tcgaccaatt ggcatctgtc atccacggaa gcggatctat cccgaagaaa 2997541 gccaagatgt cgtgattcat cgcaccgaag ctatcattaa acagtcccgc aaaaattaaa 2997601 atcgtcacaa aaccgggaac ggcccatggc aaaatcagaa tcgtccgaaa aaaacgttta 2997661 aaccgaaggt ctttctggtt aacaatgatc gcgagaaaaa tccccaaggt gacttgcagt 2997721 gtggatgcag caagtgtcca aaccaccgtc caagccagta catcaaaaaa agtcgacctc 2997781 caaatatcaa ctgtgaaaat atttgcgaac gtttgaaaac cgacccaatc aattaatttt 2997841 gcaggaggag aatgatacaa atcatagttt gtaaacgcta atgcaaagct gaataagata 2997901 ggaaagatca cggcgaaaat taaaataaac aaagatgggc cgctgacgac ataaggatag 2997961 ccctcagaaa tgatatgctg gtattgttcc tttaaggaac ttaatggctt attttcatca 2998021 cgctgttttc cgctttggaa cgcatcgcga agatttacat aatacaccgc aaggccaaag 2998081 caggtcacga tgacagcaat aatcccttcc gccagcagaa aaacggaatt atcccgcggc 2998141 acttctgttc ccagtgtaaa gattccccaa aaccccatat tgagcagatc tccaaagacc 2998201 gcaaaaaacg atgcgcctaa gaaaagaaag acaatacctt ttatccattg cttgttataa 2998261 aattgcccga gtcccggaat gatagaaagc aacaaagcga cttgacgatg ctgcaccgtt 2998321 ttcacctctc ttacaataca aatctagctt tctctttatt ttccgctgtg ctttgcctta 2998381 atttgtcctt tggccgtttc agctgcttga tccaatgctt gtttcggatc tgccttccct 2998441 gttgcaaccg tctgtaatgc tgaatcagcc ggcgtccata tttcattcat ttccggaata 2998501 tttggtgttg gctctgagaa acgggattgt tcagtaacag cccgtgccgc ctcgcttttc 2998561 ataatagccg ggtcattggc tagggatttc acagcaggaa cttctttcgt ttcttcatat 2998621 cgtgttttag aatttttttc atttgccagg aaaacggcta attcttgcgc cagctcttca 2998681 ttctttgaaa atgcactgac gttgtagctt ttgacgccga taaaggagct catgtttttc 2998741 ccattttcca gcttcggcag tttcgtaatg ccataattga ttcctgcatt cgaaaaggct 2998801 tctacattcc atggaccaga aataattgcg gcggcttttc cttctgtgaa cagcgattcc 2998861 aacacgttaa tcccttgttc tccaataatg ccagccggga acaggccatc tttgtaaaac 2998921 ttctgaatca gcgccgcacc tttgacagct ccttcattat tgattccaat gtctgacggg 2998981 ttatagctcc catctttggc ctttccaaaa atgtatccgc catatccgct catcacactt 2999041 tctgcataat aaatttgatc gaatagggct aaaaagccaa atttgctgcc gtcagcagtc 2999101 tttttggaat agtcgtacca ctcttccagc gttttgggca attccttttc tgtgatgaga 2999161 tctttgttgt aaaaaagcac agtcgtttcg accgcttttg gcagtccata aagcttttga 2999221 tctaccattt gagactgaat ggaagcgtca gtataaagtg attgaacgtc ttttttgaca 2999281 tgtaattcct tgagtaatcc ttccgtgaca gcggttccga tttggtcccc tggcattgtt 2999341 aacacgtcag ggcctgtgcc ggccggtcca tccattcgca aatcttcaat ctgcttggca 2999401 tacggttttt caacgacttt gaccttcaca tcatgctctt tttcaaatgc agccacagcg 2999461 tctttaatgc cgttgctctt ttctttatcc tcccatacaa caagctctga cccttttgaa 2999521 ctcgatttgg cgctgctgct ttcctttggg ccgcaagccg ccaaggataa actgacagct 2999581 gcgcagagca tgaatacgga acactttttt gccattttca ttgattgtca ccctttcggt 2999641 aggaatgaaa gcgctttaaa gataatatag catgcctgag aaaatgtgta aacaaactat 2999701 ttacttcata gagtaaattt ttttacctaa ataaaaaatg acttagtgtc ctaagtcatc 2999761 cttaattcat actcttcctg acgattaatt ctgcgcccac atataatgtt tttaccgttc 2999821 ttctcttgtc ctgcacttgt tcaagcagta attgaacagc gtttttacat aattcatgta 2999881 tatcaatatg aaacgtcgtc agaggaggcg agacatactt cgcgaagctg atgttgttga 2999941 tactcacaat gcttaccctg tttggtatgg caattccttt ttcgttcagg gcttgcagac 3000001 agcccactgc aatcgggtcc gctgcaatca taaaagcagt cggaagctga tcgcctaatg 3000061 tgtcgatcgc tgctgacatc aggcggtagc cgttttctac agagaatccg cgatgacaga 3000121 aaatatagcg ctcgtccagc atggcttttt ccctcatata ggatctgaag gtttgttcac 3000181 ggatgtccat ttcatcctga ttggtattcg gatttttgta tgtgccgccg ataaaaccga 3000241 tgctcttatg ccccttctca gtcaggatgt ttaccgtctt ccttgtcatt tgtgccaaat 3000301 cgggccttac cgagtcaaaa tgatcgggat caggagttga atcgatgaac acgccgtttt 3000361 cagtgagatt tctgaggaaa gccagctctt catctgaaaa tgtgccgacg gcaataaacc 3000421 cttccgtatg ttcaggaatg ctctcgattc catccgctat tttataagtg gtcatatcga 3000481 cattgaatgc tttcgccagt ttctctactt ctaatctcat cgttttaaaa tagacatctt 3000541 ctaattcttc tttatctgtc agccaatata aaaacgcaat atgtttcacc agcggcctta 3000601 ctgttttttt gcggtaattg agcttttccg ccgcttcata gattttctcc cgtgtctcat 3000661 caggaacaga aaggctttca tcgttattta aaacgcggga aacggttgag attgaaaatc 3000721 ccgcttcctg cgcgatatct ttaattgtcg ccattgtatc tgcctccatt attcagctcg 3000781 cattgtttta gtaaaatatt ttactttctt tttcacaaat gtcaagtgca caaagccctc 3000841 tggctgccat gtaaaaagac tgaaccattt gcggctcagt ctcagttgtt cgtatcattc 3000901 ggaaccggcg gaattgcccg ggaaatgagt tggttattgc acattttcct cgaaatatcc 3000961 cgaaagcaca tcttccacat tcgtcaaatg cgccagcatg gcggcttccg cctgtgcacc 3001021 gttcccggca gccacagcat tgtaaatccg ttcgtgctcc tcatacagcc gctgaacgga 3001081 ggtcttcttg gaaaacagcc agattttcct cgtttccctc attgtttcca gcagcaatga 3001141 tgacacgtga ttcatcaagt gtttaagaag ttcattttga gaagcgtccg caagcgcaag 3001201 atgaaatgca aagtctgctt tctctcccag ctccccgtcc gcttcaatgc tgcccatttc 3001261 ctttagtgca tcctgaattc tttcgagatc tgcttctgtc cttttttcag ccgctagtga 3001321 agccacgccg atttcaagca gttttctgac ctcgagcagc tgcttgacgt cctctttttt 3001381 catcagaagg gcggctgaga gcggctgaga aatttgattg agctcaaatt ccttcagata 3001441 cgtgccttct ccctgtttca tttcgacaag ccccatcgct tttagcgcag aaagtgcttc 3001501 gcgaaccgct gaacggctga cttgaaagct ctcagcaagc gcctgaacag agtccagttt 3001561 atcccccggc ttcaattcgc catttttgat catatctaat agggcatccg ctacttcttc 3001621 atatattttt ttgttttaat ctgtttatat ttcaatgcaa ttcaccccgt aacttgtagg 3001681 tctggctgtt tacgatctat tatactctgt tttgtgggcc gccaaaagat tttgactatt 3001741 ttgtcaaaaa gtcttgtact ttgatttttt tcaaaatata atgctaggta actggtctta 3001801 ttacccagtc atcagatgat catatcatct atagaaaccg cttacatatg gcgccagttt 3001861 atgtttcaag gaggggtttg ggatgcaatg gacacaggca tatacgccta tagggggaaa 3001921 tttgctatta tcagcgcttg ccgcacttgt accgattatt ttcttttttt gggcactcgc 3001981 gattaaacgg atgaaggggt atacagcagg cttggccaca ttggggatcg cccttatcat 3002041 tgctgtattg gtttatcgta tgccggcgga aaaagcgctg atgtccgcga cacaaggagc 3002101 cgtatacgga ttgttgccga tcggctggat cattgtgacg tctgtttttt tgtataaaat 3002161 cactgtgaaa acgggacagt ttgatatcat tcgcagctct gttctctcga ttactgatga 3002221 ccgacggctt caagctctct tgatcgcttt ttcattcggg gcttttttag aaggggcagc 3002281 aggcttcgga gcgccggtcg ccatttctgc cgcgctgctg gtcggtctcg gctttaatcc 3002341 tctttatgct gcggggatct gtttgatcgc caatacggcg ccggttgcct ttggggcaat 3002401 tgggattcca attacagccg tagaagggcc gacagggatt ccggcgatgg agatttcgca 3002461 aatggttggg cggcagctgc cgtttttatc cgtatttatt cctctttatt taatcatcat 3002521 catgagcggg ttcaggaaag ccttggagat ctggccggcg attctcgtat ccggtgtttc 3002581 ctttgctgtt gttcaatatc tcagttccaa ttttttaggg cctgagctgc ccgatgtttt 3002641 gtcagctctt gtttcaatgg ctgcgcttgc tgtgtttttg aaatggtgga agccgaaaac 3002701 aacattccgg tttgccggtg aacaagagtc ggccgcctca attgaaacgg cgcgcacaaa 3002761 tccggcggcg cctgcataca gaggcggaca gatttttaag gcttggtcgc catttctgct 3002821 gctgacggcg atgatttccg tatggggcat tccatctgtc aaatccgcgc tgaccgggca 3002881 ttatgaaggc tctgcggtgt tcttgaagtg gctgaatgct gttggagaaa aactgacttt 3002941 ttcccccggt gtgccttttt tgaacaatca gattgtcaat gctgacggta cgccgattga 3003001 agcggtttac aagttggagg tgcttggttc ggccggcacc gcgatattga ttgccgcagt 3003061 gctgtcaaaa ttcatcacgg cgatttcgtg gaaagactgg ggaaccgttt ttaaagaaac 3003121 agtccaggaa ttgaagcttc cgattttgac cattgcttct gtcgttggtt ttgcctatgt 3003181 caccaactcc tcgggaatga gcacgacact cgggatgaca ctcgcgctga caggttcgat 3003241 gtttaccttc ttttcgcccg ttctcggctg gctcggcgtc ttcattaccg gctcggatac 3003301 ttctgccaac ctgctgttcg gcaacctgca gaaagtcacc gcattatcag tcggcatgga 3003361 ccccgttctg tctgtggccg ccaactcttc aggcggtgtc acaggaaaaa tgatttcacc 3003421 gcagtcgata gcggtggcgt gcgccgcggt aggactcgcc ggaaaggagt cagatctttt 3003481 ccgctttacc attaaacaca gtctgttttt gctgctgctc gtctgtatca tcaccttttt 3003541 gcagcatcac gtattcagct ggatgattcc ttaaaaaaat cctcccgtct agggaggatt 3003601 ttatttatat cgctttctcg ctgccgatga cggaatattc atttgatcgc gatattttgc 3003661 cacggtgcgt ctcgagattt ggatgccgtg ttgttcatac agcaaatcga caagcttttg 3003721 gtctgaaagc ggttttgttt tgtcctcttg attgatcagg ttttccagat gcgttttgac 3003781 tgcataattc gacgcatctc catcacctga agcctcggct tttgctgaga aaaagagttt 3003841 catctcaaac agcccgtaag gcgtttgtat tgttttccct ttaatggccc ggctcacagt 3003901 tgattcatga aggcttagac agtctgccac ctctctgaga gtcagcggct tcattgcgct 3003961 tcgccctttc agaaagaaat ccttttggcg tgtgatcagt tcattgataa ttctcgtgat 3004021 tgtctgtttt cgctgccgca gcgcgcggct cagccagcgc cactcctgat atttcgcaga 3004081 taaataggag acagtatcct gacaggagcc ggatgataaa agcgttctgt actgcggatg 3004141 cagatcgatc tcgggaaacg agcgggtatt cagttccgct gcgatgtgcc cattttttac 3004201 ggtgataaaa atgtcaggct caatatacac atcttgctct ggccgggcaa acagaaggcc 3004261 aggtctagga tgaagagccg cgatatcatc tgagatatct tgaatggtat gaagcggaat 3004321 tcccgtctct actgaaagcg ttttccattt tttttgcgca aaagcatcaa aatgagctga 3004381 aaccagcatt tccgcttgtt catttctgtt cggcagccgc tgtaattgaa gaaggatgca 3004441 ttcctgcaaa gatctcgcgc cgattccagc cggttctaac gactggagtt ttgccaaaac 3004501 agcctccgct tccttggccg atacagataa tcgccgtgct gcctcctcta tatcttcttc 3004561 caagtacccg tttgaatcaa gcgaatgaat cagataatta aaaatctttt tttcagtgtt 3004621 tgtcagattc atatcgagtg actgctgttt taacgcatcc tgcaatgttt tttgcggatt 3004681 acttaattga aggcccgctt cctgtgcatt catcctgttt ttgtttgttt tatggtaaga 3004741 tagtggcggt gtgtctgttt cctttcgttc aataagaggg ttttccagtg agagctcatc 3004801 aatgtactcg gcgagttctg ccgaatgata gccaagcagc gtgatggcct gcctgagctc 3004861 ctgtgtcagt tgaggcttta atacttgtac ttgctgaagt ttcatatcca tcttgctcac 3004921 tcccctttct tcattgtaca tgattgagat cacaccgtat acatttatga aaaaggagct 3004981 gccaaagaaa tgtctgaact tttttccgtc ccttatttta ttgagaattt aaaacagcat 3005041 attgaaatga atcagtctga ggataaaatc cacgcgatga acagctacta ccgttccgtc 3005101 gtctcaacac tagtgcagga ccagctgacg aaaaacgcag ttgtcctgaa acggattcag 3005161 catttagatg aagcatacaa caaagtcaaa cgtggagaat caaaataaac cttccgaatt 3005221 cgggaagatg atgatcggtt aaagggctaa cgttcgcatc tataggggaa atctgtttat 3005281 aatgggggaa aaagggagag aacacaatga ctcatcaaat agtaacgact caatacggca 3005341 aagtaaaagg cacaacggaa aacggcgtac ataagtggaa aggcatcccc tatgccaagc 3005401 cgcctgtcgg acaatggcgt tttaaagcac ctgagccgcc tgaagtgtgg gaagatgtgc 3005461 ttgatgccac agcgtacggc tctatttgcc cgcagccgtc tgatttgctg tcactttcgt 3005521 atactgagct gccccgccag tccgaggatt gcttgtatgt caatgtattt gcgcctgaca 3005581 ccccaagtaa aaatcttcct gtcatggtgt ggattcacgg aggcgctttt tatctaggag 3005641 cgggcagtga gccattgtat gacggatcaa aacttgcggc acagggagaa gtcattgtcg 3005701 ttacattgaa ctatcggctg gggccgtttg gctttttgca cttgtcttca tttaatgagg 3005761 cgtattctga taaccttggg cttttagacc aagccgccgc gctgaaatgg gtgcgagaga 3005821 atatttcagc gtttggcggt gatcccgata acgtaacagt atttggagaa tccgccggcg 3005881 ggatgagcat tgccgcgctg cttgctatgc ctgcggcaaa aggcctgttc cagaaagcaa 3005941 tcatggaaag cggcgcttct cgaacgatga cgaaagaaca agcggcgagc acctcggcag 3006001 cctttttaca ggtccttggg attaacgagg gccaactgga taaattgcat acggtttctg 3006061 cggaagattt gctaaaagcg gctgatcagc ttcggattgc agaaaaagaa aatatctttc 3006121 agctgttctt ccagcccgcc cttgatccga aaacgctgcc tgaagaacca gaaaaagcga 3006181 tcgcagaagg ggctgcttcc ggtattccgc tattaattgg aacaacccgt gatgaaggat 3006241 atttattttt caccccggat tcagacgttc attctcagga aacgcttgat gcagcgctcg 3006301 agtatttact agggaagccg ctggcagaga aagttgccga tttgtatccg cgttctctgg 3006361 aaagccaaat tcatatgatg actgatttat tattttggcg ccctgccgtc gcctatgcat 3006421 ccgcacagtc tcattacgcc cctgtctgga tgtacaggtt cgattggcac ccgaagaagc 3006481 cgccgtacaa taaagcgttt cacgcattag agcttccttt tgtctttgga aatctggacg 3006541 gattggaacg aatggcaaaa gcggagatta cggatgaggt gaaacagctt tctcacacga 3006601 tacaatcagc gtggatcacg ttcgccaaaa caggaaaccc aagcaccgaa gctgtgaatt 3006661 ggcctgcgta tcatgaagaa acgagagaga cgctgatttt agactcagag attacgatcg 3006721 aaaacgatcc cgaatctgaa aaaaggcaga agctattccc ttcaaaagga gaataaatat 3006781 ggggaaaaca ggatacattg gtgctgccat tgttgtggca gcttgtatca ttattttgtc 3006841 ggccgtggta tgtttacggg acacagtcta ttaccagcct atgcgctgga ctggcatcat 3006901 actgtttttc gcgggaattg tgatggttcc cgcatactca gcaaaaagaa aacccggaaa 3006961 agagaagtaa ttctcttttc cgggttttta tgtttattat aatcttcccg cgcgaatatc 3007021 gtctgtcatt ccctcataag gagccttcga aatcacttct tcgttgtcga ctccttcatt 3007081 tttcagaaat gtaatttccg caaattcagg tacaacgtat tttggatacg tttcatattt 3007141 ttcgcgggat tctttcatca aatcaatgtg gtcattttgg tagcaaaccg taatttcagg 3007201 atgttcatgc acccatttcg ggaagaaaat aatgccatgc atgcgttttt catttggcat 3007261 aaagtttaat gaaacatccg tgccagtcgg ctctgtccaa gacactttat atacgccttc 3007321 tgtcagtttg acaatattca cttcctgatc tcgaacccag cgtccggcaa ccattccgct 3007381 atgaattcta taatcaattg tatggtcgtt tttaatataa atctcgtatt cccatccgtt 3007441 ttcatacgta taaatcatgt ggcttccgat aaagttttcc atcttacaca ctctccttag 3007501 tcttttactg tacttcataa atgtctagta gaacgtaatc aggggttctt tctgcggaac 3007561 cgataaacaa gcggtcatgg agccattgat agacttcact gcctgtttca aacgtcggta 3007621 ccgtacgaaa ataaacatgc tccggttcaa taatttcccc ggctgccgct tgttttcgaa 3007681 acggcttgct gacttgccgt attccattgt tttcaatgta aatcagttca tgatctgctg 3007741 tttcaatcac atacctggca gataaatctg ttctgccgtt agcgcgaatc atttgtgaat 3007801 cggcaccgcc cggcaaaata cgtcccttta cttccccggt tattgttccc gaacgaatcg 3007861 gaatgaatca tctcagtccc aggcttgtct caccaatcgt gataggcgga tcaaccttga 3007921 tttctaaaga ggcgaatggt tttaaaaccg gcttcttcac gagaaccacc tcaccttcag 3007981 aaaaaatcat gtaactattt acatgttcac tttaacacca ttgcagttaa ctgtcaaaca 3008041 ataggaacat aaaaaaacaa ggactgtttg aagacagtcc ttgtctgaag ctagctttga 3008101 taagcaagat atgtgctgac agtgcttttg gcaagacagg cagaggaatc tataatcgga 3008161 atctcacttt gaatatgatc taacaccgca tttaaatccg tgcaggctga aatgatgatg 3008221 tctgcatgct gactgatttc ttcatatagc gtctgccaca atgcttgtgt atgctgcata 3008281 tgatttggct gtttgattgc ggcgataagc tggttcacag cctgctgcca atggtccttg 3008341 tgaataactt cttgtccatt tcccttcaga actttttggt agatggcgga ttggatggtt 3008401 ggctctgttc ctaaaaccac cgcttttttt gcgggatgcg gaatctcttt tatcgtttcc 3008461 tcaacaatat gcaacatagg aactgacaat gcctgctgaa tctcttcata gtagacatgc 3008521 gccgtattac aaggcagcgc aatgaaatcc acgcctgttt tctcgagctt taccgctccg 3008581 tcgataatcg cttttttcat ctcgtcatgg tcaattggac gatctgcata gaagggcgtc 3008641 gggcatgaat agatcatcat gtgcggatag tcaatatcgt ttgaagcccc atacagcttc 3008701 tgacagtaat caatcacctt atcaataaac ggcgaggtcg atttcggccc cattccggct 3008761 aatattccga tcatcaaatt cattcctttc tacttcgtac ggaccgcttc ttcctctgag 3008821 ccatcctcat agaggataaa gcttttcgca gcatcctcac ctaatgtaaa ctcgacttca 3008881 acagacaatg ctcgcagaaa gaaacgggtt tccgaggaag gaaataactc cagtctcagc 3008941 tgtccggcga tctccaaata aagccgttca ttctcggttg tcacctgtgc agccgtccca 3009001 tcctgcaaca ggtagctgcc aacatagcgg ctgtatatcg ccgtatcaat tgcttttttc 3009061 tttttatcag caggacgttc cgggacatca tatggctggc caaatagaat atgttccgcc 3009121 gccttcagaa tcgcttgttc atattcagta tcctcttcct tattactcaa atagatcagc 3009181 gttttacgat gatcgatata tcggatcatc atcgtcgaat agccgggcca tcctccgctg 3009241 tggctgacaa tccgcccttt ttcaggactg ttttgcagca cccagccaaa gccataatca 3009301 attgtttctc cattgttgag gcgcactgga gaaaacgcag attccttaga agccttgctg 3009361 atgaaatcgt cctgatataa agcctgatca aatcgaaaca aatcgcttgt gacagagtta 3009421 accgtcccat ctccctgtat gccatcgaga tacacaacat agttcgtttc ctccagctca 3009481 tcagggagga cgtatgtttc ggaatgtaca tcatacacat atccatatgc ataatgatca 3009541 attcgctcag gcgaaagcct cctgttatac actcttgttt cattcatgcc tgccggtaaa 3009601 aaaatacttg tttttataaa atccgcatag ctcatgccag atgctttttc aatgataacc 3009661 gccagcagca cataccccgt attgctgtac atccagcctt cattcggttc aaaataacca 3009721 gatagcccct cattcatcag catatcgaca atatcctgat tcaccgcaat cttgtgtgaa 3009781 tcccaattgg caaaaaacca tcccatataa tcaggaagcc ctgacgtatg gttcaataaa 3009841 tgccgaatcg ttacgccctg atacggaaaa ccgggcagcc agcgatccac tttatcctca 3009901 tagccaagaa tccccttctc ctccagcaag atgattccca atgctgtaaa aggctttgac 3009961 aaagacgcta actcaaacaa agagttggtt ttcaacgggc gtttttccgt catttccgca 3010021 tagccaaaag agtggtgata taaaatatcg ccaccctccg cagccagaac cgtcccgtta 3010081 aactgatgtt tttcgcctaa tgtctcaaat aacgtctgaa gatgctttct tttattctgc 3010141 ttcattcctc cacctcccat atctctgtac gttactaacc tactaacgtt tcaaatattt 3010201 tgaaaaatcc ttcagttaga gatccttttt aacccatcac atatacctgc cgttcactat 3010261 tatttagtga aatgagatat tatgatattt tctgaattgt gattaaaaag gcaactttat 3010321 gcccatgcaa cagaaactat aaaaaataca gagaatgaaa agaaacagat agatttttta 3010381 gttctttagg cccgtagtct gcaaatcctt ttatgatttt ctatcaaaca aaagaggaaa 3010441 atagaccagt tgcaatccaa acgagagtct aatagaatga ggtcgaaaag taaatcgcgc 3010501 gggtttgtta ctgataaagc aggcaagacc taaaatgtgt aaagggcaaa gtgtatactt 3010561 tggcgtcacc ccttacatat tttaggtctt tttttattgt gcgtaactaa cttgccatct 3010621 tcaaacagga gggctggaag aagcagaccg ctaacacagt acataaaaaa ggagacatga 3010681 acgatgaaca tcaaaaagtt tgcaaaacaa gcaacagtat taacctttac taccgcactg 3010741 ctggcaggag gcgcaactca agcgtttgcg aaagaaacga accaaaagcc atataaggaa 3010801 acatacggca tttcccatat tacacgccat gatatgctgc aaatccctga acagcaaaaa 3010861 aatgaaaaat atcaagttcc tgaattcgat tcgtccacaa ttaaaaatat ctcttctgca 3010921 aaaggcctgg acgtttggga cagctggcca ttacaaaacg ctgacggcac tgtcgcaaac 3010981 tatcacggct accacatcgt ctttgcatta gccggagatc ctaaaaatgc ggatgacaca 3011041 tcgatttaca tgttctatca aaaagtcggc gaaacttcta ttgacagctg gaaaaacgct 3011101 ggccgcgtct ttaaagacag cgacaaattc gatgcaaatg attctatcct aaaagaccaa 3011161 acacaagaat ggtcaggttc agccacattt acatctgacg gaaaaatccg tttattctac 3011221 actgatttct ccggtaaaca ttacggcaaa caaacactga caactgcaca agttaacgta 3011281 tcagcatcag acagctcttt gaacatcaac ggtgtagagg attataaatc aatctttgac 3011341 ggtgacggaa aaacgtatca aaatgtacag cagttcatcg atgaaggcaa ctacagctca 3011401 ggcgacaacc atacgctgag agatcctcac tacgtagaag ataaaggcca caaatactta 3011461 gtatttgaag caaacactgg aactgaagat ggctaccaag gcgaagaatc tttatttaac 3011521 aaagcatact atggcaaaag cacatcattc ttccgtcaag aaagtcaaaa acttctgcaa 3011581 agcgataaaa aacgcacggc tgagttagca aacggcgctc tcggtatgat tgagctaaac 3011641 gatgattaca cactgaaaaa agtgatgaaa ccgctgattg catctaacac agtaacagat 3011701 gaaattgaac gcgcgaacgt ctttaaaatg aacggcaaat ggtacctgtt cactgactcc 3011761 cgcggatcaa aaatgacgat tgacggcatt acgtctaacg atatttacat gcttggttat 3011821 gtttctaatt ctttaactgg cccatacaag ccgctgaaca aaactggcct tgtgttaaaa 3011881 atggatcttg atcctaacga tgtaaccttt acttactcac acttcgctgt acctcaagcg 3011941 aaaggaaaca atgtcgtgat tacaagctat atgacaaaca gaggattcta cgcagacaaa 3012001 caatcaacgt ttgcgccaag cttcctgctg aacatcaaag gcaagaaaac atctgttgtc 3012061 aaagacagca tccttgaaca aggacaatta acagttaaca aataaaaacg caaaagaaaa 3012121 tgccgatatc ctattggcat tttcttttat ttcttatcaa cataaaggtg aatcccatat 3012181 gaactatata aaagcaggca aatggctaac cgtattccta acctttttag gaatattgct 3012241 gtttatcgac ttatttccaa aagaagaaca tgaccaaaaa acaaaatcaa aacagaagcc 3012301 ggactaccgg gcggcatatc attttacgac gccggataaa tggaaaaatg accctcaaaa 3012361 accgatctat tttgatggca agtatcatta tttctatcta tataaccggg attacccaaa 3012421 aggcaacggc acagaatggc gccatgccgt ctcagaggat ttggtgcact ggaccgatga 3012481 aggcgtggcg attccgaaat atacaaaccc ggacggtgat atttggaccg gttccgtcgt 3012541 ggtggataaa gagaacacag ccggcttcgg gaaaaatgcg cttgtcgcga ttgtgacaca 3012601 gccctcagcc aaagacaaaa aacaggaaca atatttgtgg tacagcacag ataagggaaa 3012661 atcattcaaa ttctacagtg gcaaccccgt tatgcctaat ccgggcacag acgatttcag 3012721 agatccgaaa gtcatatggg atgaccaaga taacaaatgg gtcatggtca tggctgaagg 3012781 atcaaaaatc ggcttttatg aatccgataa tcttaaggac tggcattaca caagcggatt 3012841 cttcccagaa caggcgggaa tggtggaatg tcccgacctc tacatgatgc gggcaagcga 3012901 cggaacgaat aagtgggttc tcggtgccag cgcgaatggc aaaccgtggg gcaaaccaaa 3012961 tacgtacgcc tactggaccg gaagcttcga cggaaaagaa ttcaaagcgg atcagactga 3013021 agcccaatgg cttgactatg gcttcgactg gtatggcggt gtgacgttcg aagacagcaa 3013081 aagcacagat ccattagaaa agcggtatgc gcttgcctgg atgaacaatt gggattatgc 3013141 caacaacacc ccgacaatga agaacggctt taacggcaca gattctgtca tacgcgaact 3013201 ccggctgaag gagcaggatg gaacatacag cctcgtctca cagccgattg aagctttgga 3013261 gcagctgact gtttcaactg acgaaataga ggatcaggat gtgaacggat caaaaacatt 3013321 gtcgataaca ggtgatacgt accagcttga tacggatctt tcttggtcag agctaaagaa 3013381 tgcaggcgtc aggctcagag aatcagaaga ccaaaaacgc catattgatg tcggcatttt 3013441 cgctgaaggc ggctatgctt atgtcaatag agcagccaca aatcagcctg acaaaagcaa 3013501 tacctatgtc gaaagcaaag ctccttatga tgtaaacaaa cgtaaggtgc atttgaaaat 3013561 acttgtcgat aaaacaacga tagaagtatt tgttggcgac gggaaaaccg ttttttcaaa 3013621 tgaagtcttc ccaaagcctg aagataaagg aattaccctt tattctgacg gcggcacagc 3013681 ctccttcaaa aatataacag tgaaacactt tgattcgatt catgaataaa aacaggggcg 3013741 gcgcaggctg cccctgtttt tttattagga gcggtattct ctgttacata ttgggcattg 3013801 taaggaatat aaggctggtt tcaaaggagg aagcgaatgt ctaaacaagg aaattttcaa 3013861 aaatcaatgt cgctgtttga tctgattttg attgggatgg gagccatctt tggatcagcg 3013921 tggctgttcg ctgtcagtaa tgtcgcttca aaagcagggc cctccggcgc tttttcctgg 3013981 atcctcggag gagccattat tttgttaatc gggcttgtat atgcggagct cggagccgct 3014041 ctgccccgta ccggaggcat cattcgatac cccgtttatt cacatggcca ccttgtcggc 3014101 tacttaattt cgtttgtcac gattgtcgct tatacaagct tgatttcaat tgaagtgaca 3014161 gctgtgcgcc agtatgtggc ctattggttt cccggcctga ccattaaagg gtctgattcg 3014221 cctaccattt ccggctggat cttgcagttt gccctattat gcttgttttt cctgctgaat 3014281 tattggagcg tcaaaacctt cgctaaggcg aatttcatca tatcgatttt taaatatatt 3014341 gtgccgatta ccatcattat tgtgctgatc tttcattttc agccggagaa tttatccgtt 3014401 caaggatttg caccgtttgg atttacaggt attcaggctg ccatctcgac aggcggcgtc 3014461 atgtttgcgt atctcggcct gcatccgatt gtatctgtag caggtgaagt ccaaaatcca 3014521 aaacgcaata tcccgatcgc tttaatcatt tgcatcatcg tttcaaccat catttatact 3014581 gttttgcagg tcacctttat tggtgcaatc ccgacagaaa cactgaaaca tggctggccg 3014641 gcaattggcc gggagttctc attgccgttt aaggatattg cggtcatgct cgggttaggc 3014701 tggcttgcaa cgcttgtcat tttagacgcc attctgtctc ccggaggaaa cgggaatatc 3014761 tttatgaata cgacatcccg ccttgtttac gcctgggcgc gtaacggcac attatttggc 3014821 atattctcaa aggtcaataa agatacgggg acaccccgcg cttcgctttg gctttcgttt 3014881 gccctgtcca ttttctggac acttcccttt ccttcgtgga acgcgctcgt caatgtctgt 3014941 tcagtcgcgc tcattctttc atatgcgatt gcacccattt cttcagctgc gctgagggtc 3015001 aacgcgaagg acttaaacag gccgttttat ttaaagggaa tgagcattat cgggccgctt 3015061 tcctttatat ttacagcgtt tatcgtgtac tggtcaggat ggaaaacagt ctcctggctg 3015121 ctcggttcac aactcgtgat gtttttgatc tatctctgtt tcagcaaata tacgcctaaa 3015181 gaagatgtca gccttgctca gcagctgaaa tcagcctggt ggcttatcgg gttttatatt 3015241 atgatgctga tcttttccta catcggttct ttcggacatg gtttagggat tatcagcaat 3015301 cccgtcgacc tcattttagt cgcgatcggc tcacttgcga tttattactg ggcaaagtat 3015361 accgggctcc caaaagccgc cattgattat gataaataaa gaagcaagag gttttcttgc 3015421 ttctttattc tttacaaaca aacatacacg cgataaaatg aatgagagtc agtcattact 3015481 ggaggtgttc ctcatgccaa aacaaacatc gggtaaatac gaaaaaatat tgcaggcggc 3015541 catagaagtc atttctgaaa aaggcctcga caaagcttct atttctgata ttgtcaaaaa 3015601 ggccggcact gcccaaggaa cattctattt gtatttttca tctaaaaatg ccctcatacc 3015661 ggccattgca gaaaatctcc tcacccatac acttgatcaa atcaaaggta ggctccatgg 3015721 ggacgaggat ttttggaccg ttttagatat attaattgat gagacatttc tcattacaga 3015781 acgccataag gatattattg tcctctgtta ttccgggctt gcgatcgacc actccatgga 3015841 aaaatgggag acgatctatc agccttatta ttcctggctt gaaaaaatca tcaacaaggc 3015901 cattgcaaac catgaggtaa cggaaggaat caattcaaaa tggacggcca gaacgattat 3015961 caacttggtc gagaatactg cggaacgatt ctatatcgga tttgaacaag atgaaaatgt 3016021 tgaagtgtat aaaaaggaaa ttttcacttt cttaaaacgg agcttaggta ctgcttaaaa 3016081 aatgactggg taacaccgct cattttttaa tgccctaaaa atgactgacg ttcattcata 3016141 aaatagagag gtgtttcatt tgaattgggt tcttgttttt attgcagggc ttttagaggt 3016201 tgtttgggcc tcttccctca aacatgccga ttcgcttttg gattggatca tcatttttat 3016261 cttaatcgcg gtcagcttta tcctgttgat ccgctcttat caaaaaatcc cgatggccgc 3016321 ggcgtacact gtgtttgtgg gaatcggaac cgtcggaaca tatctgactg gaattgttct 3016381 gggcgaatcc ttctcagcag cccaaatgtt ctttttagct ttattgctgg ctggcatttt 3016441 aggaatgaaa ttatttacga aagaaagcaa atctcagccg ggaggtgaaa aataatggca 3016501 tggtttttat tagtgattgc cggcatagaa gaaattatag ctgccattgc catgaaatat 3016561 atagacggaa caagaaaaaa atggccgatc attgtgatga ctgttggatt cggcttatcc 3016621 ttttactgcc tgtcccaagc gatgatcgtc ctgcctgccg gagtcgcata tgccgtctgg 3016681 actggcattg gaagcattgg tgtttcggcg gtcgggctca tctggtttaa ggagcggttt 3016741 cagctttcac aggtgatttc actttgcctt atcctagccg gcgtcatcgg cctgcgtctt 3016801 acgtcatctt cataaaatca aggcatatac agctgtatat gcctttgcca ttaagcttcg 3016861 tgatgttttt gaagatgaag cggcggcggg atgagccagc ctttgttttt tagcagcctt 3016921 aagtattttg cgccggttgc cgctttcgac atatgaaatt gcccaaacat catggcaata 3016981 tcctcacgaa tcgattgccc catcattttg ctgcatgtca caagacctgc agcattttct 3017041 gctgccgcgg aagccgccac atccggatcg agaaaccgtg caccaggcgg aatatcgtta 3017101 agatctgctg tcggcggttc aggagaagcc ggcggcagcg ccaccccgtt ttctttcagg 3017161 atcgtgctga cctgtttgat ttcatcttgg catttctcaa tagactcacg aagcagcttc 3017221 ttcaggtcgt catcaccgac atgattcaat agcatttggt aattgccgac cattttattg 3017281 cccgccatca cataactcca caagccgaat acctcaccgt aatgcatcgg ttcatcctgc 3017341 ggatttccgc ttaaaatacc catgctcatt ctcctcccat attcaatatt gcacatttca 3017401 taacgtgccc aagcggagga acatttatgt ttcagcggaa aagatttatg aaatgaaaca 3017461 aaacaaaaaa gacaagagtg gcaagttgcc aaaccattgt ctttcctgtt gtttgattgg 3017521 acgcactgaa gggattcgca ccccgacaga caagataccg gaaaccattc aagtgctttt 3017581 tagtatgagt cattgattct gtctttaata aactttaacg agatggcggg atgctttgcg 3017641 gaaaacgaaa tacattttcg gggtcatatt tcgcctttat ttctcgaagc cgcgcaaagt 3017701 ttgcgccata atattctttt ccgaagtttt caatgttttg atctggaaca ttaacatatg 3017761 aacctgctac atatggttgc atcagctgac gcactctttc aactgatgca agatttgaat 3017821 cttcttgtga tttatttttc caactagccg tccattccgt ataaaataat ggatggcgcc 3017881 aaaaaaaggc agtttcgtct ttagggactc tgcttatagc accaccccaa ttgataaaaa 3017941 agaaattggc ttctgttcca gtagcatctt ccaaaaattt tctcatgatt gaaatgggtt 3018001 cgtcagacca aaaatcatga ccccatgccg aggagaattt aacactctga tcatttctgc 3018061 cagggatggg ttcgtcaggg tctaagaaat ctatagcatc tggatagtat aatgttttga 3018121 tatctgcttc tgttggagtt cccgcatgta ataaaggttt taataatcga atcaattcag 3018181 ttttcgaacc gaggaaaatt ccttctgcat gacacaaacc atttattttg ctgtaaattt 3018241 caaggtagca tcctaatcgt tcatctacaa acggagccca tttctgccaa gctttaaata 3018301 ccgtttctaa ttgttcccac ggccagataa tattgaagac ggttgcagtt ttaggggcac 3018361 gatgaacttt gaatgtatat tgggtattat atccaaagtt acctcctcct ccgcctctag 3018421 aagcccatag caaatcctca ttgtgagatt gatctgcgtg aataatcctt ccttttgcat 3018481 ctaccgtttt cagcgcgaga aggttatcac ttataaggcc aatcgatcgt gagagtacac 3018541 caaatccgcc gcccatcgta attcccccga ttccaactgt tgggctatct ccaaacggag 3018601 ccataaaacc gtctcgagct aatcccttta caagcgggcc aacgggaata ccagtttgaa 3018661 cggttgcaat agcgttttct tcatctaaga aaactttatt catgtcactc acatcaataa 3018721 caattcctcc acttactact gaaaggttct tatctaaagc atggcgaccg cttctgacac 3018781 gtaagggcac tttattctca cgagcccatt taatggcatt acttacatcg tatgaatttt 3018841 gcgcaaaaac aaagacaaga ggatagacat ccacataagg gttccaattc ttaatagcct 3018901 ctgtatagcc ggggtctcct ttgaagatta cacgccctgt caactgtgtt gatcccatat 3018961 attatttcac tcccaaagaa attcgattca gatactaaaa tatgcaggag ctggataatc 3019021 gcatagacaa atgatctacg aactataaat ataatacgct aaggcctttt tcgtcggtga 3019081 ggtctgctga gaaacatttt tcaaacaatt ttgagcaaac ttcctgtcca atcctccaac 3019141 aagcgttttt tcttatcgtt tttaggagca gtgtccagtt tttttcggag tgaatattcg 3019201 tttaggccaa aagaaaagag agatgaagaa gtgtttagta ccagaggtat acatccatac 3019261 aacagactct agatcatcat atactgaatg tatgtagaaa ggagacatca gctttggcaa 3019321 aatatcggat tatgaccttt gacggcggcg gtaccttagg tgctttaagt ttacaactat 3019381 taaacagatt ggctaggcaa aacccgaagt taattagtcg aacccatgta ttttcgggaa 3019441 attcaatcgg ttcatttact gcccttgcat tagcaagcgg aagatctccg agggaaacac 3019501 ttcagtattt tgaggatgaa atcctacccg cattcagcat ttcccggcca ggcggacctg 3019561 ttttcaacca acaattaccc tattccggtt ttattaaagc ggtaagaaat tttttcccag 3019621 cagatcttca acttatagat ttaagaaaac gaattgttgt cccatcattc aaattatact 3019681 ctcaaaaact ggaccgttgg actcctgtct tatttcacaa ttttcccggc tctccctatt 3019741 taaatgaaaa agtgagtgat gtcatactgc ggagcagcgg tgctcccgcg acgcaacgcg 3019801 cctatcaaaa ctatgtggac ggatatgtag tagcaacgaa tcccagtaca gccagtatcg 3019861 cgtttgcagt tggtaaagcc aacgtgccat tggatcaaat tgcggtattg tccatcggaa 3019921 caggtgaagc cccgactcgg ttaagaagag atacgagggg atggggaatg gtaagtgcag 3019981 ataacatacg tcccgaaaat ctgaagaacc ttcctccaaa ttggggagtc cttttggaca 3020041 ggtcgcctaa tgaaccttta ctgccatttc ttcagatgat tgctggcggt aatgggtact 3020101 atgaatccat ggtcagtgcg aatcttctgg gagatcgttt tttccggtta gatccgcgga 3020161 ttccgaactt ctccaaaacg gaccctgccg tcgttcccgc tgtcattgaa attgcgaaca 3020221 aaacaaactt acagcctgcg aatcaattta tagagaagaa ctgggggagc aaataattat 3020281 ttattttaaa tcaattctcg cttatacaat tttgtccgag agaagattct caaaataaat 3020341 acaggcaatg ggtagaaccg gattttttta aaggtttgtt aatcacaagc taataagatg 3020401 aatgaaaaaa tcaattcata cttcttcttt tgaaagtgag ggttcaaact aaagaatgta 3020461 attgaaatgt tactctaagg tatgcaattc cctttttcac acaaaaaaag acaagagcgg 3020521 caaatcgcca aacccttgtc tttcctgttg ttctattgga cgcgctcgga gggattcgaa 3020581 cccccgacag acgtggtacc ggaaaccacc gctctatcca actgagctac gagcgcatat 3020641 agactgcgtt atgagaacgt cagcacaact aattatacga taattccttt caaataacaa 3020701 ccctctattt cgagaggccg ttttttaaat agacaaagca tcttaattgg caatctgaca 3020761 tacgatggtt tgaacccctg tatttttggg gaaaatggga aaaagagacg actttgcata 3020821 tcaggccagc tttttgtttg acctttattg accaaaaatg tatcatgtaa ctacatactt 3020881 acctaaaagg tgaaggagga gcattatgaa tttaatacct acagtcattg aacaaacgaa 3020941 ccgcggggaa agagcgtatg acatttattc tcgtctatta aaggatcgta tcatcatgct 3021001 tggatctgcg attgatgaca acgttgcgaa ctccatcgtg tcacagcttt tattcttagc 3021061 agcagaagac cctgaaaaag aaatttctct ttacatcaac agcccgggcg gctctattac 3021121 agccggtatg gcgatctatg ataccatgca gtttattaag ccgaaggtat ctacaatttg 3021181 tatcggtatg gctgcgtcaa tgggcgcgtt cctgcttgca gccggcgaaa aaggcaaacg 3021241 ctatgcgctt ccaaacagtg aagtcatgat tcaccagcct cttggcggtg cgcaaggtca 3021301 agcgacagaa attgaaattg ctgcgaaacg cattctcttg cttcgcgaca aattaaacaa 3021361 agtcctagct gaacgtactg gccagccgct tgaagtgatc gaacgcgaca cagaccgtga 3021421 taacttcaag tctgctgaag aagcgcttga atacggcctg attgacaaaa ttttgactca 3021481 cacagaagac aaaaagtaat aacacaacct gcaagagctg cgtctcttgc aggttttttt 3021541 catttcaagg aattgactcc cttattctat actgctccca ttcctcatgt aacagctcaa 3021601 gcgtcaaatc actcgtctgc ctcacaacca gatcagcacc aagcatcggc tgtccttgac 3021661 cgacaccaac cgcaaacatc cccgcagatt tgattgcaga aatgcctgct tctgcgtctt 3021721 ctattgccgc gcaatcagca ggggaaacat cgagcatcgc tgcagctgtt aaaaagatgt 3021781 caggatcagg cttccccttc gcaagagtcg tcggatcaac aatggcatga aaatcatcga 3021841 taattgccaa gcgtcttaaa atcttaggag cattgcgact tgaagatgct aacccgattt 3021901 ttatattttc gtttttcaat tgacatagaa gcctgccaat ccccggtaaa agatcttccg 3021961 gcgtcaattt gctgatcagc atttgataat cgcgattttt ccgatgcata agctcttgtt 3022021 tctccgcatt tgtatacttt gtttccgccc cgccaaagat caatatgctt tcaagtgact 3022081 cttctctgct gattcctttt agcctttcat tcatgtctct gtcaaaaggg atatcgattt 3022141 gttctgcgat gtgcttccaa gcgagaaaat gatattcagc agtatctgtt atcactccgt 3022201 ctaaatcaaa aatgaccgct ttcatatact aatgcccatc acagcttcat aaggtttgag 3022261 gctaatactc tttaagtcag cccgctcctg cggatagttt gaaattagca ctttccaacg 3022321 ctcatgaatc agttctggag gcgcttcgaa cagagccttt tcttccgata aattcacaac 3022381 gacaagaagc ttttcccctc gatattctcg aaggtaagaa aagacctgcg gatcattctc 3022441 ctgcaacagc tgataatcgc catatatcat aatcttatat tgctttcgta attgaatgag 3022501 cttctgatag taaaagaaaa tcgaatcttg atcttccaaa gactctttca cattgatatc 3022561 ttgatagcgg gaatttaccg gtatccacgg gtctccggct gtgaatcccg catgttttcc 3022621 ggcatcccac tgcatcggtg ttctcgcatg atcccttcct tttatcatca cggctttgac 3022681 aaactctttt tctgacatcg ttttgttttc gacgactagt tcacgatatg cattctttat 3022741 ttcaagatca tcatacatct ccagcggcat atcgctgttg accatgccga tttcttctcc 3022801 ctggtaaata aacggcgttc ctttcatgcc gtgcagaacc gttgcaaatg ccttcgcaca 3022861 ttccttacgc agtttcctgt cattgcccca gcgggaaata accctcggct ggtcatggtt 3022921 ctcaaaataa agggtattcc agccgacatt cattaacccg gtctgccacc ttgtcatcgt 3022981 cttttttaaa gcaatcaaat caaacggctt gatctgccat ttcccatttg gcgagttttg 3023041 ttctttatca atatccatat gttcaaatgt aaagatcata ttcagctctt gcctgcttgc 3023101 atctgtgtac tttttcgcct cttcaatatc agagccgttt gcctctccga ctgtcatgca 3023161 gtcgtaatga gaaagcactt ccctgttcat ctcttgaata aactcatgaa gacgtgggcc 3023221 gttagagtga taacggccga caatatagct gcggctgtga tccgtttcgt agtccggaaa 3023281 atcggtgtat ttagaaatag agccaatcac atccatccgc cagccgtcaa cgcctctatc 3023341 catccagaat ctcattacat cataaacttc ccggcgaacg gcttcgtttt cccaatttaa 3023401 atcaggctgt tttttcgaaa agtagtgcaa ataatactgc cctgttcctt catcgtatgt 3023461 ccacgctgag cctgaaaaga tcgatcccca attattcggc tctgagccgt ccggtttagg 3023521 atctttccaa agataataat cccggtaagg attgtccttc gacttgcggc tttcagcaaa 3023581 ccaagcatgc tcatctgatg tgtggttcac gaccaaatcc atgacgattt tcattccgcg 3023641 tttatggact tcatcaatca gctgaaacat atcttcattt gtcccaaact tttcgtacat 3023701 gtttttgtaa tcgctgatat catatccgtt gtcatcctgc ggggaatcaa ataccgggga 3023761 gagccagatg acatccgccc cgaggttttt gatgtaatcc agcttttgaa tcacaccttg 3023821 caaatctccg aatccatctc cattggcatc ataaaaactg cgcgggtaaa tttgataaac 3023881 gacagcttct ttccaccatt cactcattag gcgttctcct ttcacatcgt ccctgtagga 3023941 caaccggttc ctcataaacg ttcatgtgca gcggctcgcc ttttacaagc tcaaaaataa 3024001 cgcgcttttc gtcaaccgtc acattgatta atcgatttcg ataattgatg ttgaatgaat 3024061 attcgtccca ttctttcggc aaaaacggag caaatgacag cgtctcattc gcggtgcgca 3024121 tgcctgcaaa gccatgaacg attgccagcc agctacccgt cattgaagta atatgcaagc 3024181 cttcttccgt atcatgattg taattatcaa gatcaagcct tgctgtgcgc ttatataatt 3024241 cgagcgcttt cttttccagc ttgagttcgg ctgcgagaat cgcatggaca gagggcgata 3024301 ggcttgattc atgaacagtc atcggctcat aaaattcaaa atttcgccgt ttttcttcca 3024361 ttgtaaaacg gtcattaaaa agataaatgc cttggagaac atctgcctgc ttaataaaat 3024421 tggagcggag aatcttgtcc catgaccaat tctggtaaag aggccgttcc gctggatcta 3024481 attcgtcaac tgtttgcagg tctttgtcca agaacgtgtc atgctgaacg aaaatttgca 3024541 gttcttcact aaatggatag tacatgtgct ggatgatttc tctccagact tccaattcta 3024601 cttcctgcac atccagatgg cggcgtttct ccgctgagat actttcgaga ctttgtagag 3024661 tatactccaa cgtccaagcc gcaatgacat tcgtatacca attgttgtta acgttgtttt 3024721 cgtattcatt cggccctgtg acgccatgga tcatatactt attttttcgt ttcgagaagt 3024781 gaacacggtc ggcccaaaat ctgctgactg ccacaagtac gtctatcccg tattcttcca 3024841 tatagttacg gtcgcctgta taattgatat aattgtagat cgcataacag atcgcgccat 3024901 tgcggtgaat ttcttcaaag gtgatttccc attcgttgtg gcattcatca cctgtgaacg 3024961 tcaccatcgg ataaagtgcc cccttcatcc ccaattttgc agcgtttcgt ttggcagcct 3025021 ccaactgatg atagcgatac aaaagcaggt ttttcgtcac ctccggctcg gctgtcgcca 3025081 aatacatcgg aacggcgtac gcctcagtat cccaatatgc ggcacctcca tatttctcgc 3025141 cagtaaatcc tttcggcccg atattcaaac gggcatcgcc cccgtaatat gtcgagaata 3025201 actgaaagat attgtagcgg attccttgtt gaagctcctc atctccttta atctcaatgt 3025261 ccgcttttgc ccatctttcc ttccatcgat cagtgtgcct ccgttttgca tcttcatagc 3025321 cgttctctac cacatccgcc aaaagctcct tggctttcga taaaagctct tcctcccgaa 3025381 aatcacggga agtcgtgaca atcacaaact ttttcaatga tgccttcgtt tgataactgt 3025441 agcgattctc gacatacatt tcagtcgttt taaagctttc atggacaaaa ccctccgtct 3025501 cgtttgccat tgcggctaat accgtgaagc gcggtgttcc aaatggattt tcgatcgttt 3025561 ttgccgctaa atggccgctg tgagaatcag cacctttcgc ttcctcctgc caaaactgtt 3025621 cttggtagtt agaatcttca tttgccacat ttccatccag gtaaggaaca agcgtaatga 3025681 cagcatctcc cgtcaagcac tccgcttcat aatgaatcgc acagagttct tttacagcaa 3025741 ggctaagaaa ccgctctgac ctgattctga cggttttatc ttgaatgcgg acaacagcgc 3025801 ttcgccgcag aatcccctct ttcatattga gttctacctc aaataattcg attgggtttt 3025861 gatggagatc gattttttca ccgtcaacat ataggcctat gcccataaag ttcatcgcat 3025921 tgatcacttt tccgaaatat tctggatacc cgtttttcca ccagcctact cgcgttttgt 3025981 cggggaacca cacgcctgca atatatgtgc cttggtgact gtcgcctgaa tagccttctt 3026041 caaaattccc tctgaccccc atatagccat tggcaagaga cgtcaggctt tccagcagcc 3026101 gtgtatgctc cttattaaat gtatttgttt tgattttcca ttcatcaatc tcaaataacc 3026161 gctgatttat catcatttcc tcccgaatgt aagtttccat tatcacggcg ggttttggtc 3026221 aaatatctaa atgcaaaaga gatcatcaaa gtaacgccac acgaatggat catcaataca 3026281 gtaatcaaat caaaatgaac catgccgata gcagctgccg caaatgccgg cagtgctgat 3026341 gcgcaaatcg ctatagaggc cgcttccttg aatgatgcaa tagagaccat gtttgatatt 3026401 tttgtgatcc agaggccacc tgcaagaaca aacgttaaca aaagctggat catagaaacc 3026461 accgtatatg ccagcatcat gatcatcggc ttatactgtg ccaaccacaa tgtatcgatc 3026521 aagacctcta catcatggac gtttggtttc tcgagcttaa cgtccatttt cgcatagcca 3026581 acagaaaacc ccgtttcgtt ttgatcggtg atcaccagtt gatcaggttg aaatatgatg 3026641 gcgttttcaa atccagttac tttcaatcgc ccattttcac cgcttgtctc atattcatgc 3026701 ttcatatcga ctgccatcac attctgccca tcttcaatcc tctcagagct cttcccgcct 3026761 gttagttttc cgttcctgat ttgaaaaccc tgcaattgat cagcaaattg atcattaact 3026821 ccttgaatcg ctgacggcat gaaagatgaa acgctgaagc gatccatttt cacaaacgaa 3026881 accgctaacg gcgccattaa gcaggccgtt aaaaacagaa agagaaaaga gagctgcagc 3026941 cagctgaagg tattcccata gcggcaaaca cctgatgggg atgcagccgc cttcaggcag 3027001 cggatgataa agcttttatt ctccagattc ttcattggca ttaccccttt gttccgccgg 3027061 ctgtcaaacc ggacacaaag ttcttttgga gaaaaaagaa tagaacgcat atcggcagtg 3027121 cggctagtat ggcaccggct gcaaatagag ctactttttg ctgctgcgga ttagaaataa 3027181 aggattgtaa tcctacagcg atggtcagcc tttccggtga gcgaagcaga aatttcgtca 3027241 gcaaatagtc gccaaacggt gccataaacg cccaaagcgc ttgtaccgcg agcattggct 3027301 taacaagcgg tagaacaatt gaagcgaaaa tcctcagatg tcccgctccg tcaattcgcg 3027361 cggcttcatc aatttctctc ggcacagtat caaaataacc tttcatcagc cacgtgttca 3027421 tcggaattcc gccgccgata tagatcgctg ttaaaaacca gtattgatcg agtgcgccta 3027481 ttagcatcgc caagacataa aaagcagtca gcgccgccat tgtcggcacc atttgaatga 3027541 ttaaaaagaa tatcaggctc ttttttctgc ctgcaaaccg atagcggctg tacgagtacc 3027601 cggcaagtgt cacaatcgta acctgcaaaa ccatgaccga tagcgcgatg acaagtgtat 3027661 tgctgtacca attgagataa agcgtttcgt caaatagccg cttaaaatga tccaatgtcc 3027721 aagaacccga aaaatcgagc tgaaaagccg ccgaattccc cacacggaag gctgatgatg 3027781 ccgtaatcag caacggatat ataatgacaa tacttaaaag cgtcaaaaat aaatacgtac 3027841 agattttatt aagcattctg gcagtgctcg cgttcaccta cataacctcc tcattgccaa 3027901 aagcattcga ttttttgaaa gcaatcagtg aaattccaat gacaatgaaa gaaattaaca 3027961 gtgtcacagc cgccgcaacg gaatattggg gtgatgtgcc tgttgtcagt ttataaatcc 3028021 acgaaattaa gatatcggtc gatccggccc cggctcccgc actgcctggc cctccctcat 3028081 taaataaata gatgatcgag aaattattga aattaaacgt atactgagta atcatcacgg 3028141 gtgctgtggc aaataaaatc atcgggaatg taatatgccg aaaacgctga ataaaagtgg 3028201 ccccgtcaat ctttgccgct tcatacaatt cacctggaat cgcctgaagc actcccgtta 3028261 ccatgacata tatatatgga aagccgagcc acgtttgaat cataatgagg gctgtctttg 3028321 tccagaaagg atcggtcttc cacgcgatcg caggcagctc gacaaacggc aggtgattga 3028381 ataatggtat cacctgtgca ttcaccgctc ctatgctgtc gttaaacatg ttggaaaaac 3028441 tcatgattgt aataaacgcc ggaacagccc atggaaataa gaaaatcatt cgaaatatcc 3028501 gcttgccttt tataaaatcc tgattgacga aaagtgccgt cacaatacct aaaatgattt 3028561 gcagcgttgt tgcacagatt gtccagataa ccgtccagcc cagtacattc acaaatgttt 3028621 cacgatagga gccaaggaaa aaaatattta agaaattttt aaacccgacc cagtcaatca 3028681 gacgattagg cggaatatga taaaaatcat agtttgttaa tgcaacaaac agagtcacca 3028741 aaaccggaaa aataatcaca aacaccatca tgatatatgc cggcagtgta aatagatacg 3028801 gaaaaccttt atcgcccgca tgacagatca tatccttggc tgttgtattg acttccaaac 3028861 ccgccgcttt catagcggcg gtcttacgtg aatcatgaat attaaagata tagaacatga 3028921 ggaaaatcat tgtcacgatc aattgcagcg tgccttcaat cagcataaac agcgagtgat 3028981 cttcaccggg aacacttccc aatgtcatca atccggttag cgcctgtata ccgaaaacgc 3029041 ataattcaaa agcaaacaag cctgtgatgg caagaaataa gagccccttt gacaactgct 3029101 gattcgcaat ctgcccaagt cctggaatga tcgataaaag ccctgccttt cgtttttgct 3029161 ttgtaagtgt gtgatgttta ttcatttttc cgccctctat tcttccggac gctatcccgc 3029221 cgttttattt cacatacttt tctttaatat tttcctttat gacgtttaca gcatcattcg 3029281 ctgatgtttg tgtcgatttt tttcctgaag ctgcatcaaa aattaaactt tccgctcctg 3029341 tccatacttc agccatttcc ggaatatttg gagtcggcgt tgctgtttca tattgtttaa 3029401 tcacagctga cgtcagttca ttcttttgct catcggcttt cttccttgca gccgtgttgg 3029461 ccggaacttc gtttgtatcc tcataaaaag cgtaagcatt ggcatcattt gcagcatact 3029521 caagccattt ttcagccagc tcgggctctt ttgtatattt cgaggcaacc cagcccttcc 3029581 cgccagcaaa aggggcgtat tcttctccat ttggcaatgt cggaatggga gccgctccgt 3029641 agttcaattt agcctcttta tagttggcag ctgaccaagg accgccaatg atcgcagccg 3029701 ctttgccttc taaaaacatc tgctgaataa agtcgtctgc gcttgaattg tcttgcattc 3029761 ctttcggcca atatgtctca aaccatttct ccgcatattt caccgcttct acagcccctt 3029821 tattgttcag gccgatgtcc ccggaatctg tgccgttttt tccaaacaca tatccgccgt 3029881 atccagccaa taagccgtac gacatataaa agtcagtcca ttttgctaaa aatccggttg 3029941 attttccttt ttccgaagca aacgcgaatc gaggatcttc cgttaacttt tcaaggtctt 3030001 taaatgtttt tggcgctgtt tttaaaagat ctttgttgta atacaaaata agtgtctcaa 3030061 tgactagcgg cattccgtac actttgccgt caactgtcac ctgctgcatt tctttatcac 3030121 caaagctttt tgtgttagat ggcttaatat caagtaaatg tccttgttgt cccaaaccgc 3030181 cgatccggtc atatgcagca agcataacat caggcgcatt acccgccggg ccatcaagag 3030241 gaagcgcttc taactgttcg aacatttgct tttcaacaat ttttactgtg acatcatttt 3030301 ctttttcgaa ctttgttttt atgctttcaa tgtattcttt atacgtttct tcgacagaca 3030361 cagtcagcac ctttttgcca tcagagcttg ctggattttt tgaacttgag caggcggcaa 3030421 ggccgattgc caggaatgat gccgccaata tggcgaaccc cttttttaaa agaaccatct 3030481 cttttcctcc ttctatttac gaaactataa caattgtatt gtcctataga aagcggttac 3030541 aacaactttc gatttgttac cgataacaga atgttataca ggggcggcag cactcaaaat 3030601 caaaaattct cccggctgaa cggcaatgac atcgtgatgc tgtagcggct gctctgtcca 3030661 tgcatcacag attttcttat tcctatcaat attcaactct cgtaaactga cgtgttgaac 3030721 cacattccct tgattaaaga aataaatcag tattttttca tcaagagtcc gcgaaaagct 3030781 aatgaaatca tttttgtcgt ccagcagatt ccactcaaga tgtccttcag tcaataaagt 3030841 gttttcctgc ttgcgtaaag caattaaccg tttcataaat tgcagcatgt cttggttttg 3030901 cttctctttt tcccaaacca tacatttccg gcataatgga tcattttcgc cgttcagccc 3030961 gatttccgtt ccgtaataaa tgcatggtga gcctgtctgg gcaaacataa aggccagcaa 3031021 cgcgcgtgct ttcttctcat cattgcggca tctggtcaaa aggcgctttg tatcatggct 3031081 atccagtaaa ttaaacatca cctcattggc ctgcttcatt ccattcatca aatgtgcatt 3031141 gacacggtga gccatacgtg aagctgagat cgtctggtca gcaaagtatt caatcatagg 3031201 ctctgtaaaa gggtaattca tcgccgcatg aaattcatcc cctctaagcc agggttcggc 3031261 agaatgccag atctcaccta aaatataaac atcaggcttt tcagtagata cagcctgcct 3031321 aaatgtcttc caaaaaacgt gatccacttc atttgcgaca tccaaacgcc agccgtcaat 3031381 gtcaaattcg cgaatccagt acaaagcaat atcaagcaaa tatttctgca cctcgggatt 3031441 agccgtgttt agcttcggca tatcagctgt aaaagcaaat ctgtcataat tgtcgtctgt 3031501 gacgggaaaa gagtgaatat ggaaccagtc cttatagcgg gattgatctc cgtttttgac 3031561 gacatcctgc cattgcggag acgcgcttcc tatatggtta aaaaccgcat caagcataat 3031621 tctcatcccc cgctgatgca gctggctgac caatgtacga aaaagctcag gatccccgaa 3031681 atgcggatca atagaaaagt aatccagcgt gtcgtattta tgattagaag gcgcggaaaa 3031741 gatcggtgtc agataaatgc cgttcacccc taaatcctct aaataatcaa gcttgtcaac 3031801 aattccttgt aaatcccctc caaaaaaatc attgacgtcc gggtccttgc tcccccacgg 3031861 caatgcattc ttcggtgaca agtcttctct tccatttgca aaacgctccg gaaaaatttg 3031921 ataccaaacc gttgacttga cccattcagg cgcttgaaat gtatcagcct cgtgaacaaa 3031981 cggaaattta aagtaataat gaatcgtttc cagtgttttt tcgttataag ggcatacacc 3032041 cgaacttccg aaaaagatgt cttcatgatc gtctgttaca acaaacgcat attgtaaacg 3032101 cctaaatggc ggcaccactt cagcaaacca atagtcatgc atttctgtag cagcaatttt 3032161 cctcatcggc tgctcgtttg ccgaccattt gccgtcgttg tactcatagg gatcacccca 3032221 aatgaatcga atgtgatctg catcaccttt tttcgtccga atcttgatat gcacagtccg 3032281 cccatcataa gaataagcat ctgtgctgaa tggctggtga tgaatcgctg catattccat 3032341 catgtttccc cctttgattt ccgttttatt gaagccggct catagtttga aagtatcatg 3032401 atgaaattgt gggaacaatc cttttcaccc tgttaccgat aacagaataa ggcgcttaca 3032461 gcgttgattc tcgtacaatt aactctggtt caaaaaatag acttccttgt gcagcgccgt 3032521 cttcattcat ttttttcagc aacattttcg cacaggcttc ccccatttca acaacaggct 3032581 gtctgaccgt agtcaagcgc ggcgaggaga tgcgatcaag aaacacaccg tcattcccgg 3032641 taaccgcaac gtcttctgga attcgctttc caagggattg cgccgcacga atgacgccga 3032701 gcgcgattcg atcagatgcg cagacaaatg cggcctgatt gtccatggat ttcagcagtt 3032761 ctcttgcaag gcattcactt ttcttagaac tgttgtcgat ccgaaacata ttcgattttt 3032821 taaagctttt attcatcgcc cgtatatacc cctgttctct tgcacgttcg aaaggctcat 3032881 ctaaatcaat gccaaaaaag acaacttccc gctcccccag ccccataaca tggcgggttg 3032941 ccataaaagt gcctttctcg ttattcacat cgataaagtc atagcccatt tcattttgtc 3033001 caaatacgac gagcggcttc tcaaaagctt ttattacacc ttcaaaatcg ttctttctca 3033061 agccggtggc aataatgccg tcacattggc caatattaag agaatttctt gtcacaagct 3033121 ggagagcata gtgattgcga tccagctccc tgctgattcc tgtcagcagg ttcatgtaat 3033181 atggttctgt cgtatccatt tcctcaagta tcaatagttt cacaacctgt gttctgtttt 3033241 gcacgagcgc tctcgccgca taattaggga tgtaattcag ctctttcatc gcagaatgaa 3033301 caagcttttt caattcatcc gtcaccgtct cagggtgatt gatcactcgt gataccgtca 3033361 ttttcgaaac atttgctttt ttcgccacat ctgacaatgt tgccattttc atcccctcct 3033421 tatctgtgct tattatccaa actagtgata aagtcctcta ttactgctaa atatacgatg 3033481 caggccaaag agaaataaaa aagagatttc ccttaaggaa acctcacttt gttaaaaaca 3033541 ctcgattttt catggattca tacgctaggt ggcagactca ttctctccac ttccatcaga 3033601 aaatctcttt tttaaatttc tgtccacttt ttttctaaaa tcggataaga ataattttgc 3033661 atttgctcaa ttaactcatc cggccgtgac gagctgtgaa tcagttttag gtgcgattcg 3033721 ttagaaaacc cttcttgaat gctgtatttc accattttca tcattggttc aaaatatccg 3033781 tttacattgt acagtccaat tggcttttgg tggatgccga tctgtgccca gcacagcact 3033841 tcaaataatt cttcatatgt accgaagccg cccggcatcg agataaagcc gtccgccagc 3033901 tcgctcattt tagcctttcg ttcatgcatc ccgtttactt caatcagctc agtcagattc 3033961 tgatggacaa cctccccgct gaacaaaccg ctcggcatga ccccgattgc agttccgccg 3034021 ttttccataa tcgcgtcagc aatcgtgccc atcaagccta cgcgggagcc cccatagaca 3034081 aggccgattc cctgctcagc catatacacg ccaagctctg ccgcttttct tttatacgct 3034141 tcatttcccc cagggtttga tcccgcaaat acacaaatgg ttttcatctt gtcatctccg 3034201 catctatata tcgtgttaaa cattcaaaaa cacactatat attgtcccat cttcatgtga 3034261 taatatcaat atgaaataca taaagaatgc aggagtgatg aggttgcagc tggctgatgc 3034321 agaaaaatgg atgaaagagt tttacgaaaa aagaggctgg acagaatacg gaccttttat 3034381 tcgcgtcggc tttttaatgg aggaagccgg agaactggcc cgggctgtca gggcgtatga 3034441 aatcggcaga gaccggccgg atgagaaaga atcgtcacgc gctgagcaaa aacaagaatt 3034501 gattgaagaa atgggagatg tcatcggaaa tatcgccatt cttgctgata tgtatggtgt 3034561 ctctttagaa gacgtcatga aggcccacca agaaaaactg acaaaacgat ttgagcatgc 3034621 ataaaaaagc ggccgcgatg gccgcttttt ttaacctgtg atttcatcat ggtgatcaaa 3034681 gaaatgctgc tttcctattt tgtgaaaaag gcctgtttta tgcagtagct ccttcggctg 3034741 cgattgcaat cctacaatca tcagctttcc attgtggcgt ttaattcgat tcataatgtt 3034801 cccaagcacc gcttcagctg acgtatccat atagtgcacc ttattcatga gcagaataag 3034861 ggttttcggt tttttctgta catgctccag caatgacgat tcaagggaat caattgatcc 3034921 gaaaaacagc ggcccttcta tggcatacat gctgacagat ggatcttctc tcttcgccag 3034981 aacaggatgc gtttcctgat tgtggatgcg ggtcgcttcg ctcattcttc tgataaagaa 3035041 cacgaatgca agcagcaatc cggttgccac accgatgatt aagtcaaaca gaaccgtaag 3035101 ggcgaaggtc gccgccaaaa taaaggaatc agcatttttc agtctcagca tgtttgcgac 3035161 ttccttgcgc tcactcatat tccatgcgac caccatgaga atcggtgcca tactggcgag 3035221 cggcacatgg gacgcataag gcgcaaatac aagcaggaca aggagaacga ctacgccgtg 3035281 aacgacgccg gaaactgggg aaaccgctcc gttttttata ttggtcgccg ttctcgcaat 3035341 cgctcctgta gccgggattc cgccaaacag gggcgctgcc atattcgcaa tcccctggcc 3035401 gacaagctcc ttgttgctgt catgctttga gcccttcatg ttatcagcga ccattgcgga 3035461 caaaatcgac tcaagtcctc caagaagcgc gatgacaagc gcagccggaa acagcataac 3035521 cattttatcc aaagtaagct caggaaactg aaattccggc aaatggcggg ggatttctcc 3035581 ataagttgac ccgatcgttg ccatgcggtc agggaaaaag acaaccgcga ccactgtgga 3035641 aataagaagc gccaacaaag cgcccggcac tttaggcatc accttggcgg atacaagcaa 3035701 aatgacgagc ccgatcacag ctgtcaaaat ggcatacacg ttaaaggtgc cgagctgctg 3035761 cacaatttca aacatgttgt gatgaaagtt ctcatgtttt tcaacatttc tcaatccgag 3035821 aaaattagcg atttgttccg taaagatcag cacggcaatt ccggctgtaa aaccgacgat 3035881 aacgggtttg ggcacgaatt tcattatttt tccgagctta aacagcccaa acagtaccag 3035941 catcactcct gccataaacc ccgcaatcag cagattttcc aagccgtact gcatgataat 3036001 gccgaataaa atcgggacaa aggcgcccgt cggaccgcca atctgatatt ttgatcctcc 3036061 aaacaaagaa atacaaatcc ctgctataac aacagtgtat agcccatatt caggctcgac 3036121 tcccgaggca atggcaaacg ccattcctaa aggaattgcc acgacaccta ctacgatacc 3036181 tgcaatcaag tctttctgaa atttctgcaa attgtatccc ttgaatctcc ctgagaatcg 3036241 catattttgt tataacctcc cttatgagtg attgtttata agctcagttt cataaccgtt 3036301 aatgaccaca tcaagttttc ctgtttcagg gtgaatgaca agcccgtgaa ccggcacttt 3036361 tttcggaagc agcggatggt tcttaatcat gttcacactg tgggaaacgc tttcttccac 3036421 gctgtgaaaa ccagtcagcc acgttttcaa atcgagtccg gcactcgtca gcaaattcag 3036481 gcagctatcc tccaccccgc gttcctttgc tttctcaaga atcgaggacg cattcagccc 3036541 tgacattccg cattcatgat ggccgacaat gcatacctct tcagcctgca attcataaat 3036601 cgcgaccagt atgcttcgca tcacgcttcc aaatgggtga gaaacgatgg ctcccgcgtt 3036661 ttttacaatt ttagcatcac cgtttttaag ccccattgct tgcggaagaa gttctgtaag 3036721 ccttgtatcc atacaggtga caatgacgag ctttttcgaa ggaaactttg tcgttttgta 3036781 cggttcatac ttcttctcac tgacaaaccg ctgattgtgt tccaaaattg atgttaaaga 3036841 aaccatttga ttcatctccc atccatatga ttttgcaagc cttcttaccc agcttacagt 3036901 aaggaattat agcataggaa taagccaaga aaaggttttc aaaaaaagac actataattg 3036961 gactgtagaa tcaaaacata aacatttata tctttcaaag ataataaaat ttatatttaa 3037021 tgcatcctat aatccggctg cagttcgtat atcgatgatt tgtctgacaa aaaatatggg 3037081 tgaattctga taattaaaaa acttttttaa gcagatttag ctgttcgatc ttcattttaa 3037141 gttcaaaaga accagaaatt aaaaaaacgc agctatattt ttaacatcta tttattttcg 3037201 atataatgaa ttagacaaca gccataaagg gggagccttg ttgaaaccat ttgtatttat 3037261 cacaaaaccg attcctgaag agattgaagc attcatcggt gaacattgcc gttatgaagt 3037321 atggcaggag gatacgcttc cgagtgacgt gctatttgaa aaattaaaag aagcggaggg 3037381 gcttttaaca tcagggacgt ccggaccgtc aatcaatcgt gagttgctgg aacacgcgcc 3037441 taagctcaaa gtggtcagca accaatcagt aggctacgat aacttcgata tagaagcaat 3037501 gaaagaaaga ggagtcgtcg ggactcatac accttataca ctggatgaca cagttgcaga 3037561 tctggctttt tcactgattc tgtcttccgc cagacgtgtt gccgaactgg accgttttgt 3037621 cagagcagga aaatggggaa ccgtggaaga ggaagcgctt ttcggaattg atgttcatca 3037681 tcaaacgtta ggcattatcg gcatgggcag aattggagaa caagcagcga gacgcgccaa 3037741 atttggtttt gatatggaag tgctttatca taaccgacat cgcaaacaag aaacagaaga 3037801 cagcatcggc gttaagtatg cagagcttga tacattgctg gagcaatctg attttattct 3037861 tctcattacg ccgctgactg atgaaaccta tcacatgata ggagaacgcg aatttaagtt 3037921 gatgaagaat tcagcaattt tcgtcaatat ttcccgggga aagacagttg atgaaaaagc 3037981 actgattcgc gctcttcagg aaggctggat caggggagcc ggcttagatg tatacgaaaa 3038041 agagcctgtc acccaagata atccgctcct gcagctggat aatgtcacgc tgcttcctca 3038101 tatcggttca gcaacagcta aagtgcgctt caacatgtgc aaacaggccg ccgaaaatat 3038161 gctcgcagcg atccaagggc aaacaccgaa aaatcttaca agagaatttc aataaatcaa 3038221 aaatccggtc tgataacaga ccggatttca tattacatac gctgaagaac agcacgctta 3038281 taaatatgac gggtgacgat ataataaaga gcctggaata caaaataaat gaagatgaca 3038341 attacggcct caagaaataa attggaattc agcatattac ttaacgctgc atacgcaaag 3038401 cccgcgtgaa tcgtacctgc gataaatggg atgaagaata aaaatcctat ttgctttcca 3038461 aggatcgagt gaatctcttt gtccgtaacc cctatcctct ttaacgctaa cacctgcact 3038521 cccgtatctt ctatttccgt aaacatccgc aaatacagca tgcttccttg cacgataaaa 3038581 aacagcacgc tgacaaacag accaataaac agcattaatg caactccctg cttcacaatt 3038641 tgataactag gagcacgtgt ttgaaaatca gatgtatgtt ctttcggcac catgttttca 3038701 agcttttcag agacatccac cgtctcctgc caatgctcaa gctcataacc taccattctc 3038761 atctgttcct tcagcggcac atcctgtgac agactgtcaa agctcttttc gctgacaacc 3038821 aataaacggc tgactccatc gacagacatc aatatccctt tgttttgctg ctttttcatg 3038881 acataggaaa gggtttttcc tgacttcata tgaaatgctg ctgtttcccc ttctccaaat 3038941 gtgtctttca ccatcatttg aaaagaaaca ttaataaatg cttcattttc ttgtaaatga 3039001 ataactggga accctttttc ctttgcgact tgattataga ctttttctga aatcagcaaa 3039061 gcttcagctt ccatcttctt atttccatac ggcaagtctg actgaaaagt gacaggaatc 3039121 cctgtggcat ccaccttata cgtgataaca gcatgagctt ttttcaatgt attctcagcc 3039181 gtctcaggct tcatgacctg aaagcgggaa gcatcctttt ccacccagga aacagactga 3039241 ggaatgcttt gctcctcctg cctttgtaaa tcggaataaa acatatagat gacacctgta 3039301 gctgttagta tgaccgctgt aatgacagag gttaaaaaca gcatgcgtgc atgatccttc 3039361 agcctgaata tcatgttgga acgcacaatg atatttgtgc ctttgtagaa gctgtgtttc 3039421 tttcggtaca gcatgcggaa aaatgccaca ctgctttggg taaaaaagaa atacgtgcca 3039481 attaacacta aaatcaaaat tggaaaaacc cgaaacatca tgtcaattgc attggctgtt 3039541 gcagatagat aataaccgct gccaagacat agcaaagaca atacagtgag ccatttcgaa 3039601 taaactggca aacttttcgg ctttttggct gatttaatca gttcaatgat ttccagcttc 3039661 cgaatccgtc ccagtgataa aatgagcagc gtctgaaaca ggatgagaaa gccggcaatt 3039721 gtcatcacaa acgctttcgg cacaatggca aacgaaatcg gcaccttcac gctgagcatc 3039781 catgtcatga tcataaaaaa cagttttgaa aataacaggc ctgctccaat gccggccgca 3039841 atcgccgcaa gagaaataag tgactgctca taataaatca tcttgcgaag ctgctgcttt 3039901 gatgtgccaa acagtgtcag cagcccaaac tctttctttc ttgcctgcaa aaacgctgaa 3039961 ttggaatatg tgatgaaaaa tatacaaaac acaatgatga cgacaagagc tgcgctcaag 3040021 catgttttga caaggcttcc tccatatata ttgtcttcat tgacatcagg atgaaaaata 3040081 aatgatgtga agacaaaaaa caccgaaacg gcaaacacac agcttaaaaa gtaggccaca 3040141 taccgttgca gattcccaag aatgttttta cgggcgatag ttctcaaatt catgaaaatc 3040201 gcctcccaac acactcaagg tatccaatat actttgataa aacacctgcc tgtttgttcc 3040261 tctgtgaatc tctgaaaaga aacgtccgtc tttaataaaa acaatccgtt tacagaaact 3040321 tgctgctgtg gcatcatgcg taaccaacaa aatcgtcgct tccttttcct cattcagctg 3040381 agccagtgtg ttcatcactt gctttgccga ttttgagtcg aggtttcctg tcggttcatc 3040441 ggcaagaatg agcgccggat tgtgaataat cgctctggca caagctgccc gctgctgctg 3040501 tccgcccgac acctcatatg tgcggtgatc gagaatatgc tttatttgca gcgtatccgc 3040561 cagttcatcc aatcgagctt ccatttctct cagctttacc ttatccaatg cgagcggcaa 3040621 gagaatattt tcacgaatcg tcagcgtatc aagcagatta aaatcctgaa agacgaagcc 3040681 gagttctctt ctgcgaaaca aagccagctc ttggtccttt aacgttttcg gctgaatgcc 3040741 gttgatcatc atctcgccct gggtcggctt atcaatggta gccagcaaat tcaaaagcgt 3040801 ggtttttccg cttcccgacg gccccataat cccgacaaat tctccttttg acacactgag 3040861 atcaaaggcg ctgagcgctt ggtatgatat tgttccttta tttgaatagt atgttttcga 3040921 taggttcgtt gtttgcaaca cgttcatgtt ctgctcctcc tttttcttta ttataaaaag 3040981 gaagtcagca tcctcccatc gaactttctt gcaattccgc tccccaatct tacaatgctg 3041041 tcacattcac gagggtgtca cttgaaaaca cgatggtcat cacagtgcca gccccttctt 3041101 ttgattccgc atacagctta tggccgagac ggctgcacac ctgttttgct aaataaaggc 3041161 ccattccagt tgcctctttc atggttcgtc cgttttctcc ggtaaaaaac gcgtcaaaaa 3041221 tccgcggcag atcctgcggc ggtatgccga ttccttcgtc ggcaaccgac aagcgcgtct 3041281 catgtccctg tgtttcaatc cggattgtaa tagggtctcc cacaccttgc tttgaatatt 3041341 ttaaggcgtt gaaaaggatt tgctcaacaa caaaggaaag ccacttttga tcactggaaa 3041401 tctgaacggc atttggcggc acatgtaatg ttggaaaaag gcgccgcttg ataaactgac 3041461 gtttttcctg attgatcagt gaacgaacca tttctgccaa atcaaaggtt tgcggcttta 3041521 catcaaatgc aaattcctcc agccgggccg tttgcagcat catatcaaga ccgtggcgaa 3041581 atctctcatt ctcatcctcc agctcctcta aaaacgtcgg aaaagaggat gaggttccgt 3041641 tttttccttc ctgaatcatt aaggatatga cagataccgg tgttttcata tggtggaccc 3041701 attggttggt gaaggtgtaa tgctgttttt gctgattgat atattgtgag agcctgcttt 3041761 cgtattgctg cccgagtgcg ttgatcatct tcgtccaaag cgcttgctct cctgttcttg 3041821 gctttctggc tttcaaagac tgtccgatgt cattcgaaga agaggcttgt tctgcaagct 3041881 ttttaacata tgtgagaaag gaaaattgcc gaacataatc agcagcaaaa cctgcggcta 3041941 aaagagtacc gggcaaaatc catatgtaca tcatattttc tttggaaggt tctgcgccgc 3042001 tctctacaat gcttaaatac gcaatcagca tggcggaccc tatccctaat aatgaaaata 3042061 gaataatggc taagcggtcg atgagataag tctttaacat tccgcttcat ccttccgatt 3042121 gacttgaaat tgataacctt gtcctctgat tgtggaaatg caatctgtca gtcctgcatt 3042181 ctccagtttt ctccgcagcc gattgacatt gaccgttaac gtattgtcat cgacaaaatc 3042241 aacgtcatcc cataacgcct ccaatagttc atcacgagag acaatttttt tatgctccct 3042301 cacaaaaatc gagagaagct ggaattcttt ttgggaaaac aaaatccgga cgctgttcca 3042361 ttcggcctca ttctgatcag gataaatcgt cagcccgcca agctccacta ttctagattc 3042421 ctgcggcaaa gagggcgaat attcaccata tgtgcggcgc aggacgcttt tgattttggc 3042481 catcactacc tctagatgga acggctttgt gatataatca tcgccgccat tttcaatcgc 3042541 cattacctga ttcagctcat cggtccgtgc cgatataaag ataatcggcg cattggaaat 3042601 ggtacggatt tgcctgcacc aataaaaccc gtcaaaaaaa ggcaggttga tatcaagcag 3042661 cacaagatca ggcttcattt ctgcaaattc caattttata tcattcagct gttcagcaat 3042721 tttcacttca tatccgtatt tttgaagatg accgcccagc aaagaagcaa tccgctcatc 3042781 atcttccaca agcaaaatcc gatacacgtt gatccccctt atatgtacat cacgatgatt 3042841 tttctagaag attccaaaat tattatagca tgtgcggaat agtaaatcgg tctttttctt 3042901 tttgttatga tagaatgata aaggtaaaat tttcataata ggcaggtgtc gtgatgaaga 3042961 aaatcatgct gtttctggca atgacgtcaa ttctttcagc atgtcagccc aactataccg 3043021 ggaaatacat agaaattggg gatacactaa ctgactatac caaagagtgc tttaaagaga 3043081 atgaaattcc ttataaatac gaaaagggaa aactgtatat cccagaagac gcatttgata 3043141 cagcaatcta cacttgttca taagaaaaag cttgcagata acctgcaagc ttttcacgtt 3043201 acaaaaaatg agtatttaat ttctcttcaa atcctgaagg gccgatgtcg cttttttgaa 3043261 tgttaccgcc gttttcataa atcgtaaaat ggcgctctga catgaccatc cttccgctcg 3043321 gcgtcagctt tgaggcaagc agggatttgt taaaaggaga tttttcatga gagtgaatga 3043381 tgtccttcat gttatctaaa tcaccgagat cactctcttc aagggtaaag gcgtacccaa 3043441 tttgccagcc ttctcctttg tccatcagca gaacatagct gcccttttct gtctcttcct 3043501 ttttgattcg gaatgacccg actggtgact gtaccgtttc tccggaaagc ggtatcggct 3043561 ggagcgccag gttgatgccg aagccgatat caacgaggta atcgccgttt tccgcagaca 3043621 gccatacagc agcatgcgtc ccttctagtg cccatccctc ttgatcgcct gcataaaccg 3043681 ttcctcgaat gagcttcaca tgaaacccgg cctcacgcaa gacaaaataa aggaaaccat 3043741 ttagatcgta gcataggccg ccgtgctgat ctttgagcag acgtcgccat agctcttctt 3043801 ttgtgatctt ataattctct tttgcaagta cggcacggtt ttcgaatgga aaacggtatg 3043861 ccattgcttt aagaaaaagg ggaagatcgc cgaagctgac atggtctttc tcccagccga 3043921 ttttctgaaa gcagtctttt agaaagtcac tcatttttat cacctaaact tcttcttgaa 3043981 cgtaagcagc cagcttctcc agcgcctctt gttcatcttc tccctgggca atcaaggtaa 3044041 cctcagtgcc tgtgcttacc gcaaggctca tcagccccat gatgcttttg gcgtttactt 3044101 ttttcccatc cttctcaaga aacacatctg acgtaaaccg gtttgcttct tgtacaaaca 3044161 aagcagcagg acgtgcttgc agtcctgtct ttaatcgaac ttccactttc tgttgaacca 3044221 taagatctcc ccttttcttt acggttattt taaagtgacg gtttgccctg tccgcagctg 3044281 ttctgcgatt tcgtcaagtt ttctcagcct gtgattgatc cctgatttgc tgattttccc 3044341 gcttgctacc atttccccta gctctttcag cgtcacttcc tgataatcaa tccgcagctg 3044401 cgcaatttcc cgaagttttt caggcagcgc ctccaggccg attctttcat cgatgtattt 3044461 aatattttcc acctgtctca gcgatgcgcc gatcgttttg tttaagttgg ctgtttcaca 3044521 attgacgagg cggttgaccg aatttctcat gtcccgaacg attctgacat cctcaaatcg 3044581 cagaagcgaa ttgtgagcgc caattacgtt cagaaactct gtaatctttt cagcctcttt 3044641 taaataggta atatagcctt ttttccgttc aagcgttttg ctgtttaact gaaactcatt 3044701 taacaggtca cataatgaat cgttatgctc cttataaaga gagaagattt ctaaatgata 3044761 cgaggaggtt tccgggttat tgaccgaacc tcctgccaaa aatgctcctc tcatataaga 3044821 acgcttgcag catctctttt tgaccagctc tttcgaaata cttcgttcaa acacaaaatt 3044881 ctccccgagt atttttaaat cctctaagat cgcttttgca ttttctgaaa aacgcacaat 3044941 atagacgtta ttctttttca gccgcatttt ctttctgacc agcagctcga ccgacacatc 3045001 atattgtttt ttcagcaatg tatagatgcg gcgggcaatc gccgcgtttt cggtttgaac 3045061 atcgagtacg agatggcggt ttgtaaatga taaagctcca ttcatccgaa tgagtgcaga 3045121 cagctcggca ttaatgcagc agtccttcac ttccagattc gttaattctt tttttgtttc 3045181 tgatgcaaat gacatatagc cacctcattt caaggcttca ttctttcagt aaatcaacaa 3045241 gaagagaggc cactttatgt gtatcgtgac gtattacgtc atttttatac gttacaattt 3045301 gatctctgat gacttcaagc cccatcgctt tcagctcttc gatatcaaaa tcaacaggac 3045361 gcgccgattc catttcgtac ttacgtttta tttcgtcggg aatgtcttca ctgttcacta 3045421 atatcgtatc aataaaacca cagcccatat gctgattgag cgctttcaca tgatcagcag 3045481 cggtgtaatg gagcgtttcg ccgggctgag tcatcacgtt gcaaatgtat acttttttcg 3045541 ccggcgcctt tatcacttct tccccgattt ttgggacgag caaattggga agaatgctgg 3045601 tatagaggct tcccgggccg ataataatca aatccgcttc cctgattacg tctattgttt 3045661 ccggcagcgg atcaatctgt tcaggcgtga gaaaaacacg cttaatgcgc tgtccgtatt 3045721 ctgggatcgt tgactcgcct gagaccacgc ggccatcttc catctcagca tgcaaaacga 3045781 cactggcatt ggcagccggc aaaacctttc ctcttacatt cagcaccttg ctcatttctg 3045841 tgacagcgtg aaaaaaatca ccggttatat ttgtcatcgc tgccaaaatc aaattcccga 3045901 gagaatggcc tgttaagtca ttccctttat tgaagcggtg ctgaaaaaga tcttcaacaa 3045961 gcggctccac atcggataaa gcggcaagca catttctgat gtctccggga ggcggaattt 3046021 tcagttcatt ccgcagacgg ccagagctcc ccccatcatc ggcaactgtt acaatggccg 3046081 tgatgtcaac gggtttatgc tttaggcccc gaagcaatac agaaagacct gtaccgccgc 3046141 caaagattgc gattttcggc ttttgtccca tcttatttcc ggcttctctt ttcaatgtcc 3046201 cggtgagtaa catgagtata gtaatccttt ttgaaataat cagctaaatt ctcggctaat 3046261 gtcacagagc ggtgctggcc ccctgtgcag ccgatcgcaa tgacaacctg gctttttcct 3046321 tctcttttgt aagatggaag cataaagctc agcagatcaa ttaatttctc attgaacttt 3046381 tgcgtttcat tccacttcat gacgtaagag gaaacctctt tatccttgcc agtcagcggc 3046441 cgcatgcttt cgatatagta cggattcggc aaaaatctga catcaaagac gagatctgca 3046501 tcaattggaa taccgtattt aaaaccaaat gacatcacat ttacggtaaa tgtctctcct 3046561 tggtttgtcg caaagtgctt cacgattttt tcacgcaaat cacgcggctt catgtcagac 3046621 gtatcgtaaa tgatttgaga gcggcctttt aattcctcaa gcagctctcg ttctagcgcg 3046681 atgccttcaa gcggcaggcc agtcgctgcc agcggatgcg agcgtctcgt ttctttatat 3046741 cttgtgacga gaatggaatc cttcgcgtcc aggaataaaa ttcgcggtgt gatccacgga 3046801 ttttcggcca tttcatccag cgcttcaatc agccggtcaa aaaattcgcg gccgcgcaaa 3046861 tccatcacga gcgcaacttt gctcattttc gaatttgatt ccttcatcag ctctaaaaac 3046921 ttcggaagca atgaaggcgg aagattatcg acgcagaaat agccgagatc ttcaaagctt 3046981 tggatcgcga cagttttccc cgctcccgac attccagtta taatgacaag ctgaatatca 3047041 tgtgattcac taacactcat ctttctcccc cctgacttgt ctttctattt gatgtgctgc 3047101 gggtctaaac gataactgag cagctcaaat tccggtgtat acgtaaatgt gccgtgcagc 3047161 agcccttgtc ccttcatcat aaaatcaagg atatggccgt ctccaggggc cataggcagg 3047221 ttctgaatgt cattgacatc gtgccactgc agtttgcctt cctctgattc tgatacattt 3047281 tgtcctgtat atgaatcagc gacaaacgta aacatcatcc actcggagac aatgtggtca 3047341 ccgtctttaa taataaaggt aaaaacgcct tttaattgag gatttatgat atagatacca 3047401 gtctcttctc tgtactctct gatgacggag tctctgactg attctccgct ctccatcttg 3047461 cctcccggcg cgacccacca tccgcgtctc ggcttttgaa gcagaagaac tttgtcatcc 3047521 gtctgaagca cacaatttgt cactctttgc aagtacgtca cctaaccttc gtcctgtcat 3047581 cgtctcttta ttataccgct tcaagatgcc tcccacaatg aagagacatt gacaatcttt 3047641 tcttctattt tacagcatat tcattcctta attcagatga ttttgctgta actggaattc 3047701 tcttttattt atggacaaaa aaaggacacg gataactgga gaatccgtgc caaaaaagtg 3047761 tattcattat aaaaaggggg tcaattactt tattaatcat aaccgaaaag cattacacat 3047821 gtgttacagc ggaattaaaa cccagtaacg taatgtgaaa ctcgtatgac agcccttttt 3047881 attttaaggt tttcagcgtt tcttggagct cttcgacata atgttgtacg ctttgtgccg 3047941 caatgcttcc gtctcctgta gccgttacga tttggcgcag tgatttttcg cggatgtctc 3048001 cggcagcgaa aatcccttca accttagttt ccatgcggtc gtttgtttcg atatagcctt 3048061 cttcattcgt aatgcccagg ttttcaaacg gtttagacag aggaagcatg ccgatgtaaa 3048121 tgaatacgcc gtctgttttg aattcacttt cttcaccggt taccgtatcg acaagcgtta 3048181 cgttaccgac tttgccgttt tcctcatgaa tttccttcac agttttgttc cataggaagt 3048241 caactttttc attatcaaat gctctcgctt gaagaatact ttgagcacgg agtttatcac 3048301 gtctgtgaac aatcgttact tttgaagcga aacgagtcag atatacgcct tcttcaaccg 3048361 cggaatctcc gccgccaaca acgacaagtt ctttgccttt aaagaaagcg ccgtcacata 3048421 ctgcacaata agatacaccg cgtccgccca attctttttc gccaggcacg ccgatttttt 3048481 tatattccgc acctgcagca atgatgacag cacgggcttt atattccttt gaaccagctt 3048541 tgactacttt gtactctttg ccgtcaatga cctctttaat atcgccataa gcgtattcag 3048601 cgccgaattt tttcgcgtgt tcaaacattt tgttagaaag ctcaggccca aggatacttt 3048661 cgaatccagg atagttttct acatcttccg tattggccat ttgtccgcca ggaattcctc 3048721 tttcaatcat taatgtcgat aaattcgctc ttgatgtgta tacagcggcc gtcatcccag 3048781 cagggcccgc gccgattata atcacgtcat aaattttttc ttctgacaca ctattcactc 3048841 cttaaaccat cttttcaagt ttgggctctt tcttataaga taagaatccc catcaaacgt 3048901 attccttacc catatcctat aaaatctcat ggtgatacgc tatttttttg ctcaacacga 3048961 ttaaatgtat tcgaaaaggg tatatgttaa taaagaaaga gccttctgtt tatagaaggc 3049021 ccttgtcata tttattattg aacaacacgt cttacaacac ctttaaatgc tgctttccag 3049081 taaggattgc tcatagagtc aacagatacg ccatgagatg tattgtcgtt taggaaagta 3049141 ccgtttccta agtagattcc tacgtgtcca tttgttttgt aagtgtcaaa gaacacaagg 3049201 tctccgcgtt tcatttcaga cgcgctgaca gcttgtcctc tgccaactaa cgtatcagtt 3049261 gttgttccgc ctacaggtcc aaggttaaca cctgcagaag cgtatgccca gcgtacgaat 3049321 gatgagcagt caaaaatacg gttgttgata tcagactgag tgcgtccgcc gccaaacttg 3049381 tacggagatt gtcctacaat gcttgaacca acgctgatcg cgccttcaat tccgccagag 3049441 ttgctgataa cagtgccgcc tgaattgctg tttgagccgc tgctcttctt agaagatgag 3049501 ccgtttgacg aactgtttga tgaaccgtta gaagaattgt ctgaagaatt gtctgaagaa 3049561 tcatcagatg agcttgcttt tgatgattca gttgtcgccg tttgactgtc atctgtttgt 3049621 gtttcatcag atgctttttg tgcttcttcc tgctttttga tcaaagcagc cgctgcttct 3049681 tgttcttttt tgatgcgtgc ttgttcagct tcagtatttg ctttttgatt tgcaagttca 3049741 gacgcctctg attttaattc agaaatcgct ttagccgttt tcttttggct tgcttttgct 3049801 tcgtcgaaaa gcttgtcttt ttcattaagc tgtttatcaa ggtctttttg cattgtttct 3049861 aatttagcca aggcagcttg aacttctttc agcttgtcat tcaaatccgc ttcagaatct 3049921 tcgagcttcg ctttatcctg ctcttgctgt ttgattaaat ctttgtctgc gtccacaata 3049981 gatgaaaccg cagtcgcacg agagataaag tcaccaaagc ttgttgatcc taaaagaaca 3050041 tctatgtatc cttgagatcc gccgctttcc tgtaaagaac gaacgcgttt tttcaggatt 3050101 tcattgcgtt tttcgatgcg tgcttcagtt tctttaatct cttttttcag ttttttgatt 3050161 tcttcttttg ttttatcgtt ttcttctttt ttatcttcaa tcttgttgct tgtatcaagc 3050221 gccttatcgt taatgtcttt cagttctttt tcaatctttg attgattttc ctgaagctcg 3050281 gttaattctt tttccttcgc ttcaatgctg gaagcaacct cagattgctt gctttcgatt 3050341 ttttgtttct tttcatctaa tgtttccgcc gatgcagttt tacttgtaaa tgggatcaaa 3050401 aaactgcttg tcccgatgac ggaagccaaa ccaagtgtaa ttaaactctt tctcactttt 3050461 tatatcctcc cttttactgt gaacctgtcc tcatttggaa tcgtattttg aacatcaagt 3050521 ttcgttcctc atactctacg aggaatgatg gttgtttatg gttaattatt ctgtgcatct 3050581 cttattctgg ttgtatagcg tttatttcac atcatatgta aaaaacacta attccttatg 3050641 tacgagaatc attataccat caagtttcga caaattagcg ataaatttta ttacatttat 3050701 gtttcaaaca gatgtcaagt cacacatcat ttgtcatttt tcttaagcgt gtaaaaaaac 3050761 tgtcgatatt attttcttaa tataatctat ctaacaaaaa aagagtcgat taaataaatc 3050821 aactctttaa aatttactat tctagaatat catcaatata tttcatatat ttcgtcaaag 3050881 ttgccggaga gatgccgaat cgggccgctg tgtctttttt cgtgtcttgc ttgccatggg 3050941 cttctttcca aatataacag atggctgctg cccagccttt ctcattcttc aacggagcag 3051001 ctgcacgaat ttgctggatg acatgaaaaa cccagcagct catgacttct gttttcatct 3051061 cttctttttc agcttgctct aatagtttga ccgtttgata agcgaaaagt gcatcctctg 3051121 aaacgtcagc agccgcagaa tctccattca gaagcagctt tacaaaatga gtttcaaaag 3051181 gagcggtaat tctctttgag cgtatcaccg cttcaagatg ctctgtttct ccctttgtgc 3051241 tgctgatata ataggctgcg agtcgctgct ccacagatga aggaagagct tccctccgct 3051301 caatccaagg cgccgggcgg tcttcgccgg gatattgcga ctcgactttt ctccagatcg 3051361 tctcggcaaa gtcggtatgt cccgtaaaat aagcagagca ggaaagccag taaaagaagg 3051421 tgtcgtcacc ctcaaagccg gttttatata atgatttgag ccatttatat ccgatctcgt 3051481 agcggccgac aagcgccaaa gtagcaccca atttataacg ctgctccaat agcatcggat 3051541 agacattgga gagctgatca ctcaattccg ccactttttc gtcttctctt tcataatagt 3051601 agaaaacgag aagattgcat aaggcgtgaa gatttccttc attatgagaa agcacttcat 3051661 aagcggtttg cttcgctttt acaacgtttc ctgaatagaa ataggcaagc gcgagattgt 3051721 tgtatgctga ccaaagctcc ggatattcag ttgtgatttc ctcaagcgcc gcaaccgctt 3051781 cagcaagctg gccgctttcc agcaatgact ttgcccgatc ctgtttcacc agcagttcat 3051841 cctgatcata caacgaatcc tcaatgccgt cgtctcctaa atcgagcaaa tcaagcagac 3051901 tatcgttttc ttcggcgaat tcaccatccg ggtccgcatc agaataagcg gccgcttctt 3051961 tataagcttc ctggaagagc cccagatggg caaagttatt cgctttaaag taatggcact 3052021 ccggcatttc ggcctccaga tttgccatga tatagtcaag aagatcgttc gactcttgat 3052081 actggcccat ttccgaataa atgaccgcaa gctgtgaaag catctctgaa tcctccggct 3052141 ccaaatgaac cgcgcgctga atcagtttgc ttgcccgttt tagattgcgc tctttatacg 3052201 ctttcaagcc tttatgaaaa aaatattgtc catcttgaag cagctggaca atttgtgcgt 3052261 gatttttatg ttcagaagtg tgttttccca caactaccct ccgttttata caatattacc 3052321 gtcagtagta taccataaat cgtaagcccc tcaatagttc aaaaggaagg attgggaaaa 3052381 tccctcctct tttttattgg ctgattcgac caaaatttac ccggctttgt tttctaagtc 3052441 cgcattcatt ttcagctgct gttcagcaaa atcccggtaa aggccatggg aagccattaa 3052501 ctcatggtgt gttccacgac cggtaatttc ccctttttca acaaacaaaa gctggtccgc 3052561 atctacaacg gtagataggc ggtgagcgat aacaatcgtt gtgcggccct ccatcagcac 3052621 ctccagcgcc tgctgaactg atttttcaga ttggctgtcg agacttgagg tagcttcatc 3052681 gagcataaga atgcttgggt tacggagaag cgctctcgca atcgcgattc tttgcctttg 3052741 tccgcctgac agcataatgc cgcgttcgcc cacttctgta tcaaactgat tcggcagctc 3052801 ctttataaaa ttgagcgcat atgccatctc cgcggctttt tcgatctcag catccgtcac 3052861 atctcgttct aacccgtagc aaatattttc tctgattgtc ccggacatta acgggctttc 3052921 ctgtgataca tacccgatat gctccctcca cgattcaagc gagtaagtat cgaccggctc 3052981 gtcccccagc cgaatggtcc ctgcagtcgg agaataaaag cgttcaagca gcttaaacag 3053041 cgtcgttttt cccccgccgc tcggaccgac gatcgctgtc actttccctg cttcaatgac 3053101 ggcgctgacc tcttttaaga tcagctgatc aggcttatat ccaaaagaca cgcgatcaag 3053161 ctggataggc agatgtgcat tttcaatttg ttttcctgtc actgtatctt cctcttcctc 3053221 tgccaaaatc tcaatcattc gttctgttgc accgattgat ttttgcagct gtgtgaaaaa 3053281 cgttgtaatc tggcccatcg gcataataat ttgaaacaaa tataaaataa aagccacgag 3053341 cgctccggct gtgagctcgc ctgatgagac ctgcatgccg ccatatccga tcactgcgac 3053401 aagcgctgcc attaacacga gtgaaataag cgggccgaca agcgattgaa ccttggcttc 3053461 acgaacgcca agcttaaata atgaggaaat ccccatcttc ccgcgcccat attcgacatc 3053521 ctccgcattt gaagccttaa caagtctgat ttccgggaga atttgattaa gcaggcctgt 3053581 aaaacgagcc gtttcatctt gcgtttcccg tgaaatggag aacattttcc gtccaatcgg 3053641 caccaaaata agagcggcca gcggaacgac cactaacaca agcagtgtca gcttccagtt 3053701 cataataaac aagattgtca atgatccaat gacagaaatg atgcctgtaa taaatccgct 3053761 gatatgggtt gtaatcaatt ctttgaccac catcgtatcg ttcgttacac ggctgactgt 3053821 ttctccggaa gcatttgtat cgaaataaga gacaggcagc ttaattaatt tcttccataa 3053881 taactcccgc agcccggaaa tgattttttg tccattatag ttaagcgcat aggtggcata 3053941 agcgcttaaa cccgcctgaa cgaaaaacac cagcgcgatc aaaccgattt gcgtgcctga 3054001 cagatttgac atagaaaaac catcgacaag ctgcttcgtt aataatggaa tgagcaggct 3054061 gaccagcgtg gttactacac tgagggcaag cgcaaaggcg agctttccat aagaaggatt 3054121 ggtccgtctt actaaggcaa aaaagggttt caatttactt ttagattttt gtttcttggt 3054181 tggcatatat tttcctcctg tttcagcgtt cagaaaggtg aaaagtcata gcaaaaggat 3054241 gatttttact ctttctcaat catatcaatg gagaaagact ttttcagtat atttttgccg 3054301 tgatcaaaat aaaaatctcc cactcattgt ttgaatagga gatttttgtg ttagacatct 3054361 ttcactggct tcttttttct gtaagtcaat gttacatcct gctgtcgcag gtcttctatt 3054421 atcattttgt accgatcaac ttttgcggta tgttcttctt ttatcatctg aagggcagct 3054481 tttcgttttt cgctattaga ctcaagctct ttttttattt tttttacaat caaccctttt 3054541 tgccctttga tttcctcttt taatgaagac tcaaatttct ttgtcaggct gagaaagtcg 3054601 ttgatcggtt gattgagggt gcccgctttc cccttcattt catcttgggt aagaaacata 3054661 taggtcgttg atacaatttc tgtttcactt tctgaaaata aggaagtcac tcttcatatt 3054721 cctcctaaga ctgaaaatca aataactgag aaatcatttc ttctttttca aacagctttt 3054781 caatactctc gcggatattt ttgataaaat ctcttttttc tgttgtctgt ttttttaatt 3054841 cagcaacaat tccatcattt gcaggaagcg cacctgtgtg gaatgattca tgaactgaga 3054901 ttttctccaa tttatcgaat gtgtggctga aaccagctgc aagccggaat tgaagatcga 3054961 aggcataatg cgaagggttt tcttccatat gatgaatagc cgtgatgatc gcctgctttt 3055021 tgtctatgaa gtcttcatcg atttcctgac tgtaaacctt ctggtactta gaaatcgcat 3055081 cttccatatc ttcaacgatt ttcataccgt tttgatagat tctgacagcg gatgagagat 3055141 tgacttgaat cgtttctccc gagccactct tccctgtaaa ataaatatcg gagcctttat 3055201 agctgaagcc tttttccttt gacaaggcgt tgagcatttg aacgatgctg tggccgtcga 3055261 cgataagttt tagtgcgtct tttgtttctg tgtcgagtgt tttcaatgag gacagaattg 3055321 attttacata gtccactatt tcaccaacgt cttttaaagc ttgcataaat tggccatgtt 3055381 ttagatggtc tatgaaatgt tcgtaccgtg actctatgcc tcgcatactc gcattaatat 3055441 tcgttaattc ttttttgatg actttctttt gcgtttcatc aatataacca ttttcagcta 3055501 actgatctac gaccggtccg ctgtttctca acaaggtatg aagaaaacct aaaaacgacg 3055561 gcagttcctc ttttattcgg ccatacattt gcttaacatc atcaaaatgc tcatatagga 3055621 cacttacttt ctttaaagcg ccgtctgtgt ttttcacttt ttcaatcagg tctatgtcta 3055681 tcccgctggc tgcctttata aaaccgttca agccgtcttt ttcatagtca tccttatatt 3055741 tttgaaggaa tttttgaatt gacctcacat cttcgtcagg aaccccatcc ataatgtttc 3055801 ggatgccttt tacacttgta tttgtatctg ccatcttcac atcaccgaat gtaataaaat 3055861 cggccttgcc gctgactcca tacagcgggt catcttttga gatgcgctga gtgatgtttg 3055921 ttgttacgcc tttgtcttca taatattttt ggatttcttt ttttaacttt tctggcggga 3055981 tggaatctat atcttcatat ttataactaa atttcctaat aacatatcta tataaacttt 3056041 catcagtttc aagtaattga tcaatattga cttgagctcc atttacccca taaacttcat 3056101 catattctcc atcaatcaat tgcaccataa cttggttatt atttgcaagt gaatgtccta 3056161 aggcgaatgt ttttaaatcc tcagagttac ctgctgcttt ctttgctttg ttagtaaact 3056221 cctttgtagc ctcatactga ctatgatcaa ttcctaaaaa aagaccaaaa aagttatatg 3056281 accaatcctt attatcggca ctaccttctg aaataatctg aagctgatca atatgttttt 3056341 tctcatctat tatatggatt gccgttccat cgtaacctga ttctctggtc gaactttgta 3056401 tacttgtatt ctgatttaca agttcattgg aggtgtaaat ttcaattttc atattctcag 3056461 gaagatcgtg gtgggtttcc tctttataaa ttctgcgtat atctgcttcg aaatccttct 3056521 tagctttctt aacttcactc gcaatagttg aggcaaactt ttgtttatag tcatattcta 3056581 aatcaattaa ccttaacttt acgttctcat tctcaaatac atttttattt cccatcttat 3056641 ttctcctttt tatctattaa aaaggtgata gaattaatta atttctcaac tttattttta 3056701 gccttttctt catctaagga gcatggttga ttttcatttt tgcatccaag ggtaaaggcg 3056761 tattctactc ctaggttatc ttcctctgta gacttaacat atccaaaata actgtatgaa 3056821 taattatatt ttctatcaat atcgtcaaag atgtcttttt tcttggcagt gtaaatatcc 3056881 gttttctttt tgctgctttt tttgtattcg cctttataat cattttttcc actaacaata 3056941 tctagcattg tcttaggttc attcgcaaaa ctttcttctt tgtaatatgt tacatggcca 3057001 tcaaacatta cattggtgtc tttatcataa ctattaaatc caatactttc tttgtttttc 3057061 ccggttaacg atgatcttct tgatagatac tttccatcct ccggaaacaa catcctaaac 3057121 cctttcagct tagattccag caaataatat cctggttcct cttcttttgt tgacaccatg 3057181 tactctctcg ttttctcgtc ctgaaacgca ggtacttgag gcagatcctt gggatccatg 3057241 tcttttggtt ttaccgcttc tgttttattg tcatttgtgc tgtttttatc attgtcattc 3057301 atactgcatc ctcctgtcag ggcaagtaat aagctgaagc aaataaagat gatctttttc 3057361 attacgaacc tccacgggtt ttgtgagaat agtattctat ttttatatca aaaataattc 3057421 tattgacctg gttaagagat gattatttca tcctttttca tgttacatca tggcggaatt 3057481 tggataaata ggaaatgaga ctcggttttg atctcctttt attaactaat catatataac 3057541 acccaatata aatctaaata cctattactt ttttcacaaa acaaaaagag ccgtatcatc 3057601 cggctcttta ctcttcaatc tcagaatggc gttttttcaa tacgtcaagc acatcatcca 3057661 gcggcaggga ttgttctctg agcaggacaa gcaggtgata cagcaggtct gccgcttccc 3057721 atttgagttc ctcatgatcc cggtttttcg cggcgatgat gacttcggat gcttcttctc 3057781 cgactttttt caaaatctta tcgacgcctt cacggaagag gtacgtggtg taagctcctt 3057841 caggcatttc cgcttggcgt tccgcgatca cccgctccag ttcgttcatg atgccgaatc 3057901 ggtccgcggc ctgttcttct gtttgttcct ttgtaaaaca gctgtagctg ccagtgtggc 3057961 atgccgggcc tgacggttct acgagtacga gcagcgcgtc ttgatcgcag tcataccgga 3058021 tacctttgac ggcttgcgtg ttccctgagg tttctccttt atgccataac gcttggcgtg 3058081 agcggctgta aaaccatgtt tccttcgttt ccagcgtttt ttcgtacgat tccttgttca 3058141 tatacgcaag tgtcagcact tctttgcttg ccgcatcctg cacgatagca ggaattaatc 3058201 cgtcctcgtt aaaacgcagt tcatctgcct gtttcatctc acattcaccc cgtactcttt 3058261 caagtatgat ttcacttctt taatcgatgt ttctttataa tgaaaaattg aggcggccag 3058321 cgcggcgtcg gcttctcctt ttgtaaaagc ctcaagcata tgctgtgcgt ttcccgcgcc 3058381 tcccgaagcg ataacaggga cggggacagc ttcggaaaca agctttgtca gcgtgtggtc 3058441 gaaacctttt ttctcaccgt cggagtccat gcttgtcagc aatatttctc ctgccccgcg 3058501 tttgacgcct tcttttgccc acgcggtgac ctcccaatct gttttctttc tgccgccgtg 3058561 cgtgtagacc ttatatgtgt cagattcttt gtcatacttg gcatcaatgg caagtacgat 3058621 gcattgagaa ccgaaaaact cggctccttc tgtaatcagc tcagggcgga gaacagctgc 3058681 cgtgttcacc gacactttgt ccgctccggc acgcagtatc gttttcatat cgctgagctg 3058741 attgatgccg ccgccgactg taaacggaat ggcaagcttc gcggcaacct gctccacaac 3058801 gtcaaccatc gtctttcgtc cttcgtgcga ggcggagata tcaagaaaaa caagttcatc 3058861 cgcaccttcc cggtcgtaca cttcggcgag ttcaactggg tcaccggcat ccttcaattc 3058921 gagaaattga attcctttga caacgcgtcc ttctttgaca tcaaggcatg ggataatccg 3058981 ttttgtgatc atttgcgctt caccctttca agcgcctcac tcagcgtaaa ctgattggta 3059041 tacagcgctt ttccgatgat cgctccagag acgccgtccg cctcattgcg ggcgagagct 3059101 tcgagatccg cgacggagct gactccgccg gaagcgatca ccgatttccc cgtttcctta 3059161 gcaagctcga ccgtgctttt aacattgggg cctgacagca ttccatctgt cgcgatgtca 3059221 gtaaaaataa agacttccgc accttcattg gctagctctt tgcccagttc agttgcctta 3059281 agggttgatg tttcaagcca tccctctgtt gaaacaaaac cgtttctcgc atccagtccg 3059341 attgcaattt tctcgccata ttgtttcagc atttttttga caaacggagg gttagaaact 3059401 gctgagcttc ccaggatcac ccgctcgact cctgctgata aatattcata gacgtcattt 3059461 tcagaacgga tcccaccgcc gatttcgact ttcaggttca gcttttgcgc aatctcaatc 3059521 acatggcggt cattcactct tttcccttct ttggccccgt cgagatcaac gagatggatc 3059581 cattcggcac cctctttctc aaataactca gccatgtcgt acggtgaatc gccatatatc 3059641 gtttccttat tataatcccc ttgaacaagg cgaacacatt tgccgtttct catatcaatt 3059701 gccggatata atgtaaaagc actcattttt tcaccttctg ttctgctgcc attttcgtaa 3059761 attgggttaa aatagacatt ccgaccgtgc tgcttttttc cggatgaaat tgggcgccga 3059821 agacgtttct ttttccgact acagcaggca ctcgtacacc ataatcggcg cttgccagaa 3059881 gcgcgttctc ctccatcccg tcaatgtaat aggaatgaac gaagtaagcg tagccttgtt 3059941 ctgttttagt cagcagcgga gattcattat gaaaagaaag acgattccag cccatatgcg 3060001 gaaccttcag cttgtttcct ttttcatctt ctgctttcag cctgactgct tttcctttta 3060061 acagcccgag tcctgaagcg gtgccgtttt cttcgctttc ttcaaataaa agctgcatgc 3060121 cgaggcagat cccgagaagc agccttccct ctgagaccat atcgtgaatc aattgatcaa 3060181 gcttcgtgta gcccaaattg tccatcgcgt ctccaaatga accgactccc ggcaaaatga 3060241 aagcatcagc ttctttcagc tcctccggct tttcagaaac aaaatacggc acgccgacac 3060301 gttcaagcgc ctttgagaca ctgtataaat tccccattcc gtaatctatc acgccgatca 3060361 tttacagcat ccctttcgtt gacggtattc ctttaactcg cggatcgatc gttgtcgctt 3060421 catcaagcgc acgtcccagt gctttaaaaa cggcttcaat catgtggtgg gtatttgttc 3060481 cataatgaac gatgacgtgc aggttcattc gagcttcgag cgccagcttc cacaaaaatt 3060541 catgtacaag ctccgtatcg aaagttccga ctttagcagc cgggaaatca gcgcgcattt 3060601 ctaagtgcgg ccggttgctt aaatcaatca caacttgagc aagtgcctca tccatcggca 3060661 caaacgccga tccgtagcgt ttgattcctt ttttatcgcc caacgcttcg agcagcgcct 3060721 gccctaagca gatgccgata tcttcagtcg tgtggtgatc atctatatca acatcgcctt 3060781 ttgcgttaat ggaaagatca aattggccgt gtttcgtgaa taaatccaac atatgtgtca 3060841 taaacggcac atctgtttta atatccgctt gtcctccgcc gtctattgta aatgccagct 3060901 caatatctgt ttcgtttgtt ttcctgacgc gttccgcttt tctcatttag aaatcctccg 3060961 ttctctcgct tcaattgatc tggcatgggc ttctaaccct tccagtctgg caaaagccgc 3061021 gatgctttcg gcatgttctt caaaggctga ttgactgtaa gaaataatgc tcgatttctt 3061081 ttgaaaatca gttacgttta atggacttga aaatctggct gttccgtttg tcggaagcac 3061141 atggttcggt ccggcaaaat aatcaccgac aggctcaggg ctgtatctgc ctaagaaaat 3061201 tgcacccgca tgtttgatac tgccaagcaa agcttccgga gactgtgtta tgatttctaa 3061261 atgctctggc gcgagtgtat tgacagtctc aatcgcttct accattgttt ccgccacata 3061321 tatacaaccg taatctctca ctgaagcttc cgctatttct cttcgcggca aggtttccag 3061381 ctgcttattc acctcggctg aaaccgtctc ggccagcgcc atggaatctg tgacaaacac 3061441 acatgagcta agcttatcgt gttccgcctg tgacagcaga tcggctgcaa tttcgctcgg 3061501 aatcgctgtt tcatcagcca gcacgacgat ttcactcggt ccggcaatca tatcgatatc 3061561 gacatcgccg aacacttctc gtttggcaag cgcgacataa atgttgcccg gacccgtgat 3061621 tttatccacc ggctcaatgg tttctgttcc gtatgctaac gccgcaatcg cctgagcgcc 3061681 gcccattttg taaatgtctt ttatgcccag ctcggctgca gcaaccaaaa ctccaggaga 3061741 cagcagaccg tcttttcccg gaggcgtgac gagaacgatt ctttcaacgc ccgctacgag 3061801 cgccggaatc acattcatca aaacagatga aggatatgcg gccgttcccc ccggcacata 3061861 tacaccggcg gaatccagcg ccgtcacttt ctgccccagc attgtgccgt cctttctgtg 3061921 ataaaaccag gaggattgca gctgtctttc gtgatattcc ctaatatttt cgattgcctg 3061981 cctaatcacc tgaagaagac gtgaatccag tgaggtgtat gcctcctcaa attcttcttt 3062041 tgtgaccagc gggctgtcta tttcgatgca gtcaaatttc gccgtgtagc tgcgaaccgc 3062101 ctgatcaccg tttgctttaa catcttcaat aatggaccgg accgtctttc tttgctcttc 3062161 cgttccggca tcgatggaac gcttgagaga aagccgttcc gctccgctga tggttttgat 3062221 cttcattttg ccgtctctcc ttccacaacg agagataggc gggatgccat ttcgtcaatc 3062281 acatcgtctt tcatgcgata gcttaccggg ttgacaataa agcgagaggt aatgtcacaa 3062341 atgtgctccg tttcaacaag cccattttct ttcagcgtct gtcctgtgga aacaatgtcc 3062401 actatccgat ctgcaagccc aatgagcgga gccagttcaa ttgaaccgtt gagcttaata 3062461 atctcgactt gttctccctg ctctctgaaa taactggaag ccacattcgg atactttgtc 3062521 gcgattcttg gcgctactcc gctccagtct gtattcggaa gtccggcgac agctaagtgg 3062581 catttgctga tgtttaaatc cagtacctca tacacatcgc gttcctcctc cagcatgaca 3062641 tccttgcccg caattccgac gtctgccacg ccatgctcca catacgtggt tacgtccatc 3062701 ggcttcgcta atataaaccg aagattttcc tccggcacat cgatgatcag ttttctcgaa 3062761 tcttcaaact cctcagggag cctgtagcct gcctgcctca gcagccctgc cgcttcttca 3062821 aatatccggc cctttggcat cgccattgtg agtaacttac ccattttgct cttcctttct 3062881 ggcaccgata aaataagtga cgtttgcaaa agattttgtc atctggtcga tattttctat 3062941 tcccgataaa tcttgaagaa ccactttgtt ccctttcatg cgttcttcat tcgcataagc 3063001 gatggcttgc gcccgctgct ctttgctgaa aataacagcg tctatttcac aaggttcgtc 3063061 cttcatatga agggcttcaa tcagccggtc gatccgaagc ccgaagcctg ttgccggtgc 3063121 aggtgaatca aaatggccca gcagcttgtt gtaacggccg ccgcttccaa tgacaaaacc 3063181 gacattctcg gcgtacactt caaataaaat ccctgtgtaa tagctcatgt ggctgaccat 3063241 attcagatcc aggcggacat tttccgtaca tccgtaatcc tcaagaatgt cccacagcgc 3063301 cttcagctca tcaaccacgc tttttccttg cgcagaatcg acgatttcct cggcacgtcc 3063361 gcatacttct ataccgcccc gcagttcaag gagctcaagc agcctgcttt tatcaatgga 3063421 ggaaagcggg agagacttga catgctctct gtagccgacg tagttctttt catataagaa 3063481 cctccgcagc acatcagctc gttcaacgtt tccgagcacc tcaacaaaca aagcatccgc 3063541 aatgccggca tggccaattg caattttaaa ggatgccagc ccagcgtttt ttaatgcccc 3063601 gacgactaaa gcaatgacct ccgcatccgc gctcgtcgtg ccgtcaccga ttaactccac 3063661 tccgacctgc tcgaactcag ccggacgtcc gccttcacgc tcctgagccc tgaatacatt 3063721 tgccgcatag ccgactctta gcggatgacc gtgtttcaga agcttcgatg ccgccaccct 3063781 tgcaatcggc cccgtcatat ccgggcgaag caccaatgtc ttgccgtcct gatcaagtag 3063841 cttaaacagc tgctgctctt caattgctga ctggacgcca acggtatcgt aaaactccag 3063901 tgtcggcgtt tccataaatt gatatcccca tttatcaatc aaatcggtta acgatcgtct 3063961 cacctttttt ttcgtttcgt ataaaccggg cagtgtatct ctcatgccgt gcggtttttc 3064021 aaacataaac atcaacccga gcacctccgc tgttatctta tgaaggaaaa ttccgaatcc 3064081 tttagttcgc taatatgata atatgttagc agatgaaaga atgaaaatca acgcttaact 3064141 tcagtaagga tatttttagt tcaaatatcc ttctcctcat tatgaaaaaa tcatgaataa 3064201 tgtattaaag gtacgtaata tctcaaattc tttatgtttg gcatgctata atacaaatca 3064261 aatagagaac aaggagataa agatgaaaac actgcgaact ctatgtgtcc tgatgattct 3064321 ttcaggcgtt atttttttcg gacttaaaat agatgcaaaa gatatagata ttcctttttt 3064381 gaacagcctt aaaaaagtgg tttctgatag cgatacagac tcagctgcga atagcaaaaa 3064441 ggagctgaag ggaagcgcaa aaccgctgga tgtcatcctt tacaatcaaa tggacgcacc 3064501 ccggctctat aacggctgtg aagtaacaag ccttgcgatg gtgctgaatt atgcgggata 3064561 cgacgtgaca aaaaataccc tggcaaatca ggttgccaca gtgcctttga catacagcag 3064621 cggattaaag ggtgatccga atgacggatt tgtcggggat atggcgaatg gccctggtct 3064681 cggtgtctac catcgaccga tctatcagct ggcgaaaacc tatgcgggag acaaagtgtc 3064741 tgatctgact ggaaaaagta tttccgctgt ttatcagcag cttgaaaaag gcaatccagt 3064801 ttgggttatt acgacagcca actttacgcc agttgacaac atgcagacat ggaaaacgcc 3064861 aaacggaacg atagaaatta cgtacagcga acacagcgtc gccgttacgg gatatgatga 3064921 taaatatgtg tatctcaatg atccgtatgg ctataaaaac agaaaaaccg atagaacaag 3064981 ctttgaaaaa gcgtggaaac aaatgggcag ccaggccgtg gttattcaaa agtaaacacc 3065041 tgaagcctca ctatgctcta ttctgagcaa atacgacaat attcatgctt tttgtatcaa 3065101 tcggtaagat cgattcattt tccatttttc acccaaaatt gtctttactt tcaggctgtc 3065161 tgtttttatg attaaagcag attcagcctt gccccgatct atgcgagaga agccggtgca 3065221 agtcgctgac gcttctcttg caaaaaatga aagatatccg gggaggattt atcattgaaa 3065281 aaaatcgtgt ctatcctatt tatgttcggt ttggttatgg gtttcagcca gtttcagcca 3065341 tcaaccgttt ttgcagctga caaagtggtg cacgaaacaa ttatcgtacc aaaaaataca 3065401 acatatgacg ggaaaggaca gcggtttgtg gcagggaaag aattaggtga cggaagccag 3065461 tcagaaaacc aagaccctgt ttttcgtgtg gaggatggag caaccctgaa aaatgtggtg 3065521 cttggtgcac ctgcagctga tggcgtgcac acttatggaa acgttaacat tcagaatgtg 3065581 aaatgggaag atgttggtga ggatgcgtta acggtgaaga aggaaggaaa agtgacgatc 3065641 gacggcggtt ctgctcaaaa agcgtcagat aagatattcc aaatcaataa agccagtacc 3065701 ttcacagtga aaaatttcac ggcggataat ggcgggaagt tcattagaca gcttggtggt 3065761 tcaaccttcc acgttgatgt gatcatcgac aagtgcacca tcacaaacat gaaggaagcg 3065821 atattccgga cggacagcaa aacaagcacg gtcagaatga caaatacacg ctactctaat 3065881 gtcggtcaaa aatggattgg tgttcagcat atttacgaaa acaacaacac tcaattttaa 3065941 caaaaaaagt ccgctgatgt tattcagcgg actttttcaa tctttcttgc atttcttcct 3066001 tcgtatagat gatcctcatc ggatttccgc cgacaaatgc cccgtcaggc acatccttat 3066061 ggacaagcgt tccggcggac acaactgcgc catctcctat tttcaccccg ggcagaatgg 3066121 tcgtgttggc accaatcatc acttcgtccc cgatcagaac tttgccgatc cggtattcgt 3066181 gaatcaaata ctcatgggcc agaatggtcg tattgtaccc gatgattgta tttgttccga 3066241 ctgagatctt ttccggaaac atgatatctg gcatcaccat gagggcaaag gatgtctgtt 3066301 ttccaacctt catccgcaga aatgtgcggt acagccagtt tttcatccct ataaacggcg 3066361 tatatctcgc aatttgaatg acaatgaaat ttttgacgac ctttaaaaaa ggtaccgttt 3066421 gatagacatg ccacagtgag ttggcccccg agaccggatg acgatctgtt tttctcacag 3066481 attacttcac tccaacgatt tgtaatagat cactcatttt ctcaagcata aaatccggct 3066541 catgcttcgc cagcatttcc ggccctttaa tcgtccatgc gactcctgcc gtttttgtac 3066601 cggcgttttt ccctgccagc acatcatggt aattatcacc gaccataatg gcttccgccg 3066661 gctcgcttcc tagctgtttc agcgctaaca gcacaggctc gggatcaggc tttgcattcg 3066721 tcacatcatc aagggtgaca actgtttcaa agaattcgcc gattcccgtg agcttgaggc 3066781 ccatattgac agtatctctt aattttgttg tcacaattcc taatgtaaag ccggcttttt 3066841 ttaatgcatc cagggtctca tataccgttt catattcagt gacgagtgaa tcatgcatgt 3066901 catgattgta cgctctgtac atagcgatca tatcctcgca tttatcaggg tccatcgaag 3066961 agaacgtatc aaaaagagac ggcccgataa atgcaaggac atcttctcgt ttatacttgc 3067021 tcggataata atgctccagt gtatgcaaaa aggacgcgat aattaattca ttcgtattaa 3067081 taagcgttcc gtctaaatca aacagaatcg tcgttacttg tttgtcactc atattgcttc 3067141 ctttccaacc gctgagggtt tccatttttt ccacgtgtgc gcaatagcca ttgtcagcag 3067201 aactgctgtg gtgacacgaa tcaaaagaag cggccagacc ggtatgccaa gcggaataaa 3067261 gacaagtgta tcttccacga ccgcgtggca ggcaacgaga aatataaatg ccaatgtcat 3067321 gtcccgcttg ctcacgccgt catcctcgac agctttgatc atgacacccg ctccgtaggc 3067381 cagaccaatc gtcagtcccg tcaccatcgt catagacgta tttttattca tgccaagcag 3067441 ctgcgtaaac ggcgacagcc acctggaaaa ccgataaagc cagcctaaat ctcttaaaaa 3067501 ctggatgata atcatcagcg ggatcactat tgccgccagc tgcaaaacac caagtccggc 3067561 tttcgttaat gcttctgcca acattcctag ccagctgtct ggcgccgcgc tcttcgcagc 3067621 gataaaaccg tactgcgccg tttcctttcc gccatgccaa atgaggttga tgacgatggc 3067681 tgacacagcg gccaaaccga tgcgcacggc caatatgacg ccaattctga taccaacctt 3067741 tgcggcaact gtcgattcga taatcaagtt atgacagaaa gaaagcataa cagctaaaat 3067801 aaagacttct ttcacagata aatccaatgt taaaatcccg gcaattcccg catacagatt 3067861 cagcatattt cccagtacaa gcggaatggc cgcttcacca gaaagcccga agagacccat 3067921 taccggtgtg atcagccgta caagccaatc catgacaggg gtatgctgga gcaaagtgac 3067981 caatagcgtt accgggaaaa tcactttacc cagcgtccat gttgtttgaa aacctgctgc 3068041 aagaccggcc agaaagatct tcttcatccc tcatccccct ttgttgacgt ctactccgcg 3068101 taccgctcct tcgagtatcc cttgacgcgt ctgaagatga tggctgccac agccaaaaca 3068161 atcaatacga ttgaaatcac ctgagcgatg cgaagtgaat cagtcagcat taagctgtca 3068221 gtccgcattc cttcaataaa gtatcttccg attgaatacc aaatgatata gatcaagaac 3068281 atctcgcctc tacgcaaatt cgctctgcgc agcagcagta aaacaatgac gccgacaaag 3068341 ctccatagtg attcatataa aaaagtagga tgataatatt gcccattgat atacatttga 3068401 ttgatgataa attcaggcag gtgcaggttt tctaaaaagg ctctgctgac agcctcgccg 3068461 tgcgcttcct gattcatgaa gttcccccag cggccgatcg cctggccgag caaaatgctg 3068521 ggcgcggcaa tatccgcaag cttccagaac gaaaggtttt tcactctcga aaacacataa 3068581 cccgttaaaa tggcgccgat taatccgcca tgaatggcaa tgccgccctt ccaaatctta 3068641 atgatttctc ccggatgtgc cgcataatag tcccattcaa aggcaacata ataaattcgt 3068701 gcgcaaataa tcgcaattgg aatggcaaac aggacaagat caataaacgt atctttctgc 3068761 agcccccgtt tttcactttc cctcatcgct atccacagcc cgagcaaagc gccgagaccg 3068821 ataatgattc cgtaccagtg gacggctaac ggccccagct gaaatgctat cggattgagt 3068881 ggttctatcg cttcattcat ttaacgccaa ctcctattct tcttgttcac cgtcttcaat 3068941 gacgtccgcc agcttgttgg taaattgttc agcggcattc agccccatcc gcttcaatct 3069001 gaagttcatt gctgccactt cgatgatgac tgcaagattt cggcctgggc ggacgggaat 3069061 cgtcagtttt gtaatttctg tatcaatgat tttcatggtc tcttcctcaa gtccgagccg 3069121 gtcgtattgc ttgccctgct cccagagttc aagattcatg acaatcgtga ttcgtttatt 3069181 gcttctgacc gcgccagcgc caaatagcgt catcacattg ataatgccaa ggcccctgat 3069241 ctcaagaagg tgctcaatta attccggagc gtttcccaca agagtatcct gatcctcctg 3069301 ccgtatttca acgcaatcat cggcaacaag gcgatgccct cttttcacaa gctctagcgc 3069361 tgtttcgctt tttccgacgc cgctttttcc tgtgatcagc acgccgacac catatatatc 3069421 gacaagaacg ccatgaattg ctgtggtagg cgccagcctg ctctcaagga agttggttaa 3069481 acggcttgac agtcttgtcg ttttcagcgg cgatctgagg acaggcaccc catttttctc 3069541 ggaggcgtca atcagctcct gcgggatggg catatctcta gaaagaataa tagctggtgt 3069601 tacatcagtg cacagagaat ccattcgctg ctttttctcc tcttcaggaa gctgttcaaa 3069661 gaaagaaagc tctgtttttc cgagaagctg cacgcgctcc ctcgggtaat atgtaaaata 3069721 tccggcaatt tcaatacctg gtcttgatag gtcactcatt gtaatcgggc ggttaattcc 3069781 ttcttctccg ctgattaatt ccaaattgaa ctgttccatt acgtcttttg tgcgaacctt 3069841 tgccacgata tgttcctcct gttccgggct gccccgagct tgctcacaat actttcattt 3069901 tatcactttc gggcttgaac ctaaaacaga ttttataaaa ggggggaaaa cacctcagct 3069961 ggtctagatc actagtctga aaaagagtaa aataaaggta ttcaaattcc agaaaggcgg 3070021 atcatctatg gcagagagtc ttcttatcaa agacattgcg atcgtgacag aaaatgaagt 3070081 aatcaaaaac ggctatgtcg gaatcaatga cggaaaaatc agcacagttt caacagaacg 3070141 gcccaaggag ccatattcaa aagagattca agcacctgcg gattccgttt tgcttcccgg 3070201 catgattgac attcatatcc acggcggcta tggcgcagat acaatggatg ctagcttttc 3070261 cacgctcgac atcatgtcgt caagactgcc cgaagaaggc acgacgagct ttttagccac 3070321 aacgattacc caagagcatg ggaacatttc tcaagctttg gtgaacgcaa gagagtggaa 3070381 agcggctgaa gagtcctctt tattaggtgc agaactgctc ggcattcatt tagagggccc 3070441 ctttgtttcg cctaaaagag ccggagcgca gccaaaggag tggattaggc cttcggatgt 3070501 tgagcttttc aaaaagtggc agcaggaggc gggcggactg atcaaaattg ttacacttgc 3070561 gccggaggag gatcagcatt ttgaactgat ccgccatttg aaagacgaat cgattatcgc 3070621 atccatgggg cacacggatg ccgattccgc attgctgtcg gatgccgcaa aagcaggggc 3070681 gagccatatg actcatctgt acaacgcgat gagcccgttt catcaccgag agcccggagt 3070741 gatcggaacg gcgctggccc atgatgggtt tgtgacagag cttatcgccg atggcattca 3070801 ctcccatcct ttagctgcaa agcttgcttt tttggcgaaa ggcagcagca agctcatttt 3070861 aattaccgat tccatgaggg caaaaggact gaaagacggc gtatatgagt tcggcggcca 3070921 aagtgtgacg gtaagaggac gaacagcact tctttcagac ggaacccttg ccggttcgat 3070981 cctcaaaatg aacgaaggcg cacggcatat gcgtgagttt acaaattgct cttggacgga 3071041 tatagctaat ataacttctg aaaacgcggc caaacagctg ggcatctttg accgaaaagg 3071101 cagtgtgact gtgggaaaag atgcagattt ggtgattgtc agcagtgatt gcgaggtgat 3071161 tctcaccatt tgccgcggaa acattgcatt tatatccaag gaggctgacc agatatgaaa 3071221 gtaatggaat gtcaaacgta tgaagagcta agccaaatag cagccagaat aacggcagat 3071281 acaatcaaag aaaaacctga tgctgttctc ggtttagcga cgggcggcac accggaaggc 3071341 acgtatcgcc agctgatccg cctgcaccaa actgagaatc tctcatttca aaacatcact 3071401 acagttaatt tggatgagta cgccggactt tcaagcgatg acccgaacag ctatcacttc 3071461 tatatgaacg accgtttttt tcagcatatc gacagcaagc ctagccggca ttttattccg 3071521 aatggaaatg cagacgattt ggaggccgaa tgcagacggt atgaacagct agtcgattcc 3071581 ctcggcgaca ctgacattca gcttctcggc atcggccgaa acggacacat cggctttaac 3071641 gaaccgggaa cgtctttcaa gtcgcgaact catgttgtga cattaaatga gcaaacccgc 3071701 caagcgaatg ccagatattt tccctccata gacagcgtgc cgaaaaaagc actgacaatg 3071761 ggaattcaaa cgatactctc aagcaagcgc attctgctgc ttatttctgg aaaaagcaaa 3071821 gcggaagctg ttcgtaagct gttagaagga aacataagcg aagattttcc cgcatctgct 3071881 ttgcacctgc attccgatgt tacggttttg attgatcgtg aagccgcgtc attaagacct 3071941 tgaaaggaac atgctgactt atgaatatca ataaacaatc gcctattccg atttactatc 3072001 agattatgga gcaattaaaa acccaaatta agaacggaga gctgcagccg gatatgcctc 3072061 ttccttctga gcgcgaatat gccgaacaat tcgggatcag ccggatgaca gttcgccagg 3072121 cgctttctaa tttagttaat gaaggcttgc tctatcgcct gaaagggcgg ggcacctttg 3072181 tcagcaagcc aaaaatggaa caagcacttc aagggctgac aagctttacc gaggatatga 3072241 aaagccgcgg gatgacaccg ggcagcaggc tcattgatta tcagcttatt gattcaactg 3072301 aggagctcgc ggctatatta ggctgcgggc acccctcctc tatccataaa atcactcggg 3072361 tgcggctggc aaatgatatt ccgatggcga ttgagtcctc acatattccg tttgagcttg 3072421 cgggtgaatt gaacgaatcg cattttcagt cgtcgatcta tgatcatatt gaaaggtaca 3072481 acagcatacc gatttcccgt gcaaaacagg agcttgagcc aagcgctgcc accacggaag 3072541 aagcgaatat tcttggtatt caaaagggag cgcctgtcct attaattaaa cgaacaacat 3072601 atctgcagaa cggaactgct tttgagcatg caaaatccgt atacagaggc gaccgttata 3072661 catttgtcca ctatatggat cgtctttcat aaaaaaagcc tccaaccctt tttaaggatt 3072721 ggagacatgg cgaaaatcaa actggtctgg tgccggacga tatgtttctt ttttcgtctt 3072781 gaacttccag atcggtgatt tcgttttgcc gttaaaactg tcttccacta taatgtacca 3072841 ataataaaca gactgcggtt caagatgatc ccagcggaat tcagctgtgt ccccgctctt 3072901 cacttgctcc cgttttccga gctcttcatt ggtatatacg ttacattcaa aataatcggt 3072961 ttccaccttt ttgattcttg gcttcaaatc aagcgaaagg gaaaattcat ccttgttgcc 3073021 ataggtatcc gtatcatagt agttcttatc ctttacatac ggagagtacg tcgatacgtg 3073081 caccatgtca ttggcttggt caaattgaag caaacgcaaa tacccttggc cgccttctgg 3073141 cccgccctga taatcggcca gcatttgatg cacaagacga tccggtttcc catcaccatc 3073201 atcatccagc tcatctgttt ttctcatcgc actatgataa tgcccgctca acaccatcac 3073261 gacattcggg ttcggcttta cgatttcttt gaatattttc tctccgattg ggcttctgtt 3073321 tccgctgacc agcaaatact catgaaaagc taaaatggcc atccggtcag gatgcttctt 3073381 cagcacctga ttcatccacg cgatgtcttc atccgtaatg ccccatccca tgtacagcat 3073441 gatataatca ttgccgttgc tagaaatcag gtcataatgt ccgcggttat ttttatagga 3073501 accgccataa tgaaattttt tatcaaaacg atcgctgcca aaatatttgc caaacgccct 3073561 gtaggagccg tccttatgtc cgacatcgtg attgccggcc agcacgccgt aaggaattcc 3073621 gctcttatcc agaacggaca ttgaccgatc agcgtttttc cactgtctga tatcggcgga 3073681 atcatctaca atatcacccg tgtggaacac atatttgata ttgagctgct tttgattatc 3073741 ttttatccat tcggtctgtt tatcaaaaat atgcggatag ctttcggcgt aatactgtgt 3073801 atcagacatc cagacaaatg tgtacatatc cttcgcagga ggaatttcat cctgtacaat 3073861 cacattcatt ttcgactccc gtacaaaatc ggcggcaatc acagacgctt tcagcgtaaa 3073921 cggtttgtca tccttcgcga cgaagctgtc aacaggctgc cattcgtttg tccgataatt 3073981 ccaagcatac atcgtcacct ttctccccgg caaagaactg cccttccaga ctgattctgc 3074041 cagatcattc tcatcaattg atggatcaac cgtcacttca aagcgatgat aagggaaaag 3074101 ctctttgttt tctgtcgata ctgtttttcc atcagcagct gatacccgct ccaattcttt 3074161 attcgtaaat ggggtctccc tttccggcac aaagcttttc ggcggttcag tcagtgacgc 3074221 gtgcttaaat attttcacat gattgcgcgc tgtatattga aatcccctat aaaaaccaac 3074281 atccatggca tcattcgtcg gatctttcac ccgtacagaa agcttggcct tatgcgtgtc 3074341 ggcttcgctg tctataacct ccggctggtc cggatgctct cgttcggttt taaatatcct 3074401 ctcaatcact gttttattgc ccgcgagatc cgttgctgtc acttttagag aatgttttcc 3074461 cggcaaaagg tcagaagatg acgtatgata tgggagtgta atgctttctc catctaacga 3074521 cgcctccgct tcctcaattc tgctccattt atcatacata tccgcctgca ggataaggtt 3074581 tcctttatac gtttgcccct cggtgatatt cggctcaatg tgaggtcctg aattatctac 3074641 ccgtacaacc aggctgacat tttccttccc gtcgcttgct tgaatatggt gagcgccttc 3074701 agaaagcttt gatgtatccc actccagcag ctgtgatgta aatagtccgt caggcagatt 3074761 gaactgaaat tgccagcttt tattcgagcg ctgattatcg ccaataaaga gttccttctc 3074821 aggagacacc ctctgatctc tgatcaccgt tccatccgat aacaccaatc gggcgttttt 3074881 gactaagaag tcatcacggt tttcagccgt atcaaacgga gacaccttcg aacctgaacg 3074941 tatcgtaata cgctgcagct gcttcccttt ccgaagcagt gtctctggca atggaacaga 3075001 ataggtgcgg tatttatttg ttgtatcatc gaacaccttc agcactttgc cttccatcgt 3075061 taccgcgttt ttaaaataaa ggttcgtttt cctcgtatcg aatgcaaaat atacttcttt 3075121 ttccatcgcg ggctctgtca cttgtttttt cccgtcaatc catagcttaa tgctgtcagc 3075181 tcgcccttct gtcgtggctt tgagaaattg agttcccgac agcgtgtctc tgttttcaat 3075241 attcatccgc agaccgtgcg ccttgcttgt ttgtttaata tcaatcattt tgaccggcgt 3075301 tctcgcttca ttgatcccgt ccccggccgc cacataatac tctagctgat ccttcccgat 3075361 caattcaggc gaatacacaa tataatggaa gagattatcg ttgcggtctt tttcagcaag 3075421 aattcgctta aacggtttgt tctcatccgt ccggtagtaa aaggccactg ttttcactag 3075481 gcttcggtcc cgtatgtcag cccgcagctc aatgctttca gcagggcgga caggcttgcg 3075541 gtcagtcaaa tcctcaatga ccggcttttc tttatcgagc ttgattttcc gtttctggtc 3075601 gggcacctgt gcctgtaata cggttccggg agacggattc ttttccccga ttgaaatgtt 3075661 cagaagttct gctgttccgt tcagtggata cttataaagc actgatgaca gccggcgcag 3075721 cgcatgtttc cgataatgcg caaccgaaat gtcctttcct gtattcgttg atatcacaac 3075781 ggcccgcggc ctcgtattgg ccataccctc tgtctcgtct atcaccgcaa gattttttcc 3075841 ttcttttagt tgtgtctgat aataacgatt gaaatccgct gacgtcaatt ctggatgccc 3075901 ggcaggcttc agccagacga caaacgtttc gccggatggt atcaagatcc tttcatcagg 3075961 tctccaaatc agatcggagt caggcccttc ttttgggtag cggtaacgga tatggtagtc 3076021 tttaaaatca atcgttctgt cagtcgtatt aaaaatctca ataaattcat aaccgtctgc 3076081 gcgtcctata ttcttcgtat caaccgccag ctctgtgatc agaagctccg gaatatgggc 3076141 aaggtcagcc tggtatcctt caagcttcag tttcttcgtc tccgactcaa cccgctgctt 3076201 cccattcgac atcacaatgt aatactcaag ctcgctgttc caaatcaaac gtttcggaat 3076261 ttgtgccaaa aacttgcgga ccgctccggg ggtcgggtcc atcggcacca ttttgtagcc 3076321 cagctcatta ctttgtttat aaaaaagaaa ggcggaaaat gcttgatacg aattatcgcg 3076381 aacttgagcc tcaatcatta gattgcttct catttcagct ttcacatcaa tttgaggagg 3076441 attttcaagc aagggtatgt aatgaggcgt ttgaaatagt tcctgctgta caacaggaaa 3076501 agctttcgat tcatgatggc cgccagacaa aacggaaaga aaagacagta atatagaagc 3076561 aataaccgtg tatttcctca tcaaagcacc tcccttttca tgtattttgc gtctgaacag 3076621 ggaagcttat gagttcattt ttgtgcataa agaacaaaaa aacgtctgtc tcttgaaaat 3076681 tccactatta cccagtaaac taaggatagt taaccagtta acaattaaat cagagaggca 3076741 aattgatgga caacagcatt catgatgaat tatttcaagc tatacaacaa ttcgcattaa 3076801 aaagggataa acgcgtctgg caaaaggtgc agataccatc cattggcata tcctcacaac 3076861 atcacgatca cctcaaaaaa gactggactt tgacccagct tcacattgtt tcctgcatac 3076921 ataccagcca aaatgtgaac aacagcttct tagcatcccg tttacacatc tcaaaagccg 3076981 ctgtttcaaa agcggttcat gctttgttga aacacaatat cattacagtg acaaaaaagc 3077041 ctggcaacaa aaaagaaatt ttttatacgc taactgatag cggcagaaaa ttggcggcat 3077101 tacatgaaca gcttcatgag aaagcaaagg agcaatataa acagcttttc aatgaatttt 3077161 caattgatga tttaaaaaca gtgactgcgt ttttcaactt gtggatcaaa tatatgtaaa 3077221 aagagtctca cccgcatggg agagaccttt ggaattctat tatgccccgt caaacgcaac 3077281 gagaagtgaa acaggtccgc gtgtatacag accggactca gcataacaaa aatcttcctc 3077341 taatctgata ttccgcatct tatccagcac aatattagct acaatttcga tttcgttttt 3077401 ggcaaaagct gctcctacac agttatgaat gccggatccg aaagcgagat gccgggcggc 3077461 gccgctaaaa gcgctcttga taccaagatc ttcccgatga atattaaaca cgtcaggctg 3077521 ttcaaatgct tcagggtccc ggttagccgc accgatcata caaaaaacaa tcgtatcttt 3077581 tttgatttcc ataccgccga ccactgtatc ttgggacagc tgccgcggaa tcagctgaac 3077641 cggcggttta taacgcaatg tctccgcaat ggctctcgga actaacgaac ggtcagccaa 3077701 aacatcattc atctgctcag gattgttgag caaatggtag atcatcagtg ccagcgtctt 3077761 atcagccggt tccgttgcgg ctaacagcac attaagaatc agtgcgagta tatccttgtc 3077821 cgacagcgcc atgccttcat attcagaagt acataggatc gaaattaaat ctgatcccgg 3077881 attgacgcga cgttctttaa tgaccggcat caagtattgg gaaagctgtt cgctgcacca 3077941 taacgaatgt gcccgcgctt caggagattg agagatactc gtgataaaat cggcaactcc 3078001 gctgtgccac tcagagattt tttcatggtc tcttttatcc agcccgagca tgtccatcgt 3078061 gacgcacacc gcaaacgtct ttccaaaatc attgacgaga tcacttttcc ctctttcaag 3078121 ataaggcgct aacaagtttt ctgcattttg tttaatcaat ggagacagat gatccagtgc 3078181 gtcaccgata aagcttctca ctacaattct tcttttggca gagtgttctt ttccatgcat 3078241 ttgggccagc acagggcctc gcatgactgg ttcggcacgc tcaacaagtg atttcgtcgt 3078301 gaagatatcc ggatgctgaa ggatatagcg gacatcatga tagcggctga taaaataact 3078361 gtctatcgac tcttcataat gaaccggatc ttcctcccgc agttgtgaaa aataagcata 3078421 tggattgttt tgaaattgat cagaaagcac actaaacaat ttaatcgatt ggctcatgtt 3078481 ttactccccc tatcatcctt cagatgtgat ccgtttctca gaaagcatct gcgccatttc 3078541 ctgtacaatg agataccctt gattcggccg catacaaata gaaaattcat ggttactgat 3078601 cttctcaccc agcttccacg gacgatgata agcaaggagt gtctcttcca cctctaaaat 3078661 atccggagct ccgataaaaa acggcagctc agctatgaca tattccacag ccaaattcag 3078721 catatcctca ctgacttctt ccatcatcaa actgacgccc cgcgcacgcc cgattatcgc 3078781 ttcacgagac atgtccaaac aagcatgtcg aaaatgaggc tgctcaaaaa atgcatgttc 3078841 aacttcttgt ctcaacagct ggtaggcttt gttatctata aaatcagaaa atgtatgaat 3078901 cgccttcgga tccccgccat gagccacaag ggctctttct gcaaatctcc tgtttcgtga 3078961 tacctctttc cttacttttc gttcagcctt tcctctcgga gttccaagcg cttctagaag 3079021 attagccgcc tcatgccctg caagtaaaac tgaaacgctt ttaaattgag ctttcgccca 3079081 tccaattaat ctgtaaatat aatcctctga aaacctgctg ttaaatgggc tgatccccac 3079141 caaaacatgc ctgcgccgtt caaatatttc tctgcagttt tctgttaatg cctcagcaat 3079201 aaaatgcaca gaccttcttt ccgttaccat tccggtcatc tcattcaccc ctaaaactta 3079261 tcccgcttta agtcatcacc ctcaaataca agatggaata gctagaacaa ctgaacaaga 3079321 cgaatggcag gcatcactta aagtttccaa atgtttttta agattttaat aatcattttc 3079381 aatacccata tcatgataaa tgtttactag taaacattag tcattttatc ccttttcctt 3079441 ccaaacgtca atatgatctg tgcccaaata tttgaaaata aatgtaaaca tcacattttc 3079501 cacacacttt ttacacgcat attcagcatg acatatcaac aaatagtcta aacaccaaca 3079561 attgacaacg aaaacaagaa aagataaaat aaaattgttc accagtaaac gatttgtttt 3079621 attgtttcat cgtaaactat tattcctaag aaagaaggta gcctatgtct gatttgacaa 3079681 aacagatgat atacgacata tacgtgagac tgctgcacct taatgaacaa aaagcgaaca 3079741 cttcacttca gcaatttttt aaggaggccg cagaagagga tgtagctgaa attcccaaaa 3079801 atatgacaag cattcacgtc attgactgca tcggccagca tgaacccatt aataatgccg 3079861 gaattgccag aaaaatgaac ttatcgaaag cgaatgtaac gaaaatcagc acaaaactga 3079921 tcaaggaaga attcattaac agctatcagc tgacagataa caaaaaagaa gtttatttta 3079981 aattaacccg taaaggcaga cggattttcg acttacatga gaaactgcat aaaaaaaagg 3080041 agctggcttt ttaccaattc ctcgattcat tttcacaaga agaacaaaag gctgtattga 3080101 agtttctaga gcagttgacg tcaacacttg aagcagaaca aaccgatggg actccagaca 3080161 aacctgtaaa gtaaacaaaa aggcggtgta cactttggct catacaaaat caaaggcagt 3080221 attgatctta tacactgttt gcttcagtgc attttttgca tctttaagcc agaacattta 3080281 ttcacctatt cttccgatca ttaaagaatc attccatgtt tccacagcta tggtgaacct 3080341 gtcagtctca gtttttatga ttgtgacagc aataatgcaa attatattag gagcgatcat 3080401 tgattttaaa ggcgctcgga tcgtcttgat taccggtatt ctggcaacgg cagcagccag 3080461 catcggctgt gcggtgacta ctgactttac cttgtttctg atattcagaa tgatacaggc 3080521 agccggttcc gcagcactgc ctcttattgc tgccacaacg atcggacagc tgtttacagg 3080581 aaatgaacgc gggagtgcaa tgggaacgta tcaaatgctc ctgtctgtcg caccggctat 3080641 tgctccagtt ctaggaggat tcataggcgg agcagccgga tacgaaggga ttttttggat 3080701 acttgcggcc atctctatcg ttttgctggt gacaaacagc atcacctttc ctaaagattc 3080761 tccaactgaa tctatgcagc aagccaaagg caatgtgttc gctcattata aatcaatatt 3080821 tacaaatcga acagggaacg tcattttgac tttaagtttt gttctctttt tcatttattt 3080881 tgcagtaatt gtctacctcc caatattgct gacagagcat taccatatag atgtgggtat 3080941 agcaggactg ttatatttgc cgctggcgct gagcacgatt gcaggtacgt ttctgtttaa 3081001 aagaatacag gcaaaaatcg ggctgcacac cttgtttatc ggaagcaatg tgattgccgc 3081061 ctgcagcatc attttatttg ctgttacaca ttccgtttct ctcgttctca tggctctgac 3081121 gctggcactg tttggcatct cgatgggggt tattcctccc ttgtactcta caatgattac 3081181 taatgaattt gagcacaaca gagggagtgc aatcggaatg tttaacttta tccgatatac 3081241 aggcatggca gcaggtccga tggtatctgc ctacttgctc acaatgatgc cgtctgccat 3081301 gtcctttagc ctcctaggcc ttggatttgc cgcattgagc ttttgccttc ttccgccaat 3081361 gttttcgccg cagaagcgca cgaaacaaaa aaagcaccac atgtaaaaaa gctgcctttg 3081421 cgggcagctt tttttatttt tttctaagcg gctctaaaat gcctttttga atcagcaaat 3081481 ggaagaccga caggataacg gatgcccata tcgctgtgcc gaagccgtcg atttgaaagc 3081541 tgtcacccat aatggacgcg gtcatcataa gcgtgatggc gttaatcaca aacaagaaga 3081601 gtccaagcgt caccatggtg accggcagtg taaatataat taaaagcggt ttaatcagca 3081661 cgtttaagat cgataaaatg aggctggcga taatcgctgc cccaatgctg ctgatatgga 3081721 tggagtcaat atatccatca atgacgatta ataacaatgc attgactaaa atgctgactg 3081781 cccattttac catgtcattt catatccctt tctgacggga cgataaaaat ccaaatgata 3081841 taaatgagca aaaccggcaa gacacttgtc ataatggcta agatgacagt tatgactctg 3081901 aggagtgatg cgtcccaatt gaaatattcc gcgagacctc cgataacacc ggcgattttc 3081961 ttattttttt ctgagcgata aagcttattc attcgatcac ctctgtgagt actttagttt 3082021 gatggcgcct gttagtgatt ctgagaagac ggtgatgttt tgatcatgtg cctgatttga 3082081 agtgaacatc atttcttttt gaatcgtatc atttttttcc ttcagcatct ctacatccat 3082141 taattcatgg gacagcgtac caagattgct tttcagctct gccttcactg cgagatcgtc 3082201 cggaattgca agctctacat ttccagtcgt tgtttttgca taaatggagc ggcagtctga 3082261 ttctgttacg ttaatcgcaa tatttccgtt aaagctttga acgtcaatgg attcgctttt 3082321 ccctcggaga tcgatcaatc cgttaatggt ttccgcttct atcgtaccgc agctgtggct 3082381 tgcgagctta atttgcccgt tggccgtttc agctatggct ttttcggctg ttaaatacga 3082441 gaacgacagc acgccgtttg tcgttttcgc tgagaactct tttacatgta aatgttcccc 3082501 tctgactgga ccgttaaaca gcttcacccg aatcttatca tactccttct gaggaatata 3082561 caaagtgaca ttcgttttca tcgtcttttt ctcagtacgg ataaaaaact tattaccttt 3082621 gatttcacat tcaatatgct gaagaaatgc gtgtctcgcc gcatcctggc tgtcagcgcg 3082681 atataccttc gcctggcatt ccgctctgat atcgtcatct tcccaaggga cgatatttac 3082741 gctgccattg gcaatttgca gctcaacact ggaaaagtca gtatctttaa attgaaaaat 3082801 gtgctgaaca tcatacgcat ggccaaagtt taaatcaagg tcaacttcct tgaccttttt 3082861 cacagcagaa tcaatccagt caaacagctt ggctcctaaa gacggtttgc cgctttcttt 3082921 ttttgccgtt gtaaatggct cttcctcgtc atgaacgtga actgagagcg ctgtgatttt 3082981 ctcttctttt tccttgtagt cgctgtcaag cttttcaatc agtgtcaaag cttcttgtgc 3083041 tgtaagcttt ccttcctcaa caagcttaag gattcgttcc ttttcttgct tcattacgat 3083101 ctcctcccca ttgtctactt atgctgcacg caggacctta atgccctgaa tcacattcca 3083161 aatgataatg ccaatgacaa ctaagaaata aataaccgct cccccgatga ttacaaatac 3083221 aggaagcaag ctgtctccat caatcgcaac ggctccgcca agtaaagcaa taaaaaggaa 3083281 cagccagccg acaaacggaa caatgtgaga aataagagag cgtatcgcat ggcgttttgt 3083341 ttctttctca tttacaacaa aatatgcgac aatcggcaca atgattggcg caatgaacac 3083401 actgaaataa caaagtgatg caataatagc ttgattacgg ttcaattcat tccacactcc 3083461 tattgtgaat tgtccatgac aaaagatcag ggacgtttta cttatttata cgtttaaaat 3083521 ctcttcaggt ttcaaattca ttctttagac atgctccgat ttacggaaat tggattttaa 3083581 aaagttttag aagtagaatc ttccggctat accgattaca atatgtaaaa agcttacggc 3083641 aaccaaggag gctggacaag caatggagaa agatcccagt gactatacag taacacaaga 3083701 atcagtgtta aagctgattc aggaacaaaa aagaatgaat cgtgaaatga tcaccgagct 3083761 tgagcagatt cacggaccct tcccgatctc tcacgatatc caatatataa aagtgctgct 3083821 cgacagcagc aacacacata ttgttcaaga tttaatgagt gtaagtaagc agctgtataa 3083881 gaagactttg taattgcgga aaacatatca ttcattataa ctgaaacaaa gctaaaggtt 3083941 agatgacaat atcttgcctt ttttgttttg aaaaaacaag tgattccctg gctgtcacaa 3084001 aatgattgta acaaaaaaag cctgccggca catccagtta atggactctg tcggcaagct 3084061 gtaactatca gaaagagata gccgttcaaa attaacgtaa caattgaagc acgttttgcg 3084121 gctgttggtt tgcttgagca agcatcgctt gagaagcttg agaaggaatg ttgttctttg 3084181 tgaactcgct catttctttc gccatgtcaa cgtcacggat acgggactca gcagctgtca 3084241 ggttttcaga agaagcacca aggttgttga ttgtgtgctc tagacggttt tgtaccgcac 3084301 caagtttagc acgttggttt gagacattgt tgattgcagt atcaatactt tcaagttgtg 3084361 tatcaaaagg agtattagca aaatctgtta cattaagtgc gtttactcct aaagcagttg 3084421 atgacatgct gtcaatgtta actgtaagct gctggccagc atttgctcca atttggaaag 3084481 tgaaaccatc agtttcagta ccatctaata actttttgcc gttgaattca gtacgatttg 3084541 aaatgccatc aacttcctca ataagcgcat ccatttcatc tttaattgca ccaagatctt 3084601 ctgcttgttg tgtacctgtg tttcctgctt gaacagtaag ttcacttcta aacctattat 3084661 gccgtaaaga aaaagcttgc ctgctaagcc caaggatgga cttgccgaca agctgtcccc 3084721 tcttaacaga gggttttaag atgtagctgt ttcttttgct ttcaagagcg atttcatgcg 3084781 tgttttgtca cgttcgataa caggctttaa ataacggcct gtatacgatt cttcaacttc 3084841 agtgatttcc tcaggcgttc cagacgcgac aatggttccg cctccggctc cgccttccgg 3084901 gcccaaatcc acaatgtaat cggccgtctt aatgatatca agattgtgct caataaccag 3084961 tacagtgtct ccgttgtcta ccaaccgttg cagcacgaca agaagcctgg cgatatcgtc 3085021 gacatgcaaa cctgtcgtcg gctcatctaa aatgtagagc gtacgtccgg ttgagcgttt 3085081 gtgcagctct gacgcgagct tcacgcgctg cgcttctccg cctgacaagg tcgtcgccgg 3085141 ctggccgagc gtaatataac ctaaaccaac atcataaagg gtttggagct tgcgtttgat 3085201 tttcgggata ttttcaaaga aagaaagagc atcttcaacc gtcatatcaa gcacatcaga 3085261 gatgcttttt cctttgtacg tcacttcaag cgtttcacgg ttatagcgtt tgccgtgaca 3085321 cacctcgcat ggaacgtata cgtcaggaag gaagtgcatt tcaattttaa taatcccgtc 3085381 tccgcggcag gcttcacatc gtccgccctt cacgttgaag ctgaaacggc cttttttata 3085441 gccgcggacc ttcgcttcat ttgtctgcgc gaatacatca cgaatgtcat caaatacacc 3085501 ggtgtatgtc gcagggttgg atctcggcgt tcttccgatt ggcgcctggt caatgtcaat 3085561 gactttatct aaatgatcca aacctttaat ctctttatgg ctgccgggct tcgctttcgc 3085621 tttatgaagc ttttgcgcca gcgccttatg caaaatttca ttaacgagtg tactctttcc 3085681 tgaaccggaa acacctgtaa ctgctgtaaa cgtcccaagc gggaacttgg cattcacttt 3085741 tttcaggttg ttttctgatg cacctttaat ttcaatgtaa cgtccgtccg gctttcttct 3085801 ttcaggaggc aatgggataa actttttccc tgataaatag ctgcccgtta atgaatttgg 3085861 atcttccatc acttcttccg gcgtacccgc agatatcacc tgtccgccgt gaatgccggc 3085921 tcccggtcca atatctatta aataatctgc tgccatcatc gtgtcctcat catgttcgac 3085981 aacaatcagc gtgttcccga ggtctctcat atttttcaga gcgctgatca agcggtcgtt 3086041 atcacgctga tgcagaccga tagacggctc atctaaaata taaagcacac cggataaacg 3086101 cgagccaatt tgagtcgcca gcctgatgcg ctgcgcctct cctccggaca atgtacccgc 3086161 tgccctgctc aatgtcaggt aatcgaggcc gactttgtcc agaaagctta agcgctccac 3086221 aatttcgcgc aaaatcaaat tggcgatctg catatccttc tcagaaaggg taagatcttt 3086281 aaagaaggca agtgcgtcgg cgacagacag ctcggtaatt ttcccaatgt ggcggccgtc 3086341 aatcagtacg gcaagcgcct ctttctttaa ccgatagcct ttgcacgtcg gacaagactt 3086401 ctgagacata tactgctcca tttgctcacg tatgaaatcg gagcctgtct ccttatagcg 3086461 tctttcaatg ttgcgcaata cgccttcaaa ttgaatttca ccttcgcgga tttgtccaaa 3086521 atcattttca tatcggaaat aaatcaggtc atccccgctg ccgtacagca ctttatccag 3086581 ttgatgcttc ggcaaatctt tgaccggcac atccatatca atcccgtagt gggtgcagac 3086641 tgcctcaagc agctgaggat aatattgtga gctgatcggt gtccaagggg cgaccgcatt 3086701 ctccttcaat gacaaatctt gattggggat gacaagatcg gcatccactt caagcttcat 3086761 tccgagaccg tcacacgtcg gacacgcccc gaacggactg ttaaacgaaa acagacgcgg 3086821 ctcaagctca ccaattgaaa atccgcagtg cggacaggca tgatgctcgc tgaacatcag 3086881 ctcttcctca ccgatgacat cgatcataac ccgtccttca cctaaacgaa gcgccgtttc 3086941 caatgaatct gacagccggg ctgccacgcc ttctttcacg acaatccggt caatgactac 3087001 ctcaatggaa tgcttcttgt tcttttctaa ttcgatatcg tcggaaagct cagccatctc 3087061 gccgtcaatt ctgactctga catagccttg tttcctaatc tgttcaagca ctttgacatg 3087121 agcgcctttt cggcccgaga caatcggcgc cagcacctga agcttcgtcc gttccgggta 3087181 ttccagaatt ctgtccacca tttgctcgat ggtctgggat gtaatctcaa ttccgtgttc 3087241 cggacaatga ggcttcccta ctctcgcata taaaagacgc agataatcat aaatctcagt 3087301 taccgtaccg acagtagacc tcggattgcg gctcgttgtt ttctgatcaa tgctgatggc 3087361 gggagagagc ccctcaattg catccacatc cggcttatcc atttgcccta aaaactggcg 3087421 ggcataggca gacagcgact cgacataccg tctctgtcct tcagcatata tcgtgtcaaa 3087481 ggcaagggag gatttacctg atccggacaa acccgtgaca acgacaagct gatctctcgg 3087541 aatcgttaca tctatatttt tcaggttatg cgccctggct cccttcacct ctatccgatc 3087601 catagccatt tgttcatcat ccttccgctt ttagctctaa aagtaaatcg cgaagctccg 3087661 cggctctctc aaagtcaagc gccttggcgg cttccttcat ttcatgctcc atctgttcaa 3087721 cgactttctg gcgttctttc ttcgtcattt tcgacagctt cggcgcggct tttgttttgt 3087781 attccgcttt atcctcagct gctactgtgg cacgaatgac atcgcgaatt tctttattta 3087841 tcgttttcgg cgtaatgccg tgctcttcgt taaaccgctc ctgctgctcg cggcggcgtt 3087901 ttgtttcatt aatcgcaatt tccatagact tcgttatttt atcggcgtac ataatgacgc 3087961 ggccttccgc atttctcgct gcccgtccga tggtctggat cagcgaccgc tccgaacgaa 3088021 ggaaaccttc cttatccgca tccaaaatcg caacaaggga tacttcggga atgtccaaac 3088081 cttccctcag caggttgatg ccgacaagca catcgtactt gccaaggcgc aggtcgcgga 3088141 taatttcaat ccgttcaagc gtcttgatct cagaatgcag atagtttact ttaatgccga 3088201 tttcctttaa ataatcggtc agatcctctg acatcttctt cgtcaaagtt gtcacaagca 3088261 cccgttcatt ccgctcgatt cttgcttgaa tttcgccgat caagtcgtca atctgacctt 3088321 cgattggacg gacgtcaata agcgggtcaa gaagccccgt cggacgaatg atctgttcga 3088381 ccatttcatc tgtatgttca atctcgtacg gccctggtgt tgctgataca tacacgatat 3088441 tgtgcatatg cttttcaaat tcctcaaaac gaagcggacg gttatcaagc gctgatggaa 3088501 gccggaagcc gtgatccacg agcacctgtt tccgcgcctg gtctccgtta aacatgccgc 3088561 gcacctgagg aattgtcaca tgcgactcat ccaccacgat cataaaatcg tctgggaaat 3088621 aatcaagaag cgtatacggc gttgaacctg gaggccgcag agtcaaatgt cttgaatagt 3088681 tctcgatgcc ggagcagaaa cccatttcac gcatcatttc aagatcatat cttgtccgct 3088741 gctctaaacg ctgcgcttca aggagctttc cgttttcatg catgaccttc agctgctcct 3088801 caagctcctt ctcgatattt tgaatcgcct tctccatttt ctcggcccgc gttacgaagt 3088861 gggatgccgg gaaaatcgca acatgatctc ggtcgccgag aatttctcct gtcagcgcat 3088921 ctacttcccg aatccgttcg atttcgtcac cgaaaaattc aactctgaca caatgctcat 3088981 cacgggatgc cggaaagatt tccactacat ccccgcgcac acgaaatgta ccgcgctgaa 3089041 agtcgatatc gttgcgggca tattggatgt ctacaagttt tctgagcagc tcgttgcgct 3089101 caatttccat ttcagtccgc agtgacacga ccatttcccg gtattcctca ggcgaaccga 3089161 ggccgtatat acaagacaca ctcgcaataa taatgacatc tctgcgctca aacaaagctg 3089221 atgtggcgga gtgtctcagt ttatcaattt catcattaat actagcgtct ttctctataa 3089281 atgtatccgt ttgaggcaca tacgcctccg gctgataata atcatagtag ctgacaaaat 3089341 actcgacagc attgttcgga aaaaattcct tgaactcact gtaaagctgt ccagcaaggg 3089401 ttttgttatg ggcaatcacg agagtcggct tattgacttc tttaatcaaa ttggacaccg 3089461 taaatgtttt cccagttcct gttgcaccca gcagagtctg atgcttcttg ccctcctgaa 3089521 ttcctttcac aagcttttca atggctttcg gctgatctcc ctggggctga tatttcgaga 3089581 ctaactcaaa gcgatctttc acaaaaataa gcctccgttt ctttaacgaa atcttcctat 3089641 agatatagta acacaatgga aagcaaaatc actaaaaata cgaactaaag ttcggtggtt 3089701 ttttatttcc agctgttttt gtgtataaaa aacctgcttt taaaacgtaa aagcaggtat 3089761 tcagtcttta tattcattat gtccgattta ttcttctttt ttctctgcag cttttttggc 3089821 catatacagt ccgccagcca caagagacac aacatccaat cctacaataa aatacgtttc 3089881 tgtatagcct tttaaataag aggcaaacag caatgcagct gttaaagcga tcgccacata 3089941 atgattaaag gtgactctag taaatagaac aacaagcata aaagggaaaa acaatgcaaa 3090001 aacggctttt gtaatcaaca aaaaccctcc tcagggattc ttcatctgat ctgattatag 3090061 taaaaaatga agaatcggac aatcgtgcat tcgctccctc tacttacacc ataccccttt 3090121 tcagccaaaa tcaatcacca tatttgcatt ttggtgccgg tcaaaactta ttccatggtg 3090181 ccgctgttct aatcagcggc acttttttta ttacatcatc aagtccgccg ccagattccg 3090241 agaataaaag aaaataggca tacagtacca gtacggccgc atttttcagg ataatataac 3090301 caacttaact attcatttta tttaggactt tctgcgtttg acagcatttt cctgaaaacc 3090361 tacaattaaa tgatagtgtt tactatcatt ttttaaacac aggctccgca ataaaaagac 3090421 tagagagaaa aacaaaatga atgaagaaaa gaggggtttc aaatatgtat tctgttttat 3090481 ttcgccaggc agaagagtcc agccagctgg ctggagcaaa aggaatgaat ttgattaaat 3090541 tgaccaaaca cggtcttcct gttccggacg ggtttattat tcaaacgaat gcgctcgcac 3090601 gttttatgga ggacaaccag cttcaagaga ctagtgaaaa cgtcgaaggc gggatcattt 3090661 ccggaacatt ttcggatgag ctgaaagatg agctgactag ttccttttat aagcttagag 3090721 aatcatatcg atccgtagcc gtgcgttctt cgtctgcttc ggaagattta gaaggcgcct 3090781 cattcgcggg tcaatatgaa acctacttaa atatcaaaac agaggaagag tttctggcta 3090841 aagtgaaaga atgctgggcc tcattttttt ctgggcgggt cagcagctat aagaaaaaaa 3090901 tgaacaatca aatcgcagag ccgttaatgg gaatagtcgt tcaggggctg atcgattcag 3090961 aaatgtcagg tgttatcttc agccgcaacc ctgttaccca tgatgataga gagcttttaa 3091021 tcagcgccag ctacgggttg ggtgaagctg ttgtttcagg aaatgttacc ccagacacgt 3091081 tcattgttaa taaatcttcg tttgagattc agaaagaaat aggtgcaaag gaaatctaca 3091141 tggagtctgc ggcagaagga attgctgaaa aagaaacgag tgaagacatg cgcagccgtt 3091201 tttgccttac agatgaacaa gtgattgaat tggctgaaat cacaaaaaaa accgaagacc 3091261 tgtacggata tcctgttgat atagaatttg gaattgctga tcatcaaata taccttctgc 3091321 aagctcgccc gattacaacc attgatcagg acaaaaaagc ggcagaagaa aaacgcagct 3091381 tcatgattac cgacactgat atgaatgatt tctggcttaa catggagtct aatattgaag 3091441 gtccggtgag tccgttattt tcatccttca tcgtgccggc attggaatat ggcttgaaga 3091501 agagcatgca aaagtttccg attggtgtag ttgttgatga agtaaaactt tatcgcggac 3091561 atatttattc caaaaaccaa ggcggacagc agcctccttc tgaagactgc ggcaaagagc 3091621 ttttcccgat tttatcggag catatgtatg acatcatcaa tcacacatac ctcccttttt 3091681 accggacact ggaccagctc gcacaaactg agcataccgc agaaagcgca ctggaagctt 3091741 ttcaaaaact aaaggccttt tatctcacgg cttatgaaga gcactttaat atcgttttcc 3091801 cgcaaatcct tttaacaaac aaactgcaag cgatgtatca ggacattcaa ggagagtccg 3091861 aaaacgctca tttttacgag atgctgacag gaaaaatgaa caaatcactg gaaacggacc 3091921 gttgcttatg gctattttct gtggaagttc aggagaaccc gaaccttctg gccatttttg 3091981 aaaacaacaa gcctgaacag ctccaggaga aattggaaca aacagatgag ggaagacact 3092041 tcctgaagaa cgtccatgaa ttcttgcaag aatacggatg gagatctgtt aaaagtcatg 3092101 atctgattga acaaatctgg gtggaaaatc cgtatttcgc tctggccaat attcaaaatt 3092161 atgtccgtaa tggctatcat tttgacaatg aatttcagaa aacaaaagaa aaacgagaga 3092221 aattatacaa tgaattcttg gaaagcatag aagatcccgg tttacgcacc gaatttgacc 3092281 gctattatca atggacactg aactctgcaa atataaaaga tgatcaccac ttttatattg 3092341 acgccatgct ggatgccaag gcgagaatct ttctgctgaa gataggtgaa ttgctggcgg 3092401 aaaacggtgt cattcaagat cgggaggacc tttggttctt atatgacgac gaagtggaac 3092461 aagcgcttct tcaccctgta tccctgcaag aaaaggctga aaaacgcaga cagatttttc 3092521 atgagtatga gctggcccaa gccccggcct acctcggcac cccgacaaaa gaacagctca 3092581 aagcagctga agaaattgtc ggcgctgtga tagaggatga aaaaaacaca gagaatcata 3092641 tttttggcat tgcggcatca agcggcattg cgacaggtcc ggtgaaaatc attcgggacg 3092701 ccaatgaatt ttctcaattc gcgcctggag acgtactcgt ttgcaagatg accacaccgc 3092761 tatggaccag cctgtttcaa gacgccaaag cgattattac agacacaggc ggcattttgt 3092821 ctcacgctgc gattattgcc cgtgaatacg gcattccagc cgttctcggc acacgcacgg 3092881 caaccgaaag actgcgagac ggtgacatca tcactgttga cggaagcagc ggcaaaatca 3092941 cagttgtcag ccggtcctga tgcgtccccc tctttcttat acaagcgggg cgggtgtata 3093001 cttgtcctgc cagtatattc gtgaggtgaa acgtattgag accgacaaac aagagaatcc 3093061 ttgatgctgc catgcagctg ctcgtcaaaa aaggatatcg cgcaacgact acaaaagaaa 3093121 ttgcagaaaa agcaaatgta agtgaagcga cgattttcag gaactttaaa aacaaacaag 3093181 gactagttga ggctttgctt tctcagcatt cttcaaacag aggcagcatt ttggaacaaa 3093241 cagaagggga tttgtacaaa gacctgcttc atatcggaac ctgtctcttg gaggagctcg 3093301 aacatagaaa agatatcatt aaaatcagct ttcgtgaacc ggccatgttt caggatgtca 3093361 ttaaccacgt cactgaatat ccccaatcta tgaaacagct attggttgat tatctcaaaa 3093421 cgatgggtga gaaaggggtt attcagacag gaaatgaagc ggaacatgcc gacgtgttca 3093481 tgtcgattat cttcggttat ttcattcacc gtctccactt aggagaccgg gtcatatcaa 3093541 tgccccagga aaaaatgctg gagcatagca cagctctatt tgtcaaagga atttctgctg 3093601 attaactcct tggcataata aaaaggagga tcccaatgag ctcaagaaaa gaatgggcgc 3093661 tgatcgtctc gctattattg ggggccattc tggttcccat taactcaacg atgatcgcgg 3093721 tcgcgctctc atctatttcc catacgtata acgagtccat cgcaagcatc acttgggtgg 3093781 ttaccgttta tttaatcgtg atggcagtca cacagccgat tgcaggaaag ctcggtgaca 3093841 tgtacggcaa taaaacaatg tacttatggg gagtcggcct ttttctaatc gcatctctag 3093901 gctgcgccct ttcaccgagt ctgctcctgt taattgtctt tcgggcattg caggctgtcg 3093961 gcggggcatt gcttacgcca aacagcattg ccattatccg gcatgttgtt tctgaaaaac 3094021 gcctaccgaa agtgtttgga tttttcggac tgggcgcggg acttggtgca gcactcgggc 3094081 cttttatcgg ctctatactg attgacagct tcagctggca ttcgattttt tgggtcaaca 3094141 tcccgttcct cgccattgct ttatttacgg cattaacgat gtttcctcaa tataaagaaa 3094201 ataaatctga cgcgccgctg gatatcatcg gctctctctt gcttgcaggc agcatcgttt 3094261 ccattatcct gctgacgaaa aatgaggctc catggggata tactgtatac agtgtattga 3094321 tacttctttt tgttccgctt tttttcagaa gagaaaaacg tacccagcac cccatcattg 3094381 actttgcact gtttaaaagc tcaaccttta caaatgcgaa tctatcagtc ttgttaagca 3094441 atttgatgat gtatgccgtc ttattgatta tgccgttatt tatgacgaac caatttgggc 3094501 ttaatacatc taacagcggg atggcgcttt ctgtattttc gatcttcatg tcagccagca 3094561 actgggtggg cgcgcagctc catcacaaat ggggagccaa aaaaatcatt tttctttcat 3094621 ttgccatgat ggctggtgcg aatctattat ttttgctgtt aagcagctcg cattctgtct 3094681 tgttcctcat gctctctctt atccttggcg ggctcgcttc cggagtcggt ctgaccagca 3094741 tgcaggtttc atcccttgcc acagtagacc ccggtatgtc aggagtggca tctgggattt 3094801 tctcgacctt ccgttatttc ggaagcatca tttcatcagc cttaattggc ctgatttcgg 3094861 gatatcacac cctatttatg attctctttg ctgtatccat catcggcgtt tttgtttcat 3094921 tgggcatcaa atctgatgaa acggcacgga tagaaaaaaa ctcagcgtaa cacaaaacag 3094981 cccggcatcg catcatcctg cggtgccggg ctgcctttta tgatcccgaa gcgactgctt 3095041 cgtcttcacg gtcatccttt acgaagagga tgcccaattc atgatgttct ccttcataag 3095101 aagctcgctg gtcaaaacga atttctccat tcaaaccgat aatttcaagc tttacatatg 3095161 cacggttatg ctgaagcgct tcatagaaat cagaaacgtt cttaaccggt atgccattga 3095221 ctttcgttat gatttccccg attttcaatt ccagatcctc agccggcgta ttggggataa 3095281 tcccaagcac cattaagccc tgatcccttt tcgagaaata aaacggagcc gcgttatcat 3095341 tcactctttg ctttatggac agaaaaatac gccctaacaa agcggtacag accgctgcac 3095401 ccgcaagcgg cgtccacagt aagctcgctg caccgagaac tgcgacggca agaccgagaa 3095461 tacaaacgcg tttcgctgtg atccttatac tcgtttcagg cagcgatccc tgtacccttt 3095521 gtccaaatcc gacaaagtaa ggaatccata gaaaatggaa tgagccgccg ggaaccgtaa 3095581 acacgggcca ccagctaagg tgcgattcta aaccattacc gggcacgaga aggaacagcg 3095641 gcaaaagcca aacccggttt gccagctgct gtccgatcgg caaaccgcgg ctgcttacga 3095701 caagtgccgg tgatgttctc acatgcgcag aacgataagc aaccgctcct tcagtgataa 3095761 tcagcaaacc tagaaacaca gccacagccg gccaaacaac tgcaaatcct tgcggaaatc 3095821 tctccagaaa gggctccgcc tgatatattt gcagtccaaa acctatcagc atactcacac 3095881 tgacgatata tgcagcagac atccagtttg cgcgaagagt gaacgctgcc gctgcagtga 3095941 taacggcaat aatcgcaagt aaaccgagag gaatcgatat tccgagtcca cctaaaataa 3096001 ctgacaaaag aagacctgga atcagtccct ttgtatatgt aaatttcaga tcatcataaa 3096061 tatctgctat tcttgtatga aaggtttttc gttcccgttt gattcttaca tagccgaaag 3096121 ccaaggttat gatgataaaa aaccagaaaa gcgggtgtaa gaagaacaag cccgcgcttt 3096181 ttaacagttc aattccccat tgaacagaca ctatctctca ccgcctcaag ccaaacatgt 3096241 tactcatatt ctatcaaata ttaaatggct tggatatcct caggagagtt tatctctctt 3096301 gcgtcatcca cagcgtgaca ttcgatagtg aaaaatcctt taaatagtgg tttacatcca 3096361 catccaataa cccgctgatt agatgcatcg acctttttat atctgtcaga ttaattccta 3096421 atcgcttatg gtttttcatt aagtagttaa aataatgttt ggcgcattcc tcattaatgt 3096481 catttactga ttcgacattg gtgtaattga ccaaatatct gctgaacagc ataagaagac 3096541 ttagtgcttt tgtagctgaa aatgttacgt cttgtgttct gtcttttaat tgttccacta 3096601 attcataata tttttttttc acgcacaata cttgccctct tcaattgtga acccccattt 3096661 tctttataca gataagcacg ggccagtata agcagcagta ctggagtgct aacaagcatt 3096721 ctcgctaacg ttactcttta aatacctgtc gttcagctgc cattaacctg attactgttc 3096781 tttttagaac cttcttatat tgtatgaagt aaacaaagac taggcaactt gcaaaagttt 3096841 cattttaaat gcatattaac tcgttagaaa gtctctctca tatattgata tcgggtaata 3096901 acagtccttt ataaatgttt atttgtgaaa atttttttaa tttcttgtca aaaactcatt 3096961 ttttatgtga cttatgatcc ataatctctt taagcacaaa gaaacaggag atgaaatacc 3097021 atctccttta attgacaaat aatgatttca atgctgtttg aagctgcaaa tcattttttt 3097081 catctgattt tttcttttct atctgctgat ttaatgtctc tgcagtgcga gtgtcgatca 3097141 caccggtttt attcagcttg ttttgatcct gaaaagccat aaccgctttt ttcatgtctt 3097201 tgctgaaata gccatcctca cgtcccggat caaagctgag accttttaac aatacctgcg 3097261 catgcttgac gtcttcattg ttcatgtcca ctttaagcgg ctctttcagc tgtaagggcc 3097321 cggcggaaaa ataatcgggc tgcttaatcg caatggtcgg ttcaattcct ttcttatgaa 3097381 tccagtttcc atttggcgtc agccacttgt aaagcgttaa tttgatgttg ctgccgtccc 3097441 ccattggcac agcctgttga accgttccct ttccaaaaga cgtatcgcct acaacatcat 3097501 aatggccagc ttcctttaat gcgccggcaa gaatttctga tgcagaggca cttcctttat 3097561 ccgtaatcac attgacaggg tacgcttttt tatgggtcaa tgttgaaaaa taacgttttt 3097621 tatctccatt gcgttcagca atctgaatat acggctgatc ctttgtaacg aaatgcttaa 3097681 gaatttcttc cacactttga agatatccac ccgggttgcc gcgtacatca atgacaagtc 3097741 cttctatttc ttttttctca agctccctca gcgcttttgc aaaatcctct gcggtgtgct 3097801 cagaaaaagt agagatggca atatatccga cagaatgccc ctgtactttt ttctctgatg 3097861 caaaaaccgt ttcgagcgga atctcagctc tcttgatccg gaatgacaac tgcttcttcg 3097921 ttccaggccg ctgaatcttc attgaaacgc tggacccttt ttttcctctt atttttaaca 3097981 cagcgtggtt taaatccttg ccggccatcg attctccatt gatgctgata atttcatcat 3098041 taggcttcaa cccggctttt tccgctggcg atttcttgaa tggagaaaca ataataattt 3098101 tgccgtcttc cattccaacc tcagccccga tgccttcaaa tgaggaatca agagaatcag 3098161 aaaattgctt agctgtctgc ttgtccatgt aaacagaata aggatcattt agcgtagaca 3098221 gcattccctg gatggctccc tcgagcagct tttctctatc tactttttct acgtactcat 3098281 tcgaaattaa ctcatacgct ttttcgattt tgtccatagc tttatcccgt tcagagtcag 3098341 cttgtgccgt cgcgggaact gctgcagtct ggggcttatc catctcaagc aggttgattc 3098401 ccgcatatac accggcgcct ccgaacagca tgctccctgc tgctatcaca gccattattt 3098461 tttgattcat cctttactcc tcctgtatgc cagactgtct ttaccaaaac ctagagatag 3098521 tatatgtaaa ggatggagat ttcatgtaat catagaagaa aaagaaggca aatgaaaagc 3098581 cgtcccgaaa acggaacggc tttttcactt tatactcgca gaaacttgcg gatggaagtc 3098641 agacttcccc atactccaat tactgcgccg attgcaatca gcactagcga aacttggaat 3098701 acaaatggat tataaggaag aagagagaca aatgatcctt gaacctttgg aacgacccat 3098761 ccgatgacgt attggtaagt gctcagcacc agtgcaatcg gaatcacaga accgaatacg 3098821 cctagcagca atccttcaag gaaaaacggc cagcggataa accagtttgt cgcgccgaca 3098881 agcttcatga tttcaatttc ttttcttctt gcgaaaattg taattttaat ggtgttggaa 3098941 attaagaaca tcgccgtaaa taccaggccg ataattaacg cgattccgat gttgcgggaa 3099001 acgccgacca ctttaaacaa acggctgacc tcttcttttc cataagtgac tttataaaca 3099061 tgatccattt tttcgatctt tttcgccacg ttcggcgtat catgcggatc tgtcgttttg 3099121 acgacaaacg catcattaag cgggttttcc tgatccttca ttgtcaggga ttttccgctg 3099181 tcaccaaaac tgtcaaccag ctggtcaagc tctttttctt tagatgaaaa agtgacactc 3099241 tgaatgccct tcagttcctt aatatcgttc tgaagcttgt cctgtgcctt ctgatctgca 3099301 gtcagatcaa tcagcacttt gatttcgact tgtttttctg cattcgtggc catgttattc 3099361 aaattcagca taatcactaa aaacacgccg actaaaatca gcgtaacggt tacagcacta 3099421 atggatgcaa atgtcatcca tgtgtttctc ccgagagatt taaaactctc acgcaagtgg 3099481 cgcccgagaa ttttaatcat atgaaccata ctcccctctt gactcatcac gcacaatgat 3099541 accatcttcg attgcaatga cacgtttctt catggtgttt acgatttctt tattatgtgt 3099601 cgccatcacg actgttgtcc cgcggttgtt aatttcctcc agcgtcttca tgacttccca 3099661 ggacgtatcc ggatcaaggt ttcctgtcgg ttcatcagca atgacaacat cagggttgtt 3099721 cacaattgat ctggcaatag atacacgctg ctgctccccg cctgaaagct ggtcaggaaa 3099781 ttgtcgcgct ttatgcttca gctgcacgag atcaagcact tcaagcaccc gtttcttaat 3099841 gacagacggc tgttctccaa tcacttcaag ggcaaatgcc acattttcaa aaacagtaag 3099901 tttcggaaga agcttgaaat cctgaaagac aacacctatt ttgcggcgca cgaaaggaat 3099961 ctctttttct ttaattgtcg cgagatcttt atgattgatt aaaatttgtc cttttgtcgg 3100021 tttttcttct ctgtaaatca ttttaataaa agtagattta cctgctccgc tcggaccaac 3100081 aacatacaca aactcgccgg gatgaatggt aacagaaatc ccattgagtg cttttacgcc 3100141 gttcggatag gctttatata cttccttcat ctctatcatg aaatcaccta atcttttata 3100201 tcattttatc tatcacacgg tcatactctt cgaatgcatt cgacaattta tgacccattc 3100261 atttgtaaaa agatgaaaaa tctgaaagtt ccctttttca atacacttca ttatacgtca 3100321 aatttagaca taatactatt acagtttctt ttcattcata ttgtcaaggc ataaaaacat 3100381 ccttgccagc actcggcaag gatgttttta tcttactttt tttctgacag ccatttggca 3100441 ataacagcgg cttcgttatc atctacaagc ccctttggca tattgccgcg gccgttttta 3100501 ataatgcttt caattttgtg ttcatcgtat ttgcctccga cctcttggag attaggccct 3100561 gacacacctt ctaaatcctt gccgtggcag cctacgcagc tttgctgata taattcttcc 3100621 ccttcagatg cagtggcttc cgtcttgctg ccagtgtctg tcttctcttc ttttgcatcg 3100681 tttgatccgc aggcagccaa cagaacagaa agcgcaaatc caatcattag tatcgataac 3100741 tttgatttca tgttgagaag cacaactcct ttacgatctc ttccatatta taacctcgtt 3100801 taagcgcgtt tgaaaccctc gcccagcacc tcgctcgcgt ctgctacaat tacaaaagct 3100861 gactcatcaa tctgtttgac gatttgtttc aatttggtga attcagtttg cccaaccacg 3100921 cacattaaaa tcggacggtc atcgtcagta tatccgccga ctgcagaaat ttttgtcacg 3100981 cctctgtcaa tcttctgtaa gacagcctcc ttgacagcct gctcctgctt tgtaatgatg 3101041 agcgccattt ttgaacgatt aaagccgact tgcacaacat caatggtttt gctggacaca 3101101 tagacgccaa gcatggcata taagccttgc tcaatattaa atacaatcat agccgtaaca 3101161 acgatcattc cgtcaatgat ggcgagacac ttccccaatg acagaccgga gtacttatga 3101221 atgatctgtg cagccaaggc tgtacctccc gtcgaacctt tccctaagta cacaatacca 3101281 attccgatac ctatcccgac accgccaaaa atcgccgcca ggagttcatg atgagtggcg 3101341 ggctgaatat cccttgtcag aaacactact agcggcaaaa acacagaacc tgcaagcgtc 3101401 tttagtccaa atttcccgcc gagcaaaatg acgccagcaa taaataaagg gatattaata 3101461 atccactgta catacgctgc ttcaaaacca tatgattgta aaatcgtact gatcccgctg 3101521 accccgccgg cggcaatctt attcggaagc aaaaatacat taaaggacac ggccgtaatc 3101581 gctgctccta tcaatatgta tacataatcc cgcaaaatcc acaatgtttt attccgtacg 3101641 tccatcatat atcctccgtt tcttccaatg ctctccgata gcattttaat ccttccctga 3101701 ttagatgtaa ataacaccca aatacagtgg taatatgcta aagcagcagt gaaatcaagg 3101761 atataagaaa taaaaaaaca cacccgtatg catcaggtgt gtttttcagc ttatgaaagc 3101821 ttagaacgca ggtaggcatc aataaacgta tcaatgtcac catccattac agcttgaacg 3101881 ttccccattt ctgtattggt ccgatggtct tttaccatgg aatacggatg gaatacataa 3101941 gaacggattt ggctgcccca gccgatttct ttttgttcac cgcgaatttc atccagctct 3102001 gcctgctgct cttcaattct gcgctgatac agcttggcct tcagcatttt catggctctt 3102061 tcacggtttt taatttgtga gcgctccgtt tggcatgtca caactacgtt cgtcggcaag 3102121 tgagtaatcc gaacggctga atccgtcgta ttgacgtgct gtccgcccgc gccgcttgca 3102181 cggtacgtgt caactttaat atcctccgta cgaatatcaa tatcaatttc atcgttaaat 3102241 tcaggcatga cttcacatga aacgaaagat gtgtggcggc ggcctgatga atcaaatggt 3102301 gagatccgca caagacgatg aacacctttt tctgctttga gatacccgta agcgttgtgt 3102361 cctttgatga gcaatgtcac tgacttgatt cccgcctcgt cacctggaag gtaatcgaga 3102421 gtctctactt taaagccgcg gcgctctccc catcttgtat acattctaag aagcatagag 3102481 ccccagtcct gtgactctgt accgccagca ccagggtgca gttctaaaat cgcgttattt 3102541 ttatcatacg gctcgctgag aagaagctga agctcaaact cattgaactc ttttgttaat 3102601 gactttagtt ctttttcaag ctcaagctgg agatcagtgt ccggctcttc tttcaaaaga 3102661 tcatgagtca tttgtaattc ttcgtgggat tcattcaatt ttttatacga attgacataa 3102721 tcctttaaac cgtttgcttc atttataacc gtttgagctt tttgctgatc attccagaat 3102781 tccggatcag ccatttgttc atctagctca gcaatgcggg cctcctttga ttcgaggtca 3102841 aagagacccc ctaaagtccg ctaaacgaga agccatattt tcgagctctg ctctaatttc 3102901 tgataattcc atttcattca cctcattaaa agatccgcag gcgcctgcag gcgccgcggt 3102961 cagtaaactt gccggggcga actattcagt acggccgcag caatttttat attttttccc 3103021 gcttccgcag tggcatgggg catttcgtcc gatatcaacc actttgcgaa ccggtgcttt 3103081 ctttgctttt ttgttatcgt cgccttcttg cggctgatga gctgttgttt gaccttgtac 3103141 aacctcttca cgctccagat tgttttcaat ctcagctttc atcacaaatt ttgcgacttc 3103201 gtcctcaatt gattcaatca tatgctcaaa catcgcaaaa ccttccattt gatactcacg 3103261 aagcgggttc gtctgcgcgt aagcacgaag gtgaatccct tggcggagct gatccatcgc 3103321 atcaatatga tccatccatt tagaatcaac ggcacgaaga acgataactt tttcgaattc 3103381 gcgcatttgc tctttgccga attgctcttc cttctcatta tattttgtga tgatgcgatc 3103441 cataatgagc tcaagcattt catccggttc tttgccgaag atatcgctct tctcaagtgc 3103501 accttcatca agataagttg tgttgataag atcaactaga ccgtcaagct tccactcctc 3103561 aggaagctct tctcttggcg tataggctgc aattgcgcgt tcgagagaag acttgatcat 3103621 attttcaacg atttcacgca ggttttcaga gtcaatgact tcaaagcgct gcttataaat 3103681 gacctcacgc tgctggcgga gaacatcatc atattgcaga agctgtttac gcgaatcgaa 3103741 gttattgcct tcgacgcgtt tttgagacga ttcaaccgcg cgagatacca ttttgctttg 3103801 gattggagta gagtcgtcca tgccgaagcg gtcaagcatc gccattgtcc gctcagctcc 3103861 gaatctgcgc atcaattcat cttccataga aagataaaat tgagtaatcc ccgggtctcc 3103921 ctgacgtccg gaacgacctc gaagctgatt gtcaatccgg cgtgattcat gtcgttctgt 3103981 tccgactaca gcgagcccgc caagctcttt tacaccttcg ccaagcttaa tgtccgttcc 3104041 gcgccccgcc atgttagtcg caatcgtaac tgcgcctttt tggccggcct cttcaatgat 3104101 ctgcgcttca cgttcatggt ttttggcatt taacacttga tgcggaattc ctttgttttt 3104161 aagcagctta gaaatcaatt cagatgtttc aacggcaacc gtaccgacta gaacaggctg 3104221 tcccgtcatg taacgctgtg cgacatcctc cgcaactgcc ttaaactttc cttccatcgt 3104281 gcggtaaatt aaatccgggc ggtcatcacg gacaacaggc ctgttggtag ggatcgtgac 3104341 aacctgcatg ttgtagatgt tgcggaattc ttcttcctct gtcttagctg tacccgtcat 3104401 accggcaagt ttttcgtaca ttcggaagta gttttggaac gtaatcgtcg ccaaggtcat 3104461 gctttcgttt tgaatctcaa gcccttcctt tgcttcaatc gcttggtgaa gcccctcact 3104521 gtagcggcgg cctttcatca gacgtcccgt gaaggaatca acaataacaa cctgtccgtc 3104581 ttccactaca tagtcaacgt ccttttgcat cgcaacgtga gcttttaagg cctggttgat 3104641 atggtggttg agcgcgacat gcttcacatc aaagaggtta tcgatgccga atgctttttc 3104701 cgccttcgtc attccttctt cagtaagctg tacagctttt gttttgatat cgtacgtgta 3104761 atccttctcc gcttttaacg tgcggacaaa agcatttgcc tgtacgtaca gcttagtgga 3104821 ttttgcagct tgtccagaaa tgataagcgg tgttcttgct tcatcaatta aaatagagtc 3104881 aacttcatct attaccgcaa aatgaagcgg gcgctgaacc atctgctctt tataaagaac 3104941 catattgtca cgcaaatagt cgaagccaag ctcgttgttt gtggagtaag taatatcagc 3105001 ggcataagct tcccgttttt cgtcttttga cattgagttt aaattcaaac cgacagtcaa 3105061 accgagaaac tcgaaaattt tccccatttg ctcagcgtca cggcttgcca agtattcgtt 3105121 gacagtcacg acgtgtacgc ctttaccggt taacgcattt aaataaacag gcagggtaga 3105181 cgttaatgtt ttcccttccc ctgttttcat ttccgctata tttccgtcat gaagcgccac 3105241 gccccccatg agctggactt taaacggaaa catgcctgtt acgcggcgtg aagcttctcg 3105301 aacaacagcg aaagcttcaa caagaagatc atccgttgtc gccccttttt caagacgctc 3105361 tttaaattca attgttttat gtttcaatgc gtcgtcagag agattttcat agtctccgcg 3105421 aatcgcatca atatcgttag caattttttc gtatctattc agcgtacgtt ttgttggatc 3105481 aaacatttta tttaaaattc caagcattta taacgctcct ctatcatcac acgcctattt 3105541 tagaggcatg tataaataat ttactagtcc atgtatacct ctcattatca tatcatacct 3105601 tttgttattt ccaaagaatt tgcaaataag aaaaacaaaa accttccgcg gacatcacgg 3105661 aaggcttctc ttcattattc agtcggttca attaagccat atttcccgtc atttctgcgg 3105721 tacacgacat ttgtaaggtt tgtttccgca tttgtgaaaa caaagaaatt atggccgagc 3105781 atattcattt gcaagatcgc ttcttcacta tccatcggct ttaaattaaa gcgtttctga 3105841 cggacgatgt ccaagctctc ctcctcttct atgtcatcct gaaccgcaat atctgtatca 3105901 gagccaagac cgtttgccaa taaatatttt ggagagccct gctcacggaa tttacggttt 3105961 actttcgttt tatgcttacg gatttgacgt tccagtttgt ttgttgcgag atcaattgcg 3106021 ttgtacatat cctcgttatg cacctcggac cgaagcgcca gatctgtcat cggaatcgta 3106081 acctcaacct tagactcctt gtcattgtaa aacttcaagt tgacgttcac atcagcatcc 3106141 acgctatggt caaaatagcg ctccagcttg ccgatcttcc tctcgacatg atcctttaac 3106201 gcgggtgtca cttcaatatt ttctcctctg atgttatagt tcatcaaaga acgcctccct 3106261 tttattaagg atatgtatct atttctcttt taccctttac aattcctgct gaaacataaa 3106321 tcttttgtga aaattcagtg aactttgtcg aattttgttt gtatttgctc tgttattggc 3106381 ggttcggagg tatatgtata tgctgattga acgaaacaaa tacctcacac acgcctaatt 3106441 gattaaaaag ggttccatac attgatgaat agacagcatc cattttctat aatgaatcag 3106501 aaaatgttcc tttaaatact cacagaactc atgagaggga aaagagaaag agaccaattg 3106561 atcaaactcc gcaaaaattt ggtcaaatgc tttcacacaa atttcagcac accgcgaatc 3106621 cataatgaag agaagtgttg aatgtgttga atccaaataa aaaaaggctt ggatcagatc 3106681 ttggtagatc cgatcccctt ctgtttttga taaattctct tcagcctcta tcaaataaca 3106741 caacccctct tcgatggtaa aaagaagatg ataataagct gataaaagcg tataatcttc 3106801 aatgctcttc aaggcactca cctatttacg cttgtcataa tatgtgccgt caatcgtaat 3106861 gttgttataa gggtttaaat acgtcgtatg catcacacgt tttcttttca tctgctgaag 3106921 ttctgttgcg attgactgct tcagtctttc catttccttc acaatcagct gatcccatgt 3106981 caaaataagt ttcatctgct ttcgctcttc ttctgaaagc ggcagagata tctcctgaat 3107041 cagttcagac cgtgtagcca caaagtcttc aatttgcttt aaaagttcat cgctttccgg 3107101 cgtattttgt atgtgtgaca gcatactctt cgtctcagtg tatagttgat ctatattatt 3107161 catgcgatcc cgcctgatcc gtgccggtcc ttccgctcac tttgaatggc ttgtttccaa 3107221 gcatcgcgaa aatctgttac ataaccttca acctcagcca gcatgcccgt atcatttttg 3107281 atatttgcct gtaccaatct gcgatacata taatcgtaca tcgcacccat agaagcggaa 3107341 agctctatgt tacggttaag tgtaaaattt aattcctgaa taatattttg cgctttaatc 3107401 agattttcat ttttacgttc catatcatca ttctcaatgg cctgagcggc aagtcttata 3107461 aatttcaaac agccattata cagcataagc gtcagctccc cgggtgtagc cgtattcact 3107521 gaattttgct gataggctgt atatggattt tggatcgcca tgtgtcatcc tccaaattac 3107581 atttattgta caagaagctg tgataaatag gacgcttgtt cgttcatttt ttgaatcgca 3107641 gaatccattg cactgaattt tgaataatag cggttttcta tggtattcaa tctgtcctgc 3107701 atatcagtta tttcagtact tatcgagttt aaattttttc caatggaata gctactagct 3107761 cccattgtcg agttcccagc tttagcttca atacttttca cagtacttct aagtgtatta 3107821 gtaatccgct tcataatacc tttatcgcta tagttactat catttgttcc acttgtaaaa 3107881 agattagcaa ctccttgagg atcttctgct atttttgctt tcaatttctc ttcgttaatc 3107941 tctaagtgcc ctcgcagttg gtaagcactt gaagttgtga tgccaaattc agttaattga 3108001 taggttttcc catccgcatt cacttgagta taaaagtcag tccgcatttg gttcgtgcca 3108061 gtgctgatgc ttgaatcgtt tctcagcaat ccgcttttcg ccttctcctc ccagagctct 3108121 acctctttat cggacatggc ttctttttgt tcactcgtga gtggcgtata gtctcggtat 3108181 ttttcttctt tcagcttttc attcaggctg tcaaccagtt cattgtattt atctacaaac 3108241 tctttgattt ggttataaat cccatcaaca tcagtagaaa cagatgtggt aacagggcct 3108301 gtggctgcag ttgtattttt aatcgaataa gtaacaccat tcaccgtgaa attgtttgtc 3108361 agcttctcca tttcaaagcc gttgattgtg actttggcat ttgtgccttc tttgtaagca 3108421 gtaagcttat tatcagcatc caaagaaaaa ccaagctgac cggacataaa gtcagctgta 3108481 gcagagtctg ctgcctgtat gcttcctcct gcacctgttg ctttagaaga aaacgcaatc 3108541 gtttctacgt actctgtacc attccaaatt ttatctttaa atgctgatac tcctagatct 3108601 gagctgttaa gtttagaaat cacattatca atcgtatcgg cactcgtcac actaatgttc 3108661 actgtttttg ctgttgtttc gccaggcgca acaacgttaa atgccaaatt gtaatcgcct 3108721 tgtgtgtatc ccgtataatt gtttgcctta tacgttgctg cagttgccaa gctcgccact 3108781 tcaacagtag acgaagaatt tggcgcactt acgcttcctg tagcagttaa cacagactca 3108841 ttagagcttg tcacagtttt gctctgatac gtgctcggat atgtcaacgt atttttagac 3108901 atataatctt gcaattcttt tatttttgag tttacttcac gatagctgtc acgctgccat 3108961 tcaagagtct gctttttttg tgtcagctta tcaagcggcg ctctttctgt ctgcatcagc 3109021 tttgatacga tatcatctat atccattcct gacgccagac ctgttattct tgtgaccatc 3109081 tcaaaccact cctattctac tttttttcat ctacaaataa cccaagaaat tcagtcatag 3109141 ccgcataaaa atcaagccac cgttttggtg gaatttcgcg gatcacttca tttgtagagt 3109201 cctctattac ctttacatag tattcattta acttgtcatg aagctcgaac ttcagatgaa 3109261 cttgcgaagg ttccaaaagc ttgttcattt cccccaccat ttcagcaaga ttggtatatg 3109321 aaacttgatg aacaggaacc tcgttatcat tatctttctg attatgtatt tgagtatcat 3109381 aacgatccca aacaggttgt aacgtagtga gcctttcaat gttcaattga tcatccccta 3109441 tgccccaatc tatcgtttat atcgactaag tcgagataag attacacata tttttggaaa 3109501 aaaatcttct gttttagatt tcttgtatgg aaatacattt ataaaaagtt agtggagaat 3109561 ccggttatta tatcatgagt tagtgacagg atgaggaatg attaggagat agaaatttaa 3109621 attaaaagac cctggcaacg ccaaggtctt ttttaaaatt aacgtaataa ttgaagtacg 3109681 ttttgcggct gttggtttgc ttgagcaagc atagcttgag aagcctgaga aagaatgttg 3109741 ttctttgtga attcgctcat ctctttagcc atgtcaacgt cacggatacg agactcagca 3109801 gctgtcaagt tttcaccaga agcgcttaag ttgttaattg tgtgctctag acgattttgt 3109861 accgcaccaa gcttagcacg ttgagaagaa acttggttga tcgcttcatc aacaactttc 3109921 aattgagcat cgaaaccgat atcagcagta tctgctgcat tatctgcgaa ttttgttacg 3109981 tcaagatcat taactgaatg aagagctgca attgaaccat cagcttcttt aattccaaga 3110041 gcgtcagcac ccatatcctc aatatttaca gagatttgct gtgtagcatt tgctccgatt 3110101 tggaatacca agttcttttg atttgcagga gtagctgtgt caactttgta agtgccatcg 3110161 agcaatttct taccattgaa ttctgtacga tttgaaatac catcgatttc atctgttaaa 3110221 gctgaaattt catcttgaat agattgcaaa tcagttgctt tgtcctgagt tccagtgttt 3110281 ccagcttgaa caactagctc acgaacacgt tgaaggatcg catgagtttc agttaatgca 3110341 ccctcagctg tttggataag agagattccg tcttgagagt ttttagaagc catttcaaga 3110401 cctctgattt gtcctctcat tttttcagag atcgcaagac ctgctgcgtc atctcccgca 3110461 cggttgatgc gaagacctga agaaagtttc tccatgttct tttggctcgc actgttgttt 3110521 gaagacaaac ggttcagtgt gttaagcgct gcaatattgt ggttaattct cattgttttg 3110581 ttcctccctg aatatgttgt taaggcacgt ccttgtgccc ttattttgta actggctgag 3110641 tcttttgcgc ctcctcccgg ctacatcatt aatatcggat tgtctctgat tttgttaata 3110701 caaaaataaa aaaatcctca ctttttttgt gaggataatg cggagatcac atcgctggat 3110761 aacgctgctg cacggttatt ttcttcctga atggtcaagt aaatttcttt cctgtgaata 3110821 tcaatatgct ttggggcgtc aattccaagc ttcacttgat ccccttcaac cgcaatcact 3110881 tttacttcaa tatcagcacc tatttgaatc gcttcgttta ttttccgcga taaaactagc 3110941 atgattctcc tccaatcgga tgctttgtcg tatatgagga gtcgtgtaaa acgacttgct 3111001 tagccatcat gttcttgcga ttcacaataa tgggagccaa taaattcgca gtagactttt 3111061 caaatggctc tgccatagtc aatattgtca tgacttctac gtcttgaata ttatcgatat 3111121 ccaaaagttc agcagttgat tcatcaagat caaattcata attcttaaaa aagataaacg 3111181 gacttacgac gataaacgca agattttctg aagtgacgga ctgcagtgcc acgaatggag 3111241 agtcttctga aagcggaagt atgacgaact gtttttcttc taaaaagcct ggaatcccgc 3111301 tttcaaaaag aatgatttgt tcttctttta tgttcatttg gccatggtac ttcgtatgaa 3111361 tgatcattgt tcacgatcct tttcttttta cttttcgggt gattctttcg ggtattctac 3111421 atctatattt aaatcagggt attgaagcat gtcaacctta acatttcctg gcgtatattc 3111481 aacaattggc ttatgcggct cagcctgaat aacaggcttt cgcggcgtaa tctgcacatc 3111541 aagctgtgac ggagtatatt gtattttcac cctcgaaaga gaaggagcat aattttcgcc 3111601 taattgaatt tggtgcattt cagagttcct ccttgcttgt gaagcgattg ggttcccctt 3111661 attttcaatc ttcataagct cgtcgccttc ttctgcagtg cgtgctattc cctccattac 3111721 atcctcatgc ccttgttggg cggcttcttc aattctcttg aaaacatgct ttctgtctaa 3111781 ttcttcccat gcttgtgtct ggtcaatcgt gagttttcca ggtgtcaccg atatttccat 3111841 ttccgcactc ggctgttcga tctctagatc agcttgaggc tgctccattt ttaagctggc 3111901 aggcgtcgtt gttaaaccaa tttttccttg aacactatgc ataatcaatc tgggaatctg 3111961 catcactcta cctcctgaac tataaaaaaa gcgaactcct aagagccgct tactttaaaa 3112021 agtcaatcaa tgtaggctga acaatttgcg cattaacggc cagagtagcc ctgtgcacac 3112081 tttgctgcgc aataaattca gttattactt cttccagttc tacatcttca ttgtctgata 3112141 acactttggt agctgtttct tcttgcgctg acagtcttgt attaaccagt tcaagacgat 3112201 tatatctcgc tccaagatca gatcgttcag cgctcatgcc gtcagaaaaa tgatcaatat 3112261 catttaaaac actgtccatg ccatctagcg aaccagaatt tagtgctttc tcaaaagaat 3112321 caagcatttc aaatacattc tgcccgcttt cagaagtgcc tccaaaagct gactttggat 3112381 ctgaattcac tttcaatgac atattatttg atatattgac tacgacatca gctgtatcag 3112441 aaattgtata agttccgtct ccgttatctg taaccggagg cttatctgaa tttgtgccat 3112501 taaagatata tctgccgttc acttgtgtat tcgcaatatt taaaagctgt tcctttaact 3112561 gctttacctc tacgccaatc gcttgccgct ccggctcgcc gtttgtatca ttttgagctt 3112621 caaccgctaa ttctctgacc tttgacaaga tgtcaattcc ttctgtaatg tttgtttctg 3112681 tgttttcgag ccaggtaaag gcttgagaag cattgctttt gtactgctgc acttgagaca 3112741 gttgcgtatt atactttaag cttttcattg ctactacagg atcgtcggaa gcttttgaga 3112801 ttttttttcc tgaagaaatc tgcgactgga gtttatccag cttcgagtag cttgaaccga 3112861 tatatctcag tgagttttgc tgtatcatgc cttgtgttac tctcatgtga ctctacctac 3112921 cttcctccaa cacccatgcc gttgatcact ttatcaagca attcgtcttg taaagtcacc 3112981 attcttgcag ctgcattgta tgcgtgttgg aattgaatca tattcgtcat ttcttcgtct 3113041 aaagaaactg cgctcatttg ctgacggttt atgtcagcat cattcagctg tgtttctgta 3113101 ttagacgcca gtcgattagc ctcttgagct tcgatcccta gctcgccaat cagacccgca 3113161 taataatcta aaacactagt ttctttaccg ttaatggtta ttttaccggt taaaacattt 3113221 gctaattttg tagcatttgc gttatcgttg gctgcgccag tcagtgagaa agcaatgttt 3113281 gcgccttttg aatctattat gctgtcagcc actttgatct tgcccgccgc gcccttggca 3113341 ggttcagttt caccgccagt aaaatcaaaa aagtctccgc cttgttcacc gctcttggtc 3113401 acaccatttc tgtgcacttc attgaaagct ttcgcgaatt caagcgccat attgtcaaga 3113461 tcagaaagca tttccgggta tacgcccttt tcttggccat ctgctgttat atacccataa 3113521 gactctataa accctaaaag ggatcccttg ctgctaaagg actccgcctg tacagctgta 3113581 tccccgattg aaatacttga tactaaccca gtttcattat catagttggc tgcaagttct 3113641 gaaacctcgt aatttttacc gtccaaaaca gttcctagcg actgtttatt tttatcaagg 3113701 atttcaattg atacagttcc ttcagcagat gcaagtgcat tcccgcctga tttgttgtag 3113761 ctgactttga tatcaaccat tgaggataat ttatcgatca gcaaatctcg ctggtcatat 3113821 aagccattcg gaagaagccc gaccggctct acttgtgcaa tttgcttatt taaactgttt 3113881 aactgagaaa gcagagaatt gacatccaac acagttgtat ttagctctgc ttttaaattc 3113941 gattggacat ttgtaagtga ttcagaaata taattaaacg tttcagctac agcttgtcct 3114001 tttcgagcaa caacagaacg tgcactttct tcatttgtat tattcgataa ttcctgcagg 3114061 gaattccaaa acgaattgag cacactgttc aagccgctgt catccgtttc atttaaaacg 3114121 ccttccattt gggacagcgc ttttgccttc gtgtcatagt atccggcact gttgttttga 3114181 agacggtatt ggtagtcaag aaagatatct cttattctct caactgattt tccttgaacg 3114241 cccgtaccca tttgtcccgc tgttttttct gcatttttag atacagcagg gaaatagtca 3114301 gttgcctcca atgagacccg ctgtcttgta taaccatcag tattggcatt tgccacgtta 3114361 tttgcagtag tgcttaacgc tgcctgctga gcgcttaacg cccgccttgc agtttcaagc 3114421 cccataaagg tagatgtcat tttctgaatt cctttctgct aagcttttga atcaaacagt 3114481 ttcattttgc tacttttcgg cagctcagct ttaattgatt tgctgtaatt gaagttattt 3114541 tccttaggaa ccagcatatc gtacgaaata gagatgaatt gcagcgcgtc tcttgtcagc 3114601 tgcctattca tctcatttac ttttttcaga cgtccgagaa cttgagaaag agattcgtat 3114661 agttgttcca gctcttcctt ttcactgcct gaggttttgg cgatacatgc ggaaatagta 3114721 ttattttcgc tatatccgag aaaggccgaa gttgttttga tccggtcatc ttctgtctgc 3114781 gtgattgctt gaatatattt ttgctctttt gtcaaaatgt tagaaagctc ttttgttttg 3114841 ccggctttga gcgcttccgt cttttcttca gacagcgtga gcaggtgctc atgcagaacg 3114901 caaagtcgct tcaattgttc aataattgcc ttcgctgaca tgggctttct ccttttttat 3114961 tgctttttat aaaaattaat catatttttc gcaatatgat ttgcgtctac tttgtatgac 3115021 ccgttttcaa tttgcgcttt aagctgcgca attttttcct gtcgtgaacc agtgactgcg 3115081 tcggatgcat gttgcatttc tttagcctgt gatgaaattt caattttatc ttgaggttgt 3115141 gcaacagttt tttgcaccgc ttgcttatca taattttttt gatatggatt aacggattgt 3115201 gttccaaatt gattgatttt cataggattc ctctcgcttt ccgttgcagt ctttaaacaa 3115261 tcttaaccct tttatcgact gcgttttcag ttagtttagg gaatcagctg tttttggtat 3115321 tataggcata gtatgtgtct tttttactat tttctttctc gattttcaga gcatcctcgt 3115381 ggttcaaatg atccatttga tccttaatat cagactggca agccttgcag aacttgcctt 3115441 ctctaatcga tgtcccgcac ctttcacaag ggtatgccaa attaggaaga tgagtgatct 3115501 gaattcgctt ctgcctgatg aatttcaata tcagctcttc ttccacacct gtttcctcag 3115561 ttatccggct caaagttgat tgccggtttt cctgttttct taaaaattta tagacagtct 3115621 caaatgattt ttcttcttcc ttaatacacg cctgacatac ggtttgcagc tttgttttta 3115681 aaaataaagc attgcatttc ggacaattag ccagttctcc catctttttt tctccttatt 3115741 agataatatg cctgtgtcaa tttctagtga ttatatcggc ataaaaacag aatcatttag 3115801 cttctgatca aggtaaaaga tgacactgaa gcggcttttc ctttttctaa taagcagcgg 3115861 gctgcgaagt gcaaggtggc gcctgttgta taaagatcgt ctattaaaat gatattcata 3115921 ccttctgctg aattattttt tgtatcaaaa atgcactctg acagcaggcg ttctgttttc 3115981 tttttctttg actgtttctc attattcagg cgaatgaggg gatggtggga aggccggtct 3116041 aaacattctg ccaagagatg tgcctggtta aatccgcgct cttcttcccg ttccttgctc 3116101 agcggaatag gtacaagaac aaaatgctta tcggggtaaa ccttagaaaa ggttgaagaa 3116161 aaatcacttt taaatgcatt tatgatttct gcatctcctc taaatttaaa acgggagagc 3116221 gtttctttca tcatatcatt atatgtgtaa actgaacggt tttgacgcaa tagcaaactg 3116281 tctctgatcc ttgttctcca cacctcgcaa tccctgcata cggcatgaac agattgaggt 3116341 ctgccgcaca gggggcagat atgtcctgtg attttcttta atttgcttct gcaagaataa 3116401 caaacctttt catcaggctt tagtaaaaaa agggctctcc atgtaacatc ttgagaaaat 3116461 tgcgaatcac ataataaaca gatcagttta tgaatgcctc ctcctgcttc gtttgacata 3116521 aatcgcttgg actctctgaa actactgcag cagattcagc caaaatgaca agcattgctg 3116581 tgtttttttg tttatctacc agctcagctt tcgtatatgc gatcttttta aaatcagtaa 3116641 cgtaggatgg actcactttg tttaaagaaa gtgccaatac atcgttttgg catacttggc 3116701 aagtacaggc catatgaagc tggtccatat atcggtcgag cagttctttc attacgattt 3116761 cttttgaatt gacaagcatt tttacagctc ctcatcatcg gttatatgag tatactgtac 3116821 cacgttttca aataatggct agtctgtaca ttcaactttt gctgccaatt cattcatttc 3116881 ttttatatgc tttcttgcat cgagcatact ctttgttttg ccgaagtgaa agtaaatgac 3116941 atcgccgtcc gcatattctt tatgccggcc ggttcttcct gcaatttgaa caagtgcgct 3117001 ttccgtaaag atagacgatt ccgctcctag tacacccgtt tgcaccttgg ggactgtgac 3117061 gcctctttcc agtattgttg ttgtgattaa tagatcgagc tgaccatctc tgaattgctg 3117121 cactttctcc tttctatgct tgtcttccgc gtgcacagat gcggttcggc aatgaacacc 3117181 tttaaagcac gcagcagcct tttccagaat agaaacggaa ggaacgaata aaaaaacagg 3117241 cctcccttct tttacatgaa actctatcca tcttttcacc gctggcggaa ttttatttcg 3117301 gtttaatttc ttcttccagt ttccacacca tacaaagcgc ggttcgggta aaggtttccg 3117361 gtggtgtctt gcggggatgc gaactgaatg taactgtccg ttcagtgctt ttctttttaa 3117421 ttctttagga ggtgttgcac ttaaataaac gagggtgctg tttttctttc ttgctttttg 3117481 aacagcgaat tgaagggttt gatcagcaga atatggaaaa gcgtcaactt catcaatgat 3117541 cataacatcg attgcatctt tatatcgcaa aagctgatgc gtagtggaaa tcataagcgg 3117601 agatagccgc cctttgtcat cgcttcctcc gtaaagcgct gaaatgtcag caccctgaaa 3117661 ggcagccttg agtcttggag caagctctaa tacaacatcg gtgcgaggtg ttgcaataca 3117721 tacacgcagt ccttgattta acgctgattc tataccagga aacagcattt ctgttttgcc 3117781 agcgccgcaa accgcccaga tgaggagctc ttcttttttt gatattgctt caattaaaac 3117841 attggcggct ttttgctgtc cgcttgaaag cttgccatcc catgtcagct taatagactt 3117901 ccagtttgat tcattttcct ctttccatga atataaagga acctcctcac tcactctgcc 3117961 catcatgaca caggaacggc aatacagctt attctttcca gatgagtgat aaaaagaaaa 3118021 ataccgctga tcagtttgtc cgcacctatt acatctatat ctccgtttat ttatggatat 3118081 agaattttca gcagtgatat atccattctt gatatgccat tcaatcatct catcggaaaa 3118141 tgagagctca gtcctgagca aatgacggct tcgaagcgtc tgctgcaatt cttttgaaaa 3118201 ggaactgttt ttttcaactg gcacattcac atagcacgcc tcctttcgaa acagtatgcc 3118261 tgaatgaata ttttctgtcc aactattaaa ataagaatat aaaaaaatct ccgctctaaa 3118321 aacggagatt tggccttatt taaaacacca gcaaattcct aacgcacctt cacccaaatg 3118381 agtgccgatt accgcgccaa aatagctgtt ataaaattca acatgaggat attttgcaga 3118441 aagctcttca atgattttcg ctgcttcttc ctctcgatta gcgtggataa cagcagctcg 3118501 cataggcaac cctttactcg catcttcgtc taaaagctca taaattcgcg aaattgcttt 3118561 tttacgtgtg cgaatcttct caaaaggcac aattacctta ttgtcaaaat gaaggatagg 3118621 ctttaccttt agaagactac caatgaaggc ttgggcgctg cttaatcgcc cgccgcgctg 3118681 aagatgggct aagtcatcta ccataaaata agctcgaact gtttttttca tttcttccag 3118741 ttcttttata atatcttccg gcgatgatgc tccgtttttg attaattcag cagctttaag 3118801 ggcataaaag ccttgagcca agcagctgat ctctgagtca aatggataca catcaatatt 3118861 gtcgaccatc gaatcagccg ctgctgcact gctgaatgtt ccgctgatcc cgctggaaag 3118921 atggatactg ataaccgcat cataagactt gccaagctct tcatacaacg caaccagctc 3118981 gccgattggc ggctgagaag tcgtcgggag ctcattatgt tttttcactt cttcataaaa 3119041 gcttttccag tccaactcaa tttcttcacg gtaagtctcc tccctaaaaa caacctggag 3119101 agggatcata tgtatctgat gttgttcacg catttctttc ggaatatatg ccgtgctgtc 3119161 tgttacgact gcaatattca tagcttcgat acctgcctta ttgctttata actctattgt 3119221 aagggaaacg gcagcctaaa aaaagacctg cctagtaaaa ggcaagtctc ctattatact 3119281 atctcatttc tacccagcca tttttaatgg cgaccacaac ggcttgcgtc cggtcgttta 3119341 cattcatttt ttgtaaaata ttgctgacat ggtttttaac ggttttctca ctgataaaca 3119401 atgattcacc aataccgcgg ttgctttttc cgtctgcaag catctgcagc acttcacatt 3119461 cccgcctagt taaaatatgt aatggtctgc ggatttcagg gtaaacctca tgttgagggt 3119521 gtgcagaaac tccgcttgtt gcaaggcggc ggaattcgtt aacgaggttg tgagtaacct 3119581 tcggatggag gtaagatccg ccctcagcca ctactttaac cgcttcaatt aatgtatcag 3119641 catccatctc tttcagcaga taacctcttg cacctgtttt cagggcatgt gttacataat 3119701 tttcgtcatc gtgaattgat agaataatta ctttagattc aggatacagc tctacaagct 3119761 gttttgtagc ttccacacca tttacgtttg gcatattgat atccatgatc acaacatcag 3119821 gatgatagtg ctcaacaata cgagccgctt cgtccccgtc atcaccttcg gctaccactt 3119881 caaaggtagg ttcaaaatcc aatatccgtt taacaccttc acgaaataac tgatggtcgt 3119941 cgataataac aatgtttact ttagtcacaa gccacgcctc cttgtattat tgttctatat 3120001 actctagcat tcggtcaata tgccttttgg ctctatttta caaatcatag tcaaagagat 3120061 aacggaacct taatcataat aaatgtccca agacctattt tcgaatctat tgtcatcgtt 3120121 ccttccaata aatctactct ttctttcatg cccagcaagc cgaatgattt gtttttcttc 3120181 tctttcgctt ccttcaggtc gaacccttta ccgttatctt ttatcattaa aatcacaaaa 3120241 tcctttgtga tctcaacttt gactgtaatt tcttcagatt cagaatgctt tagcgcatta 3120301 gacacagctt cctgtgcgag cctgaagagc gcaacctcaa actgaggcgc tagcctctga 3120361 tcctctgttt ctccaatgca ctgaaaatgt attttgacct tcccgttata ttcctcggtt 3120421 gtatatagat attttcttaa agttggaatc aggcctaggt catcaagggc catcggtctt 3120481 aaatcatata taatccttct cacttcgtaa agggcattcc gaacattttg gcggagattt 3120541 ttaatttctt ggaatccgtc ctctgcgccc cggtcacgga aaatccgctc gattaattcc 3120601 gatctcatca taacattcgc cagcatttga gcgggtccgt catggatttc tcttgagact 3120661 ctttttcgct cttcttcctg cgcctcaata attcttaagc cgaaatcctg ttttgcctga 3120721 gcatcagcaa gaagcagtcc aacttcgcgc aaatcctgat tcaagtagtt gagcacaact 3120781 gtaatttggc ttactaatga ttctgaccgc tcaatgattt cctgaagccc tagcaatctg 3120841 cgctccaaat cgtcccgccg ttcgcgcaat tgcttctcac gctgctggat catcgtcaat 3120901 tctacctgca gcttatgggc tttttcataa gcattgcgga tttcctcttc actgaatcta 3120961 tgaaaattac ggctgacctc ggataaacgg tttctcgcat ggcgagtttg cacttcaagt 3121021 ttatcgccaa gctcaatcac ttcatacacc tgctgtttaa tttgtttcag ttcttcgacc 3121081 agctgttcat actgctggcg tgactgctcc ccgatttgaa aaacctcgtc cttgctcccg 3121141 tcaacggttt tcagcatctt catcaaaata gaatccagca ctttggaatc catctttgtt 3121201 ttattcataa tttccctccg tcacggcgtt gtcatatatt tttattataa atgtaattga 3121261 tctgcaaatt atgtcgaatt ataatgaaag aatgcgtata ttctagaaaa aaacattttt 3121321 atatactatc tactctttat gataccaaaa tacgcacaaa aattctaaag actgtacgaa 3121381 tttgtatagg cagtctttta tgcttagcag gagggtcagc tagcatgctg cacagctatt 3121441 ttactgtgaa agaagcggga gaacacgaga ttgttataga aaaatcgcgt tttatctgtc 3121501 atttaagccg tgtttctacc gaacaagagg cacaggaatt tatacagaaa ataaagaaac 3121561 agcactggaa tgcgactcat aattgctcgg cttatgttat tggcgagaat gatcatatcc 3121621 aaaaagccaa tgatgacggg gaaccaagcg gtacagcggg agtgccgatg ctcgaggttt 3121681 taaaaaaacg caggctgaag gatacttgcg ccgtcgttac acgctacttc ggaggcatta 3121741 agcttggtgc tggcggatta attcgcgctt atgggaaatc agtgtctgaa ggattaaatc 3121801 atataggtgt tgtagaacgg aagcttatgc gaatcatgca tacttctgca gattacacat 3121861 ggcttggcaa gattgaaaat gaattaaggg agtcacaatt tctgttaaag gaaatccatt 3121921 attcagaaaa tgttgaattc gaaacatacg tggaagaaaa agaaaccaac gctttttctg 3121981 aatggatgac agaactgaca aatggaaaga gtgatattaa agagggagag ttgacgtatc 3122041 ttgaaaaagc cgtcaatcac ataaaggaga ctgaataatg gctgaacgcg ttagagtgcg 3122101 tgtgcgaaaa aagaaaaaga gcaaacgtag gaaaatttta aaaagaataa tgttattgtt 3122161 cgcccttgca ctattggtag ttgtagggct tggcgggtat aaactttata aaaccattaa 3122221 cgctgcggat gaatcgtacg atgccctatc ccgcgggaat aaatcaaatc ttcgcaacga 3122281 agttgtagac atgaagaaaa aaccattttc tattttattt atgggaatag aggattacgc 3122341 gactaaagga caaaaaggga gatcagactc tcttattgtt gttaccctgg atcccaaaaa 3122401 taaaaccatg aaaatgctga gcattccgcg tgacacacgt gtgcaattag ctggtgacac 3122461 aacgggaagc aagacgaaga tcaatgccgc ttacagcaaa ggcggtaaag atgaaacagt 3122521 tgaaactgtt gaaaacttct tgcaaatccc gatcgataaa tatgtcacag ttgattttga 3122581 cggatttaaa gatgtgatta atgaagtcgg cggtattgat gttgacgtgc ctttcgattt 3122641 cgatgaaaaa agtgatgtag acgaaagcaa acggatttac ttcaaaaaag gcgagatgca 3122701 tttgaacggc gaagaagcct tagcatatgc ccggatgaga aaacaggata aacgcggaga 3122761 ctttggccgt aatgacagac aaaaacaaat cttaaacgcg ctgattgacc gcatgtcaag 3122821 tgcaagcaac attgctaaaa ttgataaaat cgcagaaaaa gccagcgaaa acgttgaaac 3122881 caatattcgc attactgaag gtttagcgct tcagcagatt tacagcggct ttaccagcaa 3122941 aaaaatcgac acattgagca ttacaggttc tgatttgtat ttagggccta acaacacata 3123001 ttactttgaa cctgatgcta caaatctcga gaaagtcaga aaaacgcttc aagagcattt 3123061 agattatact cctgatacaa gcactggcac ttccggtacc gaagacggga ctgacagctc 3123121 aagcagttct ggcagcactg gcagcactgg cacaacaact gacgggacga cgaacggaag 3123181 cagctattcg aatgacagca gcacaagctc aaacaacagt acaacgaatt caacaactga 3123241 ttcatcctat taaaaaatgc ccggtccttt tagaggatcg ggcatttttg cgcagaaaaa 3123301 aactccggca cataagccgg agtttttaat tccttttcac cagccgttta taaaactttg 3123361 taaacggctt aaatttttca ttcacgagtc ctgtcacttc tgctatgatt tgcataaaaa 3123421 taatcaaaat gaagataata aacaaagaaa gccaaattgt ggcactttta agtacaatcg 3123481 cactgatact gaaaataaat ccaattaaat aaataactaa gaccgacatc cgatgtgaaa 3123541 ggccaaaggc catcagtcta tggtgaatat gcgacttatc aggcgctgaa atcggctgtt 3123601 tgtttaatat tcttctgatg atagcaaatg ttgtatcaaa aatcggtacg cctaatataa 3123661 taatcgggat aacgatactg aacaatgtga cacttttata caggcctaat aatgaaagaa 3123721 tcgagatact ataccctaaa aacagtgatc ccgtatctcc cataaagatt tttgccggat 3123781 ggaagttgta aaacaaaaac cccagcgtgc tggcaataac gactaatgag agtgacagaa 3123841 tgagcacttt tccgccggat agcgccatga cagcaatcgt tgacaggccg ataacagaaa 3123901 gaccggcagc aaggccatcc aatccatcaa tcaggttaat tgcgttcgtg atgccgacaa 3123961 tccataatac cgtcagcgga taagccatcc atcctaactc aaatcgttct gttaaaaaag 3124021 gtactgagaa aaagtccatt tttaagccag tgcttacaat cataatggct acacctaatt 3124081 gaatcaaaaa cttaactttt gcacttaatt gatatttatc gtcaagaata cctaacacaa 3124141 taatgatgaa tgctccgact gtaattgccg tcatccttgt ttctgtgtaa ataccggatg 3124201 caagcacgcc tgcaaccacc ccgataaata tggccagccc gcccatgcgg ggcatgattt 3124261 tgtcatgtac ttttcgattg ctgggctggt caactgcacc tattttaatc gcaatccttt 3124321 ttacgattgg ggttatgatt aaaactgtca gcagcgagac aataaacgca acaacaatgc 3124381 gaatcatgcg ttcgtcaagc ataaagaagt ctcctttgga attaaatgaa gtctttattt 3124441 atatagagaa ccgttccttc cattatacct tctccttagt tattataaca agcttcatca 3124501 aaaagaaaca cgtataatca aaaaacgcgc atcccaattt ataggactac gcatgttttt 3124561 gaatccctgt atatttcata atttgtctaa ataagcaatt ccaatcttgt gtccgggcga 3124621 tgtttcggcg catttcttta taggtctcgt ctccgttttg accgagaact ttttcacaag 3124681 cggctataaa atcaatcgga tgatcgccct ctacatattc gtatacatac ggcttttgca 3124741 tttttgaggt tgacggaaga ttagtgccta caacaggttt tcctgccgct aaaaattcaa 3124801 atagtttcag cggaaacaca gcttgattat acggtgattg tttatatggc ataatgccaa 3124861 tgtcgataag ctccatataa tgaggcactt cttttggatc tgccggaccg gtccatatga 3124921 cattgggaag cctcagcagc tcttgaaacg aaacatcacc attggtggca tccgggccaa 3124981 cccataaaaa tgtccaatca ggcttttgca gtgccgcttc tttaatcatt ttaaaatcga 3125041 gcttcggttt aatcccgcca ataaaaccta acactattcc ttctctcccc tgcagtatac 3125101 tgcgatcggg agcttgttta tttgcagaaa acagctcata ctccacaccg ttttccacag 3125161 tatgaacctt ttctcgtcct gcagtcagtt ttttgtctac ttccttgtga agataatctg 3125221 atgaacaggt tattgaatct gctcgttgta taattctcag ctctgccgat ttaatgactt 3125281 ttcgccggaa ttcagacagc agatttgatc ggccgctgat cggcgcagcc cataggtcac 3125341 tgcagtcata aatgacctga tcccaagaat acagcgaaga cagcagcggg aatccgggaa 3125401 acgtgtacca taaacagcag cgttcaccgt ttgcagaagc aggtgtaagc tcatcgagta 3125461 atggggagag cttatgtctg taaaagacat ctgtatatcg tccgaaacga aacatttttt 3125521 tctgcagcag gtctttgaca gcgaattgcc tgatgccaga atggacttcc tgaaactctt 3125581 tcccttgggc acgcggagcc ggacataccc aaataacttc cttcgtttcc tcctgagcag 3125641 ctaaaaattc tgccagccgg tgccttctgt atctcaattg gtcttttccc cattcagcag 3125701 tggcaacgat gacatgaatg attgcttctt ttgtttccac cttcatcacc ttttctctct 3125761 gtttgcagct ataatctttt tttcaccgcg ttttttgcat attgaacaaa acaccatgtt 3125821 gctttcataa aatgaagccg ttcgatctcc ctgtagacaa accacgtttt tttcgcagcc 3125881 ttccatttgt tgctggaaat tgaattattg acaagccgat attcagccag gcattcattc 3125941 attccatagg cagtaaatcc tttttttaaa agagacagcc atgtggctaa gtcctgtctc 3126001 gttctgatat tcggcatttg gatctgtccc gtttgctccc tgtcaatcat caccgtcaag 3126061 cagccgataa ttgtattttt cagggcgtca tcgtacgtca ggctttccgg cgcatgaata 3126121 aatttatcga gcggggtccc gtcctgcgcc attaagctgt agcccgtgaa agagaacgca 3126181 caggagcgct ccatcataaa ctcaagctgc ttttccagtt tgtctttttt ccatttgtca 3126241 tcactgtcca aaaatgctac gtagcgccct tgagcgcgtt ccaacgcttt gttgcgagca 3126301 accgcagctc cggagttctc ttccagatac accacatgaa ttctttcgtc tattttttca 3126361 tactgctgta aaatgtcgcg ggtcccatcc gttgagcaat catccacgat aatcatttcc 3126421 caatgaggat ggctctgatc taataccgaa tgaaccgtgt cttcaatata gtcacgcgca 3126481 ttataggaag gtgtaatgac agatacgaga ggtttccaat tggtcatgat cacatctcca 3126541 tcgtatgatt ttaaaaggat tctctgaaaa attcaggaat gacaacgaac ataaaggcaa 3126601 tcgtaaggcc aatcataacg ccgagaactg ctttcttttt cggagacata ccgccgcctg 3126661 ctgtctcact tacggtttcg gaatcagtaa cacttgccgc tttcaggtta agctgtgtgt 3126721 ttttgagttc atataaaaat ctctctttat ccactttgga atcctcgctc accgactcgc 3126781 cttcaagcgc gtctatgctg ctgcggatga cggcttctct ttctgcatac agcttttgat 3126841 cgtttttgag gaaggtggag gatatggcgt ttaagacaga ttccgttcta tccttatcct 3126901 cgtcactata gcttaaagtc agtaacgatt tggattccgt attgattgta agcttctctt 3126961 tgatctctgc tacatcttca tccttttcat caggaagcgc ctccttcaaa aaggagtcgc 3127021 tctttaatag aagcggaatc tcttctgtgc tgttataaac cggatgatca tagctcccca 3127081 cagccaaagt atcttcagct gtatagctct tttgatcagc gatctgtgac ggcaggatat 3127141 accccgccgc acctaatata attggcaccg ctatgatcca aatgatattt ttttttatgc 3127201 gacgggctat tcttatcaat atatcgttca tataagtctc cctgcttttt gtagtctgtt 3127261 tatctgtaca tcggctcagg catttgtctg gatcgcctta acacattcac ggcggcgatg 3127321 acgagcgcca taaacaccca atggaaaaat aaatttgaaa cagagcttgg gctgatactt 3127381 gataccagga aactgaccat agcggtaata agtccttctg tgatcagttt tgactgattt 3127441 tctaattttc tttcataaaa cttgtaaagc acccatatga ggtaggcata aacggacaaa 3127501 tatcccagca tgatgaacaa accaaaatta gcaagaattt caacaagcca gttatgcacc 3127561 tctgccacat tgtcagtatc atatacagca taatgctcaa gataatagga tacatttcct 3127621 gccccgactc cgaatccgta tgaatcaagg aaaaaatgcc aagcgttttt cagcagattt 3127681 gcccgagcca catttgatgg aagcctgtca tgaaatgaat gcagcgtctg cggggccaga 3127741 aacagctccc aaaactttga atagattttg ctggcgaaaa gaactgcgaa aagagcaatt 3127801 cccgccgccg acagccatat agccattctc tttaaaacag gcggcaatac aatgaagatg 3127861 tagacagcaa tacctgcaaa aatgcccaga aggctggctc ttgaaccagt ggcaaaaatt 3127921 aaatacaacg cacagagcga gagcacaagg ccaattgcct tgatgtatcc attcttaatg 3127981 tttttcatca tcgtgatgta aaaaaagaag ctgatggata aaaaggtcgc aaagtcattt 3128041 tgattaaaaa agaccgatgt cggataatgc tgcttgtact ccggtccgct gtacaatgtg 3128101 gaactcgcaa gatgatggtg ggtgatatga ttgtaaaaac caatgatcat cagaaatacc 3128161 gtcatcacca gccaaatggc ataaacaatc atcagccgct ccattttttg cacgtacatg 3128221 acaataagat aaatgaagaa gatccccatt gccaataagg ctaaatactt gaggccaact 3128281 gttaccgact tggcccacag cagagaaaca aggccatata taaaccaaaa ggcgaaaaag 3128341 agtaaaatcc cttttacttg cagcccatgc catctttcaa tatgggttcg attccgaacc 3128401 atgccgaaaa tatgaaggca acccgctgca atgagcagaa gccggtaaag gaacaaactg 3128461 aaaaatccaa gatgaatggc aaaaaatgca ttatttaaaa aagtgcaggc gatcaaaata 3128521 tagattacag ccataaagag ccgttctttt gttgtaaatg cggttgcaag cgtcagtaaa 3128581 aacaggccaa ttgccaacac cgcaagcaca gcagccatct gcatgaaacc tatatcttta 3128641 tggatggctc ccagcaatag gacgactcca aatatagcag cggccagtaa cgctagcgta 3128701 tggaccgctg atcgtttgat actcacatgt ttaacccctt tcctgatgtt tcaggagccg 3128761 gcggccgagc ctagcagccg gcagcttcaa ccaagtaaca ctttttcttt ttataaattg 3128821 acgcttccca agtctttagc caattcttca agcggcaagc ccggaaaata cttgtcagag 3128881 ggttccgttc cccgaacagc gggacggccg atagagtgat aaatgtatcc ggctgcctgc 3128941 atctcttcaa gtgaaaataa atttctgccg tcaatgatga ctggctgttt taagagggtt 3129001 ttcactttta caagctccat ttctttcact tccggccaat ccgttaaaat caggcatgca 3129061 tcagtgtctt ccatcgcagc atacacatct gtgtaatact cgacctgttc gccaaggatc 3129121 gctgaagctt caggaatagc aatcggatcg tatgctttta catgggcgcc cagctgctgc 3129181 agcattggga taatatcaag cgctggagcg gatctcacat cgttcgtatt cggtttgaag 3129241 gctaatccca ggactgaaat ggttctccct ttgacgcttc ccataacagt caaaagttta 3129301 tctacaatat gaacacgctg cttttcgttc gtttcaatga cagcttcgat gagcttgaat 3129361 ggatagcctg ccgattttgc gatttgaagc agcgcggttg tatcctttgg aaaacatgaa 3129421 ccgccgaatc caataccagc tttaaggaac tttctgccga tacggctgtc aagaccaaca 3129481 ccatcagcaa cttttgaaac gtctgcgccg actcgctcac aaatgtttgc gatatcgttg 3129541 ataaaggaaa tctttgtcgc cagaaatgca ttcgcggcgt atttaatcat ttctgcactt 3129601 tctaggtttg ttttaatgac aggagcatgg aatggctgat gaagttcctc aatgatggca 3129661 gcggctttat gacttgttga accaatcacg gcacgctcca tattcatcgt gtcatgaatc 3129721 gctgaccctt cccgaaggaa ttcagggtta gatacaacat caaatgagta tctccccttt 3129781 gaggcttttt gaacgataga ttgcaccagt ttccctgttc caaccgggac tgtgctttta 3129841 tttacgatca ctttgtagcc gttaagatgc tcaccgattg ttttcgccgc cgctttgacg 3129901 tacgttaaat cagcttcacc tgttttggac ataggcgttc cgactgcaat ataaataata 3129961 tctgaggccc gaatggcaga cgggatatcg ttcgtaaagg tcaggcgctg atccagcaca 3130021 tttttttcaa ctaagtctgc aagccctggt tcatagattg ggattacccc atttttcagg 3130081 cttctgattt ttgattcatc gatatcacag caaacaactt tattgccgat ctccgcaaag 3130141 caagtgcctg atacgagtcc tacataacct gttccaatga cagctatttt tttcacagcg 3130201 ctcaaccctc tcctgtaaaa tgatcttcca atttataatg gtcgcagtgt cttacgatta 3130261 aacggacgtt ttcgtgaccg tctgatactg atgatgcaag gccttggcgt tttttcctgc 3130321 gtcaaattga gcctgcacgg tttcatacaa gtcatctgct acttccggct tccatatttg 3130381 ctcatgttcg taccgagtga tcgcttccgc caaggcttga gcggatttcg gtttaatcag 3130441 cagatgttgg tgctttccga ataaagacga cactccgcca acatccgtac aaataacagg 3130501 aacccttagc gccagcgcct caatcacaac agtcggcatc ccctcactgt aagaaggaag 3130561 tacgaataga tctgccgcaa gtaaatagtc tcttacctga tgattcggga cttggcctgt 3130621 gacgatatgc cccttctgcg tcagcgtcga ttttgcggga ccatccccga caaagactgc 3130681 cttaggagag tcctgcagcg attcgatcgc ttcagacagt tcaaaaatgc ctttctctct 3130741 gaccagccgg ccgacataga cagccagacg ctgatcgagc gggagtccga gtctttttct 3130801 gatttcctct ttcgtctcct cattcccctg aaaacggctg agctgtatgc cgattggcaa 3130861 aaccgagctg tcaaagcccg aaagcttttt ggcttcttcc tgaagcttgt ggctgactgc 3130921 taaaacaact gacgcagaac ctacggcacg cttgaaggct ttaaacgcac ctttgctgta 3130981 atgcggatag acattcacat cactgccatg caaggtcagg acataaggaa tttgcgctga 3131041 ctctgacacg actgccgcag ccccgcccga tggcatggca aaatgcgcat ggatcagatc 3131101 cggatatagg tcgcgctgtt tcattgtttt taaaacggct gatgcgattc tccgatgagg 3131161 ctgcgcccac ttcagctggc cgggaactgc ccgatagaaa ggccggtaaa ccggtatccc 3131221 ctttctaatc tcatactccg gtctgacatc cttttttcga tatgtctttt tcagcatgcg 3131281 gacaggtgct gaatgaaaag gccgtgggca tatcacagtg atatcaagcc cgagtttttg 3131341 cagctcttgc acctgtgtct catgaaacac accctctccg ggtttcatac tgctcggata 3131401 tacgcttgtg atccacaaaa tcttcatgac aaacgtcctt ttcttagtag tttgcttttc 3131461 gtttgagggt acgcttttac caaaagaaag agatagcaca gcgccccagc cgcaactgaa 3131521 atggccagcc gcatttctgc ctgcatactg aagtgttcgg tactgaggct tacaccaaac 3131581 gcgatgatgc ccatcgccgc agtaatcaga aatggcttca taatcgactg gaaataagct 3131641 gaaaggttaa gcttgatgac atatgccaaa agccagcgcc caatcaggaa attaacaacg 3131701 ctgataatgg catacaccca tgcgactgtc agcaggcttc ccgtctgtac agctgcaaac 3131761 agtgataatc cgtacagcag cagcacgccg gaatcccaat aaaacgctaa gtcagctctt 3131821 cctttagcca gcaacacaga tccatttgga ttcatgagca ctcttagtat tccgacaatc 3131881 gcaagaacat ttaggatcgg aacagcagca agccattttt ctccgaaaac cgctgtgata 3131941 aaggcgtctg acacagacac gagcccgatt aacagcggaa acgaaacaag cgccagcatt 3132001 tttgtcatat tcagaaagcc ttctctgatc acgctgtttt catatttgtt ttttgcgaaa 3132061 atagggaatg ccacccgtgt gacaatcgga ttgatcttca aaaccggaat ggtgacaatc 3132121 tgataagcga ggttataaat ccccaatgct tcagcaccaa taaaccggcc gatcaaaatc 3132181 atgtcgatat ttgctcccag cctgttcaca agacgggatg aaagctgaaa ggctccaaaa 3132241 gaaaagaaat ccttcatgcc tctcaaatca aaaacaaaag caggatgcca cttttttcgg 3132301 tatacagccc aatataaaat ccctttactg gactgcagca ggacttgaga aatcacgtac 3132361 gccaaaatcg catccatcat aaaaaccgct atcgctaaat atccgaatga caatacattt 3132421 gaaaaaatct ctattttgct taacgtatta aaatgcagct gcttttgcag catatactga 3132481 tattgctgtc caattggcgc gatcaaaaac ataatcgcca gaatccgaac cagaaacacc 3132541 agctcttctc tttgataaaa tcccgcaatg acaggactgc tcacatataa aagaacaaac 3132601 agcaaaacgc ccgtcataat gttaagccaa tacaatgttg acagctggcg ctccgtcgcg 3132661 tcgtctctct gaattaatgc tgcgccaaaa cccatatcga gcacaatctg ggcgaaaact 3132721 gtaaccgttg tgatcatgcc gacaagccca aattctgtta aggtcatcat atttccaagc 3132781 agggcaaact gaacaatttg tatgattgta atacacatgg ttgaaatact tgtccacttt 3132841 gcaccgctca tgatttgttt tgtaatactt ggcatcatat tccctacttc tttttaagct 3132901 cagattgatg gtgaataatg gaatcccgtt ttatcttgca ccatcacccg tccaaactac 3132961 tttacaagtt tttaacataa tttttaattc taaagtgaaa gtcagattgc gaatgtaata 3133021 taaatcaaat atcagctttt ccttcggcgt catatcgtaa ccgccgttca cctgagccca 3133081 gacgctgtgt aaagcctgga atctcattct ggaatttttc cgtaaatacg ggccgttccg 3133141 gacgagggcc aatcatactc atatcgcctt tcagcacatt aaacagctga ggaagctcgt 3133201 caattctcgt tcttctgata aaagctccga tccttgtcac ccgcggatct tgcttctgtg 3133261 cccaaaccgc cccagacttc tcggcatcta ttttcatgga acgaagctta taaagcttaa 3133321 atggcttccc gcctttccct acgcgttcct gcgtataaat ggcaggcccc ggcgtctcca 3133381 aacaaatcaa aattgaaaat accgcaatca ttggcagcgc aatcgccaat ccaatgagcg 3133441 caaaccaaat atccattacg cgctttattg ccaaataacg agccgtcttt tcagataatg 3133501 taaaagaatg tatttgttga actgagaatt cacgactcac attcatgctt ttctctgcac 3133561 tcactgacac acacctcacg atttgtttgg gatgttatga tgacctatgc cagtcagttt 3133621 agcagacgga tgttaattgg atgtaaatgg tatgttaaga agtgtgaatt acgtgttttt 3133681 tctgataaat gttgttaata ctcttttact attttatata caagtcctat ttgttttaat 3133741 catttcatat aaaaaagaga caaatctgtg attagatttg tctctttcga ttatctgtaa 3133801 taagatactg tgccgtcatg aatagcttgt gcagctttat ctttataaac cgcttgcttc 3133861 aatttacttg catctgatgc attagtgata aaggcagttt caactaaaac actcggcatt 3133921 ttagaatatt taataacata gaaagcagct gtttttactc cccggtctct cgttccaaga 3133981 ttagccgcta actttggttg aatttgttca gccagtctct tgctatttgc agcttgatat 3134041 gttgtatcgt agtacgtctc acttccattt ggtgatgagc tatcattagc atttgcatgt 3134101 atactgagaa ataaatctgc ttgtgcagaa gctgctttat ttactctctc ctgtaaagaa 3134161 taaaaagtat cattagatct tgacagtact ggaagagcac ctgaagcatt tagctttgta 3134221 ttgactcttt tcgctatatc aaggttgact tctttctcaa ggagtccatt gccgattgct 3134281 cctgaatctt gatcaccgtg acccggatca ataaagattg tttcacctac aactggattc 3134341 tttagctgat tagcaacctt tgtgcttacg gcaggagtgt ttccgataat cataaagttt 3134401 gacatgtttt tacttccaat aattttacgg gctcctgtag ataaattttc accatttgta 3134461 agaataagag attgcttctt cttagctgcc agtgtagctc ctgcaataga gtcagggtag 3134521 ctgaatccat tgcttacata tacggtgctt gttgataaat taagtttttg tacgatattt 3134581 gcagcaagct catatctgtt tgaaccgcta attcttgtag gagaaggtaa cttgttgtat 3134641 accgtattgc tgatacttcc agtgcctcct acaacaacgg tactcgaaat tcccttatct 3134701 tttatcacag acgtagtcgc actatttata gatgttttat ttgtaaaaag aattggatac 3134761 ccgtttttcg ctgcataagg gatgacggcc ggagcgtctg catataagaa gccgttcaaa 3134821 ataacagctt ttgaagtcgc acccatcgct tttgccaccc gtgcagccgt atcataacgg 3134881 ttgcttcctg caattcgttt aatacttatc cccaagcttt taatctggtt agcagtgtta 3134941 gaagaaacag caggtgttcc gcctacaata attacatttt tagtctgcat ctctttcaat 3135001 cttgttttcg tttcatatga aagcttatca gaattagtgt aaagcaatgg cgcattcttc 3135061 tggtaagcaa gaggtgctgc tgaaatagca tctgcatagg aactcccacc aacaattaca 3135121 gctgtacttg ctgttgaata catttgcttt gatatttgta cagcagtgcc gtatctattg 3135181 cttcccccaa ctcttttcac tgagttatcg gccaaagctg ttggcacaaa aagtatgagc 3135241 cccagaaaac acattgttag gacttttata taagaacgca attgatttcc tccttaaatg 3135301 gcgttatatc ctaaaataat caataacttg tcagagttgt acctggatag taaaatttca 3135361 aaattgaact atatgaatct ccagcttctg ctcttgcttt tgctccatat tgactcattc 3135421 cgatcccgtg accatatcct ttaccgctga ttgtgtactt tgaagtatct ttttttacag 3135481 tcacataagt acttttaaat acagtcgctc caatcattgt tcttaactca cttgttggta 3135541 cactaatggt tgtaattttg ctcaagttat aggagccagt actgctttta acaaaatact 3135601 tcactttcat cgatgctgtt tttgcacgct gcccttgtgt cgttccacta aagcttaaat 3135661 cgtcaatact tgcaattttg acagaatcag cgcttgtttc tttatttttc aagatccagt 3135721 tcttaactcc ggaaagtctt gcagaatcag tttcagtcgc tgaagaccac caagaagaag 3135781 gcttcgttaa gtccaaagat ttcgtatcta gctgttgttt tgacaaagta agcgtccagc 3135841 ctatttgagg atcctttgta tctttttttg caatcaagta aggtacactt gacgaccaca 3135901 cttcattact agcttctgtg taaccaccat tactggaaga ataagctgca gttataagag 3135961 atccattata tttcagaact ttccccttcg tttgctctac cgctttattg gtattcgaat 3136021 tccaactgta gccaccataa acttgaaaag cggttgtatc aggtacagta gttcctgttt 3136081 ttgttattga gtaggttctt gcagcgacag tctgtgcttt aagagcctca agtgaccagc 3136141 tagcaggcat ttcattcgga attactcctt ttaagtaatc ctcaaatgga atattctcat 3136201 ttaccggtcg gatatattta gtagactcaa tagagaaatt aaccgtgcca agatactgct 3136261 ttccatcaag actaattctg tttgaagtag aatagttttc tggtttaatt cttagggagt 3136321 ttccgtaagt tttgatgttt tcaaggttta attttccgct gttgattttt agattatagg 3136381 tgccaccgtc agctaaataa aattcatcag caagtgaatt ctcaacttca gcagaaattg 3136441 aactggtact tccaataaag tcgtatgcat atgtggcttt atctttcgtt atacttttag 3136501 ccgcagccgg aacgctatct tgtttaacaa ataaaatttg gctgtttttc ttcgaggcaa 3136561 gcgaagcgcc tatcaatacg tctgcatatt ttgtcccgtt cgtcattacg actttatcag 3136621 ccttcaactt tagttgctta attatatttg ccgtaagttc atatctggtt gatccaggaa 3136681 tcctttgcac agttgaagtt tttttaattt ggttttctac actatcactg acgctaaatg 3136741 aactgcctat aatgatgact tgttttggca aatcataatc cggaagcttg tctttctctg 3136801 taagcaaaat agggtatccg tgtgctgctg catatggagc aatggctaaa gcgtcttgaa 3136861 atactcttcc ggttacaacg atcgctttat catagctgcc catttgcttt gcaatatttt 3136921 ctgataagac atatctattt tttccgctta tccttttcac agcgccatat gatttcagct 3136981 tgttttctac gtcttttgaa atgcttcgcg ctcccccaat gattaaaata ttatcagggt 3137041 taaacttagc aatttgtctt tcagtagttt ttgttaacgt gtcaggctga gtaaataaaa 3137101 ctggtgcgtt cagttttttc gccaatggaa taacaggcaa tgcatcaata aaaatatctc 3137161 ggttcaccaa tatcactgta ttaggatttt tccactggct gttggatgca agagtcgcag 3137221 tttcgtatcg tgaagcgcct gcaaaacgat ccgtaacagc aacattatct ccagttactt 3137281 tataaaatcc tgttggcgat agactgatgc tagatttatt tccaatataa tttaacaatt 3137341 taactgagat gtttgagtct gctgcaaaag aaactgatgg aatcaataat aagattgcag 3137401 caagtgaaca cactatcaat tgtttgcaag atttcaaaat ttcaggttcc tccctatatc 3137461 ttagttggca cgttcaatat cttttaacag aagctgaccc tcatcatttt tttcatatgt 3137521 aatcgtgacc ttatctccac tgttaaactt atcaagatca cttgtcgatt cttcagtgat 3137581 atcaagacta accggctcat tatctactgt tacttctatt gtatgagtat cagctaaccc 3137641 tacataagta ccttcttttg tttcaatgtt actgtctggc gatacatctt caccttgact 3137701 cttttgacta ttaaccccgc aacccgaaag aagcaatata aagaacagta aagcaataaa 3137761 ttttttcatt tttttcacct cattatattt tatcgtcaac ctattttata ttttaaagaa 3137821 aaattaagaa acaatgaaac ttttttttat aaaaaacgac tattttagga tttcattctt 3137881 gtattaaata gagttgtatt tattggaaat ttaactcata atgaaagtaa tttaacagac 3137941 gaggtgcaaa ggatgagaaa cgaacgcaga aaaaagaaaa aaactttatt actgacaatt 3138001 ttaacgataa tcggacttct tgtactcgga actggcggct atgcatacta cttatggcat 3138061 aaagcagctt caaccgtggc aagtattcat gaaagcattg ataaatctaa aaagagggat 3138121 aaagaggtca gtatcaataa aaaagatcct ttttccgtct taatcatggg tgtggatgaa 3138181 cgcgacggcg ataagggccg tgccgatacg ctcatttata tgaccgttaa cccaaaaacg 3138241 aatacaaccg acatggtcag cattccgcgt gacacgtata caaaaattat cggaaaaggc 3138301 acaatggata aaatcaacca ttcatacgct ttcggcggca cacagatgac ggtagacact 3138361 gttgagaact tcctcgatgt tccggttgat tattttgtga aagtgaacat ggaaagcttt 3138421 agagacgttg ttgatacact tggcggcatt acagttaaca gcacattcgc gttcagttat 3138481 gacggttatt cgttcggcaa aggagaaatc acgctgaacg gaaaagaagc gctcgcttat 3138541 acccggatga gaaaagaaga tccgagaggc gacttcggac gccaggaccg ccagcgccaa 3138601 gtcatccaag gtattattaa taaaggcgct aatatttctt ccatcacgaa attcggagat 3138661 atgtttaaag ttgttgaaaa taatgtgaaa acgaacttga ccttcgataa catgtgggat 3138721 atccagtccg attacaaagg tgcgcggaaa catattaaac agcacgaact aaaaggtaca 3138781 ggcacgaaaa tcaatggaat ttactactac caagctgatg aaagcgccct ttccgatatt 3138841 acaaaagagc tgaaggaaag cctcgaaaag taaaacaaaa agaagcttcg cacaatgtgc 3138901 aaagcttctt ttttatttgc ctgtaaatga atccggttgt tcttttcgat acccgtaatg 3138961 aaacagcaat tcttccacaa tccggcggga agcctctcca tctccatacg gattagaagc 3139021 ctgggacatt ttcttgtact catcaggatc agttaacagc tgttttgcaa gctgataaat 3139081 gttttcctca tccgtacctg caagtttcag cgttcccgct tccactcctt caggccgttc 3139141 cgtcgtatca cgcagaacaa gaaccggttt cccgagagat ggggcttcct cctgcacgcc 3139201 gcccgaatcg gtcaatataa aatgcgattt cgctgcaaag ttatggaaat cgatcacctc 3139261 taaaggttca atcagatgca ctctgtcaga atcaccaaaa tgcttatgag ccgcttcccg 3139321 gacaacagga ttcaggtgca cagggtaaac gacttgtaca tcttcaaatt cccctacaat 3139381 tctgcggatg gccttaaaca tgttttccat tggctcaccc aaattttccc ggcggtgagc 3139441 ggtcaagaga atcattttat cctcacccac ctgatcgaga acaggatgtg agtaaccatc 3139501 cctaaccgtt gtgttgagtg cgtcaatcgc tgtattgccc gttacaaaaa tagagtcggc 3139561 ctttttgttt tcttttaata aattgtcttt cgcctggcct gtcggagcaa aatgcaaatc 3139621 agcaatcgcc cctgtcatct gtcgattgag ctcttccgga aacggggaat acttattccc 3139681 tgtacggagc cccgcctcca catgaccgac agcaatttga tggtaaaaag cggctaggct 3139741 tccggcaaac gtcgtcgtcg tatcaccatg gacaagcaca atatcgggtt tgatatcttt 3139801 aaacaactca tccaatctta caagtgcgtt agacgtaatc tctgccagtg tctgccgctc 3139861 cttcataatg ttcaaatcga agtcaggctt gatgtgaaac gcatctaaca cctgatcgag 3139921 catctgtctg tgctgtgcag ttaccgttac ataggaatct atttcaggat attttttcaa 3139981 ttcaagcaca agcggtgcca tcttgatcgc ttcaggcctg gtcccgaaaa cggtcatcac 3140041 ttttagtttt ttcatatttg tcacctggtt ttctgctata gtaaataaat tcatactaca 3140101 tattctacat gaaaatgcat cattttaaat catttcattc ttgattcaaa taaaatgata 3140161 taagttttaa tattaaggat aaagcttgtt taaaaatggt ttatccgata tcataaaaat 3140221 gtgtaaaaac atattgaaaa gggtaaatag agaatagttt aaccataaat tttttcgatc 3140281 ataaggaagg tgccttttaa atgaaaaaag tacgtaaagc cataattcca gcagcaggct 3140341 taggaacacg ttttcttccg gctacgaaag caatgccgaa agaaatgctt cctatcgttg 3140401 ataaacctac cattcaatac ataattgaag aagctgttga agccggtatt gaagatatta 3140461 ttatcgtaac aggaaaaagc aagcgtgcga ttgaggatca ttttgattac tctcctgagc 3140521 ttgaaagaaa cctagaagaa aaaggaaaaa ctgagctgct tgaaaaagtg aaaaaggctt 3140581 ctaacctggc tgacattcac tatatccgcc aaaaagaacc taaaggtctc ggacatgctg 3140641 tctggtgcgc acgcaacttt atcggcgatg agccgtttgc ggtactgctt ggtgacgata 3140701 ttgttcaggc tgaaactcca gggttgcgcc aattaatgga tgaatatgaa aaaacacttt 3140761 cttctattat cggtgttcag caggtgcccg aagaagaaac acaccgctac ggcattattg 3140821 acccgctgac aagtgaaggc cgccgttatc aggtgaaaaa cttcgttgaa aaaccgccta 3140881 aaggcacagc accttctaat cttgccatct taggccgtta cgtattcacg cctgagatct 3140941 tcatgtattt agaagagcag caggttggcg ccggcggaga aattcagctc acagacgcca 3141001 ttcaaaagct gaatgaaatt caaagagtgt ttgcttacga ttttgaaggc aagcgttatg 3141061 atgttggtga aaagctcggc tttatcacaa caactcttga atttgcgatg caggataaag 3141121 agcttcgcga tcagctcgtt ccatttatgg aaggtttact aaacaaagaa gaaatctaaa 3141181 caaaaaggct attggacatt catccaatag ccttttttta tttcaacatc aaagtcaatg 3141241 tatgctcttc attatcaact gcgaagacct gatcaacggc ctgccgcaaa aattaataat 3141301 cccagacaaa cacactgatt gtagagttaa acaaactaaa tgaaaacata aatacaaaca 3141361 tgcagattaa atagtaaata tcttgtattc aatgcaagct aagtaaacac cacttgctaa 3141421 aagaacaatg actaaacaac cagcattaca aaataattaa ataaatttga agcaattaca 3141481 acagaaggca gtgaactgtc ggaaagttca ttttggctac catattaatc cctttaacta 3141541 cgctgttgga tttatcaaga attgtcgggc taatagaaaa ccacggaatc aaaccagcca 3141601 gcattcaaac gataaaaggc acttctccga tacctgttat gaccagctta ctgttgcgca 3141661 tcccaaatac aaaccagtac gccatcatta gaataagggg atttaaaacc tgccataata 3141721 caccaaaata attgattttt tggatctttc ggttaaagaa atttaaaagt accagtgaat 3141781 attgtaacaa atgttgagtt tttttcactt ttaaaaagta aagagaagtc tcgcagaact 3141841 tctcccaaca tttgaagtgt caatataaaa caaaccaacc tcatttagca actttattat 3141901 tatctaattc caaaatagca ttataaatac gattcctatt atttttatca gtatatgcaa 3141961 aaaagttatc tactcttttt ctatacttat cttccatacg actattgttt ttcatataat 3142021 agataacttt atccactaag ctattatgat tttctaatac atcaccaaac cccatttttt 3142081 tataatcata ataatcaagt ttaaaatggt atgacttttc gtattgataa taaataacag 3142141 gttttttctc atatgcaaaa tcaaacgcaa cagatgaaaa atcagtaatc attatattag 3142201 aagaattaaa tagcatttga tagctgctgt tatagtcggc aaactccaca taatcatgct 3142261 tttcaaagtc tacaatctgt tgctgaatat ctgggtgagg aaaaaaagtt attttataat 3142321 tatttttctt agcaaattcg attagccgtt catcattaat caaagcatta tacctagaaa 3142381 aatattcact atctttaaat ttcgggttgt acggtcttac tccttttgcc tgatctttcg 3142441 gtaatacaat atcttttctc caagtcggca ttattagaag ttgcttttct ccctcactct 3142501 tcttaagatt atcgtatctc ggaaatccac ccaacaaaat attctctttt ttatagttgt 3142561 aattcccttt cacaatagac cgatattcag gtttggcaga agtgactaat aatttgatat 3142621 tcttgttgta tttgtttaac cattcagaat gatctgccat tgttattccg tgctgtaaaa 3142681 agataaactc aaagttaaat aaatctctaa aataaatctc catattaaaa aatggattta 3142741 caacccatat atctgcatgt gtcgatatta ctttggaaga ggataaggtt aaaattttat 3142801 gtctaaaaga tctgtatggt atgacctttc catatttttt gattctgtcg taatccttgc 3142861 tatctttttt tattataaag tattttttta ccccatcatt cttgttgatt gcatatttaa 3142921 agaggtgctc ggcattatca tcagctttgt cttgtctgtc tatgaataac catactggtt 3142981 ttctattaaa aatagtgaaa acatggtgta ccattcttgc catcagtgcc ttcttaatcg 3143041 ctgattttcg tttttttgat ttttcccctg atttatgtag ggattttaag aaacgaaact 3143101 cttttataaa tctattttta aaattgtttt ttttgaacat taatttttta taattataat 3143161 aaaaaatata atctttttta gccacataag tattatataa atcgtttgac aaacctgaat 3143221 acttgaaaaa acgaagtttt gtcaacttcc tttttttacc cttagttata aaaaactcaa 3143281 tatgatgatt atctgctaga tgacctttgg gaatatctat tgaaaaaccg ggatattttt 3143341 ttattacttc tcctaaactt atataatcat tatgctgtct ttttatattc tttgctttta 3143401 tttttgtttc gccaatttta gcataaaact taaaaccttt agaattaaac agcgagctcc 3143461 aaaagccttc tatgtgaatg gaatcctcat tttcttctaa aatttcaata gttaaagttt 3143521 gatccgataa tttcgaaaca attttacctt ctctgtataa ataataatcc tgttcagttt 3143581 ctctttcata tacataccta ctataatttt caccgtgctt tatttttaaa gcatgatata 3143641 aatagaaatg gctgacactt tttgtttcaa tgatgacatc gtcgtcaata tacgacaata 3143701 cttctcgaat caatgttaaa aattcactgt attcattttc gtctaaaggt gtttcactga 3143761 tatccttaat caataatttc cacttcaaat catgcataac catatattga agaaataaag 3143821 gtattttctg ttcatgattt tttataatat cgattaaatt ctttgagaaa gtgataagtg 3143881 aatggttaaa ccaattctta tttgctttag cagtctgcat ggcagatgat ccatcttctc 3143941 taactctata atggtatttt gcctctttaa ccagaccata ctttttcttt tgcgatatga 3144001 ttaaattaac tagtttggca tcttcaccta ttttacaatt ttcatcaaac ctgatatttt 3144061 tcaaggcatc tttttttata aatgtagaac aacaatgagt taatatatga tgcggttctt 3144121 tttctacatc caaaattctt gtagaagaaa acttattatt tagattatgt tctccagttc 3144181 ttccttctgc aaaaaaaata gggattgcta caatatcaat ttcattctta tgttcgtcaa 3144241 agaagtttaa aacattttcg aatgttcctt ctgaaactaa atcatccgga tccaaaaatt 3144301 gaatatatct accttcagca tactttaaac cataatttcg agcactgctc actccgccat 3144361 tctgtttctt tgcatagaca atgttattgg gatatttctg agcatattct ttacaaatga 3144421 tttcactttt atcggggcta tcatcattca ccagtattaa ctgaatattc tcaaaaccaa 3144481 tagtttggtt aatgatactt tctatagctt cagtgagata caactcaaca ttataaatcg 3144541 gcattataac actgaaatca tagttaaaac ttttttcgtt cataaaagat tactcctaac 3144601 ataatgttta tatgaataag aattcgggta aataaaatta agaaacaaga gagtactaat 3144661 ttttgcaaaa caattttaat ttagtaaaat gtatgaaaag cattccttac ctttttttaa 3144721 aaacccttgt aagcaaactt ttaaaaatgt tcacatggtt aagttctaaa gaatcatttg 3144781 gtgtttttag tacaaagtca aatgcaaagg cccaaatcgg tatttcgaca acaaaaccag 3144841 catatctaaa atctcttaat ttatatcccc atacttcaat tgtttttttc agttcttttc 3144901 gtttgcattt ttttaatctt ttaaaatatt ttatatatat tctgtcattt tctttcatct 3144961 cataatactg gttaataaag tgccctgtta attcaagtct aagccctttt atttttgccg 3145021 aagtaacagt acatgaacta tgcagtactc tttctttttt tatattttca agagcttctg 3145081 tattttcttt taataagtga aacataaatt ctttatagta catcggcata tcttgttctt 3145141 ttataaattg cgggtcaata aattttaaaa ctttaataaa atcatcaaca aaaactcttt 3145201 gttcttgttg atctaaaaca gacttataaa catctctata gttcggatat aaaaacagtt 3145261 ttatatgata tacaattaaa aattgcaaat aaggcaaaac tatatcatat ttgttgaatg 3145321 aatccatcaa caaagtcatg taacattcat tcaacaaata tgtgtacctt tttttgttaa 3145381 accatgaacg atcaactaaa gaatcctgtt ctttccgttt tctataaaaa tactttcctt 3145441 ctgcaactgc tccgtatctt ttttctttca gtaataactg gttaaaaaag atagcgtctt 3145501 cccaaaactt tatagattca tcaaaaagga cggtactagt tagtgtatgt cttctgtaaa 3145561 aagtgccgcc aatataaaaa tgaatagctt tataatcgtt gagaatattt ataactcttg 3145621 ttcctttttc aaatctatta tttaatttat gtcccccttc tttttcacct gtgtaataaa 3145681 caggtaatac cgcaatattt acatgttcgg aatcacaaaa aaaatcataa acactttgca 3145741 gcgcattttg agagaatgca tcgtcagaat caagaaaacc aataaattta gatctttcgc 3145801 ttacatttga taatccacaa tttcttgcag cagaaggtcc agagttttca attttcatga 3145861 ttttaatatt attaggatat agatttttaa aggattcaca aatttgagga ctgctgtcaa 3145921 cactaccatc atctattaat atcagttcta tattttcctt aaatccaatt gactggttaa 3145981 ggacactctc tattgaatat cttaaataat tttcagaatt atatattggt ataattatag 3146041 aaaacatgtt tgtacctctt tatttagaag ttaaaggatc gtttcaatta ctcttttaga 3146101 agccttgcct cttctaaatt acaaaattta ttataaaaat cctcatagtt atgatctata 3146161 taaggattat gtaacaactc ttttaccgta tctataagtt cttcacttgt ttgaagcaag 3146221 tttcctggcg ttttttgctg aaaattaaag taaaaacctc tgatacagtc tctataagcc 3146281 gggagatcat acacaaaaaa tacaaggttt ttttaaaaat tcatattatc aaaaaagaca 3146341 gaagaataat ccataatcaa taaatcacta attaaatata aatctcgaat atctttattt 3146401 aaagaaacat cgttcacaaa atatttatat ttccctaatt aaattgttct gaaactggat 3146461 aataccattc ttacaagaat aaccatagag tctccaaggt tccctcttca tttcctctaa 3146521 tcaaattaaa gttaaattta tactggccag ctttcttaaa attcattatc ccgcaaagtt 3146581 ggtgcatata aaattatttt tctttaattc cttatttgat aatgtagaat tggtagggga 3146641 ttgtagctaa actgtttcca gaatagcttt caaataaaat taatttattg tttcttggca 3146701 gaaggacaaa aattttaaac aaaactgaat aaactctaac tagtaaactt ctgcaattgg 3146761 ttataataaa aatttcatca gtgaactcct taaagagtga agattaatat ttacgcaaac 3146821 aagaaaaaaa gaagcaactg aatttacttc aagcctcttt tagttagtgc ttctataaac 3146881 tagccatatc ttttctgatt tgggtagttg aaatgcctgc tattcttgta aggtaaatgg 3146941 cctcatagta ttcctttgta gacaatcgta cgattaagta atcccaggtt cttttgctct 3147001 ttccagtagc ttcatatgtc catagtgaaa taaatcaaac attccgtacg tatcactttc 3147061 ttcattagat aacatcacct tccaaccttt tccaacttag aaaaaacaaa aatccttaac 3147121 tgattgttta tcatttcgac atatttttta cgttccatta ataataaaca ataatagcat 3147181 atgttcctat aaaagttaag gctctttaaa aatgtaaatc atcagcactt tttgacaata 3147241 tcgttgcatt gatgtgtatt ttttacagat ctgatatctt atctatactc attacaacaa 3147301 gttttctatt ccggaagagt caattctttt tgtcgcgttt tcaagtgtaa tgattttctt 3147361 tctgctgcgt catttatttt gtacgccctc ctcatattac ttcatcgtca aaacgtgaag 3147421 gaattgtaat acgtagttcc taaaaatttt cgtggtaaaa tttagtgaag tctttatcag 3147481 gctaagggac tttatctaaa ctacgaatta catatggaga tatatagatg aaaaggaggg 3147541 ttgatatgat ataaacgaaa atcaattaga taaaggaaaa actgaacact tctgaaaaaa 3147601 gtgataagtt tctttcacta tatcctccaa aaagaaccta aaggtcttgg acatgctgtc 3147661 tggttcgcgc ctaactttat cggcgatgag ccgtttgcgt ttctgcttgg agacgatatt 3147721 gttcaggctg acacaccagg gttgcgccaa ttaacggatg aatatgaaag aacactttct 3147781 tctattatcg gtgttcagca agtgcctgaa gatgaaacac actgttatgg catcatcgcc 3147841 ccgctgacaa gtgaaggccg ccgttatcag gtgaaaaact tcattgaaaa accgcctaaa 3147901 gacacagcac cttctaatct tgccatctta ggccgttacg tattcacgcc tgagattttc 3147961 atgtatttag aggagcagca ggttggcgcc ggcggagaaa ttcagcttac agacgccatt 3148021 caaaaactga atgaaattca aagagtgttt gcttacgatt ttgaaggcaa gcgttatgat 3148081 gttggtgaaa agctcggctt catcacaaca actcttgaat ttgcgatgca ggataaagag 3148141 cttcgcgatc agctcgttcc atttatggaa ggtttactaa acaaagaaga aatctaaaca 3148201 aaaaggctat tggacattca tccaatagcc tttttttatt tcaacatcaa agtcagtgta 3148261 tgctcttcat tatcaactgc aaaaacctga tcatctgtat tcacaagaaa acgcttcttg 3148321 ctgctgtcat acaatacatc gctatcactt aaggatagtg acgccgggtt gataggagaa 3148381 atgttatgaa aaataagctc tgttgcttta tcattctcca gtacataact gattttttca 3148441 taatcaaaat tcagcgtttt tctgccgtca gccttatttc cttcagtata accattcaat 3148501 ttcgattgaa tgctggtgct gctgtctcct aggaatttca gaaagtattc ataggaagat 3148561 gctgcgtttt gcgagacata agacgtaaat gcagtggcat gcaattcagc gtgtttcatg 3148621 ttagttgcaa cagcgctctg tttcacataa taagagtgcc cgtcaaactt tattttcgct 3148681 gcttgtttgc cttttgcagc taccgttact tttgtaccga atggcagtgt aacgtcagcc 3148741 ttctgtttca aaccctgatc cttataagca gccgcttttt catttgctat aaacccttgc 3148801 ttattgattg cagttaagcg ttcctctgac ttgccctttg catcgccatg atggttcttc 3148861 acttcatttt gcggaatagc gccaaacgaa gcaattgtac gaagcggggc attaaagaac 3148921 atcgttcccg ccatgaagac agtcagaata gacaaaatag caatttgaat ggcattggcc 3148981 agtgatttcg gctttttctt ctttttgcgg aaacgggcaa acgcttcagg atcttctttc 3149041 ttcctctctt ctgtctgctc ttttttatat gtctcttttt cttttttcga tagcttatta 3149101 aaccagtcaa taaacgcttt gtactctttc acaaccgttt ttgtttcatc aaacatacga 3149161 agctcgccat agtgcatcca agcaacacgg tcacacatct tttcaatctg accgattgag 3149221 tggctgacaa agaaaatcgt ttttccttgc tttttaaact catttattct gtctacacac 3149281 ttctgataaa acgtttggtc ccccacagaa agagcttcgt caataattaa aatgtcagga 3149341 tcaatatgca cggagatcgc gaaaccgaga cgcgacttca tcccgctgga atagttttta 3149401 accggctgat taataaaatc gccaatctcg gcaaattcaa cgatgctgtc atacatatca 3149461 tcaatttctt tattggttaa ccccatcatc aaacacttga gccggacatt gtcccggccc 3149521 gttaattggt tattcaaacc ggcagcaatc gcaatcagcg acggctggcc gttcatttca 3149581 atttcaccgc tggtcggcgg aataatttta gccagcaggt tagacatggt cgattttcct 3149641 gacccgttta ttcctacaaa gccgattgtc tccccttcat acacgtcaaa ggagacattc 3149701 cgcacagcaa aaaaaccatt atccttagcc ggaaaaaaca atcctttaat cttgtccgat 3149761 tgttttttat acaaatgata ctgctttgaa acatttcgaa acgaaacttt tagtttcatc 3149821 gtaaaatctc cttacgtatt aaagaaagtc aacaaacttg tctctgaatt tcatatgcag 3149881 gatagaacct actaacaata aaaggaatgt gaacaaccaa aagtacagcg tgtacttcat 3149941 gtcatggaaa aaccatgctc catctaagaa gctgttccgg aatccttcaa taatatagaa 3150001 tagtggattc aacttcagaa caggcactaa ttcggggtgg ctttgaccga gtttcgcatt 3150061 aacatcccaa aaaattggca acaagaaaaa caaaagtctt gttacggcct gcagcaaaaa 3150121 ttgataatct ctaatcagca cactgatcgt tgagttaaac aaactaaacg aaaacataaa 3150181 agcaatcata cagatgaagt aataaatata ttgtaaccaa tgcacactcg ggaacacacc 3150241 attaactagg agtacaatga tataaatcac catcatgatc atataactaa ataagttaga 3150301 tgcaattgcc acggacggta gagaactaat cgggaagttc attttagcca ccatattaat 3150361 gcgcttaaat acactatttg atccatcaag tatagttgga ctgatgaaaa accatgggat 3150421 taatcctgcc agcatccaaa taataaaagg cacttcgccc gctccggttg tcacaggacc 3150481 gccctttcta atccccatac caaatacgaa ccagtaggcc agcatttgga taagcggatt 3150541 taagaactgc cataagacac ctaaataatt catttgatat ttagacttgg tttcataagc 3150601 cgccaatctt aaaattaaag gaaatgacgt tatttgctct ctgagtatac gcaacaaatc 3150661 attcattttt tatcttcctt agacttaatt gtttttggga atctttctgt ttaaaatttg 3150721 aaagcaccgc tgattattgt aacagatcct gcattttttt tcacttctca acaagtatct 3150781 aaaaagctgc cgaaaaatcg acagctatac attttataaa ataacctaaa ttattcagct 3150841 ttaaatacag tattaacaac cttttcagat gaacgtcctg actctaaata gcaaaactta 3150901 tcatagaaag gaccaaaaga aaccggaagc ttataatcag gcgatgagat ctgcttgata 3150961 gcctcaatcg tttcttcagt agtttttacc aaaggaccag gagcttcttt ttcaaaatca 3151021 aagtagaaac cacgcaactt gtcccggtag gtttcgatgt cagggacaaa gaatagcatt 3151081 ggccgtttta aatttgcaaa atcaaagaat actgaagaat aatcagtaat cagcaaatca 3151141 gaaaccatat acaattctcg aatatcctca taagcagaaa aatcatatgc aaatccttca 3151201 aaaggaccta aatcaaaatt ctcagctacc agataatgca ttcttaagat tacaatatat 3151261 tcatttccaa gttcttgtct aagttgatgc aaatctaaat cgagatcgaa cttataacgc 3151321 ccttttgcat agaactgatc atctctccat gtaggggcat ataaaataac ctttttatca 3151381 cgaggaatat ttaacctact ctttatcaat gatattgttt cctcattatt atcattatga 3151441 agaaaatcat ttctaggata tccagattca atcattgtct tgttaaactg aaacgcccgt 3151501 gtaaagatct cagttgaata accatttggg gaaatcaagt aatcccaatt agaagcttcc 3151561 ttgataaaat tccttttata ttttttggtg tttgtaccag gcatatggac ttcttccata 3151621 tccattgcaa gtctttttaa aggtgtgcca tgccatgttt gtaaatatgt tgtatgacta 3151681 ggtttcggaa tccataatgg aagccggctg ttaacaaccc aatactcagc tcttgccata 3151741 gcgaagagcc attttaatga gaggcgatta atgtaaggaa ttcccttttc atcaaaaggc 3151801 gctgaatatt gtttatttac actccaatac attttatact cagggtggtt ttcccgcata 3151861 tattcgtaaa tcgctctcgg attacaactg tattgtttcc cattaaaact ttcaaaaatg 3151921 actgttttcc ttttaactgg cattctgcta gccatcatga atagagattt gtatgtttta 3151981 gtgattaact tgtttctcat ttttgtgatc ttttttattt ttgatactaa tctcttcttc 3152041 tttcctttaa taaagtattt catccttgtt ttcaggctat agtcgtttac tctgatacct 3152101 agagtctgct ttttcttttt cttaaagact tcataacgaa ctggtgcgtt gtttgtttta 3152161 ataatactta ctaatccttt taatttgttt tttcgatctc ctaaaacaag agcagtgctg 3152221 ttgaactgaa tatccgttcc ttcatcgtca ttgcatatat actccataaa aagacgataa 3152281 acataacgtt tttcatttga gaaaggaatt tctttcaaag gcactttcac ttcaaaatca 3152341 tacagttccg gaacaaaacc atctgctctc atgttttcca ggccatgtgt ttttctttct 3152401 agcttgattg gaaatttttc ctcaataggt gtttctccac ccttttttaa aataaggttc 3152461 aagtttttta tccgatattg attttcggaa ctcaggtacc ccgcataacc tgttatgctt 3152521 atttcttcag agctaatctc gatttgatca aatctgatga ttttggcctc tcttttcacc 3152581 ttaatagaaa agttgccttt atcagttgta taaggtaaaa tcaaaagttc tgtggtttga 3152641 tcgacatgaa aggcgcgctc aattgaattt acttcagcag aaagacgctt caagagtggt 3152701 tcctgctccg catcttcata tttttttcga aattcgacat aaaaatcata tgtttgtccc 3152761 atttcaacag gcataggcaa aacatgagca tttatctcag ttttatactc taatgagcca 3152821 gtgttttgaa gcggaaattc agattccgtt cctgaacgtc tctctttcag ctttaaaaat 3152881 aactggtaat cctctaaaaa ttggtgttct gaatcaattg agattaacaa ttcaagactt 3152941 cctaaattgt ttttcaagct tttcaaaata catttaatca cagtgttttc aatcattact 3153001 tttttctgct cctctgtata aaagctcttt cctttttgct tccttttatt agtgtcaact 3153061 actaaggaca ttaactctct tttatttccg tgaccctcca agagaaattg cctttaactg 3153121 ttgtataggg ctctactcta tagccattat tagtatctat actgtttcct gacaattttg 3153181 tttcttcact cgaaagtctt cgcattgttt taatatggcc atttgcattg aaaacaatat 3153241 aaaaatcaat aacttgggtt ttattagcag ctatcttttc aatatttaca tctttttcga 3153301 gatcaattac aaacagttga tcattttgta agtttgttga aataatttca gccttattct 3153361 ttctgtccaa gcccactaaa cgtatttttt taatatcatt atgatcaaaa ttctcaatgt 3153421 caatttctat tttagtttta tcaaaatcct cagtatagga actaatagaa ggatcttttt 3153481 ttccaacctt tttagagaac ttctctcttt ctattcgcac ctcaatcatc tgattaagag 3153541 caaaagccca attttcaata tagttgggtc ttgaatattt ttcagccatt ttaaaagctt 3153601 gttctgaaaa tttttgatga gtactttcat ctttcatcaa agagataata gcttgaccca 3153661 atttctctat attatactgt tcaatgacat atccatttgc tccgtcagta actaagctcc 3153721 ttgctccgta atcataatcg tatgttacaa ctggacatcc attgctcagt gcctccatat 3153781 ttgatagacc gaacccttca aaatgagagg ttgaaatggt tagccaagct ttttgaaact 3153841 ctgagtcagg gttatccgta tagcctttca aaaagacatt gttctgcagt ttggtatctt 3153901 caatttcttt ttttattttt tcgaaatctt cacccgatcc gaatatatca agttttgctt 3153961 caggaatttc tttcacgact aaactaaatg cttttactgc atgtatcaga tttttcatag 3154021 atgcaagtct tgaaataatg acagctttgt atttttcact cggcacattc aatacagcgg 3154081 gatcaagagg cttatcaatt gtatgcggag taaagaaaaa cgtctcttgt tcccctgaaa 3154141 tcaatttaaa atcttctagc tgctcctcag ttataaaaaa gacagcatcc aaattataca 3154201 tctgactaaa tacttcttta tagcgaccct taatttgata tttattgctg ccgtaatgct 3154261 tgttatgaat aattgctcca taataggaag aaggtgattt tttcacttta aagacatgtt 3154321 tgtcttgcgg tctgctgtcc actaaaaaca acttaggttt atcattttgt ttttgcagat 3154381 attctatcca atattgacgc agttccgatt catcttttac ttttatctca ccctcaaggg 3154441 agtaccaaat aatatgagat aattgaacat ctttttcttc attgttccat acatagagtt 3154501 tgtctaaata tacttgattt tggtcattaa tatattcctg cagatacatc ttgtttagct 3154561 gcacatcata atgagtaacg agaactaagt ttccgttctt cgtatattcc tctctcttta 3154621 tgagctggtt tttatcattc caatagtcga cgtaccggat agtttctcca tctccgtagt 3154681 aaactacaga catttcattg ttcttcttac caaacaatct caacagagtt tttgcaaatt 3154741 tccccattcc aacttgcttt tttatctggt caaggcctat cctttcttcg tatgatcttt 3154801 tcccatttgt tctaacactt aaaaaatcat cgaatagatt aataacactt gtgaattttt 3154861 tatcaatctt accgttgctg tacaattcat caatttttga agacaactct aaatcaaaac 3154921 gaaacgttaa gaaaaaggtg ttttggttac actcttctcc aaataatttt gaacgcaata 3154981 ataatgattt cgtcagaccg ccataattac ttggcagtcc accagagata aaataataat 3155041 ccatgtcagg aatttgtttt atattagatt cactcaccgc atgtaaagac aattttttac 3155101 tccctttcgg catctagaat atatgatcat tgaaatttat atctacccgg atactttagt 3155161 cacaaaaatc aatgtaagca tcaaaaagta cttcttattt caataagaag tactttaatt 3155221 agatattgaa ccaatgatat caggatccta aattataaac cagcaatttc ctctttgatc 3155281 tttgttgtag agatgccttc tgttcttggg aggtaaacaa cctcacactg atctttgaga 3155341 aagtcaaatt taccttccca gtcatccccc ataacaaaaa catcaatatt atgatcaata 3155401 atatcttgct ttttttgctc ccaattcttt tcaggaatta cttcgtccac atatcgaatg 3155461 gtttctaaaa ttaatttacg gtgctcatag ctgtgataag cttttttttg cttttgtaaa 3155521 ttgaattcat ccgttgaaat agcaacaact aaataatcac caagctgctt tgcacgctca 3155581 agcaatttaa tgtgacccca atgcagtaaa tcaaaagttc catatgtgat aacttttttc 3155641 atttaaagaa acgctccttc ctaatgttaa acactattaa aaacactact gacgttagcg 3155701 attaaattct aaaaacctgt ttgtattcct tatatcgaca tatttctcgt atgtcttcac 3155761 tgatcattaa ttatagcata ccgcctaaaa aaggttaagt actcatgagg agaaaaacat 3155821 tccaaaatat gtaattacac tcagactcca ttggcaccaa ggtctgttgt tcattcgttc 3155881 attcaattgt aaaattggaa acatatttaa atttaatgta aagataatgt taatcctttg 3155941 ttgaagattt atgttaaaat ataaggtagc ttgattttgc ttttagaaac tctcggtttt 3156001 taactatata aatagaatct taaaggaagg aggagccaga catgcaaaca gagactattc 3156061 acaatattcc ttatgttaac agtaacttaa catcatttat cgattaccta gagaaacatt 3156121 atattgatca aaagattggt gctgtcattt ccacagtcaa ccctgaaatt gcatttgcag 3156181 ctattaaaga tcgggactac tttgatgtac tatcttcttc aaacttcatt ttgcctgatg 3156241 ggatcggtgt agtcatgatg tcacgtttga ctaacaacag gcttcagtcc cgaatcgcag 3156301 gttacgatgt ttttaaagaa cttctgggcg ttgctaacaa aaagaaaaaa cgcatatttc 3156361 tgtacggtgc gaagaaagat gttataaaag gtgttgtatc caaaatttct tctgaatacc 3156421 caaacattaa aatcgcaggt tattcagacg gttatgttca agatcgcacc ctagtggcaa 3156481 aacaaattgc aagagcaaat cctgacatgg tattcgtagc tttagggtat cctcatcaag 3156541 agaaattcat tcataactac agacacttgt tccctaaagc cgtatctata ggtctaggag 3156601 gaagctttga tgtatttagc ggtaatgtca aacgggcccc ttcctggatg atacgtttaa 3156661 atttagaatg gttctaccgg ttaatcttga atccatggcg atggaaaaga atgcttagca 3156721 tcccaaaata tgctttaacg gttttaaaag aagaaaaaaa caaaaaaact ttctatccaa 3156781 agcctgaaaa agatcataca aaacagattt aaaaacaaaa ctttcaaata aatggatgat 3156841 aaaaatgaaa ataagatcac tactggcgaa ttgctatttg tattttttat cagcaatcgc 3156901 cttttttctg caatgggtga aacctgaaag caaagtgacc ctcctgatct cattcgaagc 3156961 aaacgcaaaa gcgattcttg aggaatatga acaaggacaa tactcttata aacttaacat 3157021 cctgtatacc cagcaggcct ctgctattgc cgagagcttc ccgaatgtag atgcatattt 3157081 attacaagaa aaaaacccta tccatctcat taaagctgta tacctaatgt ttaacagtaa 3157141 agtgatcata acagataatt actttctatt aacaagtgtg ttaaataagc ggaagcaaac 3157201 gaaatgtatc caagtatggc acgcaaatgg ctcactcaaa aaatttggtt tggaagacat 3157261 tacaaacatg caacggacga aaactgatat taaaaggttc caaaaagtat acagttcgta 3157321 tgattattta actgttggct cagaagagat ggcaaatatc ttcaagaaat catttggaat 3157381 aaaggataac caattattaa aaataggtgt acctttaaca gacccttatt accgagaaaa 3157441 caagaaaaaa atttcagata ctctaaacat acaaagaaaa aaaataatcc tctatgcacc 3157501 gacgtttaga gattataata tgcaatcaat tcaattgcct tttacagaag aacaattaat 3157561 tcatcagtta aaagaagaat atgttttatt tgttaagctg catcccgcca ttcagaacaa 3157621 tattgatatt aaatattcca gtgattatat taaagatgtt tctaactatg ccttgtttga 3157681 tctactcatg gctgcagaca tattaatcac tgactattct tctgttccct ttgaattttc 3157741 gattttaaat aaacccattc ttttttatac ttacgattta aaactttatc aacagaagcg 3157801 gggattggtt gataattatc tttccataat acctggaaga gcctgctatg acagtgaatc 3157861 attaataaat gaaattcaaa ccccatttaa ttattccaaa ataaaagttt tttccgatag 3157921 atggaataag tattctgatg ggaattcaag ccaaaattta ttgaatttca tcgaaaattt 3157981 aataagctaa atgatgacac ttgttcaaaa cagaacaagt gttctttttt ctattgaata 3158041 ccgaacgtat gtttgcttta atgtaattag ttgcttatgg cagcaaataa taatagaggt 3158101 ggtaaattta tgagaaaaaa agaactgttt gatttcacca acatcacgcc aaaattattt 3158161 actgaactac gtgtagcaga caaaaccgta cttcaatcat tcaatttcga tgagaaaaac 3158221 caccaaattt atacaaccca agtcgcaagt ggattaggaa aagacaacac ccaaagctat 3158281 cgcataactc gtctatctct tgaaggttta caattagaca gcatgctgtt gaaacatgga 3158341 ggtcatggta caaatattgg aattgaaaac cgtaatggca ccatttatat ttggtctcta 3158401 tacgataaac caaacgaaac agataaaagt gaattagttt gtttcccata taaagcaggc 3158461 gcgactttag atgaaaattc taaagaactt cagcgattct cgaatatgcc tttcgatcat 3158521 agggttacac ctgctcttga tatgaagaat agacagttgg caattagaca atacgataca 3158581 aaaaataata ataataaaca gtgggtgaca atctttaacc tggacgatgc aatagcaaat 3158641 aaaaacaatc ctctttatac tattaacatt cctgacgaac ttcattattt acaaggtttc 3158701 tttttagatg acggttattt atattggtat acaggagata caaacagcaa aagctatccg 3158761 aatctcataa ctgtatttga ttccgataat aaaatagtgc tgcaaaaaga aattactgtt 3158821 ggcaaagact tgtccaccag atatgagaat aacttccgtg aaccggaagg gatctgtatg 3158881 tacaccaatc ctgaaactgg ggcaaaatca ttaatggtgg gaattacaag tggaaaagaa 3158941 ggaaatcgta taagcagaat ttatgcatac cattcttatg aaaacttcat gaatcatgta 3159001 cctatgcttc gatccccttt attaaaaacc gtggggcacc aagatacacc tccagaaaga 3159061 tttcaaccat ttattcaaac cttcatttta gagtataatg ctcaaaacaa aaaatggatg 3159121 gttccgactt caggttattt accatcttac acatcaaatt tagtccgaaa tattactatc 3159181 aatgcagatg gaaacttgca agtcacatta aatgaacgct atattagttt actgcatcaa 3159241 tcgatagaag gagatttccg cttaaaacaa aaggatatcc gaatgggatc ctggtatttt 3159301 gccggcggag aaaaatcaaa tgtgcttgaa ataggtttta tgaaagggag tacaaaaatc 3159361 agacccgatg atgcagccat ctcaaatgct tcaagaatga gtatttttat gattgttgcg 3159421 gacaagattg aggtgtgata atcaaatagg ctgtagctat ttaatagcta cagcctattt 3159481 gcaactttct aagtttttta tcgatattcc ggaacatcgg cctactttat agaccagctt 3159541 ctttcggggc aatatgcata aagaaaagac tccagagatt ggagtctttt tcttttattg 3159601 cacccgtata cttcctgcgt atttatcctt ccaatatgtg ctcgtgttca tattggtaat 3159661 ggtcacgccg tttgataatg tgacatgaac aacttgtccg tttccgatat agatggaggg 3159721 atttaagctt gttgattgaa agaacacaat gtctcccggc ttcaggtccg ccttctcaat 3159781 cttagttccg gcattgtact ggcttgttgc gtatcgaggc agggaaatac cggctgcttt 3159841 ctggtataca tattggacaa atccagctgt atcaaatccc gtctcaggtg ttactccgcc 3159901 ctgtttgtaa ggcacttctc cgacataaag cgtcgcttcg gaaacaatcg gattttcttt 3159961 cgggattgtc aggttgtcaa atcggcgaat acccgtcatc ttcgatttcc agtaatcctc 3160021 tgacaaatag gaaatggtta ctttttctga ccggcttgcc tgaatgaacc tgcctgcgcc 3160081 cgcataaatg cctgcatgtg aaattcccgt tttatacgta ttgctgaaat agacgacatc 3160141 accaggcttt atgttctgag gggctacctt ctcgcccact gcccactgct gttcggctga 3160201 tcgcggtaga taaatgccga gtgcctgttg aaacacatat tgcacaagcc ccgagcaatc 3160261 aaagccctct gacggcgtgc ttccgccaaa cacatatggg acaccgatat atttttcggc 3160321 ctcctgaacg acaggaacat cagccgttgc cggatcggca gcgattcgtc tcgccccgat 3160381 ataagttccg ctccaatagc tgcttttttt gtaattggtg atgataaccc cttttgactg 3160441 tgtactgtga accatttggc cgtctccgat ataaagggcg tcatgtgtcg gaacagtgcc 3160501 ggtgcttccc tctttcttga aaaacaaaat atcacccggc ttcaggtttt ccggttttac 3160561 agctgttccg attttatact ggtcgtttac agatctcggc agatgaatat cagccttact 3160621 gaacacatat tgtatcaatc ctgatggatc gaaaccctct ttcggcgttt ccccgccata 3160681 tttatactga tatccaagca ggttttttgc ttcgctgaca atcaattctg atgatgtatc 3160741 agcttccgca atctccgctt ttgtcataat tggaaccaaa aaacaaatga taaccgccac 3160801 aagcaaaaac ttcttccagt ttgccagtgt gttcactttt attatctcct cctctttttg 3160861 cagttttaac atcggtattt ttttgaatat gttaagagac tttttaatat ttttacagaa 3160921 tgaatatgct gggcaaataa aaagagagtg tctcatcaga cactctcttt tttgaattat 3160981 ttattggcgt ttaccggttc ttcctgctgc tggattttat tcatttccat atcaatcttc 3161041 tgtttttcct gatctgtcag ctgatcattg aatttaaaag ctgacataaa catgaacacg 3161101 atggctacgg caacaaacgg ccagatggct ttgacaaatt tcatctttat cactccgatt 3161161 atttagattt tagtttgtca ctatgatcaa tatcaaacgt cagttttccg tcttctactt 3161221 tccaagcgaa attagagtct ttcgtcagtt cgcgaataat ggttttctgt ttaaggctgt 3161281 cttttttcac aggcgcaggt gtcgcttcat ggatatcgat cggtgtcact tcaaagcgtc 3161341 ctgttccatt tttcttcagg tgatactgaa ccagtgcact gtctcttgtt ctcgtccagc 3161401 cttggtcaaa gacaaagttg ccgaggctgt agaaaatgac ggttccgtta tatacttcaa 3161461 tcggttctaa gacgtgcggg tgatggccga cgatgatgtc agctcccgca tcagacatgg 3161521 ctcttgcaag ctggcgctgg cggtcatttg gatcattgtc atactcttgt ccccagtgtg 3161581 actgcacaac aacaatgtcc gcatgttttt tcgcttctga aatcataggg atgaagattt 3161641 caggatctgc gggcagcacg cccggcgtat tctttttagc cgcgaaacct ttcccggaca 3161701 catcggtaaa gccaagcgtc gcaatcgtta ccccgttgac tttctggtac gaaattttct 3161761 ttttcgcatc acttaagctg tatcccgctc caacgatatc aagattttgc ttcgcaaatt 3161821 ctccaagcgt atctttcatg ccctgaacgc cgtaatccat tgcgtggttg ttggcgctgt 3161881 tgagaaccgt gaaattcata tccttcaaga ctttcactga ttccttattc gtctgcagat 3161941 gaatctcttt atctgcttgt ttataattct tttgataggt taccgggttt tcaaagtttc 3162001 ctgctacata atccgaggct ctaaagatcg gttcaacata ttgaaaaata ctgtctgccc 3162061 ctttttgctc cgttactttt tcaacatagc gtcccatcat aatatcgcct acaaatgagg 3162121 ctgagagtac gtcgtcagaa tacgttttga ccttcggcgt ttccgctttt cccgcccaca 3162181 tgaaagcgaa cataaggaca aaaacgatcg gaatggcaat aaatacgtgc ttattggttt 3162241 tctttttttg ctgttttgtc agctttagca gcttttcatg aaagctcagt tcttttttca 3162301 tcgtttgaca caccttacat taaattaagt agtaaacaaa catgatagca aaggtcgctc 3162361 cgctcaatag cagcgtgctt ccgaacgtaa tggttaaacc ttgtttctga atggtattgg 3162421 caattaaacc tggcacgatg atgccgattc ctcgaaattc tgcgatttca aatggtacaa 3162481 tcgggtatag aaaatcaaac gcgattttta ggacgatccc tgttatcagc atggcagcga 3162541 attttctgcg tccgtacaaa atcataaatt tggataaacc gtatttcaca atgacatacg 3162601 tgagcaagct cactagcaaa acaagtaaaa taaagaccgg ctgattaaac acaagtccta 3162661 aatatcccgg tacaacaagt cctgccggca cgatccctgt tttttccgca aaaattaaac 3162721 tgagtagtac acctaaaatt agtgcgatgt ataaatctga tccgaacatg tctgcatttc 3162781 cccctagctt acgagctgct ttaccttgta ttcgtggatt ttttcaatta aaggctctgc 3162841 ggcaccatga atattgccga cgccatatat gacacggttg tgcattcttt tctttaacaa 3162901 ttccataatt tcatctgttg acttatactc tagatcatgc agtttgtctg caggaatttt 3162961 gccttcttcg taggctttta cgatcggttc tgttgtttca ccgattaaga tcagttcact 3163021 tgcttcaata taaggcaata cgtcatttgc gaattgctgt gtccgatcga cacggtctgc 3163081 gcggcagttc atgatgatga tcggatcatc ggtcgggtaa ccgatttctt ttacacgttt 3163141 ccatatattc aaagtagaag aagcgtcgtt tgcggcaaac ccattaacaa agtgcccagg 3163201 ctcgctcgga ctgatcagcg gaagaattct cattgctccc ggatctggcg gcgcattcag 3163261 cattccctta aatgctgttt cttcgtcaat gccgagtgct tgagccacac ccagcgccag 3163321 agaagcgtta tcagggaata ccatgtattc aaatttacgt aaatactcat ctgtaatttt 3163381 tgagttatca gcaatgatga cttttgtgtt tcgttctttt gctttttgtt taaagaactc 3163441 ggtatattca ctatctgtaa tgacaagatg gccattataa ggaattgtag cagtaaacgc 3163501 ttctgcaatt tcatcaagcg tcggccccat gacatccata tggtcttcca aaacattcac 3163561 aatgacgccg atattggcct gcagaagttc ttcctgaaag atgatttgat aatctgggtt 3163621 aacagccatg cattcactga caatcgcgtt agcccctctt tctactgttt ctctcatgac 3163681 ttctttttgc tctccgatat tcggcccctg aggtttccgt ttaatcggct tttcctccgg 3163741 tgtgtcccag taaatcattc ttgcatctgt tcctgttgtt tttccaacag tcttgtaacc 3163801 ggcttctatt aatattccgg ttgtcagcct tgtcacagtc gattttccgc ggatgccgtt 3163861 aatattcacc cgaacaggga gggcatcaat gtttttctga tgtcgtcgtt tttctaatat 3163921 tccgatgacc agtatgacag cacaggctat aatgagtaac cacattgctt ttcgacatct 3163981 ccttctatat tgttgtaaat tcattcatca gtatatagaa tcactatgaa ttctcaatcg 3164041 gcattatgta acataatctt ccctaatcga ctaagccaaa cttctctttt gaaagagatt 3164101 ttatacctac aaactgtttt ctatttttgg aaaacagcag gacttatacc ttatcacttt 3164161 ttaaaaaaat caaagagaat gcgctttcat ttttctcctg atatccttct ggacgtatag 3164221 tcacaccctg ctgtttgtat ttaatatgca tttcaaatca atcttttttt cagcctttgt 3164281 tatcaagcat ttcctgctat catgcgtgtt tccggttctt atgaacacaa aataatttta 3164341 tcctgtttct taaggacaag gtcataatgt catcctttct gcatggaata agcaatatga 3164401 ggcccattcc aaaatgacta aggaggttcg agatgaaaac gctaaacata cgagtccgaa 3164461 ttctctaaca taattaaaca ttttctggga tgatagtctt ttctgtttct ccccatttac 3164521 aggtctaaac gcatgacttt gaaacaattt taataaaact taatatttgt tcaagaaatc 3164581 ttcatccata tttgtgaaga ctttgtcaaa aaaagagtga aaaccttaaa tttttcaatt 3164641 atatatacaa tttacaatta gatttctttt gatattttta ttgctaactt cggattgttc 3164701 atgataatct atctatgtaa acggttacat aaacaaggag gagctgtttt ggctacaatt 3164761 aaagatgtcg ccggagcggc gggcgtttca gttgcgacgg tttcccgcaa cctgaatgat 3164821 aacggctatg tacacgaaga aacgcgaacg cgtgtcatag cggcgatggc gaagctgaac 3164881 tattacccga atgaagtcgc cagatctcta tataaaagag aatcccgact gatcggactt 3164941 ttgctcccgg atatcacaaa ccctttcttc ccccagcttg cccgcggtgc ggaggatgaa 3165001 ttgaaccggg aaggctatcg ccttattttc ggcaacagtg acgaggaatt gaaaaaagaa 3165061 cttgaatacc ttcaaacctt taagcaaaat catgtcgcag gcattattgc cgcaacgaat 3165121 tacccggatc tcgaggaata cagcggcatg aattatccag ttgtttttct ggacagaacg 3165181 cttgaagggg ctccttctgt gtccagtgac ggctatacag gagtaaagtt agccgcccag 3165241 gctatcattc acggaaaaag ccagcgcatt acgctcttga gaggacccgc tcacctgccg 3165301 accgctcaag accgatttaa cggcgctttg gaaatcttaa agcaggctga agttgatttt 3165361 caggtcattg agacagcttc attttcaatt aaagatgcac aatcgatggc gaaggagctg 3165421 tttgcctctt atccagcgac agatggtgtg atcgcgagta atgatattca agccgctgcc 3165481 gttttacatg aagcattgcg gcgcggaaaa aacgtgccgg aggacattca aattatcggc 3165541 tatgatgaca ttccgcaaag cggacttctg ttcccgccac tttctacaat taaacagccc 3165601 gcatatgata tggggaaaga agctgccaaa ctgcttttgg gtatcattaa aaaacagccg 3165661 ctggcagaaa cggcaattca aatgcctgtc acctatatag gaagaaagac gacaagaaag 3165721 gaagattaag atgcgtaata tttgtgtgat tggtagctgt tctatggatt tagtggtcac 3165781 ctcggacaaa cgcccaaaag ccggtgaaac ggttcttggc acgtcatttc agactgtgcc 3165841 gggcggcaaa ggagcaaatc aggccgttgc cgcagccaga cttggggcgc aagtgtttat 3165901 ggtcggcaaa gttggagacg atcattatgg aacagctatt ttgaataatc tcaaagctaa 3165961 cggcgttcgc actgattata tggaaccggt tacacatacg gaaagcggaa ccgctcatat 3166021 tgtgcttgct gaaggcgaca acagcattgt cgttgtcaaa ggcgcgaacg atgacatcac 3166081 cccagcgtat gcgttaaacg cgctcgaaca gattgaaaag gtcgatatgg tgctgattca 3166141 gcaggaaatc ccagaagaaa cggttgatga ggtgtgcaaa tactgccatt ctcacgatat 3166201 cccgatcata ctaaacccag caccggcccg cccgctcaag caggaaacaa ttgatcacgc 3166261 tacctatctg acgccgaatg aacacgaggc ttcgatttta ttccctgagc ttaccatttc 3166321 cgaagctctg gcgctttatc cggcaaagct ctttattacg gaaggaaaac aaggcgtccg 3166381 ctattcggct ggcagcaaag aggtgctcat cccgtccttc cctgtagaac ccgttgatac 3166441 aaccggagcc ggtgatacgt ttaacgcagc atttgccgtg gccctggctg agggaaaaga 3166501 cattgaagcc gcattgcggt ttgccaatcg tgccgcttcc ctttctgtct gctccttcgg 3166561 tgcccaaggc ggaatgccga caagaaatga agtagaggag ctgctgtcat gaaaaaacac 3166621 ggtatactga acagccatct tgccaagatt ttagccgacc ttggccacac tgataaaatt 3166681 gtcatcgcgg atgccggact gccggttcct gacggcgttt tgaaaattga tctttcactg 3166741 aagccgggcc ttccggcttt ccaagataca gcggcagtac tggctgagga aatggcggtc 3166801 gaaaaagtca ttgctgcagc tgaaataaaa gcatccaatc aggagaatgc gaaatttcta 3166861 gaaaatcttt tctctgaaca agagattgaa tacctttctc acgaggagtt taagctgctg 3166921 acaaaagatg caaaggcagt cataagaaca ggagaattca caccatatgc caactgcatc 3166981 ctgcaggcag gtgtactttt ctagaaagga agatgaaaca tgcagattga aatgaaagac 3167041 attcataaaa cattcggaaa aaatcaggtg ctgtcaggcg tttcctttca gctcatgcct 3167101 ggcgaggttc acgcattaat gggagaaaac ggcgccggca agtccacgct tatgaacatt 3167161 ttgacaggcc tgcacaaagc agataaaggt caaatcagca taaacggaaa cgaaacgtat 3167221 ttttccaatc cgaaagaagc ggaacagcat ggaatagcct ttatccatca ggaattgaat 3167281 atctggccgg aaatgaccgt tcttgagaat ctatttatcg gtaaagagat atcctccaag 3167341 ctgggcgttt tacaaacaag aaaaatgaaa gcgctagcaa aagagcaatt tgacaaactt 3167401 tccgtctctc tttctcttga tcaagaagcc ggcgaatgtt ccgtcggaca gcagcaaatg 3167461 atcgaaattg caaaagcgct tatgacaaat gccgaggtaa tcattatgga tgaaccgacc 3167521 gcagcgttga ctgaacgtga aatcagcaag ctctttgagg tcattacagc gttaaaaaag 3167581 aacggcgtct ccattgtcta tatttcgcat cgcatggaag aaatttttgc gatttgcgac 3167641 agaattacca tcatgcgtga cggaaaaacg gtagatacaa caaacatctc agaaactgat 3167701 tttgatgaag tcgtcaaaaa aatggtcgga cgggagctga ctgaacgata tccaaaacgc 3167761 actccttctc tcggtgacaa agtattcgag gtgaaaaatg cttccgtaaa agggagtttt 3167821 gaggacgtca gcttttatgt gcgttccggt gagatcgtcg gtgtttcagg attaatggga 3167881 gccggccgga cagaaatgat gagagcgctg ttcggcgttg acaggctgga cacgggtgag 3167941 atatggatcg ctgggaaaaa aacggctatt aagaacccgc aggaagccgt gaaaaaaggt 3168001 ctcggcttta ttacagagaa tcgcaaggat gaagggctcc tgctcgacac ctcgatccgc 3168061 gaaaatattg ccctgcccaa tctgtccagc ttctcaccaa agggtctcat tgatcataag 3168121 cgggaggctg aatttgtcga tctgttaatc aagcgcctca ctatcaaaac agcatcaccg 3168181 gaaacgcacg cacgccattt atcaggagga aaccagcaaa aagtggtgat agccaagtgg 3168241 atcggcatcg gaccgaaagt gcttatcttg gatgagccaa ccagaggtgt ggatgttggc 3168301 gccaaacgag agatttatac gctgatgaat gagctgaccg aacgcggtgt cgctatcatc 3168361 atggtgtcat cagagcttcc tgaaattctg ggaatgagcg atcggattat cgttgtccat 3168421 gaaggcagaa tcagcggcga aatccatgcg cgagaagcaa cacaagaacg aattatgaca 3168481 cttgccacgg gagggcggta atatgaaaac ggaacaactg caaacagaac aaaaacggat 3168541 tcacttcgac ggagtcatgc aaaaactcgg cccgtttctt ggtttattta ttctcgttat 3168601 cattgtatct attttaaatc ccagctttct tgaaccgctg aatattttaa acctgcttcg 3168661 ccaggtcgcc attaacggat taatcgcgtt cgggatgacc tttgttattt tgacaggcgg 3168721 cattgatctt tctgttggcg ctattcttgc cctgtccagt gctttagttg cggggatgat 3168781 tgtgtccggt gtcgatccgg ttctcgcgat catccttggc tgtatcattg gtgccgtact 3168841 aggcatgatc aacggattat tgattactaa aggaaaaatg gcgcccttta tcgccacgct 3168901 tgcgaccatg actgtgtttc gcggactgac gctagtgtat acagatggaa atccgattac 3168961 cggacttggc acaaactacg gttttcagat gttcggacgc ggttactttt taggcattcc 3169021 tgtaccggca attacgatgg ttcttgcctt tgtcatcctt tgggtgcttc ttcataaaac 3169081 accattcgga cgccgaacgt acgctatcgg cggcaacgaa aaagccgcgc tcatttcagg 3169141 catcaaagtg acgcgcgtga aagtgatgat ctattcttta gccgggcttt tatccgctct 3169201 tgcaggtgcc atattgactt cccgcctgca ttcggcccag ccgactgcgg gagaatcgta 3169261 cgaacttgat gctatcgcgg cagtcgtctt aggagggaca agtctttccg gcggccgagg 3169321 acgcattgtc ggcacgttaa tcggggtgct gatcatcggc acacttaata acggacttaa 3169381 tctgcttggc gtctcatcat tttatcagct ggttgtcaaa gggattgtta tcttaattgc 3169441 ggtattgtta gaccgcaaga agtcagctta ggagggtttt acatgaaaaa ggctgtatcc 3169501 gtcattttaa cgttatcatt atttttgtta accgcctgtt cgcttgagcc tccccaatgg 3169561 gcaaagccat caaactcggg gaacaaaaag gaattcacca ttggcttgtc cgtctcaacg 3169621 cttaataatc ctttttttgt ctcattaaaa aagggtatcg aaaaagaagc taaaaaacgg 3169681 ggaatgaaag tcatcattgt tgatgcacaa aatgattcat cgaaacagac gagtgacgtg 3169741 gaagatttaa ttcagcaagg tgttgatgca ttattaatca acccgactga ttcttcggcg 3169801 atctcaacgg cagtagaatc tgcaaacgca gtcggtgtgc ccgtcgtaac aatcgatcga 3169861 tctgcggaac aaggaaaagt tgaaaccctc gttgcttccg ataatgtaaa aggcggtgaa 3169921 atggccgcgg cgtttattgc cgacaaactt ggaaaaggag caaaggtggc agagcttgaa 3169981 ggcgtccccg gcgcatctgc cacacgggaa cgcggctcag gattccataa catcgcagac 3170041 caaaagctcc aagttgtcac aaaacaatca gctgactttg accgcacgaa aggcctgact 3170101 gtcatggaaa acctgctgca gggacatcct gatatccaag ctgtttttgc tcacaacgat 3170161 gaaatggcgc tcggtgctct cgaggcaatt aacagctcgg ggaaagacat attggtgatc 3170221 ggttttgacg gcaataaaga tgcgctcgct tccattaaag acagaaagct gtcagccacc 3170281 gtcgctcagc agcctgaatt aatcggtaaa ttggctacag aagcagcaga tgatattttg 3170341 cacgggaaaa aagtgcaaaa aacaatatcc gcgcctctca aactagaaac acaaaaataa 3170401 ttgtctgatg tttaggaacc tgcgataacg tgaatagaga tatagaatga attatttctc 3170461 ttacgtgagg agaggaacgg catgaacaaa ccaacaaaac tattttcaac attagcactt 3170521 gcggctggaa tgactgcggc ggctgctggc ggcgctggca cgatccatgc tcaacagcca 3170581 gaaacaacgg taagcattga tgatttatac agttatccga ttgattctta tttggtatca 3170641 gcagaggctc taaatgtcag aacgaagcct tccgcatcaa gccagaaagc cgatacgctg 3170701 cacttaggag atagcctaaa gctgatttcc ttctcaaatg ctgactgggc aaaggttaag 3170761 tataaaaatg gaaaaacagg atttgtatcc actcattaca ttgttaaagc agcgacaacg 3170821 gtaaaaacca aaacaaaaac aaaagtgtat acatccgctg acggaaagag cattaagact 3170881 cttccagcag acacaagcgt ttctttttta ggctggagta aaacgaataa aggcggtttt 3170941 gattttgatt gggtattcgt tgattacggc ggtacgacag gttatatgaa aacaaaggat 3171001 ttacacatga caaaataact gagagggatt ccgcataaat gcggaatccc ttttattatg 3171061 aattgatttg tcacattccc aagatatttc tcaggaaata ttgtcgtatg ctgtgtcgaa 3171121 accttacatg atcatcgaca tttttgttca cgctaaaaag cggaggtgta aatatggatc 3171181 aatttgaagc agcatatgaa tcgtataaag cccggcaaac aactgccgat caagaaaatg 3171241 ttccatctgg aaaagaagaa attattgcgg ttagaagaaa tgaggaagac aatattatcg 3171301 cagtgaaaac caatacagga agagagctcg actaccctac tgcgctgtca gaagcaaaat 3171361 caggaaaact cgctcatgtt gatgtcttcc ataaatacgg gcgtgacatt ttgcgaagtg 3171421 aaccggacgg catcaaggaa aataacctgt ctgagctgcc ggatttttaa acaaatacag 3171481 ccctgccgta tgttggacag ggctgtattt taaacaaaag gctgctggat gtattcggct 3171541 aaccgttttg cactgtgaga aatatcctct gcagctgcat aattcacgcc atagaacaca 3171601 tatggaggca gatacttcat gccgatcaga ttactcgtgg cctgaaatgg tttcaatagc 3171661 tcactgatcg agtaatgatt tgctccgccc gcttgatatt tttccgcttc gctccctgtt 3171721 gatacagcca gcatcagctc cttgccatgc aaggcatttc cttctgaacc aaaagcccag 3171781 ccataagtca gcacaagatc ctgccatttt ttcaagagcg gcggagagct gtaccaatat 3171841 agcgggaatt gaaagacaat ccgatcgtat tcctcgcaca gctgctgttc cttcgcaaca 3171901 tctatcgctt catccgggta ttccttataa agatcccgta ctgtgatatt gtcatgttta 3171961 ctcaattcct cagcccacgc cttattaaca actgaggtct ccatatgagg atgcactgcc 3172021 aaaaccaata ttttcatcag accacacctt tactgttttg atgttatttt atctaaaatc 3172081 aggaaaagag ccaaataaaa agaaagccct gctaaaaggg gctttctttt tttcttttat 3172141 tcagggcttc cttcagttgt ttcgatatct ttcgcaaaat cagggttatc cagattcgca 3172201 ttaaagaaat ccgctgtgtt cggaagtctg agattcatgt tcattttttg agaaatcgta 3172261 accgtgcaat cctcaagcac atagtcaaaa acgtgtccgc ctgaattgcg tccttcgtca 3172321 atgaagtgca ggtgatagcc agaaacggcg attccgtttg cataagctgg tgtcaagaaa 3172381 cctacaatcg ttcctctcac gttgtcgaag ttgaaaatcg gctgtgtttt gaccgcttca 3172441 accattggca cgtaaggttt ttcttgaagt tctactgttc ttgtctgcac ctttttaaac 3172501 aatccgtcaa tgcgaattgc ataaaataag tttctgcttg gcagcatgct gttgatctct 3172561 ttttcaaagt cttcgcgtgt cattttcgca tcaattttgt gcgtcatgtc cggtgtaaag 3172621 aacgtaaatg aacagaacgg tgaacggtct ccattttgga ccggtgtcgc ggttccgtct 3172681 gagcgaagac ggtaaaattc gccgtcaaac ccaatcagct ctccgtcaag cttgttaaag 3172741 gttccgatac cgaagtctcc atatttcgga atctctgaca gttcaaaatc tccgtcatat 3172801 actccgtcta atagagaagt cattgttgat acttgataaa tctggctcac aggctgatct 3172861 ttttgaccac ggctgagcac ttgaatgttg ctttctcgtt tcatatttcc cttcactcct 3172921 tttatttagt gctgttcata aaacagtgtc gtgatgcgca gagtgctaga gagctttcgt 3172981 tttcatgagt tccccgaatt ctttcggaag cttgtcactt gctaaattaa tgttatcact 3173041 gtagtcaacc gggacatcga tgatgacagg accttcagcg ttcatgcctt gacgcagaac 3173101 atctgccagc tggtctggtg attctacgcg caagccagtt gctccgaagc tttccgcata 3173161 tttcacgata tcgatatttc cgaaatcgac cgcagatgta cggttatatt ttttcaattg 3173221 ctggaatgca accatgtcat atgtgctgtc gttccataca atgtgtacaa ttggtgcttt 3173281 tagtcgaact gctgtctcta attccattgc tgagaataag aaaccgccgt caccagagac 3173341 agaaaccact ttttctcccg gtttcaccaa tgaagcgccg attgcccaag gaagcgcaac 3173401 gccgagtgtt tgcataccgt tactgatcat taatgttaac ggctcgtagc tgcggaaata 3173461 acgtgacatc caaatggcgt gcgaaccgat atcgcaagtt actgtaacat gatcatcgac 3173521 tgcattacgc aactctttaa cgatttcaag agggtgcgct ctgtctgatt tccaatctgc 3173581 aggcacctgc tcaccttcat gcatatattg ttttaaatca gaaaggattt tctgctcacg 3173641 ctctgcaaat tccactttca cagcatcgtg ttcgatatga ttgatcgtgg acggaatgtc 3173701 accgatcaat tcaagatcag gctggtaagc atgatcaatg tcagcgataa tctcgtctaa 3173761 atggataatt gtccggtctc cattgatatt ccagaatttc ggatcatatt caatcgggtc 3173821 atagccgatc gtcagaacaa catctgcctg ctctagcagt aaatcgccag gctggttgcg 3173881 gaacaaaccg atacggccaa aatattgatc ctctaaatct ctagaaaggg taccggcagc 3173941 ttgatatgtt tcaacaaatg gaagctgaac ctttttcaaa agcttgcgaa ccgctttaat 3174001 tgcttccggt cttccgcctt tcatgccgac caaaacgaca ggaagttttg ctgtttggat 3174061 ttttgctatg gccgcactga ttgcatcatc tgctgcagga ccgagttttg gcgctgcaac 3174121 agcacgcacg tttttcgtat ttgtgacttc attcacaaca tcttgcggaa agctcacaaa 3174181 agcggcccca gcctgccctg ctgacgctat cctaaatgca tttgtaacag cttccggtat 3174241 attttttaca tcttgaactt ctacactgta ttttgtaatc ggctggaata gcgccgcatt 3174301 atccaaagat tgatgtgtcc gttttaaacg atctgcacgg atcacgtttc cagcaagcgc 3174361 aacgacaggg tctccttcag tgttcgctgt cagcaggcct gttgccaagt tagaggcacc 3174421 cggtcctgat gtgactaaca cgactcccgg ttttccagtt aaacggccga ctgcttgggc 3174481 catgaatgct gcgttttgtt cgtgccgggc aacgataatt tcaggtcctt tatcttgtaa 3174541 agcgtcaaat accgcatcaa tttttgcacc tggaatgcca aatacatgtg tgacaccttg 3174601 ctccactaag caatcaacaa caagctccgc ccctctgttt ttcacaaggg atttttgttc 3174661 ttttgttgct tttgtcaaca ccctcactcc ttattatgca ttttaaacgt aaaattttaa 3174721 atatcttgtg ataagtttca ctatacactc tttggaaatt gacctccaat atcgattcgc 3174781 cttatgatta atatgtaata cgaattatta acctatggaa aggaatgcat attgaatgga 3174841 gcttcgccat cttcaatact ttatcgcagt agccgaagag cttcatttcg gaaaggctgc 3174901 ccggcggctg aacatgacgc agcctcctct cagccagcag atcaaacagc tggaggaaga 3174961 agtcggagtt acgcttctga aaaggacaaa acgatttgtc gagcttaccg cagcaggaga 3175021 aatcttttta aatcattgcc gcatggcatt gatgcaaatc ggacaaggaa ttgaactggc 3175081 acagcggacg gcccgcggcg agcaaggcct tctcgtaatc ggttttgtcg gatcagctac 3175141 atatgaattt ctgccgccga ttgtccggga atatcgtaaa aaattcccat ctgtgaaaat 3175201 agaactgcgt gaaatatcct cgtctaggca gcaggaggag ctactaaagg gcaacattga 3175261 tattggtata cttcatcctc ccttacagca tacagcttta catatcgaaa ccgcccaaag 3175321 cagcccttgt gttttagctt tgcctaagca acacccattg acttctaagg aatcaattac 3175381 gattgaggat ttaagagatg aaccaattat tactgttgct aaagaagcat ggcctactct 3175441 atacatggat tttattcagt tctgtgaaca agcgggcttc agacccaaca ttgtccagga 3175501 agccacagaa tatcaaatgg tgattggttt agtcagtgcc ggaattggta tgacatttgt 3175561 tccttcctcg gccaaaaaat tatttaattt ggatgttact tatcgaaaaa tggaccaaat 3175621 acagcttaat gcagaatggg ttatcgctta ccgcaaagac aatcataatc cgcttataaa 3175681 gcattttatt catatttcaa attgtcagca gacaagaact aaagagagtg atgcaggtac 3175741 atgaacaata cttgcaatct cttttttctt ttgggattct tatggaattt ttattaattt 3175801 aatataatcg cttagtacaa ctttatatca gtatacgtat acatacagta caaatagttg 3175861 gcaaggacat cagtaagcgc aggacattag tttgatttta aaaatgaaag atagagaggt 3175921 gaagtaaatt attgagttca ccggcatatt cacattgctc gcttttttcg taacaatgat 3175981 ttttattttc tggagaccaa aaggactaaa tgaagctatc cccgccacat ttggcgcttt 3176041 aatggtttta ttgtgcggaa gtgtgtcatt ggcagactta ggggaaatcg gaacaaaagt 3176101 cacgggtgca tcggttacaa tccttgccac tatgattatg gccattgcac tagaaagctt 3176161 tggtttcttt tattgggtgg ctgcaaaact gctccaacaa tccaagggtt caggcatcaa 3176221 gcttttttgg ctaaccaatt tgctctgctt tctcatgacc attttcctta ataatgatgg 3176281 gagcattttg atcacaactc caatcctttt gcttgtacta aaatatttag gtttaaaaaa 3176341 acatcaaaaa gccccatatt tattaagcgg tgttttaata gccacagcct ctagcgcacc 3176401 gattggcgta agtaatattg ttaatttaat ttctctcaaa atcattggaa tggatctata 3176461 tcttcacacc gccatgatgt ttgtccctag tatgatggga ctcattttta tgacttgtct 3176521 actgtttatg ttcttttata aacgtcttcc caaaagcctg ccagatatac cgggccattt 3176581 tcagtctctg cggcatagaa ggtaccatcc tcttcattcg ccatcagctc ctttaccaga 3176641 acgaaatcaa acaaaaatca tgttgtttgt gcttgcattt gtttttctcg tcagaatgag 3176701 tctatttgca gcatcatata ccggtatttc tgttcctcta gtcgctgtca tcggatcttt 3176761 tatcctgttg agctggagat ggatttattt caaaacctcc ccaagagact tgttatataa 3176821 atcgccttgg cacattttta tattcgcttt tactatgtat gtcttaattt atggtctgca 3176881 taatattgga ttcacagagt tacttgtgag ttattttgaa cctgtggttt ctggaagcct 3176941 cgcccatgca actttcgcat caggtatctc tacttcagtt ttttctaatc tctttaacaa 3177001 ccatccagcg ttaatgatca gtacttttac cttaactgaa atgaccctga atccttcaac 3177061 aacaaaaatc atctacttgg caaatattat cggcagtgat atcggttcat tattattacc 3177121 tatgggaacc ttagcaacgc ttatttggat gcatatatta aaacagcatg atgaaagtat 3177181 ttcatggggc gaatatataa aaacgaccat tatcatcatt ccgctgactg ttctttttac 3177241 gttaacatgt ttatattttt ggatcagttg gttatttctt tagcacagta tgaaacgaaa 3177301 aactgccttc tgcttttcaa gagggcagtt ttgtatacac tagggaagat gcattgtctt 3177361 tagatgattt aacttccaaa tgactggctc tccacttgcg ttaataagct caatgatatt 3177421 attagagaca ccctttaata gtccgacttt ttctggcacc tctcccatat caaatatgac 3177481 caattcacca atattttttt tgatctgctc ctcaaaatta cgcacaagag gaactttgga 3177541 aggcacgacc ggcaattgtg agttgtcaag agtatacggt gtttgttcag ttgaataagg 3177601 ggtaaaccat tttaaatgat gcatagatat aaaaagtatt ttaaatacgg gtgagaaaaa 3177661 tacaatataa tcgtttaaaa catttgtaac atatccatgg atcgatcgac ccccagttac 3177721 ataaacttca ataaactggc ctttgacctt gtttaatgta tttctatatg aaaaagcttg 3177781 agtttctgcc tctatcattg gatcttccgg attgatcaaa aatggcttct cagtactggt 3177841 cactattttc gccttgttta tttgatgaag atgcaacaag ggaatataaa gataattgca 3177901 gccatcaaaa ataacaaaaa tatcctgtcc gatatctatg agggtgccga caaaccttgt 3177961 atctcctgaa atgacaacct caacatctgt gttaaggaat tgattcaaac ctttcacgat 3178021 tctcctcctt taactgaaaa agggcatcac tttatctgat gctcctccat tatctattaa 3178081 aatttacgtt tccagtgata gtctatcgtt ctgacaatcg tttcatagct ataatcttcc 3178141 ttttgttttc ctgaactttt tattgaactt gaatagcctg gtgatcttga tgattgataa 3178201 tctgaagatc ttggtgatcg tttagatgat tttgatgatt gataatctga agattttaat 3178261 gatcgtttag atgattttga agaacttttt gaacgtgacg aacggccaga tttggatgat 3178321 tgataatccg aagattttag tgatcgttta gatgattttg aagaactttt tgaacgtgac 3178381 gaacgaccag atttggatga ttgatcatct gaagatttta gtgatcgttt agatgatttt 3178441 gatgagctat atgattttga agaaatgaac gaattgctgt ccttatcatt attgtcttcc 3178501 tggttttgtt catttttttg atcctctttt ttgtacgacc cttttggacc taagctgatg 3178561 ctttttatgt gaaaaggata gatgcgaagc acctcttgat ttttcactat agtataatgg 3178621 ccgtcggcat tatctacaag gataccctca atggcttccg gacctccacg attaattgaa 3178681 acccatttat gagtcagact cttaaaaacc tcgcttaaat catcagcttc caaaactcca 3178741 actggcgtct gctcttctat tttcaaatca ggctcgtgtt tacttatact tttgatgtga 3178801 tggatattaa aatacactac cccatcctca tttgtgttta acgcagcgta atcatctccc 3178861 agccagacca atcttccttt tttagattcc ggaccccctt ggttaaattg aactgattgg 3178921 tttattaaat gtccgattaa gctatgaaaa tcatcagcat cgagcatttc ctcagtctca 3178981 attgttgtgg tgctattatt ggtatcctca gtaatacttt tcacatgctc caactgataa 3179041 taaattattt ttttttcagc ttgtaaagct atataatctg attttacagc tgttaatttt 3179101 ccttttttag attccggacc tccacgatat acagtaacaa ttttatcttt cattgagtgc 3179161 aaaaagttat aatacgatat ttcattattt gaatgatatt tcattctcct cttgctcatt 3179221 caaattcctc ctagtcactt atacatagat gataaacata ctgcatatat acgtgtcaca 3179281 tttatttgtt gaactaattc aatagcctaa ttgtcgcttt ttccgcgaat acccattttc 3179341 acgcattcat aaaatactta aatgatcttt gaggtattgt gaacggtttt taatatactc 3179401 gcagatcaca tccggctcac ggtcaaaacg ctcaatatca ttctttttat acgggtccat 3179461 gaggacaaac ggcctaatcc gttcatacat cgccatgatt ttcggttcca tatattctat 3179521 tgtaaaaaga gattggagcg ttttttctaa caggcgcttg taggacttgc gaaactcgga 3179581 ttcatccaat atccgggcgg ttagtgtatt aaatccttga attcttacat aatcggcagc 3179641 catccgctct ccatggatat ccctgcccca agtcgcatca taatcccaag gaatcacctc 3179701 aaataatccg gtttccccgc ttctgtataa tgcgtagttg tggacaaacc cgtcatagtt 3179761 cgaggtgaat acaataccag caagccagcg caaatactta tcgacatcca cgtgttttgt 3179821 cacttctgac ttaaactgag ctttagggac cgtattaatt ttaaaaatca tatcttgtaa 3179881 ataaaaatca tcttcctcag tccctgtttt cttttcatat ccaagctcca gcgatgtttt 3179941 cgtttccctt tctaaatcgc tcatcagaga aaagttggca tcatcatcca ccgcataaaa 3180001 aatcgcgcca tcagccagct tccttttcgc caaataatat tcatctacgg attcaagttc 3180061 aagataaacc ccttcattct tcccattcat ctttacaaac gcaaactctg cctttggaga 3180121 cagtgtccct agctccgaga aaaaatccag agacaatttg tttctcatca aggaagggtc 3180181 tttatactcc gcatttaagt gaatctctcg cgcgccgcgg aatgttttcg gctgataaaa 3180241 ggaaatatgg tatgacttct ttttgaagtc tctgatatgt gatccccgat aagcgatatc 3180301 aatatccagc cttttttgat ttaccttcat cacagctggc accggatcat cgtcccatat 3180361 atcctttttt aattcacgca agtcttttgg atgaacaaac agctgataaa gcggtaaatt 3180421 ggattgattc ttcatccata atcctcctta caaattttag gcttttattt ttataagatc 3180481 tcagcggaac acttatacac tttttaaaac cgcgcgtact atgagggtag taaggatctt 3180541 catccttaac atatttttaa aaggaggatt tcaaattggg ccactattcc cattctgaca 3180601 tcgaagaagc ggtgaaatcc gcaaaaaaag aaggtttaaa ggattattta taccaagagc 3180661 ctcatggaaa aaaacgcagt cataaaaagt cgcaccgcac tcacaaaaaa tctcgcagcc 3180721 ataaaaaatc atactgctct cacaaaaaat ctcgcagtca caaaaaatca ttctgttctc 3180781 acaaaaaatc tcgcagccac aaaaaatcat actgctctca caagaaatct cgcagccaca 3180841 aaaaatcgta ccgttctcac aaaaaatctc gcagctataa aaaatcttac cgttcttaca 3180901 aaaaatctcg tagctataaa aaatcttgcc gttcttacaa aaaatctcgc agctacaaaa 3180961 agtcttactg ttctcacaag aaaaaatctc gcagctataa gaagtcatgc cgcacacaca 3181021 aaaaatctta tcgttcccat aagaaatact acaaaaaacc gcaccaccac tgcgacgact 3181081 acaaaagaca cgatgattat gacagcaaaa aagaatactg gaaagacggc aattgctggg 3181141 tagtcaaaaa gaaatacaaa taatctaagt tttcattgtt tcaataggct gccggcggag 3181201 gtacggaagc ctattttttt atttgccctg tattagatat atgtcatgac ataacatatg 3181261 caacccgcat catttggttt cctttaaacc atttcgttat aatcaaggta tcctaacgat 3181321 aaaggcggtt gttgctatgt acatatttca agctgatcag cttagtgcca aagacacata 3181381 caagctattg tcaggtaccg ttattccccg ccccattgca tttgtgacaa cactttcttc 3181441 aggaggagcg gtaaatgccg cgcctttcag tttttataac gtcgtcagct cagatcctcc 3181501 gcttctcagt atttctgtta acaggacgga aggacgccaa aaagatacag cacgaaacgc 3181561 agtggagaac ggagaatttg tcgttcatgt cagtgatgaa gccatcattg aagatatcaa 3181621 tgaaacagct gcaagcttaa ggccggatga aagcgagctt acacgcacct cgcttcatcc 3181681 tgttgaaagc aaagctgttt cagttcccgg cattaaggaa gcccgcgttc gctttgagtg 3181741 caaattagag cggcatatta cctttgacaa tgatcaaggc atcactacag cagatctgct 3181801 catcggaaga gttgtctgct tccacctaga tgaaaaggtg tatgatgcag aaaagggata 3181861 tattttaacg gatgaattaa agcctgcctc acgattggcg ggaaatcact atgccaagct 3181921 gggggaagaa ttcacactga ttcgtcccag ctgaagagaa ggactattta aatagaagaa 3181981 actagtcaaa aagaccttat gattacaaaa tatcgcctgt aaataactga aaaaatatca 3182041 aaaaaaagaa cacccagagc aagctcgggg tgttctttta tgaaacgttt ttcctttttc 3182101 ttcgtataaa ggtagattag gaggaattgg aatgacaaac ttttggattt taatgctgat 3182161 cgctattacc atcagtctcg cctctcaatt ttttataaag aaaaaatacg gtattgataa 3182221 atccggctgg cgatataagc atgtcagcaa tacacacaaa tggatcgaaa tcactttact 3182281 tattttgttt gtgttttcac tctccttttt tccagttgaa tatttgcttc ttttattttt 3182341 tattgtgatt gactcaatac gtatttttat ggagtggcat tatagacctg aagataaaca 3182401 gtatatgtac cacattgtag aggtctccct tatgtttatg cttttgattt atgtttgtac 3182461 cctatagtta tttaaatccc cacagccgct ccgtctcccc gaggatcggc tccgccttgg 3182521 agaaagcctt cttcatcaac tttgattgca gccgcttgtc ccatcagcgg atcatagtca 3182581 ccgacaacct ccacgagatg cccgctgtct ttcagttttt ggattgtttt gtctgtgaat 3182641 ctgccctcga ctctgagacc ttcgtattcc tctccccacg ttctgcccca tacccagcgc 3182701 ggttcgctga ttgcctgctg tggatgcatt ccgtagtcca gcattcgggt aatgatggcc 3182761 gtctgggtct gcggctggcc ttcgccgcct tgtgtgccgt acagaatttt tggctttccg 3182821 cctttacaga ccatagccgg catcaacgta tggaaggtgc gctttctcgg ttcaagcgtg 3182881 ttgacatgat tttcatccag tgagaaaaac gatccgcggt tttgcagtaa tatgcctgta 3182941 tcaccggcag tgactgccga gccaaattca aagtacaggc tttgaatgaa tgacactgcg 3183001 ttgccatccg catcgattac ggccgcatat gccgtatcac ttcccaccgg cctgctttct 3183061 gccggtattg cgagatagcc gatttcttct gccaattgtt ttgcataacg tttgtccaaa 3183121 agcctttcaa gcggaatgtc tgcaaacgcc ggatcagtca ggacggcatc ccgatctaga 3183181 aaactctttt tcaatgcctc cacaagcacg tgataatact caaatgaacc gtgttcgatt 3183241 tgggtgaaat catagttttc caaaatgttc agtgttaata aaccggtaaa tccctgagaa 3183301 ttcggcggcg cctgatacac actgtatcct cgataatcac ttgatacagg cgctgcccac 3183361 tcaccccgat gcgctttaaa atcatcgatt gtcatgtaac tgccgttatt ctgtaaatgt 3183421 gagacaatcc gctgagcgag atctccttca taaaatgcgc ttcttccttt ttcagcaatc 3183481 aagttcagac tgtctgcaag ctctttttgc acaaaccgct ctcccgggac aggtgctttg 3183541 ccccttctcg tgaagatgtc agccgtgtaa ggcgtggaag ccagcagttc aatattcttt 3183601 tctgtgtgac gacactgatc agctgataca ggaaacccat tttgggcata atcgcgtgcg 3183661 ggctccaata catctgcaag agacagacgc ccgtactcct tcaggaccgc atcccagcta 3183721 tcaaccattc ccggcacggt aatagcactg tcaattcccc gcagcggaat cgcgcttttt 3183781 cccttatata catctctcgt tacgtttttt cctgaacggc cgctgccatt gtagactttt 3183841 actgcctttg tttcctggtg aaaggtcagc caaaaggaat ccccgccaag tccggtcata 3183901 tgcgggtaca caaccgcaag acaagcactc accgcaacag cggcgtcaaa cgcgttgcct 3183961 cccttatcca gtatgcggtt tccggcttga gaagcgagat aatgcggact gacgaccatt 3184021 tgctttgtac cgatgacaga tttgttcatc acaagtcccc ttttttaaga aattttcttc 3184081 agtataggga gcctgatttt tcacatctac tgatccggca gaaaaactga cgaactttct 3184141 tcttttcgca aataataaga tattttcgca ttcatttcga aaacaaatga aaaattatta 3184201 tttctatacg taacttttat gataaaatga ttgctaaaag gctacgaaag caggtggagc 3184261 aattgagtca tgaatatcaa atccccaacc ttgtacttga tgagactgat aaacaaattc 3184321 tcacgatttt gcatgaagaa ggcagaattt cttatacgga tcttggcaaa agagtcgatt 3184381 tgtcacgggt cgccgttcag gcccgtatca accaattaat tgaagccggt gttattgaaa 3184441 aattcaccgc tgtcatcaat cccgctaaaa tcggcatcca tgtttccgtg tttttcaatg 3184501 tcgaggtaga accgcaattt ttagaagagg tcgctcttaa gcttgaggaa gagcctgcgg 3184561 tcaccagcct ttatcacatg acaggcccga gcaagctgca tatgcatggg atctttacca 3184621 acgatcaaga aatggaagaa ttcttaacaa aacggctgta tccattgcga ggcgtcgtca 3184681 gtgttgattg ccagatgctg atcaaacgat acaaaagccg tatgggaatg aagctgtaaa 3184741 ggagagaaac aaatgaaaaa ccatccttat cgggatatga cggccgcaat ggttcgcacc 3184801 ggcatattag ggttcggcgg cggaccttcc gtgattccgc tgatccgcca tgaagcggtc 3184861 aataaatata aatggattga cgatgatgaa ttcggagaaa tattagcaat cgctaatgcg 3184921 cttcccggac cgattgccac caaaatggct gcttatctgg gctttaagct aaaaggcaca 3184981 ttaggtgcaa ttgtggcgat cctcgcccac attctgccta catgtcttgc gatggtgggc 3185041 ttgtttgcgg ctgtaaatgt gttaagccat tcagcaattg ttgcaggtat gattggtgcc 3185101 gtcacgccgg taattgcggt catgctcgga atcatggcgt acgagtttgg ccaaaaagcg 3185161 cttaaaggtt tcggctgggt taccggcatc ctgtttttta tcatcgcttt tatcggcctg 3185221 caaactttac agattaatcc cggcctggtc attatcattt tcttagctta cggggcgttt 3185281 cattttaaac tgaaagacaa aatcacaaat aaacattcaa aagataaagg aatgtcagcc 3185341 tcatgatatc gatctattta tttatggcgt tttttatcgc aaacctactg ggatatggcg 3185401 gcggacctgc gtctatcccg ctaatgtttg aagaagtcgt aaacagatac agctggctct 3185461 caaacgatca attctcaaat atgctcgcac ttgcgaacgc attgccgggc ccgatcgcca 3185521 cgaaaatcgc tgcgtatgtc ggctacagcg caggcgggtg gcccggcttc ctaattgccc 3185581 tgatcgcaac cgtcgtaccg tcggcgctcg cattgatcgt cctgctgcgc atcatccagc 3185641 gcttccgcca atcacctgtc atcaaaggca tgacgctgtc cgtccagcct gtcatcgcgg 3185701 tcatgatgct cattcttacc tggcaaatcg gcgcagacgg catcaaagcg atcggctggg 3185761 tccaatcgat cgtgattacg ggaatttcgc tccttgccat gacaaaattc aaaatgcatc 3185821 cggcattttt gattattgcg gcgtttttat atgggggcct tgtgatccct tatttataga 3185881 aaaaagcacc tggacaggtg cttttttatt ttagcccaga aatgccgttt gatatgacag 3185941 ctgtttcttc tcctgcgtca ctcttgatca tgtgcttgac ttgcagcgtg gttcctgcca 3186001 ttctcacaga ttgcttcaac tgggacgaat tggtttcaac ttgtatccaa acaggaggct 3186061 ggaccttcca aaataaatag agtgcaagaa tcagcaagcc agcaatgacc gacagcaaaa 3186121 acttcatatc gcatcgcttc ttttcagtaa gcggctcgca gcggacagcg cctgatgatc 3186181 acgaagaata tcgcctggac gattgccttc tcccagcaca tagcctttaa aggacattcc 3186241 cataaaatga aaaatatgtt cgaattgctg aatcagcggc agccctttta tttttggatt 3186301 gtctccgccc actgctatta catatgcctg tttcactgac atttgctgtt taaaatcagg 3186361 aaatctcgga tctctcaacg tctgtgacca gcgatcaata aacagcttta atgtccctga 3186421 catgccaaac caataaattg gggtggcgaa tataagaata tggcactgca atatccgttc 3186481 aatgatagaa tcgtagtcat cttgaacagg acgaaagccg ccttgggcgt gacgcagatc 3186541 ttcaattggt tgaattggat atttctgcaa ataaatgtgc tccgcatcga atccttgaac 3186601 agccttctcc gcaagaacat ccgtatttcc gccagaccga gttccgccgt taataaccgc 3186661 aattttcatg atgcatctgc tcctttgttt acgaatgatt ttcttcatca tataatggat 3186721 tcatcaatca atacagatga ttatttcgat taatccaatc gctaaaaccg atttagaaag 3186781 gaagagaaca agtggaattg aagcagctga tcacctttat tacggcggct gaacatgtaa 3186841 acttcaccct aaccgccaaa atgcttaatt atgcacaatc aagcgttacc tctcagatca 3186901 aatcacttga agaagaaatc ggaacgcctt tatttgaacg gctcggcaag cggcttatct 3186961 tgacagaagc aggaaaaacg ttcaaatctt atgcacagaa gatcattgcg ttaacagaag 3187021 aagcgaaaat ggccacaaat caagtaagag aaacaaccgg aaccttaaaa atcggggcga 3187081 cggaaagcca gtgcacatac cgcctgcccc ctatcataaa agaatttaaa caggcttttc 3187141 cccaagtaaa gctcatattc aaaccatata tctccaatga acaagcgaaa gaacagctct 3187201 tacagggcca gcttgatatc accttcatct tggatgtaaa ccggatggaa gacgcactgc 3187261 acgttgaatc tttgattcag gatgagatca aaatggtggc tgctaatgac catccttttc 3187321 ctgcggattt accagtaaca ttgaaggatc ttcaaaacga aactcttctg ctgacagagg 3187381 acggctgctc gtaccgcacg ctctttgaga acaatttgca tgactccggt atctatccta 3187441 acaaattgga attcgtcagc atagaagcca tcaaacaatg cgtgatggcc ggacttggga 3187501 ttggaatctt gcctgaaatg acagtaaaag atgatattgc agcaggccgg atgaaagaac 3187561 tcaattggca gagcgattgc cccgttttca ctcaattagc atggcataag gacaagtgga 3187621 tgtctgcgcc attaaaggct tttatcgatt tgacacggaa aacattcaaa taaaacctct 3187681 ccacaaggac gacaaggttt ttgagaccag ggcacacaca tacaaaaaaa acacttgatg 3187741 acttagagcc ccaagtgtta cacgtgattt ttctgataaa acgttcgcaa aacatgcgtc 3187801 tcaaggtcag ccaggcggac agggatcggc agcctgcttt cttgattgat caagctcatc 3187861 gtgatctgat agctgctgtc taaatcaata taattaccgc aagacaagaa aataggcttc 3187921 acgtcccgcc gcgttcgcag cgcccgtcca tatacctcgc cgtcaatgat aatatcggtg 3187981 tatgcgccta cttcaatttc aggcgtcacg aaatcgcagc ctttgatttt gagataggtt 3188041 ttcgctatcc caatcgtcgg cttgcccaga aaaaaagccg catgggtggc aacgcccata 3188101 tgattgtaat gcagatatcc gttgccatca aacaagaaga catccggctc cgtctccagc 3188161 tttttcgccg cctcgatgat caagggcagc tcgcgaaacg caagaaaacc ggaaacatac 3188221 ggcacgctga ttctccccat gctgtgcact ttttcaatga cttcttttgt atcagcgtca 3188281 attacgataa tacagcacac tccgtatggt tctccatcct gctcccaata ggccaggtcg 3188341 acgcctgcgc aggtgttgat ggagtctgga tggatcgtgg gggataggtt gatacgattt 3188401 ttaaggttaa attgcacttg taaaaagtct tgttcctttt tcatatcaaa tttatgcaca 3188461 tcaaatacct tcataacgat tgctcactct cgacctaaat taatgtgagt ctctcttctc 3188521 gattctagta tttcaaaatg aggactatct gtatctatct cgtacttatt taatagattg 3188581 ccttcttcat cccaattctt ttcagaaatt agtatggaat gctcatactg ttgctcactt 3188641 tttttcctgc cattttcaaa ccaaattatg cttataccgt gcaattgccc atatcggtat 3188701 tctttttcac tttttttatt cccgttttca taaaattcac atgttaaacc atgggccaga 3188761 ccattcttat atttagtaaa atagatgatt tgaccatttg gatataattc gtaagccagc 3188821 cctgtaaacg gctggccatt ttcgtcttca ggattatcta aaatctcatc acttaccgaa 3188881 gagaaccata aatcctcaaa gtccactccc ttttctttta tactcttcat atcatattca 3188941 ttttccatac tttaaagcct ccggtatata atttgtattt tgagttatat attcacaatg 3189001 tggacatcta ggcattggga caccttctgg catcttttta tttattttcc tagcacttac 3189061 tacatatacc attaaatctt ttaaatccgc atcaggtctt tgaagtaacg cttcatttag 3189121 agcattaact tcggcatgag aacccgcccc tgacgtcttt atataacctt ctttaagttc 3189181 tgtaggcata tttacaattc tatcatgaat aagtggatgt agtaccttag gtggcttccc 3189241 atctatattg tttattccaa aataataatt gcctgttttt ttgtccaata caccagctac 3189301 cgcagggcct ctttgttttt tagttagacc agaagattta attctactaa gttcgtttag 3189361 tacttctgcc cttagattta ttcgatggtg aagatcttct ttagacaata caccatgctt 3189421 atttcttaaa tattgaagcc tagtttgttt ttcttcagta gtcttagcaa tattgctaat 3189481 aaggctttca ttactcactt tattgacata tggagcattt ttttggtaca accgatcaaa 3189541 gtagtgtgcc aatcctgctc caccaataat agtaatagct tccagcgccc cttgcttccg 3189601 cttctcctca gacactttgt ttccgaacat atcccggcct gtgacagctt ctgagaatcc 3189661 gtttgacgca acaaggccgt atgcgcccat ttctgtcatt ttgagaatgt ctaaggattt 3189721 gcctgttttg taggcgtcta atgcgtgttc agcagcgata gctgcttttc cggttttgta 3189781 gatggctttt ccgcctttga aggcccggcc tgcccagccg acgactggta tgaatccggc 3189841 agcggccata gctcctgctg tcacacgctc cgcggtggag agtttttctc cggtaaccgg 3189901 atcaacgcct tcggttgctc ttttataatc ataatagcca gtgacttctc cagtaaagtt 3189961 gcaaactcca tcccatgttt tttcgtacca cggtttgttt gcttcttcct cggctttttc 3190021 ctggagccgt cttgcttctg cttgctgggt ttttgcatcg atataggttg ttccttgatt 3190081 ttctacttca atgacgcttt tgtagacttc attgctgtgg aaggcttttt tgtcatagta 3190141 cataggggat gcgctcttcc cattgctggt ggcctgcatg agaacagaat atttggtgag 3190201 cactgcgttg tccagagatt ctaaattttg atattcagtg gtcagggatt catcaagctt 3190261 atcgacagct gtgattgtat cacgtctgat tttttgggca tcgcccatct tatctgcata 3190321 gtcgtcaagc gtgtacatgt cgagatcaat aatatcgctg atgcctgaca aaatagaatc 3190381 gatttcttct ttatgagcgg agacaatctc tgaggctttc aggtctccat tgggcagctc 3190441 atgatccaaa aaagaagttt ccacatatga atcattcagt tcttgatctt taatatctcc 3190501 tgaaatgccg tttaaaaacg caatttgagc agagacaagc gtcagccagc tgtctacgat 3190561 ttctgcctgt ccctgaaaaa aatctttaat attgtccgcg ccatttcctt taaaattatc 3190621 gcctaaatcg gcaactccct gaaacgcttt tttcagcgta ttcagctgct cttcaagcgt 3190681 ctcatattgc ttttttctgc tcttcgcttc ttcgattaaa gattttgatt caaatacttt 3190741 actcatcgca ctgccctttc tgttctattt taccgctatc gcctcgtcct gctctttgag 3190801 tgaatctacg ttatcctttg tatcctcgat atttttctgt accgcttttt tgtaatctcc 3190861 gagcatggtt ttgatgttct cctcacgctc atggtatttt ttcgtataat cgaggctgtt 3190921 ttttccgttg gatcctgcgg cgccgattga tacgtcagca agcgcatctt tgacagaatc 3190981 taatgttttg atgactgtgt cgtacttcag cttaatttct gacataaaaa aagatcacca 3191041 ccattttagt ttactaattg tatttccgac ttcttccgcg aactcttctc cctttttaag 3191101 aagatctgct gcaccatttg ctatgaacaa ttccgatgca tatttagctt tatcccattc 3191161 aagatcaaaa attttcccgt taatcgaagc catatactcg ttatatttat cattcacaat 3191221 cttagatgct tccgatttcg cctcttctct tcccttgtcg aaatcatcgg cttttgttcc 3191281 cgtccaatgc ttgcccaatt ccggtttcac aatttctttg atttcagtga ttgcctcttc 3191341 ttgcagtgtg tctatgtcct tttttgcttt tttcagcttt tcgatcttgt cttccacgtc 3191401 tgaaattttt ccgttgagcg aacttttgat atccgctagc atactttcat aacccatctg 3191461 aatcacctct taatactcaa aaagtcgtat ggaggggctg atgaagatag acttttccat 3191521 actttatttc catatattat attttaaaat agccagaagg cggcttaaat agggtaaatg 3191581 gcttaattta ggcatataac gctcttgaaa tgtaggtatt tgatcttgtt tttgttcgtt 3191641 atacagctaa taaaagcgtt ttataaaatg aaatcaccta atgtcatagt tataaaggca 3191701 cttgaaagag gcagatgttg ttgatctgcc tctttcggcg ctgagcttat tgttcatgtt 3191761 tatgttcttc atctggtcgg ccatgtctga ttttgtcatt tggcttctat tattcccccc 3191821 ttctgaccct ttggatcaaa agcttgtatt agctgcagtc ccagttgtac agaacgtttg 3191881 aaaagtcttt tttccttaga tcttcaggtg tgatgaaaaa attggcgatg ccgacgtctc 3191941 cccacattga atcgatatca tcgtctgaat caatttgtaa cagcatgatg gtgtgttctt 3192001 tatatgcgta ttcccgggga tcatgctggg taaaagaagc gtatccgcca attttatggc 3192061 caaatccgtt ttcagccagt tcattataaa tgtcttcttc atcctcgccg aactgaccaa 3192121 agaactccat tgtttccatg cccgtatact gctcaaattg aaaatctgta ggcagcaccc 3192181 attccgaaga tttcacaggc tcgactgccg cttctgataa aatcggaaaa tcacattcgc 3192241 ctgtgccaat aaatgaaaaa tcagaaacaa gctcgtcatc gttttctacg atattttcaa 3192301 aatagatcac tctgaaattc ttttgttcac atcgatcgtc aaaattcaat ccatagacgt 3192361 catcatgaac agaaatgtag aactgcagga tacctgaaga agggtagccg tcaagctggg 3192421 gaatgtgcga gaaattaatc tgcgccagaa gtttcatcgg ctgtccattt tcgtcagtcg 3192481 gatatgtttc atgcttgggg aaatagggat caccggcaat tttgctgtca tatcgtcctg 3192541 ttttcccctt tctcacattc agtttcacgt attctttcgc tgatttctcc agcaagtcgc 3192601 ggtacggtct cattttttcg ggcagatgat tcatcagatt ctctcctttt ccggcatctc 3192661 caaggtttta ttttctggtt ttcttctaat gtttttcaaa cgaatgttta aagaagccct 3192721 acttctgcat aattttccaa acaatagtta aatagtagca aatgtattca gcaccccgca 3192781 atagatgaaa aaaagactgg tgcgcaacca gcctttcttt ttcatctatt gaattgcacc 3192841 tgacggaaca accgccttcc gtccgacaga ataatactcc actcctgcag ccaaagcctc 3192901 atccaatgtg tagcagtttc tgccgtcaaa tatgagcggc gtttccatca aatcctgata 3192961 agccgctaac gggaattgtt taatgtcagc ccagtcggtt aaaatcatga cggcgtcaga 3193021 ccctttgaca gcttcctcga tcgtctcttt atattcaaca gcttgcggga gaacatgctt 3193081 tgcatggcta actgcaatgg gatcgtaggc tctgatacgg gcgtcgagcg cagcgagacg 3193141 gtctgcaata acaattgacg gcgcttctct catatcgtcg gtattcggtt taaatgacag 3193201 gcctaaaagg gcaatcgttt ttcccgtcac cccaccgagc ctgttcagcg ctttatcaac 3193261 cagcatcgcc tgctgattgt tgttgacttt gataacggat ttcagcagtt caaaatcatg 3193321 ctcgacattg ccggcaattt gcacgagggc gtttgtgtcc tttggaaaac aagagccgcc 3193381 gtagcctatg cccgctttta aaaactggct cccgatccgc ttatcctgtc ccatcccgta 3193441 tgcgactgct tcaatatcgg cgccgacctt ttcacatata ttcgaaattt cgtttataaa 3193501 actgatctta gtggccagaa aagcatttga ggcatatttg atcatctcgg cgcttctgat 3193561 atccgtttgg taaatcggga tttgaaacgg acggaagagc tcctccagcg tatttgctgt 3193621 tttctcatcg gccgtcccga tcacgatcct gtcaccatga aaggtatcat agatcgccga 3193681 cccctcacgc aaaaattccg gattggatgc gaccgaaata ctgacaggct ccgctagatg 3193741 ttcagtaatc agtccattaa tcaaatcgtt tgtcccaacg ggcactgtgc ttttcgttac 3193801 cacgactgta tctcgtttga catgctttgc gatgcgtttg gccgcatctg taatttgctc 3193861 cagattggcg tgcccgtcgc ttttctgcgg tgtgccgacc gctataaaaa tgatgtctgc 3193921 ctgtgccaag cctttctcat agctcgtttc aaagttcagc cgtccatcag ctgtattttt 3193981 tctcatcagc tcttcaagac ctggttcaaa tatgggggaa atgccctttc tcatttcatc 3194041 aatcttgtga gcgtcaatat caatgcaggt tacatgatgt ccaatctcag aaagagaaac 3194101 acctgtcaca agaccgacat agcctgttcc gatgactgtt atattcattg tttccctcca 3194161 acagttaaat tgctgctttg cagcttccgt aatatcgtat gagaacatcc tatcatgaat 3194221 gcgaatgatc tcccgcatag cctgtcgggt acagcctgta cagatttctg aaatgtgatt 3194281 caaccataca atacactatt atatcgctct caaaaagaaa gtggtgaaat gagaatcggc 3194341 tgttaaaaaa aaccaaacaa ttttcttctt ttgaccggct gcggaggctg tctgaagatg 3194401 gtctgattcc gcaggagaag ctctgcattt tccgtcagca tataaggaag ttccgagccg 3194461 aattctttct ctagaacata aagagcctct tgagtgtgaa aatttctcgt tttcacatta 3194521 tgggcatctg aggctacgaa atggatcaaa ttggcttcaa ccagccggag agaaaatgct 3194581 ttcagctgct tgccgaagat ccccgcaaga cttcctgaag taatctgaga tgctgctcct 3194641 ttttccacaa gatgatacag caaggacggg ttttcgcgaa tttccctgtt gcgttcagga 3194701 tgggcgataa ccggaatata tcctttcagc tgcaaatcat aaaaaagctg ctccgcatat 3194761 cggggaacgt gatcaaacgg aaactcaatc aagatgtatt ttgtatcatt cagcgaaagc 3194821 agctgacgtt tggcaaggtc ttgttccacc tcgccgtaga ttctgatttc ctgtcccgga 3194881 agcacatgta aaggaatgtc ttctttgatt aaacgtttgt ttaactgatc tgctgcttct 3194941 ctgactgcgg ctggctcgtt tttatacaca ccgttgttat gatgaggtgt cgcaatgatc 3195001 gtccggattc cctgacgaac agctgctctt gccatttcta tgctgtcggc cgaatcacct 3195061 gccccgtcat ccattgcggg aagaatgtga cagtgaatat cgatcatgtc ctagccccct 3195121 tttttcgcaa aaataaataa cgggcacgat gcacgttatt tatttttgca tgaaattgtc 3195181 cttggttccg taatatccgt attcagagtg cttcgaaagc tttttgccgt tcataatcgc 3195241 cccaaggagc ttgcttttgc acgttgcaag cgcctctttc gcttttgcgg cttgttcttt 3195301 ttctgttttc ccgcttgaaa taaccagaac agaaccgtct gccacgttgc ctaaaatctg 3195361 tgcatctgct acggcaagaa taggcggcgt atcaaaaatg accatatcat atgccgcaca 3195421 cgcttcgtat gcaagctcct tcatccactt cgaggagaga agctcggccg ggtttggcgg 3195481 gatcgggccg ctcgtcagca cgtcaagatg tttttcattc gatgcttgta cagcctgctc 3195541 catagagctt ttctttaata aaacagatgt taagccaacc gtattttcaa gaaaaaaagc 3195601 cgtatgtact gttggttttc gcaaatcagc atcaatcagg agcacttttt ttccctgttg 3195661 ggcgaatacg acagccaggt tggcggccgt tgttgatttt ccttcccccg gacaagccga 3195721 tgtaatcatg actgatttca tttgccggtc cactgaagca aattctatat tcgtgcgaat 3195781 cgtccgatat tgttcagagt tcaaggattt cggctctgtc attgcaatga catttctctg 3195841 catccgcgag cctctgtttt ttctaagcgc caaaatgtcc actccccgtt ttttcagatt 3195901 ggaaaccctg taaggtcttt gctgttttct gctcattcgc aatggtggaa actgtcccta 3195961 aaacaggtat gtccagcaag gattcgagct gctcttccga tttgatcgta ttatccaaat 3196021 gctcaagcag gaaggccagt ccgatgcttc ccgccaatcc ggccgcaaac gcgatggcaa 3196081 tgtttagtag cggctttggc gatacagggg acgggtgttc tgaaacctcg gcttttgaca 3196141 gaatgctgac attgtcaaca ttcataatgg atgtgatttt gtcttgaaaa acagatgcta 3196201 tagtattggc aatatgagcc gctgtttccg cgttttcatc cctgactgat atgttgacca 3196261 cttgggagtc ctgttcgctg gatacggtaa ttttgtcatt cagttcttgg gatgtcatcg 3196321 acaggcccat ttctttaatg acttcatcta agatggcagg gctcttaatg atgacattgt 3196381 acgtattgat taactgaaga ttggtttgga catcgttaaa ttggacttct tttcgttcat 3196441 ttttcgattg gttgaccaga atctgagttg aattttcata gatgggtgta agtgcgaaga 3196501 aactaatgag tccgccggca gcagtggcag ccgcggttac aatcataatc aaaagtatgc 3196561 gttttgttaa cgttgataat atctctttta agcttgtaga ttctcccatg atacctccaa 3196621 atctcttata acatcctttt ccatctacga ttatacaacg ttgaaaccgc atttctccag 3196681 cttttcacgt gacataattc gacatttttt tacaatgcgt tatgttagta ctttttatgt 3196741 aagcgctata tttactgtgt tgacagtgct gtctcatttt ctcttattcg ggcagtcacg 3196801 ttctctcgca taaaaaaatc ccgctaaagg cgtgcgggat ttttatgttg catatccatt 3196861 tttaatatga gaaatcaaat tttcaagcat ttccttcgtc gtcatctcag atgactgctc 3196921 accaatttca tgtgcatgca tcaaaatttt cagaaattct tcttgattca atttcttttc 3196981 actcatcttt tttttccttt cagcttccat taagttgaaa acacgattat tatatgatgc 3197041 tggttatcaa tttgcaatct ctaatacatc attcgacaca tcctattttt tatgtccttt 3197101 tttaggaaaa actttttaag gccgatgtgt tgcgatataa tagagaaatt ggatcttttt 3197161 attacgtgac tcggttagga gcgataatca tgcttcagaa tatgatttcc aaagacgatg 3197221 tgctggcatc tgctgaacag ttaaaagaac ttcttcctta caatgaggaa aatgttcagc 3197281 tgatcaaaaa agcccttatt ttatatcggc aggattcagt ctatcgttta caagcagtga 3197341 gtccgacgga agttacggct tacgtgcagg atgttgtgcc tgtgcgggtc acattgaact 3197401 tgtttgtcat agtcaaaagc ggctgttcat gtccgtccgg aagaatctgc cgccatatgc 3197461 tggctgtgtt tttatatgta tatgcaatgt tcgagcgagt gggtactttt acagagtatt 3197521 ggctggagag ggaaaagctt gaggaaagca aagagctcgt ccgccgccag tttcaggaaa 3197581 aggtgctgcc taatgaagaa tcactttcaa gctggcttgc tttttttgat tcagagtttt 3197641 ctctctggca ggcacgtacg ccagaaggca gccaaaacat gcagggcctc tattacggct 3197701 acctgtccgc attaaaaaaa catgcgccga acaagccgga gctgaaaagc ctgtatcaga 3197761 ttcattccgc gattgcggtt tggcttcgca tgttcacatt gattgaagcg ggcaagctaa 3197821 accccgaaca agatttttat tccctcaatc cgtacgttga acagctgatg gatacaatct 3197881 acagctctat tgataaatta aaaacgtacg cgctgtcttt tgcgcttgat ccgtttttgg 3197941 ataaaacacc ggatgttatc cggcatttgc tgttgaaaga agaaattttc caatatgaac 3198001 gcatccgcgt cttcggtgaa atttggagtg cgctgctgtc gcggccaaaa tgggtggcac 3198061 gcgaacagga gatattgaaa aaagaagcag gacggcgttt ttctcccgaa ttgcaattcg 3198121 ggcgcctgca tttggaattc ctgcaaaaaa atgatgacgt tatttttgag gaagcggatc 3198181 aattcccgcc ggaagcgctc ccttatacat tccaatggct gagtgaaatg actgccaaga 3198241 aggactggaa acggcttaaa acatggtacc agcaaattga accaattgcg atgggttata 3198301 cgaagctgga taagccgttt aaagagattc gcgatgtgat cggcgagctg ttccttctgt 3198361 tgaatgccta tgtgcagcaa accaatgatc aagcgctgtt tgagcgcttt gccgcgggct 3198421 gtctgccgta tacgttcaca gaatacagcc atcatttata tgaaaaaaaa cgctatgccg 3198481 agtggattga aattcatagc cttgtcggct tttccatcaa tgaaatggat aaaatgatgc 3198541 tcaaggaaat tgcagcgagc gaccctgagg cgcttatacc ggcttaccat agagaagtgg 3198601 cttttttcat tgatcagaag aaccgtagct cgtacaagga agccgcccgg tatttgaaaa 3198661 aattgcgcac cctgtacaaa aaagcgaaaa agcagaaggt gtgggagcgg tatattcagc 3198721 tgctgagctc gcattacaag cgcctgcgtg cgcttcaaga agaactgcag aaaggaaagt 3198781 tgattgatgg cgagtcttaa agaaattctc atccacgtcg aacaaatgga agatgggtca 3198841 tttacgctct cagcctttga tgagaatgag cagcctcttc cctacagcca tatgaaaaag 3198901 catttgttcc aatggcatga atcctcattt tacggaacct ttctagagga tgtcagcttc 3198961 atcgggacga ctgctgtcct tctatctcca tggatgactg tagagcttct cggcaaaaac 3199021 tcgttcaact cattcagctc cgtgcagctt acagaagaaa cggagccgct gatcgaggcg 3199081 gcatcgacca tctatgaatt tatcgcggac ggcgatttta tgcctgacta tgacgcatgg 3199141 acaaacggtg tttttcgctg gaaggaccgc gataatatac tggaaggctt tactgcggaa 3199201 tggttttccg ctgccgtaca ggattacatc cagtacgacg atgacctgcg ggagaaatgg 3199261 gaacatatca aggaaaaatc gcctgcggtt acgacattcc gtggccattt tcttgatgaa 3199321 gaggattttc tggaaggcat tggctggatt gacgatcaat ctccatttac tgtcggcttg 3199381 cgcttaaatg aaccggactt tgacggagac gaatggaaga tcgagatgtt tttacgcgat 3199441 aaaaagagcg gtgctgtaga attctttgac ggactgaaga gcctcaaaaa atcgtggcag 3199501 gcgtacagcg ataaaatcgc gcgtgagcag gaccgctttc acagaacggt tccgtggctg 3199561 tcgtttgatt ccgggacaac gctgatctcg gaggaagaag cctggatctt cctgtcagaa 3199621 gcaagtgaga cgcttgtcga tatgggggta gaaatcctcc tgccgtcctg gtggcagatt 3199681 gtcagagaca gcaacatgat gctgaaagca aaggtgtctt cctccccgcg cggcgagtca 3199741 tttgtcggca tgaatgcact gcttgatttc aactggcggt ttgcgacaaa tggaattgaa 3199801 ctgactgagg ctgaatttaa tgagcttgtc gccagcaaca ggcgccttgt taatatccgc 3199861 gggcaatggg ttaaaatcga tccgcagttt atcaaacaga tgaaacgcct gatggaaaaa 3199921 gcagaatcag agggactcca catgtctgat attctggcgc gggagctaat ggatcagcag 3199981 gatggcggac ttgaggattc ggacctgatt gatacatctg cttttgccgg cattcagttt 3200041 gatctgtcta aacagctcag gtcactgatt cgaaagctca ctgccgcgga aaacctgccg 3200101 gagcacaaag tcagtccttc tttcaaagga acgctccgcc cttatcagaa atacggcatg 3200161 aactggctgc tgtttctgcg ggaaagcggt tttggcgcct gtctggctga cgatatgggg 3200221 cttgggaaaa cgattcaaat gatcgcctat ttccttcacg tgaaggaaag cggccgacaa 3200281 aaaacgcctc atttgattat tgcgccgaca tccgtacttg gcaactggca gcgggagctt 3200341 caaacctttg cccctgatct gtctgtcgcg ctccattatg ggccgcgccg gccaaagggt 3200401 gatgatttcg ccgcgcatta tgaaaacgca gacgtggtgc tcacttcata cggtctgtca 3200461 catgccgata ctgaagagct ttcttctgtg acatggaaca cgatctgcct tgatgaagcg 3200521 caaaatatta aaaacgcgca tacgaagcaa tcacgcgcaa tcaggaagct gaaggggctt 3200581 caccatatcg cgctgagcgg cacgccgatg gaaaaccgac tgactgagct gtggtctatt 3200641 tttgacttca tgaataaagg ctacctcggc agtttgaccg gcttccataa acgctatgtg 3200701 ctgccgatcg aaaaagaccg ggacgaaaag agaatcggac agcttcagca attaatccgg 3200761 ccattccttc tccgccggac gaaacgggat gaagaggtcg cgcttaatct tcctgagaag 3200821 ctggaagaaa aagaatttat ccctctgtca gccgagcagg catcccttta tgagcagctc 3200881 gtcaaagaca cttttgacca tatgacatcc ctgaccggca tgcagcgaaa agcgctgatc 3200941 ctcagcatgc ttggacggct caagcaaata tgcgatcatc ccgcgcttta tttaaaggaa 3201001 gagcaaaccg agctgctggc cggcagatca gtcaagctcg aaaaattgct ggaactgatg 3201061 acagcgatcc gcgcccaaaa cgaaagctgc ctgattttca cgcaatacat tcagatgggg 3201121 aacatgatga agcggctgct tgaaaaaacg ttcggggaac ctgtgcaatt tttaaatggg 3201181 agtctctcca agcaagagcg ggatacactc gttgagaaat ttcaaaggaa agaatatccg 3201241 acactgattc tttcactcaa agctggaggc accggactta atttgaccgc cgccaatcac 3201301 gtcatccatt atgacagatg gtggaacccg gcggttgaaa atcaagcgac tgaccgtgca 3201361 taccgcatag gccaggagcg ctttgtccac gttcataaaa tgattacgac aggaacaatc 3201421 gaagaaaaaa ttgatgtcat gcttgaatcc aagcaaaccc tgaacgatca aattatccaa 3201481 agtgaaaact ggattaccga gctttccaca caggagctcg aagaattgtt tacattaagc 3201541 gctacagcgc aataatcatg actaaaaaag ctggctctaa aagagccagc ttttttccgt 3201601 tcatagccgt cacgccgaat ttccaaaaaa tccgttacgc cggttatcaa cagggtgcgc 3201661 ttttgtggca gcacatatac ttacaacaaa tgtttcatca tatgtgcgac accgtgttcg 3201721 tcattggtta aggtgacagc atcggctatc gatttgatgt cttcccgggc attgcccatc 3201781 gctacacctt ttcccgcagc ctccagcatc gatttgtcat ttaaactgtc acctacagca 3201841 gcagtttcct cgagcggaat attcagctgt tttgcaagcc tcttcagcgc ctgccccttg 3201901 gaagctttgc gggaagaaag ctcaaagttg tgctcagccg aactgacaag cgtcaaatct 3201961 tcggcatgct catatctttt ccagcctgcc tcaagctttt ctttgaagaa agaaaagccg 3202021 agaatattgt aaaaatcgat tggctcatcg gcttcaaaca gctcttgaaa ggagttaatg 3202081 taagcaaagc ccgattggct gtattgcacc tcggccgcct gcttaaggac agaaagatcc 3202141 gcttccggat ttgcgcttct gaatctgtcg agctcaacat caagaagttc tctgccgttt 3202201 tgcggcgtat aaatcgctga acctgtgaat acctcataat aatagttttc cgactcaagc 3202261 catgagagaa tgtcatacgc ccgtttctta tcaatcgttt cgtgatgata aagcctgccc 3202321 tcgggatcgt gaatgacggc gccgtttgca ctgatgaccc atgttttgat ccccagcggt 3202381 tcaaagattg acatgacgtc aaaatgagcg cgcccagttg acaccaccac ttcaatgccg 3202441 tcccgctgcg cctgccgcag tgcgttttca ttttccaagc ttacctgatg cttgctgttg 3202501 agtaaggttc catctaagtc aatcgcaatt aatttcacgt ttgtcagtcc tttccttcat 3202561 cctgctctgt cacgagaagc tcaacgccgt ttcggtcaag caagtcacaa aatgcctgat 3202621 tcggcagcct gtctgtaatc aagaggtcga tttcattcag ctccgcatac tgataaaaac 3202681 tggtgctgcc cagcttagaa tggtctgcaa gcgcaattac ctgctttgcc tgctgtatca 3202741 ttttccgctt caccatgcca tcctcttcat gcgcaattgt aatgccatgt tcggaaatgc 3202801 cgaccacacc aatcagcgct ttatcaacat ggtagcttga gagcttttca atcacagagg 3202861 acccgtacag aaagcggtgc tccttttcca gcttgcctcc cagcagataa atttcaattc 3202921 cctctttatc ggacagcaca tccgcaagat taatcgaatt ggtgattacg gtacaatcaa 3202981 ccgcattcaa atgctttgca catgcctgaa cagttgtaga ggcgtctaaa atcacccggt 3203041 ctccatcatg aataagcgat gctgcaagcc tgccgatctt atttttttcc tcagacactg 3203101 ttttcaggcg gccggaatag ctttgaattt tctgatgcac agtcggtaaa atggcgccgc 3203161 ctcttgtgcg gatgatggca ttctgttcct caagtttcac aagatctcgt cgcgctgtat 3203221 cccttgacac ttgcaggagc gtacagatct gctccgttgt aattcggtta tgctgtttta 3203281 aaaaatccaa aatcgctact aatctttctt cttggtacac gccctcattc cttttctcag 3203341 caatcattta taagtaatta taagttttta tttgatttta ttcaacatta ataagtgatt 3203401 ttaagtaaaa atgcgtcgag agaaccaatt tttcctaagt aggcaaaaag aaagaaccag 3203461 tctggtcgac tggtcaattt tgaggggatg atgcgaagat ccggataata gtgaatggat 3203521 agataacggg aggagcaggg gtgtcaatca gcagcttttt cccggggttt agggtccata 3203581 aaacgaacag tgtcagccaa cacttctgtt acatacacgt taacgccttc ctcgttttca 3203641 tagcttcttg tctgaatccg tccgcttacg ccgacgagag aacctttttg gcaatacaac 3203701 gccgtgtttt cagctgtttt tctccaaagt gtgcaattga cgtaatcagc ttcgatttca 3203761 cctgaagcat tcttgaagct gcggttcacc gcgagcgtaa catgtgcaac tgccgcaccg 3203821 gcggaagtgt agcgaagatc aggatctttt gtaagacgtc cgacaagcat gacctgattg 3203881 aacatgcgat tcctcctctc cttgcggttg tatgtattgt aaatgatgca acaagaaaag 3203941 aaaaacgctt aaaaatggct ttcagcctct gtttttatct ttcgttttca tttttccttc 3204001 agctaaaaac atcttttgct tttttccttt gaagaaatat gtacttttta aaaaacggaa 3204061 aaagatttgc tttgtcagcc agttttgcgt attcatgcgc acataggaag agccatccca 3204121 cgcaaaccac tgaaagctca attttttttc cggcattgac agcttgattt tatactgctc 3204181 catgccatct tgtgtttcgt ataaaaaact tattcttcct tttttgttca gatgaacctc 3204241 aaacacttct ttacggctta acatatatgt tacttccttt tgaatcaaat gactttcaga 3204301 aggaacgccg tcaatataaa tttcttttaa acgaaattga ttcataccac atctctccgt 3204361 aatccatagt cagttacagt ataatgaaaa aatagaaatt attaaatgtt tcgctcatac 3204421 aaaattcttt agccccaaca ttgcaggatt ttttcctcga aaacgtttat gttataatgg 3204481 aaggcaagaa aactttggaa gtaatcgggg tgagaagaaa tgaaaacctt taaactggtt 3204541 gacctgaatg tggaacgagt ggacaaggaa gaacaatcaa ttgaacagtt tccccttatt 3204601 gacggactga ttataaataa agaagacggt gaaaatcact ggctgattga ggcgcttgta 3204661 cagaaagaac atctgtcttt ttttgaacag cttcaaaaca gccaatctga agccaaagta 3204721 tttgtaacga tcacgaaaaa aagcaatcgc cccgcccagc tgacagcagc agtgaaaaat 3204781 atcgtcaagc tggaagaaag cattcaggtt ttactctacg gacaaatggt cacaagaaaa 3204841 cagcagggca ctgaaaccat tctcgagtcc cttgtaaaag agggctatac aggaacaaaa 3204901 ctcattgagg catttaagca aaaattataa atatgagggg gcatgttccc caaaacagac 3204961 tcagaaccga agagcatcac aatagacatt tagaatagat atgttctgca tgaaaaaagc 3205021 tgccgttttg aacggcagct tttctcttcg tgctttcact cttgcatatt taatttgtat 3205081 ggccaaaaga atcaaccaat tcccctttca caacgaggcg cccttcggtt ttgaccgcct 3205141 tgtcacatgt gattaacgta atctcctttt tgtttgtctc ctcaactaca tctgcatcca 3205201 tttccgatat gatgtctttc gatgttacag aatagatata atccttttta aaatccgtga 3205261 tgacaatttg ggcacctgtt tttatgtttt ccagaggtcc gaacagaaga ttcttttgct 3205321 tcaaatgatg gcccgccaac ggataatttc cctcacccat tttttgatcc cggcgcattg 3205381 ttgccgcccc tatcaaaaga ttttcattgg ttgtgccttt tacgatcgga agctccagat 3205441 cgacactttt aattgttatc cgccgccttg attgtgaagt aaaaataagt atatttcacg 3205501 tgctttcgac gttctccact tgactggaat gctttaatgg cgatcccggc atctgtagct 3205561 tcaggctttc cttcagagga atcagaaatc tcaaactcta ttttctcagt gttcagcaca 3205621 taaccggctg gcgctttcgt ttcaacaaaa gcgtattgtc ccggtgcaag gcctgaagct 3205681 gtgacttgat gatgccggat atgactggtt tcgaagtctg tatgaaaatt cgcgaacgat 3205741 tcagcatggt tgatcttccg gttctgatca ttacagctgc cattatcggc catgacaaat 3205801 acaaggcttt tcatgccgga gcgaatgaca ttttgcaaaa accctatcat tactctgaat 3205861 ttatggcgcg tattcaaaac ctgataatga tgaaacatac agcaaatcaa gccacaagaa 3205921 tggaaatggc gtttctccag tcgcaaatca agcctcattt tctttataat gtattaaaca 3205981 cgattatttc tctcactcat ttggatattg aaaaggcccg ggaggtaaca gaggaattta 3206041 ccaactattt aagaatgagt tttgactttc aaaatacatc agccatcagt tccttcagac 3206101 atgagctttc gattatcaat tcctatcttt ctatagaaaa gacgcgattc agtaatcggc 3206161 ttgaggttct tttcgatata gatgaagaca ttgactttat ccttccgcct ttaatgattc 3206221 agcccttggt ggaaaatgcc gttcttcacg gtgtcagcaa gaaaagaggc ggaggatgga 3206281 tcaaactgac agctaaaaaa caaagcaaaa atgagtatca catcaaagta gaggataacg 3206341 gtcccgggat aactccggaa aaacaaatag atctcttatc aacggatttt gatcgcagcg 3206401 tcggattgaa aaatatcaat cagcggctga aacatttttg cggaagcgag ttgatgatca 3206461 gcagcactcc ggatgcaggc acctctgtct caatgctcat tcatctcgct gaaacaacag 3206521 gaagccctaa agaactgaag gacacagaac gaacctaaac gaaaattgag ataaaaaaag 3206581 acgccgtttc taacggcatc ttttttattc cggcgacttt gcttgctgct tcagcaggtc 3206641 tctgatttct ttcagcagct cctcctgcgc atccaccgct tcctccgcag cctcttcttc 3206701 tgcttctttt ttgcgcctta acccattcaa agtccgaatg acgataaaaa tggagaacga 3206761 tataattaag aagttcacaa tcgtctgtat aaagctgcca tatttcacta cagcatcgcc 3206821 aaacgtaaac gacaggcctg aaaagtcaag ccctcccagc agcaaaccga ccaaaggcat 3206881 aatgatatca tttactagag atgtgacgat ctttccgaaa gcgccgccta tcacaacacc 3206941 aatcgcaagg tctacgatat tcccccgcat ggcaaaggct ttaaattcat tccacataca 3207001 atcacctgct tttctatatt tgtaaagaaa aaaagacaaa tgtgccgctg gccatctgcc 3207061 ttttttcaat tattctccga gggcaaaagt cagttctact tcgcaaacga cttcgccatc 3207121 aactgtggca acgccttttc cgcgcccgat tgtgccgcgg gcacgaatga tttcaacctc 3207181 aaggtgaagc tggtcaccag gcttgacttg ttttttaaag cggcagttat caatgcctgc 3207241 aaaaaaagcc agtctgccgc ggttttcttc tttaatcaac atcgcaacag ctccgacttg 3207301 agcgagtgct tctacgatta atacgccggg cataaccggg tactgaggaa aatgtccgtt 3207361 aaagaactct tcattagcgg ttacattttt atagcctttt gcccgtttgc cctcttcaac 3207421 ttccgtaatc cgatccacaa gcaaaaacgg ataacggtga ggaataattt ctttaatttg 3207481 ctgagtatca agcattgtct tgacatctcc ttcatctgca ttagtatgta tagcaatcat 3207541 caaagatcca atctgtacat ttgaaaagta tattatgaat taatctcttt ttcaaccgcg 3207601 ctaaaatgta accaactgtc aatgagagcc gtcaaaagtt atgatatgat aattatagat 3207661 tttaccaata gcaaagaggt aggaaaatga tttcgaagtt tattgaaaaa agaatgctaa 3207721 acatgttaga cgagtggtat tccgcaatga gcaaacgcaa aatgaatcac gtttgcacac 3207781 tgaaagagaa aattgatcag caccttccaa agatcaaaaa gaacacaaaa ctttggatgc 3207841 gttatcaatt gtttcaggcc cgccatcagc tgctttttga aaaccagaac ggactcgatt 3207901 cattgttcga tggcctatat ggcctggaag acaaaatgga tgatgaattg aaatattatc 3207961 tgtatttttt ctctgggtta tatgagatgg taaaaacagc tccgaaacat gcagtacatc 3208021 attttaaaaa agctgaacag tacctggccg ccattcacaa tacgtttgaa gccgctgatt 3208081 tatattatca aaccgccggc gcctattact tgatgaaatc accgccgctt tccgtccaat 3208141 acgtcaaaaa agcattacac atctatttgc accaattcgg ctatatcaaa aaggtaatca 3208201 cctgtaaact tttgctcgcc gtgaattata ttgatcaaga acgctatgaa aaagctgaac 3208261 agcttttcaa agaaatcatt aagaaaaccc agcaactaca tgacgaaaac ctgctatgcc 3208321 acgcttatta taaccttggc tttttaaaag cgaccgagaa aaaagaccag gaagcgcttc 3208381 tttactttag aaaagtatta aagaatcaag aatttgaaat gaattcacca gtctcatatc 3208441 ttcattgtgt gtacgagtct gtcagagcgc tttttaaaac agggaacatc acagaagcta 3208501 aagccgtcct tcaaaaagga aaagaattat ctgaaaaggt agacattcaa accatttatt 3208561 taaaattaaa aacgcttgaa gccctctaca catcagccga agacccttat gagcagctgc 3208621 tcgaatatgt gcttgaatta gaaaaaatcg aggcgtgggt ggatttagaa gtgctgttag 3208681 aagatattac ggaatactac aaaaaaaagg acgatttcga aaaagccgct ttttttatca 3208741 tgcgcggctg attgaaaaac gcccattttc ttattatctg actgaattga ttaaaccgag 3208801 catttgatct cccattgtga tcgttctgct gttcagctga tatgaacgct gggacgtgat 3208861 caaatctgtc atttgttctg aaatatcgac attggacatc tcaagtgagc cctgctgcat 3208921 gccgatgttt tgtctattag cgccgttcag ctcttcaaaa gctgccgcat tatcaataga 3208981 gaaaaggtta ttcccttcgg atttcagctc ttgagggtta ttcacttgga caacgccaag 3209041 attaaaccgc tgaaccgcgt ttccgtcaga tgcggttaag gtgccgttct tattaatggt 3209101 gatattcttc attgagctgt cgatgttcac tgtattgccg ttctcatcaa gtacgggata 3209161 cccatttcca gtgacgagct gcagctggtt ggcattcgca gcggacggcg ttacatacag 3209221 cgccccgtcc ctcgtatact ggcggtttcc atttacattt acctgaagat actggtatgg 3209281 agacgtaaat gcgatatcca gatcgcgatc ggtcttctga atgcttcctt gatcagagac 3209341 taggcgtgaa ctcatcatcg ctccgacgcc aaggcgcaag ccgggcggcg tttttcgggc 3209401 ttttgccact tcctcgtttt tttcatcaac ctgatcgaat tgctgtctga caagctcaga 3209461 aaaattcgta tcttttgcct tatagccggt tgtgttgctg tttgaaaggt tgctgctgat 3209521 tgtgtcaatc tgctgctgca gctggtttaa ggttgttgat gccgttagca ttgacctgag 3209581 catagttgat gtcccccgtt tttttcttcc gttttcttaa atttttccaa tttcatttgc 3209641 tgctttatcc atacttttat cgtaagcctg aataaccttc tgattcgcct caaacgatct 3209701 gtacgcttca gtcatttctg tataggcgct tgtcacatcc acgtttgaaa gctctgagac 3209761 gccttgtttt aatgaatagg ctacctgatt atttccggct gcgcttggca gatcattacc 3209821 gtccgccgtg ctgtacaaat catttccgtc ccgtttgaga ttgcggacat cttccgccat 3209881 tctgacatca atctggccgg ctgtgcgtcc gttcgttgtc acagtaccgt tttcagacac 3209941 agtgaaattc tcattatcaa cagtgattgg ctggcgatcc gtcgataaaa tagggcgtcc 3210001 gttgatcgtc agctgattgt tctcatttag tgaaaatgtg ctgctttttg aataacggat 3210061 tccatccgct gtttgaaccg gataaaaaag agcagctttt tcattggttt ccgcactcat 3210121 cggaacttga ttttcgatca atgcaatgtc tgtaggctgg tctgtggact tcaggcttcc 3210181 ctgtgtaaag agaggcttga gctcctgcat atatactccg gtattcacgg aaccgatttc 3210241 cgtccttgat gtcccggccg gagattttga ttctattctg ctgagcagca tctcagggaa 3210301 cgcgcgcata gagccttgat cagctttata tcctgatgta tttgcgttag caatattatt 3210361 tgaaagcatt tccgttcttc gctgctgggc aatcattgcg gatgttgctg tatataatcc 3210421 ttttaacaaa tttcccacct ctaaaaatgg cattttttcc agttgtcata taggaacgtt 3210481 cgttctataa taaaaactca gtattttatc ctattatcgt catttaacat cttttcgtga 3210541 aggctttttc ataaaaaaac ctcattcttt ttcagaatga ggtttgtgaa atcagcttag 3210601 tttgcgttta ggaagcttgt ccatattatc aagcatgaca cctgtgccga tggctacgca 3210661 atccatagga ttttcagcaa cgaggaccgg taccttcagc tcttcagcaa gcagctggtc 3210721 aaggccgttt aagagcgcgc ctccgccggt aataataacg ccgcggtcaa taatatcagc 3210781 agaaagttca ggcggtgttc tttcgagcac ttgttttgca gcctgaacaa taacagcgac 3210841 agattcacga agggcttctt caacttcttt actgtttact gtaattgttc ttggaagacc 3210901 ggaaaccatg tcccgtccgc gaatggaaat ttcctcgtga cgtgcgtctg ggaaaacagt 3210961 tgcgacttta atcttaatat cctccgcagt acgttcgccg atcagcagct tgtactcgcg 3211021 tttgatataa tttaagattt ccatgtcaaa cttgtcccca gccattttaa tagaagagga 3211081 ggtgacaata tcgcccattg aaataaccgc gatatccgtc gtcccgcctc cgatgtctac 3211141 aaccatgtta ccgcttggct ggaatatttc catacccgcg ccgatagcgg caactttagg 3211201 ttcttcttca aggtacacat gtttcccgcc gcttttttct gcagcttctt taattgcttt 3211261 ttgctcaacg gatgtaatat tcgtcgggca gcaaatgagc atgcgcggct ttgagaacag 3211321 gccttttaca ttcagcttgt taataaaatg tttcagcatt gcttctgtta cttcaaagtc 3211381 agcaataact ccgtctttca gcgggcgaat cgcaacaata ttcccaggtg tacgtccaac 3211441 cattcgtctt gcctcttcgc caaccgccag cactttgccg ctgtttttat caagtgcaac 3211501 aacggaaggt tcattcagaa caattccttt acctttaaca tggatcagta catttgcagt 3211561 accgaggtca ataccaatat cccttgcaaa catctattta tatcctcctt gaaaatctgt 3211621 ttcacagtaa atatccacat tgtgccctaa ttatatatat tatcataaaa tatagaaaaa 3211681 aagttggaag cacaataagt tctttacaaa tttttgcgga tgttttatga acgatttcaa 3211741 gaaggcaatg ccaggtgatt acgattgctg aacaggctct ccttcgagaa tttcatcttt 3211801 tttatatttg agctttgtcg cttctcctcc tcttaaatgc ctgatggatt tatgataatc 3211861 gagtatttct ttcacttcgt ttgccaagtc ggggttaatt tcaggcagac gctctgttaa 3211921 atccttgtgt actgtacttt tggaaacacc aaattccttc gcaatgacac gaacggtttt 3211981 ctttgtctcc acgatgtact tccctatctt gattgttcgc tctttgatgt aatcgtgcac 3212041 accactcgac ctccctaaaa tggatgtgag aagtgtgaaa tgagatccgt attctgtaaa 3212101 gagtcgttca ttatgccgct tcttcgttgt atggttttaa aagtaagttt gtgaaatatg 3212161 cccacgatcc ctcacctcaa acactctctt tgttaggttt gtaacagtgt attagcattc 3212221 ttttgggaat atgctaaaaa ctcaataagg acaaggggtg aaacgaactt tttcagattc 3212281 agcaaactat ttcgcgtcac taaattttca tctttacaac tattgatcgc tcctgtaaaa 3212341 tgaaataagc aattagttac ttaggtaagt tttttagaag gagaccgaca tgtcctacgt 3212401 caacagacac ctcattcatc aaatcaacca aagcgcccgc ctgattgcca agaaagccaa 3212461 tgaacagcta gagccattcg gcctttattc atctcaatgg tcagttttat attgtttgcg 3212521 tacgatcgga ccaatgactc aaaaagagat ttggtcctat ttaaatgtgg aagcgccgac 3212581 tgtgactcgg acgatcaaac gcctggagga gaacggctgg gttcagagac ggcaaggtga 3212641 agacaaacgg gaaaaacttg ttgtcctcac aaaagaagcc gagaaaaaat acgaagaaat 3212701 caatgtgaaa atgttgaaat tcgaggaaga gctgcttgca gatttccggg atgaagataa 3212761 agaagctttt tctcatttat tccgcatgtt tttacaacaa tgaaaataag gaagtgacat 3212821 acatttgaaa aaagcggatg cgatatggac caaggatttt attatggtcc tgcttgtcaa 3212881 tttatttgtg tttgtgttct tttatacatt tttaactgta ttgccgatct atacactgca 3212941 agagcttggc ggcacagaat cacaaggcgg gcttttaatc agcctgttcc ttctgtctgc 3213001 gatcattaca cggcctttct ccggagccat cgttgagcgt ttcgggaaga aaagaatggc 3213061 gattgtatca atggcgctct tcgccctatc atcttttctg tatatgccga ttcataactt 3213121 ttccctgctg ctcggattgc ggttcttcca agggatttgg ttcagcattt taacgactgt 3213181 tacaggtgca attgccgctg atattattcc agccaaacgg cgcggtgaag ggcttggata 3213241 ctttgccatg tctatgaacc tcgctatggc gatcgggcct ttccttggcc tgaatttgat 3213301 gagagtggta agctttcctg tattctttac agcctttgcg ctgtttatgg ttgcgggctt 3213361 acttgtttcg ttcttgataa aagtgccgca aagtaaggac agcggcacga ctgtattccg 3213421 ttttgcgttc tcggatatgt ttgaaaaggg cgcactcaaa attgcgacgg tcggtttgtt 3213481 tatttctttc tgttattcaa cagtcacatc atatctgtct gtattcgcca aatcagttga 3213541 cctttcggat atcagcggat atttctttgt ttgttttgcg gtgacaatga tgattgcacg 3213601 cccgttcaca gggaaattgt tcgacaaagt cggaccgggc attgtcattt atccatcaat 3213661 cctgattttc tctgtcggac tctgcatgct gtccttcaca catagcggct taatgcttct 3213721 gctttcaggg gcggttatcg gtcttggcta cggatcaatc gttccttgca tgcaaacatt 3213781 ggcgattcag aaatctccgg ctcaccgctc cggttttgcg acggcaacgt tctttacctt 3213841 ctttgacagc ggaattgctg taggatcgta tgtattcgga ttgtttgtag catctgccgg 3213901 cttctctgcc atttatttaa cagcggggct gttcgtttta attgctctgc ttctctacac 3213961 gtggagccag aaaaaacctg cagaggctga aggaaaagtg tctattgcag aataacttgt 3214021 cagactgccg ggaaatcccg gcagtctttt ttccattaaa acacggcgcc ctctcggttg 3214081 aacgagagaa cgccgcttat agcaattatt caatgacagg ccgcgcaggt gaatcaggat 3214141 ctaacgaaaa atcataggac gcttcatcac gaaacatcgg atcggcatat atggattgtt 3214201 gatcgttttt tgttgctttt cgatacgaag aaaatgaatc atattctttc tttttccaca 3214261 tccatatgcc gtcttgatcc gcttccttgt ggtacacgtt atgattgacc gtattacctt 3214321 cgttttctgt aaagtcgttt ccgataaata atctggaatc accggccgtc aatatattct 3214381 tttcaattgt gttgtttttc gtatcgtact gcagcagcag ctgtccgccg tacagtccct 3214441 ttgtgtcatt ccggtacata atattgcggg caatcagaga attgctggtg ccgccccgct 3214501 ttttgtcata tcctccgatt gaaataccgg tgtacgcatt gttgtacact ttgttgtctg 3214561 tgatctgaat ggcatttgca tactttcctt tgtgttcaga cgttgcttca atcccaatat 3214621 cgttatcgta aactgtgttg ttcttaattt cgatatcgtg tcctccatcg acataaatcc 3214681 cgcccgctga gtattcatct ccataagcag gattgccgta agtcgagttt tgataaactg 3214741 tattgttttc tacgactccg tttcgcacgt aatcgttttt atccgcggtt ccctcataac 3214801 caattagatc aatcccgatg ttattattgt tgcggaccac attgcctgca actgtgaagc 3214861 cgtcgatatt accgttcagc acaactgctt cactcgctcc aagcgtcagt ttctcaactg 3214921 tattgtcctc gattcggatg tctttcatgc tgccagtccc ataaactgcg attccgtgag 3214981 catttccttc atccgctgtt gtcttaatcc cccggatgtg attatcctta atggcgatat 3215041 gactgctgga ccctgataca taaatcccta tagcagttgc ttcctcagat gaaacagaaa 3215101 gatcttgaat tgttaaaccg ctgatggcaa tgtcatgttt atcgtgaata cgaataagcg 3215161 gtgtttcata ttcagcgttc gcaacggatt caccgctaat cacgacgttt tcattttcat 3215221 agtttcggaa tgtgataggc tttccgtccg taccgctgtg ctttacatca agggtctcat 3215281 gatacgtgcc ctcccgaatc atgacagttg tgccggcagc agccttctca gatgcgtgtg 3215341 ccaatgtacg aaacggcttt tcttttgttc cttcattttg atcactgcca tttggcgaaa 3215401 catacagata atccccagat ccttcctcat tcgcttttgt cttatcataa acgaaagcga 3215461 ggatgacaga cgttaaaaca cccgccaaaa gaataaaata ccattttctc attttcgatt 3215521 cccatttcgt tttagaatag atttctaaaa ccattataaa tgttctattt atggaaaacc 3215581 atttcaaaaa tatgaaaata taccgtctaa atagatctta ttcagcctgg cggacctgcg 3215641 catgttcaac tgtttcaatt gccaatgatg caggcgggtg aacacgcatc agaacaatgt 3215701 agaaaagaaa ggaaatcagc acacctacaa accaagaaat atcgtataag ctcttcaata 3215761 caggaacata catgccaatc agcgaaatca gcgctcctaa cattgtggct gcaaacgcac 3215821 ggtaattgta gcccttccaa tacacatacc gtcctgtttc ggaatacagg tcatctaccg 3215881 agagctcacg tttgcgaatg ataaaatagt cggccatcat cacgcctgcc accggtccaa 3215941 gcatgccgcc tattaagcca agaaacgcat acacgcttgt cgcgctctcc atcagcttcc 3216001 acggaaccgt aaataaagcg agcaacgctg tgataaagct gccacgtttg aaattgatat 3216061 atttcggcag ggcattcgct atatcataag cgggtgatac gatattcgcc gcgacattta 3216121 cagagatcgt ggcgatgcag agtgtgatca cggacaagac gatgacataa gggttatcaa 3216181 accgcgccaa aatatcgaca acatcccaaa tcggctctcc gaacgcgacc tgcgagccgg 3216241 aggtcaccgt aatacttgcg aatgcgaaca gcgcaaacgt tcccggcaaa ccgtaaaatt 3216301 gtcctttgat ttgctctttt tgtgtttcag caaaccgtgt aaaatcaggt atatttaaga 3216361 tcaatgtcgc ccagatgccg atgatgccag taactccggc agcaaacggc cagaatgttt 3216421 ctgaaaacgt atgaaacttt cctggttgag agtatatcgg gcccaatcct ccagcaatat 3216481 caacggccca ccataccatg ccgccaaata ccagatacac taaaggccct gcccacacct 3216541 caaaacgttt aatcgactcc atgccgtgat gcaatacgag taaatgaatg gcccaaaaga 3216601 atacaaagga aagcaaaccg gacaagtgaa tgccgagaat gttccactcg ccgccaattt 3216661 ctccccaacc tggccacata ttcaaaagca aaatgttcag tgccgtgcta cccgcaaagg 3216721 tctggatgcc aagccacatg atagctgtaa acgcccttag aagcgcgggg atattcgcgc 3216781 cgtatatccc gtaagaagcc cgaatgatca ctggaaacgg cagcccgtat tttgtccccg 3216841 catggccgtt taaggcaaga gcgccaaata ggataagtga tgccgtaata atgatcgcca 3216901 gcacctgcca aggcgaaagg ccgatcgcaa ttaatcctcc cacggtcgcg taggtcggta 3216961 tgttatgtat acatcccatc caaatggagg caaagttcat tgctttccac gtccgttttt 3217021 cctgtcccaa aggcaccaga tcttcattgc tcagcctgtt ggattgctgc tgactctctt 3217081 ttaatttcat agccggctcc cctttccata ttgtctatat gtcgtcacac gttatgtttt 3217141 ttgacattag atgtcactta atataactga agagtcagac aataacactg gctatgatat 3217201 acaattttcc cgtttgtatt tgaacagctt aaacaagaaa aagagacaga cctcagagcc 3217261 cgtctctttc ttaagatgca gttttcatta atgcagcaaa tctcacagcc attaacaggc 3217321 ttgctccgcc cgctataatc ataatgattc ccatcatatc aaaatgggct gccgtgattt 3217381 ctttaccaaa aagaatgcca aggatcaccg aagacaaaat cgatcctagg taacggcagg 3217441 tttgaaacag gcctgaagtc gttcctacca tgttggaagg actcgtttcc agcatcgctg 3217501 cctgaagcgc gacattgccc agtccgtagc ctatacccaa gagcgacaga atgaggcctt 3217561 taccgatggt ctggacattg ataaaaaaga tggttaagag cacggctcca gccgtcatca 3217621 aaagcgctcc cgcaaagatc ggcttgacga caccagatcg gtcgatccat ttgccggtta 3217681 gaggtgacac aacgatgctc attccagaca taaacagcat aaacaggccg ctcgtttgaa 3217741 cagaaagatg catttcatcc tgaaagtaac ttggcaaacc aaaaaataaa caatagaaga 3217801 aaacattcaa taaaataaac tgaacataca cggctgacag gtttcgctgt gttttaaaca 3217861 gacggacatc aataaacggc ttatccgttt tcagctcgcg ccagacaaac gcacagagca 3217921 gaagcaagcc aagcacacct tcaaccgcat gcggcgacgt gctgaacgac agcaaaaagg 3217981 atagaaggaa aatgattccc ccggcaaata aaacaattcc aagaatatcg agctgccgaa 3218041 taatggtttt gattcctgcc ccttttttct gatctttcgg gaacatatac aggcccaata 3218101 agaagctgag gataataaac ggcaaattaa cgataaagat cgccggccag cctccccata 3218161 caatcaaaaa cccgccggct gtcggcccca gcgccgtcat ggcggacgca aaaatagaga 3218221 gtacagccaa ggctgaagct tggcgctcat gaatatgatt ccgaatcaag ccgacacctg 3218281 acggataaat cgcactgctc cccaccgatt gaaacagccg catgaccaat aatgtcataa 3218341 acgtcggcgc aaacggcgcc ccgatggcag aaaccgcaac aagaataagc ccgaataaaa 3218401 acaagcgttt ccgcccaatc aaatcaccga gctttcccgt tacgggctgc gctacggcac 3218461 tcgccaagta aaacgaggaa atcagccagg aaaccgttgt aaacgagagg tgaaactcat 3218521 gctggatgct atggagcgca agagagatca tagacgagtt cagcggattc agcattgttc 3218581 ccgaagccac agctgttaaa aaaacagctc ggcttttttt cgataacatc atttcacttg 3218641 ttccagaaac tcttccgttg tccgcgattt accgattctc gggaaaataa agcgcagtgt 3218701 ggcttcatgc tcttcatcgc taaatgtgga catggcatct gtaataaaaa tctgctgata 3218761 gccaagctga aatgcctccc gtgctgtgct ttccaccccg atattcgttg cgatgccgca 3218821 caatacaatc gtatcaatgc cgcgacgtct cagctgcaag tctaaatctg tgccaaaaaa 3218881 agcaccccat tgccgttttg tcacagtata atcgccatcc tgcacaccga tttccggaac 3218941 aaattcggcc cagtccgccg gcatttcccc tgaacctccc tgcgcaggct catccgtttg 3219001 cggcttcagg gcgtccgctc catcatgaaa ggctacattt acaaagctga tgaacccgtt 3219061 atgtttccga aattcatcta cgagcttttt cgcgttcggg acaacctggc cgctttgatc 3219121 aatcggcaca attccctttt gtaaatcaat gataaccaat gctgtttttt gaaaatcaat 3219181 gttgagtgta ttcatcatac gtctcctcct gatactgtta gtgtttctca cattgcatat 3219241 tttactcttc acactgccta agttctttta tgatgcttgt gaaattctca gaaggagcgt 3219301 tttctcatga tttttctttt atgtagtagt aacaggttgt gcatacgaac aaaccggcaa 3219361 gcactgtaat cataaagggc gtcatcgctt catcacctgc ctgctgtcta tcggttcctg 3219421 cctgaaaatg cccatgaatt tgcggcggtc catccaaagc aggataagac acataaccat 3219481 taatatcgtg ctaagatcct gcacgccaat atcaaaacaa tagttaatca agacgatgtt 3219541 cacaataatg ggcataaaaa taaccgcccc taatgcagcc gttcgcggaa tcagtaataa 3219601 aacagctgcc aggatttcac caaaacctat aaacagttca tagacatgag aataaccgaa 3219661 aaatgtccac gcgatcgtaa accccttccc ggcagccgcc tcgatttcag gcgtcacctc 3219721 gccaaactgg ccaattacca ctttcgccag accgtacacg aaaaaattaa aggctaaaaa 3219781 caatcggaac gtcgcgggaa tcgacttgcg taccgctttc ctcagcctgc cgcctttatt 3219841 catcatacat ccccctcagt gtattatttg atgtagtaca cttaatacag tatagagtat 3219901 tctaattaat gtcaattccc ttttcagctc atatgaatag tttcttttat agatacaaag 3219961 tcttatatcg caaaaaatgc cattctcctt cctttccatc cctcgataac atttctcaaa 3220021 aaccatgtca ggaaatctta catgaaaatg ttttatcatt cttttttctc tataatgaag 3220081 aaatataata attgcttttt attctgaaag atacggagga atgagacatg caaatgggcg 3220141 atacagtttt tatgttcttt tgcgctttac tcgtgtggct gatgaccccg ggattagcgt 3220201 tattttatgg aggaatggta aagagcaaaa atgtgctgag cactgccatg cacagtttct 3220261 cttccattgc catcgtttcc atcgtttggg tgctgttcgg atatacactt gccttcgcac 3220321 caggcaattc aatcatcggc gggctggagt gggcaggcct caaaggggtc ggatttgatc 3220381 cgggagatta cagcgatacc atcccccact cgttatttat gatgttccaa atgacgttcg 3220441 ccgttctgac tacagcgatt atttccgggg ctttcgcaga gcggatgcga ttcggcgctt 3220501 ttcttttatt ctcggtttta tgggcctctt tggtttacac acccgtagcg cactgggtat 3220561 ggggcggcgg ctggatcggc cagcttggag cgctcgattt cgctggcggc aatgttgttc 3220621 atatttcctc cggggtggca ggacttgttc ttgccattgt gctcggcaaa cggaaagacg 3220681 gtacagcgtc ttctccgcat aacctcattt acaccttctt aggaggagct ttgatttggt 3220741 tcggctggtt cggctttaac gtcggcagcg cattgacctt agatggtgtg gccatgtacg 3220801 cgttcatcaa cacaaacacc gcggctgcag ccgggatcgc cggctggatc ttagtagaat 3220861 ggatcattaa caaaaaaccg acaatgctcg gagcggtatc tggggcaatc gccgggcttg 3220921 tcgccattac gccggctgcc ggatttgtca caccgttcgc ttccattatt atcggcatca 3220981 tcggcggagc tgtttgtttc tggggagtat tctcgcttaa aaagaaattc ggatacgacg 3221041 acgcgcttga cgcctttggc ctgcacggga tcggcggcac atggggcgga atcgcaacag 3221101 gattattcgc aacaacctct gttaactcag cgggcgcaga tgggttattt tacggtgatg 3221161 caagcttaat ctggaaacaa atcgtcgcca tcgccgccac ttatgttttt gtatttattg 3221221 tcactttcgt tattattaaa attgtaagcc tcttccttcc ccttcgcgca actgaagaag 3221281 aagagtcact tgggcttgac ttaacgatgc acggggaaaa agcatatcaa gattctatgt 3221341 gaggagtgac gctatgagcg gtcaaatgtt caaggtagaa attgtaacgc gtccggcaaa 3221401 ttttgaaaag ctgaagcagg aactcggaaa aatcggagtg acctctctga ctttctccaa 3221461 tgtacacggc tgcggccttc aaaaagcaca tacggagctc tatcgagggg taaaaataga 3221521 aagcaatgta tacgagcgtt taaaaataga aattgtggtc agcaaggttc ctgttgatca 3221581 agtgacagag accgctaaaa gggtgctgaa aacgggatca ccaggtgacg gtaaaatatt 3221641 tgtctatgaa atcagcaata cgatcaacat ccgcacaggc gaagaaggac ctgaagcact 3221701 ttaatatcgg tacgagattc ggacactccg gatctctttt tttgtgcaca gaatcccccc 3221761 agaaaccgcg attcctcttc gaattctctt caagcgccgt tatttcagac aatctctatt 3221821 tttatttgaa acttttcatg agtaagatta gtctactaaa tataaaaatg taaaaggtga 3221881 ttatttgaac tacgaaattt ttaaagcaat ccatggacta tctcatcaca attcagttct 3221941 cgattccatt atggtcttca tcacggaata tgccattgtc gcctatgccc ttatcctatt 3222001 ggcaatctgg ctgtttggga acacacaaag cagaaaacat gtgctatacg caggcatcac 3222061 aggaattgca ggccttgtga tcaactattt gattacgctt gtttatttcg aaccgcgccc 3222121 gttcgttgcg catacagtgc atacactgat tccgcatgct gcggatgctt catttccaag 3222181 tgaccatacg acaggtgcat tagcgatttc tattgcgatg cttttcagaa accgcaaaat 3222241 cggctggccg cttgtcattt ttgggctttt gacaggcttt tcgagaattt gggtgggaca 3222301 tcactatccg gtagatgtat tgggcagcct cgttgtcgcc atcattatcg ggttcctttt 3222361 ctttagattt tcagatctgc ttcgcccgtt cgtcgatttg gtcgtgagga tctacgaagc 3222421 cattatcaat aaactgacga aaaaaccaac cgatcaaaat ttctaagaaa gacaaaagcc 3222481 ggcgtctgaa atcaagacag ccggctttaa tatttctcat acatctcttg ttttcttcgc 3222541 ttcgccaaca catataaacc ataaaacaac ccaattccaa cagcatcgat gagcacatcc 3222601 cggatacaac cattcctgct gaagaagagc tgaagaactt ctgtgaaaaa agcaaacgca 3222661 aatgagccgg ctgcagctga tcttatgctg ccccgctgtt tccacagcaa atatgtcagc 3222721 acaaagaagg aaaacgcgtg tccgattttt tgaataaacg cttcaggtac agtaagctca 3222781 gtaaaatcca taactaaaaa ttgagacaga tcagggtgcg gctgaaaatg aaaagccacc 3222841 gtttgcgata cgaccatgcc gctgaagctt tccgtacaga cagaaagcag gataaaaaag 3222901 atccagcctg cgagcaatag gcggttcatg acataacctc ctttataacg tacgtgccta 3222961 catgtaacta catagacggt aaaacaaagc aaaaagtaac agaaaaaaac gcccatcaca 3223021 aggatagacg ttttcttcat taagactgtt cagtgtcttc tgttgtgctg ctttctttag 3223081 aaccagattt gtcagttgaa tcatcctttt tctcaccgga tttttcttct gttccttttt 3223141 cagttgatcc gtcctttttc tcggaagatt gctgaatgga ttcttctgtt tcttgggtgg 3223201 cagctttttc aatagaagaa actggtttgt ccataaagtt taacggattc attgcaaccc 3223261 catctttacg gatttcaaag tgcacgtggt ttccgctgtc ttcactgtaa aggttcttgc 3223321 cagattttcc gatcacttga ttttgtttta ctttgtcacc ttgctctacg cttacttcgg 3223381 aaagagattg atacacagtc gataaaccgt cggcatgttc tacttccaca acatatccca 3223441 gcactggatc tttttcagct ttaacaaccg taccgctcag agaagcagag acatcgaaat 3223501 cttttccgtc tttctcagct aagtcaattc ctttgcttag gctgtacgtg ttattatagg 3223561 taacgagtgc tgcttctttc tcttcttttg cggcatcggt ttcatagaac tttttcacaa 3223621 cagaaacgtt ttcagaatca acaaccggca ttgcgacatt ttccattgac tttcctactt 3223681 caactgcatc gtcgttgttg tcatatgcgg agtttccgcc gttatcagcc aactgatcct 3223741 ttacctcatc atttgatact gattgatacc aaaggacagc tgttaaaatg acggccgcac 3223801 tgactaagta aattgcaggg aacacccagc gtttacgaaa aaactgctga agttttttga 3223861 cttgagaagt tttcttttct tcctctctca ttgtttcatc acctcagcaa cattctgaac 3223921 acttttctga aaatatatac aacctatcca aaaaaacttt tttagatgta gtttgcacag 3223981 actgaacgaa aatatgtatt tttttgagag gagtgccaaa aacgtatgaa catgacattg 3224041 cgtcttgctg aacatagaga cttggaggct gttgtggcga tttataattc aacgattgct 3224101 tctcgaatgg taacagccga taccgaaccg gtaactcctg aagaccggat ggaatggttt 3224161 tcgggacata cagagtcacg tccgctctat gtggccgagg atgaaaacgg aaacgtcgct 3224221 gcctggatca gctttgaaac attttatgga aggccagcct ataataaaac agcggaagtc 3224281 agcatataca ttgacgaagc atgccgcggc aaaggtgttg gatcatattt gcttcaagaa 3224341 gcgctccgca ttgccccgaa tcttggcatc cgctcactta tggccttcat tttcgggcat 3224401 aataaaccaa gcctgaagct gtttgaaaag cacgggtttg cagaatgggg actattcccc 3224461 ggcatcgccg aaatggacgg gaaaagatac gatttaaaaa ttttagggag agagctttca 3224521 tgattagtct ggataaagat gaaaacgaaa ttgaacatca taatgaagaa aatagccttg 3224581 ttgaacagga gactgcacct gttggacagg agagccgcca gctgagcgcc tccgctgtca 3224641 agtcgctatc cgacattgcc aagtggggca aaatttctgg catcttgtta atcattatgg 3224701 gatcgcttgt cactctgtct gttttgatga cagtgattgg cgccatcccg ggcgtactgc 3224761 tcattatttc aggcgtattt ttgatgcgct cagcaaaagc agccgcggaa gccgaaggaa 3224821 atctaaccgg cagcgctggc gaaagcatgc ttgaaaatta cgggacattt ataaaaatgc 3224881 agctgtttta tgcagcatcc agtatcgtta ctgtcctgat cgggatcatt gtagccattt 3224941 tcgtgctggt ggtaatcggc attgctgctt ttgagaacac gccttcgtat gatgatccgg 3225001 attcttatta ttatgaggat gatccggtgt ttgaataatg atgagacagg acagggcatg 3225061 agttccatat aaacggaacc atgcctattt tatttgacta ttcaaagcag gccggcgtaa 3225121 acaccaaatc ctgaagcaag catacaatag acatctctag tagaggaaat caacaaagca 3225181 acgctgttac ccagaaatga atatcaaaaa aacggatgaa gtcggaatca atccgaaacc 3225241 gcacttttta tttcgggtgt ctgcatgcaa aaaaacacac ccggatcgtc tggaaaatct 3225301 caacaatccg ggtgcagatc ttctttaata catttttttg cgtctgtctt cctcagtcaa 3225361 aaattcaaca aaactccgca tcgcaaaagg ctcttccttt atttgtcgtg cgtaggagct 3225421 tttccgctct tctgaaagga tttcgctctt tttgatcctg ttcagcatat agatgtgaac 3225481 cgttttttgg atttgtttat gctgatagcc tgcctcttta aaaaatgcga gcccgagcgc 3225541 cgccaaaagg gcgaatatgc ctgcgctgat cagggactcc ctgtcagctg aagcatgaaa 3225601 tagaaaagca gctaaattaa agagagagaa tgcagcaagc ggaatagcaa gaaaacggta 3225661 aatgacggtt tttttcatga aaggctgtac ggccttttga attttttgca tttctgtttt 3225721 gatgaacccc ggcatttgtt cgactctgta aaagttcata taatcctccc cctttatttg 3225781 atgtttcaag cttcacgaac gttatcatat gtgtttattt taacgcaggt gcaagctggt 3225841 tttaaagaaa tctgcccgta tttttcacga agaatctgga tcgccgctct ttattctttt 3225901 aaaatgtgag tgttataatt tgtaatggga atcagatcac tgttattcat ggaatactaa 3225961 tggcaatctt cttgataaat atgaatgagc ggggttacaa agtgagtatt tcttccatcc 3226021 ttttatcact ttttttcatt ttaaatattc ttttggccat cattgtcatc ttcaaagaac 3226081 ggcgcgatgc cagtgcatct tgggcgtggc tgcttgttct tttctttatt cccgttttag 3226141 gctttatttt atacttatta ttcggccata atctcagacg caagcatttg tttcaatggg 3226201 aagaccggaa aaagattgga attgaaaggc tgctgaagca tcagcttgaa gatttagaaa 3226261 ccaagcaatt tcagtttaac aaccgggcaa cctttgataa caaagattta atttatatgc 3226321 tgattatgaa taaccatgct gtgtttacag aggataattc agttgacgtc attacagatg 3226381 gacgggataa atttcagcgg ctgctgagtg acatttcaaa ggctaaggat catatccatt 3226441 tacagtatta tatttataaa ggcgatgaat taggcaaaaa attgcgggac gctctcatcc 3226501 aaaaggcgaa agaaggtgtt caggtcagag tgctttatga tgaactcggg tccagaacgc 3226561 tgagaaaaaa gttttttaaa gagcttcgcg aggctggcgg gcatgtggag gtctttttcc 3226621 cgtcaaagct caggccgatt aacctgcggc tgaattaccg gaaccatcga aagcttgtga 3226681 tcatagacgg tatgaccggt tatgtcggag gctttaacgt cggagatgag tatctagggc 3226741 ttaatccgaa attcggttat tggcgggata cgcatatccg gctgcaagga acggccgtgc 3226801 acgccatcca aacacgattc atccttgact ggaaccaagc ttctcatcac catacgctga 3226861 catatattcc aaatcacttt cctgattacg gcccaaaagg caacgtcggg atgcagattg 3226921 tcacaagcgg ccctgattcg gaatgggaac aaattaaaaa tggctacatc aaaatgattt 3226981 cgaacgccaa gcgttccatt ttgatacaaa caccttattt tatcccagat gcaagcctgc 3227041 tggatgcttt aaggatcgct tgcctttcgg gcattgacgt taacattatg attccgaaca 3227101 agcccgatca cgcctttgta tactgggcga cactttcgta tatcggcgat ctgctgaaag 3227161 ccggagccac tgtctatatt tacgataacg gctttattca cgcgaaaacc atcgtggtgg 3227221 atgacgaaat cgcttcagtc ggcacagcga acattgatgt ccgaagcttc aggctgaatt 3227281 ttgaggttaa tgcatttatt tacgatatca ccattgctaa aaaactggtt tcaactttta 3227341 aagaagattt gctagtatcc agaaaattca cctatgagga gtatctgcag cgcccgttgt 3227401 ggattcgaat aaaagaatcc gtctcgcggc tgttgtcgcc gatcttataa gatgcgtaaa 3227461 cccccggcct ttacggccgg gggttttcct gatggtcaca gtaaatgatg attgcctccc 3227521 gcaaaaaagc ggcaagacct tctccatatt gattgattga atcggtaaat cgctcgtcag 3227581 tgatatacac ttccccgagt cctctgaaaa tgtcgagtgt gcaatcgtaa tgatattggc 3227641 aaatatgatc gcgaaatgcc cccacagcgg cctgaatctc tgcatcatcg ggcccatgct 3227701 tcattcgcgc cgcaattcgt ctgtaaatcg aatcaaattc agccatgatc gtgcgccaat 3227761 catctgccga gtatgcagat gtccttttct ctgtttcttc tgcgatttcc tttccataca 3227821 gctttctgac ttcatcagcg tatgtctgct ggtgctcttc aatgtctttc atgcttaatc 3227881 cggcaaataa atccctctta ttcatcgttt cccctccatc aacggacaaa agcgtcctgt 3227941 caattgtttg aatcatctca tccattcttt gttttttctt catcaatatc tccttttgcg 3228001 actgaagtgc cgctttccgg tcaaaattcg gatgatccag catctcttta atctcatcca 3228061 gacgaaaccc gatttccttg aaaaataaaa tctgttgcag tctttccagg tctgcgtcac 3228121 tgtacaaacg atacccagca tcagtaagcg ctgaaggatt cagaagctca atattgtcat 3228181 agtgatgaag cgtccgaatg ctaacgcctg atatctccgc cacttgttta acttgatatt 3228241 tcatacataa cacctcctct tttttatcgt aaacaatcac gcaacgttag ggtcaatccc 3228301 caaaatgtta ttttctatat acaaaacttc tcacaaatag tgtataaaag aaaagtgagt 3228361 atttttttgt aaaggggagc cagtatacat gaatcctgaa acaatgaaca aaaccctcat 3228421 cagcatttcg aaatggggaa aagctacagg cattttattt attattatgg gcgcaattac 3228481 cgcgctttca ggcgcgttct tttttctaat cggtgccgtg ccaggcgtac tgcaaattat 3228541 ttccggtatc tttttgatga ggtcagctag ggaagcaggc caaatggctg aacacaatag 3228601 cggacagtct gaagacttaa tgctggagaa ttacgcgaaa ttcgtaaaga tgcaagggat 3228661 ttatttgatc gtaagcattg ctgtatccat tcttgcgatt atcgccttct tcatcttttt 3228721 aatgcttggg attgctgacg gccttttcag cgatacgtac agcacttatt aatgagaaaa 3228781 acccggagct ggctccgggt tttttattat tccgcttcgc ttaccactgt gaagcgttca 3228841 tttttgtgtt cgggatgttc aagctcgtcc aacacggcaa tggcataatc tgcatagctg 3228901 atatagctgt ctccttttgc atttacgatg acattgtctt ttcctttttg gtaagagcca 3228961 gtccgttttc ctgctggatc aaaaaatgcc gcaggactga ggaacgtcca ggaaatggag 3229021 tctgtctgct gcaaatcttt caggttctcg ccttgatttg atgcagttgg caaatattct 3229081 ttcggaaatt ccggcgtatc cattaaacgg gttgttttgg cttcatcaac aaacaggctt 3229141 cccgctccgc caacaacaag caatcttgtg tgcttcgcgt cctttaaaat gctgatgagt 3229201 gctcttcctg cttcaacatg aagatgttct tggccgggtg ctgctccaaa agcgtttacg 3229261 accgcgtcga aaggcttgat gtcttccgca gtcagttcaa acacatcttt ttccaaaatc 3229321 gctacgtctt gctcctgcac ttttgaagcg tttctgacga tggctgtcac ttcatggcct 3229381 ctttttttcg cttctttcaa aatctcgttt cccgctttcc cgcttgcgcc tataatacca 3229441 attttcattt ttcatttcct ccttatttgt aacaatttta gttacatgtt agcggtgaga 3229501 agtcatccct tttgattaaa agagatgatt cataacatct tttaatgact tgcttgccag 3229561 ttcattttcc atcgctcttt gcacactttc aaacgtttca tccagagcgt tctgaatttt 3229621 tttccctacc ggacatttcg gattcgggtt ttcatgaacc gcaaagagtt cttcttgctt 3229681 ttggacagcc cggtacactt ctaaaagaga aatatcagca ggatcttttt tgaggcttgc 3229741 acccggcacc ccggcgcgtg atgtgagaat atcagctttt ttcagcaggc tgatcattct 3229801 tcgcacaact accggattcg tgttgacact gtctgcaatg atttctgaag atgttttttc 3229861 atccatcgag atgagggata aaatatgaat ggcaacagca agacggctgt taatcatgtt 3229921 ttttcaccac cgttgtaact ataatagtta catttgattc gtttgtcaac atctaatata 3229981 cactaaatac atgggttttg tgcaccgttt ttagtcaata gaacggccgg atgcactccg 3230041 gccgcgtctt atcaaaataa gaaatatctt tgtccaagtg ggacataatc gacaggctgg 3230101 caagacaatt cctccccgtc agcaaagacc tgataggttt ttggatcaat ctcaatcttc 3230161 ggcaaagccg aattcagctt catatccagc ttgctcagct ttctgatatt tttgactgga 3230221 gaaatccttt tttccagccc taagctttcc gccacaccac gctctatgct tgcctgagac 3230281 ataaatgtaa tcgaggttga gcggttggct tttccgtaag acgcatacat ttggcgcatg 3230341 aaaaccggtt caggagtcgg gatggacgcg ttcggatctc ccatttgcgc acgtgcaatc 3230401 atgccgccct ttaagaccag ttccggtttc acgccgaaaa ataccgggtc ccacagaacg 3230461 agatcagcaa gcttcccttt ttccaccgag ccgacctcat ggctgagccc gtgcgtaatt 3230521 gccggattaa tcgtgtattt ggcaatgtac cgttttgcgc gcacattgtc attcccgttt 3230581 tcaccggcaa gagcgccgcg ctgttttttc attttatcgg ctacctgcca tgttcggatg 3230641 atcacttcac cgacccgccc catcgcttgg gaatccgatg atgtcatgct gatcgcacct 3230701 atatcatgga gaatatcctc cgcggcaatc gtcgccgccc tgattctgga atggctgaat 3230761 gccacatctt caggcacttt cgcatctaaa tggtggcaga ccatcatcat gtcaagatgc 3230821 tcatccatcg tattaacggt ataaggaatg gttggcgttg tagatgacgg cagaatgttc 3230881 gcgtaagagg cgagcttcat aatatccgga gcgtgaccgc cgcctgcccc ttcaatgtga 3230941 taagtatgaa taacccggtc cccgatcgcg tcgagcgtgt tttccaaaaa gcccgcttcg 3231001 ttaatcgtat cggtatggat ggcaacttga atatcagcct cgtccacgac ttccatacac 3231061 gttttaatgg cgcttggcgt cgttccccag tcttcatgga gcttaagacc gatggcgcct 3231121 gcttccacct gctcgatcag cggcgcttta tcggatgcat tcccttttcc taagaagccg 3231181 acattgatcg gaaactcctc ggccgcttcc agcatcctcg ccatatacca cgccccggac 3231241 gtacatgttg tcgctttgct tcctgtagcg ggtcctgttc cgcctcccaa aagggtcgtc 3231301 acacctgaag aaagcgcaac ttccatctgc tgaggacaaa taaaatgaat gtgcgtgtcc 3231361 actcccccgg ctgttaaaat tttgccttca ccggaaatca cctctgtccc cgctccgatg 3231421 accatgtgcg gatcgactcc atccatgata tcaggatttc cgctttttcc gacaccgaca 3231481 atccggccgt ctttcacacc gacatccgct ttgacaatgc ctgtgtaatc caatagcacg 3231541 acgttggtga taaccaaatc caaagcgccg tccttccctg tgattctgcc gttttggccc 3231601 atgccgtctc ggatagtttt tccgccgcca aagatcattt cttcaccgta tactgtgaaa 3231661 tccttttcga cttcgatcca taaatccgtg tcgcccaatc tgattttatc gcccgttgtc 3231721 gggccaaaca gttccgcata ttcctcccgt gacattttca tcggattaca ccctccatcc 3231781 agccggcttg ttttaagttg gccaacgttt tttctttgcc gcgttcatcg ataaacgtgt 3231841 cggccattcc gttcagccct ctaattgtct tgcgtcctct gatttccact agtgagaccg 3231901 ttttctgctc tcccggctca aaacggaccg acgtgcctga tggaacatca agacgcatgc 3231961 cgatcgccag ctcacggtca aataataaag ccccgttggc ctccgcaaaa tgaaaatgcg 3232021 aaccgacttg aatggagcgt gatccggtgt tttttaccgt tacctcccgt atctcacggc 3232081 cttcattaat cgtaatggtt ccctcagcaa tttgaaatgc tcccggcttc atgacttcac 3232141 ctccgcagaa attggctgat gtaccgtaac aagctttaca ccatccggaa atgtggcctc 3232201 cacctgaatg ctgtccagca tctcaggcac accctccatc acatcttttt ccgttaatac 3232261 atggcggccg gcttccatca gctctgctac tcccttccca tcacgtgcgc cttccataat 3232321 aaagcaggtg atataagcag cagcctcagg atagttcagc agaacgcccc gcgcctttcg 3232381 ctgtttggct aattcccccg ctgcaaaaat gagcaatttc tcttgttcaa ctggtgtcag 3232441 tttcatctgt agtcctcctt cttttgtcat ataaagcaga tgcggctact acgaatttgc 3232501 ggaacagtca ggcgggacat cacctccctt tcttcgagaa tgggggtcat acggtaagat 3232561 gcctttcaaa gcggcatgcc gtttcttcat cagccttgcc atggtcaaca accgttcccc 3232621 tgtcgatcac ggaaagatca gattaacgcg ttttccagac tgcgctcgac taagataaca 3232681 aatgtctttt tttctggaaa tttctataat aacttgtctg actagttcga caattaaaat 3232741 ctgaattcct tccaattgtt tattaagtaa aatatttttc agatttacca tcagcgctct 3232801 ggtgattgca agctgctgct gttgaccgcc ttttcgtttt gaacaaacgt ttgattaaaa 3232861 caaatagccc cctctgttta gccggagtcg gcctaataca gcgacaatct gccccgggcg 3232921 aagctaaggc tgtgcaaaac catcgattga tcataaccag acgttacatt cctgatggca 3232981 gcccgttgtt ttgctccgca accggaagca tggcatggag gccagtctga ggcgccgacc 3233041 tccacgatac cgagaacccg actattgcca ttaactccgc atcatggacg gtcacttcgc 3233101 tgatcgccac cgttcctctt aatgagtgaa gaattccggc cttcactgaa tccccgcttg 3233161 tgtcgatatc aactgttttc tcgcactccc gtggcttccg acactttctt cggtgcagta 3233221 cattccgtca tcaaaacccc tttgtttgat ttcttcaaat gatgttataa aagtttacaa 3233281 cttatgtcat cattatatag aagaggccta ttaattcaaa gaatatttaa aaaatttagt 3233341 taccttgacc aaatcagctt ctttttttgt tatatttatt cacatcagaa aaagcgaaaa 3233401 aaaaagacaa gaaacatttc gtttcctgcc tcttccgtac gattaatctt tatctgaaaa 3233461 tttatccttg gctttcccga tatccttttg gatttcgcct tttgccttat cttttttgcc 3233521 ttcagcctgc atgtccgttc tgtcagccat atctccgact ttatccttca cttctccttt 3233581 ggctttattg aagccgccct tcattttgtc ttttacacta tcgttaccca tgttaattct 3233641 cccctctcaa ttatgtgtgt acttgttaac ttcccgatct gagaggcaat aaacattcta 3233701 atgttattta tcgatttcgt agcgctctcc gtaacggagc accttgtata tcgccagccc 3233761 gtctgatgac tttttctccg aatatcggac cggcagcagg gcaaaaaaca cataatacgt 3233821 agaaaaatag acaaactgat agaaaaacac attcggcttt aatacactgt gtataatcag 3233881 cagattgatt gcaaaaatcg tgatgaggtt aaacaagcag ccccctgcat acacgagtgc 3233941 atttgagaat cgattgtcaa ttttcaactc cccgtaccgg caaaaagaat cgataaaata 3234001 aatcgttctg aaccgtatgg gtccaatttt aagcagcgtt tttcccatgc ctatatccaa 3234061 cgatcccttt ccgccaaaaa taaaagccat aaagctgtgc cctgaaacat gtataatctg 3234121 tacaagcggc agaacaatga ggaaagacca cagaaacttc accatatcat taaaaccaaa 3234181 cattgaattc cccctcacat gcatatctgc atcccaaaac ggcttttgtt caaaaaacag 3234241 tgctgtagcg atttttcctg ttctccccgg aaataaacgt tccgatgctc cccttttttt 3234301 gcataaaaaa aaaccatctg ccagcagatg gttttgtctc atacttcata taaacaatcg 3234361 ttcctttgaa tcatctctct catgctgacc gctttttcat aaaaatacac cgcttcttta 3234421 tattgttcgc gatgactgaa ataagaggca gcatctaaag caaattcttc aatatataca 3234481 tacaggccct tttcttccat ataatcaaat acttcttgaa tcatattcaa attgacagat 3234541 tccacatata atgcctgcag aaatttatat tttgccagac tgaagaagtc gtttcgtttt 3234601 tgggcaatgg caatcccttt ttcatagtac cgtatcgcgg cttcgctatc ttgttttttg 3234661 aaaagaacgc gagtcaggct gaagagcgct tttggaagct gttccagctg ataatcctcg 3234721 aagacaggaa gcgctttttc aaagtattcg gcggcctgat ccagctcccc cttgtcatca 3234781 tagcaattac caatattata aagggctgat ccgatcaaac ggggctgtcc ttccaataaa 3234841 gcaaggcgat acgcgtcatc taaatgttca agcgcttttt cataatttct gtagtcaatg 3234901 tagtttcctg atatgacgaa atggcattga attcttctga ctctgtaaaa atcgtgagcc 3234961 ttatacgtct ccagcgcctg tacggcatgg ttcatggaaa agtgcgtctg cttcataata 3235021 taaaagactt ccgccacttt aaaatgaaat tccgctcttt caatttcatc ttctacaaac 3235081 gcaagcatct tctcagcttt ccgataaaag gatatagccg agatgtaatt gttctgttca 3235141 aattcgtaca ttcctctaaa caagtgaaaa taatactcag ataatccgga gatgctgtcc 3235201 tgattgcttt ccagcgtttt gatcaattca cgatattgaa gctgagattc ctcgtgcagg 3235261 tcaggcttta cataatccag cataatttgg tgccggtagc tgatcagctg ataatacagg 3235321 agaagcagct gatcctcttc catctgttcg atatctagat caatttcttc tttcagtttt 3235381 acggcatcag ccacttgaaa tgctaaaatg tgcttatacc acttattgat tttcactcct 3235441 acttgagatg acgggatctc gtacgcggcc atgcccctcc aaccctttct attttctaat 3235501 tggttatatt ttatcataat gtatggcttt ggaattaaat tttcttacaa tgattccttc 3235561 tttatgccta tccttatata tttcggtttt tctacgtatt ttttgcactc ggattctaat 3235621 aaaaaagctt accggacagt gccgataagc ttttgacttc aaattaaccg ccaatataag 3235681 acatttccac tttctttttg ccagatgctt ttgatagcgt acgatcgact gaatactgat 3235741 cgatccgatt tttccatact gtcccgatca tttctgatag ttcgtcatca cttaattcct 3235801 ggcgaaccgg agctctgagg tcaaatccgc ttgaagcgaa taagcaggta aacagctctc 3235861 ctctcgcaga aagacgggct ctgttgcaag atccgcagaa tgcatcagat acagatgata 3235921 tgacgccaat ttctccggag ccgtccaagt agcggaatct ggaagccact tcgcctatat 3235981 aattaggcgc tatcggctca accggcatgt gtttattgat caaatctatg atttccgcct 3236041 ttgtcatgac gtctttcttt tcccattggt tggtgttgcc tacgtccata aattcaatga 3236101 atctcaggat atgccctttt tctttaaaat aacgggccat aggcagtata tctttttcat 3236161 tgacgccctt ttgaacgacc atattgattt taacaccgag ccccgcttgc ttcgccgctt 3236221 caatgccttc cagcaccttg ctgacagaaa caccgcgccc gtttatcttc ttaaaacgct 3236281 cgtcttctaa agaatcaagg ctgatcgtaa cccttttcag cccagcctcc ttgagcctct 3236341 tagcataaac aggcagcagt gatccgtttg tcgtcatcgc gatgtcacga atacccggta 3236401 tgcgggccag ttttttgatt aattccggca tatcctttct catgaggggc tctccgccgg 3236461 tcaagcggat tttttcaacg ccaaatcttg tgacaaacaa tgtcgcaagc cgttccagct 3236521 cctcaaatga aagcagctcc tctttcttta aaaaaggata atccgggccg aataattcgg 3236581 cgggcataca gtacgtgcat cggaagttgc agcggtctgt aacagaaatg cgaaggtctc 3236641 tcagcggtct gtttctttta tccaacatct gacgcgactc tgtaatcata gctacagccc 3236701 cttcctactc cctgattctc tcagggtgtg tatatacatt aaatgatccg tttctgacaa 3236761 atccaatcgc tgtgatattc aattcttcag ccatttgaat cgcaagctcc gtcggggccg 3236821 atttggaaat gacaatcgac acgccgattt tggccgcttt taacaggacc tctgatgaga 3236881 ttctgccgct gaacacaatc agtttgtcgc gtacggacat cccgtttaga aggcagtgtc 3236941 cgtatagttt atcaagtgcg ttgtgccgac cgatatctgt gcgcatcaac agaagcttct 3237001 ctgtgtcgca aagcgccgca ttatggacgc ctcccgtatc ctgaaacgtc ccgctccctt 3237061 gctgcatgtc tttcataagc gccagacatg cctcaggcga tatcttgatt tggctgacag 3237121 ccgtcttggc tgttttgaca tcctgctgaa aataaaaatg acggcccttt ccgcagcatg 3237181 agccgatcac ccgtttcgta taatcctttt gatccaatgt ctcagggtga acgaggtcga 3237241 catatacaaa accgagactt tcatctattg taaacctttt aatttctttt tgaaatcgta 3237301 taacaccctc tgatgcgaga aatccgatga caagctcttc gatatgctca ggcgtacaaa 3237361 cgagcgtcac aaattcactg ccattcagta tcactgtcaa agggaattcc gtcaccatcc 3237421 ggtcttctac tttgcttatt tccccttgtt catagcgcca tacatccctg accgcagtta 3237481 ctttatcgtt caatgtctct tcccctccgc aatgttcctg cctttatatt ttttcacact 3237541 cctcggattt tgtcgaattc tgagacacaa aaagagccct ctatataaag ggcttttaca 3237601 ggatgtgatg acggcggtgt ttaggcagga cgcctaagca tttagccgcc gttcctttta 3237661 taacacgtga gcaccaatgt gcattgacaa cgaacgcggg gtttgtcgac acgctgagac 3237721 acctctgtat aaaggactct atgtttgatt atgctgattc tttttcagaa ccgtaaacag 3237781 cacaatagct gcgatcaagg tgagaatgct gacaaaaaag aaggctgcca gttttagaag 3237841 aacaccaagc aatataaatg caacggtggc tataagaaaa atcattccga ataatttcat 3237901 atgttcaacc cctttttagg gtatcattcc cgcccaaact gtttttaaac caataaaaaa 3237961 ggcgcctggg ggagcgcctg atctttaggt tccttactca gtaaattttt gtgcttcttt 3238021 ttcccaagcc tgttcgaact catccgcact gttcgctgaa atatattctc cgccgccagc 3238081 gacagctgct tgtttcatct cttcattacc cttgacatca aagttgaagc caatgatgtt 3238141 tacaatcgta tccacatttg atgcacggag cttttcgatt tccgccgcag ggtctccgcc 3238201 gcacgtttct tcaccgtcag tgattaaata caccacgttt ttcccgtctg cgtcaaatgc 3238261 ttcaaattct tttcttgtgt ctgcaagtgc tttggcaatc ggtgtccatc cagtcggctt 3238321 gagctcactc aatgaattgt caaacagaga cccttcatat ggatgaaggc cgtaaatggt 3238381 ttccgtcgta ctgcacgaaa gggctttacc ggacagttta ttgttccctg catgcccgaa 3238441 aacgcgaagc ataagatttg tatcctttgg aagaagttcg gcaaaagatt ttactgattt 3238501 tttggcaatg tctattttgc gctctcctcc tgttttttga accatgcttc cgcttccgtc 3238561 aaacaaaaca gctacatttg tatcagcctg tttctcagcg gcaaaagacg gggaggcaat 3238621 ggaaacagtc aacaatccaa tgataccggc agccagcaat tttttcatat gattacttcc 3238681 tttctttttc atattttcca actatatgtt ggattcttct ttatgctaga atacgaaaat 3238741 gcaaaaagat ataggacatg ctgccttttg tgctgctttc acgatctgtc caaaatcgct 3238801 tgaaatgccg ttcattttta gccatttccg cccagaaagc ataaacagct tgtgtgatca 3238861 ttcattcttt tttcgccttg attatgacag aaaaacggaa atctgctact atgctacagg 3238921 cagacagcta attagttttg aagtttttgt tacatacaaa aagaggctga ccatcaccag 3238981 cctctttttt cttatttaga taacattagt gattgctgag tgaaaatttt ctcaacatct 3239041 ttttgggtat aagccgggaa gtattcaccg ccgcctactt tcgcaattgc gttcagctgg 3239101 cctttgtatc cctctttata atcaaagccg atcacattaa cagtgatatt gtctttttgc 3239161 agttcctttg ctgttttaat cgggtttcct ccgcacgttt cctcaccgtc tgtcaacaga 3239221 tacaccactt tttccccttt tgcatcaagc tggtcaaaag aagatttcgc ctcgttcagc 3239281 gctttggcaa ttggcgtcca gccagtcggc ccaattgtat tgagagaatt gaggaagctt 3239341 tgctcgttaa agctttggaa gccgtatacg ttgcgaatgg cttcacatga ctgaactttt 3239401 ccggaatttt tattgtttcc ttcagagcca aacacgctca ttttcacctg agttccttct 3239461 ggcaatgagc tcgcaaactt tgaaatttct tttttggctg aattaaattt agatacacca 3239521 tctattcttt tcgccatact tccgctggca tcaagcaaga ccgccacgtt cgccggcgct 3239581 ttagcctccg tttctgtctt ttcagctgca aaagcaggtg aagttaatcc aaaaagcaat 3239641 cctgtcatca tgatcagtga aaatcttttc ttcatgttcg taccccttta ccaatttgtt 3239701 tctgcgtgca gatgttcaac gctgaacata atctatcgta atcaacaaaa accgagaaat 3239761 aaatagggcg ggcttcccca ttgctgttgt ttacttttgc atagaaacct atgtttttat 3239821 tagtgatttc cacctaacgc ccctatgaaa agagaagatt gtccgccttt cggctttcgt 3239881 tatatgagtc tgtcgaagtc tgtcgacaaa tgtggatgac tttaccacaa tctcaaagcc 3239941 tgaaatcagg aaaaaaggac tgatccttaa agacggtcag aagctcctct aaaccgtttc 3240001 agctactctt agataaaaga tattcaggaa cagaaaaaga cgcccaatga gcgtcttttt 3240061 ctactttttc gccatatatt tattcaaaaa cgcatctgcc tcagaaattt gtgtgccttg 3240121 gtaatagtac tttacaatgt catcaaccgt tttgccttct ttggccataa aattcgctcc 3240181 gtattggctc atccccacac cgtggccaaa tcctctcgtc gtgactgtaa ttgtgtctcc 3240241 atttcgcttc cattcaaaat cggcggagtt gagacccaac ttttcacgta tgtctcttcc 3240301 tttcagcgtc ttgccgttaa tgacggcagt tgcgacctgg tggcccggtg tctcgccggt 3240361 aatcttccct actgcgctag atccatccag cttgacgcca agcttttgct gaaattctgc 3240421 cgctgtaaag gttttcgttg ccttatattt cggagacttt ttatcccatg ggcttttgac 3240481 gctttttaaa tatgggatag cacttgtcca ataagcttct gcattctctg tgtagccgtt 3240541 gcttgtggag aaaaaggatg cttcaatcgg ctggttgttg tacgttaaga ttttgccttg 3240601 cgtactggct accgcatctg tgattttctt cagttttgtc tcatagcttg tgccccactg 3240661 ttttttcagc tccgctttgc ttttatacac ctggaacatc tgtgtatcat ccaccagtga 3240721 gcctttagga gcttctaccg ctgaatttga caccatcagt ctgacaataa atgttctggc 3240781 ggcaagcgcc tgggctttca gcgcttcagg tttaaaggtt gccggcattt cggaggcgac 3240841 gactccaatc acatactctt caagcggaat gttttctacg gattgatttg cggttcgata 3240901 gacgggaata gaaacaggtg atgctttcaa tgtttctgct cctttcgatg ctggtttcgt 3240961 gctgactgct gtcttttctg attctacgct ggcccccgct tccttattat gctggaatgg 3241021 tataaccaag agtgtgggaa ccaagagaat caatgcacat agtacggata gtgtgattgc 3241081 gaattgtttc atattcagct gcctcctgct cgggattcga ctctagtcta gtctatgggc 3241141 agggacaagc taatatgact ctcgttttgg acagaaactt tatttgtcat ttacgtattc 3241201 ttttttgcta ttttgcgcat aatgatgata atacacaaaa aataaaaaac cagtatgcca 3241261 gagtgacata ctgattttca agtaagttta tgcatttaag tcagaaacga cttctttatt 3241321 ctcttgctca gaagcagact catcatttac acgttcgatg tctgcgccca gagcggcaag 3241381 cttctgatgg aaatcaacgt aaccgcggtc taagtgcttc aattcagtaa cacgtgtgtg 3241441 accttcagcc actaaccccg caagaatcag cgctgcacct gcacgcaaat cagtcgctgc 3241501 aacttcagct ccctgaagct gtacaggacc gttaatgatg acagaacgtc cttcaatctt 3241561 gatatcacca ttcatacggc ggaattcttc cgcatgcata aaacggtttt caaaaacggt 3241621 ttctgtaatc atgcttgtgc cgcttgcacg aagcagaagc gccatcattt gtgactgcat 3241681 atcagtcggg aagcccgggt gaggcattgt tttgatgtca atcggtttaa gctctttcgg 3241741 gccgatgaca cgcagacctt caccttcatc cttaattgtt acacccatct cttccatttt 3241801 tgcaattaaa gaggtgaggt gctcaggaac cgctcctttt actaatacgt ttccttcagt 3241861 gattgcagca gcaaccataa atgtgcccgc ttcaatacgg tcaggaataa tatggtgttt 3241921 tacgccgtga agcttttcga ctccttcaat tttgatggtg ccggtgccag ctccgcggat 3241981 ttttccgccc atgccgttga tatagtttgc taaatcaacg atttcgggtt cttttgccac 3242041 gttttccagc gttgttgttc cttcagctag agcggctgcc ataatcaggt tctctgtagc 3242101 tcctacactt gggaagtcca gataaatttt tgcgccttgc agtcggcctt ttacttcagc 3242161 ttcaatgaag ccattaccga ctttgatttc tgcgcccatt gcttcaaaac cttttaaatg 3242221 ctgatcaatc ggtctggaac caattgcgca tccgcccgga agtgcaactc ttgcatgacc 3242281 tgtacgcgca agaagcggcc ccatgacaag cacagacgca cgcattttac gaacatattc 3242341 aaaaggtgct tcagtttgca aagcgtatga agcatttaca gtcacttcat tattttcaaa 3242401 atgcacatct gctcctaaat gacgcaacac ttcgttaatt gtatatacat cggagagcgt 3242461 aggtacatca caaattacgc ttttttcttc acttgctaat aaagatgcag cgataacagg 3242521 taaaacggca tttttagcgc cttcaacttt gactgtgccg tttaacttct gaccgccgcg 3242581 gacgatgatt ttttccaagg tattcccctc cgcgtcccta aattctctat attaatattc 3242641 agtcgtaacg attggtgtgc caaccgtaac ggtatgtttt ccgcccattc ctgcacttct 3242701 aagtgcaatt tgcaaattca ttttatgttt cgaggtcata atgtactctt cccactcatc 3242761 tgtaaacgca gaaatagaaa cgaaatttgg ctcaactaca tgttctactg atcttgcttg 3242821 aaattcattt aataactgat ttgctttttt ttgcaaaaca atattcatat tatcatctaa 3242881 gtgaccattt agacaagtaa aaataactac tttttcttgg aatatcccaa gtgtctcccg 3242941 ttcaaactgt tcatatgtat cattccagct atccggtgtc tctagactca tttgctcata 3243001 taataaatac gaagttggat tgtgtttttt gagggttgtg acaagctgca gtctaaaaga 3243061 agtacgattt tttttgtcag tatatgtgcc aattgccttt atcattttat cttcccgtgc 3243121 aatcacccaa tcatattgac gatactcttg ttttaaacgt tgcacttttt gataaaattc 3243181 tttttcggtc agtgacaagt tttgttttgc atgcaatgtc cacttatcta ttgacacatc 3243241 ttgacgttcc atcccctctg ccatctgtgc taacggcgtt aattcactcg catgaatggt 3243301 atggaaaaca gcaatgacga agcttaacat gacggaaatg ataatagcgt ggcttacttg 3243361 ttttttcttc atgttcatct ctccccctta tccccagttt taccggaggc aagaggcgcc 3243421 atacgtaaaa atcttcgtca aaactcgagc tattcgcttc aacccgcttc tcccaaccat 3243481 ttaataatgt tcaaaaccta ttaaaataga tagggaagct gctgtgaata attgaggtaa 3243541 tctaaaaaga aattggcaac ggccgttcca atggcgattg tcagcaaaat catcaggagt 3243601 cttgcctgca cgactttgcc ttttttgatt aacggatcta tattgacggc ttgcaacgcc 3243661 caccaagtca ctgctataaa aatcaggtga acgacaatgc cgattgcagc ctgctgtccc 3243721 aatacactca tctattacac tcctttctct gcgttcatac cctttcttat tatataagaa 3243781 gcacagataa agatgataca ttttatacag aacggaataa tcagccaaat ctagggctaa 3243841 tccccgctta aagtgcgatt cttttacatg gtatacttta ttggaaagga gctggcaaat 3243901 gtgaatcatt ctttttttca gcctgaaaag caatatggtg aggacctgcc aatttttgat 3243961 caggaatggg aagcaattgc attctattat gattatagac agtcacagat tgaagaactg 3244021 aatgaattgt gtcagttttt taacatttct cttacctata cgagagaaag ccttgaagag 3244081 cttgaaaacc tctattttca aagtatacaa gaacttttgc ttgctgattg gaatcttcct 3244141 attgaagaat tcgagaaaat gatcagtgtt tatcttatag attgtgtgat tgcccgccat 3244201 gaagatgctg aatgggttgt aaaaccttat ccctataaag acggcgctta tacacttggc 3244261 tttagaagac atcgcaaatc gtggcataca atgaatgcct gtgatggttt atacctgcgt 3244321 ccaaaagagg atcgcccgtt gctgtcgctg tttgattctc ttgtgcgttc ataaaaaaat 3244381 ccttctcata aagagaagga ttttttctta tttccctgct acatccaatc tgttcaaagc 3244441 ccgctgtaac gcaagctcag cccgacgaat gtcagtatca tctgattgag aattcaaacg 3244501 ctcctgcgcc cgctggcgtg cagcttcagc gcgctcttta tcgatgcctt ccgctgtctc 3244561 ggcagcctgg gcaaggatgg tgacatgatc aggacggact tctacaaaac cgccgctgac 3244621 ggcaaccatt tcagtctgcc cgtctttttt cagacggaca gcgccgattt taagaggagc 3244681 cacggttgga atatggcctg gcaaaatacc gagatcgccg ctttcggctc tcacactcac 3244741 catttcgata tccgcatcgt atactgggcc gtcgggagta acgatattga ctttaacggt 3244801 cttcatgctt ttaccctcct aggaccagat taaacttcta cacccatttc ttttgctttc 3244861 tcaacaactt cttcgatacg gcctacaaga cggaatgcat cttctggaag atggtcatat 3244921 ttaccggcta agatttcttt gaagccttgt accgtctctt ttacaggcac gtaagaacct 3244981 ttttgtccag tgaactgttc agccacgtgg aagttctgag aaaggaagaa ctggatacga 3245041 cgtgcgcggt gaacgacaag tttgtcttcc tcgcctaatt catccatacc gagaatcgca 3245101 atgatatcct gaagctcttt gtaacgctga agcgttgact gtacttcacg cgcaaccgca 3245161 tagtgctctt ctccaacaat ttcaggagca agggcgcgtg atgtagatgc caacggatca 3245221 accgcagggt aaatacccat ttcagttaat ttacgctcaa ggtttgttgt cgcatccaag 3245281 tgagcgaacg ttgtcgccgg cgccgggtca gtgtagtcat cggcaggcac gtagatcgcc 3245341 tggatagatg taactgatcc aacgttcgta gacgtgatac gctcttggag ctgacccatc 3245401 tcagttgcaa gcgtcggctg ataaccaacc gctgaaggca tacggccaag aagggctgaa 3245461 acctctgaac ccgcttgtgt gaaacggaaa atgttatcga tgaagaacag tacgtcctgt 3245521 ccttgtacat cacggaagtg ctcagccatt gtaaggcctg tcaaagcaac acgcatacgt 3245581 gcgcccggcg gctcgttcat ttgtccgaat accatggctg ttttgttgat tacgccagag 3245641 tcactcattt cgtagaaaag gtcgttccct tcacgagtac gctctcctac gccggcgaat 3245701 acagagatac cgccgtgctc ttgcgcgatg ttgttgatta attcctggat taatacggtt 3245761 ttacctacac cggcaccacc gaacaatccg attttaccgc ccttaatgta aggagcaagc 3245821 aaatcaacaa ctttaatacc tgtttcaaga atttcaactt ctgttgaaag ctgatcgaat 3245881 gaaggcgcct gtctgtgaat cggatccttt ttcgcatccg caggaaccgg ctcattcaaa 3245941 tcaatatttt ctccgagaac gttaaataca cgtccaagtg ttacatcacc aaccggtact 3246001 gagattggcg ctcctgtatc tacagcttcc ataccgcgct gaacaccatc tgtagatgcc 3246061 attgcgattg tacggactgt atcatcacct aaatgaagag cgacctcaag cgttaaatca 3246121 atacctactt cgttttcact tgcagctggc tgtgaaattt taatcgcatt ataaatttca 3246181 ggcaagtgac cgtcttcaaa acgcacgtcg acgaccggtc ctaatacctg gctaacgcgt 3246241 cctttcttca tcgctatccc tcctgacaaa atctttctat tctaaagcgg ctgctccgcc 3246301 gacaatttcc gtaatttctt gtgtgatggc tgcttggcga gcgcggttgt aagaaagcga 3246361 aagtgaatcg ataagttcct tcgcgttgtc tgtcgcgttt ttcatcgccg tcattcttgc 3246421 agcgtgctca cttgctttac tgtcaagaag cgcaccgaag attaagcttt ctgcatattg 3246481 aggaagcaaa acctccagaa cctcctcttc agatggttca aattcataag acgccgttct 3246541 ttttccgccg ccgctgccca aatcagataa cggcagaagt tttttctccg ttacttcttg 3246601 agtaatggcg ctgacaaaat ggttataaac aaggtgcaat tcatcaaacg caccgtctat 3246661 aaacatttga atcgtttgac gggcaagatc tttaatttct gtaaacgtta cttcatctcc 3246721 aagtcctgtt aactcggaaa tgatcggaat ctcccgtttc ttaaagaaat cacggcccac 3246781 tcttccgatg gcaatcaccg catactcatc cttagactga tgacgttctt gcatggcctg 3246841 ataagcactc cgtaaaaccg aactgttaaa agcgccggca agaccgcggt cagacgtaat 3246901 gacaaggtat gccgtttttt tcacttctct gctgagaagc atcgggtgct tcacgttgcc 3246961 ggaaactctt ccgacgtttg acacaacctc ttggatttta tccatatatg gcacaaatga 3247021 ttttgcattg ttttcagcac gattcagctt agccgcagat accatctgca tggcttttgt 3247081 aatctgactt gtttttttcg ttgacgtgat ccttgactta atatcgcgta atgaggccaa 3247141 agatttcacc accttttctc ttcatctgcg taaaaagaga gaaaaagaga acctttttct 3247201 ctcatcagca ttcgagttag ttgcttggtg caaatgtgcg tttgaagcct tcgattgcag 3247261 ctttgaagtc ttcatcagca ggaaggtttc ctgttttcgc aattccgtca agcaggtctt 3247321 tatggttttg gtcaaggtac atgtagtact cttcttcaaa acgtctgata tccgccacag 3247381 gaatatcatc gagatatcct tttgtcagcg cataaagaat agctacttgc ttttcaaccg 3247441 gaagcggctt gttcagatcc tgcttcagca cttcaactgt acgcgcaccg cggttcagtt 3247501 ttgcctgagt cgcttggtcg aggtcagaac cgaattgagc gaatgcttcc agctcacggt 3247561 atgacgcaag gtcaagacgc aaagtacctg atactttttt catcgctttg atttgcgctg 3247621 agccgccgac acgggataca gacaatccgg cattgatcgc tggacgtacg cctgagaaga 3247681 acaaatcaga ttgcaggaag atctgtccgt cggtgatgga aatgacgttc gtcggaatat 3247741 aagcagagat atctccggct tgtgtttcta cgaacggcag agctgtaatt gatcctgcgc 3247801 ctttcgcgtc gctaagcttt gctgcacgct caagcagacg ggaatgaaga tagaatacat 3247861 ccccagggaa cgcttcacgg cctggcggac ggcgaagaag caaggacagc tcacggtaag 3247921 cggccgcttg tttagaaaga tcatcgtata caacaagaac gtgcttgccg ttgtacataa 3247981 attcttctgc cattgtaacc ccagcatacg gtgccaggta cagaagcggt gccggctgtg 3248041 acgcagacgc cgttacaaca attgtataat caagcgcgcc gtgtttacgc aatgtttcta 3248101 ctacgccgcg gactgttgat tctttttggc cgatcgcaac atatacacag atcatgtctt 3248161 ggtctttttg gttcaggatc gcatcgatcg caacagatgt tttacctgtt tgacggtcac 3248221 cgatgatcag ctcacgctgg ccgcggccga ttggaatcag tgcatcgatc gctttgatac 3248281 cggtttgaag cggttcatga acggatttac ggtccataac gcctggtgca gggctttcga 3248341 tcggacgagt tttgcttgtc agaatcgggc ctagtccgtc aaccggctgg cctagcgggt 3248401 ttacaatacg gccgattaac tcttcaccaa caggaacctc catgatgcgg cctgttcttt 3248461 ttacttcgtc tccctcacgg atctcactga aaggtcctaa gatgacgata cctacgtttg 3248521 attcctcaag gttttgagcc atacccaaaa caccgtttga aaattcgaca agttcaccgg 3248581 ccatacagtt gtcaaggccg tgcacacgtg caataccgtc accgacttgg atgactgtac 3248641 ctacgtcttg aacttcaata tcagattgat aattttgtat ttgctgtttt atcagcgtgc 3248701 taatctcttc agctttgatg ctcacttagg tttcacccct tctatcgatt ttccccggct 3248761 aattgacgtt caatgcgctg aagcttcccg cttacgctgc cgtcataaat ccggtttcca 3248821 atgcggactt taataccgcc tattaaatcc gtctgcactt catttctgat tctcagtgaa 3248881 gcgactccgg ctttttttgc aaacacttgt gataatggta acatttctgc atccgtcagc 3248941 ggtttcactg aatatacgat tgcgtcttct gtttgacggg ccacatttgc gagtttgata 3249001 aactcatctg tgagctcagg gacaatcgcg gcacgatggc ggtcaatcaa aagaaaaatc 3249061 gtattgagta cggactgtga caaagagcca aatgcatttt gaatcagctc ttttttcttc 3249121 gcagccggca ccttcggatg gttcaacaca tcattaagcg ctttttcatt ttgaaatact 3249181 tgttttacaa caattagctc ttcttctact tgattcagct gagcggactc attggctata 3249241 tcaaaaagag ctgatgcata tcgtttagag acagctgatc cactcatcgg ctttctccta 3249301 cctctttaag atagtcctgg atcaatttct cttgcgcttg ttcatccagt tctttttcga 3249361 tcactttcga cgcaatcatg acagaaagag acgctacttg ctcacggaga gcagaaaccg 3249421 cctgttcctt ttccttcacg atttcagttc ttgctgcttc tttcagacgt tcagattctg 3249481 cacgtgcagc ctgaataatc tcttcttttt gcttctctcc cagtttcttt gcgttttcga 3249541 taagagtttg ggattcctgt cttgcttctt ttaaaagaac gcgctgctct tcaatcagct 3249601 gctgcgcttc tttatttttt tcttcagcag acgtaatttc tccagcgatg tggtcttcac 3249661 gctgtttcat tatgtttaat agcggcccta aagcgtattt cttcagaagc gctaataaga 3249721 ttaacatagc taacagttgg aacaggatat ctccgccgtt aaacgacaat cctagttcaa 3249781 gtggtaattg agacatctac tacggcaact cccttctgca ggtttttctt tgctgatcca 3249841 gcagccgcac ttgtctcttt tcagccggca aggcgggatg cttatcagac ataaagcaat 3249901 ggcgaaggtt ctcttggaat gatcttcgcc atttttagtt catataaggc ttttatgctt 3249961 agccaaagaa cgctaagaat gcgataacga cagcgataat aggaagggct tcaactaatg 3250021 cgatacccat gaacataaga gttctcagtt ctttacctgc ttccggctga cgggcaatcc 3250081 cctctaccgt acgtgaaaca atcaaaccgt taccaatacc tgcaccaagt gcgcctaaac 3250141 caattgcaat cgcagctgct attaaattca tgaaaaagtt cctcctttaa aatgttatcc 3250201 gtttggatat aatgttttaa tgatcatgac tgattttatg agacatgtac accatcgtca 3250261 gcattgtaaa gataaatgcc tggatagcac caataaataa actgaatgct tgccatgcca 3250321 gcatcggcag aatggcaccg attgtaccga caagaccgag agccacgctt tgcgaataat 3250381 ggcttgttgc taatcccgca agcaggccga gaagaatctc accggcgaag atgttaccat 3250441 acagccgcaa acctagagtc agcgtattcg caaactcttc gatgattttc atcgggagca 3250501 tgaatggaac aggtcttaaa tagtctttgg aatattcctt gagccctttc atcttcacac 3250561 catagtagtg ggttaaagca acaaccatca cggctagcgt taatgtaatg gcaggatcgg 3250621 ctgtcggaga cttccaccag agctcatgtc cgattgtaat agagaacggc agccccagca 3250681 tattcgacac aaatatgtac atcagcaatg tgacaccaag tgccaagaag ttagcccctg 3250741 tttttaaatc cattgtactg ccaataatat tgcggacgaa atcaacaatc cattccataa 3250801 agttctgggc ttttccggga cggatcgaaa gcgttcttgt cgtcaatata gcaatcaata 3250861 aaacaatcac actcgccaca gtaatcatca gaatgtttgt cagattaaaa gtaagaccta 3250921 gaaattctat agttctgtaa ccatgattca aagggttttc acctctcttc cattgatgaa 3250981 cgtttaagct ggataaagga atctatcata atgacagggt atattgtcat taatccaata 3251041 actgtacttg ccatatgaaa gtattcggga tttttatagg caacagccac agcaagaatc 3251101 gcattgcacc accgcgctgc gctcccgaga gatcgtatgg actttccttt ctctacagct 3251161 ctgtcaaaag cattcattct tctgacgagc agtaaaaaat taaacaaact gaaaacagtt 3251221 cccagaataa ggcctaaaaa aacggtttta tacgctgtta aaccataacc cagtacatac 3251281 actgccaaaa tgaacaataa atatttgcgt tgtctgctaa atgtaagctt gggatcgtcc 3251341 atcaattatc tgtctcctga tgaaaaaata atgtatagct tggatacggc aaaaatcagc 3251401 ggttaaccct tagtagaaga ccttttttga ccggcaaaac gggcctgttc gaaaaaatca 3251461 ttcatccgca agccttgcag ggatgctgtt tcattcgctt aaataaatcc tcataatacg 3251521 ggtttgctga gaggatttac attgaggatg aggactataa tgaaagctat gaaaaccttc 3251581 tcataatacc ctcgtttagc atacaatagc ccctaacatg tgtcaatctg tttaaagtta 3251641 aaaaactttt tatactttac gtctccacag aatgttcaca ttttcaccta taattgtata 3251701 cagattcacc gaatagcaaa aaactggata aaaaaatgaa accccctttt ggggatttca 3251761 ttttttattt tgttccaaac atgcggtcac ccgcatctcc gagacctgga acaatatatc 3251821 ctttttcatt taatttttca tctagcgccg caatgtaaat atcaacgtcc gaatgatgct 3251881 tctgcaattc ttccacaccc tccggcgctg ctacaagaca catgaaacgg atatttttcg 3251941 caccgcgttt tttaaggctg tgaatggctt caactgcgga accgcctgta gcgagcatcg 3252001 ggtcaaccac gatgaattca cgctcttcca catcagaagg aagcttgaca tagtattcca 3252061 cgggttttaa ggtttctgga tcacggtaaa ggccgacatg tcccactttt gccgcaggaa 3252121 tcagctttaa aatgccgtca accattccca atcctgctct gaggatagga accactccga 3252181 gttttttccc tgagatgact ttcgatttcg cagcctgaac cggtgtattg atatccactt 3252241 cttccagagg aagatcgcgg gtaatttcaa atgccatgag tgtagccact tcatctacta 3252301 actctctaaa atccttcgta cctgtatttt cattccgtat atatgtcagc ttgtgctgaa 3252361 ttaaaggatg atcaaataca taaacctttc ccatactgtg tttcagctcc ttttttattg 3252421 tcccatcaac aattacacac ttctattgat tctacaaaaa aagacattga gtttcaagaa 3252481 catcgtcaaa aaacccgccg ggcataagcc caagcgggtt ttaggatctt aataatctaa 3252541 ttctttatat aaaggaaatt tatcagtcag agcagctaca cgctgtcttg cttcttcaag 3252601 ttttccttca tcttcgtggt ttttcaatgc aagcgcaatg atagcaccga cttcttctaa 3252661 tgcgtctccg tcaaaaccgc ggctggttac agcagctgta ccaagacgga tgccgcttgt 3252721 tacgaaaggt ttttcaggat catatggaat cgcgtttttg ttagacgtaa taccaatttc 3252781 atcaagtaca tgctccgcaa ccttaccagt cagtccgagc gaacgaaggt caacaaggat 3252841 aaggtggttg tctgttccgc ctgaaacgag ctggatgccc tctttcgtta aggcttcagc 3252901 cagacgtttc gcgtttgaaa tgacgttttg tgcatatgtt ttgaaatcgt cctgcaatac 3252961 ttcaccgaat gaaacagctt ttgcggcaat aacgtgcatc agagggccgc cttgaattcc 3253021 agggaagatc gatttatcaa ttttcttgcc aaactcttca cggcaaagga tcataccgcc 3253081 gcgaggaccg cgaagtgttt tatgtgttgt tgttgtaacg aaatcagcgt aaggaaccgg 3253141 gtttggatga aggcctgccg caacaagtcc tgcgatatgt gccatatcca ccatgaagta 3253201 agcgccgact tcatcagcaa tttcacggaa tttcttaaag tcgattgtac gaggatacgc 3253261 acttgctcct gctacgataa gcttcggttt atgagcgagg gctttttcac gcacgtcatc 3253321 gtaatcaata tattgagttt ctttatctac gccgtactca acaaagttat attgaacacc 3253381 gctgaagttg actgggcttc cgtgtgttaa atggccgccg tgggagaggt tcatcccaag 3253441 tacagtatcg ccttgctcca aaatcgtgaa gtacactgcc atgtttgctt gtgcgcctga 3253501 atgaggctga acgtttacat gctccgctcc aaagatttcc ttcgcgcggt cacgggcgat 3253561 atcttcaacg acatcgacgt gctcgcatcc gccgtagtag cgtttgcccg gatatccttc 3253621 tgcgtactta tttgtcaaaa cagatccttg tgcttccata accgcttcac ttacaaagtt 3253681 ctcagaagca atcaattcga tcttagtctg ttggcgttca cgctcatttt taatggcgtt 3253741 aaacacttgt tcgtcttgcg caggtaaatg tttcatcagc gagatcctct cctatccgta 3253801 tcctgttctt tgtttttacc atcactattg tacatggttt ttaaggccga tgtaaaagat 3253861 tatttttaaa aaatctaaat ttttattggt aaaaacgaat attaataact taaatttaat 3253921 ttaaagttcg gaatttattt cactatctta aaataaaaga aaagactggc tatgcagtcc 3253981 tttcattcgc actcataaac cgcccgcact ccgccgatta gtttcggccg tgtacgcgcc 3254041 aatgtcacat gagctgaacc gaggctgttt tgagagacac gcacagggac agccaccggt 3254101 ttcagatgca tgccgataaa cgtatcgcct atatcaattc cggcgtcagc ctgaatggtt 3254161 tcaacaagaa caggagactt catctgctta aacgcataag acgccatcgc tccgcccgct 3254221 tttggaacgg gcacggcaga aacggttgga agcctgaaca gcttggctgt ttctgcttcg 3254281 acgacaagcg ctctgtttaa atgctcgcag cattgaaacg ccagatggat tcccgttttt 3254341 tcccggagct cagcaagtcc gctgtagatg ctttcagcga tatctacact gcccgatgtg 3254401 ccgatccggc tgccggccac ttcgctcgtg ctgcatccaa ggacgaagag ctgatcttgt 3254461 ttcaattccg cttggtcctg aaactcagac agcatcgtct tccacgtttg tttcaactca 3254521 ttcattaaac agcaccccta caggtttttc tcttcataat cggagatttt tccaatacgc 3254581 gtttggtgtc ttcccccggt aaactcagta gtcagccaga tttttgcgat ttcccgagcc 3254641 aaaccaggtc cgatcacccg ttcacccatc gcaaggatgt ttgtgtcatt atgctccctc 3254701 gtcgccttcg cgctgaaggt atcgtgcgcc agcgcgcagc gaatcccttt tactttatta 3254761 gcggaaatgc tcatgccgat gcctgtcccg caaattaaaa tgcctctgtc aacttcgccg 3254821 ctaaccactt tttcggccac cggaaaagca taatccggat aatcgacaga gccgctgccg 3254881 cagtcacagc ccatatcaat atattcaatt tgcaattcgt ccattaactc tttgatttca 3254941 tttcgaatgt gaacgccgcc atgatccgat gcaatggcta ctttcatctg cttttcctcc 3255001 cagcgtgtgt gatgcggccc gcccgcttta ttgaccgcgc agcctgtccg ctctttgatt 3255061 cacaccatat gatgtgcttt tcactatatt ctactccttc acgcaggatt tgcaaatgac 3255121 ctgtttgcag attttctgac aacttatcta cggtcttttt tcagctgttt tgccagctgc 3255181 cgaagaagct cttcaagctc atctcgcgtt tgtttataga tgtcaattga gccgccgaac 3255241 ggatcgagga catcaccatg gctgcctgtg acatattctt ttaacgtaaa cactttatca 3255301 cgataacgtc caaattggct ggcaatgatc tgtttgtgct gatgggtcat agccagaacc 3255361 aaatcagccg attccataag ttcttcagtt aatggagaag acacatgatt aagggcaatg 3255421 tgtttttcaa acagcgcttc gactgcatga ggcgtcgctt tcccattagg tgaagcaaac 3255481 acgcctgccg agcggacatt gacattcagc ccttcccttt ctgcaattga tttaaaaagc 3255541 gcctcagcca ttgggctgcg gcacgtattt ccagtacaga caaaaataat atccatgtca 3255601 gtcacccctt atttttctct attatatatg aagaaaaaag aaacggcgac ttcgtttctt 3255661 ttattggtat attaaattgg caaaagcagc tttaatccaa acacgattaa tatgatgccc 3255721 ccgagcgctt cgctgtatgt gccaagccat gactgcactt gttttccgac cagcaggccc 3255781 agccatgtca acatcatgct gaacagcccg aacagggtaa ttgtgaggag cggatgcgag 3255841 ccgtatatcc ccaagctcaa gccgacggaa aagctgtcaa ggctgacgcc gatggcaaac 3255901 agcaataagc ccggccctgc cggtgacatg aatcgttctt ctgactgttt aaaagaggcc 3255961 ataagcattt gaaccccaag aacaaaaagc agcgccccac cgatataaac cgctaacacg 3256021 ccgaggagcc ctgacagcat gttaccggcc gccatccctg cgagaggcat gatgacgtga 3256081 aagaggccga tgatgaaacc aatatagaat atctgcttct ttctaagttt gaccatgccc 3256141 attccaaggc cgacagaaaa agcatccatc cctaaagcaa acgccatgat gcttaatgta 3256201 atcagttcgc ctataaacaa atccgacata cataaataac ccccttggac acgccccgct 3256261 tttttagcct atgcgtgtcc aaaaagggtt agaacatctg actgctttca gcgaatcact 3256321 cttcctccgg cggctttcat cagcctgttc ataatagcaa gaccgacacc tgtatccgga 3256381 aaggattccg ctataatgaa atccacctta ttctcatcaa agctgcgcaa agcatcatac 3256441 agccctgccg caacagtctc aagctgagcc cgtcttccgc agctcttcac ataatcagcg 3256501 gaataaacgc ccgctttttc ttctgtcgtc aggacaccga cccgtcttcc accctgttga 3256561 tattcttgaa tgaggtgctg aatgcgctct gggctgcctt cgcaaatggc aagaggcgct 3256621 gtcggcgcat aatgtgtata tttcatccct ggagaaatcg gcttctcgtt ttggtcgctg 3256681 agccctttat ccacatggat cggcccgatc accgcttcaa tttgttcctt cgtaatgccg 3256741 ccaggacgca agagaacagg gatgtcgtcc gcacatgaaa gcacagttga ttcgaccccg 3256801 attccggtag ggcctccatc cacaataccg gctatgcggc catccaagtc gtgagccaca 3256861 tgctccgctt ttgtgggact tggcttgcct gatagattgg cgctcggtgc tgcaatcggc 3256921 agtcccgatt cgcgaatcaa tgcaagggca agcggatgat ccggcattct aatggcaacc 3256981 gtttcaagac ctgccgttac acgaggtgaa agcgcatcag gtttgcaagg cagaatgagc 3257041 gtaagtgctc ccggccaaaa ccgtttcatc aatgttttcg ccttttccgg cgccgggccc 3257101 gttaaatcct caagctggct gatatccgca atgtggacaa tcaggggatt atcgctcggc 3257161 cgccctttcg cctcatatat ttttttgacg gcatccgtat tttttgcgtt tgcgcctagg 3257221 ccatatactg tttctgtcgg aaaggcaacg acctcatttt ctcggagcaa agcggctgct 3257281 tgtgcaattt gtggatcatt tgtggataac tcgtcagtta catccacaaa ccatcttttc 3257341 gttttcattt ctgaccaaac tccttattca caacaataaa acgattgttt tacgcgtgta 3257401 atccttttga aagtataaaa gatgtcctgt aataaaacaa gcgttatcca caaattgtgg 3257461 acaacgctaa taaagaagtg gataagtatg tgtataaact gcacttatcc agacgctttt 3257521 ttcatcaaaa cggctccttc tgtttgccgc gattcacaga agtgatcaga agaaaacagc 3257581 tcctccggta cactctcagc tctttcaaaa cccatggccg tcagaaagtc cgcagaggaa 3257641 tgctgatttg ctactaggta cacggttttg atctgatgct tttcgcacag cacctccatg 3257701 ctttgaaaaa gcgtgacgat gtggccttgg tgaagcttgt ccgatatgac aagtgatcgc 3257761 agcagcccct ggtcacagct tattttttca ataccgaggc atccggcaat gtttttctca 3257821 ctgtcctcca gcataagaaa ttgagtgaag ccttctttca cgccttcata gctggttttt 3257881 gcctgtttta aaaatgcctc gagcacatct ccgtcttttt cccttgccac ccgcagttga 3257941 taaaacatcc gttcaccccg tttttgcgtt ctttcttcca atctatgagg caaatctatt 3258001 tttagaccag atgattagga aaaaaggtcg gaaatccatt cgactaaaaa gaatttcact 3258061 tctgtgccgt cttctttttc ttcgttctct tcttttttgg ctttttccgc tttagcggtt 3258121 acgtcctcaa gcactttttc agtctgcttt tttgaggctt ctttatcttc ttgttctttg 3258181 acggcttccc cgttagaaaa atcaagaaag cagaggggcg ggaacagcac acaccaccag 3258241 ttggcgccgt ctccgtttcc aagcgtaatc aaaatcgctt catactcacc agcgggatat 3258301 accatgttgc cgtaaagctt tgtcggaaac gagattttgt caaaatcaac ggatatcgac 3258361 tgattcgctc cttctttctc cattgtttcc tttgcaattg ctttgatttc aggcagcttt 3258421 gaacgaatca cgcgacgcgc ttcttcaata gaagtaatat cctttaccca agttgtgatt 3258481 tctttattca ccgcgtctct tatatgacgt tttaattgct ggtcttgatc actatcgctg 3258541 tttgccagta ttctcaaacg aatcgcctga tcaggtatga ccaccggctg attttccgat 3258601 ttttgtgccg tctcttcttt tgccagccct acgagcgctc cggataataa aagaaagata 3258661 tatatacaaa tgattactgt ttttttcatc ggtccccacc gttcctctcc gtgctttgtt 3258721 tctagcccta ttatggacaa ggagagcctg ggataaacgt gcagggtgaa aaaaatctag 3258781 caagctgtta atcttattta tggtacgata gtgttttagg aggtttaaga tgaaatacaa 3258841 ttatacagtg ctgttatcag cattcacgat gtccgttctt tattcagtaa tttatattca 3258901 ttcatttatc attgccgctc tcatcacaat ggcattttat tttctgtttc cttatttgat 3258961 cttcgcactg ccgcttcaaa tcatgatgaa taaaaagccg aaacgtttca gccctttgta 3259021 tctgctgtat taccttgccg ctgcttttat tgccaacgcg atcattttcg gcatgcttca 3259081 gccttcggga caatctctgt ttcaaaatac agccttttat cttttcgctg tattaacagc 3259141 tcttatctat tggatatggg attctgtttt actgcaaaaa aaggaagcct aagaggcttc 3259201 cttttttatt aaaacaaaat cgtcagtaaa taacatagaa tggaaggtat cgccgcaaca 3259261 aagaaagcgg ccgccatttt catgcgagat gtacggcctt ctttggtttc tgaatggtag 3259321 tttgcccgct gatcgcttcc gcttacagcc aaacccgatg taatgatcgc gagccccact 3259381 aaaacgagag acgcaacgcc aaaaatcgct tcatatgaaa gagcctgcgg aaaaatggtg 3259441 ccaatcatgc tctcaatcgc aatgagcagg attcctgctg tcagggcctt tttcatgttt 3259501 acatcccctt tgctggtgtt aaacagcttg atccattcac tcgccagcaa gctgcttatt 3259561 tatttttatg aatcagagcg catatggttc tgtcttttcc attaatatct ttcagcactt 3259621 ccacttccgc ccccttaaac gccttgagga tcaggtcttt gaccgccgct ccctgtttcc 3259681 agccgatttc aaaaacgaca aatactttat ccttcataac aagcggaatg tcttccataa 3259741 accgcttata aaatttcagc ccgtctccgc catcggtgag tgcgtgcagc ggctcatgaa 3259801 aacggacaat ttccgataaa tcagccattt cttcctctga aatatatggc gggtttgaga 3259861 caatgatatc cgcttttttt cccgccttaa taaaaggctc aagcagatcg ccctgataaa 3259921 agcgcacatt cgctccgagt ttttctgcat tggcagaggc gacttgcagc gcctctttcg 3259981 aaatatcgac cgccgacaca gaaaagcttt ggttttcaag cgcaagcgtg acggctattg 3260041 cgccgctccc tgtaccaacg tcaacaactt cgagcttgcc gtcttcagaa aaaacactcc 3260101 gatatttttc aagcaaatga aagacaactt cttcagtttc cggccgcggg atcagcacat 3260161 catcattcac cataaattcc cgtccataaa aaaactcttt tcctataatg tattgaaccg 3260221 gcacgccctc tttatgcatc tcaacgtgac gcttaaagcg atacagttcg tcttcaccaa 3260281 tcggttcctg taagcttgcg agcagcttgc ttctctccat tccggtatca taaagcaata 3260341 ggagctcggc cgcattttct tctcttcccg cttcggttaa ataagaagaa gcccatttca 3260401 gggcttcgaa tatcgtcttc atcttaacct tccgactgct gaagcttgct tgcctgatct 3260461 tcaacaatca gcgcttcaac cacttcgtca agttttcctt caagaatctg atcaagcttt 3260521 tgaatcgtca aaccgattct gtgatccgtc acacggtttt gcgggaagtt gtatgtgcgg 3260581 atacgttcag agcggtcacc agatccgact gctgatttcc gtgtttgatc atattcagcc 3260641 tgggcttcct gctgaaattt atcatagatt ctggcacgga gaaccttcat tgctttttct 3260701 ttgttcttaa tttgagattt ttcatcctgg catgatacaa caacacctgt cggcaagtga 3260761 gtcagacgaa ccgcagacat tgttgtgtta acgctttgtc cgcccggtcc gcttgaagca 3260821 aatgtatcga cacggatatc cttctcatgg atgtcgacct ctacctcttc tgcctcagga 3260881 agacatgcca ctgttgcagt ggatgtatgg atgcgtccgc ctgattctgt ttccggaaca 3260941 cgctgtacgc ggtgggcgcc gttttcatat ttgagtttag aatacgcgcc gcttcctgta 3261001 atcataaaga tgatctcttt gtagccgccc gttccggtta cattcgcttc catgacctct 3261061 gttttccagc cctgaagctc agcataacgg gaatacattc tgtacagatt gcccgcgaat 3261121 aaagcggctt cctcgcctcc cgcagccccg cggatctcca tgataacgtt tttgtcgtca 3261181 ttaggatctt tcgggatcag gagcaccttc agccgttctg acagtgtttc cgtttccttc 3261241 tgaagttcag aaatctcttc cttcaccatg tcgcgcatct cagcatccag cttctcttca 3261301 agcatcgctt ttgcatcagc cagctgttct gacgcatctc tgtattgtct atatacgtca 3261361 actgtttctt gtatatcaga ttgctctttt gaatattctc ttagcttttt cggatcgttg 3261421 actacttctg gatcgctcaa aagctcattt aatttctcgt atcgttcttc aattgatttt 3261481 aaacggtcta acacggtctt cacctctgtt ttcctgtgcg taacattctc attatagtat 3261541 agtgattaac cccagtcaaa agcatttcaa tcccagctgg aaaagctccc tctgctatac 3261601 tggaattcga ggagggatga tgttgctgaa atccatacat catattgcaa tcatatgttc 3261661 agattacgaa aagtcgaaag ctttctacgt acataagctt ggttttcagg tgattcaaga 3261721 aacgtaccgc gaagagcgcg gctcctataa gcttgatttg tcgcttaacg gctcgtatgt 3261781 cattgagctg ttctcgtttc ccgatccgcc cgaacgacaa acccggcctg aagccgcagg 3261841 cctgcgccac ctcgccttta cagtcggcag cttggataaa gctgttcaag agcttcatga 3261901 aaaaggaatc gaaacagagc caatcagaac agatccgctg accggcaagc gtttcacctt 3261961 cttttttgat cctgaccagc ttccattaga actgtatgaa caataacagt ttttgaagaa 3262021 aaaaaggaga tacccacttt ctttgccgaa tcttttcttg ttttgtctaa cgggaaggga 3262081 accgcattct atggtcgaat acctagctta aaaggaggta tgggatcatg aatacaaata 3262141 tggtagcaag tgaactcggc gtctccgcaa agacggtgca gcggtgggtg aagcagctga 3262201 atcttccggc cgaacgcaat gagctcggac actattcgtt cacggcagaa gacgtgaagg 3262261 ttctaaaatc cgttcaaaaa caaatctctg aaggcacggc gattcaggat attcatctgc 3262321 cgaaaagcgc taaaaagcgc acaggcttcc ttgtccaaaa aacaagtagc gacacagaac 3262381 gaagaatcga gcagcttgaa caaaagctgg acaccctttt acagcaaagg caggacgaaa 3262441 gcgaattgat ggcaaggatg tcggaactgg aacgccagct gaaacaaaaa gccgatgaag 3262501 gtgtatctta ccagctgctt cagcaccgca gagaaatcga tgatattctt gcagatctgc 3262561 aatcactgac ctcacaaatg aaagaattca ccgctcattc gatccccgag actgctgctg 3262621 cttctgaaaa aaccaaaaca agaaaaaaac cgctgctgtc actgttcaaa tttcaaacct 3262681 aaagcaaaaa gctcccttaa agggagcttt ttttgttacg cagtaagcgc gataatgatt 3262741 ggaagtgaaa tcaatgacag aatcgcactg accacaaacg cagttgcagt ttcttcttct 3262801 tgtttctcga aacgagtcgc aatcatggct gcaacggcag aaccagggaa tgcaacaaga 3262861 aggattgctt ttgttgtttg gtcagctgga agtccgatag caagagcaat caggaacatt 3262921 aacgcaggct gaaccgcaac ttttagtaac gcaataccga tagccggcat actgagttta 3262981 attttacgaa taccaacggt aacaccaaca gcgaagagag caacaccaga tgttgtgctt 3263041 ccaagctgat caagcatttt aacacccagc tcaggaagag tgaaattgaa aaccagcacc 3263101 aagatcatac tgattaacgg agcagctgca agcggctcac aaagaccatg caggattgat 3263161 tttcctgtca tcttccagaa gctgtcgcca ctctcttcgt ttttcttaga agactcacca 3263221 acagtagcga taatgatcgc gagcggatca agaatcgcgt taaccacgat acctgtgacc 3263281 gcgatcggaa tcgcaacttc attcgctccg aataagcttc ccaataccgg gatacccata 3263341 aatgcgaatg tcggctgtgc agagttcaaa gaaaatacag atgagttcgt taaatcatac 3263401 ttgaatataa atctgcaaac caaaagaatg atgatataga aaccaacaat cccaataatt 3263461 aaagaaatca ttaaaggtac ttgtgataaa aattcacttc tggaagttgt caaaatacca 3263521 gcgataaagt gagctggaag tgcgtatttc gttactaacg tacttacccc ttttgccgac 3263581 ttggcatcat aacttccaaa atgtcctgca aaccaaccca gcacgataac aaagaagatc 3263641 ggcgccagga ggattaagat atctaagatg ctcaaaatat tctcctccaa atcctatgtc 3263701 cgtatacttt agctttacaa aaagctttcc ctcggacaga aaaatttact cgctaattat 3263761 ttcgcgatga cttttttgta ttcaggtgtc cacattgcat caagtaccgc ttgtttcaca 3263821 tcttcaggct gacgatttgc cacgccgtct ttaattgctg cttcagcaac ggcaatcgca 3263881 acttggatag aaacctcttg aagcttatca atgcttggaa gcaatcctgc tccaggtgtt 3263941 tcaagatcaa ccatttcagc aatcgcatca gcagttgcag caaacatagc aggtgtaatg 3264001 atacgcgctt cagctacaat tgaaccaagt ccaagaccag ggaacgcgaa tgcgttgtta 3264061 gattgtccga tttcataaga aacaccgttg tattctacat tgtcaaatgg gcttcctgtt 3264121 gcaataagca cttttccgtc agtccatttg aacagatctt caggaacagc ttcagcaagg 3264181 tgagtcgggt tagacatcgg catgataacc ggacggtcta cgtgagatgc catttctttt 3264241 acaatttcct ctgtgaatgc acctgaaacc cctgaagtac caatcaagat tgttggtttc 3264301 gcttgacgaa caacttcatc gaatggaatt tgaccttttt catcgcgctt ccagtctttc 3264361 acttcatccg cattgcgaag gtaaggtttt tggaaatcaa ggatgccttc gatgtcttca 3264421 gtcagcaagc ctctgtaatc aagtgtgtag aaacgtttgt tagcttcttc ttcagataat 3264481 ccggctagca ccattgtgtc acggatttgg tcagcaatac cgataccagc agaaccagca 3264541 ccgaagataa caacacgctg atctttaata gaagcgccgg ttttcttcat agcggcaagc 3264601 acacctgcaa gtgtaatcgc gccagtacct tgaatatcat cattaaatgt caggatttca 3264661 tgattgtatt ttttcatgat gttgcgtgca tttttgttgc caaggtcttc ccagtgaaga 3264721 agcgctttag ggaagaattt caatgcagct tttacataag cgtcaatgaa agcttcgtag 3264781 cgttcacctt gaacacgttc atgcttgtta ccaatatata aaggatcgtt tagaagtttt 3264841 tcgttgttcg taccgacatc aagcacaacc gggataacac ggctagggtc aataccagct 3264901 gcagcagtgt agacagccaa tttaccgatt gcaatattaa taccgcctac accccagtca 3264961 ccgataccga gaatgctttc ggagtcagta gcaacgataa gatcaatatc gcctgctgtc 3265021 gcatgaaggt tttcaaacgc tttttcaata ccgtcaatgt tatcgattga caagtagatt 3265081 ccttgaggtc ttctatattc atggctgtat tcctgaatcg cttcaccaac tgttggcgtg 3265141 tacacaacag gaagcatttc gcgaagatgg tttttcagca atttatagaa aagaacttcg 3265201 ttacggtttg caagatcact taagtaaaca ttttgacgaa ggcggtcagg ctgcgcttgg 3265261 aattgctcgt acgcgcgttg tgcttgttga tcaagagaaa gtacagttgg cggcagaagc 3265321 ccttctaagc cgagttcttg tctttcttct agtgaaaaag caacgccttt atttaaagta 3265381 ggaatagata aaacttcttt tcctctaaga gttgtttcta agtggccttc tttcgttttt 3265441 tttatgttat tcaagcaaat ctccttcttt cttgaaatag ttaaccaagt taagtaataa 3265501 cccatctaaa atatgaccga tcatgatctt tatgcgactt tgtgacaatt attcgaacaa 3265561 tgtctcaaaa ctatttacat tacgtaagct attgtatgcc tgtcaaaatc aaaattcaag 3265621 agaagaaaat tacttaattt tttaatatac ttatttaaat tttttaattg aatattatca 3265681 gaatataaaa aaaacaccgg tgtttttagc cggtgcattc tatctttata cccatgtttt 3265741 ggactatttt ttagatttac ctgggacttc gtgatgatgt ctgcatcttg cttcatatga 3265801 ttcagctgca ccaaccaaaa tgaccggatc atcgtaagaa gcaggtttgc cgtcaatgag 3265861 gcgctgtgtt ctgctcgccg gtgatccgca aacagaacag acggcttgca gctttgtcac 3265921 actttccgca atcgccatga tattcgggac gacaccgaac ggctctcccc taaaatccat 3265981 atcaaggcct gctgctatca cacggtagcc tttatcggca agagatgata aaacctcaac 3266041 aatttcctga tcaaaaaact gcacttcatc aaccgcaacc acatctgtac tttcactgat 3266101 gtgatcccaa atgtccgcag cagacgaaat ggcatagctc gtcatcgatg ttccattatg 3266161 ggagacaaca gcagcttcgc tgtatcggtt atcaattaca ggcttaaata ccctgacttc 3266221 ctgcttggca taagttgctc tcttcactct tctgatcagc tcttcagatt tccccgagaa 3266281 catgctgccg caaatcagct caagccaccc gctttgtttc attatgtaca taggcttcgc 3266341 tcccctctct ctgccagctg tgttttagac aatataaaaa acaggcaaga ctgctgcttg 3266401 cctgttgaga aatctattat tacttaagac cgtatttttt gttaaagcga tcaacacgac 3266461 catcagcaga agcgaatttt tgacggccag tgtagaatgg gtggcattca gagcaaatct 3266521 caacgcgtac ctcttctttt actgagcctg tttcaaattc atttccgcaa gcgcatttaa 3266581 ctgttgcttt tttgaaatta ggatgaattc ctgctttcat tgtatccatc tccttccgcc 3266641 ctgaatcccg tgtggaaaca gagttattat ttcggagcat tgtccgaaac gcatatgaga 3266701 aaattatatc agtgatttac ttcttttgca aatacaattt accttcttgc agatgataga 3266761 tttgcctgtt tccattcttg attgagaata tcgaaaaatt cctggtttgt tttggttttt 3266821 ttcatttttc tcatgaactt ttctgcgaaa tcaggtgaat cagacatcgt tttgcggata 3266881 gaccataaac gatcaagatg ctctttaggc acaagcagct cttctttgcg cgttcctgaa 3266941 cggcggatat cgatggcagg gaagatgcgg cgctcggcaa gagagcggtc aagatggagc 3267001 tccatgttgc ctgttccctt gaattcttca taaatgacat catccatacg tgaacctgta 3267061 tcgaccagag ccgtagcaag gatggttaag ctgccgccct cttcgatatt tctcgcagcc 3267121 ccaaagaagc gtttcggacg gtggaacgcc gctgggtcaa tccccccgga aagcgttctt 3267181 ccacttggcg gaatcactaa gttgtaggcg cgggcaagac gtgtgatgct gtccatcagg 3267241 ataatgacgt cttttttgtg ttccacgaga cgcatcgcac gttcaagcac aagctcggcc 3267301 actttgatat ggttttccgg cacttcatca aacgttgagc tgacgacatc cccagctaca 3267361 gagcgctcga tatcggttac ttcctcaggt ctttcgtcaa ttaaaagcac gatcagctct 3267421 gcttcaggct ggttcgctgt aatgctgttg gcaatttcct tcagcaacat cgtttttccg 3267481 gctttcggcg gcgcaacaat caatccgcgc tgcccaaatc caaccggcgc catcatgtcc 3267541 ataattcttg tagacaagaa gttcggcttt gtttcaagca ccatttgacg atccggataa 3267601 agtggcgtaa gagccgggaa atgcacacgc tcttttgcag attcgggatc atccccattt 3267661 actgcttcaa cgtgcaaaag tccatagtaa cgctcatttt cttttggcgg gcgaaccttg 3267721 ccagatactt tgtctccgtt ccgcaaatcg aaacggcgga tttgtgaagc tgagatgtaa 3267781 atgtcttctg agcttggaga gtagttgatc ggtctcagga atccgaaacc ttcagactgg 3267841 atgatctcga gaacgccttc cataaacagc agatcttcct gttctgcatt cgctttcaga 3267901 atggcgaaaa tgagttcttt ttttgtcagt ttgctgtaat aggagatttt ataatgtctt 3267961 gcaagttcat aaagctcttt caatttcata ttttccaaag aggaaataga tacgtctttc 3268021 ataaaaacac cacgcttttc atagtcaata tcttactctg aacatgtcat ctgctgcttt 3268081 tgcacaacat ccgccaaagc acattctttt tttaacataa aggaacttct atcggtaaca 3268141 cttccaccca tgatcggcgc ttttgttaaa aggattgtct taatgagttt tgaaggaagc 3268201 gaggacaaaa acatgagaag atcaatactt atatcgtctg tatgcggtag aaattgaaac 3268261 tttcctagtg cttaaaagaa ggtattacgc agtaaaattc gcagcactct ttatttttac 3268321 cttatttcaa aaaattattc aactgaaata aggttttgac acggaattga tagagttgac 3268381 gcttttctgc aaaagttaaa gcgggctcac acccgctttt tctgtttgtt atggacggat 3268441 tacaagattt ggtttctttt tcaagctgtg tctgccgtca acgaaacgaa cagtgcccga 3268501 ttttgcacgg ataactaagc tttcagttgt accgacagag cctttgaatt gaactccttt 3268561 taacagctcg ccgtcagtaa cccctgtagc tgcaaaaatc gcgtcatcac ccttcacaag 3268621 gtcttccatg cgaagcactt tgcttaaatc aaggcccatt ttgtgacagc gagtgatttc 3268681 ttcttcgctt tgcggaagaa gtttaccaat gatttctccg ccgagtgctt ttagcgcaac 3268741 agcggaaagc acaccctcag gagcgccgcc tgatccgaac aggatatcaa cgcccgtgtg 3268801 gtcgaaagcc gtgttgatgg cgcctgcgac atcgccgtca ttgatcaatt tgattctggc 3268861 gccggcctca cgaagctcgg aaatgatttt tgcgtgtctt tcacggttta aaattgtggc 3268921 aacgacgtcc tcaacgtcct tgtttttcgc ttttgccacc gctttaaggt tgtcaatgac 3268981 aggtgcttcg atgtcaatgc agcccaccgc ttccggaccg actgcgattt tttgcatata 3269041 catgtcagga gcattcagaa gcgtgccatg gtctgcgacc gcgataaccg tcagcgcgtt 3269101 ccagccgccg cttgctaaga tgtttgtgcc ttcaagaggg tcaactgcga catcaacgcg 3269161 agggccgtac ccgtttccga gtttttcccc gatatacagc attggcgctt cgtccatttc 3269221 cccttcaccg attacaacgg tccctttcat cggcactgta tcaaaaacgt ctctcattgc 3269281 acttgttgcc gcttcatcag cctcatcttt ttttccccgg cccatccatc ttgctgatgc 3269341 caatgccgca gcttctgtca cacgtaccaa ttccattgat aaacttcttt ccatttcaac 3269401 acgatctcct ctcacaagaa accattatga attttgaagc tgttctattt cttcgtcagt 3269461 cattctttca cgccaaattg tcgctccaag cccctcaagc ttcttctcaa ggctgctgta 3269521 tcctcggtca atatgctcca gtcccgtaat ttccgtgacg ccatcagcca tcagtccggc 3269581 taccaccaag caggctccgg cacgcagatc actcgccttc acttttgcgc cttgaagctc 3269641 gacaggacct gtgatgatgg cagatctgcc ttctactttc atattggcac ccattcgtct 3269701 cagctcatca atgtgcttga atcttgccga gtagatggtg tctgtgacga cactcgtccc 3269761 tttcgccctt gtcaggagcg ccgtcatcgg ctgctgtaaa tcagtcggaa accccgggta 3269821 tacgagggtt ttgacgtcaa ccggctttaa gttcttctgc ccgccgacaa tgaggagctg 3269881 gtcgtcgctt gtttcgatat gatagcccat ttctctcagc tttgccgtta acgactcaag 3269941 atgagtaggg atgacgttat cgataatgac ttccttgccc attgcagccc ctgcaatcat 3270001 aaatgtcccg gcttcaattc tgtccggaat gatcgtatgc ttgcagccgt gcagttcctt 3270061 cacgccgtcg attcgaatca cattggtgcc cgcacctttg attttggcgc ccatgctggt 3270121 aagcaatgtc gcgacgtcaa tgatctcagg ctccttggca gcgttttcga tgatcgtttt 3270181 cccttctgcc aaaacagcgg cgagcataat gttaatcgtt gccccaacgc ttacgacatc 3270241 taaataaatc cgtgcgcctc tcagcctttc agctcgcaaa taaatggcgc cttgttcatt 3270301 ggttacttca gctccgagtg cttcaaagcc tttgatatgc tgatcaatcg gacggggccc 3270361 taagtgacag ccgccaggca atccaatgac cgcctgcttg aagcggccga gcatcgcccc 3270421 cattaaataa tatgacgcgc gaagcttttt tactttcccg ttaggaagcg gcatgctgat 3270481 catcgacgta gggtcaacaa ccatttcccc attctcaaaa tgcacgttgc cgccgatttc 3270541 ctttaacagg tcacgcagcg tttcaatatc tgaaatctct ggaagccctt caattgtcac 3270601 ctcggaattt gccaaaatgg ttgcaggtat taacgcaaca gcgctgtttt tagcgccgct 3270661 gatatgtact gtaccgttta acgagtcacc gccggcaata ttcaactttt ccatgatagt 3270721 ctccttccat aagaagatag ctgcggagct aaataaaatg tcattttatt ctgtctctgc 3270781 aaataaagct catgtccaaa atctagccaa ttcgaagaga aagaatacaa cacattgtaa 3270841 aatatcagga agaaaatagc gaagctttgg ggggtacagg tttcaaaaga tgcacagaga 3270901 cccgccggct cgagagacat cgtcgtcatc cggcaaaagc agtacgcata cccttcattc 3270961 cgatatcagc ttctgcagcc caatgattcc ttctctgtaa agcggcgtca gcatctgaag 3271021 atccgctgta tcaggtcggt gaaatacaaa ggccgcggca aacaggcata aagctgtttg 3271081 ccgccccttt cattatttgt tccagtctgc caggaattgt tcgattcctt tgtctgttaa 3271141 cgggtgttta gtgagcgcat gaatgacttt cagcggcatt gtgccgatat gagcccctct 3271201 aagagcagct tctgtcacgt gctgcggatg gcggattgac gctgcaatga tttgcgtgtc 3271261 aaggccgtga atgtcaaaaa tctgtttaac ttctgaaatc aggtcaagcc cgttgtggcc 3271321 gatgtcatct aaacgtccca ggaatggaga tacatatgtt gcccccgctc tggcagcaag 3271381 aagcgcctgg ttggcattga agatcaatgt aacgtttgtt ttgatgccta agtcagtaag 3271441 tgctcttacc gcttttaaac cgtcagacgt cattgggatt ttcaccgtaa tgttcggagc 3271501 gatcttcgcc agttcttttc cttcctcgat catttcctca gctttcaaag aaataacctc 3271561 tgcgcttaca gaccctttca cgacgtctgt gatctcgcga agacggtcgt ggaatgatac 3271621 gttagcttcc tttgctacta aactaggatt cgtcgttaca ccggcgagaa ttcctaattc 3271681 attcgcttct ctaatttcat cgatattggc tgtatcaaca aagaataaca ttttcaaaaa 3271741 gcctccctga ttaagaaatt ttctgaactg cgaatatgat tgcgctttct aaagatagac 3271801 ggaaaaccgc ctgtcaagct gtcaggcggc tataaaaagt tccaattgaa ttaagcttgg 3271861 tttgaagaac caaattcacg cattttaccg ataactgttt ctttgatcgc ttcacgagct 3271921 ggtccaaggt atttacgtgg atcgtactcg tcaggcttag ctgccaatgt ttcgcgaaca 3271981 gcttttgcag aagaaatttg gttttcagta ttcacgttga ttttagctgt accaagtgaa 3272041 attgattttt tgatgtcagc agtcggaatt ccagtaccgc cgtgaagaac tagcggaagg 3272101 ccagttgatt ttccgatctc ttccatttct ttgaagccaa ggtttggctc acctttgtaa 3272161 gggccgtgaa cagaacctaa tgcaggtgca aggcagtcga tgccagtgcg ctcaacaagc 3272221 tcttggcact ctttaggatc agcgtagatt acgccttcag cgataacgtc atcttcttgt 3272281 ccgcctactg ttccaagctc agcttctaca gatactccgt ggaaatgagc aagctcaaca 3272341 actttagcag ttgttgctac gttttcttca aatggatggt gagaagcgtc gatcattaca 3272401 gatgtgaaac ctgcatgaat cgctttcgca caagattcaa agcttgaacc gtggtctaag 3272461 tgaatcgcaa caggaactgt cactttgtac tcttccataa gtgcttttac catagcaacg 3272521 actgttttga agccgcccat gtagcgtccc gcaccttcgg aaacaccaag gatcactgga 3272581 gatttttctt cttcagctgc ttgtaaaatc gcttgagtaa actcaaggtt gtttaagtta 3272641 aattgtccta cagcgtaccc tttttcttta gctgtattca acatttccgt catagaaact 3272701 aaaggcatgt cgaatgtcct ccttatgtag cctgattgtc ttctagcgaa aaaagctttc 3272761 caccctagca tgacccatat attgctgtca tatgtaaata ctcagatcgc tttttctcca 3272821 taactaggat accaactttt cgacaaatcg gcaacataat gacatgattc atttgtttct 3272881 tctttttgtc agttagactt caggggcaga tattttttga cggcgtctct gatttcgtcg 3272941 atgtcaaacg gcttggcaaa gtgcgtcaga gcgcccaatt ccttcgattc ctggatcatg 3273001 tcgagctctc cgtatgccgt catgataatg acccggatgt tttcgtcaat gaccttcatc 3273061 cgttttaaga tttcgattcc gtccatgccg ggaattttca tgtccaacag cacaaggtcg 3273121 ggccgttctt ttgtcacaat gtcaagcgcc tgcaggccgt tcgcagcctg aaacgtctgg 3273181 tagccttctt tattgaacac ttcatttagc aaaatacgaa tgccgtattg atcatcaacg 3273241 attaaaattt tttcattcat cattttacac cccaatatta tgattttcgt caaaagtaag 3273301 cagtattgta tgtattctgt ttgattttcc tatttccttt aattataata gtctacttta 3273361 cgacattttc tgagcatttt ctcttttgtt gtatactgat attgtacgtt ataaaggagg 3273421 attcacttat gttgaaaata ttcacgacgc agttaacagg tattttttcc cgcattcagg 3273481 ataaggaatc tgacgcgatt gaagatgggg cgcggctgct tgctcaagcg gtgatcagcg 3273541 ggcattccat ttatttatac ggagcgaatg agcttcaggg cgtcttttat gaggccaccg 3273601 aaagcaaaga acccttccca tctgtcaaag cctttccaga aaacgctgag gaagtgacag 3273661 aaagcgacag ggtgctgatg ttttgctcag ggacgggcac agccgaagaa caggagctcg 3273721 caaaagagct ttatgaaaaa ggtgcgggag tcgtatgcgt atcgcccgca gccaaagaca 3273781 gtgcgggaat agaacagtat tgtgatgtgc atattgattc taaattaaaa atgccgcttg 3273841 ttcccgatga agacggcacc cgttacgggt ttccctcttt aatgacagca ctgtatgtct 3273901 atcacgcttt atcgtttaca ctaaaagaaa ttctgcaaga gtatgcataa tatcttattg 3273961 tacatgctgg aacttgccgg aaacaaataa aaaagacttg cccgcttttg acaaacggca 3274021 agtctttttt attacttctg atttgcagct tcgacagacg ctccgataaa gcctttgaat 3274081 agaggctgag gtcttgtcgg tcttgacttg aactctgggt ggaactgaga agccacgaac 3274141 caagggtggt ctttcagctc gatgatttca acaaggcgtc catcagggct tgtgcctgag 3274201 aatacgaagc cttgctcttc catttgctgt ctgaattcat tgttaaactc atagcggtgg 3274261 cggtggcgct cgtacaccac ttcatcctga tacacttcaa aggctttcgt gccttcttca 3274321 agcttacaag ggtaaaggcc gagacgaagc gttcccccaa gatcctcaac atccttttgt 3274381 tcaggaagaa gatcaatgat cgggtattga gttgacggat caatttccgc tgagtgagcg 3274441 ccttttaagc ccaatacgtt tcgtgcgtat tcaatagacg ccacctgcat gcccaagcaa 3274501 atgcccaaga acggaatgtt gttttcgcgc gcgtattttg tcgcgacgat tttcccttca 3274561 acaccgcggt ctccgaatcc gcccggcaca atgatgccgt ctgttccgct tgtgagttct 3274621 gcgatattgt tttctgtcac ttcttccgcg ttgatccact tcacttttac atctgtgtca 3274681 aacgcatagc ccgcatggcg gagagactcg acaacagaaa tgtatgcgtc aggaagctca 3274741 acgtatttgc cgacaaggcc gattgtaatc gtttgagaca ggttgctgac tttgttaaca 3274801 agctctttcc actcggacat ttccgcttct ttgcatgcca atttcatgtg ctcgcaaaca 3274861 agcttatcaa gcccttgttt ttgaagctcc agcggaatgg agtaaaggtt gtccgcatct 3274921 tcacattcaa taaccgcttt tgtatcgatg tcgcagaaaa gcgcgatttt atctttcata 3274981 tcttgagaaa tcggcatttc tgtacgaacg acgatgatgt ttggctgaat gcccaagctg 3275041 cgcaattctt ttacgctgtg ctgtgtcggt tttgttttta attcgccagc agctttaatg 3275101 taaggcacga gcgtacagtg gatgtacatt acgttttcac ggccgatgtc gctcttcatt 3275161 tggcggatcg cttcaaggaa tggcagtgat tcgatgtctc cgacagtacc gccgatttct 3275221 gtaatgacaa catctgcgtt tgtctctttc cctgcgcggt aaacacggtc tttcaattcg 3275281 tttgtgatgt gcggaatgac ctgtacggtt cctccaaggt aatctccgcg gcgttctttt 3275341 ttaagaactg ttgaatagat tttacctgtt gtcacgttgc tgaatttatt caggttaatg 3275401 tcgataaaac gctcatagtg accaaggtcc aagtctgttt cagcgccgtc atccgttacg 3275461 aatacttcac cgtgctggta cgggctcatt gttcccgggt caacgttgat gtatggatcg 3275521 aatttttgaa tcgtcacgtt cagtccgcgg tttttcagca aacgccctaa tgaagctgct 3275581 acaataccct ttccaagtga ggatacaact cccccggtta caaaaatata tttcgtcatt 3275641 tcgtttgctc ctctcttcgc tcttagctac atttttaaaa tgtactattt tataaaaaat 3275701 catttagcct tttaaatgat ttataagaaa aatgaggggt gaaaataaga aagctccctt 3275761 tcaatttctt gaaagggagc ataacgtact atgttctctc ttcgtttttg aagagcccaa 3275821 aatacatact acatagttcg actatgaaag tcaagatcgt tttgaagatg aaatctgata 3275881 ctatttaatt tcctcttctt catcatcata gtcttcatca tcttcatcaa taatatcttc 3275941 ttcgatctca agatcatcgt cgtcttcatc aagatcttct tcgtcaaaat cgtcggcttc 3276001 aagatcgagt tcttcctcaa cttcatccaa atcaaggtcg tcttcgtcga tctcttcaaa 3276061 ctcgtcaaga tcaagatctt cttcgactgc tttcttcgct tttttctttt tcgccttgac 3276121 tgtcggctga gtttcttcat caagctgatc ataaggatac cagctgcgaa gcccccacgt 3276181 ctggtcagaa agcgccagga agcggccgtc aatgtttaaa tctgtataaa attgagcaat 3276241 gcggtctcca agctcttctt ttttcacgcc gagcaaagat gcgatttcat ttaaaagctc 3276301 ctgaaaagga actggttttt tatgttcttc aaataattcg tgagcgattt caactaaagc 3276361 catttccttt agctcttcct gtgaatattg tttgataccc aaggtcggac actccctttc 3276421 tattacttat atgtatctgt tttatcaata atgaaagcga ttttgtatcg ttcttataca 3276481 aaccatacct ctcattataa acaaaataaa acagaatatg ctacccttaa cagcgttaat 3276541 ttaaataatt ttacaagagt gatccgactg agagatgttt tccgttaatc cgcgagcatt 3276601 ctggagatga ccagtctttg aatttcttga gtgccttcat agatttgcgt gatttttgca 3276661 tcacgcatat agcgttctac cggataatct tttgtatagc cgtagccgcc gaaaatctgc 3276721 acggcttcgg tcgttacctt catcgccgta tccccagcca tcagtttgga catggcggaa 3276781 gcttttccat atggaaggcc cgatgattct aaccatgcag cctgataggt cagtagcctt 3276841 gaagcttcta tcattgtcgc catatccgcg agtttaaaag cgatgccctg ctgctcggcg 3276901 atcgattttc cgaattgctt tcgctctttt gcatattgaa gcgccgcatc aagcgctcct 3276961 tgggcgatgc ctacagcttg tgcagctatg ccgtttctgc ctccgtcaag cgtcttcatc 3277021 gcgattttga agccttctcc ttcttctccg agacgctttg atgcgggcac tacacaatct 3277081 tcgaacatga tttccgttgt cggtgaagaa cggatgccca gcttcttttc tttcttgcct 3277141 gtaaaaaatc cttcaaaatc cttttctact ataaaagcgg taacgccttt tttctttttc 3277201 tcgggatcgg tgacggcaaa aacaatgtaa atatcagcaa cgccgccgtt tgtgataaac 3277261 actttggaac catttaacac atagtcatcg ccgattcgtt cagcagttgt tttcatgctg 3277321 ccggcgtcag agccagaccc tgcttcggtc aaagcgaatg cgccgatttt ctctccgaga 3277381 gccagctgtg ttaagtactc tgtcttctgt tcctctgtcc caaaggcaaa cagcggccag 3277441 ctgcaaagag agatatgggc ggaaagcgtc acaccggtgg aggcgcacac ttttgacagc 3277501 tcttccaccg cgatgacgta ggctaaatag tcacttccaa ttccgccgta atcttcaggc 3277561 catggaattc ccgtcaggcc cagatttgcc atttcccgaa acagctcgcg atcgaagcgt 3277621 tcttgttcgt cccgttcagc cgctgtcggg gccacctcat gcttcgcaaa atcgcgcacc 3277681 aattttcgta tcatctcatg ttcttctgat aatgaaaaat tcattgcttc tcccccattt 3277741 tcagatcagc gcctaaaacg gattgagcca gaagctcgac gacgtcgtac gttttgactt 3277801 ggtcttcggc ttccttcgcc tttgtgccgt ccccaagcat cgtgagacaa tacggacagc 3277861 cagaactgat caccgatggg ttgactgcga gcgcttgctc tgtcctggcg acgttaatcc 3277921 tgttgcctgt ttcttcctcc atccacatta atcccccgcc ggctccgcag cacatgccgg 3277981 tttcccggct tctctccatt tcaacaagct gcacgcccgg aatggctttc aaaatctctc 3278041 tcggcggatc atagacttca ttgtaccggc ccaaatagca cgaatcatgg aaggtaatcg 3278101 tctcatgaag cgggtgctgc ggtcttaatt ttccgttttt cacaagctcg gccagcactt 3278161 ctgtatgatg ataaacctcg ccttcaaatc cgaaatccgg atattcgttt ttaaataaat 3278221 tgtatgcatg gggatcgatc gtaacgattt ttttgacatc atttttttca aattcagaaa 3278281 tattcttctc agccagctct tggaacaaaa attcatttcc gaggcggcgc ggcgtgtctc 3278341 ctgaattttt ttctttattg ccgagaatcg cgaaggacac gcccgcgtga ttgagcagct 3278401 tggcaaagga aattgcgatt ttctggcttc tgttgtcgta agaccccatg gagcctaccc 3278461 agaaaaggta ctcaaattct tttccttctt ttttcatttc ttttacagtc ggaatctcag 3278521 catccggcgc ctcgtcacgc caattttcac gttccttgcg gttgagtccc cacggattcc 3278581 cttgccgctc aatacttgtc attgcgcgct gggcgtcact gtccattttt ccttctgtca 3278641 gtacgaggta gcggcggagg tcgatgattt tatccacgtg ctcattcatg accgggcatt 3278701 gatcctcaca gttccggcaa gtggtgcatg cccaaatttc ttcctctgtg atgacgtcgc 3278761 cgatcaagct tggattgtaa tcaagcgccg ctgcggcttc ctgcgatccg ctgcccgctg 3278821 acgccgcagc cagctgattg cctctcgtat gccgaaacgc tgctgcgggc acccatgggg 3278881 agcgcgaggt gacggcagcg cctttttccg tgagatggtc tctgagacgc aaaatcaagt 3278941 ccatcggaga aagcattttt ccggtgcctg ttgcaggaca catattggta cagcggccgc 3279001 actcgacaca cgcgtataga tcaagcagct gagactgtct gaaatcctca atttttcccg 3279061 ctccgtagct ttctttcgtt tcgtcggtaa aatcaatttt ttcaagtttt ccggcagatt 3279121 ccattcgatt gaaaaagacg tttgccgggc cggcgattaa atgggcatgc tttgactgag 3279181 gcacgtacac taaaaagcta agcaagaata ggagatggat ccaccatgcg atatagaaaa 3279241 tcaccgccgc gcctgttttc ccgacaccgc taagcataaa cgcaatacct gaggcaattg 3279301 gctcgctcca agaaagccca tgctcatgcc aaatcagatt catcccgttc ccaagcagaa 3279361 cggtcagcat taatcctccg ataaaaatga gaacgagtcc ggctttgaaa ccgcgtttca 3279421 gcctcacgag cttttcgata taacgtctgt agaatgccca cccaacagca attaaaatga 3279481 gaaacgtaac aatttcctga aaaaaggtga aggcgggata gaccgggcca agcgacagat 3279541 tccggccggg agccagtcct ttgatgataa agtcaattgc tccgaactga accaatataa 3279601 atccgtagaa aaacatgacg tgaatgattc cgcttttctt gtccttgagc agttttttct 3279661 gtccgaatac attcacccat atggcgtgaa gccgttcctt gaaccgttga tcaaattgtt 3279721 ctttctggcc gagcttgatg taggccagtc tcgttttgac caagtaaaca aacaaataga 3279781 cagcgtaagc ggttacaatc agaaataata atgcatttgc gatgagaaag ccgctcattc 3279841 caattccccc tttttactga taaagaccgc gatcccctac ccccgaatct gtataagatt 3279901 atctttatga taaataatga atgagtgttc agtcaataat taaattcctg ctgttcgggc 3279961 acactacctt tactacggaa aggagtgccg gtatgaaggt atttatcgtg attatgatca 3280021 ttgtcgttat tttctttgcc ttgattctgc ttgatatctt catgggccgt gccggataca 3280081 gaaaaaaggc gtacgagcct gttttttcaa aaaagaagag tgacatcgaa ttgatccact 3280141 gcggcgctga tctcgttgag cggatgatga atgatattcg ccaggccgcc tcttctgttc 3280201 acatgatgtt ttttattatg aaaaatgatg aggtcagcca caatatgtat accttgctga 3280261 aaacaaaagc ccaagctggc gtatccgttt atttgcttct ggattgggcg ggctgccggg 3280321 caattaaaaa aacggcgctt cagacgatga aaaatgccgg cgtccatgtc catgtgatga 3280381 atcgtccccg ttttcctttt ttcttttttc acatgcaaaa acggaatcac cggaagatta 3280441 cggtgataga cggaaaaatc ggttatatcg gcgggtttaa tatcgccgaa gaatatcttg 3280501 gaaagaaggc gaagttcggc aattgggagg attatcatct gcgcatgatc ggagaaggcg 3280561 tacatgatct tcaaacgctt tttgcttctg atctaaaacg aaataccgga atcgaactgg 3280621 gttcggatgt ttggccaaag cttcagcaag ggactatttc tcacaagatc tatgcgaccg 3280681 acggttattc ccttgaaaac atatacttgg ccaacattgc ccaagcgaag aatcgcctta 3280741 cggtttgcac gccttattac attccatcaa aaccgcttca agaggccctt attaacgcaa 3280801 gaaaaaacgg cgtatccgtg agaatcattg taccgatgaa atcagaccat ccgctggtac 3280861 gagaagcggc ttttacgtat tattcggagc tcttggatgc cggctgtctt atttatcgtt 3280921 attatcaagg gttttatcat gtaaaagccc tcatcataga cgaccatctc agcattatcg 3280981 gaacagccaa cttcgataaa cggagcctgt tcttaaatga agaggtgaat gttgaaattg 3281041 atgacgaagc gtttacaagt gaagtctatg ccacaattga ggaggatatg aaaaagtcgg 3281101 agctgctgac gatggaggat ttcagcaagc gcacattcag gcagcgcccg gcggaatggc 3281161 tcggcagggc attatcttat ttcttataaa ggagagttcc tatgattttc agattcgggt 3281221 tcgtttcaaa tgcgatgagc ctttgggatg cgtctcccgc taaaacattg acattcgcgc 3281281 gttattcaaa gctttcaaag actgaaagaa aagaagcgct tctgactgtg acaaaagcca 3281341 atttgcgcaa tacgatgaga acccttcact atatcatcgg ccacggcatt cctttgtacc 3281401 gtttttccag ttcgattgtg ccgctggcta cgcatcccga cgtgatgtgg gattttgtaa 3281461 caccgtttca aaaagagttt cgggagattg gagagcttgt taaaacccat caactgcgaa 3281521 caagctttca tccaaatcaa ttcactctgt ttacgagccc gaaggaatcc gtcacaaaaa 3281581 atgcggtaac agatatggcg tatcactacc gcatgcttga ggccatgggc attgctgatc 3281641 gctccgttat caacattcat attggcggcg cttacggaaa taaagacacc gccactgcac 3281701 aatttcatca aaatataaaa cagctgccgc aggagatcaa agagcggatg acacttgaaa 3281761 atgatgataa aacatataca acggaagaaa cgcttcaggt ctgtgagcag gaggatgttc 3281821 cgtttgtctt tgactttcat catttttacg ccaatccaga cgatcacgcc gacctgaatg 3281881 tagcactgcc ccgcatgatc aaaacgtggg agcggatcgg ccttcagcca aaggttcact 3281941 tgtcttcccc aaaatcggag caagcgatac gcagccacgc cgattatgtt gacgccaact 3282001 ttttgctgcc actgttggaa cgctttaggc aatggggaac taatattgat ttcatgattg 3282061 aagcaaagca gaaagacaag gcgcttctcc gcttgatgga tgaattaagc tccatccgcg 3282121 gtgtcaaacg catcgggggc ggtgcgctgc aatggaagtc ataaatgtgc aaaaataggt 3282181 ttacgacttg tcagctttgg gaacttaggc tatataagac aacaatcgat ggaggagaaa 3282241 gatcatgaaa aatatcaagt ctctgaaagt agccgcacag gcctttactt taagaaattt 3282301 gattcatctt tataaaatgt gccattccgg aagccacgag gtttatattt attcaaagaa 3282361 aacgatgtgc aaaatcaaaa gcttaattga gcttgaaacg ttccgcatgg ctcataatga 3282421 aaaggaatat ctgatcgtag ttgaaggaac aaaagcatca cagctcattg aaaaattcca 3282481 aaatctcatc gagcctgctg agagagaagc gctctaactt acatacaaaa aaggatagac 3282541 atctgtctat cctttttctt atgctcttac ataatggagc tgaaccgctt gtccaaattg 3282601 ttttgtccct tttaaccgca gttttgtttc atttgttagt tcgtgaaaca gcgggatgcc 3282661 gcttcctaaa acgacgggaa taacagtgat gatgaattcg tcgatggcat cttctttcat 3282721 aaagtcattc acaagctctg ccccgccagc tatccagatg tttgagcctt tttcctgttt 3282781 caaacgggca gtgaaggctc tggctccctc attgataaac gtcacatgtt catcttgata 3282841 actgtcgggc gatcctgtaa aaacatagca ggttttatcc tgatacggga aaaccggtgt 3282901 tagcacttta acgtgctcat atgtgctccg ccctaaaatg actgtatcaa cagtctgata 3282961 aaaatcactg tagccgttgt caccttcacc ttcaaattca tccagccaat cgatgcttcc 3283021 atcttctttt gcgatcatcc cgtccaatga aacagcaatg tacagcacag tttttctttc 3283081 catgttctcc tcctatcgat gcaccatttg cccgaattgc gcttgatgca gcctgctgta 3283141 taggcctccg gcttcgatca ggtcttgatg acggccttgt tcttcaatac cgttgtttgt 3283201 gacgactaca attctgtccg cgtctttgat tgttgccagc ctgtgggcga tgacaagcgt 3283261 cgtgcgcccc tcagacaact cttgaagcgc cttttggatc gccgcttccg tctctgtatc 3283321 aagggctgag gtggcttcgt cgagaatcaa gatcgacgga tttttcaaga acatccttgc 3283381 aattgacaga cgctgttttt gcccgccgga aagcttcacg ccgcgttcgc caatcatagt 3283441 atccaaccca tcgggcatgt tatggacgag ctcttccaga tgcgcctgct tcacagcttg 3283501 ccaaatgtct tcttctgatg cgcctagtcg gccgtaggcg atattttctc taagcgtgcc 3283561 cgagaataag aaaacgtcct gctgcacgac gccaatctgc ccgcgcaacg aagaaagcgt 3283621 catgtctttt atactgatgc cgtcaatcgt aatgtcgccc tccgatgctt cataaaaacg 3283681 cggaagcaga ctgcaaagcg ttgatttccc agcacctgac ggaccgacga acgccaccgt 3283741 ttcccccgct tgaatggata ggttgatgtc attgaggaca ttgtgatggt catcatagcc 3283801 aaacgaaaca tgtttatagc ggatattgcc cttcaggccg gaaacatctt tcgaatcagg 3283861 tgagtcctga atatccggct ctgtctccat gagctccata tagcttttga aacccgcgat 3283921 ccccctcgga tacatttcga taatggcatt aattttgtca ataggcctga acagcacatt 3283981 cgtcaagagt acaaacgcca caaattcccc gtacgataag gagccgcgaa tgacaaacca 3284041 cgtcccgcac aaaaggacaa acagcgtgac aaaccgggtc agcatatagc tgattgaacc 3284101 gtttttcgcc atgattttgt aggaagaaag ctttgtgaca cgaaaacgct ggttgttgac 3284161 ggcgaagcgt tctttttcaa atgcttcatt tccgaacgcc tgcacaagcc ggatgccgcc 3284221 gatgttattt tctacacgcg cgctgaagtc tccgatatcc ttgttcagcg tggtaaatgc 3284281 tttggtcatt tttttgttga aataaagcgc tagccaaatg acgatcggca taatgataaa 3284341 cgttaataaa gcaagctgcc agttaataaa cagcatcact ccgaacgccc cgagaatggt 3284401 catgaccgca atgaataagt cttccggtcc gtgatgggcg acttcaccga tatacattaa 3284461 atcgttcgtg agcttcgaca tcagcgttcc cgtcttgttg ttgtcgtaaa atttgaacga 3284521 gagcttttgc aaatggtcaa aaagcgactt tctcatatca gtctcaatat tgataccaag 3284581 catgtgtccc cagtaggtca cgatatactg aagagccgag ctgagcgcgt acaccgcaaa 3284641 taacccgatt gaggtcgcga tgatcagtcc ccagtccctg cccggcagca aggtatcaat 3284701 aaaataattg acgatcaaag gaaaactcag ctccattaaa cctcccgcga tcgctgagaa 3284761 aaagtcgaga aagaacaacg ttttatatgg tttataatat gaaaaaaatt gccgcagcac 3284821 cctatcttcc cccaatgtat aaataactga taatatttct caattatact atacacgggc 3284881 tgttttgtaa gatcagattt cttttttctt acagaacacc tgaaaacagg cgggcaaacg 3284941 actcttttgt ccggtcagcc acacctcttt tataaaagcc gacagggctg agcttttcac 3285001 tttcctgcat atcctcttca aaatgggcct caagggttcg gatcgcttcg gcatccgtga 3285061 agaacacatt cacttcaaag ttgagctgaa agctgcgcat gtccatattc gcggtaccga 3285121 cggaggcgag atcgccatca atgatcatga ctttttgatg catgaagcct ttttggtagg 3285181 agtacacttc aatgccctca aggagcagct ccgggaaata ggacctcgac gcgtattggg 3285241 tcaaaaagct gtcgttcttc tccggcacca taacccttac ctctaccccc tttgtcgccg 3285301 ctgcttttag cgccgtgcga atggattcat tggggacaaa atagggcgtg gcgatccata 3285361 ttgatttctg cgctgaagaa atcatttcat aataaaggtc gctcatgctt tccttcatgt 3285421 cagggcctgt cgcgacaatt tgataaatgc ctcctccttc cacgggaacc ggggtattgt 3285481 actcctcttg atcaattagc acttcattgg agacatattc ccaatccagc ataaagatag 3285541 cgtggagcgt ttgcacaatt tccccctcaa gccgcaggtg tgtatctctc caaaatccga 3285601 tgtacggatc tctgctgata tattccttcc cgacatttaa tccacccaca aaaccggttt 3285661 tcccatcgat gatcacgatt ttccggtgat ttctgaaatt cagcttctgg ttgaaaaacc 3285721 cgtatttcag cggagaaaac gggacgatgt ccacccccgc ttgtttcatt ctcataatat 3285781 ctcttcttgc cagcttcatg cttcctgccg catcgtataa aaacctcacc tcgacaccct 3285841 ggcgcgcttt ctccatcata atatccatca tgccgcgtcc gagcatgtct gatttaaaca 3285901 tgtagtattc aatatgtatg taagattccg cttttctcat tgctttgaaa atgtccggga 3285961 aggtttcttc gccgtttttc agcactttga tgttgctttt cgtattgata ttcatatggg 3286021 cagccctgat ggaatatgta aagaacctct cttgattgtc cttcagccct gtcacttcgg 3286081 gcgtttcctc cttgtcaaac agcttcctga gcttttccct gttgtacatt cgttttgtct 3286141 taaacagctt tccctttaca taaagctgtc ccgaaaacag ataaaacacg tagccgacga 3286201 ttggaaaaaa gacaagaata tggatccata gcagcgtgtg ctgcgaggtg cggttttcaa 3286261 gaattaatga atagatgctg aacaaaataa tgcttatata gcaaagcaat cctccgtaaa 3286321 actcaagtct ggaaaccgga aaaaaccaaa tgacatatgc cccgatgagc atcatatata 3286381 aaaagaaaaa ttccagtctc cttttcagca tcctgattct ctccaatctg attcaattac 3286441 ctctgtatta cctctttttt ctaatcgata aaccttgtaa gtaaaaaacc tctccgccaa 3286501 aggaggagag gtttagagaa aactaactgt cacggaattc atccgcatcg tttctgcaga 3286561 aataaagcaa gactattggc aacgccgagt gacaacatga gcggcaagct gaacccgctc 3286621 agcactccgg caagcgccga aaagaaggcg gcgctgtgac tgcaaatacg gtggatagag 3286681 taaatttgat acccattctg atgagagaaa atatataaaa cgggaaattg atcagaaaga 3286741 tataaggagt tagtcaggct gaatcataat ctggctgttc cgccggttta aaatgagtaa 3286801 aatccttgat gttatttcca tatacaaaca taacaggatt cccggcagcc cagccattac 3286861 cttggcagaa aaaaccccct cttgcaaggg ggattttcac gagcgtttcc gatatacaac 3286921 gtagctgcgg gtcagatact tgagcggcag actgaacaca tgaaccaatc tcgtaaacgg 3286981 ccacaggata aaaacgacgt atcctatcac aatatgaaac ttaaaccata gcgggacact 3287041 ctccatcaaa gaggcgtcag gcctgaacaa aacgatttcc ctgaaccagg gcccgactgt 3287101 ggtccggtaa tcaaatcctt tcgaatcaat gttgagaaac gtggccgcaa cgcctgacag 3287161 catcatgaac agcagcagga ggagcgtaag gatatcggat ggcgagctcg ttttgcggat 3287221 tcttttgtca aacagccttc tgtacgtcag gatgacaagt ccggtacatg ccgcaatgcc 3287281 cgccggcaag ccagcgccaa tcgccatttt gtgatacata tgctctgaaa tgccaaggga 3287341 agcatacacg ccttctggga tcagaatccc catgacatgc ccgccgacaa cgcacagcag 3287401 tccccagtga aaaagtgtgc tgccagccgc aagttttttc ttttctaaca gctcgcttga 3287461 tttcgccgtc cagccaaatt ggtcatgctg atagcggtaa atatggccgc cgataaagat 3287521 tgtcaataca atgtatggca taatacccca gaggatctgc ccgctcatgc ctgaacagcc 3287581 ccttcaacgc tttcacgtac gccaatgttt tcaagcgcgg ccagcagcac gtgcagcagt 3287641 tcagcgtata tactgtcatt tttttcgaga cgggatgcca gctccctcac attggacaga 3287701 tatttctcaa acacgcttct cgctgcttca atttctgcag ccgcagcaaa ttccagcatc 3287761 agcggcagat aatcaggcag ctctttctct gtcggcagga aaccggattg ctcgtatgtg 3287821 ttttttaaat gcagcaattc aatgccgcgt tccctttgct cgcctgagtt aaagtaggtg 3287881 acatacatat ttgttttttt cccgaagtcg aatgtataga catagtgttc aatcagcgct 3287941 tccggagaat agctggctga cgtctcgaaa aagtgcagca gcttctcccg gatttgccgg 3288001 ttgccgattt cttggataag agccttccaa tcgggaagct cggctctcca ctcttcatcc 3288061 ggataagaga gaagacagga aagagcagag aacgtgattt gccggtctgt ggtgttcatc 3288121 ttgttacacc tcatttatca aaagttagaa acaggagccg gggccgcctg aaaatgataa 3288181 gccgcagctt ccttgttcag cgtataaatc tgatacttct tctcgatggc tgctcggaat 3288241 cacaaagcgg tcatcatatt tggcaatcgc aagcagccga tacatatctt caatttgctg 3288301 ttctgttaag ccgacactgg agatcagttc cggatcgatt gatttattcg tctggaccgc 3288361 tctcatatac tggcgcatga cagacatttt ctttaatgtt gaccgaatat gatccgtatc 3288421 accggctgtt aacagctgcg ccaaataatc tatcgggatt ctcatttggt cgatagccgg 3288481 aaaaatatct tccgccgttt gccggctgcc ttttccttca aagagattca taatcgggct 3288541 gagcggcgga atgtaccaca ccattggcag cgtgcggtac tcaggatgaa gcggcagcgc 3288601 gatcttccag tcaatgatca ttttatagat cggtgattgc tgcgcggcct ctatccattc 3288661 agccggaatg ccttgttctt ttgccagttt ggcaacctca ggatcattcg gatcaagaaa 3288721 aacgtccaat tgggaatggt agagatcctt ttcattttca acagatgccg cttcctccac 3288781 tttgtccgcg tcatatagca tgacgccgag gtagcggatt ctgccaacac acgtctcaga 3288841 gcagatggtt ggcagtcccg cctccaaacg cggaaagcag agtgtgcatt tttccgcttt 3288901 gttcgtttgc cagttaaaat agactttttt ataaggacag gatgagacgc aatatctcca 3288961 tgaacggcat gcgttttgat ccacaagcac aatgccgtcc tcctcgcgtt tgtacatggc 3289021 gccggatgga caggatgaga cgcatgccgg gttgatgcag tgctcgcaaa tacggggcaa 3289081 atacatcata aagacgtcat cgaattctgt tttgatcgat tcctccatct tttgtacgtt 3289141 gggatcttca agtcccgtaa tgtggccgcc tgcgagatcg tcctcccagt tcggtcccca 3289201 ttcgatattc atgaaatccc ccgtcaagga cgatttcggg cgtgctaccg gctggtgttt 3289261 tttctgcggg ctgttcgtta atgtttcata atcatagttc caaggttcat agtaatcatc 3289321 aattgacggc tgattcggat tatagaaaag gcctgcaagc cgattggttt tcgagcccga 3289381 tttcagctcg agctttcctt ttttcaatgt ccagccgcct ttatatttgt cctggtcctc 3289441 ccattgcttc gggtagccga tgcccggctt tgtttctaca ttattgaagt acatatattc 3289501 cgcaccggaa cggtttgtcc acgtgttttt gcaggtgacg ctgcacgtgt ggcagccgat 3289561 gcatttatcc aagttcatga ccataccgat ttgcgcttta atcttcaagc caatcgacct 3289621 ccttcagctt gcggatgacg acgttcaggt cgcgctgatt ccccgttgga ccgtaataat 3289681 taaagccgta gctgagctgg gcgtagccac cgatcatctg tgtcggcttg acgtgaatcc 3289741 ttgtcgggct gttatgggtg cctccgcggt tattcgtcag ctttgtgccg ggcacgttga 3289801 tgtggcggtc ctgggcatgg tgcataaacg ccattccttt aggaatccga tgagacaaaa 3289861 cggctctcgc gacgacaacg ccgtttcggt tgaagcattc aatccaatcg ttgtctttga 3289921 tatccgtgtc ctctgcatca tctttattca tccacacggt cggcccgccg cggaacagcg 3289981 tcagcatcgg cagagaatca aaatacatgc tgtggacaga ccatttatta tgcggcgtca 3290041 aataattgag gacgatttct tttccctctt gatcaggccg tttgctcaga aacgggcgat 3290101 gctggaggat cggtttgaat gtcgccatcg tttcaccgaa ttccatcatc agttcatgat 3290161 cgacataata ggattgtctg cctgtcagcg tccgccacgg aattaatttt tcaacattcg 3290221 ttgtaaacgg cgaatacctg cgccctcctt tttcagagcc ggtaaacgct ggagacgtga 3290281 tcaccgtttt cggctgggct gtaatttgtt cgaacgtaaa gcattcttcc tcgcgttctt 3290341 ccgccaggtc tttcagcttc aggttcgtga tgttttcaag tgattcccat gcttttactg 3290401 cgacctttcc attcgaagtg gatgataggg ttaaaatcgc ttctgcagcc tgctttgctt 3290461 cacttatatt tggacatccc tttgccacgc tgtccgaggt gatttctccc agtctctgtt 3290521 tgagtgattc atattcatcg gctattgacc agctcatccc ttttgttccg ctcggcttta 3290581 aagcaacgtt cggaccaagt gcagtcattt tatgaaaaat gtgtttgtaa tcccgttcaa 3290641 cgacttggat gttcggcatc gtttttcccg gaatggcttc acattcgcct ttgctccagt 3290701 cattgatttt gccgaatggc tgggccaatt cctgcatggt gtcgtggagc agcggtgtcg 3290761 caaccacttc tttcaccggc tccatatcga cttcttctgc cagatcggaa acggcttttg 3290821 acagcgcctt gaaaatatcc cagtctgact tcgattccca cggagccgag atcgcaggag 3290881 caaatggatg aatgaacgga tgcatatctg tgctgctgag atcgtgtttt tcataccatg 3290941 tcgccgccgg cagcacgata tcggaataca gcgccgtacc cgccattcga aaatcaagat 3291001 tgattaataa gtcgagcttt ccttccggcg cctgctcccg ccatttgatt tcttctgggc 3291061 ggatgctgtc gctgtcgtca ttcattaaac cgttcgttgt ccccagcaaa tgcttgagaa 3291121 aatattcatg cccttttcct gagcttgaga tcagatttgc ccgccataca aagagattcc 3291181 ttgggaaatt cacttcattg tcaggatctt caatcgcgaa tttcagtttt ttctcttgga 3291241 gctgtgaggc cacgtacgca cctacgtctt caggtgttgc tgcccctgct ttttcagctt 3291301 ctttatacag atcgatgcca ttttgattga aagtcgggta agacggaagc caccctagcc 3291361 gcgccgccag cacattgtaa tcagcgtggt gcttgtagcg ggatgaagca gcaatcggtg 3291421 atgccaaatc actgatcggc tggtcctcat aacgccactg atctgtcgca aagtagaaaa 3291481 atgaggtgcc attttgcagc ttgggcacgc cttcccagtc ctttgcagtt gcaatcgtct 3291541 gccacccttc agcaggtcgg agcttttcct gccccacgta atgggcccag cctccgccgt 3291601 ttacgccttg ggcgcctaca agtaaaacaa gatttaacac tgctcggtag atcgtgtcgg 3291661 agttgaacca gtggttaatg ccggccccta cgataatcat ggaccggccg tctgtatcga 3291721 tcgcattttg ggcaaactct ctggcaatct taacgacagc ttcttttttg attcctgtca 3291781 tttgttcctg ccaggcaggc gtaaacggct cagggtcatc ataggagaca gccgatcgtt 3291841 cgccgatgcc ccggttcacg ccgtagttag ccagtatcaa gtcaaacacg gtcgtgatgt 3291901 acgtttcttc accgttcagg ttcatttttt taataggaag atcccgctcg agcactttgt 3291961 ttccgtcatt tgaaaaatac gggatgcgca ccgtgccgat ttcgtcctct attcccagca 3292021 cagagagacg gggttcaatc ggttccccgg tttcttcatc aatcatgtgc aggttccatt 3292081 tctgctgccc gtcccagcgc gagcccattg tcccttgggg tatggcaaat gaacttgtct 3292141 gttcatccca aaccgcaggc ttccactgat catgctttgt cttccgcccg atgtccttcg 3292201 catgcagaaa ccgtcccgct gtgtatacgc cattttcttt tgacagagtg acgagaaatg 3292261 gaaaatcagt gtattgcttc gcgtactcaa taaaacgttc agtttcttgg ttcacgtaaa 3292321 attcctgcag aataacgtga cccatcgcca tcgcaagcgc cccgtcagtc ccttggcgaa 3292381 tactcagcca gtcatccgcg aactttgagg attccgcaaa atctggactg atcgaaatga 3292441 ccttagcgcc tttatagcgg gcctccgcca aaaaatgcgc gtcaggcgtt ctcgttaacg 3292501 gaacgttgga gccccatgtg ataatatagc cggaattgta ccaatcactg ctttccggaa 3292561 cgtccgtctg gtcaccccaa atttgcgggg atgctggagg aagatccgca taccagtcat 3292621 aaaaactgag catagggcct ccgattaacg acataaaccg ggagcctgat gcgtggctga 3292681 tcatggacat ggccggaatc ggagaaaaac cgacgtttcg gtcaggcccg tatttcatca 3292741 ctgtatacag cagagaggct gaaatcagct tcagcacctc cggccattca gcgcgcacaa 3292801 aaccgccttt ccctctcgcc tgtttatagg acttcgcttt ttcagggttt tcgacgatcg 3292861 atttccaggc ttccaatgga ttttgatgcg tctgcaatgc ctcccgccac aaattgatca 3292921 gcacaccgcg cacgtatgga tatttcacac ggagcgggct gtagatatac catgaaaaac 3292981 tggccccccg cgggcagcct ctcggttcaa aatcaggcat atccgggcct gttgatggat 3293041 aattcaaatt ttgcccttcc cacgtgacta ttccgttttt cacataaata ttccagctgc 3293101 aagaccctgt acagttgacg ccgtgggtgg agcgaacgac tttgtcgtac tgccatctgt 3293161 ttctgtatac attctcccaa tcgcgatcct cgcgggtagt ttggctatgt ttatttgaat 3293221 ggtgttcgat aggagagaaa taattcaatc tcctaaacaa cggactcctt ttctttttct 3293281 tcatgagagt tcactccttc cgagtcaggt gatgctaagt tcactataaa cagagacagc 3293341 gtgtttcctt gtgaactatg tcacacactc tgcttttttc acaaaatgtt cacacaaagg 3293401 agaaggaagg ctgcgttcag gcaggacgct tgggtcatta gctgcctttc attcaaagat 3293461 caaaaaaaac cggctctatt taagaaccgg gctcagcgtt ttcatcctgt gatgtatgca 3293521 gataccgcaa aaataattga taggaacaaa aaacattttg ctgaagcata gccaaaaagt 3293581 tcatttgcag ctgcggatga taagacatca ttttcttaaa tatgtaatat gggatgttga 3293641 gaatcagaat gtctgaagtg gcattgactg agataaaggg cgataaataa agcccgcctt 3293701 tttcatcaat cggaaacaca tcgccttttt cccacagcgc aacggttttc gacccttcag 3293761 ggagccttgt gtccataaaa cggacactgc cttttaatac aatataaaca gattgagaat 3293821 gaagaaaaga tggagactga tcacatgaac cgcggataaa cgtgccgttt ttcagcaagg 3293881 tttcgacaat ggatagaggc acttcattaa acataggaag ttgtttcaga aataataaat 3293941 agtcacactg attcatagga aaacctcctg tgctaaggat agctttagtg tagctcgact 3294001 gagcctgtac agcagtgatg tatttcacag cctgtatgat gaatgtcact tatcaggagg 3294061 gtgaatgcat ttataatgaa agaaaaaagg aggatttcga tgaaggcgct gattccgaag 3294121 cagcacgggg cgtgggcgat gctgctgatc ccatttttac tcggcatggt caagggaggc 3294181 cccgttattt ggcatattcc gctcttcctt ggttggcttt tcctatactt agcggtttat 3294241 cccgttacgc ttgccttaaa aaagaaacaa agcaaaccat atcaaaagtg gatgtgttat 3294301 tacggttttc ccacctgctg ctttttgatg atctcggtct ttcataagcc gcctctcatc 3294361 tgggtgggcg tttctttact gccgctgttt ctcatacata tgtattttgc ccgcagaaaa 3294421 aacgaacgag ccttattgaa tgatgttgca ggtgtcttgt tcttttgttc gggcgggttt 3294481 gcgagctgct ggctggggat gggaaccctt gacggctggg cttggtttat tttcttgcag 3294541 tctgctttat tttttatcgg gagttccttt tatgtgaaat cggtgatccg cgagagaaaa 3294601 aacagggcat ttgcatactg gtcatgggga tatcacctgc tgctcccctt tttatccgct 3294661 cttttcggag caggatgggc gtttctcgct tttatcccga gcagcttgcg ggcatggttt 3294721 tttcatggaa gggattggcc cgtaaaaacg attggcattc tggaaatcgt gaatgcctgc 3294781 ttctttcttg ccgtcatgtg cctgtttatc acaaggtaaa aaaacaagga caccgctgtc 3294841 cttgtttttt tcagtcaata ttgcaaatct ccagcgggca attttcacac tcaatctcac 3294901 atcgtaaata gtcccgcttg tgcaaaataa tttttccgga ttcgtctatc gaaataaccc 3294961 cttttttgcg gagatctccg agcatacgat tgacgctttc ccgtgcagcc gcgcaaaact 3295021 ttgccaaatc ctgatttgtc aggacaatgt taatcagaat gccgtcgctt cgctccactc 3295081 cgtagctgtt tgataagcgg ataagggtag aatagagcgc cccctttttg ccatgaagaa 3295141 gcagatccct gattttggac tgaatcttcc ggaggtgcgt gctcatccat ttcatgaact 3295201 caaatgtcaa agcgccgttt tggattaatt ctttttccag cttattttta ttaatgacga 3295261 gcacctcgcc atcctctagt acttttgcac tgagcatata ccttggttct tcagtgaaaa 3295321 gtgttaattc tccgacgata tcatgctttt ggcagattct aagcgtcagg tcttttccgt 3295381 cagatgtcag cttgccgatt tcaatgagtc ctgattgaat cagataaagc tcttctgcat 3295441 ccattccttc ccgaaacaaa tacgtgtgtt tttccatttt tcttttcgtg ctgatcgatt 3295501 ccagcaattc atacagatcg ctggatataa gatcactatc agatggtcga acagagagaa 3295561 aattcatgag ctcacctcga agaaagtcac gttgtgtgtt tattgtaacg tgaattgatt 3295621 tgtacccatc gagaaaaaac taacaatctt gtgaatgccc cagtgttagt tgatgctctg 3295681 gctgtttctc tccgtgtgtg ttttcattct ttcctgccaa tacatccata tgacaaggac 3295741 aaaactggct aacgccacct ctgaaagcgc cataaacccg atcgcgtact ggcctgttgc 3295801 ctgaaataca ctcgccaata tgagcggagg aaaaaagccg cctaaaccgc ccatggcaga 3295861 cacaatccca ttggcaatcc ccgcttgctt cgaaaaatag aaaggcacca gtttaaaaac 3295921 agttccgttt cctatgcctg agcagacggc cacggttaat gatccaaacg tataaaggcc 3295981 gattgtcggc gagaacgata ggataatgcc tgataatgta agcccggcaa aaacaaacat 3296041 caagatgcgg agcgggctca ttttatcagc caggaatccg cccgcaggcc tgagcagcgt 3296101 agaaaccgca ataaagccag ccgtccgcaa gccggcatct gcaggattca gcccaaaatg 3296161 ctccaccaga aagttcggca gatagatagt gaaggcgaca aaggcaccga acgtaataaa 3296221 ataaaacagg ctcagaaacc atagcacatg atttcggtaa acagctttga tttgagtctt 3296281 aacagaaact ttgaccttct tctcatgcct gtcgccaaac aatacgtgca gtaaggcaaa 3296341 gacagccagc aaaatcagat acatttgcac ggttgatttc cacccgacgg cttgagcgat 3296401 aaccggcgct gcaaatgtcg taacggctgt cccgatattt cctgcaccgt aaatcccatt 3296461 gacgacaccg tgcttttctt tcggataata tttcgggagg gaggtcaccc caatggaaaa 3296521 caccgctccc ccgatcccta agaaaaagcc gcctgcgatt aaatcaaaca gagaatccgc 3296581 gatactgatc caaaatacag gaaataaaag caggatgaag ctgaccataa acatgagccg 3296641 cgcgccaaac ctgttcgtta aataccctaa aggaatgcgg agaagcgacc cgaggatcac 3296701 aggaatcgcg gtcactaaag aaatctcacc cttgcttaaa tgaatatcta atgtgatttg 3296761 ggaaatgagt gatgaaatca gcacccaaac cataaaccct gccaccaagc ttaatgactg 3296821 taacgataat tgaatgtgtt gacggttgat catttggctt gcccctttca atgattcaat 3296881 aatcagtctt atcatacaaa aactagccaa acaggattgt gaattacatc acacgttttt 3296941 ctcataaaaa aaggacaaag cccgaagact ttgtcctttt gatcgtgatt acattttttc 3297001 cggagccgat acgccgatca gctgaagcgc attgttcagc gtaatttgcg ttgccttcat 3297061 taaagccagg cgcgcgcggc ttttctcttc attttcaggg tcgatgactt tctctgcgtt 3297121 gtagaagctg tgcagagcag aagccagatc ataaatatag ttagtgacac ggtgcggaat 3297181 tcgtttttcc gctgcttccg ccactgcctc tgggaagccg ccgatcgttt tcagcagatc 3297241 gtattctttt tctgattgaa tatggctgaa atcaagatct gccgccggtt taagcccctg 3297301 ctcttcccct tggcgaagca tgctgcaaat acgggcatgc gcgtattgtg cataatacac 3297361 agggttttcg ttagatgttg atacagcaag atctaagtca aaatccatat gggtgtctgc 3297421 acttcgcatt gcaaagaagt aacgcacggc atccaagccg acttcttcaa tcaggtcacg 3297481 catcgttacg gctttaccgg tccgtttgct cattttcatt ttctcgccgt ttttgtaaag 3297541 gtgaacgagc tgaatgattt ctacttcaag cgttcctttt tcatagccca gcgcttcgat 3297601 tgccgctttc atacgcggga tgtagccgtg gtgatcggcg ccccaaacgt tgatcagctt 3297661 atcaaagccg cggtcaagct tgtccttatg atacgcgata tcaggaagaa ggtacgtgta 3297721 cgtgccgtcc ttcttgatca atacgcggtc tttatcatcg ccgaaagtcg tggaacggaa 3297781 ccaagtcgcg ccgtcttctt catagacgtg gcctttttcg cggagcgctt caagcgcctt 3297841 gtcgattttt ccattttggt acagtgaagt ttctgaatac cacacatcaa acggcacacg 3297901 gaagttttcc aagtccttgc gaagcttttc cagctcgtat ttcaggccgt attcacggaa 3297961 aaacgcgagg cgttcacttt cctcttcgtt aacgaaacga tcaccgtatt cctcagcgag 3298021 acgctttccg atcgcaatga tatcctcacc gcggtagcca tcctccggca tcggtttttc 3298081 caatccgagt gcttcaaagt aacggacttc aacagaaagc gccagattgt tgatttggtt 3298141 tcccgcatcg ttaatgtagt attcgcggct tacatcgtaa cccgcttttg aaagcacgtt 3298201 gcacaaggaa tcgccgacag ccgccccgcg cgcatgcccg aggtgaaggt ctcccgtcgg 3298261 attcgctgat acgaattcta cctgaactcg ttcaccgttt ccgatgttcg tttccccgta 3298321 tgcttcccct gcttccagta cagacggaat cagctttgtt aaatattgat tgttcatata 3298381 gaaattgata aaacccgggc cggcgatatc cagtttttca atcgaagcct tccctttatc 3298441 aaaatgggcg acaatctctt cagcgatttg acgcggcgct ttttttgcca ctcttgccaa 3298501 ctgcatcgcc atattcgttg agtagtcgcc gtgtgtttta tctttcggtg tttctaaaac 3298561 aacattggga atctggcttt cttcagccag tcccgctttc agaacggccg ctttgatttc 3298621 ttctttcagc acgtccttca tttgttccgc aatgttcatg cgtgagttcc tccctcatac 3298681 gtgatcgtca tattatgtaa atgctcctgc tcgtctccga catgcatgtc atatgcgatg 3298741 ctgatacggc ctttttcttc atcgagatca gattgaatcg attttgtgct tgttttcagc 3298801 tcaagctcac caaatgacat tttatattta gcaattgtgg aagctcccgt tacgaaacgc 3298861 tgattcattt tgacagcgcc tgacctcatg accaggactt cgccttcgct tactttcaca 3298921 atcgttttga ctttgcctaa gtcgtgttct tcataataag atagatacac tttattttgt 3298981 tttacatagt aaaatccggt ggtgcggaat tcgatgactt cttggtttcc gtcatcctcg 3299041 atcacagact tcacatggag tgttatcggt gtctcttgct tcattctgac acgtcctttt 3299101 catcattcca ctttgacttg aatagtataa tcattcggtt tgtaaacttc aactgcttct 3299161 atcttaccat cattgctcat cagatttgaa gataaacctc ataaaaagca tttccttata 3299221 tagaagagaa aatcatatca ctaattacct ttaggaaatg ttacgagctc gctacatcgc 3299281 aatcgcagac ggacccgcgc caaccggaat caccgtcacg gctgtataat cacttgtgcg 3299341 gtacacggtc acagcattgt cgttgggctg tgccgcataa atatactgtt tgtccggcgt 3299401 tacggcgagg tcaaaggcgc cggggagaga cacgtttgca atgatcctct gtctggccgt 3299461 attaactacg tataagttat taatgagaaa cggttcacta tatggctcta gaaaataagc 3299521 tctagtacta tcgagagaaa atacaatcgt cctcagcgtt tcaaataaac ggctgaagtc 3299581 ccctcccctg cttaatggtg acaaactaat ctccgttaca cctttcggcc acagctcacc 3299641 attcaatacg tacgcaaaat ttccagcgta aggagttgta attaaactgg gaaattcaaa 3299701 tgtatctatg atactttcta ccaactgccc agtatttaca tcatatttat caaccgacca 3299761 actgcttcca ttagcggtat agacatactg tccattcgga tcaagagcaa agtctaaagc 3299821 gccgggtatc ggaatgacat caatgaccga ttgagaggcc gtgttaatca catatataga 3299881 tccggcggcc atcacgtatg cgaactcatc tgttggatca aattcgattt ttctcggccc 3299941 tcctccaaca gtaatggtat ttatgatggt taatgtttta ttatcaatca ctgagacaag 3300001 gttggtattt ccatggagga catacgtgaa tgctttatcg aaagtaacgc ctagattagt 3300061 tggcacgtca gaaaaaggga ttgtttttac aacagtgttt aaatctgcat caataaccga 3300121 aaccgtgctg tctccagtat tggcagtaaa cacatacgat tgagggtctg gtgatggcgg 3300181 taaaacaagt gtcccggcca ccgtaagcgg actgccgtag aaaggcggta caatgagcag 3300241 atcttccact gttatttgac tgaaatcagg acagcggcca gactgtgctg cataataaac 3300301 aacttgatca atctcttcag tatgaatcac agaaacagcc ccgtctcctt gtccatattg 3300361 atttcgtaca ggcgacacac tgacaagaag cgtaatggtc ccttgtactc tcacagcata 3300421 tcgaacaccg atatcttctg gttccggccc agtctggatt aagcaaggct cactgataca 3300481 ggacaaattg tctgtactcc atgtaacagc cgctgacgct tcggccgtat caaccttgaa 3300541 gccctcaggg aaatctatcg gcacttgaaa cggcgcttcc cggctaattt cctcatcaca 3300601 aaaacagaaa caattttcct gtaaagcaga aagatcattc tttttcatga tttcacgtcc 3300661 ttttagaaat gcacaacatg cagcggttaa atcgtaatgg cacccggtga aaccccaaga 3300721 gatatcacag tttcctcaga ataatcatct gtgttgtaaa caatgatgct ctgctctata 3300781 aaacgagttg catacagaaa atcgccattc ggggtaaacg catagtctgt tgctgattgc 3300841 ggaacatttc ctataacgcc tgctccattt ggactgacag aatataaatt gccagtgaag 3300901 ccgtcatata aatacacctc tgctccactc gtaaacattc gatattcccc ttcatactcc 3300961 agctcttggg tgctgctgat ggtaaacgta tttaaatcaa taaccgtcaa ataattaaaa 3301021 aagaattctt gttctaatac ataggcatac cgctccggcc aatttgtttc tatggttgat 3301081 acgataagct ctcgttcaat tgttcctgtg acttcaccgg tagttaggtc cactttttgc 3301141 actattccaa aattcagaac ataggcgaat aacccattgg gatcgattgc aacatcatat 3301201 ccttccacag gaatcgacct atccacagtt aacgtatcaa ttccaatcac ataaaccgca 3301261 gtaccggtga aaacataagc aaactcatga ttagggataa atctaatcaa tcgaggcggc 3301321 tgatccagca atatagttgc tgtcactgtt aatgtgtcat aatcgatgac agaaatcaca 3301381 ttattgttgg gatgtaagac aaacacagcg cttttatctg gcgtaatttc aatacctgcc 3301441 ggattgtacg gaagagcaat cgttgtcaca acagtatcgg tgtttgtatc aatcacagaa 3301501 actgattgat catttggatt cgctgtaaac gcgtagacgg gttccggctc cggtacaagc 3301561 acaattgtcc ccgtcaccga taaaggactg ccgtaaaacg gcggaacaac aacaaggttc 3301621 tcaatcgtga tgtcactgat atccgggcaa tcatccgatt catcggaata atagacgact 3301681 tgatcgattt ctgcattgtg aatgacggaa acagccccgt ccccttgtcc atattgattt 3301741 cggacaggtg agacactgac gagtagcgta acggttccct gcaggcgcac tgcaaattga 3301801 acaccgacct catcaggctc aggccccgtt tgaattaagc aacggtcact gacacaagaa 3301861 aggctgtctg cattccacgt cacgtttgca acagcttcag ccggatcaac gacaaaccct 3301921 tcaggtaatt caatcggtgc ttgaaacatg gcttctcggc ttgcttctcc ctcacaaaaa 3301981 cataagcact cttcttgttc tgctcctgct ttttctttaa aggaaagctt gttttttctc 3302041 attccttcac ttccttttca gacatacact gctcacgcag atataacaga atatggaagg 3302101 gtaacgtgtt tgcttgtaca aattgctgag ggtaaacgct tctttttgaa aatatatctc 3302161 caaacatgcg gtgtaacgaa agaaaaaatt gcggtttttt tgcgcttctc acaagaatgt 3302221 tgatgataaa atatgacata tatagaatta tgaagggagg gatttgcaaa cgtgacaggt 3302281 gtcatatctt cttcttccat cggagaaaag attaacgaat ggtatatgta catacgccga 3302341 ttcagcatac ccgatgcaga atatttgcga cgagaaatca agcaagagct ggatcaaatg 3302401 gaagaagatc aagaccttca tttgtactat tcactgatgg agtttcggca caacctaatg 3302461 cttgagtacc ttgaaccgtt agaaaaaatg aggattgagg aacagccgag actgtctgat 3302521 ctgctgcttg agattgataa aaaacaggct cgtttaactg gtctgcttga gtactatttt 3302581 aacttcttca gaggcatgta cgagctggac cagcgggaat atctgtcggc tattaaattt 3302641 ttcaaaaagg ccgaaagcaa gctgatattc gttaaggatc ggatagagaa agctgagttt 3302701 ttctttaaga tgtctgaatc ttattactat atgaaacaaa cgtatttttc aatggactat 3302761 gcacggcaag catatgaaat atacaaagaa catgaagctt ataatataag attgctgcag 3302821 tgtcattctt tatttgccac caatttttta gatttaaaac agtatgagga tgccatctca 3302881 cattttcaaa aagcttattc tatggcagaa gctgaaaagc agccccaatt aatggggaga 3302941 actttgtaca atatcgggct ttgtaaaaac agccaaagcc aatatgagga tgccatacct 3303001 tatttcaaaa gagcaatagc tgtttttgaa gaatcaaata ttcttccttc cttacctcaa 3303061 gcgtattttt taattacaca gatccattat aaattaggaa aaatagataa agctcatgaa 3303121 tatcatagta agggaatggc ttattcacaa aaggccggag atgtaatata tttatcagag 3303181 tttgaatttt tgaaatcttt atacttatca ggcccggatg aagaagcaat tcaaggattt 3303241 tttgattttc tcgaaagtaa aatgttgtat gctgatcttg aagatttcgc tattgatgtg 3303301 gcaaaatatt atcatgaacg taaaaatttt caaaaagctt ctgcttattt tttgaaggtg 3303361 gaacaagtaa ggcaacttat tcaaggagga gtgagtttgt atgaaattga agtctaaact 3303421 attactctct tgtctggctc taagcactgt gttcgtggca acaactattg caaatgcacc 3303481 tacacaccaa attgaagttg cacaacgagg aatgatttaa ccgccgtcca tcggcggttt 3303541 tttcgtcccc tctttaccaa agtctcccaa tccatgctat gatcttttca ataatcttga 3303601 agagagtgga aatgcagcat gtctctaaaa agtgtgagaa cccactttac tcaatggaat 3303661 cgagaaaatg atgtgacgga gttcgaaacg tcgagtgcga cagttgaaca ggcagctgag 3303721 acaatcggcg taagcctgtc tagaatcgcc aagtccctgt ccttcagagg ggaaggagat 3303781 caggtgattc tgattgtggc agccggcgat gccaagatcg acaacaaaaa gtccaggcaa 3303841 acatttggct ttaaagcaag aatgctctct cctaatgagg tgctggagca gacaggccat 3303901 gaaattggag gagtttgccc atttggattg gctcatgatc ctgaggttta tcttgatgta 3303961 tcgctgaaac ggtttcagac tgttttcccc gcatgcggca gcagaaactc cgctattgaa 3304021 ttaacaccga aagaattatc cgaattttct ttctcaaaag tgtggattga tgtttgtaaa 3304081 gactgggaat aaaaaaacat ccagacatcg tctggatgtt tacttatttc acaaacccaa 3304141 gcagcatttc acggatgatt ttgctggctg tgtttgccgt ttgctctgag tggtcgtata 3304201 ccggcgcgac ttccactaaa tcagcgccct ttacgtttac ctctgaacgc gcaatttcat 3304261 ggaccgatgc aagcagttct ttagacgtga tgccgccggc gtcaaccgtt cctgtacccg 3304321 gtgcgtgtgc agggtctaat acgtcaatgt caattgtgac ataaaccgga cggcccgcca 3304381 gcttcggaag cacctctttc agcggttcaa gcacttcaaa ttttgagatg tgcatgccgt 3304441 tttccttcgc ccattcaaac tcttctttca tgccggaacg gattccgaat gaatacacat 3304501 tgtgcggtcc gatcaattct gccgccttac ggatcggcgt ggagtgagaa agcggttctc 3304561 cctcataatc aacacgaaga tctgtatgtg cgtcaaaatg gataatcgca aggtctgggt 3304621 atttcttgta catcgcttta atgacaggcc atgacacgag gtgctccccg cccataccca 3304681 ttgggaactt ccctttttct aaaatgctgt ccacgtactc ttcaatcata tccaggcttc 3304741 gctgcggatt tccgaacggc agcggaatgt cgccagcgtc aaagaagttc aagtcagcca 3304801 gatcgcggtc taaatatggg ctgtattcct caaggccgat tgacacctca cggattctgc 3304861 ttggaccaaa gcgtgagccc gggcgatagc tgactgtcca gtccatcggc atgccgtaaa 3304921 gaatggcgtc cgcctcttcc cactcgggac ggctcgcgat aaatactttt cctgaataag 3304981 cttcatcaaa tctcatctat aataccctcg ctttcctgta aaaaagcgca agattcgctc 3305041 ctgcgccata ccttcattat ttaatcaggt cactcacaaa tttcggcaga acaaacgccg 3305101 ctttatgaat atcttttgtg taatatttcg tctcaatatc gaagaaacgg ctgtcttcca 3305161 ctgcaagcgg atcatatttt ttcgagccaa ttgtaaatgt ccacaaaccg cttggatatg 3305221 tcggaatgtt cgccgtatac agcttcgtaa tcgggaagat ttccttcacg tcgcgctgta 3305281 catttgtgat taattccggt gtaaaccatg ggttgtccgt ctgcgcaacg aaaataccgt 3305341 cttctttcag cgcttttgcg attcctgcgt agaatccttt tgtaaacagg tttacagccg 3305401 gtccgactgg ttcagtcgaa tctaccatga tgacgtcata ttgattttca gattttgcaa 3305461 tgtgcataaa tccgtcatct acctgcacgt caacgcgcgg atcatccagt ttgcctgcga 3305521 tagaaggaag gaacttttta gagtattcga taaccttgcc gtcaatatct acaagtgtcg 3305581 cttttttcac gcttgggtgc ttcaggattt ctctgataac gccgccgtca ccgccgccga 3305641 ctacgagaac gtgctccgga tttgggtgcg tgaataatgg gacatgcgcc accatttcgt 3305701 gataaacgaa ttcgtctttt tcagatgtca tcaccatgcc gtccaaaaaa agcatgttgc 3305761 cgaactcttc tgtttccacc atttctaaat gctgaaactc cgtttgttct gtatgtaacg 3305821 tcttgttaac cttcatcgta atgccaaagt ttttcgtctg cttctctgtg taccaaagtt 3305881 cgctcaattg tcatctccct ttcgaggctg tattcattta ttgtaagcgt cttatcagct 3305941 tttattctcg gttgaaatct cattttcacc taaggaaaaa gtatagagga tggcggggaa 3306001 aaagtaaaga tgcgtcctgt tctgcgatgt ttaaaaacga tctttttttc tcataatagt 3306061 agaaacataa aaaaaggggg aacccgttgt ggatgcaatg acaaataaac ggctgagact 3306121 gacgctgaaa accgttcgcg cctttatctt tttaggggct tttgcggcct tggcggcagc 3306181 tgctgtgttt atgactgtca ttttgatagc caaataccag ggcgctccct cggtgcaagt 3306241 gccgcaatcc acgattttgt acgcgagtga cggctcaaag ctcggggaaa cgaactacgg 3306301 cgaaaagcgc tattgggtcc ccttaaagga catgaatccg acgatcgtaa aagcgacagt 3306361 ggcgattgaa gaccagaatt tctacgatca tcacggcttt gattataaac gcatggccgg 3306421 cgcggcgctt gctgacctga aagcatttgc caaggttcag ggtgcaagca ccatcaccca 3306481 gcaatatgcg agaaacttat accttgaaca cgacaaaacg tggaaacgga aatggaatga 3306541 ggcgttctac acgatccgtc tggaacaaaa ctattctaag gacgagatat tagaaggcta 3306601 tttaaatacg atttactacg gccacggcgc ctacggcatt gaagcagctt cccgcctgta 3306661 tttcggcaag catgccaaaa acctgacgga tgcggaggcg gcgcttttgg caggaatccc 3306721 gaaaggccct tccggctatt caccgtatgt caatgagacg aaggccaagg aacgccagaa 3306781 aacgattgtg cggatgatgg aaaagcagca gatgatcagc caaaagaaag cggatgaatt 3306841 gatcaaggaa cctctttcct atcagccttt gaataaacaa gtttccaaga gaaaggctcc 3306901 ttatttctac gacaatgcga tgagagagct ggaaaaaaag ctcggcatga cacgggagca 3306961 aattgaaacg agcgggttaa acgtctatac aacggtagat aaacggatgc agcgcatcgc 3307021 cgaggagacc attaccgaaa cggttaacgc gggctctgac attcaagtcg ggttttcagc 3307081 cattgatccc cgcaccggaa acgttctcgc ccttgtcggc ggcagggatt atcaaaaaag 3307141 cccgtttgac cggacgacac aggcgaagcg ccagcctgct tcgacgatca agccgttgct 3307201 gtactataaa gcgattcaga gcggatttac gccagtcact ttgatgaaaa gcgaagaaac 3307261 cgagtttcaa attgatgcaa agggagaaac ctattctcca agcaactata acggatacta 3307321 tgccaacaag ccgattacgc ttctgcaggc gctggcgctt tccgacaata tttacgctgt 3307381 gaaaacgcat ctttttctcg gcacgaacaa acttgtaaag acggcaaagg aattcggcat 3307441 taccgcccat cttcaagcac tgccgtccct ggcactcggc accgaacccg tacgtccgat 3307501 tgagatggtc aacgcctatg ccatgctcgc aaatggcgga aagaaaatcg aaccgacttt 3307561 tatttcaaga gtaacggacg cagccggcca cgtgctgtac gaaaacccga atcagcataa 3307621 acaggtgctt gatgaaaaag ccgcttttgt cacagcgagt atgatgacag gcatgtttga 3307681 tatcgattta aatggatata cgtcggttac ggggcgaacg atagccaacc gcctgacaag 3307741 aacgtatgcc ggaaaatcag gaaccaccag cgcagacagc tggatgatcg gcttcaatcc 3307801 gaagctggcc gccggtgttt ggaccggcta tgacaaaaac agcaccatcg actcggtcga 3307861 agaaaaaagc tatgctaaaa ccatttgggc ggacttcatg gaggacgcgc tcaaaggcga 3307921 accggaaacc gcgttcaagc cgccaaaagg cgtaaccggt gtgtacattg atccggaaac 3307981 aggctactca tcaggtcccg gctgcgccgc taagcattac acatattttg tgaaagggac 3308041 agaacccgca aacgtgtgct acggggcaga acccgcaaaa caaacaaaag accggcttcc 3308101 atccaaagaa aagcccgctt ccgagaaaaa gtggtgggac aaatggctgg ggcgacatca 3308161 ttgaaaataa cccggctcct cggaggccgg gttattcgta tggttccttc ataatcgatg 3308221 gaagaatgtt agacaatcga gctgaacaat cagttttggg ataaagtggt gaatttctca 3308281 tttcttcggc gctggctttc atctcccagt cgccgactca tatcccccta aaaatgaaaa 3308341 accccgagtc ttgtttcggc tcgggatttt ccatgtccta tttctgtatc accagtttac 3308401 tcaatgttta cgaaaaatat ctcaaatact ttaaaagttc acaaaaaatt cataaattaa 3308461 ttgttttctg gaagcaggct cgtttttaac tcatctgagg aacggtccca taggccctga 3308521 tcatgctttt tcagaaattc gcctagtaca cgcttcgagc tgtcgtccat tttatcaacg 3308581 atgattttcc gtttcatgga tttatccatc agattcacat gctcaggcag tgacttgtag 3308641 cctcttctga tgcttctgtc gaccgtcatt tcacaggctg tcacaccagc gtaataaggc 3308701 ccctcttctt ttctgtcaat cgttacccac acaagccagt atggttttcc gttcggcact 3308761 tcttctttat tcgggagaaa tttaattcct ttttcaacgg tgctgcgggc atgcatagcg 3308821 ccgatgtcta cgaacgcttc tttttcctct acatcaacga atacgggaga aatgttatca 3308881 aggctgagtg cccctacgcc aaaaccgccg tgtccgtctg tcggatcact tttgataata 3308941 ttaaacccga ttgatttttt ctttttttct tccatgaagt tctacctcct acaaaagcgg 3309001 ttgaaatatc gctgaaaaca gctttaaaat cgaatctctt cctgcattga gcatcggcca 3309061 cagcacgtaa gatcctagcg gtgtcacaaa cagcaccaaa aatacgataa agccgtagct 3309121 ctccgcctgc gtcattttgg cacgcacgcc cggcggaacg agatcttcta taattcgata 3309181 gccatcgagc ggaggaagcg gcagcagatt aaataaaaac aagacaagat tcagctgtat 3309241 ccaaatagaa aaaaactgat ccagccccgt gctgaacgcc gcaagcattt ccattccgta 3309301 cgcatgcatc aacactaaca aaaagaaacc aataaacgca agaatcaggt tactgacggg 3309361 cccggctata gatacgagca caccagcaag ccggggtttc ttaaagaaac ggcgattcac 3309421 gggaatgggg cgcgcccacc cgaatccggc caccagaatc aaaatggttc cgaacggatc 3309481 aaggtgttta atgggattca gcgtcagtct tccttgtttt ttcgccgtat cgtcaccgaa 3309541 tttgtatgcg acataagcgt gggcaagctc gtgcatcgta aacgacacaa ttagcgtgat 3309601 gacgaggtat ggcattaaag ataacggata atataaaaaa cggtccaagt gagatatccc 3309661 tctttctcaa aatgcaagaa tttactttat tcagtatact ataagaagcc tctttttcta 3309721 aagagaggaa acgagataaa ggaggattca gcacccatgc catacgtaac tgtcaaaatg 3309781 ctcgaaggcc gtacagacga gcaaaaacgc aatcttgtcg agaaagtaac agaagccgta 3309841 aaggaaacaa ccggtgcttc tgaagaaaaa attgttgtct ttatagaaga aatgagaaaa 3309901 gaccattatg ccgtcgcagg caaacgcctg agcgatatgg aataatctct ataaagccgg 3309961 cgcttcgcgc accggctttt attatcccta ttgagccagc ttcgcaataa tcgccaagaa 3310021 cgtctttttc tcttcggctg ttaaacgttc aaacatgcca tcaatcagct gctggcggtt 3310081 ttcgatcatt tgttcagccg ctccccggcc cgattcagaa agagtaatcc atacagtgcg 3310141 gcggtcattg ttatttctgg atctctcaat aaacccttcc tgctctaaat gattcagagc 3310201 tgtggtcgtg gcagagggag acagtgtgac ctccttcaaa atatccttta tggtgcagct 3310261 cccatgtctg tatatgatcc gcagaataaa ccctcttaca ttattcacgt gtttcggaac 3310321 ggtggcttca tctaattgct tcgtgctttt caaatacttt gtaagtgcgt gatccagcaa 3310381 atttgcttcc agtttgtcat ggtccatgtc aatttcccca tttcgagatg cattcataac 3310441 atacgaacga tatgatttac ttattatttt actgattccg aatagggaaa gtcaaaaaag 3310501 caaaatgtga attcacagct tttatcctac atgcctcgat tttccacctg tttcacaagt 3310561 ttatctttaa aagtttggaa aggaacgtgt tcattctgct gatgtccgaa tcggcggacg 3310621 tttaccgcat tctcctgctc ctcatgatct ccaagcacca gcacgtacgg aattttttgc 3310681 acctgcgatt ctctgatttt atagccgagc ttctcattgc gctcatcaat gccggctctt 3310741 atccccgcct gcttcagctc cgcctgcact tttctgcaat agtctaagtg aacgtgcgaa 3310801 accggtatga tttgaacctg gatcggtgcg agccagactg gaaaagcccc accgtaatgc 3310861 tcgatcaaaa tgccgaagaa acggtcgatt gagccgaaaa ccgctctgtg gatgacaacg 3310921 ggacgaacct tctcattgag ttcgttgata tatgttaaat caaatttttc cggcatttga 3310981 aaatcaagct gaattgtcgc gcattggtgg ctccgtttca gggcatcttt tatatggaaa 3311041 tcaattttcg gcccgtaaaa cgccccatcg ccttcattga tctcataaga gaggccaagc 3311101 tcctcaagga cgcgtgctaa ggcacgttcc gacgcttccc aaaggctgtc atcgcctaat 3311161 gaatcctccg ggcgagtcga aagctcaaca gaatactcga aaccaaatgt ccgatatacc 3311221 tcatcaatca gccgaatcgc ttctttgatc tcactctcaa tctgatcctc ccgaacgaaa 3311281 atatgggcgt catcctgaca gaacgtccga acgcgaagca ttccgtttaa agcgccgctg 3311341 tattcatggc ggtgcacctg tccgaattcc gccatgcgaa tcggcagatc ccgataagaa 3311401 tacaggctgt ttttaaagat gagcatgtgg ccggggcaat tcatcggctt cattgcgaat 3311461 cttgtatcat ccacttctga aaagtacata ttgtcgcgat aatggtccca atggcctgac 3311521 tgctcccata accgctgatt catcataaac ggcgtacgca cctcatcgta gccggcattt 3311581 gtttgcagct cacgcgagaa gcgctccagc tcattgcgga caatctgccc tttcggcaaa 3311641 taaaacggca tccccggcgc ttcttcagaa aacataaaca gccctaactg tttgccgagc 3311701 ttgcgatggt ctcgttttgc cgcttcttct agcatatgca ggtgcgcatc caaatctttt 3311761 ttcttttgaa acgcaacccc gtacacccgc tgcaggactt catttttgct gtctccgcgc 3311821 caataagcgc ctgatactct tgtcagtttg aacgccttga tcatccctgt agaaggaaga 3311881 tgcggccctc ggcacaggtc aacgaattcc ccttgctggt acagtgtgat atcctccccg 3311941 cgcggaatat cctttaaaat ctcaagcttg agccgctcgt ctttttgtgc aaacagctct 3312001 tcagcttctt cgtaagaaac ctctatacgt ttgatttcaa ggttctcatt tattatgttt 3312061 ttcatttctt tttcgatggc ctctaagtct cctgatgcca agcttttccc cagcttcatg 3312121 tcatagtaga agccgtctaa aatcacaggc cctaccccca atgacacttc gccgtacagc 3312181 cgttttactg cttgggccag cacgtgcgct gttgtgtggc gaagcacctg caagccttct 3312241 tgtgaatcga gtgtgacaat cgaaagctca gcatcctcct ccagcttgaa actgagatca 3312301 acaagcttgc cgttgacctg acctgcggcc gccttctttt gcagactgga actgatcgaa 3312361 ccagccgctt ctttgattgt gatgcctttc ggatattcct ggatctgtcc gtccggaagc 3312421 tgaatgtgta catgtttgct cattttagaa cactccttat tcattgttgt atataaaaaa 3312481 acacacccgt cccgcagata gggacgagtg tgtgattaac ccgtggttcc acccaagttc 3312541 ccgacaaata ctatgttgtc ggctcggtgc tgtaacgcag catagacggc attggttact 3312601 tcagttcccc aatgctgctc caaggcggta aatgatattc ctaagctggg aagctctcac 3312661 ctttccttcc ctctctgaaa accgtaacta tcattcatgt ccttttcatc gcatgtattc 3312721 aattcataaa aaaacacacc cgtcccacag atagggacga gtgtgtgatt aacccgtggt 3312781 tccacccaag ttcccgacaa atactatgtt gtcggctcgg tgctgtaacg cagcatagac 3312841 ggcattggtt acttcagttc cccaatgctg ctccaaggcg gtaaatgata ttcctaagct 3312901 gggaagctct cacctttcct tccctctctg aaaaccgtaa ctatcattca tgtccttttc 3312961 ttcgcatgta ttcaattcaa ataaaaaaac acacccatcc ctctaaaagg gacgaatgtg 3313021 ttgatcatcc gtggttccac ccaaattccc gatcaattac acatgatgat cggcttaaag 3313081 atgctgtaac gcagcatgac ggtatcagat acttgttttc cctgatacgg ctcaaaggcg 3313141 gtaagctgct ttccctgcgt taggaagatc tcagctgtcc ttccctctct ggaaaccgta 3313201 aaaagcatct cgtgtcctta tcagtgcctg ttgtttcaat aattttttat atcttactat 3313261 atattcccac aaagcgcaat cagtgattta cattttttct gacgcggcag tcccgttatg 3313321 ggcagccaga aacagccata caagcaatgc agcgaggctg tatgccgctc ccatcatcaa 3313381 aaacgcaaac ccggcaccag cataccaagt ggcggacaga tgaatgatca ccccggttat 3313441 cgctacgccg accaaggctc cgatttgccg gtttgcattt aacgccgcac cggcgatatt 3313501 cgtatgtctt tgcccggcag cctgcatgat cacagttgtc atggcaggaa ctgtaatacc 3313561 ggtacagagg ttcataacag acatcaacac cgccagctgc caataaggaa aatccggaga 3313621 aatcagcaca aacaacagca atgcaatgat acagctgacc gccattgata caaacataag 3313681 ctgaccggct tcaaaccgat tcgccagacg ggcaaacagc agattgccga tcacgaagac 3313741 cgccatcatc ggcagcagct ccactccagc cataaaggaa cttgcccctc ctgcttcctg 3313801 caaaaaaagg ctgagcataa acatgccgcc aaaaagggcg aaattcagca aaaacccgat 3313861 aaattgggca gctgagaagc ggccgttttt gtataaggac gccggcagga tgggtgtttt 3313921 tgcagaaatt tcccgcagca aaaacagcac aaatgccaaa accgctgcag taaatgctac 3313981 aagaatcact ggcgagcgcc agcccgctga aggcccctgt atcaaagcat aggaaagaaa 3314041 cccgagagcc atcatgccaa gcagatgccc gatgatgttc acgcggctgc ttttcccagg 3314101 aacgcggctg aggattcggt aagctgaaat gagcgcagca gcccctattg gcacattgat 3314161 cagaaaaata ctctgccagc ccgccaactg taccagcacg cccccgataa aaggcccaag 3314221 ggctgaagcg gcggaaacaa gcgcggccca cagtccaaac attctcgccc gcgcccgctc 3314281 atcaaggtaa gaggcagcca aaaggctgag tgagcttggc ataaacaaag ctgccccaat 3314341 tccctgtatg agacgtccgg caatcagcat ctgcccattt atagatgcag cgcatagaca 3314401 ggaggccata acaaaaacgg ctagacccaa gatatagatc gtcttcgagc cgaaacggtc 3314461 agccaaggct ccgcccgcca gcagaagcga cgcaaaagta agaatgtacc cgtccacaac 3314521 ccacgttaca cctgaaagtg acattgaaag agtgtttttc atatcagcca tcgccacatt 3314581 cacaacggtc acatcaagag ttgccatgag gaaaccaagt gcgagcacga tcagcacgga 3314641 tatgcctgtt gatgatgttg attcttgtat agacccgcta tttttcatta caattgccct 3314701 ttcacttgct tgattaccca atcatctatt ttttcaagat catacaattc cccgactctg 3314761 tccataacat gctgcaagga ttcttctctc ataagattgg accatttatc ctcgatttcc 3314821 gccatgactg tctccagcac acagtgactt tcaccctcaa atacagattg cagcaagcct 3314881 ttcccctgat acatcgaacc tctgccttcg accgcttgat aaacatcata aagcgtaatg 3314941 tcagccaaag gcttcgtcag ggtaaaaccg cccttcgtcc ctggtaagga ttctgccaaa 3315001 ccggcttgaa ccaatgttct catcagcttc ttcaagtaag acggagacac gcgcaatcgc 3315061 tggcttatag cctctgacgt caaagaagcc tgtaccggca gccgtgacag taacagcagc 3315121 acagaaaccg cctgctccat tcctgatttc attttcatcc tattcactcc tgattcatta 3315181 tggataacta ttatccataa tgaatctctt agcagctttt gtcaataaaa aaagcaaaag 3315241 aaacggatca tttcttttgc ttggtatggt taacaaatct gcttcagttc ctctatgtat 3315301 tgaagcgctt cgtcatattc ttcatttgta tatttttgct tgcttttgat ggtaaagact 3315361 ttttctttct tttcctcatc ctcaagcccg tcaaagtaaa ggatcgtgga aaccagctct 3315421 aaaaaccgtg atgaacggct gtttacactg tcgatatagc ctttcatatc cggcatgtcc 3315481 agatcagcat ggtctaaaaa tgcggagcct gtctcagtca gcgaataccg gtattgaaag 3315541 tagccgccct ttttttcctt cacctcatgc agaaatccaa ggttgcacag ctcttcaatc 3315601 tggagcgtca gttcctctga atatggtccg taaaagtgaa aatcatattt ctcatagaaa 3315661 ggaaactgca ttttcttggc gatataaatc attttctgca gcttctttcg cccgatgatt 3315721 tctccagaat ccgagaacac cttcatcagt tttgcatgtt ctttcaacaa attcccgaca 3315781 tctccttttt ccttctttcc aatttctatg tcagtcccag cagctgccgg attttcattt 3315841 tcgcttccgg atgtttagtg ccgtcacaaa tcaagtcctt tggatagtac agcttgtggt 3315901 ccgtccgccg tttacctgag atggattcca caatagccga ctgtctggac agctctttaa 3315961 tttggccgtt ttgcgtcaag agatggatcg gcagacgctc ctcttcctct cctggtcggt 3316021 aaaaatcgta tggcagatct gatgaagaat caacgaccaa ataatagctc ggatcgatcc 3316081 ccgcctcttt gaacaatgaa gtcagctcaa aataagccga catttcttca ttcggattga 3316141 attcaacgta ttggaaaagc tggcggttaa tgaatctgcg gcacaagtcg gataaaatcg 3316201 cgtcttcttc atcctcccag gcctggaagt aatacaaaat aatagattca tccagcttta 3316261 cataatcctc cagtgtcaat tttccttcaa aaatagaata gaaatgaacc ggagcgtgag 3316321 tgaagacata gccttcatcg tgcagctgct tcgccctgtg aagaatcttc gttaaaatga 3316381 cctctgcact tctagtcaca ggatggaagt agacctgcca gtacatttgg taacggctca 3316441 tgatatagtc ttcgacagcg tgcattccgc tttctttaat gacgatctga tcctcgcgcg 3316501 gccgcatcac ccgaagaatc cgctccatat caaaatggcc gtagctgacg cccgtataat 3316561 atgcgtcgcg ctggaggtaa tccatgcggt ctgcgtcaat ctgactcgaa atcaggctga 3316621 ccacttgctt gtttttatat gttttggcaa tgacttcagc aacatcctga gggaaacccg 3316681 ggctcacctt tctgagcacc tgattaacct ccgtgtctcc caaaatgata cctcttgtaa 3316741 aatcctcgtg gtcaaggtga aagacctttt caaatgaatg cgagaacggc ccgtgcccga 3316801 ggtcatgaag cagcgccgcg gccaaacaga gttcgcgctc actgtcatcc cattcagggc 3316861 ggcctttaaa gacgtcatca accattcttc tgacaatttc atagacaccg agagaatggt 3316921 tgaaccggct gtgctcagcc ccatggaacg tcaaataggt cgttccgagc tgcttaattc 3316981 tgcggagacg ctgaaattca cgggttccga tcaaatccca tatcagcttg tcccgaacat 3317041 gaacatagcg gtgcaccgga tctttaaaca ctttttcttc tgataatttt ccatttggat 3317101 acgccatcgt cattccctct tttttttagc cgtgtttcta ttatatcgac tctattcttt 3317161 gaaaacatcc ttgaatttgc ccggcgattt gttccatctt catgaaaaac acatcttgtg 3317221 aagcaaaaaa gcctgacctg agggccgagg ctaagaaaaa atatgttttt acttttttat 3317281 tttctttttt actttgtcaa tcagctcatc ctctgtcgga gctgacagcg ggcgattgtt 3317341 cacaaaagca aatgattttt tccgtccggg cccgcaataa gattggcatc ctacctcaac 3317401 ctttgcgtcc gggtccactt ctttcaaacg cggcagcaat gttttgatat tagtggcttg 3317461 gcaatcatca cacactcgaa attcattagc catgacgtac gcttcccttc atttctatgt 3317521 tcatctatgt gaataaccta aaatcacgtt tcaaaaaaaa tcacatcaca cttcatttta 3317581 caaggattcg actgttcctg caagccgctc catccttcgt atctcctatt ctttcagcca 3317641 atttgtataa atattttcca acctggacat tctaatacca tgaaaagaaa aatgggagtt 3317701 gagataaatg acaaaacagc gacaagacgc ttggtcagag gaaaacgatc tgcttttagc 3317761 cgaaacagtg cttcggcatg tgagggaggg cagcactcag ctgaacgcct ttgaagaagt 3317821 cggcgataaa ttaaaccgga catccgcagc ctgcggattc agatggaacg cagtggtccg 3317881 ccatcaatat gaaaaagcgc ttcagcttgc gaagaaacaa cgaaaacagc ggatgagagc 3317941 gctcggaaac gggcagcccg cgaaaaaaag attattatat cagcctcctg ccgttgatcc 3318001 tgaaatcatt caagaaaccg ctgcagaaga gccggttaaa acggaaacac catctgtcga 3318061 aaatgagcaa cctttaatgt ctggcgaaca catgcctttt gttgatgaaa gctttaagga 3318121 agagttagct agtctatcac acttattgtc tcctcaaacg cctgcagctg cgcctgagat 3318181 gacgatgaat gatgtgatcc gcttcctgca gaattacgaa ggcaatcacg agcaatcatc 3318241 agcattaaaa atggaaaacg agcgtttaaa gaaagaaaat caggaattgc aaaacaaaac 3318301 agagcagcta gaggcagaag ttcaaaagct tgaaaaagac caaaaaacga tccaagaaga 3318361 ttatgaaacc ttggtgaaaa ttatgaacag agccagaaag ctagttttat ttgaagaaga 3318421 tgaacatgcc tctccgtcct tcaaaatgga ccggaacggc aatttagaaa aattagcgga 3318481 atgacataga aaaatcccaa aacgggcagc tgttttggga ttttcgccat gtgcaaaatc 3318541 cccttttcta ttgagaaaag agaatttcct cattttgcag ccggatcagc tattcttgta 3318601 aaatgaggcc aagcttatgt gaatctatta agacatgtga gctgcctcgg ccgttttttg 3318661 tttccgaggc gcagcagaaa tgaccaaaag ccccagcatc ataagcgcaa tgcccagcca 3318721 cgaggaaggc gaaagcattt cccctatgaa aaacacgcca agcaatgaag ccgtcagcgg 3318781 ttcagctaaa gacagcgtga ccgccgccga ggccggaacc ccggtaagcc ctttcgcaaa 3318841 caaaaagtat gcggcacatg ttgcaattaa cccgatgtaa aggcttgttc ccagtcctct 3318901 aggggtcaat atccacgaga tatctaactg ccataatagc ggcgtcagca agatggcgct 3318961 gatcatgaat acaacggcgg aggtcgctcg cggaggctgg gttttcatca tcgctttact 3319021 gatgagcgta tagcctgcaa aagaagcacc cgctccaagc gccataagaa caccagccac 3319081 atcaatccga acattggaac tgtcggaaaa cagaagccag caacccgcta aagccagcac 3319141 agtcgcaatc caccaggagt ttcgcgggcg tttcttcaat acagcccatt cgagggtccc 3319201 ggcaatgata ggcgcactgc cgatggcaat cacagttccc actgcaattc ccgtttcttt 3319261 aaccgctgtg aaaaacagcg gctggtaaca cgccatacaa acagcggcta aaaatacgag 3319321 cggccatgcc caatttttca cgtgaagctc ccggctgatc caaaccgcaa gcagcatggc 3319381 gcttcctcct attaataacc tgaacgctcc aaatgccagc ggtgtggcgc tttctggagc 3319441 caatgcctga acggttcccg tggtccccca gaaaaaagcc gcaatcaata caaaaaggct 3319501 gtaaatattc cccttcatct gcctctcccc tttaatatgg atgctgatgt cattttatcg 3319561 tttttctttt tgtcgtggtt atctgtatgt aagaaggact tatctgaaaa taagattatt 3319621 gaggtaaaat gccgcttgag ataaaaaatg catgccggca tatacagccg gcatgcgaag 3319681 aacgttcacc caaatacctt tgcattccgc tcagccatcc ggacgaggtt tttctcaaat 3319741 tccatttcct catcaatgga cagtccagct gaataaagat gggtgcttaa cgcttttaat 3319801 tccgtcaata aagcgaacat taagtcttgt acggagatgt ctttttgaag aagctcactt 3319861 aaggacgcca tcgtttccgg acgtatttcc ggatagacgc cttttttatc gttttgtttg 3319921 tctttcagcg ccgcttgata gaatcgtctg atcaagtcgg ccctttcact gccgctttta 3319981 tctgcacaga gataaatttg aacagcgact ccgccgcgaa cgcgtctctg agagatgccg 3320041 gcgaactttt tgccatttat actgaggtca tagctgccgg gacaataaga cccttcaatt 3320101 tcataggctt cgatctttgc gttgtacggt ctcagcattc gtctcatcag ctcgaccatc 3320161 gcttcatatc ctttgtctat atcgatgcct ttcttttcgt cctcgaatat gagagagata 3320221 tttaaaacac cgtcatccaa tacgacggca agaccgccgg aattgcgtac gatcacacgg 3320281 tatccttcgc tctccagcaa ggagatacca tcctgcaaaa acgggaggcg tgtatcctgt 3320341 attccaagga caattgtatc gtggtgcacc catgagcgcg ctgtcgccgg cgacacgcct 3320401 tttccgacgg acatgcatag cgtatcatcc attgcgaagg attgcttcgc atcaaataaa 3320461 gggccgagac tggattggtc aatgactctc catttcggct gcatcagtaa atcaatcggt 3320521 tggtttgcca tctatgtaaa accctttcat gttaggctta ttgaacgaaa actattatat 3320581 catttcagca gctgtgattg ataattgctt ttcagcatcg taataaaaat ttctttattt 3320641 tttgtattct ccatgagagg agaatgaatg taagacagct tgcgctttaa cgagaaatta 3320701 ttaatatgca gaattgaaat ttcgcggtgg atcaaatcct tacgcagcac gcttctggat 3320761 agaaccgaaa gtcccatgcc gttaatcacc gcttccttta caccttgatt gctgctgatg 3320821 gtaaacattg atttcggccg aagtccattt gaactgagta catgatcgag atattctctc 3320881 gtcccggagc ctttctctct tgtcacccac gcttcgttct gcaaatcgct gatcgaaatc 3320941 tctttccgcc cggcgagcgg atgctgattt ggagcggcaa tgcacatttc atcctccatg 3321001 aacggttcaa tttccagctc attctcgttt gtatgtcctt caatcagccc gatatcagcc 3321061 tgaagcatcc gcacacgctc gctgacctcc tctgtattgc caatcatgac atctagattc 3321121 agctctggat acagcttttg cagctgggcc aatagcggcg gaagaatata ctcaccgatt 3321181 gtaaagcttg cagctatttt caattcaccc ttcacatagt gatgatgcgc atagatttca 3321241 gccttggctt gttcgtagag aaacaccatt tgctttgctc tttgatataa aatgtctcct 3321301 gtcggcgttg tcgtaaagtg ttttggcgac ctgttcagaa gagccgtttg aaattctttc 3321361 tcaagatttt tgatatgcag actgacgctg ggctgggaga tcatcagctt ttccgccgct 3321421 tttgtgaagt ttttttcttc taccaccgct ataaacgttt tcagcacgtc gtaatacaaa 3321481 aaccccaccc ctgtcattaa tgaaatatat ggttatgatt agttttcttt attgtactca 3321541 tatcatccgt cttggtaaag aagggctata cagaagcgca aaaaaggcag ccctcggtcg 3321601 agagctgcca ttgtcttcaa ttttattaca gtgcttgcgc cgctgtaatt aatgcgagat 3321661 tgtaaacatc ttcagcgtta catcctcttg aaaggtcgtt tacaggcata tttaaacctt 3321721 gcaggattgg tcctaccgct tcaaagttgc ccaaacgctg agcgatttta tagccgatgt 3321781 ttcctgcttc aagacttggg aatacgaata cgttagcgtc ccctttgatc tcggaatccg 3321841 gcgctttttt ctcagctaca gatggaacaa atgcagcatc aaattggaat tcgccgtcaa 3321901 gtgtcagttc aggcgctttt tctttcgcga ttttcactgc atccgctact ttttctgttt 3321961 catcagattt tgctgagcct tttgtagaga agctgagcat tgccacgcga ggctcaatgt 3322021 cgaacatttt tgccgtattg gcactttcga tcgcaatctc ggcaagatct tggctgtcag 3322081 gtgcaatgtt gatcgcgcaa tctgcgaata cgtattgctc ttctccgcga gccatgatga 3322141 acacgcctga agtctttttc acgccttctt ttgttttgat gatttgaaga gccgggcgga 3322201 cagtgtcagc agttgagtga gcagctccgc ttacaagtcc gtctgcaagt cctttataca 3322261 ccagcattgt accgaagtag ttctcgtcta ataatgcttt acgagcctgt tcttcagtcg 3322321 ctttgccttt gcggcgttct acgaatgctt gtacaaggtc ttccatgcct tcatatgtat 3322381 gaggatcata aatcttaacg ccgcccagcg taaggttcaa ttcttttgct tttgcttgga 3322441 tctcattttc attgccgatc acaatcggat tcagcacttt gtttcctgca agcttgctga 3322501 ccgcttctaa aatacgctcg tctaagcctt caggaaatac aattttaacg tcttttccag 3322561 ctactttttc ttgcactgtt gaaaataaat ctgccacaat aaaacctcct caaaaagtta 3322621 caaaaacgct ttcttttact agcatactct tcttccaatc aaattcaaac agccaacttt 3322681 cattatagcg ctttcataaa aaaatcttat ttttctaact aatttaagtg actcaatctt 3322741 cccttatagg ttcttctatt ttgatggagt tatacggaag ggatgttcaa ggtttctcca 3322801 cagtagaatc ggataaacta tggtatagtg aaggcaatca tgaaaagata atgggagtga 3322861 agataaatga gtgaacagca aatgacgaat gaagcggcaa aaacgcttga cggctggtat 3322921 gcgcttcatg atttccgcac aatggattgg gcttcctgga agcttctgtc cagtgatgag 3322981 cgccaatcta tcatacatga attcaccggg ttgcttgaaa aatggggcgt agcccaaaaa 3323041 gaaggaaaag gatcgcaaac tctttacagc atcgtcggcc aaaaagctga ttttatgctg 3323101 atgatccttc gtcctacaat ggaagaatta aatcaaattg agcttgaatt caacaaatca 3323161 agacttgctg agttcaccat tccggcatac tcctacgtat cagtggtaga gctgagcaac 3323221 tacttggcaa gcggtgacgg cgatccttat gaaaatccgc atgtgcgcgc tcgcctttac 3323281 cctgaactgc cggaatctaa atatgtatgc ttctatccaa tggataaaag aagatctggc 3323341 aacgacaact ggtatatgct ttcaatggaa gaacgcagaa acttgatgag aagccacggt 3323401 ttaatcggcc gcagctatgc gggcaaagtc aaacagatca tcaccggctc tgtcggcttt 3323461 gacgattacg agtggggcgt tacattattt agcgatgatg tccttcaatt caagaagcta 3323521 gtgtacgaaa tgcgttttga cgaagtcagc gctcgctatg gcgaatttgg ttcattcttt 3323581 gtcggcaatc acctttcgct tgatacactt cctcaattct tatatgtata atatccccga 3323641 gctcgtttat tgagataagg actgatcggc cttctgctca agtttgccgt actttttata 3323701 tgcgaataca ctgagcacaa atccgaggac tgtgatggcg gcgcaaatca atccgacagc 3323761 tgcatagccg tatgccacat atacgggtcc cattaaagca gaacctaatg tcacggccag 3323821 attcgaggcg agactgtaaa acaccatgac ttttcctcga tgacgctctg agcagtcact 3323881 caaaatggtg ctgagcagcg tcaccgtcaa actttgcatt aatccccaaa taaataggct 3323941 ggcgattaac agaaacatag acgccggcgc atatggtaaa cacgccagca gaacgctgat 3324001 gacccccagc gcaatcaaaa gggagcgcat ttttccgatg cggtcggcta tctttcctgt 3324061 aatcacactc atggaaaacc cgattccata aatcatgata aataagcccg cagccgtgtt 3324121 tcctccggta aaaacgtcct gaagataggt gcctaaaaag gaatacatac cgtaaaaacc 3324181 aatcatatta caaaaggtta ttgtgatata aacaggtaca cgagggactt tcagcgcatc 3324241 ccggaatgtt cctgcgggct cttctatttc ttccttgccg ctgtttttat gttgggcatg 3324301 gcggcgcatt tcaaggagaa tcagcagaac aactaaaaca cccatcaggg cgaaaatcca 3324361 aaacgtccat ctccaatgca ggacgccgcc gataaatgat ccgagcggca ctccgaaaat 3324421 cagcgccagc gaccagcttg aaacgatcag tcccatcacc ttgccccggt atgtataagg 3324481 aacacgatca ccgacaactg cgtaagcggt cggaacaaac gctcccgcag ccaatcccga 3324541 aagcgcccgg cctaaaaaga agaaaaaaat attttgagct aaagcgcata tcaccgttcc 3324601 tatgataaaa atcataagcc cggccaataa gctcagttct ctggagtatt tatcgcctaa 3324661 tggaaccaaa agcggcgcac cgataaaaat cataacgccg taaatactga tagataacgc 3324721 aaggacgctg acatctgagc tgaaggcttt tgctaaatcc ggcagcagcg gtgagatcac 3324781 aagctcttca gatccggctg caaatacccc catcgttaaa gccagtgcca acaataacgg 3324841 aaaatgatgt tttgttttga tgtcattgtt ttgattgctg ttcattcttt ctcaaacacc 3324901 tcttccataa tcttcttatc ataaagttgt attatagttt agcattgttt tttctctatt 3324961 tacaattcga acgaaatatt tataagtttt attattttca tttaaatccc attatatatt 3325021 tctatatttc attctaaaaa tacatgagga tgtaacacgt aaaaaaagct ctccggcctc 3325081 ccggagagct ttttctattg cgcctctgtc tgcttttttt caatcgtttc atgatttata 3325141 cgctttttga tgcttagatg atagtatgca taacagaaaa taatgatcgg cacaccgcag 3325201 tataagccaa ttctttgatc cggaatgaaa ataaggctga tcaacacgca gccatataaa 3325261 caaaatccga gaatcgggac tagcggataa agcggcgttc tgaactccag atcattcaca 3325321 tttccgcctt ctgccaggaa acgcctgcga aagaaaaatt gcgacgcaca aatggacatc 3325381 cacgcgacaa ctgtcaccat gcccgagatt gagatacacc ataaatacac tgtttctgca 3325441 gccatgacac ttgtcagcag cgaacagcct gaaatgccta gcgtaatcag cagggcattc 3325501 atcggcacgc ctttttttgt cagtctggtg agaaaggagg gacccatttg atttgatgaa 3325561 agtgaccaca tcatacgcga cgccgcatac aatcccgaat tagcaacaga taaaatggcc 3325621 gttaagatga caaagttcat gatatctgcc gaaaatggga tgccgatttg atcgagtact 3325681 gctacaaacg ggctttcaat cacccccgcc gttttgtacg gaaggatggc aaccaagacg 3325741 aacatagcga gcacaaagaa aaacagcgtg cgccaaataa catttcgaat ggactttggc 3325801 agtgtttttt ccgggctttc actttcccct gccgcaatgc cgacaagctc cgttccctgg 3325861 aacgagaagt ttaccatgac cagcgtaaac ataacggcca gcaccccatt agggaaaagc 3325921 cctctatcag tcataaagtt agacaaaaag ggtgtctcct gtccgccttt aaagtcaatc 3325981 aagccaaaca cagcggctcc gccaatcaca ataaataata tgatcgccgc cactttgatg 3326041 cttgaaaacc aaaattccat ttccgcaaag cttctgacag agagcgcatt aatcaaaaag 3326101 atgacgatgc cgaacacgag gcaccatatc cagatcggaa cggagggcag ccacctttgc 3326161 atcaaaatgc ctgctgacgt cagctctaac cctactgtat tggcccagct gaaccaatac 3326221 agccagccaa tcataaagcc tgtcgactgt cccagaaatt tagtggcgta ggcctgaaac 3326281 gatccggcca ccggcatggc aacagccaat tctcctaaac aaagcatgac gagatacatt 3326341 aaaaatccgc cgatgatata cgcggcaatg gcgccgagcg gtcccgcctg gctaatggta 3326401 aagccagagc ctagaaacag cccagtgcca atcacccctc ccaaagcaat cataaacaaa 3326461 tgcctgcttt tcatgctgcg ctgcaattca tttttatgat tctgcatcat ccttccccct 3326521 ttggttcttt tgccgtgatg gtcatccggt agctttgcaa aagatgaacg gtggtttgct 3326581 gtatgaggag aggcaataca tgaaatgtgt acggtttata gactcgttct gtccatttat 3326641 ggccgtcttt tccgtacacg cccatattaa tggatggaat attcagcttg cgtatgtctt 3326701 tgaacggaat ggtcccaatc atattccacc cagggaagtt cctgataaaa gaatcaattt 3326761 cgccatcggt ttcgtgcagt gataaaaaac tgccgtctgc caagtagggg aaaaactttt 3326821 tgaagacaaa tgtttcgcct gtcgattcag cggttttgtc agccgcttct ttaatcacat 3326881 gctgcaaaag ctgatctctt gcgctatctt ctttcaaata gttatgcggc aggtaaggag 3326941 gtgcgtaaaa tagaatgact tttgcgcctt gatcggggtc aagcttttga agctcttcga 3327001 ttgcctgaaa gcatctcatg cgaagttcaa ggtgctcgtt ggctttgaat gtctgctcga 3327061 tacactgctc gggatctatt ccccggtttc tcagcttttc taagtattgc tccaggctat 3327121 acacttgaat gccccatgat aaatgtttct ttggcaggtt ggctcttttt acatattctt 3327181 cgtaataatc tgataatttt tgttctgtct cccggcatgc ttcctcagtg acttcaataa 3327241 gcaaatccat catttctttt gctgttcttt cataaataaa acaattgaaa tacaagctgg 3327301 tgctgacagc cgtttgcaca ttataggatt ccttgttatc acgctgatac aaacaggatg 3327361 ggggcagaac caactcccct tcaacctttt ctgccagatg gatgttattg tggagacggc 3327421 ttgtgatttc agatgaaatg aaatttgggt caatccctgc cagtgtatcg ccaacatgga 3327481 cttcacgccc gtaaatgtaa aagcaaggca acagttttcc cgcggctccg gtatagatat 3327541 atcttgtctg atcaccatcg taaagcgggg taataaaatc cgtattaata gcagccaaat 3327601 agtgaagctg tttttctttt tttagccggt tcagctctga aatgctggcg agaatgcccg 3327661 aatgctggct ctcctcatcg ggattggcca taaacaatac atttcccggc aacgtctcaa 3327721 ggttctccga aaaatgcagg agattggcta aatgcacggc gatgccgctt tgcatatcga 3327781 cagatcctct tccgaacatc cactcgcctg atttggcatc ccgctgaaca tcctgatcga 3327841 actcatagcg gctgaaatac tcggccaatt tctcacaatc aaaagcgata tcctttaaag 3327901 ggccgaaatc ttcaattcca actgtatcca gatgggcatg gtaaatgact gtatttcggc 3327961 tttctccatg tcctttaata aacgcaaaaa tatttttgcg tttgtatggg tcattgggaa 3328021 tggcctgttc ccacacatga ctggggtttt cctgaaaata aggatagctc gtgatcactt 3328081 ctttgatgaa atctgctttt gtcccttctc caacggtgcc gttcacgctg ctgaggctga 3328141 ccagagatgc tgtcagcgcc tccactcttt cagccggatt catgtgactg atttttgtat 3328201 actgcataaa ttgtcctcct gatcaaaaag ttgaaatcgt gcgatccgct aaagaatcgc 3328261 acgattttat ttctctcaaa tcaaaaagct tcggacgttg ttttggcttg catatgaaga 3328321 attaagtaat cgggaccgcc tgcttttgag tctgttcctg acatattaaa accgccgaac 3328381 ggctgatagc cgacaattgc tccggtacat cctctgttaa aatataggtt tccgacatgg 3328441 aaatcctcgc gcgcccgttc aatgtgcgca cggtttttcg tcagaagcgc acctgttaat 3328501 ccgtattccg tgttattggc aatctccagc atatgatcga aatcacgcgc tttgcaaatc 3328561 gcaacaaccg ggccgaaaat ttcttcctgc atcaagcggg cgttttcatc aacatctgca 3328621 aagatcgtcg gctgaataaa gtagcctttt gaatcatcgc cttctccgcc ggccaatagc 3328681 ttgccttcag atttgccgat ttcaatgtat ttcatcactt tgttgtagga tgcttcatga 3328741 atcacgggac ccatatacgt atcaggatct tctggattgc cgacagtcag cgttttggtc 3328801 agcgccacag ctttttccac cacttcatca tacacatcct gatgaatgac cgcgcgggag 3328861 cccgcagaac acttctgtcc tgaatatcca aatgctgaat acacgataga ggatgcagca 3328921 aggtcaagat cagcgtcctt gtcgacaagc actgtgtctt ttccgcccat ttctgcaatt 3328981 acccgtttga gccatttttg gcccggctgc actttggcag ctcgctcata aatccggcag 3329041 ccgactgcac gggaacctgt aaatgagaca aaccgtgtct tcggatgctc aactaagaaa 3329101 tcaccgatct ccgcaccatc tcccggaatg taattcagaa cgccgtttgg cagacccgct 3329161 tcctccatga cctcgacaaa ttttgctgcc actaccgggg ctgcgtcagc cggttttaag 3329221 agaatcgtat ttcctgtcac aatcgctgcc accgctgttc ccgccataat cgcgagcggg 3329281 aagttaaatg gagaaatgac gatgccgacg ccaagcgctt cgtaatgata ttgattgacc 3329341 tcgccagcac ggctcttcac cggagcccct tccttgagct ttaacatttg gcgcgcgtag 3329401 aactctaaaa agtctatcgc ttcagccgtg tccgcatctg cttccttcca cggttttcct 3329461 gcttccttca caagatagct tgaaaattca tgctttcttc tgcgcaaaat agccgctgcc 3329521 ttaaagagaa tatttgcgcg gtgctccggt ctttgttttt tccaggaatc aaatgcctgc 3329581 aatgcggctt gcatcgcttt ttcagcaagc tcttgatccg ctgtagacgc gtacccaatg 3329641 atctcttctt tatttgccgg gttaatagaa atgattttgc ggtccgtttc aattttttct 3329701 ccatttatga caagcggata atgcttgccg agctgagtgt ttacaaaggc caatgactcc 3329761 ccaaatgcag ttttattctt tgcttccgta aaatcggtaa atggttcgtg cgcgtatgtg 3329821 actgtcatat gtagtccccc tcgtgttatg aaatatatct tcgcatatga ataaaaatgc 3329881 aagaatcatg ccattttctt gtcttttgct gaaaaaactt gttgaatcga acagaaattt 3329941 gtctaacagg tgatcacctt tctctttttc cgatcttgaa cgcaaattta ttttgcgttt 3330001 tttgctcttt acgcaaaaaa caaatgcaaa attattttgc ggaggcttct caaattagac 3330061 ccatccgcgg aaacgcgatg cttctgccga ttttctgatg cccgtcatgt aagccgccaa 3330121 acgcatatcc actttatgtg ttgccgctgt ttgataaatt gtttcgaacg agctgaccat 3330181 gacgcttctc agtttttctg caacctcttc ttccgaccaa taatatcctt ggttgttttg 3330241 cacccattca aaataagaaa ccgtgacgcc gccggcactc gctaggatat ccggcacaag 3330301 cagcacgcct ctttcattca ggatcttagt ggcatcaatg gttgtcgggc cgttcgccgc 3330361 ttcaacgacg attgacgcct gaatgttatg tgcgtttttg gctgtgattt gattggagat 3330421 cgcggcaggc actaaaatat cgcaatcctt ttcaagcagc tcctcatttg tgatgacgtc 3330481 agtaaataaa ttggtgacca taccaaagct gtcccgttta tcgagcaaat aagggatatc 3330541 aaggccgtct gggttgtaga gcccgccatt ggcatcagaa atcccgatca ccttcgcgcc 3330601 cgcatcgtgc atgaatttgg ccaggaagct acccgcgttt ccaaagccct gtatgatgat 3330661 gcgcgcgttt tgcagcttga tccctttttt cttcaccgcc tcttcaatac aaatcgtgac 3330721 gccctgtgcc gtcgctgttt cccgtccttg cgatcctccc aaaacaagcg gtttacctgt 3330781 aataaagccc ggagaatcga attcccgcag ccggctgtac tcatccatca tccacgccat 3330841 aatctgcgaa ttggtgtaca catcgggagc tggaatatcc tttgtcggac cgacgatctg 3330901 gctgatggca cggacatacc ccctgctcag cctttccagt tctccaaatg acattgtccg 3330961 cggatcacaa ataataccgc ccttcccgcc gccgtaagga agattggcaa tcccgcattt 3331021 gagcgtcatc caaatggata atgcctttac ttcctcttca ttaacttctg gatggaagcg 3331081 aacgcccccc tttgtcggac cgacagcatc attgtgctgt gaccggtagc ctgtgaacac 3331141 tttgacgctc ccattgtcca ttttgaccgg aatgcggaca gtgagcattc tctgcggctc 3331201 tttcatgagt tcatacatat ctcccggata acccagcttc cgaagggctt ccttaatgat 3331261 tgtttgggta gacagaaata agttaagagc ttctttttct tcatctttcg agacttgctt 3331321 tgctgacatc tttttcacct cattgttttt ttggccggct gtaatgtaag cgctttaaaa 3331381 aatcagcccg ccaattcctt tcttcattgg attcaccctt atcatcatgc aagatccgta 3331441 ccagcttttg aatccacaaa aaaagagact gaaaacatct cagtctctga ctacaaatct 3331501 atcgattaac ggggatcaat caccagctgc gtttcagcat aaaaactgcc gattcccaaa 3331561 ccgtttacta catcgccttt aatcgtgtaa gtgcctgcgc gaggaagagt tttacgcacc 3331621 atgacaaggt caaattcgga tgcgcctaac aaatcaagcg taagcgggag tctgactgtt 3331681 tttccatcgt ttaaaatctg tgtttctttc agtgttcttc cattcactga atctcttgtc 3331741 gtagcatgaa acccgtcagg aaattgaaat tctaccgctc caagagaaag caccgcattt 3331801 ggtttatatg tcacttcaat atcagaaatg gtccactctt tcgtgctgtt aactgttttt 3331861 gcctcgattg atgcagactg tgcatgagct tggcccgaag gaagtaagat tgatagtaaa 3331921 acagctgaac tgatgaataa tgaagatacg aatgaagttc tttttagcat gacatttccc 3331981 cctaattgat tgttgaaatt tggccagagc gtcctctgca gaaaaagcgc tttttcataa 3332041 ttcgcgaatt accagttctt tttcttaaaa attaatctat catcattttc catggaagta 3332101 aatgtttttt aaggaatatt aacacttgga attcaatgag aattccttcc tgtttataca 3332161 aggttcaaat ggacgatttc cctctctttt tctagtaaca tctgcctgac attttatatc 3332221 ttttatccta ttttaaaaaa gggcaaaaaa agtcgaagat gcctctgctc ttcgattgat 3332281 cacgttccta tttttatctg aattcagtgt tccagttaaa accgatcgtc tcatcatccc 3332341 acggaattct tttttcatca ggctgatccg ggttatacga catggtggta aaatagataa 3332401 ttgtcagcgg cgtctctccc agcactctat atccgtgagc cacccctttt gggattaata 3332461 acagcatcgg gttgtcttcg cccatataat agacgtccgt ttctcctttt gtctttgaat 3332521 cctctcgaag atcgtatagg acaacctgag cgtggccggt tgggaagaac cagagatcat 3332581 cctgcttctc atgataatga aatgccttaa tcacacccgg atagcttttc gaccaagagg 3332641 cctgcccaaa atgctcaagg agattctcat cgtcccggac cagctcagca aaaaagcctc 3332701 tgtcatcgct atgcttcatc aattttttca ccttgactcc atcaatcaca cgcactgctc 3332761 ctttcctgca aatactctcg taacgcttcc cgccagtggc gggggcggat gccggcttct 3332821 tcaatagccc gatggctcag cacagagtat gccggacggg gcgttttgtt cccgtattcc 3332881 tctgtcgtta cagacaaaat ggctgtttcc agcccgcttt cttccataat tgccgtcgca 3332941 aactcatacc agctgcatat gcctgaattg ctgacatgat agatgcccgg cggatggctg 3333001 aacagcttga tgaccgcttc tgctaaatcc ttcgtataag tcggcgaacc aatttgatcg 3333061 ctgacaaccc gaagctcttg tttcgtttca gcaagtttca gcatggtttc aacgaaatta 3333121 ctgccgccat gtccgtacac ccacgatgtc ctgatgatcg tgctgtcttt tgtcgttaat 3333181 cgtatcagtt cttctccgag ccttttgctt ttgccataaa tggttttcgg atcgagggga 3333241 tcgtcttccc tatatggctg ggttcctttc ccattgaata catagtccgt gctgatatga 3333301 acatattgag ctccgatgcg ggttgactca agcgctgtat aataagcgcc gattccgtta 3333361 atcaagtacg ctttatcaag ctctttctcg cattgatcaa ccgacgtaaa cgcggcgcta 3333421 ttgaccacga tatccggctg ataatggcca aacgaatgcc gtactgagcg ctggtcagca 3333481 atgttcatca tcttctttgt taacgcaatg acctcatatc cggcttgctt cagctggcgg 3333541 catagttcca agccaagctg tcctcccgcc ccagtcacca atacctttgt caatcagatc 3333601 accttctcat cggtcattgt ctgtatacca ctgaatcgta cgcgcaatgc cttcttcaaa 3333661 cgtcacttcc tgccgccagc ccagttcgtt tttcagcttt gatgcattga tcgcatagcg 3333721 ccggtcatgc ccttttcggt cttccacgtg ggcgaacaat tcctcacagc ccagatgctt 3333781 caaaatgaca ctcgccagct ctttattcgt gcgttcattt ccgccgccga tgttatacac 3333841 ctcgccgtcg gtcccttttt ctaaaatcag cttgatcgcg cggcaatgat cctccgcaaa 3333901 cagccagtct cggatctgga gtccatcgcc atacagcgga acaggcaggc cctgcttcgc 3333961 atgacggata atcgtcggaa tcattttttc gctgtgctga taaggtccgt aattgttgct 3334021 gcatcgtgta atgatggccg gaagcttgtg ggttttcaca taagacaaca cgagcaaatc 3334081 agagcttgct ttgctggctg agtatgggtt attaggagaa agcggcgtcg tttctgtaaa 3334141 cgcgggatca tccgctttta aatccccgta tacctcatct gttgaaatat gaatcagctt 3334201 cttggctttt cctttcaaga ccgcttccgc caatcggtat gtccccatga catttgtggt 3334261 gataaacggc tccgcttggg aaatgcttct gtccacatgc gattctgctg cgaagtgaat 3334321 gacgccatcg taggtctcgt caaaagcgcg gtcgatatcc tcctgaacgc tgatgtcccc 3334381 ttttacaaag cgaaaacggc tgttttgctt taatttttcc atttcctccg ggtggctggc 3334441 gtacgtcagt ttatctaaaa cggtaatgcg cgcatccgtt tccctcagca tgagctttgt 3334501 aaacgtgagc ccgatgaagc cggccccgcc tgtaattaaa tatgattttg ccatcacttt 3334561 tcgtcctgtc ctttccgtaa agcctggtgt acaagctggg aagcgagata aagcgattcg 3334621 tgagttccgg catctaccca ccagcctgat aacacatcat acgtaagctg gctgttttcg 3334681 atgtatagat tattcacatc ggtgatttcc agctcgccgc gctttgatgg tgatatttgt 3334741 tcaatatatg aaaacacctc tgcatcatac atataaatgc cggtaacaca aaggttggtc 3334801 ggtggctgtt cgggcttttc gatgatggaa cgaatccgct tgtttttctc atcaatctca 3334861 gcaatcccga aacgttccgg gtcatcaact tctttcagaa gcacttttgc tcctttcccc 3334921 tgctgttcaa agcgttctgt ataaggcttt aatgaatctt caaatatatt atcacctaat 3334981 aataaaatga aagactcttt tttcgtaaag cgctttgcat aagacagccc atccgaaatg 3335041 cccgatgctg ccggctgtac ttgataagtg atagtaacgc caagctcttc cccgttccca 3335101 agcagtttgt aaaattgcgg catatgctcc ttttggctga tgagtaaaat gtcttttatt 3335161 ccggcttcct gcagcttcat aatcgaccag tatatcatcg gatacgggcc tacaggaagc 3335221 aaatgcttgt tgacggcttt cgttaagggc ataaggcgtg agccgtttcc tccggctaaa 3335281 ataacacctt tcacattaac acttccttac atgcattttt atatctcttg ttcatataaa 3335341 tcttgaagaa tagctgttac ccgtataatg cctttgccat ccacgagcgg ccttcctccc 3335401 ttgtgcaaag aaaggcgaag aggatagctg ctcataatgc gtgacatctg atagatgagt 3335461 gtttcatccg gtacaagctc acccaatcca agatcaagag cggcgccttg gtcagcaaat 3335521 gttttggctg tagccgtttg atgctcaacc tgagaaagaa caaggcacgg cacgccgatg 3335581 caaatggctt catatagaga gatgccgcca gcgacaatgg ctgcgtccgc ttgtttcatc 3335641 aaacctgcca tatcatttgt ctgttcgatc atcttgtact gcggcttctt ttcgatccgc 3335701 cttcggactg cctcttgatg cggtgaagcg ctccccatca caaacatcat gtttttgtct 3335761 tttatgtcgg ggacttgatc agcggcagcc agcactttaa aaataagctg cttcggatca 3335821 cttcctccta atgcaacaag gatattgcgg cagtctttct taagtgtgta atcctctctt 3335881 gcggcctgaa aggcggggtg aagaataaga tagtccggac cttcatagat gcgtgtgttt 3335941 ccctgaacgt acaccctgct tctgatgtca ccgtaaattc cgttaatgac tgcgtcacta 3336001 tattgaatcg atttaccgtt tttctcttca aaaagaacaa ttttcgcatc tgtctccgtc 3336061 tttattttct ttaacagctc tgcaggcgcg cctagaatat caaacaaaag caaatcaagc 3336121 ttcttgcttt ttatttcccg gagaataaat tcgtgctgct gcagctccgg ctttacgatg 3336181 acctgccaat gctcttcatg aagaaacgct tcagaatcct gattcgtata aaacgtaatc 3336241 aagcatcgct gtttgagccc ctccgcaagc ctcttcatcc ggacaacatg gcccattccc 3336301 ttttcatagc cgccgtctgc gaagatccca acatgcatgg ctagtcagcc tctcgttcgg 3336361 ttgccgcatc ggggttccgg ttcagaaggg tgataagctc tgaggcggat acatcggggc 3336421 gctcgcctgc tttttgatag agggccttta tcgattcata gtcttccttt gtatcaatgg 3336481 tcagccgata ttgaggggcg cgaaatcgtt ccggcgcctc taaaaactga acacgataaa 3336541 gagctggatg attccttata tataacgtga catgctcctg atattgatcc tccaaagcct 3336601 gaatacggct gatgtcaatt aacaggttgg cgttgaccac ttcgccgcaa atccctaatg 3336661 gggcattcag gatatacgta taatccgagc cttgatcaaa atgcgcctga atcattacat 3336721 cgagcagctc aggatcgaca aacggattat cacctgttaa ccggatgatg actgacggtt 3336781 taacagcttc tatgaccttc acaaacctat cgaggacacg ttcttcgctc ccgcggaaaa 3336841 cacgaaagcc ttgtttgata cagtgcgcct ctaatatgtc gtcagtttct ttgtcagacg 3336901 tggcgatgac aagattatcc cgatcctttt ggtaaaacgc gctttgccgg acacggtgaa 3336961 cgagaatatc aagtaaacga ttcgatccga gcggccgaag cacttttccc ggaagccttg 3337021 ttgaacccat tcttgcttga atgataaaga gaatatcatt catgaaacgg gctgtccttc 3337081 agtaaaatgt catcccagac aatgcctgtg tcggctggaa tgtctcttac agcccgaaca 3337141 ccgctggtca gcagttcaaa aaatctcggg tgcagcccct gcggcttttg tccgggccga 3337201 agcactgcga tattgtcttc actaaaggct tcaccttttt gaatcggagc tgttgtaaaa 3337261 atgcctctgt atgcaaagtt tctgatttct ccttcgatgg cggtcgttgt tttgtatgaa 3337321 ctgccaagca gtttttcaga gaccggcttt gtgatcccct gtttcagctc agcttccgtt 3337381 ttcctgatgc catcgaccat ttctttcaat tcatccggat ttaatgcaaa cgagtggtca 3337441 gcacccggca gatttttatc gatcgtaaaa tgcttttcta tcagttttgc tccgagccga 3337501 accgcggcac acggcgcttc tgtcggatgc tcgctatgat cggagaagcc gattaccgcc 3337561 tcaggaaaag cggcggcaag catcggaatg acgctgaggt tgctgtactc cggcggtgct 3337621 gggtatttcg ccacacaatg cattatggca atttgattgt ttccctctgc cctgatggtg 3337681 cgccaagctt cgtgaacatc agagatttca gctccggctg tcgagaaaat catcggcctg 3337741 ttcagccggg cgacatattt aagcagcggg agatggttaa tttcatagga tgcgatttta 3337801 aaagcgctcg gcgaggtaga ctgaagcaga tcagctgacc cctcgtcaca taccgtactt 3337861 aaaaagatca cctgcttttc gcggcagtaa tccaatagcg gtaaaatcca ctcagcaggc 3337921 atttccatag attgaaccaa agaaaaaata gagacgtcct tgcccgctgc cgtcttgtac 3337981 aaaccaggat ctttctggta catcctatca gcttggaaca tttgaaattt cacggcatcc 3338041 gctcccgctt ccgccgcggc gtctatcagc gcaaaagcct gatcaagctt cccgtcatga 3338101 ttaatccccg cctcagcaat aataaaaaca ggagcgtctt tgcctacagt tttattcgcg 3338161 atctgaaacg ctgccattat ttcgcctcct tgcccggcca aatatgataa tagtaatacg 3338221 attgttcagc ggtgaagccc attcgttcat aaaggcggat cgcccttaca ttgtgaagct 3338281 gcgtccccgc tgttaccgtt ctatgcttct gggtctccgg ttgttctatg agattcgcca 3338341 ataaatgaaa cgcaatacgt ttcccttcaa atcccggctt tacagccatc aaatcgagaa 3338401 tgcactcatc atctcttgat aagccctgaa gatagccgat gacctcgcca ttgtgtttag 3338461 cgacaatatt gaccgccgcc cttccattca gattgtttcg tgtccactcc tgaaatattt 3338521 cgtttgctgc atcgcggctg agatgaggat cctgaaaata tctgcttttt gtaaacgagt 3338581 ctcgggccag ctcacatatc gcttctgtgt ctccgggctc aggcgggccc agttcaaaaa 3338641 atggcggtgt tttgtcataa aaagacggag gcatcgccag cttcagcaaa ctcccgacaa 3338701 agtaagagga tggctgctgt tgtatcacat gcgcggctcc gatatcttca gccggaacac 3338761 ggacaaagat aaaatccgtt tcatccattt ggcgtacagt ataaaaagct tcaaacagcc 3338821 tctttagctg cccggtacta tttgccgcaa gaagtttgac gttcatgact ttcttctgaa 3338881 gcaccttgct ttcccacaaa gaatcttcgt aaagcaatac gccttggagc ctgctgtttt 3338941 caaaaaggcc gagggaaaat tgatacggaa catccaatgt aagctttctg ctttggagaa 3339001 attcctcaat tgcctctttg gagacatttt cttttaccgt atacacttaa tcagcccctt 3339061 ttacgatatc ccgcacagct tcaatgacat catctacatc atcgtcagac attgatggat 3339121 agagcgggag agaaagggtt cgtttatagt aattcatggc attcggaaag tccgcttcct 3339181 tatatccaaa ttgcttttga taatacggat gaatgtgtac tggaataaaa tgaacgctag 3339241 tgccgatatt gtattcatcc tttaaagccg taatcatttc gctgcgcgta accccggcct 3339301 ttttttcatc aacttgcaga acatatagat gccaggcgtg cctgccgtca tcatggacaa 3339361 acggcgtgat cagcccagga atctgctgaa aagcggtttg atagcggccg gcaatctctt 3339421 ctctccgttt ctgcatatca tccagccgtt tcagctgatg aagtccgagg gccgcctgca 3339481 aatcaaacat attcatctta tagccgggcg attcgacttc atagtaccag ctgccatttg 3339541 aagaataacg gttccatgcg gctttactca tgccgtgaag gcttagcacc cgtatcttat 3339601 cggcaagctc ctcatcatca gtcgtcagca tgccgccttc ccctgtcgcg aggtttttgg 3339661 tggcgtaaaa gctgaatgcc gttgcatccc cgatagaacc gatcattctt tgcttataag 3339721 tcgtatatac cgcatgtgcc gcatcctcca gcacgaataa accatgattt tgggcaacag 3339781 ccaatattgc atccatatcg caggactgcc cgccaaagtg gacgggcaca actgctttcg 3339841 ttcgcggtgt gacggccgcc tcaagcttta ccgggtcaat attgagcgtg ttttcgtcaa 3339901 tatccgcaaa cacaggcgtc gctcccgtat gaataatcgt attggcggtc gagctgaacg 3339961 taagcggaga ggtaatgacc tcgtccccgg gcccaatccc ttttgctttc aaagccaaaa 3340021 ataaagctgc ggtacatgaa ttcaccgcca cggcgtgctt cgccccgaca aacgcggcaa 3340081 actctttttc aaactgctga accttcgggc ctttagagag ccatcccgat tcaagcgttt 3340141 ctgtaacctc ctgaatttct tccttaccga ttaacggcaa tgagtaaggg agaaaatgat 3340201 ttctcttttg caccatttct ttgcgctcct atcattttat tcagtatctt cccgcctgta 3340261 atcaacccct gttttggctt tcagttccgc aaataaagca tttgttgatt ctgccaccgg 3340321 ataattagcc gctatgaatg ccaggcgcgc ctcttctgct ttttgatgca cgtcgggact 3340381 tcgaagaacc tcaaccaagg tgtgcgccag ttcatccggc tggtcaaaca taaaatcgcc 3340441 aagagactca taatacggat acgagcgatt tccggacgat tttcctatca gcacaggctt 3340501 ttgaaacagc atggcttcaa gaccgactgt cgaggtttgc gtcactgcgg catcaacata 3340561 cggcagcaaa tcataaagct ccagctcctt tttgatgact ctgcatgctt gatgtttttt 3340621 cgccgcctcg tgatacagat caagcttgtt ttttccgatt tcccacgggt ggggtttgat 3340681 aatgatttgc agctgcttct gatcagaaag cccctgcagc acaccggaat aaaagtcttc 3340741 tgaaaagggc tgagtggcaa tgagcacaat ttttttagtc ggctgaaaag caagttttcg 3340801 atagaatatg gacatatcca taggcgttct gttaaaaatc tgatcgaagc ggggatgtcc 3340861 cgttacgaga atctgctcgg gtttacagcc ttttcgtatg aaccactctg cttcatacgc 3340921 accaaaaaca gcttgatagg ttgtaaaaac aggaatgaag gcttcatctc ccatcaatgc 3340981 gccatgctga agacaaatgc tgacggcccc ttttctttga cacatgagag cgagcaccct 3341041 gctgtaaatg tcttctgccg ttccgacaat aacagctgaa atcttttcct gttcaaacag 3341101 cgcatcaact gtatcaatgg cctctataaa taaaggaata tctttgaaaa gccggtcgcg 3341161 aaacgcttga tcaccaaatg ccgggtgatc atcataaggg gcgagaagcg aacaggctgt 3341221 ttcgagatac tgcttcgaat cgcctttttg gcatgaatcc gcaatctccc gcttgctaat 3341281 tacaggcaga tcacaataat gcggcaaact ccatctggcc aaaacagccg ttttttcagg 3341341 atcaaattga tagtaatttt cgtttgaaaa acgcaggtaa tcaaagtgca aaatgacttt 3341401 ccctttaaca ggttcgtcat ttgttttaac gatgttttgg attctttctt caaaaaacgg 3341461 ctgaatctgt ccctcatcga tatgctgatc caccgatccg aataattccg gttcttcttc 3341521 catcatcacc ctcagttcag ggctgatgta ttgataaaaa ttactgataa gcccaagcgg 3341581 aatccctttg tagcgaagtt tgtcaaaaag ctccacgtac ttccggtaca gcacccaata 3341641 attgcttaaa taggccgaca agctctcacc ccattccaag cttttttaat gattcacgca 3341701 gctctcggca atttcgctgc ggaggaaggt tcctgacaaa ttcatttttt tctaattcaa 3341761 acagctgaaa gtgaatcgat tggtcggtaa tataattcag gtccagctcc tcatccagtg 3341821 ggtaaaacgg ataaaaatga ttgactctcc aaaagaaccg ggcatctcct atacggtaaa 3341881 acgccgggct ttcatcccaa taggagccaa acttctcctt taccttctca agcaccgaat 3341941 acctgtgcat caccgagcaa tgatcaattg cgcacggcgc gttccatgtc acttgagcgg 3342001 caggcctgac agtttctttt acaatgtcac gattctcgtt taaatgatag gttttggagg 3342061 ctgagtaaat cacagccttt tcaggatggg tatcgagctc ccgcaccatt ttcaggaggc 3342121 ggtccggcat atagatgttg tcatccgtcg cataggtgat atattcaccc tccgccatct 3342181 caatcgcctg attgatcagt gccgcgtatc tcgttttttc tgttctttcc ttcactccag 3342241 atatatcgct ttgataaaaa cgcactcggt tatcattcaa aaaaggacgg attacattca 3342301 gcgtctcttc attggagttg tcatccataa taaacaattc aaaatctgaa aacgtttgtg 3342361 agagtatgct agaaatggac tttgccacat aatcgctttt gttatagctc gtcataatga 3342421 ctgatacttt aggcaaatcc tacacctcct tcttggaact tcacacctga aactatcgtt 3342481 atcttatgtt gcttatgctc aagttgcgct agggatacaa accaatatgc gaaaagtttg 3342541 tgtatgtttc tgaaaaacag cggctgccca gagcgaaatc tgatcggtcc gctgttcttt 3342601 ttcagcataa tccaagcatc agcctcataa ggtgaaagag ataaaaatcg caccagcgac 3342661 taagatcgtt ttccatcgga ggtgagtcat cgcggagcgt tcacctatac atccagaaca 3342721 tgttttgaat ggttttcata aaaaggagga acgatatgaa accgaaaaaa aatcaatatc 3342781 agcaaatgca ggcatttgat aatatgcagg ggtatcagcc tcagtttggc gccaacccgt 3342841 acccgcagca aggccaaggc tcacaaatgc agacaatggg gatgcagcca atgatgccaa 3342901 tgcagcaggg acagcaagga caacaaggac agcagggatt tggattcccg ggccagcagc 3342961 agggcggcgg ttttcaaatt ccatcggggc ctacaccgtc aggaccgggc caaagcgttc 3343021 ccggcatgct gcctgttgag gaatcttaca tcgagaatat tttgcgcctg aatcggggaa 3343081 aaacggccac catttatatg acatttgaaa acagcaagga atggggctcg aagatttttc 3343141 gcggcgtcat cgaagctgcg ggccgggatc acattattat cagcgacccg aaatcaggaa 3343201 cacgctacct gctcctgaca atctacctcg attacattac atttgatgaa gaaattgctt 3343261 atacgtatcc atattccatg gcgtcctatt cgccaagata agaaaaaagc caatcactca 3343321 tatgatgagg attggctttt ttgtttatag atatttgacg gctgcgacaa cgatcataat 3343381 ccaagaaata ataaacgcca caccgccgag cggggtgatc gctccaagaa tggagatttg 3343441 cgtcacactt agaatatata agcttccgga aaacagcaca attcccgcaa acatcagcca 3343501 gccggctgtc gtgacactgc ctatgccgga taatttatca gccagaaacg cgacaacgaa 3343561 taacccaagg gcgtgataca tatgatactg cacgcctgtg tgccaaacct gaagatactt 3343621 atcaggtatt ttcccttcta atccgtgagc gccgaatgct ccgagtccca cggcaagcag 3343681 ggcgttaatg gcccctaata tgataaaaac tttcatctat ctctcccgcc ttttcgttaa 3343741 actcatatca tttatcttat cgcacctgca ccaaaattca atgtttgttc tccgttgaca 3343801 cgagattgtc ggattttctc ctgcgccaaa gctggaactg gtcagctgct attgcagcaa 3343861 gcgtccctaa tacgagcccg ttgcttaata gagaaataaa taccggatgc aatcccttta 3343921 acgcagtttc aggaacaaac atgataccga cccctgtcag cagtgagata ccgatgatag 3343981 acctcaccct ttttgattct tctttctcat atgaatcaaa ttcggcaaag gccagaccgc 3344041 ccattgcgga gaacacaaca aaattcaccg caaatccaac gggtgacggc aggctcgcaa 3344101 acgtattcat aaaaaacggg atcacgctga tcacgataac cagaatactg ccgagcataa 3344161 acggtttttt agaaggcatc ttggtcgttt caataaaacc tgcggctccc gaaatcggaa 3344221 caggcgcaat agctcccgtc aaaccgctaa gcagatggct gaatgaagct gcaaaaccgg 3344281 catggcgttc atgatgcttt ccatcaggct gtttgctgaa ttttttcatg gcgatgtcca 3344341 cgaccttcat gctcgccagc atattcacga tcagcaagat ggtaataaaa atagaagtga 3344401 tgatcaggcc gctgttaaat aacggggtcc caaaaggaaa cagggaaggc agctgaaaca 3344461 gccggtccgg catttcaatc ggctttgcgg ctccggcagc cgcaaacagc acccacccgc 3344521 cgaacaaggc taataaaata gaatattgct taaaaaacat gatgttcgaa tttgtcatta 3344581 taaaagcggc agcgatcaca acaagcgcca ggccaaatac aagaccgtcc accccgtcct 3344641 gtcgataacc gattccgaga attcctttta taatgggctg actcagctgc atgacaagaa 3344701 gcaataaata gacgcccgtt acaaccggag taaacaattt tgcaagtctg tcaatgacct 3344761 tgaaaacact taacaaaaag aaacatacag cgcttacaag aagagctccc tgcaaacccc 3344821 gcagtgtgtc tccatatgtc gcaaacacag ttcccgtcag ccctgcgtaa atcgtataca 3344881 ctccccacca caagccggct gggctttcat tgatcggcag tctgtggcct ttcaaacact 3344941 gaatgacggc ggcaattccc agtacaaaaa aagtgctttg aatcaatctt gcagaatctg 3345001 agtgatccag atgaaacgac tgggcaaccg ccaccggaac aacaatcgcc gcagcaataa 3345061 taaacgctgt ccattgcagc gcgccaagaa ccaatttcac gtaagctcaa cctctctctt 3345121 taaaaatcaa ataaagactc tccgtttcca tcctcttcct gcttctcttt ttcttgcttt 3345181 cgatatttgt ttaatcccgc gctccccatc attttttcca tcatcagctg gtctgtcgat 3345241 ggcggcgcgg cgggacttgg cgtaacgctc ggctgtatgc ggggcgcgct cgcgttctcc 3345301 ggctgatcaa gcacgacatc acacagagaa cggacaaccg ctacataacg cttcagctcc 3345361 tcatcccgtt cagccgtttt tgcttttttt agctcttctt ccatcttttg aatcaaagca 3345421 gatatatgaa tgttcatgaa gcaccctcca aaaaaataaa tgttgtcttc ctgcatttta 3345481 tcaaattcct gctgaaaacg cagatatgag tttgttattt tttctgacaa accttgcgcg 3345541 attgacaagc agaagagatt tttcacataa taaatcacca taccttacaa aaaggagaaa 3345601 cggaatgaac agcatcccct ctatcatcag caagcataaa gcctattttg cggcgggaca 3345661 tacgagaccg cttgaatcga gactgaacat tttgcgaaag ctgaaacaag ccgtcagaac 3345721 tcatgaagcc gatctcatag ccgctctcta ccaggatctc cataaatccg agcaagaagc 3345781 atactcaaca gaaatcggaa tcgtcttgga ggaaatcagc tttgtcatga aacggctgag 3345841 aaaatggtcc aagccgaaac gagtcaaaac gccgttgact catctaggct ccaaaagcat 3345901 catcatccct gagccgtatg gaaccgtttt ggtgattgcg ccttggaact atcccttgca 3345961 gctggcgctt tctccgttga ttggcgccat tgcggcgggg aacacggtcg ttctcaagcc 3346021 atcagaatat acgccggctg tttctgctat tctttccaaa ctcatcagca gcgtttttcc 3346081 aactgattat gtcgctatgg cagaaggcgg gcccgatgtc agcacagcat tattacagca 3346141 gccctttgac tacattttct ttaccggcag tgtagctgta ggaaaaatcg tcatggaggc 3346201 cgccgccaaa caattaattc ccgtaacctt ggagctcggc ggcaaaagtc cctgcatcgt 3346261 ccataaagat gctgacattc agcttgccgc caaacgcatc gtcttcggga aatttacaaa 3346321 tgcgggacaa acctgcatcg caccggatta tttatttgtc cacgaggaca tcaaaacgaa 3346381 gctcacagaa gaaatgaagc gtgcgatcag agaattttac ggccctcagc cggaacggaa 3346441 tccacagtac ggcaaaatcg tcagtgagcg ccactatcag cggctgctca gctttctgaa 3346501 tgatggcatc ccgctcacag gcggacaatc tgatcccaat catcacaaaa ttgcgccgac 3346561 cattctcgaa caagtgagag atgactctcc agtgatgcag gaggagattt tcgggccgat 3346621 tcttccgctc tttacatacc gcaatatcgg ggaagtcatt gagaaagtcc aatcgcgccc 3346681 taagccgctc gccctgtatc tcttcaccac aaacaaagaa attgagcgcg ctgttttagg 3346741 aaatctgtcg tttggcgggg gctgtgtcaa tgatacgtta atgcatgttg cgacgccgta 3346801 tttgccattc ggcggcgtcg gggaaagcgg catcggcagc tatcacgggt ttgacagttt 3346861 taacacattc acgcacaaaa aaagcgtcgt caaacaaacg aaccgtttcg acttcgcatt 3346921 tcgttatcct tcctccaaaa acgggctgcg aatgattcga aaaatactca aataaaaaag 3346981 cgcagatcac ctgcgctttt tacaaatcct taatacacca atcaatcggc gcctctccca 3347041 ttttctccaa ataggcattc gcccgggaaa acggtctgct cccgaaaaat ccgtttctcg 3347101 cagaaaacgg gctgggatgc gtcgattcaa tgataaaatg cttggaggtg tcgatccgtt 3347161 cttttttcat ttgagcatgc cgtccccaca aaataaagat aaccggccgc tctctttcac 3347221 tcagcacgtc aataattcgg tccgtcagtc gctcccagcc ttttccctta tgggaattcg 3347281 cctgtccgcg ccttactgtc agcacagtat tcagcaaaag aacgccttgc tttgcccagc 3347341 tcacaagcga cccgtgattc gggatgctgc acccgatgtc ctgctgcagc tcaagaaaga 3347401 tattttttaa cgaaggcggc tgctttacac cgggcttgac agagaagctt aaaccttgag 3347461 cctgtcccgg cccgtgatac ggatcttgac ccaaaatgac gaccttgaca tcatcatatg 3347521 atgtataatg cagcgcgttg aaaatatccc ggctgtccgg ataaatcgtt tgctccgcgt 3347581 attccctctt cagcatctct ctgagctctt gataatacgg tttctcaaac tcttccttta 3347641 gctgattcca ccagctgtct tgtaaaagct gtttcaagat tcaggcctcc ttacgaacga 3347701 tgaagtctgg aatagacagg ctcgccatcc caaaccattt cactttttgc ttcccgcctc 3347761 ttcatctcag gctcttcaag caggacggca aagtttttcg tcggcagctc cccgagtccg 3347821 tgcttttcac ttaaacgatc caaatattgc ttccgcttgg cgccaaggtc agcagactga 3347881 ttgtctcccg cgtcactgaa ggcataaatc acgctggcgc aagggacacg cttcacccgg 3347941 taatccttgg ccgcgcgcaa ataaaaatcc cagtcccagt aattgtgcac atcagcatcg 3348001 aaatacccga tttcatcatg cagaaaacgt ctgtacatgc tgcccgacgg cacgtatgta 3348061 gaaaacactc tcatatcctc atagtcagcg gtataagcaa acaatttccg tgacactgga 3348121 taccttgttc cgtttttctc ttcaaacgaa actatttccg catcagaatg aacgaagtct 3348181 gccgtttcta tttcctttgc cattttctcg atatgccctg gcgtaaagaa atcatcgtca 3348241 tcacacagca taatgcaatc cccagacgcc tcttttacac cggcatttct cgcagccaca 3348301 tgccccgagt tcttttctaa attgatgaca gcaatcggca gctccggata aagtgctttg 3348361 accggcacga ccgattcccc ggcatcattc acaataataa tttcatacgg catcaaggtc 3348421 tggcgggaaa tcgactccaa aagctcacac aaagccggaa tccgattata ggtcacaatt 3348481 acgatagaaa tcttcatgat gctctccttc tcattttcat agtcatgtac tattaaaaca 3348541 tatattggac gggagatcag tgggaatatc ctactgaaac ggcatactac aatgatagaa 3348601 acagcaaagt ggctccgatc agaagcacca tgatcagcat cagatctcca aagacatgaa 3348661 agatatcttt catgcggacg ccattcggaa ggataagacg ccacagctta gattgataga 3348721 ccggcagcag caccagtgca taagaaagac acaaaaatgt aaaagccggc ggcacaaaag 3348781 cacagcctgc atcgtcccaa ttcatcatga tgtctttcat actagatcca tccaataaaa 3348841 acaaagatat catgagggct agcaacacaa aggaccccaa ttgaacctca aacaggcgca 3348901 ttttctggtt atatgcaaat cggaccgccc aaaaccagac ataagcatat gaacatagca 3348961 gcgtaagaat ggcacctgct gtaaagacga catcaggcag ccgatcaagc agaaaaacaa 3349021 aaggcaagct ggctgccata gccaagagca tgcagccacc agtaaacaaa aatactgccc 3349081 catgagctac aaaaccatat aaacaagagc taatcctcac gacatacacc tcctttacat 3349141 agaaattcta tgtatatacc taaaaaatca gacaagctga cgcctgccaa tataacagcc 3349201 cattcggcca aataacggaa ataacagcgt tgcaaaagca caagttccaa caaaccaagg 3349261 tgtcaacaag gattgaaaca gcgcagcagg aattacattg aatagaaaaa caagcataaa 3349321 aatgacgttt ggcaccattg agatcagaat cgtatgtaga acaagctttt ctccgcgttt 3349381 tccaaactcc ttcacgcctt gatacccaat cagcacccag tagatcatat atgcagctaa 3349441 gatcagccaa acagaaacag aaatgccttt ccatactgct tgaacaaacg gtgattcaag 3349501 ccatacatgc attattgtaa tcgcaatgcc gacagcgaat agggcactgt tacagaaaag 3349561 atggaacatc aaaaacgcac gaaacgttac tggctgtatt ttcttaaacg aagaaacaat 3349621 gtcagttggt gttccaaacg cctgcaataa agtctgcata gcttcctcct cactctttcc 3349681 ttcctgaaaa gagcgaaaca gatgatgttc aatatggctc tcaatctctt ctatcatcgc 3349741 ctcaccctca ggaagccctt taagcccgct tttgatttcg gatacatatg tttctttatc 3349801 cattttgtcc gctccacttc agtattcggt ccatcatggc tgaaaatacg ctccattcct 3349861 tcgtgcgttc cgccagcact tctttgccct cgtctgtaat ccggtaatat ttgcggtccg 3349921 gtcctttctc ctgcttctcc cagtaggaag aaatataccc ttggcgttca agcttgtgaa 3349981 gagaaggata caaggtccct tctttcatct gcagttcatt tccgctgcgg cttcccattt 3350041 cttttacaag ctcatagccg tacatcggcc gctcgttcag aagcgtcaat accaatataa 3350101 ccgtgcttcc cttaaccagc tcacgattta acatctcaaa acccctacct agttttctta 3350161 tgtagcattt tacgaaagcc cgttgagatt gtcaaatgat tcctatagat cttctatatt 3350221 gtgatacaga gaaaatctaa ctataatgaa agacaaaaca tgatggaggt tcaagacatg 3350281 tctatgcata aagcactcac cattgccggc tcagattcca gcggcggtgc tgggattcaa 3350341 gctgatttaa aaacatttca agaaaaaaac gtatacggga tgaccgcctt aacggtgatc 3350401 gttgcgatgg acccaaacaa cagctggaac catcaggtat tcccgatcga tactgataca 3350461 atccgcgccc agcttgcaac aattacggac ggcatcggcg tggacgccat gaaaacagga 3350521 atgctgccaa ccgttgacat tatcgagctt gcggcaaaaa cgatcaaaga aaaacaatta 3350581 aaaaatgtgg taattgaccc ggttatggtt tgcaaaggtg ctaatgaagt cctttatccg 3350641 gagcacgccc aagccctgcg tgagcaattg gctccgctag ccactgtcat tacgccaaac 3350701 ttgtttgaag ccagccagct cagcggcatg gatgaactaa aaacagttga cgatatgatc 3350761 gaagccgcga aaaaaattca cgcactcggc gctcaatatg tcgtcattac aggcggaggc 3350821 aaactcaaac acgagaaagc cgttgatgtt ctctatgacg gagaaacagc ggaagtcctt 3350881 gaaagcgaaa tgatcgatac gccttataca catggcgcag gctgtacatt ctcagcagcc 3350941 gtgacagcgg agcttgccaa aggtgcggaa gtcaaagaag ccatttacgc agcgaaagaa 3351001 ttcatcacag cggccattaa agaatccttc ccgctaaacc agtatgttgg tcctacgaag 3351061 cattctgcac tgcgcctgaa tcaacaatca taaaaaaagg ggctgcctta cagagaggca 3351121 gcccttttta aatcaccgaa gacttttcac agaaaaaact gccgatccca tcggcagcct 3351181 gtttatttga tttttaaatt gtttgcagat ttcctcaaaa atgtttctat cgactgaaca 3351241 aaaagtgcat attccttcat ttgttcatat gcccgcgtga gaatttccgc cgtttcactg 3351301 tgcggcgttg ttccgccaag catttttttc agctgaagca gcacatcctt atattcttct 3351361 cgcttatctt caacttggtt agcagccttt tccaaacatt ccggtgttat cttctgttca 3351421 tgtatattca agaaaacaac tccttttaca gaaaaaaata gtaggttatc gttgaagaat 3351481 agcacagatg gctcagattt cacataagaa aatagaagga ttttctacat aagtgtccaa 3351541 attccgacat tcatttcaga tttcccggtc gcactggctg ttacttcatg atttcccggg 3351601 aaaggaaaat atcttgcact caagacctct tctccgttat tgataaagat ttccacagat 3351661 gacgcgtcga gaaacatgtg tacggtatgc aaatccttga tgcggcaatg tctcgcttct 3351721 gttctttttc cgtcaaagct ctttcgttcc agcgtaacaa tcccctcgtc tttatggaag 3351781 gaaaacgtag ccgttccgcg gatactgatt gaaaagccag actccgtatg aatgtcttcc 3351841 agtagaatct cagttctttc aggtttttcc actggaagcg caccagatga tccatgcatg 3351901 ttgatgtgta tttttttctc atttctgcgc atggctttta gctcaggcag cggctgctga 3351961 atcagcttct gtcctgaaag cgtcagctgt ctcggcagcg tcatgcagtg aatccagtgg 3352021 cagtcaatgg tcggatggga cccttcatcc tgatcaggca ccgccatcca tgcaaataaa 3352081 atccgccttc cctgatcgtc ttcaagtgtt tgcggcgcgt aaaaatcaaa accttgatca 3352141 agctccgtaa attcaccatg cttcagttca ggcttgttat aatcgaggcg gccgacaaaa 3352201 taacctgatt gatatacgtt ctgataacgg aaaccgtcag cctcaagccc ttgaggcgaa 3352261 acaatcagca catccgatcc ttgaagggaa aacaaatcag ggcattccca catgtatcca 3352321 aaatcgtcca gcccgttgaa gcccgcgccg gttatcgggc caagaaatct ccactctgtc 3352381 aggttatcag aagcaaacaa cacagcctgc cctttcaaat tctctgtttg cgcaccaatc 3352441 accatatacc atgtgccttc atgctcccat accttcggat cgcgaaaatg cgccgtatat 3352501 ccttccggaa ggcgggcgac gacacccttt ttctcaaagg acagcccgtc gtcagaaaca 3352561 gcaaggcatt gatacgtttc ccgatttcca tcctgatccc tgacatttcc tgtgtaaaaa 3352621 agatagagcc gatcgtcttt cgtgacagcg ctgcccgagt agcagccgtt tttatcaaac 3352681 caatcactcg gagccagcgc aatctcttcc cgcttccaat tcacaacatc ctgtgtcgta 3352741 taatgccccc aaaattttgc gccgtgcccc gtctgaaacg gctgccactg aaagaataca 3352801 tgatagctgc ccttccaata aatcacgcca ttcgggtcat tcagcagccc aaccggcggc 3352861 atgatatgaa aatgctggcg gtgcggatcg ctgttagcga tgggctcttt tttctccact 3352921 tcttcataag cccggcgacg aagctcctgg tcatgtgctg tcattttttc ctctcctcat 3352981 cctcattaat cttcatgaca aatgctgcaa tgaacgctga cactgccgca atcgccatgc 3353041 caatcagata gtgaatcaag ttgctgaagc caaacggagc cgcaatggcg atcatcggaa 3353101 ttcccgttaa cccgtaagcg tttgcagcta catgtgtaaa gacgacatat gccccaccca 3353161 atgcgcctcc gatcatcgcg gcgataaacg gttttcggta gcgcagattg actccgaata 3353221 tgacgggctc agtaatgccg agaaaagcgg aaaatgctgc cggaagcgcg atttcttttg 3353281 tctttgcctt tttcgccata aagaagacgg caagacctgc cccgccctgt gcgacattcg 3353341 ccattgacca gatcggcagc aagtagtttt tgcctatatc tgcaattagc cctgcctcaa 3353401 tcgcatggaa gctgtgatga acgcctgtca gcacgatgag tgaatacgtg cccccgaaaa 3353461 tcagacctgc gacaaaaccg gcatggtcat atacataagt taaagcaacc gtaatgccgg 3353521 agccaagcgc tctgcctaga gggccaatcg cgataaaagc aacaaacccg gtgacaatca 3353581 cagtaacaaa tggtgtaaca agcaaatcca ccgcatgtgg aaccactttt ctcgtccatt 3353641 tctctacctt gctcatcaca tacaccgcaa gcaggacagg gataacagtt ccctggtagc 3353701 cgagaagagc gatatcaaat ccgaaaagat gcatgtaatc aggtgtcgct tccgccaatc 3353761 cccatggatt taaaagattc ggatgaatca tgattccccc gatgaccgct cccaagtatg 3353821 gattgctgcc aaactctttt gaagcgctga ccccgattag aatcggcaag aaaatgaatg 3353881 ctgcacttga aaacatatca agcagctgca aaagcgcaga atccttgctc atccaatgaa 3353941 acgcattgat catacccagc aatcccatta ataggccgct ggctacaata gctgggatga 3354001 ttggaacaaa aatattagaa agcgttttcg caaatctcgc agcgggattc agcttttctt 3354061 ttgccgcatc ctgatgattg acgtgttctt cacgctcgat atcagcttct ttagaaaagg 3354121 catcgaatac tttattcaca aggcctgttc cgaaaatgat ctggtactgg ccagagctgc 3354181 tgaaagcccc tttaacgcca tcaagctctt ctacttgtgc ttgatctatc tttgattcat 3354241 ctttcatcac taaacgcagt cttgttgcac aatgagccgc gctgataata ttttctttcc 3354301 ctccgagaag ctcaatgagg cgttttgcag tctctttgta atccatctat ttctccccct 3354361 tttatttaaa caaaaaagac ctaaaattcg ccaacgaata aaggacacag cgatcctttt 3354421 tcatttacgc aaattttagg tcttgcctgc tttaccagtc acaatcccgc ttattcagat 3354481 taagaatacg ctttcatcat aaatcatgat agcgttttcg tcaactattt ttttagttaa 3354541 atagtttgat ataacatgta gacaaaaatt cgtaaaaatt aattgtgaaa tacttcacaa 3354601 tatcgtgcta tactatgctc aatcatgaaa gaaagcagga aaagacaatg gaaactcaag 3354661 cattacaaaa ggttgaacag tatgctttga aaaaacaaaa catattcgct tcaagcaaaa 3354721 tccgttatgt gcttcggtcc attttggcca gtatatttat tggttttggc attacagccg 3354781 caagcaaaac aggcagctat ttctttatgg ctgattctcc gtttgccttt ccggcagccg 3354841 ctgtcacttt cggggccgct attctgatga ttgcttacgg aggcggagat ttatttaccg 3354901 gcaacacctt ttatttcacc tataccgcgc tccggaaaaa aatcagctgg cgcgacaccc 3354961 tatacttgtg gatgtcaagc tatgccggca atttaatcgg cgccattctg tttgccatcc 3355021 tgatcagcgc gacgggactt tttgaggagc cttctgttca ttcctttttg attcatttgg 3355081 cagagcacaa aatggagccg ccggcttccg aattgttttt cagaggaatg ctgtgcaatt 3355141 ggcttgtgtg cctcgccttt ttcattccaa tgtctctcaa aggggaagga gcaaagcttt 3355201 ttaccatgat gcttttcgtt ttctgcttct ttatttccgg ctttgaacac agcattgcca 3355261 atatgtgcac attcgccatc tcgcttttga tcgagcaccc tgatacagtg acactgatgg 3355321 gagcagtcag aaacttaatc cccgttacgc tcggcaatct gaccgcggga atagttatga 3355381 tgggctggat gtactacaca ctgaatcctg atcaataaaa aaacttccag agatcactcc 3355441 ctgcaagtca aagcggttat tccgagagat cttgaagacg ctggacatgc agcgtgatat 3355501 agccggcctc ggattccggc aaatgtaatt gatattcatt tttcaaaaac tccgccagct 3355561 ccagcgcaca ttgataggcg aatgaatact ttttttggat gaaataaagc atctcctcgt 3355621 ccatacgatg gagcgcttca tttgattcca accggctgac cgcgtatcgc aaatgcgtga 3355681 caaggcgttg ataggaaatg ctgttttcat ccacctttcg attaaagtat tgttttattt 3355741 tctctatcat ttctttgatc atggtcgtat gcttcagcgc tgaatacatg ctctccgcat 3355801 ccatcttcgc cgtatggatg tgaagggcaa tataacccgc ttcatcttca ggcagagaca 3355861 cgcccaatgt ctcttttaca tgtccgatcg cccacaggcc gatctcatat tcttttttat 3355921 agagcgcctt tatctcatgc agcaatttat tctgcacaag cagcccattt tgaatccttt 3355981 cgatcgcaaa ggacaaatgg tcggaaagcg cgatatgaat gtgatcgctc agcggcgccg 3356041 cgagctctcc ttccgcatag ctgatgatat cctcagctat ttctatatgc tcctccggca 3356101 gtgtttgcag gatttgtttg aacttttcat tctcgtcgcg cacgacaaag atcttttcca 3356161 ctttattcat agggatgaga tcatttttct ttttttgaaa agcgattccc ggtcccatca 3356221 cgattttttc ctgatcatcc tcttttatta aagccgcatt gttgtttaat actttataga 3356281 ttttcaagag gttatctctc ccgccaattt gcttttgact gggattttac ctccttttga 3356341 ccgccatgta aagatgcggg cccgctctct cctgctttgg cgattccttg aaggcttgca 3356401 aacatcttct tttataaagc gcggcggctt tcgctttctg cttttcttcc tcattcacag 3356461 ccatccgcca ttcataaaac gaaacgagtc ctgcggcctg cacagccgcc tttctttggt 3356521 atgtacgctg agccgaatag accgcggcag ccgcagtttt tctgtccggc gtcacccagt 3356581 tcatcaaaaa gaccatccac acccgtaaag atacaagcaa acgtttcata gaaaaacatc 3356641 cctccgcttc tttttggcag gcagcctttt tagcagcccg ttttctcagc cgcagcccgc 3356701 aagaaaagac ggccgatttc ttttctcgca aactagcggc tctagcaaaa ctcatgactc 3356761 tatgatagac cgtggaaaga gaattctttg tcacaatatg agtgaaaaaa ccaactagtt 3356821 tttagaagtt ttgttgaaag ctgaaagaat tgaaatgaaa attggagaac cgctttgaaa 3356881 actttataca caagttatcc caaagataag aacaacttaa tcacaagaga tatccacatg 3356941 tccacaaact ctatctatat tttgtatacg aacgtatatt cctaactata tatatacaca 3357001 ggtttattca cttatacaca gggttctgtg tataactcct tcgttataca caaacaaaat 3357061 ccaataaatg gtccaaatga cacaaggatt tttttgaatt ttcaagaaat atatactaga 3357121 tctttcacat tttttctaaa tacaaagggg gaaacacatt gaaaaagggg atcattcgct 3357181 ttctgcttgt aagtttcgtc ttattttttg cgttatccac aggcattacg ggcgttcagg 3357241 cagctccggc ttcttcaaaa acgtcggctg atctggaaaa agccgaggta ttcggtgata 3357301 tcgatatgac gacaagcaaa aaaacaaccg ttatagtgga attaaaagaa aaatccttgg 3357361 cagaagcgaa ggaagcggga gaaagccaat cgaaaagcaa gctgaaaacc gctcgcacca 3357421 aagcaaaaaa caaagcaatc aaagcagtga aaaacggaaa agtaaaccgg gaatatgagc 3357481 aggtattctc aggcttctct atgaagcttc cagctaatga gattccaaaa cttctagcgg 3357541 taaaagacgt taaggcagtg tacccgaacg tcacatataa aacagacaat atgaaggata 3357601 aagacgtcac aatctccgaa gacgccgtat ctccgcaaat ggatgacagt gcgccttata 3357661 tcggagcaaa cgatgcatgg gatttaggct acacaggaaa aggcatcaag gtggcgatta 3357721 ttgacactgg ggttgaatac aatcacccag atctgaagaa aaactttgga caatataaag 3357781 gatacgattt tgtggacaat gattacgatc caaaagaaac accaaccggc gatccgaggg 3357841 gcgaggcaac tgaccatggc acacacgtag ccggaactgt ggctgcaaac ggaacgatta 3357901 aaggcgtagc gcctgatgcc acacttcttg cttatcgtgt gttagggcct ggcggaagcg 3357961 gcacaacgga aaacgtcatc gcgggcgtgg aacgtgcagt gcaggacggg gcagatgtga 3358021 tgaacctgtc tctcggaaac tctttaaaca acccggactg ggcgacaagc acagcgcttg 3358081 actgggccat gtcagaaggc gttgtcgctg ttacctcaaa cggcaacagc ggaccgaacg 3358141 gctggacagt cggatcgccg ggcacatcaa gagaagcgat ttctgtcggt gcgactcagc 3358201 tgccgctcaa tgaatacgcc gtcactttcg gctcctactc ttcagcaaaa gtgatgggct 3358261 acaacaaaga ggacgacgtc aaagcgctca ataacaaaga agttgagctt gtcgaagcgg 3358321 gaatcggcga agcaaaggat tttgaaggga aagacctgac aggcaaagtc gccgttgtca 3358381 aacgaggcag cattgcattt gtggataaag cggataacgc taaaaaagcc ggtgcaatcg 3358441 gcatggttgt gtataacaac ctctctggag aaattgaagc caatgtgcca ggcatgtctg 3358501 tcccaacgat taagctttca ttagaagacg gcgaaaaact cgtcagcgcc ctgaaagctg 3358561 gtgagacaaa aacaacattc aagttgacgg tctcaaaagc gctcggtgaa caagtcgctg 3358621 atttctcatc acgcggccct gttatggata cgtggatgat taagcctgat atttccgcgc 3358681 caggggtcaa tatcgtgagc acgatcccaa cacacgatcc tgaccatcca tacggctacg 3358741 gatcaaaaca aggaacaagc atggcatcgc ctcatattgc cggagcggtt gccgttatta 3358801 aacaagccaa accaaagtgg agcgttgaac agattaaagc cgccatcatg aataccgctg 3358861 tcactttaaa ggatagcgat ggggaagtat atccgcataa cgctcaaggc gcaggcagcg 3358921 caagaattat gaacgcaatc aaagccgatt cgctcgtctc acctggaagc tattcatacg 3358981 gcacgttctt gaaggaaaac ggaaacgaaa caaaaaatga aacgtttacg attgaaaatc 3359041 aatcttccat tagaaagtca tacacacttg aatactcatt taatggcagc ggcatttcca 3359101 catccggcac aagccgtgtt gtgattccgg cacatcaaac cgggaaagcc actgcaaaag 3359161 taaaggtcaa tacgaagaaa acaaaagctg gcacctatga aggaacggtt atcgtcagag 3359221 aaggcggaaa aacggtcgct aaggtaccta cattgctgat tgtgaaagag cccgattatc 3359281 cgagagtcac atctgtctct gtcagcgaag ggtctgtaca aggtacctat caaattgaaa 3359341 cctaccttcc tgcgggagcg gaagagctgg cgttcctcgt ctatgacagc aaccttgatt 3359401 tcgcaggcca agccggcatt tataaaaacc aagataaagg ttaccagtac tttgactggg 3359461 acggcacgat taatggcgga accaaacttc cggccggaga gtattacttg ctcgcatatg 3359521 ccgcgaacaa aggcaagtca agccaggttt tgaccgaaga acctttcact gttgaataag 3359581 aaaaagccct gccgattcgg cagggctttt taaagatcag tcagcaaacg cctcctgcaa 3359641 taagcgatac gatcggagct tatcttcaaa atgatgcgtg atggtcacca ccatgatttc 3359701 ctctgtttca tacgcgttac tcaaagctaa cagccgctcc ttaacctgtt ctttcgtacc 3359761 aacaatcatt cgatttcgat tatcagcaat tcgtctctgt tcataaggag aatacgtatt 3359821 tttccgaaca gcttcatacg aaggaactcc ctctaaagga ataccctgct ctcccgccaa 3359881 aagtgtaaaa tcaagcacag ccccaagctc ctctgccttc tcctccgtgt cagcacaaag 3359941 aacaaaaaca gcaactgccg ctcgaggcgt atctcctaac acagacggtt tgaatcgcct 3360001 cttatactgt ctgacagtac cctctccgcc ctctccattg ataaaatggg caaacatata 3360061 gccagcgcca gattcagctg cgagcagcgc gctttctcca gatgagccga gcagccacac 3360121 atccggagcc gttgaaatat gcggcgcagc ggtcagattc ggaaaacggt gtttgtcatc 3360181 cgccaaatca tgcaaataca tggtcagctc cttaatttgc tgcggatact gatcagcatt 3360241 gcgcttacca ccgtcattca gcgcccatga tgcaatcggc attccccccg gtgctctgcc 3360301 aagccccagg tcaattcttc ctggtgtcag cccctccaga acacgaaagt tttcagctac 3360361 tttataagca ctgtaatgcg gcagcatgac tcctcctgat ccaacacgaa ttcgctttgt 3360421 tttcgctgct atatgactga ttagcacctc aggactggac cctgccagcc gttttgaaaa 3360481 gtgatgctca gaaacccaaa atctcttata tccaaggtcc tcagcagctt gggcaagcgc 3360541 aacggtttgc tgtaaggccg tttctgcatt gctgccctct gatactggag attgatctaa 3360601 tatacttaat gaaaccatcc ctaccacctc atcctcatcg tatcactgat cccctatttt 3360661 ttctccaaag ccgctcacac tgcttatcag tgtcccctat cattcgccat ttatttgtga 3360721 aagcatgtcc ctatttgtcg gaatatgtta cacgtgaaac ataaaaaccc ctccagacgg 3360781 agaggtttgc tttagttttt attaaagccc ttttctttca cgtagtcatt taaatacgta 3360841 cgcggctttt gcttcataaa gttcagtatt tgatcggacc acgtttcttc ccgcttcccg 3360901 tttgttcttt ctctatagta atcagaaatg gttttgtcat acgtattcat agtatgacgg 3360961 aaatcgtctg tgttcacatt atacgtattt tcatgataaa cggcctgctt tggcaatctc 3361021 ggttttttgc cggaaaggtt cgcaggatgg cctactgcca gtccgaaaag cgggagcaca 3361081 tggtcaggcg tttgcagcac ctctgtcacc ttgtccaatt cattccgaat gccgccgata 3361141 tagcaaatgc caagccccat ggattcagcg gcaatgctca tattttgcgc tgccagcgcc 3361201 gcatcaatca agctaaccat aaacatttct gtattctcga gcagctcaga aatatgttca 3361261 cctttttcct cagccagttg ttgatggcgg tacaaatccg cacaaaatac aaaaaagtgt 3361321 ccgttcttct caacgtaagg ctgattccca gcaagcacgg acagctcacg ttttttctca 3361381 ggatcagaaa ccccgataat cgaatatgcc tgcacatagc tggatgtaga cgcagcctgc 3361441 gcacttttca ctaatgtatc aatttcttca gctgtcaaaa gctgatcagt aaaagaccgg 3361501 attgaccgat gattcaaaat ggtttcgatt gtgttattca tcacaaaaac ctccttatca 3361561 ctttttatca tatccgaaaa aaagtgatct caaaagtgaa atgctctgca caaaaaaaga 3361621 cagcctctgt aaaggctgtc tgcatatcaa gaattaaaaa gataacttct gtatttcgtc 3361681 agctgcacac ttgcattata tacaatccca aatccgatta acgtggaaag tgtcgagctt 3361741 cccccatagc tgacaaacag cagcggaatc ccggtaacag gcataatgcc aatgttcatt 3361801 ccgatattct ggaatgtgtg gatcacaatt aacgccgtat agccaacgca aaagaaagaa 3361861 gcgaaacggt taaacggatg tattttgtct atcagaacaa caagcctgta gattaaaaag 3361921 aagaacatga tgacaacaat tgcacagcct ataaagccaa atgactcacc tattatagaa 3361981 aagataaagt cagtcgtact ctctggaaca taaaccttca aattagaaat accattacct 3362041 aaaataccac cagatcctat tgccatgatg gcctggtcaa cttgccagct gtcatttgaa 3362101 tcttcctgtg tctcatttga agcagacacc caagaagtga cccgcttaat ttgataatcc 3362161 tgtattccaa ctgatttagc aacgtcagga aagtttatca ttactaataa aattaatgaa 3362221 atgagtaaga tacctgaacc agctatgatc gcaatcaatt tccaatttat ccctgacata 3362281 aaaaccatta caagaacgat aaacatacat attcccgcag tcccagcatc ctgcatcagg 3362341 ataagaccta caggaataac tgcgacaccc gcaatcttta ataacaagtg gatatcatcc 3362401 ctaagcgtcc gaactccttt aggatttgct tttccaataa ctgaagcaag catcataatc 3362461 aaaccaacct tcataaactc tgacggctgt attgttattc taccgatcct aaaccaactt 3362521 tttgcccctt taataacagg tgcaatagac tcgggactga ttttaagaat aatcaaagat 3362581 aaaataccaa tgataaaaat atataaactt aacttttcaa gctgttctaa atcaaagtac 3362641 aaaagaactg taatggctac agcccccaaa agataaaaca caatttgctg aatccaatcc 3362701 gtgttcccat actgcccaaa ctgaccggca gcatatattg atactacgct tataataaaa 3362761 aacacaccaa atataaaaat caaatccccc tggtaaaagg ggctttgctg tttcttatat 3362821 cgactcattc tatcccgcct tacattttca tcggaaaatc actaatgttt attatacatg 3362881 aaccacgttc aagatgacac gtgaagctcg cttcctttta tgttttttca gcatttgcgg 3362941 cgctttttca gctacacgaa atatgacgta tcataaaccg aaatgtttcg attgacacaa 3363001 aacttttcaa atgaaaaaaa cgccatacca atagaatttg ttaaaaaacg aatgcgataa 3363061 tgtgttatgt tcccaaataa tgtgatacct catatagaaa tagctaaaaa ttcagagccc 3363121 catgcccata cattctccta gcacattaaa cgaaaaaata agacgataga tccagtccat 3363181 ttctgcaaaa acacgtatca atttctggaa aacatggtat aataattgta acagaatgtt 3363241 caaaaaacaa tcacaaaaca gacacaactc agttcctcta tttcattttt gtaaacgtta 3363301 tcacaaaatg aaaggagacg ggtatgatgg acatgttttt tgcttactta ttggttgcca 3363361 gcgcaacgcc tctctttatt tggcttgata acaaaaaagt cgcactctca gctattccgc 3363421 caatcatttt aatgtgggta ttcttcttct tttacgcaac agaaagcctt tctccacttg 3363481 gacacactct catgattatc ttgtttgccg ttaacgtcat tgtcgctcat atcgccgcat 3363541 ttatcattta cggccttccg tatcttcgca gaaagcgaag cagctgaaga cagcaaaaaa 3363601 ccctcttcca ctgaagaggg ttttttgtat tattcgttat ggcctgaatg ctctgagtgt 3363661 tcagcgcctc caggaggatt tccgtccata tggtcaccat ggtgatagtg agccgcgaaa 3363721 atccagatgg atccaagtac gataacgatc gcgccaaaga atccgaacag cgtgtttccg 3363781 acttggatcg tgccgttttc gctctctgtc atatgcatga acatgagaag ctgcagcgcc 3363841 gcctgaatga aggcgaagcc gaagataatc caaagttttg ctgatgagct caggtcagta 3363901 tacactgcaa cccatagagc cagcagggtc aaaacgatag acaggataaa acctacaatg 3363961 tgtttccatg gaaagtgact gtgttcagca gatttgtttg ccattttaca gaccccccaa 3364021 tcccatgaga tagacacctg taaagatgaa aatccataca acatctaaga agtgccagta 3364081 caagcttgag ataaagattt tagatgaagt ttgcggagtt aagccgcgtt tcttcaactg 3364141 aatcagaatt cctgtgatcc agaaaatccc gattgttacg tgagttccgt gagttccaag 3364201 taaaacaaag aatccagacc agaacgcact tgtactgaga gccgctcctt catgtacata 3364261 gtgaacaaac tcgttgatct cgcatccgac gaagccggca ccgagaagaa gagtgataat 3364321 tgtccaaatg actacgcctt ttaaacttcc gcggcgcatt tcatgaacag cgatcccgca 3364381 ggtaaagctg ctgatcagca gcaagaacgt cataatcatt accagattga cttcaaatag 3364441 ttcgtctggc aagacacctc cagctgttct gtttttaaga acgaagaagg ttgcaaatag 3364501 tgttgagaac aacacaattt ctgcccctaa aaagatccaa aacccgagaa tattaagtct 3364561 gccggtttca gattgatatt ccataggcgc gttagaattg ccgtgttctg catgttccat 3364621 aactcacgcc tccttattcg gaaatctttc tttccgtctc ttttatttca tcaacactaa 3364681 tgtagtagcc gttgtcgtat tcgaatgaac gcagaaccat gcagagcagg actccgatca 3364741 atccgactac gcccatccag taccattcaa agacaagtcc aaagcctgcg agaccgaagg 3364801 caacagacat aaagaacggt ctgcctgagt tgcttggcat atggattttc ttgaatttgc 3364861 tttcagggta taattcagtt ttttcttctt tcatatgcag gaatgcatct tgagatttga 3364921 cttcaggaag caccgcaaag ttgtaatgcg gcggaatcgc agaagaagtc gcccaatcaa 3364981 gcgtacgtcc cacaccccat gaatctccgc tgatttcacg agtagagtaa cggaagctgt 3365041 agtagatgtt atagcaaagg attaagaatc ctacacccat catgaaagct ccgactgttg 3365101 agataaagtt caatgttgtc cagccgtcat tcggtccgta tgtgtaaata cggcgcggca 3365161 tgccttgaag ccccaagaaa tattgcggga agaaacaaat attgaacccg atcataaaga 3365221 tccagaagaa ccattttccg attctttcgt tcagcttgtg gccgaacatt tttggatacc 3365281 agaaaataaa tccggcgaaa caagcaaata cagtacccgc aatcagcaca tagtggaagt 3365341 gagatacaag gaagtacgta ttatggtatt gataatccgc tgctgccatc gcaagcataa 3365401 cccctgtaac cccgccgata acgaagttag gaatgaacgc aagcgcccac agcataggtg 3365461 ttgtaaagct gattcggcct ttatacattg taaagagcca gttaaagatt ttaaccccgg 3365521 ttgggattga gattgccatt gtcgtaattg agaagaatga gttaacggac gcactgttcc 3365581 ccattgtgaa gaagtggtga gtccaaacta agaaactcaa tacagagatg gcgataatag 3365641 aaccaaccat cgctttgtaa ccaaacaatt gttttcttgc aaagcttgag atgatttctg 3365701 agaaaatacc aaacgccgga agaataacga tatatacttc aggatgtccc caaatccaga 3365761 acaagttagc ccaaagcatc ggcataccgc ctgcttccaa tgtgaaaaag tgagcgccga 3365821 acaaacgatc aaatgataaa agtgctaatg ctactgtaag tacagggaac gcaaacacga 3365881 taataaccat tgtgatcagt gttgtccatg tgaacatcgg catacgcatt aatgtcatgc 3365941 cttttgttct catttttaag attgttacca taaagttgat ccctgtcatc agggtaccga 3366001 taccggcaat ctgaagtccg aggaggtagt agttctcacc cggcccaggg ctcatgtcgt 3366061 tacttgcaag cggcatataa ctcgtccagc ctgcgttcgg agaacctccg ataacgaaag 3366121 aaatattgaa aagcatcgcc cctacaaaga acgtccagaa gctcaggttg ttcaagtaag 3366181 ggaacgcaac gtcgcgggca ccgatttgaa gaggcacaac aacgttgata agaccgatta 3366241 agaacggcat cgccatgaag atgatcatga ttgtaccgtg agttgtaaaa atttcattat 3366301 agtggtttga gtctaaaaaa ctgttattcg gaagcgctag ctgggcacgc atcatcagac 3366361 cgtcgacacc gccacggaat aacataatta cagcagatat aatatacatg attccgagtt 3366421 ttttatggtc aacagtagtt atccattcag accacagcca tttccacttt ttgaagtaag 3366481 tcagaacaaa aataatggca atggttgaaa gcgcaatgga aacttgtgcg cccagaatta 3366541 atgggtcacc agttacgaaa aattcgtccc atttgaattt catgcaggct tcctcctttc 3366601 ctgatcaata tcattcttct gtatcatcag acttcttaaa ttcgtttttc tttacgtttt 3366661 caaacggatc tgttttagaa tgcggtgaaa cggcttgata gccaaggcgt ttgcgcgcct 3366721 ccatcgcgta ctcagcgtct tgtccgtgat caacgtattt caagtgagta gaagagaacg 3366781 ttaattcgtc cacattttca ggaagcatca attcatcata cttctctttt gtcagcttag 3366841 gagcctcgtt ctgagtcttt ttcacccagc tgttaaagtc tttttctgtg actgcattca 3366901 catcaaactc ttggtctgca aaatgttcac ctgtgaagtt cgcgttgcgg ccttcgtaag 3366961 tacccacttt gtcagcctgt aagtattgat ccatcagcat tcctgccatc gcatattttt 3367021 gccctccaag ctgaggaatc catagcgaag ccattgaatc tgcagatgag attttgaaca 3367081 agatcgggcg gtcgacagga atgtttaagt agttgaccgt ttcaatatcc tgttcagggt 3367141 agctaaatac ccatttccag tctaccgaag tagcataaac aacaagaggc tctttgtctt 3367201 ttgttgcttc aggagctttt tctaacgaat atatcgtctg tactgttggc acagaaagtg 3367261 caatgacgat taaaattggg atcactgtcc agactacttc taaaaacgtg ttaccgtgaa 3367321 tttctgggtt ataagatcca ttatctttgc ctttacggtc gcggtatttt actaaaataa 3367381 tggtaaatag aacaaagacg accccgacga taaacagcat aaatccgata gataacagga 3367441 ttaaatcact ttgctgttca gctacaggtc ctttcggatc tagtactgaa gcattgctgc 3367501 atcccccaag gacgaaaacc acagttaaca gcgctaatac aagcaacggt tttaatgctc 3367561 tgaacaagaa gatcaccatc cttcctattg atgtaataaa tctgaagtgc atacttcctc 3367621 aaaatctttt ctctactttg ttatgctatc aaaaacttca cttattagct ttattttttt 3367681 ataaacttca tcccattttc gcttaaatgt cataaaatcg acaaaaattg ctccaacttt 3367741 attcacatct atcgcttaag atgaaaagtt tctagttatt tccgcatata aagtaaagaa 3367801 agatgatgaa gaactaattc tgacaaatta aggtttacca caataaaaaa cttaggtcaa 3367861 tcaaaaattt cattttgtta aactttctag ataggaatta ttttttcctc gtctagcatc 3367921 ttttcacacg gttaccattt taacgcatca aatattgaaa gaaaaggcgc aatgaagagc 3367981 caatatgctc tgaattgtcc gtattttttt atgagagcat ccagttgttt atcttataca 3368041 aaaaagagga atgatataag caaataaata aaaaatagga tgtgttgcat gatgagtttt 3368101 cttatttcac ttatcgtcgc tattattatc ggatggcttg gaagcctgtt tgtaaaagga 3368161 gatatgcccg gaggaattat cgggtctatg atcgcaggtc ttataggcgc ctggatcgga 3368221 cacgggctgc ttggaacatg ggggccgcac ctagccggat ttgccattat tccagcggta 3368281 atcggcgcag ccattgttgt ctttctagta agcctgttaa ccagaaaaag aggataaaag 3368341 cagcagcacc cgaagcgtca gcgctttggg tgtttgtttt gccataaaaa tcgaaaaagc 3368401 ctcaacccta gcggttgagg cttttgactg gtttggcgcc caactgatcg atgaaccttc 3368461 tgaaggcctg ttttccctct gctgtctgct taaatacacc ggcgtgttca aggatgcgcg 3368521 cgaatacatg tcccagctct tcttttatga ctagatctac gttctctttt gttatggttc 3368581 ttttttccat cgtccgaaga gcccactcac tatgctttgc agtgagcgga ttttgttcta 3368641 aggctgtttt cggatcagca gaacatagcg ccgctgccgt ttctttcatt tcctcctgta 3368701 agcggccagg caatatcgcc aatcccatga cctcaatcag gccgatattt tcttttttaa 3368761 tatggtggac ttcttgatga ggatgaaata ttcctaatgg atgctcctca tccgtccggt 3368821 tgttcctcag tacgatatcg agttcgtaca agtctcccct gcgccgcgca atcggtgtga 3368881 ccgtattatg gggcgtatcg cctgtatagg cggcaatgcc ggctttttca tcggaatacg 3368941 tctgccacgt gcggaagata tggtcagcag cttcggcgac atgacccggt tcgtctcctt 3369001 ggagcctgag cacagacatc ggccacttca ctaagcccag cgacacgccg ggataatcat 3369061 ttaattcata aacgtcttcc gcttctgcac gtgccattgg aaaatcatgc gcgccgcctt 3369121 ggaaatgatc atggcttagg atgctgccgc cgacaatcgg cagatccgcg tttgaaccga 3369181 taaaataatg cggatattgg ccaagaaatg acagcagcct ttcaaatgtt tttttgctga 3369241 tctccatcgg ttcatgttca ccttttaaga caatgcagtg ctccggataa tagacatatg 3369301 gcgagaattg caggaaccat tgttcgtcct caaggatgac cggaatgatt ctgtgatttt 3369361 gccgggctgg atgattcacg cttccctcga agccgacatt ttctttacac agcaaacaca 3369421 tcggataatt tgtctgttcc tgctcttttg cagccgcaat cgctttcggg tccttttcag 3369481 gctttgatag gttaatggtc atttccagct cgccatattc ggtcggcacc gtccaatgaa 3369541 catttttggc gattctgtca gtccgtatat aatagacatc ctctgaatat tgatagaatt 3369601 cctttgtcgc ctgttttggg ccgtataatg cttttgtctc ttcaaatttg cgaatgacct 3369661 cggacggggc aggcacaaaa cagcccatca gctttgcgct gagcaggtca cggtacgtat 3369721 ctgtatccgc ttccattcgg ccggtttcgg cagcccattt atagatggga gctagcaagt 3369781 ccggcaggct ttgtgactgc ttgatgctgg tgctggagtt cggctcggga tgtgtgatgc 3369841 ccagcgcttc ataaagacgg tttctcgtat attcccgatc ccagatcgaa atcaattttc 3369901 gttccaggcc atactcaagc agctgttcca gatgttcaat aatactcata tgtcactccc 3369961 cctttagttc tctcgctccc tctccgatat ccgcgacata aaagtccgct cggagccctg 3370021 ttttttcttg atatctgtct ccaaccttct gaataaaatc atcaacgaac tcatctttta 3370081 caatgctgat ggtgcagccg ccaaagcctg ctcccgtcat tcttgatcca attacacctt 3370141 cgtgatccca tgccgcaaac acaagctcat caagttcagg gcatgttact tcatagtcat 3370201 ccttcaatga aaggtgggat tccttcatta actgcccgat ttcatctata ttgttctctt 3370261 tgaacatatg ggccgtctta atagcacgat gattttcgta tacagcgtgc tttgcccggc 3370321 gtctgttcgt ttcattttgg atcaggctgg aatgcgcatc gaaatcagaa ggcttgatgt 3370381 cgcccagtgc ggcaatatcg aggccttttt tcagatcaag caatgcatca ttgcattctt 3370441 ggcgtctcgt attatagctg gagtcagcca atgtcctttt tttgttcgtg ttcgcgatga 3370501 ccagcgcgag gcctgagaca ttgagtttgc tatattcata gtcaagcgtg tcacagttca 3370561 gcagcatcgc atgatgtttt ttccccattc caattgcaaa ttggtccata attccgcaat 3370621 tgacgccgat aaaatggttt tccgcatgct gcgccatttt cacaagctca agcgcatcta 3370681 cttcaggatg aaaataactt tggagcacga cccccatcag cagttcaata gaagcggaag 3370741 acgacagtcc cgccccgttt ggaatattcc ctgaaaatac aatgtcaaag ccatggggaa 3370801 ctgcatatcc cctctgttga aattcataaa tcacgccttt tgggtagttc gcccagtcgt 3370861 cttctttttg atagcgaatg tcgtcaaggc tgcattcctt gatgcctgcg tttctaaagt 3370921 tatctgaata catccggaca agcccgtcgt ttctttctgc aacagcagca tatgtaccca 3370981 ttgtcagcgc gcacggaaag acatgcccgc cgttatagtc tgtatgttct ccaatcagat 3371041 tcactcttcc aggtgcgaaa aaaaaccgta acccctcttt ttctccgaat acacttgcaa 3371101 atatcccctt tagctcttcc cgcatgtgca atcacctttc tggtttttat tttttattcc 3371161 ccttatttct tcatagaaaa cggcagatca tatgctgcag tcctctcata ccccttcttc 3371221 ttttgttttt ttaaagacga gccatttgct cgcaacatag ttgacgacaa caatgaccgc 3371281 gttgtcgagt attttggcca aggtttcatt tgtattgaac tggccgacaa gaatgatcat 3371341 catgcctaaa tctatgccga gagacaggac ccgaacgctg aaaaaagcag tgagctcttt 3371401 cagcaggctc tgcagatcat gtgttttttg ctgaaacaca tataatttat ttgttatgta 3371461 agcaaacagc acggacaaaa tccaagcggc aacagtggcg gctttgtaat ccacattcat 3371521 gatctctacc aatatataaa agctggcgat attcacaatg gttgtgaaaa cccccataat 3371581 gatatacata attatttctc tatacttcac tgatgttcct cgctttctga aaaacttttc 3371641 aaaattcttg gcctctcgtg ctctctgtct aaagtaaaaa ataccgagag tgcgtctaaa 3371701 aagctgcgga aggtggctgg ctggcccaat acatatgatt gtttgatgat tccgtcgagg 3371761 actgcacata ttattttagc cgtatattca ggatcaatac aggcgtcaat cagctttctc 3371821 tccttcagcc acttaatata taacacattt tcttccaccc acaattcgta cagccggaca 3371881 taggccttgc atttctttaa gactttatat gtcggcatgt tcatggcaaa cgaggtgatg 3371941 tcccacgacg gcttatttat gtaataggaa taaagcagtt ctgcagcgtg ttttgcagcc 3372001 tcgtccaatg tcagcgattt cactgactcc cgctccattt gatcaagata ccctataatg 3372061 atcttttttt tcatctgacg tttttcgaga aggtacagca gaaaatcgtc cttgctgaca 3372121 aaatgaacat aaaatgctcc tttgctgtac ccggcggctc tgctgatatc ttctacagaa 3372181 accggatcat acgctcggtc aatcaacaaa ttcacgccag cgtctataaa actttcaaat 3372241 gttgcttctc ttttaatttg aaatttgttt tttttcatat ttttctcctg gcggtaatga 3372301 ttacccttat cttacaccgg atcaatcttt agcggtattt atttctttaa acggttatgc 3372361 tattcggttt cccaggggtc atttttaata ggctaaatga tttattttca tttacatact 3372421 atccagtcag tatttaattg tttattatta taaataaggt ccattggtta tattagtcat 3372481 ttttttaggg aataggtagg tggtttttcc ttcagtttgt gaacaccgag caactatgtg 3372541 tgaaatttgt tgtactcgcc tccatcatcg cgctggcttg tcttttattg cccgcatgtt 3372601 gcaggaaaac attttataca attggaggtt actatgaaaa ctcatgttaa aaaagatttg 3372661 gacaaaggtt ggcatatgtt aattcaagaa gctagatcca ttggattagg cattcatgat 3372721 gtgaggcagt ttttagaatc tgagacagca tcaagaaaga aaaaccacaa aaaaaccgtc 3372781 cggcaagact agtccgaaca ggcggatcta tttacctctg gcttttctat cacctgatct 3372841 gagttttcac catatcctct attcaaaagc aaatcgctgc gctgagcttg aggacaaacg 3372901 gtgtgtcagc taactacgac agacagccgg tgatgcgatc acctcttggc acatgcattg 3372961 tcataaagag gtgatgcgaa catgataacc gtgctctggt aaacagcagc tttgctgaga 3373021 acaagctgca ttcggtgagg ttttgaaagc aaactcgttt atacacggcc gagcttgaaa 3373081 accttcgcct gtctttagac cactgtgttc acctcttcac gacttccttc ttttttcatc 3373141 ctccagctat tgtacaacgc ataaatcgga ctttcagtac atacctattg gtgtaccttt 3373201 ttgcttacgt ttagcgaata aaaggaggaa agccatgtac aaagctgatt ataaacagat 3373261 tgctgcaacg ccgtcttttc aagctttttt aaagcagaaa cgcgctttta ttgttccttc 3373321 tgcgattttc ttttttgttt tttatttttc actccctgtt ttgacatctt atttcacctt 3373381 tttgaatgca ccggccattg gagctgtttc atgggcttgg ctgttcgcca tcgcccaatt 3373441 cgctatgacc tggatactga gtactgtgta ttcccggaga gccgcccatt tcgataagta 3373501 tgtaagcgct ttaaaagagg atctgaaggg tgaacagaca tgaatatgac tgctttttta 3373561 ttatttttgg cgattgttgg cctgacgctt attatcacgt attttgccgc gaagcggacg 3373621 aaaacgacga gtgagtttta tacggcgggc ggcgggctca ccggcgttca gaatggactg 3373681 gcaattgccg gtgactacat gtctgccgcc tcgtttctcg ggattgccgg aatgattgcg 3373741 ttatatggat ttgatggctt cttttacagc atcggttttc tggtggctta tctcgttgtc 3373801 ttgtacatcg tggcggagcc gcttcggaat cttggaaagt acacgatggc agacatgatt 3373861 gccgctcgct ttaaagaaaa gaaaatccgc ggtgtcgcgg ctctcaatac cattgccatc 3373921 tctacttttt atatgatcgc ccagctcgtg ggggcgggcg cgctgatcaa actgcttcta 3373981 gggctggatt ataccgcggc tgtcctcatc gtcggagtgc tgatgaccat ttatgtcgtg 3374041 tttggcggca tgatcgcgac aagctgggtt caaattatta aagctgtttt gctgatggcc 3374101 ggcacactcg tgatttcgat tatcgtgttt tcgaaattcg gctttagcct taataccatg 3374161 tttgaacaga tgaaaacggc tactccgctt ggcgctgatt ttttgaaccc cggaaataaa 3374221 tacaaggtgc cgcttgagac cttgtcgtta aacttggcac tcgtgctggg aaccgccggg 3374281 cttccgcata tattgatccg gttttatacc gttaaggatg ccaagacggc ccgtacatcc 3374341 gttgtgtcag cgacatggat tatcggtgtg ttttacatta tgacggtatt tctcggcttt 3374401 ggtgccgcgg catttgtcgg ttttgacgcg attacggcgg ctgatcaagc gggaaatatg 3374461 gcggctccgc ttttagcaaa agcgctcgga ggagactttc tgttcgcgtt tgtatcagcc 3374521 atcgcctttg ccaccatttt ggctgtcgtg acagggttgg tgctgtctgc cgcctcagca 3374581 tttgcccatg atatttacag ccagatcatc agaaagggag aagcaactga aaaagaacaa 3374641 atgaaagcgg ccagatgggc ttctgtcgcc gtgtcagtgc tctcgattct ccttgcgatt 3374701 tttgcacaat ccttaaatgt ggcgttcctt gttgcactcg cgtttgcggt agccgccagc 3374761 gcaaaccttc cgctgattgt gtttacagtc ttctggaaac gattcaatgc ctcaggcgct 3374821 ttatggggca gcctgacagg cctgatcagc gcgcttgtgc tggtatcgat gagccctagt 3374881 gtgtgggacc cggccggagg tgctattttt accggtgatc cgctcattcc gctatctaat 3374941 ccaggaatta tttccatccc gctcggcttt ctcggcgcgt ggctcggaac ggtgctgtcg 3375001 tctgataaaa caattgatga agatacgttt gcagaaattc aggtgaaggc gcatactggc 3375061 gtccatatgg aacaggaata aaaaaagctc tctttatcga gagctttttc cttacttttt 3375121 cttctgctcg tcagaaatcg ctttttcaaa tacatccttg ccggcagcac ccggaattac 3375181 agtgtcaccg ataataaagg ttggaacggc tgtgatgtca gcctcttcat aggcgtgctt 3375241 caaggcttgg cgctgcacgt cctgatatgt tcttgtttcc agtgctgatt tgaatgatgc 3375301 accgtctaat cccacttcct cggcgagctt cgtcaagatg tcaatatcgc cgatattttg 3375361 gtcctcctgg aaaaatgcct gaaagacacg ggtgttgtat tcatgtcctt tattgtattc 3375421 cttcgcaaaa tggaagcctt caaacgcgag gtctgtatac ggatggggcg agacgtttgg 3375481 aaaattgatc tcgactccta atttctccgc cattggctga attgatgtct gccacatgta 3375541 ctgtttagaa ggatcattga ccggatcaag ctgaggagat gggcttgggc gcagttcaaa 3375601 cggcatccac tcgacttcaa catcctttcc ttttatcgct tcttcaaaag cggcttttcc 3375661 aacaaaacaa aatgggcaga cgtaatctga ataaacttta atgtgtactg tcatgataat 3375721 ctcctttcat actaaattga ttttaaactg taacaattaa agttacaact gttttttaat 3375781 aaagaagccg atttaggctt ctttcagatt gatgacaaaa tcctaaaaag ttttaggatt 3375841 ttgtcatcct ttcagcgtga ttgaaaaccc ttgaagtcta ggaaagccga gcattggagc 3375901 ggagcgaatg ctctaattcg tgagcaccaa cgcacaggct tgacaacgaa tgcgagggtt 3375961 tgtcgacacg ctgaaagaag cctgtaaagg cttcttttat gattccagca aacgctgggc 3376021 aatatattct ccttttttgc agccgcctgg gcatgcgtat aaagcagaac cgattgtttg 3376081 tgtatattcg tttaacgcat cctttgctga aagagccttc agcatcggga taaactgatt 3376141 gtcgggattt ttttgaaaac tgataaacag gagacctgca tccatatagc cggttttcgg 3376201 atcaagtcct tctgtgtaag agaaagctct tcgcaaaatt tgtttcccag tagatttcgc 3376261 tagactgacg tgtgaattag acggaatttg attcagcttc acgggatctg tttccttttt 3376321 ctgcccaaaa ggcgcccccg agctttttct gcggccgaag gtatcctctt ggtccttgag 3376381 ggaagagcgg tcccatacct caaggaacat tttgattttc cgaaaagcca tataggtgcc 3376441 gcccgtcatc cagtcaggct caccagactg aatccacacg atcgagttca tcaacgtgtc 3376501 atccttcgtg ctctggttgc ctgttccatc tttaaacccg aagaggttgc gcggtgtttc 3376561 accatttttt ccaccgctta aaaagccttt gttcacaaaa cggacctcac aagtgccgac 3376621 cgcttgattt agcaggttac gcagcgcgtg aaacgccact tgctcgtcgt ctgcacacac 3376681 ttgaatgcag atgtccccgc ctccctgctt ttcatccagg ttgtcattgg gcatcgctgg 3376741 aagagcggct aggtgcttcg gttttttgct tttcagtccg aagcggtcct ttccgtcttt 3376801 ttcaaaaaag ccaggcccga atccgaatgt gaccgttaag ttggaagggg ataaatcagc 3376861 agactcacct gtatcctgcg gcggcagata ctgatttctc tgctccgctg acattttctt 3376921 gccagacgtc agcatctgtg tgagacttgt ccagtttcta aataacgtaa tgatgtcgct 3376981 tttgtctttt gctgttacat ccagtgcagc aaaatagaca tacgtctgat gggcagttgt 3377041 gattccggcc tgatgctttc cgtaaaacgg aacaatctgc tcctcctctt tttcatcctt 3377101 tttcgatggc ttagccgcag tctgaacaag cggagcgaga ccgccgagac cgctggcacc 3377161 gatcgcaacg gctgcccccg ccatcgctcc ccattttaaa atgtcccgtc tgtgaatttg 3377221 ttctggcttt ttctgttcat cgctcatgat gttacaaaac tccttttata gcacattcgc 3377281 aatcttcgac atggtttcag aaagagtcgt cagcttagtg ctcagctctc tgatttgctt 3377341 ttcacttaat ttatcataag acgtatagga ctgatcattt gttttgtatt ttgccattaa 3377401 aacttcaaat tcgctgaact ccgtatccag tttttccgtc aagtcggagt gatcttttac 3377461 aagcgcgctt ttcactgttt gataaacggc ttcggagcct tccacatttg ccataaggtc 3377521 aactaaatca attcgtgagt agcgctcttc ttctcccgtg attttcgaaa ttccggcttc 3377581 gttcagaagc tccatcgcgc ctgcaacaat ttgttcaggt gttaatttca gtgattgaat 3377641 tgaaccgtca agctctttta catccttgag aagctggtca gctgttgcct tttccccgga 3377701 aatatcttga tccttccaaa tggccttctc aagcttatgg aagcctgtcc atttgtctcc 3377761 ttcttcaaca tcgttttctc gtgcgtcaat tttcggatca agatctccga ggctttcagc 3377821 gatcggttcg attcgctcgt aataaacacg cgctttcgca tataacgttt tggacttttc 3377881 gatatcgccg gatttcacag cacccgtaaa tgcttcagtc gctttgacaa gctggtcact 3377941 ctgctctttg acatagcctt tatactcatc cgctgctttt gccagctgat cgctagcctt 3378001 tttgccgctc ttcttcgctt ctgtcaggtc ttctaaggat gctttcaatg actcggattc 3378061 tgtcttgatt tttcctgcat ccggtttgtc tttttgcgct tctgtgtaga ttggctgaag 3378121 atgcttttcg atttctgtat attcgaatgg atagtcgctg cgaatatcgt tttcaaagga 3378181 aagccagtag ctgtttaact ctttcccctt cttttcaatc tctttttggt ctcctttttc 3378241 cactgagtca ttcagcttag aaatgatggt ttccatttta tttacggatg cggtgatttc 3378301 tttagtgacc ccgctttttt cagatgaagc tttttctttg gttgaagatg tgtcattggc 3378361 tccgcagcct gcgcacagcg caaggatgca tccggctgat acagcgattt ttgtgaaatt 3378421 cattttgtca gttcctttcc gtttgtaaaa tgttttgccg cttctgaaac aagcgcaatc 3378481 agtaaaaaga gtaaaatcaa catttgcgga atcgtgctgt acacagacgg ataaattcct 3378541 agcaccgata cagacggcag ccagctttct gcatcagacg gaagaatgcc cgccagttga 3378601 aggctgtgaa cgccggttcc gagaaatttc acgcacatat acaggacaac cgccattgat 3378661 agaagaaaaa acggcttcaa tggaatgcgc attccgagct tgatcatcag aacaccgacg 3378721 atgacgagaa cgataagccc tgcggcagtt ccgccgatca gttcagtgag cgggagcttc 3378781 ccgacaagcc cgatgaaaaa gatgaccgtt tcgagacctt ctcttacaac tgccagaaat 3378841 gcaatgagcg caaaggaaag caggcttcgt ttttttagtg cctgtgactt ctggatattg 3378901 attttttctc tccatttatc cattgaggcg tttctgtgca gccacacccc gacatacaaa 3378961 agcatgacag cggacagtac gccggtaacg ccgccaagca agaaattgtt ttctccgaat 3379021 acactggagg agaacagaac cgtgacaccg atgccggctg ctaaggaaac agccatgccg 3379081 gcggacgccc cgccccagat ccatgtcgag gaacgcgtaa cccgcgcttt ttttgtcatg 3379141 gttaatagcg ctccgatgac aaggagggcc tccattcctt cacgaaccgg gatcagcgcc 3379201 gcatcccacc agctgtagct gcttgaagcg atcggctcga gcaattgaat catttcgtca 3379261 atttgctttg ataccttttc aggatggctg ccgatctccg ccttcatcag cgccagattt 3379321 tcctccgatg tcgtataggc ttctttcgat tgggacacga catctccctc aacagcgagc 3379381 caggatgtaa ctaaattgtc gattgcggat gacgcttcat ccaattgttt tttttctatg 3379441 aactgttttg tgtctttcaa gctttgtata taggctgtta aggacgccct tgattgacct 3379501 gaggatgtct ttttcagcac gacagcctgc tgataggttt ctaaatgaga cgcaagctct 3379561 tcaagctgtg ttttgagctt acgtgcgtct tgattgataa aagaaagaga aatcatcgcg 3379621 atattcgcgt ccatttcact gtgagaagaa aggttttctt tcttaataga aggttcttct 3379681 tttttccact tcgccttgaa ggtgtcaaac gtttgttgtg ccgaatccat atccccgtct 3379741 tttacggatt tgatcatttg cttgtttaat tgaattaatg cggcgatcgg atcatcttcc 3379801 gcatgtgccg cagaaccgaa aaccatcaac aagctgaata gaataagtgc cagcccccga 3379861 gccatcatgt tcctcctata attgaaaatg attatcattg tataacataa tcatagccag 3379921 ttcctgtcct ttgtcaatta aaatttgaag gtctgaaaac cttgatggac agcaaaaaag 3379981 ctgtcctttt acagaacagc cctttgaagg aaaatgaacg attatcttcc tgttttatac 3380041 gtttgaattt cctcacgaaa cttgcgtgca gcactctcag gatcctccgc ctgactgatg 3380101 gcgctgatca tactgacgcc atcggccccc gcttggataa caggtgcggc attatctatt 3380161 gtgattccgc cgatgccgac aattggaatg ctgatgcctt ggcggcgcac tgcttcgata 3380221 agagatacac cctgtaccgc tctcgtatct tttttcgttt cagtcggata gatcggccca 3380281 agcccgacat aatccgctcc gtcttcttcg gcttgcttca cctcagacat cgtatgggca 3380341 gaaacgccga gaatcatatc acctatggca gctcttacct ctttcgcatt tgcgtcttcc 3380401 tggccgatgt ggataccatc agctttcaga ttcagagcca attccacatc atcattgaca 3380461 atgaacggaa caccagcttc acggcaagct gcctgcgctt tttcagcaaa tttaatccga 3380521 gcctctcctg tcagcgcatc cccgcctttt tcacggaact ggtacagggt ggcaccgcct 3380581 tttaacgctt tttgtacaac tgtaacagga tcggctttcg tattgtttga ccccataatg 3380641 aagtatacag ataataactc tttcatcatt tcccgagaaa tacgagtcat gagacagtca 3380701 ccctttctat agtcgcccat tcttggacgt cttgttcagt aacagttgaa agcttgttca 3380761 gcaattcaat ctgaaagctt ccagggcctt tgtcagccgt ctgctgtgcg gcaagctgag 3380821 cggcgacccc atacgaagaa atggccgcaa tagcagcaaa caatggattt tcttccacag 3380881 cgcaaaacgc accgacgacg gaagtcagca ggcaaccggc gcctgtcact tttgtcagca 3380941 gcttgtggcc gttatgaagg gtgtatacat gtgacgtgtc ggctatgaca tcaacttcac 3381001 cagttatcgc aatgaccgtg tttagctttt gtgccgcctg ctgagccagc cggatgatgt 3381061 cgcctccacc ttcacccgca tcaacacctt tgatcagcca atcggtcacg ccgacggtat 3381121 gggcaatttc cgccgcattt cctctgattg cagcaaggcg cacctcacga atgatgtcac 3381181 gtgccgattc agtgcggaac ggtgttgctc cggcaccgac aggatcaaga atgacgggaa 3381241 cgccatgttc attagctgat tttcccgcga tgatcatcgc ttcgactgac tccttgctca 3381301 gtgttccgat atttaaaacg agtgcacccg caattttcgc catatcggcg acctcttctt 3381361 ttgcgtacgc cataacgggc gatgcgccga gcgcgagcag gccgtttgct gtgaaattcg 3381421 ttacgacatt gttggttatg ctatgcacca gtgggctatg ccggcggaca gccgtaagac 3381481 attttgctgc tgattgtgca tccatatttg catcatcctt tactatcttt tttcgggtcc 3381541 cataaatacg atttcgtatg ttcgagccaa gctctggcgg caaacgacaa gtacctgtcc 3381601 tttctccaaa taatggcgag gtgccaaggg atgaccggat cgacaagcgg aatgactttc 3381661 actttttccg ggtcaaggcc gcggcagatc cgttccggca aaagcccgat cccaaggttg 3381721 gcggatacca tctcactaat aaaatcccat tgtgatgttt cataaatgat atggggccgg 3381781 aacccagcct tgatacattc cgtcataatt cggttgtgca ggacaaaatc ctctctgaag 3381841 aaaataaaag gctcgtcctt caactcacgc agctgacatt ctttctcatc agccagccgg 3381901 tgggaagggt gaacgacaag cattaaggtt tcttttacga ttgtaaacga atgaaagata 3381961 tcttcgtttg cgggaaggac cacaacgccg atatcaagag agccgtcccc gacaccttct 3382021 tggactttta tagaaccgtc ttcgactagc tgaaaggtga cattcggata gttttcacgg 3382081 aaatcgccga gcactctggg gaaaaacccc gatccgatca tcggcggcag tccaatccgt 3382141 acgtgccctt tcttgacttc cataatatca tttaattctg acgtcaggtt ttgaaatgat 3382201 ttaatgattt cctgcgcctg cacatacatg ctatgaccgg catcagtcag ttccacctgc 3382261 ctgccgtttc ggtaaaacag ttcaattccg agctcttctt ctaaattttt gatcattttt 3382321 gatatcgtcg gctgagaaac ataaagggat tgggaagcct tcgtaaaact ttttaaacgg 3382381 gcgacttcca agaaatatgt taaatggcgg atatccatgc gcttcaccct ttctatagac 3382441 aaaaggaata cttcttattc ttaatatata ttttacctat agagagacct tatgtacaat 3382501 aagtatataa gggaggcatc aatatgaaaa aactgttgct aaccgttatt caaatcgctc 3382561 tgttatttat atttgctcgg ctgattaatt gggtgacagc ccttcttcat ataaatattc 3382621 ccggcagtat aatagggatt gtgattcttt tcacattatt gcactttaac attatcaagc 3382681 ttgaatggat cgagcttggt gcagcgtggc ttctcgggga gctgctttta ttttttatcc 3382741 cgtctgccgt cggagtgatt gaatacggag acattatgtc gaaatttggt gtcagcattc 3382801 tgcttgttgt catcatcagc acgtttgtcg tgatggtgtc tacaggaacg cttacacaac 3382861 tcatcgcaaa gagaaaggag aaaaagcata cgtgttcatc ggaattgtaa gtttgttttt 3382921 aacggttttg gtgtatttag gagcaaaaaa ggtatatcaa cgctttccgc gtgtttatac 3382981 gtcgccgcta ttggtgacgc ccgctgtatt agtcggtctg ctgctgctgg tgaatgtccc 3383041 gtacgagtcc tataatctcg gcggcggatt gctgaccgat atgctacagc cggccaccgt 3383101 ggcattcgcg atcccgttat ataaatattt ccctgtttta aagaaatacg cagtggaaat 3383161 tattttgaat gtggccgtcg gttcatgcat cgcgattatt tctaccgctc ttattgcgaa 3383221 atggcttcac ctcggcaccg gcttaattga cagcctcgtc ccaagatcag tgacaacgcc 3383281 gatcgcgatg aacgtatctg aaatgatcgg cggtatgcct gccgtcacag ccgtgtttgt 3383341 gattttaacc gctttgctcg gcacagtgat cggcccgatg gtcatccgtt atttccgcat 3383401 tgataacgaa attgcgcggg gcgtgctgct tggcacaagc gcgcacggag cgggaacgtc 3383461 aaaggcattt gagctcagct ctgtgtccgg cacgatttcc agcgtgtcga tgatcttagc 3383521 tgcgattatg acgctttgcg cggcgccgtt tttgctttca tttatgtaaa aaactgtcct 3383581 ctcgagggca gtttttttta tgtgcttccc cttattgaaa agctggcgaa ttccaatata 3383641 atgtatttgt ggataccaaa ggaggcaccc tgatgcacaa cttgcaggtg aggcggcatt 3383701 atgccgcgtt aaaaggattt tatttgtttg cttttctcgg tacgggcagc ataattccct 3383761 tactcagtat gtatttaacg aaggaacagc atttaagcgg atcacaggtc ggcttgatca 3383821 tgtcactggg cccgattgtg atgattttct ttcagccgtt ttggggcatg ctgagcgact 3383881 atacgcaaaa aacgaaaggc ctgctggcgg tttgcacatc aatcacaggc atcattggat 3383941 tagcctatat tgcatttgac agtttccctc tgtttatttt gattgcggcc tgttttgcag 3384001 cctttcaaag cacgattatt ccactttcgg acagcatttc actaaggtac acacaagaaa 3384061 caaacggcaa ctacggcgga atccgcctgt ttggttctct cggcttcggt gtcgcggtgt 3384121 ttgccatggg acaggtgacg aaccagctgt accccattca cgtgatcttt atctttggct 3384181 gtgcctttct gtgcattgct gccatattgg cttcacaagt gcccggccag cagaaaacaa 3384241 caaaggtcaa tatccgcaaa ggattccggg agcttatcag caacaaaact ttcctcatct 3384301 ttatgatcat cacctttacg acatttgctc caaacttagc gaacaatacg tatttcagtc 3384361 tttttctgga caaaagcggc gcgtcacttt ccgctatcgg cattttattt ttcatcggtg 3384421 tcatttcaga aattccattt atgagattcg cccaaacatt tatagataaa atggggctgc 3384481 tcaacgtcat tatgctgtca ggcggagtct cattattcag gtgggcgctc tatttcacgg 3384541 cgccttcact atggatcatt tatgcgacgg tctttcttca gggagtggcc atcggtttat 3384601 ttatcccggc ggcgcttcaa tatgtgaaaa agattacccc aagacacgtt gaagcgacgg 3384661 cgctgaccat gtacgccgcc attggcaacg ggttcggcaa ctggttctgc acatttgcag 3384721 gcgggtacat ttttgactac gtgtcgatct tcgcagtcta cttgcttttt ggcattctga 3384781 gcatagcagg ctttggcctg acattatatt taatgaaggc tgaaaaaaac aaacatacac 3384841 ttcatcagcc ggctgttact tttaaaccat aatgactata atgaacaaaa gaaaggatgt 3384901 gcgttatgaa cgggcaagag cgaaacagca tttcgaaagg gttgcaggtt gatattgtat 3384961 tgaaagcaga tcaaaaaaca ggaaaactga cgagagggac agtgaaggat attttgacga 3385021 aatcaaactt tcatccgcat ggcattaaag tccgtcttga agatggccgc atcggccgcg 3385081 accagcagat cgtttctaca taaaaaaaag ctgcccctga acagggcagc tttttcatta 3385141 ttttttctgc agaaggacca ctttcaggta gttgccttcc ggaaatgccg aaatcgtttt 3385201 gaaatcctcc ggcagcgtaa attcctcaat gatcgtgtag cgttcatttg tttctttaaa 3385261 ggcggcatca ataaagcctt tgaacttctt catgccaaag gcgctgctgt ttgtagaggc 3385321 aacaatgaca cccttgtcag cagtgatggc gatcgtttcc ttcagcaggt ttttataatc 3385381 cttggccgcg ctgaaggtgc gtttttttgt gcgcgcaaag gaaggcggat ctagaataat 3385441 cagatcaaag cgcaaatcct tttttgcagc atatgaaaaa tagttaaaaa cgtccatcac 3385501 tttaatgtcg tgcgcttcgt aatccagctt gttcacgctg aattgctcga tcgttttggc 3385561 aagacttcga tttgccacgt cgacgcttgt tgttttctcc gctccgccaa gcgccgccgc 3385621 cacggagaat gcacccgtat aagaaaacgt atttaaaacg gttttccctt ttgcatagcg 3385681 gtctctgatc gccttgcgca catgtctctg atccaaaaag atgcccgtca tggcgccttc 3385741 attcagatcc accgcgtatt gaatgccatt ctcttggatg atgatcggga actcgcccct 3385801 tctccctttc acgaagtcat catcttcaac gtattgtcca gccgtgtcga agcgtttctt 3385861 ctcgtaaatc gctttataat caagatccat ctcatccaat gcggaaatca gcatgtcttt 3385921 aaaggtgtaa attcccttgc tgtaccattg aatcagcagg tagccgtcat aatagtcgat 3385981 ggtgacgccg ccgacaccgt caccctcacc gttgaacagg cggaaagctg ttgtatcttg 3386041 agcctcaaat agtttggcgc gcgcttgggc cgcttttgtt aatttgctga gaaaaaatgc 3386101 ttggtcaatc tgttcatgtt tattgcgggt aagcgtccag ccaacccctt tgttttgcag 3386161 gccgtaatag ccccgcgcga gaaactcgcc gccgctctca gacacgatat caacgaggtc 3386221 tccttctttc atgtgccccg cactccctgc gagagcttct ttttcaataa ggggatagcc 3386281 tttttttatt ttggcagcgt gtgctttttt tagggtgagt agcttcatat atgtcgtcct 3386341 ctttccgttt gctttctctt atggtaccac aaaacgccaa gatgtctgca ttgacagaaa 3386401 ggaaaggttt ttctacgata gacaaaaaga gttacgagga ggagcagcat ggcaaaacga 3386461 attgaccata caggcatcat ggtaagagat attaacgcgt ccatcacatt ttatgaagag 3386521 gtactaggca tgaaattgaa ggatcgcatc actcacacga acggtgtaat cgagcttgct 3386581 tttcttggct ttgaagacgg cccggaaaca gaaattgaac tgattcaagg ctacagcagc 3386641 gagcttcccg ctgaaggaaa agtgcaccac attgccctgc tgacggatga catcgcggct 3386701 gaatatacaa aagcggaaaa aatgaacgca aaatttatcg acgaggagat cacaacactt 3386761 ccaaacggat accgttattt ctatatcgaa ggccctgacg gtgagtggat tgagttcttt 3386821 cagcggtaaa aataaagaac gtacattttg tgatgtacgt tcttttttat ctataccaac 3386881 tgatatacgt tgactcatcg caaatcatag cttcccagcc catacgctca accaattcat 3386941 ggatgttttt atctttggct aaaaagacat taatgaatga gtcatataca ctcataaaca 3387001 caaaatccat tttctcatca gttaaaacga gctctgttgc ggcttcatca agaaccgtcc 3387061 gcaagttggc ttcagttatg tccaaaacgc cgcggttttc cacaatcggt tctgcgtaat 3387121 aaaaccgatt ggatccgttc gcacctaata cctttaccaa actcggaata tgaaaatttg 3387181 aaatatgatc ctcactggga taatagaggt ctccatttat gttttcatgt aacacctcag 3387241 ccaaatcctc tctcgcgaac tcgtccctta aagcgcctat cgacgtcatt aaagccagcg 3387301 ccagctcagc atgtgtttga aagccgcaag aagacataac cttcttccag gaaacagcct 3387361 tgcctattcc tcttatttca ttatcgtttg gataaatatg ttcataatca ttttttcttt 3387421 ttgcattctc ccatccttca ggcatttgga taaaaggaga aaagataaga gcagcagatg 3387481 agtattcaac tggtacttgt tgtaagattg gtgattcgtc atctaaccat atataatcta 3387541 gcatgcgcac ctcctttaca tattctaaca ttcctttcgt ttgaaagaga tgatcagccc 3387601 tatgacaggc tgatcatcta tcacatcaca tttttatccc cagattcaac cgcactctct 3387661 tcccgccatt tttgatgatc ccatattctg aaaaacggat agtagatagc acaggtgatc 3387721 agcagattta ccagctgcat aactgcgccc gacacctttc cgcctgtcgc caggtaacct 3387781 gatatgagcg gcggcatcgt ccatggcacc gcgattccgg ccggtcttgc caccagcccg 3387841 gtgctcatgc cgatataagt cgcggtaatc gtgaggagcg gtgcgatgat aaatgggaca 3387901 ataaggaggg gattcatgac aatcggcatg ccgaaaatga tcggctcgtt gatattaaat 3387961 agcgcagggc cgattcctaa tcgtccaagc tgcttcattt gtttgctgcg ggagcgcaca 3388021 agcatcgtca ggacaagcgc cagcgtcgcc ccgcttccgc cgacattgat ccaaatttga 3388081 aaaaactgag tcgtaaaaat actcggcagc gcctcgcctg cttggaaggc gagacggttg 3388141 gcatccatcg cgccgtacca aatcggcgcc atgattccgc caatgatgga agccccgtga 3388201 atcccgcacg accaaagcag catctgcaca aattcagcga tcaggcttcc gccgagactg 3388261 ccgccaagga tggaaagcgg tgtgccaagc aggtctccta cgacattgtg cagactctga 3388321 aaaggtgtca tttcaatcag aagacgcgcc agccatacga gaagcacaat gataaagccg 3388381 ggaatcagcg cgacaaatga tttgcttacc gcaggcggca caccgtctgg cattttgaag 3388441 acgatatttt tttgaataat gtaccgatag atttcggttg aaaacaaggc gatcagcatg 3388501 gcgacaaata agcccttgct gccgagcagc gtgatcggga ttccgccccc taccatgatg 3388561 gactccgttg agccatgcgg tgtaaacggc acctcaaacg gtgttgccag cagaaatgcg 3388621 gcaattgaaa tcgctccggc agaaagggca tcgacaccat agctttctgc cagccgatag 3388681 gcgatcccaa aagcggcaat catcgccata atatcaaacg aagcgttaac aggatatccg 3388741 agcttatcgg cccactcgtt cccaaacaca ctcgccatga aatcagcata ccccggaatc 3388801 ggcaagctcg ttaaaatcaa gaagacagac ccgataataa tcagcggcat ggtcaggata 3388861 attccgtcac gcaaagcgct gagatgccgc tgcccggcaa ttttcccggc gacaggcatt 3388921 attttttcct ccatcacccg agtgaatgtg ctcatcttaa aaaccccctt ttctcattgc 3388981 tttgtgaaca acctccgcaa tgttttcttt atcttatttt gaaaacgctt acaaattcat 3389041 ttggaaaatt tcctcttcat gcggaaaaaa tctgcatttt gctaaacaac cctgcccatg 3389101 aaaaattttt tccttcttac tattaatctc tctttttttc tccgatatat atatcaaaca 3389161 tcatagaaaa aggagatgaa tcatgaaaaa catgtcttgc aaacttgttg tatcagtcac 3389221 tctgtttttc agttttctca ccataggccc tctcgctcat gcgcaaaaca gcagcgagaa 3389281 agaggttatt gtggtttata aaaacaaggc cggaaaggaa accatcctgg acagtgatgc 3389341 tgatgttgaa cagcagtata agcatcttcc cgcggtagcg gtcacagcag accaggagac 3389401 agtaaaagaa ttaaagcagg atcctgatat tttgtatgta gaaaacaacg tatcatttac 3389461 cgcagcagac agcacggatt tcaaagtgct gtcagacggc actgacacct ctgacaactt 3389521 tgagcaatgg aaccttgagc ccattcaggt gaaacaggct tggaaggcag gactgacagg 3389581 aaaaaatatc aaaattgccg tcattgacag cgggatctcc ccccacgatg acctgtcgat 3389641 tgccggcggg tattcagctg tcagttatac ctcttcttac aaagatgata acggccacgg 3389701 aacacatgtc gcagggatta tcggagccaa gcataacggc tacggaattg acggcatcgc 3389761 accggaagca caaatatacg cggttaaagc gcttgatcag aacggctcgg gggatcttca 3389821 aagtcttctc caaggaattg actggtcgat cgcaaacagg atggacatcg tcaatatgag 3389881 ccttggcacg acgtcagaca gcaaaatcct tcatgacgcc gtgaacaaag catatgaaca 3389941 aggtgttctg cttgttgccg caagcggtaa cgacggaaac ggcaagccag tgaattatcc 3390001 ggcggcatac agcagtgtcg ttgcggtttc agcaacaaac gaaaagaatc agcttgcctc 3390061 cttttcaaca actggagatg aagttgaatt ttcagcaccg gggacaaaca tcacaagcac 3390121 ttacttaaac cagtattatg caacgggaag cggaacatcc caagcgacac cgcacgccgc 3390181 tgccatgttt gccttgttaa aacagcgtga tcctgccgag acaaacgtcc agcttcgcga 3390241 ggaaatgcgg aaaaacatcg ttgatcttgg taccgcaggc cgcgatcagc aatttggcta 3390301 cggcttaatc cagtataaag cacaggcaac agattcagcg tacgcggcag cagagcaagc 3390361 ggtgaaaaaa gcggaacaaa caaaagcaca aatcgatatc aacaaagcgc gagaactcat 3390421 cagccagctg ccgaactccg acgccaaaac tgccctgcac aaaagactgg ataaagtaca 3390481 gtcatacaga aatgtaaaag atgcgaaaga caaagtcgca aaggcagaaa aatataaaac 3390541 acagcaaacc gttgacacag cacaaactgc catcaacaag ctgccaaacg gaacagacaa 3390601 aaagaacctt caaaaacgct tagaccaagt aaaacgatac atcgcgtcaa agcaagcgaa 3390661 agacaaagtt gcgaaagcgg aaaaaagcaa aaagaaaaca gatgtggaca gcgcacaatc 3390721 agcaattggc aagctgcctg caagttcaga aaaaacgtcc ctgcagaaac gccttaacaa 3390781 agtgaagagc accaatttga agacggcaca gcaatccgta tctgcggctg aaaagaaatc 3390841 aactgatgca aatgcggcaa aagcacaatc agccgtcaat cagcttcaag caggcaagga 3390901 caaaacggca ttgcaaaaac ggttagacaa agtgaagaaa aaggtggcgg cggctgaagc 3390961 aaaaaaagtg gaaactgcaa aggcaaaagt gaagaaagcg gaaaaagaca aaacaaagaa 3391021 atcaaagaca tccgctcagt ctgcagtgaa tcaattaaaa gcatccaatg aaaaaacaaa 3391081 gctgcaaaaa cggctgaacg ccgtcaaacc gaaaaagtaa ccaaaaacct ttaagatttg 3391141 cattccaagt cttaaaggtt tttttcattc taagaacacc acacacaacc tttttcccat 3391201 ccattgtaca ggcttttcat actattgcta tacagccatg aacagcataa aatgaacgtt 3391261 attacagtta tcaccacata tggcgggatt gtgactgggc aggcaggcaa gacccaatga 3391321 tgcaaaggga gtattaatgc ctaaaaaaca gggcatttta actcttcttt tcgtgttggg 3391381 ctcataacgg cgccttggac aaccccctat tctcatgctc cgtcgtcgac gcgggcattt 3391441 ttgtcatttt cagccggtat ttctcacttt tttcattttg attgtcaact tttcatttga 3391501 tacgatgaac aagccgactt ttcttcagca aaggaggttt taattgcttg cataaagaga 3391561 ttgcaaaaga attactgctg ctcgcaggag gaaaaaacaa tattatcagc atcagccatt 3391621 gtacgacccg tcttcgtttt gatgtaaagg acgagacgaa aattgatata catgccattg 3391681 agaacctgca aggtgtgcag ggcacctttt tccgctatgg gcttttccag attatcttcg 3391741 gagcaggcgt cgtcaacaaa atatataaag aagtcgttca tgtatgggag accgcgcctt 3391801 ctgaagagcc tgtccaccag aaaaaagcca gccggaagct gaaccctgcc gcagcttttg 3391861 cgaaaacact gtccgatatt tttgtgccga ttattccggc aataacagca agcggcctgc 3391921 tcatggggct gatcggcatg attaaggtgt ttcattggtt cgctgccggc agcccatgga 3391981 ttaaaatgct cgacctcgtg tccagcacag cctttatttt actgccgatt ttagtcggct 3392041 tcagtgctgc acggcaattt ggcagcaacc catacctagg ggcagtgatt gcagggcttt 3392101 tgacgcatcc tgatctgctg gacccgtcta tgctcggcag caaaaccccg tcttctttag 3392161 acatatgggg gcttcatatc ccaatgatgg gctatcaggg ttccatgata ccgattcttc 3392221 tttccgtttt tgtcatgagc aaaattgaga agctattaaa atcgattgtg ccgaagtcgc 3392281 ttgatgtcgt gatcattccc tttattacgg tcatggtgac agggtgcctc gcgctgattg 3392341 tgatgaatcc cgccgcgtcc atcatcggcc agatcatgac acaatcgatc gtctatattt 3392401 atgatcacgc cggcattgct gccggagctc ttttcggcgg catctactcc accatcgtcc 3392461 tatctggatt gcatcatagc ttttatgcaa ttgaggcaac gctgcttgct aatccgcatg 3392521 tcggtgtcaa ctttttagtg ccgatatggt cgatggcgaa tgtggcccaa ggcggagcgg 3392581 ggcttgcggt attcctcaaa acgaaacaat caagcctgaa gaaaattgcg ctccccgctt 3392641 ctctgaccgc gtttttaggc attgttgagc cgattgtatt cggggtaaat ctcaaattga 3392701 tccgtccctt tatcggagca gccatcggcg gtgctattgg cggagcatac gtggttgcgg 3392761 tacaagttgt ggcaaattcc tacggactga caggcattcc gatgatttca atcgtgctgc 3392821 cgtttggcgc cgctaatttt gttcattata tgatcggttt cttgatcgca gccgtctctg 3392881 cttttatagc tacattgttt ctcgggttta aagaagagac agaataactg gatttattcg 3392941 atttcattca taaaacgggg gatgaaagga caaaaaagct atgaaaatta aaagaatctt 3393001 aaatcataat gctatcgtcg taaaggatca aaatgaagag aagattctct tgggtgcagg 3393061 aattgcgttt aacaaaaaga agaatgatat tgtcgatccg tcaaaaatag aaaaaacctt 3393121 tatcagaaaa gatacacctg actataagca gttcgaagag attttagaaa cattgcctga 3393181 agaccacatt cagatttctg agcaaattat ctctcatgcc gaaaaagagc tgaacatcaa 3393241 aatcaacgag cgcattcatg tcgctttttc agaccatctt tcttttgcaa ttgaacgcct 3393301 gagcaatggg atggttatca aaaatccgct gctgaatgaa atcaaagtcc tttatccaaa 3393361 ggagttccag atcggcttat gggccagagc actgattaaa gataaactgg ggattcacat 3393421 tcctgatgat gaaatcggca atatcgccat gcatatccac acagcaagaa acaatgccgg 3393481 cgatatgaca caaacgcttg atattacaac aatgatccgt gatattatcg agattatcga 3393541 aattcaactg tctattaata tcgttgaaga taccatctct tatgaaaggc tcgtgaccca 3393601 tctccgcttt gccattcagc atatcaaagc aggcgaatcc atttacgagc tggacgcaga 3393661 aatgattgac atcattaaag agaagtttaa ggatgccttc ctgtgtgccc taagcatcgg 3393721 cacctttgtg aagaaggaat acggctttga gtttcctgaa aaagaattgt gctacatcgc 3393781 catgcatatt cagcggttct accaacggtc agtcgcacgc tgagacaaac aaaaaacgct 3393841 tttgatcatc tcaaaagcgt ttttttatct gatttattgg ttgatcgccg gattcccaat 3393901 cgtattccac ttcgtatagg acatgtaatg gaaatactca tcgcgatacg gatgttttgt 3393961 attggagttc caaggctttt ctccgccgca gaagtgcacg attgccgggt tttctcttgt 3394021 ttcattatat tgcttccgcc ctaacagagt cgatggggtt ttcagcttta acatgatata 3394081 ggtttgagcg ttccagcgcg gatgaagttc ataccactga tcatacaaga tcgcattcag 3394141 tgcatcttgg tcatgcagca caagaaagtc ttcgtctggg tgttcattga taaagttgat 3394201 gactttttct gtgatgtttt gctttctcca agactcaaaa tcaataatca tgatacctga 3394261 gttaaaatac ttccctgtat cagtgacgtt catttctttc aggcgttcat gctgccccgc 3394321 atcctcaaca gcggctacgg tgtatggcgc aatgtctaag tcccatagct tagaaatatc 3394381 ctctaggaca agcgcatcac aatcgatgta aatcattcgt ttgatgcttt catccttaat 3394441 taagtcggga atcgaaatgc ggtaatacgc ggcttttgta atatggctgc tctcaaccgc 3394501 atgttcatac atgttggtat ccacttctaa aaactcaatc ggcactccga atttcaaagt 3394561 ggtttcttcc agtctttttt tgttatcagg cttaattccg ccatcaatga cgtataattt 3394621 tacctctctc tcctgatcca tgttagtcaa taaagaaacg aacatcccac ctaaatgacg 3394681 agcataatta tcatctgcgc atgatacgat atgcatgatt tcatctttcc tcaatggtat 3394741 tcatctccct ttttgttgta caagttacat accctttttc aaaaaaataa acacgttctc 3394801 cgacattttt ttaaacagaa tgtgtgatac aacaaaaaag gtgtcatttt ttgaagatgc 3394861 gataaagcca ataaagaatg aaaaagcttg cgattgtgat ggcttcagcc gagacgatat 3394921 accacggcca tggcccgaga acatctaaga gagaggaacc gcccggtttt ttcgtcaaat 3394981 acatataatt cgcgccaagc cagcgatcaa tcagaaaaat acagacgccg tacacattaa 3395041 caagcaggac tgtcacccat aacgagcgct ggcccattct gtaggtgcca atcacagcca 3395101 tcagcagaca ggataaaaac acagacccgt gagaaataaa aaagaggata tatcggatat 3395161 gcggaaatga aaacataccg aggtcaggag tggcaagagc ctgaatcgaa ctgccgatgc 3395221 cgacaaaaaa caaaaacaca aacagctttc tgctttttgt cactaacata atagctgaca 3395281 aatacaccga caggtcacta agctggagag gcaatgaagt gcgcaccgac cacctgtccg 3395341 tggcgaccat ccatatttga tagccgattt gcgaaccaag caaaagaaac acaaacagag 3395401 aacgcaaaaa ccggctggcc ctcggctgct tgacctcatc ttggaacaaa aacaacagaa 3395461 tggccaaaag ggagataatc gctaacgtca ctacatgctc tgtcgaaaac agatgaaacg 3395521 gatcatgctt atagtcggat tgaacatatt tttgcaaaac tgcacccccg ttttcgggtt 3395581 tttgtttatt ttggcgttgt ttgggctttt tttattcaac cgatatatgg gcttgaagtt 3395641 cacaccagac tctgttaaaa ttcgtttcat agctaatgat tctgataatt taaggcaggc 3395701 ctaaaaaatg gaacgttcac atcaacatca gcagcttcgg aaggaagaac acgatacact 3395761 ttctaagctc aaacaaatgc ccgtcgagtc actcaacctg gaagccattt cgatcgctac 3395821 gaatctgtat cggtctgcac aaaggctccg tgtcaaaatg gagactgagg ttctttctac 3395881 ctataacctt tcttggaccg ctttctccat tctttatgat ctatgggtat ggggagcgct 3395941 cgaaacgaga aaaatcgctg agctgtcagg gatatctaca gctacagcaa gcaacgtgat 3396001 caaaacgctc gaaaaaaaga gtttttgccg taaaagcatc gacacaagag atcggcgact 3396061 cgtgtttgtc tcaatcaccg attccggcaa acaagcgatc gaagaactct acccggagtt 3396121 tcacaaaggg gaaacagagc tcattgcggg aatgacgaag gacgaacaga aaatattgac 3396181 agggctgctt agaaaggtag ctgacaatct tcatacaaca taagctttga cgggaatcca 3396241 gtagcggttt gtctccctgt ttcagagagc cggcggtagg tgcgagccgg cgcacaggca 3396301 aacgtgaatt acctccccaa gctttctttg tgaaccttag tagcaaagaa cgggaaaccg 3396361 ttattcgaat gagcggaaga caatgtcttc aaccagggtg gtaccgcgtg cattgagcca 3396421 cgtcccttat tgggatgggc tcttttttgt gtttgtaaaa aaggaggaaa aatgatgaga 3396481 acatttgagc agctcacagc gtcacaacaa aaagaggtag aaagacagct tcagctatac 3396541 atgacaggcg cccacgaagt cataccgccg gaggaattaa aggcaaagct cgtgaaatca 3396601 atttccacgg gcacgccgct taaaattaag ctcggattag atccgtctgc accggatgta 3396661 catttgggcc atacggttgt gttaaataag cttcgccaat ttcaagaaaa cggccacatt 3396721 gtccagctgt taattgggga tttcacagga aaaattggtg atccgaccgg aaaatcggca 3396781 gccagaaagc aactgactga tgaagaagtt cagcacaatg ccaaaaccta ctttgagcaa 3396841 ttcggaaaag tgcttgatcc agaaaaagtc gagcttcact ataactcaaa atggctgaaa 3396901 acattgaatc tagaagatgt cattgaatta gcagggaaaa taacggtagc ccgcctgatg 3396961 gagcgcgacg actttgaaga acgcatcgcc atgcaaaaac caatctcact gcatgaattc 3397021 ttttacccat tgatgcaggg ctatgattct gtcgttctcg aaagtgatat tgaattaggc 3397081 ggaacggatc agcatttcaa tgtcctcatg ggacggcatt tccaagaacg atacaacaaa 3397141 gaaaaacaag tcgtcatcct tatgccgctc ttggaaggct tggatggcgt cgagaaaatg 3397201 tcgaagtcga aacacaacta cattggcatt aacgaacatc caaacgacat gtacggaaaa 3397261 acgatgtcac tgcccgacag cctgatgaaa aagtacatcc acttggcgac agacttagag 3397321 cttgaagaga aaaaacagct cgtaaaagac ttagaaaccg gcgccgttca tccgcgtgat 3397381 gccaaaatgc ttttagccag aacaatcgtc cgaatgtatc acggagagaa agcagcagaa 3397441 gctgccgaac actcgtttaa aacagtcttt caggaaaaca gcctgccgga agatataccg 3397501 gccgtaaact ggaaaggcga aaaaacgata gcgatgattg atctgctcgt caagctaaag 3397561 ctcctctctt cgaagagcga ggcgcgccgc atgattcaaa acggaggtgt acgcatcgac 3397621 ggagagaaag taacagatgt tcacgccaaa gcagagataa gagagaatat gatcatccaa 3397681 gtcggcaaac gcaagttttt aaagctccaa taatctgata ttccgaaacg cttatgaccc 3397741 ttcattcata agcgtttttt tgcaggtata aagcactgtc ttttcaaaaa cgctctccat 3397801 cttgcaggaa actcctttag catcccgaaa tattccccaa ccatacattt aggggaggtt 3397861 tatttttgat gaaaaagctt ttgactgtca tgacgatggc tgttttaact gccggcacac 3397921 tgctcttgcc ggcacagagt gtcacccctg ccgcgcacgc tgtacaaata tcaaatagcg 3397981 agcgcgagct tccattcaaa gcaaaacatg cgtactctac catttctcag ctaagtgaag 3398041 caatcggccc cagaatagcc ggaactgcag ctgaaaaaaa gagtgcccta ttgatcgcct 3398101 catcaatgag aaaattaaag cttgatgtga aggttcaacg attcaacatt cctgaccggc 3398161 ttgagggtac actgtcttca gcaggacgcg atattcttct ccaagcggcg tcgggctcag 3398221 ctccgactga ggaacaaggg ctgacggccc cgctttacaa tgcgggattg ggctatcaaa 3398281 aggactttac cgctgacgcc aagggcaaaa tcgccttgat ttccagagga gacctgactt 3398341 attacgagaa agccaaaaat gccgaagccg ccggagcgaa agctgtcatc atttataaca 3398401 acaaagaaag cctcgtgcct atgacgccaa acctgtcggg aaataaagtc ggcattccgg 3398461 tcgtcggcat taagaaagaa gacggcgaag cacttaccca gcaaaaagaa gccaccttaa 3398521 aactaaaagc attcacaaac caaacctccc agaatatcat cggaatcaaa aaaccaaaga 3398581 acatcaaaca tccagacatt gtgtacgtga ccgcccatta cgacagtgtt cctttttcgc 3398641 ccggagcaaa tgacaacggc tcaggtacct ctgttatgct ggagatggcg cgtgtcttaa 3398701 aaagcgttcc atctgataaa gaaatccgct ttatcgcttt cggcgccgaa gagctcggcc 3398761 tgctcggctc ctctcactat gtagatcatc tatcggaaaa agagctgaaa cgaagcgaag 3398821 tgaacttcaa cttagatatg gtaggcacaa gctgggaaaa agcgtctgag ctgtatgtca 3398881 acacattgga tggccaatct aactatgttt gggaatccag ccgtacggct gctgaaaaaa 3398941 ttgggtttga cagcctgtct ctgacacagg gaggatcatc tgatcatgtg ccattccacg 3399001 aagccggcat tgattccgct aactttattt ggggagaccc ggaaacagaa gaagttgagc 3399061 cgtggtatca tacccctgaa gactcgatcg aacatatcag caaagaacgc ctccagcaag 3399121 caggcgatct tgtgacagcc gctgtctatg aggctgtgaa aaaagagaag aaaccgaaaa 3399181 ccattaagaa acaaatgaag gcgaaagcat ctgacatttt tgaagatatc aaataaaaaa 3399241 agacggcact tgggtgccgt cttttttaat ccacttcttt cttaatcccc agcattttct 3399301 catctaggta atgggcaatc tccgcggctt ctttcagctc atctgttaat tgcttaggaa 3399361 cgtcattgtt caatttataa taaattttat gttcaaggct cgcccagaaa tccatcgcga 3399421 ttgtccggat ttgaatttct gctttgacgt attccacacg gttcgttaaa ttcacaggca 3399481 tctcaatgat taaatgcagg cttcgatagc cattcggttt gggtgtctgg atataatcct 3399541 ttacctttac gattctcaaa tcttcatgct gcttcaacac attcacgaca ttataaatgt 3399601 cagaaataaa ggaacagatg atgcgcacgc cggcaatgtc gtgaatatgc tccttcattt 3399661 ccttcgtcgt aatctcacag ccctttctca ttaacttatt cacgatgctt tcaaagcttt 3399721 ttacacggga ttttgtatgt tcaatcgggt tgtgtccgtg aatgaggtta tattcctggc 3399781 tgataattga gaactttgta tcgagcgcat ctagcgcaaa tttataaact aataactcat 3399841 ttttccaatc ttccattact gtttttaaat cgtccatatg tgttacagat aaatccatgt 3399901 tcgtcatctc ctttaacgga actttatccg ctgtccatgt actagacgtc cctgtctgct 3399961 gcaaggttct atgaattttt ttacaaaatg cggtcgattg taacaaaaaa agaccgcatg 3400021 aaacgagcgg tcttttttat tatcggaaat agctgatcaa taatccgatc gagagcagga 3400081 atccgaaaaa tgtatttgtt tgggctgttg atttcattgc gacaatcata ttcatcggca 3400141 tttcgttctg gacgaagccc ttcactgcct gaaccggctt aggcacgctc aaaaagacga 3400201 caaacagcca tgggcttgcg gcaccggtaa taaccaagcc gacaacccag atataagcga 3400261 cggcaaacga cgcagctaac agagtaacag ctcccttatg ccccatcaaa atcgccaatg 3400321 ttttgcgtcc gccttttttg tcctcttcaa tatcacgaat gttgttcgac aggttaatcg 3400381 cgccgacaag aatcgcaatc gggatggaaa tcaaaatgct ctgcatattg atcttatctg 3400441 tctgaatgaa aaacgaaatc agcacaaaca ccgaacccat gcaaatgcct gagaataatt 3400501 caccgaacgg cgtgtacgca atcggcagcg gcccgcctgt atacaggtag ccgatcgcca 3400561 tgccgacaag gccgatcagc gcaagccacc agctgctgct ggcacaaata tagacaccga 3400621 gcaaaatggc aatcccgtat gaggcaagag ctaattgcaa aatcgtttta ggcttcattc 3400681 cgtggcgtac aatggcccct ccgattccga ctgattctgc tgtatctaat ccgcgtttaa 3400741 aatcatagta ttcattaaat aagttcgtcg cgatctggat ccataggcaa gaaaacagca 3400801 tagccaaaaa cagcagcaga tcaaccttca cataaaacat cgccaaaacg gttccgagca 3400861 gcacaggcac aaacgatgcg gttaacgtat gaggacgggt taactgccaa aggatctgcc 3400921 ccatgctttc tttttgcggc gctgtctgac cctcaccctt atttgtttgg ttcatcttcc 3400981 tcttcctttc tattaaaagg cttacttttt ttcagccggc agcttaataa aaaactcctt 3401041 ttgcttcctt atctatcata atgacttctc ccttatttca caagataccg caagaaggcg 3401101 ttttctttct tattatacgc ttctcgccct gatttcatta ggtttctgct ttcacttgaa 3401161 cgaacaggta cagaaaaatt tttttaagta cattacactt tttaaaagtt aaaaagatct 3401221 tttgactcca ggtatctttt cctttattat gaatcagctc gaaacattcc attcttgccc 3401281 ttgcaggtat aaagattcat tttcaaaaac atacgccgat atattaattt gagggagatt 3401341 agggaaaaaa tgaaactttt tgagcatctg atcgtcaaat aatcatgtga ttgtcgaaaa 3401401 aacgggaagg gaatttttga tatgctgcaa ttaatgaaac agctgtatga aaaacccgct 3401461 gtcaagtgga catgtcatac aggcttttat ttgatgatac tgcttgtttt gttttttatg 3401521 tatggttttc acaccgcgaa taccggttca tatatttata acgatttcta attggagaga 3401581 gaataactat gaaactttta catgctattc aaacacatgc ggaaacttat ccgcaaaccg 3401641 atgccttccg ctctcaaggc cagtcgctca cgtatcagga attatgggag cagtctgacc 3401701 gcgcggctgc cgcgatccaa aaacgcattt ctggggaaaa gaaatctcct atccttgtgt 3401761 acggccacat ggagccgcac atgatcgttt ccttcttggg aagtgtcaaa gcgggacatc 3401821 cttatattcc ggttgacctg tctattccgt ccgaacggat tgcgaaaatt atcgaaagct 3401881 ctggagcaga attgctgatc catgcagcag gactctcaat tgatgcagtc ggccagcaga 3401941 ttcagacagt ttctgcggaa gaactgctgg aaaacgaagg cggctctgtc agccaagatc 3402001 aatgggtcaa agaacacgaa acgttttata tcatttacac ttccgggagc acaggaaatc 3402061 cgaaaggcgt gcagatttcc gctgcgaacc ttcaaagctt cacagactgg atttgtgcag 3402121 actttccagt cagcggagga aaaatatttt taaaccaagc gccgttctca tttgatttgt 3402181 ctgtcatgga cctatatccg tgccttcaat caggcgggac tttacattgc gtgacaaagg 3402241 atgctgtgaa taagccgaaa gtcttatttg aagagctgaa gaagtccggg ctgaatgtgt 3402301 ggacatcaac accttccttt gtgcaaatgt gcctgatgga tccgggtttt tcacaggatc 3402361 tgctgcctca tgcggacaca tttatgtttt gcggagaggt tcttccggtt tctgtggcca 3402421 aagcgctgct tgagcgtttt ccgaaagcga agatttttaa tacgtacggc ccgactgaag 3402481 cgacagtggc tgtcacatcg gttgaaatta cgaatgacgt catcagccgc agcgaatcgc 3402541 ttccagtggg cttcgccaaa ccagatatga acattttcat tatggatgaa gagggacagc 3402601 cgcttcctga gggagaaaaa ggagaaatcg tcattgcagg gccgagtgta agccgaggct 3402661 accttggtga gccagagctg acggaaaaag cgtttttctc tcatgaaggc cagtgggcat 3402721 accgaactgg cgatgccggc tttattcaag acggtcagat tttctgccaa ggacgtttgg 3402781 attttcagat taaacttcac ggctatcgaa tggagctgga ggaaatcgag ttccatgtca 3402841 gacagtcaca gtacgttcgt tctgctgtcg tgattcctta tcagccaaac ggaacagttg 3402901 agtatctgat cgctgctatt gtgcctgagg agcatgagtt cgagaaggaa ttccagctga 3402961 caagcgctat taaaaaagag cttgccgctt ctcttccggc atatatgatc ccgagaaaat 3403021 ttatctatca ggatcacatt caaatgacgg ctaacggcaa aattgaccga aaacgcattg 3403081 gcgaagaggt tcttgtatga cgccttacag ctcgttttta ttctttatac tgcttggcat 3403141 tcttcttctg ccgacgatca ttctcggctt aaacggaaaa agatttcaag catacaacat 3403201 gttcatatct atcattatat tggctttaat tttttcgcac gacttacacg gggtcatcgc 3403261 gctgtgcctg tttacaatat ggcaggtgct cctgatcagc ggctatctgg cataccggca 3403321 gaaagcgaac agcggctttg tcttttgcgg agctgttatc gcgtctattc tgcctttatt 3403381 tctgtcaaaa atatggccgt ttctttcaca cccgcagccg catcatccgc cgcataacct 3403441 gatcagcttt ttagggattt catatttaac ctttaaaggc gttcagctga ttatggaagc 3403501 aagagacgga ctgctgaaag aacagctgcc attgcaccgt ctgctgtatt tcatcctgtt 3403561 tttcccgacg atttcctccg gcccgatcga cagataccgc cggttcgtca aggatgaaca 3403621 gaaggcttgg acgaaagaag aatacgccga cctgctgtat acgggaatcc ataaaatctt 3403681 catcggtttc ctgtataaat ttattatcgg ctacgcgatc aatacgtact tcatcatgaa 3403741 tcttcccgca atcacgcaca ataagattct tgggaacctg ctgtacatgt acggctacag 3403801 catgtattta ttctttgatt tcgccggcta cacgatgttt gccgtcgggg tcagctacat 3403861 tatgggcatt aaatcaccag aaaactttaa taaaccgttt atcagtaaaa atattaaaga 3403921 tttctggaat cgctggcata tgtctctgtc attttggttc agagattatg tgtttatgag 3403981 attcgtattt tggatgacta agaaaaagtg gatcaaaaac cgtatggccg tctcaaacat 3404041 cgggtatttc ctgctgttta tgctgatggg ggtttggcac gggctcgcgc cgcaatatat 3404101 catttacggc ctctatcacg ccgttctgat gacgtgttac aactttttcg agaagtggaa 3404161 taagaaatat aaatggctgc cgtccaaccg ctggacaacc attctcgcta ttgtgatcac 3404221 attccatttc gtttgcttcg ggttttatat tttctcagga aaaccatttc atcaccacca 3404281 ttaaaggaga ttagaaagct atggatttta aacaagaggt attagacgtt ttagcagagg 3404341 tttgccagga tgacatcgta aaggaaaatc ctgatattga aatttttgaa gaaggtttgc 3404401 ttgattcttt tggaacagta gaattgctgc ttgcgattga aaaccgtttt gatattttag 3404461 tgccgatcac tgaatttgac cgggacgttt ggaatacacc taacaacatt gtaaatcagc 3404521 tgtctgagtt gaaataatga aaaagcgttt tttcggtcca attattttgg cgtttattct 3404581 attcgcaggc gccatcgcaa ttccatcttc atggctgaca ggcttcatca ccgataagcg 3404641 tgtgaaagag tcagcaacag ccttgaatcc gagtatgttt caagggctat atttacaaga 3404701 tcagatgctc aaagatccga catatcttcc gatttacggg tcttctgagc tttctcggct 3404761 ggacgagttc cacccatcta attattttca ggtaaacaat gagggattca cgccatacct 3404821 tgtcggcaaa ggcggatccc agtcattgat tcattcttta aacttcgctg cccacatgga 3404881 tcagctgaag ggcaaaaaaa tcgtattcat cgtgtctccg caatggttta ttaagcgcgg 3404941 gtctgatgaa cagcatttcg cgccgaacta ttctgcgctg caagggcttg atttggcatt 3405001 taacgatcag atcgatcctg aaattaaaaa gaaaatgatg aaacgcatgc ttcgctttaa 3405061 ggctgtgcaa aacgatgcca ttctttctga gctgtacaaa gcaatggtaa acggtcagac 3405121 gtggaaagtg aacgcgctga agccggcggc gaaagtgtat tacagcatgc tggaaaagaa 3405181 agatctgtat tattcaacga cagaatcatc cgggccaaag cgctatatct cgcagtcagt 3405241 aaaggataag tcatggtctg aattgaataa actagcggat caatcgggca aacgccactc 3405301 cggttctaac gattttcaca tcgacaaccc tgtctataaa aagctgaagc cgaaagtgcc 3405361 taagctgaaa gggaaaaaca aaggaagatc gtatgcggtg tcaccggaat atggcgactt 3405421 tgaaatgatg ctcgatatcc tgaaggatgc gggcgcagag cctatgtttg tcaccattcc 3405481 tgttaacggg aaatggtacg attacacggg cttcccgaaa aaaggacgca ctgactatta 3405541 caaaaaggta aataaacaaa tcagagcgaa gggcttccag gttgctgatt tctcagggca 3405601 tgaatatgac ccgtatttca tgaaagacac cattcacatc ggctggaaag gctgggtgta 3405661 tgtcgataaa gcaattgacg aattttataa aaccggaaaa gtcacttcat cctgagcatc 3405721 tcataggacg cggctgcata tttcctgcta agatttgtaa tagtaaagga atcacagcca 3405781 acttaattaa gaggtgttac atccaatgaa gatgacaaat aatacggttt taatcacagg 3405841 gggttctgct ggcatcgggc ttgaactggc caagcgcctg ctggaacttg gcaatgaagt 3405901 tatcatttgc ggacgcagcg aagcacgtct tgcagaagcg aagcagcagc tcccaaacat 3405961 ccatacaaag caatgtgatg ttgcagaccg ttcgcagcgg gaagcattgt atgaatgggc 3406021 tttaaaggaa tatccgaact tgaatgttct cgtcaacaac gccggcattc aaaaggaaat 3406081 tgactttaaa aaagggacag aggagctttt tgtggacggt gatgaaattg aacttaattt 3406141 ccaagcgcct gtccatttat ccgccctttt cacacctcat ttgatgaagc agcccgaggc 3406201 ggcaatcgtt caggtcacat ccgggcttgc gtttaacccg ttagctgttt atccggtgta 3406261 ctgcgcaaca aaagcggcac ttcactcgtt ctcgcttacg ctcagacacc agctccgcga 3406321 cacgagcgtg gaagtgattg aaatggcacc gcctatggtg gacacgggct taaaccaaaa 3406381 atcacgcgat aaacaaggcc tgacgtaccg gggcatttca tctgaagaat atgttcaata 3406441 tttcttggac ggcttgaagg aaggcaaaca ggagattaca aatgaacgtg ttgaaggtct 3406501 tcgggatgcc actcgcgccg attatgacag gttattcgag caaatgaaca cgcaggagaa 3406561 ttaatttctc ctgctttttt catatgaatt tcttacaaat ttgagcaaac ctattgcgat 3406621 tatttgttga aggtatacaa tagaatataa ttattttcaa ataagtttga taatataaac 3406681 aatttaacag cagggagatt gaccatgact aaacaaacaa ttcgcgttga attgacatca 3406741 acaaaaaaac cgaaaccaga cccaaatcag ctttcgttcg gaagagtgtt tacagaccac 3406801 atgtttgtaa tggactatgc cgcagataaa ggttggtacg atccaagaat cattccttat 3406861 caacccttat caatggatcc ggctgcaatg gtctatcact acggccaaac cgtgtttgaa 3406921 gggttaaagg cttacgtgtc agaggatgac catgttctgc ttttcagacc ggaaaaaaat 3406981 atggaacgcc tgaatcaatc aaacgaccgc ctctgcatcc cgcaaattga tgaagaacag 3407041 gttcttgaag gcttaaagca gcttgtcgca attgataaag actggattcc aaatgcggag 3407101 ggcacgtccc tttacatccg tccgttcatc atcgcaaccg agcctttcct tggtgttgcg 3407161 gcatctcata cgtataagct cttgatcatt ctttctccgg tcggctctta ttacaaagaa 3407221 ggcattaagc cggtcaaaat cgctgttgaa agtgaatttg tccgtgcggt aaaaggcgga 3407281 acaggaaatg ccaaaaccgc aggaaactat gcttcaagct taaaagcgca gcaggtagcc 3407341 gaagagaaag gattttctca agtactctgg ctggacggca ttgagaagaa atacatcgaa 3407401 gaagtcggaa gcatgaacat cttcttcaaa atcaacggtg aaatcgtaac accgatgctg 3407461 aacgggagca tcctggaagg cattacgcgc aattcagtca tcgccttgct taagcattgg 3407521 ggccttcaag tttcagaacg aaaaattgcg atcgatgagg tcatccaagc ccataaagac 3407581 ggcatcctgg aagaagcctt cggaacaggt acagcagctg ttatttcccc agtcggcgag 3407641 ctgatctggc aggatgaaac actttcgatc aacaacggtg aaacaggaga aatcgcaaaa 3407701 aaactatatg acacgattac aggcattcaa aaaggcgctg tcgcagacga attcggatgg 3407761 acgaccgaag tcgcagcgct gactgaaagc aagtaagaaa aaagccggcc cattacaggc 3407821 cggctttttt tacgcttcaa ttttgttgaa aaactgcggc agatacgctt tgtgcgcctc 3407881 tagcatttcg tctaaaatct gtttggccac agtatcggac gggacaagcg ggttaatcgt 3407941 catggcaagg agcgcagttt gatagtcacc tgtaactgcc gcttctgccg cgacacgttc 3408001 aaaggatttg atttgctgga caaggccgcg gacagacacc ggcaagtcgc cgacagcaat 3408061 tggcttaggg ccggttttcg tcatcacaca gttcacttca actgcggaat cgtctggaat 3408121 actcgctatt gcaccattat tgatcgtgtt caccggctga atgtcatgtt tatcattata 3408181 aatggagctg attaagttac atgctgcatc actgtagtaa gctccgcccc gtttttccag 3408241 ctgcggcggt ttgatcgcaa ggtttggatc tttataaagc tcgaacagct ctttttcgac 3408301 cttctgtacg acttcagcgc gggtgccctc cgtttgtgat gcttccagtt cgtgctccag 3408361 catctctttt gttttaaaat agtaacggtg atagccgcaa gggatgacat tgagcgcttt 3408421 taagaaatcc ggttcccatt cggcgcctga gatatttttc atcgtcatcg cgtttttcgg 3408481 gtcgcccatc gcctcgatga cttgctcctt cacacttacg ccgtccaaga aaacatccag 3408541 cccgaatacc atatggttca gtccggcaaa ttggacttct acgcggtcca catctacatc 3408601 aagcgctttg gctacgccca ttttgatgcc gattggaaca ttgcaaagac cgacgacttt 3408661 cttcaggttg gagtagcgaa gcaaggcttc tgttaccatg ccggcagggt ttgtgaagtt 3408721 aacaagccaa gcgttcgggc aaagctcttc tatgtccttt gcgatctcaa ggatgaccgg 3408781 aattgtgcgc aatcctttaa acagacctcc cgggccgttt gtttcctggc ctatcactcc 3408841 gtattttagc ggaatgcgct catcctttgc tcttgcctgc aaaagtccga cgcggaattg 3408901 ggtcgtgaca aagtctgcgt ctttcagcgc ctttctccgg tcgagcgtaa gatgaatgtc 3408961 aatcgggacg ccagcttttt caaccatccg tttggcgagt gtgccgacaa tattcagctt 3409021 ttcttcgccc tcggggatat cgacaagcca taattcacgg acaggcagct catcataccg 3409081 tttaatgaac ccctccacta gctcgggcgt atagcttgaa cctccgccaa tcgttacaat 3409141 cttcaatcct tttgtcatat gcttgctccc ctttgctcgg tgattttttc atataactca 3409201 atgatctctg cagccatatc cttcactgtc attgcattca ttaaatgatc ctgtgcatga 3409261 accatcagaa gcgtcatttc cgtcttttct ccgcccgctt cattttggat cagctctgtc 3409321 tgataatgat gggcttttga caattcttca gcagcgtctt gaagcttttt ccgcgcttct 3409381 tctgcgtcac cgcttttcgc agcggcaatg gcctccattg cggagctcct accgtttcct 3409441 ccgtgaagga tgatttgaaa aatgatttgt tccatttcct cattcacgcg attcacttcc 3409501 tttctctaca gagccgcttc tttgtcatct gttgctgcag gcgtttggac cagctccaga 3409561 tcgttttctt ctttcagctt ctgcttatcc cacattctga agaatggata gtagacaaca 3409621 aaggacacgg caatattaat ggcttgcatg accgcgcctg agacttttcc tcctgtcgcc 3409681 aagtagcctg aaaagatcgg cggcatggtc cacggcactg cgatacccgc cggtttggcg 3409741 acaaggccgg tgctcattcc gatgtacgtg agtgtcactg tgacaagcgg cgtgatgata 3409801 aacggaagta agagcattgg gttcatgacg atcggcattc cgaatataat cggttcgtta 3409861 atattgaaga tggccgggcc gaccgcaagc ttcccgagct gcttcatttg tttgcttcgg 3409921 gcgcgcagga acatcgtgac aaccagtgcc aatgtggcgc cgcttccgcc aatattgacc 3409981 cagatatcga aaaattgctg ggtgaaaatc ttaggaagct cctcaccggc ttggaatgcg 3410041 atccggttgg catccattgc gccgtaccaa atcggtgcca tgacgccgcc aacaatgttt 3410101 gcaccgtgaa ggccgcaggc ccataaaagc attttgacgg cttcggcgac aaggcttcct 3410161 ccaaggcttc ctcccagaat ggaaagcgga gtccccaata aaacgcttac aatattatga 3410221 aggctttcaa acggtgtcgc ttcaacaatc agccgggctg cccaaattag gaagatgacg 3410281 gcaaagccgg ggattaacgc gacaaatgac ttgcttaccg ccggcgggac accgtccggc 3410341 attttgaaga ctaaattgcg ctggataata aggcggtaaa tctctgtgga caccattgcg 3410401 ataatcatgg cgacaaataa gcctttgctt cccatgagcg aaagcggaat cccgccgcca 3410461 accatgattt ctttcgtcgc gccatccggc ataaacggca cttgataagg tgttgctaat 3410521 aaaaatgccg caagggaaat ggctccggcc gacaaggcat caacaccgta tttctcggcg 3410581 agccggtagg caatgccgaa cgcggcgaca agacccataa tttcaaaggt cgcgtcgact 3410641 gggtaggcca gtttttcaga ccaggagctg ccaaacgttt ttgccataaa ctcagcgtat 3410701 cccgggatcg ggaggttgcc aatgatgagg aaaaaggaac cgatgataat caggggcatc 3410761 gtgaggatga taccatcacg cagcgcctgc aaatgacgct gtcccgcaat tcttcccgct 3410821 ataggcatga ccttttcttc taagatctga ttgactttat tcacatagcc cgcccctctc 3410881 tatgacacat gtccaagctg ttcagctgat ttcagcactt ccgccccatt gcacgttcca 3410941 taatggacgg tattaatgac gtctaccgga accccctttg actctcctaa ttttttgagc 3411001 tgcggaagca tgtaacggac ttgcggaccg agaagcaata catccgcttt atcgatatga 3411061 ttttgtacag aatcgcctga aactgcccaa atggtatagt cttttccctg ttcctgcgca 3411121 cttttttcca tcttgctcac cagtaagcta gtagacatgc ctgctgcaca aacgagtaat 3411181 atattcatgt aaaagacccc ctagagtttg atcaattttg taatgtcctg ctgttgctat 3411241 catcatatta tgaaatcgct ttcataaaca ctcagggttt ttccgcaggc aacggaaaaa 3411301 aggtatatac aggctgtcag ctcagcattt tttggtcaaa cacatccgaa agctcttgat 3411361 atgaacggca tttgatcagc tggttcatcg ccgccgggtc atccaaaatg ctgccaagca 3411421 gtttatacat gctttgtaaa tccgctttgt tctccttttc gacacaaagc agacagacaa 3411481 attgaactcg ctgactctcc caatcgatcg gttttttgag cgtacaaacg gcccaaaacg 3411541 ttgttttcgt ctgcggaaca agcgggtgcg ggatggcaac aagattgcca aaacacgttg 3411601 gcgacatgtc ttctctttca aaaatggaat ctatgatttc ttcatcggca aagccgcatt 3411661 cgaccacttt ctgccctaaa aattgaatca cttcttcttt tgagcgcaga tcctcctgaa 3411721 aaaaaacgag ttcttttttt aggtagcgat tggctttttc cttttcatca ctcagaatag 3411781 attctatttt tgtaaagtca gttccgccta agatggtgtt aaccttcagt actggtacag 3411841 ggagctcttt tttaatcgga atggtgctga tgacaaaatc aattgattcg taggacattt 3411901 gatcaagact ataatactca gccgttccaa gaatatcgag ccgcttgccg aaatgggaac 3411961 gcagtttttc gcgcagaagc tgggcgcttc cggctcccga tgcgcataca atgatacagc 3412021 gtttcggcgg gctttctgtt ttttttcgtt caatcgcggc gccaaagtgg agagccaaat 3412081 atccaatttc gttttcatga atctcaatac ccgtttgttc ctttatcacg attccggcaa 3412141 tgatcccggc ttcaaaagcg agtggataat gttccttgat cgctgccagc atcggatttc 3412201 gaagattcat gccgtatcgg ttgcggctga tcgccggctt catatgcagt gccaagccga 3412261 ttttcagctc tttgtcatgc aggatgccaa gcttcagttc acgatcaaca gctttgatca 3412321 tggcaagtgt cagctgatcg gtttcctctt ctattgaaaa tgtgtcctct ccgcattgtg 3412381 attgtgtcat tcgttttgtg ccaaggagat gcatggtgat gtaggccgtc tcgtctttcg 3412441 gaaacgtaac ggaaagcttt gattccagct cttttacgat ggcttctgca gcctggtact 3412501 ccttttgatg caggatatga tccatatctt tcgggaaaag agaaacatag ttttccgttc 3412561 tgatccgttt acaggcgata gcgatatgga taatgaggtt attcagtccc atgttggaca 3412621 gagggatgcg gtcgtttttc atttttttca agatggcgga acggatgatc tcaatttctt 3412681 cttttggcaa aatatcagcc ttttcattta aaacatctat ctccgtttct ctttcatcaa 3412741 caatgtactc cgccatgcag tacctcatct gcacctcgtc cccgcgcagc ttgaagccgt 3412801 aattcggacg tgtttccatg acgatgcggt aaggcagcag acgtttcttt acttccttta 3412861 aatccgtttg gagtgtagat tttgagataa atagttcttc agcaagttca tcgagcttga 3412921 gataatggtc cgccagcagc agacgtttca taagataggc cattctctcc tccggcaata 3412981 ccggcaggcc ctttttttgc tgaaattcat cttgcagcag tgttctgaat acttgctcgt 3413041 catcaatgcg gagcttgtag ccggagcctc ttacagattg tacaaaggca ccgtggccgc 3413101 ttagcacacc ttgaagttcc tttatatcat tgcggactgt ccgcgtcgtt acgtttaatt 3413161 gcgcggcaaa aaacgaactt gtcaccgggg cttcagccgc catcagcaag cgcagaatat 3413221 cacgtagtcg cccatgaagc atgagaaaaa cctcctaact agtagatgca gggattcagt 3413281 gaataggcag aaaggatgat gaagggatgc gaaatgtata taaattctat aatggagaga 3413341 atggcaagtc aatgaacatc cggaggacta gagggaaaac tgacctataa aaaaacagcc 3413401 gggatcagcc ggctgttcta gatgcggaca tattcttttg tttagacgcc ttgcggtcct 3413461 tcatgatttt tcgaacaatc gggtaaatga ccggcgccca tttgataacg gttttgatca 3413521 tctttttcaa agctccgatt ctcccttctt ttttctcaac cattcccctg attgcctctt 3413581 ccttaaacat gctaacgcga cacgtacctg tttcccgtca cccagaaacg ccatggataa 3413641 tcgcgtgcct ccccgctgtt gtcaatgccg atgcgcgggc cggttgaaat tgcttccggt 3413701 gtgtacccgc tttcgatgta aagcggctgt tccgtgatcc agcgtccgta gtcattcatc 3413761 gtgacgccaa gcgctttcgt cagctttcct ggtccgtttg tccattccct cggactcctg 3413821 cccggccttc tctcctccat taacagctgg ccttcatgcg gctcaatcgc cctgattaat 3413881 actgcttgcg ggacatcctc ttccgccgca acgacattca gcaatgtatg ggtgtgcatc 3413941 acgtatgtat atacccgccc agcttctgca aacatgatct cagtccgctt cgtccggcgg 3414001 ttgttaaagc tgtgggccgc tctgtctcca gcccccatat aggcctctgt ttccacaata 3414061 tagcctgacg ctgtgccttc gtctgtttct tttacaagaa ggcagcccag aagcgatggg 3414121 gcaagctcaa gagcggtttt ttgataaaac gtgatgggca gcggattttt ttctctcgtc 3414181 acgaatcgac ctctcctttt accgattttt gtacattgta ccattcccga agcagatcaa 3414241 aaaaaacggc tgttttaaaa tctttccatt cagggaatat tgttaccgtt caaaaaagga 3414301 gggccaacca ttgaaagatg atcatcaaaa caagcagcac caatcaaatg cccaagggag 3414361 cgaggaagcg ttttctcata agacatccgg gaaaaacgag tcagaggata ccttaacgaa 3414421 taggcagggg catcctgtta ctgacaacca gaatgtgaga accgtcggga atagagggcc 3414481 tacaacactt gagaactatg attttctcga aaagatcagc cacttcgacc gggaacgcat 3414541 cccagagcgg gttgttcatg ccaggggagc aggtgcacat ggatattttg aagcgtacgg 3414601 aagcttcgga gacgaaccga tttcaacata cacaagggcc aagctctttc aggaaaaagg 3414661 caagaaaaca ccggcatttg tccgtttttc aactgtgaat catggaaaac actcgcctga 3414721 aacattgaga gacccgcgcg gttttgctgt aaagctatat acagaagacg gaaactggga 3414781 tttggtcgga aacaacctga aaatcttttt tatccgcgac ccgctgaaat ttccggatct 3414841 tgtacacgca tttcagcctg atccagtgac aaacatccag gatggtgaac gtatcttcga 3414901 tttcatttct caatctcctg aagcgacaca catgatcacc ttcttgtttt cgccttgggg 3414961 cattccggcc aactaccggc aaatgcaggg ttcaggcgta catgcctata aatgggtgaa 3415021 tgaggagggc aaggccgttc tcgtgaaata ccattttgaa ccgaagcagg gcatccgcaa 3415081 cctgacacag aaggaagcag aagagattca agggaaaaac tttaaccatg ccacacagga 3415141 tctatatgac gcgattgaaa atggcgatta tccagagtgg gaagtatatg ctcaaatcat 3415201 gagcgatgat gagcatcctg aactggactt tgatcctctt gatccaacaa aactgtggta 3415261 taaagacgat ttcccatgga aaccgatcgg caaattggtt ctgaacaaaa atccggaaaa 3415321 ctaccatgcg gaagtggagc aagcttcatt tggaacggga gtgcttgtcg acgggcttga 3415381 tttttcagac gacaaattgc tccaggggcg tacgtttgcc tactctgata cgcagcgcta 3415441 ccgtgtaggc gcaaattacc tgcagcttcc gatcaactcg ccgaaaaagc atgtcgccac 3415501 caaccaggaa ggcgggcaaa tgcaatatcg ggtcgataga gcagaaggac aaaacccgca 3415561 cgtcaactac gagccatcca ttatgggcgg gctgaaggaa gcgaagcaag acggaaaaga 3415621 ccatacgccg catgtcgaag gtgatgtaaa gcgtgaagcg attgacagaa caaacaactt 3415681 cggacaggct ggagaaacgt accggagatt tactgaattt gagcggaacg aattgattac 3415741 gaatttggtg aatacgcttt ctacgtgccg aaaagaaatt caggatcaaa tgattgagaa 3415801 tttcacaaaa gctgatcctg actacggaaa acgcgtagca gaagggctaa aaaaggtctc 3415861 cgaaaacaac agcaacgggc cgatcggcac aactgaaacg gaacaggctg caaagcaggc 3415921 tgaacaggag agtcatccgt ctgatccgta ttaacaacag cgaacagggc ttttttagaa 3415981 gccctgtttt tttatttttc tattgaaacg ctttcaataa ttgtgttgta cttggaagga 3416041 aaggggtgga gagatacgat ggaattacag caggacttga ttcctcagaa aaaaacaatc 3416101 ggcgctttag atcacgccgt ttttttatgc atggtatttt gtttctggtt ttcaggctat 3416161 atttacgttc ctgtattcag tctgtatttg gaggatctgc acttttcata tggcgcaatc 3416221 ggcatcattc tcggcagcta cggggtcacg caaatccttc tgcgattccc gctcggcctt 3416281 ttgtcagaca tcctgttttc cttgcgcaag caattgttaa ttgccgggtt cggcttttcc 3416341 gtcctcagca gcctgctttt tctgatgttt gattctttct tcttcgtgct ggccgcccgg 3416401 cttttcgcgg gaatcactgc ttctacgtgg gtgatggcga ccattttata cgcacattat 3416461 ttcaacaatg gcaatgcatc aaaagcaatg ggcatcatgc agttttttac cgtcatgcct 3416521 cagtttgcca gcattgtgtt ctgcgggctc gccgcagccc atttagggag gcaggttcct 3416581 ttttggatgg cgctggcagc ttctgccgca ggtctggtga tctgctgctt tattcaggat 3416641 ccgtctgctc ctcccgcaaa ccgtggcacc attcgtgtca atcagtacat caaagataca 3416701 ttgcggctgc caaagctgaa gcttttcacc atcctgtcta tgacggccca tgccgtatta 3416761 tttatcacag tgtttggttt tacgccgctt tacatgaatc agctcggaat gggcgacgcg 3416821 gagctgcttt gggtgatgag cgcctttttc ctcccacacg cagccgccac attaagcttt 3416881 gtgtttctgc gctttacaag ccgtatcgct tactccgtga tgctcattag tttcgctgtc 3416941 accggggtct gtttgctata tgttcctttt ttagctgcat tgttcacggt ttgcatcaca 3417001 cacgcctgta ttgggctggc gctcggcttc gtttttcctc tgctgctaag ccatgtcgtc 3417061 gaaatcagtt ctgcccgttt aaaaatgtca gtgatggggt tttaccaatc attttatgcg 3417121 ctaggcatct tcctcgggcc ccttcttgcc ggaaaaatcg cacagcttat cgggcttgcg 3417181 ggagtttttt atggagccgg ttctctggca tttgccgcct tttttgtgat gctcgcgcaa 3417241 aaacgtaaca tgatcaatta atagctttca taccgccgga agcgccacac agaaaacacg 3417301 gccagaagca tgatgcacag aatggagaaa gtgagtgacc atccgaaaaa atctgcccgc 3417361 tctccatgaa gaaggatatg ctccgcctgc ttgcaaatct cagccggaag ccacttcgca 3417421 ccatctggaa atagtgaaac agcaaaggaa acggctgctg tgagcccgat cccgcaagcc 3417481 gcagctgctc cgacagaccg gaatatcgta cttccggcaa ggccggcggt cacaataaat 3417541 atcacccaaa gagcgtaaag gccaaggctt gcggcaaagc ggctgaatga tgcgtcctca 3417601 aacagcagcc ggacgtaata gtaagcaagc ccgtatccag ctgcaaacga cataatgccg 3417661 atcacgcttt ggatgagcca tttactcacg atataatggg ctgccgtcac aggccgcgac 3417721 ataatcagcg ctgttacccc ttgatttctt tcattggcta cactgcccat cacgctaaag 3417781 atgaccagag ccatgccaag cgtgttgaat tgagaaagcg tgctgaccat cacttcagac 3417841 ccggagggca tcgtaaaact gattttcatg ccgtcaggaa ggttccctcc atgtgcgatg 3417901 atttccggca tataataaat ggtcagcggc tgtgtcagcc cgacgatcat catcgcaatc 3417961 ggcagccaaa tcagcttgcc gcttttccat ccttccagcc actccttctg caatagcgcc 3418021 atcatcacct tcatgcgtgc accaccttta gatagacgtc ttctagagac tccgttttct 3418081 gttcaaagcg ggtgacggtc aatccctttc ggatacagtc acttaataat gaccggccag 3418141 cgtgtatatc aggcagctcg aaaaccgctt gggacggatt cttatagaca atagctgaga 3418201 cgtaaggctt ctcttcaagc caaccttcca gcttctcttt cactgaaagg gtaaaaacgt 3418261 tcgtttgctg ctgttgtttc agctcctgta actcgccttt ccatgaaatc tcaccgtttt 3418321 tcataatcac cacttgatca cacacctgtt ctgcatcgtg caaaacatgt gtagaaaaca 3418381 gaacggccat atgctttttc agctcccgca tcatgtccag cacctcgaac cgtcctgtcg 3418441 gatcaagcgc agacaccggt tcatccaata tcaaaaactt cggtttatgg agcagtgcct 3418501 gtgccagacc gagtctttgt ttcatgcctc ctgaatagcc cccgatcctt ttgtgcgccg 3418561 cttcgtgcaa accgacaaat tccagcatct cgccgatttt ctcttggcat tttctcttcg 3418621 aaaggccgga cagtctcccc gcaaatgtca aaaattcatt tgcggtcatc cacgaataaa 3418681 aagcaggata ctgcgggagg tacccaatca aacgccgatc cagctttttc tctcctaaca 3418741 gctttatggt tccagaggtt ggcgaaagca gtccggccag catttgcaga gtcgtggttt 3418801 tgccggctcc attaggtcct aatagtgcga cacactcatt ttcattcacg tgaaaactga 3418861 cattctttac agcttcatgg tgcctgtacg atttgcataa tgattcaata gacagcatat 3418921 cggcttacct ttgctttctg ccgacggtga aaaataaaat cggcccgata atattgatac 3418981 atacgatgat tgcagcccac atccactttg gcccgttcgt ccgctcttct tttatacagc 3419041 tgataagggc aaacaccgcc aaagccagct gtaatacaat cagcggcaaa atcatttccc 3419101 aagaaatatt cattgcttga tccccctttt cttccgatcc ggcctaatga caaaaaagta 3419161 ataacaaatc agaggcatcg gtgcttgaat caatccgaca atcccccaaa cccatgccat 3419221 gtgattacgt tttttcgcat caataaataa aaagattccc tgcgccaata cgatgagaca 3419281 agccgcaacc gttatgataa tttctgtttg tgtcatccgc gtttcacctc gcattcgccg 3419341 agatgccttt ttttctcagc cgcaatcaaa atcggcagca ccgcaagcac acaaacctga 3419401 agcacaataa acacagcagg agcttgagtg aaagctaaga ttgcagcact cacaaccatc 3419461 agcgcgcaga atacaaataa aatgatctct tgaagaagtt tttttctgta ttcagctttc 3419521 atttgtgaca gctggtgaag cagttctttt tgattcggta tagagggatt ggctgtttga 3419581 tcaatttttt tccattctga ctttaaatga tcagaaagct tttctttatt catcatccca 3419641 ctcctttctg atttgctgga gccctttatg aactctggac tttacagtgc cttctttgat 3419701 ttgaagcatc accccgattt cagcgtaggt atagccgtag taatgcctta ataaaaccgg 3419761 tgtgcgcagt ttagggtcca gctttgaaaa cagatcgagc gtttcgctcc actctgcccc 3419821 tttcgccgac acgtcccact tgatcttgcg gattgtttcc tccgtaactg tctgattccg 3419881 tttccattct ctctttctct ttttctggtg atcgagatag agccgcgatg caatggagat 3419941 cagccatgtg gagaattttg aacggccctg aaagcttctt aaatggatgt accctttcag 3420001 aaaggtttcc tgaacaagtt cctcgctgag atcggggtga agggaaagct ttaacaagta 3420061 tttatataag aaagaatagt gatagtggaa aagggctgta aacgcctcgt cgtttccctc 3420121 tttcgcctgc tggatcagcc gctgttcttc ttgtgtatcc aatgaccgtg atcccccctt 3420181 ttttgttttt ctgccttatg agacgacacc ggattcaaaa gcgttcatct tttttacaat 3420241 tcttttcagc cattgacaga tcaggcttcc cggccgtttg gctgcatatc cttatttgta 3420301 aaccccctta tagtctgtta agctatgact ttatgtcgat ttcaaaaaaa catccaatat 3420361 ggaggacgat gcattgaaag tagaaaggcg aacgattgaa tatattccga atgaagaaag 3420421 acatggtaaa gcgaaagatt tatttcccgt atggttcggg gctaatatgc atatcaccac 3420481 gttagtgacc ggcacgattc ccgttgcaat gggacttaat ctgttttgga gtgttgccgc 3420541 tattatttgc ggaaccttaa tcggtgccat atttatggct tctcattccg cgcaaggccc 3420601 tcagctaggc atcccgcaaa tgattcaaag ccgtgcccaa ttcggcgtaa tcggagcgat 3420661 tcttcccctc ttcttagtca tgtttatcta ccttggtttc ttcgcaagca gcacgattct 3420721 ggcggccgga accttaagca gctttgttcc catcccggga tcatggagca ttataggctt 3420781 aagtgccgta tgttttttac tcaccatttt cggccatgat ttgattcaca aaatgcaaaa 3420841 aatcctttct tggacctctt ttgctgtatt ttttgctgca acgattctca tttttcaatt 3420901 gccgattccg gcaggcagct ggatacccgg agcgattgat ctgccaattt tcctagtggc 3420961 agtcagcgca gttgcgacgt ggcagcttgc ctacgcgccg tatgttgccg attattcaag 3421021 atatctgcca gttaaaacac cggcttcaaa aacattttgg tacagctatg caggtacatc 3421081 tgtcagctcc atctggatga tgctgctcgg cgcattgctg acaacctcac ttcctgactt 3421141 tacggcaaac tcaggcagcc agattgtcca attgttcggt cccttctcgt ttattatgct 3421201 gatcattgtg ctatttgggc aaatggcaat caatgttttt aacctgtatg gggctttcat 3421261 gtccacgaca acaacgctgg agccgtttct gaaattaaaa gtcacgccca aagtcagaat 3421321 catcatgatc ctgggtgtca cgcttgtcgg cacagtctta agcctactgg gacagagcaa 3421381 ttttatggaa ctgtttttga attttatctt tttcatcagt tatttcttaa ttccgtggac 3421441 ggcaatcaat ttagtcgatt actacttcgt ccgccacgga aagtatcaag tcaaagccat 3421501 gttcgacgta aacgggcctt atggaaaggt caattggatc accacaattg cgttcgttct 3421561 gtctatcttg ctggaaattc cgtttatcaa cacaagcttt tacatcggac cgcttgccaa 3421621 aatgtttggc ggcggagaca tcgcatggat tatcggcttg gccgtgcctt ctgtgcttta 3421681 ctatgtatta atgaaaccgc gtctgaaaaa acgggcgggg tatcaagaaa agctgtcttc 3421741 tctctgaaga cagctttttt atcattcaaa tcgtttccac acgcggggca ggatgtcaga 3421801 tagctcatga gcgagcaacg tatgagcgga gtgctcgtcc gtccagagct cggcgcacgc 3421861 accatgcaaa tagaccgcgt ttaatacggc gtgctttgga tcttcatggc agcagagcat 3421921 ccccaatatc atgcccgtca gcgtgtcacc ggttccgccc ttggcgagcg ccccgtttcc 3421981 ggttggattg agccagcagt ctccatcagg aaacgcgatg acggtttggt ttccttttaa 3422041 cacaatgaca gtctgcagct gagccgccca ttcctttgca tattccgctc tttttttctg 3422101 caattcgttc acgggcaccc ctgtcattcg gaaaaactcg cccgggtgcg gcgtgaggat 3422161 gacggggccc tcccgtttcg gatatgtgcg cttcgccagc gctccggcat ccaaaataac 3422221 aggacaatca gccgtaagca catgatcgac tgcctgctgt acgctttccg tttgcggaag 3422281 gcccggtccg atggcaatgg cccggtacgt ctcttcaagc tgagcatccg ccgccttttt 3422341 ccagccgtca cgccaatagg tcgcctcggg caaaacagga acaattagcg ggattacgtt 3422401 ttctgatgta ccgatgacaa gcttgccgag accgctccgc atggccccaa gccctgcaag 3422461 cagcgctgct cccggcatgt cgtcacttcc agccagcagc aaagccgtac cgtacgtgcc 3422521 tttatggctc tccgcatctc tttcaggaag cgtggccctt acatgctctt ccgtccaaaa 3422581 tggaacattc atctctatcc ctcctctgct ttcttttcct atttttcctg tcccttttct 3422641 ttttcaaaca aaaaagacag ccttttaggg ctgtctttta ttttacagga acatcaaggt 3422701 gatacaggcg gcgatatcgt tcgtttgccg ccagcagctc ctcatgggtt ccttccattt 3422761 ctgttttgcc gttttcgaga aatacgattt tatcggctgc ttccactccc gcgagatggt 3422821 gtgtaatcca taaaatcgtt tttcctttca gcacctcaaa caccgtttcc atcaattcac 3422881 gttcggtaat aggatcgagg ccgactgttg gctcatcgag gatgatgatc ggtgtatcct 3422941 gcagcaaaat cctcgcaagt gcgatccgct ggcgctctcc accggaaaaa cggatgccgg 3423001 tttcttgtac agaggtatga tatccgtcag gcaatgactc aatgtagtca tgcagcttga 3423061 cctgctttgc ggcgcggcgc acatcctcgt cgcttgcttc tccgtttccg agcctgatgt 3423121 tgttcaaaat gcttgtatca aacaggtgcg gtttttgatt taacacggcc accgcatccg 3423181 caatctgatc ctttaacagc gctgtctcca ctccgtttaa cgtcacagaa ccggagtccg 3423241 gtttcaaggc gccttcgatt aatgcaagcg atgttgattt cccagagccg cttcggccga 3423301 gcagcgccat tttttctcct tggcgcagcg taaaggaaaa gttgtgcagc acttggctgc 3423361 tgttgtcata agaaaacgtc acatcacgaa aggccaaggt gacatcttga agatcgagaa 3423421 tttgatcccc tgattcagtt tgtgacgcct ccggctgagg agccacattg ttcatgcgtc 3423481 tgatagaatc ctgatagccc ggcacttcgc ctaaggcatc cgaaagcggc aaaaaggctt 3423541 ccgtcaacgg aaacaccact agcacaaaag cggcaatcat cgttttagcg agctcgccgt 3423601 ccgcttgctg tcccgctgtc caaaacagca tcagcaaaat aaggccagcg acaaggcatt 3423661 gcgcagcaaa gtcccgccat cttgtaaagc gttgtttttt ccgttcaagc tcaaaccaat 3423721 cacgttcctc tttttcataa gcatcaataa aagcatgccg gcgtccgctg aacatccagt 3423781 cgctgacacc catcacagca tctgtcagac ggctgtacag cacattccgt ccgcttttca 3423841 gcttcgcatt cttcgctctc gtcacgagca aagacacaac cggaaacaat acaacaagaa 3423901 caaacaaata cagcgcaagc aatatggcaa acggccaaga gaagaagccg agcgctatca 3423961 ctgacacagc atacaggagc aaggctgaga tcgcaggaaa aatcgttttt aagaaagcat 3424021 cctgcaaatg ctcaatatcc tcagacaaaa tgccgagcat atcccccgtg cgaaaacggg 3424081 aacgcagcat caaagcaccc ggctcaagca tattgtaaag gcggacgcgc atgtcagata 3424141 cgattttcaa aatgatgtga tggccgacga gccgttccac atatcgcgac acagagcgcg 3424201 caatcccaaa ggtgcgcaca gcgacaatcg gcacataaat gagcagaatg ttttccggcc 3424261 ttgtcgccgc tttagaaatc aaaaaacctg aggtgaacat gagaaaagca gcagaaaaaa 3424321 tcgtcaccgc acccaaaaag ataaccagaa cgaacaggcg ggcattttgc ttgatatacg 3424381 gcaaaatcca ttcttctttc ttcatgctct ttcccccagt tgtgccttca cgagtttggt 3424441 atacacaccg tttttctcca gcagttcatt gtgagtccca atttccgcaa ccctgccccc 3424501 gtcaagcacg ataatttcgt ccatatcgag catccagtga aggcggtgag tcgcgagaaa 3424561 gacgagctta tcctcaaata aatccagcat cgtttctttt atttcatatt ctgtttcgat 3424621 atcaagatgg gcggtcggct catccagcag caggatcgga cggtttccca aaaaggcgcg 3424681 ggccagcgcg acacgctgtg cctggccgcc gctgagcgcc cggccgcctt ccccgatccg 3424741 cccctctaat ccgtcaggaa ggttgttcac cagctccgtc agtcccgctg aggcagcagc 3424801 acgtgttgta tcctctgccg aagcgcttgg atggtagaag cgaatgttgt tgccaagcgt 3424861 atcatcaaaa atgtacggat gctggggaat gtaaagaagg ttcttctgcc agctgccgtc 3424921 ctgcaaatgg gaccggcttg taccattaac ctcaatcatc ccgccatccg gctctaaaaa 3424981 tccgccgaga atatcaatta atgttgattt tccggcgccg cttgcaccga taatgccgat 3425041 ttttttcttg cctttgaatg agagatgaat atcagacacc gaacggccga ctgacacgcc 3425101 tgacagcttc agctcatcct gatcggacca agcttcgagc tgaagcggcg tctcttcttt 3425161 aaaaccaggc tgcgacaaaa tctcttgaat ggtttttcct gcttcctggc cgttcagcgt 3425221 tgcatgataa tcattcccca cttcccgcac cggcaaaaaa tactcaggcg ccagaataag 3425281 cgccgttaaa gcagggccaa gcaaaatatc gccgtcaatg aggcgcaggc ccagaaatac 3425341 tgcgactgtc gccaccgaca gcatcgtgaa aaaatcgagg gcgaatgatg acaaaaacgc 3425401 cacccggagt gtgctcatcg ttgccttgcg ataccgctca ctcacataga aaatattttt 3425461 gctgtgtgac ttgctcaaac ctaggaaacg caatgtctcc agcccgcgaa gagaatcaac 3425521 aaaatgattg gaaagtctct gataggattt ccactgacga tccgcttttc tctgcgcgac 3425581 aaggccgagg agaatcataa agatgatcag aatcggcata gcagcgacta aaatgatggc 3425641 tgatgtccga tcctgaaaaa acacataaat gacaactgcc gcaggcacaa tcgccatgct 3425701 gaccattttc ggcagaaaca gctccaggta gcggcggaac tggctgatgc cttccatcgc 3425761 cagcgtcacc atttgccccg tcccctcttt ctttgcaaag cgggggccta atcggaacag 3425821 ctgatcaaga aaacttttcc tcaaatctgc tcctgtccgg gcggcgtatt gatagacgat 3425881 tttctgtcgc gccaccgtca tcccgtgccg ggcgataaaa gcgatgagga aaaagccgat 3425941 caccggtaaa agggaggtaa tgcccttccc gttgaacagt ccggttacgg cctcactcag 3426001 ccactctgcc tgcataataa tggcggctgt ctgaatcaac gttaaacaag taatcaaggt 3426061 gagaatccgc ttcattcctt tatatcgaaa caggtctttt cccattaata agtcataggc 3426121 tccttatggc tgacgcgctt ccggaagaca taatagctcc agatctggct gccgatgacg 3426181 aacggcaata gcgttaatgc tgcaattgac atgactttaa gcgaataatc tccagaagaa 3426241 gcgttagcta ctgttaaatc gtatgcgcta tgaagcgagc tgaccattac acgagggaat 3426301 agggaaataa agatcattcc cacggtcagc gccagaccag cgcctgtcat cccaaatgtc 3426361 cagccgtctt ttttcttacg aataaataca gccgcgagca taaagcagat gacaatcaaa 3426421 acagcgagcg gaatggtaat ctcgccgcgg cgtgtaaaca tgtctgtctg atacgcagaa 3426481 agggccgcga aggcaagaac cgctacaaaa acaacaccca ttatcttttg cgccattttc 3426541 cgggcgcggt tttgcaaatc accaatcgta cgcagcgtga taaacattaa tccatgctgg 3426601 aagcaaagaa gcgttaccgt cacaccgcca agtatagaat atacattgat ataatcagat 3426661 acatgtgcgt gaatgttcat gtcggcatca atcggcatcc cgcggaataa tgtcgtgaac 3426721 agcacaccaa gcacaaacgg aggaattaga ctgccgaaaa aaacgaccca gtcccaaacc 3426781 tttacccatt ttaaatgatc caccttgccg cggaactcaa acgcgacccc gcggcccatt 3426841 aacgcaagca gcactatgac aaacggaatg taataaccgc tcagcatcgt tgcataccag 3426901 tttgggaatg ccgcgaaaat ggcgcctgcg ccagtcaaaa gccacacttc attcgcgtcc 3426961 cagaacggcc cgatcgtgtt gatcagcact ctgcgttcta attcattatg gccaagaaaa 3427021 cgggtcgcca tgccgacccc gaaatcaaag ccttccaaaa agaagaatcc tacaaacaat 3427081 acagcaacga gtataaacca aagatcatga agagatgcca tggtatacct cctgactaaa 3427141 tggatctgtt gatacaggca catcatgatg attatcatgc tccgcacctt ttttaatctc 3427201 acggataaac aagaagacaa gcagtgcacc aagaatcatg tacatcacac cgaatgcgat 3427261 gattgagaat aacaaggaac ccgctgttac gttaggcgac acagattgag cggttgtcat 3427321 taaccccata accgtccaag gctgacgtcc gatttctgtc ataatccagc ccgcggagtt 3427381 tgcaagaaac gggaaggaaa tcaacgcgat catgatgcgc aaataccatt tgctgttttc 3427441 aagcttttta cggcggttta accaaaggcc gcctaacgca gcaagaatca tgacaacacc 3427501 tgctcctacc atgatgcgga agctccagaa tgtcgttttc actggcggaa tgtagtcgcc 3427561 ttttccgtat attttttcgt actcagcctg aagggttttc atccctttga cacttccgct 3427621 gaatttctga taagccaagt agctcaaggc ataaggaact ttgatttcat ttgagctttt 3427681 ttcatttttt gtatcgatcg tcgcaaaagc ggtccaagca gcagggtcac cgctgtcttc 3427741 ccataggcct tcactggcag ccattttcat cggctgtgat tccatcaagt gctcagcctg 3427801 catgtgtccg ctaaggccga cgccaagacc ggcacaaaga ccgacgatca ttgcgagttt 3427861 aaaagattgc ttaaagaacg gcacttcttt tttcttcagc agtttaaaag cactcactcc 3427921 ggcaataaag aaagctccag tggcaagcgc accgaaaata acgtgcggga attcaaccca 3427981 aagctgaggg tttgtaatca acgcgccaaa atcattcatt tccgcgcggc cgtttttgat 3428041 cgtaaagccg accggctcct gcataaagga gtttgctgtt aaaatccaga aagatgacat 3428101 gatcgttccg aatgatacga gccatatgca gagcgcgtga attttcttcg gcaggcggtc 3428161 ccagccaaaa atccataatc cgataaaaat agattccatg aaaaacgcca ataatgcttc 3428221 aatcgcaagc ggagcgccaa atacatctcc gacaaaacgg gagtaatctg accagttcag 3428281 tccaaactgg aattcttgca aaatccccgt tacaacaccg actgcgaaat ttattaagaa 3428341 taagtgtccc caaaactttg ccattttgag atacagctca tttttcttta caagataaag 3428401 agtctccatc aacgcaacca taaacacaag cccgatagac atcggcacaa acaagaagtg 3428461 aaacaacgtt gttgatgcaa attgtatgcg ggctaatacc aattcactca tgctttctcc 3428521 tccatttccg gttaaaactg ttaatttgct cactacttca caaatagaac cgagactttg 3428581 atcagtaatt cacaaaatag acgaaaaaaa tattgctcaa tatttcacaa atgtgtcaaa 3428641 aagtcatcca atatgatgca agattgccag actgaccaaa tgacacaatc tctgactggt 3428701 tcatattaag tactttacaa cgattcattt caaaaataaa gcctaaaata cctaaaaagt 3428761 cccgcactat gtgacggatt tttgtctatt ttgttgctta tttatgtcgg ctgctaggat 3428821 aaatgaccct ttattatcgt acatcaacac atcgttcctt gcgaacaaaa tgcttgcccc 3428881 cgccccagca ctcgagtctc agcattccgt cttaaaccga ttttagtcag aatgcctctt 3428941 ttcatttgaa ccggtaagag gagaaaagtt gaatagtaaa tttttaatat attaataatt 3429001 tcaatttttt agtatactta acatagtgaa caatttcact gcatcaagaa taggggaggt 3429061 ttttcaatgg gagagcttca aacacacatg caattgcaaa cggatacaat tcacgaaggg 3429121 gttcgaaaag agaattggtt tgcgaaagcc atgaatataa aagtaggcat cataccgctt 3429181 cctgtgtatg ccttgctgtt tatattaatc actgtttttg ttatgcatca cgatgtaaaa 3429241 agtgacattt tgacatccat tgccgtcatg gcgtttttcg ggtttacctt tgcccaaatc 3429301 ggcaaatcga taccgattgt tcgttctatc ggcggcccgg ccatcctagc tacttttatt 3429361 ccgtccgctg tcgtgtacta tcacctgctg cctaatgata tcgtcaaatc caccacagaa 3429421 tttacagaaa actcaaactt tctatatttg tttatcgccg gtattgtcgt cggaagcatt 3429481 ctcggcatga aaagagaaac actcgtaaaa gcattcatga aaatctttat tccgcttatt 3429541 gtcggttctg tcacagccgc tattgtcgga ctggctgtcg ggacattgct cggactcgga 3429601 tttcagcata ccctgctgta cattgtcatt ccgatcatgg ctggaggagt cggagaaggc 3429661 gctatcccgc tgtccatcgg atattctgac atcatgccca tttctcaagg ggaagcgttt 3429721 gcacttgttc tgccatcgat tatgctgggc agcttgtgcg cgattattct agcgggattg 3429781 ctgaaccgaa tcggaaagaa aaaaccggaa tggacaggca acggcaaagt ggaccgctcc 3429841 gaagaagagt cccctgcgct ggaggaatct caaagcggac agcaaatgtt caacctttct 3429901 ttatttgcgt caggcggtat ccttgctgtt tctttatact tagtcggcat gctcgctcac 3429961 gattttttcg gttttccggc acccgttgcc atgctgttac tggctgttct aatcaagctg 3430021 ttcagattgg tgcctgcctc aattgaaaat ggcgcgtttg gagtgtcccg cttcttttca 3430081 acagctgtga cctacccgct tctctttgcg attggggtat ccatgacgcc gtgggacaag 3430141 cttgtcgccg cttttaacct cagcaatatt atcacgattc tgtctgtcgt tgtgaccatg 3430201 atggccgttg gcttcttcac tggaaaatgg ctgaacatgt atccgattga aaccgccatt 3430261 attaatgcat gccattctgg gcaaggcggc acgggtgacg ttgccatttt aagcgccgct 3430321 gaaaggcttg agctaatgcc tttcgcccag gtgtctaccc gcatcggggg cgcgattaca 3430381 gtatccttaa ccttattgct gctgcaccag ttttattgat ccccgcaagc aagttcttcg 3430441 tcaaacgaaa gagcttgctt ttttgcatgt ccatgttttt gcaagttccc atcccatgct 3430501 atagtaatag ttggaaatac tagatagaaa ggaatctggc atgcctatgg gaactcatct 3430561 atttctcttt atgcttctcg ggctgggatt ttatttgata tcagccctag ctgcaaaact 3430621 cattccggcc atagacttct ggattgatat tgttctatgg gtcggcgctg cggcttacat 3430681 cttctctcat ctctcattca tggacggcat tgtctcactc gcgacaatgt tctactgcta 3430741 ttggaccgca atggatctca ttgtttcaga gcgtgtggaa aaaccttcgg gagactggca 3430801 ggaaatcgag cttgccaaaa acaaaacacg cctcctgtca gacattacgc tgaccgccat 3430861 tgtgtttgca ggggctgtca tttttttcat ctatggacct gacacaagcc ctctcaaata 3430921 tgtgatcctt ctcggaatga tctccggcgg aggggcactt gtgaagcgaa tactgaatgt 3430981 ttttagcgta aaggtttttt attcagcagc cttagaaaaa ttgcatatca gctcacacta 3431041 tgaaacccgt acatacccgc tttccgattt gaagaacatt cagcttgaat caacagcaga 3431101 tctcttaaag ctccatccgc ttctgacgat gtattcatcc cgtttagatt tgacaacaag 3431161 ctttcagcaa gtcattaaac tgtctcttcc cggcgaaaca ctgtttctga cggtgaagga 3431221 accgcaaaaa tggaaaacaa ttcttcagga atacacagat gcagaaaaca atgtggacaa 3431281 tgtgatttct gttttgccgt tttatcatcg aaaaaatgtg aagcggctgc tcggtaagct 3431341 ttattttgcc gccagcgtaa aaggggtatc cgcttacgcc ttattggtgc tcgcgttata 3431401 cgcattacac gcctctccat gggtcatggc tgttgccgta atcctatatt gggtattcaa 3431461 catgtatatg tcagaccgtg tgttgcgggc ggcgatggac gccaagtctt gtcatcatcc 3431521 gcatgtacag gccgcggccg ataagatttt cagatcggcc ggcatttccc atgtccgcat 3431581 atacgaaacg gagagtgatg attacaacgg aatggcagta ggcatgaatg tcgggaggtc 3431641 aatggtcatc ctgacaagcg ccacactaac acttccacag cgtgtcattg aaggcattct 3431701 ggcccatgag gcgattcata tcaaaaaacg tgacgttctg tcatcacagc ttttgcgttt 3431761 tctatatctt ggagctgtcg tggggatttt cctcttgttt gagcagcata tcacccatcc 3431821 cgaggcccac aaaattgcgc tttgggcttt cattatggca atcattatcc tattccagct 3431881 ctatcaatcc ttttgttcac aatggatgga ggtgcgtgct gacaaccttg gcgcatcatt 3431941 gctggacggc ggttacaaac aaatggctga agccttgaga atcttggcgg ttcggcaaga 3432001 tgaggatata cagaaacaaa gtgcctatag ctctgaagca ggtgaagacg agcttcaaat 3432061 tgattctctc acccgtgata aaagctggtt tttcagattg attgattttc agttcgctcc 3432121 tcatcctcct atgtattggc gtgtcggcac tttattgtca aacaaaggac atggggtgct 3432181 aaagcgctgg ctcagagacc gactgaaaga atcgatcact ttgaaatgaa accggtcagc 3432241 gtttcatccg tataacagat atggtgaaaa aagggagtga cgcgaagtga ttgtgatcat 3432301 cttattgttt atatctatta ttgtttttct ttcagtcatt cagccgcagc cctcgaaaaa 3432361 caaaagccgc cagcaggcgg acagcgggta tttcggttat tcagatcata gctcacacca 3432421 tgatggatgc agcagtgacg gaggtttcag cgattccggc tgtggcggcg gagggggcgg 3432481 cgattaaacg ccgccttttt ttatttcatt gattcgatgt acgcaccaaa agccgagcct 3432541 gacatgcctg gggacacgcg cacacgatgg agggcataca ttccctggtc tctcgaagcc 3432601 gcgcccggtt ctgtcgtcac gcccatttga tagcctgttt tttcagcggc cttcagcgtc 3432661 tcctcattgt agcgccctac cggatagctg atgatggtgg tttgctgatg aaacatgttg 3432721 tcgaacagct ttttcgaatc agccatctca ctttgctgct gttgaggcgt taatccgttc 3432781 agctcaaggt ggtcaatcgt atggctttca atcgatatgc cgtgctgtgc catttccttc 3432841 atttgttcct ctgtcagatg gtgcttatgt ccgatcgatt tgccgatcat aaaaatcgtt 3432901 gccttcatcc cgtacttttt cagcaccgga tacgcatctt gataattgtc ggtgtacccg 3432961 tcatcaaatg tgatcagcac gcacttctca ctcggttttt tatcctgcgt cagcatgaga 3433021 gatgcctctt tcggcgttaa tgtctgatag ccgttatcat gaagccactt catatgcgcc 3433081 tcgaattctt tctttggcac acggaggctg tttcctgaag aaatgctgtg gtacatcaaa 3433141 atcggcagct ttgccggttt ctctgttttg atccatgcgg atgtatcgtc ttcttttttc 3433201 tgaacttgta ctgccttttt ttccggtttc ttttgttccg cttttggcat cggctgctct 3433261 gcattcgcct cttgatcagc acaagccgca agagccaaac agctgcccaa aagaaagatg 3433321 cttaaaaaca atcgtttcat cgttctcctg ctttctgtct atttcttcct cctttttcat 3433381 cggtttgatt ctgagatttt caatagcaaa aaaccggaca tgtctccatg tccggttttt 3433441 ttgatcttat cggattctca cttctgtctc actgtcaaag aaatggcctt tattcatatc 3433501 aaatgcaacc gtcagctcat cgcccgattg aatatcgagg cgggcgtcga tccgcgcaat 3433561 aaagtcttgg ttgtctatct gcgaataaat cataatttca gaaccgagca gctctgcaac 3433621 attaattttc gccttaatcg aagagttctt atatgattcc acgacaatca attcatcatg 3433681 tatatcctca ggacggatgc cgaagatgac ctctttgccg atgtagcctt tttcacgcag 3433741 cactttcatt tttccttccg ggacggttaa tgccgcagaa ccgattttga ttaagccatc 3433801 cgtgagcttt cctttgaaaa aattcatcgc cggtgatccg ataaacccgc cgacaaagac 3433861 gttttcaggg aattcatata catccttcgg cgtcccgatc tgctgaattt tcccatcttt 3433921 catgactaca atccgtgtcg ccattgtcag cgcttctgtc tggtcatgcg tcacataaat 3433981 cgttgtagtc tgcaatctct ggtggagctt aatgatttcc gcccgcattt gcaccctcag 3434041 cttcgcgtcc aggtttgaca aaggctcatc catcaggaac acctttgcat cccgcacgat 3434101 tgcccggccc agcgcaaccc gctgtctctg tccgcctgac agcgctttcg gtttacggtg 3434161 caaatattcc tcaagcccga gaattttagc ggcttcttcg actctttttt tgatttcagg 3434221 cttcggcatt ttccgaagct tgagcccgaa cgcgatatta tcgtagaccg tcatatgcgg 3434281 ataaagcgcg tagttctgaa ataccatcgc gatatccctg tcctttggcg ctacatcatt 3434341 gacccgtttt ccttcaatat aaaaatcacc tttcgaaatt tcttcaagtc ctgcgaccat 3434401 tcgcagcgtc gttgatttcc cgcagccgga cgggccgacg aatacgataa attccttatc 3434461 ggcaatatga aggttaaagt catcaaccgc cggttccttc tgatcataaa atttataaat 3434521 gtgctccatc cgcaattcag ccatctaaca tccccctttg ttattgtaaa cgctttctta 3434581 tattgagtgt aacagcaatt ccctctcgct aaaatgggca gcgttcataa aatcacccag 3434641 ccatttttcg tgcatatttc caatttattc tgaactttca ttttgcaggc agataaaata 3434701 ggcaagaagc gcgcctttgt acgatttgat atctatccct gaccgctcaa taaatttatc 3434761 aatccgatat tgcaggctgt tgcgatgcag atgcagcttt ttcgctgtta atgtgacgtt 3434821 tgagttgttt tcaataaaca gcttaatggt cttccttagc tcagattcac ttccaaataa 3434881 aagctcagct tcttcagaga gcagtgtttc cagtttttct ttttctgttt ctaataatag 3434941 aaaaggaaag atcatctcaa aggtcacact ctgcacctga ggcagccgtt tttcagcaaa 3435001 caggaaatac gcctgttcac gagcgtaatg ttttcgcaga cactcatccg gctcgtaaaa 3435061 tcttccggcg taaaaacgga cactgaagta gaaatcactt tcaagaacct tagcgagcga 3435121 ttccagttcg tccttctccg ccgccgcttc actttcctgc tcgacaatca cacctctgtc 3435181 ctcatggatc cacacaatca caaaagacac cggccaaaaa tggcgaaccg cttccgtaaa 3435241 ggacgtcctt tctattttgc cgaataaatg aaagtgaaca aatctcgtcc gtttctttat 3435301 atacgccggc aattcccctc tggaaaaaag gaacgaaaac cacttgtttt cctcaggtga 3435361 tttcatagac agttgattgc cctcatccgc aggcgtcaaa aatgactgca gcaccaatac 3435421 ttctttttca ctgatctctg ttttcggaat ggagatatat ctctgattgc tctcatcaaa 3435481 aaaacataga cagccttccc ttatgcaaag ctcctcagac acaatcgaac cgggataaat 3435541 agccagcagc gatttcatag agtctcctct cttatgtaag gatctgtata ttcagtataa 3435601 ggcgaaacac acatgttctc cactaaaaaa gagtatatcc ggtatagata gacgagaaac 3435661 tgaaagggaa acctcattcg tttacatatt ggcttcagcg gaaatagaag aagacatgca 3435721 ggaccaaagg agggtcatct tatgagtttc gaaacgttaa acaaaagttt tatcaacgga 3435781 aaatggactg ggggagaaag cggacgtacg gaggacattt tgaatccgta tgaccagtct 3435841 gtgatcacaa cagcatcttt ggcaacgggc aaacagcttg aggatgcgtt tgacattgca 3435901 cagaaagccc aaaaagagtg ggccaagagc acgacggaag accgaaaagc cgtgctgcaa 3435961 aaagcgcgcg gctatttaca cgaaaaccgt gatgacatca ttatgatgat cgcccgcgaa 3436021 actggcggaa cgatcattaa atcaacaatc gagctggaac aaacgattgc gattttagat 3436081 gaagccatga cgtatactgg tgaattaggc ggcgtcaaag aggtgccatc cgacattgaa 3436141 gggaaaacca ataagattta ccgccttccg ctaggtgtca tttcatcgat ttctccattt 3436201 aatttcccaa tgaatctatc catgagatcc attgcgcccg caattgcgct gggtaacagc 3436261 gttgttcaca agcctgatat ccaaactgct atttccggcg ggaccatcat tgcgaaagcg 3436321 tttgaacacg ccggtcttcc tgccggtgtc cttaacgtca tgctgacgga tgtaaaggaa 3436381 atcggggacg gcatgctcac caatccaatc ccgagattaa tcagctttac agggtcaaca 3436441 gcagtcgggc gccacatcgg tgaaatcgcc ggtcgcgcct tcaaacgaat ggcacttgag 3436501 ctcggcggca acaatccatt tgccgttctt tcagatgcgg atgtcgatcg tgctgtggat 3436561 gccgcgattt tcggaaaatt tattcaccag ggacaaatct gtatgattat caacaggatc 3436621 atcgttcatc aagatgtata cgatgagttt gtagaaaaat tcaccgcccg tgtcaaacag 3436681 cttccgtacg gcgatcaaac cgatccgaaa accgttgtcg gcccgctgat caacgagcgc 3436741 caaatcgaga aagcgctgga gatcattgag caggcaaaga cagacggcat tgagcttgcg 3436801 gttgaaggaa aacgcgtcgg aaacgtgctg acgccgtacg tctttgtcgg tgcggacaac 3436861 aacagcaaaa ttgcccaaac ggagctgttt gccccaatcg caaccattat taaagctggc 3436921 agcgaccagg aagcgattga catggcaaat gatactgaat acggcctcag ctctgcggtt 3436981 ttcacttctg atttagaaaa aggcgaaaag ttcgccctgc aaattgacag cggcatgacc 3437041 catgtcaacg accagtccgt caatgattcg ccgaatattg cctttggcgg aaacaaagca 3437101 agcggtgtcg gccgtttcgg caatccgtgg gtcgtcgagg aatttaccgt gacgaaatgg 3437161 atttcgatac agaagcaata ccgcaaatat ccgttctaaa tgaaaaaatc cctctgtttc 3437221 aagtacagag ggatttttct ttatttagat atatccacaa acccttcgcc aaacacatcg 3437281 cgtacgtcat gtacgatcac aaacgctttt ttgtcgcagc ttctaatgat ttttttcagc 3437341 atagacagct cctgtttgtt aatgacgata tacaaaatct cttttgactg gcccgtataa 3437401 tttcccttcc ctgataaaat cgtcacgccc cgatccatca aggtatttac ctgctctgca 3437461 atctcactct tattttctga aatgaccgta atggcttttt tcgtattcaa accttcaata 3437521 atgaagtcca tcactttggt accgatatac agcatcacga tcgtaaacat cattttttct 3437581 gcaccaataa taaaataaga gctaaatact acgattaaat caaaaaacaa gagtgcatag 3437641 ctgatattcc agtctaaata tttattagca attctggcca gaatcgcgga accggccgtc 3437701 gtcccgccga cccggataat catgccgatc ccgactccgg caaatacacc tgcgaaaatc 3437761 gtattaatga tcaattcatc agacggaatg ctccacccat gtgtcagatg aagaaaaagc 3437821 gaatttgccg caaccgcaat gatcgtataa accgttgttt ttccatcaag aaacttgtag 3437881 ccgattaaaa gcaaaaacgc atttaagata aagttcgtga caccaggaga ccattgaaac 3437941 agataataca aaatcagcgt aatcccagtg actccgcctt ccccaagatc attgggaatc 3438001 gcaaataaat taaccgcaag cgcgaagaaa aaagcgccaa tcacaagcat aagtacatcc 3438061 agcattctct ttttcatcac gaaaacactc cttttcattg ttctgttcta gcaaataaaa 3438121 aaacccagga gaacgctctc gaaaaagagc agaaactcct gggcttttat cccaccgtgt 3438181 cataacagcc aagctgctat gtgttttctc tcggtcacag tccaatttgc attgcggaac 3438241 cctagaaaac cactgttttt atcatatcct tttcactttc caatattagc attataaggg 3438301 acggttcgaa ttggttcaag gggtatttgc ggagttttca tcagataagc tggaaaaaaa 3438361 tacgatttat ctattaaaaa agaacagata taaccgataa gaaaaaaagc atatatttta 3438421 caagcgaatg taactataaa tgataataat tataagaaat tcataatttt atattgacta 3438481 agagaaataa tataggcatt atagtacata tgtttcgtac attttattac ataggaggaa 3438541 atataatggc aggaaaacta gtaccctgta aagcttgcgg tcaagaaatt gcaaagggtg 3438601 taaaaaaatg tcctaactgc ggtaaggatc aacgtaactt ttttatgcga cataaaatca 3438661 ttacgtttat tctcgcagtt gttgtcatca ttattatcgg taatatgatt ggcggcggag 3438721 gcggctcaga agccacttcc aaaacatcaa gcagcagcaa agcagaaact gaaaaaacat 3438781 acaatatcgg tgataccgta aaaactgaaa aaactgaagt gacggttacg aaggtagagg 3438841 acagagatac tgtcggtact caatatgttg aaaagaaagc atctgaggga ggtacaattg 3438901 tagctgttca atatacaatt aaaaacgtat ctaaaaagcc gattagctct ttttcaattc 3438961 caactgttaa attagttgat gctgatggta cttcttatga ttctgatatt gatgcttctg 3439021 taaactatgc aactgagaca aaagttgata actctaaaat tttgagtgat ctaaatccta 3439081 atattaaagt aacaggtgta aaagcatttg aagttgacaa ggaagcttat gcaaaaggca 3439141 cttggaaact aaaattcagt aatgatgtta ttgtgaaaat caaataacag ctaacaaggg 3439201 tgcctgttta ggcacccttg ttctttaaaa aaggccttct caattgagaa ggcctccatt 3439261 cttattccgc actcttatac ccattcacat tagaagactg ccatctccag gaatcagcac 3439321 acatttcctc aaggccgcgt ttcgcttccc agcctagttc tcgcttggct ttcgcaggat 3439381 ctgcaaagca tgtggcgatg tctcccggac ggcggtccgc aaaacggtat ggaacctctt 3439441 tccctgacac tttttcaaag gctttgacca tttccagcac gctgtagcct gtgcctgttc 3439501 caaggttgta tgcatcggct cctgtagagt tcaatacttt ttccagcgcc ttgacgtggc 3439561 cttctgcgag atcaacgacg tgaatataat cgcgtacgcc tgtcccgtct tttgtcggat 3439621 agtcatttcc gaatacgctt aattgctcga gcttcccgac tgctacctgt gccacatacg 3439681 gcataaggtt atttgggatt ccgttcgggt cttcaccgat ccgtccgctt ggatgcgcgc 3439741 cgaacgggtt aaagtaacga agcagcgcaa cgctccactc attgtcggct gtatgcaaat 3439801 cacgcaatat ttgttcaagc atgagcttcg tctgcccata aggatttgtc gcgcctaatg 3439861 gaaagtcttc cgtaatcggc gatgtttccg gaacgccgta tactgtcgca gatgaactga 3439921 atacgatttt cttgacgccg tatttctcca tggcctcgca taaaataaac gttcctgtca 3439981 aattgttatg ataatatttg aggggaatcg ccacagattc gccgactgct tttaaccctg 3440041 caaaatgaat cacagcttcg atttcatttt cagcaaaaac ggaatctacc gcttcccggt 3440101 ccaataaatc cgcttcgtag aacgttaaat cttttcctgt aatctccttg acacggttca 3440161 gcgcttcagc tgaactgttg gacagattat caagaacaac aatctcgtag ccgctgttca 3440221 atagttcaac acatgtgtgg ctgccaatgt aaccggcacc gccagtaaca agtattgcca 3440281 tgatgtaaac cctcctaaaa aatgacctgt tttcattata tagtgtttag aaccggtcca 3440341 catccatttt taagaagttt aatcgtttat taatagtttt ttcatatttt ttagcttaaa 3440401 cccttgccag caattcgata gaggtttcag caagaatgtg ctctttcatt tcttgataga 3440461 gctcattcaa gtaaaagccc ggctgaagat tcagctcagc atctaaagca tagaccgtca 3440521 atgtatacgc atgatccttg tcaggcggtg tcggcccgca atactggtga atcacctttg 3440581 gatcgttgct tcccgcaagc ggtgaagcaa agctgttttg cccttgtatc atcaagtcct 3440641 gtctttcctc actcgcatgt tcaggaagct ctccgatgta agccggaata ttagccgctg 3440701 tccagtgaat ccagctgaat ccgcatacgg gaatggcgtc atgatcgatg aaagtaagtg 3440761 cgagcgtctt tgctccggac gggatgtcat caaaatgaat tggaaaggat acaaatgggt 3440821 ttccttctct cttatatttt tcatccgcgt attttgaata cttgtcatgt aaatatggat 3440881 ttgcttctac gtatatgttc atatgaatcc ctctctctat tttctcgttc tataggtata 3440941 ctaaacgaat cgatgtataa tcagtgataa acaaatacgc atgtaaacgt aacaatttgt 3441001 tatggataac ttgcagtgaa ggagatattt catggattta aaatggctgc aaacctttat 3441061 tgccgcagcg gaatcagaga gcttcaggga ggcggctgag catctgtatc tcacacagcc 3441121 tgccgtttct cagcatatga ggaaattgga agatgaactg gacatgaggt tgtttttgca 3441181 tagcggaaga cgagtcgtac tgactgacga aggcaggctc tttttgcctt atgccaaaga 3441241 aatgatccat gtttaccaag ctggaaagca gaaagtcagt caatggaaac aggggtacag 3441301 ccgatcactc acgctggccg tacaccccta cattgcgtcc tatatcttgc ctcgctttct 3441361 gccagcctat atccaaaaac atccgcatgt cgagctttca actcatgtgg ctggatctga 3441421 cgctattaaa caagcggtgg aacacaatga agctgatatt ggtttgtcgc ggaaagaccc 3441481 gaacaccaac actctttatt atcagcatat atgcgaaggt acgctttgtc tggcggctcc 3441541 tttccaagaa agcagaccgg atgctgcatc cgtcttaacc cgctatcggc tgctaacgca 3441601 tgatcatccg tcatatgggg atgccttttt agataacatc cgatcacatt acccgtatct 3441661 tcaaatgatg gctgtcgggc agacggatac ggctgtccac atgatgaaag cgggaatggg 3441721 ggcatctttc ctccctacct acattatcaa acaggaagaa gccgaaaaaa agctgatggc 3441781 tgtcagcacg cctgcacatc tagaattgcc tgcgtcccaa acgtttatga tgtggaaaag 3441841 aaacagcgaa gacattcagc attttcacgc catgttacat gactttatgc agcgcgaaca 3441901 agtatagagc tgaaaaatca atctgccggt tgacgttttt ctttcctatt ttcgctatgc 3441961 ttaatgcaga aaggatttga tgacatggcg atgagccctt atatttttat tgtattgatt 3442021 cttattattt tatcgatgta tcgagaaaga acggtaaagc ccgggaagtt gctgatcatt 3442081 ccactgttgc tcttatgggg cgtatctgca tcgtttcagc cggcgtattt tcattccgta 3442141 ttacatgtgg cgatcagcgg cattttatta ctgatcgggc tggcctgcgg gtttggcatt 3442201 gggaagatgg taaatgtacg gattcacccg gaaaccggaa aggtcacttc acgcggctca 3442261 cttgggagtg ttatcctcat tctagtgata ctttctttgc gcatggccgc gagaacatgg 3442321 ctgcctgaga gcaacgagat gtttattgcc attattcatt ctatgttctt cgttcccctc 3442381 ggcaccatca cagcccgcaa catcatgctt tacaaagcat acagacgact gaccgctggc 3442441 aaagtatcca ttcaataacc gaaagaagga ccagcatgaa cggacaaact ccggctcggc 3442501 actactacaa gaagcttgtg ccgagcctta ttctcatttt gaattgcata caatttttat 3442561 ctcatccaac taaggctgat cccattttgt tagcatttgt atttgcggta tacttagcat 3442621 tcatttggat cattccctat gtggcatcca ctgctgttag tttgagcata ttcatcggac 3442681 tctggctcct gaccgatttc ttttgggctg tttccggcca agagcagggt gccgcctatt 3442741 ttttgattgt atttttaatg atatatgccg cctttagact cccttcacgg ctatccttga 3442801 tcttcacagc atgtttaatt ggaggcaaca tattactcct atcctcacaa gggggaagct 3442861 tgaataccat catcagcaac atctcgatca tgctcggtct gtacgtcctc ttctcctcca 3442921 tgcgtttcag acgagaagcg agaagggagg ctgaacggaa tcatgctgaa ttggcaaaaa 3442981 tgcatgtgca gctggagcat gctcataaag aactccagaa agcgcatgca gagctgcagg 3443041 aggcttctgt tctttcatta aggtacgcgg tccttgagga acgtacaaga attgcccgcg 3443101 acattcatga cagcatcggt cacgagctga cttctgtgat tgttcagctt caatcccttc 3443161 cctatatcct taaaagcagc aaggaggatt cagaaaaagt cattcaaaat gtactgagtg 3443221 tcgccaggga gtgtcttcaa gaagtgcggt ctgttgttca ccaaatgggc cgtagtgaat 3443281 cgatggtggg gcttaccgct ttgcgggggc tcattcatca agtggaggaa cggagcggct 3443341 tgcacgtttc tttagatact gccggactgt cagaagagtc ttggcctcca aacgtgagcg 3443401 aaacgatcta ccgcatcttg caggaagcgc tgaccaatat cattcgtcac gctgacgctt 3443461 ctcatgcggc ggccgtcatt tctaatgaca agtcccatct ctatgtcaca atcaccgacg 3443521 acggacaatt caccggcagc cttacttatg gatttggcct gacaggaatg aaagagcgcg 3443581 cagaaaaagc aggcggttcc cttactttca gtgccgtaca gccgagcggc ctgaaaattg 3443641 agctgtcatt gccgctcatg acaacgaata aggagcaaaa agatgaacaa agataaaata 3443701 cgcgtagcgc ttgccgatga tcagccgctt gtgcgtgaag gcttccgcta cgtcatcaac 3443761 gcacagacgg atatgacggt ttctggcgag gccggcgacg gtcacgatat tatagcactc 3443821 gcaaaacaaa caaaacccga tgtcatcctc atggatgtcc agatgccgcg ttgctcaggc 3443881 atcgaagcgg cgaaagacat tatgtccgca cttccaaata caaagatagt cattttaacc 3443941 acctttgaca cggaagaata cgtatttgaa ggcatccgtg cgggcgcagt cggctatctg 3444001 ctgaaggata cacttcctga ggagttgata gatgcgattc gcgctgcggc cagaggcgag 3444061 gcgattttcc gtacagtcac agctgctaaa atcatcagtg agacatttcg ggcgaaacag 3444121 caaactcatg ccgaagaact ggcagagccg ttcaccaaaa gagagcttga ggttcttcag 3444181 caaatggcct acggactgag aaatgaggat attgctgaaa agcttttcgt cagtgaaagc 3444241 actgtgaaaa cccacgtgca ccgcatcctg caaaaatgca atgcccaaga ccggacacag 3444301 gcagtcgttt ttgccattcg aaacggtatt gtgcaataga aatctctcat cccgccatgc 3444361 taaaataaga caaaggagat gattggaaat gaaagaagaa atcattgaac ggtttactac 3444421 atatgtaaaa gtcgatacac agtccgatga atccgttgac acttgtcctt ccacacccgg 3444481 ccaattgaca ttaggaaaca tgctagttga tgaattgaag tccatcggca tgcaggatgc 3444541 agccattgat gaaaacggct atgtcatggc aactcttccc tccaatactg aaaaagacgt 3444601 gccgacaatc ggctttctcg ctcacgtcga caccgctaca gactttaccg gcaaaaatgt 3444661 gaatccgcaa atcatcgaaa gctatgatgg aaaagacatc gttcttaacg aacagctgca 3444721 ggtcaccctg tcacctgatc aattccctga gctgtccggc tataagggcc atacactcat 3444781 caccacagac ggcaccaccc ttctcggcgc agacaataag gccggtatcg ctgaaatcat 3444841 gacagccatg gattacctca tcaaacaccc tgaaatcaag cacggcacaa tcagagtcgc 3444901 ctttacgcct gatgaagaaa tcggaagagg gccgcacaaa tttgatgtga aacggttcaa 3444961 tgcatccttt gcctacacgg ttgacggcgg gccgctcggc gagcttgaat atgaaagctt 3445021 caatgccgct gccgcaaaaa ttacgattaa aggcaacaac gtacatcccg gaacagctaa 3445081 aggaaaaatg atcaactctg cgaaaatcgc gatgaagctg aacagcctgc tgccggcaga 3445141 cgaagcgcct gaatatacgg aaggttatga aggcttctac cacctgctgt cgattcaagg 3445201 agacgtagag gaaacaaagc tccactacat tatcagagac tttgacaaag agaatttcca 3445261 aaacagaaaa gaaacaatga agcgtgccgt tgaagaactt caaaacgaat acgggcaaga 3445321 ccggattctg ctggatatga acgaccaata ctacaacatg agagagaaaa ttgaacctgt 3445381 catcgaaatc gtcaacattg ccaagcaagc gatggaaaac ctcggcatcg aaccgaagat 3445441 ttcccccatc cgcggcggaa ccgacggatc acagctgtcc tacatggggc ttccgacgcc 3445501 aaacatcttt acaggcgggg aaaacttcca cggcaaattt gaatacatct cagttgacaa 3445561 catggtcaaa gccgtaaatg tcatcgttga gattgcaaag cagtttgaag cgcaagcata 3445621 acgccaaaag ccagtccaaa aaaggactgg cttttttgtg tgaaaatgaa acattttaaa 3445681 cacgtcctcc gtaaaacaag tatcaacaaa tgaggaggaa aaacaatgac aaaacatgca 3445741 atcgctgcca agagtctctt gaaaaaatgg atcatttcca ggccgcttaa catgaaaaag 3445801 aaatccagcc catttcaaaa aatcagaaaa atgttcaaac gcttcttcaa ataaaacatc 3445861 aaatccccta aatacaatcc gtattcaccc gtaccgccca aatgctccgt aatttgggtt 3445921 ttttgtgttc aattccgcaa aatagggtat aaaccaaaca agcaagaaaa cagcacccaa 3445981 aaacaggtaa ttcgaattac gtaaacttag gttaaaagtt atataaagga atttatttta 3446041 tcgtcgatag taactataga accaatcatc aacaagagca aacagcgtaa ttcaagacta 3446101 ttttcaggtc atcaggtaat actgttttag agggacagtt tcttgttatt tattgattta 3446161 gaattttttg aatacttttt ggcattttat ccgtacaata gagagtacca aaactttttt 3446221 tgggaggtat gtaatatgat cctatttatt atcatcgcat tatgcggcta tcttcttttt 3446281 tctttcagca aggacaatcg ccgcaaaccg caaaagacaa gccctctgcc agcagccgca 3446341 cctcatcaca acaacctaat cgaccttgac gccatccgcc aaaaacgccg gatgcatctt 3446401 tcctaattct atatttcaaa cgaaaaggct gctgaatcac gcagcctttt aaaattgttt 3446461 tgatttagag cctgaaacct tttcgccacc tatccgtaat ttcatacaag gcaaacccaa 3446521 aggagacttc agcaatgatc gagttattta tgaaacaaaa aatgttctca tttaaagatg 3446581 catttcacat ttatgaccgg gatgaacaag aaacattcaa ggtggagggg cgttttttct 3446641 cgttaggaga ctcattacaa atgacagact catctgggaa aacgctcgtt tccatagaac 3446701 aaaaactaat gtctttattg ccgcgctatg agatttcaat tggcgggaaa acagtttgtg 3446761 aggtaacgaa gaaagtaacg ttttccaaac cgaaatttgt gatttccggg cttaactggg 3446821 aaatagatgg tgatttatgg agggatgaat tccaactgac ggacggggaa aatgtccgga 3446881 tgtcagtgag caaaaagtgg ctcagttggg gtgattccta tcacttgcag attgcatacg 3446941 aggaagatgt tctgatttgc actgccatcg ctatcgtgct tgatatggtt ttatataacg 3447001 atgaagatga aagtattttc taaaaagcat tgacaattga tccaaaagta ataatattaa 3447061 gataattgaa atctgaatat gaagttgtac cttatcaaga gaggtggagg gactggccct 3447121 atgatacccg gcaaccgctg tttcaaacag aatggtgcta aatccttaag aacattgcgt 3447181 tcttgcagat gaggcggaga tttgatcgtt caagctcttc cttacacaaa ggaagagctt 3447241 tttacatgct taatatttca gaaaagaggc gaataacatg gctcaacaaa cgaatgttgc 3447301 aggacaaaaa acagaaaaac aacgcaaagc acctttccgc gccgatcatg tcggcagctt 3447361 gcttcgttcc gttccggtaa aggaagcccg gcaaaaaaaa gcggctggtg agatgacagc 3447421 ggaacagctt cgtgatatcg aaaatcaaga gatcacccgc atcgtggaaa aacaaaaaga 3447481 aatcggtctc gatgtggtaa cagacgggga attccggcgt tcctggtggc attatgactt 3447541 cctggaaggg cttgacggtg tggaaccgtt catcccggct gaggggattc agttccataa 3447601 cacaaaaacg aaagcgcgca gcatcaaagt gacgggaaaa ctcgatttta cgagccaccc 3447661 agcgctcggt gattatcaat ttttacatga gattgccggt aacgcgacgc caaaattgac 3447721 cattcccagt ccaaatatgc tgttttttgg cgaaaaggcg gataaaggga tttatgacga 3447781 tcaagaggaa tactttcatg atatggccca agcgtacaaa aaagcaatca aagccttcta 3447841 tgatgctggc tgccgttatc tccagcttga tgatacgtca tggtctctct tctttgagga 3447901 caaaggcaga gaggttgtcc gggcgctcgg cggtgatcca gaaacattgc cagccatatt 3447961 tgccaaaaca attaacgatg ccgtcgcaga ccggcctgac gatttaacga tcacaatgca 3448021 catttgccgc ggcaacttcc gctcaacctg ggcggcatca ggagggtacg acgctgtagc 3448081 ggaaacgatt ttggacggct taaaccttga cggccttttc ttggaatacg atgatgaccg 3448141 ctccggaaac tttgatccgc tccgttttgt gaagcgcaag gatctgcaaa ttgtgctcgg 3448201 cttgatcaca tcgaaatacg gcgagcttga aaatcctgag gatgtgaaac gccgtatcaa 3448261 tgaagccgcg cgttttgtca gcttggacca gctatgcctg agcccgcagt gcggtttcgc 3448321 ctctacagaa gaaggcaacc ttctgacaga ggagcagcaa tgggcaaagc tgcgccatgt 3448381 catcgacatt gccaacgatg tgtggagata atctatcatt gacagaaata gaaaatgtgt 3448441 gaataataga tactatcaga aaatttaata aaaaggtttt ccttatcaag agaggtggag 3448501 ggactggccc tgcgataccc ggcaaccgct gtttaacaga atggtgctaa atcctttaga 3448561 gcaatgattg ctcttgaaga taaggttgag attgtcacgc aagctcttcc ttatccaaag 3448621 gaagagcttt tttatatttg aatggaaaga aggaatggac aacatgtcac aacaaacaac 3448681 acccgcagaa caaaaatcac ttcaaagaaa aaaaccgccg tttcgcgcgg atcaagtcgg 3448741 aagcctgcta agatctgagc ccgtcaaaaa agcgcggctg caaaaagcgg ccggcgaaat 3448801 gaccgctgag cagcttcgcc aaattgaaaa cgacgaaatc atccgcattg tggaaaaaca 3448861 gaaggaaacc ggcctgaacg tcgtgacaga cggtgaattc cgcagagcat ggtggcactt 3448921 tgatttcctg gaaaacttag atggcgttga gccgtttact cctgagcaag gcattcaatt 3448981 ccataacgta cagacaaaag cacgcggcat taaagtcaca ggcgatatcg acttttcaac 3449041 tcacccaatg cttgaagatt actcatttct ccatagcatt gccggtgacg cgacgccaaa 3449101 gatgacgatt ccaagtccga atatgctgtt tttccgcgga aaactggaaa aggatgaata 3449161 caaaaacgat tatcaacttt tccagcacga tgtatccaaa gcatataaaa aagcgattca 3449221 agcgttttat gacagaggct gccgctacct ccagcttgat gatacagcgt gggccgtttt 3449281 cttatcagaa aaaggcttaa aacaaatcga agcgttcgga acaacgcctg acgagcttcg 3449341 ccagctgttt gcgaaatcca ttaacgacgc gattgcagac cgcccggatg acttgacggt 3449401 aaccatgcat atttgccgcg gcaacttcca gtccacttgg acagcggaag gcggctatga 3449461 cgcagcagcc gaaaccattt ttgacggctt gaatcttgac ggacttttct tagagtatga 3449521 tgattcacgc tcaggcggat ttgagccgct ccgttacgta aaacggtctg atcttcagct 3449581 tgttcttggc ttagtgacat ctaaattcgg tgagcttgaa aatccggatg acgtgaaacg 3449641 ccgtatcgaa gaagcgtccc gttatgtaag cttagaccag ctttgcctca gccctcaatg 3449701 cggattcgct tcaactgagg aaggcaacaa gctgactgaa gaacagcaat gggcgaagct 3449761 ccgccatgtg gttgagatcg ctaatgatgt ttggaaataa gcaaagaaaa aaacacactt 3449821 gattccctag cggagcaagt gtgtttttta tgtcattgtg cggtgtagcc cccatcaagg 3449881 acgacagcct gcccagtgac gcccttcgcc ttctcgcttg ccaaaaacac ggcataatcc 3449941 gcaatttcct tgacggaaag cagtcgcttt tgcggcacaa gcggaaaaat gacttgttca 3450001 agtacagagt cgtaagggac atttctagtt ttcgatagat cgctaagctg attgcgtaca 3450061 agctgggtat cgacataacc cggacagagc gcattgactg ttatgccgtg gggcgcgcct 3450121 tccagcgccc ctacttttgt gagtccaatg acgccgtgct tggcgctatt ataagcggat 3450181 ttccctgcaa agcccactaa tccattaaca gacgcaatat taatgattct gccaaactgc 3450241 tgttttttca tgatcggaaa aacatgcttc attgcaataa agggagccgt cagcatgacc 3450301 ttgatcagct gttcaaaggt gtctgtcgga aactcttcaa tcggagcgac gtgctgaata 3450361 ccggcattgt tcaccagaat atccaagcgg ccgtattgtt tttggatgac gttcaccgta 3450421 tcagcaactt gcgcttcctt tgtcacatca tacggaatgg ccgccgcgtc aaagccttct 3450481 tctgcaagct tggaggctgc tttttcacat gcttccggac ggaggtctga aacgatgacg 3450541 ctggcacctt cccgggcgaa ttctcttgcg atttcgaatc cgattccgcc ggcagcccct 3450601 gtcaccaaag cgacttgttt tctcatgtca aacaccttcc cattaagaat tgagtacaga 3450661 ctggcttaca gcgaaatcag cttctgtttt ttcataaacc tcttcaattg tgacaccatc 3450721 ctgaagctcc gtcagtgtca tgcggccgtt cacaaaatca aatacagcca aatccgtaat 3450781 cagcctgtgt acgactttct ggcctgtcag cggaagggag catgtttttt tcacctttga 3450841 ttcaccatgc ttattgacgt gctccatgat gacaacgatt cgtttcgccc cgttgacgag 3450901 atccatggcg ccgcccatcc cttttaccat tttgcccggg atcatccaat tggccaaatc 3450961 cccctgctcc gaaacctcca ttccgccgag aatagctaaa tcgatatgcc cgcctcttat 3451021 catcgcgaat gactcagcgc tgtcaaaata agaggcgcct gtcacttcag tgatcgtttc 3451081 ctttcccgca ttgatcaaat ccgcgtcttc cgttccttcc agaggatagg ggccaattcc 3451141 gagcaagccg ttttccgact gaagcatgac gtgaacgcca tcgggtatct catttgcgac 3451201 aagcgtcggc attccaatcc cgagattcac attcatgccg tccttgattt cttgtacagc 3451261 ccgtttgacc attcgttttc tcgcttcctt cacttggcct caccctttcc cgatgcttgc 3451321 tgaactgttc gtttttcaat ccgtttttct tggctcgcgc caagcacgac atgctgtacg 3451381 taaattcccg gcgtatggat gtgatctgga tcgagctctc ctgcttccac gatttcttcc 3451441 gcctcggcaa tcgtgatctt gcctgccatg gcggcaatgg gattgaaatt tctcgccgtt 3451501 ttcctaaaaa tcaaattgcc catggtgtcc gctttccacg ctttgacgat cgccacatcg 3451561 ccggtaatgc ctcgctccag cacataagtc cggccgccga atgttttatg ttcttttccc 3451621 tcggctatgg aggtgccgac gcctgtcgcc gtataaaatc ccggtatgcc tgcaccgcct 3451681 gcacgaattc tctcagcgag cgttccttgg ggaacaagct ctacctcaag ctctccgctt 3451741 aaaaactgcc gctcaaaaat tttattttca ccgacatagg aagcgatcat tttcttgatt 3451801 tgcttgttag ccagaagcaa accaagcccc cagtcatcga ctccgcagtt attgctgaca 3451861 acggttaaat cctttactcc ctgatctctt atagacaaaa tgagctgttc agggatgccg 3451921 cacagcccaa accctcccgc gatcagcgta tccccatcat gaatcagttt cgcagcttcc 3451981 ttgcttgatg acagcacttt tcccatattg atgccccttt cgttttcttc tacactagac 3452041 cagtcaggct gtaaatcgcg atcacagcaa atacggcagc cgttttaatg agcgtgatcg 3452101 caaaaatatc gcgataggat tgccggtggg tcaaacccgt cacggccaga agcgtgataa 3452161 cggcgccatt atgcggcagt gtatccatcc cgcctgatgc cattgaaatg acccgatgca 3452221 tcacctctgg cggaatattg taagcctgaa tcgcctgtaa gtattgttct gacatcgcgc 3452281 ttaacgcaat gcccattcct cccgaagccg agccggtgat tcccgccagc gcagttgtcg 3452341 taacggcgcc atttacaagc ggatcggtaa aagtatgtga aattccgctg ctcagcttat 3452401 gaaaccccgg cagcgcggcg ataatgccgc cgaacccgta ctcagcaccc gtattcatag 3452461 atgccagcaa ggcgccgcca attccttcat tcagcccttc cttcaattgg gcaaacacac 3452521 ttctccaatc aaataatatc gttgtgatga tgccaatcac taaagcaatc tccaccgacc 3452581 aaatagcagc cgctgaagaa atatcaagcc tgccgaactc ctttaatcct atggaagaaa 3452641 aatcaaatcc attcggatac cactttggca ggtaaatggt gaaatattta ttcactgcac 3452701 cgacgagaat aagcgggaca aaggcaagcg cgtgccgaat cgggcttttg tccggttcag 3452761 ccgcggactc aatcgattca ggagcaggag cattctgcga atcaaaaccg ccatagcctt 3452821 cgccagatgc ctgcgctttc ttccgccttg attccaaata gagcatccca gctgccagca 3452881 caatcactgc gcccatcaaa cccagccaag gggcggcata aatgtctgtt ttgaaaaacg 3452941 acgtcgggat gacattttgg atttgcggcg ttcccggaag tgcgtccatc gtaaacgtaa 3453001 aagctcctaa agcaatcgta cccgggatga ggcgttttgg tatgtttgct tcttggaaca 3453061 tgtttttcgc aaaaggatat acagcaaata cgacaacaaa caggctgaca ccgctgtacg 3453121 tcaagacagc acccatcagc acaatggcaa gtatcgctct ttttgccccg acaagccgga 3453181 caattgtttt cgcgattgat gccgcaagcc cggccatttc aacgaccttt ccaaaaatag 3453241 caccgagcaa aaacactggg aaatacagct taataaaacc cgccatcttc tccataaaaa 3453301 ttgatgaaaa aaaaggaagc acatggcttg gatctgtcag cagcaccgcg aataacgcgc 3453361 aaatcggcgc aaacaatatg acagaaaatc cccgatacgc cgtaaacatc agcaaaccta 3453421 acgccaatag aatgatgatc agttccacac acacatcccc cgtttccgcg aactagaaag 3453481 cgtttacaaa aacctgtccg catcggctgt ttccgtcccc tttccatatg tacgagaagc 3453541 gtgggccaac tattccgatt aaaaaaggaa agctcctttt ttcggagctt tcctctacca 3453601 ttcatttcat tcctattagg atatcaacat caaccgtaat atcggctgat ttcatctctt 3453661 tcagcaggct gactcgatct ttcggcgccg accaggcaag cggcgtcatc ttgagaagcc 3453721 agtggatcgc ctgctggtca agcgttttaa catagcgcag cctgacagga cggctgtgtg 3453781 ctgcatttgc tgtaaaacgc tcaactgctg ccgtattgga atacgtgcgc cttggtgaat 3453841 cagtatataa aaattgcctt aattctatta aatagtcgct tcgcggcact acttttatga 3453901 gcatgccatc attcttcagc agtctatgaa actctgcata attggacggc gaaaaaatag 3453961 acagaacaac atcaaattgg cgatcatgaa aaggagcacg cgccacatcg gcaaccgccc 3454021 acatcagatc tttgaatgcc ttagaagctt ttaagatccc gtccttcgaa agatctatgc 3454081 cggttcctat cgctgctttc cctgcataat caaacccgca aagcgcattc aaatgagaac 3454141 cctcaccgca accgctgtcc aagatggtga atgcctcatg accagatttg ggatgactga 3454201 tgagctctgc aatcgcatca tggagcgggt caaaaaaacc acattctcca atcagcctgc 3454261 tcctcgcttc aaaaagctcg gcaccgtaac tggttttgac cggcttcgtc agaaagttca 3454321 cgtagccgtg ccgagataga tcaaatgtat gtcctcgttc tgtacaaatc aagcttttcc 3454381 ctgatgccgc atccatagaa gaatcgcaga gcgggcatcg aaacatgctg aaatcaactg 3454441 ttcgcttcat gataaaaaac accccattca ttcattttta gataaatgaa aaaggcatag 3454501 acaaataaac ctaggcctat ctcaaaaatt ggccaggtct ggcagtttgt ctacacctgt 3454561 cattatctat aacgaatgaa ttggataatc atgaaaaaaa ctccctttct gctgtatggg 3454621 tttccccgtt tccatcatac aacaaatatc caggagctgg aaccttatag tgaagaaaaa 3454681 tcagtactga catgctggta tcccgccaac atcatatcag catagcaatc cagcatgttt 3454741 ttcctttatt ttctcatttt agaatataaa ttttattatt gtgaaaatag ttaaaaaggt 3454801 tgattttcaa aaagtgaaag gataaaatac tgctatcatc ttagaaaaag acattcttgt 3454861 atatgatcag taatatggtc tgattgtttc tacctagtaa ccgtaaaaaa ctagactaca 3454921 agaaagtttg aataaatttg aacgagttga aaaggacaag ttcttttctg tttgctctta 3454981 tttttcacac tttctgcact tccagaattt gtgaaggata agagcttttt ttgtttccat 3455041 aataaccctc ataggagttg ctatcatgta ctttttacta aaccttgtcg gtctcattgt 3455101 gattatggca gttgtattcc tatgttctcc gcagaaaaag aaaatcaagt ggcgcccgat 3455161 cattacgtta attgttctgg aattgctgat tacttggttt atgctgggaa caaaagtcgg 3455221 aagctgggcc atcggtaaaa tcggtgattt cttcacttgg ctgattgctt gcgccagtga 3455281 cggtatcgcg tttgcctttc cgtcagtgat ggcgaatgaa acagtagact ttttctttag 3455341 tgcgcttctt ccaattatct ttatcgtcac attctttgat attttaacgt atttcggcat 3455401 tttgccttgg ctgattgata aaatcggatg ggtgatttca aaggcttccc gcttgccgaa 3455461 attagaaagc tttttctcta ttcaaatgat gttccttgga aataccgaag cacttgcggt 3455521 catccgccag cagcttacgg ttttaagcaa caaccgcctg ctcacattcg gtttaatgag 3455581 catgagcagc atcagcggct ccattatcgg atcttatctt tcaatggtgc ctgcgacata 3455641 cgtgtttaca gccattcctt tgaactgctt aaacgcgctg attatcgcaa acctgctgaa 3455701 tcctgttcac gtgccggagg atgaagatat catctataca ccgcctaaag aagagaagaa 3455761 agactttttc tctacgattt ctaacagtat gcttgtcggc atgaacatgg ttatcgttat 3455821 tttggcaatg gtgatcggat atgtcgcatt aacgtcagca gttaatggca ttcttggcgt 3455881 tttcgtacat ggcctgacca tccagacaat ttttgcttat ctgttcagtc cgttcgcatt 3455941 cctgcttgga ctgccagtgc acgatgcgat gtatgttgct cagctgatgg gcatgaaatt 3456001 agcaacgaac gagtttgttg cgatgcttga cttgaaaaac aatctcaaat cccttccgcc 3456061 tcacaccgtt gcggtggcga cgacattcct gacgtccttt gcaaacttca gtactgtcgg 3456121 catgatttac ggcacgtaca attcgatcct tgacggagaa aagtcaacgg tcatcgggag 3456181 aaacgtgtgg aaactgctcg tcagcggaat tgcggtatct ttattaagtg ctgcgattgt 3456241 cggcctgttt gtgtggtaga aacattgagc catatccctt ttcggatatg gctcttttca 3456301 ttattgataa atagaggctg gcacctgcac atcccggatt cccgctgcat aaggccccaa 3456361 gtcatactgg ccgaagacga tggcgatccc gtttgccgta aagtaaaaca ttgtgtctct 3456421 gtttagggtt atatcctctt tctttacatc agagaaaaac agcacatcgt gttttttgat 3456481 atagctatat aggtaatctc tcgttttgct gacttttgtt ttggtgttca gaatctgatc 3456541 cagcgtcacc cgcttttgtg ctttcaagtc atagttgaag gactggacag acgttagacc 3456601 gtgggcgccc cctgaataga tataattgag tgtttgaatg ctgagcttgc ctgccgcatt 3456661 gtatttgacg ctgaaggatg tttgatattc ccgttttaaa gccctgctgt tcgcctgctt 3456721 ttttgttttt caggtattcc tgatacgatt gttcatgtag gctttcagct cttgattgat 3456781 tttcttttca aacgcggcat tcccgacgtg atgcacttgt ggatacgtta actccttgat 3456841 ctttttgtac gtatgggtgc tgacagtcgg tgttttcgct tgaactgctt ttaaagatgg 3456901 ggccgcatat gcaaatacag aaaaaagcaa gactgcaatg cccgcggctt tcagcatgtt 3456961 attccatttc atacaatcta ctcctttgat gtcgttgttt atcattccct tatttaagca 3457021 atacacactt ttatagactg attaaatcga aagaagtttc taggtctaac agcatgattt 3457081 ttccaataaa aaaagagaca caggatgtct ctttttttac tgtttgcgcc cagaaatcgc 3457141 ttcatgaagg gcttgtgcca aatctgtatt tccgaacatc tctaataccg caatgacagt 3457201 ctggtccgga atgtgctctg cttcgtgttt tggcacgacc agatcgtcca tggttttttt 3457261 caagctttca ttcagctttt gctgcggata cgctttggcg tacagctcca tcggatcaag 3457321 atcatggttc acgcaccact gggcaaacac caaaatcatc atattttcat cgcgttcgta 3457381 agcttcagtg agctgttttt cgttcatttg tcatgctcct tatgaaaagt atcttcctta 3457441 aagatacagg agccgatcaa attcgtctat cccaatggcg atgagcagca accgcatcga 3457501 taaatgcctt gctgaaagcg gtgtagtcag gttcatcttt agccgttacg atgcctagcc 3457561 cctctgttgt cccgacagag gattgaagaa ggtcaattcc ttcatttgcc gcaccgatcg 3457621 ccttgtagtg attgtaagct tctctgataa acgccatcgc ttgtttgttg tcttttaact 3457681 ccagtcctcc tgcggcatag acggcatcat acagaacaga atcaaccgtc aggaacgtgc 3457741 cgctggcctc aagctgctgt ccgctgccgc ttgtcatata ccccagattt tgactgatga 3457801 tatccactgt gattccttct tgctttaagg cttccagtac tgtttgcagc tctttttcat 3457861 gaaatccgtt tccggcgagt acagcgactt ttcttgttga cgcggttttc actgtacggg 3457921 cttggcttaa cgcaggcgaa gtaagaattt ctttagatgc tttacgcttc gcgggcgccg 3457981 ccacgcctac tcctttggcg atttcttctg ctaaatctgc atcgacattg ctgaagacat 3458041 caacgacctg ccgctgtacg tctttgcttt tgaccttccc gacctcgaag cagaaagcag 3458101 aaatgatgtg ctgtttctcc acaggagaca tgctgttcca gaaaagcttc gcctgtgagt 3458161 aataatcgtt gaagctgtcg cttcgctggc ggattttttt gccctcgact ttttcctgat 3458221 agtggacgta gccgccttct tcagctgtcg caggcgacgg atcattgttt tgcagtgagt 3458281 ttttatgata agcgacaggt cccttattga tcgtcatccg gtgatagccg tcgtattggt 3458341 tgttatggaa tggacagacc ggccggttaa tcggaatctc atggaagttc gggccgccaa 3458401 gacggatgag ctgtgtatcc gtataagaga aaagccgccc ctgcaatagc gggtcattgg 3458461 taaaatcgat gcccggcacg acatttcccg ggtggaatgc gacttgttct gtttccgcaa 3458521 acacattatc ctgattgcgg ttcagcgtca tttttccaat gatcttcacc ggcacaagct 3458581 cttccggcca cagcttagtt gggtcaagaa tatcaaaatc aaacttgaat tcatcttcct 3458641 catcaatcat ctgcacgccg agctcgtatt caaccttgcc gccgttttca attgtttccc 3458701 acaggtcacg gcggtggaaa tctggatctt tcccggcaat tttttgcgct tcatcccata 3458761 cgagagaatg cacgccgagc accggcttcc agtgaaattt cacgaaacgt gcctttcctt 3458821 gttcattgac aaaacggaac gtgtgaacgc cgaagccttc catcattctg tagctgcgcg 3458881 ggatgcctct gtcagacatc gtccacatca ccatgtgggc agactcaggg ttattggcga 3458941 caaaatccca aaatgtatcg tgagcagtcg cagcctgagg catttcattg tgtggctcag 3459001 gcttaaacgc gtgaaccaaa tccggaaatt tgattgcgtc ctgaatgaaa aacaccggaa 3459061 tgttatttcc cacaaggtca tagtttcctt cttcagtata aaattttgtc gcaaagcctc 3459121 tggcatcccg caccgtgtct gcggagcctt tagaacccgc aaccgtagaa aaacggacaa 3459181 ataccggtgt cttcaccgaa gggtcctgaa gaaatttggc ccgtgtgtat tccgtcattg 3459241 gttcgtaaac ctgaaaaaag ccatgcacgc caaatccgcg cgcatgcaca acgcgctccg 3459301 gaatcctctc atggtcaaag tgcgtcattt tctcccggaa atgaaaatcc tccatcagcg 3459361 tcgggccgcg aaccccggct tttaacgagt gctcatcctc tgacactcgc aagccttggt 3459421 ttgtcgtcat tttcttcccg ctgttatcgg tcctgtactg ctcaagctgc tcgtcctttg 3459481 agtgttcatt tacacgtttg ttttggtcat cactcatgtc tgctccccct ttttaaaacg 3459541 aaacattcta cagcacattt acccgtggcg ttcttcatat aaactgctaa tccgctcatt 3459601 aggatttttg gtctacatat aaatatgcgg tcatacacat ttgaaataag ccttcttcac 3459661 agaaagaaag gatggaagcg cttaccaaaa aagctgttga ataggggagg tcatatcatg 3459721 cttgccatac tcggttttgt gatgatgatt gtctttatgt accttattat gtctaaccgg 3459781 ctttccgctc ttattgcttt gattgtcgtt cctattgtgt ttgccctgat cagcggattt 3459841 ggcaaagatc tcggcgagat gatgattcag ggcgttacag acctcgcccc taccggtatc 3459901 atgctgttat tcgccatcct gtatttcggc attatgattg actcaggcct gtttgatcct 3459961 ctcattgcca aaatcttatc gtttgtcaaa ggagatccgt taaaaatcgc cgtaggcaca 3460021 gcggttctga ccatgaccat ttcgctggac ggagatggga caacaaccta tatgattacc 3460081 attgcagcga tgctgcctct ctacaaacgg ctcggcatga accgtttggt gttagcggga 3460141 atagcgatgc ttggttcggg ggttatgaat attatcccgt ggggcgggcc gactgcgagg 3460201 gttttggctt ccttaaaatt ggacacgtca gaggtcttta caccgctgat tcccgctatg 3460261 atcgccggca ttctctgggt gatcgccgtt gcttatatcc tcggaaagaa agagcggaag 3460321 cggctcggcg tcatttcgat tgatcacgca ccgtcttccg acccggaggc cgcaccgctc 3460381 aagcgtcccg ctcttcaatg gtttaacctg ctgctgactg tcgctctgat ggccgcactg 3460441 atcaccagcc tgctgccgct ccctgttctt tttatgactg cgttcgccgt tgccttgatg 3460501 gttaactatc caaatgtcaa agagcagcag aaacgaatct cggcgcatgc gggtaatgcg 3460561 ttaaacgttg tctcaatggt gtttgctgcg ggcatattca caggcattct ctccggcaca 3460621 aaaatggtgg atgccatggc gcattctctc gtttcactca tccctgatgc catgggcccg 3460681 cacctgccgt tgatcactgc gatcgtcagc atgcccttca cctttttcat gtcgaatgac 3460741 gccttttact tcggtgtcct tcccatcatc gccgaagccg cttccgctta cggaatagac 3460801 gccgctgaaa tcgggagggc ctccttgctg gggcagcctg tgcatctgct cagcccgctt 3460861 gtgccttcca cctatctatt ggtaggaatg gcaggcgtca gctttggcga ccatcaaaaa 3460921 ttcactatta aatgggccgt gggaacaacg attgtgatga ccattgcggc gcttttgatt 3460981 gggattattt ctttctaaat gtatgagctt gatcgtagca ttgagtgagt acgtgattta 3461041 cagaggggag aagatcaaat aggatattat gagtgaatag aagattcatg ccaacaactt 3461101 ctcattacaa tcataagagc ctgctatatt gcagcaggct ctttcacatt tggcattatt 3461161 tttttgtata gcgcacccag tcataatgag cgtatagcgg atttacacca ttgtaggagc 3461221 caagccattc atcgacaccc gtgccattcc acaagttcat catgatcttt ccaggtgttg 3461281 tcggaatttg gtttgttgca gtatgtttta attgcccgtc gacataccat ttaatagagt 3461341 ttggctgcca atcgaatgca tacgtatgat aggcattggc tgcatcaaac ccgagatcaa 3461401 caatcttctc atggtttcct gcaccatttg tataatagtt aaattgaacc ttcgttgtgt 3461461 cttttcctaa aaattcgata tcaatctcat cccaaggagt tccatctgtt ggacctgtgt 3461521 aagtgaagaa cgatgaaacg atccctgtgt ttttagctgg tttcattctg acttcataaa 3461581 gtccatagcc atatgtttga acagaacggt tttccccgca gtcaaacttg ttataagctg 3461641 ggcttgttag cgctaaacgc atttcaccca atgacgtcat tgatacgtta ttagcccgcc 3461701 acgtgcagtt gaacatattt ccattcgaat aaccatctgc tttttgccaa aaaccggagt 3461761 tatagccgtt aaaagggtca aaaaacgatc cacctgtttg agctgaggca gtagcagtga 3461821 ctgcaaacaa actcataaac aatccagtga caagaagcag caacactcgt ttcagataag 3461881 gcatattggc attccccttt cattgaaagc gttttctatg ttgatcttac atgattcttt 3461941 taaaagggaa catcggtcaa aataatgata atatcgaatc ttactaactt gaatcctgta 3462001 actatcatca tcttccctct gaaaaaaata aaaacctaaa ttaccatcag cacagacaga 3462061 gatgatccgc actcattgca atttaggttt tgcctgcttt atcagtaaca atcctaccat 3462121 tttcatatgt gaatgtaaga aaaagtgaac acaaggaaac acaaatgtca gcgctctcat 3462181 tatgcttgtt taactaccct ttctatgtga atggttaaat acagcagctc gtcacttgtg 3462241 agcttgtgct catactcccg ctcaatgtag gtttggattt tcttcgtgca ttcatacgcg 3462301 cgatgatact tttctttcac tgtatccagc aaaaaatcgt cctggctttc catgtgagtg 3462361 ccgttaaata gacgctgcgc gaaaaacttt aagtgggtga cgaaccgata atagtgaagc 3462421 gattcttcgt tgaattcaat cttaaaatgg tattttacaa tactcaaaat ctcttgcatg 3462481 acttttgtaa tgttgataat attgggcatc tcttcattca gctcggcatt tacaatatgc 3462541 agagcaataa agcctgcttc atcctctggc agagacacac cagtcttgtt ttttaccata 3462601 accaacgctt ctttgccgat cgcaaattcg tctttgtaga gccgttttgt ttcccacagc 3462661 aaggcgtttt tgatatcaag ccctttctgg ttgcgctgga tggcaaagtt aatatggtcg 3462721 gtcagcgaca catagatgct gtcgttgagc tttttgccga gctgtaattt tgcgtagctg 3462781 ataatctctt cggatacttc catacactcg atcggtatat catacaaaag ggttttgaac 3462841 ttttctgata catccttgtt atcgagcgtg aacactttct caatgcgggc ttcatcgaca 3462901 tcatcgccgg actttttctg aaacgcgagc cccctgccca tgacgaccaa ttctttcccc 3462961 tgttcattga ccacgctgat cacattattg ttgatcacct tcgcaatttt catggcatgt 3463021 ccctccaaat ctactaagaa cagactatat cttgattgta cattcttttt gtactaggtc 3463081 aatatcatca gggaaagacg gaagctggtc agtacaattc actccgtacc tgctgcccgg 3463141 gctgtttttg aagcagcgcc tccagatggc gttcaaatga tgccttgtca gctttctgct 3463201 ttttgacaat gctgttcatg attttaatgc tttcagcact gtattgtgta tattgttttt 3463261 tcagctgatc cagctgctgt cttgtcttct tcgcgttttt cggtgtgact tggttgatga 3463321 gtttgatcat actgtctgcg gtctcaaaaa aaccggctct attttctgtc agctgctgaa 3463381 tttcgatgcg gctcatatct tgattacgcg ttttttgaag caaggcaacc gcctcgctgt 3463441 tttgtttttt gagcgatttg ttctcaagct taatcgattc gagattctcc ttcgcaatgt 3463501 ctgcttcttc ttcagtcatg ctgattcgca cgaagtattc tggattgccg attccataat 3463561 caaatgcttc gctcacttgt atcatggaac tgaacacaat ggccagctgc ctgtcgcttg 3463621 cgagggcttg gaaatcctgc tttttcttac tgctcatcgg tttggctgcg gtttgtttta 3463681 ctgtcttttg atcacagtct gcgaacatct gagcctcacc ttcactttcg catgcgctca 3463741 tcacaagaac tgtgaccagc aggcttatac acaagcctat tcgcctcatg ctctgtctcc 3463801 tctctgctga atcccttctg gaaaatacca taaaatatag ttaaatggta ccagatgcac 3463861 ctaaccccag caataaatca aaagtatgat ttgaagcgaa aaaacataaa tattttgtaa 3463921 aaattgacgt gcattccatt cttttcaggc ccatttctcg tacaatagaa gtatcgttac 3463981 cggagagggg ctctgatgat gaaacgtttt acgaaacaag aaaacagctg ggtgttatat 3464041 gactgggcaa attcagctta ctcaattgtc gtgaccaccg cggtatttcc gttattttat 3464101 aaatcagcag ctgcggaaag cggtgtcagc gccgctcaat cgactgccta tctgggctat 3464161 accattgcga tttcaacgtt tattcttgcg atgctcggcc ctattttagg cacaatcgcc 3464221 gactatgaag ggtgcaagaa aaagttcttc ggtttctttg tgtcagccgg tgtcgccagc 3464281 accgcgatgc tcgcctttat ccctagtgaa cattggctgc tattgttgct gttttatacg 3464341 gtatcggcta tcggtttttc cggcgccaat gtgttttatg atgcctttct cgtggacgtc 3464401 acgcctgaga agcggatgaa tctcgtctcg gcacggggtt ttggcttagg atacattgga 3464461 agcacgattc catttatcat cagtattgct gtcatcctgc tcgcacaagc agagactatt 3464521 ccagtgtctg tatcggccgc aagccagctg tccttcttca taacggctgc ctggtggggg 3464581 ctgttcacca tcccaatgat taaacatgtc catcaacgct attacatcaa aaaagaacct 3464641 catattgtca tcaacagctt taagcggctc ggccaaacga tgaaacggat caggcaatac 3464701 cgggcacttt tcctcttctt gctcgcttat ttcttttata tcgacggagt cggcacgatt 3464761 attacgatgt cgacatccta tggatcagat ttagggatcg gctcctcaag ccttctgatc 3464821 atcctatttg tcacccaggt agtcgccgcg ccgttttcga ttatatacgg aaaactggca 3464881 gaacgcttca cggggaagac catgctgtac gtcgggatcg tcatttatat gatcgtctgc 3464941 gtgtatgcct attttatgga gacaacgctt gatttctgga tactggctat gcttgtcgcc 3465001 acctcgcaag gcggtattca agccctaagc cgttcctatt tcgccaagct tgtgccaaag 3465061 cgccacgcca atgaattctt tggcttctac aacatttttg gaaaattcgc ctcaattatg 3465121 gggccgctgc tcattgccgt taccgcccag ctgaccggta aatcctcgac tgcggtgttc 3465181 agcctgatca ttttgtttgt gattggtatt gtgattcttg cctttgttcc cgaggaaacc 3465241 agcacagatg tcagccagca gcaaaatgac ctgccccttt aactgggagc aggtcattca 3465301 tcatttattc gctttattca ccttcagctg tttccctttg acggttgtgt tcttcatcac 3465361 tttgagaaca tgagggcctt taccatttaa aatctcaacg tatgaggcgt tatccatgat 3465421 cgtgatgatg ccgatgtcgt cagctgacac accgtcaatt ttggcaatcg ttcctacaaa 3465481 atcaacggct ctgattttct ttttctttcc gccgttaaaa tacagcttca taatgtcttt 3465541 attcagctct tcgcttttgt cctttttgct ttccggacgg tcattcagtt tagctagaaa 3465601 ttctggtttc ttccttgcca cttcctcttg agaaggtgct tctatttttt ggatttcaaa 3465661 tccgatatat tcttcaatgt cggctaaaaa ccgtttttcg aaggccgtga caaacgaaat 3465721 ggcctttcct ttgttccctg cgcgtcccgt tcggcccgtg cggtggacat agctttcttt 3465781 ttcaagcggc agatcatagt tgatgacaag ggagatattt tcaatatcaa tcccgcgcgc 3465841 ggcgacatcc gtcgccacta agtaacggta ctcgccacgt ttaaattcat tcatgacgtc 3465901 gaatcggtct tcctgaatca ttccgccgtg aattttatcg catggatatc ccaagtcatc 3465961 caattcatcg gtcagctgat tgacgtgctc cttcgttcgg cagaaaatga tgcagctgtc 3466021 gggattctcc gtcatcagca catctttcag caatgaaaac ttattctctt ctcttacttg 3466081 aatcaccgca tgttcaatat ttcttgtggt taggccggcc gctttgacct cgatatgctc 3466141 ggggttttgc atatattgac ggctcagctt ctcgatatcc tgcggaagcg tcgctgaaaa 3466201 cagcatcgtc gtacgctcag tcggcagatg cttgataatc gcctccacct gctcaatgaa 3466261 gcccatattc agcatctcat ccgcttcatc aatgaccaaa taagagagac gatccaacgg 3466321 cagcgtgcct ttttcgatat gatccagaac acgtcccggc gtgccgacaa caatgtggct 3466381 tttttgctta agctcagctt tttgtttatc aaaggaggat tttccaaata cggctgtcgc 3466441 tttgatccgt ttaaatcgtc cgatgttcgt gatatcttcc tttacttgca ccgcaagctc 3466501 acgggtcggt gttaaaataa gcgcctgcgg cttgttttca tcccaattcg ccagctcaca 3466561 gagaggaatc ccgaacgaag ccgttttccc gcttcctgtc tgtgatttga cgacaagatc 3466621 ctttcgttca agggcagcgg ggatcacact ctgctgcacc ttggtcggtt ctgtatatcc 3466681 cagtccttcc aatgctcgta aaatgtcatg actgatttga tagtttttaa aatgactcat 3466741 gtataaactc ctgtctcttg cagatgttct cattatactc taattgacca aggcatatgt 3466801 gttttgtcga aaaatgatgt attaaaagcc agcgattccc tggcgtttta gctcctgaac 3466861 agccaatcgc gccagtgcgt cggcccccgc gcgattcggg tgcagcgtat ctccatccat 3466921 ataaagcccg agtgttcttt ccggaccgat cgatgtaaag tatgccgagc tgaggacatt 3466981 taagtcaatg agatatgttt tttcctcttc ggccaaagct aaaatagagg ccctgtacca 3467041 tctgtttaca gacgaatgga tgccttcaga agtaaaatcg gttgcccggc cctgaggcgt 3467101 tgataggatg acgtccgctc ctttcgcttt tacctgacga atcatatcac gcatcacctc 3467161 tttaaactcc gcttcagatt ctttatgctt cggatttgtg tcattaatgc caagctgcaa 3467221 cataaaataa tctccgggtt taatatactt cagaatcgcc tcaagctgtc catcatttct 3467281 gaaccctctc gcgatctgcc cgccagacgc catgtttctc acttgaaagg tgtgtttatc 3467341 gatatagtga ggcagcatct gcccccagcc cgcctgcttg ctgctgttga gcggataata 3467401 attgcacacc gtcgagtcgc cgccgacata aatggttcga ttcgttaccg gctgatcaga 3467461 caatttcttt attttcaagg cgctgagcgt aaaagcggtg cctgcctttc cctctgtcac 3467521 cagcagattc agctgcccgt cggtgacggg aatttggaac gtatcctccg cgccatcccc 3467581 tgtcatattg atgacctgaa acacgccctc cgctgccaca ctggcccttg ccgtattgcc 3467641 aagcgtcacc ttcacctcat aaaggccatt cgggagatca acattaaacg tgttattgct 3467701 tttcgtccca tacgctaaaa actgaaccgc atcactcttc acaccagccc cggatgccgc 3467761 cacatccctc atattctccg gtgtttgaaa accgtagccc tttgaccggt cataccgatc 3467821 agacgccctg acaccaatat aaccaggctc catcgaaccg cttccaaagt caaactgata 3467881 caccttcggc tccgccgcct tcacattctc aatcccgcca aaacacagca tcagcatcat 3467941 cacaaaaacc gctgccatcc attttttcat caagactccc cctctatgaa aacgaataca 3468001 ttaatgcata ctcggtgatt gtttctttat gatgactgaa ttaagaaaaa aattgcgttg 3468061 aggaataaaa atgaggggag agtctcaaga aggggaaaat cagtgtgact tcttgtcaca 3468121 cttgatcaca tcccaacctc cgcaatagaa gcttatttgg ttttcttcgt catacacata 3468181 ataacggagt ctttcccatt gatcgtcagt cggtacaatc tccaatgcaa ccgaatcgat 3468241 ggattcaagg tcatccagct ttgatgcact aatgttttca aaccgcaatt gaatgtcaca 3468301 ggtttgagca gatcgttttc attcaaacac aggaatatga atataacgat catcttcttt 3468361 catatagaaa gaaaactcgt ttaatgtaaa tggacctgta tcctcatcag aaagatgctg 3468421 tttcaatttc tcgtattgtg tgatattcaa atgaattccc tctatttata tgattcaccg 3468481 ccaatcatat aaatgtccac agcatcgtat tcaaaccata tgatccgttc gcctgagtcc 3468541 gttaggcatt ggagcttccc ttctgaaaaa tagcttttat ccggttgagg atcagtgatc 3468601 agaaaaacat catcattgat ggaagctagc agaaagagaa aatctgcaat atcccggtct 3468661 gcttcctgta atatggattg gaaatggaat tcccttttgg ccagcttcgt caccttgtaa 3468721 gcatgacctt caaaatactc ggacaggtct tctataaatg aaccagtcgt tattacctgt 3468781 atcatgattc gatcgtaggc aagccctgcc caaaaacgat aaaacgactc tgcatcttca 3468841 agttcgcatg ccataacggt ttggtcaggc ttaagctcga tcatgtccaa attgccaata 3468901 ctgcttatag aggttatttc cataaaatct tccccttatc agttggatag cgcaacgcaa 3468961 atctcttgtc tgacttgttc atacaagaga atgtgatgat acagatcctt atcgtttttg 3469021 atcatatccg gaagtatgtc aggatacagc tcaaaaaagc ttttctccaa cgaacgccgc 3469081 tgatgccggg gtatcctttt attcgccagc acataatcca aactgccagc aacaagcata 3469141 aaaaactcat agatttccgc ttcaaagccg tacaattcat cagggtactg cttttcttca 3469201 agctctcgct gtctttttct cagtttttga agcacgttga tcctctccct tccgcaataa 3469261 tctcatttat ttcgaaacag aataggcgga tcattatcta tcgcctccaa cagctcttca 3469321 ccaaacacag tgattgcaca tttccacggg tctcccaaaa gtccccagga gaagtcctga 3469381 tgaaaaaaga aataatagtc tccatttgga aatacgggaa caggccattc gccaaattca 3469441 tccttaggca ttgcctgatg aggactaaag gtatatccgt catgctgcca atctagtgcg 3469501 tacattacat cgttctttcc agtacctaat tgaaatgctt ttaaaataga agtctctaaa 3469561 tcacttagca ctccgctcac atcattatga ccagctttac tgctcatcgc gcttgagata 3469621 tcaaacactc gatatggatc aggcgggatg atgtgatgac atctgcttcc gggcttccat 3469681 tttatgatct tgttcacttc tgaccagatg cggtcttgtt ttgtctgact taaagcgcgc 3469741 caattcatca taatctcatc cctacacctt attggatatc ctgcttataa acaccagaag 3469801 aggccactgc gtaaacagcg taacttgtca gtttcagctg ttgaacatct aggccttcac 3469861 cgttcgaatc acagcatgtt atctcttcca tctcttgact cacatcggca gaaatcaaat 3469921 aaagagacga cttaaggtct gcactgtaac aattgaacgt cccaaccaaa aaaccttctt 3469981 cggatatcgc gagctgatca aatgcttctg agtccggctc tttatccgac agaatccaca 3470041 cccgtctcac gaccgtttca tcaaatgcgg caatgactgc atctccgtaa tacagcatat 3470101 aaatcaagcc gtttttttct gcaagtccat aacaatcatc tacagcaggc gcatccattt 3470161 cttcaagctt tctatcaatg tgtatttcct tctgctgacc atctaacgta aaacaccaca 3470221 cactatggcc gttgggattc tcatcatgat aaatcccttc atcacataaa ccgacccaaa 3470281 gctgttgttt ctaatccaaa agacagcagg aaacccctga aggcaagtga aaaacacttt 3470341 tcacccttcc ctcttctgaa aaaaccttta ccttcggctc gtacgattcg taataaacga 3470401 agacatagcc atctgcacat tgttgaaaga gcagaatatc actgtatgaa atctgctctt 3470461 tcactctaaa atcccgaaca tcaccggaag gatcatagat tgtaatggtg ataccacctt 3470521 tcaacccttt tccaatgtag acacgcccct gtggatcagc atggaaaaaa caatcttggg 3470581 tgttctcgtt gatgatttta ttcaatttta attttttcat tggttatgct cctaggttcg 3470641 aaatgaaatg ataagaataa accatttatt agctattagt aacggacaac ctagtttcat 3470701 taatcgtttt gggataaatc tactttccaa ttcagcctta aatcatttag tgtttaattg 3470761 gtatgcataa aacgattgat catcaaagcg aactgtttca gcttctatag caatcagcat 3470821 tctgttcatg tcaataagaa agttagcatt tgattgatac tccggaatta tagaatttga 3470881 tagattcccg attccttctg gatgataact catctcaaat acttgccaat tgtattcttc 3470941 cggatctatt ttttccaatc tcatgtcgcc aacatctgca ctataataag cggatgccac 3471001 attttgaaat gaaattttat gcgtatattc accttcatct tcaaaaacct taatatcaag 3471061 tgagagttct tttttaaaca cattaaaatc taaatgaagg acactgcacc ccttatctat 3471121 ataatcaacc cattcattaa tcgtttgata cattgtcatc ccctgcctct ttttaaacaa 3471181 taacgccttg ccaccaagca gaaaacaaat tactccgtat attgtttgat ccaatcattt 3471241 aaatcatctg ttgaatgcaa ataagtttct gatgaatctt tcaaatcaat cccacttaga 3471301 aggattaaca tatcccagac tctatcgtct tctacttcgg ggtcatccgc ataaacataa 3471361 gttccagccc aatccgacac ttcttctctt gttgtttgtc catttaagac acttttgatt 3471421 ttatttatgc attctattag atttgtctcg ctcaatttga tcaccacgta ttcaagtact 3471481 aaatgatttt ttattagtat gcaaagcacc gtactgatat ttagatattg aagctttttc 3471541 cgtaaaagat atgttccaaa aggtttccaa tctaccaata aacaagctca catccgtatt 3471601 ccgtgtgcaa tatacataaa ccaaactggc acttaggctc aaccaaaata aaactatgat 3471661 tgagaatccc ttcatcgaac tcaatacact ccaataagca gtcaaggtgc tcgagacatt 3471721 ttccaaaaga acaaactaac gcaccaattt cgctgctgta ttgatgaaac agcagaacgt 3471781 cccggtcatc gtaagcaaca tatgactgag atattttcca gatcagctgt ttcgcttccg 3471841 ttttttcgag ggcatcaacc tcacgggtgt tggctggtat tgaatttgat aaaaccagct 3471901 caagcaattg cctgctttgc gccagatcag caaaacgata agtgaagcct ctttctgcac 3471961 aagggactag tttttctttg atttcgctca tcaataaacg tcttttattc tcggcgagtt 3472021 tttcgatcaa tcttttttgc atgagccgca ttccctccgc tgtcaatttc tcaacttctt 3472081 ttaaattgat tcatcattct cttgttttcg ttgtcgttca tgtttagatt tgttctaaaa 3472141 aagcttgtat cgcttatcga tacaagcttt atcttcaact gcttaaaact cacccagtgg 3472201 gcttttcaca aaacgctggg aacctttttg gcaaatcctc ttcatcccaa tcaattctat 3472261 atttttagat tcttttgtca tacaaataag agaggatggt aacatctctt atttaatgtt 3472321 ccatcaataa atgccccatt tttatccaat gcagaaatta tttataatta aggaagttta 3472381 gaaggatttt ttgtattttc aagatttaat tttaaagcgg tcacaaaaga ctctagcttt 3472441 tcttcattac aattaatttc gaacaagttg gagttcgact tactttcttt ataatcatca 3472501 aatataattt taatcttaat tctgtaattt ccgttttctt gatcaatact aagaaataag 3472561 aatggttcaa tagtctctaa actgatactg tcttgatttc cttttatcat agtttcgatc 3472621 ccagatatca acaccttata ttcactttct aataaaacag cagaaaaatc gcgaacgacg 3472681 gctttcttat tttccaacaa ttcaaataca gataaaataa atggatcatc gtccaactct 3472741 tgataccttc tcggtgttaa ttcaagttct atacaatcat cttttatttt ggccatattt 3472801 cctcctcatt taaagtttaa gtgagggtag ttgtcatccc cccctcgctt aaccttatta 3472861 acgccttctc ttagatttat ttccttttcc gtgtgtatgg aatacgtgtt tagaaccctt 3472921 agctcttgaa cttccataag ctgtgattac tttacccctt ttatttaaaa caactgtagc 3472981 tttttttcca acatatttcg ttgccccatt aggttgtttt attacttttt tagggcttcg 3473041 cacagcattc agtttggccc ttaaattgac tccacggcct ccatttcttc ctatagattg 3473101 attaagtcca tgtcttgtat gacctgtgat tttaactgcc ttcttcgtaa acttataggc 3473161 gcgactagca cccttaaata tcttcccagg accaaaatta gaagcagctg cccaagcagc 3473221 acctttccat cctttacctg atttatatgc cttatatcca tcataggctg caaatccggc 3473281 atttaccaca agccataccc aatgcccgtc cggatcaaca ttcatcactg ggttattatt 3473341 tccataagca tacccattct gatccaatga atctccgtcg ctgcccgggt ctgggtcgag 3473401 cgataggaac acgccgtttc ttggctcgta gtagcgggcc atgagatagt acaggccggt 3473461 ttcttcgtcg tattggtagc ctgcgtagcg gtagcgattg tcttttactt cgtcgcttgc 3473521 ttcggttttt gttggatttc cccatgcgtc gtattgatac ttggcaacgg tttttccagt 3473581 gctgtctgag atcgcgatga tgtcgccgtg agcgttgtag tgatagaaat atttcttacc 3473641 attttctgtg taggataaca gctggccgct gtctccgtac gtgtatgatt ttgtgacgtt 3473701 gttgtccgcg tctgtttcat acaagacgtt caagctgtct ccgtcgtaga agtagttcgt 3473761 gacttttccg ttgacggttt tttggattct gtttcctttt tcgtcatact tatatgttgc 3473821 gaatggcttg tcttcgcctt ttttggtaac ggcggtcagg ttatcttctg catcccacgt 3473881 atatgtgaat ttgccgtcgg atgtgcggtt gccgttttta tcgtaagaga tgctttcatc 3473941 attgactttt gtcagctggt tcatgatgtt gaaggaagcg ttcaccgttt tgcttgagcc 3474001 gtcttttata gttgtaacgg ttttccggtt tccgaatcca tcatatgtgt attcaataac 3474061 agtaccgtct tcatgggttt ctttgacaag ctgattcagc ttcccatact catattgcac 3474121 cttgccgctt gctgagctgt ttatcgttgt gcggttgccg ttggcatcat attcatagct 3474181 ttccgtcaga atgtctccgc cgtttttgtc accgatatgc agcgagctta caaggtttct 3474241 ttcgtcatat gaaaaacttg ttccgccgcc gttgcccgta ataaaggttt ggacgtttcc 3474301 attttcatca taatcaaatg aatatgagga tgtactgtct ttcatctcaa tcatttgatc 3474361 cagcttgtta tacgtaaatt gattcgttcc tttttggtcc ccatgaatcc acgagaaggt 3474421 tttcagctta tcggagtcac taggatatgt ccaagtttgg ctgccgccgc ggtctgtcag 3474481 ttcggttaaa cggtttttgt tgtcaaatgt ccgtttcttt gtggtgttct gctctttatt 3474541 gacgaccgac gtttcatttc catttttgtc atacgtgaaa atgtactttt ctgtaccgtt 3474601 atacgacttt gatttcaccc ggtctgttcc atcataagaa agagacactt cgttgccatt 3474661 tggtgaaatg gttttggtca ggttgctgtt ggcatcatat tcgcttgcta acacattgcc 3474721 gagagggtca gttgttttga caagcttgcc catgacatca tattcgaatt tataggtttg 3474781 atctgctcct gcccggatgg ttttgcttac ctcattgcct tccttatcat agctgtgaag 3474841 gatagacgtg ccgttagaga gcgtcatgtt tgtcaattgg tctgcctgat catacgtata 3474901 ggttgttttt tcaccttttg catctgtttc agacgttttc ttaccagttt catcgtaatc 3474961 agttgaagtg gcgtaaccta gttcgtcctc ttccttggtc acatagttgc cattactgtc 3475021 atacgtgctt ttagtcagaa ggcttccttc aatcaaacgg atatcatcaa accagactgt 3475081 gcctgtcgca ctcttttgga acagaatact gatatcgact ttattgatcg gctttgtttt 3475141 agggatgacg acagctgctc ggttccattc ctgtgttcca gaagggaatt tcgcattgta 3475201 gatgcctgtg ctgccgtcag cgtaagtgac attcgcctgc agagaatagt ctttttcatc 3475261 tgtaaatttg acgctgcttg ctttcgacat tcctgtcagt gtgagataaa ccggtttgtc 3475321 atttgcgctt tgccctaaga caacggtttg ttttgttact gatccggctt gggacgcact 3475381 ggtccgggca gcttttaatg atacatcatc attaaagcct tcttcagaat caacggatgc 3475441 tccgcttaca ttccagtttt ccgttgctga tgtgaagctg ctgttttgaa ctgggttata 3475501 gcttgatgat acttcgcctt tttccagctg gacttcatca aaccatgctt ttcctttgcc 3475561 atctttatct ttatgatcga cttccatata cacaacagct ttgcctgcat tcgctggagt 3475621 cgtaaaagtg atttgccgtt ttgtccagtc attttttccg gctaatgcac tgtattcatt 3475681 gtgaatccat tgaattcgtt tttgatcttt gtctcgcaaa tcaatgttaa aataggctct 3475741 tgatttcgca agatctgttt tgattttccc gcttaatgta taggttgtat tcggctccag 3475801 ctcaactgtt tgtgttgctg acgaataccc atgatctgtt ccggcagacg ttgattggct 3475861 caagacctcc aatgcctttg atccggaaag aactccgctt ttatcggcga tgactgaaat 3475921 tttgccgctg tctttagagg cagtcagatt ccagccggat ttttgagctt caaagcttcc 3475981 atctttcaaa atattagttg aagctgataa atctttgctc gattgaatct ggtttccata 3476041 tttatcataa acagctgctg acgatgattt tccgctctga tcggtttcgg atacagcatc 3476101 cagtccgtca taagcaatat ccgtgacatt gccctcggta tccttcatct ttgtgacatc 3476161 gttgtttttg ttgtattcgt atgtctcagt tccatatgca tctttaaccg acgtaacgtt 3476221 gccatctttg tcatattgat agctttccgt tgcttttccg gtgccgacgt catttggatc 3476281 tacatcttct acaacattgt tgccttcata ctttgtattc gttgtaattt ttaacccttc 3476341 cgcatcatca atgacctgaa tcggatttcc cgcttcatta tagccatact gtactttccg 3476401 gccatttggc tgtgtcatga gaagcgtctt tttatcagca tcatagctgt agacatatgt 3476461 ttctttttta gcgttgatcg ctttttcgag acggtgaccg ctatactgat attcggtaaa 3476521 gacaggcttt gcttcggtac tgttagctga atattgtttg acaaggcgcc cttcactatc 3476581 gtagtcatag cttgtgacag tcccgtctgt atctgtaacc ttcttcagca aatcattctc 3476641 atatgagtag gtgactttct tattcttagg tcctgtgatg gacgtcacat ggccgttttc 3476701 atcataggta aatgtaagct tgcggcctga tgcatctgta atggcggtca gttgattttt 3476761 gtcattgtaa gtatagacag ttgcattgtt atggccatcc actacctttt ggagtttgcc 3476821 gcctttttta ttgaaataag cgttggtttg atcctttgtt tttaatatga actgatcagc 3476881 tgtttctgtt aattcaagat atacaccggt cggcggctga tacgtgccat cggctttttt 3476941 cgtgaatcga tgtgtcgtag cgtcttcatc gatatacatt gccccgccat ccgttgagat 3477001 gacagatgtt tctgcatcag cataccagcc ttgtccaaat aagtgatcag agctgtcaag 3477061 actgttgtag gttctcgata agccaagtcc cggaccgcgt ccatcaattg acaaatcttc 3477121 ttcattcaca atgacattgc ctgtcgcacc atttaactgg ccgcttggga tatcaatgat 3477181 agaccagtac tcttctgtac ctaggaattc tgcgccttca tggaacgttg ggttaaaggg 3477241 cgccgttgga atcgtttcac cattcgcatc ataggcgaca agcgtgaaag aataattctt 3477301 cttccctttg taattcccat ttgcattgtt atagacaggt gatggatcga gggctaattc 3477361 cccgcctttt ccatctgtat gaagcttata gcttccggct ttgatttcct cagaagtcgg 3477421 ccagatgttt ttattttggg ttgtccaatg atcagcatca ccaacatcaa aggactgata 3477481 ttctttaccg ttgtaaatgt taactttata gcccttcgca ttttgaacct tttcccatat 3477541 caaattcaca taacccgttt gactcgattt tgtatttgta tacaaatagc cagttacatt 3477601 ctttggccta gcgatatcag gaagtgccgg ggtagcagcc ggggatgcaa tggcttcgcc 3477661 gtctttgttg tatgcgataa ttttaaacga gtaatttctt ttggctccat ctcccccggc 3477721 gtttttatag gttggtccgg gattgatcgg cagctctgct ccgcttccgt cctttaggtg 3477781 aagagcatat tttcccgcct tgatttctgc acttgtcggc cagatctttt tcccttttgt 3477841 ggtccaagac gtctgatttc cgagatcaag tgtctcaaag cctttcccat tgaacacctg 3477901 aaccttatag ccggttgcac cggatacagc tttccaagaa aggtcgaagt atcctgtggc 3477961 attcccatta ttgtagccct ttgctgacgg tgcttgtgct tttcctacat tagggataac 3478021 gggctttgcc ggtgcggaca tcgctccttc accttggtca aatatcgcac tgacgccaat 3478081 ccaatagttt ttgcttgtag catagcttcc gccggaattc ttatagaccg gggatggatc 3478141 taatgccaat tcagctccat ccttgccgtc cagatgcagt ttatatctct tggaggcaat 3478201 ttctgcgctc gtaggccaga tttttttacc ttttgtgctc cacgacgtga cgttgcctgc 3478261 agaaatcgct tgatattcct taccattgta aatccatacc ttatatcctt ttgcgccttc 3478321 aacctttttc cagctgatat cgaaataacc agtggaatcg ccgttgtgat aggctttgat 3478381 tgtaggtgtg tttccctttg gaatggtata cgtcacttca atatatggtt tattggcgga 3478441 gttcgctgaa gaaattagtt ttttccaata ttccttgccg tttccgtttg tatgaagctt 3478501 aaatccatag ttggccccgc cggagttcca tgactttaca gcagcggtca catcataact 3478561 cgcccactgt cctttatgga cgtcggcttt tccgatattt ttagatgccg gtttggtgtt 3478621 ccatgtcact tttgcattat cataattgct gttgaccgta tccagccaaa ggccggttgc 3478681 ctttgttcca taataggaat gggctacgta tgtttttaat gtagctttag tgacagtcat 3478741 attttgaatt ggctttaggt tgttaaattt catgaacgca tagtttgtgc ctgttgtttt 3478801 gtcataatag cccgttttca gtacataggc ctttaaatta gcatcccatt tttgtgagga 3478861 ggccgaatag ttcgtcgtcg ggtaggcact catgacaaac gtatccgatg aaacagataa 3478921 agaagttgac gggtcgatag atactggata tacgcgttct gggtctttca gccagttctc 3478981 gtctgccgta agatgaagca aatacccttc ttcattcttt tccagcttat agctgacttt 3479041 gtctgaccgt tcaacctcgc cggaaagctc atctagtttt gaatccgtca taaaaggctt 3479101 aggcacagaa aaaacaactt ttcctttttc atcagaaaaa tcaatggatc catcctcttg 3479161 ttctttagcc tgcaaatcgg tttttaactg aaatgtaaat gtgttgtatc cattatactg 3479221 atgaaggact aaatcttctt ttatgttttc attgaatgtg aaagtctgaa gatcaatatt 3479281 cggaaacaca tccggataca caatctcatt actgtcagtc ttataatctg ctgaggtatc 3479341 tttcggagta agtgaagttt tattcgggcc tttcgcttct gctagtgaat atgtaacctt 3479401 atggtcatta tgctcaaaag tcgcataaag cccgttcttc atttgctttt gaaaatctga 3479461 attcaaaata gcgttctctg tctcgacttg tttgcttgtc gactctttta actcaggaga 3479521 aatgtcttcc cagtcggcat ccggtgtttc ctttgtatga ataggatcaa ggtatacttc 3479581 ctgtttatag acaccgtcac cttcataata gagttttgta ttttctgttc tttcagaggt 3479641 gatctcaccc tctttgttta tatcttttgg atcaaaaggt acagcttcct cagtttgttc 3479701 tttctgaaga gtttcttctg gatcatcggc agcaatacgg tttccattct cttcttctgt 3479761 agattttgct agtacatcgg ctggcactaa tgaaatcatt aaagccaaca ctaaaaatgc 3479821 tgcaatgaac cttttaaagt ttcgcctctt tctttttttc atttcctctc tccttttgta 3479881 ataaaagtaa tatttactca ataatcttaa ctagactgaa atatcattac aatatttttc 3479941 tagaaaattt atcttatttt aaggattagc gagagtcaat tgacctaaaa caaaaaaagg 3480001 ccgcataggc ctttttacat tttttattgt atttgttcaa tatccgtacc ctcagctgtc 3480061 acattcgcct tcccctgcct cctgacaagc gtcaaggcca tgcccgcaaa gatcattacg 3480121 atgccaagcg tttgatagag gtcagggcgg aagcctgtga agacggtatc gagcacgatc 3480181 gcgacagcgg ggtcgagaaa tacaatgatt gaaataaatt tcgttgataa aaatcgtaaa 3480241 ctgtcaaaaa acagcaaata tacaataccc gtatggatga tgccggtaga taccaccata 3480301 atccagtttc cctgagatag gtccgcaaaa gcgccaaagt gaataaacgg aatcaggatg 3480361 ataaccccta aacctgtctg caagaaggtg gtcgtgtaag gactgagatt gtgaatgcct 3480421 tttcccaata aagtggtgaa cgcataaaac agtgcggcga gaactgccca tatgatccct 3480481 gatcccatca gctgtgtcaa tgatgtgctg ccgttaatcc cggaaatcag cgcagtccca 3480541 agaaagcaga tgataatgga gctgacggag atcacattta atttctctct gtagaagaag 3480601 ctccccagaa gaagaacaag caccggcgct agatgataaa cagagatggc aattgtaacg 3480661 gacgtttctt caaaagactt aaataagaac acccagttga atacaagaaa gaaaccgcac 3480721 gccaatgttt gcagcacgtc tctcttgctc catttttcag ttttatactg gccggacgcc 3480781 agccagcaaa agcctaaaaa cagcgtcgcg caaaggcagc ggacaaagac caattcaaat 3480841 gacggcagat tggtatgctc tgagaaaaag ccgatggagc cgaaaatcac catagagatg 3480901 accattttga ttacggctgt tgatttttgt tttgacgata tggaaggatc ctgttgcatc 3480961 aaacgtattc tacctccaat actgcatagc ataaactgtt ttttgtgaat tcagaaatct 3481021 acacatagaa ttcctctttt ttacatgtag atattataac acttctattc taaataaaaa 3481081 aaagcgccca agggcgcttt ttttacaaat ctatcgaaca atcaaaaccg ggcatgttga 3481141 taattgagac actttatggc tgacgcttcc aagcatcatt tctttcaggc cgctgatccc 3481201 ccggctgcca actacaatca ggctgacgcc tttctctttt gcgtgattta gtatctcatg 3481261 cgccggctcg ccattcgcgt aaatggtttc agcttgaacg cctttttcgg ctgctttttc 3481321 ttttgcattc tcaaggattt tcaggccctc ttttttaacc tcgttcctga tttcatcaat 3481381 aaagtgttca ggcacataga caattcccgt cagagaagaa gtcgtgacga cggcttctct 3481441 ccccacatga agaatgctta gttccgcttg ttgctctttt gccaaatgca ctgcggcatc 3481501 aagcgctttt gcactcatgt ctgatccgtc aatcgctact aacattttgt taaacatgct 3481561 cttcccgcct ttcggactgt gggtggttca tctttctctt ttattgtccg cctgcatttc 3481621 gttattgtca attgaagcgc atgagttttc aaaaaattgt cagagactct ctccgtttgt 3481681 ggcgataacc tgctgatacc agttgaagct ttttttcttg atgcggttaa atgttccatt 3481741 tccttcattg tcccggtcta cataaatgaa gccgtagcgc tttttcattt ccgcagtaga 3481801 tgcgctgaca aggtcaattg gcccccatga tgtgtatccg attaattcaa cgccgtccgc 3481861 aatggcttcg cgcgcttcaa ttaaatgatc acgcagatag ttgattctgt aatcgtcctg 3481921 aatcgtgccg tcctcttcaa ccttgtctac agcgccaagg ccgttttcaa cgatgaacag 3481981 cggcttctgg taacggtcgt ataaggtgtt gagcgtgatg cgcaagcctt tcggatcaat 3482041 ctgccagccc cattctgatg atttgaggta agggtttttg actccgccca gcaggttgcc 3482101 ccctgatttt gcaagctctt ccggatctgt gctcgccgcc atcgacatgt agtagctaaa 3482161 tccaatataa tccaccgtat gttctttcaa gagctcttca tcgccttcag ccatttcaat 3482221 ttcaatattg ttttctgcca gatagcgttt catatatccc gggtatgcgc ctcttgcctg 3482281 aacatctgag aagaaaagtg ttttgcgctc attctccatt gccgcgaaga catcctccgg 3482341 cttagaagtc atcggatagg ttgtcgttgc cgctatcata cagccgattt tcgaatcagg 3482401 aatgatgtcg tgacccgctt tgacagcaag agcactggcc acaaattggt ggtgtgccgc 3482461 ctggtacatc gcgtttaatt tgttttctcc ttcttcaaaa acaagaccgc ctccggtaaa 3482521 tggcgcatgg agcactacgt taatttcatt aaacgtcatc caatacttca ctttgtgttg 3482581 atagcgtttg aaaaccgttt tggcatagcg ttcataaaac tctatgactt tgcgattctt 3482641 ccagccgcca taatttttca ctaaaccgag cggcatctca taatgagaga tggttacgac 3482701 aggctcaata tgatgcttta acagctcatc aaacagatca tcataaaatc tgaggccttc 3482761 ttcattgggc tcctcttcat cgccattcgg aaaaattctc gtccacgcaa tcgatgtgcg 3482821 gaacgcctta aatcccattt ctgcaaataa ggcgatatcc tctttataac gatgataaaa 3482881 gtcaatcccg ttgtgataca gattcaagga agtcattgat tcatcaaatg gagacatgat 3482941 cccgttcggc gatacgtcag ctgtcgaaag ccccttacca ccctcgttat aagcaccctc 3483001 cacttggttg gcagcaactg cgccgcccca taaaaatcct tctggaaatc gtttttcatt 3483061 tgaactcata ttgatcaccc cattagtttt ttcaagataa agcaagcagc gcttcttttg 3483121 gctgcacttt accgatctct ttcaccggcg aaaacgaata ttggtctgtg ttggtcacaa 3483181 tcaccggggt aatgacgtca tatcccgcgg ctttgatttg ctccagatca aaggacacga 3483241 gcggatctcc cggtgcgacc ttgtcgcctt ctttgatgtg agccgtgaac cattgtccct 3483301 ccagctttac cgtgtccaat ccaatgtgta tgagtatttc agctccctga tcactcgtaa 3483361 tgccaattgc gtgttttgtt ttaaaaatgg tggtaacgct tccacgaaca ggcgaaacaa 3483421 cttctccttc ttcaggctca atggcaaatc cttttcccat gaccccagca gaaaacactc 3483481 cgtctttgac ttcacttaag gctttcactt ctcccttaat cgggctgtga atgatctctc 3483541 tgctgccttc atgcactgcc ggctgctggc tgccgtcaga aggcacatcc tcgaatccaa 3483601 gcaaatacgc agctgctgtt cccgccgcaa acgcaatcac aaggccgatc atcgcgtaaa 3483661 taaacgttgg gccgataaag acagggatgc tcggcagacc tgcattcccc ccgacgatat 3483721 aggaagcaac acccgtcatg ccgtaaaacg cgccaccggc tgcaccgcca atcaaagcgg 3483781 ccgcaaacgg ctttttcaat cgcatattca cgccgtacat cgcaggttct gtgatcccca 3483841 tcagcgccgt gatgcttgtg gtaagcgcga gtgatttaaa ttttttgttt ctagagcgaa 3483901 ggaagacggc aaatgatgct cccgcctgcc ccatattcgc caaaaacata gccggcagta 3483961 aataatcgtg gccgttttga gcgatgttgt tgatcatgat cggcacaaag gcatagtgca 3484021 tgcccgtcat aatgattaaa gagaatgtac ccgccagcaa aatcattgcc acaagccctg 3484081 catgatcaaa caaataattg accccagaag acaagtattc tcctaaaata gcgccaagcg 3484141 gaccgactgt aatcaatgtc agcggcacga caatcaatag cgtgaatgtc ggaaccacaa 3484201 tcaatttgag agatgcgtgt gtaaaacggt caatccattt ttccacgtat gaagcaatcc 3484261 aaatcgacag caaaatcggg atgaccgttg acgaataagt ggcagcggtt acaggaagcc 3484321 cgataaagga aatcggtttc cccgcaccga gcagggctgt caaatccgga tgcaggatcg 3484381 ccgccgcaat ggcagccgct acgtacggat tgcttccgaa ttttctcgcc gcactcatcg 3484441 ctagcaggag cggcaggaag tagaacgcac cgtcaccgac agccgtcaaa atgacatgaa 3484501 cctggctctt ctccgccatc cagccaaacg tgactgccag cgccacaagt cctttgatca 3484561 tccccgctcc cgcaatcgca ggcagaatag gggtaaacac cccagaaatc acatcaaaga 3484621 ccgcactcag cacattcttt ttctgagagg atgaaccagc gctcttttca tcactgagat 3484681 tgctgtgccg cacaatcgcc tgatacacct tcggcacatc gtttccgata atgatttgaa 3484741 actgctcgcc gctgatattg gtgcccatca ctccaggcag ctgctccagc tgactgcgat 3484801 ccgccttcgc gttgtcatga agattaaaac gcagcctcgt catgcagtgg atcacgcgct 3484861 gaacgttttc ttcaccgcct acgagttgta atatgtcctt cgataattta tcataatcca 3484921 tgtgtatacc tcctttttat ggggggactg ctggatgaaa ggtggccgcc tttcaccagc 3484981 tttttttgta tcaaatgctg catcacctcc taaaagagaa taaaaaaacc taaatgacac 3485041 agattgcgag agtctcctcc tgcacctgca ccatttaggt tttgcctgct ttcgcagtaa 3485101 caatcctgac gggtcgtttt atttgtttgt aggtatactt tagcactaga ttcgtgagat 3485161 gtcaacgctt tcatttttgg tgttgactat cgtttctaga acaaaagtaa tcataaagat 3485221 ttgaacttag tattaacttc aataaaaaat tattgtaatt aaaaaccttg aaaggcattt 3485281 tttccaatca aggttatgaa tcgttaccgt ttaaattttt ttaaagactt ctttatctgt 3485341 actattacat tctttagcca atctattggt tctaaattaa acgcaggaag atacacgcca 3485401 tctgcgcaag attgaatgta atcgtttttc ttattgtctg aatgctcact ttcaataaaa 3485461 tccgttaaaa agacaatagc atcctccaaa tattccttac tttcctctat taataactct 3485521 tgtatagcgt catcaggagt ttcaatatct tgatggaatg ttccagctaa aaactgaaaa 3485581 acagggtcct tctgtttatt gatcaataac atgtcatctt gctcctttaa gggagaggta 3485641 acgggataat gttaaaatca ttcatcatct aataaatcaa gataatactg atcattctct 3485701 tctatttttc ttaagaactc ggtaagagaa gttgcaattt gaatatcata atagtaaatc 3485761 ggatttttat tattatcatt taattcaatt gacattaatg ccgattcact accttcaaaa 3485821 aatattaatt tatcattctc aaactcatca tatatttcta tgtcaggata aaattcaaag 3485881 tcatttatcc tcaatcgaaa gtctcttaca gaatatggat ccaaaatgcg attagtatta 3485941 aactctgatc ctttaataaa cccatagcca acttctaaat aaaaattcac taattcacta 3486001 ggtaatttta agtttaaatt tttttcaacc tcttcaatct cactttgatt cactggataa 3486061 aaatcatttt ctttgtttga ttttataaaa ttataactca tttttttttg cctcctttaa 3486121 ataattcatt tgctggtgag cctgtaccat gaatcccagc ttgatgctcg ttaggaaatt 3486181 ttgctggatg catattccac cattcatgtt ctccgccaaa agtattttca attatatggt 3486241 gagcatcata cttatcccct ttttttctaa taattttacc tgttttttca gatacaacat 3486301 tttccttata aacaggccat ttttgtccag tgttttcttc ccattctttt ataactttat 3486361 tttttacttt atcaaattta gtcctgtgtt ttgcagtctc tattggtgac atttttttat 3486421 attctttatt tcttaatgct tcctttaatt tatctatttg atttttaggt aattctctac 3486481 ctgtgcgttg ttctatatct ctagcatact tttttattaa atcagaatta attttattag 3486541 cagatccact tacatcattc gcaattttcc ctttatcctt agcaacgttt ttaacttccg 3486601 aagccttctt agcctttttc ccattattaa taagtttatt aatatctatt aacttttcta 3486661 acttagctat tttggcaaat ggtactgagt ttatggaggc aacaacacgg tctttccctg 3486721 tgactttttc gcctgatacc ggatctctgc ccgtggctgc tttaaataga tcatacacgc 3486781 cggtaagttc tacagccgtc tctaaaattt tcacatatcc attctcatcc actttaatgt 3486841 ccgaaagcga gacgacaggt tcaagcttca tgtcattacc agatatgtat acattgtaaa 3486901 gtgtatcatt ataaacgact tgcttaacct ctgcatttga gaaatcagtt tttatatgtt 3486961 ctctatgttc actcgtatta tacactttac cattgataac gatgatattt ttacttacct 3487021 ttttagaatc acccgttttg acaactgaat ccactttaga cttttcattc tcggctaatt 3487081 tcttcagcat catctccatc ggtgaatcat ccgcctgctt catttgcggg ttaatcgcgc 3487141 cgaagatttg gttgatgttt tcttcttcct gtgatttcag gatggagccg cttttgtagc 3487201 ctgtgatttc aattttcggg ccggtgtaca tggtttcgag ctgatcaatg tattttttca 3487261 tcgtttgaaa atctgatttt gcggcttcta gtgcttgggt ttgctggccg tcaaattgaa 3487321 agagcttatt cagggtgtct gaaatcagcc gctcagcctg ttctgtttcc atccgaaaaa 3487381 aggaatcatt gactgtcggc aggctgacga tgtgatctat ggctgatgtc tggcgattga 3487441 ctgcgtcagt gagctgctct gtcacttctc gtgcatgctt gaccccatgt ctcgcatcgt 3487501 gtgagagaaa agcctctgcg atcatgccgt gggagttaga ttctacagag gaaatcgcat 3487561 gctgtgtttg tttcagcact tttttgtatt cgtcgataaa tatgccaaag aaaaggagaa 3487621 aaggcttgtg gcactcctcg taaaaggtcc ggatggcatc tccgcctttt cctttcagcg 3487681 catccttcat gcctgccaga tgctcaacgc ttttttccag cttctccagc tgttgttttt 3487741 gcttgtccag tttctcaatc gtatgctgaa tgccctcgtg aagagcgtgg acatctaatg 3487801 ttttcaatcc cttgtcctcc cgcgctttat ttcatggaag atgatatgtt ttcgtccgtt 3487861 tccttcatgg cgtttaccgc gctttccgtt tgtgcgatat gcttggccag aacagacgca 3487921 tatgcttcag tgagctcttt gatgtcctta tttaattgct cgatggactt cacaacattc 3487981 aaatggtttc tgcctgagag atgaccgggc aatgaggact tgagttcagc tgaattcttg 3488041 agctgagaaa gcccttgctt cactgtgtca tacaccattt taatttcctg tgccatttgt 3488101 gctcacctca ctttttatgt ttttccttct ctatttcatg ctctatcctc gtgatttggc 3488161 gtcttataga atacacatcg ccctctaatg agtggatttt tccttctatg ctttcgatga 3488221 ttccgctgac ttgatcgctt ttgatttgct gatatgcttt gttcattcct tcacgaatat 3488281 cttcaaaccg ctcagcatgt gttcctctcc atgcctcccg gttaagatga ggccggtgaa 3488341 tgagatgctg ggcctcagag aaatcgtgtt tgatttgcct aatttcgtgc agcactcgtt 3488401 ttaattgatg gatctgttcc tgcttttcat gtaagtcggc ttttaccgaa tgtaacaaca 3488461 tttcactatg catgccgcaa cacctcgtgt ttctatcaaa ctgtgtaaat tctttacaat 3488521 acagactatt ttcatattac atgatgggtc atattggata aataggtaaa aaggattgtc 3488581 ttgagaggta tagaactggt tctaaattgc taaaaatacg atctcatcac cctatgaaag 3488641 gagaaaacaa tcatagtagg gactttttat ttaagccttt aatctctcct ccagttctaa 3488701 tttttcctcc cacttaactg tttcttatag tcaataaagc tcataaaaaa acaccttccc 3488761 tcgaaggcgc ttctccatct tatttagatc cccatacagc ctcaccgctg gtattcagca 3488821 cactaaacgt catgacgttc ttctctctca ccgaatccca ctggcgtaaa aataccccgt 3488881 tatacttctt gcctgctaac gtgatgtcgg cggtgttttt tccggttttc ctccatgttc 3488941 cggtcatttc cccggaaatg gtgtggtttt tgttgagctg gatgttgatg gtttgtttga 3489001 tgtcggctga gatgtctttt ccgtgctgga taagtttgta tgttcctgtg atgtcttttt 3489061 gttttacttc tttcaatgtt tcgcccgcat aacgatatgg tgctgctacc ggccagccgt 3489121 ctttgttcat gaacaattgg tggactctga cttcgtgttc ttcacccctg cccgggaagc 3489181 gggtgtggaa gattaaatag gaacgcccgg ttttttcatc atagtatgcg gagttgtggc 3489241 ctggtgagac gtacccggtg cctttttcat tttctgtttc aaaagtgtag ctgcccatga 3489301 gtttgacgcc gtatggttcg atggaacggt cgtcgaagaa tgtgcctccc ttgccgcgga 3489361 cgtcgagcat tggattgcct tctgcatcat agtaagggcc gtccggtttc ttggagcggg 3489421 ccacacggat gttgtagccg cctgttgcat cgagaccgcc atatgatagg tataagtagt 3489481 agtattgggt gtctggattg tagagaacat acgggccttc gattctgctg tggttgccgc 3489541 cgagcagttt tttcccatat ccctgtccag gaagcgggaa gcccgttttc ggattcattt 3489601 caagtatgaa aatgccgcct gagtatgatc cgtacaccat ccacagcttg ccgtctttat 3489661 caaagaaggt atgcgggtcg acgacattcg gatgtttggt tgcatcatac ggtgttccat 3489721 cgctgcttgt gccttccatt cctgatttca aaaagatgcc tttgtttttg tatgggcctt 3489781 cgatgttgtc agcaacggca acacccatgg cggatcttgg cgaatcgccg cggcaggcgt 3489841 tgtagtacat gtagtatttg ccgtccgcca gctgcgtgac gtcagccgcc caaagagtat 3489901 cggattgcgc ccattcgaag gtttctttta attcttcata gacattcggg ataagtgggt 3489961 tgtcattgct tacgctggtg gtcagctgct gccattgcat gaggtcattc gatttagctg 3490021 aagcgagatg agatccaaaa acataaaaag tgccgtttgt ttcaatgatg gaagggtcat 3490081 ggacgctgac ttctttaaat ataggttttt gtgcatagac ggagtttggg agggtgaagg 3490141 ccatgataag agctgcaaga aaacatacac ggaacaatcg gttgaacatc taaacaattc 3490201 gcctctcttt tttattaaat tttaaacgct tacatttctc tatgaagata ccccggccta 3490261 ttaaaacagc cgaatgtttt catattcatc cagataggtg atttctcact tcacttacat 3490321 agtcagactg atgtctgtct gttttgcgca gaacttgttg cttgcatatc ctctccttca 3490381 tagttcaact cttttgctgt ttctccttct tgcatcacgt ctgtttttct ttcgcgtaca 3490441 tgtaataact gctttgtcag gttttgcatc aactgtgata cagccatttc gttgtcggcg 3490501 ttttttaaga tgatgcctga ttgcccgtca acaccagagt cattcggctg gctctttata 3490561 aaacgccttg cgaaaaatac gacttagtaa acgcatattg agagttagac agcggcgctt 3490621 gcctccttgt ctggatatcg tgtgcaatcg ctgaaaaaac ctgttctgct ttctgcgtca 3490681 cgctattaca atagcaatct aacttgttaa agactataaa aaaacctttt gacttctgct 3490741 gctgaaccaa ttaatataat actcagttaa tagttatcag aatttttagg aattgagtga 3490801 ttcatatgac actgcataaa gagcgtcgga tcggccggct gtctgttctc ctgctgctga 3490861 atgaggcgga agaaagtacg caggttgagg agctggagcg agacggatgg aaggtctgtc 3490921 ttggcaaggt aggatcaatg gacgcacata aagtagtagc cgcaattgaa accgcttcca 3490981 aaaagagcgg tgtcattcaa tctgagggtt atcgggagtc acatgcgctt tatcatgcga 3491041 cgatggaggc tttgcatggc gtgaccagag gtgaaatgct gctgggatcg ctgcttcgga 3491101 cggtgggatt gaggtttgcc gttttgaggg gaaatcctta tgaaagtgaa gcggaaggcg 3491161 attggatcgc tgtctcgctt tacggaacaa tcggggcgcc gattaaaggt cttgagcatg 3491221 aaacattcgg cgttggaatt aatcacatat gaaacagccc atagatctta gacgataggg 3491281 ggctatgcgt gaaaacagaa gttcacagca tagctccttt ttgtatgggc gctttaccaa 3491341 agtaaagaaa aaggagttgg gcttatggtg actttagacg gttcttcatt gacaacagcc 3491401 gacgtcgctc gtgtgctgtt tgattttgag gaggcagcgg cttctgagga aagtatggag 3491461 cgcgtgaaaa aaagcagagc agcagtggaa cggattgtac gcgacgaaaa gacaatctac 3491521 ggcatcaaca ccggatttgg caaattcagc gatgtcctga ttcagaaaga agactcggcg 3491581 gcgctgcagc tgaatttaat cctttctcat gcctgcggag tcggcgaccc ttttcctgag 3491641 tgtgtttcca gggcaatgct gcttttgcgc gccaatgcgc tgttaaaagg cttttccggt 3491701 gtacgcgctg agctgatcga gcagttgctt gcttttttaa ataaacgcgt ccatcctgtc 3491761 atccctcagc aaggatcact tggcgcaagc ggagatctgg cgccgctttc ccacttggcg 3491821 cttgcgctga tcggacaagg agaagtcttt tttgaggggg aaagaatgcc ggcaatgaca 3491881 ggcttgaaaa aagcaggtat tcaaccggta acgctgacat ccaaggaagg gcttgccttg 3491941 attaacggga ctcaggccat gactgcaatg ggggtggtcg cctacatcga agctgagaaa 3492001 ctagcctatc aaacagaacg aattgccagc ttaacgattg aggggttgca gggaattatc 3492061 gatgcatttg acgaggatat tcacttagcc cgcggctatc aggagcagat cgatgtcgca 3492121 gaacgaattc gcttttatct atctgacagc ggcctgacaa cctcccaggg agaactgcgg 3492181 gtacaggatg cctattcatt gcgctgtatt ccgcaagtac acggtgcgac ttggcagaca 3492241 ctaggatatg tcaaagaaaa attagagatt gaaatgaacg cagctacaga caatccactc 3492301 attttcaatg acggtgacaa agtgatttcc ggcggaaact ttcacggaca gccaatcgcc 3492361 tttgccatgg attttctgaa aatcgcaata tcagagcttg cgaatatcgc agagcgtagg 3492421 atcgaacgac ttgtgaatcc gcagctgaat gacctgccgc cgttcctgag ccctcatccc 3492481 ggtctgcaat ccggtgcaat gatcatgcag tacgccgcgg cctcactcgt ttctgaaaat 3492541 aaaacactgg cccatcctgc aagtgtggat tccattccgt catccgccaa ccaagaggac 3492601 catgtcagca tgggaaccat cgccgctcgg catgcttatc aggtgatcgc aaatacaagg 3492661 agagtcattg cgatcgaagc catttgcgca ttgcaggctg ttgaatacag aggcatagaa 3492721 catgcagcgt cctatacgaa acagcttttt caagaaatga gaaaagtcgt gccgtccatt 3492781 cagcaggacc gtgttttttc ctatgacatt gaacgcttga ctgactggct gaagaaagaa 3492841 tctttaatac ctgatcatca gaataaagaa ctaaggggga tgaacatatg actgatgtaa 3492901 aaaaatcaat ccgtgccaac agaggaacag agcttgaatg cttaggatgg gagcaagagg 3492961 cagtgcttcg gatgcttcga aacaaccttg atccagaagt cgccgagaag ccggaggacc 3493021 tcatcgtata tggcgggatt ggcaaagccg cacgggattg ggacgctttt cacgccattg 3493081 agcattcctt gaaaacatta aaaaatgatg aaacattgct cgtgcaatcc ggaaagcccg 3493141 ttggcatgtt ccgtacacac ccgcaggccc ctcgcgtgct cctagcaaat tctgttcttg 3493201 ttccgaagtg ggcagactgg gagcatttcc acgaacttga gaaaaaaggg ttaatgatgt 3493261 acggacagat gacggctggc agctggattt acattggctc acaaggcata ttgcaaggaa 3493321 cctatgaaac cttcgctgag ctggcgcgac agcacttcgg gggcagctta aaaggaacgt 3493381 tgacgctgac agcgggtctc ggcggaatgg gaggcgccca gccgctgtca gtcacgatga 3493441 atgaaggcgt cgtgattgcc gtcgaggttg acgagaaacg catcgacaag cggatcgaaa 3493501 caaaatactg cgatcgaaaa acagcatcga ttgaggaagc cttagcttgg gctgaagagg 3493561 caaagctggc aggaaaacct ttgtccattg cacttctcgg aaacgcagct gaggtgcatc 3493621 acacactttt gaaccgaggc gtcaaaattg atattgtgac agatcagaca tctgcccatg 3493681 accctttaat cggttatgtt cccgagggct attcccttga tgaagctgac cgtttgcgtc 3493741 aagacactcc agagctttac gtgcgccttg cgaagcaaag catgaaaaaa catgtcgaag 3493801 ccatgctggc ctttcagcaa aagggctcta ttgtatttga ctacggcaac aatatccggc 3493861 aagtcgcaaa ggatgaaggg ctggagaatg ccttcgattt tccggggttt gtccctgcct 3493921 acatccgccc cttattctgt gaaggaaaag ggccgttccg ctgggcggcg ctttccggag 3493981 atccggcaga tatttaccgt acggatgcgt tattaaaaga gctgttcccg acaaataaag 3494041 cccttcaccg ctggattgat atggcacagg aaaaagtcac cttccaaggc ttgccgtccc 3494101 gtatctgctg gcttggatat ggagaacgaa aaaagatggg cctcgccatt aacgagctgg 3494161 ttagaaccgg ggagctaaaa gcgcctgtcg ttattgggag agatcatttg gactgcgggt 3494221 ctgtcgcctc tccaaaccgg gaaacagaag cgatgaagga tggaagtgac gctgtcggtg 3494281 attgggctgt gctaaatgcg cttgtcaaca cggcggcggg tgcaagctgg gtttccttcc 3494341 accatggcgg cggcgtcgga atgggctatt cccttcatgc cggcatggtt gcagtggccg 3494401 atggaagtga gctggctgac gagcggctcg cgcgggtctt aacgagcgac ccaggaatgg 3494461 gcattatccg tcatgcggat gcgggttatg aacgtgccgt tgaagtagcg aaggaacagg 3494521 acattatcgt gccgatgcaa aaataaagga gtgatgacat gccaaagcaa attgatacga 3494581 ttctcatcaa catcggtcag cttttgacga tggaaagcag cggtccgcgg gcaggcaaaa 3494641 gcatgcagga tcttcatgtg atcgaagacg ctgttgtcgg catccatgaa cagaaaattg 3494701 tgttcgccgg acaaaaaggg gctgaagccg gttacgaggc agacgaaatc attgactgtt 3494761 cgggacgcct tgtaacgcct ggcctcgttg atccgcacac ccatcttgta tttggcggat 3494821 ctcgtgaaaa ggagatgaac cttaagcttc agggcatttc atatttggat attctggcgc 3494881 agggcggcgg gattctgtct acagtcaagg ataccagggc ggcttcagaa gaagagctgc 3494941 tgcaaaaagc ccattttcat ctgcaaagaa tgctgtccta cggcacaacc acagcagaag 3495001 tgaaaagcgg ctacggcttg gaaaaagaga cagagctcaa acagttgcgt gtcgcaaaga 3495061 aactgcatga aagccagcct gttgaccttg tttccacatt tatgggagcc catgcgattc 3495121 ctcccgaata tcaaaacgat ccagatgatt ttctggatca aatgctttcc cttttgccgg 3495181 aaatcaaaga gcaggagctc gccagctttg ctgatatttt tacagaaaca ggcgttttta 3495241 cagtcagcca atcccgccgt tatttacaaa aagcagctga ggcaggcttc ggattaaaaa 3495301 tacacgcaga tgaaatcgat ccgcttggag gtgctgaatt agcaggtaag ctaaaggccg 3495361 tctcagccga ccatttggta ggtacatcgg acgaaggcat aaagaaattg gctgaggcag 3495421 gaacgatcgc cgtcctcttg ccgggcacga cattttatct tggcaaaagc acatacgcca 3495481 gggcaagagc tatgattgat gaaggtgtat gtgtcagctt ggcaacggat tttaatcctg 3495541 gcagctcgcc gactgaaaat atccagctga ttatgtccat tgccgcgctt catctgaaaa 3495601 tgactgcaga agaaatatgg cacgcggtca cagtcaatgc cgcatatgcc ataggaaaag 3495661 gagaagaagc cggtcagctc aaagctggcc gctcagctga tcttgtcatt tggcaagccc 3495721 cgaactatat gtatattccg tatcactacg gggtcaatca tgtacatcaa gtcatgaaaa 3495781 atggaacaat tgttgtcaac agggagggag ccattcttgg ataagtaccc ttttctcaga 3495841 gaggccggat cttcgtttaa agaccgggat gtcacaaaaa tgagcgacct gatcgcaaca 3495901 tgggacggcc aggacattaa gggaccggcg ttgataggtg tccccctatc aaaatcctcc 3495961 atcagtcatt caggcgcttc ctttgcaccc ggaacaatac gccaggctct gaaacattca 3496021 tcagcctatt ctgctgagct tggagagcac gtcgtatcag agcttctata tgacctgggg 3496081 gatatcgata ttcatgtcac tgatatcgta aagtcacatc atcacatttt ccaaaccatg 3496141 cacgctctgc tttcggatca tccggattgg gtgccgctca tacttggggg agataactct 3496201 atcagctact ccacaataaa agcgatagca caaacaaaag gaacgacagc ggtgattcaa 3496261 tttgatgccc atcacgatgt tcgcaatacg gaggacgggg ggccgacaaa cggcaccccc 3496321 ttccgccgcc ttttggatga agagatcatt gaaggtcaac atttgatcca gctgggtatc 3496381 agagaattca gcaacagcca ggcctatgaa gcatatgcaa aaaaacataa cgtgaacatt 3496441 cacacgatgg acatgatccg ggaaaaagga ctaatcccaa cgataaaaga gattttgcct 3496501 gttgttcaag ataaaacaga tttcattttt atatctgttg acatggatgt cttagaccag 3496561 tcccatgcac ccggctgtcc agcgattggc ccgggcggcc tctatacaga cgaattgctt 3496621 gaagcagtca agtacatcgc acaacagccc aatgttgccg ggattgaaat tgttgaagtc 3496681 gaccctaccc tcgattttcg agatatgaca agcagagctg cagctcatgt tctgttacac 3496741 gcattaaaag gaatgaaact ctccccattc aagtgatctt ctggcaggtt gtattttggg 3496801 tataagaaac tcatctgcct aaggaatggc agctaaaagg agggcgagac agtgaatctt 3496861 caggagaaca gcagccaaca gctaaaacgc acaatgaaaa gcaggcacct atttatgatc 3496921 tcattgggag gcgtcatagg cacaggactt ttcctcagta cgggctatac gctacatcaa 3496981 gccggacccg gcggtacgat actcgcttat gtaatcggcg ggttgatgat gtacctcgtc 3497041 atgcaatgtc tcggcgaatt gtcggttgcc atgccggtga ccggctcttt tcaaaaatat 3497101 gctacaacat ttatcggtcc atctaccggt tttatggtcg gcatcatgta ctggatcaat 3497161 tgggtggtga cggtaggctc tgagtttacc gcatccggta ttctcatgca gcgctggttc 3497221 cctgacagca gtgtatggat gtggagtgcg atttttgcag cccttctttt tatatgcaac 3497281 gcattttcag ttaagttatt tgcggaaact gaattttggt tttccagcgt aaagattgtc 3497341 accattattt tatttatcat tttaggagga gccgccatgt ttggcctgat ctctttaaac 3497401 ggaacggcgg atgctcctat gttgtcaaac ttcacagatc atggcgggtt gtttccaaat 3497461 ggctttctcg ccgtttttat cgcgatgata tctgtgagct tcgccttttc cggtacagag 3497521 ttaatcggcg ttacagcagg agaatcagca aatcctcaaa aggatatacc gcgatccatc 3497581 cgtaatgtcg catggagaac cgtgattttt ttcattggcg ctgtcttcat attatccggg 3497641 ttgatttcat ggaaggacgc aggcgtgatt gaaagcccgt ttgtcgccgt atttgcggag 3497701 atcggaattc cttacgctgc tgatattatg aatttcgtaa tattaacagc cttgctgtct 3497761 gtcgccaact caggcttata tgcttcgacc cgtatgatgt ggtctttagc aaatgaaaac 3497821 atgatcagct cccgttttaa gaaagtgaca tctaaaggca ttcctttaaa tgccttaatg 3497881 atcagtatgg ctgtatcttg tttatctctc gtttccagta tcgtggcccc tggaactgtc 3497941 tatgtggtga tggtcgcaat tgctggattt gcaggagtcg tggtctggat gagcattgcc 3498001 ttgtcccaac tcttgtttcg aaagagattt ttgaaaaaag ggggggatgt aaaagatctg 3498061 acatttcgca cgccgcttta tcctcttatg cctatagccg ctctcttatt atgttctgct 3498121 tcttgtatcg gtcttgcttt tgatcccaat caaagaatcg cacttttctg cggagttcct 3498181 tgtatcatcc tttgctatct catctaccat ttcaaaagaa atgttacaaa agcgaaaaaa 3498241 atcagccaag aggaatatcc agccgatcac atcctataat taaaaaagca caccccgctc 3498301 agcatgggat gtgctttatt ttttattctg taattaacgt atgaatcagc ttcggcgcct 3498361 tcgcttccgc ggcgatgcgg atgttgtcat agacttttgc gatgacttca tcgacgtttt 3498421 ctcggttagc gtaaagcgtt acgagcggtt cccctttttc tactttgtcg ccgacctttt 3498481 tgcggagcat gatgccgacg gctaaatcga tttcgtcttc ttttgtggcg cggccggcac 3498541 ctaacagcat cgccgcgacg ccgatttcgt ccgcgacgat ttcagagacg acacccgctt 3498601 ctttggcagg cacatcaatt tgatatgcgg cttgcggaag cttagacgga tcgtcaacaa 3498661 ttgagctgtc gccgccttgg tttttcagga aatccttgaa tttctcaagt gctttgccgt 3498721 ttttcatgac ttcttccagc ttcgctctcg cttcgtccaa tgtatcggct tttttcgcaa 3498781 gcacaaccat ctggctgccg agcgttaaga caagctcatg aagatcctca ggcccctcgc 3498841 ctttgagcgt gtcgatcgct tctttgactt caagcgcatt tccgatcgca aagccgagtg 3498901 gctgggacat gtctgaaatg acagccattg tttgacggcc gacgttattt ccgatgcgta 3498961 ccatcgcttt ggcaagttca gctgcgtctt cttctgtttt catgaaggcg cccgctcccg 3499021 tttttacgtc aagcacgatg gcgtccgccc cggcagcgat ttttttgctc ataatcgagc 3499081 ttgcaatgag cggaatggaa ttgaccgttc ccgttacatc acgaagcgcg tacagttttt 3499141 tatcagccgg cgttaaattg ccgctttggc cgatgaccgc aaccttgtcg cggttcacaa 3499201 gtttaataaa ttcatccttc gtcagttcca cgtggaagcc catgattgcc tctaacttat 3499261 caatcgtgcc gcccgtatgg ccgaggccgc ggccggacat cttagcaacc ggcacatcaa 3499321 gagccgcaac aagcggagcg agaacgagcg ttgtcgtgtc gccgacgccg ccggtagagt 3499381 gtttatccac tttaattcct tcaatggcag aaagatcaat cgtttcaccg gagttcacca 3499441 tagccatcgt caagtccgcg cgttcacggt cactcatatc ctggaagaaa atcgccatag 3499501 caagcgcgct tgcctgataa tcaggaatgc ttccatctgt atagccgttc acaaaaaatt 3499561 gaatttcttc agtggtgagt tcttttccgt tttgtttttt gatgatgata tctaccattc 3499621 tcatgtttgg tcaccgatcc ttttcgatta agttcagtaa atcaagccca caattgctgc 3499681 tgataaaaag ctgacaagcg tagcaccgta taataatttc aagccgaaac gagcgacgac 3499741 atttccttgc ttttcattca gtccttttac ggcaccggca atgattccga ttgaggagaa 3499801 gttcgcaaat gacacaagga ataccgatac gatcgctgtt gtacggccgc tgaaatggaa 3499861 accgttttgc gtaagcgacg tcatggcgac aaattcattc gataccattt ttgttgccat 3499921 aatgcttccc gcattaacag cttcattcca tgggataccg acaagaaaag cgaatggagc 3499981 aaacacatat ccaagaatgc cttggaacga aataccgaat actgcattaa aaatgccatt 3500041 gatcaatgca ataatcgcga caaatccaat cagcatcgca gcgacgacaa ccgctacttt 3500101 gaaaccgtca agaatgtatt ctccgagcac ttcgaagaag gattgttttt cttcttcctc 3500161 aacacgaagc atatcctctt cttttgcaac ctcgtacgga ttgataatag aagcgataat 3500221 gaaaccgcca aataagttca aaacaagcgc tgttacaaca tattccggtt tcagcattgt 3500281 catatacgca ccgacaatcg acattgatac agttgacatc gcagatgcgc aaagcgtgta 3500341 caagcgctgc tgatttaaaa gaccgagttc tttcttcaag gagataaata cttctgactg 3500401 ccctaaaatc gcagaagcca ctgcgttata cgattccaat cttcccatac cgtttacctt 3500461 gctgagggca aggccgatat atctaatgat aaacgggagg actttccact tttgcagaat 3500521 cccgatcaga gcggaaataa acacgattgg caagagaaca ttcataaaga atgtcgtttg 3500581 gtccgcattc accaagccgc caaacacaaa gttaattccc tctgccgcgt attcaagcag 3500641 gtaaccgaat ccttttgcaa atcctcccac gaggaaattc cctattccgg tattgaggag 3500701 aatgtagcca agaataaatt gcaaaatgag cataacaaca attgggcgga tcttaattct 3500761 ttttttgccg ctgctcgcga tccacgcgag gcctaaaaac acgattaaac cgataatccc 3500821 aatcaaatac ttcatatgtg tttctccttt atttgtattc gcttacaatt actgtttcct 3500881 cagaaaacgg aaagcagtct gccttccgtc agctcttaat agttgtctcc gcctgatgca 3500941 ttttctcctt ttacgataga aacgcctgcg ctggcgccaa ttcggcttgc tccggcctct 3501001 accattgtgt ctacatcttc tttcgttctg acgccgccag atgctttcac gccgatatca 3501061 ggccctactg ttttgcgcat taaggcgata tcttccttcg ttgcgccgcc tgtagaaaag 3501121 cctgttgatg tttttacgaa atccgctccc gcagacaccg ctaaacggca tgcacgttct 3501181 ttttcttcat cagtcagaag gcacgtttcg ataatgactt tgacaagcgc ttttccggct 3501241 acagcttcca ctacaccgcg gatatcagct tccaccacat cgtcttcctt gtcttttaaa 3501301 gcggcaatat taatgaccat atccacttca gtggcgcctt ttgaaatggc gtcttttgtt 3501361 tcgaacgctt ttgtttcagt tgtattggca ccgagcggga agccgatgac cgtacaaacg 3501421 tcgactccag ttcccttaag ctcttttgca gcaagctcca cccatgtcgg attgacacat 3501481 actgaagcaa atttgtatgt tttcgcttct tcaattagtt ttagaatgtc cgctttttgt 3501541 gtatgcggtt tcaaagctgt atgatcaatt atgttggcta atgacatcct tcgcacactt 3501601 ccttttttgt taagatattt tttagcataa ccgacttttg aacatatgta aattggtaat 3501661 tgaaattttg ttcaatgaaa ggtttgaacg tgtcacaaat cattaacaag cgccctcgcg 3501721 gtatgctggt caatgattaa aacgttggca tattttccgg ttaatgctcc gtgaatggaa 3501781 gatacttttc tgcttccgcc ggcaactaaa atggagcgtt ccttcagtct aaggtcttga 3501841 agctcaacac cgatggtccg gtcattgatg gcgctgctgc aaatattccc tttcgcatca 3501901 aaaaagcgtg aacaaatatc cccgacggcc tgttttttca gcagggcttt ctcttcttcg 3501961 ttaaaatatc cgagccgaaa caacagcgct tcatcacgga cagtcccgac cgtaaagaga 3502021 gcgatattcg cctgcttgcc catctcaatg atccgttcaa tatgacggtc tttctccacc 3502081 attcgcttca catccgcatt atcaaacacg acgggaagcg ggagatagcg cggcatcgtt 3502141 tgaaaagcct ctgcaaacag ctgaatcgtt tcagccgaat acgtgtttac ccgggaatgg 3502201 ctgatgccgc ctttcagctg gacgacctcg acgcctttta cctgcttcgg ctgcatgttt 3502261 tgcgcgattt gatacatggt ggttccccag ctgacgccga caatgtcgcc gtcttttacc 3502321 gtttcatgca tatattctgc accatagcgg cttaggtcat gtgtaattcc tgcataatcg 3502381 ggtgtcgggg aaaacacaac atgcgcctca aggagcccgt atttctcttc aagtatggaa 3502441 ccgagcgcat ccaaatcctc aaaagggtcc atgacgcgaa tctggacata ccctttttcc 3502501 tttgcatatt gcagcagccg ggaaacggtt ggccttgaaa tgttgagctg ctcagcaatt 3502561 tgctgctgac tgtagtcaga ctgatagtaa agccttgccg cttctatgct taattgctgt 3502621 ttttcccgat ccattctgca cctccctgtg gatcagtcct gataaaactg cttttgattt 3502681 gcttttatta tacaggctgg cgccggcttt catccacctg atttctaaga aactgaaaaa 3502741 cgctctgggc gcggacctgc ccagagctta cttctcccaa gtcatatgct gataaatgcc 3502801 tttcataatg gcgtacattc catataggat caggcctaat gccaatatag acagaatcaa 3502861 tttgccatgc ggctgctgcg cgagttctgc gagcgcgccg tcaaagcctc ttgtgtcgtc 3502921 gggatcagcg gtcatggctg tcttgatgag aaaatagccg atagccgaga aaataatggc 3502981 ccgggcgata ttgcctgcgc gtcctgtgtt tttcgtgatg catatcatct gtttgttcat 3503041 ttttgatgta tcgaattctt tcataaaagc agcccgaacg cctttcataa attgaacaat 3503101 cgcaaatacg ataaaacccg cacccgtaag ccctgtgagc cattggccga acggctgcgc 3503161 caatacataa gcggaccacg tctgttctga agtgccgccg tccccttggc caaacacaaa 3503221 tcgcaaggca ttccaagcga tggatgtgta aacagcggca ctgaaaaagt ttcctattct 3503281 ccgcgacagg cctcgcctgc tgtttccgtg cccctccgtg tccttgatcg cgcttaacac 3503341 catccagatc acatagccga taaggccgat gcctataaaa aaaagcaata gtgacccata 3503401 cggcatgcgt gatagcgttt ggagagctcc gctcgaatct ttggcgcggc ctgccccggc 3503461 agccgtcata aaagccaaaa ccccaagcag aataaaaacg ccgccgaatg caaaataacc 3503521 aagcctcccg aatcgtttga tccaaggctt ggtttcctgt tttatttttg acatgtaccg 3503581 gtctttcacc gccatgtgtc caaccctctt tcacagaaat ctttactgta acattcccga 3503641 ttgaacaaag ttgaaacagc tcctgcctca gctatggctg gctgagatac gtttttgctg 3503701 tttagctgat tgtgcaggtg tcatccaagc agccgctgcg gcagctgtga ctccgcctgc 3503761 taatttccca atgatcatgg ccgccgccat ttcttttttc attccagcta caaaaccgag 3503821 atggctgccg agtacaaagg cgccgctgac cgcaaacgcg acattgatga cctttcctct 3503881 cggcgtcata tcctttaatg aagccagcat tgggatatga tgcgccaaag aggtcactaa 3503941 gcctgctgtt gctgtctcat ctaaatgaag gcatttcccc agagcctgaa gcggtttttt 3504001 aaaggttttt gtaataaatg ccgtcatcgg gaacgcccct gccagagcaa tggcgatggt 3504061 ccctgtcgtt tgtatccctg tctcgacatt ctccattccc ggaatcagca caatgccggt 3504121 catcgtttca acagaaacag ctgcaagccc gataatcgca accatactga ccgctttccc 3504181 gaagagatga aacaactgaa tcattctgtc ggtgtatcgc cataacccaa aagcgatgac 3504241 agcagataac agactcggga tcagaagatt tttacctatc atgccgatgt caaagcctgc 3504301 gcataatccg ccgattaagc aaccgatcgg cactgtgcac agcccgatta atatgccttt 3504361 cgcaaaatac ggatgatcct ctttttcgat gatgccaaga gcgacgggaa tcgtgaagac 3504421 gattgccggc cccatcattg ttcctaaaaa cacccatgaa aacagcccgg cctgcggatc 3504481 tttcgccatt tctccagcca gcgcatatcc tcccatatca atcgccaaaa tggtgttcgc 3504541 aaaggaagaa ggatccgcgc caatcgctgt gtaaaacgga gcaacaatgg gaatcaagat 3504601 tgctgccagc acgggcgcca gcgatacaat tccgatcatg gacagcgcca gcggccccat 3504661 agccttaaag ccgtccgcaa accgctcgcc tagcccccat ctgtttccca aacaataatc 3504721 cgctgctccc catagtaaaa aggcagccaa aatgaataca accgcgtcat tcaccgtcat 3504781 ggttttctcc tttttcaaac gtatgattgg ttttatcata tcatctgaaa tcaccgaata 3504841 gagttgatct tattcaatat gagctaaaaa ttcttttata tcggcttttt caacggctgt 3504901 tataatgcgt cgcgcttttt cttgcgggac cgttaatgtc aatttttcta ttatgtcttc 3504961 ttcagacagc tcatttcctg gtgccccttt tgggcagtcc acacgcgctt cgcaaatccg 3505021 gccgtctgat aaataggccc ggacaatcgt gaaacggcct tttggaacgg catgaggagc 3505081 cggctgaata gcattgtcat atacgcgctg aattcgcccc attgtcgttt gaaccccgtt 3505141 tgggatcggc tggctgctga aatgttcaac ggtcaggccg tgtccatgca aagcaagagc 3505201 aatcacatat tcaacgctga aacggccttc ctctccagct tttggagatc tttccgtcaa 3505261 tgcagcatct ccgcctggcg gaaatatcac ttcaatacgt tcggtattgg cagcagaaat 3505321 ggtttcttcg gagataagct gtcgtaccgc atctgcagca tggtgtgccg cggaacaaaa 3505381 tggatagatt ttaaaccata gacccggctg cacaattctc cacggtgccc cccaatcgtt 3505441 tagcaaagtg tgttgtgctt tctcaacgtc accgtacaga ctgaagaaac cagtttctcc 3505501 atcaagtgcc gtgcgggacc cgccaaattc tgattgggcc agcttaacgg ccagcaagcc 3505561 agcctgagcc gccaaaccgg cgtgcagcgg tttcatttct gttccaaatt gcaccctcat 3505621 cccagcagat tgcgtagccg caaaaccaat tgctttttcc aactcttcct gagtcagctc 3505681 ctcagcataa cctacggcgc aggcagcagc gatggcacca agcgtacctg tattatgcca 3505741 gcccttctca tagtggcggc tgccaattga ttctcccagc cgtgccatca cttcaacacc 3505801 aacaacataa gcgccaagaa gccgctcgtc atgtccgcga gcggcagaag caataagggc 3505861 cggtacgatg actgcactgg ggtgtcctct tacatcggag tggacatcat caaaatccaa 3505921 tgcatgggcg ataaatccat tgagcatcgc ggattgtaat ggcgcggcct ttttgccctg 3505981 tccgataaca ggaacaaggg gccggcctcc ttcatcctct atcagacgga ggagcttttg 3506041 aattccttta tcttctcttc ctgcgaatga agcggcagta aaatcaagta atcccttttt 3506101 tgcttcgtga atcgcgtcaa ctgaatgctc aggttgtgac gttctcacag cctctgcaag 3506161 acctgctgtc agcccttgtt tgctcatttg atggtctcca atacaataac cgccagctcc 3506221 gcaaagtatt gagaggcaac cgtaagggct tcttcatcca gtgtaaaggc cggatgatgc 3506281 cactcctccg tcccgttcgt tcccatccag acaaaaaatc ccggaatctt ctcttgatac 3506341 agagcgaagt cttctccgcc cggagactgc tcagcgtgaa cggtttgata gccaagccgt 3506401 gccgcagctt cggatgccgc attcaaaaat gtgccgtcat tctgaacgga aggcaaataa 3506461 ggaaaccact tgaattctgc ttgtgcccca tagcccgctg caattccttc agccactcgt 3506521 ctcatatgct cgggaacagc ctgcctcgct tctttttgaa aggttcgaac cgtcccctcc 3506581 atttcagctt ggtctggaat tacgttccac gaggtgcccg cctgtactct tgtgatactg 3506641 acgactgcgt tttgcagtga gctgatattg cggctgacca cagattgcag cccgctgatg 3506701 atttgtccgg ctgcagcgat tggatcaata ctgttatttg ggatgccggc gtgcccgcct 3506761 ttccctttga tgacgatctc aaatcggtca acacttgcca tgagcggacc ttcctttaca 3506821 ccaatggtcc cgacaggcag atccggctta ttgtgcatgc cgaaaatcgc agaaacgcca 3506881 ttaagtacgc cagcttctag aacctttctt gctcctgcgg caatttcttc ggccggctga 3506941 aagataaagc ggactgtacc tttcagctcg gcccttcttt gattcagcaa catcgctgtg 3507001 ccaataatag aagcagtatg aaaatcgtgt ccgcacgcat gcattgtgcc atcaacctta 3507061 gatgcaaatg gaagattcgt ctgttcttgg atcgggagcg cgtcaatgtc cgctcgtatt 3507121 gctatcacgg ggccgtcttc ccgtcctttg atttctgcaa tcacaccagt cttcaattga 3507181 gggacatcaa gtatttcgat ttgctcctcc tcaagccaac ggcggatttt tttcgtcgtt 3507241 tcaacctctt gaaatgacag ttcaggatgt tcatgaagat cacgccgcat attgattaaa 3507301 cgggtatgaa acgctttgtc ggccattgtt cttctcccct tcttatataa gctctgcagg 3507361 ctctcccacc tgcttgataa atcgtttcgt ccgttcgttt ttcggatggt caaacagttc 3507421 ctctggcgtt ccctgctcga taatatggcc gtctgccata aaaatcactt gatcagcaac 3507481 ctcttttgca aacgccattt cgtgtgtaac aatgatcatc gttgtttgtt tttccgcaat 3507541 ggacttgatg acctgaagca cccctgtgac gagctcaggg tcaagcgctg acgttggttc 3507601 atccagcaaa atcgcatgcg gattgaccgc aagcgcccgc gcaatgccga ttcgctgctg 3507661 ctggccgccg gacattgtga ttggatagct gtcagcctta tgctccagac cgacttgttt 3507721 cagaatctcc attccaatac gtttcgcttc gtcgcgtggt ttatgttgag ccacgattaa 3507781 agcttctgta atgttttgca gagccgtttt atttttaaac agattgtagt tttgaaagac 3507841 catggccgtt tgctggcgaa gccgatgtgc ttccttgcgt gtaaactttt ccgcattcag 3507901 tttggcttct ccgatttcaa taaggccttg atccggacgc tctaatagat ttaagcaccg 3507961 gagaagcgtt gattttccgg aaccggacgg accgatgatt gccaccactt ctccgcgttt 3508021 cacttctaga tcgattccgt cgagcacgac gagatcttta aacgctttgc gaatattttt 3508081 tactgttatc aactgatttc acctctaagt ccggtatggc ttgctcatgg cacgttcaaa 3508141 caagtcctgc aaaatgctgt agataatggt aagaacccaa tagacgatcg caaccgccaa 3508201 atacgtctca aaatatttga ggtttcctga agcgtacatc ttcccttggg cgaacatctc 3508261 catgacccct aatgtaaagg ccagtgacgt ttctttcagg agcccgataa atgtattgcc 3508321 cgttgccgga atcgcatttc ggatcgcttg cggcaaaata atccgtctgt atgcctgaaa 3508381 ttttgtcata ccgacagaca ggcacgcctc cagctgcccg tcatcaacag aattgagggc 3508441 ggcccggaag atttctgcca aataagctgc gttttttaag cttaacccga tgatggcagc 3508501 tgtgagagct gtcattttgc tcatctctgg aaatagctgc ggcagcccgt aatagattaa 3508561 gaacagctgt acaagtgtcg gcacgcctcg gaaaaaggat atatacagct ttgacagctg 3508621 atgaagcact ggaattttgt tttttgtaat gagtgcgaga ataagtcctc cgataatggc 3508681 aaaaatcata gctgctattg ccataaacaa ggtgatcgga agggcctgaa ttaaagtcgg 3508741 gaacgctgat atcatgaatt cccaatcaat cgtgttcatt ctggtgagtc accgccgttt 3508801 cttaatgctt ctgttctact gtgatatctt cattaaagta tttttcagag agttttttca 3508861 gtgttccgtc tttacgcaat tcatctaggg ccttattgac ttttttgcgg agcttgtcgt 3508921 gcgcatcgtc cttggcaaat gggaatgcaa cctgttcgta aacaatcgga tctcctgcaa 3508981 gctttaatgg caaaccggtc ttcttgattt gcgcgatcaa tacagttcgg ctgttgacat 3509041 aagcgtctac acggccgtac gcaacatcct tcagcgtacc ctcttgtgtt tcgtacgttt 3509101 tgatattgat ttttttatca ggatctttgc tttcaaggtt tttcgcgtgg tttgaaccga 3509161 gaacggctgc gactgtcttg ccttttaaat cgtctactga tttgatgtct gtattgtctt 3509221 ttttgacgac aatctgtgtt cccgcataag cgtatggttt cgtaaagtta tacgtttcct 3509281 tacgttcgtc tgtcacagct acctggttgg aaatggtgtc aagcttgcct gtttgaagct 3509341 ctcccatcag cccgctgaat tcaagcagct tccagtccag tttcatgtca attttcttag 3509401 cgactgcttc catcacttcc acgtcaaagc ctgtcagctt tccgttttct ttataagcaa 3509461 atgggtaact ttgtcctgtc gcaccgacat gaagcacatt gtcatcctct ttactgctgc 3509521 tgtttccatt gccgcaagct gagagcaccg ctaataatgc agcaacgacc agcactgtcc 3509581 attttttcat cttcatttga ttttcccgcc ttttctattt ttatagatca tgtcgcaatt 3509641 gttttttcat atagactgtg atatgccctt ttccaaggtc ttgttcacct gagcggacat 3509701 atccttttcg ttcgtacatc tcaatcagcc acggatgctt atccgctgtt ccgagtgaga 3509761 caaacggaac ctttaacgta tcgcgaagga ttgtttcctc cagccattga agcagctttg 3509821 ttccgattcc ttttttaccg gtgtcggggt ccacagcaaa ccaccagata tgcggaacgc 3509881 catacggtcc cggctgtttt ccccaaggca ttctcaaggt gatggtcgcg atgatccgcc 3509941 cgtcttcttc catgacgtag caagcatttt cccgaatatt tttcagcacc aaatccaaat 3510001 ccgcatgagc agcagcaaaa cgaatgccga gctttcgaat cggttcataa gcccgcaatg 3510061 tcagctcgag aagctgttcg gcatcacgtt caactgcaag gcggtatcgt ggcttcatct 3510121 agcgttcctc cttactttgc atagcggttt accggctttt ccaaaccgaa gtgctctcgt 3510181 aatgttgtgc cttcatattc ttttctgaac acgccgcgct cctgtaaaat cggaaccact 3510241 tgatcaacaa acacttcaat tccttctgga agaagcggag gcatgatgtt aaacccgtca 3510301 cacgctttcg tatccaccca ttcctgcatc ttgtcggcga gctgctccgg cgtgccgacg 3510361 aagatatggt ggcctctgga gcctgcaacg tatttgtaaa gctctcgtat cgtcatattg 3510421 tcacgttcag ccatctcctg aacaagcttg aagcggctct tcaccgcatt ggaagcttcg 3510481 gcgtcaagct tcggcagcgg cccatcaagc ggatatgccg acaaatcaat tccgcctaag 3510541 taattttgga gaatttgcag accgacagat gggataatca gatcttggag ctccttgtat 3510601 ttggcttgcg ctgcttcttc tgtatcggca atgattggga aaatacccgg cataatggca 3510661 attttttctg gatcacgtcc gaattccgca gcctgttctt taatggattg ataaaattct 3510721 tgagctgatt ccaggtggtt ttgtgctgtg aagatcactt cggctgtttt ggcagccagc 3510781 gcttttccgt ctcctgatga tcctgcctgg ataatgaccg gctggccctg cggggttctt 3510841 gaaacgttta gaggtccgcg aaccgagaaa tattctcctt tgtggttcag ctcatgcatt 3510901 ttttctttgt caaagaattc acccgtttct ttattacgga taaaggcgtc ctcttcccat 3510961 gaatcccaaa gcccctttac aatctcgaca aattcctctg cccgctgata gcgcaaatgg 3511021 tgttcaaggt gcttttcacc gctgaaattc agcgctgttg attcaataga tgaagtgacg 3511081 acgttccatc cggcacggcc attggacaga tgatccaatg acgcaaactg tctggcaata 3511141 tggaatggct cgctgtatgt agtggaggct gttgctgtca gtccgatttt tgatgtgacc 3511201 tgcgccaaag cagagagcag ggtgaatggc tcaaaccttg ttaatacatt tggatgtgat 3511261 ttgctgtcaa ttgaaaggct gtccgctaaa aacagcatat ccagcttgcc tcgctccgct 3511321 gttttcgcaa gctctttaaa ataatccaaa ttcatgctcg catctgacgg cgcgtccggg 3511381 tgccgccaag acgcaacatg atggcctgta cctgctaaaa atacccctaa tttgatttgt 3511441 ttctttttgc ttgtcatggc gatactcctt ttatcatgtt tttaggctga ataatccgaa 3511501 aaataaactc ctatattcct agtcgtttaa tatgaataaa tcaaaatgta cctttgtctt 3511561 ggacgtttgt caatgagtta agattaattt tttctattca agcgaaaaga cccttgcgtg 3511621 accatgaggg aacggcattg attcattcaa ctagtgcaac ctctatatcg gcaagaaaac 3511681 tgagtctaat gaagcaaaga ctcagttttc ttccaataat ttcatataag atttcgccat 3511741 ttcctttgcc ttttcttcgc ttttgcaaac cgcctatcca ttcagacgcc gtaacgattg 3511801 tataaaaaaa cagctgactc cagatattca aaccggaatc agctgattga tgtgaattaa 3511861 ttaagctcat gaatactctc ttctgcttta gcggaaaaca ctttaggctc caaacagtca 3511921 aggtcttcat gaaataaatt tactttttgg atttgccgat tgtcatagtg gtggaaatag 3511981 tagtttccag tttcgttgca catcacggaa gtatattgcg tataatgaat ttcgtcttct 3512041 tccgttatca ctgcgccctt tggtatcgtc atatttgcca aaatttgaaa agcggctgtt 3512101 acacctttcg tttcatcggc cgccggctct agatgttctt tcaaataaac agctctgaca 3512161 aaccgggaag gcggtgtata atcccccggc agaccaacag ttcctaagcc ttggccaaaa 3512221 gcagaaaggg ctaatccgcc catctctttg ctctctaatt gcttcggtct gattcctgta 3512281 tattgctgca gattggttac atgccatata aagtcggggc tgttcgtcat gacaccaggt 3512341 tgattatcat agactttgag gccgtctgct cttggttcta tcgtcaggtt tcggcccgtc 3512401 cggtctgaca atatccagtg aagcggtaaa actgtatcca atagatctaa ttttttctct 3512461 acaatcgtta aagatcgaat cttttctttt acgtcttcca aagactgaca gactgacagc 3512521 acccatgtca caaactcatg cgggacaatg tgaacggtat cttcccgtat cgttttttcg 3512581 tactccgcat agcccggaaa ataaagcgcc gcacaagata aaccgctttc attaatgccg 3512641 tcggcaaata atatatttcc aagttttctc cccataccga taaacgcgta ctgtgtctga 3512701 tgggcccttc cgtcagcttc actgttccag ctgtaacggc gcggatagag aatcacctct 3512761 gtccccagct gaaatgcaaa atccattgtt cttgctaata catgtttacg gtcagcagtt 3512821 tccaatgtaa gacttgtgca catttgatca gtcccctttt caattcagat taatatcata 3512881 catattgtga acgaattggt tttatcagca taacgaaagt caaatcgatt cgtcaaagaa 3512941 ttgacattac atcaaataaa acgaaaaaat ccagccttta gaaggctgga ttttttatta 3513001 tttagccaaa acaagctcgt gaatcgcatg tgcaacgcca tgttcattat tggagcgtgt 3513061 ttgaaagttt gctgcttcca atacttctgg gatggcgttt gccatggcaa ccccgcagcc 3513121 cgcccattcg atcattgtca ggtcgttccc gttgtcgcct atgcacatga cttccgcctg 3513181 ttcaattcca agcagctgag ccagctggcg tacagcattt cctttgctgg cttccgagtg 3513241 cagaatttca taaaagaaag gcgcgcttct gaccattgta tatttttctc tcacgtcttt 3513301 tggaatcgat gtaatgacgc ggcttaagtt ctccggttta tcaataaaca tcactttcgg 3513361 gatgaggata tcttttggca cctcgtcaat cttgcggaaa tgaagcggca cctgtgtcac 3513421 ataggattcg tatacggtaa attcgctaat atcccggtta ggcgtataca aattagatga 3513481 gtcaaagaaa tgcatcggcg tcttcagctc taagctcagg tcatataatg aagtcaaatc 3513541 atcataaccg agagacagct ctgagaccac ttcatttgta tgcgtatttt gaacaagtgc 3513601 tccattatac gcaataacat agtcgccttc ttcaattaaa ttcagttcat ctaaatatct 3513661 ctgcacaccc ccgataggcc ggccggtgca aagcacaatt ttgacacctt ccgcttttgc 3513721 cgcgtgaagg gcgtcgcgga cctcctctgt tacttcatga tgatcattta aaagtgttcc 3513781 atccatatca attgcaatta gtttgtacat cctgcatctc cttcatgtcg ttttcaggct 3513841 atagtcccat catatcgttt tttctttttg atattcaacc ggaagagatg gttttctccg 3513901 gattctgttt agacgccgcc cttgtcttcg gatacgcaag cgcggtttcc gctttctttc 3513961 tgccttgacg ccgttttctg cttttttctg tttcatcagc agaaagccgg cagctagaaa 3514021 aggaatgccg gttatattca agatggcaag cttcacaccc gccgcgatga aaaagaaccc 3514081 ccatgaagat gatggattcc gtctgatcat gacgtaagcc gccatttcca gaacgatcag 3514141 gatggcatga agcactatgc cataaatcag caatacaagg gcaaaaaaca aaacataatt 3514201 cacgattgcc cctgagtaca tcatagcgcg catcatttgt ataaacgata aggactgcat 3514261 ggagccgctg atgacattag ggttatagat cgtatagtca ctaaataaat gtttgacttt 3514321 gagaaaagcc cataatataa atatccattg aatgatatgt aaaacaagcc ccgctgccac 3514381 cagtctttca gctttttgat ttctcatctt tctcctccct gccggtcttt gattcgattc 3514441 ttgtcatcgt ttttctctgt ccattttgct cccatatcaa tgtcccgttt tctcctcttt 3514501 tcagcgtgct tttgagcgga taataagggc cgaggtactg aatctcgata gacccgtcag 3514561 tgctttggga aatcaccttg tatgccataa aaggcagctg tacctctcct cttccttcca 3514621 tcacttccgt ttccacaacc tcgtcttcgg taaatgtgac tgttgctgat ttcacaccgt 3514681 ccgttggccc gggggcacgc ccctcatccc acgttccgta ataaaacggc gtctcttctt 3514741 tttgctgctg gcagcccgat accatgatgc atacagcaat taaaaacaaa atgccatatt 3514801 tgtttctcaa ggggatcacc attctttcct ccttttttgg gcgaatgccg tgccactgtg 3514861 ccaatgacta cataagttat aaggaattca cccacaagga gactgatcac atgaaccctt 3514921 atcaatatta cagccctcag ctgcctcagc aggaacctta ctatagccac tatgagtaca 3514981 atccttatcc gcagcaggat gtatacgatc cataccaaat ggacagacag ccggcattgg 3515041 aaagaagaat cgcagcactt gaacggcaaa atgaacagca gtcaagagaa ttaacccgtc 3515101 tgacaaacga agaccgccgt caaaatcggg aaattgcacg gattgccgaa caggtcaatc 3515161 agttaagcca ggctgttgaa cgccatacac gccgcctaaa tcggctcaat cagcgcctcc 3515221 gtacagtaga aaaccggctg aatatcccat ttactgcagg ggaaggcggt ttctgagcga 3515281 aacaaagaaa aaaagcggaa tacgattctc ccatctcagg gtttcgtttt ccgcatttct 3515341 tatatgttaa aacggaacat ttacataaaa agggtttgta cccagtatac aatctttacc 3515401 gttttcattc aaagatagag gggctgagga aaataattgt agttcctctt tgacggaatt 3515461 tcttttcatt caagttgcat gataataccg actcacgtca atcgatacat ggagggatca 3515521 ttcatgcata atacacaaca cggcttgcag cagctgaacc aatgccgcca aactgctcag 3515581 cagctcattc agcaaacaca gcaaagcagc cagcaatatc gccaaatgct tcatcaggaa 3515641 cagcaaaaca tccaaatgct gcagcagatt ctaaaccacg aacaacaagc tgcacatacc 3515701 attcagcaag cactgcacgg gcatgacatg gcgattcaaa agtgccagca ggttgtcaac 3515761 atgtgcaacc aaatgcaaca ggaacttact ggacaatcca gcgtcatgaa tacgaatgtg 3515821 tctacacttc cattcggcca aaacacgaca tttcagcagc aatcctacca gcagtaacat 3515881 ataaaaagct caacacaatg cgagtgttga gctttttttc ttactgttct ttgcgaatat 3515941 gtatatcctg aatagactgt ttcggtgcat gaaatctgct ctcggcttca cttcttgcct 3516001 cggcaaaagc ccgcgcctcc acatgatctt tgtagacatc cagctgaatc aaatacagcg 3516061 ggcgcacttt aaatccatga ataatggtta ccgcccataa cgggaccaca ataaaaacac 3516121 cgggcagatc gggcaaaaca aaaccaaacg caaaaatgaa aaaataaatg atgccgtaca 3516181 tgatccactt tctatttcta accttgatgc caataaataa aaaggcaaaa aaactggtaa 3516241 tggcaaaagg catgaaaata aacagcatcc accagctatg cagccattcc caagcggcac 3516301 ctctttttgt aattcccata tttttctcct cctatttacc tataataatc gattaggcac 3516361 accgcgtcac ccataaacgg gaaaaacttt ctcccttaaa aatagtgata gacggagaac 3516421 aggtttcttg ctatattatt aattgataat gataatcatt actaatctat tgagatacat 3516481 agtgggaggg ttcttgatga aaaagaacat attgctcgtg ggcatgcttg tgctgcttct 3516541 catgtttgtc agcgcttgca gcggcacggc ttctaaaggg agctcaagcg attctgcttc 3516601 cgaaaaaaca gaaatgagaa catacaaatc accaaaaggg aacgtcaaca ttcctgcaca 3516661 tccgaaacgc atcgtcactg atttttatgc cggtgaattg ctgtctgtcg gggccaatgt 3516721 ggtcggctca ggctcatggt catttgataa tccgttttta aaatcaaagc tgaaaaatgt 3516781 gaaggatgtt ggtgatccaa taagcgttga aaaagtgatg gagcttcagc ctgacttaat 3516841 tgttgtcatg aatgaagaga atgttgataa attaaagaaa atcgctccga ctgttgtcat 3516901 accttataac acagcgaaaa acgtagaaga cacagtcagc atgttcggag atatcgccgg 3516961 agcgaaagac caagcaaaat cctttatggc tgactttaac aaaaaagcgg aagcagctaa 3517021 gaagaaaatt gccggcgtca tcgacaaaga tgcaaccttc ggcatttatg aaaacacaga 3517081 caagggcgaa ttctgggtgt tcaatgacaa tggcggacgc ggcggccaag ctgtatacaa 3517141 tgcacttggg ttaaaagcgc ctgaaaaaat tgagcaagat gtcatcaaaa aaggagagat 3517201 gaaacagctc tctcaagagg ttattcctga gtatgccgca gattatatgt tcattacgga 3517261 ttacaacccg aaaggcgaaa gcaaaacact cgacaagctg gagaattcct ccatttggaa 3517321 aaatcttgac gctgttaaac ataatcgcgt gtttatcaat gactttgact cgttctaccc 3517381 gtacgacccg atttctgtca gcaaacaggt ggatatcatc accgacatgc tgatcaaacg 3517441 ggccgaagaa aataaaaaat aaaaaaacgg cacagtcatg acgctgtgcc gttttttatg 3517501 attcacttta attttgactg tacggagtcc ggcatatctt caaacttgac ttcttcccaa 3517561 gtctcgacat actttccttt cgccttcacc ttcaaatacg cgttcttccg aagctctttg 3517621 ccggcgaaaa aggtcacttc ttcttttttc ccggatgcat tatatccgtc taatgtatat 3517681 tcagtaccgc ccggactaag atgtctgcca tctcgatcaa tctgaacata gacatcttgc 3517741 tggtgaataa acggattaaa tctgtctgta acatcgttat gaaaaaagag aagcccgcat 3517801 attacggcag cagccgccaa gacggccagg attgccattg cttttttcat ctttgcactc 3517861 cccttacttg ttcatttttt tcaaatagct tgaccgcacc gcgaggaaga atagaagctg 3517921 aaaaatgaaa aaccctccga tggtgagact gagcggcccc gctacatcgg aatatccttc 3517981 cacagccaat gttctcaagg caaacagtgt atgcatgacg gcaatgacaa atggaaagaa 3518041 gaaaagaatc gccaattgta ttgtcacgct ttgcgccatt tctcgctcac tcaggccgat 3518101 tttggccagt gaacggtagc gctcccggtc ttcatctaaa tcagtgaaca gcctgaaata 3518161 taagaaactt gctgccgcga caaagaatac aattgcgata aacaggccga taaatagact 3518221 caggctcggc agctgcaccg tatcatagta agtccccgct tttgaagcaa aatcagaatg 3518281 cacgtcgata taattgccgt aaatctcatt ttgcaaggat tggctgatct caagactgtc 3518341 tttccaatga tcatagctgt agccgtataa tgacgcttta tcaccgagtg atttcagctg 3518401 atcaaaggtt tgatcattca ccgcgatgat agcattcaat gagatcagcg gttttttgac 3518461 ttcttttacc gacagttttt gatcagacag ctcccctttt tggttcagca gcttcagctg 3518521 atccggcgct tcgtttttga aattgcggtc atacgttccc gggaaataga cagcctcgtc 3518581 ttctttcagg ccgttcactt tgacatggaa gtattttgcc gcatccgatt cactgatcat 3518641 gtaaacaggg ggaacagttt ctccttcctg atagcgaaca taggaaacat ctattttgtc 3518701 tttcgtatac gtaaaaccgt gtgttttcag ttcatggtca atatctttca aatgagtctg 3518761 ttcttttgga ttgttgctgt aagataaata ctccatttca taagcggact cttccgctcc 3518821 gacggtcgat ttgtacattg cgagcacgcc tgtcgcagta aacgcaaccg cggaaataat 3518881 gctgacaata aagaacaggc gggcgttgtc ttttagacga tagacaaggt cagaaaccca 3518941 aatgatgttt ttcccgcgca gataaaaggt tttccacttc ttcagcgcgc gcagaatcca 3519001 tatgctgctt tggctgaaaa agaaatatgt tccgataacg gtgagcagta aaatgataaa 3519061 cggttcggcc ccgtggacat tgcctttaag aaccatgccg tacccgccgc acagacaggc 3519121 gatgccgaat aaggacagaa gcacggacgg cttaggctcc ggtttaacct tgccagtgcc 3519181 ctttattaat ttgataaccg tatttgatct gacaaaaagg atcgtaaact gcgataaaaa 3519241 gaaaaataag agcagaaatc cgcaggccgt aataccgagc gctttccaag gcatatacaa 3519301 aggcagcgcg tccatttcta aaatataagc gccgaccgta aagaacgtct ttgaaaaaat 3519361 gaatcctccg ataataccgg ctgcaattga catgacgccg atgatcatat tttccgcagt 3519421 aatgagcttt ctcagctgcc ccggcgtgat gccctgcatg agcagaatgc cgaattcttt 3519481 atttctcgat ttcaaaaatg cattaaccga atacagaaca aataagaaag aaaaaacaaa 3519541 gatcatccat tccgcggcgg ttaagccttt tttggcgatg ttattcaggt agccttcctt 3519601 taatgccgga tgaaacagga acatcgcaaa ggtaaagaaa atcaaaacgg aaaaggcgct 3519661 gcttaaaaag aatgcaagat aggccctttt gtttctcgtg acgtttttat aagcgaactg 3519721 aagaaaggtc atttgcgttt ccccccagca tagacagcac atcgagaatt tgttcataaa 3519781 atacttggcg gttttccccg cggtaaatct cattaaacag ttcgccgtct tttataaaga 3519841 tgacgcggcg gcagtagctt gccgaaaccg gatcgtgggt caccatcaaa gccgtgacat 3519901 gatcatcccg attcaggctc tgcaacgttt ccatgacgtc ttttgtcgct ttggaatcaa 3519961 ggtttccagt tggttcatcg gccagaatga gtgacggctt atgaatgacc gctcttgcga 3520021 tggcggcccg ctggcgctgg cctccggata cttcaaacgt ccgcttgtta agcaggtttt 3520081 cgataccgag ctttgccgcg atgccgtgca gtttttcttc cattacagac ggcgcttctt 3520141 tttcaagcgt taacggcagc atgatatttt caccgatcgt cagcgtatcc agaaggttga 3520201 aatcctgaaa cacaaatccg agctgcttgc ggcggaaatg agcgagcttt gtccgcttca 3520261 ggcgatgcgg gttttctccg ttaatcagga tatcgcctga atctggacgg tcaatcgttg 3520321 aaatgatatt caaaagcgtt gtttttccgg acccggacgg ccccatcacc gccgtgaact 3520381 cgccttcttc tattgaaaat gaaatttgct ttaaggcctg ataggacact tgtcctttat 3520441 aggttttatt tatatgtttg acttcaagca tattcgccat gaaaatcctc cttatggttt 3520501 tattcttgtt gatctgggct gctttcatgt agtgccggga cgttcaacat aaaaatcccc 3520561 ttgacataaa tccatgttat caaggggaaa caaagcgggc tatgttgttt tcttaacgca 3520621 gccttacatt tttgtaagaa atgaaaatcg aactgatgtc ccttcaccgg gagacgagct 3520681 gatgtccacc gtatgattga gcttatctgt aatttctttg acgagatgga ggccgattcc 3520741 cgtagattct tggaaacgcc gcccgttttc acccgtgtaa taagggtcaa acacccgctt 3520801 gatgtcttgt gagggaatcc cgacaccgta atctttgact tcaagcaccg tcctgtcttc 3520861 atcgcagaag acattcagct caagtctgtc actcttgccc gctgaatact tgaccgcatt 3520921 tgtgaccact tggccaatcg caaatttgag ccatttggca tcggtgtaaa tctgatgatc 3520981 atcgcaaacg ttcattttcg gataaacgcg atattgaata aaaaatcgtt tatagctttg 3521041 aataactgat tggagaagct cggacaggga aaccgcttcg attttaaaat cccgttcaaa 3521101 caggtcgagc cttgaagaat aaagaagcgt ctccagcccg aattcaatct gccggacttc 3521161 ttttttgatt tgttcaaaaa cgggctcatc ctcttcttga atgattaaat taatgaccga 3521221 cagcggcgtc tttacttggt gcacccattg attcatatac gtcacccgcg cgtcaagctt 3521281 ggcttcggtc tcatggagct tctggtgctg cagccggatc agctccatct gcttttcata 3521341 cagctctgaa cagaacactg aagaaccgag atacgggata tccgtccctt cctgccccga 3521401 gctgagccaa tgatacacgc cgcggtcttt gtaccagcga taggcaagat agcccgccaa 3521461 aataagaagc tgcacgccca atatgtaaaa caagtgagaa aaagaatgaa gacccgcaaa 3521521 ccagtaataa aagaagacaa acagcccttg aaggagaaaa agcagaatca gcactgcatg 3521581 agaccggaga aacagcttca tgactgcgcc ctcagctggt agccttcgcc ccgcaccgct 3521641 tcaatagaaa caggcgcatt cagctcccgc agtttttttc tgagccgcgt gatatacacg 3521701 ttaagtgtat tatcatcgat gaatatgtcg gtgtcccacg tcttttccat gagacggtcc 3521761 cgactcgtca ccttttctcc ccgctcaagc agcacttcca aaagcttgct ttctttttta 3521821 gaaagctcac ttttttcatc ctgaaaacgc agttcaaacc gttccacaaa gagctgaacg 3521881 ccggcatatt caaccacttt ctctccctgc tttgcggcgt actccccgta cgccctccgg 3521941 atctggcttt tgattttcgc aagcacaata tcataagaaa acggtttttc gatataatcg 3522001 tctcccccat tttcaatcgc catcacctga tccatttccc cgcttctggc agaaataaag 3522061 atgatcgggc ttgtggagtg ctggcggatc tgccggcacc aataatatcc gtcatatgcc 3522121 ggcaaattga tatcaagcag caccacatcg ggcttttccc gcaaaaagac atcaagaaca 3522181 gctgtaaaat ccgcggcgac cactgtttga tatccgtatt tttcaaggta attctgcaat 3522241 agtccgcgaa tgtcttcact gtcttccaca atcatgattt tattcaaact gaaccactcc 3522301 cgtttcttac actgctgcca tcatcataat cgttttgggc gtatggacgc aacaccgcac 3522361 aaaaaaaccg ccatctcggc ggtttctggt ctctttagcc gacctgctgc ttagctgctt 3522421 taccggctga tccgaactct ctcattttgc ttcgcactgt ctcttccacg gcttcaatgc 3522481 cgggtgtcaa atagccgcgc ggttcgtaca gatcgctgtt ttcctgaaac atgcggcgtg 3522541 tttcgtctgt ccacgctacc atacattccg tattgatatt gatcttcgcg tggccgagcg 3522601 tgatggcttt tttgatctga tcctgcggaa tcccggatgc cccgtgaaga acgaggggaa 3522661 tatcagtcat gcgggagata gcctccattt ccttaaatcc gagattcggc tcaccctgat 3522721 atttgccgtg tacagagccg agggcggcgg ccagcgcgtc gatattggtt tctttaacga 3522781 tccgctcaca ttccgtgata tccgcatagc ggaccccgcc gaccagtccg tcttccattc 3522841 cgccgaccgt gccgacttcg gcttctactg acacgccgtg ttttgcggca taatcggtga 3522901 cttcttttgt catcgcgata ttctcgtcaa tcggctgatg ggagccgtca atcatcactg 3522961 agctgaatcc ggcatcaatg gcctgtctgc agcgttccgc actgctgccg tgatcgagat 3523021 gaagcacgac cggaacggta atcgccatgt cctctattaa cgcgccgacc atggcggcaa 3523081 tcgttttaaa tccgcctaaa tagtcgacca ggcgatcgga agccgcggcg atgaccggtg 3523141 attgctcctt ttgcgccgcc tgcaaaatcg ccttcgtcca ttgcaggccg ttgatattaa 3523201 actggccaat tgcatattgc tcccgctttg catcttcaag aagctctttc atcgatacaa 3523261 aagccatatt cacccctcct ttatccatta catgctgaag tattttgata cgacatccac 3523321 tgttgttttt ttcgctgttt gaatggcttc ctcagcagtc agcttatagt attcaggccg 3523381 gaagagctca accgaaacaa catcagagaa gccgatttcc ttcagtgctg ataagtgggc 3523441 atctaagtca attgcccctt gtcccggcca tacacgatcc tcatctgtta aaaagccgat 3523501 tgggaaatct tctgtatcat caatatgata gatgaagatt ttctttccgt ccgcctgctt 3523561 taagctctca atatttgaac ccattgcatg gaagtgaaaa ctgtcaagga caagcccgac 3523621 attgtcacgg ttaactgtgt ttacaatctc atacgcctgt tcaaacgtat tgaccgtaca 3523681 ttgcggatgg ccgacaaact caagcgcgat ttttacgccg tacggctccg cgatatctga 3523741 cagctcagtc agcacgtcta cactgctctt tttgatctct tcttttacaa tcttctgctc 3523801 tgtcacaagc ggaacggcca ccacatattt cacaccgagg gttttgcatg tttccatcat 3523861 gcctttaaat tcagtgatga tctcgttgtg acccttttca tcacggttgt tgaagaaaac 3523921 gagtgcgttt aaggcaagcg gtttgatgtg gtgggtttga aaatattccg caaggtcatc 3523981 caatgaatga tcttttaagt actccggcag cttatccata gtacggattt caatataatc 3524041 atagccatgc ttttcgcata gttctaaatc cagtttaagg tttgagtttt ccaatgttgt 3524101 cgcttcatta aaacaaagtt tcatgccaga ctcccccatc tgcgttttag atatgaaggg 3524161 agttcggcag gaaggctgtc gccatatccc gccgaactcc atgctcagct tatgccagac 3524221 ctaattcttc tttcattttc ttaagcataa atcggcttga ttcatccgct ctttcatcga 3524281 cccaagcaaa tacggcattc gtcgcaattc cgtcgaactt catctctctc agttttctga 3524341 aaatcgtatc aaaatcaacc tcgccttggc caatgtccaa atgctggtga accgttactt 3524401 tcgcgtcagg cggattgacg atgtagcgaa ggccatgagc cgctttatga ttataggtat 3524461 ctgcaaataa aacatgtgtg aggcggtcgc cggcttcgtc aaacatggtc tcgatgtcgc 3524521 ctttgccgtc atcatagaag aacgtatgcg cagtcgagta gacaagattg atccaatcct 3524581 tgtcaagcgc gcggatcata tccatcgcac ctttgtgcgt ttcgataaaa tcatatggat 3524641 gggcttgaag attgagttta atgccttctt tttcaaagac tggcagaagc tcatccatgg 3524701 atttgataaa tttttcttca cttgttaaag gatcatattt tgaaccgctg aattcgctgt 3524761 tcatcaaatc cacttcaagt tcaaccgcaa tttcgattgc ccgtttccag ttgcgcactg 3524821 ctgcctggcg gcggtcttca tcgggtcccg cccagtggta aagaggaaga agcgatgaaa 3524881 gcttaacacc tgtatctctt aaaaggcgct ttaattgttt gatctttgct gaatcgactt 3524941 tcggatattt ataaaacggg caaaaatcct cgcgcggcga taattcgata tattcatagc 3525001 cgagctctgc cgttttatag accatttcct ctaaagttaa atcatcacga tacatggatg 3525061 gatccaatgc taacttcata ttttcactcc tctgtttttt agttttgaac tgttgtaaaa 3525121 gattgataga attccggttt ttccttcaat tcaacctttt ctttttgtcc agattcctgg 3525181 gcttttacac acgcgtcagt cgtgacagca gcaatatagc cgtcccatgc cgtcggtccg 3525241 ctgacctcgc ctttcttttg aatcgaatca ataaagtctt ggatttccac atcatacgca 3525301 gcgacaaagc gtctctgcca atccatcaaa atatcagtgc tgaatctgcc ttcttttctc 3525361 aagctgatgc ttgatggctc gggaagcttg atgatgccgt cttctccgac gatttcacat 3525421 tgaatgtcat agccgtattt acagttcaca tagatttcag cattgatgac gataccgcct 3525481 tttgtttcaa tcacgacgat ttgcggatct tttaaatgtg gaagcgcgtt ttttgatttt 3525541 ttcggataga tgacttgaac ggactcgtag tcatcattga cgagccagtg gagcacgtca 3525601 atttcatgaa caagcgtgtc gactacagcc atatccgttg tatagttatc tcctacagtc 3525661 gggttgcggt gcgcgcagtg aatcataaga ggctcgccga tgacatgatt atcgagcgct 3525721 tctttcagct gtacgtaacc gctgtcataa cggcgcatga agccgacttg aacaaggcgt 3525781 ttgcccactt tgatttcttc ttcgacaatg cgcatgcatc cttcagccgt tgtcgcgagc 3525841 ggtttttcac agaacacata tttctgggct ttaatcgctt tcagcacgct tgactcatgc 3525901 gcaggccccc agcttgtcac taaaacagcg tctacatttt cgtctgcaag caagctgtca 3525961 tcattcggat aaaccgtcgc gtttaattgg tattgctcaa cgaccttttg tgcagcttct 3526021 tgattaacat ccgttacagc tacaatttcc gcgcctgaca gcttgttcgt gatacggtta 3526081 atatgttctt ttccgattgc tccagttcca attacgccaa tacgtaaact cattgacagc 3526141 cactccttct gttggttaca tgattttgct ttctgttcct ttctttactt ggctctgagg 3526201 agacccgtag agttcctctt gaatttgttc aagcgacttg ccagacgtat tcggcgcaaa 3526261 gagcagcccg atgatcatac tggccgtcac acatccgaga agaattgcag ccatcgttcc 3526321 aatgccgaaa ttggtgataa tcattgggac aaacagactc caaatcccta ttgaaatacg 3526381 gacaaggaaa aacatcagtc cttgtgcgga agcacgatat tgcgtaggaa agatttcgct 3526441 ggcccataac tgatagttcg cttgctgccc ggctccgtta ttgatgccga tcacgacaat 3526501 aaacaggagc agaatcggca ggccttcaac tggcagcaga aacagtgtcc acccgatcac 3526561 cgccatgaaa gcggcgattc caaatacggt ttttctatat ttgtcggcaa agggcatgaa 3526621 gatcaaggcg acccccaatc ctgtgaagat aaacagcccc atttgcaaaa ggttggccat 3526681 gttggcagat acaccgccga cctgctgata aatgtatggc ataaagaagc ccatgacccc 3526741 ggcggctagg ttccaaacca agtacacacc catcaaaaac aggatgcttt ttagatacat 3526801 aggcttgagc aaatcaaaat acgatgtctt attcaataca gccggcttct ctgcctgagc 3526861 ttcctccggc tgattttttg tctgccaggc gtctgattcc ggaagcctga ttctcaggat 3526921 gtacgtaatc agcgcaatca caagcagatg ggcaaatacg attttattcc ccaagagtcc 3526981 caagtcaccg gccagtacgg agaggagcag tacaacgaca gcgcccgcgg cccaagcgac 3527041 ttgtgctacg ccgcaatgcc tggcccgatt cttctttggc gcattttccg caataatggt 3527101 ccatgacgcg gttatgtcag cccctactga taaaccgata atgatgtaac cgcttaacaa 3527161 catggggaaa ttaaccccga acaaaaccaa acaaatccct agtgcataaa ccagcatact 3527221 attggtataa acagccttcc gtccgacttt atcagccaga aacccgccaa gcagcgcgcc 3527281 gacagcggca gaaatcgcat ttgcgctcaa cgcgccgagc agcccgattt gcgtatcgga 3527341 tagcttaagg taactgaccc ataatgataa accggcggag cctgccacaa ttgaaccggc 3527401 atcaatatag ttggccaatg ctgccgcgat tgtccgttta ttgaaggctg aatctccatt 3527461 ggtattgccc atatgttcat tccccattaa gccagatcca acaactgctg atcaatatag 3527521 tttctcgcaa tcaatgcata ctccagcggg tttgcaacat cggggtcttg ttcagcttca 3527581 atgacaatcc atccggaata actgtgcttc aacagcagct gatatacttc tctaaagtca 3527641 atgcagccgt caccgggaac cgtaaacatg ccttttaaaa atgattgccg gaacgattgt 3527701 ccttcgagcc tgcattgttc catgacattc aggcgggcat ccttaaagtg cacatgctta 3527761 atgcggccga tatgcttctc aagcatcccc atgtaatcgc cgtcagaaat atacgcatgg 3527821 cctgtatcat agaggaggtg tacatgcgca gggtctgttc ctgccatcag gcggtccact 3527881 tcttccgctg tttggacacc agtgccgaga tgatgatgat agacaagctt caagccatgc 3527941 tgagcggcaa tttcgccaag gtgattcagc ccttcgcaaa gccgctccca ttcatcatcc 3528001 gtaaagtgcg gcttctctgt gaacacattt ttctccaagc tttgcacgct gtacgtttgt 3528061 tcagagacaa ctgcgacatc cgcgtttact tgctgcaaat actcacaatg cagggtaaat 3528121 gtctttgccg cttcaccaag tccgtcacgc aaaataaaac tgctgaacca ttttcctgca 3528181 atgcgtaagt tccgaagctt cagctctttg ttcaggatgg caggttcggg gaaaaagccc 3528241 ccgacctccg tgccttgaaa acgtgcgaca acgatatcac ttaacaaatg ctgaagtgta 3528301 tttcccgctc caatttcagg catgtcatca ttccgccacc caatgggagc gattccccac 3528361 aggatttcat ttttgcccat ctatggtgcc tcccctctaa tactgcttcg cagattccag 3528421 ctttttctct tttgcttcgt atgctttctg aacgctttct tgttcagata cctctgccac 3528481 cccgacatgc caccagctgt catagccgtc cgtcattgtt ttaggcagca ccttcatttc 3528541 aattaatgtt gatacatcct gtttcttcgc atcctctaac gcagctttta attcttctac 3528601 tgtgtttgca cggtaggttt tcgcgccgta tccctcagcg actttcgcgt aatcgacatt 3528661 caggatttgg ttgtcatctg tgcggaactc gcaatagtag ctgccgctgc cgtgatccat 3528721 ttgcaggttg ttgatgcatc cgaatcctga gttgtcaaag agcagcacat tgattttctt 3528781 gttgtactga atcgccgtga tcagttcaga atgaagcatc aggaagctgc cgtctccgac 3528841 gattgaatac acttctctgt cagggtgggc cagtttaaga ccgagtgtcc cggacacttc 3528901 atagcccatg caagaatatc catactccag gtgatacgta ttcggaacat tagaatgcca 3528961 cagacgctgc aaatctcctg ggagtgagcc tgctgaacag atgatgacgc tgtcttcagg 3529021 aatcgtctcg ttgattgtca gcaatgccgt tgtttgcgga agctccgtat tcaacgcgtc 3529081 agcatattca ttcaggacct cttgagaaaa gtgatttttg atttccggat caaatgcttc 3529141 ccgcttaaac gtcactttgc tgagacgctc gcgttcagct agccattcgt ccttcagctc 3529201 ccggatcgtt gtgccgaact cgctctcata gccttcaagc aagccgtgca gtttgccaag 3529261 cgtcactttc gcatccgcca ccacttggaa tgcatcaagt ttatacgcct gcattcggct 3529321 gacgttaatg ttcaaaaact tcgctttatc aaaatcaaaa gcggtcttag aggatgtcgc 3529381 aaaatctgta taccttgtgc cgatgccgat aatcaaatca gcttggcggg ccgctttgtt 3529441 tgccgcaagt gtacctgtga tgcccattcc gccaaggttg ttcgcaaaat ctgcctcaac 3529501 ggtagacttt cctgcctgcg tttcaactaa cggaatgtta taggcttcag aaatggcaac 3529561 caattcatcg cgcgcaccgg aatattttgc gcctccgccg acgagaatca caggtttttt 3529621 gctggattta atcagctccg ccgcaccttg aagctcgcgc tcgctcggct gcatgcgatc 3529681 aatatagtga acccgtttga cgaagaaact ttcatcaaaa tcgtatgctt ccccttcaac 3529741 atcctgagaa atacaaatcg ttgccggacc tgcttttgcc ggatcagtca tgacttcaaa 3529801 cgcgcgcagc aaactgctca tcagctgctc agggcgcgta atgcggtccc agtatctcga 3529861 tacaggcttc aatgcatcgt ttgtcgtaat cgccgcactg tattcttgct ccatttgctg 3529921 cagtacaggg tctggctgtc ttgtcgcaaa tgtgtctgcc ggaatcaaga gaactgggat 3529981 attatttgcc aatgcagtgc cggctgccgc caccaagtta gccgctccag gtccgacgga 3530041 tgtagacacc gcatatattt ttcttctcag catttgcttg ctgtacgcca tggccgcatg 3530101 cgccattcct tgttcatttt tcccttgata gactttcaaa tggcctgcat cctgctcaag 3530161 cgcctgcccg atccctaata cgtttccatg accgaaaatc gtgaagatcc cttcgacaaa 3530221 aggctcttcc tttccatcta catggatgta ctgctggttt aagaatttaa tcagcgcctg 3530281 cgcagttgtt aagcgaattt tcttacccac aaacgatccc acctttactc gatctttttc 3530341 aattatgact gtgcttcaat aagctgttcg atttcttccg cagtcggcat cgcttctgac 3530401 gaactgtgct tgctcaccac aatggaggct gaagcactgc cgtatttcaa tgccgtttca 3530461 atgtcttttc cgctgacaag gccatagata aaggctgacg cataggagtc accggcccca 3530521 aaggttttca gcacttttgt cttgtacgct tgagcgcgga atacctcgcc ggatttgctg 3530581 tatgcgtaag agccttcgac gccgtgtttg atgacaacga ggtcggctga atggccaaat 3530641 aaatgattga cggattcttc attgcttccg cctgtgcggt tttccatcac atcaaattca 3530701 tcgcgtgtgc cgatgacgat atcagactgc tcggcaacca aagaataata aacggctgtt 3530761 tcatctgatg actgccacgt atatggccgg taatccagtt cgaataccac cttaacctga 3530821 tgctttttcg cgtattgaac agcttttaac accgcttccc gtgacgggct tttggcgagc 3530881 gctgtcccgg agacaagcag cattttcgca tttgcgatat agtcctcact tacctctgaa 3530941 ggctcaagat aaagatccgc cacatcatcg cgatacatta agatgctgca ttcttcaggg 3531001 ctgaggattt ctgtaaatgc aaggcctgct ttgtgtccat cttgatcaac aatcatctgt 3531061 gtagtatcca cgccggtctt tctcatatag gactctatga atcttccatg ctggtcatcc 3531121 ggaattttgc cgatgaagcc cgcttttaag ccaagcttcg cgctgccgat cgcgatattc 3531181 gcaggtgaac cgccgacata tttcgaaaat gtcatcgttt cttccattgg gcggttgtat 3531241 tcgactgcgt tcagatcaat acatgcccgg ccgatggcaa caatatcaaa agccttctct 3531301 tcattgaatg tatacttcat cgtaaacagc cactcctcac ttgttagcgt tctaaaatcc 3531361 attcatgcgc cgggtcgtta taaaacttcc attttcgcgt cggccctgcc atgacattta 3531421 aatagtagga tgtgtatccg tccggaacgc ctaccgggtg gtatcccgca ggaacgatga 3531481 caacgttttc atttcccaca gtcattgtct cgtcaataga acggtcatct gtgtatacgc 3531541 gctgaaacac aaagccctgt cccgggtcta actcatggta gtacgtttct tctaagaaag 3531601 attcttccgg caagttgtct tggtcatgtt tgtgaggcgg gtagctggac cagttgccgc 3531661 tgtctgtata gacttcaact actaatagac tgttagctga agggtctgaa tccggaagaa 3531721 tgttatgaac agtacgtttg tttgaaaatt gcccgcgatg ctcaattccg ttgtcttccg 3531781 ctttgatcag ctttgtcgga agctgctttt ccgatggaga atagcaaagc gccactcttg 3531841 cgtcgctgac cgctgtgatc tcaaatgcac ggtcatttga aatatagacg ctgtctgtcg 3531901 gttttcgttc aaatacgctt tcgcgcgtgc cgatattctc aaaagtcgac tcatgatctg 3531961 tcactgtaat tttccccgtt accgccacaa tacagatttc ttgttttttc aattcttctg 3532021 tatagcttga acctgatgca agatctaaca ctttaaactc tacataagtg agatcagagt 3532081 tggatgtcgt tacttcgtgc acgagtttga ccccattaga cacttcatgc gactgcggct 3532141 tacgcaacaa ataactcata gagaagccct cctctttcta ttggcagaat gagtccgaac 3532201 agcgcacatg gacgccgttc ggctgttcgt cgtttagttg aaatcaggtg ccggatatct 3532261 tgccgtcacc acttttttac gtgtatagaa gtcgacgctg tcttttccgt tcgcatgcag 3532321 cgttccaaag aatgaagatt tccagcctga gaatgggaag aacgccattg gagccggcac 3532381 accaaggttg atgcctagca ttcccgcatc aatgttttca cggaagtagc ggattgcgtt 3532441 tgagttggat gtgaacaagc aggcgccgtt cgcaaactca gacttattgg cgatttcaat 3532501 cgcttctttc aggtttttca cacggatgac agataagacc ggagcgaaaa tttcatcttt 3532561 ccagatcgtc atttctgttg tgacattgtc aaagatcgtc gggccgacaa agtagccgtc 3532621 gtcagacaca ttttcacgtc cgtcacatac gagtctggca ccttcttcaa gacctttttc 3532681 gatatagctg agcgtgcgct tcttgttgtc ttcgcgaatc accggtccta agaacacgcc 3532741 gtcatcaagg ccgttaccga ttttaatgtc cgccactttt tcctgcagct tcgccataaa 3532801 ttcatcggcg attccttctt caactgtcac aaccgcacaa gccatgcagc gttcaccggc 3532861 agaaccgaag gcagctccaa cgatgtttgt aaccgtgtct tcaagattcg catcgttcaa 3532921 gacaatcgta tggtttttcg cgccagtcag agattgaacg cgttttaagt tttcgcttcc 3532981 ttttttgtag acgtattcgc ctactggctt ggagcctaca aatgaaatcg ctttaatttc 3533041 gggatgctcg aggatgccgt tcacaacgtc atgcgcaccg tatacgacgt tgaacacccc 3533101 tttcggaagg cccgcttttt caaaaagctc aaccaatttc tctgttaaca gcggagtccg 3533161 ctcagatggc tttaaaataa atgtgttgcc gagcgcgatc gccatcggga acatccagca 3533221 aggaaccatc atcgggaagt tgaatggcgc gattccgccg acaactccga ttgggtaacg 3533281 gtagttcgcc gcttcaacgt ccgttgcgat ggaagcaagt gagtcaccca tcatcaggga 3533341 aggtgctcca gcggcgaact ctacgttttc aatcccgcgt cccacttcac ctaaagcttc 3533401 tttcgtgttt tttccgtttt caatggtaat tagatgagca agttcttctt tatgctgaga 3533461 cagcagctgc tggaagttaa atagaattct ggcgcggcga ggaaccgcca cctttgacca 3533521 tgttttaaat gcttcagccg ctgtttgcgc tgcgtaatca atatcctctt ttgtagaaat 3533581 cggcacttgg catagcactt ctttcgtcgc cggattgacg acatcttcat attgatctgt 3533641 tttgctttca acccattcac cgttgatgta gttttttaat tttctgattt ctgccattct 3533701 tattgcctcc ttcattagta aacacataca cttgtatgga tggttccgga tagattcata 3533761 tcaatatcca cttttcagca agccaagaat taaacgcttt caaaaacacc aaaaaaataa 3533821 atggcggatg catatttaca tacaagcaac catttcatgc acaacaggtt actttttggt 3533881 catttcttgg ttatattcta atcgcataat acccataagt caatcataaa cactacattt 3533941 tttcattatt tttattatat taatctttta atcaagtaag agaagtaaga gaaggccgtc 3534001 caatcttgca aaagatatac accgatgtta tcatttttaa gcaactattg attaactttt 3534061 ggtttttatt atatatttat gttacgtaaa gattcaagaa ggagtttttt atatgaaact 3534121 gatgcggatt caggaaatgg aggagtacat tttatcgcat ggcactgttt ccttagatga 3534181 gctgtgccag gtgttcaatg tctccaaaaa cacagtcaga cgtgatatca acaagctaac 3534241 agaaaagggt gcgattgaaa aagtatacgg cggcgtaaca tctattgaaa aaaccgcatt 3534301 agttcctttt gaaaatcgca ccattcagca ccaggatgaa aaaacaaaaa tcgcccatta 3534361 tgcttcccga tttattgaag atcacgattt ggtcttcatt gattcaggaa cgacgacaaa 3534421 gtctattctt gatacgcttg atccagccaa aaatgtcacc atcttaacca acagtttaga 3534481 cattatcaat gcggcgtcag ctttgaagaa tatcaactta atcattatcg gaaacaacta 3534541 taagagaaaa acccgctcct ttgtcggcat ggacgacccg gctatgcttg ataagtacaa 3534601 tatcaacaaa gcctttatgt ccgctaccgg aacgacgctg actcacggat tgaccaattc 3534661 ggatctgctg gagtatgaaa ttaaaaagag gatttcagaa aaagcaaaag aagtgtatct 3534721 attggctgac cattctaaat tcggaaaatc aacgcttctg acgtatgcac cgtttgacag 3534781 gctgcattgc attgtgacct ctcagccatt agacgacgag tacacgcagt actgcaatga 3534841 gcatcaaatc ggcattcatc tggcctaacg tttacaatag tgttgagagt ctatcatcca 3534901 ttttattcta ggaggcagat catgaaaaaa gcgaagctcg gaaaatcaga cttgcaggta 3534961 ttccctatcg gattaggaac aaatgctgtc ggaggacata acctctaccc gaacctaaat 3535021 gaagaaaccg gaaaagaatt ggtgcgcgag gcgatccgta atggcgtgac aatgttagac 3535081 accgcttaca tttacgggat cggccgttcc gaagaattaa ttggtgaagt gctgcgtgaa 3535141 ttcaaccgtg aagatgttgt catcgcgaca aaagccgctc acagaaaaca aggcaatgac 3535201 tttgtctttg ataattcacc agattttctt aaaaaatcag ttgatgaaag cctgaagcgc 3535261 ttgaataccg attatattga tttgttctac attcacttcc ctgacgaaca tacgcctaag 3535321 gatgaagccg ttaacgcgct gaatgagatg aagaaagccg gaaaaatccg ttccatcggt 3535381 gtatccaact tctctttaga gcaattgaaa gaagcaaaca aagacggttt ggtagatgta 3535441 ttgcaaggcg aatacaacct gttaaaccgt gaagcggaaa aaacattctt cccgtatacg 3535501 aaggagcata atatttcatt tatcccttac ttccctctcg tatcaggttt attggcagga 3535561 aagtatacag aagatacaac gttcccagaa ggcgacctgc gaaacgaaca ggaacacttc 3535621 aagggtgagc gtttcaaaga aaatatcaga aaggtcaaca agcttgcgcc gattgccgaa 3535681 aaacacaacg tggatatccc tcacatcgta ttggcctggt atttagcaag accggaaatt 3535741 gatattttaa tcccaggagc aaaacgtgcc gatcagctga ttgataacat caaaacagct 3535801 gacgtgacgc tttctcaaga ggatatttca tttattgata agctgttcgc ataagaagaa 3535861 aacagccttc tccaatggag aaggctgttt ttttgtgcga taaattccta aataactgat 3535921 tttgaagcaa aaccttacaa aatgagccat aaatccgata aaataaaggt agtttatctc 3535981 agaaagaaag tgattgagaa agcaaaagta tgaaacgttc atatcatcta gctcatatga 3536041 aataaagctg acccagcttc ttttatttgc tggtcagaat agcggaccgt ttcgatggtc 3536101 tatggaggaa acagaatgaa acttaaatat gtaaaagcct tagttgcagt aaccgttgct 3536161 ttaggtgtac tgctgccatc aacgatttct catgcaaaga gctttagcgg ccgctcatca 3536221 tctagttaca gcagccgaag ttcaagctca tcatacagcg gaagctataa atcaagcccg 3536281 aaatcaagct acagctcagg atcaagctct tctagcaaaa aatccaagac gtctgacgat 3536341 tcatcatcat cgatttcgct taaaaagaag ccttcggaaa aggcaagttc atcaagctct 3536401 aaaaaatcgt caggcacctt ttccggcgct acatcaaaag taaccggaaa gacatacagc 3536461 ggaaaaacgt ctaaagccta tgttggcgga cgttatgttt cagtcaatca ttactatcac 3536521 gcaggtttcg cgccatcagg atggtttgga tattatagcg gatttacaat gggtatgttc 3536581 atgatcagca tgatgcaccc atggggttac acctatcatc cagtcggagg ccccggttat 3536641 gtttcttatg gcgcttcacc cattgcctgg atcgttgata tcatcgcttt gattattatt 3536701 ttaatcattg tcatcgcatt gattcgcgca tttaaagcac cgaagacgta cagaaggaga 3536761 ttttaggcaa tgagattaat attaaatgag caagaaattg tagacggaat ttgcgtgtat 3536821 atttccaatg aagaagatat ctaccctgaa gacgttgaag taaaagaact atcgtacaac 3536881 aagcgtacag ggttcttcgc tgaagctaca tttggcctgc accacaagca gcttatgtca 3536941 gatgacattt cagaaggcat tattcagttc ttagaggaat accacaactt caatccggac 3537001 gttaccgtcg ttgaattgca atttgataag aaaaaaggct tctccgcctt ggtttttgtc 3537061 aacgaagcag aagaataaaa atgtcttaat caaaccttac tccgcgcggg taaggttttt 3537121 ttaatggttt ctctgagcat aaagttattt cgtttttcct aaactcagcg gatctgtgat 3537181 catctctttt ggctataaag tttccgtttt ttcaaaacaa atgtttcaaa tgagatagga 3537241 aatgggtact aatctattaa ctttgttaca tatttttaga tactcattgg ctcaacaact 3537301 gaggaggaga catttgtgaa gaaagacaca aggaaatata tgatctactt tttcggcgct 3537361 ttagggggac tgctatatgg ttacgataca ggtgttatct ccggagcact cctgtttatc 3537421 aataacgata ttcctttaac gacattgaca gaaggattgg ttgtcagcat gctgctcctt 3537481 ggcgcgattt tcggttctgc cttgagcggc acatgctcag accgctgggg caggagaaag 3537541 gttgtatttg tcctttccat catttttatt atcggtgcgc tcgcttgcgc attttctcaa 3537601 acaatcggca tgctgattgc atctagggtg atactcgggt tggccgtcgg cggttcaacg 3537661 gcacttgtgc ccgtgtatct ttccgaaatg gcaccgacga aaattcgcgg gacactcggc 3537721 acaatgaaca acttaatgat tgtcaccggg attttgctcg cctatatcgt taactacctg 3537781 ttcacaccgt ttgaagcgtg gcgctggatg gtcggtctgg ctgcagtgcc tgccgtgctt 3537841 ctattaatcg gcatcgcctt catgccggaa tcgccaagat ggctcgtgaa gcgcggcagc 3537901 gaagaagaag cgagacgcat catgaacatc actcatgacc ccaaagacat cgaaatggaa 3537961 ttggcagaga tgaagcaagg ggaagcggag aaaaaagaaa cgacacttgg cgtgctgaaa 3538021 gccaagtgga ttcgccctat gcttctgatt ggcgtcggcc ttgccatttt ccagcaggca 3538081 gtcggcatta acacggtcat ctactacgcg ccaaccattt ttacgaaggc cggtcttggc 3538141 acatcagctt cggcgctcgg cacaatggga atcggcatcc tcaacgtcat catgtgtatc 3538201 actgccatga tcttaattga ccgtgtcggc cgcaaaaaac ttctgatctg gggaagtgtc 3538261 ggcatcacac tgagccttgc tgctttatca ggcgtgctcc tgacactggg gctttccgca 3538321 tcaacagcgt ggatgacagt agtctttctc ggtgtctata tcgtctttta ccaggcgaca 3538381 tggggtccgg tagtgtgggt gctcatgcct gagctcttcc cgtccaaagc acgcggagcc 3538441 gcgacagggt tcacgacttt ggtgttatcg gcggctaacc tgatcgtgtc gcttgtcttc 3538501 ccgctgatgc taagcgcgat gggcatcgca tgggtcttta tggttttctc agtcatttgt 3538561 cttctctcat ttttcttcgc gttctacatg gtaccggaaa ccaaagggaa aagcttggag 3538621 gaaattgaag caagcctgaa aaaacggttt aaaaagaaga aaagcaccca aaaccaagtg 3538681 ctgaatgagc gtacattata aaaaaaggaa tcgtctcctt atgagacgat tcctttttct 3538741 gtttacacca tgaccttgca aatattgttc gtaaattcca cagggtcctg aatcggcagg 3538801 ccttcgatga ggagcgcctg attgtacaga aggtttgtgt acaggctcag cttctcttta 3538861 tcttgttcaa acgcgtcctg cagtgtttgg aatacctcgt gatttgggtt gatttccagc 3538921 actttttccg ccttcacatt ttggctgtca ggcatcgcat ttaagatttt ttccatctca 3538981 attgtcactt cgccgtcagc agcaaggcag actggatgtg atttaagccg ttttgagatt 3539041 ctgacgtttt tcactttgtc tgacagaatg tttttcattt cctcaaacag atccttatac 3539101 ttgctttcct cttcctcgga ctgcttttga tcctcatccg tgtctatgcc aaggtctccg 3539161 cttgatacgg acttgaattc tttttcctga taagaagcca gcattttaat tgcaaactca 3539221 tcgatgtcct cagtaaagta gaggatttca tagcctttgt ccgccaccat ttccgtttgc 3539281 ggcagtttct caatgcggtc gtaagaatca ccggtcgcgt aataaatgaa tttctgctcc 3539341 tctggcattc tggaaacata ctcgtctaag ctgaccagtt ttttctcttt tgaagagtag 3539401 aataagagga gatccttcaa ttgatcctta ttcgcgccaa aatcattgta cacgccgaat 3539461 ttcagctgtc tgccgaacga cttgtagaac gtctcgtatt tctcgcggtc ttttttcaac 3539521 aggctttgca gctcgctttt gattttcttg ctgatgtttt tcgcgatcag cttcagctgg 3539581 cggtcatgct gcagcatttc tctggaaata ttcagcgaca gatcctcaga atcgaccatg 3539641 cccttcacaa agctgaagtg gtccggtagc aggtctgcgc acttattcat gatcagcacg 3539701 ccattggaat acagctccaa gcctttctca tattccttgg aatagtagtc aaacggcatg 3539761 ttttcaggga cgaatagaat cgcgttgtag cgaaccgctc catccacgct gatatgaacg 3539821 tgtgtcagcg gtttatcaaa cccgtaatgc ttttcagcat agaatttttc ataatcctca 3539881 tctgtcagct cgcttttgtt ttttctccag atcggcacca tgctgttgac cgtctgctct 3539941 tcctgcacct cttcaaattc attttcgctg ccttccttcg gcttattaat ggttgtatcc 3540001 attttgatcg ggtagcgaat gaagtcggag tacttcttga tgatcgcttt taaacgatat 3540061 tcctctaaaa actcgtcata gctgtcatct tctgtgttct ctttgatttt caggataatg 3540121 tctgtaccga cagaatcctt ttcacacggc tcaatcgtat agccgtctgc acccgcagac 3540181 tcccatttat aagcctcttc gctgccaagc gctttactga tgactgtcac gacatcggca 3540241 accataaatg ccgcgtaaaa accgacaccg aactgcccga taatgtcatg tccgtctttc 3540301 agctcgtttt cctttttaaa cgcgagggaa ccgctttttg caattgttcc aagatgctgt 3540361 tcaagctcat cctttgtcat tccgatcccc gtatcagaga tggttaatgt tctcgcatct 3540421 ttgtcagctg cgacctttat gtagtaactg tctttatcaa acgtaagcgc atcgtccgta 3540481 agcgctttgt aatagatttt gtcaatcgca tcactcgaat tggagattaa ctcgcgcagg 3540541 aaaatttctt tttgggtata aatggagtta atcatcatat ccagcaagcg tttagactct 3540601 gctttaaact cttttttcgc cactcttgat cgctccttta ccattatgta aacccttttc 3540661 agcatctatt tatcacataa gatgacaatt gtcaattaga ttgatagatg catatatatg 3540721 taaatttaac attagttgga tttgttttca ctctttttct cactcattct cataaaaaag 3540781 agaggcttca tcatcctctc tttttttctg tgtcattcca acggccaaac tcccgcttca 3540841 tccatatatg caccgggtag aaaaacaaac cgaacggtat caaaaacaaa agattatgcc 3540901 atgaagcatt cagaaatgcg cttgcagtca ccgggaacgt aatctcttgc aataaaaaag 3540961 agatgacagt cagcacaaca aatgcagatg gaatggtcac gatgcaataa aacttgagct 3541021 ccttcttatg ctgtaccttc aaacatacaa acctcccaac aatttctaat tcatcttaac 3541081 atatgctggc ctttcttttc tcgcatgttt atcactgcac atagcgggaa gacaaataga 3541141 aaaaggaggt ctcgtatcat gggaagactt gaaaacaaaa cagcagttat cacaggcgcc 3541201 gcgacaggca ttggtcaagc gacggcggag gtttttgcca atgaaggcgc gcgtgtgatc 3541261 atcggagata tcaataaaga tcaaatggaa gaaacagttg acgcaatcag aaaaaacgga 3541321 ggacaggccg aatcctttca cctcgatgtg tcagatgaaa acagtgtgaa agcatttgct 3541381 gatcaaatca aggatgcatg cggaacgatt gatattctgt ttaataatgc cggcgttgat 3541441 caggaaggcg gaaaggtgca cgaatatccg gttgacctgt ttgaccgcat tatcgccgtc 3541501 gacctgcgcg gcacattcct ttgcagcaaa tatttgattc cgctcatgct cgaaaatgga 3541561 ggctccatca tcaacacctc ctccatgtca ggccgtgccg cggaccttga ccgctccggc 3541621 tacaacgccg caaaaggcgg tatcaccaac ctgacaaagg caatggcaat cgactacgca 3541681 cgaaacggca tccgcgtcaa ttccatttca ccgggcacga tcgaaacacc gctgattgac 3541741 aaattagcag gcacaaaaga acaggaaatg ggcgaacaat tccgcgaagc caacaaatgg 3541801 atcacgccgc tcggacgtct tggccagccc aaagaaatgg caacagtggc actgttcctc 3541861 gcatcagacg acagctcata cgtcacagga gaagacatca ccgcagacgg cggcatcatg 3541921 gcgtacacat ggcctgggaa gatgctgatt gaggagaaat ggaaggaaga aacgaaataa 3541981 gagagggagc cccctctctt tttgtctttt aaagcaatac aaccttatat ttcttcacat 3542041 ccaaaaactg caaaaactcc ctcgccagca cttcaggcgg atgcgccttt ccttcatcca 3542101 gccgatacaa aagcaacccg ataatcattg cggatacata atgggcataa agctttttct 3542161 ctgcgtgaat atcagtttgc tgatgcagat aaaacgattc cagcgctttg aacatatcag 3542221 gtatcacatg aggaacaccc cattcccgat tgagaaaatg gacaatgggc atgtttgaca 3542281 aagcagaaag cagaatggcg agcgccttct ccgcttcctt taaggaaaat tcattcgggc 3542341 tggaggcaat cgtcaggtga tcaatgatct ccgcacatga tcgctgtatc atggtttgga 3542401 gcaattcctc cttattggca tagtgatcat aaaaggttgc acggcggata ttgcttttac 3542461 gcgtaatatc tgaaatcgtg atgcccgcgt agtcttgttt ctccgccaat acatccagaa 3542521 atgccttctg cagcgcctct ctcgttcgaa ccacccgcct gtcgatttgc ttctccttct 3542581 ctcgctctcc tggcacagct tttccaaaca gccaataaaa ccgcttttga gaaacaagct 3542641 cccatacctt ctggctgatg gcttcaggag acgcggccgc atcctcattc agccaataca 3542701 ggataatcgc gtacgtgtac aaggcccgat aatgtccata aatgtcccgt tcaatcggcg 3542761 ttaaattcac atggatcgga gccagcagca catcctgctg aaacacatcc ttaaaaaaac 3542821 gatgaaaatg tcctctgttc atcatcacag aaaaaaagga acgatgctca tgaacaaagg 3542881 acagcgtcgg atgcaccgtt tgccgttttt tgttcaaatg aagggtatcc atatgactga 3542941 aggcgtcaaa aagcgctttg cccagtcctt ccttcatgtc ttcgatcaca tcctcaatga 3543001 ttgaaaactt atcctcataa taaaggtaga gcgatccgcg gctcactttg gccttctcag 3543061 cgatttcttt cattgtgatg tgttgaatat ctctatcttt caataaagcc agcagcgcct 3543121 ctttcacttg agcttcggca gattccggca caaaagacac ctccaatcat tagacagatc 3543181 ttagatatat gtacggtaac gtatagatgg ttcaccgttg tctttcttac agaaaaggta 3543241 ccaccttata ataggtccga gaaaagaaga aagcaaatga gggggatttt acaatggaac 3543301 agcaagtaaa ggacgacatc cagcgtgtct ttcagcttca gaaaaaacag caaaaagcct 3543361 tgcgcgcttc aacagcggaa cagcggagag aaaagcttca acgcttttta gattccgtca 3543421 tcgcccatga agaagaaatc atcgaagcga tccgcaaaga cgtccgcaaa ccatatcacg 3543481 aagtcaaaaa agcggaaatc gaaggaacaa aaaaagcgat tagagataat atgaataacc 3543541 tggaacaatg gatggcgcct aaagaagtcg gttcatcgtt aagccctgac gcaaacggaa 3543601 ttcttatgta cgagcctaaa ggcgtcacac tcatcctcgg cccgtggaac tatccgttta 3543661 tgctgacgat ggcgccgctt gccgcttctc tcgcagccgg aaacagcgcg attgtgaagc 3543721 tgtccgattt cacgatgaac acgagcaaca ttgctgctaa agtaataaga gacgcttttg 3543781 atgaaaaaga agtcgcgatt tttgaaggag aggttgaggt ggcaaccgaa ctacttgatc 3543841 agccgttcga ccatattttc ttcactggaa gcacaaatgt cgggaaaatt gtcatgacag 3543901 cggctgccaa acacttggca tctgtcacac ttgagcttgg cggcaagagc ccgacgatca 3543961 ttgacagtga atacgatctg atggacgcag cgaaaaagat cgccgtcggg aaattcgtaa 3544021 acgccggcca aacctgcatc gcacctgatt acctgttcat taaaaaagac gttcaggaca 3544081 ggttcgcggg gattttacaa acagtcgtca acgctggatt tatggaggat gatcataccc 3544141 cagaccgcag caaatttacg cagatcgtca atgaccgcaa cttcaaccgc gtcaaagatc 3544201 tgttcgacga tgccatcgaa agaggggcgg aagtggtgtt cggcggcgta ttcgatgcca 3544261 gcgaccgcac gatctcgcca accgttttga aaaacgtcac gcctgacatg aaaatcatgc 3544321 aggaggaaat cttcgcatcg atcctgccaa tgatgaacta tgaagacatc gacgaggtca 3544381 tcgattacgt aaatgaccgc gataaaccgc ttgcacttta tgtgttcagc aaaaaccaag 3544441 atctgattga caacgtcctt cagcacacga catcaggaaa tgccgccatc aatgatgtcg 3544501 tcgtccattt cagtgacgtc aacctgccat tcggcggcgt caacacaagc ggaatcggct 3544561 cctatcatgg ggtatacgga ttcaaagagt tttctcatga gaagggtgta tttattcagg 3544621 ccgctgaata atcgcatgat caaaaggcgc ttccttagag gagcgccttt tattgtaact 3544681 ccttgaccaa aagcaattca tcacggatag gtattttatt atctgccagt aaaggaattt 3544741 cgggcttcat ctttctggcc gtctcgactg cattcacaaa tagtcgatcc aaccggtacc 3544801 ctctcttctg ataaaacgct aatgcatgaa tattatcatt ggttgtgatc agttttattt 3544861 gtttgatatt tctctctctg catgcttcct cggctttctc tagcagagct gttccgatcc 3544921 ctttattctc aatgacacta tccagcgaaa tgatttcaca ggcatcttct tcaaatatgt 3544981 atgtaataag gccaacaatc tggttatcat cgttgagcat tccataacca tctaattcat 3545041 cgcagttata aataccgcta gaaataacca tttgcggact gccccagtgt ttttgaaaaa 3545101 acgcggaaac aagatcttta ggtacctggc atgtcggaat aatattcata ttttcctcct 3545161 tttagctgaa caaaaataag agaattaaca acctatttta tgtcattaat ccccttatct 3545221 agtatttact agaacttata acttgtcaaa agctgtctga ataccaattg cgtggattga 3545281 taaggatcaa aatctgaatc ctgagattgg aagatttgct ctggggtcaa tgtctctgcg 3545341 ttctctgata acgtttgaat cagactttcc aaatatccat ttaactctga tttggacgat 3545401 tcatgtaggg attgatgatt tacagcgagt tctctaaatc tgttatcact gattaatttt 3545461 tttcgaagag ctgctagcat caagtcaagc catgcaggct ggccaaatgt aatatttaaa 3545521 gctaacgttg cttgatcaga tttggtggag tgccataaac ctcttggcaa atacagcatg 3545581 gttcccggtg ttaaattaac gatttctgca tctggcagat cctcttttgg cggatctcct 3545641 ttccaatatg actgtaaatc atcaggatag taaggagcct ctgataaatc atagtgctgc 3545701 attggattgc tcacattttc attcttggca agcttccatg ttttctcacc ttgaatttga 3545761 aaaatcaagt tggtgtaggc gtcaaaatgg gctttgaatc ccccgccatt tttcgccgcg 3545821 taaacaatgg ctttggaaga agtacccgca ggcagtctta attccgcttt gagtttttct 3545881 atccaccttc tgacttgggg aataaatagg tcggtgaaat caaactctaa tgcagcccct 3545941 ttttcatacc actctaaagc ctctgcaggt gacacaagaa atctgtctgt gatcccttca 3546001 gattcttcaa tcacagcatc accaacgacc atgactggat tattgtagat agccaatacg 3546061 ttttctagcg ttctaacctt ttcaaacccc ggtatgcttg taaatctctc cacttctcct 3546121 ctggctacca aaggttttac aggccaatat tcttctaaaa actcactcat cgttacagga 3546181 ctgatgatag actccaaaac cgattcggtt acagcactca tattatccct cccaaaaaaa 3546241 gtaacttcac cacaaagata taacattttt ttctaaaagt aaatattgac agaattatca 3546301 gaggattata atatttagtt gtgcgtgata gcctattttt ttacaaggaa ggagggaaaa 3546361 ggatgaaaaa ggcttataag aaacctcgtc tttttgaact gcgccgtgct gtagcagctg 3546421 gcggccatta atctcatata gcatttgaca tctagtactc tattttagga gggatgctca 3546481 atgaaaaaag cttataagaa acctcgcctt tttgaactgc gccgtgctgt agcagctggc 3546541 ggccattaat ctcatatagc atttgacatc tagtactcta ttttaggagg gatgctcaat 3546601 gaaaaaagct tataagaaac ctcgcctttt tgaattgcgc cgcgctgtag cagctggcgg 3546661 tcattaatct tatccaaaac gattaacgtt tgaggctatc acgccaactt gataaggagg 3546721 atgctgaaga tgattacggc tgaagaatgc agaacgtaca aagaatttgt tgatctttac 3546781 caatcctatc tttacccctt gcttggcgcc agactgtccc ggatgtattc ccccaaaaac 3546841 aaagtcatta tcgatatggg cacaggtcca ggttatttaa gcattcagtt ggctaaaaga 3546901 acaaatgcgc acgtgcatgc tgtcgatatt aacccggcca tgcatgaaat cgctcaagaa 3546961 gaagctaaaa aaagcggagt aagcagcctg atttcatttg atttggaaga tgtccaccat 3547021 ttatcttacg ctgaccaata tgctgacttc atcgtctcct actcttgcct gcatcattgg 3547081 gaagacgttg ttaaaggact taaagagtgc tatagagttc tggctccggg cggaaaaatt 3547141 gtcattttgg atacatttaa tccccaagga agccatttag agattatgcg aaaacaaatc 3547201 aaagaaccgg aatacttcag gtttgtaaga gaggcatttg aagaaagtta ttcctttgaa 3547261 gacattcacc agtttgttca ggatgccggc attcccaatt attcattaga aacctttcac 3547321 tttttaccgg aggattttat agaaagctta gatgagctgg aggatgctcc cctgtgggaa 3547381 caaaatgatc aaagtactga tcatgaaatt gagtctgtca catggatgtt aacgatagaa 3547441 aaagaaaagg aaggtgcatt gtaatgatca atgaatcaac tgttttatcc aaaaatccag 3547501 aaatgccatc aagaaaatat ttgaaaagca ttattataga gccgggcatc actttaaatg 3547561 aaatggcatc agatatttat aaccatatcg acggcaaggt cagcatacat gatatttgct 3547621 caaaaatcgt caatgaatat gatgttgatt atcaaacctg cttagaagat tgtatggagc 3547681 tgtttgagtt gcttattgat catgaagcaa tcaaagttaa gcagggggca tgagaattgg 3547741 aaaaacaaaa agtgcttgct ttaccagacg atgtacatga gctgagtaca caccgttcta 3547801 aatcaatcgt aaattacatc atcactctgc ttgcctttgc caaaaaacaa ggattgactc 3547861 atcaagatat tgtaagctgg attcacgagc aatatgagga aagaggatat tatgatgagt 3547921 ggagacacat taacagccaa caaccagttg gatcatttgt ggaactcttt ataaaaggaa 3547981 gacgtttact ttatgacaaa attgaattgt ttgaaacaga agataaatat gtcgtaaata 3548041 cccacacttg gtatgaaaaa gaacctagtg aggccttttt ttattttgaa attgatcccg 3548101 aagaattttc tgcgtacgct tccattctcg caatcgaaaa cgcaaaacgt ctcggaatta 3548161 aaatcgatat tgtaaaagaa acagatgtag agacagctta tatctataaa catcaataac 3548221 gctattggga gggagacata tgtgcgggct cgcgggtatt ataaatctgg ctgctccccg 3548281 ttctcaggaa tgtacctttc atatattgaa aggcatggca gatgccatca gctatagggg 3548341 accggatgat gaacaatatc atattgattc caaagtcggc tttgcatttc ggcgattgtc 3548401 cattcttgac cttgtaaatg gacagcagcc ctttttaaat gaggatggat caatcgtcgt 3548461 tatggtaaat ggagaaattt ataactataa agaactgaag gcttctttac acaatcatat 3548521 gtttaaaacg acatctgatt gtgaagtaat tgttcattta tatgaagaaa aagggattgg 3548581 atttgtagac gacatcatcg gaatgttttc aatagccatt tgggacaaaa ataaaaacaa 3548641 agtattttta gttcgtgacc gctttgggat taaaccgctt ttttacacag agctaaaaca 3548701 cgagcttata tttgcctctg aaataaaatc cctattttct catcctcact gtccccgcca 3548761 atttaattgg aaagaagcac tctcagacat ttggctaagc ggggaagcag ccagtaatca 3548821 taaagaaacc acttcctttt ttgtaaacat ccaaaatctc gatgctggcc attatctcga 3548881 aattaatttg acaacaaatg aacgaaaaac agcaagctat tggtctttac aggatatttt 3548941 gctcaggcaa ggctatcgtg agaatctcca tcccgatgac ctgattgaag gatatagaga 3549001 actgctggca gattcagtcc atagatgttt acaaagcgac gttgaagtcg ggttgtttct 3549061 tagcggtggc attgattcag ctgcagtcgc acattttgct gcagaaaaac aggatctcca 3549121 tacgtttaca gtattaagcc aaagtacatt tacaaatgaa gatgcaaaat atgcccattg 3549181 gctggctaaa gatttacacc ttccaaatca tcaggttctc tatcaattag ggaacgatga 3549241 gttattacaa ccagagtcat ataaacattt gttatggatc tgtgaaacac cgttttgcgg 3549301 accggaacaa ttatataagt ttcatttaca taagtatgcc aaagcgataa ggccaaacct 3549361 gaaagtcatg ctgaccggcc agggcagcga cgaatttaac ggcggttaca gcacgacact 3549421 ttcaccagcc gagaacccaa gttgggaagg atttattgaa tcggtcaata cgatggagat 3549481 gaaccggctg catcggctgc agggaaatat ctttagagtg tgggaggagc attttggact 3549541 ttctcctata aacctttctt atttaaagag caatgattcc agccaagcag atccttggca 3549601 atcgtatgtc ctgacaaaat accgtgatct gcaaatgtat aattgctggc atgaagatcg 3549661 gatcgccgcg gctaatcata tcgaaaaccg tgtaccgttc ttggaccatc ggcttgttga 3549721 atgggtttgc ggaatacctg atggactccg taaagacttg ttatgggata agtcggtatt 3549781 gcgaaaatca ttaacaaatg agctgcatac aagctatacc caccggccaa aggttccttt 3549841 tttctatggt aaggacgtga gatatacaca taaaatgatg tttcatcttc tgaagaaaaa 3549901 caattatcag cttatagagg aggccttctc tcacagcgat gcctccagca taatacaggt 3549961 tgaacacatt catgccatca tgacatattt ggaggatgat cctgagttta caaattttga 3550021 atttttatta agactggtga acatgggact tttatcaaaa atgactaaag aaaccccttc 3550081 tgttcaatta gacataacca gccatttaga atcgataaca ataaaagact ggcactcaca 3550141 ggaaggtgat attgccagtc gtttaaatat ctcagccaat aagtgtgaag gacaagatat 3550201 tttggcgcta aaccctggcg tcactctgtt aaggccggaa agcgatagtg agcattgcat 3550261 ctacattgcg gaagaaggat ttattcagtt tattgtttcg gaggaagacg tcggagcttg 3550321 gctgcatatt ctctgcgata ttaatggaaa agacacactt catacgattt tagacagaca 3550381 tggtgtcagc cttgaagaag tggccaaata tattcaagaa gccatcgaac acaatatcat 3550441 tttgatcaaa caaaaaaatc tgccagaagg agcatataga tgagcatctt ttattcgttt 3550501 tccgcactta ggggattagc aatggggatt ttttcgccta tttggattct ttatctgata 3550561 tctaaagatt atgatttcct tcagattgga ttaatgggag cggtacttga aattgctaag 3550621 cttatatttg aagttccttc cggcgttttt gctgatcgtt atggaattaa aatttcaatt 3550681 gccagttcat tctttttctc catccttaca tgggccttct tcccttttat cgattcagct 3550741 gctatttgca tactggctat gatcatatgg gctttatcag attccttaat ttccggttct 3550801 tttgaaactt ggatgagccg tgtcgcaggg gaagatcgat tcggcaaaga aatgatgaaa 3550861 aacacacaat tgctaatcac ttttttaatt attggaagta ttgccagcgg gtatttgtat 3550921 tcattaaata tctattttcc tttcctgctc gttatggtga tctacttatt actatttatt 3550981 tggatgtctg tatttattaa agtcccttct gtttccgaaa caaatcatgg ggatcagaac 3551041 caacatgatt cgataaagat tatcaaagaa agtttaaaaa ttatctttaa caaaaaaagg 3551101 gttcttttaa tcgtcatagc cggtttcttt acagccacag cctatgacac aatttcccgt 3551161 tactggcagc cttttttgag tgatttaggc ttttcagaaa agtcactggg atatattttt 3551221 gccctaggag ggtttaccgc tctcgttctt ttgacattaa ccatcaggtt cgaaaagaag 3551281 atcgaaaaaa atccatatct cgctttaacc tcattggatt ccatgggcat ggtcatgact 3551341 tttctattgt ctagagcatt caggccgctg ggcattccat gtacagcgtt tttgcttgca 3551401 attgaagata ttcatcatcc gatcgtaaca agttacttaa ataagttttt ccccgattca 3551461 tacaagaaca cacttttctc gttaaactca ggggtaggag caattggaga aattctttcc 3551521 ggtgtcattt tcggcatcat ttccgcagcc tttgggctct ctgccatgtt tgttgttgta 3551581 gctgtatttc tattaatccc tattatcctt tatacgatag tgcctaagat taaagacaat 3551641 gatatgaaag ttcagattga aaaatcccag caagtgtaaa tgttttgtat cacagtaaga 3551701 agaccttctt attaaaagaa ggtcttctgc tattctattc agttatttcc caaaagccat 3551761 cagcttcgta taacttccaa tataaagtgt tccgtcctca gcgagctgag gagaagacac 3551821 gacgttgctg tcggtttgat agctccataa ttcattgccg tttgcgtctg ccgcataaac 3551881 cttcatatca tctgacccga aataaaccgt tcccttcgcg tcaatcagcg gcgccgttct 3551941 gacagggccg tctgtgtaga atgaccagtt catatccccg tttttgctga tggaaaacag 3552001 ctcgccgctt cctgagccga tgtagatatt gccattatga tcaatcgcag gagatgagct 3552061 ggagaacccg tttagcggga atgtccattt caaactgcct gttgatgtat aagcatacag 3552121 ctgtccatct tggttgccgg cataaatgtt tccgtcctta tcaatcaccg gatatccttt 3552181 aaacgcattt gacgtcgttc tggaccattt cacctgtccg gttccggagt tgatcgcata 3552241 aaacacgtaa ttatatgtgc cgacatacac ggtgccgttt ttggcaagca ccggcacaga 3552301 gctgacgacc ccatttgttt tcaacttcca gcgctctgtc caggttgatt ttgacgtcgg 3552361 tttgatcgcg tgaacataat tatcaagtgt tgagaaatac aacgtcccgt ctgaaccgat 3552421 caccgtttca gagcttggcc cgccgcttaa cggaaccgtt gttaaaattt ctcccgtttc 3552481 tttgtcaata aaataaatct ttttgtcata ggatgccaaa tagataacgc cgttggtccc 3552541 aagtacagga gattgcgtat atgtttttcc aagattgccc gtcacccatt tgactgagcc 3552601 gtctggatta aaggctttca tttccccgtc tctggaatga agatatactg tgccgtctcc 3552661 gtcaatcaca gcccccgctc cattttgcgg agtcgttctg atgtcgtttt gccatttcag 3552721 cgtcccgtct gtatttccgg cgaaccggct ttcgcgtgac cagttaaaca tggcaggcgc 3552781 catcgcttgt acatcatatc ttcctggcaa aaagccagat gctccattat tttgagaaaa 3552841 caccgtttcc gccgcataag cagctgtcgg ctgaagcact ttggcagcgg gcacatcaga 3552901 aacagcgccg gccgaaacag ccgccgccac cgcagctccc gcaatcaaag ctttcatacg 3552961 aaatgacttg accatcattg agacccccat tatatgtaac ttctaatttg tgaccatcat 3553021 aacatattca tccattttat aaatctattt cacaaaaaca tcacaaacta gaaaactatg 3553081 taagagtatt cacggacgtt ttttcagcac ccgatcgaaa tgcagccaca aaccaaatga 3553141 cgttgacagc agccgcagcg agactaactc ccaaaacaaa gatcacctca gaaagcagat 3553201 ggtcactaaa gaaactaaac atcaagataa aaccggccga agacaaatga atcaaaagcc 3553261 cgaagccgca aagcaccgcc atgacatacc tcattgcatc gactccgagc atataaacga 3553321 gaaatggaat gaaatacaag acaaggatca taccgacagc tgaccacatg ccagctgaat 3553381 taaactgatt ggccgccgct cccgttccgg ccagcggcga aagtgaagcc gccacaatca 3553441 cggcgcaaaa aagaaacgca gaaatggttg tcatgatcgc cacgctattt ttttttgaca 3553501 tcaaactcct cctttaatag aaatattaac cttttttatt ataagtaagt tgaatgttat 3553561 attcattata tttttaaaaa attccagaat acatacacaa atgctatgct tctttctagt 3553621 atatttatat agtaaaaaac aaaggataaa agactcattt ttctgtaata tcaggatttt 3553681 atcaccatac catattgcat gtacatgttt ttcaaagtat actattccag attaattcag 3553741 aggagagaga aaaatacatg gaaaaaccag caggattttg gattcgtttt ttagcttatt 3553801 ttattgacgg cattattgta tctgttccta gttatattat tctatttatt atcaattctg 3553861 tgtttgtagc tggggctgtg gcaacaaacc cttacatgac ggaagaagag tatttagtga 3553921 aatacatgac gcttgcattt ttgcctacta tgctgatcat gatcgtcatc agcgtgttat 3553981 attacgggct gctcacagct tctaaaatgc aaggcacact tggcaaaaaa attcttggcc 3554041 tgaaagtggt caatgaacaa ggtgaacggg tttctgtcgg acagggaatt ggccgttact 3554101 ttgcctatat cttatctgga atcatctttt atatcgggtt tatcatgatc gcctttggag 3554161 agaaaaaagg cctgcatgac atcatttgca aaacacgtgt cgtgtataaa taatagaaaa 3554221 aagtctagac gccaataggc atctagactt ttgttttctt tgcaataggc tgccacgaca 3554281 gatacgtagc gcttctccac aaccactcaa acggccccat ccgaaagaca cgaagccaaa 3554341 ggtggctgaa gaccatttga acggcacaaa cagcaattgt aatgagcaca ccggcagcag 3554401 ggtacacttt tccatacagg cccaagccgt aatgataaaa aatccaagta cacacaatag 3554461 actgcatcaa ataattggta aatgccatcc tcccaacagc ggagaatgat tgcagcactg 3554521 ttctcactct tgttttatga taaagataga caaccgttgt aacatagaaa aacatgagga 3554581 aaggcgcgcc aatcagcaaa catatttctt tatccgttac actgtacagc acctgggcgc 3554641 cgatgccgat gacaagccca gccatccata atcgttttaa tcctttgcga tgcttttccg 3554701 gttcatgcaa ataccgtgat tttgctgccg cagctcccag caaaaacatg ctgaaatatg 3554761 gaatggatgc aaagaagtag ttgagcggat tatacgtaag catgccattc gaagacatgt 3554821 aaacaagacg gtcgtggatc cgctgttctg caatatcctt caggctgccg cttccataaa 3554881 catgaatcgc ttgttttgcc tgctgtgtta ccgcttgtac ccattcctgt ccgtttgatt 3554941 gatcaaaact tgtcaacatg aacggaatgg aaaacagaag atacaaagag accgcccata 3555001 tcagcagtgt tttcggcttt gcttttcgaa acaagagcag gacaaatccg agcagggcat 3555061 attctgttaa aatatccccg tcccatatca aaaaggcatg aatcgttcca aacaagagaa 3555121 gcgccattaa ccttctcaca tataacggaa caaaccgttt ccctttgttt tctgctctct 3555181 ccatcatgac aaccatgcca aatccaaata aaaaggaaaa caataaaata cattttgttt 3555241 gaatgaagaa tttcagtatg tctgcggcgg caaaatcagc ttcagaccac ttatccatga 3555301 aaaaattctc ttttccaagc atagacaaat acatatccgg ataactgaaa tgtgccagat 3555361 tgacaaataa gatgccgaaa atcgccattc ctctcagcac atcaagcaca ccgatccgct 3555421 catttgttaa agtcggctgt aatgaagaca tagccatcac gctccttttt tctgtacctt 3555481 aagggtagga aaaaatgaag cgcggtaaca tcgatttagg tgtcaggccg gcatgaaaac 3555541 cttacaatct tgtcatcttt atggtttcat cacctttaaa tctaatgctt cgatattctg 3555601 caaaatgcga tcaaagcgca aagcctgagg ctcacatggg aagatgtggc cttcatacgg 3555661 gtcgcctaac gtccggaaaa acggttcaaa taaaccagga accaatacgc ccaccatctt 3555721 tgtatagtga gaatcaaggc gataggagtg aacggtattt gcagggacat gcaggaaatc 3555781 tcccggattc agctgaattt cctggccatc tgtccacatc gtcatctggc cttcaaggca 3555841 ataaaatgtt tctgtatgat attcatggta gtgatcaacg attcggtcac ctttagggcc 3555901 ttcagatgat acgacgataa actggccatc tgtatttttt tgtgcagcca caatgcggtg 3555961 aagctgatct ccagtcaaca gacgatctcc ttctccagat tcaagaacgt atggaaccgc 3556021 tccatctggc agctctgtaa gttccgctaa tttggccgaa catgcaggct ttgcttcatc 3556081 tagaaataca atgtccgcta cagcggctgc ttctgcaaat cgctcgtttg agacttcttc 3556141 gcttgcgtac ggcggatgtt cagcgtgatc atacggattc ccaataacgg aatacaagtg 3556201 cgctacgttt cctttcatcg tgtaagacac cagtcttgtt ctgtggctct gcatccggta 3556261 gctgtgcggt gttcccgccg gaatgttggc ataatcacct gatattaata aatagcgttc 3556321 accatcaagt gtcagttcca gtttcccgtc caaaacgaga attccttcat gtgtgtcctt 3556381 gtggacgtga agcggaaagg catctccttt tcccccggaa agaagcacga tctcaaacaa 3556441 atcacctgtg ctcctcccat tcgccatcac cgtggcaacc tgtctgccga acagatagcg 3556501 ctcgccttct ccgctccgga gcaaataagg cattttttct ttaggcaatg aatgtgtaca 3556561 taatgttttc atattatcgc ttcctccaat ttagaccagt ctatatatta tcattcattt 3556621 gtctagaccg ttctatataa ttgtaggaga aaggataaca aaatgctacc ctttttttct 3556681 caccagcact ggtatttgtt cggcaatgag aagaagaggc gttttgtctt tattcgttaa 3556741 cgaaagcatg atgccgccct caatcatcga attaatcagc gttccaagct gatttgcttc 3556801 ttcttctgca aatccgtttt ccattaattt tctggcaaaa accgcttccc agcttttaaa 3556861 caccttcatg caaaccgtcc gcagcggttc actgattaac gctgtctcac tcgccagcaa 3556921 accgactgga atacctttaa tgctttctgt gttgtcaaat tggctggctg tttttttgat 3556981 aaaaagctga atcgcttcaa caggatcaga ggattcatcc atgctttgct gtatcagatg 3557041 ttcaacgatc ttacctgtat atgtaaccgc ttcaattgct agttcttctt tgccattcgg 3557101 aaaaaagtga taaagcgatc cttttggagc accgctttct tttacaatct ggttcaaacc 3557161 tgtcgcgtga tatccttgca gctggaacag acgtgacgcc gtgtgaagga ttttttcacg 3557221 tgaatctcct ctgctagtca ttaaaacatt ccctcctagg tatggtagag cgacttatat 3557281 aatataaaaa agaaccctgt gattgtcaaa aggggtaaga cccttccgga tggggtaatg 3557341 tacaaaaaca gcgtctagga gggatctctc aatgacaatc gatcattcag tcacaaatac 3557401 agagcagctt gaacaacaga accccgccat aaaaacaaag ctcaaactga aaaagcttaa 3557461 ggatcaggtg atcgtcatta ccggcgcttc aagcggtatc ggacttgtca cggcgagaat 3557521 ggcagctgaa aaaggcgcaa aggtcgtggc agcagcgcga aatgaagagg cgctgaagga 3557581 gctcactgat gaacttaagg aaaaagggca cgacgccata tgggtaaagg cggatgtcgg 3557641 aaaagaagag gacgtcaacc gcatcgcaga aaccgcgatc agcacattcg gccgctttga 3557701 tacatgggtc aacaatgcgg ccgtctcgac tttcggacac gccatggacg tcaccgtcga 3557761 agacatgaag cgcatgttcg acacaaattt ctggggacct gtttacggaa caagagcggc 3557821 tgtcaaacac tacaccggca gaggtgtgcc gggcgcactc attaatgtag gaagcctgtt 3557881 cggagacagg ggaacggtca ttcaatccac atatgcatct gccaaatttg cgcttcacgg 3557941 ctggacggaa agcatccgaa tggagcttga aaaggaacag gcgcccgtct cggtaacgct 3558001 catccacccg ggcagaattg acacaccata taacgagcat gcgcacagct acctcgacaa 3558061 acagccggct cattaccgct ccatgatcta tccgccggaa gcggtcgccg aagcgatcct 3558121 gtttgccgcc gaacacccta agcgcgacat gtacatcggc tcacaggcca aagccatcgc 3558181 catgctgggc gcgctttttc ctcgtctgac cgacagactg atggaaaaaa tcatgtatca 3558241 cagccagcat gccgaaagac cgtccaatcc gagagaagaa agcgctcttt atgatgctgg 3558301 ctgcggtatg catgacagag gcacaaataa aggatggatg aggtcaagaa gctactacac 3558361 aaaagcgacg aagcgcccaa ttgtatcggc ggctgttgtt gccggactag tggcttgggc 3558421 tgccgccaaa cgatgcagat aatctctgac cataagaaaa acccatgctg ttccagcgaa 3558481 ccatgggttt ttcagctgtt aatcgataaa agccttgttc atacgctgca gcagctcgcc 3558541 gaacatctct ttttcctgtg ttgaccattc tttcagcatc tgttcataac gttcaaggcg 3558601 cttttgctga tcggctttta atagttgttt gccgagtttt gtaatggtaa acaggctgac 3558661 tctcccatca gacgggtctg agaaacgata gatgagctcc tttgcctcta atgcagctgc 3558721 ttgtcttgaa agagtagaaa tatcaagctt aaacgattca gccaattcct taacacgagc 3558781 aggcccaaac tcatccaatt gtctcagtaa taagtacgaa gatctctcca aattccctgt 3558841 tcttttctcc gattgatcca gataaacagc tctcctgata aaagtcgtca gctcatattc 3558901 aattaattca actggatttt gattttgcaa tcgctctcgc tccctattcc aatctccggc 3558961 attgacaaca tcatatatac ttgtataata caaatgtaca ttaactgaat aaatacaagt 3559021 cgttatatga ctaaatcaat tattatactt gtatagtaca atcatataaa aagaaagtaa 3559081 agcgattcct cagaaccatc ctagaagcaa gcaccagaaa ggaggaagct gttctgattg 3559141 gagagcagca cttgatgtga aagtcatacg aattattttg caagtgttga tattatatgt 3559201 attttttatg atcggggaag ccattcagca tctgtttcat ttacccgtgt caggaagcat 3559261 cgttggattg gtattgcttc tgatctgctt gggcctccgt attgttcccg tctccatcat 3559321 tgaagacgga gcagggtttt tattatcctt ccttccattg ttgttcatcc cggcaatgac 3559381 aggagtgata aactatccgt ctctcatttc attcaatggc ctgatgctgc tgattacagt 3559441 cgttctcagc accatcgtca cgatcattgc ggctggattc gccagccagc tattagagaa 3559501 aaaagcaaaa aaacgggagg agaaagagaa atgcagcaag catgtatcgc gatcattata 3559561 attcttttaa cagttgccgc ttatttagcg atggtcaaac tctataagcg attcccgctt 3559621 ccatttctga tccctgttct gacaacgaca attttgattg tagcggcttt gatgatgttt 3559681 catgtttcct atgaaggcta tatgatcggg gggaaatgga tcaattcttt gcttgggccg 3559741 gctgttgtgg cgctggccta tccgctttat aagcaatggc atatcattgt caaacattgt 3559801 gttcccattt taggcggcgt cctggtcggc ttatgcatgg gaatgatcag cgggctgatc 3559861 ttcgcagaag cattcgggat tgatcatgat ctcttattat ccattctgcc aaaatcgatc 3559921 acaacccctg tcgctattca gatcgccgcc ggtcttggcg gcgtcccttc catgacagtc 3559981 gtatttgtca tgattgcggg cttttcaggc gtcatcctcg ggccgctttt cctaaaatgg 3560041 cttcgcatac gcagctccct aggacaaggc attgcattag gcagcgcctc ccatgcactg 3560101 ggtacctcca aagcgttgga atatggggaa ttggccgtat ccatgagttc cgtctccatg 3560161 acgctttgtg cggtgctcgg ctcattcttc ggcccgctcg tcgtctggct gtttcatatt 3560221 taacaaagaa agactgcccc gggggagggc agtctttttc gtttaagaag caaaaaaatc 3560281 aatcaacggc tgaaagtcct tagataaatc aacgtcattc ggttctgctt gaagcaggcg 3560341 gtcaatcata cgctccagct cctcaacatc attcttatcc gtatattcaa tgaagtttaa 3560401 gctttcaagc caatcccgat atgaatgttt ggctttgcca tagctgtttc caaagacaag 3560461 gcaaggtgtt ttggtgataa tcgagaaaat catcgcgtga aggcggtcgg taatcaccaa 3560521 tttactggag ccgatgcggt ccagcatctc cataaaatgc ttttcacgat cagcgtaatc 3560581 gatggtgtct accgtatcca gcaccgtatc ggtacgctct gtgtaagttg ttttttctgc 3560641 ccattgcttc atctgtgaaa taaaatcttc gtcagtcact ttctccttat ccgctcttaa 3560701 aataaagaga acgccgtccc gctcgagctc tcgcggcaca atatccaagg aaagcaccat 3560761 gtccggtgta aagatcacat tggagttgaa ggtctctttc acaacatcca gtgtttgcgt 3560821 ctcacgcgca gcaatcgtta agtttgtatt ttgatggtac gcatcctgtg tttttttctt 3560881 ttccttctgt ccttcctctg tatcctcaaa ataaacggat tgtggcagag aaattgattt 3560941 gtagtcttta aacgccgaaa agacctttct tctgtcttcc tcaatatcga gataaaggtt 3561001 tcctaaattc cctccgcctg taaagcagac aatatcgtct tcacgaatga tctccttcac 3561061 cagttcaatg ccctcatccg tcgcataatc cataatctca atgtattcat aatacggaaa 3561121 atgatttttg ataaatttct cttccgcata cgcaatcgct tggtcgccaa tgtttgtgta 3561181 gctaggggaa ccaaacaaaa atacttttcg tttatcattt aacagagctt ccggctccac 3561241 atttggcgca atgcctttta ctagtttttt gcctttgatt tcttgtacag tcatatctgc 3561301 gtcctccttc tgggatgaat tcctcattgt gtgttaactg tctctaccca aaaagaagga 3561361 tggctatgca ttggcatgtg catcggctat atcagaaaca tcgttttcgc caatttgata 3561421 gacgctgcaa tgtcccgcgc cgttctttcc atatattccg cggcatgttc aaacgcgtct 3561481 tctagtggca cggctccggg gacgatgctg aaaagcgcat cgattccgtg ttgatagacg 3561541 gcattactgt ctcgggaaat tgatcccgca atgccgataa cgggcacatc gtatgattta 3561601 gcggccttgg ccaccccgat cggtgttttt ccatgaaccg tttggctgtc gattcgtccc 3561661 tcgccggtaa tcacaaggtc tgcatcctga acgatacttt caaaatcaac cgcttcaagg 3561721 acaatatcaa tgcctctttt caggtcagcc tgaagataag ttagcaggct ccatccaaga 3561781 ccgcccgctg caccggcgcc ctctgtatct cggaaggttg atccgagcgc tttttctgcc 3561841 atatcagcga aatggcttac gttctggtct agtacatcca acatgtcggc cgtcgcgcct 3561901 ttttgcggcc cgaaaacagc cgtagcaccc tttggtcctg ttaacggatt gtccacgtca 3561961 caggcaactt ccagtttgac attccgcaat ctggaatcaa gcccgctcac atctattgat 3562021 gcaagctgag ataacgcgcc gccccctggg ccaatctcgc tgcctgagtt atcaagaagc 3562081 cttccgccca atgcctgaat catcccggct cccccgtcgt tcgtggcgct tccgccgatt 3562141 ccgatgatca atcgctccgc tcccgcatca agagctgctc cgattaattc tcccgttccc 3562201 cttgttgtag tgatgagcgg atttcgctta tctacaggca ccagatgcag ccctgaagca 3562261 gcagccattt caatcacagc tgttctccca tctcccatca tgccaaagaa agctctcacc 3562321 ggttccccca gcggccctgt gacaacttgc tctatgatcc ttccattggt cgcatcgacc 3562381 agagattgaa cggttccctc gccgccatcc gccaccggca attttctgta atcagcaccc 3562441 ggaaagaccg atttgaaacc tctttctatc gcttcggctg cctccagagc tgataagctt 3562501 tccttaaaag aatcaggtgc aatgatgatt ttcatccaaa tcgcctcttt caaaacatga 3562561 ttcacttaac ctattgatct ccaatgtacc ataattgatc tggaaataca taccatgcaa 3562621 tatggtaaaa atttaaataa aaattagaaa tgaaagtgtt tgcataaaag aaatattcac 3562681 gttatcatac ttgtatacaa gtatactcct tgagtgagga aggtgagtgt atgctagact 3562741 ccaaagacct gttgtatccc gcaaaatggc tctcaaaagc gtcaaccgga gttcgtgtcg 3562801 catacgagct gagaatgcgg atcgtttcag gtctgattga aagcggtacc attttatcag 3562861 aaaatacaat cgccgccgag ttttcagtaa gccgttcgcc ggttcgcgaa gcgctaaaaa 3562921 tactcgcatc cgaaaaaatc atccgcttag aacgaatggg agcggtcgta attggtttaa 3562981 ctgagaagaa aatcgcggaa atttatgatg tgcggttact attagaaaca tttgtctttg 3563041 aacggcttgt caaaatagac attgagcctt tagttaagga tctcagcaaa attcttgaaa 3563101 tgatgaaagt ctcaatcaaa tatgaggatg ctgacgaatt ttcatttcaa gatgtgctgt 3563161 tccatgaaac gattatccga gcgattgatc attcatacat tcagatgatc tggaacaatc 3563221 taaaacccgt catggaaagc tttattcttt tatcgatgcg ggtacggtta aaggaaaagt 3563281 atgaagactt cacaaggatt ttagataacc acgagcttta tattcaagcc atcaaaacaa 3563341 aggatagggc gctgatgatt cagtctcttc accaaaactt tgatgatgtg caggataagg 3563401 tagaagacct atggctctca caacaaatgc tggcaaaagg agctgaatac aacaatgact 3563461 agttatatgt taggaatcga tatcggcacg acaagcacaa aagctgtgct gttcagtgaa 3563521 aacggagatg tggtacagaa agaaagcatc ggctacccgc tctatacacc ggacatctca 3563581 acagctgaac aaaatccgga agagattttt caggcagtca tccatacaac agcgagaatt 3563641 acaaaacagc atcccgaaaa acggatctct ttcatttcgt tcagcagcgc catgcacagc 3563701 gtcattgcaa tcgacgaaaa tgacaagccg ctgacgccat gcattacatg ggccgacaac 3563761 agaagtgaag gctgggcgca taagatcaaa gaggaattga acggacatga ggtgtacaaa 3563821 cggacgggaa caccgattca tccgatggca ccgttaagta aaattgcctg gatcacgaat 3563881 gaaagaaaag aaatcgcttc caaggcaaaa aaatatatcg gcatcaaaga atacattttt 3563941 aaacagctgt tcaatgagta tgtcatcgat tactcattgg catcagcgac aggcatgatg 3564001 aacctgaagg gcttggattg ggacgaagag gcactgcgca tcgcaggcat cacgccggat 3564061 cacttatcca aactcgtgcc gacaaccgag atctttcagc actgcagccc ggaaatagcg 3564121 atccaaatgg gaatcgatcc ggaaacgcct tttgtcatcg gcgccagcga cggcgtgctg 3564181 tccaacctcg gcgtcaacgc cattaaaaag ggtgaaatcg ccgtcaccat cggtacaagc 3564241 ggtgccattc ggacgattat tgacaagccg caaaccgatg aaaaagggag aattttttgc 3564301 tatgccttga cggacaagca ttgggttatt gggggacctg tgaacaatgg gggcatcgtc 3564361 cttcgctgga tcagagacga gtttgcctcc tccgaaatcg aaacagcgac acggctgggc 3564421 attgatccat atgacgtgct gacgaaaatt gcccaacgcg tcagacccgg ttctgacggt 3564481 ctgctgttcc acccatatct cgccggagaa cgcgctccgt tgtggaatcc ggatgtacgc 3564541 ggctcatttt tcggcttgac catgtcgcat aagaaagagc atatgatacg cgcggcattg 3564601 gaaggcgtca tttacaacct gtacacggtg ttcttggcgt taactgaatg catggatggc 3564661 ccggtaaccc gcatccaagc gacagggggt tttgcaaggt cggaggtttg gcgccaaatg 3564721 atgtcggata tcttcgaatc agaggttgtc gttccggaaa gctacgaaag ctcatgtctc 3564781 ggcgcctgca ttttaggcct gtatgcaaca ggaaaaatcg attctttcga cgccgtgtcc 3564841 gatatgatcg gcagcacata cagacatacg ccgatcgaag actcagccaa ggaatacaga 3564901 acattaatgc cgattttcat caatctatca agattattag aaaatcaata tacacaaatt 3564961 gcagattatc agaggggctt aatcacacac aaatagtaca tgacatgaag gggagggcat 3565021 taccatgccg ttaatcatcg ttgcacttgg gatcttagca ttactatttc tgattatggg 3565081 cttaaaatta aacacattta tttccctgct ggtcgtatcg ttcggcgtgg cactggcact 3565141 cgggatgccg ttcgataaag ttgtcagctc catcgaagca ggaatagggg ggactcttgg 3565201 ccacatcgcg ctcatcttcg gactcggtgc gatgctgggc aaactgatcg cggattcagg 3565261 aggcgcacag cgcattgcga tgacgctcgt caacaaattc ggtgagaaaa atattcaatg 3565321 ggccgttgtc attgcctcat tcattattgg gattgcgtta ttttttgaag taggactggt 3565381 tctattaatt ccgattgtct ttgcgatttc aagagaattg aagatttcta ttttatttct 3565441 cggaatcccg atggtcgcgg cactatccgt cacacacggt ttcctgccgc cgcacccggg 3565501 acctacggcg atcgccggtg agtatggcgc aaacattgga gaagtgctgc tgtacggctt 3565561 tatcgttgct gttccgacag tgctcattgc agggccgtta tttacaaagt tcgcgaaaaa 3565621 aatcgttcct gcatcatttg cgaaaaacgg caatattgca tcactcggca cacaaaaaac 3565681 atttaacctt gaagaaacac ccggctttgg aatcagtgtc tttactgcaa tgctcccgat 3565741 tatcatcatg tcggtcgcga ccattatcga cctgcttcaa gaaacaatcg ggtttgcaga 3565801 taacggagtt ttagctttta tcagattgat tggaaacgca tcgactgcta tgattatttc 3565861 gttattggtc gcagtctata caatgggcat caagcgcaac attccagtca aaaccgtgat 3565921 ggattcttgt tcaactgcca tttcacaaat cggcatgatg cttttgatca tcggaggagg 3565981 cggcgccttc aaacaagtgc tgatcaacgg cggtgtcggc gattacgtag cagacttatt 3566041 caaaggaacg gcattatcgc caatcattct ggcatggctc atcgcagcga tcctgcgcat 3566101 ttctctagga tcggcgactg ttgccgcact aagcacaaca ggtctggtca ttccgttatt 3566161 gggccattct gatgttaacc tggcgttagt cgtactcgca acaggagccg gaagtgtcat 3566221 cgcttcacac gtcaatgacg ccggcttctg gatgttcaag gaatacttcg gattaagcat 3566281 gaaagaaaca ttcgccacat ggacattgct ggaaaccatt atttccgttg ctggactggg 3566341 attcatttta ttgttaagtt tagttgtatg aaattaagaa ggagctgtaa cacatgttca 3566401 attcgattgg tgtcataggc ttaggcgtaa tgggaagcaa catcgcctta aacatggcaa 3566461 ataaaggcga aaacgtcgct gtctataatt acaccagaga tttaacggac cagcttatcc 3566521 aaaagctgga tggacaatct ctcagcccgt attacgagct tgaggacttt gttcaatcgt 3566581 tagaaaaacc aagaaaaatc tttttgatgg tcacagcggg aaaacccgta gattccgtca 3566641 tccaatcatt aaagcctttg cttgaagaag gcgacgtcat catggacgga ggaaactccc 3566701 actatgaaga cacagaaaga agatatgacg agctgaagga aaaagggatc ggctacctgg 3566761 gagtcggcat ttccggcggt gaagtcggtg cgttaacagg gccttccatc atgccgggcg 3566821 gagatcgcga cgtctatgag aaagccgctc ctatcctgac gaaaatcgca gcccaagtcg 3566881 gagatgaccc ttgctgtgtc tatatcggac caaaaggggc agggcacttt acaaaaatgg 3566941 tgcacaacgg cattgaatat gccgacatgc agctgattgc agaagcttat acgtttctaa 3567001 gagaaacgct tcgtctgccg ctagatgaaa ttgcatctat ttttgaaaca tggaatcaag 3567061 gtgagctgaa aagctattta atagagatta cagctgagat tttacgcaaa aaagacgaaa 3567121 aaacaggaca gcctctgatc gatgtcatcc ttgataaaac cggccaaaaa ggcaccggaa 3567181 aatggacgag catgcaggcg attgataacg gcatcccgtc cacgatcatc acagagtcct 3567241 tgttcgcccg ctacttgtca tctttaaaag aagaacggat ggcagctcaa gatgtattag 3567301 caggcccgga agccgaagaa aaacacttgg ataaagacac ttggattgaa tacgtcagac 3567361 aggctcttta catggggaaa gtatgcgcct atgcacaagg ctttgcccaa tataagatgt 3567421 catctgagct ttacggctgg aatctgccgc tcaaagacat cgccttgatt ttccgaggcg 3567481 gctgcatcat ccgcgctgat ttcctaaacg tgatcagcga agcattcagt gagcagccaa 3567541 atctggctaa cctgctgatc gcgccttatt tcacagataa gctccatgcc tatcaaacag 3567601 gcctgcgaaa agtcgtttgc gagggtatca gcaccggaat ctctttccca tgcttaacta 3567661 ccgcgctctc ttattacgac ggctaccgca cagggcgttc caatgcgaac ctcttgcagg 3567721 cacagcgcga ttactttggc gctcacacgt acgaacggac tgatatggac ggcgtcttcc 3567781 atacgaattg gtctgaataa cctgtattaa aaacacggtc agtttcaact gaaccgtgtt 3567841 tttttcttct atcccaaaca acagaagaca taagttatgt tttaaatatc ataaacagtg 3567901 atacaataat agctagaaac aatccccaag atcatcatgt gacagcagat tgctgttccg 3567961 ttctattctg cttttggcca ttgtcctttg cccttgacca tggtgtcata aaatgttcaa 3568021 atgccaaaac ggcctggcat tctgatttac aaaagtccct gaaaacctta tctaattgag 3568081 aatcagcctc tcatttatta taaaagaaat gcctaaatcc tacctgtcac acctttatta 3568141 agatgaaaaa aagtaggtta tggcttgaca aaaaatatat attaattaat aattcatata 3568201 taattagaat tattattgaa agcgattatg ctttctaata catttttagg aggaatatac 3568261 attatgtctt taatcggtaa agaagtactt ccattcgaag caaaagcatt caaaaacggt 3568321 gaattcatcg atgtaacaaa cgaagatttg aaaggccaat ggagcgtatt ctgcttctac 3568381 ccagcagatt tctctttcgt atgcccaact gagcttgaag atcttcaaga acaatatgct 3568441 gcacttaaag aattaggtgt tgaagtatac tctgtttcta cagatactca cttcgtacac 3568501 aaaggctggc atgacagctc tgaaaaaatc agcaaaatca cttacgcaat gatcggtgac 3568561 ccatctcaaa cgatctctcg caacttcgat gttcttgacg aagaaactgg ccttgctgac 3568621 cgcggaacat tcatcatcga tccagacggc gttatccaaa ctgttgaaat caatgcaggc 3568681 ggtatcggcc gtgacgcaag caaccttgta aacaaagtaa aagcagctca atacgttcgt 3568741 caaaacccag gtgaagtttg cccggctaaa tgggaagaag gcggcgaaac tcttacacct 3568801 agccttgatc tagtaggtaa aatctaagga gtgcattcaa ttggtacttg atgcaaatat 3568861 caaagcacaa ttaaatcaat atatgcagct aattgagaat gacattgttc tcaaagttag 3568921 cgcaggcgaa gatgacactt ctaaggacat gctggctctc gttgatgagc tggcttccat 3568981 gtcatcgaaa atttcagttg aaaaagctga attaaacaga acgccgagct tcagtgtcaa 3569041 tcgtgtcgga gaagacactg gcgtgacttt cgccggtatc cctctgggcc acgaattcac 3569101 atcattagtg ttggcgttgc tccaagtgag cggcagaccg cctaaggtag accaaaaagt 3569161 cattgatcag gtgaagaaga tcagtggtga ataccacttc gaatcttata tcagcctgac 3569221 atgccacaac tgtcctgatg ttgtacaagc tttaaacatg atgagcgtgc tgaacccgaa 3569281 cattacgcac acgatgattg acggtgcagc atacaaagca gaagttgaaa gcaaaaacat 3569341 catggcagtg ccgaccgttt acctgaatgg cgaatccttc ggaagcggcc gtatgacgct 3569401 tgaagaaatt cttgcgaaaa tgggcagcgg cacagatgca tctgagtttg ctgacaaaga 3569461 gccgtttgac gttcttgtgg tcggaggcgg acctgctggt gcaagtgcag cgatctacac 3569521 tgcacgtaaa ggcatccgaa ctggtgttgt cgctgagcgc ttcggcggac aggttctcga 3569581 caccatgagc atcgaaaact tcatcagcgt caaagcgacg gaaggaccga agctagcggc 3569641 aagtcttgaa gagcatgtga aggaatatga tattgatgtc atgaaccttc agcgtgcgaa 3569701 acgccttgag aagaaagatc tgttcgaact tgaactcgaa aacggcgctg tcctgaaaag 3569761 taaaacagtg atcctttcaa caggtgcacg ctggcgcaat gtcaacgtcc ccggtgaaca 3569821 agagttcaaa aacaaaggtg tcgcatactg cccgcactgt gatgggccat tgtttgaagg 3569881 caaagacgtt gcggtaatcg gcggcggaaa ctctggtatc gaagcagcga ttgatcttgc 3569941 aggtattgtc aatcacgtta ctgtactaga attcgcgccg gaactgaaag cagacgaagt 3570001 cctgcaaaaa cgtctctaca gcctgcctaa cgttactgtc gtgaaaaacg cacaaacaaa 3570061 agaaatcaca ggtgatcaga gtgttaacgg catcacatat gtagaccgcg aaacaggcga 3570121 agaaaaacac gttgaacttc aaggtgtatt cgtccaaatc ggtctcgtgc caaacacaga 3570181 atggttagaa ggaacggttg aacgcaaccg catgggcgaa attattgtcg acaaacacgg 3570241 cgcaacaagc gtaccaggct tatttgctgc cggcgactgc acagacagtg cgtacaacca 3570301 aattattatt tctatgggat caggtgcaac tgccgccctc ggcgcgtttg attacctaat 3570361 ccgtaactaa tataagaaat ccgctatatt gccagattgg caggatagcg gatttttctt 3570421 tttctacaga aaaaaaccga accaggcact acggtaaaag tgctcgattc gagcgcttct 3570481 tatagttcct caccattcgt ttgaatgaca tttttatacc actcaaagga gtctttctta 3570541 tatcgtttca tggatccgtt tccttcattg tcacgatcaa catagatcat gccgtagcgt 3570601 tttttcattt cgccagttgt gaaggagaca atatcaataa tgccccacgg cgtgtagcca 3570661 attaaatcaa caccatcgta cgtgaccgct tttttcaatg cttcaatatg cgattttaaa 3570721 tattgaatgc gttccggatc atgaaccttg ccgtcctcct ccagcgtatc cactgcgcca 3570781 aagccatttt caacgatgaa taacgggatt tggtatcggt cataaaaacg atttaacgta 3570841 tatctcaacc cggttggatc aatcgcccat ccccagtcac tcgaagtgat gtacggattt 3570901 tcgacaccat tcggcaagcc gccatttaca atatcgccag tgttatcatt tttcacatcg 3570961 cttttcacag ttgttgacat gtaatagctg aagcctaagt aatcgacggt tccgtttctt 3571021 aaaatctcat catcgccgtc ttcgaatgtg atgttgtagc cttcgcgttc aaattccttc 3571081 aacgcgtagc ttggataata accgcgaacc tgcacatcag ggaagaaata gcgctgcctc 3571141 atttcttctt cagccagcat cacatcttca ggattggagg agaaaggata aatcggcacg 3571201 tgtgatacca tggccccaat ctggaactct ggattgatgt cttttccttt tgccactgct 3571261 aaggcgctcg ccactaattc atggtgcgcc gtttgataca tgacttcctt ggcgttttcg 3571321 ttttcgccaa ccacaacacc tgaattcgtc cataggaaca gcggattgtt cacatccatt 3571381 tggttgttaa tctcgttaaa tgtcatccag tacttcactt tatctttgta acgggtaaag 3571441 caagcctctg cgaagttgac gaagaagtcc acgactttcc ggtttctgaa gccgccatat 3571501 tctcttgcca ggtgcagcgg catttcaaag tgagacaggg taatgaccgg ctcgatccca 3571561 tgcttcagca attcatcaaa cacatcatca taaaactgca aaccagcttc gttcggttca 3571621 gcctcatcgc ctttcggaaa aatccggctc cagccgatgg acgtccgcag acattttaat 3571681 cccatttccg caaacaaagc gatatcttcc ttgtatctgt gatagaaatc aatggcttca 3571741 tggtttggat aaaattcgtt ttcttcaatc gtgtcagtga tttttctcgg cacgccgtgc 3571801 gcacccgctg tcatcacatc gacgacactc ggccctttac cgccttgatt ccatccgcct 3571861 tcaaattggt gggcagctaa agcaccgccc cataaaaaat cctttggcat gtttcccatg 3571921 tttaattcct cctcagctta cgactgtaaa tattttttga tgtaatgcac tttcctcaat 3571981 gtcttcaatg aaagctttat caaactcaac aagcacttcg ccttttttga cggtatcgcc 3572041 ttcttttacc ttcaaggaaa aaggcgtgcc gtcaaatgtc accgtatcca gcccgatgtg 3572101 cgcaagcaat tcgacgccgg acgctgaacg caggccaatc gcatgctttg taggcgtaac 3572161 catgacaacc gtaatgacgc cgggatggta gcatcgattt cacgatatcc ttcgctttag 3572221 gggtagaccg cttcagcacc aatcgaagtc tggtagcgca gcgagaagcc ccaatcacat 3572281 tctcttcccc gcctacggcc tctaaaatgt cttttgctag tctcgtataa tctctcactt 3572341 tccccgacat ttcacccacc ccttcgtttt ggttacgctt tcattataat tgtaacggta 3572401 taatttatca attccgaaac aaaatattta cgcactaact atcattgtaa gcggtttatg 3572461 ctataatttt gacaagtgaa actaaacgaa taaatgagga atgcgtatgt taaaatacca 3572521 gcaaatcgca acggaaattg aaacatatat agaagaacac cagcttcagc agggagacaa 3572581 actgccagtc ctagaaaccc tcatggccca gtttgaagtc agcaaaagca ccatcacaaa 3572641 gtccctcgag ctattagagc aaaaaggcgc gatctttcag gtcagaggaa gcggcatttt 3572701 cgtcagaaaa cataaacgaa aaggctatat cagccttctg tcgaatcagg gatttaaaaa 3572761 agatctcgag gatttcaacg tcacctcaaa agtcatcgaa ctggacgtga gaaagccaac 3572821 accggaagcg gcggaaaacc tgaacatcgg aatggacgag gacatctact atgtcaaaag 3572881 ggtccgctac atcaacggcc agaccctttg ctacgaagaa tcctattaca ccaaatccat 3572941 cgtgacgtat ttaaacaacg aaatcgtctc ccactccatc ttccattaca tccgggaagg 3573001 actggggttg aagattggtt tttctgattt gtttctgcac gtgggccagc ttaatgagga 3573061 agaagcggaa tatttgggat tagaggctgg actgccgaag ctgtatatag aaagtatttt 3573121 tcacctgaca aatgggcagc cgtttgatta ctcgaagatt tcgtataatt atgagcagtc 3573181 gcagtttgtg gtacaggcta atagtttttt attatagggc tcttcactac ggtaggtggt 3573241 cgacatgtac aaaattatca ttcctgccat actagccatc tttgcgctct ggatactctt 3573301 acagatttca ctagagatga gcatcgttaa gaatccaatg aactacttta tcgtattcat 3573361 tatctttttc ctctttgtaa agatggtgaa agaaaaacaa taatagtttg ggcgatgcaa 3573421 acagaaaaac atccttccct taacaaactc agccagtcac atgcattaat cttgatgtta 3573481 atgatatata ggtgcacata aaaagctact tcattgtgaa gtagctccct ttattaaagg 3573541 cccattttga tccatctagt tttagaaaag cgaaggacaa tcgcatttat gataataatt 3573601 gaaactaaat acaaaataat aaataaaaca tcattactcc caagtgtcat gttatcagat 3573661 tgcagcactc tttctattcg ggggtacata gtgttacctg cctcaaaagg agcaatgaaa 3573721 ccaaacgttt tattgcttat agctactaag ataacagaag tcatccaata aacgatactg 3573781 acacctatac taattaatat attaggacat aacacgctta tagttccgat aattagaata 3573841 tactgcagta taactgcaga aaataaaaaa agtaataatg caaaatgcga aaaatcatgg 3573901 tacatcaacg atatgattag caggcctagc gttataaatg caaaacattc taaaaataaa 3573961 acagctatct ttttataaaa gaaagtatag atgttctctc caattaactt gtaaaagaga 3574021 atatttttgt ttgaatactc tctattaata aagaaagcta taacaaatga aaataacatc 3574081 aaaccaaact gggtcgcaac agtataggag ctaaagaaaa acatttcagg tgtaacatta 3574141 ctgactttat cgattccaac aagtaaaaaa taacccagca aaaataaaaa tacaaacatt 3574201 gctcctaaaa taatgataac tttgttgcta atactctttt taaactctaa tttcatctca 3574261 agcccccact gttttattac tcatttatat acacttcaat taatttatcc actgaatgat 3574321 attgttgaat ttcttggtga ttaaatatat aataatcccc ttctatcgcc tttaaatcag 3574381 acaaatcatg tgtaatgttg atgataatct tctcggggtt ctcctgaata tacttgttta 3574441 agaagccatg aatctctata accgtttttt tgtctaatga attcgttatt tcatctaaaa 3574501 caataatatt tttatcctct aataagaaac tgagcaattt taatttttgc ttttgtccat 3574561 cactcaaatt tttgatcaga acttttccat caatattatc cagattaagt aaatatgcga 3574621 ttttatctat catttttgca tcaaattttt tactcaaaaa gtgtaataaa aagtccttag 3574681 aaacatcatt aggtatattc gacgagctgg atattaaaga aacattttga cgaatatctc 3574741 tgccgattct tttgctatta ttcaacaaaa agtctttagc aagctgtgat ttaccgactc 3574801 cattttttcc gacaacgtga ttaattttcc cgctcgaaaa atgcaagtcg gtgtcctgaa 3574861 gtaacgtttt gcctttcact tttaaagtgt aattcgctat attcatatac atactcctag 3574921 gaaatatttg cataataata aaatgttctg ccttgtgatt tgttactaat gtctaagctt 3574981 ttgaggtacc tctttcgttt ccgatccgga agcgaaagaa atgtttttag atggctaatt 3575041 tggagatctt ttactctagt ttacaatata taatatccaa tgtacaactg aattcactgc 3575101 aaggccaatc cctataattt gaatcgtaag aactaaccaa tgatttgtct taaaacggct 3575161 atattcatct aagctcagaa aagctaaaag aattttgtaa ccatcagaat tcaatattgg 3575221 gattaagttc cacaataaag tagacgagaa aagcataaat gccatagtta atgcttcact 3575281 ggaaaatgta aattgattta ttaattctaa tgtatttatt aaaagataat tgataaacaa 3575341 gccaaataaa tgaacgatta tcttttcatt tcttgatagc atgtaggttt cattcaattg 3575401 gacataaaaa gcaggaaata cataaaaatt cagtttgaat cccactttat caaagttttt 3575461 cccgaaaaat tttaaggaat aaatatgtcc cagttcatga agcactatat tcattataaa 3575521 ataaataact ataattatcc acattttcca gccgtaaaat actgaggaca atccattttg 3575581 caattttatt aaatgaatat aatttaatat gaacatgaga gccgtaaagg ataagaacag 3575641 ataaaaaaac tttggtgata ctttctcttt atacatttta aaacgtaata attgtttatc 3575701 tgacagagaa tttaaactat ttttatagta ttctccgctt tttttgtctt ttataaatac 3575761 gttgttttgc acaagcactt catatttttc atcttcatac tttaaaattt tcattatagt 3575821 atttttccat ataaggatag aagtagttta ttttttctgc agagttgaat aaggaaccac 3575881 aaactccaca aatagaggaa aattcataag gaatgtcaaa ttcctctatt ttgttatttt 3575941 cttttaaaat attcaaaaac catttgaatc cttcttttct aagaataaat aatagcaaat 3576001 tggaatttaa cttttccacg gttctttcga aactttggtt atattcttcc cttagggtta 3576061 ttttcgtttc aaaaatagca ggggaacaac atggataaat ttctccatca tgatgatata 3576121 caatgtcata tccgggacaa tgtaaggaat cttcatcttc aagactgtaa aatttatgta 3576181 tgttttcttg cttaattcta gttttagcag cgccaactga tatcattgga aattttgtta 3576241 tctttacacc taagattgaa tcccccaatt cctctaaaat gtggttggac attttgtctt 3576301 tggtaactgc catattaaga gaaatatcga tatcagggta tttcctgcta tgttctaata 3576361 tgtttttaat actggaagac ttgacaaatg gagcatggta ctcatcataa cttatagtca 3576421 gtgctatcac atttaaagaa ttcatatcat gaaagtactc ctggaccttt ttcttgctca 3576481 aaccccaaaa tccattagag atcaacgtta tttgtttttc atatggttta atgatttcca 3576541 ttagttcttt taaaaattta taatctaaaa aaacttcccc acctgtaaaa gaaatcactt 3576601 gaatggtttt gttttttgca aattcagtta ctaactctct tatgtattct ttttccatcc 3576661 tggttgttga agttggtgaa ctagaaaaac aacaatggtc acaggatgca ttacaccttg 3576721 aatctaaatt gattgatact gttttattat acatgaaata tcccccaaca aatggtaaag 3576781 gagagttaga ctctcctttg tacccctcta attaatgacc acttccaaga atccagcgat 3576841 tttcttttga ttttacaaaa taccaaagat cattcacttt tgctaacttt tgtgattcat 3576901 ctaatagacc cttaaattct aagtttttca cagtctcatt gttagtgatt tcctttttca 3576961 tattatccct cctccttttc taatataaac caattattct atatcattca atacatgtca 3577021 atatattgta cctaaaaaat ctgaaaaatg tcactattct tggtatataa agcctatagt 3577081 cctctagccc ctctaagcta taccgaatga aaggccatag tttgatttaa agcttcgtaa 3577141 tgaaaagtaa aacatcaata ttgactacac tagttaaggg atatacagat tttaagtgga 3577201 agaaatgagg caaacaatct taccctaaac caacctgtac tgaaaagctg ttttaagctc 3577261 ttgcttaccc catttggcac ctctttctct cgttttaatt gtctctaaaa gcagttatgc 3577321 ggtactatca tataaaggtc caatgtttaa aaataatgtc atacttttaa attcacctta 3577381 tcatgcacat gctcataaag aggggtttat tctaaaaagg ggatggacgg ttttggaaag 3577441 caagtaccta gatctactcg cacaaaaata cgattgtgaa gaaaaagtgg taacagaaat 3577501 catcaatttg aaagcgatat tgaacctgcc aaaaggcacc gagcattttg tcagtgatct 3577561 gcacggagag tatcaggcat tccagcacgt gttgcgcaat ggttcaggac gagtcaaaga 3577621 gaagatacgc gacatcttca gcggtgtcat ttacgataga gaaattgatg aattagcagc 3577681 attggtctat tatccggaag acaaactgaa attaatcaaa catgactttg atgcgaaaga 3577741 agcgttaaac gagtggtata aagaaacgat tcatcgaatg attaagctcg tttcatattg 3577801 ctcctctaag tatacccgct ccaaattacg caaagcactg cctgcccaat ttgcttatat 3577861 tacggaggag ctgttataca aaacagaaca agctggcaac aaggagcaat attactccga 3577921 aatcattgat cagatcattg aacttggcca agccgataag ctgatcaccg gccttgctta 3577981 cagcgttcag cgattggtgg tcgaccatct gcatgtggtc ggcgatattt atgaccgcgg 3578041 cccgcagccg gatagaatta tggaagaact gatcaactat cattctgtcg atattcagtg 3578101 gggaaatcac gatgtccttt ggatcggcgc ctattccggt tccaaagtgt gcctggccaa 3578161 tattatccgc atctgtgccc gctacgacaa cctggatatt attgaggacg tgtacggcat 3578221 caacctgaga ccgctgctga acctggccga aaaatattat gatgataatc cagcgttccg 3578281 tccaaaagca gacgaaaaca ggccagagga tgagattaag caaatcacaa aaatccatca 3578341 agcgattgcc atgatccaat tcaagcttga gagcccgatt atcaagagac ggccgaactt 3578401 taatatggaa gagcggctgt tattagagaa aatagactat gacaaaaatg aaatcacgct 3578461 gaacggaaaa acatatcaac tggaaaacac ctgctttgcg acgattaatc cggagcagcc 3578521 agatcagcta ttagaagaag aagcagaagt catagacaag ctgctattct ctgtccagca 3578581 ttccgaaaag ctgggccgcc atatgaattt tatgatgaaa aaaggcagcc tttatttaaa 3578641 atataacggc aacctgttga ttcacggctg tattccagtt gatgaaaacg gcaatatgga 3578701 aacgatgatg attgaggata aaccgtatgc gggccgtgag ctgctcgatg tatttgaacg 3578761 attcttgcgg gaagcctttg cccacccgga agaaaccgat gacctggcga cagatatggc 3578821 ttggtattta tggacaggcg aatactcctc cctcttcgga aaacgcgcca tgacgacatt 3578881 tgagcgctat ttcatcaaag agaaggaaac gcataaagag aagaaaaacc cgtattatta 3578941 tttacgagaa gacgaggcaa cctgccgaaa catcctggca gaattcggcc tcaatccaga 3579001 tcacggccat atcatcaacg gccatacacc tgtaaaagaa atcgaaggag aagacccaat 3579061 caaagcaaac ggaaaaatga tcgtcatcga cggcggcttc tccaaagcct accaatccac 3579121 aacaggcatc gccggctaca cgctgctata caactcctac ggcatgcagc tcgtcgccca 3579181 taaacacttc aattccaagg cagaagtcct aagcaccgga accgacgtct taacggtcaa 3579241 acgattagtg gacaaagagc ttgagcggaa gaaagtgaag gaaacgaatg tgggtgagga 3579301 attgttgcag gaagttgcga ttttagagag tttgcgggag tatcggtata tgaagtgagg 3579361 ggtgtggggt tcagggatgg tgatatgctg ctcccctaaa agtagataga tgaattttag 3579421 aaaatctgtt tgccttgggg agttttttca tggctggaca attatactac aaggaagaaa 3579481 tactaatact tatagaatgt aattgggtaa tgattcggag aaagaggttg cgaaataata 3579541 tggtattaca ctgaaacaat tatcaatgga gaacatgcac gatatagccg ttctatattc 3579601 tccctctatt atggcactca ttagtagaca taaccgtaaa aaaatgcact caaaaaaagt 3579661 ccattctata taactctcgc tagggtggac ctttttcaac attcaaagta ctagattttt 3579721 tctagtgaaa gaataagaaa agacataagt tctattttat cactctgtta taggttaagt 3579781 tattacggtg tttcattata tactgaattt aaacaccctt gacattatgg gaatttttaa 3579841 aacaggttaa aaggaagttc tataagaact ccctagttta atattatttg gtcaaaatct 3579901 aaaaccaaaa aatctatttt tatcttcatt gtttctatct aattttgcaa caatcatacc 3579961 tttcgactct aattcttgaa ggtcatctaa taataattca tttttattta ttgttacaaa 3580021 atattgtccg atcctattct ctaacagact tgaattgata tgttttaata atgtaccttt 3580081 tacatgagga tcaggattag aataagatcc gtcatgaatt aaaatattca aactacactt 3580141 atttatacac ctgtataaaa accaagtaag atcaaatata tttatcttca tatggagtct 3580201 accatgtgaa cgttcatccg gtatagaaca agaaattttg atccttcctg tagttgattg 3580261 ttttgcgtta cttattctat tatcatattc aaaatctaaa aatccatgtt ggttgtatgt 3580321 aacatccatt agattattaa aaagcttctt taactcacta actatagcgc tataagattg 3580381 aaactcatca taatacattg aattaactct taatatttca tgttgaagtt cattaatctt 3580441 atcaaaaata tggttttttt tatcgtagtc actaattctc aatcttactt ccgctaactc 3580501 tatttctttc cttctttgtt cttccatcac aatggaaata tcctcaatga aattgttact 3580561 ctttaaaatt ctggcacttg attccagttg ttctgttaat ccttgctttt tgatattaag 3580621 tttttttaaa tcggcttgta ttttaacaat tttatcttta aaataactcc ctctactttc 3580681 taccatgaaa ttatagaact cttggacttt attataattc tgttttactt cctctggaaa 3580741 aaaacctaca atatcttcat agaatttttc tatattttct aattctttaa tcttagttac 3580801 ttttttattt aaatcatcta tatttctttg atattgttta caaatatgtt cattttcaaa 3580861 tatttcattt tgtattttat taagttcact tttaatttct gagtacctat ttgtatcatt 3580921 attatattta ttggcagtct tagtttgata gataactcta ttgtaatcct ctatctcatt 3580981 tattaattca tcttccttaa cttttaaatc gccaatgtta atattcattg attcaatcaa 3581041 ttttatttca ctatttaatt tttcaatctt atcccgaaaa acctttatgt ttttttctgt 3581101 atgagttggt aaagtaaaaa gatagttaag taatttatat tgttttaacc ctcccctatt 3581161 cggtaaaact atatcattaa accctgtctt ttcgtctctt ataatatact cccttaacgc 3581221 cgcaaaagtt atatcctctt tctcaccctt taaaatttcc ttttcaataa attttttata 3581281 tacacttata ctaacttttt tccattcctc caaattaaaa gttaaagaag tatcatgtaa 3581341 tgtataacca tgtttaggag aattaaaaga tctagcaagg aatacttgat ttccatcaat 3581401 ttccacattc aaaacaataa aaacgttttt attgagaaga atttcatttg tcgtataaaa 3581461 atttgatata gtcttcccta gtaaaaagga gatgcattca atcatcgttg acttacctac 3581521 accattagtc tcttcatgat cttctctctt ttcaccaagt attatattta ctcctacagc 3581581 attaaattta tactctttca aaatttcttg ggaattgcaa acaaaaagat tttttataat 3581641 cataacaatc actaactctc cgttctgcta atcatatttt gattaaaaga aactttacct 3581701 aatgaatata aaaaagttaa cgataaatac agtatccgtt caatattcaa atttattata 3581761 ataccttgac tcttagcata atcaagaaaa agttgatcaa tatgtttttc cttctctaac 3581821 agttcataaa gtatctttga tgagtataaa atattttctt ccacagcatt atatttagtt 3581881 aataaaaaat gattcatttc tggcctctcc gccttttcct tttttaaagg agaattattc 3581941 actagaggaa taagatcatt tccaatttga atgtttttaa actcattttc taataaaaca 3582001 taagagtatt tgagaatatt ttcagctgtt tcaattttaa gatcaatcat tcttaacact 3582061 tcttttgtta tcattaaaaa tctcacattc ataaatgcac caacatgtta aaatcttaat 3582121 gtattttttc gttaaagcct ttgaatatgg taaaactgaa tgacattcta gataaatctc 3582181 attaacaatt tttacaaata tctcatctcc attattatat tgattatgaa actctagata 3582241 tttgtctact atcgtctcag caatcaattc ctttttatca gcacttacat acgaagtgga 3582301 atccattata tggtttatca caccaaaata ctcagaataa ctatcgaatt tccgtttaaa 3582361 agtttcccca cttttcatat cataaaattt tttatctaaa ccaatttgat tatcaaaatt 3582421 actagtaaat gttttataac tttctctata ctcatgaaaa tctataataa agctcttaaa 3582481 ctcatcttca tcaattttat catcgttatc ttctatttct ttttcaataa ggctctctaa 3582541 tctattaatc ttataattta acttcccttc ctgtagtctc cttcctcctt ggttgttttt 3582601 tgaccagtat ttatattcgg tattccaaat gtagtatgtt acttctgtct cgccattatc 3582661 taaattcaca tccaccgaaa taaattctgg agtagcatac tcatccttta taatggctcc 3582721 acttactaat tctaagaatg gattttcatt tgtatttgca gtaatattaa atgaagaatc 3582781 atgtacatgt cctgccaaat atagatcaat aaagtaatca tcaaaatgtg cctttattga 3582841 ttctctttcg gaagattcaa tacaacctaa cgtatggtgc ccaatagcta tatttaatac 3582901 cttgccctta tttttctctt tgttcatctt ccttattgct ttatataatt tcatctgtgc 3582961 agttaataac gttccttctt cacctttttt atctgataac agacatgtat ttattgataa 3583021 aacattatac ttctccgatt gatacaaaaa atgcaaatct tcttccggat atttaacacc 3583081 cataaaatct tcataaaaat cgaaaaattt cctttgacct tccactaata tatttgtagc 3583141 tttttgatct agtttatcca acatttctga ggggttagga gatttcataa tactatcaat 3583201 caaaagtgtc ctcgtcatgt ctctagatat atcgtgattt cctggcacta agtgtacgtt 3583261 attcttactt aatcccatac ttttaataat tccattaaga tattctttaa catcttcgtt 3583321 atacacatca cctttgtgtg ctatatctcc agttaataat aaaaaatcaa aatctgactc 3583381 tcttcttaaa acttctataa aatctaataa tttatctctc attacaatag tgtcataatt 3583441 ttgaaactga aaatgcaaat cagaaatttg taaaaaacgt accttcaata caaacatcct 3583501 ctcataagta tatttatccc ctatatattt ctagaaaact ttttattcta tatcatcttt 3583561 actctttaat atattaagac tctttccaca ccatcaaata aattataacc taaacataac 3583621 tctttactca ttttagtatt gtatttaagt caaacattgc attggttgct gaaatattat 3583681 attcattgaa ttattccatt aaatagcttt tagttgaact ttagtctttc tgtaatggtg 3583741 gagatgctct tacttatgat aaggctcccc acgattaatc cgaaaagccc gataaatctg 3583801 ctccactaaa ataagccgca tcaactgatg aggaaatgtc atcttcgaga acgatagctt 3583861 ctcgtccgct cgcttcatca ccgtgtcact caatccgagt gatccgccga tgacgaaggt 3583921 gactttgctt tttccataag tagccagctt atctattgta tcggctagtt cttcggatgt 3583981 tttcattttt ccttcgatgg cgagggcgat gacgtgggcg tcggggctga ttttggatag 3584041 gatgcggtcg ccttctttgt cttttatgat tttcatgtcc tggtcgctta ggttttccgg 3584101 cgctttttcg tccgggagtt cgatgatgtc gatttttgcg taggccgaaa gtcgtttggt 3584161 gtattcttca atgccttgct tgaggtattt ttcttttagt tttccgattg tcacaatatt 3584221 gatattcaca ggtcatcccc actttaaaaa caagttattc atatatgttg tccacaattg 3584281 tggatatctt ttctgtattt tgtgtaagat cattcgttcc ccactatata tactgcgggg 3584341 tctccacata attcacaggc tgtggataaa ctgttagtat gttcgatttt tctgatttcg 3584401 ggcggcagct cgtggtcgtc tatgtacata tccagcaccg tttcgatgtg ttcttcacaa 3584461 gaataatacg cttgtttcat gttcaaatcc tccgatgttt tcttccattt ttacaaatgt 3584521 tctcttctca atataaccta tttattcaca tgttagtagt gcttcgggct gagttttatc 3584581 cacaattcga caaacaagct gttgatgact ctatttcgct cgtgtgttag tttggatgta 3584641 accgatgtgt ggggaggtct gcatttgcgc tttagatggg tttggctttt tgtgattatg 3584701 ttgctgcttg ctgagtgtca gccatcttat tgggtgttgg agaaggatcg aatcggtgaa 3584761 ggcagtccag acttagaaat atacgctaat tatctccaaa tgcatgatga cgtgaaagga 3584821 tatcaagtct tcaccatatc agaaggcaaa aaaatggtcg tcgtgtctct cggaagcagc 3584881 gagaaagata agaagcttga agtgtcggac gtcaaattct catctaaaga aacgattgta 3584941 actgtggagc gaaaacctgc tcctacggca aatgagaaaa acccttttat tttgattgga 3585001 ctggacaaaa ttgaagggga tttaattgtt caagacgaaa caggagatcg ctttgaagaa 3585061 acggattacc agcaataaag ccggcgttct gagaacgtcc ggctttttct tttacttcaa 3585121 tgtcccatgc gggtcgatga cgaatttttt ggctgcgcct ttgtcgaagt cgctgtagcc 3585181 ttttggcgcg tcgtccagag aaataacggt ggcattgacg gcttttgcga tctgcgctct 3585241 gccgctcagg atcgctttca tcaaattgcg gttgtatgtc atggcgggcg tttgtccggt 3585301 gacgaaggtg tgggctttgg cccagccgag tccgaagcgg atttttaatg agcctgtttt 3585361 ggcgtccgca tcctttgcac cgggatcttc ggtcacgtat aagcctggaa tgccaaggct 3585421 gcctccgacc tgggtgacgt ccatgattga gttcagcacg gcggctggcg cttctccttg 3585481 attgccgtgc ccagatgctt caaagccgac acagtccact gcagcatcaa cggttggttc 3585541 acctagtatt tgttcaattt gctcgccgag gcggtcgtgt ttttgcacgt tgaccgtttc 3585601 acagccgaag cttctggcct gtgccagcct gtcttcgttc agatcgccga caatcacggt 3585661 agaggcgcct aggagctgag cggagtgtgc agctgccaag ccgacaggac ccgctccagc 3585721 gatataaacg gttgaacctg tttgcacgcc cgctgtataa gctccatgga agccggtcgg 3585781 aaaaatgtcg gacagcatgg tcaaatcgag aatcttttct agcgcctgtt ctttatcagg 3585841 gaataccaaa agctgaaaat cagcgtatgg caccatgaca tattcagact ggccgccgac 3585901 ccagccgccc atatcgacgt agccgtaagc cgatcccggc cggtccggat tgacattcag 3585961 gcacacatgc gttttctgcg ttttgcacat cacacagcgt ccgcaggcaa tattgaaagg 3586021 aacggatacg atatctcctt ttttgataaa ttcaacatca cgccccgttt caatgacttc 3586081 tcccgtaatt tcatgcccga gcaccaagcc ttctggcgcc gttgtgcggc ctctgaccat 3586141 atgctggtcg cttccgcaaa tgttggttgt aatgactttg agaataaccc catgctcaca 3586201 ttttcgattc acattcgcct tcgggacgcc gggcccgtcc ctcaagatta actccggata 3586261 accgatatcc tccaccgcta cagtcccttt gcctttgtac acaaccgctt tgtttcctgt 3586321 caacgccatt cctcccattc atgtgtttgg actctccgtc cttgaacatg acttcggttc 3586381 ggcatgactc tttccctttt tcacgactgt tttttctgta ttcttacaac aacaaatatg 3586441 ccaagaaagc atccaataat ggttccgccg atgtctaaga agtcgacttt acatccattt 3586501 aacaagaaca cagtaatggc cgaaaccagg cagatcataa ctgccagaag aataacccga 3586561 tttgtctgca tgtaattcct cctttggatt cgtttctaaa ccatacccaa aatcctctgc 3586621 aaacttcggt tcaacaaaaa aagagacttc acaccagtct cttcataaac agagatcact 3586681 caaaaaattt cctgagaaat aatgtggcaa cactcgttac taacgcaatt gccgtataca 3586741 taacaaccca aaatatgaat gagctattcc ccgaagctaa cgtaactaac aatatcaagc 3586801 tcgtgataag aacgatgagc ggtgccaccc aaaatctttt aaataaaaaa tgacccgcta 3586861 taccaaatac acctgcgacg atcggaaaac caaaaacgat aaataaaacg gcgatggctc 3586921 ccatactacc ctccttgcct taaaacctct tcatcacctc aacatcatac agcttcaaat 3586981 gactcttcgg cgtcacgaca tcctttacct tcccaatctc tttttctttc attttctttc 3587041 cggttttcag gctgtactgt tcaatgtagg caggcttgtg atacgtgtat gtgaagaaat 3587101 agaggctgct gcctttttgg gtgatttctt tgaattcggc tttcattttg tccggggaaa 3587161 gggtgaagac gatgcttgtt tttcctgtct tggcatcgat tttgtgtacc tttccgaagc 3587221 cgtcaatgaa atacaggttc ccgtcataag ggaaaaagct gtttttaaag ctgaagggca 3587281 tggagctgta tatcgtttgt tcgtcgtttt tgtattcggc gatatcgtgc agctctactt 3587341 cgccgctttt tttgttgatc ttgaccattt gatagagatc gtgggctttt tggccgcgaa 3587401 ccataacata cacagcttgg tcgtccacgg caagttggga ttcgactgag gctccttccc 3587461 ggtactgcca ttccgttatg ctgagatagg taagcttctt ctgatctgct tgaatctgaa 3587521 ggagctgata gccttttccg tcatctgtcg ggacgagtgc gtaaatggcg ccatcatgga 3587581 aaccggaggc tcggatgtag taggggatga cgtctttttt ccactctccg tccatttggc 3587641 ggtacagctc tgagcggtat ccgtctccct ttttgtcgta gccggagttg tataaggtgt 3587701 aaaagccgtc cgtgttttgc agaaagcccg cgctgtcgcc tgtgtgctga taggttcttt 3587761 tatgggagcg caggccgttt ttgatcgtat aaatcgtgtt tttgtcctcc agcatcacgc 3587821 tgtcaccgtg aacctttgct gagcccagct caaggccctt catctgaaag gaagacagcg 3587881 tcccgtcatg gctgataaac agggcgtagc ttttcccgcc gccaaatgca tcttgatccg 3587941 cagaggatga gaaatacagc aggacttctt tgtcatccag gaaatcggga tttctgagat 3588001 cctgctgact cacggtttta tggcttttga gaggagaaat gaagacaaat agtgcgattc 3588061 ctgcgagaat cagcatggcg atggtaatca tccacttttt catagccttc tccttagtaa 3588121 atggtcataa tggttgtcgt ataagaagaa ctagtgatgt cgcgcggata cacgcctaag 3588181 cctccgttgc tgtctatatc aatccctgct ttcagcaaaa aggcagacca taggagcttt 3588241 gaacagtttt tggcgccgtc atggccggta tttctgttat tgacgaagtt aaatgagtat 3588301 gggtcgccga cttttgatac cgcccagtcg gcagcagctg ttttttgaga tgaggatacg 3588361 ctgacggttt gcacaatgga gttgtcttcc acgtctctgg cattatacgc gatctgcctg 3588421 acgccgtcgc tcgggacaga ttcaacaatt ttgtcagcgg cggagtacat gccgacatgg 3588481 ccgtgattgt agtaggctgt gtaggagttc gtgtaataga tattgccttt cgcgcttgtc 3588541 gggagttttt tcgtgccgga cgagccgccc atgatagaca tgccgctttc cttggcgagc 3588601 cggtccccct ctgctttatc agccgtgatc tccttataga actgttttag gataacgtcc 3588661 tgctttacgt gctgctgttt ggcaatctgg ctggcagatt tcatgatttc ttccggtgtc 3588721 gtgcctggct gcagtgcggc gatttcttca gcataatttg tggtctttac ggctttggcg 3588781 ggagtaacaa acaggccgcc gcacattgtg agcgctacca aaaacatcga cactcgtttc 3588841 ttcaacttca ttacatctcc tcttttcttg tgagtgtagg aaaggtaatt tcctcaccca 3588901 cattatatta ggaaaataag gaaagtaact aggttattta cagaattttt agaaatcgtt 3588961 tacagaaaaa ggcctttatc aggccctttt cgttaaagct tcttgctcat cactacgtct 3589021 gtttcttgaa atccggtttg ctcatatagc tttcgagccg tctgattatg ggcaaagaca 3589081 tgaagggaca gcttgcggat tcccatactg cgtgccgctt gatctaatgc cgccaatgct 3589141 tgctttgcgt agccctttcc ccgatacggt tcatataacc cgaaatcata aataaacgct 3589201 tcctgctgcg gatgctccgg ttcagcatgt atccagagcc agccaacgat atccttttca 3589261 ttcagcttga ggctccacaa atggtgatgg ggtgtttcga gccctctcgg aagcagatca 3589321 gtaaacacct gcttagacaa aagctgggca tcttcaggca gccatgttcc cgcttttacc 3589381 ttttcttccg cgtaatgctt tgttgtgtac gtgagataag accgaaattc ttctgtctgc 3589441 ataggggtta gcataattgt catatcatct ctccttcata tattgactag aggattttac 3589501 ataaaataga aagaggtgtt actatcagaa taagcaactg agattgataa gtcactagag 3589561 aaaggagttt cacatgaata agatcgcacc cgcagaaatc gctagcatgc tcaacgattg 3589621 gtaccttgcc atcaagaaac atgaagttga agaatcctcc cgtttatttg aagaagtgaa 3589681 gcctttattg gatgacatgg aagaggatca ggaggtgctt gcctacttct ccttattgga 3589741 actgcgccac aaggttttgc ttcacgaggc gagaggacag ggctttcagc atgaggagcc 3589801 ttctcatatg aatgctacgt ctgacatgct gaaatattac ttttttctgt ttgaaggcat 3589861 gtatgaggcc tataaaaata attatgacat tgccattggg ctgtataaag atgcagagca 3589921 gtatctcgac aacattcccg atccgattga aaaagccgaa tttcacctga aggtcggtaa 3589981 gctctattat aagctgggac aaaatattgt gtccctcaat catacacggc aagcagtcaa 3590041 aacattcaga gaagagacag attataaaaa gaagctggct tcagccctga ttaccatgtc 3590101 aggcaatttt acagagatga gccagtttga agaagctgag gcttatttgg acgaagcaat 3590161 tcggatcacg agtgaattag aggatcattt ttttgaagcc cagcttttgc ataacttcgg 3590221 ccttctacat gcgcaaagcg gcaaatcaga agaagcggtt tcgaaattag aggaggctct 3590281 acagaacgat gagtatgccc gctccgccta ttattatcat tctgcctact tgctgatacg 3590341 agagctgttt aagatcaaaa agaaagaaca ggccttatct tattaccaag acgtgaagga 3590401 aaaattgact gctgagccga atagaatatg tgaggcaaaa atagacattt tatatgccat 3590461 ttatgcagaa gggggtcatg cggaaacgtt tcacttatgc aaacaacata tggatgactt 3590521 gttgtccgag aaagagtatg acagtgtaag agaactttcc attttggctg gcgaacggta 3590581 tagggaactt gagctttaca aagaagctgc ccactttttt tatgaagcat tacagattga 3590641 agaactgatt aaacgaacgg aggttatata aatgaaaaga tttctgattg gcgcaggcgt 3590701 cgcagcggtg attttatcag gttggtttat tgcggaccat caaacccact cacaggaaat 3590761 gaaagtcgct gagaaaatga ttggataaat gaaaaacccc cgcgggatgc gggggttcaa 3590821 tttaacgaaa gaatcctaaa acggtttgta gttttaggat tctttcatct tttcagcgtg 3590881 attgaaaacc cttgaagtct aggaagaacg agcattggag cgcagcgaat gtttggaatt 3590941 cgtgagcacc gaagcgcagg cctgacaacg aatgcgaggg tttgtcgaca cgctgaaacc 3591001 cccgcgggtg cgggggtttt cttattacag cagcttcttc cctaacaggg attctacgag 3591061 ctctactgct gttttgcccg ttttgttttt gtgatcaagg atcgggttaa cctcaacgaa 3591121 ttcggctgag gtaatgatgc ctgcgtcata cagcatttcc atagccaaat ggctctcccg 3591181 gtagctgatg ccgccgacga caggggttcc gacacccggt gcgtcgttcg gatcaagtcc 3591241 gtccagatca aggctcagat ggacgccatc acatgctgat aaataatcaa gggtttcttc 3591301 aatgaccttt gtcatgccaa gacgatcgat ttcgtgcatt gtgtacacct tcatgccgct 3591361 ttccttaatg tacttgcgct ccccttcatc aagtgaccgg gcgccaatga tgacgacgtt 3591421 ttccggtttg attttaggcg cgtagccttc aaggttaacc agtgactcgt ggccaatgcc 3591481 taggctgacc gcgagcggca tgccgtgaat attgcccgat ggtgaagttt caagtgtatt 3591541 caaatcgccg tgcgcgtcat accagatgac gccgagatta tcgtaatgct tcgctgtgcc 3591601 tgcaagcgtg ccgatcgcaa tactgtggtc accgcccagg acaagcggga attttttctc 3591661 ttcaatgact ttgttgacct tttgcgcgag tttttcattt cccgccaaaa cggaattcag 3591721 gtttttcagt tcctcgtcat ttttgatttt ttcgcgattg atcggaatgt caccgagatc 3591781 ttcaaccgta taccccatgt ctgacagcct ctcgatcaga tgagcgtacc ggatggcact 3591841 cgggcccata tccactccgc gtcgtgcttg tcctaaatcc attggcattc caataaccga 3591901 aatcgtttta tccatctgtg attccacctc aacatttaag ataatgtcct atgcgggtta 3591961 taacaaagat gacttgcgga caacgttttt aaagctctag ctgacgattt gcctgctggc 3592021 gttttttaat gacgacatga taaatgatgt agcaaatgat cataaacggt acgccgcaat 3592081 acagcgcgat acgctgctcc ggatcaaatg caagactgat gagcacgacc gtatttaacg 3592141 ttaggccgat cagcggaagc accgggtaca gcggtgtttt aaatttcaaa tcttctatct 3592201 tcccgccctc acggatatat ttgcgtctga acatgatttg ggaaagcgag atcgtaatcc 3592261 agccgacctg cgcgctcatg cccgccaaag ataacagtac catatatacg gtttcagcct 3592321 gcgcaaactt tgtcagaagt gataggcagg ccacagccat cgttacgatt aacgagtaca 3592381 tcggtacacc gcgctgattt gttttgccaa gcgctttgaa ggcttgtcct tcattcgcca 3592441 tcgcgtacag aatacgtgtt gatgcgtata aacctgagtt cgcaacagat aacagtgcga 3592501 ttaaaataac aaagttcatg atatcagctg catatgggat tccgatttgc tcaaatacgg 3592561 caacaaatgg actttccacg acacccgcct gtttccacgg aatcatgccg gcaatgacaa 3592621 tgattgaaag cacaaagaac acaagcgttc tccatactgt ctgtttgatg gaccgcggaa 3592681 tcgttttttc agggtcttca ctttctccgg ctgcaacccc gatcagctca gtcccctgaa 3592741 acgcaaagtt cacagtaatc atcgtaatca gcattgcctt tatgccgttc ggaaataacc 3592801 cgtcttcata aaaatgtgtc aaaaacggcg cctgctctcc gcccttcaga tcaatcaggc 3592861 caaacatggc agctccgccg agaataataa ataaaaggat aatcaaaatt ttaatgcctg 3592921 agaaccagaa ttcagattcc gcaaaggctt ttgtggtgat cgcatttaaa ataaacatca 3592981 gtgccgcaaa gaccagacac cagatccaca cgtctatatg cggaaaccag cgttgcatca 3593041 gctgccccgc tgataaaaat tcaatggcgc atgtaaccgc ccagccgagc cagtacagcc 3593101 agccgaacgc aaacccgaag gccgggctga taaatttcgt ggcataggtc tggaaggacc 3593161 ccgacacagg aaaggcgact gccagctctc ctaagcagag catggtcaaa aacatgataa 3593221 agccgcccac taaataggac agaaccgcgc cgagcggtcc cgcttggtta atggtaaacc 3593281 cggttccaag gaagaaaccg gttccgatca ctccgcccaa tgaaatcatg aacaaatggc 3593341 gtgatttcat tgtccgctgg agctgatttc cgttatcttg gtttgtattc acattctgca 3593401 ccccttcagc aacttgtatt ggatctaagc tggaacatct gcatggtgct atcccagttt 3593461 gctgtccaaa gagtctctat ctatttaata taaaattcac ttcttctcat aaagatacat 3593521 tatactaaaa tactgtagct gagcaaatag ggagtgctga tttttctgtt gtaaatttat 3593581 acaaacgaag tgaatatccc gccatggtgc ggatttatgc gtttcgcagc acgtgcttaa 3593641 ttttctctat cgcccaatcc aagtcctctt tggaaatgat taatggcggt gcaaaacgaa 3593701 tgactgtatc atgcgtttcc ttgcataaaa gtccctcttc cttcaaacgc tcacaatacg 3593761 gacgtgccgc ttcagtcaat tccacaccga taaacagccc tctgccgcgg acttctttaa 3593821 tgacagggct gtcaatactc tcaagctcgc ttttaaagta ttcaccaagt tcaagagaac 3593881 gatccgccag cttttcatcc tccagcactt ctaatgaagc gatagacact gcacatgcaa 3593941 gcgggtttcc accaaatgtt gagccgtgtg agccagggtt aaacacgcct aggatctcgc 3594001 ggtccgccgc aatgcaagag atcgggaaca caccgccgcc aagcgctttg cccaagatat 3594061 acatatccgg aacaatgccg tcccagtcac aggcaaacgt cttgcctgta cgtccgagac 3594121 ccgtctgaat ttcatccgca ataaacaaga cattctcttc cttacaaatc gccgccgctt 3594181 cctgtaaaaa tccttcaggc ggaatcacaa tgcccgcttc gccttgaatc ggttcaaaca 3594241 agaatgccgc tgtattcggc gtaatggcct gtcgaagcgc ttccacatcg ccgtaaggaa 3594301 tgagtttgat tcctggaagc atcgggccga atcctcgttt atattcctct tcagaagaaa 3594361 gagataccgc cagcatcgtg cggccgtgga agttcccgac acatgcgata atttccgctt 3594421 gattgtcagc tacgcccttc acttcatacg cccagcgtct cgccgctttc accgcggatt 3594481 caaccgcttc ggctcctgta ttcatcggca gaatcatctc tttgcctgtc agtttagctg 3594541 ttttttcgta aaacggccca agctgatcgt tatgaaacgc gcgtgacgtg agggtgattt 3594601 tatcagcctg atcctttaat gcctgaatga ttttcgggtg tctgtgcccc tggtttaccg 3594661 cagagtaagc actcagcata tccatatatt cattgccttc cgggtccttt acccaagcac 3594721 ccagcgcttc agaaataaca atcgggagcg ggtgataatt gttggctccg taatgagacg 3594781 tctgatcaat aatttctttg gatttagata aagctgtcat atttgaattc ccccttgttt 3594841 tctgtttcaa catgttatcc tgctttccct ttatataaat gcaagttctg tgccaaatca 3594901 agaattcgtg tgttttctac aattttcgag gacaaggtgc aaaaacattc tgatatttcg 3594961 agcgaaaatt tcagcaagtg caaaattctt ttgcatatcc tctccgtttt tttataaaat 3595021 agaagcaata ttaagaaaat aattgaggga ggttcataca gtggtcaaag acagcgaatt 3595081 cctcacattg gtttttcaga gtattttaga tgaaatcgat gttggcctgc acgtggtaga 3595141 cgagcatgga aacacaatcg tttataacaa taaaatgatg cagattgaag atatggagaa 3595201 gcatgacgtc ttgaataaaa acctgatgga tgtgtttatg ttttcaaagc agcaggacag 3595261 cacactggta caggctcttc aggaaggcaa gacgattaaa aacgtcaaac agagctattt 3595321 caataataaa ggccaggaaa ttacgacgat caatcataca tatcccatcg tccaagacgg 3595381 caaaatcagg ggcgccgttg aaattgccaa ggatgtgaca aagctggaac ggctgatcag 3595441 ggagaatatg aacaaaaaag gcagcacaac ctatacgttt gacagtattc tcggcaccag 3595501 tccggccatt caagacgtca tcgaaaacgc caagcgggca acccgtacgt catcatctgt 3595561 ccttctagca ggcgaaaccg gcacgggaaa agaactgttc gcgcaaagta tccataatgg 3595621 aagcgatcgt tctggcggcc cgtttatttc gcaaaactgc gcggcactgc cagacagcct 3595681 tgtggaaagc attttgtttg ggacgaaaaa aggcgcgttt accggcgctg tcgaccagcc 3595741 cggcctgttt gaacaagccc acggcggcac actgctgtta gatgaaatca actcgctgaa 3595801 tctcagcctt caggcgaagc tgctgcgcgc ccttcaagaa cggaaaatca ggcgcatcgg 3595861 ttcaacaaag gatacaccga ttgacgtacg tattattgcc acgatgaatg aagacccaat 3595921 tgatgcaatt gcaggcgaac gaatgcggaa ggacttgtat tacaggctga gtgtcgtcac 3595981 actgatcatc ccgccgcttc gggaacgaaa agaagacatt ttgcttctcg cgtcggagtt 3596041 catccagaaa aacaaccatc tgttccaaat gaatgttgaa cacatcagcg atgacgtgaa 3596101 gcaatttttc ctttcttatg actggccggg aaatattcgc gagcttgagc atatgatcga 3596161 aggcgcaatg aatttcatga cggacgagca aacgattacg gcttcccatc tgccctatca 3596221 ataccgcatg aaaatcaagc cggctgacat cccagagccg gaaacaccaa gacaccagcc 3596281 agccgcggac ttaaaagaaa aaatggaaag cttcgaaaaa tatgtgatag agaacgtgtt 3596341 aagaaaacac ggccataaca tctcgaaagc tgctcaggag cttggcatca gcagacaaag 3596401 cctccaatat cggctgaaga aattttctca ctcgtctaac gaataatccg gagcaggaag 3596461 cctgatcaga aaaacagtgc ctctgccgat ttcacttttc acttcaatcg tcccattgtg 3596521 attgtcgata atcgatttcg ttatggcaag gcctaatccc gaacctccat atttccggga 3596581 gcgggatggg tctgccttgt aaaaccggtc aaacactaaa aaacgtcact tcttatgcat 3596641 tgaagaaaga aaatggcacc tatgtgtatc acagccagca accacacggt acaaaccatt 3596701 aaagtccatg caaataacgg aagtatttgc agctaactgc catttgctgt ttcacgtgta 3596761 acatccatct tgtatttttc ttcatattcg atatatcctt tttcaactga acgggcgtga 3596821 cccctgttca gttttttttg catatcaaaa cagcctggca acgatgccag actgctttta 3596881 ttaactgcct aattggtctg cggaggacag cttgatatca acagattttt cttttccgcc 3596941 gcgataaaac ttcaccttca cccggtcacc gacttttttc tgataaagcc gttttcgcag 3597001 gtcaacaata tcatttactt tgtatccgtc aaattccgtg atgacatcca gttccttcag 3597061 ccccgctttt ccggcaggtg aaaaggcgtc tacacccatc acaaccgctc cattggtgac 3597121 gttcttagga agctttaatg tttcatccca atgatagctt gcgatgtcac ttagcgattt 3597181 catctcaatg ccaaggaacg ggcgtttgac ctttccgtat ctctctaaat cctctatcac 3597241 agggatcacg agcttagacg gaatggacag gccaatccct tcaaccgctg actcggcaat 3597301 tttcattgaa ttgatgccaa tgaccttccc atccatattt aacaaagcgc cgccgctgtt 3597361 cccagggtta atggccgcat ctgtttgcag gacttcagcg ttccagtcag gctgtccatc 3597421 accgtttgaa tctactggga tcgccctctc cgtacccgag atgacgcctt gtgtgacaga 3597481 gcctgcaaac tcaaggccta acgggttccc gatcgcaata accggctccc cagacttcac 3597541 tttatctgaa tttccgaaat cagcgactgc tttaatctta tcgcttttca cccgtaaaac 3597601 ggcaaggtcc atcagctggt cgctgccgac aagatcagct gatacacgtg agccgtcttt 3597661 caagctgatt tcaatttggg aagcgccttc gatgacatga tggttggtca cgacataagc 3597721 ggaatggtca tttttcttat agatgacgcc agagccgctc ccagcctcgc cgctctctcc 3597781 ccaaatatct gatttttgga tgttcacaac accgacaacg gcgggcgaca tattgctgac 3597841 aatcttggtg acggcattgt tgacactgac attcaccgtc ctgattgatt cccggccatt 3597901 gttgttttgc tgctgatcta aggcgcctgt atccagccct tcatttgaaa ggtacggcat 3597961 gataaacgcc attaatacgg caccgacaat cacgccaatc agactcgaaa gaaaatatcc 3598021 ttttttgctt ctctttggct gttcaggagt agtatgttct tcctcacgtt cgtaatccac 3598081 catattccat cctttccaag aacgttaata tggttatatt gtgggttaga aactcctaga 3598141 atagtcatga tttacataga aaaattatac agcgcaaagc ggagtggcct tcttcggatc 3598201 ggtgtcgtat aagtcaaatg tctcacccgt cacaaatcct ttagaagcca atgtctgctg 3598261 cacagacatt cttgccagct ccttcatgtt gttgtcctgg ctcaaatgcg ccaggtaaat 3598321 acgagacgtc tcatcgccaa tgacatccgt catcgccaag gcagcatctt catttgacac 3598381 gtgcccgacg tcacttaaaa tccgccgctt aatgctccat gggtatcttc ccatttgcag 3598441 cataccgaca tcgtgattgc tttcaaacac aaatacattc gctgaacgga taatgccttt 3598501 catccggtcg ctgacatatc ccgtatctgt cattaacgcg agctttcggc cgctataatg 3598561 gaatacataa aacatcggtt ccgccgcatc gtgggaaacg ccaaacgatt caacatcaag 3598621 tccgccgaac gacttcaccg tctccattgg aaatacaaac ttttgatcgg tgtcaatttt 3598681 gccgatttga ttctccatcg ctttccaagt cttctcattc gcatagatcg gaagcttgta 3598741 ctttctggcg acgacaccaa ggcccttaat atggtcacta tgctcatgcg tcacaaaaat 3598801 gccgtctaca tcatccagct tacgcccgat ctgcgccatc agcccatcca tggcttttcc 3598861 gctcaaaccg gcgtccacta aaaatgcgtg atcctctgtt tcgaggtaaa acgcatttcc 3598921 cgtactcccg ctcgcaagta cgctaaattg caagctcatg tttgtctcac tccattattt 3598981 tcattgatct gtatctaaaa tcgtactctc caaagcattc acagtaaaat actcttgtac 3599041 tgtctttttc tcaccgttca cttttttctc gtactcgacc gtaattctcc ataccggcgc 3599101 cagcacctgc gtacttgtca gcggatattg tgctacatag ccgaatttac agctcttcac 3599161 agtgctgtat tcttttaatt gattttgata gtacaatagc tcaaccgcat ccatttcagt 3599221 aattaagctt tctttctgga tttgcttgaa ggtctcaagc gtagtctggt cgtatgacac 3599281 aacctcgttt ttaccgttta agtgcagcac cacttgcccg atcatattag agggattgtc 3599341 ggtcttttgg taaatataat gaccttcgta cgtttggaag aaaataattt ctttcttcga 3599401 tttatcaacc ttccaaagct tatatttttc gccatcttga attttcgaag aaacaagtgc 3599461 ctgagcatcg tcctcgatat ccttctttga tagtgcgatt ggatttgcaa acttcatttt 3599521 caggctcgtt actttatgat catcactagg catgtccatc aaaggctttt gatccttcag 3599581 cgcctcaatt tcctccttgg agaaagactt ttgatttgcc gtgatccgat agccttctgt 3599641 tgcttcctta ttcaagcctt catacgtgat atgatcggcc ttcatgtcat gctcgacatc 3599701 atttttaatg acttcatatt ctttgccggt agcctgccat ttttgaaaaa actgatagcc 3599761 taagaaaata tctaaaatga ggaaggcaac gatgaagatt gattttgtct tattccactc 3599821 cactgttagc cccctccttc ctcaataaat cctttgtaat cggcacaatt tttccattta 3599881 ctttcatcgc ccaaaccggt tccagttcaa cgagaggatc atcgttggtt gatgttgata 3599941 ccaattgata agcaaggaag atctgatcaa ttttgtccgt atcataagcg gtttgtttcg 3600001 aaagcagcat cttcacttcg ctgccgccca tgagctctgt ttcacttgtt ttaatcggat 3600061 tcgttccgag actgtaattc ggccgcttat agctgagaat atcatcattc gcccattgca 3600121 ccgtaatcgc cgatgtcgcc ccgaaaggtt tggcggtgct gttaatgacc gggatctgat 3600181 ccataaaaat atagaagctc aactgctggc tgtcattgat attgaaaaat tgatagtgat 3600241 ccgtccagct tccggtatcc tcaaggtatt tttggctctt tttgattaat tcacctgttt 3600301 gataggatgt gctctgcacc aaattgcgct gctgaaattg cacctgtctc tggcttagat 3600361 tcacatctaa ccggctgatc ccatctgtca gcacatttct gttggtgtaa ttcgaatctt 3600421 ctcttacaat gctcggatca ctaaacaaag cctgcttaaa ggtatttgtt ttaatcgatt 3600481 ctgtgacaaa ttcttttttg tccatcgtaa gcggtttgtt cggcagcaag aactctttct 3600541 ttgagccaat ggagaacaaa ctgaacgccg gcatatttga ttgcctgttt ttcaagtcgt 3600601 tcataatgtt ccggtagttt gctgattcaa ccgtcacttc aagaatgagc tgcttgctgt 3600661 atgacaccaa atagattttc ttgttcgctt ttgtttcatt gaacgggatc agaatatggt 3600721 caaacgaact gtattcaaac gactgattag accatttaaa cagcgtttgg aaaatatcaa 3600781 tcgggatcgt atcgctgaat tgcaagtcaa gcttggcttc agaaccgcct attccataaa 3600841 accagctttt gaatccagcc ttgtcatact gatccgaaat atctttaatt cctttcacat 3600901 cccaatgcgg caagtcagac caaatttctt catagagggc attgtcatcc actttgtaat 3600961 gagcgccgtc atcatggata aacatgtccc ttggccttac cgtttcagac agcttttggg 3601021 tggttttttc gattttatgt ttcacacgaa cagtagactc tgttgaggat gagccttcag 3601081 aaaagtttgg ctggaacgtc catatccccc atgtaaaaac aagactgatg acgacgagta 3601141 ccgtaagtaa tatcgttttt atattttcac gcttcatccc aatcatcctc ttgttcctct 3601201 ttatatggaa gagtaaatgt aatcgtcgtg ccttttcctt ctatgctgtc cgcccaaata 3601261 tctccaccgt gcgcctgtac catttccttg gcaatcgcca atcccagacc ggtgccgcca 3601321 agctttctcg ttctcgcttt atccaccctg tagaagcggt caaagacttt ttcgacatct 3601381 tttttcggaa tgccgatccc ttcatccttc acgctgatat agagaagttc ttcctcttca 3601441 ttgacatcaa tcgagaacgt gacatgtccg ccttccggtg aatattttaa agcgttagaa 3601501 ataatattat cgagcacctg cgttatttta tcctggtcaa tctcgacata cagatctctg 3601561 tccggcagat tgcggataaa ctccacatgc tgctcttttg tcatttcaaa acggtcaata 3601621 ataagtgaca taaaccggac aatctgaatc cattcccggt taaattgata atctttactg 3601681 tcaaatttcg acagctgaag cagatcattg acaagccgga tcatacgctc tgtttcattt 3601741 tgcgtcacca ttaagaagcg cggagcaatg tctttatttt cccacgcgcc ttcagctaac 3601801 gcttctaaat agctgcgcat tgtcgtaagc ggcgtccgca gctcatgtga tacattcgca 3601861 acgaattctc tgcgttcctg atccattttc tcttgttcgg ttacatcgta aatgacagcg 3601921 attaaaccat caattttgcc gtgttccctt tgaatcacag agaaattcac gcgaagcacc 3601981 gttaattcat catcgcgctc aatttcaagc agcatagaat cctgctgttc cactaaatct 3602041 tcaaaagtat aattctcttg aagccccagc aaactcgtaa tcggcatttc taaggctgtt 3602101 tcacgtgaaa cgttcaacag ttccagcgcc gggctgttta agagaataat cgctccgttt 3602161 cggtttgtgg cgataacgcc gtctgtcata taagcaatga cagaggctag ctttctgcgt 3602221 tctccttcag tcatcgcctg ggcatcttca agctctctcg ttaagtggtt aaacgttgtg 3602281 gccagctgcc caatttcatc atgtccatac tttttaacct tcctcgagaa attccctttc 3602341 gcaagctcca tcgcctgctt tcgcatatct gaaagcgggt gggtaatggt tcttgccaga 3602401 aaaataccga gaagagccgt caaaacaagt gccaaacctg tgccggacgc cagtatcgtg 3602461 ttgatcgtct tcatttgatt aaagacatct tccatactcg cgacaacgta gatcgcgccc 3602521 acaacctctt ggttttcagt catgacgggc ttcgcggaaa taagaactct gattttgctt 3602581 ttcgggtcat aatattttct taaatacgac tgtttggtag aaaagattct tttgaaaatc 3602641 agatcggtcg tttgtttccc agccacttcc tcaccgtacg gctttgaaga accgaccact 3602701 tcatagcttt tatctacaaa gctaatttcc cgaacctcat cacttttcgt gaagtcattc 3602761 aaaatacggc tgacgtcatc ctttatgacg gtactgtcgt tatcgctctt atattcttgt 3602821 tcgatataat aagaaaggtt gtcgattcgc tgattcagcg attgttcata agagctgatc 3602881 agcgacttct ctacctgatt gacaaaatac acaccaatga tttgcatggc aatgataatc 3602941 aaaagcacat aaatcaaggt aatcttaaat tggatcgacc gaaaaaaacc aaccttattc 3603001 atatgggcat tagtcctgtt ctgggtttct caagtaataa cctacaccac ggcgtgtgac 3603061 gatccaattt ggatggctcg ggttgtcctc gattttttca cgaagccggc ggactgttac 3603121 gtcaaccgtt ctgacatcgc cgaagtaatc atagccccaa acggtttgaa gcaaatgttc 3603181 acgggtcatc acttgtccga tatgttttgc taaataatga agcaattcga actcacgatg 3603241 agtcaattcg attgtttcgt ctcgttttga tacaacgtac gcgtcaggga agatgacgag 3603301 agagccgata tgaatctcgt tagaggaagg ctcttcctcc gcaggcgctg ttgtcagctg 3603361 gcggcgcagg ttcgctttta cacgcgccaa gagctcgcgt gtgctgaatg gttttgtgac 3603421 atagtcatca gcaccgattt caagcccgat aaccttgtca atttctgaat ccttagccgt 3603481 cagcataatg attggcatat cgtatttctt tctgacttcg cggcatactt caacgccgtc 3603541 tttatttggg agcataatat ctaaaagaat taaatcaggc tgaagctctt ctaccatttc 3603601 aacggcttcg tttccgtcgt gggcacagtg cacttcatag ccttcttttc ttaagttaaa 3603661 ttccaatata tctgcaatcg gtttttcatc atctactaca aggatctttt tatccatcat 3603721 tttgattttc ctcctgccga atgacttcat ttcatctata taacattcgt ttcatcactt 3603781 atggcccatg taaagaatgg gtccttgtct attataacgg tttaaggtca aaagataaaa 3603841 aaaataaagg tttagaaaaa aaacacatgt ttcaccttta tcgccagttg tttatctatt 3603901 gtcatgctgg tcaacttttt ttaaaaaaga taactttatt gaaacctccc ctcaccggag 3603961 tgcgtcttta tcaatgacgt cttcttcttt gaaccggccg cagggccggt tctccctttt 3604021 tcttctatta taacactcct catgtttgcc tttttcctaa aagaaaaaac gcacctacga 3604081 ttgcagatgc gtttggtaag tggctcggga cggaatcgaa ccgccgacac acggattttc 3604141 agtccgttgc tctaccaact gagctaccga gccaaatgtt ttatttttct ctactaagta 3604201 aagtaaaatg gcggtccgga cgggactcga acccgcgacc tcctgcgtga caggcaggca 3604261 ttctaaccaa ctgaactacc ggaccttaca gtaattgccc ggagagctgt cgtgtcagct 3604321 ctcacagaca aataaggaat ttagcaataa cgctaaagta aatcaatgac ccgtacggga 3604381 ttcgaacccg tgttaccgcc gtgaaagggc ggtgtcttaa ccgcttgacc aacgggcctt 3604441 cacgaaatgg tgagccatga aggactcgaa ccttcgaccc tctgattaaa agtcagatgc 3604501 tctaccaact gagctaatgg ctcttaaaga tgtcggaatt tctatagagc aaacgactta 3604561 aatctagttc tcatcttgta ctctattgaa gcagtttccg taacaacgag atttataata 3604621 tcacgaacaa atagaagtgg caataacttt tttggttttt tttcatattt ttttctcaga 3604681 ccaacttata tgcggctttc aaacaaaaaa caagcccctt aaataggggc ttgcagacat 3604741 attctattta gttcgcacgg tacacactgc gaaggacatt tgtttgtgag cggtctggac 3604801 cgacagagaa aatagaaagc ggaatgcctg tcagctgaga cacacgctca agataatggc 3604861 gcgcattttc cggaagctcg ctcaagctct tcgcacctgt aatatcctca gtccagcccg 3604921 gcatttcttc atataccggc tcacattcag caagtgcctt aagacttgct gggaattctt 3604981 caatgatttc gcctttgtag cggtacgcca cacagatttt caacgtttca attcctgcta 3605041 ggacgtcaat tgagttcaga gaaagatctg taattccgct cacacggcgg gcgtggcgga 3605101 caacaacgct gtcaaaccag ccgacacggc gcgggcggcc tgttgttgtt ccatattcgc 3605161 gtccgacttc acggatttga tcgccgattt catctttcag ctcagtcgga aaaggaccgt 3605221 cgccgacacg agtcgtatat gcttttgata caccgacaac gtgcttgatt ttggtcgggc 3605281 cgacaccaga accgatcgtg acaccgccgg caaccgggtt agatgacgta acaaacgggt 3605341 atgttccttg gtcgatatcg agcataaccc cttgtgcgcc ttcaaataat acacggcgcc 3605401 cttcatcaag agcatcgttt aagacaacag atgtatcgca aacatacttt ttaatctgct 3605461 gtccgtactc ataatattcg tctaagatat cctcaagttt aaacccttct gtctcgtaca 3605521 ttttctcgag aagacggttt ttttcttcaa gattgcgctc aagcttttcc gcaaacgcgt 3605581 cacggtctaa cagatccgcg atgcgaattc cgatgcgggc tgctttatcc atgtaagcag 3605641 ggccgattcc ttttttcgtt gtgccgatct tgttagcccc tttacgctct tcttccactt 3605701 catccaattt caaatgatac ggcagaatga cgtgagctct gttgctgatt ctcaggttat 3605761 ctgtactcac gttgcgctca tgaagatacg caagctctgt gactaatgct ttcggatcta 3605821 caaccattcc gtttccgatt acacacgttt tatccttata gaaaattcca gacgggatta 3605881 agtgaagctt atatgtgatt ccgtcaaact tgattgtatg ccctgcgtta tttccgcctt 3605941 gataacgggc gatcacttct gcattttctg ataggaaatc tgtaatttta ccttttcctt 3606001 catcgcccca ttgcgtacct actacaacta ctgaagacat gtccgtgcac ctccgttaac 3606061 ctttcaaaac gattctattc aaacaaatca agtttatcag tgaagaaaca gaaagtcaat 3606121 tgtaaatccg aacattaatt tattgtaaat ctatattcgt tcgcttccat tcgttttata 3606181 agcgttttct cactgctttg tcataaaaag cttgcgaaac tttcatcctt tagcataaga 3606241 aagaatcact tgcctgatat cccttttgaa ttcataaaaa cgatccgcca gccgtccggg 3606301 tcctctatcg tcacgccccc attgctccag tacgggttct ctgattcgac ctcttgatag 3606361 cccatgtgct ttagctttga agtgatcgct gccagttcaa ctgcattcgg cacataaaaa 3606421 acaagaaggc tgtcgggatg gggaacgggg gcagtgcttc ccccttcata ctgggtgaat 3606481 tccaaatgat aatcggcatg aggaaggccg aacatgacac cgtcataccc gttatgctgt 3606541 gaaaattctc ctattcgttt caaacacagt ccctcttcgt aaaaacgaat aatctcatca 3606601 agctggcccg taggacgcgc aattcggatt tgtgctgctt gaaaagacga aaaacgtttt 3606661 cccatattgt taccatctcc tttttgcacc attttattaa aacgctttca atttttcatc 3606721 cgctgagcga acgtcatttc ttccatcttt cgaatgaaaa aaaccccaag agcagctctt 3606781 ggggcttatg cgccgggcgg aacgcctgcg tcatcaaaac gccgttccag gttgacgaat 3606841 ttgttgtatt cttttacgaa cgcaagagac acggttccta ccgggccgtt acgctgtttg 3606901 gcgataataa tttcgataat atttttattc tcggtttctt tgtcatagta gtcatcacga 3606961 taaaggaacg cgacaatatc cgcgtcctgc tcgatacttc ctgattcccg gatatcagac 3607021 atcatcggac gtttatcctg acgctgctca acacccctgg aaagctgaga aagcgcgata 3607081 acagggactt gcagctccct cgcaatcgac ttcagttcac gggaaatttc agatacttcc 3607141 tgctgacggt tgtcctttga acgaccgctt ccctgaatca attgcaggta atcgatcaaa 3607201 atcatgccca gcccgctttc ctgcttcaag cggcggcact tggcacggat ttcactcact 3607261 cgaatacccg gtgtatcatc gatgtaaatc ccgctgttcg ataggcttcc cattgccatc 3607321 gtcagcttgc cccaatcctc ttcggtcagg ttacctgtac ggagattctg ggcattgata 3607381 tttccctcgg cacagagcat acgcataacg agctgctcgg cacccatctc aagactgaaa 3607441 atcgctacgc tctcatcggt cttcgtcgcc acgttttgtg cgatgttcag ggcaaaggct 3607501 gttttcccta ctgaaggacg ggcagccaca atgatcaagt cgttgcgctg gaaacccgca 3607561 gtcatccggt caagctccgt aaaccctgtt ggaattcccg tgatatcacc ttttcgattg 3607621 tgaagctgtt cgatattatc ataggtctgg acaaggacgt ccttaatatt ttggaaggca 3607681 ctcgtgtttt tgcgctgtgc cacttccata atcgtttttt ccgcttcact gagtaaatcc 3607741 tcgacctcat cctcacgggt atacccgtct tgagcaatcg ttgtcgcagt tctgattaat 3607801 cggcgaagaa tcgatttttc ctcaacgatt ttcgcgtaat attctatgtt agccgctgtc 3607861 ggcaccgagt ttgcgatatc tgtcaaatat gaaataccgc ctacttcttc cagcaggtct 3607921 gtgttcgcaa gctctgatgt aactgtcacc agatcaaccg gttcacctcg gtcaccgagc 3607981 accagcatcg cattatagat tttttggtgg gacattctat agaaatcatc tggaatcaat 3608041 acttctgaag ccagtgttaa agcagacggc tgtaaaaaaa tagcgcctaa cacggcttgt 3608101 tcggcttcta tattttgcgg aggaagccgg tcattcagaa ggtctgtcat gctaagcacc 3608161 gtcctctcat taaaaaatct ccaacctcca ttctaccatt tctacagaaa aaaaatagaa 3608221 aaattgtctg tttcctgttt ttttcagtta gcagattgga tcgtttcgga cagtaacaag 3608281 gcgggaaaaa tgcaataaaa cataagggag gaatgaaaga tgataaagaa atatgcgatt 3608341 acacctaatg ttgatgcgga cggctggttt attgaggtgg agaatgtagc gccgacagct 3608401 ttgtatacgt ctaaagacgc cgctattgaa aaggccaaac aggtggctaa ggaaaacagt 3608461 ccgtctaagc ttgtaattta tgaccagttt aaaaatgtgg aagaagaaca ctcattttaa 3608521 tgaatgaaag ccttcgctgc agcgagggtt ttttagcggt tatcggttta tttcatccat 3608581 tggatgccta tgtgcatcat caaatctgcc gctttttgat acagatccca ctccccgatc 3608641 gaagcaaatt tccccatcag ctcctgaagc tttaacctca ttgctatata ttcttcgaaa 3608701 gtgacagctt tttcagtgtc tatttggtgt tccttcagca tttgttttaa taaggataac 3608761 ggtgcgtgca taagaaccct ccttacctct tttataacgg tcattttccg attgctctat 3608821 tcctttgtga catcttctta catttcacat ctgattcttg tacaatggac agaagagagg 3608881 agggatcttt tgtgagacct ttgcaaattt ctgccgaaac tgcacaaaag cttgcagagt 3608941 ccttgaatct gccgcttgaa cagatcatgc atatgcctca gcatattctg cttgccaaaa 3609001 tggctgaact gcaaaaagag gacaaatcat agccttcatt cacatacttg cttacctgtt 3609061 tcgggataat atcatgtata tgttagaaaa gaggagtaac tgctttgcca catccacata 3609121 ataaaaaaat ccaatcattt tggctgatca ccggcattat ctttatcgcc tttaacttac 3609181 ggcccgcgat cacttcagtc ggtccggtca tcagctctat ccgggcagag ctgcacatgt 3609241 ccaatggggc agccggtttt ttgaccgcac tgccgctgct ttcgtttgca gttctttctc 3609301 cgcttgcacc taagcttgga cagcgcctcg gtaatgagcg aactttatgg ctaggtctcg 3609361 tgatactgct gatcggtgtt ctgactcgtt ctaccggcta tactgccgct ttgtttttcg 3609421 gaacagcact tatcggcgtc gggattgcga ttggtaacgt acttttgcca agcttaatca 3609481 aacataaata ccctgaaaag ccagggatca tgatcagcct gtatacgaca tcaatgaata 3609541 tattcgcagc tttagcatcg ggtgtcagcg ttcctttagc gacccagatg aatggcggat 3609601 ggaaacaagc ctttctctta tggggcgggc tggctttact tgcattgcta atctggatac 3609661 ctcagctgcg ccatcgagat acggcaaacc agacaatgaa gctgcaatcc agttccattt 3609721 gggcttccaa aatggcatgg tatgtcacca tctttatggg cctgcaatcg tttttatttt 3609781 acagcagcat cgcttggttt cctgaaattc tccgttcaca cgggattgat acggcaacag 3609841 ccggatggat ggtatcactc atgcaatttg cgagtctgcc ttccactttt ctgacgccag 3609901 ttttagctga ccgtgtgaaa cagcagcgcg gtatcgttgc ggcgctggcc tcagtttatc 3609961 tgatcggcct ttgcggatta ttagcgggcg gaagccatac attgcttgcc atctggatga 3610021 tcattatcgg tatcggacaa ggctccagca ttagtctggc ccttactttg attggtctcc 3610081 gcagtgaaaa tgcccaacag gccgctgcgc tgtcaggcat gtctcagtca ttcggctacc 3610141 tgctggcagc agtcgggcca atctttgtcg gctatctctt tgaccagacg cattcttgga 3610201 cgatgccgat tgtgcttctc attgctgccc tgatcgtaat gggagcagcc ggacagggag 3610261 ccggacgaga tcgatacatt ttccagtcag aaaaacaaag aaattcagca taaagcgggg 3610321 aagatatctc cgcttttttc tttgaatatt tatggtttat tcataagttt ttcatatttg 3610381 ttttttacaa tgagacacca taaagaggtg aaaaacgatg aaaaccaaac gattcgacgc 3610441 agcccttatt cttattttgc tagcagcagc ttttttgaat acgtatcaca tttggcagga 3610501 tgatacagca aaccagtact atttggcggc tgtaaaaagc atgacgcaaa gcttccataa 3610561 ctttttttat gcgtcatttg acccttctgg atttgtgaca gtagataagc ctcctgtcgt 3610621 gttatggatt caaacgattt tcgcactgat tttcggtgtt cacacgtgga gtgtcatcat 3610681 tccccaggct cttgccggag ttggatctgt cttccttctc tacagaatgg ttaagccgac 3610741 ttttggagtt ggagcggccc gcattgccgc acttgtcatg gcactgaccc ctatcgcagt 3610801 agctgtcagc cggacaaaca atatcgacag catgcttgtt tttaccttat tgctcggttc 3610861 aacttgtctg cttagggcag taaaacaagg caagctggtt tggctgctga cggcatttgc 3610921 cctgattggg ctcgccttta atatgaagat gatgcaagcg tttatggtat tgcctgcatt 3610981 tgtgttattc tacctgattg catctcgggt ttctctgaag aaaaaaatcg ggtccctgct 3611041 tctgtctctt gtccttctga caggcctttc actctcatgg gcgattgcag tggattcagc 3611101 ctcttcctca agccggcctt atgtaggaag cagccagact aactcagtgc tagaactggc 3611161 ctttggctac aacggcacag agcgtctgtt tgggcaaact acgggccttg caaagggtga 3611221 tatgaatgct gctggcggag ggaacatgca gaatcaagac aacatgcaag cgccaaatgg 3611281 caacggttca tctttttctc agaacggtaa tcaatcattc ggaaaccatt cacaggcgcc 3611341 tcagccgcct aacggacaaa ccggcgctct caatggaggc ggaggcacac ctcccacagg 3611401 tggcaacgga cctggaaatg gagggcctgg cggcggaggc ggaaaaagcg tgaatatgtt 3611461 cggcaccggt gatcctggac cgcttcgtct cttccaatca gcactttccg gccaaatcag 3611521 ctggatgctt ccattctcat tgatcggatt actgggcgca atcatcagct ggtaccgtga 3611581 tcgccgcgga catgctgcta aaatgaaaga aacgctattc tgggcggctt ggcttgttcc 3611641 cgtggctggt ttcttcagca tcgcaggatt cttccaccag tattatttga ttatgctggc 3611701 accgccgatt gccgcccttt ctggtatcgg atggtatacg atgcaccgct tatacaaaaa 3611761 taataaagac tggtccagct atcttctgcc ggcagccgtc ttgatcacag ccgtgtttca 3611821 ggtgtatatt ctgagcgctt atacaagcca aatcggcagt gtatggatgt atgtcctggg 3611881 gctcttagga ctgggcatca cccttgcact tctgatgctt aaacgcagcc atccgttcag 3611941 taagctgctg accatcatca gcttgtgcgt tctgcttctc acaccagttt actggtcagc 3612001 aacgccgctt ctatacggtg gcaacagcgt ccttcctgaa tccggcccgc agctcaaagg 3612061 ctcagcaaac ggcgggaaca tgttctcttc agaggtcgac agcgggctcc tgtcctatct 3612121 gagaaaacac aataccggcg aagagtattt atttgctact ttgacaaccg taacagctgc 3612181 gccatacatc atttacgaaa atgaatctgt tatggcaatg ggcgggttta acggcacgga 3612241 tcccattctg actgtgtcgg aactgaaaaa actgatcaaa gaaggcaaag tgaaatactt 3612301 ccttctgtca gaaaacaact caggcaacag cgaacttgtt tcctggatta agaaaaacgg 3612361 aaaagaaata acatctgacg agtacagcgg ttcctccagc agcacaaaca gcgtgcaggg 3612421 aatgcgaaga ggacctggcg gagaaagcca gcaaactctt tatctcgtgg aataaaaaaa 3612481 gaggcttgga tgaatccaag cctcttttct attaagcttc ttcttttaca tgtaccttta 3612541 acacagcctg cacttcagga tgcagcttca caggcacgtt tgtatatcct aatgcacgaa 3612601 tgccgtccgg cagttcaagc ttccgcttat ctactttaat gttatggtct ttttggagct 3612661 gttcagtgat ttgcttgctt gtcactgaac caaataaacg gccgccctca cctgattttg 3612721 cgctaagctc aacagtcagt ttttctaatg tctctttcaa gctcttagcc tgctcaagct 3612781 cagcaatggc ttcttttttc tctttctgct tttgtccgtt taacgcgctg atgtttgacg 3612841 cgttcgcttc aaccgcgagg ccttttttaa ttagaaagtt atgcgcataa ccgtctgcta 3612901 cgtttttgac ttcgcctttt tttccttttc cttttacatc ttgtaagaaa ataaccttca 3612961 tctctgtacg cctccctcaa aatactcatc tatggcgtgc ttcagccgtt ccagcgcttc 3613021 agaaactgaa atgccggaca actgagtcgc cgcatttgtt aaatgccctc cgccttccag 3613081 ggcctccatg atgatctgaa catttacctc gccaagcgac cgagcactga tacaaaccgt 3613141 ttgttcatcc cgtctcgcca ccgcaaatga agcctcaacc tcactcatcg atagcagcga 3613201 atcggcagcc tgcgcaatca gcacttgatc gaagtattcc tcttcatttt caggaagaga 3613261 agcaatcgca atgttatctt tatagaggac cgtatgctgg atcagcttcg cccgtttaat 3613321 ataggaatca acggtttctt tcagaaactt ctgcaccagc accgtgtcgg cgccttttgc 3613381 ccttaaataa gaagccgcat cgaaagtccg cgagcccgtg cggagagaaa agctctttgt 3613441 atccactatt ataccagcta atagggctgt tgcttcaatc atattgattt ttaagcgctt 3613501 cggctgatat tcaagcagct ctgtcaccaa ttccgctgtg gaagaagcgt atggttccat 3613561 ataaacgagc agcggatctc tgataaactc ctcacctctt cggtgatggt cgatgaccac 3613621 gatatgttca attttattga ccagccgttc ctccatgacg agtgacggct tatgtgtatc 3613681 aacgatcaca agcagtgtgt catcattgga aatctccatt gcttcttcag gcgtaataaa 3613741 tcttgaccac agttcttcat attttttgat ttccccaatc aaacgctgca cacttgatcc 3613801 gatttggttt gggtcaatca cgataaaacc atctttgtta tttgcctgag ccacctttaa 3613861 aatcccgatc gctgcgccga tagaatccat gtcggggaat ttatgcccca tgataatcac 3613921 attgctgctt tcggtgacga tttcctttaa ggcgtgagaa atcacgcggg cccgcaccct 3613981 tgttcgtttc tccattgggt ttgttttacc gccgtaaaac ttcaccttgc cgtttggcag 3614041 cttaatggct acctggtctc cgccgcgtcc cagtgctaag tccaagctgg attgcgccaa 3614101 atcgccaagt tctttcaggg aagagactga agccccgaca ccgacgctta acgtcagcgc 3614161 tacaccgtca aacgaggttt tttcccgcac ttcatcaaga atcgaaaact tcgaattttc 3614221 gagttcagtt aagatatgtt cattaagtac agcaataaag cgttctgaag acgtcctttt 3614281 caagaagatc ccgtactcct gcgcccaagc gttcagcaaa gatgtcacct ggctgttcat 3614341 cgtgcttctc gtctggtcat ccaatccttg tgtcacatca tcatagttat caaggaaaat 3614401 atatgccagg acggttcttt cgttttcata tagcttttca atctggattt gttctgttac 3614461 atcaaagaaa tataagagac gctcatcccg tttgatgaca accctaaact tgcggtcatt 3614521 caatgtaacc gtttccgatt ccacctcttg tttgataagc ggcactaccg attcacaagt 3614581 atcgtaaagt gatctcccca ctaaagtgct ttcattaaaa caagaggaaa gaaacggatt 3614641 tgcccattct atataatatt ggtcattaaa aagcatgatt ccaatcggca tttccatcaa 3614701 tgcctcttca ccgacttttt tcaacctgta ggacaacgta gaaatataag catcaatctc 3614761 ttgtcgaata agagaatcag cacgcttaat aaaaaacaaa ataactgcca gcagcagcac 3614821 ttcgacggtt cctaatatcc agttaaaata aaagctgatg aggattgtaa taattgacag 3614881 agcaatcaat gcatagatgg gataccgaaa cagcggtttt tcataaaagc ttggcatttc 3614941 tatcactccc caccatgtga gtaaaactca tgttcacttc accttattcc ttatatgaaa 3615001 gcccatatct aaaacgccta aaatgcgaat ggccgccatg aagaccggat gcacaaaccc 3615061 aagtatgaca gcaatcacag ccgcagcctt tggatattgt ttcttatggc aatagaaaaa 3615121 gataaatgat aaaccttgga tgaaaatcag aaacccgagt ataaactccc catttaaagc 3615181 gatagagtac agcatttggc ctttttctaa aggcaaaaat gaaagcatga caataatcaa 3615241 atacagtact acaacacttt gcggaaactt caactctcta aaaggcttta gattaggaat 3615301 atcgggggag aatcgcctta agagcggctt agcgataagg taactgagga aagaaaaaat 3615361 aactcctacc atcacaatag ctgttggaaa aagatattga acgataccca attgttcttc 3615421 catcagtttt aattgcttct caaactgccc agcattgccc gactgcttcg ctacagtttc 3615481 tacaatatca agagattgcc ggtattgtgt cattgcctca tcaatgatat tgatacccaa 3615541 aaactgaatg cttatcacaa aatagaagac aatactaagc atataaataa gagcgcccga 3615601 aataatggcg tgcccgggct ctttcctttt gaaaaaatgt cccatggcaa tgccggcgca 3615661 agctgacata aaagctacaa taagcccgtt aaaggacccg acaataaaaa caaccggaag 3615721 actgacagcg cccatccata tccctagctt caatccatgt ctgatcgtat acaagatcat 3615781 tggcagcggc agtgcaaata acagaattgt tccaatcaca ggaacataaa cgaccagaag 3615841 cgtaatgatc gcaaacagac tgattaaaat agcaccttcc attaaagctc tcgtttgttt 3615901 cacttagtca cctcgtatca tcctgaacat acgaatagaa aagagcagca taaacgactg 3615961 ctcttttgtt catcgctgca acatgctttg caccgaatgt ttttatatca tctctaaatt 3616021 ttacttttat attttaacat aagtccaaat cgcaagtaaa atgacgctaa tgtttcatgt 3616081 gaaacatgaa aaaggaaaag acattctttg aaaagaatgc ccatcacaat taatgtttat 3616141 catccataaa gccagaagat tccttgtttt tctttttcgt ttttctgaca tacataaaaa 3616201 ttaagatcac cagtaaaagg gttgttgctt gcagaacgcc gctgctaaac aagaaaaagt 3616261 tctttatcat gtcccacatt gtgtttcacc tctttgtgca tgttctcaac ccgtatccta 3616321 tataaggtga atttcccttt ttaaaaactt caaaacatca tgaacaacat tgagcgttgg 3616381 gcatatgctg atatggaatc tgatcgataa aggagaattt tcacatggat gaacgcagaa 3616441 cattggcttg gcatgaaaca ttagaaatgc acgagctggt tgcttttcaa tcaaacggac 3616501 tcattaaact gaagaaaatg ataagagaag taaaagaccc tcagctcaga cagctttata 3616561 acgtgtctat tcagggtgtt gagcaaaatt tgagagagct tcttccgttc tttccacagg 3616621 ctccgcacag agaggatgag gaagaagaac gcgcagataa cccattttac agcggtgacc 3616681 tgctcggttt tgccaaaaca tctgtccgca gctatgccat cgcaattaca gaaacagcaa 3616741 cacctcaatt aagaaacgta ctggtcaaac agctgaatgc tgccatccag ctgcacgccc 3616801 aagtttatcg atacatgtat cagcatggat attatccgtc ttacaacctt tctgaactgt 3616861 tgaaaaacga tgtcagaaac gccaacagag ccatttcaat gaaataaaac aagcagcaaa 3616921 ggagttccct ttgctgctat ttctgctgat ccttcactaa gccgttcgaa cgataagatt 3616981 ccagcacgtc tctgttggat tctccccatt ctttcatttg caaaacaatc ggttcaagcg 3617041 tgcgcccaaa ttccgtcaga gagtactcta ccttgggcgg cacctggtga taaacctcac 3617101 ggtgcacgat gccgtccgct tccagctccc tcagctggag agtaagcatt ctttgagtaa 3617161 tactcgggca gattcgccga aactcattaa atcgtttctt gccatctatc atgtgataaa 3617221 aaagaattcc tttccacttt ccgccaatga catctagagt gaattcaact ggacagcctt 3617281 ctttgttcgg gtatatattc tttttttcac tcattcttga ccctccaata gtaccttttt 3617341 tgatactaca ttacattttg caactaatct acccagtatt ttacacacct tttctcctta 3617401 gctcaaagaa aatgcttctt attcacatca atttttaagg gtttgcatga ttacacctgc 3617461 agcaagacgt gttaaactat ataaagatta cactacttaa aaaaggatag gagctatcat 3617521 ggaaaagata cttattttcg gacaccaaaa cccagataca gatacgattt gttctgcgat 3617581 tgcttatgct gatttgaaaa acaaactcgg cttcaatgct gagcctgtcc gcctcggaca 3617641 agtcaacggc gaaacacaat acgcgcttga ctatttcaaa caagaaagcc cgcgtcttgt 3617701 tgaaacagct gcaaacgaag taaacggcgt tatcctggtt gaccataacg aacgccagca 3617761 aagcatcaaa gacattgaag aggttcaggt tttagaggtt atcgaccatc accgcatcgc 3617821 taactttgaa acagctgagc cgctttacta tcgtgctgag cctgtaggct gtacggctac 3617881 catcttaaac aaaatgtaca aagagaataa cgtgaaaatc gagaaagaaa ttgccggcct 3617941 tatgctgtct gcgatcattt ctgattccct gttatttaaa tctccaactt gcacggacca 3618001 agacgtagca gcagcaaaag agcttgcgga gatcgctgga gtagatgctg aagaatacgg 3618061 cttgaacatg ttgaaagcag gcgctgatct aagcaaaaaa acagtggaag agctcatttc 3618121 tcttgatgcg aaagaattta cactcggcag caagaaagtc gaaatcgcac aagtaaacac 3618181 agtggacatt gaagatgtaa aaaaacgcca agctgaatta gaagctgtga tctcaaaagt 3618241 tgtggctgag aagaatcttg atctgttcct tctcgttatc acagatatct tagaaaatga 3618301 ttcacttgct cttgcaatcg gtaacgaagc agcgaaagtg gaaaaagcgt tcaacgttac 3618361 attagaaaac aacacagccc tcttaaaagg cgttgtttcc cgtaaaaaac aagtcgttcc 3618421 tgtcttaaca gacgcaatgg ctgaataagc aaaaagcatc ccgcgtcggg atgctttttc 3618481 ttattcaccc agcttctcaa tttgtcccat cacatcagta atttgctttg cgttttggac 3618541 caggtctgac tgctccaatt ctttaagcga taccttgcct tcctcggctt gtttcaacac 3618601 atcttcagcg cttttctgca aggtttcgtt atgctcctga atggttcgat gaatctccgc 3618661 tgcggcatca ggcggcgtta attcattaaa atcagcggca gccttctgaa tcgactcaag 3618721 ctgcgcttca agtttttctt tcgcctcggt gtcatttaca gctttctcag ccaattcagg 3618781 cgcttcctct gcaaatgtct tcaccttctc cacataacca gctgcttcac tcgtatagtt 3618841 caatccgtcg ttcacctgat caagcatgcc gcatccgcct gcactcaaaa gtcccactcc 3618901 ggcaagtact gtcaaaatga tcttcatctt cagccccctc atcgtttctt tttcattttt 3618961 tcttttaaga tcggaatcaa tttctctttc gctaacggca gccctttcct caccaattca 3619021 cgcttcagcc actttttcag cttagacatt ctgatgctcc tctccctttt tgataaaaat 3619081 gaaaaaactc caccaatttg gtgaagttcc tgaaacaaaa agaccttcac caaatcagat 3619141 ttggcaaagg tctcgctaac aatgagattg ccagcaaagc cgaggacacc ttgtcccgta 3619201 atgacgactt tactgtgaaa gctactcccc tttggagtgt tcatttttat tactttcatt 3619261 ctaaagcacc gatctgttcc agtcaaattc ctgccgttta tataaaagcg cgctgtggta 3619321 tttaaaattt gaatggtttt tctatcagga gatcatgcta tgacagagga ggttttcatc 3619381 atgagtcaag agcgcgtgaa acggcctggg cataccagat ggtacatatc ttcgttactt 3619441 agcggcatta ttattcttaa ttattttgac cgagtggcca tctcggtagc ggcccctgcg 3619501 atacaagatt cgtttcacct tactgcaact gaactcggca tcgtgttttc catttacacc 3619561 tattcctata cactgatgca gctgcctgtc ggaagtttgc tggaccgttt tggggtcgca 3619621 tgggtcacga gggttggaat gacaatatgg agctttttaa cgatccttct tgcttttttg 3619681 caaggaaaat tgctgttgta tctgttccgg tttctcattg ggctgacgag cgcctctgcg 3619741 ttccctgctg cctctaaagc aaccgctctc tggtttcctc caagtgagcg gggattggca 3619801 aactcactgt tcgattcggc cgccaagttt tcaaatgtaa tcggcgcgcc attggtcgcc 3619861 tttcttgtca caacatttga ctggcgtgtc gcttttttga cgattggatg catcaatgtg 3619921 ctgtttacga tctttttctg gcagtattat gaacagcctg aacggcacaa acgcatttct 3619981 aaaagtgaac taaactatat tcaaaaacac aatgccatta caacagagca aatcccttac 3620041 aaaacgggcc cgcttttaaa aaagcttttc accaatcgaa aagtatgggg cttaatgatc 3620101 ggatttacag ggtacgggta tacattcaac ctgctgctca cctggcttcc gactttcttt 3620161 aaacatacat acggtatgga tctcatgtcg tccggtttat ttacggcagt gccgtggctg 3620221 atctcaacca tttccggaat tgccgtcggc ggctggctcg tcgattattt tattaagaaa 3620281 ggctatccta ataccaaggt gtaccgaacc gtaatcatag tcggaatgag ctttggcttt 3620341 ttctttttag gatccattct gacgaacaat attaccgtag ccattatttg catttccatc 3620401 ggactcgccg gaatttccgc aaccgctccg gtcggctggt ccatctccgc agaactcgcg 3620461 ccgatcggtt ccgtatccat gctgagctcc atggtgaatc tcgcaaacaa cctgttcgga 3620521 ggcattattg ctgcgtcact gacagggtat ttgtttgatg tgacaggctc ctttaccctc 3620581 agctttctgg tagctggttt tgtgctgttg ctgggattgg ttttttatgt gtttgtatta 3620641 ggggatgtaa aacgaattaa actatagaac atgaaaaaga gagctgccag ttggcagctc 3620701 tccctttaca tcaaagaatc ggcccgtccc catttacctt ctcctcgtcc tgttcctcta 3620761 tatcaagccc cgaagctagc atttcctgct ctatctgttc gagcacctgc tcgttttttc 3620821 cttgaagacc accttcataa tgaaaagcat cctgtgtgcc gttttcctct attgtcgcta 3620881 aaatatcgtg gatatcatta tggtctcctg aaatggagcc gaatccctgg ttttgttttt 3620941 tataattcac aaaaccgctg gggaggttgt ttccgaggtt tacacatgat gcgctccgag 3621001 tagtaattca tcagtgtatc aaaatcttca ttttggattg ccacatcaca tgcagagatg 3621061 atgtctttca attgctgttc caaatgaatt cccctaatca tcatgattgg atatattata 3621121 caatgtttga cacgtaggga tccttttcat ttttgttttt acggtttcgc tggtccattt 3621181 ccgcagagct ggcgccgatc ggttccgtat ccatgctgag ctccatggta aatctggcaa 3621241 acaacctgtt cgaaggcatt attgcggctt cattgacggg gtattttgtt tgatgtgaca 3621301 aggctccttt acgctcagct ttctggtagc cagttttgtt ctgctgcttg gattggtttt 3621361 ttacgtgttt gtcttagggg atgtaaaacg aattaagcgg gaataaagag tgcttgtaga 3621421 gaaaacgttg ttctttctac aagcttttta gttttgtgct gtttttcaag atattcagct 3621481 gtcataaaaa gaaaatgagc tcccacatac cggctaggta tgtggcgttc ttcttcatgt 3621541 tctggcatgc agctgtgagg aggatttgtt tgctcacccc ctgaacctgc gatagctaag 3621601 cccgtgcagt tgttttgaac ctacaaagct tcgttctatt ttttcttttc tttttttaga 3621661 gatttcctga aatagaaaag caatcttttc taaccttttc tttatggttt tgccatacat 3621721 accgagtaac gactttctgg cgtttcgttg attttgtgta atattctcaa acatatttca 3621781 ggatttgatt tatatgaccg atagtctttg cgatcaattg ttgagtacgt aagtgtatgc 3621841 tgattcaaca aatgtatctg tattgttcac tttataatga aatttccatt ttggaagcaa 3621901 acccctgact gggtgataac gtctatgtgc gatggcacca aaaacttgga ggtcaaatag 3621961 tcctttagag atgagagttg ttaagtagcc ggaatctaga gcgacggctt ctacttgaaa 3622021 atcaaatcat gcaatttagt gatccaatcg gtcaaggtag ggcttggaac agaatcatgg 3622081 acttttctgg agttgcaaac tattaatcgt cctcattaaa tttataataa aaatattctc 3622141 aattgagcaa atcgcccacc ctttttcctt tataacataa aatccaatac tatcaataaa 3622201 attctttaca ggttattaca gttaagatat aatatagtta atcttttacg taaaaggagg 3622261 tttttattac ttgtgttgaa gttttaaata ggagtaactc catctcccca ttacggtctt 3622321 catttaattt catcctgagt tttatttagt tagatataaa aacgaaaatt tcacattatt 3622381 tttaactaac cgatagtata aaatatatat tgaaaggatt gtaaaattat gaataaattc 3622441 ctgaagagca atttccgttt ccttcttgcg gctgctttag gcatatcatt acttgctagt 3622501 agtaatttta taaaagccag caatgataac tataaattcc atttacttgt accttatggc 3622561 tatggtaatg cctattcaaa tgatgcattt agacagacca ctcatacaga taatccttgg 3622621 aaagtaaatt tacagaaatc ggcagaaggt aaaggtacaa tcatgacatt ttggttgatt 3622681 aacacaggga atagtaaaat tccaaaagct tctaaaatac ataacgtaaa acaaggaagc 3622741 ggagctcatt attatcatgc aaatagccag ggaagccata catatgtagc cttagcagtt 3622801 gaaaacaaca attacagtgc aagttcttat ggtatagatg gtgtatggga tgaagaaact 3622861 tggtaaacaa gaaccttcta aaaacgttgg caccttttag ccacgcgaaa aaatttagaa 3622921 tgataatctt tttataagat tatcattttt atttattcta ttaagaattg agtgagaaca 3622981 tggaaagtca tatttatcgc attatcaaaa ataaattaac tataataata tttactataa 3623041 tcatattaat tccttgtgtt gatatatcac tattgttaat gactaacaca gaataccatc 3623101 ctgcatatgc gtttttcctt tctggcactt ccgtagggca tgcttcacaa atgatcctat 3623161 tatggtttct tccgctttat tttttgttac tatgtgctga cgattctata caagattata 3623221 aaacaggata tcattacatt cttataagca aagttggcag aaaaaaatat tgtttggaaa 3623281 aaatatttac ctcttttatc atttcatttt tgacaatgtt tttgtcacta atattaaact 3623341 ttttattggt tcaggttttc ttttttaaag gtacatttaa aaatgactta gaccaaatta 3623401 aattccctga taacagcctt tatactttta gtatggccca tccttatata gcaattgtgt 3623461 tattttctat tatttgttgt attatgtctg gatttgttgg agcacttggt tcaagcctca 3623521 gtttactttt tcgtgataag aagtatgcct acccagcaag tttttttatt tggttcgtac 3623581 ttatactaaa aaacaaatca ttaatgtttt tattccaacc gtttacagaa tacggttata 3623641 atgtacttct ccctatccta tgtttgtcta tctttatttt tctaataata atttctagta 3623701 ttgttttata tgaggcaaaa tacaatgaaa attaaaagac tactattaat tttatgttta 3623761 ctactatttt tagttacttt atggttcaac cagaaccaca cttatcttgg aaagaattct 3623821 atcgcgtcat tactatatat gaataatagt acattcggat atagttcaat atttgcatat 3623881 accttgtttt atattgtccc gtttcttatg ttacttagta acttttttca ttcagaaaac 3623941 ccctacaaag taatgaggat ggttaagcgt aaaaattact acaagtctaa aattatggag 3624001 attgggtttg tttctttact tttttcttca atacatactg ttattaatat tacgtgtaca 3624061 catattttct ttagtaaaaa cttgttggtc gaagcaaact ttttatcaat ttgtttatta 3624121 aacatgatta gtttagtgtt tttctactta tcagtaggta ttatgtttag acttacatac 3624181 gatctgttta attcagtagc attagcaatt tttattgtgt atataatttt agatagcttg 3624241 tatttcggcg ttaaattatt acttcctaat ggatattggg aaccctttag agacttggct 3624301 atattcacaa atatgctcaa tagatattgg tcaacttcaa atcttataat agtttatatt 3624361 agacagataa taatagtttt tattttttat ttagttggat cttcaatttt tttgaataag 3624421 gattataaaa aatgaggatt aaaggctttt tcataacttt agttgcgata atatttcagg 3624481 cgtcattatc gagttataat aataataaaa atgtctttcc ttttttagat ggcataccaa 3624541 taagcacctc gggtcattat gagtatcaaa atattttatt gtggtttgta cctattgttt 3624601 ccctaagttt ttgtttctct gggagtatta gagatacata catttcgtat gagcaattaa 3624661 agttagtaag agaacatagt agagttaaat gggtaacatc tcaattctta ataattacag 3624721 ttgtactttt aatctttact ttatctcaga ttgctatatt ttatatttat tcacttgtat 3624781 ctcttcataa ccttgatatt aattccgtta tcaataaaag atttgttatg atgacactca 3624841 tgtattatct aaccttactt aacttattta gttttcaatt atttatggag ctttattata 3624901 aatctcaaat agcacaatta aatataagcg tttatattat tttttcgtta attttagcaa 3624961 agaagttagt gcaattaaat tctccgaaag ttattcacta ctttttaatt ccaaactaca 3625021 gtaatggatt aagaactggg ttaagctatt attcccaatc tggaactgct attattgaac 3625081 cattattagg tttgtttatt ataatcattt tacagatttc aatagttata ttatctgtct 3625141 taaagttcaa aaaaatagat atgctaaaaa gtgagggctt acaatgattg aggtattaaa 3625201 cctaacaaaa aaattaaaaa gactacagtt ttagataata tctcttatac atttgaaaaa 3625261 ggaacaattt atggactatt tgggagtaat ggttctggaa agaccatgct acttcgtgca 3625321 ttatccgggt taatagtccc tactgaaggg agtataacta ttaaaggtga acaattacat 3625381 aaagatatct cttttcctaa aagtgtagga ttaattatag aaaatatgca gttacttcct 3625441 cagtatgatg cttttactaa ccttaaaatt ttgtcaaaaa ttaaaaagat cgcatcagat 3625501 aatgatatat tagattctat tagtagagtt ggtttggaaa attttaatag tgtaaaggtt 3625561 agtaaattct cgttaggaat gaaacaacga ttaaatattg cacaggctat ttttgaaaaa 3625621 cctgatatat tgctacttga tgaaccaaca aatgcgattg atgaaaaagg agttgcattt 3625681 gttcatgaca ttcttttaca agagaaaaaa aggggagcta ccattattat tactagtcat 3625741 cacaaggaag atattatatc tttatgtgac attgcattag aaatgaatca tggacgtcta 3625801 gaaacttcag aaaaagtaat atataagaaa gatagttagt ttaaactggc tatttcttat 3625861 ccaatgatag actgcagaca agttcaactg ctgtaatgct agaaaatcca atgaaatgct 3625921 gataattgcg aagagatatg atcagtcaga aaacaaatct taaaaagaaa aagtaaattc 3625981 atcaatattt ctaataaacc tggcaaacaa cctgttcgga ggcattatag ctacttcact 3626041 gacgggatat ttatttgatg tgacaggctc cttacgctca gctttctggt gccggttttg 3626101 tgttgttgct gggattggtt ttttatgtgt ttgtattagg ggatgtaaaa cgaattaaac 3626161 tggaataaag agtgcttgct gaaaagcact ctttttctgc atcgaaagaa tacttaagat 3626221 aagtcactcc caaaaatcgt aacagtctga cggttaaaca taaacctctg cccgttccat 3626281 tttaatacgg tttgaacata tcccaatgag tcggcgttat accttcccgc tatccgctgg 3626341 tacgccaata attcgtatac gccgtctctg tcaaaatcaa ccggatacaa gcccgataaa 3626401 ggattcaccc atccttctat cggcattttt aacacacctt ggctgttata aatctcattc 3626461 aaatattccc tgcccttgta agtaaggtcg aggatatacg tttcgttttg ctgatgactg 3626521 ataacgctcg ctttatattg attttgatac ctcacactgt actttaattc atcattcaat 3626581 acatctgaat tgaaaattcg ccggaactgc ctgtttagat aggcaaacac atatgcataa 3626641 atagcaccgc cgcttccccc tgtgtccatt actactgcca catcctcaat cttgtcgcct 3626701 gtcatatccc ccagaaaaag tgacggattg tatcccatat tgttttgaag ctgaatccgc 3626761 tgctcctgat gggttctgcc atcacggatc accaatgtga tatttctcca taacgggctg 3626821 ccgggcattt gatttccagt tagaaagacc tcgtcaataa cgccgtctcc cgttacatcg 3626881 ccgcgggtag atacaatgat tgcacgtgag gagacaggct gccgaaatac gtatggatgt 3626941 tgaacaagtc ctctgccttc ataaaaccaa taaggagcca ttctgatgtc atacacattc 3627001 aattgtgtca ccttccctaa tcagctgaat gaatcattat atgcaggaat ggcacatcaa 3627061 agacatatct tacacaccaa ttaaatccgt accatatgaa ttatcaatta cacaaagcca 3627121 ctcgccttgc gcattctttt taaatacata ggtcgccctt ctttccatcg catactcgga 3627181 gtccttttta tccgaatcaa gcagtgtctg agaaagaacg agtaccgtgt cacctgcttc 3627241 caacaggatc attttccctt gtgtcgggac aatatgatga ttgaaatagt tcgcaatcgt 3627301 gataaacgct tttttgattt cttccttgcc tcgcgcgatc atgcccggct tcacaactaa 3627361 aacggcatct tccgaataat aattcatcag tgtatcaaaa tcttcatttt ggattgccaa 3627421 atcacacgca gagatgatgt ctttcaattg ctgttccaaa tgaattcccc caatcatcat 3627481 gattggatat attatacatc gctagaccac tgaaaccttg aaaacaaaat gaaaagtatc 3627541 cttttttcct atataatcaa atagatatat ttaacaaagt acccaagtga aggggtgaac 3627601 attattgtct gcggaagtaa cgttacatga caatatacat tatgatttaa gtgcggattg 3627661 ccagcactgt tttggcctgt gctgtgtcgc cttgccttat gcgaagtcgg cagattttgc 3627721 ttttgataaa gacgggggca cgccttgccg caacttacaa tcaaactatc aatgttctat 3627781 acataaagat ctcagagaaa aaggatttcg aggctgctct gcatatgaat gctttggcgc 3627841 cggccaaaaa gtatcccaaa tcacttatga gggaaaggat tggcgaaaca gccccgaaac 3627901 ggccaaccag atgtttgacg tttttcctat catgcagcag ctgcacgaaa tgctctggta 3627961 tttacatgaa gctctttcta tagatatagc caagccgatt cattctgaac tgagaaccac 3628021 tttcgaaaaa atagaaaggc tcaccagact cagcaaagaa cgcttgctga cactgcaggt 3628081 ggacgagcat cgagctgagg tcaatgaatg gctgttaaaa acaagtgaac tggtgcgtgc 3628141 ccaagcccgc catccaaaac tcccgaaaaa ggtcagccgg ggaagtgtcc tgatcggcgc 3628201 gaaactgaaa gggcttgatc tgcgaggagc aaatctaaga ggggcgctgc tcatagccgc 3628261 cgatctgaga aatgccgatt tgagaatgac agactttatc ggtgcagata tgagagacgc 3628321 tgatctcagc ggcgccgacc tgaccgggag catctttttg acacaggcac aggtgaacgc 3628381 cgccaacggc gattcgaata caaagctgcc gctgtctgta cgaacccctg cccattggaa 3628441 ataaaaaagg acccgctaac ggtccttttt tactgatcaa ttcaatcctt tttcgttcct 3628501 cttatccggc attttcacac ttcttgccaa gtatcccgac agccataacg caaccagcag 3628561 catgaaggtg atcataccga cgacgcccag ccagtgaaaa ccagaccaga atagccctcc 3628621 gattgttccg aaaacacttg aaccggcgta ataaaagaac aaatacagcg atgaagcctg 3628681 tgctttgttg tgaagggctc tcctgcccac ccagctgctg gcaactgaat gccctccgaa 3628741 aaaaccgaat gtaaagaggg caatccccag aattttcact gccagcatat tgtttatcgt 3628801 aaataacgca cctgcaatga cgatgaaaat attcatcacc aatattttcg gatagccata 3628861 ccgatcaacc attcttccaa tgaaagacga gctgaaaatg cctacaatca tcacaataaa 3628921 gatccagctg gaaaatgctt tattaagcga atacggcggg cccaacagca catacacaat 3628981 gtaattaaac aaggcaacat tgcttccaag cagcaaaaaa ccaatgagaa acaagctgaa 3629041 tagtttacgg tccctcaagt ggccgatcag agacattccc aatttcccga gcttcaattt 3629101 tcttggcgta aaatgcctgg atggcggcaa atttataaaa aatataacac tagcaatcaa 3629161 actaatgaca ccaattgtcc ccatcgccat atgccaattc aagtactcgc tcaggagccc 3629221 ggaaacgatc cttccgaaaa cggcgccgat tgcatttccg ctgatatata gccccatcgc 3629281 tgatccaaga cttccgggtt caatttcttc cccaagataa gccatcgcaa tcgacggaag 3629341 gcctgcgagc gcaacgcctt gaatggttct caatacgagc agtgtatgaa agctcggact 3629401 aaaggccgat gccagacaga gaaccgatgc ggccagcatg gaaataccca taataggctt 3629461 gcgtccccac acctcggata atgaaccaaa gacaagcatg ctcacagcta acagcattgt 3629521 ggtaacagat aaagaaagac tcgccgcagt aggcgttaca tgaaattccc gcgtgaattc 3629581 ctccatgagc ggctgtacgc aatatagaat cgcaaatgta ttgaaacccg cagcgaagaa 3629641 agcaaacgta atttttcgaa aaaccggtgt gccttttcga atgtatgtca tcgggacttt 3629701 atcggtccct catcatgttg tggagcactg ccattcataa acaatcatcc tttatttctt 3629761 acgaattcaa acatcctcga gtctgtttat attattatct tagcaccgtt gatatatgtt 3629821 gtataatgca tataaaatat ccttttcatg cttatatgta ataaggagag atgataattg 3629881 gaatgggaac aacttgaata ttttcaaaca ctggcccgga tgcagcacgt cacgaaagcc 3629941 gcaaaaagcc tctccatcac acagcctgca ctttcacgct ctatcgccag gctggaaaat 3630001 catttgggcg tcccgctatt tgacaggcaa ggacgatcca tcagcttaaa tcaatacgga 3630061 cacatttttt tacgacgggt tcaggcgatg atgaaggagt ataccgaagg aaaagaagaa 3630121 atccaagcct tattaaagcc agaccaaggc gtagtctctc tcggtttttt acatacatta 3630181 ggcaccacgc tcgtgcccga tctcatcggc tcctttcagc aggaataccc caacatttcc 3630241 ttccagctga agcaaaacca ctcttattgg ctgcttgaac gattaaaatc cggagatctg 3630301 gacctctgtc tcctcgcttc gattaagcct gaaaatccga tccaatggat caagctgtgg 3630361 agtgaagaac tctttgtatt tgtgccaaat gatcacccat tagccagtcg cgaaagcatt 3630421 accctgaatg agattgccgg ggagcgtttt attttattga aaaagggcta tgcgcttcgg 3630481 atgacggtcg atgagctgtt tgagaaggcc aatatacagc cgaacattat gtttgaagga 3630541 gaagaagcaa ctactgccgc aggttttgtg gcagccggtc tgggcatatc tattctccca 3630601 gacctgaaag gcttagacca aagcaaaatc accaaaatcc gcgtcagctg gccggaatgt 3630661 cagcgtgtca taggaattgc ctggataaaa ggcaggtttt tatcaccggt tgctgagacc 3630721 tttaaacaat atgtgatcag ccatttttct gagtaggaag gattcaagca tgaatgtcaa 3630781 aaaaatcacg tcagaacagg atttacatac agcgtttgaa atcagaaagg cagtatttgt 3630841 agaggaacaa ggctgtccca tttcggatga attcgatgag ttcgatacac tccacggtga 3630901 ctgccagcac atcctggctt atcatcagaa tgtacctgtt ggcactgcac gtgtccgtat 3630961 cgttggccac acggggaaac tggaacgaat ctgcattctg aagtcttacc gcaaattcgg 3631021 tttgggaaaa gtgatcgtcg atgcattaga acgtattgta aaagaacaag gcatttctgc 3631081 cttcaaactg cacggccaga cacaggcggc aggcttttat gaaaagctcg gctatcggac 3631141 tgcatcagaa gaatttatgc tggacggcat tccgcatgtg ctgatgacaa aacaagacga 3631201 ttctgcgcta tagattgttc acaaatttgt cacttatgag catgaacggt tcattggtat 3631261 actaatcacc gattatggag agaaggaatg attgtatgcc agcaaataaa aaagaaggcc 3631321 ttatatttgg cgtgatgatg tgctttggaa tggtttgcgt catgtcgatt tacaatgcca 3631381 tcatcaaccg agccatctac gatttttcac tgatgaccgt ttttgaaatg gtcatcggtt 3631441 ttatgatcgc cctcctgtta gatttactgt tagtgggccc cctcgccaag aagattgcat 3631501 tccgcatgcc gttcgacaag actaaaaaaa tttatgtcat ccttgccatg tcaacttgta 3631561 tggtgattgg catggtactt tgtatgtctg tgttcggttt agtgacagcg gttctagcaa 3631621 atgggctgaa cggggacagc ctcttcagtg cttatcttat gattgtgttg aaaaatttca 3631681 tcctggccta tccgttgcaa ttactgatta tgggcccatt agtcagagga gttttcatga 3631741 aatttgtaaa accaaagctc acagccgcaa tttaaataga aaaggagtga gcctgacact 3631801 cactcctttt gctcatgaat cgaatgtaaa acaagctccg caaaagcctc tgcggcaggc 3631861 agctgccatt ttttcttttt gggtgtgagt aaatcggatc gagggcttca ccatgctgga 3631921 gatttttcag cttatgtttt tcacttccat taatccctat accttaccac atagttttta 3631981 tacaattctt cgttataaag gatttcttcg ccatgtgaag agcaaatgag cgttggtttg 3632041 atttgatcta tgattgagcc gctgtcgatg ttctcattta tatcaacact gaatcttctt 3632101 ataggtgggt gtaaatcctc cttacttgtg ataaaaaggt cgcccgtcaa tagcgtacga 3632161 tcgattttat gataatacac aacatgcccc ggcgaatggc caggtgttaa atagtatttc 3632221 agaggcagat gagcaagcgt ttgctccgtc agcggctgta caatatgggc tacccctgtg 3632281 ttctccactt catttttgtt cggatatggc tcttccccat tgatgtactt tagttctttc 3632341 tggtgcgcaa aaatcggaat atcaaatctc tctaaccatt ttgatgcacc cccgatatga 3632401 tcactgtggc catgggtaag caaaatggct tttggattgc cgatcgctaa cgctgcccta 3632461 atttgagcat cagcaaaacg ttctattccc gtatcaacaa tataaacatc atcaccatct 3632521 ttgataaacc aggtatgaac cggaatacga agaggcacat caagctcaaa ttcacattga 3632581 aagacatgtt ctgatagttg tctcaaattc acgcaaacca tctcctgtgg aaattttttg 3632641 atagttttaa agaaaacaga agtgaacgga ctattttcac ccacgctcga gctgactgga 3632701 ttcttgagag gaaacgccga ttttcgccag catcagctca acttgttaac gttgtccatt 3632761 aataatccct tttgttcccc ttcttcacat attcccaatc acgttctata ttcttcctca 3632821 ctctatgaag gagtgcagaa atggtttcct tttcctctga agtaaaaccg gacaaggcca 3632881 cttccgtgga atgttctcct tctcttctta acaatggata tacctttttc cctttctcag 3632941 tcgggaacag tttttttatt tttttatttt gctcatccgg cagtttttga ataaatccct 3633001 gcatttccag cttcttaatg gcccgcgcgg ccgttgtccg gtccactttt atcatttccg 3633061 ccaatttttc ttgaataatt cccggatttt cgtatatacg cacgagatag agatactgcc 3633121 ctcttgttaa gtctaaatct ttaaattcga tgttgcttat ggaatccaac gctcttgcta 3633181 tcatgccgat ctcacgcaaa atatcattca ttcctaaaac ccctcacgta tttttgttgc 3633241 aattacaaca aaaatgtttt aaccttacta ttataagacc acatgcgtgc tgtacagtcc 3633301 agactaatat cagaaaagga ttgattcata atgaatataa aaagaataac aactgaagct 3633361 gatttacatg aagctttaaa gattagaaga ggcgttttca ttgaggagca acatgtgtct 3633421 gaagccgatg agttcgatga atttgatacg cttcaggaac aatgccagca tatcttggta 3633481 tatcatgaga atcagcctgt cggcaccgga cgcgcgcgca tcgttggcca tacagcaaag 3633541 ctggaaagaa tctgcatcct aaaaccttac cgtaagtacg gattggggaa gatcatcgta 3633601 agcgggttag aggaaatcat gaaagaaaaa ggactgactt catataagct gcatggtcaa 3633661 acacaagcgg caggctttta tcaaaaactg ggctaccaga tttcttcaca ggaatttatg 3633721 gaggacggca tccctcacgt cttgatgaca aaagaaatat cgcggaatat aacatgaaat 3633781 atatgtatta cggaataggc atactcatat taagtttggg catttcctta accatacaat 3633841 caggactggg cacatcaccc ttcgatgccc ttttggttgg tctgtcaaaa aaaatcggtc 3633901 ttaccgtagg aagctgggag gtccttattt ctgtgatcct cttaatctgc aacgctatat 3633961 taacgagaaa aaaacctatt ttgctgggct tgattacagc attcattact ggaataggca 3634021 ttgacctatg gttgtttgtt gtaaaaaaca ccatctatct aaactcgttg ttaagcaaac 3634081 tgatttgttt tggaattggt ttggtgctca tcggtcttgg aacagccatc tatcttcaga 3634141 cgaaattcgc atcaacaccg atcgatcatt taacacttat tatccgagat ctctccaaaa 3634201 gaacaatatt gttttcaagg acattggtat acgctctttt cttagtatta gccatcatct 3634261 ttaaaggccc tatcggcatc ggaactcttt taacggtttg tttgggagga atgctccttc 3634321 acgtttttat gcctattgtg gaaagacatt tcttatcaaa gaatagaaga ggttattaag 3634381 aaacctcttc tcgatccaaa aaacgaaacg caaaacaagc cccgtttcgt tgtcaattct 3634441 ttatctctgg tactgttgag gttttataat caattaaaat ttatagtacc aaaaaatcgc 3634501 aatttcattt gctgttggaa agttggaata aagcatcgta tcaaccgcac ctattataaa 3634561 gtgatgtttg gcataaaaat gacaagctga aatattaata tcttgggttt caagcataag 3634621 accacaaaaa tgattctcct ttgcccactc aatcgcttta tgtaataatg ctgttccaac 3634681 accttttttt ctatagtctt ttgccacggc aatgtcctct attagtgcat acccattcca 3634741 gttagaacgg atcttaatcc ggccaatgca gttgttttca agataatata aaaaagccgc 3634801 tttcccctct tcttcaacat aactaacatc catgtcatca tcttcatatt gtttaaaata 3634861 aggtttagaa aatcgttcct cagtatatgt ccaaacaccg ttttcaaaag caggtatcat 3634921 tctcccaaaa acaacgaaag gttcgtttgg tttattgaaa tctttcatat tcaaatgagt 3634981 cattttcatg atcatatcaa tctccgccaa tcgagataat atttagtaaa ctcgtttcga 3635041 tactattcaa caacagcttc caaaagtgta ctctttaaga gaacagcatt agataaggca 3635101 tccattacct tatatatttc actatcttaa tgaggtattt caacagaggc ttgtggtaca 3635161 gtaaaaagga atagaaacaa gagaaaagaa gatgaaccta tgcccactaa caataaactc 3635221 aatgagaaat atcatacttc cttcaactcg cccacaaccc tgttgactag tatccgtgga 3635281 gagaggaagc tttgacacag cttctgccat tgatgacatc tctattgaag tatccaaagg 3635341 acaaccaagg atcgctcttt gactttttca agaagaaagt agagtgaata aaggagtgat 3635401 tgagtatgtt aacaagagaa gatatcttta aacacgtcaa agaaaaatac ggtacatcgc 3635461 ctgattaccc gtgggagaaa tacccaaact atgcttcttt gagacataca tcaaacaaaa 3635521 aatggtacgg tcttatcatg aatgttctcc cagaaaaatt aggcttggat ggtcatggcg 3635581 aaatagatat tctaaatcta aaatgtcccc ctgaaataag tgatcgctta agaaacgggg 3635641 aaaatatctt acccggatat catatggata aggaacattg gatttcaatt gttttagaac 3635701 ggacagatcc agaaggcgaa atctataact taatcgagca gagctttcat ttaaccaagt 3635761 gaagataaag agtgttcctg ctaatcaagc tgcgaagagt agtgggcact ttcattttag 3635821 gatactgttc ttcactctgt ccacaaacgc aacttagttc atctggtgcg agagtgggag 3635881 aagaatttca accaacttct tatgtaaaag gatgaatagt tatgacaaat aacttaaaac 3635941 agagaagaat cattttagat ttagcagtta ctttagatgg ttttattgaa gggaaaaatg 3636001 gagaagttga ttggtgtatt atggaccctg atatggggtt tactgatttt ttaaatcaaa 3636061 ttgatactat tttatatggt agaaaaagct tcgatttatg gggacaatac attccaaaaa 3636121 atgaagaccc tgatacagaa aaggaacttt ggaaattggt tcatagtaaa aagaaatatg 3636181 ttttttccag aacacaaaat gagattgata atcaagccat atttataaat gataatattc 3636241 ttgaagaagt aaataaattg aagaaaaatc ctggtaaaga catctggcta tatggtggag 3636301 cgagtctcat tacaactttt ataaatttgg ggcttgttga tgaatttaga ttatctattc 3636361 accctgttgt tttgggagaa ggaaaaccgt tgtttattga tgtaaaacag aggataaatt 3636421 taaaaatggt gaatacaaga acattttcct ctggcgttgt gcaaatcgtt tatcattgga 3636481 atggctaaca ttgtaaagta acactcgaca gtaatccttc ttattgaact aaaggggaat 3636541 ccataaataa tgggttcccc ttaatatact atggaattat caatatcaaa ttttctgtaa 3636601 taaaagagga ttgaaaagga cgatgtctcc tcaattaaca tcattaagca ttatagtata 3636661 ttttcttctc cctcttttaa gtaatcggct aagttttgta tttataaaaa aacgaaagaa 3636721 ggtgatccaa tgcctactaa caataaaccc aatagattaa tcgctgagaa atctacttat 3636781 tttacttcaa catgctcata accctgtgga ctggttccct tggggagaag aagcatatga 3636841 aaaagcgaaa cgcgaaaaca agcctgttct cgtatctatt gggtatagct aacgatggct 3636901 aatctaaaga acatgctatt gatgccatgt ttattcattt tacaaaaaag gatcaacctt 3636961 gaattacttt cacaagattg atcctttcac tcatttagcc atgtctccgc gaacgtttat 3637021 atacattcaa gattactagc caacaaataa caatgattcc tgcaaaaagt atgagcatat 3637081 tgctatacaa ataggtagag tgatcaacgt caataggcag cagcctatga tctaggaagc 3637141 cgatagataa taaaccgcct acaatcgcaa tacccgttcc ctctgataaa aagctcgtga 3637201 aattaagcaa actcattcca gcgcccgctt ccttttcttt caaactgcta gacacaactg 3637261 tagatataac tgtttttgtg aaagatagcc ccccaaaaac aaaaattact ataattgtca 3637321 tgatccatgg tgctgcatct ataaaaaagg cagcgattaa aaagccggaa gaaagcaatg 3637381 cacttccaat agttagtaca tacaaggaac ctttccgatc aacaagcaat cccccaatgt 3637441 aaccaaagat gatgacactc attgttccgg ggaaaataat gccgcttcca attgctgcag 3637501 tacttaaatg gtgaacatct ttcatcatgt aaggaaccat agagacaaat cctgctactg 3637561 taccaaatat tagtcctccg caaagggttc caatcacaaa aaagacgttt ttccctaatt 3637621 cagggtcaac aaaagggtcc tgagctttcc taatgtgttg cacaaatatg aagaaagcaa 3637681 ggatactgat gatcagaaaa gaaaatctat aagatgttgt aaacagcata aaaaatacga 3637741 tacctgcaga catcaatata atccctgcca tatcaatgtg tcctcttatt ctctcttcct 3637801 ttttcaacaa ttttataagg aatggaacgg tgataattgt tgcagttgga ataagcagca 3637861 aatacgacca atggatataa tgagcaacca ttccgccaat agctggccca acaccttctc 3637921 ccattgctac cagggacccg atcaggccaa atgctttccc cctgttctct tttggaatat 3637981 agcgcgcaac gacaaccatc acaagagctg ggaatgcggc tgcaccaatt ccttgaataa 3638041 atcgggctag aatgagaata ggaaagaaag agtgtccaac aaatccaatg atcgacccta 3638101 agccatttac cataatccca aatagaagca gatttttgat gcccagctgg tctgatagct 3638161 ttccatatag agctgttcca atggagaagg ttaacataaa ggctgtattc acccagtttg 3638221 cacttgctgg cagtttatta aactcgttgg caatatcagg taatgagacg ttcagaacca 3638281 tttcatttaa tacgctgaaa aatgatagaa cacaaagcca aatcaaaact tgattgtgcc 3638341 gtaaagttga ctgtgaataa gacgtattca caatttcccc tccattaatg agggcagacg 3638401 cagtttatag ggtcattgat acgcttccct cttttaattg taccctgttc attttattgc 3638461 acttcataat aactccccct acatttgatt gatatgatct tattatatat agactaagga 3638521 ttaaactttt acttttttta taaaaatttg accagattgc gaaacaagga aaaacgttat 3638581 tcgcatttat ctcaagtggc aaaatgaaac attagtttat attttcacat cacaattatc 3638641 gataagcagt cagttattgt atttgtttag gataactgtg gtaacctgaa tataaccaac 3638701 ttaggaagaa ggtgatccca tgccaaataa aagtaaaccc aatagattaa tcgctgaaaa 3638761 gtctccttat ttactccaac acgcccacaa ccctgtggac tggttcccgt ggggagaaga 3638821 agcatttgca aaagcaaaac gcgaaaacaa gccggttctg gtcagcatcg gttattcgac 3638881 gacttgtcat tggtggcctg ggataatcaa atcgtgtgga actccattaa aagataacag 3638941 aagccatttt aaacgataat actatttgtt caaacaatac agtctacctt ttatttcatt 3639001 cattttctaa aacctgtaat ccgtaaccac gcggtagcag gtttttttat ttgcttgact 3639061 tagagttaac tctaaattgt aaactaactt taattaaatg agagggatga tgttgttgta 3639121 ttccattagt aaagctgctg agaagactag tattagttcg tatacattaa gatattacga 3639181 aaagattggg ttacttccac caccaaaacg aaaaaacagt ggaaggcgtt tttatacgga 3639241 gactgatatt cagttcatgt tattcctgaa aagtttaaag gaaacaggta tgtctttgga 3639301 ggatattaat gagtttgtca aagacggatg cattttggaa aaaatcaatt cggatgttaa 3639361 atcggcacaa ctctccccat ctataaataa acgtattgag attttaacca agcacttaga 3639421 gaaaatggaa attaaaaaaa gggagctgga agaagtgatt tctactacaa aaggaaaact 3639481 ggatacatat tattcaattt tgaaagagga agtggaaaac aaatgaaaca tttaaatata 3639541 tacataatgt tacttggctt ctctattttc acgggagcta cttttaatct tgcaaaatat 3639601 acagttggat atttttctcc atcgtcttct gcggcatggc gtttcggttt agcggctgca 3639661 gtgatgctca tcattttgat ttttactgaa ggtataaaga agagtcaatt acggaaaaac 3639721 gccgtttcat acattgttct tggaattata ggaatctttg gatttaatgc cttgtttttt 3639781 gttggtttaa aatatacatc tcccgttaac ggagcattaa taatggggct gaatccttta 3639841 ttaacagcaa ttctcgctcg aattatctta aaggacaaca tgacaaaaaa acaagtactc 3639901 ggcatattct ttgcattcat cggtgtattg ttagtcatta cacaaggttc tatcgaaacc 3639961 attaaaacct tatcaatttc aggaggagac ttaataatct ttacaggtaa cgtttgttgg 3640021 gcactttatg gcgtacttgg acgtcggttt gtaaaggatg gtacaccgct atctacaacc 3640081 acttatacga tggttattgg tgctgttagt ttaatagtag tttccttatt tacatccaaa 3640141 cctgtttctt tatcgaacat cccgattgga gtttgggggg caattgcttt tatggctttt 3640201 tttacaagtg ttttgggtta cctatggtgg aatcagggga ttaaagagat tggagctagt 3640261 aaaacatctt tatttttcaa ccttgttccc gttgtaacga tgattatttc atttgccgtt 3640321 ggaacaccaa taaaggtatt tcaagttatt ggggctgtgc tagttatatt aggcgtttta 3640381 accgcttcgg gggtaatacg tattcctaag tacaatacta aagaacagtc agctatataa 3640441 agaaataggg agtatttttg agaaaatgtg ttaagttaaa tatacactaa ttataggaag 3640501 aaggtgatcc catgccaaac aaaagtaaac ccaatagatt aatcaatgag aaatcaccat 3640561 atttactcca acacgcccac aaccctgtgg actggttccc gtggggagaa gaagcttttg 3640621 aaaaagcaaa acgcgaaaac aagccggttc tggtcagcat cggttattcg acttgtcatt 3640681 ggtgccacgt gatggcccac gaaagctttg aagacgaaga aatcgcgcgt cttctcaatg 3640741 aacggtttgt ggcgattaaa gtcgaccggg aagagcggcc tgatgtggat tctgtttata 3640801 tgagaatctg ccagctgatg accgggcagg gcggctggcc gctgaatgtg tttatcacgc 3640861 ctgatcaaaa gccgttttac gcgggtacat attttccaaa gacgagcaaa ttcaatcgtc 3640921 ccggttttgt tgatgtgctt gagcatctgt ctgagacgtt tgcgaacgac cgcgagcatg 3640981 tcgaggatat tgcggagaac gccgctaaac atttgcagac caaaacagct gcaaaaactg 3641041 gtgagggcct tagcgaatca gcgattcacc ggacattcca gcagcttgcc agcgggtttg 3641101 acacgatcta cggcggtttc gggcaggcac cgaaatttcc aatgcctcat atgctgatgt 3641161 atttgctacg ttatgatcac aatacagggc aggagaacgc tctatacaac gtgacgaaaa 3641221 cattggacag catggcgaat ggcggcattt acgatcatat cggctatggg ttcgcccgct 3641281 attcgaccga tgacgagtgg ctcgttcccc actttgaaaa aatgctgtac gacaatgcgc 3641341 tgctgctgac cgcttataca gaagcctatc aggtcacgca aaacagccgc tataaagaga 3641401 tttgtgagca gatcattacg ttcattcaga gggaaatgac tcatgaagac ggaagctttt 3641461 tctcggcttt ggacgcggac acagaaggag aagaaggaaa gtactacgtg tggtcaaagg 3641521 aagagattct aaaaacgctc ggggacgatc tcggaacgct gtattgccaa gtgtatgaca 3641581 tcactgaaga aggaaacttt gaaggcaaaa atattcctaa cctcattcac acaaagcgag 3641641 aacaaatcaa agaggatgcc gggttaaccg aaaaagagct cagtctcaaa ctcgaagacg 3641701 caagacagca gctcttgaag acacgcgagg aaagaaccta tccgcatgtc gatgataaag 3641761 tgcttacctc atggaacgcg ctgatgatcg cgggtcttgc gaaagcggca aaggtatacc 3641821 aggagccgaa atatctcagc ctagcgaaag acgccatcac atttattgaa aacaaattaa 3641881 tcatcgacgg ccgtgtgatg gtccgatatc gtgatggcga agtgaaaaac aaaggcttta 3641941 tcgacgatta cgcttttctc ctatgggctt atctggatct ctatgaagct tcgtttgatc 3642001 tttcttattt acaaaaagcg aagaaactga cagacgatat gatcagctta ttttgggatg 3642061 aggagcatgg cggattctac ttcaccggac acgatgcaga agccttaatc gtacgggaaa 3642121 aagaagtgta cgacggcgcc gtgccttcag gaaacagtgt ggcagctgtt cagctgctgc 3642181 gtctcgggca agtcacaggc gacttatcac tgatcgaaaa agcggaaaca atgttttccg 3642241 tgttcaagcc agacatagaa gcgtatccga gcggccatgc tttctttatg caaagtgtgt 3642301 taaggcatct gatgcctaaa aaagaaatcg tgatttttgg cagcgcagac gatccagcca 3642361 gaaaacaaat tatagcggag cttcaaaaag cctttaagcc caacgactcc attctggtgg 3642421 cagagcagcc cgagcaatgc aaagacattg cgccatttgc agcagactac cgcatcatag 3642481 acggcaaaac aaccgtttat atttgtgaaa acttcgcctg ccagcaaccg acaacaaata 3642541 ttgaagaagc gatccacaca ttaataagca gcagggatta agacccttgc tgcttacttt 3642601 ttgatttctt atggtaccat aaagcgatcc ccgcaaacac aaggttgacc gctatcgtaa 3642661 agaaagcctc ccacatcggg ttcccccgcg taacggtaaa cagagaagga attcctccat 3642721 acacactgtt tttttctgta ataaacatac acaaaaacat attattcgcg gcatgggcgc 3642781 caagtgatat ttcgatgctc ccagttttaa tcgtgtaata cgtccacaca aacccaaatg 3642841 ttaagtactc aattcctgcc cagacagcgc cattgttcat ttctggattc gcaaaatgca 3642901 atacgccaaa caatcctccg acaatcagtg tcaaaaatag aggatttttc gtcaatctcc 3642961 cgaaagcttg aagcaaaaat cccctgaaaa atagttcctc agctgatgtc tgaatcggaa 3643021 ccaaaatgag ggcagccgct agcagccaga taaatcgtga tgcattaaac tcttgcattg 3643081 aatagctatc aggatgaatc acaaaatcaa tcaattgtac ggcgatcatt agcaagaaat 3643141 aagcaataaa accaaaggaa attctccgcc aattcatctt tgaatttggt gttatcaccg 3643201 ttcggaaagg ccgcttcaaa ataaagcgca cagccagcca aactcccgga atggcgaata 3643261 aataaatcac atgggacaaa taaagatcta cgaggggatc actcagcaca gcttcatcca 3643321 aatcaaacgt gatattggga ttcacaataa ccgtgaacaa tatagcgaaa aggtaagcta 3643381 tattccctaa tacatataac cctaccatca ccaaaaaagc gaaaaaatat ctccacaacg 3643441 tattgtttcc ttctatagga cggataaatg aattcattcc ttctatgtct cttcctttca 3643501 atgagaatat tactatatat ttgcataaat tggtctatga atctactgtt ttggaaatct 3643561 tttaagcaaa attaaaatat aaagtgtgaa tttagttctt ccatctagtg atttgaactc 3643621 tgttgccaat gaaccaagat acttataata gtcccaagag gggaattttc agtcttttct 3643681 actactcaaa agggggtttt ttatgaatac gatcttcaaa caaaagaata cacatccttt 3643741 ctcaaacgca gcgaatcgtt tagaccgcct tccgatttca cgcgttcatt tccaagtgtt 3643801 aaccgctctc ggcattgttt atttctttga tctcgcagat ttatttaccc tcagcaacgt 3643861 agcgccggca ctgatcgagc attggggcat cccgctttca actattgcta acgtaacggc 3643921 cgcttcgttt ttaggcatgt ttttaggcgc ttcactgggc ggacggctgt ccgatcgaat 3643981 cggccgcaaa aaagccttaa atctatttgt ctttgttttc tcaatcgcat cgctatgcaa 3644041 tgctgcggca tgggacattc catctttaat gacattccgt ttcctcaccg gatttggcgt 3644101 tgcagccgcc atggtcatta cgaatagcta tttggcggaa tttttccctt caagtgtacg 3644161 tggaaaatat atttcttttt gtgccatgat tggattgatt ggggttccga tcaccaacat 3644221 tgtgtctgcc tttgtcattc ctcttggttc atggggatgg aggctagtat ttgtatgggg 3644281 tgccgtcggc cttatttatt ttttcttcat ccaccgtctg gaagagtcac ctcgctggca 3644341 cgaaaatcgc ggggaatatg cgaaagccga tgcgatcctc acccgaattg aagaacaggt 3644401 tgaaaaggag aaaggcccgc ttccggcagc atcccagcct aaagtaagcg aaactgttaa 3644461 gcagaatgca ggttacgcag gcttattgaa aggcagaaac ctcaaaatta ccatcgtatt 3644521 atctgctgta tggatttttg aaacgtttgg gttttacgga tttgcttcat gggttccaag 3644581 cctgctaaaa agcaatggcg taaccatgga aaatacatta tggtataacg tattgcattc 3644641 cgtcggcgct ccacttggcg cactgctcgg ctccatgatt tccgaaagat ttcaaagaaa 3644701 atggatttta gctgcgagtg cgtttctgac ggccatcgcc gggctcttat atggtatgac 3644761 ttttattccc atcatgatca ttgtatttgg ttttatcgtg aatatcacag aacgggtctt 3644821 tacctcgaac ttatacgcct atacatctga accttatccg actgaatacc gctcgtctgg 3644881 cagcggttta gcctatggtc ttggccgttt ttcaaacatt tttggctcat tgcttgtcgg 3644941 atttattgcc gttcagctcg gctatatcag cgtcttctta tttattgggg gctgttggct 3645001 cgcatgctcc ttgctgttaa tcttcttcgg tcctaatacg aatgcaaaac agatttaaaa 3645061 aagtcagtgc ggatctgccg cactgatctc attacaattg cttcaaaatc cttgcggggt 3645121 ttccgcctac aacagtatta gcgggtacat ccttagtgac aacagatcca gaagcaatca 3645181 ctgcgttatc accgattgtc actcccgggt taatcaccgc ccggcctcca atccaaactt 3645241 gatctccaat tgtcacaggc ttaccgaact ccttcccgga tttcctttcg atcggatcaa 3645301 gaggatgacc ggccgtgtag atatgtacac ctggcgcaat caaacaatga cagccgatac 3645361 gcacctcaca cacatctaaa atgacacagt caaaattaac aaatgtatga tctccgatat 3645421 gaatgtgata gccataatca cagcggaatg tcggcaaaat cgtgacttga tccccaaccg 3645481 aaccgagcag ctccttcaaa agcttcgtcc gcactgcatc atcttccggt gtttcgttgt 3645541 attgtctaat cagctgtctc gcatgcttgc gttctagtaa tagttgttga tcttccgaat 3645601 tgtataattc tccggctgcc attttttctt tttctgtcct cagcatttaa gtcactccag 3645661 atgtcagatt gtaatctcga tcaaatttcc ttcatcatcc tcaatcacgc tttcatagta 3645721 gccgtctcct gttgtcctcg ggccgtttac tactgcgaaa ccatccgcct tcaatcgatc 3645781 agtcagttcg tcaactttct cccggctccc aacggaaaag gcaatatgtg cccagcctgt 3645841 cattgtttgt gagggcggat cggtcacatt cccttttttc ataatttcca gccttgctcc 3645901 ggaatcaaac gtaataaaat aagacttaaa atcttttttc tcattatgat acaaatcatt 3645961 cgcttcgcca ttaaaatacg attcataaaa agacttcatt cgctctaaat cattgaccca 3646021 gaccgctgta tgttcaatct gcatttcttc ctcctccttc gccttcaatg aagttataag 3646081 gtatgaaatg catttcagtt caagcttttt tcttaaattt atgctgaatt ttgatatcag 3646141 cgggttcatc ctgcaaaaat agagaaaatg ctgcgatgcc gagctgctca agattcaaat 3646201 caagcgacgg aaaaccaaga acacggctga tagaagtatt tccctcgcct atgatttcaa 3646261 catcccaatt attctttttg gcaaatagat gaattccagc tgccacttca tcactatttg 3646321 cataaatagc agtcggaacc cgcccgctca tataaaaatg ttcagctgcc agctcaccat 3646381 cattcatatc gttgcatccg gacagcatat ggcggtcttc caaccttccg cagacagctt 3646441 tataggccgc agctttatca gccgtgctcg ggctcctatc agcttctctg acacacgtaa 3646501 aagcaatatt ctcatgcccg cggctcttta aatagcgaaa gctctctgca taagcagttt 3646561 ttctgtcatt aaaagcacaa gggacatcaa tgtctccggt atcctcacaa gcgatgaccg 3646621 gcccatattc ctgataagct aaaatgctgt cccaatgatt ggcgcgggaa gtaatgatga 3646681 gaccgtctat tttcttcgtt cttaacagct ctaaatattt gatttcaata tcggggttat 3646741 aattggtggg gagaagggtc gttgcatact catgctgaaa agccgccttg gtgattccgt 3646801 taacgatttt atcaaagcag ggatgatcgc tataaggcag aatcacaccg accgtatggg 3646861 ttttcccgcg aatgagatcg attgcggttc gatttggtgt ataatccaat tccttcatga 3646921 cttgatgaac aagctttctc ttttcttcag atacatacgg atgatgattc aatacacgcg 3646981 agacagtcga aacagataca tttgccagtc ttgcgatctc ttttatattt gccatctctt 3647041 tctccttttc atataaaaaa agcagtaagt gtaaaatcct tactgctatc tcatcatata 3647101 ttgatgataa gttcaacagg acaatggtcg gaacccatga cgtccgctga tatgctggca 3647161 tcttcaatct gttccttaag gctttcagaa acaacaaaat aatcaatccg ccatccaata 3647221 tttctgtccc gggcgccggc acgatacgac caccaggaat aagcgccttc aagatcagga 3647281 taaacatgac gaaaagaatc aacaaagcca gcttctaaga aacgagtgaa tgcctctctt 3647341 tcttgatctg aaaatccagc gttattccgg ttcgcctttg gatttttcaa gtcaatctcc 3647401 tgatgggcta cattcaaatc accgcataaa atcactggtt ttttctgatc caattcaaga 3647461 atataagaca gtaaagcctc ttcccattgc atgcggtaat caatccgctc taatcccctt 3647521 ctggaattgg gcgtgtaaac agtcatcaca aacacgtttt caaattccag cgtaatcact 3647581 ctgccttctt ggtcatgctc ttctactccg ataccgtaga tgacctgcag cggttcttgc 3647641 ttagaaaaaa cagctgtgcc ggaatatcct tttttcactg cataattcca gtacacatga 3647701 tagtcttcag gctggagatc aacctggccg tcctgtatct tcgtttcctg aagacatata 3647761 atatctgcat cctcttcttt caaataagag aggaaatcca tttttctcat cacagcccgc 3647821 aggccgttta cattccatga aatcaacttc atgtttcatc ctccccccta taaaaaagag 3647881 caagaacccg aaggtccttg ctctttacat atcagcttac tcaccgctta cgtatggaag 3647941 taaagccatt tgacgtgcgc gtttgatcgc tgcagtcaat ttacgttggt atttagcgtt 3648001 tgttccagtt acacgacgtg gtaaaatttt accgcgctca gaaacaaact ttttaagaag 3648061 atctacatct ttgtagtcga tgtgcgtgat accgttagaa gtgaaataac acactttacg 3648121 gcgtttcgca cgaccgcctc tgcgtcctcc tgccattgtc atttccctcc tttctttttc 3648181 attttaggcg ataatcacat tagaatggaa gatcatcatc cgagatgtca atcggtttgc 3648241 cgtcgttggc aaatgggtca tcattaaagc tgttcccctg attgcgtctc tggttgtttt 3648301 gatttccccc aaatggatta tcattttggc ctccgccaaa gtactggcct ccgccgctgt 3648361 ttccttcgtt gtatccacct gaaccagaac cgccgccgtt tttcggctca agaaattgaa 3648421 cactttcagc ttggacctct gtcacgaaga cacgctgtcc ttgctggttt tcatagtttc 3648481 ttgtttgtaa acggccatct acgcctgcaa ggcttccttt tttcaagaag tttgcaacgt 3648541 tttcggcttg tcttctccaa gtgacacaat taatgaaatc ggcctcacgt tctccggact 3648601 ggttcgtaaa tgtacgattc acagcaagag taaacgtagc aacagccgca ccgtttggcg 3648661 tataacgaag ctctgggtct tttgtcagtc ttccgactaa tacaactcgg ttaagcataa 3648721 gaaagaccac cttttaccat tatatatttc aaaattgctt attcttcttc tttaacaaca 3648781 atgtggcgaa tgatatcgtc actgatctta gctagacggt caaattcttg aactgccgca 3648841 gcgtcagatt gaacgtttac gatttggtag aaaccgtcgc ggaaatcgtt gatttcgtaa 3648901 gcaagacgac gtttacccca atcctttgtt ccagtgatct ccgcaccgtt agaagtcaga 3648961 acgttgttga aacgctcgat aactgctttt ttagactctt cgtcaatgtt tgggcggata 3649021 atgtacataa cttcgtactt tctcatctgt ttgcacctcc ttttggacta agcggcccat 3649081 aatgggcaag gagcaataat tctattactc acaattttat attataccaa agctcttgtc 3649141 cctttacaac tgcatcctat acattaaatc ggaaatgaat aacatctccg tcttggacca 3649201 catattcttt cccttcaagg cggacttttc ctgcctcttt agctcctgcc ataccgccgc 3649261 ccgcaagaag atcctcataa gcaactgtct cagcacgaat gaagccccgc tcaaagtcac 3649321 tatgaataat tcctgcacac tcaggggctt tcatgccttt tttgaatgtc caagctctga 3649381 cttcctgttc tccggctgtg aaatatgttg cgaggccgag aagagagtaa gacgctttga 3649441 tcagctgatc aagacctgat tcttgaatgc ccagctcttc caagaacatt tgcttttctt 3649501 cgccttcaag ctcagcgatt tcagattcga tttttgcaca cacaacgata acttctgcgt 3649561 tttcgccggc agcgtactcg cgaatcttcg ctacattttc attgccagat ggatcagcaa 3649621 cttcatcttc acttacgttg gccacgtaca aaataggctt cgaagtcagt aaatggagct 3649681 gcttcacaag cttttgctgc tcttcagtga attctacaga tcgagcaggc ttttcactct 3649741 caaacgcttc tttcagttta gataaaatct caaactcaaa tacagcgtct ttatcttttt 3649801 gcttcgcaag cttgctgacg cgtgtaatcc gcttttcaac tgtttccata tcagcgagga 3649861 tcagctcaag gttgatcgtt tcaatgtcat caatcggatc aacctttccg gaaacgtgtg 3649921 taatgttgtc atcggaaaaa gcacggacaa cgtggcaaat cgcgtcaact tggcgaatat 3649981 gagataggaa cttgttgccg agtccttctc ctttagatgc gccctttaca atccctgcaa 3650041 tatcagtgaa ttcaaaagca gtcggcacag tcttcttcgg gttgaccagc tcagtcagct 3650101 tttgcagacg atcatccggc acctctacaa ttcccacgtt cggatcaatt gtacagaacg 3650161 ggtagttggc tgattcggca ccggcctgtg taattgcgtt aaatagtgtt gattttccga 3650221 cgttcggcaa accaacaatt ccagctgtta aagccattct ttcatctcct ctatataaaa 3650281 ccgtcattgt atgaacgtat tttgaaccta gagcaattat aaggaggttc actggaaaag 3650341 acaagctgac aaaaaagcat tttcagcttg ccaatccctt tgattatgct tttttcaagc 3650401 ctactaaaca gtcaaaaagc gtacttccca ttccattatc agaatttgta tcatttgtca 3650461 gtgcattgac tgaccctcca aaagccgccc acatgccttc atctatatta atcgtcttcg 3650521 catgagcctg cttcatcact ttcaccttgc ccttcatgct tccgcggtca ttaaagatga 3650581 caacttcgtc tccatcctga agatcctgcc cagccgctat atctggagaa atatcgacct 3650641 gaacgtgctg aagcttttca ataaacggca catgctgtga atgattggaa cgctgcggat 3650701 gaatggataa gagcgtataa gggtactttc cagctaactc ctcattatgg aaaacagatt 3650761 cttcgggcac atttaattga agcgagccgc taaatccttt ttgctcagct agcgacgaag 3650821 taaattcaaa ttttccactc ggcgtcaaaa actgataatc atcccacggc acctgtttta 3650881 ctggaagagg gaggtggcct ttttctttta aacgctcaag tgtcacatcc tctgcttcca 3650941 atgaagaaag ccccatctct aaaaattctt gagtgctgta ttcaaacagc tcgccaaacc 3651001 caagacgttt tgcaagctct gaccagatcc agctgtccga tttcgcttca ccctgcggct 3651061 ccacaagctt cttcccgtac tgaacataat gatgatacat actggaatag tagatatctt 3651121 cttcttcaaa aacagtggca gtcggcaaaa cataatcaca cagctctgcg gtatccgtca 3651181 taatggaatc aatcgcgacc gtcattggaa ccttttcaaa tgcttgtctc accttatttg 3651241 tattcggcac ctgagtcagc ggatttccgc acgtcacaat aatcatctca atcgcaggat 3651301 cagcagcggt caacacttct tcagcctgtg tcatcattga aaaagaacgg gatgttgttt 3651361 ttaattccgg cagcgtcagc tttgtttttg caaagctctc accaatctgg acatttccga 3651421 aattcgcgcc gccgccctta attccgacat ttccgcttgc cgccacaagt gcatcaatcc 3651481 aacgaatcgt tcccccgccg tttttatatc gctgcatgcc aagccccata aaagtagaca 3651541 ccggaccatc agcatacaaa cctgccaaat actccagctc ctccatagaa gtttctgttt 3651601 tcacaataaa ctcttccaga gaaacggtct tcaaaagctc tttcacatca tcaaaaccga 3651661 cagaatgctc agaaataaac gtttcatccg ttcttcccat ctcaatcaga accttcaaaa 3651721 cggctgccgc aagccagccg tccattccag gctttacaga gatatagcgg tcggcaagct 3651781 tagcagtcgg gttgaagatc ggatcaatca ccgtaatcgt ggcgcccttc tttttcacct 3651841 gctgcaagtg atggtataag tgcatatttg ttcttgatac atttcttccc cacacaacaa 3651901 catgcttgct gttgtaaata tcaagcggtc cgtgaccgta cgaacggcca aaatcccagc 3651961 tttgcgcctc gataccggag ccccagcata tgcttccgac gatttcggtc acgccgccat 3652021 atccattaaa aaaacgctga tcaagcgctt ttaacagacc gttattcgca taatcatggc 3652081 tgtgcaaaac agcagtcgtc tccgacgttt ccttgatttc ccgaagttta tcggcaattt 3652141 catcaagtgc ctgctcccaa gaaatccgca caaactcgcc attttgtttt ttcattggat 3652201 agcgaagccg atcaggcgaa tttgtttttg tctcaagcat tctgccgcgg ccgcagattt 3652261 taccttccgt aatcggatgg tttggatctc cgtccacttt tgttaccttt ccatcatcaa 3652321 cagtcaccaa aaagccgcag ctgtcccaac aattcagcgg acatgccgac tgatgcactt 3652381 tgctcatcgc cgtcttctcc ttaccttcta tatgaaaaag catgagtgtc ggcctattta 3652441 tgaagtaggc tcctcatgct tgactagtac tttttttagt tttctttcaa attctcttct 3652501 cggaatcata acactgtgag agcatccctc acacttaatt cgaatatcca ttcccatgcg 3652561 tataattttc cagctgttcg ctccgcatgg atgcggtttt ttcatttcta cgatatcatt 3652621 caggccaaag tctttatccg ccaagaccct tcacctcttt tcctaaactg ctgtatctat 3652681 tgtacaaaaa aactgatcat aagagcaatc aagatacccg aaaagaaata catcctctta 3652741 tttccattta ctcaaaatag gatataagag cagacaaact aacaaataca aattgagcat 3652801 cccatatatc ggatacaaga acgcgatcaa atcagaaaat ccgaaagaag taaaaggtac 3652861 cattaacact aacaaaatca acacaatcat ccatctcggc atatgaataa acgccatcag 3652921 ccggctggac aaacccagca aaccagctac cgtcgtcgtg taaatcgcca ggcacagcac 3652981 cgccgtcata cataaaaaaa ggaaataagg cgcaccctcc agaacggcaa acagcggtat 3653041 ttcaaactga gaaagggagc ccgccagctc caccaacgtt tcattataaa caaatgagat 3653101 cacgccaaaa ataagaccgc ttgccacact tgcgattttt gcttctccga gccctttcat 3653161 ctctttccca acagaggata aaatcgcaac aactgaaagg atgtttaaag aggtaaacgt 3653221 aatgctcgca ggccagttat actgctggga caaatcaatc gtccacgtat ggtgatgtgt 3653281 gctctgaaag gagatcagcg catataaaag ccccgctact aacacaggaa tcaaaatact 3653341 atttatagat aatattcctt tcacatccca caaaaacaag cacactgtca cgatgcaaat 3653401 cagcgtgatt ccccaccaga aaggaagctt gtacatttgc agggtcacac cgcctccggc 3653461 aatcatcacc atagtcgtcg aaaacaaata aaaaatgatg aggacatcat aaattttcgc 3653521 cagccatggc cccattaaat gctccagaac cggcagaaaa tgagtggatt gaaccttaaa 3653581 actgattttc atcacaatat aagacgagaa aatgaacata attgtaaaca gcacaatagc 3653641 aagtccgctt tccgccccaa aaaactgcca tatctcctga ccgctcgcat atccggcccc 3653701 gatcaggctc cctaatatga gcagcatcca cttcattccg gctctccaca acactatcac 3653761 ctcatagaca aagttcagct tgttcccgtt attgttacta tataaataaa ggaaagcaaa 3653821 catgccatat tttcatagac atttgaacac aagctgaaat tatcatacga aatacacata 3653881 aaaaagactg ctaatacggc agtctaaaaa gagatattta tttgtttgtc cgcggaatga 3653941 agaagtgaac ttcactcttc acttttttct aaccattcct acctattcaa gtgtttcata 3654001 agcagaccat tgcttgatca tgatcgaggc aatgggggac aatacttgta atcgcccact 3654061 aaccattcat atcatgccct ctactttttt aaaatctctg gtgccataca caaagcataa 3654121 aaaatcatac tgctggatat actgtaaaca accttacata actacacaca ccatagcaat 3654181 tctgttacct actataacaa ggaagtgaaa cccatgaatc gaaaaggcgg gcttttttct 3654241 tctcaggaac gagtaaagca atatgtttca catacagatg ctgcagcggc aaaacaaatc 3654301 caaaccatcc tttcttcatc cttacgtaaa gctgctggca aaccaattgt cgtggtttgt 3654361 atcggaacag accgttcaac cggtgactca ttaggcccgc tcgtaggaat gaaactcaaa 3654421 cagatgcagc tcaccagatt ccatgtctac ggaaccttat ctgaccccgt ccatgctgtg 3654481 aacatgaagg ataaaatcaa tgacattcat aaattacata aaaacccatt tgttatagca 3654541 gtcgatgcat gcttaggccg cgttaagagt gtgggttcat ttcaaatcgg ggacgggcca 3654601 ttaaagcccg gagccggtgt acaaaaagac cttcctgaag tgggagatct tcatattaac 3654661 ggaatcgtga atgtgagcgg ttttatggaa tattttgtat tgcaaaatac tagactcaac 3654721 ttggtcatga atatggcaaa tgttctagcg gaaggtttga gtttaacaga tcggacagag 3654781 tggaggcaag aacgccttaa cccgttgcaa aggctcactg ggcgcatata aaataaaaac 3654841 catcttcgtt tgaaagatgg ttttttcatt tatgattctc gttcagacaa aagctctaaa 3654901 atccggtcaa ggtcttcatt agagaaaaat tcaatttcga ttttgccttt tttcttctgt 3654961 cttttaatat taactgttgt tccaaaataa ttttggagat aggattcccg ttcttttaga 3655021 accgcatctt tcacaggttc ttttttcttt gtttcacgtg gaacattctg attcaactgc 3655081 tgaatcagct gctcaagttg gcgaacattg agctgctccg caatcacttt ttgtaccagc 3655141 ggttcaagct tatttttgtt ttttaagcca agaagcgtgc gtccatgtcc catagaaagc 3655201 gtgccttcgg caataagctg ttgaatattt tctggcagtg tcagcagtct taaatgattc 3655261 gcaatatgcg gtctgctttt cccaagacgt ttggcaagct gctcttgtgt gagatctaag 3655321 tgtttcaaaa gggagtcata tgcctgagcc tcttcaagcg gagataaatc ttcacgctga 3655381 aggttttcta ataaagcaat ttccctcatt aacgcctctg ataattcacg gacaatggcc 3655441 ggaactgtat ctaaacctgc cagctttgcc gctcgaaaac gccgttcacc cgcaacaata 3655501 tcatagcctt ttaaagattt tctgacgata agcggctgaa gaatgccatg ctgcagcaca 3655561 gattctttta gttcagctaa tgcctcgtca tcaaagtgtt ttcttggctg ataaggatta 3655621 gggcgtaaat cggcaatttt aatttcttca actgtctctt cagacaaatc tacctgatta 3655681 aataacgcat taatcccttt tccaaggcct ttagccattc gcagccactt cctttgctaa 3655741 atctaaatat acttccgcac ctcttgaccg cggatcgtat aaaatgatgg gttttccgtg 3655801 actcggtgcc tcactcagac ggacattacg cggaataact gtcttatata ctttatccct 3655861 aaaatacttt ttaacctctt caatcacttg aatgccaagg tttgtccggg catcaagcat 3655921 tgtcagcaat acaccttcaa tcattaaatc agtattcaaa tgcttttgca caagacgtac 3655981 tgtatttaat aactggctga gaccctccaa ggcataatat tcgcactgta caggaatcac 3656041 aacggaatcc gaggcagtaa gggcattaat cgtcagcaag cccaatgacg gcggacaatc 3656101 aatgataata taatcataat tttgctttac tgcttcaagc gctctcttca atctcacttc 3656161 tcttgatatt gtaggaacca gctcgatctc agcccctgca agctgaatcg tcgcaggaat 3656221 cacatccaag ttctctactg tcgttgcttt aataatatct attacatctg catcatctac 3656281 taaaatatcg tacacacact gctctacatc ggctttttca atccctaatc cgcttgtcgc 3656341 atttccctgc ggatcaatat ctaccagcag aacccttttc cctatgtaag ccaaacatgc 3656401 cccaaggttg acagacgtcg ttgttttgcc gaccccgcct ttttggttcg taattgctat 3656461 gatttttccc acgatgtcac ctactttcac atgaacatgt actatcttgc ttctattcta 3656521 tcaaaaaaag attaaagcgt ttcatttttt tcatcatttt gttccgaatc agaagggaaa 3656581 taattgaaaa ttcaagcacg ctttatgctt tctcttataa attctgcaat ttctatgttt 3656641 ttttgactta aaaaaggaat ttcttaaaga aaaaaagaag aagtcacagt acagaacgtg 3656701 gaaacaggat ggtgagaaaa tggtttatca aacgaagaga gatgtacccg ttacgctgat 3656761 gattgtgttt ctcatattac tgatacaagc agatgccatt gttccttttg tgctgggaaa 3656821 tatgagagtt tccggctgga tcatttttat tctgctgact cttttaaatg gactcatcat 3656881 ttggagcttt attgacctaa aatatgtatt gaaggaacac catctgatca ttaaagccgg 3656941 attgatcaaa catcaaattc cttatgaaaa catcgataaa gtcgttcaaa aaaagaaact 3657001 atggtccggt tttcgtctga tcggctctcg ccatgccatc acaatatatt atcagggggg 3657061 atggggacat gcagtaattt caccgcaaaa atctgaagaa tttatccaca agctcaaaga 3657121 aaagaattct aatataataa tattcactaa aagtaagtga ttaccttttg ttaaaaatat 3657181 aaaaagctct cctgcttttc aggagagctt ctattttggt atgcgaatcg ttaattgaat 3657241 atattcttca aattcttctt cttccgtatt caattttaca ccgctgtctt ccaccattga 3657301 tagtgactgg cgaatcgtgt tcatcgcaat tcttgtatct ctgctgaatg ctttgcgtct 3657361 cggctttggc tttctctggc cttgctccag cattttcacc acgcggtctt ctgtctgctt 3657421 tacatttaaa cttttctcaa taatctctgt gagcagtgtg acttggagct caggctgttt 3657481 cagcggaatc agtgctctgg catggcgctc ggtgattttc ttctccataa tcgcctcttg 3657541 gaccggctga ggcagcttta ataaccgaag cttattcgcg attgtagact gcccttttcc 3657601 taagcgctgt gcgagtgcct cctgtgttaa atcatgcagc tcaagcagcc tagcataagc 3657661 atgcgcttcc tcaatagaag acagttcttc ccgctgcaag ttttcgatta acgccacaga 3657721 agcggtttcc gtgtcggaaa aatccttaat aattgccgga atcttttccc actcaagcga 3657781 ttgcaccgct ctccagcgtc tttcacctgc aatgagttcg tattggcctt cttcttctgt 3657841 atgcctaaca acaatcggct gaataatgcc gtgtgtatga atggtcattg ctaactcttt 3657901 gattttttca tctgagaaaa tggtgcgtgg ctgaaaacgg ttgggaacga tagcatttac 3657961 cggtatttcc agaatctctt ctttgtttgt atcatgttca gcaatctccg gctcctgttc 3658021 cttctcacca agcccgaaga aacgagagaa tgaatgcttc atgtacctac accaccttta 3658081 aaaactgcca tttttataat tctattttct catggttttt cctgctgtac atccatcaat 3658141 tttgatgaaa atatgatggt attgtcatat caggctgtct aaattaccct tcaattggcg 3658201 atttattagg agttcccggt tttcttggat acttcttagg tgtatttttt attttgcgta 3658261 tcaccataat attacgatcg ctttcttcaa taggcagctt aaaagaatgg atattctcaa 3658321 gttctcctcc aagcgtcgtg attgcttttt tgcctgcatt cagttcttct tcagctgatg 3658381 cggcttttaa agcaacaaat aaaccgtttt tcttcaccag aggcaagcaa agctcactca 3658441 aaacagataa tctcgcaact gcgcgcgccg tcacaatatc atagctttca cgcacgtctt 3658501 tccgttgccc gaacgtttca gctctgtcat ggcagaatgt tgtattctcc aattgcaaag 3658561 cttcagacaa cttttctaaa aacgtaatcc gtttgtttag tgaatccacg attgtgacat 3658621 ggaggtgcgg aaagcatatt tttatcggca gacttggaaa acccgctccc gctccaacat 3658681 cacaaatcgt gttcacctga ttgaagtcga cataaaaagc agctgtaatg gaatcataaa 3658741 aatgctttaa atacacttct tttttctctg ttattgaagt cagattgatt ttttcgttcc 3658801 attcaaccag catgtcgtaa tacagctcaa attgctccag ctgacgggga gaaagggaga 3658861 tccctttttc cgccaaacca gaagtgaatt cttcaatatt catgccgtca tcctttctac 3658921 tcggctatct tcgcaatgcg tccctgctct aaatacacca atagaattga aatgtccgcc 3658981 gggtttacac cggaaatgcg ggaagcctgg gcaacagaca aaggccgtac atttttcagt 3659041 ttttgacgcg cctcggtcgc aatcccctta attgcgtcat aatcaattcg gtctggaatt 3659101 tttttatttt ccatcttctt cagtttttcc acttgctgaa gagatttttc aatatatcct 3659161 tcatatttca cttggatttc tacttgttct gccacgtctt gaggaaccgg cacttctggc 3659221 ggcgccagtt ttgtgactgt ttcatagttc atttcaggac gtttcatcaa gtctgtgccg 3659281 cgaactccat ctttcaattc gcttccgcca agagaacgga tatattcttg attttccgga 3659341 gacggcttga taattacaga atgaagacgt tttttctccg cctcgatcgc cgcttttttc 3659401 ttctcaaaag ccgcatagcg ctcatcagaa atcaatccaa tgcgatgtcc gatttctgtc 3659461 agacgcaaat cagcattgtc atggcgaagc agcaatctgt attccgcacg tgatgtcaaa 3659521 agacgatatg gctcattggt accttttgtc acaaggtcat caatcagaac accaatatag 3659581 gcgtcagaac ggcttagaat tacttcttct tttccaagcg cttttcgtcc tgcattgatt 3659641 cccgccataa tcccttgtcc cgcagcttct tcataaccgg atgttccgtt aatttggcct 3659701 gcagtataaa ggtttgtgat ttttttggtt tcaagtgtcg gccatagctg tgtcggtacg 3659761 attgcatcat actcgatcgc atagccggct ctcatcattt gcacgttttc aagtccagga 3659821 atcgttgcaa gcattctttg ctgtacgtct tctggaagac ttgtagataa accttggaca 3659881 tagacttcct gtgtatttct gccttccggc tcaaggaaga tttggtgacg cggtttatca 3659941 ttaaaacgga caactttgtc ttcaatggat gggcagtatc ttgggcccgt acctttgatc 3660001 ataccggaat acatcggtga acggtgcagg ttgctgtcaa taatctcatg tgtctcaggg 3660061 cttgtatatg tcagccagca agggagctga tctgtgatat attccactgt ttcatatgag 3660121 aaagcgcgag gcacatcgtc accaggctga atttccgttt tgctgtaatc aatcgtgtcg 3660181 cttttaacgc gaggcggcgt acctgtttta aaacgaacaa ggtcaaaacc gagttcctcc 3660241 aaatgctcag aaagcttaat agaaggctgc tggttattcg ggccgcttga gtaagacaga 3660301 tcgccaagaa tgatacgtcc tcttaaatat gtccctgtcg tcatgacaac tgctttcgca 3660361 cgataatgtg cgcctgtttg tgtaataacg cctcggcatt cgccgtcttc aacgatcagc 3660421 cgctccacaa ttccttgcag caatgttaag tttggttctt tttcaagcgt atttttcatt 3660481 tcgtgctgat attggaattt gtctgcttgc gcacgcaatg cacgaaccgc aggacctttt 3660541 cctgtattca gcattctcat ttgaatatgt gttttatcga tgtttcttcc catttctccg 3660601 ccgagcgcgt caatttcgcg gacgacaatc ccttttgcgg ggccgccgac agacggatta 3660661 catggcataa atgcaaccat atctaggttg atggtcaaga caagcgtttt ggcgccttgg 3660721 cgtgcagatg cgagggcagc ctcaacaccg gcatgcccgg cgccaatcac aatcacatcg 3660781 tattggcctg cttcataccc catgattcta gttcctcctt taattatttt cctaaacaga 3660841 attgagaaaa gagctgatca attaagcttt cgtggacaga atctccaatg atttccccta 3660901 aaagctccca gcatcttgta aggtcaattt gcaccatgtc gatcgggaca tcctgttcga 3660961 tgccgctaag cgcatcttca atggcgcgtt ttgcttgctg taaaatagtg atgtgacgtg 3661021 tgttgctgac ataagtcaga tcaccgcttt caatggcacc cgtgtagaac agtgattgaa 3661081 tcgcttcttc cagatcattg atgccttcct cttttaaaag agatgtcgta acaactggac 3661141 gtccattggc aagctcacgg acacgttcag tgtcaatctt cggctcaagg tcagtcttat 3661201 tcaaaatcac gataacatcc atgccctcaa cggcttcaaa aagcttcacg tcttcttcag 3661261 aaagctcttc actataatta agcacaagta aaatcaggtc cgcttccttt aggacctggc 3661321 gagaacgttc aacaccgatt cgctcaacaa tatcctctgt ttcacgaata cctgctgtat 3661381 caaccagacg aagcggaacg ccccttacat tcacgtattc ctcaatcaca tcccgtgtcg 3661441 ttccgggaat atcggttaca atggcttttg cctcatgaac gaggctgttc agaagagatg 3661501 attttcctac gtttggccgg ccgataatga cggtagaaag accttcacgc aagatttttc 3661561 cttgctcaga agtcctcagc agcgtctcaa tttccttttt cacggcggtt gccttttcga 3661621 ctaaaatctg atgcgtcatt tcctctacat catcatactc cggataatca atattcacct 3661681 caacatgggc cagtgtttct aaaatctcac tgcgcaaacg gcgcaccaaa gcagaaagac 3661741 gcccttccat ttgattcata gcaacgttca ttgcccggtc cgttttcgct ctgattaagt 3661801 ccataaccgc ttccgcctgt gaaagatcga ttcggccgtt taaaaacgca cgtttcgtaa 3661861 attcaccagg ctctgccagt ctcgctccct ctctcaatgc aagctgaagc acttggttca 3661921 cagtcacaat tcccccgtga cagttaatct cgatgacatc ttctcgtgta aaagttctcg 3661981 gcgcttttaa cactgatacc attacttcct caacgacacg atccgaaggt ctgtctacga 3662041 tatgaccata atgaatcgta tgtgattcga ccgagctgag tgttttcccc ttcggtccct 3662101 tataaatttt atctgcgatt tgaatggctt ctggtccgct caaccgtaca atcgcaatcg 3662161 cgccttctcc catcggtgtg gaaattgccg caattgtatc catgttgttc acctctcttt 3662221 acttatactt catctatata aaaaaatttt tattatgcca aaactaaaag ataacatagt 3662281 ttggttcgaa gtggaagatt tgttatccac agaaatagaa attcgtccct tattacttta 3662341 acttatccac atgtgaataa caattaattt tatttcctga acttcctttt tatcaacagg 3662401 atacacctaa aaagaaaaaa cttaaacggc aaaaccttga tattactagg aaaagtagat 3662461 ttttcggata caaaaaaacc gaaatccaat ttttatcgga cttcggtttt atgctatctt 3662521 ttatgggaaa taacgagatg acgattttcg ccttcaccca ttgaatatgt tttgatctgg 3662581 tggtttgcat atccagaaag agtatcgtga ataatttttc tttcgctgga cggcatgggc 3662641 tcaagctgga tggatttttt cgttttcaaa acctggtcag caagcttgat ggccagctgg 3662701 ctcagtgttt cttttctttt caaacgatag ttttctgcat ccaccgtcac atttttatat 3662761 tggcctggat aacggttaag ggcaagctgt gtcaaagttt caagggcgtt taaagtttgt 3662821 cctcttttcc caatcaacaa tgctgccttt tcacctgtta tatgatatct cactgtcttt 3662881 ttgctttctt gaacagtcac atcagacttc ccggcaatgg cttcggcaat cgtttgaaga 3662941 tataacttcg cttgctgaat cggatcaatc ttttcaacca gctttacgat cgcaggcttt 3663001 ttaccgaaaa taccgagaaa ccctttgttt ccctcttcaa taacagtaat ttctacctta 3663061 tccttcgtta atcccaactc ttgcaatccg gactgtactg cttcatcgac atttcgccct 3663121 gcagcagtca cattcctcac tttttctttc ctccggcttt ttgcggctca ggattttttt 3663181 taatatcagg tcctttaatg aggaaagttt gcgcaatcat aaacaagtta ccaactaccc 3663241 aataaagaga aagagccgcc gggaagttga tcgcaaatac gataatcata attggcataa 3663301 tccaaagcat catcgccatt tgcggatttt gctgcgcatt gccagccatc atcagttttt 3663361 gctgaacaaa tgtagcgaca ccggcaacga taggaagaat atagtaagga tctttttctc 3663421 ctaagtcaaa ccataagaag ctatgctctg aaatcgcctg ggttctcatg atcgcatgat 3663481 agaatccaat taaaatcggc atctggatca aaatcgggaa acatcccgcc aatggattga 3663541 caccatgctt ttggaataaa gccattgttt cctgttgaag cttttgctgc gttttttgat 3663601 cctttgagct gtatttttct ttaagctttt gcatttccgg ctgtaaagcc tgcatcgctt 3663661 tcgaacttct cagctgctta atcatcagcg gtaaaattaa taaacgaatt aaaatggtaa 3663721 ctagaataat tgaaagcccg tagttatctc ccgtcaattt cgctacatac gtaatgagct 3663781 cagacaatgg atatactacg tacttgtccc agaaatgcgg actatctgca gtgatcggct 3663841 ctttcacact cgagcatcca gccaaaagca tgaatacgcc aaccatactt aatagcaacc 3663901 ctattctcct tttcaacaac atttcctcct ataattaatc tttacactct tttattgcaa 3663961 agcatacttg tatgtatttt agcatctttc agttttaaat ggtgtctttt tctgatcaac 3664021 cagaaaggaa gcgcttttaa aagttgtaag aaagcagtgg tgatgcctac tttgacgaag 3664081 atttcttata taatgaagac tttctgaata gatgctgcag actttttttc gtttcctcat 3664141 atgtcagctg gctcgccggt tttctggcaa taatgatgta atccttttcc ttcagtctct 3664201 ctttctcttc aagaaaggcc tgccgaatca aacgtttgat ccgatttcgc atcacagcat 3664261 tgccaatttt tttgctgacg gaaagcccga cacgcagttc atcattttca ggctgatcaa 3664321 gcgtatataa gacaaactgg cggtttgcaa ctgatgtccc atgtttaaac actttttgaa 3664381 aatcttcatt tttctttaaa cgatttcgct tcttcaaatg actcactccg atactggctg 3664441 gcagaaactt ttaaaattta ttatgaacat gagatgcatc tgaaccagga agcatgcccc 3664501 ggttcattac gcatcacatc tatcttttcc cataacgtga aaaaagacca ctgacattat 3664561 tcagtggcct aagctgataa tacttttctg cctttgcggc gacggcgtgc taaaactaga 3664621 cgaccgtttt ttgaactcat acggcttctg aagccatgaa ctttgctgcg tttacggtta 3664681 ttcggttgga atgttctttt catttatgac acctccctcg aggaatagct gttaaagaca 3664741 gtcttactta ttatatttgc gttacctatt cattgtcaac ttcactagtg cttttatttc 3664801 ttgcaaccat aataggatac catacctttt caactttcga aaccttattt tttagattcc 3664861 ttaattttac ggaaaaaaga caaattcaaa caatttgccc ctaaaatcac gcatgtggat 3664921 atctttttcg gcttttttta gtatccacag aggttatcga caacattttc acattaccaa 3664981 cccctgtgga caaggttttt tcaacaggtt gtccgctttg tggataagat tgtgacaacc 3665041 attgcaagct ctcgtttatt ttggtattat atttgtgttt taactcttga ttactaatcc 3665101 tacctttcct ctttatccac aaagtgtgga taagttgtgg attgatttca cacagcttgt 3665161 gtagaaggtt gtccacaagt tgtgaaattt gtcgaaaagc tatttatcta ctatattata 3665221 tgttttcaac atttaatgtg tacgaatggt aagcgccatt tgctcttttt ttgtgttcta 3665281 taacagagaa agacgccatt ttctaagaaa aggagggacg tgccggaag //